PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2532457-4	1989	In many physiologic situations including postural changes, volume expansion, water immersion, high altitude, and lower body negative pressure, the plasma levels of ANP and angiotensin II change inversely.	Water	77-82	angiotensinogen	Homo sapiens	172-186
2697604-2	1989	In recent years the use of a sensitive radioimmunoassay for plasma vasopressin has implicated the role of nonosmotic vasopressin release in the water retention of these edematous disorders.	Water	144-149	arginine vasopressin	Homo sapiens	67-78
2697604-2	1989	In recent years the use of a sensitive radioimmunoassay for plasma vasopressin has implicated the role of nonosmotic vasopressin release in the water retention of these edematous disorders.	Water	144-149	arginine vasopressin	Homo sapiens	117-128
2697604-9	1989	The slower response to restoring EABV involves vasopressin-mediated water retention and aldosterone-mediated sodium retention.	Water	68-73	arginine vasopressin	Homo sapiens	47-58
2697604-10	1989	The renal vasoconstriction which accompanies those states that decrease EABV, by either decreasing cardiac output or causing peripheral arterial vasodilation, limits the distal tubular delivery of sodium and water thus maximizing the water-retaining effect of vasopressin and impairing the normal escape from the sodium-retaining effects of aldosterone.	Water	234-239	arginine vasopressin	Homo sapiens	260-271
2531976-3	1989	To determine the effect of graded exercise on the circulating concentration of the N-terminus and C-terminus of the ANF prohormone in persons with abnormal salt and water metabolism, 12 individuals with stable congestive heart failure (CHF) were evaluated before and after bicycle exercise testing and the results were subdivided based on the maximal exercise they could achieve.	Water	165-170	natriuretic peptide A	Homo sapiens	116-119
2603928-5	1989	The activity of aromatase in microsomal preparations was assayed by determining the rate of incorporation of tritium from 1-[3H]androstenedione into [3H]water.	Water	153-158	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	16-25
2619053-3	1989	Replicate analyses of different bradykinin/glycerol/water mixtures show this improvement to depend upon the glycerol/bradykinin relationship and not the water/bradykinin relationship in sampling 4 nmol of bradykinin from 1% to 56% aqueous glycerol (2 microL initial sample volumes).	Water	52-57	kininogen 1	Homo sapiens	117-127
2619053-3	1989	Replicate analyses of different bradykinin/glycerol/water mixtures show this improvement to depend upon the glycerol/bradykinin relationship and not the water/bradykinin relationship in sampling 4 nmol of bradykinin from 1% to 56% aqueous glycerol (2 microL initial sample volumes).	Water	52-57	kininogen 1	Homo sapiens	117-127
2619053-3	1989	Replicate analyses of different bradykinin/glycerol/water mixtures show this improvement to depend upon the glycerol/bradykinin relationship and not the water/bradykinin relationship in sampling 4 nmol of bradykinin from 1% to 56% aqueous glycerol (2 microL initial sample volumes).	Water	52-57	kininogen 1	Homo sapiens	117-127
2558676-1	1989	These experiments tested whether angiotensin-converting enzyme (ACE) located within the subfornical organ (SFO) participates in the generation of water intake during peripheral ACE blockade with captopril (CAP).	Water	146-151	angiotensin I converting enzyme	Rattus norvegicus	64-67
2605312-1	1989	The molecular dynamics (MD) simulation of superoxide dismutase (SOD) in water is carried out for a total of 23 ps.	Water	72-77	superoxide dismutase 1	Homo sapiens	42-62
2597672-3	1989	PGBx as an oil or as a water-soluble sodium-salt-inhibited Ca2(+)-dependent phospholipase A2 from snake venom, bovine pancreas, human neutrophil and platelet, human synovial fluid, and human sperm with IC50 values ranging from 0.5-7.5 microM.	Water	23-28	phospholipase A2 group IB	Homo sapiens	76-92
2558010-0	1989	Crosslinking of cytochrome c and cytochrome b5 with a water-soluble carbodiimide.	Water	54-59	cytochrome b5 type A	Bos taurus	33-46
2605312-1	1989	The molecular dynamics (MD) simulation of superoxide dismutase (SOD) in water is carried out for a total of 23 ps.	Water	72-77	superoxide dismutase 1	Homo sapiens	64-67
2605312-2	1989	The simulation system is a 26 A sphere centered at the active site of SOD, including 1602 atoms from SOD and 1761 water molecules.	Water	114-119	superoxide dismutase 1	Homo sapiens	70-73
2515241-0	1989	Very high water permeability in vasopressin-induced endocytic vesicles from toad urinary bladder.	Water	10-15	arginine vasopressin	Homo sapiens	32-43
2558010-2	1989	A water soluble carbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), has been used to crosslink horse heart cytochrome c and trypsin-solubilized bovine liver microsomal cytochrome b5.	Water	2-7	cytochrome b5 type A	Bos taurus	183-196
2515241-9	1989	The rapid fluorescence decrease was absent in vesicles in groups B, C, and D. These results demonstrate the presence of functional water transporters in vasopressin-induced endocytic vesicles from toad bladder, supporting the hypothesis that water channels are cycled to and from the luminal membrane and providing a functional marker for the vasopressin-sensitive water channel.	Water	131-136	arginine vasopressin	Homo sapiens	153-164
2515241-9	1989	The rapid fluorescence decrease was absent in vesicles in groups B, C, and D. These results demonstrate the presence of functional water transporters in vasopressin-induced endocytic vesicles from toad bladder, supporting the hypothesis that water channels are cycled to and from the luminal membrane and providing a functional marker for the vasopressin-sensitive water channel.	Water	131-136	arginine vasopressin	Homo sapiens	343-354
2531013-2	1989	Previous reports suggested an inhibitory effect of ANF on some of the central actions of ANG II, such as water intake and vasopressin release.	Water	105-110	angiotensinogen	Rattus norvegicus	89-95
16667199-13	1989	Pectinmethylesterase is not needed for jelly fig seed germination, however the gel formed from pectin and pectinmethylesterase may insure a water source for the germinating jelly fig seeds.	Water	140-145	pectinesterase/pectinesterase inhibitor U1	Solanum lycopersicum	106-126
2632718-1	1989	The role of vasopressin in the regulation of body water volume and its distribution to intravascular, interstitial and intracellular compartments, and the importance of particular body water compartments in the pathogenesis of DOCA-salt hypertension were studied in young Brattleboro rats.	Water	50-55	arginine vasopressin	Rattus norvegicus	12-23
2632718-4	1989	The development of DOCA-salt hypertension was attenuated in the vasopressin-deficient rats, which had a similar level of total body water, slightly increased intracellular water and significantly decreased extracellular fluid volume compared with the hypertensive vasopressin-synthesizing rats.	Water	132-137	arginine vasopressin	Rattus norvegicus	64-75
2632718-4	1989	The development of DOCA-salt hypertension was attenuated in the vasopressin-deficient rats, which had a similar level of total body water, slightly increased intracellular water and significantly decreased extracellular fluid volume compared with the hypertensive vasopressin-synthesizing rats.	Water	172-177	arginine vasopressin	Rattus norvegicus	64-75
2632718-5	1989	Consequently, in the vasopressin-deficient rats, the ratio of extracellular fluid volume to intracellular water did not differ from that of controls.	Water	106-111	arginine vasopressin	Rattus norvegicus	21-32
2532366-1	1989	The role of peptides from the N terminus and C terminus of the 126 amino acid atrial natriuretic factor (ANF) prohormone in modulating renal sodium and water handling has not been defined.	Water	152-157	natriuretic peptide A	Homo sapiens	78-103
2532366-1	1989	The role of peptides from the N terminus and C terminus of the 126 amino acid atrial natriuretic factor (ANF) prohormone in modulating renal sodium and water handling has not been defined.	Water	152-157	natriuretic peptide A	Homo sapiens	105-108
2583289-1	1989	The water soluble carbodiimide N-cyclohexyl-N"-2-morpholinoethyl-carbodiimide-methyl-p-toluolsulfona te was found to effectively covalently cross-link pancreatic colipase to lipase as evidenced by Western blotting experiments using antibodies directed either against lipase or colipase.	Water	4-9	pancreatic lipase	Equus caballus	164-170
2583289-1	1989	The water soluble carbodiimide N-cyclohexyl-N"-2-morpholinoethyl-carbodiimide-methyl-p-toluolsulfona te was found to effectively covalently cross-link pancreatic colipase to lipase as evidenced by Western blotting experiments using antibodies directed either against lipase or colipase.	Water	4-9	pancreatic lipase	Equus caballus	174-180
2629536-0	1989	[Dynamics of the level of plasma vasopressin and its role in the regulation of water-electrolyte metabolism in patients following aortocoronary bypass].	Water	79-84	arginine vasopressin	Homo sapiens	33-44
2688434-10	1989	Vasopressin binding to receptors located at the basal membrane of principal cells initiates adenosine 3",5"-cyclic monophosphate production, which is thought ultimately to activate the exocytic insertion of intracellular vesicles containing water channels into the cell apical membrane.	Water	241-246	arginine vasopressin	Homo sapiens	0-11
2582988-0	1989	Effect of bradykinin on feline gallbladder water transport and prostanoid formation.	Water	43-48	kininogen 1	Homo sapiens	10-20
2584679-4	1989	Investigation revealed fungal contamination of two brushes used to clean the bronchoscope channels and one positive sample of the tub water used to test the integrity of the bronchoscope prior to cleaning and disinfection.	Water	134-139	TUB bipartite transcription factor	Homo sapiens	130-133
2689836-16	1989	Calcium chloride infusion, dextrose and insulin in water, and correction of acidosis with sodium bicarbonate are helpful in controlling the acute, life-threatening cardiac arrhythmias.	Water	51-56	insulin	Homo sapiens	40-47
2792662-0	1989	Blockade of the hydroosmotic effect of vasopressin normalizes water excretion in cirrhotic rats.	Water	62-67	arginine vasopressin	Rattus norvegicus	39-50
2792662-5	1989	Treatment with the vasopressin antagonist normalized water excretion in 9 of the 10 rats.	Water	53-58	arginine vasopressin	Rattus norvegicus	19-30
2792662-7	1989	These results indicate that vasopressin hypersecretion is the predominant mechanism of the impairment in water excretion in rats with experimental cirrhosis and ascites.	Water	105-110	arginine vasopressin	Rattus norvegicus	28-39
2700000-6	1989	In rats with 5/6 nephrectomy, we increased experimentally water intake in order to decrease circulating VP levels, urine concentration, and free water reabsorption.	Water	58-63	arginine vasopressin	Rattus norvegicus	104-106
2797079-5	1989	To determine the natural history of diabetes insipidus in children with histiocytosis, we measured the response of urinary arginine vasopressin to water deprivation every six months in 21 children who did not have diabetes insipidus and who had had histiocytosis for less than four years.	Water	147-152	arginine vasopressin	Homo sapiens	132-143
2818589-3	1989	Treatment of these cells with interleukin 3 rapidly stimulated both the release of water-soluble choline metabolites and the resynthesis of phosphatidylcholine.	Water	83-88	interleukin 3	Mus musculus	30-43
2575159-1	1989	Norethisterone and ethinyloestradiol concentrations in sewage effluent, reservoirs, rivers and potable water have been estimated at less than 20 ng L-1, a value unlikely to present a significant risk to human health.	Water	103-108	immunoglobulin kappa variable 1-16	Homo sapiens	148-151
2590842-5	1989	The test dose of Ang II, 50 ng/kg/min IV for 1 hr, increased water intake and arterial pressure.	Water	61-66	angiotensinogen	Rattus norvegicus	17-23
2557291-1	1989	investigation of the hydrogen exchange in H2O of the peptide fragment B23-B29 of insulin.	Water	42-45	insulin	Homo sapiens	81-88
2557291-2	1989	Detailed and precise information on the exchanges in water of the peptide hydrogens of the insulin fragment B23-B29 (Gly23-Phe24-Phe25-Tyr26-Thr27-Pro28 -Lys29) has been obtained from magnetization-transfer measurements, and nonlinear least-squares fits of the experimental spectra using the expression for the discrete Fourier transform of a sum of exponentially damped sinusoids.	Water	53-58	insulin	Homo sapiens	91-98
2610860-2	1989	It is shown by a surface-thermodynamic approach that, upon dehydration by ethanol, isoelectric serum albumin molecules as well as isoelectric serum gamma globulin molecules will attract each other to a sufficient degree by van der Waals forces to become insoluble in the ethanol-water mixtures used.	Water	279-284	albumin	Homo sapiens	95-108
2812759-8	1989	Our data show that for the postoperative water retention first of all the increased AVP activity is responsible.	Water	41-46	arginine vasopressin	Homo sapiens	84-87
2600595-3	1989	Both hydrogen peroxide and water formation lower the efficiency of the monooxygenatic activity of cytochrome P-450.	Water	27-32	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-114
2588725-2	1989	Pathophysiologically, the two forms underlie an activation of the renin-angiotensin-aldosterone system with subsequent retention of water and common salt.	Water	132-137	renin	Homo sapiens	66-71
2622326-0	1989	Pathogenesis of Treponema hyodysenteriae: induction of interleukin-1 and tumor necrosis factor by a treponemal butanol/water extract (endotoxin).	Water	119-124	tumor necrosis factor	Mus musculus	73-94
2642114-4	1989	Volume expansion with water corrected hypernatremia (162 to 148 mEq/l) and resulted in an increased urine flow and urinary dilution (137 mosmol/kg) because of suppression of endogenous vasopressin (AVP) release (5.1 pg/ml).	Water	22-27	arginine vasopressin	Homo sapiens	185-196
2642114-4	1989	Volume expansion with water corrected hypernatremia (162 to 148 mEq/l) and resulted in an increased urine flow and urinary dilution (137 mosmol/kg) because of suppression of endogenous vasopressin (AVP) release (5.1 pg/ml).	Water	22-27	arginine vasopressin	Homo sapiens	198-201
2792382-0	1989	Inactivation of human thrombin by water-soluble carbodiimides.	Water	34-39	coagulation factor II, thrombin	Homo sapiens	22-30
2797788-2	1989	The stimulability of residual vasopressin was confirmed by water deprival and the partial vasopressin deficit by the administration of dDAVP.	Water	59-64	arginine vasopressin	Homo sapiens	30-41
2797788-3	1989	Water loading test referred to the possibility of suppression of residual vasopressin.	Water	0-5	arginine vasopressin	Homo sapiens	74-85
2611291-1	1989	Study of temperature dependence of heat capacity in denatured biopolymers (collagen, elastin, lysozyme, DNA) with 10-15% of bound water revealed a characteristic jump at some critical temperature Tc.	Water	130-135	lysozyme	Homo sapiens	94-102
2760376-3	1989	The neuropeptide that is responsible for water homeostasis and defense against dehydration, vasopressin, is also under direct cholinergic control.	Water	41-46	arginine vasopressin	Homo sapiens	92-103
2591876-5	1989	Mechanism of carpal tunnel syndrome in acromegaly is that edematous synovial tissues compress the median nerve because oversecretion of growth hormone causes increase of sodium and water retention in the extracellular fluid.	Water	181-186	growth hormone 1	Homo sapiens	136-150
2626449-5	1989	This effect was not due to a lesion-induced change in the pharmacokinetics of alcohol and was observed only in those animals whose lesions produced a functional deficit, i.e., abolishing the increase in water drinking produced by ANG II.	Water	203-208	angiotensinogen	Homo sapiens	230-236
2626449-1	1989	The subfornical organ plays a role in a number of the effects of blood-borne angiotensin II (ANG II) including the increase in water drinking and blood pressure and the release of vasopressin from the pituitary.	Water	127-132	angiotensinogen	Homo sapiens	77-91
2626449-1	1989	The subfornical organ plays a role in a number of the effects of blood-borne angiotensin II (ANG II) including the increase in water drinking and blood pressure and the release of vasopressin from the pituitary.	Water	127-132	angiotensinogen	Homo sapiens	93-99
2550621-5	1989	After 4 hr incubation in vitro, dioctylphthalate and benzylbutylphthalate significantly inhibited vasopressin-stimulated water flow in toad bladder.	Water	121-126	arginine vasopressin	Homo sapiens	98-109
2607664-1	1989	The mucosal superoxide dismutase (SOD) activities were serially examined on the acute gastric mucosal lesion (AGML) induced by water-immersion restraint stress to rats for six hours.	Water	127-132	superoxide dismutase 1	Homo sapiens	12-32
2607664-1	1989	The mucosal superoxide dismutase (SOD) activities were serially examined on the acute gastric mucosal lesion (AGML) induced by water-immersion restraint stress to rats for six hours.	Water	127-132	superoxide dismutase 1	Homo sapiens	34-37
2764161-1	1989	We compared the effects of neuropeptide Y (NPY) injected into the lateral ventricle (LV) and periphery (ip in rats; iv in sheep) on feed and water intake.	Water	141-146	neuropeptide Y	Rattus norvegicus	27-41
2765911-7	1989	NPY also significantly inhibited the intake of water flavored with 8% sucrose and 0.1% quinine.	Water	47-52	neuropeptide Y	Rattus norvegicus	0-3
2669525-5	1989	Because AVP release is not suppressed at the usual levels of tonicity, it still circulates and water is retained.	Water	95-100	arginine vasopressin	Homo sapiens	8-11
2669525-7	1989	The metabolic clearance rate of AVP is also altered, increasing three- to fourfold between gestational week 10 and midtrimester, paralleling the appearance and rapid rise in circulating cystine-aminopeptidase (vasopressinase), an observation that may explain several disorders of water handling that complicate human pregnancy.	Water	280-285	arginine vasopressin	Homo sapiens	32-35
2669525-7	1989	The metabolic clearance rate of AVP is also altered, increasing three- to fourfold between gestational week 10 and midtrimester, paralleling the appearance and rapid rise in circulating cystine-aminopeptidase (vasopressinase), an observation that may explain several disorders of water handling that complicate human pregnancy.	Water	280-285	leucyl and cystinyl aminopeptidase	Homo sapiens	210-224
2764161-7	1989	Water intake was stimulated (P less than 0.05) by NPY (LV injection) in both the presence and absence of feed.	Water	0-5	pro-neuropeptide Y	Ovis aries	50-53
2698139-6	1989	As known for several decades, concentrating function is primarily regulated by the effect of antidiuretic hormone (ADH) on water permeability of the collecting duct.	Water	123-128	arginine vasopressin	Homo sapiens	93-113
2698139-6	1989	As known for several decades, concentrating function is primarily regulated by the effect of antidiuretic hormone (ADH) on water permeability of the collecting duct.	Water	123-128	arginine vasopressin	Homo sapiens	115-118
2698142-1	1989	Plasma osmolality is maintained within very narrow limits by the control of water intake via thirst and water output via secretion of vasopressin.	Water	76-81	arginine vasopressin	Homo sapiens	134-145
2698142-1	1989	Plasma osmolality is maintained within very narrow limits by the control of water intake via thirst and water output via secretion of vasopressin.	Water	104-109	arginine vasopressin	Homo sapiens	134-145
2698142-5	1989	Both raised plasma osmolality and reduced blood volume contribute to thirst and vasopressin secretion following water deprivation.	Water	112-117	arginine vasopressin	Homo sapiens	80-91
2698145-3	1989	Indirect methods of investigating polyuria are inaccurate in a significant proportion of cases, and the incorporation of measurements of plasma AVP into a water-deprivation test or hypertonic saline infusion can improve diagnostic accuracy.	Water	155-160	arginine vasopressin	Homo sapiens	144-147
2776691-2	1989	The administration of lead (100 ppm in drinking water) inhibited the activity of blood delta-aminolevulinic acid dehydratase; decreased hemoglobin, brain dopamine, and 5-hydroxytryptamine; and increased urinary excretion of delta-aminolevulinic acid, blood zinc protoporphyrin, and tissue accumulation of lead more markedly in animals fed a protein-deficient diet (10% casein) than in those fed a normal diet (21% casein).	Water	48-53	aminolevulinate dehydratase	Rattus norvegicus	87-124
2546748-4	1989	Naloxone (0.5 mg/kg) significantly enhanced AVP secretion after 72-h water deprivation.	Water	69-74	arginine vasopressin	Rattus norvegicus	44-47
2795641-1	1989	Water transport across the mammalian collecting tubule is regulated by vasopressin-dependent water channel insertion into and retrieval from the cell apical membrane.	Water	0-5	arginine vasopressin	Homo sapiens	71-82
2503030-0	1989	The surface properties of apolipoproteins A-I and A-II at the lipid/water interface.	Water	68-73	apolipoprotein A1	Homo sapiens	26-54
2503030-1	1989	The monolayer system was employed to investigate the relative affinities of apolipoproteins A-I and A-II for the lipid/water interface.	Water	119-124	apolipoprotein A1	Homo sapiens	76-104
2503030-4	1989	Comparison of the molecular packing of apolipoproteins A-I and A-II suggests that apoA-II adopts a more condensed conformation at the lipid/water interface compared to apoA-I.	Water	140-145	apolipoprotein A1	Homo sapiens	82-88
2509777-1	1989	Staphylococcal enterotoxin A (SEA), a T cell mitogen, was found to induce a high level of interferon-gamma (IFN-gamma) in mice which had been immunized with killed Bacillus Calmette-Guerin (BCG) in water-in-oil-in-water (W/O/W) emulsion.	Water	198-203	interferon gamma	Mus musculus	90-106
2795641-1	1989	Water transport across the mammalian collecting tubule is regulated by vasopressin-dependent water channel insertion into and retrieval from the cell apical membrane.	Water	93-98	arginine vasopressin	Homo sapiens	71-82
2509777-1	1989	Staphylococcal enterotoxin A (SEA), a T cell mitogen, was found to induce a high level of interferon-gamma (IFN-gamma) in mice which had been immunized with killed Bacillus Calmette-Guerin (BCG) in water-in-oil-in-water (W/O/W) emulsion.	Water	198-203	interferon gamma	Mus musculus	108-117
2509777-1	1989	Staphylococcal enterotoxin A (SEA), a T cell mitogen, was found to induce a high level of interferon-gamma (IFN-gamma) in mice which had been immunized with killed Bacillus Calmette-Guerin (BCG) in water-in-oil-in-water (W/O/W) emulsion.	Water	214-219	interferon gamma	Mus musculus	90-106
2787395-0	1989	The effect of intravenous interleukin-2 on brain water content.	Water	49-54	interleukin 2	Homo sapiens	26-39
2509777-1	1989	Staphylococcal enterotoxin A (SEA), a T cell mitogen, was found to induce a high level of interferon-gamma (IFN-gamma) in mice which had been immunized with killed Bacillus Calmette-Guerin (BCG) in water-in-oil-in-water (W/O/W) emulsion.	Water	214-219	interferon gamma	Mus musculus	108-117
2803915-1	1989	Administration of either tumour necrosis factor alpha (TNF-alpha) or 16,16-dimethylprostaglandin E2 (PGE2) to female NMRI mice caused a decrease in body weight accompanied by a reduction in both food and water intake and a decrease in carcass water content.	Water	204-209	tumor necrosis factor	Mus musculus	55-64
2485613-1	1989	Angiotensin II (1 microgram) dissolved in water and given intracerebroventricularly on day 1, 15 min before the first learning session, enhanced rate of learning of active avoidance in rats over the next 7 days.	Water	42-47	angiotensinogen	Rattus norvegicus	0-14
2787395-14	1989	In patients with extracranial cancer but no brain disease, parenteral IL-2 induces an increase in the cerebral water content of both gray and white matter.	Water	111-116	interleukin 2	Homo sapiens	70-74
2546806-4	1989	Two-dimensional NMR spectra were used to examine the conformational behavior in methanol and in water solution of two fragments of adrenocorticotropin, ACTH(1-24) and ACTH (1-13), as well as their antisense peptides, HTCA and HTCA(12-24).	Water	96-101	proopiomelanocortin	Homo sapiens	152-156
2546806-4	1989	Two-dimensional NMR spectra were used to examine the conformational behavior in methanol and in water solution of two fragments of adrenocorticotropin, ACTH(1-24) and ACTH (1-13), as well as their antisense peptides, HTCA and HTCA(12-24).	Water	96-101	proopiomelanocortin	Homo sapiens	167-171
2753032-6	1989	We suggest that the N-terminal tetrapeptide, in particular lysine-4, is essential for the binding of human gastric lipase to lipid/water interfaces, and hence, for its physiological function.	Water	131-136	lipase F, gastric type	Homo sapiens	107-121
2731160-1	1989	When injected into female NMRI mice tumour necrosis factor-alpha (TNF) produced a dose-related weight loss over the first 24 h, which was accompanied by and directly proportional to a decrease in both food and water intake.	Water	210-215	tumor necrosis factor	Mus musculus	66-69
2767407-0	1989	Prolactin cell activity and sodium fluxes in tilapia (Oreochromis mossambicus) after long-term acclimation to acid water.	Water	115-120	prolactin	Sus scrofa	0-9
2767407-1	1989	In tilapia exposed for 3 months to water of pH 4.5, prolactin cell activity, as estimated by ultrastructural morphometry and determination of prolactin synthesis in vitro, was significantly higher than in controls from neutral water.	Water	35-40	prolactin	Sus scrofa	52-61
2767407-1	1989	In tilapia exposed for 3 months to water of pH 4.5, prolactin cell activity, as estimated by ultrastructural morphometry and determination of prolactin synthesis in vitro, was significantly higher than in controls from neutral water.	Water	35-40	prolactin	Sus scrofa	142-151
2767407-1	1989	In tilapia exposed for 3 months to water of pH 4.5, prolactin cell activity, as estimated by ultrastructural morphometry and determination of prolactin synthesis in vitro, was significantly higher than in controls from neutral water.	Water	227-232	prolactin	Sus scrofa	52-61
2767407-4	1989	It is concluded that tilapia are able to acclimate to acid water by successful control--probably via prolactin--of diffusional sodium losses across the integument, in particular the gill surface.	Water	59-64	prolactin	Sus scrofa	101-110
2794798-1	1989	The "esterase" activity of hormone-sensitive lipase (HSL) was studied using water-soluble p-nitrophenyl butyrate (PNPB) as a substrate.	Water	76-81	lipase E, hormone sensitive type	Bos taurus	27-51
2794798-1	1989	The "esterase" activity of hormone-sensitive lipase (HSL) was studied using water-soluble p-nitrophenyl butyrate (PNPB) as a substrate.	Water	76-81	lipase E, hormone sensitive type	Bos taurus	53-56
2799756-4	1989	These data suggest that the PMN CL response requires the HOCl production by the following pathway: H2O2 + Cl--MPO----H+ HOCl + H2O.	Water	99-102	myeloperoxidase	Homo sapiens	110-113
2813560-6	1989	The results showed that the intrarenal infusion of NPY at 1 microgram/kg/min increased sodium and water excretion relative to the saline control group without altering blood pressure or creatinine clearance.	Water	98-103	neuropeptide Y	Rattus norvegicus	51-54
2813560-7	1989	Similarly, ICV administration of NPY at 10 micrograms in a 5 microliters volume increased the excretion of sodium and water without altering blood pressure as compared to the artificial CSF group.	Water	118-123	neuropeptide Y	Rattus norvegicus	33-36
2813560-8	1989	These findings suggest that both central and peripheral NPY may contribute to the regulation of sodium and water excretion in the rat.	Water	107-112	neuropeptide Y	Rattus norvegicus	56-59
2731160-4	1989	Weight loss induced by TNF was reversed by both glucose and MCT and by administration of the equivalent volumes of water alone.	Water	115-120	tumor necrosis factor	Mus musculus	23-26
2736884-12	1989	ANG II also reduced fractional distal delivery [(sodium clearance plus free water clearance) divided by creatinine clearance], another measure of proximal tubular outflow.	Water	76-81	angiotensinogen	Homo sapiens	0-6
2499676-3	1989	The present study was designed to examine the effects of serosal DMSO at three osmolar concentrations on Basal Water Flow and vasopressin (AVP)- and cyclic AMP-stimulated water flow (Maximal Water Flow) in the toad bladder.	Water	171-176	arginine vasopressin	Homo sapiens	126-137
2598831-4	1989	Dietary addition of a recombination of hexane, ethanol and ethanol-water extracts caused a toxicity response (depressed feed intake, ADG, and serum Prl) equivalent to that of the whole seed.	Water	67-72	prolactin	Rattus norvegicus	148-151
2553424-1	1989	Atrial natriuretic peptide (ANP) increases renal sodium and water excretion in several species including man.	Water	60-65	natriuretic peptide A	Homo sapiens	0-26
2553424-1	1989	Atrial natriuretic peptide (ANP) increases renal sodium and water excretion in several species including man.	Water	60-65	natriuretic peptide A	Homo sapiens	28-31
2545411-18	1989	Cholinergic agonists and VIP also stimulate lacrimal gland fluid secretion, and the same signal transduction pathways utilized by these agonists to stimulate protein secretion are most likely used for electrolyte and water secretion.	Water	217-222	vasoactive intestinal peptide	Homo sapiens	25-28
2499676-7	1989	At 300 mOsm final concentration, all three agents increased AVP-stimulated water flow.	Water	75-80	arginine vasopressin	Homo sapiens	60-63
2499676-10	1989	In the presence of verapamil, AVP-stimulated water flow was decreased markedly; when DMSO was added to verapamil-pretreated hemibladders, and they were then challenged with AVP, water flow increased significantly.	Water	45-50	arginine vasopressin	Homo sapiens	30-33
2755369-0	1989	Vasopressin inhibition via combined head-out water immersion and a prostaglandin E-1 precursor in the treatment of male reproductive failure due to chronic alcohol abuse.	Water	45-50	arginine vasopressin	Homo sapiens	0-11
2499676-10	1989	In the presence of verapamil, AVP-stimulated water flow was decreased markedly; when DMSO was added to verapamil-pretreated hemibladders, and they were then challenged with AVP, water flow increased significantly.	Water	178-183	arginine vasopressin	Homo sapiens	30-33
2755369-3	1989	Since head-out water immersion rapidly decreases vasopressin levels, a suggested joint protocol of head-out water immersion and a prostaglandin E-1 precursor is proposed for male reproductive failure in alcoholics.	Water	15-20	arginine vasopressin	Homo sapiens	49-60
2781306-2	1989	The results suggest that BNP may be a novel neurotransmitter or circulatory hormone, which is widely distributed in various tissues and involved in the regulation of water electrolyte balance and cardiovascular activity.	Water	166-171	natriuretic peptide B	Rattus norvegicus	25-28
2770750-10	1989	wt protein may be an important step in VIP regulation of water and electrolyte secretion from colonic epithelial cells, and in VIP regulation of immunoglobulin and lymphokine secretion from lymphocytes.	Water	57-62	vasoactive intestinal peptide	Homo sapiens	39-42
2671776-8	1989	Similarly, in the oral water-loaded group serum DLF increased from 49 +/- 15 at time 0 to 127 +/- 24 pg digoxin Eq/ml at peak (p less than 0.01) after they received insulin.2=	Water	23-28	insulin	Homo sapiens	165-172
2505349-0	1989	Effect of insulin administration on water drinking in children.	Water	36-41	insulin	Homo sapiens	10-17
2505349-1	1989	The effect of insulin administration on water intake, was studied in children submitted to standard protocols for stimulation of secretion of hypophyseal hormones by i.v.	Water	40-45	insulin	Homo sapiens	14-21
2505349-4	1989	Water intake was significantly higher in both groups of patients receiving insulin than in the control group (no insulin).	Water	0-5	insulin	Homo sapiens	75-82
2505349-4	1989	Water intake was significantly higher in both groups of patients receiving insulin than in the control group (no insulin).	Water	0-5	insulin	Homo sapiens	113-120
2470262-2	1989	We examined the effect of two such agents on vasopressin-induced water transport across toad urinary bladder.	Water	65-70	arginine vasopressin	Homo sapiens	45-56
2469472-14	1989	The inhibitory effect at high albumin concentrations is probably the result of removal of free fatty acids from the micelle: fatty acids are known to cause stimulation of phospholipase A2 by providing a negative charge to the lipid/water interface.	Water	232-237	phospholipase A2 group IB	Homo sapiens	171-187
2736078-3	1989	In the water-sated condition, the group exposed to alcohol prenatally had plasma levels of AVP seven-fold above control levels.	Water	7-12	arginine vasopressin	Rattus norvegicus	91-94
2736078-7	1989	In the control animals, 24-hr of water deprivation produced the expected increase in AVP, in plasma and urine osmolality, and decrease in urine production.	Water	33-38	arginine vasopressin	Rattus norvegicus	85-88
2470262-10	1989	Our results parallel closely those reported by other investigators for water flow across erythrocytes and proximal renal tubule and suggest that mercurial reagents can directly block the vasopressin-induced water channel.	Water	71-76	arginine vasopressin	Homo sapiens	187-198
2470262-10	1989	Our results parallel closely those reported by other investigators for water flow across erythrocytes and proximal renal tubule and suggest that mercurial reagents can directly block the vasopressin-induced water channel.	Water	207-212	arginine vasopressin	Homo sapiens	187-198
2736199-4	1989	The stimulation of tumour growth by insulin was counteracted by the inclusion of 3-hydroxybutyrate in the drinking water without any alteration in the extent of weight loss.	Water	115-120	insulin	Homo sapiens	36-43
2483649-6	1989	The fog water droplets coalesce around preexisting aerosol which is most highly concentrated near the ground (cities and industrial areas).	Water	8-13	zinc finger protein, FOG family member 1	Homo sapiens	4-7
2483649-7	1989	Since fog water droplets contain muc less water than rain drops, they do not dilute the acidity as much as rain.	Water	10-15	zinc finger protein, FOG family member 1	Homo sapiens	6-9
2483649-7	1989	Since fog water droplets contain muc less water than rain drops, they do not dilute the acidity as much as rain.	Water	42-47	zinc finger protein, FOG family member 1	Homo sapiens	6-9
2765584-1	1989	Scanning calorimetry has been used for studying lysozyme water solutions of different buffer molarity (mu = 0.5 divided by 1.0) and concentrations (c = 1.5 divided by 25%) at pH 2.0.	Water	57-62	lysozyme	Homo sapiens	48-56
2525441-0	1989	Water immersion-induced alterations of plasma atrial natriuretic peptide level and its relationship to the renin-angiotensin-aldosterone system and vasopressin secretion in acute and chronic renal failure.	Water	0-5	renin	Homo sapiens	107-112
2525441-0	1989	Water immersion-induced alterations of plasma atrial natriuretic peptide level and its relationship to the renin-angiotensin-aldosterone system and vasopressin secretion in acute and chronic renal failure.	Water	0-5	arginine vasopressin	Homo sapiens	148-159
2525441-1	1989	Water immersion (WI)-induced alterations of circulating plasma volume (PV), plasma renin activity (PRA), plasma levels of aldosterone (Ald), vasopressin (AVP) and atrial natriuretic peptide (ANP) were examined in 12 patients with noninflammatory acute renal failure (ARF) at the anuric/oliguric phase, in 20 hemodialyzed patients with chronic renal failure and in 15 healthy subjects.	Water	0-5	renin	Homo sapiens	83-88
2525441-1	1989	Water immersion (WI)-induced alterations of circulating plasma volume (PV), plasma renin activity (PRA), plasma levels of aldosterone (Ald), vasopressin (AVP) and atrial natriuretic peptide (ANP) were examined in 12 patients with noninflammatory acute renal failure (ARF) at the anuric/oliguric phase, in 20 hemodialyzed patients with chronic renal failure and in 15 healthy subjects.	Water	0-5	arginine vasopressin	Homo sapiens	141-152
2717286-7	1989	Urine osmolality greater than 800 mosm/kg was associated with markedly increased urine vasopressin levels (200 to 1,650 pg/mL); children with this finding may be at particular risk for the syndrome of inappropriate secretion of anti-diuretic hormone without restrictive water intake.	Water	270-275	arginine vasopressin	Homo sapiens	87-98
2725842-2	1989	Two days of water deprivation resulted in significant increases in hematocrit, plasma osmolality and vasopressin levels, indicating a functional activation of magnocellular vasopressin neurons.	Water	12-17	arginine vasopressin	Rattus norvegicus	101-112
2548897-1	1989	An increase in the water permeability of the frog urinary bladder due to vasopressin, correlates with an increase of cAMP content in the bladder tissue.	Water	19-24	arginine vasopressin	Homo sapiens	73-84
2548897-4	1989	The augmentation of cAMP content seems to lead to a rise in water permeability white inositol triphosphate and cGMP acted, probably, as modulators of the vasopressin effect.	Water	60-65	arginine vasopressin	Homo sapiens	154-165
2523413-2	1989	Within the heart, a recently discovered hormone, atrial natriuretic factor (ANF), has been implicated in the maintenance of water and salt balance.	Water	124-129	natriuretic peptide A	Homo sapiens	49-74
2523413-2	1989	Within the heart, a recently discovered hormone, atrial natriuretic factor (ANF), has been implicated in the maintenance of water and salt balance.	Water	124-129	natriuretic peptide A	Homo sapiens	76-79
2725842-2	1989	Two days of water deprivation resulted in significant increases in hematocrit, plasma osmolality and vasopressin levels, indicating a functional activation of magnocellular vasopressin neurons.	Water	12-17	arginine vasopressin	Rattus norvegicus	173-184
2528228-1	1989	Simultaneous studies were performed on changes in water permeability and on the ultrastructural organization of the frog urinary bladder epithelium in the presence of Co-ions under vasopressin-stimulated water flow.	Water	204-209	arginine vasopressin	Homo sapiens	181-192
2780875-1	1989	Intracranial injections of prolactin (PRL) have been previously shown to elevate food and water intake in ring doves.	Water	90-95	prolactin	Homo sapiens	27-36
2780875-1	1989	Intracranial injections of prolactin (PRL) have been previously shown to elevate food and water intake in ring doves.	Water	90-95	prolactin	Homo sapiens	38-41
2780875-3	1989	PRL increased food consumption by 35-50% over baseline levels in water deprived and nondeprived doves, although response latencies (10 hr) and durations (greater than 24 hr) were considerably longer than those reported for other orexigenic peptides.	Water	65-70	prolactin	Homo sapiens	0-3
2780875-5	1989	In contrast to this pattern, water intake remained unchanged in food deprived doves and was only marginally increased in nondeprived doves following PRL treatment.	Water	29-34	prolactin	Homo sapiens	149-152
2788883-2	1989	Our results show that pigmented tissue is lacking in manganese superoxide dismutase activity and that the main enzymatic activity utilized in the cytosol by pigmented cells to reduce the hydrogen peroxide to water is represented by catalase; on the contrary, for the same reaction, the cells of albino rat liver primarily utilize the glutathione peroxidase activity.	Water	208-213	catalase	Rattus norvegicus	232-240
2528228-2	1989	A possible inhibition of the vasopressin-stimulated water flows by Co-ions is supposed from the extracellular surface of the apical membrane of granular cells responsible for water permeability of this epithelium.	Water	52-57	arginine vasopressin	Homo sapiens	29-40
2528228-2	1989	A possible inhibition of the vasopressin-stimulated water flows by Co-ions is supposed from the extracellular surface of the apical membrane of granular cells responsible for water permeability of this epithelium.	Water	175-180	arginine vasopressin	Homo sapiens	29-40
2528228-4	1989	Application of 1 x 10(-3)-1 x 10(-4) M CoCl2 from the mucose part inhibits the vasopressin-stimulated water flow.	Water	102-107	arginine vasopressin	Homo sapiens	79-90
2539747-1	1989	Recent micropuncture studies have demonstrated that administration of high doses of 1-deamino-8-D-arginine vasopressin (dDAVP), a synthetic analogue of vasopressin (AVP), causes desensitization of the thick ascending limb to AVP but may leave unaltered the effect of this hormone on the permeability to water of the collecting duct.	Water	303-308	arginine vasopressin	Rattus norvegicus	107-118
2930796-4	1989	The less active proteinase represents a latent enzyme because it was fully activated by two procedures including dialysis against water and pretreatment with low concentrations of sodium dodecyl sulfate.	Water	130-135	endogenous retrovirus group K member 25	Homo sapiens	16-26
2496763-4	1989	The novel PMR method developed by us is sensitive to the effect of as low as nanogram amounts of t-PA on the interaction between the fibrin and the compartmentalized water trapped in the clot.	Water	166-171	plasminogen activator, tissue type	Homo sapiens	97-101
2539747-1	1989	Recent micropuncture studies have demonstrated that administration of high doses of 1-deamino-8-D-arginine vasopressin (dDAVP), a synthetic analogue of vasopressin (AVP), causes desensitization of the thick ascending limb to AVP but may leave unaltered the effect of this hormone on the permeability to water of the collecting duct.	Water	303-308	arginine vasopressin	Rattus norvegicus	152-163
2759361-3	1989	Water addition increased the peak blood glucose (p less than 0.02) and serum insulin (p less than 0.02) levels in healthy subjects, and the blood glucose concentration in well-controlled diabetic patients (p less than 0.02).	Water	0-5	insulin	Homo sapiens	77-84
2720146-4	1989	And the same application of angiotensin-II 60 min before food and water admission increased by 49% of food intake in hungry rats.	Water	66-71	angiotensinogen	Rattus norvegicus	28-42
2559198-0	1989	Effect of nocodazole on the water permeability response to vasopressin in rabbit collecting tubules perfused in vitro.	Water	28-33	arginine vasopressin	Homo sapiens	59-70
2559198-13	1989	The results are consistent with the view that cytoplasmic microtubules play a role in the initiation of the water permeability response to vasopressin in the mammalian cortical collecting tubule at a cellular site beyond the generation of cyclic AMP.	Water	108-113	arginine vasopressin	Homo sapiens	139-150
2568459-1	1989	Physiochemical parameters have been determined for a series of methotrexate-bovine serum albumin conjugates produced using a water-soluble carbodiimide.	Water	125-130	albumin	Homo sapiens	83-96
2716958-7	1989	VP substitution of the lesioned animals normalized water intake but not plasma osmolality.	Water	51-56	arginine vasopressin	Rattus norvegicus	0-2
2523076-0	1989	Water intake in rats subjected to hypothalamic immunoneutralization of angiotensin II, atrial natriuretic peptide, vasopressin, or oxytocin.	Water	0-5	angiotensinogen	Rattus norvegicus	71-85
2523076-0	1989	Water intake in rats subjected to hypothalamic immunoneutralization of angiotensin II, atrial natriuretic peptide, vasopressin, or oxytocin.	Water	0-5	arginine vasopressin	Rattus norvegicus	115-126
2543099-1	1989	This report shows that purified human alpha-thrombin was able to stimulate a rapid and transient formation of water-soluble phosphorylated 3H-inositols in cultured human umbilical vein endothelial cells (HUVEC) prelabelled with 3H-inositol.	Water	110-115	coagulation factor II, thrombin	Homo sapiens	44-52
2727248-1	1989	Angiotensin II (AII; 300 ng) injected into the lateral cerebral ventricle produced significant drinking responses and also stimulated release of lysine vasopressin (LVP) in conscious, water replete, unrestrained minipigs.	Water	184-189	angiotensinogen	Homo sapiens	0-14
2703526-5	1989	Incorporation of tritiated water into fatty acids in the liver was increased 45% 1-2 h after TNF and 87% at 16-17 h. These results indicate that the TNF-induced increase in circulating lipid levels can occur in the absence of a TNF-induced inhibition of adipose tissue lipoprotein lipase activity.	Water	27-32	lipoprotein lipase	Rattus norvegicus	269-287
2706205-9	1989	This may indicate that cellular immunity has an important role in the pathogenesis of rhodopsin-induced EAU.	Water	104-107	rhodopsin	Homo sapiens	86-95
2722365-1	1989	Increasing levels of nitrate (NO3-) in drinking water in Denmark is of concern due to the possibility of an associated increase in long-term exposure to endogeneously formed N-nitroso compounds.	Water	48-53	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
2722365-3	1989	People drinking nitrate-free water have an intake of 37 mg NO3- per day.	Water	29-34	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
2722365-4	1989	At 47 mg NO3- per litre, the exposure is increased to 89 mg, about 60% of which originates from the water.	Water	100-105	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
2722365-5	1989	At 84 mg NO3- per litre, the daily exposure is 123 mg, 70% of which originates from the drinking water.	Water	97-102	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
2915875-3	1989	A water deprivation study with plasma arginine vasopressin concentrations confirmed the diagnosis and established the efficacy of 1-desamino-8-d-arginine-vasopressin (dDAVP).	Water	2-7	arginine vasopressin	Homo sapiens	47-58
2915875-3	1989	A water deprivation study with plasma arginine vasopressin concentrations confirmed the diagnosis and established the efficacy of 1-desamino-8-d-arginine-vasopressin (dDAVP).	Water	2-7	arginine vasopressin	Homo sapiens	154-165
2501836-4	1989	Moreover, this abnormal water intake is significantly reversed by treatment with Pitressin, a vasopressin analogue.	Water	24-29	arginine vasopressin	Rattus norvegicus	94-105
2705577-0	1989	Osmotic thresholds for AVP release with the use of plasma and urine AVP and free water clearance.	Water	81-86	arginine vasopressin	Homo sapiens	23-26
2730873-1	1989	Structures have been determined for a potent analogue of vasoactive intestinal peptide (VIP), Ac-[Lys12, Lys14, Nle17, Val26, Thr28]VIP (VIP"), in methanol/water solutions.	Water	156-161	vasoactive intestinal peptide	Homo sapiens	88-91
2730873-2	1989	In CD studies, both VIP and VIP" were helical in methanol/water, with the percentage of alpha-helix increasing with percentage methanol.	Water	58-63	vasoactive intestinal peptide	Homo sapiens	20-23
2730873-2	1989	In CD studies, both VIP and VIP" were helical in methanol/water, with the percentage of alpha-helix increasing with percentage methanol.	Water	58-63	vasoactive intestinal peptide	Homo sapiens	28-31
2752065-4	1989	The cytochrome P-450scc-cytochrome b5 complex may be cross-linked with water-soluble carbodiimide.	Water	71-76	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	4-23
2756059-1	1989	Six pony mares deprived of water for 24 hours showed significant increases in plasma vasopressin (2.8 pg/ml) and osmolality (9 mosmol/kg).	Water	27-32	vasopressin	Sus scrofa	85-96
2727248-1	1989	Angiotensin II (AII; 300 ng) injected into the lateral cerebral ventricle produced significant drinking responses and also stimulated release of lysine vasopressin (LVP) in conscious, water replete, unrestrained minipigs.	Water	184-189	angiotensinogen	Homo sapiens	16-19
2727248-3	1989	At the end of the experiment the level was inversely proportional to the volume of water drunk in response to the AII, and not to changes in plasma osmolality.	Water	83-88	angiotensinogen	Homo sapiens	114-117
2742153-5	1989	However, the elution of large sodium dodecyl sulfate-protein complexes and other elongated macromolecules (fibrinogen, tropomyosin) was systematically retarded while polyethylene glycol and polyethylene glycol detergents eluted earlier than water-soluble, globular protein as a function of R eta.	Water	241-246	fibrinogen beta chain	Homo sapiens	107-117
2646141-1	1989	Prednisolone, a water-soluble glucocorticoid hormone, suppressed the secretion of interleukin-1 beta from human peripheral blood mononuclear cells in culture.	Water	16-21	interleukin 1 beta	Homo sapiens	82-100
2920038-3	1989	According to this we can not exclude a difference between the chemical structures of the binding sites that can arise for example from the participation of different forms of the anion and/or water in the two lobes of transferrin.	Water	192-197	transferrin	Homo sapiens	218-229
2647500-0	1989	Human lens membrane proteinase: purification and age-related distributional changes in the water-soluble and insoluble protein fractions.	Water	91-96	endogenous retrovirus group K member 25	Homo sapiens	20-30
2540823-5	1989	These observations at constant temperature are summarized in a quaternary phase diagram for the four-component system CaCl2/PS/PC/water.	Water	130-135	surfactant protein C	Homo sapiens	124-129
2644270-11	1989	In contrast, peak L exhibited an ionization shift and an estimated apparent pKa value similar to that obtained for monomeric FA in water, suggesting that the carboxylate groups of FA bound to L-FABP were solvent accessible and located at or near the protein solvent interface.	Water	131-136	fatty acid binding protein 1	Rattus norvegicus	192-198
2924145-7	1989	Vasopressin replacement normalized water intake in DI rats, but had no significant effect on NK cell activity.	Water	35-40	arginine vasopressin	Rattus norvegicus	0-11
2923975-0	1989	[Protective action of fat- and water-soluble antioxidants on the cytochrome P-450 system during lipid peroxidation in liver microsomes].	Water	31-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-81
2923975-2	1989	It was shown that for optimal protection effect of cytochrome P-450 system the mixture of water and liposoluble antioxidants is required.	Water	90-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	51-67
2539989-2	1989	These stimuli include sulfuric and niric acids, the principal inorganic acids present; sulfites, formed in the atmosphere as a reaction product of sulfur dioxide and water droplets; fog water itself, a hypoosmolar aerosol; the organic acid hydroxymethanesulfonate, the bisulfite adduct of formaldehyde; and gaseous pollutants, e.g., sulfur dioxide, oxides of nitrogen, ozone.	Water	186-191	zinc finger protein, FOG family member 1	Homo sapiens	182-185
2647500-8	1989	A similar Western blot analysis of the water-insoluble proteins from these lenses showed a single protein of 18 kDa that was identified as the subunit of the bovine lens membrane proteinase (Srivastava, 1988a).	Water	39-44	endogenous retrovirus group K member 25	Homo sapiens	179-189
2701149-3	1989	Furthermore, the contribution of prolactin, vasopressin and the renin-angiotensin system to the redistribution of the body fluid compartments after birth and to the regulation of neonatal salt and water metabolism has been demonstrated.	Water	197-202	renin	Homo sapiens	64-69
2542996-11	1989	However, rats treated with desipramine were less active than those treated with tap water or ethanol.	Water	84-89	nuclear RNA export factor 1	Rattus norvegicus	80-83
2523598-0	1989	Water immersion-induced alterations of plasma atrial natriuretic peptide, plasma renin activity, plasma aldosterone, and vasopressin in kidney transplant recipients.	Water	0-5	renin	Homo sapiens	81-86
2523598-0	1989	Water immersion-induced alterations of plasma atrial natriuretic peptide, plasma renin activity, plasma aldosterone, and vasopressin in kidney transplant recipients.	Water	0-5	arginine vasopressin	Homo sapiens	121-132
2912969-4	1989	Application of a deuterium isotope effect of 2.8 led to rate constants in H2O for kC of 0.092 min-1 and kD of 0.73 min-1.	Water	74-77	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
2912969-4	1989	Application of a deuterium isotope effect of 2.8 led to rate constants in H2O for kC of 0.092 min-1 and kD of 0.73 min-1.	Water	74-77	CD59 molecule (CD59 blood group)	Homo sapiens	115-120
2558506-8	1989	These findings suggested that 1) NEP may play a major role in the catabolism of renal KIN in human, 2) NEP is accelerated in PA, 3) unknown K-ase, different from K-ase I, II or NEP, may exist in PA, and 4) accelerated renal K-ase activity may play some role on the disorder of renal water-sodium metabolism and high blood pressure in PA.	Water	283-288	membrane metalloendopeptidase	Homo sapiens	33-36
2524162-0	1989	Effects of water immersion on atrial natriuretic peptide release in humans.	Water	11-16	natriuretic peptide A	Homo sapiens	30-56
2525878-1	1989	The responsiveness of atrial natriuretic factor (ANF) to central volume expansion and its role as a determinant of the natriuretic and diuretic responses of cirrhotic patients was evaluated utilizing water immersion (WI).	Water	200-205	natriuretic peptide A	Homo sapiens	22-47
2536241-3	1989	In the kidney collecting duct, vasopressin induces the cycling of vesicles that are thought to carry water channels to and from the apical plasma membrane of principal cells, thus modulating the water permeability of this membrane.	Water	101-106	arginine vasopressin	Homo sapiens	31-42
2655608-2	1989	Angiotensin II (AII) acts as a potent pressor agent directly, by virtue of its vasoconstrictor activity and indirectly, by the volume expansion resulting from stimulation of aldosterone release from the adrenal cortex, leading to sodium and water retention.	Water	241-246	angiotensinogen	Homo sapiens	0-14
2735650-6	1989	Catalase, which converts H2O2 to H2O, had no effect by itself on cells growing at 20% O2, but it eliminated the superoxide dismutase and glucose oxidase enhancing effects.	Water	25-28	catalase	Homo sapiens	0-8
2912220-3	1989	Rats with lesions of the VLLPBN drank significantly more water during a 30-min test period to both doses of ANG II, but not to carbachol, than did sham lesion rats.	Water	57-62	angiotensinogen	Rattus norvegicus	108-114
2655608-2	1989	Angiotensin II (AII) acts as a potent pressor agent directly, by virtue of its vasoconstrictor activity and indirectly, by the volume expansion resulting from stimulation of aldosterone release from the adrenal cortex, leading to sodium and water retention.	Water	241-246	angiotensinogen	Homo sapiens	16-19
2483679-7	1989	These polypeptides are probably involved in ADH-stimulated water transport and may be components of the water channels.	Water	59-64	arginine vasopressin	Homo sapiens	44-47
2478241-0	1989	Evidence that monensin inhibits vasopressin-stimulated water flow at an early step in the receptor-adenylate cyclase sequence.	Water	55-60	arginine vasopressin	Homo sapiens	32-43
2478241-1	1989	Monensin, a highly selective sodium ionophore, inhibits vasopressin-stimulated water flow in toad urinary bladder pretreated with naproxen, an inhibitor of prostaglandin synthesis.	Water	79-84	arginine vasopressin	Homo sapiens	56-67
2483679-2	1989	In the present study we used an impermeable SH-reagent, a fluorescent maleimide analogue EMA (eosin-5"-maleimide), in order to identify proteins involved in water permeability response to antidiuretic hormone (ADH).	Water	157-162	arginine vasopressin	Homo sapiens	188-208
2804454-0	1989	Water transepithelial transport; mechanisms of action of antidiuretic hormone.	Water	0-5	arginine vasopressin	Homo sapiens	57-77
2804462-1	1989	It is now generally accepted that the increase in water permeability induced by antidiuretic hormone (ADH) in responsive epithelia is accompanied by the insertion of specific structures in the apical membrane of epithelial cells.	Water	50-55	arginine vasopressin	Homo sapiens	80-100
2804462-1	1989	It is now generally accepted that the increase in water permeability induced by antidiuretic hormone (ADH) in responsive epithelia is accompanied by the insertion of specific structures in the apical membrane of epithelial cells.	Water	50-55	arginine vasopressin	Homo sapiens	102-105
2508974-1	1989	Although it is well accepted that vasopressin (ADH) increases the permeability to water of the toad bladder granular cell"s luminal membrane, recent studies have suggested that regulation also takes place at an additional "postluminal" site within the epithelial granular cell.	Water	82-87	arginine vasopressin	Homo sapiens	34-45
2483679-7	1989	These polypeptides are probably involved in ADH-stimulated water transport and may be components of the water channels.	Water	104-109	arginine vasopressin	Homo sapiens	44-47
2508974-5	1989	We attempted to distinguish between these 2 possibilities by studying paired toad bladders during 3 protocols that alter vasopressin-stimulated water flow across the intact tissue without altering aggregate frequency.	Water	144-149	arginine vasopressin	Homo sapiens	121-132
2508977-2	1989	These particle arrays are morphologically indistinguishable from the luminal membrane aggregates which are known to be associated with antidiuretic hormone (ADH)-stimulated water transport.	Water	173-178	arginine vasopressin	Homo sapiens	157-160
2553176-0	1989	Water flow in the toad urinary bladder in response to vasopressin: role of potassium.	Water	0-5	arginine vasopressin	Homo sapiens	54-65
2524219-10	1989	While the temporal relationship between the initial rise in ANF concentration and increase in salt and water excretion suggest that ANF is involved in this diuresis, the role it may play is unclear from the present data.	Water	103-108	natriuretic peptide A	Homo sapiens	132-135
2505889-2	1989	Surface potential (delta V) measurements were performed to assess information on insulin penetration/interaction with dipalmitoylphosphatidylcholine (DPPC) monolayers spread at the water-air interface.	Water	181-186	insulin	Homo sapiens	81-88
2558792-6	1989	In the controls, angiotensin I-converting-enzyme (ACE) inhibition by enalapril significantly reduced the urinary output of sodium and water after ANP infusion.	Water	134-139	angiotensin I converting enzyme	Homo sapiens	17-48
2558792-6	1989	In the controls, angiotensin I-converting-enzyme (ACE) inhibition by enalapril significantly reduced the urinary output of sodium and water after ANP infusion.	Water	134-139	angiotensin I converting enzyme	Homo sapiens	50-53
2691125-1	1989	Renin plays a major role in the control of blood pressure and water and electrolyte metabolism and it is clear that blocking of this system is particularly effective in the treatment of essential hypertension and heart failure.	Water	62-67	renin	Homo sapiens	0-5
2537703-10	1989	The data are consistent with the hypothesis that the increased water and salt excretion in OSA patients is due to increased ANF release.	Water	63-68	natriuretic peptide A	Homo sapiens	124-127
2532119-0	1989	Water-immersion-induced alterations of atrial natriuretic peptide, plasma renin activity, aldosterone and vasopressin in diabetic patients.	Water	0-5	renin	Homo sapiens	74-79
2532119-0	1989	Water-immersion-induced alterations of atrial natriuretic peptide, plasma renin activity, aldosterone and vasopressin in diabetic patients.	Water	0-5	arginine vasopressin	Homo sapiens	106-117
2483679-2	1989	In the present study we used an impermeable SH-reagent, a fluorescent maleimide analogue EMA (eosin-5"-maleimide), in order to identify proteins involved in water permeability response to antidiuretic hormone (ADH).	Water	157-162	arginine vasopressin	Homo sapiens	210-213
2620189-0	1989	Effect of brain natriuretic peptide on dehydration- or angiotensin II-induced water intake in rats.	Water	78-83	natriuretic peptide B	Rattus norvegicus	10-35
2620189-0	1989	Effect of brain natriuretic peptide on dehydration- or angiotensin II-induced water intake in rats.	Water	78-83	angiotensinogen	Rattus norvegicus	55-69
2620189-1	1989	The present study was performed to evaluate the effect of 3rdV injection on water intake of brain natriuretic peptide (BNP), which is structurally different from the atrial natriuretic peptide.	Water	76-81	natriuretic peptide B	Rattus norvegicus	92-117
2620189-1	1989	The present study was performed to evaluate the effect of 3rdV injection on water intake of brain natriuretic peptide (BNP), which is structurally different from the atrial natriuretic peptide.	Water	76-81	natriuretic peptide B	Rattus norvegicus	119-122
2620189-3	1989	Central administration of BNP 3rdV decreased water intake.	Water	45-50	natriuretic peptide B	Rattus norvegicus	26-29
2620189-4	1989	At a dose of 2.0 nmol/rat, BNP partially inhibited dehydration-induced water intake and completely blocked the stimulatory effect of 478 pmol/rat angiotensin II in rats.	Water	71-76	natriuretic peptide B	Rattus norvegicus	27-30
2783663-3	1989	Extubation from a continuous positive airway pressure (CPAP) of 5 cm H2O was associated with a statistically significant rise in cardiac index from 3.44 +/- 0.23 L.min-1.m-2 to 3.73 +/- 0.15 L.min-1.m-2 related to an increase in stroke index, without significant changes in heart rate, mean arterial and pulmonary capillary wedge pressure.	Water	69-72	CD59 molecule (CD59 blood group)	Homo sapiens	164-169
2783663-3	1989	Extubation from a continuous positive airway pressure (CPAP) of 5 cm H2O was associated with a statistically significant rise in cardiac index from 3.44 +/- 0.23 L.min-1.m-2 to 3.73 +/- 0.15 L.min-1.m-2 related to an increase in stroke index, without significant changes in heart rate, mean arterial and pulmonary capillary wedge pressure.	Water	69-72	CD59 molecule (CD59 blood group)	Homo sapiens	193-198
2736581-5	1989	The results show that F absorption from MFP in milk is as high as that of NaF in water under fasting conditions and that the F bioavailability decrease from NaF in water is more important than that of MFP in milk when F ingestion occurs simultaneously with food intake.	Water	81-86	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
2736581-5	1989	The results show that F absorption from MFP in milk is as high as that of NaF in water under fasting conditions and that the F bioavailability decrease from NaF in water is more important than that of MFP in milk when F ingestion occurs simultaneously with food intake.	Water	164-169	C-X-C motif chemokine ligand 8	Homo sapiens	157-160
2691199-2	1989	Bone Gla protein (BGP, osteocalcin) is a 49 residue water soluble protein and matrix Gla protein (MGP) is a 79 residue water insoluble protein.	Water	52-57	bone gamma-carboxyglutamate protein	Rattus norvegicus	0-16
2917956-1	1989	Water immersion produces a marked diuresis, natriuresis, and kaliuresis in association with suppression of the renin-aldosterone system.	Water	0-5	renin	Homo sapiens	111-116
2524388-3	1989	In the two experiments ANF caused comparable elevations in glomerular filtration rate, free water clearance, and lithium excretion.	Water	92-97	natriuretic peptide A	Homo sapiens	23-26
2593764-0	1989	Effects of intraarterial, intravenous, and intraluminal neurotensin on canine ileal sodium and water absorption and blood flow.	Water	95-100	neurotensin	Canis lupus familiaris	56-67
2593764-9	1989	Neurotensin can increase potassium secretion at physiologic levels by a local effect and can increase sodium and water secretion at high physiological-pathological levels through a hormonal mechanism.	Water	113-118	neurotensin	Canis lupus familiaris	0-11
2474096-6	1989	Angiotensin II, by its hemodynamic and tubular effects, modulates renal sodium and water excretion and has an important role in blood pressure regulation.	Water	83-88	angiotensinogen	Homo sapiens	0-14
2474096-9	1989	This suggests that local angiotensin concentrations in the vascular and renin tissues may be more important in determining sodium and water excretion.	Water	134-139	renin	Homo sapiens	72-77
2525217-4	1989	Remarkable bioactivity elicited by BNP rasises the possibility that BNP has a role in the regulation of blood pressure and water-electrolyte balance.	Water	123-128	natriuretic peptide B	Rattus norvegicus	35-38
2525217-4	1989	Remarkable bioactivity elicited by BNP rasises the possibility that BNP has a role in the regulation of blood pressure and water-electrolyte balance.	Water	123-128	natriuretic peptide B	Rattus norvegicus	68-71
2593764-4	1989	Intravenous and intraarterial infusion of neurotensin increased net sodium, potassium, and water secretion, due to increased secretory fluxes, and increased hematocrits.	Water	91-96	neurotensin	Canis lupus familiaris	42-53
2725179-1	1989	When experimental acute gastric mucosal lesions were produced in guinea pig by water-immersion and restraint stress, superoxide dismutase (SOD)-like substance in the plasma increased.	Water	79-84	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	117-137
2725179-1	1989	When experimental acute gastric mucosal lesions were produced in guinea pig by water-immersion and restraint stress, superoxide dismutase (SOD)-like substance in the plasma increased.	Water	79-84	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	139-142
2593764-6	1989	Neurotensin increased potassium secretion at 0.075 micrograms/min IA, increased sodium and water secretion at 0.75 micrograms/min IA and IV, and increased hematocrit at 7.5 micrograms/min IA and and IV.	Water	91-96	neurotensin	Canis lupus familiaris	0-11
2682175-3	1989	The patients in class III, who had profound impairment of water load excretion, were found to have a higher frequency of tense ascites, lower serum sodium concentrations, diuretic resistance, impairment of urinary sodium excretion, lower inulin and p-aminohippurate clearances, and elevations of plasma arginine vasopressin, aldosterone and norepinephrine concentrations.	Water	58-63	arginine vasopressin	Homo sapiens	312-323
2533973-5	1989	In healthy volunteers, however, the same dose of ANF increased urinary excretion of sodium, potassium, calcium, chloride and phosphorus as well as water, and creatinine clearances, and decreased plasma aldosterone.	Water	147-152	natriuretic peptide A	Homo sapiens	49-52
2521696-8	1989	Evidence is also presented to show that ANF depresses distal nephron fractional sodium reabsorption as evaluated both by the lithium method and by estimation of solute-free water clearance.	Water	173-178	natriuretic peptide A	Homo sapiens	40-43
3213443-5	1988	Calcium fluoride-like material, formed on enamel by treatment with 2% NaF solution, was shown by scanning electron microscopy to have higher stability in saliva than in water after 3 weeks" incubation.	Water	169-174	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
2727138-3	1989	Water intake was affected only by the higher dose of AII, with no animals drinking in the 15 minutes following saline or 0.48 nmol AII and 69% of the rats treated with 4.8 nmol AII drinking (mean intake 1.5 +/- 0.26 ml for those rats drinking).	Water	0-5	angiotensinogen	Rattus norvegicus	53-56
2532777-3	1989	The findings indicate that ANP plays a role in intestinal salt and water regulation in man.	Water	67-72	natriuretic peptide A	Homo sapiens	27-30
2904771-8	1988	Our results suggest that an IAP substrate, probably Gi, 1) is required for signal transduction by renal alpha 2-adrenoceptors, 2) may tonically modulate the response to vasopressin in the CCT but not of parathyroid hormone in the proximal convoluted tubule, and 3) participates in renal water and electrolyte reabsorption independent of exogenous adenylate cyclase stimulation.	Water	287-292	arginine vasopressin	Rattus norvegicus	169-180
2463683-8	1989	Intra-arterial substance P at 2.5 x 10(-1) micrograms/min (n = 7) significantly increased the secretion of H2O, Na+, and Cl- (p less than 0.02).	Water	107-110	tachykinin precursor 1	Homo sapiens	15-26
3063282-2	1988	Injections of either angiotensin II (Ang II) or isoproterenol produced very little water intake compared with the robust responses to either intracellular dehydration or to extracellular dehydration induced by treatment with polyethylene glycol (PEG).	Water	83-88	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	21-35
3202189-5	1988	Control animals were given vehicle (0.9% NaCl) by osmotic minipump and they drank tap water.	Water	86-91	nuclear RNA export factor 1	Rattus norvegicus	82-85
2850816-1	1988	Two experiments were performed with Sprague-Dawley rats to study the effects of different inhibitors of angiotensin I converting enzyme (ACE) on water intake and sodium appetite.	Water	145-150	angiotensin I converting enzyme	Rattus norvegicus	104-135
2850816-1	1988	Two experiments were performed with Sprague-Dawley rats to study the effects of different inhibitors of angiotensin I converting enzyme (ACE) on water intake and sodium appetite.	Water	145-150	angiotensin I converting enzyme	Rattus norvegicus	137-140
3264461-4	1988	Our results fully confirm that after microtubular network disruption, antidiuretic hormone-induced water permeability variations undergo typical alterations consisting in both a reduction in peak net water flow and a slowing down of its onset.	Water	99-104	arginine vasopressin	Homo sapiens	70-90
3264461-4	1988	Our results fully confirm that after microtubular network disruption, antidiuretic hormone-induced water permeability variations undergo typical alterations consisting in both a reduction in peak net water flow and a slowing down of its onset.	Water	200-205	arginine vasopressin	Homo sapiens	70-90
2907483-9	1988	In contrast, cytochalasin B alone and in combination with fMLP induces a considerable decrease of non-polar cells and an increase of spherical cells similar to non-stimulated cells in H2O-based medium.	Water	184-187	formyl peptide receptor 1	Homo sapiens	58-62
2975995-1	1988	The possible interaction between arginine vasopressin (AVP) and atrial natriuretic factor (ANF) in the control of urinary sodium and water excretion was investigated in man.	Water	133-138	arginine vasopressin	Homo sapiens	55-58
2848782-2	1988	For example, ground water in the surficial aquifer of central Florida commonly has gross-alpha radioactivity in excess of 555 Bq m-3 (15 pCi L-1).	Water	20-25	immunoglobulin kappa variable 1-16	Homo sapiens	141-144
2975995-1	1988	The possible interaction between arginine vasopressin (AVP) and atrial natriuretic factor (ANF) in the control of urinary sodium and water excretion was investigated in man.	Water	133-138	natriuretic peptide A	Homo sapiens	91-94
2975995-4	1988	Atrial natriuretic factor caused a significant increase in sodium excretion (UNaV) [+56%], urinary flow rate (V) [+17%] and free water clearance (CH2O) [+23%]; creatinine clearance (Ccr) did not change.	Water	129-134	natriuretic peptide A	Homo sapiens	0-25
2849664-13	1988	The increase in water excretion at the lower infusion rates would be consistent with the antagonism of the renal effects of vasopressin.	Water	16-21	arginine vasopressin	Rattus norvegicus	124-135
2855944-0	1988	[Effect of water immersion (WI) on serum levels of ACTH and cortisol in patients with simple obesity].	Water	11-16	proopiomelanocortin	Homo sapiens	51-55
3149997-0	1988	The photoreaction of vacuum-dried rhodopsin at low temperature: evidence for charge stabilization by water.	Water	101-106	rhodopsin	Homo sapiens	34-43
3149997-5	1988	The direct involvement of water in the retinal binding site was demonstrated by measuring the rhodopsin-bathorhodopsin FTIR difference spectra of rhodopsin hydrated with H2O and H2(18)O.	Water	26-31	rhodopsin	Homo sapiens	94-103
3149997-5	1988	The direct involvement of water in the retinal binding site was demonstrated by measuring the rhodopsin-bathorhodopsin FTIR difference spectra of rhodopsin hydrated with H2O and H2(18)O.	Water	26-31	rhodopsin	Homo sapiens	109-118
3149997-5	1988	The direct involvement of water in the retinal binding site was demonstrated by measuring the rhodopsin-bathorhodopsin FTIR difference spectra of rhodopsin hydrated with H2O and H2(18)O.	Water	170-173	rhodopsin	Homo sapiens	94-103
3149997-5	1988	The direct involvement of water in the retinal binding site was demonstrated by measuring the rhodopsin-bathorhodopsin FTIR difference spectra of rhodopsin hydrated with H2O and H2(18)O.	Water	170-173	rhodopsin	Homo sapiens	109-118
3141635-2	1988	The water content of the sural nerve of diabetic patients was quantitatively defined by magnetic resonance proton imaging as a putative reflection of activity of the aldose-reductase pathway.	Water	4-9	aldo-keto reductase family 1 member B	Homo sapiens	166-182
3141635-6	1988	Symptomatic diabetics treated with aldose-reductase inhibitors had normal nerve water levels.	Water	80-85	aldo-keto reductase family 1 member B	Homo sapiens	35-51
3205922-2	1988	The device is connected either to a percutaneous biliary drainage catheter or to a fibroscope, and provides a high-frequency pulsating water jet.	Water	135-140	F-box and leucine rich repeat protein 15	Homo sapiens	141-144
2847727-3	1988	Sulfonated phenyl isothiocyanate cytochrome c is water and salt soluble.	Water	49-54	cytochrome c, somatic	Homo sapiens	33-45
3145979-4	1988	The refined model includes residues 5 to 147, four Ca2+ and 69 water molecules per molecule of calmodulin.	Water	63-68	calmodulin 1	Homo sapiens	95-105
3229009-0	1988	Effect of pH on vasopressin-induced water permeability in collecting ducts of isolated rat papillae.	Water	36-41	arginine vasopressin	Rattus norvegicus	16-27
3229009-7	1988	In the presence of 50 microU/ml vasopressin, increases in diffusional water permeability of collecting ducts perfused with solutions at pH 5.0, 7.4 or 9.0 did not differ significantly.	Water	70-75	arginine vasopressin	Rattus norvegicus	32-43
3229009-8	1988	Similarly, increases in diffusional water permeability induced by 200 microU/ml vasopressin were not different when collecting ducts were perfused with solutions at pH 5.0, 7.4 or 9.0.	Water	36-41	arginine vasopressin	Rattus norvegicus	80-91
3229009-10	1988	The presence of vasopressin (50 microU/ml) in the bathing medium at pH 6.4, 7.4 and 8.4 induced increments in diffusional water permeability of 0.40 +/- 0.21 (n = 14, P greater than 0.05), 1.56 +/- 0.27 (n = 27, P less than 0.001) and 1.67 +/- 0.24 (n = 12, P less than 0.001) microns/s, respectively.	Water	122-127	arginine vasopressin	Rattus norvegicus	16-27
3229009-13	1988	The presence of vasopressin (200 microU/ml) in the bathing medium at pH 6.4, 7.4 and 8.4 induced increments in diffusional water permeability of 2.16 +/- 0.54 (n = 9, P less than 0.01), 2.55 +/- 0.51 (n = 17, P less than 0.001) and 0.98 +/- 0.34 (n = 11, P less than 0.05) microns/s respectively.	Water	123-128	arginine vasopressin	Rattus norvegicus	16-27
24425244-5	1988	Water saving is more likely to be significant during CAM-idling when water supply is limited and stomata are closed day and night.	Water	0-5	calmodulin 3	Homo sapiens	53-56
24425244-5	1988	Water saving is more likely to be significant during CAM-idling when water supply is limited and stomata are closed day and night.	Water	69-74	calmodulin 3	Homo sapiens	53-56
3205922-5	1988	The water jet allows the mobilization of even the biggest stones and the elimination of stone debris, as well as the removing of fibrin and necrotic tissue fragments tightly attached to bile duct walls in subacute cholangitis.	Water	4-9	F-box and leucine rich repeat protein 15	Homo sapiens	10-13
3242951-7	1988	Our model also explains the facilitation of precipitation observed when phosphatidylcholine is contained in the palmitate-bile salt mixed micelles and the inhibitory effect of the water soluble bovine serum albumin.	Water	180-185	albumin	Homo sapiens	201-214
3233207-19	1988	In DMPG the sn-1 C = O group seems to be more accessible to water, indicating a different conformation of the glycerol backbone.	Water	60-65	solute carrier family 38 member 3	Homo sapiens	12-16
2973849-7	1988	hANP caused a small change in fractional lithium clearance, and larger changes in distal nephron handling of sodium and water.	Water	120-125	natriuretic peptide A	Homo sapiens	0-4
2973849-11	1988	The data suggest that hANP inhibits the reabsorption of sodium and water by an action on distal segments of the nephron and perhaps the proximal tubule.	Water	67-72	natriuretic peptide A	Homo sapiens	22-26
3179304-0	1988	Interaction between a growth-hormone releasing hexapeptide and phospholipids spread as monolayers at the air/water interface.	Water	109-114	growth hormone 1	Homo sapiens	22-36
2854253-0	1988	[Effect of water immersion on serum levels of ACTH and cortisol in patients with chronic renal failure and in healthy persons].	Water	11-16	proopiomelanocortin	Homo sapiens	46-50
2972348-9	1988	Positive-pressure ventilation may decrease the release of ANF by decreasing venous return and thus contribute to water retention.	Water	113-118	natriuretic peptide A	Homo sapiens	58-61
3181734-1	1988	Prolactin secretion is stimulated markedly in fish exposed to water of pH 4.	Water	62-67	prolactin	Sus scrofa	0-9
3181734-4	1988	After acute acidification of the water, which leads to a substantial fall in plasma osmolarity and plasma electrolyte levels, the activation of the prolactin cells is less marked than after gradual acidification of the water, when plasma osmolarity, plasma sodium, and plasma total and ionic calcium levels are not noticeably affected.	Water	33-38	prolactin	Sus scrofa	148-157
3181734-4	1988	After acute acidification of the water, which leads to a substantial fall in plasma osmolarity and plasma electrolyte levels, the activation of the prolactin cells is less marked than after gradual acidification of the water, when plasma osmolarity, plasma sodium, and plasma total and ionic calcium levels are not noticeably affected.	Water	219-224	prolactin	Sus scrofa	148-157
3181734-5	1988	When fish bearing an implanted rostral pars distalis of the pituitary gland are exposed to water of pH 4, both the in situ prolactin cells and the prolactin cells of the implant become activated only when the drop in water pH is acute and followed by a reduction in plasma osmolarity and electrolyte levels.	Water	91-96	prolactin	Sus scrofa	123-132
3181734-5	1988	When fish bearing an implanted rostral pars distalis of the pituitary gland are exposed to water of pH 4, both the in situ prolactin cells and the prolactin cells of the implant become activated only when the drop in water pH is acute and followed by a reduction in plasma osmolarity and electrolyte levels.	Water	91-96	prolactin	Sus scrofa	147-156
3181734-7	1988	We conclude that the activation of the prolactin cells in situ in fish in acid water is not mediated by reductions in plasma osmolarity, plasma sodium, total calcium, or ionic calcium, but by hypothalamic mechanisms.	Water	79-84	prolactin	Sus scrofa	39-48
2844855-9	1988	ANF appears to act at a site distal to cyclic AMP generation in the chain of events linking vasopressin receptor binding to an increase in osmotic water permeability.	Water	147-152	arginine vasopressin	Rattus norvegicus	92-103
2844855-0	1988	Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.	Water	66-71	arginine vasopressin	Rattus norvegicus	35-46
3062061-11	1988	Thus, the absence of vasopressin in female Brattleboro rats severely affects cardiovascular adaptation to water deprivation.	Water	106-111	arginine vasopressin	Rattus norvegicus	21-32
3062573-3	1988	A significant reduction of water intake was observed when angiotensin I converting enzyme was inhibited by captopril and enalapril.	Water	27-32	angiotensin I converting enzyme	Rattus norvegicus	58-89
2974116-9	1988	Consequently, plasma alpha hANP level plays an important role in water-electrolyte metabolism during the perioperative period.	Water	65-70	natriuretic peptide A	Homo sapiens	27-31
2843050-1	1988	This review focuses on events at the apical plasma membrane of toad urinary bladder and mammalian collecting duct as their permeability to water changes in response to antidiuretic hormone (ADH) and to its withdrawal.	Water	139-144	arginine vasopressin	Homo sapiens	168-194
2459709-1	1988	Simulation of the molecular dynamics of a small protein, bovine pancreatic trypsin inhibitor, was found to be more realistic when water molecules were included than when in vacuo: the time-averaged structure was much more like that observed in high-resolution x-ray studies, the amplitudes of atomic vibration in solution were smaller, and fewer incorrect hydrogen bonds were formed.	Water	130-135	trophoblast Kunitz domain protein 1	Bos taurus	75-92
3061458-6	1988	In the second part, we introduce a simple fluorescence technique by which adsorption isotherms of water-soluble and fluorescent-labeled substrates, such as insulin, to membranes may be determined.	Water	98-103	insulin	Homo sapiens	156-163
3421968-0	1988	Lysozyme kinetics in low water activity media.	Water	25-30	lysozyme	Homo sapiens	0-8
3421968-2	1988	The influence of water activity on initial lysozyme kinetics is studied.	Water	17-22	lysozyme	Homo sapiens	43-51
3421968-4	1988	This influence of water organization on initial enzyme activity is immediate and may be preserved even after a large dilution, thus lysozyme presents a "hydration memory" phenomenon.	Water	18-23	lysozyme	Homo sapiens	132-140
2843239-2	1988	Fourier transform infrared spectra of apolipoprotein E-depleted human HDL3 have been obtained in H2O and 2H2O buffers.	Water	97-100	apolipoprotein E	Homo sapiens	38-54
2843239-2	1988	Fourier transform infrared spectra of apolipoprotein E-depleted human HDL3 have been obtained in H2O and 2H2O buffers.	Water	97-100	HDL3	Homo sapiens	70-74
3143405-7	1988	PKC alone (in the absence of PL) formed a film at the air-water interface with a surface pressure of about 26 dyn/cm.	Water	58-63	proline rich transmembrane protein 2	Homo sapiens	0-3
3143405-8	1988	Calcium-dependent binding was studied at the higher surface pressures which effectively excluded PKC from the air-water interface.	Water	114-119	proline rich transmembrane protein 2	Homo sapiens	97-100
2843050-3	1988	Withdrawal of ADH is accompanied by endocytosis at the apical membrane, reflecting retrieval of water-permeable, particle aggregate-containing membrane.	Water	96-101	arginine vasopressin	Homo sapiens	14-17
2484355-2	1988	The activities of delta-aminolevulinic acid dehydratase in blood were decreased in the group given 10 micrograms lead acetate/mL in their drinking water and fed the semipurified diet, but not in the blood from the group treated with lead and fed the pelleted diet.	Water	147-152	aminolevulinate dehydratase	Rattus norvegicus	18-55
3414846-5	1988	Variable water intake in response to 25, 50, and 75 ng ANG II.kg-1.min-1 after a relatively long latency to drink (40-65 min) was observed.	Water	9-14	angiotensinogen	Rattus norvegicus	55-61
3145339-1	1988	Osmotic water permeability of the apical membrane of toad urinary epithelium is increased greatly by vasopressin (VP) and is associated with exocytic addition of granules and aggrephores at the apical surface.	Water	8-13	arginine vasopressin	Homo sapiens	101-112
3179188-2	1988	When administered as two separate injections over a 24 h period (acute administration) TNF produced a dose-related weight reduction that was accompanied by and directly proportional to a decrease in both food and water intake.	Water	213-218	tumor necrosis factor	Homo sapiens	87-90
3179188-7	1988	Acute administration of TNF also induced a decrease in the total body water content of treated animals which was similar to pair-fed controls.	Water	70-75	tumor necrosis factor	Homo sapiens	24-27
3179188-8	1988	It is concluded that the weight loss produced by TNF arises from a combination of semi-starvation and a reduced water intake, and that the effect only occurred with the first administration of TNF.	Water	112-117	tumor necrosis factor	Homo sapiens	49-52
2969791-7	1988	Our data suggest that CPAP at 20 cm H2O lowers the release of ANP in volume-expanded subjects.	Water	36-39	natriuretic peptide A	Homo sapiens	62-65
3145339-1	1988	Osmotic water permeability of the apical membrane of toad urinary epithelium is increased greatly by vasopressin (VP) and is associated with exocytic addition of granules and aggrephores at the apical surface.	Water	8-13	arginine vasopressin	Homo sapiens	114-116
2847071-0	1988	Neurokinin A selectively inhibits water intake in the rat.	Water	34-39	tachykinin precursor 1	Homo sapiens	0-12
3216721-0	1988	Vasopressin and oxytocin excretion in the Brown-Norway rat in relation to aging, water metabolism and testosterone.	Water	81-86	arginine vasopressin	Rattus norvegicus	0-11
3244565-1	1988	Spontaneously hypertensive rats (SHR) revealed exaggerated water consumption to the intracerebroventricular (ICV) infusion of angiotensin II (AII), and angiotensin III (AIII), as compared with Wistar-Kyoto (WKY) and Sprague-Dawley (SD) normotensive rat strains, in agreement with an earlier report (30) that employed ICV bolus injections of AII and AIII.	Water	59-64	angiotensinogen	Rattus norvegicus	126-140
3244565-1	1988	Spontaneously hypertensive rats (SHR) revealed exaggerated water consumption to the intracerebroventricular (ICV) infusion of angiotensin II (AII), and angiotensin III (AIII), as compared with Wistar-Kyoto (WKY) and Sprague-Dawley (SD) normotensive rat strains, in agreement with an earlier report (30) that employed ICV bolus injections of AII and AIII.	Water	59-64	angiotensinogen	Rattus norvegicus	142-145
3244565-4	1988	In contrast, ICV infusion of AII yielded greater water intake than AIII in members of each strain tested.	Water	49-54	angiotensinogen	Rattus norvegicus	29-32
3400402-4	1988	In healthy subjects plasma AVP increased both when they were normohydrated and after they had been water-depleted.	Water	99-104	arginine vasopressin	Homo sapiens	27-30
3154522-7	1988	We conclude that the combination of polydipsia and abnormal osmoregulation of vasopressin secretion contributes importantly to the afternoon hyponatremia found in schizophrenic patients subject to water intoxication.	Water	197-202	arginine vasopressin	Homo sapiens	78-89
2847775-1	1988	Upon incubation of detergent-solubilized NADPH-cytochrome P-450 reductase and either cytochrome b5 or cytochrome c in the presence of a water-soluble carbodiimide, a 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC), covalently cross-linked complex was formed.	Water	136-141	cytochrome p450 oxidoreductase	Homo sapiens	41-73
2847775-1	1988	Upon incubation of detergent-solubilized NADPH-cytochrome P-450 reductase and either cytochrome b5 or cytochrome c in the presence of a water-soluble carbodiimide, a 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC), covalently cross-linked complex was formed.	Water	136-141	cytochrome c, somatic	Homo sapiens	102-114
2847584-3	1988	Upon addition of bee venom phospholipase A2, the water-soluble product, 4-doxylpentanoic acid, is released which brings about a sharp three-line spectrum.	Water	49-54	phospholipase A2 group IB	Homo sapiens	27-43
3137698-7	1988	It is concluded that cytochrome P-450 initiated this novel reaction by the formation of an N-hydroxylamine, followed by a non-P-450-mediated attack of water causing the removal of nitrous acid and the formation of the phenol.	Water	151-156	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	21-37
3407802-6	1988	The results suggest that oropharyngeal factors inhibiting vasopressin release, revealed during saline ingestion, are obscured during normal rehydration as a result of the rapid rate at which water is absorbed by the gut in this species.	Water	191-196	vasopressin	Sus scrofa	58-69
2844547-2	1988	Central volume stimulation by 1-h head-out water immersion (WI) into a thermoneutral water-bath increased plasma levels of ANF (mean +/- SEM) from 6.0 +/- 0.6 to 13.6 +/- 2.6 fmol ml-1.	Water	43-48	natriuretic peptide A	Homo sapiens	123-126
2844547-2	1988	Central volume stimulation by 1-h head-out water immersion (WI) into a thermoneutral water-bath increased plasma levels of ANF (mean +/- SEM) from 6.0 +/- 0.6 to 13.6 +/- 2.6 fmol ml-1.	Water	85-90	natriuretic peptide A	Homo sapiens	123-126
2844547-4	1988	Water immersion reduced plasma aldosterone concentration (PAC) from 13.0 +/- 1.7 to 6.5 +/- 0.8 ng 100 ml-1 and plasma renin activity (PRA) from 5.3 +/- 0.9 to 2.4 +/- 0.3 ng AI ml-1 h-1.	Water	0-5	renin	Homo sapiens	119-124
3054115-0	1988	The role of membrane turnover in the water permeability response to antidiuretic hormone.	Water	37-42	arginine vasopressin	Homo sapiens	68-88
2905268-0	1988	Disparate effects of neuropeptide Y and clonidine on the excretion of sodium and water in the rat.	Water	81-86	neuropeptide Y	Rattus norvegicus	21-35
3176582-2	1988	We observed an excessive augmentation of AVP excretion in 24 h urine in 9 patients receiving high-dose methotrexate combined with a considerable water retention.	Water	145-150	arginine vasopressin	Homo sapiens	41-44
3223284-0	1988	Oral therapeutic system delivering a water insoluble drug: N-(4-[2-(3-methylpyrazole-1-carbonamide)ethyl]-benzenesulfonyl)N - cyclohexylurea (SPC-5002).	Water	37-42	proline rich protein gene cluster	Homo sapiens	142-145
3234884-2	1988	Effect of water immersion on blood vasopressin and plasma molality].	Water	10-15	arginine vasopressin	Homo sapiens	35-46
3069620-2	1988	Effect of water immersion on changes in the renin-angiotensin-aldosterone system in normal pregnancy and EPH gestosis].	Water	10-15	renin	Homo sapiens	44-49
2848236-2	1988	Being added from the mucous or serous membranes, Ca channel blocker (fendiline) and calmodulin antagonist (thioridazine) inhibit the water effect of ADH.	Water	133-138	calmodulin 1	Homo sapiens	84-94
3169037-1	1988	In target epithelia, a vasopressin-induced water permeability increase is accompanied by the appearance of intramembranous particle (IMP) clusters, probably representing water-permeable patches, in the apical plasma membrane of responding cells.	Water	43-48	arginine vasopressin	Rattus norvegicus	23-34
3271622-8	1988	These results differ from our findings in normal man in whom VIP diminished water and electrolyte secretion largely by increasing tubular reabsorption.	Water	76-81	vasoactive intestinal peptide	Homo sapiens	61-64
3169037-1	1988	In target epithelia, a vasopressin-induced water permeability increase is accompanied by the appearance of intramembranous particle (IMP) clusters, probably representing water-permeable patches, in the apical plasma membrane of responding cells.	Water	170-175	arginine vasopressin	Rattus norvegicus	23-34
3403426-2	1988	A positive balance of Na was also observed in the 0.45 (approximately 250%) and 2.0% NaCl groups (300%), whereas the 0.2% NaCl group regained lost water and Na simultaneously at 10 h. With tap water, additional loss of cations was observed.	Water	193-198	nuclear RNA export factor 1	Rattus norvegicus	189-192
3164706-4	1988	Relative to values in water-drinking rats without Ang II infusion, Ang II-salt hypertensive rats exhibited augmentation (p less than 0.05) of blood pressure (from 129 +/- 3 to 217 +/- 12 mm Hg), urinary thromboxane B2 excretion (from 5.4 +/- 0.9 to 25.4 +/- 2.1 ng/day), and thromboxane B2 release from renal cortex slices (from 71.3 +/- 6.7 to 121.1 +/- 14.4 pg/mg) and aortic rings (from 28.8 +/- 2.9 to 115.8 +/- 12.8 pg/mg).	Water	22-27	angiotensinogen	Rattus norvegicus	67-73
3368004-0	1988	Endosomes from kidney collecting tubule cells contain the vasopressin-sensitive water channel.	Water	80-85	arginine vasopressin	Homo sapiens	58-69
2838523-1	1988	UNLABELLED: Vasopressin increases both the urea permeability and osmotic water permeability in the terminal part of the renal inner medullary collecting duct (terminal IMCD).	Water	73-78	arginine vasopressin	Rattus norvegicus	12-23
2838523-4	1988	Half-maximal increases in urea permeability and osmotic water permeability occurred with 0.01 nM vasopressin.	Water	56-61	arginine vasopressin	Rattus norvegicus	97-108
3175333-1	1988	The binding stoichiometry and equilibria of three polycationic water-soluble porphyrins with human serum albumin (HSA) have been determined by fluorescence quenching and filtration methods in 0.1M phosphate buffer, pH 7.2 at 25 degrees.	Water	63-68	albumin	Homo sapiens	99-118
2969822-2	1988	administration of brain natriuretic peptide (BNP) on water drinking was studied in rats.	Water	53-58	natriuretic peptide B	Rattus norvegicus	18-43
2969822-2	1988	administration of brain natriuretic peptide (BNP) on water drinking was studied in rats.	Water	53-58	natriuretic peptide B	Rattus norvegicus	45-48
2969822-4	1988	injection of BNP at a dose of 1.5 nmol elicited no apparent change in spontaneous water intake in rats but significantly attenuated the water intake induced by the i.c.v.	Water	136-141	natriuretic peptide B	Rattus norvegicus	13-16
2969822-7	1988	These findings suggest that BNP could play a role in the regulation of water intake in the central nervous system, either alone or in concert with brain ANP.	Water	71-76	natriuretic peptide B	Rattus norvegicus	28-31
3371358-4	1988	From turbidity measurements at 450 nm it is obvious that fibrinogen is soluble in a slightly more narrow range of NaCl concentration and that the fibrin gels have a higher degree of lateral aggregation in D2O than in H2O.	Water	217-220	fibrinogen beta chain	Homo sapiens	57-67
3368004-1	1988	The mechanism by which vasopressin rapidly and dramatically increases the water permeability of target epithelial cell membranes is thought to involve a cycle of exo- and endocytosis during which vesicles carrying "water channels" are successively inserted into, and removed from the apical plasma membrane of epithelial cells.	Water	74-79	arginine vasopressin	Homo sapiens	23-34
3368004-4	1988	There has been no direct evidence, however, that subcellular membranes in vasopressin-sensitive epithelia contain functional water channels.	Water	125-130	arginine vasopressin	Homo sapiens	74-85
3368004-6	1988	We present direct evidence that vasopressin induces the appearance of a population of endocytic vesicles whose limiting membranes contain water channels.	Water	138-143	arginine vasopressin	Homo sapiens	32-43
3371358-5	1988	The variation of fibrinogen concentration, thrombin concentration, pH and ionic a strength have a similar dependence on the final gel structure and clotting time in D2O and H2O.	Water	173-176	fibrinogen beta chain	Homo sapiens	17-27
3371358-5	1988	The variation of fibrinogen concentration, thrombin concentration, pH and ionic a strength have a similar dependence on the final gel structure and clotting time in D2O and H2O.	Water	173-176	coagulation factor II, thrombin	Homo sapiens	43-51
3371358-7	1988	The alpha-chain cross-linking was somewhat faster in D2O than in H2O.	Water	65-68	Fc gamma receptor and transporter	Homo sapiens	4-15
3371358-10	1988	The differences in solubility for fibrinogen, kinetics for the enzyme reaction and optical properties for the fibrin gels in D2O and H2O may be explained by differences in electrostatic interactions, hydrogen bonding and hydration of fibrinogen in these two media.	Water	133-136	fibrinogen beta chain	Homo sapiens	234-244
3365431-0	1988	Kinetics of binding of phospholipase A2 to lipid/water interfaces and its relationship to interfacial activation.	Water	49-54	phospholipase A2 group IB	Homo sapiens	23-39
3364580-1	1988	The origin of the vacuoles that form in the mammalian collecting duct during antidiuretic hormone (ADH)-mediated water reabsorption was examined using two computer-assisted, light microscopic methods.	Water	113-118	arginine vasopressin	Homo sapiens	77-97
3364580-1	1988	The origin of the vacuoles that form in the mammalian collecting duct during antidiuretic hormone (ADH)-mediated water reabsorption was examined using two computer-assisted, light microscopic methods.	Water	113-118	arginine vasopressin	Homo sapiens	99-102
3284386-5	1988	Exogenous LPL bound in the liver caused a dramatic increase in the utilization of a perfused triacylglycerol emulsion (Intralipid), with rapid formation of free fatty acids and water-soluble metabolites.	Water	177-182	lipoprotein lipase	Rattus norvegicus	10-13
3364580-8	1988	These results indicate that most vacuoles that form during ADH-mediated water reabsorption are intracellular, endocytic compartments that communicate with the peritubular space via endocytosis of basolateral cell membrane.	Water	72-77	arginine vasopressin	Homo sapiens	59-62
3386517-1	1988	We have studied the effects of two diuretics, selective for renal cortical (furosemide) and inner medullary (vasopressin antagonist) water handling, in rat kidney at 1.5 T and find that furosemide completely dissipates the cortical-inner medullary T2 gradient whereas the vasopressin antagonist has little effect.	Water	133-138	arginine vasopressin	Rattus norvegicus	109-120
3420014-9	1988	In contrast, the chronic infusion of AVP in Brattleboro rats resulted in a reduction in water intake which was accompanied by a decreased Bmax.	Water	88-93	arginine vasopressin	Rattus norvegicus	37-40
3188650-3	1988	Microinjections of dipsogenic peptide angiotensin II, unlike acetylcholine administration, do not initiate taking of water or alcohol, but elicit only appearance of orienting-investigating, alimentary, sexual and other behavioural reactions.	Water	117-122	angiotensinogen	Rattus norvegicus	38-52
3128334-0	1988	A comparison of the surface activities of human apolipoproteins A-I and A-II at the air/water interface.	Water	88-93	apolipoprotein A1	Homo sapiens	48-76
3128334-1	1988	Surface pressure (pi) and adsorption isotherms for human apolipoproteins A-I and A-II at the air/water interface have been determined and used to deduce the probable molecular structures of the monomolecular films.	Water	97-102	apolipoprotein A1	Homo sapiens	57-85
3384004-2	1988	In this study, the brain peptides bombesin and angiotensin II were examined for their ability to alter water flux across the small intestine after their intracerebroventricular (i.c.v.)	Water	103-108	angiotensinogen	Rattus norvegicus	47-61
2834226-1	1988	The oxidised (ferric-cupric) binuclear centre of cytochrome oxidase is converted into two other states, presumably ferrylcupric (F) and ferric-peroxy-cupric (P), by energy-dependent reversed electron transfer from the centre (and water) to cytochrome c [(1981) Proc.	Water	230-235	cytochrome c, somatic	Homo sapiens	240-252
2833121-1	1988	Adenosine 3",5"-cyclic monophosphate (cAMP)-dependent protein phosphorylation is considered a key step in the cellular action of vasopressin (AVP) to regulate water permeability in collecting tubules.	Water	159-164	arginine vasopressin	Rattus norvegicus	129-140
3382624-0	1988	Influence of the structure of the lipid-water interface on the activity of hepatic lipase.	Water	40-45	lipase C, hepatic type	Rattus norvegicus	75-89
3390373-2	1988	Tumour necrosis factor-alpha (TNF-alpha) produced a dose-related weight reduction that was accompanied by a decrease in both food and water intake.	Water	134-139	tumor necrosis factor	Mus musculus	30-39
3354688-1	1988	Water drinking suppresses arginine vasopressin (AVP) release before changes in tonicity or volume.	Water	0-5	arginine vasopressin	Homo sapiens	35-46
3354688-1	1988	Water drinking suppresses arginine vasopressin (AVP) release before changes in tonicity or volume.	Water	0-5	arginine vasopressin	Homo sapiens	48-51
3395643-2	1988	A comparison of physico-chemical properties of the fluorocarbons revealed that their activity as cytochrome P-450 inducers is determined by their solubility in H2O and lipids as well as by the pressure of their saturated vapours at 37 degrees C. The fluorocarbons capable of inducing cytochrome P-450 have a molecular mass of 400-550 Da.	Water	160-163	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	97-113
3395862-2	1988	In the present study, the effect of chronic subcutaneous infusions of AII on: (1) the binding of AII to neuronal membranes from the diencephalon (hypothalamus, thalamus and septum) (HTS) of the brain; (b) water intake and urine output, (c) blood pressure, and (d) their interrelationships was evaluated in rats.	Water	205-210	angiotensinogen	Rattus norvegicus	70-73
3395862-2	1988	In the present study, the effect of chronic subcutaneous infusions of AII on: (1) the binding of AII to neuronal membranes from the diencephalon (hypothalamus, thalamus and septum) (HTS) of the brain; (b) water intake and urine output, (c) blood pressure, and (d) their interrelationships was evaluated in rats.	Water	205-210	angiotensinogen	Rattus norvegicus	97-100
3395862-3	1988	Significant increases in daily water intake and urine output accompanied chronic infusions of AII at a rate of 125 ng/kg/min.	Water	31-36	angiotensinogen	Rattus norvegicus	94-97
2965633-0	1988	Effects of angiotensin II and atrial natriuretic peptide alone and in combination on urinary water and electrolyte excretion in man.	Water	93-98	angiotensinogen	Homo sapiens	11-25
2965633-0	1988	Effects of angiotensin II and atrial natriuretic peptide alone and in combination on urinary water and electrolyte excretion in man.	Water	93-98	natriuretic peptide A	Homo sapiens	30-56
2974798-1	1988	To examine a possible role of atrial natriuretic peptide (ANP) in water and electrolyte disturbances associated with thyroid disorders, plasma ANP levels were studied in patients with hyper- and hypothyroidism.	Water	66-71	natriuretic peptide A	Homo sapiens	58-61
2830903-6	1988	Experiments employing REF52 cells prelabeled with [3H]choline demonstrated that both TPA and vasopressin induce the hydrolysis of cellular choline-containing glycerophospholipids; this was measured by both a decrease in cell-associated phosphatidylcholine radioactivity and an increase in the production of water-soluble [3H]choline-containing metabolites in the culture medium.	Water	307-312	arginine vasopressin	Rattus norvegicus	93-104
3255369-0	1988	Orientation of the water molecules of hydration of human serum albumin.	Water	19-24	albumin	Homo sapiens	57-70
3127945-7	1988	About 5 mumol of 18O per gram of dry liver was incorporated in phenobarbital/CCl4-treated rats, of which 60% was in the water-soluble fraction, 17% in the lipids, and 16% in the macromolecules.	Water	120-125	C-C motif chemokine ligand 4	Rattus norvegicus	77-81
3285068-7	1988	Chronic administration of DOCA (1 mg/kg s.c.) and saline drinking water which increased sodium and solute excretions and decreased plasma renin activity also prevented the decrease in GFR.	Water	66-71	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	138-143
2964780-4	1988	Plasma ANF level and urinary sodium excretion increased during water retention, whereas plasma aldosterone value decreased later.	Water	63-68	natriuretic peptide A	Homo sapiens	7-10
2964780-6	1988	In two patients with hyponatremia due to SIADH, plasma ANF levels were increased during the hyponatremic phase of their condition and decreased under water restriction.	Water	150-155	natriuretic peptide A	Homo sapiens	55-58
2964780-8	1988	It is concluded that secretion of ANF is acutely and chronically stimulated during water retention in SIADH and that ANF may be in part responsible for the natriuresis encountered in inappropriate antidiuresis.	Water	83-88	natriuretic peptide A	Homo sapiens	34-37
3287209-3	1988	This angiotensin II-induced intake of water was markedly inhibited by [Sar1, Ile8]-angiotensin II, an angiotensin II receptor antagonist, but not by captopril, an angiotensin-converting enzyme inhibitor, previously administered through the same cannula.	Water	38-43	angiotensinogen	Rattus norvegicus	83-97
3177653-7	1988	We propose that histidine increases the hydrosmotic response to vasopressin through at least two distinct mechanisms: 1) it decreases prostaglandin synthesis and thus increases luminal permeability; 2) it decreases the resistance to water movement of the tissues beneath the luminal membrane.	Water	233-238	arginine vasopressin	Homo sapiens	64-75
3277539-9	1988	The PDH-stimulating activity eluted after bacitracin but ahead of ATP during gel filtration chromatography, and it was destroyed by exposure to NH4OH or alkaline phosphatase and by boiling in water.	Water	192-197	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	4-7
3126500-0	1988	Identification of specific apical membrane polypeptides associated with the antidiuretic hormone-elicited water permeability increase in the toad urinary bladder.	Water	106-111	arginine vasopressin	Homo sapiens	76-96
3126500-1	1988	Antidiuretic hormone (ADH) increases the water permeability of the toad urinary bladder.	Water	41-46	arginine vasopressin	Homo sapiens	0-26
3126500-4	1988	In response to ADH, the aggrephores fuse with the apical plasma membrane and render it water permeable.	Water	87-92	arginine vasopressin	Homo sapiens	15-18
3126500-5	1988	When ADH is removed, intramembrane particle aggregates and aggrephores are retrieved from the apical membrane, and it returns to a water-impermeable state.	Water	131-136	arginine vasopressin	Homo sapiens	5-8
3126500-15	1988	These polypeptides are evidently involved in the ADH-stimulated water permeability response and may be components of particle aggregates.	Water	64-69	arginine vasopressin	Homo sapiens	49-52
3287209-0	1988	Gamma-aminobutyric acid and taurine antagonize the central effects of angiotensin II and renin on the intake of water and salt, and on blood pressure in rats.	Water	112-117	angiotensinogen	Rattus norvegicus	70-84
3287209-2	1988	Angiotensin II (100 ng), injected into the preoptic area, stimulated the intake of water but not salt, to a lesser extent and with a shorter duration as compared with that induced by renin (5 mU), injected into the preoptic area.	Water	83-88	angiotensinogen	Rattus norvegicus	0-14
3287209-3	1988	This angiotensin II-induced intake of water was markedly inhibited by [Sar1, Ile8]-angiotensin II, an angiotensin II receptor antagonist, but not by captopril, an angiotensin-converting enzyme inhibitor, previously administered through the same cannula.	Water	38-43	angiotensinogen	Rattus norvegicus	5-19
3287209-3	1988	This angiotensin II-induced intake of water was markedly inhibited by [Sar1, Ile8]-angiotensin II, an angiotensin II receptor antagonist, but not by captopril, an angiotensin-converting enzyme inhibitor, previously administered through the same cannula.	Water	38-43	angiotensinogen	Rattus norvegicus	83-97
2980657-0	1988	[Plasma vasopressin changes in patients with renal failure during water immersion].	Water	66-71	arginine vasopressin	Homo sapiens	8-19
2964201-2	1988	When studied in vitro, ADH antagonists displace vasopressin from specific renal binding sites and antagonize, in a competitive fashion, vasopressin stimulation of adenylate cyclase and transepithelial water, salt, and urea fluxes.	Water	201-206	arginine vasopressin	Homo sapiens	23-26
2964201-2	1988	When studied in vitro, ADH antagonists displace vasopressin from specific renal binding sites and antagonize, in a competitive fashion, vasopressin stimulation of adenylate cyclase and transepithelial water, salt, and urea fluxes.	Water	201-206	arginine vasopressin	Homo sapiens	136-147
3278629-2	1988	Water deprivation produced marked increases in plasma renin activity and the concentration of AVP; however, plasma catecholamine concentrations were unchanged.	Water	0-5	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	54-59
3126665-1	1988	Angiotensin II (ANG II) is believed to stimulate sodium and water absorption from the small intestine by enhancing sympathetic nerve transmission.	Water	60-65	angiotensinogen	Rattus norvegicus	0-14
3126665-1	1988	Angiotensin II (ANG II) is believed to stimulate sodium and water absorption from the small intestine by enhancing sympathetic nerve transmission.	Water	60-65	angiotensinogen	Rattus norvegicus	16-22
3366051-4	1988	These results are compatible with a very early fall in brain water immediately on cessation of drinking (perhaps due to a rebound increase of vasopressin activity) with a return to "baseline" after two weeks.	Water	61-66	arginine vasopressin	Homo sapiens	142-153
3130264-7	1988	We conclude that changes in mineralocorticoid activity are the main factors contributing to the increase in renal sodium excretion seen during, and after, the continuous infusion of vasopressin in salt- and water-restricted man.	Water	207-212	arginine vasopressin	Homo sapiens	182-193
3340117-3	1988	We found that a water load suppressed plasma osmolality and vasopressin and urine osmolality in both groups, but that urinary dilution and free water clearance were impaired in the patients with hyponatremia, even though plasma levels of vasopressin and solute clearance were similar in the two groups.	Water	16-21	arginine vasopressin	Homo sapiens	60-71
3340117-3	1988	We found that a water load suppressed plasma osmolality and vasopressin and urine osmolality in both groups, but that urinary dilution and free water clearance were impaired in the patients with hyponatremia, even though plasma levels of vasopressin and solute clearance were similar in the two groups.	Water	16-21	arginine vasopressin	Homo sapiens	238-249
3340117-4	1988	Moreover, during water loading and infusion of hypertonic saline, the plasma level of vasopressin was higher at any given plasma osmolality in the test patients than in the controls, indicating a downward resetting of the osmostat.	Water	17-22	arginine vasopressin	Homo sapiens	86-97
2895431-11	1988	Deprivation of food and water, associated with analgesia possibly mediated by the opiate, beta-endorphin, which is not transported out of the brain by this system, did not alter transport.	Water	24-29	proopiomelanocortin	Homo sapiens	90-104
2451710-8	1988	The accumulation of water in the endoneurial compartment may be related to impaired extraction by the perineurium, to which the increased VIP content may contribute.	Water	20-25	vasoactive intestinal peptide	Rattus norvegicus	138-141
2827768-6	1988	These observations suggest that electrostatic binding of cytochrome c to the bilayer is accompanied by intramembrane penetration to such a depth that the protein can communicate with the inner membrane-water interface.	Water	202-207	cytochrome c, somatic	Homo sapiens	57-69
16665946-9	1988	Calculations of the amount of water potentially conserved by CAM-cycling yielded values of approximately 5 to 44% of daytime water loss.	Water	30-35	calmodulin 3	Homo sapiens	61-64
16665946-9	1988	Calculations of the amount of water potentially conserved by CAM-cycling yielded values of approximately 5 to 44% of daytime water loss.	Water	125-130	calmodulin 3	Homo sapiens	61-64
3422451-7	1988	The structure of the CPA-hydrated BBP complex provides support for a promoted-water hydrolytic mechanism, although it is not certain whether the enzyme has actually participated in the hydration reaction at the ketone carbonyl of BBP.	Water	78-83	carboxypeptidase A1	Homo sapiens	21-24
3124835-5	1988	The chromogenic substrate is the first phospholipid analog exhibiting absolute specificity for phospholipase A2 and should be applicable to spectrophotometric detection and kinetic characterization of both water soluble and membrane-bound forms.	Water	206-211	phospholipase A2 group IB	Homo sapiens	95-111
2855692-0	1988	Effect of water immersion on serum ACTH, cortisol and catecholamines in healthy individuals and diabetics.	Water	10-15	proopiomelanocortin	Homo sapiens	35-39
3349046-7	1988	Characterization of four Trp"s in alpha-lactalbumin shows that the two outer Trp"s are moderately H bonded to solvent water and closely surrounded by aliphatic side chains while the inner two are not H bonded nor closely surrounded by aliphatic side chains.	Water	118-123	lactalbumin alpha	Homo sapiens	34-51
2975142-3	1988	With these considerations in mind, we have attempted to elucidate the possible involvement of the central vasopressin (AVP) and atrial natriuretic factor (ANF) systems in the regulation of the water and ion homeostasis of the brain tissue of rats: Vasopressin-positive vascular connections, investigated by immuno-electronhistochemistry, were found in close or direct contact with brain microvessels.	Water	193-198	arginine vasopressin	Rattus norvegicus	106-117
3076739-0	1988	Effect of water immersion on plasma renin activity and aldosteronaemia in chronic renal failure.	Water	10-15	renin	Homo sapiens	36-41
3337271-10	1988	Furthermore, it demonstrates that ANG II is not merely permissive but probably the signal controlling water intake when arterial pressure is reduced below normal.	Water	102-107	angiotensinogen	Rattus norvegicus	34-40
3337547-1	1988	Water-induced activation of acetylcholinesterase.	Water	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-48
3337547-5	1988	In AP and polycythemia rubra vera after water exposure a significantly increased AChE activity suggesting acetylcholine release was observed, whereas in the patient with cold urticaria and the controls, a significant decrease was noted.	Water	40-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	81-85
3207390-2	1988	The present study was undertaken to examine early changes in vascular ultrastructure of rats receiving tap water supplemented with either calcium chloride or a relatively low dosage of irradiated ergocalciferol ad libitum for 21 days.	Water	107-112	nuclear RNA export factor 1	Rattus norvegicus	103-106
22893927-1	1988	Reactivation of 02 evolution function has been studied in PS-2 particles after complete removal of Mn and water soluble 10, 17, 24, 33 kDa proteins, It has been shown that 02 evolution function in such particles can be reactivated by adding 5 muM Mn2 and 20 mM Ca2(+).	Water	106-111	latexin	Homo sapiens	243-246
11537094-3	1988	We have now measured atrial natriuretic factor (ANF), a hormone recently shown to regulate sodium and water excretion, in blood specimens obtained during flight.	Water	102-107	natriuretic peptide A	Homo sapiens	21-46
11537094-3	1988	We have now measured atrial natriuretic factor (ANF), a hormone recently shown to regulate sodium and water excretion, in blood specimens obtained during flight.	Water	102-107	natriuretic peptide A	Homo sapiens	48-51
2975909-0	1988	Effects of antidiuretic hormone (AVP) and human atrial natriuretic peptide (hANP) on water and electrolyte balance in neonates.	Water	85-90	natriuretic peptide A	Homo sapiens	76-80
2977524-0	1988	Atrial natriuretic peptide (ANP)-induced increase in capillary albumin and water flux.	Water	75-80	natriuretic peptide A	Homo sapiens	0-26
2977524-0	1988	Atrial natriuretic peptide (ANP)-induced increase in capillary albumin and water flux.	Water	75-80	natriuretic peptide A	Homo sapiens	28-31
2447802-0	1988	Protein synthesis inhibitors attenuate water flow in vasopressin-stimulated toad urinary bladder.	Water	39-44	arginine vasopressin	Homo sapiens	53-64
2447802-1	1988	Vasopressin stimulates the introduction of aggregated particles, which may represent pathways for water flow, into the luminal membrane of toad urinary bladder.	Water	98-103	arginine vasopressin	Homo sapiens	0-11
2447802-11	1988	Puromycin (0.5 mM) also inhibited water flow by the fourth challenge with vasopressin.	Water	34-39	arginine vasopressin	Homo sapiens	74-85
3370116-1	1988	Ice water immersion as a form of self care.	Water	4-9	carboxylesterase 2	Homo sapiens	0-3
3250632-11	1988	The pore for water permeation might be induced in the border between phase-separated domains in PL.A2-treated liposomes.	Water	13-18	phospholipase A2 group IB	Homo sapiens	96-101
3077030-6	1988	The interaction of the renal medullary countercurrent system, circulating levels of antidiuretic hormone, and thirst regulates water metabolism.	Water	127-132	arginine vasopressin	Homo sapiens	84-104
3228647-2	1988	Both AII and Des-Asp1-AII increased water and 3% NaCl intake and increased urine and Na+ excretion, the effect of AII being more intense.	Water	36-41	angiotensinogen	Rattus norvegicus	5-8
3228647-2	1988	Both AII and Des-Asp1-AII increased water and 3% NaCl intake and increased urine and Na+ excretion, the effect of AII being more intense.	Water	36-41	angiotensinogen	Rattus norvegicus	22-25
3228647-2	1988	Both AII and Des-Asp1-AII increased water and 3% NaCl intake and increased urine and Na+ excretion, the effect of AII being more intense.	Water	36-41	angiotensinogen	Rattus norvegicus	22-25
2902974-2	1988	Vasopressin induces a rapid increase in water permeability and stimulates net sodium transport in responsive epithelia through the mediation of cAMP.	Water	40-45	arginine vasopressin	Homo sapiens	0-11
2902974-16	1988	Mucosal NEM appears to increase transcellular water flow by activating cellular processes normally triggered by vasopressin, at a step beyond cAMP.	Water	46-51	arginine vasopressin	Homo sapiens	112-123
2904322-8	1988	Dik-dik antelopes are very economical in their use of water, having a low daily water exchange and excreting a highly concentrated urine.	Water	54-59	receptor interacting serine/threonine kinase 4	Homo sapiens	0-3
2904322-8	1988	Dik-dik antelopes are very economical in their use of water, having a low daily water exchange and excreting a highly concentrated urine.	Water	54-59	receptor interacting serine/threonine kinase 4	Homo sapiens	4-7
2904322-8	1988	Dik-dik antelopes are very economical in their use of water, having a low daily water exchange and excreting a highly concentrated urine.	Water	80-85	receptor interacting serine/threonine kinase 4	Homo sapiens	0-3
2904322-8	1988	Dik-dik antelopes are very economical in their use of water, having a low daily water exchange and excreting a highly concentrated urine.	Water	80-85	receptor interacting serine/threonine kinase 4	Homo sapiens	4-7
3228647-0	1988	Effects of intracerebroventricular infusion of angiotensin II and related peptides on water and sodium ingestion and excretion.	Water	86-91	angiotensinogen	Rattus norvegicus	47-61
3417101-2	1988	Oral administration of the GABA transaminase inhibitor ethanolamine-O-sulphate (EOS, 5 mg/ml in drinking water) to rats for 14 days suppressed food intake by 24%, but reduced weight gain by over 35%.	Water	105-110	4-aminobutyrate aminotransferase	Rattus norvegicus	27-44
2853079-1	1988	Long term administration of thioacetamide (0.03% in tap water) results in a characteristic lesion in rat liver, which corresponds to cirrhosis-like patterns of micronodular cirrhosis type after treatment over 3 months.	Water	56-61	nuclear RNA export factor 1	Rattus norvegicus	52-55
3065564-0	1988	[Effect of immersion (WI) in mineral water on plasma renin activity (PRA) and aldosterone (ALD) and vasopressin (VP) levels in the blood of patients with arterial hypertension].	Water	37-42	renin	Homo sapiens	53-58
3281926-0	1988	Effects of water immersion on arginine vasopressin release in humans.	Water	11-16	arginine vasopressin	Homo sapiens	39-50
3281926-1	1988	Since suppression of arginine vasopressin (AVP) appears to be a determinant of the diuresis of water immersion (WI) in humans, a further understanding of its responsiveness has important implications for normal physiology, pathophysiology, and space physiology.	Water	95-100	arginine vasopressin	Homo sapiens	30-41
3281926-1	1988	Since suppression of arginine vasopressin (AVP) appears to be a determinant of the diuresis of water immersion (WI) in humans, a further understanding of its responsiveness has important implications for normal physiology, pathophysiology, and space physiology.	Water	95-100	arginine vasopressin	Homo sapiens	43-46
3281926-3	1988	In studies in which the subjects ingested water before or during WI, plasma AVP was reported to be unchanged or even increased.	Water	42-47	arginine vasopressin	Homo sapiens	76-79
3281926-5	1988	A critical review discloses that water intake before and/or during the experiments introduces several new stimuli for AVP release.	Water	33-38	arginine vasopressin	Homo sapiens	118-121
3062959-7	1988	Redistribution of intrarenal blood flow with increased medullary flow, in addition, will antagonize the hydrosmotic effect of vasopressin and thus result in a rise in free-water clearance.	Water	172-177	arginine vasopressin	Homo sapiens	126-137
2970167-0	1988	[Plasma ANP levels and its relation to electrolyte and water regulation in neurosurgical intensive care patients].	Water	55-60	natriuretic peptide A	Homo sapiens	8-11
2970181-2	1988	In the present study, the responsiveness of the ANF system to acute volume stimulation by water immersion and the diuretic and natriuretic effects of ANF infusion were examined.	Water	90-95	natriuretic peptide A	Homo sapiens	48-51
3279294-1	1988	Some critical level of calcium appears to be necessary for maximum expression of the hydroosmotic effect of vasopressin: both maneuvers which elevate cell calcium or activate calcium-dependent enzymes and maneuvers which diminish cell calcium or inhibit its effect diminish vasopressin-stimulated water flow.	Water	297-302	arginine vasopressin	Homo sapiens	108-119
3279294-2	1988	It would thus appear that cell calcium might well be maintained at some optimum level for mediating vasopressin-stimulated water flow across epithelia.	Water	123-128	arginine vasopressin	Homo sapiens	100-111
3279294-3	1988	At the same time, there is considerable evidence supporting vasopressin-elicited alterations in cell calcium and phospholipid metabolism; however, the linkage between these alterations and any eventual effects on water permeability has not yet been established with confidence.	Water	213-218	arginine vasopressin	Homo sapiens	60-71
2856643-5	1988	During 24 hr and 48 hr water deprivation vasopressin rose from 3.1 +/- 0.3 pg/ml to 7.3 +/- 1.3 pg/ml and 8.4 +/- 0.6 pg/ml (mean +/- SEM), respectively.	Water	23-28	arginine vasopressin	Rattus norvegicus	41-52
2962281-2	1987	These responses are documented by a new radioenzymatic assay to measure ANP in human plasma relative to hemodynamic measurements during diagnostic cardiac catheterization, atrial pressure changes during various types of pacemaker stimulation, and changes in cardiopulmonary volumes during head-out water immersion or upper leg cuff occlusion.	Water	298-303	natriuretic peptide A	Homo sapiens	72-75
2891378-6	1987	Both diastereomers of fluoroglutamate are decarboxylated by glutamate decarboxylase (EC 4.1.1.15) with fluoride release: KFG + H2O----CO2 + F- + HCOCH2CH2COOH.	Water	127-130	glutamate-ammonia ligase	Homo sapiens	60-83
2447967-8	1987	Recently, we have characterized the partition step, demonstrating that DHPs reside, on a time-average basis, near the bilayer hydrocarbon core/water interface.	Water	143-148	deoxyhypusine synthase	Homo sapiens	71-75
3329570-10	1987	Angiotensin II reduced delivery of water and solutes compared with captopril alone.	Water	35-40	angiotensinogen	Rattus norvegicus	0-14
3051651-4	1988	The renin-angiotensin-aldosterone system is very active, retaining Na+ with water.	Water	76-81	renin	Homo sapiens	4-9
3326859-3	1987	The maximal water diuresis method and the lithium clearance method both showed a negative correlation between plasma renin activity and distal sodium delivery and reabsorption.	Water	12-17	renin	Homo sapiens	117-122
3451799-0	1987	Regulation of angiotensin II binding sites in the subfornical organ and other rat brain nuclei after water deprivation.	Water	101-106	angiotensinogen	Rattus norvegicus	14-28
3451799-2	1987	Binding sites for angiotensin II have been localized in forebrain and brain-stem areas of water-deprived and control Sprague-Dawley rats, employing autoradiography with computerized microdensitometry.	Water	90-95	angiotensinogen	Rattus norvegicus	18-32
2450232-6	1987	Long-term enalapril prolonged survival (p = 0.014) with a median 50% survival of 164 (164-165) days, compared to 84 (64-104) days in rats receiving tap water.	Water	152-157	nuclear RNA export factor 1	Rattus norvegicus	148-151
3332245-3	1987	The magnocellular neurons of the hypothalamus produce the peptide anti-diuretic hormone (vasopressin) which acts on the kidney regulating water loss in the urine.	Water	138-143	arginine vasopressin	Homo sapiens	89-100
3319899-7	1987	for 2 weeks lowered tail-cuff pressure significantly (175 +/- 3 and 166 +/- 3 mm Hg, respectively; p less than 0.01) while rats drank tap water.	Water	138-143	nuclear RNA export factor 1	Rattus norvegicus	134-137
3328783-18	1987	injection of purified hog renin evoked water intake within about 1 min of injection, followed (about 6 h later) by increased salt intake.	Water	39-44	renin	Homo sapiens	26-31
2965232-3	1987	In this study we investigated a further possible interaction between ANP and angiotensin II (ANG II) in the control of renal water and electrolyte excretion.	Water	125-130	natriuretic peptide A	Homo sapiens	69-72
2965232-3	1987	In this study we investigated a further possible interaction between ANP and angiotensin II (ANG II) in the control of renal water and electrolyte excretion.	Water	125-130	angiotensinogen	Homo sapiens	77-91
2965232-3	1987	In this study we investigated a further possible interaction between ANP and angiotensin II (ANG II) in the control of renal water and electrolyte excretion.	Water	125-130	angiotensinogen	Homo sapiens	93-99
3317285-4	1987	Several hormones, notably aldosterone, ADH, PTH, and calcitonin, as well as vitamin D, are important in the regulation of water and solutes.	Water	122-127	parathyroid hormone	Homo sapiens	44-47
2961274-9	1987	The reduction in lithium and free water clearance under indomethacin tended to be reversed by ANP.	Water	34-39	natriuretic peptide A	Homo sapiens	94-97
2961274-11	1987	Indomethacin and ANP appear to have opposite effects on sodium excretion, maximal free water clearance, and lithium clearance.	Water	87-92	natriuretic peptide A	Homo sapiens	17-20
2965232-7	1987	These results suggest that ANP and ANG II interact within the kidney in the control of water and electrolyte excretion.	Water	87-92	natriuretic peptide A	Homo sapiens	27-30
2965232-7	1987	These results suggest that ANP and ANG II interact within the kidney in the control of water and electrolyte excretion.	Water	87-92	angiotensinogen	Homo sapiens	35-41
3120594-1	1987	The apical plasma membrane of toad bladder granular cells undergoes a rapid and dramatic increase in water permeability in response to vasopressin stimulation.	Water	101-106	arginine vasopressin	Homo sapiens	135-146
3688238-0	1987	Vasopressin effects on urea and H2O transport in inner medullary collecting duct subsegments.	Water	32-35	arginine vasopressin	Homo sapiens	0-11
3314457-5	1987	Fructose, 75 g/300 ml of water, elicited--in contrast to the same amount of glucose--only a small increase in insulin and glucose levels.	Water	25-30	insulin	Homo sapiens	110-117
3314489-7	1987	This lesion may represent the collecting tubule"s response to the intracellular accumulation of lithium, which interferes with cAMP formation and results in an early and probably reversible inhibition of antidiuretic hormone (ADH)-mediated water transport.	Water	240-245	arginine vasopressin	Homo sapiens	204-224
3314489-7	1987	This lesion may represent the collecting tubule"s response to the intracellular accumulation of lithium, which interferes with cAMP formation and results in an early and probably reversible inhibition of antidiuretic hormone (ADH)-mediated water transport.	Water	240-245	arginine vasopressin	Homo sapiens	226-229
2823714-15	1987	and H2O, or the prosthetic group to give rise to oxidative cleavage of the porphyrin ring structure of the heme moiety of LPO and thus to the liberation of iron.	Water	4-7	lactoperoxidase	Homo sapiens	122-125
3314489-11	1987	The action of amiloride on ADH-mediated water transport seems specific in as much as it is capable of preventing the uptake of lithium in high resistance epithelia and thereby prevents the inhibitory effect of intracellular lithium on water transport.	Water	40-45	arginine vasopressin	Homo sapiens	27-30
3314489-11	1987	The action of amiloride on ADH-mediated water transport seems specific in as much as it is capable of preventing the uptake of lithium in high resistance epithelia and thereby prevents the inhibitory effect of intracellular lithium on water transport.	Water	235-240	arginine vasopressin	Homo sapiens	27-30
3311989-6	1987	Serum vasopressin was higher in all groups of animals receiving hypertonic saline (1200 mosm/kg H2O; p less than 0.05), but the magnitude of increase was not significantly different in the SHR and WKY at either age.	Water	96-99	arginine vasopressin	Rattus norvegicus	6-17
3688238-8	1987	The results support the premise that (from the point of view of vasopressin effects on water and urea transport) there are two functionally distinct parts of the inner medullary collecting duct: an initial part that resembles the cortical or outer medullary portions of the mammalian collecting duct and a terminal part that resembles the toad urinary bladder.	Water	87-92	arginine vasopressin	Homo sapiens	64-75
3501848-5	1987	Reversed-phase high performance liquid chromatography of water extracts of the human ureter revealed the presence of neurokinin A- and eledoisin-like material using antiserum K12, which does not cross-react with substance P.	Water	57-62	tachykinin precursor 1	Homo sapiens	117-129
3323466-6	1987	The water solubility of both molecules, CF and insulin, was considerably increased with the addition of increasing concentrations of salicylate to the solutions: at 37 degrees C, 2.5 M sodium salicylate solution increases the CF solubility 532 times from 12.2 to 6.5 mg.mL-1, and 1.5 M salicylate increases the solubility of insulin 7875 times, thus an aqueous solution containing 630 mg.mL-1 of insulin may be prepared.	Water	4-9	insulin	Homo sapiens	47-54
3432461-5	1987	There was a fall of mean AVP excretion during mania, the magnitude of the fall being related to the increase of water throughput.	Water	112-117	arginine vasopressin	Homo sapiens	25-28
3308700-2	1987	Renin injected into the preoptic area increased water intake and evoked salt (2.7% NaCl solution) intake, and angiotensin II injected into this area increased water intake, but not salt intake, in both SHR and control normotensive Wistar-Kyoto rats (WKY).	Water	159-164	angiotensinogen	Rattus norvegicus	110-124
2820243-3	1987	All three EETs reversibly inhibited vasopressin-stimulated osmotic water flow with 5,6- and 11,12-EET being the most potent.	Water	67-72	arginine vasopressin	Homo sapiens	36-47
2820243-11	1987	Finally, 11,12- and 14,15-dihydroxyeicosatrienoic acid inhibited vasopressin- and forskolin-stimulated adenylate cyclase in the same rank order as their inhibition of water flow.	Water	167-172	arginine vasopressin	Homo sapiens	65-76
2820494-5	1987	In response to an 0.05 U/ml addition of thrombin, the rate of depolarization is 70-80% slower in 2H2O than in H2O.	Water	98-101	coagulation factor II, thrombin	Homo sapiens	40-48
2827872-4	1987	In response to water immersion, plasma ANP increased from a base-line level of 13.2 +/- 3.1 (mean +/- SEM) to 24.2 +/- 5.5 pg/mL by 0.5 h of immersion and was sustained at that level throughout the immersion period.	Water	15-20	natriuretic peptide A	Homo sapiens	39-42
2963166-5	1987	During hANP infusion, the filtration fraction increased slightly from 19.6 to 24.3% (P less than 0.001), fractional water excretion rose transiently at the beginning of the infusion.	Water	116-121	natriuretic peptide A	Homo sapiens	7-11
2963166-9	1987	Thus, under salt loading and water diuresis conditions, hANP infusion did not alter GFR, but reduced proximal reabsorption of sodium, and markedly enhanced the fraction of sodium escaping distal tubular reabsorption, suggesting that hANP-induced natriuresis is due, for an important part, to inhibition of sodium reabsorption in the distal nephron.	Water	29-34	natriuretic peptide A	Homo sapiens	56-60
2960378-3	1987	These findings are consistent with circular dichroism studies by other workers concluding that beta-endorphin is a random coil in water but that it forms 50% alpha-helix or more in mixed solvents.	Water	130-135	proopiomelanocortin	Homo sapiens	95-109
2960354-2	1987	One of the NSL, PCA, a pyrrolidinyl agent, was ionic and one, NAT, was a non-ionic pyrrolidinyl NSL with multiple hydroxyl substituents for water solubility.	Water	140-145	N-acetyltransferase 1	Rattus norvegicus	62-65
2443025-3	1987	Experiments also suggest significant bulk water flow from capillaries into brain within 10 min after opening at an average rate of approximately 1.6 X 10(-4) cm3 X s-1 X g brain-1.	Water	42-47	POU class 3 homeobox 3	Homo sapiens	172-179
2829704-11	1987	With the induction of renin-angiotensin system for increase in water intake, threshold rates for water intake and the threshold rates for raising blood pressure seem close.	Water	63-68	renin	Homo sapiens	22-27
2829704-11	1987	With the induction of renin-angiotensin system for increase in water intake, threshold rates for water intake and the threshold rates for raising blood pressure seem close.	Water	97-102	renin	Homo sapiens	22-27
3677548-2	1987	The inflammatory changes induced by CCl4 result in marked water absorption and moderate of fat.	Water	58-63	C-C motif chemokine ligand 4	Rattus norvegicus	36-40
3323466-6	1987	The water solubility of both molecules, CF and insulin, was considerably increased with the addition of increasing concentrations of salicylate to the solutions: at 37 degrees C, 2.5 M sodium salicylate solution increases the CF solubility 532 times from 12.2 to 6.5 mg.mL-1, and 1.5 M salicylate increases the solubility of insulin 7875 times, thus an aqueous solution containing 630 mg.mL-1 of insulin may be prepared.	Water	4-9	insulin	Homo sapiens	325-332
3323466-6	1987	The water solubility of both molecules, CF and insulin, was considerably increased with the addition of increasing concentrations of salicylate to the solutions: at 37 degrees C, 2.5 M sodium salicylate solution increases the CF solubility 532 times from 12.2 to 6.5 mg.mL-1, and 1.5 M salicylate increases the solubility of insulin 7875 times, thus an aqueous solution containing 630 mg.mL-1 of insulin may be prepared.	Water	4-9	insulin	Homo sapiens	325-332
3659605-3	1987	When they propelled themselves under water for 33 sec by kicking their legs and breathed through a snorkel tube, heart rate increased progressively to a value of 118 +/- 4.1 beats X min-1 at 28 sec.	Water	37-42	CD59 molecule (CD59 blood group)	Homo sapiens	182-187
2826736-5	1987	In saliva the most important part of this defense is salivary peroxidase, which detoxifies hydrogen peroxide in the presence of thiocyanate by converting it into hypothiocyanite, dioxygen and water.	Water	192-197	lactoperoxidase	Homo sapiens	53-72
3624414-0	1987	Cold water stimulation of oropharyngeal receptors in man inhibits release of vasopressin.	Water	5-10	arginine vasopressin	Homo sapiens	77-88
3663632-1	1987	In this paper we show that the action of phospholipase A2 can be triggered by applying an electric field across a 1,2-didodecanoyl-sn-3-phosphoglycerol monolayer residing between an alkylated silicon surface and water.	Water	212-217	phospholipase A2 group IB	Homo sapiens	41-57
2444253-1	1987	Solvent exchange of 18O-labeled buried water in bovine pancreatic trypsin inhibitor (BPTI), trypsin, and trypsin-BPTI complex is measured by high-precision isotope ratio mass spectrometry.	Water	39-44	trophoblast Kunitz domain protein 1	Bos taurus	66-83
3038998-9	1987	A particularly notable dissimilarity was evident when comparing the rate of their reversal: the TNF receptor level was fully recovered within a few hours of removal of IL-1 or of the water-soluble analogue of PMA, 4 beta-phorbol-12,13-dibutyrate, from pretreated SV-80 cells; yet at that time resistance to the cytotoxicity of TNF was still prominent.	Water	183-188	tumor necrosis factor	Homo sapiens	96-99
3114713-1	1987	Gossypol, a polyphenol compound with antifertility properties in human male, has been found to interfere with the response of toad bladder to vasopressin in terms of permeability to water and to urea; on the other hand, ion movement is spared for several hours as judged from short-circuit current and conductance data.	Water	182-187	arginine vasopressin	Homo sapiens	142-153
2825937-6	1987	The concurrent distribution of specific receptors for both peptides at these sites provides the basis for atrial natriuretic peptide to exert a functional antagonism of the actions of angiotensin II on blood pressure and water and electrolyte homeostasis at multiple sites.	Water	221-226	angiotensinogen	Rattus norvegicus	184-198
2887447-1	1987	The effects of tissue transglutaminase on the water-soluble proteins in bovine lens homogenates are described.	Water	46-51	transglutaminase 2	Homo sapiens	15-38
3658129-6	1987	By its presumed reduction of central and peripheral vasopressin release through lowering the cerebrospinal fluid sodium concentration, it may help in decreasing the brain water content.	Water	171-176	arginine vasopressin	Rattus norvegicus	52-63
3607066-7	1987	The effects of these various additives on the refolding behavior of serum albumin is interpreted in terms of subtle changes in the structure of water.	Water	144-149	albumin	Homo sapiens	68-81
3040254-4	1987	The increased volume of both principal and intercalated cells seems to be part of a general hyperplasia and hyperactivity of the collecting duct, which may in some way be related to the effects of lithium on vasopressin-mediated mediated water transport.	Water	238-243	arginine vasopressin	Rattus norvegicus	208-219
3121240-3	1987	Increased concentrations of antidiuretic hormone (ADH) result in retention of free water, increased excretion of sodium, and hyponatremia.	Water	83-88	arginine vasopressin	Homo sapiens	28-48
3121240-3	1987	Increased concentrations of antidiuretic hormone (ADH) result in retention of free water, increased excretion of sodium, and hyponatremia.	Water	83-88	arginine vasopressin	Homo sapiens	50-53
3654446-1	1987	Water immersion has long been known to produce marked diuresis, natriuresis, and kaliuresis and suppression of the renin-aldosterone system.	Water	0-5	renin	Homo sapiens	115-120
3498147-9	1987	The Ec50FSK for the forskolin-induced increase in vasopressin potency was 11 nmol, about two orders of magnitude lower than the Ec50FSK for the direct effect of forskolin on the osmotic water transport.	Water	186-191	arginine vasopressin	Homo sapiens	50-61
3037920-0	1987	Water permeability and particle aggregates in ADH-, cAMP-, and forskolin-treated toad bladder.	Water	0-5	arginine vasopressin	Homo sapiens	46-49
3452969-3	1987	The activity of GSHPx in brain microsomes was not changed after one year of vitamin E administration when it was measured against hydrogen hydroxide and against cumene hydrochloride; vitamin E administration increased the activity of GSH S-Tr in the cytoplasmic fraction of brain cells.	Water	130-148	glutathione peroxidase 1	Rattus norvegicus	16-21
2819935-5	1987	The D0 for inactivation of CAT expression by X irradiation of the plasmids in 1 mM Tris buffer was 270 Gy; it was 13 Gy for plasmids irradiated in water.	Water	147-152	catalase	Homo sapiens	27-30
2819935-6	1987	The D0"s for conversion of pSV2CAT to relaxed circle forms were only one-seventh as large as the D0"s for CAT inactivation after X-ray in water or in 1 mM Tris buffer.	Water	138-143	catalase	Homo sapiens	31-34
3037891-2	1987	Angiotensin II supported systemic BP by direct systemic vasoconstriction, by facilitating the central and peripheral effects of the sympathetic nervous system, by promoting renal sodium retention by the production of aldosterone, and by increasing total body water by enhancing thirst and the synthesis of vasopressin.	Water	259-264	angiotensinogen	Homo sapiens	0-14
3605388-0	1987	Inhibition of VP and OT release by water in hypovolemia is independent of opioid peptides.	Water	35-40	arginine vasopressin	Rattus norvegicus	14-16
3037920-0	1987	Water permeability and particle aggregates in ADH-, cAMP-, and forskolin-treated toad bladder.	Water	0-5	cathelicidin antimicrobial peptide	Homo sapiens	52-57
2956998-0	1987	Two-dimensional 1H-NMR investigation of the water conformation of the atrial natriuretic factor (ANF 101-126).	Water	44-49	natriuretic peptide A	Homo sapiens	97-100
3113444-3	1987	It was found that 48 but not 24 weeks of alcohol administration lead to a deficit as compared to pair-fed or tap-water controls.	Water	113-118	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	109-112
3039112-8	1987	The diuretic effects of full and partial kappa agonists correlated with plasma vasopressin levels in water-deprived rats.	Water	101-106	arginine vasopressin	Rattus norvegicus	79-90
3496207-6	1987	Treatment of LOBEX rats with 1-desamino-8-D-arginine vasopressin and oxytocin reduced water consumption and allowed for milk ejection and milk intake by the pups but did not restore the suckling-induced rise in PRL.	Water	86-91	arginine vasopressin	Rattus norvegicus	53-64
3034950-5	1987	In contrast, after the water load, vasopressin levels were undetectable (less than 2 pg/mL) and they increased only to 2.6 +/- 0.4 pg/mL with hypoglycemia.	Water	23-28	arginine vasopressin	Homo sapiens	35-46
2888098-0	1987	Influence of centrally administered somatostatin and two related peptides on intestinal absorption of water and electrolytes in conscious dogs.	Water	102-107	somatostatin	Canis lupus familiaris	36-48
3035942-1	1987	The effects of experimental procedures believed to increase cytosolic calcium on basal and vasopressin-stimulated osmotic water flow and transepithelial sodium transport were examined in the toad urinary bladder.	Water	122-127	arginine vasopressin	Homo sapiens	91-102
3658525-4	1987	In absolute terms, CRS was significantly greater (P less than 0.01) in full-term than in preterm NB (3.17 +/- 0.71 ml/cm H2O vs 2.37 +/- 0.81 ml/cm H2O).	Water	121-124	twist family bHLH transcription factor 1	Homo sapiens	19-22
3658525-4	1987	In absolute terms, CRS was significantly greater (P less than 0.01) in full-term than in preterm NB (3.17 +/- 0.71 ml/cm H2O vs 2.37 +/- 0.81 ml/cm H2O).	Water	148-151	twist family bHLH transcription factor 1	Homo sapiens	19-22
2954552-2	1987	NPY injection increased significantly IR-ANF while PYY decreased IR-ANF in the dose-response manner in normally-hydrated rats as well as in water-loaded rats.	Water	140-145	neuropeptide Y	Rattus norvegicus	0-3
3591984-5	1987	Water was allowed 15 min after cessation of the infusion, and within 5 min of drinking both plasma vasopressin and thirst were significantly lower than postinfusion.	Water	0-5	arginine vasopressin	Homo sapiens	99-110
2888098-4	1987	Similar reductions in the net fluxes of water, Na+ and K+ were observed over 2 to 5 hr following ICV administration of a putative somatostatin antagonist and SMS 201-995 at doses of 100 ng/kg.	Water	40-45	somatostatin	Canis lupus familiaris	130-142
2888098-7	1987	It is concluded that somatostatin and the two related peptides act centrally to reduce jejunal absorption of water and electrolytes.	Water	109-114	somatostatin	Canis lupus familiaris	21-33
2957643-7	1987	hANP, at 4.4 micrograms/h, caused a significant (p less than 0.001) 5-fold increase in the excretion of Na, Cl, and Ca, doubled the excretion rate of K and free water clearance, and significantly increased glomerular filtration rate.	Water	161-166	natriuretic peptide A	Homo sapiens	0-4
2440959-2	1987	Supplementation of culture medium with 1000 U/ml of IFN-gamma, but not 10 U/ml, inhibited the rate and overall metabolism of DMBA, and the formation of water-soluble DMBA conjugants.	Water	152-157	interferon gamma	Mus musculus	52-61
3334175-0	1987	[Modification of PRA, aldosterone, prolactin, and parathyroid hormone serum levels by "head-out" water immersion].	Water	97-102	S100 calcium binding protein A6	Homo sapiens	17-20
3611929-0	1987	Ham"s F-10 constituted with tap water supports mouse conceptus development in vitro.	Water	32-37	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	28-31
2956544-0	1987	[Studies of bathing water for tub baths].	Water	20-25	TUB bipartite transcription factor	Homo sapiens	30-33
3609132-2	1987	Animals were exposed to water immersion stress after a single injection of 2 nmol NPY.	Water	24-29	neuropeptide Y	Rattus norvegicus	82-85
3310425-0	1987	[Effect of water immersion on plasma renin activity, vasopressin and aldosterone level in diabetics].	Water	11-16	renin	Homo sapiens	37-42
2841939-1	1987	Carboxyl groups of NADPH-cytochrome P-450 reductase have been modified with the water-soluble carbodiimide EDC.	Water	80-85	cytochrome p450 oxidoreductase	Homo sapiens	19-51
2956106-2	1987	Water immersion to the neck for 2 h caused a brisk diuresis, natriuresis and raised plasma ANP in 8 healthy subjects, suggesting that ANP is a mediator of diuresis and natriuresis during immersion.	Water	0-5	natriuretic peptide A	Homo sapiens	91-94
2956106-2	1987	Water immersion to the neck for 2 h caused a brisk diuresis, natriuresis and raised plasma ANP in 8 healthy subjects, suggesting that ANP is a mediator of diuresis and natriuresis during immersion.	Water	0-5	natriuretic peptide A	Homo sapiens	134-137
3033217-9	1987	Although these results suggest that the intact hormone is required for the maximal effect of PTH on water flow, substantial activity resides in the amino terminal fragment of the hormone.	Water	100-105	parathyroid hormone	Homo sapiens	93-96
3038556-2	1987	Volume loading, vasoconstrictor agents, immersion in water, atrial tachycardia and high salt diets have been reported to increase the release of cardiac ANP, thereby suggesting that the peptide is released in response to an increase in atrial pressure.	Water	53-58	natriuretic peptide A	Homo sapiens	153-156
3033217-3	1987	As reported previously by us, PTH (1-84) significantly stimulated basal water flow in isolated toad bladder sacs.	Water	72-77	parathyroid hormone	Homo sapiens	30-33
3033217-5	1987	Intact PTH (1-84) and synthetic 1-34 PTH significantly inhibited both arginine-vasopressin and cyclic AMP-stimulated water flow.	Water	117-122	parathyroid hormone	Homo sapiens	7-10
2886584-10	1987	However, this dose of morphine did cause a 63.5% decrease in the VIP-induced change in water transport.	Water	87-92	vasoactive intestinal peptide	Rattus norvegicus	65-68
3033217-5	1987	Intact PTH (1-84) and synthetic 1-34 PTH significantly inhibited both arginine-vasopressin and cyclic AMP-stimulated water flow.	Water	117-122	parathyroid hormone	Homo sapiens	37-40
3033217-11	1987	Alterations in Ca transport appear to mediate the effect of PTH on water flow.	Water	67-72	parathyroid hormone	Homo sapiens	60-63
3621755-0	1987	[Evaluation of secretory patterns of antidiuretic hormone in patients with myotonic dystrophy by a water-loading test].	Water	99-104	arginine vasopressin	Homo sapiens	37-57
3110736-1	1987	I. Preservation of vasopressin-stimulated water and urea pathways in rat papillary collecting duct.	Water	42-47	arginine vasopressin	Rattus norvegicus	19-30
3110736-3	1987	Arginine vasopressin (AVP) at 10(-9) mol/l increased diffusional water permeability (Pdw) from 101.9 +/- 10.76 to 283.3 +/- 16.67 X 10(-7) cm2 s-1 (n = 8, P less than 0.01) and urea permeability (Purea) from 30.3 +/- 2.24 to 83.5 +/- 7.80 X 10(-7) cm2 s-1 (n = 8, P less than 0.01).	Water	65-70	arginine vasopressin	Rattus norvegicus	0-20
3110736-3	1987	Arginine vasopressin (AVP) at 10(-9) mol/l increased diffusional water permeability (Pdw) from 101.9 +/- 10.76 to 283.3 +/- 16.67 X 10(-7) cm2 s-1 (n = 8, P less than 0.01) and urea permeability (Purea) from 30.3 +/- 2.24 to 83.5 +/- 7.80 X 10(-7) cm2 s-1 (n = 8, P less than 0.01).	Water	65-70	arginine vasopressin	Rattus norvegicus	22-25
3579903-1	1987	Water-soluble apolipoprotein B was prepared from fresh plasma by quick isolation of low density lipoproteins and immediate delipidization under non-oxidative conditions.	Water	0-5	apolipoprotein B	Homo sapiens	14-30
3551628-4	1987	This increase in vasopressin was not due to a loss of osmoregulation, because changes in plasma osmolality and sodium, induced by infusion of hypertonic saline or water loading, induced appropriate vasopressin responses under insulin deplete as well as replete conditions.	Water	163-168	arginine vasopressin	Homo sapiens	17-28
3593881-6	1987	This rigid and highly hydrated structure (4 g water/g protein) accommodates the latest nodular models obtained from electron microscopy, explains the singular hydrodynamics of fibrinogen and, apparently, it would perform the two main functions of the protein in haemostasis, blood coagulation and platelet aggregation, more efficiently than the flexible molecule.	Water	46-51	fibrinogen beta chain	Homo sapiens	176-186
3656163-14	1987	There were significant increases in plasma angiotensin II and aldosterone levels at the end of the water deprivation periods in both strains of rat, and after the drinking water was returned there was a marked anti-natriuresis consistent with an expression of one of the renal actions of aldosterone.	Water	99-104	angiotensinogen	Rattus norvegicus	43-57
3299003-1	1987	In bacterial cells near-ultraviolet radiation (NUV) generates H2O2 which can be decomposed by endogenous catalase to H2O and O2.	Water	62-65	catalase	Homo sapiens	105-113
3564840-8	1987	The osmoregulation disturbance of the AVP secretion may play a major role in the impaired water metabolism in primary hypothyroidism and in Addison"s disease.	Water	90-95	arginine vasopressin	Homo sapiens	38-41
3494249-3	1987	The predicted configuration of the MAL protein resembles the structure of integral proteins that form pores or channels in the plasma membrane and that are believed to act as transporters of water-soluble molecules and ions across the lipid bilayer.	Water	191-196	mal, T cell differentiation protein	Homo sapiens	35-38
3035468-7	1987	Renal effects of angiotensin II and aldosterone are responsible for sodium and water retention.	Water	79-84	angiotensinogen	Homo sapiens	17-31
3492963-8	1987	Exposure of A-1-PI and BLPI in the presence of the antioxidants, Trolox C (water soluble vitamin E) and ascorbic acid (vitamin C), showed that antioxidant vitamins may protect proteins from oxidative inactivation by ozone.	Water	75-80	secretory leukocyte peptidase inhibitor	Homo sapiens	23-27
3826420-1	1987	Neuropeptide Y (NPY) is a potent stimulator of food and water intake in rats.	Water	56-61	neuropeptide Y	Rattus norvegicus	0-14
3826420-1	1987	Neuropeptide Y (NPY) is a potent stimulator of food and water intake in rats.	Water	56-61	neuropeptide Y	Rattus norvegicus	16-19
2950133-1	1987	Although maneuvers augmenting atrial volume and/or stretch also augment plasma levels of atrial natriuretic factor (ANF), the role of ANF in modulating renal sodium and water handling has not been defined.	Water	169-174	natriuretic peptide A	Homo sapiens	134-137
2950133-2	1987	Water immersion to the neck (NI) was employed to assess the ANF response to acute volume expansion in 13 seated sodium-replete normal subjects.	Water	0-5	natriuretic peptide A	Homo sapiens	60-63
3566286-1	1987	The aim of the work was to elucidate the role of water in the reaction between acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) and methanesulfonyl fluoride, accelerated by accelerators.	Water	49-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-99
3566286-6	1987	These findings, together with others, led to the following model of the role of hydration water in acylation of acetylcholinesterase.	Water	90-95	acetylcholinesterase (Cartwright blood group)	Homo sapiens	112-132
2892671-2	1987	In addition to promoting diuresis and natriuresis, ANF has been shown to produce vascular smooth muscle relaxation and to inhibit the secretion of aldosterone from the adrenal cortex, renin from the juxtaglomerlular apparatus, vasopressin from the hypothalamus, and salt and water intake after central administration.	Water	275-280	natriuretic peptide A	Homo sapiens	51-54
2962860-4	1987	Additionally, ANF and ANF receptors are present in the central and peripheral nervous system, and ANF administered in the brain exerts striking effects relating to vasopressin and water consumption.	Water	180-185	natriuretic peptide A	Homo sapiens	22-25
2962860-4	1987	Additionally, ANF and ANF receptors are present in the central and peripheral nervous system, and ANF administered in the brain exerts striking effects relating to vasopressin and water consumption.	Water	180-185	natriuretic peptide A	Homo sapiens	22-25
2885243-0	1987	Water and sodium transport: effects of calcium channel blocker and calmodulin antagonists on the apical and basolateral membranes of amphibian epithelia.	Water	0-5	calmodulin 1	Homo sapiens	67-77
3808063-4	1987	In our experiments, we were able to measure the air-water distribution coefficients of pesticides between the liquid fog and the interstitial gas phase.	Water	52-57	zinc finger protein, FOG family member 1	Homo sapiens	117-120
3494488-3	1987	Additional studies showed that the dipsogenic response to angiotensin II (200 micrograms/kg, SC) decreased as the concentration of NaCl solution offered to drink increased beyond 0.15 M in rats given either water or NaCl solution to drink.	Water	207-212	angiotensinogen	Rattus norvegicus	58-72
3494488-5	1987	When the rats were allowed to choose between either 0.15 or 0.25 M NaCl solution and water, administration of angiotensin II (either 100 or 200 micrograms/kg, SC) increased water intake in preference to the NaCl solution.	Water	85-90	angiotensinogen	Rattus norvegicus	110-124
3494488-5	1987	When the rats were allowed to choose between either 0.15 or 0.25 M NaCl solution and water, administration of angiotensin II (either 100 or 200 micrograms/kg, SC) increased water intake in preference to the NaCl solution.	Water	173-178	angiotensinogen	Rattus norvegicus	110-124
2885243-3	1987	The same concentrations of these blockers when applied to the mucosal side of frog urinary bladder selectively decreased vasopressin stimulated water permeability and did not influence ionic permeability.	Water	144-149	arginine vasopressin	Homo sapiens	121-132
3545878-3	1987	After exposure to 8.5 Gy, all mice drank tap water.	Water	45-50	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	41-44
2885243-5	1987	The results show that the Ca2+ channel blocker and the calmodulin antagonists tested influenced water and ionic transport across the epithelial cell membranes, and had different effects upon the apical and the basolateral cell membranes.	Water	96-101	calmodulin 1	Homo sapiens	55-65
3575362-0	1987	Effect of acute administration of bromocriptine on isoproterenol- and angiotensin II-induced water intake in estrogen-treated rats.	Water	93-98	angiotensinogen	Rattus norvegicus	70-84
3555207-3	1987	Clinical consequences of these neurohumoral changes are: excessive increase of aortic impedance and myocardial work, salt and water retention a processus which is angiotensin II-dependent, and eventually, hyponatremia.	Water	126-131	angiotensinogen	Homo sapiens	163-177
3101519-1	1987	We recently demonstrated that parathyroid hormone (PTH) inhibited both vasopressin- and cyclic AMP-stimulated water transport in the toad bladder.	Water	110-115	parathyroid hormone	Homo sapiens	30-49
3101519-1	1987	We recently demonstrated that parathyroid hormone (PTH) inhibited both vasopressin- and cyclic AMP-stimulated water transport in the toad bladder.	Water	110-115	parathyroid hormone	Homo sapiens	51-54
3101519-1	1987	We recently demonstrated that parathyroid hormone (PTH) inhibited both vasopressin- and cyclic AMP-stimulated water transport in the toad bladder.	Water	110-115	arginine vasopressin	Homo sapiens	71-82
3101519-3	1987	We postulated that PTH exerts its action on H2O transport by directly stimulating calcium uptake.	Water	44-47	parathyroid hormone	Homo sapiens	19-22
3101519-5	1987	In toad bladder, PTH and A23187 decreased arginine vasopressin (AVP)-stimulated H2O flow and short-circuit current (SCC) after 60 min serosal incubation.	Water	80-83	parathyroid hormone	Homo sapiens	17-20
3101519-5	1987	In toad bladder, PTH and A23187 decreased arginine vasopressin (AVP)-stimulated H2O flow and short-circuit current (SCC) after 60 min serosal incubation.	Water	80-83	arginine vasopressin	Homo sapiens	51-62
3324681-2	1987	Prolactin may be important in the regulation of water and ion transport across the amnion, the production of surfactant by the fetal lung, and the immune response during pregnancy.	Water	48-53	prolactin	Homo sapiens	0-9
3492924-8	1987	Taking a value of 0.35 for the solvent drag reflection coefficient for alpha-lactalbumin, we conclude that the increased solute flux represents solvent drag through a water pathway with a hydraulic conductivity of 3.6 X 10(-7) cm X s-1 X cmH2O-1.	Water	167-172	lactalbumin alpha	Homo sapiens	71-88
3492924-9	1987	Our data conforms to the hypothesis that alpha-lactalbumin is transported across the capillary wall by restricted diffusion and solvent drag in a pathway that carries 90% of the transcapillary water flow (the principle water pathway).	Water	193-198	lactalbumin alpha	Homo sapiens	41-58
3492924-9	1987	Our data conforms to the hypothesis that alpha-lactalbumin is transported across the capillary wall by restricted diffusion and solvent drag in a pathway that carries 90% of the transcapillary water flow (the principle water pathway).	Water	219-224	lactalbumin alpha	Homo sapiens	41-58
3663070-0	1987	[Forensic significance of electric metallization of bathing water in deaths caused by electric current in the bath-tub].	Water	60-65	TUB bipartite transcription factor	Homo sapiens	115-118
2954520-0	1987	[Atrial natriuretic factor (morphology and various physiologic characteristics of a new system of regulating water-salt homeostasis].	Water	109-114	natriuretic peptide A	Homo sapiens	1-26
3451786-2	1987	The injection of a hypertonic saline solution (0.2 M NaCl) into the lateral preoptic area of the rat produced an increase in water intake that was further increased by the injection of angiotensin II (4 ng) into the subfornical organ.	Water	125-130	angiotensinogen	Rattus norvegicus	185-199
3801648-3	1987	Water-soluble enzyme conjugates devoid of fibrinogen-coagulating action and possessing increased fibrinolytic affinity to the site of fibrin clot location have been obtained by covalent binding of chymotrypsin to modified thrombin.	Water	0-5	coagulation factor II, thrombin	Homo sapiens	222-230
3580425-7	1987	Fetal plasma AVP levels decreased 17 +/- 6% by 30 min following the completion of water loading (1.7 +/- 0.07 to 1.4 +/- 0.16 microU/ml; p less than 0.05).	Water	82-87	arginine vasopressin	Homo sapiens	13-16
3580425-9	1987	These results indicate that maternal and fetal plasma AVP levels correlate under basal conditions and that maternal water loading, which significantly decreases fetal plasma osmolality, significantly suppresses fetal plasma AVP concentrations.	Water	116-121	arginine vasopressin	Homo sapiens	224-227
3451786-9	1987	Intravenous perfusion of angiotensin II (40 ng microliters-1 min-1) caused increased water intake, arterial pressure and heart rate.	Water	85-90	angiotensinogen	Rattus norvegicus	25-39
3451786-12	1987	Intravenous perfusion with 0.5 M NaCl caused an increase in water intake which was further increased after the injection of angiotensin II (4 ng) into the subfornical organ and angiotensin II (4 ng) into the lateral preoptic area.	Water	60-65	angiotensinogen	Rattus norvegicus	124-138
3451786-12	1987	Intravenous perfusion with 0.5 M NaCl caused an increase in water intake which was further increased after the injection of angiotensin II (4 ng) into the subfornical organ and angiotensin II (4 ng) into the lateral preoptic area.	Water	60-65	angiotensinogen	Rattus norvegicus	177-191
3802396-12	1987	Only small amounts of the water-soluble metabolites from these cell cultures eluted in the same volumes as the synthetic GSH conjugate of BP-4,5-oxide, BP-7,8-oxide and BP-7,8-diol-9,10-oxide.	Water	26-31	BP4	Homo sapiens	138-142
2886269-8	1987	Female trout exposed to calcium-enriched freshwater had increased plasma vitellogenin levels compared to females in soft water, whereas there was a tendency for low pH to decrease plasma vitellogenin in these fish.	Water	46-51	LOC100136735	Oncorhynchus mykiss	73-85
3447938-0	1987	The role of arginine-vasopressin in the regulation of water metabolism in preterm infants in the first days of life.	Water	54-59	arginine vasopressin	Homo sapiens	12-32
2881643-3	1987	As the internal Na concentration was raised from 5 mmol/kg muscle water to 18 mmol/kg muscle water, the magnitude of the insulin-induced increase in the ouabain-sensitive Na efflux (an index of the Na,K-pump activity) rose by 5-fold and the magnitude of the insulin-induced hyperpolarization rose by 8.5-fold.	Water	93-98	insulin	Homo sapiens	121-128
3666400-7	1987	After oral or intraduodenal administration of 3 g/kg of HO1 or HO2, gastric juice secretion and ulcers induced by water immersion stress, histamine and reserpine in rats were inhibited.	Water	114-119	heme oxygenase 2	Rattus norvegicus	63-66
2881643-3	1987	As the internal Na concentration was raised from 5 mmol/kg muscle water to 18 mmol/kg muscle water, the magnitude of the insulin-induced increase in the ouabain-sensitive Na efflux (an index of the Na,K-pump activity) rose by 5-fold and the magnitude of the insulin-induced hyperpolarization rose by 8.5-fold.	Water	66-71	insulin	Homo sapiens	121-128
3782433-5	1987	Both patients had increased renal sensitivity to vasopressin, achieving negative free water clearance at infusion rates of 0.4 and 4 fmol/kg X min (normal greater than or equal to 6).	Water	86-91	arginine vasopressin	Homo sapiens	49-60
3100473-5	1987	Two weeks after the onset of diabetes, increased immunohistochemical staining for aldose reductase appears beneath the epithelial region where water cleft formation occurs, and the intensity of this staining increases with the formation of vacuoles.	Water	143-148	aldo-keto reductase family 1 member B	Homo sapiens	82-98
3108510-4	1987	Physiological studies show that oxytocin, a synthetic analog of antidiuretic hormone, is still capable of inducing increases in water transport in epithelia which were osmotically reversed.	Water	128-133	arginine vasopressin	Homo sapiens	64-84
2955160-4	1987	Stimulation of the ANF-system by head-out water immersion, however, revealed an impaired increase in ANF release in cirrhotic patients with ascites (146 +/- 18% vs 204 +/- 16%).	Water	42-47	natriuretic peptide A	Homo sapiens	19-22
2955161-3	1987	Moreover the role of alpha-hANP is of particular interest in chronic renal failure, since in this pathological condition increased sodium and water retention plays a major pathogenetic role in the development of hypertension and altered secretion and/or metabolism of alpha-hANP may contribute to fluid volume and BP regulation.	Water	142-147	natriuretic peptide A	Homo sapiens	27-31
2955165-1	1987	Administration of atrial natriuretic peptides (ANP) is followed by an immediate increase in the urinary excretion of NaCl and water.	Water	126-131	natriuretic peptide A	Homo sapiens	47-50
2896279-0	1987	Adrenergic transmission and the neurohypophyseal hormones under different conditions of water metabolism.	Water	88-93	arginine vasopressin	Homo sapiens	32-48
2884582-5	1987	Significant increases of ANF as well as of cGMP have been discovered in heart and renal failure, secondary hypertension and other states with altered salt-water balance, impairment of heart function and particularly increase of atrial pressure.	Water	155-160	natriuretic peptide A	Homo sapiens	25-28
3039435-1	1987	Prolactin has been known to affect the water and electrolyte balance.	Water	39-44	prolactin	Rattus norvegicus	0-9
2442780-0	1987	Mechanisms for the inhibition of vasopressin-stimulated water flow by captopril in the toad bladder.	Water	56-61	arginine vasopressin	Homo sapiens	33-44
2442780-1	1987	The mechanisms by which captopril inhibits vasopressin-stimulated osmotic water flow in the toad bladder have been investigated in vitro.	Water	74-79	arginine vasopressin	Homo sapiens	43-54
2442780-2	1987	Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin E2 (PGE2) biosynthesis by inhibition of kininase II activity, the other, is a direct effect on water flow independent of PGE2.	Water	71-76	angiotensin I converting enzyme	Homo sapiens	170-181
2442780-3	1987	Captopril inhibited the vasopressin-, cyclic adenosine monophosphate- and 3-isobutyl-1-methyl-xanthine-stimulated water flow.	Water	114-119	arginine vasopressin	Homo sapiens	24-35
2442780-4	1987	The inhibition of water flow by bradykinin was enhanced by captopril.	Water	18-23	kininogen 1	Homo sapiens	32-42
2442780-7	1987	Thus, it was concluded that captopril inhibits the vasopressin-stimulated water flow indirectly by inhibiting the degradation of bradykinin and thereby enhancing the production of PGE2, and directly at a site following the production of cyclic adenosine monophosphate by vasopressin.	Water	74-79	arginine vasopressin	Homo sapiens	51-62
3667112-3	1987	By contrast, white wine or water +10% ethanol significantly increased acid secretion, with a tendency to elevate plasma gastrin concentrations.	Water	27-32	gastrin	Canis lupus familiaris	120-127
3029357-4	1987	With the aid of a relocation pin attached to the nozzle of the instrument it was demonstrated that nozzle-target distance, the air pressure input, the flow of water and the time of operation were all factors which affected the clinical efficiency of the instrument.	Water	159-164	dynein light chain LC8-type 1	Homo sapiens	29-32
2955141-1	1987	The physiological mechanism regulating secretion of human atrial natriuretic polypeptide (hANP) was examined by measuring plasma hANP by a specific radioimmunoassay during head-out total body water immersion (WI) and saline infusion in normal men.	Water	192-197	natriuretic peptide A	Homo sapiens	90-94
2955141-8	1987	Moreover, the peak hANP level was significantly smaller during either condition of saline infusion than during water immersion.	Water	111-116	natriuretic peptide A	Homo sapiens	19-23
3695930-4	1987	For 7 months the rats were intragastrically administered, with a tube, 20% water solutions of TOX and DOX at 1/10, 1/40 and 1/80 DL50 doses; in addition, for 4 months they were given 100% DOX at 1/10 DL50 doses; Within the experiment, the animals" mortality, appearance and behaviour were observed and once a month their body weight was determined.	Water	75-80	thymocyte selection-associated high mobility group box	Rattus norvegicus	94-97
2880308-2	1987	Administration of somatostatin (0.5-1.5 microgram in 1.0 microliter) into the lateral hypothalamus, but not the ventromedial or the anterior hypothalamus, caused a reduction in food consumption without affecting relative water intake (or water-to-food ratio) in conscious rats in a freely moving state.	Water	238-243	somatostatin	Rattus norvegicus	18-30
3628548-4	1987	III-ICV administration of angiotensin II (100 ng/rat) to rats provided with ad lib food and water elicited short latency drinking without affecting food intake.	Water	92-97	angiotensinogen	Rattus norvegicus	26-40
2947474-9	1986	The data dissociate in uninephrectomized primate the effects of ANF on water and solute excretion from those on GFR and filtration fraction.	Water	71-76	natriuretic peptide A	Homo sapiens	64-67
3575881-3	1987	Male Wistar rats (n = 192) were divided into eight groups and they were fed either a mixture of water and 15% (v/v) ethanol or tap water combined with standard or special diets for 12 weeks.	Water	131-136	nuclear RNA export factor 1	Rattus norvegicus	127-130
3327185-3	1987	Pathophysiological features of arterial hypertension in nephritides are the following: disturbances of physiological interrelationships between renin plasma activity and the state of water-electrolyte balance; hyperaldosteronism and depression of renal prostaglandin synthesis revealed both in unchanged and lowered renal function.	Water	183-188	renin	Homo sapiens	144-149
3025536-0	1986	Enhancing effects of angiotensin I on the vasopressin-stimulated water flow of toad bladder through increased cyclic AMP in mucosal cells.	Water	65-70	angiotensinogen	Homo sapiens	21-34
3025536-0	1986	Enhancing effects of angiotensin I on the vasopressin-stimulated water flow of toad bladder through increased cyclic AMP in mucosal cells.	Water	65-70	arginine vasopressin	Homo sapiens	42-53
3025536-1	1986	The effects of angiotensins I and II on 10 mU/ml vasopressin-stimulated water flow across toad bladder were examined.	Water	72-77	arginine vasopressin	Homo sapiens	49-60
3025536-2	1986	Angiotensin I at concentrations of 10(-6) and 10(-7) M enhanced the water flow, but angiotensin II failed to do so at these concentrations.	Water	68-73	angiotensinogen	Homo sapiens	0-13
3025536-6	1986	These results indicate that angiotensin I enhances vasopressin-stimulated water flow by increasing cyclic AMP production in bladder cells and that angiotensin II may possibly interfere with angiotensin I in a competitive manner.	Water	74-79	angiotensinogen	Homo sapiens	28-41
3025536-6	1986	These results indicate that angiotensin I enhances vasopressin-stimulated water flow by increasing cyclic AMP production in bladder cells and that angiotensin II may possibly interfere with angiotensin I in a competitive manner.	Water	74-79	arginine vasopressin	Homo sapiens	51-62
20568215-2	1986	Small-angle neutron scattering (SANS) studies have shown that insertion of the protein cytochrome-c in the reversed micelle polar core causes a significant reapportioning of the surfactants and water between the filled and unfilled micelles, leading to an increase in overall size of the filled micelles relative to their empty counterparts.	Water	194-199	cytochrome c, somatic	Homo sapiens	87-99
3536587-2	1986	Recent studies, however, have demonstrated that in several forms of chronic hypertension caused by aldosterone, angiotensin II (AngII), vasopressin, or norepinephrine and adrenocorticotropin, increased renal arterial pressure is essential for maintaining normal excretion of sodium and water in the face of reduced renal excretory capability.	Water	286-291	angiotensinogen	Homo sapiens	128-133
3562899-3	1986	In radioimmunoassay, boiling water extracts of the neural ganglion reacted with C-terminal specific gastrin/CCK antibodies, but not N-terminal or intact G17 specific antibodies.	Water	29-34	cholecystokinin	Homo sapiens	108-111
3033178-2	1986	This rise in delta P was prevented by therapy with the angiotensin I converting enzyme inhibitor enalapril (15 mg/l drinking water, group DM + E) even though glomerular hyperperfusion and hyperfiltration persisted.	Water	125-130	angiotensin I converting enzyme	Rattus norvegicus	55-86
2945832-4	1986	In NL, ANF infusion of 0.10 microgram/kg per min (40 pmol/kg per min) induced increases (P less than 0.05) of absolute (from 160 +/- 23 to 725 +/- 198 mueq/min) and fractional (1-4%) sodium excretion, urine flow rate (from 10 +/- 1.6 to 20 +/- 2.6 ml/min), osmolar (from 3.2 +/- 0.6 to 6.8 +/- 1.2 ml/min) and free water (from 6.8 +/- 1.6 to 13.6 +/- 1.6 ml/min) clearances, and filtration fraction (from 20 +/- 1 to 26 +/- 2%).	Water	315-320	natriuretic peptide A	Homo sapiens	7-10
3829449-2	1986	Ethanol (4-5% v/v in drinking water for 42 days) significantly increased the concentration of PRL, and tended to decrease that of LH.	Water	30-35	prolactin	Meleagris gallopavo	94-97
3020993-1	1986	Following intravenous infusion, angiotensin I (ANG I), angiotensin II (ANG II), and angiotensin III (ANG III) enhance Na and water absorption across the jejunum by increasing sympathetic nerve activity.	Water	125-130	angiotensinogen	Rattus norvegicus	55-69
2951661-7	1986	Seventy-two hr water deprivation (mixed osmotic and volume stimulus) resulted in elevated plasma AVP levels which were unaffected by an IV bolus injection of ANF at doses of 0.06-10 micrograms.	Water	15-20	arginine vasopressin	Rattus norvegicus	97-100
3020993-1	1986	Following intravenous infusion, angiotensin I (ANG I), angiotensin II (ANG II), and angiotensin III (ANG III) enhance Na and water absorption across the jejunum by increasing sympathetic nerve activity.	Water	125-130	angiotensinogen	Rattus norvegicus	71-77
3830070-8	1986	The administration of AVP to aged rats resulted in a significant decrease in water intake and urinary volume, but AVP administration did not induce any change in the electrolyte balance.	Water	77-82	arginine vasopressin	Rattus norvegicus	22-25
3769519-1	1986	Because cholecystokinin octapeptide and angiotensin II are directly involved in intestinal food and water absorption, the effect of these two compounds on intestinal motor responses of hibernating and alert 13-lined ground squirrels was investigated.	Water	100-105	angiotensinogen	Homo sapiens	40-54
3830070-9	1986	Therefore, it is concluded that the main cause of the development of polydipsia and polyuria is the decline in renal function but not in neurosecretory activity, although exogenous AVP can effectively reduce water intake and urinary output in aged rats.	Water	208-213	arginine vasopressin	Rattus norvegicus	181-184
3795625-3	1986	In the 48- and 72-hr water-deprived rats, contents of cytochrome p-450 and activities of aminopyrine N-demethylase were significantly decreased.	Water	21-26	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	54-70
3758300-1	1986	Chronic daily intake of 0.5% H2O2 in drinking water decreased Se-dependent glutathione peroxidase (Se-GSHPx) activity in rat skeletal muscle, kidney and liver.	Water	46-51	glutathione peroxidase 1	Rattus norvegicus	102-107
3758300-3	1986	Deprivation of drinking water decreased Se-GSHPx activity in kidney and non-Se GSHPx activity in kidney and liver.	Water	24-29	glutathione peroxidase 1	Rattus norvegicus	43-48
3752258-0	1986	Effect of vasopressin on ependymal and capillary permeability to tritiated water in cat.	Water	75-80	arginine vasopressin	Homo sapiens	10-21
3092675-8	1986	However, immunoassay of granule antigen after vasopressin stimulation of water permeability failed to show a detectable change in granule exocytosis.	Water	73-78	arginine vasopressin	Homo sapiens	46-57
3752258-9	1986	Our results show that the ependyma may be important in water movement in the brain and support the suggestion that AVP influences water exchange in mammalian brain tissue.	Water	130-135	arginine vasopressin	Homo sapiens	115-118
3778666-11	1986	Dialysis against H2O caused Fe.HTr (citrate), but not Fe.HTr (ceruloplasmin), to lose absorbance at 465 nm.	Water	17-20	telomerase RNA component	Homo sapiens	31-34
3778666-12	1986	The ESR profile of Fe.HTr (citrate), after dialysis against H2O, was reduced to multiple splittings and a lack of resolution of the central hyperfine structure.	Water	60-63	telomerase RNA component	Homo sapiens	22-25
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Water	195-198	telomerase RNA component	Homo sapiens	49-52
3488974-0	1986	Chemical reactions by pulsed ultrasound: memory effects in the formation of NO3- and NO2- in aerated water.	Water	101-106	NBL1, DAN family BMP antagonist	Homo sapiens	76-79
3742091-0	1986	1,3,5-Trichloro-2-(4-nitrophenoxy)benzene (CNP) in water, sediments, and shellfish of the Ishikari River.	Water	51-56	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	43-46
2944688-0	1986	Atrial natriuretic peptide: physiological release associated with natriuresis during water immersion in man.	Water	85-90	natriuretic peptide A	Homo sapiens	0-26
2944688-3	1986	During water immersion there was a highly significant (P less than 0.001) twofold increase of the mean plasma ANP concentration and a doubling of the mean urinary sodium excretion.	Water	7-12	natriuretic peptide A	Homo sapiens	110-113
3092662-2	1986	Activation of the sympathetic nervous system and the renin-angiotensin II-aldosterone system and increases in circulating arginine vasopressin maintain arterial blood pressure by producing systemic arteriolar vasoconstriction and the renal retention of salt and water.	Water	262-267	renin	Homo sapiens	53-58
2427542-0	1986	Transepithelial water flow regulates apical membrane retrieval in antidiuretic hormone-stimulated toad urinary bladder.	Water	16-21	arginine vasopressin	Homo sapiens	66-86
2427542-1	1986	Antidiuretic hormone (ADH) increases the osmotic water permeability (Posm) of toad urinary bladder.	Water	49-54	arginine vasopressin	Homo sapiens	0-20
2427542-1	1986	Antidiuretic hormone (ADH) increases the osmotic water permeability (Posm) of toad urinary bladder.	Water	49-54	arginine vasopressin	Homo sapiens	22-25
3020336-1	1986	Phospholipid metabolities and phospholipids containing arachidonic acid (AA) inhibited the antidiuretic hormone (ADH)-induced increase in transepithelial water flow in the toad urinary bladder, but had no effect on basal water flow when added to the serosal bathing solution.	Water	154-159	arginine vasopressin	Homo sapiens	91-111
3020336-1	1986	Phospholipid metabolities and phospholipids containing arachidonic acid (AA) inhibited the antidiuretic hormone (ADH)-induced increase in transepithelial water flow in the toad urinary bladder, but had no effect on basal water flow when added to the serosal bathing solution.	Water	154-159	arginine vasopressin	Homo sapiens	113-116
3020336-1	1986	Phospholipid metabolities and phospholipids containing arachidonic acid (AA) inhibited the antidiuretic hormone (ADH)-induced increase in transepithelial water flow in the toad urinary bladder, but had no effect on basal water flow when added to the serosal bathing solution.	Water	221-226	arginine vasopressin	Homo sapiens	91-111
3020336-1	1986	Phospholipid metabolities and phospholipids containing arachidonic acid (AA) inhibited the antidiuretic hormone (ADH)-induced increase in transepithelial water flow in the toad urinary bladder, but had no effect on basal water flow when added to the serosal bathing solution.	Water	221-226	arginine vasopressin	Homo sapiens	113-116
3020336-5	1986	PG have been reported to inhibit ADH-stimulated water flow by inhibiting adenylcyclase.	Water	48-53	arginine vasopressin	Homo sapiens	33-36
3092662-2	1986	Activation of the sympathetic nervous system and the renin-angiotensin II-aldosterone system and increases in circulating arginine vasopressin maintain arterial blood pressure by producing systemic arteriolar vasoconstriction and the renal retention of salt and water.	Water	262-267	arginine vasopressin	Homo sapiens	131-142
3768735-3	1986	Injections of 25 ng of angiotensin II into a lateral cerebral ventricle of the conscious rat elicited water intakes averaging 8 ml in 15 min with latencies usually less than 3 min.	Water	102-107	angiotensinogen	Rattus norvegicus	23-37
2942422-2	1986	Manipulation of an animal"s salt and water intake influences the synthesis, storage, and release of atriopeptin.	Water	37-42	natriuretic peptide A	Homo sapiens	100-111
3769414-4	1986	The resistance of the valve to a flow of air at a rate of 20 l min-1 is 2.2 mm of water at the inlet and 4.2 mm of water at the outlet.	Water	82-87	CD59 molecule (CD59 blood group)	Homo sapiens	63-68
3769414-4	1986	The resistance of the valve to a flow of air at a rate of 20 l min-1 is 2.2 mm of water at the inlet and 4.2 mm of water at the outlet.	Water	115-120	CD59 molecule (CD59 blood group)	Homo sapiens	63-68
3769414-5	1986	At a rate of flow of 100 l min-1 the corresponding figures are 8.9 and 24.6 mm of water.	Water	82-87	CD59 molecule (CD59 blood group)	Homo sapiens	27-32
2945719-5	1986	High plasma ANP concentrations in pathophysiological conditions with a high preload combined with salt and water retention is consistent with a physiological role of this hormone to correct hypervolemia by causing natriuresis and diuresis.	Water	107-112	natriuretic peptide A	Homo sapiens	12-15
3531301-6	1986	However, 3 days after the ewes returned to drinking water fetal plasma renin activity was significantly higher than it was prior to maternal ingestion of 0.17 M NaCl.	Water	52-57	renin	Homo sapiens	71-76
2943848-6	1986	The increase in concentration of ANP in plasma between dialyses, at a time when many patients are susceptible to sodium and water overload, and its return towards normal after dialysis supports the putative role of ANP as a circulating factor released in response to sodium and water accumulation.	Water	124-129	natriuretic peptide A	Homo sapiens	33-36
2943848-6	1986	The increase in concentration of ANP in plasma between dialyses, at a time when many patients are susceptible to sodium and water overload, and its return towards normal after dialysis supports the putative role of ANP as a circulating factor released in response to sodium and water accumulation.	Water	278-283	natriuretic peptide A	Homo sapiens	33-36
2943848-6	1986	The increase in concentration of ANP in plasma between dialyses, at a time when many patients are susceptible to sodium and water overload, and its return towards normal after dialysis supports the putative role of ANP as a circulating factor released in response to sodium and water accumulation.	Water	278-283	natriuretic peptide A	Homo sapiens	215-218
3782746-4	1986	AVP decreased during a water surcharge, but delayed elimination of water was observed.	Water	23-28	arginine vasopressin	Homo sapiens	0-3
3090234-2	1986	Arginine vasopressin, arginine vasotocin, oxytocin, desamino-8-D arginine vasopressin, forskolin and 8Br-cAMP stimulated hydro-osmotic water flux in a dose-dependent fashion.	Water	135-140	arginine vasopressin	Homo sapiens	9-20
3090234-0	1986	Mechanism of action and structural requirements of vasopressin analog inhibition of transepithelial water flux in toad urinary bladder.	Water	100-105	arginine vasopressin	Homo sapiens	51-62
3090234-2	1986	Arginine vasopressin, arginine vasotocin, oxytocin, desamino-8-D arginine vasopressin, forskolin and 8Br-cAMP stimulated hydro-osmotic water flux in a dose-dependent fashion.	Water	135-140	arginine vasopressin	Homo sapiens	74-85
2877401-1	1986	Noradrenaline (NA) and somatostatin (SOM) stimulate intestinal water and ion absorption and are found in mucosal nerve fibres and nerve terminals in submucous ganglia of the guinea-pig small intestine.	Water	63-68	somatostatin	Cavia porcellus	23-35
2425626-4	1986	Recently, VIP has been implicated in the regulation of mucus secretion in the respiratory tract, a process involving release of macromolecules from exocrine cells and transport of ions and water across the airway mucosa.	Water	189-194	vasoactive intestinal peptide	Canis lupus familiaris	10-13
3526084-10	1986	Significantly greater amounts of IR-GIP were released with 60 and 90 g glucose when given in 600 mL instead of 300 mL water.	Water	118-123	gastric inhibitory polypeptide	Homo sapiens	36-39
3730406-1	1986	Apolipoprotein B-100, the major protein constituent of human plasma low-density lipoproteins (LDL), was carboxyamidomethylated, digested with trypsin and the water-soluble tryptic peptides were coincubated with liposomes of dimyristoylphosphatidylcholine (DMPC).	Water	158-163	apolipoprotein B	Homo sapiens	0-20
3730584-3	1986	The maximum NSE concentration was measured in the frontal and occipital brain cortex, hippocampus, limbic cortex and hypothalamus (12-14 micrograms/mg of water-soluble protein), the minimum level was observed in the brain stem structures (3-6 micrograms/mg).	Water	154-159	enolase 2	Homo sapiens	12-15
3017491-7	1986	Adenosine 30 microM added to the superfusion fluid decreased electrically stimulated ACh release both in rats drinking tap water and rats drinking caffeine.	Water	123-128	nuclear RNA export factor 1	Rattus norvegicus	119-122
3017491-8	1986	In rats drinking tap water, caffeine added to the superfusion fluid at a concentration of 50 microM enhanced ACh release, while at 0.5 mM it decreased ACh output from the slices.	Water	21-26	nuclear RNA export factor 1	Rattus norvegicus	17-20
3747342-0	1986	Effect of vasopressin antagonist on water excretion in inferior vena cava constriction.	Water	36-41	arginine vasopressin	Rattus norvegicus	10-21
3768792-3	1986	Injections of 25 ng of angiotensin II into a lateral cerebral ventricle of the rat elicited water intakes averaging 7-8 mL in 15 min with latencies usually less than 3 min.	Water	92-97	angiotensinogen	Rattus norvegicus	23-37
2941271-2	1986	The effect of ANF on vasopressin secretion was greater in the water-deprived animal.	Water	62-67	arginine vasopressin	Rattus norvegicus	21-32
3747342-1	1986	Elevated levels of plasma arginine vasopressin (AVP) have been suggested to impair water excretion in congestive heart failure.	Water	83-88	arginine vasopressin	Rattus norvegicus	35-46
3747342-1	1986	Elevated levels of plasma arginine vasopressin (AVP) have been suggested to impair water excretion in congestive heart failure.	Water	83-88	arginine vasopressin	Rattus norvegicus	48-51
3508695-3	1986	The onset of pseudotumor cerebri also may be related to changes in vasopressin levels that affect brain water permeability.	Water	104-109	arginine vasopressin	Homo sapiens	67-78
3717373-4	1986	Water deprivation for 48 h increased the plasma vasopressin concentration (PADH) and 24-h urinary vasopressin excretion (UADHV) in SHR and WKY rats, but PMet-Enk was not altered.	Water	0-5	arginine vasopressin	Rattus norvegicus	48-59
3749229-6	1986	Rats down-shifted from a 32% to 4% sucrose solution generated response profiles more similar to rats shifted to plain tap water than rats maintained on a 32% sucrose solution and administered PIM.	Water	122-127	nuclear RNA export factor 1	Rattus norvegicus	118-121
3091626-4	1986	In the new assay, the plasma (milk) protein was precipitated with acetonitrile after dilution of the sample with water.	Water	113-118	Weaning weight-maternal milk	Bos taurus	30-34
3717156-6	1986	Two significantly higher rebounds were observed when comparing both treatments: for U after HD and for parathyroid hormone (PTH) after H HDF; however, PTH Cx/Cs ratios (ratios of the plasma water concentration of PTH at any postdialysis time to the plasma water concentration of PTH at the start of the run) were not different in both treatments, meaning that there was an increased PTH secretion in the early post H HDF hours in order to compensate for the larger PTH R with H HDF.	Water	256-261	parathyroid hormone	Homo sapiens	151-154
3717156-6	1986	Two significantly higher rebounds were observed when comparing both treatments: for U after HD and for parathyroid hormone (PTH) after H HDF; however, PTH Cx/Cs ratios (ratios of the plasma water concentration of PTH at any postdialysis time to the plasma water concentration of PTH at the start of the run) were not different in both treatments, meaning that there was an increased PTH secretion in the early post H HDF hours in order to compensate for the larger PTH R with H HDF.	Water	256-261	parathyroid hormone	Homo sapiens	151-154
3717156-6	1986	Two significantly higher rebounds were observed when comparing both treatments: for U after HD and for parathyroid hormone (PTH) after H HDF; however, PTH Cx/Cs ratios (ratios of the plasma water concentration of PTH at any postdialysis time to the plasma water concentration of PTH at the start of the run) were not different in both treatments, meaning that there was an increased PTH secretion in the early post H HDF hours in order to compensate for the larger PTH R with H HDF.	Water	256-261	parathyroid hormone	Homo sapiens	151-154
3717156-6	1986	Two significantly higher rebounds were observed when comparing both treatments: for U after HD and for parathyroid hormone (PTH) after H HDF; however, PTH Cx/Cs ratios (ratios of the plasma water concentration of PTH at any postdialysis time to the plasma water concentration of PTH at the start of the run) were not different in both treatments, meaning that there was an increased PTH secretion in the early post H HDF hours in order to compensate for the larger PTH R with H HDF.	Water	256-261	parathyroid hormone	Homo sapiens	151-154
3717156-6	1986	Two significantly higher rebounds were observed when comparing both treatments: for U after HD and for parathyroid hormone (PTH) after H HDF; however, PTH Cx/Cs ratios (ratios of the plasma water concentration of PTH at any postdialysis time to the plasma water concentration of PTH at the start of the run) were not different in both treatments, meaning that there was an increased PTH secretion in the early post H HDF hours in order to compensate for the larger PTH R with H HDF.	Water	256-261	parathyroid hormone	Homo sapiens	151-154
3717373-4	1986	Water deprivation for 48 h increased the plasma vasopressin concentration (PADH) and 24-h urinary vasopressin excretion (UADHV) in SHR and WKY rats, but PMet-Enk was not altered.	Water	0-5	arginine vasopressin	Rattus norvegicus	98-109
2941531-6	1986	Increasing cardiopulmonary volume during 3-h head-out water immersion was associated with an increase in ANP from 16.0 +/- 5.6 to 92.6 +/- 21.5 pmol/l (n = 7, P less than 0.01) followed by transient urinary sodium excretion.	Water	54-59	natriuretic peptide A	Homo sapiens	105-108
2941549-6	1986	These findings support the hypothesis that an increase in plasma ANF contributes to the hormonal and renal effects of immersion in water to the neck, suggesting that ANF has an important physiological role in modulating volume homeostasis in humans.	Water	131-136	natriuretic peptide A	Homo sapiens	65-68
2941549-6	1986	These findings support the hypothesis that an increase in plasma ANF contributes to the hormonal and renal effects of immersion in water to the neck, suggesting that ANF has an important physiological role in modulating volume homeostasis in humans.	Water	131-136	natriuretic peptide A	Homo sapiens	166-169
3011862-4	1986	In addition, one group of diabetic rats was treated with the angiotensin I converting enzyme inhibitor, enalapril, 15 mg/liter of drinking water.	Water	139-144	angiotensin I converting enzyme	Rattus norvegicus	61-92
2422957-9	1986	We conclude that conditions that prevail in vivo during antidiuresis, namely hypertonicity of the papillary interstitium, may augment vasopressin responsiveness through increments of collecting tubule cAMP and reductions of PGE2 which could, in concert, maximize water reabsorption in the collecting tubule.	Water	263-268	arginine vasopressin	Rattus norvegicus	134-145
3010730-0	1986	Polycations reduce vasopressin-induced water flow by endocytic removal of water channels.	Water	39-44	arginine vasopressin	Homo sapiens	19-30
3010730-1	1986	Several polycations added to the luminal solution were found to inhibit the vasopressin (ADH)-induced water flow in toad urinary bladder but not the ADH-induced increase in sodium transport or in urea permeability.	Water	102-107	arginine vasopressin	Homo sapiens	76-87
3087446-0	1986	PCB removal by conventional water treatment: effect of chemical coagulation and chlorination.	Water	28-33	pyruvate carboxylase	Homo sapiens	0-3
2870921-4	1986	With highly purified preparations of methylmalonyl-CoA mutase, effective tritium exchange from [5"-3H]adenosylcobalamin to water required the addition of methylmalonyl-CoA epimerase and of substrate (e.g. succinyl-CoA).	Water	123-128	methylmalonyl-CoA epimerase	Homo sapiens	154-181
3010738-0	1986	Time-dependent attenuation of water flow in antidiuretic hormone-treated toad bladder.	Water	30-35	arginine vasopressin	Homo sapiens	44-64
3457670-6	1986	After indomethacin, fractional free water clearance was reduced by an average of 26% at the zero, 2 and 4 fmol min-1 kg-1 infusion rates of AVP.	Water	36-41	CD59 molecule (CD59 blood group)	Homo sapiens	111-121
3708018-1	1986	Human serum albumin catalyzes proton exchange of the methyl group of the pyruvate molecule in heavy water.	Water	100-105	albumin	Homo sapiens	12-19
3516535-4	1986	Suppression of the renin-aldosterone system by water immersion alone was not significantly different from that obtained during water immersion plus dopamine blockade.	Water	47-52	renin	Homo sapiens	19-24
3516535-5	1986	On the contrary, plasma prolactin levels, previously suppressed during water immersion alone, were significantly stimulated during water immersion plus domperidone, thus indirectly suggesting a role of dopamine in mediating the blunted natriuresis seen during water immersion.	Water	71-76	prolactin	Homo sapiens	24-33
3516535-5	1986	On the contrary, plasma prolactin levels, previously suppressed during water immersion alone, were significantly stimulated during water immersion plus domperidone, thus indirectly suggesting a role of dopamine in mediating the blunted natriuresis seen during water immersion.	Water	131-136	prolactin	Homo sapiens	24-33
3516535-5	1986	On the contrary, plasma prolactin levels, previously suppressed during water immersion alone, were significantly stimulated during water immersion plus domperidone, thus indirectly suggesting a role of dopamine in mediating the blunted natriuresis seen during water immersion.	Water	131-136	prolactin	Homo sapiens	24-33
3457670-6	1986	After indomethacin, fractional free water clearance was reduced by an average of 26% at the zero, 2 and 4 fmol min-1 kg-1 infusion rates of AVP.	Water	36-41	arginine vasopressin	Homo sapiens	140-143
3516761-0	1986	Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment.	Water	23-28	filaggrin	Rattus norvegicus	0-9
3516761-0	1986	Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment.	Water	114-119	filaggrin	Rattus norvegicus	0-9
2937798-4	1986	Plasma alpha hANP rose to 77.8 +/- 27.6 in response to a 4.5% increase in plasma volume induced by water loading, increased further to 134.1 +/- 28.9 in response to a 23% volume increase induced by hypertonic saline, and fell to 70.2 +/- 15.8 pg/ml in response to a decrease in plasma volume after furosemide treatment (P less than 0.01-0.05).	Water	99-104	natriuretic peptide A	Homo sapiens	13-17
3516761-5	1986	This activation of filaggrin proteolysis was dependent on the drop in external water activity caused by the transition from an aqueous environment in utero to a dryer environment after birth and it could be blocked by maintaining a 100% humidity atmosphere around the newborn rat after birth.	Water	79-84	filaggrin	Rattus norvegicus	19-28
3516761-8	1986	The stratum corneum therefore has the ability to respond to changes in external humidity by altering the level of the stratum corneum where it converts its reserves of filaggrin into water binding amino acids, such that under humid conditions water binding components will be produced in only the most superficial stratum corneum, or even not produced at all.	Water	243-248	filaggrin	Rattus norvegicus	168-177
2937798-8	1986	Increases in urinary Na excretion and osmolar clearances were associated with a rise in plasma alpha hANP after water loading and hypertonic saline infusion (P less than 0.01-0.05), but changes in urine flow were mainly associated with alterations in AVP release.	Water	112-117	natriuretic peptide A	Homo sapiens	101-105
3007740-6	1986	The urinary excretion of vasopressin was not altered by the smaller dose of quinapril but was reduced by the larger dose, which increased water intake and urine excretion.	Water	138-143	arginine vasopressin	Rattus norvegicus	25-36
3964300-0	1986	Binding of DNA to albumin and transferrin modified by treatment with water-soluble carbodiimides.	Water	69-74	serotransferrin	Bos taurus	30-41
3964300-1	1986	N-Acylurea derivatives of albumin and transferrin prepared with the water-soluble carbodiimides N-ethyl-N"-(3-dimethylaminopropyl)carbodiimide and N-ethyl-N"-(3-trimethylpropylammonium)carbodiimide iodide have been found to bind different types of DNA.	Water	68-73	serotransferrin	Bos taurus	38-49
2874789-1	1986	In water, the purified 26 000-Mr membrane-bound DD-peptidase of Streptomyces K15 hydrolyses the ester carbonyl donor Ac2-L-Lys-D-Ala-D-lactate (release of D-lactate) and the amide carbonyl donor Ac2-L-Lys-D-Ala-D-Ala (release of D-alanine) with accumulation of acyl- (Ac2-L-Lys-D-alanyl-)enzyme.	Water	3-8	adenylate cyclase 2	Homo sapiens	117-120
2874789-1	1986	In water, the purified 26 000-Mr membrane-bound DD-peptidase of Streptomyces K15 hydrolyses the ester carbonyl donor Ac2-L-Lys-D-Ala-D-lactate (release of D-lactate) and the amide carbonyl donor Ac2-L-Lys-D-Ala-D-Ala (release of D-alanine) with accumulation of acyl- (Ac2-L-Lys-D-alanyl-)enzyme.	Water	3-8	adenylate cyclase 2	Homo sapiens	195-198
2874789-1	1986	In water, the purified 26 000-Mr membrane-bound DD-peptidase of Streptomyces K15 hydrolyses the ester carbonyl donor Ac2-L-Lys-D-Ala-D-lactate (release of D-lactate) and the amide carbonyl donor Ac2-L-Lys-D-Ala-D-Ala (release of D-alanine) with accumulation of acyl- (Ac2-L-Lys-D-alanyl-)enzyme.	Water	3-8	adenylate cyclase 2	Homo sapiens	195-198
2874789-4	1986	Under proper conditions, the acceptor activity of water and, in the case of the amide substrate, the acceptor activity of the released D-alanine can be totally overcome so that the two substrates are quantitatively converted into transpeptidated product Ac2-L-Lys-D-Ala-NH-X (and hydrolysis is prevented).	Water	50-55	adenylate cyclase 2	Homo sapiens	254-257
3004920-9	1986	Since it is possible that water absorption in the gut is also increased by PRL, multiple effects of PRL may be responsible for the diuresis observed in hyperprolactinemic rats.	Water	26-31	prolactin	Rattus norvegicus	75-78
3004920-9	1986	Since it is possible that water absorption in the gut is also increased by PRL, multiple effects of PRL may be responsible for the diuresis observed in hyperprolactinemic rats.	Water	26-31	prolactin	Rattus norvegicus	100-103
3634759-2	1986	In our hospital, patients are immersed in a tub of warm, continuously-flowing tap water.	Water	82-87	TUB bipartite transcription factor	Homo sapiens	44-47
3735922-0	1986	[Role of prolactin in disorders of water and salt metabolism in patients with hypertension].	Water	35-40	prolactin	Homo sapiens	9-18
3735922-1	1986	The relationship between water-salt balance and blood prolactin (Prl) level was examined in 22 male patients with essential hypertension, stages IB-IIA.	Water	25-30	prolactin	Homo sapiens	54-63
3699017-6	1986	HGL activity was found to be restricted to a triacylglycerol/water surface tension ranging from 8 dyn/cm to 13 dyn/cm.	Water	61-66	lipase F, gastric type	Homo sapiens	0-3
3707906-0	1986	Activation of porcine pancreatic phospholipase A2 by the presence of negative charges at the lipid-water interface.	Water	99-104	phospholipase A2 group IB	Homo sapiens	33-49
3963899-7	1986	In contrast to its effects on jejunum, CCK increased both water and electrolyte absorption from the ileum.	Water	58-63	cholecystokinin	Homo sapiens	39-42
3956133-4	1986	Decreases in the water thermal gradient (from 6.06 to 5.33 degrees C, P less than 0.05) in maximal value of heat loss (from 22.5 to 18.75 w.m-2, P less than 0.01) and in plethysmographic wave amplitude (from 25.8 to 14.6 mm, P less than 0.01) and increased HR (from 72 to 83 beats min-1) were observed in smokers.	Water	17-22	CD59 molecule (CD59 blood group)	Homo sapiens	281-286
3488026-8	1986	In addition, the immunosuppressive effect of a water-soluble nitrosourea derivative (ACNU) was determined in terms of the cytotoxicity of spleen lymphocytes, and the restoring effect of lymphokine-activated killer (LAK) cells and/or human recombinant interleukin-2 (rIL-2) on the cytotoxicities of spleen lymphocytes were examined in ACNU-treated C57 BL/6 mice.	Water	47-52	interleukin 2	Homo sapiens	251-264
3514280-7	1986	Thus, the intrarenal effects of AngII provide a mechanism for stabilizing the GFR and excretion of metabolic waste products while causing sodium and water retention, thereby helping to regulate body fluid volumes and arterial pressure.	Water	149-154	angiotensinogen	Homo sapiens	32-37
3711889-3	1986	Calorimetric studies of the effect of superoxide dismutase and/or catalase on the reduction of dioxygen into water by dithionite in oxyhemoglobin have been carried out and the results compared with those in red cell hemolysates.	Water	109-114	catalase	Homo sapiens	66-74
3714779-4	1986	Access to both water and ethanol remained ad lib.	Water	15-20	leucine rich repeat containing 15	Rattus norvegicus	45-48
3006514-6	1986	Synthetic PTH (1-34) inhibited vasopressin-stimulated water flow only at a high concentration (1 microgram/ml).	Water	54-59	parathyroid hormone	Homo sapiens	10-13
3006248-4	1986	These results suggest that atriopeptin III acts proximal to cyclic adenosine monophosphate formation to directly affect vasopressin-stimulated water transport in the mammalian nephron.	Water	143-148	natriuretic peptide A	Homo sapiens	27-38
3006248-4	1986	These results suggest that atriopeptin III acts proximal to cyclic adenosine monophosphate formation to directly affect vasopressin-stimulated water transport in the mammalian nephron.	Water	143-148	arginine vasopressin	Homo sapiens	120-131
3006506-1	1986	Binding of tritium-labeled vasopressin [( 3H]AVP) to a broken epithelial cell preparation of the toad"s urinary bladder has been related to hormonal action on water and urea transport across the intact tissue.	Water	159-164	arginine vasopressin	Homo sapiens	27-38
3006514-6	1986	Synthetic PTH (1-34) inhibited vasopressin-stimulated water flow only at a high concentration (1 microgram/ml).	Water	54-59	arginine vasopressin	Homo sapiens	31-42
3006506-1	1986	Binding of tritium-labeled vasopressin [( 3H]AVP) to a broken epithelial cell preparation of the toad"s urinary bladder has been related to hormonal action on water and urea transport across the intact tissue.	Water	159-164	arginine vasopressin	Homo sapiens	45-48
3006506-3	1986	Half-maximal urea and water permeability responses were observed with 3.1 and 5.6 nM AVP, respectively, although half-maximal receptor saturation required considerably higher concentrations of hormone (less than 500 nM).	Water	22-27	arginine vasopressin	Homo sapiens	85-88
3006514-8	1986	These results demonstrate that PTH inhibits water transport beyond the generation of cyclic AMP.	Water	44-49	parathyroid hormone	Homo sapiens	31-34
3006514-0	1986	Parathyroid hormone inhibits water flow in the isolated toad bladder.	Water	29-34	parathyroid hormone	Homo sapiens	0-19
3006514-9	1986	That the effect of PTH was abolished in a low-Ca medium or by pretreatment with lanthanum suggests that cell Ca uptake is required for the effect of PTH on water transport.	Water	156-161	parathyroid hormone	Homo sapiens	19-22
3006514-1	1986	These experiments studied the effect of parathyroid hormone (PTH) (1-84) on water and Ca transport in isolated toad bladder sacs and toad bladder epithelial cells.	Water	76-81	parathyroid hormone	Homo sapiens	61-64
3006514-9	1986	That the effect of PTH was abolished in a low-Ca medium or by pretreatment with lanthanum suggests that cell Ca uptake is required for the effect of PTH on water transport.	Water	156-161	parathyroid hormone	Homo sapiens	149-152
3006514-2	1986	Serosal addition of PTH significantly inhibited maximal water flow induced by vasopressin or exogenous cyclic AMP.	Water	56-61	parathyroid hormone	Homo sapiens	20-23
3006514-2	1986	Serosal addition of PTH significantly inhibited maximal water flow induced by vasopressin or exogenous cyclic AMP.	Water	56-61	arginine vasopressin	Homo sapiens	78-89
3006514-10	1986	That prostaglandin inhibitors also block the effect of PTH on vasopressin-stimulated water flow suggests that prostaglandin synthesis is required for the effect.	Water	85-90	parathyroid hormone	Homo sapiens	55-58
2423146-7	1986	Lysozyme is selectively adsorbed on all of the high water content hydrogels and mucin is the major protein component for the pure PHEMA type of lenses.	Water	52-57	lysozyme	Homo sapiens	0-8
3006514-10	1986	That prostaglandin inhibitors also block the effect of PTH on vasopressin-stimulated water flow suggests that prostaglandin synthesis is required for the effect.	Water	85-90	arginine vasopressin	Homo sapiens	62-73
3006514-11	1986	These data suggest that the effect of PTH on water flow is mediated by an increased cellular uptake of Ca that stimulates prostaglandin release.	Water	45-50	parathyroid hormone	Homo sapiens	38-41
3006514-12	1986	Prostaglandin release, in turn, appears to mediate the inhibitory effect of PTH on vasopressin-stimulated water transport.	Water	106-111	parathyroid hormone	Homo sapiens	76-79
3006514-12	1986	Prostaglandin release, in turn, appears to mediate the inhibitory effect of PTH on vasopressin-stimulated water transport.	Water	106-111	arginine vasopressin	Homo sapiens	83-94
3710313-2	1986	SHR treated with 10% sucrose solution as drinking water for 3 months exhibited an impaired glucose tolerance with higher serum insulin levels and a reduction of sigma delta IRI/sigma delta BS.	Water	50-55	insulin	Homo sapiens	127-134
2871908-1	1986	Water intake, induced by subcutaneous (SC) administration of angiotensin II (AII, 200 micrograms/kg), isoproterenol (25 micrograms/kg), 5-hydroxytryptophan (25 mg/kg), and bethanechol (8 mg/kg), was reduced completely to control level by administration of either an intragastric (IG) or intraperitoneal (IP) load of distilled water (3% of body weight) prior to administration of the dipsogen.	Water	0-5	angiotensinogen	Rattus norvegicus	61-75
2871908-1	1986	Water intake, induced by subcutaneous (SC) administration of angiotensin II (AII, 200 micrograms/kg), isoproterenol (25 micrograms/kg), 5-hydroxytryptophan (25 mg/kg), and bethanechol (8 mg/kg), was reduced completely to control level by administration of either an intragastric (IG) or intraperitoneal (IP) load of distilled water (3% of body weight) prior to administration of the dipsogen.	Water	0-5	angiotensinogen	Rattus norvegicus	77-80
3526580-9	1986	All these findings indicated that P. berghei-infected mice caused a depressed catalase activity in red cells and liver which was possibly due to the catalatic function in detoxifying the increased H2O2 to water and free oxygen.	Water	205-210	catalase	Mus musculus	78-86
2942846-2	1986	The ICV injection of ANF attenuated water intake induced by AII or 48-hr water deprivation.	Water	36-41	angiotensinogen	Rattus norvegicus	60-63
2939099-3	1986	The bandwidths of several polypeptides related to human beta-endorphin have been investigated with different n-alkylsilica stationary phases and different elution gradients of 0.1% trifluoroacetic acid-water-acetonitrile mobile phases.	Water	202-207	proopiomelanocortin	Homo sapiens	56-70
3518307-1	1986	The present investigation has revealed that in mice, immunized with preparation HC-4 (an immunostimulating agent consisting of water-soluble antigenic complexes obtained from 4 opportunistic microorganisms: Klebsiella pneumoniae, staphylococcus, Proteus and Escherichia coli K-100 having a common antigen with Haemophilus influenzae) and challenged with K. pneumoniae culture on day 7 after immunization, the complete elimination of K. pneumoniae from the blood occurs within 24 hours.	Water	127-132	heterochromatin, Chr 4	Mus musculus	80-84
2938978-3	1986	Anti-ANP antiserum, which can neutralize endogenous ANP, potentiated the water intake induced by water deprivation or angiotensin II (AII) injection in rats.	Water	73-78	angiotensinogen	Rattus norvegicus	118-132
3005917-1	1986	The following study was designed to evaluate plasma beta-endorphin (beta-EP) variations in healthy volunteers during thermoneutral head-out water immersion while prevalently in the standing position.	Water	140-145	proopiomelanocortin	Homo sapiens	52-66
3005917-1	1986	The following study was designed to evaluate plasma beta-endorphin (beta-EP) variations in healthy volunteers during thermoneutral head-out water immersion while prevalently in the standing position.	Water	140-145	proopiomelanocortin	Homo sapiens	68-75
3005917-4	1986	Plasma beta-EP levels significantly decreased during water immersion from a value of 12.71 +/- 2.04 pmol/l to 7.46 +/- 1.09 pmol/l at 15 min (P less than 0.05) and to 6.08 +/- 1.87 pmol/l at 30 min (P less than 0.01).	Water	53-58	proopiomelanocortin	Homo sapiens	7-14
3005917-7	1986	Further studies are necessary in order to clarify the mechanism involved in beta-EP decrease in normal subjects during thermoneutral head-out water immersion.	Water	142-147	proopiomelanocortin	Homo sapiens	76-83
3512151-9	1986	In order to better understand the etiology of the high basal AVP plasma levels observed in group 3, AVP response to a standard water load was studied in eight supplementary heart-transplant recipients: 81.5% of the water load was excreted over 3 h and plasma AVP fell significantly (x0.76).	Water	127-132	arginine vasopressin	Homo sapiens	100-103
3512151-9	1986	In order to better understand the etiology of the high basal AVP plasma levels observed in group 3, AVP response to a standard water load was studied in eight supplementary heart-transplant recipients: 81.5% of the water load was excreted over 3 h and plasma AVP fell significantly (x0.76).	Water	127-132	arginine vasopressin	Homo sapiens	100-103
2938978-3	1986	Anti-ANP antiserum, which can neutralize endogenous ANP, potentiated the water intake induced by water deprivation or angiotensin II (AII) injection in rats.	Water	73-78	angiotensinogen	Rattus norvegicus	134-137
3946641-3	1986	However, plasma AVP was reduced to basal levels when the rats were given either free access to drinking water or intragastric water loads that diluted plasma osmolality by only 3-6% despite continued hypovolemia.	Water	104-109	arginine vasopressin	Rattus norvegicus	16-19
3084274-8	1986	It is suggested that the decrease in free water clearance may be attributed to both an elevated level of vasopressin and a reduced glomerular filtration rate.	Water	42-47	arginine vasopressin	Homo sapiens	105-116
3510912-4	1986	The liver contains the most important of these detoxification systems: the cytochrome P-450-dependent mixed function oxidase (MFO) and several conjugation enzymes, e.g., sulfotransferase, glucuronyl transferase, and glutathione transferase, which convert lipophilic compounds to more water-soluble products to enhance their excretion.	Water	284-289	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	75-91
3700501-2	1986	During a water loading, the plasmatic cortisol rates stayed more higher by cancerous subjects than by controls (but not the plasmatic aldosterone rates); nevertheless, the vasopressin secretion rates could be considered as more higher yet in cancerous subjects because the free water clearances were significantly lowered by these patients.	Water	9-14	arginine vasopressin	Homo sapiens	172-183
3518294-1	1986	Lipopolysaccharide extracted with phenol-water from Leptospira interrogans serovar copenhageni strain Shibaura (L-LPS) showed various biological activities.	Water	41-46	toll-like receptor 4	Mus musculus	114-117
2417837-3	1986	In water, besides the aggregation phenomenon, the monomeric substance P presents a complex conformational equilibrium.	Water	3-8	tachykinin precursor 1	Homo sapiens	60-71
3080992-1	1986	Water-soluble carbodiimide-catalyzed cross-linking of purified cytochrome P-450 LM2, cytochrome b5, and NADPH-cytochrome P-450 reductase was used to identify stable complexes formed between these proteins.	Water	0-5	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-79
3080992-1	1986	Water-soluble carbodiimide-catalyzed cross-linking of purified cytochrome P-450 LM2, cytochrome b5, and NADPH-cytochrome P-450 reductase was used to identify stable complexes formed between these proteins.	Water	0-5	cytochrome p450 oxidoreductase	Homo sapiens	104-136
17769644-0	1986	Identification of hydroxymethanesulfonate in fog water.	Water	49-54	zinc finger protein, FOG family member 1	Homo sapiens	45-48
3697792-3	1986	When water was withheld for 1 hr following SC administration of AII, water intake was similar to that of rats administered AII and given immediate access to water.	Water	69-74	angiotensinogen	Rattus norvegicus	64-67
3697792-3	1986	When water was withheld for 1 hr following SC administration of AII, water intake was similar to that of rats administered AII and given immediate access to water.	Water	69-74	angiotensinogen	Rattus norvegicus	64-67
2943141-12	1986	Angiotensin II exerts about the same effects as norepinephrine--vasoconstriction, rerouting of blood within the kidney and preferential vasoconstriction of the efferent arterioles--all changes contributing to the retention of salt and water.	Water	235-240	angiotensinogen	Homo sapiens	0-14
2833070-0	1986	Effect of water immersion on serum ACTH and cortisol concentration in patients with acute renal failure and in healthy individuals.	Water	10-15	proopiomelanocortin	Homo sapiens	35-39
2430427-14	1986	The NKA- and ELE-like components were also identified by HPLC in water extracts of human ureter.	Water	65-70	tachykinin precursor 1	Homo sapiens	4-7
3017059-0	1986	Effects of ACE inhibition on renal regulation of salt and water.	Water	58-63	angiotensin I converting enzyme	Homo sapiens	11-14
3017059-8	1986	These changes in renal handling of salt and water are primarily caused by decreased AII.	Water	44-49	NLR family pyrin domain containing 3	Homo sapiens	84-87
3004215-1	1986	The permeability of human amnion to tritiated water is reduced in the presence of both human and ovine prolactin.	Water	46-51	prolactin	Homo sapiens	103-112
3544726-1	1986	In ten human subjects water immersion produced a two-fold diuresis and a three-fold increase in sodium secretion together with a marked fall in plasma renin activity and aldosterone.	Water	22-27	renin	Homo sapiens	151-156
3006712-5	1986	showed an increase in urinary excretion of bradykinin accompanied by increases in urinary water and sodium excretion.	Water	90-95	kininogen 1	Canis lupus familiaris	43-53
18553846-0	1986	Preparation and properties of stable water-insoluble derivatives of glutathione S-aryltransferase.	Water	37-42	glutathione S-transferase mu 1	Homo sapiens	68-97
3948857-0	1986	Central venous pressure and plasma arginine vasopressin in man during water immersion combined with changes in blood volume.	Water	70-75	arginine vasopressin	Homo sapiens	44-55
2423023-2	1986	Although it is apparent that some epithelial hormone responses, such as the vasopressin-induced change in water permeability, utilize this mechanism, the mechanism of some other responses remains uncertain.	Water	106-111	arginine vasopressin	Homo sapiens	76-87
3519238-5	1986	Water loading-induced suppression of Ang II and AVP was inhibited by captopril therapy.	Water	0-5	angiotensinogen	Homo sapiens	37-43
3004215-3	1986	The present study sought to confirm an epithelial site of action of prolactin on the permeability of amnionic membrane to tritiated water.	Water	132-137	prolactin	Homo sapiens	68-77
3004215-6	1986	However, when ovine prolactin was presented to the fetal surface of amnion, only intact membrane displayed decreased permeability to tritiated water.	Water	143-148	prolactin	Homo sapiens	20-29
3004215-8	1986	The results indicate that the permeability of human amnion to water is influenced principally by cells of the epithelium in response to prolactin.	Water	62-67	prolactin	Homo sapiens	136-145
3546211-2	1986	Dichloramine-T, a water insoluble derivative of chloramine-T showed excellent properties as an iodination reagent, for the preparation of radiolabeled insulin for use in radioimmunoassay.	Water	18-23	insulin	Homo sapiens	151-158
2438485-1	1986	The purpose of this study was to determine if generation of angiotensin II (ANG II) locally within the intestine can influence ion and water absorption.	Water	135-140	angiotensinogen	Rattus norvegicus	60-74
2438485-1	1986	The purpose of this study was to determine if generation of angiotensin II (ANG II) locally within the intestine can influence ion and water absorption.	Water	135-140	angiotensinogen	Rattus norvegicus	76-82
2434767-1	1986	Vasopressin increases the permeability of responsive epithelia for a variety of chemical species, such as sodium, urea, water, and lipophilic molecules.	Water	120-125	arginine vasopressin	Homo sapiens	0-11
2438485-2	1986	Addition of ANG II to the serosal surface of isolated segments of rat jejunum significantly increased sodium and water absorption.	Water	113-118	angiotensinogen	Rattus norvegicus	12-18
2434770-1	1986	Vasopressin is the primary physiological factor regulating renal water reabsorption in mammals.	Water	65-70	arginine vasopressin	Rattus norvegicus	0-11
3029207-4	1986	If the animals were treated with superoxide dismutase (SOD) at the onset of EAU, aqueous humor cell count was significantly lower than that of control (i.e., without SOD treatment).	Water	76-79	superoxide dismutase 1	Homo sapiens	55-58
2434770-2	1986	Inhibitors of vasopressin-stimulated water reabsorption have previously been used as water diuretic agents in both experimental animals and man.	Water	37-42	arginine vasopressin	Homo sapiens	14-25
2434770-2	1986	Inhibitors of vasopressin-stimulated water reabsorption have previously been used as water diuretic agents in both experimental animals and man.	Water	85-90	arginine vasopressin	Homo sapiens	14-25
2434770-3	1986	The present studies describe and characterize the pharmacological effects of the potent vasopressin antagonist desGly d(CH2)5D-Tyr(Et)VAVP (SK&F 101926) and related analogs on renal water and solute excretion in conscious rats.	Water	186-191	arginine vasopressin	Rattus norvegicus	88-99
2434770-6	1986	SK&F 101926 antagonized, in a competitive fashion, exogenous vasopressin-stimulated antidiuresis in conscious water-loaded rats.	Water	114-119	arginine vasopressin	Rattus norvegicus	65-76
2434773-1	1986	The role of vasopressin in the kidney has classically been considered to result from its ability to increase water permeability in the collecting duct.	Water	109-114	arginine vasopressin	Homo sapiens	12-23
2434777-5	1986	Two days after surgery, sham-lesioned, water-deprived rats displayed decreased vasopressin immunostaining density compared to normal controls, and adipsic AV3V-lesioned rats displayed increased vasopressin immunoreactivity throughout the magnocellular-hypophyseal system.	Water	39-44	arginine vasopressin	Rattus norvegicus	79-90
3029207-4	1986	If the animals were treated with superoxide dismutase (SOD) at the onset of EAU, aqueous humor cell count was significantly lower than that of control (i.e., without SOD treatment).	Water	76-79	superoxide dismutase 1	Homo sapiens	33-53
3512896-2	1986	The sample was found to be highly heterogeneous in terms of the magnitude of the body"s water-filled spaces in relation to plasma renin activity (PRA) and the cooking salt gustatory sensitivity threshold, examined in the presence of various salt diets and diuretic treatments.	Water	88-93	renin	Homo sapiens	130-135
3031349-0	1986	Role of inhibitory and stimulative effects of prostaglandins on vasopressin-stimulated osmotic water flow in the toad bladder.	Water	95-100	arginine vasopressin	Homo sapiens	64-75
3639155-2	1986	The rats were housed in individual metabolic cages and were allowed free access to food having normal sodium content and to tap water.	Water	128-133	nuclear RNA export factor 1	Rattus norvegicus	124-127
3031349-3	1986	Indomethacin enhanced both the vasopressin- and cyclic AMP-stimulated water flow across the toad bladder.	Water	70-75	arginine vasopressin	Homo sapiens	31-42
2948073-6	1986	ANF release was stimulated by head-out water immersion both in normotensive controls and cirrhotic patients.	Water	39-44	natriuretic peptide A	Homo sapiens	0-3
3748120-1	1986	A study has been made of surface pressure (pi) and maximum shear stress (Ps) (at a constant shear rate) of decane-water interface on which bovine serum albumin (BSA) and its complexes with dextran sulfate (DS) were adsorbed.	Water	114-119	albumin	Homo sapiens	146-159
3031349-4	1986	However, the half maximum activation dose for vasopressin was 2 X 10(-10) M, but for cyclic AMP, as much as 3 X 10(-8) M. The PGE2 inhibited both vasopressin- and cyclic AMP-stimulated water flow.	Water	185-190	arginine vasopressin	Homo sapiens	146-157
3031349-7	1986	Thus, PGE2 may suppress vasopressin-stimulated water flow at a site of cyclic AMP generation under physiological conditions.	Water	47-52	arginine vasopressin	Homo sapiens	24-35
3031349-8	1986	Thromboxane B2 (TXB2) enhanced vasopressin-stimulated water flow but not cyclic AMP-stimulated one.	Water	54-59	arginine vasopressin	Homo sapiens	31-42
2952866-2	1986	Upon addition of MgATP, phenyldicarbaundecaborane (PCB-) and tetraphenylboron (TPB-) are taken up by the SR vesicles, while tetraphenylphosphonium (TPP+) is released into the water phase.	Water	175-180	pyruvate carboxylase	Homo sapiens	51-54
2946974-3	1986	Also in the water-deprived rat, this treatment leads to a strong decrease of plasma VP levels.	Water	12-17	arginine vasopressin	Rattus norvegicus	84-86
3796789-2	1986	injection of leumorphin through an implanted cannula into the lateral ventricle of rats dose-dependently inhibited water intake induced by water deprivation, angiotensin II (AII) and carbachol.	Water	115-120	angiotensinogen	Rattus norvegicus	158-172
3001564-0	1986	Increased number of angiotensin II binding sites determined by autoradiography in anterior pituitary of water-deprived and Brattleboro rats.	Water	104-109	angiotensinogen	Rattus norvegicus	20-34
3001564-7	1986	Five days of water deprivation increased the number of ANG-binding sites by 86.5% and by 36.9% in LE and HZ rats, respectively, when compared to their water-satiated controls.	Water	13-18	angiotensinogen	Rattus norvegicus	55-58
3001564-7	1986	Five days of water deprivation increased the number of ANG-binding sites by 86.5% and by 36.9% in LE and HZ rats, respectively, when compared to their water-satiated controls.	Water	151-156	angiotensinogen	Rattus norvegicus	55-58
3001564-8	1986	After 1 day of water deprivation, the ANG-binding site density increased by 19.4% in DI rats.	Water	15-20	angiotensinogen	Rattus norvegicus	38-41
3001564-10	1986	The binding affinity constant of the agonist for the ANG-binding sites compared with LE rats was decreased in both HZ and DI rats (-27.5 and -19.4%) and was also decreased after 5 days of dehydration in LE rats (-34%) when compared to the water-satiated state.	Water	239-244	angiotensinogen	Rattus norvegicus	53-56
3774909-3	1986	In the first experiment, sham-operated and adrenal demedullated rats were provided with 1.5% NaCl or tap water for drinking for 5 days.	Water	105-110	nuclear RNA export factor 1	Rattus norvegicus	101-104
3951675-6	1986	Water deprivation for 24 and 48 h significantly elevated both the plasma AVP concentration and the concentration of AVP in the hypothalamus and in the amygdala-temporal cortex samples.	Water	0-5	arginine vasopressin	Rattus norvegicus	73-76
3951675-6	1986	Water deprivation for 24 and 48 h significantly elevated both the plasma AVP concentration and the concentration of AVP in the hypothalamus and in the amygdala-temporal cortex samples.	Water	0-5	arginine vasopressin	Rattus norvegicus	116-119
3951675-7	1986	The increases in AVP after water deprivation are limited to these two regions and are quantitatively much lower than after peripheral administration.	Water	27-32	arginine vasopressin	Rattus norvegicus	17-20
3952182-2	1986	The injection of carbachol or angiotensin II into MSA and LSA of water sated rats evoked a preference for the sweet tasting saccharin solution and water.	Water	65-70	angiotensinogen	Rattus norvegicus	30-44
3952182-2	1986	The injection of carbachol or angiotensin II into MSA and LSA of water sated rats evoked a preference for the sweet tasting saccharin solution and water.	Water	147-152	angiotensinogen	Rattus norvegicus	30-44
3952182-9	1986	These results indicate that both the carbachol and angiotensin II induce the ingestion of saccharin, NaCl and water.	Water	110-115	angiotensinogen	Rattus norvegicus	51-65
2430346-1	1986	Cytochalasin is known to inhibit the antidiuretic hormone-induced hydro-osmotic response (bulk water flow) in the amphibian urinary bladder without altering hormone-stimulated diffusional water permeability or short-circuit current.	Water	95-100	arginine vasopressin	Homo sapiens	37-57
3541090-10	1986	Human gastric lipase activity was found to be restricted to triacylglycerol/water surface tensions ranging from 8 to 13 dynes/cm.	Water	76-81	lipase F, gastric type	Homo sapiens	6-20
3809718-2	1986	In humans, the excretion rate of both BK and LBK decreased markedly 90 min after the water load.	Water	85-90	kininogen 1	Homo sapiens	38-40
3002355-6	1985	Carbachol, which inhibits ADH-induced water flow, also stimulated 32P incorporation into PA and PI.	Water	38-43	arginine vasopressin	Homo sapiens	26-29
4066705-2	1985	The activation of cobra venom phospholipase A2 by activators (containing phosphorylcholine moieties) appears to depend upon the aggregation state of the enzyme, and the presence of a lipid-water interface.	Water	189-194	phospholipase A2 group IB	Homo sapiens	30-46
4066713-3	1985	Apo-E forms a stable monolayer at the air-water interface with a collapse pressure of 14 dynes/cm and with a limiting molecular area of 21 A2/amino acid.	Water	42-47	apolipoprotein E	Homo sapiens	0-5
2416347-2	1985	Such a membrane-mimetic system resembles the aqueous spaces of native myelin sheath in terms of physicochemical properties as reflected in the high affinity of MBP for interfacial bound water.	Water	186-191	myelin basic protein	Bos taurus	160-163
3877721-4	1985	Although MGP has a very low solubility in water compared to BGP, there is no hydrophobic domain in MGP which could account for its insolubility, and the overall fraction of hydrophobic residues is 32% for MGP compared to 43% for BGP.	Water	42-47	matrix Gla protein	Bos taurus	9-12
3714834-6	1986	Both vasopressin-deficient homozygous Brattleboro rats and their heterozygous littermates (with preserved vasopressin synthesis) began to consume solid food and water at the age of 16 days and their intake of maternal milk was terminated about the 27th day of age.	Water	161-166	arginine vasopressin	Rattus norvegicus	5-16
4063831-3	1985	After water deprivation for 24 h, both AVP in plasma and DA in the neurointermediate lobe increased without any changes in AVP in the neurointermediate lobe.	Water	6-11	arginine vasopressin	Rattus norvegicus	39-42
4063831-4	1985	Water deprivation for 48-72 h caused further increases in both AVP in plasma and DA in the neurointermediate lobe with a significant decrease in AVP in the neurointermediate lobe.	Water	0-5	arginine vasopressin	Rattus norvegicus	63-66
4063831-4	1985	Water deprivation for 48-72 h caused further increases in both AVP in plasma and DA in the neurointermediate lobe with a significant decrease in AVP in the neurointermediate lobe.	Water	0-5	arginine vasopressin	Rattus norvegicus	145-148
4063831-5	1985	Rehydration for 24 h subsequent to 72 h of water deprivation made AVP in plasma and DA in the neurointermediate lobe return to the values of normally hydrated rats, whereas AVP in the neurointermediate lobe was still depressed.	Water	43-48	arginine vasopressin	Rattus norvegicus	66-69
4053513-0	1985	A vasopressin-mediated diminution of potassium excretion in water-loaded man.	Water	60-65	arginine vasopressin	Homo sapiens	2-13
4063831-5	1985	Rehydration for 24 h subsequent to 72 h of water deprivation made AVP in plasma and DA in the neurointermediate lobe return to the values of normally hydrated rats, whereas AVP in the neurointermediate lobe was still depressed.	Water	43-48	arginine vasopressin	Rattus norvegicus	173-176
2932797-3	1985	Thus, ANF probably intervenes in the short- and long-term control of water and electrolyte balance and of blood pressure.	Water	69-74	natriuretic peptide A	Homo sapiens	6-9
4052780-2	1985	Infusions of AII enhanced the salt appetite and led to rapid retention of both sodium and water.	Water	90-95	angiotensinogen	Rattus norvegicus	13-16
4052780-4	1985	Water intake was greater in both AII- and CBC-infused than in vehicle-infused rats and water balances increased during CBC infusion, causing severe dilution of plasma osmolality, sodium and potassium concentrations.	Water	0-5	angiotensinogen	Rattus norvegicus	33-36
2933129-0	1985	Inhibition of spontaneous or angiotensin II-stimulated water intake by atrial natriuretic factor.	Water	55-60	angiotensinogen	Rattus norvegicus	29-43
2933129-3	1985	The primary actions of these peptides lead to a reduction in plasma and extracellular fluid volume by eliciting natriuresis and diuresis, and by opposing the action of other peptidergic systems such as the vasopressin and angiotensin systems that promote water retention and enhance drinking behavior.	Water	255-260	arginine vasopressin	Rattus norvegicus	206-217
2933129-7	1985	Most remarkably, APIII given IVT also inhibited the potent dipsogenic action of angiotensin II (AII) on both water and a 2% NaCl solution intake.	Water	109-114	angiotensinogen	Rattus norvegicus	80-94
2933129-7	1985	Most remarkably, APIII given IVT also inhibited the potent dipsogenic action of angiotensin II (AII) on both water and a 2% NaCl solution intake.	Water	109-114	angiotensinogen	Rattus norvegicus	96-99
4053513-1	1985	Intravenous vasopressin (1-3 mu-units min-1 kg-1) had an antidiuretic effect on water-loaded man and also diminished potassium excretion.	Water	80-85	arginine vasopressin	Homo sapiens	12-23
4052179-3	1985	We studied seven pregnant patients with a diagnosis of mild preeclampsia to assess the role of vasopressin, serum protein, and glomerular function in the renal excretion of water.	Water	173-178	arginine vasopressin	Homo sapiens	95-106
2865701-3	1985	The high catecholamine values in cirrhotic patients and the activation of the renin angiotensin-aldosterone system suggest the use of beta-blockers to reduce sodium-water retention.	Water	165-170	renin	Homo sapiens	78-83
3931483-0	1985	Blockade of colchicine-induced inhibition of vasopressin-stimulated osmotic water flow: failure to influence microtubule formation.	Water	76-81	arginine vasopressin	Homo sapiens	45-56
3931483-1	1985	Colchicine inhibits vasopressin-induced osmotic water flow across isolated toad urinary bladder.	Water	48-53	arginine vasopressin	Homo sapiens	20-31
3931483-4	1985	Since it has been demonstrated recently that cyclooxygenase inhibitors (meclofenamic acid) abrogate the inhibition by colchicine of vasopressin-stimulated water flow, we tested by stereological criteria the hypothesis that colchicine in the presence of meclofenamic acid does not prevent the polymerization of tubulin.	Water	155-160	arginine vasopressin	Homo sapiens	132-143
3916340-3	1985	We propose that the solute determines the behaviour of the adjacent first interfacial water layer (I1); that the bulk solution determines the behaviour of the third interfacial water layer (I3), and that both I1 and I3 compete for hydrogen-bonding interactions with the intervening water layer (I2), which can be thought of as a transition layer.	Water	86-91	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	209-218
3916340-3	1985	We propose that the solute determines the behaviour of the adjacent first interfacial water layer (I1); that the bulk solution determines the behaviour of the third interfacial water layer (I3), and that both I1 and I3 compete for hydrogen-bonding interactions with the intervening water layer (I2), which can be thought of as a transition layer.	Water	177-182	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	209-218
3916340-3	1985	We propose that the solute determines the behaviour of the adjacent first interfacial water layer (I1); that the bulk solution determines the behaviour of the third interfacial water layer (I3), and that both I1 and I3 compete for hydrogen-bonding interactions with the intervening water layer (I2), which can be thought of as a transition layer.	Water	177-182	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	209-218
2997159-8	1985	From a resting value of approximately 30 meq/liter of cell water, internal Na+ in FMLP-stimulated cells rose exponentially to reach a concentration of approximately 60 meq/liter by 10-15 min.	Water	59-64	formyl peptide receptor 1	Homo sapiens	82-86
4060971-6	1985	This contrasted with the potent natriuretic and weak kaliuretic action of vasopressin in water loaded Inactin anaesthetised rats.	Water	89-94	arginine vasopressin	Rattus norvegicus	74-85
3938241-2	1985	The rats were placed into individual metabolic cages and allowed free access to food having normal sodium content and to tap water.	Water	125-130	nuclear RNA export factor 1	Rattus norvegicus	121-124
2996648-6	1985	While CSL and 5-PC both reflect the high ordering of the bilayer close to the lipid-water interface, CSL appears to be located close enough to the water for the nitroxide to be involved in hydrogen bonding with water molecules.	Water	147-152	chorionic somatomammotropin hormone like 1	Homo sapiens	101-104
2996648-6	1985	While CSL and 5-PC both reflect the high ordering of the bilayer close to the lipid-water interface, CSL appears to be located close enough to the water for the nitroxide to be involved in hydrogen bonding with water molecules.	Water	147-152	chorionic somatomammotropin hormone like 1	Homo sapiens	101-104
2996648-9	1985	The results from CSL indicate that close to the lipid-water interface the DPPC molecule is oriented approximately perpendicular to the bilayer in these low water-content systems.	Water	54-59	chorionic somatomammotropin hormone like 1	Homo sapiens	17-20
2996648-9	1985	The results from CSL indicate that close to the lipid-water interface the DPPC molecule is oriented approximately perpendicular to the bilayer in these low water-content systems.	Water	156-161	chorionic somatomammotropin hormone like 1	Homo sapiens	17-20
3899469-0	1985	Urinary prostaglandin E and antidiuretic hormone during water immersion in man.	Water	56-61	arginine vasopressin	Homo sapiens	28-48
3899469-3	1985	During the diuresis of water immersion a suppression of urinary antidiuretic hormone occurred.	Water	23-28	arginine vasopressin	Homo sapiens	64-84
3931483-6	1985	An alternative explanation of the inhibitory action of colchicine is its ability in the toad urinary bladder to enhance the endogenous synthesis of and sensitivity to prostaglandin E, a potent negative modulator of vasopressin-stimulated water flow.	Water	238-243	arginine vasopressin	Homo sapiens	215-226
4041536-2	1985	Intense motional averaging effects on the 2H nuclear magnetic resonance (NMR) spectrum of 2H2O that occur in aqueous dispersions of dimyristoyl-sn-glycero-3-phosphocholine (Myr2-PtdCho) are explained by a spatial modulation in the orientational order of the water induced by ripplelike structures.	Water	258-263	myosin IC	Homo sapiens	173-177
4068606-9	1985	Vasopressin contributes substantially via increase in systemic vascular resistance to maintain blood pressure during water deprivation.	Water	117-122	arginine vasopressin	Homo sapiens	0-11
2864682-8	1985	ACE inhibition reduces symptoms, enhances exercise capacity, and favorably affects sodium, water, and potassium homeostasis in patients with heart failure.	Water	91-96	angiotensin I converting enzyme	Homo sapiens	0-3
2990759-1	1985	Renal alpha 2-adrenoceptor stimulation by epinephrine infusion reverses cyclic adenosine monophosphate-mediated effects of vasopressin on sodium and water excretion.	Water	149-154	arginine vasopressin	Rattus norvegicus	123-134
2411661-4	1985	In contrast, phenol- and water-extracted, protein-free preparations of LPS (Ph-LPS) markedly inhibited elastase secretion below basal levels in LPS-responsive macrophages.	Water	25-30	toll-like receptor 4	Mus musculus	71-74
2411661-4	1985	In contrast, phenol- and water-extracted, protein-free preparations of LPS (Ph-LPS) markedly inhibited elastase secretion below basal levels in LPS-responsive macrophages.	Water	25-30	toll-like receptor 4	Mus musculus	79-82
4025567-2	1985	Infusion of ANG II into a lateral cerebral ventricle for 5 days (1 or 6 micrograms/h) produced dose-dependent increases in mean arterial pressure associated with increased water intake.	Water	172-177	angiotensinogen	Rattus norvegicus	12-18
4062989-1	1985	H NMR resonances of [cyclo (9----18) Lys1, Gly6]bradykinin (CBK) in (CD3)2SO and H2O solution have been assigned by combined analysis of two-dimensional COSY and NOESY spectra.	Water	81-84	kininogen 1	Homo sapiens	48-58
3894123-2	1985	While insulin treatment restores plasma AA pattern, proline, methionine, valine, isoleucine, and total BCAA remain elevated in skeletal muscle intracellular water.	Water	157-162	insulin	Homo sapiens	6-13
3894123-2	1985	While insulin treatment restores plasma AA pattern, proline, methionine, valine, isoleucine, and total BCAA remain elevated in skeletal muscle intracellular water.	Water	157-162	AT-rich interaction domain 4B	Homo sapiens	103-107
2995443-0	1985	Inhibition of vasopressin-stimulated water flow in toad bladder by phorbol myristate acetate, dioctanoylglycerol, and RHC-80267.	Water	37-42	arginine vasopressin	Homo sapiens	14-25
3899238-5	1985	Collectively the results indicate that although the full development of vasopressin-dependent mechanisms following acute hypotension takes longer when a large proportion of unmyelinated afferent fibres have been destroyed by neonatal treatment with capsaicin, 48 h of water deprivation results in a normal involvement of vasopressin-dependent mechanisms in the maintenance of blood pressure.	Water	268-273	arginine vasopressin	Rattus norvegicus	72-83
2990759-3	1985	In the presence of alpha 1-adrenoceptor blockade with prazosin (30 nM) alpha 2-adrenoceptor stimulation with epinephrine reversed the cyclic adenosine monophosphate-mediated effects of vasopressin on sodium (P less than 0.05) and water (P less than 0.05) excretion.	Water	230-235	arginine vasopressin	Rattus norvegicus	185-196
3894054-1	1985	Freeze-fracture electron microscopy of the toad urinary bladder indicates that distinctive intramembrane particle aggregates are responsible for the increase in apical membrane water permeability that occurs with vasopressin (VP) stimulation.	Water	177-182	arginine vasopressin	Homo sapiens	213-224
3894054-1	1985	Freeze-fracture electron microscopy of the toad urinary bladder indicates that distinctive intramembrane particle aggregates are responsible for the increase in apical membrane water permeability that occurs with vasopressin (VP) stimulation.	Water	177-182	arginine vasopressin	Homo sapiens	226-228
2998894-9	1985	Plasma AVP concentrations of normal subjects (n = 6) after water load (20 ml/kg wt) were clearly reduced from 1.89 +/- 1.00 (before) to 0.42 +/- 0.21 (standing for 60 min) and also from 0.89 +/- 0.41 to 0.40 +/- 0.22 pg/ml (supine for 60 min).	Water	59-64	arginine vasopressin	Homo sapiens	7-10
2863287-0	1985	Importance of amino acids on vasopressin-stimulated water flow.	Water	52-57	arginine vasopressin	Homo sapiens	29-40
2863287-2	1985	We found that histidine, glutamate, and lysine increase vasopressin-stimulated water flow by 75%, 60%, and 43%, respectively.	Water	79-84	arginine vasopressin	Homo sapiens	56-67
2863287-13	1985	Imidazole, similar to histidine, increases vasopressin-stimulated water flow.	Water	66-71	arginine vasopressin	Homo sapiens	43-54
2863287-14	1985	Methylation of histidine on the imidazole ring completely abolished its effectiveness in increasing vasopressin-stimulated water flow.	Water	123-128	arginine vasopressin	Homo sapiens	100-111
3837859-1	1985	The effect of vasoactive intestinal peptide (VIP) on the intake of water was studied in the rat.	Water	67-72	vasoactive intestinal peptide	Rattus norvegicus	14-43
3837859-1	1985	The effect of vasoactive intestinal peptide (VIP) on the intake of water was studied in the rat.	Water	67-72	vasoactive intestinal peptide	Rattus norvegicus	45-48
3837859-2	1985	Intracerebroventricular administration of vasoactive intestinal peptide strongly inhibited drinking in rats deprived of water, but peripheral administration had no effect, indicating that the site of action was central.	Water	120-125	vasoactive intestinal peptide	Rattus norvegicus	42-71
3837859-4	1985	The results indicate that in the rat, vasoactive intestinal peptide may play a role in the control of intake of water as a neuropeptide thirst inhibitor.	Water	112-117	vasoactive intestinal peptide	Rattus norvegicus	38-67
3925891-4	1985	The source of the P aeruginosa, serotype O-11, was found in the water system of the hospital.	Water	64-69	immunoglobulin kappa variable 2-40	Homo sapiens	41-45
2989285-6	1985	Our results strongly suggest that chloride binds to the sixth coordination position of the chlorin iron in myeloperoxidase by replacing the water which is the sixth ligand in the resting state.	Water	140-145	myeloperoxidase	Homo sapiens	107-122
2931621-4	1985	The water intake induced by 0.1 micrograms of AII was significantly suppressed by the simultaneous administration of 2 and 5 micrograms of alpha-hANP.	Water	4-9	angiotensinogen	Rattus norvegicus	46-49
3893156-2	1985	At low doses, ANG II stimulates sodium (Na) and water absorption from all intestinal areas.	Water	48-53	angiotensinogen	Homo sapiens	14-20
3893156-8	1985	ANG II also exerts a dose-dependent dual action on intestinal ion and water absorption in vitro.	Water	70-75	angiotensinogen	Homo sapiens	0-6
3896414-3	1985	In water-sated homozygous Brattleboro rats, in which plasma osmolality and levels of angiotensin II are increased, glucose metabolism in the subfornical organ was 44% higher than in water-sated Long-Evans rats.	Water	3-8	angiotensinogen	Rattus norvegicus	85-99
4005268-6	1985	The beta-sheet content is slightly higher for 5.6 S than 11 S acetylcholinesterase in water.	Water	86-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-82
4080644-2	1985	Drinking behavior stimulated by 48 h water deprivation was inhibited by 2000 ng of pentagastrin which also blocked, at lower doses, water intake induced by icv injection of angiotensin II (100 ng) and carbachol (150 ng).	Water	132-137	angiotensinogen	Rattus norvegicus	173-187
2410986-2	1985	We have previously reported that elevated SP levels, simulating those reported in patients with carcinoid syndrome, induce profound changes in intestinal water and electrolyte secretion, motility, and blood flow in a canine model.	Water	154-159	tachykinin precursor 1	Homo sapiens	42-44
2410986-9	1985	During SP infusion there was a significant secretory response of water (-48 +/- 12 microliters/min), Na+ (-7.7 +/- 2.5 microEq/min), Cl- (-8.8 +/- 2.7 microEq/min) and K+ (-0.57 +/- 0.14 microEq/min), and hypermotility (motility index: 1479 +/- 138 mm2/5 min).	Water	65-70	tachykinin precursor 1	Homo sapiens	7-9
4080644-2	1985	Drinking behavior stimulated by 48 h water deprivation was inhibited by 2000 ng of pentagastrin which also blocked, at lower doses, water intake induced by icv injection of angiotensin II (100 ng) and carbachol (150 ng).	Water	37-42	angiotensinogen	Rattus norvegicus	173-187
2988346-1	1985	Alpha 2-adrenoceptor agonists attenuate vasopressin-mediated changes in water excretion.	Water	72-77	arginine vasopressin	Rattus norvegicus	40-51
2988634-1	1985	Apolipoprotein A-I/phosphatidylcholine/cholesterol complexes formed in a 2-chloroethanol-water mixture.	Water	89-94	apolipoprotein A1	Homo sapiens	0-18
2988634-2	1985	Apolipoprotein A-I can spontaneously associate with phosphatidylcholine and cholesterol in 2-chloroethanol-water mixture.	Water	107-112	apolipoprotein A1	Homo sapiens	0-18
2412515-8	1985	It is concluded that norepinephrine and vasopressin are important stimulators of the urinary kallikrein excretion only in those circumstances where it is necessary to eliminate an excess of water.	Water	190-195	arginine vasopressin	Rattus norvegicus	40-51
4010780-1	1985	It has been suggested that arginine vasopressin (AVP) is involved in the retention of learned responses, in addition to its classical physiological functions of water retention and modulation of blood pressure.	Water	161-166	arginine vasopressin	Homo sapiens	36-47
4010780-1	1985	It has been suggested that arginine vasopressin (AVP) is involved in the retention of learned responses, in addition to its classical physiological functions of water retention and modulation of blood pressure.	Water	161-166	arginine vasopressin	Homo sapiens	49-52
2988346-5	1985	Vasopressin (10 microU/ml) produced a significant (P less than 0.05) decrease in both water and sodium excretion.	Water	86-91	arginine vasopressin	Rattus norvegicus	0-11
2988346-7	1985	Alpha 2-Adrenoceptor stimulation with l-epinephrine (28 nM) reversed (P less than 0.05) the effects of vasopressin on water and sodium excretion.	Water	118-123	arginine vasopressin	Rattus norvegicus	103-114
2988346-11	1985	Thus alpha 2-adrenoceptor stimulation antagonized the effects of vasopressin on both water and sodium excretion at the renal level.	Water	85-90	arginine vasopressin	Rattus norvegicus	65-76
3887946-4	1985	Micropuncture and microperfusion studies have demonstrated that proximal tubular sodium and water transport are stimulated by physiological concentrations (10(-12) to 10(-10) M) of ANG II on the peritubular side, whereas higher doses (10(-7) M) cause inhibition.	Water	92-97	angiotensinogen	Homo sapiens	181-187
3900253-3	1985	Regulation of water and sodium metabolism: urine-concentrating mechanisms and action of vasopressin].	Water	14-19	arginine vasopressin	Homo sapiens	88-99
3892648-4	1985	The AVP levels were the same in groups I and II, but higher in group I than III both before and after water deprivation.	Water	102-107	arginine vasopressin	Homo sapiens	4-7
3892648-5	1985	In group II, AVP was higher than in group III only after water deprivation; V was significantly reduced in all groups.	Water	57-62	arginine vasopressin	Homo sapiens	13-16
2485266-0	1985	Interactions between neural mechanisms, the renin-angiotensin system and vasopressin in the maintenance of blood pressure during water deprivation: studies in Long Evans and Brattleboro rats.	Water	129-134	arginine vasopressin	Rattus norvegicus	73-84
4007798-5	1985	However, gonadal and reproductive tract tissue weights were markedly reduced and food and water consumption were significantly elevated in PRL-treated birds.	Water	90-95	prolactin	Homo sapiens	139-142
3858854-2	1985	NPY (24, 78, 235, 783, and 2351 pmol/0.3 mul) produced a large, dose-dependent increase in food intake as well as small increase in water intake.	Water	132-137	neuropeptide Y	Rattus norvegicus	0-3
3884242-0	1985	Renin-aldosterone system suppression during water immersion in renovascular hypertension.	Water	44-49	renin	Homo sapiens	0-5
3884242-2	1985	Water immersion significantly suppressed the high peripheral renin levels of the patients despite an autonomic renin secretion from the stenotic kidney, a significant reduction of mean blood pressure and an increase in distal tubule sodium concentration.	Water	0-5	renin	Homo sapiens	61-66
4011400-6	1985	Administration of exogenous vasopressin in water loaded animals caused a similar rise in urine osmolality.	Water	43-48	arginine vasopressin	Rattus norvegicus	28-39
4021228-0	1985	Dopaminergic modulation of the renal effect of arginine-vasopressin in water-loaded rats.	Water	71-76	arginine vasopressin	Rattus norvegicus	56-67
2984947-1	1985	Acidification of the medium bathing the serosal surface of the toad urinary bladder results in impairment of the water permeability response to vasopressin.	Water	113-118	arginine vasopressin	Homo sapiens	144-155
2984947-3	1985	The disulfonic stilbenes SITS and DIDS and the diuretic furosemide, agents known to interfere with anion transport and with the regulation of intracellular pH in other tissues, inhibited the water flow response to vasopressin and C1PhS-cAMP in a pH-dependent manner when added to the serosal bathing medium.	Water	191-196	arginine vasopressin	Homo sapiens	214-225
2984947-7	1985	These results are consistent with the view that changes in intracellular hydrogen ion and/or anion concentration can selectively inhibit the increase in water permeability elicited by vasopressin at a step(s) distal to the generation of cAMP.	Water	153-158	arginine vasopressin	Homo sapiens	184-195
4031387-4	1985	Physiological studies performed with this method demonstrated that AVP becomes undetectable after water loading 20 ml per Kg of water po; (N = 6) and increases in response to hypertonic saline infusion (0.05 ml/kg/min; N = 15) with a linear relationship between plasma osmolality and AVP in individual subjects; this relationship is maintained when the test is repeated in the same subjects.	Water	98-103	arginine vasopressin	Homo sapiens	67-70
4031387-4	1985	Physiological studies performed with this method demonstrated that AVP becomes undetectable after water loading 20 ml per Kg of water po; (N = 6) and increases in response to hypertonic saline infusion (0.05 ml/kg/min; N = 15) with a linear relationship between plasma osmolality and AVP in individual subjects; this relationship is maintained when the test is repeated in the same subjects.	Water	128-133	arginine vasopressin	Homo sapiens	67-70
3998146-7	1985	When water-deprived saralasin-treated rats were given a specific antagonist to the vascular action of arginine vasopressin (AVP), d(CH2)5Tyr(Me)AVP, a fall in systemic blood pressure occurred, on average from 102 +/- 5 to 80 +/- 5 mmHg, unaccompanied by dilation of renal arterioles, so that both plasma flow rate (129 +/- 8 vs. 85 +/- 13 nl/min) and SNGFR (31.0 +/- 2.9 vs. 18.2 +/- 4.4 nl/min) decreased.	Water	5-10	arginine vasopressin	Rattus norvegicus	102-122
3998146-7	1985	When water-deprived saralasin-treated rats were given a specific antagonist to the vascular action of arginine vasopressin (AVP), d(CH2)5Tyr(Me)AVP, a fall in systemic blood pressure occurred, on average from 102 +/- 5 to 80 +/- 5 mmHg, unaccompanied by dilation of renal arterioles, so that both plasma flow rate (129 +/- 8 vs. 85 +/- 13 nl/min) and SNGFR (31.0 +/- 2.9 vs. 18.2 +/- 4.4 nl/min) decreased.	Water	5-10	arginine vasopressin	Rattus norvegicus	124-127
3998146-7	1985	When water-deprived saralasin-treated rats were given a specific antagonist to the vascular action of arginine vasopressin (AVP), d(CH2)5Tyr(Me)AVP, a fall in systemic blood pressure occurred, on average from 102 +/- 5 to 80 +/- 5 mmHg, unaccompanied by dilation of renal arterioles, so that both plasma flow rate (129 +/- 8 vs. 85 +/- 13 nl/min) and SNGFR (31.0 +/- 2.9 vs. 18.2 +/- 4.4 nl/min) decreased.	Water	5-10	arginine vasopressin	Rattus norvegicus	144-147
3998146-9	1985	In water-diuretic rats, administration of a moderately pressor dose of AVP (4 mU/kg per min) resulted in a significant rise in kidney blood flow rate (from 8.8 +/- 1.2 to 9.6 +/- 1.3 ml/min).	Water	3-8	arginine vasopressin	Rattus norvegicus	71-74
2859512-0	1985	Effect of a selective octapeptide analogue of somatostatin on renal water excretion in the dog.	Water	68-73	somatostatin	Canis lupus familiaris	46-58
2859512-1	1985	Somatostatin produces a modest water diuresis in dogs by inhibiting the renal tubular action of ADH.	Water	31-36	somatostatin	Canis lupus familiaris	0-12
3867447-0	1985	[Acetylcholinesterase activity in the mixed saliva of subjects living in areas of differing fluoride content in the drinking water].	Water	125-130	acetylcholinesterase (Cartwright blood group)	Homo sapiens	1-21
3989425-4	1985	Significantly fewer neurones showed phasic activity in DI rats which had been pretreated with vasopressin tannate at a dose which significantly reduced urine volume, water intake and plasma osmolality.	Water	166-171	arginine vasopressin	Rattus norvegicus	94-105
3989425-7	1985	Hypo-osmotic stimulation, induced by an intragastric injection of 10 ml tap water, reduced the discharge rate of each of four neurones from DI rats by 50% or more.	Water	76-81	nuclear RNA export factor 1	Rattus norvegicus	72-75
2582214-6	1985	In fact, it has been shown that there is a significant transient increase in IFN plasma level 2 hours after a fat-rich meal or drinking 700 ml of water.	Water	146-151	interferon alpha 1	Homo sapiens	77-80
2992118-1	1985	PGE2 inhibited 10 m U/ml vasopressin-induced osmotic water flow of the toad bladder at 2 X 10(-8) M. PGE2 suppressed vasopressin-mediated cyclic AMP accumulation in epithelial cells and also vasopressin-mediated adenylate cyclase activity in a crude homogenate of the cells.	Water	53-58	arginine vasopressin	Homo sapiens	25-36
2992118-3	1985	These findings indicate that PGE2 inhibits vasopressin-induced water flow mainly through suppression of adenylate cyclase activity, and that the role of PGE2 at that point in the reaction leading to increased water permeability following cyclic AMP production may be slight.	Water	63-68	arginine vasopressin	Homo sapiens	43-54
3977441-0	1985	The effect of vasopressin on solute and water excretion during and after surgical operations.	Water	40-45	arginine vasopressin	Homo sapiens	14-25
2579567-1	1985	Receptor occupation by a variety of Ca2+-mobilizing hormones, such as alpha 1-adrenergic agents, vasopressin and angiotensin II, causes a rapid phosphodiesterase-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate in the plasma membrane with the production of the water soluble compound myo-inositol-1,4,5-trisphosphate (IP3) and the lipophilic molecule 1,2-diacylglycerol (DG).	Water	273-278	arginine vasopressin	Homo sapiens	97-108
2579567-1	1985	Receptor occupation by a variety of Ca2+-mobilizing hormones, such as alpha 1-adrenergic agents, vasopressin and angiotensin II, causes a rapid phosphodiesterase-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate in the plasma membrane with the production of the water soluble compound myo-inositol-1,4,5-trisphosphate (IP3) and the lipophilic molecule 1,2-diacylglycerol (DG).	Water	273-278	angiotensinogen	Homo sapiens	113-127
3157876-3	1985	3 days of water deprivation resulted in elevated plasma AVP levels (36.1 +/- 4.7 pg AVP/ml) which were significantly reduced following intravenous infusion of 0.02 (21.4 +/- 3.6), 0.2 (15.6 +/- 1.6), and 2.0 (13.9 +/- 3.8) nmol Atriopeptin III.	Water	10-15	arginine vasopressin	Rattus norvegicus	56-59
3156600-7	1985	In our calculations we have taken into account that the reactions catalyzed by lactate dehydrogenase and alcohol dehydrogenase are reversible and that lactate or ethanol labelled during the metabolism of the other tritiated substrates will contribute to the tritium found in water.	Water	275-280	aldo-keto reductase family 1 member A1	Rattus norvegicus	105-126
3971518-8	1985	Water intake was significantly increased on the 3rd, 4th, and 5th days of angiotensin II infusion only in rats with lesions in the subfornical organ.	Water	0-5	angiotensinogen	Rattus norvegicus	74-88
3882561-2	1985	The phenol-water-extracted LPS from B. gingivalis 381 was composed of 46% carbohydrate, 23% hexosamine, 18% fatty acid, and 5% protein.	Water	11-16	toll-like receptor 4	Mus musculus	27-30
3882561-5	1985	The butanol-water-extracted LPS from this strain was composed of 76% glucose, 7% fatty acid, and 13% protein, and it was associated with a number of polypeptides (13 to 56 kilodaltons).	Water	12-17	toll-like receptor 4	Mus musculus	28-31
3882561-8	1985	Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli.	Water	112-117	toll-like receptor 4	Mus musculus	13-16
3882561-8	1985	Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli.	Water	112-117	toll-like receptor 4	Mus musculus	128-131
3882561-8	1985	Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli.	Water	112-117	toll-like receptor 4	Mus musculus	128-131
3882561-8	1985	Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli.	Water	112-117	toll-like receptor 4	Mus musculus	128-131
3882561-8	1985	Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli.	Water	144-149	toll-like receptor 4	Mus musculus	13-16
3882561-8	1985	Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli.	Water	144-149	toll-like receptor 4	Mus musculus	13-16
4009446-4	1985	There was a 51.4% decrease in the hepatic cytochrome P-450 content in water-deprived rats.	Water	70-75	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	42-58
3846709-0	1985	Independent action of prostaglandins and kinins on vasopressin-stimulated water flow.	Water	74-79	arginine vasopressin	Homo sapiens	51-62
3846709-5	1985	Inhibition of kallikrein by aprotinin caused vasopressin-stimulated water flow to increase further (24.8 +/- 4.9 to 34.5 +/- 4.8 microliters/min) while potentiation of kinins by captropril caused vasopressin-stimulated water flow to decrease (45 +/- 6.3 to 30.5 +/- 5.4 microliters/min).	Water	68-73	arginine vasopressin	Homo sapiens	45-56
3846709-5	1985	Inhibition of kallikrein by aprotinin caused vasopressin-stimulated water flow to increase further (24.8 +/- 4.9 to 34.5 +/- 4.8 microliters/min) while potentiation of kinins by captropril caused vasopressin-stimulated water flow to decrease (45 +/- 6.3 to 30.5 +/- 5.4 microliters/min).	Water	219-224	arginine vasopressin	Homo sapiens	45-56
3156600-5	1985	The model allows estimation of the ethanol oxidation rate by the non-alcohol dehydrogenase pathways from the relative yield of tritium in water and glucose.	Water	138-143	aldo-keto reductase family 1 member A1	Rattus norvegicus	69-90
17007768-1	1985	The solvophobic theory developed earlier by Sinanoglu introducing the use of molecular surface areas and microthermodynamic surface and interfacial tensions at molecular dimensions is applied to the interpretation of calorimetric data on denaturation of lysozyme in a wide range of methanol/water mixtures.	Water	291-296	lysozyme	Homo sapiens	254-262
3846709-7	1985	The addition of prostaglandin E2 caused vasopressin-stimulated water flow to decrease (17.5 +/- 2.7 to 5.71 +/- 1.0 microliter/min) while the inhibition of endogenous prostaglandins caused vasopressin-stimulated water flow to increase (26.7 +/- 3.4 to 39.2 +/- 3.5 microliters/min).	Water	63-68	arginine vasopressin	Homo sapiens	40-51
3846709-7	1985	The addition of prostaglandin E2 caused vasopressin-stimulated water flow to decrease (17.5 +/- 2.7 to 5.71 +/- 1.0 microliter/min) while the inhibition of endogenous prostaglandins caused vasopressin-stimulated water flow to increase (26.7 +/- 3.4 to 39.2 +/- 3.5 microliters/min).	Water	212-217	arginine vasopressin	Homo sapiens	40-51
3846709-8	1985	Thus, the inhibitory effects of prostaglandins and kinins on vasopressin-stimulated water flow are independent of one another.	Water	84-89	arginine vasopressin	Homo sapiens	61-72
3872988-4	1985	In seven capillaries the addition of bovine serum albumin (BSA) to the perfusate at concentrations of 1 and 10 mg ml-1 increased sigma delta II from a mean value of 7.14 +/- 1.81 cm H2O to one of 18.71 +/- 2.33 cm H2O and at the same time halved Lp.	Water	182-185	albumin	Homo sapiens	44-57
3872988-4	1985	In seven capillaries the addition of bovine serum albumin (BSA) to the perfusate at concentrations of 1 and 10 mg ml-1 increased sigma delta II from a mean value of 7.14 +/- 1.81 cm H2O to one of 18.71 +/- 2.33 cm H2O and at the same time halved Lp.	Water	214-217	albumin	Homo sapiens	44-57
3157876-3	1985	3 days of water deprivation resulted in elevated plasma AVP levels (36.1 +/- 4.7 pg AVP/ml) which were significantly reduced following intravenous infusion of 0.02 (21.4 +/- 3.6), 0.2 (15.6 +/- 1.6), and 2.0 (13.9 +/- 3.8) nmol Atriopeptin III.	Water	10-15	arginine vasopressin	Rattus norvegicus	84-87
2982284-0	1985	Water deprivation upregulates angiotensin II receptors in rat anterior pituitary.	Water	0-5	angiotensinogen	Rattus norvegicus	30-44
3965617-1	1985	Dopamine-beta-hydroxylase (DBH) in membrane-bound (mDBH) and water-soluble (sDBH) forms was isolated from chromaffin granules of bovine adrenal medullae and a human pheochromocytoma tumor.	Water	61-66	dopamine beta-hydroxylase	Bos taurus	0-25
3918461-5	1985	The addition of a very low dose of antidiuretic hormone (ADH) (0.125 mU/ml) during prostaglandin synthesis inhibition increased luminal membrane water permeability to the same level as maximal stimulation with ADH, while tissue water permeability failed to increase proportionately.	Water	145-150	arginine vasopressin	Homo sapiens	35-55
3918461-5	1985	The addition of a very low dose of antidiuretic hormone (ADH) (0.125 mU/ml) during prostaglandin synthesis inhibition increased luminal membrane water permeability to the same level as maximal stimulation with ADH, while tissue water permeability failed to increase proportionately.	Water	145-150	arginine vasopressin	Homo sapiens	57-60
3918461-5	1985	The addition of a very low dose of antidiuretic hormone (ADH) (0.125 mU/ml) during prostaglandin synthesis inhibition increased luminal membrane water permeability to the same level as maximal stimulation with ADH, while tissue water permeability failed to increase proportionately.	Water	228-233	arginine vasopressin	Homo sapiens	35-55
3918461-5	1985	The addition of a very low dose of antidiuretic hormone (ADH) (0.125 mU/ml) during prostaglandin synthesis inhibition increased luminal membrane water permeability to the same level as maximal stimulation with ADH, while tissue water permeability failed to increase proportionately.	Water	228-233	arginine vasopressin	Homo sapiens	57-60
3918461-6	1985	The results imply the presence of a regulatable barrier to water movement across toad bladder that is distal to the luminal membrane and subject to control by either prostaglandins or ADH.	Water	59-64	arginine vasopressin	Homo sapiens	184-187
2860030-0	1985	Plasma arginine vasopressin response to water load during labor.	Water	40-45	arginine vasopressin	Homo sapiens	16-27
2860030-1	1985	To find out whether plasma vasopressin (PAVP) response to a water load during pregnancy is inappropriately high, as had been speculated, we measured PAVP by radioimmunoassay in 30 women at the time of delivery.	Water	60-65	arginine vasopressin	Homo sapiens	27-38
3965617-1	1985	Dopamine-beta-hydroxylase (DBH) in membrane-bound (mDBH) and water-soluble (sDBH) forms was isolated from chromaffin granules of bovine adrenal medullae and a human pheochromocytoma tumor.	Water	61-66	dopamine beta-hydroxylase	Bos taurus	27-30
3999047-1	1985	In adrenalectomized, deoxycorticosterone-treated and normal rats, injection of angiotensin II through a cannula implanted in the preoptic region caused increased intakes of hypertonic NaCl and water when both fluids were available, whereas injection of carbachol through the same cannula only caused increased water intake.	Water	193-198	angiotensinogen	Rattus norvegicus	79-93
24896988-2	1985	The rats were then tested for the aversion of tap water in compound with the illness-paired odor offered together with an alternative new odor not paired with toxicosis.	Water	50-55	nuclear RNA export factor 1	Rattus norvegicus	46-49
3999047-1	1985	In adrenalectomized, deoxycorticosterone-treated and normal rats, injection of angiotensin II through a cannula implanted in the preoptic region caused increased intakes of hypertonic NaCl and water when both fluids were available, whereas injection of carbachol through the same cannula only caused increased water intake.	Water	310-315	angiotensinogen	Rattus norvegicus	79-93
3991418-0	1985	The relationship between plasma concentrations of prolactin and consumption of feed and water during the reproductive cycle of the domestic turkey.	Water	88-93	prolactin	Meleagris gallopavo	50-59
3991418-11	1985	These data suggest that the changes in the concentration of PRL may be related to the large changes in intermediary and water metabolism that occur during broodiness.	Water	120-125	prolactin	Meleagris gallopavo	60-63
4038437-0	1985	Microfilaments and the effects of antidiuretic hormone on water permeability.	Water	58-63	arginine vasopressin	Homo sapiens	34-54
2867770-2	1985	Lower plasma levels of SASP and 5-ASA as compared to those of SP may be due to different absorption rates from the colon because of different pK values and pH dependent lipid-water partition coefficients.	Water	175-180	aspartic peptidase retroviral like 1	Homo sapiens	23-27
2939904-0	1985	Role of the cytoskeleton in the control of transcellular water flow by vasopressin in amphibian urinary bladder.	Water	57-62	arginine vasopressin	Homo sapiens	71-82
2939907-0	1985	Cell determinants of vasopressin-stimulated water flow.	Water	44-49	arginine vasopressin	Homo sapiens	21-32
2939907-5	1985	Using this technique, I found that the effect of the prostaglandin inhibitor Naproxen to increase vasopressin-stimulated water flow is due to increased luminal membrane permeability.	Water	121-126	arginine vasopressin	Homo sapiens	98-109
3846407-5	1985	The infusion of vasopressin induced significant increases in circulating levels of vasopressin (248.1 +/- 35.2 pg/ml in vasopressin-infused rats (n = 7) compared to 95.5 +/- 14.6 pg/ml in vehicle-infused rats (n = 7), p less than 0.001) and in weight gain (39.6 +/- 1.3 g in vasopressin-infused rats (n = 7) compared to 29.1 +/- 3.3 g in vehicle-infused rats (n = 7), p less than 0.05), and also sustained decreases in water intake and urine volume, but it did not induce any change in urinary sodium excretion.	Water	419-424	arginine vasopressin	Rattus norvegicus	16-27
3846407-5	1985	The infusion of vasopressin induced significant increases in circulating levels of vasopressin (248.1 +/- 35.2 pg/ml in vasopressin-infused rats (n = 7) compared to 95.5 +/- 14.6 pg/ml in vehicle-infused rats (n = 7), p less than 0.001) and in weight gain (39.6 +/- 1.3 g in vasopressin-infused rats (n = 7) compared to 29.1 +/- 3.3 g in vehicle-infused rats (n = 7), p less than 0.05), and also sustained decreases in water intake and urine volume, but it did not induce any change in urinary sodium excretion.	Water	419-424	arginine vasopressin	Rattus norvegicus	83-94
3846407-5	1985	The infusion of vasopressin induced significant increases in circulating levels of vasopressin (248.1 +/- 35.2 pg/ml in vasopressin-infused rats (n = 7) compared to 95.5 +/- 14.6 pg/ml in vehicle-infused rats (n = 7), p less than 0.001) and in weight gain (39.6 +/- 1.3 g in vasopressin-infused rats (n = 7) compared to 29.1 +/- 3.3 g in vehicle-infused rats (n = 7), p less than 0.05), and also sustained decreases in water intake and urine volume, but it did not induce any change in urinary sodium excretion.	Water	419-424	arginine vasopressin	Rattus norvegicus	83-94
3846407-5	1985	The infusion of vasopressin induced significant increases in circulating levels of vasopressin (248.1 +/- 35.2 pg/ml in vasopressin-infused rats (n = 7) compared to 95.5 +/- 14.6 pg/ml in vehicle-infused rats (n = 7), p less than 0.001) and in weight gain (39.6 +/- 1.3 g in vasopressin-infused rats (n = 7) compared to 29.1 +/- 3.3 g in vehicle-infused rats (n = 7), p less than 0.05), and also sustained decreases in water intake and urine volume, but it did not induce any change in urinary sodium excretion.	Water	419-424	arginine vasopressin	Rattus norvegicus	83-94
3155943-2	1985	Water-soluble and membrane-bound calmodulin-binding polypeptides formed upon limited proteolysis of erythrocyte ghosts were isolated by means of affinity chromatography.	Water	0-5	calmodulin 1	Homo sapiens	33-43
2981464-1	1985	The renin-angiotension system is activated in many patients with congestive heart failure (CHF), resulting in angiotensin-mediated vasoconstriction and aldosterone-mediated sodium and water retention.	Water	184-189	renin	Homo sapiens	4-9
4013833-5	1985	Plasma vasopressin (AVP) during water deprivation was significantly lower in the DI group than in the controls (4.2 +/- 0.5 vs. 10.6 +/- 1.7 ng/l) (p less than 0.01), the difference being more pronounced in the high osmolality range (4.8 +/- 0.7 vs. 14.4 +/- 3.1 ng/l) (p less than 0.01).	Water	32-37	arginine vasopressin	Homo sapiens	7-18
4026920-1	1985	Female albino rats were treated with sodium salicylate dissolved in tap water orally by intubation.	Water	72-77	nuclear RNA export factor 1	Rattus norvegicus	68-71
3011158-4	1985	The effects obtained with A23187 suggest that calcium ions modulate vasopressin-induced osmotic water flow by interfering with a pre-cAMP step.	Water	96-101	arginine vasopressin	Homo sapiens	68-79
3011158-9	1985	Furthermore, the inhibition of prostaglandin biosynthesis by hydrocortisone (a phospholipase inhibitor) or by indomethacin and naproxen (agents that inhibit arachidonic acid oxygenase) results in augmented vasopressin-stimulated water flow and prevents the inhibitory effect of the ionophore.	Water	229-234	arginine vasopressin	Homo sapiens	206-217
2939907-6	1985	The effect of histidine to increase vasopressin-stimulated water flow, however, depends on increased permeability of both the luminal membrane as well as the underlying structures.	Water	59-64	arginine vasopressin	Homo sapiens	36-47
2865998-11	1985	It appears that angiotensin II is involved in salt intake, as well as in producing preference for sweet taste and water.	Water	114-119	angiotensinogen	Rattus norvegicus	16-30
3967068-1	1985	A study was made of 3H-leucine incorporation into water- and tween-soluble proteins of the hippocampal CA3 field under the development of prolonged post-tetanic potentiation (PPTP) because of stimulation of mossy fibers.	Water	50-55	carbonic anhydrase 3	Homo sapiens	103-106
2998520-4	1985	The present study was designed to investigate the possible interaction between cholinergic and adrenergic neurons of the subfornical organ and the effect of angiotensin II and carbachol in the regulation of water intake by this structure.	Water	207-212	angiotensinogen	Rattus norvegicus	157-171
2998520-7	1985	Injection of 0.1 to 4.0 ng angiotensin II into the SFO caused a dose-dependent increase in water intake.	Water	91-96	angiotensinogen	Rattus norvegicus	27-41
4075543-3	1985	Fluid consumption in animals drinking tap water was constant at between 35-40 ml/day throughout the six-month study period.	Water	42-47	nuclear RNA export factor 1	Rattus norvegicus	38-41
3918602-0	1985	PCB congener analysis of water and caddisfly larvae (Insecta:Trichoptera) in the upper Hudson River by glass capillary chromatography.	Water	25-30	pyruvate carboxylase	Homo sapiens	0-3
2988827-4	1985	ACTH increased water consumption, Na+ and K+ excretion and creatinine clearance by the 4th day of infusion and these effects were not significantly altered when adrenaline was also infused.	Water	15-20	proopiomelanocortin	Canis lupus familiaris	0-4
3922622-2	1985	Antidiuretic hormone (ADH) causes the appearance of water-conducting particle aggregates in the luminal membrane of receptor cells in amphibian bladder and skin, and in the mammalian collecting duct.	Water	52-57	arginine vasopressin	Homo sapiens	0-26
3995558-2	1985	After water deprivation for two days, control rats displayed characteristic antidiuretic response including a 75% reduction of urinary excretion and a six-fold decrease in vasopressin content of the neural lobe associated with a dramatic depletion of neurosecretory granules in corresponding axons.	Water	6-11	arginine vasopressin	Rattus norvegicus	172-183
4018059-0	1985	Central venous pressure and plasma arginine vasopressin during water immersion in man.	Water	63-68	arginine vasopressin	Homo sapiens	44-55
2412098-0	1985	Modulation of vasopressin-induced water permeability of the cortical collecting tubule by endogenous and exogenous prostaglandins.	Water	34-39	arginine vasopressin	Homo sapiens	14-25
3875509-1	1985	Plasma lipoproteins containing apolipoproteins B and E, as well as delipidated water-soluble apoE, suppress lymphocyte activation by polyclonal T cell mitogens in vitro.	Water	79-84	apolipoprotein E	Homo sapiens	93-97
2995193-1	1985	Phenothiazines and W7, calmodulin antagonists, inhibit the water flow response produced by ADH, exogenous cyclic AMP, phosphodiesterase inhibition and serosal hypertonicity.	Water	59-64	calmodulin 1	Homo sapiens	23-33
3997320-2	1985	A water-soluble hydrocortisone complex also inhibited lysozyme release, but at high concentrations, lysis of the cells occurred.	Water	2-7	lysozyme	Homo sapiens	54-62
3007763-11	1985	Together, these results demonstrate purinergic modulation of basal and arginine vasopressin-stimulated water flux in the mammalian collecting tubule.	Water	103-108	arginine vasopressin	Homo sapiens	80-91
2981734-4	1985	These promise to be equally useful for assessing the importance of VP in limiting water excretion under a variety of circumstances.	Water	82-87	arginine vasopressin	Homo sapiens	67-69
3930753-3	1985	As previously observed for net water fluxes, the increase in the unidirectional water movement induced by ADH was well preserved by glutaraldehyde fixation.	Water	31-36	arginine vasopressin	Homo sapiens	106-109
3930753-3	1985	As previously observed for net water fluxes, the increase in the unidirectional water movement induced by ADH was well preserved by glutaraldehyde fixation.	Water	80-85	arginine vasopressin	Homo sapiens	106-109
2412098-1	1985	These experiments were designed to test the thesis that prostaglandins produced by the cortical collecting tubule cells could modulate the vasopressin-induced osmotic water permeability (Pf).	Water	167-172	arginine vasopressin	Homo sapiens	139-150
4094570-2	1985	The LPS which was extracted by the phenol-water method and dialyzed against tap water to remove phenol showed ribbon-like structures, and it formed a hexagonal lattice structure with a lattice constant of 14.5 +/- 0.3 nm when it was precipitated by addition of two volumes of 10 mM MgCl2-ethanol.	Water	80-85	SEC14 like lipid binding 2	Homo sapiens	76-79
4039825-4	1985	Exposure of the male rats to different novel situations such as being placed in a new cage, being placed on a platform in water, or being handled resulted in increased prolactin levels.	Water	122-127	prolactin	Rattus norvegicus	168-177
4047982-2	1985	The neuropeptide vasopressin is nowadays recognized as a putative neurotransmitter, after years of study on its neurosecretory hormonal aspect in water metabolism.	Water	146-151	arginine vasopressin	Rattus norvegicus	17-28
2997891-3	1985	This inhibitory effect of TFP on the ADH-stimulated osmotic water flow persisted in the presence of naproxen (10(-5) M), a known inhibitor of prostaglandin synthesis.	Water	60-65	arginine vasopressin	Homo sapiens	37-40
6532565-0	1984	Evidence that the zymogen of phospholipase A2 binds to a negatively charged lipid-water interface.	Water	82-87	phospholipase A2 group IB	Homo sapiens	29-45
6549039-2	1984	Neuropeptide Y (24 and 78 pmoles/0.3 microliter isotonic saline) caused a dose-dependent increase in food intake, as well as a small, dose-dependent increase in water intake.	Water	161-166	neuropeptide Y	Rattus norvegicus	0-14
6441599-7	1984	Semisynthetic porcine phospholipase A2 analogues in which the position of the alpha-NH3+ group is varied have lost their affinity toward neutral lipid-water interfaces and consequently their catalytic activity on micellar substrates.	Water	151-156	phospholipase A2	Equus caballus	22-38
6441599-9	1984	Substitution of the side chain of Ala1 in porcine phospholipase A2 by hydrophobic side chains abolishes almost all activity due to the loss of affinity for neutral lipid-water interfaces.	Water	170-175	phospholipase A2	Equus caballus	50-66
6532565-1	1984	Evidence is presented that the zymogen of porcine pancreatic phospholipase A2 (prophospholipase A2) interacts with a lipid-water interface provided that the interface has a net negative surface charge.	Water	123-128	phospholipase A2 group IB	Homo sapiens	61-77
6334079-13	1984	C4BP also bound C4(H2O) (the product resulting from spontaneous hydrolysis of the thiol ester bond in native C4) and weakly bound C4c, but had no measurable affinity for native C4 or C4d at physiological ionic strength.	Water	19-22	complement component 4 binding protein alpha	Homo sapiens	0-4
6514445-4	1984	Both histamine and CCK increased the intracholecystic pressure at the 50% resting volume from 12.4 cm H2O to 18.9 and 15.5 cm H2O, respectively.	Water	102-105	cholecystokinin	Homo sapiens	19-22
6093565-1	1984	Adenosine 3",5"-cyclic monophosphate (cAMP) is believed to mediate the transport of ions, water, and mucous glycoproteins in the respiratory tract.	Water	90-95	cathelicidin antimicrobial peptide	Canis lupus familiaris	38-42
6391606-1	1984	Single intracranial injections of the peptide analogues of angiotensin and the enzyme renin induced drinking of water and 1.8% NaCl solution in prepubertal female pigs maintained ad libitum on a sodium-free diet with unrestricted access to both fluids.	Water	112-117	renin	Sus scrofa	86-91
6391606-6	1984	Single microinjections of 1 and 10 mU of renin also elicited dose-dependent drinking of water and 1.8% NaCl, but compared with the peptide analogues of angiotensin the responses had a longer latency and duration and were more variable between individual animals.	Water	88-93	renin	Sus scrofa	41-46
6152135-1	1984	Tyrosine hydroxylase can be measured by release of tritiated water from labeled tyrosine, and the assay method has now been modified to allow recovery of 3H2O from the reaction mixture in a much more rapid and less tedious manner than previously possible.	Water	61-66	tyrosine hydroxylase	Homo sapiens	0-20
6514445-4	1984	Both histamine and CCK increased the intracholecystic pressure at the 50% resting volume from 12.4 cm H2O to 18.9 and 15.5 cm H2O, respectively.	Water	126-129	cholecystokinin	Homo sapiens	19-22
6434116-7	1984	These results support the hypothesis that the polyuria with increased free water clearance and the natriuresis occurring during sustained tachycardia in man are due to inhibition of secretion of vasopressin and the release of natriuretic factor.	Water	75-80	arginine vasopressin	Homo sapiens	195-206
6541283-6	1984	ADX rats showed a consistently greater PRL response to being placed on a platform above water (novel environment) or when receiving intermittant footshock than did ADX+CORT rats.	Water	88-93	prolactin	Rattus norvegicus	39-42
6522821-2	1984	During this period they were carefully monitored and lost 100 kg in bodyweight, principally accounted for by cumulative losses of water in milk, urine, faeces and respired air.	Water	130-135	Weaning weight-maternal milk	Bos taurus	139-143
6441924-3	1984	Trifluoperazine, a drug which inhibits the Ca2+-calmodulin complex, selectively inhibits vasopressin-induced water transport.	Water	109-114	arginine vasopressin	Homo sapiens	89-100
6098765-2	1984	In situ incubation of IMCT with 10(-7) M arginine vasopressin (AVP) at 300 mOsm/kg H2O in control normokalemic rats increased cyclic AMP content (fmoles/mm) from 5.68 +/- 1.41 to 30.3 +/- 5.31 (P less than 0.001).	Water	83-86	arginine vasopressin	Rattus norvegicus	63-66
6497818-5	1984	In the dog, Ppl became more negative in the upper and middle thoracic regions with +Gz stress (-1.63 and -1.66 cm H2O.G-1, respectively), but, in the lower thorax, Ppl increased slightly (0.05 cm H2O.G-1).	Water	114-117	periplakin	Canis lupus familiaris	12-15
6497818-5	1984	In the dog, Ppl became more negative in the upper and middle thoracic regions with +Gz stress (-1.63 and -1.66 cm H2O.G-1, respectively), but, in the lower thorax, Ppl increased slightly (0.05 cm H2O.G-1).	Water	196-199	periplakin	Canis lupus familiaris	12-15
6497818-5	1984	In the dog, Ppl became more negative in the upper and middle thoracic regions with +Gz stress (-1.63 and -1.66 cm H2O.G-1, respectively), but, in the lower thorax, Ppl increased slightly (0.05 cm H2O.G-1).	Water	196-199	periplakin	Canis lupus familiaris	164-167
6497818-6	1984	When active muscular tone was removed, the rate of Ppl change increased in the upper thorax (-2.55 cm H2O.G-1), but not in more dependent regions.	Water	102-105	periplakin	Canis lupus familiaris	51-54
6497818-7	1984	In the pig, Ppl became more negative with +Gz stress (upper = -3.3; middle = -1.99; lower = -2.16 cm H2O.G-1), and without active muscular tone, the rate of Ppl change tended to increase in all regions (upper = -4.3; middle = -3.47; lower = -2.97 cm H2O.G-1).	Water	101-104	periplakin	Sus scrofa	12-15
6497818-7	1984	In the pig, Ppl became more negative with +Gz stress (upper = -3.3; middle = -1.99; lower = -2.16 cm H2O.G-1), and without active muscular tone, the rate of Ppl change tended to increase in all regions (upper = -4.3; middle = -3.47; lower = -2.97 cm H2O.G-1).	Water	250-253	periplakin	Sus scrofa	12-15
6497818-7	1984	In the pig, Ppl became more negative with +Gz stress (upper = -3.3; middle = -1.99; lower = -2.16 cm H2O.G-1), and without active muscular tone, the rate of Ppl change tended to increase in all regions (upper = -4.3; middle = -3.47; lower = -2.97 cm H2O.G-1).	Water	250-253	periplakin	Sus scrofa	157-160
6472364-2	1984	After water deprivation, the older men had greater increases in plasma osmolality, sodium concentration, and vasopressin levels.	Water	6-11	arginine vasopressin	Homo sapiens	109-120
6514994-4	1984	The reabsorption of water was considered in relation to the plasma vasopressin values.	Water	20-25	vasopressin	Sus scrofa	67-78
6472364-5	1984	We conclude that after 24 hours of water deprivation, there is a deficit in thirst and water intake in healthy elderly men, as compared with younger men, although vasopressin osmoreceptor responsiveness is maintained or even increased.	Water	35-40	arginine vasopressin	Homo sapiens	163-174
6380889-4	1984	The findings are best explained by a vasopressin-induced increase in plasma volume, which in the absence of fluid retention is likely to have been due to a redistribution of body water.	Water	179-184	arginine vasopressin	Homo sapiens	37-48
6501166-3	1984	Biotin and B12 are usually present in pharmaceutical products at concentrations 100-1000 times lower than other commonly occurring water-soluble vitamins.	Water	131-136	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	11-14
6432777-2	1984	Modification of the three carboxyl groups on adrenodoxin using a water-soluble carbodiimide (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) caused a weakening of the binding of this iron-sulfur protein to both its electron donor protein, adrenodoxin reductase, and its electron acceptor protein, cytochrome P-450scc.	Water	65-70	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	296-315
6463044-4	1984	on Purina laboratory rat chow and tap water.	Water	38-43	nuclear RNA export factor 1	Rattus norvegicus	34-37
6380316-1	1984	Angiotensin II and aldosterone increase in response to sodium deficiency to promote sodium and water conservation.	Water	95-100	angiotensinogen	Rattus norvegicus	0-14
6329294-1	1984	Antidiuretic hormone (ADH) increases transepithelial flux of water and particular solutes across the amphibian urinary bladder and mammalian collecting duct by increasing the permeability of the apical surface.	Water	61-66	arginine vasopressin	Homo sapiens	0-26
6747992-0	1984	The preferred solution conformation of warfarin at the active site of cytochrome P-450 based on the CD spectra in octanol/water model system.	Water	122-127	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-86
6089944-5	1984	These receptors may be involved in the direct control of Na+ and water transport by AII.	Water	65-70	angiotensinogen	Rattus norvegicus	84-87
6093943-0	1984	Effect of intracerebroventricularly administered octopamines and synephrines on angiotensin II-induced water intake in rats.	Water	103-108	angiotensinogen	Rattus norvegicus	80-94
6086885-4	1984	A renal alpha-2 adrenoceptor response was demonstrated by showing that epinephrine could reverse the effect of vasopressin on water and sodium in the presence of beta blockade and alpha-1 destruction by POB.	Water	126-131	arginine vasopressin	Rattus norvegicus	111-122
6430138-3	1984	Significant histamine release was seen above 360 mOsm/kg H2O, increasing to 11.9 +/- 1.0% at 770 mOsm/kg H2O, and release was synergistically enhanced by anti-IgE.	Water	57-60	immunoglobulin heavy constant epsilon	Homo sapiens	159-162
6741397-8	1984	Mean urinary AVP excretion was 73 +/- 43 ng/day with ad libitum water intake and normal activity.	Water	64-69	arginine vasopressin	Homo sapiens	13-16
6430138-3	1984	Significant histamine release was seen above 360 mOsm/kg H2O, increasing to 11.9 +/- 1.0% at 770 mOsm/kg H2O, and release was synergistically enhanced by anti-IgE.	Water	105-108	immunoglobulin heavy constant epsilon	Homo sapiens	159-162
6377928-2	1984	Dialyzed acid-treated kidney extract (1 g tissue per ml water) produced a prolonged pressor response in unanesthetized turtles, which was eliminated by boiling the extract or by pretreating the turtle with [Sar1, Ile8]angiotensin II.	Water	56-61	angiotensinogen	Rattus norvegicus	218-232
6466259-3	1984	The greater suppression of tap water intake and the stronger conditioned aversion in the mouse as the angle of tilt was increased in this experiment are consistent with predictions from similar experiments with human subjects where motion sickness develops more rapidly as the angle of tilt is increased.	Water	31-36	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	27-30
6742862-3	1984	Oxidation of ribulose bisphosphate (RuBP) by RuBP carboxylase-oxygenase (EC 4.1.1.39) results in the formation of (2R)-[2-3H1, 14C]glycolic acid which, on oxidation by glycolate oxidase (EC 1.1.3.1), releases 3H to water.	Water	215-220	peroxisomal (S)-2-hydroxy-acid oxidase-like	Nicotiana tabacum	168-185
6466259-2	1984	Conditioned taste aversion occurred in all mice that were rotated, but the intake of tap water was suppressed only in mice that were rotated at 15 or 20 degrees of tilt.	Water	89-94	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	85-88
6487699-2	1984	Water was utilized as the optical coupling agent between the sample and the ATR element.	Water	0-5	ATR serine/threonine kinase	Homo sapiens	76-79
6089971-3	1984	Angiotensin II (250 ng or 25 ng) elicited water intakes averaging 9.25 +/- 0.52 ml and 4.35 +/- 0.44 ml respectively in 15 min with latencies of less than 3 min.	Water	42-47	angiotensinogen	Rattus norvegicus	0-14
6469902-4	1984	C16 and C18:1 co-elute in the acetonitrile-water system but are separated using an isocratic methanol-acetonitrile-water system.	Water	43-48	Bardet-Biedl syndrome 9	Homo sapiens	8-11
6375803-3	1984	The design was double-blind with cross-over, the irrigation was one litre of tap water to which was added in randomized sequence placebo, prostaglandin *2 (350, 700 and 1400 micrograms) or bisacodyl (1.25, 2.5 and 5 mg).	Water	81-86	SEC14 like lipid binding 2	Homo sapiens	77-80
6489919-1	1984	The study was undertaken to elucidate the effect of beta 1 adrenoceptor blocking agent, metoprolol, on water drinking activity in Wistar Kyoto rats (WKY).	Water	103-108	adrenoceptor beta 1	Rattus norvegicus	52-71
6469902-4	1984	C16 and C18:1 co-elute in the acetonitrile-water system but are separated using an isocratic methanol-acetonitrile-water system.	Water	115-120	Bardet-Biedl syndrome 9	Homo sapiens	8-11
6086666-11	1984	In addition, a comparison of reported diffusion values of a variety of molecules in water and in cells indicates that cytoplasmic structure plays an important role in the diffusion of proteins such as bovine serum albumin.	Water	84-89	albumin	Homo sapiens	208-221
6329469-5	1984	Angiotensin II treated rats showed a four-fold increase in water intake and urine volume and a moderate increase in blood pressure; these effects were not observed in rats given saline i.c.v.	Water	59-64	angiotensinogen	Rattus norvegicus	0-14
6563062-6	1984	Ventricular perfusion with plasma also led to an increase of cerebral water content which was restricted to the white matter, but involved all brain tissue areas, if bradykinin was used.	Water	70-75	kininogen 1	Canis lupus familiaris	166-176
6431661-7	1984	Thermal denaturation of adventitious fibrinogen resulted in electrophoretically pure fibronectin which, following lyophilization and reconstitution with pure water, retained biological properties in an in vitro assay designed to reflect opsonic activity.	Water	158-163	fibronectin 1	Homo sapiens	85-96
6235862-1	1984	The distribution of lipophilic anion of phenyldicarbaundecarborane (PCB-) between water phase and fragments of sarcoplasmic reticulum (SR) from skeletal muscle was studied, using a bilayer lipid membrane (BLM) as a selective electrode.	Water	82-87	pyruvate carboxylase	Homo sapiens	68-71
16346563-4	1984	However, samples taken from the sediment-water interface contained as much as 3 muM methane and 50 CFU of methane-oxidizing bacteria per ml and showed significant rates of methane oxidation and incorporation.	Water	41-46	latexin	Homo sapiens	80-83
6733244-2	1984	A variety of transport properties have been measured for solutions of the water soluble polymer poly(ethylene oxide)(PEO) with molecular weights ranging from 200 to 14,000, and volume fractions ranging from 0-80%.	Water	74-79	twinkle mtDNA helicase	Homo sapiens	117-120
6426521-1	1984	Human liver acid alpha-glucosidase (1,4-alpha-D-glucan glucohydrolase, EC 3.2.1.3) was modified with water soluble carbodiimide in the presence of p-aminophenyl-beta-D-galactopyranoside.	Water	101-106	alpha-glucosidase	Ricinus communis	17-34
6093817-2	1984	All these compounds in water have the CD curves characteristic of random coil, CD spectra of analogue ACTH-(1-24)-tetracosapeptide and hexalysine-containing analogue ACTH-(11-24)-tetradecapeptide in trifluoroethanol indicate the presence of alpha-helices.	Water	23-28	proopiomelanocortin	Homo sapiens	102-106
6093817-2	1984	All these compounds in water have the CD curves characteristic of random coil, CD spectra of analogue ACTH-(1-24)-tetracosapeptide and hexalysine-containing analogue ACTH-(11-24)-tetradecapeptide in trifluoroethanol indicate the presence of alpha-helices.	Water	23-28	proopiomelanocortin	Homo sapiens	166-170
6733244-6	1984	A 25% (by volume) solution of PEO exhibits an average dielectric relaxation frequency of the suspending water of one half that of pure water, with clear evidence of a distribution of relaxation times present.	Water	104-109	twinkle mtDNA helicase	Homo sapiens	30-33
6733244-6	1984	A 25% (by volume) solution of PEO exhibits an average dielectric relaxation frequency of the suspending water of one half that of pure water, with clear evidence of a distribution of relaxation times present.	Water	135-140	twinkle mtDNA helicase	Homo sapiens	30-33
6329898-5	1984	The reduction of antidiuretic hormone (ADH) secretion in jerboas fed a water-enriched diet compared to those on a dry diet (75 +/- 25 pM versus 372 +/- 86 pM) was accompanied by an increase in the number of liver vasopressin receptors (2.79 +/- 0.53 versus 1.25 +/- 0.14 pmol [3H]vasopressin bound/mg protein).	Water	71-76	arginine vasopressin	Rattus norvegicus	213-224
6398235-0	1984	[Reactions of the renin-aldosterone system to water load tests].	Water	46-51	renin	Homo sapiens	18-23
6329898-5	1984	The reduction of antidiuretic hormone (ADH) secretion in jerboas fed a water-enriched diet compared to those on a dry diet (75 +/- 25 pM versus 372 +/- 86 pM) was accompanied by an increase in the number of liver vasopressin receptors (2.79 +/- 0.53 versus 1.25 +/- 0.14 pmol [3H]vasopressin bound/mg protein).	Water	71-76	arginine vasopressin	Rattus norvegicus	280-291
6426310-1	1984	To test the hypothesis that antidiuretic hormone- (ADH) dependent water permeability is associated with changes in apical membrane area, hormone-dependent water flow and capacitance changes were measured in the toad urinary bladder under a number of different conditions.	Water	66-71	arginine vasopressin	Homo sapiens	28-48
6400012-0	1984	Reactions of the renin-aldosterone system to water loading tests.	Water	45-50	renin	Homo sapiens	17-22
6747845-1	1984	Water intake induced by injection of 0.2 M-NaCl into the lateral preoptic area was increased by the injection of angiotensin II into the subfornical organ of rats.	Water	0-5	angiotensinogen	Rattus norvegicus	113-127
6747845-7	1984	Dehydration of the lateral preoptic area by means of 0.2 M-NaCl in combination with intravenous infusion of angiotensin II caused a summation of effects in terms of the water intake, without changing cardiovascular alterations induced by the infusion of angiotensin II.	Water	169-174	angiotensinogen	Rattus norvegicus	108-122
6747845-8	1984	A summation of effects in the water intake, but not in blood pressure, was also observed when 0.5 M-NaCl was infused intravenously in combination with the injection of angiotensin II into subfornical organ and into the lateral preoptic area.	Water	30-35	angiotensinogen	Rattus norvegicus	168-182
6426310-1	1984	To test the hypothesis that antidiuretic hormone- (ADH) dependent water permeability is associated with changes in apical membrane area, hormone-dependent water flow and capacitance changes were measured in the toad urinary bladder under a number of different conditions.	Water	66-71	arginine vasopressin	Homo sapiens	51-54
6426310-1	1984	To test the hypothesis that antidiuretic hormone- (ADH) dependent water permeability is associated with changes in apical membrane area, hormone-dependent water flow and capacitance changes were measured in the toad urinary bladder under a number of different conditions.	Water	155-160	arginine vasopressin	Homo sapiens	28-48
6426310-1	1984	To test the hypothesis that antidiuretic hormone- (ADH) dependent water permeability is associated with changes in apical membrane area, hormone-dependent water flow and capacitance changes were measured in the toad urinary bladder under a number of different conditions.	Water	155-160	arginine vasopressin	Homo sapiens	51-54
6426310-10	1984	Removal of serosal Na diminished cAMP-dependent Jv and delta C. The results confirmed the close relationship between ADH-dependent water permeability and membrane capacitance.	Water	131-136	arginine vasopressin	Homo sapiens	117-120
6325596-1	1984	The interaction between human angiotensin-II and Mn(II) ions in water solution has been delineated by nmr and esr experiments.	Water	64-69	angiotensinogen	Homo sapiens	30-44
6329483-6	1984	Yohimbine (300 micrograms/kg, SC) reversed the antidipsogenic effect of centrally administered clonidine (32 micrograms/kg, IVT) on angiotensin II-induced (200 micrograms/kg, SC) water intake.	Water	179-184	angiotensinogen	Rattus norvegicus	132-146
6365943-4	1984	In response to the water load, plasma osmolality and plasma ADH levels decreased in the 3 groups.	Water	19-24	arginine vasopressin	Homo sapiens	60-63
6365943-5	1984	ADH levels remained significantly greater in group 1 than in groups 2 and 3 from 2-4 h after the water load despite more marked hypoosmolality in group 1 compared with that in either of the 2 control groups.	Water	97-102	arginine vasopressin	Homo sapiens	0-3
6365943-11	1984	Two patients with CHF, who excreted more than 75% of the water load, also had low plasma basal ADH levels.	Water	57-62	arginine vasopressin	Homo sapiens	95-98
6365943-14	1984	The reasons for this inappropriate response of plasma ADH during a water load in patients with CHF are probably multifactorial.	Water	67-72	arginine vasopressin	Homo sapiens	54-57
6371049-5	1984	ST-II ETEC was detected in water collected from 3 of 57 clay jars containing water used to bathe at three pig farms, in 1 jar used to bathe immediately after working in the barn, and from one farmer who did not have a recent history of diarrhea.	Water	27-32	ETEC	Sus scrofa	6-10
6716102-3	1984	This study has also shown that the incorporation of VO43 - ions in the Ca10 (PO4)6(OH)2 matrix at low temperatures is only possible if the hydroxyapatite is in the amorphous state.	Water	83-87	carbonic anhydrase 10	Homo sapiens	71-75
6371049-5	1984	ST-II ETEC was detected in water collected from 3 of 57 clay jars containing water used to bathe at three pig farms, in 1 jar used to bathe immediately after working in the barn, and from one farmer who did not have a recent history of diarrhea.	Water	77-82	ETEC	Sus scrofa	6-10
6726173-2	1984	Antidiuretic hormone (ADH) induces a large increase in the water permeability of the luminal membrane of toad urinary bladder.	Water	59-64	arginine vasopressin	Homo sapiens	0-20
6726173-2	1984	Antidiuretic hormone (ADH) induces a large increase in the water permeability of the luminal membrane of toad urinary bladder.	Water	59-64	arginine vasopressin	Homo sapiens	22-25
6377337-4	1984	This indicates that insulin possesses a markedly lower quantity of water of hydration than has been observed for globular proteins containing a higher proportion of hydrophilic groups on the surface of the molecule.	Water	67-72	insulin	Homo sapiens	20-27
6702400-0	1984	The response of plasma arginine vasopressin to 14 h water deprivation in the elderly.	Water	52-57	arginine vasopressin	Homo sapiens	32-43
6716133-3	1984	Drinking of both milk and water by 2-day-olds injected with angiotensin II (Ang II) was confirmed.	Water	26-31	angiotensinogen	Rattus norvegicus	60-74
6716133-3	1984	Drinking of both milk and water by 2-day-olds injected with angiotensin II (Ang II) was confirmed.	Water	26-31	angiotensinogen	Rattus norvegicus	76-82
6728146-7	1984	It is hypothesized that vasopressin, by regulating the water permeability of the brain capillaries, the choroid plexus, and the cerebrospinal fluid absorption structures, plays an important role in controlling the brain fluid and electrolyte balance during the course of SAH.	Water	55-60	arginine vasopressin	Rattus norvegicus	24-35
6726174-2	1984	The value of Pf/Pd(w) for the antidiuretic hormone-induced water permeation pathway.	Water	59-64	arginine vasopressin	Homo sapiens	30-50
6726174-7	1984	Two channel models consistent both with this value and the impermeability of the ADH-induced water permeation pathway to small nonelectrolytes are: (a) a long (approximately equal to 50 A), small-radius (approximately equal to 2 A) pore through which 17 water molecules pass in single-file array, and (b) a shower-head-like structure in which the stem is long and of large radius (approximately equal to 20 A) and the cap has numerous short, small-radius (approximately equal to 2 A) pores.	Water	93-98	arginine vasopressin	Homo sapiens	81-84
6726174-7	1984	Two channel models consistent both with this value and the impermeability of the ADH-induced water permeation pathway to small nonelectrolytes are: (a) a long (approximately equal to 50 A), small-radius (approximately equal to 2 A) pore through which 17 water molecules pass in single-file array, and (b) a shower-head-like structure in which the stem is long and of large radius (approximately equal to 20 A) and the cap has numerous short, small-radius (approximately equal to 2 A) pores.	Water	254-259	arginine vasopressin	Homo sapiens	81-84
6422764-4	1984	Insulin (500 ng/ml) further augmented follicle-stimulating hormone (FSH)-induced aromatase activity, as evidenced both by an increase in 17 beta-estradiol production and by the release of tritiated water from [1 beta-3H]testosterone by granulosa cells.	Water	198-203	insulin	Homo sapiens	0-7
6702400-1	1984	The response of plasma arginine vasopressin (AVP) to 14 h water deprivation was investigated in 30 healthy elderly individuals ranging in age from 63 to 87 years, with a mean age of 76.5 years.	Water	58-63	arginine vasopressin	Homo sapiens	32-43
6473156-1	1984	Vasoactive intestinal polypeptide (VIP) induces intestinal secretion of water and electrolytes in experimental animals and man.	Water	72-77	vasoactive intestinal peptide	Rattus norvegicus	35-38
6372781-6	1984	These rises in ADH and aldosterone may act to retain body water, and the latter may exaggerate alkalosis; thus, these hormonal changes may be related to acute mountain sickness.	Water	58-63	arginine vasopressin	Homo sapiens	15-18
6144179-5	1984	Both the gastrointestinal peptides vasoactive intestinal peptide (VIP) and secretin reduce the net water absorption in the gallbladder.	Water	99-104	vasoactive intestinal peptide	Homo sapiens	66-69
6695975-1	1984	As evidence continues to accumulate supporting a specific effect of prolactin on the permeability of reflected fetal membranes to tritiated water, no information on the role of decidual prolactin in this process is available.	Water	140-145	prolactin	Homo sapiens	68-77
6486775-4	1984	The effect of simultaneous administration of naloxone and clonidine at these submaximal doses was an additive attenuation of both angiotensin II- and isoproterenol-induced water intakes.	Water	172-177	angiotensinogen	Rattus norvegicus	130-144
6699913-6	1984	For dried lysozyme (water content less than or equal to 0.5%, w/w) a nearly linear increase with frequency and an exponential increase with temperature of the absorption coefficient is observed between 50 K and 300 K. This frequency and temperature dependence is described by relaxation processes in asymmetric double-well potentials with relaxation times in the picosecond range.	Water	20-25	lysozyme	Homo sapiens	10-18
6695975-7	1984	These in vitro results may suggest that the accumulation of decidual prolactin at the choriodecidual interface in vivo supports bulk water flow across fetal membrane from the amniotic to the maternal compartments.	Water	133-138	prolactin	Homo sapiens	69-78
6693949-8	1984	Four of the animals that had a hyponatremic and natriuretic response following SAH showed a normal regulation of vasopressin in response to both a water challenge and hypertonic saline challenge.	Water	147-152	arginine vasopressin	Homo sapiens	113-124
6319141-4	1984	A drop in the calcium concentration of the water induces an increase in the immunoassayable calmodulin concentration of mucus, which indicates that the function of calmodulin in mucus is related to control of permeability of the skin epithelium to water and ions.	Water	43-48	calmodulin	Bos taurus	92-102
6319141-4	1984	A drop in the calcium concentration of the water induces an increase in the immunoassayable calmodulin concentration of mucus, which indicates that the function of calmodulin in mucus is related to control of permeability of the skin epithelium to water and ions.	Water	43-48	calmodulin	Bos taurus	164-174
6319141-4	1984	A drop in the calcium concentration of the water induces an increase in the immunoassayable calmodulin concentration of mucus, which indicates that the function of calmodulin in mucus is related to control of permeability of the skin epithelium to water and ions.	Water	248-253	calmodulin	Bos taurus	92-102
6319141-4	1984	A drop in the calcium concentration of the water induces an increase in the immunoassayable calmodulin concentration of mucus, which indicates that the function of calmodulin in mucus is related to control of permeability of the skin epithelium to water and ions.	Water	248-253	calmodulin	Bos taurus	164-174
6472554-0	1984	Vasopressin fails to restore postnatally the stunted brain development in the Brattleboro rat, but affects water metabolism permanently.	Water	107-112	arginine vasopressin	Rattus norvegicus	0-11
6546972-9	1984	Water deprivation for 48 h increased plasma vasopressin concentrations from 0.7 +/- 0.1 to 2.8 +/- 0.1 microU/ml and increased blood pressure from 112 +/- 2 to 123 +/- 1 mm Hg.	Water	0-5	arginine vasopressin	Rattus norvegicus	44-55
6546972-0	1984	Cardiovascular response to vasopressin vasopressor antagonist administration during water deprivation in the rat.	Water	84-89	arginine vasopressin	Rattus norvegicus	27-38
6729272-5	1984	Cross-sectional area decreased only at a Ptp of 6 cm H2O.	Water	53-56	protein tyrosine phosphatase non-receptor type 13	Canis lupus familiaris	41-44
6729272-9	1984	At a Ptp of 2 cm H2O, the difference Db1 (d) - Db1 (nd) was positive near the hilus, decreased to zero in the lung periphery, and increased with edema.	Water	17-20	protein tyrosine phosphatase non-receptor type 13	Canis lupus familiaris	5-8
6699118-3	1984	The partition of serum albumin between the two aqueous phases of a polyethylene glycol-dextran-water two-phase system is strongly influenced by replacing a small fraction of the polyethylene glycol by its palmitate ester.	Water	95-100	albumin	Homo sapiens	17-30
6701605-1	1984	Chronic granulomatous disease is characterized by recurrent infections with microorganisms which produce catalase, an enzyme that detoxifies endogenous or exogenous hydrogen peroxide to water and oxygen.	Water	186-191	catalase	Homo sapiens	105-113
6707135-3	1984	A reversed-phase (RP-8) column is used with acetonitrile and water as the mobile phase.	Water	61-66	programmed cell death 2	Homo sapiens	18-22
6739224-1	1984	The effect of [1-(beta-mercapto-beta,beta- cyclopentamethylene -propionic acid)2-0- ethyltyrosine ,4-valine] arginine vasopressin on the water metabolism was studied in rat.	Water	137-142	arginine vasopressin	Rattus norvegicus	118-129
6372762-3	1984	Fibronectin was extracted from pulps after first removing blood by washing with water, confirmed by eventual negative reaction on alpha 2-macroglobulin.	Water	80-85	fibronectin 1	Homo sapiens	0-11
6372762-5	1984	The fibronectin quantified by electro-immunoassay and expressed as percentage of dry weight was 0.030 per cent in the water extract, 0.094 per cent in the collagenase extract and 0.109 per cent in the hyaluronidase extract.	Water	118-123	fibronectin 1	Homo sapiens	4-15
6318856-1	1984	Injection of insulin to the CSF in the presence of spontaneous diuresis and hydration gives rise to the growth of reabsorption of osmotically free water accompanied by high tubular transport, as well as to the development of antinatriuresis and inhibition of diuresis.	Water	147-152	insulin	Homo sapiens	13-20
6318856-3	1984	Secondary activation of vasopressin secretion and release in the blood may be mediated via these structures, as a result of which reabsorption of osmotically free water in renal tubules gets increased.	Water	163-168	arginine vasopressin	Homo sapiens	24-35
6704587-7	1984	Since it is well known that the mechanism of water- or alcohol-induced diuresis is an inhibition of vasopressin release, the present results suggest that naloxone could prevent this inhibition.	Water	45-50	arginine vasopressin	Rattus norvegicus	100-111
6537965-1	1984	Water intake elicited by microinjection of the hormone angiotensin-II into the preoptic region of cyclic female rats was significantly less on days of vaginal oestrus than at dioestrus or metoestrus, whereas the drinking of 2.7% NaCl solution, to which rats also had access, did not vary with the cycle.	Water	0-5	angiotensinogen	Rattus norvegicus	55-69
6320654-1	1984	8-Bromoadenosine 3",5"-cyclic monophosphate [an analogue of adenosine 3",5"-cyclic monophosphate (cAMP), the intracellular mediator for antidiuretic hormone (ADH) action] induces, in frog urinary bladder, an increase in water permeability that is rapidly and reversibly inhibited by cellular acidification.	Water	220-225	arginine vasopressin	Homo sapiens	136-156
6099984-9	1984	It was suggested that the brain shrinkage of epileptics induced by ACTH treatment might be caused by decreased water content and not cellular degradation.	Water	111-116	proopiomelanocortin	Homo sapiens	67-71
6468729-2	1984	Degradation of the soluble DBH and acidic chromogranins by activation of endogenous proteases occurred during lysis in H2O.	Water	119-122	dopamine beta-hydroxylase	Bos taurus	27-30
6142809-1	1984	Water deprivation in gerbils and rats for 5 and 3 days respectively resulted in the same degree of dehydration of the animals and similar depletion of the neurohypophyseal vasopressin stores.	Water	0-5	arginine vasopressin	Rattus norvegicus	172-183
6146444-7	1984	This coupled with a functional renin-angiotensin system regulates water and electrolyte balance.	Water	66-71	renin	Homo sapiens	31-36
6373427-16	1984	The [lipase-colipase] complex, which is also stabilized by the substrate, would be fixed at the triglyceride/water interface, i.e. by passing through the layer of adsorbed amphipathic compounds (bile salts, phospholipids, fatty acids, proteins) owing to their hydrophobic and ionic properties, and by positioning into the interface by ionizable colipase groups.	Water	109-114	colipase	Homo sapiens	12-20
6373427-16	1984	The [lipase-colipase] complex, which is also stabilized by the substrate, would be fixed at the triglyceride/water interface, i.e. by passing through the layer of adsorbed amphipathic compounds (bile salts, phospholipids, fatty acids, proteins) owing to their hydrophobic and ionic properties, and by positioning into the interface by ionizable colipase groups.	Water	109-114	colipase	Homo sapiens	345-353
6700262-2	1984	The cellular water space was measured with 3H2O, and glucocorticoid receptor number was measured in a whole-cell binding assay with [3H]dexamethasone at 30 and 37 degrees C. The intracellular water phase concentration of glucocorticoid receptors (around 40 nmol/l cell water), and the dependence of receptor affinity on temperature were similar in normal and malignant rodent and human cells.	Water	192-197	nuclear receptor subfamily 3 group C member 1	Homo sapiens	43-76
6546308-3	1984	However, binding of phage ap3 occurred at the interfaces of hexadecane-in-water emulsions specifically stabilized by emulsan polymers.	Water	74-79	adaptor-related protein complex 3, beta 1 subunit	Mus musculus	26-29
6699783-0	1984	Central effects of dopamine on vasopressin release in the normally hydrated and water-loaded rat.	Water	80-85	arginine vasopressin	Rattus norvegicus	31-42
6700262-2	1984	The cellular water space was measured with 3H2O, and glucocorticoid receptor number was measured in a whole-cell binding assay with [3H]dexamethasone at 30 and 37 degrees C. The intracellular water phase concentration of glucocorticoid receptors (around 40 nmol/l cell water), and the dependence of receptor affinity on temperature were similar in normal and malignant rodent and human cells.	Water	192-197	nuclear receptor subfamily 3 group C member 1	Homo sapiens	43-76
6143305-2	1984	The addition of naloxone to a meal consisting of 50 g sucrose dissolved in 200 ml water augmented the rise of plasma insulin levels significantly during the first 30 min after its ingestion and reduced the rise in plasma insulin and pancreatic polypeptide and elevated glucagon levels during the last 30 min of the experimental period.	Water	82-87	insulin	Homo sapiens	117-124
6320032-9	1984	Other areas of central regulation where VP may be important include circadian rhythmicity, control of water intake, control of permeability of brain capillaries to water, central regulation of ACTH release and nociception.	Water	102-107	arginine vasopressin	Homo sapiens	40-42
6320032-9	1984	Other areas of central regulation where VP may be important include circadian rhythmicity, control of water intake, control of permeability of brain capillaries to water, central regulation of ACTH release and nociception.	Water	164-169	arginine vasopressin	Homo sapiens	40-42
6324011-1	1984	Water immersion up to the neck (WI) results in a central hypervolemia; the increased atrial pressure, evoked by this maneuver, stimulates low pressure receptors (LPR) which exert tonic inhibition on sympathetic activity and suppresses both the renin (PRA)-aldosterone (PA) system and the ACTH-cortisol axis in normal man.	Water	0-5	renin	Homo sapiens	244-249
6689019-1	1983	Vasopressin and oxytocin are nonapeptide hormones that regulate water metabolism and lactation, respectively.	Water	64-69	arginine vasopressin	Rattus norvegicus	0-11
6424274-2	1984	A mobile phase of methanol:water (35:65) passed through a mu-Bondapak C-18 column at a rate of 1.0 ml/min produced a sharp, symmetrical band for mitomycin C.	Water	27-32	Bardet-Biedl syndrome 9	Homo sapiens	70-74
6355240-1	1983	Arginine vasopressin, a potent vasoconstrictor and regulator of body water, is frequently increased in the plasma of patients with congestive heart failure.	Water	69-74	arginine vasopressin	Homo sapiens	9-20
6365683-6	1983	By comparison, rats given 100 micrograms of Val5-angiotensin II amide ip increased water intake in the first 2 hr after injection compared with saline-injected and noninjected controls.	Water	83-88	angiotensinogen	Rattus norvegicus	49-63
6579420-4	1983	In normal volunteers the range of plasma AVP was 0.8-14.3 pmol/l, and water loading generally lowered AVP levels.	Water	70-75	arginine vasopressin	Homo sapiens	102-105
6139387-5	1983	Continuous somatostatin infusion at high dose (4 micrograms/kg per min subcutaneously) and low dose (0.8 micrograms/kg per min subcutaneously) for 48-72 h significantly increased (P less than 0.001) the mean aorta plasma somatostatin-like immunoreactivity concentration to 786 +/- 65 and 448 +/- 58 pg/ml, respectively compared with the normal mean of 69 +/- 17 pg/ml in the carbohydrate-fed rat (20% glucose in water ad lib.).	Water	412-417	somatostatin	Rattus norvegicus	11-23
16663330-6	1983	Increases in water stress intensity also caused a significant inhibition in nitrite reductase activities of bacteroids and nodule cytosol within soybean nodules.	Water	13-18	nitrate reductase	Glycine max	76-93
6363363-0	1983	Hypervolemia and plasma vasopressin response during water immersion in men.	Water	52-57	arginine vasopressin	Homo sapiens	24-35
6657001-0	1983	Vasopressin release induced by water deprivation: effects of centrally administered saralasin.	Water	31-36	arginine vasopressin	Rattus norvegicus	0-11
6326414-5	1983	The possibility that prolactin, a proven osmoregulatory hormone in submammalian species but not in mammals and primates, may have an important role in this process is suggested by recent evidence that prolactin regulates tissue water in fetal and newborn animals.	Water	228-233	prolactin	Homo sapiens	21-30
6326414-5	1983	The possibility that prolactin, a proven osmoregulatory hormone in submammalian species but not in mammals and primates, may have an important role in this process is suggested by recent evidence that prolactin regulates tissue water in fetal and newborn animals.	Water	228-233	prolactin	Homo sapiens	201-210
6326414-6	1983	If this hormone assists in the regulation of water and electrolyte content of the brain during the perinatal period then prolactin receptors might be expected at blood-brain and blood-CSF barriers.	Water	45-50	prolactin	Homo sapiens	121-130
6685931-2	1983	Average daily intake (kg/cow) of drinking water and dry matter were 75.4 and 16.9 respectively for animals producing 13.7 kg milk/day in an environment with a mean air temperature and a relative humidity of 26.2 degrees C and 75.7% respectively.	Water	42-47	Weaning weight-maternal milk	Bos taurus	125-129
6666181-0	1983	[The effect of vasopressin analogs on water metabolism].	Water	38-43	arginine vasopressin	Homo sapiens	15-26
6314816-1	1983	The final step in the action of antidiuretic hormone (ADH) is the insertion of aggregates of water-conducting particles into the luminal membrane of the receptor cell.	Water	93-98	arginine vasopressin	Homo sapiens	32-52
6314816-1	1983	The final step in the action of antidiuretic hormone (ADH) is the insertion of aggregates of water-conducting particles into the luminal membrane of the receptor cell.	Water	93-98	arginine vasopressin	Homo sapiens	54-57
6635723-4	1983	Abnormal vasopressin secretion was shown by a plasma vasopressin concentration of 0.5 microU/ml with a plasma osmolality of 268 mOsm/kg water after administration of a fluid challenge consisting of 45 ml/kg body weight.	Water	136-141	arginine vasopressin	Homo sapiens	9-20
6688929-5	1983	Intraperitoneal administration of the AVP analogue (30 micrograms/kg body wt) decreased the mean urinary osmolality in rats after 24 h of fluid deprivation from 3,098 +/- 140 to 797 +/- 155 mosmol/kg H2O (P less than 0.001).	Water	200-203	arginine vasopressin	Rattus norvegicus	38-41
6685931-3	1983	Intake of water per kg dry matter consumed after subtracting water in milk was 5.8 kg.	Water	10-15	Weaning weight-maternal milk	Bos taurus	70-74
6685931-4	1983	Milk yield was positively related to measures of water intake.	Water	49-54	Weaning weight-maternal milk	Bos taurus	0-4
6315005-0	1983	Interaction between cytochrome c and ubiquinone-cytochrome c oxidoreductase: a study with water-soluble carbodiimides.	Water	90-95	cytochrome c, somatic	Homo sapiens	20-32
6317014-5	1983	The rate constant for the water reaction was found to be very small, approximately equal to 2.5 X 10(-6) min-1.	Water	26-31	CD59 molecule (CD59 blood group)	Homo sapiens	105-110
6226653-3	1983	The number of water molecules coordinated to the metal in Eu3+-ATP was estimated to be 2.6; when this complex is bound to hexokinase, 1 water molecule is displaced.	Water	14-19	hexokinase 1	Homo sapiens	122-132
6226653-3	1983	The number of water molecules coordinated to the metal in Eu3+-ATP was estimated to be 2.6; when this complex is bound to hexokinase, 1 water molecule is displaced.	Water	136-141	hexokinase 1	Homo sapiens	122-132
6315005-0	1983	Interaction between cytochrome c and ubiquinone-cytochrome c oxidoreductase: a study with water-soluble carbodiimides.	Water	90-95	cytochrome c, somatic	Homo sapiens	48-60
6315005-1	1983	The role of carboxyl groups on the interaction between ubiquinone-cytochrome c oxidoreductase (Complex III) and cytochrome c has been probed using the two water-soluble carbodiimides EDC (1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide) and CMC (1-cyclohexyl-3-(2-morpholinyl-4-ethyl) carbodiimide metho-p-toluensulphonate).	Water	155-160	cytochrome c, somatic	Homo sapiens	66-78
6315005-1	1983	The role of carboxyl groups on the interaction between ubiquinone-cytochrome c oxidoreductase (Complex III) and cytochrome c has been probed using the two water-soluble carbodiimides EDC (1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide) and CMC (1-cyclohexyl-3-(2-morpholinyl-4-ethyl) carbodiimide metho-p-toluensulphonate).	Water	155-160	cytochrome c, somatic	Homo sapiens	112-124
6226056-1	1983	Drinking water made available to mice was changed from ordinary tap water to tap water containing 30 atom% D2O when the animals were 6 to 8 weeks old.	Water	9-14	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	64-67
6689332-4	1983	A direct effect of 1,25 (OH)2-D on PRL secretion may exist.	Water	24-29	prolactin	Homo sapiens	35-38
6885966-8	1983	kg) was infused in into four healthy nonsmoking adults in whom endogenous AVP was suppressed by oral water loading.	Water	101-106	arginine vasopressin	Homo sapiens	74-77
6646503-1	1983	Interaction of cholecystokinin (CCK) with vasoactive intestinal peptide (VIP) in body shaking response to ice-water immersion was observed in pentobarbital-anesthetized rats.	Water	110-115	vasoactive intestinal peptide	Rattus norvegicus	73-76
6413091-6	1983	ApoB was water-soluble after chromatofocusing.	Water	9-14	apolipoprotein B	Homo sapiens	0-4
6313759-22	1983	Therefore, increased antidiuretic response to VP in the kidneys of CPMD-treated DI rats is due to enhanced osmotic driving force for water reabsorption (lumen-to-interstitium osmotic gradient) in collecting tubules, rather than due to increased VP-dependent water permeability of tubular epithelium.	Water	133-138	arginine vasopressin	Rattus norvegicus	46-48
6313759-22	1983	Therefore, increased antidiuretic response to VP in the kidneys of CPMD-treated DI rats is due to enhanced osmotic driving force for water reabsorption (lumen-to-interstitium osmotic gradient) in collecting tubules, rather than due to increased VP-dependent water permeability of tubular epithelium.	Water	258-263	arginine vasopressin	Rattus norvegicus	46-48
6413663-3	1983	A method is described here that uses a liver phantom, containing a dissolved Co-57 B12 capsule, in a water tank.	Water	101-106	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	83-86
6226056-1	1983	Drinking water made available to mice was changed from ordinary tap water to tap water containing 30 atom% D2O when the animals were 6 to 8 weeks old.	Water	9-14	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	77-80
6316861-1	1983	A decrease in extracellular pH is well known to inhibit vasopressin stimulated water flow in the toad bladder.	Water	79-84	arginine vasopressin	Homo sapiens	56-67
6625364-3	1983	Six cases are presented in which drain tract sinograms with water-soluble contrast facilitated the diagnosis of otherwise cryptic intra-abdominal abscesses, retroperitoneal abscesses, or enteric leaks.	Water	60-65	cripto, FRL-1, cryptic family 1	Homo sapiens	122-129
6316861-3	1983	In the present study we evaluated the effect of several maneuvers capable of altering intracellular pH on vasopressin or cyclic AMP stimulated water flow in the toad bladder in the absence of alterations of extracellular pH.	Water	143-148	arginine vasopressin	Homo sapiens	106-117
6316861-4	1983	In the presence of a normal extracellular pH, bladders subjected to a high partial pressure of CO2 or bladders from acidotic toads had a significant decrease in vasopressin or cyclic AMP stimulated water flow as compared to controls.	Water	198-203	arginine vasopressin	Homo sapiens	161-172
6316861-10	1983	It is concluded that alterations of intracellular pH, in the absence of alterations of extracellular pH, are important in regulation of water transport in the toad bladder in response to vasopressin or cyclic AMP.	Water	136-141	arginine vasopressin	Homo sapiens	187-198
18200073-0	1983	Extinction and liquid water content of fog at visible wavelengths.	Water	22-27	zinc finger protein, FOG family member 1	Homo sapiens	39-42
6604062-7	1983	In contrast, the Michaelis constant for BCH uptake was 63 microM; the maximal velocity was 969 mumol/L cell water/min, and the diffusion coefficient was .141 min-1.	Water	108-113	chimerin 2	Homo sapiens	40-43
6888193-7	1983	Spontaneous locomotor of the chronic caffeine group was reduced significantly for 4 days after drug-free tap water was substituted for the caffeine solution.	Water	109-114	nuclear RNA export factor 1	Rattus norvegicus	105-108
6411896-0	1983	Verapamil inhibition of vasopressin-stimulated water flow: possible role of intracellular calcium.	Water	47-52	arginine vasopressin	Homo sapiens	24-35
6411896-1	1983	The effects of the organic calcium antagonists verapamil and methoxyverapamil (D-600) on vasopressin-stimulated water flow in response to an osmotic gradient were investigated.	Water	112-117	arginine vasopressin	Homo sapiens	89-100
6411896-2	1983	When toad bladders were exposed to either verapamil or D-600 for 60 min, vasopressin-stimulated water flow was inhibited.	Water	96-101	arginine vasopressin	Homo sapiens	73-84
6411896-5	1983	Addition of verapamil to the bathing media during recovery from a vasopressin stimulus to block reuptake of calcium into the epithelial cells inhibited water flow in response to a subsequent incubation with vasopressin to a greater extent than the inhibition of water flow when verapamil was present only before exposure to vasopressin.	Water	152-157	arginine vasopressin	Homo sapiens	66-77
6411896-5	1983	Addition of verapamil to the bathing media during recovery from a vasopressin stimulus to block reuptake of calcium into the epithelial cells inhibited water flow in response to a subsequent incubation with vasopressin to a greater extent than the inhibition of water flow when verapamil was present only before exposure to vasopressin.	Water	152-157	arginine vasopressin	Homo sapiens	207-218
6411896-5	1983	Addition of verapamil to the bathing media during recovery from a vasopressin stimulus to block reuptake of calcium into the epithelial cells inhibited water flow in response to a subsequent incubation with vasopressin to a greater extent than the inhibition of water flow when verapamil was present only before exposure to vasopressin.	Water	152-157	arginine vasopressin	Homo sapiens	207-218
6411896-5	1983	Addition of verapamil to the bathing media during recovery from a vasopressin stimulus to block reuptake of calcium into the epithelial cells inhibited water flow in response to a subsequent incubation with vasopressin to a greater extent than the inhibition of water flow when verapamil was present only before exposure to vasopressin.	Water	262-267	arginine vasopressin	Homo sapiens	207-218
6411896-5	1983	Addition of verapamil to the bathing media during recovery from a vasopressin stimulus to block reuptake of calcium into the epithelial cells inhibited water flow in response to a subsequent incubation with vasopressin to a greater extent than the inhibition of water flow when verapamil was present only before exposure to vasopressin.	Water	262-267	arginine vasopressin	Homo sapiens	207-218
6411896-7	1983	The results are consistent with the notion that the calcium antagonists inhibit vasopressin-stimulated water flow by virtue of depleting a critical pool of intracellular calcium rather than preventing the simultaneous entry of calcium from extracellular sites during the exposure to vasopressin.	Water	103-108	arginine vasopressin	Homo sapiens	80-91
6411896-7	1983	The results are consistent with the notion that the calcium antagonists inhibit vasopressin-stimulated water flow by virtue of depleting a critical pool of intracellular calcium rather than preventing the simultaneous entry of calcium from extracellular sites during the exposure to vasopressin.	Water	103-108	arginine vasopressin	Homo sapiens	283-294
6193486-2	1983	Proton NMR spectra of a covalently linked self-complementary RNA X DNA hybrid, r(GCG)-d(TATACGC), are recorded in H2O and D2O.	Water	114-117	glucagon	Homo sapiens	81-84
6310125-3	1983	It is shown that the reorganization energy of cytochrome c is much smaller than the corresponding energy for electron transfer in water and that this is consistent with the role for cytochromes as electron transfer catalysts.	Water	130-135	cytochrome c, somatic	Homo sapiens	46-58
6415266-13	1983	The hyperpolarization-activated current is abolished after prolonged exposure of the cell to an artificial sea water where NO3- ions replace Cl- ions, as well as after intracellular injections of NO3- ions.	Water	111-116	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
6415266-13	1983	The hyperpolarization-activated current is abolished after prolonged exposure of the cell to an artificial sea water where NO3- ions replace Cl- ions, as well as after intracellular injections of NO3- ions.	Water	111-116	NBL1, DAN family BMP antagonist	Homo sapiens	196-199
6889009-0	1983	Prolactin: a hormonal regulator of the neonatal tissue water reservoir.	Water	55-60	prolactin	Oryctolagus cuniculus	0-9
6571696-1	1983	Vasoactive intestinal polypeptide (VIP), a 28-amino acid peptide originally isolated from porcine duodenum, is present not only in gastrointestinal tissues but also in neural tissues, possibly as a neurotransmitter, and exhibits a wide range of biological actions (for example, relaxation of smooth muscle, stimulation of intestinal water and electrolyte secretion and release of insulin, glucagon and several anterior pituitary hormones).	Water	333-338	vasoactive intestinal peptide	Homo sapiens	35-38
6311560-4	1983	The [3H]-water and the ring-substituted radiolabeled products possessed several characteristics of a genuine estrogen receptor protein in that they were resistant to dextran-coated charcoal (DCC) adsorption and their enzymatic formation was inhibited with non-steroidal estrogens like diethylstilbestrol.	Water	9-14	estrogen receptor 1	Homo sapiens	109-126
6408094-6	1983	The rate of interconversion of CO2 and HCO-3 at equilibrium catalyzed by carbonic anhydrase III is not altered when the solvent is changed from H2O to 98% D2O and 2% H2O.	Water	144-147	carbonic anhydrase 3	Homo sapiens	73-95
6889009-2	1983	Animals treated with prolactin or fluphenazine retained more water than did the controls.	Water	61-66	prolactin	Oryctolagus cuniculus	21-30
6635259-0	1983	Vasopressin-like peptides in the rat brain: immunologic and chromatographic behavior and their response to water deprivation.	Water	107-112	arginine vasopressin	Rattus norvegicus	0-11
6408094-6	1983	The rate of interconversion of CO2 and HCO-3 at equilibrium catalyzed by carbonic anhydrase III is not altered when the solvent is changed from H2O to 98% D2O and 2% H2O.	Water	166-169	carbonic anhydrase 3	Homo sapiens	73-95
6869538-4	1983	Vasopressin (Pitressin tannate in oil, 5 U/kg subcutaneously) increased UPGEV and decreased urine volume (V) in rats on ad libitum water intake but did not alter UPGEV during water deprivation.	Water	131-136	arginine vasopressin	Rattus norvegicus	0-11
6307056-0	1983	Actin filaments and vasopressin-stimulated water flow in toad urinary bladder.	Water	43-48	arginine vasopressin	Homo sapiens	20-31
6307056-1	1983	Vasopressin increases the water permeability of the apical membrane of the granular epithelial cells of the toad urinary bladder.	Water	26-31	arginine vasopressin	Homo sapiens	0-11
6877323-3	1983	Infection was associated with eating rice on the oil rig on a particular day (P = 0.03) when an open valve permitted the rig"s drinking-water system to be contaminated by canal water containing sewage (including that from the index patient) discharged from the rig.	Water	136-141	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	121-124
6877323-3	1983	Infection was associated with eating rice on the oil rig on a particular day (P = 0.03) when an open valve permitted the rig"s drinking-water system to be contaminated by canal water containing sewage (including that from the index patient) discharged from the rig.	Water	136-141	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	121-124
6869538-12	1983	Conversely, the marked increase in UPGEV induced by administration of vasopressin during water diuresis may serve to suppress the antidiuretic response and thus play a role in the mediation of escape from physiologically inappropriate antidiuresis.	Water	89-94	arginine vasopressin	Rattus norvegicus	70-81
6357879-3	1983	After reextraction of these LPS preparations with phenol-water, the remaining LPS was either considerably less mitogenic or not mitogenic.	Water	57-62	toll-like receptor 4	Mus musculus	28-31
6357879-3	1983	After reextraction of these LPS preparations with phenol-water, the remaining LPS was either considerably less mitogenic or not mitogenic.	Water	57-62	toll-like receptor 4	Mus musculus	78-81
6357879-4	1983	Purified E. coli 055:B5 LPS, prepared by phenol water extraction, enzyme treatment and column chromatography, was not mitogenic.	Water	48-53	toll-like receptor 4	Mus musculus	24-27
6887859-3	1983	The oxidative transformation of estradiol at the C-2 and C-4 positions in the male rat brain was studied by the transfer of 3H into water from [2-3H]- and [4-3H]-estradiol.	Water	132-137	complement C4A	Rattus norvegicus	57-60
6873379-1	1983	Injections of 0.2 M LiCl i. p. (1 ml/100 g/day) induced polydipsia in rats drinking tap water.	Water	88-93	nuclear RNA export factor 1	Rattus norvegicus	84-87
6888660-2	1983	The amount of water drunk in 1 h was assessed after subcutaneous injection of 5.8% NaCl (13.34 mosm/kg) or of angiotensin II (1.5 mg/kg).	Water	14-19	angiotensinogen	Rattus norvegicus	110-124
6888661-8	1983	On the third day in culture, increasing the osmolality of the culture medium from 295 to 315 mosm/kg H2O by the addition of NaCl resulted in a 2.5-fold increase in VP release from the explants with sham lesions, but did not significantly alter VP release from the explants with AV3V lesions.	Water	101-104	arginine vasopressin	Rattus norvegicus	164-166
6420591-0	1983	[Effects of endogenous prostaglandins and vasopressin on osmotic water flow and activation of adenylate cyclase].	Water	65-70	arginine vasopressin	Homo sapiens	42-53
6308024-5	1983	LiChrosorb RP-18, Nucleosil C18 and muBondapak C18 gave rise to different selectivities when an acidic eluent, methanol-water (25:75) containing 0.2% of 1.8 M H2SO4 was used.	Water	120-125	Bardet-Biedl syndrome 9	Homo sapiens	28-31
6308024-5	1983	LiChrosorb RP-18, Nucleosil C18 and muBondapak C18 gave rise to different selectivities when an acidic eluent, methanol-water (25:75) containing 0.2% of 1.8 M H2SO4 was used.	Water	120-125	Bardet-Biedl syndrome 9	Homo sapiens	47-50
6407335-4	1983	Both groups of rats suppressed AVP secretion appropriately when water loaded.	Water	64-69	arginine vasopressin	Rattus norvegicus	31-34
6874113-1	1983	Desferrioxamine-human serum albumin conjugate was prepared at pH 4.7 using a water-soluble carbodiimide and at pH 7.8 using glutaraldehyde.	Water	77-82	albumin	Homo sapiens	22-35
6408646-1	1983	Toad bladders exposed to vasopressin (ADH) and then fixed on the mucosal surface with 1% glutaraldehyde were highly permeable to water and to urea compared to control bladders fixed in the absence of hormone.	Water	129-134	arginine vasopressin	Homo sapiens	25-36
6865335-3	1983	After uninephrectomy of rats on a normal diet with tap water, the maximal increase in relative weight of the remaining kidney occurred within 2 weeks, and the degree of hypertrophy was estimated as 64%.	Water	55-60	nuclear RNA export factor 1	Rattus norvegicus	51-54
6344330-6	1983	Chronically Pb-exposed rabbits (500 or 1000 ppm in drinking water) had renin half-lives that were not different from controls (6 to 8 min).	Water	60-65	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	71-76
6873379-2	1983	The plasma lithium concentration and its content in the erythrocytes, skeletal muscles, renal tissue were significantly higher in the rats drinking tap water as compared with rats drinking saline.	Water	152-157	nuclear RNA export factor 1	Rattus norvegicus	148-151
6873379-4	1983	Na content in the plasma and the renal cortex--medullar Na gradient were decreased in the "lithium" rats drinking tap water.	Water	118-123	nuclear RNA export factor 1	Rattus norvegicus	114-117
6875967-1	1983	Vasopressin enhanced the absorption of water and Na+ across everted sacs of rat colon descendens but had no effect on absorption across the colon ascendens.	Water	39-44	arginine vasopressin	Rattus norvegicus	0-11
6603607-0	1983	Effects of guanine nucleotides on vasopressin-induced water flow and sodium transport of the frog bladder.	Water	54-59	arginine vasopressin	Homo sapiens	34-45
6877229-3	1983	In the presence of water the oscillation motions of the molecular groups within the macromolecule are observed with frequencies lower 10(8) s-1 at negative temperatures and in the nanosecond range at room temperature.	Water	19-24	proteasome 26S subunit, non-ATPase 1	Homo sapiens	140-143
6855633-6	1983	At Ptp = 25 cm H2O, increases in vascular pressure were associated with significant decreases in the percent cytoplasm occupied by vesicles for both series of experiments.	Water	15-18	protein tyrosine phosphatase non-receptor type 13	Canis lupus familiaris	3-6
6856043-5	1983	Animals with knife cuts and ad libitum access to food and water had significantly higher plasma osmolality (310 +/- 2 mosm/kg), and plasma vasopressin concentration (2.02 +/- 0.5 microunits/ml) than controls (306 +/- 1 mosm/kg and 0.60 +/- 0.04 microunits/ml, respectively).	Water	58-63	arginine vasopressin	Rattus norvegicus	139-150
6856043-7	1983	However, rats with knife cuts deprived of water only had significantly higher plasma osmolality (358 +/- 8 mosm/kg), sodium (164 +/- 19 mEq/l) and vasopressin (17.7 +/- 4 microunits/ml), than similarly treated control animals (317 +/- 1 mosm/kg, 145.5 +/- 1.0 mEq/1, 5.5 +/- 3 microunits/ml, respectively).	Water	42-47	arginine vasopressin	Rattus norvegicus	147-158
6850344-2	1983	The enhancement of feeding by CaM seems to be functionally specific since the response was: (1) abolished by the simultaneous intraventricular infusion of calcineurin, a specific CaM antagonist; (2) not mimicked by another calcium binding protein, troponin C; and (3) independent of the CaM"s lack of effect on body temperature and water intake.	Water	332-337	calmodulin 1	Homo sapiens	30-33
6840081-2	1983	The binding of 64Cu to the water-soluble form of dopamine beta-monooxygenase from bovine adrenal medulla was studied in reconstitution and exchange experiments using high-performance size-exclusion gel chromatography.	Water	27-32	dopamine beta-hydroxylase	Bos taurus	49-76
6603607-1	1983	In the present study, we examined the effects of guanine nucleotides on vasopressin-induced osmotic water flow and sodium transport in the 14-h preincubated frog bladder.	Water	100-105	arginine vasopressin	Homo sapiens	72-83
6603607-3	1983	Gpp(NH)p significantly enhanced vasopressin-induced water flow while it did not affect cyclic AMP-induced water flow.	Water	52-57	arginine vasopressin	Homo sapiens	32-43
6603607-10	1983	These results suggest the guanine nucleotides stimulate the vasopressin-induced osmotic water flow in frog bladder by enhancing the vasopressin-mediated adenylate cyclase activity, so that accumulated cyclic AMP might activate cyclic AMP-dependent protein kinase.	Water	88-93	arginine vasopressin	Homo sapiens	60-71
6603607-10	1983	These results suggest the guanine nucleotides stimulate the vasopressin-induced osmotic water flow in frog bladder by enhancing the vasopressin-mediated adenylate cyclase activity, so that accumulated cyclic AMP might activate cyclic AMP-dependent protein kinase.	Water	88-93	arginine vasopressin	Homo sapiens	132-143
6867069-4	1983	When water-deprived and tested 48 hr later, vasopressin-treated rats found the water tube reliably faster than controls.	Water	5-10	arginine vasopressin	Rattus norvegicus	44-55
6403535-9	1983	Highly flexible proteins, such as apolipoproteins A-I, A-II, and C-I, absorb rapidly and reversibly to air-water interfaces, whereas more rigid proteins, such as the classical globular proteins, interact with the interface more slowly and irreversibly.	Water	107-112	NLR family pyrin domain containing 3	Homo sapiens	34-59
6403535-12	1983	Treatment with acid or base, although causing only minor changes in the circular dichroic spectra, resulted in major increases in the rate of absorption to an air-water interface; under these conditions the rates of absorption were similar to that found for apolipoprotein A-I.	Water	163-168	apolipoprotein A1	Homo sapiens	258-276
6867069-4	1983	When water-deprived and tested 48 hr later, vasopressin-treated rats found the water tube reliably faster than controls.	Water	79-84	arginine vasopressin	Rattus norvegicus	44-55
6682101-2	1983	Intrinsic spin lattice relaxation times for the hyperfine-shifted exchangeable resonances and the downfield heme methyls for the low spin met-cyano-, met-nicotinate-, and deoxy- complexes of soybean leghemoglobin a were determined in H2O.	Water	234-237	leghemoglobin A	Glycine max	199-212
6879144-3	1983	In spite of the limited use until now, PCT has been detected in a great variety of environmental samples such as soil, water, shellfish, fish, seals, birds and terrestrial animals.	Water	119-124	calcitonin related polypeptide alpha	Homo sapiens	39-42
6342378-7	1983	The bound insulin could be removed by washing with water and detergent, but soaking in detergent did not remove a small residual quantity of the bound insulin, suggesting that minimal chemical binding or diffusion of the insulin into the plastic may occur.	Water	51-56	insulin	Homo sapiens	10-17
6132339-1	1983	The water permeability of collecting ducts is greatly increased by the antidiuretic hormone, vasopressin.	Water	4-9	arginine vasopressin	Rattus norvegicus	93-104
6132339-3	1983	IMP aggregates have also been related to an increase in water permeability of two other vasopressin-sensitive epithelia, the amphibian urinary bladder and the amphibian epidermis, and it has been proposed that these specialized membrane domains might represent specific water-permeable membrane patches, induced by the hormone in their respective epithelia.	Water	56-61	arginine vasopressin	Rattus norvegicus	88-99
6299112-3	1983	D600 (200 microM), diltiazem (200 microM), and nifedipine (60 microM) inhibited vasopressin-induced water flow but enhanced adenosine 3",5"-cyclic monophosphate (cAMP)-induced water flow, suggesting that the drugs inhibit cAMP generation in response to vasopressin but enhance the response to exogenous cAMP by inhibiting phosphodiesterase activity.	Water	100-105	arginine vasopressin	Homo sapiens	80-91
6830831-11	1983	Regulation of activities of several membrane-bound enzymes of cholesterol metabolism in which the lipid-transfer protein and cytosolic Z-protein modulate uptake of lower-molecular-weight water-insoluble and water-soluble effectors, respectively, is discussed.	Water	187-192	fatty acid binding protein 1	Rattus norvegicus	135-144
6830831-11	1983	Regulation of activities of several membrane-bound enzymes of cholesterol metabolism in which the lipid-transfer protein and cytosolic Z-protein modulate uptake of lower-molecular-weight water-insoluble and water-soluble effectors, respectively, is discussed.	Water	207-212	fatty acid binding protein 1	Rattus norvegicus	135-144
6829795-4	1983	Slowly most of the KAL rats began to eat chow and drink tap water but remained hypophagic and hypodipsic.	Water	60-65	nuclear RNA export factor 1	Rattus norvegicus	56-59
6829795-6	1983	During water deprivation the recovered KAL rats that would drink tap water ate, and following it they responded with an adequate increase in water consumption.	Water	7-12	nuclear RNA export factor 1	Rattus norvegicus	65-68
6850360-0	1983	Effect of acute administration of isoproterenol and angiotensin II, separately and in combination, on water intake and blood pressure of rats.	Water	102-107	angiotensinogen	Rattus norvegicus	52-66
6829795-6	1983	During water deprivation the recovered KAL rats that would drink tap water ate, and following it they responded with an adequate increase in water consumption.	Water	69-74	nuclear RNA export factor 1	Rattus norvegicus	65-68
6829795-6	1983	During water deprivation the recovered KAL rats that would drink tap water ate, and following it they responded with an adequate increase in water consumption.	Water	69-74	nuclear RNA export factor 1	Rattus norvegicus	65-68
6838716-1	1983	Rats injected with arginine vasopressin (AVP) immediately after exposure to a novel open-field environment found a water tube faster than saline injected rats, when water-deprived 48 h later.	Water	115-120	arginine vasopressin	Rattus norvegicus	28-39
6838716-1	1983	Rats injected with arginine vasopressin (AVP) immediately after exposure to a novel open-field environment found a water tube faster than saline injected rats, when water-deprived 48 h later.	Water	115-120	arginine vasopressin	Rattus norvegicus	41-44
6838716-1	1983	Rats injected with arginine vasopressin (AVP) immediately after exposure to a novel open-field environment found a water tube faster than saline injected rats, when water-deprived 48 h later.	Water	165-170	arginine vasopressin	Rattus norvegicus	28-39
6838716-1	1983	Rats injected with arginine vasopressin (AVP) immediately after exposure to a novel open-field environment found a water tube faster than saline injected rats, when water-deprived 48 h later.	Water	165-170	arginine vasopressin	Rattus norvegicus	41-44
6600981-6	1983	We have shown that, in addition to the influences of H-2 genes, non-H-2 genes can also influence the in vitro hapten-specific CTL response following intravenous pretreatment with water-soluble hapten.	Water	179-184	histocompatibility-2, MHC	Mus musculus	53-56
6875922-0	1983	Plasma prolactin levels and body fluid deficits in the rat: causal interactions and control of water intake.	Water	95-100	prolactin	Rattus norvegicus	7-16
6875922-15	1983	After 24 h water deprivation, plasma prolactin levels rose significantly in both the control and hyperprolactinaemic rats.	Water	11-16	prolactin	Rattus norvegicus	37-46
6875922-20	1983	However, prolactin secretion is stimulated by the combined intra- and extracellular deficits resulting from water deprivation and there is a clearly demonstrated interaction between prolactin and the extracellularly mediated stimulus of angiotensin II.	Water	108-113	prolactin	Rattus norvegicus	9-18
6297593-1	1983	Deuterium exchangeable hyperfine proton NMR resonances of cytochrome c peroxidase (EC 1.11.1.5) are identified in H2O solutions of the enzyme.	Water	114-117	cytochrome c, somatic	Homo sapiens	58-70
6401725-0	1983	The pH dependency of bovine spleen cathepsin B-catalyzed transfer of N alpha-benzyloxycarbonyl-L-lysine from p-nitrophenol to water and dipeptide nucleophiles.	Water	126-131	cathepsin B	Bos taurus	35-46
6401725-2	1983	Cathepsin B has been shown to catalyze the transfer of the N alpha-benzyloxycarbonyl-L-lysyl residue from the corresponding p-nitrophenyl ester substrate to water and dipeptide nucleophiles.	Water	157-162	cathepsin B	Bos taurus	0-11
6304682-1	1983	The water flow according to the osmotic gradient increased under the action of 1 mU/ml of antidiuretic hormone (ADH) from 0,049 +/- 0.017 to 1.31 +/- 0.29 mcl/cm2 min in the presence of hemosorbent SKN in the solution of the frog bladder serous membrane and from 0.054 +/- 0.015 to 0.67 +/- 0.15 mcl/cm2 min without a sorbent.	Water	4-9	arginine vasopressin	Homo sapiens	90-110
6304682-1	1983	The water flow according to the osmotic gradient increased under the action of 1 mU/ml of antidiuretic hormone (ADH) from 0,049 +/- 0.017 to 1.31 +/- 0.29 mcl/cm2 min in the presence of hemosorbent SKN in the solution of the frog bladder serous membrane and from 0.054 +/- 0.015 to 0.67 +/- 0.15 mcl/cm2 min without a sorbent.	Water	4-9	arginine vasopressin	Homo sapiens	112-115
6304682-4	1983	The data obtained allow one to conclude that ADH enhances the water penetration, stimulating at the same time the release of the inhibitor, lowering its interaction with the receptor.	Water	62-67	arginine vasopressin	Homo sapiens	45-48
6306701-2	1983	In hungry pigs working for food, thirsty pigs responding for water, and non-deprived pigs working for sucrose, 20 and 40 units CCK produced significant dose-related decreases in response rates lasting for about 5 min.	Water	61-66	cholecystokinin	Sus scrofa	127-130
6843047-11	1983	In patients with SIADH (Schwartz-Bartter-syndrome) AVP-values were greatly enhanced (greater than 10 pg/ml) when correlated to plasma osmolality (less than 170 mosmol/kg H2O).	Water	170-173	arginine vasopressin	Homo sapiens	51-54
6600981-6	1983	We have shown that, in addition to the influences of H-2 genes, non-H-2 genes can also influence the in vitro hapten-specific CTL response following intravenous pretreatment with water-soluble hapten.	Water	179-184	histocompatibility-2, MHC	Mus musculus	68-71
6402006-7	1983	The strength of transferrin complexation is also compared to that of a series of low molecular weight ligands by using calculated pM values (pM = -log [Ga-(H2O)6]) to express the effective binding strength at pH 7.4.	Water	156-159	transferrin	Homo sapiens	16-27
6401935-9	1983	The results are interpreted within the framework of a previously proposed model of ADH-stimulated water transport in which cytoplasmic vesicular structures fuse with the apical plasma membrane.	Water	98-103	arginine vasopressin	Homo sapiens	83-86
6824944-0	1983	Chronic infusion of angiotensin II into the olfactory bulb elicits an increase in water intake.	Water	82-87	angiotensinogen	Homo sapiens	20-34
6824944-1	1983	Chronic infusion of angiotensin II (ANG II) into the olfactory bulb (OB) elicited a moderate dipsogenesis which occurred only during the dark phase, essentially doubling the water-to-food intake ratio.	Water	174-179	angiotensinogen	Homo sapiens	20-34
6337511-1	1983	The role of angiotensin II in the control of water intake following deprivation of water for varying lengths of time was studied.	Water	45-50	angiotensinogen	Rattus norvegicus	12-26
6337511-9	1983	The data indicate that the water intake of water-deprived rats can be divided into an angiotensin II-dependent component and angiotensin II-independent component.	Water	27-32	angiotensinogen	Rattus norvegicus	86-100
6337511-9	1983	The data indicate that the water intake of water-deprived rats can be divided into an angiotensin II-dependent component and angiotensin II-independent component.	Water	27-32	angiotensinogen	Rattus norvegicus	125-139
6337511-9	1983	The data indicate that the water intake of water-deprived rats can be divided into an angiotensin II-dependent component and angiotensin II-independent component.	Water	43-48	angiotensinogen	Rattus norvegicus	86-100
6337511-9	1983	The data indicate that the water intake of water-deprived rats can be divided into an angiotensin II-dependent component and angiotensin II-independent component.	Water	43-48	angiotensinogen	Rattus norvegicus	125-139
6306201-3	1983	Biologically and pharmacologically active components were extracted from the crude sap by means of water-acetone solution.	Water	99-104	amyloid P component, serum	Rattus norvegicus	83-86
6824944-1	1983	Chronic infusion of angiotensin II (ANG II) into the olfactory bulb (OB) elicited a moderate dipsogenesis which occurred only during the dark phase, essentially doubling the water-to-food intake ratio.	Water	174-179	angiotensinogen	Homo sapiens	36-42
24010174-3	1983	In addition, if these lesioned animals were water-deprived (48 h), the usual vasopressin release observed in sham-lesioned and normal controls was markedly blunted.	Water	44-49	arginine vasopressin	Rattus norvegicus	77-88
6824944-2	1983	Removal of the food from the ANG II-OB group reduced water consumption to the level of the saline-infused/food-deprived controls.	Water	53-58	angiotensinogen	Homo sapiens	29-35
6299195-1	1983	The interaction of solvent water protons with the bound paramagnetic metal ions of beef heart cytochrome c oxidase has been examined.	Water	27-32	cytochrome c, somatic	Homo sapiens	94-106
6625257-3	1983	min-1 with a correlation coefficient of 0.999 between measured and independently verified rates and amounts of water evaporation.	Water	111-116	CD59 molecule (CD59 blood group)	Homo sapiens	0-5
6412512-2	1983	When only the output of water in faeces, urine and vomit was taken into account the infants gained water (positive balance), 36.4 +/- 4.1 g/kg/day, with the given infusion.	Water	99-104	erythrocyte membrane protein band 4.1 like 2	Homo sapiens	134-139
6616568-0	1983	Changes in hypothalamic and extra-hypothalamic vasopressin content of water-deprived rats.	Water	70-75	arginine vasopressin	Rattus norvegicus	47-58
6824960-0	1983	Effects of yohimbine and tolazoline on isoproterenol and angiotensin II-induced water intake in rats.	Water	80-85	angiotensinogen	Rattus norvegicus	57-71
6824960-4	1983	Thus, the enhancing effect of these alpha 2-adrenoreceptor antagonists on isoproterenol- and angiotensin II-induced water intakes appears to be manifested peripherally, rather than centrally.	Water	116-121	angiotensinogen	Rattus norvegicus	93-107
6824960-5	1983	In view of the fact that clonidine, an alpha 2-adrenoreceptor agonist, has been shown to inhibit water intake induced by both isoproterenol and angiotensin II, the results suggest that the alpha 2-adrenoreceptor may play a role in modulating water intake induced by these two dipsogenic agents.	Water	97-102	angiotensinogen	Rattus norvegicus	144-158
6616568-3	1983	Pituitary VP decreased from 71.1 to 8.7 ng/mg, and plasma VP rose from 3.6 to 19.3 pg/ml during water deprivation.	Water	96-101	arginine vasopressin	Rattus norvegicus	58-60
6616568-5	1983	In extrahypothalamic sites VP-immunoreactivity in water-deprived rats was visibly reduced in periventricular thalamus and septum.	Water	50-55	arginine vasopressin	Rattus norvegicus	27-29
6668136-1	1983	Part II: The water-soluble vitamins B1, B2 and B6.	Water	13-18	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	36-49
6413439-7	1983	The application of RTPL detection techniques to the analysis of commercial PCN and PCB mixtures in surface water and urine is demonstrated.	Water	107-112	pyruvate carboxylase	Homo sapiens	83-86
6199539-1	1983	The effects of beta-endorphin and vasoactive intestinal peptide (VIP) on the body shaking response to ice water immersion were observed in anesthetized rats.	Water	106-111	vasoactive intestinal peptide	Rattus norvegicus	65-68
6410073-8	1983	The lack of change in the amount of membrane cholesterol indicates that the vasopressin-induced increase in transepithelial water permeability is not mediated by a change in cholesterol content of the apical membrane.	Water	124-129	arginine vasopressin	Homo sapiens	76-87
6601721-6	1983	These results, together with previous observations indicating that other small molecules (like urea) are excluded from the ADH-induced channel, might indicate that single-file water movement can occur through this structure.	Water	176-181	arginine vasopressin	Homo sapiens	123-126
6294273-1	1983	Vasopressin enhances osmotic water flow and sodium transport across the toad urinary bladder by mechanisms involving cyclic AMP and calcium.	Water	29-34	arginine vasopressin	Homo sapiens	0-11
6674655-0	1983	Conditions for secretion of vasopressin in pressor amounts in water-replete rats.	Water	62-67	arginine vasopressin	Rattus norvegicus	28-39
6674655-1	1983	Conditions for secretion of pressor amounts of vasopressin were sought in conscious, water-replete rats.	Water	85-90	arginine vasopressin	Rattus norvegicus	47-58
6297974-0	1982	The reaction of cytochrome c with [Fe(EDTA)(H2O)]-.	Water	44-48	cytochrome c, somatic	Homo sapiens	16-28
6665043-3	1983	This communication reports our study of the NMR relaxation times, T1 and T2 of water protons in aqueous solutions of bovine serum albumin, gelatin, polyvinylpyrrolidone, poly(ethylene oxide), and polyvinylmethylether over a wide concentration range.	Water	79-84	albumin	Homo sapiens	124-137
6648028-5	1983	For comparison, oral water loading and 24-hour dehydration were used to suppress and stimulate endogenous vasopressin secretion in Long-Evans (LE) rats, and the effects on urine osmolality and IPC were examined.	Water	21-26	arginine vasopressin	Rattus norvegicus	106-117
6346673-1	1983	17 mineral water on insulin, histamine and pentagastrin stimulated gastric secretion].	Water	11-16	insulin	Homo sapiens	20-27
6758112-2	1982	Vasopressin levels of only 1-2 pg/ml are capable of decreasing substantially renal water excretion.	Water	83-88	arginine vasopressin	Homo sapiens	0-11
6984343-2	1982	A mild attack of this membrane by a polyoxyethylene nonylphenyl detergent, which reversibly depressed ADH-induced water permeability, has been found to modify aggregate structure while extracting additional proteins.	Water	114-119	arginine vasopressin	Homo sapiens	102-105
6758112-8	1982	A knowledge of clinical conditions associated with vasopressin-mediated water retention may have therapeutic implications as well.	Water	72-77	arginine vasopressin	Homo sapiens	51-62
6758112-9	1982	Thus, in recent years it has become appreciated that selected pharmacologic agents such as lithium and demeclocycline can impair the water retaining property of vasopressin [26].	Water	133-138	arginine vasopressin	Homo sapiens	161-172
7142181-2	1982	The subcellular distribution of rat erythrocyte NADH-cytochrome b5 reductase was determined by radioimmunoassay, using a rabbit antibody against the cathepsin D cleaved water-soluble fragment of rat liver microsomal reductase (I-reductase), which is known to be immunologically similar to the red cell enzyme.	Water	169-174	cathepsin D	Rattus norvegicus	149-160
7173713-4	1982	A direct effect on the mucosal cells and/or a ganglionic inhibition of intramural VIP-releasing neurons is suggested as a possible mechanism for the alpha-adrenergic increase of the net water absorption rate.	Water	186-191	vasoactive intestinal peptide	Homo sapiens	82-85
7162034-0	1982	Effect of arginine vasopressin antagonist on renal water excretion in glucocorticoid and mineralocorticoid deficient rats.	Water	51-56	arginine vasopressin	Rattus norvegicus	19-30
6892351-3	1982	Using mice, preference for barbital or ethanol solution was examined in choice test between drug solution and tap water after pretreatment with the drugs for 6, 15 or 30 days under different conditions, a) forcedly given the drug solution as drinking liquid.	Water	114-119	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	110-113
7137381-4	1982	Progressive increases in urine flow and decreases in urine osmolality and free water reabsorption occurred in vasopressin-treated animals.	Water	79-84	arginine vasopressin	Rattus norvegicus	110-121
17791587-1	1982	Fog water collected at three sites in Los Angeles and Bakersfield, California, was found to have higher acidity and higher concentrations of sulfate, nitrate, and ammonium than previously observed in atmospheric water droplets.	Water	4-9	zinc finger protein, FOG family member 1	Homo sapiens	0-3
17791587-1	1982	Fog water collected at three sites in Los Angeles and Bakersfield, California, was found to have higher acidity and higher concentrations of sulfate, nitrate, and ammonium than previously observed in atmospheric water droplets.	Water	212-217	zinc finger protein, FOG family member 1	Homo sapiens	0-3
17791587-2	1982	The pH of the fog water was in the range of 2.2 to 4.0.	Water	18-23	zinc finger protein, FOG family member 1	Homo sapiens	14-17
17791587-3	1982	The dominant processes controlling the fog water chemistry appear to be the condensation and evaporation of water vapor on preexisting aerosol and the scavenging of gas-phase nitric acid.	Water	43-48	zinc finger protein, FOG family member 1	Homo sapiens	39-42
17791587-3	1982	The dominant processes controlling the fog water chemistry appear to be the condensation and evaporation of water vapor on preexisting aerosol and the scavenging of gas-phase nitric acid.	Water	108-113	zinc finger protein, FOG family member 1	Homo sapiens	39-42
6814265-0	1982	Requirement of Na+ and K+ for the action of antidiuretic hormone on water permeability.	Water	68-73	arginine vasopressin	Homo sapiens	44-64
6814265-1	1982	Previous reports have shown that in the toad bladder the absence of serosal Na+ or K+ inhibits the action of antidiuretic hormone (ADH) on the osmotic permeability (Pf) but not on diffusional permeability (PDW) to water.	Water	214-219	arginine vasopressin	Homo sapiens	109-129
6814265-1	1982	Previous reports have shown that in the toad bladder the absence of serosal Na+ or K+ inhibits the action of antidiuretic hormone (ADH) on the osmotic permeability (Pf) but not on diffusional permeability (PDW) to water.	Water	214-219	arginine vasopressin	Homo sapiens	131-134
6814265-9	1982	Therefore, their presence in the serosa is essential for a full effect of ADH on the permeability to water of the apical membrane.	Water	101-106	arginine vasopressin	Homo sapiens	74-77
6814904-3	1982	However, the PCB levels in several species of fresh-water fish have raised concern about the PCB residues from environmental contamination, and it is this concern which has prompted a reassessment of the human risk involved from consumption of such fish.	Water	52-57	pyruvate carboxylase	Homo sapiens	13-16
7167403-3	1982	Boiling water extracts of pyloric antrum cross reacted with four antisera specific for the C-terminal region of gastrin or CCK, but estimates of concentration varied between antisera.	Water	8-13	cholecystokinin	Homo sapiens	123-126
7139045-1	1982	Nuclear magnetic relaxation measurements are reported as a function of field strength corresponding to the frequency range from 0.01 to 20 MHz for water protons in monoclinic lysozyme crystals at 278 and 298 K. Though the instrumentation used selects only a portion of the total magnetization to sample, the data clearly indicate a field dependence of the relaxation rate that signals the presence of slow motions characterized by time constants in the range of tenths of microseconds and slower.	Water	147-152	lysozyme	Homo sapiens	175-183
7156532-6	1982	The transpulmonary pressure (Ptp) threshold required for SAR activation was higher in the newborn than the adult for both tracheal (2.42 cm H2O vs 0.51 cm H2O) and bronchial 4.66 cm H2O vs 3.66 cm H2O) receptors.	Water	140-143	protein tyrosine phosphatase non-receptor type 13	Canis lupus familiaris	29-32
7156532-6	1982	The transpulmonary pressure (Ptp) threshold required for SAR activation was higher in the newborn than the adult for both tracheal (2.42 cm H2O vs 0.51 cm H2O) and bronchial 4.66 cm H2O vs 3.66 cm H2O) receptors.	Water	155-158	protein tyrosine phosphatase non-receptor type 13	Canis lupus familiaris	29-32
7156532-6	1982	The transpulmonary pressure (Ptp) threshold required for SAR activation was higher in the newborn than the adult for both tracheal (2.42 cm H2O vs 0.51 cm H2O) and bronchial 4.66 cm H2O vs 3.66 cm H2O) receptors.	Water	155-158	protein tyrosine phosphatase non-receptor type 13	Canis lupus familiaris	29-32
7156532-6	1982	The transpulmonary pressure (Ptp) threshold required for SAR activation was higher in the newborn than the adult for both tracheal (2.42 cm H2O vs 0.51 cm H2O) and bronchial 4.66 cm H2O vs 3.66 cm H2O) receptors.	Water	155-158	protein tyrosine phosphatase non-receptor type 13	Canis lupus familiaris	29-32
7155749-1	1982	Mice that had been given either tap water or 2 ppm lead in their drinking water and either severely food deprived (3 days before testing) or allowed food ad libitum demonstrated significant interactions of lead treatment by day by food condition and lead by block.	Water	36-41	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	32-35
7126621-2	1982	This paper confirms and extends the previous observation that colipase and bile salts stabilize pancreatic lipase against inactivation at its water/substrate interface.	Water	142-147	colipase	Homo sapiens	62-70
7177315-1	1982	Various clinical disorders of water and electrolytes metabolism were reported in relation to decrease or increase of the plasma anti-diuretic hormone (ADH), however, the estimated ADH value was not infrequently found inconsistent with clinical features.	Water	30-35	arginine vasopressin	Homo sapiens	151-154
7177315-1	1982	Various clinical disorders of water and electrolytes metabolism were reported in relation to decrease or increase of the plasma anti-diuretic hormone (ADH), however, the estimated ADH value was not infrequently found inconsistent with clinical features.	Water	30-35	arginine vasopressin	Homo sapiens	180-183
7178184-3	1982	Injected by intracerebroventricular route crinia-angiotensin II proved to be as active as angiotensin II in eliciting water intake in pigeons, while being less effective in rats.	Water	118-123	angiotensinogen	Rattus norvegicus	49-63
7178184-3	1982	Injected by intracerebroventricular route crinia-angiotensin II proved to be as active as angiotensin II in eliciting water intake in pigeons, while being less effective in rats.	Water	118-123	angiotensinogen	Rattus norvegicus	90-104
7138814-4	1982	The deuterium isotope effect on the lifetime of the Eu(III)-prothrombin complex and the Eu(III)-prothrombin-phospholipid complex was used to determine the number of water molecules coordinated to the Eu(III).	Water	165-170	coagulation factor II, thrombin	Homo sapiens	96-107
6810708-3	1982	However, ADH-induced diffusional permeability to tritiated water (PD) was enhanced by 17% with cytochalasin B.	Water	59-64	arginine vasopressin	Homo sapiens	9-12
7143552-1	1982	The effect of ethacrynic acid, bumetanide, frusemide, spironolactone and anti-diuretic hormone (ADH) on the urinary and faecal excretion of water and electrolytes by ponies was studied.	Water	140-145	arginine vasopressin	Homo sapiens	73-94
7129754-4	1982	The comparison of computed and experimental properties related to non radiative energy transfer of angiotensin II analogs, assuming that an ensemble of conformers is a satisfactory representation of the state of these molecules in water, provides further support for the model.	Water	231-236	angiotensinogen	Homo sapiens	99-113
6289928-0	1982	Model for the adsorption of cytochrome c at the water-mercury interface.	Water	48-53	cytochrome c, somatic	Homo sapiens	28-40
7050726-1	1982	Injection of angiotensin II (AII) into the cerebral ventricles at doses as low as 1 pmol h-1 results in a marked stimulation of salt and water ingestion in the rat.	Water	137-142	angiotensinogen	Rattus norvegicus	13-27
7133357-0	1982	Brain water accumulation after the central administration of vasopressin.	Water	6-11	arginine vasopressin	Homo sapiens	61-72
7133357-1	1982	The intraventricular administration of vasopressin or DDAVP (desmopressin acetate) increased the brain water content from 78.2% to 79.2-79.5%.	Water	103-108	arginine vasopressin	Homo sapiens	39-59
6294630-1	1982	The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel.	Water	107-112	cholecystokinin	Gallus gallus	22-49
6294630-1	1982	The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel.	Water	107-112	cholecystokinin	Gallus gallus	51-54
6124042-1	1982	Gas-phase, water-soluble components of cigarette smoke cause delayed fibrin self-assembly and prevent fibrin cross-linking by inactivation of factor XIIIa (plasma transglutaminase).	Water	11-16	coagulation factor XIII A chain	Homo sapiens	142-154
7050726-1	1982	Injection of angiotensin II (AII) into the cerebral ventricles at doses as low as 1 pmol h-1 results in a marked stimulation of salt and water ingestion in the rat.	Water	137-142	angiotensinogen	Rattus norvegicus	29-32
7138504-1	1982	Treatment of human immunoglobulin G, albumin and fibronectin with water-soluble carbodi-imide at pH4.75 in the presence of glycine ethyl ester resulted in an avid binding of (125)I-labelled native fibrinectin to the modified proteins.	Water	66-71	fibronectin 1	Homo sapiens	49-60
6291584-0	1982	Cytochrome c is cross-linked to subunit II of cytochrome c oxidase by a water-soluble carbodiimide.	Water	72-77	cytochrome c, somatic	Homo sapiens	0-12
6291584-0	1982	Cytochrome c is cross-linked to subunit II of cytochrome c oxidase by a water-soluble carbodiimide.	Water	72-77	cytochrome c, somatic	Homo sapiens	46-58
6818357-4	1982	In rats pretreated with phenobarbital (0.05%), Zn (10 mg/l) and Cu (10 mg/l) in tap water and cysteine (200 mg/kg s.c.), fetal toxicity of ASA was reduced, whereas it was enhanced in rats pretreated with SKF-525A (200 mg/kg s.c.) and alpha-naphthyl acetic acid (200 mg/kg p.o.)	Water	84-89	nuclear RNA export factor 1	Rattus norvegicus	80-83
6295751-5	1982	More prolonged elevation of plasma AVP levels by water restriction for 48 h, on the other hand, increased the responsiveness by 38 to 81%, which was restored to basal levels by ad libitum intake of water for another 48 h (positive feedback regulation).	Water	49-54	arginine vasopressin	Rattus norvegicus	35-38
6295751-5	1982	More prolonged elevation of plasma AVP levels by water restriction for 48 h, on the other hand, increased the responsiveness by 38 to 81%, which was restored to basal levels by ad libitum intake of water for another 48 h (positive feedback regulation).	Water	198-203	arginine vasopressin	Rattus norvegicus	35-38
6288601-2	1982	The citraconyl derivative of peptide I was coupled to either a model tetrapeptide or bovine serum albumin by reaction with silver nitrate/N-hydroxysuccinimide in water.	Water	162-167	albumin	Homo sapiens	92-105
7135425-1	1982	Administration of ethanol in the drinking water increases hepatic cytochrome P-450 content and xenobiotic metabolism.	Water	42-47	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-82
7135425-3	1982	Chronic consumption of ethanol (15% solution in the drinking water) increased hepatic cytochrome P-450 content as well as ethoxycoumarin-O-deethylase, aniline hydroxylase and benzphetamine-N-demethylase activities.	Water	61-66	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	86-102
7084115-3	1982	However, the induction of VP release caused by the addition of NaCl (sufficient to yield a 10 mosmol/kg H2O increase in culture medium osmolality) was not reduced by NE in concentrations as high as 10(-5) M. An alpha-adrenergic receptor mediation of the inhibition of VP release by NE was suggested by the ability of phentolamine and phenoxybenzamine, but not propranolol, to block this effect.	Water	104-107	arginine vasopressin	Rattus norvegicus	26-28
6809486-0	1982	Inhibitory effects of 1-iodo-3-aminomethyl-5,6,7,8-tetrahydro-2-naphthol (ONO-3122) and prostaglandin H2 on vasopressin-induced osmotic water flow in toad bladder.	Water	136-141	arginine vasopressin	Homo sapiens	108-119
6281255-6	1982	In a first attempt to test this model, carboxyl groups of cytochrome c peroxidase have been modified with a water-soluble carbodiimide, either alone or in combination with a nucleophile.	Water	108-113	cytochrome c, somatic	Homo sapiens	58-70
7076803-1	1982	The presence of PRL in high concentration in human amniotic fluid has been related to changes in water transport across amnion but not chorion leave.	Water	97-102	prolactin	Homo sapiens	16-19
7104311-6	1982	Trehalase thus catalyzes two stereocomplementary types of glycosylation reactions: (I) alpha-D-glucosyl fluoride (or alpha, alpha-trehalose) + H2O leads to beta-D-glucose + HF (or alpha-D-glucose); (II) beta-D-glucosyl fluoride + alpha-D-glucopyranose leads to alpha, alpha-trehalose + HF.	Water	143-146	trehalase	Oryctolagus cuniculus	0-9
7113593-3	1982	Ethanol anaesthesia and water loading in Long Evans suppressed plasma vasopressin levels and was associated with an antidiuretic response to oxytocin.	Water	24-29	arginine vasopressin	Rattus norvegicus	70-81
6809042-5	1982	Complete unfolding of the alpha helix and subsequent desorption of the apo A-I molecules from the lipid/water interface involve cooperative exposure of these apolar residues to the aqueous phase.	Water	104-109	apolipoprotein A1	Homo sapiens	71-78
6280982-6	1982	When separated zones of HFA tissue were maintained in culture in the presence or absence of ACTH, the rates of de novo synthesis, as determined by the rate of incorporation of tritium from [3H]water into cholesterol, were stimulated to a similar extent by ACTH in both fetal zone and neocortex tissues.	Water	193-198	proopiomelanocortin	Homo sapiens	92-96
7091310-5	1982	Water injection decreased serum AVP in diabetics (as in normals), but only to 5.8 +/- 1.0 pg/ml.	Water	0-5	arginine vasopressin	Rattus norvegicus	32-35
6282650-2	1982	Neuropeptide diuretic hormones (DH), possibly related to vasopressin, stimulate tubular fluid secretion by 2- to 200-fold in response to water loading, e.g., feeding.	Water	137-142	arginine vasopressin	Homo sapiens	57-68
7128544-0	1982	Free water excretion due to suppressed vasopressin and stimulated aldosterone during sodium restriction in hypoaldosteronemic renal failure.	Water	5-10	arginine vasopressin	Homo sapiens	39-50
7128544-4	1982	Paradoxical enhancement of water excretion was explained by increased delivery of filtrate into the distal nephron, increased abstraction of Na from the tubular fluid together with insufficient water permeability of the collecting tubules and lowered vasopressin production.	Water	27-32	arginine vasopressin	Homo sapiens	251-262
6287253-3	1982	The hepatoma cells metabolized about 90% of 5 microM benzo[a]pyrene into water-soluble products within 24 h. Aryl hydrocarbon hydroxylase activity in huH-1 cells was induced to 24 times higher than the basal level by treatment with 13 microM benz[a]anthracene for 24 h. Metabolic activation of benzo[a]pyrene, dimethylnitrosamine and aflatoxin B1 by huH-1 cells was observed by cell-mediated sister-chromatid exchange assay.	Water	73-78	chloride intracellular channel 4	Homo sapiens	150-155
6284205-6	1982	These studies of the binding of peroxide clarify the mechanism by which cytochrome c oxidase catalyzes the reduction of oxygen to water without the formation of free-radical intermediates.	Water	130-135	cytochrome c, somatic	Homo sapiens	72-84
6125252-0	1982	Effect of somatostatin on renal water handling in the dog.	Water	32-37	somatostatin	Canis lupus familiaris	10-22
6279499-7	1982	In dogs with aldosterone hypertension, the changes in salt and water balance produced by ACTH were comparable to those that occurred when ACTH was administered to dogs with NE hypertension.	Water	63-68	proopiomelanocortin	Canis lupus familiaris	89-93
6280929-1	1982	Previous studies have suggested that ectopic production of adrenocorticotropic hormone (ACTH) or antidiuretic hormone (ADH) may occur commonly in patients with small cell carcinoma of the lung (SCCL) and that evidence of such production may be elicited only by provocative tests of water excretion and adrenal function.	Water	282-287	arginine vasopressin	Homo sapiens	97-117
6280929-1	1982	Previous studies have suggested that ectopic production of adrenocorticotropic hormone (ACTH) or antidiuretic hormone (ADH) may occur commonly in patients with small cell carcinoma of the lung (SCCL) and that evidence of such production may be elicited only by provocative tests of water excretion and adrenal function.	Water	282-287	arginine vasopressin	Homo sapiens	119-122
6280929-4	1982	The possibility of ectopic ADH secretion was assessed by a standard water loading test, which showed excretion impairment in 60 percent of patients with SCCL and 68 percent of patients with other cancers (P greater than 0.9).	Water	68-73	arginine vasopressin	Homo sapiens	27-30
6286079-2	1982	Injections of 12.5 pM of angiotensin II elicited water intakes averaging 10 mL in 15 min with latencies of less than 3 min.	Water	49-54	angiotensinogen	Rattus norvegicus	25-39
6284265-6	1982	Instead, the decrease in k in alcohol/water mixtures is best explained--in conformity with Onsager"s theory of the reaction field--by a polarity effect on the dipole moment of the cytochrome c heme upon diffusion of the polar solvent molecules into the low dielectric constant heme crevice.	Water	38-43	cytochrome c, somatic	Homo sapiens	180-192
7046164-7	1982	In addition to potent in vitro immunosuppressive properties, supplementation of drinking water with BA or PA resulted in prolongation of full-thickness skin grafts in DBA/2 (H-2d) to C57BL/6 (H-2b) donor-recipient combinations.	Water	89-94	DBA2	Homo sapiens	167-172
6808461-0	1982	Effect of hydrostatic pressure on ADH induced osmotic water flow in toad bladder.	Water	54-59	arginine vasopressin	Homo sapiens	34-37
6808461-1	1982	The effect of hydrostatic pressure (HP) on antidiuretic hormone (ADH) stimulated osmotic water flow (Jv) across the toad urinary bladder was evaluated.	Water	89-94	arginine vasopressin	Homo sapiens	43-63
6808461-1	1982	The effect of hydrostatic pressure (HP) on antidiuretic hormone (ADH) stimulated osmotic water flow (Jv) across the toad urinary bladder was evaluated.	Water	89-94	arginine vasopressin	Homo sapiens	65-68
6808461-2	1982	Jv for ADH-stimulated bladders was significantly reduced by an elevation of the serosal HP gradient to 1 cm H2O.	Water	108-111	arginine vasopressin	Homo sapiens	7-10
6808461-6	1982	The reduction in ADH-associated Jv with serosal HP was apparently caused by a back-flux of water through a paracellular pathway.	Water	91-96	arginine vasopressin	Homo sapiens	17-20
6808461-8	1982	The results suggest a specific sensitivity of a paracellular pathway to a small serosal HP gradient in bladders with ADH-stimulated water flow.	Water	132-137	arginine vasopressin	Homo sapiens	117-120
6954553-2	1982	Water loading promptly increased urinary excretion of PGE as well as urine flow rate and decreased urine osmolality (all p less than 0.001), but did not affect urinary excretions of sodium, potassium and creatinine, plasma renin activity and plasma aldosterone concentration.	Water	0-5	renin	Homo sapiens	223-228
6278038-0	1982	Alterations in renal tubular water transport induced by parathyroid hormone: evidence for both antidiuretic hormone-mediated and independent effects.	Water	29-34	parathyroid hormone	Homo sapiens	56-75
7065556-4	1982	Mean plasma arginine vasopressin values after water load were significantly higher in Group 1 (1.34 +/- 0.36 pg/mL) than in Group 2 (undetectable).	Water	46-51	arginine vasopressin	Homo sapiens	21-32
7096284-0	1982	Calorimetric study on thermal denaturation of lysozyme in polyol-water mixtures.	Water	65-70	lysozyme	Homo sapiens	46-54
7072743-6	1982	Moreover, markedly increased ADH values (range 1.1 to 13.0 pg/ml) were often encountered in patients with acute respiratory failure despite significant hyposmolality (263 to 275 mOsm/kg H2O).	Water	186-189	arginine vasopressin	Homo sapiens	29-32
7072743-8	1982	These results suggest that patients with acute respiratory failure are susceptible to water retention and hyposmolality due to nonosmotic release of antidiuretic hormone.	Water	86-91	arginine vasopressin	Homo sapiens	149-169
7044934-0	1982	Interaction between effects of insulin and vasopressin on renal excretion of water and sodium in rats.	Water	77-82	arginine vasopressin	Rattus norvegicus	43-54
7134864-0	1982	Preparation of 125I-labeled gastric inhibitory polypeptide, using water-insoluble 1,2,4,6-tetrachloro-3 alpha,6 alpha-diphenylglycoluril (Iodo-gen) as the oxidizing agent.	Water	66-71	gastric inhibitory polypeptide	Rattus norvegicus	28-58
7078362-8	1982	It is suggested that the water-conserving effect of vasopressin 1 day after the dietary change was suppressed by the very high PGE2 production, resulting in normal renal water excretion.	Water	25-30	arginine vasopressin	Rattus norvegicus	52-63
7078362-8	1982	It is suggested that the water-conserving effect of vasopressin 1 day after the dietary change was suppressed by the very high PGE2 production, resulting in normal renal water excretion.	Water	170-175	arginine vasopressin	Rattus norvegicus	52-63
7120025-2	1982	In water-loaded rats, vasopressin induced a dose-related increase in total urinary prostaglandin E and prostaglandin F excretion and a decrease in total urine output.	Water	3-8	arginine vasopressin	Rattus norvegicus	22-33
7057195-1	1982	Angiotensin II-like immunoreactivity was extracted from brains of bilaterally nephrectomized rats with several different extraction procedures (90% methanol, distilled water, 6 M urea, 0.1 N HCl, and 2 M acetic acid).	Water	168-173	angiotensinogen	Rattus norvegicus	0-14
7039765-2	1982	Angiotensin I (ANG I), ANG II, ANG III and C-terminal hexa-, penta, tetra- and tripeptide stimulated water intake in water-replete rats and induced significant pressor responses.	Water	101-106	angiotensinogen	Rattus norvegicus	23-29
7039765-2	1982	Angiotensin I (ANG I), ANG II, ANG III and C-terminal hexa-, penta, tetra- and tripeptide stimulated water intake in water-replete rats and induced significant pressor responses.	Water	117-122	angiotensinogen	Rattus norvegicus	23-29
6802291-5	1982	At the higher dose of the diuretic this fall in blood pressure correlated with weight loss, suggesting that when the diuretic-induced compensatory rise in angiotensin II is prevented by captopril the fall in blood pressure becomes dependent on loss of sodium and water.	Water	263-268	angiotensinogen	Homo sapiens	155-169
7092405-2	1982	route, produces a dose-dependent inhibition of water intake elicited by angiotensin II or water deprivation.	Water	47-52	angiotensinogen	Rattus norvegicus	72-86
6121047-4	1982	Water loading (10 ml/kg) and EKC (0.5 mg/kg) diminished plasma vasopressin levels equally 60 min after treatment.	Water	0-5	arginine vasopressin	Rattus norvegicus	63-74
6121047-10	1982	EKC also blocked vasopressin-stimulated water flow in the toad bladder, a model of the renal distal tubule and collecting duct.	Water	40-45	arginine vasopressin	Rattus norvegicus	17-28
6979120-7	1982	Thus, it has been supposed that the formation of large vacuoles in the granular cells may be associated with the increased water transport across the cell stimulated by ADH.	Water	123-128	arginine vasopressin	Homo sapiens	169-172
7099984-1	1982	Laser Raman spectra of bradykinin in water, deuterium oxide, and the solid phase were recorded.	Water	37-42	kininogen 1	Homo sapiens	23-33
7060566-2	1982	1H spectra at 270 MHz of zwitterionic Met-enkephalin pentapeptide (Tyr-Gly-Gly-Phe-Met) in (C2H3)2SO/water mixtures are reported and discussed in terms of solvent-induced conformational transitions.	Water	101-106	proopiomelanocortin	Homo sapiens	38-52
7036728-5	1982	A decrease in sodium and water delivery to the ascending limb or in NaCl reabsorption by the ascending limb will impair urinary diluting ability, as will the presence of ADH.	Water	25-30	arginine vasopressin	Homo sapiens	170-173
7060566-6	1982	A conformational transition of Met-enkephalin from the intramolecularly bonded to the unbonded one takes place at about 40 mol-% water in (C2H3)2SO, involving the Met-5 NH proton and the Tyr-Gly-Gly fragment.	Water	129-134	proopiomelanocortin	Homo sapiens	31-45
6274902-1	1982	gamma MSH-like, ACTH-like, and beta-endorphin-like immunoreactivities (gamma MSH-LI, ACTH-LI, and beta-endorphin-LI, respectively) were detected in water extracts of four human gastric antral mucosa.	Water	148-153	proopiomelanocortin	Homo sapiens	16-20
6801089-3	1982	Graded acidification of the serosal medial resulted in a progressive decline in vasopressin-stimulated water flow from 26.6 +/- 0.5 mg/min at pH 8.4 to 1.7 +/- 0.6 at pH 6.9.	Water	103-108	arginine vasopressin	Homo sapiens	80-91
6274902-1	1982	gamma MSH-like, ACTH-like, and beta-endorphin-like immunoreactivities (gamma MSH-LI, ACTH-LI, and beta-endorphin-LI, respectively) were detected in water extracts of four human gastric antral mucosa.	Water	148-153	proopiomelanocortin	Homo sapiens	31-45
6274902-1	1982	gamma MSH-like, ACTH-like, and beta-endorphin-like immunoreactivities (gamma MSH-LI, ACTH-LI, and beta-endorphin-LI, respectively) were detected in water extracts of four human gastric antral mucosa.	Water	148-153	proopiomelanocortin	Homo sapiens	85-89
6274902-1	1982	gamma MSH-like, ACTH-like, and beta-endorphin-like immunoreactivities (gamma MSH-LI, ACTH-LI, and beta-endorphin-LI, respectively) were detected in water extracts of four human gastric antral mucosa.	Water	148-153	proopiomelanocortin	Homo sapiens	98-112
6274902-2	1982	The concentrations of gamma MSH-LI, ACTH-LI, and beta-endorphin-LI in the boiling water extracts were 9.9 +/- 3.3, 6.2 +/- 1.8, and 3.9 +/- 1.3 ng/g (mean +/- SE), respectively.	Water	82-87	proopiomelanocortin	Homo sapiens	49-63
7185250-0	1982	"Water-preserving-hormone"-proposal for a new name for the antidiuretic hormone (vasopressin)	Water	1-6	arginine vasopressin	Homo sapiens	59-79
7071085-6	1982	Animals treated with cocaine had lower preference ratios than saline controls although both groups consumed more novel fluid than tap water.	Water	134-139	nuclear RNA export factor 1	Rattus norvegicus	130-133
6803786-0	1982	Mechanisms of hydroxylation by cytochrome P-450: exchange of iron-oxygen intermediates with water.	Water	92-97	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-47
7185250-0	1982	"Water-preserving-hormone"-proposal for a new name for the antidiuretic hormone (vasopressin)	Water	1-6	arginine vasopressin	Homo sapiens	81-92
6764737-1	1982	Here we have reviewed mainly the cerebral regulation of water intake and its relationship with the regulation of the water-retaining antidiuretic hormone (ADH).	Water	56-61	arginine vasopressin	Homo sapiens	133-153
7090924-1	1982	Human eosinophil peroxidase is a cationic protein with a higher content of arginine, the enzyme being poorly soluble in water.	Water	120-125	eosinophil peroxidase	Homo sapiens	6-27
6281092-3	1982	The urinary bladder cells released an inhibitor of ADH changing the reaction of receptors to ADH; adsorption of this inhibitor increased the water permeability after addition of ADH.	Water	141-146	arginine vasopressin	Homo sapiens	51-54
6281092-3	1982	The urinary bladder cells released an inhibitor of ADH changing the reaction of receptors to ADH; adsorption of this inhibitor increased the water permeability after addition of ADH.	Water	141-146	arginine vasopressin	Homo sapiens	93-96
6281092-3	1982	The urinary bladder cells released an inhibitor of ADH changing the reaction of receptors to ADH; adsorption of this inhibitor increased the water permeability after addition of ADH.	Water	141-146	arginine vasopressin	Homo sapiens	93-96
6758651-2	1982	It has been demonstrated through the use of new techniques that the action of vasopressin on the kidneys is not limited to changing the water permeability of distal tubules and collecting ducts.	Water	136-141	arginine vasopressin	Rattus norvegicus	78-89
6127053-0	1982	Multiplication of fluorescent pseudomonads at low substrate concentrations in tap water.	Water	82-87	USO1 vesicle transport factor	Homo sapiens	78-81
6764737-11	1982	Severe volume depletion may induce RAS hyperactivity to such an extent that generated angiotensin II stimulates the ADH release and water intake.	Water	132-137	angiotensinogen	Homo sapiens	86-100
6764737-1	1982	Here we have reviewed mainly the cerebral regulation of water intake and its relationship with the regulation of the water-retaining antidiuretic hormone (ADH).	Water	56-61	arginine vasopressin	Homo sapiens	155-158
6764737-1	1982	Here we have reviewed mainly the cerebral regulation of water intake and its relationship with the regulation of the water-retaining antidiuretic hormone (ADH).	Water	117-122	arginine vasopressin	Homo sapiens	133-153
6764737-1	1982	Here we have reviewed mainly the cerebral regulation of water intake and its relationship with the regulation of the water-retaining antidiuretic hormone (ADH).	Water	117-122	arginine vasopressin	Homo sapiens	155-158
7171721-1	1982	Absorption spectra of highly purified liver microsomal cytochrome P-450 in non-equilibrium states were obtained at 77 K by reduction with trapped electrons, formed by gamma-irradiation of the water-glycerol matrix.	Water	192-197	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	55-71
6282241-0	1982	The effects of fluoridated water on rat urine and tissue cAMP levels.	Water	27-32	cathelicidin antimicrobial peptide	Rattus norvegicus	57-61
6282241-6	1982	By week 4, the rats receiving the fluoridated water had significantly higher levels of cAMP in the liver (113 per cent) tibia (130 per cent), femur (89 per cent) and heart (35 per cent).	Water	46-51	cathelicidin antimicrobial peptide	Rattus norvegicus	87-91
7055905-3	1982	Volume displacements from addition of albumin or Intralipid to aqueous samples yielded the predicted lower flame-photometric results because of the relative decrease in sample water.	Water	176-181	albumin	Homo sapiens	38-45
6817966-6	1982	Treatment of muscle with water or phosphate solutions showed that all the carbonic anhydrase III was water extractable, whereas significant zinc remained bound, but was partially extractable by phosphate solutions.	Water	25-30	carbonic anhydrase 3	Homo sapiens	74-96
6754157-0	1982	Response of the renin-aldosterone system and antidiuretic hormone to oral water loading and hypertonic saline infusion during and after pregnancy.	Water	74-79	renin	Homo sapiens	16-21
6754157-2	1982	In this study the effect osmolar and water loading on the renin-angiotensin system and arginine vasopressin (AVP) secretion has been tested in seven women during the third trimester and again 8-10 weeks after delivery.	Water	37-42	renin	Homo sapiens	58-63
6754157-6	1982	Despite the decreased basal Posm of pregnancy, urinary AVP increased and decreased appropriately during osmolar and water loading.	Water	116-121	arginine vasopressin	Homo sapiens	55-58
6817966-6	1982	Treatment of muscle with water or phosphate solutions showed that all the carbonic anhydrase III was water extractable, whereas significant zinc remained bound, but was partially extractable by phosphate solutions.	Water	101-106	carbonic anhydrase 3	Homo sapiens	74-96
6124483-3	1982	Controls drank tap water.	Water	19-24	nuclear RNA export factor 1	Rattus norvegicus	15-18
6286976-0	1982	Dopaminergic inhibition of vasopressin-stimulated water flow in the toad bladder: evidence for local formation of dopamine.	Water	50-55	arginine vasopressin	Homo sapiens	27-38
7033291-4	1982	In boiling water extracts of duodenal mucosa from both groups a factor with the properties of the COOH-terminal octapeptide of cholecystokinin predominated, but there were also significant amounts of a larger molecular weight form.	Water	11-16	cholecystokinin	Homo sapiens	127-142
6808140-0	1982	Extracellular Ca2+ and the effect of antidiuretic hormone on the water permeability of the toad urinary bladder: an example of flow-induced alteration of flow.	Water	65-70	arginine vasopressin	Homo sapiens	37-57
6808140-1	1982	The extracellular Ca2+ requirement for antidiuretic hormone (ADH) stimulation of water permeability in the toad urinary bladder has been critically examine.	Water	81-86	arginine vasopressin	Homo sapiens	39-59
6808140-1	1982	The extracellular Ca2+ requirement for antidiuretic hormone (ADH) stimulation of water permeability in the toad urinary bladder has been critically examine.	Water	81-86	arginine vasopressin	Homo sapiens	61-64
7096899-3	1982	Ten rats from each group were killed at this time and the remaining animals were fed tap water for a further 90 days before they were sacrificed.	Water	89-94	nuclear RNA export factor 1	Rattus norvegicus	85-88
6808140-3	1982	Under these conditions, ADH-induced osmotic water flow was inhibited by more than 60% while enhancement of the diffusional permeability to water was unaffected.	Water	44-49	arginine vasopressin	Homo sapiens	24-27
7123007-5	1982	A dose-dependent response of water and electrolyte absorption to graded doses of pure CCK was observed, without concomitant inhibition of glucose absorption with lower doses.	Water	29-34	cholecystokinin	Homo sapiens	86-89
6808140-7	1982	Under certain conditions the ADH-effect on the tissue"s hydraulic permeability is probably best assessed by measurement of the diffusional permeability to water; although accuracy in this determination is difficult, it is not as strongly dependent on tissue geometry.	Water	155-160	arginine vasopressin	Homo sapiens	29-32
6290865-0	1982	Inhibition of prostaglandin synthesis antagonizes the colchicine-induced reduction of vasopressin-stimulated water flow in the toad urinary bladder.	Water	109-114	arginine vasopressin	Homo sapiens	86-97
6280212-1	1982	The effects of diazoxide and hydrochlorothiazide on vasopressin-induced increments in osmotic water flow and sodium transport across the frog bladder were studied.	Water	94-99	arginine vasopressin	Homo sapiens	52-63
6280212-2	1982	Diazoxide enhanced the vasopressin-induced osmotic water flow of the bladder, but did not affect the cyclic AMP- or theophylline-induced water flow.	Water	51-56	arginine vasopressin	Homo sapiens	23-34
6753486-2	1981	Plasma AVP was decreased following hydration with 10 ml of water (1.0 +/- 0.3 pg/ml, mean +/- S.E.M.)	Water	59-64	arginine vasopressin	Rattus norvegicus	7-10
7069622-12	1982	It is possible that altered renal haemodynamics are responsible for the reduced urinary water and solute excretion which occurs during acute prolactin administration.	Water	88-93	prolactin	Rattus norvegicus	141-150
6753486-3	1981	as compared to controls (6.1 +/- 2.0 pg/ml), while withdrawal of water for 48 hours stimulated AVP release (29 +/- 8 pg/ml).	Water	65-70	arginine vasopressin	Rattus norvegicus	95-98
6275715-5	1981	Addition of PGE1 (10(-7) M) and vasopressin inhibited water flow as compared with vasopressin along but increased the kinase ratio above that with vasopressin only.	Water	54-59	arginine vasopressin	Homo sapiens	32-43
7039733-5	1981	The MAR increases for the completely treated potable water.	Water	53-58	interferon regulatory factor 1	Homo sapiens	4-7
6275715-2	1981	Both water flow and activation of cAMP-kinase in response to vasopressin were enhanced after prostaglandin inhibition, consistent with inhibition of vasopressin-induced cAMP generation by endogenous prostaglandins.	Water	5-10	arginine vasopressin	Homo sapiens	61-72
6275715-2	1981	Both water flow and activation of cAMP-kinase in response to vasopressin were enhanced after prostaglandin inhibition, consistent with inhibition of vasopressin-induced cAMP generation by endogenous prostaglandins.	Water	5-10	arginine vasopressin	Homo sapiens	149-160
7337851-0	1981	Use of reverse phase C-18 minicolumns for concentrating water-soluble hydrocarbons.	Water	56-61	Bardet-Biedl syndrome 9	Homo sapiens	21-25
7188584-4	1981	Plasma concentrations of AVP were significantly elevated in DOCa hypertensive rats compared with normotensive control rats, whether or not they received 1% sodium chloride solution or demineralized water to drink.	Water	198-203	arginine vasopressin	Rattus norvegicus	25-28
7079557-8	1982	The data suggest that the effects of BK on renal handling of salt and water and on RPF are not mediated by either prostaglandins or beta receptors.	Water	70-75	kininogen 1	Canis lupus familiaris	37-39
7319871-0	1981	Effects of vasopressin administration on diuresis of water immersion in normal humans.	Water	53-58	arginine vasopressin	Homo sapiens	11-22
7030085-9	1981	These results indicate that the hypotensive effect of water restriction in the two-kidney one-clip hypertensive rat model may be mediated, at least in part, through elevated circulating levels of vasopressin that subsequently inhibit renin release.	Water	54-59	arginine vasopressin	Rattus norvegicus	196-207
7200137-10	1981	When prolactin secretion was inhibited with bromocriptine, there was a parallel fall in water intake and plasma prolactin levels in the experimental animals to the levels observed in the controls.	Water	88-93	prolactin	Rattus norvegicus	5-14
7284851-1	1981	Bilateral nephrectomy in the rats deprived of water for 46 h markedly reduced plasma angiotensin II concentrations (P less than 0.001), but it was without effect on extremely low levels of the hormone in the hypothalamic tissue.	Water	46-51	angiotensinogen	Rattus norvegicus	85-99
7316567-5	1981	day) and diatomaceous earth; a control group drank fiber-free well water or filtered city tap water.	Water	94-99	nuclear RNA export factor 1	Rattus norvegicus	90-93
6270309-3	1981	Osmotic water movements across N-ethylmaleimide-"fixed" vasopressin or cyclic AMP-stimulated bladders were likewise unchanged by fluoride, suggesting that fluoride is exerting an action subsequent to the endogenous formation of cyclic AMP but before the final effector mechanism.	Water	8-13	arginine vasopressin	Homo sapiens	56-67
7323209-0	1981	The effect of vasopressin in water-loaded hypokalemic patients is prostaglandin-independent.	Water	29-34	arginine vasopressin	Homo sapiens	14-25
7287710-7	1981	These findings lead to a view that the proton-catalyzed nucleophilic displacement of O2- from MbO2 by an entering water molecule, or SN2 mechanism with proton assistance, is the basis for most of the autoxidation reaction under normal conditions.	Water	114-119	solute carrier family 38 member 5	Homo sapiens	133-136
6892348-4	1981	Using automatic drinkometer the intake of drug solution from the paired sucking tube connected to tap water and/or drug solution was estimated.	Water	102-107	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	98-101
6169149-1	1981	Intraventricular administration of supraphysiological amounts of renin, nerve growth factor preparation, or angiotensin II greatly increased the consumption of water and hypertonic sodium bicarbonate solution by sheep.	Water	160-165	renin	Ovis aries	65-70
7308773-0	1981	[Experience with using a spectrophotometric method for NR-1 oil solvent in water].	Water	75-80	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	55-59
6271058-3	1981	Kinetics of inactivation of poliovirus type 2 by chlorine and CAT in chlorine demand-free water were investigated by using a kinetic apparatus.	Water	90-95	catalase	Homo sapiens	62-65
7284228-3	1981	Air samples could be aspirated into the collection bag at flow rates of as low as 1 ml min-1 by allowing the water to drain from the cylinder at a controlled rate.	Water	109-114	CD59 molecule (CD59 blood group)	Homo sapiens	87-92
6114014-9	1981	The hepatic transport of bile acid, and the water and electrolyte secretion are directly affected by somatostatin, and the experimentally-induced cholestasis seems a new and suitable model for studying mechanisms of bile secretion.	Water	44-49	somatostatin	Rattus norvegicus	101-113
6273835-0	1981	[Use water-soluble and lipid-bound forms of cytochrome C for the treatment of experimental hemorrhagic shock].	Water	5-10	cytochrome c, somatic	Homo sapiens	44-56
7324613-1	1981	The incidence of nine water-related diseases in the Brak oases of the Sahara desert, before and after the installation of water treatment plants, are reported.	Water	22-27	C-X-C motif chemokine ligand 14	Homo sapiens	52-56
7325893-7	1981	Deprivation of water, which also reduces food intake, for 12, 18 and 24 h markedly reduced plasma concentrations of SLA but had no effect on plasma GH concentration in Thornber cockerels.	Water	15-20	Src like adaptor	Gallus gallus	116-119
7026126-0	1981	Water and electrolyte composition of urine and ileal fluid and its relationship to renin and aldosterone during dietary sodium deprivation in patients with ileostomies.	Water	0-5	renin	Homo sapiens	83-88
6272020-1	1981	Coincident with an increase in water permeability, the ridge-like surface structures of toad bladder granular cells transform to individual microvilli after stimulation with vasopressin (VP) or cyclic adenosine monophosphate (cAMP) by a mechanism that is yet to be defined.	Water	31-36	arginine vasopressin	Homo sapiens	174-185
7263712-2	1981	The solid state conformational analysis of Ac-D-Ala-D-Ala-OH.H2O, carried out by infrared absorption and X-ray diffraction, has indicated that the molecules are not extended in a regular beta conformation, but rather that they are partially folded, the phi, psi torsional angles of the COOH-terminal residue in particular being in the region of the left-handed alpha helix of the Ramachandran map.	Water	61-64	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	43-47
7284368-0	1981	Nocodazole inhibition of the vasopressin-induced water permeability increase in toad urinary bladder.	Water	49-54	arginine vasopressin	Homo sapiens	29-40
7284368-6	1981	These data support the view that microtubules are involved in the vasopressin-induced increase in water permeability in toad bladder and also indicate that this involvement is limited to the period prior to or directly after stimulation.	Water	98-103	arginine vasopressin	Homo sapiens	66-77
7296394-2	1981	When Ca2+ was released iontophoretically, the amplitude and time course of the resultant increase in extracellular ca2+ concentration could be fitted to a simple diffusion model, but the apparent diffusion coefficient of Ca2+ was only about 1/100 of its value in water, possibly because of reversible Ca/+ binding to hippocampal tissue.	Water	263-268	carbonic anhydrase 2	Rattus norvegicus	5-8
7296394-2	1981	When Ca2+ was released iontophoretically, the amplitude and time course of the resultant increase in extracellular ca2+ concentration could be fitted to a simple diffusion model, but the apparent diffusion coefficient of Ca2+ was only about 1/100 of its value in water, possibly because of reversible Ca/+ binding to hippocampal tissue.	Water	263-268	carbonic anhydrase 2	Rattus norvegicus	115-118
7326874-9	1981	The results suggest that vasopressin is not essential for the development of renal hypertension but the absolute levels of blood pressure achieved in 1K-1C hypertension are volume-dependent and thus influenced by the water-retaining properties of vasopressin.	Water	217-222	arginine vasopressin	Rattus norvegicus	247-258
6281205-2	1981	The alpha-helix content of human beta-endorphin (beta h-EP) has been determined by circular dichroism (CD) in solutions ranging from 0 to 95% methanol in water.	Water	154-159	proopiomelanocortin	Homo sapiens	33-47
7263837-2	1981	Endogenous ADH was increased by water deprivation.	Water	32-37	arginine vasopressin	Homo sapiens	11-14
7289572-0	1981	[Blood fibrinogen during 7-day water immersion and short-term space flight].	Water	31-36	fibrinogen beta chain	Homo sapiens	7-17
7291237-8	1981	The increase in water intake in CLA rats appears to be partly mediated by angiotensin II.	Water	16-21	angiotensinogen	Rattus norvegicus	74-88
7342328-0	1981	Health and nutritional problems in the NAM Pong water resource development scheme.	Water	48-53	SH3 and cysteine rich domain 3	Homo sapiens	39-42
7272330-3	1981	Serum albumin, which itself has a surface tension of congruent to 70.3 erg/cm2, when dissolved in water lowers the surface tension of water from 72.5 to congruent to 50 erg/cm2, as measured by a variety of means, including the pendant drop, the Wilhelmy plate and the platinum ring methods.	Water	98-103	albumin	Homo sapiens	0-13
7272330-3	1981	Serum albumin, which itself has a surface tension of congruent to 70.3 erg/cm2, when dissolved in water lowers the surface tension of water from 72.5 to congruent to 50 erg/cm2, as measured by a variety of means, including the pendant drop, the Wilhelmy plate and the platinum ring methods.	Water	134-139	albumin	Homo sapiens	0-13
7020879-9	1981	This resulted in the formation of angiotensin I from endogenous brain angiotensinogen, in the stimulation of water uptake, and in a long-lasting increase of arterial blood pressure.	Water	109-114	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	34-47
6892348-7	1981	In the choice test between tap water and drug solution, mice can distinguish the concentration of drug solution and avoid it in high concentrations.	Water	31-36	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	27-30
6115584-2	1981	Somatostatin, whether applied topically to the duodenal mucosa or given intravenously, resulted in qualitatively similar inhibition of pancreatic secretion of water, bicarbonate, and enzyme protein, being about four to eight times less potent after intraduodenal than after intravenous administration.	Water	159-164	somatostatin	Canis lupus familiaris	0-12
7257701-0	1981	The effects of water deprivation and water loading during treatment with 1-deamino-8-D-arginine vasopressin in central diabetes insipidus in childhood.	Water	15-20	arginine vasopressin	Homo sapiens	96-107
16725628-8	1981	However, alterations in water intake and thermoregulation of stressed cows were associated with decreased fertility and milk production, and changes in steroid concentrations that may reduce uterine blood flow.	Water	24-29	Weaning weight-maternal milk	Bos taurus	120-124
7021994-4	1981	Immersion in a water-bath or beta-blockade reduced the increase of plasma renin concentration after F but not after EA.	Water	15-20	renin	Homo sapiens	74-79
7257701-0	1981	The effects of water deprivation and water loading during treatment with 1-deamino-8-D-arginine vasopressin in central diabetes insipidus in childhood.	Water	37-42	arginine vasopressin	Homo sapiens	96-107
7287687-0	1981	Preferential hydration of bovine serum albumin in polyhydric alcohol-water mixtures.	Water	69-74	albumin	Homo sapiens	33-46
7018268-6	1981	Conversely, 6- or 48-h access to tap water did not increase RCRC of previously Na-loaded rats, but did increase severity of ARF.	Water	37-42	nuclear RNA export factor 1	Rattus norvegicus	33-36
6270658-3	1981	Peptide Ia was coupled to another synthetic peptide, [Lys(Cit)19,24,28,29]-beta-endorphin-(18-31), by reaction with silver nitrate--N-hydroxysuccinimide in water.	Water	156-161	proopiomelanocortin	Homo sapiens	75-89
7272284-3	1981	Apolipoprotein B does not interact with lipid vesicles but rather binds a small number of phospholipid molecules in water-soluble form.	Water	116-121	apolipoprotein B	Homo sapiens	0-16
7324506-3	1981	Following the administration of the aminoglycoside gentamicin to rats for five days, a decrease in concentrating ability was demonstrated, caused by impaired vasopressin-mediated water transport.	Water	179-184	arginine vasopressin	Rattus norvegicus	158-169
7291218-3	1981	Drinking was also reduced by the two drugs in 24 hr water-deprived heterozygotes, which have detectable levels of vasopressin.	Water	52-57	arginine vasopressin	Rattus norvegicus	114-125
7018256-9	1981	In addition to the direct antagonistic effect on vasopressin-dependent osmotic water flow across the collecting tubule, prostaglandins and vasopressin may have antagonistic effects at other sites.	Water	79-84	arginine vasopressin	Homo sapiens	49-60
7293923-6	1981	For an inspiratory flow rate of 30 L min-1, the total deposition efficiency of H2SO4-and-H2O droplets, resulting from water condensation upon H2SO4 particles of initial geometric diameter D0, is greater than inspired nonhygroscopic particles of identical aerodynamic diameter when D0 greater than 0.1 mu m. The opposite is found when D0 less than 0.1 mu m. The effects of hygroscopic growth are explained in terms of the changing deposition efficiencies of the inertial impaction, sedimentation and diffusion mechanisms.	Water	89-92	CD59 molecule (CD59 blood group)	Homo sapiens	37-42
7293923-6	1981	For an inspiratory flow rate of 30 L min-1, the total deposition efficiency of H2SO4-and-H2O droplets, resulting from water condensation upon H2SO4 particles of initial geometric diameter D0, is greater than inspired nonhygroscopic particles of identical aerodynamic diameter when D0 greater than 0.1 mu m. The opposite is found when D0 less than 0.1 mu m. The effects of hygroscopic growth are explained in terms of the changing deposition efficiencies of the inertial impaction, sedimentation and diffusion mechanisms.	Water	118-123	CD59 molecule (CD59 blood group)	Homo sapiens	37-42
7259690-1	1981	We hypothesize that hemodilution in the early stages of water immersion plays an important role in vasopressin (AVP) suppression and subsequent diuresis.	Water	56-61	arginine vasopressin	Homo sapiens	99-110
6165739-0	1981	Role of the endogenous kallikrein-kinin system in modulating vasopressin-stimulated water flow and urea permeability in the toad urinary bladder.	Water	84-89	arginine vasopressin	Homo sapiens	61-72
6165739-3	1981	Kinin potentiation by the kininase II inhibitor captopril (SQ 14225) significantly decreased vasopressin and 8-Br-cAMP-stimulated water flow.	Water	130-135	angiotensin I converting enzyme	Homo sapiens	26-37
6165739-5	1981	We conclude that the endogenous kallikrein-kinin system represents a significant modulator of vasopressin action and it permits separate control of vasopressin-stimulated water flow and solute transport.	Water	171-176	arginine vasopressin	Homo sapiens	148-159
6787081-7	1981	We conclude that the major effect of VIP in the human jejunum is to decrease the normal absorption of water and electrolytes--not only active bicarbonate-mediated absorption, but also the passive absorption in response to osmotic forces generated by active or facilitated absorptive processes.	Water	102-107	vasoactive intestinal peptide	Homo sapiens	37-40
7251948-3	1981	Plasma PGE2 may act as both a tonic inhibitor of drinking and a satiety indicator in situations in which water intake is stimulated by increases in blood levels of angiotensin II.	Water	105-110	angiotensinogen	Rattus norvegicus	164-178
6267350-0	1981	Vasopressin-prostaglandin interactions in the regulation of epithelial cell permeability to water.	Water	92-97	arginine vasopressin	Homo sapiens	0-11
7018256-4	1981	At least three physiologic effects have been clearly documented: reduction of vasopressin-dependent osmotic water permeability of the collecting tubule epithelium, enhancement of medullary blood flow, and inhibition of NaCl absorption from the thick ascending limb of Henle"s loop.	Water	108-113	arginine vasopressin	Homo sapiens	78-89
7248274-2	1981	The peptide amide hydrogen exchange rate of human angiotensin II in H2O have been measured at room temperature by the transfer of solvent saturation method.	Water	68-71	angiotensinogen	Homo sapiens	50-64
7289399-5	1981	Addition of vasopressin to the bath caused the transtubular osmotic water permeability coefficient to increase to values of 125, 175, and 155 X 10(-4) cm/sec in three tubules thus studied.	Water	68-73	arginine vasopressin	Homo sapiens	12-23
7223313-3	1981	The water deprivation significantly increased plasma immunoreactive AII concentration (P less than 0.002) together with plasma osmolality and sodium concentration, and reduced the potassium concentration.	Water	4-9	angiotensinogen	Rattus norvegicus	68-71
6266956-3	1981	In the rats drinking tap water, systolic pressure gradually increased over a period of several weeks and then was sustained in a dose-related manner for the duration of the treatment.	Water	25-30	nuclear RNA export factor 1	Rattus norvegicus	21-24
7018773-3	1981	In normal subjects, plasma ADH rose progressively till the end of the study (1.5 pg/ml per hour corresponding to about 3 pg/ml per liter of plasma water lost) whereas it remained unchanged in hypertensive patients.	Water	147-152	arginine vasopressin	Homo sapiens	27-30
6265463-1	1981	Vasopressin increases the water permeability of the luminal membrane of the toad bladder epithelial cell.	Water	26-31	arginine vasopressin	Homo sapiens	0-11
6265463-3	1981	Withdrawal of vasopressin is ordinarily associated with a rapid reduction of water flow to baseline values and a simultaneous disappearance of the particle aggregates.	Water	77-82	arginine vasopressin	Homo sapiens	14-25
6265463-4	1981	The bifunctional imidoesters dithiobispropionimidate (DTBP) and dimethylsuberimidate (DMS), which cross-link amino groups in membrane proteins and lipids, slow the return of water flow to baseline after vasopressin withdrawal.	Water	174-179	arginine vasopressin	Homo sapiens	203-214
7209515-1	1981	Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats.	Water	150-155	arginine vasopressin	Rattus norvegicus	30-41
7236625-2	1981	The binding constants of the first and second water molecules were determined to be 209 +/- 3 M-1 and 22 +/- 1 M-1, respectively.	Water	46-51	myoregulin	Homo sapiens	94-114
7209515-1	1981	Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats.	Water	150-155	arginine vasopressin	Rattus norvegicus	121-132
7472279-1	1981	The purpose of these experiments was to determine if angiotensin II mediates the stimulation of water transport in the rat distal colon via an electroneutral mechanism.	Water	96-101	angiotensinogen	Rattus norvegicus	53-67
7472279-12	1981	These data suggest that angiotensin II can stimulate and inhibit intestinal water transport via electroneutral mechanisms.	Water	76-81	angiotensinogen	Rattus norvegicus	24-38
7225020-2	1981	Cold-acclimated rats, administered the dipsogenic agents angiotensin I, angiotensin II, isoproterenol or serotonin, had water intakes not significantly different from control rats.	Water	120-125	angiotensinogen	Rattus norvegicus	72-86
7212090-1	1981	Normal rats (N) and rats with hereditary hypothalamic diabetes insipidus (DI) were employed to examine the role of arginine vasopressin (AVP) in the reduction of water intake and urine output during hypoxic exposure.	Water	162-167	arginine vasopressin	Rattus norvegicus	115-135
7212090-1	1981	Normal rats (N) and rats with hereditary hypothalamic diabetes insipidus (DI) were employed to examine the role of arginine vasopressin (AVP) in the reduction of water intake and urine output during hypoxic exposure.	Water	162-167	arginine vasopressin	Rattus norvegicus	137-140
7212095-1	1981	The systemic administration of angiotensin II or its precursors will result in increased water intake.	Water	89-94	angiotensinogen	Homo sapiens	31-45
7204574-2	1981	At low physiological doses, angiotensin II (AII) stimulates jejunal sodium and water absorption, while at high doses peptide inhibits absorption and/or stimulates secretion.	Water	79-84	angiotensinogen	Rattus norvegicus	28-42
7204574-2	1981	At low physiological doses, angiotensin II (AII) stimulates jejunal sodium and water absorption, while at high doses peptide inhibits absorption and/or stimulates secretion.	Water	79-84	angiotensinogen	Rattus norvegicus	44-47
7204574-6	1981	The increased water transport in response to (Sar1 Leu8)-AII is not secondary to enhanced renal renin release, as the analog also stimulated jejunal transport in the presence of captopril and after bilateral nephrectomy.	Water	14-19	angiotensinogen	Rattus norvegicus	57-60
7212095-3	1981	Although there are without question multiple mediators of thirst associated with extracellular thirst challenges, one of the major factors responsible for water intake has been hypothesized to be the action of angiotensin II.	Water	155-160	angiotensinogen	Homo sapiens	210-224
6163955-0	1981	Does substance P participate in water transport and excretion?	Water	32-37	tachykinin precursor 1	Homo sapiens	5-16
6265294-4	1981	Following secretion or VIP the changes in pancreatic tissue cyclic AMP concentrations precede the physiological response, i.e. enhance water and electrolyte secretion.	Water	135-140	vasoactive intestinal peptide	Homo sapiens	23-26
7225466-8	1981	The interaction between lipase and colipase is enhanced when the complex is adsorbed at the lipid-water interface.	Water	98-103	pancreatic lipase	Equus caballus	24-30
6163955-2	1981	There is theoretical and experimental evidence that substance P may regulate water excretion by at least two different mechanisms.	Water	77-82	tachykinin precursor 1	Homo sapiens	52-63
6111357-4	1981	Reduced insulin and DOI lose their ordered structure in water, but their helical conformation is restored in surfactant solutions.	Water	56-61	insulin	Homo sapiens	8-15
7242389-1	1981	A microorganism oxidizing As(III) to As(V) was isolated from the water of a gold-arsenic deposit; the process occurs under the autotrophic conditions.	Water	65-70	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-42
7468100-3	1981	Endogenous vasopressin activity was demonstrated after prolonged water deprivation.	Water	65-70	arginine vasopressin	Homo sapiens	11-22
7468100-8	1981	Plasma vasopressin was suppressed with water loading but remained suppressed 90 min after tilt table testing.	Water	39-44	arginine vasopressin	Homo sapiens	7-18
7255554-0	1981	The involvement of water at the retinal binding site in rhodopsin and early light-induced intramolecular proton transfer.	Water	19-24	rhodopsin	Homo sapiens	56-65
7006848-10	1981	These studies clearly demonstrate that circulating AVP contributes to the maintenance of AP during water deprivation in the anesthetized rat.	Water	99-104	arginine vasopressin	Rattus norvegicus	51-54
6257881-3	1981	Amrinone enhanced the effect of vasopressin and cyclic AMP on water and urea permeabilities, as well as the effect of vasopressin on sodium transport.	Water	62-67	arginine vasopressin	Homo sapiens	32-43
6163855-0	1981	The effects of antidiuretic hormone (ADH) on solute and water transport in the mammalian nephron.	Water	56-61	arginine vasopressin	Homo sapiens	15-35
6163855-0	1981	The effects of antidiuretic hormone (ADH) on solute and water transport in the mammalian nephron.	Water	56-61	arginine vasopressin	Homo sapiens	37-40
7215432-3	1981	Naloxone also produced a dose-related suppression of water consumption induced by isoproterenol and angiotensin II, agents simulating conditions of extracellular dehydration.	Water	53-58	angiotensinogen	Rattus norvegicus	100-114
7192710-2	1981	Lysozyme solubilized in reverse micelles of bis(2-ethylhexyl) sodium sulfosuccinate in isooctane containing as little as 0.8% water (v/v) has been shown to be active.	Water	126-131	lysozyme	Homo sapiens	0-8
7192710-4	1981	The dependence of lysozyme activity on pH in reverse micelles is different than that in water, with the entire pH profile shifted 2 to 3 pH units higher in reverse micelles.	Water	88-93	lysozyme	Homo sapiens	18-26
7192710-7	1981	Spectroscopic studies (CD, fluorescence, and UV absorbance) indicate that the conformation of lysozyme is significantly different in reverse micelles compared to water.	Water	162-167	lysozyme	Homo sapiens	94-102
7192710-8	1981	In particular, CD studies indicate that the helical content of lysozyme changes from approximately 34% in water to approximately 48% in reverse micelles.	Water	106-111	lysozyme	Homo sapiens	63-71
6259206-1	1981	Role of calmodulin vasopressin-stimulation of water permeability.	Water	46-51	calmodulin 1	Homo sapiens	8-18
6259206-1	1981	Role of calmodulin vasopressin-stimulation of water permeability.	Water	46-51	arginine vasopressin	Homo sapiens	19-30
6259206-4	1981	10 microM trifluoperazine inhibited vasopressin stimulation of water flow, but did not alter vasopressin"s effects on urea permeability or short-circuit current.	Water	63-68	arginine vasopressin	Homo sapiens	36-47
7457608-1	1981	At low doses, angiotensin II (AII) stimulates jejunal sodium and water absorption in the pentobarbital sodium-anesthetized rat.	Water	65-70	angiotensinogen	Rattus norvegicus	14-28
7217254-2	1981	Reversed-phase chromatography on short-chain alkylsilica (C2) or octadecylsilica (C18) with acetonitrile--dimethylsulphoxide--water as eluent is used for the separation of bilirubin.	Water	126-131	Bardet-Biedl syndrome 9	Homo sapiens	82-85
7348020-5	1981	At the same time, AII significantly increased the rate of sodium intake and the sodium appetite when a choice of water and NaCl was offered, and the basis of comparison was the water depleted group.	Water	113-118	angiotensinogen	Rattus norvegicus	18-21
7348020-6	1981	When water was changed for 5% glucose, the animals receiving AII showed no significant sodium appetite, and drank so much glucose solution that their blood glucose increased to 202 +/- 26 mg/dl, and glucose appeared in their urine.	Water	5-10	angiotensinogen	Rattus norvegicus	61-64
7269990-4	1981	After extraction of the hormone from plasma and cerebrospinal fluid the vasopressin concentration was determined by means of the antidiuretic bioassay in the water-loaded rat.	Water	158-163	arginine vasopressin	Rattus norvegicus	72-83
6779639-1	1981	Membrane fluidity, urea permeability, and osmotic water permeability in toad urinary bladder are regularly enhanced by antidiuretic hormone (ADH).	Water	50-55	arginine vasopressin	Homo sapiens	119-139
6779639-1	1981	Membrane fluidity, urea permeability, and osmotic water permeability in toad urinary bladder are regularly enhanced by antidiuretic hormone (ADH).	Water	50-55	arginine vasopressin	Homo sapiens	141-144
6779639-2	1981	In addition, organized intramembranous particle aggregates, which correlate specifically with hormonally stimulated water permeability, are found in granular cell luminal membranes consequent to ADH stimulation.	Water	116-121	arginine vasopressin	Homo sapiens	195-198
6779639-3	1981	In this investigation ADH-stimulated changes in urea and osmotic water permeability and luminal membrane aggregates at room temperature (24.8 +/- 0.4 degrees C) and in the cold 10.6 +/- 0.2 degrees) were compared with corresponding changes in membrane fluidity, as assessed by n-butyramide permeability.	Water	65-70	arginine vasopressin	Homo sapiens	22-25
6779639-5	1981	ADH-stimulated osmotic water permeability in toad bladder is also independent of the coincident change in membrane fluidity, and as a process almost certainly involves membrane channels, not a solubility-diffusion process through membrane lipids.	Water	23-28	arginine vasopressin	Homo sapiens	0-3
7457608-4	1981	The AII-induced inhibition of water absorption can be abolished, and a net stimulation ensues after pretreatment of the animals with meclofenamate or indomethacin, suggesting that at high doses AII stimulates intestinal prostaglandin biosynthesis.	Water	30-35	angiotensinogen	Rattus norvegicus	4-7
7457608-5	1981	The AII analogue, [Sar1,Leu8]AII, significantly stimulated jejunal water absorption and was devoid of any inhibitory response at any dose administered.	Water	67-72	angiotensinogen	Rattus norvegicus	4-7
7457608-1	1981	At low doses, angiotensin II (AII) stimulates jejunal sodium and water absorption in the pentobarbital sodium-anesthetized rat.	Water	65-70	angiotensinogen	Rattus norvegicus	30-33
7457608-5	1981	The AII analogue, [Sar1,Leu8]AII, significantly stimulated jejunal water absorption and was devoid of any inhibitory response at any dose administered.	Water	67-72	angiotensinogen	Rattus norvegicus	29-32
7457608-6	1981	Simultaneous infusion of low doses of [Sar1,Leu8]AII and AII resulted in a stimulation of water transport, while simultaneous infusion of high dose [Sar1,Leu8]AII and AII also stimulated water absorption.	Water	90-95	angiotensinogen	Rattus norvegicus	49-52
7002346-7	1981	It also was demonstrated that fetal hypoxemia produced a significant increase in fetal plasma concentrations of vasopressin associated with an antidiuresis in all but one near-term fetus and in 50% of the young fetuses, suggesting that the ability of the fetal kidney to reabsorb free water is more developed in near-term fetuses.	Water	285-290	arginine vasopressin	Homo sapiens	112-123
7457608-6	1981	Simultaneous infusion of low doses of [Sar1,Leu8]AII and AII resulted in a stimulation of water transport, while simultaneous infusion of high dose [Sar1,Leu8]AII and AII also stimulated water absorption.	Water	90-95	angiotensinogen	Rattus norvegicus	57-60
7457608-6	1981	Simultaneous infusion of low doses of [Sar1,Leu8]AII and AII resulted in a stimulation of water transport, while simultaneous infusion of high dose [Sar1,Leu8]AII and AII also stimulated water absorption.	Water	90-95	angiotensinogen	Rattus norvegicus	57-60
7457608-6	1981	Simultaneous infusion of low doses of [Sar1,Leu8]AII and AII resulted in a stimulation of water transport, while simultaneous infusion of high dose [Sar1,Leu8]AII and AII also stimulated water absorption.	Water	90-95	angiotensinogen	Rattus norvegicus	57-60
7457608-6	1981	Simultaneous infusion of low doses of [Sar1,Leu8]AII and AII resulted in a stimulation of water transport, while simultaneous infusion of high dose [Sar1,Leu8]AII and AII also stimulated water absorption.	Water	187-192	angiotensinogen	Rattus norvegicus	49-52
7457608-6	1981	Simultaneous infusion of low doses of [Sar1,Leu8]AII and AII resulted in a stimulation of water transport, while simultaneous infusion of high dose [Sar1,Leu8]AII and AII also stimulated water absorption.	Water	187-192	angiotensinogen	Rattus norvegicus	57-60
7457608-6	1981	Simultaneous infusion of low doses of [Sar1,Leu8]AII and AII resulted in a stimulation of water transport, while simultaneous infusion of high dose [Sar1,Leu8]AII and AII also stimulated water absorption.	Water	187-192	angiotensinogen	Rattus norvegicus	57-60
7457608-6	1981	Simultaneous infusion of low doses of [Sar1,Leu8]AII and AII resulted in a stimulation of water transport, while simultaneous infusion of high dose [Sar1,Leu8]AII and AII also stimulated water absorption.	Water	187-192	angiotensinogen	Rattus norvegicus	57-60
7457630-0	1981	Water intake elicited by injections of angiotensin II into preoptic area of rats.	Water	0-5	angiotensinogen	Rattus norvegicus	39-53
7317155-1	1981	To work out methods of synthesis of stabilized enzymatic preparations for clinical application, subunit enzyme glyceraldehyde-3-phosphatedehydrogenase was treated with bifunctional reagents--aliphatic diacids, activated by water-soluble carbodiimide.	Water	223-228	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	111-150
7215069-5	1981	On the second to third day after substitution of saline for drinking water, urinary vasopressin excretion (UADHV) was increased six-fold and the plasma vasopressin concentration was increased two and one-half-fold.	Water	69-74	arginine vasopressin	Rattus norvegicus	84-95
7215069-5	1981	On the second to third day after substitution of saline for drinking water, urinary vasopressin excretion (UADHV) was increased six-fold and the plasma vasopressin concentration was increased two and one-half-fold.	Water	69-74	arginine vasopressin	Rattus norvegicus	152-163
7009285-1	1981	Insulin is insoluble in water at physiological pH, but dissolves relatively rapidly in plasma.	Water	24-29	insulin	Homo sapiens	0-7
7230039-30	1981	This and other recent studies demonstrate the wide phylogenetic distribution of the dipsogenic action of angiotensin II and support the idea that the control of water intake is an important physiological function of the renin-angiotensin system in vertebrates.	Water	161-166	renin	Columba livia	220-225
6792357-2	1981	In the toad urinary bladder, the hormone vasopressin increases the osmotic water permeability of the granular epithelial cell"s luminal membrane, and also leads to the appearance of aggregates of particles within this membrane.	Water	75-80	arginine vasopressin	Homo sapiens	41-52
6280546-0	1981	Evidence for calmodulin dependence of water permeability in toad urinary bladder.	Water	38-43	calmodulin 1	Homo sapiens	13-23
6164784-4	1981	Mammalian renin injected into the brain caused the water-replete pigeon to drink but it was a less effective dipsogen than in the mammal.	Water	51-56	renin	Homo sapiens	10-15
7230042-5	1981	The water intake of male rats subjected to 48 hr water deprivation was substantially increased after injection of prolactin.	Water	4-9	prolactin	Rattus norvegicus	114-123
7230042-5	1981	The water intake of male rats subjected to 48 hr water deprivation was substantially increased after injection of prolactin.	Water	49-54	prolactin	Rattus norvegicus	114-123
6268776-10	1981	The restructuring of the apical membrane underlying the transition from a low to a higher state of water permeability is very likely related to the appearance of intramembrane particle aggregates detectable with the freeze-fracture technique in epithelia exposed to vasopressin.	Water	99-104	arginine vasopressin	Homo sapiens	266-277
7230042-15	1981	It is concluded that prolactin may act to increase the net water gain of animals suffering a deficit of the extracellular fluid space but is without effect on stimuli arising from deficits in the intracellular fluid space.	Water	59-64	prolactin	Rattus norvegicus	21-30
7012496-5	1981	In some cases PRA and A II were elevated; this however was probably due to increased renin secretion following changes in water and electrolyte balance rather than to decreased hepatic metabolism of renin.	Water	122-127	renin	Homo sapiens	85-90
6271963-0	1981	Water soluble receptors for human growth hormone from rabbit liver.	Water	0-5	growth hormone 1	Homo sapiens	34-48
7265302-5	1981	Addition of hormones to the culture medium stimulated the rate of appearance of water-soluble metabolites, AAF, correlating with the enhanced cytochrome P-450 levels of hormone-treated cells.	Water	80-85	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	142-158
7446731-1	1980	Vasopressin increases the permeability of collecting ducts to water.	Water	62-67	arginine vasopressin	Rattus norvegicus	0-11
7029856-1	1981	Previous studies have demonstrated that after intravesical inoculation of Escherichia coli, rats drinking 5% glucose-water remained bacteriuric for up to 21 days while rats drinking tap water became abacteriuric within a few days.	Water	186-191	nuclear RNA export factor 1	Rattus norvegicus	182-185
7029856-4	1981	Of rats drinking tap water, 6 of 7 (85%) with intrapelvic bladders and 8 of 9 (89%) with ventral hernias had less than 10 colony forming units per ml of urine within 9 days of inoculation.	Water	21-26	nuclear RNA export factor 1	Rattus norvegicus	17-20
7446731-8	1980	Accordingly, quantitation of CDLM clusters may serve as an end point for the study of vasopressin-induced water permeability.	Water	106-111	arginine vasopressin	Rattus norvegicus	86-97
7428699-0	1980	Stimulation of intestinal sodium and water transport in vivo by angiotensin II and analogs.	Water	37-42	angiotensinogen	Homo sapiens	64-78
6256110-10	1980	Unlike the normotensive rats, which did not show a relationship between beta-adrenoreceptor number and blood pressure, spontaneously hypertensive rats on tap water and 1% NaCl showed a significant negative logarithmic relationship between these two variables.	Water	158-163	nuclear RNA export factor 1	Rattus norvegicus	154-157
7435649-1	1980	A small discrete area near the optic recess of the anterior ventral third ventricle (AV3V) in the rat brain has been shown to be an important mediator of cardiovascular and dipsogenic response to angiotensin II and osmotic stimuli and to be involved in normal day-to-day regulation of water and electrolyte balance.	Water	285-290	angiotensinogen	Rattus norvegicus	196-210
6777397-8	1980	Arachidonic acid, the specific precursor of prostaglandin synthesis, increased PGE2 synthesis twofold, and significantly inhibited AVP- and DDAVP-stimulated water flow by 60 and 75%, respectively.	Water	157-162	arginine vasopressin	Homo sapiens	131-134
6777397-9	1980	Naproxen and acetaminophen inhibited prostaglandin synthesis and enhanced water flow in response to AVP and DDAVP (44-54%).	Water	74-79	arginine vasopressin	Homo sapiens	100-103
6777397-11	1980	Because agents such as acetaminophen and naproxen inhibit prostaglandin synthesis and enhance vasopressin- and DDAVP-stimulated water flow, we suggest that it is the inhibitory effect of these agents on the hormone-independent rate of prostaglandin synthesis that is responsible for their enhancement of water flow.	Water	128-133	arginine vasopressin	Homo sapiens	94-105
6777398-3	1980	U44069 (1 muM) stimulated water flow from 3.6+/-0.8 to 12.4+/-1.2 mg/min per 10 cm(2) hemibladder surface area, while U46619 (1 muM) stimulated water flow from 2.8+/-1.0 to 21.8+/-2.0 mg/min per 10 cm(2).	Water	26-31	latexin	Homo sapiens	10-13
6777398-4	1980	The prostaglandin endoperoxide/thromboxane A(2) antagonist trans- 13-azaprostanoic acid, an inhibitor of vasopressin-stimulated water flow, inhibited thromboxane B(2)- and U46619-stimulated water flow in a dose-dependent manner.	Water	128-133	arginine vasopressin	Homo sapiens	105-116
7208547-6	1980	The antagonistic action of PGE1 on water-deprivation, or AII-induced water intake, and the enhancement of water intake after blocking PGs synthesis, suggests the involvement of PG in the regulation of thirst.	Water	69-74	angiotensinogen	Rattus norvegicus	57-60
7449837-1	1980	Water deprivation, drinking water containing 2% NaCl, or systemic injection with histamine or nicotine markedly increased plasma levels of vasopressin in rats.	Water	28-33	arginine vasopressin	Rattus norvegicus	139-150
7001928-9	1980	Plasma renin activity was significantly elevated by water deprivation, while after rehydration this activity had decreased to levels not significantly different from predeprivation values.	Water	52-57	renin	Homo sapiens	7-12
6777398-4	1980	The prostaglandin endoperoxide/thromboxane A(2) antagonist trans- 13-azaprostanoic acid, an inhibitor of vasopressin-stimulated water flow, inhibited thromboxane B(2)- and U46619-stimulated water flow in a dose-dependent manner.	Water	190-195	arginine vasopressin	Homo sapiens	105-116
6777398-6	1980	U46619 (1 muM) enhanced vasopressin-stimulated water flow in indomethacin pretreated hemibladders, producing a significant parallel shift (P < 0.001) in the dose-response relationship to submaximal concentrations of vasopressin (0.1-0.6 mU/ml), while not affecting water flow stimulated by supramaximal concentrations of vasopressin (10 mU/ml).	Water	47-52	latexin	Homo sapiens	10-13
6777398-6	1980	U46619 (1 muM) enhanced vasopressin-stimulated water flow in indomethacin pretreated hemibladders, producing a significant parallel shift (P < 0.001) in the dose-response relationship to submaximal concentrations of vasopressin (0.1-0.6 mU/ml), while not affecting water flow stimulated by supramaximal concentrations of vasopressin (10 mU/ml).	Water	47-52	arginine vasopressin	Homo sapiens	24-35
6777398-7	1980	trans-13-Azaprostanoic acid abolished the potentiating effects of U46619 on vasopressin-stimulated water flow.	Water	99-104	arginine vasopressin	Homo sapiens	76-87
7208547-6	1980	The antagonistic action of PGE1 on water-deprivation, or AII-induced water intake, and the enhancement of water intake after blocking PGs synthesis, suggests the involvement of PG in the regulation of thirst.	Water	69-74	angiotensinogen	Rattus norvegicus	57-60
6252784-1	1980	Vasopressin stimulates osmotic water flow and urea permeability in the toad urinary bladder via separate cAMP-responsive mechanisms.	Water	31-36	arginine vasopressin	Homo sapiens	0-11
7462184-7	1980	The remaining lipid core of LDL was not destroyed by detergent at 25 degrees C, but it was at 35 degrees C. The Tween 80-extracted apo B was purified by gel chromatography and its molecular weight and partial specific volume were determined by sedimentation equilibrium analysis in H2O and D2O buffers.	Water	282-285	apolipoprotein B	Homo sapiens	131-136
6257605-0	1980	Effect of parathyroid hormone on jejunal electrolyte and water transport and cyclic nucleotide formation in the rat.	Water	57-62	parathyroid hormone	Rattus norvegicus	10-29
6252784-2	1980	Hydrazine (10--20 MM), added to the bladder"s serosal bath, reversibly enhanced the effect of both low and saturating levels of vasopressin on osmotic water flow, without increasing urea permeability.	Water	151-156	arginine vasopressin	Homo sapiens	128-139
6251910-1	1980	A common step in vasopressin- and hypertonicity-induced water flow.	Water	56-61	arginine vasopressin	Homo sapiens	17-28
6903427-8	1980	In the rat vasopressin-induced changes in kallikrein excretion were positively correlated with changes in sodium and potassium excretion and negatively correlated with changes in free water clearance.	Water	184-189	arginine vasopressin	Rattus norvegicus	11-22
6252784-8	1980	Further strengthening the relationship between kinase activation and water flow, we found that methohexital, an inhibitor of vasopressin-stimulated water flow and adenylate cyclase, also decreased the kinase activity ratio in the presence of vasopressin.	Water	69-74	arginine vasopressin	Homo sapiens	125-136
6252784-8	1980	Further strengthening the relationship between kinase activation and water flow, we found that methohexital, an inhibitor of vasopressin-stimulated water flow and adenylate cyclase, also decreased the kinase activity ratio in the presence of vasopressin.	Water	148-153	arginine vasopressin	Homo sapiens	125-136
6252784-8	1980	Further strengthening the relationship between kinase activation and water flow, we found that methohexital, an inhibitor of vasopressin-stimulated water flow and adenylate cyclase, also decreased the kinase activity ratio in the presence of vasopressin.	Water	148-153	arginine vasopressin	Homo sapiens	242-253
6263359-4	1980	The electron transport from water to NADP+ or ferricyanide in the mutants was completely blocked; however, it was partly restored by an addition of exogenous cytochrome c553 to the cell fragments.	Water	28-33	cytochrome c, somatic	Homo sapiens	158-170
6252784-9	1980	These studies link closely the role of cAMP-dependent kinase and luminal membrane aggregates to the specific mediation of vasopressin-stimulated water flow in the bladder.	Water	145-150	arginine vasopressin	Homo sapiens	122-133
7000955-1	1980	Rats given free access to food, water and 2.7% NaCl and injected with either renin or angiotensin II into the preoptic area showed an immediate increase in water intake followed by an increase in intake of 2.7% NaCl.	Water	156-161	angiotensinogen	Rattus norvegicus	86-100
6165574-1	1980	Intraventricular administration of tonin, an enzyme which forms angiotensin II directly from a natural protein substrate (angiotensinogen), stimulated water drinking and increased systemic blood pressure in rats.	Water	151-156	angiotensinogen	Rattus norvegicus	122-137
6165574-4	1980	These results indicate that the central effects of tonin on water drinking and systemic blood pressure are mediated via the direct formation of angiotensin II in the brain, and suggest the possibility that the tonin-angiotensin II system in the central nervous system might be important in controlling water balance and blood pressure.	Water	60-65	angiotensinogen	Rattus norvegicus	144-158
6165574-4	1980	These results indicate that the central effects of tonin on water drinking and systemic blood pressure are mediated via the direct formation of angiotensin II in the brain, and suggest the possibility that the tonin-angiotensin II system in the central nervous system might be important in controlling water balance and blood pressure.	Water	60-65	angiotensinogen	Rattus norvegicus	216-230
7470101-1	1980	The interaction of human serum albumin with monomeric haemin has been investigated by detailed kinetic analysis in dimethyl sulphoxide/water (3:5, v/v).	Water	135-140	albumin	Homo sapiens	25-38
7214720-4	1980	When the patient was deprived of water, diastolic pressure increased, despite the fluid loss, from 90 to 105 mmHg, with a comparable increase of plasma AVP concentration of 15.3 fmol/ml.	Water	33-38	arginine vasopressin	Homo sapiens	152-155
7191763-1	1980	During the rat oestrous cycle, cholinergic-stimulated water intake is constant across days; while both daily ad lib and angiotensin II-stimulated water intakes are least on the day of oestrus.	Water	146-151	angiotensinogen	Rattus norvegicus	120-134
6776308-3	1980	The body cell mass represented by the exchangeable potassium to total body water ratio correlated significantly (p < 0.001) with the serum albumin concentration (r = 0.59) and significantly (p < 0.001) to total protein (r = 0.59).	Water	75-80	albumin	Homo sapiens	136-149
7002532-1	1980	In healthy male subjects the hyperthermic water bath (40 degrees C for 30 min) induced an increase of growth hormone (GH) level in plasma with the increment higher than 5 ng ml-1.	Water	42-47	growth hormone 1	Homo sapiens	102-116
6253842-2	1980	The effects were studied of vasoactive intestinal polypeptide (VIP), theophylline, and morphine on net water flux and cyclic adenosine 3",5"-monophosphate (cyclic AMP) levels in the jejunum of anaesthetized rats in vivo and of VIP and morphine on adenylate cyclase activity in rat epithelial cell membranes in vitro.	Water	103-108	vasoactive intestinal peptide	Rattus norvegicus	63-66
6253842-4	1980	Infusion of VIP (0.1-2 x 10(-9) mol/min/kg) dose dependently caused a reversal from net water absorption to net secretion; 2 x 10(-9) mol/min/kg enhanced the mucosal cyclic AMP content by 67%.	Water	88-93	vasoactive intestinal peptide	Rattus norvegicus	12-15
7429339-4	1980	In the anaesthetised dogs, transient distention of the acute fundic pouch with 0.15 M hydrochloric acid under a pressure of 40 cm of water elicited a significant rise of portal VIP from 36.2 +/- 8.9 to 59.8 +/- 12.4 pg ml-1 (P < 0.05) without any significant variation of the peptide concentration in peripheral plasma.	Water	133-138	vasoactive intestinal peptide	Canis lupus familiaris	177-180
7460359-0	1980	[Effect of synthetic arginine vasopressin on the urinary excretion of water and electrolytes in man (author"s transl)].	Water	70-75	arginine vasopressin	Homo sapiens	30-41
7413018-1	1980	Angiotensin II (AII) was infused into the lateral cerebral ventricle of rats given water, isotonic saline, or hypertonic saline ad libitum, or 40 ml water/day.	Water	83-88	angiotensinogen	Rattus norvegicus	0-20
7413018-1	1980	Angiotensin II (AII) was infused into the lateral cerebral ventricle of rats given water, isotonic saline, or hypertonic saline ad libitum, or 40 ml water/day.	Water	149-154	angiotensinogen	Rattus norvegicus	0-20
7413018-5	1980	AII infusions in rat given water or isotonic saline to drink decreased plasma [Na+] with no changes in plasma or pituitary AVP.	Water	27-32	angiotensinogen	Rattus norvegicus	0-3
7413018-7	1980	In water-restricted rats, the effects of AII were intermediate: a small decrease in plasma [Na+] and a small increase in plasma AVP.	Water	3-8	angiotensinogen	Rattus norvegicus	41-44
6253842-6	1980	Theophylline (5 mg/ml, intraluminally) enhanced the effect of intra-arterial infusion of VIP (2 x 10(-9) mol/min/kg) as to net water secretion and increase in mucosal cyclic AMP content.	Water	127-132	vasoactive intestinal peptide	Rattus norvegicus	89-92
6253842-14	1980	The finding that low doses of VIP, which already have an effect on net water flux, fail to increase cyclic AMP levels makes it likely that other mediators besides cyclic AMP are involved in the effect of VIP on net water flux.	Water	215-220	vasoactive intestinal peptide	Rattus norvegicus	204-207
6773423-2	1980	Carbachol caused a small increase in base-line water flow and inhibited, partially, vasopressin- (AVP) or cyclic AMP-stimulated water flow.	Water	128-133	arginine vasopressin	Homo sapiens	84-95
6773546-0	1980	Properties of human apolipoprotein A-I at the air-water interface.	Water	50-55	apolipoprotein A1	Homo sapiens	20-38
6773424-0	1980	Vasopressin-stimulated water flow is decreased by thromboxane synthesis inhibition or antagonism.	Water	23-28	arginine vasopressin	Homo sapiens	0-11
6773424-1	1980	The time course of vasopressin stimulation of water flow and immunoreactive thromboxane B2 (iTXB2) and prostaglandin E (iPGE) biosynthesis was studied in the isolated toad urinary bladder.	Water	46-51	arginine vasopressin	Homo sapiens	19-30
6773424-4	1980	Maximum vasopressin-stimulated water flow was reached between 16 and 24 min.	Water	31-36	arginine vasopressin	Homo sapiens	8-19
6773424-5	1980	7-(1-Imidazolyl)-heptanoic acid (7IHA), a thromboxane synthetase inhibitor, inhibited both vasopressin-stimulated water flow and iTXB2 synthesis in a dose-dependent fashion, but did not affect iPGE synthesis.	Water	114-119	arginine vasopressin	Homo sapiens	91-102
6773424-6	1980	Vasopressin-stimulated water flow and iTXB2 synthesis were significantly correlated (r = 0.75, n = 24, P less than 0.001).	Water	23-28	arginine vasopressin	Homo sapiens	0-11
6773424-7	1980	13-Azaprostanoic acid (13APA), a thromboxane antagonist, inhibited vasopressin-stimulated water flow in a dose-dependent fashion.	Water	90-95	arginine vasopressin	Homo sapiens	67-78
6773424-8	1980	Inhibition of arachidonic acid metabolism abolished the effects of 7IHA and 13APA on vasopressin-stimulated water flow.	Water	108-113	arginine vasopressin	Homo sapiens	85-96
6773424-10	1980	These results confirm that vasopressin stimulates TXA2 and PGE synthesis and support the hypothesis that TXA2 is a positive modulator of vasopressin-stimulated water flow in the toad urinary bladder.	Water	160-165	arginine vasopressin	Homo sapiens	27-38
6773424-10	1980	These results confirm that vasopressin stimulates TXA2 and PGE synthesis and support the hypothesis that TXA2 is a positive modulator of vasopressin-stimulated water flow in the toad urinary bladder.	Water	160-165	arginine vasopressin	Homo sapiens	137-148
6252744-1	1980	To investigate the effect of a met-enkephalin analogue, FK 33-824, on renal handling of water, 8 subjects were given 0.5 mg im of the drug or placebo in a cross-over study.	Water	88-93	proopiomelanocortin	Homo sapiens	31-45
6107910-0	1980	Somatostatin: an endogenous peptide in the toad urinary bladder inhibits vasopressin-stimulated water flow.	Water	96-101	arginine vasopressin	Homo sapiens	73-84
6107910-4	1980	Somatostatin produced a dose-dependent, reversible inhibition of vasopressin-stimulated osmotic water flow; it inhibited theophylline-stimulated osmotic water flow but not the water flow stimulated by 8-p-chlorophenylthioadenosine 3",5"-cyclic monophosphate.	Water	96-101	arginine vasopressin	Homo sapiens	65-76
6107910-8	1980	We propose that endogenous somatostatin may function as a local regulator of the cellular action of vasopressin on osmotic water flow.	Water	123-128	arginine vasopressin	Homo sapiens	100-111
7009025-3	1980	Since studies have demonstrated that in normal man the central hypervolaemia induced by water immersion to the neck produces a prompt and profound suppression of plasma renin activity and plasma aldosterone concentration without concomitant alteration of plasma composition, immersion afforded a unique opportunity to assess simultaneously the effects of central hypervolaemia on plasma renin activity, plasma aldosterone concentration and prostaglandin E excretion.	Water	88-93	renin	Homo sapiens	169-174
7430888-0	1980	Stimulatory action of angiotensin II on water and electrolyte transport by the proximal colon of the rat.	Water	40-45	angiotensinogen	Rattus norvegicus	22-36
6249984-0	1980	The effect of acid-base changes on vasopressin-stimulated water flow in toad urinary bladder.	Water	58-63	arginine vasopressin	Homo sapiens	35-46
7004802-3	1980	Aldosteronism was strongly correlated to increased activity of the renin-angiotensin-system, both anteceded by restriction of the extracellular space and expansion of total body water.	Water	178-183	renin	Homo sapiens	67-72
6102948-1	1980	We determined the effect of somatostatin on water, glucose, sodium, and urea transport by utilizing an in vivo perfusion technique in the rat jejunum.	Water	44-49	somatostatin	Rattus norvegicus	28-40
6102948-8	1980	These results demonstrate that somatostatin may affect water and electrolyte movement by blocking the action of cyclic AMP in the rat jejunum.	Water	55-60	somatostatin	Rattus norvegicus	31-43
6103008-5	1980	Both oxilorphan and butorphanol significantly elevated the plasma osmolality at which ADH release became evident after the infusion of hypertonic saline in water-loaded subjects.	Water	156-161	arginine vasopressin	Homo sapiens	86-89
6251919-1	1980	It has been shown that during fast (< 1 ms) photosensitized by anthraquinone or benzophenone reduction of cytochrome c in 0.15 N NaOH water-glycerol solutions ferrocytochrome c in a nonequilibrium state with increased reactivity was formed.	Water	137-142	cytochrome c, somatic	Homo sapiens	109-121
6249735-5	1980	In sodium-depleted rats, water intake was lower than in controls after AII given i.v.t.	Water	25-30	angiotensinogen	Rattus norvegicus	71-74
7218660-4	1980	Following the acute water load, plasma vasopressin levels, as measured by radioimmunoassay, was 1.08 pg/ml in the control rats, a value significantly lower than values obtained after the water load in rats deprived of glucocorticoid hormone for 1 day (2.5 +/- 0.2 pg/ml, P less than 0.01) and 14 days (2.4 +/- 0.3 pg/ml, P less than 0.01).	Water	20-25	arginine vasopressin	Rattus norvegicus	39-50
6247216-5	1980	Prolactin seems able to cause a prolonged reduction in water, sodium, and potassium excretion, a pattern that is imitated by no other hormone with the possible exception of growth hormone.	Water	55-60	prolactin	Homo sapiens	0-9
6247216-8	1980	This is particularly so with the effects of prolactin on water movements across fetal skin, the amniotic membrane, and in the eye where prolactin and vasopressin have diametrically opposite effects.	Water	57-62	prolactin	Homo sapiens	44-53
6247216-8	1980	This is particularly so with the effects of prolactin on water movements across fetal skin, the amniotic membrane, and in the eye where prolactin and vasopressin have diametrically opposite effects.	Water	57-62	prolactin	Homo sapiens	136-145
6247216-8	1980	This is particularly so with the effects of prolactin on water movements across fetal skin, the amniotic membrane, and in the eye where prolactin and vasopressin have diametrically opposite effects.	Water	57-62	arginine vasopressin	Homo sapiens	150-161
7386111-0	1980	Effects of intraventricular injection of Sar1-Ala8-angiotensin II on plasma vasopressin level increased by angiotensin II and by water deprivation in conscious rats.	Water	129-134	angiotensinogen	Rattus norvegicus	51-65
7373676-2	1980	However, the association of plasma ADH levels to the hemodynamic response and water and electrolyte balance of early thermal injury has not been defined.	Water	78-83	arginine vasopressin	Homo sapiens	35-38
7377376-1	1980	Activation of the renin-angiotensin system (RAS) or administration of angiotensin II (AII) will induce water intake.	Water	103-108	angiotensinogen	Rattus norvegicus	70-84
7377376-1	1980	Activation of the renin-angiotensin system (RAS) or administration of angiotensin II (AII) will induce water intake.	Water	103-108	angiotensinogen	Rattus norvegicus	86-89
7377572-6	1980	It is concluded that ADH excretion is increased during CPPV, and this could represent one possible mechanism of water retention with this type of ventilation.	Water	112-117	arginine vasopressin	Homo sapiens	21-24
6249399-0	1980	[Effect of deuterization and possible water molecule participation in cytochrome c oxidation].	Water	38-43	cytochrome c, somatic	Homo sapiens	70-82
7436414-0	1980	Solvation of lysozyme in water/dioxane mixtures studied in the frozen state by NMR spectroscopy.	Water	25-30	lysozyme	Homo sapiens	13-21
6245104-12	1980	The oxidation of methionine by the combination of H(2)O(2) and granular fractions was inhibited by (1)O(2) quenchers and MPO inhibitors, but it was stimulated by deuterium oxide.	Water	50-55	myeloperoxidase	Homo sapiens	121-124
7393974-3	1980	Exposure to the CS+ stimulated more drinking than comparable exposure to tap water following 2-8 differential conditioning trials (Experiment 1), following conditioning with lithium doses of 0.75-3.0 mEq/kg (Experiment 2), and in comparison with both exposure to water and exposure to the CS- (Experiment 3).	Water	77-82	nuclear RNA export factor 1	Rattus norvegicus	73-76
6245372-0	1980	Vasopressin increases water permeability in inducing pores.	Water	22-27	arginine vasopressin	Homo sapiens	0-11
6769337-4	1980	Tap water alone also induced a transient elevation in insulinemia but was much smaller than the saccharin-induced response.	Water	4-9	nuclear RNA export factor 1	Rattus norvegicus	0-3
6769337-5	1980	In streptozotocin diabetic rats bearing intrahepatic, presumably denervated islet isografts, these rapid insulin responses to oral saccharin and tap water stimulation were completely abolished, whereas the early insulin response to intravenous glucose was decreased by only about 30%.	Water	149-154	nuclear RNA export factor 1	Rattus norvegicus	145-148
7386111-0	1980	Effects of intraventricular injection of Sar1-Ala8-angiotensin II on plasma vasopressin level increased by angiotensin II and by water deprivation in conscious rats.	Water	129-134	arginine vasopressin	Rattus norvegicus	76-87
7386111-1	1980	The effects of intraventricular injection of Sar1-Ala8-angiotensin II (A specific antagonist of angiotensin II) on the plasma vasopressin level increased by intraventricular injection of angiotensin II and by water deprivation (46 h) were examined in conscious male rats with an indwelling cannula in the third cerebral ventricle.	Water	209-214	angiotensinogen	Rattus norvegicus	55-69
7386111-1	1980	The effects of intraventricular injection of Sar1-Ala8-angiotensin II (A specific antagonist of angiotensin II) on the plasma vasopressin level increased by intraventricular injection of angiotensin II and by water deprivation (46 h) were examined in conscious male rats with an indwelling cannula in the third cerebral ventricle.	Water	209-214	angiotensinogen	Rattus norvegicus	96-110
7386111-1	1980	The effects of intraventricular injection of Sar1-Ala8-angiotensin II (A specific antagonist of angiotensin II) on the plasma vasopressin level increased by intraventricular injection of angiotensin II and by water deprivation (46 h) were examined in conscious male rats with an indwelling cannula in the third cerebral ventricle.	Water	209-214	arginine vasopressin	Rattus norvegicus	126-137
7386111-1	1980	The effects of intraventricular injection of Sar1-Ala8-angiotensin II (A specific antagonist of angiotensin II) on the plasma vasopressin level increased by intraventricular injection of angiotensin II and by water deprivation (46 h) were examined in conscious male rats with an indwelling cannula in the third cerebral ventricle.	Water	209-214	angiotensinogen	Rattus norvegicus	96-110
7411436-4	1980	Long-term (7 day) infusions of angiotensin II into the third cerebral ventricle at rates of 1 or 10 pmol h-1 produced large and sustained increases in intake of water and 2 .	Water	161-166	angiotensinogen	Rattus norvegicus	31-45
7353759-0	1980	Effect of VIP infusion in water and ion transport in the human jejunum.	Water	26-31	vasoactive intestinal peptide	Homo sapiens	10-13
7353759-7	1980	At these levels VIP caused a dose-dependent decrease of water and sodium absorption.	Water	56-61	vasoactive intestinal peptide	Homo sapiens	16-19
7353759-11	1980	Our observations suggest that elevated levels of circulating VIP are capable of affecting water and ion movement in the human jejunum.	Water	90-95	vasoactive intestinal peptide	Homo sapiens	61-64
7365004-1	1980	The results of three experiments indicated that male hooded rats exhibit marked corticosterone elevations when they freely consume .740 mol/l (23.2% w/w) sucrose in tap water while nondeprived or .298 mol/l (9.8% w/w) sucrose when deprived of water for 36 hr.	Water	169-174	nuclear RNA export factor 1	Rattus norvegicus	165-168
7365004-3	1980	Free ingestion of tap water following sucrose consumption accelerated the decline from peak level of corticosterone during the period 60-120 min following the onset of sucrose consumption.	Water	22-27	nuclear RNA export factor 1	Rattus norvegicus	18-21
7378935-4	1980	Alcohol intoxication in conjunction with cold water immersion caused a further large increase in urine flow to 8.03 mL min-1.	Water	46-51	CD59 molecule (CD59 blood group)	Homo sapiens	119-124
6992036-0	1980	[Simultaneous occurrence of diabetes insipidus and diabetes mellitus (treatment of water-electrolyte imbalance with a vasopressin analog)].	Water	83-88	arginine vasopressin	Homo sapiens	118-129
7413306-0	1980	[Insufficient water load elimination during administration of 1 (3-mercaptopropionic acid)-8-D-arginine vasopressin (adiuretin) in diabetes insipidus].	Water	14-19	arginine vasopressin	Homo sapiens	104-115
6987372-2	1980	Insulin diffusivity in the membranes was determined to be 1.0 x 10(-6) cm2/sec, which is in reasonable agreement with literature values for insulin diffusivity in water.	Water	163-168	insulin	Homo sapiens	0-7
7359219-5	1980	From 35 to 80 minutes after feeding the LPL activity released by heparin from hearts of the glucose fed animals decreased 85% compared to the LPL activity released from hearts of the control group fed water.	Water	201-206	lipoprotein lipase	Rattus norvegicus	40-43
18962657-5	1980	The experimental conditions are specified and some examples are given of application of HPLC to determination of water-soluble vitamins (B1, B2, C, PP, B6) and fat-soluble vitamins (non-saponifiable oils, vitamin A and its esters, cholecalciferol, ergocalciferol, and tocopherol and its acetate) in multivitamin formulations (solutions, suspensions, syrups, fatty excipients etc.	Water	113-118	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	137-154
6243997-14	1980	The time course and the dose-response curve of the kinase activation closely parallel vasopressin"s effect on osmotic water flow.	Water	118-123	arginine vasopressin	Homo sapiens	86-97
6766317-2	1980	This membrane structural modification appears to be a general prerequisite for the change in water permeability of vasopressin-sensitive epithelia.	Water	93-98	arginine vasopressin	Homo sapiens	115-126
7373937-0	1980	[Effects of guanine nucleotides on vasopressin-induced increment of water permeability of the toad bladder (author"s transl)].	Water	68-73	arginine vasopressin	Homo sapiens	35-46
6987372-2	1980	Insulin diffusivity in the membranes was determined to be 1.0 x 10(-6) cm2/sec, which is in reasonable agreement with literature values for insulin diffusivity in water.	Water	163-168	insulin	Homo sapiens	140-147
7011672-1	1980	Arginine vasopressin, the antidiuretic hormone in man, in low concentrations increases reabsorption of water in the collecting ducts of the kidney, producing a concentrated urine.	Water	103-108	arginine vasopressin	Homo sapiens	9-20
7353030-10	1980	These residues are located at the end of two beta-sheet hydrophobic regions(49--57 and 77--85) which might play a role in the association of colipase with the lipid-water interface as indicated by results of the NMR studies of the taurodeoxycholate-colipase complex.	Water	165-170	colipase	Homo sapiens	141-149
7011672-1	1980	Arginine vasopressin, the antidiuretic hormone in man, in low concentrations increases reabsorption of water in the collecting ducts of the kidney, producing a concentrated urine.	Water	103-108	arginine vasopressin	Homo sapiens	26-46
7188925-10	1980	Vasopressin did not change the PRL plasma profile despite a significant (p less than 0.05) reduction in the excretion of free water.	Water	126-131	arginine vasopressin	Homo sapiens	0-11
6244155-2	1980	The water-soluble form of dopamine beta-monooxygenase from bovine adrenal medulla was studied.	Water	4-9	dopamine beta-hydroxylase	Bos taurus	26-53
6457847-6	1980	Measured in this system, the circulating levels of plasma vasopressin, in healthy adults after 18h dehydration, was 4.0 +/- 0.3 pg/ml (mean +/- SEM; n = 4) and fell to 0.6 +/- 0.1 pg/ml following a water load.	Water	198-203	arginine vasopressin	Rattus norvegicus	58-69
7222922-3	1980	A miracidium/snail density of 10:10 in 18 litres of water gave rise to an average level of parasitisation of 21%.	Water	52-57	snail family transcriptional repressor 1	Homo sapiens	13-18
230834-0	1979	Alterations in lactoperoxidase-catalyzed radio-iodination of membrane proteins associated with vasopressin-induced changes in tissue permeability to water.	Water	149-154	arginine vasopressin	Homo sapiens	95-106
7433539-3	1980	Small but statistically significance correlations between water content and 1/T1 or 1/T2 value were observed.	Water	58-63	brachyury, T-box transcription factor T	Mus musculus	78-85
391702-1	1979	Lipopolysaccharide (LPS) was prepared by phenol/water extraction of bacterial membranes prepared from Acinetobacter and Escherichia coli.	Water	48-53	toll-like receptor 4	Mus musculus	20-23
93026-1	1979	HLA-A and HLA-B antigens are integral membrane glycoproteins which consist of a glycosylated heavy chain embedded in the membrane in noncovalent association with beta 2-microglobulin, a water-soluble polypeptide.	Water	186-191	major histocompatibility complex, class I, A	Homo sapiens	0-5
547025-2	1979	Cl02 and metabolites, chlorite (Cl0-2) and chlorate (Cl0-3) in drinking water produced decreases in rat and chicken blood GSH.	Water	72-77	calpain 8	Rattus norvegicus	32-37
547025-2	1979	Cl02 and metabolites, chlorite (Cl0-2) and chlorate (Cl0-3) in drinking water produced decreases in rat and chicken blood GSH.	Water	72-77	calpain 8	Rattus norvegicus	53-58
510507-1	1979	The ingestion of 2 different water loads (7.5 and 15 ml/kg) by healthy subjects stimulated the release of plasma motilin, gastrin, pancreatic polypeptide and VIP.	Water	29-34	vasoactive intestinal peptide	Homo sapiens	158-161
231100-9	1979	Saralasin acetate (P-113), a competitive inhibitor of angiotensin II, given into the third brain ventricle, prevented the isoprenaline-induced NaCl and water intake as well as angiotensin II-induced drinking.	Water	152-157	angiotensinogen	Rattus norvegicus	54-68
544755-0	1979	[Absorption of bovine serum albumin at air-water interface and penetration into lipid monolayers (author"s transl)].	Water	43-48	albumin	Homo sapiens	22-35
42524-0	1979	Survival of El Tor cholera vibrio in local water sources and beverages in Tanzania.	Water	43-48	RAR related orphan receptor C	Homo sapiens	15-18
226536-0	1979	The effect of cytochrome P-450cam on the NMR relaxation rate of water protons.	Water	64-69	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	14-30
226536-1	1979	Cytochrome P-450cam in the native, substrate-free state (Fe3+, S = 1/2) substantially reduces the NMR relaxation times, T1 and T2, of water protons.	Water	134-139	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
494268-5	1979	Statistically significant factors controlling the resting PRA were delta PRA/removed-sodium, delta PRA//removed-water, and serum sodium concentration.	Water	112-117	S100 calcium binding protein A6	Homo sapiens	58-61
226714-2	1979	Urea and water transport across the toad bladder can be separately activated by low concentrations of vasopressin or 8 Br-cAMP.	Water	9-14	arginine vasopressin	Homo sapiens	102-113
494268-7	1979	2)Post-dialysis PRA was significantly correlated to the resting PRA, delta PRA/removed-sodium, delta PRA/removed-water, serum sodium concentration, and age, but not to the blood pressure indices.	Water	113-118	S100 calcium binding protein A6	Homo sapiens	16-19
474598-5	1979	The etiology of the inappropriate secretion of ADH is not obvious but is not thought to be due to "resetting of osmoreceptors" as evidenced by failure to maximally dilute urine following a water load test and persistently elevated serum ADH levels.	Water	189-194	arginine vasopressin	Homo sapiens	47-50
474757-2	1979	The hamsters were permitted free access to food and water or fasted for 16 h. PTH caused a phosphaturia in the fed hamster (fractional excretion of phosphate (FEPO4) increased from 5.8 +/- 1.3 to 27.4 +/- 4.6%, P less than 0.001) but not in the fasted hamster (from 9.9 +/- 2.5 to 12.4 +/- 2.5%, NS), whereas calcium excretion decreased significantly in both groups.	Water	52-57	parathyroid hormone	Rattus norvegicus	78-81
315865-1	1979	The effect of synthetic melanocyte-stimulating hormones (MSH) on urinary excretion of sodiu, potassium and water was studied in hamsters.	Water	107-112	proopiomelanocortin	Homo sapiens	57-60
488464-0	1979	[Sensitivity to insulin during adaptation to mineral water taken internally].	Water	53-58	insulin	Homo sapiens	16-23
494268-4	1979	1)Resting PRA (pre-dialysis PRA) was positively correlated to delta PRA/removed-sodium, delta PRA/removed-water, serum osmolality, and diastolic blood pressure, but negatively to serum sodium concentration, age, and pulse pressure/diastolic blood pressure.	Water	106-111	S100 calcium binding protein A6	Homo sapiens	10-13
494268-4	1979	1)Resting PRA (pre-dialysis PRA) was positively correlated to delta PRA/removed-sodium, delta PRA/removed-water, serum osmolality, and diastolic blood pressure, but negatively to serum sodium concentration, age, and pulse pressure/diastolic blood pressure.	Water	106-111	S100 calcium binding protein A6	Homo sapiens	28-31
494268-4	1979	1)Resting PRA (pre-dialysis PRA) was positively correlated to delta PRA/removed-sodium, delta PRA/removed-water, serum osmolality, and diastolic blood pressure, but negatively to serum sodium concentration, age, and pulse pressure/diastolic blood pressure.	Water	106-111	S100 calcium binding protein A6	Homo sapiens	28-31
494268-4	1979	1)Resting PRA (pre-dialysis PRA) was positively correlated to delta PRA/removed-sodium, delta PRA/removed-water, serum osmolality, and diastolic blood pressure, but negatively to serum sodium concentration, age, and pulse pressure/diastolic blood pressure.	Water	106-111	S100 calcium binding protein A6	Homo sapiens	28-31
487362-1	1979	Water-insoluble, non-adherent alpha-D-glucans have been obtained from Streptococcus salivarius HHT under two sets of conditions: from a growing culture, or synthesized enzymically by using a glucosyltransferase.	Water	0-5	SSAL8618_RS07090	Streptococcus salivarius	191-210
469152-7	1979	The age-related decrease of plasma renin activity is discussed on the light of the age-related impairment in the ability of the kidney to excrete sodium and water.	Water	157-162	renin	Homo sapiens	35-40
226714-6	1979	When water transport was activated (0.1 mM 8 Br-cAMP) sigma urea approached 1.0 sigma urea also approached 1.0 at high vasopressin concentrations.	Water	5-10	arginine vasopressin	Homo sapiens	119-130
28309661-1	1979	Three methods of fog-water uptake have been observed in three tribes of Namib desert dune tenebrionid beetles, Adesmiini, Eurychorini and Zophosini.	Water	21-26	zinc finger protein, FOG family member 1	Homo sapiens	17-20
501907-0	1979	Body fluid balance and fractional excretions of sodium, inorganic phosphorus, potassium and free water in low renin essential hypertension.	Water	97-102	renin	Homo sapiens	110-115
28309661-3	1979	Of the three methods described, none involve obvious fine anatomical or physical adaptations of the beetles for fog-water uptake.	Water	116-121	zinc finger protein, FOG family member 1	Homo sapiens	112-115
512941-0	1979	Renin, antidiuretic hormone and the kidney in water restriction and rehydration.	Water	46-51	renin	Ovis aries	0-5
515729-5	1979	An analysis has been made of the correlation between esophageal cancer as well as severe epithelial hyperplasia of the esophagus and the concentrations of NO3- and NO2- in the drinking water.	Water	185-190	NBL1, DAN family BMP antagonist	Homo sapiens	155-158
28309661-4	1979	Rather, the beetles have evolved specific behavioural patterns for drinking water condensed on vegetation, their own dorsum or sand.Use of fog-water necessitates surface activity at times when surface temperatures and wind velocities are not optimal for these diurnal or crepuscular species.	Water	76-81	zinc finger protein, FOG family member 1	Homo sapiens	139-142
515729-8	1979	Severe epithelial hyperplasia is defintely connected with the contents of NO2- and NO3- in the drinking water collected in spring, autumn and winter.	Water	104-109	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
512941-4	1979	Water restriction increased the plasma renin concentration and the plasma ADH concentration.	Water	0-5	renin	Ovis aries	39-44
512941-6	1979	Rehydration with water caused a further rise in plasma renin, but plasma ADH returned to basal levels in less than 2 hr.	Water	17-22	renin	Ovis aries	55-60
456315-2	1979	Nicotinic blocking agents, hexamethonium, tetraethylammonium chloride, and trimethaphan, blocked VP release in response to the addition of sufficient NaCl to yield a 10 mosm/kg H2O increase in culture medium osmolality.	Water	177-180	arginine vasopressin	Rattus norvegicus	97-99
524529-14	1979	It thus appears that, although there is a small osmotic component, the observed diuresis is primarily due to the ADH-independent inhibition of fre water reabsorption from the collecting duct by means of a mechanism yet to be identified.	Water	147-152	arginine vasopressin	Homo sapiens	113-116
112678-0	1979	Temperature dependence of ADH-induced water flow and intramembranous particle aggregates in toad bladder.	Water	38-43	arginine vasopressin	Homo sapiens	26-29
112678-1	1979	Antidiuretic hormone (ADH)-induced luminal intramembranous particle aggregates and hormonally stimulated water flow in toad urinary bladder are reduced simultaneously with a reduction in temperature.	Water	105-110	arginine vasopressin	Homo sapiens	0-20
112678-1	1979	Antidiuretic hormone (ADH)-induced luminal intramembranous particle aggregates and hormonally stimulated water flow in toad urinary bladder are reduced simultaneously with a reduction in temperature.	Water	105-110	arginine vasopressin	Homo sapiens	22-25
473258-1	1979	The possibility of radioprotective action of K and Mg aspartate administered in tap water for ten days prior to X-irradiation was investigated in male mice of the strain C 57 Bl/10.	Water	84-89	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	80-83
223821-2	1979	Intravenous infusion of VIP (14.3 microgram/kg/hr) inhibited net absorption of water and electrolytes in the ileum and reversed net absorption to net secretion in the colon.	Water	79-84	vasoactive intestinal peptide	Rattus norvegicus	24-27
483301-3	1979	Water deprivation tests showed clear evidence of antidiuretic hormone (ADH) secretion.	Water	0-5	arginine vasopressin	Homo sapiens	49-69
490626-0	1979	Metabolic dependence of the offset of antidiuretic hormone-induced osmotic flow of water across the toad urinary bladder.	Water	83-88	arginine vasopressin	Homo sapiens	38-58
490626-1	1979	The elevated osmotic permeability to water induced by antidiuretic hormone (ADH) in the isolated urinary bladder of the toad is rapidly reversed by removal or washout of the ADH.	Water	37-42	arginine vasopressin	Homo sapiens	54-74
490626-1	1979	The elevated osmotic permeability to water induced by antidiuretic hormone (ADH) in the isolated urinary bladder of the toad is rapidly reversed by removal or washout of the ADH.	Water	37-42	arginine vasopressin	Homo sapiens	76-79
490626-1	1979	The elevated osmotic permeability to water induced by antidiuretic hormone (ADH) in the isolated urinary bladder of the toad is rapidly reversed by removal or washout of the ADH.	Water	37-42	arginine vasopressin	Homo sapiens	174-177
490626-4	1979	When considered within constraints imposed by models which predict ADH"s action on water permeability to be either via modulation of the fluidity of lipids in the membrane or via the figuration of proteins ("pores") in the lipid membrane, these observations on the inhibition of the reversal of ADH stimulation of water flow are more consistent with the protein (pore) theory and place limitations on the mechanisms by which proteins in such pores can return to the resting or impermeable state.	Water	83-88	arginine vasopressin	Homo sapiens	67-70
483301-3	1979	Water deprivation tests showed clear evidence of antidiuretic hormone (ADH) secretion.	Water	0-5	arginine vasopressin	Homo sapiens	71-74
490626-4	1979	When considered within constraints imposed by models which predict ADH"s action on water permeability to be either via modulation of the fluidity of lipids in the membrane or via the figuration of proteins ("pores") in the lipid membrane, these observations on the inhibition of the reversal of ADH stimulation of water flow are more consistent with the protein (pore) theory and place limitations on the mechanisms by which proteins in such pores can return to the resting or impermeable state.	Water	314-319	arginine vasopressin	Homo sapiens	67-70
38829-0	1979	Regulation of the interaction of pancreatic phospholipase A2 with lipid-water interfaces by Ca2+ ions: a monolayer study.	Water	72-77	phospholipase A2 group IB	Homo sapiens	44-60
463918-7	1979	The water load significantly reduced urinary arginine vasopressin in normal women in both positions, but in those with idiopathic edema only in the supine position.	Water	4-9	arginine vasopressin	Homo sapiens	54-65
573135-0	1979	Regulation of phospholipase A2 activity by the lipid-water interface: a monolayer approach.	Water	53-58	phospholipase A2 group IB	Homo sapiens	14-30
573136-1	1979	Previously it has been shown that the binding of porcine pancreatic phospholipase A2 to lipid-water interfaces is governed by the pK of the alpha-NH3+ group of the N-terminal alanine.	Water	94-99	phospholipase A2 group IB	Homo sapiens	68-84
573136-7	1979	This second low-affinity Ca2+ binding site, which is also absent in [Gly1]phospholipase A2, is induced in the latter enzyme by the presence of lipid-water interfaces.	Water	149-154	phospholipase A2 group IB	Homo sapiens	74-90
223856-4	1979	Acute administration of either angiotensin I or angiotensin II (200 micrograms/kg body wt) was accompanied by a significant increase in water intake.	Water	136-141	angiotensinogen	Rattus norvegicus	48-62
444485-1	1979	Heat capacity of the lysozyme--water system.	Water	31-36	lysozyme	Homo sapiens	21-29
444485-2	1979	Calorimetric measurements of the heat capacity of the lysozyme-water system have been carried out over the full range of system composition at 25 degrees C. The partial specific heat capacity of the protein in dilute solution is 1.483 +/- 0.009 J K-1 g-1.	Water	63-68	lysozyme	Homo sapiens	54-62
444485-5	1979	The break in the heat capacity function at 0.38 h defines the amount of water needed to develop the equilibrium solution properties of lysozyme as being 300 molecules of water/protein molecule, just sufficient for monolayer coverage.	Water	72-77	lysozyme	Homo sapiens	135-143
444485-5	1979	The break in the heat capacity function at 0.38 h defines the amount of water needed to develop the equilibrium solution properties of lysozyme as being 300 molecules of water/protein molecule, just sufficient for monolayer coverage.	Water	170-175	lysozyme	Homo sapiens	135-143
109904-0	1979	Antagonism of vasopressin-induced water flow by somatostatin.	Water	34-39	arginine vasopressin	Homo sapiens	14-25
374720-2	1979	Pin height adjustment with an ultraspeed instrument using air-water coolant produces no potentially injurious heat generation.	Water	62-67	dynein light chain LC8-type 1	Homo sapiens	0-3
465363-6	1979	Both polycythaemic starved and polycythaemic water deprived rats injected with human urinary erythropoietin showed a 75% decrease in 59Fe incorporation into erythrocytes when compared to control rats.	Water	45-50	erythropoietin	Homo sapiens	93-107
37078-0	1979	270-MHz 1H nuclear-magnetic-resonance study of Met-enkephalin in water.	Water	65-70	proopiomelanocortin	Homo sapiens	47-61
219051-7	1979	This decrease of PGE in turn causes a reduction of plasma renin activity, possibly either by accelerating the retention of sodium and water or by failing to stimulate renin synthesis.	Water	134-139	renin	Homo sapiens	58-63
222336-0	1979	A novel method for converting apolipoprotein B, the major protein moiety of human plasma low density lipoproteins, into a water-soluble protein.	Water	122-127	apolipoprotein B	Homo sapiens	30-46
475753-3	1979	For glucose 6-phosphate dehydrogenase, hexokinase and fumarase, enzyme activity became detectable (about 0.05% of the fully hydrated rate) when the water content was about 0.2g/g of reaction mixture, and for phosphoglucose isomerase, around 0.15g/g of reaction mixture.	Water	148-153	hexokinase 1	Homo sapiens	39-49
452923-6	1979	When infusing small amounts of VIP a decrease of net water uptake was seen without any change of intestinal blood flow.	Water	53-58	vasoactive intestinal peptide	Homo sapiens	31-34
427107-0	1979	Thermodynamics of the denaturation of lysozyme in alcohol--water mixtures.	Water	59-64	lysozyme	Homo sapiens	38-46
216701-7	1979	It appears that apolipoprotein B is an easily degraded polypeptide with regions resembling water-soluble proteins but other regions which interact with lipid (or synthetic amphiphiles) and produce an overall insolubility in aqueous solution in the absence of amphiphilic ligands.	Water	91-96	apolipoprotein B	Homo sapiens	16-32
473074-4	1979	Month by month comparisons indicated that there were three statistically significant differences; all of which indicated improved performance for the mice that drank tap water.	Water	170-175	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	166-169
429103-2	1979	The D-Phe peptides, which are cleaved especially rapidly by thrombin in water, have structures (in deuterated DMSO) in which the aromatic ring of the D-Phe residue is folded back over the Val or Pip residue.	Water	72-77	coagulation factor II, thrombin	Homo sapiens	60-68
383365-1	1979	Arginine vasotocin, arginine vasopressin, and oxytocin play a critical role in the stimulation of labor and delivery and in salt and water homeostasis in the newborn infant.	Water	133-138	arginine vasopressin	Homo sapiens	29-40
426075-5	1979	The dose of exogenous angiotensin II (AII) producing 30 mmHg rise in blood pressure increased with the elevation of PRC, from 22 +/- 12 to 75 +/- 36 ng/kg, which was comparable to that in rats on water.	Water	196-201	angiotensinogen	Rattus norvegicus	22-36
426075-5	1979	The dose of exogenous angiotensin II (AII) producing 30 mmHg rise in blood pressure increased with the elevation of PRC, from 22 +/- 12 to 75 +/- 36 ng/kg, which was comparable to that in rats on water.	Water	196-201	angiotensinogen	Rattus norvegicus	38-41
426075-6	1979	The fall of blood pressure due to an AII inhibitor, [1-sarcosine, 8-alanine]AII (10(microgram/kg)/min for 40 min) became more prominent with the increase in PRC in salt-loaded rats, but was not detected in rats on water.	Water	214-219	angiotensinogen	Rattus norvegicus	37-40
426075-6	1979	The fall of blood pressure due to an AII inhibitor, [1-sarcosine, 8-alanine]AII (10(microgram/kg)/min for 40 min) became more prominent with the increase in PRC in salt-loaded rats, but was not detected in rats on water.	Water	214-219	angiotensinogen	Rattus norvegicus	76-79
434010-1	1979	The addition of ovine prolactin (oPRL) to the fetal side of human term amnion in vitro is associated with a decrease in membrane permeability to tritiated water (THO).	Water	155-160	prolactin	Homo sapiens	22-31
34812-8	1979	We think that the explanation of these phenomena could be a modification of renal water and electrolytes reabsorption, likely under the influence of antidiuretic hormone (ADH), stimulated in the hypothalamus and activated also by the beta-stimulant drug at tubular cell receptors.	Water	82-87	arginine vasopressin	Homo sapiens	149-169
219031-3	1979	Incubation of platelets with H(2)O(2) alone (20 muM H(2)O(2) for 10 min) resulted in a small, although significant, release of both serotonin and adenine, suggesting some platelet lysis.	Water	29-34	latexin	Homo sapiens	48-51
382050-0	1979	[Serum RIA vasopressin levels in 5 healthy subjects during water loading, before and during treatment by carbamazepine (author"s transl)].	Water	59-64	arginine vasopressin	Homo sapiens	11-22
382050-1	1979	Serum vasopressin level has been measured by radioimmunoassay in 5 healthy subjects during water loading, before and during treatment by carbamazepine.	Water	91-96	arginine vasopressin	Homo sapiens	6-17
34812-8	1979	We think that the explanation of these phenomena could be a modification of renal water and electrolytes reabsorption, likely under the influence of antidiuretic hormone (ADH), stimulated in the hypothalamus and activated also by the beta-stimulant drug at tubular cell receptors.	Water	82-87	arginine vasopressin	Homo sapiens	171-174
582889-8	1979	Representatives of some biotypes were most frequently isolated from surface water and from tap water prepared from surface water.	Water	95-100	SEC14 like lipid binding 2	Homo sapiens	91-94
113986-3	1979	Plasma vasopressin levels were excessively elevated, even during a water load test.	Water	67-72	arginine vasopressin	Homo sapiens	7-18
107810-1	1979	Intramembranous particle aggregates in the luminal membrane of toad bladder granular cells after vasopressin stimulation have been found to correlate closely and specifically with induced alterations of water permeability.	Water	203-208	arginine vasopressin	Homo sapiens	97-108
107810-3	1979	In the present investigation the effects of these agents on both initiating and sustaining vasopressin-induced osmotic water flow and the particle aggregation phenomenon were studied.	Water	119-124	arginine vasopressin	Homo sapiens	91-102
107810-4	1979	The results indicate that during initiation the aggregation and water flow responses to vasopressin are each colchicine- and cytochalasin B-sensitive and that these sensitivities can be wholly additive.	Water	64-69	arginine vasopressin	Homo sapiens	88-99
107810-6	1979	The findings, therefore, suggest that microtubules and microfilaments may be independently necessary for the initiation of the aggregation and water flow responses to vasopressin, and that microfilaments, but not microtubules, are required for their maintenance.	Water	143-148	arginine vasopressin	Homo sapiens	167-178
582889-0	1979	Characterization and classification of fluorescent pseudomonads isolated from tap water and surface water.	Water	82-87	SEC14 like lipid binding 2	Homo sapiens	78-81
582889-8	1979	Representatives of some biotypes were most frequently isolated from surface water and from tap water prepared from surface water.	Water	95-100	SEC14 like lipid binding 2	Homo sapiens	91-94
582889-9	1979	Tap water prepared from anaerobic or aerobic ground water contained representatives of biotypes which were typical of these water types.	Water	4-9	SEC14 like lipid binding 2	Homo sapiens	0-3
582889-9	1979	Tap water prepared from anaerobic or aerobic ground water contained representatives of biotypes which were typical of these water types.	Water	52-57	SEC14 like lipid binding 2	Homo sapiens	0-3
582889-9	1979	Tap water prepared from anaerobic or aerobic ground water contained representatives of biotypes which were typical of these water types.	Water	52-57	SEC14 like lipid binding 2	Homo sapiens	0-3
161182-0	1979	[Effects of water intake on variations of plasma renin activity (PRA) and blood aldosterone during physical exercise in man].	Water	12-17	renin	Homo sapiens	49-54
511011-3	1979	Under these conditions, the addition of alcohol to the drinking water decreases significantly both the platelet response to thrombin and the severity of atherosclerotic lesions without much affecting plasma cholesterol.	Water	64-69	coagulation factor II, thrombin	Homo sapiens	124-132
391545-2	1979	There is a parallel between water intake and plasma renin activity (PRA) in states like hypovolemia, hemorrhagia, hypotension, sodium loss, etc.	Water	28-33	renin	Homo sapiens	52-57
391545-4	1979	Water intake is increased after venous administration of angiotensin-II within physiological concentrations.	Water	0-5	angiotensinogen	Homo sapiens	57-71
222966-1	1979	Vasopressin increases the permeability of receptor cells to water and, in tissues such as toad bladder, to solutes such as urea.	Water	60-65	arginine vasopressin	Homo sapiens	0-11
43840-2	1979	HCl(Asc, aminosuccinyl), which transformed partially to cyclo[Leu-Asp(Phe-NH2)] during its purification by column chromatography on silica gel with a mixture of ethyl acetate/pyridine/acetic acid/water = 60:20:6:11, i.e. in neutral medium.	Water	196-201	PYD and CARD domain containing	Homo sapiens	4-7
222966-3	1979	In the present study, we have shown that inhibitors of oxidative metabolism (rotenone, dinitrophenol, and methylene blue) selectively inhibit either vasopressin-stimulated water flow or vasopressin-stimulated urea transport.	Water	172-177	arginine vasopressin	Homo sapiens	149-160
222966-7	1979	We would conclude that water and urea transport, as examples of hormone-stimulated processes, have different links to cell metabolism, and that in addition to cyclic AMP, a non-nucleotide pathway may be involved in the action of vasopressin.	Water	23-28	arginine vasopressin	Homo sapiens	229-240
710857-3	1978	When the VIP infusion was discontinued the water diarrhea ceased abruptly.	Water	43-48	vasoactive intestinal peptide	Homo sapiens	9-12
440532-0	1979	Central effects of angiotensin II in water and saline loaded rats.	Water	37-42	angiotensinogen	Rattus norvegicus	19-33
440532-1	1979	In unanesthetized water-loaded rats, intracerebroventricular (IVT) angiotensin II (AII) injections produce centrally mediated pressor effects and antidiuresis.	Water	18-23	angiotensinogen	Rattus norvegicus	67-81
440532-1	1979	In unanesthetized water-loaded rats, intracerebroventricular (IVT) angiotensin II (AII) injections produce centrally mediated pressor effects and antidiuresis.	Water	18-23	angiotensinogen	Rattus norvegicus	83-86
440532-4	1979	Central administration of AII in water and saline-loaded rats produced no change in effective renal plasma flow or glomerular filtration rate, Natriuretic and kaliuretic responses to IVT AII injections were similar to those observed to intravenous ADH infusions.	Water	33-38	angiotensinogen	Rattus norvegicus	26-29
286742-5	1979	The materials contain a small amount of hydrophobic cross linking agents in MMA indicate comparatively excellent properties after drying, water sorption and thermal cycling.	Water	138-143	monocyte to macrophage differentiation associated	Homo sapiens	76-79
727293-5	1978	Changes similar to those seen in ADH-treated rats were observed in water-deprived Wistar rats.	Water	67-72	arginine vasopressin	Homo sapiens	33-36
309823-3	1978	3 experimentally distinct transverse relaxation components of the water in frog sciatic nerve are obtained by Carr-Purcell-Meiboom-Gill technique.	Water	66-71	arrestin 3	Homo sapiens	110-114
667487-3	1978	Treated animals gained weight more slowly and consumed less food and water than control rats that drank tap water.	Water	108-113	nuclear RNA export factor 1	Rattus norvegicus	104-107
30650-4	1978	Recently, it has been shown that angiotensin II, infused intravenously or through the carotid artery at rates that produce increases in plasma angiotensin II levels similar to those that occur in mild sodium depletion, causes the water-replete animal to drink.	Water	230-235	angiotensinogen	Homo sapiens	33-47
30650-4	1978	Recently, it has been shown that angiotensin II, infused intravenously or through the carotid artery at rates that produce increases in plasma angiotensin II levels similar to those that occur in mild sodium depletion, causes the water-replete animal to drink.	Water	230-235	angiotensinogen	Homo sapiens	143-157
707572-1	1978	Induced water diuresis blocks the central release of antidiuretic hormone (ADH) which is, in turn, supposed to play a role in the high uterine activity recorded during human menstruation.	Water	8-13	arginine vasopressin	Homo sapiens	53-73
707572-1	1978	Induced water diuresis blocks the central release of antidiuretic hormone (ADH) which is, in turn, supposed to play a role in the high uterine activity recorded during human menstruation.	Water	8-13	arginine vasopressin	Homo sapiens	75-78
750489-2	1978	Twenty-four hour water deprived rats were habituated for two consecutive days to drinking tap water in the drinking box for 15 minutes daily.	Water	94-99	nuclear RNA export factor 1	Rattus norvegicus	90-93
278998-3	1978	(ii) Isolated detergent-soluble HLA-A and HLA-B antigens reconstituted in lipid vesicles inhibit the binding of viral proteins to human cells (as do the water-soluble antigens to a lesser extent).	Water	153-158	major histocompatibility complex, class I, A	Homo sapiens	32-37
9762085-3	1978	Although some proteins are denatured by this procedure, most of the water-soluble proteins remain in solution, including biotin-binding protein and riboflavin-binding protein.	Water	68-73	riboflavin binding protein	Gallus gallus	148-174
708175-6	1978	The low renin levels are consistent with other evidence that hypertension in these patients is related to salt and water retention.	Water	115-120	renin	Homo sapiens	8-13
744129-8	1978	It is concluded that elevated vasopressin in plasma may be an important factor in the incomplete water diuresis in adrenal insufficiency.	Water	97-102	arginine vasopressin	Rattus norvegicus	30-41
702523-9	1978	Addition of a crude preparation of fibrinogen in physiological amounts to isotonic saline and human serum albumin restores the cell water lifetime to a value similar to that observed in plasma.	Water	132-137	fibrinogen beta chain	Homo sapiens	35-45
100663-0	1978	Stimulative effect of guanylylimidodiphosphate on the vasopressin-induced increment of osmotic water flow of the toad bladder.	Water	95-100	arginine vasopressin	Homo sapiens	54-65
357658-1	1978	Guinea pig peritoneal exudate cells incubated with water soluble glycolipids obtained from macrophages show an enhanced response to migration inhibitory factor.	Water	51-56	macrophage migration inhibitory factor	Cavia porcellus	132-159
667133-0	1978	Formation of microsomal cytochrome P-450 complexes studied by the NMR relaxation of water.	Water	84-89	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	24-40
671346-7	1978	Net Na and H2O absorption were reversed to secretion by VIP at 175 ng/min due to a significant decrease in unidirectional absorptive fluxes and smaller increases in secretory fluxes.	Water	11-14	vasoactive intestinal peptide	Canis lupus familiaris	56-59
671347-6	1978	The peptide was particularly effective when water intake was induced by injections of Angiotensin II into the preoptic area.	Water	44-49	angiotensinogen	Rattus norvegicus	86-100
96270-3	1978	Colchicine, podophyllotoxin and vinblastine have been found to inhibit the action of vasopressin on water movement in the toad urinary bladder.	Water	100-105	arginine vasopressin	Homo sapiens	85-96
96270-9	1978	These results, coupled with those of functional and morphological studies, support the view that the ability of these drugs to affect vasopressin-induced water movement across toad bladder epithelial cells is related to the depolymerization of cytoplasmic microtubules.	Water	154-159	arginine vasopressin	Homo sapiens	134-145
207871-4	1978	Inhibition of vasopressin-induced water movement is half-maximal at the following alkaloid concentrations: colchicine, 1.8 X 10(-6) M; podophyllotoxin, 5 X 10(-7)M; and vinblastine, 1 X 10(-7)M. The characteristics of the specificity, time-dependence and temperature-dependence of the inhibitory effect of colchicine are similar to the characteristics of the interaction of this drug with tubulin in vitro, and they differ from those of its effect on nucleoside transport.	Water	34-39	arginine vasopressin	Homo sapiens	14-25
207871-6	1978	The findings support the view that the inhibition of vasopressin-induced water movement by the antimitotic agents is due to the interaction of these agents with tubulin and consequent interference with microtubule integrity and function.	Water	73-78	arginine vasopressin	Homo sapiens	53-64
207871-2	1978	The antimitotic agents colchicine, podophyllotoxin, and vinblastine inhibit the action of vasopressin and cyclic AMP on osmotic water movement in the toad urinary bladder.	Water	128-133	arginine vasopressin	Homo sapiens	90-101
207871-7	1978	Taken together with the results of biochemical and morphological studies, the findings provide evidence that cytoplasmic microtubules play a critical role in the action of vasopressin on transcellular water movement in the toad bladder.	Water	201-206	arginine vasopressin	Homo sapiens	172-183
207802-8	1978	Tryptic digestion for 1 hr at pH 7.6 with enzyme-to-protein ratios of 1:100 and 1:5 results in the liberation of approximately 10% and 30% of apoB as smaller, water-soluble peptides.	Water	159-164	apolipoprotein B	Homo sapiens	142-146
649661-5	1978	When water flux is increased by exposing the tissue to vasopressin, in the presence of an osmotic gradient across the tissue the microvilli on the granular cell lose the ridge structure and appear, predominantly, as individual projection.	Water	5-10	arginine vasopressin	Homo sapiens	55-66
649661-10	1978	We conclude that the changes in the mucosal surface morphology of the toad bladder seen after exposure to vasopressin are a result of the increased water flux that occurs when an osmotic gradient exists across the tissue, and are not related to the natriferic response or any specific alteration in the membrane properties.	Water	148-153	arginine vasopressin	Homo sapiens	106-117
645727-1	1978	The plasma vasopressin response to acute water ingestion was evaluated in 20 patients with myxedema prior to definitive treatment and in eight of these same patients following therapy of their hypothyroidism.	Water	41-46	arginine vasopressin	Homo sapiens	11-22
659596-2	1978	The effect of vasoactive intestinal polypeptide (VIP) on intestinal water and electrolyte transport and transmucosal potential difference was investigated in the dog jejunum in vivo and compared to secretion induced by cholera toxin.	Water	68-73	vasoactive intestinal peptide	Canis lupus familiaris	14-47
659596-2	1978	The effect of vasoactive intestinal polypeptide (VIP) on intestinal water and electrolyte transport and transmucosal potential difference was investigated in the dog jejunum in vivo and compared to secretion induced by cholera toxin.	Water	68-73	vasoactive intestinal peptide	Canis lupus familiaris	49-52
659596-5	1978	VIP caused secretion of water and electrolytes; for example, chloride: control, 8 mueq/cm per h absorption; VIP, 92 mueq/cm per h secretion.	Water	24-29	vasoactive intestinal peptide	Canis lupus familiaris	0-3
670450-2	1978	In these experiments PGE1, at a dose of 1 microgram, suppressed water intake induced by centrally administered angiotensin II (AII) or carbachol, subcutaneously administered polyethylene glycol, and water deprivation.	Water	64-69	angiotensinogen	Rattus norvegicus	111-125
670450-2	1978	In these experiments PGE1, at a dose of 1 microgram, suppressed water intake induced by centrally administered angiotensin II (AII) or carbachol, subcutaneously administered polyethylene glycol, and water deprivation.	Water	64-69	angiotensinogen	Rattus norvegicus	127-130
415801-0	1978	Regulation of brain water permeability by centrally-released vasopressin.	Water	20-25	arginine vasopressin	Homo sapiens	61-72
637803-4	1978	Plasma renin and aldosterone levels were significantly reduced in the subjects receiving the electrolyte supplement compared to subjects receiving only water.	Water	152-157	renin	Homo sapiens	7-12
75941-1	1978	The lipopolysaccharide (LPS)-protein complex extracted from the cell wall of Escherichia coli K235 by the butanol-water technique has been shown to evoke a mitogenic response in bone marrow-derived (B) lymphocytes from the C3H/HeJ mouse strain.	Water	114-119	toll-like receptor 4	Mus musculus	24-27
204321-1	1978	The use of perchloric acid and water for the extraction of CEA from tumour and foetal tissues has been investigated.	Water	31-36	CEA cell adhesion molecule 3	Homo sapiens	59-62
418180-0	1978	Vasopressin-like effects of a hallucinogenic drug--harmaline--on sodium and water transport.	Water	76-81	arginine vasopressin	Homo sapiens	0-11
639259-3	1978	The peroxide is reacted with ethanol in the presence of catalase to form acetaldehyde and water, and the acetaldehyde is reduced by NADH in the presence of alcohol dehydrogenase to ethanol.	Water	90-95	catalase	Homo sapiens	56-64
638840-1	1978	The conversion of [4-14C]estradiol to water-soluble products by lactoperoxidase (EC 1.11.1.7) in the presence of added or generated H2O2 was studied using albumin or tyrosine as acceptor.	Water	38-43	lactoperoxidase	Homo sapiens	64-79
344330-4	1978	Lowering the serosal calcium at the peak of the hydrosmotic responses to both ADH and A 23187 inhibited the maintenance of the net water flux.	Water	131-136	arginine vasopressin	Homo sapiens	78-81
344330-8	1978	It is suggested that calcium is involved in the action of ADH on water permeability and may act as a modulator of the hydrosmotic response.	Water	65-70	arginine vasopressin	Homo sapiens	58-61
204293-1	1978	By enzymic digestion of the polysaccharide part of the covalent complex between cytochrome c and Sephadex G-200, a new water-soluble cytochrome c derivative is obtained (called cytochrome cr).	Water	119-124	cytochrome c, somatic	Homo sapiens	80-92
204293-1	1978	By enzymic digestion of the polysaccharide part of the covalent complex between cytochrome c and Sephadex G-200, a new water-soluble cytochrome c derivative is obtained (called cytochrome cr).	Water	119-124	cytochrome c, somatic	Homo sapiens	133-145
416864-0	1978	Movement of PCB from a contaminated reservoir into a drinking water supply.	Water	62-67	pyruvate carboxylase	Homo sapiens	12-15
645727-3	1978	Two hypothyroid patients with elevated plasma vasopressin levels (10 per cent) had a normal renal response to the water challenge suggesting partial end organ hormonal unresponsiveness.	Water	114-119	arginine vasopressin	Homo sapiens	46-57
633132-0	1978	Sodium and water metabolism under the influence of prolactin, aldosterone, and antidiuretic hormone.	Water	11-16	prolactin	Oryctolagus cuniculus	51-60
205561-1	1978	In the toad urinary bladder 8-p-chlorophenylthio-cyclic AMP mimics the stimulatory effects of antidiuretic hormone on osmotic water permeability, 3H2O diffusion, and transepithelial sodium transport; but unlike the hormone does not cause an increase in urea permeability.	Water	126-131	adenine phosphoribosyltransferase	Homo sapiens	56-59
750607-1	1978	Previous studies from this laboratory have demonstrated that the redistribution of blood volume and concomitant central hypervolemia induced by water immersion to the neck (NI), produces a prompt and profound suppression of plasma renin activity (PRA) and plasma aldosterone concentration (PA) without concomitant alterations in serum sodium and potassium concentrations.	Water	144-149	renin	Homo sapiens	231-236
633132-13	1978	Prolactin (200 i.u./day) caused a reduction in urine volume and in renal sodium excretion and since there were no compensatory changes in water and sodium intake, this led to substantial accumulation of both water and sodium.	Water	208-213	prolactin	Oryctolagus cuniculus	0-9
356498-4	1978	Biliary water and electrolytes are augmented by gastrin, CCK-PZ, secretin and VIP and inhibited by Substance P.	Water	8-13	cholecystokinin	Homo sapiens	57-60
752211-1	1978	In preliminary experiments it had been shown that the total catecholamines in the urine of rats collected during 5 hrs after stimulation of diuresis with 50 ml tap water/kg body weight per os were not changed significantly following a 3-week training in individual metabolic cages, a short pressing of the animals against the laboratory table, a single i. p. injection of 2 ml sodium chloride solution (145 mmol/l)/kg body weight, or a single s. c. injection of 40 ml air per animal.	Water	164-169	nuclear RNA export factor 1	Rattus norvegicus	160-163
23154-0	1978	Effects of alcohol/water mixtures on the structure and reactivity of cytochrome c.	Water	19-24	cytochrome c, somatic	Homo sapiens	69-81
202313-2	1978	Redox potentials of ferro-ferricyanide and cytochrome c were measured in water/ethylene glycol and water/dimethylsulfoxide (volume ratio from 100/0 to 50/50) between 25 and -25 degrees C. For both systems, the midpoint potential decreases in the presence of organic solvents and increases by cooling.	Water	73-78	cytochrome c, somatic	Homo sapiens	43-55
202313-2	1978	Redox potentials of ferro-ferricyanide and cytochrome c were measured in water/ethylene glycol and water/dimethylsulfoxide (volume ratio from 100/0 to 50/50) between 25 and -25 degrees C. For both systems, the midpoint potential decreases in the presence of organic solvents and increases by cooling.	Water	99-104	cytochrome c, somatic	Homo sapiens	43-55
356498-4	1978	Biliary water and electrolytes are augmented by gastrin, CCK-PZ, secretin and VIP and inhibited by Substance P.	Water	8-13	vasoactive intestinal peptide	Homo sapiens	78-81
356498-4	1978	Biliary water and electrolytes are augmented by gastrin, CCK-PZ, secretin and VIP and inhibited by Substance P.	Water	8-13	tachykinin precursor 1	Homo sapiens	99-110
655001-0	1978	Interaction of phospholipase A2 with lipid-water interfaces.	Water	43-48	phospholipase A2 group IB	Homo sapiens	15-31
665379-1	1978	1) Lipophilic ganglioside GD1a (IV3NeuAc, II3NeuAc-GgOse4-Cer) is taken up by the cell membranes and hydrolyzed faster by membrane-bound neuraminidase than are water soluble substrates of the enzyme.	Water	160-165	neuraminidase 1	Bos taurus	137-150
555326-5	1978	On the basis of these results it is surmised that prolactin is continuously synthesized and released into the circulation in Xenopus specimens kept or replaced in water, thereby contributing to the animals adaptation to the aquatic environment, whereas in those kept under waterless condition prolactin synthesis is not discontinued, but its release into the bloodstream declines or is abolished.	Water	163-168	prolactin, gene 2 L homeolog	Xenopus laevis	50-59
203196-0	1978	Inhibition of drinking in water-deprived rats by combined central angiotensin II and cholinergic receptor blockade.	Water	26-31	angiotensinogen	Rattus norvegicus	66-80
639548-3	1978	The increase in dominant lethal mutations in treated animals as compared to tap water controls is significant at the 1% level.	Water	80-85	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	76-79
215771-0	1978	Role of prostaglandin E (PGE) in the modulation of the action of vasopressin on water flow in the urinary bladder of the toad and mammalian kidney.	Water	80-85	arginine vasopressin	Homo sapiens	65-76
215771-1	1978	PGE1 and PGE2 are known to interfere with the water permeability effect of vasopressin in toad bladder and kidney.	Water	46-51	arginine vasopressin	Homo sapiens	75-86
215771-4	1978	In the latter, inhibition of vasopressin-induced synthesis of PGE by a variety of inhibitors results in a greater water permeability response to vasopressin.	Water	114-119	arginine vasopressin	Homo sapiens	29-40
215771-4	1978	In the latter, inhibition of vasopressin-induced synthesis of PGE by a variety of inhibitors results in a greater water permeability response to vasopressin.	Water	114-119	arginine vasopressin	Homo sapiens	145-156
732944-0	1978	Evolution of vasopressin levels in the hypothalamo-posthypophysial system of the rat during rehydration following water deprivation.	Water	114-119	arginine vasopressin	Rattus norvegicus	13-24
351326-0	1978	Carbohydrate antigens: coupling melibionic acid to bovine serum albumin using water-soluble carbodiimide.	Water	78-83	albumin	Homo sapiens	58-71
199620-8	1977	Neither cyclic AMP nor theophylline stimulated PGE biosynthesis although they mimic arginine vasopressin (AVP) in stimulating water permeability.	Water	126-131	arginine vasopressin	Homo sapiens	93-104
563922-0	1977	Formation, structure, and spectrophotometry of air-water interface films containing rhodopsin.	Water	51-56	rhodopsin	Homo sapiens	84-93
214801-0	1978	Electron reactions with cytochrome c in ethylene glycol/water glass at-196 degrees C. Low temperature gamma-irradiation and spectroscopy are used to study electron reactions with cytochrome c in aquo organic glass at-196 degrees C. Spectral data suggests that cytochrome c is reduced by electron at 196 degrees C. Raising the glass temperature reveals further changes in spectrum, suggesting that conformational changes may occur in cytochrome c molecule during stabilization of reductive process.	Water	56-61	cytochrome c, somatic	Homo sapiens	24-36
214801-0	1978	Electron reactions with cytochrome c in ethylene glycol/water glass at-196 degrees C. Low temperature gamma-irradiation and spectroscopy are used to study electron reactions with cytochrome c in aquo organic glass at-196 degrees C. Spectral data suggests that cytochrome c is reduced by electron at 196 degrees C. Raising the glass temperature reveals further changes in spectrum, suggesting that conformational changes may occur in cytochrome c molecule during stabilization of reductive process.	Water	56-61	cytochrome c, somatic	Homo sapiens	179-191
214801-0	1978	Electron reactions with cytochrome c in ethylene glycol/water glass at-196 degrees C. Low temperature gamma-irradiation and spectroscopy are used to study electron reactions with cytochrome c in aquo organic glass at-196 degrees C. Spectral data suggests that cytochrome c is reduced by electron at 196 degrees C. Raising the glass temperature reveals further changes in spectrum, suggesting that conformational changes may occur in cytochrome c molecule during stabilization of reductive process.	Water	56-61	cytochrome c, somatic	Homo sapiens	179-191
214801-0	1978	Electron reactions with cytochrome c in ethylene glycol/water glass at-196 degrees C. Low temperature gamma-irradiation and spectroscopy are used to study electron reactions with cytochrome c in aquo organic glass at-196 degrees C. Spectral data suggests that cytochrome c is reduced by electron at 196 degrees C. Raising the glass temperature reveals further changes in spectrum, suggesting that conformational changes may occur in cytochrome c molecule during stabilization of reductive process.	Water	56-61	cytochrome c, somatic	Homo sapiens	179-191
199621-7	1977	We conclude that the mechanism of enhancement on vasopressin-stimulated water flow by the sulfonylureas is the inhibition of prostaglandin E biosynthesis.	Water	72-77	arginine vasopressin	Homo sapiens	49-60
199620-10	1977	The inhibition of PGE biosynthesis resulted in augmented vasopressin- and theophylline-stimulated water flow, but had no effect on cyclic AMP-stimulated water flow.	Water	98-103	arginine vasopressin	Homo sapiens	57-68
199620-13	1977	The water permeability response of the toad urinary bladder to vasopressin is inhibited by PGE synthesized by the bladder in response to vasopressin.	Water	4-9	arginine vasopressin	Homo sapiens	63-74
199620-13	1977	The water permeability response of the toad urinary bladder to vasopressin is inhibited by PGE synthesized by the bladder in response to vasopressin.	Water	4-9	arginine vasopressin	Homo sapiens	137-148
199621-1	1977	Mechanism of enhancement of vasopressin-stimulated water flow.	Water	51-56	arginine vasopressin	Homo sapiens	28-39
199621-2	1977	Chlorpropamide is known to enhance the water permeability response of the toad urinary bladder to vasopressin and to theophylline.	Water	39-44	arginine vasopressin	Homo sapiens	98-109
199621-3	1977	In other studies, we have shown that prostaglandin E synthesis by the toad bladder inhibits the water permeability response to arginine vasopressin and to theophylline.	Water	96-101	arginine vasopressin	Homo sapiens	136-147
199621-4	1977	In this study, the effect of chlorpropamide on vasopressin-, theophylline-, and cyclic AMP-stimulated water flow and on prostaglandin E biosynthesis was investigated in the toad urinary bladder in vitro.	Water	102-107	arginine vasopressin	Homo sapiens	47-58
199621-5	1977	Chlorpropamide inhibited prostaglandin E biosynthesis during vasopressin-, theophylline- and cyclic AMP-stimulated water flow.	Water	115-120	arginine vasopressin	Homo sapiens	61-72
199621-6	1977	Tolbutamide and glyburide, two other sulfonylurea compounds, also enhanced vasopressin-stimulated water flow and inhibited vasopressin-stimulated prostaglandin E biosynthesis.	Water	98-103	arginine vasopressin	Homo sapiens	75-86
202919-6	1977	These results strongly suggest that, a) neurohypophyseal hormones not only increase Na entry across the mucosal barrier of the epithelium but they also stimulate the serosal Na pump, b) cyclic AMP not only mediates the action of neurohypophyseal hormones on Na and water permeability of the mucosal barrier, but it also mediates the action of the hormones on the Na pump of the serosal barrier.	Water	265-270	arginine vasopressin	Homo sapiens	40-56
202919-6	1977	These results strongly suggest that, a) neurohypophyseal hormones not only increase Na entry across the mucosal barrier of the epithelium but they also stimulate the serosal Na pump, b) cyclic AMP not only mediates the action of neurohypophyseal hormones on Na and water permeability of the mucosal barrier, but it also mediates the action of the hormones on the Na pump of the serosal barrier.	Water	265-270	arginine vasopressin	Homo sapiens	229-245
412766-1	1977	The effect of TRH induced secretion of TSH and prolactin (hPrl) on plasma renin activity (PRA), water and electrolyte excretion, was studied in 7 normal males before and after an intravenous injection of 2 ml normal saline or 200 microgram TRH.	Water	96-101	prolactin	Homo sapiens	58-62
603306-2	1977	Bradykinin, when injected into the renal artery of the dog, reduced the proximal reabsorption of sodium and water and decreased the secretion of p-aminohippuric acid (PAH).	Water	108-113	kininogen 1	Canis lupus familiaris	0-10
612134-0	1977	The effect of intraventricular 6-hydroxydopamine on the content of oxytocin and vasopressin in the hypothalamus and pituitary gland of water-deprived rats.	Water	135-140	arginine vasopressin	Rattus norvegicus	80-91
612134-1	1977	The effect of intraventricular 6-hydroxydopamine on the content of oxytocin and vasopressin in the hypothalamus and pituitary gland of water deprived rats.	Water	135-140	arginine vasopressin	Rattus norvegicus	80-91
915435-2	1977	Subjects infused with either the D solution or tap water immediately before backward conditioning learned weaker saccharin aversions than animals infused with the ND solution and animals given no infusion at this time (Experiments 1 and 3).	Water	51-56	nuclear RNA export factor 1	Rattus norvegicus	47-50
902688-0	1977	Effect of bradykinin on the renal medullary osmotic gradient in water diuresis.	Water	64-69	kininogen 1	Canis lupus familiaris	10-20
613398-0	1977	[Role of antidiuretic hormone (ADH) in the regulation of water and electrolyte elimination in patients with diabetes mellitus].	Water	57-62	arginine vasopressin	Homo sapiens	9-29
613398-0	1977	[Role of antidiuretic hormone (ADH) in the regulation of water and electrolyte elimination in patients with diabetes mellitus].	Water	57-62	arginine vasopressin	Homo sapiens	31-34
914974-1	1977	The threshold of serum osmolality causing release of vasopressin (antidiuretic hormone) was shifted to an abnormally low level (262 mosmol/kg H2O) in a 14-year-old girl with hypertension and signs of hypoplastic corpus callosum.	Water	142-145	arginine vasopressin	Homo sapiens	53-86
914974-2	1977	There was a physiologically meaningful control of vasopressin release in response to water restriction and water load.	Water	85-90	arginine vasopressin	Homo sapiens	50-61
914974-2	1977	There was a physiologically meaningful control of vasopressin release in response to water restriction and water load.	Water	107-112	arginine vasopressin	Homo sapiens	50-61
902688-3	1977	Bradykinin decreased the total osmolality per kg H2O in tissue from inner medulla and papilla (-18.7 +/- 6% and -19.3 +/- 8%) and increased fractional water excretion (3.8 +/- 1.3%).	Water	49-52	kininogen 1	Canis lupus familiaris	0-10
902688-7	1977	Thus, a bradykinin-induced increase in free water clearance may be accounted for by other than an inhibition of proximal tubular sodium reabsorption.	Water	44-49	kininogen 1	Canis lupus familiaris	8-18
910906-9	1977	These results indicate that insulin-requiring diabetics absorb glucose, Na, and H2O normally.	Water	80-83	insulin	Homo sapiens	28-35
17753336-1	1977	Lectin is released from soybean seeds during water uptake.	Water	45-50	LOW QUALITY PROTEIN: lectin	Glycine max	0-6
902688-3	1977	Bradykinin decreased the total osmolality per kg H2O in tissue from inner medulla and papilla (-18.7 +/- 6% and -19.3 +/- 8%) and increased fractional water excretion (3.8 +/- 1.3%).	Water	151-156	kininogen 1	Canis lupus familiaris	0-10
902688-6	1977	These results indicate that bradykinin can diminish the medullary osmotic gradient during water diuresis in the dog.	Water	90-95	kininogen 1	Canis lupus familiaris	28-38
875472-2	1977	The rats were on a regular rat chow diet (0.45% sodium content) and tap water and were not hypertensive at the time of the study.	Water	72-77	nuclear RNA export factor 1	Rattus norvegicus	68-71
562405-13	1977	The firing rate of both oxytocin and vasopressin cells decreased when plasma osmotic pressure was reduced 10-15 m-osmole/kg by an intragastric water load of 10 ml.6.	Water	143-148	arginine vasopressin	Homo sapiens	37-48
877549-1	1977	Cerebroventricular infusion of P-113, the blocking agent of angiotensin II, into rats for 75 minutes prior to their being allowed to drink, significantly attenuated their water intake when they had been deprived of water for 30 hours.	Water	171-176	angiotensinogen	Rattus norvegicus	60-74
877549-1	1977	Cerebroventricular infusion of P-113, the blocking agent of angiotensin II, into rats for 75 minutes prior to their being allowed to drink, significantly attenuated their water intake when they had been deprived of water for 30 hours.	Water	215-220	angiotensinogen	Rattus norvegicus	60-74
877549-3	1977	The results indicate a physiological role for angiotensin II in the drinking response of rats deprived of water.	Water	106-111	angiotensinogen	Rattus norvegicus	46-60
19495-1	1977	Resolution of the water-soluble vitamins--pyridoxin, riboflavin, niacinamide, vitamin B12, thiamin, ascorbic acid, niacin and folic acid--by high pressure liquid chromatography was examined on two bonded-phase columns, muBondapak C18 and muBondapak NH2.	Water	18-23	Bardet-Biedl syndrome 9	Homo sapiens	230-233
884985-6	1977	Since the blood PN2 is a measure of the nitrogen dissolved in the water of the plasma, these studies show that tonometrically analyzed water is a valid standard of calibration for this mass-spectrometric method of determining the blood PN2.	Water	135-140	amyloid beta precursor protein	Homo sapiens	236-239
874078-2	1977	We investigated the relationship of the kallikrein-kinin system and the renin-angiotensin system in the regulation of blood pressure, salt and water excretion, and renal blood flow.	Water	143-148	renin	Homo sapiens	72-77
890049-2	1977	The properties of an air-water interface film of spectroscopically intact and chemically regenerable rhodopsin are presented, and results of studies of ion binding to these films are reported.	Water	25-30	rhodopsin	Homo sapiens	101-110
19604991-3	1977	Even after a delay of 1.0 h, A-II-injected animals showed increased water consumption compared to controls.	Water	68-73	angiotensinogen	Homo sapiens	29-33
19604991-4	1977	Animals injected with A-II and tested immediately consumed significantly more water than the 1 h delay animals.	Water	78-83	angiotensinogen	Homo sapiens	22-26
20168760-7	1977	At 12.5-microm wavelength, water fog extinction is nearly independent of droplet size distribution, suggesting a simple scheme for measurement of total liquid water content of an optical path.	Water	27-32	zinc finger protein, FOG family member 1	Homo sapiens	33-36
20168760-7	1977	At 12.5-microm wavelength, water fog extinction is nearly independent of droplet size distribution, suggesting a simple scheme for measurement of total liquid water content of an optical path.	Water	159-164	zinc finger protein, FOG family member 1	Homo sapiens	33-36
870513-0	1977	The effects of ovine prolactin on water and electrolyte excretion in man are attributable to vasopressin contamination.	Water	34-39	prolactin	Homo sapiens	21-30
853038-0	1977	Regulation of phospholipase A2 activity by different lipid-water interfaces.	Water	59-64	phospholipase A2 group IB	Homo sapiens	14-30
853038-3	1977	The [DL-(3-13C)Ala8]phospholipase A2 could be resolved into the pure diastereoisomers, [D-(3-13C)Ala8]phospholipase A2 and [L-(3-13C)Ala8]phospholipase A2 by elution on Sephadex G-100 in the presence of a micellar lipid-water interface, as well as by conventional ion exchange chromatography on carboxymethylcellulose.	Water	220-225	phospholipase A2 group IB	Homo sapiens	20-36
885476-4	1977	Water loading diminished arginine vasopressin concentrations while dehydration increased it.	Water	0-5	arginine vasopressin	Homo sapiens	34-45
870513-0	1977	The effects of ovine prolactin on water and electrolyte excretion in man are attributable to vasopressin contamination.	Water	34-39	arginine vasopressin	Homo sapiens	93-104
870513-10	1977	Aqueous vasopressin, 50 mU (containing in 25 mg of ovine prolactin), produced a decrease in CH2O not significantly different from prolactin in 6 water loaded subjects.	Water	145-150	arginine vasopressin	Homo sapiens	8-19
896887-0	1977	Vasopressin administration in the first month of life: effects of growth and water metabolism in hypothalamic diabetes insipidus rats.	Water	77-82	arginine vasopressin	Rattus norvegicus	0-11
874867-6	1977	Plasma renin concentration (PRC) of water restricted sheep was 2-3 times normal.	Water	36-41	renin	Ovis aries	7-12
896887-7	1977	Six weeks following vasopressin treatment, homozygous, diabetes insipidus rats which had received vasopressin had increased 24 hr water intakes and decreased urine osmolalities compared to control, homozygous rats, Heterozygous rats also had decreased urine osmolalities resulting from vasopressin six weeks after the cessation of vasopressin treatment.	Water	130-135	arginine vasopressin	Rattus norvegicus	98-109
896887-7	1977	Six weeks following vasopressin treatment, homozygous, diabetes insipidus rats which had received vasopressin had increased 24 hr water intakes and decreased urine osmolalities compared to control, homozygous rats, Heterozygous rats also had decreased urine osmolalities resulting from vasopressin six weeks after the cessation of vasopressin treatment.	Water	130-135	arginine vasopressin	Rattus norvegicus	98-109
896887-7	1977	Six weeks following vasopressin treatment, homozygous, diabetes insipidus rats which had received vasopressin had increased 24 hr water intakes and decreased urine osmolalities compared to control, homozygous rats, Heterozygous rats also had decreased urine osmolalities resulting from vasopressin six weeks after the cessation of vasopressin treatment.	Water	130-135	arginine vasopressin	Rattus norvegicus	98-109
837423-3	1977	Light and electron microsopic examination of choroid plexuses from lateral ventricles of water-deprived and subcutaneously or intravenously vasopressin administered rats reveal morphologic changes typical for vasopressin responsive fluid transporting epithelia during hormonal stimulation.	Water	89-94	arginine vasopressin	Rattus norvegicus	209-220
557336-3	1977	Changes in the absorption spectra of glycerol-water mixtures of rhodopsin-egg phosphatidylcholine and rhodopsin-asolectin recombinants were monitored after the sample was cooled to -196 degrees C, presented with light of wavelength greater than 440 nm, and then warmed gradually to room temperature.	Water	46-51	rhodopsin	Homo sapiens	64-73
842694-0	1977	Prolactin and fetal osmoregulation: water transport across isolated human amnion.	Water	36-41	prolactin	Homo sapiens	0-9
842694-7	1977	The results imply an active role for prolactin on water transport across human amnion.	Water	50-55	prolactin	Homo sapiens	37-46
402387-0	1977	Relationship of aggregated intramembranous particles to water permeability in vasopressin-treated toad urinary bladder.	Water	56-61	arginine vasopressin	Homo sapiens	78-89
557420-0	1977	Studies on the conformation of beta-endorphin and its constituent fragments in water and trifluorethanol by CD spectroscopy.	Water	79-84	proopiomelanocortin	Homo sapiens	31-45
45571-0	1977	An intrarenal effect of somatostatin on water excretion.	Water	40-45	somatostatin	Canis lupus familiaris	24-36
45571-1	1977	Intrarenal infusion of somatostatin in anesthetized dogs produced a prompt increase in urine flow in association with a decrease in urinary osmolality and an increase in free water clearance.	Water	175-180	somatostatin	Canis lupus familiaris	23-35
838497-2	1977	They include the sensation of thirst, which stimulates water intake, the secretion of vasopressin, which helps prevent water loss, and the secretion of aldosterone, which helps prevent sodium depletion.	Water	119-124	arginine vasopressin	Homo sapiens	86-97
402387-6	1977	Since neither agent affects vasopressin-stimulated sodium movement, these findings indicate that the phenomenon of particle aggregation is specifically related to vasopressin-induced water permeability and not to changes in urea or sodium permeability.	Water	183-188	arginine vasopressin	Homo sapiens	163-174
402387-3	1977	We examined the effect of methohexital, a selective inhibitor of vasopressin-stimulated water flow, and the effect of phloretin, a selective inhibitor of urea permeability, on the structure of the granular cell luminal membrane.	Water	88-93	arginine vasopressin	Homo sapiens	65-76
402387-4	1977	Methohexital treatment of the vasopressin-stimulated toad bladder reduced both the osmotic water flow and vasopressin-induced alterations of membrane structure to the same extent.	Water	91-96	arginine vasopressin	Homo sapiens	30-41
848248-1	1977	The effect on serum gastrin levels of lysin-acetylsalicylate (LAS), water soluble derivative of acetylsalicylic acid, was investigated in mice.	Water	68-73	gastrin	Mus musculus	20-27
323791-2	1977	In the same time, iron is released from serum transferrin, reduced and determined at 535 mn by incubation in a water bath at 55 degrees for five minutes within a formate buffered system (pH 2,6; i = 0,05) including bathophenanthroline sulfonate.	Water	111-116	transferrin	Homo sapiens	46-57
319325-8	1977	In the disordered salt and water metabolism of the obese, persistently high AVP values during water loading appeared to be a factor in the delay of water excretion.	Water	27-32	arginine vasopressin	Homo sapiens	76-79
319325-8	1977	In the disordered salt and water metabolism of the obese, persistently high AVP values during water loading appeared to be a factor in the delay of water excretion.	Water	94-99	arginine vasopressin	Homo sapiens	76-79
190897-3	1977	The increases in osmotic water permeability caused by vasopressin or cyclic AMP were unaffected by a serosal potassium concentration of 21.5 mM.	Water	25-30	arginine vasopressin	Homo sapiens	54-65
920500-2	1977	Oxidation of partially thiolated insulin (0.5-0.7 SH group/mole), formed by reacting insulin with AHTL, with, (a) potassium ferricyanide, (b) Cu++-oxygen gave water soluble macromolecules containing 20-26 and 410-708 monomer units respectively which had rod-random coil shape (light scattering).	Water	159-164	insulin	Homo sapiens	33-40
401926-2	1977	An oral water load of 20 ml/kg had no effect on basal serum PRL or TSH levels but did result in an increased PRL response to methyl-TRH in the ten euthyroid patients.	Water	8-13	prolactin	Homo sapiens	109-112
899932-4	1977	Stimulation of endogenous PTH secretion by calcium-poor hyperoncotic albumin resulted in a similar decrease in net calcium, sodium, and water absorption.	Water	136-141	parathyroid hormone	Rattus norvegicus	26-29
899932-5	1977	It is suggested that PTH has a direct inhibitory effect on jejunal calcium, sodium, and water absorption.	Water	88-93	parathyroid hormone	Rattus norvegicus	21-24
830596-0	1977	The effect of gastric inhibitory polypeptide on human jejunal water and electrolyte transport.	Water	62-67	gastric inhibitory polypeptide	Homo sapiens	14-44
830596-3	1977	During GIP infusion, net water Na, K, and HCO3 absorption was significantly reduced and chloride flux was switched from absorption to secretion when compared to pre- and post-GIP control periods (p less than 0.001).	Water	25-30	gastric inhibitory polypeptide	Homo sapiens	7-10
830909-4	1977	Lung compliance was significantly lower in infants with increased PBF (4.9 ml/cm H2O) than in those with decreased PBF (8.9 ml/cm H2O) (P less than 0.01).	Water	81-84	PTTG1 interacting protein	Homo sapiens	66-69
836992-4	1977	3 The daily administration of 5 mg chlorpropamide combined with chlorothiazide in the drinking water (4 mg/1) to Pitressin-treated DI rats potentiated the response to small doses of vasopressin (25 and 50 mu Pitressin/24 hours).	Water	95-100	arginine vasopressin	Rattus norvegicus	182-193
187624-5	1977	In a control group, bolus injections of 200 muU of vasopressin caused a rise in urinary osmolality (Uosm) from 124 +/- 6 to 253 +/- 20 mosmol/kg H2O (P less than 0.005).	Water	145-148	arginine vasopressin	Rattus norvegicus	51-62
19284-0	1977	Regulation of phospholipase A2 activity by different lipid-water interfaces.	Water	59-64	phospholipase A2 group IB	Homo sapiens	14-30
187624-6	1977	In a group treated with 2 mg/kg of indomethacin the same dose of vasopressin caused a significantly greater (P less than 0.001) rise in Uosm from 124 +/- 7 to 428 +/- 19 mosmol/kg H2O.	Water	180-183	arginine vasopressin	Rattus norvegicus	65-76
895996-1	1977	Plasma prolactin was determined in a longitudinal study, where -9 manic-depressive patients were examined before lithium treatment and at various times during the treatment with the aim of unravelling a possible association between initial changes in water and sodium balance during lithium treatment and changes in plasma prolactin level.	Water	251-256	prolactin	Homo sapiens	7-16
189008-4	1977	The submaximal or maximal increase in osmotic water flow caused by vasopressin was inhibited by serosal carbamazepine concentrations as low as 0.01 mM.	Water	46-51	arginine vasopressin	Homo sapiens	67-78
999834-1	1976	When the isomerization of dihydroxyacetone phosphate to D-glyceraldehyde 3-phosphate is catalyzed by triosephosphate isomerase in tritiated water, both the substrate and product become labeled.	Water	140-145	triosephosphate isomerase 1	Homo sapiens	101-126
1034911-2	1976	Arginine vasopressin was infused into the V. portae and into the V. cava of unanesthetized rats in water diuresis.	Water	99-104	arginine vasopressin	Rattus norvegicus	9-20
1022520-9	1976	Substance P-like immunoreactivity was also demonstrated in hot-water extracts of porcine duodenum, jejunum, ileum, cecum, middle colon, rectum, pancreas, stomach and pituitary.	Water	63-68	tachykinin precursor 1	Homo sapiens	0-11
999835-1	1976	When the isomerization of D-glyceraldehyde 3-phosphate to dihydroxyacetone phosphate is catalyzed by triosephosphate isomerase in tritiated water, both the substrate and the product become labeled.	Water	140-145	triosephosphate isomerase 1	Homo sapiens	101-126
999837-0	1976	Energetics of triosephosphate isomerase: the nature of the proton transfer between the catalytic base and solvent water.	Water	114-119	triosephosphate isomerase 1	Homo sapiens	14-39
1070418-0	1976	The specificity of antisera for the radioimmunoassay of arginine-vasopressin in human plasma and urine during water loading and dehydration.	Water	110-115	arginine vasopressin	Homo sapiens	56-76
191849-2	1976	If the cannulae in the preoptice region were angled to bypass the lateral ventricles water intake elicited by ANG II was less and pretreating the cerebral ventricles with saralasin acetate did not reduce the drinking response.	Water	85-90	angiotensinogen	Homo sapiens	110-116
1031496-6	1976	Water loading suppressed the plasma AVP concentration.	Water	0-5	arginine vasopressin	Homo sapiens	36-39
1002353-6	1976	The vasopressin (DDAVP) refractory distorsion of the relationship between osmolal clearance and free water reabsorpton (induced by pseudo-antialdosterone agents and potentiated by antialdosterone drugs) observed in all the 6 cases of the present patient material favoured the "loop hypothesis".	Water	101-106	arginine vasopressin	Homo sapiens	4-15
1029908-1	1976	Water, saline and ethanol extracts of Eugenia caryophyllus inhibited brain acetylcholinesterase (AchE) activity.	Water	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-95
1029908-1	1976	Water, saline and ethanol extracts of Eugenia caryophyllus inhibited brain acetylcholinesterase (AchE) activity.	Water	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-101
11212-7	1976	Moreover, although the isoionic points of ferritin and apoferritin are identical in water, the isoionic point of ferritin is 0.5 pH unit lower than that of apoferritin in 0.16 to 1 M KCl.	Water	84-89	ferritin heavy chain	Equus caballus	55-66
187630-1	1976	A three-month study of the chemistry of the water erosion of two forms of ASPA cement has been made.	Water	44-49	aspartoacylase	Homo sapiens	74-78
1033127-0	1976	[Effect of mineral water on the secretion of insulin in an acute experiment].	Water	19-24	insulin	Homo sapiens	45-52
999879-6	1976	A bimodal distribution of the catalase, with additional heavy bands, was only observed in metrizamide gradients in light water, where rather high metrizamide concentrations are needed even for a banding of the uncomplexed enzyme.	Water	121-126	catalase	Homo sapiens	30-38
999881-0	1976	NMR relaxation investigation of water mobility in aqueous bovine serum albumin solutions.	Water	32-37	albumin	Homo sapiens	65-78
1034282-7	1976	AII also decreased the water permeability coefficient, Kf.	Water	23-28	angiotensinogen	Rattus norvegicus	0-3
1086619-7	1976	Application of tap water containing 2% NaCl led to a marked decrease in the amount of "classical" NSM but did only slightly impair the amount of CRF-granules.	Water	19-24	nuclear RNA export factor 1	Rattus norvegicus	15-18
184113-1	1976	Vasopressin increases the permeability of the total urinary bladder, an analogue of the mammalian renal collecting duct, to water and small solutes, especially the amide urea.	Water	124-129	arginine vasopressin	Homo sapiens	0-11
184113-2	1976	We have observed that three general anesthetic agents of clinical importance, the gases methoxyflurane and halothane and the ultrashortacting barbiturate methohexital, reversibly inhibit vasopressin-stimulated water flow, but do not depress permeability to urea, or the the lipophilic solute diphenylhydantoin.	Water	210-215	arginine vasopressin	Homo sapiens	187-198
184113-6	1976	We conclude that the majority of water and urea transport takes place via separate pathways across the rate-limiting luminal membrane of the bladder cell, and that separate vasopressin-responsive cellular pools of cyclic AMP appear to control permeability to water and to urea.	Water	259-264	arginine vasopressin	Homo sapiens	173-184
1067316-1	1976	The acid resistance of powdered human dentin increased linearly after pretreatments in 2.5, 25, 250, and 1,000 mM NaF in water.	Water	121-126	C-X-C motif chemokine ligand 8	Homo sapiens	114-117
821964-2	1976	The effect of TRH induced acute elevation of endogenous serum prolactin on renal water, sodium, potassium and total solute excretion was investigated during metabolic balance conditions and during escape form mineralocorticoid excess in 8 normal volunteers (6 males, 2 females)...	Water	81-86	prolactin	Homo sapiens	62-71
9138-5	1976	Evidence is adduced to support the view that this slowness is connected with the role of water in the interaction between O2-/O2 and ferri-ferrocytochrome c in the positively charged interaction site on cytochrome c in which water molecules are specifically involved in maintaining the local structure of cytochrome c and participate in the process of electron equivalent transfer.	Water	89-94	cytochrome c, somatic	Homo sapiens	144-156
9138-5	1976	Evidence is adduced to support the view that this slowness is connected with the role of water in the interaction between O2-/O2 and ferri-ferrocytochrome c in the positively charged interaction site on cytochrome c in which water molecules are specifically involved in maintaining the local structure of cytochrome c and participate in the process of electron equivalent transfer.	Water	89-94	cytochrome c, somatic	Homo sapiens	203-215
9138-5	1976	Evidence is adduced to support the view that this slowness is connected with the role of water in the interaction between O2-/O2 and ferri-ferrocytochrome c in the positively charged interaction site on cytochrome c in which water molecules are specifically involved in maintaining the local structure of cytochrome c and participate in the process of electron equivalent transfer.	Water	225-230	cytochrome c, somatic	Homo sapiens	144-156
9138-5	1976	Evidence is adduced to support the view that this slowness is connected with the role of water in the interaction between O2-/O2 and ferri-ferrocytochrome c in the positively charged interaction site on cytochrome c in which water molecules are specifically involved in maintaining the local structure of cytochrome c and participate in the process of electron equivalent transfer.	Water	225-230	cytochrome c, somatic	Homo sapiens	203-215
950088-1	1976	Previous studies have shown that synthetic salmon calcitonin (SCT) infused intravenously causes secretion of water and electrolytes in the jejunum of normal human subjects.	Water	109-114	calcitonin related polypeptide alpha	Homo sapiens	50-60
1006242-12	1976	The most important mechanisms are either disturbed NaCL transport in the ascending limb of Henle"s loop, or antidiuretic hormone (ADH) dependent or ADH independent decrease in water permeability of the enddistal convolutions and collecting ducts, or osmotic diuresis.	Water	176-181	arginine vasopressin	Homo sapiens	108-128
1006242-12	1976	The most important mechanisms are either disturbed NaCL transport in the ascending limb of Henle"s loop, or antidiuretic hormone (ADH) dependent or ADH independent decrease in water permeability of the enddistal convolutions and collecting ducts, or osmotic diuresis.	Water	176-181	arginine vasopressin	Homo sapiens	130-133
1006242-12	1976	The most important mechanisms are either disturbed NaCL transport in the ascending limb of Henle"s loop, or antidiuretic hormone (ADH) dependent or ADH independent decrease in water permeability of the enddistal convolutions and collecting ducts, or osmotic diuresis.	Water	176-181	arginine vasopressin	Homo sapiens	148-151
8133-3	1976	Rats in which hepatic histidine ammonia-lyase activity was either depressed by DL-hydrazinoimidazolylproprionic acid injection or elevated by feeding a high protein diet displayed proportionately altered rates of 3H2O release into plasma water following L-[3-3H] histidine administration.	Water	238-243	histidine ammonia lyase	Rattus norvegicus	22-45
223029-1	1976	The rate of water proton relaxation of the solutions of human serum albumin (HSA) modified by different spin labels has been investigated by spin echo technique.	Water	12-17	albumin	Homo sapiens	62-75
956768-0	1976	Nature of the water permeability increase induced by antidiuretic hormone (ADH) in toad urinary bladder and related tissues.	Water	14-19	arginine vasopressin	Homo sapiens	53-73
952970-2	1976	It was found: (1) In the presence of benzyl viologen as electron acceptor and with water as natural electron donor trypsin, incubation leads to a complete suppression of the absorption changes of the electrochromic effect and of chlorophyll aI and chlorophyll aII.	Water	83-88	NLR family pyrin domain containing 3	Homo sapiens	260-263
17841821-4	1976	The water content of a population of these beetles increased by 13.9 percent during one fog.	Water	4-9	zinc finger protein, FOG family member 1	Homo sapiens	88-91
956768-0	1976	Nature of the water permeability increase induced by antidiuretic hormone (ADH) in toad urinary bladder and related tissues.	Water	14-19	arginine vasopressin	Homo sapiens	75-78
956768-3	1976	Applying this criterion to the toad urinary bladder, we find that even in the unstimulated bladder, water probably crosses the luminal membrane primarily through small aqueous pores, and that this almost certainly the case after antidiuretic hormone (ADH) stimulation.	Water	100-105	arginine vasopressin	Homo sapiens	251-254
932018-3	1976	Sound velocities and heat capacities have also been measured for various concentrations of lysozyme-water solutions at 25 degrees.	Water	100-105	lysozyme	Homo sapiens	91-99
983544-7	1976	35 mg NO3-/1 drinking water causes a doubling of the basic intake values, 70 mg NO3-/1 its triplication.	Water	22-27	NBL1, DAN family BMP antagonist	Homo sapiens	6-9
983544-7	1976	35 mg NO3-/1 drinking water causes a doubling of the basic intake values, 70 mg NO3-/1 its triplication.	Water	22-27	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
939234-4	1976	Our study suggests that there exists a feedback between the renin-angiotensin-aldosterone system and ADH release and that this feedback plays an important role in the regulation of water and electrolyte balance in the young infant.	Water	181-186	renin	Homo sapiens	60-65
932018-6	1976	The number of water molecules hydrated to 1 mol of lysozyme was estimated from the volume and compressibility and found to be 162 at 25 degrees.	Water	14-19	lysozyme	Homo sapiens	51-59
180815-2	1976	Infusion of ovine prolactin (200 nmol/kg per h) ablated C(H2O) in HHDI rats but had no effect on T(cH2O) in hydropenic rats.	Water	58-61	prolactin	Rattus norvegicus	18-27
947939-4	1976	These results suggest that norepinephrine-induced water diuresis is related to the suppression of the vasopressin release.	Water	50-55	arginine vasopressin	Homo sapiens	102-113
978878-0	1976	[Interstitial cells of the medulla and the renin-angiotensin system in disorders of water-salt homeostasis].	Water	84-89	renin	Homo sapiens	43-48
180815-1	1976	The effect of prolactin on free water clearance (C(H2O)) and reabsorption (T(cH2O)) was assessed in hereditary hypothalamic diabetes insipidus (HHDI) and hydropenic Sprague-Dawley rats.	Water	32-37	prolactin	Rattus norvegicus	14-23
996041-3	1976	Intracranial injection of 10 mug Ang II through cannulas implanted in the anterior diencephalon caused a significant increase in water intake.	Water	129-134	ribonuclease A family member k6	Gallus gallus	33-36
1064879-1	1976	A peptide corresponding to the 11 amino acid residues of the NH2-terminal portion in the sequence of carcinoembryonic antigen(CNTHETIC CEA(1-11) peptide was attached by means of a water-soluble carbodiimide reagent to multichain poly(DL-alanine( as well as to bovine serum albumin.	Water	180-185	CEA cell adhesion molecule 3	Homo sapiens	135-138
179794-0	1976	Water-soluble specific growth hormone binding sites from cultured human lymphocytes: preparation and partial characterization.	Water	0-5	growth hormone 1	Homo sapiens	23-37
8041-3	1976	Chronic administration of glucose or nicotinamide in drinking water inhibits the activity of rat liver tryptophan pyrrolase, and subsequent withdrawal causes an enhancement.	Water	62-67	tryptophan 2,3-dioxygenase	Rattus norvegicus	103-123
1276900-1	1976	(1) The possibility that water intake elicited by the administration of angiotensin-II to the preoptic region (POA), subfornical organ and anterior third ventricle is mediated by separate neural systems was investigated in 58 male Wistar rats using electrolytic lesion techniques.	Water	25-30	angiotensinogen	Rattus norvegicus	72-86
1276900-2	1976	(2) Lesions of the midlateral hypothalamus and paramedial rostral midbrain produced a significant reduction in water intake to angiotensin-II microinjected into the POA but did not affect drinking following administration of angiotensin-II to the subfornical organ or anterior third ventricle.	Water	111-116	angiotensinogen	Rattus norvegicus	127-141
1276900-5	1976	(5) It is concluded that separate neural systems mediate water intake elicited by administration of angiotensin-II to the preoptic area, subfornical organ and anterior third ventricle.	Water	57-62	angiotensinogen	Rattus norvegicus	100-114
1276900-7	1976	(6) The present results are in agreement with previous work which indicates that water intake induced by central administration of angiotensin-II, carbachol and hypertonic saline is subserved by different neural substrates.	Water	81-86	angiotensinogen	Rattus norvegicus	131-145
943790-4	1976	These results suggest that the alteration of the normal corticosteroid rhythm and/or changes in prolactin secretion may account, in part at least, for the changes noted in cycle length after restricting the water intake.	Water	207-212	prolactin	Rattus norvegicus	96-105
57235-9	1976	The vasopressin-induced increase in diffusional water flow was similarly reduced.	Water	48-53	arginine vasopressin	Homo sapiens	4-15
57235-13	1976	The Ktrans (permeability coefficient) of ethanol and water is increased by vasopressin.	Water	53-58	arginine vasopressin	Homo sapiens	75-86
1255068-0	1976	Proceedings: Evidence that the salt- and water-retaining actions of angiotensin II upon the kidney in vivo are not affected by the protein synthesis inhibitor cycloheximide.	Water	41-46	angiotensinogen	Homo sapiens	68-82
1255073-0	1976	Proceedings: Water and sodium accumulation in rabbits after administration of prolactin.	Water	13-18	prolactin	Oryctolagus cuniculus	78-87
1252433-8	1976	The latter water-soluble polypeptides remained associated in discrete complexes which retained the capacity to bind glyceraldehyde-3-phosphate dehydrogenase.	Water	11-16	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	116-156
6974-3	1976	There was a significant correlation between the volume of water intake and plasma angiotensin II levels following the injection of polyethylene glycol but not following isoproterenol.	Water	58-63	angiotensinogen	Rattus norvegicus	82-96
176921-0	1976	Mass transport across cell membranes: the effects of antidiuretic hormone on water and solute flows in epithelia.	Water	77-82	arginine vasopressin	Homo sapiens	53-73
1269623-0	1976	Host immune rejection of TA3 ascites carcinoma cells following administration of a water soluble carbodiimide.	Water	83-88	RIKEN cDNA 2700049A03 gene	Mus musculus	25-28
3203-6	1976	Addition of salts to an alkaline solution of cytochrome c 552 in water results in the formation of a 600-nm high-spin band with a concomitant quenching of tryptophan fluorescence.	Water	65-70	cytochrome c, somatic	Homo sapiens	45-57
811985-5	1976	When water deprivation was coupled with vasopressin administration, the maximum urinary concentration observed was 384 mOsm per kilogram of water.	Water	5-10	arginine vasopressin	Homo sapiens	40-51
811985-5	1976	When water deprivation was coupled with vasopressin administration, the maximum urinary concentration observed was 384 mOsm per kilogram of water.	Water	140-145	arginine vasopressin	Homo sapiens	40-51
7705-1	1976	Vasopressin is known to increase the permeability of the toad bladder, an analogue of the mammalian collecting duct, to water and hydrophilic solutes such as urea.	Water	120-125	arginine vasopressin	Homo sapiens	0-11
990906-5	1976	Chocolate milk is consumed but tap water is actively rejected.	Water	35-40	nuclear RNA export factor 1	Rattus norvegicus	31-34
990906-7	1976	The results support the conclusion that rats with LH lesions require an arousing stimulus for feeding but that the same externally applied arousing stimulus enhances active rejection of tap water.	Water	190-195	nuclear RNA export factor 1	Rattus norvegicus	186-189
187379-3	1976	Sodium and water permeability effects of vasopressin have been shown in toad bladder to have different dose response characteristics.	Water	11-16	arginine vasopressin	Rattus norvegicus	41-52
187379-5	1976	Maximum water transport occurs at a higher dose of vasopressin (100 mU/ml) over a concentration range associated with hormone-stimulated adenylate cyclase activity.	Water	8-13	arginine vasopressin	Rattus norvegicus	51-62
187379-6	1976	The water transport response to low doses of vasopressin may be potentiated by aldosterone treatment, an effect that can be related to the inhibition of tissue phosphodiesterase activity and subsequent increased cyclic AMP concentrations.	Water	4-9	arginine vasopressin	Rattus norvegicus	45-56
187379-7	1976	In steroid depleted conditions the cyclic AMP medicate efflux of mitochondrial calcium ions, that occurs at low doses of vasopressin, may prevent the release of membrane bound calcium ions and thus inhibit the water permeability effect of the hormone.	Water	210-215	arginine vasopressin	Rattus norvegicus	121-132
1036731-1	1976	The possible role of endogenous prolactin (hPRL) in the regulation of renal water, Na and K excretion during sleep was tested in a group of 10 healthy female volunteers.	Water	76-81	prolactin	Homo sapiens	32-41
1036731-1	1976	The possible role of endogenous prolactin (hPRL) in the regulation of renal water, Na and K excretion during sleep was tested in a group of 10 healthy female volunteers.	Water	76-81	prolactin	Homo sapiens	43-47
1107423-7	1976	Incubation of G-100 fractions containing MIF with water insoluble chymotrypsin destroyed the activity of MIF, indicating its protein nature.	Water	50-55	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	41-44
1107423-7	1976	Incubation of G-100 fractions containing MIF with water insoluble chymotrypsin destroyed the activity of MIF, indicating its protein nature.	Water	50-55	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	105-108
1276228-1	1976	Anionic micelles of sodium lauryl sulfate, NaLS, catalyze the monoalkylation of Hg2+ in dilute acid by alkyl aquobis-(dimethyl glyoximato) cobalt (III), RCo(DH)2(H2O) degrees and the related propane derivatives RCo(DOH) DOpn (H2O)+, where R = Me, Et, n-C5H11.	Water	162-165	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	147-150
1276228-1	1976	Anionic micelles of sodium lauryl sulfate, NaLS, catalyze the monoalkylation of Hg2+ in dilute acid by alkyl aquobis-(dimethyl glyoximato) cobalt (III), RCo(DH)2(H2O) degrees and the related propane derivatives RCo(DOH) DOpn (H2O)+, where R = Me, Et, n-C5H11.	Water	226-229	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	147-150
1254417-4	1976	The portal pressure rose from a mean of 10.4 cm H2O to a mean of 21.2 cm H2O after bradykinin injection.	Water	73-76	kininogen 1	Canis lupus familiaris	83-93
1630-1	1976	In healthy male subjects aldosterone excretion and plasma renin activity were reduced by a 4-6 hr head-out immersion in thermoindifferent water baths (35.5 +/- 0.1 degrees C).	Water	138-143	renin	Homo sapiens	58-63
7705-6	1976	We would conclude from these studies that the effect of vasopressin on the luminal cell membrane is a widespread one, modifying both lipid components and components involved in amide, sodium and water transport.	Water	195-200	arginine vasopressin	Homo sapiens	56-67
139628-4	1976	In this group, vasopressin lowered the TF/P Na+ ratio and raised the TF/P K+ ratio in the initial part of the distal tubules of the superficial nephrons, but raised water absorption only beyond the initial part of the distal tubules.	Water	165-170	arginine vasopressin	Rattus norvegicus	15-26
1013169-7	1976	Results demonstrate that angiotensin II decreased lever pressing and increased schedule induced water consumption without a concomitant increase in licking.	Water	96-101	angiotensinogen	Homo sapiens	25-39
1013169-9	1976	Under these conditions angiotensin II increased water consumption.	Water	48-53	angiotensinogen	Homo sapiens	23-37
139628-5	1976	Vasopressin reduced the urine flow by 72% in 30-day-old rats by raising water reabsorption beyond the initial part of the distal tubules.	Water	72-77	arginine vasopressin	Rattus norvegicus	0-11
1029018-5	1976	The relative selectivities for water by the ion exchanger, based on an integrated Kipling parameter, are Zn2+-form (reference) --1.00, Mg2+ --0.43, La3+ --0.38, Li+ +0.17, NMe4+ 0.20, NH4+ 0.31, NBU4+ 0.33, and H+ 0.68, the polyvalent counterions preferring DMSO.	Water	31-36	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	172-176
1215957-5	1975	In both sexes a significant correlation between AVP excretion and either plasma osmolality or free-water clearance was found.	Water	99-104	arginine vasopressin	Homo sapiens	48-51
1019160-4	1976	It was shown that intraventricular renin increased water intake, blood pressure and ADH secretion and that these effects were blocked by saralasin.	Water	51-56	renin	Homo sapiens	35-40
53-2	1975	The localization of the previously postulated interface recognition site (IRS) in porcine pancreatic phospholipase A2, required for a specific interaction between the enzyme and organized lipid-water interfaces, was investigated by ultraviolet difference spectroscopy, by measurements of the intrinsic fluorescence of the unique Trp residue, and by protection experiments against specific tryptic hydrolysis.	Water	194-199	phospholipase A2 group IB	Homo sapiens	101-117
5828-5	1976	Changing the solvent from water to D2O or by quenching experiments in presence of azide ions it could be shown that the desactivation of lysozyme is caused exclusively by singlet oxygen.	Water	26-31	lysozyme	Homo sapiens	137-145
1185597-4	1975	The highest average dose of morphine HCl consumed in tap water was 30 mg/kg within an hour session.	Water	57-62	nuclear RNA export factor 1	Rattus norvegicus	53-56
241510-2	1975	The method consists of gradually oxygenating a blood sample by adding H2O2 in the presence of catalase (EC 1.11.1.6), to produce the reaction H2O2 leads to H2O + 1/2 O2.	Water	70-73	catalase	Homo sapiens	94-102
172153-1	1975	Osmotic water movement across the toad urinary bladder in response to both vasopressin and cyclic AMP was inhibited by 10(-5) to 10(-4) M colchicine on the serosal but not on the mucosal side.	Water	8-13	arginine vasopressin	Homo sapiens	75-86
1081883-2	1975	As a result of this extraction of rhodopsin with anion detergent (sodium cholate) in the concentrations not exceeding the critical concentration of micelloformation increases, and spontaneous release of rhodopsin into water phase is observed.	Water	218-223	rhodopsin	Homo sapiens	34-43
1081883-2	1975	As a result of this extraction of rhodopsin with anion detergent (sodium cholate) in the concentrations not exceeding the critical concentration of micelloformation increases, and spontaneous release of rhodopsin into water phase is observed.	Water	218-223	rhodopsin	Homo sapiens	203-212
765686-3	1975	Treatment of the dry biomass with boiling water gives a higher yield of ATP from the cells of eukaryote and prokaryote microorganisms as compared with other techniques, and permits to register the amount of APT at the moment of experiment.	Water	42-47	LYPLA2 pseudogene 1	Homo sapiens	207-210
1202199-11	1975	From NO3 sea water the extra influx of 204Tl assoicated with nerve impulses was about the same as 42K.	Water	13-18	NBL1, DAN family BMP antagonist	Homo sapiens	5-8
1195561-1	1975	The antidiuretic action of a number of vasopressin analogues has been measured in the rat and man in water diuresis.	Water	101-106	arginine vasopressin	Rattus norvegicus	39-50
172580-2	1975	Vasopressin increased the scc across the toad bladder (the natriferic response), but this stimulation was considerably reduced in the presence of a hypo-osmotic solution on the mucosal side, conditions under which water transfer across the membrane was also increased.	Water	214-219	arginine vasopressin	Homo sapiens	0-11
170980-6	1975	The properties of catalase are altered in phosphate and in distilled water.	Water	69-74	catalase	Homo sapiens	18-26
240438-0	1975	Hydrogen ion titration of lysozyme in alcohol-water solutions.	Water	46-51	lysozyme	Homo sapiens	26-34
808606-2	1975	Effects on vasopressin-stimulated water loss from isolated toad bladder.	Water	34-39	arginine vasopressin	Rattus norvegicus	11-22
808606-4	1975	These compounds were shown to inhibit both the oxytocin-induced smooth muscle contraction in the isolated rat uterus and the vasopressin-induced water loss from the isolated toad bladder.	Water	145-150	arginine vasopressin	Rattus norvegicus	125-136
1149403-10	1975	The release of prostaglandins from the kidney by bradykinin amplifies the renal vasodilator action of the kinin and possibly mediates its effect on excretion of solute-free water.	Water	173-178	kininogen 1	Canis lupus familiaris	49-59
1225704-3	1975	The offspring from the mothers receiving lead acetate during lactation demonstrated a greater aversion to the lead acetate solution than did the offspring from mothers receiving tap water.	Water	182-187	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	178-181
169890-7	1975	In similar experiments with ferric myoglobin, the addition of cyanide caused a large decrease in the enhancement of the proton relaxation rate of both formate and water, indicating the displacement of water and formate from the heme and the vicinity of the heme, respectively.	Water	163-168	myoglobin	Equus caballus	35-44
168231-9	1975	These results were obtained despite the fact that all four concentrations of PGE1 tested were found capable of inhibiting ADH-induced water flow under appropriate conditions or, in other words, were inhibiting the adenylate cyclase controlling water flow, Thus the increase in cyclic AMP content in response to PGE1 is not derived from this enzyme.	Water	134-139	arginine vasopressin	Homo sapiens	122-125
168231-15	1975	With high concentrations of PGE1 in the presence of theophylline or high concentrations of ADH, the adenylate cyclase responsible for water flow is inhibited; However, PGE1 can stimulate a tissue adenylate cyclase to sufficiently high levels that cyclic AMP spills over into the "water flow compartment" and thus stimulates water flow.	Water	134-139	arginine vasopressin	Homo sapiens	91-94
168231-15	1975	With high concentrations of PGE1 in the presence of theophylline or high concentrations of ADH, the adenylate cyclase responsible for water flow is inhibited; However, PGE1 can stimulate a tissue adenylate cyclase to sufficiently high levels that cyclic AMP spills over into the "water flow compartment" and thus stimulates water flow.	Water	280-285	arginine vasopressin	Homo sapiens	91-94
168231-15	1975	With high concentrations of PGE1 in the presence of theophylline or high concentrations of ADH, the adenylate cyclase responsible for water flow is inhibited; However, PGE1 can stimulate a tissue adenylate cyclase to sufficiently high levels that cyclic AMP spills over into the "water flow compartment" and thus stimulates water flow.	Water	280-285	arginine vasopressin	Homo sapiens	91-94
1150880-7	1975	The Uosm increased from 93 +/- 9 to 244 +/- 33 mosmol/kg H2O (P less than 0.001) after the first dose of vasopressin, but after the second dose of vasopressin the Uosm increased to a significantly greater degree from 106 +/- 14 to 702 +/- 69 mosmol/kg H2O (P less than 0.001).	Water	252-255	arginine vasopressin	Homo sapiens	147-158
1171984-4	1975	From 2, [3-thienylalanine]-8-lysine-vasopressin was obtained by removing the Boc-protecting groups with trifluoroacetic acid and ethylcarbamoyl (Ec) protecting groups in refluxing liquid NH3 followed by oxidative cyclization in H2O-MeOH using ICH2CH2I.	Water	228-231	arginine vasopressin	Rattus norvegicus	36-47
1159050-2	1975	In 10 normal men there was a small but statistically significant rise in mean prolactin, from 7.6 to 12.3 ng/ml, occurring within half an hour after the ingestion of a water load of 20 ml/kg.	Water	168-173	prolactin	Homo sapiens	78-87
807853-0	1975	PCB concentrations in North Atlantic surface water.	Water	45-50	pyruvate carboxylase	Homo sapiens	0-3
809840-2	1975	This alteration consists of an ordered aggression of intramembranous particles, and appears to be of functional significance, since the frequency of aggregation sites per area of membrane is closely correlated with vasopressin-induced osmotic water flow.	Water	243-248	arginine vasopressin	Homo sapiens	215-226
173287-12	1975	Preincubation of synaptic membranes in the water or buffer increased the net activity of phospholipase A2.	Water	43-48	phospholipase A2 group IB	Homo sapiens	89-105
1152298-1	1975	Kidney extract from rats which were adrenalectomized and given tap water was dialyzed, salted out, ultrafiltrated or heated.	Water	67-72	nuclear RNA export factor 1	Rattus norvegicus	63-66
1171026-1	1975	Previous observations by other workers indicating suppression of serum prolactin (hPRL) by water loading could not be confirmed.	Water	91-96	prolactin	Homo sapiens	71-80
1171026-1	1975	Previous observations by other workers indicating suppression of serum prolactin (hPRL) by water loading could not be confirmed.	Water	91-96	prolactin	Homo sapiens	82-86
1171026-3	1975	It was of interest that the acute ingestion of water resulted in a triphasic response in serum hPRL levels.	Water	47-52	prolactin	Homo sapiens	95-99
1132669-0	1975	The effect of prolactin on water movement through the isolated amniotic membrane of the guinea pig.	Water	27-32	prolactin	Cavia porcellus	14-23
1120786-2	1975	In studies on six water-loaded normal subjects in a steady state of water diuresis, insulin was administered i.v.	Water	18-23	insulin	Homo sapiens	84-91
1190814-2	1975	The renin aldosterone system was suppressed in this child and it was suggested that this may be a factor in the development of hypernatraemia when abnormal water losses occur in infants fed on hyperosmolar feeds.	Water	156-161	renin	Homo sapiens	4-9
1168128-7	1975	Growth hormone and human placental lactogen appear  to affect jejunal water and electrolyte transport in the same manner as occurs with prolactin, possibly by influencing active ion transport.	Water	70-75	growth hormone 1	Homo sapiens	0-14
1168128-7	1975	Growth hormone and human placental lactogen appear  to affect jejunal water and electrolyte transport in the same manner as occurs with prolactin, possibly by influencing active ion transport.	Water	70-75	chorionic somatomammotropin hormone 2	Homo sapiens	25-43
49892-10	1975	It is supposed that the principal factors causing activation of the renin-angiotensin system in thyrotoxicosis were the loss of water and electrolytes by the organism and the appearance of oversensitivity to adrenergic receptors.	Water	128-133	renin	Homo sapiens	68-73
167373-2	1975	Unilateral nephrectomy and water deprivation increased serum prolactin levels significantly.	Water	27-32	prolactin	Rattus norvegicus	61-70
164901-2	1975	Water relaxation studies at 8, 24, 100, and 220 MHz indicate two classes of bound Co(II).	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	Water	252-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	Water	252-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
164901-10	1975	The role of the catalytic Co(II) thus appears to be the activation of a hydroxyl or water ligand which polarizes the aldehyde carbonyl group by hydrogen bonding.	Water	84-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
167373-6	1975	These observations suggest that PRL has a role in salt and water metabolism and that PRL receptors in the kidney and adrenals participate in this regulatory system.	Water	59-64	prolactin	Rattus norvegicus	32-35
163889-1	1975	It is well established that active sodium-ion transport and water flow across isolated toad bladder are increased by antidiuretic hormone (ADH) and by cAMP.	Water	60-65	arginine vasopressin	Homo sapiens	117-143
163596-6	1975	Finally, it is demonstrated that 10 mM NaF increase the amount of cyclic AMP in the epithelial cells and in the solution bathing the bladder, but block the effect of vasopressin on water permeability, presumably at a step subsequent to the formation of cyclic AMP.	Water	181-186	arginine vasopressin	Homo sapiens	166-177
235667-2	1975	Both these results suggest the existence of a direct relationship between the salt regulating renin-angiotensin-aldosterone system and the water controlling AVP system.	Water	139-144	arginine vasopressin	Homo sapiens	157-160
1095802-0	1975	[Once more about the role of antidiuretic hormone in disorders of water-electrolyte metabolism in cardiac insufficiency].	Water	66-71	arginine vasopressin	Homo sapiens	29-49
1142603-0	1975	[Participation of antidiuretic hormone in the regulation of water-electrolyte metabolism in cardiac insufficiency].	Water	60-65	arginine vasopressin	Homo sapiens	18-38
1139445-3	1975	While holding-still, metabolic heat production (Hm,kcal-min--1) was inversely related to water temperature (Tw, degrees C) according to the equation Hm equals 4.19 minus-0.117 Tw.	Water	89-94	CD59 molecule (CD59 blood group)	Homo sapiens	56-62
236294-4	1975	In distilled water, the fibrinogen-stearyltrimethylammonium complex (FG-STA(Cl)) remained soluble in the presence of thrombin [ED 3.4.21.5] although the same peptides were released as those released from fibrinogen.	Water	13-18	fibrinogen beta chain	Homo sapiens	24-34
47826-5	1975	A NAS strain of PIV-3 dialyzed against distilled water showed an increased initial neuraminidase activity as compared to virus dialyzed against isotonic NaCL or to non-dialyzed virus.	Water	49-54	neuraminidase 1	Bos taurus	83-96
1168064-5	1975	However, with a large excess of hexokinase, the rate of the Pi leads to HOH exchange is further depressed.	Water	72-75	hexokinase 1	Homo sapiens	32-42
1233863-1	1975	The effect on water metabolism of 1-deamino-8-D-arginine vasopressin and lysine vasopressin have been studied and compared in 20 vasopressin-sensitive and 2 ADH-resistant diabetes insipidus patients.	Water	14-19	arginine vasopressin	Homo sapiens	57-68
180760-1	1975	Male albino rats were deprived of water for 6 days, then they were allowed to drink tap water ad libitim.	Water	88-93	nuclear RNA export factor 1	Rattus norvegicus	84-87
235497-3	1975	The association constants of ACTH (I-24) and (Pmp9)-ACTH (I-24) with the water-soluble acceptor paraquat, were nearly equal.	Water	73-78	proopiomelanocortin	Homo sapiens	29-33
235497-3	1975	The association constants of ACTH (I-24) and (Pmp9)-ACTH (I-24) with the water-soluble acceptor paraquat, were nearly equal.	Water	73-78	proopiomelanocortin	Homo sapiens	52-56
1127864-6	1975	After administration of exogenous vasopressin, V fell to 311 plus or minus 157 mul/min/kg or 5.2 plus or minus se 3.8% of the filtered load of water and U/Posm rose from 0.658 plus or minus se 0.043 to 2.124 plus or minus 0.454.	Water	143-148	arginine vasopressin	Rattus norvegicus	34-45
167172-2	1975	The permeability of lipophilic molecules was roughly proportional to bulk phase oil/water partition coefficients both in the presence and absence of hormone; i.e., ADH elicited a general nonselective increase in the permeation of all nine solutes tested.	Water	84-89	arginine vasopressin	Homo sapiens	164-167
176362-2	1975	Urea and water transport across the toad bladder epithelial cell  appears to take place through independent vasopressin-stimulated pathways.	Water	9-14	arginine vasopressin	Homo sapiens	108-119
124524-0	1975	[The water supply of SPF animal houses.	Water	5-10	SEC14 like lipid binding 2	Homo sapiens	21-24
170548-1	1975	This paper reviews the physiology of antidiuretic hormone, including the factors involving the formation, storage and release of the hormone, the metabolism of vasopressin and its physiologic and pharmacologic effects on water and electrolyte transport.	Water	221-226	arginine vasopressin	Homo sapiens	37-57
170549-3	1975	A ROLE OF VASOPRESSIN IS IMPLICATED SINCE NEITHER MAN NOR DOG WITHOUT A PITUITARY SOURCE OF VASOPRESSIN DEMONSTRATE THE SAME EFFECT OF CATECHOLAMINES ON WATER EXCRETION AS OBSERVED IN INTACT MAN AND DOG.	Water	153-158	arginine vasopressin	Homo sapiens	10-21
1143633-3	1975	Before 2% NaCl was substituted for the drinking water, vasopressin treatment significantly decreased food and water intake (p smaller than 0.05) and daily weight gain (p smaller than 0.01), but no significant effect on plasma osmolality or on neurohypophysial content of vasopressin and oxytocin could be demonstrated.	Water	48-53	arginine vasopressin	Rattus norvegicus	55-66
1143633-3	1975	Before 2% NaCl was substituted for the drinking water, vasopressin treatment significantly decreased food and water intake (p smaller than 0.05) and daily weight gain (p smaller than 0.01), but no significant effect on plasma osmolality or on neurohypophysial content of vasopressin and oxytocin could be demonstrated.	Water	110-115	arginine vasopressin	Rattus norvegicus	55-66
809721-6	1975	A relationship was found in rats between the amount of TRH ingested in drinking water and plasma levels of PRL and TSH; hormonal stores in the adenohypophysis usually declined.	Water	80-85	prolactin	Rattus norvegicus	107-110
1223917-1	1975	Release and binding of aspartate aminotransferase, malate dehydrogenase and protein from and to water-shocked vesicles obtained from rat liver mitochondria was shown to occur.	Water	96-101	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	23-49
237374-0	1975	[The water supply of SPF animal houses.	Water	5-10	SEC14 like lipid binding 2	Homo sapiens	21-24
4375541-0	1974	Effect of ablation of the subfornical organ on water intake elicited by systemically administered angiotensin-II.	Water	47-52	angiotensinogen	Homo sapiens	98-112
4464859-9	1974	The solubility of native insulin in aqueous polyethylene glycol and in water showed a pH-dependence similar to that observed for the distribution in the dextran-polyethylene glycol system.	Water	71-76	insulin	Homo sapiens	25-32
4474005-0	1974	The activity of phospholipase A2 in reversed micelles of phosphatidylcholine in diethyl ether: effect of water and cations.	Water	105-110	phospholipase A2 group IB	Homo sapiens	16-32
32189809-0	1974	Solubility of beta-Ca3(PO4)2 in the System Ca(OH)2-H3PO4-H2O at 5, 15, 25, and 37  C. Solubility isotherms of beta-tricalcium phosphate, beta-Ca(PO4)2, prepared by heating mixtures of CaCO3 and CaHPO4 above 800  C, were determined in the ternary system Ca(OH)2-H3PO4-H2O at 5, 15, 25, and 37  C in the pH range 6.0-7.5 by equilibration with dilute H3PO4 solutions.	Water	57-60	small nucleolar RNA, H/ACA box 3A	Homo sapiens	14-22
4464859-10	1974	Iodination of insulin decreased the solubility of the hormone in polyethylene glycol and in water in parallel, and decreased the pH value at which solubility was a minimum.	Water	92-97	insulin	Homo sapiens	14-21
4426701-6	1974	This four- to fivefold increase in nucleotide loss was evident at 4, 25, and 37 C. The permeability of 1-day-old immature spherules and 8-day-old endospores was considerably altered by lysozyme treatment of cells suspended in distilled water.	Water	236-241	lysozyme	Homo sapiens	185-193
4426701-5	1974	Mature endosporulating spherules removed from growth medium and resuspended in a solution of human or HEW lysozyme at 18 mug/ml in distilled water prompted leakage of four to five times as much of materials absorbing maximally at 260 nm into the supernatant as untreated control spherules during 90 min of incubation.	Water	141-146	lysozyme	Homo sapiens	106-114
4412581-0	1974	Conditioned flavor aversions to familiar tap water in rats: an adjustment with implications for aversion therapy treatment of alcoholism and obesity.	Water	45-50	nuclear RNA export factor 1	Rattus norvegicus	41-44
4369860-0	1974	Chlorophyll a and cytochrome c at a heptane-water interface.	Water	44-49	cytochrome c, somatic	Homo sapiens	18-30
4430400-0	1974	The effects of prolactin on the renal excretion of water, sodium, potassium and calcium in the rabbit.	Water	51-56	prolactin	Oryctolagus cuniculus	15-24
4452181-0	1974	[Syndrome of inadequate secretion of the antidiuretic hormone in a toxic reaction and elimination of water load following administration of vincristine sulfate].	Water	101-106	arginine vasopressin	Homo sapiens	41-61
4209873-0	1974	Effects of vasopressin on toad bladder membrane proteins: relationship to transport of sodium and water.	Water	98-103	arginine vasopressin	Homo sapiens	11-22
4857566-0	1974	Effect of pH on the kinetic and spectral properties of Crotalus adamanteu phospholipase A2 in H2O and D2O.	Water	94-97	phospholipase A2 group IB	Homo sapiens	74-90
4819758-0	1974	Zymogen-catalyzed hydrolysis of monomeric substrates and the presence of a recognition site for lipid-water interfaces in phospholipase A2.	Water	102-107	phospholipase A2 group IB	Homo sapiens	122-138
4724931-2	1973	Mean serum prolactin fell to 10.5 percent of baseline after oral water loading and to 15 percent of baseline after intravenous hypotonic saline infusion.	Water	65-70	prolactin	Homo sapiens	11-20
4780695-10	1973	The stimulation of hepatic glucose output by vasopressin is discussed in connexion with the release of glucose and water from the liver.	Water	115-120	arginine vasopressin	Rattus norvegicus	45-56
4355340-0	1973	The S-100 protein in water-soluble and pentanol-extractable form in normal human brain and tumours of the human nervous system.	Water	21-26	S100 calcium binding protein A1	Homo sapiens	4-9
4377498-0	1974	Effect of a competitive antagonist (8-leu-angiotensin II) of angiotensin II on sodium and water transport in toad skin.	Water	90-95	angiotensinogen	Homo sapiens	42-56
4377498-0	1974	Effect of a competitive antagonist (8-leu-angiotensin II) of angiotensin II on sodium and water transport in toad skin.	Water	90-95	angiotensinogen	Homo sapiens	61-75
16992442-4	1974	Pharmacological doses of ADH are capable of increasing the rate of cutaneous water loss in human subjects who are close to or above the thermal sweating threshold.4.	Water	77-82	arginine vasopressin	Homo sapiens	25-28
4800041-2	1973	A clinical study of the "water-electrolyte regulation mechanism" in chronic congestive heart failure with emphasis on renin and catecholamine].	Water	25-30	renin	Homo sapiens	118-123
4353653-1	1973	Angiotensin II applied directly to the subfornical organ in a dose as small as 0.1 nanogram elicited short-latency drinking behavior in water-sated rats.	Water	136-141	angiotensinogen	Rattus norvegicus	0-14
4721048-1	1973	Rebinding of carbon monoxide to myoglobin and to cytochrome P-450 after removal by a light flash occurs down to 50 degrees K for myoglobin and 25 degrees K for cytochrome P-450 in glycerol-water solution.	Water	189-194	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	49-65
4721048-1	1973	Rebinding of carbon monoxide to myoglobin and to cytochrome P-450 after removal by a light flash occurs down to 50 degrees K for myoglobin and 25 degrees K for cytochrome P-450 in glycerol-water solution.	Water	189-194	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	160-176
4542575-3	1973	After a 90 min period of efflux, the insulin-treated muscles contained approximately 11% less intracellular water than did their controls.	Water	108-113	insulin	Homo sapiens	37-44
4352609-1	1973	Colchicine, vinblastine, podophyllotoxin, and cytochalasin B inhibit the action of vasopressin and cyclic adenosine monophosphate on osmotic water movement across the toad bladder.	Water	141-146	arginine vasopressin	Homo sapiens	83-94
4145433-0	1973	Inhibition of vasopressin-stimulated water transport across the isolated toad bladder.	Water	37-42	arginine vasopressin	Homo sapiens	14-25
4722527-0	1973	Water-losing action of antidiuretic hormone in the presence of excess cortisol: restoration of normal action by prolactin or by oxytocin.	Water	0-5	arginine vasopressin	Homo sapiens	23-43
4703229-2	1973	The present report presents evidence for a vasopressin-sensitive pathway for the movement of urea, other amides, and certain non-amides, which is independent of water flow.	Water	161-166	arginine vasopressin	Homo sapiens	43-54
4738638-0	1973	[Enzymatic studies on water-insoluble derivatives of semi-alkaline proteinase].	Water	22-27	endogenous retrovirus group K member 25	Homo sapiens	67-77
4348766-0	1973	Bilayer lipid membrane as a model for vasopressin, prostaglandin and Ca 2+  effects on water permeability.	Water	87-92	arginine vasopressin	Homo sapiens	38-49
4359806-0	1973	Lever-pressing behavior caused by intraseptal angiotensin II in water satiated rats.	Water	64-69	angiotensinogen	Rattus norvegicus	46-60
4707697-0	1973	The influence of gastrin on the fecal and urinary excretion of water, calcium, magnesium, and inorganic phosphorus in sheep.	Water	63-68	gastrin	Ovis aries	17-24
4633693-2	1973	The average concentrations of PCB"s in the surface water of the Sargasso Sea are lower than those in the northern North Atlantic.	Water	51-56	pyruvate carboxylase	Homo sapiens	30-33
24473968-3	1973	When the availability of water in the xylem is reduced by withholding water, the rate of exudation decreases sharply and this is accompanied by a rise in the sap concentration.	Water	25-30	SH2 domain containing 1A	Homo sapiens	158-161
24473968-4	1973	On removing the water stress, the rate increases rapidly with a corresponding fall in sap concentration.Small variations in water availability do not give significant results and may be buffered by responses from the plant itself.	Water	16-21	SH2 domain containing 1A	Homo sapiens	86-89
4542069-0	1973	The effect of diabetes mellitus and insulin on the absorption of glucose, water and electrolytes by the small intestine in man.	Water	74-79	insulin	Homo sapiens	36-43
4345637-5	1973	Many similarities were found between this effect and the physiological increase in water permeability (hydrosmotic response) elicited by antidiuretic hormone (ADH): both were dependent on the physiological state of the animals, and although the response was slower after hyperosmolar than after hormonal challenge, the patterns of response were similar, and in both cases markedly dependent on bathing solution temperature.	Water	83-88	arginine vasopressin	Homo sapiens	137-157
4775779-0	1973	[Role of antidiuretic hormone in disorders of water-electrolyte metabolism in cardiac insufficiency].	Water	46-51	arginine vasopressin	Homo sapiens	9-29
4345637-5	1973	Many similarities were found between this effect and the physiological increase in water permeability (hydrosmotic response) elicited by antidiuretic hormone (ADH): both were dependent on the physiological state of the animals, and although the response was slower after hyperosmolar than after hormonal challenge, the patterns of response were similar, and in both cases markedly dependent on bathing solution temperature.	Water	83-88	arginine vasopressin	Homo sapiens	159-162
4508326-2	1972	The conformation of deamino-lysine-vasopressin in water differs from that of lysine-vasopressin in the same solvent.	Water	50-55	arginine vasopressin	Homo sapiens	35-46
4116979-0	1972	The influence of protected water supplies on the spread of classical-Inaba and El Tor-Ogawa cholera in rural East Bengal.	Water	27-32	RAR related orphan receptor C	Homo sapiens	82-85
4629080-0	1972	Salicylate effects on vasopressin-stimulated water transport across toad bladder.	Water	45-50	arginine vasopressin	Homo sapiens	22-33
4506776-0	1972	Method for correlation of proton magnetic resonance assignments in different solvents: conformational transition of oxytocin and lysine vasopressin from dimethylsulfoxide to water.	Water	174-179	arginine vasopressin	Homo sapiens	136-147
4636730-0	1972	A rhodopsin-lipid-water lamellar system: its characterisation by x-ray diffraction and electron microscopy.	Water	18-23	rhodopsin	Homo sapiens	2-11
5083169-0	1972	Renin responses to water restriction and rehydration.	Water	19-24	renin	Ovis aries	0-5
5083169-3	1972	During water restriction the plasma concentrations of renin, protein and sodium rose while aldosterone levels were low or undetectable.	Water	7-12	renin	Ovis aries	54-59
5083169-9	1972	If there was a single stimulus to renin release during water restriction and rehydration, it was not an alteration in vascular or extravascular volume, total body sodium, systemic B.P.	Water	55-60	renin	Ovis aries	34-39
4506776-1	1972	The peptide amide, primary carboxamide, and aromatic proton resonances were assigned to specific hydrogens of oxytocin and lysine vasopressin (Lys-VP) in water at 23 degrees at pH 2.5 and 4.2, respectively.	Water	154-159	arginine vasopressin	Homo sapiens	130-141
4348869-0	1972	Water and sodium chloride intake following microinjections of angiotensin II into the septal area of the rat brain.	Water	0-5	angiotensinogen	Rattus norvegicus	62-76
5054473-2	1972	A decrease of catalase activity (CA) in the presence of AT can be taken as evidence of excess formation or accumulation of H(2)O(2).	Water	123-128	catalase	Mus musculus	14-22
4506086-2	1972	The conformation of lysine-vasopressin in water differs from its conformation in dimethylsulfoxide.	Water	42-47	arginine vasopressin	Homo sapiens	27-38
5045096-0	1972	[Adsorption of water vapors by alpha-chymotrypsin and lysozyme].	Water	15-20	lysozyme	Homo sapiens	54-62
4342065-0	1972	Effects of renin and angiotensin on water intake.	Water	36-41	renin	Homo sapiens	11-16
4340438-0	1972	[Renin-angiotensin-aldosterone system in water-electrolyte homeostasis].	Water	41-46	renin	Homo sapiens	1-6
4623851-7	1972	Activation energies for net water movement were now 8.5 kcal/mole (4 degrees -9 degrees C) and 4.1 kcal/mole (9 degrees -20 degrees C), indicating that the components of the aqueous channel undergo conformational changes as the temperature is lowered from 20 degrees C. At 43 degrees C bladder reactivity to vasopressin was lost, and irreversible changes in selective permeability were observed.	Water	28-33	arginine vasopressin	Homo sapiens	308-319
5057131-1	1972	The effect of antidiuretic hormone on water flows in isolated mammalian collecting tubules.	Water	38-43	arginine vasopressin	Homo sapiens	14-34
5057131-2	1972	These experiments were intended to evaluate the effects of antidiuretic hormone (ADH) on dissipative water transport in cortical collecting tubules isolated from rabbit kidney.	Water	101-106	arginine vasopressin	Homo sapiens	59-79
5057131-2	1972	These experiments were intended to evaluate the effects of antidiuretic hormone (ADH) on dissipative water transport in cortical collecting tubules isolated from rabbit kidney.	Water	101-106	arginine vasopressin	Homo sapiens	81-84
5057131-6	1972	These data suggest that ADH increased the water permeability of the luminal membranes of the tubules.	Water	42-47	arginine vasopressin	Homo sapiens	24-27
5057131-7	1972	It was possible that the ADH-dependent P(f)/P(DW) ratio was referable to the resistance of the epithelial cell layer (exclusive of luminal membranes) to water diffusion (R(DW), sec cm(-1)).	Water	153-158	arginine vasopressin	Homo sapiens	25-28
5020985-4	1972	During infusion of vasopressin at a rate of 0.025 m-u./kg.min and 0.1 m-u./kg.min there was no statistically significant increase in free water clearance during left atrial distension but there were variations in free water clearance in individual experiments.4.	Water	218-223	arginine vasopressin	Homo sapiens	19-30
5057132-2	1972	In one group of experiments, the ADH-dependent osmotic water flows, when the perfusing solutions contained hypotonic NaCl solutions, were indistinguishable from control observations when either urea or sucrose replaced, in part, NaCl in isotonic bathing solutions (cortical collecting tubules).	Water	55-60	arginine vasopressin	Homo sapiens	33-36
5057132-7	1972	Since the limiting sites for urea penetration were the luminal interfaces of the tubules, these data are consistent with the view that ADH increases diffusional water flow across such interfaces.	Water	161-166	arginine vasopressin	Homo sapiens	135-138
4339189-0	1972	Water of co-ordination in insulin.	Water	0-5	insulin	Homo sapiens	26-33
5020985-5	1972	During infusion of vasopressin in doses of 0.4 m-u./kg.min and 1.0 m-u./kg.min changes in free water clearance were dependent upon changes in osmolal clearance indicating that these doses of vasopressin provided a maximum antidiuretic effect.5.	Water	95-100	arginine vasopressin	Homo sapiens	19-30
5020985-5	1972	During infusion of vasopressin in doses of 0.4 m-u./kg.min and 1.0 m-u./kg.min changes in free water clearance were dependent upon changes in osmolal clearance indicating that these doses of vasopressin provided a maximum antidiuretic effect.5.	Water	95-100	arginine vasopressin	Homo sapiens	191-202
4358411-13	1972	on the serosal surface also inhibits the transport of water facilitated by vasopressin in the toad bladder.	Water	54-59	arginine vasopressin	Rattus norvegicus	75-86
5007642-0	1972	The intrinsic viscosities of bovine serum albumin in n-propyl alcohol-water mixtures.	Water	70-75	albumin	Homo sapiens	36-49
5016043-13	1972	The evidence is discussed that the action of vasopressin involves factors apart from increasing the permeability of the distal nephron to water and urea.	Water	138-143	arginine vasopressin	Rattus norvegicus	45-56
5053844-0	1972	Changes in hepatic and erythrocyte transketolase activity and thiamine concentration of liver in experimental deficiency of water soluble vitamins.	Water	124-129	transketolase	Homo sapiens	35-48
4648844-0	1972	[Effect of the antidiuretic hormone (ADH) on water transfer values in human fetal membranes in vitro].	Water	45-50	arginine vasopressin	Homo sapiens	15-35
4648844-0	1972	[Effect of the antidiuretic hormone (ADH) on water transfer values in human fetal membranes in vitro].	Water	45-50	arginine vasopressin	Homo sapiens	37-40
5051374-0	1972	The effect of water temperature on the snail intermediate hosts of schistosomiasis in Egypt.	Water	14-19	snail family transcriptional repressor 1	Homo sapiens	39-44
5145324-0	1971	Bioassay and radioimmunoassay of vasopressin in relation to water metabolism.	Water	60-65	arginine vasopressin	Homo sapiens	33-44
5069359-0	1972	The effect of water movements on the snail intermediate hosts of Schistosomiasis in Egypt.	Water	14-19	snail family transcriptional repressor 1	Homo sapiens	37-42
4349167-0	1972	Effects of a week of ACTH or corticosteroid treatment on the diuretic response to water intake.	Water	82-87	proopiomelanocortin	Homo sapiens	21-25
24174234-2	1971	It was shown: (1) that when bladders incubated with a hypotonic mucosal medium are water-permeabilized with oxytoxin, arginine-vasotocin, cyclic 3",5"-AMP and theophylline, this leads to a cellular swelling and the opening of intercellular channels; (2) that these effects are not observed when the transepithelial net water flow is suppressed by abolishing the external osmotic driving force; and (3) that modifications in the rate of active sodium transport do not change the morphological appearance of intercellular channels.These results are expecially discussed with respect to the localization to the intracellular site of the final effect of antidiuretic hormone on water permeability, and to the role of intercellular channels in the transepithelial transfer of water and sodium.	Water	83-88	arginine vasopressin	Homo sapiens	650-670
5138037-0	1971	[Interrelation of water, sodium and potassium in the arterial wall and renin activity in the kidney in renal hypertension].	Water	18-23	renin	Homo sapiens	71-76
5090063-0	1971	Role of antidiuretic hormone in the abnormal water diuresis of anterior hypopituitarism in man.	Water	45-50	arginine vasopressin	Homo sapiens	8-28
5146570-1	1971	Comparative dilatometric study of acid-base reactions of lysozyme and ovalbumin in water and denaturing media.	Water	83-88	lysozyme	Homo sapiens	57-65
5090063-1	1971	To evaluate the role of antidiuretic hormone (ADH) in the defect in water excretion which is characteristic of glucocorticoid deficiency, the effects of hydrocortisone and ethanol upon urinary dilution during a sustained water load were studied in patients with anterior hypopituitarism.	Water	68-73	arginine vasopressin	Homo sapiens	24-44
5087846-0	1971	Preparation and properties of water-insoluble thrombin.	Water	30-35	coagulation factor II, thrombin	Homo sapiens	46-54
5090063-1	1971	To evaluate the role of antidiuretic hormone (ADH) in the defect in water excretion which is characteristic of glucocorticoid deficiency, the effects of hydrocortisone and ethanol upon urinary dilution during a sustained water load were studied in patients with anterior hypopituitarism.	Water	68-73	arginine vasopressin	Homo sapiens	46-49
4325462-2	1971	Recently it has been shown that injection of angiotensin II into the anterior diencephalon causes the rat to drink water.	Water	115-120	angiotensinogen	Rattus norvegicus	45-59
24173388-1	1971	Isolated sheets of epithelial cells as well as epithelial cells scraped from paired hemibladders mounted in chambers both showed significant increases in water, sodium and chloride contents after exposure to vasopressin (100 mU/ml), without any change in potassium content.	Water	154-159	arginine vasopressin	Homo sapiens	208-219
24173389-2	1971	Cryptic activity of the enzymes was demonstrated by an increase in activity on dilution with water, which caused fragmentation of the ghosts.	Water	93-98	cripto, FRL-1, cryptic family 1	Homo sapiens	0-7
5557813-0	1971	[Formation and stability of water-soluble complexes of insulin with polyacrylic and polymethacrylic acids].	Water	28-33	insulin	Homo sapiens	55-62
4399668-0	1971	Glycine-amide effect on the vasopressin stimulated sodium and water transport across toad bladder.	Water	62-67	arginine vasopressin	Homo sapiens	28-39
5552404-1	1971	The activation energy (E(A)) for the diffusion of water across the epithelial cell layer of the toad bladder was determined in the absence and presence of vasopressin.	Water	50-55	arginine vasopressin	Homo sapiens	155-166
5575414-0	1971	Simultaneous measurement of the effect of vasopressin on sodium and water transport across toad bladder.	Water	68-73	arginine vasopressin	Homo sapiens	42-53
4928601-0	1971	Effect of water activity on enterotoxin B production and growth of Staphylococcus aureus.	Water	10-15	Enterotoxin	Staphylococcus aureus	28-39
4325462-7	1971	Synthetic tetradecapeptide renin substrate and angiotensin I were as effective as angiotensin II at causing water-replete rats to drink.4.	Water	108-113	angiotensinogen	Rattus norvegicus	82-96
4262062-0	1971	[Short term effects of arginine-vasopressin on water consumption in the rat].	Water	47-52	arginine vasopressin	Rattus norvegicus	32-43
5092545-0	1971	The effects of substituting solutions of urea, glucose and potassium chloride for drinking water on the neurohypophysial vasopressin content of rats.	Water	91-96	arginine vasopressin	Rattus norvegicus	121-132
4332863-0	1971	Effects of centrally administered angiotensin II on salt and water excretion.	Water	61-66	angiotensinogen	Homo sapiens	34-48
5101300-3	1971	The presence of endogenous vasopressin was indicated by the patient"s ability to concentrate the urine to as high as 710 mOsm/kg of water with a creatinine clearance of 84 cc/min, and by dilution of the urine in response to alcohol.	Water	132-137	arginine vasopressin	Homo sapiens	27-38
4257741-0	1971	[Participation of the antidiuretic hormone (ADH) in the activity of chlorpropamide on water metabolism, in toads].	Water	86-91	arginine vasopressin	Homo sapiens	22-42
4257741-0	1971	[Participation of the antidiuretic hormone (ADH) in the activity of chlorpropamide on water metabolism, in toads].	Water	86-91	arginine vasopressin	Homo sapiens	44-47
4914435-5	1970	Nine of these 11 patients underwent bilateral nephrectomy; in each of the seven in whom the post operative result could be evaluated the blood pressure returned rapidly to normal.Plasma renin activity, measured in 34 subjects, was raised above normal in six out of nine patients whose blood pressure could not be controlled by salt and water depletion and in one of the 11 patients whose blood pressure could be so controlled, but was within the normal range in all nine normotensive patients.	Water	336-341	renin	Homo sapiens	186-191
5274441-0	1970	Proton nuclear magnetic resonance studies of myoglobin in H2O.	Water	58-61	myoglobin	Equus caballus	45-54
4915450-1	1970	Phase microscopy of toad urinary bladder has demonstrated that vasopressin can cause an enlargement of the epithelial intercellular spaces under conditions of no net transfer of water or sodium.	Water	178-183	arginine vasopressin	Homo sapiens	63-74
24174151-0	1970	The role of water diffusion in the action of vasopressin.	Water	12-17	arginine vasopressin	Homo sapiens	45-56
24174151-1	1970	Vasopressin produces a large increase in the osmotic flow of water across the toad bladder, with little apparent change in the diffusion rate of tritiated water.	Water	61-66	arginine vasopressin	Homo sapiens	0-11
24174151-3	1970	The present studies show that there is in fact a large (at least 10-fold) increase in water diffusion subsequent to addition of vasopressin, which is masked by unstirred layers and by the resistance offered to diffusion by the thick layer of connective tissue and muscle supporting the bladder epithelial cells.	Water	86-91	arginine vasopressin	Homo sapiens	128-139
24174151-5	1970	An alternative to the pore hypothesis is considered, in which vasopressin acts solely by increasing the diffusion rate of water across the luminal membrane of the epithelial cell.	Water	122-127	arginine vasopressin	Homo sapiens	62-73
4924914-0	1970	Conditioning of allogeneic skin grafts recipients with crude and water soluble H-2 antigens derived from BP-8 murine tumor cell membranes.	Water	65-70	histocompatibility-2, MHC	Mus musculus	79-82
4322723-2	1970	When applied directly to the brain, angiotensin II amide, as either the valine(5) octapeptide, causes rats in normal fluid balance to drink water.2.	Water	140-145	angiotensinogen	Rattus norvegicus	36-50
4914435-6	1970	The mean level of plasma renin activity in the first group was significantly higher than that of each of the other two groups.There was a significant correlation between hypertension during dialysis and after transplantation, suggesting that, in addition to renin, there is a non-renal factor which predisposes certain patients to hypertension in the presence of salt and water excess.	Water	372-377	renin	Homo sapiens	25-30
5537566-0	1970	[Test of the effect of Lechere water on variation of prothrombin levels].	Water	31-36	coagulation factor II, thrombin	Homo sapiens	53-64
5468280-0	1970	Vasopressin content and neurosecretory material in the hypothalamo-neurohypophyseal system of rats under different states of water metabolism.	Water	125-130	arginine vasopressin	Rattus norvegicus	0-11
5461614-0	1970	Preparation and properties of crosslinked water-insoluble catalase.	Water	42-47	catalase	Homo sapiens	58-66
4314166-18	1970	(3)H from compounds such as l-[2-(3)H]lactate, which form NAD(3)H in the cytosol, appears in part in water; and (3)H from dl-beta-hydroxy[3-(3)H]butyrate, which forms NAD(3)H in the mitochondria, appears in part in glucose, largely on C-4.	Water	101-106	complement C4A	Rattus norvegicus	235-238
5491100-0	1970	Effects of ACTH and corticosteroids in the regulation of food and water intake.	Water	66-71	proopiomelanocortin	Homo sapiens	11-15
4313295-0	1970	Active water-insoluble derivative of renin.	Water	7-12	renin	Homo sapiens	37-42
4902827-5	1970	However, when rats were fed the same solution of ammonium chloride but were allowed access to tap water ad lib., urinary osmolality values were comparable to those observed in normal animals, and susceptibility to pyelonephritis was reduced or eliminated despite a degree of systemic acidosis similar to that observed in rats fed ammonium chloride solution without access to tap water.	Water	98-103	nuclear RNA export factor 1	Rattus norvegicus	94-97
4309308-8	1969	Insulin increased the uptake by isolated heart cells of several (14)C-labelled naturally occurring amino acids; however, the fraction of amino acid taken up by the cells that was recovered free intracellularly, and therefore the concentration ratio (between intracellular water and medium), was enhanced by the hormone only with glycine, proline, serine, threonine, histidine and methionine.	Water	272-277	insulin	Gallus gallus	0-7
24174043-6	1969	The results demonstrate that the action of vasopressin to enhance bulk water flow across toad bladder is exerted specifically on the apical surface of the granular cells.	Water	71-76	arginine vasopressin	Homo sapiens	43-54
24174047-15	1969	The polycation produced a small but significant increase in osmotic water flow, and striking and irreversible inhibition of the water-flow response to vasopressin.	Water	128-133	arginine vasopressin	Homo sapiens	151-162
4187459-8	1969	It is concluded that the rapid transfer of sodium and water from the circulation to the rumen via the saliva during ingestion of dry feed is sufficient to activate the renin/angiotensin system.	Water	54-59	renin	Ovis aries	168-173
4186511-7	1969	Addition of sodium pyruvate, which inhibits endogenous generation of H(2)O(2) by tissue oxidases, or of crystalline catalase, which decomposes such tissue-generated H(2)O(2), completely abolished microbody staining in the absence of H(2)O(2).	Water	165-170	catalase	Rattus norvegicus	116-124
4186511-7	1969	Addition of sodium pyruvate, which inhibits endogenous generation of H(2)O(2) by tissue oxidases, or of crystalline catalase, which decomposes such tissue-generated H(2)O(2), completely abolished microbody staining in the absence of H(2)O(2).	Water	165-170	catalase	Rattus norvegicus	116-124
4980929-3	1969	Hexokinase activity was labile in distilled water hemolysates but was only slightly low when protected by glucose, mercaptoethanol, and ethylenediaminetetraacetate (EDTA).	Water	44-49	hexokinase 1	Homo sapiens	0-10
5821009-2	1969	The interaction between [(14)C]carboxymethylated cytochrome c and monolayers of egg phosphatidylethanolamine at the air/water interface has been investigated by measurements of surface radioactivity, pressure and potential.	Water	120-125	cytochrome c, somatic	Homo sapiens	49-61
5769701-0	1969	Dielectric measurements of water sorbed on ovalbumin and lysozyme.	Water	27-32	lysozyme	Homo sapiens	57-65
5792362-3	1969	Insulin in low concentrations inhibits the uptake of Ca(++) by the monooctadecyl (stearyl) phosphate monolayer (at air-water interface) and facilitates the release of Ca(++) adsorbed to the monolayer.	Water	119-124	insulin	Homo sapiens	0-7
5793245-1	1969	Vasopressin causes dilation of the intercellular spaces of the mucosal epithelium in toad bladder, an effect previously thought to result from enhanced net transepithelial water transport.	Water	172-177	arginine vasopressin	Homo sapiens	0-11
27096240-4	1969	Some water samples gave good agreement on soluble vitamin B12 by all 3 methods, while other samples had appreciable discrepancies.	Water	5-10	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	58-61
17731763-0	1969	Solubility in water of normal c9 and c10, alkane hydrocarbons.	Water	14-19	homeobox C10	Homo sapiens	37-40
5787105-0	1969	The effect of glucola, diet cola and water ingestion on blood glucose and plasma insulin.	Water	37-42	insulin	Homo sapiens	81-88
5780194-4	1969	Indirect evidence was obtained that the effect of adrenal steroid hormones on the osmotic water flow response to vasopressin is mediated by a different hormone-tissue interaction than that mediating the effect of adrenal steroid hormones on sodium transport.	Water	90-95	arginine vasopressin	Homo sapiens	113-124
5780194-5	1969	In experiments with three different pairs of mineralocorticoid and glucocorticoid analogues, the former had a greater effect on short-circuit current, the latter on the osmotic water flow response to vasopressin.	Water	177-182	arginine vasopressin	Homo sapiens	200-211
4387556-0	1969	Tyramine, catecholamines and the action of vasopressin on stimulation of water efflux in toad bladders.	Water	73-78	arginine vasopressin	Homo sapiens	43-54
5762042-7	1969	The effects of ADH have been interpreted in terms of the formation of water-filled sodium-permselective pores in the outer facing membranes which occupy, at most, 0.3% of the skin surface.	Water	70-75	arginine vasopressin	Homo sapiens	15-18
4307191-0	1969	Micropuncture study of the action of angiotensin-II on tubular sodium and water reabsorption in the rat.	Water	74-79	angiotensinogen	Rattus norvegicus	37-51
5814896-0	1969	[Vasopressin-water equivalent under different starting conditions in the conscious rat].	Water	13-18	arginine vasopressin	Rattus norvegicus	1-12
4306624-0	1969	[Effect of angiotensin II on tubular sodium and water reabsorption in the rat].	Water	48-53	angiotensinogen	Rattus norvegicus	11-25
5682476-0	1968	The thickness of adsorbed films of bovine serum albumin at the air-water interface.	Water	67-72	albumin	Homo sapiens	42-55
16656981-2	1968	The sap pressure in trees and bushes standing in several meters of water was found to average between -15 and -20 atm in sunshine.	Water	67-72	SH2 domain containing 1A	Homo sapiens	4-7
4883828-0	1968	Direct isolation of thiol-containing peptides from insulin using a water-insoluble organomercurial copolymer of ethylene and maleic acid.	Water	67-72	insulin	Homo sapiens	51-58
5637142-4	1968	In 10 subjects given 10-20 mU of vasopressin per hr during phases 2 and 3, free water clearance decreased significantly from phase 1 to phase 2 (9.3 to 0.15, P = 0.001) and increased during phase 3 norepinephrine infusion to 4.7 ml/min (P = 0.001).	Water	80-85	arginine vasopressin	Homo sapiens	33-44
5657333-3	1968	During vasopressin-suppressed water diuresis, 4-leucine-oxytocin produced similar effects on urine and electrolyte excretions.	Water	30-35	arginine vasopressin	Rattus norvegicus	7-18
5657333-4	1968	In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to freewater clearance.	Water	55-60	arginine vasopressin	Rattus norvegicus	30-41
5660636-6	1968	Insulin enhanced the rate of alpha-aminoisobutyric acid accumulation and increased the value of its final concentration in the cell water.	Water	132-137	insulin	Gallus gallus	0-7
5648834-7	1968	It is proposed that vasopressin acts by greatly increasing the rate of diffusion of water across an outer barrier of the membrane, with little or no accompanying increase in pore size.	Water	84-89	arginine vasopressin	Homo sapiens	20-31
5673348-0	1968	Insulin: intestinal absorption as water-in-oil-in-water emulsions.	Water	34-39	insulin	Homo sapiens	0-7
5673348-0	1968	Insulin: intestinal absorption as water-in-oil-in-water emulsions.	Water	50-55	insulin	Homo sapiens	0-7
5645853-0	1968	Effect of antidiuretic hormone on human small intestinal water and solute transport.	Water	57-62	arginine vasopressin	Homo sapiens	10-30
5668653-0	1968	Films of lysozyme adsorbed at air-water surfaces.	Water	34-39	lysozyme	Homo sapiens	9-17
5652885-2	1968	Indirect evidence suggests that the concentration of arginine vasopressin in the plasma of normally hydrated man is about 1 mu-u./ml., but this is usually considered to be below the limit of sensitivity of the standard assay preparation, the water-loaded Wistar rat under ethanol anaesthesia.2.	Water	242-247	arginine vasopressin	Homo sapiens	62-73
4174334-0	1968	The effect of vasopressin on the urinary electrolytes in water-loaded rats.	Water	57-62	arginine vasopressin	Rattus norvegicus	14-25
5637142-6	1968	Creatinine clearance, osmolal clearance, and sodium and chloride excretion were unchanged throughout the studies in both groups of subjects.A two phase study in seven subjects confirmed that 10, 20, or 75 mU of vasopressin per hr susstained antidiuresis during phase 2 for at least 2 hr and that free water clearance values were essentially constant in the individual subject after the first 30 min of infusion.	Water	301-306	arginine vasopressin	Homo sapiens	211-222
5637142-8	1968	A post-phase 3 infusion of vasopressin in four subjects resulted in a marked decrease in free water clearance, indicating that the norepinephrine inhibition of vasopressin antidiuresis was not accountable on the basis of decreased medullary hypertonicity.	Water	94-99	arginine vasopressin	Homo sapiens	27-38
5758012-0	1968	[Effects of the Mateczny II spring water in Cracow on the action of insulin].	Water	35-40	insulin	Homo sapiens	68-75
5242868-2	1968	The vasopressin-water-equivalent and vasopressin clearance by the kidney.	Water	16-21	arginine vasopressin	Rattus norvegicus	4-15
6058314-0	1967	Intravenous infusion of vasopressin to increase the sensitivity of its assay in the water-ethanol loaded rat.	Water	84-89	arginine vasopressin	Rattus norvegicus	24-35
6070259-0	1967	Acetylcholinesterase inhibition by micropollutants in drinking water.	Water	63-68	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
16656636-7	1967	These results suggest that water stress directly affected ribonuclease activity at the cellular level.	Water	27-32	intracellular ribonuclease LX	Solanum lycopersicum	58-70
5760501-2	1968	The water content of hemagglutinin].	Water	4-9	hemagglutinin	Vaccinia virus	21-34
4967072-6	1967	Ammonium sulphate treatment generates a Mn(2+)-stimulated aminopeptidase that is stable to dialysis against EDTA and water, in contrast with an endogenous Mn(2+)-activated preparation that is irreversibly denatured by such dialysis against EDTA and water.	Water	117-122	carboxypeptidase Q	Homo sapiens	58-72
4967072-6	1967	Ammonium sulphate treatment generates a Mn(2+)-stimulated aminopeptidase that is stable to dialysis against EDTA and water, in contrast with an endogenous Mn(2+)-activated preparation that is irreversibly denatured by such dialysis against EDTA and water.	Water	249-254	carboxypeptidase Q	Homo sapiens	58-72
6033707-2	1967	Ice as a possible model for biological structured-water systems.	Water	50-55	carboxylesterase 2	Homo sapiens	0-3
6049001-0	1967	Transient saluresis due to lysine-vasopressin administration in the conscious water diuretic rat.	Water	78-83	arginine vasopressin	Rattus norvegicus	34-45
17839615-0	1967	Metastable Superheated Ice in Liquid-Water Inclusions under High Negative Pressure.	Water	37-42	carboxylesterase 2	Homo sapiens	23-26
5996672-0	1966	Action of water-insoluble trypsin derivatives on fibrinogen clottability.	Water	10-15	fibrinogen beta chain	Homo sapiens	49-59
6018744-8	1967	Plasma AVP was abnormally elevated during mild dehydration and remained above the normal range despite hemodilution in patients with untreated adrenocortical insufficiency demonstrating a delayed water diuresis.	Water	196-201	arginine vasopressin	Homo sapiens	7-10
6018744-11	1967	These findings suggest that hypersecretion of AVP may play an important role in the abnormal water metabolism of adrenocortical insufficiency and that the glucosteroids promote normal water diuresis by inhibiting the secretion of AVP from the neurohypophysis.	Water	93-98	arginine vasopressin	Homo sapiens	46-49
5615061-0	1967	[Identification of insulin fractions in water solutions by starch-gel electrophoresis method].	Water	40-45	insulin	Homo sapiens	19-26
5988794-0	1966	[The change in excitability of the alimentary center in albino rats during the internal application of waters from the Piatigorsk Spa No.	Water	103-109	surfactant protein A1	Rattus norvegicus	130-133
16742415-4	1966	Crude growth hormone was purified by gel filtration on Sephadex, resulting in a product that is soluble in water or 0.5% sodium chloride.	Water	107-112	growth hormone 1	Homo sapiens	6-20
5917071-5	1966	The normal or higher concentrations of the water-solublevitamins in test milk show that the biosynthesis of these vitamins in the rumen is vigorous.	Water	43-48	Weaning weight-maternal milk	Bos taurus	73-77
5954509-0	1966	[Bath-tub for individual water exercises].	Water	25-30	TUB bipartite transcription factor	Homo sapiens	6-9
5942183-0	1966	[Constantly negative clearances of free water (inappropriate secretion of paraneoplastic ADH (antidiuretic hormone), adrenal insufficiency, cranial injury)].	Water	40-45	arginine vasopressin	Homo sapiens	94-114
5940962-0	1966	Action of water-insoluble trypsin derivatives on prothrombin and related clotting factors.	Water	10-15	coagulation factor II, thrombin	Homo sapiens	49-60
5234143-3	1966	injection of vasopressin: the vasopressin water equivalent.	Water	42-47	arginine vasopressin	Rattus norvegicus	13-24
5234143-3	1966	injection of vasopressin: the vasopressin water equivalent.	Water	42-47	arginine vasopressin	Rattus norvegicus	30-41
4380024-0	1966	The effect of thiols and ganglioside on the alterations in water, sodium and potassium distribution produced in brain slices by vasopressin and protamine.	Water	59-64	arginine vasopressin	Homo sapiens	128-139
5938558-0	1966	Effects of bradykinin on the movement of water and sodium in some isolated living membranes.	Water	41-46	kininogen 1	Homo sapiens	11-21
5829184-0	1965	Effects of water-insoluble trypsin derivatives on fibrinogen.	Water	11-16	fibrinogen beta chain	Homo sapiens	50-60
5861834-0	1965	The effect of vasopressin on water distribution in the rat kidney.	Water	29-34	arginine vasopressin	Rattus norvegicus	14-25
14284891-0	1965	[THE EFFECT OF COMBINED INFUSION OF L-NORADRENALINE AND ANGIOTENSIN II ON THE RENAL WATER-ELECTROLYTE EXCRETION IN NORMAL PERSONS.	Water	84-89	angiotensinogen	Homo sapiens	56-70
5883801-0	1965	[On the characteristics of water of the Arno river middle course].	Water	27-32	cytohesin 2	Homo sapiens	40-44
14288793-0	1965	[THE ROLE OF THE PITUITARY ANTIDIURETIC HORMONE IN THE MECHANISM OF WATER METABOLISM DISORDERS IN HEPATIC PATHOLOGY].	Water	68-73	arginine vasopressin	Homo sapiens	27-47
13947535-0	1963	Adsorbed films of bovine serum albumin: tensions at air-water surfaces and paraffin-water interfaces.	Water	56-61	albumin	Homo sapiens	25-38
4380863-0	1964	The role of adenosine 3",5"-phosphate in the action of vasopressin on water permeability of toad bladders.	Water	70-75	arginine vasopressin	Homo sapiens	55-66
14101494-0	1963	THE MECHANISM OF INCREASED SODIUM  EXCRETION DURING WATER LOADING WITH 2-5 PERCENT DEXTROSE AND VASOPRESSIN.	Water	52-57	arginine vasopressin	Homo sapiens	96-107
14283074-0	1965	RECTIFICATION OF WATER FLOW ACROSS THE BLADDER OF THE TOAD; EFFECT OF  VASOPRESSIN.	Water	17-22	arginine vasopressin	Homo sapiens	71-82
14133779-0	1964	ABNORMALITIES OF ANTIDIURETIC HORMONE CONTROL OF BODY WATER HOMEOSTASIS.	Water	54-59	arginine vasopressin	Homo sapiens	17-37
14107456-1	1964	Mice genetically susceptible to alcohol orientation were allowed to develop a preference for 10 percent ethanol over tap water.	Water	121-126	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	117-120
13947535-0	1963	Adsorbed films of bovine serum albumin: tensions at air-water surfaces and paraffin-water interfaces.	Water	84-89	albumin	Homo sapiens	25-38
13905689-0	1962	Studies on the movement of water through the isolated toad bladder and its modification by vasopressin.	Water	27-32	arginine vasopressin	Homo sapiens	91-102
13905689-2	1962	In the absence of a transmembrane osmotic gradient, vasopressin increases the unidirectional flux of water from a mean of 340 to a mean of 570 microl per cm(2) per hour but the net water movement remains essentially zero.	Water	101-106	arginine vasopressin	Homo sapiens	52-63
13905689-2	1962	In the absence of a transmembrane osmotic gradient, vasopressin increases the unidirectional flux of water from a mean of 340 to a mean of 570 microl per cm(2) per hour but the net water movement remains essentially zero.	Water	181-186	arginine vasopressin	Homo sapiens	52-63
13905690-4	1962	Activation energies simultaneously determined following vasopressin for diffusion and net transfers of water were similar, and in the same range as known activation energies for diffusion and viscous flow in water.	Water	103-108	arginine vasopressin	Homo sapiens	56-67
14450351-0	1962	Monolayer film of rhodopsin at the air/water interface.	Water	39-44	rhodopsin	Homo sapiens	18-27
13865067-0	1962	Effect of vasopressin structural modifications on rat renal excretion of Na, K, and water.	Water	84-89	arginine vasopressin	Rattus norvegicus	10-21
13905690-8	1962	Vasopressin enlarges the aqueous channels so that the core of water they contain possesses the physical properties of ordinary bulk water.	Water	62-67	arginine vasopressin	Homo sapiens	0-11
13905690-8	1962	Vasopressin enlarges the aqueous channels so that the core of water they contain possesses the physical properties of ordinary bulk water.	Water	132-137	arginine vasopressin	Homo sapiens	0-11
13682358-2	1961	Influence of oxygen and absorbed water on changes produced in bovine serum albumin.	Water	33-38	albumin	Homo sapiens	69-82
13884110-1	1962	Water velocity is an important physical factor in the conditioning of streams and canals as habitats for the intermediate snail host of bilharziasis.	Water	0-5	snail family transcriptional repressor 1	Homo sapiens	122-127
13884110-3	1962	However, the complex nature of water flow through natural and man-made courses makes it very difficult to determine accurately the limiting range of water velocity that allows the settlement and development of snail colonies in a watercourse, and results are therefore still inconclusive.This paper describes the procedure employed in and the results obtained from a study designed to elucidate the water flow phenomenon through analysis of the relative variations of water velocity at any point of the cross-section of the canal.	Water	149-154	snail family transcriptional repressor 1	Homo sapiens	210-215
13884110-3	1962	However, the complex nature of water flow through natural and man-made courses makes it very difficult to determine accurately the limiting range of water velocity that allows the settlement and development of snail colonies in a watercourse, and results are therefore still inconclusive.This paper describes the procedure employed in and the results obtained from a study designed to elucidate the water flow phenomenon through analysis of the relative variations of water velocity at any point of the cross-section of the canal.	Water	149-154	snail family transcriptional repressor 1	Homo sapiens	210-215
13884110-3	1962	However, the complex nature of water flow through natural and man-made courses makes it very difficult to determine accurately the limiting range of water velocity that allows the settlement and development of snail colonies in a watercourse, and results are therefore still inconclusive.This paper describes the procedure employed in and the results obtained from a study designed to elucidate the water flow phenomenon through analysis of the relative variations of water velocity at any point of the cross-section of the canal.	Water	149-154	snail family transcriptional repressor 1	Homo sapiens	210-215
13884110-4	1962	From this study it was possible to derive a simplified method for measuring the rate of water flow in earth canals that may be of wide application in snail control by the use of molluscicides.	Water	88-93	snail family transcriptional repressor 1	Homo sapiens	150-155
14478047-5	1961	Explanations of this apparent phenomenon are discussed and it is concluded that populations of B. truncatus may be completely absent for several years and that other snail genera may play a role in transmitting the disease.A study of environmental factors indicates that water velocities, salinity, turbidity, and pH in the endemic and non-endemic areas showed no significant differences, but that the continuous change in water flow may be a factor limiting B. truncatus colonization.It is also concluded that the salinity in the Shatt al Arab River originates from Lake Hammar and is not introduced from the Persian Gulf by tidal wave, as has been previously believed.	Water	271-276	snail family transcriptional repressor 1	Homo sapiens	166-171
13772880-0	1961	Deuterium-hydrogen exchange between water and insulin.	Water	36-41	insulin	Homo sapiens	46-53
14402637-0	1960	Water conservation following prolonged vasopressin administration.	Water	0-5	arginine vasopressin	Homo sapiens	39-50
14405109-1	1960	Local licking rates of eight albino rats, when the rats were given tap water at the end of a short runway after 23 hours of water deprivation, averaged a little over seven licks per second.	Water	71-76	nuclear RNA export factor 1	Rattus norvegicus	67-70
13771912-0	1960	Neutralization of cod insulin with antiserum: precipitation of insulin-anti-insulin complex with ethanol-water.	Water	105-110	insulin	Homo sapiens	22-29
13771912-0	1960	Neutralization of cod insulin with antiserum: precipitation of insulin-anti-insulin complex with ethanol-water.	Water	105-110	insulin	Homo sapiens	63-70
13771912-0	1960	Neutralization of cod insulin with antiserum: precipitation of insulin-anti-insulin complex with ethanol-water.	Water	105-110	insulin	Homo sapiens	63-70
13668542-1	1959	Mice vaccinated intraperitoneally with a water-in-oil emulsion containing ovalbumin and avirulent tubercle bacilli developed strong immediate and delayed hypersensitivities, demonstrable by intracutaneous injection, to the ovalbumin.	Water	41-46	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	74-83
13837007-1	1959	A survey has been made of the amount of muscle water available to inulin, sucrose, and radioiodinated human serum albumin (RISA).	Water	47-52	albumin	Homo sapiens	108-121
14418666-0	1960	Preliminary survey of radium 226 and radium 228(Ms Thl) contents of drinking water.	Water	77-82	trichohyalin	Homo sapiens	51-54
13668542-1	1959	Mice vaccinated intraperitoneally with a water-in-oil emulsion containing ovalbumin and avirulent tubercle bacilli developed strong immediate and delayed hypersensitivities, demonstrable by intracutaneous injection, to the ovalbumin.	Water	41-46	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	223-232
13561335-0	1958	[Effect of vasopressin on the elimination of water load, sodium and potassium in weanling rats].	Water	45-50	arginine vasopressin	Rattus norvegicus	11-22
13657188-0	1959	[Effect of adrenal cortex hormones on the vasopressin action in water diuresis in intact rats].	Water	64-69	arginine vasopressin	Rattus norvegicus	42-53
13564338-0	1958	Tic douloureux: permanent cure by injection of hot water into gasserian ganglion.	Water	51-56	pleckstrin and Sec7 domain containing 4	Homo sapiens	0-3
13623773-0	1958	[Effect of ACTH on certain phases of mineral and water metabolism in rheumatism and rheumatoid polyarthritis].	Water	49-54	proopiomelanocortin	Homo sapiens	11-15
13449158-0	1957	A study of the quantitative relationship between antidiuretic hormone (vasopressin) and the renal tubular reabsorption of water.	Water	122-127	arginine vasopressin	Homo sapiens	49-69
13479489-0	1957	[Dissociation of insulin in pyridine-water and acetic acid-water solutions].	Water	37-42	insulin	Homo sapiens	17-24
13479489-0	1957	[Dissociation of insulin in pyridine-water and acetic acid-water solutions].	Water	59-64	insulin	Homo sapiens	17-24
13508487-0	1958	[Antidiuretic hormone and its importance for regulation of water metabolism.	Water	59-64	arginine vasopressin	Homo sapiens	1-21
13449158-0	1957	A study of the quantitative relationship between antidiuretic hormone (vasopressin) and the renal tubular reabsorption of water.	Water	122-127	arginine vasopressin	Homo sapiens	71-82
13464569-0	1957	[Changes in distribution of body water during hypoglycemic shock caused by insulin].	Water	33-38	insulin	Homo sapiens	75-82
13346148-0	1956	Effect of the antidiuretic hormone (pitressin) on the insensible water loss of the skin.	Water	65-70	arginine vasopressin	Homo sapiens	14-34
13579356-0	1957	[Transcutaneous loss of water: the antidiuretic hormone as an antiperspirant].	Water	24-29	arginine vasopressin	Homo sapiens	35-55
13448105-0	1957	[Study of clinical aspects and water, sodium and potassium excretion during treatment with ACTH, cortisone and related compounds].	Water	31-36	proopiomelanocortin	Homo sapiens	91-95
13424317-0	1956	Effect of vasopressin and oxytocin on the excretion of water and electrolytes (Na, C1 and K) in the albino rat.	Water	55-60	arginine vasopressin	Rattus norvegicus	10-21
13424324-0	1957	Effect of purified vasopressin and oxytocin on water and sodium excretion in hypophysectomized rats.	Water	47-52	arginine vasopressin	Rattus norvegicus	19-30
13348671-0	1956	[Effects of vasopressin on the renal water and salt excretion in rats in changing the salt concentration of drinking water and resection of kidney parenchyma].	Water	37-42	arginine vasopressin	Rattus norvegicus	12-23
13348671-0	1956	[Effects of vasopressin on the renal water and salt excretion in rats in changing the salt concentration of drinking water and resection of kidney parenchyma].	Water	117-122	arginine vasopressin	Rattus norvegicus	12-23
13350168-0	1956	[Changes in some indicators in the water-salt metabolism in the system under the effect of adrenocorticotropic hormone (ACTH)].	Water	35-40	proopiomelanocortin	Homo sapiens	91-118
13350168-0	1956	[Changes in some indicators in the water-salt metabolism in the system under the effect of adrenocorticotropic hormone (ACTH)].	Water	35-40	proopiomelanocortin	Homo sapiens	120-124
13260224-0	1955	[Heat-inactivation of crystallized catalase in different content of water].	Water	68-73	catalase	Homo sapiens	35-43
12981167-0	1952	Effect of ACTH on water distribution in man as measured by antipyrine, T 1824 and bromide.	Water	18-23	proopiomelanocortin	Homo sapiens	10-14
14921801-0	1952	The effect of ACTH on body water compartment in juvenile rheumatoid arthritis.	Water	27-32	proopiomelanocortin	Homo sapiens	14-18
14938438-0	1952	A metabolic study of a diabetic patient: the effect of variations in the dosage of insulin upon adrenal cortical activity and upon water, electrolyte and nitrogen excretion.	Water	131-136	insulin	Homo sapiens	83-90
14911983-0	1951	Solubility of bovin fibrinogen in ethanol-water mixtures.	Water	42-47	fibrinogen beta chain	Homo sapiens	20-30
14881593-0	1951	The effect of adrenocorticotropic hormone on the diuretic response to water in panhypopituitarism.	Water	70-75	proopiomelanocortin	Homo sapiens	14-41
14943493-0	1951	Total and extra cellular body water in children during ACTH treatment.	Water	30-35	proopiomelanocortin	Homo sapiens	55-59
14889626-0	1951	[Water and chloride excretion during ACTH therapy].	Water	1-6	proopiomelanocortin	Homo sapiens	37-41
18149461-0	1949	Kinetics of distribution of insulin between two body water compartments.	Water	53-58	insulin	Homo sapiens	28-35
15432747-0	1950	Effect of water-soluble vitamins on thrombin and on enzymatic inactivation of thrombin.	Water	10-15	coagulation factor II, thrombin	Homo sapiens	36-44
15432747-0	1950	Effect of water-soluble vitamins on thrombin and on enzymatic inactivation of thrombin.	Water	10-15	coagulation factor II, thrombin	Homo sapiens	78-86
19870942-2	1940	Renin reacts with renin-activator to form a strong pressor substance which is heat-stable, water- and alcohol-soluble, fluorescent, acid-stable, and alkali-labile.	Water	91-96	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	0-5
18878810-0	1948	The adsorption of water vapour on insulin and plasma albumin.	Water	18-23	insulin	Homo sapiens	34-41
19872878-5	1935	The treatment with distilled water which removes the potassium effect from the outer protoplasmic surface does not seem to affect the inner protoplasmic surface in the same way since the latter retains the outwardly directed potential which is apparently due to the potassium in the sap.	Water	29-34	SH2 domain containing 1A	Homo sapiens	283-286
17787489-0	1946	The Production of Ice Crystals in a Cloud of Supercooled Water Droplets.	Water	57-62	carboxylesterase 2	Homo sapiens	18-21
20276560-0	1946	Absorption and excretion of water; the antidiuretic hormone.	Water	28-33	arginine vasopressin	Homo sapiens	39-59
19870942-2	1940	Renin reacts with renin-activator to form a strong pressor substance which is heat-stable, water- and alcohol-soluble, fluorescent, acid-stable, and alkali-labile.	Water	91-96	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	18-23
19873130-2	1939	The rate of entrance of water into impaled cells of Halicystis Osterhoutii, Blinks and Blinks, has been determined directly by measurements of the rise of sap in a capillary for dilute sea waters (containing between 90 and 30 per cent sea water).	Water	24-29	SH2 domain containing 1A	Homo sapiens	155-158
19873130-2	1939	The rate of entrance of water into impaled cells of Halicystis Osterhoutii, Blinks and Blinks, has been determined directly by measurements of the rise of sap in a capillary for dilute sea waters (containing between 90 and 30 per cent sea water).	Water	189-194	SH2 domain containing 1A	Homo sapiens	155-158
19873131-2	1939	When cells of Halicystis are impaled on a capillary so that space is provided into which the sap can migrate, the rate of entrance of water and of electrolyte is increased about 10-fold.	Water	134-139	SH2 domain containing 1A	Homo sapiens	93-96
19872321-11	1926	Such a decrease may be brought about even when the cells are previously exposed to sea water containing HCl, in which the pH value of the sap remains normal.	Water	87-92	SH2 domain containing 1A	Homo sapiens	138-141
33933962-2	2021	The results showed that UPA group exhibited lower liquid loss and optimized texture correlated with the formed water barrier and damaged myofibrils.	Water	111-116	plasminogen activator, urokinase	Gallus gallus	24-27
19871819-16	1920	The directive effect of gravity upon the arrangement of organs disappears in this case since the abundance of the outside water makes the effect of a slight difference in the distribution of sap between the upper and lower side a negligible factor.	Water	122-127	SH2 domain containing 1A	Homo sapiens	65-68
33756319-3	2021	As suggested by low-field NMR and magnetic resonance imaging, FGG-treated seabass presented higher water holding capacity by controlling transformation from immobilised to free water.	Water	99-104	fibrinogen gamma chain	Homo sapiens	62-65
33714114-5	2021	The structure of pasta prepared with process B was more homogeneous, whereas it was more compact in the case of process A, as shown by a lower starch susceptibility to alpha-amylase hydrolysis, higher beginning of gelatinization temperature and lower water absorption.	Water	251-256	solute carrier family 45 member 1	Homo sapiens	17-22
33756319-3	2021	As suggested by low-field NMR and magnetic resonance imaging, FGG-treated seabass presented higher water holding capacity by controlling transformation from immobilised to free water.	Water	177-182	fibrinogen gamma chain	Homo sapiens	62-65
33735773-0	2021	Identification of water-soluble peptides in distilled spent grain and its angiotensin converting enzyme (ACE) inhibitory activity based on UPLC-Q-TOF-MS and proteomics analysis.	Water	18-23	angiotensin I converting enzyme	Homo sapiens	74-103
33966843-1	2021	The goal of the study was to evaluate the influence of the solvent properties on the crystal characteristics of beta-cyclodextrin (beta-CD) recrystallized from alcohol-water solvent mixtures, with possible applications for the preparation, purifying and complexation of beta-CD.	Water	168-173	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	131-138
33735773-0	2021	Identification of water-soluble peptides in distilled spent grain and its angiotensin converting enzyme (ACE) inhibitory activity based on UPLC-Q-TOF-MS and proteomics analysis.	Water	18-23	angiotensin I converting enzyme	Homo sapiens	105-108
33966843-3	2021	Recrystallized beta-CD from water and C1-C4 alcohol-water solutions provide beta-CD with higher CI values of 99.4(+-5.9)% for ethanol-water (1:4, v/v) as recrystallizing system.	Water	28-33	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	15-22
33966843-3	2021	Recrystallized beta-CD from water and C1-C4 alcohol-water solutions provide beta-CD with higher CI values of 99.4(+-5.9)% for ethanol-water (1:4, v/v) as recrystallizing system.	Water	52-57	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	76-83
33966843-3	2021	Recrystallized beta-CD from water and C1-C4 alcohol-water solutions provide beta-CD with higher CI values of 99.4(+-5.9)% for ethanol-water (1:4, v/v) as recrystallizing system.	Water	52-57	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	76-83
33721645-4	2021	Among them, sul1, sul2 and int1 were the dominant target genes in water samples.	Water	66-71	Wnt family member 1	Homo sapiens	27-31
33743462-5	2021	The simulated pattern of NO3- release to the surface water receptor occurred approximately 8 years before its measured arrival.	Water	53-58	NBL1, DAN family BMP antagonist	Homo sapiens	25-28
33677279-7	2021	AnMBR was able to produce permeate water with an average COD of 51 +- 8 mg L-1 at an HRT of 2 d during the summer period with an average temperature of 24  C. The effluent COD increased to 67 +- 10 mg L-1 and reached 91 +- 5 mg L-1 for HRT 1 d and 12 h respectively for the same temperature range.	Water	35-40	L1 cell adhesion molecule	Homo sapiens	201-231
33689891-1	2021	This paper investigates the impacts of extensive riverbed mining in the Lower Mekong on the water level, extent and volume of the Tonle Sap Lake, the largest freshwater lake in Southeast Asia.	Water	92-97	SH2 domain containing 1A	Homo sapiens	136-139
33689891-5	2021	A hysteretic relationship between water levels at Prek Kdam and Tonle Sap indicates that Tonle Sap"s water level is largely controlled by Tonle Sap River and the Mekong, and declining water levels at Prek Kdam due to extensive sand mining in Phnom Penh is directly related to the shrinking of the lake.	Water	34-39	SH2 domain containing 1A	Homo sapiens	70-73
33689891-5	2021	A hysteretic relationship between water levels at Prek Kdam and Tonle Sap indicates that Tonle Sap"s water level is largely controlled by Tonle Sap River and the Mekong, and declining water levels at Prek Kdam due to extensive sand mining in Phnom Penh is directly related to the shrinking of the lake.	Water	34-39	SH2 domain containing 1A	Homo sapiens	95-98
33689891-5	2021	A hysteretic relationship between water levels at Prek Kdam and Tonle Sap indicates that Tonle Sap"s water level is largely controlled by Tonle Sap River and the Mekong, and declining water levels at Prek Kdam due to extensive sand mining in Phnom Penh is directly related to the shrinking of the lake.	Water	34-39	SH2 domain containing 1A	Homo sapiens	95-98
33689891-5	2021	A hysteretic relationship between water levels at Prek Kdam and Tonle Sap indicates that Tonle Sap"s water level is largely controlled by Tonle Sap River and the Mekong, and declining water levels at Prek Kdam due to extensive sand mining in Phnom Penh is directly related to the shrinking of the lake.	Water	101-106	SH2 domain containing 1A	Homo sapiens	70-73
33689891-5	2021	A hysteretic relationship between water levels at Prek Kdam and Tonle Sap indicates that Tonle Sap"s water level is largely controlled by Tonle Sap River and the Mekong, and declining water levels at Prek Kdam due to extensive sand mining in Phnom Penh is directly related to the shrinking of the lake.	Water	101-106	SH2 domain containing 1A	Homo sapiens	95-98
33689891-5	2021	A hysteretic relationship between water levels at Prek Kdam and Tonle Sap indicates that Tonle Sap"s water level is largely controlled by Tonle Sap River and the Mekong, and declining water levels at Prek Kdam due to extensive sand mining in Phnom Penh is directly related to the shrinking of the lake.	Water	101-106	SH2 domain containing 1A	Homo sapiens	95-98
33689891-5	2021	A hysteretic relationship between water levels at Prek Kdam and Tonle Sap indicates that Tonle Sap"s water level is largely controlled by Tonle Sap River and the Mekong, and declining water levels at Prek Kdam due to extensive sand mining in Phnom Penh is directly related to the shrinking of the lake.	Water	101-106	SH2 domain containing 1A	Homo sapiens	70-73
33689891-5	2021	A hysteretic relationship between water levels at Prek Kdam and Tonle Sap indicates that Tonle Sap"s water level is largely controlled by Tonle Sap River and the Mekong, and declining water levels at Prek Kdam due to extensive sand mining in Phnom Penh is directly related to the shrinking of the lake.	Water	101-106	SH2 domain containing 1A	Homo sapiens	95-98
33689891-5	2021	A hysteretic relationship between water levels at Prek Kdam and Tonle Sap indicates that Tonle Sap"s water level is largely controlled by Tonle Sap River and the Mekong, and declining water levels at Prek Kdam due to extensive sand mining in Phnom Penh is directly related to the shrinking of the lake.	Water	101-106	SH2 domain containing 1A	Homo sapiens	95-98
33677279-7	2021	AnMBR was able to produce permeate water with an average COD of 51 +- 8 mg L-1 at an HRT of 2 d during the summer period with an average temperature of 24  C. The effluent COD increased to 67 +- 10 mg L-1 and reached 91 +- 5 mg L-1 for HRT 1 d and 12 h respectively for the same temperature range.	Water	35-40	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	236-241
34036382-9	2021	The Txk-knockdown lentivirus resulted in decreased brain infarct volume, neurological score, brain water content, apoptosis and oxidative stress after MCAO in vivo.	Water	99-104	TXK tyrosine kinase	Rattus norvegicus	4-7
33858580-3	2021	Based on the water insolubility of C9-PVA and the inclusion ability of alpha-CD for alkyl groups, alpha-CD/C9-PVA ICF was prepared.	Water	13-18	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	98-106
33858580-5	2021	Furthermore, alpha-CD/2.5C9-PVA (w/w = 0.5) ICF had better water vapor transmission rate than that of commercial tapes.	Water	59-64	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	13-23
19872676-15	1932	The formation of KA and NaA in the sap raises its osmotic pressure and water enters.	Water	71-76	SH2 domain containing 1A	Homo sapiens	35-38
19872676-20	1932	No equilibrium occurs but a steady state is reached in which water and salt enter at the same rate so that the composition of the sap remains constant as its volume increases.	Water	61-66	SH2 domain containing 1A	Homo sapiens	130-133
33827023-8	2021	The findings highlight that communities with as much as 100 cap ha-1, typical of urban peripheries, could have their pollutant load reduced to about half if the pipe length per capita is 5 m. It was seen in this study that while the collection system supports wastewater management by functioning to collect and transport wastewater, it can further be elevated into a treatment technology within appropriate localities and thus, contribute to a circular water economy.	Water	265-270	Rho GTPase activating protein 45	Homo sapiens	64-68
33848722-1	2021	A focused library of water soluble 1,2,3-triazole tethered glycopeptide conjugates derived from variety of azido-monosaccharides and aliphatic azido-alcohols were synthesized through manipulation at the C-terminus of Pam3CAG and screened for their potential as TLR2 agonistic adjuvants against HBsAg antigen.	Water	21-26	toll like receptor 2	Homo sapiens	261-265
33453669-0	2021	Low-cost hydrogel adsorbent enhanced by trihydroxy melamine and beta-cyclodextrin for the removal of Pb(II) and Ni(II) in water.	Water	122-127	submaxillary gland androgen regulated protein 3B	Homo sapiens	101-107
33453669-4	2021	The Langmuir isotherm model showed that the adsorption capacity of the hydrogel for Pb(II) and Ni(II) reached 505.9 mg/g and 286.7 mg/g, respectively, and the efficiency of removing the low-concentration heavy metal ions in water more than 99%.	Water	224-229	submaxillary gland androgen regulated protein 3B	Homo sapiens	84-90
33951863-4	2021	The dynamics simulation results showed that APG-12 molecules can be easily adsorbed on the surface of coal molecules and then adsorb water molecules around them under the action of hydrogen bonds.	Water	133-138	autophagy related 12	Homo sapiens	44-50
33962237-4	2021	The long-distance, open-channel South-to-North water diversion increased PFAS contamination risk.	Water	47-52	phosphoribosylformylglycinamidine synthase	Homo sapiens	73-77
33962237-7	2021	In loop-structured DWDSs, finished water with different PFAS characteristics could mix along the pipeline, with the corresponding DWTP as the center, ultimately forming a relatively uniform distribution in the entire DWDS.	Water	35-40	phosphoribosylformylglycinamidine synthase	Homo sapiens	56-60
33540329-0	2021	Chia seed-assisted separation and detection of polyvinyl chloride microplastics in water via gas chromatography mass spectrometry.	Water	83-88	chitinase acidic	Homo sapiens	0-4
33988981-7	2021	For the first time, we present a cocrystal structure of SAMHD1 with a substrate, Rp-dGTPalphaS, in which an Fe-Mg-bridging water species is poised for nucleophilic attack on the Palpha.	Water	123-128	ultraconserved element uc.328	Homo sapiens	87-93
33540329-1	2021	Chia seeds were used to significantly improve the separation efficiency of polyvinyl chloride (PVC) microplastics from water samples via centrifugation.	Water	119-124	chitinase acidic	Homo sapiens	0-4
33740634-3	2021	Bovine serum albumin (BSA) is a natural, non-toxic protein with high water-solubility and low immunogenicity, and is widely used as a nanocarrier for targeted drug delivery.	Water	69-74	albumin	Homo sapiens	7-20
33964507-2	2021	This work presents an eco-friendly surface modification strategy to functionalize hydrophilic cellulose nanocrystals (CNC) using hydrophobic soy protein isolate (SPI) via mussel adhesive-inspired poly (l-dopa) (PLD) to develop improved nanoconjugates as stabilizers for oil-in-water Pickering emulsion.	Water	277-282	chromogranin A	Homo sapiens	162-165
34000801-0	2021	Historical Changes in Seasonal Aerosol Acidity in the Po Valley (Italy) as Inferred from Fog Water and Aerosol Measurements.	Water	93-98	zinc finger protein, FOG family member 1	Homo sapiens	89-92
34000801-5	2021	Applying the new method to historical (25 years) fog water composition at the rural station of San Pietro Capofiume (SPC) in the Po Valley (Italy) suggests that the aerosol has been mildly acidic, with its pH decreasing by 0.5-1.5 pH units over the last decades.	Water	53-58	zinc finger protein, FOG family member 1	Homo sapiens	49-52
34000801-6	2021	The observed pH of the fog water also increased 1 unit over the same period.	Water	27-32	zinc finger protein, FOG family member 1	Homo sapiens	23-26
33647630-4	2021	The initial relaxation time of T2b, T21, and T22 decreased when SPI increased; meanwhile, the peak ratio of P21 increased significantly (P < 0.05), implying that water had lower mobility.	Water	162-167	chromogranin A	Homo sapiens	64-67
34053538-3	2021	Herein, we extracted a polysaccharide fraction (GEP) from Gastrodia elata by water extraction and alcohol precipitation and aimed to reveal its oral absorption processes through animal models and Caco-2 cells monolayer models.	Water	77-82	granulin precursor	Homo sapiens	48-51
33647630-5	2021	Overall, the 2% SPI could enhance gel characteristics and water-holding capacity of pork myofibrillar protein under 200 MPa.	Water	58-63	chromogranin A	Homo sapiens	16-19
33382180-3	2021	The expression of key genes in colonic MCs and their relationship with CGRP-containing fibers were examined by immunofluorescence in chronic water-avoidance stress (WAS)-induced visceral hyperalgesia mice.	Water	141-146	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	71-75
33960375-8	2021	D560N/R468K MBD4 bound to T:G mismatched DNA shows that the side chain amine moiety of the Lys stabilizes the flipped-out thymine by a water-mediated phosphate pinching, while the backbone carbonyl oxygen of the Lys engages in hydrogen bonds with N2 of the estranged guanine.	Water	135-140	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	12-16
33548702-0	2021	A year-long cyclic pattern of dissolved organic matter in the tap water of a metropolitan city revealed by fluorescence spectroscopy.	Water	66-71	SEC14 like lipid binding 2	Homo sapiens	62-65
33548702-2	2021	This study investigated the year-long dynamics of dissolved organic matter (DOM) in the tap water and source water of a metropolitan city in southern China using fluorescence spectroscopy.	Water	92-97	SEC14 like lipid binding 2	Homo sapiens	88-91
33548702-3	2021	The DOM detected in the tap water, and source water of Shenzhen city was season and location-dependent.	Water	28-33	SEC14 like lipid binding 2	Homo sapiens	24-27
33629353-8	2021	PdGNC activates PdHXK1 (a hexokinase synthesis key gene), resulting in a remarkable increase in hexokinase activity in poplars subjected to water deficit.	Water	140-145	hexokinase 1	Homo sapiens	26-36
33629353-8	2021	PdGNC activates PdHXK1 (a hexokinase synthesis key gene), resulting in a remarkable increase in hexokinase activity in poplars subjected to water deficit.	Water	140-145	hexokinase 1	Homo sapiens	96-106
33736577-5	2021	Therefore, in the present study, film dosage forms containing ET were produced using water-soluble polymers and glycerin (GLY) as excipients to obtain a practical buccal dosage form.	Water	85-90	major facilitator superfamily domain containing 11	Homo sapiens	62-64
33540164-6	2021	Moreover, the degradation of BP-1 in five water matrices was also compared, and the removal rates followed the order of ultrapure water > tap water > secondary clarifier effluent > river water > synthetic water.	Water	42-47	BP1	Homo sapiens	29-33
33540164-6	2021	Moreover, the degradation of BP-1 in five water matrices was also compared, and the removal rates followed the order of ultrapure water > tap water > secondary clarifier effluent > river water > synthetic water.	Water	130-135	BP1	Homo sapiens	29-33
33540164-6	2021	Moreover, the degradation of BP-1 in five water matrices was also compared, and the removal rates followed the order of ultrapure water > tap water > secondary clarifier effluent > river water > synthetic water.	Water	130-135	BP1	Homo sapiens	29-33
33540164-6	2021	Moreover, the degradation of BP-1 in five water matrices was also compared, and the removal rates followed the order of ultrapure water > tap water > secondary clarifier effluent > river water > synthetic water.	Water	130-135	BP1	Homo sapiens	29-33
33540164-6	2021	Moreover, the degradation of BP-1 in five water matrices was also compared, and the removal rates followed the order of ultrapure water > tap water > secondary clarifier effluent > river water > synthetic water.	Water	130-135	BP1	Homo sapiens	29-33
33540164-10	2021	The present work illustrates that BP-1 could be efficiently degraded in the Fe0/PS system, which may provide new insights into the removal of benzophenones in water and wastewater.	Water	159-164	BP1	Homo sapiens	34-38
33836297-0	2021	Ferrate Self-Decomposition in Water Is Also a Self-Activation Process: Role of Fe(V) Species and Enhancement with Fe(III) in Methyl Phenyl Sulfoxide Oxidation by Excess Ferrate.	Water	30-35	FEV transcription factor, ETS family member	Homo sapiens	79-84
34058321-3	2021	When ordinary metabolism is upset by extraordinary events such as injury, pathogenic infection, air or water pollution, ingestion of toxins, or simply by the slow but incessant changes brought about by aging and genetic variations, Nrf2 may also be called into action by the redox changes resulting from these events, whether acute or chronic.	Water	103-108	NFE2 like bZIP transcription factor 2	Homo sapiens	232-236
34034251-1	2021	BACKGROUND: Angiotensin II (Ang II) and the renal sympathetic nervous system exert a strong influence on renal sodium and water excretion.	Water	122-127	angiotensinogen	Rattus norvegicus	12-26
34042424-2	2021	Janus membrane, as a highly efficient method to collect the invisible fog water in the wet environment, is still hindered by some inherent limitations: (1) poor condensation of fog droplets on the superhydrophobic side due to the ultralow adhesive force of droplets with substrate and (2) insufficient detachment of droplets from the superhydrophilic side in time, which hampers the continuous water transport in the micropores.	Water	74-79	zinc finger protein, FOG family member 1	Homo sapiens	70-73
34041783-10	2021	BBB permeability to water was found to be related to AD markers of CSF Abeta and ptau.	Water	20-25	amyloid beta precursor protein	Homo sapiens	71-76
34039987-2	2021	A well-known feature of its phase diagram is that high-temperature phases of ice with orientational disorder of the hydrogen-bonded water molecules undergo phase transitions to their ordered counterparts upon cooling.	Water	132-137	carboxylesterase 2	Homo sapiens	77-80
34037327-2	2021	OBJECTIVES: The present proof-of-principle study assessed whether daily use of a power-driven water flosser (Sonicare AirFloss; SAF) leads to bacterial colonization in the nozzle and/or the device, resulting in contaminated water-jet.	Water	94-99	FAS antisense RNA 1	Homo sapiens	128-131
34037327-2	2021	OBJECTIVES: The present proof-of-principle study assessed whether daily use of a power-driven water flosser (Sonicare AirFloss; SAF) leads to bacterial colonization in the nozzle and/or the device, resulting in contaminated water-jet.	Water	224-229	FAS antisense RNA 1	Homo sapiens	128-131
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	Water	41-44	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	Water	41-44	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	Water	41-44	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	172-176
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	Water	41-44	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	177-181
33900735-0	2021	Surface Potential Driven Water Harvesting from Fog.	Water	25-30	zinc finger protein, FOG family member 1	Homo sapiens	47-50
33900735-1	2021	Access to clean water is a global challenge, and fog collectors are a promising solution.	Water	16-21	zinc finger protein, FOG family member 1	Homo sapiens	49-52
33900735-4	2021	We experimentally measured the effect of both the surface morphology and the chemistry of PC fiber on their surface potential and mechanical properties in relation to the water collection efficiency from fog.	Water	171-176	zinc finger protein, FOG family member 1	Homo sapiens	204-207
34034251-1	2021	BACKGROUND: Angiotensin II (Ang II) and the renal sympathetic nervous system exert a strong influence on renal sodium and water excretion.	Water	122-127	angiotensinogen	Rattus norvegicus	28-34
34036349-9	2021	In these compartments, the water content was significantly higher in patients with POMC and MC4R mutation than in control-groups.	Water	27-32	proopiomelanocortin	Homo sapiens	83-87
33979522-4	2021	The present diffraction data permits, for the first time, the accurate determination of the bulk moduli B0 of 225 (or 228) GPa for ice X and 6.2 (or 4.5) GPa for ice VII, in H2O-H2 (or H2O-He), which can provide new constraints for Giant planetary models.	Water	174-177	glycophorin A (MNS blood group)	Homo sapiens	123-126
34011099-1	2021	ABSTRACT: Increased water intake correlated to lower vasopressin level and may benefit kidney function.	Water	20-25	arginine vasopressin	Homo sapiens	53-64
34009624-0	2021	Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment.	Water	148-153	ATP binding cassette subfamily B member 1	Homo sapiens	43-57
34022315-3	2021	Inspired by the unique conformational behavior of lysozyme proteins in water-ethanol mixtures, we conducted quartz crystal microbalance-dissipation (QCM-D) and localized surface plasmon resonance (LSPR) measurements to systematically investigate the adsorption behavior of lysozyme proteins onto silica surfaces across a wide range of water-ethanol mixtures.	Water	71-76	lysozyme	Homo sapiens	50-58
34022315-4	2021	Our findings revealed that lysozyme adsorption behavior strongly depended on the ethanol fraction in a non-monotonic fashion and this trend could be rationalized by taking into account how competing effects of water and ethanol solvation influence solution-phase protein size and conformational stability.	Water	210-215	lysozyme	Homo sapiens	27-35
33961416-3	2021	However, using nonequilibrium molecular dynamics simulations, in which an amyloid-beta amyloid fibril was destroyed via infrared free-electron laser (IR-FEL) irradiation, we discovered a new mechanism, in which water molecules disrupt protein aggregates.	Water	211-216	amyloid beta precursor protein	Homo sapiens	74-86
33979522-3	2021	Here, we present well-resolved X-ray diffraction data of H2O in quasi-hydrostatic H2 and He pressure media, clearly resolving the two ice phases to 130 GPa and the dissociative nature of ice VII to X transition occurring at 20-50 GPa in H2O-H2 and 60-70 GPa in H2O-He.	Water	57-60	glycophorin A (MNS blood group)	Homo sapiens	152-155
33979522-3	2021	Here, we present well-resolved X-ray diffraction data of H2O in quasi-hydrostatic H2 and He pressure media, clearly resolving the two ice phases to 130 GPa and the dissociative nature of ice VII to X transition occurring at 20-50 GPa in H2O-H2 and 60-70 GPa in H2O-He.	Water	57-60	glycophorin A (MNS blood group)	Homo sapiens	230-233
33979522-3	2021	Here, we present well-resolved X-ray diffraction data of H2O in quasi-hydrostatic H2 and He pressure media, clearly resolving the two ice phases to 130 GPa and the dissociative nature of ice VII to X transition occurring at 20-50 GPa in H2O-H2 and 60-70 GPa in H2O-He.	Water	57-60	glycophorin A (MNS blood group)	Homo sapiens	230-233
34017100-4	2021	We report a class of biomimetic, helically folded pore-forming polymeric foldamers that can serve as long-sought-after highly selective ultrafast water-conducting channels with performance exceeding those of AQPs (1.1 x 1010 water molecules per second for AQP1), with high water-over-monovalent-ion transport selectivity (~108 water molecules over Cl- ion) conferred by the modularly tunable hydrophobicity of the interior pore surface.	Water	146-151	aquaporin 1 (Colton blood group)	Homo sapiens	256-260
34017100-4	2021	We report a class of biomimetic, helically folded pore-forming polymeric foldamers that can serve as long-sought-after highly selective ultrafast water-conducting channels with performance exceeding those of AQPs (1.1 x 1010 water molecules per second for AQP1), with high water-over-monovalent-ion transport selectivity (~108 water molecules over Cl- ion) conferred by the modularly tunable hydrophobicity of the interior pore surface.	Water	225-230	aquaporin 1 (Colton blood group)	Homo sapiens	256-260
34017100-4	2021	We report a class of biomimetic, helically folded pore-forming polymeric foldamers that can serve as long-sought-after highly selective ultrafast water-conducting channels with performance exceeding those of AQPs (1.1 x 1010 water molecules per second for AQP1), with high water-over-monovalent-ion transport selectivity (~108 water molecules over Cl- ion) conferred by the modularly tunable hydrophobicity of the interior pore surface.	Water	225-230	aquaporin 1 (Colton blood group)	Homo sapiens	256-260
34017100-4	2021	We report a class of biomimetic, helically folded pore-forming polymeric foldamers that can serve as long-sought-after highly selective ultrafast water-conducting channels with performance exceeding those of AQPs (1.1 x 1010 water molecules per second for AQP1), with high water-over-monovalent-ion transport selectivity (~108 water molecules over Cl- ion) conferred by the modularly tunable hydrophobicity of the interior pore surface.	Water	225-230	aquaporin 1 (Colton blood group)	Homo sapiens	256-260
34017100-5	2021	The best-performing AWC reported here delivers water transport at an exceptionally high rate, namely, 2.5 times that of AQP1, while concurrently rejecting salts (NaCl and KCl) and even protons.	Water	47-52	aquaporin 1 (Colton blood group)	Homo sapiens	120-124
34009624-1	2021	PURPOSE: The purpose of this research is to analyze non-linear pharmacokinetics of P-glycoprotein (P-gp) substrates in a cell based assay of a microfluidic device, which might be affected by hydrodynamic barrier (unstirred water layer, UWL).	Water	223-228	ATP binding cassette subfamily B member 1	Homo sapiens	83-97
34009624-1	2021	PURPOSE: The purpose of this research is to analyze non-linear pharmacokinetics of P-glycoprotein (P-gp) substrates in a cell based assay of a microfluidic device, which might be affected by hydrodynamic barrier (unstirred water layer, UWL).	Water	223-228	ATP binding cassette subfamily B member 1	Homo sapiens	99-103
34001853-4	2021	In addition, catalase expression was also reduced in CLL cells suggesting impairment of H2O2-conversion into water and O2 which may cause H2O2-accumulation.	Water	109-114	catalase	Homo sapiens	13-21
33272752-5	2021	A plummeting effect was only observed in water media after 27 kJ/cm3 by FRAP (47  C) and DPPH (86  C) antioxidant activities, indicating that the presence of solutes (citric acid and NaCl) after 27 kJ/cm3 reduced degradation of flavonoids.	Water	41-46	mechanistic target of rapamycin kinase	Homo sapiens	72-76
34000028-0	2021	Neurons and Astrocytes in Ventrolateral Periaqueductal Gray Contribute to Restraint Water Immersion Stress-induced Gastric Mucosal Damage via the ERK1/2 Signaling Pathway.	Water	84-89	mitogen-activated protein kinase 3	Homo sapiens	146-152
33990323-1	2021	Ice-sheet responses to climate warming and associated sea-level rise depend sensitively on the form of the slip law that relates drag at the beds of glaciers to their slip velocity and basal water pressure.	Water	191-196	carboxylesterase 2	Homo sapiens	0-3
33781883-7	2021	The water probe demonstrates an average interaction energy of -6.48 kcal/mol on the 002 plane of BGN-4AM, and only -5.47 kcal/mol on the 011 plane of BGN monohydrate.	Water	4-9	biglycan	Homo sapiens	97-100
33486175-11	2021	This incongruous water clarity effect, the spatial extent of which is defined here as an Organic Fog Zone, was present in February to April in all years studied, but occurred farther south in wet years.	Water	17-22	zinc finger protein, FOG family member 1	Homo sapiens	97-100
33881025-6	2021	Moreover, the stability and practical applications of Co/N-CNTs towards Pb(ii) in real water samples obtained from a mining subsidence area were also considered.	Water	87-92	submaxillary gland androgen regulated protein 3B	Homo sapiens	72-78
33990601-1	2021	Solar steam water purification and fog collection are two independent processes that could enable abundant fresh water generation.	Water	113-118	zinc finger protein, FOG family member 1	Homo sapiens	35-38
33239488-8	2021	Furthermore, both propolis and diclofenac sodium significantly attenuated the lambda-carrageenan-induced increase in the protein expression levels of the pro-inflammatory cytokine TNF-alpha depicting more than two-fold decrement relative to the distilled water group.	Water	255-260	tumor necrosis factor	Mus musculus	180-189
33947181-5	2021	Thus, the combination of the CS2 model of DMF and the TIP4P/2005 water model reproduces the properties of the DMF-water mixtures far better than the other combinations tested.	Water	114-119	chorionic somatomammotropin hormone 2	Homo sapiens	29-32
33990498-19	2021	CONCLUSION: Aquaporin8 is a water channel selectively expressed in normal colon tissue.	Water	28-33	aquaporin 8	Homo sapiens	12-22
33983359-4	2021	The subsequent near infrared (NIR) light irradiation at 980 nm or visible light irradiation at 470 nm can initiate dissociation of the spc ligand, and the released Ru(ii) aqua compounds ([Ru(dip)2(H2O)2]2+) may exert a potent cytotoxicity towards a series of cancer cells but a much weaker effect on the normal IOSE80 cells.	Water	197-200	surfactant protein C	Homo sapiens	135-138
33980833-5	2021	In this study, we determine that the magnetic anisotropy of a Co(II) complex can be effectively controlled by the slight rotation of coordinating water ligands, which is achieved by a two-step structural phase transition.	Water	146-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
33980862-2	2021	In TNBC, Aquaporin 1 (AQP1), a water-transporting transmembrane protein, is aberrantly enriched in cytoplasm and causes tumor cell death evasion.	Water	31-36	aquaporin 1 (Colton blood group)	Homo sapiens	9-20
33978290-0	2021	Low amounts of heavy water increase the phase separation propensity of a fragment of the androgen receptor activation domain.	Water	21-26	androgen receptor	Homo sapiens	89-106
33980862-2	2021	In TNBC, Aquaporin 1 (AQP1), a water-transporting transmembrane protein, is aberrantly enriched in cytoplasm and causes tumor cell death evasion.	Water	31-36	aquaporin 1 (Colton blood group)	Homo sapiens	22-26
34020268-5	2021	By attaching a polyethylene glycol (PEG) chain onto AIEPS5, the yielded amphiphilic AIEPS5-PEG2000 can spontaneously self-assemble into water dispersible NPs, which are further endowed with targeted delivery function via the decoration of anti-Her-2 nanobody (NB).	Water	136-141	erb-b2 receptor tyrosine kinase 2	Homo sapiens	244-249
33969745-5	2021	Here, we report that heavy water lengthened the rhythm period of clock gene expression of the SCN and peripheral tissues in vitro using a PERIOD2::LUCIFERASE bioluminescence reporter.	Water	27-32	period circadian clock 2	Mus musculus	138-145
33835819-0	2021	Phase Equilibrium of Water with Hexagonal and Cubic Ice Using the SCAN Functional.	Water	21-26	carboxylesterase 2	Homo sapiens	52-55
33508367-0	2021	Anti-inflammatory activity of the water extract of Chloranthus serratus roots in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-kappaB signaling pathways.	Water	34-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	127-131
33508367-0	2021	Anti-inflammatory activity of the water extract of Chloranthus serratus roots in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-kappaB signaling pathways.	Water	34-39	heme oxygenase 1	Mus musculus	132-136
33508367-0	2021	Anti-inflammatory activity of the water extract of Chloranthus serratus roots in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-kappaB signaling pathways.	Water	34-39	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	147-156
34023711-0	2021	Endopeptidases, exopeptidases, and glutamate decarboxylase in soybean water extract and their in vitro activity.	Water	70-75	glutamate decarboxylase	Glycine max	35-58
34023711-2	2021	Herein, 16 endopeptidases, 13 exopeptidases, 24 inhibitors (two serpin-ZX and one subtilisin inhibitor firstly identified), and one glutamate decarboxylase were identified in the soybean water extract by the liquid chromatography tandem mass spectrometry analysis.	Water	187-192	glutamate decarboxylase	Glycine max	132-155
33955988-3	2021	Under the optimal conditions, differential pulse voltammetry shows that the peak current ratio (Id/Il) of Trp enantiomers can reach 2.84 at 15  C. More interestingly, the beta-CD@PEI-Fc/GCE exhibited chiral recognition of d-Trp and l-Trp via water contact angle measurements.	Water	242-247	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	171-178
33960049-7	2021	Among of three photosensitizers, TPP-PPh3-4PEG is the most efficient (singlet oxygen yield: 0.89) for tumour photodynamic therapy not only because of its definite constituent, but also because its amphiphilic structure allows it to self-assemble in water.	Water	249-254	caveolin 1	Homo sapiens	37-41
33965460-3	2021	Short and water-soluble SAP biomaterials associated with enhanced pharmacokinetic (PK) and pharmacodynamic (PD) responses after the topical administration of the therapeutic systems, or improved regenerative potential in tissue engineering applications will be the focus of the current review.	Water	10-15	SH2 domain containing 1A	Homo sapiens	24-27
33248826-0	2021	Removal of As(V) from water using galvanically coupled sacrificial metals.	Water	22-27	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	11-16
33984806-7	2021	These results emphasized that the application of cation-pi interactions by introducing basic aliphatic amine moiety is beneficial for both the water solubility and the NQO1-substrate binding, leading to promising NQO1-targeting antitumor candidates with improved druglike properties.	Water	143-148	NAD(P)H quinone dehydrogenase 1	Homo sapiens	213-217
33904544-7	2021	The UV-vis absorbance of CoII further corroborates TX-100-assisted water pool formation within TBAC-DA via the appearance of the band that is assigned to the response of the probe in water.	Water	67-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
33904544-7	2021	The UV-vis absorbance of CoII further corroborates TX-100-assisted water pool formation within TBAC-DA via the appearance of the band that is assigned to the response of the probe in water.	Water	183-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
33952296-0	2021	Seasonal rhythms of vasopressin release and aquaporin-2 excretion assure appropriate water conservation in humans.	Water	85-90	arginine vasopressin	Homo sapiens	20-31
33949526-3	2021	The Re-thiosulfate complex in 2 was characterized in two solvated crystal structures {Na(fac-[Re(CO)3(bpy)(S2O3)]) 1.75H2O C2H5OH}4 (2 + 0.75H2O + C2H5OH)4 and (fac-[Re(CO)3(bpy)(H2O)]) (fac-[Re(CO)3(bpy)(S2O3)]) 4H2O (3).	Water	119-122	FA complementation group C	Homo sapiens	89-92
33949526-2	2021	Here, we compare the cytotoxicity and cellular uptake of two Re(i) compounds fac-[(Re(CO)3(bpy)(H2O)](CF3SO3) (1) and Na(fac-[(Re(CO)3(bpy)(S2O3)]) H2O (bpy = 2,2"-bipyridine) (2).	Water	96-99	FA complementation group C	Homo sapiens	77-80
33545379-7	2021	The results also showed that serum Ngb levels were independently negatively correlated with arsenic concentration in drinking water.	Water	126-131	neuroglobin	Rattus norvegicus	35-38
33586018-3	2021	This microbleed evolution is suggestive of water-soluble amyloid-beta transmission via cerebrospinal fluid alongside perivascular drainage pathways with deposition in the cerebral artery walls due to clearance disturbances.	Water	43-48	amyloid beta precursor protein	Homo sapiens	57-69
33660401-4	2021	AKAPs such as AKAP18, AKAP220, AKAP-Lbc and STUB1, and PDE4 coordinate arginine-vasopressin (AVP)-induced water reabsorption by collecting duct principal cells.	Water	106-111	A-kinase anchoring protein 13	Homo sapiens	31-39
33660401-4	2021	AKAPs such as AKAP18, AKAP220, AKAP-Lbc and STUB1, and PDE4 coordinate arginine-vasopressin (AVP)-induced water reabsorption by collecting duct principal cells.	Water	106-111	phosphodiesterase 4A	Homo sapiens	55-59
33660401-4	2021	AKAPs such as AKAP18, AKAP220, AKAP-Lbc and STUB1, and PDE4 coordinate arginine-vasopressin (AVP)-induced water reabsorption by collecting duct principal cells.	Water	106-111	arginine vasopressin	Homo sapiens	71-91
33660401-4	2021	AKAPs such as AKAP18, AKAP220, AKAP-Lbc and STUB1, and PDE4 coordinate arginine-vasopressin (AVP)-induced water reabsorption by collecting duct principal cells.	Water	106-111	arginine vasopressin	Homo sapiens	93-96
33780670-6	2021	This is all in a bid to understand the imminent dangers of the contamination of water bodies with pharmaceutical products and how this process unfavorably affects aquatic food webs.	Water	80-85	BH3 interacting domain death agonist	Homo sapiens	17-20
33188513-0	2021	Appraisal of water matrix on the removal of fungicide residues by heterogeneous photocatalytic treatment using UV-LED lamp as light source.	Water	13-18	small integral membrane protein 10 like 2A	Homo sapiens	114-117
33188513-6	2021	Results showed that UV-LED are a suitable alternative for tackling the removal of organic pollutants in water.	Water	104-109	small integral membrane protein 10 like 2A	Homo sapiens	23-26
33947926-12	2021	Considering that they are pharmaceutically active and resistant to treatment processes within an STP, it is advised that a regular monitoring and management program for PDE-5i should be developed to prevent the discharge of the pharmaceuticals into the water environment.	Water	253-258	phosphodiesterase 5A	Homo sapiens	169-174
33388500-5	2021	Once the PMM was charged at -1 V as a membrane electrode, the normalized water flux was maintained at 92.48 +- 1.14% after fouling by bovine serum albumin (BSA) solutions, which was 18.82% higher than that when the PMM was not charged.	Water	73-78	albumin	Homo sapiens	141-154
33199118-1	2021	Pasta is mostly composed by wheat flour and water.	Water	44-49	solute carrier family 45 member 1	Homo sapiens	0-5
33736588-7	2021	Extravascular lung water was correlated with total, conjugated, and unconjugated bilirubin and albumin (r = 0.342/P = .005; r = 0.338/ P = .005; r = 0.394/P = .001, and r = 0.358/P = .003) but not with aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and serum creatinine.	Water	19-24	albumin	Homo sapiens	95-102
33558997-0	2021	Experimental and theoretical investigation of water-soluble silicon(IV) phthalocyanine and its interaction with bovine serum albumin.	Water	46-51	albumin	Homo sapiens	119-132
32965038-8	2021	At the behavioral level, after three weeks of treatment, the anti-Lingo-1 group rats displayed significantly more platform location crossings in the Morris water maze test than the chronic stress group rats.	Water	156-161	leucine rich repeat and Ig domain containing 1	Rattus norvegicus	66-73
33635498-1	2021	A Schiff-base 2-((E)-(3-(prop-1-en-2-yl)phenylimino)methyl)-4-nitrophenol (Receptor 1) colorimetric probe was synthesized and its UV-visible and fluorescence spectral properties for the sensing of Cu+ 2 ions in CH3OH/H2O (60:40,v/v) solvent system was explored.	Water	217-220	PROP paired-like homeobox 1	Homo sapiens	25-31
33946953-0	2021	Does the Kis-Balaton Water Protection System (KBWPS) Effectively Safeguard Lake Balaton from Toxic Cyanobacterial Blooms?	Water	21-26	U2AF homology motif kinase 1	Homo sapiens	9-12
33836371-3	2021	This study presents the first attempt to investigate the effect of different amplitudes of ultrasonic waves on the lacquer sap composed of water-in-oil (W/O) emulsion droplets and the mechanical properties of the resultant film by solvent evaporation.	Water	139-144	SH2 domain containing 1A	Homo sapiens	123-126
33592269-6	2021	The prepared CCMC sample with 5% CMC and 3% NaOH (CCMC53) was a qualified SAP with WA of 969.0 g/g in deionized water.	Water	112-117	SH2 domain containing 1A	Homo sapiens	74-77
33511440-3	2021	METHODS: We measured insulin-stimulated whole-body glucose disposal and glucose uptake and perfusion rates in five major muscle groups (erector spinae, obliques, rectus abdominis, hamstrings, quadriceps) in 15 healthy lean people and 37 people with obesity by using the hyperinsulinaemic-euglycaemic clamp procedure in conjunction with [2H]glucose tracer infusion (to assess whole-body glucose disposal) and positron emission tomography after injections of [15O]H2O (to assess muscle perfusion) and [18F]fluorodeoxyglucose (to assess muscle glucose uptake).	Water	462-465	insulin	Homo sapiens	21-28
32245905-1	2021	Water excretion by the kidney is regulated by the neurohypophyseal peptide hormone vasopressin through actions in renal collecting duct cells to regulate the water channel protein, aquaporin-2.	Water	0-5	arginine vasopressin	Homo sapiens	83-94
32245905-8	2021	The authors describe the use of phosphoproteomics technology to identify signaling mechanisms downstream from a Gsalpha-coupled receptor, the vasopressin V2 receptor, and its role of the regulation and dysregulation of water excretion in the kidney.	Water	219-224	GNAS complex locus	Homo sapiens	112-119
32245905-8	2021	The authors describe the use of phosphoproteomics technology to identify signaling mechanisms downstream from a Gsalpha-coupled receptor, the vasopressin V2 receptor, and its role of the regulation and dysregulation of water excretion in the kidney.	Water	219-224	arginine vasopressin receptor 2	Homo sapiens	142-165
33946953-3	2021	During late 20th century, a wetland area named the Kis-Balaton Water Protection System (KBWPS) was constructed in the hopes that it would act as a filter zone and thus ameliorate the water quality of Lake Balaton.	Water	63-68	U2AF homology motif kinase 1	Homo sapiens	51-54
33946953-3	2021	During late 20th century, a wetland area named the Kis-Balaton Water Protection System (KBWPS) was constructed in the hopes that it would act as a filter zone and thus ameliorate the water quality of Lake Balaton.	Water	183-188	U2AF homology motif kinase 1	Homo sapiens	51-54
33925248-11	2021	In sum, the iNOS-inhibitor was able to prevent strong H2O-induced degeneration in porcine retinas.	Water	54-57	nitric oxide synthase 2	Homo sapiens	12-16
33924836-5	2021	An ethanol/water antioxidant extract from chia seeds (ChE), with a high content in rosmarinic acid and rosmarinic acid 3-O-glucoside, along with other minor phenolic acids determined by HPLC-MS, was encapsulated in liposomes made of LEC (L-LEC) and PPL (L-PPL) with an entrapment efficiency of 61.3% and 69.3%, respectively.	Water	11-16	chitinase acidic	Homo sapiens	42-46
33925363-1	2021	Inquiries into the participation of short hydrogen bonds in stabilizing transition states and intermediate states in the thrombin, factor Xa, plasmin and activated protein C-catalyzed reactions revealed that specific binding of effectors at Sn, n = 1-4 and S"n, n = 1-3 and at remote exosites elicit complex patterns of hydrogen bonding and involve water networks.	Water	349-354	coagulation factor II, thrombin	Homo sapiens	121-129
33876932-0	2021	Kosmotropic Electrolyte (Na2CO3, NaF) Perturbs the Air/Water Interface through Anion Hydration Shell without Forming a Well-Defined Electric Double Layer.	Water	55-60	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
33876932-2	2021	By combining heterodyne-detected vibrational sum frequency generation (HD-VSFG) with differential spectroscopy involving simultaneous curve fitting (DS-SCF) analysis, we retrieve electrolyte (Na2CO3 and NaF)-correlated OH-stretch spectra of water at the air/water interface.	Water	241-246	C-X-C motif chemokine ligand 8	Homo sapiens	203-206
33876932-2	2021	By combining heterodyne-detected vibrational sum frequency generation (HD-VSFG) with differential spectroscopy involving simultaneous curve fitting (DS-SCF) analysis, we retrieve electrolyte (Na2CO3 and NaF)-correlated OH-stretch spectra of water at the air/water interface.	Water	258-263	C-X-C motif chemokine ligand 8	Homo sapiens	203-206
34007509-2	2021	Since FAC has abundant surface functional groups and a desired porous structure that is favorable for the removal of As(V) in contaminated water, FAC has greatly enhanced the As(V) adsorption capacity of the original BC.	Water	139-144	FA complementation group C	Homo sapiens	6-9
34007509-2	2021	Since FAC has abundant surface functional groups and a desired porous structure that is favorable for the removal of As(V) in contaminated water, FAC has greatly enhanced the As(V) adsorption capacity of the original BC.	Water	139-144	FA complementation group C	Homo sapiens	146-149
33899541-8	2021	Serum analysis showed that hydrogen-rich water addition resulted in more effective reductions of total-cholesterol, low-density lipoprotein-cholesterol, and apolipoprotein B levels compared with conventional treatment.	Water	41-46	apolipoprotein B	Homo sapiens	157-173
33904139-1	2021	Tolvaptan (TLV) is a vasopressin V2 receptor antagonist that increases free water excretion.	Water	76-81	arginine vasopressin receptor 2	Homo sapiens	21-44
33481291-6	2021	Both b-ketoimines and BF2 complexes, examined in mixtures of CH3CN/H2O, exhibit a significant aggregation-induced emission (AIE) behavior, due to restriction of intramolecular rotation (RIR) in the aggregated state.	Water	67-70	forkhead box G1	Homo sapiens	22-25
33485974-4	2021	METHODS: RT-qPCR was used to detect the effects of water extract of Polygoni Multiflori Radix (PMR) and its main components on the mRNA expression of CYP3A4 and UGT1A1 in human hepatic parenchyma cell line L02.	Water	51-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	150-156
33923136-6	2021	CeO2NPs have been reported to act as a ROS and reactive nitrogen species (RNS) scavenger and to have multi-enzyme mimetic activity, including SOD activity (deprotionation of superoxide anion into oxygen and hydrogen peroxide), catalase activity (conversion of hydrogen peroxide into oxygen and water), and peroxidase activity (reducing hydrogen peroxide into hydroxyl radicals).	Water	294-299	superoxide dismutase 1	Homo sapiens	142-145
33905792-1	2021	From its identification and isolation in 1954, arginine vasopressin (AVP) has attracted attention, not only for its peripheral functions such as vasoconstriction and reabsorption of water from kidney, but also for its central effects.	Water	182-187	arginine vasopressin	Homo sapiens	56-67
33997317-3	2021	Furthermore, our study demonstrated that a highly water-soluble curcuminoids-rich extract (CRE-Ter) inhibits osteoclastogenesis through NFkappaB pathway.	Water	50-55	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-144
33922514-8	2021	The detection limit (1.92 ng mL-1) was also lower than the concentration limit for drinking water set by WHO and EPA (3 and 5 ng mL-1, respectively).	Water	92-97	2'-5' oligoadenylate synthetase 1B	Mus musculus	29-33
33922514-8	2021	The detection limit (1.92 ng mL-1) was also lower than the concentration limit for drinking water set by WHO and EPA (3 and 5 ng mL-1, respectively).	Water	92-97	2'-5' oligoadenylate synthetase 1B	Mus musculus	129-133
33922161-6	2021	These results suggest that the presence of a higher amount of dietary fiber in BF pasta can affect the structure of the food matrix, interfering with the formation of the gluten network, water absorption, and starch granule accessibility, while micronization could enhance starch digestibility due to starch gelatinization.	Water	187-192	solute carrier family 45 member 1	Homo sapiens	82-87
33997368-7	2021	Thus, Codonopsis Radix may regulate water and electrolytes homeostasis by affecting AT1R expression and aldosterone biosynthesis, possibly through downregulating SP1 and TEF transcription.	Water	36-41	TEF transcription factor, PAR bZIP family member	Homo sapiens	170-173
33923314-1	2021	Efficient removal of Cd(II) and Pb(II) from contaminated water is considered a fundamental point of view.	Water	57-62	submaxillary gland androgen regulated protein 3B	Homo sapiens	21-38
33923314-9	2021	The sorbent was applied for water treatment on samples collected from the industrial area (i.e., 653 and 203 times over the MCL for Cd(II) and Pb(II) respectively according to WHO).	Water	28-33	submaxillary gland androgen regulated protein 3B	Homo sapiens	132-149
33884554-3	2021	In this study, the Dan River watershed, which is an important water source for Beijing, was investigated.	Water	29-34	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
33962203-4	2021	In particular, MnOx/ACS-4 with a Mn content of 1.06 wt% and a specific surface area of 1405.7 m2 g-1 achieved a maximum adsorption capacity of 660.7 mg g-1; this can reduce Cr(VI) content to less than 0.05 mg L-1, which meets the corresponding Chinese drinking water quality standard when the initial concentration of Cr(VI) is less than 400 mg L-1.	Water	261-266	acyl-CoA synthetase long chain family member 4	Homo sapiens	20-25
33919152-0	2021	Concentrations of Ca, Mg, P, Prostaglandin E2 in Bones and Parathyroid Hormone; 1,25-dihydroxyvitamin D3; 17-beta-estradiol; Testosterone and Somatotropin in Plasma of Aging Rats Subjected to Physical Training in Cold Water.	Water	218-223	growth hormone 1	Rattus norvegicus	142-154
33735370-6	2021	Numerous PEO-SA modified silicone formulations demonstrated effective water-driven surface hydrophilicity that was generally diminished with the addition of HMDS-treated silica filler.	Water	70-75	twinkle mtDNA helicase	Homo sapiens	9-12
33735370-10	2021	In particular, the triblock linear PEO-SA produced exceptionally high recovered G", low loss factor, and substantial water-driven restructuring to form a hydrophilic surface.	Water	117-122	twinkle mtDNA helicase	Homo sapiens	35-38
33861975-1	2021	Neodymium (Nd) based perovskite (Nd1-xCoxFeO3) nanostructures were processed to address the rising energy and environment crisis through offering solutions by photocatalytic and photoelectrochemical (PEC) water splitting reactions.	Water	205-210	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	33-36
33883673-2	2021	Potential evapotranspiration (ETp) is a measure of the ability of the atmosphere to remove water from the surface through the processes of evaporation and transpiration.	Water	91-96	major facilitator superfamily domain containing 11	Homo sapiens	30-33
33964654-1	2021	A green and efficient analytical approach was reported for simultaneous preconcentration, and separation of Pb(II) and Cd(II) in water, vegetables, and barbecue samples by dispersive solid-phase microextraction prior to their determination using flame atomic absorption spectrometry.	Water	129-134	submaxillary gland androgen regulated protein 3B	Homo sapiens	108-114
33871877-1	2021	KEY POINTS: Activation of V1a vasopressin receptors facilitates neuronal excitability in the medial nucleus of central amygdala (CeM) V1a receptor activation excites about 80% CeM neurons by opening a cationic conductance and about 20% CeM neurons by suppressing an inwardly rectifying K+ (Kir) channels The cationic conductance activated by V1a receptors is identified as TRPC5 channels PLCbeta-mediated depletion of PIP2 is involved in V1a receptor-elicited excitation of CeM neurons Intracellular Ca2+ release and PKC are unnecessary for V1a receptor-mediated excitation of CeM neurons ABSTRACT: Arginine vasopressin (AVP) serves as a hormone in the periphery to modulate water homeostasis and a neuromodulator in the brain to regulate a diverse range of functions including anxiety, social behaviors, cognitive activities and nociception.	Water	675-680	arginine vasopressin	Homo sapiens	30-41
33684284-3	2021	We herein investigated the chlorination of BP-1 in swimming pool water and evaluated the endocrine disruption toward the human androgen receptor (AR).	Water	65-70	BP1	Homo sapiens	43-47
33871773-7	2021	Above key sites promoted the binding of MCLR/MCLR-DBPs to PP1 through the hydrogen bonds (H2O   Adda5, Tyr134   Adda5, H2O   Arg4, Tyr134   Arg4, Glu275   Arg4), ionic bonds (Asp197-Adda5, Glu275-Arg4, Asp220   Arg4), and H-pi bonds (Trp206   Adda5, Ser129   Adda5).	Water	90-93	neuropeptide Y receptor Y4	Homo sapiens	58-61
33871773-7	2021	Above key sites promoted the binding of MCLR/MCLR-DBPs to PP1 through the hydrogen bonds (H2O   Adda5, Tyr134   Adda5, H2O   Arg4, Tyr134   Arg4, Glu275   Arg4), ionic bonds (Asp197-Adda5, Glu275-Arg4, Asp220   Arg4), and H-pi bonds (Trp206   Adda5, Ser129   Adda5).	Water	119-122	neuropeptide Y receptor Y4	Homo sapiens	58-61
33872414-8	2021	Moreover, computational calculation for ADME properties for the most active compounds 9d, 9e, 10c, and 11c revealed the expected high gastrointestinal tract absorption, moderate water solubility with no central nervous system toxicity, and druglikeness.	Water	178-183	Rho GTPase activating protein 9	Homo sapiens	94-97
33920057-4	2021	The diversity of rhodopsin-containing bacteria in neuston and plankton of Lake Baikal was comparable to other studied water bodies.	Water	118-123	rhodopsin	Homo sapiens	17-26
33861503-1	2021	In the present study, a novel cold water-soluble polysaccharide fraction (LGP) with the average molecular weight of 1.78x10 6 Da was extracted and purified from Leucopaxillus giganteus and its primary structure as well as in vivo antitumor activity was evaluated.	Water	35-40	secretoglobin, family 1B, member 2	Mus musculus	74-77
33935689-3	2021	D-penicillamine (D-Pen) is a water-soluble metal chelator and can reduce the aggregation of amyloid-beta (Abeta) with metals in vitro.	Water	29-34	proprotein convertase subtilisin/kexin type 1 inhibitor	Mus musculus	19-22
33933789-6	2021	The SAP absorption capacity in deionised water was related to the superabsorbent structure and morphology.	Water	41-46	SH2 domain containing 1A	Homo sapiens	4-7
33936006-1	2021	Cytochrome P450 enzymes, or P450s, are haem monooxygenases renowned for their ability to insert one atom from molecular oxygen into an exceptionally broad range of substrates while reducing the other atom to water.	Water	208-213	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
33385560-11	2021	Right lateralized TSPO expression in the amygdala predicted better performance in the Morris water maze (beta = -0.470, p = 0.013), irrespective of the global microglial activation and amyloid level.	Water	93-98	translocator protein	Mus musculus	18-22
33859225-5	2021	We further demonstrate their vertical and lateral separation that is likely due to distinct temporal emplacements of Lena and Yenisei/Ob waters in the TPD as well as prior mixing of Yenisei/Ob water with ambient waters.	Water	137-142	cadherin 11	Homo sapiens	134-136
33851772-0	2021	Water-assisted concerted proton-electron transfer at Co(II)-aquo sites in polyoxotungstates with photogenerated RuIII(bpy)33+ oxidant.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
33851772-2	2021	Mechanistic evidence has been acquired indicating that: (i) the one-electron oxidation of Co6 involves Co(II) aquo or Co(II) hydroxo groups (abbreviated as Co6(II)-OH2 and Co6(II)-OH, respectively, whose speciation in aqueous solution is associated to a pKa of 7.6), and generates a Co(III)-OH moiety (Co6(III)-OH), as proven by transient absorption spectroscopy; (ii) at pH > pKa, the Co6(II)-OH   RuIII(bpy)33+ ET occurs via bimolecular kinetics, with a rate constant k close to the diffusion limit and dependent on the ionic strength of the medium, consistent with reaction between charged species; (iii) at pH < pKa, the process involves Co6(II)-OH2   Co6(III)-OH transformation and proceeds via a multiple-site, concerted proton electron transfer (CPET) where water assists the transfer of the proton, as proven by the absence of effect of buffer base concentrations on the rate of the ET and by a H/D kinetic isotope in a range of 1.2 - 1.4.	Water	765-770	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
33851772-3	2021	The reactivity of water is ascribed to its organization on the surface of the polyanionic scaffold through hydrogen bond networking involving the Co(II)-OH2 group.	Water	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
33920057-6	2021	The number of rhodopsin sequences unclassified to the phylum level was rather high: 29% in the water microbiomes and 22% in the epilithon.	Water	95-100	rhodopsin	Homo sapiens	14-23
33862114-6	2021	Nissl staining and Morris water maze (MWM) test revealed that inhibition of RAGE with FPS-ZM1 markedly attenuated cecal ligation and puncture (CLP)-induced brain damage and cognitive dysfunction.	Water	26-31	MOK protein kinase	Mus musculus	76-80
33833299-8	2021	The results reflected changes in the geochemistry, carbon content, mineralogy, and magnetic properties of the sediments that can be explained by variations in the sources of water input to the Salar de Tara.	Water	174-179	TRIO and F-actin binding protein	Homo sapiens	202-206
33924405-8	2021	Unexpectedly, in the enzymatic activity assays, only the water-soluble form of luteolin-luteolin 7,3"-disulfate-showed the ability to potently inhibit CYP51A1.	Water	57-62	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	151-158
33832439-9	2021	However, other strategies, such as the decrease in osmotic potential to preserve water status in leaves seem to be important to explain the defence response to salinity in pepper A25 plants.	Water	81-86	immunoglobulin kappa variable 1-22 (pseudogene)	Homo sapiens	179-182
33898501-1	2021	Fubaiju Hot-Water Extracts Against ARPE-19 Cell Oxidative Damage by Activating PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway.	Water	12-17	AKT serine/threonine kinase 1	Homo sapiens	84-87
33595555-10	2021	The sensor showed high selectivity and efficiency for simultaneous determination of Cu(ii), Co(ii), Ni(ii), Hg(ii), and Mn(ii) in drinking, tap, and pond water samples on a single device and detection with the naked eye.	Water	154-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-89
33898501-1	2021	Fubaiju Hot-Water Extracts Against ARPE-19 Cell Oxidative Damage by Activating PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway.	Water	12-17	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
33515602-0	2021	The key role of solvent in condensation: Mapping hydration water in liquid-liquid phase-separated FUS.	Water	59-64	FUS RNA binding protein	Homo sapiens	98-101
33848899-10	2021	Taken together, these results suggest that the combination of glyphosate and hard water, even at environmental exposure levels, enhances pyroptosis and ongoing tubulointerstitial inflammation through excessive Drp1-mediated mitochondrial fission.	Water	82-87	dynamin 1-like	Mus musculus	210-214
33916447-0	2021	Water Pores in Planar Lipid Bilayers at Fast and Slow Rise of Transmembrane Voltage.	Water	0-5	Fas activated serine/threonine kinase	Homo sapiens	40-44
33401178-2	2021	The Raman spectra of SAP solutions suggested that both the COO- and CH2 groups of SAPs interact with water.	Water	101-106	SH2 domain containing 1A	Homo sapiens	21-24
33418478-0	2021	Europium(III) complex fluorescent sensor for dual channel recognition of Sn2+ and Cu2+ ions in water.	Water	95-100	solute carrier family 38 member 5	Homo sapiens	73-76
33401178-11	2021	The difference in the CH and COO- peak shifts of SAP, which is a result of the addition of a small percentage of water, was revealed by Raman spectroscopy.	Water	113-118	SH2 domain containing 1A	Homo sapiens	49-52
33439102-0	2021	Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement via IL-10 and Sirt 1 signaling.	Water	14-19	interleukin 10	Mus musculus	102-107
33393351-7	2021	At concentrations > 2.5 mol/L direct contact between Na+ and NO3- was observed and accompanied by large band parameter changes.DFT calculations on NO3-(H2O)n (n=1-3) led to optimized geometries and vibrational frequencies which reproduced the measured ones within an accuracy of 1%.	Water	152-155	NBL1, DAN family BMP antagonist	Homo sapiens	61-64
33439102-0	2021	Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement via IL-10 and Sirt 1 signaling.	Water	14-19	heme oxygenase 1	Mus musculus	81-85
33393351-7	2021	At concentrations > 2.5 mol/L direct contact between Na+ and NO3- was observed and accompanied by large band parameter changes.DFT calculations on NO3-(H2O)n (n=1-3) led to optimized geometries and vibrational frequencies which reproduced the measured ones within an accuracy of 1%.	Water	152-155	NBL1, DAN family BMP antagonist	Homo sapiens	147-150
33393351-9	2021	The I1/21 Na+-(OH2) breathing mode in aqueous solution appears at 189 cm-1 whereas in heavy water I1/21 Na+-(OD2) is shifted to 175.6 cm-1 due to the isotope effect.	Water	92-97	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	4-9
33393351-9	2021	The I1/21 Na+-(OH2) breathing mode in aqueous solution appears at 189 cm-1 whereas in heavy water I1/21 Na+-(OD2) is shifted to 175.6 cm-1 due to the isotope effect.	Water	92-97	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	98-103
33393351-10	2021	DFT calculations on hydrated Na+(OH2)n gas phase clusters provided realistic Na+-hydrate structures with n = 4 and 5 which resembled the measured frequency of I1/21 Na+-OH2 mode quite well.Quantitative Raman analysis employing the symmetric stretching band, I1/21(a1") NO3-, has been carried out down to concentrations as low as 5.56 A  10-6 mol/L.	Water	33-36	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	258-263
33393351-10	2021	DFT calculations on hydrated Na+(OH2)n gas phase clusters provided realistic Na+-hydrate structures with n = 4 and 5 which resembled the measured frequency of I1/21 Na+-OH2 mode quite well.Quantitative Raman analysis employing the symmetric stretching band, I1/21(a1") NO3-, has been carried out down to concentrations as low as 5.56 A  10-6 mol/L.	Water	33-36	NBL1, DAN family BMP antagonist	Homo sapiens	269-272
33461097-5	2021	Studies have confirmed, that the best efficiency of radium removal from mine water was found for the NaP1 type zeolite, produced on the base of fly ash with use of NaOH.	Water	77-82	Nucleosome assembly protein 1	Drosophila melanogaster	101-105
33497678-4	2021	The mean rate of soil loss by water erosion in Ethiopia was estimated as 16.5 t ha-1 yr-1, with an annual gross soil loss of ca.	Water	30-35	Rho GTPase activating protein 45	Homo sapiens	80-89
32632658-5	2021	RESULTS: The available literature suggest the effects of increased water intake on health may be direct, due to increased urine flow or urine dilution, or indirect, mediated by a reduction in osmotically -stimulated vasopressin (AVP).	Water	67-72	arginine vasopressin	Homo sapiens	216-227
32632658-5	2021	RESULTS: The available literature suggest the effects of increased water intake on health may be direct, due to increased urine flow or urine dilution, or indirect, mediated by a reduction in osmotically -stimulated vasopressin (AVP).	Water	67-72	arginine vasopressin	Homo sapiens	229-232
33247858-7	2021	This effect likely affects water homeostasis and blood-brain barrier functions and may thus contribute to the synaptic and cognitive defects associated with Dp71 deficiency.	Water	27-32	dystrophin, muscular dystrophy	Mus musculus	157-161
32557100-3	2021	This study was designed to test the hypothesis that exposure of mothers to Pb in drinking water may alter the expression of Clstn2 and Clstn3 in offspring, which contributes to the Pb-induced learning deficiency.	Water	90-95	calsyntenin 3	Mus musculus	135-141
33636332-7	2021	Taken all together, we demonstrate that plasma treated water-derived oxidants sensitize pancreatic cancer cells to ferroptotic cell death by targeting a NRF2-HMOX1-GPX4 specific kinase signaling network.	Water	55-60	NFE2 like bZIP transcription factor 2	Homo sapiens	153-157
33399233-7	2021	In addition, the quantitative reverse-transcription polymerase chain reaction results showed that the high-level expression of BNGR-A19 was detected in the hindgut and testis, suggesting that the RYamide signaling is likely involved in the regulation of feeding, water homeostasis and testis development.	Water	263-268	neuropeptide receptor A19	Bombyx mori	127-135
33517051-0	2021	Comparison of currently available PFAS remediation technologies in water: A review.	Water	67-72	phosphoribosylformylglycinamidine synthase	Homo sapiens	34-38
33663841-12	2021	The HPP and chymosin MPC gels had a lower water-holding capacity (91-94%) than the HPP-only counterparts, but their water-holding capacity did not decrease during storage.	Water	42-47	chymosin	Camelus bactrianus	12-20
33502904-6	2021	First, RhoA boosts intracellular pressure by increasing actomyosin contractility and water influx but acts upstream of Rac1 to inhibit lamellipodia formation.	Water	85-90	ras homolog family member A	Homo sapiens	7-11
32721078-4	2021	We found that water molecules are held inside and on the surface of the Lys molecule, and the hydration structure around the tryptophan residue changes by photoexcitation.	Water	14-19	lysozyme	Homo sapiens	72-75
32658340-10	2021	Dehydration induced by restricted water access downregulated the gene expression of interleukin-1alpha and desmoglein-1 (P <= .05).	Water	34-39	interleukin 1 alpha	Rattus norvegicus	84-102
33486357-1	2021	The water extract of Centella asiatica (CAW) improves cognitive and mitochondrial function and activates the nuclear factor erythroid 2-related factor 2 (NRF2) regulated antioxidant response pathway in aged mice.	Water	4-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	154-158
33796889-2	2022	Most is reabsorbed from the proximal tubule (> 60%) via a paracellular pathway composed of the tight junction proteins claudins-2 and -12, a process driven by sodium and consequently water reabsorption.	Water	183-188	claudin 2	Homo sapiens	119-137
32683650-3	2021	Member of the peroxisome proliferator-activated receptor (PPAR) family, especially PPARgamma agonists, has been well known for their insulin-sensitizing actions, but due to low water solubility, poor penetration into the brain and associated toxicity limit their use clinically.	Water	177-182	peroxisome proliferator activated receptor alpha	Mus musculus	14-56
32683650-3	2021	Member of the peroxisome proliferator-activated receptor (PPAR) family, especially PPARgamma agonists, has been well known for their insulin-sensitizing actions, but due to low water solubility, poor penetration into the brain and associated toxicity limit their use clinically.	Water	177-182	peroxisome proliferator activated receptor alpha	Mus musculus	58-62
33787055-8	2021	For mean MEP, it was 100.08+-26.05 cm H2O in healthy participants and 69.75+-39.79 cmH2O in controls (p=0.004).	Water	38-41	cathepsin L	Homo sapiens	9-12
33485891-0	2021	Structure, morphology and reversible hysteresis nature of human serum albumin (HSA) monolayer on water surface.	Water	97-102	albumin	Homo sapiens	64-77
33485891-1	2021	Compression-decompression surface pressure (pi)-specific molecular area (A) isotherm cycle of human serum albumin (HSA) monolayer is performed on water surface at four different subphase pH conditions, i.e., below and above the isoelectric point (pI   4.7) of HSA molecule.	Water	146-151	albumin	Homo sapiens	100-113
33838573-11	2021	An out-yard water source at the age of 0-2 years was not associated with child height at that age, but it was inversely associated with child height at ages 4-6 and 11-13 years (beta = -1.605, 95% confidence interval [CI]: -2.490 to -0.720, and beta = -2.817, 95% CI: -4.411 to -1.224, respectively), after adjusting for sociodemographic and economic covariates and baseline child height.	Water	12-17	BCL2 related protein A1	Homo sapiens	178-187
33838573-11	2021	An out-yard water source at the age of 0-2 years was not associated with child height at that age, but it was inversely associated with child height at ages 4-6 and 11-13 years (beta = -1.605, 95% confidence interval [CI]: -2.490 to -0.720, and beta = -2.817, 95% CI: -4.411 to -1.224, respectively), after adjusting for sociodemographic and economic covariates and baseline child height.	Water	12-17	ATPase H+ transporting V0 subunit a2	Homo sapiens	245-254
33967604-0	2021	Anti-inflammatory effects of Flos Lonicerae Japonicae Water Extract are regulated by the STAT/NF-kappaB pathway and HO-1 expression in Virus-infected RAW264.7 cells.	Water	54-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	94-103
33967604-0	2021	Anti-inflammatory effects of Flos Lonicerae Japonicae Water Extract are regulated by the STAT/NF-kappaB pathway and HO-1 expression in Virus-infected RAW264.7 cells.	Water	54-59	heme oxygenase 1	Mus musculus	116-120
33785533-2	2021	It is a multisystem autosomal recessive disorder caused by variants in the gene for cystic fibrosis transmembrane conductance regulator (CFTR) protein, a cell-surface localised chloride channel that regulates absorption and secretion of salt and water across epithelia.	Water	246-251	CF transmembrane conductance regulator	Homo sapiens	84-135
33785533-2	2021	It is a multisystem autosomal recessive disorder caused by variants in the gene for cystic fibrosis transmembrane conductance regulator (CFTR) protein, a cell-surface localised chloride channel that regulates absorption and secretion of salt and water across epithelia.	Water	246-251	CF transmembrane conductance regulator	Homo sapiens	137-141
33238050-0	2021	Water Mobility in the Interfacial Liquid Layer of Ice/Clay Nanocomposites.	Water	0-5	carboxylesterase 2	Homo sapiens	50-53
33734708-5	2021	We further measure the sorption of CO2 and CH4 on swelling STx-1b and nonswelling IMt-2, both in the absence (dehydrated at 200  C) and the presence of sub-1W preadsorbed water (following dehydration) up to 170 bar at 50  C. We observe enhanced sorption of CO2 and CH4 in STx-1b (50 and 65% increase at 30 bar relative to dry STx-1b, respectively), while their adsorption on IMt-2 remains unchanged, indicating the absence of competition with water.	Water	171-176	SUB1 regulator of transcription	Homo sapiens	152-157
33238050-1	2021	At solid/ice interfaces, a premelting layer is formed at temperatures below the melting point of bulk water.	Water	102-107	carboxylesterase 2	Homo sapiens	9-12
33238050-3	2021	Herein, w e determined the translational diffusion coefficient D t  of water in ice/clay nanocomposites serving as model systems for permafrost by quasi elastic neutron scattering.	Water	71-76	carboxylesterase 2	Homo sapiens	80-83
33785324-12	2021	CONCLUSION: These findings support the hypothesis that drinking high nitrate water increases oral nitrate-reducing bacteria, which likely results in increased NOC.	Water	77-82	nocturnin	Homo sapiens	159-162
33630985-1	2021	To establish how the hydrophobic surfactant proteins, SP-B and SP-C, promote adsorption of lipids to an air/water interface, we used X-ray diffuse scattering (XDS) to determine an order parameter of the lipid chains (Sxray) and the bending modulus of the lipid bilayers (KC).	Water	108-113	surfactant protein B	Bos taurus	54-58
33217517-15	2021	Western blot assays showed that PRLR, STAT5alpha and cyclin D1 levels in the mammary glands of the raw HFG water decoction group were significantly increased, which was consistent with the results of cDNA microarray screening.	Water	107-112	cyclin D1	Rattus norvegicus	53-62
33842794-5	2021	The dye containing three tetraethylene glycol units reacted with bovine serum albumin in water to give fluorescent derivatives.	Water	89-94	albumin	Homo sapiens	72-85
33608073-7	2021	This method provided a feasible application for sensitive and selective detection of Pb(II) and Ag(I) in water and Chinese traditional herbs with convenient operation.	Water	105-110	submaxillary gland androgen regulated protein 3B	Homo sapiens	85-91
33187716-2	2021	Biopolymer adsorbents including chitosan hydrogel beads (CSBs) have attracted increasing attentions in water treatment for their low costs, ease in preparation, and environmental friendliness.	Water	103-108	CXADR like membrane protein	Homo sapiens	57-61
33719429-0	2021	Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective beta-Secretase (BACE1) Inhibitors over BACE2.	Water	79-84	beta-secretase 1	Homo sapiens	135-140
33719429-7	2021	The cocrystal structures of 7, a close analogue of 6, bound to BACE1 and BACE2 confirmed that one of the explicit water molecules is displaced by the propynyl group, suggesting that the difference in the relative water displacement cost may contribute to the improved selectivity.	Water	114-119	beta-secretase 1	Homo sapiens	63-68
33724853-2	2021	The compounds were functionalized with water-soluble 2,2"(ethylenedioxy) diethylamine groups, yielding a monomer (AI3) and a dimer (AI4).	Water	39-44	distal-less homeobox 3	Homo sapiens	132-135
33724853-4	2021	The fluorescence quantum yield for the AI4 dimer in water was more than 100x lower than in other solvents, or for the monomeric AI3.	Water	52-57	distal-less homeobox 3	Homo sapiens	39-42
33724853-9	2021	The transient observed upon 416 nm excitation of AI4 in water was extremely weak.	Water	56-61	distal-less homeobox 3	Homo sapiens	49-52
33744967-4	2021	Vasopressin, apelin and their receptors colocalize in hypothalamic regions essential for body fluid homeostasis and interact at the central and renal levels to regulate water homeostasis and diuresis in inverse directions.	Water	169-174	arginine vasopressin	Homo sapiens	0-11
33745438-17	2021	CONCLUSION: Hormonal imbalance between ANG II, VP, and SNS may induce hypertension and impaired water-electrolyte balance in cardiovascular diseases.	Water	96-101	angiotensinogen	Homo sapiens	39-45
33735310-8	2021	The potential mean force of the H2O molecules along the two ORF-encoded peptide channels indicated that the energy barrier was different between ORF1 and ORF8.	Water	32-35	ORF1	Homo sapiens	145-149
33823482-1	2021	The reaction between Co(II) and PMS is an appealing advanced oxidation process (AOP), where multiple reactive oxidizing species (ROS) including high-valent cobalt-oxo [Co(IV)], sulfate radical (SO4 -), and hydroxy radical ( OH) are intertwined together for degrading pollutants.	Water	206-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
33735310-9	2021	The ORF1-encoded peptide pentamer acted as a self-assembled water channel but not as an ion channel, and the ORF8 permeated neither ions nor water.	Water	60-65	ORF1	Homo sapiens	4-8
33735340-0	2021	Reply to the "comment on "impact of water on the BrO + HO2 gas-phase reaction: mechanism, kinetics and products"" by R. Chow, D. K. W. Mok, E. P. F. Lee and J. M. Dyke, Phys.	Water	36-41	MOK protein kinase	Homo sapiens	135-138
33729607-0	2021	Methylmercury Production and Degradation Under Light and Dark Conditions in the Water Column of the Hells Canyon Reservoirs, USA.	Water	80-85	helicase, lymphoid specific	Homo sapiens	100-105
33289262-2	2021	Herein, we report that an achiral cucurbit[8]uril-based supramolecular organic framework ( SOF-1 ) with the dynamic rotational conformation of tetraphenylethene units can exhibit adaptive chirality to produce M - SOF-1 or P - SOF-1 with mirror-image circular dichroism (CD) with g abs   +-10 -4 and circularly polarized luminescence (CPL) with g lum   +-10 -4 induced by L-/D- phenylalanine in water, respectively.	Water	394-399	lumican	Homo sapiens	320-323
33737267-11	2021	In the multivariable regression analysis, absent cortical venous filling (beta = 2.04; 95% CI, 0.75-3.32; P = .002) was significantly and independently associated with higher net water uptake.	Water	179-184	ATPase H+ transporting V0 subunit a2	Homo sapiens	74-82
33732014-10	2021	Results: The results illustrated that hydrogen-rich water could alleviate oxaliplatin-induced hyperalgesia, reduce the microbial diversity and alter the structure of gut microbiota, reverse the imbalance of inflammatory cytokines and oxidative stress, and decrease the expression of LPS and TLR4.	Water	52-57	toll-like receptor 4	Mus musculus	291-295
33723239-6	2021	We found that middle-aged BMP4 transgenic mice exhibited impaired memory via the Morris water maze experiment.	Water	88-93	bone morphogenetic protein 4	Mus musculus	26-30
33715130-0	2021	Elimination of selected heterocyclic aromatic emerging contaminants from water using soybean peroxidase.	Water	73-78	peroxidase	Glycine max	93-103
33715130-3	2021	In this study, feasibility of soybean peroxidase-catalyzed removal of three selected heterocyclic aromatics from water was investigated, including sensitivity to the most important operational conditions, pH (range 3.6-9.0), H2O2 concentration (range 0.10-1.50 mM), and enzyme activity (range 0.001-5.0 U/mL).	Water	113-118	peroxidase	Glycine max	38-48
33745428-6	2021	RESULTS: Hydroxypropyl beta cyclodextrin (HP-beta-CD) better solubilized AMB than both alpha-CD and beta-CD e.g, the concentration of water-soluble AMB/HP-beta-CD IC could reach 465 microg/mL.	Water	134-139	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	45-52
33732014-11	2021	Conclusion: Hydrogen-rich water may alleviate CINP by affecting the diversity and structure of the gut microbiota, and then the LPS-TLR4 pathway, which provides a direction for further research.	Water	26-31	toll-like receptor 4	Mus musculus	132-136
33551051-7	2021	The computational inversion of the PLS2 prediction model looking for the Pareto front of these six responses provides a set of experimental conditions to conduct the chromatographic determination, specifically 22% of water, mixed with 58% methanol and 20% of acetonitrile, keeping the flow rate at 0.66 mL min-1.	Water	217-222	lymphocyte cytosolic protein 1	Homo sapiens	35-39
33959329-2	2021	beta-CD was hybridized with MAA to obtain water-compactible imprinting sites for the effective removal of BPA from aqueous samples.	Water	42-47	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	0-7
33594878-3	2021	Herein, using a high level of quantum mechanical calculations, we explore the formation paths of NPs initiated by NO3  radicals, where some common atmospheric species, such as H2O, (H2O)2, NH3, and dimethylamine (DMA), can act as molecular catalysts.	Water	176-179	NBL1, DAN family BMP antagonist	Homo sapiens	114-117
33517129-7	2021	We observed that TMEM59 knockout markedly accelerated cerebral I/R in mice induced by middle cerebral artery occlusion (MCAO), as evidenced by the elevated infarction volume, neurological deficit scores, brain water contents and neuronal death, further contributing to the abnormal behaviors for mice.	Water	210-215	transmembrane protein 59	Mus musculus	17-23
33546555-2	2021	Activation of the catalyst was identified by the use of catalytic amounts of water, alcohols, etc., when B2pin2 was used in noncoordinating solvents, while for THF catalytic use of HBpin was required.	Water	77-82	telomeric repeat binding factor 1	Homo sapiens	107-111
33545104-4	2021	Amyloid aggregation is accompanied by zinc release and the suppression of water-sustained insulin dynamics, as shown by particle-induced X-ray emission and X-ray absorption spectroscopy and by neutron spectroscopy, respectively.	Water	74-79	insulin	Homo sapiens	90-97
33555192-0	2021	alpha-Lactalbumin Self-Assembled Nanoparticles with Various Morphologies, Stiffnesses, and Sizes as Pickering Stabilizers for Oil-in-Water Emulsions and Delivery of Curcumin.	Water	133-138	lactalbumin alpha	Homo sapiens	0-17
33594885-5	2021	The water vapor permeability of the HCS/KGM composite film was also improved significantly with the incorporation of beta-CD.	Water	4-9	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	117-124
33594878-3	2021	Herein, using a high level of quantum mechanical calculations, we explore the formation paths of NPs initiated by NO3  radicals, where some common atmospheric species, such as H2O, (H2O)2, NH3, and dimethylamine (DMA), can act as molecular catalysts.	Water	182-185	NBL1, DAN family BMP antagonist	Homo sapiens	114-117
33564801-5	2021	When the Cu-Ni-S and Cu-Ni-P materials were assembled into a two-electrode system, the Cu-Ni-S/NF//Cu-Ni-P/NF electrode pairs display superior water splitting activity (1.50 V@20 mA cm-2), which is one of the best electrocatalytic activities reported so far.	Water	143-148	solute carrier family 5 member 5	Homo sapiens	12-16
33564801-5	2021	When the Cu-Ni-S and Cu-Ni-P materials were assembled into a two-electrode system, the Cu-Ni-S/NF//Cu-Ni-P/NF electrode pairs display superior water splitting activity (1.50 V@20 mA cm-2), which is one of the best electrocatalytic activities reported so far.	Water	143-148	solute carrier family 5 member 5	Homo sapiens	90-94
33387711-1	2021	Biochar was prepared by torrefaction of ammonium persulphate pretreated bamboo (labeled as APBC) and applied into elimination of Pb(II) from water solutions.	Water	141-146	submaxillary gland androgen regulated protein 3B	Homo sapiens	129-135
33522413-4	2021	Here we identify novel roles for PAX2, a transcription factor crucial for kidney development, and its adaptor protein PTIP for epigenetic regulation of the Avpr2 and thus body water balance.	Water	176-181	paired box 2	Mus musculus	33-37
33522413-4	2021	Here we identify novel roles for PAX2, a transcription factor crucial for kidney development, and its adaptor protein PTIP for epigenetic regulation of the Avpr2 and thus body water balance.	Water	176-181	PAX interacting (with transcription-activation domain) protein 1	Mus musculus	118-122
33346914-1	2021	BACKGROUND AND PURPOSE: The peptide hormone vasopressin regulates water transport in the renal collecting duct largely via the V2 receptor, which triggers a cAMP-mediated activation of a protein kinase A (PKA)-dependent signaling network.	Water	66-71	arginine vasopressin	Homo sapiens	44-55
30328568-1	2021	OBJECTIVE: To observe the effect of San-Ao Decoction (, SAD) on water metabolism of bronchial asthra model mice.	Water	64-69	N(alpha)-acetyltransferase 50, NatE catalytic subunit	Mus musculus	36-39
32491060-5	2021	The ckb3 mutant had more stomatal opening and increased proline accumulation and leaf water loss.	Water	86-91	casein kinase II beta chain 3	Arabidopsis thaliana	4-8
33433349-4	2021	The surface water in the West PRE was characterized by low salinity and high NO3-, while that in the east had high salinity and low NO3-.	Water	12-17	NBL1, DAN family BMP antagonist	Homo sapiens	77-80
33629495-2	2021	Here, we studied the aggregation behavior of the hydrophobically associating water-soluble polymer poly(acrylic acid-co-octadecyl methacrylate) [P(AA-co-OMA)] prepared with nonionic surfactant as an emulsifier and bovine serum albumin (BSA) in aqueous solution.	Water	77-82	albumin	Homo sapiens	221-234
33666805-4	2021	In vivarium rats, urine osmolality (1010 +- 137 mOsm/kg H2O) and the concentration of vasopressin are high, this causes an increase in the reabsorption of solute-free water.	Water	167-172	arginine vasopressin	Rattus norvegicus	86-97
33666805-5	2021	Thus, oxytocin increases saluresis, which, against the background of a high level of endogenous vasopressin, increases the water reabsorption in the collecting ducts.	Water	123-128	arginine vasopressin	Rattus norvegicus	96-107
33264477-3	2021	We found that the diatoms rapidly accumulated NO3 - at the mat-water interface in the afternoon and 40% of the population migrated deep into the sediment, where they were exposed to dark and anoxic conditions for ~75 % of the day.	Water	63-68	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
33976904-0	2021	Fog-to-Water for Water Scarcity in Climate-Change Hazards Hotspots: Pilot Study in Southeast Asia.	Water	7-12	zinc finger protein, FOG family member 1	Homo sapiens	0-3
33976904-0	2021	Fog-to-Water for Water Scarcity in Climate-Change Hazards Hotspots: Pilot Study in Southeast Asia.	Water	17-22	zinc finger protein, FOG family member 1	Homo sapiens	0-3
33976904-6	2021	For Southeast Asia to adapt to the adverse consequences of global climate change and the growing concern of environmental water demand, fog water harvesting is considered as the most promising method to overcome water scarcity or drought.	Water	122-127	zinc finger protein, FOG family member 1	Homo sapiens	136-139
33976904-6	2021	For Southeast Asia to adapt to the adverse consequences of global climate change and the growing concern of environmental water demand, fog water harvesting is considered as the most promising method to overcome water scarcity or drought.	Water	140-145	zinc finger protein, FOG family member 1	Homo sapiens	136-139
33976904-6	2021	For Southeast Asia to adapt to the adverse consequences of global climate change and the growing concern of environmental water demand, fog water harvesting is considered as the most promising method to overcome water scarcity or drought.	Water	140-145	zinc finger protein, FOG family member 1	Homo sapiens	136-139
33976904-7	2021	Fog water collection technique is a passive, low maintenance, and sustainable option that can supply fresh drinking water to communities where fog is a common phenomenon.	Water	4-9	zinc finger protein, FOG family member 1	Homo sapiens	0-3
33976904-7	2021	Fog water collection technique is a passive, low maintenance, and sustainable option that can supply fresh drinking water to communities where fog is a common phenomenon.	Water	4-9	zinc finger protein, FOG family member 1	Homo sapiens	143-146
33976904-7	2021	Fog water collection technique is a passive, low maintenance, and sustainable option that can supply fresh drinking water to communities where fog is a common phenomenon.	Water	116-121	zinc finger protein, FOG family member 1	Homo sapiens	0-3
33976904-7	2021	Fog water collection technique is a passive, low maintenance, and sustainable option that can supply fresh drinking water to communities where fog is a common phenomenon.	Water	116-121	zinc finger protein, FOG family member 1	Homo sapiens	143-146
33976904-8	2021	Fog water harvesting system involves the use of mesh nets to collect water as fog passes through them.	Water	4-9	zinc finger protein, FOG family member 1	Homo sapiens	0-3
33976904-8	2021	Fog water harvesting system involves the use of mesh nets to collect water as fog passes through them.	Water	4-9	zinc finger protein, FOG family member 1	Homo sapiens	78-81
33976904-8	2021	Fog water harvesting system involves the use of mesh nets to collect water as fog passes through them.	Water	69-74	zinc finger protein, FOG family member 1	Homo sapiens	0-3
33976904-8	2021	Fog water harvesting system involves the use of mesh nets to collect water as fog passes through them.	Water	69-74	zinc finger protein, FOG family member 1	Homo sapiens	78-81
33976904-10	2021	In conclusion, fog water harvesting seems to be a promising method that can be implemented to overcome water scarcity and water demand in Southeast Asia.	Water	19-24	zinc finger protein, FOG family member 1	Homo sapiens	15-18
33976904-10	2021	In conclusion, fog water harvesting seems to be a promising method that can be implemented to overcome water scarcity and water demand in Southeast Asia.	Water	103-108	zinc finger protein, FOG family member 1	Homo sapiens	15-18
33976904-10	2021	In conclusion, fog water harvesting seems to be a promising method that can be implemented to overcome water scarcity and water demand in Southeast Asia.	Water	103-108	zinc finger protein, FOG family member 1	Homo sapiens	15-18
33248184-0	2021	The Antidepressant-Like Effects of the water extract of Panax ginseng and Polygala tenuifolia are mediated via the BDNF-TrkB Signaling Pathway and Neurogenesis in the Hippocampus.	Water	39-44	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	120-124
33879962-2	2021	Water-insoluble DPPH  was solubilized by beta-cyclodextrin (beta-CD) in water.	Water	0-5	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	60-67
33879962-2	2021	Water-insoluble DPPH  was solubilized by beta-cyclodextrin (beta-CD) in water.	Water	72-77	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	60-67
33398789-4	2021	Being the single most important sink of energy, NKA might seem to be an essential target of the AMPK-mediated energy saving measures, yet NKA is vital for maintenance of transmembrane Na+ and K+ gradients, water homeostasis, cellular excitability, and the Na+-coupled transport of nutrients and ions.	Water	206-211	tachykinin precursor 1	Homo sapiens	138-141
33373730-0	2021	Complete genome sequencing and comparative plasmid analysis of KPC-2-producing Klebsiella pneumoniae isolated from a hospital sewage water in Japan.	Water	133-138	carbapenem-hydrolyzing beta-lactamase KPC-2	Klebsiella pneumoniae	63-68
33373730-4	2021	METHODS: KPC-2-producing K. pneumoniae was isolated from a hospital sewage water in Japan in 2018.	Water	75-80	carbapenem-hydrolyzing beta-lactamase KPC-2	Klebsiella pneumoniae	9-14
33475948-0	2021	A Fluorescent Probe for the Fast Detection of Hypochlorite and its Applications in Water, Test Strip and Living Cells.	Water	83-88	Fas activated serine/threonine kinase	Homo sapiens	28-32
33338789-8	2021	Furthermore, treated drinking water from the DWTP using artificial infiltration exhibited high Nrf2 activity, which was not found in any of the other water samples.	Water	30-35	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
33026599-1	2021	The metabolic actions of growth hormone (GH) last a lifetime and involve several physiological functions associated with the control of body composition, energy metabolism, water regulation, immune response, cardiovascular performance, physical and mental work.	Water	173-178	growth hormone 1	Homo sapiens	25-39
33404437-1	2021	If not properly treated, water contaminated with chromium (Cr(VI)) and lead (Pb(II)) can cause severe damage to health due to the accumulation of those toxic metals in the human body.	Water	25-30	submaxillary gland androgen regulated protein 3B	Homo sapiens	77-83
33404437-11	2021	Finally, the synthesized adsorbents were efficient to remove Cr(VI) and Pb(II) from water samples of the Doce river after the environmental disaster of Mariana city, Brazil, thus showing its applicability to remediate real water samples.	Water	84-89	submaxillary gland androgen regulated protein 3B	Homo sapiens	72-78
33404437-11	2021	Finally, the synthesized adsorbents were efficient to remove Cr(VI) and Pb(II) from water samples of the Doce river after the environmental disaster of Mariana city, Brazil, thus showing its applicability to remediate real water samples.	Water	223-228	submaxillary gland androgen regulated protein 3B	Homo sapiens	72-78
33626482-2	2021	However, the role of tomato (Solanum lycopersicum L.) cryptochrome 1a (cry1a) in the blue light fluence-dependent modulation of the water deficit response remains largely elusive.	Water	132-137	cryptochrome 1	Solanum lycopersicum	54-69
33626482-2	2021	However, the role of tomato (Solanum lycopersicum L.) cryptochrome 1a (cry1a) in the blue light fluence-dependent modulation of the water deficit response remains largely elusive.	Water	132-137	cryptochrome 1	Solanum lycopersicum	71-76
33248765-6	2021	Through the adsorption isotherm model, the adsorption capacity of the hydrogel for Pb(II) and Ni(II) reaches 233.12 and 165.06 mg/g, respectively, and the removal rate of heavy metal ions in water at low concentrations exceeds 95%, showing the excellent removal rate of heavy metals.	Water	191-196	submaxillary gland androgen regulated protein 3B	Homo sapiens	83-89
33338789-9	2021	Nrf2 activity was found in water from eight of the 13 abstraction wells, collecting water from the artificial infiltration.	Water	27-32	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
33338789-9	2021	Nrf2 activity was found in water from eight of the 13 abstraction wells, collecting water from the artificial infiltration.	Water	84-89	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
33652644-8	2021	The result was a breathable perforated (with small-sized holes) textile rectangular ring microstrip patch antenna with the water vapor permeability as high as 5296.70 g/m2 per day, an air permeability as high as 510 mm/s, and with radiation gains being 4.2 dBi and 5.4 dBi in the E-plane and H-plane, respectively.	Water	123-128	Acyl-CoA binding protein 2	Drosophila melanogaster	257-260
33125963-0	2021	Laccase cross-linking of sonicated alpha-Lactalbumin improves physical and oxidative stability of CLA oil in water emulsion.	Water	109-114	lactalbumin alpha	Homo sapiens	35-52
33639734-4	2021	Insulin, when tested with these solutions, was found to show rigid conformations, relative to that in pure water.	Water	107-112	insulin	Homo sapiens	0-7
33639734-7	2021	Our study reveals that the loss of configurational entropy of insulin in arginine solution, as compared to that in pure water, is more as compared to the entropy loss in the other two amino acid solutions, which, moreover, was found to be due to the presence of motionally bound less entropic hydration water of insulin in arginine solution than in histidine or lysine solution.	Water	120-125	insulin	Homo sapiens	62-69
33639734-7	2021	Our study reveals that the loss of configurational entropy of insulin in arginine solution, as compared to that in pure water, is more as compared to the entropy loss in the other two amino acid solutions, which, moreover, was found to be due to the presence of motionally bound less entropic hydration water of insulin in arginine solution than in histidine or lysine solution.	Water	303-308	insulin	Homo sapiens	62-69
33652644-8	2021	The result was a breathable perforated (with small-sized holes) textile rectangular ring microstrip patch antenna with the water vapor permeability as high as 5296.70 g/m2 per day, an air permeability as high as 510 mm/s, and with radiation gains being 4.2 dBi and 5.4 dBi in the E-plane and H-plane, respectively.	Water	123-128	Acyl-CoA binding protein 2	Drosophila melanogaster	269-272
33633156-1	2021	Vasopressin (AVP) increases water permeability in the renal collecting duct through the regulation of aquaporin-2 (AQP2) trafficking.	Water	28-33	arginine vasopressin	Rattus norvegicus	0-11
33633156-11	2021	Together, these findings suggest that OLE antagonizes vasopressin action through stimulation of the CaSR indicating that this extract may be beneficial to attenuate disorders characterized by abnormal CaSR signaling and affecting renal water reabsorption.	Water	236-241	arginine vasopressin	Rattus norvegicus	54-65
33534533-0	2021	Facile and Fast Transformation of Nonluminescent to Highly Luminescent Metal-Organic Frameworks: Acetone Sensing for Diabetes Diagnosis and Lead Capture from Polluted Water.	Water	167-172	Fas activated serine/threonine kinase	Homo sapiens	11-15
33545007-5	2021	Based on this, we have optimized the threshold of MRP for promoting the condensation heat transfer ability and the water harvesting efficiency with the values of 10:0-8:2 and 10:0-4:6, respectively.	Water	115-120	ATP binding cassette subfamily C member 1	Homo sapiens	50-53
33617397-4	2021	Results: MC5r(-/-) mice treated with alpha-MSH recovered from EAU, but with greater retinal damage, and the RPE suppressed phagolysosome activation in wild type but not in MC5r(-/-) macrophages.	Water	62-65	STAM binding protein	Mus musculus	37-46
33617397-6	2021	Conclusion: alpha-MSH treatment of EAU mediates a MC5r-dependent recovery of RPE suppression of phagolysosome activation in macrophages possibly altering antigen processing and presentation.	Water	35-38	STAM binding protein	Mus musculus	12-21
33545005-6	2021	In comparison, V13 bears a less symmetrical structure and reacts readily with water, allowing for recombination of a hydroxyl atom with an adsorbed hydrogen atom, akin to a fishing-mode HER process.	Water	78-83	immunoglobulin lambda variable 2-11	Homo sapiens	15-18
33558238-5	2021	Proteomics analysis was used to reveal propranolol-mediated protein alteration correlating with tumor growth inhibition, and Aquaporin-1 (AQP1), a water channel modulated in tumor cell migration and invasion, was identified.	Water	147-152	aquaporin 1 (Colton blood group)	Homo sapiens	125-136
33679168-3	2021	The reactions were carried out by using greener procedures, including a) the use of TMDP as an N-heterocycle organocatalyst in a green medium including water and ethanol (1:1 v/v) at reflux temperature, and b) the use of TMDP as a dual solvent-catalyst at 65  C in the absence of any solvent.	Water	152-157	dual specificity phosphatase 13	Homo sapiens	84-88
33558238-5	2021	Proteomics analysis was used to reveal propranolol-mediated protein alteration correlating with tumor growth inhibition, and Aquaporin-1 (AQP1), a water channel modulated in tumor cell migration and invasion, was identified.	Water	147-152	aquaporin 1 (Colton blood group)	Homo sapiens	138-142
33496718-3	2021	The prepared PVA@Gel-Sp2 exhibited a 3500% maximum water absorption ratio with a fast water absorption speed, which was suitable for blood component concentration.	Water	51-56	Sp2 transcription factor	Rattus norvegicus	21-24
33600884-2	2022	In this study, a rat ICH model was established by injecting type VII collagenase into the brain, and EGR1 knockdown reversed the increase of hematoma area, neurological function score, brain water content, blood-brain barrier (BBB) permeability, inflammation, p300 and RXRalpha protein levels, as well as RXRalpha acetylation level induced by ICH.	Water	191-196	early growth response 1	Rattus norvegicus	101-105
33387950-0	2021	Examining the robustness and concentration dependency of PFAS air-water and NAPL-water interfacial adsorption coefficients.	Water	66-71	phosphoribosylformylglycinamidine synthase	Homo sapiens	57-61
33387950-1	2021	Determining robust values for the air-water or NAPL-water interfacial adsorption coefficient, KIA, is key to characterizing and modeling PFAS transport and fate in several environmental systems.	Water	38-43	marker of proliferation Ki-67	Homo sapiens	94-97
33387950-1	2021	Determining robust values for the air-water or NAPL-water interfacial adsorption coefficient, KIA, is key to characterizing and modeling PFAS transport and fate in several environmental systems.	Water	38-43	phosphoribosylformylglycinamidine synthase	Homo sapiens	137-141
33387950-1	2021	Determining robust values for the air-water or NAPL-water interfacial adsorption coefficient, KIA, is key to characterizing and modeling PFAS transport and fate in several environmental systems.	Water	52-57	marker of proliferation Ki-67	Homo sapiens	94-97
33387950-1	2021	Determining robust values for the air-water or NAPL-water interfacial adsorption coefficient, KIA, is key to characterizing and modeling PFAS transport and fate in several environmental systems.	Water	52-57	phosphoribosylformylglycinamidine synthase	Homo sapiens	137-141
33387951-7	2021	The linear models revealed that the amount of dissolved organic carbon and of the water-soluble ions in rain samples, Ca2+, SO42-, NO3-, increases with the volume swept by the falling drops.	Water	82-87	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
33496718-3	2021	The prepared PVA@Gel-Sp2 exhibited a 3500% maximum water absorption ratio with a fast water absorption speed, which was suitable for blood component concentration.	Water	86-91	Sp2 transcription factor	Rattus norvegicus	21-24
34017962-0	2021	Cross-Flow Treatment of PFAS in Water: Materials Challenges and Potential Solutions.	Water	32-37	phosphoribosylformylglycinamidine synthase	Homo sapiens	24-28
33644043-0	2021	AQP1 Is Up-Regulated by Hypoxia and Leads to Increased Cell Water Permeability, Motility, and Migration in Neuroblastoma.	Water	60-65	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
33644043-1	2021	The water channel aquaporin 1 (AQP1) has been implicated in tumor progression and metastasis.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	31-35
33644043-2	2021	It is hypothesized that AQP1 expression can facilitate the transmembrane water transport leading to changes in cell structure that promote migration.	Water	73-78	aquaporin 1 (Colton blood group)	Homo sapiens	24-28
33679444-7	2021	Compared with the traditional diuretics, apelin exerts a positive inotropic effect on the heart, while increases water excretion.	Water	113-118	apelin	Homo sapiens	41-47
33035990-8	2021	When the precipitation was 400-600 mm, shrubland showed the lowest mean annual runoff (21.36 mm yr-1) and annual soil loss (13.36 t ha-1 yr-1), which conducive to reducing water and sediment.	Water	172-177	Rho GTPase activating protein 45	Homo sapiens	132-141
33558628-0	2021	Metal doped layered MgB2 nanoparticles as novel electrocatalysts for water splitting.	Water	69-74	secretoglobin family 2A member 1	Homo sapiens	20-24
33472367-10	2021	Additionally, thermodynamic analysis and free energy calculations shed light on the role of a structural water molecule that synergistically binds to YTHDC1 with m6A and acts as the hub of a hydrogen-bond network.	Water	105-110	YTH domain containing 1	Homo sapiens	150-156
33459307-3	2021	Herein, by the rational selection of an uncoordinated tertiary nitrogen based tricarboxylic ligand (tris[(4-carboxyl)-phenylduryl]amine, H3TCBPA), a new three-dimensional calcium-based metal-organic framework (MOF), Ca3(TCBPA)2(DMA)2(H2O)2 (1, where TCBPA = ionized tris[(4-carboxyl)-phenylduryl]amine and DMA = N,N-dimethylacetamide), possessing accessible dual catalytic sites, Lewis-basic N and Lewis-acidic Ca, has been designed and constructed by a one-pot solvothermal reaction.	Water	234-237	carbonic anhydrase 3	Homo sapiens	216-227
33559106-4	2021	As these glial cells maintain water and ion homeostasis in the brain and regulate neuronal transmission, it is likely that age- and APOE4-related changes in astrocytes have a major impact on brain functioning and play a role in age-related diseases.	Water	30-35	apolipoprotein E	Homo sapiens	132-137
33502190-8	2021	We also examined the effect of replacing water with methanol on the ease of the SN2 reaction, finding that the replacement resulted in a higher activation barrier for the generation of BrO-.	Water	41-46	solute carrier family 38 member 5	Homo sapiens	80-83
33644585-2	2021	In the present study, the synthesis of three beta-cyclodextrin (beta-CD) inclusion complexes with the oil orange SS (OOSS) azo dye as a guest molecule and their potential applications in water purification are described.	Water	187-192	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	64-71
33536373-8	2021	The results indicated that the complexes with coordinated exogenous water or chloride ligands showed higher SOD activity than those with exogenous thiocyanate ligands.	Water	68-73	superoxide dismutase 1	Homo sapiens	108-111
33038856-0	2021	A fluorescence approach on the investigation of urea derivatives interaction with a non-PET based acridinedione dye-beta Cyclodextrin (beta-CD) complex in water: Hydrogen-bonding interaction or hydrophobic influences or combined effect?	Water	155-160	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	135-142
33038856-1	2021	Photophysical studies of resorcinol based acridinedione dyes with beta Cyclodextrin (beta-CD) in the presence of urea (U) and tetramethylurea (TMU) were carried out in water.	Water	168-173	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	85-92
33038856-4	2021	The formation of urea-water hydrogen-bonding self assemblies and creation of microspheres of varying environment results in an effective displacement of dye from the hydrophobic nanocavity of beta-CD.	Water	22-27	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	192-199
33038856-6	2021	The nature of urea derivative, hydrogen-bonding of urea-water assemblies and hydrophobic influences of methyl moieties in urea molecular framework governs the stability and also the dissociation of dye-beta-CD complex.	Water	56-61	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	202-209
33410328-4	2021	In this work, we developed a new nonuniform electric field high-pressure photoionization/photoionization-induced chemical ionization (NEF-HPPI/PICI) source with the abilities of both HPPI and PICI, which was accomplished through ion-molecule reactions with high-intensity H3O+ reactant ions generated by photoelectron ionization (PEI) of water molecules.	Water	338-343	S100 calcium binding protein B	Homo sapiens	134-137
33532897-4	2021	The results showed that BAO and BC time-dependently increased neurological scores and that BC also increased water contents in the medulla at 2 h and in the pontine at 8 h. Moreover, plasma VP level increased significantly at BAO-8 h, CCAO and BC-2 h but not at BC-8 h; however, VP expressions increased in the supraoptic nucleus (SON) at BC-8 h. The neurological scores were highly correlated with pontine water contents and plasma VP levels.	Water	109-114	arginine vasopressin	Rattus norvegicus	190-192
33532897-4	2021	The results showed that BAO and BC time-dependently increased neurological scores and that BC also increased water contents in the medulla at 2 h and in the pontine at 8 h. Moreover, plasma VP level increased significantly at BAO-8 h, CCAO and BC-2 h but not at BC-8 h; however, VP expressions increased in the supraoptic nucleus (SON) at BC-8 h. The neurological scores were highly correlated with pontine water contents and plasma VP levels.	Water	407-412	arginine vasopressin	Rattus norvegicus	190-192
33217383-11	2021	Spontaneous negative monolayer curvature towards water is mediated by unsaturated, small-headgroup lipids and couples directly to GPCR activation upon light absorption by rhodopsin.	Water	49-54	rhodopsin	Homo sapiens	171-180
32596956-0	2021	Activation of the G-Protein-Coupled Receptor Rhodopsin by Water.	Water	58-63	rhodopsin	Homo sapiens	45-54
32100081-5	2021	RESULTS: The absolute volume differences of T2-spc-Silicone group were significantly less than T2-spc-H2O and T2 group (6.28 vs. 23.27 vs. 42.19 mL, P < 0.05) in vitro.	Water	102-105	proline rich protein gene cluster	Homo sapiens	98-101
33448048-0	2021	Efficient Photocatalytic Overall Water Splitting Induced by the Giant Internal Electric Field of a g-C3 N4 /rGO/PDIP Z-Scheme Heterojunction.	Water	33-38	protein disulfide isomerase family A member 2	Homo sapiens	112-116
33448048-1	2021	A graphitic carbon nitride/rGO/perylene diimide polymer (g-C3 N4 /rGO/PDIP) Z-scheme heterojunction is successfully constructed to realize high-flux charge transfer and efficient photocatalytic overall water splitting.	Water	202-207	protein disulfide isomerase family A member 2	Homo sapiens	70-74
33448048-3	2021	Thus, g-C3 N4 /rGO/PDIP presents an efficient and stable photocatalytic overall water splitting activity with H2 and O2 evolution rate of 15.80 and 7.80 micromol h-1 , respectively,  12.1 times higher than g-C3 N4 nanosheets.	Water	80-85	protein disulfide isomerase family A member 2	Homo sapiens	19-23
32596956-2	2021	Here we show experimentally for the first time that ~80 water molecules flood rhodopsin upon light absorption to form a solvent-swollen active state.	Water	56-61	rhodopsin	Homo sapiens	78-87
33469711-4	2021	After non-specific binding of Strep-ALP in wells with or without blocking agents" treatment and loading of ELF  97 phosphate (ELFP), ALP in Strep-ALP conjugates converts ELFP to water-insoluble ELF  97 alcohol (ELFA), which precipitates locally, self-assembles into large needle structures, and glows green fluorescence upon excitation.	Water	178-183	alkaline phosphatase, placental	Homo sapiens	36-39
33360412-1	2021	BACKGROUND: In December 2013, it was discovered that drinking water supplied to one third of the households in Ronneby, southern Sweden, was highly contaminated by PFAS (sum level >10,000 ng/L) originated from firefighting foams used at a nearby military airport.	Water	62-67	phosphoribosylformylglycinamidine synthase	Homo sapiens	164-168
33354944-4	2021	The experimental solubility of the [Cn THT][NTf2 ]-ILs in water (75 to 2.2 mg/L for C4 to C10 ) was modelled with very good agreement by Perturbed Chain Statistical Associating Fluid Theory (PC-SAFT), based on the extremely low vapor pressures for the [Cn THT][NTf2 ]-ILs measured in this work (4.15 to 0.037   10-7 xpsat for C4 to C10 ).	Water	58-63	homeobox C10	Homo sapiens	90-93
33399590-1	2021	Using terahertz spectroscopy, we established the alteration of the collective hydration of water during the fibrillation process (native   intermediate   fibril) of a model protein bovine serum albumin.	Water	91-96	albumin	Homo sapiens	188-201
33539179-1	2021	BACKGROUND: High levels of nitrate (NO3-) in drinking water cause methemoglobinemia in infants; however, few studies have examined the potential effects of low-level exposure on fetal growth, and the results have been inconsistent.	Water	54-59	NBL1, DAN family BMP antagonist	Homo sapiens	36-39
33247334-0	2021	Trace Elements and Their Variation with pH in Rain Water in Arid Environment.	Water	51-56	Ras interacting protein 1	Homo sapiens	46-50
31999938-10	2021	Moreover, miR-126 participated in the regulation of phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (Akt)/ glycogen synthase kinase-3beta (GSK-3beta) and extracellular signal-regulated kinase (ERK)1/2 signaling in EPCs, where both pathways were activated after miR-126 overexpression in H2O2-treated EPCs.	Water	294-298	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	52-81
31999938-10	2021	Moreover, miR-126 participated in the regulation of phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (Akt)/ glycogen synthase kinase-3beta (GSK-3beta) and extracellular signal-regulated kinase (ERK)1/2 signaling in EPCs, where both pathways were activated after miR-126 overexpression in H2O2-treated EPCs.	Water	294-298	AKT serine/threonine kinase 1	Rattus norvegicus	108-111
31999938-11	2021	Overall, we showed that miR-126 promoted the biological function of EPCs under H2O2-induced oxidative stress by activating the PI3K/Akt/GSK-3beta and ERK1/2 signaling pathway, which may serve as a new therapeutic approach to treat AMI.	Water	79-83	AKT serine/threonine kinase 1	Rattus norvegicus	132-135
33360412-8	2021	Ronneby residents who resided in the area with contaminated water supply during 2005-2013 showed much higher PFAS levels in 2014 than those exposed only before 2005.	Water	60-65	phosphoribosylformylglycinamidine synthase	Homo sapiens	109-113
33360412-9	2021	Ronneby residents who never resided in the area with contaminated water supply also had higher serum PFAS levels than the reference group.	Water	66-71	phosphoribosylformylglycinamidine synthase	Homo sapiens	101-105
33084182-12	2021	It was also shown a reduction in water content in the brain of ApoE KO.	Water	33-38	apolipoprotein E	Mus musculus	63-67
33129844-3	2021	METHODS: Gastrin-deficient mice were given N-methyl-N-nitrosourea (MNU) in drinking water along with Helicobacter felis to induce gastric tumor formation; we also performed studies with H/K-ATPase-hIL1B mice, which develop spontaneous gastric tumors at the antral-corpus junction and have parietal cells that constitutively secrete IL1B.	Water	84-89	gastrin	Mus musculus	9-16
32170986-2	2021	UGT2B4 is a predominant UDP-glucuronosyltransferase enzyme in the human liver that plays an important role in the detoxification of bile acids, which yields water-soluble inactive compounds that can easily be excreted in the bile or urine.	Water	157-162	UDP glucuronosyltransferase family 2 member B4	Homo sapiens	0-6
31916502-9	2021	Analysis of the MD results of the most active compound (compound 49) with JAK1 showed the formation of H-bond interactions with residues Glu957, Leu959 and Gly887 and water-mediated H-bond interaction with Gly887 and His885.	Water	167-172	Janus kinase 1	Homo sapiens	74-78
33429170-2	2021	The Short TR Adiabatic Inversion Recovery prepared Ultrashort TE (STAIR-UTE) sequence can significantly suppress water signals and simultaneously image ultrashort T2 components.	Water	113-118	coagulation factor II thrombin receptor	Homo sapiens	10-12
33579452-1	2021	This work aimed to evaluate the effects of encapsulated tocotrienols (TRF) and caffeic acid (CA) in water-in-oil-in-water (W/O/W) multiple nanoemulsion with cisplatin towards cancer cells.	Water	100-105	telomeric repeat binding factor 1	Homo sapiens	70-73
33385618-7	2021	These structural constraints have important implications for the movement of the electron carriers plastocyanin and cytochrome c6 (thylakoids) and cytochrome c (cristae) and hence the separation of the membrane-associated electron donors to, and electron acceptors from, these water-soluble electron carriers.	Water	277-282	cytochrome c, somatic	Homo sapiens	116-128
33579452-1	2021	This work aimed to evaluate the effects of encapsulated tocotrienols (TRF) and caffeic acid (CA) in water-in-oil-in-water (W/O/W) multiple nanoemulsion with cisplatin towards cancer cells.	Water	116-121	telomeric repeat binding factor 1	Homo sapiens	70-73
33053236-1	2021	RATIONALE: Oxygen isotope ratio measurements of NO2 - and NO3 - by the azide method and denitrifier method are sensitive to the delta18 O of sample water.	Water	148-153	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
33044825-7	2021	The latter suggests that loperamide transport across cells is significantly influenced by the presence of the unstirred water layer (UWL), which could hinder the visualization of Pgp-efflux effects during transport assays.	Water	120-125	ATP binding cassette subfamily B member 1	Homo sapiens	179-182
33359781-0	2021	Water treadmill training protects the integrity of the blood-spinal cord barrier following SCI via the BDNF/TrkB-CREB signalling pathway.	Water	0-5	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	108-112
33487348-0	2021	Cryptochrome 1a of tomato mediates long-distance signaling of soil water deficit.	Water	67-72	cryptochrome 1	Solanum lycopersicum	0-15
33487348-1	2021	Although the blue light photoreceptors cryptochromes mediate the expression of genes related to reactive oxygen species, whether cryptochrome 1a (cry1a) regulates local and long-distance signaling of water deficit in tomato (Solanum lycopersicum L.) is unknown.	Water	200-205	cryptochrome 1	Solanum lycopersicum	129-144
33487348-1	2021	Although the blue light photoreceptors cryptochromes mediate the expression of genes related to reactive oxygen species, whether cryptochrome 1a (cry1a) regulates local and long-distance signaling of water deficit in tomato (Solanum lycopersicum L.) is unknown.	Water	200-205	cryptochrome 1	Solanum lycopersicum	146-151
33487348-4	2021	WT and cry1a plants grew similarly under irrigated conditions, whereas cry1a plants had less root biomass and length and higher tissue malondialdehyde concentrations under water deficit.	Water	172-177	cryptochrome 1	Solanum lycopersicum	71-76
33487348-6	2021	Lower stomatal density of cry1a likely increased its leaf relative water content (RWC).	Water	67-72	cryptochrome 1	Solanum lycopersicum	26-31
33504415-7	2021	Malondialdehyde (MDA) content was detected by thiobarbituric acid (TBA) method, and superoxide dismutase (SOD) activity was detected by water soluble tetrazolium-1 (WST-1) assay.	Water	136-141	superoxide dismutase 1	Homo sapiens	84-104
33504415-7	2021	Malondialdehyde (MDA) content was detected by thiobarbituric acid (TBA) method, and superoxide dismutase (SOD) activity was detected by water soluble tetrazolium-1 (WST-1) assay.	Water	136-141	superoxide dismutase 1	Homo sapiens	106-109
33572553-3	2021	We recently developed a water-floatable, bFGF-releasing membrane via a simple bFGF adsorption process following oxygen plasma treatment by utilizing a polyethylene nonwoven fabric as an adsorbent.	Water	24-29	fibroblast growth factor 2	Homo sapiens	41-45
33572553-3	2021	We recently developed a water-floatable, bFGF-releasing membrane via a simple bFGF adsorption process following oxygen plasma treatment by utilizing a polyethylene nonwoven fabric as an adsorbent.	Water	24-29	fibroblast growth factor 2	Homo sapiens	78-82
33259820-0	2021	Single intratracheal administration of cross-linked water-soluble acrylic acid polymer causes acute alveolo-interstitial inflammation and the subsequent fibrotic formation possibly via the TGF-beta1 pathway in the lung of rats.	Water	52-57	transforming growth factor, beta 1	Rattus norvegicus	189-198
33398310-0	2021	A unique Co(III)-peptoid as a fast electrocatalyst for homogeneous water oxidation with low overpotential.	Water	67-72	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	9-16
33585770-0	2021	Three-Dimensional Multilayer Vertical Filament Meshes for Enhancing Efficiency in Fog Water Harvesting.	Water	86-91	zinc finger protein, FOG family member 1	Homo sapiens	82-85
33398310-1	2021	A peptoid trimer incorporating terpyridine and ethanol forms an intermolecular cobalt(iii) complex, which performs as a soluble electrocatalyst for water oxidation with a minimal overpotential of 350 mV and a high turnover frequency of 108 s-1.	Water	148-153	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	86-89
33356164-2	2021	To investigate key features of cryptophane-Xe sensing behavior, we designed a novel water-soluble cryptophane with a pendant hydrophobic adamantyl moiety, which has good affinity for a model receptor, beta-cyclodextrin (beta-CD).	Water	84-89	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	220-227
33471997-3	2021	Here we find that surface Cu doping can bend down the band levels and decline the VBM of the CsPb1-xGexBr3 surface below the H2O/O2 potential, then prevent the Ge2+ from being oxidized into Ge4+ by water because the Cu dopant reduces the perovskite surface electron accumulation.	Water	125-128	mitogen-activated protein kinase 14	Homo sapiens	93-98
33471997-3	2021	Here we find that surface Cu doping can bend down the band levels and decline the VBM of the CsPb1-xGexBr3 surface below the H2O/O2 potential, then prevent the Ge2+ from being oxidized into Ge4+ by water because the Cu dopant reduces the perovskite surface electron accumulation.	Water	198-203	mitogen-activated protein kinase 14	Homo sapiens	93-98
33525751-2	2021	This study aimed to link the structural analysis of adsorbed lysozyme at the water/gold surface at pH 7.5 in a wide range of concentrations.	Water	77-82	lysozyme	Homo sapiens	61-69
33510166-4	2021	These micro-organisms colonized and were preserved in cryptic karstic cavities formed via meteoric water dissolution related to deglacial isostatic rebound after the terminal Cryogenian snowball Earth event.	Water	99-104	cripto, FRL-1, cryptic family 1	Homo sapiens	54-61
33504835-9	2021	The proposed method was successfully applied for the analysis of the As(III), Cd(II), Cr(III), Co(II), Ni(II), and Pb(II) ions in different environmental water samples.	Water	154-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
33440932-1	2021	The hydration thermodynamics of amyloid-beta (Abeta) and its pathogenic familial Alzheimer"s disease (FAD) mutants such as A2V, Taiwan (D7H), Tottori (D7N), and English (H6R) and the protective A2T mutant is investigated by a combination of all-atom, explicit water molecular dynamics (MD) simulations and the three-dimensional reference interaction site model (3D-RISM) theory.	Water	260-265	amyloid beta precursor protein	Homo sapiens	32-44
33491574-5	2021	In effector caspase-3, the structural rearrangement in the active site loop is shown to be facilitated by a set of invariant water (IW) molecules.	Water	125-130	caspase 3	Homo sapiens	12-21
33499011-3	2021	The characterizing and whole-genome sequencing studies of ESBL-producing bacteria from reservoir water in Singapore is still limited.	Water	97-102	EsbL	Escherichia coli	58-62
33499011-12	2021	Conclusion: The first time we reported the whole genome sequencing (WGS) data of ESBL-producing E. coli including potential pathogen (ST131) present in reservoir water in Singapore.	Water	162-167	EsbL	Escherichia coli	81-85
33499011-13	2021	The ESBL-producing E. coli from reservoir water also carrying conjugatable colistin resistance genes which may become a risk to human health.	Water	42-47	EsbL	Escherichia coli	4-8
33499637-3	2021	In order to provide a well-defined benchmark system with precisely known pairwise interactions, we chose as the reference model a flexible version of the Extended Simple Point Charge (SPC/E) water model.	Water	191-196	surfactant protein C	Homo sapiens	184-187
33045697-2	2021	These water-durable frameworks exhibit varied hydrogen production rates of 361.2, 271.3, and 327.5 mumol g-1 h-1 in 12 hour due to their slightly different donor environments of the octahedral CdII and CoII ions.	Water	6-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-206
33494453-2	2021	We aimed to clarify the roles of cutaneous water channel aquaporin-3 (AQP3) in diabetic xeroderma using type 2 diabetes model db/db mice.	Water	43-48	aquaporin 3	Mus musculus	70-74
33494382-7	2021	For TiNPs/PSF composite microsphere with density close to 1, a 100% MB removal (10 mg L-1) within 120 min at a catalyst loading of 2.5 g L-1 can be obtained under both stirring and static condition, due to well dispersing of TiO2 particles on the microsphere surface and its stable suspending in water.	Water	296-301	insulin like growth factor binding protein 7	Homo sapiens	10-13
33399603-0	2021	The rational design of Cu2-xSe@(Co,Cu)Se2 core-shell structures as bifunctional electrocatalysts for neutral-pH overall water splitting.	Water	120-125	fucosyltransferase 2	Homo sapiens	38-41
33494382-11	2021	The high catalysis efficiency, excellent reusability and good stability make this kind of TiNPs/PSF composite microsphere a promising photocatalyst for the water organic pollution treatment.	Water	156-161	insulin like growth factor binding protein 7	Homo sapiens	96-99
32896728-0	2021	As(V) adsorption by a novel core-shell magnetic nanoparticles prepared with Iron-containing water treatment residuals.	Water	92-97	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-5
33494497-8	2021	Active layers of nitrate reductase and glutamine synthetase were created on the gold surface of a biochip and tested for the sensing of nitrate and ammonium in water from an aquaponic system.	Water	160-165	glutamate-ammonia ligase	Homo sapiens	39-59
33498264-2	2021	Complex IV, or cytochrome c oxidase (COX), is the terminal enzyme of the electron transport chain, responsible for accepting electrons from cytochrome c, pumping protons to contribute to the gradient utilized by ATP synthase to produce ATP, and reducing oxygen to water.	Water	264-269	cytochrome c, somatic	Homo sapiens	15-27
33498264-2	2021	Complex IV, or cytochrome c oxidase (COX), is the terminal enzyme of the electron transport chain, responsible for accepting electrons from cytochrome c, pumping protons to contribute to the gradient utilized by ATP synthase to produce ATP, and reducing oxygen to water.	Water	264-269	cytochrome c, somatic	Homo sapiens	140-152
32896728-1	2021	A novel core-shell magnetic nanoparticle was synthesized through heterogeneous nucleation technique and utilized to remove As(V) from water.	Water	134-139	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	123-128
33461437-2	2022	In this paper, the effects of H2O and CO2 on the simultaneous removal of H2S and SO2 for the by activated carbon (TL-1) were studied.	Water	30-33	TNF superfamily member 15	Homo sapiens	114-118
33461437-4	2022	The simultaneous adsorption mechanism of H2S and SO2 on TL-1 in the presence of H2O and CO2 was discussed.	Water	80-83	TNF superfamily member 15	Homo sapiens	56-60
33461437-7	2022	The adsorbed H2S and SO2 are dissolved and ionised in the water film, which is conducive to the adsorption removal of H2S and SO2 by TL-1 and the generation of sulfuric acid (55.8%) and S8 (44.2%).	Water	58-63	TNF superfamily member 15	Homo sapiens	133-137
33461437-5	2022	Results show that the breakthrough sulfur capacity of TL-1 for the simultaneous removal of H2S and SO2 mixture reaches up to 301.6 mg S/g ads when the feed gas containing 30 vol.% H2O and 8 vol.% CO2, which is 40% higher than that without H2O.	Water	180-183	TNF superfamily member 15	Homo sapiens	54-58
33461437-5	2022	Results show that the breakthrough sulfur capacity of TL-1 for the simultaneous removal of H2S and SO2 mixture reaches up to 301.6 mg S/g ads when the feed gas containing 30 vol.% H2O and 8 vol.% CO2, which is 40% higher than that without H2O.	Water	239-242	TNF superfamily member 15	Homo sapiens	54-58
33461437-6	2022	H2O in the feed is adsorbed on the surface of TL-1 and forms a water film.	Water	0-3	TNF superfamily member 15	Homo sapiens	46-50
33461437-6	2022	H2O in the feed is adsorbed on the surface of TL-1 and forms a water film.	Water	63-68	TNF superfamily member 15	Homo sapiens	46-50
33378193-0	2021	Hydrogen-Bond-Assisted Alignment of [MCu(SeO3)4Cl(H2O)]4- (M = Fe, Ga) Anionic Layers to Form Two Polar Oxychlorides: Pb2MCu(SeO3)4Cl(H2O).	Water	50-53	mitochondrial calcium uniporter	Homo sapiens	37-40
32975004-0	2021	Selective N-terminal BRD4 bromodomain inhibitors by targeting non-conserved residues and structured water displacement.	Water	100-105	bromodomain containing 4	Homo sapiens	21-25
33378193-0	2021	Hydrogen-Bond-Assisted Alignment of [MCu(SeO3)4Cl(H2O)]4- (M = Fe, Ga) Anionic Layers to Form Two Polar Oxychlorides: Pb2MCu(SeO3)4Cl(H2O).	Water	134-137	mitochondrial calcium uniporter	Homo sapiens	37-40
33378193-2	2021	They are isostructural and crystallize in the two-dimensional [MCu(SeO3)4Cl(H2O)]4- anionic layer structure mediated with hydrogen bonds and aligned between neighboring layers which assist in building the three-dimensional framework with a polar space group.	Water	76-79	mitochondrial calcium uniporter	Homo sapiens	63-66
33199153-0	2021	Water-soluble inhibitors of ABCG2 (BCRP) - A fragment-based and computational approach.	Water	0-5	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	28-33
33477252-4	2021	Through basic parameter tests, the saturated water content of polyurethane-biochar crosslinked material (PCB) was doubled and the permeability coefficient of PCB increased by two orders of magnitude.	Water	45-50	pyruvate carboxylase	Homo sapiens	105-108
33199153-0	2021	Water-soluble inhibitors of ABCG2 (BCRP) - A fragment-based and computational approach.	Water	0-5	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	35-39
32627183-3	2021	Using SPI as a control, a theoretical basis for the adsorption behavior of mixed SPI and whey protein isolate (WPI) at the oil/water interface was established and the effects of the protein ratio and content on the emulsion stability were studied.	Water	127-132	chromogranin A	Homo sapiens	81-84
32683153-0	2021	Characteristics and mechanisms of Pb(II) sorption onto Fe-rich waste water treatment residue (WTR): A potential sustainable Pb immobilisation technology for soils.	Water	69-74	submaxillary gland androgen regulated protein 3B	Homo sapiens	34-40
32683153-2	2021	This paper discusses the ability of an Fe-rich waste, water treatment residual (WTR), to adsorb Pb(II).	Water	54-59	submaxillary gland androgen regulated protein 3B	Homo sapiens	96-102
33024350-7	2021	As a model system for drug delivery and waste-water treatment applications, the diffusion of the beta-CD:Ibuprofen inclusion complex in water is studied.	Water	46-51	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	97-104
33024350-7	2021	As a model system for drug delivery and waste-water treatment applications, the diffusion of the beta-CD:Ibuprofen inclusion complex in water is studied.	Water	136-141	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	97-104
33431993-5	2021	The concentration of NO3 + NO2 was higher than 18 mumol L-1 at both places, which was as much as 40 times higher than the northward moving South China Sea (SCS) water to the east.	Water	161-166	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
32840941-1	2021	RATIONALE: This study aims to develop a simplified denitrifier method for the delta15 N and delta18 O analysis of nitrate (NO3 - ) in natural water samples combining the method of Zhu et al [14] and the original denitrifier method of Sigman et al [12] .	Water	142-147	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
32840941-7	2021	Finally, the potential applicability of the method was demonstrated by measuring the isotopic composition of NO3 - in natural water samples.	Water	126-131	NBL1, DAN family BMP antagonist	Homo sapiens	109-112
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Water	205-210	cystathionine beta-synthase	Homo sapiens	0-27
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Water	205-210	cystathionine beta-synthase	Homo sapiens	29-32
33521096-6	2020	Early water deprivation directly affected the brain proopiomelanocortin (POMC) and hepatic glucocorticoid receptors (GR) expression and induced significant changes in various aquaporins (AQP1, AQP2, AQP4, and AQP9).	Water	6-11	proopiomelanocortin	Homo sapiens	52-71
33521096-6	2020	Early water deprivation directly affected the brain proopiomelanocortin (POMC) and hepatic glucocorticoid receptors (GR) expression and induced significant changes in various aquaporins (AQP1, AQP2, AQP4, and AQP9).	Water	6-11	proopiomelanocortin	Homo sapiens	73-77
33521096-6	2020	Early water deprivation directly affected the brain proopiomelanocortin (POMC) and hepatic glucocorticoid receptors (GR) expression and induced significant changes in various aquaporins (AQP1, AQP2, AQP4, and AQP9).	Water	6-11	aquaporin 9	Homo sapiens	209-213
33521096-8	2020	The results suggest that betaine supplementation could ameliorate the stressful effects of water deprivation on POMC and GR expression and maintain cellular osmosis through interactions with variable aquaporins expression, particularly the AQP1 and AQP2.	Water	91-96	proopiomelanocortin	Homo sapiens	112-116
33438805-0	2022	Investigation of inhibitio effect of butanol and water extracts of Matricaria chamomilla L. on Angiotensin-Converting Enzyme purified from human plasma.	Water	49-54	angiotensin I converting enzyme	Homo sapiens	95-124
33438805-2	2022	Impact of water and butanol extracts of Matricaria chamomilla L. (M. chamomilla) on purity ACE was examined.	Water	10-15	angiotensin I converting enzyme	Homo sapiens	91-94
33438805-9	2022	Water and butanol extracts of M. chamomilla demonstrated inhibitor impact on ACE activity.	Water	0-5	angiotensin I converting enzyme	Homo sapiens	77-80
33438805-13	2022	These results indicate that butanol and water extracts of M. chamomilla may have an ACE inhibitor potential.	Water	40-45	angiotensin I converting enzyme	Homo sapiens	84-87
33373250-0	2021	Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta2/gamma2/delta2-Amino Acid Derivatives.	Water	0-5	ATPase H+ transporting V0 subunit a2	Homo sapiens	117-122
33373250-0	2021	Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta2/gamma2/delta2-Amino Acid Derivatives.	Water	0-5	tryptophanyl-tRNA synthetase 1	Homo sapiens	123-136
33373250-1	2021	A highly enantioselective rhodium-catalyzed intermolecular hydroarylation of alpha-aminoalkyl acrylates using water as a direct proton source has been realized by employing a chiral bicyclo[3.3.0] diene ligand, allowing efficient access to a broad range of alpha-aryl-methyl-substituted beta2-, gamma2-, and delta2-amino esters with excellent enantioselectivities (up to 98% ee) under exceptionally mild conditions.	Water	110-115	ATPase H+ transporting V0 subunit a2	Homo sapiens	287-292
33373250-1	2021	A highly enantioselective rhodium-catalyzed intermolecular hydroarylation of alpha-aminoalkyl acrylates using water as a direct proton source has been realized by employing a chiral bicyclo[3.3.0] diene ligand, allowing efficient access to a broad range of alpha-aryl-methyl-substituted beta2-, gamma2-, and delta2-amino esters with excellent enantioselectivities (up to 98% ee) under exceptionally mild conditions.	Water	110-115	tryptophanyl-tRNA synthetase 1	Homo sapiens	295-301
33449951-7	2021	The saline solution and deionized water-cooled groups indicated the correlation of performance indices delta, DR, and AR with the obtained final ablation volume.	Water	34-39	aldo-keto reductase family 1 member B1	Bos taurus	118-120
33432047-2	2021	In this study, we describe a method for the extraction and subsequent Raman analysis of pNP present in the tissues of salt-water mussels.	Water	123-128	purine nucleoside phosphorylase	Homo sapiens	88-91
33413032-0	2021	Identification of potential SARS-CoV-2 Mpro inhibitors integrating molecular docking and water thermodynamics.	Water	89-94	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	39-43
33841756-4	2021	Sap flow measurements and dye infusion demonstrated that water flowed predominantly in discrete xylem (visually identifiable from the trunk surface) sectors along the trunk axis, each supplying limited portions of the canopy.	Water	57-62	SH2 domain containing 1A	Homo sapiens	0-3
33409712-1	2021	The objective of this study was to encapsulate the poorly water-soluble drug TM-2 into polymer micelles using mPEG2k-b-PLA2.4k to increase its aqueous solubility and improve its therapeutic effect for liver cancer.	Water	58-63	phospholipase A2 group IB	Homo sapiens	119-123
33480790-3	2021	By means of the seeding technique we estimate the size of the ice critical nucleus N_{c} for the TIP4P/Ice water model.	Water	107-112	carboxylesterase 2	Homo sapiens	62-65
33155611-0	2021	Clogged water bridges for fog harvesting.	Water	8-13	zinc finger protein, FOG family member 1	Homo sapiens	26-29
33155611-1	2021	Capillary water bridges clogged in the holes of mesh-type fog harvesters have previously been considered only as a drawback because they decrease fog-harvesting yield by hindering airflow in front of the clogged mesh in the usual wind conditions.	Water	10-15	zinc finger protein, FOG family member 1	Homo sapiens	58-61
33155611-1	2021	Capillary water bridges clogged in the holes of mesh-type fog harvesters have previously been considered only as a drawback because they decrease fog-harvesting yield by hindering airflow in front of the clogged mesh in the usual wind conditions.	Water	10-15	zinc finger protein, FOG family member 1	Homo sapiens	146-149
33155611-2	2021	In this study, we show that the role of a clogged water bridge may not be entirely negative and can contribute to increased fog harvesting by increasing the effective shade coefficient in a special condition with high fog inertia.	Water	50-55	zinc finger protein, FOG family member 1	Homo sapiens	124-127
33155611-2	2021	In this study, we show that the role of a clogged water bridge may not be entirely negative and can contribute to increased fog harvesting by increasing the effective shade coefficient in a special condition with high fog inertia.	Water	50-55	zinc finger protein, FOG family member 1	Homo sapiens	218-221
33300509-0	2021	Accessing water processable cyanido bridged chiral heterobimetallic Co(II)-Fe(III) one dimensional network.	Water	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
33300509-1	2021	A water processable cyanido bridged extended chiral heterobimetallic Co(ii)-Fe(iii) network is assembled.	Water	2-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
33346267-7	2021	The formed BAIL-water nano-interfaces in reverse muEs have exerted a positive effect on the catalytic activity of Cyt-c stored in a water pool of reverse muEs.	Water	16-21	cytochrome c, somatic	Homo sapiens	114-119
33419163-4	2021	According to our results, the surface roughness ranged between (112 +- 3) nm (Ag-SiO2)-(141 +- 5) nm (HAp), the water contact angle was in the range (74.8 +- 1.6)  (Ag-SiO2)-(70.6 +- 1.2)  (HAp), while the surface free energy was in the range of 45.4 mJ/m2 (Ag-SiO2)-46.8 mJ/m2 (HAp).	Water	112-117	BAG cochaperone 1	Homo sapiens	102-105
33419163-4	2021	According to our results, the surface roughness ranged between (112 +- 3) nm (Ag-SiO2)-(141 +- 5) nm (HAp), the water contact angle was in the range (74.8 +- 1.6)  (Ag-SiO2)-(70.6 +- 1.2)  (HAp), while the surface free energy was in the range of 45.4 mJ/m2 (Ag-SiO2)-46.8 mJ/m2 (HAp).	Water	112-117	BAG cochaperone 1	Homo sapiens	190-193
33419163-4	2021	According to our results, the surface roughness ranged between (112 +- 3) nm (Ag-SiO2)-(141 +- 5) nm (HAp), the water contact angle was in the range (74.8 +- 1.6)  (Ag-SiO2)-(70.6 +- 1.2)  (HAp), while the surface free energy was in the range of 45.4 mJ/m2 (Ag-SiO2)-46.8 mJ/m2 (HAp).	Water	112-117	BAG cochaperone 1	Homo sapiens	190-193
33346267-7	2021	The formed BAIL-water nano-interfaces in reverse muEs have exerted a positive effect on the catalytic activity of Cyt-c stored in a water pool of reverse muEs.	Water	132-137	cytochrome c, somatic	Homo sapiens	114-119
33346267-9	2021	Furthermore, the differing nature of nano-interfaces created by BAILs and water in reverse muEs, depending on the functionalization of the alkyl chain of the cationic part of BAIL, has exerted varying influence on the catalytic activity of Cyt-c.	Water	74-79	cytochrome c, somatic	Homo sapiens	240-245
33392919-6	2021	We found that in Abeta-affected brain, number of CD133+ cells was elevated after spatial training in the Morris water maze.	Water	112-117	prominin 1	Rattus norvegicus	49-54
33520283-1	2021	Two novel aluminium double salts, [Al(H2O)6](SO4)NO3 2H2O, hexa-qua-alumin-ium sulfate nitrate dihydrate, (1), and [Al(H2O)6](SO4)Cl H2O, hexaqua-aluminium sulfate chloride hydrate, (2), were obtained in the form of single crystals.	Water	38-41	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
33389440-11	2022	The aptamer is also predicted to be non-antigenic, non-allergenic, non-hemolytic, non-inflammatory, water-soluble with high affinity toward ACE2 than serum albumin.	Water	100-105	albumin	Homo sapiens	150-163
33520283-1	2021	Two novel aluminium double salts, [Al(H2O)6](SO4)NO3 2H2O, hexa-qua-alumin-ium sulfate nitrate dihydrate, (1), and [Al(H2O)6](SO4)Cl H2O, hexaqua-aluminium sulfate chloride hydrate, (2), were obtained in the form of single crystals.	Water	54-57	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
33520283-1	2021	Two novel aluminium double salts, [Al(H2O)6](SO4)NO3 2H2O, hexa-qua-alumin-ium sulfate nitrate dihydrate, (1), and [Al(H2O)6](SO4)Cl H2O, hexaqua-aluminium sulfate chloride hydrate, (2), were obtained in the form of single crystals.	Water	54-57	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
33520284-9	2021	The title compound is isotypic with its CoII and MnII analogues: the three K2 M 3(OH)2(SO4)3(H2O)2 (M = Mg, Co, Mn) structures are qu-anti-tatively compared.	Water	93-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
33146549-1	2021	We previously demonstrated that water intake increased mesenteric lymph flow and the total flux of IL-22 in rat jejunum.	Water	32-37	interleukin 22	Rattus norvegicus	99-104
33191503-0	2021	Thiophene-Bridged Donor-Acceptor sp2 -Carbon-Linked 2D Conjugated Polymers as Photocathodes for Water Reduction.	Water	96-101	Sp2 transcription factor	Homo sapiens	33-36
33146549-2	2021	The drained water and the higher permeability of albumin in the jejunal microcirculation contributed to increase the lymph flow and IL-22 transport via the activation of great bulk flow in the jejunal villi.	Water	12-17	interleukin 22	Rattus norvegicus	132-137
33146549-7	2021	Water intake accelerated immunohistochemical expressions of podoplanin and IL-22 in the interepithelial layers and lamina propria of the jejunum.	Water	0-5	interleukin 22	Rattus norvegicus	75-80
33011834-5	2021	Furthermore, 26.47% of groundwater samples exceeded the WHO drinking water guidelines for NO3- in the study region.	Water	29-34	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
32896640-8	2021	The levels of IL-1b, IL-18, and TSLP exhibited positive correlations with the AD severity index (Scoring AD index) and skin transepidermal water loss (TEWL), whereas an inverse correlation between IL-1a and Scoring AD index and IL-1a and TEWL was found.	Water	139-144	interleukin 1 beta	Homo sapiens	14-19
33010206-5	2021	Measurements by FTIR-ATR at different water activities confirm specific interactions of CGA with carbonyl and phosphate groups affecting water level along hydrocarbon region.	Water	38-43	ATR serine/threonine kinase	Homo sapiens	21-24
33297246-10	2021	Most important was that, 2,3,4-THBP could form some toxic products in the real ambient water matrix under solar irradiation, and acute toxicity of reaction mixture was 1.84 times higher than that of 2,3,4-THBP.	Water	87-92	crystallin mu	Homo sapiens	31-35
33069133-3	2021	Here, water-soluble Ag2S nanoparticles (NPs) with optimal particle size (~15 nm) were synthesized and used as the PTT agents.	Water	6-11	angiotensin II receptor, type 1a	Mus musculus	20-24
32854008-5	2021	The concentrations of total and individual halo-DBPs in the resultant water samples were quantified with high-performance liquid chromatography-tandem mass spectrometry and the cytotoxicity of DBP mixtures extracted from the water samples was evaluated using human epithelial colorectal adenocarcinoma Caco-2 cells and hepatoma HepG2 cells.	Water	70-75	D-box binding PAR bZIP transcription factor	Homo sapiens	48-51
33297175-10	2021	An aeration rate >0.3 L min-1 kg-1 DOM reduces the kCOD likely due to excess water evaporation and ventilation cooling.	Water	77-82	CD59 molecule (CD59 blood group)	Homo sapiens	24-34
33297053-2	2021	The presence of reductants in water could cause the release of soluble lead (mainly Pb(II)) from PbO2(s).	Water	30-35	submaxillary gland androgen regulated protein 3B	Homo sapiens	84-90
33007506-2	2021	The NPC-D with H2O2-sensitive linker was dispersed well in water and simultaneously interacted with nucleic acids including plasmids encoding miR-122 (p122) and EpCAM-targeted aptamer (ap1) via charge interaction and hydrogen bonding.	Water	59-64	epithelial cell adhesion molecule	Homo sapiens	161-166
32814853-0	2021	The association of fluoride in drinking water with serum calcium, vitamin D and parathyroid hormone in pregnant women and newborn infants.	Water	40-45	parathyroid hormone	Homo sapiens	80-99
32839911-3	2021	The concentrations of the ten detected pesticides ranged from not detected (ND) to 323.44 ng L-1 in different water samples from Beijing; metalaxyl was detected to have the highest concentration (89.58 ng L-1), and the detection frequencies of atrazine and metalaxyl were 100%.	Water	110-115	L1 cell adhesion molecule	Homo sapiens	93-96
32880045-6	2021	The principal component analysis (PCA) revealed the generation of three components (PC1, PC2, and PC3) with higher eigenvalues of 3 or more (3-6) explaining 40, 21, and 17% of the overall variance in water quality data sets, respectively.	Water	200-205	polycystin 2, transient receptor potential cation channel	Homo sapiens	89-92
32949006-4	2021	The observed average biennial concentration of the sum of PFOA and PFOS decreased in irrigation water, from 0.112 microg L-1 in 2013 to 0.026 microg L-1 in 2015, suggests that the 2013 Persistent Organic Pollutants Control Act may have helped to reduce levels of PFAS at this location.	Water	96-101	phosphoribosylformylglycinamidine synthase	Homo sapiens	263-267
32814853-2	2021	In the present study, it was hypothesised that varying levels of fluoride present in drinking water are associated with serum levels of calcium and the related hormones vitamin D and parathyroid hormone in pregnant women and newborn infants.	Water	94-99	parathyroid hormone	Homo sapiens	183-202
32814853-12	2021	CONCLUSIONS: Drinking water with high fluoride levels was significantly associated with calcium and the related hormones vitamin D and parathyroid hormone.	Water	22-27	parathyroid hormone	Homo sapiens	135-154
33509468-7	2021	Fast field cycling (FFC) NMR relaxometry revealed different components of the molecular dynamics in the complex PR cheese samples, which were attributed to water trapped in casein micelles, water bound to polar groups in organic components, proteins, and fats.	Water	156-161	Fas activated serine/threonine kinase	Homo sapiens	0-4
32507494-2	2021	A previously reported experiment indicated that Arabidopsis thaliana seeds with cryptochrome mutation His-CRY2 showed more robust photomorphogenic growth when hydrated with intentionally treated water as compared to untreated water.	Water	195-200	cryptochrome 2	Arabidopsis thaliana	106-110
32507494-2	2021	A previously reported experiment indicated that Arabidopsis thaliana seeds with cryptochrome mutation His-CRY2 showed more robust photomorphogenic growth when hydrated with intentionally treated water as compared to untreated water.	Water	226-231	cryptochrome 2	Arabidopsis thaliana	106-110
32507494-16	2021	Intentionally treated water improved the growth of the His-CRY2 variant of Arabidopsis, confirming results of an earlier experiment.	Water	22-27	cryptochrome 2	Arabidopsis thaliana	59-63
33125833-2	2021	AQP1 helps mediate the cellular response to osmotic stress and tissue water permeability.	Water	70-75	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
33509468-7	2021	Fast field cycling (FFC) NMR relaxometry revealed different components of the molecular dynamics in the complex PR cheese samples, which were attributed to water trapped in casein micelles, water bound to polar groups in organic components, proteins, and fats.	Water	190-195	Fas activated serine/threonine kinase	Homo sapiens	0-4
33203617-10	2021	While, addition of beta-acids from hops extract to the drinking water of mice fed RS-HFD significantly decreased serum propionate and completely eliminated RS-HFD-induced disease improvement, Treg cell increase and IL-10 production in CIA mice.	Water	64-69	interleukin 10	Mus musculus	215-220
33753590-13	2021	Among 67 case-control pairs, water consumption from well-A1 (mOR: 43.00; 95% CI: 2.60-709.88) and not washing hands with soap (mOR: 2.87; 95% CI: 1.28-6.42) were associated with illness.	Water	29-34	opioid receptor, mu 1	Mus musculus	61-64
33753590-13	2021	Among 67 case-control pairs, water consumption from well-A1 (mOR: 43.00; 95% CI: 2.60-709.88) and not washing hands with soap (mOR: 2.87; 95% CI: 1.28-6.42) were associated with illness.	Water	29-34	opioid receptor, mu 1	Mus musculus	127-130
33444139-3	2021	Rain/snow captured from practical surveillance camera, however, is always highly dynamic in time, and those videos also include occasionally transformed background scenes and background motions caused by waving leaves or water surfaces.	Water	221-226	Ras interacting protein 1	Homo sapiens	0-4
33035738-2	2021	Communities near two former military bases in Pennsylvania were exposed to PFAS through contaminated drinking water for several decades.	Water	110-115	phosphoribosylformylglycinamidine synthase	Homo sapiens	75-79
33035738-9	2021	Results indicated associations between serum levels of some PFAS compounds and sex, age, employment in the study area, PWS area, quantity of daily tap water consumption, and length of residence in the study area.	Water	151-156	phosphoribosylformylglycinamidine synthase	Homo sapiens	60-64
33009206-2	2021	Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water.	Water	209-214	catalase	Homo sapiens	158-166
32830360-9	2021	This produces different accessibility of water molecules for the catalytic aspartates of PS1, critical for Abeta production.	Water	41-46	amyloid beta precursor protein	Homo sapiens	107-112
33009206-2	2021	Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water.	Water	209-214	catalase	Homo sapiens	168-171
33270921-1	2021	Denitrifying woodchip bioreactors (DWBs) are potential low-cost technologies for the removal of nitrate (NO3 - ) in water through denitrification.	Water	116-121	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
32805671-1	2021	As an effective strategy to alleviate the global water shortage, the Janus membrane has been widely developed to harvest the fog droplets because of its advantages of timely drainage and directional droplet delivery.	Water	49-54	zinc finger protein, FOG family member 1	Homo sapiens	125-128
32814187-0	2021	Nitrogen-rich g-C3N4@AgPd Mott-Schottky heterojunction boosts photocatalytic hydrogen production from water and tandem reduction of NO3- and NO2.	Water	102-107	NBL1, DAN family BMP antagonist	Homo sapiens	132-135
32814187-1	2021	Developing an effective photocatalytic denitrification technology for NO3- and NO2- in water is urgently needed.	Water	87-92	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
32814187-6	2021	The strategy opens a new way for making the photocatalytic hydrogen production in tandem with reduction of NO3- and NO2- in water, also extending it to remove metal ion.	Water	124-129	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
32600901-3	2021	VIP is also a potent vasodilator and bronchodilator that regulates exocrine gland secretions, contributing to local innate defense by stimulating the movement of water and chloride transport across intestinal and tracheobronchial epithelia.	Water	162-167	vasoactive intestinal polypeptide	Mus musculus	0-3
33049615-5	2021	This new finding for Pb(II) removal with excellent adsorption performance using i-MOF through ion exchange based approach is a viable option for treating lead contaminated water.	Water	172-177	submaxillary gland androgen regulated protein 3B	Homo sapiens	21-27
33525967-0	2021	Trypsin inhibitor content and activity of soaking water whey as waste in soy milk processing.	Water	50-55	kunitz trypsin protease inhibitor	Glycine max	0-17
33255066-6	2021	The water contact angle of the VMPSf membrane was 22.45% lower than that of the PSf membrane.	Water	4-9	insulin like growth factor binding protein 7	Homo sapiens	33-36
32154567-2	2021	Aquaporin 1 (AQP1) is a membrane water channel protein belonging to the AQP family.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
32154567-2	2021	Aquaporin 1 (AQP1) is a membrane water channel protein belonging to the AQP family.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
33052508-4	2021	In response to solubility changes in water/tetrahydrofuran mixtures, while the piperazine bdk ligand showed aggregation caused quenching, the piperidine and morpholine bdks displayed enhanced emission upon aggregation.	Water	37-42	kininogen 1	Homo sapiens	90-93
33105135-0	2021	Syndecan-1 and Glypican-1 Knockout Alters Body Water Balance and Urine Response to Fluid Challenge in Mice.	Water	47-52	glypican 1	Mus musculus	15-25
33105135-2	2021	In this translational study, we assessed Sdc-1 and Gpc-1 knockout (KO) on whole body water balance after an intravenous volume challenge.	Water	85-90	glypican 1	Mus musculus	51-56
33105135-3	2021	Sdc-1 and Gpc-1 KO mice had higher starting blood water content versus strain-matched controls.	Water	50-55	glypican 1	Mus musculus	10-15
33073913-4	2021	Here, we show that upon leaf infiltration of water, BTH-primed Arabidopsis thaliana plants accumulate higher amounts of mRNA of ARGONAUTE (AGO)2 and AGO3, key components of RNA silencing.	Water	45-50	Argonaute family protein	Arabidopsis thaliana	139-144
33759130-3	2021	In this chapter, we describe PyRod, a novel tool to generate three-dimensional pharmacophore models based on water traces of a molecular dynamics simulation of an apo-protein.The protocol described herein was successfully applied for the discovery of novel drug-like inhibitors of West Nile virus NS2B-NS3 protease.	Water	109-114	ns2b-ns3 protease	None	297-314
33551099-7	2021	Finally there were significantly increased activities of serum AST and ALT; and the liver concentrations of MDA, SOD and CAT in boiled water exposed mice.	Water	135-140	catalase	Mus musculus	121-124
33068891-1	2021	Clearance of amyloid-beta (Abeta) from the brain is hypothesized to be mediated by the glymphatic system through aquaporin-4 (AQP4) water channels.	Water	132-137	amyloid beta precursor protein	Homo sapiens	13-25
33068891-1	2021	Clearance of amyloid-beta (Abeta) from the brain is hypothesized to be mediated by the glymphatic system through aquaporin-4 (AQP4) water channels.	Water	132-137	amyloid beta precursor protein	Homo sapiens	27-32
33415932-0	2020	Metabolic Disorders Induced by Fructosedrinking Water Affect Angiotensin II-mediated Intestinal Contractility in Male Wistar Rats.	Water	48-53	angiotensinogen	Rattus norvegicus	61-75
33369253-2	2021	We have previously reported that leg heat therapy (HT) applied using liquid-circulating trousers perfused with warm water increases leg blood flow and reduces blood pressure (BP) and the circulating levels of endothelin-1 (ET-1) in patients with symptomatic PAD.	Water	116-121	endothelin 1	Homo sapiens	209-221
33369253-2	2021	We have previously reported that leg heat therapy (HT) applied using liquid-circulating trousers perfused with warm water increases leg blood flow and reduces blood pressure (BP) and the circulating levels of endothelin-1 (ET-1) in patients with symptomatic PAD.	Water	116-121	endothelin 1	Homo sapiens	223-227
32901258-6	2020	Net assimilation rate, stomatal conductance, PSII center openness and effective quantum yield decreased, while non-photochemical quenching and catalase activity increased in both control and water-stressed plants.	Water	191-196	catalase	Homo sapiens	143-151
33424293-4	2021	The influence on photocatalytic degradation caused by typical anions in eutrophicated water body such as NO3 - and H2PO4 - was explored in this work, which revealed that both two anions had inhibitory effect on the degradation process.	Water	86-91	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
33059156-5	2021	The reactive oxygen species produced by light or microbial metabolism could have contributed to the mineralization of poorly bioavailable OC through photochemical and biogenic Fenton processes catalyzed by the indigenous Fe in lake water.	Water	232-237	bone gamma-carboxyglutamate protein	Homo sapiens	138-140
33346655-4	2020	The lysozyme structure was found to be partially folded in both reline and reline/water mixtures.	Water	82-87	lysozyme	Homo sapiens	4-12
33346655-5	2020	Root-mean-square deviation (RMSD) of the positions of Calpha atoms of lysozyme indicate that 50/50 reline/water solvent induces more destabilization in the conformation of HEWL than that by pure reline and 75/25 reline/water mixture.	Water	106-111	lysozyme	Homo sapiens	70-78
33346655-5	2020	Root-mean-square deviation (RMSD) of the positions of Calpha atoms of lysozyme indicate that 50/50 reline/water solvent induces more destabilization in the conformation of HEWL than that by pure reline and 75/25 reline/water mixture.	Water	219-224	lysozyme	Homo sapiens	70-78
33346655-6	2020	From the root-mean-square fluctuation (RMSF) analysis, it is found that the lysozyme active site (Glu35-Asp52) is quite stable in the presence of pure reline but it is least stable in the presence of 50/50 reline/water mixture.	Water	213-218	lysozyme	Homo sapiens	76-84
33396818-7	2020	In 42 PDAC patients, we observed a close association between restricted water diffusion in DW-MRI and tumor hypoxia in matched samples, as expressed by high levels of Blimp-1 and VEGF in tissue samples of the respective patients.	Water	72-77	PR/SET domain 1	Homo sapiens	167-174
33396818-7	2020	In 42 PDAC patients, we observed a close association between restricted water diffusion in DW-MRI and tumor hypoxia in matched samples, as expressed by high levels of Blimp-1 and VEGF in tissue samples of the respective patients.	Water	72-77	vascular endothelial growth factor A	Homo sapiens	179-183
33264007-4	2020	Further, P18 demonstrated significantly higher water solubility (17.61 mg/mL) and improved pharmacokinetics (e.g., t1/2 of ~20 h and oral bioavailability of 12%) than the previous analogues.	Water	47-52	H3 histone pseudogene 12	Homo sapiens	9-12
33458549-8	2021	In brief, compared to other traditional nanoadsorbents, the as-prepared Fe3O4@S-S/PMAA with improved adsorption capability and high regeneration efficiency demonstrated remarkable affinity for adsorption of Pb(II) ions, which will provide a novel technical platform for selective removal of heavy metal ions from actual polluted water.	Water	329-334	submaxillary gland androgen regulated protein 3B	Homo sapiens	207-213
33659094-1	2021	Based on the breakthrough technology of water muting on photoacoustic spectroscopy, a single wavelength photoacoustic system in the short-wavelength-infrared (SWIR) region was developed to sense the endogenous molecules (e.g. glucose, lactate, triglyceride, and serum albumin found in blood and interstitial fluid) in aqueous media.	Water	40-45	albumin	Homo sapiens	262-275
33383703-2	2020	The tree"s sap is a complex mixture of compounds, such as catechol lipids, polysaccharides, glycoproteins, enzymes, and water.	Water	120-125	SH2 domain containing 1A	Homo sapiens	11-14
33245310-1	2020	We describe the synthesis, structure, and functionalities of water-soluble linear coordination polymers of human serum albumin and haemoglobin, which are connected via a bis(terpyridyl)-Fe2+ complex.	Water	61-66	albumin	Homo sapiens	113-126
33424992-2	2020	This study aimed at evaluating the cytoprotective activity of jujube water extract (JWE) against alcohol-induced oxidative stress via the activation of the Nrf2 pathway in HepG2 cells.	Water	69-74	NFE2 like bZIP transcription factor 2	Homo sapiens	156-160
33296601-0	2020	Targeting the Trypanothione Reductase of Tissue-Residing Leishmania in Hosts" Reticuloendothelial System: A Flexible Water-Soluble Ferrocenylquinoline-Based Preclinical Drug Candidate.	Water	117-122	trypanothione reductase	Leishmania donovani	14-37
33334892-5	2021	This barrier phenotype in the Ephx3-/- pups was associated with a significant decrease in the covalently bound ceramides in the epidermis (40% reduction, p<0.05), indicating a corresponding structural impairment in the integrity of the water barrier.	Water	236-241	epoxide hydrolase 3	Mus musculus	30-35
33295178-0	2020	Salting Up and Salting Down of Bovine Serum Albumin Layers at the Air-Water Interface.	Water	70-75	albumin	Homo sapiens	38-51
33295178-1	2020	The surface adsorption of bovine serum albumin in pure water and salted aqueous solutions was studied by neutron reflection.	Water	55-60	albumin	Homo sapiens	33-46
33231222-2	2020	Herein, we present a novel ionic beta-CD derivative that shows significant surface activity and stabilizes oil-in-water emulsions prepared with hexadecane as a model oil.	Water	114-119	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	33-40
33231222-4	2020	We demonstrate the stability of the oil-in-water emulsions and verify the possibility to address the emulsion droplet surface using molecular recognition of the beta-CD cavity at the oil-water interface.	Water	187-192	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	161-168
33334374-3	2020	RESULTS: Due to the nature of a hydrophilic PEG block and a hydrophobic PA or C18-modified PA, PEG-PA, oleoyl group-conjugated PEG-PA (PEG-PAO), and stearoyl group-conjugated PEG-PA (PEG-PAS) block copolymers form micelles in water.	Water	226-231	Bardet-Biedl syndrome 9	Homo sapiens	78-81
33334114-0	2020	Effect of the air-water interface on the conformation of amyloid beta.	Water	18-23	amyloid beta precursor protein	Homo sapiens	57-69
33334114-3	2020	To address this, molecular dynamics simulation is used to investigate fragments of amyloid beta, a model fibril forming protein, at the air-water interface.	Water	140-145	amyloid beta precursor protein	Homo sapiens	83-95
33337391-1	2021	BACKGROUND: Diabetes insipidus (DI) is a disease resulting from defects in the arginine vasopressin system responsible for regulating body water homeostasis.	Water	139-144	arginine vasopressin	Homo sapiens	88-99
33403271-2	2020	This work reports the development of a novel chelating nitrogen-doped carboxylated porous carbon (ND-CPC) adsorbent for the effective removal of the heavy metal ions Pb(II), Hg(II), and Cr(VI) from contaminated and polluted water sources.	Water	224-229	submaxillary gland androgen regulated protein 3B	Homo sapiens	166-172
33403271-9	2020	Because of the fast adsorption kinetics, high removal capacity and excellent regeneration, stability, and reusability, the ND-CPC is proposed as a highly efficient remediation adsorbent for the solid-phase removal of Pb(II), Hg(II), and Cr(VI) from contaminated water.	Water	262-267	submaxillary gland androgen regulated protein 3B	Homo sapiens	217-223
33049862-1	2020	A water-soluble polysaccharide named CYP-1 was isolated from Chinese yam.	Water	2-7	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	37-42
33049819-5	2020	ATR-FTIR and zeta-potential measurements confirmed that PEG-200 can be easily washed out from the nanocellulose as PEG-200 is water miscible.	Water	126-131	ATR serine/threonine kinase	Homo sapiens	0-3
33488253-2	2020	The binding of p-sulfonylphenoxy moieties to the phthalocyanine structure favors excellent solubilities in water, as well as providing an inhibition effect on carbonic anhydrase (CA) I and II isoenzymes and paraoxonase (PON1) enzyme.	Water	107-112	paraoxonase 1	Homo sapiens	220-224
33488253-7	2020	These complexes can be more advantageous than other synthetic CA and PON inhibitors due to their water solubility.	Water	97-102	paraoxonase 1	Homo sapiens	69-72
33317300-1	2020	We study, with molecular dynamics simulations, a lysozyme protein immersed in a water-trehalose solution upon cooling.	Water	80-85	lysozyme	Homo sapiens	49-57
32987067-3	2020	To meet this demand, 5-fluorouracil-chitosan-carbon quantum dot-aptamer (5-FU-CS-CQD-Apt) nanoparticle was successfully synthesized for specific targeted delivery of 5-FU anti-cancer drug used in breast cancer treatment and this was done by following facile water-in-oil (W/O) emulsification method.	Water	258-263	LYPLA2 pseudogene 1	Homo sapiens	85-88
33403258-9	2020	Once adsorbed, amyloid beta peptide can subsequently be eluted from some MOFs by treatment with acetonitrile/water solutions, though retention strength varied between different MOFs.	Water	109-114	amyloid beta precursor protein	Homo sapiens	15-27
33157211-2	2020	In this study, we present a gentle drying technology for monoclonal antibodies, applying the water soluble 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as matrix, to prepare a solid reconstitution dosage form.	Water	93-98	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	145-152
32986294-0	2020	Release of warfarin from Human Serum Albumin by water-soluble CdSe nanotetrapods.	Water	48-53	albumin	Homo sapiens	31-44
32986294-6	2020	These water-soluble nanotetrapods disrupt the secondary structure of Human Serum Albumin (HSA) and consequently, release warfarin bound to the protein.	Water	6-11	albumin	Homo sapiens	75-88
33063990-5	2020	We also probed the high RH swelling regime using attenuated total reflection infrared (ATR-IR) spectroscopy, which allowed us to determine the degree of hydrogen bonding of the hydration water within the polysaccharide films.	Water	187-192	ATR serine/threonine kinase	Homo sapiens	87-90
33063990-6	2020	Combining the ellipsometry and ATR-IR spectroscopy results, we find that increases in the order of the hydrogen bond network of the hydration water, as specified by the ATR-IR parameter Rnetwork, lead to linear increases in K and corresponding inverse changes in lambda.	Water	142-147	ATR serine/threonine kinase	Homo sapiens	31-34
33063990-6	2020	Combining the ellipsometry and ATR-IR spectroscopy results, we find that increases in the order of the hydrogen bond network of the hydration water, as specified by the ATR-IR parameter Rnetwork, lead to linear increases in K and corresponding inverse changes in lambda.	Water	142-147	ATR serine/threonine kinase	Homo sapiens	169-172
33317300-3	2020	The alpha-relaxation shows a fragile to strong crossover about 20  higher than that in the bulk water phase and 15  higher than that in lysozyme hydration water without trehalose.	Water	155-160	lysozyme	Homo sapiens	136-144
33309309-6	2021	Mutations on the CFTR causes dysfunctional electrolyte regulation affecting intracellular water content.	Water	90-95	CF transmembrane conductance regulator	Homo sapiens	17-21
33322533-9	2020	This study will help to select an appropriate concentration of DMSO as a working solvent for the screening of water-insoluble TNF-alpha inhibitors.	Water	110-115	tumor necrosis factor	Homo sapiens	126-135
33169770-1	2020	Water-dispersed gold nanoparticles decorated with an amphiphilic cyclotetrasiloxane scaffold hold promise for the catalytic transformation of diorganosilanes to tetraorganodisiloxane-1,3-diols, (RR1SiOH)2O [R = Me or Ph R1 = Ph, cyclo-Hex] via en route formation of a Pickering emulsion.	Water	0-5	pleckstrin homology domain containing B1	Homo sapiens	217-222
33231438-4	2020	In this study, we used a combination of biophysical and cellular assays to illustrate that binding of a water-soluble meso-tetraarylporphyrin molecule to GAL-7 induces protein oligomerization and modulation of GAL-7-induced apoptosis in human Jurkat T cells.	Water	104-109	galectin 7	Homo sapiens	154-159
33241686-7	2020	This application was particularly suited for an SRR due to the extreme difference between the relative permittivity of water (epsilon = 90) and ice (epsilon = 3.2) at 5 GHz and 0  C. The results from this sensor can be used to determine the holdover time of various coatings to resist ice formation.	Water	119-124	carboxylesterase 2	Homo sapiens	285-288
33164510-3	2020	An efficient hydrophobic barrier against water quenching and toward particle disintegration is formed by PLM.	Water	41-46	FXYD domain containing ion transport regulator 1	Homo sapiens	105-108
33211495-3	2020	Herein, we report lysozyme nanofilm composite membranes (LNCM) prepared by one-step methods with hydrophobic substrates at the air/water interface.	Water	131-136	lysozyme	Homo sapiens	18-26
33231438-4	2020	In this study, we used a combination of biophysical and cellular assays to illustrate that binding of a water-soluble meso-tetraarylporphyrin molecule to GAL-7 induces protein oligomerization and modulation of GAL-7-induced apoptosis in human Jurkat T cells.	Water	104-109	galectin 7	Homo sapiens	210-215
33179662-0	2020	Water soluble ionic Co(II), Cu(II) and Zn(II) diimine-glycinate complexes targeted to tRNA: structural description, in vitro comparative binding, cleavage and cytotoxic studies towards chemoresistant prostate cancer cells.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
33179662-0	2020	Water soluble ionic Co(II), Cu(II) and Zn(II) diimine-glycinate complexes targeted to tRNA: structural description, in vitro comparative binding, cleavage and cytotoxic studies towards chemoresistant prostate cancer cells.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-25
33179662-1	2020	Four new water soluble Co(ii), Cu(ii) and Zn(ii) ionic metal complexes (1-4) [Cu(diimine)(H2O)2(glycinate)]+[glycinate]-, [Co(diimine)(H2O)4]+[glycinate]- and [Zn(diimine) (H2O)4]+[glycinate]-, where diimine = 2,2"-bipyridine (1-3) and 1,10-phenanthroline (4) were synthesized and thoroughly characterized by spectroscopic and single X-ray crystallographic studies.	Water	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
33179662-1	2020	Four new water soluble Co(ii), Cu(ii) and Zn(ii) ionic metal complexes (1-4) [Cu(diimine)(H2O)2(glycinate)]+[glycinate]-, [Co(diimine)(H2O)4]+[glycinate]- and [Zn(diimine) (H2O)4]+[glycinate]-, where diimine = 2,2"-bipyridine (1-3) and 1,10-phenanthroline (4) were synthesized and thoroughly characterized by spectroscopic and single X-ray crystallographic studies.	Water	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-28
33179662-1	2020	Four new water soluble Co(ii), Cu(ii) and Zn(ii) ionic metal complexes (1-4) [Cu(diimine)(H2O)2(glycinate)]+[glycinate]-, [Co(diimine)(H2O)4]+[glycinate]- and [Zn(diimine) (H2O)4]+[glycinate]-, where diimine = 2,2"-bipyridine (1-3) and 1,10-phenanthroline (4) were synthesized and thoroughly characterized by spectroscopic and single X-ray crystallographic studies.	Water	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
33313305-10	2020	BI 1265162 alone and in combination with CF transmembrane conductance regulator (CFTR) modulators decreased water transport and increased MCC in both normal and CF airway human epithelial models and also increased the effects of CFTR modulators in CF epithelium to reach the effect size seen in healthy epithelium with ivacaftor/lumacaftor alone.	Water	108-113	CF transmembrane conductance regulator	Homo sapiens	41-79
33374058-6	2020	The abundance of nitrification functional genes was significantly correlated with water temperature, pH, NO3-, NH4+, and organic carbon.	Water	82-87	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
33313305-10	2020	BI 1265162 alone and in combination with CF transmembrane conductance regulator (CFTR) modulators decreased water transport and increased MCC in both normal and CF airway human epithelial models and also increased the effects of CFTR modulators in CF epithelium to reach the effect size seen in healthy epithelium with ivacaftor/lumacaftor alone.	Water	108-113	CF transmembrane conductance regulator	Homo sapiens	81-85
33276572-0	2020	Metal-Polymer Complexes of Gallium/Gallium-68 with Copolymers of N-Vinylpyrrolidonewith N-Vinylformamideand N-Vinyliminodiacetic Acid: A Hint for Radiolabeling of Water-Soluble Synthetic Flexible Chain Macromolecules.	Water	163-168	histidine triad nucleotide binding protein 1	Homo sapiens	137-141
33324507-1	2020	Background: Lead (Pb(II)) exposure from drinking water consumption is a serious concern due to its negative health effect on human physiology.	Water	49-54	submaxillary gland androgen regulated protein 3B	Homo sapiens	17-24
33324507-5	2020	Objectives: The current study examined the adsorption kinetics and mechanisms of Pb(II) removing potential of biochar from water using a fixed-bed continuous flow adsorption system.	Water	123-128	submaxillary gland androgen regulated protein 3B	Homo sapiens	81-87
33324507-10	2020	Conclusions: The breakthrough data obtained from this study can be utilized to design a point of use filter that would be able to effectively remove Pb(II) from drinking water.	Water	170-175	submaxillary gland androgen regulated protein 3B	Homo sapiens	149-155
33273303-0	2020	Total Body and Extracellular Water Measures Are Unrelated to Cramp Sensitivity in Euhydrated Cramp-Prone Individuals.	Water	29-34	cathelicidin antimicrobial peptide	Homo sapiens	93-98
33273303-4	2020	As altered hydration and electrolyte imbalance have been proposed as one of 2 etiologies for exercise-associated muscle cramps (EAMC), the purpose of this study was to determine if distribution of body water is related to cramp sensitivity in similarly hydrated cramp-prone individuals.	Water	202-207	cathelicidin antimicrobial peptide	Homo sapiens	222-227
32585517-8	2020	The retention percentage for simulated water was 46.3% at a concentration of 1300 mu g L-1.	Water	39-44	L1 cell adhesion molecule	Homo sapiens	87-90
33068939-0	2020	The response of PIK3CA/KRAS-mutant colorectal cancer stem-like cells to RGD-peptide FraC produced by the strawberry anemone: A promising water-soluble peptide-based inhibitor of metastasis-driver gene CXCR4, stem cell regulatory genes and self-renewal.	Water	137-142	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	16-22
32024386-6	2020	The activation of PI3K/AKT/mTOR and Wnt/beta-catenin pathways was tested by western blot.Results: Dex attenuated H2O2-induced oxidative damage, including the decline of cell viability, the raise of apoptosis and the generation of ROS in PC12 cells by down-regulating miR-199a expression.	Water	113-117	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
32024386-6	2020	The activation of PI3K/AKT/mTOR and Wnt/beta-catenin pathways was tested by western blot.Results: Dex attenuated H2O2-induced oxidative damage, including the decline of cell viability, the raise of apoptosis and the generation of ROS in PC12 cells by down-regulating miR-199a expression.	Water	113-117	microRNA 199a-2	Rattus norvegicus	267-275
31905030-9	2020	The inhibition of JNK and p38MAPK pathways induced by cZNF609 silence was impeded by miR-145 silence.Conclusion: The protective function of cZNF609 silence in H2O2-injured HaCaT cells was revealed in vitro.	Water	159-163	mitogen-activated protein kinase 8	Homo sapiens	18-21
33068939-5	2020	The sea anemone Actinia fragacea produces a water-soluble RGD-peptide fragacea toxin C (FraC) suggesting the possible activity of FraC against PIK3CA/KRAS-mutant CRCSCs.	Water	44-49	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	143-149
32698115-6	2020	What"s more, more superior oil/water separation abilities of Z8/PC-2 monolith were manifested by the selective removal of oil or organic solvent from water within 30s, high equilibrium adsorption capacity, and excellent corrosion resistance.	Water	31-36	polycystin 2, transient receptor potential cation channel	Homo sapiens	64-68
32698115-6	2020	What"s more, more superior oil/water separation abilities of Z8/PC-2 monolith were manifested by the selective removal of oil or organic solvent from water within 30s, high equilibrium adsorption capacity, and excellent corrosion resistance.	Water	150-155	polycystin 2, transient receptor potential cation channel	Homo sapiens	64-68
33183774-7	2020	Water storage for 6 months significantly weakened all groups (P<0.05), with the Ctr group showing the lowest muTBS.	Water	0-5	calcitonin receptor	Homo sapiens	80-83
32652562-2	2020	However, the role for Th17/Th1 (CD4+ T cells co-expressing IFNgamma and IL-17A) cells in EAU is not yet understood.	Water	89-92	interferon gamma	Mus musculus	59-67
33028492-5	2020	In vivo, the absorption of erlotinib administered in tap water was decreased in omeprazole-treated (OP) rats, used as a model of gastric acid suppression, compared to control rats.	Water	57-62	nuclear RNA export factor 1	Rattus norvegicus	53-56
32767214-0	2020	Genetic characterization of ESBL-producing Escherichia coli and Klebsiella pneumoniae isolated from wastewater and river water in Tunisia: predominance of CTX-M-15 and high genetic diversity.	Water	105-110	EsbL	Escherichia coli	28-32
32767214-5	2020	Among 120 water samples, 33 and 4 contained ESBL-producing E. coli and K. pneumoniae isolates, respectively.	Water	10-15	EsbL	Escherichia coli	44-48
32767214-12	2020	Our findings show a high rate of CTX-M-15 and high genetic diversity of ESBL-E isolates from WWPP and receiving river water.	Water	118-123	EsbL	Escherichia coli	72-76
32810499-1	2020	This study aimed to gain insight into the presence of antibiotics, occurrence of antimicrobial resistance and prevalence of extended-spectrum ss-lactamase (ESBL) genes in Escherichia coli in surface water, based on the example of the Bialka river, located in one of the most attractive tourist destinations in Poland.	Water	199-204	EsbL	Escherichia coli	156-160
33259116-0	2021	From Toy to Tool: Using Water Beads for Insulin Storage in Haiti.	Water	24-29	insulin	Homo sapiens	40-47
32853617-0	2020	Adsorption of Pb(II) ions from contaminated water by 1,2,3,4-butanetetracarboxylic acid-modified microcrystalline cellulose: Isotherms, kinetics, and thermodynamic studies.	Water	44-49	submaxillary gland androgen regulated protein 3B	Homo sapiens	14-20
32853617-9	2020	Thermodynamic analysis showed that the adsorption of Pb(II) ions onto MMCC was endothermic and nonspontaneous; hence, MMCC offers an effective method of Pb(II) ion removal from aqueous solutions, with potential for water remediation processes.	Water	215-220	submaxillary gland androgen regulated protein 3B	Homo sapiens	53-59
33002580-0	2020	Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix.	Water	90-95	biglycan	Mus musculus	0-8
33002580-4	2020	However, such differences between WT and Bgn KO mice diminished once the bound water was removed from bone matrix.	Water	79-84	biglycan	Mus musculus	41-44
33002580-10	2020	In summary, the results of this study suggest that Bgn and CS in bone matrix play a pivotal role in imparting the toughness to bone most likely via retaining bound water in bone matrix.	Water	164-169	biglycan	Mus musculus	51-54
33113656-5	2020	Compared with Control-MBR, the reduction of mixed liquor suspended solids (MLSS) growth rate, extracellular polymeric substances (EPS) growth rate, total cell number and water content of SEF-MBR 1 reached 50.0%, 43.0%, 37.1% and 6.4%, respectively.	Water	170-175	interleukin 17 receptor D	Homo sapiens	187-196
32864834-4	2020	Meanwhile, the water solubility of CP-beta-CD is improved dramatically to 816 mg mL-1 , which is 440 times as that of unmodified beta-CD.	Water	15-20	carboxypeptidase A1	Homo sapiens	35-42
32864834-4	2020	Meanwhile, the water solubility of CP-beta-CD is improved dramatically to 816 mg mL-1 , which is 440 times as that of unmodified beta-CD.	Water	15-20	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	38-45
32864834-8	2020	This work suggests that the water soluble CP-beta-CD with excellent cell internalization efficiency has a potential application prospect in the field of drug delivery.	Water	28-33	carboxypeptidase A1	Homo sapiens	42-49
32594056-9	2020	The Morris water maze results demonstrated that recombinant pentraxin 3 treatment reduced the latency to the platform, increased the time spent in the correct quadrant, and increased the number of times traveled across the platform, thus suggesting an improved recovery of cognitive function.	Water	11-16	pentraxin related gene	Mus musculus	60-71
32474955-7	2020	Moreover, the formation potentials of typical carbonaceous disinfection by-products (C-DBPs) and nitrogenous disinfection by-products (N-DBPs) were assessed for the CAP polluted water treated by the UV-LED alone and UV-LED/H2 O2 processes.	Water	178-183	small integral membrane protein 10 like 2A	Homo sapiens	202-205
33170051-10	2020	The cognitive-enhancing activity of AHR against scopolamine-induced memory impairments was investigated using Y-maze, the novel object recognition test (NORT) and the Morris water maze (MWM) test.	Water	174-179	aryl-hydrocarbon receptor	Mus musculus	36-39
32474955-7	2020	Moreover, the formation potentials of typical carbonaceous disinfection by-products (C-DBPs) and nitrogenous disinfection by-products (N-DBPs) were assessed for the CAP polluted water treated by the UV-LED alone and UV-LED/H2 O2 processes.	Water	178-183	small integral membrane protein 10 like 2A	Homo sapiens	219-222
33339809-12	2020	Finally, TNT was used to remove MB from spiked pond water collecting from the KISS University, including pre- and post analysis of water quality.	Water	52-57	chromosome 16 open reading frame 82	Homo sapiens	9-12
32474955-9	2020	This study opens a new avenue for developing environment-friendly and high-performance UV-LED photocatalytic reactors for abatement of CAP pollution in water.	Water	152-157	small integral membrane protein 10 like 2A	Homo sapiens	90-93
33260358-2	2020	New Schiff base complexes [Cu2(HL1)(L1)(N3)3] 2H2O (1) and [Cu2L2(N3)2] H2O (2) were synthesized.	Water	47-50	asialoglycoprotein receptor 1	Homo sapiens	31-34
32736100-6	2020	Application of the method to the analysis of selected water samples collected at the lowest stretches of the two largest river basins of Catalonia (NE Spain), Llobregat and Ter, revealed the presence of a wide suite of pesticides in the Llobregat basin, some of them at concentrations above the water quality standards (irgarol and dichlorvos) or the acceptable method detection limits (methiocarb, imidacloprid, and thiacloprid), and much cleaner waters in the Ter River basin.	Water	54-59	trans-2,3-enoyl-CoA reductase	Homo sapiens	173-176
33174872-2	2020	The resulting [{(H2O)xM2(alpha2,alpha2"-P2W16O60)(PhPO)2}2]8- dimer clusters are stable in solution, exhibit interesting electrochemical behavior, and, for the DyIII derivative, single ion-magnet characteristics.	Water	17-20	glycoprotein hormone subunit alpha 2	Homo sapiens	25-31
33174872-2	2020	The resulting [{(H2O)xM2(alpha2,alpha2"-P2W16O60)(PhPO)2}2]8- dimer clusters are stable in solution, exhibit interesting electrochemical behavior, and, for the DyIII derivative, single ion-magnet characteristics.	Water	17-20	glycoprotein hormone subunit alpha 2	Homo sapiens	32-39
33244162-5	2020	Water-soluble fibrinogen, following cleavage by thrombin, self-polymerize to form water-insoluble fibrin.	Water	0-5	fibrinogen beta chain	Homo sapiens	14-24
33244162-5	2020	Water-soluble fibrinogen, following cleavage by thrombin, self-polymerize to form water-insoluble fibrin.	Water	0-5	coagulation factor II, thrombin	Homo sapiens	48-56
33244162-5	2020	Water-soluble fibrinogen, following cleavage by thrombin, self-polymerize to form water-insoluble fibrin.	Water	82-87	fibrinogen beta chain	Homo sapiens	14-24
33244162-5	2020	Water-soluble fibrinogen, following cleavage by thrombin, self-polymerize to form water-insoluble fibrin.	Water	82-87	coagulation factor II, thrombin	Homo sapiens	48-56
33247777-4	2020	The results of the water absorption ratio measurement, solvent resistance measurement and compressive testing showed that water absorption, hydrophilicity, and tensile strength in the dry state of the composite sponges increased with the increase of SPI content.	Water	19-24	chromogranin A	Homo sapiens	250-253
33247777-4	2020	The results of the water absorption ratio measurement, solvent resistance measurement and compressive testing showed that water absorption, hydrophilicity, and tensile strength in the dry state of the composite sponges increased with the increase of SPI content.	Water	122-127	chromogranin A	Homo sapiens	250-253
33196198-7	2020	Importantly, our studies indicate that Ca2+ plays a crucial role in binding the NOM clusters to the smectite surface, which occurs through multiple quaternary complexes (Ob)-H2O-Ca2+-COO-NOM.	Water	174-177	cadherin 11	Homo sapiens	170-172
33174561-2	2020	While the pKb is typically defined in reference to the bulk aqueous phase, several studies have suggested that this value can differ significantly at the air-water interface (which can have significant ramifications for particle surface chemistry and aerosol growth modeling).	Water	158-163	AKT serine/threonine kinase 1	Homo sapiens	10-13
32755770-3	2020	Tryptophan-like fluorescence (TLF) shows potential as a rapid method for detecting microbial contamination in drinking water, which could reduce the spread of waterborne diseases.	Water	119-124	TATA-box binding protein like 1	Homo sapiens	30-33
33188670-5	2020	Different from the case of Li3+(H2O)n, where the electrostatic interaction is dominant, the electrostatic and polarization components are found to make nearly equal contributions to Li3+(N2)n complex formation.	Water	32-35	cytochrome P450 family 4 subfamily F member 22	Homo sapiens	182-185
33266427-0	2020	Rubi Fructus Water Extract Alleviates LPS-Stimulated Macrophage Activation via an ER Stress-Induced Calcium/CHOP Signaling Pathway.	Water	13-18	DNA damage inducible transcript 3	Homo sapiens	108-112
32144103-10	2020	A vaccine that blocks ETEC fimbriae (K88 and F18) from attaching to host receptors and prevents enterotoxins from stimulating water hypersecretion in pig small intestinal epithelial cells can effectively protect against PWD and significantly improves pig health and well-being.	Water	126-131	ETEC	Sus scrofa	22-26
33325191-9	2020	Daily direct drinking of tap water is a risk factor, and anti-HIV therapy is a protective factor of B. hominis infection among AIDS patients living in Nanchang City.	Water	29-34	SEC14 like lipid binding 2	Homo sapiens	25-28
32969581-4	2020	Cells with water-based electrodes containing NCA with an optimized amount of lithium phosphate have a slightly lower specific discharge capacity as compared to cells with conventional N-Methyl-2-pyrrolidone-based electrodes.	Water	11-16	CEA cell adhesion molecule 4	Homo sapiens	45-48
32693279-4	2020	Moreover, water eutrophication could be caused due to the increase in NO3- as a product of the photocatalytic oxidation of NOx in runoff.	Water	10-15	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
32755770-15	2020	Therefore, TLF is better suited as a rapid high-level water quality screening tool to assess moderate and high levels of faecal contamination.	Water	54-59	TATA-box binding protein like 1	Homo sapiens	11-14
33228147-5	2020	We demonstrated a sterol-coupled ATPase activity of ABCG5/G8 by cholesteryl hemisuccinate (CHS), a relatively water-soluble cholesterol memetic, and characterized CHS-coupled ATPase activity of three loss-of-function missense variants, R543S, E146Q, and A540F, which are respectively within, in contact with, and distant from the polar relay.	Water	110-115	ATP binding cassette subfamily G member 5	Homo sapiens	52-57
33210172-0	2020	f-MOPSO/Div: an improved extreme-point-based multi-objective PSO algorithm applied to a socio-economic-environmental conjunctive water use problem.	Water	129-134	pipecolic acid and sarcosine oxidase	Homo sapiens	4-7
33094795-1	2020	Two kinds of Bovine Serum Albumin (BSA)-loaded microspheres were prepared in water-organic bilayer systems using ultrasonic irradiation.	Water	77-82	albumin	Homo sapiens	20-33
32652152-0	2020	Biologically active Co (II), Cu (II), Zn (II) centered water soluble novel isoniazid grafted O-carboxymethyl chitosan Schiff base ligand metal complexes: Synthesis, spectral characterisation and DNA nuclease activity.	Water	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-27
33100004-0	2020	Versatility of Amide-Functionalized Co(II) and Ni(II) Coordination Polymers: From Thermochromic-Triggered Structural Transformations to Supercapacitors and Electrocatalysts for Water Splitting.	Water	177-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
33007563-6	2020	Furthermore, compound 4o also showed improvement in Abeta-induced cognitive dysfunction by the Morris water maze test with excellent oral absorption characteristics ascertained by the pharmacokinetic study.	Water	102-107	amyloid beta precursor protein	Homo sapiens	52-57
32599246-7	2020	The hardness of the egg albumin gels was improved with the addition of 0.1% SG, and their water holding capacity (WHC) was also improved.	Water	90-95	albumin	Homo sapiens	24-31
32652152-1	2020	In this study, the new N, N, O tridentate donor water soluble isoniazid based biopolymer Schiff base ligand and their Co (II), Cu (II), Zn (II) metal complexes were prepared.	Water	48-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-125
32987076-4	2020	More importantly, when the SPC is utilized as outer coating material together with ethylcellulose (EC) as inner coating material for preparing double-layer slow-release urea (denoted as EC/SPC based SRU), the EC/SPC based SRU has a desirable slow-release behavior with release percentages of 40.9% for 12 h in water and merely 59.6% for 20 day together with even exceeding 30 days in soil.	Water	310-315	surfactant protein C	Homo sapiens	27-30
32810620-0	2020	Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-kappaB and TGF-beta/smads signaling pathways.	Water	20-25	toll-like receptor 4	Rattus norvegicus	64-68
32987076-4	2020	More importantly, when the SPC is utilized as outer coating material together with ethylcellulose (EC) as inner coating material for preparing double-layer slow-release urea (denoted as EC/SPC based SRU), the EC/SPC based SRU has a desirable slow-release behavior with release percentages of 40.9% for 12 h in water and merely 59.6% for 20 day together with even exceeding 30 days in soil.	Water	310-315	surfactant protein C	Homo sapiens	189-192
32987076-4	2020	More importantly, when the SPC is utilized as outer coating material together with ethylcellulose (EC) as inner coating material for preparing double-layer slow-release urea (denoted as EC/SPC based SRU), the EC/SPC based SRU has a desirable slow-release behavior with release percentages of 40.9% for 12 h in water and merely 59.6% for 20 day together with even exceeding 30 days in soil.	Water	310-315	surfactant protein C	Homo sapiens	189-192
33184287-5	2020	All-atom molecular dynamics simulations indicate that the FUS-LC-C fibril core is stabilized by a plethora of hydrogen bonds involving sidechains of Gln, Asn, Ser, and Tyr residues, both along and transverse to the fibril growth direction, including diverse sidechain-to-backbone, sidechain-to-sidechain, and sidechain-to-water interactions.	Water	322-327	FUS RNA binding protein	Homo sapiens	58-61
33099592-0	2020	Two-dimensional van der Waals heterostructure CdO/PtSe2: promising visible light photocatalyst for overall water splitting.	Water	107-112	cell adhesion associated, oncogene regulated	Homo sapiens	46-49
33099592-6	2020	Comparing with widely discussed bilayer systems like graphene/C3N4 and MoS2/C3N4, the CdO/PtSe2 simultaneously has several advantages or peculiarities such as the more favorable absorption of visible light, therefore CdO/PtSe2 is a promising candidate and a unique system for photocatalytic water splitting.	Water	291-296	cell adhesion associated, oncogene regulated	Homo sapiens	86-89
33173030-0	2020	Distinct CCK-positive SFO neurons are involved in persistent or transient suppression of water intake.	Water	89-94	cholecystokinin	Homo sapiens	9-12
33125226-9	2020	Altogether, the most plausible mechanism for the O-O bond formation is the water nucleophilic attack to single Co(IV)-oxo or Co(III)-oxyl centers.	Water	75-80	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	125-132
33209306-1	2020	Hot tub lung (HTL) is a pulmonary disease where a hypersensitivity pneumonitis is caused by exposure and inhalation of aerosolized non-tuberculous mycobacteria (NTM) traditionally from hot water steam.	Water	189-194	TUB bipartite transcription factor	Homo sapiens	4-7
33173030-3	2020	We previously reported that thirst-driving neurons (water neurons) in the subfornical organ (SFO) are cholecystokinin (CCK)-dependently suppressed by GABAergic interneurons under Na-depleted conditions.	Water	52-57	cholecystokinin	Homo sapiens	102-117
33182827-2	2020	Under such conditions, the swelling pressure of the SAP in soil affects water absorption by SAP, and soil structure.	Water	72-77	SH2 domain containing 1A	Homo sapiens	52-55
33182827-2	2020	Under such conditions, the swelling pressure of the SAP in soil affects water absorption by SAP, and soil structure.	Water	72-77	SH2 domain containing 1A	Homo sapiens	92-95
33173030-3	2020	We previously reported that thirst-driving neurons (water neurons) in the subfornical organ (SFO) are cholecystokinin (CCK)-dependently suppressed by GABAergic interneurons under Na-depleted conditions.	Water	52-57	cholecystokinin	Homo sapiens	119-122
33173030-5	2020	Fluorescence-microscopic Ca2+ imaging demonstrates two distinct subpopulations in CCK-positive neurons in the SFO, which are persistently activated under hyponatremic conditions or transiently activated in response to water drinking, respectively.	Water	218-223	cholecystokinin	Homo sapiens	82-85
33173030-6	2020	Optical and chemogenetic silencings of the respective types of CCK-positive neurons both significantly increase water intake under water-repleted conditions.	Water	112-117	cholecystokinin	Homo sapiens	63-66
33173030-6	2020	Optical and chemogenetic silencings of the respective types of CCK-positive neurons both significantly increase water intake under water-repleted conditions.	Water	131-136	cholecystokinin	Homo sapiens	63-66
33173030-7	2020	The present study thus reveals CCK-mediated neural mechanisms in the central nervous system for the control of water-intake behaviors.	Water	111-116	cholecystokinin	Homo sapiens	31-34
33168815-1	2020	Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide (H2O2) that is expressed in various epithelial cells and in macrophages.	Water	39-44	aquaporin 3	Mus musculus	0-11
32721729-12	2020	In addition, the removal rate of total N-DBP precursors may be higher than that of TFP, leading to overly optimistic evaluation of precursor removal in water treatment practice.	Water	152-157	D-box binding PAR bZIP transcription factor	Homo sapiens	41-44
33168815-1	2020	Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide (H2O2) that is expressed in various epithelial cells and in macrophages.	Water	39-44	aquaporin 3	Mus musculus	13-17
32946198-1	2020	A naturally occurring water-soluble cobalt-complex, cyanocobalamin (Vitamin B12)  has been identified as a new and efficient electrocatalyst for the CO 2 -to-CO reduction reaction in aqueous solution.	Water	22-27	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	76-79
32946198-4	2020	This method follows an ecofriendly and sustainable approach with the involvement of water as an electrolyte with biodegradable and non-toxic chemicals/materials like B12 , GO and CP.	Water	84-89	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	166-169
33172142-7	2020	DFT calculations and a Monte Carlo simulation were utilized to predict the active reactivity sites of AST and calculate the lowest adsorption energy and configuration of AST alone and AST + iodide on/Fe (110)/water interface.	Water	209-214	solute carrier family 17 member 5	Homo sapiens	170-173
33172142-7	2020	DFT calculations and a Monte Carlo simulation were utilized to predict the active reactivity sites of AST and calculate the lowest adsorption energy and configuration of AST alone and AST + iodide on/Fe (110)/water interface.	Water	209-214	solute carrier family 17 member 5	Homo sapiens	170-173
33027691-5	2020	Structural differences involving extensive water-mediated hydrogen bond networks could be correlated to functional data to understand how PF 06882961, but not CHU-128, can closely mimic the pharmacological properties of GLP-1.	Water	43-48	glucagon	Homo sapiens	220-225
33085450-11	2020	Based on the fog-capturing ability of the hydrophilic areas and the water transport performance of the hydrophobic regions, efficient fog harvesting was achieved.	Water	68-73	zinc finger protein, FOG family member 1	Homo sapiens	13-16
33085450-11	2020	Based on the fog-capturing ability of the hydrophilic areas and the water transport performance of the hydrophobic regions, efficient fog harvesting was achieved.	Water	68-73	zinc finger protein, FOG family member 1	Homo sapiens	134-137
32986435-9	2020	Overall, water-solubility of lyophilized Que-Me-beta-CD and Que-HP-beta-CD products was approximately 7-40 times and 14-50 times as higher as for pure Quercetin at pH 1.2-6.8.	Water	9-14	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	48-55
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	6-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	6-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-212
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-212
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-212
33076661-4	2020	IR measurements of a series of the CN-deficient PBAs after the catalytic reactions clarified that a part of the NH3 ligands remained on [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and that hydrogen phosphate formed as a product strongly adsorbed on the FeII ions of [GaIII(H2O)][FeII(CN)5(NH3)].	Water	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
33076661-4	2020	IR measurements of a series of the CN-deficient PBAs after the catalytic reactions clarified that a part of the NH3 ligands remained on [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and that hydrogen phosphate formed as a product strongly adsorbed on the FeII ions of [GaIII(H2O)][FeII(CN)5(NH3)].	Water	263-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
32986435-9	2020	Overall, water-solubility of lyophilized Que-Me-beta-CD and Que-HP-beta-CD products was approximately 7-40 times and 14-50 times as higher as for pure Quercetin at pH 1.2-6.8.	Water	9-14	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	67-74
33136434-1	2020	In this study, we prepared gelatin-coated mesoporous hollow silica nanospheres (GSN) as a drug carrier to improve the water solubility and regulate the release rate of glimepiride (GLM).	Water	118-123	gelsolin	Rattus norvegicus	80-83
33328060-4	2020	Vasodilation also results in activation of the renin-angiotensin-aldosterone axis, which combined with changing tubular handling causes alterations in total body stores of electrolytes and total body water, resulting in a lower serum sodium concentration.	Water	200-205	renin	Homo sapiens	47-52
31931659-12	2020	Collectively, our results identify ROS as central inducers of MTORC2 activation during chronic autophagy, which in turn fuels senescence activation and myofibroblast differentiation in distinct cellular subpopulations.Abbreviations: 3-MA: 3-methyladenine; ACTA2: actin, alpha 2, smooth muscle, aorta; AKT1: AKT serine/threonine kinase 1; p-AKT1: AKT1 Ser473 phosphorylation; t-AKT1: total AKT serine/threonine kinase 1; ATG4A: autophagy related 4A cysteine peptidase; ATG7: autophagy gene 7; C12FDG: 5-dodecanoylaminofluorescein Di-beta-D-Galactopyranoside; CDKN1A: cyclin dependent kinase inhibitor 1A; CDKN2A: cyclin dependent kinase inhibitor 2A; Ctl: control; DAPI: 4",6-diamidino-2-phenylindole, dilactate; ECM: extracellular matrix; GSH: L-glutathione reduced; H2O2: hydrogen peroxide; HLF: adult human lung fibroblasts; Ho: Hoechst 33342 (2"-[4-ethoxyphenyl]-5-[4-methyl-1-piperazinyl]-2.5"-bi-1H-benzimidazole); HSC: hepatic stellate cells; LY: LY294002; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTORC1/2: mechanistic target of rapamycin kinase complex 1/2; N: normal growth medium; NAC: N-acetyl-L-cysteine; PBS: phosphate-buffered saline; PDGFA: platelet derived growth factor subunit A; PRKCA/PKCalpha: protein kinase C alpha; PtdIns3K: class III phosphatidylinositol 3-kinase; PTEN: phosphatase and tensin homolog; R: rapamycin; RICTOR: RPTOR independent companion of MTOR complex 2; ROS: reactive oxygen species; RPTOR: regulatory associated protein of MTOR complex 1; SA-GLB1/beta-gal: senescence-associated galactosidase beta 1; SGK1: serum/glucocorticoid regulated kinase 1; shRNA: short hairpin RNA; siCtl: control siRNA; siRNA: small interfering RNA; SQSTM1: sequestosome 1; SS: serum-free (serum starvation) medium; TP53: tumor protein p53; TUBA: tubulin alpha; V: vehicle.	Water	767-771	mechanistic target of rapamycin kinase	Homo sapiens	62-66
33137850-5	2021	RESULTS: Screening procedure of Radix Polygoni Multiflori water extract against human serum albumin (HSA) was used as an example, to discuss and verify the detailed methodology.	Water	58-63	albumin	Homo sapiens	86-99
32539474-6	2020	After adjusting for demographic and HIV variables, IL-6 and d-dimer remained associated with lack of electricity and having an unprotected water source only in PHIVs (p<0.019).	Water	139-144	interleukin 6	Homo sapiens	51-55
33152901-0	2020	Water extract of sporoderm-broken spores of Ganoderma lucidum enhanced pd-l1 antibody efficiency through downregulation and relieved complications of pd-l1 monoclonal antibody.	Water	0-5	CD274 antigen	Mus musculus	71-76
33152901-0	2020	Water extract of sporoderm-broken spores of Ganoderma lucidum enhanced pd-l1 antibody efficiency through downregulation and relieved complications of pd-l1 monoclonal antibody.	Water	0-5	CD274 antigen	Mus musculus	150-155
32554006-11	2020	When unwashed syringe filters were used for a real water sample, the DBP formation increased by up to 73.2% compared to the pre-washed ones; particularly for TCNM it was always over 15%.	Water	51-56	D-box binding PAR bZIP transcription factor	Homo sapiens	69-72
33040230-9	2020	Plasma VTG presented elevated levels in fish exposed to water samples collected at the two sites in close proximity to on-site systems and during seasons with low stream discharge, though the levels observed did not suggest severe endocrine disruption.	Water	56-61	LOC100136735	Oncorhynchus mykiss	7-10
32554023-0	2020	Mechanism investigation and stable isotope change during photochemical degradation of tetrabromobisphenol A (TBBPA) in water under LED white light irradiation.	Water	119-124	small integral membrane protein 10 like 2A	Homo sapiens	131-134
32590178-0	2020	Corn derivative mesoporous carbon microspheres supported hydrophilic polydopamine for development of new membrane: Water treatment containing bovine serum albumin.	Water	115-120	albumin	Homo sapiens	149-162
31050602-7	2020	Even if the MBGLS was composed of tap water, NO and SO2, the removal efficiencies of NO and SO2 respectively reached 78% and 94.4%.	Water	38-43	SEC14 like lipid binding 2	Homo sapiens	34-37
32590178-3	2020	The results were then applied to treat double-distilled water containing bovine serum albumin (BSA) utilizing a cross-module set-up.	Water	56-61	albumin	Homo sapiens	80-93
32593811-6	2020	The membrane fabricated using 50% NMP/water as the bore fluid mixture exhibited the highest water flux of 166.98 LMH with a bovine serum albumin rejection rate of more than 97%.	Water	38-43	albumin	Homo sapiens	131-144
32623637-2	2020	Recent findings from animal studies suggest a role of GLP-1 in drinking and water homeostasis.	Water	76-81	glucagon	Homo sapiens	54-59
31284807-10	2020	Changes in plasma midkine levels were also associated with extravascular lung water index (P = .063) and pulmonary vascular permeability index (P = .049).	Water	78-83	midkine	Homo sapiens	18-25
32750556-10	2020	So, the content of 152Eu and 241Am radionuclides are intensively released into the water: from 0 to 198 +- 8 Bq L-1 and 167 +- 7 Bq L-1, respectively.	Water	83-88	L1 cell adhesion molecule	Homo sapiens	112-135
32840695-0	2020	PGC-1alpha alternative promoter (Exon 1b) controls augmentation of total PGC-1alpha gene expression in response to cold water immersion and low glycogen availability.	Water	120-125	PPARG coactivator 1 alpha	Homo sapiens	0-10
32840695-0	2020	PGC-1alpha alternative promoter (Exon 1b) controls augmentation of total PGC-1alpha gene expression in response to cold water immersion and low glycogen availability.	Water	120-125	PPARG coactivator 1 alpha	Homo sapiens	73-83
32840695-1	2020	This investigation sought to determine whether post-exercise cold water immersion and low glycogen availability, separately and in combination, would preferentially activate either the Exon 1a or Exon 1b Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) promoter.	Water	66-71	PPARG coactivator 1 alpha	Homo sapiens	204-272
32840695-1	2020	This investigation sought to determine whether post-exercise cold water immersion and low glycogen availability, separately and in combination, would preferentially activate either the Exon 1a or Exon 1b Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) promoter.	Water	66-71	PPARG coactivator 1 alpha	Homo sapiens	274-284
32840695-6	2020	Importantly, this increase in PGC-1alpha Exon 1b expression was reduced compared to the response of low glycogen or cold water immersion alone, suggesting that the combination of prior low glycogen and CWI post-exercise impaired the response in gene expression versus these conditions individually.	Water	121-126	PPARG coactivator 1 alpha	Homo sapiens	30-40
32827513-1	2020	In fishes, Prl signaling underlies the homeostatic regulation of hydromineral balance by controlling essential solute and water transporting functions performed by the gill, gastrointestinal tract, kidney, urinary bladder, and integument.	Water	122-127	prolactin	Homo sapiens	11-14
32827513-2	2020	Comparative studies spanning over 60 years have firmly established that Prl promotes physiological activities that enable euryhaline and stenohaline teleosts to reside in freshwater environments; nonetheless, the specific molecular and cellular targets of Prl in ion- and water-transporting tissues are still being resolved.	Water	176-181	prolactin	Homo sapiens	72-75
32593472-3	2020	Ifng-/-Il17a-/- mice were fully susceptible to EAU with a characteristic eosinophilic ocular infiltrate, as opposed to a mononuclear infiltrate in WT mice.	Water	47-50	interferon gamma	Mus musculus	0-4
32593472-5	2020	In EAU-challenged Ifng-/-Il17a-/- mice, ocular infiltrates contained increased GM-CSF-producing CD4+ T cells, and supernatants of retinal antigen-stimulated splenocytes contained enhanced levels of GM-CSF that contributed to activation and migration of eosinophils in vitro.	Water	3-6	interferon gamma	Mus musculus	18-22
32593472-6	2020	Systemic or local blockade of GM-CSF ameliorated EAU in Ifng-/-Il17a-/- mice, reduced eosinophil peroxidase levels in the eye and in the serum and decreased eosinophil infiltration to the eye.	Water	49-52	interferon gamma	Mus musculus	56-60
32698056-11	2020	The ammonium content in the pore water (up to 5.34 mg L-1) was much higher than the limit for drinking water of 0.5 mg L-1 in China.	Water	33-38	L1 cell adhesion molecule	Homo sapiens	54-57
32705563-4	2020	Here, the release behavior of DBP from PVC plastic pipe fragments was investigated in water environment under different conditions.	Water	86-91	D-box binding PAR bZIP transcription factor	Homo sapiens	30-33
32064985-4	2020	In this study, we sought to test the hypothesis that oxidative stress injury in ischemic brains and H2O2-treated mouse neuroblastoma Neuro-2a cells (N2a) was related to STAT3 activation.	Water	100-104	signal transducer and activator of transcription 3	Mus musculus	169-174
32673858-0	2020	Judicious fabrication of bifunctionalized graphene oxide/MnFe2O4 magnetic nanohybrids for enhanced removal of Pb(II) from water.	Water	122-127	submaxillary gland androgen regulated protein 3B	Homo sapiens	110-116
33361042-7	2020	The results of the reverse transcriptase polymerase chain reaction, Western blot, and immunohistochemical staining confirmed the expression of AQP-1, a kind of transmembrane protein that mainly distributed in the membranes of pulmonary cells and contributed to maintain water balance in the body by interacting with tumor necrosis factor-alpha (TNF-alpha), is negatively associated with APALI.	Water	270-275	aquaporin 1 (Colton blood group)	Homo sapiens	143-148
32707599-7	2020	The optimized method was applied to tap and surface waters; two anti-inflammatory drugs were detected at the ng L-1 level in surface water.	Water	52-57	L1 cell adhesion molecule	Homo sapiens	112-115
32853485-9	2020	The ROCK2, PMVK, ADCY2, MAP2K6, BMP10 and GFPT1 genes are main candidates for reproductive traits in water dairy buffaloes and, these results may have future applications in animal breeding programs or in gene expression studies of the species.	Water	101-106	phosphomevalonate kinase	Bubalus bubalis	11-15
32812807-1	2020	BACKGROUND: The most profound effect of vasopressin on the kidney is to increase water reabsorption through V2-receptor (V2R) stimulation, but there are also data suggesting effects on calcium transport.	Water	81-86	arginine vasopressin	Rattus norvegicus	40-51
32739638-9	2020	These interactions play the role of a network at the entrance of the enzyme active site and prevent the penetration of water molecules into the PLA2 cavity.	Water	119-124	phospholipase A2 group IB	Homo sapiens	144-148
33254514-8	2020	These medications are readily available and testing this theory involves determination of the correct dosage of angiotensin receptor blockers or ACE inhibitors (via dilution in water) that can be used as nasal lavage and performing efficacy trials.	Water	177-182	angiotensin I converting enzyme	Homo sapiens	145-148
32394964-7	2020	Our results revealed that water-based programs modulated antioxidant enzyme activity, increased superoxide dismutase activity, reduced catalase activity, and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson"s disease.	Water	26-31	catalase	Homo sapiens	135-143
32394964-7	2020	Our results revealed that water-based programs modulated antioxidant enzyme activity, increased superoxide dismutase activity, reduced catalase activity, and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson"s disease.	Water	26-31	catalase	Homo sapiens	214-222
32888908-7	2020	The C3 carboxylate is placed where the deacylation water occupies in the apo-enzyme, which, together with the displacement of the catalytic base residue at position 150, explains why carbapenems are poor substrates of ACC-1.	Water	51-56	BCL2 related protein A1	Homo sapiens	218-223
33194843-8	2020	There was some variation between the human isolates, but the water isolate seemed to display the greatest pathogenic potential, demonstrated by the highest levels of virulence gene expression, adhesion to epithelial cells and IL-8 induction.	Water	61-66	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
33121486-5	2020	Using an unbiased analysis of gene expression in the dorsal hippocampus after training in the Morris water maze or contextual fear conditioning, we discovered dysregulation of CREB, CLOCK, and BMAL1 target genes and downregulation of circadian genes in CBPKIX/KIX mice.	Water	101-106	cAMP responsive element binding protein 1	Mus musculus	176-180
33121486-5	2020	Using an unbiased analysis of gene expression in the dorsal hippocampus after training in the Morris water maze or contextual fear conditioning, we discovered dysregulation of CREB, CLOCK, and BMAL1 target genes and downregulation of circadian genes in CBPKIX/KIX mice.	Water	101-106	circadian locomotor output cycles kaput	Mus musculus	182-187
32898419-7	2020	Meanwhile, the radioexcited conduction band electrons react with high-level H2O2 within cancer cells to yield more ROS, and the secondary electrons are trapped by H2O molecules to produce hydrated electrons capable of reducing highly oxidized species such as cytochrome c.	Water	76-79	cytochrome c, somatic	Homo sapiens	259-271
33103958-1	2020	Vitamin B12, a water-soluble vitamin, plays a vital role in the formation of hematopoietic stem cells and has been associated with oral mucosal diseases, mainly recurrent aphthous stomatitis (RAS).	Water	15-20	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
32945658-6	2020	The interactions inhibiting heme dissociation were then seen to be (i) either a direct or a water molecule mediated interaction between distal histidine and heme iron; and (ii) stacking between heme and the alphaCE1/betaCD1 phenylalanine residue.	Water	92-97	angiotensin I converting enzyme	Homo sapiens	207-223
33120873-2	2020	They are closely interconnected in the catabolism of reactive oxygen species because one product of SOD reaction (hydrogen peroxide) is the main substrate of CAT reaction finally leading to harmless products (i.e., molecular oxygen and water).	Water	236-241	superoxide dismutase 1	Homo sapiens	100-103
33114088-5	2020	It was demonstrated that the storage modulus of CF/PC composites with hot water aged for seven days has the highest value in this sampling period and frequency.	Water	74-79	pyruvate carboxylase	Homo sapiens	48-53
32835483-5	2020	Application of this code to the bovine pancreatic trypsin inhibitor protein reproduces three buried crystallographic water sites that are poorly sampled using conventional molecular dynamics.	Water	117-122	trophoblast Kunitz domain protein 1	Bos taurus	50-67
33114759-0	2020	Bismuth Subcarbonate Decorated Reduced Graphene Oxide Nanocomposite for the Sensitive Stripping Voltammetry Analysis of Pb(II) and Cd(II) in Water.	Water	141-146	submaxillary gland androgen regulated protein 3B	Homo sapiens	120-126
33114244-4	2020	Here, we investigate the persistence of an extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) pEK499 and its clinically most important ARG (blaCTX-M-15), after introduction via irrigation water or manure into a lettuce-growing system.	Water	214-219	EsbL	Escherichia coli	43-75
33120734-2	2020	Vitamin B12 (B12), water-soluble vitamins, are a cofactor in DNA synthesis and involved in the metabolism of every cell in the human body, including the central nervous system.	Water	19-24	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
33120734-2	2020	Vitamin B12 (B12), water-soluble vitamins, are a cofactor in DNA synthesis and involved in the metabolism of every cell in the human body, including the central nervous system.	Water	19-24	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	13-16
33021369-2	2020	The mesh netting used by current fog harvesters suffers from inefficient drainage, which severely constrains the water collection efficiency.	Water	113-118	zinc finger protein, FOG family member 1	Homo sapiens	33-36
33090341-5	2020	Correctness and performance tests show that the implemented SP2 is accurate and fast, as the GPU is able to achieve speedups up to 40 times for a water cluster system with 42,312 orbitals running in one NVIDIA K40 GPU card compared to the single-threaded version.	Water	146-151	Sp2 transcription factor	Homo sapiens	60-63
32760982-11	2020	For C18 (aqueous) UHPLC-MS urine analysis, 50 : 50 methanol : water had high reproducibility and yield.	Water	62-67	Bardet-Biedl syndrome 9	Homo sapiens	4-7
33021369-3	2020	Recently, it was demonstrated that fog harps can significantly enhance water harvesting as the vertical wire array does not obstruct the drainage pathway.	Water	71-76	zinc finger protein, FOG family member 1	Homo sapiens	35-38
33021369-7	2020	On average, the fog harps collected about three times more water than the mesh netting.	Water	59-64	zinc finger protein, FOG family member 1	Homo sapiens	16-19
33021369-8	2020	During fog harvesting, the harp wires were observed to tangle together due to the surface tension of water.	Water	101-106	zinc finger protein, FOG family member 1	Homo sapiens	7-10
33142371-7	2020	Compared with the blank control group, the expression levels of the oncogenes c-fos, c-myc, k-ras and the apoptosis genes Caspase-3, Caspase-8 and Caspase-9 increased, the expression level of tumor suppressor gene p53 decreased in the L02 hepatocyte group treated with PM(2.5) water soluble matter, and the differences were statistically significant (P<0.05) .	Water	277-282	caspase 3	Homo sapiens	122-131
33092263-4	2020	The proline adduct was the most active compound, it showed anti-leukemic activity, upregulated heme oxygenase 1 (HMOX1) and the primary stress-inducible isoform of the heath shock 70 kDa protein 1 (HSPA1A), and downregulated NFkB1 transcription, it was also found to be about 270 times more water soluble than dehydroleucodine.	Water	291-296	heat shock protein family A (Hsp70) member 1A	Homo sapiens	198-204
33023288-5	2020	The maximum quantum yield for photocatalytic H2 evolution from tetrachlorohydroquinone (Cl4QH2) with Acr+-Mes and CoIII(dmgH)2pyCl and H2O in deaerated MeCN was determined to be 10%.	Water	135-138	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	114-119
33086710-0	2020	Protein-Stabilized Palm-Oil-in-Water Emulsification Using Microchannel Array Devices under Controlled Temperature.	Water	31-36	paralemmin	Homo sapiens	19-23
32996765-4	2020	All the ThO2 nH2O samples prepared presented amounts of residual carbon and water in the range 0.2-0.3 wt % and n   0.5, respectively.	Water	76-81	THO complex 2	Homo sapiens	8-12
32996507-4	2020	For the stepwise mechanism which consists of the formation of H2O-CoIII-OH, the ring-opening of PO and propylene glycol formation, our studies reveal that different H2O-CoIII-Xs behave kinetically very similarly in the course of propylene glycol formation, but show a notable difference in the rate of H2O-CoIII-OH formation with Cl- > OAc- > OTs-.	Water	165-168	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	66-71
32829141-0	2020	Sub/supercritical fluid chromatography employing water-rich modifier enables the purification of biosynthesized human insulin.	Water	49-54	insulin	Homo sapiens	118-125
33068167-1	2020	A novel electrochemical carbon cloth (CC) analysis device (eCAD) is proposed for the determination of Pb2+ in environmental water samples, which was assembled using a single-step functional CC as both the sensing and the substrate material.	Water	124-129	cadherin 1	Homo sapiens	59-63
33209348-7	2020	The asymmetric unit of the complex is comprised of half the pyridine ring and water mol-ecule with the CoII atom at the center of the pincer situated about a twofold axis.	Water	78-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-107
32739347-1	2020	A reversible fluorescence probe for acetylcholinesterase activity detection was developed based on water soluble perylene derivative, N,N"-di(2-aspartic acid)-perylene-3,4,9,10-tetracarboxylic diimide (PASP).	Water	99-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-56
32996507-3	2020	For the eight concerted routes, the cooperative bimetallic route in which the middle carbon atom is attacked by the nucleophilic oxygen atom (route VI-m) was calculated to be the most favorable, and among the three catalysts examined H2O-CoIII-OTs was found to be the most active, due to the strong hydrogen bonding between the nucleophilic H2O and the ring oxygen atom in the epoxides as well as the extra pi-pi stacking interaction.	Water	234-237	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	238-243
32996507-3	2020	For the eight concerted routes, the cooperative bimetallic route in which the middle carbon atom is attacked by the nucleophilic oxygen atom (route VI-m) was calculated to be the most favorable, and among the three catalysts examined H2O-CoIII-OTs was found to be the most active, due to the strong hydrogen bonding between the nucleophilic H2O and the ring oxygen atom in the epoxides as well as the extra pi-pi stacking interaction.	Water	341-344	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	238-243
32996507-4	2020	For the stepwise mechanism which consists of the formation of H2O-CoIII-OH, the ring-opening of PO and propylene glycol formation, our studies reveal that different H2O-CoIII-Xs behave kinetically very similarly in the course of propylene glycol formation, but show a notable difference in the rate of H2O-CoIII-OH formation with Cl- > OAc- > OTs-.	Water	62-65	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	66-71
32996507-4	2020	For the stepwise mechanism which consists of the formation of H2O-CoIII-OH, the ring-opening of PO and propylene glycol formation, our studies reveal that different H2O-CoIII-Xs behave kinetically very similarly in the course of propylene glycol formation, but show a notable difference in the rate of H2O-CoIII-OH formation with Cl- > OAc- > OTs-.	Water	62-65	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	169-174
32996507-4	2020	For the stepwise mechanism which consists of the formation of H2O-CoIII-OH, the ring-opening of PO and propylene glycol formation, our studies reveal that different H2O-CoIII-Xs behave kinetically very similarly in the course of propylene glycol formation, but show a notable difference in the rate of H2O-CoIII-OH formation with Cl- > OAc- > OTs-.	Water	165-168	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	169-174
32996507-4	2020	For the stepwise mechanism which consists of the formation of H2O-CoIII-OH, the ring-opening of PO and propylene glycol formation, our studies reveal that different H2O-CoIII-Xs behave kinetically very similarly in the course of propylene glycol formation, but show a notable difference in the rate of H2O-CoIII-OH formation with Cl- > OAc- > OTs-.	Water	62-65	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	169-174
32996507-4	2020	For the stepwise mechanism which consists of the formation of H2O-CoIII-OH, the ring-opening of PO and propylene glycol formation, our studies reveal that different H2O-CoIII-Xs behave kinetically very similarly in the course of propylene glycol formation, but show a notable difference in the rate of H2O-CoIII-OH formation with Cl- > OAc- > OTs-.	Water	165-168	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	169-174
32996507-4	2020	For the stepwise mechanism which consists of the formation of H2O-CoIII-OH, the ring-opening of PO and propylene glycol formation, our studies reveal that different H2O-CoIII-Xs behave kinetically very similarly in the course of propylene glycol formation, but show a notable difference in the rate of H2O-CoIII-OH formation with Cl- > OAc- > OTs-.	Water	165-168	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	66-71
32996507-4	2020	For the stepwise mechanism which consists of the formation of H2O-CoIII-OH, the ring-opening of PO and propylene glycol formation, our studies reveal that different H2O-CoIII-Xs behave kinetically very similarly in the course of propylene glycol formation, but show a notable difference in the rate of H2O-CoIII-OH formation with Cl- > OAc- > OTs-.	Water	165-168	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	169-174
32996507-4	2020	For the stepwise mechanism which consists of the formation of H2O-CoIII-OH, the ring-opening of PO and propylene glycol formation, our studies reveal that different H2O-CoIII-Xs behave kinetically very similarly in the course of propylene glycol formation, but show a notable difference in the rate of H2O-CoIII-OH formation with Cl- > OAc- > OTs-.	Water	165-168	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	169-174
32739696-3	2020	However, little information has been known about the effect of conventional water treatment processes on DBP formation when rainwater is used as drinking water source.	Water	76-81	D-box binding PAR bZIP transcription factor	Homo sapiens	105-108
32739696-3	2020	However, little information has been known about the effect of conventional water treatment processes on DBP formation when rainwater is used as drinking water source.	Water	128-133	D-box binding PAR bZIP transcription factor	Homo sapiens	105-108
32739696-4	2020	This study evaluated CX3R-type DBP precursors removal from rainwater by conventional drinking water treatments and the corresponding decrease of CX3R-type DBP (trihalomethanes (THMs), haloaldehydes (HALs), haloacetonitriles (HANs) and haloacetamides (HAMs)) formation and toxicity during the subsequent chlor(am)ination.	Water	63-68	D-box binding PAR bZIP transcription factor	Homo sapiens	31-34
32818735-0	2020	Removal of micropollutants in drinking water using UV-LED/chlorine advanced oxidation process followed by activated carbon adsorption.	Water	39-44	small integral membrane protein 10 like 2A	Homo sapiens	54-57
32818735-7	2020	The UV-LED/chlorine AOP followed by GAC adsorption provides a multi-barrier treatment system for enhancing micropollutant removal in potable water.	Water	141-146	small integral membrane protein 10 like 2A	Homo sapiens	7-10
32758789-8	2020	Water extracts were more active in zebrafish PXR compared to human PXR whereas the opposite was observed for PPARgamma.	Water	0-5	nuclear receptor subfamily 1, group I, member 2	Danio rerio	45-48
32758789-8	2020	Water extracts were more active in zebrafish PXR compared to human PXR whereas the opposite was observed for PPARgamma.	Water	0-5	nuclear receptor subfamily 1 group I member 2	Homo sapiens	67-70
32777598-1	2020	The European Union has proposed the value of 1 ng L-1 as a drinking water quality standard for estradiol.	Water	68-73	L1 cell adhesion molecule	Homo sapiens	50-53
33057107-4	2020	The anti-inflammatory activities of water extract and individual compounds were screened by NF-kappaB and interferon regulatory factor (IRF) reporter assays in THP-1 cells induced with either Toll-like receptor or retinoic acid inducible gene I/melanoma differentiation-associated gene 5 activators and further verified in bone marrow-derived macrophages.	Water	36-41	nuclear factor kappa B subunit 1	Homo sapiens	92-101
33090513-0	2020	Water-soluble fraction of particulate matter <2.5 mum promoted lung epithelia cells apoptosis by regulating the expression of caveolin-1 and Kruppel-like factor 5.	Water	0-5	caveolin 1	Homo sapiens	126-136
33090513-3	2020	In the present study, we found that exposure of A549 cells to the water-soluble fraction of PM2.5 (WS-PM2.5) promoted the expression and internalization of caveolin-1.	Water	66-71	caveolin 1	Homo sapiens	156-166
33057107-5	2020	MDP water extract significantly inhibited the activation of NF-kappaB and IRF reporters, downstream signaling pathways and the production of IL-6 and TNF-alpha, in a dose-dependent manner.	Water	4-9	nuclear factor kappa B subunit 1	Homo sapiens	60-69
33057107-5	2020	MDP water extract significantly inhibited the activation of NF-kappaB and IRF reporters, downstream signaling pathways and the production of IL-6 and TNF-alpha, in a dose-dependent manner.	Water	4-9	interleukin 6	Homo sapiens	141-145
33057107-5	2020	MDP water extract significantly inhibited the activation of NF-kappaB and IRF reporters, downstream signaling pathways and the production of IL-6 and TNF-alpha, in a dose-dependent manner.	Water	4-9	tumor necrosis factor	Homo sapiens	150-159
33046708-0	2020	Triple isotope variations of monthly tap water in China.	Water	41-46	SEC14 like lipid binding 2	Homo sapiens	37-40
32996499-2	2020	As observed by TEM, SEM and AFM imaging, the self-assembly of NDI-BIM 1 produced irregular nanostructures at neutral pH in CH3CN-H2O (1 : 1); whereas, well-defined nanotubes were observed at pH 2.	Water	129-132	arginine vasopressin receptor 2	Homo sapiens	62-71
33046708-1	2020	Tap water isotopic compositions could potentially record information on local climate and water management practices.	Water	4-9	SEC14 like lipid binding 2	Homo sapiens	0-3
33046708-1	2020	Tap water isotopic compositions could potentially record information on local climate and water management practices.	Water	90-95	SEC14 like lipid binding 2	Homo sapiens	0-3
33046708-3	2020	Detailed data records of tap water 17O-excess have not been reported.	Water	29-34	SEC14 like lipid binding 2	Homo sapiens	25-28
33046708-4	2020	In this report, monthly tap water samples (n = 652) were collected from December 2014 to November 2015 from 92 collection sites across China.	Water	28-33	SEC14 like lipid binding 2	Homo sapiens	24-27
33046708-5	2020	The isotopic composition (delta2H, delta18O, and delta17O) of tap water was analyzed by a Triple Water Vapor Isotope Analyzer (T-WVIA) based on Off-Axis Integrated Cavity Output Spectroscopy (OA-ICOS) technique and two second-order isotopic variables (d-excess and 17O-excess) were calculated.	Water	66-71	SEC14 like lipid binding 2	Homo sapiens	62-65
33046708-7	2020	This report presents national-scale tap water isotope dataset at monthly time scale.	Water	40-45	SEC14 like lipid binding 2	Homo sapiens	36-39
33046708-8	2020	Researchers and water resource managers who focus on the tap water issues could use them to probe the water source and water management strategies at large spatial scales.	Water	16-21	SEC14 like lipid binding 2	Homo sapiens	57-60
33046708-8	2020	Researchers and water resource managers who focus on the tap water issues could use them to probe the water source and water management strategies at large spatial scales.	Water	61-66	SEC14 like lipid binding 2	Homo sapiens	57-60
33046708-8	2020	Researchers and water resource managers who focus on the tap water issues could use them to probe the water source and water management strategies at large spatial scales.	Water	61-66	SEC14 like lipid binding 2	Homo sapiens	57-60
33046708-8	2020	Researchers and water resource managers who focus on the tap water issues could use them to probe the water source and water management strategies at large spatial scales.	Water	61-66	SEC14 like lipid binding 2	Homo sapiens	57-60
33025573-7	2021	Similar results were obtained in mice, in which administrated CORT in drinking water for 21 days significantly impaired the GR levels in the mitochondria, while Bag-1 overexpression rescued this reduction.	Water	79-84	nuclear receptor subfamily 3, group C, member 1	Mus musculus	124-126
32993871-8	2020	Upon successful application to fresh water, TML and TEL were only presented in the river water whereas Pb(II) was only existed in the tap water, along with accuracy validation by good spiked recoveries (93-106%).	Water	89-94	ETS variant transcription factor 6	Homo sapiens	52-55
32993871-8	2020	Upon successful application to fresh water, TML and TEL were only presented in the river water whereas Pb(II) was only existed in the tap water, along with accuracy validation by good spiked recoveries (93-106%).	Water	89-94	ETS variant transcription factor 6	Homo sapiens	52-55
32985177-3	2020	Evidently, by adorning TPE and pyrene units in [2]rotaxanes P1, P2, P1-b, and P2-b, they display remarkable emission bands in 70% of water fraction (fw) in tetrahydrofuran (THF)/water mixture, which could be attributed to the restricted intramolecular rotation of phenyl groups, whereas prominent blue-shifted excimer emission of pyrene started to appear as fw reached 80% for P1 and 90% for P1-b, P2, and P2-b, which was ascribed to the favorable pi-pi stacking and hydrophobic interactions of the pyrene rings that enabled their static excimer formation.	Water	133-138	trefoil factor 3	Homo sapiens	68-72
32985177-3	2020	Evidently, by adorning TPE and pyrene units in [2]rotaxanes P1, P2, P1-b, and P2-b, they display remarkable emission bands in 70% of water fraction (fw) in tetrahydrofuran (THF)/water mixture, which could be attributed to the restricted intramolecular rotation of phenyl groups, whereas prominent blue-shifted excimer emission of pyrene started to appear as fw reached 80% for P1 and 90% for P1-b, P2, and P2-b, which was ascribed to the favorable pi-pi stacking and hydrophobic interactions of the pyrene rings that enabled their static excimer formation.	Water	178-183	trefoil factor 3	Homo sapiens	68-72
32985177-3	2020	Evidently, by adorning TPE and pyrene units in [2]rotaxanes P1, P2, P1-b, and P2-b, they display remarkable emission bands in 70% of water fraction (fw) in tetrahydrofuran (THF)/water mixture, which could be attributed to the restricted intramolecular rotation of phenyl groups, whereas prominent blue-shifted excimer emission of pyrene started to appear as fw reached 80% for P1 and 90% for P1-b, P2, and P2-b, which was ascribed to the favorable pi-pi stacking and hydrophobic interactions of the pyrene rings that enabled their static excimer formation.	Water	178-183	trefoil factor 3	Homo sapiens	392-396
32526422-4	2020	The total Hg (THg) concentration of surface water in the KRB ranged from 0.64 to 32.96 ng L-1 with an average of 5.83 +- 6.19 ng L-1 and decreased in the order of post-monsoon (8.79 +- 7.32 ng L-1) > monsoon (6.68 +- 6.12 ng L-1) > pre-monsoon (2.18 +- 1.29 ng L-1).	Water	44-49	L1 cell adhesion molecule	Homo sapiens	90-93
33163009-0	2020	MdbHLH130, an Apple bHLH Transcription Factor, Confers Water Stress Resistance by Regulating Stomatal Closure and ROS Homeostasis in Transgenic Tobacco.	Water	55-60	basic helix-loop-helix protein A	Malus domestica	20-45
32878902-10	2020	Under Na+-deplete conditions GAD65-ChR2-EYFP mice displayed a robust preference for H2O illuminated with 470 nm light versus nonilluminated H2O, suggesting that type I glial-like TBCs are sufficient for driving a behavior that resembles Na+ appetite.SIGNIFICANCE STATEMENT This is the first investigation on the role of type I GAD65+ taste bud cells (TBCs) in taste-mediated physiology and behavior via optogenetics.	Water	84-87	glutamic acid decarboxylase 2	Mus musculus	29-34
32878902-10	2020	Under Na+-deplete conditions GAD65-ChR2-EYFP mice displayed a robust preference for H2O illuminated with 470 nm light versus nonilluminated H2O, suggesting that type I glial-like TBCs are sufficient for driving a behavior that resembles Na+ appetite.SIGNIFICANCE STATEMENT This is the first investigation on the role of type I GAD65+ taste bud cells (TBCs) in taste-mediated physiology and behavior via optogenetics.	Water	140-143	glutamic acid decarboxylase 2	Mus musculus	29-34
32878902-13	2020	Na+-depleted mice showed robust preferences to "light taste" (H2O illuminated with 470 nm light vs nonilluminated H2O), suggesting that the activation of GAD65+ cells may generate a salt-taste sensation in the brain.	Water	62-65	glutamic acid decarboxylase 2	Mus musculus	154-159
32846092-1	2020	The growing use of silver-based nanoparticles (Ag-b-NPs) in everyday products goes in hand with their release into the environment, resulting in ng L-1 traces in natural water bodies.	Water	170-175	L1 cell adhesion molecule	Homo sapiens	148-151
32878902-13	2020	Na+-depleted mice showed robust preferences to "light taste" (H2O illuminated with 470 nm light vs nonilluminated H2O), suggesting that the activation of GAD65+ cells may generate a salt-taste sensation in the brain.	Water	114-117	glutamic acid decarboxylase 2	Mus musculus	154-159
33036320-1	2020	We report results on the translational dynamics of the hydration water of the lysozyme protein upon cooling obtained by means of molecular dynamics simulations.	Water	65-70	lysozyme	Homo sapiens	78-86
32544662-10	2020	Similarly, the adsorption capacity obtained using Taihu lake water and Bohai seawater as matrices was much lower than that using laboratory water for both DCP and TCP, while the adsorption coefficient (Kd) of MCP remained at approximately 10.6 L/kg to 11.4 L/kg in the three different solution matrices.	Water	61-66	CD46 molecule	Homo sapiens	209-212
32969214-4	2020	This study provides the first account of how CoII imine based supramolecules can be employed as H2O oxidation catalysts.	Water	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
32876723-3	2020	The proposed beta-CD-CuNCs exhibited excellent water solubility, ultrafine size, good dispersion, bright photoluminescence, and good photostability.	Water	47-52	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	13-20
32534481-1	2020	OBJECTIVE: Arginine vasopressin (AVP) is released upon osmotic stimulation or hypovolemia in order to maintain water balance.	Water	111-116	arginine vasopressin	Homo sapiens	11-31
33083227-6	2020	MET25 deficient Y. lipolytica could be used as an efficient whole-cell lead sensor with detection limit as low as 10 ppm of lead in drinking water.	Water	141-146	bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17	Saccharomyces cerevisiae S288C	0-5
32693667-9	2020	These results suggest that PIP2;1 plays a negative role in light-induced stomatal opening, and phosphorylation of PIP2;1 at Ser-280 and Ser-283 causes reduced water absorption in guard cells and decreased stomatal opening.	Water	159-164	plasma membrane intrinsic protein 1A	Arabidopsis thaliana	27-33
32693667-9	2020	These results suggest that PIP2;1 plays a negative role in light-induced stomatal opening, and phosphorylation of PIP2;1 at Ser-280 and Ser-283 causes reduced water absorption in guard cells and decreased stomatal opening.	Water	159-164	plasma membrane intrinsic protein 1A	Arabidopsis thaliana	114-120
32562941-4	2020	Those pPt-PEG NPs are able to produce reactive oxygen species (ROS) by triggering water decomposition under electric field, independent of O2 and H2O2 contents in the tumor.	Water	82-87	tachykinin precursor 1	Homo sapiens	6-9
32823055-4	2020	Especially, four water molecules can saturate hydrate site AI and while more water molecules will be required to saturate hydrate sites AIII and AII.	Water	17-22	NLR family pyrin domain containing 3	Homo sapiens	136-139
32823055-4	2020	Especially, four water molecules can saturate hydrate site AI and while more water molecules will be required to saturate hydrate sites AIII and AII.	Water	77-82	NLR family pyrin domain containing 3	Homo sapiens	136-139
32572739-1	2020	This study was conducted to optimize the preparation of fungal-algal pellets for use in the removal of arsenite (As(III)) and arsenate (As(V)) from water.	Water	148-153	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	135-141
32544662-10	2020	Similarly, the adsorption capacity obtained using Taihu lake water and Bohai seawater as matrices was much lower than that using laboratory water for both DCP and TCP, while the adsorption coefficient (Kd) of MCP remained at approximately 10.6 L/kg to 11.4 L/kg in the three different solution matrices.	Water	80-85	CD46 molecule	Homo sapiens	209-212
32619914-7	2020	RESULTS: Water, hair and nail arsenic concentrations showed significant positive associations with FBG, serum insulin and HOMA-IR and inverse associations with serum creatinine and LBM in a dose-dependent manner both in males and females.	Water	9-14	insulin	Homo sapiens	110-117
32544662-11	2020	The Kd values exhibited using natural water matrices consistently followed the order of DCP > MCP > TCP.	Water	38-43	CD46 molecule	Homo sapiens	94-97
32905063-5	2020	Se-treated rats received 0.3 mg/l sodium selenite in drinking water.	Water	62-67	squalene epoxidase	Rattus norvegicus	0-2
32794261-4	2020	Our results showed that iNOS mice displayed a comparable levels of basal transepidermal water loss rates, stratum corneum hydration and skin surface pH to their wild type mice, but epidermal permeability barrier recovery was significantly delayed both 2 and 4 hours after acute barrier disruption by tape-stripping.	Water	88-93	nitric oxide synthase 2, inducible	Mus musculus	24-28
32497668-1	2020	The influence of a wide spectrum of water-miscible organic cosolvents at different concentrations on the denaturation of hen egg-white lysozyme is studied using differential scanning calorimetry (DSC) and circular dichroism (CD).	Water	36-41	lysozyme	Homo sapiens	135-143
32683063-1	2020	OBJECTIVE: To perform a pilot study of short-term safety, tolerability, and impact on urinary stone risk parameters of the vasopressin V2-receptor antagonist tolvaptan (which increases urinary excretion of free water) among adolescents and young adults with cystinuria.	Water	211-216	arginine vasopressin receptor 2	Homo sapiens	123-146
32945437-8	2020	The results revealed that Nitrodi spring water promoted cell migration and cell viability, and downregulated protein S-nitrosylation, probably also the nitrosylated active form of the cyclooxygenase (COX)-2 protein.	Water	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-206
32600722-4	2020	The synthesized SA/bFGF@pNIPAM/DS@p(NIPAM-co-AA) hydrogel presented a desirable storage modulus of ~4500 Pa, a high water equilibrium swelling ratio of ~90, an appropriate water vapor transmission rate of ~2300 g/m2/day, and nontoxicity to human skin fibroblasts.	Water	116-121	fibroblast growth factor 2	Homo sapiens	19-23
32600722-4	2020	The synthesized SA/bFGF@pNIPAM/DS@p(NIPAM-co-AA) hydrogel presented a desirable storage modulus of ~4500 Pa, a high water equilibrium swelling ratio of ~90, an appropriate water vapor transmission rate of ~2300 g/m2/day, and nontoxicity to human skin fibroblasts.	Water	172-177	fibroblast growth factor 2	Homo sapiens	19-23
32415147-11	2020	By contrast, aquaretic drugs (such as vasopressin antagonists) predominantly cause water excretion, which increases the osmolality of the circulating blood, potentially improving translocation of fluid from the tissues to the circulation and thereby relieving tissue congestion.	Water	83-88	arginine vasopressin	Homo sapiens	38-49
33004854-9	2020	Our data further indicate that STAT3 pathway modulates interactions between B and T cells during EAU resulting in alteration of lymphocyte repertoire by increasing levels of autoreactive pathogenic T cells while suppressing development and/or expansion of immune-suppressive lymphocytes (Bregs and Tregs).	Water	97-100	signal transducer and activator of transcription 3	Mus musculus	31-36
32222974-0	2020	Water-soluble variant of human Lynx1 positively modulates synaptic plasticity and ameliorates cognitive impairment associated with alpha7-nAChR dysfunction.	Water	0-5	Ly6/neurotoxin 1	Homo sapiens	31-36
32222974-2	2020	Previously, we demonstrated that at low micromolar concentrations the water-soluble Lynx1 variant lacking GPI-anchor (ws-Lynx1) acts on alpha7-nAChRs as a positive allosteric modulator.	Water	70-75	Ly6/neurotoxin 1	Mus musculus	84-89
32222974-2	2020	Previously, we demonstrated that at low micromolar concentrations the water-soluble Lynx1 variant lacking GPI-anchor (ws-Lynx1) acts on alpha7-nAChRs as a positive allosteric modulator.	Water	70-75	Ly6/neurotoxin 1	Mus musculus	121-126
33077138-2	2020	AQP1, AQP3 and AQP5 are isoforms of aquaporin known to aid in transepithelial water movement.	Water	78-83	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
32957133-3	2020	We present the case of an individual who suffered AGE while breathing compressed air at 1.2 metres" fresh water (mfw) in a swimming pool and discuss the factors determining the depth at which this form of injury may occur.	Water	106-111	renin binding protein	Homo sapiens	50-53
33350272-9	2020	The water extract of LFH can significantly reduce the content of inflammatory factors in rats with ALI, and down-regulate the mRNA expression of TNFAIP3, IL1 R1, IL6 R and NFKBIA in the lung tissues, showing significant anti-inflammatory effect.	Water	4-9	interleukin 1 receptor type 1	Rattus norvegicus	154-160
33350272-9	2020	The water extract of LFH can significantly reduce the content of inflammatory factors in rats with ALI, and down-regulate the mRNA expression of TNFAIP3, IL1 R1, IL6 R and NFKBIA in the lung tissues, showing significant anti-inflammatory effect.	Water	4-9	interleukin 6 receptor	Rattus norvegicus	162-167
33134276-2	2020	However, their optical performance will seriously decline once they are wetted by water droplets (such as fog, dew, and rain droplets) or are polluted by contaminations in a humid environment.	Water	82-87	zinc finger protein, FOG family member 1	Homo sapiens	106-109
33083505-2	2020	This article presents molecular dynamics (MD) trajectories of water solution of three protein-ligand complexes smoothened-beta-sitosterol (SMO-BST), smoothened-sonidegib (SMO-SNG) and smoothened-cholesterol (SMO-CLR) using CHARMM36 and SPC/E water model combination.	Water	62-67	surfactant protein C	Homo sapiens	236-239
32979923-8	2020	The BBB permeability in TDP-43 overexpressing brains yielded the frontal cortex vulnerable to the systemic inflammatory response following LPS treatment, leading to marked neutrophil infiltration, neuronal loss, reduced synaptosome-associated protein 25 (SNAP-25) levels, and behavioral impairments in the radial arm water maze (RAWM) task.	Water	317-322	TAR DNA binding protein	Mus musculus	24-30
32882136-1	2020	We demonstrate the assembly into a compact, gel-like Langmuir-Blodgett films of rods formed by self-assembly of a beta-sheet-forming water-soluble peptide, Ac-IKHLSVN-NH2 at the surface of aqueous electrolytes.	Water	133-138	amyloid beta precursor protein	Homo sapiens	112-118
33133067-8	2020	C-IRIS mice also exhibited brain swelling with resemblance to edema and upregulation of aquaporin-4, a critical protein that regulates water flux in the brain in a Th1-dependent fashion.	Water	135-140	negative elongation factor complex member C/D, Th1l	Mus musculus	164-167
32856030-6	2020	Density functional theory results demonstrate that NiP3 shows a stronger water adsorption energy than CeO2.	Water	73-78	BCL2 interacting protein 3	Homo sapiens	51-55
33029488-8	2020	Aminoacyl-tRNA biosynthesis, metabolic pathways, and vasopressin-regulated water reabsorption were significantly enriched in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway network, suggesting that these pathways may play key roles in CMT occurrence and development.	Water	75-80	arginine vasopressin	Homo sapiens	53-64
32852017-1	2020	Collisions of He2+, Li3+ and C3+ ions with water molecules are studied at energies ranging between 20 keV u-1 and 500 keV u-1.	Water	43-48	cytochrome P450 family 4 subfamily F member 22	Homo sapiens	20-23
32892621-2	2020	The reactivity of dtbp-H toward two different calcium sources has been found to vary significantly, e.g., the reaction of Ca(OMe)2 with dtbp-H in a 1:6 molar ratio in petroleum ether forms a mononuclear calcium hexa-phosphate complex [Ca(dtbp)2(dtbp-H)4] (1), whereas the change of calcium source to CaH2, in a 1:2 molar ratio under otherwise similar reaction conditions, yields the calcium phosphate polymer, [Ca(mu-dtbp)2(H2O)2 H2O]n(2).	Water	424-427	amyloid beta precursor protein	Homo sapiens	6-7
32892621-2	2020	The reactivity of dtbp-H toward two different calcium sources has been found to vary significantly, e.g., the reaction of Ca(OMe)2 with dtbp-H in a 1:6 molar ratio in petroleum ether forms a mononuclear calcium hexa-phosphate complex [Ca(dtbp)2(dtbp-H)4] (1), whereas the change of calcium source to CaH2, in a 1:2 molar ratio under otherwise similar reaction conditions, yields the calcium phosphate polymer, [Ca(mu-dtbp)2(H2O)2 H2O]n(2).	Water	424-427	amyloid beta precursor protein	Homo sapiens	28-29
32892621-2	2020	The reactivity of dtbp-H toward two different calcium sources has been found to vary significantly, e.g., the reaction of Ca(OMe)2 with dtbp-H in a 1:6 molar ratio in petroleum ether forms a mononuclear calcium hexa-phosphate complex [Ca(dtbp)2(dtbp-H)4] (1), whereas the change of calcium source to CaH2, in a 1:2 molar ratio under otherwise similar reaction conditions, yields the calcium phosphate polymer, [Ca(mu-dtbp)2(H2O)2 H2O]n(2).	Water	424-427	amyloid beta precursor protein	Homo sapiens	28-29
32892621-2	2020	The reactivity of dtbp-H toward two different calcium sources has been found to vary significantly, e.g., the reaction of Ca(OMe)2 with dtbp-H in a 1:6 molar ratio in petroleum ether forms a mononuclear calcium hexa-phosphate complex [Ca(dtbp)2(dtbp-H)4] (1), whereas the change of calcium source to CaH2, in a 1:2 molar ratio under otherwise similar reaction conditions, yields the calcium phosphate polymer, [Ca(mu-dtbp)2(H2O)2 H2O]n(2).	Water	430-433	amyloid beta precursor protein	Homo sapiens	6-7
32892621-2	2020	The reactivity of dtbp-H toward two different calcium sources has been found to vary significantly, e.g., the reaction of Ca(OMe)2 with dtbp-H in a 1:6 molar ratio in petroleum ether forms a mononuclear calcium hexa-phosphate complex [Ca(dtbp)2(dtbp-H)4] (1), whereas the change of calcium source to CaH2, in a 1:2 molar ratio under otherwise similar reaction conditions, yields the calcium phosphate polymer, [Ca(mu-dtbp)2(H2O)2 H2O]n(2).	Water	430-433	amyloid beta precursor protein	Homo sapiens	28-29
32892621-2	2020	The reactivity of dtbp-H toward two different calcium sources has been found to vary significantly, e.g., the reaction of Ca(OMe)2 with dtbp-H in a 1:6 molar ratio in petroleum ether forms a mononuclear calcium hexa-phosphate complex [Ca(dtbp)2(dtbp-H)4] (1), whereas the change of calcium source to CaH2, in a 1:2 molar ratio under otherwise similar reaction conditions, yields the calcium phosphate polymer, [Ca(mu-dtbp)2(H2O)2 H2O]n(2).	Water	430-433	amyloid beta precursor protein	Homo sapiens	28-29
32892621-11	2020	Solution decomposition of either 1 or 2 in boiling toluene at 140  C in a sealed tube produces calcium dihydrogen phosphate [Ca(H2PO4)2 H2O] as the only product in the form of single crystals.	Water	136-139	amyloid beta precursor protein	Homo sapiens	59-60
32956406-1	2020	Aquaporins (AQP) are a family of plasma membrane proteins responsible for water transport through cell membranes.	Water	74-79	AQP	Apis mellifera	0-10
32956406-1	2020	Aquaporins (AQP) are a family of plasma membrane proteins responsible for water transport through cell membranes.	Water	74-79	AQP	Apis mellifera	12-15
33036527-8	2020	After c-myc silenced cells were treated with PM2.5 water soluble solution, The mRNA levels of c-myc, c-fos, and k-ras decreased by 84.1%, 45.4%, and 54.6% (P<0.05) , p53 increased by 192.9% (P<0.05) , and the expression of Caspase-3, Caspase-8, and Caspase-9 decreased by 24.4%, 36.1%, 60.9% (P<0.05) .	Water	51-56	tumor protein p53	Homo sapiens	166-169
32961653-4	2020	Subsequent reaction of HL1 and HL2 with CuCl2 2H2O in 1:1 molar ratio in methanol produced the complexes [CuII(HL1)Cl2] H2O (1 H2O) and [CuII(HL2)Cl2] (2).	Water	47-50	asialoglycoprotein receptor 1	Homo sapiens	23-26
32961653-4	2020	Subsequent reaction of HL1 and HL2 with CuCl2 2H2O in 1:1 molar ratio in methanol produced the complexes [CuII(HL1)Cl2] H2O (1 H2O) and [CuII(HL2)Cl2] (2).	Water	47-50	asialoglycoprotein receptor 1	Homo sapiens	111-114
32961653-4	2020	Subsequent reaction of HL1 and HL2 with CuCl2 2H2O in 1:1 molar ratio in methanol produced the complexes [CuII(HL1)Cl2] H2O (1 H2O) and [CuII(HL2)Cl2] (2).	Water	120-123	asialoglycoprotein receptor 1	Homo sapiens	23-26
32961653-4	2020	Subsequent reaction of HL1 and HL2 with CuCl2 2H2O in 1:1 molar ratio in methanol produced the complexes [CuII(HL1)Cl2] H2O (1 H2O) and [CuII(HL2)Cl2] (2).	Water	120-123	asialoglycoprotein receptor 1	Homo sapiens	111-114
33036527-8	2020	After c-myc silenced cells were treated with PM2.5 water soluble solution, The mRNA levels of c-myc, c-fos, and k-ras decreased by 84.1%, 45.4%, and 54.6% (P<0.05) , p53 increased by 192.9% (P<0.05) , and the expression of Caspase-3, Caspase-8, and Caspase-9 decreased by 24.4%, 36.1%, 60.9% (P<0.05) .	Water	51-56	caspase 3	Homo sapiens	223-232
32948764-3	2020	The controlled installation of N-CH3, -CDH2, -CD2H, -CD3, and -13CH3 groups into pharmaceutical amines thus has been demonstrated by tuning isotopic water and methanol.	Water	149-154	cardiomyopathy, dilated 1F (autosomal dominant)	Homo sapiens	46-68
32957634-5	2020	Here, we report the identification of several DYRK1A inhibitors using our in-house topological water network-based approach.	Water	95-100	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	46-52
32936175-3	2020	Here, by means of first-principles calculations within the quasi-particle approximation and the Bethe-Salpeter equation, we demonstrated a unique framework of triphenylenes (sp2) and acetylenic linkages (sp), namely triphenyldiyne (TDY) that has the electronic band structure suitable for photocatalytic overall water splitting along with pronounced optical absorbance in visible light.	Water	312-317	Sp2 transcription factor	Homo sapiens	174-177
32840539-3	2020	The notable differences are (a) the binding mode of the tridentate part of polypyridyl ligands to the Co(ii) center is facial in 1a, 3a and 4a but meridional in 2a, (b) the Co(ii) centers in 1a-3a are hexacoordinated (with a coordinated water in 1a and 3a) but are pentacoordinated in 4a, and (c) the binding mode of tdc linker is bis(monodentate) in 1a, 3a and 4a but chelated in one end and monodentate in the other end in 2a.	Water	237-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
33123363-1	2020	Background: The antidiuretic hormone (ADH) or arginine vasopressin (AVP) regulates the body"s water balance.	Water	94-99	arginine vasopressin	Homo sapiens	16-36
33123363-1	2020	Background: The antidiuretic hormone (ADH) or arginine vasopressin (AVP) regulates the body"s water balance.	Water	94-99	arginine vasopressin	Homo sapiens	38-41
33123363-1	2020	Background: The antidiuretic hormone (ADH) or arginine vasopressin (AVP) regulates the body"s water balance.	Water	94-99	arginine vasopressin	Homo sapiens	55-66
33123363-1	2020	Background: The antidiuretic hormone (ADH) or arginine vasopressin (AVP) regulates the body"s water balance.	Water	94-99	arginine vasopressin	Homo sapiens	68-71
32361092-2	2020	It was found that the water holding capacity, gel strength, and viscoelasticity of SPI gel were improved with the increase of WBC concentration.	Water	22-27	chromogranin A	Homo sapiens	83-86
32672383-3	2020	Based on the 1 H NMR data and molecular dynamics simulations, we found that two distinct complexes with different stoichiometry, i.e., guest@beta-CD and guest@beta-CD 2 , coexist in equilibrium in a water solution of the ( Z )-stilbene-based guests.	Water	199-204	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	141-148
32962254-1	2020	Cystic fibrosis (CF), a lethal hereditary disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene coding for an epithelial chloride channel, is characterized by an imbalanced homeostasis of ion and water transports in secretory epithelia.	Water	241-246	CF transmembrane conductance regulator	Homo sapiens	77-128
32841310-1	2020	A new water-soluble tri-tert-butyl-bithiophenesulfonamide (alpha2-tbS) was synthesized and a comprehensive spectroscopic and photophysical study was undertaken in organic solvents and water at different pH values.	Water	6-11	glycoprotein hormone subunit alpha 2	Homo sapiens	59-65
32841310-1	2020	A new water-soluble tri-tert-butyl-bithiophenesulfonamide (alpha2-tbS) was synthesized and a comprehensive spectroscopic and photophysical study was undertaken in organic solvents and water at different pH values.	Water	184-189	glycoprotein hormone subunit alpha 2	Homo sapiens	59-65
32325181-0	2020	The water extract of "Jiao Mei Gu" attenuates the lipopolysaccharide-induced inflammatory response via inhibiting NF-kappaB activity in mice.	Water	4-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	114-123
32460100-3	2020	As a consequence, the resultant YS Ru@HMCS, delivers a high LA conversion (99.4%), a large selectivity to GVL (99.9%), and prolonged cycling life (up to 9 cycles) under water towards the LA hydrogenation, that exceeds conventional yolk-structured and supported analogues.	Water	169-174	MKKS centrosomal shuttling protein	Homo sapiens	38-42
32325181-19	2020	CONCLUSIONS: Our results showed that a water-soluble extract of JMG inhibited LPS-induced inflammation via attenuating the NF-kappaB signaling pathway, which provides an important rationale for the treatment of inflammation-related diseases.	Water	39-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132
32805840-6	2020	By contrast, the modified surface decorated with moderately hydrophilic amino groups combines the advantages of biological surfaces with distinct wetting features (such as fog-harvesting beetles and water-repellent lotus leaves), resulting in accelerated water nucleation and less compromise of water removal efficiency.	Water	255-260	zinc finger protein, FOG family member 1	Homo sapiens	172-175
32622948-0	2020	Phospholipase Cbeta3 in the hippocampus may mediate impairment of memory by long-term blockade of orexin 1 receptors assessed by the Morris water maze.	Water	140-145	hypocretin neuropeptide precursor	Rattus norvegicus	98-104
32828321-6	2020	On the other hand, mice fed with DMB drinking water showed lower TMAO level, interleukin (IL)-1beta and IL-6, and higher vascular endothelial growth factor in the ischemic muscle, and better perfusion recovery after experimental PAD.	Water	46-51	interleukin 6	Mus musculus	104-108
32805840-6	2020	By contrast, the modified surface decorated with moderately hydrophilic amino groups combines the advantages of biological surfaces with distinct wetting features (such as fog-harvesting beetles and water-repellent lotus leaves), resulting in accelerated water nucleation and less compromise of water removal efficiency.	Water	255-260	zinc finger protein, FOG family member 1	Homo sapiens	172-175
32811144-5	2020	By treating simulated wastewater six times with this material, the PFOA concentration in water was reduced from 1 ppm to 43 ppt (43 ng L-1), showing that PR-PEG-PFA is a promising adsorbent for PFASs separation, recovery, and recycling.	Water	27-32	L1 cell adhesion molecule	Homo sapiens	135-138
32995104-2	2020	We propose that pyramiding AVP1 and MIOX4 genes will further improve stress tolerance under water-limited and salt-stress conditions.	Water	92-97	myo-inositol oxygenase 4	Arabidopsis thaliana	36-41
32891383-6	2020	Additionally, the coulometric response shows acceptable and reliable results for detection of NO3- in mineral water as compared to the traditional potentiometric response and the ion chromatography.	Water	110-115	NBL1, DAN family BMP antagonist	Homo sapiens	94-97
32899830-0	2020	Evaluation of Antioxidant and Anti-Inflammatory Activity of Anthocyanin-Rich Water-Soluble Aronia Dry Extracts.	Water	77-82	DDB1 and CUL4 associated factor 7	Homo sapiens	60-71
33124281-8	2020	Based on the cluster analysis results, the groundwater was divided into four categories (A1, A2, B1, and B2), of which A1 was highly mineralized by Cl-Na type water, while A2, B1, and B2 were mainly HCO3  Cl  SO4-Na and HCO3-Na type water.	Water	49-54	BCL2 related protein A1	Homo sapiens	89-99
33124281-8	2020	Based on the cluster analysis results, the groundwater was divided into four categories (A1, A2, B1, and B2), of which A1 was highly mineralized by Cl-Na type water, while A2, B1, and B2 were mainly HCO3  Cl  SO4-Na and HCO3-Na type water.	Water	49-54	ATPase H+ transporting V0 subunit a2	Homo sapiens	93-107
32315938-0	2020	TLR4-MyD88 signaling pathway is responsible for acute lung inflammation induced by reclaimed water.	Water	93-98	toll-like receptor 4	Mus musculus	0-4
32315938-5	2020	In addition, conditional knockout of the Tlr4 gene in myeloid cells resulted in a significant reduction of sensitivity to the reclaimed water in mutants, which indicates that myeloid cells play the most important role in the defensive immune system against the pollutants in the water.	Water	136-141	toll-like receptor 4	Mus musculus	41-45
32315938-5	2020	In addition, conditional knockout of the Tlr4 gene in myeloid cells resulted in a significant reduction of sensitivity to the reclaimed water in mutants, which indicates that myeloid cells play the most important role in the defensive immune system against the pollutants in the water.	Water	279-284	toll-like receptor 4	Mus musculus	41-45
32315938-6	2020	In general, this study demonstrated that the TLR4-MyD88 signaling pathway is responsible for the acute lung inflammation induced by reclaimed water, which excludes the possibility of other signaling pathway dependent inflammation inducers in reclaimed water.	Water	142-147	toll-like receptor 4	Mus musculus	45-49
33177919-3	2020	Activated corin cleaves pro-ANP to ANP, which regulates water-sodium balance and lowers blood pressure.	Water	56-61	corin, serine peptidase	Mus musculus	10-15
32887288-2	2020	The water extract of WB inhibited degranulation and expression of allergic and inflammatory mediators such as tumor necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase in antigen-stimulated RBL-2H3 cells.	Water	4-9	tumor necrosis factor	Rattus norvegicus	110-137
32887288-2	2020	The water extract of WB inhibited degranulation and expression of allergic and inflammatory mediators such as tumor necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase in antigen-stimulated RBL-2H3 cells.	Water	4-9	nitric oxide synthase 2	Rattus norvegicus	160-191
32865852-3	2020	We hypothesized that both lines would show evidence of front-loading during binge EtOH access and that we would find a cSNC effect in groups where EtOH was replaced with water, as these results have been shown previously in HAP1 mice.	Water	170-175	huntingtin-associated protein 1	Mus musculus	224-228
32330590-6	2020	In addition, water intake was consistently lower in mice kept on LabDiet 5001 (Diet 2 (LD5001)), and occasionally in mice kept on Teklad Diet 7012 (Diet 3 (H7012)), compared to the Teklad Diet 2918 (Diet 1 (H2918)) group.	Water	13-18	Malrd1	Mus musculus	199-205
32535182-7	2020	At the behavioural level, after three weeks of treatment, the anti-LINGO-1 group displayed significantly more platform crossings in the Morris water maze than the CS standard group.	Water	143-148	leucine rich repeat and Ig domain containing 1	Rattus norvegicus	67-74
31818185-10	2020	CASP9 expression or exogenously added H2O2 in the CASP9 KO cells corrected the ATG3 level and lipidation status of Atg8-family members, and restored autophagy flux.	Water	38-42	GABA type A receptor associated protein like 1	Homo sapiens	115-119
33222764-1	2020	In primary polydipsia pathologically high levels of water intake physiologically lower arginine vasopressin (AVP) secretion, and in this way mirror the secondary polydipsia in diabetes insipidus in which pathologically low levels of AVP (or renal responsiveness to AVP) physiologically increase water intake.	Water	52-57	arginine vasopressin	Homo sapiens	96-107
32413638-0	2020	Selective, highly efficient extraction of Cr(III), Pb(II) and Fe(III) from complex water environment with a tea residue derived porous gel adsorbent.	Water	83-88	submaxillary gland androgen regulated protein 3B	Homo sapiens	51-57
32506784-1	2020	In recent years, the diagnosis of brain tumors has been investigated with attenuated total reflection - Fourier transform infrared (ATR-FTIR) spectroscopy on dried human serum samples to eliminate spectral interferences of the water component, with promising results.	Water	227-232	ATR serine/threonine kinase	Homo sapiens	132-135
32375090-4	2020	Results showed that concentrations of individual PAHs in the surface water ranged from less than the limit of quantification (LOQ) to 949 ng L-1, indicating a reduction of PAH contamination level after the implementation of environmental management actions.	Water	69-74	L1 cell adhesion molecule	Homo sapiens	141-144
32416392-7	2020	We demonstrated that novel nanocomposite materials MOF-d-SMNP/GO and MOF-d-SMNP/O-SWCNT showed potential for water treatment and gas sorption applications.	Water	109-114	SMNP	Homo sapiens	57-61
32416392-7	2020	We demonstrated that novel nanocomposite materials MOF-d-SMNP/GO and MOF-d-SMNP/O-SWCNT showed potential for water treatment and gas sorption applications.	Water	109-114	SMNP	Homo sapiens	51-61
32449613-3	2020	Instead, irradiation generates the IR700 radical anion, leading to acid-base reactions with nearby water molecules (i. e., calculated pKb for the radical anion is 7.7) to produce hydrophobic ligand-released dyes.	Water	99-104	AKT serine/threonine kinase 1	Homo sapiens	134-137
32812959-7	2020	Furthermore, complexation of L1 with Cu(BF4)2 H2O and Zn(CF3SO3)2 provided a 2D   3D interpenetrated network containing a classic dimeric copper paddle-wheel SBU, and an infinite 1D chain which extended into a 3D structure facilitated by hydrogen-bonding interactions, respectively.	Water	46-49	L1 cell adhesion molecule	Homo sapiens	29-31
32557067-2	2020	Five random forest (RF) models are developed to estimate these parameters in Xin"anjiang Reservoir, which is a clear drinking water resource in Zhejiang, China.	Water	126-131	xin actin binding repeat containing 1	Homo sapiens	77-80
32634698-8	2020	Elevated miR-27a or reduced HSP90 diminished water content, neuronal apoptosis and infarct volume, suppressed oxidative stress and inflammatory response, as well as improved neurological deficits and pathological damages.	Water	45-50	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	28-33
32619897-4	2020	Normal mode analysis (NMA) of SOD1 demonstrates how collective domain motion influences key residues of the electrostatic loop (ESL), guiding substrate to the active site and facilitating the delivery of the conserved water network necessary for proton transfer.	Water	218-223	superoxide dismutase 1	Homo sapiens	30-34
32993437-10	2020	Anodized surfaces modified by reactive plasma and stored in DI water suggest better hydrophilicity stability, biocompatibility, ALP activity and achievement of crystalline phase alteration, indicating future potential use on biomedical implants.	Water	63-68	alkaline phosphatase, placental	Homo sapiens	128-131
32585402-11	2020	CONCLUSIONS: In summary, the water-soluble ION-PP-TZ is a promising bimodal agent for the diagnosis and treatment of human epidermal growth factor receptor 2-positive breast cancer cells using a T2 MRI contrast agent and photothermal therapy.	Water	29-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	123-157
32817533-1	2020	The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel is essential for epithelial salt-water balance.	Water	110-115	CF transmembrane conductance regulator	Homo sapiens	4-55
32817533-1	2020	The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel is essential for epithelial salt-water balance.	Water	110-115	CF transmembrane conductance regulator	Homo sapiens	57-61
32817533-3	2020	In cells CFTR is activated through the cAMP signaling pathway, overstimulation of which during cholera leads to CFTR-mediated intestinal salt-water loss.	Water	142-147	CF transmembrane conductance regulator	Homo sapiens	9-13
32665334-8	2020	Overall, our results suggest that the response to water stress implies the activation of wax biosynthesis and the involvement of both ZmFDL1/MYB94 and abscisic acid regulatory pathways.	Water	50-55	Transcription factor MYB96	Zea mays	141-146
32817533-3	2020	In cells CFTR is activated through the cAMP signaling pathway, overstimulation of which during cholera leads to CFTR-mediated intestinal salt-water loss.	Water	142-147	CF transmembrane conductance regulator	Homo sapiens	112-116
32639685-0	2020	A novel mutation in PDE6B in Spanish Water Dogs with early-onset progressive retinal atrophy.	Water	37-42	phosphodiesterase 6B	Canis lupus familiaris	20-25
32669036-2	2020	Here, we aim to identify genes specifically or commonly regulated by D14 and KAI2 under water scarcity, using comparative analysis of the transcriptome data of the A. thaliana d14-1 and kai2-2 mutants under dehydration conditions.	Water	88-93	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	77-81
32669036-4	2020	These results suggest that cytokinin and brassinosteroid metabolism might be specifically regulated by the D14 pathway, whereas photosynthesis and metabolism of glucosinolates and trehalose are potentially regulated by both D14 and KAI2 pathways in plant response to water scarcity.	Water	267-272	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	232-236
32720036-8	2020	Thus, we have introduced a reversible prodrug strategy that enables water solubility and in vivo activity of masked A3AR agonists in models of two disease conditions.	Water	68-73	adenosine A3 receptor	Mus musculus	116-120
32446062-6	2020	This study, by providing a rich dataset on water quantity and quality and by quantifying the importance of the hydrological regime on DOC transport, represents an important step toward a quantitative modeling of the Arno River.	Water	43-48	cytohesin 2	Homo sapiens	216-220
32857786-12	2020	A slightly lower C18:2 content was found in the water bath samples than in the control groups (-0.11%, p = 0.0430).	Water	48-53	Bardet-Biedl syndrome 9	Homo sapiens	17-20
32574822-7	2020	Therefore, UV/chlorine treatment may achieve good quality water with reduced DBP-associated toxicity in freshwater or iodide-containing water (iodide only), but careful consideration is needed when purifying source waters containing bromide (bromide only), especially for AOM/bromide-containing water.	Water	109-114	D-box binding PAR bZIP transcription factor	Homo sapiens	77-80
32574822-7	2020	Therefore, UV/chlorine treatment may achieve good quality water with reduced DBP-associated toxicity in freshwater or iodide-containing water (iodide only), but careful consideration is needed when purifying source waters containing bromide (bromide only), especially for AOM/bromide-containing water.	Water	109-114	D-box binding PAR bZIP transcription factor	Homo sapiens	77-80
32618114-10	2020	Compared with the control mice, antibody-treated EAU mice showed few CD11c+ CD40+ DC and CD11c+ CD40+ MHC-II+ DC frequencies in splenocytes.	Water	49-52	histocompatibility-2, MHC	Mus musculus	102-108
32867720-1	2020	BACKGROUND: Concentration of the urine is primarily regulated via vasopressin dependent aquaporin-2 water channels in the apical membrane of kidney principal cells.	Water	100-105	arginine vasopressin	Homo sapiens	66-77
32797817-4	2020	This manuscript reports an approach for PFAS analysis which uses subsampling of water matrices from vessels including centrifuge tubes and autosampler vials, through the optimized use of solvent to reduce PFAS retention on subsampling vessels.	Water	80-85	phosphoribosylformylglycinamidine synthase	Homo sapiens	40-44
32574822-4	2020	The DBP yields in HA-containing water during UV/chlorination decreased in the order of iodide loaded > freshwater >> bromide loaded, whereas DBP formation in AOM-containing water decreased remarkably with halides added (freshwater > bromide loaded >> iodide loaded) at high UV fluence.	Water	32-37	D-box binding PAR bZIP transcription factor	Homo sapiens	4-7
32574822-4	2020	The DBP yields in HA-containing water during UV/chlorination decreased in the order of iodide loaded > freshwater >> bromide loaded, whereas DBP formation in AOM-containing water decreased remarkably with halides added (freshwater > bromide loaded >> iodide loaded) at high UV fluence.	Water	108-113	D-box binding PAR bZIP transcription factor	Homo sapiens	4-7
32983200-0	2020	Physiological and PIP Transcriptional Responses to Progressive Soil Water Deficit in Three Mulberry Cultivars.	Water	68-73	prolactin induced protein	Homo sapiens	18-21
33005610-3	2020	In this work, the soybean hulls after the SBP extraction, destined to become a putrescible waste, were recovered and employed as adsorbents for water remediation due to their cellulose-based composition.	Water	144-149	sucrose-binding protein 2	Glycine max	42-45
32736708-9	2020	miR-182-5p mimic therapy in transplanted Th17 cells ameliorated EAU severity in vivo.	Water	64-67	microRNA 182	Mus musculus	0-7
32434784-9	2020	From ceca and water, potential ESBL E. coli were only confirmed from MacConkey agar with 4 mug/ml cefotaxime, where 45% and 16.6% of E. coli isolates phenotypically expressed ESBL-production.	Water	14-19	EsbL	Escherichia coli	31-35
32858981-6	2020	The experiment has shown that by discarding noisy bands adjacent to the SOM features, and the removal of the water absorption bands, the determination coefficient of prediction (Rp2) and the ratio of prediction to deviation (RPD) for the prediction of SOM from moist soil have achieved Rp2 = 0.92 and the RPD = 3.19, both of which are about 5% better than that of using all bands for building the PLSR model.	Water	109-114	RP2 activator of ARL3 GTPase	Homo sapiens	178-181
32673289-5	2020	Moreover, single nucleus RNA sequencing determined that epithelial HDAC1 and HDAC2 are necessary for expression of many sodium or water transporters and channels.	Water	130-135	histone deacetylase 2	Mus musculus	77-82
32833955-12	2020	Moreover, the H2O2-induced downregulation of E-cadherin expression, increased ROS generation, and ERK activation in 16HBE cells were restored by treatment with QXT water or ethanol extract.	Water	164-169	cadherin 1	Homo sapiens	45-55
32833955-12	2020	Moreover, the H2O2-induced downregulation of E-cadherin expression, increased ROS generation, and ERK activation in 16HBE cells were restored by treatment with QXT water or ethanol extract.	Water	164-169	mitogen-activated protein kinase 1	Homo sapiens	98-101
32275985-5	2020	(2015) showed that aortic ECs express the water channel protein aquaporin-1 (AQP1) and the transEC (deltaP) portion of the transmural (DeltaP) pressure difference drives, in parallel, water across AQP1s and plasma across interEC junctions.	Water	42-47	aquaporin 1 (Colton blood group)	Homo sapiens	64-75
32275985-5	2020	(2015) showed that aortic ECs express the water channel protein aquaporin-1 (AQP1) and the transEC (deltaP) portion of the transmural (DeltaP) pressure difference drives, in parallel, water across AQP1s and plasma across interEC junctions.	Water	42-47	aquaporin 1 (Colton blood group)	Homo sapiens	77-81
32275985-5	2020	(2015) showed that aortic ECs express the water channel protein aquaporin-1 (AQP1) and the transEC (deltaP) portion of the transmural (DeltaP) pressure difference drives, in parallel, water across AQP1s and plasma across interEC junctions.	Water	184-189	aquaporin 1 (Colton blood group)	Homo sapiens	64-75
32275985-5	2020	(2015) showed that aortic ECs express the water channel protein aquaporin-1 (AQP1) and the transEC (deltaP) portion of the transmural (DeltaP) pressure difference drives, in parallel, water across AQP1s and plasma across interEC junctions.	Water	184-189	aquaporin 1 (Colton blood group)	Homo sapiens	77-81
32275985-6	2020	Since the lumen is isotonic, selective AQP1-mediated water flow should quickly render the ECs" lumen side hypertonic and the SI hypotonic; resulting transEC oncotic pressure differences, deltapi, should oppose deltaP and quickly halt transEC flow.	Water	53-58	aquaporin 1 (Colton blood group)	Homo sapiens	39-43
32905448-2	2020	In this contribution, a simple water-soluble ESIPT fluorescent probe 2-((4-((tert-butyldiphenylsilyl)oxy)-1,3-dioxoisoindolin-2-yl)methyl)-1-ethylpyridin-1-ium iodide (SPI) was constructed for monitoring fluoride ion.	Water	31-36	chromogranin A	Homo sapiens	168-171
32846909-5	2020	Cutaneous exposure to OVA and PM10 alone resulted in a significant increase in skin severity scores, trans-epidermal water loss (TEWL) and epidermal thickness compared to the control group at Week 6.	Water	117-122	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	22-25
32289425-1	2020	A homogeneous water-soluble flaky polysaccharide named LRP-1 (18.82 kDa) was extracted and purified from the rare edible and medicinal fungi Leccinum rugosiceps.	Water	14-19	LDL receptor related protein 1	Homo sapiens	55-60
32489012-2	2020	The sixteen resulting architectures are water-stable and optically pure, and exhibit improved antiproliferative selectivity against colon cancer cells (HCT116 p53 +/+ ) with respect to the non-cancerous ARPE-19 cell line.	Water	40-45	tumor protein p53	Homo sapiens	159-162
32907063-4	2020	Such a sea fog layer comprises spherical water particles of different radii, where the radii are divided into eight radius regions.	Water	41-46	zinc finger protein, FOG family member 1	Homo sapiens	11-14
32905448-3	2020	The probe SPI containing pyridinium salt group exhibited preeminent water solubility.	Water	68-73	chromogranin A	Homo sapiens	10-13
32922301-2	2020	TNF alpha reduces fluid absorption due to impairment of sodium and chloride transport required for building an osmotic gradient across epithelial cells, which in the airways maintains airway surface liquid helping to keep airways open and enabling bacterial clearance and aids water absorption from the alveolar spaces.	Water	277-282	tumor necrosis factor	Homo sapiens	0-9
32422455-9	2020	Geogenic materials (topsoil and mining tailings), and water samples could contain extremely high arsenic concentrations, i.e. 21,000 mg kg-1 or 1,700,000 mug L-1, respectively, have been found mainly at the "Iron Quadrangle".	Water	54-59	L1 cell adhesion molecule	Homo sapiens	158-161
32492591-2	2020	Climate changes could alter precipitation patterns and hydroperiods in woody wetlands, resulting in a hydrologic shift along the low elevation gradient and change the productions of DOC and DBP precursors and their exports to source water.	Water	233-238	D-box binding PAR bZIP transcription factor	Homo sapiens	190-193
32456908-0	2020	An HBT-based fluorescent dye with enhanced quantum yield in water system and its application for constructing NQO1 fluorescent probe.	Water	60-65	NAD(P)H quinone dehydrogenase 1	Homo sapiens	110-114
32790113-2	2020	Insulin treatment is associated with sodium and water retention, weight gain, and hypoglycaemia-all pathophysiological mechanisms related to HF decompensation.	Water	48-53	insulin	Homo sapiens	0-7
32600038-2	2020	OGWs contain high levels of chemical additives used to optimize extraction activities, such as surfactants, which have the potential to serve as organic DBP precursors in OGW-impacted water sources.	Water	184-189	D-box binding PAR bZIP transcription factor	Homo sapiens	153-156
32654485-3	2020	The crystal structure of alpha-CL-20/H2O and alpha-CL-20/N2O revealed by powder X-ray diffraction (PXRD) and the thermal stability order of alpha-CL-20/N2O, alpha-CL-20/CO2, alpha-CL-20/H2O and alpha-CL-20/H2O2 measured by differential scanning calorimeter (DSC) both show the excellent accordance between experiment results and simulative predication.	Water	37-40	epithelial membrane protein 1	Homo sapiens	31-36
32600038-8	2020	This finding is important to OGW-impacted source waters because drinking water plants with high-bromide source waters may switch to chloramination to meet DBP regulations.	Water	49-54	D-box binding PAR bZIP transcription factor	Homo sapiens	155-158
32337808-4	2020	By creating a deep electron trap state due to formation of an iodine dimer in presence of the lead vacancy interacting strongly with water molecules, the electron gets rapidly trapped on 4 ps and then recombines with the valence band free hole within sub-1 ns.	Water	133-138	SUB1 regulator of transcription	Homo sapiens	251-256
32759870-11	2020	In addition, with an extension, the model presented herein proved to be capable of describing the kinetics of the transformation of 1,5-diisocyanonaphthalene (1,5-DIN) into 1,5-diaminonaphthalene (1,5-DAN) in the mixtures of water/aprotic solvents.	Water	225-230	NBL1, DAN family BMP antagonist	Homo sapiens	201-204
32531136-7	2020	Moreover, limits of detection and limits of the quantification were in the range of 3-10 mug L-1 and 7-30 mug L-1 in water and biological samples, respectively.	Water	117-122	L1 cell adhesion molecule	Homo sapiens	93-96
32574112-3	2020	Of interest, our data indicate that despite their inability to taste sweetness, P2X2/3 DKO mice still prefer caloric sugars (including fructose and glucose) to water in long-term testing, although with diminished preference compared with control mice.	Water	160-165	purinergic receptor P2X, ligand-gated ion channel, 3	Mus musculus	80-86
32474952-8	2020	A positive correlation was noted between serum Gal-7 level and transepidermal water loss in patients with AD.	Water	78-83	galectin 7	Homo sapiens	47-52
32527531-0	2020	Facile synthesis of benzazoles through biocatalytic cyclization and dehydrogenation employing catalase in water.	Water	106-111	catalase	Homo sapiens	94-102
32527531-3	2020	Catalase is a metalloenzyme which is essential for the breakdown of toxic hydrogen peroxide into water and oxygen inside the cell.	Water	97-102	catalase	Homo sapiens	0-8
33149453-3	2020	Hence, the aim and objective of the study was to assess and compare the root caries remineralization effect of plain milk, 5ppm of fluoridated milk, and 5ppm of NaF in deionized water.	Water	178-183	C-X-C motif chemokine ligand 8	Homo sapiens	161-164
32540077-0	2020	Identification of acetylcholinesterase inhibitors in water by combining two-dimensional thin-layer chromatography and high-resolution mass spectrometry.	Water	53-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
32224384-5	2020	The total concentrations of the 11 target OPEs ( 11OPEs) in the water samples ranged 32.9-227 ng L-1.	Water	64-69	immunoglobulin kappa variable 1-16	Homo sapiens	97-100
32380020-2	2020	Sulfonylurea receptor 1 (SUR1) is an inducible protein that can form a heteromultimeric complex with aquaporin 4 (AQP4) that mediate the ion/water transport involved in brain tissue swelling.	Water	141-146	ATP binding cassette subfamily C member 8	Rattus norvegicus	0-23
32380020-2	2020	Sulfonylurea receptor 1 (SUR1) is an inducible protein that can form a heteromultimeric complex with aquaporin 4 (AQP4) that mediate the ion/water transport involved in brain tissue swelling.	Water	141-146	ATP binding cassette subfamily C member 8	Rattus norvegicus	25-29
32645216-8	2020	Additionally, the lyophilized water extract inhibited the in vitro activity of alpha-amylase, alpha-glucosidase, and angiotensin converting enzyme and showed cytotoxic effects towards Caco-2, A549, and HepG2 cancer cells, but no cytotoxicity towards IMR90 cells.	Water	30-35	angiotensin I converting enzyme	Homo sapiens	117-146
32942370-2	2020	In some cases the melting point of ice may be shifted and one may find either ice, icelike water, or a state in which freezing is completely inhibited.	Water	91-96	carboxylesterase 2	Homo sapiens	35-38
32312447-7	2020	The minimum detectable concentrations were far below the maximum concentration levels (60-200 mug L-1) set by the WHO for drinking water.	Water	131-136	L1 cell adhesion molecule	Homo sapiens	98-101
32333105-9	2020	The DSF- and SPI-based particleboard phantoms showed CT numbers close to those of water at the three X-ray CT energies.	Water	82-87	chromogranin A	Homo sapiens	13-16
32895167-7	2020	Treatment with the ERK inhibitor significantly lowered the permeability of blood-brain barrier and brain water content after brain trauma (P < 0.01).	Water	105-110	Eph receptor B1	Rattus norvegicus	19-22
32960801-6	2020	While the highest water and dye permeability were obtained with PES-PEG membrane, PSf-plain membrane gave the highest removal efficiency for Setazol Red and Setazol Blue dyes, which was found to be 78.33% and 82.52%, respectively, in the conditions of neutral pH and ambient temperature.	Water	18-23	insulin like growth factor binding protein 7	Homo sapiens	82-85
32167554-3	2020	In contrast, zebrafish lateral line hair cells, which detect water motion, require Tmc2a and Tmc2b.	Water	61-66	transmembrane channel-like 2b	Danio rerio	93-98
32725477-0	2021	Bipolar-current needle-knife with a water jet function (Jet B-knife) shortens the procedure time of endoscopic submucosal dissection for colorectal tumors.	Water	36-41	F-box and leucine rich repeat protein 15	Homo sapiens	42-45
32791746-1	2020	Vitamin B12 (B12), also known as cobalamin, is a water-soluble vitamin.	Water	49-54	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
32791746-1	2020	Vitamin B12 (B12), also known as cobalamin, is a water-soluble vitamin.	Water	49-54	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	13-16
32704066-1	2020	beta-Cyclodextrin (beta-CD) inclusion complex containing geranyl acetone as a guest was prepared by saturated water solution method.	Water	110-115	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	19-26
32731540-6	2020	Overall, the most active extracts in inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were ethanol/water and ethanol extracts from seeds (between 31.11 and 53.90%).	Water	135-140	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-73
32731540-6	2020	Overall, the most active extracts in inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were ethanol/water and ethanol extracts from seeds (between 31.11 and 53.90%).	Water	135-140	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79
32603085-6	2020	Such water flow characteristics ensure full contact between pharmaceutical pollutants and beta-CD grafted on the cellulose backbone of wood sawdust, thereby enhancing the water treatment efficiency.	Water	5-10	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	90-97
32603085-6	2020	Such water flow characteristics ensure full contact between pharmaceutical pollutants and beta-CD grafted on the cellulose backbone of wood sawdust, thereby enhancing the water treatment efficiency.	Water	171-176	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	90-97
32725477-0	2021	Bipolar-current needle-knife with a water jet function (Jet B-knife) shortens the procedure time of endoscopic submucosal dissection for colorectal tumors.	Water	36-41	F-box and leucine rich repeat protein 15	Homo sapiens	56-59
32725477-3	2021	In May 2012, a BB-knife combined with a water jet function (Jet B-knife) was newly developed.	Water	40-45	F-box and leucine rich repeat protein 15	Homo sapiens	46-49
32725477-3	2021	In May 2012, a BB-knife combined with a water jet function (Jet B-knife) was newly developed.	Water	40-45	F-box and leucine rich repeat protein 15	Homo sapiens	60-63
33013263-0	2020	Development of a novel in vitro assay to evaluate environmental water using an IL-8 reporter cell line.	Water	64-69	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
33013263-2	2020	Considering these characteristics, we examined the ability of the IL-8 luciferase assay using THP-G8 cells to evaluate water pollution.	Water	119-124	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
33013263-9	2020	These data suggest the potential of the IL-8 luciferase assay for evaluating environmental water pollution both quantitatively and qualitatively.	Water	91-96	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
32585093-1	2020	In this study, the binding to lysozyme (Lyz) of four important VIV compounds with antidiabetic and/or anticancer activity, [VIVO(pic)2(H2O)], [VIVO(ma)2], [VIVO(dhp)2], and [VIVO(acac)2], where pic-, ma-, dhp-, and acac- are picolinate, maltolate, 1,2-dimethyl-3-hydroxy-4(1H)-pyridinonate, and acetylacetonate anions, and of the vanadium-containing natural product amavadin ([VIV(hidpa)2]2-, with hidpa3- N-hydroxyimino-2,2"-diisopropionate) was investigated by ElectroSpray Ionization-Mass Spectrometry (ESI-MS).	Water	135-138	lysozyme	Homo sapiens	30-38
32708347-5	2020	Then, we activated tap water and examined the efficacy of PAW on wound healing in a mouse model of full-thickness skin wounds.	Water	23-28	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	19-22
32644786-7	2020	Transformation of U20Ppb10 in water over time to produce U24 was observed, possibly owing to its ability to incorporate K cations, which have been associated with the formation of U24.	Water	30-35	small nucleolar RNA, C/D box 24	Homo sapiens	57-60
32644786-7	2020	Transformation of U20Ppb10 in water over time to produce U24 was observed, possibly owing to its ability to incorporate K cations, which have been associated with the formation of U24.	Water	30-35	small nucleolar RNA, C/D box 24	Homo sapiens	180-183
32585093-1	2020	In this study, the binding to lysozyme (Lyz) of four important VIV compounds with antidiabetic and/or anticancer activity, [VIVO(pic)2(H2O)], [VIVO(ma)2], [VIVO(dhp)2], and [VIVO(acac)2], where pic-, ma-, dhp-, and acac- are picolinate, maltolate, 1,2-dimethyl-3-hydroxy-4(1H)-pyridinonate, and acetylacetonate anions, and of the vanadium-containing natural product amavadin ([VIV(hidpa)2]2-, with hidpa3- N-hydroxyimino-2,2"-diisopropionate) was investigated by ElectroSpray Ionization-Mass Spectrometry (ESI-MS).	Water	135-138	lysozyme	Homo sapiens	40-43
32585093-5	2020	The behavior of the systems with [VIVO(pic)2(H2O)] and Mb or Ub is very similar to that of Lyz.	Water	45-48	lysozyme	Homo sapiens	91-94
32698493-2	2020	This work is a key step towards the development of a full 6D pose SLAM framework adapted to karst aquifer, where potential water turbidity disqualifies vision-based methods, hence relying on acoustic sonar measurements.	Water	123-128	signaling lymphocytic activation molecule family member 1	Homo sapiens	66-70
32707664-2	2020	METHODS: Uptake of two water-soluble functionalized C70 fullerenes with different types of aromatic addends (ethylphenylmalonate and thienylacetate) in human fetal lung fibroblasts, intracellular ROS visualization, superoxide scavenging potential, NOX4 expression, NRF2 expression, oxidative DNA damage, repair genes, cell proliferation and cell cycle were studied.	Water	23-28	NFE2 like bZIP transcription factor 2	Homo sapiens	265-269
32765630-8	2020	Results: The acetylcholinesterase inhibitory activity from Q. suber cork and corkback ethanol-water extracts was as follows: 62% inhibition with corkback extracts over 0.5 mg/mL and around 49% inhibition in cork extracts over 1.0 mg/mL extracts" concentration.	Water	94-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	13-33
32832640-3	2020	The second mimicked functionality is that of catalase by incorporation of Pt nanoparticles, which catalyze hydrogen peroxide disproportionation to water and oxygen.	Water	147-152	catalase	Homo sapiens	45-53
31712142-6	2020	Importantly, our further results in vitro suggested that Myr remarkably attenuated H2O2-triggered hepatotoxicity and ROS generation, activated Keap1-Nrf2/HO-1 and AMPK/ACC signaling pathway.	Water	83-87	nuclear factor, erythroid derived 2, like 2	Mus musculus	149-153
32551690-4	2020	NO3- induces the ultrafast (static) scavenging of photoexcited electronic states of liquid water and the dynamic scavenging of detached electrons with a reaction rate that is dependent on the excitation energy.	Water	91-96	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
32574493-4	2020	In this study, we find striking resemblance between the vibrational properties of three water molecules connected via strong hydrogen bonds in the trihydrate of LiNO3 and those of ordinary ice Ih.	Water	88-93	carboxylesterase 2	Homo sapiens	189-192
32574493-5	2020	As in ice, the vibrations of the hydrate water molecules show ultrafast excited state dynamics that are strongly accelerated when proceeding from deuterated to neat H2O samples.	Water	41-46	carboxylesterase 2	Homo sapiens	6-9
32574493-5	2020	As in ice, the vibrations of the hydrate water molecules show ultrafast excited state dynamics that are strongly accelerated when proceeding from deuterated to neat H2O samples.	Water	165-168	carboxylesterase 2	Homo sapiens	6-9
32361496-0	2020	Efficient removal of triclosan via peroxymonosulfate activated by a ppb level dosage of Co(II) in water: Reaction kinetics, mechanisms and detoxification.	Water	98-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
32194107-0	2020	Physically cross-linked aerogels based on germinated and non-germinated wheat starch and PEO for application as water absorbers for food packaging.	Water	112-117	twinkle mtDNA helicase	Homo sapiens	89-92
32194107-8	2020	However, addition of PEO increased the water absorption capacity and reduced the hardness and cohesion of the resulting aerogels.	Water	39-44	twinkle mtDNA helicase	Homo sapiens	21-24
31712142-6	2020	Importantly, our further results in vitro suggested that Myr remarkably attenuated H2O2-triggered hepatotoxicity and ROS generation, activated Keap1-Nrf2/HO-1 and AMPK/ACC signaling pathway.	Water	83-87	heme oxygenase 1	Mus musculus	154-158
32224171-2	2020	Immobilization of beta-cyclodextrin (beta-CD) to zein was achieved by the Maillard reaction and the zein-graft-beta-CD powders showed higher glass transition temperature and higher solubility in water.	Water	195-200	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	37-44
32224171-2	2020	Immobilization of beta-cyclodextrin (beta-CD) to zein was achieved by the Maillard reaction and the zein-graft-beta-CD powders showed higher glass transition temperature and higher solubility in water.	Water	195-200	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	111-118
31712142-8	2020	Meanwhile, Myr-relieved hepatotoxicity excited by H2O2 was blocked by Nrf2-null and AMPK inhibitor.	Water	50-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	70-74
32320873-6	2020	Direct wash-off of animal waste from dairy farms results in higher NO3- concentrations in surface water than in groundwater.	Water	98-103	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
32310123-8	2020	Functional predictions indicate that the function of ABC transporter was highest in the hospital sewage water samples (YYW), while two-component system was more abundant in the XXW samples.	Water	104-109	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	53-68
32668925-1	2020	We study the prototypical SN2 reaction Cl- + CH3Cl   CH3Cl + Cl- in water using quantum mechanics/molecular mechanics (QM/MM) computer simulations with transition path sampling and inertial likelihood maximization.	Water	68-73	solute carrier family 38 member 5	Homo sapiens	26-29
32608896-5	2020	The results showed that the bottom water of the lower terrain rapidly entered the anaerobic condition after the system was deactivated, resulting in the release of a large amount of dissolved manganese into the overlying water, the maximum concentration of which was 0.42 mg L-1.	Water	35-40	L1 cell adhesion molecule	Homo sapiens	275-278
32648941-6	2021	A water-soluble form of Lynx1, ws-Lynx1, was expressed in E. coli, its 1 H-NMR structure and binding to several nAChRs determined.	Water	2-7	Ly6/neurotoxin 1	Homo sapiens	24-29
32648941-6	2021	A water-soluble form of Lynx1, ws-Lynx1, was expressed in E. coli, its 1 H-NMR structure and binding to several nAChRs determined.	Water	2-7	Ly6/neurotoxin 1	Homo sapiens	34-39
32659957-1	2020	The present work introduces both synthesis of silica nanoparticles doped with CoII ions by means of differently modified microemulsion water-in-oil (w/o) and Stober techniques and characterization of the hybrid nanoparticles (CoII@SiO2) by TEM, DLS, XRD, ICP-EOS, SAXS, UV-Vis, and UV-Vis/DR spectroscopy and electrochemical methods.	Water	135-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
32199204-3	2020	The results showed that the presence of 2-50 g L-1 microplastics could decrease the pesticide residues in water.	Water	106-111	immunoglobulin kappa variable 1-16	Homo sapiens	47-50
32684872-0	2020	Tritiated Water Induces Toxicity in Human Umbilical Vein Vascular Endothelial Cells via IL8.	Water	10-15	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
32650545-0	2020	Potential Metabolite Nymphayol Isolated from Water Lily (Nymphaea stellata) Flower Inhibits MCF-7 Human Breast Cancer Cell Growth via Upregulation of Cdkn2a, pRb2, p53 and Downregulation of PCNA mRNA Expressions.	Water	45-50	cyclin dependent kinase inhibitor 2A	Homo sapiens	150-156
32650545-0	2020	Potential Metabolite Nymphayol Isolated from Water Lily (Nymphaea stellata) Flower Inhibits MCF-7 Human Breast Cancer Cell Growth via Upregulation of Cdkn2a, pRb2, p53 and Downregulation of PCNA mRNA Expressions.	Water	45-50	tumor protein p53	Homo sapiens	164-167
32460500-3	2020	Our results demonstrated that the PA membrane surface"s roughness is a key factor of surface"s bio-fouling, as the lysozyme protein adsorbed on the surface"s cavity site displays extremely low surface diffusivity, blocking water passage and decreasing water flux.	Water	223-228	lysozyme	Homo sapiens	115-123
32460500-3	2020	Our results demonstrated that the PA membrane surface"s roughness is a key factor of surface"s bio-fouling, as the lysozyme protein adsorbed on the surface"s cavity site displays extremely low surface diffusivity, blocking water passage and decreasing water flux.	Water	252-257	lysozyme	Homo sapiens	115-123
32623574-5	2020	The highest concentration levels in the samples taken from both types of water were 0.9 and 60 mug L-1 for BPA and DEHP, respectively.	Water	73-78	L1 cell adhesion molecule	Homo sapiens	99-102
32486643-2	2020	Here, wholly visible-light responsive supramolecular gel was fabricated through the host-guest interaction between beta-cyclodextrin (beta-CD) dimer and tetra-ortho-methoxy-substituted azobenzene (mAzo) dimer (binary gelator) in DMSO/H2O (V/V = 8/2).	Water	234-237	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	134-141
32510942-1	2020	Reaction of the metalloligand IrIII(ppy-COOH)3 and the anisotropic paramagnetic CoII ion under solvothermal conditions resulted in a metal-metalloligand coordination polymer, [CoII3(mu3-O)(mu-OH2){IrIII(ppy-COO)2(ppy-COOH)}2(H2O)4] 2DMF xH2O (I).	Water	225-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-84
32628666-4	2020	This study investigated how snail host abundance and release of cercariae (the free swimming stage infective to humans) varies at water access sites in an endemic region in Senegal, a setting where human schistosomiasis prevalence is among the highest globally.	Water	130-135	snail family transcriptional repressor 1	Homo sapiens	28-33
32143162-0	2020	Amine functionalized egg albumin hydrogel with enhanced adsorption potential for diclofenac sodium in water.	Water	102-107	albumin	Homo sapiens	25-32
32126427-6	2020	Finally, application to fortified real water demonstrated that in situ magnetic hydrochar produced by suggested approach was successful at adsorptive removal of Pb(II) from water with no matrix effects.	Water	39-44	submaxillary gland androgen regulated protein 3B	Homo sapiens	161-167
32126427-6	2020	Finally, application to fortified real water demonstrated that in situ magnetic hydrochar produced by suggested approach was successful at adsorptive removal of Pb(II) from water with no matrix effects.	Water	173-178	submaxillary gland androgen regulated protein 3B	Homo sapiens	161-167
32143160-2	2020	In this study, carboxymethyl beta-cyclodextrin (CM-beta-CD), as an alternative to gold nanoparticle, was used to modified titanium dioxide (CM-beta-CD-P25) to accelerate photoelectron transmission and enhance the organic contaminants removal from water.	Water	247-252	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	51-58
32143160-2	2020	In this study, carboxymethyl beta-cyclodextrin (CM-beta-CD), as an alternative to gold nanoparticle, was used to modified titanium dioxide (CM-beta-CD-P25) to accelerate photoelectron transmission and enhance the organic contaminants removal from water.	Water	247-252	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	143-150
32573587-9	2020	The Morris water maze experiment showed that scopolamine-induced AD-like dementia in rats treated with PC/SHP-2-Bn/SHP-2-16 nanoparticles was significantly reduced.	Water	11-16	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	106-111
32424866-7	2020	RESULTS: In this study, Munc13-1 C1 shows higher conformational stability in ethanol than in water.	Water	93-98	unc-13 homolog A	Homo sapiens	24-32
32201307-3	2020	Complex III catalyzes oxidation of quinol and reduction of water-soluble cytochrome c (cyt c), while complex IV catalyzes oxidation of the reduced cyt c and reduction of dioxygen to water.	Water	59-64	cytochrome c, somatic	Homo sapiens	73-85
32201307-3	2020	Complex III catalyzes oxidation of quinol and reduction of water-soluble cytochrome c (cyt c), while complex IV catalyzes oxidation of the reduced cyt c and reduction of dioxygen to water.	Water	59-64	cytochrome c, somatic	Homo sapiens	87-92
32201307-3	2020	Complex III catalyzes oxidation of quinol and reduction of water-soluble cytochrome c (cyt c), while complex IV catalyzes oxidation of the reduced cyt c and reduction of dioxygen to water.	Water	182-187	cytochrome c, somatic	Homo sapiens	87-92
32201307-3	2020	Complex III catalyzes oxidation of quinol and reduction of water-soluble cytochrome c (cyt c), while complex IV catalyzes oxidation of the reduced cyt c and reduction of dioxygen to water.	Water	182-187	cytochrome c, somatic	Homo sapiens	147-152
32201307-6	2020	To answer these questions, we use a theoretical approach and assume that cyt c diffuses in the water phase while complexes III and IV either diffuse independently in the two dimensions of the membrane or form supercomplexes.	Water	95-100	cytochrome c, somatic	Homo sapiens	73-78
32437693-13	2020	Compared to the RT + Water treated animals ("reference group"), combination of WT eating and alcohol consumption (WT + Alcohol) significantly changed the per2 oscillatory pattern, that was different between the colon and hypothalamus, indicative of worsening circadian dyssynchrony.	Water	21-26	period circadian clock 2	Mus musculus	154-158
32443213-4	2020	For alkylphenols concentrations ranged from 1.1 to 78.3 ng L-1 in wastewater and from 0.1 to 37.2 ng L-1 in surface water, while in drinking water concentrations varied from 0.4 to 7.9 ng L-1.	Water	71-76	L1 cell adhesion molecule	Homo sapiens	59-62
32278281-0	2020	Synthesis of water soluble CuGaS2/ZnS quantum dots for ultrasensitive fluorescent detection of alkaline phosphatase based on inner filter effect.	Water	13-18	alkaline phosphatase, placental	Homo sapiens	95-115
32126334-3	2020	And the obtained epsilon-MnO2 nanoflowers were employed to remove Pb(II) from water.	Water	78-83	submaxillary gland androgen regulated protein 3B	Homo sapiens	66-72
32242612-6	2020	We found that in ice-water swimmers, PTH and TSH increased and free T3, T4 decreased after 15min winter swim while NST inducing cold exposure failed to regulate PTH and free T4 and lowered TSH and free T3.	Water	21-26	parathyroid hormone	Homo sapiens	37-40
32242612-7	2020	Ice-water swimming-induced increase in PTH correlated negatively with systemic calcium and positively with phosphorus.	Water	4-9	parathyroid hormone	Homo sapiens	39-42
32443213-4	2020	For alkylphenols concentrations ranged from 1.1 to 78.3 ng L-1 in wastewater and from 0.1 to 37.2 ng L-1 in surface water, while in drinking water concentrations varied from 0.4 to 7.9 ng L-1.	Water	116-121	L1 cell adhesion molecule	Homo sapiens	101-104
32728594-4	2020	Our results show that population under water stress is expected to increase by 50% under a low population growth and emissions scenario (SSP1-RCP2.6) and double under a high population growth and emission scenario (SSP3-RCP6.0), compared to the year 2010.	Water	39-44	SUMO specific peptidase 6	Homo sapiens	137-141
32443213-4	2020	For alkylphenols concentrations ranged from 1.1 to 78.3 ng L-1 in wastewater and from 0.1 to 37.2 ng L-1 in surface water, while in drinking water concentrations varied from 0.4 to 7.9 ng L-1.	Water	116-121	L1 cell adhesion molecule	Homo sapiens	101-104
30628559-4	2020	The MF of the water previously adsorbed in the GAC fixed bed allowed the greater removal of 100% of the carbamates pesticides with an initial concentration of 25 mug L-1 during the first 48 h of operation.	Water	14-19	immunoglobulin kappa variable 1-16	Homo sapiens	166-169
32443213-9	2020	In drinking water, EEQt was below 1 ng L-1 in all samples.	Water	12-17	L1 cell adhesion molecule	Homo sapiens	39-42
31524089-12	2020	Regardless of body composition changes, athletes who increase reactance and resistance reduced extracellular water and body fluids while those who raised PhA increased intracellular water.	Water	182-187	lamin B receptor	Homo sapiens	154-157
32753784-0	2020	Attenuation of core temperature elevation and interleukin-6 excretion during head-out hot water immersion in elderly people.	Water	90-95	interleukin 6	Homo sapiens	46-59
32466946-0	2020	Catalase to demulsify oil-in-water fish oil-polysorbate emulsion and affect lipid oxidation.	Water	29-34	catalase	Homo sapiens	0-8
32549616-0	2020	Mungbean seed coat water extract inhibits inflammation in LPS-induced acute liver injury mice and LPS-stimulated RAW 246.7 macrophages via the inhibition of TAK1/IkappaBalpha/NF-kappaB.	Water	19-24	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	162-174
32549616-0	2020	Mungbean seed coat water extract inhibits inflammation in LPS-induced acute liver injury mice and LPS-stimulated RAW 246.7 macrophages via the inhibition of TAK1/IkappaBalpha/NF-kappaB.	Water	19-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	175-184
32379622-7	2020	Furthermore, CSDS treatment did not alter the plasma levels of interleukin-6 (IL-6) of betaine-treated mice whereas CSDS caused higher plasma levels of IL-6 in water-treated mice.	Water	160-165	interleukin 6	Mus musculus	152-156
32325220-7	2020	However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine).	Water	308-313	dipeptidase 3	Homo sapiens	9-14
32753784-2	2020	Recent studies have reported that 20 minutes of head-out immersion in hot water (42 C) increased serum interleukin-6 levels in young males.	Water	74-79	interleukin 6	Homo sapiens	103-116
32753784-3	2020	This study aimed to compare the efficacy of head-out immersion in hot water (42 C) on serum interleukin-6 levels in seven elderly (66-75 years old) and eight young males (21-32 years old).	Water	70-75	interleukin 6	Homo sapiens	92-105
32753784-7	2020	Serum interleukin-6 levels were significantly higher in young participants 1 hour after the head-out immersion in hot water (42 C); however, serum interleukin-6 levels did not change in elderly participants.	Water	118-123	interleukin 6	Homo sapiens	6-19
32753784-9	2020	[Conclusion] The current study demonstrated that head-out immersion in hot water (42 C) more attenuated core temperature and interleukin-6 levels in elderly participants than in young participants.	Water	75-80	interleukin 6	Homo sapiens	125-138
32434851-1	2020	Aquaporin-1 (AQP1) dual water and ion channels enhance migration and invasion when upregulated in leading edges of certain classes of cancer cells.	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
32229502-2	2020	Aquaporin-9 (AQP9) is a transmembrane protein that transports water and reportedly transports H2O2.	Water	62-67	aquaporin 9	Homo sapiens	0-11
32229502-2	2020	Aquaporin-9 (AQP9) is a transmembrane protein that transports water and reportedly transports H2O2.	Water	62-67	aquaporin 9	Homo sapiens	13-17
33016495-8	2020	Generally, current findings confirm that (NH4 )2 SO4 treatments have lowered the pH, enhanced levels of exchangeable Al3+ , and increased stream-water exports of NO3 - and base cations-a process that further acidifies soil.	Water	145-150	NBL1, DAN family BMP antagonist	Homo sapiens	162-165
32903920-1	2020	Loss of function of arginine vasopressin receptor 2 (AVPR2) may affect the recognition and binding of arginine vasopressin (AVP) which, in turn, may prevent the activation of Gs/adenylate cyclase and reduce the reabsorption of water by renal tubules and combined tubes.	Water	227-232	arginine vasopressin receptor 2	Homo sapiens	20-51
32903920-1	2020	Loss of function of arginine vasopressin receptor 2 (AVPR2) may affect the recognition and binding of arginine vasopressin (AVP) which, in turn, may prevent the activation of Gs/adenylate cyclase and reduce the reabsorption of water by renal tubules and combined tubes.	Water	227-232	arginine vasopressin receptor 2	Homo sapiens	53-58
32434851-1	2020	Aquaporin-1 (AQP1) dual water and ion channels enhance migration and invasion when upregulated in leading edges of certain classes of cancer cells.	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
32247143-1	2020	It is crucial to quantitatively track riverine nitrate (NO3-) sources and transformations in drinking water source watersheds for preventing current and future NO3- pollution, and ensuring a safe drinking water supply.	Water	102-107	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
31838004-8	2020	Peroxiredoxin 2 and catalase, in particular, played an important role in endogenous and exogenous H2O2 degradation, respectively.	Water	98-102	peroxiredoxin 2	Homo sapiens	0-15
31838004-8	2020	Peroxiredoxin 2 and catalase, in particular, played an important role in endogenous and exogenous H2O2 degradation, respectively.	Water	98-102	catalase	Homo sapiens	20-28
32583581-6	2020	Remarkably, nitrate conversion and nitrogen selectivity are both close to 100% in an ultralow concentration of 10 mg L-1 , meeting drinking water standard.	Water	140-145	L1 cell adhesion molecule	Homo sapiens	117-120
32247143-1	2020	It is crucial to quantitatively track riverine nitrate (NO3-) sources and transformations in drinking water source watersheds for preventing current and future NO3- pollution, and ensuring a safe drinking water supply.	Water	102-107	NBL1, DAN family BMP antagonist	Homo sapiens	160-163
32247143-9	2020	This work provides a comprehensive approach to distinguish riverine NO3- sources in drinking water source watersheds, which helps guide implementation of management strategies to effectively control NO3- contamination and protect drinking water quality.	Water	93-98	NBL1, DAN family BMP antagonist	Homo sapiens	68-71
32247143-9	2020	This work provides a comprehensive approach to distinguish riverine NO3- sources in drinking water source watersheds, which helps guide implementation of management strategies to effectively control NO3- contamination and protect drinking water quality.	Water	106-111	NBL1, DAN family BMP antagonist	Homo sapiens	68-71
32247143-9	2020	This work provides a comprehensive approach to distinguish riverine NO3- sources in drinking water source watersheds, which helps guide implementation of management strategies to effectively control NO3- contamination and protect drinking water quality.	Water	106-111	NBL1, DAN family BMP antagonist	Homo sapiens	199-202
32581267-1	2020	The physiological role of the renal ClC-Ka/ClC-K1 channels is to confer a high Cl- permeability to the thin Ascending Limb of Henle (tAL), which in turn is essential for establishing the high osmolarity of the renal medulla that drives water reabsorption from collecting ducts.	Water	236-241	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	133-136
32629864-4	2020	Here we report the in vitro delivery of a water-soluble cationic PDT drug, zinc phthalocyanine choline derivative (Cholosens), by biodegradable microcapsules assembled from dextran sulfate (DS) and poly-l-arginine (PArg).	Water	42-47	poly(ADP-ribose) glycohydrolase	Homo sapiens	215-219
32601774-2	2020	The emphasis was to look for spatial and temporal variation in the sedimentation rate along the continental shelf of eastern Arabian Sea between Goa to Kochi for water depth <= 150 m. This study showed varying sedimentation rates in coastal and distant sediment cores.	Water	162-167	tripartite motif containing 47	Homo sapiens	145-148
32601932-0	2020	Major and trace elements in the surface water of Tonle Sap Lake, Mekong River, and other tributary rivers in Cambodia.	Water	40-45	SH2 domain containing 1A	Homo sapiens	55-58
32601932-3	2020	During the rainy season, the elemental composition of lake water (B1) appeared to be greatly influenced by the intrusion of water from the Mekong River (B1) through the Tonle Sap River (B1).	Water	59-64	SH2 domain containing 1A	Homo sapiens	175-178
32476403-2	2020	Especially, nanofibrils can increase the specific area of the hump to capture fog droplets effectively and transport water in channels between the nanofibrils under humid conditions, and thus the fog droplets can coalesce and be highly efficiently transported toward humps for water collection directionally.	Water	117-122	zinc finger protein, FOG family member 1	Homo sapiens	78-81
32476403-2	2020	Especially, nanofibrils can increase the specific area of the hump to capture fog droplets effectively and transport water in channels between the nanofibrils under humid conditions, and thus the fog droplets can coalesce and be highly efficiently transported toward humps for water collection directionally.	Water	117-122	zinc finger protein, FOG family member 1	Homo sapiens	196-199
32476403-2	2020	Especially, nanofibrils can increase the specific area of the hump to capture fog droplets effectively and transport water in channels between the nanofibrils under humid conditions, and thus the fog droplets can coalesce and be highly efficiently transported toward humps for water collection directionally.	Water	277-282	zinc finger protein, FOG family member 1	Homo sapiens	78-81
32476403-2	2020	Especially, nanofibrils can increase the specific area of the hump to capture fog droplets effectively and transport water in channels between the nanofibrils under humid conditions, and thus the fog droplets can coalesce and be highly efficiently transported toward humps for water collection directionally.	Water	277-282	zinc finger protein, FOG family member 1	Homo sapiens	196-199
32848308-1	2020	Aim: This study aimed to investigate the association of single nucleotide polymorphism of the myostatin (MSTN) and fatty acid-binding protein 4 (FABP4) genes on the total water, ash, fat, protein, and cholesterol contents of sirloin (gluteus medius muscle) and silverside (biceps femoris muscle) meats of cull female Aceh cattle.	Water	171-176	fatty acid-binding protein, adipocyte	Bos taurus	145-150
32610643-8	2020	Everolimus is an mTOR inhibitor that induces autophagy, but with higher water solubility.	Water	72-77	mechanistic target of rapamycin kinase	Homo sapiens	17-21
32213406-5	2020	To improve nitrogen removal performance and reduce N2O emission, the optimal gas-water ratios for BAF1 and BAF2 were 5:1 and 1.5:1, respectively.	Water	81-86	BANF family member 2	Homo sapiens	107-111
32576929-1	2020	Aquaporins (AQP) are not only water channel protein, but also potential prognostic indicator and therapeutic target for rectal cancer.	Water	30-35	aquaporin 1 (Colton blood group)	Homo sapiens	12-15
32429666-0	2020	Optimal design of fog collector: Water unidirectional transport on a system integrated by conical copper needles with gradient wettability and hydrophilic slippery rough surfaces.	Water	33-38	zinc finger protein, FOG family member 1	Homo sapiens	18-21
32429666-4	2020	It is demonstrated that a newly enhanced fog harvesting mechanism and higher fog collection rate can be realized due to the synergy between the Laplace pressure difference from conical needle, wettability force of wettability difference in the conical copper needles and the released surface energy in droplet coalescence, in addition to the attracting force from water bridge formed between needles and substrate.	Water	364-369	zinc finger protein, FOG family member 1	Homo sapiens	41-44
32429666-4	2020	It is demonstrated that a newly enhanced fog harvesting mechanism and higher fog collection rate can be realized due to the synergy between the Laplace pressure difference from conical needle, wettability force of wettability difference in the conical copper needles and the released surface energy in droplet coalescence, in addition to the attracting force from water bridge formed between needles and substrate.	Water	364-369	zinc finger protein, FOG family member 1	Homo sapiens	77-80
32429666-6	2020	This fog collector provides a direction to design of water harvesting system, which has important promotion significance for water collection application engineering in industry, aerospace and other fields.	Water	53-58	zinc finger protein, FOG family member 1	Homo sapiens	5-8
32429666-6	2020	This fog collector provides a direction to design of water harvesting system, which has important promotion significance for water collection application engineering in industry, aerospace and other fields.	Water	125-130	zinc finger protein, FOG family member 1	Homo sapiens	5-8
32570894-3	2020	On water, PPh3 was effective as a ligand along with a lower charge of the catalyst Pd(OAc)2 (5 mol%) at 100  C, leading to C3-aryled 1H-indazoles or C3-aryled 1H-7-azaindazoles in moderate to good yields.	Water	3-8	caveolin 1	Homo sapiens	10-14
32189464-2	2020	A neutral cobalt(II) complex, [Co II (COO-terpy) 2 ] 4H 2 O ( 1 4H 2 O ), stably formed cavities generated via pi-pi stacking motifs and hydrogen bond networks, resulted in the accommodation of four water molecules.	Water	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
32441526-8	2020	A thick blanket of C60 on top of pure amorphous ice is found to display large cracks due to water desorption.	Water	92-97	carboxylesterase 2	Homo sapiens	48-51
32432582-6	2020	Interestingly, the PEG-LZM-polyphenol hydrogel has a higher water content than other polyphenol-toughened hydrogels, which may better meet the clinical needs for hydrogel materials.	Water	60-65	lysozyme	Homo sapiens	23-26
32612510-13	2020	The different types of pituitary prolactin in fish play particularly important roles in the adaptation of eutherian species to fresh water environments.	Water	133-138	prolactin	Homo sapiens	33-42
32560242-2	2020	Aquaporin-2 (AQP2), a vasopressin-regulated water channel protein, is known to be selectively excreted into the urine through exosomes (UE-AQP2), and its renal expression is decreased in nephrotic syndrome.	Water	44-49	arginine vasopressin	Rattus norvegicus	22-33
32612510-15	2020	In turn, the released prolactin acts on branchial epithelia, especially ionocytes of the gill to retain salt and excrete water.	Water	121-126	prolactin	Homo sapiens	22-31
32579133-4	2020	We combined intratumoral administration of the synthetic toll-like receptor 4 agonist glucopyranosyl lipid A (oil-in-water formulation, G100) with either active vaccination or adoptive transfer of tumor-specific CD8 T cells to mice bearing established melanomas or orthotopically inoculated glioblastomas.	Water	117-122	toll-like receptor 4	Mus musculus	57-77
32110844-9	2020	CONCLUSION: It was demonstrated that the inexpensive and easy handling adapted acetone method was applicable in delta15 N-NO3 - analysis for saline water samples when the sample aliquot contained about 4 mumol of NO3 - with less than 6 g of Cl- .	Water	148-153	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
32325245-1	2020	We report the synthesis of water soluble cyclodextrin (CD) polymers prepared by crosslinking pyromellitic dianhydride (PMDA) with two CD derivatives (methyl-beta-CD - MbetaCD and (2-hydroxy)propyl-beta-CD - HPbetaCD) and their evaluation as functional sub-micron sized carriers in the development of antiretroviral drug delivery systems.	Water	27-32	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	157-164
32325245-1	2020	We report the synthesis of water soluble cyclodextrin (CD) polymers prepared by crosslinking pyromellitic dianhydride (PMDA) with two CD derivatives (methyl-beta-CD - MbetaCD and (2-hydroxy)propyl-beta-CD - HPbetaCD) and their evaluation as functional sub-micron sized carriers in the development of antiretroviral drug delivery systems.	Water	27-32	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	197-204
32655658-0	2020	Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats.	Water	29-34	Eph receptor B1	Rattus norvegicus	97-100
32110844-9	2020	CONCLUSION: It was demonstrated that the inexpensive and easy handling adapted acetone method was applicable in delta15 N-NO3 - analysis for saline water samples when the sample aliquot contained about 4 mumol of NO3 - with less than 6 g of Cl- .	Water	148-153	NBL1, DAN family BMP antagonist	Homo sapiens	213-216
32527100-4	2020	SA adsorption was governed by ionic repulsive forces and hydrophobic interactions as evidenced from an increase in the protein adsorption at lower pH (6.5 compared to 7.4) and a correlation with surface coverage when water (pH 6.5) was used as the medium.	Water	217-222	albumin	Homo sapiens	0-2
32596586-1	2020	Thiosemicarbazide-modified cellulose (MTC) has been studied for removing heavy metals in the water source or for extracting some precious metals.	Water	93-98	metallothionein 1A	Homo sapiens	38-41
32425044-8	2020	Non-IBS of the hyperactive AFP expose towards the bulk and able to maintain the liquid-like character of its hydration water up to 15 A.	Water	119-124	alpha fetoprotein	Homo sapiens	27-30
32469012-0	2020	Detection of electric-quadrupole transitions in water vapour near 5.4 and 2.5 mum.	Water	48-53	latexin	Homo sapiens	78-81
32401517-6	2020	Water confined between surfaces consisting of alternating hydrophilic and hydrophobic regions exhibit a strong-to-strong dynamical transition in the diffusion coefficients and rotational relaxation times at a crossover temperature of 237 K and show a fragile-to-strong transition in the alpha-relaxation time at 238 K. The observed crossover temperature is much higher than the freezing point of the SPC/E water model used in this study, indicating that these dynamical transitions can occur with mild supercooling under strong confinement in the absence of bulk-like water.	Water	0-5	surfactant protein C	Homo sapiens	400-403
32596569-11	2020	(4) The pore throats of the target reservoir mainly range from 0.001 to 10 mum, and the bound water mainly distributes in pores less than 0.2 mum.	Water	94-99	latexin	Homo sapiens	142-145
32383881-5	2020	Molecular modeling and structure-activity relationships support binding to HDAC1 with tetrahydropyran acting as a hydrophobic shield from water at the enzyme surface.	Water	138-143	histone deacetylase 1	Homo sapiens	75-80
32396322-3	2020	To investigate the role played by the dopant, the degradation of Rhodamine-beta (Rh-beta), a dye pollutant widely present in natural water sources, is studied when the catalyst is irradiated by ultraviolet (UV) light or ultrasound (US) waves.	Water	133-138	DExH-box helicase 9	Homo sapiens	65-88
32412242-4	2020	Specifically, we found that an aryl-bromide bond activation can be achieved with blue photons, and we obtained full conversion for the very energy-demanding decomposition of a persistent ammonium compound as typical water pollutant, not only with a cw laser but also with an LED light source.	Water	216-221	small integral membrane protein 10 like 2A	Homo sapiens	275-278
32469012-2	2020	Very recently, electric-quadrupole transitions have been detected in the high sensitivity cavity ring down spectrum (CRDS) of water vapour near 1.3 mum [A. Campargue et al., Phys.	Water	126-131	latexin	Homo sapiens	148-151
32384233-5	2020	A test calculation based on the MTD-SHS simulation of met-enkephalin in explicit water with 7 CVs was conducted.	Water	81-86	proopiomelanocortin	Homo sapiens	54-68
32237204-1	2020	We present an experimental in-situ study to investigate the effects of catalyst layer (CL) and cathode microporous layer (MPL C ) perforation on the water management and performance of polymer electrolyte membrane fuel cells (PEMFCs).	Water	149-154	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	122-125
32412571-1	2020	In this report, the synthesis, characterization and electrocatalytic oxidation of water by a mononuclear cobalt(iii) complex, [CoIII(dpaq)(Cl)]Cl (1) featuring a redox-active pentadentate amidate ligand (H-dpaq = 2-[bis(pyridin-2-ylmethyl)]amino-N-quinolin-8-yl-acetamidate) is reported.	Water	82-87	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	127-132
32517273-2	2020	By soaking crystals of 1 in a mixture of DMF-H2O solution containing a slight excess of Cu(NO3)2 x 3H2O a transmetalation reaction occurred affording the related copper(II) complex trans-[CuL2(H2O)2] (2).	Water	45-48	cullin 2	Homo sapiens	188-192
28722952-0	2022	Vitamin, B12 (Cobalamin), Deficiency Vitamin B12 (Cobalamin) is a water-soluble vitamin that is derived from animal products such as red meat, dairy, and eggs.	Water	66-71	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	9-12
28722952-0	2022	Vitamin, B12 (Cobalamin), Deficiency Vitamin B12 (Cobalamin) is a water-soluble vitamin that is derived from animal products such as red meat, dairy, and eggs.	Water	66-71	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	45-48
32517273-2	2020	By soaking crystals of 1 in a mixture of DMF-H2O solution containing a slight excess of Cu(NO3)2 x 3H2O a transmetalation reaction occurred affording the related copper(II) complex trans-[CuL2(H2O)2] (2).	Water	100-103	cullin 2	Homo sapiens	188-192
32503967-5	2020	Fog and cloud readily form under winter haze conditions, leading to high liquid water contents with high pH (>5.5) from elevated ammonia.	Water	80-85	zinc finger protein, FOG family member 1	Homo sapiens	0-3
32045803-3	2020	By rationally controlling synthetic parameters, we find that optimum Cu0.3@Cu0.7CoOx@GO achieves a superior catalytic activity with a turnover frequency of 44.6 molH2 molM-1 min-1 in H2O and 98.2 molH2 molM-1 min-1 in 0.2 M NaOH, better than most of previously reported NM-free nanocatalysts.	Water	183-186	CD59 molecule (CD59 blood group)	Homo sapiens	174-179
32045803-3	2020	By rationally controlling synthetic parameters, we find that optimum Cu0.3@Cu0.7CoOx@GO achieves a superior catalytic activity with a turnover frequency of 44.6 molH2 molM-1 min-1 in H2O and 98.2 molH2 molM-1 min-1 in 0.2 M NaOH, better than most of previously reported NM-free nanocatalysts.	Water	183-186	CD59 molecule (CD59 blood group)	Homo sapiens	209-214
32420829-1	2021	The results of experimental study on effectiveness of gas phase total oxidation of toluene towards carbon dioxide and water with the aid of ozone over Co(II)/ SiO2 catalyst are presented in this work.	Water	118-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
32392065-0	2020	Effects of Inorganic Ions on Ice Nucleation by the Al-Surface of Kaolinite Immersed in Water.	Water	87-92	caspase 1	Homo sapiens	29-32
32392065-9	2020	In all cases, the supercooling required for ice nucleation was larger by 1 - 6 K, after accounting for freezing point depression, than that required for pure water.	Water	158-163	caspase 1	Homo sapiens	44-47
32392065-10	2020	For 1 M LiI solution an earlier laboratory study using kaolin as ice nucleating particles (INP) reported that the supercooling required for ice nucleation was 11 K smaller than that required for pure water.	Water	200-205	caspase 1	Homo sapiens	140-143
32392065-13	2020	In our experiments ice nucleation in the LiI solution required the same supercooling as pure water, which is more consistent with our simulations.	Water	93-98	caspase 1	Homo sapiens	19-22
32512939-2	2020	Since AQP11 is an endoplasmic reticulum (ER)-resident protein that transports water, glycerol, and hydrogen peroxide (H2O2), we hypothesized that this superaquaporin is involved in ER stress induced by lipotoxicity and inflammation in human obesity.	Water	78-83	aquaporin 11	Homo sapiens	6-11
32390263-2	2020	Here, metal-organic framework (MOF)/polymer heterogeneous nanochannels are presented, in which water molecules are confined to disordered clusters in the nanometer-sized polymer regions and to ordered chains with unique molecular configurations in the 1D sub-1-nm porous MOF regions, to realize unidirectional, fast, and selective proton transport properties, analogous to natural proton channels.	Water	95-100	SUB1 regulator of transcription	Homo sapiens	255-260
32378412-8	2020	Besides, it is easier to generate H2O (WM) and a surface oxygen vacancy from the intermediate H2M/H4M than from H3M/H5M, which is related to the acid-base interaction between the HCe/M* and HO* in H2M/H4M.	Water	34-37	RNA guanylyltransferase and 5'-phosphatase	Homo sapiens	179-182
32290771-2	2020	LAC2 messenger RNA (mRNA) level was post-transcriptionally regulated by microRNA 397b, which showed increased expression under water and phosphate deficiency, resulting in the downregulation of LAC2 expression In this report, we have investigated root growth and lignin deposition in an economically important legume crop chickpea (Cicer arietinum L.) in response to natural drought in soil-grown condition.	Water	127-132	laccase 2	Arabidopsis thaliana	0-4
32513295-9	2020	CONCLUSIONS: The findings reported herein suggest that integrated snail control strategies should be considered to control snails via protection of water bodies from disturbance by anthropogenic activities.	Water	148-153	snail family transcriptional repressor 1	Homo sapiens	66-71
32347712-0	2020	Highly Sensitive Real-Time Isotopic Quantification of Water by ATR-FTIR.	Water	54-59	ATR serine/threonine kinase	Homo sapiens	63-66
32061786-1	2020	BACKGROUND: We previously showed that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is S-glutathionylated in the presence of H2O2 and GSH.	Water	128-132	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	38-78
32122155-6	2020	MEASURES: Dichotomous outcome variables were parental intentions to give child(ren) (1) more water and (2) less sugar-sweetened beverage consumption in their households.	Water	93-98	renin	Homo sapiens	47-50
33911740-1	2020	Background: Aquaporin 1 (AQP1) is a transmembrane channel protein that allows rapid transposition of water and gases, in recent discoveries of AQP1 function involve cell proliferation, differentiation, wound healing, inflammation and infection in different cell types, suggesting that AQP1 plays key roles in diverse biologic process.	Water	101-106	aquaporin 1 (Colton blood group)	Homo sapiens	12-23
33911740-1	2020	Background: Aquaporin 1 (AQP1) is a transmembrane channel protein that allows rapid transposition of water and gases, in recent discoveries of AQP1 function involve cell proliferation, differentiation, wound healing, inflammation and infection in different cell types, suggesting that AQP1 plays key roles in diverse biologic process.	Water	101-106	aquaporin 1 (Colton blood group)	Homo sapiens	25-29
33911740-1	2020	Background: Aquaporin 1 (AQP1) is a transmembrane channel protein that allows rapid transposition of water and gases, in recent discoveries of AQP1 function involve cell proliferation, differentiation, wound healing, inflammation and infection in different cell types, suggesting that AQP1 plays key roles in diverse biologic process.	Water	101-106	aquaporin 1 (Colton blood group)	Homo sapiens	143-147
33911740-1	2020	Background: Aquaporin 1 (AQP1) is a transmembrane channel protein that allows rapid transposition of water and gases, in recent discoveries of AQP1 function involve cell proliferation, differentiation, wound healing, inflammation and infection in different cell types, suggesting that AQP1 plays key roles in diverse biologic process.	Water	101-106	aquaporin 1 (Colton blood group)	Homo sapiens	143-147
32061786-1	2020	BACKGROUND: We previously showed that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is S-glutathionylated in the presence of H2O2 and GSH.	Water	128-132	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	80-85
32088457-5	2020	30% RM converted water-soluble NaF into more stable CaF2 than did SPL at 850  C, thus reducing the leaching rate by 45.15%.	Water	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
32346474-0	2020	Immunostimulatory effects of cell wall-based nanoparticles in boiled Glycyrrhizae radix water extracts involves TLR4.	Water	88-93	toll-like receptor 4	Mus musculus	112-116
32346474-8	2020	The results of the present study suggested that the signaling pathway of nanoparticles obtained from boiled Glycyrrhizae radix water extracts, at least partially involved TLR4 and downstream signaling from this receptor, resulting in the immunostimulatory effects of these nanoparticles in RAW-blue cells.	Water	127-132	toll-like receptor 4	Mus musculus	171-175
32371360-5	2020	We also show that the automated conformer and rotamer search algorithm CREST is able to correctly predict the metal binding position from a starting point consisting of separated peptide, copper and water.	Water	199-204	SS18L1 subunit of BAF chromatin remodeling complex	Homo sapiens	71-76
32496028-5	2020	Their 1 H water relaxivities r1 of these ORCAs were between 0.739 mM-1  s-1 (CD68) to 1.047 mM-1  s-1 (CD88) in D2 O/H2 O 9 : 1 (v : v) at 300 K. One of them (CD78) was tested on glioma-bearing rats with reduced side effects and good relaxivity in vivo.	Water	10-15	macrosialin	Orcinus orca	77-81
32163842-2	2020	Relating to this, we have recently discussed how the amount and state of water, accumulated within various hydrophobic-to-hydrophilic subsurface gradients of plasma polymer films, influence the magnitude of adsorbed bovine serum albumin, spurring the hypothesis of the presence of a subsurface dipolar field.	Water	73-78	albumin	Homo sapiens	223-236
32270402-12	2020	CONCLUSION: HSA-curcumin NPs increase curcumin solubility in water as well as its stability in physiological and acidic conditions.	Water	61-66	albumin	Homo sapiens	12-15
31811327-9	2020	Consistently, SAL protected cardiomyocytes against H2O2-induced H9c2 damage through increasing cell viability, decreasing cell apoptosis, and activating Trx and inhibiting JNK.	Water	51-55	thioredoxin 1	Rattus norvegicus	153-156
32170495-4	2020	Cold water samples yielded the most promising results, as shown by the recovery of the full set of 16 reproducible STR loci from the touch DNA sample of one test-person after 7 days.	Water	5-10	statherin	Homo sapiens	115-118
32463017-9	2020	The results strongly imply that magnetic tea waste has promising potential as an economic and excellent adsorbent for the removal of Pb(II) from water.	Water	145-150	submaxillary gland androgen regulated protein 3B	Homo sapiens	133-139
32432869-1	2020	The homodinuclear CoII helicate complex [CoII(DQPD)]2 (1) was prepared by treating [Co(H2O)6](ClO4)2 with the deprotonated form of the ligand N2,N6-bis(quinolin-8-yl)pyridine-2,6-dicarboxamide (DQPDH2).	Water	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
32432869-1	2020	The homodinuclear CoII helicate complex [CoII(DQPD)]2 (1) was prepared by treating [Co(H2O)6](ClO4)2 with the deprotonated form of the ligand N2,N6-bis(quinolin-8-yl)pyridine-2,6-dicarboxamide (DQPDH2).	Water	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
32391690-1	2020	Three mononuclear octahedral Co(II) complexes are reported, [Co(py)4(SCN)2] (1), [Co(py)4(Cl)2] H2O (2), and [Co(py)4(Br)2] (3), that exhibit different distortions with compression (1) or elongation (2 and 3) of the axial positions.	Water	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
32381599-10	2020	CONCLUSIONS: These data reveal novel functions for Pax proteins in adult renal epithelia that are essential for retaining water and concentrating urine.	Water	122-127	paxillin	Mus musculus	51-54
32160330-5	2020	RESULTS: In monoculture 1,25(OH)2 D3 suppressed CD4+ T-lymphocyte proliferation, increased the percentage of CD4+ FoxP3+ CD25+ FoxP3+ Tregs and enhanced IL-10 and TGF-beta1 production.	Water	28-33	CD4 molecule	Homo sapiens	48-51
32160330-5	2020	RESULTS: In monoculture 1,25(OH)2 D3 suppressed CD4+ T-lymphocyte proliferation, increased the percentage of CD4+ FoxP3+ CD25+ FoxP3+ Tregs and enhanced IL-10 and TGF-beta1 production.	Water	28-33	CD4 molecule	Homo sapiens	109-112
32160330-5	2020	RESULTS: In monoculture 1,25(OH)2 D3 suppressed CD4+ T-lymphocyte proliferation, increased the percentage of CD4+ FoxP3+ CD25+ FoxP3+ Tregs and enhanced IL-10 and TGF-beta1 production.	Water	28-33	transforming growth factor beta 1	Homo sapiens	163-172
31926603-12	2020	At the molecular levels, the effects of the phytogenic water additives seemed to be mediated by the activation of the hypothalamic AgRP-ORX-mTOR-S6k1 and inhibition of CRH pathways.	Water	55-60	mechanistic target of rapamycin	Gallus gallus	140-144
32486459-1	2020	Arginine vasopressin (Avp) is a conserved pleiotropic hormone that is known to regulate both water reabsorption and ion balance; however, many of the mechanisms underlying its effects remain unclear.	Water	93-98	arginine vasopressin	Homo sapiens	9-20
32120108-6	2020	The aim of this study was to identify the toxic effects that the pollutants present in the water of the Madin Dam can generate on a human cell line (SH SY5Y) evaluating the cell viability and the participation of the Aril Hydrocarbon Receptor (AhR) and Pregnane X receptor (PXR) through of the expression of the CYP1A1 and CYP3A4 (canonical genes).	Water	91-96	nuclear receptor subfamily 1 group I member 2	Homo sapiens	253-272
32120108-6	2020	The aim of this study was to identify the toxic effects that the pollutants present in the water of the Madin Dam can generate on a human cell line (SH SY5Y) evaluating the cell viability and the participation of the Aril Hydrocarbon Receptor (AhR) and Pregnane X receptor (PXR) through of the expression of the CYP1A1 and CYP3A4 (canonical genes).	Water	91-96	nuclear receptor subfamily 1 group I member 2	Homo sapiens	274-277
32120108-6	2020	The aim of this study was to identify the toxic effects that the pollutants present in the water of the Madin Dam can generate on a human cell line (SH SY5Y) evaluating the cell viability and the participation of the Aril Hydrocarbon Receptor (AhR) and Pregnane X receptor (PXR) through of the expression of the CYP1A1 and CYP3A4 (canonical genes).	Water	91-96	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	323-329
32627468-12	2020	Sijunzi Decoction water extract could reduce the Abeta_(25-35) oligomer-induced cytotoxicity of HBMEC, decrease the expression of RAGE mRNA and RAGE protein, and increase the expression of GLUT1 mRNA, LRP1 mRNA and LRP1 protein.	Water	18-23	LDL receptor related protein 1	Homo sapiens	201-205
32627468-12	2020	Sijunzi Decoction water extract could reduce the Abeta_(25-35) oligomer-induced cytotoxicity of HBMEC, decrease the expression of RAGE mRNA and RAGE protein, and increase the expression of GLUT1 mRNA, LRP1 mRNA and LRP1 protein.	Water	18-23	LDL receptor related protein 1	Homo sapiens	215-219
32173183-6	2020	Moreover, ultrasound-treated collagen had superior functional properties such as water, oil absorption capacity, water holding capacity, foaming and emulsifying properties than non-ultrasound treated collagen.	Water	81-86	collagen type III alpha 1 chain	Gallus gallus	29-37
32173183-6	2020	Moreover, ultrasound-treated collagen had superior functional properties such as water, oil absorption capacity, water holding capacity, foaming and emulsifying properties than non-ultrasound treated collagen.	Water	113-118	collagen type III alpha 1 chain	Gallus gallus	29-37
31923872-3	2020	The addition of MBP promoted the water holding capacity (WHC) and gel strength of SPI-MBP gels.	Water	33-38	chromogranin A	Homo sapiens	82-85
32486459-1	2020	Arginine vasopressin (Avp) is a conserved pleiotropic hormone that is known to regulate both water reabsorption and ion balance; however, many of the mechanisms underlying its effects remain unclear.	Water	93-98	arginine vasopressin	Homo sapiens	22-25
32486459-3	2020	After incubating embryos in double-deionized water for 24 h, avp mRNA expression levels were significantly upregulated.	Water	45-50	arginine vasopressin	Danio rerio	61-64
32469934-0	2020	Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells.	Water	50-55	CF transmembrane conductance regulator	Homo sapiens	76-80
32486031-2	2020	We have recently provided in vitro evidence that, compared to V2R-wt, expression of activating V2R mutations R137L, R137C and F229V cause a constitutive redistribution of the AQP2 water channel to the plasma membrane, higher basal water permeability and significantly higher basal levels of p256-AQP2 in the F229V mutant but not in R137L or R137C.	Water	180-185	arginine vasopressin receptor 2	Homo sapiens	95-98
32486031-2	2020	We have recently provided in vitro evidence that, compared to V2R-wt, expression of activating V2R mutations R137L, R137C and F229V cause a constitutive redistribution of the AQP2 water channel to the plasma membrane, higher basal water permeability and significantly higher basal levels of p256-AQP2 in the F229V mutant but not in R137L or R137C.	Water	231-236	arginine vasopressin receptor 2	Homo sapiens	95-98
32469934-11	2020	We identified a CFTR and cAMP-dependent, mercury-sensitive water transport in airway epithelial and CHO cells that might be due to AQP3.	Water	59-64	aquaporin-3	Cricetulus griseus	131-135
32393646-8	2020	Upon illumination under 1 sun, the surface temperature can increase by 53  C, so that no ice can form at an environmental temperature as low as -50  C and it can also rapidly melt the accumulated frost and ice in 300 s. The superhydrophobicity enables the melted water to slide away immediately, leaving a clean and dry surface.	Water	263-268	carboxylesterase 2	Homo sapiens	206-209
32550602-6	2020	Both NH4 + and NO3 - can be produced in pure water under a simulated solar light and even till the wavelength reaching 730 nm.	Water	45-50	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
32374155-3	2020	To accelerate water removal and gas permeation, ammonium chloride was utilized to improve the porous structure of MPL.	Water	14-19	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	114-117
32452832-5	2020	We show that both in liquid silicon and SW model of water the frequencies of longitudinal excitations slightly increase with temperature which is in contrast to the results for SPC/E model of water.	Water	192-197	surfactant protein C	Homo sapiens	177-180
32550602-4	2020	In this work, we report a strategy to photocatalytically fix nitrogen through simultaneous reduction and oxidation to produce NH4 + and NO3 - by W18O49 nanowires in pure water.	Water	170-175	NBL1, DAN family BMP antagonist	Homo sapiens	136-139
32468296-0	2020	A smartphone-based platform for point-of-use determination of alkaline phosphatase as an indicator of water eutrophication.	Water	102-107	alkaline phosphatase, placental	Homo sapiens	62-82
32508841-4	2020	We report that T cells activation is inhibited and EAU is attenuated in human KBP (HKBP) mice with no significant difference in the Treg population that we previously identified both before and after recovery from EAU.	Water	51-54	kinesin family binding protein	Homo sapiens	78-81
32548400-4	2020	Addition of isopropanol could stabilize the pollution grade of particles with size >=30 mum (c) at the same level, which is most obviously affected by free water without isopropanol.	Water	156-161	latexin	Homo sapiens	88-91
32432927-3	2020	The ability to increase the levels of AQP2 in the apical plasma membrane following an increase in plasma osmolality is a rate-limiting step in water reabsorption, a process that is tightly regulated by the antidiuretic hormone arginine vasopressin (AVP).	Water	143-148	arginine vasopressin	Homo sapiens	236-247
32014500-6	2020	The elevated levels of H2O2 (a biomarker of oxidative stress) and the free radicals (NO  and O2 -) reduced the concentration of dominant pathogens and regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1).	Water	23-27	mechanistic target of rapamycin kinase	Homo sapiens	205-209
32014500-6	2020	The elevated levels of H2O2 (a biomarker of oxidative stress) and the free radicals (NO  and O2 -) reduced the concentration of dominant pathogens and regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1).	Water	23-27	RUNX family transcription factor 2	Homo sapiens	239-274
32014500-6	2020	The elevated levels of H2O2 (a biomarker of oxidative stress) and the free radicals (NO  and O2 -) reduced the concentration of dominant pathogens and regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1).	Water	23-27	RUNX family transcription factor 2	Homo sapiens	276-281
32014500-6	2020	The elevated levels of H2O2 (a biomarker of oxidative stress) and the free radicals (NO  and O2 -) reduced the concentration of dominant pathogens and regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1).	Water	23-27	mitogen-activated protein kinase 8	Homo sapiens	284-309
32014500-6	2020	The elevated levels of H2O2 (a biomarker of oxidative stress) and the free radicals (NO  and O2 -) reduced the concentration of dominant pathogens and regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1).	Water	23-27	mitogen-activated protein kinase 8	Homo sapiens	311-314
32014500-6	2020	The elevated levels of H2O2 (a biomarker of oxidative stress) and the free radicals (NO  and O2 -) reduced the concentration of dominant pathogens and regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1).	Water	23-27	mechanistic target of rapamycin kinase	Homo sapiens	316-345
32014500-6	2020	The elevated levels of H2O2 (a biomarker of oxidative stress) and the free radicals (NO  and O2 -) reduced the concentration of dominant pathogens and regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1).	Water	23-27	mechanistic target of rapamycin kinase	Homo sapiens	347-351
32432927-3	2020	The ability to increase the levels of AQP2 in the apical plasma membrane following an increase in plasma osmolality is a rate-limiting step in water reabsorption, a process that is tightly regulated by the antidiuretic hormone arginine vasopressin (AVP).	Water	143-148	arginine vasopressin	Homo sapiens	249-252
32436113-2	2020	PPy-CS2 combines pH-dependent chelation, extraction, and desorption sorbent properties that are exploited for the selective extraction and sensitive determination of heavy metals in water matrices using ultrasound-assisted dispersive micro solid-phase extraction and inductively coupled plasma mass spectrometry.	Water	182-187	chorionic somatomammotropin hormone 2	Homo sapiens	4-7
32336093-2	2020	Using a simplified model of the pore of the 5HT3 receptor (5HT3R) which restrains the backbone structure to that of the parent channel protein from which it is derived we compare additive with polarizable models in describing the behavior of water in nanopores.	Water	242-247	5-hydroxytryptamine receptor 3A	Homo sapiens	44-57
32336093-2	2020	Using a simplified model of the pore of the 5HT3 receptor (5HT3R) which restrains the backbone structure to that of the parent channel protein from which it is derived we compare additive with polarizable models in describing the behavior of water in nanopores.	Water	242-247	5-hydroxytryptamine receptor 3A	Homo sapiens	59-64
32348134-3	2020	Results showed that oxidative modification increased the gel hardness as well as brought about a compact and three-dimensional network structure, which consequently decreased the water mobility as manifest by lowering the relaxation time of T2b and T21 from 0.55 ms and 3.22 ms for control to 0.32 ms and 2.42 ms for 7LA+LOX (addition of 7 mL LA and LOX), respectively.	Water	179-184	seed linoleate 9S-lipoxygenase-3	Glycine max	321-324
32348134-3	2020	Results showed that oxidative modification increased the gel hardness as well as brought about a compact and three-dimensional network structure, which consequently decreased the water mobility as manifest by lowering the relaxation time of T2b and T21 from 0.55 ms and 3.22 ms for control to 0.32 ms and 2.42 ms for 7LA+LOX (addition of 7 mL LA and LOX), respectively.	Water	179-184	seed linoleate 9S-lipoxygenase-3	Glycine max	338-353
32775816-12	2020	In addition, endothelial changes mediated via interleukin (IL)-6 and vascular endothelial growth factor (VEGF) that lead to vascular hyperpermeability and water leakage might contribute to anasarca, because molecular-targeting therapy directed against IL-6 or VEGF improved renal dysfunction and severe endothelial damage.	Water	155-160	interleukin 6	Homo sapiens	46-64
32329336-5	2020	The limit of detection of PFOA in ultrapure water was 11.0 ng L-1.	Water	44-49	L1 cell adhesion molecule	Homo sapiens	62-65
32775816-12	2020	In addition, endothelial changes mediated via interleukin (IL)-6 and vascular endothelial growth factor (VEGF) that lead to vascular hyperpermeability and water leakage might contribute to anasarca, because molecular-targeting therapy directed against IL-6 or VEGF improved renal dysfunction and severe endothelial damage.	Water	155-160	vascular endothelial growth factor A	Homo sapiens	69-103
32775816-12	2020	In addition, endothelial changes mediated via interleukin (IL)-6 and vascular endothelial growth factor (VEGF) that lead to vascular hyperpermeability and water leakage might contribute to anasarca, because molecular-targeting therapy directed against IL-6 or VEGF improved renal dysfunction and severe endothelial damage.	Water	155-160	vascular endothelial growth factor A	Homo sapiens	105-109
32297632-9	2020	The inversion of the stereochemistry at the C1  of the AP-site indicates that a nucleophilic water molecule approaches from the back of the thymine substrate, suggesting a bimolecular displacement mechanism (SN2) for hMBD4-catalyzed thymine excision.	Water	93-98	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	217-222
32390535-1	2020	Background Arginine vasopressin dependent antidiuresis plays a key role in water-sodium retention in heart failure.	Water	75-80	arginine vasopressin	Rattus norvegicus	20-31
32250815-2	2020	This could lead to increased nitrate (NO3-) leaching when water scarcity affects the N-uptake capacity of trees and increases soil N availability due to early leaf senescence and higher litter input.	Water	58-63	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
32250815-5	2020	We found that in the year after a summer drought, NO3- leaching via soil water seepage was significantly elevated compared to the long-term mean.	Water	73-78	NBL1, DAN family BMP antagonist	Homo sapiens	50-53
32419985-5	2020	The main chemical components of PM2.5 near the surface in the forest were SO4 2- and NO3 -, which accounted for 68.72% of all water-soluble ions that we observed.	Water	126-131	NBL1, DAN family BMP antagonist	Homo sapiens	85-88
32265297-9	2020	An analysis of water access channels revealed only a few diffusion trajectories for the catalytically active form of OTUB1, whereas in OTUB2 the catalytic site was solvent accessible, and a larger number of water molecules reached and left the binding pocket.	Water	15-20	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	117-122
32265297-9	2020	An analysis of water access channels revealed only a few diffusion trajectories for the catalytically active form of OTUB1, whereas in OTUB2 the catalytic site was solvent accessible, and a larger number of water molecules reached and left the binding pocket.	Water	207-212	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	117-122
32392117-26	2021	Interestedly, the supplementation with water soluble vitamins (folate, Vit.	Water	39-44	vitrin	Homo sapiens	71-74
32457871-0	2020	Hybrid Molecular Dynamics for Elucidating Cooperativity Between Halogen Bond and Water Molecules During the Interaction of p53-Y220C and the PhiKan5196 Complex.	Water	81-86	tumor protein p53	Homo sapiens	123-126
32457871-3	2020	In this study, the Y220C-PhiKan5196 complex of p53 protein was adopted as a model, and the functions of three water molecules that formed hydrogen bonds with halogen atoms were analyzed by the simulation method governed by the hybrid quantum mechanical/molecular mechanical molecular dynamics.	Water	110-115	tumor protein p53	Homo sapiens	47-50
32455232-7	2020	TG-MS analysis results show that the thermal decomposition products of F2602/GAP/CL-20 are mainly C2H6, H2O, N2, and CO2.	Water	104-107	epithelial membrane protein 1	Homo sapiens	81-86
32301615-1	2020	Hydrophilic host-guest complexes, consisting in a water-soluble azobenzene and alpha-, beta- or gamma-cyclodextrins, have been proposed as a model to study supramolecular photoresponsive systems in aqueous environments through a full spectrometric approach combined to a simulation and data fitted methodology.	Water	50-55	amyloid beta precursor protein	Homo sapiens	48-49
32113565-3	2020	This has led the European Union and other global organizations to reduce the maximum residue limit for the total arsenic up to 10 mug L-1 in water for human consumption.	Water	141-146	immunoglobulin kappa variable 1-16	Homo sapiens	134-137
32422879-5	2020	Overexpressed cardiac corin also significantly modulated heart function (ejection fraction, p < 0.0001), lung congestion (lung weight to body weight ratio, p < 0.0001), and systemic extracellular water (edema, p < 0.05) during late phase post-MI.	Water	196-201	corin, serine peptidase	Mus musculus	22-27
31782790-9	2020	Furthermore, H2O2 increased PD-1 expression on CD8+ T-cells, compromising their cytotoxic capacity assessed by perforin expression, similar to IH.	Water	13-17	MHC class I antigen 1	Sus scrofa	28-32
31310829-2	2020	AIM OF THE STUDY: The aim of this study was to evaluate the anti-inflammatory activities of Eriobotrya japonica (EJ) leaf water extract in an ovalbumin (OVA)-induced murine asthma model and human tracheal smooth muscle cell (HTSMC).	Water	122-127	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	142-151
32455249-8	2020	Mice maintained on water containing 0.5% NMT for several days lead to the distribution of the taurine derivative to various tissues, including skeletal muscles.	Water	19-24	N-myristoyltransferase 1	Homo sapiens	41-44
32455249-11	2020	Similarly, the addition of 0.5% NMT to drinking water attenuates dexamethasone-mediated reduction in muscle mass of the treated mice.	Water	48-53	N-myristoyltransferase 1	Homo sapiens	32-35
32608844-6	2020	The total concentrations of antibiotics in surface water ranged from 1.12 ng L-1 to 53.74 ng L-1.	Water	51-56	L1 cell adhesion molecule	Homo sapiens	77-80
32608844-6	2020	The total concentrations of antibiotics in surface water ranged from 1.12 ng L-1 to 53.74 ng L-1.	Water	51-56	L1 cell adhesion molecule	Homo sapiens	93-96
32322864-4	2020	Besides, the band edge positions of the CdO/CdS HT of 0  are energetically favorable for overall water-splitting processes with the pH scope of 0-3.6.	Water	97-102	cell adhesion associated, oncogene regulated	Homo sapiens	40-43
32322864-5	2020	Therefore, the CdO/CdS HT is a promising photocatalyst to split water.	Water	64-69	cell adhesion associated, oncogene regulated	Homo sapiens	15-18
32251594-0	2020	Structure Determination of Hen Egg-White Lysozyme Aggregates Adsorbed to Lipid/Water and Air/Water Interfaces.	Water	79-84	lysozyme	Homo sapiens	41-49
32380695-7	2020	EAU induction increased the levels of cytokines (interleukin (IL)-1alpha, IL-1beta, IL-4, IL-6, IL-12, IL-17, and tumor necrosis factor (TNF)-alpha) and chemokines (monocyte chemoattractant protein (MCP)-1) in the retinas of wild-type mice but not in those of Ncf1-/- mice.	Water	0-3	interleukin 6	Mus musculus	90-94
32380695-7	2020	EAU induction increased the levels of cytokines (interleukin (IL)-1alpha, IL-1beta, IL-4, IL-6, IL-12, IL-17, and tumor necrosis factor (TNF)-alpha) and chemokines (monocyte chemoattractant protein (MCP)-1) in the retinas of wild-type mice but not in those of Ncf1-/- mice.	Water	0-3	tumor necrosis factor	Mus musculus	114-147
32251594-0	2020	Structure Determination of Hen Egg-White Lysozyme Aggregates Adsorbed to Lipid/Water and Air/Water Interfaces.	Water	93-98	lysozyme	Homo sapiens	41-49
31960754-3	2020	ALP treatment was shown to induce concentration-dependent antioxidant activity in HT22 cells, and to increase cell viability in H2O2-treated HT22 cells.	Water	128-132	alopecia, recessive	Mus musculus	0-3
32174138-1	2020	Emerging evidence has demonstrated that (pro)renin receptor (PRR)-mediated activation of intrarenal renin-angiotensin system (RAS) plays an essential role in renal handling of Na+ and water balance and blood pressure.	Water	184-189	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	61-64
32250753-0	2020	Nano-manganese oxide-functionalized-oleyl amine as a simple and low cost nanosorbent for remediation of ZnII/CoII and their radioactive nuclides 65Zn and 60Co from water.	Water	164-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
31960754-5	2020	Mediators of the intracellular response to oxidation, including Bax, cytochrome c, and cleaved caspases-3, -8, -9, MAPKs, and NF-kappaB, were positively influenced by ALP treatment under conditions of H2O2-mediated oxidative stress.	Water	201-205	alopecia, recessive	Mus musculus	167-170
31960754-6	2020	In addition, ALP restored the expression of superoxide dismutase (SOD) and associated signaling pathways (PARP, PI3K/AKT and Nrf2-mediated HO-1/NQO-1) following H2O2 treatment.	Water	161-165	alopecia, recessive	Mus musculus	13-16
32449828-3	2020	The deprotected fully water-soluble anionic phosphate-based polypeptides showed pH-dependent helical conformation with a helical content of 20 %, which further changed to beta-sheets upon addition of the enzyme alkaline phosphatase (ALP) due to dephosphorylation.	Water	22-27	alkaline phosphatase, placental	Homo sapiens	211-231
32449828-3	2020	The deprotected fully water-soluble anionic phosphate-based polypeptides showed pH-dependent helical conformation with a helical content of 20 %, which further changed to beta-sheets upon addition of the enzyme alkaline phosphatase (ALP) due to dephosphorylation.	Water	22-27	alkaline phosphatase, placental	Homo sapiens	233-236
32187698-0	2020	In Situ Investigation of Performance Reference Compound-Based Estimates of PCB Equilibrated Passive Sampler Concentrations and Cfree in the Marine Water Column.	Water	147-152	pyruvate carboxylase	Homo sapiens	75-78
31912910-11	2020	These findings suggested that GLA protected against H2 O2 -induced oxidative stress and inflammation via inhibition of p38 phosphorylation and NF-kappaB activation in HCASMCs.	Water	52-57	mitogen-activated protein kinase 14	Homo sapiens	119-122
32151840-2	2020	The mean NO3-N concentration in groundwater was 7.373 mg/L, which is approximately 1.9 times higher than concentrations found in stream water.	Water	38-43	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
32151840-6	2020	The NO3-N load in stream water to that in groundwater (R) was higher during the wet season (September) than the dry season (March), with R distinctly increasing in upstream areas relative to downstream areas, indicating that during the wet season, a large amount of NO3-N is introduced into stream water from groundwater.	Water	25-30	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
32052323-3	2020	Water-soluble ionic contents were also more distributed in PM1.1 with the great contents of secondary particles (NO3-, SO42-, and NH4+).	Water	0-5	NBL1, DAN family BMP antagonist	Homo sapiens	113-116
31698947-4	2020	METHODS: ApoE-/- mice were fed a high-fat diet with Hcy in drinking water to induce atherosclerotic calcification.	Water	68-73	apolipoprotein E	Mus musculus	9-13
32203804-2	2020	Ferrate (FeO42-, Fe(VI)) was used to pre-oxidize natural organic matter (NOM, the precursor of DBPs) in source water to control DBP formation in subsequent chlorine or chloramine disinfection.	Water	111-116	D-box binding PAR bZIP transcription factor	Homo sapiens	95-98
32247441-2	2020	Plant-based milk substitutes, or plant extracts, are water-soluble extracts of legumes, oilseeds, cereals or pseudocereals that resemble bovine milk in appearance.	Water	53-58	Weaning weight-maternal milk	Bos taurus	12-16
32219907-1	2020	Vasopressin regulates renal water excretion by binding to a Galpha s-coupled receptor (V2R) in collecting duct cells, resulting in increased water permeability through regulation of the aquaporin-2 (AQP2) water channel.	Water	28-33	arginine vasopressin	Homo sapiens	0-11
32219907-1	2020	Vasopressin regulates renal water excretion by binding to a Galpha s-coupled receptor (V2R) in collecting duct cells, resulting in increased water permeability through regulation of the aquaporin-2 (AQP2) water channel.	Water	141-146	arginine vasopressin	Homo sapiens	0-11
32219907-1	2020	Vasopressin regulates renal water excretion by binding to a Galpha s-coupled receptor (V2R) in collecting duct cells, resulting in increased water permeability through regulation of the aquaporin-2 (AQP2) water channel.	Water	141-146	arginine vasopressin	Homo sapiens	0-11
32342434-9	2020	The cuticular wax provides an essential barrier for decreasing nonstomatal water loss during drought stress, so overexpression of AtDBP1 showed decreased drought tolerance possibly ascribed to the change of cuticle membrane structure.	Water	75-80	DNA-binding protein phosphatase 1	Arabidopsis thaliana	130-136
32040235-0	2020	Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway.	Water	14-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	83-87
32396807-1	2020	Passive interception of fog from the wind is an effective solution for accessing water in regions where fog is frequent and other sources scarce.	Water	81-86	zinc finger protein, FOG family member 1	Homo sapiens	24-27
32396807-1	2020	Passive interception of fog from the wind is an effective solution for accessing water in regions where fog is frequent and other sources scarce.	Water	81-86	zinc finger protein, FOG family member 1	Homo sapiens	104-107
32172966-6	2020	The MCH is employed to treat surface water that contains 10 mg/L of NO3-, and it is found that the optimal magnetic separation time is 1.6 min.	Water	37-42	NBL1, DAN family BMP antagonist	Homo sapiens	68-71
32016793-6	2020	The results indicated that DDW could attenuate H2O2-induced apoptosis, reduce ROS formation, and increase CAT, CuZn-SOD and SOD activity in H2O2-treated PC12 cells.	Water	140-144	superoxide dismutase 1	Rattus norvegicus	116-119
32357181-6	2020	The prolonged water deficit also led to increased relative membrane permeability and oxidative stress induced by the production of malondialdehyde (from lipid peroxidation), lipoxygenase activity (LOX) and the production of H2O2.	Water	14-19	linoleate 9S-lipoxygenase1	Zea mays	197-200
32239008-0	2020	Hot-water extract of ripened Pu-erh tea attenuates DSS-induced colitis through modulation of the NF-kappaB and HIF-1alpha signaling pathways in mice.	Water	4-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
32311236-4	2020	Most importantly, the O-Co0.5 Mo0.5 Se2   O-Co0.5 Mo0.5 Se2 water splitting device only entails a voltage of  1.53 V at a current density of 10 mA cm-2 , which is much better than benchmark Pt/C  RuO2 ( 1.56 V).	Water	60-65	fucosyltransferase 2	Homo sapiens	36-39
32311236-4	2020	Most importantly, the O-Co0.5 Mo0.5 Se2   O-Co0.5 Mo0.5 Se2 water splitting device only entails a voltage of  1.53 V at a current density of 10 mA cm-2 , which is much better than benchmark Pt/C  RuO2 ( 1.56 V).	Water	60-65	fucosyltransferase 2	Homo sapiens	56-59
32196541-10	2020	Furthermore, mulberry leaf water extracts could reduce the serum free fatty acid (FFA), tumor necrosis factor-alpha (TNF-alpha), insulin and glycated serum protein content, while alleviating kidney damage and improving intestinal microbiota.	Water	27-32	tumor necrosis factor	Mus musculus	88-115
32250438-5	2020	Such sites would contribute to formation of the hydrophobic ET pathway from Cyt c to CcO by blocking water access from the bulk water phase.	Water	101-106	cytochrome c, somatic	Homo sapiens	76-81
32196541-10	2020	Furthermore, mulberry leaf water extracts could reduce the serum free fatty acid (FFA), tumor necrosis factor-alpha (TNF-alpha), insulin and glycated serum protein content, while alleviating kidney damage and improving intestinal microbiota.	Water	27-32	tumor necrosis factor	Mus musculus	117-126
32250438-5	2020	Such sites would contribute to formation of the hydrophobic ET pathway from Cyt c to CcO by blocking water access from the bulk water phase.	Water	128-133	cytochrome c, somatic	Homo sapiens	76-81
32425919-5	2020	After PD-1 antibody treatment, the injection of antibiotics counteracted the efficacy of PD-1 antibody in inhibiting tumor growth when compared with the Control group (mice were treated with sterile drinking water).	Water	208-213	programmed cell death 1	Mus musculus	89-93
32382681-1	2020	The redox kinetics involving the reaction of N, N"-phenylenebis(salicyalideneiminato)cobalt(III) ([CoSalophen]+) and l-cysteine (LSH) was studied using pseudo-first order approach under the following conditions, [H+] = 1.0 x 10-3 mol/dm3, mu = 0.1 C2 mol/dm3 (NaCl), lambdamax = 470 nm and T = 27 +- 1  C in DMSO: H2O; 1:4 v: v medium.	Water	314-317	helicase, lymphoid specific	Homo sapiens	129-132
32478672-9	2020	DI was confirmed by water restriction test and treated with vasopressin with great clinical results.	Water	20-25	arginine vasopressin	Homo sapiens	60-71
32255608-9	2020	Moreover, when exposed to a fouling solution containing bovine serum albumin (BSA), these dual-functional membranes exhibited an 18% decline in normalized flux and recovered 99% of their flux upon rinsing with water.	Water	210-215	albumin	Homo sapiens	63-76
32321261-5	2020	We compare the experimental results to the results of computer simulations of two models of water (SPC/E and TIP4P) and show that the SPC/E model is not appropriate at high pressure, while the TIP4P model describes the equation of state of water, but fails to describe the heat capacity.	Water	92-97	surfactant protein C	Homo sapiens	99-102
32065645-0	2020	Expression of Concern: "Cadmium Induces Intracellular Ca2+- and H2O2-Dependent Apoptosis through JNK- and p53-Mediated Pathways in Skin Epidermal Cell line".	Water	64-68	mitogen-activated protein kinase 8	Homo sapiens	97-100
32065645-0	2020	Expression of Concern: "Cadmium Induces Intracellular Ca2+- and H2O2-Dependent Apoptosis through JNK- and p53-Mediated Pathways in Skin Epidermal Cell line".	Water	64-68	tumor protein p53	Homo sapiens	106-109
32344554-0	2020	Using Principal Components Analysis and IDW Interpolation to Determine Spatial and Temporal Changes of Surface Water Quality of Xin"anjiang River in Huangshan, China.	Water	111-116	xin actin binding repeat containing 1	Homo sapiens	128-131
32344554-1	2020	This study was aimed at assessing the spatial and temporal distribution of surface water quality variables of the Xin"anjiang River (Huangshan).	Water	83-88	xin actin binding repeat containing 1	Homo sapiens	114-117
32344554-6	2020	PCA technology identified important water quality parameters and revealed that nutrient pollution and organic pollution are major latent factors which influence the water quality of Xin"anjiang River.	Water	36-41	xin actin binding repeat containing 1	Homo sapiens	182-185
32344554-6	2020	PCA technology identified important water quality parameters and revealed that nutrient pollution and organic pollution are major latent factors which influence the water quality of Xin"anjiang River.	Water	165-170	xin actin binding repeat containing 1	Homo sapiens	182-185
32344554-8	2020	It is of great significance for water quality safety management and pollution control of the Xin"anjiang River.	Water	32-37	xin actin binding repeat containing 1	Homo sapiens	93-96
32344554-10	2020	Based on this, the temporal and spatial structure and changing characteristics of water quality in the Xin"anjiang River were analyzed.	Water	82-87	xin actin binding repeat containing 1	Homo sapiens	103-106
32344554-11	2020	We found that the overall water quality of Xin"anjiang River (Huangshan) was stable from 2008 to 2017, but the pollution of the Pukou sampling point was of great concern.	Water	26-31	xin actin binding repeat containing 1	Homo sapiens	43-46
32344554-14	2020	It was of great significance for the control of water pollution in Xin"anjiang River and the reduction of eutrophication pressure in Thousand Island Lake.	Water	48-53	xin actin binding repeat containing 1	Homo sapiens	67-70
32250625-1	2020	Gas hydrate forms when the hydrogen bonded crystal structure of water entraps small-sized gas molecules at relatively low temperature and high pressure.	Water	64-69	PAXIP1 associated glutamate rich protein 1	Homo sapiens	0-3
32250625-1	2020	Gas hydrate forms when the hydrogen bonded crystal structure of water entraps small-sized gas molecules at relatively low temperature and high pressure.	Water	64-69	PAXIP1 associated glutamate rich protein 1	Homo sapiens	90-93
32373171-0	2020	Assessment of Changes in Concentration of Total Antioxidant Status, Acute-Phase Protein, and Prolactin in Patients with Osteoarthritis Subjected to a Complex Spa Treatment with Radon Water: Preliminary Results.	Water	183-188	prolactin	Homo sapiens	93-102
32377206-12	2020	In the case-control study, 55% (59/107) of case-persons and 18% (19/107) of controls had stagnant water around households for several days following rainfall (ORM-H = 5.6, 95% CI = 3.0-11); 25% (27/107) of case-persons and 51% (55/107) of controls wore full extremity covering clothes during evening hours (ORM-H = 0.30, 95% CI = 0.20-0.60); 71% (76/107) of case-persons and 85% (91/107) of controls slept under a long-lasting insecticide-treated net (LLIN) 14 days before symptom onset (ORM-H = 0.43, 95% CI = 0.22-0.85); 37% (40/107) of case-persons and 52% (56/107) of controls had access to at least one LLIN per 2 household members (ORM-H = 0.54, 95% CI = 0.30-0.97).	Water	98-103	orosomucoid 1	Homo sapiens	159-162
32223124-3	2020	Here, we show that a dHDL-relevant complex can also be prepared by gently mixing 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and apoA-I or its mutants in ethanol/H2O solutions containing urea in the order of a few molar, and then incubating the mixture at the gel-liquid crystalline phase transition temperature in test tubes.	Water	169-172	apolipoprotein A1	Homo sapiens	136-142
32202106-8	2020	After the treatment, the effect of the produced water on DBP formation was largely eliminated.	Water	48-53	D-box binding PAR bZIP transcription factor	Homo sapiens	57-60
32321261-5	2020	We compare the experimental results to the results of computer simulations of two models of water (SPC/E and TIP4P) and show that the SPC/E model is not appropriate at high pressure, while the TIP4P model describes the equation of state of water, but fails to describe the heat capacity.	Water	92-97	surfactant protein C	Homo sapiens	134-137
32377523-3	2020	Previous work indicated that low concentrations of carrageenan in drinking water caused marked glucose intolerance and insulin resistance in a mouse model.	Water	75-80	insulin	Homo sapiens	119-126
32373535-1	2020	Background: Aquaporin 1 (AQP-1), a transmembrane water channel protein, has been proven to involve in many diseases" progression and prognosis.	Water	49-54	aquaporin 1 (Colton blood group)	Homo sapiens	12-23
32373535-1	2020	Background: Aquaporin 1 (AQP-1), a transmembrane water channel protein, has been proven to involve in many diseases" progression and prognosis.	Water	49-54	aquaporin 1 (Colton blood group)	Homo sapiens	25-30
32315300-0	2020	Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity.	Water	140-145	potassium voltage-gated channel subfamily A member 2	Homo sapiens	109-114
32315300-7	2020	Here, we show that two residues E327 and H418 in the proximity of the water cavity of Kv1.2 play crucial roles as a pH switch.	Water	70-75	potassium voltage-gated channel subfamily A member 2	Homo sapiens	86-91
32315300-8	2020	In addition, we present a structural and molecular concept of the pH-dependent gating of Kv1.2 in atomic detail, showing that the protonation of E327 and H418 disrupts the electrostatic balance around the S6 helices, which leads to a straightening transition in the shape of their axes and causes dewetting of the water-filled cavity and closure of the channel.	Water	314-319	potassium voltage-gated channel subfamily A member 2	Homo sapiens	89-94
32056967-5	2020	The super-sensitive colorimetric process produced linear regression equation for H2O2 as A = 0.00105C + 0.0630 (C:muM, R2 = 0.9961) with a detection limit of 0.052 muM, whereas for glucose, the linear relationship was A = 0.00084C + 0.0458 (C:muM, R2 = 0.9952) having a detection limit of 0.055 muM.	Water	81-85	latexin	Homo sapiens	114-117
32191033-2	2020	The fluorescence excitation-emission matrix spectra of the water-soluble components of cigarette smoke condensate and WSP (Cig-WS and Wood-WS) approximated those for the standard reference materials, Suwanee River and Nordic fulvic acids (SRFA and NFA).	Water	59-64	fibronectin 1	Homo sapiens	123-126
32197041-4	2020	We propose a new scaling tau~(rhomuR04/gamma2)1/3=(R0/v0)We2/3Re-1/3 to characterize the viscosity effect, which well agrees with the simulated results for water and argon nanodroplets with various radii and hydrophobicities.	Water	156-161	tryptophanyl-tRNA synthetase 1	Homo sapiens	30-47
32207949-8	2020	However, it unfolds in water medium at 450 K. It is found that the hydrogen bonding interactions between c-kit G-quadruplex DNA and reline play a key role in the stabilization of the G-quadruplex DNA even at high temperature.	Water	23-28	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	105-110
32209611-1	2020	Magnocellular neurosecretory cells are intrinsically osmosensitive and can be activated by increases in blood osmolality, triggering the release of antidiuretic hormone vasopressin (VP) to promote water retention.	Water	197-202	arginine vasopressin	Rattus norvegicus	169-180
32209611-1	2020	Magnocellular neurosecretory cells are intrinsically osmosensitive and can be activated by increases in blood osmolality, triggering the release of antidiuretic hormone vasopressin (VP) to promote water retention.	Water	197-202	arginine vasopressin	Rattus norvegicus	182-184
32063362-4	2020	Human lens epithelial cells expressing AQP1, AQP5 and AQP8, when treated with 50 muM HgCl2 water channel inhibitor showed a significant reduction in H2O2 transport.	Water	91-96	aquaporin 1 (Colton blood group)	Homo sapiens	39-43
32063362-4	2020	Human lens epithelial cells expressing AQP1, AQP5 and AQP8, when treated with 50 muM HgCl2 water channel inhibitor showed a significant reduction in H2O2 transport.	Water	91-96	aquaporin 8	Homo sapiens	54-58
32056967-5	2020	The super-sensitive colorimetric process produced linear regression equation for H2O2 as A = 0.00105C + 0.0630 (C:muM, R2 = 0.9961) with a detection limit of 0.052 muM, whereas for glucose, the linear relationship was A = 0.00084C + 0.0458 (C:muM, R2 = 0.9952) having a detection limit of 0.055 muM.	Water	81-85	latexin	Homo sapiens	164-167
32157865-5	2020	Here, we suggest a new strategy to fabricate PI sponges in water by introducing a suitable surfactant, sodium dodecylbenzenesulfonate (SDBS) (sPI sponges).	Water	59-64	chromogranin A	Homo sapiens	142-145
32056967-5	2020	The super-sensitive colorimetric process produced linear regression equation for H2O2 as A = 0.00105C + 0.0630 (C:muM, R2 = 0.9961) with a detection limit of 0.052 muM, whereas for glucose, the linear relationship was A = 0.00084C + 0.0458 (C:muM, R2 = 0.9952) having a detection limit of 0.055 muM.	Water	81-85	latexin	Homo sapiens	164-167
32056967-5	2020	The super-sensitive colorimetric process produced linear regression equation for H2O2 as A = 0.00105C + 0.0630 (C:muM, R2 = 0.9961) with a detection limit of 0.052 muM, whereas for glucose, the linear relationship was A = 0.00084C + 0.0458 (C:muM, R2 = 0.9952) having a detection limit of 0.055 muM.	Water	81-85	latexin	Homo sapiens	164-167
32216372-3	2020	SIFSIX-23-Cu exhibits reversible switching between non-porous (beta1) and several porous (alpha, gamma1, gamma2 and gamma3) phases triggered by exposure to N2, CO2 or H2O.	Water	167-170	tryptophanyl-tRNA synthetase 1	Homo sapiens	97-122
32150682-5	2020	The capabilities of the present approach are demonstrated for liquid water using MD trajectories calculated from the SPC/E model and the polarizable water model for intramolecular and intermolecular vibrational spectroscopies (POLI2VS) by determining the system parameters describing the symmetric-stretch, asymmetric-stretch, and bend modes with intramolecular interactions and the bath spectral distribution functions for each intramolecular mode representing the interaction with the intramolecular modes.	Water	69-74	proline rich protein gene cluster	Homo sapiens	117-120
32295252-0	2020	Aldosterone Decreases Vasopressin-Stimulated Water Reabsorption in Rat Inner Medullary Collecting Ducts.	Water	45-50	arginine vasopressin	Rattus norvegicus	22-33
32295252-2	2020	However, the direct effect of aldosterone on vasopressin-regulated water and urea permeability in the rat inner medullary collecting duct (IMCD) has not been tested.	Water	67-72	arginine vasopressin	Rattus norvegicus	45-56
32035614-5	2020	DFX also showed the inhibition effect on the activation of c-Jun N-terminal kinase (JNK), pro-caspase-3 and related mitochondrial apoptosis pathway induced by H2O2.	Water	159-163	mitogen-activated protein kinase 8	Homo sapiens	59-82
32295252-15	2020	This study is the first to show a direct effect of aldosterone to inhibit vasopressin-stimulated osmotic water permeability and urea permeability in perfused rat IMCDs.	Water	105-110	arginine vasopressin	Rattus norvegicus	74-85
32290408-4	2020	To this aim, dams were exposed, from one month pre-mating to offspring weaning, to Pb via drinking water at 5 mg/kg body weight per day.	Water	99-104	serine peptidase inhibitor, Kunitz type, 2	Rattus norvegicus	83-85
32290444-3	2020	The sensor was intended to detect the high latent heat of fusion of water (334 J/g) which is released to the environment during ice formation.	Water	68-73	carboxylesterase 2	Homo sapiens	128-131
32035614-5	2020	DFX also showed the inhibition effect on the activation of c-Jun N-terminal kinase (JNK), pro-caspase-3 and related mitochondrial apoptosis pathway induced by H2O2.	Water	159-163	mitogen-activated protein kinase 8	Homo sapiens	84-87
32035614-5	2020	DFX also showed the inhibition effect on the activation of c-Jun N-terminal kinase (JNK), pro-caspase-3 and related mitochondrial apoptosis pathway induced by H2O2.	Water	159-163	caspase 3	Homo sapiens	90-103
32608668-7	2020	The highest concentrations of acesulfame, saccharin, aspartame, and neotame in source water were 22.94, 39.17, 0.73, and 8.92 mug L-1, respectively, and detection rates were 72.7%, 90.9%, 18.2%, and 90.9%, respectively.	Water	86-91	L1 cell adhesion molecule	Homo sapiens	130-133
32186376-3	2020	Reverse micellar confinements were constructed by using model potentials mimicking AOT (charged) and IGEPAL (neutral) surfactant molecules for encapsulating SPC/E water.	Water	163-168	proline rich protein gene cluster	Homo sapiens	157-160
32351378-7	2020	Angiotensin II infusion did impair both wildtype and transgenic rats" executive functions in the Morris Water Maze.	Water	104-109	angiotensinogen	Rattus norvegicus	0-14
32176505-10	2020	The aim of this study was to investigate the properties of oleanolic acid in the presence of human serum albumin in terms of thermodynamics, morphology, and viscoelasticity at the air/water interface.	Water	184-189	albumin	Homo sapiens	99-112
32162913-8	2020	Lastly, we use our KH and KS results to discuss the aqueous processing of biomass-burning phenols in cloud/fog water versus aerosol liquid water.	Water	111-116	zinc finger protein, FOG family member 1	Homo sapiens	107-110
32268501-5	2020	Three experiments were conducted to examine the instrument performance: (i) to ensure light intensity of the LED bulbs is strong enough to pass through the water column; (ii) to determine the regression relationship between the measured light intensity of the instrument and Secchi depth; and (iii) to evaluate the coefficient of variation (CV) of the measured water clarity when using our instrument and a conventional Secchi disk.	Water	156-161	small integral membrane protein 10 like 2A	Homo sapiens	109-112
32242084-7	2020	Water efflux through aquaporin 1 and activation of protein kinase C via specific G protein-coupled receptors are essential to the pressure-induced transient activation of the Ras/ERK pathway.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	21-32
32242084-7	2020	Water efflux through aquaporin 1 and activation of protein kinase C via specific G protein-coupled receptors are essential to the pressure-induced transient activation of the Ras/ERK pathway.	Water	0-5	mitogen-activated protein kinase 1	Homo sapiens	179-182
32141290-4	2020	A mechanistic study suggests that the facile complexation of porphyrins with amphiphilic beta-CD via hydrogen bonding interaction greatly improves the water insolubility and the aggregation-caused deficient ECL of liposoluble porphyrins in aqueous solution.	Water	151-156	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	89-96
32095822-5	2020	The slac1 and ost1 mutants tended to keep their stomata open in fluctuating light, resulting in lower water-use efficiency (WUE) than the wild-type.	Water	102-107	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	4-9
32410829-4	2020	In this study, we investigated the effects of hot water extract derived from the tendrils of C. moschata Duchesne (TCMD) on NLRP3 inflammasome activation in murine macrophages and human trophoblast cells.	Water	50-55	NLR family pyrin domain containing 3	Homo sapiens	124-129
32260143-4	2020	An assessment of the expression levels of functional genes in the skin revealed that only the expression of the water channel aquaporin-3 (AQP3) was significantly decreased in the erlotinib-treated group.	Water	112-117	aquaporin 3	Mus musculus	139-143
32260143-7	2020	Dry skin due to erlotinib may be caused by the decreased expression of AQP3 in the skin, thereby limiting water transport from the vascular side to the corneum side.	Water	106-111	aquaporin 3	Mus musculus	71-75
32126545-4	2020	These resultant Col-Gd@Tub NCs with a diameter of 45 nm exhibited uniform particle size distribution and favorable stability without leakage of gadolinium in water.	Water	158-163	TUB bipartite transcription factor	Homo sapiens	23-26
32395484-11	2020	The functional interplay of cytochrome c (emitter) and COX (drain) with a nanoscopic interfacial water layer (gate) between the two enzymes forms a biological FET in which the gate is controlled by R-NIR photons.	Water	97-102	cytochrome c, somatic	Homo sapiens	28-40
32033950-0	2020	ESKAPE Bacteria and Extended-Spectrum-beta-Lactamase-Producing Escherichia coli Isolated from Wastewater and Process Water from German Poultry Slaughterhouses.	Water	117-122	EsbL	Escherichia coli	20-52
32088968-1	2020	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel protein responsible for osmotic water reabsorption by the kidney collecting ducts.	Water	46-51	arginine vasopressin	Homo sapiens	24-35
32088968-1	2020	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel protein responsible for osmotic water reabsorption by the kidney collecting ducts.	Water	92-97	arginine vasopressin	Homo sapiens	24-35
32088968-2	2020	In response to vasopressin, AQP2 traffics from intracellular vesicles to the apical plasma membrane of the collecting duct principal cells where it increases water permeability hence water reabsorption.	Water	158-163	arginine vasopressin	Homo sapiens	15-26
32088968-2	2020	In response to vasopressin, AQP2 traffics from intracellular vesicles to the apical plasma membrane of the collecting duct principal cells where it increases water permeability hence water reabsorption.	Water	183-188	arginine vasopressin	Homo sapiens	15-26
31917282-4	2020	TERRA increased in cells exposed to H2O2 and reverted by antioxidant treatment.	Water	36-40	doublesex and mab-3 related transcription factor 2	Mus musculus	0-5
31917282-9	2020	TERRA induction reverted within 2 h after removal of H2O2 from culture medium, suggesting they have protective functions.	Water	53-57	doublesex and mab-3 related transcription factor 2	Mus musculus	0-5
31917282-10	2020	This was supported by rapid TERRA induction following a second H2O2 challenge.	Water	63-67	doublesex and mab-3 related transcription factor 2	Mus musculus	28-33
31917282-11	2020	PKA inhibitors H89 and PKI blocked TERRA increase by H2O2 or IBMX+Forskolin treatment, suggesting PKA signaling regulates TERRA induction.	Water	53-57	doublesex and mab-3 related transcription factor 2	Mus musculus	35-40
31987853-8	2020	ARagonists were found to strongly bind to human serum albumin (HSA) and the protein components of lipoproteins - apolipoproteins; HSA was essential for the binding of water-soluble PSB0777, whereas apolipoproteins were needed for interactions with poorly-water soluble compounds such as UK432097 and MRE0094.	Water	167-172	albumin	Homo sapiens	48-61
31917282-11	2020	PKA inhibitors H89 and PKI blocked TERRA increase by H2O2 or IBMX+Forskolin treatment, suggesting PKA signaling regulates TERRA induction.	Water	53-57	doublesex and mab-3 related transcription factor 2	Mus musculus	122-127
31987853-8	2020	ARagonists were found to strongly bind to human serum albumin (HSA) and the protein components of lipoproteins - apolipoproteins; HSA was essential for the binding of water-soluble PSB0777, whereas apolipoproteins were needed for interactions with poorly-water soluble compounds such as UK432097 and MRE0094.	Water	255-260	albumin	Homo sapiens	48-61
32308262-9	2020	The involvement of W10 water center in theD3...W10...D4 recognition through Gln552...W10...His667 H-bond interaction is critical in the complexation of CP with myeloperoxidase(Mpo).	Water	23-28	myeloperoxidase	Homo sapiens	160-175
32120022-7	2020	The water-solubility of beta-CD-RH is up to 3.24 mumol/mL beta-CD-RH exhibited higher cytotoxicity than rhein and rhein/beta-CD mixture against Hela cells.	Water	4-9	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	24-31
31862296-2	2020	Its unique advantages for in vivo imaging and gene and drug screening have allowed the visualization of dual oxidase 1 (Duox1)-derived hydrogen peroxide (H2O2) tissue gradients and its crosstalk with neutrophil infiltration to inflamed tissue.	Water	154-158	dual oxidase	Danio rerio	104-118
31862296-2	2020	Its unique advantages for in vivo imaging and gene and drug screening have allowed the visualization of dual oxidase 1 (Duox1)-derived hydrogen peroxide (H2O2) tissue gradients and its crosstalk with neutrophil infiltration to inflamed tissue.	Water	154-158	dual oxidase	Danio rerio	120-125
31862296-5	2020	Finally, zebrafish models of psoriasis have shown that a H2O2/NF-kappaB/Duox1 positive feedback inflammatory loop operates in this chronic inflammatory disorder and that pharmacological inhibition of Duox1, but not of downstream mediators, inhibits inflammation and restores epithelial homeostasis.	Water	57-61	dual oxidase	Danio rerio	72-77
31983004-3	2020	The initial pH value significantly influenced on the degradation of p-ASA and at the optimal pH (3.0), p-ASA (10 mg L-1) could be completely oxidized to As(V), NH4+, and plentiful phenolic compounds such as phenol and p-hydroquinone via the cleavage of C-N and C-As bonds within 60 min in pure water.	Water	294-299	L1 cell adhesion molecule	Homo sapiens	116-119
32275070-5	2020	The content of immobile water (A22 ) and free water (A23 ) decreased (81.55% and 89.07%), whereas the bound water (A21 ) increased (7.26%).	Water	24-29	immunoglobulin kappa variable 3-25 (pseudogene)	Homo sapiens	31-34
32289134-0	2020	PURL: Can drinking more water prevent urinary tract infections?	Water	24-29	phosphoribosylformylglycinamidine synthase	Homo sapiens	0-4
31997111-1	2020	KEY MESSAGE: PTR2 in Arabidopsis thaliana is negatively regulated by ABI4 and plays a key role in water uptake by seeds, ensuring that imbibed seeds proceed to germination.	Water	98-103	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	69-73
31997111-10	2020	Taken together, the results suggest that ABI4-dependent temporal regulation of PTR2 expression may influence water status during seed germination to promote the post-germinative growth of imbibed seeds.	Water	109-114	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	41-45
32069384-3	2020	The active principles were not found in the soil and sediment samples, only the propoxur principle was found in the water, reaching values of up to 0.025 mug L-1 .	Water	116-121	immunoglobulin kappa variable 1-16	Homo sapiens	158-161
31190125-8	2020	Paired drinking water samples contained a median iodine concentration of 3.2 microg L-1 (0.2-304.1 microg L-1).	Water	16-21	immunoglobulin kappa variable 1-16	Homo sapiens	84-87
31917990-1	2020	A multi-functionalized poly ether sulfone (PES)/ chitosan (CS)/Fe3O4-NH2-SH nanofiber was applied for single and simultaneous removal of Pb(II) and Ni(II) ions from water systems.	Water	165-170	submaxillary gland androgen regulated protein 3B	Homo sapiens	137-143
32006712-7	2020	Treatment with CORM-3 and CORM-A1 (all concentrations from 0.1 to 100 muM) decreased thiol group oxidation induced by H2O2/Fe.	Water	118-122	latexin	Homo sapiens	70-73
32220772-1	2020	Cystic Fibrosis (CF) is a genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene which encodes for a chloride ion channel regulating the balance of salt and water across secretory epithelia.	Water	209-214	CF transmembrane conductance regulator	Homo sapiens	69-120
32220772-1	2020	Cystic Fibrosis (CF) is a genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene which encodes for a chloride ion channel regulating the balance of salt and water across secretory epithelia.	Water	209-214	CF transmembrane conductance regulator	Homo sapiens	122-126
31954344-7	2020	MIEX  resins were shown to be more effective to treat surface water than secondary effluent, including effective removal of DBP precursors with extended bed volume treatment.	Water	62-67	D-box binding PAR bZIP transcription factor	Homo sapiens	124-127
31954344-9	2020	Our results indicate that EEM-PARAFAC was valuable for assessing DBP formation potentials and removal of their precursors by MIEX  resins in different water sources.	Water	151-156	D-box binding PAR bZIP transcription factor	Homo sapiens	65-68
32308262-9	2020	The involvement of W10 water center in theD3...W10...D4 recognition through Gln552...W10...His667 H-bond interaction is critical in the complexation of CP with myeloperoxidase(Mpo).	Water	23-28	myeloperoxidase	Homo sapiens	176-179
32258491-4	2020	The strategy in the novel system of using mucin loading insulin into the inner core of prepared water in oil microemulsion to provide sustained released, increased in vivo stability and enhanced drug absorption in the gastrointestinal tract.	Water	96-101	insulin	Homo sapiens	56-63
32227478-1	2020	BACKGROUND: Cystic fibrosis is an autosomal recessive inherited defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in abnormal regulation of salt and water movement across the membranes.	Water	187-192	CF transmembrane conductance regulator	Homo sapiens	78-129
32227478-1	2020	BACKGROUND: Cystic fibrosis is an autosomal recessive inherited defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in abnormal regulation of salt and water movement across the membranes.	Water	187-192	CF transmembrane conductance regulator	Homo sapiens	131-135
32258491-5	2020	We report how microemulsion composed of varying ratios of snail mucin and Tween  80 (1:9-9:1) using oil/water emulsion preparation method influenced insulin performance after oral administration.	Water	104-109	insulin	Homo sapiens	149-156
32011145-6	2020	While trypsin binding is mediated by an ordered water molecule, in thrombin, water is scattered over three hydration sites.	Water	77-82	coagulation factor II, thrombin	Homo sapiens	67-75
32031808-5	2020	It also counteracted the cell cycle blockade induced by a low concentration of H2O2 decreasing the expression of p21 and CDKN2A (p16INK4A).	Water	79-83	cyclin dependent kinase inhibitor 2A	Homo sapiens	121-127
32031808-5	2020	It also counteracted the cell cycle blockade induced by a low concentration of H2O2 decreasing the expression of p21 and CDKN2A (p16INK4A).	Water	79-83	cyclin dependent kinase inhibitor 2A	Homo sapiens	129-137
32118448-4	2020	The packing structure of different PAM brushes were first determined and served as a structural basis for further exploring the CSL-dependent dynamics and structure of water molecules on PAM brushes and their surface resistance ability to lysozyme protein.	Water	168-173	chorionic somatomammotropin hormone like 1	Homo sapiens	128-131
32108483-7	2020	These predicted trends in the inherent deglycosylation energetics in water directly correlate with the previously reported activity of thymine DNA glycosylase (TDG), which cleaves the glycosidic bond in select dC nucleosides as part of epigenetic regulation and in dU variants as part of DNA repair.	Water	69-74	thymine DNA glycosylase	Homo sapiens	135-158
32108483-7	2020	These predicted trends in the inherent deglycosylation energetics in water directly correlate with the previously reported activity of thymine DNA glycosylase (TDG), which cleaves the glycosidic bond in select dC nucleosides as part of epigenetic regulation and in dU variants as part of DNA repair.	Water	69-74	thymine DNA glycosylase	Homo sapiens	160-163
32204690-15	2020	CONCLUSION: Hard water with high fluoride content resulted in acute tubular injury with a significant increase in serum levels of creatinine, urea and AST activity.	Water	17-22	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	151-154
32130011-1	2020	This study investigates the local structure and dynamics of hydration water around the intrinsically disordered protein amyloid-beta (Abeta) and its Alzheimer"s disease causative N-terminus mutants, i.e., A2V, Taiwan (D7H), Tottori (D7N), and English (H6R), and the protective A2T mutant via atomistic MD simulations.	Water	70-75	amyloid beta precursor protein	Homo sapiens	134-139
32130011-3	2020	The water density around the hydrophobic hp1 (17-21) domain is found to be higher for the A2T mutant as compared to the wild-type Abeta and its selected causative mutants.	Water	4-9	amyloid beta precursor protein	Homo sapiens	130-135
32078307-5	2020	In thrombin, water molecules are seemingly stable in the apo binding pocket and have an exchange rate on the nanosecond time-scale.	Water	13-18	coagulation factor II, thrombin	Homo sapiens	3-11
32213937-11	2020	The results show that embedding CNTs in the blended polymer (PSF/PES) increased both the porosity and water absorption capacity of the membranes, thereby resulting in enhanced water flux up to 309 L/m2h for 1.5 wt.	Water	102-107	insulin like growth factor binding protein 7	Homo sapiens	61-64
32213937-11	2020	The results show that embedding CNTs in the blended polymer (PSF/PES) increased both the porosity and water absorption capacity of the membranes, thereby resulting in enhanced water flux up to 309 L/m2h for 1.5 wt.	Water	176-181	insulin like growth factor binding protein 7	Homo sapiens	61-64
31960567-4	2020	Co/PMCS can eliminate O2 - and H2O2 by mimicking superoxide dismutase, catalase and glutathione peroxidase, while remove  OH via the oxidative-reduction cycle, exhibiting markedly higher activity than nanozymes.	Water	31-35	catalase	Mus musculus	71-79
32078307-7	2020	This difference in exchange rate is due to internal water channels that are only found in thrombin linking the interior of the binding pocket with bulk solvent.	Water	52-57	coagulation factor II, thrombin	Homo sapiens	90-98
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	280-283	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
32206077-7	2020	The rate of CLDs in the jejunal epithelium was increased in both trehalase KO and WT mice given water containing trehalose relative to untreated control mice.	Water	96-101	trehalase (brush-border membrane glycoprotein)	Mus musculus	65-74
32187230-6	2020	Renal GM3 levels were significantly higher in the nephritic MRL/lpr water-treated mice compared to non-nephritic MRL/MpJ mice, despite significantly increased renal NEU activity.	Water	68-73	Fas (TNF receptor superfamily member 6)	Mus musculus	64-67
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	298-301	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	298-301	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	298-301	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	298-301	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	298-301	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	298-301	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	298-301	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
31926226-5	2020	We found that in high-fat diet model, native carrageenan in drinking water increased the disease activity index (DAI), myeloperoxidase (MPO) activity and the mRNA expression of TLR4 in colon, whereas carrageenan-supplemented diet has no visible effects.	Water	69-74	toll-like receptor 4	Mus musculus	177-181
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	298-301	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	298-301	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	298-301	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
32188122-1	2020	A series of metal-organic coordination complexes based on alkaline-earth metal centers [Mg(II), Ca(II), and Ba(II)] and the ligand 5-aminoisophthalate (aip2-) revealed notable structural diversity, both in the materials" dimensionality and in their hydrogen bonding networks: [Mg(H2O)6] [Mg2(Haip)(H2O)10] (Haip) 3(aip) 10(H2O) (1) and [Mg(aip)(phen)(H2O)2] (H2O) (2) were isolated as discrete complexes (0D); [Ca(aip)(H2O)2] (H2O) (3), [Ca(aip)(phen)(H2O)2] (phen) (H2O) (4), and [Ba2(aip)2(phen)2(H2O)7] 2(phen) 2(H2O) (5) revealed metal-organic chain (1D) structures, while the [Ba(aip)(H2O)] (6) showed a metal-organic layered (2D) arrangement.	Water	298-301	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	152-156
32151055-5	2020	The outcomes demonstrate that the PVA hydrogel MRP prepared from precursor gel with water shows the highest MR effect of 15,544% among the PVA hydrogel MRPs.	Water	84-89	ATP binding cassette subfamily C member 1	Homo sapiens	47-50
31981628-12	2020	In addition, PHLDA1 binds to Bax and the interaction is enhanced under H2O2 stimulation.	Water	71-75	pleckstrin homology like domain family A member 1	Homo sapiens	13-19
31981628-12	2020	In addition, PHLDA1 binds to Bax and the interaction is enhanced under H2O2 stimulation.	Water	71-75	BCL2 associated X, apoptosis regulator	Homo sapiens	29-32
31881497-7	2020	The high [Formula: see text] observed in UV/SPC compensated for the smaller [Formula: see text] compared to [Formula: see text] and the consumption of HO  making the degradation rate of BPA in UV/SPC comparable to that in UV/H2O2.	Water	225-229	proline rich protein gene cluster	Homo sapiens	44-47
31948762-11	2020	Flow cytometry analysis of cells transfected by adenovirus with MIF-shRNA then exposed to H2O2 showed a significant decrease in cell death for MIF knockdown cells, even after AIF nuclear translocation.	Water	90-94	macrophage migration inhibitory factor	Rattus norvegicus	64-67
31948762-11	2020	Flow cytometry analysis of cells transfected by adenovirus with MIF-shRNA then exposed to H2O2 showed a significant decrease in cell death for MIF knockdown cells, even after AIF nuclear translocation.	Water	90-94	macrophage migration inhibitory factor	Rattus norvegicus	143-146
32178452-7	2020	The water secretion phase is triggered by an apical low volume-dependent factor opening the Cystic Fibrosis Transmembrane Regulator CFTR channel and secreting anions that are accompanied by paracellular sodium and water transport.	Water	4-9	CF transmembrane conductance regulator	Homo sapiens	132-136
32178452-7	2020	The water secretion phase is triggered by an apical low volume-dependent factor opening the Cystic Fibrosis Transmembrane Regulator CFTR channel and secreting anions that are accompanied by paracellular sodium and water transport.	Water	214-219	CF transmembrane conductance regulator	Homo sapiens	132-136
32036660-2	2020	AA simulations of a single histatin 5 peptide in water were used to obtain a structural ensemble, which is reweighted in a CGMC simulation in the presence of a negatively charged surface.	Water	49-54	histatin 3	Homo sapiens	27-37
32151055-2	2020	However, oxidation and desiccation in hydrogel MRP due to a large amount of water content as a dispersing phase would limit its usage for long-term applications, especially in industrial engineering.	Water	76-81	ATP binding cassette subfamily C member 1	Homo sapiens	47-50
32226906-0	2020	Food Additives (Hypochlorous Acid Water, Sodium Metabisulfite, and Sodium Sulfite) Strongly Affect the Chemical and Biological Properties of Vitamin B12 in Aqueous Solution.	Water	34-39	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	149-152
32226906-1	2020	Food additives, such as hypochlorous acid water, sodium metabisulfite, and sodium sulfite, strongly affect the chemical and biological properties of vitamin B12 (cyanocobalamin) in aqueous solution.	Water	42-47	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	157-160
32164386-4	2020	We found that subcutaneous injection of ASC-exosomes in an oxazolone-induced dermatitis model remarkably reduced trans-epidermal water loss, while enhancing stratum corneum (SC) hydration and markedly decreasing the levels of inflammatory cytokines such as IL-4, IL-5, IL-13, TNF-alpha, IFN-gamma, IL-17, and TSLP, all in a dose-dependent manner.	Water	129-134	PYD and CARD domain containing	Homo sapiens	40-43
32256194-7	2020	The increased interferon-gamma (IFN-gamma) in the aqueous humor of EAU participates in inducing DCreg to alleviate the symptom of EAU.	Water	67-70	interferon gamma	Mus musculus	14-30
32256194-7	2020	The increased interferon-gamma (IFN-gamma) in the aqueous humor of EAU participates in inducing DCreg to alleviate the symptom of EAU.	Water	67-70	interferon gamma	Mus musculus	32-41
32256194-7	2020	The increased interferon-gamma (IFN-gamma) in the aqueous humor of EAU participates in inducing DCreg to alleviate the symptom of EAU.	Water	130-133	interferon gamma	Mus musculus	14-30
32256194-7	2020	The increased interferon-gamma (IFN-gamma) in the aqueous humor of EAU participates in inducing DCreg to alleviate the symptom of EAU.	Water	130-133	interferon gamma	Mus musculus	32-41
32256194-11	2020	These DCreg induced by IFN-gamma might be used as a strategy to develop therapy for EAU management.	Water	84-87	interferon gamma	Mus musculus	23-32
32152269-5	2020	Molecular dynamics simulation infers that facet-dependent transferrin binding is also induced by the differential affinity of crystal facets to water molecules in the first solvation shell, which affects access to exposed facets.	Water	144-149	transferrin	Homo sapiens	58-69
32152284-4	2020	Results from our investigation indicate that DC in saline (EC > 1000 muS cm-1) water bodies (mean +- S.D, 297.13 +- 356.14 mg L-1, n = 186) are much higher than those in fresh water bodies (79.55 +- 199.34 mg L-1, n = 669).	Water	79-84	immunoglobulin kappa variable 1-16	Homo sapiens	126-129
32132065-0	2020	Metastatic Malignant Peripheral Nerve Sheath Tumor With NF1 Successfully Treated With "Gradual Subtraction" ICE Chemotherapy.	Water	108-111	neurofibromin 1	Homo sapiens	56-59
33480722-4	2020	Typically, both hydroxide and water diffusion constants decrease as the hydrophobic PPO block size increases.	Water	30-35	protoporphyrinogen oxidase	Homo sapiens	84-87
33480728-0	2020	Molecular dynamics simulations of amyloid-beta(16-22) peptide aggregation at air-water interfaces.	Water	81-86	amyloid beta precursor protein	Homo sapiens	34-46
33480728-1	2020	Oligomers of amyloid-beta (Abeta) peptides are known to be related to Alzheimer"s disease, and their formation is accelerated at hydrophilic-hydrophobic interfaces, such as the cell membrane surface and air-water interface.	Water	207-212	amyloid beta precursor protein	Homo sapiens	13-25
33480728-1	2020	Oligomers of amyloid-beta (Abeta) peptides are known to be related to Alzheimer"s disease, and their formation is accelerated at hydrophilic-hydrophobic interfaces, such as the cell membrane surface and air-water interface.	Water	207-212	amyloid beta precursor protein	Homo sapiens	27-32
31977219-1	2020	In this report, electrospray mass spectra for solutions of gramicidin S (G), ubiquitin (U), and cytochrome c (C) in H2O/CH3OH(1/1) were measured as a function of the high voltage (4000 V) pulse width in the range of 200 ns ~ 1 ms using a 4 mum i.d.	Water	116-119	cytochrome c, somatic	Homo sapiens	96-108
32121646-8	2020	Additionally, the collagen films obtained from chicken feet and swine showed water absorption, odors, and texture characteristics similar to commercial material, such as latex and celofane.	Water	77-82	collagen type III alpha 1 chain	Gallus gallus	18-26
32225705-1	2020	The influence of the initial polarization state of a source on the detection range of a system probing through natural dense water fog is analyzed.	Water	125-130	zinc finger protein, FOG family member 1	Homo sapiens	131-134
31302751-11	2020	Xenopus oocytes injected with AQP2-WT had increased osmotic water permeability when compared to AQP2-L137P, which correlated with lack of the mutant form in the plasma membrane.	Water	60-65	aquaporin 2 S homeolog	Xenopus laevis	30-34
31927233-3	2020	Herein, we develop a unique liposomal encapsulated catalase (CAT), lyso-targeted NIR photosensitizer (MBDP) and doxorubicin (Dox), forming FA-L@MD@CAT, to increase tumor oxygenation by catalyzing intratumoral high-expressed H2O2 for enhancing the combination of chemo-PDT.	Water	224-228	catalase	Homo sapiens	51-59
31927233-3	2020	Herein, we develop a unique liposomal encapsulated catalase (CAT), lyso-targeted NIR photosensitizer (MBDP) and doxorubicin (Dox), forming FA-L@MD@CAT, to increase tumor oxygenation by catalyzing intratumoral high-expressed H2O2 for enhancing the combination of chemo-PDT.	Water	224-228	catalase	Homo sapiens	61-64
32556016-8	2020	However, when analyzing the TSL, it was observed that Ca2+-MSNs, TiF4, and NaF were more effective in preventing dental erosion versus CPP-ACP, CPP-ACP/F-, and Milli-Q  water (p< 0.05).	Water	169-174	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
31734464-3	2020	METHODS: A combination of size-exclusion chromatography and water-catalyzed fluorescent emission was utilized to probe the structural features of metastable SOD1 nonnative trimers, the potential neurotoxic species in the fALS.	Water	60-65	superoxide dismutase 1	Homo sapiens	157-161
31734464-5	2020	The trimeric A4V SOD1 exhibits the least water molecules surrounding the W32, while I113T and the wild type appear to have more water molecules in the proximity of W32.	Water	41-46	superoxide dismutase 1	Homo sapiens	17-21
31734464-7	2020	CONCLUSIONS: Our studies unveil new insights into water-associated structural changes of SOD1 nonnative trimers and demonstrate that in situ incorporation of (2,6-aza)Trp is a sensitive and powerful tool for probing subtle changes of water environments during protein aggregation.	Water	50-55	superoxide dismutase 1	Homo sapiens	89-93
31734464-7	2020	CONCLUSIONS: Our studies unveil new insights into water-associated structural changes of SOD1 nonnative trimers and demonstrate that in situ incorporation of (2,6-aza)Trp is a sensitive and powerful tool for probing subtle changes of water environments during protein aggregation.	Water	234-239	superoxide dismutase 1	Homo sapiens	89-93
31734464-8	2020	GENERAL SIGNIFICANCE: The water-sensitive probe, (2,6-aza)Trp, demonstrates superior sensitivity for detecting modulation of water microsolvation, structural conformation during oligomer formation and 5FUrd binding to both wild type and mutant SOD1.	Water	26-31	superoxide dismutase 1	Homo sapiens	244-248
31734464-8	2020	GENERAL SIGNIFICANCE: The water-sensitive probe, (2,6-aza)Trp, demonstrates superior sensitivity for detecting modulation of water microsolvation, structural conformation during oligomer formation and 5FUrd binding to both wild type and mutant SOD1.	Water	125-130	superoxide dismutase 1	Homo sapiens	244-248
31302751-11	2020	Xenopus oocytes injected with AQP2-WT had increased osmotic water permeability when compared to AQP2-L137P, which correlated with lack of the mutant form in the plasma membrane.	Water	60-65	aquaporin 2 S homeolog	Xenopus laevis	30-35
31062242-4	2020	Water dissolved-phase SigmaPCB concentrations ranged from 150 to 170 pg L-1 with a median of 160 pg L-1, which is one-tenth of that measured in the 1990s.	Water	0-5	immunoglobulin kappa variable 1-16	Homo sapiens	72-75
31675454-9	2020	Moreover, the protective effect of Rapa on MSC senescence can be abolished by enhancing the level of ROS, and p38 inhibitor can reverse the promoting effect of H2 O2 on MSC senescence.	Water	160-165	mitogen-activated protein kinase 14	Homo sapiens	110-113
31062242-4	2020	Water dissolved-phase SigmaPCB concentrations ranged from 150 to 170 pg L-1 with a median of 160 pg L-1, which is one-tenth of that measured in the 1990s.	Water	0-5	immunoglobulin kappa variable 1-16	Homo sapiens	100-103
32047923-0	2020	Water amino acid-chelated trace mineral supplementation decreases circulating and intestinal HSP70 and proinflammatory cytokine gene expression in heat-stressed broiler chickens.	Water	0-5	heat shock protein family A (Hsp70) member 2	Gallus gallus	93-98
31935358-9	2020	While 50 muM H2O2 combined with 10 muM vorinostat showed 36.26% cytotoxicity on HCE cells during 24 h exposure, 50 muM tBHP with 10 muM vorinostat did not show cytotoxicity on HCE cells.	Water	13-17	latexin	Homo sapiens	9-12
31593329-1	2020	Catalase is a widespread heme-containing enzyme, which converts hydrogen peroxide (H2 O2 ) to water and molecular oxygen, thereby protecting cells from the toxic effects of H2 O2 .	Water	94-99	catalase	Homo sapiens	0-8
32049699-0	2020	Water Worries: Quick Review of PFAS Contamination as a Health Threat.	Water	0-5	phosphoribosylformylglycinamidine synthase	Homo sapiens	31-35
31739104-9	2020	Administration of CCl4 to rat severely depleted the activity level of catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD), and reduced glutathione (GSH) concentration while appreciably increased the concentration of thiobarbituric acid reactive substances (TBARS), H2O2, nitrite, TNF-alpha, IL-1beta and IL-2 in lung and kidney tissues of rat.	Water	277-281	C-C motif chemokine ligand 4	Rattus norvegicus	18-22
32036572-14	2020	Curcumin inhibits H2O2-induced increase of APP cleavage through beta-cleavage pathway and of intracellular Abeta production.	Water	18-22	amyloid beta precursor protein	Homo sapiens	107-112
31846437-8	2020	Treatment of netrin-1 inhibited H2O2 production derived from NADPH oxidase 4 (Nox4) through the UNC5b/cAMP/PKA signal pathway in AFs remodeling.	Water	32-36	unc-5 netrin receptor B	Rattus norvegicus	96-101
31841831-8	2020	The intraperitoneal mode was more effective than water drinking mode in reducing the levels of CAT, GPx, GSH, and SOD (P < 0.05).	Water	49-54	catalase	Rattus norvegicus	95-98
31932725-3	2020	We engineered LOXCAT, a fusion of bacterial lactate oxidase (LOX) and catalase (CAT), which irreversibly converts lactate and oxygen to pyruvate and water.	Water	149-154	catalase	Homo sapiens	70-78
31932725-3	2020	We engineered LOXCAT, a fusion of bacterial lactate oxidase (LOX) and catalase (CAT), which irreversibly converts lactate and oxygen to pyruvate and water.	Water	149-154	catalase	Homo sapiens	17-20
32066904-6	2020	Furthermore, water permeation through aquaporin-1 mediates the EV deformability, which further supports EV transport in hydrogels and a decellularized matrix.	Water	13-18	aquaporin 1 (Colton blood group)	Homo sapiens	38-49
31960265-5	2020	The data showed that Nec-1 (10-40 muM) attenuated the cell death induced by H2O2 in undifferentiated (UN-) and neuronal differentiated (RA-) SH-SY5Y cells with a higher efficacy in the former cell type.	Water	76-80	latexin	Homo sapiens	34-37
31846880-4	2020	The abundance of anions and cations in the lake water samples were in the following order of Cl- > HCO3- > SO42- > NO3- and Na+ > Mg2+ > Ca2+ > K+ respectively.	Water	48-53	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
31949029-11	2020	Our study reveals a regulatory role for the miR397b-LAC2 module in root lignification during water and phosphate deficiency.	Water	93-98	laccase 2	Arabidopsis thaliana	52-56
32005402-6	2020	Morphological and physiological differences related with the water loss were observed between leaves of OE- APA1 and WT plants.	Water	61-66	aspartic proteinase A1	Arabidopsis thaliana	108-112
31949029-0	2020	The MicroRNA397b -LACCASE2 Module Regulates Root Lignification under Water and Phosphate Deficiency.	Water	69-74	laccase 2	Arabidopsis thaliana	18-26
31949029-3	2020	We demonstrate here that LACCASE2 (LAC2) acts as a negative regulator of lignin deposition in root vascular tissues during water deficit.	Water	123-128	laccase 2	Arabidopsis thaliana	25-33
31949029-3	2020	We demonstrate here that LACCASE2 (LAC2) acts as a negative regulator of lignin deposition in root vascular tissues during water deficit.	Water	123-128	laccase 2	Arabidopsis thaliana	35-39
31949029-6	2020	LAC2 expression was significantly down-regulated under water deficit and posttranscriptionally regulated by microRNA397b (miR397b) in roots under normal and water-deficit conditions.	Water	55-60	laccase 2	Arabidopsis thaliana	0-4
31949029-6	2020	LAC2 expression was significantly down-regulated under water deficit and posttranscriptionally regulated by microRNA397b (miR397b) in roots under normal and water-deficit conditions.	Water	157-162	laccase 2	Arabidopsis thaliana	0-4
32376537-0	2020	[Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression].	Water	10-15	NFE2 like bZIP transcription factor 2	Homo sapiens	89-93
31866545-3	2020	We discovered that the complex 3 is unstable above 57  C in heavy water, while it is kinetically stable enough to be studied by NMR in detail at 1  C. We demonstrated the formation of a face-to-face 2:1 complex with a binding constant of approximately 2.2 x 106 M-2.	Water	66-71	Ras converting CAAX endopeptidase 1	Homo sapiens	194-200
32376537-5	2020	RESULTS: Compared with the PQ-exposed cells, the cells with hydrogen water treatment showed significantly lowered expressions of Col-I, Col-III, and alpha-SMA.	Water	69-74	actin alpha 1, skeletal muscle	Homo sapiens	149-158
32101556-2	2020	A peptide from C-terminus of interferon alpha1, conjugated to palmitoyl-lysine for cell penetration, denoted as IFNalpha-C, was tested for its anti-inflammatory properties in ARPE-19 cells, followed by testing in a mouse model of EAU.	Water	230-233	interferon alpha 1	Homo sapiens	29-46
32376537-6	2020	Interference of Nrf2 expression obviously attenuated the effect of hydrogen water on PQ-exposed cells.	Water	76-81	NFE2 like bZIP transcription factor 2	Homo sapiens	16-20
32376537-7	2020	Hydrogen water treatment significantly increased the expression of Nrf2 and promoted the production of the antioxidants in PQ-exposed lung fibroblasts.	Water	9-14	NFE2 like bZIP transcription factor 2	Homo sapiens	67-71
32376537-8	2020	CONCLUSIONS: Hydrogen water enhances Nrf2 expression to promote the proliferation and production of antioxidants and inhibit the differentiation and collagen secretion in PQ-exposed human lung fibroblasts in vitro.	Water	22-27	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
32053129-5	2020	Under the catalysis of acetylcholinesterase (AChE) and choline oxidase (CHO), H2O2 was produced by using acetylcholine chloride (ACh) as a substrate, which was sensitive to the proposed CL system.	Water	78-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	23-43
32053129-5	2020	Under the catalysis of acetylcholinesterase (AChE) and choline oxidase (CHO), H2O2 was produced by using acetylcholine chloride (ACh) as a substrate, which was sensitive to the proposed CL system.	Water	78-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-49
32043502-10	2020	In addition, the H2O2-induced injury in Nrf2-knockdown PC12 cells was more serious than it was in control cells, and CA-mediated neuroprotection was exclusively inhibited by the knock down of Nrf2 in PC12 cells.	Water	17-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	40-44
32043502-10	2020	In addition, the H2O2-induced injury in Nrf2-knockdown PC12 cells was more serious than it was in control cells, and CA-mediated neuroprotection was exclusively inhibited by the knock down of Nrf2 in PC12 cells.	Water	17-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	192-196
32101556-12	2020	Splenocytes isolated from mice with ongoing EAU exhibited antigen-specific T cell proliferation that was inhibited in the presence of IFNalpha-C.	Water	44-47	interferon alpha 10	Homo sapiens	134-144
32185191-9	2020	Using optimized agitation speed and dipping speed, coconut water was concentrated up to Brix 8.5  from the initial concentration of Brix 3.5 .	Water	59-64	biogenesis of ribosomes BRX1	Homo sapiens	88-92
31841921-7	2020	For the catchment as a whole, the average nitrate-N concentration (3.6 mg L-1) was slightly higher than the threshold of 2.5 mg L-1 nitrate-N in surface water.	Water	153-158	immunoglobulin kappa variable 1-16	Homo sapiens	128-131
32185191-9	2020	Using optimized agitation speed and dipping speed, coconut water was concentrated up to Brix 8.5  from the initial concentration of Brix 3.5 .	Water	59-64	biogenesis of ribosomes BRX1	Homo sapiens	132-136
31874248-6	2020	Cell-based studies showed that RUT significantly increased the LD50 for hydrogen peroxide (H2O2)-induced cell damage, activated NRF2 nuclear translocation, and suppressed the production of reactive oxygen species (ROS) in H2O2-treated HCT116 cells, activated NRF2 luciferase reporter activities in HCT116 cells and HepG2 cells, and induced the expression of NRF2 target genes in primary intestinal epithelial cells.	Water	222-226	NFE2 like bZIP transcription factor 2	Homo sapiens	259-263
32094383-0	2020	Direct solvent free synthesis of bare alpha-NiS, beta-NiS and alpha-beta-NiS composite as excellent electrocatalysts: Effect of self-capping on supercapacitance and overall water splitting activity.	Water	173-178	amyloid beta precursor protein	Homo sapiens	62-72
31874248-6	2020	Cell-based studies showed that RUT significantly increased the LD50 for hydrogen peroxide (H2O2)-induced cell damage, activated NRF2 nuclear translocation, and suppressed the production of reactive oxygen species (ROS) in H2O2-treated HCT116 cells, activated NRF2 luciferase reporter activities in HCT116 cells and HepG2 cells, and induced the expression of NRF2 target genes in primary intestinal epithelial cells.	Water	222-226	NFE2 like bZIP transcription factor 2	Homo sapiens	259-263
31877356-7	2020	Inhibition of catalase by 3-aminotriazole in hepatocytes resulted in the following effects: (i) increased peroxisomal H2O2 levels as measured by a peroxisome-targeted H2O2 probe (HyPer-P); (ii) elevated intracellular ROS; (iii) decreased peroxisomal biogenesis; (iv) activated ER stress; (v) induced lipogenic genes and neutral lipid accumulation; and (vi) suppressed insulin signaling cascade associated with JNK activation.	Water	118-122	catalase	Mus musculus	14-22
31877356-7	2020	Inhibition of catalase by 3-aminotriazole in hepatocytes resulted in the following effects: (i) increased peroxisomal H2O2 levels as measured by a peroxisome-targeted H2O2 probe (HyPer-P); (ii) elevated intracellular ROS; (iii) decreased peroxisomal biogenesis; (iv) activated ER stress; (v) induced lipogenic genes and neutral lipid accumulation; and (vi) suppressed insulin signaling cascade associated with JNK activation.	Water	167-171	catalase	Mus musculus	14-22
31891690-6	2020	In this study, we found that compound B stimulated transcriptional activity of Nrf2 in H2O2-treated SH-SY5Y cells by inhibiting its degradation through the ubiquitin-proteasome system.	Water	87-91	NFE2 like bZIP transcription factor 2	Homo sapiens	79-83
32093091-4	2020	High-performance liquid chromatography analysis of a CYP2E1 assay was developed on a reversed phase C18 column (SUPELCO 25 cm x 4.6 mm x 5 microm) at 282 nm using 60% H2O, 25% acetonitrile, and 15% methanol as mobile phase.	Water	167-170	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	53-59
32069316-1	2020	DO (HLA-DO, in human; murine H2-O) is a highly conserved nonclassical major histocompatibility complex class II (MHC II) accessory molecule mainly expressed in the thymic medulla and B cells.	Water	29-33	histocompatibility-2, MHC	Mus musculus	70-111
32069316-1	2020	DO (HLA-DO, in human; murine H2-O) is a highly conserved nonclassical major histocompatibility complex class II (MHC II) accessory molecule mainly expressed in the thymic medulla and B cells.	Water	29-33	histocompatibility-2, MHC	Mus musculus	113-119
32180974-10	2020	In vitro, the water residue showed the highest antioxidant capacity and angiotensin-converting enzyme (ACE) inhibitory activity, due to more reducing sugars and peptides.	Water	14-19	angiotensin I converting enzyme	Homo sapiens	103-106
31959388-6	2020	Water-insoluble TPEQH then precipitated and release fluorescence in situ, thereby successfully detecting the ALP.	Water	0-5	alkaline phosphatase, placental	Homo sapiens	109-112
32059723-0	2020	Chinese medicine Di-Huang-Yi-Zhi protects PC12 cells from H2O2-induced apoptosis by regulating ROS-ASK1-JNK/p38 MAPK signaling.	Water	58-62	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	99-103
31669938-6	2020	In the present study, we evaluated the use of several PC to prevent peroxidation of macromolecules and to elicit the activation of the Nrf2 transcription factor in H2O2-stresed IEC-6 enterocytic cell line.	Water	164-168	NFE2 like bZIP transcription factor 2	Rattus norvegicus	135-139
32059723-15	2020	In addition, DHYZ inhibited the phosphorylation of ASK1, JNK1/2/3 and p38 MAPK which were up-regulated by H2O2.	Water	106-110	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	51-55
32054506-4	2020	The associations between ERbeta and autophagy were detected in osteosarcoma U2-OS cells which were treated with E2, E2 + 2,3-Bis (4-hydroxyphenyl) propionitrile (DPN, ERbeta agonists), E2 + DPN + water, E2 + DPN + 3-Methyladenine (3-MA, autophagy inhibitor), respectively.	Water	196-201	estrogen receptor 1	Homo sapiens	25-31
32075095-1	2020	Reactions of NiCl2 6H2O and pyridin-2-one (C5H5NO = Hhp) afforded novel molecular complexes, i.e., mononuclear [NiCl2(Hhp)4] (1), dinuclear [NiCl2(Hhp)(H2O)2]2.2Hhp (3) and [Ni2Cl4(Hhp)5] 2MeCN (4), and an ionic complex [Ni(Hhp)6]Cl2 (2).	Water	20-23	IH	Homo sapiens	52-55
32075095-1	2020	Reactions of NiCl2 6H2O and pyridin-2-one (C5H5NO = Hhp) afforded novel molecular complexes, i.e., mononuclear [NiCl2(Hhp)4] (1), dinuclear [NiCl2(Hhp)(H2O)2]2.2Hhp (3) and [Ni2Cl4(Hhp)5] 2MeCN (4), and an ionic complex [Ni(Hhp)6]Cl2 (2).	Water	20-23	IH	Homo sapiens	118-121
32075095-1	2020	Reactions of NiCl2 6H2O and pyridin-2-one (C5H5NO = Hhp) afforded novel molecular complexes, i.e., mononuclear [NiCl2(Hhp)4] (1), dinuclear [NiCl2(Hhp)(H2O)2]2.2Hhp (3) and [Ni2Cl4(Hhp)5] 2MeCN (4), and an ionic complex [Ni(Hhp)6]Cl2 (2).	Water	20-23	IH	Homo sapiens	118-121
32075095-1	2020	Reactions of NiCl2 6H2O and pyridin-2-one (C5H5NO = Hhp) afforded novel molecular complexes, i.e., mononuclear [NiCl2(Hhp)4] (1), dinuclear [NiCl2(Hhp)(H2O)2]2.2Hhp (3) and [Ni2Cl4(Hhp)5] 2MeCN (4), and an ionic complex [Ni(Hhp)6]Cl2 (2).	Water	20-23	IH	Homo sapiens	118-121
32075095-1	2020	Reactions of NiCl2 6H2O and pyridin-2-one (C5H5NO = Hhp) afforded novel molecular complexes, i.e., mononuclear [NiCl2(Hhp)4] (1), dinuclear [NiCl2(Hhp)(H2O)2]2.2Hhp (3) and [Ni2Cl4(Hhp)5] 2MeCN (4), and an ionic complex [Ni(Hhp)6]Cl2 (2).	Water	20-23	IH	Homo sapiens	118-121
31995079-3	2020	A divide to conquer methodology considering a mixed homogeneous/inhomogeneous dielectric model and explicitly taking water molecules into account was employed to obtain a large set of uPA-uPAR residue-residue interaction energies.	Water	117-122	plasminogen activator, urokinase	Homo sapiens	184-187
32046059-1	2020	The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.	Water	178-183	gap junction protein, alpha 1	Mus musculus	83-94
31957427-2	2020	In particular, glass microfiber filters (Whatman GF/A) can be treated with low-concentration (20 mM) methyltrichlorosilane/toluene solution to be superhydrophobic (water contact angle >150 ) in less than 5 min; the modified glass microfiber filter can be readily patterned with UV/ozone irradiation to create hydrophilic reaction zones on the otherwise superhydrophobic substrate.	Water	164-169	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	49-53
32117119-4	2020	Instead, land use within the drainage basin could predict, to some extent, NO2 + NO3 concentrations in the water, which (together with temperature, chlorophyll a and total phosphorus) correlated to some extent with the water microbiome structure.	Water	107-112	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
32117119-4	2020	Instead, land use within the drainage basin could predict, to some extent, NO2 + NO3 concentrations in the water, which (together with temperature, chlorophyll a and total phosphorus) correlated to some extent with the water microbiome structure.	Water	219-224	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
31734497-14	2020	50% of the soil loss by water erosion originates from cropland (with a mean soil loss rate of 18.4 t ha-1 yr-1), which covers ca.	Water	24-29	Rho GTPase activating protein 45	Homo sapiens	101-110
31734497-16	2020	Model results showed that nearly 10% of the East Africa region is subject to moderate or elevated water erosion risks (>10 t ha-1 yr-1).	Water	98-103	Rho GTPase activating protein 45	Homo sapiens	125-134
31910972-3	2020	X-ray photoelectron spectroscopy (XPS) was employed to affirm the binding of the as-obtained CoIII-PPIX@Py2CD, whose electrochemical kinetics were extensively studied to validate the feasibility in the catalytic reduction of hydrogen peroxide (H2O2).	Water	244-248	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	93-98
32046059-1	2020	The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.	Water	178-183	gap junction protein, alpha 1	Mus musculus	96-100
32071881-8	2020	Conclusions: Catalase is a potent H2O2-scavenger even in acatalasemic mouse erythrocytes.	Water	34-38	catalase	Mus musculus	13-21
31896574-6	2020	We show that exposure to the oxidant H2O2 induced MMT1 expression, but not MMT2 expression, and identified the transcription factor Yap1 as being involved in oxidant-mediated MMT1 expression.	Water	37-41	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	132-136
32608712-6	2020	SO42-, NO3-, and NH4+ (SNA) were the dominant species of water-soluble ions in PM2.5 in Nanjing.	Water	57-62	NBL1, DAN family BMP antagonist	Homo sapiens	7-10
32608730-0	2020	[High-Frequency Dynamics of Water Quality and Phytoplankton Community in Inflowing River Mouth of Xin"anjiang Reservoir, China].	Water	28-33	xin actin binding repeat containing 1	Homo sapiens	98-101
31521632-7	2020	Overall, we conclude that AtPIP2;4, SoPIP2;1 and hAQP1 are all transporters of both H2O and H2O2, but have different efficiencies for various specificities.	Water	84-87	aquaporin 1 (Colton blood group)	Homo sapiens	49-54
31944654-7	2020	The millifluidic device decorated with CLEA of catalase has total activity of 660 U for degradation of H2O2, and it shows good stability under a flow rate of 200 microL/min.	Water	103-107	catalase	Homo sapiens	47-55
31377191-0	2020	Dipole-dipole interactions between tryptophan side chains and hydration water molecules dominate the observed dynamic stokes shift of lysozyme.	Water	72-77	lysozyme	Homo sapiens	134-142
31377191-4	2020	To interpret the relaxation, a molecular dynamics simulation of 75 ns was conducted for lysozyme immersed in a water box.	Water	111-116	lysozyme	Homo sapiens	88-96
31944654-3	2020	Catalase was chosen as a model enzyme to degrade H2O2 in wastewater samples.	Water	49-53	catalase	Homo sapiens	0-8
31895552-5	2020	Here we describe ssNMR measurements, performed on 2H,15N,13C-labeled FUS-LC fibrils, that provide new information about the interactions of hydroxyl-bearing residues with one another and with water.	Water	192-197	FUS RNA binding protein	Homo sapiens	69-72
31895552-7	2020	The data also reveal differences in hydrogen exchange rates with water for different side chain hydroxyl groups, providing information about solvent exposure and penetration of water into the FUS-LC fibril core.	Water	65-70	FUS RNA binding protein	Homo sapiens	192-195
31895552-7	2020	The data also reveal differences in hydrogen exchange rates with water for different side chain hydroxyl groups, providing information about solvent exposure and penetration of water into the FUS-LC fibril core.	Water	177-182	FUS RNA binding protein	Homo sapiens	192-195
32024207-0	2020	Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H2O2-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.	Water	58-62	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
32024207-8	2020	Taken together, our results show that curcumin could protect HTR8/SVneo cells from H2O2-induced oxidative stress by activating Nrf2 signaling pathway.	Water	83-87	NFE2 like bZIP transcription factor 2	Homo sapiens	127-131
31377191-8	2020	In addition, by inspecting the variation in dipole moments of the hydration water molecules around lysozyme, it was suggested that the observed relaxation could be attributed to the orientational relaxation of hydration water molecules participating in the hydrogen-bond network formed around each of the two tryptophan residues.	Water	76-81	lysozyme	Homo sapiens	99-107
31377191-8	2020	In addition, by inspecting the variation in dipole moments of the hydration water molecules around lysozyme, it was suggested that the observed relaxation could be attributed to the orientational relaxation of hydration water molecules participating in the hydrogen-bond network formed around each of the two tryptophan residues.	Water	220-225	lysozyme	Homo sapiens	99-107
31935365-4	2020	The results from cytotoxicity assays showed that AC had no significant effects in cell viability (P-value &lt; 0.0001), and exposure to H2O2 75 muM had a less toxic effect (P-value &lt; 0.05).	Water	136-140	latexin	Homo sapiens	144-147
31739109-4	2020	Upon the addition cell extract, the telomerase primer could extend and then hybridize with assistant DNA2 in the triple-helix, leading to the structure of triple-helix changes and release the hairpin DNA to hybridize with the capture DNA on the surface of Pt@P-MOF(Fe), resulting in the electrochemical signal readout of H2O2 reduction.	Water	321-325	DNA replication helicase/nuclease 2	Homo sapiens	101-105
31845282-0	2020	Facile in situ synthesis of cellulose microcrystalline-manganese dioxide nanocomposite for effective removal of Pb(II) and Cd(II) from water.	Water	135-140	submaxillary gland androgen regulated protein 3B	Homo sapiens	112-118
31566298-0	2020	Protective effects of galangin against H2 O2 -induced aging via the IGF-1 signaling pathway in human dermal fibroblasts.	Water	39-44	insulin like growth factor 1	Homo sapiens	68-73
31566298-6	2020	Furthermore, aging markers such as senescence-associated beta-galactosidase p53, p21Cip1/WAF1 , and p16INK4A were upregulated under H2 O2 exposure and galangin could reverse its effects.	Water	132-137	tumor protein p53	Homo sapiens	76-79
31566298-6	2020	Furthermore, aging markers such as senescence-associated beta-galactosidase p53, p21Cip1/WAF1 , and p16INK4A were upregulated under H2 O2 exposure and galangin could reverse its effects.	Water	132-137	cyclin dependent kinase inhibitor 1A	Homo sapiens	81-88
31566298-6	2020	Furthermore, aging markers such as senescence-associated beta-galactosidase p53, p21Cip1/WAF1 , and p16INK4A were upregulated under H2 O2 exposure and galangin could reverse its effects.	Water	132-137	cyclin dependent kinase inhibitor 1A	Homo sapiens	89-93
31566298-6	2020	Furthermore, aging markers such as senescence-associated beta-galactosidase p53, p21Cip1/WAF1 , and p16INK4A were upregulated under H2 O2 exposure and galangin could reverse its effects.	Water	132-137	cyclin dependent kinase inhibitor 2A	Homo sapiens	100-108
31612523-10	2020	Mechanism analysis indicated that morphine alleviated serum deprivation and H2 O2 -induced angiogenesis inhibition via reducing oxidative stress and damage, and activating Akt/mTOR/eIF4E signaling.	Water	76-81	AKT serine/threonine kinase 1	Homo sapiens	172-175
31612523-10	2020	Mechanism analysis indicated that morphine alleviated serum deprivation and H2 O2 -induced angiogenesis inhibition via reducing oxidative stress and damage, and activating Akt/mTOR/eIF4E signaling.	Water	76-81	mechanistic target of rapamycin kinase	Homo sapiens	176-180
31907700-0	2020	Silencing of soluble epoxide hydrolase 2 gene reduces H2O2-induced oxidative damage in rat intestinal epithelial IEC-6 cells via activating PI3K/Akt/GSK3beta signaling pathway.	Water	54-58	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
31907700-12	2020	We proved that siEPHX2 had a protective effect on H2O2-induced oxidative damage in IEC-6 cells through activating PI3K/Akt/GSK3beta signaling pathway.	Water	50-54	AKT serine/threonine kinase 1	Rattus norvegicus	119-122
31845282-9	2020	In addition, depth removal experiments show that the residual concentrations of Pb(II) and Cd(II) in natural water after adsorption are lower than 0.01 mg/L.	Water	109-114	submaxillary gland androgen regulated protein 3B	Homo sapiens	80-86
31848955-4	2020	The results showed that though there was more NO3- removed when W soil was prepared, the similar net nitrification rate in W soil to B soil and more than 20 mg N kg-1 water-soluble NO3- were observed in W soil, which indicated that the loss of NO3- would be enhanced.	Water	167-172	NBL1, DAN family BMP antagonist	Homo sapiens	181-184
31848955-4	2020	The results showed that though there was more NO3- removed when W soil was prepared, the similar net nitrification rate in W soil to B soil and more than 20 mg N kg-1 water-soluble NO3- were observed in W soil, which indicated that the loss of NO3- would be enhanced.	Water	167-172	NBL1, DAN family BMP antagonist	Homo sapiens	181-184
31617239-4	2020	Using enzyme-linked immunosorbent assay, the reactivities of autoantibody toward native, malondialdehyde (MDA) and hydrogen peroxide (H2 O2 ) modified CAT were evaluated in plasmas of patients and controls.	Water	134-139	catalase	Homo sapiens	151-154
31520921-1	2020	Protein conformation and the 3D water structure play important roles in the ability of bovine serum albumin (BSA) to form stable nanostructures with bioactive molecules.	Water	32-37	albumin	Homo sapiens	94-107
31816386-6	2020	In this study, we found that curcumin can effectively ameliorate hydrogen peroxide (H2O2)-induced oxidative stress, intestinal epithelial barrier injury and mitochondrial damage in porcine intestinal epithelial cells (IPEC-J2 cells) in a PTEN-induced putative kinase (PINK1)-Parkin mitophagy dependent way.	Water	84-88	PTEN induced kinase 1	Sus scrofa	268-273
31468277-8	2020	Enzyme-linked immunosorbent assay performed on day 7 revealed that hydrogen water reduced the level of the pro-inflammatory cytokine interleukin-6 and increased that of forkhead box P3 transcription factor, suggesting an enhancement of regulatory T cell activity.	Water	76-81	interleukin 6	Mus musculus	133-146
31894254-0	2020	Anti-platelet activity of mineral-balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk.	Water	52-57	AKT serine/threonine kinase 1	Homo sapiens	92-95
31894254-0	2020	Anti-platelet activity of mineral-balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk.	Water	52-57	mitogen-activated protein kinase 1	Homo sapiens	100-103
31614315-2	2020	Herein, a facile and general route is developed to prepare various non-noble metal-based electrocatalysts via NH3 H2O treatment (NT) on Ni foam (NF) (M-NT/NF, M = Co, Ni, Fe, Mn, Cu).	Water	110-117	MAX network transcriptional repressor	Homo sapiens	150-157
31616061-1	2020	Arginine vasopressin (AVP) and its type-2 receptor (V2R) play an essential role in the regulation of salt and water homeostasis by the kidneys.	Water	110-115	arginine vasopressin	Homo sapiens	9-20
31734539-2	2020	Lactoperoxidase is a hemoprotein that utilizes hydrogen peroxide (H2O2) and thiocyanate (SCN-) to produce hypothiocyanous acid (HOSCN), an antimicrobial agent also thought to be associated with carcinogenesis.	Water	66-70	lactoperoxidase	Homo sapiens	0-15
31734539-6	2020	Mesna inhibits LPO"s halogenation activity (IC50 value of 9.08 muM) by switching the reaction from a 2e- to a 1e- pathway, allowing the enzyme to function with significant peroxidase activity (conversion of H2O2 to H2O without generation of HOSCN).	Water	207-211	lactoperoxidase	Homo sapiens	15-18
31734539-6	2020	Mesna inhibits LPO"s halogenation activity (IC50 value of 9.08 muM) by switching the reaction from a 2e- to a 1e- pathway, allowing the enzyme to function with significant peroxidase activity (conversion of H2O2 to H2O without generation of HOSCN).	Water	207-210	lactoperoxidase	Homo sapiens	15-18
31887554-5	2020	One- and two-dimensional 13C ssNMR measurements at 25 K on the complex of the 27-residue peptide M13 with the calcium-sensing protein calmodulin, in glycerol/water with 10 mM succinyl-DOTOPA, demonstrate the utility of this compound in DNP-enhanced ssNMR studies of biomolecular systems.	Water	158-163	calmodulin 1	Homo sapiens	134-144
31711999-5	2020	The hydrophilicity and water-containing capacity of core-shell nanofibrous insulin/PLGA scaffolds significantly exceeded those of blended nanofibrous scaffolds.	Water	23-28	insulin	Homo sapiens	75-82
31616061-1	2020	Arginine vasopressin (AVP) and its type-2 receptor (V2R) play an essential role in the regulation of salt and water homeostasis by the kidneys.	Water	110-115	arginine vasopressin receptor 2	Homo sapiens	52-55
32082162-2	2019	Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3beta/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes.	Water	0-5	insulin	Homo sapiens	44-51
32237498-6	2020	The results showed that the water extract of C. crocea significantly decreased the number of WBC, NE, EO, increased the number of BA and LY, decreased the levels of TNF-alpha, IL-1beta, IL-6 and the expression of p65 and p-IkappaBalpha protein in NF-kappaB signaling pathway, and effectively alleviated the inflammatory symptoms.	Water	28-33	tumor necrosis factor	Rattus norvegicus	165-174
32237498-6	2020	The results showed that the water extract of C. crocea significantly decreased the number of WBC, NE, EO, increased the number of BA and LY, decreased the levels of TNF-alpha, IL-1beta, IL-6 and the expression of p65 and p-IkappaBalpha protein in NF-kappaB signaling pathway, and effectively alleviated the inflammatory symptoms.	Water	28-33	interleukin 1 alpha	Rattus norvegicus	176-184
32237498-6	2020	The results showed that the water extract of C. crocea significantly decreased the number of WBC, NE, EO, increased the number of BA and LY, decreased the levels of TNF-alpha, IL-1beta, IL-6 and the expression of p65 and p-IkappaBalpha protein in NF-kappaB signaling pathway, and effectively alleviated the inflammatory symptoms.	Water	28-33	interleukin 6	Rattus norvegicus	186-190
32237498-6	2020	The results showed that the water extract of C. crocea significantly decreased the number of WBC, NE, EO, increased the number of BA and LY, decreased the levels of TNF-alpha, IL-1beta, IL-6 and the expression of p65 and p-IkappaBalpha protein in NF-kappaB signaling pathway, and effectively alleviated the inflammatory symptoms.	Water	28-33	synaptotagmin 1	Rattus norvegicus	213-216
31646648-9	2020	CONCLUSION: The results of the study revealed that adulterated egg samples (with water) could be qualitatively detected using ATR-FTIR and NIR spectroscopy techniques in combination with PCA.	Water	81-86	ATR serine/threonine kinase	Homo sapiens	126-129
32082162-2	2019	Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3beta/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes.	Water	0-5	forkhead box O1	Homo sapiens	91-96
31825424-5	2020	They also showed anti-inflammatory potential in tumor necrosis factor (TNF)-alpha-, interleukin (IL)-1beta- and H2O2-stimulated Caco-2 cells by suppressing the secretion of IL-8 and the expression of cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS).	Water	112-116	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
31825424-5	2020	They also showed anti-inflammatory potential in tumor necrosis factor (TNF)-alpha-, interleukin (IL)-1beta- and H2O2-stimulated Caco-2 cells by suppressing the secretion of IL-8 and the expression of cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS).	Water	112-116	prostaglandin-endoperoxide synthase 2	Homo sapiens	200-216
31825424-5	2020	They also showed anti-inflammatory potential in tumor necrosis factor (TNF)-alpha-, interleukin (IL)-1beta- and H2O2-stimulated Caco-2 cells by suppressing the secretion of IL-8 and the expression of cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS).	Water	112-116	prostaglandin-endoperoxide synthase 2	Homo sapiens	218-223
31825424-5	2020	They also showed anti-inflammatory potential in tumor necrosis factor (TNF)-alpha-, interleukin (IL)-1beta- and H2O2-stimulated Caco-2 cells by suppressing the secretion of IL-8 and the expression of cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS).	Water	112-116	nitric oxide synthase 2	Homo sapiens	229-260
31825424-5	2020	They also showed anti-inflammatory potential in tumor necrosis factor (TNF)-alpha-, interleukin (IL)-1beta- and H2O2-stimulated Caco-2 cells by suppressing the secretion of IL-8 and the expression of cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS).	Water	112-116	nitric oxide synthase 2	Homo sapiens	262-266
31927927-4	2020	The [MnH(PCA2-EA)] complex displays a relatively slow water exchange rate ((4.0 +- 0.2) x 107 s-1), but the pH-dependent coordination of the ethylamine moiety occurs in the pH range of 6-8 (log KMnLH = 6.88), enabling the complex to exhibit pH-sensitive relaxivity in the biologically relevant pH range.	Water	54-59	prostate cancer associated transcript 2	Homo sapiens	9-13
31774423-5	2020	The conductivity of [2-Sema][TfO] exponentially increases depending on the H2O concentration.	Water	75-78	semaphorin 3B	Homo sapiens	23-27
31880441-4	2020	Specifically, the MoO3-x NUs first induce catalase (CAT)-like reactivity to decompose hydrogen peroxide (H2O2) in tumor microenvironment, producing a considerable amount of O2 for subsequent oxidase (OXD)-like reactivity of MoO3-x NUs; a substantial cytotoxic superoxide radical ( O2-) is thus generated for tumor cell apoptosis.	Water	105-109	catalase	Homo sapiens	42-50
31880441-4	2020	Specifically, the MoO3-x NUs first induce catalase (CAT)-like reactivity to decompose hydrogen peroxide (H2O2) in tumor microenvironment, producing a considerable amount of O2 for subsequent oxidase (OXD)-like reactivity of MoO3-x NUs; a substantial cytotoxic superoxide radical ( O2-) is thus generated for tumor cell apoptosis.	Water	105-109	catalase	Homo sapiens	52-55
31962290-3	2020	The lines differed considerably in sensitivity to H2O2 (IC50 of 528 and 33.5 muM, respectively).	Water	50-54	latexin	Homo sapiens	77-80
31973719-9	2020	IL-24 treatment reduced the number of apoptotic cells (0.5x, p &lt; 0.05) and decreased the expression of inflammatory factors, including IL1A, IL6 and TNF of H2O2-treated FHs74Int cells.	Water	159-163	interleukin 6	Homo sapiens	144-147
31973719-9	2020	IL-24 treatment reduced the number of apoptotic cells (0.5x, p &lt; 0.05) and decreased the expression of inflammatory factors, including IL1A, IL6 and TNF of H2O2-treated FHs74Int cells.	Water	159-163	tumor necrosis factor	Homo sapiens	152-155
31993073-16	2020	Conclusion: 13-MB exerts cytoprotective effects in an H2O2-induced cell injury model by inhibiting NLRP3 inflammasome activation via autophagy induction in HUVECs.	Water	54-58	NLR family pyrin domain containing 3	Homo sapiens	99-104
31774423-6	2020	The results from 1H-NMR spectroscopy and self-diffusion coefficient measurements by 1H field-gradient NMR indicate a fast proton exchange process between [2-Sema]+ and H2O.	Water	168-171	semaphorin 3B	Homo sapiens	157-161
31959115-0	2020	Differential expression of IDA (INFLORESCENCE DEFICIENT IN ABSCISSION)-like genes in Nicotiana benthamiana during corolla abscission, stem growth and water stress.	Water	150-155	Putative membrane lipoprotein	Arabidopsis thaliana	32-69
31961007-10	2020	However, overexpression of circHIPK3 attenuated cell damage caused by H2 O2 that it increased cell viability, decreased apoptosis, autophagy and MFI through upregulating miR-455.	Water	70-75	microRNA 455	Rattus norvegicus	170-177
31961007-12	2020	Our study demonstrated that circHIPK3 attenuated H2 O2 -induced cell damage and activated Nrf2 and ERK signal pathways by upregulation of miR-455.	Water	49-54	microRNA 455	Rattus norvegicus	138-145
31773880-2	2020	The H3L triangulene contains three phosphinate groups and an extended pi-conjugated framework, which enables the stimuli-responsive reversible transformation of [Cu(HL)(DMSO) (MeOH)]n, a 3D-MOF that exhibits reversible sorption characteristics, into (H3L 0.5[Cu2(OH)4 6H2O] 4H2O), a 1D-columnar assembled proton-conducting material.	Water	257-278	H3 clustered histone 2	Homo sapiens	4-7
31773880-2	2020	The H3L triangulene contains three phosphinate groups and an extended pi-conjugated framework, which enables the stimuli-responsive reversible transformation of [Cu(HL)(DMSO) (MeOH)]n, a 3D-MOF that exhibits reversible sorption characteristics, into (H3L 0.5[Cu2(OH)4 6H2O] 4H2O), a 1D-columnar assembled proton-conducting material.	Water	257-278	H3 clustered histone 2	Homo sapiens	251-254
32218969-1	2020	A novel hydrophobic and cationic cyclodextrin-based acrylamide flocculant (AM-beta-CD-DMDAAC) was prepared by chemical oxidative polymerization to adsorb water-soluble dyes in dye wastewater.	Water	154-159	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-85
31849213-6	2020	Catalase (CAT) was encapsulated to catalyze the production of oxygen (O2) from H2O2.	Water	79-83	catalase	Mus musculus	0-8
31963747-6	2020	In the present study, we demonstrated that NZ-419 eliminated reactive oxygen species production in HCT116 cells after H2O2 stimulation and suppressed H2O2-induced Nrf2 promoter transcriptional activity.	Water	150-154	NFE2 like bZIP transcription factor 2	Homo sapiens	163-167
31963256-1	2020	Catalase (CAT) stands out as one of the most efficient natural enzymes when catalysing the split of H2O2 into H2O and O2; H2O2 is one of the reactive oxygen species (ROS) involved in oxidative stress, a process closely related to aging and several health disorders or diseases like male infertility.	Water	100-104	catalase	Homo sapiens	0-8
31963256-1	2020	Catalase (CAT) stands out as one of the most efficient natural enzymes when catalysing the split of H2O2 into H2O and O2; H2O2 is one of the reactive oxygen species (ROS) involved in oxidative stress, a process closely related to aging and several health disorders or diseases like male infertility.	Water	100-104	catalase	Homo sapiens	10-13
31963256-1	2020	Catalase (CAT) stands out as one of the most efficient natural enzymes when catalysing the split of H2O2 into H2O and O2; H2O2 is one of the reactive oxygen species (ROS) involved in oxidative stress, a process closely related to aging and several health disorders or diseases like male infertility.	Water	100-103	catalase	Homo sapiens	0-8
31963256-1	2020	Catalase (CAT) stands out as one of the most efficient natural enzymes when catalysing the split of H2O2 into H2O and O2; H2O2 is one of the reactive oxygen species (ROS) involved in oxidative stress, a process closely related to aging and several health disorders or diseases like male infertility.	Water	100-103	catalase	Homo sapiens	10-13
31963256-1	2020	Catalase (CAT) stands out as one of the most efficient natural enzymes when catalysing the split of H2O2 into H2O and O2; H2O2 is one of the reactive oxygen species (ROS) involved in oxidative stress, a process closely related to aging and several health disorders or diseases like male infertility.	Water	122-126	catalase	Homo sapiens	0-8
31963256-1	2020	Catalase (CAT) stands out as one of the most efficient natural enzymes when catalysing the split of H2O2 into H2O and O2; H2O2 is one of the reactive oxygen species (ROS) involved in oxidative stress, a process closely related to aging and several health disorders or diseases like male infertility.	Water	122-126	catalase	Homo sapiens	10-13
31963866-10	2020	Delphinidin can protect chondrocytes against H2O2-induced apoptosis via activation of Nrf2 and NF-kappaB and protective autophagy.	Water	45-49	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
31963866-10	2020	Delphinidin can protect chondrocytes against H2O2-induced apoptosis via activation of Nrf2 and NF-kappaB and protective autophagy.	Water	45-49	nuclear factor kappa B subunit 1	Homo sapiens	95-104
31849213-6	2020	Catalase (CAT) was encapsulated to catalyze the production of oxygen (O2) from H2O2.	Water	79-83	catalase	Mus musculus	10-13
31873002-5	2020	More importantly, the CAT-mimicking Pt nanozyme on the Sm-TCPP nanosheets could effectively convert over-expressed H2O2 in the tumor microenvironment into O2 to relieve tumor hypoxia.	Water	115-119	catalase	Homo sapiens	22-25
31726076-4	2020	We hypothesized that a particle designed to discharge thrombin cargos in response to an external stimulus, such as H2O2, would provide control of the gelation rate over a broad range while strengthening the gel.	Water	115-119	coagulation factor II, thrombin	Homo sapiens	54-62
32009986-7	2019	Results: Edaravone significantly inhibited the reduction of the viability as well as upregulation of TNF-alpha expression by treatment with H2O2.	Water	140-144	tumor necrosis factor	Mus musculus	101-110
31940823-3	2020	We aimed to evaluate the PI3K/AKT/FoxO3a pathway as a mechanism of cell survival in lung epithelial A549 cells exposed to PM10 that were subsequently challenged with hydrogen peroxide (H2O2).	Water	185-189	forkhead box O3	Homo sapiens	34-40
31726076-5	2020	We examined this hypothesis by assembling poly (lactic-co-glycolic acid) (PLGA) particles loaded with thrombin and MnO2 nanosheets that decompose H2O2 to O2 gas.	Water	146-150	coagulation factor II, thrombin	Homo sapiens	102-110
31829553-3	2020	As expected, such a binder-free, 3D hierarchical structure PRP electrode presented a high catalytic property, good stability as well as low activation energy towards H2O2 electroreduction during the electrochemical measurement period.	Water	166-170	complement component 4 binding protein alpha	Homo sapiens	59-62
31917826-8	2020	We show that pbo-1 mutants exhibited decreased H2O2 in response to pathogens, which could also be partially restored in pbo-1 animals treated with bicarbonate.	Water	47-51	Uncharacterized protein	Caenorhabditis elegans	13-18
31829553-4	2020	The PRP electrode showed a reduction current density of 810 mA cm-2 at -0.2 V (vs. Ag/AgCl) in 2.0 mol L-1 H2SO4 and 2.0 mol L-1 H2O2.	Water	129-133	complement component 4 binding protein alpha	Homo sapiens	4-7
31829553-7	2020	Also, the activation energy of H2O2 electroreduction on 3D PRP electrode was 21.624 kJ mol-1.	Water	31-35	complement component 4 binding protein alpha	Homo sapiens	59-62
31810655-6	2020	FPOP coupled with native ion mobility separation shows that exposure to H2O2 results in the accumulation of a compact state of cyt c.	Water	72-76	cytochrome c, somatic	Homo sapiens	127-132
31822063-0	2020	pH-Neutralization, Redox-Balanced Process with Coupled Formate Dehydrogenase and Glucose Dehydrogenase Supports Efficient Xylitol Production in Pure Water.	Water	149-154	aldehyde dehydrogenase 1 family member L1	Homo sapiens	55-76
33997172-3	2021	The expression of AQP-1, -3, -4, -5, -8 and -9 were found in the digestive system, where these six AQP isoforms serve essential roles including mediating the transmembrane water transport and regulating the secretion of gastrointestinal (GI) fluids, consequently facilitating the digestion and absorption of GI contents.	Water	172-177	aquaporin 1 (Colton blood group)	Homo sapiens	18-46
31740907-1	2020	Rhenium(i) di- and tri-carbonyl complexes of the form fac-[Re(CO)3(L,L"-Bid)X] and [Re(CO)2(L,L"-Bid)X2], where X = aqua (H2O), methanol (CH3OH), triphenylphosphine (PPh3), 1,3,5-triaza-7-phosphaadamantane (PTA), tricyclohexylphosphine (PCy3) and L,L"-Bid = O,O" bidentate ligands (tropolone = TropH and 3-hydroxyflavone = FlavH) and N,O bidentate ligands (8-hydroxyquinoline = QuinH, 5,7-chloro-8-hydroxyquinoline = diCl-QuinH and quinoline-2,4-dicarboxylic acid = QuinH2), were synthesized and unambiguously characterized by 1H-, 13C-and 31P-NMR, IR, UV/Vis and micro-analysis.	Water	122-125	FA complementation group C	Homo sapiens	54-57
31984281-4	2020	On the basis of extended conjugation and planarity, L 1 complexes exhibited superior bioactivity with greater calculated DNA binding constant values, (K b) 2.9444 x 103 [(L 1 ) 2 Cu] and 2.2693 x 103 [(L 1 ) 2 Zn], as compared to L 2 complexes, 1.793 x 103 [(L 2 )Cu(H 2 O)] and 9.801 x 102 [(L 2 )Zn(H 2 O)].	Water	267-272	L1 cell adhesion molecule	Homo sapiens	52-55
31984281-4	2020	On the basis of extended conjugation and planarity, L 1 complexes exhibited superior bioactivity with greater calculated DNA binding constant values, (K b) 2.9444 x 103 [(L 1 ) 2 Cu] and 2.2693 x 103 [(L 1 ) 2 Zn], as compared to L 2 complexes, 1.793 x 103 [(L 2 )Cu(H 2 O)] and 9.801 x 102 [(L 2 )Zn(H 2 O)].	Water	301-306	L1 cell adhesion molecule	Homo sapiens	52-55
31150554-4	2020	At test, during CS presentations, DN-DISC1-PrP mice consumed more water and displayed a licking profile that is more typically revealed while ingesting a sweet-tasting solution.	Water	66-71	proline rich protein HaeIII subfamily 1	Mus musculus	43-46
31374372-5	2020	The efficiency of the synthesized biocomposite for Pb(II) and Cd(II) removal from water was studied via laboratory scale experiments.	Water	82-87	submaxillary gland androgen regulated protein 3B	Homo sapiens	51-57
31705858-11	2020	We also found that silencing NRF2, using RNA interference, reduced the protective effects of PD against H2O2-induced oxidative stress in orbital fibroblasts in vitro.	Water	104-108	nuclear factor, erythroid derived 2, like 2	Mus musculus	29-33
31948064-0	2020	Bovine Serum Albumin Protein-Based Liquid Crystal Biosensors for Optical Detection of Toxic Heavy Metals in Water.	Water	108-113	albumin	Homo sapiens	7-20
31150554-5	2020	DN-DISC1-PrP mice also displayed greater c-fos expression in the insular (gustatory) cortex when consuming water in the presence of the CS.	Water	107-112	proline rich protein HaeIII subfamily 1	Mus musculus	9-12
31188544-3	2020	Claudin-2, but not claudin-10b, also forms water channels.	Water	43-48	claudin 2	Canis lupus familiaris	0-9
31188544-15	2020	CONCLUSION: Claudin-15, similar to claudin-2, forms a paracellular cation and water channel.	Water	78-83	claudin 2	Canis lupus familiaris	35-44
31793717-4	2020	This reaction simultaneously produces abundant H2 O2 to induce cell death and damage the structure of transferrin to release Fe3+ , which will react with H2 O2 to produce highly toxic  OH to kill tumor cells.	Water	47-52	transferrin	Homo sapiens	102-113
32477601-4	2020	In the kidneys of non-anesthetized rats, which received a water load of 2 ml per 100 g of body weight, three effects of vasopressin were revealed: 1) increased reabsorption of water and sodium, 2) increased excretion of potassium ions, and 3) increased excretion of sodium ions.	Water	58-63	arginine vasopressin	Rattus norvegicus	120-131
32477601-4	2020	In the kidneys of non-anesthetized rats, which received a water load of 2 ml per 100 g of body weight, three effects of vasopressin were revealed: 1) increased reabsorption of water and sodium, 2) increased excretion of potassium ions, and 3) increased excretion of sodium ions.	Water	176-181	arginine vasopressin	Rattus norvegicus	120-131
31793717-4	2020	This reaction simultaneously produces abundant H2 O2 to induce cell death and damage the structure of transferrin to release Fe3+ , which will react with H2 O2 to produce highly toxic  OH to kill tumor cells.	Water	154-159	transferrin	Homo sapiens	102-113
31676353-1	2020	Water influx through aquaporin-1 (AQP-1) has been linked to the ability of different cell types to migrate, and therefore plays an important part in processes like metastasis and angiogenesis.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	21-32
31631450-8	2020	Next, it reviews existing evidence of how maternal water restriction in utero and during lactation shape vasopressin release, thirst thresholds, drinking patterns, and body water homeostasis for the infant.	Water	51-56	arginine vasopressin	Homo sapiens	105-116
31682170-2	2020	In human kidneys, nine aquaporins (AQPs), including AQP1-8 and AQP11, have been found and are differentially expressed along the renal tubules and collecting ducts with distinct and critical roles in the regulation of body water homeostasis and urine concentration.	Water	223-228	aquaporin 1 (Colton blood group)	Homo sapiens	52-58
31682170-2	2020	In human kidneys, nine aquaporins (AQPs), including AQP1-8 and AQP11, have been found and are differentially expressed along the renal tubules and collecting ducts with distinct and critical roles in the regulation of body water homeostasis and urine concentration.	Water	223-228	aquaporin 11	Homo sapiens	63-68
31368879-4	2020	RESULTS: New water soluble derivatives showed a micromolar cytotoxicity for cultured human tumor cell lines in the dark, including the subline with an altered drug response due to p53 inactivation.	Water	13-18	tumor protein p53	Homo sapiens	180-183
31407065-7	2020	We assessed neurological scores and brain water content at 24 h. The administration of a galectin-3 inhibitor significantly ameliorated brain edema and neuronal score in experimental SAH mice.	Water	42-47	lectin, galactose binding, soluble 3	Mus musculus	89-99
31676353-1	2020	Water influx through aquaporin-1 (AQP-1) has been linked to the ability of different cell types to migrate, and therefore plays an important part in processes like metastasis and angiogenesis.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	34-39
31499309-5	2020	Complete degradation of phenol (of initial concentration 50 mg L-1) was achieved under the near-optimum operating conditions (40 mA cm-2, pH 7, 0.4 m3 h-1 water circulation rate) within 30 min.	Water	155-160	L1 cell adhesion molecule	Homo sapiens	63-66
31810119-13	2020	Additionally, FLJC protected against H2O2-induced apoptosis by inhibiting changes in expression of major Bcl-2 family effector proteins of the mitochondrial apoptosis pathway.	Water	37-41	B cell leukemia/lymphoma 2	Mus musculus	105-110
31810119-14	2020	Furthermore, FLJC protected cells from H2O2-induced oxidative damage by up-regulating Nrf2 and HO-1 protein levels.	Water	39-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
31810119-14	2020	Furthermore, FLJC protected cells from H2O2-induced oxidative damage by up-regulating Nrf2 and HO-1 protein levels.	Water	39-43	heme oxygenase 1	Mus musculus	95-99
31520978-4	2020	About 35% of the drinking water samples showed radon concentrations above the European Union"s parametric value of 100 Bq l-1.	Water	26-31	immunoglobulin kappa variable 1-16	Homo sapiens	122-125
31524614-4	2020	The arsenic concentration of the water spring was 1481.9 mug L-1, and as the distance from the water spring increased, the arsenic concentration in the overlying water, pore-water and surface sediments decreased.	Water	33-38	immunoglobulin kappa variable 1-16	Homo sapiens	61-64
32009081-4	2020	Significant c-Met kinase activity was observed in 30, 40, and 50% methanol (MeOH) eluate fractions obtained from water extract of EHE using Diaion HP-20 column chromatography.	Water	113-118	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	12-17
31237219-5	2020	RESULTS: Angiotensin II (ANG II), beside stimulating aldosterone, vasopressin and CRH-ACTH release, sodium and water retention, thirst, and sympathetic nerve activity, exerts its effects on the immune system via the Angiotensin Type 1 Receptor (AT 1R) that is located in the brain, pituitary adrenal gland, and kidney.	Water	111-116	angiotensinogen	Homo sapiens	9-23
32072894-8	2020	Interestingly, in addition to some specific structural perturbations mediated by Asp1116 on the dynamics of CBP, our study revealed that the strong hydrogen bond interaction (N-H O) elicited in CBP-Y08197 sequestered Y08197 tightly into the CBP bromodomain active site.	Water	175-180	CREB binding protein	Homo sapiens	108-111
32072894-8	2020	Interestingly, in addition to some specific structural perturbations mediated by Asp1116 on the dynamics of CBP, our study revealed that the strong hydrogen bond interaction (N-H O) elicited in CBP-Y08197 sequestered Y08197 tightly into the CBP bromodomain active site.	Water	175-180	CREB binding protein	Homo sapiens	194-197
32072894-8	2020	Interestingly, in addition to some specific structural perturbations mediated by Asp1116 on the dynamics of CBP, our study revealed that the strong hydrogen bond interaction (N-H O) elicited in CBP-Y08197 sequestered Y08197 tightly into the CBP bromodomain active site.	Water	175-180	CREB binding protein	Homo sapiens	194-197
33155896-3	2020	The posterior hypophysis, through nerve connections with the hypothalamic nuclei, releases vasopressin and oxytocin responsible for water balance and social bonding, sexual reproduction and childbirth, respectively.	Water	132-137	arginine vasopressin	Homo sapiens	91-102
32342317-4	2020	After water loading and the injection of 0.015 nM exenatide (GLP-1 mimetic), the time of excretion of 50% of water was halved from 112 +- 4 to 57 +- 5 min (p < 0.01), and after the injection of 0.015 nM oxytocin, it decreased to 83 +- 6 min (p < 0.01).	Water	109-114	glucagon	Homo sapiens	61-66
31237219-5	2020	RESULTS: Angiotensin II (ANG II), beside stimulating aldosterone, vasopressin and CRH-ACTH release, sodium and water retention, thirst, and sympathetic nerve activity, exerts its effects on the immune system via the Angiotensin Type 1 Receptor (AT 1R) that is located in the brain, pituitary adrenal gland, and kidney.	Water	111-116	angiotensinogen	Homo sapiens	25-31
31832938-0	2020	Facile fabrication of magnetic phosphorylated chitosan for the removal of Co(II) in water treatment: separation properties and adsorption mechanisms.	Water	84-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
31760617-1	2020	Lead (Pb(II)) pollution in water poses a serious threat to human health in many parts of the world.	Water	27-32	submaxillary gland androgen regulated protein 3B	Homo sapiens	5-12
31639438-1	2020	Here, we demonstrate that the upregulation of catalase is required to compensate for the loss of nicotinamide nucleotide transhydrogenase (NNT) to maintain hydrogen peroxide (H2O2) steady-state levels in C57BL/6J liver mitochondria.	Water	175-179	catalase	Mus musculus	46-54
31885708-4	2020	Alkaline phosphatase (ALP) activity in H2O2-induced hADMSCs was also detected.	Water	39-43	alkaline phosphatase, placental	Homo sapiens	0-20
31885708-4	2020	Alkaline phosphatase (ALP) activity in H2O2-induced hADMSCs was also detected.	Water	39-43	alkaline phosphatase, placental	Homo sapiens	22-25
31639438-1	2020	Here, we demonstrate that the upregulation of catalase is required to compensate for the loss of nicotinamide nucleotide transhydrogenase (NNT) to maintain hydrogen peroxide (H2O2) steady-state levels in C57BL/6J liver mitochondria.	Water	175-179	nicotinamide nucleotide transhydrogenase	Mus musculus	97-137
31639438-5	2020	Further investigations into the H2O2 eliminating capacities of these mitochondria led to the novel observation that 6J mitochondria compensate for the loss of NNT by upregulating catalase.	Water	32-36	nicotinamide nucleotide transhydrogenase	Mus musculus	159-162
31639438-5	2020	Further investigations into the H2O2 eliminating capacities of these mitochondria led to the novel observation that 6J mitochondria compensate for the loss of NNT by upregulating catalase.	Water	32-36	catalase	Mus musculus	179-187
31639438-1	2020	Here, we demonstrate that the upregulation of catalase is required to compensate for the loss of nicotinamide nucleotide transhydrogenase (NNT) to maintain hydrogen peroxide (H2O2) steady-state levels in C57BL/6J liver mitochondria.	Water	175-179	nicotinamide nucleotide transhydrogenase	Mus musculus	139-142
31639438-8	2020	Inhibition of catalase with triazole compromised the capacity of 6J mitochondria to maintain H2O2 steady-state levels.	Water	93-97	catalase	Mus musculus	14-22
31639438-11	2020	However, catalase still played an integral in eliminating H2O2 in 6NJ liver mitochondria.	Water	58-62	catalase	Mus musculus	9-17
32086667-5	2020	In all cases, the water-soluble product of these PLD activities is choline.	Water	18-23	phospholipase D1	Homo sapiens	49-52
31639438-13	2020	Collectively, our findings demonstrate for the first time that 6J liver mitochondria compensate for the loss of NNT by increasing catalase levels for the maintenance of H2O2 steady-state levels.	Water	169-173	nicotinamide nucleotide transhydrogenase	Mus musculus	112-115
31639438-13	2020	Collectively, our findings demonstrate for the first time that 6J liver mitochondria compensate for the loss of NNT by increasing catalase levels for the maintenance of H2O2 steady-state levels.	Water	169-173	catalase	Mus musculus	130-138
31682917-4	2020	For example, TRPM2, TRPC5, TRPV1, and TRPA1 are known as redox sensors activated by hydrogen peroxide (H2O2), nitric oxide (NO), and electrophiles.	Water	103-107	transient receptor potential cation channel subfamily C member 5	Homo sapiens	20-25
31455467-2	2020	B12 is an important water-soluble vitamin, which is fortified externally in such nutritional formulations.	Water	20-25	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	0-3
29883228-6	2020	Morris water maze and Y-maze test were used to assess cognitive functions and open-field test and elevated plus maze were used to detect anxiety-like behaviors 4 weeks after seizure onset.Results: mTOR pathway was abnormally activated with two peaks after pilocarpine-induced seizures, and no difference of DCX-positive cells and body weight were noticed between control and pilocarpine-induced seizure rats.	Water	7-12	mtor	None	197-201
31749326-8	2020	In addition, PPAR-gamma was up-regulated by ACART and inhibition of PPAR-gamma abolished the regulatory effects of ACART on cell apoptosis and the expression of Bcl-2, Bax and Cyt-C under H2 O2 treatment.	Water	188-193	B cell leukemia/lymphoma 2	Mus musculus	161-166
31368050-10	2020	COPEPTIN AS DIAGNOSTIC TOOL IN THE POLYURIA POLYDIPSIA SYNDROME: We have recently shown that copeptin, without prior water deprivation, identifies patients with nephrogenic diabetes insipidus.	Water	117-122	arginine vasopressin	Homo sapiens	93-101
31368050-11	2020	On the other hand, for the more difficult differentiation between central diabetes insipidus and primary polydipsia, a copeptin level of 4.9 pmol/L stimulated with hypertonic saline infusion differentiates between these two entities with a high diagnostic accuracy, and is superior to the water deprivation test.	Water	289-294	arginine vasopressin	Homo sapiens	119-127
32863888-0	2020	Tender coconut water suppresses hepatic inflammation by activating AKT and JNK signaling pathways in an in vitro model of sepsis.	Water	15-20	AKT serine/threonine kinase 1	Rattus norvegicus	67-70
31646664-4	2020	The dose-dependent protective effects against H2 O2 -induced oxidative stress of the rutin-Lys MRPs may involve the inhibition of reactive oxygen species generation, enhancement of the superoxide dismutase and catalase activities, along with the activation of the Nrf2-dependent pathway and upregulation of phase II antioxidant genes (including NQO1, HO-1, GCLG, and GCLM).	Water	46-51	NFE2 like bZIP transcription factor 2	Homo sapiens	264-268
31646664-4	2020	The dose-dependent protective effects against H2 O2 -induced oxidative stress of the rutin-Lys MRPs may involve the inhibition of reactive oxygen species generation, enhancement of the superoxide dismutase and catalase activities, along with the activation of the Nrf2-dependent pathway and upregulation of phase II antioxidant genes (including NQO1, HO-1, GCLG, and GCLM).	Water	46-51	NAD(P)H quinone dehydrogenase 1	Homo sapiens	345-349
31646664-4	2020	The dose-dependent protective effects against H2 O2 -induced oxidative stress of the rutin-Lys MRPs may involve the inhibition of reactive oxygen species generation, enhancement of the superoxide dismutase and catalase activities, along with the activation of the Nrf2-dependent pathway and upregulation of phase II antioxidant genes (including NQO1, HO-1, GCLG, and GCLM).	Water	46-51	glutamate-cysteine ligase modifier subunit	Homo sapiens	367-371
31721213-2	2020	Therefore, we investigated the potential that an increase in skeletal muscle mitochondrial H2 O2 emission, potentially as a result of decreased ADP sensitivity, contributes to cellular redox stress and the induction of insulin resistance during short-term bed rest in twenty healthy males.	Water	91-96	insulin	Homo sapiens	219-226
31396995-1	2020	BACKGROUND AND AIM: PBK-1701TC is a novel sulfate tablet-based that contains 320 mg of simethicone and delivers 90% of the salt and water delivered by oral sulfate solution (OSS) preparation.	Water	132-137	PDZ binding kinase	Homo sapiens	20-23
31698185-1	2020	A "scorpionate" type precursor [bdtbpza = bis(3,5-di-t-butylpyrazol-1-yl)acetate] has been employed to synthesize two mononuclear ZnII and CoII derivatives, namely [Zn(bdtbpza)2 (H2O)2] 2.5CH3OH 2[(CH3)3C-C3H2N2-C(CH3)3] (1) and [Co(bdtbpza)2(CH3OH)4] (2) in good yield.	Water	179-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-143
33612626-1	2020	Vitamin B12 is a water soluble micronutrient found in animal foods.	Water	17-22	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
31833075-5	2020	Oxidation of PGD2 with two standard oxidants showed that 11d-TxB2 was formed only with H2 O2 but not with peracetic acid.	Water	87-92	prostaglandin D2 synthase	Homo sapiens	13-17
32294645-3	2020	METHODS: Sprague-Dawley rats were offered 20% fructose solution or tap water for 2 weeks, after which vascular reactivity was measured in isolated aortic rings.	Water	71-76	nuclear RNA export factor 1	Rattus norvegicus	67-70
31642174-7	2020	In a similar fashion, depression of the E-cadherin/beta-catenin complex mediated by TIMP-3 deletion and knockdown of beta-catenin by small interfering RNA (siRNA) were both capable of inducing caspase activation in isolated hepatocytes subjected to H2 O2 oxidative stress.	Water	249-254	cadherin 1	Mus musculus	40-50
31833075-6	2020	Byproducts of the H2 O2 -mediated oxidation were hydroperoxide derivatives and isomers of PGD2 .	Water	18-23	prostaglandin D2 synthase	Homo sapiens	90-94
31746361-0	2020	Rhizoma Paridis total saponins alleviate H2O2-induced oxidative stress injury by upregulating the Nrf2 pathway.	Water	41-45	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
31612412-8	2020	Molecular analyses indicated that selected extract dramatically up-regulated the expression of pap1+, which encodes the transcriptional factor Pap1 and ctt1+, which encodes catalase, following H2O2 treatment.	Water	193-197	polynucleotide adenylyltransferase PAP1	Saccharomyces cerevisiae S288C	95-99
31612412-8	2020	Molecular analyses indicated that selected extract dramatically up-regulated the expression of pap1+, which encodes the transcriptional factor Pap1 and ctt1+, which encodes catalase, following H2O2 treatment.	Water	193-197	polynucleotide adenylyltransferase PAP1	Saccharomyces cerevisiae S288C	143-147
31612412-8	2020	Molecular analyses indicated that selected extract dramatically up-regulated the expression of pap1+, which encodes the transcriptional factor Pap1 and ctt1+, which encodes catalase, following H2O2 treatment.	Water	193-197	catalase T	Saccharomyces cerevisiae S288C	152-156
31908576-5	2020	In cultured VSMCs, hydrogen peroxide (H2O2) dose-dependently induced senescence, which was associated with increased numbers of senescence-associated beta-galactosidase-positive cells, decreased expression of SMP30, and activation of p53-p21 and p16 pathways.	Water	38-42	tumor protein p53	Homo sapiens	234-237
31908576-5	2020	In cultured VSMCs, hydrogen peroxide (H2O2) dose-dependently induced senescence, which was associated with increased numbers of senescence-associated beta-galactosidase-positive cells, decreased expression of SMP30, and activation of p53-p21 and p16 pathways.	Water	38-42	cyclin dependent kinase inhibitor 2A	Homo sapiens	246-249
31746361-10	2020	In conclusion, RPTS alleviated H2O2-induced oxidative stress injury by upregulating the Nrf2 pathway.	Water	31-35	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
32138949-1	2020	Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) is the main hormone responsible for water maintenance in the body through the antidiuretic actions in the kidney.	Water	115-120	arginine vasopressin	Homo sapiens	0-11
31805556-1	2020	BACKGROUNDS/AIMS: To explore whether NLRP3 is involved in the development of cataract and to study the effect of NLRP3 on hydrogen peroxide (H2O2)-induced injury in human lens epithelial cells.	Water	141-145	NLR family pyrin domain containing 3	Homo sapiens	113-118
31805556-5	2020	RESULTS: NLRP3 expression significantly increased in H2O2-induced HLEB3 cells.	Water	53-57	NLR family pyrin domain containing 3	Homo sapiens	9-14
31805556-9	2020	The inhibition of NLRP3 obviously attenuated H2O2-induced oxidative stress injury of human lens epithelial cells via NF-kappaB signaling.	Water	45-49	NLR family pyrin domain containing 3	Homo sapiens	18-23
31865348-11	2020	In addition, EX4 markedly increased expression of NRF2, HO-1, and NQO-1 and significantly improved protein expression of NRF2 and HO-1 in H2O2-treated ARPE-19 cells, caused by increased nuclear NRF2 protein expression.	Water	138-142	NFE2 like bZIP transcription factor 2	Homo sapiens	121-125
31865348-11	2020	In addition, EX4 markedly increased expression of NRF2, HO-1, and NQO-1 and significantly improved protein expression of NRF2 and HO-1 in H2O2-treated ARPE-19 cells, caused by increased nuclear NRF2 protein expression.	Water	138-142	NFE2 like bZIP transcription factor 2	Homo sapiens	121-125
31865348-12	2020	NRF2 knockdown by targeted siRNA alleviated EX4-mediated HO-1 expression and significantly nullified EX4-mediated RPE cell protection against H2O2.	Water	142-146	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
31994353-8	2020	Urine vasopressin in ipragliflozin-treated rats was negatively and positively associated with fluid balance and TcH2O, respectively.	Water	112-117	arginine vasopressin	Rattus norvegicus	6-17
31994353-11	2020	In conclusion, the SGLT2 inhibitor ipragliflozin induced a sustained glucosuria, diuresis, and natriuresis, with compensatory increases in fluid intake and vasopressin-induced TcH2O in proportion to the reduced fluid balance to maintain BFV.	Water	176-181	arginine vasopressin	Rattus norvegicus	156-167
32612811-2	2020	In this study, we examined the accuracies of two popular water models, TIP3P and TIP4P, in the molecular dynamics simulations of erythrocyte aquaporins (AQP1 and AQP3).	Water	57-62	aquaporin 1 (Colton blood group)	Homo sapiens	153-157
32138949-4	2020	The effects of AVP peptide includes activation of V2 receptors which stimulate the formation of cyclic AMP (cAMP) and phosphorylation of water channels aquaporin 2 (AQP2) in the collecting duct.	Water	137-142	arginine vasopressin	Homo sapiens	15-18
32138950-6	2020	In this review, we discuss the role of vasopressin and its interaction with V-receptor subtypes in natriuresis and for stabilizing the physicochemical parameters of the internal environment and water-salt homeostasis in humans.	Water	194-199	arginine vasopressin	Homo sapiens	39-50
31869409-9	2020	Treatment with H2O2 increased apoptosis and the activity of the pro-apoptotic factors caspase-8 and caspase-3, both of which were attenuated by TUDCA.	Water	15-19	caspase 3	Homo sapiens	100-109
31707353-8	2020	Impaired inflammasome activation in G6PD-kd THP-1 cells was mediated by a decrease in the production of reactive oxygen species (ROS) by NOX signaling, while treatment with hydrogen peroxide (H2O2) enhanced inflammasome activation in G6PD-kd THP-1 cells.	Water	192-196	GLI family zinc finger 2	Homo sapiens	242-247
31546170-0	2020	Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane.	Water	53-57	aquaporin 11	Homo sapiens	6-18
31546170-2	2020	To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with "peroxiporin" activity (AQP3, AQP8, AQP9).	Water	37-41	aquaporin 8	Homo sapiens	146-150
31546170-2	2020	To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with "peroxiporin" activity (AQP3, AQP8, AQP9).	Water	37-41	aquaporin 9	Homo sapiens	152-156
31546170-3	2020	Here, we exploit different organelle-targeted H2O2-sensitive probes to show that also AQP11 efficiently conduits H2O2.	Water	46-50	aquaporin 11	Homo sapiens	86-91
31546170-3	2020	Here, we exploit different organelle-targeted H2O2-sensitive probes to show that also AQP11 efficiently conduits H2O2.	Water	113-117	aquaporin 11	Homo sapiens	86-91
32879248-8	2020	The crystal structure of HP-alpha-CD, HP-beta-CD, and HP-gamma-CD showed amorphous at different water activity conditions.	Water	96-101	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	28-36
32879248-8	2020	The crystal structure of HP-alpha-CD, HP-beta-CD, and HP-gamma-CD showed amorphous at different water activity conditions.	Water	96-101	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	41-48
31799853-7	2019	The surface wettability study reveals that the PFO-PDDA/PSS films are amphiphobic with water and oil contact angles (CAs) of 114 +- 2 and 64 +- 2 , respectively, while PSS-substituted PFO-(PDDA/PSS) films are amphiphilic with water and oil CAs of 6 +- 1 and 0 , respectively.	Water	87-92	PSS	Homo sapiens	56-59
31799853-7	2019	The surface wettability study reveals that the PFO-PDDA/PSS films are amphiphobic with water and oil contact angles (CAs) of 114 +- 2 and 64 +- 2 , respectively, while PSS-substituted PFO-(PDDA/PSS) films are amphiphilic with water and oil CAs of 6 +- 1 and 0 , respectively.	Water	226-231	PSS	Homo sapiens	56-59
31799853-7	2019	The surface wettability study reveals that the PFO-PDDA/PSS films are amphiphobic with water and oil contact angles (CAs) of 114 +- 2 and 64 +- 2 , respectively, while PSS-substituted PFO-(PDDA/PSS) films are amphiphilic with water and oil CAs of 6 +- 1 and 0 , respectively.	Water	226-231	PSS	Homo sapiens	168-171
31799853-7	2019	The surface wettability study reveals that the PFO-PDDA/PSS films are amphiphobic with water and oil contact angles (CAs) of 114 +- 2 and 64 +- 2 , respectively, while PSS-substituted PFO-(PDDA/PSS) films are amphiphilic with water and oil CAs of 6 +- 1 and 0 , respectively.	Water	226-231	PSS	Homo sapiens	168-171
32138949-1	2020	Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) is the main hormone responsible for water maintenance in the body through the antidiuretic actions in the kidney.	Water	115-120	arginine vasopressin	Homo sapiens	24-44
32138949-1	2020	Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) is the main hormone responsible for water maintenance in the body through the antidiuretic actions in the kidney.	Water	115-120	arginine vasopressin	Homo sapiens	46-49
32138949-1	2020	Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) is the main hormone responsible for water maintenance in the body through the antidiuretic actions in the kidney.	Water	115-120	arginine vasopressin	Homo sapiens	52-72
32138949-1	2020	Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) is the main hormone responsible for water maintenance in the body through the antidiuretic actions in the kidney.	Water	115-120	arginine vasopressin	Homo sapiens	74-77
31773940-6	2019	Firstly, upon the arrival of TDPAD/PLL-RT/pDNA (abbreviated as T(PD)) at the tumor site by the EPR effect, TDPAD reacts with excess H2O2 in tumor tissue, contributing to the detachment of TDPAD, PLL-RT then mediates the enhanced endocytosis of pDNA encoding shVEGF and significantly down-regulates expression of vascular endothelial growth factor (VEGF) in tumor tissue, exhibiting an outstanding antitumor effect.	Water	132-136	vascular endothelial growth factor A	Homo sapiens	312-346
31773940-6	2019	Firstly, upon the arrival of TDPAD/PLL-RT/pDNA (abbreviated as T(PD)) at the tumor site by the EPR effect, TDPAD reacts with excess H2O2 in tumor tissue, contributing to the detachment of TDPAD, PLL-RT then mediates the enhanced endocytosis of pDNA encoding shVEGF and significantly down-regulates expression of vascular endothelial growth factor (VEGF) in tumor tissue, exhibiting an outstanding antitumor effect.	Water	132-136	vascular endothelial growth factor A	Homo sapiens	260-264
31706864-3	2019	Considering the ability of hydroxypropyl-beta-cyclodextrin (HP-beta-CD, 100 mM) to increase the water solubility of BUD (SHP-beta-CD = 4.3 10-3 M; K1:1 = 861.11 M-1), a mucoadhesive thiolated HP-beta-CD (HP-beta-CD-SH) was synthesized and characterized by mass spectroscopy, 1H- and 13C NMR techniques.	Water	96-101	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	63-70
31888046-7	2019	In vivo, dietary supplementation with COS alleviated the H2O2-induced oxidative damage, evidenced by comparatively increasing activity of SOD, CAT, GSH-Px, GSH, and T-AOC, and comparatively decreasing level of MDA in serum, liver, spleen, and kidney.	Water	57-61	catalase	Rattus norvegicus	143-146
31853650-11	2019	By using the tetramethylbenzidine/H2O2 chromogenic system, the absorbance at 652 nm increases linearly in the 0.3 to 200 ng L-1 HIF-1alpha concentration range.	Water	34-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
31577966-7	2019	UV/H2O2 pre-oxidation increased total CX3R-type DBP formation, during SDS chlorination, whereas SDS in-situ chloramination or pre-chlorination followed by chloramination of UV/H2O2-treated water produced lower total CX3R-type DBPs than water without UV/H2O2 pre-oxidation.	Water	3-7	D-box binding PAR bZIP transcription factor	Homo sapiens	48-51
31577966-8	2019	Nevertheless, the DBP-associated toxicity of water with UV/H2O2 pre-oxidation was substantially lower than the toxicity for water without UV/H2O2 pre-oxidation, decreased by 24.1-82.7%.	Water	59-63	D-box binding PAR bZIP transcription factor	Homo sapiens	18-21
31577966-8	2019	Nevertheless, the DBP-associated toxicity of water with UV/H2O2 pre-oxidation was substantially lower than the toxicity for water without UV/H2O2 pre-oxidation, decreased by 24.1-82.7%.	Water	141-145	D-box binding PAR bZIP transcription factor	Homo sapiens	18-21
31577966-10	2019	The best DBP concentration and DBP-associated toxicity abatement results were achieved for water treated by UV/H2O2 coupled with in-situ chloramination treatment.	Water	111-115	D-box binding PAR bZIP transcription factor	Homo sapiens	9-12
31577966-10	2019	The best DBP concentration and DBP-associated toxicity abatement results were achieved for water treated by UV/H2O2 coupled with in-situ chloramination treatment.	Water	111-115	D-box binding PAR bZIP transcription factor	Homo sapiens	31-34
31748764-3	2019	Aside from providing water solubility to various porphyrinic structures, the beta-CD framework can also modulate and control the reactivity of the metal core of the porphyrin.	Water	21-26	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	77-84
31851715-6	2019	We identified the critical role of the Ca2+-permeable TRPC3 channel in osmosensitivity and water permeability in the CD.	Water	91-96	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	54-59
31851715-7	2019	We further demonstrated that TRPC3 -/- mice exhibit impaired urinary concentration, larger urinary volume and a greater weight loss in response to water deprivation despite increased AVP levels and AQP2 abundance.	Water	147-152	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	29-34
31851715-8	2019	TRPC3 deletion interfered with AQP2 translocation to the plasma membrane in response to water deprivation.	Water	88-93	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	0-5
31694910-7	2019	With stimulation by PMA/ionomycin, TNF-alpha, or H2O2, PBMCs from ulcerative colitis patients treated with NX-13 had decreased NF-kappaB activity, TNF-alpha+ and IFN-gamma+ CD4+ T cells and overall production of IL-6, MCP1, and IL-8.	Water	49-53	tumor necrosis factor	Homo sapiens	147-156
31694910-7	2019	With stimulation by PMA/ionomycin, TNF-alpha, or H2O2, PBMCs from ulcerative colitis patients treated with NX-13 had decreased NF-kappaB activity, TNF-alpha+ and IFN-gamma+ CD4+ T cells and overall production of IL-6, MCP1, and IL-8.	Water	49-53	interferon gamma	Homo sapiens	162-171
31706864-4	2019	Phase-solubility studies demonstrated the capability of HP-beta-CD-SH (100 mM) to form a reversible water soluble inclusion complex with BUD (SHP-beta-CD-SH = 10.9 10-3 M; K1:1 = 2013.52 M-1), which increases its permanence on the target site as proved by mucoadhesive studies on porcine oesophagus mucosa.	Water	100-105	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	59-66
31871440-5	2019	Here, we used a modified Amplex Red assay to investigate the inflammatory and microbial regulation of IEC-generated H2O2 and the potential role of Duox2, a NADPH oxidase that is an important source of H2O2.	Water	201-205	dual oxidase 2	Mus musculus	147-152
32140643-1	2020	Objective: To investigate the effect of water extract of Gastrodiae Rhizoma (GR) on the development of acquired temporal lobe epilepsy (TLE) and on regulating the expression of the mammalian target of rapamycin (mTOR) and semaphorin 3F (SEMA3F).	Water	40-45	mechanistic target of rapamycin kinase	Homo sapiens	181-210
32140643-1	2020	Objective: To investigate the effect of water extract of Gastrodiae Rhizoma (GR) on the development of acquired temporal lobe epilepsy (TLE) and on regulating the expression of the mammalian target of rapamycin (mTOR) and semaphorin 3F (SEMA3F).	Water	40-45	mechanistic target of rapamycin kinase	Homo sapiens	212-216
31871440-6	2019	We found that colonoids respond to interferon-gamma and flagellin by enhancing production of H2O2 in a Duox2-mediated fashion.	Water	93-97	interferon gamma	Mus musculus	35-51
31871440-6	2019	We found that colonoids respond to interferon-gamma and flagellin by enhancing production of H2O2 in a Duox2-mediated fashion.	Water	93-97	dual oxidase 2	Mus musculus	103-108
31915512-0	2019	Coenzyme Q10 Regulation of Apoptosis and Oxidative Stress in H2O2 Induced BMSC Death by Modulating the Nrf-2/NQO-1 Signaling Pathway and Its Application in a Model of Spinal Cord Injury.	Water	61-65	NFE2 like bZIP transcription factor 2	Homo sapiens	103-108
31726824-0	2019	Destabilization of Insulin Hexamer in Water-Ethanol Binary Mixture.	Water	38-43	insulin	Homo sapiens	19-26
31726824-2	2019	X-ray crystal structures suggest that ethanol replaces water molecules inside the insulin hexamer cavity.	Water	55-60	insulin	Homo sapiens	82-89
31915512-0	2019	Coenzyme Q10 Regulation of Apoptosis and Oxidative Stress in H2O2 Induced BMSC Death by Modulating the Nrf-2/NQO-1 Signaling Pathway and Its Application in a Model of Spinal Cord Injury.	Water	61-65	NAD(P)H quinone dehydrogenase 1	Homo sapiens	109-114
31886177-3	2019	Our docking and molecular dynamics studies showed that compared to JQ1, ITH-47 showed a similar binding mode with hydrogen bonds forming between the ligand nitrogens of the pyrazole, ASN99, and water of the BRD4 protein.	Water	194-199	bromodomain containing 4	Homo sapiens	207-211
31754682-7	2019	The introduction of Au enhances the electron transfer efficiency, which endows the sensor with good reduction ability for H2O2 at 0 V over a wide linear range (0.5-200 muM and 210-3000 muM) and with a low detection limit (0.23 muM (S/N = 3)), which fulfills the requirements for the detection of H2O2 in a biological system.	Water	122-126	latexin	Homo sapiens	168-171
31754682-7	2019	The introduction of Au enhances the electron transfer efficiency, which endows the sensor with good reduction ability for H2O2 at 0 V over a wide linear range (0.5-200 muM and 210-3000 muM) and with a low detection limit (0.23 muM (S/N = 3)), which fulfills the requirements for the detection of H2O2 in a biological system.	Water	122-126	latexin	Homo sapiens	185-188
31754682-7	2019	The introduction of Au enhances the electron transfer efficiency, which endows the sensor with good reduction ability for H2O2 at 0 V over a wide linear range (0.5-200 muM and 210-3000 muM) and with a low detection limit (0.23 muM (S/N = 3)), which fulfills the requirements for the detection of H2O2 in a biological system.	Water	122-126	latexin	Homo sapiens	185-188
31754682-7	2019	The introduction of Au enhances the electron transfer efficiency, which endows the sensor with good reduction ability for H2O2 at 0 V over a wide linear range (0.5-200 muM and 210-3000 muM) and with a low detection limit (0.23 muM (S/N = 3)), which fulfills the requirements for the detection of H2O2 in a biological system.	Water	296-300	latexin	Homo sapiens	168-171
31754682-7	2019	The introduction of Au enhances the electron transfer efficiency, which endows the sensor with good reduction ability for H2O2 at 0 V over a wide linear range (0.5-200 muM and 210-3000 muM) and with a low detection limit (0.23 muM (S/N = 3)), which fulfills the requirements for the detection of H2O2 in a biological system.	Water	296-300	latexin	Homo sapiens	185-188
31754682-7	2019	The introduction of Au enhances the electron transfer efficiency, which endows the sensor with good reduction ability for H2O2 at 0 V over a wide linear range (0.5-200 muM and 210-3000 muM) and with a low detection limit (0.23 muM (S/N = 3)), which fulfills the requirements for the detection of H2O2 in a biological system.	Water	296-300	latexin	Homo sapiens	185-188
31827075-1	2019	Claudin6 (CLDN6), a member of the tight junction family, is a molecule involved in intercellular adhesion, acting as a physical barrier that prevents solutes and water from freely passing through the extracellular space.	Water	162-167	claudin 6	Homo sapiens	0-8
31827075-1	2019	Claudin6 (CLDN6), a member of the tight junction family, is a molecule involved in intercellular adhesion, acting as a physical barrier that prevents solutes and water from freely passing through the extracellular space.	Water	162-167	claudin 6	Homo sapiens	10-15
31348857-5	2019	Under water (no added salt), excellent lubrication, with friction coefficients down to 10-3-10-4, up to contact stresses of 6.5 MPa (comparable to those in the major joints) was observed between two surfaces bearing such PEO-PC complexes.	Water	6-11	twinkle mtDNA helicase	Homo sapiens	221-224
31425994-5	2019	The average total dissolved As (dissolved AsT) concentrations was 47.2 +- 30.8 mug L-1 (15.3-110 mug L-1) in groundwater in Neogene aquifer (GW1), while it was 97.1 +- 30.6 mug L-1 (45-144 mug L-1) in Quaternary floodplain aquifer (GW2), with all samples exceeding WHO"s guideline for dissolved AsT in safe drinking water of 10 mug L-1.	Water	115-120	solute carrier family 17 member 5	Homo sapiens	42-45
31812951-4	2019	In SH-SY5Y neuronal cells and primary human neuron cultures, H2O2 downregulated Lnc-EPIC1 and key MYC targets (Cyclin A1, CDC20 and CDC45).	Water	61-65	cell division cycle 45	Homo sapiens	132-137
31817362-7	2019	These results demonstrate that ASIV treatment effectively protects against H2O2-induced oxidative damage in calf small intestine epithelial cells through the activation of the NFE2L2-antioxidant response element signaling pathway.	Water	75-79	NFE2 like bZIP transcription factor 2	Bos taurus	176-182
31062603-4	2019	The self-assembled nanomicelles (NMs) of FG-C18 in water were prepared by an ultrasonication method.	Water	51-56	Bardet-Biedl syndrome 9	Homo sapiens	44-47
31400337-1	2019	BACKGROUND: Arginine vasopressin is a nonapeptide hormone with effects on intracellular water transport and arterial tone that is used in distributive shock and following cardiopulmonary bypass.	Water	88-93	arginine vasopressin	Homo sapiens	21-32
31550675-8	2019	Then, miR-429 was identified as downstream effector for SCAMP1-mediated tumorigenesis under H2O2 treatment.	Water	92-96	microRNA 429	Homo sapiens	6-13
31570002-8	2019	Furthermore, phosphomimetic Cytc had decreased cardiolipin peroxidase activity and is more stable in the presence of H2O2.	Water	117-121	cytochrome c, somatic	Homo sapiens	28-32
31629255-12	2019	Furthermore, SOD1, SOD2 and catalase mRNA levels were increased by pre-treatment with CHWDT in H2O2 and LPS-stimulated RAW 264.7 cells, as well as in LPS-treated U937 and HUVECs.	Water	95-99	superoxide dismutase 1, soluble	Mus musculus	13-17
31629255-12	2019	Furthermore, SOD1, SOD2 and catalase mRNA levels were increased by pre-treatment with CHWDT in H2O2 and LPS-stimulated RAW 264.7 cells, as well as in LPS-treated U937 and HUVECs.	Water	95-99	superoxide dismutase 2, mitochondrial	Mus musculus	19-23
31629255-12	2019	Furthermore, SOD1, SOD2 and catalase mRNA levels were increased by pre-treatment with CHWDT in H2O2 and LPS-stimulated RAW 264.7 cells, as well as in LPS-treated U937 and HUVECs.	Water	95-99	catalase	Mus musculus	28-36
31561043-8	2019	Moreover, in vivo behavioral studies signified learning and memory improvement by compound 49 in scopolamine- and Abeta-induced cognitive dysfunctions performed on Y-maze and Morris water maze.	Water	182-187	amyloid beta precursor protein	Homo sapiens	114-119
31715384-6	2019	H2O2 exerts its inhibition on the IP3 receptor as Ca2+ release evoked by photolysis of caged IP3 was supressed by H2O2.	Water	0-4	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	34-46
31715384-6	2019	H2O2 exerts its inhibition on the IP3 receptor as Ca2+ release evoked by photolysis of caged IP3 was supressed by H2O2.	Water	114-118	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	34-46
31585206-7	2019	Further studies showed that H2O2 regulated biological rhythm by PRX2-STAT3-REV-ERBalpha/beta pathway.	Water	28-32	signal transducer and activator of transcription 3	Mus musculus	69-74
31378942-6	2019	We conclude that rain and fog water, respectively, cause contrasting trends regarding cyanobacterial species richness in the edaphic and lithic microhabitats.	Water	30-35	zinc finger protein, FOG family member 1	Homo sapiens	26-29
30215264-8	2019	MiR-126EC-/- mice exhibit significant cognitive impairment, decreased CBF, myelin density and axon density, increased inflammation, and significant water channel and glymphatic dysfunction compared to miR-126fl/fl mice.	Water	148-153	microRNA 126a	Mus musculus	0-12
31302633-12	2019	Water maze escape latency was significantly elevated in homozygous AppNL-G-F mice compared to wild-type at ten months of age and was associated with high TSPO binding.	Water	0-5	translocator protein	Mus musculus	154-158
31768048-3	2019	Using an unbiased method to screen for H2O2-sensitive transcription factors, we discovered that rhythmic redox control of CLOCK directly by endogenous H2O2 oscillations is required for proper intracellular clock function.	Water	39-43	circadian locomotor output cycles kaput	Mus musculus	122-127
31768048-3	2019	Using an unbiased method to screen for H2O2-sensitive transcription factors, we discovered that rhythmic redox control of CLOCK directly by endogenous H2O2 oscillations is required for proper intracellular clock function.	Water	39-43	circadian locomotor output cycles kaput	Mus musculus	206-211
31768048-3	2019	Using an unbiased method to screen for H2O2-sensitive transcription factors, we discovered that rhythmic redox control of CLOCK directly by endogenous H2O2 oscillations is required for proper intracellular clock function.	Water	151-155	circadian locomotor output cycles kaput	Mus musculus	122-127
31768048-3	2019	Using an unbiased method to screen for H2O2-sensitive transcription factors, we discovered that rhythmic redox control of CLOCK directly by endogenous H2O2 oscillations is required for proper intracellular clock function.	Water	151-155	circadian locomotor output cycles kaput	Mus musculus	206-211
31768048-4	2019	Importantly, perturbations in the rhythm of H2O2 levels induced by the loss of p66Shc, which oscillates rhythmically in the liver and suprachiasmatic nucleus (SCN) of mice, disturb the rhythmic redox control of CLOCK function, reprogram hepatic transcriptome oscillations, lengthen the circadian period in mice and modulate light-induced clock resetting.	Water	44-48	circadian locomotor output cycles kaput	Mus musculus	211-216
31768048-4	2019	Importantly, perturbations in the rhythm of H2O2 levels induced by the loss of p66Shc, which oscillates rhythmically in the liver and suprachiasmatic nucleus (SCN) of mice, disturb the rhythmic redox control of CLOCK function, reprogram hepatic transcriptome oscillations, lengthen the circadian period in mice and modulate light-induced clock resetting.	Water	44-48	circadian locomotor output cycles kaput	Mus musculus	338-343
32198324-3	2019	The monitoring of Pb(II) ions concentrations in drinking water is essential for human health and a safe environment.	Water	57-62	submaxillary gland androgen regulated protein 3B	Homo sapiens	18-24
31728857-8	2019	Further experiments verified that PF pretreatment alleviated H2O2-induced oxidative stress through increasing cell viability, inhibiting cell apoptosis, reducing ROS generation and activating JAK2/STAT3 and ERK1/2 pathways.	Water	61-65	signal transducer and activator of transcription 3	Mus musculus	197-202
31728857-11	2019	These results indicated that PF can alleviate H2O2-induced oxidative stress by down-regulation of miR-135a via activation of JAK2/STAT3 and ERK1/2 pathways.	Water	46-50	signal transducer and activator of transcription 3	Mus musculus	130-135
31781934-9	2019	Moreover, basal ROS (H2O2) levels and their modification under abiotic stresses were altered in TOR complex mutants.	Water	21-25	target of rapamycin	Arabidopsis thaliana	96-99
31801194-3	2019	Biological evaluation revealed that compounds 4, 7-9, 12, and 13 display neuroprotective activities in H2O2-induced HT-22 cells with 4, 8, and 9 occurring in a concentration-dependent manner and 7, 12, and 13 reaching the maximum effects at 20 muM.	Water	103-107	latexin	Homo sapiens	244-247
31746021-6	2019	Moreover, we found that miR-142 reduced the Bcl-2/Bax ratio and upregulated hydrogen peroxide (H2 O2 )-induced caspase-3 expression.	Water	95-100	microRNA 142	Mus musculus	24-31
31783479-4	2019	CeO2NPs did not modify HepG2 cell viability in basal conditions but reduced H2O2- and lipopolysaccharide (LPS)-induced cell death and prevented H2O2-induced overexpression of MPO, PTGS1 and iNOS.	Water	144-148	myeloperoxidase	Homo sapiens	175-178
31783479-4	2019	CeO2NPs did not modify HepG2 cell viability in basal conditions but reduced H2O2- and lipopolysaccharide (LPS)-induced cell death and prevented H2O2-induced overexpression of MPO, PTGS1 and iNOS.	Water	144-148	prostaglandin-endoperoxide synthase 1	Homo sapiens	180-185
31783479-5	2019	Phosphoproteomic analysis showed that CeO2NPs reverted the H2O2-mediated increase in the phosphorylation of peptides related to cellular proliferation, stress response, and gene transcription regulation, and interfered with H2O2 effects on mTOR, MAPK/ERK, CK2A1 and PKACA signaling pathways.	Water	59-63	mechanistic target of rapamycin kinase	Homo sapiens	240-244
31783479-5	2019	Phosphoproteomic analysis showed that CeO2NPs reverted the H2O2-mediated increase in the phosphorylation of peptides related to cellular proliferation, stress response, and gene transcription regulation, and interfered with H2O2 effects on mTOR, MAPK/ERK, CK2A1 and PKACA signaling pathways.	Water	59-63	mitogen-activated protein kinase 1	Homo sapiens	251-254
31783479-5	2019	Phosphoproteomic analysis showed that CeO2NPs reverted the H2O2-mediated increase in the phosphorylation of peptides related to cellular proliferation, stress response, and gene transcription regulation, and interfered with H2O2 effects on mTOR, MAPK/ERK, CK2A1 and PKACA signaling pathways.	Water	224-228	mechanistic target of rapamycin kinase	Homo sapiens	240-244
31748248-2	2019	In this study, we aimed to elucidate the regulatory mechanism of an atypical yeast AP-1-like protein, Yap1, in the stress response and virulence of Cryptococcus neoformans YAP1 expression was induced and involved not only by oxidative stresses, such as H2O2 and diamide, but also by other environmental stresses, such as osmotic and membrane-destabilizing stresses.	Water	253-257	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	102-106
31748248-2	2019	In this study, we aimed to elucidate the regulatory mechanism of an atypical yeast AP-1-like protein, Yap1, in the stress response and virulence of Cryptococcus neoformans YAP1 expression was induced and involved not only by oxidative stresses, such as H2O2 and diamide, but also by other environmental stresses, such as osmotic and membrane-destabilizing stresses.	Water	253-257	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	172-176
31693361-10	2019	A structure of N140A-TDG bound to cadC DNA provides the first high-resolution insight into how enzyme-substrate interactions, including water molecules, are impacted by depleting the conserved Asn, informing its role in binding and addition of the nucleophilic water molecule.	Water	136-141	thymine DNA glycosylase	Homo sapiens	21-24
31693361-10	2019	A structure of N140A-TDG bound to cadC DNA provides the first high-resolution insight into how enzyme-substrate interactions, including water molecules, are impacted by depleting the conserved Asn, informing its role in binding and addition of the nucleophilic water molecule.	Water	261-266	thymine DNA glycosylase	Homo sapiens	21-24
31493807-5	2019	The capability of the system to determine CS2 level in water samples was also demonstrated.	Water	55-60	chorionic somatomammotropin hormone 2	Homo sapiens	42-45
31642668-9	2019	In vitro, pterostilbene markedly promoted the expression and activity of CAT and decreased ox-LDL-mediated VSMC proliferation and intracellular H2O2 production, which was abolished by CAT siRNA knockdown or inhibition.	Water	144-148	catalase	Mus musculus	184-187
31746021-9	2019	In addition, TLR4 overexpression considerably ablated the protective effects of miR-142 in terms of the cell viability of H2 O2 -treated NRCs.	Water	122-127	toll-like receptor 4	Mus musculus	13-17
31746021-9	2019	In addition, TLR4 overexpression considerably ablated the protective effects of miR-142 in terms of the cell viability of H2 O2 -treated NRCs.	Water	122-127	microRNA 142	Mus musculus	80-87
31635452-10	2019	However, the addition of H2O2, when the background NH2Cl level was above 2 mg L-1 (as Cl2) provided limited improvement in treatment efficiency.	Water	25-29	L1 cell adhesion molecule	Homo sapiens	78-81
31472250-1	2019	Extracellular beta-amyloid (Abeta) plaque deposits and inflammatory immune activation are thought to alter various aspects of tissue microstructure, such as extracellular free water, fractional anisotropy and diffusivity, as well as the density and geometric arrangement of axonal processes.	Water	176-181	histocompatibility 2, class II antigen A, beta 1	Mus musculus	28-33
31461688-4	2019	Our high resolution co-crystal structures of 47/BRD2 BD1 and BD2 showed that the triazole group of 47, water molecules, H433 and N429 in BRD2 BD2 established a water-bridged H-bonding network, which is responsible for the observed selectivities.	Water	103-108	defensin beta 1	Homo sapiens	53-56
31461688-4	2019	Our high resolution co-crystal structures of 47/BRD2 BD1 and BD2 showed that the triazole group of 47, water molecules, H433 and N429 in BRD2 BD2 established a water-bridged H-bonding network, which is responsible for the observed selectivities.	Water	103-108	defensin beta 4A	Homo sapiens	61-64
31461688-4	2019	Our high resolution co-crystal structures of 47/BRD2 BD1 and BD2 showed that the triazole group of 47, water molecules, H433 and N429 in BRD2 BD2 established a water-bridged H-bonding network, which is responsible for the observed selectivities.	Water	103-108	defensin beta 4A	Homo sapiens	142-145
31461688-4	2019	Our high resolution co-crystal structures of 47/BRD2 BD1 and BD2 showed that the triazole group of 47, water molecules, H433 and N429 in BRD2 BD2 established a water-bridged H-bonding network, which is responsible for the observed selectivities.	Water	160-165	defensin beta 1	Homo sapiens	53-56
31461688-4	2019	Our high resolution co-crystal structures of 47/BRD2 BD1 and BD2 showed that the triazole group of 47, water molecules, H433 and N429 in BRD2 BD2 established a water-bridged H-bonding network, which is responsible for the observed selectivities.	Water	160-165	defensin beta 4A	Homo sapiens	61-64
31461688-4	2019	Our high resolution co-crystal structures of 47/BRD2 BD1 and BD2 showed that the triazole group of 47, water molecules, H433 and N429 in BRD2 BD2 established a water-bridged H-bonding network, which is responsible for the observed selectivities.	Water	160-165	defensin beta 4A	Homo sapiens	142-145
31730025-2	2019	CASE PRESENTATION: We now designed a new water-soluble synthetic Pam3Cys-derivative, named XS15 and characterized it in vitro by a TLR2 NF-kappaB luciferase reporter assay.	Water	41-46	toll like receptor 2	Homo sapiens	131-135
31730025-2	2019	CASE PRESENTATION: We now designed a new water-soluble synthetic Pam3Cys-derivative, named XS15 and characterized it in vitro by a TLR2 NF-kappaB luciferase reporter assay.	Water	41-46	nuclear factor kappa B subunit 1	Homo sapiens	136-145
31624816-3	2019	In vitro addition of a trilysine peptide onto a guanine radical cation generated in a TGT oligonucleotide is so efficient that competitive addition of a water molecule, giving rise to 8-oxo-7,8-dihydroguanine, is not observed.	Water	153-158	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	86-89
31497810-0	2019	Water-mediated proton conduction in Ni(ii) and Co(ii) benzenetriphosphonates.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-41
31497810-0	2019	Water-mediated proton conduction in Ni(ii) and Co(ii) benzenetriphosphonates.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
31827713-4	2019	A catalase is one of the crucial antioxidant enzymes that mitigates oxidative stress to a considerable extent by destroying cellular hydrogen peroxide to produce water and oxygen.	Water	162-167	catalase	Homo sapiens	2-10
31400345-0	2019	Temperature-dependent viscosity dominated transport control through AQP1 water channel.	Water	73-78	aquaporin 1 (Colton blood group)	Homo sapiens	68-72
31400345-4	2019	Otherwise, proton or hydronium (ion) transport through AQP1 at room temperature manifests like a molecular fluid with a correspondingly lower viscosity, such as water (H2O), and then exclusion of proton or hydronium (ion) through AQP1 will not occur.	Water	161-166	aquaporin 1 (Colton blood group)	Homo sapiens	55-59
31400345-4	2019	Otherwise, proton or hydronium (ion) transport through AQP1 at room temperature manifests like a molecular fluid with a correspondingly lower viscosity, such as water (H2O), and then exclusion of proton or hydronium (ion) through AQP1 will not occur.	Water	168-171	aquaporin 1 (Colton blood group)	Homo sapiens	55-59
31827676-8	2019	Our results showed that decreased methylation levels of ALP and RUNX2 were induced by H2O2 treatment in hMSCs cultivated in the 3D scaffolds.	Water	86-90	RUNX family transcription factor 2	Homo sapiens	64-69
31827676-10	2019	The hypomethylation of ALP and RUNX2 induced by H2O2 treatment was abolished by Dnmt3a overexpression.	Water	48-52	RUNX family transcription factor 2	Homo sapiens	31-36
31814699-12	2019	An in vitro study suggested that GPX3-AS inhibited H2O2-induced SRA01/04 cell apoptosis.	Water	51-55	glutathione peroxidase 3	Homo sapiens	33-37
31814699-15	2019	In addition, GPX3-AS inhibited H2O2-induced SRA01/04 cell apoptosis by upregulating GPX3 expression.	Water	31-35	glutathione peroxidase 3	Homo sapiens	13-17
31814699-15	2019	In addition, GPX3-AS inhibited H2O2-induced SRA01/04 cell apoptosis by upregulating GPX3 expression.	Water	31-35	glutathione peroxidase 3	Homo sapiens	84-88
31705012-6	2019	ANP also suppressed the neural activity at the "hindbrain" region for the swallowing reflex, and the maintenance of buccopharyngeal water due to the swallowing inhibition may attenuate the motivation to move to water.	Water	211-216	natriuretic peptide A	Homo sapiens	0-3
31705139-8	2019	The bound dTMP mimicked the methylene intermediate from dCMP to 5"-hydroxymethy-dCMP, and a critical water molecule for the final hydroxylation was convincingly identified.	Water	101-106	cmp	Drosophila melanogaster	56-60
31705139-8	2019	The bound dTMP mimicked the methylene intermediate from dCMP to 5"-hydroxymethy-dCMP, and a critical water molecule for the final hydroxylation was convincingly identified.	Water	101-106	cmp	Drosophila melanogaster	80-84
31553176-5	2019	However, the laccase-ABTS mediator was the most effective and enhanced I- uptake by HA up to 13.5 mg/g, compared to 1.9 mg/g for the LPO-H2O2.	Water	137-141	lactoperoxidase	Homo sapiens	133-136
31708994-7	2019	Initial exposure to H2O2 or TNFalpha enhanced SF senescence and increased mRNA expression of IL6, CXCL8, CCL2 and MMP3 and proteins secretion.	Water	20-24	interleukin 6	Homo sapiens	93-96
31708994-7	2019	Initial exposure to H2O2 or TNFalpha enhanced SF senescence and increased mRNA expression of IL6, CXCL8, CCL2 and MMP3 and proteins secretion.	Water	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	98-103
31708994-7	2019	Initial exposure to H2O2 or TNFalpha enhanced SF senescence and increased mRNA expression of IL6, CXCL8, CCL2 and MMP3 and proteins secretion.	Water	20-24	matrix metallopeptidase 3	Homo sapiens	114-118
31490733-1	2019	Previously we have shown that increased expression of renal epithelial sodium channels (ENaC) may contribute to the renal sodium and water retention observed during chronic heart failure (CHF).	Water	133-138	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	88-92
31521813-4	2019	The inverse cubic phase with a 3D bicontinuous water channel enabled a 7-day sustained release of VEGF.	Water	47-52	vascular endothelial growth factor A	Homo sapiens	98-102
31521813-5	2019	The release profile of VEGF-LLC was controlled using octyl glucoside (OG) as a hydration-modulating agent, which could enlarge the water channel, yielding a 2-fold increase in water channel size and a 7-fold increase in VEGF release.	Water	131-136	vascular endothelial growth factor A	Homo sapiens	23-27
31521813-5	2019	The release profile of VEGF-LLC was controlled using octyl glucoside (OG) as a hydration-modulating agent, which could enlarge the water channel, yielding a 2-fold increase in water channel size and a 7-fold increase in VEGF release.	Water	176-181	vascular endothelial growth factor A	Homo sapiens	23-27
31656733-6	2019	H2O2 facilitates the regulation of different stress-responsive transcription factors (TFs) including NAC, Zinc finger, WRKY, ERF, MYB, DREB and bZIP as both upstream and downstream events during stress signalling.	Water	0-4	ETS2 repressor factor	Homo sapiens	125-128
31509013-3	2019	Two Epac isoforms, Epac1 and Epac2, are abundantly expressed in the renal epithelium, where they are thought to regulate water and electrolyte transport, particularly in the proximal tubule and collecting duct.	Water	121-126	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	4-8
31490733-11	2019	These findings suggest a critical role for renal nerves in the enhanced expression of ENaC and AQP2 and subsequent pathophysiology of renal sodium and water retention associated with CHF.	Water	151-156	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	86-90
31509013-3	2019	Two Epac isoforms, Epac1 and Epac2, are abundantly expressed in the renal epithelium, where they are thought to regulate water and electrolyte transport, particularly in the proximal tubule and collecting duct.	Water	121-126	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	19-24
31509013-5	2019	In this review, we aim to critically summarize current knowledge of Epac relevance for renal function and to discuss the applicability of Epac-based strategies in the regulation of systemic water-electrolyte homeostasis.	Water	190-195	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	138-142
31760925-1	2019	Terminal oxidases of aerobic respiratory chains catalyze the transfer of electrons from the respiratory substrate, cytochrome c or quinol, to O2 with the formation of two H2O molecules.	Water	171-174	cytochrome c, somatic	Homo sapiens	115-127
31505255-6	2019	This study also indicates the important role of CXCR7 molecule in maintaining CNS homeostasis by balancing M1/M2 microglia, A1/A2 astrocytes, long term potentiation/long term depression markers which ultimately ameliorates HMGB1 induced neurodegeneration, synaptic depression and memory loss (assessed by both radial arm maze and Morris water maze) in male mice model of dementia.	Water	337-342	atypical chemokine receptor 3	Mus musculus	48-53
31401302-7	2019	Results in the Morris water maze suggest that cognitive flexibility was reduced by the blocking of the IL-6 trans-signaling in young and old Tg2576 female mice.	Water	22-27	interleukin 6	Mus musculus	103-107
31253288-0	2019	Ferrocene-based nanoporous organic polymer as solid-phase extraction sorbent for the extraction of chlorophenols from tap water, tea drink and peach juice samples.	Water	122-127	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	118-121
31545999-1	2019	Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2), a reactive oxygen species, or the blockade of catalase (enzyme that degrades H2O2 into H2O and O2) with icv injection of 3-amino-1,2,4-triazole (ATZ) reduces the pressor effects of angiotensin II also injected icv.	Water	146-150	catalase	Rattus norvegicus	115-123
31220653-8	2019	Therefore, MGO-IL can potentially serve as an excellent adsorbent for the simultaneous separation and removal of As(III) and As(V) from water.	Water	136-141	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	125-130
31020463-2	2019	METHODS: Angiotensin II (Ang II) was conjugated with bovine serum albumin and compared with Ang II for competition binding to AT1 receptors, to stimulate aldosterone release from adrenocortical cells, to promote beta-arrestin binding to AT1 receptors, to promote calcium mobilization, and stimulate drinking of water and saline by rats.	Water	311-316	angiotensinogen	Rattus norvegicus	9-23
31020463-2	2019	METHODS: Angiotensin II (Ang II) was conjugated with bovine serum albumin and compared with Ang II for competition binding to AT1 receptors, to stimulate aldosterone release from adrenocortical cells, to promote beta-arrestin binding to AT1 receptors, to promote calcium mobilization, and stimulate drinking of water and saline by rats.	Water	311-316	angiotensinogen	Rattus norvegicus	25-31
31020463-5	2019	BSA-Ang II and Ang II stimulated water appetite equivalently but BSA-Ang II stimulated saline appetite more than Ang II.	Water	33-38	angiotensinogen	Rattus norvegicus	4-10
31020463-5	2019	BSA-Ang II and Ang II stimulated water appetite equivalently but BSA-Ang II stimulated saline appetite more than Ang II.	Water	33-38	angiotensinogen	Rattus norvegicus	15-21
31369910-4	2019	The mean concentrations of six typical PFAS measured in indoor dust and drinking water are in the range of 15.13-491.07 ng g-1 and 0.31-4.14 ng L-1, respectively.	Water	81-86	immunoglobulin kappa variable 1-16	Homo sapiens	144-147
31377330-5	2019	NH4+, Ca2+, NO3-, and SO42- were the dominant water-soluble inorganic ions, accounting for 79.2% of the total ions on average.	Water	46-51	NBL1, DAN family BMP antagonist	Homo sapiens	12-15
31350821-8	2019	CONCLUSIONS: We conclude that several ODT and ODF formulations can improve the "discretion" issue because they are taken without water, but they have similar pharmacokinetics to corresponding film-coated tablet formulations.	Water	129-134	outer dense fiber of sperm tails 1	Homo sapiens	46-49
31020463-5	2019	BSA-Ang II and Ang II stimulated water appetite equivalently but BSA-Ang II stimulated saline appetite more than Ang II.	Water	33-38	angiotensinogen	Rattus norvegicus	15-21
31020463-5	2019	BSA-Ang II and Ang II stimulated water appetite equivalently but BSA-Ang II stimulated saline appetite more than Ang II.	Water	33-38	angiotensinogen	Rattus norvegicus	15-21
31253288-2	2019	Then, a SPE method with Fc-NOP packed cartridge combined with HPLC-UV detection was developed to determine CPs in tap water, black tea drinks and peach juice samples.	Water	118-123	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	114-117
31545472-10	2019	It was found that CdM downregulated H2O2-stimulated 8-hydroxydeoxyguanosine and gamma-H2AX levels and decreased the expression of the senescence-associated proteins p21 and p16.	Water	36-40	cyclin dependent kinase inhibitor 2A	Homo sapiens	173-176
31415124-10	2019	In addition, the Emx1-Lgl1-/- mice displayed impaired behavioral performance in the Morris water maze and fear conditioning test.	Water	91-96	LLGL1 scribble cell polarity complex component	Mus musculus	22-26
31472212-7	2019	Hydrophobicity/hydrophilicity nature of CA/PCL mats was measured using water contact-angle method before and after treatment with NaOH.	Water	71-76	citrate synthase-like	Apis mellifera	40-46
31354067-1	2019	This work describes the preparation of bovine serum albumin (BSA) nanoparticles by one-step desolvation method using acetone/ethanol as precipitating agent, glutaraldehyde as crosslinking agent, sodium azide as a preservative and water as reaction media for chloroaluminium phthalocyanine (ClAlPc) incorporation for photodynamic therapy action.	Water	230-235	albumin	Homo sapiens	46-59
31520338-2	2019	Protonated aniline prototropic tautomerization and nucleophilic substitution (SN1) to produce phenol with traces of water in the IMMS cell are reported.	Water	116-121	solute carrier family 38 member 3	Homo sapiens	78-81
31279186-1	2019	Calcium nitrate (Ca(NO3)2) addition can be used to control the release of phosphorus from sediments, however it can also cause an increase in the concentration of nitrate-nitrogen (NO3--N) in the water column.	Water	196-201	NBL1, DAN family BMP antagonist	Homo sapiens	20-23
31605711-6	2019	RESULTS: H2O2 induced cell activity suppression, apoptosis and clear autophagy well at the concentration of 300 muM Rg1 attenuated H2O2-induced cell injury at the concentration of 200 muM that it elevated cell activity, attenuated apoptosis and autophagy and activated phosphatidylinositol 3 kinase (PI3K)/AMP-activated protein kinase (AKT) and AMP-activated protein kinase (AMPK) signal pathways.	Water	9-13	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	306-334
31605711-6	2019	RESULTS: H2O2 induced cell activity suppression, apoptosis and clear autophagy well at the concentration of 300 muM Rg1 attenuated H2O2-induced cell injury at the concentration of 200 muM that it elevated cell activity, attenuated apoptosis and autophagy and activated phosphatidylinositol 3 kinase (PI3K)/AMP-activated protein kinase (AKT) and AMP-activated protein kinase (AMPK) signal pathways.	Water	9-13	AKT serine/threonine kinase 1	Rattus norvegicus	336-339
31605711-6	2019	RESULTS: H2O2 induced cell activity suppression, apoptosis and clear autophagy well at the concentration of 300 muM Rg1 attenuated H2O2-induced cell injury at the concentration of 200 muM that it elevated cell activity, attenuated apoptosis and autophagy and activated phosphatidylinositol 3 kinase (PI3K)/AMP-activated protein kinase (AKT) and AMP-activated protein kinase (AMPK) signal pathways.	Water	9-13	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	345-373
31605711-6	2019	RESULTS: H2O2 induced cell activity suppression, apoptosis and clear autophagy well at the concentration of 300 muM Rg1 attenuated H2O2-induced cell injury at the concentration of 200 muM that it elevated cell activity, attenuated apoptosis and autophagy and activated phosphatidylinositol 3 kinase (PI3K)/AMP-activated protein kinase (AKT) and AMP-activated protein kinase (AMPK) signal pathways.	Water	9-13	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	375-379
31605711-6	2019	RESULTS: H2O2 induced cell activity suppression, apoptosis and clear autophagy well at the concentration of 300 muM Rg1 attenuated H2O2-induced cell injury at the concentration of 200 muM that it elevated cell activity, attenuated apoptosis and autophagy and activated phosphatidylinositol 3 kinase (PI3K)/AMP-activated protein kinase (AKT) and AMP-activated protein kinase (AMPK) signal pathways.	Water	131-135	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	306-334
31605711-6	2019	RESULTS: H2O2 induced cell activity suppression, apoptosis and clear autophagy well at the concentration of 300 muM Rg1 attenuated H2O2-induced cell injury at the concentration of 200 muM that it elevated cell activity, attenuated apoptosis and autophagy and activated phosphatidylinositol 3 kinase (PI3K)/AMP-activated protein kinase (AKT) and AMP-activated protein kinase (AMPK) signal pathways.	Water	131-135	AKT serine/threonine kinase 1	Rattus norvegicus	336-339
31605711-6	2019	RESULTS: H2O2 induced cell activity suppression, apoptosis and clear autophagy well at the concentration of 300 muM Rg1 attenuated H2O2-induced cell injury at the concentration of 200 muM that it elevated cell activity, attenuated apoptosis and autophagy and activated phosphatidylinositol 3 kinase (PI3K)/AMP-activated protein kinase (AKT) and AMP-activated protein kinase (AMPK) signal pathways.	Water	131-135	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	345-373
31605711-6	2019	RESULTS: H2O2 induced cell activity suppression, apoptosis and clear autophagy well at the concentration of 300 muM Rg1 attenuated H2O2-induced cell injury at the concentration of 200 muM that it elevated cell activity, attenuated apoptosis and autophagy and activated phosphatidylinositol 3 kinase (PI3K)/AMP-activated protein kinase (AKT) and AMP-activated protein kinase (AMPK) signal pathways.	Water	131-135	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	375-379
31577387-3	2019	The obtained HSA-CAT nanoreactors (NRs) show retained and well-protected enzyme stability in catalyzing the decomposition of H2 O2 and enable efficient labeling of therapeutic radionuclide iodine-131 (131 I).	Water	125-130	catalase	Mus musculus	17-20
31577387-5	2019	As the result, such HSA-CAT NRs upon tumor accumulation would significantly attenuate tumor hypoxia by decomposing endogenous H2 O2 produced by cancer cells to molecular oxygen, and thereby remarkably improve the therapeutic efficacy of radionuclide 131 I.	Water	126-131	catalase	Mus musculus	24-27
31279186-1	2019	Calcium nitrate (Ca(NO3)2) addition can be used to control the release of phosphorus from sediments, however it can also cause an increase in the concentration of nitrate-nitrogen (NO3--N) in the water column.	Water	196-201	NBL1, DAN family BMP antagonist	Homo sapiens	181-184
31279186-4	2019	The combined application of Ca(NO3)2 addition and AER capping could tremendously reduce the amount of soluble reactive phosphorus (SR-P) in the overlying water, with SR-P reduction rates of 75.9-98.7%.	Water	154-159	NBL1, DAN family BMP antagonist	Homo sapiens	31-34
31279186-7	2019	The amount of NO3--N in the overlying water under the action of the combined treatment method using Ca(NO3)2 and AER was much lower than that under the action of the single Ca(NO3)2 treatment during the early stage of sediment remediation.	Water	38-43	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
31279186-7	2019	The amount of NO3--N in the overlying water under the action of the combined treatment method using Ca(NO3)2 and AER was much lower than that under the action of the single Ca(NO3)2 treatment during the early stage of sediment remediation.	Water	38-43	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
31279186-7	2019	The amount of NO3--N in the overlying water under the action of the combined treatment method using Ca(NO3)2 and AER was much lower than that under the action of the single Ca(NO3)2 treatment during the early stage of sediment remediation.	Water	38-43	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
31635888-0	2019	Corrigendum to "Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1" [Toxicology 305 (2013) 10-19].	Water	33-37	caveolin 1	Homo sapiens	111-121
31357361-2	2019	The fluorescent probe was water-soluble and had a large Stokes shift of 150 nm, whose detection limit could reach to 0.96 muM in PBS buffer.	Water	26-31	latexin	Homo sapiens	122-125
31717830-0	2019	Renal Ca2+ and Water Handling in Response to Calcium Sensing Receptor Signaling: Physiopathological Aspects and Role of CaSR-Regulated microRNAs.	Water	15-20	calcium sensing receptor	Homo sapiens	45-69
31369749-2	2019	AVP is the primary hormone involved in water homeostasis.	Water	39-44	arginine vasopressin	Homo sapiens	0-3
31369749-6	2019	Functional components of the UT (eg, claudins and receptors or ion channels) play important roles in AVP-mediated water homeostasis.	Water	114-119	arginine vasopressin	Homo sapiens	101-104
31358226-9	2019	Finally, when further used to determine Cd(II) and Pb(II) in tap water and lake water, the results of fabricated electrode successfully achieve good consistency with the data obtained from inductively coupled plasma-mass spectrometry (ICP-MS).	Water	65-70	submaxillary gland androgen regulated protein 3B	Homo sapiens	51-57
32144232-0	2019	Enhanced removal of NO3-N from water using Fe-Al modified biochar: behavior and mechanism.	Water	31-36	NBL1, DAN family BMP antagonist	Homo sapiens	20-23
31781339-7	2019	In H2O2-treated DAergic neurons differentiated from PD-iPSCs, NC001-8 rescued the aberrant increase in ROS and cleaved caspase 3 by upregulating NRF2 and NQO1.	Water	3-7	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
31781339-7	2019	In H2O2-treated DAergic neurons differentiated from PD-iPSCs, NC001-8 rescued the aberrant increase in ROS and cleaved caspase 3 by upregulating NRF2 and NQO1.	Water	3-7	NAD(P)H quinone dehydrogenase 1	Homo sapiens	154-158
31717879-0	2019	Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1alpha-Mediated Metabolic Reprogramming.	Water	26-31	PPARG coactivator 1 alpha	Homo sapiens	65-75
31450289-8	2019	Moreover, the adsorbed protein (%) at the oil/water interface of SPI emulsions was higher than those of WPI and gelatin emulsions.	Water	46-51	chromogranin A	Bos taurus	65-68
31708788-5	2019	Our data demonstrated that NPY expression was significantly increased in MI rats and hypoxia/hydrogen peroxide (H2O2)-treated cardiomyocytes.	Water	112-116	neuropeptide Y	Rattus norvegicus	27-30
31492466-6	2019	The method was validated using spiked recoveries (100 ng L-1) from PFAS contaminated surface-water samples with recoveries ranging from 86% to 111% and relative standard deviations below 18%.	Water	93-98	immunoglobulin kappa variable 1-16	Homo sapiens	57-60
31708788-12	2019	Moreover, BIBO3304 and FoxO4 siRNA significantly increased the cell activity, inhibited the cell apoptosis, and decreased caspase-3 expression and activity in H2O2-treated cardiomyocytes that NPY presented the opposite effect.	Water	159-163	neuropeptide Y	Rattus norvegicus	192-195
31717879-5	2019	Thus, we evaluated the effects of balanced deep-sea water on lactate metabolism in C2C12 myotubes, and found that balanced deep-sea water mediated lactate metabolism by regulating the gene expression levels of lactate dehydrogenases A and B, a monocarboxylate transporter, and a mitochondrial pyruvate carrier.	Water	52-57	lactate dehydrogenase A	Homo sapiens	210-240
31717879-5	2019	Thus, we evaluated the effects of balanced deep-sea water on lactate metabolism in C2C12 myotubes, and found that balanced deep-sea water mediated lactate metabolism by regulating the gene expression levels of lactate dehydrogenases A and B, a monocarboxylate transporter, and a mitochondrial pyruvate carrier.	Water	132-137	lactate dehydrogenase A	Homo sapiens	210-240
31717879-6	2019	The activities of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and signaling molecules involved in PGC-1alpha activation were also upregulated by treatment with balanced deep-sea water.	Water	215-220	PPARG coactivator 1 alpha	Homo sapiens	18-85
31717879-6	2019	The activities of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and signaling molecules involved in PGC-1alpha activation were also upregulated by treatment with balanced deep-sea water.	Water	215-220	PPARG coactivator 1 alpha	Homo sapiens	87-97
31717879-6	2019	The activities of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and signaling molecules involved in PGC-1alpha activation were also upregulated by treatment with balanced deep-sea water.	Water	215-220	PPARG coactivator 1 alpha	Homo sapiens	135-145
31574221-0	2019	Relative Solvent Exposure of the Alpha-Helix and Beta-Sheet in Water Determines the Initial Stages of Urea and Guanidinium Chloride-Induced Denaturation of Alpha/Beta Proteins.	Water	63-68	amyloid beta precursor protein	Homo sapiens	156-166
31574221-4	2019	Here, we present a way to predict the possible unfolding route of alpha/beta proteins, in terms of secondary structure melting, based on the observation of relative solvent exposure of the alpha-helix and beta-sheet of protein in water.	Water	230-235	amyloid beta precursor protein	Homo sapiens	17-18
31574221-4	2019	Here, we present a way to predict the possible unfolding route of alpha/beta proteins, in terms of secondary structure melting, based on the observation of relative solvent exposure of the alpha-helix and beta-sheet of protein in water.	Water	230-235	amyloid beta precursor protein	Homo sapiens	66-76
31574221-8	2019	Urea- and GdmCl-induced initial unfolding pathways of the alpha/beta protein is thus determined by the relative solvent exposure of the alpha-helix and beta-sheet of protein in water.	Water	177-182	amyloid beta precursor protein	Homo sapiens	58-68
31574221-9	2019	Therefore, detailed knowledge of relative solvent exposures in water can provide a hint of the possible unfolding pathway provided the mode of action of the solvent is known.	Water	63-68	amyloid beta precursor protein	Homo sapiens	14-15
31708788-7	2019	Meanwhile, NPY small interfering RNA (siRNA) inhibited the cell apoptosis in H2O2-treated H9c2 cells and hypoxia-treated neonatal rat ventricular myocytes.	Water	77-81	neuropeptide Y	Rattus norvegicus	11-14
31708788-9	2019	Moreover, NPY type 1 receptor antagonist BIBO3304 can reverse miR-499 decrease and FoxO4 increase in H2O2-induced cardiomyocytes.	Water	101-105	neuropeptide Y	Rattus norvegicus	10-13
31708788-10	2019	NPY siRNA inhibited cell apoptosis in H2O2-treated H9c2 cells that were reversed by miR-499 inhibitor.	Water	38-42	neuropeptide Y	Rattus norvegicus	0-3
31527118-10	2019	Here we identified that the water accessibility around transmembrane domain 3 in presenilin 1 was increased along with a reduction in toxic amyloid-beta production.	Water	28-33	amyloid beta precursor protein	Homo sapiens	140-152
31772588-7	2019	H2O2 was used to induce apoptosis in HL-1 cardiomyocytes.	Water	0-4	asialoglycoprotein receptor 1	Homo sapiens	37-41
31772588-11	2019	hESC-NSC-derived MVs increased the autophagy and inhibited the apoptosis of HL-1 cells exposed to H2O2 for 3 h in a dose-dependent manner.	Water	98-102	asialoglycoprotein receptor 1	Homo sapiens	76-80
31635114-1	2019	A temperature, glutathione (GSH), and H2O2 multi-responsive composite nanocarrier (MSN-SS-Fc@beta-CD-PNIPAM) based on beta-cyclodextrin-poly(N-isopropylacrylamide) (beta-CD-PNIPAM) star polymer capped ferrocene modified mesoporous silica nanoparticles (MSN-SS-Fc) was successfully prepared.	Water	38-42	moesin	Homo sapiens	83-86
31491074-8	2019	Compound 6g also elicited noteworthy improvement in Abeta-induced cognitive dysfunctions in the Morris water maze test with downregulation in the expression of Abeta and BACE-1 proteins corroborated by Western blot and immunohistochemical analysis.	Water	103-108	amyloid beta precursor protein	Homo sapiens	52-57
31623611-13	2019	CONCLUSIONS: Drinking water nitrate significantly contributed to the endogenous formation of NOC, independent of the meat type consumed.	Water	22-27	nocturnin	Homo sapiens	93-96
31623611-14	2019	This implies that drinking water nitrate levels should be taken into account when evaluating the effect of meat consumption on endogenous formation of NOC.	Water	27-32	nocturnin	Homo sapiens	151-154
31713377-12	2019	Multivariate non-conditional logistic regression analysis showed that high education level, high coverage of harmless toilets, drinking tap water and deworming were protective factors for intestinal parasitic infections in children in Henan Province.	Water	140-145	SEC14 like lipid binding 2	Homo sapiens	136-139
31576860-0	2019	Lycopene alleviates H2O2-induced oxidative stress, inflammation and apoptosis in bovine mammary epithelial cells via the NFE2L2 signaling pathway.	Water	20-24	NFE2 like bZIP transcription factor 2	Bos taurus	121-127
31320072-0	2019	Structural studies of a water insoluble beta-glucan from Pleurotus djamor and its cytotoxic effect against PA1, ovarian carcinoma cells.	Water	24-29	PAXIP1 associated glutamate rich protein 1	Homo sapiens	107-110
31320072-4	2019	The water insoluble beta-glucan showed cytotoxic effect against PA1 cells, where~50% population was destroyed at 100 mug/mL concentration, and almost all cells at 250 mug/mL concentration.	Water	4-9	PAXIP1 associated glutamate rich protein 1	Homo sapiens	64-67
31482928-2	2019	Here we focus initially on the impact of increasing particle diameter (notionally 20 to 140 mum) on the ease of particle extraction from an advancing bed of charged particles beneath an earthed, suspended water droplet.	Water	205-210	latexin	Homo sapiens	92-95
31490511-5	2019	Each of the three technetium-99m labelled naphthalimide complexes were successfully produced from fac-[99mTc(CO)3(H2O)3]+ in 15 minutes at 70  C and isolated in radiochemical yields ranging from 60-95% with radiochemical purities greater than 95%.	Water	114-117	FA complementation group C	Homo sapiens	98-101
31545024-10	2019	The SOD activity has been also evaluated under catalytic conditions at pH 7.75, where the ratio between NiL3S(OH2)/ NiL3S(OH) is about (86:14), and a rate constant, kcat = 1.8 x 105 M-1 s-1, has been measured.	Water	110-113	superoxide dismutase 1	Homo sapiens	4-7
31495858-5	2019	The device could effectively homogenize DI water and fluorescein within a mixing length of 25.2 mum up to a flow rate of 116 muL min-1 at a driving voltage of 40 Vpp, corresponding to a mixing time of 0.8 ms.	Water	43-48	CD59 molecule (CD59 blood group)	Homo sapiens	129-134
31545024-11	2019	NiL3S(OH2) is thus the first low-molecular weight, synthetic, bioinspired Ni complex that displays catalytic SOD activity in water at physiological pH, although it does not contain any N-donor ligand in its first coordination sphere, as in the NiSOD.	Water	125-130	superoxide dismutase 1	Homo sapiens	109-112
31352502-9	2019	Method quantification limits were in the range from 1.0 to 33 ng L-1 in wastewater and from 0.5 to 28 ng L-1 in tap water.	Water	77-82	immunoglobulin kappa variable 1-16	Homo sapiens	65-68
31478667-3	2019	Free energies of solvation for Ag+ and NO3- were found to agree well with experimental values of -118.2 and -60.1 kcal/mol, respectively calculated using cluster- continuum models with six to eight water molecules and including solute relaxation and London D3 dispersive interactions.	Water	198-203	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
31487143-7	2019	Because of the noncovalent character of these interactions, immobilization is reversible and modified beta-CD surfaces can be recycled, which provides a positive outlook for their incorporation in water purification systems.	Water	197-202	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	102-109
31424613-0	2019	Targeting an EGFR Water Network with 4-Anilinoquin(az)oline Inhibitors for Chordoma.	Water	18-23	epidermal growth factor receptor	Homo sapiens	13-17
31632242-11	2019	Additionally, we also show that H2O2 (100 muM) produces a robust increase in Ca2+ entry in cell cultures which is enhanced by TNF-alpha via the TRPV1 channel and which involves ERK1/2 phosphorylation.	Water	32-36	tumor necrosis factor	Rattus norvegicus	126-135
31694516-2	2019	Prolactin is one of the most important regulators of salt and water balance.	Water	62-67	prolactin	Rattus norvegicus	0-9
31220425-8	2019	Similarly, fluid intake (water + 1.8% NaCl) also increased when rats receiving aldosterone infusion were treated with ANG II acutely into the LV.	Water	25-30	angiotensinogen	Rattus norvegicus	118-124
31176904-1	2019	Water-stable PVA/PAA nanofibers were fabricated through electrospinning and evaluated for their performance in lead (Pb(II)) and cadmium (Cd(II)) removal from water in a batch experiment.	Water	0-5	submaxillary gland androgen regulated protein 3B	Homo sapiens	117-123
31325882-5	2019	Water-soluble inorganic ions (SO42-, NO3-, and NH4+) accounted for ~52.2% of the PM2.5 mass, of which sulfate was dominant in wet haze periods while nitrate was dominant in other periods.	Water	0-5	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
31302397-2	2019	Its potential was tested for the removal of Ni (II) and Pb (II) ions from water.	Water	74-79	submaxillary gland androgen regulated protein 3B	Homo sapiens	44-63
31173958-10	2019	Therefore, NO3-N and TP migrated down with water infiltration in soil, and preventing NO3-N and P leaching was critical for effective N and P removal though rain gardens.	Water	43-48	NBL1, DAN family BMP antagonist	Homo sapiens	11-14
31330348-2	2019	Differences were observed between fog water and rain composition for most analyzed ions.	Water	38-43	zinc finger protein, FOG family member 1	Homo sapiens	34-37
31330348-3	2019	Ion abundance in fog water was Ca2+ > Cl- > Na+ > SO42- > Mg2+ > NH4+ >K+ > NO3- whereas an order of Ca2+ > Na+ > Cl- > Mg2+ > SO42- > NO3- > K+ > NH4+ was observed for rain water.	Water	21-26	zinc finger protein, FOG family member 1	Homo sapiens	17-20
31377929-3	2019	Twenty-six out of thirty-four PPCPs were detected, and the total concentrations of antibiotics ranged from 0.15 to 214.75 ng L-1 in surface water.	Water	140-145	immunoglobulin kappa variable 1-16	Homo sapiens	125-128
31330348-3	2019	Ion abundance in fog water was Ca2+ > Cl- > Na+ > SO42- > Mg2+ > NH4+ >K+ > NO3- whereas an order of Ca2+ > Na+ > Cl- > Mg2+ > SO42- > NO3- > K+ > NH4+ was observed for rain water.	Water	174-179	zinc finger protein, FOG family member 1	Homo sapiens	17-20
31330348-4	2019	All ion concentrations were higher in fog water than in rain water.	Water	42-47	zinc finger protein, FOG family member 1	Homo sapiens	38-41
31330348-7	2019	For trace elements, Al, As, Mn and Se were the most abundant elements in fog water; only Al and As were detected in rain water.	Water	77-82	zinc finger protein, FOG family member 1	Homo sapiens	73-76
31362025-0	2019	Analysis of hydration water around human serum albumin using near-infrared spectroscopy.	Water	22-27	albumin	Homo sapiens	41-54
31168059-8	2019	Although both aldosterone and NaCl water significantly decreased the running distance, tubulointerstitial damage involving interstitial infiltration of macrophages and fibrosis and the elevation of urinary human L-FABP induced by aldosterone injection was prevented by voluntary running exercise training.	Water	35-40	fatty acid binding protein 1	Homo sapiens	212-218
31362025-2	2019	To get a generalized picture of hydrogen bond network of water surrounding human serum albumin (HSA), near-infrared (NIR) spectroscopy was adopted to explore the hydration induced structural changes of water with HSA concentration from 0.015 to 0.746 mmol/L.	Water	57-62	albumin	Homo sapiens	81-94
31362025-2	2019	To get a generalized picture of hydrogen bond network of water surrounding human serum albumin (HSA), near-infrared (NIR) spectroscopy was adopted to explore the hydration induced structural changes of water with HSA concentration from 0.015 to 0.746 mmol/L.	Water	202-207	albumin	Homo sapiens	81-94
31255583-6	2019	Furthermore, albumin loss from the intravascular compartment reduces the osmotic potential of plasma to retain water.	Water	111-116	albumin	Homo sapiens	13-20
31509245-8	2019	The results of in vitro studies revealed a significant inhibition in the adhesion of monocytes to EA.hy926 cells stimulated by TNF-alpha in the subcritical water extract-treated group.	Water	156-161	tumor necrosis factor	Homo sapiens	127-136
31325498-1	2019	A phase inversion based cold water dilution method was developed to encapsulate Vitamin D3 (Vit D) in nano-structured lipid carrier (NLC) by blending caprylic-/capric triglyceride, Leciva S70 and Kolliphor HS 15, Vit D and sodium chloride.	Water	29-34	vitrin	Homo sapiens	80-83
31325498-1	2019	A phase inversion based cold water dilution method was developed to encapsulate Vitamin D3 (Vit D) in nano-structured lipid carrier (NLC) by blending caprylic-/capric triglyceride, Leciva S70 and Kolliphor HS 15, Vit D and sodium chloride.	Water	29-34	vitrin	Homo sapiens	92-95
31575764-3	2019	Generation of hydrogen peroxide (H2O2) by the dual oxidase (Duox) pathway is a critical component of the innate immune response, which functions to impede infection and maintain homeostatic regulation of the gut microbiota.	Water	33-37	Dual oxidase	Drosophila melanogaster	46-58
31119874-8	2019	After controlling for socio-economic position, Pakistani-origin mothers had lower chances of initiating and higher chances of stopping breastfeeding with increased water DBP exposure (e.g., OR for 0.03-0.61 vs. <0.02 mug/day dibromochloromethane exposure 0.70 [0.58-0.83], HR 1.16 [0.99-1.36]), greater air pollution exposure predicted lower chances of initiation for both ethnic groups (e.g., OR for 10 mug/m3 increase in nitrogen dioxide 0.81 [0.66-0.99] for White British mothers and 0.79 [0.67-0.94] for Pakistani-origin mothers) but also a reduced hazard of stopping breastfeeding for White British mothers (HR 0.65 [0.52-0.80]), and exposure to household damp/mould predicted higher chances of breastfeeding initiation amongst White British mothers (OR 1.66 [1.11-2.47]).	Water	164-169	D-box binding PAR bZIP transcription factor	Homo sapiens	170-173
31575764-3	2019	Generation of hydrogen peroxide (H2O2) by the dual oxidase (Duox) pathway is a critical component of the innate immune response, which functions to impede infection and maintain homeostatic regulation of the gut microbiota.	Water	33-37	Dual oxidase	Drosophila melanogaster	60-64
31575764-6	2019	The results demonstrated that exposure to sublethal imidacloprid reduced H2O2 production by inhibiting transcription of the Duox gene.	Water	73-77	Dual oxidase	Drosophila melanogaster	124-128
31650715-5	2019	Consistent with known properties of TRPM7 current, the current in adipocytes was activated by the elimination of extracellular divalent cations and the reduction of intracellular free Mg2+ concentrations, and was inhibited by the TRPM7 inhibitors, 2-aminoethyl diphenylborinate (2-APB), hydrogen peroxide (H2 O2 ), N-methyl maleimide (NMM), NS8593, and 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol (FTY720).	Water	306-311	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	36-41
31650715-5	2019	Consistent with known properties of TRPM7 current, the current in adipocytes was activated by the elimination of extracellular divalent cations and the reduction of intracellular free Mg2+ concentrations, and was inhibited by the TRPM7 inhibitors, 2-aminoethyl diphenylborinate (2-APB), hydrogen peroxide (H2 O2 ), N-methyl maleimide (NMM), NS8593, and 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol (FTY720).	Water	306-311	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	230-235
31226391-5	2019	The results indicated that fluoride concentration in drinking water ranged from 0.0 to 5.5 mg L-1 of the study area.	Water	62-67	immunoglobulin kappa variable 1-16	Homo sapiens	94-97
31178160-9	2019	Overall, the observed and much faster dewetting of water from C8 column than that from C18 column is primarily explained by a higher internal pore connectivity due to the thinner thickness of the alkyl-bonded layer (7 A versus 15 A) and, to a lesser extent, by a higher extrusion Laplace pressure of water ( +10 bar).	Water	51-56	Bardet-Biedl syndrome 9	Homo sapiens	87-90
31616834-2	2019	Herein, we report the first examples of mononuclear cyclometallated iridium(III) complexes incorporating phosphonate ligands, namely, [Ir(ppy)2(HL1)] 0.5H2O (1), [Ir(ppy)2(HL2)] 0.5H2O (2), [Ir(dfppy)2(HL1)] (3), and [Ir(dfppy)2(HL2)] 3.5H2O (4) (ppy = 2-phenylpyridine, dfppy = 2-(2,4-difluorophenyl)pyridine, H2L1 = 2-pyridylphosphonic acid, H2L2 = 2-quinolinephosphonic acid).	Water	152-156	asialoglycoprotein receptor 1	Homo sapiens	144-147
31178160-0	2019	Faster dewetting of water from C8- than from C18-bonded silica particles used in reversed-phase liquid chromatography: Solving the paradox.	Water	20-25	Bardet-Biedl syndrome 9	Homo sapiens	45-48
31562333-3	2019	While H2O2 exposure substantially decreases cell proliferation and increases p53, p21, p16, and p19 in cells from mice and rats, cells from spiny mice and rabbits are highly resistant to H2O2.	Water	6-10	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	87-90
31513398-0	2019	Role of the Solvation Water in Remote Interactions of Hyperactive Antifreeze Proteins with the Surface of Ice.	Water	22-27	carboxylesterase 2	Homo sapiens	106-109
31513398-4	2019	It acts at early stages of adsorption, prior to the solidification of water between the ice and the protein molecule nearby.	Water	70-75	carboxylesterase 2	Homo sapiens	88-91
31513398-5	2019	We propose the water-originating mechanism of the generation of this force and also the mechanism of remote attachment of an antifreeze molecule to the ice surface.	Water	15-20	carboxylesterase 2	Homo sapiens	152-155
31557847-5	2019	Interestingly, by investigating the LT-e/w mechanism of action, it was found that LT-e/w extract decreases the levels of H2O2-provoked reactive oxidative species (ROS) accumulation, mitochondrial depolarization, phosphatidylserine externalization, caspase-3/7 activation, and poly (ADP-ribose) polymerase (PARP) cleavage significantly, which are hallmarks of apoptosis.	Water	121-125	poly(ADP-ribose) polymerase 1	Homo sapiens	248-304
31557847-5	2019	Interestingly, by investigating the LT-e/w mechanism of action, it was found that LT-e/w extract decreases the levels of H2O2-provoked reactive oxidative species (ROS) accumulation, mitochondrial depolarization, phosphatidylserine externalization, caspase-3/7 activation, and poly (ADP-ribose) polymerase (PARP) cleavage significantly, which are hallmarks of apoptosis.	Water	121-125	poly(ADP-ribose) polymerase 1	Homo sapiens	306-310
31616834-2	2019	Herein, we report the first examples of mononuclear cyclometallated iridium(III) complexes incorporating phosphonate ligands, namely, [Ir(ppy)2(HL1)] 0.5H2O (1), [Ir(ppy)2(HL2)] 0.5H2O (2), [Ir(dfppy)2(HL1)] (3), and [Ir(dfppy)2(HL2)] 3.5H2O (4) (ppy = 2-phenylpyridine, dfppy = 2-(2,4-difluorophenyl)pyridine, H2L1 = 2-pyridylphosphonic acid, H2L2 = 2-quinolinephosphonic acid).	Water	152-156	asialoglycoprotein receptor 1	Homo sapiens	202-205
31616834-2	2019	Herein, we report the first examples of mononuclear cyclometallated iridium(III) complexes incorporating phosphonate ligands, namely, [Ir(ppy)2(HL1)] 0.5H2O (1), [Ir(ppy)2(HL2)] 0.5H2O (2), [Ir(dfppy)2(HL1)] (3), and [Ir(dfppy)2(HL2)] 3.5H2O (4) (ppy = 2-phenylpyridine, dfppy = 2-(2,4-difluorophenyl)pyridine, H2L1 = 2-pyridylphosphonic acid, H2L2 = 2-quinolinephosphonic acid).	Water	180-188	asialoglycoprotein receptor 1	Homo sapiens	144-147
31616834-2	2019	Herein, we report the first examples of mononuclear cyclometallated iridium(III) complexes incorporating phosphonate ligands, namely, [Ir(ppy)2(HL1)] 0.5H2O (1), [Ir(ppy)2(HL2)] 0.5H2O (2), [Ir(dfppy)2(HL1)] (3), and [Ir(dfppy)2(HL2)] 3.5H2O (4) (ppy = 2-phenylpyridine, dfppy = 2-(2,4-difluorophenyl)pyridine, H2L1 = 2-pyridylphosphonic acid, H2L2 = 2-quinolinephosphonic acid).	Water	237-245	asialoglycoprotein receptor 1	Homo sapiens	144-147
31309671-2	2019	Our experiments and density functional theory (DFT) calculations show the 3D p-FGDY/CC network is highly active and it is a high potential metal-free catalyst for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER), as well as overall water splitting (OWS) under both acidic and alkaline conditions.	Water	257-262	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	79-83
31551334-8	2019	In vitro, Php1 enzymatic activity was resistant to the effects of the streptococcal secreted metabolites pABA and H2O2, which inhibited Ltp1, an enzyme in the low-molecular-weight (LMW) phosphotyrosine phosphatase family.	Water	114-118	phospholipid phosphatase related 4	Homo sapiens	10-14
31662774-5	2019	Furthermore, MSAE suppressed expression levels of H2O2-induced apoptotic genes such as cleaved caspase-3, caspase-9, and cleaved poly (ADP-ribose) polymerase (PARP).	Water	50-54	caspase 3	Homo sapiens	95-104
31662774-5	2019	Furthermore, MSAE suppressed expression levels of H2O2-induced apoptotic genes such as cleaved caspase-3, caspase-9, and cleaved poly (ADP-ribose) polymerase (PARP).	Water	50-54	poly(ADP-ribose) polymerase 1	Homo sapiens	129-157
31662774-5	2019	Furthermore, MSAE suppressed expression levels of H2O2-induced apoptotic genes such as cleaved caspase-3, caspase-9, and cleaved poly (ADP-ribose) polymerase (PARP).	Water	50-54	poly(ADP-ribose) polymerase 1	Homo sapiens	159-163
31662774-6	2019	Pretreatment with MSAE induced expression of phase II enzyme such as HO-1 through translocation of NF-E2-related factor (Nrf2) upon H2O2 exposure.	Water	132-136	NFE2 like bZIP transcription factor 2	Homo sapiens	121-125
31541125-8	2019	Furthermore, the production of IL6 induced by H2O2 was suppressed by the THGP treatment.	Water	46-50	interleukin 6	Homo sapiens	31-34
31533751-1	2019	BACKGROUND: This study aimed to assess the efficacy of water-filtered infrared A (wIRA) in sacroiliitis in male patients with ankylosing spondylitis (AS) and the effect of wIRA therapy on serum vascular endothelial growth factor (VEGF).	Water	55-60	vascular endothelial growth factor A	Homo sapiens	194-228
31541178-1	2019	beta-CD-DPPE molecule was synthesized through the conjugation of beta-CD-NH2 and the DPPE molecule, and its" water-solubility was more excellent than the traditional phospholipid molecule.	Water	109-114	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	0-7
31429271-2	2019	Most of the reported works of fog collection focus on the water-collecting ability rather than the environmental reliability of selected materials.	Water	58-63	zinc finger protein, FOG family member 1	Homo sapiens	30-33
31429271-5	2019	Due to its strong affinity to water molecules, the tilted needles with a CB coating can facilitate the capture of fog and the rapid delivery of condensed water driven by gravity.	Water	30-35	zinc finger protein, FOG family member 1	Homo sapiens	114-117
31533751-1	2019	BACKGROUND: This study aimed to assess the efficacy of water-filtered infrared A (wIRA) in sacroiliitis in male patients with ankylosing spondylitis (AS) and the effect of wIRA therapy on serum vascular endothelial growth factor (VEGF).	Water	55-60	vascular endothelial growth factor A	Homo sapiens	230-234
31527532-0	2019	The Hardness of Drinking Water Negatively while Socio-Economic Deprivation Positively Correlate with the Age-Adjusted Mortality Rates due to Cardiovascular Diseases in Hungarian Wine Regions.	Water	25-30	renin binding protein	Homo sapiens	105-108
31026749-2	2019	Considering the Km/w value is difficult to observe experimentally for real biological membranes, liposome/water partition coefficient (Klip/w) is employed to approximate Km/w.	Water	106-111	TNFAIP3 interacting protein 2	Homo sapiens	135-139
31284012-8	2019	The results show that APTS-Fe3O4/APT@CS is a promising hybrid adsorbent for effective removal of Pb(II) from water.	Water	109-114	submaxillary gland androgen regulated protein 3B	Homo sapiens	97-103
31160095-5	2019	A sheath liquid composed of isopropanol - water - acetic acid with a flow rate of 10 muL min-1 and mild MS conditions allowed optimal signal intensities.	Water	42-47	CD59 molecule (CD59 blood group)	Homo sapiens	89-94
31411472-1	2019	Human aquaporin 1 (hAQP1) is the first discovered selective water channel present in lipid membranes of multiple types of cells.	Water	60-65	aquaporin 1 (Colton blood group)	Homo sapiens	6-17
31411472-1	2019	Human aquaporin 1 (hAQP1) is the first discovered selective water channel present in lipid membranes of multiple types of cells.	Water	60-65	aquaporin 1 (Colton blood group)	Homo sapiens	19-24
31411472-2	2019	Several structures of hAQP1 and its bovine homolog have been obtained by electron microscopy and X-ray crystallography, giving a consistent picture of the transmembrane domain with the water-conducting pore.	Water	185-190	aquaporin 1 (Colton blood group)	Homo sapiens	22-27
31506286-5	2019	Superoxide dismutase 2 (SOD2) is a mitochondrial-specific antioxidant enzyme that dismutates superoxide to hydrogen peroxide, which is then converted to water by catalase and glutathione peroxidase.	Water	153-158	catalase	Homo sapiens	162-170
33163543-5	2019	Abiotic methylation was further verified in natural river water, and the yield of TBBPA MME mediated abiotically by CH3I was much greater than that of biotic methylation.	Water	58-63	membrane metalloendopeptidase	Homo sapiens	88-91
31423791-2	2019	An ene-reductase (OYE)-mediated selective hydrogenation of cinnamaldehyde to hydrocinnamaldehyde is followed by a regioselective Baeyer-Villiger oxidation (BVMO) to produce the corresponding formate ester that either spontaneously hydrolyzes to 2-phenylethanol in water or is assisted by a formate dehydrogenase (FDH).	Water	264-269	aldehyde dehydrogenase 1 family member L1	Homo sapiens	290-311
31423791-2	2019	An ene-reductase (OYE)-mediated selective hydrogenation of cinnamaldehyde to hydrocinnamaldehyde is followed by a regioselective Baeyer-Villiger oxidation (BVMO) to produce the corresponding formate ester that either spontaneously hydrolyzes to 2-phenylethanol in water or is assisted by a formate dehydrogenase (FDH).	Water	264-269	aldehyde dehydrogenase 1 family member L1	Homo sapiens	313-316
31173986-4	2019	OD-Pb(II) could disperse steadily in water even at pH &gt; 7.0.	Water	37-42	submaxillary gland androgen regulated protein 3B	Homo sapiens	3-9
31491983-9	2019	The experimental results showed that volumetric water contents compensated by ground temperature showed good agreement with the volumetric water contents estimated from the gravimetric water contents of the soil samples and TPI.	Water	48-53	triosephosphate isomerase 1	Homo sapiens	224-227
31491983-9	2019	The experimental results showed that volumetric water contents compensated by ground temperature showed good agreement with the volumetric water contents estimated from the gravimetric water contents of the soil samples and TPI.	Water	139-144	triosephosphate isomerase 1	Homo sapiens	224-227
31491983-9	2019	The experimental results showed that volumetric water contents compensated by ground temperature showed good agreement with the volumetric water contents estimated from the gravimetric water contents of the soil samples and TPI.	Water	139-144	triosephosphate isomerase 1	Homo sapiens	224-227
31487855-6	2019	In addition, water activity modulation and the protein loop motions suggest that GH1 beta-Glucosidases present an active site more adapted to glucose withdrawal than GH3, in consonance with the GH1s lower product inhibition.	Water	13-18	growth hormone 1	Homo sapiens	81-84
31641423-10	2019	HK-2 cells with SGK1 inhibition were much more sensitive to H2O2-induced oxidative stress injury than control group cells, as they exhibited increased apoptotic cell death and mitochondrial dysfunction involving the deterioration of cellular ATP production, ROS accumulation, mitochondrial membrane potential reduction, and release of Cytochrome C into the cytoplasm.	Water	60-64	cytochrome c, somatic	Homo sapiens	335-347
31551758-6	2019	Importantly, knockdown of appoptosin can ameliorate H2O2-induced JNK activation and apoptosis in primary neurons.	Water	52-56	mitogen-activated protein kinase 8	Homo sapiens	65-68
31479418-3	2019	MPTP significantly decreased dopamine transporter (DAT) immunoreactivity in the striatum and tyrosine hydroxylase (TH) immunoreactivity in the substantia nigra of water-treated mice.	Water	163-168	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	29-49
31477017-8	2019	A transcriptome analysis of the TPPF-overexpressing plants revealed that the expression levels of drought-repressed genes involved in electron transport activity and cell wall modification were upregulated, while those of stress-related transcription factors related to water deprivation were downregulated.	Water	270-275	Haloacid dehalogenase-like hydrolase (HAD) superfamily protein	Arabidopsis thaliana	32-36
31560767-2	2019	Aquaporin 0 (AQP0), in addition to its role in water transport in the lens, acts as a cell-cell adhesion molecule.	Water	47-52	major intrinsic protein of lens fiber	Mus musculus	0-11
31560767-2	2019	Aquaporin 0 (AQP0), in addition to its role in water transport in the lens, acts as a cell-cell adhesion molecule.	Water	47-52	major intrinsic protein of lens fiber	Mus musculus	13-17
31473924-6	2019	The springs that have NO3- concentrations of &gt; 30 mg/L are concentrated in residential and agricultural areas, suggesting that NO3- in spring water are mainly derived from chemical fertilizers, manure, and sewage.	Water	145-150	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
31473924-6	2019	The springs that have NO3- concentrations of &gt; 30 mg/L are concentrated in residential and agricultural areas, suggesting that NO3- in spring water are mainly derived from chemical fertilizers, manure, and sewage.	Water	145-150	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
31477744-1	2019	Aquaporin-1 (AQP1) has been proposed as a dual water and cation channel that when upregulated in cancers enhances cell migration rates; however, the mechanism remains unknown.	Water	47-52	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
31477744-1	2019	Aquaporin-1 (AQP1) has been proposed as a dual water and cation channel that when upregulated in cancers enhances cell migration rates; however, the mechanism remains unknown.	Water	47-52	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
29984872-4	2019	In the two-bottle free choice paradigm, GAL3 -KO mice consistently showed a significantly increased preference for ethanol over water when compared to wildtype littermates.	Water	128-133	lectin, galactose binding, soluble 3	Mus musculus	40-44
29984872-7	2019	In contrast to ethanol, GAL3 -KO mice exhibited similar preference for saccharin and sucrose over water, and a similar preference for a high fat diet over a low fat diet as wildtype littermates.	Water	98-103	lectin, galactose binding, soluble 3	Mus musculus	24-28
31477744-2	2019	Previous work identified AqB011 as an inhibitor of the gated human AQP1 cation conductance, and bacopaside II as a blocker of AQP1 water pores.	Water	131-136	aquaporin 1 (Colton blood group)	Homo sapiens	126-130
31477744-13	2019	Results here are the first to demonstrate that combined block of the AQP1 ion channel and water pores is more potent in impairing motility across diverse classes of colon cancer cells than single agents alone.	Water	90-95	aquaporin 1 (Colton blood group)	Homo sapiens	69-73
31050198-9	2019	Next, siRNA-mediated depletion of HNF1 revealed a pivotal role for this TF in coordinating epithelial water and solute transport in caput epithelium.	Water	102-107	HNF1 homeobox A	Homo sapiens	34-38
31251110-2	2019	Water channel aquaporin-1 (AQP1) enhances water flux across cell membranes, which is highly expressed and associated with cell migration, metastasis and angiogenesis in some human cancers.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	27-31
31251110-2	2019	Water channel aquaporin-1 (AQP1) enhances water flux across cell membranes, which is highly expressed and associated with cell migration, metastasis and angiogenesis in some human cancers.	Water	42-47	aquaporin 1 (Colton blood group)	Homo sapiens	27-31
31158658-2	2019	This study investigated the relationships between PCB concentrations in sediment pore water, humin electron transfer capacity, and potential PCB dechlorinators at eight sediment sampling sites in the southern Yellow Sea, China, with differential PCB contamination.	Water	86-91	pyruvate carboxylase	Homo sapiens	50-53
31102870-3	2019	GO/MCU-C3N4/PVDF composite membrane exhibited higher permeation flux than that of GO/PVDF membrane and exhibited excellent separation performance for oil-in-water emulsion.	Water	157-162	mitochondrial calcium uniporter	Homo sapiens	3-6
31176116-7	2019	The synthesis in the buffer allows reaching the high loading efficiency of 93%, high SOD content (24 versus 15 w/w % for the synthesis in water), and order of magnitude higher activity compared to the synthesis in water.	Water	138-143	superoxide dismutase 1	Homo sapiens	85-88
31176116-11	2019	The latest process contributes more in case of the co-synthesis in the buffer because at higher pH (co-synthesis in water) the unfolded SOD molecules aggregate stronger.	Water	116-121	superoxide dismutase 1	Homo sapiens	136-139
31252130-6	2019	The flood period showed significantly higher REG and Upot values than those of the normal period (p &lt; 0.05), probably controlled by higher water temperature and algal biomass.	Water	142-147	regenerating family member 1 alpha	Homo sapiens	45-48
31254364-0	2019	MEF2C/miR-133a-3p.1 circuit-stabilized AQP1 expression maintains endothelial water homeostasis.	Water	77-82	aquaporin 1 (Colton blood group)	Homo sapiens	39-43
31565882-1	2019	BACKGROUND: Striatin and caveolin-1 (cav-1) are scaffolding/regulating proteins that are associated with salt-sensitive high blood pressure and promote renal sodium and water reabsorption, respectively.	Water	169-174	caveolin 1	Rattus norvegicus	25-35
31565882-1	2019	BACKGROUND: Striatin and caveolin-1 (cav-1) are scaffolding/regulating proteins that are associated with salt-sensitive high blood pressure and promote renal sodium and water reabsorption, respectively.	Water	169-174	caveolin 1	Rattus norvegicus	37-42
31280960-5	2019	INTERVENTIONS: The "water injection"-assisted laparoscopic excision of ovarian endometrioma consists of five steps: rupture the ovarian endometrial cyst and remove the "chocolate fluid;" inject the "water" (diluted vasopressin solution) into the interface between endometrioma and ovarian parenchyma; stop injecting until the solution overflow; separate the endometrioma away from the ovarian parenchyma; and suture the ovary.	Water	20-25	arginine vasopressin	Homo sapiens	215-226
31254364-2	2019	However, how AQP1 level is stabilized to maintain endothelial water homeostasis is still not clear.	Water	62-67	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
31201908-7	2019	Experimentally, P(DADMAC-AAm)CMC/Fe2O3 and P(DADMAC-SA)CMC/Fe2O3 show high sorption capacity of Co(II), i.e. 69.67 mg g-1 and 75.17 mg g-1, respectively, which makes them potential sorbents for Co(II) removal from water/wastewater.	Water	214-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
31778539-5	2019	The resulting activation energy of 29 kJ mol-1 supports the hypothesis that water exchange is facilitated by water channels-aquaporins.	Water	76-81	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	41-46
31778539-5	2019	The resulting activation energy of 29 kJ mol-1 supports the hypothesis that water exchange is facilitated by water channels-aquaporins.	Water	109-114	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	41-46
32189984-3	2019	In acute toxicity test, 4 groups of rats (n = 6/group: 3 males and 3 females) were chosen and the first control group received tap water, while the other three groups received Av seed ethanolic extract dissolved in tap water at doses of 150, 300, and 600 mg/kg, and general behavior, adverse effects, and mortality were recorded for up to 14 days.	Water	219-224	nuclear RNA export factor 1	Rattus norvegicus	215-218
31228813-10	2019	miR-21-5p may also participate in the progress of EAU by affecting Th17/Treg balance via the regulation of IL-10.	Water	50-53	interleukin 10	Mus musculus	107-112
31163378-6	2019	Further, the toxicity of the treated water was assessed with the nematode Caenorhabditis elegans species at different time intervals by observing the expressions of important stress-responsive genes viz., sod-3, hsp-16.2, ctl-1,2,3 and gst-4.	Water	37-42	Glutathione S-transferase 4	Caenorhabditis elegans	236-241
31078097-0	2019	Influence of fulvic acid on Pb(II) removal from water using a post-synthetically modified MIL-100(Fe).	Water	48-53	submaxillary gland androgen regulated protein 3B	Homo sapiens	28-34
31078097-6	2019	FINDINGS: ED-MIL-100(Fe) enabled 99% removal of Pb(II) from water at or below 60 mg L-1, whereas the MIL-100(Fe) hardly adsorbed any Pb(II).	Water	60-65	submaxillary gland androgen regulated protein 3B	Homo sapiens	48-54
31212064-6	2019	In contrast, dosing the antioxidants in the tap water (i.e., before the heat exposure and rehydration with fructose) preserved renal function, prevented renal tubule dysfunction and avoided the increase in systemic blood pressure.	Water	48-53	nuclear RNA export factor 1	Rattus norvegicus	44-47
31300862-1	2019	The tight spatial and temporal organisation of cyclic adenosine monophosphate (cAMP) signalling plays a key role in arginine-vasopressin (AVP)-mediated water reabsorption in renal collecting duct principal cells and in a plethora of other processes such as in the control of cardiac myocyte contractility.	Water	152-157	arginine vasopressin	Homo sapiens	116-136
30561864-2	2019	For this, a well-defined water-soluble beta-CD-core star mPEG with aldehyde groups (CD-star(ald)PEG, III) is first designed and synthesized via the copper-catalyzed azide-alkyne click reaction.	Water	25-30	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	39-46
31300862-1	2019	The tight spatial and temporal organisation of cyclic adenosine monophosphate (cAMP) signalling plays a key role in arginine-vasopressin (AVP)-mediated water reabsorption in renal collecting duct principal cells and in a plethora of other processes such as in the control of cardiac myocyte contractility.	Water	152-157	arginine vasopressin	Homo sapiens	138-141
31300862-5	2019	Examples illustrate how screening for small molecules can pave the way to novel approaches for the treatment of certain forms of diabetes insipidus, a disease caused by defects in AVP-mediated water reabsorption.	Water	193-198	arginine vasopressin	Homo sapiens	180-183
31750822-15	2019	Conclusion TSA attenuates H2O2-induced endothelial cell senescence by activating SIRT1/eNOS signaling pathway.	Water	26-30	nitric oxide synthase 3	Homo sapiens	87-91
31319167-2	2019	Silencing of CA2 neurons in mice impairs social memory, and mice lacking Regulator of G-Protein Signaling 14 (RGS14), a protein that is highly enriched in CA2 neurons, learn faster than wild types in the Morris water maze spatial memory test.	Water	211-216	regulator of G-protein signaling 14	Mus musculus	73-108
31319167-2	2019	Silencing of CA2 neurons in mice impairs social memory, and mice lacking Regulator of G-Protein Signaling 14 (RGS14), a protein that is highly enriched in CA2 neurons, learn faster than wild types in the Morris water maze spatial memory test.	Water	211-216	regulator of G-protein signaling 14	Mus musculus	110-115
31319167-2	2019	Silencing of CA2 neurons in mice impairs social memory, and mice lacking Regulator of G-Protein Signaling 14 (RGS14), a protein that is highly enriched in CA2 neurons, learn faster than wild types in the Morris water maze spatial memory test.	Water	211-216	carbonic anhydrase 2	Mus musculus	155-158
31171194-3	2019	In this study, miR-141, which is used to diagnose several types of cancer, was detected in water and serum samples using a biosensor designed based on streptavidin-coated magnetic beads (SMBs), complementary sequences of miR-141 and PicoGreen as the fluorescent dye.	Water	91-96	microRNA 141	Homo sapiens	15-22
31171194-9	2019	The results revealed that the detection limits of the biosensor for miR-141 were 70 and 113.8 nmol L-1 in deionized water and serum samples, respectively.	Water	116-121	microRNA 141	Homo sapiens	68-75
31072474-1	2019	In this work, water-soluble pillar[6]arene functionalized PdPt porous core-shell octahedral nanodendrites (WP6@PdPt PCONs) were simply synthesized and used for the fabrication of NSE immunosensor.	Water	14-19	enolase 2	Homo sapiens	179-182
31072474-0	2019	Water-soluble pillar[6]arene functionalized PdPt porous core-shell octahedral nanodendrites to construct highly sensitive and robust neuron-specific enolase immunosensor by host-guest chemistry assisted catalytic amplification.	Water	0-5	enolase 2	Homo sapiens	133-156
31466332-3	2019	Test results indicate that water demand increases as the ash content increases, and the mechanical properties decrease slightly with an increase of the ash content until 30% of replacement.	Water	27-32	arylsulfatase family member H	Homo sapiens	57-60
31378752-5	2019	Scanning electron microscopy and atomic force microscopy were used to observe the surfaces of blocks after air abrasion and indicated that blocks absorbed water in air with elapsed time, which affected TBS between CAD/CAM composite resin blocks and luting agents.	Water	155-160	calmodulin 3	Homo sapiens	218-221
31364628-7	2019	For the water-water interaction different water force fields, i.e. SPCE, TIP3P, TIP4P, TIP4P/ICE, and TIP5P, are used.	Water	8-13	caspase 1	Homo sapiens	87-96
31324450-6	2019	Indeed, mutating the water-pocket residues of Argonaute2 and Argonaute4 compromised RISC assembly.	Water	21-26	argonaute RISC catalytic component 2	Homo sapiens	46-56
31461951-6	2019	Moreover, pretreatment with an inhibitor against NF-kappaB attenuates alterations in brain water content, pathological indications notable in brain edema, as well as mRNA and protein expression on levels of MMP-9, VCAM-1, ICAM-1, iNOS, and IL-1beta, tight junction proteins (TJs), GFAP and Iba-1 in the brain of 1,2-DCE-intoxicated mice.	Water	91-96	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-58
31508546-4	2019	The synthesized FLA-Pd displayed high activity for phosphine-free C(sp2)-C(sp2) coupling in water, and the catalyst could be reused for seven successive cycles.	Water	92-97	Sp2 transcription factor	Homo sapiens	66-71
31282659-7	2019	In the MDM2 case, the higher affinity of MIP is ascribed to a larger gain of translational, configurational entropy of water upon binding.	Water	119-124	major intrinsic protein of lens fiber	Homo sapiens	41-44
31398032-4	2019	The compounds have a novel ATAD2 binding mode with noncanonical features including the displacement of all conserved water molecules within the active site and a halogen-bonding interaction.	Water	117-122	ATPase family AAA domain containing 2	Homo sapiens	27-32
31273983-3	2019	In the presence of human serum albumin (HSA), a water-soluble protein, the aggregation states were resolved and formed a binding complex between P(V)porphyrin and HSA.	Water	48-53	albumin	Homo sapiens	25-38
31340641-0	2019	Specific and Quantitative Detection of Albumin in Biological Fluids by Tetrazolate-Functionalized Water-Soluble AIEgens.	Water	98-103	albumin	Homo sapiens	39-46
31340641-3	2019	Herein, a class of water-soluble tetrazolate-functionalized derivatives with aggregation-induced emission (AIE) characteristics is introduced as novel fluorescent probes for albumin detection.	Water	19-24	albumin	Homo sapiens	174-181
31391299-2	2019	In the second last transition (S2 to S3) cofactor oxidation is coupled to water molecule binding to Mn1.	Water	74-79	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	100-103
31273983-3	2019	In the presence of human serum albumin (HSA), a water-soluble protein, the aggregation states were resolved and formed a binding complex between P(V)porphyrin and HSA.	Water	48-53	albumin	Homo sapiens	40-43
31273983-3	2019	In the presence of human serum albumin (HSA), a water-soluble protein, the aggregation states were resolved and formed a binding complex between P(V)porphyrin and HSA.	Water	48-53	albumin	Homo sapiens	163-166
31170414-8	2019	RESULTS: We found that a low-dose exposure (0.25 ppm iAs in drinking water) caused glucose intolerance in adult male C57BL/6 mice, likely by disrupting glucose-induced insulin secretion without affecting peripheral insulin sensitivity.	Water	69-74	insulin	Homo sapiens	168-175
31314534-3	2019	In this study, we calculate these progressions in HCO2- (H2O), NO3- (H2O), and CS2- (H2O) by use of a one-dimensional adiabatic model with rock potentials generated from ab initio energies and frequencies.	Water	69-72	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
31314534-3	2019	In this study, we calculate these progressions in HCO2- (H2O), NO3- (H2O), and CS2- (H2O) by use of a one-dimensional adiabatic model with rock potentials generated from ab initio energies and frequencies.	Water	69-72	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
31154038-10	2019	The novel functionalized hordein/MBA/beta-CD nanofiber membranes have great potential in the application of water treatment.	Water	108-113	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	37-44
31229531-8	2019	Plasma treatment was able to significantly enhance water absorption to otherwise hydrophobic PCL/CAM matrix and had tremendous impact on its drug release kinetics as the drug was instantly released from otherwise prolonged release formulation.	Water	51-56	calmodulin 3	Homo sapiens	97-100
31411615-3	2019	Layer-by-layer deposition of polyelectrolyte poly(vinyl benzyl tetramethylammonium) chloride (p(VBTMA)Cl) and a tetrasulfonate water-soluble low molecular weight fluorophore (1) based on spirobifluorene leads to modified glass and quartz substrates with outstanding photophysical properties in response to bovine serum albumin (BSA).	Water	127-132	albumin	Homo sapiens	313-326
31497710-0	2019	Efficient Removal of Pb(II) and Cd(II) from Industrial Mine Water by a Hierarchical MoS2/SH-MWCNT Nanocomposite.	Water	60-65	submaxillary gland androgen regulated protein 3B	Homo sapiens	21-38
31516844-2	2019	The  14 PCB concentrations in the transformer oils, drainage water, groundwater and soils ranged from 484 to 48506 mg kg-1, 0.99 to 2.95 mg L-1, 0.16 to 0.56 mg L-1 and from 8.4 to 510 mg kg-1 respectively.	Water	61-66	pyruvate carboxylase	Homo sapiens	8-11
31329455-2	2019	In the present study, we have designed l-tyrosine-tagged hydrophobically (C-10) tailored naphthalene diimide derivative (NDI-i), which formed FONPs in tetrahydrofuran (THF)-water binary solvent mixture.	Water	173-178	homeobox C10	Homo sapiens	74-78
31474993-6	2019	IL-1beta inhibited aquaporins expression and led to water re-absorption disorder.	Water	52-57	interleukin 1 beta	Homo sapiens	0-8
31360962-0	2019	Molecular recognition of organophosphorus compounds in water and inhibition of their toxicity to acetylcholinesterase.	Water	55-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-117
31404098-11	2019	CONCLUSIONS: Inflammatory cytokine IL-1beta via up-regulation of AQPs caused the abnormal metabolism of water transport and loss of the cartilage matrix in the chondrocytes, and ultimately exacerbated the pathogenesis of early osteoarthritis.	Water	104-109	interleukin 1 alpha	Rattus norvegicus	35-43
31382467-7	2019	The results of this study suggest that skin AQP3 expression decreases in diabetes, which may limit water transport from the vessel side to the corneum side, causing dry skin.	Water	99-104	aquaporin 3	Mus musculus	44-48
31447686-1	2019	Arginine vasopressin (AVP) mediates water reabsorption in the kidney collecting ducts through regulation of aquaporin-2 (AQP2).	Water	36-41	arginine vasopressin	Rattus norvegicus	9-20
31382467-2	2019	In this study, we investigated the mechanism underlying the onset of diabetic xeroderma, focusing on aquaporin-3 (AQP3), which plays an important role in water transport in the skin.	Water	154-159	aquaporin 3	Mus musculus	101-112
31399090-0	2019	Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat.	Water	0-5	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	108-114
31440136-6	2019	The effect of LPS on intestinal barrier function was investigated in vitro using intestinal epithelial (IEC-6) cells, and in vivo via administration of LPS in drinking water to Thy1-alphaSyn mice.	Water	168-173	Thy-1 cell surface antigen	Rattus norvegicus	177-181
31390846-7	2019	Experimental results proved that elevated NOM (6.14 mg L-1 as Total Organic Carbon, TOC) in raw water was the root cause for the failure of the plant while the low temperature played a minor but significant role.	Water	96-101	immunoglobulin kappa variable 1-16	Homo sapiens	55-58
31059677-2	2019	GGT transfers the gamma-glutamyl moiety from glutathione (GSH) and other gamma-glutamyl compounds to amino acids, peptides, or water.	Water	127-132	gamma-glutamyltransferase 1	Mus musculus	0-3
31355400-0	2019	Water-soluble polysaccharides from Grifola Frondosa fruiting bodies protect against immunosuppression in cyclophosphamide-induced mice via JAK2/STAT3/SOCS signal transduction pathways.	Water	0-5	signal transducer and activator of transcription 3	Mus musculus	144-149
31141415-6	2019	We previously reported that nesfatin-1 inhibited angiotensin II-induced water drinking in male rats but found no effect of nesfatin-1 in females in diestrus.	Water	72-77	angiotensinogen	Rattus norvegicus	49-63
31026756-7	2019	Meanwhile, the oxygen permeability and water permeability for SPI + CIN + ZnO film are 66.1% and 54.8% of that in regular SPI film, respectively.	Water	39-44	chromogranin A	Homo sapiens	62-65
29464995-3	2019	Magnetic solid-phase adsorption (MSPA) was employed to explore the adsorption behavior of DEA-Calix-MNPs towards Pb(II) from water samples prior to its flame atomic absorption spectrometric analysis.	Water	125-130	submaxillary gland androgen regulated protein 3B	Homo sapiens	113-119
30790544-0	2019	BFSP1 C-terminal domains released by post-translational processing events can alter significantly the calcium regulation of AQP0 water permeability.	Water	129-134	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	124-128
30790544-2	2019	It binds AQP0 in vitro and its C-terminal sequences have been suggested to regulate the water channel activity of AQP0.	Water	88-93	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	9-13
30790544-2	2019	It binds AQP0 in vitro and its C-terminal sequences have been suggested to regulate the water channel activity of AQP0.	Water	88-93	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	114-118
31141395-1	2019	Arginine-vasopressin (AVP)-mediated translocation of aquaporin-2 (AQP2) protein-forming water channels from storage vesicles to the membrane of renal collecting ducts is critical for the renal conservation of water.	Water	88-93	vasopressin	Sus scrofa	9-20
31141395-1	2019	Arginine-vasopressin (AVP)-mediated translocation of aquaporin-2 (AQP2) protein-forming water channels from storage vesicles to the membrane of renal collecting ducts is critical for the renal conservation of water.	Water	209-214	vasopressin	Sus scrofa	9-20
31218788-6	2019	Water LR% positively correlated with that from diets and with Brix values of Lys dissociated in water.	Water	0-5	biogenesis of ribosomes BRX1	Homo sapiens	62-66
31085461-2	2019	The amphiphilic beta-cyclodextrin (beta-CD) self-polymerize in water to form a sphere with a diameter of 40-50 nm.	Water	63-68	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	35-42
31236858-7	2019	The concentration of DBP in water exceeded the China Surface Water Standard.	Water	28-33	D-box binding PAR bZIP transcription factor	Homo sapiens	21-24
31236858-7	2019	The concentration of DBP in water exceeded the China Surface Water Standard.	Water	61-66	D-box binding PAR bZIP transcription factor	Homo sapiens	21-24
31355400-0	2019	Water-soluble polysaccharides from Grifola Frondosa fruiting bodies protect against immunosuppression in cyclophosphamide-induced mice via JAK2/STAT3/SOCS signal transduction pathways.	Water	0-5	cytokine inducible SH2-containing protein	Mus musculus	150-154
31095463-11	2019	The results from this study suggest that DSW could be a potential therapeutic agent for the prevention and treatment of diabetic cardiac hypertrophy.NEW &amp; NOTEWORTHY Deep sea water, containing high levels of minerals, improve cardiac hypertrophy in diabetic rats through attenuating the eccentric signaling pathway, IL-6-MEK5-STAT3, and concentric signaling pathway, IGF2-PKCalpha-CaMKII.	Water	179-184	interleukin 6	Rattus norvegicus	320-324
30826947-6	2019	In addition, both Rock1+/- and Rock2+/- mice showed deficits in long-term potentiation at hippocampal CA1 synapses and were impaired in spatial learning and memory based on the water maze and contextual fear conditioning tests.	Water	177-182	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	31-36
30913760-1	2019	We demonstrate the preparation of water-dispersible polyaniline:polystyrene sulfonate (PANI:PSS), which was doped with camphorsulfonic acid (CSA) and co-doped with poly (4-styrenesulfonic acid) (PSS).	Water	34-39	PSS	Homo sapiens	92-95
30913760-1	2019	We demonstrate the preparation of water-dispersible polyaniline:polystyrene sulfonate (PANI:PSS), which was doped with camphorsulfonic acid (CSA) and co-doped with poly (4-styrenesulfonic acid) (PSS).	Water	34-39	PSS	Homo sapiens	195-198
31374984-3	2019	Molecular docking showed that Rg3 interacted with the aquaporin 1 (AQP1) water channel (binding score -9.4 kJ mol-1).	Water	73-78	aquaporin 1 (Colton blood group)	Homo sapiens	54-65
31374984-3	2019	Molecular docking showed that Rg3 interacted with the aquaporin 1 (AQP1) water channel (binding score -9.4 kJ mol-1).	Water	73-78	aquaporin 1 (Colton blood group)	Homo sapiens	67-71
31374984-6	2019	The results showed that only SRg3 inhibited the AQP1 water flux and inhibited the proliferation of MDA-MB-231 (100 muM), due to cell cycle arrest at G0/G1.	Water	53-58	aquaporin 1 (Colton blood group)	Homo sapiens	48-52
31096067-8	2019	The study hence provides a real-water evidence about the DBP occurrences in a typical distribution system endpoint and the efficiency of a typical POU on mitigating DBP risks.	Water	32-37	D-box binding PAR bZIP transcription factor	Homo sapiens	57-60
30967187-0	2019	Sensitive and anti-interference stripping voltammetry analysis of Pb(II) in water using flower-like MoS2/rGO composite with ultra-thin nanosheets.	Water	76-81	submaxillary gland androgen regulated protein 3B	Homo sapiens	66-72
31311871-6	2019	Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcohols can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD"s lipid substrate, phosphatidylcholine.	Water	134-139	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	166-169
31311871-6	2019	Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcohols can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD"s lipid substrate, phosphatidylcholine.	Water	134-139	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	222-225
31374894-3	2019	Here, we have analyzed topological water networks (TWNs) in the binding pocket of ATX.	Water	35-40	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	82-85
31082641-4	2019	In surface water, the attack of BP3 by hydroxyl radicals (HO ) or carbonate radicals (CO3 -) in UV/H2O2 can generate BP8, which was responsible for the relatively high degradation rate of BP3.	Water	11-16	BP3	Homo sapiens	32-35
31082641-4	2019	In surface water, the attack of BP3 by hydroxyl radicals (HO ) or carbonate radicals (CO3 -) in UV/H2O2 can generate BP8, which was responsible for the relatively high degradation rate of BP3.	Water	11-16	BP3	Homo sapiens	188-191
31177950-0	2019	Bioinspired triangular patterns for water collection from fog.	Water	36-41	zinc finger protein, FOG family member 1	Homo sapiens	58-61
31177950-4	2019	A bioinspired surface, composed of a hydrophilic triangular pattern surrounded by a rim of superhydrophobic region, was used to transport water collected from the fog on the hydrophilic pattern.	Water	138-143	zinc finger protein, FOG family member 1	Homo sapiens	163-166
31177953-1	2019	Cacti use the Laplace pressure gradient due to conical geometry as a mechanism for collecting water from fog.	Water	94-99	zinc finger protein, FOG family member 1	Homo sapiens	105-108
31177953-2	2019	Bioinspired surfaces using conical geometry can be developed for water collection from fog for human consumption.	Water	65-70	zinc finger protein, FOG family member 1	Homo sapiens	87-90
31177963-0	2019	Bioinspired conical design for efficient water collection from fog.	Water	41-46	zinc finger protein, FOG family member 1	Homo sapiens	63-66
31177963-1	2019	Nature is known for using conical shapes to transport the collected water from fog for consumption or storage.	Water	68-73	zinc finger protein, FOG family member 1	Homo sapiens	79-82
31701714-0	2019	[The antioxidant system mediated by Nrf2 in C2C12 cells responding to H2O2 stimulus under different oxygen concentration].	Water	70-74	nuclear factor, erythroid derived 2, like 2	Mus musculus	36-40
31264419-1	2019	In the present work we illustrate the results of classical molecular dynamics simulations of model systems composed of six insulin molecules in water in the presence and in the absence of either epigallocatechin-3-gallate or melatonin molecules.	Water	144-149	insulin	Homo sapiens	123-130
31701714-1	2019	OBJECTIVE: To apply hypoxia of different oxygen concentration on C2C12 cells to study the changes of Nrf2 antioxidant system under H2O2.	Water	131-135	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-105
31338677-4	2019	In the absence of ATZ and the presence of active catalase (CAT), H2O2 is quickly decomposed into water, and the AuNRs will not be etched.	Water	97-102	catalase	Homo sapiens	49-57
31338677-4	2019	In the absence of ATZ and the presence of active catalase (CAT), H2O2 is quickly decomposed into water, and the AuNRs will not be etched.	Water	97-102	catalase	Homo sapiens	59-62
30977957-2	2019	Simple Ni(NO3 )2  6 H2 O as a catalyst precursor formed active nanoparticles, which were effective for the semihydrogenation of several alkynes with high selectivity for the Z-alkene (Z/E&gt;99:1).	Water	20-24	NBL1, DAN family BMP antagonist	Homo sapiens	10-13
31185163-5	2019	Moreover, maximum concentrations that leached from enameled glass fragments according to a standard test that simulates water and other liquids percolating through a landfill were about 1200 and 3200 mug L-1 for Pb and Cd, respectively, with several fragments exceeding the U.S. Model Toxins in Packaging Legislation and, therefore, defined as "hazardous".	Water	120-125	immunoglobulin kappa variable 1-16	Homo sapiens	204-207
31320731-3	2019	We found that the global median Ca concentration was 4.0 mg L-1 with 20.7% of the water samples showing Ca concentrations &lt;= 1.5 mg L-1, a threshold considered critical for the survival of many Ca-demanding organisms.	Water	82-87	immunoglobulin kappa variable 1-16	Homo sapiens	60-63
31030130-8	2019	Compared with CK, TEP and NEP reduced annual surface water flow by 29-43% and 11-16%, and reduced annual soil erosion by 38-54% and 20-33% throughout the study period, respectively.	Water	53-58	membrane metalloendopeptidase	Homo sapiens	26-29
31030130-9	2019	TEP and NEP had significantly lower annual mean concentrations of N and P in surface water.	Water	85-90	membrane metalloendopeptidase	Homo sapiens	8-11
30417658-10	2019	Using the wild-type or Apo E-/- mice exposed to chronic hypoxia as a model, we demonstrated that supplementing drinking water with nitrite suppressed active caspase-6 in the cortex of the brain, concomitant with the prevention of hypoxia-induced anxiety in the animals.	Water	120-125	apolipoprotein E	Mus musculus	23-28
30880180-0	2019	A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway.	Water	16-21	Eph receptor B1	Rattus norvegicus	125-128
30880180-0	2019	A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway.	Water	16-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	129-133
31039529-4	2019	The Ca-HCO3-type drinking water was identified as having high contents of As, pH and HCO3-, a medium-high content EC, and low concentrations of NO3-, SO42-, K+, and Cl-.	Water	26-31	NBL1, DAN family BMP antagonist	Homo sapiens	144-147
31004890-7	2019	Moreover, NO3- (18.577-220.062 mg g-1) was the dominant water-soluble ion and the Ca2+ (2.429-17.209 mg g-1) and Na+ (1.966-20.798 mg g-1) contents in PM2.5 were high.	Water	56-61	NBL1, DAN family BMP antagonist	Homo sapiens	10-13
31315278-4	2019	Oral administration of corn silk water extract (CS) (2 or 4 g/kg/day) for 19 weeks decreased epidermal thickness, wrinkle formation, and positive staining for PCNA, Ki67, and 8-OHdG, and increased collagen staining in UVB-irradiated SKH-1 hairless mice compared with controls.	Water	33-38	proliferating cell nuclear antigen	Zea mays	159-163
31054393-3	2019	Greenhouse gas production has the potential to trade excess NO3- in surface water with excess greenhouses gases in the atmosphere.	Water	76-81	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
31379469-1	2019	High population density and economic development attributing to the changes in water quality in Pa Sak River, Lopburi River, and Mekong River have attracted great attention.	Water	79-84	polo like kinase 4	Homo sapiens	99-102
31246023-0	2019	QM/MM Calculations for the Cl- + CH3Cl SN2 Reaction in Water Using CM5 Charges and Density Functional Theory.	Water	55-60	solute carrier family 38 member 5	Homo sapiens	39-42
31246023-1	2019	The prototypical SN2 reaction of chloride ion with methyl chloride has been reinvestigated in aqueous solution using QM/MM methodology featuring MO6-2X/6-31+G(d) calculations with the TIP4P water model, and partial charges were computed with the CM5 method.	Water	190-195	solute carrier family 38 member 5	Homo sapiens	17-20
30417658-10	2019	Using the wild-type or Apo E-/- mice exposed to chronic hypoxia as a model, we demonstrated that supplementing drinking water with nitrite suppressed active caspase-6 in the cortex of the brain, concomitant with the prevention of hypoxia-induced anxiety in the animals.	Water	120-125	caspase 6	Mus musculus	157-166
31295848-0	2019	Molecular Docking Guided Grid-Independent Descriptor Analysis to Probe the Impact of Water Molecules on Conformational Changes of hERG Inhibitors in Drug Trapping Phenomenon.	Water	85-90	ETS transcription factor ERG	Homo sapiens	130-134
31460306-2	2019	Under physiological conditions, the binding of biocompatible water soluble 1 to human serum albumin (HSA) was studied by spectroscopy techniques, which revealed that 1 could inherent the fluorescent light of HSA in a static quencher course and change the HSA second-level structure.	Water	61-66	albumin	Homo sapiens	86-99
31295848-5	2019	The drug-binding pocket in hERG channels, which lies below the selectivity filter, normally contains K+ ions and water molecules.	Water	113-118	ETS transcription factor ERG	Homo sapiens	27-31
31295848-6	2019	In this study, we test the hypothesis that these water molecules impact drug binding to hERG.	Water	49-54	ETS transcription factor ERG	Homo sapiens	88-92
31295848-7	2019	We developed 3D QSAR models based on alignment independent descriptors (GRIND) using docked ligands in open and closed conformations of hERG in the presence (solvated) and absence (non-solvated) of water molecules.	Water	198-203	ETS transcription factor ERG	Homo sapiens	136-140
31295848-11	2019	The model that exhibits the best statistical values was attained with a cryo_EM structure of the hERG channel in open state without water.	Water	132-137	ETS transcription factor ERG	Homo sapiens	97-101
31272172-1	2019	We use extended depolarized light scattering spectroscopy to study the dynamics of water in a lysozyme-trehalose aqueous solution over a broad time scale, from hundreds to fractions of picoseconds.	Water	83-88	lysozyme	Homo sapiens	94-102
31173012-8	2019	The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE.	Water	54-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-119
31173012-8	2019	The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE.	Water	54-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	258-262
31272172-3	2019	By comparing aqueous solutions of lysozyme with and without trehalose, we show that the combined action of sugar and protein produces an exceptional dynamic slowdown of a fraction of water molecules around the protein, which become more than twice slower than in the absence of trehalose.	Water	183-188	lysozyme	Homo sapiens	34-42
31272172-6	2019	On the basis of these findings, we believe such ultraslow water close to the lysozyme is likely to be involved in the mechanism of bioprotection.	Water	58-63	lysozyme	Homo sapiens	77-85
31284689-6	2019	Absence of the anti-diuretic hormone, arginine vasopressin (AVP), facilitates copious free water urinary excretion (polyuria) in equal volumes to polydipsia to maintain plasma tonicity within normal physiological limits.	Water	91-96	arginine vasopressin	Homo sapiens	47-58
31280283-8	2019	The mechanism of HSVP in regulating intestinal water metabolism in constipated rats may occur through the VIP-cAMP-PKA-AQP3 signaling pathway, and be closely related to changes in intestinal bacteria.	Water	47-52	vasoactive intestinal peptide	Rattus norvegicus	106-109
31333616-5	2019	Vasopressin plays a key role in water homeostasis in the human body and helps to constrict blood vessels.	Water	32-37	arginine vasopressin	Homo sapiens	0-11
31009907-7	2019	Furthermore, K-HBPE@APP was highly water-resistant and has good compatibility with PP matrix.	Water	35-40	amyloid beta precursor protein	Homo sapiens	13-23
30905828-7	2019	Importantly, in vivo transepidermal water loss and permeability studies with murine lipid model membranes revealed that the lipid composition of the APOE-/- skin resulted in a reduced skin barrier function.	Water	36-41	apolipoprotein E	Mus musculus	149-153
31460253-11	2019	VEGF release was governed by diffusion through the water-filled polymer matrix, depending on PEG molecular weight and PEG content of the polymers.	Water	51-56	vascular endothelial growth factor A	Homo sapiens	0-4
31281976-2	2019	Foliar water uptake (FWU) of fog may be fast or slow depending on the species.	Water	7-12	zinc finger protein, FOG family member 1	Homo sapiens	29-32
31004513-9	2019	In contrast, for the difficult differentiation between central diabetes insipidus and primary polydipsia, a stimulated copeptin level of 4.9 pmol/L upon hypertonic saline infusion differentiates these two entities with a high diagnostic accuracy and is clearly superior to the classical water deprivation test.	Water	287-292	arginine vasopressin	Homo sapiens	119-127
31226314-2	2019	It was proposed earlier, that CAH3 could facilitate the H+ removal from the active center of the PSII water-oxidizing complex (WOC) under the light, thereby increasing its activity.	Water	102-107	uncharacterized protein	Chlamydomonas reinhardtii	30-34
31226314-7	2019	Measurements of the photoinduced electron transfer rate in PSII from water or from an artificial electron donor indicate, that CAH3 has a direct influence on the WOC function.	Water	69-74	uncharacterized protein	Chlamydomonas reinhardtii	127-131
31115486-1	2019	Lysophosphatidic acid (LPA), a simple water-soluble glycerophospholipid with growth factor-like activity, regulates certain behaviors of multiple cancer types by binding to its receptor, LPA receptor 2 (LPA2).	Water	38-43	lysophosphatidic acid receptor 2	Homo sapiens	187-201
29457761-5	2019	HP with 1.4 g TiO2 L-1 at pH 7 under sunlight, produced 85% TOC removal in deionized water and 39% in WWTP effluent also after 3 h treatment.	Water	85-90	L1 cell adhesion molecule	Homo sapiens	19-22
30958695-9	2019	Furthermore, metabolomic analysis of murine fecal water detected significant differences in microbe-associated amino acids and short-chain fatty acids between APOE genotypes.	Water	50-55	apolipoprotein E	Mus musculus	159-163
30964709-3	2019	Chow-fed 17-wk-old female Apoe-/- mice treated with 4-PBA-supplemented drinking water for 5 wk exhibited smaller lesions as well as increased plasma levels of heat shock protein (HSP) 25, the mouse homolog of human HSP27, compared with controls.	Water	80-85	apolipoprotein E	Mus musculus	26-30
30964709-6	2019	In summary, drinking water containing 4-PBA attenuated early lesion growth in Apoe-/- mice fed a chow diet and increased expression of HSP25 and HSP27 in macrophages and HSP25 in the circulation of Apoe-/- mice.	Water	21-26	apolipoprotein E	Mus musculus	78-82
30964709-6	2019	In summary, drinking water containing 4-PBA attenuated early lesion growth in Apoe-/- mice fed a chow diet and increased expression of HSP25 and HSP27 in macrophages and HSP25 in the circulation of Apoe-/- mice.	Water	21-26	apolipoprotein E	Mus musculus	198-202
31026699-7	2019	Among the water-soluble ions identified, NO3- had the highest concentration, with further analysis demonstrating the haze evolution was mainly driven by the reactions involving NO3- formation.	Water	10-15	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
31026699-7	2019	Among the water-soluble ions identified, NO3- had the highest concentration, with further analysis demonstrating the haze evolution was mainly driven by the reactions involving NO3- formation.	Water	10-15	NBL1, DAN family BMP antagonist	Homo sapiens	177-180
31247845-0	2019	Exploring Inner-Sphere Water Interactions of Fe(II) and Co(II) Complexes of 12-Membered Macrocycles To Develop CEST MRI Probes.	Water	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
31247845-1	2019	Several paramagnetic Co(II) and Fe(II) macrocyclic complexes were prepared with the goal of introducing a bound water ligand to produce paramagnetically shifted water 1H resonances and for paramagnetic chemical exchange saturation transfer (paraCEST) applications.	Water	112-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
31247845-1	2019	Several paramagnetic Co(II) and Fe(II) macrocyclic complexes were prepared with the goal of introducing a bound water ligand to produce paramagnetically shifted water 1H resonances and for paramagnetic chemical exchange saturation transfer (paraCEST) applications.	Water	161-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
31247845-8	2019	Variable-temperature 17O NMR spectra of Co(II) and Fe(II) NODA complexes were consistent with rapid exchange of the water ligand with bulk water.	Water	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
31247845-8	2019	Variable-temperature 17O NMR spectra of Co(II) and Fe(II) NODA complexes were consistent with rapid exchange of the water ligand with bulk water.	Water	139-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
31247845-9	2019	Notably, the Co(II) and Fe(II) complexes presented here produced substantial paramagnetic shifts of bulk water 1H resonances, independent of having an inner-sphere water.	Water	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
31247845-9	2019	Notably, the Co(II) and Fe(II) complexes presented here produced substantial paramagnetic shifts of bulk water 1H resonances, independent of having an inner-sphere water.	Water	164-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
31115486-1	2019	Lysophosphatidic acid (LPA), a simple water-soluble glycerophospholipid with growth factor-like activity, regulates certain behaviors of multiple cancer types by binding to its receptor, LPA receptor 2 (LPA2).	Water	38-43	lysophosphatidic acid receptor 2	Homo sapiens	203-207
31274842-2	2019	Vasopressin mediates water retention by renal tubular V2 receptor activation as well as vasoconstriction, cardiac hypertrophy, and fibrosis through V1a receptor activation.	Water	21-26	arginine vasopressin	Homo sapiens	0-11
30959301-3	2019	In the north of the study region, an unconfined coarse-grained alluvial aquifer, infiltration of surface irrigation water, sourced from the Oglio River and low in NO3, contributes much to aquifer recharge (up to 88%, as evidenced by a delta2H-Cl/Br mixing model) and has positive effects on groundwater quality by diluting high concentrations of NO3 (decrease by 17% between June and September).	Water	116-121	NBL1, DAN family BMP antagonist	Homo sapiens	163-166
31039249-2	2019	Aquaporin-1 (AQP1) is the water channel directly implicated in CSF production and a potential therapeutic target in the management of CSF circulation disorders.	Water	26-31	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
31039249-2	2019	Aquaporin-1 (AQP1) is the water channel directly implicated in CSF production and a potential therapeutic target in the management of CSF circulation disorders.	Water	26-31	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
30768550-1	2019	INTRODUCTION: Physical exercise or hypoxic exposure influences erythrocyte susceptibility to osmotic stress, and the aquaporin 1 (AQP1) facilitates the transport of water in erythrocytes.	Water	165-170	aquaporin 1 (Colton blood group)	Homo sapiens	117-128
30768550-1	2019	INTRODUCTION: Physical exercise or hypoxic exposure influences erythrocyte susceptibility to osmotic stress, and the aquaporin 1 (AQP1) facilitates the transport of water in erythrocytes.	Water	165-170	aquaporin 1 (Colton blood group)	Homo sapiens	130-134
30565838-3	2019	With the favorable interface effect and hollow structure, the electrodes assembled with MoS2 /NiS hybrid microspheres present remarkably enhanced electrochemical performance for both overall water splitting and asymmetric supercapacitors.	Water	191-196	solute carrier family 5 member 5	Homo sapiens	94-97
30835273-2	2019	However, it is possible that GLP-1 promotes natriuresis under conditions with addition of salt and water to the extracellular fluid.	Water	99-104	glucagon	Homo sapiens	29-34
31100704-7	2019	In hydroponically grown tomato seedlings, AtJUB1 overexpression results in higher prolines levels and improves the maintenance of water content in the plant under salinity stress.	Water	130-135	NAC domain containing protein 42	Arabidopsis thaliana	42-48
30959301-3	2019	In the north of the study region, an unconfined coarse-grained alluvial aquifer, infiltration of surface irrigation water, sourced from the Oglio River and low in NO3, contributes much to aquifer recharge (up to 88%, as evidenced by a delta2H-Cl/Br mixing model) and has positive effects on groundwater quality by diluting high concentrations of NO3 (decrease by 17% between June and September).	Water	116-121	NBL1, DAN family BMP antagonist	Homo sapiens	346-349
30959301-5	2019	Any increase in water-use efficiency in irrigation will reduce this recharge, imperil the spring environments, and lessen the dilution of NO3 leading to increasing NO3 concentrations in groundwater.	Water	16-21	NBL1, DAN family BMP antagonist	Homo sapiens	138-141
30959301-5	2019	Any increase in water-use efficiency in irrigation will reduce this recharge, imperil the spring environments, and lessen the dilution of NO3 leading to increasing NO3 concentrations in groundwater.	Water	16-21	NBL1, DAN family BMP antagonist	Homo sapiens	164-167
31293550-7	2019	And the A. flavus infection and AFs contamination in groundnut, maize, rice and soybean of high water activity were completely inhibited by volatiles from N1-4 in storage.	Water	96-101	leghemoglobin A	Glycine max	155-159
31078963-7	2019	In addition, one of the lead compounds, PP1, has improved water solubility and is significantly more stable when exposed to human blood in comparison to fenofibrate.	Water	58-63	neuropeptide Y receptor Y4	Homo sapiens	40-43
30926555-9	2019	The bone flap was put back over the craniotomy site after soaking in distilled water.	Water	79-84	arachidonate 5-lipoxygenase activating protein	Homo sapiens	9-13
31261789-7	2019	Stimulation with TNF-alpha resulted in a significant increase in HA fibroblast-like synoviocyte proliferation quantified by the water-soluble tetrazolium (WST)-1 assay, while it had no relevant effect on osteoarthritis fibroblast-like synoviocytes.	Water	128-133	tumor necrosis factor	Homo sapiens	17-26
31189221-2	2019	Water reabsorption in the CD depends on the action of arginine vasopressin (AVP) and a transepithelial osmotic gradient between the luminal fluid and surrounding interstitium.	Water	0-5	arginine vasopressin	Homo sapiens	76-79
31189221-3	2019	AVP induces transcellular water reabsorption across CD principal cells through associated signaling pathways after binding to arginine vasopressin receptor 2 (AVPR2).	Water	26-31	arginine vasopressin	Homo sapiens	0-3
31189221-3	2019	AVP induces transcellular water reabsorption across CD principal cells through associated signaling pathways after binding to arginine vasopressin receptor 2 (AVPR2).	Water	26-31	arginine vasopressin receptor 2	Homo sapiens	126-157
31189221-3	2019	AVP induces transcellular water reabsorption across CD principal cells through associated signaling pathways after binding to arginine vasopressin receptor 2 (AVPR2).	Water	26-31	arginine vasopressin receptor 2	Homo sapiens	159-164
31189221-6	2019	Specifically, AVP stimulates the intracellular translocation of AQP2-containing vesicles to the apical plasma membrane, increasing the osmotic water permeability of CD cells.	Water	143-148	arginine vasopressin	Homo sapiens	14-17
31255064-1	2019	In this work, we compare the performance of two structural indicators based on the degree of translational order up to the second coordination shell in three water models: SPC/E, TIP4P/2005, and TIP5P.	Water	158-163	proline rich protein gene cluster	Homo sapiens	172-175
31282895-3	2019	In particular, in the presence of the water extract of Ruta graveolens (RGWE), endothelial cells are no longer able to form a cell-cell network and that the RGWE effects on human umbilical vein endothelial cell (HUVEC) tube formation is abolished by the constitutive activation of MEK.	Water	38-43	mitogen-activated protein kinase kinase 7	Homo sapiens	281-284
30979338-0	2019	APH-1A Component of gamma-Secretase Forms an Internal Water and Ion-Containing Cavity.	Water	54-59	aph-1 homolog A, gamma-secretase subunit	Homo sapiens	0-6
31316725-4	2019	After the AptEpA/EpCAM complex had equilibrated with the water environment through a molecular dynamics simulation at 300 K for 10 ns, stable hydrogen bonds formed between the bases of AptEpA and EpCAM residues of the secondary structures, which included the alpha helix and beta sheet becoming less stable in the water environment.	Water	57-62	epithelial cell adhesion molecule	Homo sapiens	17-22
31316725-4	2019	After the AptEpA/EpCAM complex had equilibrated with the water environment through a molecular dynamics simulation at 300 K for 10 ns, stable hydrogen bonds formed between the bases of AptEpA and EpCAM residues of the secondary structures, which included the alpha helix and beta sheet becoming less stable in the water environment.	Water	57-62	epithelial cell adhesion molecule	Homo sapiens	196-201
31316725-4	2019	After the AptEpA/EpCAM complex had equilibrated with the water environment through a molecular dynamics simulation at 300 K for 10 ns, stable hydrogen bonds formed between the bases of AptEpA and EpCAM residues of the secondary structures, which included the alpha helix and beta sheet becoming less stable in the water environment.	Water	314-319	epithelial cell adhesion molecule	Homo sapiens	17-22
31316725-4	2019	After the AptEpA/EpCAM complex had equilibrated with the water environment through a molecular dynamics simulation at 300 K for 10 ns, stable hydrogen bonds formed between the bases of AptEpA and EpCAM residues of the secondary structures, which included the alpha helix and beta sheet becoming less stable in the water environment.	Water	314-319	epithelial cell adhesion molecule	Homo sapiens	196-201
31316725-5	2019	Those hydrogen bonds formed between the bases of AptEpA and EpCAM loop fragment residues remained stable in the water environment.	Water	112-117	epithelial cell adhesion molecule	Homo sapiens	60-65
30979338-2	2019	Cryo-electron microscopy structures of the enzyme complex revealed a central cavity in its APH-1A component, similar to water-containing cavities in G-protein coupled receptors (GPCRs).	Water	120-125	aph-1 homolog A, gamma-secretase subunit	Homo sapiens	91-97
30979338-4	2019	Our results suggest that APH-1A is able to store water molecules in its inner cavity and transport some of them between cell spaces.	Water	49-54	aph-1 homolog A, gamma-secretase subunit	Homo sapiens	25-31
31258517-4	2019	After host cell invasion, mycobacteria induces the expression of NADPH oxidase 2 (NOX2) to generate superoxide radicals (  O 2 -   ), which are then converted to more toxic hydrogen peroxide (H2O2) by superoxide dismutase (SOD) and subsequently reduced to water by catalase.	Water	256-261	superoxide dismutase 1	Homo sapiens	201-221
30878937-3	2019	Lung cells silenced for Nrf2 (shNrf2) demonstrated diverse susceptibility to various PM extracts; water extracts containing high levels of dissolved metals exhibited higher capacity to generate mitochondrial reactive oxygen species (ROS) and hence increased oxidative stress levels.	Water	98-103	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
31258517-4	2019	After host cell invasion, mycobacteria induces the expression of NADPH oxidase 2 (NOX2) to generate superoxide radicals (  O 2 -   ), which are then converted to more toxic hydrogen peroxide (H2O2) by superoxide dismutase (SOD) and subsequently reduced to water by catalase.	Water	256-261	superoxide dismutase 1	Homo sapiens	223-226
31084025-8	2019	in order to find the lowest enthalpy water-ice crystalline structures in the pressure region 0-8000 bar, in unit cells holding in the range of 1-16 molecules, and a database of the 10 lowest enthalpy structures found at pressures 0, 4000, and 8000 bar is presented.	Water	37-42	carboxylesterase 2	Homo sapiens	43-46
31084004-4	2019	Phospholipase A2 (PLA2), a principal bactericide in human and animal tear secretion, was chosen to drive the in situ lipid giant folds disassembly on water and supported substrate surfaces, respectively.	Water	150-155	phospholipase A2 group IB	Homo sapiens	0-16
31084004-4	2019	Phospholipase A2 (PLA2), a principal bactericide in human and animal tear secretion, was chosen to drive the in situ lipid giant folds disassembly on water and supported substrate surfaces, respectively.	Water	150-155	phospholipase A2 group IB	Homo sapiens	18-22
31112175-8	2019	Chloride abstraction of 5 with TlPF6 in tetrahydrofuran (thf) afforded [Ir(tpp)(PPh3)(thf)](PF6) (6) that reacted with CsOH H2O and Li2S to give the hydroxo [Ir(tpp)(OH)(PPh3)] (7) and hydrosulfido [Ir(tpp)(PPh3)(SH)] (8) complexes, respectively.	Water	124-127	caveolin 1	Homo sapiens	80-84
31112175-8	2019	Chloride abstraction of 5 with TlPF6 in tetrahydrofuran (thf) afforded [Ir(tpp)(PPh3)(thf)](PF6) (6) that reacted with CsOH H2O and Li2S to give the hydroxo [Ir(tpp)(OH)(PPh3)] (7) and hydrosulfido [Ir(tpp)(PPh3)(SH)] (8) complexes, respectively.	Water	124-127	caveolin 1	Homo sapiens	170-174
31112175-8	2019	Chloride abstraction of 5 with TlPF6 in tetrahydrofuran (thf) afforded [Ir(tpp)(PPh3)(thf)](PF6) (6) that reacted with CsOH H2O and Li2S to give the hydroxo [Ir(tpp)(OH)(PPh3)] (7) and hydrosulfido [Ir(tpp)(PPh3)(SH)] (8) complexes, respectively.	Water	124-127	caveolin 1	Homo sapiens	170-174
31112175-12	2019	Oxidation of 8 and 9 with [(4-BrC6H4)3N](SbCl6) led to isolation of 5 and [Ir(tpp)(PPh3)(H2O)]+, respectively.	Water	89-92	caveolin 1	Homo sapiens	83-87
31465019-0	2019	Correction to "Nitrogen-Doped Nanoporous Carbon Nanospheroids for Selective Dye Adsorption and Pb(II) Ion Removal from Waste Water".	Water	125-130	submaxillary gland androgen regulated protein 3B	Homo sapiens	95-101
31185935-2	2019	Aquaporin (AQP) 1 and AQP2, important proteins for renal water reabsorption, have been identified in urinary extracellular vesicles (uEV-AQP1 and -AQP2), and experimental studies have shown that the presence of uEV-AQP1 and -AQP2 may be an indicator of their levels of expression in the kidney.	Water	57-62	aquaporin 1 (Colton blood group)	Homo sapiens	0-17
31185935-2	2019	Aquaporin (AQP) 1 and AQP2, important proteins for renal water reabsorption, have been identified in urinary extracellular vesicles (uEV-AQP1 and -AQP2), and experimental studies have shown that the presence of uEV-AQP1 and -AQP2 may be an indicator of their levels of expression in the kidney.	Water	57-62	aquaporin 1 (Colton blood group)	Homo sapiens	137-141
30826705-9	2019	The ammonolysis was thus demonstrated to be a detoxification process for both individual HAAs and DBP mixture in chlorinated tap water.	Water	129-134	D-box binding PAR bZIP transcription factor	Homo sapiens	98-101
30950157-1	2019	In this study, we report a remarkably active CeVO4 nanozyme that functionally mimics cytochrome c oxidase (CcO), the terminal enzyme in the respiratory electron transport chain, by catalyzing a four-electron reduction of dioxygen to water.	Water	233-238	cytochrome c, somatic	Homo sapiens	85-97
31281400-19	2019	The protective effect of special electromagnetic field treated water and far infrared rays on endotoxin-induced acute respiratory distress syndrome may result from their role in reducing the levels of IL-1beta and IL-6 in serum and the expression level of p65 protein in lung tissue, in addition to reliving inflammatory response, lung coefficient, and lungs edema.	Water	63-68	interleukin 1 beta	Rattus norvegicus	201-209
31281400-19	2019	The protective effect of special electromagnetic field treated water and far infrared rays on endotoxin-induced acute respiratory distress syndrome may result from their role in reducing the levels of IL-1beta and IL-6 in serum and the expression level of p65 protein in lung tissue, in addition to reliving inflammatory response, lung coefficient, and lungs edema.	Water	63-68	interleukin 6	Rattus norvegicus	214-218
31176327-9	2019	This suggests that one must look elsewhere, possibly at water-induced surface rearrangements or some other "defect" structure, for an explanation of ice nucleation by K-feldspar.	Water	56-61	carboxylesterase 2	Homo sapiens	149-152
31281363-2	2019	Inside the biofilm is the nutrient-rich microenvironment promoted by the accumulation of the nutrient ions such as NH4 + and NO3 - from surrounding water.	Water	148-153	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
30926436-1	2019	An immunologically active polysaccharide named as UPP-2 (1035.52 kDa) was isolated from Undaria pinnatifida using traditional water extraction followed by DEAE Sepharose fast flow chromatography.	Water	126-131	uridine phosphorylase 2	Mus musculus	50-55
31077042-1	2019	In this study, the sepiolite-iron oxide-manganese dioxide (Sep-Fe3O4-MnO2) nanocomposite was synthesized and applied as a magnetically separable adsorbent for removal of Pb(II) ions from water in a batch system.	Water	187-192	submaxillary gland androgen regulated protein 3B	Homo sapiens	170-176
31028757-6	2019	We discovered that mice lacking PACAP compared to their wild-type controls exhibited more preference for nicotine over water in the TBC paradigm, particularly at the two higher concentrations of nicotine.	Water	119-124	adenylate cyclase activating polypeptide 1	Mus musculus	32-37
30585644-9	2019	The greatest TGF-beta release was observed after HEDP treatment as compared with EDTA and DW but there was no significant difference between the groups.	Water	90-92	transforming growth factor beta 1	Homo sapiens	13-21
30566641-0	2019	Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H2O Metabolism Pilot Study.	Water	0-5	arginine vasopressin	Homo sapiens	30-38
30566641-0	2019	Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H2O Metabolism Pilot Study.	Water	0-5	arginine vasopressin	Homo sapiens	78-86
30566641-1	2019	OBJECTIVE: Because elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose.	Water	80-85	arginine vasopressin	Homo sapiens	28-36
30566641-1	2019	OBJECTIVE: Because elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose.	Water	141-146	arginine vasopressin	Homo sapiens	166-174
30566641-8	2019	The water-associated reduction of both fasting copeptin and glucose concentration in plasma was most pronounced in participants in the top tertile of baseline copeptin.	Water	4-9	arginine vasopressin	Homo sapiens	47-55
30566641-8	2019	The water-associated reduction of both fasting copeptin and glucose concentration in plasma was most pronounced in participants in the top tertile of baseline copeptin.	Water	4-9	arginine vasopressin	Homo sapiens	159-167
30566641-9	2019	CONCLUSIONS: Water supplementation in persons with habitually low water consumption and high copeptin levels is effective in lowering copeptin.	Water	13-18	arginine vasopressin	Homo sapiens	93-101
30566641-9	2019	CONCLUSIONS: Water supplementation in persons with habitually low water consumption and high copeptin levels is effective in lowering copeptin.	Water	13-18	arginine vasopressin	Homo sapiens	134-142
31116885-1	2019	The objective of this study was to evaluate the effects of a hot-water extract of defatted Camellia oleifera seeds (CSE) in carbon tetrachloride (CCl4 )-induced liver damage in rats.	Water	65-70	C-C motif chemokine ligand 4	Rattus norvegicus	146-150
30790328-13	2019	The water extract derived from heat-killed cells with angiotensin-converting enzyme inhibitory activity, which is known as suppression of inflammation of skin, could protect normal human epidermal keratinocytes (NHEKs) from damage caused by UVB.	Water	4-9	angiotensin I converting enzyme	Homo sapiens	54-83
30853312-7	2019	Retina-specific T cells polarized in vitro towards Th1 or Th17 in the presence of AS101 had impaired ability to induce EAU in naive recipients.	Water	119-122	negative elongation factor complex member C/D, Th1l	Mus musculus	51-54
31140721-3	2019	Micelles containing the negatively charged peptide amphiphile C10 -(Asp)5 are conjugated (a) via a water-soluble, penta-Lys mediator or (b) to micelles containing the C10 -(Lys)5 peptide amphiphile.	Water	99-104	homeobox C10	Homo sapiens	62-73
31140721-3	2019	Micelles containing the negatively charged peptide amphiphile C10 -(Asp)5 are conjugated (a) via a water-soluble, penta-Lys mediator or (b) to micelles containing the C10 -(Lys)5 peptide amphiphile.	Water	99-104	homeobox C10	Homo sapiens	62-65
30945068-12	2019	Sphingolipid metabolism, the Hedgehog signalling pathway and vasopressin-regulated water reabsorption play important roles in nerve damage.	Water	83-88	arginine vasopressin	Homo sapiens	61-72
30417250-4	2019	The gene slc41a1 is ubiquitously expressed in zebrafish tissues and is regulated by water and dietary Mg2+ availability.	Water	84-89	solute carrier family 41 member 1	Danio rerio	9-16
31150435-0	2019	Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of alpha7 nicotinic acetylcholine receptors.	Water	0-5	Ly6/neurotoxin 1	Homo sapiens	31-36
31161726-0	2019	Low pre-exercise muscle glycogen availability offsets the effect of post-exercise cold water immersion in augmenting PGC-1alpha gene expression.	Water	87-92	PPARG coactivator 1 alpha	Homo sapiens	117-127
31161726-1	2019	We assessed the effects of post-exercise cold-water immersion (CWI) in modulating PGC-1alpha mRNA expression in response to exercise commenced with low muscle glycogen availability.	Water	46-51	PPARG coactivator 1 alpha	Homo sapiens	82-92
33597401-2	2019	The causative agent, the blood fluke Schistosoma japonicum, uses an amphibious snail Oncomelania hupensis quadrasi which can harbor larval stages that multiply asexually, eventually producing the infective cercariae which are shed into the water.	Water	240-245	snail family transcriptional repressor 1	Homo sapiens	79-84
33597401-13	2019	Snail infection rates were found to vary considerably across snail sites, which could be due to the degree of fecal contamination of the snail sites and their connectivity to water that can serve as contamination source.	Water	175-180	snail family transcriptional repressor 1	Homo sapiens	0-5
33597401-13	2019	Snail infection rates were found to vary considerably across snail sites, which could be due to the degree of fecal contamination of the snail sites and their connectivity to water that can serve as contamination source.	Water	175-180	snail family transcriptional repressor 1	Homo sapiens	61-66
31411589-11	2019	This catalyst shows good reusability for p-NP degradation and is very easy to recover from the treated water.	Water	103-108	purine nucleoside phosphorylase	Homo sapiens	41-45
31315738-1	2019	OBJECTIVE: To explore the protective effect of hydrogen-rich water on the oxidative stress injury of astrocytes in mice and its effect on phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) signal pathway.	Water	61-66	thymoma viral proto-oncogene 1	Mus musculus	191-194
31315738-15	2019	CONCLUSIONS: Hydrogen-rich water activates the PI3K/Akt pathway, thereby mediates mice astrocytes to exert the biological function of antioxidant.	Water	27-32	thymoma viral proto-oncogene 1	Mus musculus	52-55
31150435-8	2019	The recombinant water-soluble variant of Lynx1 without a GPI-anchor (ws-Lynx1) inhibited the growth of A549 cells causing cell cycle arrest via modulation of alpha7-nAChRs and activation of different intracellular signaling cascades, including PKC/IP3, MAP/ERK, p38, and JNK pathways.	Water	16-21	Ly6/neurotoxin 1	Homo sapiens	41-46
31150435-8	2019	The recombinant water-soluble variant of Lynx1 without a GPI-anchor (ws-Lynx1) inhibited the growth of A549 cells causing cell cycle arrest via modulation of alpha7-nAChRs and activation of different intracellular signaling cascades, including PKC/IP3, MAP/ERK, p38, and JNK pathways.	Water	16-21	Ly6/neurotoxin 1	Homo sapiens	72-77
31150435-8	2019	The recombinant water-soluble variant of Lynx1 without a GPI-anchor (ws-Lynx1) inhibited the growth of A549 cells causing cell cycle arrest via modulation of alpha7-nAChRs and activation of different intracellular signaling cascades, including PKC/IP3, MAP/ERK, p38, and JNK pathways.	Water	16-21	proline rich transmembrane protein 2	Homo sapiens	244-251
31150435-8	2019	The recombinant water-soluble variant of Lynx1 without a GPI-anchor (ws-Lynx1) inhibited the growth of A549 cells causing cell cycle arrest via modulation of alpha7-nAChRs and activation of different intracellular signaling cascades, including PKC/IP3, MAP/ERK, p38, and JNK pathways.	Water	16-21	mitogen-activated protein kinase 1	Homo sapiens	257-260
31150435-8	2019	The recombinant water-soluble variant of Lynx1 without a GPI-anchor (ws-Lynx1) inhibited the growth of A549 cells causing cell cycle arrest via modulation of alpha7-nAChRs and activation of different intracellular signaling cascades, including PKC/IP3, MAP/ERK, p38, and JNK pathways.	Water	16-21	mitogen-activated protein kinase 14	Homo sapiens	262-265
31150435-8	2019	The recombinant water-soluble variant of Lynx1 without a GPI-anchor (ws-Lynx1) inhibited the growth of A549 cells causing cell cycle arrest via modulation of alpha7-nAChRs and activation of different intracellular signaling cascades, including PKC/IP3, MAP/ERK, p38, and JNK pathways.	Water	16-21	mitogen-activated protein kinase 8	Homo sapiens	271-274
30916368-2	2019	In a solution of water and acetonitrile, LED irradiation at lambdamax =285 nm leads to full conversion of 2,5-diphenyltetrazoles with N-ethylmaleimide to the pyrazoline ligation products.	Water	17-22	small integral membrane protein 10 like 2A	Homo sapiens	41-44
31063354-1	2019	A metal-organic gel (metallogel) based on the new tetracarboxyl ligand N1, N4-(diterephthalic acid)terephthalamide in combination with chromium(III) has been converted into its xero- and aerogel and demonstrated to have excellent specific sorption properties for dyes in its metallogel state, where fuchsine is adsorbed faster than the two other dyes, calcein and disulfine blue, and for water, sulfur dioxide and carbon dioxide in its xero- and aerogel state.	Water	388-393	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	144-147
31100904-5	2019	In this study we tested the ability of a water extract from grapevine leaves (VVWE) to inhibit inflammatory conditions in human keratinocytes (HaCaT cells), challenged with proinflammatory (tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS)) or prooxidant (ultraviolet B radiation (UVB) or H2O2) mediators.	Water	41-46	tumor necrosis factor	Homo sapiens	190-217
31111133-1	2019	The new concept of modifying and tailoring the properties of existing two-dimensional (2D) nanomaterials by invoking the assembly of supramolecular networks upon association with a adenine-functionalized macromer (A-PPG) has significant potential to facilitate the development of highly water-dispersible few-layered 2D nanosheets.	Water	287-292	serglycin	Homo sapiens	216-219
31111133-2	2019	In this study, we propose that water-soluble A-PPG directly self-assembles into a long-period stacking-ordered lamellar structure over the surface of hexagonal boron nitride (BN) in aqueous solution, due to the efficient non-covalent interactions between A-PPG and BN nanosheets.	Water	31-36	serglycin	Homo sapiens	47-50
31111133-2	2019	In this study, we propose that water-soluble A-PPG directly self-assembles into a long-period stacking-ordered lamellar structure over the surface of hexagonal boron nitride (BN) in aqueous solution, due to the efficient non-covalent interactions between A-PPG and BN nanosheets.	Water	31-36	serglycin	Homo sapiens	257-260
31041973-1	2019	A coordination compound with the composition [CoLCl2] H2O (L = bis-condensation product of diacetyl and 2-hydrazinyl-4,6-dimethylpyrimidine) was synthesized, in which the Co(ii) ion was hexacoordinated.	Water	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
31117244-6	2019	The naked eye detection limit was 10 mug L-1 where the World Health Organization (WHO) have regulated the maximum level of cyanide in drinking water as 70 mug L-1.	Water	143-148	immunoglobulin kappa variable 1-16	Homo sapiens	41-44
31117244-6	2019	The naked eye detection limit was 10 mug L-1 where the World Health Organization (WHO) have regulated the maximum level of cyanide in drinking water as 70 mug L-1.	Water	143-148	immunoglobulin kappa variable 1-16	Homo sapiens	159-162
31100904-5	2019	In this study we tested the ability of a water extract from grapevine leaves (VVWE) to inhibit inflammatory conditions in human keratinocytes (HaCaT cells), challenged with proinflammatory (tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS)) or prooxidant (ultraviolet B radiation (UVB) or H2O2) mediators.	Water	41-46	tumor necrosis factor	Homo sapiens	219-228
31156579-8	2019	Extended spectrum beta lactamase (ESBL) containing E. coli with the bla ctx-M was found in three water and nine fecal isolates while bla cmy-2 in 19 water and 16 fecal isolates.	Water	97-102	EsbL	Escherichia coli	0-32
31100914-4	2019	Here we applied proteomics and bioinformatics approaches to identify corn silk bioactive peptides (CSBps) that target ACE from the boiling water extract of corn silk (CSE).	Water	139-144	angiotensin I converting enzyme	Rattus norvegicus	118-121
30677743-7	2019	Our findings suggest that chronic fluoride exposure from drinking water is associated with alterations of serum SHBG and ABP concentrations in local male farmers and that the effect of fluoride exposure on ABP levels vary depending on ESRalpha gene polymorphisms.	Water	66-71	sex hormone binding globulin	Homo sapiens	112-116
30677743-7	2019	Our findings suggest that chronic fluoride exposure from drinking water is associated with alterations of serum SHBG and ABP concentrations in local male farmers and that the effect of fluoride exposure on ABP levels vary depending on ESRalpha gene polymorphisms.	Water	66-71	sex hormone binding globulin	Homo sapiens	121-124
30682635-0	2019	Ca2+ protect zebrafish embryos from water acidification.	Water	36-41	carbonic anhydrase II	Danio rerio	0-3
30682635-6	2019	Interestingly, we found that Ca2+ in the embryo medium could increase the tolerance of embryos to acidified water.	Water	108-113	carbonic anhydrase II	Danio rerio	29-32
31156579-8	2019	Extended spectrum beta lactamase (ESBL) containing E. coli with the bla ctx-M was found in three water and nine fecal isolates while bla cmy-2 in 19 water and 16 fecal isolates.	Water	97-102	EsbL	Escherichia coli	34-38
31156579-8	2019	Extended spectrum beta lactamase (ESBL) containing E. coli with the bla ctx-M was found in three water and nine fecal isolates while bla cmy-2 in 19 water and 16 fecal isolates.	Water	149-154	EsbL	Escherichia coli	0-32
31156579-8	2019	Extended spectrum beta lactamase (ESBL) containing E. coli with the bla ctx-M was found in three water and nine fecal isolates while bla cmy-2 in 19 water and 16 fecal isolates.	Water	149-154	EsbL	Escherichia coli	34-38
31156579-10	2019	MLST identified ESBL E. coli belonging to the clinically relevant ST131 clone in six fecal and one water isolate.	Water	99-104	EsbL	Escherichia coli	16-20
30849732-6	2019	High-dose chlorination (10 mg Cl2 L-1) of raw water caused a drastic induction of Nrf2 activity, which was decreased by 70% in water chlorinated after suspended ion exchange.	Water	46-51	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
31096655-4	2019	Expression of myo-inositol 1-phosphate synthase (INPS), the gene responsible for the conversion of glucose-6-phosphate to myo-inositol-1-phosphate, was significantly up regulated in response to a water deficit for the first two sampling weeks.	Water	196-201	myo-inositol-3-phosphate synthase	Glycine max	14-47
31096655-4	2019	Expression of myo-inositol 1-phosphate synthase (INPS), the gene responsible for the conversion of glucose-6-phosphate to myo-inositol-1-phosphate, was significantly up regulated in response to a water deficit for the first two sampling weeks.	Water	196-201	myo-inositol-3-phosphate synthase	Glycine max	49-53
30975917-1	2019	Apical polarity of cystic fibrosis transmembrane conductance regulator (CFTR) is essential for solute and water transport in secretory epithelia and can be impaired in human diseases.	Water	106-111	CF transmembrane conductance regulator	Homo sapiens	19-70
30975917-1	2019	Apical polarity of cystic fibrosis transmembrane conductance regulator (CFTR) is essential for solute and water transport in secretory epithelia and can be impaired in human diseases.	Water	106-111	CF transmembrane conductance regulator	Homo sapiens	72-76
30771925-7	2019	In linear range of 0-2.0 muM, the probe showed good recoveries (from 95% to 108%) for thiophenol detection in natural water samples.	Water	118-123	latexin	Homo sapiens	25-28
30849732-5	2019	Suspended ion exchange had a high capacity to remove dissolved organic carbon (DOC) and to decrease UV absorbance and Nrf2 activity in non-chlorinated water.	Water	151-156	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
30849732-6	2019	High-dose chlorination (10 mg Cl2 L-1) of raw water caused a drastic induction of Nrf2 activity, which was decreased by 70% in water chlorinated after suspended ion exchange.	Water	127-132	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
31002222-0	2019	Coupling a Low Loading of IrP2, PtP2, or Pd3P with Heteroatom-Doped Nanocarbon for Overall Water-Splitting Cells and Zinc-Air Batteries.	Water	91-96	iron responsive element binding protein 2	Homo sapiens	26-30
30763860-8	2019	The chemically pre-treated fresh water (FW) matrix negatively affected the reaction rate when compared with the synthetic water (SW), under the best operational conditions (SSS: pH = 5.5, 287 mg of TiO2, 25  C, SA absence, [DO] = 232-263 muM).	Water	33-38	latexin	Homo sapiens	238-241
31072010-3	2019	AQP3 mRNA was inversely regulated in response to salinity with high levels in ion-poor water (IPW), intermediate levels in freshwater (FW), and low levels in seawater (SW).	Water	87-92	aquaporin-3	Oryzias latipes	0-4
30862673-2	2019	Aquaporin-3 (AQP3) has an important physiological function in renal water reabsorption, and AQP3-mediated hydrogen peroxide (H2O2) permeability can enhance cytokine signaling in several cell types.	Water	68-73	aquaporin 3	Mus musculus	0-11
31077750-6	2020	The TTR-TRbeta CALUX predicted 9/9 compounds and demonstrated competitive activities when analyzing waste water samples.	Water	106-111	T cell receptor beta locus	Homo sapiens	8-14
30997998-9	2019	The rate of PCB emissions from paint colorants is a function of the surface/air equilibrium coefficient, and the presence of water accelerates the emissions.	Water	125-130	pyruvate carboxylase	Homo sapiens	12-15
31002222-5	2019	Notably, the IrP2/NPC-, Pd3P/NPC-, and PtP2/NPC-based water-splitting cells required only 1.62, 1.65, and 1.68 V, respectively, to deliver the current density of 10 mA cm-2.	Water	54-59	iron responsive element binding protein 2	Homo sapiens	13-17
31026155-0	2019	Experimental and Simulation Studies of Aquaporin 0 Water Permeability and Regulation.	Water	51-56	major intrinsic protein of lens fiber	Homo sapiens	39-50
31026155-4	2019	We also review experimental and theoretical progress toward understanding why mammalian AQP0 has a lower water permeability than other aquaporins and the evolution of our present understanding of how its water permeability is regulated by pH and calcium.	Water	105-110	major intrinsic protein of lens fiber	Homo sapiens	88-92
31026155-4	2019	We also review experimental and theoretical progress toward understanding why mammalian AQP0 has a lower water permeability than other aquaporins and the evolution of our present understanding of how its water permeability is regulated by pH and calcium.	Water	204-209	major intrinsic protein of lens fiber	Homo sapiens	88-92
30862673-2	2019	Aquaporin-3 (AQP3) has an important physiological function in renal water reabsorption, and AQP3-mediated hydrogen peroxide (H2O2) permeability can enhance cytokine signaling in several cell types.	Water	68-73	aquaporin 3	Mus musculus	13-17
30862673-5	2019	Here, using a calcein fluorescence quenching assay, we screened a library of 7360 drug-like small molecules for inhibition of mouse AQP3 water permeability.	Water	137-142	aquaporin 3	Mus musculus	132-136
30862673-7	2019	Surprisingly, inhibitor specificity testing revealed that the methylurea-linked compound Z433927330, a partial AQP3 inhibitor (IC50, ~0.7-0.9 mum), is a potent and efficacious inhibitor of mouse AQP7 water permeability (IC50, ~0.2 mum).	Water	200-205	aquaporin 3	Mus musculus	111-115
30856427-0	2019	Oxygen-reducing microbial cathodes monitoring toxic shocks in tap water.	Water	66-71	USO1 vesicle transport factor	Homo sapiens	62-65
31048563-4	2019	The water-soluble dimethylaminomicheliolide (DMAMCL), can inhibit NF-kappaB activity and is currently undergoing clinical trials.	Water	4-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
30828757-9	2019	The present method was successfully applied for the detection of Cu2+ and ALP in real water samples and in human serum samples, respectively.	Water	86-91	alkaline phosphatase, placental	Homo sapiens	74-77
30802427-1	2019	Aquaporin 0 (AQP0) is essential for eye lens homeostasis as is regulation of its water permeability by Ca2+, which occurs through interactions with calmodulin (CaM), but the underlying molecular mechanisms are not well understood.	Water	81-86	major intrinsic protein of lens fiber	Homo sapiens	0-11
30802427-1	2019	Aquaporin 0 (AQP0) is essential for eye lens homeostasis as is regulation of its water permeability by Ca2+, which occurs through interactions with calmodulin (CaM), but the underlying molecular mechanisms are not well understood.	Water	81-86	major intrinsic protein of lens fiber	Homo sapiens	13-17
30802427-2	2019	Here, we use molecular dynamics (MD) simulations on the microsecond timescale under an osmotic gradient to explicitly model water permeation through the AQP0 channel.	Water	124-129	major intrinsic protein of lens fiber	Homo sapiens	153-157
30802427-3	2019	To identify any structural features that are specific to water permeation through AQP0, we also performed simulations of aquaporin 1 (AQP1) and a pure mixed lipid bilayer under the same conditions.	Water	57-62	major intrinsic protein of lens fiber	Homo sapiens	82-86
30802427-5	2019	Our simulations allowed us to characterize the dynamics of the key structural elements that modulate the diffusion of water single-files through the AQP0 and AQP1 pores.	Water	118-123	major intrinsic protein of lens fiber	Homo sapiens	149-153
30802427-5	2019	Our simulations allowed us to characterize the dynamics of the key structural elements that modulate the diffusion of water single-files through the AQP0 and AQP1 pores.	Water	118-123	aquaporin 1 (Colton blood group)	Homo sapiens	158-162
30856427-6	2019	Here we show that O2-reducing EABs can grow in unamended tap water on carbon electrodes at + 0.2 V vs. Ag/AgCl.	Water	61-66	USO1 vesicle transport factor	Homo sapiens	57-60
30637977-5	2019	Additionally, one water molecule located between the B-C loop and the I helix mediated different hydrogen-bonding networks between CYP3A4/3A5 and SE.	Water	18-23	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-137
30961359-6	2019	Moreover, when we induced upregulation of NIX, autophagy was increased, while neuronal apoptosis and brain water content decreased along with neurological deficits.	Water	107-112	BCL2 interacting protein 3 like	Rattus norvegicus	42-45
30824083-4	2019	The paper sample modified with a wax-treated (CR/CS/MMT/CS)2 multilayer gave a water contact angle of 151.4 .	Water	79-84	chorionic somatomammotropin hormone 2	Homo sapiens	46-60
30698843-5	2019	These results demonstrate the variety of small-molecule disinfection byproduct structures that are capable of binding to the ER, and that their weak binding can still be of importance when overall human exposure to mixtures of disinfection byproducts in disinfected drinking water is considered.	Water	275-280	estrogen receptor 1	Homo sapiens	125-127
31232288-6	2019	It was determined that the mean rate of biodegradation of PHA in the marine environment is 0.04-0.09 mg day-1 cm-2 (p = 0.05) and that, for example, a PHA water bottle could be expected to take between 1.5 and 3.5 years to completely biodegrade.	Water	155-160	lamin B receptor	Homo sapiens	58-61
30460574-1	2019	Arginine vasopressin (AVP), which induces vasoconstriction and conserves solute-free water when released during high plasma osmolality, is secreted through 2 mechanisms: osmoregulation and baroregulation.	Water	85-90	arginine vasopressin	Homo sapiens	9-20
30565859-4	2019	Structural analysis revealed that ISL bound to BRD4 with a novel binding mode and squeezed out one of the six conserved water molecules that form a strong hydrogen bond network.	Water	120-125	bromodomain containing 4	Homo sapiens	47-51
30604903-7	2019	We found that Abeta-positive subjects had increased baseline right uncinate fasciculus free-water fraction (FW), associated with worse baseline Alzheimer"s disease assessment scale scores.	Water	92-97	amyloid beta precursor protein	Homo sapiens	14-19
30265778-2	2019	Water incubation of the PU films (with 9.2-31.1 wt % PEG) caused a surface enrichment of PEG chains where vascular endothelial growth factor (VEGF) was grafted by forming secondary amine linkages between VEGF molecules and the PEG spacer.	Water	0-5	vascular endothelial growth factor A	Homo sapiens	106-140
30265778-2	2019	Water incubation of the PU films (with 9.2-31.1 wt % PEG) caused a surface enrichment of PEG chains where vascular endothelial growth factor (VEGF) was grafted by forming secondary amine linkages between VEGF molecules and the PEG spacer.	Water	0-5	vascular endothelial growth factor A	Homo sapiens	142-146
30265778-2	2019	Water incubation of the PU films (with 9.2-31.1 wt % PEG) caused a surface enrichment of PEG chains where vascular endothelial growth factor (VEGF) was grafted by forming secondary amine linkages between VEGF molecules and the PEG spacer.	Water	0-5	vascular endothelial growth factor A	Homo sapiens	204-208
31232288-6	2019	It was determined that the mean rate of biodegradation of PHA in the marine environment is 0.04-0.09 mg day-1 cm-2 (p = 0.05) and that, for example, a PHA water bottle could be expected to take between 1.5 and 3.5 years to completely biodegrade.	Water	155-160	lamin B receptor	Homo sapiens	151-154
30683391-4	2019	It is shown that in the ABDI mass spectra of a number of compounds (protonated morphine ions in water and RDX adducts with chlorine in acetonitrile), the ratios I2/I1 and I3/I2 linearly depend on the analyte concentration in the solution.	Water	96-101	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	161-176
30858164-3	2019	AQP1 is a dual water and cyclic-nucleotide-gated cation channel located in lamellipodia and is essential for rapid cell migration in a subset of aggressive cancers.	Water	15-20	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
30726978-4	2019	The measured incident energy of the alpha-particles was 3.3 +- 0.5 MeV (LET in water = 120 keV mum-1), with a maximum incident dose rate of 1.28 +- 0.02 Gy min-1, which for a 5 mum cell monolayer corresponds to a mean dose rate of 1.57 +- 0.02 Gy min-1 and a mean LET in water of 154 keV mum-1.	Water	271-276	CD59 molecule (CD59 blood group)	Homo sapiens	156-161
31844611-3	2019	Haem oxygenase-1 (HO-1) is a cytoprotective protein that rescues cells from H2O2 or high glucose-induced apoptosis.	Water	76-80	heme oxygenase 1	Mus musculus	0-16
31006349-2	2019	Treatment of ground water F with epididymal sperm suspension caused complete loss of sperm motility and decrease in the activities of superoxide dismutase (SOD) and catalase (CAT) and increase in the concentration of malondialdehyde (MDA) and abnormality of spermatozoa at 15 and 30 min time intervals.	Water	20-25	superoxide dismutase 1	Homo sapiens	156-159
31006349-2	2019	Treatment of ground water F with epididymal sperm suspension caused complete loss of sperm motility and decrease in the activities of superoxide dismutase (SOD) and catalase (CAT) and increase in the concentration of malondialdehyde (MDA) and abnormality of spermatozoa at 15 and 30 min time intervals.	Water	20-25	catalase	Homo sapiens	165-173
31006349-2	2019	Treatment of ground water F with epididymal sperm suspension caused complete loss of sperm motility and decrease in the activities of superoxide dismutase (SOD) and catalase (CAT) and increase in the concentration of malondialdehyde (MDA) and abnormality of spermatozoa at 15 and 30 min time intervals.	Water	20-25	catalase	Homo sapiens	175-178
31006349-3	2019	Further, incubation of spermatozoa with ground water F for 5, 10, and 15 min time intervals significantly reduced the sperm motility and activities of SOD and CAT and increased the concentration of MDA and abnormality of spermatozoa.	Water	47-52	superoxide dismutase 1	Homo sapiens	151-154
31006349-3	2019	Further, incubation of spermatozoa with ground water F for 5, 10, and 15 min time intervals significantly reduced the sperm motility and activities of SOD and CAT and increased the concentration of MDA and abnormality of spermatozoa.	Water	47-52	catalase	Homo sapiens	159-162
31844611-3	2019	Haem oxygenase-1 (HO-1) is a cytoprotective protein that rescues cells from H2O2 or high glucose-induced apoptosis.	Water	76-80	heme oxygenase 1	Mus musculus	18-22
30583363-0	2019	Characterization of bovine serum albumin hydrolysates prepared by subcritical water processing.	Water	78-83	albumin	Homo sapiens	27-40
30712591-7	2019	The method was optimized and validated for the determination of 29 pesticides in water, showing good linearity in the range between 0.012 and 40.00 mug L-1 with determination coefficients of R2 &gt; 0,9649.	Water	81-86	L1 cell adhesion molecule	Homo sapiens	152-155
30925213-3	2019	In this combined experimental and computational study, we show that imidazolium functionalization of molecular fac-Mn(CO)3 bipyridine complexes results in CO2 reduction at mild electrochemical potentials in the presence of H2O.	Water	223-226	FA complementation group C	Homo sapiens	111-114
31459840-0	2019	High-Throughput Experimental Study of Wurtzite Mn1-x Zn x O Alloys for Water Splitting Applications.	Water	71-76	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	47-50
31459840-10	2019	Overall, this study demonstrates that Mn1-x Zn x O alloys hold promise for photoelectrochemical water splitting, which could be enhanced with further tailoring of their electronic properties.	Water	96-101	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	38-41
30975755-7	2019	We find that the antagonists shift CCR2 into several stable inactive conformations that are distinct from the crystal structure conformation and disrupt a continuous internal water and sodium ion pathway, preventing transitions to an active-like state.	Water	175-180	C-C motif chemokine receptor 2	Homo sapiens	35-39
30572091-10	2019	Following fractionation of the TC plant material, the ethyl acetate fraction had interesting antioxidant activity and the methanol/water (35%) and hexane fractions had good 15-LOX inhibitory activity.	Water	131-136	arachidonate 15-lipoxygenase	Mus musculus	173-179
30989159-7	2019	The results indicate that a single Ce atom and a Ce2 cluster can react with a maximum of four and six water molecules, respectively, while a Ce3 cluster can react with more than six water molecules.	Water	102-107	carboxylesterase 2	Homo sapiens	49-52
30989159-7	2019	The results indicate that a single Ce atom and a Ce2 cluster can react with a maximum of four and six water molecules, respectively, while a Ce3 cluster can react with more than six water molecules.	Water	182-187	carboxylesterase 2	Homo sapiens	49-52
31009998-1	2019	Cystic Fibrosis (CF) is the most common fatal human genetic disease, which is caused by a defect in an anion channel protein (CFTR) that affects ion and water transport across the epithelium.	Water	153-158	CF transmembrane conductance regulator	Homo sapiens	126-130
30925049-5	2019	[Nd(NO3)3(H2O)(dppz-R)] with R = H, NO2-, CN- and their [Nd(NO3)3(H2O)(dpq)] analogue, which was computationally modeled.	Water	10-13	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
30791184-6	2019	2.8 mg L-1 ) under continuous operating mode, data indicates that about 1750 kg water m-2 membrane can be treated while maintaining drinking water quality, and the saturated membranes can be regenerated and reused several times without decrease in performance.	Water	80-85	L1 cell adhesion molecule	Homo sapiens	7-10
30999674-4	2019	Ripened cow"s milk cheese had higher values of WSN/TN (water-soluble nitrogen per total nitrogen content) and TCA-SN/TN (nitrogen soluble in 12% trichloroacetic acid per total nitrogen), but similar PTA-SN/TN (nitrogen soluble in 5% phosphotungstic acid per total nitrogen) values were observed in ripened cheeses.	Water	55-60	Weaning weight-maternal milk	Bos taurus	14-18
30999674-5	2019	The antioxidant potential of a WSF (water-soluble fraction) was higher in goat"s milk cheese, but higher TEAC (total antioxidant capacity) values of WINF (water-insoluble fraction) were observed in matured cow"s milk cheese.	Water	36-41	Weaning weight-maternal milk	Bos taurus	81-85
30919628-6	2019	In response to caspase-3/7, the water-soluble peptide DEVD is cleaved and the remaining Gd(III)-AIEgen (Gad-AIE) conjugate aggregates leading to increased FL-MR signals.	Water	32-37	caspase 3	Homo sapiens	15-26
30925049-5	2019	[Nd(NO3)3(H2O)(dppz-R)] with R = H, NO2-, CN- and their [Nd(NO3)3(H2O)(dpq)] analogue, which was computationally modeled.	Water	66-69	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
30925049-5	2019	[Nd(NO3)3(H2O)(dppz-R)] with R = H, NO2-, CN- and their [Nd(NO3)3(H2O)(dpq)] analogue, which was computationally modeled.	Water	10-13	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
30925049-5	2019	[Nd(NO3)3(H2O)(dppz-R)] with R = H, NO2-, CN- and their [Nd(NO3)3(H2O)(dpq)] analogue, which was computationally modeled.	Water	66-69	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
31013775-1	2019	AqB013 and AqB050 compounds inhibit aquaporin 1 (AQP1), a dual water and ion channel implicated in tumour angiogenesis.	Water	63-68	aquaporin 1 (Colton blood group)	Homo sapiens	36-47
30896927-5	2019	The overall method performance was satisfactory with limits of quantification under 50 ng L-1 for most of analytes in both surface and drinking water.	Water	144-149	immunoglobulin kappa variable 1-16	Homo sapiens	90-93
30833158-3	2019	Simulation of water networks in combination with docking enabled us to identify the key waters and to optimize our primary hit into a low nanomolar JAK2 lead with promising selectivity over JAK1.	Water	14-19	Janus kinase 1	Homo sapiens	190-194
30544095-3	2019	The results of health risk assessment indicated that cancer risk as well as non-cancer risks of THMs in WTPs sourced from five water systems decreased in the order of WS3 &gt; WS5 &gt; WS2 &gt; WS1 &gt; WS4.	Water	127-132	dynactin subunit 6	Homo sapiens	167-170
30544095-5	2019	However, when drinking boiled water, dermal contact is the major risk source for WTPs with raw water from WS1 and WS2, instead of dermal contact, inhalation becomes the major risk source for WTPs with raw water from WS3, WS4, and WS5.	Water	30-35	paired box 3	Homo sapiens	106-109
30544095-5	2019	However, when drinking boiled water, dermal contact is the major risk source for WTPs with raw water from WS1 and WS2, instead of dermal contact, inhalation becomes the major risk source for WTPs with raw water from WS3, WS4, and WS5.	Water	30-35	dynactin subunit 6	Homo sapiens	216-219
30544095-5	2019	However, when drinking boiled water, dermal contact is the major risk source for WTPs with raw water from WS1 and WS2, instead of dermal contact, inhalation becomes the major risk source for WTPs with raw water from WS3, WS4, and WS5.	Water	95-100	paired box 3	Homo sapiens	106-109
30544095-5	2019	However, when drinking boiled water, dermal contact is the major risk source for WTPs with raw water from WS1 and WS2, instead of dermal contact, inhalation becomes the major risk source for WTPs with raw water from WS3, WS4, and WS5.	Water	95-100	paired box 3	Homo sapiens	106-109
30544095-6	2019	In WTPs with raw water from water systems WS1, WS3, WS4, and WS5, dibromochloromethane (DBCM) in THMs has the highest contribution to cancer risk, while chloroform in THMs has the highest contribution to non-cancer risk.	Water	17-22	paired box 3	Homo sapiens	42-45
30731339-5	2019	This paper presents a mixed-methods study of poor households" access to piped water in rural Viet Nam, providing insight into local dynamics of the water/poverty nexus.	Water	78-83	SH3 and cysteine rich domain 3	Homo sapiens	98-101
31013775-1	2019	AqB013 and AqB050 compounds inhibit aquaporin 1 (AQP1), a dual water and ion channel implicated in tumour angiogenesis.	Water	63-68	aquaporin 1 (Colton blood group)	Homo sapiens	49-53
30978967-4	2019	Employing human blood-based in vitro tests, the LPS isolated from complex water bloom revealed the priming of both major blood phagocyte population monocytes and polymorphonuclear leukocytes documented by the increased surface expression of CD11b and CD66b.	Water	74-79	CEA cell adhesion molecule 8	Homo sapiens	251-256
30888790-0	2019	Mixed-Ligand-Architected 2D Co(II)-MOF Expressing a Novel Topology for an Efficient Photoanode for Water Oxidation Using Visible Light.	Water	99-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
31191978-0	2019	Correction: Water intake after dehydration makes muscles more susceptible to cramp but electrolytes reverse that effect.	Water	12-17	cathelicidin antimicrobial peptide	Homo sapiens	77-82
31031620-11	2019	Salvianolic-acid B (SA-B), a water-soluble element of Salvia miltiorrhiza known to have anti-fibrosis effects, attenuated both basal and TGF-beta1-induced increased levels of MEF2A and C mRNA and protein.	Water	29-34	SH3 domain binding protein 5	Homo sapiens	20-24
30826060-0	2019	A predominant form of C-terminally end-cleaved AQP0 functions as an open water channel and an adhesion protein in AQP0DeltaC/DeltaC mouse lens.	Water	73-78	major intrinsic protein of lens fiber	Mus musculus	47-51
30826060-11	2019	Our experiments clearly show that C-terminally end-cleaved AQP0 can function both as a water channel and a CTCA molecule in the lens fiber cell membranes.	Water	87-92	major intrinsic protein of lens fiber	Mus musculus	59-63
30758020-10	2019	As this system contains oil and water, both the organogelator DBS and the hydrogelator HG1 can gel these LLCs, but this clearly does not apply to all organogelators/hydrogelators.	Water	32-37	polycystin 1, transient receptor potential channel interacting pseudogene 1	Homo sapiens	87-90
30826060-1	2019	The purpose of this investigation was to find out whether C-terminally end-cleaved aquaporin 0 (AQP0), that is present predominantly in the lens mature fiber cells of the WT, functions as a water channel and a cell-to-cell adhesion (CTCA) protein in a knockin (KI) mouse model (AQP0DeltaC/DeltaC) that does not express intact AQP0.	Water	190-195	major intrinsic protein of lens fiber	Mus musculus	83-94
30826060-1	2019	The purpose of this investigation was to find out whether C-terminally end-cleaved aquaporin 0 (AQP0), that is present predominantly in the lens mature fiber cells of the WT, functions as a water channel and a cell-to-cell adhesion (CTCA) protein in a knockin (KI) mouse model (AQP0DeltaC/DeltaC) that does not express intact AQP0.	Water	190-195	major intrinsic protein of lens fiber	Mus musculus	96-100
30685680-9	2019	It was noted that BP-1 and its chlorinated products were found in swimming pool water samples.	Water	80-85	BP1	Homo sapiens	18-22
30970608-1	2019	The water channel Aquaporin 1 (AQP1) plays a fundamental role in water ultrafiltration during peritoneal dialysis (PD) and its reduced expression or function may be responsible for ultrafiltration failure (UFF).	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	31-35
30970608-1	2019	The water channel Aquaporin 1 (AQP1) plays a fundamental role in water ultrafiltration during peritoneal dialysis (PD) and its reduced expression or function may be responsible for ultrafiltration failure (UFF).	Water	65-70	aquaporin 1 (Colton blood group)	Homo sapiens	31-35
30597373-0	2019	Recyclable polyvinyl alcohol sponge containing flower-like layered double hydroxide microspheres for efficient removal of As(V) anions and anionic dyes from water.	Water	157-162	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	122-127
30637965-0	2019	Atomic Layer Deposition of NiOOH/Ni(OH)2 on PIM-1-Based N-Doped Carbon Nanofibers for Electrochemical Water Splitting in Alkaline Medium.	Water	102-107	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	44-49
31087940-6	2019	The annual dynamics of the dissolved N2O concentration were primarily governed by the concentration of NO3--N in the stream water, with denitrification being the main process producing N2O.	Water	124-129	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
31087940-8	2019	The temporal variations in the saturation levels of the dissolved N2O were mainly controlled by the water temperature and the NO3--N concentration of the stream water.	Water	161-166	NBL1, DAN family BMP antagonist	Homo sapiens	126-129
31087940-9	2019	During April-October, the concentration of dissolved N2O in the stream fluctuated obviously as a result of heavy rainfall, which resulted in an increase of the concentration of NO3-N in the stream water in the short term after the rain, which promoted denitrification and then increased the dissolved N2O level correspondingly.	Water	197-202	NBL1, DAN family BMP antagonist	Homo sapiens	177-180
30431652-5	2019	Excitingly, the 2D vdW MoTe2 /CrS2 heterojunction is demonstrated, for the first time, to be 2D near-infrared-light driven photocatalyst for direct Z-scheme water splitting.	Water	157-162	msh homeobox 2	Homo sapiens	30-34
30637965-8	2019	This study provides insight into the design of 1D-aligned N-doped PIM-1 electrospun carbon nanofibers as a flexible and free-standing NiOOH/Ni(OH)2 decorated electrode as a highly stable nanocatalyst for water splitting in an alkaline medium.	Water	204-209	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	66-71
30659792-6	2019	Using these computed values along with the data from the latest literature on AQP1 and on erythrocyte proteomics, we estimated the water and glycerol transport rates across the membrane of an entire erythrocyte.	Water	131-136	aquaporin 1 (Colton blood group)	Homo sapiens	78-82
30827094-5	2019	An aptamer that can bind the glycoprotein alkaline phosphatase (ALP) with relative weak affinity and specificity was used as a ligand, and controllable oriented surface imprinting was carried out with an in-water self-polymerization system of dopamine.	Water	207-212	alkaline phosphatase, placental	Homo sapiens	64-67
30811182-7	2019	Comparing the total toxicity-weighted DBP concentration between reuse and drinking waters provides drinking water as a rational benchmark for water quality comparison, explicitly recognizes that contaminants occur as mixtures, provides utilities flexibility in selecting the most efficient treatment trains to reduce estimated toxicity, and can be expanded to encompass new contaminants as toxic potency data become available.	Water	83-88	D-box binding PAR bZIP transcription factor	Homo sapiens	38-41
30811182-7	2019	Comparing the total toxicity-weighted DBP concentration between reuse and drinking waters provides drinking water as a rational benchmark for water quality comparison, explicitly recognizes that contaminants occur as mixtures, provides utilities flexibility in selecting the most efficient treatment trains to reduce estimated toxicity, and can be expanded to encompass new contaminants as toxic potency data become available.	Water	108-113	D-box binding PAR bZIP transcription factor	Homo sapiens	38-41
30659788-9	2019	Water extracts from flax fabric diminished the proliferation of monocytoid cells, decreased oxidative burst in activated THP1 cells and accelerated the velocity of dermal microvascular cell migration.	Water	0-5	GLI family zinc finger 2	Homo sapiens	121-125
30940895-5	2019	The mean ideotype yields of 15.0-19.0 t ha-1 were achieved in water-limited conditions in the UK and NZ, whereas 15.6-19.5 t ha-1 under irrigated conditions.	Water	62-67	Rho GTPase activating protein 45	Homo sapiens	40-44
32398909-8	2019	Patients of group A and group B were given Vatari Guggulu and Seetarama Vati respectively with warm water after meal for one month.	Water	100-105	vesicle amine transport 1	Homo sapiens	72-76
30684007-7	2019	We showed that MLC1 and GlialCAM were enriched and assembled into mature complexes in astrocyte perivascular endfeet between postnatal days 10 and 15, after the formation of astrocyte perivascular Aquaporin 4 water channels.	Water	209-214	modulator of VRAC current 1	Homo sapiens	15-19
30815830-8	2019	Immersing insulin under water after the vial has been pierced carries a high risk of contamination, leading to loss of potency and likelihood of causing injection abscesses.	Water	24-29	insulin	Homo sapiens	10-17
30805837-3	2019	BTCA-P-Cu-MCP was used for removal and preconcentration of Pb(II) ions from environmental water samples prior to flame atomic absorption spectrometry(FAAS) analysis.	Water	90-95	submaxillary gland androgen regulated protein 3B	Homo sapiens	59-65
30805837-10	2019	The recoveries from 94.75 +- 4 to 100.93 +- 1.9% were obtained for rapid extraction of trace levels of Pb(II) ions in different water samples.	Water	128-133	submaxillary gland androgen regulated protein 3B	Homo sapiens	103-109
30702925-2	2019	Previously, our lab showed in vitro heteromer formation between angiotensin II receptor type 1 subtype a (AT1aR) and secretin receptor (SCTR), which is involved in in vivo control of hyperosmolality-induced water drinking behavior.	Water	207-212	angiotensinogen	Homo sapiens	64-78
30927942-3	2019	PURPOSE: To detect the association of insulin resistance with marrow adiposity in postmenopausal women with newly diagnosed type 2 diabetes (T2D) using chemical shift-encoded water-fat MRI.	Water	175-180	insulin	Homo sapiens	38-45
30702925-5	2019	The results from this study not only are consistent with our hypothesis that SCT and ANGII interact at the receptor level to mediate their water homeostatic activities but also provide evidence for in vivo functions of cross-class GPCR heteromers.-Mak, S. O. K., Zhang, L., Chow, B. K. C. In vivo actions of SCTR/AT1aR heteromer in controlling Vp expression and release via cFos/cAMP/CREB pathway in magnocellular neurons of PVN.	Water	139-144	angiotensinogen	Homo sapiens	85-90
30676864-0	2019	Modulation of cardiac vascular endothelial growth factor and PGC-1alpha with regular postexercise cold-water immersion of rats.	Water	103-108	PPARG coactivator 1 alpha	Rattus norvegicus	61-71
30874698-2	2019	An ionic liquid (IL) was explored in this study as a promising reaction medium for the maltose glycation of soy protein isolate (SPI) to decrease water activity and to shift the reaction equilibrium.	Water	146-151	chromogranin A	Homo sapiens	129-132
30735853-4	2019	RESULTS: The PTSD and TEC groups demonstrated lower gamma-amino butyric acid (GABA)/H2O (p = 0.02) and glutamine (Gln)/H2O (p = 0.02) in the dACC as compared to the NTEC group.	Water	119-122	Acetyl-CoA carboxylase	Drosophila melanogaster	141-145
30735853-6	2019	Further, GABA/H2O in the dACC correlated negatively with sleep symptoms in the PTSD group (p = 0.03) but not in the TEC and NTEC groups.	Water	14-17	Acetyl-CoA carboxylase	Drosophila melanogaster	25-29
30735853-8	2019	CONCLUSIONS: Exposure to trauma in veterans may be associated with lower GABA/H2O and Gln/H2O in the dACC, suggesting disruption in the GABA-Gln-glutamate cycle.	Water	90-93	Acetyl-CoA carboxylase	Drosophila melanogaster	101-105
30735853-10	2019	Further, lower GABA/H2O in the ACC was associated with poor sleep in the PTSD group.	Water	20-23	Acetyl-CoA carboxylase	Drosophila melanogaster	31-34
30900716-6	2019	Compared with green tea, significantly decreased levels of water extract, tea polyphenol and amino acid were found in dark tea, whereas the content of both caffeine and gallocatechin was increased.	Water	59-64	dark	Mus musculus	118-122
30561030-2	2019	Humans are exposed to PCB mixtures via contaminated food or water.	Water	60-65	pyruvate carboxylase	Homo sapiens	22-25
30676864-14	2019	NEW &amp; NOTEWORTHY A regular postexercise cold-water immersion for 10 wk of endurance training augmented the myocardial mitochondrial biogenesis and vascular angiogenesis coactivators peroxisome proliferator-activated receptor gamma coactivator-1alpha and vascular endothelial growth factor, respectively.	Water	49-54	PPARG coactivator 1 alpha	Rattus norvegicus	186-253
30830789-1	2019	Milk is an attractive lipid-based formulation for the delivery of poorly water-soluble drugs to pediatric populations.	Water	73-78	Weaning weight-maternal milk	Bos taurus	0-4
30933433-1	2019	PURPOSE: Proton CT (pCT) has the ability to reduce inherent uncertainties in proton treatment by directly measuring the relative proton stopping power with respect to water, thereby avoiding the uncertain conversion of X-ray CT Hounsfield unit to relative stopping power and the deleterious effect of X- ray CT artifacts.	Water	167-172	calcitonin related polypeptide alpha	Homo sapiens	9-18
30933433-1	2019	PURPOSE: Proton CT (pCT) has the ability to reduce inherent uncertainties in proton treatment by directly measuring the relative proton stopping power with respect to water, thereby avoiding the uncertain conversion of X-ray CT Hounsfield unit to relative stopping power and the deleterious effect of X- ray CT artifacts.	Water	167-172	calcitonin related polypeptide alpha	Homo sapiens	20-23
30887585-4	2019	Thus, the present study aimed to clarify the mechanisms involved in the modulation exerted by oestradiol on AVP secretion, specifically investigating the involvement of ERbeta, ERalpha and TRPV1 receptors in response to water deprivation (WD).	Water	220-225	estrogen receptor 1	Homo sapiens	169-175
30887585-4	2019	Thus, the present study aimed to clarify the mechanisms involved in the modulation exerted by oestradiol on AVP secretion, specifically investigating the involvement of ERbeta, ERalpha and TRPV1 receptors in response to water deprivation (WD).	Water	220-225	estrogen receptor 1	Homo sapiens	177-184
30045671-8	2019	Body weight reduction was most rapid in the group given tap water and decreased with increasing sucrose concentrations.	Water	60-65	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	56-59
30045671-9	2019	A drastic drop in body weight was observed in mice placed in metabolic cages for four consecutive days with access to tap water and food, indicating that time spent in metabolic cages should be kept to a minimum, as prolonged confinement in metabolic cages can be harmful to mice.	Water	122-127	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	118-121
30679042-9	2019	CONCLUSIONS: Filler elements in CAD/CAM composite resins used in this study leached into purified water.	Water	98-103	calmodulin 3	Homo sapiens	36-39
30830789-9	2019	We conclude that although milk could enhance the solubilization of poorly water-soluble OZ439 during in vitro digestion principally due to the formation of fatty acids, the solubilization efficiency was reduced by the presence of FQ by competition for the available fatty acids.	Water	74-79	Weaning weight-maternal milk	Bos taurus	26-30
31033226-9	2019	Yet, water restriction only elevated urinary osmolality by 28% in these mice as opposed to 104% in non-SCD mice despite similar degree increases of protein abundance of AQP2, NKCC2 and AQP2-S256-P. Water-restriction had no significant effect on protein abundance of ENaC or AQP1 in either strain.	Water	5-10	solute carrier family 12, member 1	Mus musculus	175-180
31459741-5	2019	The results showed that water absorption capacities of the modified SAP in salt solutions were improved due to the adsorption and transfer of water molecules by the sulfonic acid groups.	Water	24-29	SH2 domain containing 1A	Homo sapiens	68-71
31459741-5	2019	The results showed that water absorption capacities of the modified SAP in salt solutions were improved due to the adsorption and transfer of water molecules by the sulfonic acid groups.	Water	142-147	SH2 domain containing 1A	Homo sapiens	68-71
32254807-3	2019	The as-prepared PB-MoO3-x nanocomposites (NCs) with a uniform particle size of ~90 nm and high water dispersibility exhibited strong optical absorption in the first biological window, which is induced by plasmon resonance in an oxygen-deficient MoO3-x semiconductor.	Water	95-100	modifier of obesity 3	Mus musculus	19-23
30822766-4	2019	The LOD of cyanide by R in water is 0.6 muM, which is much lower than the permissible limit of cyanide in drinking water according to the WHO.	Water	27-32	latexin	Homo sapiens	40-43
30850533-8	2019	Mechanistically, TLR4-dependent surface expression of P-selectin triggered an unconventional mechanism of complement activation by noncovalent anchoring of C3 activation fragments, including the typical fluid-phase C3(H2O), measured by surface plasmon resonance and flow cytometry.	Water	218-221	selectin, platelet	Mus musculus	54-64
30971910-4	2019	The combination of Abeta and ET1 pathological states leads to an alteration in microvascular anatomy, texture, diameter, density, and protein expression, in addition to disturbed vessel-matrix-connections, inter-compartmental water exchange and basement membrane profile within the lesion epicenter localized in the striatum of Abeta+ET1 brains compared to Abeta and ET1 rats.	Water	226-231	endothelin 1	Rattus norvegicus	29-32
30949471-4	2019	Ni-Zn/SiO2 showed a high catalytic activity when water was used as a solvent, where the reaction was completed within 6 min at room temperature with a specific reaction rate of 4.3 ml min-1 mmol-cat-1 mM-AB-1.	Water	49-54	CD59 molecule (CD59 blood group)	Homo sapiens	184-189
30968014-4	2019	Results indicate that nitrate can be removed from source waters using FCDI to concentrations &lt;1 mg NO3-N L-1 though a lower quality target such as 10 mg L-1 would be more cost-effective, particularly where the influent nitrate concentration is high (50 mg NO3-N L-1).	Water	57-63	immunoglobulin kappa variable 1-16	Homo sapiens	108-111
30850533-8	2019	Mechanistically, TLR4-dependent surface expression of P-selectin triggered an unconventional mechanism of complement activation by noncovalent anchoring of C3 activation fragments, including the typical fluid-phase C3(H2O), measured by surface plasmon resonance and flow cytometry.	Water	218-221	toll-like receptor 4	Mus musculus	17-21
30909375-5	2019	The curved 3D bumpy hybrid surface exhibits an over 16 times higher water collection rate than the flat 2D hybrid surface in the fog stream in parallel to the hybrid surface.	Water	68-73	zinc finger protein, FOG family member 1	Homo sapiens	129-132
30758007-6	2019	The significant negative relationship between the water temperature and delta18O-NO3- values indicated the occurrence of nitrification in the soil throughout the year.	Water	50-55	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
30469069-8	2019	NO3--N was the subset of water chemistry parameters that best explained bacterial community dissimilarities, while "river length" was the subset of geographic distance parameters that best explained bacterial community dissimilarities.	Water	25-30	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
30870430-2	2019	We previously reported that high water intake (HWI) reduced urine osmolality and urinary arginine vasopressin, improved renal function, and reduced the kidney/body weight ratio in PCK rats, an orthologous model of human PKD.	Water	33-38	arginine vasopressin	Rattus norvegicus	98-109
30810308-1	2019	Stoichiometric electron-transfer (ET) oxidation of two diastereomeric mu-peroxo-mu-hydroxo dinuclear Co(III) complexes with tris(2-pyridylmethyl)amine (TPA) was examined to scrutinize the reaction mechanism of O2 evolution from the peroxo complexes, as seen in the final step in water oxidation by a Co(III)-TPA complex.	Water	279-284	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	101-108
30810308-1	2019	Stoichiometric electron-transfer (ET) oxidation of two diastereomeric mu-peroxo-mu-hydroxo dinuclear Co(III) complexes with tris(2-pyridylmethyl)amine (TPA) was examined to scrutinize the reaction mechanism of O2 evolution from the peroxo complexes, as seen in the final step in water oxidation by a Co(III)-TPA complex.	Water	279-284	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	104-107
30580142-4	2019	Capturing cobalt (Co(II)) from filtered river water doped with competing metals (Cu, As, Ag, Cd, Hg, Tl, and Pb) was most effective from pH 5-8 with binding affinity ranged from IDAA &gt; DE4A &gt; ED3A &gt; Ac-Phos &gt; SH on SAMMS.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30753058-7	2019	The organogelation property displayed by the beta3,beta(O)-delta5-Phe dipeptide was further explored to recover the oil spills from the oil-water mixture.	Water	140-145	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	45-65
30577122-6	2019	The median concentrations were &lt;100 ng L-1 and 220 ng g-1 (d.w.) in the water and sediments, respectively.	Water	75-80	L1 cell adhesion molecule	Homo sapiens	42-60
30850706-9	2019	These findings suggest that tap water in high income countries could serve as an important source of community exposure to ESBL and carbapenemase genes, and that these genes may be disseminated by non-Enterobacteriaceae that are not detected as part of standard microbiological water quality testing.	Water	32-37	EsbL	Escherichia coli	123-127
31087971-4	2019	Total OPEs (Sigma7OPEs) ranged from 689.09 to 10623.94 ng L-1, with the mean of 3747.58 ng L-1 in the surface water.	Water	110-115	immunoglobulin kappa variable 1-16	Homo sapiens	91-94
30899546-0	2019	Water intake after dehydration makes muscles more susceptible to cramp but electrolytes reverse that effect.	Water	0-5	cathelicidin antimicrobial peptide	Homo sapiens	65-70
30698594-3	2019	Thus, we prepared telechelic PEO with glucose molecules to form water-soluble lamellar nanostructures by co-assembly with metallacarborane.	Water	64-69	twinkle mtDNA helicase	Homo sapiens	29-32
30793135-4	2019	In our work, we use computer simulations with the TIP4P/Ice water model to investigate such a change of slope.	Water	60-65	carboxylesterase 2	Homo sapiens	56-59
30663118-4	2019	Herein, core-shell nanoparticles based poly(lactic-co-glycolic) acid (PLGA) are fabricate, by encapsulating water-soluble catalase (Cat), an enzyme that can decompose H2 O2 to generate O2 , inside the inner core, and loading hydrophobic imiquimod (R837), a Toll-like-receptor-7 agonist, within the PLGA shell.	Water	108-113	catalase	Mus musculus	122-130
30837513-10	2019	Sand mulching combined with the SAP decreased evaporation in each layer relative to the control, which retained more water and decreased the accumulation of surface salt in the order 1.0% &gt; 0.5% &gt; 0.2% &gt; 0.1% &gt; 0.	Water	117-122	SH2 domain containing 1A	Homo sapiens	32-35
30940993-0	2019	Phenolic Compounds from Water-Ethanol Extracts of Tetrapleura tetraptera Produced in Cameroon, as Potential Protectors against In Vivo CCl4-Induced Liver Injuries.	Water	24-29	C-C motif chemokine ligand 4	Rattus norvegicus	135-139
30504006-9	2019	The strongest effects of ovocystatin were found in the group of AD mice, where ovocystatin was administered in drinking water at a dose of 40 mug/mouse (p &lt; 0.05).	Water	120-125	cystatin C	Gallus gallus	25-36
30504006-9	2019	The strongest effects of ovocystatin were found in the group of AD mice, where ovocystatin was administered in drinking water at a dose of 40 mug/mouse (p &lt; 0.05).	Water	120-125	cystatin C	Gallus gallus	79-90
30663118-4	2019	Herein, core-shell nanoparticles based poly(lactic-co-glycolic) acid (PLGA) are fabricate, by encapsulating water-soluble catalase (Cat), an enzyme that can decompose H2 O2 to generate O2 , inside the inner core, and loading hydrophobic imiquimod (R837), a Toll-like-receptor-7 agonist, within the PLGA shell.	Water	108-113	catalase	Mus musculus	132-135
30841460-10	2019	RESULTS: High expression of MEG3 was identified in rat models of MACAO, the brain tissues of which manifested obvious neurological impairment, increased infarct area, water content, BBB permeability, accelerated neuronal apoptosis and necrosis, increased surviving neurons, upregulated expression of key proteins in Wnt/beta-catenin signaling pathway and elevated levels of BDNF, NGF and bFGF.	Water	167-172	similar to GTL2, imprinted maternally expressed untranslated	Rattus norvegicus	28-32
30379098-0	2019	(Pro)renin receptor contributes to pregnancy-induced sodium-water retention in rats via activation of intrarenal RAAS and alpha-ENaC.	Water	60-65	ATPase H+ transporting accessory protein 2	Rattus norvegicus	5-19
30841450-6	2019	In BV2 microglia cells, ICE markedly inhibited production of nitric oxide and proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 without causing cytotoxicity.	Water	24-27	tumor necrosis factor	Mus musculus	112-139
30665681-2	2019	Known CD4 mimics such as NBD-556 possess significant anti-HIV activity but are less soluble in water, perhaps due to their hydrophobic aromatic ring-containing structures.	Water	95-100	CD4 molecule	Homo sapiens	6-9
30665681-4	2019	Some of these new CD4 mimics, containing a tetramethylpiperidine ring show significantly higher water solubility than NBD-556 and have high anti-HIV activity and synergistic anti-HIV activity with a neutralizing antibody.	Water	96-101	CD4 molecule	Homo sapiens	18-21
30841450-6	2019	In BV2 microglia cells, ICE markedly inhibited production of nitric oxide and proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 without causing cytotoxicity.	Water	24-27	interleukin 1 beta	Mus musculus	141-158
30841460-11	2019	With the treatment of si-MEG3, the MEG3 expression was reduced; whereby, modeled rats showed ameliorated neurological impairment, reduced infarct area, water content, BBB permeability, neuronal apoptosis and necrosis and significantly enhanced neurogenesis.	Water	152-157	similar to GTL2, imprinted maternally expressed untranslated	Rattus norvegicus	25-29
30841450-6	2019	In BV2 microglia cells, ICE markedly inhibited production of nitric oxide and proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 without causing cytotoxicity.	Water	24-27	interleukin 6	Mus musculus	164-177
30609490-5	2019	The mean Sb concentration in the wetlands water is 7.03 mug L-1, which consist of pentavalent, trivalent, organic Sb dissolved in water and a great part that attached to suspend solids (SS).	Water	42-47	immunoglobulin kappa variable 1-16	Homo sapiens	60-63
30543961-5	2019	In both the FO and UF parts of the VRO-LPM process, PSS had a higher water flux than CMC.	Water	69-74	PSS	Homo sapiens	52-55
30508798-9	2019	Without the use of consumable reducing agents (i.e. H2 gas), sonocatalytic reduction could be a potential candidate of remediation method to treat NO3- polluted water with high N2 selectivity and easy magnetic recovery.	Water	161-166	NBL1, DAN family BMP antagonist	Homo sapiens	147-150
30609490-5	2019	The mean Sb concentration in the wetlands water is 7.03 mug L-1, which consist of pentavalent, trivalent, organic Sb dissolved in water and a great part that attached to suspend solids (SS).	Water	130-135	immunoglobulin kappa variable 1-16	Homo sapiens	60-63
30430736-1	2019	One of the most intriguing properties of plasma membrane intrinsic protein (PIP) aquaporins (AQPs) is their ability to modulate water transport by sensing different levels of intracellular pH through the assembly of homo- and heterotetrameric molecular species in the plasma membrane.	Water	128-133	prolactin induced protein	Homo sapiens	41-74
31950754-1	2019	A lead carboxylate-azolate framework, [Pb3 (mu4 -O)(L)2 (H2 O)]   2H2 O (1), has been constructed from the reaction of 2-methyl-4-(1H-tetrazol-5-yl) benzoic acid (H2 L) and Pb(NO3 )2 under solvothermal conditions.	Water	57-61	NBL1, DAN family BMP antagonist	Homo sapiens	173-179
31950754-1	2019	A lead carboxylate-azolate framework, [Pb3 (mu4 -O)(L)2 (H2 O)]   2H2 O (1), has been constructed from the reaction of 2-methyl-4-(1H-tetrazol-5-yl) benzoic acid (H2 L) and Pb(NO3 )2 under solvothermal conditions.	Water	66-71	NBL1, DAN family BMP antagonist	Homo sapiens	173-179
30430736-1	2019	One of the most intriguing properties of plasma membrane intrinsic protein (PIP) aquaporins (AQPs) is their ability to modulate water transport by sensing different levels of intracellular pH through the assembly of homo- and heterotetrameric molecular species in the plasma membrane.	Water	128-133	prolactin induced protein	Homo sapiens	76-79
30270529-5	2019	RESULTS AND CONCLUSIONS: Through their construction, alpha AHA and PHA are able to bind large amounts of water and act as potent antioxidant agents through inhibition of matrix metalloproteinases and strong chelating properties.	Water	105-110	lamin B receptor	Homo sapiens	67-70
31184819-9	2019	CONCLUSIONS: In this study, cTnT level, which is regarded as one of the most specific markers of cardiac injury, was found to be lower in the athletes who underwent cold water immersion.	Water	170-175	troponin T2, cardiac type	Homo sapiens	28-32
30417425-7	2019	In particular, the rate constants corresponding to the repair of 8-OH-G adducts were found to be in the order of 104  M-1 s-1 and are assisted by a water molecule.	Water	148-153	tumor associated calcium signal transducer 2	Homo sapiens	118-125
30264484-7	2019	This work indicates that Tyr 71 stabilizes catalytic water in the aspartyl dyad active site, enabling BACE-1 activity.	Water	53-58	beta-secretase 1	Homo sapiens	102-108
30488437-15	2019	These data increase our understanding of the independent pathways that can phosphorylate different residues in the AQP2 C-terminus, and suggest new strategies to target distinct AQP2 serine residues to induce membrane expression of this water channel when VP signalling is defective.	Water	237-242	vasopressin	Sus scrofa	256-258
30676741-4	2019	X-ray crystallography and molecular docking analysis of PioOH-bound PPARgamma ligand-binding domain revealed an altered hydrogen bonding network, including the formation of water-mediated bonds, which could underlie its altered biochemical phenotype.	Water	173-178	peroxisome proliferator activated receptor gamma	Homo sapiens	68-77
33597429-11	2019	This study highlights O. viverrini infection as a significant endemic disease with potential health problems among the water-based communities along the Nam Kam River.	Water	119-124	SH3 and cysteine rich domain 3	Homo sapiens	153-156
30478450-2	2019	The renin-angiotensin system (RAS) is a major physiological regulatory pathway controlling salt-water equilibrium, intravascular volume and blood pressure.	Water	96-101	renin	Homo sapiens	4-9
30530125-9	2019	Moreover, when tested in tap water, greater than 90% of BrO3- was removed after 60 min reaction in UV/FeTi-0.5 (pH 7.0) LDH systems in the presence of 5% (v/v) methanol.	Water	29-34	SEC14 like lipid binding 2	Homo sapiens	25-28
30808892-7	2019	We propose that the structural diversity of PrP fibrils encompass a multiplicity of packing defects (water-excluded cavities) in their hydrophobic cores, and that the resultant sensitivity to pressure should be considered as a general molecular criterion to accurately define fibril morphotypes.	Water	101-106	prion protein	Homo sapiens	44-47
30818779-2	2019	Here, we aimed to evaluate the effect of a water-based standardized green coffee extract (GCE) on cardiometabolic parameters in ApoE-/- mice and to explore the potential underlying mechanisms.	Water	43-48	apolipoprotein E	Mus musculus	128-132
30813620-1	2019	In cystic fibrosis (CF), mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene disrupt the capacity of the encoded protein to function as a channel to transport chloride ions and water across cell membranes.	Water	206-211	CF transmembrane conductance regulator	Homo sapiens	42-93
30813620-1	2019	In cystic fibrosis (CF), mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene disrupt the capacity of the encoded protein to function as a channel to transport chloride ions and water across cell membranes.	Water	206-211	CF transmembrane conductance regulator	Homo sapiens	95-99
30412882-6	2019	This study points to excess nutrients in HCMC"s water body with concentrations of NH4+ and PO43- averaging to 0.7 +- 0.6 mgN L-1 and 0.07 +- 0.06 mgP L-1, respectively in mean over the monitored period and rising up to 3 mgN L-1 and 0.2 mgP L-1, in extreme conditions.	Water	48-53	L1 cell adhesion molecule	Homo sapiens	125-128
30412882-6	2019	This study points to excess nutrients in HCMC"s water body with concentrations of NH4+ and PO43- averaging to 0.7 +- 0.6 mgN L-1 and 0.07 +- 0.06 mgP L-1, respectively in mean over the monitored period and rising up to 3 mgN L-1 and 0.2 mgP L-1, in extreme conditions.	Water	48-53	L1 cell adhesion molecule	Homo sapiens	150-153
30412882-6	2019	This study points to excess nutrients in HCMC"s water body with concentrations of NH4+ and PO43- averaging to 0.7 +- 0.6 mgN L-1 and 0.07 +- 0.06 mgP L-1, respectively in mean over the monitored period and rising up to 3 mgN L-1 and 0.2 mgP L-1, in extreme conditions.	Water	48-53	L1 cell adhesion molecule	Homo sapiens	225-244
30721060-0	2019	Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.	Water	236-241	non-nucleoside reverse transcriptase inhibitor	None	40-86
30813522-7	2019	Oxygen stable isotope ratios in milk water were relatively lower in winter and transitional seasons and higher in summer, showing the dependence on the main water source.	Water	37-42	Weaning weight-maternal milk	Bos taurus	32-36
30813522-7	2019	Oxygen stable isotope ratios in milk water were relatively lower in winter and transitional seasons and higher in summer, showing the dependence on the main water source.	Water	157-162	Weaning weight-maternal milk	Bos taurus	32-36
30813224-7	2019	In the group exposed to swimming training exercise in cold water, a significantly higher activity of SOD1 (by 13.4%) was found compared to the control group.	Water	59-64	superoxide dismutase 1	Rattus norvegicus	101-105
30863065-3	2019	Results: The bFGF + IBU/PECT hydrogel formed a stable, water-dispersible nanoparticle core shell that was injectable at room temperature, hydrogel in situ at body temperature, and provided sustained release of both hydrophilic and hydrophobic drugs.	Water	55-60	fibroblast growth factor 2	Homo sapiens	13-17
30676756-3	2019	The simulations consistently predict that the most dominant mechanism is the proton-assisted SN2 process, where the protonation of the hydroxyl group by water and the C-O bond breaking and formation occur in a single step.	Water	153-158	solute carrier family 38 member 5	Homo sapiens	93-96
30326455-6	2019	Evidence for biological and hydrological variability of NO3- isotope fractionation means that values measured in aerobic surface water environments are most appropriately evaluated by a range of fractionation values, rather than commonly used single "site specific" epsilondenit values.	Water	129-134	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
30633519-7	2019	CYP450 is a heme enzyme that contains a ferric ion (FeIII) coordinated by a porphyrin ligand, a water molecule, and a cysteinate ligand that is provided by a strategic residue of the encapsulating protein.	Water	96-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-6
30668108-14	2019	Further reflecting the role of the ligand in tuning reactivity, the trimetallic trihydride cluster compounds, [M3(mu-H)3]3+ (M = FeII, CoII, ZnII), demonstrate substrate specificity for CO2 over various other unsaturated molecules and surprising stability toward water.	Water	263-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
30906330-2	2019	This study quantified and described ESBL- and KPC-producing E. coli in Northern Colorado from sewer water, surface water, and influent and effluent wastewater treatment sources.	Water	100-105	EsbL	Escherichia coli	36-40
30906330-6	2019	The total E. coli abundance decreased through the water treatment process as expected, yet the percentages of E. coli harboring ESBL resistance were increased (1.70%) in surface water.	Water	178-183	EsbL	Escherichia coli	128-132
30253359-6	2019	The model results show that pool water characteristics (e.g., total organic content, temperature, conductivity, pH and alkalinity) and management factors (e.g., the number of bathers and sprayers) have direct effects on DBP concentrations.	Water	33-38	D-box binding PAR bZIP transcription factor	Homo sapiens	220-223
30529825-2	2019	The water extracts had the highest antioxidant activity, especially those from roots and flowers, and were further appraised for in vitro inhibition of enzymes implicated on the onset of human ailments, namely acetyl- (AChE) and butyrylcholinesterase (BuChE) for Alzheimer"s disease, alpha-glucosidase and alpha-amylase for diabetes, and tyrosinase for skin hyperpigmentation disorders.	Water	4-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	219-223
30781505-0	2019	Removing Metal Ions from Water with Graphene-Bovine Serum Albumin Hybrid Membrane.	Water	25-30	albumin	Homo sapiens	52-65
30366240-4	2019	From August through October, concentrations of dissolved Zn in overlying water (338 ~ 1023 mug L-1) exceeded the water quality limit for fisheries in China (100 mug L-1).	Water	73-78	immunoglobulin kappa variable 1-16	Homo sapiens	95-98
30384050-10	2019	Besides, in the real river water, the MCs@Mg/Fe-LDHs also exhibited stable adsorption capacity for Pb(II).	Water	27-32	submaxillary gland androgen regulated protein 3B	Homo sapiens	99-105
30266053-5	2019	Unfiltered natural surface water samples were exposed to GO and Ag-GO at a final concentration of 10 to 100 mg L-1 for 48 h. The activity of leucine aminopeptidase was significantly lowered within 1 h of GO and Ag-GO treatments and nitrification rate was significantly lowered.	Water	27-32	carboxypeptidase Q	Homo sapiens	149-163
30714061-5	2019	The predicted reaction pathways show that the single Ce atom and the Ce2 and Ce3 clusters can all easily react with H2O and dissociate the water molecule.	Water	116-119	carboxylesterase 2	Homo sapiens	69-72
30316091-2	2019	This study focuses on the impact of residential water heating on CBP levels in tap water.	Water	48-53	CREB binding protein	Homo sapiens	65-68
30663758-3	2019	300 ns MD simulations of beta-casein in water and in the presence of different SDS concentrations at 300 K were performed.	Water	40-45	casein beta	Bos taurus	25-36
30714061-5	2019	The predicted reaction pathways show that the single Ce atom and the Ce2 and Ce3 clusters can all easily react with H2O and dissociate the water molecule.	Water	139-144	carboxylesterase 2	Homo sapiens	69-72
30714061-7	2019	The reaction of either Ce2 or Ce3 with a single H2O molecule can fully dissociate the H2O into H and O atoms while it is bonded with the Ce cluster.	Water	48-51	carboxylesterase 2	Homo sapiens	23-26
30714061-7	2019	The reaction of either Ce2 or Ce3 with a single H2O molecule can fully dissociate the H2O into H and O atoms while it is bonded with the Ce cluster.	Water	86-89	carboxylesterase 2	Homo sapiens	23-26
30755658-2	2019	Most LHA populations promote food and water consumption but LHA neurotensin (Nts) neurons preferentially induce water intake while suppressing feeding.	Water	112-117	neurotensin	Homo sapiens	64-75
30755658-2	2019	Most LHA populations promote food and water consumption but LHA neurotensin (Nts) neurons preferentially induce water intake while suppressing feeding.	Water	112-117	neurotensin	Homo sapiens	77-80
30967063-0	2019	Designing bioinspired surfaces for water collection from fog.	Water	35-40	zinc finger protein, FOG family member 1	Homo sapiens	57-60
30891134-4	2019	Based on our recently solved CCR2 structure with MK-0812 and molecular dynamics (MD) simulations, we show that the RT for this and structurally related ligands is directly dependent on the shielding of the Tyr120-Glu291 H-bond from the water.	Water	236-241	C-C motif chemokine receptor 2	Homo sapiens	29-33
30292115-5	2019	Both the apparent diffusion flux estimation and the DGT induced flux in sediments (DIFS) simulation indicated that As(V) contamination in surface sediments of mariculture, harbor and petrochemical areas suffered the potential risk of As(V) release into the overlying water from sediments.	Water	267-272	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-120
30169661-5	2019	In this study, we prepared anti-FCN1 monoclonal antibody (mAb) and examined its therapeutic potential in mice treated with Candida albicans water-soluble fraction (CAWS), which induces KD-like vasculitis in the coronary artery.	Water	140-145	ficolin A	Mus musculus	32-36
30732636-9	2019	Concerning water conservancy projects, the main purpose is to control snail migration from snail area to snail-free areas nationwide.	Water	11-16	snail family transcriptional repressor 1	Homo sapiens	70-75
30693356-3	2019	Here, we use molecular dynamics simulations of the SPC/E water model to study the surface tension of water (sigmaw) as a function of temperature down to 198.15 K, and find a minimum point of surface excess entropy per unit area around ~240-250 K. Additional simulations with the TIP4P/2005 water model also show consistent results.	Water	101-106	proline rich protein gene cluster	Homo sapiens	51-54
30732636-9	2019	Concerning water conservancy projects, the main purpose is to control snail migration from snail area to snail-free areas nationwide.	Water	11-16	snail family transcriptional repressor 1	Homo sapiens	91-96
30732636-9	2019	Concerning water conservancy projects, the main purpose is to control snail migration from snail area to snail-free areas nationwide.	Water	11-16	snail family transcriptional repressor 1	Homo sapiens	91-96
30693356-3	2019	Here, we use molecular dynamics simulations of the SPC/E water model to study the surface tension of water (sigmaw) as a function of temperature down to 198.15 K, and find a minimum point of surface excess entropy per unit area around ~240-250 K. Additional simulations with the TIP4P/2005 water model also show consistent results.	Water	101-106	proline rich protein gene cluster	Homo sapiens	51-54
30726233-3	2019	Nanoparticles were used for modification of glassy carbon electrode (GCE) and new sensor was applied for simultaneous determination of Pb(II) and Cd(II) ions in water samples with the linear sweep anodic stripping voltammetry (LSASV).The factors such as pH, deposition potential and deposition time are optimized.	Water	161-166	submaxillary gland androgen regulated protein 3B	Homo sapiens	135-141
30764501-1	2019	In this cross-sectional study, we measured the association between water provision and milk production on intensively managed small-scale grazing dairy herds.	Water	67-72	Weaning weight-maternal milk	Bos taurus	87-91
30605314-2	2019	The 18O/16O of NO3- produced by nitrification is often assumed to reflect the proportional contribution of oxygen atom sources, water, and molecular oxygen, in a 2:1 ratio.	Water	128-133	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
30605314-5	2019	Resulting NO3- 18O/16O ratios showed (1) a disproportionate sensitivity to the 18O/16O ratio of water, mediated by isotopic equilibration between water and NO2-, as well as (2) kinetic isotope discrimination during O atom incorporation from molecular oxygen and water.	Water	96-101	NBL1, DAN family BMP antagonist	Homo sapiens	10-13
30605314-5	2019	Resulting NO3- 18O/16O ratios showed (1) a disproportionate sensitivity to the 18O/16O ratio of water, mediated by isotopic equilibration between water and NO2-, as well as (2) kinetic isotope discrimination during O atom incorporation from molecular oxygen and water.	Water	146-151	NBL1, DAN family BMP antagonist	Homo sapiens	10-13
30605314-5	2019	Resulting NO3- 18O/16O ratios showed (1) a disproportionate sensitivity to the 18O/16O ratio of water, mediated by isotopic equilibration between water and NO2-, as well as (2) kinetic isotope discrimination during O atom incorporation from molecular oxygen and water.	Water	146-151	NBL1, DAN family BMP antagonist	Homo sapiens	10-13
30605314-6	2019	Empirically, the NO3- 18O/16O ratios thus produced fortuitously converge near the 18O/16O ratio of water.	Water	99-104	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
30764501-3	2019	Herd main breed and feeding practices were included in a model to assess the effect of water provision category on farm average milk yield/cow/d.	Water	87-92	Weaning weight-maternal milk	Bos taurus	128-132
30484346-6	2019	Treating with furosemide (drinking water) for 11 days led to decreased urine pH in both wild-type (WT) and BK-beta4-knockout mice (BK-beta4-KO) with increased V-ATPase expression and elevated plasma aldosterone levels.	Water	35-40	potassium large conductance calcium-activated channel, subfamily M, beta member 4	Mus musculus	107-115
30670655-6	2019	AHL10 S314 phosphorylation was critical for restriction of plant growth under low-water potential stress and for regulation of jasmonic acid and auxin-related gene expression as well as expression of developmental regulators including Shootmeristemless These genes were also misregulated in hai1-2 AHL10 S314 phosphorylation was required for AHL10 complexes to form foci within the nucleoplasm, suggesting that S314 phosphorylation may control AHL10 association with the nuclear matrix or with other transcriptional regulators.	Water	82-87	AT hook motif DNA-binding family protein	Arabidopsis thaliana	0-5
30670655-6	2019	AHL10 S314 phosphorylation was critical for restriction of plant growth under low-water potential stress and for regulation of jasmonic acid and auxin-related gene expression as well as expression of developmental regulators including Shootmeristemless These genes were also misregulated in hai1-2 AHL10 S314 phosphorylation was required for AHL10 complexes to form foci within the nucleoplasm, suggesting that S314 phosphorylation may control AHL10 association with the nuclear matrix or with other transcriptional regulators.	Water	82-87	PP2C protein (Clade A protein phosphatases type 2C)	Arabidopsis thaliana	291-295
30670655-6	2019	AHL10 S314 phosphorylation was critical for restriction of plant growth under low-water potential stress and for regulation of jasmonic acid and auxin-related gene expression as well as expression of developmental regulators including Shootmeristemless These genes were also misregulated in hai1-2 AHL10 S314 phosphorylation was required for AHL10 complexes to form foci within the nucleoplasm, suggesting that S314 phosphorylation may control AHL10 association with the nuclear matrix or with other transcriptional regulators.	Water	82-87	AT hook motif DNA-binding family protein	Arabidopsis thaliana	298-303
30670655-6	2019	AHL10 S314 phosphorylation was critical for restriction of plant growth under low-water potential stress and for regulation of jasmonic acid and auxin-related gene expression as well as expression of developmental regulators including Shootmeristemless These genes were also misregulated in hai1-2 AHL10 S314 phosphorylation was required for AHL10 complexes to form foci within the nucleoplasm, suggesting that S314 phosphorylation may control AHL10 association with the nuclear matrix or with other transcriptional regulators.	Water	82-87	AT hook motif DNA-binding family protein	Arabidopsis thaliana	298-303
30670655-6	2019	AHL10 S314 phosphorylation was critical for restriction of plant growth under low-water potential stress and for regulation of jasmonic acid and auxin-related gene expression as well as expression of developmental regulators including Shootmeristemless These genes were also misregulated in hai1-2 AHL10 S314 phosphorylation was required for AHL10 complexes to form foci within the nucleoplasm, suggesting that S314 phosphorylation may control AHL10 association with the nuclear matrix or with other transcriptional regulators.	Water	82-87	AT hook motif DNA-binding family protein	Arabidopsis thaliana	298-303
30800291-1	2019	The alteration of water balance and related disorders has emerged as being strictly linked to the state of activation of the vasopressin-aquaporin-2 (vasopressin-AQP2) pathway.	Water	18-23	arginine vasopressin	Homo sapiens	125-136
30800291-3	2019	Conversely, non-osmotic release of vasopressin is associated with an increase in water permeability in the renal collecting duct, producing water retention and increasing the circulatory blood volume.	Water	81-86	arginine vasopressin	Homo sapiens	35-46
30800291-3	2019	Conversely, non-osmotic release of vasopressin is associated with an increase in water permeability in the renal collecting duct, producing water retention and increasing the circulatory blood volume.	Water	140-145	arginine vasopressin	Homo sapiens	35-46
30427219-2	2019	We investigated whether protein kinase C (PKC) and adenosine monophosphate kinase (AMPK) are involved in hypertonicity-regulated water permeability.	Water	129-134	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	51-81
30427219-2	2019	We investigated whether protein kinase C (PKC) and adenosine monophosphate kinase (AMPK) are involved in hypertonicity-regulated water permeability.	Water	129-134	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	83-87
30427219-9	2019	Blockade of AMPK with Compound C decreased hypertonicity-stimulated water permeability but did not alter phosphorylation of AQP2 at S256 and S261.	Water	68-73	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	12-16
30427219-10	2019	AICAR, an AMPK stimulator, caused a transient increase in osmotic water permeability and increased phosphorylation of AQP2 at S256.	Water	66-71	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	10-14
30427219-14	2019	AMPK activation promotes water reabsorption, but the mechanism remains to be determined.	Water	25-30	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	0-4
30448865-7	2019	Exposure to FB1 supplemented in the mice"s drinking water resulted in more pronounced hepatotoxicity in LXR-/- mice compared to LXR+/+ mice, as indicated by hepatic transaminase levels (ALT, AST) and hepatic inflammatory and fibrotic lesions.	Water	52-57	nuclear receptor subfamily 1, group H, member 3	Mus musculus	104-107
30515647-4	2019	However, very few data are available on PFAS contamination of wastewater and runoff water on such sites.	Water	67-72	phosphoribosylformylglycinamidine synthase	Homo sapiens	40-44
30415118-1	2019	We report an efficient screening procedure for the selective detection of compounds that are actively bound to estrogen receptor (ER) from environmental water samples using a receptor-mimic adsorbent prepared by a molecularly imprinted polymer (MIP).	Water	153-158	estrogen receptor 1	Homo sapiens	130-132
30408653-9	2019	The findings of this study advance knowledge on the DBP formation of GO in water treatment systems and provide insight on the toxic effects of the transformation products of GO.	Water	75-80	D-box binding PAR bZIP transcription factor	Homo sapiens	52-55
30788735-0	2019	Correlation between Urinary Excretion of Arginine-Vasopressin and Renal Reabsorption of Sodium and Water.	Water	99-104	arginine vasopressin	Rattus norvegicus	50-61
30788735-2	2019	In experiments on unanesthetized rats, water load (5 ml/100 g body weight) almost completely blocked secretion of arginine-vasopressin.	Water	39-44	arginine vasopressin	Rattus norvegicus	123-134
30788735-3	2019	Injection of arginine-vasopressin in a dose of 0.1 nmol/100 g body weight after water load enhanced reabsorption of solute-free water and renal excretion of Na+, K+, and Mg2+ by 13.3, 5.5, and 5.0 times, respectively; urinary excretion of Ca2+ remained unchanged.	Water	80-85	arginine vasopressin	Rattus norvegicus	22-33
30788735-3	2019	Injection of arginine-vasopressin in a dose of 0.1 nmol/100 g body weight after water load enhanced reabsorption of solute-free water and renal excretion of Na+, K+, and Mg2+ by 13.3, 5.5, and 5.0 times, respectively; urinary excretion of Ca2+ remained unchanged.	Water	128-133	arginine vasopressin	Rattus norvegicus	22-33
30788735-4	2019	It was found that urinary excretion of arginine-vasopressin directly correlated with reabsorption of solute-free water and renal sodium excretion.	Water	113-118	arginine vasopressin	Rattus norvegicus	48-59
30448750-2	2019	This study investigates the effects of different ions on DBP formation during chlorination and chloramination in artificial and real water samples.	Water	133-138	D-box binding PAR bZIP transcription factor	Homo sapiens	57-60
30415118-0	2019	Efficient extraction of estrogen receptor-active compounds from environmental surface water via a receptor-mimic adsorbent, a hydrophilic PEG-based molecularly imprinted polymer.	Water	86-91	estrogen receptor 1	Homo sapiens	24-41
29242971-2	2019	We tested if copeptin could be suppressed by increased water intake in healthy individuals, and if a water-induced change in copeptin was accompanied by altered concentrations of glucose, insulin or glucagon.	Water	101-106	insulin	Homo sapiens	188-195
30415118-1	2019	We report an efficient screening procedure for the selective detection of compounds that are actively bound to estrogen receptor (ER) from environmental water samples using a receptor-mimic adsorbent prepared by a molecularly imprinted polymer (MIP).	Water	153-158	estrogen receptor 1	Homo sapiens	111-128
30739527-1	2019	Aquaporin-1 (AQP1) is a homo-tetrameric transmembrane protein that facilitates rapid movement of water and ions across cell membranes.	Water	97-102	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
30739527-1	2019	Aquaporin-1 (AQP1) is a homo-tetrameric transmembrane protein that facilitates rapid movement of water and ions across cell membranes.	Water	97-102	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
30617890-3	2019	Concentrations of the seven target steroid hormones ranged from below the detection limit (ND) to 69.5 ng L-1 in the water of Chaohu Lake and the upstream rivers.	Water	117-122	immunoglobulin kappa variable 1-16	Homo sapiens	106-109
30391591-1	2019	Two water-soluble polysaccharides, BSP-1 and BSP-2, were extracted and purified from the tuber of Bletilla striata.	Water	4-9	kallikrein related-peptidase 8	Mus musculus	35-40
30468840-4	2019	Basic AFs (AFB1, AFB2, AFG1, and AFG2) are metabolized in the liver or by microbes that produce hydroxylated metabolites (AFM1, AFM2, and AFP1) and aflatoxicol (AFL), soluble in water and easy to dispose.	Water	178-183	spermatogenesis associated 5	Homo sapiens	33-37
30470864-1	2019	Major intrinsic protein (MIP) superfamily contains water-transporting AQP1 and glycerol-specific GlpF belonging to two major phylogenetic groups, namely aquaporins (AQPs) and aquaglyceroporins (AQGPs).	Water	51-56	aquaporin 1 (Colton blood group)	Homo sapiens	70-74
30508412-4	2019	The present results are the first to demonstrate that PKC/p38 MAPK signaling is involved in ANGII-induced water and sodium intake and oxytocin (OT) secretion in OVX rats.	Water	106-111	angiotensinogen	Rattus norvegicus	92-97
30519876-3	2019	ABCA1, ABCG1, and SR-B1 molecules contain 50, 19, and 13 Chol-binding motifs, respectively, that are localized either in membrane helices, or at membrane-water interface, or in water-exposed protein regions.	Water	154-159	ATP binding cassette subfamily G member 1	Homo sapiens	7-12
30519876-3	2019	ABCA1, ABCG1, and SR-B1 molecules contain 50, 19, and 13 Chol-binding motifs, respectively, that are localized either in membrane helices, or at membrane-water interface, or in water-exposed protein regions.	Water	177-182	ATP binding cassette subfamily G member 1	Homo sapiens	7-12
30391713-5	2019	A probabilistic mean of elevation values for all water-designated pixels (between 5% and 95% filled within each grid) produces lake water levels often accurate to within +-50 cm of gauged reference data on Lake Curuai in the Amazon River and Tonle Sap Lake along the Mekong River.	Water	132-137	SH2 domain containing 1A	Homo sapiens	248-251
30470864-8	2019	In contrast, the introduction of IHSB in the two AQP1 mutants has increased water transport.	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	49-53
30924801-8	2019	High adsorption capacity, reusability, fast kinetics and simple synthesis method indicate that prepared nanocomposite can be suggested as a high-performance adsorbent for Pb(II) removal from polluted water.	Water	200-205	submaxillary gland androgen regulated protein 3B	Homo sapiens	171-177
30073660-3	2019	RESULTS: In the above WPR range, the cooked pasta water uptake (1.3 +- 0.1 g g-1 ), cooking loss (0.037 +- 0.009 g g-1 ) and degree of starch gelatinization (11.2 +- 0.8%) were approximately constant, whereas the main Texture Analysis parameters (eg, cooked pasta hardness at 30% and 90% deformation, and resilience) showed no statistically significant difference.	Water	50-55	solute carrier family 45 member 1	Homo sapiens	44-49
30604254-4	2019	First, immunohistochemistry, immunofluorescence and electron microscopy showed that Atg5 and beta-catenin were highly expressed in human fibrotic liver and mouse liver injury induced by feeding a 50% choline-deficient diet plus 0.15% ethionine solution in drinking water (CDE diet) for 21 days; in addition, these factors were expressed in CK19-positive HPCs.	Water	265-270	autophagy related 5	Homo sapiens	84-88
31031250-3	2019	The results show that the spatial distribution of the snail populations is related to pH, dissolved oxygen (mg/l), conductivity, temperature (C), and water flow velocity (m/s).	Water	150-155	snail family transcriptional repressor 1	Homo sapiens	54-59
30446806-3	2019	In addition, CaSR increases water and proton excretion in the collecting duct and promotes phosphate reabsorption and citrate excretion in the proximal tubule.	Water	28-33	calcium sensing receptor	Homo sapiens	13-17
30657490-6	2019	Equally important is the fact that the position of both the conduction and valence band edges of the h-BCH sheet matches well with the chemical reaction potential of H2/H+ and O2/H2O, giving a 2D photocatalyst as a potential candidate for overall visible-light-driven water splitting.	Water	179-182	chimerin 2	Homo sapiens	103-106
30775200-4	2019	Because of the marked tendency of guanidium ions to interact with hydrophobic groups, a smaller number of water molecules were hydrated with hydrophobic groups in GdnHCl-denatured Cyt c than in urea-denatured Cyt c, resulting in the smaller positive DeltaV u.	Water	106-111	cytochrome c, somatic	Homo sapiens	180-185
30775200-4	2019	Because of the marked tendency of guanidium ions to interact with hydrophobic groups, a smaller number of water molecules were hydrated with hydrophobic groups in GdnHCl-denatured Cyt c than in urea-denatured Cyt c, resulting in the smaller positive DeltaV u.	Water	106-111	cytochrome c, somatic	Homo sapiens	209-214
30620176-6	2019	Thus, outstanding fog-harvesting efficiency was achieved on N3D, for example, probably reaching 865.1 kg/m2/day, where the mass of collected water within 2 h can raise up to over 240 times higher than the weight of an original 3D web without nanocones.	Water	141-146	zinc finger protein, FOG family member 1	Homo sapiens	18-21
30700259-7	2019	G6PD5 participates in the reduction of H2O2 to H2O in the ascorbate-glutathione cycle.	Water	39-42	glucose-6-phosphate dehydrogenase 5	Arabidopsis thaliana	0-5
30691231-2	2019	Selective loading of AH2 into the inner lumen of natural halloysite nanotubes (HNT) yields a composite nanoantioxidant (HNT/AH2), which was characterized and investigated for its reactivity with the persistent 1,1-diphenyl-2-picrylhydrazyl (DPPH ) radical and with transient peroxyl radicals in the inhibited autoxidation of organic substrates, both in organic solution (acetonitrile) and in buffered (pH 7.4) water in comparison with native AH2.	Water	410-415	zinc finger RANBP2-type containing 3	Homo sapiens	21-24
30709290-2	2019	Specifically, laser-induced fluorescence detection of NO(2Pi1/2, 3/2, v = 0, J) evaporating from an ~5 mM NO-water solution provides a detailed characterization of the rotational and spin-orbit distributions emerging from a  4-5 mum liquid microjet into vacuum.	Water	109-114	NBL1, DAN family BMP antagonist	Homo sapiens	54-68
30571108-8	2019	Unlike the water-free conformation I", three water molecules appear around Mg2+ in the water-occupied conformation I, which can finally exert an influence on the catalytic mechanism of Akt1.	Water	11-16	AKT serine/threonine kinase 1	Homo sapiens	185-189
30571108-8	2019	Unlike the water-free conformation I", three water molecules appear around Mg2+ in the water-occupied conformation I, which can finally exert an influence on the catalytic mechanism of Akt1.	Water	45-50	AKT serine/threonine kinase 1	Homo sapiens	185-189
30571108-8	2019	Unlike the water-free conformation I", three water molecules appear around Mg2+ in the water-occupied conformation I, which can finally exert an influence on the catalytic mechanism of Akt1.	Water	45-50	AKT serine/threonine kinase 1	Homo sapiens	185-189
30691231-4	2019	Reaction with peroxyl radicals has a rate constant of 1.4 x 106 M-1 s-1 and 5.1 x 104 M-1 s-1, respectively, in buffered water (pH 7.4) and acetonitrile, at 30  C. Results offer physical understanding of the factors governing HNT/AH2 reactivity.	Water	121-126	zinc finger RANBP2-type containing 3	Homo sapiens	230-233
30656855-3	2019	: A new member of the family Neisseriaceae isolated from laboratory tap water.	Water	72-77	SEC14 like lipid binding 2	Homo sapiens	68-71
30678081-6	2019	Focusing on the water-specific aquaporins (AQP0-AQP5), we discuss how gating and trafficking are controlled by phosphorylation and how phosphorylation affects the binding of aquaporins to regulatory proteins, thereby highlighting structural details and dissecting the contribution of individual phosphorylated residues when possible.	Water	16-21	major intrinsic protein of lens fiber	Homo sapiens	43-47
30656855-4	2019	A bacterial strain designated as P08T was isolated from laboratory tap water during a water quality assessment in University of Malaya, Malaysia.	Water	71-76	SEC14 like lipid binding 2	Homo sapiens	67-70
30368138-9	2019	Essentially, the findings of this first comprehensive report on the PCB contamination in the surface water in Bangladesh may provide a reference to future studies of these compounds in the Bay of Bengal.	Water	101-106	pyruvate carboxylase	Homo sapiens	68-71
30566121-0	2019	Electrochemical CO2 reduction in water at carbon cloth electrodes functionalized with a fac-Mn(apbpy)(CO)3Br complex.	Water	33-38	FA complementation group C	Homo sapiens	88-91
30787992-1	2019	Sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA, has been used in traditional Chinese medicine for many years.	Water	41-46	ATPase, class II, type 9A	Mus musculus	18-21
30199716-0	2019	Resonance light scattering sensor of the metal complex nanoparticles using diethyl dithiocarbamate doped graphene quantum dots for highly Pb(II)-sensitive detection in water sample.	Water	168-173	submaxillary gland androgen regulated protein 3B	Homo sapiens	138-145
30547581-6	2019	The treatment of a 6.7 nM NDMA-spiked surface water sample, under similar operating conditions (liquid residence time of 22 s), achieved 92 to 97% removal with permeate concentrations between 16 and 40 ng L-1.	Water	46-51	immunoglobulin kappa variable 1-16	Homo sapiens	205-208
30561985-4	2019	Here we show that fluorescence spectra predict both microcystin-LR occurrence and DBP formation potential (DBPfp) in lake water.	Water	122-127	D-box binding PAR bZIP transcription factor	Homo sapiens	82-85
30199716-7	2019	The proposed method was also proved with certified water sample containing 60 mug L-1 Pb2+ giving an excellent accuracy and was then implied satisfactorily for ultra-trace determination of Pb2+ in drinking water and tap water samples.	Water	51-56	L1 cell adhesion molecule	Homo sapiens	82-85
30641983-1	2019	In this work, we explore the protection with Nafion of commercial sputtered-bismuth screen-printed electrodes (BiSPSPEs), to improve its ability for on-site determination of Cd(II) and Pb(II) ions in ambient water samples.	Water	208-213	submaxillary gland androgen regulated protein 3B	Homo sapiens	174-191
30641983-6	2019	The values obtained for Pb(II) and Cd(II) in natural water samples agreed well with those obtained by the much more costly Inductively Coupled Plasma Mass Spectrometry, ICP-MS, technique as a reference method (recoveries from 75% to 111%).	Water	53-58	submaxillary gland androgen regulated protein 3B	Homo sapiens	24-30
30723756-1	2019	This data article proposes a mechanisms of Arsenic(III) removal from water using zeolite-reduced graphene oxide (ZrGO) composite.	Water	69-74	l(2)46Cc	Drosophila melanogaster	43-55
30543406-2	2019	Using a combination of experiments and high-fidelity molecular dynamics (MD) simulations, it is shown here that the hydrophilization of the sp2 carbon structure, induced by the presence of the C-N bonds, decreases the pure water permeance in CNNTs when compared with pristine and turbostratic carbon nanotubes (CNTs).	Water	223-228	Sp2 transcription factor	Homo sapiens	140-143
30180321-2	2019	In particular, nitrate concentrations exceeding the 50 mg L-1 limit established for drinking water pose the human health at risk.	Water	93-98	L1 cell adhesion molecule	Homo sapiens	58-61
30391337-2	2019	Milk has gained interest as a drug delivery system due to its ability to dissolve poorly water-soluble drugs.	Water	89-94	Weaning weight-maternal milk	Bos taurus	0-4
30391337-4	2019	Milk-drug tablets were formulated by blending freeze-dried bovine milk or infant formula with the poorly water-soluble drug cinnarizine, which were directly compressed.	Water	105-110	Weaning weight-maternal milk	Bos taurus	0-4
30391337-8	2019	These findings show that similar to the use of liquid milk, the formulation of milk-drug tablets can be used to improve solubilisation of poorly water-soluble drugs.	Water	145-150	Weaning weight-maternal milk	Bos taurus	79-83
30628261-3	2019	The mass concentration of water-soluble ions was (56.5+-25.7) mug m-3 and SO42-, NO3-, and NH4+ were the most dominant ions with a concentration of (13.6+-5.5), (21.4+-12.0), and (13.3+-5.7) mug m-3, respectively, accounting for 85.6% of the water-soluble ions.	Water	26-31	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
30628283-5	2019	When the raw water contained BSA molecules and the coagulant dosage was 0.16 mmol L-1, the flocs formed by PACl with Ca2+ were larger (~50 mum) than the flocs generated by PACl and the settleability also improved.	Water	13-18	immunoglobulin kappa variable 1-16	Homo sapiens	82-85
30713665-5	2018	As demonstrated by enzyme linked immunosorbent assay and 16S rDNA sequence analysis of stool samples, the consumption of hydrogen-rich water for two months significantly reduced serum malondialdehyde, interleukin-1, interleukin-6, tumour necrosis factor-alpha levels; then significantly increased serum superoxide dismutase, total antioxidant capacity levels and haemoglobin levels of whole blood.	Water	135-140	interleukin 6	Homo sapiens	216-259
30342014-1	2019	A water-soluble curcumin lysinate incorporated into hydroxypropyl-beta-cyclodextrin (NDS27) has been developed and shown anti-inflammatory properties but no comparative study has been made in parallel with its parent molecule, curcumin on polymorphonuclear neutrophils (PMNs) and myeloperoxidase (MPO) involved in inflammation.	Water	2-7	myeloperoxidase	Homo sapiens	280-295
30617620-1	2019	A quick and sensitive method was developed for the trace determination of Cd(II), Pb(II) and Cu(II) ions in water and bean samples.	Water	108-113	submaxillary gland androgen regulated protein 3B	Homo sapiens	82-88
30176414-9	2019	To summarize, these results represent the first fabrication of NZVI/AC composites with such low iron loading that still present an outstanding Pb(II) removal performance in drinking water purification.	Water	182-187	submaxillary gland androgen regulated protein 3B	Homo sapiens	143-149
30342014-1	2019	A water-soluble curcumin lysinate incorporated into hydroxypropyl-beta-cyclodextrin (NDS27) has been developed and shown anti-inflammatory properties but no comparative study has been made in parallel with its parent molecule, curcumin on polymorphonuclear neutrophils (PMNs) and myeloperoxidase (MPO) involved in inflammation.	Water	2-7	myeloperoxidase	Homo sapiens	297-300
30394213-0	2019	Exploring the Role of Water Molecules in the Ligand Binding Domain of PDE4B and PDE4D: Virtual Screening Based Molecular Docking of Some Active Scaffolds.	Water	22-27	phosphodiesterase 4B	Homo sapiens	70-75
30516368-2	2019	We report here the first case of a luminescent metal organic framework based probe (ThP-1) for highly sensitive and selective self-calibrated sensing of Th4+ contamination in natural fresh water media with a notably facilitated detection procedure.	Water	189-194	GLI family zinc finger 2	Homo sapiens	84-89
30431330-0	2019	Water intake increases mesenteric lymph flow and the total flux of albumin, long-chain fatty acids, and IL-22 in rats: new concept of absorption in jejunum.	Water	0-5	interleukin 22	Rattus norvegicus	104-109
30431330-5	2019	The intragastric administration of distilled water caused significant increases in rat mesenteric lymph flow and in the total flux of cells, albumin, long-chain fatty acids, and IL-22 through the lymph vessels.	Water	45-50	interleukin 22	Rattus norvegicus	178-183
30431330-11	2019	Water intake also accelerates the transfer of IL-22 to the mesenteric lymph, which may contribute, in part, to maintaining and promoting the innate immunity in the body.	Water	0-5	interleukin 22	Rattus norvegicus	46-51
30431330-14	2019	IL-22 released from the ILC-3 is also transported through mesenteric lymph in collaboration with the albumin-mediated movement of consumed water.	Water	139-144	interleukin 22	Rattus norvegicus	0-5
30257245-8	2019	Postradiotherapy treatment with different solutions (CHX, NaF, and EGCG) led to lower fluorescence intensity/mm2 in irradiated teeth than in the control group (distilled water; p < 0.05), as a result of MMP inactivation.	Water	170-175	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
31474736-4	2019	Molecular dynamics simulations were carried out to investigate the structure of Abeta complex in the hydrophobic solution composed of dioxane and water molecules.	Water	146-151	amyloid beta precursor protein	Homo sapiens	80-85
30914029-6	2019	Although the angiotensin II (AngII)/AT1 receptor system is best known for mediating blood pressure and body water/electrolyte balance it also facilitates tumor vascularization and growth by stimulating the expression of VEGF.	Water	108-113	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	13-27
30914029-6	2019	Although the angiotensin II (AngII)/AT1 receptor system is best known for mediating blood pressure and body water/electrolyte balance it also facilitates tumor vascularization and growth by stimulating the expression of VEGF.	Water	108-113	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	29-34
30718974-11	2019	CYP1A1 and CYP1A2 expressions increased after sanguinarine-containing solution, fulvic acid, and drinking water acidifier treatment.	Water	106-111	cytochrome P450 family 1 subfamily A member 1	Sus scrofa	0-6
30266019-3	2019	Bovine serum albumin (BSA) is a water soluble, biocompatible and non-toxic protein with a promising application in lipophilic bioactive compound delivery.	Water	32-37	albumin	Homo sapiens	7-20
31393245-6	2019	Threading of beta-CD over PEG-SA polyester axle was conducted in water, followed by end-capping of polypseudorotaxane using 2,4,6-trinitrobenzenesulfonic acid to yield polyester-based polyrotaxane.	Water	65-70	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	13-20
28161860-10	2019	The product distribution (i.e., the molar ratio of NO3- to NH4+) in water was different from that in urine because the negatively charged surface of TiO2 in urine attracts the positively charged area of carbamic acid (intermediate) and encourages its decomposition into NH4+ and not into NO3-.	Water	68-73	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
30657456-6	2019	The MW-exposed rats with silica-rich water (MW+EW) had lower serum tumor necrosis factor alpha (TNF-alpha) and interleukin 2 (IL-2) levels, but higher IL-10 levels, than MW+SW rats (p &lt; 0.05).	Water	37-42	tumor necrosis factor	Rattus norvegicus	67-94
30657456-7	2019	The higher TNF-alpha production by non-stimulated MW exposed PMs was ameliorated by the silica-rich water (p &lt; 0.01).	Water	100-105	tumor necrosis factor	Rattus norvegicus	11-20
30657456-8	2019	The MW exposition suppressed LPS potential for TNF-alpha synthesis in both water type groups, with greater suppression in animals that took standard water.	Water	75-80	tumor necrosis factor	Rattus norvegicus	47-56
30289450-2	2019	Claudin-2 is a junction protein that mediates paracellular water transport in epithelia.	Water	59-64	claudin 2	Homo sapiens	0-9
30366294-4	2019	Gas-phase and freely-dissolved water  PCB samples median were 4.0 ng m-3 and 14 ng L-1, both exhibiting increasing concentrations over the year of study, and with a strong positive correlation between them (R2 = 0.93 for  PCBs).	Water	31-36	pyruvate carboxylase	Homo sapiens	38-41
30366294-5	2019	The relative concentrations of individual PCB congeners were very similar between air and water samples, and resemble Aroclor 1248, a mixture previously reported to contaminate the IHSC sediments.	Water	90-95	pyruvate carboxylase	Homo sapiens	42-45
30366294-7	2019	Although different sampling methods were performed to estimate air-water fluxes between the month of August of 2006 and 2017,  PCB net fluxes have decreased by more than 60%, suggesting that either dredging at IHSC from 2012 to 2017 or reduction of upstream sources have decreased the freely-dissolved water concentrations of PCBs, thus reducing the air-water net volatilization in IHSC.	Water	302-307	pyruvate carboxylase	Homo sapiens	127-130
30366294-7	2019	Although different sampling methods were performed to estimate air-water fluxes between the month of August of 2006 and 2017,  PCB net fluxes have decreased by more than 60%, suggesting that either dredging at IHSC from 2012 to 2017 or reduction of upstream sources have decreased the freely-dissolved water concentrations of PCBs, thus reducing the air-water net volatilization in IHSC.	Water	302-307	pyruvate carboxylase	Homo sapiens	127-130
30366299-5	2019	Regardless, BADGE 2HCl and BADGE showed higher cytotoxicity than BADGE H2O, which was the only compound that significantly inhibited CYP19 activity (IC50 49 +- 5 muM).	Water	71-74	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	133-138
30366299-8	2019	The results evidence the ability of BADGE and derivatives to affect placental lipid handling and to modulate placental CYP19 activity (BADGE H2O) and highlights the need to monitor human exposure to these compounds, at least as intensely as BPA is monitored.	Water	141-144	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	119-124
31588538-5	2019	The hormone of water conservation is the vasopressin (AVP), and a large volume of urine is produced and excreted in the absence of AVP secretion or if AVP is ineffective in the kidneys.	Water	15-20	arginine vasopressin	Homo sapiens	41-52
31588538-5	2019	The hormone of water conservation is the vasopressin (AVP), and a large volume of urine is produced and excreted in the absence of AVP secretion or if AVP is ineffective in the kidneys.	Water	15-20	arginine vasopressin	Homo sapiens	54-57
31588538-6	2019	The aquaporin-2 water channel (AQP2) is expressed in the principal cells, and it plays an essential role in the reabsorption of water in the collecting ducts via type 2 vasopressin receptor (V2R)-mediated mechanism.	Water	16-21	arginine vasopressin receptor 2	Homo sapiens	162-194
31588538-6	2019	The aquaporin-2 water channel (AQP2) is expressed in the principal cells, and it plays an essential role in the reabsorption of water in the collecting ducts via type 2 vasopressin receptor (V2R)-mediated mechanism.	Water	128-133	arginine vasopressin receptor 2	Homo sapiens	162-194
32097916-4	2019	The key mechanism leading to solute-free water retention is a non-osmotic hypersecretion of vasopressin (AVP), secondary to a reduction in effective arterial blood pressure existing in patients with advanced cirrhosis.	Water	41-46	arginine vasopressin	Homo sapiens	92-103
32097945-5	2019	Central to this process is the now well-defined cellular pathway whereby vasopressin renders the collecting duct, water permeable.	Water	114-119	arginine vasopressin	Homo sapiens	73-84
30394213-9	2019	RESULTS: In presence of water molecule, Roflumilast has more binding affinity (-8.48 Kcal/mol with PDE4B enzyme and -8.91 Kcal/mol with PDE4D enzyme) and forms two hydrogen bonds with Gln443 and Glu369 and amino acid with PDE4B and PDE4D enzymes respectively.	Water	24-29	phosphodiesterase 4B	Homo sapiens	99-104
30394213-9	2019	RESULTS: In presence of water molecule, Roflumilast has more binding affinity (-8.48 Kcal/mol with PDE4B enzyme and -8.91 Kcal/mol with PDE4D enzyme) and forms two hydrogen bonds with Gln443 and Glu369 and amino acid with PDE4B and PDE4D enzymes respectively.	Water	24-29	phosphodiesterase 4B	Homo sapiens	222-227
30394213-10	2019	While in absence of water molecule its binding affinity has decreased (-7.3 Kcal/mol with PDE4B enzyme and -5.17 Kcal/mol with PDE4D enzyme) as well as no H-bond interactions were observed.	Water	20-25	phosphodiesterase 5A	Homo sapiens	90-109
30242840-15	2019	Our findings have mechanistic implications on the emerging use of vasopressin V2 receptor antagonists such as tolvaptan as safe and effective therapy for polycystic kidney disease and reveal a potential new regulator of transepithelial salt and water transport in the kidney.	Water	245-250	arginine vasopressin receptor 2	Homo sapiens	66-89
30321103-0	2019	Inhibition of Atherosclerotic Plaque Development by Oral Administration of alpha-Glucosyl Hesperidin and Water-Dispersible Hesperetin in Apolipoprotein E Knockout Mice.	Water	105-110	apolipoprotein E	Mus musculus	137-153
30321103-9	2019	CONCLUSIONS: Our study suggests that both alpha-glucosyl hesperidin and water-dispersible hesperetin exert protective effects on atherosclerotic progression in Apo-E KO mice because they exhibit hypolipidemic activity, reduce inflammation through macrophages, and prevent endothelial dysfunction.	Water	72-77	apolipoprotein E	Mus musculus	160-165
30270117-1	2019	BACKGROUND: Aquaporin-1 (AQP1), a water channel protein controlling the water contents of cells and tissues, exerts pleiotropic effects on various biological activities, including inflammation, angiogenesis, and extracellular matrix remodeling, by regulating cell behaviors and tissue water balance.	Water	34-39	aquaporin 1 (Colton blood group)	Homo sapiens	12-23
30270117-1	2019	BACKGROUND: Aquaporin-1 (AQP1), a water channel protein controlling the water contents of cells and tissues, exerts pleiotropic effects on various biological activities, including inflammation, angiogenesis, and extracellular matrix remodeling, by regulating cell behaviors and tissue water balance.	Water	34-39	aquaporin 1 (Colton blood group)	Homo sapiens	25-29
30377214-5	2019	In vivo evaluation of scratching behavior demonstrated that pharmacological inhibition of TRPV3 by forsythoside B significantly attenuated acute itch induced by either the TRPV3 agonist carvacrol or the pruritogen histamine, as well as chronic itch induced by acetone-ether-water in a mouse model of dry skin.	Water	274-279	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	90-95
30843458-6	2019	CONCLUSION:: Patients treated with an ACE inhibitor can latently experience inappropriate secretion of antidiuretic hormone, and rapidly develop severe hyponatremia together with additional factors affecting water or salt homeostasis regardless of the length of the administration duration.	Water	208-213	angiotensin I converting enzyme	Homo sapiens	38-41
30969409-2	2019	The molecular dynamics (MD) simulations are powerful computational tools to investigate molecular behavior of proteins and internal water molecules which are related to the function of proteins; however, the MD simulations of the rhodopsin require several technical setups for accurate calculations.	Water	132-137	rhodopsin	Homo sapiens	230-239
29057582-8	2019	Copeptin was significantly correlated with urinary and plasma osmolality, as well as free water clearance (r=0.43, 0.56 and -0.38 respectively; P &lt; .001 for all).	Water	90-95	arginine vasopressin	Homo sapiens	0-8
30516439-1	2019	The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for salt and water transport across epithelial cells.	Water	184-189	CF transmembrane conductance regulator	Homo sapiens	4-55
30341603-2	2019	The CF transmembrane conductance regulator (CFTR) is a plasma membrane ion channel, confined to apical membrane of epithelia, and ensures transepithelial water and solute movement across secretory epithelia in several organs.	Water	154-159	CF transmembrane conductance regulator	Homo sapiens	4-42
30341603-2	2019	The CF transmembrane conductance regulator (CFTR) is a plasma membrane ion channel, confined to apical membrane of epithelia, and ensures transepithelial water and solute movement across secretory epithelia in several organs.	Water	154-159	CF transmembrane conductance regulator	Homo sapiens	44-48
30516439-1	2019	The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for salt and water transport across epithelial cells.	Water	184-189	CF transmembrane conductance regulator	Homo sapiens	57-61
30507194-4	2018	In NO3 and BF4 systems, the effect of water-anion-water structures connected by hydrogen bonds due to the strong interaction of anion-water is large.	Water	38-43	NBL1, DAN family BMP antagonist	Homo sapiens	3-6
29595346-13	2019	And the pathways "SNARE interactions in vesicular transport" and "Vasopressin-regulated water reabsorption" were affected by cold storage in our study.	Water	88-93	arginine vasopressin	Homo sapiens	66-77
31178449-0	2019	Public Participation in Air Sampling and Water Quality Test Kit Development to Enable Citizen Science.	Water	41-46	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	60-63
31516170-2	2019	EAH has been reported in nearly every form of endurance activity and has a common pathogenic feature of excessive water intake which is usually coupled with elevated vasopressin levels.	Water	114-119	arginine vasopressin	Homo sapiens	166-177
31095130-9	2019	The antioxidant effect of mineral water was confirmed by the 14-20% decrease of the MDA concentration as well as by the increase of the catalase and superoxide dismutase (SOD) activities by 21-25% and 20-30% respectively in comparison with the control animals.	Water	34-39	catalase	Rattus norvegicus	136-144
30599750-3	2018	The mean square displacement in a water-ethanol mixture is greater than that anticipated from the macroscopic shear viscosity, indicating that the microscopic movement of Brownian motion involves the local information on the water-ethanol mixture on a molecular level, i.e., an inhomogeneity in the Brownian particle size (~1 mum).	Water	34-39	latexin	Homo sapiens	326-329
30599750-3	2018	The mean square displacement in a water-ethanol mixture is greater than that anticipated from the macroscopic shear viscosity, indicating that the microscopic movement of Brownian motion involves the local information on the water-ethanol mixture on a molecular level, i.e., an inhomogeneity in the Brownian particle size (~1 mum).	Water	225-230	latexin	Homo sapiens	326-329
30507194-4	2018	In NO3 and BF4 systems, the effect of water-anion-water structures connected by hydrogen bonds due to the strong interaction of anion-water is large.	Water	50-55	NBL1, DAN family BMP antagonist	Homo sapiens	3-6
30500160-2	2018	We examined the adsorption of a mAb (COE-3) at the SiO2/water interface in the presence of pentaethylene glycol monododecyl ether (C12E5), polysorbate 80 (PS80-20EO), and a polysorbate 80 analogue with seven ethoxylates (PS80-7EO).	Water	56-61	EBF transcription factor 3	Homo sapiens	37-42
30507194-4	2018	In NO3 and BF4 systems, the effect of water-anion-water structures connected by hydrogen bonds due to the strong interaction of anion-water is large.	Water	50-55	NBL1, DAN family BMP antagonist	Homo sapiens	3-6
30507194-7	2018	The relaxation time of the anion-water hydrogen bonds in the NO3 system is much longer than those in the other systems.	Water	33-38	NBL1, DAN family BMP antagonist	Homo sapiens	61-64
30507194-8	2018	It is the reason for the low water content dependency of the diffusion constants of the NO3 system.	Water	29-34	NBL1, DAN family BMP antagonist	Homo sapiens	88-91
30507194-9	2018	The water constant dependences of structures in NO3 and BF4 systems are similar, but that in the diffusion constant is not.	Water	4-9	NBL1, DAN family BMP antagonist	Homo sapiens	48-51
30100489-1	2018	Here, a solid/liquid phase extraction mode was used for the preconcentration of Pb(II) in water and food samples through a biomass reinforced graphene oxide (BGO) membrane.	Water	90-95	submaxillary gland androgen regulated protein 3B	Homo sapiens	80-86
30670930-9	2018	The fraction of peritoneal CD3+ B-1a cells decreased, and symptoms of the autoimmune disease were much milder in the distilled water-treated MRL/lpr mice.	Water	127-132	Fas (TNF receptor superfamily member 6)	Mus musculus	145-148
30433769-4	2018	Surface water and atmospheric concentrations were dominated by alpha-HCH (average 250 pg L-1 and 4.2 pg m-3, respectively), followed by HCB (average 17 pg L-1 and 89 pg m-3, respectively).	Water	8-13	immunoglobulin kappa variable 1-16	Homo sapiens	89-98
30327111-7	2018	It offers good accuracy when applied to analyze water samples, with relative recoveries ranging from 72 to 130%, for 4-octylphenol and 4-nonylphenol, respectively, and precision varying from 1 to 14.3%, for 4-nonylphenol at 1.0 mug L-1 and bisphenol A at 8.0 mug L-1, respectively.	Water	48-53	immunoglobulin kappa variable 1-16	Homo sapiens	232-235
30327111-7	2018	It offers good accuracy when applied to analyze water samples, with relative recoveries ranging from 72 to 130%, for 4-octylphenol and 4-nonylphenol, respectively, and precision varying from 1 to 14.3%, for 4-nonylphenol at 1.0 mug L-1 and bisphenol A at 8.0 mug L-1, respectively.	Water	48-53	immunoglobulin kappa variable 1-16	Homo sapiens	263-266
30461276-5	2018	The methodology is applied to water permeation through two representative membranes: a polymer of intrinsic microporosity (PIM-1) and a zeolitic imidazolate framework (ZIF-96).	Water	30-35	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	123-128
30461276-6	2018	For amorphous PIM-1 membrane, the predicted water permeability agrees perfectly with simulation.	Water	44-49	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-19
30489081-6	2018	Upon light exposure, rhodopsin is swollen by the penetration of water into the protein core, allowing interactions with effector proteins in the visual signaling mechanism.	Water	64-69	rhodopsin	Homo sapiens	21-30
30525164-2	2018	THz absorption spectra have been generated for CO2/H2O and CS2/H2O mixtures embedded in enriched solid para-H2 and numerous observed transitions associated with large-amplitude librational motion of the weakly bound binary CO2H2O and CS2H2O van der Waals cluster molecules have been assigned together with tentative assignments for the ternary CS2(H2O)2 system.	Water	51-54	chorionic somatomammotropin hormone 2	Homo sapiens	234-237
30525164-4	2018	It is suggested that even a less stable linear conformation of the ternary CS2(H2O)2 system, where one H2O molecule is linked to each S atom of the CS2 subunit, may be formed due to the kinetics associated with the mobility of free H2O molecules in the soft para-H2 medium.	Water	79-82	chorionic somatomammotropin hormone 2	Homo sapiens	75-78
30525164-4	2018	It is suggested that even a less stable linear conformation of the ternary CS2(H2O)2 system, where one H2O molecule is linked to each S atom of the CS2 subunit, may be formed due to the kinetics associated with the mobility of free H2O molecules in the soft para-H2 medium.	Water	79-82	chorionic somatomammotropin hormone 2	Homo sapiens	148-151
30525164-4	2018	It is suggested that even a less stable linear conformation of the ternary CS2(H2O)2 system, where one H2O molecule is linked to each S atom of the CS2 subunit, may be formed due to the kinetics associated with the mobility of free H2O molecules in the soft para-H2 medium.	Water	103-106	chorionic somatomammotropin hormone 2	Homo sapiens	75-78
30525164-4	2018	It is suggested that even a less stable linear conformation of the ternary CS2(H2O)2 system, where one H2O molecule is linked to each S atom of the CS2 subunit, may be formed due to the kinetics associated with the mobility of free H2O molecules in the soft para-H2 medium.	Water	103-106	chorionic somatomammotropin hormone 2	Homo sapiens	148-151
30525164-4	2018	It is suggested that even a less stable linear conformation of the ternary CS2(H2O)2 system, where one H2O molecule is linked to each S atom of the CS2 subunit, may be formed due to the kinetics associated with the mobility of free H2O molecules in the soft para-H2 medium.	Water	103-106	chorionic somatomammotropin hormone 2	Homo sapiens	75-78
30525164-4	2018	It is suggested that even a less stable linear conformation of the ternary CS2(H2O)2 system, where one H2O molecule is linked to each S atom of the CS2 subunit, may be formed due to the kinetics associated with the mobility of free H2O molecules in the soft para-H2 medium.	Water	103-106	chorionic somatomammotropin hormone 2	Homo sapiens	148-151
30212677-3	2018	Within the European Union, implementation of Directive 91/271/EEC is responsible for the location of wastewater treatment facilities in the territory, due to the requirement that all urban areas must have this infrastructure to reduce the environmental impact of treated water in water bodies.	Water	106-111	Ectrodactyly, ectodermal dysplasia, cleft lip/palate, 1	Homo sapiens	62-65
30245272-1	2018	In this work, the capability of the ionic liquid, 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)imide, [C2mim]FSI, to extract o-cresol, 2-chlorophenol, resorcinol and phenol from water, reaching the legal limit of 1 mg L-1 was analyzed.	Water	180-185	immunoglobulin kappa variable 1-16	Homo sapiens	220-223
30100489-6	2018	Furthermore, the method was successfully verified by analyzing spiked Pb(II) in water and food samples.	Water	80-85	submaxillary gland androgen regulated protein 3B	Homo sapiens	70-76
30312794-0	2018	Improved DBP elimination from swimming pool water by continuous combined UV and ozone treatment.	Water	44-49	D-box binding PAR bZIP transcription factor	Homo sapiens	9-12
30248879-6	2018	An initial target of 0.5 mg L-1 free chlorine ensured sufficient suppression of intact cells for up to 14 days (setting the time intervals for system flushes at times of low water usage).	Water	174-179	immunoglobulin kappa variable 1-16	Homo sapiens	28-31
30252476-6	2018	In both complexes, we observe significant changes in the water local density as the two proteins approach, supporting the existence of a clear dewetting transition in the case of MDM2-p53, with an onset distance of 5.6-7.6 A.	Water	57-62	tumor protein p53	Homo sapiens	184-187
30553262-0	2018	Calculation of the water-octanol partition coefficient of cholesterol for SPC, TIP3P, and TIP4P water.	Water	19-24	proline rich protein gene cluster	Homo sapiens	74-77
30444620-1	2018	The potential energy profiles of F/OH-induced nucleophilic substitution (SN2) and proton-transfer (PT) channels evolving with solvation for reactions of F-(H2O) n=1-2 + CH3I were characterized using B3LYP/ECP/d method.	Water	156-159	solute carrier family 38 member 5	Homo sapiens	73-76
30444620-8	2018	The water delivering process from fluorine to iodine side as illustrated on PES is barely observed, and instead, the reaction tends to dehydrate before passing through the SN2 barrier and proceeds with the less hydrated pathway in order to weaken the steric effect.	Water	4-9	solute carrier family 38 member 5	Homo sapiens	172-175
30881630-6	2019	Architectures that disassembled when CoII, ZnII and CdII templates were employed could be directly prepared from NiSO4 in water.	Water	122-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
30347126-6	2018	Upon exposure of AI SeC2 H compounds to water elemental selenium is formed again.	Water	40-45	fucosyltransferase 2	Homo sapiens	20-24
30361244-2	2018	There are currently alternative hypotheses that attempt to describe the abnormally viscous and elastic mucus that is a hallmark of CF airways disease, including: 1) loss of CF transmembrane regulator (CFTR)-dependent airway surface volume (water) secretion, producing mucus hyperconcentration-dependent increased viscosity, and 2) impaired bicarbonate secretion by CFTR, producing acidification of airway surfaces and increased mucus viscosity.A series of experiments was conducted to determine the contributions of mucus concentration versus pH to the rheological properties of airway mucus across length scales from the nanoscopic to macroscopic.For length scales greater than the nanoscopic, i.e. those relevant to mucociliary clearance, the effect of mucus concentration dominated over the effect of airway acidification.Mucus hydration and chemical reduction of disulfide bonds that connect mucin monomers are more promising therapeutic approaches than alkalisation.	Water	240-245	CF transmembrane conductance regulator	Homo sapiens	173-199
30291987-3	2018	Resiquimod is a small (water-soluble) agonist of the endosome-located Toll-like receptors 7 and 8 (TLR7/8).	Water	23-28	toll like receptor 7	Homo sapiens	70-97
30291987-3	2018	Resiquimod is a small (water-soluble) agonist of the endosome-located Toll-like receptors 7 and 8 (TLR7/8).	Water	23-28	toll like receptor 7	Homo sapiens	99-105
30422141-0	2018	Water-soluble MoS2 quantum dots for facile and sensitive fluorescence sensing of alkaline phosphatase activity in serum and live cells based on the inner filter effect.	Water	0-5	alkaline phosphatase, placental	Homo sapiens	81-101
30563134-5	2018	This empirical method focuses on the intensity of a specific neuroendocrine response (e.g., plasma arginine vasopressin (AVP) concentration) employed by the brain to regulate total body water volume and concentration.	Water	186-191	arginine vasopressin	Homo sapiens	108-119
30224129-7	2018	Water samples from city tap water and three rivers in Beijing are assessed using this technique, and the typical T&amp;O compositions are observed with concentrations ranging from 0.2 to 297 ng L-1.	Water	0-5	L1 cell adhesion molecule	Homo sapiens	194-197
30422643-2	2018	This strategy enables the sustained performance of copper catalysts in distilled and tap water electrolytes for over 12 h. The deposition of common electrolyte impurities such as iron, nickel, and zinc is blocked because EDTA can effectively bind the metal ions and negatively shift the electrode potential of M/M n+.	Water	89-94	SEC14 like lipid binding 2	Homo sapiens	85-88
30622665-12	2018	Filtered water treatment restored the activity of antioxidant enzymes, downregulated ET-1, and Ang II in the serum of mice.	Water	9-14	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	95-101
30622665-13	2018	Filtered water treatment suppressed proinflammatory cytokines and decreased the mRNA expression of TNF-alpha, IL-6, IL-1beta, and NF-kappaB P65.	Water	9-14	tumor necrosis factor	Mus musculus	99-108
30622665-13	2018	Filtered water treatment suppressed proinflammatory cytokines and decreased the mRNA expression of TNF-alpha, IL-6, IL-1beta, and NF-kappaB P65.	Water	9-14	interleukin 6	Mus musculus	110-114
30622665-13	2018	Filtered water treatment suppressed proinflammatory cytokines and decreased the mRNA expression of TNF-alpha, IL-6, IL-1beta, and NF-kappaB P65.	Water	9-14	interleukin 1 beta	Mus musculus	116-124
30266221-5	2018	Based on isotopic measurements, Edelman showed SNa level to be a function of exchangeable sodium and potassium divided by total-body water.	Water	133-138	snail family transcriptional repressor 1	Homo sapiens	47-50
30627556-16	2018	Furthermore, miR-15a-5p and miR-17-5p may function through "cell cycle, prostate cancer, and small cell lung cancer" while miR-19b-3p and miR-20a-5p function through "insulin resistance, hepatitis B, and viral carcinogenesis" and "vasopressin-regulated water reabsorption", respectively.	Water	253-258	insulin	Homo sapiens	167-174
30452863-3	2018	We employ a semi-artificial design, which wires a W-dependent formate dehydrogenase (FDH) cathode to a photoanode containing the photosynthetic water oxidation enzyme, Photosystem II, via a synthetic dye with complementary light absorption.	Water	144-149	aldehyde dehydrogenase 1 family member L1	Homo sapiens	85-88
30508456-1	2018	Annals Story Slam - Like Water, Like Wine.	Water	25-30	signaling lymphocytic activation molecule family member 1	Homo sapiens	13-17
31105260-1	2018	Here, we discuss the fabrication and problems of application of chitosan-based composite materials for the removal of hazardous metal ions from tap water and wastewater.	Water	148-153	SEC14 like lipid binding 2	Homo sapiens	144-147
31105260-5	2018	Investigations of the sorption performance of the composites have shown that they are efficient sorbents for 90Sr radionuclides uptake from tap water.	Water	144-149	SEC14 like lipid binding 2	Homo sapiens	140-143
30631351-7	2018	In addition, water extract of Phaleria macrocarpa and NAC significantly reduced the levels of MDA, TNF-alpha, and TGF-beta 1 as well as increasing the ratio of GSH/GSSG.	Water	13-18	tumor necrosis factor	Rattus norvegicus	99-108
30173142-0	2018	Effect of electroacupuncture on the activity of corticotrophin-releasing hormone neurons in the hypothalamus and amygdala in rats exposed to restraint water-immersion stress.	Water	151-156	corticotropin releasing hormone	Rattus norvegicus	48-80
30361244-2	2018	There are currently alternative hypotheses that attempt to describe the abnormally viscous and elastic mucus that is a hallmark of CF airways disease, including: 1) loss of CF transmembrane regulator (CFTR)-dependent airway surface volume (water) secretion, producing mucus hyperconcentration-dependent increased viscosity, and 2) impaired bicarbonate secretion by CFTR, producing acidification of airway surfaces and increased mucus viscosity.A series of experiments was conducted to determine the contributions of mucus concentration versus pH to the rheological properties of airway mucus across length scales from the nanoscopic to macroscopic.For length scales greater than the nanoscopic, i.e. those relevant to mucociliary clearance, the effect of mucus concentration dominated over the effect of airway acidification.Mucus hydration and chemical reduction of disulfide bonds that connect mucin monomers are more promising therapeutic approaches than alkalisation.	Water	240-245	CF transmembrane conductance regulator	Homo sapiens	201-205
29913320-7	2018	Moreover, when fish were reared in acidic water (pH = 4), ASIC4b knockdown led to a stimulation of Na+ uptake at 3 and 4 dpf, results which also were inconsistent with an essential role for ASIC-mediated Na+ uptake, even under conditions known to constrain Na+ uptake via NHE3b.	Water	42-47	acid-sensing (proton-gated) ion channel family member 4b	Danio rerio	58-64
30120669-4	2018	The resolution provided by qPCR facilitated assessment of the environmental and biological drivers of swimmer"s itch-causing cercariae concentrations, allowing us to demonstrate that cercarial abundance is greatest at the top of the water column, in locations with prevailing on- and alongshore winds.	Water	233-238	itchy E3 ubiquitin protein ligase	Homo sapiens	112-116
30189392-7	2018	Water extracts of both dust caused decrease of TEER value (39-73%), down-regulation of gene expression related to tight junction and mucin (0.2-0.8 fold), and loss of ZO-1 immunoreactivity from cellular borders, with office dust having greater potential than housedust to disrupt corneal epithelial barrier function.	Water	0-5	tight junction protein 1	Homo sapiens	167-171
30282851-6	2018	In the S-MP and C-MP, the amounts of water absorption did not differ significantly from those in the O-MP.	Water	37-42	matrilin 1, cartilage matrix protein	Mus musculus	16-20
30282851-8	2018	In contrast, C-MP retained its form even after water absorption.	Water	47-52	matrilin 1, cartilage matrix protein	Mus musculus	13-17
30228153-6	2018	RESULTS: Estradiol at age 21.5 and sex hormone-binding globulin at age 21.5 were positively associated with body mass index (BMI)-adjusted percent-water [RD (95% confidence interval (CI)): 3% (0%-7%) and 3% (1%-5%), respectively].	Water	147-152	sex hormone binding globulin	Homo sapiens	35-63
30228153-8	2018	Insulin-like growth factor-I and growth hormone at age 21.5 were also positively associated with BMI-adjusted percent-water [RD (95% CI): 2% (0%-4%) and 4% (1%-7%), respectively].	Water	118-123	insulin like growth factor 1	Homo sapiens	0-28
30228153-8	2018	Insulin-like growth factor-I and growth hormone at age 21.5 were also positively associated with BMI-adjusted percent-water [RD (95% CI): 2% (0%-4%) and 4% (1%-7%), respectively].	Water	118-123	growth hormone 1	Homo sapiens	33-47
30408861-1	2018	Hourly concentrations of water-soluble inorganic ions (Na+, NH4+, K+, Mg2+, Ca2+, Cl-, NO3- and SO42-) in PM2.5 and related reactive gases were measured with a Gas and Aerosol Collector combined with Ion Chromatography (GAC-IC) in urban Chengdu from April 17 to May 27, 2017, during which both haze and dust episodes occurred frequently.	Water	25-30	NBL1, DAN family BMP antagonist	Homo sapiens	87-90
30484159-0	2018	Water-based extracts of Zizania latifolia inhibit Staphylococcus aureus infection through the induction of human beta-defensin 2 expression in HaCaT cells.	Water	0-5	defensin beta 4A	Homo sapiens	113-128
30171943-2	2018	Three water-soluble polysaccharides, designated as CYZ, CYS-1, CYS-2, were purified and the molecular weight were found to be 22 KDa, 41 KDa and 23 KDa, respectively.	Water	6-11	cystin 1	Mus musculus	56-61
30172819-4	2018	More importantly, a Pb(II) removal efficiency of &gt;70% could be achieved after 6x adsorbent recycling, which demonstrated the excellent potential of McAPT@Alg for removing Pb(II) from contaminated water.	Water	199-204	submaxillary gland androgen regulated protein 3B	Homo sapiens	20-26
30172819-4	2018	More importantly, a Pb(II) removal efficiency of &gt;70% could be achieved after 6x adsorbent recycling, which demonstrated the excellent potential of McAPT@Alg for removing Pb(II) from contaminated water.	Water	199-204	submaxillary gland androgen regulated protein 3B	Homo sapiens	174-180
30317029-7	2018	24-753 mBq L-1 uranium activity concentrations were found in groundwater and surface water showing great areal variability.	Water	67-72	immunoglobulin kappa variable 1-16	Homo sapiens	11-14
29736983-7	2018	Oil-in-water emulsions of modified SPI had smaller droplet sizes and better creaming stability compared to those from unmodified SPI.	Water	7-12	chromogranin A	Homo sapiens	35-38
30274080-3	2018	Amphotericin B (AMP) is one such therapeutic molecule which requires protection as it possesses inherent limitations of poor water-solubility, susceptibility to oxidation- and/or light-induced degradation etc.	Water	125-130	adenine phosphoribosyltransferase	Homo sapiens	16-19
30599677-5	2018	However, in water, fluid-structure-interaction effects can increase attenuation dramatically to over 77 dB m-1 for a steel-walled channel, with a reduction in phase-speed approaching 70%.	Water	12-17	myoregulin	Homo sapiens	107-110
30274124-7	2018	Finally the hydrogels, which are 95-99% water, were shown to retain the high stability of the native Caf1 protein in a range of aqueous conditions, including extended immersion in cell culture media.	Water	40-45	F1 capsule antigen	Yersinia pestis	101-105
30266683-2	2018	Aquaporin 9 (AQP9) is an aquaglyceroporin membrane channel shown biophysically to conduct water, glycerol, and other small solutes.	Water	90-95	aquaporin 9	Rattus norvegicus	0-11
30538315-0	2018	Geckos slap their feet and swish their tails to race over water.	Water	58-63	Src like adaptor	Homo sapiens	7-11
30266683-2	2018	Aquaporin 9 (AQP9) is an aquaglyceroporin membrane channel shown biophysically to conduct water, glycerol, and other small solutes.	Water	90-95	aquaporin 9	Rattus norvegicus	13-17
30172535-4	2018	The use of modified paper filters for fast extraction and enrichment of the target substance from water samples results in a lower limit of detection of 0.19 microg L-1.	Water	98-103	immunoglobulin kappa variable 1-16	Homo sapiens	165-168
30411639-6	2018	Molecular dynamics simulation studies show that in free-form BRD4 the reported conserved water molecules are not retained at their specific positoins due to flexibiliy in the ZA-loop.	Water	89-94	bromodomain containing 4	Homo sapiens	61-65
30411639-7	2018	In BRD4-ligand complexes the number and positions of conserved water molecules depends on the bound ligand.	Water	63-68	bromodomain containing 4	Homo sapiens	3-7
30411639-8	2018	Identified potential inhibitors bind stably at the acetyl-lysine binding pocket of BRD4 and form direct and water-mediated hydrogen bonds with higher occupancy which may contribute to ligand specificity towards BRD4-BD1.	Water	108-113	bromodomain containing 4	Homo sapiens	83-87
30411639-8	2018	Identified potential inhibitors bind stably at the acetyl-lysine binding pocket of BRD4 and form direct and water-mediated hydrogen bonds with higher occupancy which may contribute to ligand specificity towards BRD4-BD1.	Water	108-113	bromodomain containing 4	Homo sapiens	211-215
30411639-8	2018	Identified potential inhibitors bind stably at the acetyl-lysine binding pocket of BRD4 and form direct and water-mediated hydrogen bonds with higher occupancy which may contribute to ligand specificity towards BRD4-BD1.	Water	108-113	defensin beta 1	Homo sapiens	216-219
30454615-13	2018	By combining target prediction and examination, we identified AQP2 as the direct mechanistic target of miR-137 that affected the water permeability of vaginal epithelial cells.	Water	129-134	microRNA 137	Homo sapiens	103-110
30350450-0	2018	Efficacy of nano-particulated, water-soluble erlotinib against intracranial metastases of EGFR-mutant lung cancer.	Water	31-36	epidermal growth factor receptor	Homo sapiens	90-94
30350450-3	2018	Here, we investigated the efficacy of water-soluble erlotinib (NUFS-sErt) against these metastases.	Water	38-43	solute carrier family 6 member 4	Homo sapiens	68-72
30350450-9	2018	Hence, our current findings indicate that NUFS-sErt is a novel, water-soluble form of erlotinib that can be administered using intraventricular or intrathecal injections.	Water	64-69	solute carrier family 6 member 4	Homo sapiens	47-51
30584753-10	2018	These might eventually result in the accumulation of NH4+ and reduction of NO3- in water, producing an impact on the microbial diversity.	Water	83-88	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
30406234-1	2018	Freezing processes are reported for pure-water droplets generated in a vacuum in the size range of 49-71 mum in diameter.	Water	41-46	latexin	Homo sapiens	105-108
30699079-4	2018	In this research, a field NH2Cl dissipation test was conducted with continuous tap water discharge into a storm sewer.	Water	83-88	SEC14 like lipid binding 2	Homo sapiens	79-82
30138958-3	2018	METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3).	Water	56-61	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
30138958-3	2018	METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3).	Water	163-168	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
30138958-3	2018	METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3).	Water	163-168	Src like adaptor	Homo sapiens	216-220
30138958-3	2018	METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3).	Water	163-168	NBL1, DAN family BMP antagonist	Homo sapiens	289-292
30325380-0	2018	Redox active ligand and metal cooperation for C(sp2)-H oxidation: extension of the galactose oxidase mechanism in water-mediated amide formation.	Water	114-119	Sp2 transcription factor	Homo sapiens	46-51
30339747-10	2018	Chlorination of ICM-containing source water increased I-DBP concentrations but not mutagenicity, indicating that such I-DBPs were either not mutagenic or at concentrations too low to affect mutagenicity.	Water	38-43	D-box binding PAR bZIP transcription factor	Homo sapiens	56-59
29991464-11	2018	Conclusion: p.H80Y mutation will cause inappropriate folding of the protein compromising water homeostasis via AVPR2 and AVP and leading to diabetes insipidus.	Water	89-94	arginine vasopressin receptor 2	Homo sapiens	111-116
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Water	114-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Water	114-117	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	214-217
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Water	114-117	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	226-229
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Water	201-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Water	201-206	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	214-217
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Water	201-206	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	226-229
30475879-0	2018	Antibiotic-resistant indicator bacteria in irrigation water: High prevalence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli.	Water	54-59	EsbL	Escherichia coli	114-118
31458227-5	2018	The sensitivity of the overall analytical method was enhanced by a very simple solid-phase extraction with C18 membranes, to be able to successfully apply it to natural water samples tested as real matrices.	Water	169-174	Bardet-Biedl syndrome 9	Homo sapiens	107-110
31458229-3	2018	Although Vit C is situated at subsurface beneath SA molecules and interacts via hydrogen bonding between the hydroxyl groups of Vit C and SA, several Vit C molecules may infiltrate within SA two-dimensional matrix at the air-water interface.	Water	225-230	vitrin	Homo sapiens	9-12
31458229-4	2018	The increased mole fraction of Vit C (0.125-0.5) and the reduction of temperature (from 22 to 10  C) of the subphase water result in an increase in the amount of adsorbed Vit C at the air-water interface.	Water	117-122	vitrin	Homo sapiens	171-174
31458229-4	2018	The increased mole fraction of Vit C (0.125-0.5) and the reduction of temperature (from 22 to 10  C) of the subphase water result in an increase in the amount of adsorbed Vit C at the air-water interface.	Water	188-193	vitrin	Homo sapiens	31-34
31458229-4	2018	The increased mole fraction of Vit C (0.125-0.5) and the reduction of temperature (from 22 to 10  C) of the subphase water result in an increase in the amount of adsorbed Vit C at the air-water interface.	Water	188-193	vitrin	Homo sapiens	171-174
30339752-0	2018	Charge-Controlled Surface Properties of Native and Fluorophore-Labeled Bovine Serum Albumin at the Air-Water Interface.	Water	103-108	albumin	Homo sapiens	78-91
30458729-7	2018	CONCLUSION: Using two non-invasive methods, 1H-MRS and T2 MR imaging, as well as in vitro brain-water content measurements, we demonstrated that the mechanism underlying the neuroprotective effects of GCP II-KO against brain swelling in TBI involves changes in glutamate and N-acetylaspartate levels.	Water	96-101	folate hydrolase 1	Mus musculus	201-207
30463221-10	2018	Ir-1 has no substitution on its phenyl group, a water molecule (like cisplatin) can replace its chloride ion and, hence, the rate of hydrolysis might be tuned by the substituent on the ligand system.	Water	48-53	immune response 1	Mus musculus	0-4
30077149-1	2018	The objective of this research was to explore the fundamental reactions between chlorine/chloramine and 2-hydroxyl-4-methoxyl benzophenone (BP3)/2-hydroxyl-4-methoxyl benzophenone-sulfonic acid (BP4), which were the most common reactions in benzophenone-type UV filters during drinking water treatment processes.	Water	286-291	BP3	Homo sapiens	140-143
30077149-1	2018	The objective of this research was to explore the fundamental reactions between chlorine/chloramine and 2-hydroxyl-4-methoxyl benzophenone (BP3)/2-hydroxyl-4-methoxyl benzophenone-sulfonic acid (BP4), which were the most common reactions in benzophenone-type UV filters during drinking water treatment processes.	Water	286-291	BP4	Homo sapiens	195-198
30456862-5	2018	A water-soluble fraction of urban dust (UD-WS) induces pro-inflammatory cytokine release (IL-8) from NHEKs (measured via ELISA).	Water	2-7	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
30339752-3	2018	Native and fluorescein isothiocyanate-labeled bovine serum albumin (BSA) were used to modify air-water interfaces as a function of pH.	Water	97-102	albumin	Homo sapiens	53-66
30350696-1	2018	Activated carbon (AC) is a carbonaceous material broadly applied in filters to remove lead (Pb(II)) from drinking water through adsorption.	Water	114-119	submaxillary gland androgen regulated protein 3B	Homo sapiens	92-98
30872874-0	2018	Calorimetric studies of interactions between low molecular weight salts and bovine serum albumin in water at pH values below and above the isoionic point.	Water	100-105	albumin	Homo sapiens	83-96
29920463-4	2018	The recirculation of lagoon water through sediments represents a source of NH4+ (1900-5500 mol d-1) and PO43- (22-71 mol d-1), but acts as a sink of NO3-.	Water	28-33	NBL1, DAN family BMP antagonist	Homo sapiens	149-152
30441879-5	2018	TPUs prepared using PEG with Mn of 10 kg/mol (PCL5-PEG10-PCL5) took up 534% water and were more flexible.	Water	76-81	paternally expressed 10	Homo sapiens	51-56
30473629-0	2018	Water-pipe smoking promotes epithelial-mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways.	Water	0-5	mitogen-activated protein kinase 3	Homo sapiens	108-112
30473629-0	2018	Water-pipe smoking promotes epithelial-mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways.	Water	0-5	mitogen-activated protein kinase 1	Homo sapiens	113-117
30085380-3	2018	We aimed to develop a novel method for the simple and rapid measurement of the delta15 N value of NO3 - in water.	Water	107-112	NBL1, DAN family BMP antagonist	Homo sapiens	98-101
30085380-4	2018	METHODS: Water NO3 - was transformed into nitrobenzene for nitrogen isotopic analysis by gas chromatography-combustion-isotope ratio mass spectrometry (GC/C-IRMS).	Water	9-14	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
30085380-12	2018	The GC/C-IRMS derivatization method offers a fully operational tool for delta15 N measurement of NO3 - in water.	Water	106-111	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
30382263-6	2018	Results show the poor efficiency of long chain fatty acid (C16, C18) monolayers in templating freezing of pure water droplets and seawater subphase to temperatures of at least -30  C, consistent with theory.	Water	111-116	Bardet-Biedl syndrome 9	Homo sapiens	64-67
30350696-9	2018	Overall, this work presents a new set of chemical reactions at the solid-liquid interface between Pb(II) and AC under various conditions of interest for the application of AC or other carbonaceous materials in water treatment.	Water	210-215	submaxillary gland androgen regulated protein 3B	Homo sapiens	98-104
30413033-10	2018	Additionally, the CS2 provided acceptable simulations of water quality, with the NSE values of 0.50 and 0.74 for calibration and validation periods, respectively.	Water	57-62	chorionic somatomammotropin hormone 2	Homo sapiens	18-21
31458193-3	2018	However, two isostructural monomeric complexes are formed {[M(HCPCA)2(H2O)2], M = Co(II), (2) and Mn(II) (3)} when reactions were carried out in the absence of dmphen.	Water	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
30295465-3	2018	Taking advantage of the fast and quantitative disproportionation of Cu(I)X in water, SET-LRP in organic solvent/water mixtures rids the organic solvent of mediating this fundamental event.	Water	78-83	LDL receptor related protein 1	Homo sapiens	89-92
30295465-3	2018	Taking advantage of the fast and quantitative disproportionation of Cu(I)X in water, SET-LRP in organic solvent/water mixtures rids the organic solvent of mediating this fundamental event.	Water	112-117	LDL receptor related protein 1	Homo sapiens	89-92
30295465-4	2018	Here, the Cu(0) wire-catalyzed SET-LRP synthesis of well-defined poly(methyl acrylate)s and poly(butyl acrylate)s with narrow molecular weight distribution and near perfect bromine chain end functionality is reported in HFIP/water mixtures.	Water	225-230	LDL receptor related protein 1	Homo sapiens	35-38
30467540-0	2018	Analysis of Interaction Between Interfacial Structure and Fibrinogen at Blood-Compatible Polymer/Water Interface.	Water	97-102	fibrinogen beta chain	Homo sapiens	58-68
30628207-3	2018	The results showed that the average concentration of water-soluble ions in Zhengzhou City was (70.9+-52.1) mug m-3 during the sampling period, and the order of water-soluble ion mass concentrations was NO3- &gt; SO42- &gt; NH4+ &gt; Ca2+ &gt; Na+ &gt; Cl- &gt; Mg2+ &gt; K+ &gt; F-; NO3-, SO42-, and NH4+ accounted for 79.9% of total water-soluble ions.	Water	160-165	NBL1, DAN family BMP antagonist	Homo sapiens	202-205
30467540-7	2018	The non-adsorption of FNG into the water rich domains was also clarified through topographic and phase image analyses.	Water	35-40	fibrinogen beta chain	Homo sapiens	22-25
30628223-11	2018	According to the criteria of the National Standard of Surface Water Quality of China, DEHP and DBP have limiting values of 8 mug L-1 and 3 mug L-1, respectively.	Water	62-67	D-box binding PAR bZIP transcription factor	Homo sapiens	95-98
30467540-9	2018	Water molecules in the water-rich domains are anticipated to be the dominant factor in preventing FNG adsorption and thrombogenesis on a PMEA interface.	Water	0-5	fibrinogen beta chain	Homo sapiens	98-101
30467540-9	2018	Water molecules in the water-rich domains are anticipated to be the dominant factor in preventing FNG adsorption and thrombogenesis on a PMEA interface.	Water	23-28	fibrinogen beta chain	Homo sapiens	98-101
30628207-3	2018	The results showed that the average concentration of water-soluble ions in Zhengzhou City was (70.9+-52.1) mug m-3 during the sampling period, and the order of water-soluble ion mass concentrations was NO3- &gt; SO42- &gt; NH4+ &gt; Ca2+ &gt; Na+ &gt; Cl- &gt; Mg2+ &gt; K+ &gt; F-; NO3-, SO42-, and NH4+ accounted for 79.9% of total water-soluble ions.	Water	160-165	NBL1, DAN family BMP antagonist	Homo sapiens	202-205
30628223-11	2018	According to the criteria of the National Standard of Surface Water Quality of China, DEHP and DBP have limiting values of 8 mug L-1 and 3 mug L-1, respectively.	Water	62-67	immunoglobulin kappa variable 1-16	Homo sapiens	129-138
30628223-11	2018	According to the criteria of the National Standard of Surface Water Quality of China, DEHP and DBP have limiting values of 8 mug L-1 and 3 mug L-1, respectively.	Water	62-67	immunoglobulin kappa variable 1-16	Homo sapiens	129-132
30320332-1	2018	Water droplet transport on fibers is of great importance for achieving high water collection efficiency from fog.	Water	0-5	zinc finger protein, FOG family member 1	Homo sapiens	109-112
30405071-9	2018	The water and ethanol FZ extracts exert cardiotoxic effects via activating the PI3K/Akt/mTOR signaling pathway to induce cardiomyocyte apoptosis.	Water	4-9	AKT serine/threonine kinase 1	Rattus norvegicus	84-87
30320332-1	2018	Water droplet transport on fibers is of great importance for achieving high water collection efficiency from fog.	Water	76-81	zinc finger protein, FOG family member 1	Homo sapiens	109-112
30320332-6	2018	Finally, the water collection rate from fog on uncoated microfibers over a prolonged duration is found to be improved over 2 times after superhydrophobic coating, and it is further enhanced over 5 times after a small tilting angle of 5 .	Water	13-18	zinc finger protein, FOG family member 1	Homo sapiens	40-43
30325362-3	2018	The scaling-MW2D confirmed that the water absorption of MXD6 comprises two processes, designated process I (2.0-12.0 min) and process II (12.0-27.0 min).	Water	36-41	MAX network transcriptional repressor	Homo sapiens	56-60
30325362-5	2018	Process I is the process of water plasticizing MXD6, which primarily consists of hydrophilic groups forming hydrogen bonds with water molecules and the hydration of hydrophobic groups.	Water	28-33	MAX network transcriptional repressor	Homo sapiens	47-51
30325362-5	2018	Process I is the process of water plasticizing MXD6, which primarily consists of hydrophilic groups forming hydrogen bonds with water molecules and the hydration of hydrophobic groups.	Water	128-133	MAX network transcriptional repressor	Homo sapiens	47-51
30325362-6	2018	Process II is the strong crystallization of MXD6 induced by water molecules, entailing the generation of the double hydrogen bond and the rearrangement of hydrophilic groups into the crystal lattice.	Water	60-65	MAX network transcriptional repressor	Homo sapiens	44-48
30325362-8	2018	Therefore, the reason for the barrier performance decline of the MXD6 film being significantly smaller than that of the PA6 film is that water molecules induced a large amount of new crystalline regions in the MXD6 matrix during plasticization.	Water	137-142	MAX network transcriptional repressor	Homo sapiens	65-69
30325362-8	2018	Therefore, the reason for the barrier performance decline of the MXD6 film being significantly smaller than that of the PA6 film is that water molecules induced a large amount of new crystalline regions in the MXD6 matrix during plasticization.	Water	137-142	MAX network transcriptional repressor	Homo sapiens	210-214
30159998-4	2018	The significant changes in geometry induced by a relatively mild temperature increase underline the importance of temperature for the shape and all properties influenced by this shape of hydrogen-bonded clusters of water ice.	Water	215-220	carboxylesterase 2	Homo sapiens	221-224
30320850-0	2018	Improved ATR-FTIR detection of hydrocarbons in water with semi-crystalline polyolefin coatings on ATR elements.	Water	47-52	ATR serine/threonine kinase	Homo sapiens	9-12
30320850-0	2018	Improved ATR-FTIR detection of hydrocarbons in water with semi-crystalline polyolefin coatings on ATR elements.	Water	47-52	ATR serine/threonine kinase	Homo sapiens	98-101
30320850-4	2018	Hydrophobic polymer coatings have been widely used to concentrate hydrocarbons for attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) detection at the surface of an ATR crystal by preventing water molecules from penetrating into the polymer coating while absorbing hydrocarbons.	Water	219-224	ATR serine/threonine kinase	Homo sapiens	152-155
30320850-4	2018	Hydrophobic polymer coatings have been widely used to concentrate hydrocarbons for attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) detection at the surface of an ATR crystal by preventing water molecules from penetrating into the polymer coating while absorbing hydrocarbons.	Water	219-224	ATR serine/threonine kinase	Homo sapiens	193-196
30320850-7	2018	The ATR signal is enhanced by the polymer coating which swells in response to the hydrocarbons and prevents water accumulation at the IR detection interface.	Water	108-113	ATR serine/threonine kinase	Homo sapiens	4-7
30519270-0	2018	Manilkara zapota (L.) P. Royen Leaf Water Extract Induces Apoptosis in Human Hepatocellular Carcinoma (HepG2) Cells via ERK1/2/Akt1/JNK1 Signaling Pathways.	Water	36-41	mitogen-activated protein kinase 3	Homo sapiens	120-126
30519270-0	2018	Manilkara zapota (L.) P. Royen Leaf Water Extract Induces Apoptosis in Human Hepatocellular Carcinoma (HepG2) Cells via ERK1/2/Akt1/JNK1 Signaling Pathways.	Water	36-41	AKT serine/threonine kinase 1	Homo sapiens	127-131
30519270-0	2018	Manilkara zapota (L.) P. Royen Leaf Water Extract Induces Apoptosis in Human Hepatocellular Carcinoma (HepG2) Cells via ERK1/2/Akt1/JNK1 Signaling Pathways.	Water	36-41	mitogen-activated protein kinase 8	Homo sapiens	132-136
30519270-8	2018	Overall analyses revealed that Manilkara zapota leaf water extract can increase percentage of early apoptotic cells, induce the formation of ROS, upregulate c-Jun N-terminal kinase 1 (JNK1) and inducible nitric oxide synthase (iNOS), and reduce Akt1 and vascular endothelial growth factor A (VEGFA) transcriptional activities.	Water	53-58	mitogen-activated protein kinase 8	Homo sapiens	184-188
30519270-8	2018	Overall analyses revealed that Manilkara zapota leaf water extract can increase percentage of early apoptotic cells, induce the formation of ROS, upregulate c-Jun N-terminal kinase 1 (JNK1) and inducible nitric oxide synthase (iNOS), and reduce Akt1 and vascular endothelial growth factor A (VEGFA) transcriptional activities.	Water	53-58	AKT serine/threonine kinase 1	Homo sapiens	245-249
30223332-2	2018	In this paper, the performance of UV/chlorine was compared with that of chlorine and UV to degrade GSM (100 ng L-1) and 2-MIB (100 ng L-1) in water.	Water	142-147	immunoglobulin kappa variable 1-16	Homo sapiens	111-114
29859962-1	2018	BACKGROUND: Selenophosphate, the key selenium donor for the synthesis of selenoprotein and selenium-modified tRNA, is produced by selenophosphate synthetase (SPS) from ATP, selenide, and H2O.	Water	187-190	selenophosphate synthetase 1	Homo sapiens	130-156
29859962-1	2018	BACKGROUND: Selenophosphate, the key selenium donor for the synthesis of selenoprotein and selenium-modified tRNA, is produced by selenophosphate synthetase (SPS) from ATP, selenide, and H2O.	Water	187-190	selenophosphate synthetase 1	Homo sapiens	158-161
30048934-0	2018	Drinking water disinfection byproduct iodoacetic acid interacts with catalase and induces cytotoxicity in mouse primary hepatocytes.	Water	9-14	catalase	Mus musculus	69-77
30185826-5	2018	We conclude based on the consistent part of the datasets that the core/dimerization domain of Bax (Bak) is water exposed with only helices 4 and 5 in membrane contact, whereas the piercing/latch domain is in peripheral membrane contact, with helix 9 being transmembrane.	Water	107-112	BCL2 associated X, apoptosis regulator	Homo sapiens	94-97
30031348-0	2018	What is driving the NF-kappaB response in environmental water extracts?	Water	56-61	nuclear factor kappa B subunit 1	Homo sapiens	20-29
30031348-2	2018	The NF-kappaB assay is responsive to surface water and wastewater extracts, but the causative compounds are unknown and micropollutants typically found in water do not activate the NF-kappaB assay.	Water	45-50	nuclear factor kappa B subunit 1	Homo sapiens	4-13
30031348-2	2018	The NF-kappaB assay is responsive to surface water and wastewater extracts, but the causative compounds are unknown and micropollutants typically found in water do not activate the NF-kappaB assay.	Water	60-65	nuclear factor kappa B subunit 1	Homo sapiens	4-13
30031348-3	2018	The current study aimed to investigate if co-extracted organic matter and/or endotoxins could cause the NF-kappaB response in surface water extracts.	Water	134-139	nuclear factor kappa B subunit 1	Homo sapiens	104-113
30031348-6	2018	All water extracts showed a response in the NF-kappaB assay, but the detected micropollutants could not explain the effect.	Water	4-9	nuclear factor kappa B subunit 1	Homo sapiens	44-53
30223332-2	2018	In this paper, the performance of UV/chlorine was compared with that of chlorine and UV to degrade GSM (100 ng L-1) and 2-MIB (100 ng L-1) in water.	Water	142-147	immunoglobulin kappa variable 1-16	Homo sapiens	134-137
30267750-7	2018	AngII significantly increased water intake and SABP (p &lt; .05).	Water	30-35	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-5
29182412-11	2018	Vasopressin-regulated changes in aquaporin channels may potentially partially explain the mechanism of increased body water loss with water loading.	Water	118-123	arginine vasopressin	Homo sapiens	0-11
29182412-11	2018	Vasopressin-regulated changes in aquaporin channels may potentially partially explain the mechanism of increased body water loss with water loading.	Water	134-139	arginine vasopressin	Homo sapiens	0-11
30229491-7	2018	In terms of chemical characteristics of PM2.5, the most abundant water-soluble ions of PM2.5 were secondary inorganic aerosols (SO42-, NO3-, and NH4+) which accounted for 55-81% of water-soluble ions and 29-52% of marine PM2.5.	Water	65-70	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
30103278-10	2018	A clinically positive ice water test (maximum detrusor pressure &gt;15 cmH2 O) was identified in 75 patients (37.3%).	Water	26-31	troponin T2, cardiac type	Homo sapiens	71-75
29945017-6	2018	The introduction of mono-unsaturation in the form of a C18:1 chain reduced the Krafft point and gave a surfactant that produced worm-like micelles in water without additives at room temperature.	Water	150-155	Bardet-Biedl syndrome 9	Homo sapiens	55-58
29904932-6	2018	For example, stem xylem vulnerability to cavitation (P50 ) was correlated with the water potential at stomatal closure (Pclose ); more resistant species had a more negative water potential at stomatal closure.	Water	83-88	nuclear factor kappa B subunit 1	Homo sapiens	53-56
30242837-10	2018	We found that (1) plasma hyperosmolality suppressed both components in hyperthermia, (2) the suppression was released by drinking 200 mL of water simultaneously with enhanced cutaneous vasodilatation and sweating responses, and (3) a rapid infusion at 1.0 and 0.2 ml min-1  kg-1 for the first 10 min and the following 20 min, respectively, increased the synchronized component and cutaneous vasodilatation in diuretic-induced hypovolaemia greater than those in a time control; at 0.1 ml min-1  kg-1 for 30 min no greater increases in the non-synchronized component and sweating responses were observed during rapid infusion than in the time control.	Water	140-145	CD59 molecule (CD59 blood group)	Homo sapiens	267-278
30242837-10	2018	We found that (1) plasma hyperosmolality suppressed both components in hyperthermia, (2) the suppression was released by drinking 200 mL of water simultaneously with enhanced cutaneous vasodilatation and sweating responses, and (3) a rapid infusion at 1.0 and 0.2 ml min-1  kg-1 for the first 10 min and the following 20 min, respectively, increased the synchronized component and cutaneous vasodilatation in diuretic-induced hypovolaemia greater than those in a time control; at 0.1 ml min-1  kg-1 for 30 min no greater increases in the non-synchronized component and sweating responses were observed during rapid infusion than in the time control.	Water	140-145	CD59 molecule (CD59 blood group)	Homo sapiens	487-498
30184769-2	2018	This method makes it possible to synthesize a nanosized single-phase product by activating reaction mixtures containing CaHPO4, CaO, La(OH)3 and SiO2 H2O for 25-30 min in AGO-2 and AGO-3 planetary mills.	Water	150-153	argonaute RISC catalytic component 2	Homo sapiens	171-176
30080586-0	2018	Ultrasonic modification of carbonate scale electrochemically deposited in tap water.	Water	78-83	SEC14 like lipid binding 2	Homo sapiens	74-77
30011011-0	2018	Water Contaminants Associated With Unconventional Oil and Gas Extraction Cause Immunotoxicity to Amphibian Tadpoles.	Water	0-5	gastrin	Mus musculus	58-61
30011011-1	2018	Chemicals associated with unconventional oil and gas (UOG) operations have been shown to contaminate surface and ground water with a variety of endocrine disrupting compounds (EDCs) inducing multiple developmental alteration in mice.	Water	120-125	gastrin	Mus musculus	49-52
30387422-19	2018	CONCLUSION: In our study, the hypertension-associated polymorphisms are linked to the renin-angiotensin-aldosterone axis (ACE I/D, ACE A2350G), as well as to salt and water management (ADD1 G460W, GNB3 C825T).	Water	167-172	renin	Homo sapiens	86-91
30381276-0	2018	TRPA1 and substance P mediate stress induced duodenal lesions in water immersion restraint stress rat model.	Water	65-70	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	0-5
30099301-9	2018	While both system-level models have some discrepancies with the measurements, the two-rate model based on the nitrate ion concentration is concluded to be more useful for determining the NO3- formation rates in the context of irrigation water enrichment.	Water	237-242	NBL1, DAN family BMP antagonist	Homo sapiens	187-190
30165322-7	2018	Full-scale testing in a biologically activated membrane bioreactor (BAMBi) system treating 75 L/day of nutrient-supplemented hand washing water showed that long-term operation (100 days) can deliver effective carbon removal (95%) without detrimental fouling or other disruptions caused by cell growth.	Water	138-143	BMP and activin membrane bound inhibitor	Homo sapiens	68-73
30387422-19	2018	CONCLUSION: In our study, the hypertension-associated polymorphisms are linked to the renin-angiotensin-aldosterone axis (ACE I/D, ACE A2350G), as well as to salt and water management (ADD1 G460W, GNB3 C825T).	Water	167-172	angiotensin I converting enzyme	Homo sapiens	122-125
30295298-5	2018	No polymeric structures were obtained in the CoII and NiII complexes due to the higher affinity of these metals for water than that for the m-carboranylphosphinate and accordingly, these complexes generate supramolecular hydrophobic/hydrophilic structures.	Water	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
30281975-1	2018	The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel, crucial to epithelial salt and water homeostasis, and defective due to mutations in its gene in patients with cystic fibrosis, is a unique member of the large family of ATP-binding cassette transport proteins.	Water	109-114	CF transmembrane conductance regulator	Homo sapiens	4-55
30281975-1	2018	The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel, crucial to epithelial salt and water homeostasis, and defective due to mutations in its gene in patients with cystic fibrosis, is a unique member of the large family of ATP-binding cassette transport proteins.	Water	109-114	CF transmembrane conductance regulator	Homo sapiens	57-61
30384747-1	2018	Using molecular dynamics simulations, we assess the uniaxial deformation response of ice I h as described by two popular water models, namely, the all-atom TIP4P/Ice potential and the coarse-grained mW model.	Water	121-126	carboxylesterase 2	Homo sapiens	85-88
30367509-11	2018	Hydrogen water can reduce tendon adhesion after tendon repairing and prohibit excessive inflammatory response, which could be associated with the activation of the Nrf2 pathway.	Water	9-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	164-168
30774873-4	2019	We also show that Cr[Bi(SCN)6] can reversibly uptake water into its framework structure pointing towards the possibility of using these frameworks for host/guest chemistry.	Water	53-58	jagunal homolog 1	Homo sapiens	24-29
29860008-9	2018	Realistic application of the composite for the removal of dye from raw water samples revealed the applicability of the product for the purification of tap water, groundwater, and sewage water.	Water	71-76	SEC14 like lipid binding 2	Homo sapiens	151-154
30505884-4	2018	In this model, animals are given two bottles, one with a diluted solution of ethanol in water, and the other with tap water.	Water	118-123	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	114-117
30347770-3	2018	In this research, a series of prostate-specific membrane antigen (PSMA)-activated CPT prodrugs were designed and synthesized by coupling water-soluble pentapeptide, a PSMA hydrolyzing substrate, to CPT through an appropriate linker.	Water	137-142	folate hydrolase 1	Homo sapiens	30-64
30347770-3	2018	In this research, a series of prostate-specific membrane antigen (PSMA)-activated CPT prodrugs were designed and synthesized by coupling water-soluble pentapeptide, a PSMA hydrolyzing substrate, to CPT through an appropriate linker.	Water	137-142	folate hydrolase 1	Homo sapiens	66-70
30347770-3	2018	In this research, a series of prostate-specific membrane antigen (PSMA)-activated CPT prodrugs were designed and synthesized by coupling water-soluble pentapeptide, a PSMA hydrolyzing substrate, to CPT through an appropriate linker.	Water	137-142	folate hydrolase 1	Homo sapiens	167-171
30347770-6	2018	Most of the newly synthesized CPT prodrugs showed excellent selective toxicity to PSMA-producing prostate cancer cells LNCaP-FGC with improved water solubility.	Water	143-148	folate hydrolase 1	Homo sapiens	82-86
30264061-1	2018	Water-soluble and fluorescent perylene dyes PMI1 and PMI2 with red to near-infrared (red-NIR) emission and a large Stokes shift were designed and synthesized.	Water	0-5	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	89-92
30338341-4	2018	This is much lower than required by the People"s Republic of China Surface Water Environmental Quality Standard (2.2 muM).	Water	75-80	latexin	Homo sapiens	117-120
30216076-4	2018	The water-induced surface restructuring of the polyrotaxane films slightly affects the adsorption structure of the fibrinogen molecules.	Water	4-9	fibrinogen beta chain	Homo sapiens	115-125
30280885-4	2018	Water samples with high total dissolved solids (conductivity &gt;100 mS cm-1) were also successfully analyzed after a simple dilution, yet the associated detection limit was higher (17 pg L-1, 0.61 Bq L-1, 16 pCi L-1).	Water	0-5	L1 cell adhesion molecule	Homo sapiens	188-191
30280885-4	2018	Water samples with high total dissolved solids (conductivity &gt;100 mS cm-1) were also successfully analyzed after a simple dilution, yet the associated detection limit was higher (17 pg L-1, 0.61 Bq L-1, 16 pCi L-1).	Water	0-5	L1 cell adhesion molecule	Homo sapiens	201-204
30280885-4	2018	Water samples with high total dissolved solids (conductivity &gt;100 mS cm-1) were also successfully analyzed after a simple dilution, yet the associated detection limit was higher (17 pg L-1, 0.61 Bq L-1, 16 pCi L-1).	Water	0-5	L1 cell adhesion molecule	Homo sapiens	201-204
30025352-3	2018	In this work, we examined the oxidation of As(III) in the presence of Fe(II) in air-saturated water, which is affected by pH, co-existing phosphate, and scavengers (tert-butanol, superoxide dismutase, catalase and dimethylsulfoxide).	Water	94-99	catalase	Homo sapiens	201-209
30119972-12	2018	Under optimum extraction conditions, the method shows low limits of detection in the ranges of 5-10, 8-15 and 32-60 ng L-1 in deionized water, urine, and plasma, respectively.	Water	136-141	immunoglobulin kappa variable 1-16	Homo sapiens	119-122
30066492-10	2018	Particularly, we found a low energy consumption (1.63 Wh L-1 ) for seawater desalination and a high water production rate (25 L m-2  h-1 ) for brackish water.	Water	70-75	L1 cell adhesion molecule	Homo sapiens	57-60
30211531-2	2018	Herein, we report a multifunctional antimicrobial agent (porphyrin-POSS-OPVE, PPO), which combines bacterial membrane intercalation, high density of local QA groups, efficient energy transfer, significantly reduced aggregation, and high water solubility into one single molecule.	Water	237-242	protoporphyrinogen oxidase	Homo sapiens	78-81
30260360-0	2018	Molecular dynamics study on the role of solvation water in the adsorption of hyperactive AFP to the ice surface.	Water	50-55	alpha fetoprotein	Homo sapiens	89-92
30229602-6	2018	NO3--N concentrations were high in midstream soil water.	Water	50-55	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
30226522-2	2018	Herein, two hydroxy-rich hydrazone-based COFs are synthesized in pure water and postsynthetically incorporated with CoII, exhibiting Lewis acid catalytic activity towards cyanosilylation of various aldehydes with size selectivity.	Water	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120
30025226-6	2018	Mixing of drinking water treatment plant finished waters with desalinated water decreased the overall DBP formation potential of the water but resulted in the increased formation of brominated DBPs after long chlorine contact time.	Water	19-24	D-box binding PAR bZIP transcription factor	Homo sapiens	102-105
30098730-1	2018	This paper describes the development of a novel gas chromatography-mass spectrometry-selected ion monitoring (GC/MS-SIM) method for the determination of trace water contents of organic solvents, using the characteristic m/z 18, m/z 17, and m/z 16 ions of H2O as the qualitative ion and the m/z 18 ion as the quantifier ion.	Water	159-164	small nucleolar RNA, C/D box 102	Homo sapiens	222-226
30098730-1	2018	This paper describes the development of a novel gas chromatography-mass spectrometry-selected ion monitoring (GC/MS-SIM) method for the determination of trace water contents of organic solvents, using the characteristic m/z 18, m/z 17, and m/z 16 ions of H2O as the qualitative ion and the m/z 18 ion as the quantifier ion.	Water	159-164	small nucleolar RNA, C/D box 102	Homo sapiens	292-296
30025226-6	2018	Mixing of drinking water treatment plant finished waters with desalinated water decreased the overall DBP formation potential of the water but resulted in the increased formation of brominated DBPs after long chlorine contact time.	Water	50-55	D-box binding PAR bZIP transcription factor	Homo sapiens	102-105
30025226-6	2018	Mixing of drinking water treatment plant finished waters with desalinated water decreased the overall DBP formation potential of the water but resulted in the increased formation of brominated DBPs after long chlorine contact time.	Water	50-55	D-box binding PAR bZIP transcription factor	Homo sapiens	102-105
30286083-10	2018	Transcriptome profiling in the anther tissues further exhibited ICE1-modulated genes associated with water transport and ion exchange in the anther.	Water	101-106	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	64-68
30289953-6	2018	In addition, monitoring by a quartz crystal microbalance with admittance analysis showed that the denaturing of immobilized SOD1 on a sensor under the hydrogelation conditions at pH 3.0 and 4.0 resulted in an increase in the effective acoustic thickness from ~3.3 nm (a folded rigid form) to ~50 and ~100 nm (an extended water-rich state), respectively.	Water	321-326	superoxide dismutase 1	Homo sapiens	124-128
30289953-7	2018	In contrast, when SOD1 was denatured under the same conditions at pH 5.0, a compact water-poor state with an effective acoustic thickness of ~10 nm was formed.	Water	84-89	superoxide dismutase 1	Homo sapiens	18-22
30289953-8	2018	The addition of physiological concentrations of NaCl to the pH 4.0 sample induced a further extension of the SOD1 with larger amounts of water molecules (with an effective acoustic thickness of ~200 nm) but suppressed hydrogel formation.	Water	137-142	superoxide dismutase 1	Homo sapiens	109-113
30168716-3	2018	Our studies not only prove the feasibility of this concept but also disclose a novel 2-fold C-H/C-H cross-coupling reaction of N-(hetero)arylimidazolium salts with various (hetero)arenes to access water-soluble, fluorescent, cationic, and planar polycyclic heteroaromatic molecules, in which RhCl3 3H2O outperforms [Cp*RhCl2]2.	Water	197-202	churchill domain containing 1	Homo sapiens	92-99
29886332-0	2018	Degradation mechanism of cyanide in water using a UV-LED/H2O2/Cu2+ system.	Water	36-41	small integral membrane protein 10 like 2A	Homo sapiens	53-56
29929105-2	2018	For eutrophic water, the macrophyte configuration increased the average removal efficiency (RE) from 41.6% to 68.6% and from 70.2% to 83.7% for NO3--N and TN in the final BCW effluent, respectively, with the concentrations decreasing from 3.08 mg/L to 1.04 mg/L and from 4.94 mg/L to 3.12 mg/L, respectively.	Water	14-19	NBL1, DAN family BMP antagonist	Homo sapiens	144-147
30081305-4	2018	Moreover, the as-prepared SPN1 possess good water-dispersibility, robust size-stability and excellent photothermal properties.	Water	44-49	sarcospan	Homo sapiens	26-30
30081305-6	2018	Finally, the as-prepared water-dispersible SPN1 displays good biocompatibility and biosafety, making it a promising candidate for future biomedical applications.	Water	25-30	sarcospan	Homo sapiens	43-47
30145050-7	2018	WaterMap analysis of the crystal structures suggests that unfavorable water molecules are the likely reason for the difference in orientation of the 1H-pyrrolo[2,3-b]pyridine-5-carboxamide scaffold to the hinge region among JAKs.	Water	70-75	Janus kinase 1	Homo sapiens	224-228
29890489-7	2018	Finally, it was demonstrated that the data from intensive monitoring of free chlorine residual and water temperature as DBP proxy parameters, when processed using cluster analysis, could also help identify the optimal sampling points and periods for regulatory THMs and HAAs monitoring.	Water	99-104	D-box binding PAR bZIP transcription factor	Homo sapiens	120-123
29758100-1	2018	Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining water and electrolytes homoeostasis, and its deregulation contributes to the development of arterial hypertension.	Water	80-85	renin	Homo sapiens	0-5
29574657-6	2018	It was found that, in shallow groundwater, the concentrations of 11 components (NO3-, NH4+, Fe, Mn, As, Al, rare NO2-, Se, Hg, Tl and Pb) exceed the limits referenced in the standards for drinking water.	Water	36-41	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
30301075-7	2018	These findings suggest that previous oil spill simulations may have overestimated the number of small droplets (&lt;=70 mum) at the water-ice interface.	Water	132-137	latexin	Homo sapiens	120-123
29960262-7	2018	We observed that water-soluble inorganic ions, especially nitrate (NO3-) and ammonium, had stronger influences on 3 hormones.	Water	17-22	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
29960262-12	2018	Our findings suggested that water-soluble inorganic constituents of PM2.5 (especially, NO3-) might have stronger influences on the activation of HPA axis than carbonaceous and elemental components.	Water	28-33	NBL1, DAN family BMP antagonist	Homo sapiens	87-90
30055315-3	2018	Herein, we characterized the phenolic composition, the antioxidant activity, and inhibition of angiotensin-converting enzyme (ACE) of three different extracts (water, propanone, and ethanol) from this residue and assessed the structure-activity using bivariate and multivariate statistical approaches.	Water	160-165	angiotensin I converting enzyme	Rattus norvegicus	126-129
30226923-3	2018	Here, using classical molecular dynamics simulations, we have systematically investigated the effect that three different water models (SPC/E, TIP4P/2005 and TIP5P) have on the structure of water confined between two rigid graphene sheets with a 0.9 nm separation.	Water	190-195	proline rich protein gene cluster	Homo sapiens	136-139
30355103-12	2018	In addition, the neurological deficit scores, brain water content, and inflammatory response were all also reduced in the IL-1R1-deficient mice.	Water	52-57	interleukin 1 receptor, type I	Mus musculus	122-128
30170291-2	2018	Here, we firstly synthesized the two TpT dimeric lesions with satisfactory yields using a unique UV-irradiated water droplet approach followed by HPLC purification.	Water	111-116	limb development membrane protein 1	Homo sapiens	37-40
30275489-7	2018	Pb (250 ppm) was given daily via drinking water.	Water	42-47	serine peptidase inhibitor, Kunitz type, 2	Rattus norvegicus	0-2
30455014-9	2018	In addition, the increased air-flow rates greatly accelerated water removal with high bio-energy efficiencies, especially at 0.8 L min-1 kg-1.	Water	62-67	CD59 molecule (CD59 blood group)	Homo sapiens	131-141
29969132-5	2018	Simulations of water behaviour have been used to probe hydrophobic gates in two recently reported ion channel structures: BEST1 and TMEM175.	Water	15-20	bestrophin 1	Homo sapiens	122-127
29969132-7	2018	In silico mutations of BEST1 have also been used to explore the effect of changes in the hydrophobicity of the gating constriction, demonstrating that substitution of hydrophobic sidechains with more polar sidechains results in an open gate which allows water permeation.	Water	254-259	bestrophin 1	Homo sapiens	23-28
29987303-0	2018	Impact of PEG additives and pore rim functionalization on water transport through sub-1 nm carbon nanotube porins.	Water	58-63	SUB1 regulator of transcription	Homo sapiens	82-87
29987303-2	2018	In the past, sub-1 nm diameter carbon nanotube porins (CNTPs) embedded in a lipid membrane matrix demonstrated extremely high water permeabilities and strong ion selectivities.	Water	126-131	SUB1 regulator of transcription	Homo sapiens	13-18
30157375-6	2018	Diffraction data was collected from aligned fibrils formed by Ac-beta3[LIA] in water and used to inform and validate the model structure.	Water	79-84	small nucleolar RNA, H/ACA box 3A	Homo sapiens	62-70
30157632-5	2018	Our results show that the native enzyme limits the access of water molecules to the active site, enhancing the interaction between the reactants and providing a more favorable electrostatic environment to assist the SN2 methyl transfer reaction.	Water	61-66	solute carrier family 38 member 5	Homo sapiens	216-219
30479921-4	2018	This PNAGA-PCBAA hydrogel physically crosslinked by dual amide hydrogen bonds of NAGA exhibits an ultralow solid content (1.6, 98.4 wt% water content), and shear-thinning behavior, body temperature extrudability/self-healability, rapid network recoverability, and very close key parameters (modulus, antifouling/antifibrosis, light transmittance, refractive index, ultrastability) to human vitreous body.	Water	136-141	alpha-N-acetylgalactosaminidase	Homo sapiens	6-10
30009517-5	2018	In the resting state, the catalyst returns to the original six-coordinate high-spin CoII state with a pentapyridyl and one water molecule coordinating to the metal center.	Water	123-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-88
29959186-6	2018	The results showed that EPO could promote interleukin (IL) 10 (IL-10) expression; inhibit tumor necrosis factor-alpha (TNF-alpha), IL-6, and inducible nitric oxide synthase (iNOS) expressions; reduce the fractional excretion of sodium (FENa) and plasma creatinine (CREA) and urea; and promote the recovery of water and salt handling and AQP2 expression in BUO-R rats, especially in the high dose of EPO-treated group rats.	Water	309-314	nitric oxide synthase 2	Rattus norvegicus	174-178
30151540-4	2018	The standard addition experimental results of two real water samples with an addition level of 10 and 50 mug L-1 showed that the recoveries were between 92.4% and 108.9% with RSDs from 2.01% to 3.22%.	Water	55-60	L1 cell adhesion molecule	Homo sapiens	109-112
30044903-4	2018	Optical transmittance and TEM measurements provide strong evidence that receptor 1 undergoes co-assemble with amphiphilic guest C10 in water to form supramolecular bilayer vesicles (diameter 25.6+-2.7 nm, wall thickness  3.5 nm) that can encapsulate the hydrophilic anticancer drug doxorubicin (DOX) and the hydrophobic dye Nile red (NR).	Water	135-140	homeobox C10	Homo sapiens	128-131
30244370-6	2018	Similarly, the vertical and horizontal distribution patterns of Cl, SO4, HCO3, NO3, and PO4 in Mujib reservoir water showed insignificant variations in surface water layer and relatively unchanged values or decreasing trends through the water column.	Water	111-116	NBL1, DAN family BMP antagonist	Homo sapiens	79-82
29920829-1	2018	Water-soluble Pd12 L6 coordination cage TC-1 was synthesized by coordination-driven self-assembly of symmetrical tetrapyridyl donor L with 90  ditopic acceptor cis-[Pd(NO3 )2 (tmeda)] [tmeda=N,N,N",N"-tetramethylethane-1,2-diamine].	Water	0-5	NBL1, DAN family BMP antagonist	Homo sapiens	168-171
30188715-2	2018	Here we show that water dynamics and interactions can be controlled by the protonation state of ligand using continuous constant pH molecular dynamics simulations of two closely related model systems, beta-secretase 1 and 2 (BACE1 and BACE2), in complex with a small-molecule inhibitor.	Water	18-23	beta-secretase 1	Homo sapiens	201-223
30188715-2	2018	Here we show that water dynamics and interactions can be controlled by the protonation state of ligand using continuous constant pH molecular dynamics simulations of two closely related model systems, beta-secretase 1 and 2 (BACE1 and BACE2), in complex with a small-molecule inhibitor.	Water	18-23	beta-secretase 1	Homo sapiens	225-230
30183242-7	2018	The Janus foam can therefore be used for harvesting water in fog environments, and the maximum water-collecting efficiency is 3.7 g cm-2 h-1, which is much better than existing data.	Water	52-57	zinc finger protein, FOG family member 1	Homo sapiens	61-64
30208517-6	2018	Hence, ERK1/2 expression was also detected under 200 cm H2O hydrostatic pressure.	Water	56-59	mitogen-activated protein kinase 3	Homo sapiens	7-13
30208517-7	2018	Western blot showed that 200 cm H2O pressure promoted the expression of ERK1/2.	Water	32-35	mitogen-activated protein kinase 3	Homo sapiens	72-78
30190124-6	2018	Moreover, miR-590-5p overexpression remarkably increased the cerebral water content and neurological severity scores compared with that of scramble group in ICH mice.	Water	70-75	microRNA 590	Mus musculus	10-17
29891307-1	2018	A novel water-soluble polysaccharide (named ALP-1) was successfully isolated from the stem barks of Acanthopanax leucorrhizus by hot-water extraction, and further purified by Cellulose DEAE-52 and Sephadex G-100 chromatography.	Water	8-13	asparaginase and isoaspartyl peptidase 1	Homo sapiens	44-49
29891307-1	2018	A novel water-soluble polysaccharide (named ALP-1) was successfully isolated from the stem barks of Acanthopanax leucorrhizus by hot-water extraction, and further purified by Cellulose DEAE-52 and Sephadex G-100 chromatography.	Water	133-138	asparaginase and isoaspartyl peptidase 1	Homo sapiens	44-49
30294630-1	2018	The presence of elevated nitrate (NO3-) and nitrite (NO2-) concentration in drinking water higher than the standard limits could endanger the health of consumers.	Water	85-90	NBL1, DAN family BMP antagonist	Homo sapiens	34-37
30294630-8	2018	Although, the average concentration of NO3- and NO2- in drinking water was lower than the national standard limits, but the non-carcinogenic risk assessment showed that the children and adults are at a significant risk via nitrate and nitrite in the rural Divandarreh County (TTHQ &gt; 1).	Water	65-70	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
30195309-1	2018	Monte Carlo (MC) simulations of the SPC/E liquid water model are performed at two numbers of molecules N = 100 and 512 and in canonical NVT, isobaric NPT, and grand canonical muVT ensembles.	Water	49-54	proline rich protein gene cluster	Homo sapiens	36-39
29913613-0	2018	Influence of recent climatic events on the surface water storage of the Tonle Sap Lake.	Water	51-56	SH2 domain containing 1A	Homo sapiens	78-81
30217234-7	2018	RESULTS: Ion channels exhibited cut-off effects associated with hydrocarbon molar water solubility in the following order of decreasing solubility: Nav1.2   Nav1.4   TRESK   TREK-1 &gt; GABAA &gt;&gt; glycine.	Water	82-87	potassium two pore domain channel subfamily K member 18	Homo sapiens	166-171
30217234-7	2018	RESULTS: Ion channels exhibited cut-off effects associated with hydrocarbon molar water solubility in the following order of decreasing solubility: Nav1.2   Nav1.4   TRESK   TREK-1 &gt; GABAA &gt;&gt; glycine.	Water	82-87	potassium two pore domain channel subfamily K member 2	Homo sapiens	174-180
30106269-9	2018	The dual biosensors were successfully applied for the determination of H2O2 in rainwater, tap water, and waste water samples.	Water	94-99	SEC14 like lipid binding 2	Homo sapiens	90-93
30152699-0	2018	Co(II)/Ag(I) Synergistically Catalyzed Monoinsertion Reaction of Isocyanide to Terminal Alkynes with H2O: Synthesis of Alkynamide Derivatives.	Water	101-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
30152699-1	2018	A Co(II)/Ag(I) synergistically catalyzed three-component reaction of isocyanide with terminal alkyne and water to afford alkynamide derivatives is reported.	Water	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
30208517-9	2018	CONCLUSIONS: Cyclic hydrostatic pressure increases the expression of uroplakins via activating ERK1/2 signaling pathway in human UCs, and 200 cm H2O pressure may be an optimal stress parameter to promote the uroplakin expression.	Water	145-148	mitogen-activated protein kinase 3	Homo sapiens	95-101
30070288-1	2018	It is known that both cis,fac-[RuCl2(DMSO)3(H2O)] (1a) and trans,cis,cis-[RuCl2(DMSO)2(H2O)2] (2a) complexes, which are formed on the dissolution of trans and cis-isomers of [RuCl2(DMSO)4] in water, demonstrate light-induced anticancer activity.	Water	44-47	FA complementation group C	Homo sapiens	26-29
30188042-5	2018	NO3-, SO42-, and NH4+(SNA)were the main water-soluble ions.	Water	40-45	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
30188054-4	2018	Na+, Ca2+, Mg2+, and SO42- were the major ions present in water, with mean concentrations of 202.8, 86.0, 78.6, and 431.2 mg L-1 respectively.	Water	58-63	L1 cell adhesion molecule	Homo sapiens	125-128
30188055-4	2018	The characteristics and influencing factors of NO3 type water in shallow groundwater are analyzed, and the significance of NO3 type water is discussed.	Water	56-61	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
30188055-4	2018	The characteristics and influencing factors of NO3 type water in shallow groundwater are analyzed, and the significance of NO3 type water is discussed.	Water	79-84	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
30188055-6	2018	NO3 type water comprises 20.9% of all effective data for the area and is mainly distributed in the southeast and a few parts of the northern mountainous area.	Water	9-14	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
30188055-7	2018	Based on the characteristics of NO3 type water, this can be classified as high TDS NO3 type water or low TDS NO3 type water.	Water	41-46	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
30188055-7	2018	Based on the characteristics of NO3 type water, this can be classified as high TDS NO3 type water or low TDS NO3 type water.	Water	41-46	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
30188055-7	2018	Based on the characteristics of NO3 type water, this can be classified as high TDS NO3 type water or low TDS NO3 type water.	Water	41-46	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
30188055-7	2018	Based on the characteristics of NO3 type water, this can be classified as high TDS NO3 type water or low TDS NO3 type water.	Water	92-97	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
30188055-7	2018	Based on the characteristics of NO3 type water, this can be classified as high TDS NO3 type water or low TDS NO3 type water.	Water	92-97	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
30188055-10	2018	The formation of NO3 type water is mainly driven by human domestic sewage, agricultural fertilization, and septic tank and landfill leachate infiltration, among others.	Water	26-31	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
30188055-11	2018	The pollution load of high TDS NO3 type water is generally higher than that of low TDS NO3 type water.	Water	40-45	NBL1, DAN family BMP antagonist	Homo sapiens	31-34
30188055-12	2018	Analysis of NO3 type water makes it possible to prevent and control groundwater pollution when there is an increasing pollution trend but pollution is not yet severe.	Water	21-26	NBL1, DAN family BMP antagonist	Homo sapiens	12-15
30113168-5	2018	In particular, the two-step SCO properties in 1 EtOH,H2O are deactivated such that both the partially solvated (1 H2O) and desolvated (1 O) phases show abrupt and hysteretic one-step SCO behaviors with differing transition temperatures (1 H2O: T1/2 : 215 T1/2 : 235 K; 1 O: T1/2 : 170 T1/2 : 182 K).	Water	53-56	CD6 molecule	Homo sapiens	244-289
30137083-1	2018	Surface-confined host-guest chemistry at the air/solid interface is used for trapping a functionalized 3D Zn-phthalocyanine complex into a 2D porous supramolecular template allowing the large area functionalization of an sp2-hybridized carbon-based substrate as evidenced by STM, resonance Raman spectroscopy, and water contact angle measurements.	Water	314-319	Sp2 transcription factor	Homo sapiens	221-224
29913372-8	2018	Results indicated their additional generation in the surface water, since BPA-MME and BPA-DME in the surface river water were with similar level or even higher than effluent in WWTPs.	Water	61-66	membrane metalloendopeptidase	Homo sapiens	78-81
31459186-5	2018	Additionally, the block elastomer was employed to further estimate its reinforcing effect in SPI resin modification, which also exhibited favorable water resistance and adhesion performance.	Water	148-153	chromogranin A	Homo sapiens	93-96
30113168-5	2018	In particular, the two-step SCO properties in 1 EtOH,H2O are deactivated such that both the partially solvated (1 H2O) and desolvated (1 O) phases show abrupt and hysteretic one-step SCO behaviors with differing transition temperatures (1 H2O: T1/2 : 215 T1/2 : 235 K; 1 O: T1/2 : 170 T1/2 : 182 K).	Water	114-117	CD6 molecule	Homo sapiens	244-289
30113168-5	2018	In particular, the two-step SCO properties in 1 EtOH,H2O are deactivated such that both the partially solvated (1 H2O) and desolvated (1 O) phases show abrupt and hysteretic one-step SCO behaviors with differing transition temperatures (1 H2O: T1/2 : 215 T1/2 : 235 K; 1 O: T1/2 : 170 T1/2 : 182 K).	Water	114-117	CD6 molecule	Homo sapiens	244-289
30254507-8	2018	The present study provides evidence that DNA methylation of Tbx21 and Rorc may be associated with the development of EAU.	Water	117-120	RAR-related orphan receptor gamma	Mus musculus	70-74
29767557-8	2018	Conversely, mRNA expression levels in kidney of genes encoding solute and water transporters in the proximal tubule ( Abcg2 and Slc34a1) and collecting duct ( Aqp2, Scnn1a, and Scnn1b) remained comparable between control and iKsp- Pkd1-/- mice, although a water reabsorption defect was observed in iKsp- Pkd1-/- mice.	Water	74-79	sodium channel, nonvoltage-gated 1 beta	Mus musculus	177-183
29946843-1	2018	Consumption of high NO3 containing water may pose serious health hazard especially in children (&lt; 5 years).	Water	35-40	NBL1, DAN family BMP antagonist	Homo sapiens	20-23
29890403-0	2018	Correlating interfacial water dynamics with protein-protein interaction in complex of GDF-5 and BMPRI receptors.	Water	24-29	growth differentiation factor 5	Homo sapiens	86-91
29890403-7	2018	Here we report the effect of pH on dynamics of water present at the interface of GDF-5:BMPRIA and GDF-5:BMPRIB and binding interaction energy of these complexes.	Water	47-52	growth differentiation factor 5	Homo sapiens	81-86
29890403-7	2018	Here we report the effect of pH on dynamics of water present at the interface of GDF-5:BMPRIA and GDF-5:BMPRIB and binding interaction energy of these complexes.	Water	47-52	growth differentiation factor 5	Homo sapiens	98-103
30121213-0	2018	Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies.	Water	28-33	prostaglandin D2 synthase	Homo sapiens	91-115
30121213-7	2018	Our quantitative studies including crystal water molecules explained that compounds with an elongated backbone structure to fit from the deep inner cavity to the peripheral part of the cavity would have strong affinity to human H-PGDS.	Water	43-48	hematopoietic prostaglandin D synthase	Homo sapiens	228-234
29775944-5	2018	The PCB levels in water (14.7 ng L-1) were 14 times higher than the limits permitted by the Brazilian legislation in the Salto Santiago (SS) reservoir.	Water	18-23	pyruvate carboxylase	Homo sapiens	4-7
29790390-2	2018	We previously demonstrated that the collecting duct PRR regulates epithelial Na+ channel (ENaC) activity and water transport; however, which cell type is involved remains unclear.	Water	109-114	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	52-55
29790390-9	2018	Taken together, these findings indicate that PC, but not IC, PRR modulates ENaC activity, urinary Na+ excretion, and water transport.	Water	117-122	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	61-64
30324163-1	2018	Aquaporin (AQP) 3, a facilitated transporter of water and glycerol, expresses in placenta and fetal membranes, but the detailed localization and function of AQP3 in placenta remain unclear.	Water	48-53	aquaporin 3	Mus musculus	0-17
30324163-10	2018	These results suggest a role for AQP3 in supplying nutrients from yolk sac and maternal blood to developing fetus by facilitating transport of glycerol in addition to water, and its implication for the fetal growth in utero.	Water	167-172	aquaporin 3	Mus musculus	33-37
29934829-6	2018	Dissolution of calcite from limestone bedrock and a high concentration of bicarbonate ions in natural river water (about 250 mg L-1) enhanced the neutralization of acidic river water and subsequent chemical precipitation of metals and arsenic.	Water	108-113	immunoglobulin kappa variable 1-16	Homo sapiens	128-131
29594432-1	2018	Congenital nephrogenic diabetes insipidus (CNDI) is characterized by the reduced ability of renal collecting duct cells to reabsorb water in response to the antidiuretic effect of vasopressin.	Water	132-137	arginine vasopressin	Homo sapiens	180-191
29934829-6	2018	Dissolution of calcite from limestone bedrock and a high concentration of bicarbonate ions in natural river water (about 250 mg L-1) enhanced the neutralization of acidic river water and subsequent chemical precipitation of metals and arsenic.	Water	177-182	immunoglobulin kappa variable 1-16	Homo sapiens	128-131
30022393-2	2018	Our aim was to identify the processes which control the spatial and temporal distribution of NO3- in the shallow groundwater and assess water-rock interactions linked to denitrification.	Water	119-124	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
30027376-1	2018	Fe-based metal-organic framework MIL-88A microrods were synthesized by hydrothermal method, which were used to adsorb As(V) in water for the first time.	Water	127-132	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	118-123
29705527-4	2018	From this data collection obtained over recent years of monitoring the CEA Valduc facilities and environment, a direct relation was highlighted between the 3H-samplers trapping efficiency of tritium as tritiated water and the sampling time and conditions of use: temperature and atmospheric moisture.	Water	212-217	CEA cell adhesion molecule 3	Homo sapiens	71-74
29241298-7	2018	The SP2 and SP3 springs can derive from the mixing of the saline water (SP1 ) and fresh water (SP4 ).	Water	65-70	Sp2 transcription factor	Homo sapiens	4-7
29241298-7	2018	The SP2 and SP3 springs can derive from the mixing of the saline water (SP1 ) and fresh water (SP4 ).	Water	65-70	Sp3 transcription factor	Homo sapiens	12-15
29241298-7	2018	The SP2 and SP3 springs can derive from the mixing of the saline water (SP1 ) and fresh water (SP4 ).	Water	88-93	Sp2 transcription factor	Homo sapiens	4-7
29241298-7	2018	The SP2 and SP3 springs can derive from the mixing of the saline water (SP1 ) and fresh water (SP4 ).	Water	88-93	Sp3 transcription factor	Homo sapiens	12-15
29544141-8	2018	Tap water radon levels inside the spa present an average value of 50 +- 8 kBq m-3, which does not exceed the level stipulated by the Spanish Nuclear Safety Council (CSN) of 100 kBq m-3 for water used for human consumption.	Water	4-9	SEC14 like lipid binding 2	Homo sapiens	0-3
29680043-5	2018	The mixture of 75:25(v/v) EtOH:H2O showed the highest values with 254 mgGAE/gDE and 146 mgCATE/gDE respectively.	Water	31-34	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	76-79
29680043-5	2018	The mixture of 75:25(v/v) EtOH:H2O showed the highest values with 254 mgGAE/gDE and 146 mgCATE/gDE respectively.	Water	31-34	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	95-98
29680043-6	2018	HORAC, HOSC and FRAP were used to determine the AA of the extracts being also highest for the mixture of 75:25(v/v) EtOH:H2O (4690 micromolCAE/gDE, 4527 micromolTE/gDE and 2197 micromolTE/gDE, respectively).	Water	121-124	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	143-146
30195679-5	2018	The pH of fog water samples ranged from weakly acidic (pH4.3) to weakly alkaline (pH7.05) and the EC ranged from 32.4 to 436.3muS/cm.	Water	14-19	zinc finger protein, FOG family member 1	Homo sapiens	10-13
30195679-6	2018	The main cations in fog water were NH4+ and Ca2+, accounting for 12.35% and 29.07% of those inorganic ions, respectively.	Water	24-29	zinc finger protein, FOG family member 1	Homo sapiens	20-23
30056028-1	2018	BACKGROUND: Mizagliflozin is a novel oral sodium-glucose cotransporter 1 (SGLT1) inhibitor that increases luminal glucose and water.	Water	126-131	solute carrier family 5 member 1	Homo sapiens	42-72
29664160-2	2018	This may be explained by a stress-mediated activation of the vasopressin system with an increase in free-water reabsorption.	Water	105-110	arginine vasopressin	Homo sapiens	61-72
30206530-5	2018	Results: After thermoforming, the transparency of Duran and Essix A+ decreased, while the water absorption ability of all materials; the water solubility of Duran, Essix A+, and Essix ACE; and the surface hardness of Duran and Essix A+ increased.	Water	137-142	angiotensin I converting enzyme	Homo sapiens	184-187
30032995-13	2018	Moreover, the expression of mCherry in response to the presence of ecdysteroid in water suggests that EcRE-mCh could be used for monitoring ecdysteroid activities in environmental water.	Water	82-87	modifier of chinchilla	Mus musculus	28-31
29883663-9	2018	Here, we describe how to enable the co-delivery of a TLR7 agonist in a squalene-based oil-in-water emulsion, for adjuvant evaluation.	Water	93-98	toll like receptor 7	Homo sapiens	53-57
29429048-0	2018	Peptide YY Causes Apathy-Like Behavior via the Dopamine D2 Receptor in Repeated Water-Immersed Mice.	Water	80-85	peptide YY	Mus musculus	0-10
29429048-0	2018	Peptide YY Causes Apathy-Like Behavior via the Dopamine D2 Receptor in Repeated Water-Immersed Mice.	Water	80-85	dopamine receptor D2	Mus musculus	47-67
29932826-3	2018	We recently reported that the inner medullary collecting duct (IMCD), which functions in the regulation of water-reabsorption, via the actions of vasopressin, expresses many of the enzymes that can modulated K-acetylation.	Water	107-112	arginine vasopressin	Rattus norvegicus	146-157
29932826-8	2018	The acetylated proteins were expressed in all compartments of the cell and were enriched in pathways including glycolysis and vasopressin-regulated water reabsorption.	Water	148-153	arginine vasopressin	Rattus norvegicus	126-137
29932826-9	2018	In the vasopressin-regulated water reabsorption pathway, eight proteins were acetylated, including the novel identification of the basolateral water channel, AQP3, acetylated at K282; 215 proteins were phosphorylated in this IMCD cohort, including AQP2 peptides that were phosphorylated at four serines: 256, 261, 264, and 269.	Water	29-34	arginine vasopressin	Rattus norvegicus	7-18
29932826-9	2018	In the vasopressin-regulated water reabsorption pathway, eight proteins were acetylated, including the novel identification of the basolateral water channel, AQP3, acetylated at K282; 215 proteins were phosphorylated in this IMCD cohort, including AQP2 peptides that were phosphorylated at four serines: 256, 261, 264, and 269.	Water	143-148	arginine vasopressin	Rattus norvegicus	7-18
30056028-1	2018	BACKGROUND: Mizagliflozin is a novel oral sodium-glucose cotransporter 1 (SGLT1) inhibitor that increases luminal glucose and water.	Water	126-131	solute carrier family 5 member 1	Homo sapiens	74-79
29627541-8	2018	Less than 6% of Pb(II) desorbed in water in two consecutive steps than was previously adsorbed, for biochars with a pH below 7, irrespective of oxidation.	Water	35-40	submaxillary gland androgen regulated protein 3B	Homo sapiens	16-22
29673051-1	2018	The ability of leaves to absorb fog water can positively contribute to the water and carbon balance of plants in montane ecosystems, especially in periods of soil water deficit.	Water	36-41	zinc finger protein, FOG family member 1	Homo sapiens	32-35
29732663-8	2018	Based on these findings, we suggest that xylem sap pressurisation and embolism refilling occur gradually over a few weeks through water transfer from parenchyma cells to xylem vessels during daytime, and then the parenchyma are refilled mostly during nighttime by water uptake from soil.	Water	130-135	SH2 domain containing 1A	Homo sapiens	47-50
29732663-8	2018	Based on these findings, we suggest that xylem sap pressurisation and embolism refilling occur gradually over a few weeks through water transfer from parenchyma cells to xylem vessels during daytime, and then the parenchyma are refilled mostly during nighttime by water uptake from soil.	Water	264-269	SH2 domain containing 1A	Homo sapiens	47-50
30052291-5	2018	Here, we report a complete thermodynamic analysis of the reversible, two-state, thermal unfolding of the metastable, 7-kDa N-terminal src-homology 3 domain of the Drosophila signal transduction protein drk in H2 O and D2 O using one-dimensional 19 F NMR spectroscopy.	Water	209-213	downstream of receptor kinase	Drosophila melanogaster	202-205
30221840-2	2018	Enhanced secretion or action of vasopressin could mitigate this through increased free water retention.	Water	87-92	arginine vasopressin	Homo sapiens	32-43
30139551-4	2018	We observed that water loss rate in the cop1-4 and lip1 detached leaves was significantly much faster than wild-type, resulting from failing to reduce the stomatal aperture by the mutants.	Water	17-22	Proteasome component (PCI) domain protein	Arabidopsis thaliana	40-46
29710576-4	2018	With an external resistance of 7.8 Omega and a water (hot side) flow rate of 75 mL min-1, a maximum normalized energy recovery of 4.5 x 10-4 kWh m-3 was achieved under a 2.8  C temperature gradient (DeltaT).	Water	47-52	CD59 molecule (CD59 blood group)	Homo sapiens	83-88
29627541-9	2018	Recovery using an extraction with 0.1M NaNO3 increased from 0.7% to 32.7% of Pb(II) undesorbed by both preceding water extractions with increasing oxidation, for biochars with a pH below 7.	Water	113-118	submaxillary gland androgen regulated protein 3B	Homo sapiens	77-83
30510981-4	2018	Data indicated that average fluoride concentration in drinking water was 0.731 mg L-1.	Water	63-68	immunoglobulin kappa variable 1-16	Homo sapiens	82-85
30091518-5	2018	Biotinylated polymer vesicles that encapsulate catalase, an enzyme which converts hydrogen peroxide to water and oxygen, are prepared and these vesicles are adhered weakly to avidin-coated surfaces.	Water	103-108	catalase	Homo sapiens	47-55
31459117-0	2018	Nitrogen-Doped Nanoporous Carbon Nanospheroids for Selective Dye Adsorption and Pb(II) Ion Removal from Waste Water.	Water	110-115	submaxillary gland androgen regulated protein 3B	Homo sapiens	80-86
30166555-1	2018	The neurohormones arginine-vasopressin (AVP) and oxytocin (OT) synthesised in supraoptic and paraventricular nuclei of neurohypophysis regulate lactation, systemic water homeostasis and nociception.	Water	164-169	arginine vasopressin	Rattus norvegicus	27-38
29862388-3	2018	Due to the efficient binding sites rendered by the pyridyl-based linkers, PCN-604 shows a fast fluorescence response towards trace amounts of Fe3+ ions in water in a fluorescence-quenching mode.	Water	155-160	pericentrin	Homo sapiens	74-77
30109339-2	2018	Phospholipids such as 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), at sufficiently high (~1 muM) concentrations and/or sufficiently long times, turn the liquid crystal director perpendicular to the LC/water interface.	Water	206-211	latexin	Homo sapiens	97-100
31459117-5	2018	The synthesized N@CNS samples showed selective adsorption of organic dye methylene blue (MB) in the presence of methyl orange (MO) as well as Pb(II) ion removal from contaminated water.	Water	179-184	submaxillary gland androgen regulated protein 3B	Homo sapiens	142-148
30039962-5	2018	Energy consumption to treat surface water was 1.1 to 1.3 kWh mol-1 for 1 mM NO3- concentrations, and decreased to 0.19 and 0.12 kWh mol-1 for 10 and 100 mM NaNO3 solutions, respectively.	Water	36-41	NBL1, DAN family BMP antagonist	Homo sapiens	76-79
30045620-2	2018	The proposed microsensors can provide a fast screening of water samples with a qualitative and quantitative analysis for NO2- and NO3- at very low concentration levels.	Water	58-63	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
30039962-7	2018	Conversion of up to 67% of NO3-, with low NO2- (0.7-11 muM) and NH3 formation (&lt;10 muM), and low energy consumption obtained in this study suggest that Pd-Cu/REMs are a promising technology for distributed water treatment.	Water	209-214	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
30074048-5	2018	These results were correlated with their physicochemical properties, namely, solubility, stability and redox behavior by means of UV-vis spectroscopy, NMR or cyclic voltammetry, whereas in DMSO/water, these Pt(iv) complexes transform into biologically less active cis[(NHC)PtX2(DMSO)] species, in the presence of a bioreductant such as glutathione which quickly leads to the formation of a biologically active trans[(NHC)PtX2L] complex.	Water	194-199	paired like homeodomain 2	Homo sapiens	273-277
30052040-2	2018	The emission and circular dichroism data of protein depict the nonmonotonic change suggesting that the structure as well as local environment near the Trp of lysozyme modifies differently for different compositions of the ETH-water mixture.	Water	226-231	lysozyme	Homo sapiens	158-166
32254533-3	2018	In this study, we designed a novel label-free PEC aptamer-based cytosensor for the specific detection of cancer cells such as HeLa cells by using water-dispersible g-C3N4-AgI nanocomposites as visible light-sensitive materials and anti-CEM/PTK7 aptamer as the bio-recognition element.	Water	146-151	protein tyrosine kinase 7 (inactive)	Homo sapiens	240-244
30126206-6	2018	Furthermore, 0.3% GTE in drinking water reduced the average number of tumors per mouse from 4.1 +- 0.5 to 2.6 +- 0.4 and the percentage of PD-L1 positive cells from 9.6% to 2.9%, a decrease of 70%, in lung tumors of A/J mice given a single intraperitoneal injection of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	Water	34-39	CD274 antigen	Mus musculus	139-144
30062348-2	2018	Due to its mobility in the environment it is frequently found in river catchments, often at concentrations exceeding the EU Drinking Water Directive limit of 100 ng L-1 for a single pesticide.	Water	133-138	immunoglobulin kappa variable 1-16	Homo sapiens	165-168
29975516-0	2018	Identification of a Water-Coordinating HER2 Inhibitor by Virtual Screening Using Similarity-Based Scoring.	Water	20-25	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-43
29784373-4	2018	The assessment of alpha fetoprotein (AFP) depends on the quenching of the emission spectrum of the optical sensor at 610 nm in water by the alpha fetoprotein (AFP).	Water	127-132	alpha fetoprotein	Homo sapiens	18-35
29784373-4	2018	The assessment of alpha fetoprotein (AFP) depends on the quenching of the emission spectrum of the optical sensor at 610 nm in water by the alpha fetoprotein (AFP).	Water	127-132	alpha fetoprotein	Homo sapiens	37-40
29975516-2	2018	In this work, a large-scale virtual screen was performed to a novel homology model of HER2, in a hypothesized "fully active" state, that considered water-mediated interactions during the prioritization of compounds for experimental testing.	Water	148-153	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-90
29784373-4	2018	The assessment of alpha fetoprotein (AFP) depends on the quenching of the emission spectrum of the optical sensor at 610 nm in water by the alpha fetoprotein (AFP).	Water	127-132	alpha fetoprotein	Homo sapiens	140-157
29784373-4	2018	The assessment of alpha fetoprotein (AFP) depends on the quenching of the emission spectrum of the optical sensor at 610 nm in water by the alpha fetoprotein (AFP).	Water	127-132	alpha fetoprotein	Homo sapiens	159-162
29730553-4	2018	The SB Cr3+ conjugate in methanol-water (70:30 v/v) allows quantification of Cr3+ ions with limit of detection 0.44 muM and its self-aggregation in high water fraction facilitates extraction of Cr3+ ions with 95% extraction efficiency.	Water	34-39	latexin	Homo sapiens	116-119
29873890-6	2018	The Ir-coordinated assemblies showed a turnover frequency of 13 min-1 , which was comparable to those previously reported for molecular water oxidation catalysts.	Water	136-141	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
29998677-4	2018	Under high turbidity conditions, particulate matter will adsorb part of the Cr(VI) in high turbidity water, thus reducing its interaction with Alb.	Water	101-106	albumin	Homo sapiens	143-146
29975541-6	2018	This work is useful to interpret the interfacial behavior of pyruvic acid under low water activity conditions, typically found in haze aerosols, clouds, and fog waters.	Water	84-89	zinc finger protein, FOG family member 1	Homo sapiens	157-160
30111129-9	2018	For the simple point-charge water model with flexible molecules (SPC/Fw), which combines the long-ranged intermolecular Coulomb potential with hydrogen-oxygen bond-length vibrations, a flexible hydrogen-oxygen-hydrogen bond angle, and Lennard-Jones oxygen-oxygen potentials, we break up the potential into factors containing between two and six particles.	Water	28-33	proline rich protein gene cluster	Homo sapiens	65-68
29775438-1	2018	Conventional graphene oxide (GO) is characterized by low sp2 content in a sp3 rich matrix, which is responsible both for electrical insulation and water super-permeation.	Water	147-152	Sp2 transcription factor	Homo sapiens	57-60
29775438-1	2018	Conventional graphene oxide (GO) is characterized by low sp2 content in a sp3 rich matrix, which is responsible both for electrical insulation and water super-permeation.	Water	147-152	Sp3 transcription factor	Homo sapiens	74-77
30043020-0	2018	Experimental and computational studies on H2O-promoted, Rh-catalyzed transient-ligand-free ortho-C(sp2)-H amidation of benzaldehydes with dioxazolones.	Water	42-45	Sp2 transcription factor	Homo sapiens	97-102
30043020-1	2018	An efficient and convenient ligand-free, rhodium-catalyzed ortho-C(sp2)-H amidation of benzaldehydes with dioxazolones using H2O as the key promoter is described.	Water	125-128	Sp2 transcription factor	Homo sapiens	65-70
29592526-2	2018	The purpose of the study aimed to investigate whether melamine and cyanuric acid induced NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation in the kidney, which may contribute to abnormal water and sodium handling in a rat model.	Water	220-225	NLR family, pyrin domain containing 3	Rattus norvegicus	141-146
29471694-6	2018	The revealed heterogeneous nitrifying population achieved remarkable nitrification, which occurred at low ammonium concentration (14-51 muM) and slightly alkaline pH 7.7-7.9 in chlorine dioxide disinfected water networks.	Water	206-211	latexin	Homo sapiens	136-139
30043025-3	2018	Photocatalytic studies revealed that the highest nuclearity Cd,S-co-rich Cd24 cluster exhibits enhanced photocatalytic water splitting activities compared to the sandwich Cd4(TC4A)2 (Cd4) cluster under the same conditions in the absence of a co-catalyst.	Water	119-124	CD24 molecule	Homo sapiens	73-77
30043025-4	2018	The nanostructure of Cd24 incorporated both peroxyphosphate and peroxyphenoxide groups, which increased the metal coordination numbers to give more labile Cd-O/S bonds and is believed to be the key feature that enables the significant photocatalytic water splitting activities.	Water	250-255	CD24 molecule	Homo sapiens	21-25
29856995-9	2018	In methanol-water phase, CL and CL + CytC mixture form particles of 83.7 +- 9.8 and 71.3 +- 11.6 nm, respectively.	Water	12-17	cytochrome c, somatic	Homo sapiens	37-41
29655107-4	2018	During the UV/H2O2 reaction, all water matrix components acted as radical scavengers in the order of humic acid &gt; CO32-/HCO3- &gt; NO3-.	Water	33-38	NBL1, DAN family BMP antagonist	Homo sapiens	134-137
29653171-1	2018	This study described a curcumin (CUR) loaded bovine serum albumin nanoparticles (BSA@CUR NPs), which could solubilize the poorly water-soluble drug and increase the therapeutic efficacy of the drug.	Water	129-134	albumin	Homo sapiens	58-65
29720354-10	2018	Lysozyme deposited on ionic, high water content lens materials such as etafilcon A show significantly higher surface and bulk activity than many other hydrogel lens materials.	Water	34-39	lysozyme	Homo sapiens	0-8
29771471-1	2018	We describe here the synthesis of water-soluble red/NIR-emissive, boron-dipyrromethene (BODIPY) derivatives displaying optical (absorption and emission) responses in pH range of 4-8.	Water	34-39	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	52-55
29907217-0	2018	Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway.	Water	14-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	88-92
29614421-0	2018	Tuning the morphology and Fe/Ni ratio of a bimetallic Fe-Ni-S film supported on nickel foam for optimized electrolytic water splitting.	Water	119-124	solute carrier family 5 member 5	Homo sapiens	57-61
29778927-6	2018	The corresponding 99mTc complexes were synthesized from fac-[99mTc(CO)3(H2O)3]+, purified by HPLC, and obtained with average 41-76% decay-corrected radiochemical yields and with &gt;99% radiochemical purity.	Water	72-75	FA complementation group C	Homo sapiens	56-59
30082037-4	2018	Here, we present a new analytical method to characterize NO3- stratification using water chemistry sampled during piezometer slug tests.	Water	83-88	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
29694277-9	2018	Average MAP elevations during the poststress period were also significantly reduced after both water and restraint stress in the TrkB.T1 group compared with GFP.	Water	95-100	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	129-133
29907217-17	2018	Moreover, hydrogen-rich water caused Nrf2 to enter the cell nucleus, which resulted in increases in the expression of downstream factors such as HO-1 and NQO1.	Water	24-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	37-41
29907217-17	2018	Moreover, hydrogen-rich water caused Nrf2 to enter the cell nucleus, which resulted in increases in the expression of downstream factors such as HO-1 and NQO1.	Water	24-29	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	154-158
29907217-18	2018	CONCLUSIONS: Our results indicate that hydrogen-rich water has neuroprotective effects against TBI by reducing oxidative stress and activating the Nrf2 pathway.	Water	53-58	NFE2 like bZIP transcription factor 2	Rattus norvegicus	147-151
29956801-14	2018	Furthermore, body weight, brain water content and blood-brain barrier permeability were markedly improved by Tan-IIA treatment of newborn mice following HIE.	Water	32-37	ATPase, class II, type 9A	Mus musculus	113-116
29669261-11	2018	Moreover the Na+/H+ exchanger NHE3, which is involved in Na+ and water absorption in the intestine, was significantly decreased in HFrD-fed Chrebp KO mice.	Water	65-70	MLX interacting protein-like	Mus musculus	140-146
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	Water	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-28
30067237-5	2018	The levels in soil and rock influences the levels in surface and underground water which were between 0.087 and 1.097 mg L-1 for surface water and &lt;0.01-0.46 mg L-1 for underground water, respectively.	Water	77-82	immunoglobulin kappa variable 1-16	Homo sapiens	121-124
30067237-5	2018	The levels in soil and rock influences the levels in surface and underground water which were between 0.087 and 1.097 mg L-1 for surface water and &lt;0.01-0.46 mg L-1 for underground water, respectively.	Water	77-82	immunoglobulin kappa variable 1-16	Homo sapiens	164-167
30067237-5	2018	The levels in soil and rock influences the levels in surface and underground water which were between 0.087 and 1.097 mg L-1 for surface water and &lt;0.01-0.46 mg L-1 for underground water, respectively.	Water	137-142	immunoglobulin kappa variable 1-16	Homo sapiens	121-124
30067237-5	2018	The levels in soil and rock influences the levels in surface and underground water which were between 0.087 and 1.097 mg L-1 for surface water and &lt;0.01-0.46 mg L-1 for underground water, respectively.	Water	137-142	immunoglobulin kappa variable 1-16	Homo sapiens	121-124
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	Water	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-40
30187866-1	2018	OBJECTIVE: To investigate the changes of aldehyde dehydrogenase 2 (ALDH2) expression in H 2O 2inducedcardiomyocytes oxidative stress injury.	Water	88-92	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	41-65
29975048-2	2018	Here, we report identification of a water-containing subpocket as a PDE4-specific pocket for inhibitor binding.	Water	36-41	phosphodiesterase 4A	Homo sapiens	68-72
29975048-6	2018	The structural superposition between the PDE families revealed that this water-containing subpocket is unique to PDE4 and thus valuable for the design of PDE4 selective inhibitors.	Water	73-78	phosphodiesterase 4A	Homo sapiens	113-117
29975048-6	2018	The structural superposition between the PDE families revealed that this water-containing subpocket is unique to PDE4 and thus valuable for the design of PDE4 selective inhibitors.	Water	73-78	phosphodiesterase 4A	Homo sapiens	154-158
29753906-8	2018	ODF imprinted with water-based EM inks contained 0.04 mg EM/6 cm2.	Water	19-24	outer dense fiber of sperm tails 1	Homo sapiens	0-3
30187866-1	2018	OBJECTIVE: To investigate the changes of aldehyde dehydrogenase 2 (ALDH2) expression in H 2O 2inducedcardiomyocytes oxidative stress injury.	Water	88-92	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	67-72
30040486-12	2018	Upregulation of miR-351 increased MFA and MFD, muscle weight water content, Bcl-2 expression levels, and cell viability.	Water	61-66	microRNA 351	Mus musculus	16-23
29965770-5	2018	For its aminopeptidase activity, similar to conventional peptidases, the fourth ligand to the zinc ion is suggested to be an active site water, which is further hydrogen bonded with a downstream glutamic acid, E296.	Water	137-142	carboxypeptidase Q	Homo sapiens	8-22
30090104-9	2018	Following EAU induction, AhR-/- mice had more severe clinical and histopathological manifestations of uveitis than AhR+/+ mice.	Water	10-13	aryl-hydrocarbon receptor	Mus musculus	25-28
29897361-2	2018	The concentration levels of selected antidepressants in wastewater and receiving water were both at ng L-1 level, but those antidepressants that were found in wastewater were typically in a range of one and even two orders of magnitude higher than those that were present in the receiving water except for the concentration levels of paroxetine, norfluoxetine, and nortriptyline.	Water	81-86	L1 cell adhesion molecule	Homo sapiens	103-106
30254813-9	2018	Vasopressin raises epithelial permeability to water in the collecting duct; the amount of luminal osmoles then determines the osmotic gradient for water transport.	Water	46-51	arginine vasopressin	Homo sapiens	0-11
30254813-9	2018	Vasopressin raises epithelial permeability to water in the collecting duct; the amount of luminal osmoles then determines the osmotic gradient for water transport.	Water	147-152	arginine vasopressin	Homo sapiens	0-11
29897361-3	2018	Venlafaxine and its metabolite O-desmethylvenlafaxine were the primary compounds (reaching up to 132.04 and 173.68 ng L-1 as well as 3.03 and 4.53 ng L-1 in wastewater and receiving water, respectively).	Water	162-167	L1 cell adhesion molecule	Homo sapiens	150-153
30087588-10	2018	Activation of ErbB4 by Nrg1beta1 (dosage 150 ng/kg) treatment promoted the neurobehavioral deficit, alleviated the brain water content and reduced albumin leakage 24 and 72 h after SAH.	Water	121-126	erb-b2 receptor tyrosine kinase 4	Rattus norvegicus	14-19
29916244-0	2018	The Role of Water in the Stability of Wild-type and Mutant Insulin Dimers.	Water	12-17	insulin	Homo sapiens	59-66
29906121-0	2018	PPCP Degradation by Chlorine-UV Processes in Ammoniacal Water: New Reaction Insights, Kinetic Modeling, and DBP Formation.	Water	56-61	D-box binding PAR bZIP transcription factor	Homo sapiens	108-111
29969021-0	2018	Kineticomechanistic Study of the Redox pH Cycling Processes Occurring on a Robust Water-Soluble Cyanido-Bridged Mixed-Valence {CoIII/FeII}2 Square.	Water	82-87	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	127-132
30133956-7	2018	CONCLUSIONS: This study examined associations for maternal reports of drinking water filtration and consumption and maternal DBP exposure from drinking water with OFCs in offspring.	Water	79-84	D-box binding PAR bZIP transcription factor	Homo sapiens	125-128
29969021-1	2018	A kineticomechanistic study of reversible electron-transfer processes undergone by the water-soluble, cyanido-bridged mixed-valence [{CoIII{(Me)2(mu-ET)cyclen} }2{(mu-NC)2FeII(CN)4}2]2- square has been carried out.	Water	87-92	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	134-139
29969021-3	2018	The formally endergonic reduction reaction of the fully oxidized ([{CoIII{(Me)2(mu-ET)cyclen} }2{(mu-NC)2FeIII(CN)4}2]) core by water, producing hydrogen peroxide from water even at low pH values, is also a two-step process.	Water	128-133	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	68-73
29949364-3	2018	In the first, the intermediate fac-[Re(CO)3(quin)(H2O)] aqua complex 2 is generated from the fac-[NEt4]2[Re(CO)3Br3] precursor, together with the brominated products fac-[Re(CO)3(quinH)(Br)] 1a and fac-[NEt4][Re(CO)3(quin)(Br)] 1b, in low yield.	Water	50-53	FA complementation group C	Homo sapiens	31-34
29969021-3	2018	The formally endergonic reduction reaction of the fully oxidized ([{CoIII{(Me)2(mu-ET)cyclen} }2{(mu-NC)2FeIII(CN)4}2]) core by water, producing hydrogen peroxide from water even at low pH values, is also a two-step process.	Water	168-173	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	68-73
29949364-3	2018	In the first, the intermediate fac-[Re(CO)3(quin)(H2O)] aqua complex 2 is generated from the fac-[NEt4]2[Re(CO)3Br3] precursor, together with the brominated products fac-[Re(CO)3(quinH)(Br)] 1a and fac-[NEt4][Re(CO)3(quin)(Br)] 1b, in low yield.	Water	50-53	FA complementation group C	Homo sapiens	93-96
29949364-3	2018	In the first, the intermediate fac-[Re(CO)3(quin)(H2O)] aqua complex 2 is generated from the fac-[NEt4]2[Re(CO)3Br3] precursor, together with the brominated products fac-[Re(CO)3(quinH)(Br)] 1a and fac-[NEt4][Re(CO)3(quin)(Br)] 1b, in low yield.	Water	50-53	FA complementation group C	Homo sapiens	93-96
29626600-1	2018	Catalase is a protective enzyme against oxidative stress and converts hydrogen peroxide into water and molecular oxygen.	Water	93-98	catalase	Homo sapiens	0-8
29949364-3	2018	In the first, the intermediate fac-[Re(CO)3(quin)(H2O)] aqua complex 2 is generated from the fac-[NEt4]2[Re(CO)3Br3] precursor, together with the brominated products fac-[Re(CO)3(quinH)(Br)] 1a and fac-[NEt4][Re(CO)3(quin)(Br)] 1b, in low yield.	Water	50-53	FA complementation group C	Homo sapiens	93-96
29627474-10	2018	Asc - and OH degraded CS films showed higher thicknesses, UV-vis light barrier property and water vapor permeability than CS film.	Water	92-97	PYD and CARD domain containing	Homo sapiens	0-3
29986514-3	2018	Based on the active-site difference between PON1 and DFPase, both the wild type and the mutant (a water molecule replacing Asn270 in PON1) models were designed.	Water	98-103	paraoxonase 1	Homo sapiens	44-48
29709810-5	2018	A continuous aeration rate of 0.5 L kg-1 dry matter min-1 gave the best biodrying performance (the highest water-removal rate, biodrying index, and sorting efficiency, 0.5 kg kg-1, 4.12, and 86.87%, respectively, and the highest lower heat value (LHV) and heat utilization rate, 9440 kJ kg-1 and 68.3%, respectively).	Water	107-112	CD59 molecule (CD59 blood group)	Homo sapiens	52-57
29709810-6	2018	There was an optimum aeration rate, water loss reaching a maximum at an aeration rate of 0.5 L kg-1 DM min-1 and not increasing further as the aeration rate increased further.	Water	36-41	CD59 molecule (CD59 blood group)	Homo sapiens	103-108
30050531-13	2018	The granulocytes harvested from lithium heparin blood and water lysis exhibited higher clumping and pre-activation of unstimulated control cells as indicated by isolation of doublet cells, increased CD11b expression, and increased oxidative burst and higher amount of ET-releasing cells.	Water	58-63	integrin subunit alpha M	Bos taurus	199-204
29986514-3	2018	Based on the active-site difference between PON1 and DFPase, both the wild type and the mutant (a water molecule replacing Asn270 in PON1) models were designed.	Water	98-103	paraoxonase 1	Homo sapiens	133-137
31458898-6	2018	The higher compatibility between LSS and enzymatically modified SPI resulted in a positive effect on surface smoothness, water absorption, and mechanical properties of LSS-based films.	Water	121-126	chromogranin A	Homo sapiens	64-67
29986514-4	2018	The results indicated that the substitution of a water molecule for Asn270 in PON1 had little effect on the enzyme activity in kinetics, while being more efficient in thermodynamics, which is essential for DFP hydrolysis.	Water	49-54	paraoxonase 1	Homo sapiens	78-82
30042826-1	2018	Aquaporin 1 (AQP1) is a membrane protein whose main function is to transfer water across cellular membranes.	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
30042826-1	2018	Aquaporin 1 (AQP1) is a membrane protein whose main function is to transfer water across cellular membranes.	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
29679891-7	2018	In highly contaminated water (100 mug L-1), the adsorbent polishes the water quality to well below the current WHO limits.	Water	23-28	L1 cell adhesion molecule	Homo sapiens	38-41
30960675-5	2018	The easily recovered adsorbent was applied to the adsorption of Pb(II) from water.	Water	76-81	submaxillary gland androgen regulated protein 3B	Homo sapiens	64-70
29679891-7	2018	In highly contaminated water (100 mug L-1), the adsorbent polishes the water quality to well below the current WHO limits.	Water	71-76	L1 cell adhesion molecule	Homo sapiens	38-41
29352267-9	2018	However, Caspase-6 mice developed age-dependent episodic and spatial memory deficits identified by novel object recognition, Barnes maze and Morris water maze assays.	Water	148-153	caspase 6	Mus musculus	9-18
29974247-8	2018	Graphical abstract Structures of Pb(II) ions with varying numbers of water molecules in the inner hydration shell.	Water	69-74	submaxillary gland androgen regulated protein 3B	Homo sapiens	33-39
29974256-3	2018	WRIhr is able to monitor flood risk by taking into account the hourly effective precipitation that accumulates the precipitation (Phr) of both current and antecedent hours, while the contributions from the preceding hours is subjected to a time-dependent reduction function that addresses the depletion of water volume by various hydrological processes (e.g., discharge, runoff, evapotranspiration).	Water	306-311	MYC binding protein 2	Homo sapiens	130-133
29674143-6	2018	On the other hand, the bioactivity profile of each type of dry-fermented sausage was evaluated through the measurement of the ACE inhibitory and antioxidant activities in water-soluble peptide extracts fractionated by size-exclusion chromatography.	Water	171-176	angiotensin I converting enzyme	Homo sapiens	126-129
30397527-5	2018	In addition, we have demonstrated that the Lynx1 expression decrease, as well as the blockade of the long-term potentiation underlying learning and memory, caused by Abeta1-42, may be prevented by incubation with a water-soluble Lynx1 analogue.	Water	215-220	Ly6/neurotoxin 1	Homo sapiens	43-48
30397527-5	2018	In addition, we have demonstrated that the Lynx1 expression decrease, as well as the blockade of the long-term potentiation underlying learning and memory, caused by Abeta1-42, may be prevented by incubation with a water-soluble Lynx1 analogue.	Water	215-220	Ly6/neurotoxin 1	Homo sapiens	229-234
30397527-6	2018	Our findings suggest that the water-soluble Lynx1 analogue may be a promising agent for the improvement of cognitive deficits in neurodegenerative diseases.	Water	30-35	Ly6/neurotoxin 1	Homo sapiens	44-49
29587231-6	2018	Thiamethoxam was detected in one grab sample of raw drinking water at a mean concentration of 0.28 mug L-1, which is above the guidelines for drinking water recommended in some jurisdictions, including the European Union directive on pesticide levels &lt;0.1 mug L-1 in water intended for human consumption.	Water	61-66	immunoglobulin kappa variable 1-16	Homo sapiens	103-106
29916690-4	2018	In this work, we present that light-powered TiO2/Pt Janus micromotors have high efficiency for the "on-the-fly" photocatalytic degradation of 2,4-DNT and 2,4,6-TNT in pure water under UV irradiation.	Water	172-177	doughnut on 2	Drosophila melanogaster	146-149
29554623-3	2018	Standards for drinking water range from 2 to 18 microg L-1 in United States and Europe.	Water	23-28	immunoglobulin kappa variable 1-16	Homo sapiens	55-58
29698786-6	2018	Fibrinogen unfolded by the extended (10 min) incubation on GM-HOPG surface in water revealed a different morphology.	Water	78-83	fibrinogen beta chain	Homo sapiens	0-10
28812195-13	2018	However, for the mixed pollutants in tap water, the TOC half-life only increased to 53 min with the most efficient catalyst (P90).	Water	41-46	SEC14 like lipid binding 2	Homo sapiens	37-40
29716740-3	2018	METHODS: HAp particles were added to a GPDM solution for various periods, upon which they were thoroughly washed with ethanol and water prior to being air-dried.	Water	130-135	BAG cochaperone 1	Homo sapiens	9-12
29554623-6	2018	As a result of this presence, and the use of Chile saltpeter as a nitrogen fertilizer, perchlorate in Chile has been found at concentrations as high as 1480 microg L-1 in drinking water, 140 microg/kg-1 in fruits, and 30 microg L-1 in wine.	Water	180-185	immunoglobulin kappa variable 1-16	Homo sapiens	164-167
29602092-8	2018	C18-Mica- 4 was effectively used for the removal of contaminants from four types of water samples.	Water	84-89	Bardet-Biedl syndrome 9	Homo sapiens	0-3
30063865-2	2018	CFTR is an ion channel regulating transport of chloride, bicarbonate, and water, and influencing sodium resorption.	Water	74-79	CF transmembrane conductance regulator	Homo sapiens	0-4
29736649-2	2018	The nitrite and nitrate in drinking water had a concentration range of 0.030-0.113 and 2.41-8.70 mg L-1, with mean values of 0.059 +- 0.014 and 5.25 +- 1.61 mg L-1, respectively.	Water	36-41	immunoglobulin kappa variable 1-16	Homo sapiens	100-103
29654295-5	2018	Blood pressure was measured in anesthetized D2-/- mice treated with etamicastat by gavage, (10 mg/kg), conscious D2-/- mice, and D2+/+ littermates, and mice with the D2R selectively silenced in the kidney, treated with etamicastat in the drinking water (10 mg/kg per day).	Water	247-252	dopamine receptor D2	Mus musculus	166-169
29885273-5	2018	The spring water is oxygen-saturated but still contains relatively elevated concentrations of dissolved iron(II) (17.2 +- 2.8 muM) and sulphide (2.5 +- 0.2 muM) with simultaneously high concentrations of sulphate (8.3 +- 0.04 mM).	Water	11-16	latexin	Homo sapiens	126-129
29885273-5	2018	The spring water is oxygen-saturated but still contains relatively elevated concentrations of dissolved iron(II) (17.2 +- 2.8 muM) and sulphide (2.5 +- 0.2 muM) with simultaneously high concentrations of sulphate (8.3 +- 0.04 mM).	Water	11-16	latexin	Homo sapiens	156-159
30042570-7	2018	The rehydration constant value was found as 16.5 min-1, showing the rapidity with that the water diffused into the powder in the most suitable condition.	Water	91-96	CD59 molecule (CD59 blood group)	Homo sapiens	49-54
31949707-8	2018	Additionally, the ratio of Bax/Bcl-2 was decreased in DeltaIL-17-mutant hepatocyte-induced H2O2.	Water	91-95	BCL2 associated X, apoptosis regulator	Homo sapiens	27-30
31949707-8	2018	Additionally, the ratio of Bax/Bcl-2 was decreased in DeltaIL-17-mutant hepatocyte-induced H2O2.	Water	91-95	BCL2 apoptosis regulator	Homo sapiens	31-36
31949707-9	2018	Finally, Nrf2/keap1 signal pathway was analyzed, the expression of Nrf2 and keap1 was decreased in DeltaIL-17-mutant hepatocyte-induced H2O2.	Water	136-140	NFE2 like bZIP transcription factor 2	Homo sapiens	9-13
31949707-9	2018	Finally, Nrf2/keap1 signal pathway was analyzed, the expression of Nrf2 and keap1 was decreased in DeltaIL-17-mutant hepatocyte-induced H2O2.	Water	136-140	kelch like ECH associated protein 1	Homo sapiens	14-19
31949707-9	2018	Finally, Nrf2/keap1 signal pathway was analyzed, the expression of Nrf2 and keap1 was decreased in DeltaIL-17-mutant hepatocyte-induced H2O2.	Water	136-140	NFE2 like bZIP transcription factor 2	Homo sapiens	67-71
31949707-9	2018	Finally, Nrf2/keap1 signal pathway was analyzed, the expression of Nrf2 and keap1 was decreased in DeltaIL-17-mutant hepatocyte-induced H2O2.	Water	136-140	kelch like ECH associated protein 1	Homo sapiens	76-81
30728987-6	2018	The average OP was 8.90 +- 7.15 and 1.41 +- 0.35 and was 11.4 +- 3.97 and 19.9 +- 8.67 (nmol min-1 mug PM10 -1) for water and methanol extracts on dusty and regular days, respectively, with the lowest value occurring on dusty days.	Water	116-121	CD59 molecule (CD59 blood group)	Homo sapiens	93-98
29583066-8	2018	In this study, we demonstrated that water-soluble peptides derived from the egg yolk stimulate VEGF production and human hair follicle dermal papilla cell growth.	Water	36-41	vascular endothelial growth factor A	Homo sapiens	95-99
29767260-1	2018	Asparaginase like 1 (ASRGL1) protein belongs to the N-terminal nucleophile group, cleaving the isoaspartyl-dipeptides and L-asparagine by adding water.	Water	145-150	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-19
29767260-1	2018	Asparaginase like 1 (ASRGL1) protein belongs to the N-terminal nucleophile group, cleaving the isoaspartyl-dipeptides and L-asparagine by adding water.	Water	145-150	asparaginase and isoaspartyl peptidase 1	Homo sapiens	21-27
29736859-9	2018	PEDF notably reduced cognitive impairment in the Morris water maze (MWM) and significantly downregulated Abeta42 in SAMP8 mice.	Water	56-61	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	0-4
29674031-8	2018	Finally, the sensor showed the practicability of p-NP determination in environmental water samples.	Water	85-90	purine nucleoside phosphorylase	Homo sapiens	49-53
29773682-0	2018	Water structure changes in oxime-mediated reactivation process of phosphorylated human acetylcholinesterase.	Water	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-107
29773682-2	2018	To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-).	Water	23-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-126
29588201-3	2018	MATERIALS AND METHODS: Mice were reared with a high-fat diet containing boiled water extract of BTS for 30 days, and their biochemical parameters as well as the weight and lipid content of feces were measured.	Water	79-84	hydrogen voltage-gated channel 1	Mus musculus	96-99
29773682-2	2018	To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-).	Water	23-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
29727569-5	2018	A cocrystal structure between 43 and DHODH depicts a novel water mediated H-bond interaction with T63.	Water	59-64	dihydroorotate dehydrogenase (quinone)	Homo sapiens	37-42
29947533-1	2018	The endothelin (ET) and prorenin/renin/prorenin receptor (PRR) systems have opposing physiological effects on collecting duct (CD) salt and water reabsorption.	Water	140-145	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	24-56
29947533-1	2018	The endothelin (ET) and prorenin/renin/prorenin receptor (PRR) systems have opposing physiological effects on collecting duct (CD) salt and water reabsorption.	Water	140-145	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	58-61
29949592-10	2018	The case-control investigation showed that 97% (31/32) of cases and 62% (79/128) of controls usually collected water from inside a water-collection site "X" (ORM-H = 16; 95% CI = 2.4-107).	Water	111-116	orosomucoid 1	Homo sapiens	158-161
29863856-6	2018	LDHs intercalated with NO3- ions exhibit a polytype transition from 3 R1 (three-layer rhombohedral polytype) to 1 T (one-layer trigonal polytype) with increasing water content.	Water	162-167	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
29799753-5	2018	H2O promoted the cleavage of beta-(1,4)-glycosidic bonds in hemicellulose derived oligomers to xylose, while the oxygen in the ring of GVL might interact with hydroxyl groups of xylose unit to enhance the dehydration of xylose to furfural, whereas GVL with H2O promoted the depolymerization of lignin to oligomers mainly including beta-O-4" and beta-beta" linkages connecting to G and S units.	Water	0-3	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	29-38
29971013-11	2018	Research in this area is complicated by the fact that the H2O/CO2-transporting function of AQP1 is replaceable by other erythrocyte channels/transporters (e.g., UT-B/GLUT1 for H2O; RhAG for CO2).	Water	58-61	aquaporin 1 (Colton blood group)	Homo sapiens	91-95
29971013-11	2018	Research in this area is complicated by the fact that the H2O/CO2-transporting function of AQP1 is replaceable by other erythrocyte channels/transporters (e.g., UT-B/GLUT1 for H2O; RhAG for CO2).	Water	176-179	aquaporin 1 (Colton blood group)	Homo sapiens	91-95
29971013-12	2018	Recently, using carbonic anhydrase II (CAII)-filled erythrocyte vesicles, AQP1 has been demonstrated to transport water for the CAII-mediated reaction, CO2(g) + H2O   HCO3-(aq) + H+(aq).	Water	114-119	aquaporin 1 (Colton blood group)	Homo sapiens	74-78
29971013-12	2018	Recently, using carbonic anhydrase II (CAII)-filled erythrocyte vesicles, AQP1 has been demonstrated to transport water for the CAII-mediated reaction, CO2(g) + H2O   HCO3-(aq) + H+(aq).	Water	161-164	aquaporin 1 (Colton blood group)	Homo sapiens	74-78
29705649-11	2018	An average recovery of 97.7% and limit of detection of 1-2 mug L-1 were obtained in analyses of surface water.	Water	104-109	immunoglobulin kappa variable 1-16	Homo sapiens	63-66
29799201-0	2018	Rational Design of Co(II) Dominant and Oxygen Vacancy Defective CuCo2O4@CQDs Hollow Spheres for Enhanced Overall Water Splitting and Supercapacitor Performance.	Water	113-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
29863856-7	2018	NO3- ions exhibit a D3 h point group symmetry at low water contents.	Water	53-58	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
29916808-6	2018	Publicly available data were used to characterize sources of PFAS impacts in groundwater and conduct a geospatial case study of potential source locations relative to drinking water aquifers in Rhode Island.	Water	83-88	phosphoribosylformylglycinamidine synthase	Homo sapiens	61-65
29916808-7	2018	DISCUSSION: Challenges in managing PFAS impacts in drinking water arise from the large number of relevant PFASs, unconsolidated information regarding sources, and limited studies on some PFASs.	Water	60-65	phosphoribosylformylglycinamidine synthase	Homo sapiens	35-39
29554533-8	2018	Finally, GBP and GBP-Lactam were found in potable water with concentrations up to 0.64 and 0.07 mug L-1, respectively.	Water	50-55	L1 cell adhesion molecule	Homo sapiens	100-103
30857097-6	2018	Mean PFAS concentrations in water ranged from &lt;LOQ to 38.5ng/L.	Water	28-33	phosphoribosylformylglycinamidine synthase	Homo sapiens	5-9
29635185-3	2018	The detection limits of L1 and L2 were calculated by the fluorescence titration to be 4.13muM and 1.52muM, respectively, which were below the maximum permissive level of Fe3+ and Ni2+ ions in drinking water set by the EPA.	Water	201-206	L1 cell adhesion molecule	Homo sapiens	24-33
30857097-7	2018	PFAS concentrations in water decreased along the gradient and were similar or lower compared to other studies in Europe, Asia and America.	Water	23-28	phosphoribosylformylglycinamidine synthase	Homo sapiens	0-4
30857104-7	2018	The total concentration in treated drinking water (56-57 ng L-1) was at a similar level as upstream from the WWTP (79-90 ng L-1).	Water	44-49	immunoglobulin kappa variable 1-16	Homo sapiens	60-63
30857111-4	2018	The concentration of  PAHs ranged between 2.2 and 182.2ngm-3 in air, between 186 and 8810ngm-2day-1 in atmospheric deposition, and between 0.05 and 65.9ngL-1 in surface water.	Water	169-174	leucine rich repeat containing 4C	Homo sapiens	152-157
29775050-5	2018	These water-suspended PU NPs reduce the nuclear factor-kappaB (NF-kappaB) activation and suppress the subsequent NLR family pyrin domain containing 3 (NLRP3) inflammasome signals.	Water	6-11	nuclear factor kappa B subunit 1	Homo sapiens	40-61
29775050-5	2018	These water-suspended PU NPs reduce the nuclear factor-kappaB (NF-kappaB) activation and suppress the subsequent NLR family pyrin domain containing 3 (NLRP3) inflammasome signals.	Water	6-11	nuclear factor kappa B subunit 1	Homo sapiens	63-72
29775050-5	2018	These water-suspended PU NPs reduce the nuclear factor-kappaB (NF-kappaB) activation and suppress the subsequent NLR family pyrin domain containing 3 (NLRP3) inflammasome signals.	Water	6-11	NLR family pyrin domain containing 3	Homo sapiens	151-156
29763567-2	2018	In this study, we used super-temporal-resolved microscopy (STReM) to study the interfacial kinetics of a globular protein, alpha-lactalbumin (alpha-LA), adsorbing at the water-nylon 6,6 interface.	Water	170-175	lactalbumin alpha	Homo sapiens	123-140
29763567-2	2018	In this study, we used super-temporal-resolved microscopy (STReM) to study the interfacial kinetics of a globular protein, alpha-lactalbumin (alpha-LA), adsorbing at the water-nylon 6,6 interface.	Water	170-175	lactalbumin alpha	Homo sapiens	142-150
29775311-3	2018	This mesophase had previously been observed in monoolein/water systems only on addition of cytochrome c.	Water	57-62	cytochrome c, somatic	Homo sapiens	91-103
29965606-4	2018	SO42-, NO3-, and NH4+ were the major components of the water-soluble ions at the three sampling sites.	Water	55-60	NBL1, DAN family BMP antagonist	Homo sapiens	7-10
29914198-8	2018	The majority of the Extended Spectrum Beta-Lactamase (ESBL)-producing E. coli isolates from river water and sediment in all different seasons belonged to phylogenetic group A or B1.	Water	98-103	EsbL	Escherichia coli	20-52
29914198-8	2018	The majority of the Extended Spectrum Beta-Lactamase (ESBL)-producing E. coli isolates from river water and sediment in all different seasons belonged to phylogenetic group A or B1.	Water	98-103	EsbL	Escherichia coli	54-58
29965613-7	2018	DEHP and DBP were the dominant PAE pollutants in both the water and sediment.	Water	58-63	D-box binding PAR bZIP transcription factor	Homo sapiens	9-12
29789818-3	2018	Natural population analysis shows that the charge distribution of Li3+ becomes seriously uneven upon interaction with five water molecules, so it loses ring conjugation and splits in the lowest-energy isomer of Li3+(H2O)5.	Water	216-219	cytochrome P450 family 4 subfamily F member 22	Homo sapiens	66-69
29789818-1	2018	The interaction of the superalkali cation Li3+ with water molecules, as well as the structures and stability of the resulting water complexes are theoretically studied at the MP2/6-311++G(d,p) level.	Water	52-57	cytochrome P450 family 4 subfamily F member 22	Homo sapiens	42-45
29658886-0	2018	Swelling kinetics and electrical charge transport in PEDOT:PSS thin films exposed to water vapor.	Water	85-90	PSS	Homo sapiens	59-62
29789818-3	2018	Natural population analysis shows that the charge distribution of Li3+ becomes seriously uneven upon interaction with five water molecules, so it loses ring conjugation and splits in the lowest-energy isomer of Li3+(H2O)5.	Water	123-128	cytochrome P450 family 4 subfamily F member 22	Homo sapiens	66-69
29789818-3	2018	Natural population analysis shows that the charge distribution of Li3+ becomes seriously uneven upon interaction with five water molecules, so it loses ring conjugation and splits in the lowest-energy isomer of Li3+(H2O)5.	Water	216-219	cytochrome P450 family 4 subfamily F member 22	Homo sapiens	211-214
29658886-1	2018	We report the swelling kinetics and evolution of the electrical charge transport in poly(3,4-ethylene dioxythiophene) polystyrene sulfonate (PEDOT:PSS) thin films subjected to water vapor.	Water	176-181	PSS	Homo sapiens	147-150
29658886-3	2018	Upon exposure to water vapor, primarily the hygroscopic PSS shell, which surrounds the conducting PEDOT-rich cores, takes up water vapor and subsequently swells.	Water	17-22	PSS	Homo sapiens	56-59
29789818-4	2018	Localized molecular orbital energy decomposition analysis indicates a dominant contribution of electrostatic interactions to the binding of water molecules to Li3+, which is similar to the case of lithium ion hydrates.	Water	140-145	cytochrome P450 family 4 subfamily F member 22	Homo sapiens	159-162
29658886-3	2018	Upon exposure to water vapor, primarily the hygroscopic PSS shell, which surrounds the conducting PEDOT-rich cores, takes up water vapor and subsequently swells.	Water	125-130	PSS	Homo sapiens	56-59
29738664-7	2018	(iii) After 5 years, DOC leaching started to increase as concentrations of NO3-, protons, and polyvalent cations started to decrease in soil water.	Water	141-146	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
29977295-0	2018	Fabrication of AChE/SnO2-cMWCNTs/Cu Nanocomposite-Based Sensor Electrode for Detection of Methyl Parathion in Water.	Water	110-115	acetylcholinesterase (Cartwright blood group)	Homo sapiens	15-19
29977295-1	2018	The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples.	Water	256-261	acetylcholinesterase (Cartwright blood group)	Homo sapiens	37-57
29977295-1	2018	The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples.	Water	256-261	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-63
29977295-2	2018	Working electrode AChE/SnO2-cMWCNTs/Cu exhibited high sensitivity with a linearity range of 1.0 muM to 160 muM and a minimum detection limit of 0.1 muM for MP in water.	Water	162-167	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-22
29384694-1	2018	Aquaporin-5 (AQP5) is a plasma membrane water channel mainly expressed in secretory glands.	Water	40-45	aquaporin 5	Canis lupus familiaris	0-11
29384694-1	2018	Aquaporin-5 (AQP5) is a plasma membrane water channel mainly expressed in secretory glands.	Water	40-45	aquaporin 5	Canis lupus familiaris	13-17
29580388-3	2018	The fabricated macroporous (SGC) scaffold had a greater pore size, higher porosity, higher water retention capacity, slow and sustained enzymatic degradation rate along with higher compressive strength compared to that of non-macroporous (NGC, prepared by conventional freeze drying methodology) scaffold.	Water	91-96	sarcoglycan beta	Homo sapiens	28-31
29540304-7	2018	These findings and our previous studies, which showed that hydrated water molecules around Ile81 and Val83 are expelled when Cyt c forms a complex with CcO, proposed that dehydration of these residues is functionally significant to electron transfer from Cyt c to CcO.	Water	68-73	cytochrome c, somatic	Homo sapiens	125-130
29540304-7	2018	These findings and our previous studies, which showed that hydrated water molecules around Ile81 and Val83 are expelled when Cyt c forms a complex with CcO, proposed that dehydration of these residues is functionally significant to electron transfer from Cyt c to CcO.	Water	68-73	cytochrome c, somatic	Homo sapiens	255-260
29729279-2	2018	CAs also catalyze the reaction of water with other electrophiles such as aromatic esters, sulfates and phosphates, thus contributing to lending to CAs esterase, sulfatase and phosphatase activity, respectively.	Water	34-39	arylsulfatase family member H	Homo sapiens	161-170
29544216-7	2018	From an ecological point of view, PAHs posed a potential risk to drinking water sources as the concentrations exceeded the guideline value of 0.05 mug L-1.	Water	74-79	immunoglobulin kappa variable 1-16	Homo sapiens	151-154
29486360-7	2018	The results indicate that the presence of NOM in water samples may lead to false positive results for AhR activity and false positive results for AR and Nrf2 activity, when assessing inhibition of induced bioactivities from anthropogenic substances.	Water	49-54	androgen receptor	Homo sapiens	146-148
29486360-7	2018	The results indicate that the presence of NOM in water samples may lead to false positive results for AhR activity and false positive results for AR and Nrf2 activity, when assessing inhibition of induced bioactivities from anthropogenic substances.	Water	49-54	NFE2 like bZIP transcription factor 2	Homo sapiens	153-157
29529572-5	2018	The 95th percentile concentrations in freshwater were the same in North America and Europe at 0.30 mug L-1 and were 0.024 mug L-1 and 0.15 mug L-1 in marine water, respectively.	Water	43-48	immunoglobulin kappa variable 1-16	Homo sapiens	103-106
29529572-5	2018	The 95th percentile concentrations in freshwater were the same in North America and Europe at 0.30 mug L-1 and were 0.024 mug L-1 and 0.15 mug L-1 in marine water, respectively.	Water	43-48	immunoglobulin kappa variable 1-16	Homo sapiens	126-129
28593806-2	2018	DHS-USB systems can perform nitrification and denitrification simultaneously, reducing ammonia (NH3) and nitrate (NO3-) toxicity in the water.	Water	136-141	NBL1, DAN family BMP antagonist	Homo sapiens	114-117
29529572-5	2018	The 95th percentile concentrations in freshwater were the same in North America and Europe at 0.30 mug L-1 and were 0.024 mug L-1 and 0.15 mug L-1 in marine water, respectively.	Water	43-48	immunoglobulin kappa variable 1-16	Homo sapiens	126-129
29478202-4	2018	Vasopressin binds to the vasopressin type II receptor (V2R) in the renal collecting ducts and then activates AQP2 phosphorylation and trafficking to increase water reabsorption from urine.	Water	158-163	arginine vasopressin	Homo sapiens	0-11
29478202-4	2018	Vasopressin binds to the vasopressin type II receptor (V2R) in the renal collecting ducts and then activates AQP2 phosphorylation and trafficking to increase water reabsorption from urine.	Water	158-163	arginine vasopressin receptor 2	Homo sapiens	25-58
29502002-8	2018	However some of the more water soluble PFAS were observed in deeper core layers than the time of production could account for, indicating potential diffusion within the sediment.	Water	25-30	phosphoribosylformylglycinamidine synthase	Homo sapiens	39-43
29573474-3	2018	The compounds L1, L2, and D1 could act as Eu3+ ion turn-off fluorescent sensors based on ligand-to-metal binding mechanism in DMSO-H2 O solution (v/v = 1:1, 10 mM Tris, pH = 7.4).	Water	131-135	L1 cell adhesion molecule	Homo sapiens	14-28
29129431-7	2018	The IBU-AgNPs solution showed excellent ultra-rapid catalytic activity for the complete degradation of toxic 4-nitrophenol (4-NPh) into non-toxic 4-aminophenol (4-APh) within 40 s. AgNPs were recovered with the help of water insoluble-room temperature ionic liquid and reused with enhanced catalytic potential.	Water	219-224	acylaminoacyl-peptide hydrolase	Homo sapiens	163-166
29525626-0	2018	Effects on IL-1beta signaling activation induced by water and organic extracts of fine particulate matter (PM2.5) in vitro.	Water	52-57	interleukin 1 beta	Homo sapiens	11-19
29571628-7	2018	Interestingly, the abundance of L-isoAsp is low in the water-soluble cortex despite being the dominant product generated by isomerization of Asp in vitro, suggesting that Protein L-isoaspartyl methyltransferase (PIMT) is active in the cortex and suppresses the accumulation of L-isoAsp.	Water	55-60	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	171-210
29525626-6	2018	The inhibition of signaling molecules suggested that increased IL-1beta was associated with the TLR4/NF-kappaB pathway and NLRP3 inflammasome activation, with a slightly difference between water and organic extracts exposure groups, which was likely the result of different chemical components.	Water	189-194	interleukin 1 beta	Homo sapiens	63-71
29797192-4	2018	Hydro-chemical characterization of fog water from top of the mountain (where capture installation is located) and at the bottom of the mountain (after vertical transportation where an aquaponic system is located) revealed many compositional differences that compromise the use of water.	Water	39-44	zinc finger protein, FOG family member 1	Homo sapiens	35-38
29797192-4	2018	Hydro-chemical characterization of fog water from top of the mountain (where capture installation is located) and at the bottom of the mountain (after vertical transportation where an aquaponic system is located) revealed many compositional differences that compromise the use of water.	Water	280-285	zinc finger protein, FOG family member 1	Homo sapiens	35-38
29582329-7	2018	The elevated As concentrations ranged from 0.31 to 452 mug/L and distributed in depths between 20 and 45 m. As-enriched groundwater is mainly Na-HCO3 type water and characterized by higher pH value, high Na+, low Ca2+, SO42-, and NO3- along with moderate TDS.	Water	126-131	NBL1, DAN family BMP antagonist	Homo sapiens	230-233
29877830-9	2018	This CMOS-enabled oxygen sensor was then employed to test water quality from different sources (tap water, lakes, and rivers).	Water	58-63	SEC14 like lipid binding 2	Homo sapiens	96-99
29735631-3	2018	However, blood pressure increased significantly 1 day after mice with intrarenal silencing of TNF ingested 1% NaCl in the drinking water.	Water	131-136	tumor necrosis factor	Mus musculus	94-97
29266331-5	2018	The CYP19-RT-LAMP assay rapidly identified the LPS-induced downregulation of the CYP19 gene within 30 min at 63 C in a water bath.	Water	119-124	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	81-86
29435998-6	2018	Exposure of immature granulosa cells to the polar fraction exerting 9 ng of 17beta-estradiol equivalents per liter of water of estrogenic activity increased mRNA expression of the key enzymes of progesterone biosynthetic pathway Star and Hsd3b1, but did not alter the level of Cyp19a1 and Lhr.	Water	118-123	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	238-244
29435998-6	2018	Exposure of immature granulosa cells to the polar fraction exerting 9 ng of 17beta-estradiol equivalents per liter of water of estrogenic activity increased mRNA expression of the key enzymes of progesterone biosynthetic pathway Star and Hsd3b1, but did not alter the level of Cyp19a1 and Lhr.	Water	118-123	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	289-292
29266331-5	2018	The CYP19-RT-LAMP assay rapidly identified the LPS-induced downregulation of the CYP19 gene within 30 min at 63 C in a water bath.	Water	119-124	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	4-9
31938420-9	2018	Overexpression of miR-182-5p attenuated H2O2-induced inflammation as reflected by reduction in proinflammatory cytokines in C8-D1A cells.	Water	40-44	microRNA 182	Mus musculus	18-25
31938420-10	2018	Meanwhile, enhanced miR-182-5p expression significantly suppressed H2O2-induced apoptosis.	Water	67-71	microRNA 182	Mus musculus	20-27
31938420-13	2018	More importantly, we found that miR-182-5p blocked phosphorylation of nuclear p65 and promoted phosphorylation of IkappaB-alpha in H2O2-treated C8-D1A cells.	Water	131-135	microRNA 182	Mus musculus	32-39
31938420-13	2018	More importantly, we found that miR-182-5p blocked phosphorylation of nuclear p65 and promoted phosphorylation of IkappaB-alpha in H2O2-treated C8-D1A cells.	Water	131-135	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	114-127
31938420-14	2018	Our results confirm that miR-182-5p alleviates inflammation and apoptosis via inactivation of TLR4/NF-kappaB pathway in an H2O2-induced cell model.	Water	123-127	microRNA 182	Mus musculus	25-32
31938420-14	2018	Our results confirm that miR-182-5p alleviates inflammation and apoptosis via inactivation of TLR4/NF-kappaB pathway in an H2O2-induced cell model.	Water	123-127	toll-like receptor 4	Mus musculus	94-98
31938420-14	2018	Our results confirm that miR-182-5p alleviates inflammation and apoptosis via inactivation of TLR4/NF-kappaB pathway in an H2O2-induced cell model.	Water	123-127	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
29341436-2	2018	Herein, for monitoring COX-2, we synthesize a specific COX-2 probe celecoxib-MPA probe (CMP), based on celecoxib and a water-soluble near-infrared dye dye ICG-Der-02 (MPA).	Water	119-124	prostaglandin-endoperoxide synthase 2	Homo sapiens	55-60
29530595-9	2018	These results suggest that water-bridged complexes are under-represented in CYP structural databases and can have energies similar to other ligation modes.	Water	27-32	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	76-79
29948440-1	2018	The NMR derived translational diffusion coefficients were performed on unlabeled and uniformly labeled 13C,15N human insulin in water, both in neat, with zinc ions only, and in pharmaceutical formulation, containing only m-cresol as phenolic ligand, glycerol and zinc ions.	Water	128-133	insulin	Homo sapiens	117-124
29569221-0	2018	Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl-/water secretion that involves cAMP-dependent activation of CFTR.	Water	77-82	CF transmembrane conductance regulator	Homo sapiens	136-140
29569221-13	2018	JCT can induce a Cl- efflux through the CFTR channel to promote water secretion, and this effect is likely mediated by increased cAMP production.	Water	64-69	CF transmembrane conductance regulator	Homo sapiens	40-44
29567193-4	2018	The analyte solution was injected with an injection valve (2 muL volume) and a ternary solution of water/acetonitrile/ethyl acetate (3:8:2 vol ratio) was delivered as the eluent to the capillary tube at a flow rate of 8.6 muL min-1.	Water	99-104	CD59 molecule (CD59 blood group)	Homo sapiens	226-231
29623566-5	2018	The variation (C/T) of PLCD4 gene affected feed conversion, intramuscular fat and water exudation.	Water	82-87	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	Sus scrofa	23-28
29901649-3	2018	DIAGNOSES: NDI was diagnosed with insignificant response to a water deprivation test after stimulation with vasopressin injection.	Water	62-67	arginine vasopressin receptor 2	Homo sapiens	11-14
29617841-5	2018	Likewise, because of its physical characteristics, which include water solubility and heat stability, alpha-lactalbumin has the potential to be added to food products as a supplemental protein.	Water	65-70	lactalbumin alpha	Homo sapiens	102-119
29388529-1	2018	OBJECTIVE: Differences in bottled v. tap water intake may provide insights into health disparities, like risk of dental caries and inadequate hydration.	Water	41-46	SEC14 like lipid binding 2	Homo sapiens	37-40
29388529-8	2018	Adjusting for covariates, non-Hispanic (NH) Black and Hispanic adults had 0 44 (95 % CI 0 37, 0 53) and 0 55 (95 % CI 0 45, 0 66) times the odds of consuming tap water, and consumed B=-330 (se 45) ml and B=-180 (se 45) ml less tap water than NH White adults, respectively.	Water	162-167	SEC14 like lipid binding 2	Homo sapiens	158-161
29388529-10	2018	In 2007-2010, water filtration was associated with higher odds of drinking plain and tap water.	Water	14-19	SEC14 like lipid binding 2	Homo sapiens	85-88
29388529-12	2018	Water filters may increase tap water consumption.	Water	0-5	SEC14 like lipid binding 2	Homo sapiens	27-30
29388529-12	2018	Water filters may increase tap water consumption.	Water	31-36	SEC14 like lipid binding 2	Homo sapiens	27-30
29799852-15	2018	Foxes living in urban areas are more likely to be exposed to AMR bacteria and resistance drivers from food waste, garbage, sewage, waste water and consumption of contaminated prey compared to foxes living in remote areas.	Water	137-142	G protein-coupled receptor 182	Homo sapiens	61-64
29806909-6	2018	The use of Ni(NO3 )2 or Ni(OAc)2 instead of Cu(NO3 )2 commonly gave a tricyclic metallocage of [Au8 Ni2 (dppe)4 (d-pen)4 ]4+ ([4]4+ ), but a water molecule was accommodated inside the AuI8 NiII2 metallocage.	Water	141-146	NBL1, DAN family BMP antagonist	Homo sapiens	44-50
29610205-6	2018	Upon molecular dynamics simulations of relebactam in the KPC-2 active site, we found that the positioning of active-site water molecules is less favorable for desulfation in the KPC-2 active site than it is in the KPC-2-avibactam complex.	Water	121-126	carbapenem-hydrolyzing beta-lactamase KPC-2	Klebsiella pneumoniae	57-62
29610205-6	2018	Upon molecular dynamics simulations of relebactam in the KPC-2 active site, we found that the positioning of active-site water molecules is less favorable for desulfation in the KPC-2 active site than it is in the KPC-2-avibactam complex.	Water	121-126	carbapenem-hydrolyzing beta-lactamase KPC-2	Klebsiella pneumoniae	178-183
29610205-6	2018	Upon molecular dynamics simulations of relebactam in the KPC-2 active site, we found that the positioning of active-site water molecules is less favorable for desulfation in the KPC-2 active site than it is in the KPC-2-avibactam complex.	Water	121-126	carbapenem-hydrolyzing beta-lactamase KPC-2	Klebsiella pneumoniae	178-183
29689155-3	2018	On the other hand, at the air-water interface, Born-Oppenheimer molecular dynamics simulations suggest that the formation of the fundamental NO3-  (R1)(R2)NH2+ [for NH3, R1 = R2 = H; CH3NH2, R1 = H, R2 = CH3; and (CH3)2NH, R1 = R2 = CH3] ion pairs require the formation of the HNO3  (R1)(R2)NH complexes in the gas-phase prior to their adsorption on the water surface.	Water	30-35	NBL1, DAN family BMP antagonist	Homo sapiens	141-144
29795045-4	2018	Our structural studies show that in hCA VII the network of ordered water molecules, which connects the zinc bound solvent molecule to the proton shuttle His64, is altered compared to hCA II, causing a reduction of the catalytic efficiency.	Water	67-72	carbonic anhydrase 7	Homo sapiens	36-43
29689155-3	2018	On the other hand, at the air-water interface, Born-Oppenheimer molecular dynamics simulations suggest that the formation of the fundamental NO3-  (R1)(R2)NH2+ [for NH3, R1 = R2 = H; CH3NH2, R1 = H, R2 = CH3; and (CH3)2NH, R1 = R2 = CH3] ion pairs require the formation of the HNO3  (R1)(R2)NH complexes in the gas-phase prior to their adsorption on the water surface.	Water	354-359	NBL1, DAN family BMP antagonist	Homo sapiens	141-144
29689155-5	2018	The NO3-  (R1)(R2)NH2+ ion pairs preferentially remain at the interface over the picosecond time scale, where they are stabilized via hydrogen bonding with surface water molecules.	Water	164-169	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
29790558-4	2018	We show that lysozyme recognizes and disperses fullerene in water.	Water	60-65	lysozyme	Homo sapiens	13-21
29739889-5	2018	In the present study, we demonstrate that 24-hours water restriction selectively up-regulated renal medullary expression of FXR with little MCD apoptosis in wild-type mice.	Water	51-56	nuclear receptor subfamily 1, group H, member 4	Mus musculus	124-127
30966601-6	2018	These hydrogels were proved to absorb water with low salinity from brine solution of 2 g L - 1 NaCl and release the absorbed water at relatively low temperature conditions of 50   C. The fraction of the grafted polyacrylic acid and the comb-chain length were varied to understand their influence on the swelling/deswelling behaviour for these hydrogels.	Water	38-43	immunoglobulin kappa variable 1-16	Homo sapiens	89-94
29615320-6	2018	The recoveries of the method for two water samples with spiking levels of 1 and 10 mug L-1 ranged from 83 to 121%.	Water	37-42	immunoglobulin kappa variable 1-16	Homo sapiens	87-90
29658272-2	2018	Arsenite, a widespread contaminant in drinking water, is known to induce oxidative stress and activate the Nrf2-dependent signaling pathway through the stabilization of the Nrf2 protein by inhibiting its ubiquitination via the Cul3-Rbx1-Keap1 (cullin 3, RING-box 1, and Kelch-like ECH-associated protein 1) E3 ubiquitin ligase, and its degradation by the 26S proteasome, though the underlying mechanism, remains elusive.	Water	47-52	NFE2 like bZIP transcription factor 2	Homo sapiens	173-177
29900358-3	2018	Hydrological data encompass the thermohaline properties of the water column (temperature and salinity profiles from CTD casts).	Water	63-68	CTD	Homo sapiens	116-119
29683655-3	2018	Herein, we report an interesting chromogenic interaction between DEA and 4-aminophenol (AP) in the presence of H2O for the first time, which inspires us to develop a novel DEA-participated ALP activity assay by using 4-aminophenyl phosphate (APP) as a substrate.	Water	111-114	alkaline phosphatase, placental	Homo sapiens	189-192
29772789-6	2018	Moreover, it enhanced the expression of aquaporin 1, which is an important water channel that is expressed in the proximal tubules, and reverted aquaporin 1 downregulation induced by IL-1beta/TNFalpha.	Water	75-80	aquaporin 1 (Colton blood group)	Homo sapiens	40-51
29772789-6	2018	Moreover, it enhanced the expression of aquaporin 1, which is an important water channel that is expressed in the proximal tubules, and reverted aquaporin 1 downregulation induced by IL-1beta/TNFalpha.	Water	75-80	interleukin 1 beta	Homo sapiens	183-191
29772789-6	2018	Moreover, it enhanced the expression of aquaporin 1, which is an important water channel that is expressed in the proximal tubules, and reverted aquaporin 1 downregulation induced by IL-1beta/TNFalpha.	Water	75-80	tumor necrosis factor	Homo sapiens	192-200
29518598-7	2018	Consequently, PBSA and BP4 were the most abundant substances in surface water, detected up to 560.4 ng/L.	Water	72-77	BP4	Homo sapiens	14-26
29574146-2	2018	In addition to their status as the primary reducers of H2O2 to water, the oxidized peroxiredoxin byproduct of this reaction has recently been shown capable of participation in H2O2-mediated signaling pathways through disulfide exchange reactions with the transcription factor STAT3.	Water	63-68	peroxiredoxin 2	Homo sapiens	83-96
29574146-2	2018	In addition to their status as the primary reducers of H2O2 to water, the oxidized peroxiredoxin byproduct of this reaction has recently been shown capable of participation in H2O2-mediated signaling pathways through disulfide exchange reactions with the transcription factor STAT3.	Water	63-68	signal transducer and activator of transcription 3	Homo sapiens	276-281
29454924-9	2018	A similar enhancing effect of I- (1 muM) on the transformation of MeP (1 muM) by KMnO4 (12.6 muM) and formation of iodinated aromatic products were also observed in natural water.	Water	173-178	latexin	Homo sapiens	36-39
29658720-0	2018	Adsorption Behavior of Lysozyme at Titanium Oxide-Water Interfaces.	Water	50-55	lysozyme	Homo sapiens	23-31
29448213-9	2018	The removal efficiencies of Pb(II) ion was changed from 83% (wastewater) to 100% (surface water), when the initial concentration was 10 mg L-1.	Water	66-71	submaxillary gland androgen regulated protein 3B	Homo sapiens	28-34
28967484-0	2018	Two-dimensional correlation and codistribution spectroscopy (2DCOS and 2DCDS) analyses of time-dependent ATR IR spectra of d-glucose anomers undergoing mutarotation process in water.	Water	176-181	ATR serine/threonine kinase	Homo sapiens	105-108
29580882-0	2018	Astrocytes and neurons in locus coeruleus mediate restraint water immersion stress-induced gastric mucosal damage through the ERK1/2 signaling pathway.	Water	60-65	mitogen-activated protein kinase 3	Homo sapiens	126-132
29757999-5	2018	The DSC curves of Na-BDP-1 and Na-BDP-2 characterized the endo-effects having a maximum at 95-112  C. Water-soluble Na-BDP-1 was obtained as needle-like crystals, unlike poorly crystalline Na-BDP-2, whereas BDP-1 and BDP-2 aged with time and were isolated as amorphous substances.	Water	102-107	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	Rattus norvegicus	119-124
29757999-5	2018	The DSC curves of Na-BDP-1 and Na-BDP-2 characterized the endo-effects having a maximum at 95-112  C. Water-soluble Na-BDP-1 was obtained as needle-like crystals, unlike poorly crystalline Na-BDP-2, whereas BDP-1 and BDP-2 aged with time and were isolated as amorphous substances.	Water	102-107	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	Rattus norvegicus	119-124
29801371-4	2018	The TOC of de-ionized water is determined to be -1.12 x 10-4/ C, with an accuracy of +-8.26 x 10-6/ C.	Water	22-27	Rho GTPase activating protein 9	Homo sapiens	56-63
29801371-4	2018	The TOC of de-ionized water is determined to be -1.12 x 10-4/ C, with an accuracy of +-8.26 x 10-6/ C.	Water	22-27	Rho GTPase activating protein 9	Homo sapiens	94-101
29649741-3	2018	Both of them can be well docked into the acetyl-lysine (KAc) binding pocket of BRD4, forming key interactions including the critical hydrogen bonds with Asn140 directly and Tyr97 indirectly via a H2O molecule.	Water	196-199	bromodomain containing 4	Homo sapiens	79-83
29747370-17	2018	The average optical density value regression equation of TGF-beta1 in the sterile water control group and the blank control group was 0.04 and 0.06, respectively, and the fitting degree was very poor.	Water	82-87	transforming growth factor beta 1	Homo sapiens	57-66
29454924-9	2018	A similar enhancing effect of I- (1 muM) on the transformation of MeP (1 muM) by KMnO4 (12.6 muM) and formation of iodinated aromatic products were also observed in natural water.	Water	173-178	latexin	Homo sapiens	73-76
29454924-9	2018	A similar enhancing effect of I- (1 muM) on the transformation of MeP (1 muM) by KMnO4 (12.6 muM) and formation of iodinated aromatic products were also observed in natural water.	Water	173-178	latexin	Homo sapiens	73-76
29743334-3	2018	Physiological suppression of vasopressin secretion through high water (HW) intake could achieve a similar effect, necessitating a definitive large-scale trial of HW intake in ADPKD.	Water	64-69	arginine vasopressin	Homo sapiens	29-40
29735925-8	2018	On the other hand, PSf/DMAc membrane pores were finger-like with lower water flux (63.1 &amp;plusmn; 12.4 LMH) and slightly lower solute rejection (96 &amp;plusmn; 2.00%) when compared to PSf/PolarClean membranes.	Water	71-76	insulin like growth factor binding protein 7	Homo sapiens	19-22
29740705-6	2018	Measured NO3- concentrations in surface water are generally low.	Water	40-45	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
29965512-2	2018	In the natural river areas, the mean value of total nitrogen (TN) concentrations in the sediment pore water was about 15.254 mg  L-1, and the total phosphorus (TP) was only 0.654 mg  L-1; while in the reservoirs, the mean value of TN and TP were 6.577 mg  L-1 and 1.432 mg  L-1, respectively.	Water	102-107	immunoglobulin kappa variable 1-16	Homo sapiens	129-132
29697966-1	2018	In this work we present a systematic computational study of the structural and magnetic properties of a layered family of Co(II) hydroxichlorides, obeying to the general formula Co(OH)2- xCl x(H2O) y.	Water	193-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
29697966-6	2018	Moreover, our results suggest that the presence of interlayer water stabilizes the material and at the same time strongly modifies the electronic environment of tetrahedral Co(II), leading to a further drop of the band gap.	Water	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-179
29743519-7	2018	The water-in-oil NEs can be a promising non-invasive medication for ED patients with low response to a phosphodiesterase type 5 (PDE5) inhibitor, thus increasing quality of life in the aging society.	Water	4-9	phosphodiesterase 5A	Homo sapiens	103-127
29743519-7	2018	The water-in-oil NEs can be a promising non-invasive medication for ED patients with low response to a phosphodiesterase type 5 (PDE5) inhibitor, thus increasing quality of life in the aging society.	Water	4-9	phosphodiesterase 5A	Homo sapiens	129-133
29965496-5	2018	In winter, the SO42-, NO3- and NH4+ accounted for 75.7% of the total measured water-soluble ions, followed by 72.8% in spring and 60.2% in summer.	Water	78-83	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
29965503-6	2018	The analysis of the water in the Duihekou reservoir, Siling reservoir, and Lifan reservoir, with lower Cl- concentrations and higher NO3-/Cl- ratios, suggested that chemical fertilizer was the main source, while the analysis of the water in the Qingshan reservoir, with medium Cl- concentrations and NO3-/Cl- ratios, indicated a mixture of NO3- sources.	Water	20-25	NBL1, DAN family BMP antagonist	Homo sapiens	133-136
29717354-2	2018	The results showed that 10% of the water samples exceeded the limit level of Cd established by World Health Organization (WHO) of 0.003 mg L-1.	Water	35-40	immunoglobulin kappa variable 1-16	Homo sapiens	139-142
29723208-4	2018	Mathematical models included in RAC were all validated in previous works, and account for growth and metabolism, based on input data characterizing the forcing functions-water temperature, and food quality/quantity.	Water	170-175	AKT serine/threonine kinase 1	Homo sapiens	32-35
29725770-11	2018	In Ashtamudi, the concentration of NO3--N in overlying water was very less, which suggests reduced nitrogen yield in the estuary from the fluvial input of Kallada River and agricultural runoff.	Water	55-60	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
29676565-8	2018	Groundwaters comply with WHO Guideline Values for drinking water in terms of Cr, Cu, Co, NO2, NO3, Sb, Se, and U.	Water	6-11	NBL1, DAN family BMP antagonist	Homo sapiens	94-97
29102677-9	2018	Finally, based on the recently resolved hCB1 receptor crystal structure, we propose that the differences in RT can be explained by a different binding mode of antagonist 9 from short RT antagonists that is able to displace unfavorable water molecules.	Water	235-240	cannabinoid receptor 1	Homo sapiens	40-44
29514721-7	2018	Insulin sensitivity was higher with decaffeinated coffee than with water (P&lt;0 05).	Water	67-72	insulin	Homo sapiens	0-7
28776866-0	2018	Prenatal androgen receptor activation determines adult alcohol and water drinking in a sex-specific way.	Water	67-72	androgen receptor	Homo sapiens	9-26
29384590-4	2018	Water is required for the alpha-helix to the coiled coil transition, and extra energy is required for the further transition to a beta-sheet structure.	Water	0-5	amyloid beta precursor protein	Homo sapiens	128-134
29465753-7	2018	In the present study, we focused on nES GEMMA of linear and branched, water-soluble polysaccharides forming nanoparticles and were able to obtain spectra for both analyte classes regarding single-charged species.	Water	70-75	nestin	Homo sapiens	36-39
29427949-3	2018	This study used UCMR3 data to investigate three aspects of per- and polyfluoroalkyl substances (PFASs) in drinking water: the occurrence of PFAS and co-contaminant mixtures, trends in PFAS detections relative to PWS characteristics and potential release types, and temporal trends in PFAS occurrence.	Water	115-120	phosphoribosylformylglycinamidine synthase	Homo sapiens	96-100
29472379-1	2018	Desmopressin is a vasopressin analogue selective for type 2 vasopressin receptors that mediate renal water retention.	Water	101-106	arginine vasopressin	Homo sapiens	18-29
29472379-1	2018	Desmopressin is a vasopressin analogue selective for type 2 vasopressin receptors that mediate renal water retention.	Water	101-106	arginine vasopressin	Homo sapiens	60-71
29580487-8	2018	This degradation leads to: i) release of galacturonic acid, ii) lowering of the pH, and iii) water redistribution from the SPI towards the pectin phase.	Water	93-98	chromogranin A	Homo sapiens	123-126
29922432-0	2018	Cyclooxygenase inhibitors combined with deuterium-enriched water augment cytotoxicity in A549 lung cancer cell line via activation of apoptosis and MAPK pathways.	Water	59-64	mitogen-activated protein kinase 3	Homo sapiens	148-152
29765317-2	2018	The present study investigated whether sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA, can mediate its effect through inhibiting HIF-1alpha-induced oxidative stress and inflammation in cigarette smoke (CS)-induced COPD in mice.	Water	80-85	ATPase, class II, type 9A	Mus musculus	57-60
29523003-1	2018	Aquaporin-9 (AQP9) is an aquaglyceroporin that biophysically conducts water, glycerol, and other small solutes.	Water	70-75	aquaporin 9	Homo sapiens	0-11
29523003-1	2018	Aquaporin-9 (AQP9) is an aquaglyceroporin that biophysically conducts water, glycerol, and other small solutes.	Water	70-75	aquaporin 9	Homo sapiens	13-17
29765330-1	2018	It is known that circulating angiotensin II (ANG-II) acts on the circumventricular organs (CVOs), which partially lack a normal blood-brain barrier, to stimulate pressor responses, vasopressin (AVP), and oxytocin (OT) secretion, as well as sodium and water intake.	Water	251-256	angiotensinogen	Rattus norvegicus	29-43
29765330-1	2018	It is known that circulating angiotensin II (ANG-II) acts on the circumventricular organs (CVOs), which partially lack a normal blood-brain barrier, to stimulate pressor responses, vasopressin (AVP), and oxytocin (OT) secretion, as well as sodium and water intake.	Water	251-256	angiotensinogen	Rattus norvegicus	45-51
28796300-3	2018	Studies show that apelin mRNA is highly expressed in the inner stripe of kidney outer medulla, which plays an important role in process of water and sodium balance.	Water	139-144	apelin	Homo sapiens	18-24
28480793-0	2018	Effect of human heat shock protein HspB6 on the solvent features of water in aqueous solutions.	Water	68-73	heat shock protein family B (small) member 6	Homo sapiens	35-40
29572578-8	2018	RESULTS: The severity of EAU in P2rx7 -/- mice was reduced as compared with that in P2rx7 +/+ mice, both clinically and histopathologically.	Water	25-28	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	32-37
29348563-8	2018	In accordance, anti-CXCR3 significantly enhanced SMG expression of tight junction protein claudin-1 and water channel protein aquaporin 5, two molecules that are crucial for normal salivary secretion and can be down-regulated by TNF-alpha.	Water	104-109	small nuclear ribonucleoprotein polypeptide G	Mus musculus	49-52
29572578-12	2018	Furthermore, neutralization of P2RX7 in vivo by BBG suppressed EAU clinically and histopathologically.	Water	63-66	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	31-36
29348563-8	2018	In accordance, anti-CXCR3 significantly enhanced SMG expression of tight junction protein claudin-1 and water channel protein aquaporin 5, two molecules that are crucial for normal salivary secretion and can be down-regulated by TNF-alpha.	Water	104-109	tumor necrosis factor	Mus musculus	229-238
29735470-7	2018	At the same time, the average TNF-a, IL-1 and IL-6 water in the observation group were significantly lower than that of the control group, proving that the treatment regimen could reduce the inflammatory response.	Water	51-56	interleukin 6	Homo sapiens	46-50
28913879-7	2018	RESULTS: Numerical simulation suggests that the DIR technique provides perfect nulling of muscle and fat as well as efficient suppression of other long T2 tissues with T1 values between fat and water or those above water.	Water	194-199	arginine vasopressin receptor 2	Homo sapiens	48-51
28913879-7	2018	RESULTS: Numerical simulation suggests that the DIR technique provides perfect nulling of muscle and fat as well as efficient suppression of other long T2 tissues with T1 values between fat and water or those above water.	Water	215-220	arginine vasopressin receptor 2	Homo sapiens	48-51
29890592-1	2018	We assess the use of fluorescent dissolved organic matter at excitation-emission wavelengths of 280nm and 360nm, termed tryptophan-like fluorescence (TLF), as an indicator of faecally contaminated drinking water.	Water	206-211	TATA-box binding protein like 1	Homo sapiens	120-148
29223084-6	2018	Despite this addition, water exiting the wetlands treated with coagulants had lower DOC and DBP precursor concentrations relative to untreated source water.	Water	23-28	D-box binding PAR bZIP transcription factor	Homo sapiens	92-95
29223084-8	2018	50-70% reduction in DOC and DBP precursor concentrations) when inflow water DOC concentrations were higher and wetland DOC production was lower.	Water	70-75	D-box binding PAR bZIP transcription factor	Homo sapiens	28-31
29890592-1	2018	We assess the use of fluorescent dissolved organic matter at excitation-emission wavelengths of 280nm and 360nm, termed tryptophan-like fluorescence (TLF), as an indicator of faecally contaminated drinking water.	Water	206-211	TATA-box binding protein like 1	Homo sapiens	150-153
29611289-6	2018	The results show that the apparent kinetic rate constant of catalytic reduction of 4-nitrophenol (4-NP) in water by reductant sodium borohydride (NaBH4 ), is ranging from 3.7 to 37.9 min-1 at temperatures from 20 to 45 oC and the molar ratio of NaBH4 to 4-NP from 100:1 to 500:1.	Water	107-112	CD59 molecule (CD59 blood group)	Homo sapiens	183-188
29890613-10	2018	The plan was to make the mass to concentration tie-in for the selected analyzed compounds (Benzene, Toluene, and Total Petroleum Hydrocarbons) from the PSG in mass (nanograms) with both the soil and water samples in concentration.	Water	199-204	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	152-155
29629770-0	2018	Adsorption of Denaturated Lysozyme at the Air-Water Interface: Structure and Morphology.	Water	46-51	lysozyme	Homo sapiens	26-34
29629770-1	2018	The application of protein deuteration and high flux neutron reflectometry has allowed a comparison of the adsorption properties of lysozyme at the air-water interface from dilute solutions in the absence and presence of high concentrations of two strong denaturants: urea and guanidine hydrochloride (GuHCl).	Water	152-157	lysozyme	Homo sapiens	132-140
29655279-5	2018	In this study, a kind of 1D flexible caterpillar-like GNAs (CL-GNAs) with ultrasmall nanogaps, good water solubility, and good stability is developed.	Water	100-105	GNAS complex locus	Homo sapiens	54-58
29655279-5	2018	In this study, a kind of 1D flexible caterpillar-like GNAs (CL-GNAs) with ultrasmall nanogaps, good water solubility, and good stability is developed.	Water	100-105	GNAS complex locus	Homo sapiens	63-67
29331917-8	2018	Using a flow rate of 5mLmin-1 and an initial concentration of As(III) 200microgL-1, gave an oxidation percentage of As(III) of up to 72%, showing a simple and economical alternative to the oxidation step of As(III) to As(V) in the treatment of water contaminated with arsenic.	Water	244-249	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	218-223
29499256-1	2018	Nephrogenic diabetes insipidus (NDI), a rare cause of polyuria and polydipsia in children, is usually managed with medications and careful monitoring of water intake.	Water	153-158	arginine vasopressin receptor 2	Homo sapiens	32-35
29701941-6	2018	METHODS: Hs578t cells were exposed to various signaling pathway stimulants or neonicotinoids for 24 h. Promoter-specific expression of CYP19 was determined by real-time quantitative polymerase chain reaction and catalytic activity of aromatase by tritiated water release assay.	Water	257-262	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	135-140
29712953-4	2018	Additionally, exposure to original surface water sample collected from backwater area altered the expressions of sod-2, sod-5, clk-1, and mev-1.	Water	43-48	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	138-143
29755973-2	2018	In addition to enabling water flux, mammalian Aquaporin-1 (AQP1) channels activated by cyclic GMP can carry non-selective monovalent cation currents, selectively blocked by arylsulfonamide compounds AqB007 (IC50 170 muM) and AqB011 (IC50 14 muM).	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	46-57
29755973-2	2018	In addition to enabling water flux, mammalian Aquaporin-1 (AQP1) channels activated by cyclic GMP can carry non-selective monovalent cation currents, selectively blocked by arylsulfonamide compounds AqB007 (IC50 170 muM) and AqB011 (IC50 14 muM).	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	59-63
29679033-3	2018	In this study, it is demonstrated PIA water dramatically induced a major antioxidative Nrf2 gene in human gingival fibroblasts which further confirms its cellular antioxidative and anti-inflammatory properties.	Water	38-43	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
29713372-12	2018	FCR &gt; 0.1 mg/L increased from 4.1% to 27.9% over this time, with Water Safety Plan (WSP) programming strongly associated with FCR (mOR: 24.16; 95% CI: 5.93-98.5).	Water	68-73	opioid receptor, mu 1	Mus musculus	134-137
29584430-2	2018	Specific inhibition of the BimBH3-Bcl2A1 protein-protein interaction was obtained in vitro and in cancer cells by shortening the peptide to 14 residues, inserting two cyclization constraints to stabilize a water-stable alpha-helix, and incorporating an N-terminal acrylamide electrophile for selective covalent bonding to Bcl2A1.	Water	206-211	BCL2 related protein A1	Homo sapiens	34-40
29620114-2	2018	Herein, we report a highly water-soluble Eu(DPA)3@Lap nanohybrid material for the rapid and selective assay of PPi and ALP through a luminescence off-on recognition process.	Water	27-32	alkaline phosphatase, placental	Homo sapiens	119-122
29408119-0	2018	Removal of aniline from air and water by polymers of intrinsic microporosity (PIM-1) electrospun ultrafine fibers.	Water	32-37	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	78-83
29652825-7	2018	The results showed the lysozyme loaded composite gel had high porosity, excellent water absorption property, and good antimicrobial activities against Escherichia coli and Staphylococcus aureus.	Water	82-87	lysozyme	Homo sapiens	23-31
29650969-2	2018	Congenital NDI is mainly caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R), leading to impaired aquaporin-2 (AQP2) water channel activity.	Water	143-148	arginine vasopressin receptor 2	Homo sapiens	69-101
29547289-8	2018	The results showed that the trapped decane molecules provide stability to the Rha-C10-C10 aggregates of size N = 50 which are shown to be unstable in our previous study and allow for the growth of larger aggregates than pure Rha-C10-C10 in water.	Water	240-245	homeobox C10	Homo sapiens	82-85
29547289-8	2018	The results showed that the trapped decane molecules provide stability to the Rha-C10-C10 aggregates of size N = 50 which are shown to be unstable in our previous study and allow for the growth of larger aggregates than pure Rha-C10-C10 in water.	Water	240-245	homeobox C10	Homo sapiens	86-89
29547289-8	2018	The results showed that the trapped decane molecules provide stability to the Rha-C10-C10 aggregates of size N = 50 which are shown to be unstable in our previous study and allow for the growth of larger aggregates than pure Rha-C10-C10 in water.	Water	240-245	homeobox C10	Homo sapiens	86-89
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Water	203-208	immunoglobulin kappa variable 1-16	Homo sapiens	47-50
29547289-8	2018	The results showed that the trapped decane molecules provide stability to the Rha-C10-C10 aggregates of size N = 50 which are shown to be unstable in our previous study and allow for the growth of larger aggregates than pure Rha-C10-C10 in water.	Water	240-245	homeobox C10	Homo sapiens	86-89
29553731-0	2018	Dynamic Mechanism of a Fluorinated Oxime Reactivator Unbinding from AChE Gorge in Polarizable Water.	Water	94-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
29335217-6	2018	According to world health organization (WHO) in guidelines for drinking-water quality, the mercury level in natural occurring ground and surface water is about ~0.5 muM (mug/L).	Water	145-150	latexin	Homo sapiens	165-168
29527894-5	2018	In inland surface water, the annual average (AA)-EQS of the EU Water Framework Directive of 0.65 ng L-1 for  PFOS (linear and branched isomers) was exceeded in 46% of the samples.	Water	63-68	immunoglobulin kappa variable 1-16	Homo sapiens	100-103
29527894-6	2018	The drinking water guideline value of 90 ng L-1 for  11PFASs recommended by the Swedish EPA was exceeded in 3% of the water samples from drinking water sources ( n = 169).	Water	13-18	immunoglobulin kappa variable 1-16	Homo sapiens	44-47
29527894-6	2018	The drinking water guideline value of 90 ng L-1 for  11PFASs recommended by the Swedish EPA was exceeded in 3% of the water samples from drinking water sources ( n = 169).	Water	118-123	immunoglobulin kappa variable 1-16	Homo sapiens	44-47
29540552-9	2018	Indeed, mice with defects in JIP1-mediated JNK activation display enhanced memory in hippocampus-dependent tasks, such as contextual fear conditioning and Morris water maze, indicating that JIP1-JNK constrains spatial memory.	Water	162-167	mitogen-activated protein kinase 8 interacting protein 1	Mus musculus	29-33
29540552-9	2018	Indeed, mice with defects in JIP1-mediated JNK activation display enhanced memory in hippocampus-dependent tasks, such as contextual fear conditioning and Morris water maze, indicating that JIP1-JNK constrains spatial memory.	Water	162-167	mitogen-activated protein kinase 8 interacting protein 1	Mus musculus	190-194
29539260-9	2018	Our simulation shows that (PEG) n-CBG initially form aggregates, mostly with the PEG in the core and the hydrophilic CBG groups pointing toward water; then the aggregates approach the polyP and sandwich the polyP to form a complex.	Water	144-149	serpin family A member 6	Homo sapiens	34-37
29539260-9	2018	Our simulation shows that (PEG) n-CBG initially form aggregates, mostly with the PEG in the core and the hydrophilic CBG groups pointing toward water; then the aggregates approach the polyP and sandwich the polyP to form a complex.	Water	144-149	serpin family A member 6	Homo sapiens	117-120
29288915-0	2018	Highly porous copper ferrite foam: A promising adsorbent for efficient removal of As(III) and As(V) from water.	Water	105-110	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	94-99
29675407-1	2018	Aquaporins comprise a family of 13 members of water channels (AQP0-12) that facilitate a rapid transport of water across cell membranes.	Water	46-51	major intrinsic protein of lens fiber	Mus musculus	62-69
29675407-1	2018	Aquaporins comprise a family of 13 members of water channels (AQP0-12) that facilitate a rapid transport of water across cell membranes.	Water	108-113	major intrinsic protein of lens fiber	Mus musculus	62-69
29517896-5	2018	A high water recovery with a negligible reverse solute flux was achieved for NMe4-Cr-OA in electroplating wastewater treatment via the FO process.	Water	7-12	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	77-81
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Water	203-208	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Water	203-208	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Water	203-208	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Water	203-208	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Water	300-305	immunoglobulin kappa variable 1-16	Homo sapiens	47-50
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Water	300-305	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Water	300-305	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Water	300-305	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Water	300-305	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29615767-6	2018	Such the water soluble graphene can be stored in the form of dispersion (~0.55 g L-1) or filter cake for more than 6 months without the risk of re-stacking.	Water	9-14	immunoglobulin kappa variable 1-16	Homo sapiens	81-84
29553723-2	2018	Upon heating/cooling, the water molecules which are coordinated to a pair of crystallographically symmetric Co(II) ions are removed/recovered discretely in two steps, giving [Co3(pimda)2(H2O)4] (2) and [Co3(pimda)2(H2O)3] (3), which is evidenced by the reversible single-crystal-to-single-crystal (SCSC) structural transformations.	Water	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
29480817-6	2018	In contrast, nonpersistent vaccine formulations based on dendritic cells, viral vectors, or water-soluble peptides potently synergized with checkpoint blockade of both CTLA-4 and PD-L1 and induced complete tumor regression, including in settings of primary resistance to dual checkpoint blockade.	Water	92-97	CD274 antigen	Mus musculus	179-184
29553723-2	2018	Upon heating/cooling, the water molecules which are coordinated to a pair of crystallographically symmetric Co(II) ions are removed/recovered discretely in two steps, giving [Co3(pimda)2(H2O)4] (2) and [Co3(pimda)2(H2O)3] (3), which is evidenced by the reversible single-crystal-to-single-crystal (SCSC) structural transformations.	Water	187-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
29581173-1	2018	Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) chloride channel plays a critical role in regulating transepithelial movement of water and electrolyte in exocrine tissues.	Water	145-150	CF transmembrane conductance regulator	Homo sapiens	0-56
29581173-1	2018	Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) chloride channel plays a critical role in regulating transepithelial movement of water and electrolyte in exocrine tissues.	Water	145-150	CF transmembrane conductance regulator	Homo sapiens	58-62
29424242-4	2018	Many proteolytic mechanisms have been proposed for Rce1, but sequence alignment, mutational studies, topology, and recent crystallographic data point to a novel mechanism involving a glutamate-activated water and an oxyanion hole.	Water	203-208	Ras converting CAAX endopeptidase 1	Homo sapiens	51-55
29674767-1	2018	The primary toxicity of hydrogen peroxide results from its interaction with catalase, which liberates water and oxygen.	Water	102-107	catalase	Homo sapiens	76-84
29150771-3	2018	The total concentrations of PFCs (Sigma PFCs) ranged from 0.143 to 1.41 ng L-1 in water samples.	Water	82-87	immunoglobulin kappa variable 1-16	Homo sapiens	75-78
29039044-2	2018	The variation of radon concentration in water ranged from 1.44 +- 0.31 to 63.64 +- 2.88 Bq L-1, with a mean value of 28.73 Bq L-1 using RAD7 and 0.64 +- 0.28 to 52.65 +- 2.50 Bq L-1, with a mean value of 20.30 Bq L-1 using Smart RnDuo monitor, respectively.	Water	40-45	immunoglobulin kappa variable 1-16	Homo sapiens	91-94
29039044-2	2018	The variation of radon concentration in water ranged from 1.44 +- 0.31 to 63.64 +- 2.88 Bq L-1, with a mean value of 28.73 Bq L-1 using RAD7 and 0.64 +- 0.28 to 52.65 +- 2.50 Bq L-1, with a mean value of 20.30 Bq L-1 using Smart RnDuo monitor, respectively.	Water	40-45	immunoglobulin kappa variable 1-16	Homo sapiens	126-129
29039044-2	2018	The variation of radon concentration in water ranged from 1.44 +- 0.31 to 63.64 +- 2.88 Bq L-1, with a mean value of 28.73 Bq L-1 using RAD7 and 0.64 +- 0.28 to 52.65 +- 2.50 Bq L-1, with a mean value of 20.30 Bq L-1 using Smart RnDuo monitor, respectively.	Water	40-45	immunoglobulin kappa variable 1-16	Homo sapiens	126-129
29039044-2	2018	The variation of radon concentration in water ranged from 1.44 +- 0.31 to 63.64 +- 2.88 Bq L-1, with a mean value of 28.73 Bq L-1 using RAD7 and 0.64 +- 0.28 to 52.65 +- 2.50 Bq L-1, with a mean value of 20.30 Bq L-1 using Smart RnDuo monitor, respectively.	Water	40-45	immunoglobulin kappa variable 1-16	Homo sapiens	126-129
29417482-7	2018	However, addition of 50 mg L-1 fullerene C60 to the wastewater decreased the values for water uptake and nitrogen recovery.	Water	57-62	immunoglobulin kappa variable 1-16	Homo sapiens	27-30
29274533-8	2018	This work disclosed the correlation of the superior As(V) adsorption ability with the surface hydroxyl groups in defective MgFe2O4, and propose MgFe2O4 as a potential candidate for the remediation of As-contaminated water.	Water	216-221	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	52-57
29421402-8	2018	Interactions between SNPs and water As on skin lesion risk were suggestive for three variants: the G allele of MTRR rs1801394 and T allele of FOLR1 rs1540087 were associated with lower odds of skin lesions with lower As (&lt;=50 mug/L), and the T allele of TYMS rs1001761 was associated with higher odds of skin lesions with higher As.	Water	30-35	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	111-115
31938330-0	2018	miR-190 protects cardiomyocytes from apoptosis induced by H2O2 through targeting MAPK8 and regulating MAPK8/ERK signal pathway.	Water	58-62	Eph receptor B1	Rattus norvegicus	108-111
31938330-9	2018	In conclusion, these data suggest that miR-190 protects against oxidative stress injury of H9c2 cells induced by H2O2 through inhibiting MAPK8 expression and the MAPK8/ERK pathway.	Water	113-117	Eph receptor B1	Rattus norvegicus	168-171
29459481-8	2018	These data implicate the activities of EPHX2 and EPHX3 in production of the linoleate triols detected as end products of the 12R-LOX pathway in the epidermis and implicate their functioning in formation of the mammalian water permeability barrier.	Water	220-225	epoxide hydrolase 3	Homo sapiens	49-54
28984032-10	2018	Serum TT3 AUC concentrations (0-4 hr) of TRH stimulation tests were greater (p &lt; .05) by 16% with water compared to control treatments.	Water	101-106	thyrotropin releasing hormone	Felis catus	41-44
29577293-4	2018	Water absorption property, protein solubility, Fourier transform infrared (FTIR) and X-ray diffraction (XRD) spectroscopy revealed that enzyme treated SPI film matrix in the molecular structure level, resulted in the changes in physicochemical properties.	Water	0-5	chromogranin A	Homo sapiens	151-154
29393494-2	2018	Aquaporin 1 (AQP1) is a 28-kDa water channel formed of six transmembrane domains on the cell membrane.	Water	31-36	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
29676755-2	2018	The objective of this study was to systematically review the evidence in associated with drinking water DBP exposure in relation to adverse pregnancy outcomes.	Water	98-103	D-box binding PAR bZIP transcription factor	Homo sapiens	104-107
29393494-2	2018	Aquaporin 1 (AQP1) is a 28-kDa water channel formed of six transmembrane domains on the cell membrane.	Water	31-36	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
29389842-1	2018	A high activity of cytochrome P450 2D6 (CYP2D6) reportedly leads to toxicity of dihydrocodeine/codeine by increasing toxic potential of their metabolite dihydromorphine/morphine, which are further metabolized to highly active dihydromorphine 6-O-glucuronide and the less active morphine 3-O-glucorinide but rapidly excreted into urine as water-soluble forms.	Water	338-343	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	19-38
29076774-9	2018	The majority of the institutions chose a difference of 10C between the water tank and core temperatures as the temperature gradient during rewarming.	Water	71-76	Rho GTPase activating protein 9	Homo sapiens	55-58
29055589-2	2018	In this study, the seasonal and spatial variations of sediment oxygen demand (SOD) and the influencing factors were explored using pore water chemistry for the weir-impounded rivers.	Water	136-141	superoxide dismutase 1	Homo sapiens	78-81
29055589-9	2018	Principal component analysis revealed the mutual contributions of nitrogen-associated processes and the organic composition in pore water to increasing SOD levels.	Water	132-137	superoxide dismutase 1	Homo sapiens	152-155
29055589-10	2018	NH3-N in sediment pore water alone could be a good predictor for SOD.	Water	23-28	superoxide dismutase 1	Homo sapiens	65-68
29165649-6	2018	Results of 190 water samples shows radon concentrations from 0.2 to 28.0 Bq L-1, with a geometric mean of 5.0 Bq L-1.	Water	15-20	L1 cell adhesion molecule	Homo sapiens	76-79
29165649-6	2018	Results of 190 water samples shows radon concentrations from 0.2 to 28.0 Bq L-1, with a geometric mean of 5.0 Bq L-1.	Water	15-20	L1 cell adhesion molecule	Homo sapiens	113-116
29149751-2	2018	We show that the breakthrough of reverse osmosis-derived freshwater in the largely engineered water cycle of the greater Tel Aviv region (Dan Region) has profoundly changed previous isotope fingerprints.	Water	62-67	NBL1, DAN family BMP antagonist	Homo sapiens	138-141
29389842-1	2018	A high activity of cytochrome P450 2D6 (CYP2D6) reportedly leads to toxicity of dihydrocodeine/codeine by increasing toxic potential of their metabolite dihydromorphine/morphine, which are further metabolized to highly active dihydromorphine 6-O-glucuronide and the less active morphine 3-O-glucorinide but rapidly excreted into urine as water-soluble forms.	Water	338-343	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	40-46
29485857-8	2018	Furthermore, the presence of a water molecule interacting with the PMPC phosphonate and pyridine N-C2 pi-bond, as well as the nucleophilic hydroxide, suggests that the PMPC binds to the MBL active site as its hydrate.	Water	31-36	mannose-binding lectin family member 3, pseudogene	Homo sapiens	186-189
29306702-6	2018	Clinically important taxa, such as Acinetobacter and Staphylococcus, increased in feces of mice that drank tap water and in mucosa-adhered samples of animals from disinfected and tap water groups.	Water	111-116	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	107-110
29261513-0	2018	High-content hydrogen water-induced downregulation of miR-136 alleviates non-alcoholic fatty liver disease by regulating Nrf2 via targeting MEG3.	Water	22-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-125
29512390-8	2018	The inhibition and activation can be ascribed to the different coordination chemistries of Zn2+ and Mg2+ ions and the orientation of the metal-coordinated water molecules.	Water	155-160	mucolipin TRP cation channel 1	Homo sapiens	100-103
29306702-6	2018	Clinically important taxa, such as Acinetobacter and Staphylococcus, increased in feces of mice that drank tap water and in mucosa-adhered samples of animals from disinfected and tap water groups.	Water	111-116	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	54-57
29510055-6	2018	Critical insight reveals that the observed plane specificity is strongly correlated with the number and their instantaneous fluctuations of clathrate water forming hydrogen bonds with both ice binding surface (IBS) of AFP and ice surface, thus anchoring AFP to the ice surface.	Water	150-155	alpha fetoprotein	Homo sapiens	218-221
29510055-6	2018	Critical insight reveals that the observed plane specificity is strongly correlated with the number and their instantaneous fluctuations of clathrate water forming hydrogen bonds with both ice binding surface (IBS) of AFP and ice surface, thus anchoring AFP to the ice surface.	Water	150-155	alpha fetoprotein	Homo sapiens	254-257
29383335-3	2018	These nanobiointerfaces are prepared through the self-assembly of oleic acid (OA) with the human cathelicidin LL-37 in excess water.	Water	126-131	cathelicidin antimicrobial peptide	Homo sapiens	110-115
29687903-6	2018	In many cell types that have lost water, NKCC is activated to help the cells recover their volume.	Water	34-39	solute carrier family 12 member 1	Homo sapiens	41-45
29474082-6	2018	Because Pt-H is transiently involved in catalytic water splitting on Pt, the present spectroscopic characterization paves the way for in-operando kinetic studies of such reactions.	Water	50-55	parathyroid hormone	Homo sapiens	8-12
29556787-6	2018	Thirdly, the cooperative action of Ang II acting on AT1R and AVP stimulating both V1aR and V2 receptors in the kidney is necessary for the appropriate regulation of renal blood flow and the efficient resorption of sodium and water.	Water	225-230	angiotensinogen	Homo sapiens	35-41
29556787-6	2018	Thirdly, the cooperative action of Ang II acting on AT1R and AVP stimulating both V1aR and V2 receptors in the kidney is necessary for the appropriate regulation of renal blood flow and the efficient resorption of sodium and water.	Water	225-230	arginine vasopressin	Homo sapiens	61-64
29556787-8	2018	In this review, we (1) point attention to the role of the cooperative action of Ang II and AVP for the regulation of blood pressure and the water-electrolyte balance under physiological conditions, (2) present the subcellular mechanisms underlying interactions of these two peptides, and (3) provide evidence that dysregulation of the cooperative action of Ang II and AVP significantly contributes to the development of disturbances in the regulation of blood pressure and the water-electrolyte balance in cardiovascular diseases.	Water	140-145	arginine vasopressin	Homo sapiens	80-94
29556787-8	2018	In this review, we (1) point attention to the role of the cooperative action of Ang II and AVP for the regulation of blood pressure and the water-electrolyte balance under physiological conditions, (2) present the subcellular mechanisms underlying interactions of these two peptides, and (3) provide evidence that dysregulation of the cooperative action of Ang II and AVP significantly contributes to the development of disturbances in the regulation of blood pressure and the water-electrolyte balance in cardiovascular diseases.	Water	140-145	angiotensinogen	Homo sapiens	80-86
29556787-8	2018	In this review, we (1) point attention to the role of the cooperative action of Ang II and AVP for the regulation of blood pressure and the water-electrolyte balance under physiological conditions, (2) present the subcellular mechanisms underlying interactions of these two peptides, and (3) provide evidence that dysregulation of the cooperative action of Ang II and AVP significantly contributes to the development of disturbances in the regulation of blood pressure and the water-electrolyte balance in cardiovascular diseases.	Water	140-145	arginine vasopressin	Homo sapiens	91-94
29556787-8	2018	In this review, we (1) point attention to the role of the cooperative action of Ang II and AVP for the regulation of blood pressure and the water-electrolyte balance under physiological conditions, (2) present the subcellular mechanisms underlying interactions of these two peptides, and (3) provide evidence that dysregulation of the cooperative action of Ang II and AVP significantly contributes to the development of disturbances in the regulation of blood pressure and the water-electrolyte balance in cardiovascular diseases.	Water	477-482	arginine vasopressin	Homo sapiens	80-94
29556787-8	2018	In this review, we (1) point attention to the role of the cooperative action of Ang II and AVP for the regulation of blood pressure and the water-electrolyte balance under physiological conditions, (2) present the subcellular mechanisms underlying interactions of these two peptides, and (3) provide evidence that dysregulation of the cooperative action of Ang II and AVP significantly contributes to the development of disturbances in the regulation of blood pressure and the water-electrolyte balance in cardiovascular diseases.	Water	477-482	angiotensinogen	Homo sapiens	80-86
29556787-8	2018	In this review, we (1) point attention to the role of the cooperative action of Ang II and AVP for the regulation of blood pressure and the water-electrolyte balance under physiological conditions, (2) present the subcellular mechanisms underlying interactions of these two peptides, and (3) provide evidence that dysregulation of the cooperative action of Ang II and AVP significantly contributes to the development of disturbances in the regulation of blood pressure and the water-electrolyte balance in cardiovascular diseases.	Water	477-482	arginine vasopressin	Homo sapiens	91-94
29965451-10	2018	There is a slightly positive relationship between the reciprocal of the concentration of 1/rho(NO3-) and  15 N-NO3- during the wet season, indicating that mixing processes occurred in surface water.	Water	192-197	NBL1, DAN family BMP antagonist	Homo sapiens	95-98
29451291-1	2018	In this work, we demonstrate the synthesis and application of a novel CoII-based metal-organic framework {[Co2(Dcpp)(Bpe)0.5 (H2O)(mu2-H2O)] (Bpe)0.5}n (CoII-MOF, H4Dcpp = 4,5-bis(4"-carboxylphenyl)-phthalic acid, Bpe = 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection.	Water	126-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
29965451-10	2018	There is a slightly positive relationship between the reciprocal of the concentration of 1/rho(NO3-) and  15 N-NO3- during the wet season, indicating that mixing processes occurred in surface water.	Water	192-197	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
29965455-3	2018	The results show that overlying water and sediment interstitial water rho(TN) ranges from 1.10 to 6.90 mg L-1 and 6.19 to 32.57 mg L-1 respectively; indicating the nitrogen concentrations in the overlying and interstitial water of sediments have a certain variation along the process and vertically.	Water	32-37	immunoglobulin kappa variable 1-16	Homo sapiens	106-115
29965455-3	2018	The results show that overlying water and sediment interstitial water rho(TN) ranges from 1.10 to 6.90 mg L-1 and 6.19 to 32.57 mg L-1 respectively; indicating the nitrogen concentrations in the overlying and interstitial water of sediments have a certain variation along the process and vertically.	Water	64-69	immunoglobulin kappa variable 1-16	Homo sapiens	106-115
29965455-3	2018	The results show that overlying water and sediment interstitial water rho(TN) ranges from 1.10 to 6.90 mg L-1 and 6.19 to 32.57 mg L-1 respectively; indicating the nitrogen concentrations in the overlying and interstitial water of sediments have a certain variation along the process and vertically.	Water	64-69	immunoglobulin kappa variable 1-16	Homo sapiens	106-115
29965460-6	2018	Under dynamic conditions, the slight mixing of the water column near the sediment induced an increase in SOD and resulted in a gradual shift from first-order to zero-order DO uptake.	Water	51-56	superoxide dismutase 1	Homo sapiens	105-108
29559961-5	2018	Aminopeptidase and the trypsin-like activity were observed in all water bodies, indicating that a diverse set of peptidases is typical in freshwater.	Water	66-71	carboxypeptidase Q	Homo sapiens	0-14
29364677-9	2018	The comparison of the fog-collection behavior of the six samples showed that the superior fog-collection efficiency of surface patterns with extreme wetting contrast is due to the combination of water attraction and water repellency: the superhydrophilic spots act as drop accumulation areas, whereas the surrounding superhydrophobic areas allow a fast water transportation caused by gravity.	Water	195-200	zinc finger protein, FOG family member 1	Homo sapiens	22-25
29364677-9	2018	The comparison of the fog-collection behavior of the six samples showed that the superior fog-collection efficiency of surface patterns with extreme wetting contrast is due to the combination of water attraction and water repellency: the superhydrophilic spots act as drop accumulation areas, whereas the surrounding superhydrophobic areas allow a fast water transportation caused by gravity.	Water	195-200	zinc finger protein, FOG family member 1	Homo sapiens	90-93
29364677-9	2018	The comparison of the fog-collection behavior of the six samples showed that the superior fog-collection efficiency of surface patterns with extreme wetting contrast is due to the combination of water attraction and water repellency: the superhydrophilic spots act as drop accumulation areas, whereas the surrounding superhydrophobic areas allow a fast water transportation caused by gravity.	Water	216-221	zinc finger protein, FOG family member 1	Homo sapiens	22-25
29364677-9	2018	The comparison of the fog-collection behavior of the six samples showed that the superior fog-collection efficiency of surface patterns with extreme wetting contrast is due to the combination of water attraction and water repellency: the superhydrophilic spots act as drop accumulation areas, whereas the surrounding superhydrophobic areas allow a fast water transportation caused by gravity.	Water	216-221	zinc finger protein, FOG family member 1	Homo sapiens	90-93
29364677-9	2018	The comparison of the fog-collection behavior of the six samples showed that the superior fog-collection efficiency of surface patterns with extreme wetting contrast is due to the combination of water attraction and water repellency: the superhydrophilic spots act as drop accumulation areas, whereas the surrounding superhydrophobic areas allow a fast water transportation caused by gravity.	Water	216-221	zinc finger protein, FOG family member 1	Homo sapiens	22-25
29364677-9	2018	The comparison of the fog-collection behavior of the six samples showed that the superior fog-collection efficiency of surface patterns with extreme wetting contrast is due to the combination of water attraction and water repellency: the superhydrophilic spots act as drop accumulation areas, whereas the surrounding superhydrophobic areas allow a fast water transportation caused by gravity.	Water	216-221	zinc finger protein, FOG family member 1	Homo sapiens	90-93
29242169-1	2018	The effect of water-soluble pristine C60 fullerene nanoparticles (C60NPs) on receptor-operated cation channels formed by TRPC4/C6 proteins in ileal smooth muscle cells was investigated for the first time.	Water	14-19	transient receptor potential cation channel, subfamily C, member 4	Mus musculus	121-126
28355129-2	2018	Any sudden water pollution accident in the reservoir would threaten the water supply of the MRP.	Water	11-16	ATP binding cassette subfamily C member 1	Homo sapiens	92-95
28355129-2	2018	Any sudden water pollution accident in the reservoir would threaten the water supply of the MRP.	Water	72-77	ATP binding cassette subfamily C member 1	Homo sapiens	92-95
29366810-0	2018	Ruta graveolens water extract inhibits cell-cell network formation in human umbilical endothelial cells via MEK-ERK1/2 pathway.	Water	16-21	mitogen-activated protein kinase kinase 7	Homo sapiens	108-111
29366810-0	2018	Ruta graveolens water extract inhibits cell-cell network formation in human umbilical endothelial cells via MEK-ERK1/2 pathway.	Water	16-21	mitogen-activated protein kinase 3	Homo sapiens	112-118
29299557-4	2018	The results indicated that Abeta(11-42) peptide oligomers with peptide numbers larger than two were more likely to lead to lipid deformation and water channels, and the free energy of penetration into the membrane decreased with the increasing number of peptides.	Water	145-150	amyloid beta precursor protein	Homo sapiens	27-32
30966305-1	2018	Soy protein isolate (SPI) provides a potential alternative biopolymer source to fossil fuels, but improving the mechanical properties and water resistance of SPI composites remains a huge challenge.	Water	138-143	chromogranin A	Homo sapiens	21-24
30966305-1	2018	Soy protein isolate (SPI) provides a potential alternative biopolymer source to fossil fuels, but improving the mechanical properties and water resistance of SPI composites remains a huge challenge.	Water	138-143	chromogranin A	Homo sapiens	158-161
30966305-5	2018	Due to the synergistic interactions of pi-pi stacking and hydrogen bonding between the nanofillers and SPI chains, the tensile strength of SPI/G/CNT/NFC film significantly increased by 78.9% and the water vapor permeability decreased by 31.76% in comparison to neat SPI film.	Water	199-204	chromogranin A	Homo sapiens	103-106
30966305-5	2018	Due to the synergistic interactions of pi-pi stacking and hydrogen bonding between the nanofillers and SPI chains, the tensile strength of SPI/G/CNT/NFC film significantly increased by 78.9% and the water vapor permeability decreased by 31.76% in comparison to neat SPI film.	Water	199-204	chromogranin A	Homo sapiens	139-142
30966305-5	2018	Due to the synergistic interactions of pi-pi stacking and hydrogen bonding between the nanofillers and SPI chains, the tensile strength of SPI/G/CNT/NFC film significantly increased by 78.9% and the water vapor permeability decreased by 31.76% in comparison to neat SPI film.	Water	199-204	chromogranin A	Homo sapiens	139-142
29154217-4	2018	As for Al3+, its detection limit of 3.58x10-7M was significantly lower than the highest limit of Al3+ in drinking water recommended by the WHO (7.41muM), representing a rare example in reported fluorescent probe for Al3+ ion.	Water	114-119	latexin	Homo sapiens	148-151
29743860-3	2018	The treatment of pregnant rats with lead administrated in drinking water, from the 5th day of pregnancy until day 14 after delivery, induced an increased level of renal lipid peroxidation, protein carbonyl, hydrogen peroxide and advanced oxidation protein product, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in newborns.	Water	67-72	catalase	Rattus norvegicus	370-378
29504565-2	2018	The three crystal structures reported herein in the space groups P212121, I-4 and Pccn are defined solely by strong charge-assisted N-H...O hydrogen bonds and contain disordered guests (water and dimethylformamide) that vary in size, shape and degree of hydrophilicity.	Water	186-191	PPP1R2C family member C	Homo sapiens	74-77
29307720-1	2018	In this work, we examine the hypothesis about how trapped water molecules at the interface between triosephosphate isomerase (TIM) and either of two phosphorylated inhibitors, 2-phosphoglycolate (2PG) or phosphoglycolohydroxamate (PGH), can explain the anomalous highly negative binding heat capacities (DeltaCp,b) of both complexes, TIM-2PG and TIM-PGH.	Water	58-63	triosephosphate isomerase 1	Homo sapiens	99-124
29307720-1	2018	In this work, we examine the hypothesis about how trapped water molecules at the interface between triosephosphate isomerase (TIM) and either of two phosphorylated inhibitors, 2-phosphoglycolate (2PG) or phosphoglycolohydroxamate (PGH), can explain the anomalous highly negative binding heat capacities (DeltaCp,b) of both complexes, TIM-2PG and TIM-PGH.	Water	58-63	triosephosphate isomerase 1	Homo sapiens	126-129
29307720-1	2018	In this work, we examine the hypothesis about how trapped water molecules at the interface between triosephosphate isomerase (TIM) and either of two phosphorylated inhibitors, 2-phosphoglycolate (2PG) or phosphoglycolohydroxamate (PGH), can explain the anomalous highly negative binding heat capacities (DeltaCp,b) of both complexes, TIM-2PG and TIM-PGH.	Water	58-63	triosephosphate isomerase 1	Homo sapiens	334-337
29307720-1	2018	In this work, we examine the hypothesis about how trapped water molecules at the interface between triosephosphate isomerase (TIM) and either of two phosphorylated inhibitors, 2-phosphoglycolate (2PG) or phosphoglycolohydroxamate (PGH), can explain the anomalous highly negative binding heat capacities (DeltaCp,b) of both complexes, TIM-2PG and TIM-PGH.	Water	58-63	triosephosphate isomerase 1	Homo sapiens	334-337
29307720-8	2018	Our results strongly suggest that some water molecules became immobilized when the TIM-inhibitor complexes were formed.	Water	39-44	triosephosphate isomerase 1	Homo sapiens	83-86
29307720-9	2018	A computational analysis of the hydration state of the binding site of TIM in both its free state and its complexed form with 2PG or PGH, based on molecular dynamics (MD) simulations in explicit solvent, showed that the binding site effectively immobilized additional water molecules after binding these inhibitors.	Water	268-273	triosephosphate isomerase 1	Homo sapiens	71-74
29245148-14	2018	NO3- of river water in the upper reaches are come from nitrogen in precipitation and soil organic N. River water in the lower reaches is polluted by a mixture of soil organic N and fertilizers.	Water	14-19	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
29245148-14	2018	NO3- of river water in the upper reaches are come from nitrogen in precipitation and soil organic N. River water in the lower reaches is polluted by a mixture of soil organic N and fertilizers.	Water	107-112	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
29560463-5	2018	A compelling hypothesis for the evolution of a heterodimeric Type I reaction centre is that the gene duplication that allowed the divergence of PsaA and PsaB was an adaptation to incorporate photoprotective mechanisms against the formation of reactive oxygen species, therefore occurring after the origin of water oxidation to oxygen.	Water	308-313	fatty acid amide hydrolase	Homo sapiens	153-157
28967192-1	2018	The main determinants for the maintenance of water homeostasis are the hormone arginine vasopressin (AVP) and thirst.	Water	45-50	arginine vasopressin	Homo sapiens	88-99
29433230-2	2018	It was hypothesized that the physical state and solid content in the inner phases of water-in-oil-in-water (W1/O/W2) emulsions may affect the overall stability and the release behavior of bioactives during in vitro digestion.	Water	85-90	flavonoid 3', 5'-hydroxylase	Glycine max	108-115
29433230-2	2018	It was hypothesized that the physical state and solid content in the inner phases of water-in-oil-in-water (W1/O/W2) emulsions may affect the overall stability and the release behavior of bioactives during in vitro digestion.	Water	101-106	flavonoid 3', 5'-hydroxylase	Glycine max	108-115
29393397-2	2018	The aim of this study was to validate the use of oxygen nanobubble water to overcome resistance to radiation in cancer cell lines via the suppression of the hypoxia-inducible factor 1-alpha (HIF-1alpha) subunit.	Water	67-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-189
29393397-2	2018	The aim of this study was to validate the use of oxygen nanobubble water to overcome resistance to radiation in cancer cell lines via the suppression of the hypoxia-inducible factor 1-alpha (HIF-1alpha) subunit.	Water	67-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	191-201
29393397-11	2018	This newly created single-nanometer range oxygen nanobubble water, without any additives, may thus prove to be a promising agent which may be used to overcome the hypoxia-induced resistance of cancer cells to radiation via the suppression of HIF-1alpha.	Water	60-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	242-252
28967192-1	2018	The main determinants for the maintenance of water homeostasis are the hormone arginine vasopressin (AVP) and thirst.	Water	45-50	arginine vasopressin	Homo sapiens	101-104
28967192-7	2018	The direct measurement of AVP during the water deprivation test, which was reported in the 1980s, has not been widely adopted due to availability, assay issues and diagnostic performance.	Water	41-46	arginine vasopressin	Homo sapiens	26-29
29237740-7	2018	Consistent with these effects, Grhl2-deficient mice had diabetes insipidus, produced dilute urine, and failed to adequately concentrate their urine after water restriction, resulting in susceptibility to prerenal azotemia.	Water	154-159	grainyhead like transcription factor 2	Mus musculus	31-36
29604711-1	2018	A full-field perturbation approach is modified for an ice-covered ocean and applied to estimating narrowband long-range reverberation caused by roughness of the ice-water interface.	Water	165-170	carboxylesterase 2	Homo sapiens	161-164
29280103-3	2018	The results indicate that the total PFC concentration in raw water is 261.51 ng L-1 and that perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are the predominant pollutants.	Water	61-66	immunoglobulin kappa variable 1-16	Homo sapiens	80-83
29222980-5	2018	DOX more strongly bound to HSA than silica also affects structure of interfacial water layers that depends on dispersion media because chloroform as immiscible with water changes the water organization to enlarge water structures.	Water	81-86	albumin	Homo sapiens	27-30
29413582-3	2018	After a simple step of solid-phase extraction, the chromatographic separation of human insulin was achieved by using InertSustain Bio C18 column with a mobile phase of acetonitrile containing 1% formic acid (A)-water containing 1% formic acid (B).	Water	211-216	insulin	Homo sapiens	87-94
29222980-5	2018	DOX more strongly bound to HSA than silica also affects structure of interfacial water layers that depends on dispersion media because chloroform as immiscible with water changes the water organization to enlarge water structures.	Water	165-170	albumin	Homo sapiens	27-30
29222980-5	2018	DOX more strongly bound to HSA than silica also affects structure of interfacial water layers that depends on dispersion media because chloroform as immiscible with water changes the water organization to enlarge water structures.	Water	165-170	albumin	Homo sapiens	27-30
29222980-5	2018	DOX more strongly bound to HSA than silica also affects structure of interfacial water layers that depends on dispersion media because chloroform as immiscible with water changes the water organization to enlarge water structures.	Water	165-170	albumin	Homo sapiens	27-30
29295820-4	2018	C57BL/6J Diet1-/- mice had elevated bile acid levels, reduced Fgf15 expression, and increased gastrointestinal motility and intestinal luminal water content, which are symptoms of bile acid diarrhea (BAD) in humans.	Water	143-148	Malrd1	Mus musculus	9-14
29251736-0	2018	PGE2 EP1 receptor inhibits vasopressin-dependent water reabsorption and sodium transport in mouse collecting duct.	Water	49-54	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	5-8
29232050-0	2018	Affinity extraction of emerging contaminants from water based on bovine serum albumin as a binding agent.	Water	50-55	albumin	Homo sapiens	72-85
29232050-1	2018	Affinity sorbents using bovine serum albumin as a binding agent were developed and tested for the extraction of environmental contaminants from water.	Water	144-149	albumin	Homo sapiens	37-44
29497866-1	2018	The interactions of bovine serum albumin (BSA) with urea/water were investigated by computer simulation.	Water	57-62	albumin	Homo sapiens	27-40
29413116-10	2018	LPS-stimulated PMs from aluminum-intoxicated animals exhibited low phagocytic activity and release of TNF-alpha, this was significantly improved by silicon-rich water intake.	Water	161-166	tumor necrosis factor	Rattus norvegicus	102-111
29413116-13	2018	The presence of high levels of the natural aluminum antagonist silicon in the drinking water restored IL-10 and TNF-alpha PM secretion, preventing prolonged inflammation.	Water	87-92	tumor necrosis factor	Rattus norvegicus	112-121
29251736-11	2018	Taken together, the data suggest that EP1 regulates renal aquaporins and sodium transporters, attenuates AVP-water transport and inhibits sodium transport in the mouse collecting duct, which is mediated by both ENaC and pendrin-dependent pathways.	Water	109-114	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	38-41
29365267-3	2018	We conclude that the formation yield of NO3 , just after the 7 ps electron pulse, is due to the direct effect and to the ultrafast electron transfer reaction between NO3- and the water cation radical, H2O +.	Water	179-184	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
29044986-2	2018	To overcome the poor water solubility of PL, there is a need to develop a novel water-soluble formulation in which PL is non-covalently bound to human serum albumin (HSA).	Water	80-85	albumin	Homo sapiens	151-164
29281082-4	2018	Under moderate water deficit, the AOX amount was an important determinant of the rate of both mitochondrial respiration in the light and net photosynthetic CO2 assimilation (A) at the growth irradiance.	Water	15-20	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	34-37
29281082-5	2018	In particular, AOX respiration was necessary to maintain optimal proton and electron fluxes at the chloroplast thylakoid membrane, which in turn prevented a water-deficit-induced biochemical limitation of photosynthesis.	Water	157-162	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	15-18
28968061-7	2018	As anticipated, IT administration of AGRP caused weight gain, increase of food/water intake, and increase respiratory exchange ratio (RER).	Water	79-84	agouti related neuropeptide	Mus musculus	37-41
29309055-1	2018	Most G-protein-coupled receptors (GPCRs) are stabilized in common in the inactive state by the formation of the sodium ion-centered water cluster with the conserved Asp2.50 inside the seven-transmembrane domain.	Water	132-137	beta-secretase 1	Homo sapiens	165-169
29100694-6	2018	Tap water samples from Canada showed noteworthy differences depending on their source; for instance,  29PFASwas significantly greater in those produced from the Great Lakes/St.	Water	4-9	SEC14 like lipid binding 2	Homo sapiens	0-3
29400057-10	2018	Additionally, when used as an overall water-splitting catalyst, P-Co-Ni-S/NF can provide a 10 mA cm-2 current density at a given cell voltage of 1.60 V in 1 M KOH, which is competitive to the best-known electrocatalysts, with high long-term stability.	Water	38-43	solute carrier family 5 member 5	Homo sapiens	69-73
29256565-2	2018	The final as-synthesized product [Mg0.69Al0.31(OH)2] (phytateNa6)0.05 (NO3)0.01 mH2O (phytate-LDH) has highly selective adsorption ability for some metal ions and can be used to enrich rare earth metal ions in mixed solution, such as Pr3+ and Ce3+ from a mixed solution of them with Pb2+ and Co2+.	Water	47-51	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
29251932-1	2018	Cystic fibrosis (CF) is a multiorgan disease of the lungs, sinuses, pancreas, and gastrointestinal tract that is caused by a dysfunction or deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, an epithelial anion channel that regulates salt and water balance in the tissues in which it is expressed.	Water	278-283	CF transmembrane conductance regulator	Homo sapiens	158-209
29251932-1	2018	Cystic fibrosis (CF) is a multiorgan disease of the lungs, sinuses, pancreas, and gastrointestinal tract that is caused by a dysfunction or deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, an epithelial anion channel that regulates salt and water balance in the tissues in which it is expressed.	Water	278-283	CF transmembrane conductance regulator	Homo sapiens	211-215
29365267-3	2018	We conclude that the formation yield of NO3 , just after the 7 ps electron pulse, is due to the direct effect and to the ultrafast electron transfer reaction between NO3- and the water cation radical, H2O +.	Water	179-184	NBL1, DAN family BMP antagonist	Homo sapiens	166-169
29365267-3	2018	We conclude that the formation yield of NO3 , just after the 7 ps electron pulse, is due to the direct effect and to the ultrafast electron transfer reaction between NO3- and the water cation radical, H2O +.	Water	201-204	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
29365267-3	2018	We conclude that the formation yield of NO3 , just after the 7 ps electron pulse, is due to the direct effect and to the ultrafast electron transfer reaction between NO3- and the water cation radical, H2O +.	Water	201-204	NBL1, DAN family BMP antagonist	Homo sapiens	166-169
29412653-7	2018	Amide pendents deprotonate at high pH (&gt;8), and the water ligands of the Co(II) complexes are not deprotonated at neutral pH.	Water	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
29594488-8	2018	Under optimal conditions, the limits of detection range from 70 to 800 ng L-1, with linear responses from 0.1-500 mug L-1 (water samples), 0.6-500 mug L-1 (spiked urine), and 0.9-500 mug L-1 (spiked plasma).	Water	123-128	immunoglobulin kappa variable 1-16	Homo sapiens	74-77
29412653-0	2018	Inner-Sphere and Outer-Sphere Water Interactions in Co(II) paraCEST Agents.	Water	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
29412653-2	2018	The first examples of Co(II) paraCEST agents with bound water ligands are presented here.	Water	56-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
29251308-5	2018	In vitro assays in combination with various sample enrichment methods have been used with limits of detection as low as 0.0027 ng L-1 in water, and 0.0026 ng g-1 in sediments for estrogenicity, 0.1 ng L-1 in water, and 0.5 ng g-1 in sediments for androgenicity, and 5 ng L-1 in water for progestogenicity expressed as equivalent concentrations of standard reference compounds of 17beta-estradiol, dihydrotestosterone and progesterone, respectively.	Water	137-142	L1 cell adhesion molecule	Homo sapiens	130-133
29395519-9	2018	The water-in-oil emulsion modulated the expression of TNF-alpha; the xanthan gum modulated IL-4, IL-10, and IL-12; and alum hydroxide modulated IFN-gamma, TNF-alpha, IL-4, IL-10, and IL-12.	Water	4-9	tumor necrosis factor	Mus musculus	54-63
29376536-1	2018	Treatment of Lambda-fac-[Co(d-pen-N,S)3]3- (d-H2pen = d-penicillamine) with Cu+ in water gave a stable CoCu complex, LambdaLambda-[Co2Cu3(d-pen)6]3- ([1]3-), having three thiolato-copper(i)-thiolato moieties that bridge two cobalt(iii) centres.	Water	83-88	FA complementation group C	Homo sapiens	20-23
29454339-3	2018	AQP8 conducts water, ammonia, urea, glycerol and H2O2 through various membranes of animal cells.	Water	14-19	aquaporin 8	Homo sapiens	0-4
29279111-3	2018	These functional adsorbents were used for removal of Pb(II) and Cd(II) as single and binary competitive mixtures from water.	Water	118-123	submaxillary gland androgen regulated protein 3B	Homo sapiens	53-70
29279111-0	2018	Chitosan based nano composite adsorbent-Synthesis, characterization and application for adsorption of binary mixtures of Pb(II) and Cd(II) from water.	Water	144-149	submaxillary gland androgen regulated protein 3B	Homo sapiens	121-138
29422070-3	2018	The most important hormone for the regulation of water homeostasis is arginine vasopressin, and copeptin, the C-terminal portion of the precursor peptide of arginine vasopressin, might be a reliable new parameter with which to assess the underlying cause of hypernatraemia.	Water	49-54	arginine vasopressin	Homo sapiens	79-90
29045930-10	2018	The spiked experiments for tap water show good recoveries from 87.4% to 110.5% with a relative standard deviation of less than 4.22%.	Water	31-36	SEC14 like lipid binding 2	Homo sapiens	27-30
29442182-0	2018	Structure and dynamics of the peptide strand KRFK from the thrombospondin TSP-1 in water.	Water	83-88	thrombospondin 1	Homo sapiens	74-79
29472987-16	2018	However, family history may not always be informative due to the variable nature of the condition or if the proband has a de novo pathogenic variant.A water load test with measurement of AVP may be informative in distinguishing NSIAD from SIADH.	Water	151-156	arginine vasopressin	Homo sapiens	187-190
29134712-8	2018	This is a typical case of degradation where co-solvents acetonitrile-water (50:50, v/v) and methanol-water (50:50, v/v) react with CAN under acid hydrolytic conditions leading to the formation of pseudo-DPs, DP3 and DP4, respectively.	Water	69-74	transcription factor Dp family member 3	Homo sapiens	216-219
29134712-8	2018	This is a typical case of degradation where co-solvents acetonitrile-water (50:50, v/v) and methanol-water (50:50, v/v) react with CAN under acid hydrolytic conditions leading to the formation of pseudo-DPs, DP3 and DP4, respectively.	Water	101-106	transcription factor Dp family member 3	Homo sapiens	216-219
29367989-0	2018	Synthesis and application of a water-soluble phosphorescent iridium complex as turn-on sensing material for human serum albumin.	Water	31-36	albumin	Homo sapiens	114-127
29422070-3	2018	The most important hormone for the regulation of water homeostasis is arginine vasopressin, and copeptin, the C-terminal portion of the precursor peptide of arginine vasopressin, might be a reliable new parameter with which to assess the underlying cause of hypernatraemia.	Water	49-54	arginine vasopressin	Homo sapiens	96-104
29964827-3	2018	The results showed that 17 VOCs and SVOCs in the surface water samples of 4 monitoring sections were detected, in a concentration range of 0.01-1.21 mug L-1, which is a low pollution level.	Water	57-62	immunoglobulin kappa variable 1-16	Homo sapiens	153-156
29341613-7	2018	We combine molecular dynamics simulations, quantum calculations, and X-ray analyses to discover that a team of approximately 10 water molecules confined inside a barrel-shaped nanocavity at the center of insulin hexamer is one of the major causes that account for the unusual stability of the biomolecular assembly.	Water	128-133	insulin	Homo sapiens	204-211
29205563-4	2018	Exceptionally, by addition of 1 % NaF to a suspension of the foldamer in H2 O/THF (95:5), the fluorescence quenching efficiency by TNT vapor significantly increased from about 20 % to more than 90 %.	Water	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
29467744-2	2018	In this work, we investigated the diversity of cultivable bacteria and their ECEs and the potential activities of aminopeptidase in the water column at eight different depths of the New Britain Trench.	Water	136-141	carboxypeptidase Q	Homo sapiens	114-128
29467744-7	2018	Meanwhile, the Vmax and Km of aminopeptidase exhibited a maximum in the surface water and low values in the deep bathy- and abyssopelagic water, indicating lower rates of hydrolysis and higher substrate affinity in the deeper waters.	Water	80-85	carboxypeptidase Q	Homo sapiens	30-44
29467744-7	2018	Meanwhile, the Vmax and Km of aminopeptidase exhibited a maximum in the surface water and low values in the deep bathy- and abyssopelagic water, indicating lower rates of hydrolysis and higher substrate affinity in the deeper waters.	Water	138-143	carboxypeptidase Q	Homo sapiens	30-44
29183834-5	2018	We attached hydrophobic C18 chains to water-soluble fluorescent probes for pH and chloride.	Water	38-43	Bardet-Biedl syndrome 9	Homo sapiens	24-27
29236341-2	2018	These peaks are due to the J-coupling between the water protons and the 17 O nucleus, which has spin-5/2.	Water	50-55	spindlin family member 2A	Homo sapiens	96-104
28915469-2	2018	To circumvent the detracting feature, two novel water-soluble amino acid modified curcumin derivatives (MLC and DLC) have been synthesized through the condensation reaction between curcumin and Nalpha-Fmoc-Nepsilon-Boc-l-lysine.	Water	48-53	modulator of VRAC current 1	Homo sapiens	104-107
28918219-1	2018	The optical properties of a novel chemosensor for cyanide anions based on a symmetric bis(salamo)-type ligand (H3L) were investigated by UV-Vis and fluorescence spectroscopy in MeOH/H2O (1:1 v/v) solution.	Water	182-185	H3 clustered histone 2	Homo sapiens	111-114
29030247-2	2018	To date, little is known about the effect of gut microbiota generated lipopolysaccharide (LPS) on intestinal absorption of water-soluble vitamins.	Water	123-128	toll-like receptor 4	Mus musculus	90-93
27878482-0	2018	An in-vitro approach for water quality determination: activation of NF-kappaB as marker for cancer-related stress responses induced by anthropogenic pollutants of drinking water.	Water	25-30	nuclear factor kappa B subunit 1	Homo sapiens	68-77
29186291-0	2018	Sex Differences in the Behavioral Desensitization of Water Intake Observed After Repeated Central Injections of Angiotensin II.	Water	53-58	angiotensinogen	Rattus norvegicus	112-126
29186291-5	2018	As expected, when male rats were pretreated with AngII, they drank less water after a test injection of AngII than did rats pretreated with vehicle.	Water	72-77	angiotensinogen	Rattus norvegicus	49-54
29186291-5	2018	As expected, when male rats were pretreated with AngII, they drank less water after a test injection of AngII than did rats pretreated with vehicle.	Water	72-77	angiotensinogen	Rattus norvegicus	104-109
28942694-2	2018	Aquaporin 9 may transport not only water but also small molecules, such as glycerol, monocarboxylates, purines and pyrimidines.	Water	35-40	aquaporin 9	Homo sapiens	0-11
29218575-3	2018	The water with NaCl concentration of 66.7 mg L-1 had the highest leaching ability, the hazardous materials were leached after only approximately 50 days (average time, with a standard deviation of 4.1), while less than 100 days were needed in the others.	Water	4-9	immunoglobulin kappa variable 1-16	Homo sapiens	45-48
29389871-10	2018	The peak intensities at 1285 and 1322 cm-1 were used to estimate the tetracycline concentrations in water and milk with correlation coefficients of 0.92 for water and 0.88 for milk.	Water	157-162	Weaning weight-maternal milk	Bos taurus	110-114
28964940-1	2018	The adsorption of cytochrome c in water onto organic and carbon xerogels with narrow pore size distributions has been studied by carrying out transient and equilibrium batch adsorption experiments.	Water	34-39	cytochrome c, somatic	Homo sapiens	18-30
29031147-1	2018	Novel hydrated zirconium oxide (ZrO(OH)2) coated carbon nanotubes (CNTs) were prepared via a filtration-steam hydrolysis method, and were used to remove As(III) and As(V) from drinking water.	Water	185-190	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	165-170
29600629-12	2018	So the pathway of AVP-V2R-AQP2 may be one of the mechanism for which Zhenwu Tang regulate balance of water transportation.	Water	101-106	arginine vasopressin receptor 2	Rattus norvegicus	22-25
29136825-3	2018	The pasta dough formed by mixing flour and water is extruded through an extrusion die to mould the appropriate pasta form and is dried to obtain a stable product.	Water	43-48	solute carrier family 45 member 1	Homo sapiens	4-9
29136825-3	2018	The pasta dough formed by mixing flour and water is extruded through an extrusion die to mould the appropriate pasta form and is dried to obtain a stable product.	Water	43-48	solute carrier family 45 member 1	Homo sapiens	111-116
29309165-0	2018	Redox-Active Ligand Assisted Multielectron Catalysis: A Case of CoIII Complex as Water Oxidation Catalyst.	Water	81-86	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	64-69
29136915-2	2018	Water-soluble CdTe quantum dots (QDs) were selected as the fluorescent label and were linked covalently to anti-hFABP antibodies.	Water	0-5	fatty acid binding protein 3	Homo sapiens	112-117
29381136-2	2018	The conserved mitochondrial-encoded COX1- and COX2-subunits are the heme- and copper-center containing core subunits that catalyze water formation.	Water	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
29309165-3	2018	In this article, the electrocatalytic oxidation of water by Na[(L4-)CoIII], where L is a substituted tetraamido macrocyclic ligand, was investigated in aqueous solution (pH 7.0).	Water	51-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	68-73
29309165-4	2018	We found that Na[(L4-)CoIII] is a stable and efficient homogeneous catalyst for electrocatalytic water oxidation with 380 mV onset overpotential in 0.1 M phosphate buffer (pH 7.0).	Water	97-102	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	22-27
29309165-6	2018	In this cycle, Na[(L4-)CoIII] was first oxidized to [(L2-)CoIIIOH] via a ligand-centered proton-coupled electron transfer process in the presence of water.	Water	149-154	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	23-28
29404208-7	2018	Environmental factors (especially turbidity and nitrite) exhibited significant influences on bacterial beta-diversity in surface water (at 0 m sampling depth), while community similarity in bottom water (at 2-3 m above sediment) was mainly determined by depth.	Water	129-134	INTS3 and NABP interacting protein	Homo sapiens	79-81
29390798-0	2018	Deciphering complex dynamics of water counteraction around secondary structural elements of allosteric protein complex: Case study of SAP-SLAM system in signal transduction cascade.	Water	32-37	SH2 domain containing 1A	Homo sapiens	134-137
29390798-0	2018	Deciphering complex dynamics of water counteraction around secondary structural elements of allosteric protein complex: Case study of SAP-SLAM system in signal transduction cascade.	Water	32-37	signaling lymphocytic activation molecule family member 1	Homo sapiens	138-142
29390798-5	2018	We observed that water dynamics around different secondary structural elements became highly affected as well as nicely correlated with the SLAM-peptide induced change in structural rigidity obtained by thermodynamic quantification.	Water	17-22	signaling lymphocytic activation molecule family member 1	Homo sapiens	140-144
29390798-8	2018	Most importantly, we have quantified enhanced restriction in water dynamics around the second Fyn-binding site of the SAP due to SAP-SLAM complexation, even prior to the presence of Fyn.	Water	61-66	SH2 domain containing 1A	Homo sapiens	118-121
29594681-8	2018	It was applied to the determination of Pb(II) in (spiked) water and soil samples and gave good results.	Water	58-63	submaxillary gland androgen regulated protein 3B	Homo sapiens	39-45
29404208-7	2018	Environmental factors (especially turbidity and nitrite) exhibited significant influences on bacterial beta-diversity in surface water (at 0 m sampling depth), while community similarity in bottom water (at 2-3 m above sediment) was mainly determined by depth.	Water	129-134	INTS3 and NABP interacting protein	Homo sapiens	118-120
29390798-8	2018	Most importantly, we have quantified enhanced restriction in water dynamics around the second Fyn-binding site of the SAP due to SAP-SLAM complexation, even prior to the presence of Fyn.	Water	61-66	SH2 domain containing 1A	Homo sapiens	129-132
29404208-8	2018	In both surface and bottom water, we found bacterial community similarity and the number of OTUs shared between every two sites decreased with increasing geographic distance.	Water	27-32	INTS3 and NABP interacting protein	Homo sapiens	0-2
29390798-8	2018	Most importantly, we have quantified enhanced restriction in water dynamics around the second Fyn-binding site of the SAP due to SAP-SLAM complexation, even prior to the presence of Fyn.	Water	61-66	signaling lymphocytic activation molecule family member 1	Homo sapiens	133-137
29308488-2	2018	Dibenzo-7-phosphanorbornadiene derivatives (XPA) are introduced as versatile precursors to amorphous metal phosphide electrocatalysts for proton reduction in acidic water.	Water	165-170	XPA, DNA damage recognition and repair factor	Homo sapiens	44-47
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	77-82	signaling lymphocytic activation molecule family member 1	Homo sapiens	48-52
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	77-82	SH2 domain containing 1A	Homo sapiens	210-213
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	110-115	signaling lymphocytic activation molecule family member 1	Homo sapiens	48-52
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	110-115	SH2 domain containing 1A	Homo sapiens	210-213
29390798-10	2018	Finally, SLAM induced water counteraction around the second binding site of the SAP sheds light on the allosteric property of the SAP, which becomes an integral part of the underlying signal transduction mechanism.	Water	22-27	signaling lymphocytic activation molecule family member 1	Homo sapiens	9-13
29390798-10	2018	Finally, SLAM induced water counteraction around the second binding site of the SAP sheds light on the allosteric property of the SAP, which becomes an integral part of the underlying signal transduction mechanism.	Water	22-27	SH2 domain containing 1A	Homo sapiens	80-83
29390798-10	2018	Finally, SLAM induced water counteraction around the second binding site of the SAP sheds light on the allosteric property of the SAP, which becomes an integral part of the underlying signal transduction mechanism.	Water	22-27	SH2 domain containing 1A	Homo sapiens	130-133
29364148-2	2018	The selective DYRK1A inhibitor 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid (KuFal194), a large, flat and lipophilic molecule, suffers from poor water solubility, limiting its use as chemical probe in cellular assays and animal models.	Water	153-158	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	14-20
29120646-10	2018	Notably, the dissipation energy also dropped during the binding process between CRP and PC, indicating the release of water molecules from the PC groups during CRP adsorption.	Water	118-123	C-reactive protein	Homo sapiens	80-83
29120646-10	2018	Notably, the dissipation energy also dropped during the binding process between CRP and PC, indicating the release of water molecules from the PC groups during CRP adsorption.	Water	118-123	C-reactive protein	Homo sapiens	160-163
27196114-2	2018	Washing with tap water only marginally reduces microorganisms attached to produce surfaces.	Water	17-22	SEC14 like lipid binding 2	Homo sapiens	13-16
29120077-5	2018	The double C18 aliphatic chain on one side, Gd-1,4,7,10-tetraazacyclododecane-1-4-7-triacetic acid (Gd-DO3A) with access to bulk water in the center and 2 kDa PEG on the hydrophilic side gave the amphiphilic properties required for the core-shell nanomicellar architecture.	Water	129-134	Bardet-Biedl syndrome 9	Homo sapiens	11-14
29214722-3	2018	The best water oxidation activity is obtained with cobalt hydroxide carbonate templated t-CoII -CoIII with an overpotential as low as 240 mV to reach a current density of 10 mA cm-2 .	Water	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
29214722-3	2018	The best water oxidation activity is obtained with cobalt hydroxide carbonate templated t-CoII -CoIII with an overpotential as low as 240 mV to reach a current density of 10 mA cm-2 .	Water	9-14	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	96-101
29367634-1	2018	The guanylate cyclase C (GC-C) receptor regulates electrolyte and water secretion into the gut following activation by the E. coli enterotoxin STa, or by weaker endogenous agonists guanylin and uroguanylin.	Water	66-71	guanylate cyclase 2c	Mus musculus	25-29
29291441-1	2018	A new water-soluble conjugate, consisting of a chlorin-based photosensitizing part, and a 4-arylaminoquinazoline moiety with high potential affinity to an epidermal growth factor receptors (EGFR) and vascular endothelial growth factor receptors (VEGFR), suitable for photodynamic therapy (PDT), was synthesized starting from methylpheophorbide-a in seven steps.	Water	6-11	epidermal growth factor receptor	Homo sapiens	155-188
29291441-1	2018	A new water-soluble conjugate, consisting of a chlorin-based photosensitizing part, and a 4-arylaminoquinazoline moiety with high potential affinity to an epidermal growth factor receptors (EGFR) and vascular endothelial growth factor receptors (VEGFR), suitable for photodynamic therapy (PDT), was synthesized starting from methylpheophorbide-a in seven steps.	Water	6-11	epidermal growth factor receptor	Homo sapiens	190-194
29101877-9	2018	Finally, C18-Mica-4 was applied successfully to the removal of the target compounds from influent and effluent wastewater, surface water and tap water samples.	Water	116-121	Bardet-Biedl syndrome 9	Homo sapiens	9-12
29231705-8	2018	The weight of water increased with the increasing of the thrombin concentration in the range of 0 to 100 nM with a detection limit of 2.8 nM.	Water	14-19	coagulation factor II, thrombin	Homo sapiens	57-65
29239453-5	2018	The experimental results also showed that with the addition of aluminium chloride at 100 mg L-1, the water separation was about 70% after 20 min.	Water	101-106	immunoglobulin kappa variable 1-16	Homo sapiens	92-95
29101877-9	2018	Finally, C18-Mica-4 was applied successfully to the removal of the target compounds from influent and effluent wastewater, surface water and tap water samples.	Water	131-136	Bardet-Biedl syndrome 9	Homo sapiens	9-12
29375306-4	2017	Brain injury was induced by autologous arterial blood (60 muL) injection into rat brains, and data show that activation of SIRT1 with SRT1720 (5 mg/kg) restored nuclear SIRT1, deacetylation of PGC-1alpha, and mitochondrial biogenesis and decreased mortality, behavioral deficits, and brain water content without significant changes in phosphorylated AMP-activated protein kinase (pAMPK) induced by ICH.	Water	290-295	sirtuin 1	Rattus norvegicus	123-128
28985278-8	2018	DBP was lower following WATER compared to CONTROL: 1.2 +- 0.3 mm Hg over 21 hours (P = 0.043); 0.9 +- 0.6 mm Hg over awake hours (P = 0.101); and 1.4 +- 0.9 mm Hg over sleep hours (P = 0.039).	Water	24-29	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
29321556-6	2018	The SPC/E water model is the best three-point parameterisation of water for this purpose.	Water	10-15	proline rich protein gene cluster	Homo sapiens	4-7
29321556-6	2018	The SPC/E water model is the best three-point parameterisation of water for this purpose.	Water	66-71	proline rich protein gene cluster	Homo sapiens	4-7
29311539-1	2018	BACKGROUND Tolvaptan, an antagonist of the vasopressin V2 receptor is a novel oral diuretic that promotes water excretion selectively.	Water	106-111	arginine vasopressin receptor 2	Homo sapiens	43-66
29375306-8	2017	Treatment with SIRT1 siRNA increased mortality, behavioral deficits, brain water content, mitochondrial dysfunction, and neurocyte apoptosis after ICH.	Water	75-80	sirtuin 1	Rattus norvegicus	15-20
29306291-0	2018	Dynamic exit-channel pathways of the microsolvated HOO-(H2O) + CH3Cl SN2 reaction: Reaction mechanisms at the atomic level from direct chemical dynamics simulations.	Water	56-59	solute carrier family 38 member 5	Homo sapiens	69-72
29965675-4	2018	Fortunately, it can meet the water standards by increasing the amount of dosed phosphate to 30 mug L-1 or increasing the height of the filter layer.	Water	29-34	immunoglobulin kappa variable 1-16	Homo sapiens	99-102
29306291-1	2018	Microsolvated bimolecular nucleophilic substitution (SN2) reaction of monohydrated hydrogen peroxide anion [HOO-(H2O)] with methyl chloride (CH3Cl) has been investigated with direct chemical dynamics simulations at the M06-2X/6-31+G(d,p) level of theory.	Water	113-116	solute carrier family 38 member 5	Homo sapiens	53-56
29965683-5	2018	The Freundlich isotherm showed that activated carbon had better adsorption properties for NH4+-N, TP, and permanganate index in water.When the disk speed was 3 r min-1, the removal efficiency was the best, and the removal rates of NH4+-N, TP and permanganate index were the best at 86.05%, 81.28%, and 77.09%, respectively.	Water	128-133	CD59 molecule (CD59 blood group)	Homo sapiens	162-167
29306291-9	2018	Compared with the HOO- + CH3Cl SN2 reaction, indirect dynamic reaction mechanisms are enhanced by microsolvation for the HOO-(H2O) + CH3Cl SN2 reaction.	Water	126-129	solute carrier family 38 member 5	Homo sapiens	31-34
29306291-9	2018	Compared with the HOO- + CH3Cl SN2 reaction, indirect dynamic reaction mechanisms are enhanced by microsolvation for the HOO-(H2O) + CH3Cl SN2 reaction.	Water	126-129	solute carrier family 38 member 5	Homo sapiens	139-142
29306291-10	2018	On the basis of our simulations, further crossed molecular beam imaging experiments are highly suggested for the SN2 reactions of HOO- + CH3Cl and HOO-(H2O) + CH3Cl.	Water	152-155	solute carrier family 38 member 5	Homo sapiens	113-116
29301341-7	2018	Subsequently, we found AQP1 and AQP3 to be the most predominant AQPs accounting for water and glycerol fluxes, respectively, in the healthy endothelium.	Water	84-89	aquaporin 1 (Colton blood group)	Homo sapiens	23-27
28806557-6	2018	At the same time, the efficient detection of the PCB 77 by our colorimetric sensor in the complex environmental water samples was realized, which shows a good application prospect.	Water	112-117	pyruvate carboxylase	Homo sapiens	49-52
29354070-2	2017	Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel.	Water	51-56	carbonic anhydrase 2	Mus musculus	34-38
29354070-2	2017	Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel.	Water	74-79	carbonic anhydrase 2	Mus musculus	34-38
29354070-8	2017	Urinary concentration remained reduced in CAII-deficient mice relative to wild-type animals even after water deprivation.	Water	103-108	carbonic anhydrase 2	Mus musculus	42-46
29354070-11	2017	CAII associates with and increases water flux through aquaporin-1.	Water	35-40	carbonic anhydrase 2	Mus musculus	0-4
28755052-7	2018	A combination of more representative in vivo hydrodynamics and ease of maintaining sink conditions yields the USP 4 flow-through cell method a more suitable in vitro release method for nanosuspension-based LAP formulations of poorly water-soluble compounds, such as compounds A and B.	Water	233-238	ubiquitin specific peptidase 4	Homo sapiens	110-115
29231739-11	2018	Our results demonstrate several ways in which nanoscale hybrid vesicles can and should be optimized for PLA2-triggered release of water-soluble compounds.	Water	130-135	phospholipase A2 group IB	Homo sapiens	104-108
29146716-12	2018	In addition, p16-positive patients with high mean intracellular water molecule lifetime and high volume transfer constant demonstrated a trend toward the longest overall survival.	Water	64-69	cyclin dependent kinase inhibitor 2A	Homo sapiens	13-16
29477225-3	2018	Moreover, water-soluble derivatives of vitamin E including some based on alphaTP are increasingly used as components of nanocarriers for enhanced and targeted delivery of drugs and other molecules (vitamins, including alphaT and alphaTP itself, vitamin D3, carnosine, caffeine, docosahexaenoic acid (DHA), insulin) and cofactors such as coenzyme Q10.	Water	10-15	insulin	Homo sapiens	306-313
29925069-9	2018	Since vasopressin secretion can be modulated by water intake, and its actions by selective receptor antagonists, the vasopressin-hydration system could be a potential therapeutic target for the prevention and treatment of diabetic nephropathy.	Water	48-53	arginine vasopressin	Homo sapiens	6-17
30305592-6	2018	To confirm the application of the fluorescent sensor, it was applied to determine the concentrations of mercury(II) ions in tap water, and the results showed that the method can be used to detect mercury(II) ions in water samples successfully.	Water	128-133	SEC14 like lipid binding 2	Homo sapiens	124-127
30305592-6	2018	To confirm the application of the fluorescent sensor, it was applied to determine the concentrations of mercury(II) ions in tap water, and the results showed that the method can be used to detect mercury(II) ions in water samples successfully.	Water	216-221	SEC14 like lipid binding 2	Homo sapiens	124-127
29925070-4	2018	The hypohydrated state provides a blood hyperosmotic stimulus for vasopressin release to minimise further water loss.	Water	106-111	arginine vasopressin	Homo sapiens	66-77
29925070-6	2018	Although suppressing vasopressin release with high water intake has been shown to impair disease progression in rodent models, whether this approach is efficacious in patients remains uncertain.	Water	51-56	arginine vasopressin	Homo sapiens	21-32
29241593-2	2018	The water deprivation test with assessment of AVP activity is currently the gold standard for differential diagnosis in patients presenting polyuria-polydipsia syndrome.	Water	4-9	arginine vasopressin	Homo sapiens	46-49
29170024-3	2018	BET BD1 and BD2 bromodomains differ at five positions near the substrate binding pocket: the variation in the ZA channel induces different water networks nearby.	Water	139-144	defensin beta 1	Homo sapiens	4-7
29136772-4	2018	METHODS: Apoe-/- mice were fed a high-fat diet and given water with or without TMAO for 8-week.	Water	57-62	apolipoprotein E	Mus musculus	9-13
29863081-5	2018	Interestingly, administration of YKS-containing water rescued attenuation of vasopressin-induced increase in serum corticosterone.	Water	48-53	arginine vasopressin	Rattus norvegicus	77-88
29303495-3	2018	It consists of a mononuclear unit with the CoII ion on an inversion centre coordinated by two 2,6-diamino-7H-purin-1-ium cations, two 4,4"-oxydibenzoate anions (in a nonbridging kappaO-monodentate coordination mode, which is less common for the anion in its CoII complexes) and two water molecules, defining an octahedral environment around the metal atom.	Water	282-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-47
29170024-3	2018	BET BD1 and BD2 bromodomains differ at five positions near the substrate binding pocket: the variation in the ZA channel induces different water networks nearby.	Water	139-144	defensin beta 4A	Homo sapiens	12-15
29158344-11	2018	GLP-1 concentrations were significantly higher in the water trial than in the land trial (P &lt; 0.05).	Water	54-59	glucagon	Homo sapiens	0-5
29108835-4	2018	The difference in PFAS concentrations between exposed and not exposed subjects was significantly larger for nine of the 12 substances analyzed, and confirmed that water contamination had resulted in an appreciable high exposure of the residing population over time.	Water	163-168	phosphoribosylformylglycinamidine synthase	Homo sapiens	18-22
29108835-6	2018	The contamination of drinking water of the residence area was found to be the main factor influencing PFAS serum levels; in addition to water contamination, other relevant influencing factors were sex, the years of residence and raising own livestock.	Water	30-35	phosphoribosylformylglycinamidine synthase	Homo sapiens	102-106
29107228-5	2018	The thyroperoxidase (TPO) inhibition assay and transthyretin (TTR) displacement assay (FITC) detected activity in the surface water and treated wastewater samples, but more work is required to assess if this activity is a true measure of thyroid activity or matrix interference.	Water	126-131	transthyretin L homeolog	Xenopus laevis	47-60
29107228-5	2018	The thyroperoxidase (TPO) inhibition assay and transthyretin (TTR) displacement assay (FITC) detected activity in the surface water and treated wastewater samples, but more work is required to assess if this activity is a true measure of thyroid activity or matrix interference.	Water	126-131	transthyretin L homeolog	Xenopus laevis	62-65
29145135-6	2018	When the exposition of river water to sunlight was partially limited and kept under the natural day-night cycle, as occurs inside a body of water, tenoxicam, piroxicam and meloxicam (at 2 mug L-1) were detected during a period of 15, 27 and 45 days, respectively.	Water	29-34	immunoglobulin kappa variable 1-16	Homo sapiens	192-195
29080503-5	2018	Ca2+ ions and neurotransmitters Glu and GABA affect hBest1 topology at the air/water interface altering its surface activity, size, orientation and organization.	Water	79-84	bestrophin 1	Homo sapiens	52-58
29080503-7	2018	We found that the binary films of hBest1 and POPC are phase separated at the air/water interface, suggesting stronger lipid-lipid and protein-protein interactions than lipid-protein interactions that can significantly alter the molecular organization and activity of hBest1 in cell membranes.	Water	81-86	bestrophin 1	Homo sapiens	34-40
28292234-1	2018	BACKGROUND: Due to the good biocompatibility, biodegradability, facile surface functionalization and high water solubility, Bovine serum albumin has gain increasing attention in the nanomedicine.	Water	106-111	albumin	Homo sapiens	131-144
29428952-0	2018	Transient Receptor Potential Ankyrin 1 and Substance P Mediate the Development of Gastric Mucosal Lesions in a Water Immersion Restraint Stress Rat Model.	Water	111-116	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	0-38
29428952-3	2018	We hypothesized that water immersion restraint stress (WIRS) may activate and sensitize TRPA1 in DRG neurons, subsequently inducing the release of SP from DRG and stomach cells, causing the development of acute gastric mucosal lesions (AGML).	Water	21-26	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	88-93
29108835-6	2018	The contamination of drinking water of the residence area was found to be the main factor influencing PFAS serum levels; in addition to water contamination, other relevant influencing factors were sex, the years of residence and raising own livestock.	Water	136-141	phosphoribosylformylglycinamidine synthase	Homo sapiens	102-106
29095570-2	2018	During the evolution from PBPs to Class A beta-lactamases, the beta-lactamases acquired Glu166 to activate a catalytic water and cleave the acyl-enzyme bond.	Water	119-124	amyloid beta precursor protein	Homo sapiens	40-46
29272792-8	2018	Molecular dynamic simulation (GROMACS 4.5.5) of hAChE-PEP complex for 4 x 104 pico-second with SPC16 water system at 310 K temperature explained the evident role of Trp86 in stabilizing the ligand at P-site of the enzyme.	Water	101-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	48-53
32291028-0	2018	Rapid changes in root HvPIP2;2 aquaporins abundance and ABA concentration are required to enhance root hydraulic conductivity and maintain leaf water potential in response to increased evaporative demand.	Water	144-149	PIP2;2	Hordeum vulgare	22-30
30010177-10	2018	A significant negative correlation was observed between extracellular water, provided in litres, and SHBG level.	Water	70-75	sex hormone binding globulin	Homo sapiens	101-105
29424356-1	2018	Water-soluble analogue of quercetin, corvitin is used in patients with myocardial infarction as blocker of 5-lipoxygenase.	Water	0-5	arachidonate 5-lipoxygenase	Homo sapiens	107-121
28081663-6	2018	This study focuses on analyses of 153 BACE1-ligand complexes for the direct contacts (hydrogen bonds and weak interactions) observed between protein and ligand and indirect contacts (water-mediated hydrogen bonds), observed in BACE1-ligand complex crystal structures.	Water	183-188	beta-secretase 1	Homo sapiens	38-43
29080206-7	2018	The GW182 RRM has a very dynamic structure, since water molecules can penetrate the whole domain in 2 h. The finding of this high structural dynamics sheds new light on the RRM structure.	Water	50-55	trinucleotide repeat containing adaptor 6A	Homo sapiens	4-9
28081663-6	2018	This study focuses on analyses of 153 BACE1-ligand complexes for the direct contacts (hydrogen bonds and weak interactions) observed between protein and ligand and indirect contacts (water-mediated hydrogen bonds), observed in BACE1-ligand complex crystal structures.	Water	183-188	beta-secretase 1	Homo sapiens	227-232
29842826-3	2018	It was speculated that higher electronic cloud density and lower water solubility of beta-CD than alpha-CD and RAMEB might favor to combination between acetylcholinesterase (AChE) and isomalathion included by beta-CD.	Water	65-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	152-172
28985596-6	2018	Inclusion of GO remarkably increased permeate flux of the membranes, so that pure water flux of PSF, PSF/GO 0.4% and PSF/GO 1.0% at operating pressure of 2 bar was determined 226, 449 and 512 L/m2 h, respectively.	Water	82-87	insulin like growth factor binding protein 7	Homo sapiens	96-99
28985596-6	2018	Inclusion of GO remarkably increased permeate flux of the membranes, so that pure water flux of PSF, PSF/GO 0.4% and PSF/GO 1.0% at operating pressure of 2 bar was determined 226, 449 and 512 L/m2 h, respectively.	Water	82-87	insulin like growth factor binding protein 7	Homo sapiens	101-104
28985596-6	2018	Inclusion of GO remarkably increased permeate flux of the membranes, so that pure water flux of PSF, PSF/GO 0.4% and PSF/GO 1.0% at operating pressure of 2 bar was determined 226, 449 and 512 L/m2 h, respectively.	Water	82-87	insulin like growth factor binding protein 7	Homo sapiens	101-104
28906027-0	2018	SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling.	Water	71-76	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	0-4
28906027-5	2018	Here, using co-immunoprecipitation and Forster resonance energy transfer, we report that AQP4 physically co-assembles with the sulfonylurea receptor 1-transient receptor potential melastatin 4 (SUR1-TRPM4) monovalent cation channel to form a novel heteromultimeric water/ion channel complex.	Water	265-270	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	194-198
28906027-6	2018	In vitro cell-swelling studies using calcein fluorescence imaging of COS-7 cells expressing various combinations of AQP4, SUR1, and TRPM4 showed that the full tripartite complex, comprised of SUR1-TRPM4-AQP4, was required for fast, high-capacity transmembrane water transport that drives cell swelling, with these findings corroborated in cultured primary astrocytes.	Water	260-265	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	192-196
28906027-8	2018	Together, these findings demonstrate a novel molecular mechanism involving the SUR1-TRPM4-AQP4 complex to account for bulk water influx during astrocyte swelling.	Water	123-128	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	79-83
30623697-7	2018	Limits of detection and quantitation of the 23 PFAS test compounds in water samples were 0.5-10 ng L-1 and 2-20 ng L-1, respectively.	Water	70-75	phosphoribosylformylglycinamidine synthase	Homo sapiens	47-51
30623697-7	2018	Limits of detection and quantitation of the 23 PFAS test compounds in water samples were 0.5-10 ng L-1 and 2-20 ng L-1, respectively.	Water	70-75	L1 cell adhesion molecule	Homo sapiens	99-102
30623697-7	2018	Limits of detection and quantitation of the 23 PFAS test compounds in water samples were 0.5-10 ng L-1 and 2-20 ng L-1, respectively.	Water	70-75	L1 cell adhesion molecule	Homo sapiens	115-118
30623697-9	2018	We used this method to determine PFAS levels in real water and suspended particle samples and found high sensitivity and good reproducibility.	Water	53-58	phosphoribosylformylglycinamidine synthase	Homo sapiens	33-37
29842826-3	2018	It was speculated that higher electronic cloud density and lower water solubility of beta-CD than alpha-CD and RAMEB might favor to combination between acetylcholinesterase (AChE) and isomalathion included by beta-CD.	Water	65-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	174-178
28826882-3	2018	Using this system, it is possible to encapsulate hydrophobic drugs in the inner aqueous core of the liposome based on the hypothesis that the water solubility of hydrophobic drugs is increased when bound to albumin.	Water	142-147	albumin	Homo sapiens	207-214
29389547-2	2018	Due to their higher water-holding, water absorption, and organic molecule absorption, chia seeds (CHIA) have been applied in powders, nutrition bars, breads, and cookies.	Water	20-25	chitinase acidic	Homo sapiens	86-90
29389547-2	2018	Due to their higher water-holding, water absorption, and organic molecule absorption, chia seeds (CHIA) have been applied in powders, nutrition bars, breads, and cookies.	Water	35-40	chitinase acidic	Homo sapiens	86-90
28632458-5	2018	AQP1, which is a water-selective channel, is expressed in the anterior chamber (cornea, ciliary body, trabecular meshwork) and posterior chamber (retina and microvessels in choroid), controlling the fluid homeostasis in the eye.	Water	17-22	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
29851012-6	2018	Superoxide dismutase (MnSOD, SOD2) from the mitochondrial matrix, as well as superoxide dismutase (Cu/ZnSOD, SOD1) present in small amounts in the mitochondrial intramembrane space, converts superoxide anion to hydrogen peroxide, which can be then converted by catalase to harmless H2O.In the chapter we describe a relation between mitochondrial membrane potential and the rate of ROS formation.	Water	282-285	superoxide dismutase 1	Homo sapiens	109-113
29456269-6	2018	During 120 h following the settling of the aggregates, denitrification of NO3- from the overlying water increased from 13.5 mumol m-2 h-1 to 24.3 mumol m-2 h-1, as quantified by 15N enrichment experiment.	Water	98-103	NBL1, DAN family BMP antagonist	Homo sapiens	74-77
29456269-10	2018	The produced NO3- was preferentially released into the overlying water and only a minor fraction contributed to denitrification activity.	Water	65-70	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
29456269-11	2018	Overall, our data indicate that the abrupt change in O2 microdistribution caused by aggregates stimulates denitrification of NO3- from the overlying water, and loosens the coupling between benthic nitrification and denitrification both in time and space.	Water	149-154	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
28843412-1	2018	In the syndrome of inappropriate antidiuretic hormone secretion (SIADH), hyponatremia is limited by onset of vasopressin-escape caused by loss of the water channel aquaporin-2 in the renal collecting duct despite high circulating vasopressin.	Water	150-155	arginine vasopressin	Rattus norvegicus	109-120
28843412-3	2018	Using single-tubule RNA-Seq, full transcriptomes were determined in microdissected cortical collecting ducts of vasopressin-treated rats at 1, 2, and 4 days after initiation of oral water loading in comparison to time-control rats without water loading.	Water	239-244	arginine vasopressin	Rattus norvegicus	112-123
30244794-3	2018	In this context, we report a simple, environmentally friendly, nonlabor-intensive method for the synthesis of colloidal graphene suspensions of 3-5 layers, stabilized by bovine serum albumin, in water.	Water	195-200	albumin	Homo sapiens	177-190
29886525-4	2018	Soluble Abeta is extracted by water-based buffers like phosphate-buffered saline-PBS-whereas pre-fibrillar and fibrillar deposits, usually poorly soluble in PBS, are extractable in detergent containing solutions or more stringent conditions as formic acid.	Water	30-35	amyloid beta precursor protein	Homo sapiens	8-13
29377837-1	2018	In this paper, a system consisting of acid-washed zero-valent iron (ZVI), ferrous ion (Fe2+), and hydrogen peroxide (H2O2) was employed for the removal of nitrate (NO3-) from water, and the reaction mechanism for this is discussed.	Water	175-180	NBL1, DAN family BMP antagonist	Homo sapiens	164-167
29109058-7	2018	Conversely, Homer2-cDNA was anxiogenic and increased drinking in water-drinking adolescents.	Water	65-70	homer scaffolding protein 2	Mus musculus	12-18
28914568-4	2018	RESULTS: Histological and behavioral evidence demonstrated that early systemic treatment with hESC-MSCs decreases the development of severe EAU in B10.RIII mice.	Water	140-143	granzyme C	Mus musculus	147-150
28914568-6	2018	CONCLUSIONS: MSCs that originate from hESC decrease the development of severe EAU in B10.RIII mice, likely through systemic immune modulation.	Water	78-81	granzyme C	Mus musculus	85-88
29175637-0	2018	Pectin and cellulose cell wall composition enables different strategies to leaf water uptake in plants from tropical fog mountain.	Water	80-85	zinc finger protein, FOG family member 1	Homo sapiens	117-120
29272929-2	2017	With this extrapolation method, a Mayer-sampling Monte Carlo simulation of the SPC/E (extended simple point charge) water model quantitatively predicted the second virial coefficient as a continuous function spanning over four orders of magnitude in value and over three orders of magnitude in temperature with less than a 2% deviation.	Water	116-121	proline rich protein gene cluster	Homo sapiens	79-82
29286340-1	2017	Solute carrier family 9 isoform 3 (SLC9A3), a Na+/H+ exchanger, regulates the transepithelial absorption of Na+ and water and is primarily expressed on the apical membranes of the intestinal epithelium, renal proximal tubule, epididymis, and vas deferens.	Water	116-121	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	35-41
29168638-3	2017	We explore the water-coupled dynamic structures of thromboxane synthase (TXAS) and prostacyclin synthase (PGIS) from scanning HPLC-SAXS measurements combined with MD ensemble analyses.	Water	15-20	thromboxane A synthase 1	Homo sapiens	51-71
29168638-3	2017	We explore the water-coupled dynamic structures of thromboxane synthase (TXAS) and prostacyclin synthase (PGIS) from scanning HPLC-SAXS measurements combined with MD ensemble analyses.	Water	15-20	thromboxane A synthase 1	Homo sapiens	73-77
29168638-3	2017	We explore the water-coupled dynamic structures of thromboxane synthase (TXAS) and prostacyclin synthase (PGIS) from scanning HPLC-SAXS measurements combined with MD ensemble analyses.	Water	15-20	prostaglandin I2 synthase	Homo sapiens	83-104
29168638-3	2017	We explore the water-coupled dynamic structures of thromboxane synthase (TXAS) and prostacyclin synthase (PGIS) from scanning HPLC-SAXS measurements combined with MD ensemble analyses.	Water	15-20	prostaglandin I2 synthase	Homo sapiens	106-110
29168638-6	2017	The use of homology modeling of the TXAS structure with ns-mus explicit water solvation MD simulations allows much more accurate estimation of the configuration space with loop motion and origin of the protein behaviors in solution.	Water	72-77	thromboxane A synthase 1	Homo sapiens	36-40
30416217-7	2018	This was evident in the LSH columns where the OM concentration was the highest and the AgNP content the lowest in the soil layers and in the effluent water.	Water	150-155	helicase, lymphoid specific	Homo sapiens	24-27
29267208-7	2017	It seems possible that AQP1 present in Gc and Tc cells may be implicated not only in the regulation of water homeostasis required for follicle development but also in cell proliferation and migration.	Water	103-108	aquaporin 1 (Colton blood group)	Homo sapiens	23-27
29137704-4	2017	The limit of detection ranged from 0.5 ng L-1 to 2 ng L-1 on the basis of 50 mL water sample; the recovery 79.9-119.1%; and the relative standard deviation 0.23%-9.82% (&gt;=5 replicates).	Water	80-85	immunoglobulin kappa variable 1-16	Homo sapiens	54-57
29031849-0	2017	Investigation of factors affecting the stability of lysozyme spray dried from ethanol-water solutions.	Water	86-91	lysozyme	Homo sapiens	52-60
29031849-2	2017	In this study, lysozyme was chosen as a model pharmaceutical protein to study these aspects when spray drying from water-ethanol mixtures.	Water	115-120	lysozyme	Homo sapiens	15-23
29031849-6	2017	Fourier Transform Infrared (FTIR) and Circular Dichroism (CD) results showed that the native structures of lysozyme were largely restored upon reconstitution of the spray dried powder in water after the spray drying process.	Water	187-192	lysozyme	Homo sapiens	107-115
29031849-7	2017	This suggests that the bioactivity of lysozyme could be preserved adequately by optimization of both the formulation composition and process conditions even when spray drying from a water-ethanol mixture.	Water	182-187	lysozyme	Homo sapiens	38-46
29140076-9	2017	Results show a similar reproducibility of both methods but reveal lower absolute lignin phenol yields in the humic-rich lake water samples upon C18 extraction.	Water	125-130	Bardet-Biedl syndrome 9	Homo sapiens	144-147
29141146-1	2017	Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy using a polymer coated internal reflection element/waveguide is an established sensor platform for the detection of a range of organic and hydrocarbon molecules dissolved in water.	Water	254-259	ATR serine/threonine kinase	Homo sapiens	57-60
29141146-3	2017	Crucial to reliable quantification and analytical performance is the calibration of the ATR-FTIR sensor which is commonly performed in water under mild ambient conditions (i.e., 25  C and 1 atm).	Water	135-140	ATR serine/threonine kinase	Homo sapiens	88-91
29258604-7	2017	RESULTS: Plasma and serum water T2 exhibited strong bivariate correlations with markers of insulin, lipids, inflammation, coagulation and electrolyte balance.	Water	26-31	insulin	Homo sapiens	91-98
29258604-9	2017	Plasma water T2 exhibited 100% sensitivity and 87% specificity for detecting early insulin resistance in normoglycemic subjects, as defined by the McAuley Index.	Water	7-12	insulin	Homo sapiens	83-90
29326556-0	2017	The Oxidative Stress-Induced Increase in the Membrane Expression of the Water-Permeable Channel Aquaporin-4 in Astrocytes Is Regulated by Caveolin-1 Phosphorylation.	Water	72-77	caveolin 1	Homo sapiens	138-148
29326556-10	2017	Together, these findings suggest that oxidative stress-induced Cav1 phosphorylation modulates AQP4 subcellular distribution and therefore may indirectly regulate AQP4-mediated water transport.	Water	176-181	caveolin 1	Homo sapiens	63-67
33365315-8	2017	Our evaluation demonstrates that-despite treatment of water with the BAMBi-E. coli, P aeruginosa, and S. typhimurium have the potential to grow during storage in the absence of microbial competition.	Water	54-59	BMP and activin membrane bound inhibitor	Homo sapiens	69-74
33365315-14	2017	Treatment including the BAMBi, GAC, and electrolysis appear to be promising technologies to control bacterial growth during storage in water intended for reuse.	Water	135-140	BMP and activin membrane bound inhibitor	Homo sapiens	24-29
28693108-8	2017	Our findings show aqueous phase NO3- from blasting residuals is present at highly variable initial concentrations in waste rock and the majority of this NO3- (&gt;75%) should be flushed by recharging water during displacement of the first stored water volume.	Water	200-205	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
28693108-8	2017	Our findings show aqueous phase NO3- from blasting residuals is present at highly variable initial concentrations in waste rock and the majority of this NO3- (&gt;75%) should be flushed by recharging water during displacement of the first stored water volume.	Water	200-205	NBL1, DAN family BMP antagonist	Homo sapiens	153-156
28693108-8	2017	Our findings show aqueous phase NO3- from blasting residuals is present at highly variable initial concentrations in waste rock and the majority of this NO3- (&gt;75%) should be flushed by recharging water during displacement of the first stored water volume.	Water	246-251	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
28434612-5	2017	The NO3-/Cl- ratio showed that, 98.4%, 95% and 64% of the NO3- in the borehole, hand dug wells and the surface water are from anthropogenic activities.	Water	111-116	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
29067388-3	2017	The mice fed with 3% l-carnitine water for 12 weeks experienced a disturbance of the hepatic lipid metabolism, oxidative stress and inflammation, which was evidenced by abnormal TC, LDL, RAHFR and MDA levels, unusual AST, ALT, ALP, SOD and GSP-Px activities, and increased IF-1, IF-6 and TNF-alpha expressions.	Water	33-38	transmembrane protease, serine 11d	Mus musculus	217-220
28434612-9	2017	Non carcinogenic health risk for adults and children posed by oral ingestion of the NO3- contaminated water revealed some degree of health risk, especially to children whose risk is about 72% higher.	Water	102-107	NBL1, DAN family BMP antagonist	Homo sapiens	84-87
29067377-4	2017	SPI-CG and SPI-CG-Qut complexes had a much smaller particle size when redispersed in water after spray drying, compared to those in the original dispersions (p &lt; 0.05).	Water	85-90	chromogranin A	Homo sapiens	0-3
29067377-4	2017	SPI-CG and SPI-CG-Qut complexes had a much smaller particle size when redispersed in water after spray drying, compared to those in the original dispersions (p &lt; 0.05).	Water	85-90	chromogranin A	Homo sapiens	11-14
29067388-3	2017	The mice fed with 3% l-carnitine water for 12 weeks experienced a disturbance of the hepatic lipid metabolism, oxidative stress and inflammation, which was evidenced by abnormal TC, LDL, RAHFR and MDA levels, unusual AST, ALT, ALP, SOD and GSP-Px activities, and increased IF-1, IF-6 and TNF-alpha expressions.	Water	33-38	NDV-induced circulating interferon	Mus musculus	273-283
29067388-3	2017	The mice fed with 3% l-carnitine water for 12 weeks experienced a disturbance of the hepatic lipid metabolism, oxidative stress and inflammation, which was evidenced by abnormal TC, LDL, RAHFR and MDA levels, unusual AST, ALT, ALP, SOD and GSP-Px activities, and increased IF-1, IF-6 and TNF-alpha expressions.	Water	33-38	tumor necrosis factor	Mus musculus	288-297
29111764-2	2017	Here, we explore the water sensing mechanism of InN thin films.	Water	21-26	growth hormone releasing hormone	Homo sapiens	48-51
29111764-5	2017	Our intuitive model provides a novel route toward understanding the water sensing mechanism in InN and, more generally, for understanding sensing material systems beyond InN.	Water	68-73	growth hormone releasing hormone	Homo sapiens	95-98
29111764-5	2017	Our intuitive model provides a novel route toward understanding the water sensing mechanism in InN and, more generally, for understanding sensing material systems beyond InN.	Water	68-73	growth hormone releasing hormone	Homo sapiens	170-173
29076608-0	2017	Efficient Water Reduction with sp3 -sp3 Diboron(4) Compounds: Application to Hydrogenations, H-D Exchange Reactions, and Carbonyl Reductions.	Water	10-15	Sp3 transcription factor	Homo sapiens	31-34
29311961-4	2017	We found that administrations of octopamine (the invertebrate counterpart of noradrenaline) and dopamine receptor antagonists impair conditioning to associate an olfactory or visual conditioned stimulus (CS) with water or sodium chloride solution (appetitive or aversive unconditioned stimulus, US), respectively, suggesting that specific octopamine and dopamine neurons mediate appetitive and aversive signals, respectively, in conditioning in crickets.	Water	213-218	Dopamine 1-like receptor 1	Drosophila melanogaster	96-113
29076608-0	2017	Efficient Water Reduction with sp3 -sp3 Diboron(4) Compounds: Application to Hydrogenations, H-D Exchange Reactions, and Carbonyl Reductions.	Water	10-15	Sp3 transcription factor	Homo sapiens	36-39
29076608-1	2017	A series of crystalline sp3 -sp3 diboron(4) compounds were synthesized and shown to promote the facile reduction of water with dihydrogen formation.	Water	116-121	Sp3 transcription factor	Homo sapiens	24-27
29076608-1	2017	A series of crystalline sp3 -sp3 diboron(4) compounds were synthesized and shown to promote the facile reduction of water with dihydrogen formation.	Water	116-121	Sp3 transcription factor	Homo sapiens	29-32
29964561-2	2017	It was found that the levels of THg, dissolved mercury, and particulate mercury in the water ranged from 1.65-9.65, 0.80-3.16, and 0.70-7.81 ng L-1, respectively.	Water	87-92	immunoglobulin kappa variable 1-16	Homo sapiens	144-147
29222949-1	2017	Hypothalamic magnocellular neurons secrete vasopressin into the systemic circulation to maintain blood pressure by increasing renal water reabsorption and by vasoconstriction.	Water	132-137	arginine vasopressin	Homo sapiens	43-54
29964561-4	2017	The amounts of MeHg, dissolved MeHg, and particulate MeHg in the water samples were 0.05-0.36, 0.02-0.14, and ND-0.26 ng L-1, respectively.	Water	65-70	immunoglobulin kappa variable 1-16	Homo sapiens	121-124
29964562-8	2017	There was a significant relationship between NO3- and Cl-, indicating that mixing processes occurred in the surface water during the two sampling periods.	Water	116-121	NBL1, DAN family BMP antagonist	Homo sapiens	45-48
29340084-4	2017	More recently, salivary gland gene therapy utilizing the water-specific protein aquaporin 1 (AQP1) has been of great interest to potentially correct salivary dysfunction.	Water	57-62	aquaporin 1 (Colton blood group)	Homo sapiens	80-91
29221375-4	2017	We apply our method on SPC/E water, where we find a conservation of the average water structure.	Water	29-34	surfactant protein C	Homo sapiens	23-26
29221375-4	2017	We apply our method on SPC/E water, where we find a conservation of the average water structure.	Water	80-85	surfactant protein C	Homo sapiens	23-26
29221389-5	2017	Such behavior signals the presence of highly selective nuclear spin ortho-para predissociation dynamics in the upper state, for which we offer a simple mechanism based on Ne-atom mediated intramolecular vibrational relaxation in the H2O subunit (i.e.,  02+-)   { 01+-); v2 = 2}), which is confirmed by the ab initio energy level predictions and the nascent OH rotational (N), spin orbit (Pi1/2,3/2), and lambda doublet product distributions.	Water	233-236	serpin family A member 1	Homo sapiens	388-397
29376971-0	2017	[One-time effects of drinking mineral water and tap water enriched with silver nanoparticles on the biochemical markers of liver condition and metabolic parameters in healthy rats].	Water	52-57	nuclear RNA export factor 1	Rattus norvegicus	48-51
29376971-1	2017	AIM:  The objective of the present research was to study the influence of tap water enriched with silver nanoparticles (NP) as well as that of &lt;&lt;Krasnoarmeysky&gt;&gt; and &lt;&lt;Essentuki No17&gt;&gt; mineral waters after their single administration through the oral gavage to the rats on the metabolism of carbohydrates and lipids, the biochemical markers of the liver condition, and the endocrine profile in the healthy animals.	Water	78-83	nuclear RNA export factor 1	Rattus norvegicus	74-77
29376971-3	2017	RESULTS:  The study has demonstrated that the tap water enriched with silver nanoparticles similar to the mineral waters caused stress reactions that are inferior to those induced by &lt;&lt;Essentuki No17&gt;&gt; mineral water in terms of the magnitude; however, the effect provoked by the tap water was of longer duration.	Water	50-55	nuclear RNA export factor 1	Rattus norvegicus	46-49
29376971-3	2017	RESULTS:  The study has demonstrated that the tap water enriched with silver nanoparticles similar to the mineral waters caused stress reactions that are inferior to those induced by &lt;&lt;Essentuki No17&gt;&gt; mineral water in terms of the magnitude; however, the effect provoked by the tap water was of longer duration.	Water	50-55	nuclear RNA export factor 1	Rattus norvegicus	291-294
29376971-4	2017	Moreover, the tap water enriched with silver nanoparticles stimulates prooxidant reactions, and inhibit the activity of antioxidant protection.	Water	18-23	nuclear RNA export factor 1	Rattus norvegicus	14-17
29376971-6	2017	CONCLUSION:  The silver nanoparticles present in the tap water have a significant biological potential of their own.	Water	57-62	nuclear RNA export factor 1	Rattus norvegicus	53-56
29376971-8	2017	The single intake of the tap water enriched with silver nanoparticles by the healthy laboratory animals produces the response that resembles that of the drinking mineral water.	Water	29-34	nuclear RNA export factor 1	Rattus norvegicus	25-28
29376971-8	2017	The single intake of the tap water enriched with silver nanoparticles by the healthy laboratory animals produces the response that resembles that of the drinking mineral water.	Water	170-175	nuclear RNA export factor 1	Rattus norvegicus	25-28
29125304-0	2017	Homogeneous Nucleation of Ice in Transiently-Heated, Supercooled Liquid Water Films.	Water	72-77	carboxylesterase 2	Homo sapiens	26-29
29125304-1	2017	We have investigated the nucleation and growth of crystalline ice in 0.24 mum thick, supercooled water films adsorbed on Pt(111).	Water	97-102	carboxylesterase 2	Homo sapiens	62-65
29125304-4	2017	The experimental conditions were chosen to suppress ice nucleation at both the water/metal and water/vacuum interfaces.	Water	79-84	carboxylesterase 2	Homo sapiens	52-55
29125304-4	2017	The experimental conditions were chosen to suppress ice nucleation at both the water/metal and water/vacuum interfaces.	Water	95-100	carboxylesterase 2	Homo sapiens	52-55
29541662-0	2018	Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates.	Water	106-111	ATP binding cassette subfamily B member 1	Homo sapiens	75-79
29340084-4	2017	More recently, salivary gland gene therapy utilizing the water-specific protein aquaporin 1 (AQP1) has been of great interest to potentially correct salivary dysfunction.	Water	57-62	aquaporin 1 (Colton blood group)	Homo sapiens	93-97
28971841-5	2017	Oral administration of taurine [1% or 4% (wt/vol) in drinking water], an amino acid known to react rapidly with MPO-generated oxidants like hypochlorous acid, also prevented AAA formation in the ANG II and elastase models as well as the CaCl2 application model of AAA formation while reducing aortic peroxidase activity and aortic protein-bound dityrosine levels, an oxidative cross link formed by MPO.	Water	62-67	myeloperoxidase	Homo sapiens	112-115
28945012-6	2017	The present work shows that thousands of polyethylene glycol (PEG) chains modified with lysines and functionalized with GE11 on clusters of naked gold nanoparticles, obtained by laser ablation in water, achieves a better targeting activity than that recorded with nanoparticles decorated with the specific anti-EGFR antibody Cetuximab (C225).	Water	196-201	epidermal growth factor receptor	Homo sapiens	311-315
28971841-5	2017	Oral administration of taurine [1% or 4% (wt/vol) in drinking water], an amino acid known to react rapidly with MPO-generated oxidants like hypochlorous acid, also prevented AAA formation in the ANG II and elastase models as well as the CaCl2 application model of AAA formation while reducing aortic peroxidase activity and aortic protein-bound dityrosine levels, an oxidative cross link formed by MPO.	Water	62-67	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	195-201
29224666-2	2017	Studies in rats and mice have shown that vasopressin produced by magnocellular neurosecretory cells (MNCs) that project to the neurohypophysis is released into the blood circulation where it serves as an antidiuretic hormone to promote water reabsorption from the kidney.	Water	236-241	arginine vasopressin	Rattus norvegicus	41-52
28573605-4	2017	The aim of the present study was to inhibit the biofilm formed by ESBL-producing Escherichia coli using silver nanoparticles (AgNPs) synthesized with fresh water diatom (Nitzschia palea).	Water	156-161	EsbL	Escherichia coli	66-70
29224666-4	2017	In this chapter, we review recent cellular and network level studies in rodents that have provided insight into how circadian rhythms in vasopressin mediate changes in water intake behavior and renal water conservation that protect the body against dehydration during sleep.	Water	168-173	arginine vasopressin	Rattus norvegicus	137-148
29224666-4	2017	In this chapter, we review recent cellular and network level studies in rodents that have provided insight into how circadian rhythms in vasopressin mediate changes in water intake behavior and renal water conservation that protect the body against dehydration during sleep.	Water	200-205	arginine vasopressin	Rattus norvegicus	137-148
28892774-5	2017	The observed leaching trends of AsV, AsIII, SeIV and SeVI were satisfactorily simulated by one-dimensional reactive transport models, which predict that preferential adsorptions of AsV and SeIV were magnified by geochemical changes in the columns due to water flow.	Water	254-259	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	181-184
29285131-12	2017	In conclusion, water extracts of Rehmannia glutinosa effectively reversed the glucose metabolism disorder in insulin resistance mice induced by paraquat, and effectively activated the level of Nrf-2 to enhance the muscle insulin signal while alleviating the insulin resistance in mice.	Water	15-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	193-198
28922633-3	2017	Bovine serum albumin (BSA) and cytochrome c partitioned to the BmuE phase at 64% and 81% efficiency, respectively, producing highly concentrated protein solutions (32 and 44gL-1, respectively), through release of water and oil from the BmuEs.	Water	213-218	cytochrome c, somatic	Homo sapiens	31-43
28929288-6	2017	The concentrations of paper manufacturing chemicals in river water-for example, of the endocrine-disrupting compound bisphenol A (50-8000 ng L-1)-were as high as in pure untreated paper industry wastewaters.	Water	61-66	immunoglobulin kappa variable 1-16	Homo sapiens	141-144
28901245-7	2017	Surface water concentrations for PFOS ranged from 16 to 122 ng L-1 and input water concentrations were 132 ng L-1 and 206 ng L-1.	Water	8-13	immunoglobulin kappa variable 1-16	Homo sapiens	63-66
29285131-0	2017	Effects of water extracts of Rehmannia glutinosa on antioxidant system of Nrf2 in paraquat-induced insulin resistance diabetic rat model.	Water	11-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	74-78
28901245-7	2017	Surface water concentrations for PFOS ranged from 16 to 122 ng L-1 and input water concentrations were 132 ng L-1 and 206 ng L-1.	Water	77-82	immunoglobulin kappa variable 1-16	Homo sapiens	110-113
28901245-7	2017	Surface water concentrations for PFOS ranged from 16 to 122 ng L-1 and input water concentrations were 132 ng L-1 and 206 ng L-1.	Water	77-82	immunoglobulin kappa variable 1-16	Homo sapiens	110-113
28901245-8	2017	Of the eight water samples, seven had water concentrations that exceeded the EPA health advisory level for PFOS of 70 ng L-1.	Water	13-18	immunoglobulin kappa variable 1-16	Homo sapiens	121-124
28901245-8	2017	Of the eight water samples, seven had water concentrations that exceeded the EPA health advisory level for PFOS of 70 ng L-1.	Water	38-43	immunoglobulin kappa variable 1-16	Homo sapiens	121-124
29285131-1	2017	The objective of this study was to observe the effects of water extracts of Rehmannia glutinosa on the antioxidant system of Nrf-2 in diabetic mice induced by paraquat, and to provide the basis for its further development.	Water	58-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-130
29293799-1	2017	The study was to determine whether the expression of genes involved in intestinal water and ion transport would be affected by enterotoxigenic (ETEC) K88 both in vitro and in vivo.	Water	82-87	ETEC	Sus scrofa	144-148
29285131-10	2017	With decreased NQO-1 protein expression and the nuclear translocation of Nrf-2 in the model group, the water extract of Rehmannia glutinosa cloud reverse the injury effectively.	Water	103-108	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-78
28283455-0	2017	Synthesis of water-dispersible poly-l-lysine-functionalized magnetic Fe3O4-(GO-MWCNTs) nanocomposite hybrid with a large surface area for high-efficiency removal of tartrazine and Pb(II).	Water	13-18	submaxillary gland androgen regulated protein 3B	Homo sapiens	180-186
31966519-0	2017	Effects of S100A12 reduction on H2O2-induced injury of human vascular smooth muscle cells (HVSMCs).	Water	32-36	S100 calcium binding protein A12	Homo sapiens	11-18
31966519-3	2017	The aim of the present study was to investigate the protective effects of S100A12 reduction on hydrogen peroxide (H2O2)-induced human vascular smooth muscle cells (HVSMCs) injury and evaluate the relevance of S100A12 and aortic disease.	Water	114-118	S100 calcium binding protein A12	Homo sapiens	74-81
31966519-4	2017	In this study, HVSMCs were exposed to the H2O2 in the presence or absence of S100A12, then cell viability was detected by MTT assay, cell apoptosis was performed with the flow cytometry kit, IL-6 and TNFalpha production evaluated by ELISA and apoptotic proteins were investigated by western blot.	Water	42-46	S100 calcium binding protein A12	Homo sapiens	77-84
28762291-8	2017	Severity of appendicitis can be correlated with water permeability measured by AQP1 protein expression and increase of ganglia count in a progressive manner.	Water	48-53	aquaporin 1 (Colton blood group)	Homo sapiens	79-83
28643395-1	2017	Catalase is an antioxidative enzyme that converts hydrogen peroxide (H2 O2 ) produced by superoxide dismutase from highly reactive superoxide (O2- ) to water and oxygen molecules.	Water	152-157	catalase	Mus musculus	0-8
29147837-9	2017	These observations as well as the representative structures obtained by clustering analysis were in reasonable agreement not only with the structures of C-peptide that were determined in this study by NMR in 30% CD3CD in H2O at 298 K but also with the experimental and theoretical behaviors having been reported for protonated C-peptide.	Water	221-224	insulin	Homo sapiens	153-162
29153154-16	2017	We now know that supplementation of specific water-soluble vitamins can enhance cow health and increase milk production in certain situations.	Water	45-50	Weaning weight-maternal milk	Bos taurus	104-108
28783009-5	2017	Results show that the maximum projected supply of new water, 2.47 million acre-feet per year (MAF/yr), is sufficient to meet low depletion estimates of 2.02 MAF/yr, but fails to come near the high depletion estimate of 3.44 MAF/yr.	Water	54-59	MAF bZIP transcription factor	Homo sapiens	94-97
29119840-4	2017	With increasing the revolution velocity (Nr1), the content and the microencapsulation efficiency of the inner water droplets increased, while those of the oil phase decreased.	Water	110-115	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	41-44
28783009-5	2017	Results show that the maximum projected supply of new water, 2.47 million acre-feet per year (MAF/yr), is sufficient to meet low depletion estimates of 2.02 MAF/yr, but fails to come near the high depletion estimate of 3.44 MAF/yr.	Water	54-59	MAF bZIP transcription factor	Homo sapiens	157-160
28783009-5	2017	Results show that the maximum projected supply of new water, 2.47 million acre-feet per year (MAF/yr), is sufficient to meet low depletion estimates of 2.02 MAF/yr, but fails to come near the high depletion estimate of 3.44 MAF/yr.	Water	54-59	MAF bZIP transcription factor	Homo sapiens	157-160
28783009-7	2017	By including capacities in demand-substitutability via urban water conservation, maximum predicted capacities reach 5.57 MAF/yr, indicating wide room for substitution.	Water	61-66	MAF bZIP transcription factor	Homo sapiens	121-124
29119840-3	2017	The mean diameters of the inner water droplets and those of the microcapsules were proportional to Nr1-1.25 and Nr1-0.11 for the revolution velocity (Nr1), respectively.	Water	32-37	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	99-102
29119840-6	2017	The content and the microencapsulation efficiency of the inner water droplets and those of the oil phase decreased with the revolution velocity (Nr1) and increased with the lecithin concentration.	Water	63-68	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	145-148
29119840-3	2017	The mean diameters of the inner water droplets and those of the microcapsules were proportional to Nr1-1.25 and Nr1-0.11 for the revolution velocity (Nr1), respectively.	Water	32-37	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	112-115
29119840-3	2017	The mean diameters of the inner water droplets and those of the microcapsules were proportional to Nr1-1.25 and Nr1-0.11 for the revolution velocity (Nr1), respectively.	Water	32-37	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	112-115
28535594-5	2017	Both organic and water-soluble PM2.5 extracts induced activation of the RhoA/ROCK pathway.	Water	17-22	ras homolog family member A	Homo sapiens	72-76
31966519-5	2017	The results showed that H2O2 inhibited cell proliferation, induced cell apoptosis, IL-6 and TNFalpha release, the increase of caspase-3 protein and the decrease of Bcl-2, while transfection with S10012A shRNA significantly repaired the situation above.	Water	24-28	interleukin 6	Homo sapiens	83-87
31966519-5	2017	The results showed that H2O2 inhibited cell proliferation, induced cell apoptosis, IL-6 and TNFalpha release, the increase of caspase-3 protein and the decrease of Bcl-2, while transfection with S10012A shRNA significantly repaired the situation above.	Water	24-28	tumor necrosis factor	Homo sapiens	92-100
31966519-5	2017	The results showed that H2O2 inhibited cell proliferation, induced cell apoptosis, IL-6 and TNFalpha release, the increase of caspase-3 protein and the decrease of Bcl-2, while transfection with S10012A shRNA significantly repaired the situation above.	Water	24-28	BCL2 apoptosis regulator	Homo sapiens	164-169
31966519-6	2017	Our findings suggested that reduction of S100A12 protects HVSMCs against H2O2-induced injury, and may be useful as a treatment for aortic disease.	Water	73-77	S100 calcium binding protein A12	Homo sapiens	41-48
29039533-11	2017	SIRT1 may reduce the brain water content by improvement of dysfunctional BBB permeability, and protein analysis revealed that both ZO-1, occludin and claudin-5 may be involved, and these effects were reversed by SIRT1 inhibition.	Water	27-32	sirtuin 1	Rattus norvegicus	0-5
29225432-5	2017	It is of interest model the HIF-1 dimer protein and protein was subjected to molecular dynamics simulations using NAMD 2.9 software with CHARMM27 force field in water and the protein structure was minimized with 25000 steps for 500 ps and simulation with 1000000 steps for 2ns.	Water	161-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
29123019-2	2017	Herein we demonstrate that a photoredox-mediated hydrogen atom transfer protocol can efficiently and selectively install deuterium (D) and tritium (T) at alpha-amino sp3 carbon-hydrogen bonds in a single step, using isotopically labeled water (D2O or T2O) as the source of hydrogen isotope.	Water	237-242	Sp3 transcription factor	Homo sapiens	166-169
28965033-5	2017	The permeability of the ozone pre-treated water through the ceramic membrane was found to decrease to 50% of the original value after 200 min of operation, compared to approximately 10% of the original value for the BAC pre-treated, O3+BAC pre-treated water and the untreated water.	Water	42-47	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	233-239
28965033-5	2017	The permeability of the ozone pre-treated water through the ceramic membrane was found to decrease to 50% of the original value after 200 min of operation, compared to approximately 10% of the original value for the BAC pre-treated, O3+BAC pre-treated water and the untreated water.	Water	252-257	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	233-239
28965033-5	2017	The permeability of the ozone pre-treated water through the ceramic membrane was found to decrease to 50% of the original value after 200 min of operation, compared to approximately 10% of the original value for the BAC pre-treated, O3+BAC pre-treated water and the untreated water.	Water	252-257	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	233-239
29196744-8	2017	By combining this system with the Drosophila genetics tools, we could confirm a role for ppk28 and DopR1 in promoting water consumption, and through functional investigation of RNAseq data from dehydrated animals, we found DopR1 expression in the mushroom body was sufficient to drive consumption and enhance water taste sensitivity.	Water	118-123	Dopamine 1-like receptor 1	Drosophila melanogaster	99-104
29196744-8	2017	By combining this system with the Drosophila genetics tools, we could confirm a role for ppk28 and DopR1 in promoting water consumption, and through functional investigation of RNAseq data from dehydrated animals, we found DopR1 expression in the mushroom body was sufficient to drive consumption and enhance water taste sensitivity.	Water	309-314	Dopamine 1-like receptor 1	Drosophila melanogaster	223-228
29187641-1	2017	Arginine vasopressin (AVP) made by hypothalamic neurons is released into the circulation to stimulate water resorption by the kidneys and restore water balance after blood loss.	Water	102-107	arginine vasopressin	Homo sapiens	9-20
28910862-10	2017	Ten days after the sample injection, the Morris water maze test confirmed that exogenous Abeta caused an increase in memory loss.	Water	48-53	amyloid beta precursor protein	Homo sapiens	89-94
29187641-1	2017	Arginine vasopressin (AVP) made by hypothalamic neurons is released into the circulation to stimulate water resorption by the kidneys and restore water balance after blood loss.	Water	102-107	arginine vasopressin	Homo sapiens	22-25
29160802-9	2017	Contrariwise, the modification of the surface chemistry increased the apparent dielectric constant of NaF-water solution by promoting fluoride transmission.	Water	106-111	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
29186911-2	2017	The process of targeting the water channel aquaporin-2 (AQP2) on the apical plasma membrane of the collecting duct (CD) principal cells is mainly regulated by the antidiuretic peptide hormone arginine vasopressin (AVP), which is responsible for the maintenance of water homeostasis.	Water	29-34	arginine vasopressin	Homo sapiens	201-212
29094932-4	2017	Herein, m-phenylenediamine (mPD) is used as a precursor to prepare carbon dots (named m-CDs) with highly fluorescent quantum yield (31.58% in water), and our investigation shows that the strong fluorescent emission of m-CDs can be effectively quenched by ClO-.	Water	142-147	mevalonate (diphospho) decarboxylase	Mus musculus	28-31
29165388-2	2017	Male Sprague-Dawley rats had free access to a drinking solution containing 10% d-glucose or tap water for 12 weeks.	Water	96-101	nuclear RNA export factor 1	Rattus norvegicus	92-95
29166117-0	2017	Adsorption and conformations of lysozyme and alpha-lactalbumin at a water-octane interface.	Water	68-73	lysozyme	Homo sapiens	32-40
29166117-0	2017	Adsorption and conformations of lysozyme and alpha-lactalbumin at a water-octane interface.	Water	68-73	lactalbumin alpha	Homo sapiens	45-62
29166117-5	2017	In this paper, molecular dynamics simulations are used to investigate the adsorption and conformation of two similar proteins, lysozyme and alpha-lactalbumin, at a water-octane interface.	Water	164-169	lysozyme	Homo sapiens	127-135
29099531-2	2017	After introducing a secondary amide as a hydrogen-bonding crosslinking motif into the side chain of the PPO backbone, the membrane exhibits high mechanical strength and excellent flexibility (101% elongation at break), as well as suppressed water uptake, enhanced thermal stability and good fuel cell performances.	Water	241-246	protoporphyrinogen oxidase	Homo sapiens	104-107
29166117-5	2017	In this paper, molecular dynamics simulations are used to investigate the adsorption and conformation of two similar proteins, lysozyme and alpha-lactalbumin, at a water-octane interface.	Water	164-169	lactalbumin alpha	Homo sapiens	140-157
29166117-8	2017	Decomposing the different contributions to the protein energy at oil-water interfaces suggests that conformational change for alpha-lactalbumin, unlike lysozyme, is driven by favourable protein-oil interactions.	Water	69-74	lactalbumin alpha	Homo sapiens	126-143
29040802-0	2017	Freezing Temperatures, Ice Nanotubes Structures, and Proton Ordering of TIP4P/ICE Water inside Single Wall Carbon Nanotubes.	Water	82-87	carboxylesterase 2	Homo sapiens	78-81
29040802-3	2017	We present here results from molecular dynamics simulations of water inside single walled carbon nanotubes using an extremely realistic model for both liquid and icy water, the TIP4P/ICE.	Water	63-68	carboxylesterase 2	Homo sapiens	183-186
29040802-7	2017	We have also analyzed the ice structure called "ice nanotube" that water forms inside the single walled carbon nanotubes when it freezes.	Water	67-72	carboxylesterase 2	Homo sapiens	26-29
29040802-7	2017	We have also analyzed the ice structure called "ice nanotube" that water forms inside the single walled carbon nanotubes when it freezes.	Water	67-72	carboxylesterase 2	Homo sapiens	48-51
29040802-8	2017	The ice forms observed are in agreement with previous results obtained with different water models.	Water	86-91	carboxylesterase 2	Homo sapiens	4-7
28578571-1	2017	We have developed an efficient method for direct formation of epoxide groups from carbon(sp2)-carbon(sp3) single bonds of beta-keto esters; the reaction is mediated by the water-soluble hypervalent iodine(V) reagent AIBX (5-trimethylammonio-1,3-dioxo-1,3-dihydro-1lambda5-benzo[d][1,2]iodoxol-1-ol anion).	Water	172-177	Sp2 transcription factor	Homo sapiens	89-92
28578571-1	2017	We have developed an efficient method for direct formation of epoxide groups from carbon(sp2)-carbon(sp3) single bonds of beta-keto esters; the reaction is mediated by the water-soluble hypervalent iodine(V) reagent AIBX (5-trimethylammonio-1,3-dioxo-1,3-dihydro-1lambda5-benzo[d][1,2]iodoxol-1-ol anion).	Water	172-177	Sp3 transcription factor	Homo sapiens	101-104
29078957-6	2017	The detection limits obtained on xylitol resulted 180 mg L-1 (CV% = 6.9) and 44 mg L-1 (CV% = 6.5) in water and oral fluid, respectively.	Water	102-107	immunoglobulin kappa variable 1-16	Homo sapiens	83-86
28778382-5	2017	Denitrification of water column NO3- was more significant than coupled nitrification-denitrification in the eelgrass.	Water	19-24	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
29132429-7	2017	Correlation analysis elucidated that the water content was strongly correlated with local skin indices, such as the ceramide composition, redness, blood flow, and TNFalpha in the stratum corneum, whereas roughness was correlated with the systemic indices, such as serum insulin, leptin, and IL-6.	Water	41-46	tumor necrosis factor	Homo sapiens	163-171
29131815-4	2017	Here, we discovered that mutations in KARRIKIN INSENSITIVE2 (KAI2), encoding the proposed karrikin receptor, result in hypersensitivity to water deprivation.	Water	139-144	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	38-59
29131815-4	2017	Here, we discovered that mutations in KARRIKIN INSENSITIVE2 (KAI2), encoding the proposed karrikin receptor, result in hypersensitivity to water deprivation.	Water	139-144	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	61-65
29132429-7	2017	Correlation analysis elucidated that the water content was strongly correlated with local skin indices, such as the ceramide composition, redness, blood flow, and TNFalpha in the stratum corneum, whereas roughness was correlated with the systemic indices, such as serum insulin, leptin, and IL-6.	Water	41-46	insulin	Homo sapiens	270-277
29131815-6	2017	We found that kai2 mutants have increased rates of water loss and drought-induced cell membrane damage, enlarged stomatal apertures, and higher cuticular permeability.	Water	51-56	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	14-18
29132429-7	2017	Correlation analysis elucidated that the water content was strongly correlated with local skin indices, such as the ceramide composition, redness, blood flow, and TNFalpha in the stratum corneum, whereas roughness was correlated with the systemic indices, such as serum insulin, leptin, and IL-6.	Water	41-46	interleukin 6	Homo sapiens	291-295
29119330-8	2017	And the standard multiple regression describing the relationship between sediment P flux potential in sediment-water interface and its major effect factors was Y = 5.849 - 1.025X 1 - 1.995X 2 + 0.188X 3 - 0.282X 4 (r = 0.9298, p &lt; 0.01, n = 96), where Y is sediment P flux potential in sediment-water interface, X 1 is sediment Ca-P content, X 2 is sediment Olsen-P content, X 3 is sediment SOC content, and X 4 is sediment Al-P content.	Water	111-116	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	199-202
29124366-5	2017	The water temperatures are consistently above 25  C, which impairs dissolved oxygen levels (3.1 to 6.7 mg L-1) and may suggest eutrophication.	Water	4-9	L1 cell adhesion molecule	Homo sapiens	106-109
29083896-0	2017	Filling Blank Spots on the Map: Identification of Ligand Binding Modes and Interacting Water Molecules for Brd4-BD1 by WaterLOGSY Titrations.	Water	87-92	bromodomain containing 4	Homo sapiens	107-111
29083896-0	2017	Filling Blank Spots on the Map: Identification of Ligand Binding Modes and Interacting Water Molecules for Brd4-BD1 by WaterLOGSY Titrations.	Water	87-92	defensin beta 1	Homo sapiens	112-115
30344448-7	2017	The two neat polymorphs are enantiotropically related and water-free o-phen transforms to Hy1 at RH &gt; 16%.	Water	58-63	RNA, Ro60-associated Y1	Homo sapiens	90-93
28972369-4	2017	After evaporation of water, the oxidation products can be directly analyzed from the sample spots by DESI-MS, using a commercial rotating sample platform.	Water	21-26	desumoylating isopeptidase 2	Homo sapiens	101-105
29020453-9	2017	Studies of the hydration of full-length R67 DHFR in the presence of the osmolytes betaine and dimethyl sulfoxide find around 1250 water molecules hydrating the protein.	Water	130-135	dihydrofolate reductase	Escherichia coli	44-48
29020453-10	2017	Similar studies with truncated R67 DHFR yield around 400 water molecules hydrating the protein in the presence of betaine.	Water	57-62	dihydrofolate reductase	Escherichia coli	35-39
29965398-2	2017	These results showed that macrolides have the highest average concentration of all antibiotics in the surface water of the LRB of 201.88 ng L-1, followed by quinolones, trimethoprim, and sulfonamides with average concentrations of 113.40 ng L-1, 93.93 ng L-1, and 124.27 ng L-1, respectively.	Water	110-115	L1 cell adhesion molecule	Homo sapiens	140-143
29028346-8	2017	Molecular dynamics simulation of a model APT chain in a water box supports the threading at lower pH where the iodide ions pose nearer to the PT chain than that at higher pH causing dethreading.	Water	56-61	LYPLA2 pseudogene 1	Homo sapiens	41-44
28979952-3	2017	The BCNT photocatalysts can catalyse hydrogen evolution from water under visible light illumination.	Water	61-66	craniofacial development protein 1	Homo sapiens	4-8
28845886-0	2017	The Role of Water Distribution Controlled by Transmembrane Potentials in the Cytochrome c-Cardiolipin Interaction: Revealing from Surface-Enhanced Infrared Absorption Spectroscopy.	Water	12-17	cytochrome c, somatic	Homo sapiens	77-89
28845886-1	2017	The interaction of cytochrome c (cyt c) with cardiolipin (CL) plays a crucial role in apoptotic functions, however, the changes of the transmembrane potential in governing the protein behavior at the membrane-water interface have not been studied due to the difficulties in simultaneously monitoring the interaction and regulating the electric field.	Water	209-214	cytochrome c, somatic	Homo sapiens	19-31
28845886-1	2017	The interaction of cytochrome c (cyt c) with cardiolipin (CL) plays a crucial role in apoptotic functions, however, the changes of the transmembrane potential in governing the protein behavior at the membrane-water interface have not been studied due to the difficulties in simultaneously monitoring the interaction and regulating the electric field.	Water	209-214	cytochrome c, somatic	Homo sapiens	33-38
28845886-3	2017	When the transmembrane potential decreases, the water content at the interface of the membranes can be increased to slow down protein adsorption through decreasing the hydrogen-bond and hydrophobic interactions, but regulates the redox behavior of CL-bound cyt c through a possible water-facilitated proton-coupled electron transfer process.	Water	48-53	cytochrome c, somatic	Homo sapiens	257-262
29052412-0	2017	Co(II)-Doped Cd-MOF as an Efficient Water Oxidation Catalyst: Doubly Interpenetrated Boron Nitride Network with the Encapsulation of Free Ligand Containing Pyridine Moieties.	Water	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
29071365-8	2017	The proposed analytical method was applied to the analysis of surface water samples, containing concentrations of these contaminants ranging from 100 ng L-1 to 2 mug L-1.	Water	70-75	L1 cell adhesion molecule	Homo sapiens	153-161
29061827-13	2017	The undisturbed water molecule present in distal heme cavity of the LPO is expected to facilitate the oxidation and activation of the three heterocyclic amines.	Water	16-21	lactoperoxidase	Homo sapiens	68-71
28882369-3	2017	METHODS: The paste, composed of (VEGF-loaded PLGA)-containing gelatin/alginate/beta-TCP in water, was loaded into standard Nordson cartridges and promptly employed for printing the scaffolds.	Water	91-96	vascular endothelial growth factor A	Homo sapiens	33-37
28728382-16	2017	Both 1 mug/mL and 5 mug/mL of TCMF water extraction increased MyHC IIa, MyHC IIb, and MyHC IIx mRNA expression in porcine myocytes (p&lt;0.05), while MyHC I mRNA expression in porcine myocytes was decreased by 5 mug/mL TCMF water extraction (p&lt;0.05).	Water	35-40	myosin-1	Sus scrofa	86-94
28388001-4	2017	Stable direct and water-mediated hydrogen bonds were observed between guide RNA backbone atoms and hAgo2, especially for nucleotides 2-7.	Water	18-23	argonaute RISC catalytic component 2	Homo sapiens	99-104
28388001-5	2017	In addition, water-mediated hydrogen bonds are indicated to be critical in the specific recognition between hAgo2 and the conserved adenine in position 1 of target RNA.	Water	13-18	argonaute RISC catalytic component 2	Homo sapiens	108-113
28818782-3	2017	Atom transfer radical polymerization (ATRP) initiator functionalized MSN (MSN-Br) was synthesized at first, which was followed by surface-initiated ATRP of water soluble OEGMA and carboxyl-containing monomer (2-succinyloxyethyl methacrylate, SEMA).	Water	156-161	moesin	Homo sapiens	69-72
28818782-3	2017	Atom transfer radical polymerization (ATRP) initiator functionalized MSN (MSN-Br) was synthesized at first, which was followed by surface-initiated ATRP of water soluble OEGMA and carboxyl-containing monomer (2-succinyloxyethyl methacrylate, SEMA).	Water	156-161	moesin	Homo sapiens	74-80
28818782-3	2017	Atom transfer radical polymerization (ATRP) initiator functionalized MSN (MSN-Br) was synthesized at first, which was followed by surface-initiated ATRP of water soluble OEGMA and carboxyl-containing monomer (2-succinyloxyethyl methacrylate, SEMA).	Water	156-161	semaphorin 3B	Homo sapiens	242-246
31966420-6	2017	More importantly, 9-cis-RA treatment could reduce the apoptotic rate of neurons caused by H2O2 or Abeta stimulation via enhancing the expression level of Bcl-2 protein.	Water	90-94	BCL2 apoptosis regulator	Homo sapiens	154-159
28714073-11	2017	Our recent findings demonstrate that body weight influences Ang II-stimulated water intake in certain conditions in male, but not in female rats.	Water	78-83	angiotensinogen	Rattus norvegicus	60-66
28714073-12	2017	When differences in body weight are corrected for in the appropriate circumstances, we found that males consume more water in response to Ang II compared with females.	Water	117-122	angiotensinogen	Rattus norvegicus	138-144
28874461-5	2017	Dehydration promoted increased water intake in Ren-bNull mice, particularly after deoxycorticosterone acetate-salt.	Water	31-36	renin 1 structural	Mus musculus	47-50
28936578-7	2017	Transformations of water chemistry in "urban" caves, often centuries old, manifest themselves in, inter alia, the occurrence of multi-ionic waters, including seasonal variations and extremely diversified concentrations, with very high concentrations in subpopulations of NO3 (0.2-485 mg dm-3) and P (0.02-6.87 mg dm-3).	Water	19-24	NBL1, DAN family BMP antagonist	Homo sapiens	271-274
29035021-2	2017	The entire water column experiences sulfidic (~50 muM) conditions seasonally, resulting in a system poised between oxic and sulfidic conditions.	Water	11-16	latexin	Homo sapiens	50-53
27977866-10	2017	Groups with flow rates at 1 and 0.5 mL min-1 had a significantly lower temperature rise when compared to the group without water flow (P &lt; 0.001).	Water	123-128	CD59 molecule (CD59 blood group)	Homo sapiens	39-44
29211290-11	2017	This study revealed higher expression of ALP and mineralization in cells exposed to MTA mixed with water and MTA mixed with MC/CaCl2 compared to the control (p&lt;.05).	Water	99-104	alkaline phosphatase, placental	Homo sapiens	41-44
29027456-5	2017	By employing first-principles density functional theory calculations, we find that pseudohalogen (CN and OCN) passivated PNRs not only show desired VBM and CBM band edge positions induced by edge electric dipole layer, but also possess intrinsic optoelectronic properties of phosphorene, for both water oxidation and hydrogen reduction in photocatalytic water splitting without using extra energy.	Water	297-302	bone gamma-carboxyglutamate protein	Homo sapiens	105-108
29027456-5	2017	By employing first-principles density functional theory calculations, we find that pseudohalogen (CN and OCN) passivated PNRs not only show desired VBM and CBM band edge positions induced by edge electric dipole layer, but also possess intrinsic optoelectronic properties of phosphorene, for both water oxidation and hydrogen reduction in photocatalytic water splitting without using extra energy.	Water	354-359	bone gamma-carboxyglutamate protein	Homo sapiens	105-108
28976750-4	2017	Arctii Fructus water extract (AFW) or ethanol extract (AFE) and ARC reduced the production of histamine and pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-6, IL-8, and TNF-alpha in mast cells.	Water	15-20	interleukin 6	Mus musculus	167-171
28976750-4	2017	Arctii Fructus water extract (AFW) or ethanol extract (AFE) and ARC reduced the production of histamine and pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-6, IL-8, and TNF-alpha in mast cells.	Water	15-20	tumor necrosis factor	Mus musculus	183-192
29903197-27	2017	Compared with those of the mice with pure water, significant decrease in IL-6(( 201.	Water	42-47	interleukin 6	Mus musculus	73-77
29492090-1	2017	Background &amp; Objective: Catalase (CAT) is an important endogenous antioxidant enzyme that detoxifies H2O2 into water and oxygen, consequently limiting the deleterious effects of reactive oxygen species.	Water	115-120	catalase	Homo sapiens	28-36
29492090-1	2017	Background &amp; Objective: Catalase (CAT) is an important endogenous antioxidant enzyme that detoxifies H2O2 into water and oxygen, consequently limiting the deleterious effects of reactive oxygen species.	Water	115-120	catalase	Homo sapiens	38-41
29036389-4	2017	High radon activity (180 Bq l-1) was also found in thermal potable water in fountains used by the patients and the public.	Water	67-72	immunoglobulin kappa variable 1-16	Homo sapiens	28-31
28357978-0	2017	Monochloramine Loss Mechanisms in Tap Water.	Water	38-43	SEC14 like lipid binding 2	Homo sapiens	34-37
28357978-3	2017	In tap water, the NH2Cl loss rate can be influenced by temperature, pH, Cl/N molar ratio, the initial NH2Cl concentration, and the natural organic matter (NOM) concentration.	Water	7-12	SEC14 like lipid binding 2	Homo sapiens	3-6
28357978-5	2017	In this research, a kinetic rate constant &lt;inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="01999-ilm01.gif"/&gt;)and a reactive site fraction (S = 0.43 +- 0.06) for the reaction between free chlorine released from NH2Cl autodecoposition and tap water NOM were derived from a kinetic model to predict the NH2Cl loss under various conditions.	Water	270-275	SEC14 like lipid binding 2	Homo sapiens	266-269
28672263-7	2017	The SPI nanoaggregates were used to prepare oil-in-water nanoemulsions with canola oil, which exhibited good stability over 21days at 4 C. In addition, the pH 12-MTS samples had resulted in the highest protein solubility, lowest turbidity, free sulfhydryl and disulfide bonds, surface hydrophobicity, antioxidant activity, and rheological and emulsifying properties than the other samples.	Water	51-56	chromogranin A	Homo sapiens	4-7
28844113-1	2017	In this proof-of-concept study, the efficacy of a medium-pressure UV (MPUV) lamp source to reduce the concentrations of aflatoxin B1, aflatoxin B2, and aflatoxin G1 (AFB1, AFB2, and AFG1) in pure water is investigated.	Water	196-201	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	130-164
29111814-2	2017	Here, we report an activation of ATM/ATR-dependent signaling pathway also as a mechanism for the cancer cell growth inhibition induced by the supernatant fraction of the water-soluble extract from sarsaparilla (SW).	Water	170-175	ATR serine/threonine kinase	Homo sapiens	37-40
28738634-5	2017	Detection limits were in the 5-50 and 15-250ngL-1 ranges for water and urine samples, respectively.	Water	61-66	leucine rich repeat containing 4C	Homo sapiens	44-49
28902994-4	2017	This work led to the identification of compound 40, a potent and selective mGluR4 positive allosteric modulator (PAM) with good water solubility and demonstrating consistent activity across validated preclinical rodent models of PD motor symptoms after intraperitoneal administration: haloperidol-induced catalepsy in mouse and the rat 6-hydroxydopamine (6-OHDA) lesion model.	Water	128-133	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	75-81
29088069-0	2017	Refined Deep-Sea Water Suppresses Inflammatory Responses via the MAPK/AP-1 and NF-kappaB Signaling Pathway in LPS-Treated RAW 264.7 Macrophage Cells.	Water	17-22	mitogen-activated protein kinase 1	Mus musculus	65-69
28945089-9	2017	The dissociation of HNO3 to NO3- in the presence of additional water results in an intense NO3- symmetric stretching UVRR band at 1044 cm-1.	Water	63-68	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
28793774-6	2017	The phase diagram obtained in this work, which is found to be consistent with previous simulation studies, is close to its experimental counterpart provided the TIP4P/Ice model is used to describe the water molecule.	Water	201-206	carboxylesterase 2	Homo sapiens	167-170
29073266-11	2017	The percentage of breaths with PIP&gt;35 cm H2O was 19.5% (SD 32.8%) at t1 and 39.2% (SD 37.7%) at t2 (padj = 0.27; beta = +0.61, SE = 0.36) and significantly decreased (padj = 0.01; beta = -1.61, SE = 0.55) to 6.0% (SD 15.4%) at t3.	Water	44-47	prolactin induced protein	Homo sapiens	31-34
28960056-5	2017	It contains two opposite functional groups (perfluoropolyether segments and amidic groups) (SC2-PFPE) that provide water repellency while hydrophilicity is retained.	Water	115-120	trans-2,3-enoyl-CoA reductase	Homo sapiens	92-95
28984335-0	2017	The design of synthetic superoxide dismutase mimetics: seven-coordinate water soluble manganese(ii) and iron(ii) complexes and their superoxide dismutase-like activity studies.	Water	72-77	superoxide dismutase 1	Homo sapiens	24-44
28945089-9	2017	The dissociation of HNO3 to NO3- in the presence of additional water results in an intense NO3- symmetric stretching UVRR band at 1044 cm-1.	Water	63-68	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
29965190-3	2017	The water-soluble ions were characterized by the highest concentrations of SO42- and NO3-, followed by Na+ and NH4+.	Water	4-9	NBL1, DAN family BMP antagonist	Homo sapiens	85-88
28651083-3	2017	Further evaluation was carried out (1) to compare the potential for DBP formation upon chlorination of treated water, (2) to determine the biostability that might result from minimizing assimilable organic carbon (AOC), and (3) to use laboratory-scale soil-column experiments to compare the effects of removal of trace organic chemicals (TOrCs) between managed aquifer recharge (MAR) hybrid systems (such as bank filtration followed by artificial recharge and recovery: ARR), and ozonation followed by ARR.	Water	111-116	D-box binding PAR bZIP transcription factor	Homo sapiens	68-71
28994710-8	2017	RD2 and D3D3, both derived from D3 by rational design, were discovered to be the most effective derivatives in improving cognition in the Morris water maze.	Water	145-150	peripherin 2	Mus musculus	0-3
28994710-9	2017	The performance of RD2- and D3D3-treated mice within the Morris water maze was significantly better than placebo-treated mice and, importantly, nearly as good as those of non-transgenic littermates, suggesting a complete reversal of the cognitive deficit of APPSL mice.	Water	64-69	peripherin 2	Mus musculus	19-22
28807355-11	2017	Moreover, treatment with H2-rich water decreased the levels of oxidative DNA damage markers such as phosphorylated histone H2AX and 8-hydroxy-2"-deoxyguanosine, and senescence markers such as cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase inhibitor 1, and beta-galactosidase in the CS-exposed mice.	Water	33-38	cyclin dependent kinase inhibitor 2A	Mus musculus	192-265
29375966-4	2018	These photocathodes with subsequent deposition of Pt nanoparticles generate a photovoltage of 300 mV and a photocurrent density of 2.4 mA cm-2 at 0 V versus reversible hydrogen electrode (RHE) for water splitting under simulated visible-light illumination (lambda &gt; 500 nm, Pin = 80 mW cm-2).	Water	197-202	dynein light chain LC8-type 1	Homo sapiens	277-280
28951921-2	2017	It was found that because the water molecules respond to electric field, the nano-droplet elongates in the field direction for a field amplitude larger than 0.08 V A-1, which is stronger than the predicted value from the Young-Laplace equation.	Water	30-35	BCL2 related protein A1	Homo sapiens	164-167
28872861-2	2017	It is widely suggested that SP-B1-25-induced lipid polymorphisms within the alveolar aqueous subphase provide a structural platform for rapid lipid adsorption to the air-water interface.	Water	170-175	FtsJ RNA 2'-O-methyltransferase 1	Homo sapiens	28-33
28986587-0	2017	The drinking water contaminant dibromoacetonitrile delays G1-S transition and suppresses Chk1 activation at broken replication forks.	Water	13-18	checkpoint kinase 1	Homo sapiens	89-93
28936519-1	2017	Fog collection is receiving increasing attention for providing water in semi-arid deserts and inland areas.	Water	63-68	zinc finger protein, FOG family member 1	Homo sapiens	0-3
28446807-8	2017	Twenty-four-hour water intake and urine volume were significantly higher in the nesf/NUCB2-Tg mice than in their non-Tg littermates.	Water	17-22	nucleobindin 2	Mus musculus	85-90
28937227-5	2017	I present here high-resolution elastic neutron scattering measurements of the atomistic dynamics of lysozyme in water.	Water	112-117	lysozyme	Homo sapiens	100-108
28898581-0	2017	Trapping and Structural Characterization of the XNO2 NO3- (X = Cl, Br, I) Exit Channel Complexes in the Water-Mediated X- + N2O5 Reactions with Cryogenic Vibrational Spectroscopy.	Water	104-109	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
28898581-1	2017	The heterogeneous reaction of N2O5 with sea spray aerosols yields the ClNO2 molecule, which is postulated to occur through water-mediated charge separation into NO3- and NO2+ ions followed by association with Cl-.	Water	123-128	NBL1, DAN family BMP antagonist	Homo sapiens	161-164
28871779-2	2017	Upon the action of caspase-3, the water-soluble fluorescent probe Ac-DEVD-NH-CV, which is weakly green emissive in aqueous solution, is converted to hydrophobic CV-NH2, which spontaneously aggregates.	Water	34-39	caspase 3	Homo sapiens	19-28
28829147-9	2017	The DeltaDeltaG value is a critical factor in evaluating whether a poorly water-soluble drug can be solubilized by L-PGDS.	Water	74-79	prostaglandin D2 synthase	Homo sapiens	115-121
28920977-5	2017	In order to further improve the detonation performance, using [Cu(Htztr)2(H2O)2]n as a precursor, {[Cu(Htztr)(H2O)]NO3}n (1) and [Cu(H2tztr)2(HCOO)2]n (2) were synthesized by the axial substitution reaction with NO3- and HCOO-.	Water	74-77	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
28489967-5	2017	SERPING1 was also statistically significantly associated with water holding capacity (p &lt; 0.05), which is closely associated with postmortem pH.	Water	62-67	serpin family G member 1	Sus scrofa	0-8
28767284-10	2017	The World Health Organization AFP 72/225 reference material diluted with distilled water was also commutable at high concentrations.	Water	83-88	alpha fetoprotein	Homo sapiens	30-33
28734214-4	2017	Mean concentrations of total Hg (THg) and methylmercury (MeHg) in river water in WRB were 3.41 +- 1.98 ng L-1 and 0.15 +- 0.06 ng L-1, respectively.	Water	72-77	immunoglobulin kappa variable 1-16	Homo sapiens	106-109
28829143-2	2017	NADP(H) quinone oxidoreductase 1 (NQO1) inhibitors, such as beta-lapachone (LPC) and tanshinone IIA (THA), are structurally and pharmacologically similar molecules that are poorly water-soluble, crystallize extremely fast, and demonstrate synergistic anticancer effect when used together with paclitaxel (PTX).	Water	180-185	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-32
28829143-2	2017	NADP(H) quinone oxidoreductase 1 (NQO1) inhibitors, such as beta-lapachone (LPC) and tanshinone IIA (THA), are structurally and pharmacologically similar molecules that are poorly water-soluble, crystallize extremely fast, and demonstrate synergistic anticancer effect when used together with paclitaxel (PTX).	Water	180-185	NAD(P)H quinone dehydrogenase 1	Homo sapiens	34-38
28829147-0	2017	Comprehensive Evaluation of the Binding of Lipocalin-Type Prostaglandin D Synthase to Poorly Water-Soluble Drugs.	Water	93-98	prostaglandin D2 synthase	Homo sapiens	43-82
28829147-2	2017	We developed a novel drug delivery system (DDS) for poorly water-soluble drugs using lipocalin-type prostaglandin D synthase (L-PGDS), which belongs to the lipocalin superfamily and binds a large variety of hydrophobic molecules.	Water	59-64	prostaglandin D2 synthase	Homo sapiens	85-124
28829147-2	2017	We developed a novel drug delivery system (DDS) for poorly water-soluble drugs using lipocalin-type prostaglandin D synthase (L-PGDS), which belongs to the lipocalin superfamily and binds a large variety of hydrophobic molecules.	Water	59-64	prostaglandin D2 synthase	Homo sapiens	126-132
28829147-3	2017	In this study, we comprehensively evaluated the capability of L-PGDS to bind and solubilize various poorly water-soluble drugs using structure-based docking.	Water	107-112	prostaglandin D2 synthase	Homo sapiens	62-68
28815448-7	2017	Here we report backbone and sidechain 1H, 13C and 15N chemical shift assignments of TRADD DD in pure water as a basis for further structural and functional studies.	Water	101-106	TNFRSF1A associated via death domain	Homo sapiens	84-89
28609662-0	2017	Development of bovine serum albumin-water partition coefficients predictive models for ionogenic organic chemicals based on chemical form adjusted descriptors.	Water	36-41	albumin	Homo sapiens	22-35
28601007-10	2017	Strikingly high concentrations of total I-THMs were observed in the finished water (2848 ng L-1 in conventional DWTP and 356 ng L-1 in advanced DWTP).	Water	77-82	L1 cell adhesion molecule	Homo sapiens	92-95
28651318-3	2017	The total concentrations of seven dissolved PAHs in surface water ranged from 1.0 to 5.1 ng L-1, decreasing with increasing latitude.	Water	60-65	immunoglobulin kappa variable 1-16	Homo sapiens	92-95
28111811-4	2017	Combining imiquimod with detergent-containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP3 or AQP3 and AQP10.	Water	46-51	aquaporin 3	Mus musculus	171-175
28689149-9	2017	Tightly coupled decreasing trends in stream-water silicon (Si) (-0.2 mueq L-1 yr-1) and base cations suggest a decrease in the soil mineral weathering rate.	Water	44-49	L1 cell adhesion molecule	Homo sapiens	74-82
28111811-4	2017	Combining imiquimod with detergent-containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP3 or AQP3 and AQP10.	Water	46-51	aquaporin 3	Mus musculus	179-183
28596233-0	2017	Adaptable interaction between aquaporin-1 and band 3 reveals a potential role of water channel in blood CO2 transport.	Water	81-86	aquaporin 1 (Colton blood group)	Homo sapiens	30-41
28596233-8	2017	By demonstrating AQP1 as a mobile component of the CO2 transport metabolon, our results uncover a potential role of water channel in blood CO2 transport and respiration.-Hsu, K., Lee, T.-Y., Periasamy, A., Kao, F.-J., Li, L.-T., Lin, C.-Y., Lin, H.-J., Lin, M. Adaptable interaction between aquaporin-1 and band 3 reveals a potential role of water channel in blood CO2 transport.	Water	116-121	aquaporin 1 (Colton blood group)	Homo sapiens	17-21
28596233-8	2017	By demonstrating AQP1 as a mobile component of the CO2 transport metabolon, our results uncover a potential role of water channel in blood CO2 transport and respiration.-Hsu, K., Lee, T.-Y., Periasamy, A., Kao, F.-J., Li, L.-T., Lin, C.-Y., Lin, H.-J., Lin, M. Adaptable interaction between aquaporin-1 and band 3 reveals a potential role of water channel in blood CO2 transport.	Water	116-121	aquaporin 1 (Colton blood group)	Homo sapiens	291-302
28596233-8	2017	By demonstrating AQP1 as a mobile component of the CO2 transport metabolon, our results uncover a potential role of water channel in blood CO2 transport and respiration.-Hsu, K., Lee, T.-Y., Periasamy, A., Kao, F.-J., Li, L.-T., Lin, C.-Y., Lin, H.-J., Lin, M. Adaptable interaction between aquaporin-1 and band 3 reveals a potential role of water channel in blood CO2 transport.	Water	342-347	aquaporin 1 (Colton blood group)	Homo sapiens	17-21
28586472-9	2017	Per-serving-per-day substitution of ASBs with water during pregnancy was related to a lower overweight/obesity risk at 7 years (aRR 0.83; 95% CI: 0.76, 0.91), whereas SSB substitution with ASBs was not related to a lower risk (aRR 1.14; 95% CI: 1.00, 1.31).	Water	46-51	arrestin beta 1	Homo sapiens	227-232
28554793-5	2017	The first formation equilibrium constants were calculated as Kf1: 5.48x103 1/M for Na(I)-insulin complex and Kf1: 4.87x103 1/M for K(I)-insulin in water.	Water	147-152	insulin	Homo sapiens	89-96
28554793-5	2017	The first formation equilibrium constants were calculated as Kf1: 5.48x103 1/M for Na(I)-insulin complex and Kf1: 4.87x103 1/M for K(I)-insulin in water.	Water	147-152	insulin	Homo sapiens	136-143
28554793-7	2017	In case of a comparison together with Ca(II)-insulin and Mg(II)-insulin, the formation equilibrium constants (Kf1) are in order of Ca(II)-insulin&gt;Mg(II)-insulin&gt;Na(I)-insulin&gt;K(I)-insulin in water.	Water	200-205	insulin	Homo sapiens	45-52
28554793-7	2017	In case of a comparison together with Ca(II)-insulin and Mg(II)-insulin, the formation equilibrium constants (Kf1) are in order of Ca(II)-insulin&gt;Mg(II)-insulin&gt;Na(I)-insulin&gt;K(I)-insulin in water.	Water	200-205	insulin	Homo sapiens	64-71
28554793-7	2017	In case of a comparison together with Ca(II)-insulin and Mg(II)-insulin, the formation equilibrium constants (Kf1) are in order of Ca(II)-insulin&gt;Mg(II)-insulin&gt;Na(I)-insulin&gt;K(I)-insulin in water.	Water	200-205	insulin	Homo sapiens	64-71
28554793-7	2017	In case of a comparison together with Ca(II)-insulin and Mg(II)-insulin, the formation equilibrium constants (Kf1) are in order of Ca(II)-insulin&gt;Mg(II)-insulin&gt;Na(I)-insulin&gt;K(I)-insulin in water.	Water	200-205	insulin	Homo sapiens	64-71
28726316-3	2017	Structural data indicate that two active site water molecules, one bridging the two Mn2+ ions and the other terminally coordinated with one of the Mn2+ ions (Mn1), are involved in catalysis.	Water	46-51	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	158-161
28283795-8	2017	Moreover, when transferred to hyposmotic media (fresh water) from seawater, parallel increases in branchial mRNA and protein expression of NKA alpha1 and beta1 subunits suggested their roles in hypo-osmoregulation of euryhaline milkfish.	Water	54-59	tachykinin precursor 1	Homo sapiens	139-142
27709492-9	2017	However, C5aR-/- mice exhibited significant attenuation of inflammatory reaction, accompanied by a remarkable reduction of Fgl-2, brain water content, and neurological dysfunction.	Water	136-141	complement component 5a receptor 1	Mus musculus	9-13
28937782-13	2017	CONCLUSIONS:   With cold-water immersion, the cooling rate in CCs (0.255 C min-1) was greater than in FBs (0.156 C min-1); however, both were considered ideal (&gt;=0.155 C min-1).	Water	25-30	CD59 molecule (CD59 blood group)	Homo sapiens	75-80
28992804-8	2017	Grafting hyaluronic acid to the poly(2-hydroxyethyl methacrylate) surfaces decreased the contact angle, the dehydration rate, and the amount of nonspecific sorption of lysozyme and albumin in comparison to pristine hydrogel materials, suggesting the development of more wettable surfaces with improved water-retentive and antifouling properties, while maintaining optical transparency (&gt;92%).	Water	302-307	albumin	Homo sapiens	181-188
28649750-1	2017	Vasopressin (AVP) plays a major role in the regulation of water and sodium homeostasis by its antidiuretic action on the kidney, mediated by V2 receptors.	Water	58-63	arginine vasopressin	Homo sapiens	0-11
28649750-1	2017	Vasopressin (AVP) plays a major role in the regulation of water and sodium homeostasis by its antidiuretic action on the kidney, mediated by V2 receptors.	Water	58-63	arginine vasopressin	Homo sapiens	13-16
28687177-0	2017	Associative learning contributes to the increased water intake observed after daily injections of angiotensin II.	Water	50-55	angiotensinogen	Rattus norvegicus	98-112
28687177-1	2017	Daily injections of angiotensin II (AngII) cause a progressive increase of water intake that resembles a classically ascribed non-associative sensitization.	Water	75-80	angiotensinogen	Rattus norvegicus	20-34
28687177-1	2017	Daily injections of angiotensin II (AngII) cause a progressive increase of water intake that resembles a classically ascribed non-associative sensitization.	Water	75-80	angiotensinogen	Rattus norvegicus	36-41
28687177-3	2017	To test this hypothesis, and remove the influence of drinking itself, we implemented a delay in water access after injection of AngII (icv) on four consecutive "induction days," and then measured intake on the next day ("test day") when rats were allowed to drink immediately after AngII.	Water	96-101	angiotensinogen	Rattus norvegicus	128-133
28687177-6	2017	Taken together, these findings suggest that the increased drinking observed after daily injections of AngII is a conditioned appetition after repeated pairings of AngII and water intake.	Water	173-178	angiotensinogen	Rattus norvegicus	102-107
29183231-1	2017	The cytochrome P450 (CYP) enzyme superfamily is involved in phase I metabolism which chemically modifies a variety of substrates via oxidative reactions to make them more water-soluble and easier to eliminate.	Water	171-176	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-19
29183231-1	2017	The cytochrome P450 (CYP) enzyme superfamily is involved in phase I metabolism which chemically modifies a variety of substrates via oxidative reactions to make them more water-soluble and easier to eliminate.	Water	171-176	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-24
28863242-2	2017	The coated fabrics show superphobic to both water and oil fluids (surface tension &gt;21.5 mN m-1 ).	Water	44-49	myoregulin	Homo sapiens	94-97
28956841-9	2017	The rain erosion performance is assessed using an accelerated testing technique, whereby the test material is repeatedly impacted at high speed with water droplets in a Whirling Arm Rain Erosion Rig (WARER).	Water	149-154	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	195-198
28614742-11	2017	This study shows that binding with amino nitrogen compounds should be an important process for HBQs transformation and detoxification, which helps to better understand the fate of this typical DBP in surface water.	Water	208-213	D-box binding PAR bZIP transcription factor	Homo sapiens	193-196
30023750-1	2017	The binding interaction of a biocompatible water-soluble polycationic two-photon fluorophore (Ant-PIm) toward human serum albumin (HSA) was thoroughly investigated under simulated physiological conditions using a combination of steady-state, time-resolved, and two-photon excited fluorescence techniques.	Water	43-48	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	98-101
30023750-1	2017	The binding interaction of a biocompatible water-soluble polycationic two-photon fluorophore (Ant-PIm) toward human serum albumin (HSA) was thoroughly investigated under simulated physiological conditions using a combination of steady-state, time-resolved, and two-photon excited fluorescence techniques.	Water	43-48	albumin	Homo sapiens	116-135
28884777-1	2017	This work demonstrates that a single Ru atom-modified covalent triazine framework (Ru-CTF) has selectivity for the electrooxidation of benzyl alcohol in water over the oxygen evolution reaction.	Water	153-158	nuclear factor I C	Homo sapiens	86-89
28894006-4	2017	We show that the protein within the concentrated phase of phase-separated Ddx4, [Formula: see text], diffuses as a particle of 600-nm hydrodynamic radius dissolved in water.	Water	167-172	DEAD-box helicase 4	Homo sapiens	74-78
28783296-1	2017	The origin of the dissolution of methylammonium lead trihalide (MAPI) crystals in liquid water is clarified by finite-temperature molecular dynamics by developing a MYP-based force field (MYP1) for water-MAPI systems.	Water	89-94	Myopia, X-linked (Bornholm eye disease)	Homo sapiens	188-192
28783296-1	2017	The origin of the dissolution of methylammonium lead trihalide (MAPI) crystals in liquid water is clarified by finite-temperature molecular dynamics by developing a MYP-based force field (MYP1) for water-MAPI systems.	Water	198-203	Myopia, X-linked (Bornholm eye disease)	Homo sapiens	188-192
28009908-3	2017	Oxidative stress response assays have proven to be sensitive tools, but the mechanism by which water samples are inducing the oxidative stress response remains unclear because both electrophiles and reactive oxygen species (ROS) may activate the Nrf2-antioxidant response element (ARE) pathway.	Water	95-100	NFE2 like bZIP transcription factor 2	Homo sapiens	246-250
28935920-6	2017	The results showed that BAY reversed Abeta-induced cognitive impairment as shown in the water maze test and step-down test.	Water	88-93	amyloid beta precursor protein	Homo sapiens	37-42
28809537-14	2017	From simulations using a variety of water models, we demonstrate that the relatively simple SPC/E water model yields results in close agreement with those obtained from polarizable water models.	Water	36-41	proline rich protein gene cluster	Homo sapiens	92-95
28581632-1	2017	In view of their promising bio-applicability, we have synthesized water-soluble bovine serum albumin (BSA)-encapsulated ZnSe quantum dots (QDs) with visible emission with longer average luminescence lifetimes of approximately 125 ns at ambient conditions.	Water	66-71	albumin	Homo sapiens	87-100
28857104-5	2017	Unconstrained molecular dynamics simulation of 50 molecules of TNS with the native state of BSA, native and two partially unfolded states of RNase A and alpha-lactalbumin in water was carried out.	Water	174-179	lactalbumin alpha	Homo sapiens	153-170
28784926-4	2017	The cystic fibrosis transmembrane conductance regulator (CFTR) plays the main role in water flux in the intestine, and it is closely associated with bacterial clearance.	Water	86-91	CF transmembrane conductance regulator	Homo sapiens	57-61
28809537-14	2017	From simulations using a variety of water models, we demonstrate that the relatively simple SPC/E water model yields results in close agreement with those obtained from polarizable water models.	Water	98-103	proline rich protein gene cluster	Homo sapiens	92-95
28809537-14	2017	From simulations using a variety of water models, we demonstrate that the relatively simple SPC/E water model yields results in close agreement with those obtained from polarizable water models.	Water	98-103	proline rich protein gene cluster	Homo sapiens	92-95
28806517-0	2017	From Nonluminescent Cs4PbX6 (X = Cl, Br, I) Nanocrystals to Highly Luminescent CsPbX3 Nanocrystals: Water-Triggered Transformation through a CsX-Stripping Mechanism.	Water	100-105	NK2 homeobox 5	Homo sapiens	141-144
28862848-0	2017	Enantioselective Aldol Reactions in Water by a Proline-Derived Cryptand and Fixation of CO2 by Its Exocyclic Co(II) Complex.	Water	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
28836758-6	2017	We found that, for controlled in vitro culture at water-PFC interfaces, expression of myogenin, myogenic regulatory factors (MRF) family gene, is remarkably attenuated even when myogenic differentiation was induced by reducing levels of growth factors, although MyoD was expressed at the usual level (MyoD up-regulates myogenin under an elastic and/or viscoelastic environment).	Water	50-55	myogenic differentiation 1	Homo sapiens	262-266
28836758-6	2017	We found that, for controlled in vitro culture at water-PFC interfaces, expression of myogenin, myogenic regulatory factors (MRF) family gene, is remarkably attenuated even when myogenic differentiation was induced by reducing levels of growth factors, although MyoD was expressed at the usual level (MyoD up-regulates myogenin under an elastic and/or viscoelastic environment).	Water	50-55	myogenic differentiation 1	Homo sapiens	301-305
28806517-2	2017	During the transformation, Cs4PbX6 NCs dispersed in a nonpolar solvent are converted into CsPbX3 NCs by stripping CsX through an interfacial reaction with water in a different phase.	Water	155-160	NK2 homeobox 5	Homo sapiens	114-117
28806517-3	2017	This process takes advantage of the high solubility of CsX in water as well as the ionic nature and high ion diffusion property of Cs4PbX6 NCs, and produces monodisperse and air-stable CsPbX3 NCs with controllable halide composition, tunable emission wavelength covering the full visible range, narrow emission width, and high photoluminescent quantum yield (up to 75%).	Water	62-67	NK2 homeobox 5	Homo sapiens	55-58
28806517-4	2017	An additional advantage is that this is a clean synthesis as Cs4PbX6 NCs are converted into CsPbX3 NCs in the nonpolar phase while the byproduct of CsX is formed in water that could be easily separated from the organic phase.	Water	165-170	NK2 homeobox 5	Homo sapiens	148-151
28902165-4	2017	Besides, this simplification significantly enhanced water solubility and membrane permeability, indicating that these compounds are more favourable for the further development of therapeutic agents around Nrf2 activation.	Water	52-57	NFE2 like bZIP transcription factor 2	Homo sapiens	205-209
28586724-0	2017	Sub-1min separation in sequential injection chromatography for determination of synthetic water-soluble dyes in pharmaceutical formulation.	Water	90-95	SUB1 regulator of transcription	Homo sapiens	0-5
28727426-9	2017	Our findings reveal an extraordinary ability of Abeta oligomers to form pores in pure water prior to their insertion into a membrane and thus provide support to the ion channel hypothesis of AD.	Water	86-91	amyloid beta precursor protein	Homo sapiens	48-53
28792750-4	2017	The updated mechanism was first used to reproduce CO, CO2, and H2O concentration time histories during EF pyrolysis in the shock tube reported by Ren et al.	Water	63-66	renin	Homo sapiens	146-149
28586724-3	2017	In this paper, a sub-1min separation using medium polar cyano monolithic column (5mmx4.6mm) resulted in fast and green separation with sample throughput comparable with non-separation flow methods The separation of three synthetic water-soluble dyes (sunset yellow FCF, carmoisine and green S) was in a gradient elution mode (0.02% ammonium acetate, pH 6.7 - water) with flow rate of 3.0mLmin-1 corresponding with sample throughput of 30h-1.	Water	231-236	SUB1 regulator of transcription	Homo sapiens	17-22
28586724-3	2017	In this paper, a sub-1min separation using medium polar cyano monolithic column (5mmx4.6mm) resulted in fast and green separation with sample throughput comparable with non-separation flow methods The separation of three synthetic water-soluble dyes (sunset yellow FCF, carmoisine and green S) was in a gradient elution mode (0.02% ammonium acetate, pH 6.7 - water) with flow rate of 3.0mLmin-1 corresponding with sample throughput of 30h-1.	Water	359-364	SUB1 regulator of transcription	Homo sapiens	17-22
28827365-3	2017	The structures reveal that a single catalytic water is involved in both catalytic activities of LTA4H, alternating between epoxide ring opening and peptide bond hydrolysis, assisted by E271 and E296, respectively.	Water	46-51	leukotriene A4 hydrolase	Homo sapiens	96-101
28438322-5	2017	Water suppression homogeneity was moderate-poor in a greater number of cases in set 1.	Water	0-5	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	80-85
28869532-1	2017	The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP- and cGMP-regulated chloride (Cl-) and bicarbonate (HCO3-) channel localized primarily at the apical plasma membrane of epithelial cells lining the airway, gut and exocrine glands, where it is responsible for transepithelial salt and water transport.	Water	307-312	CF transmembrane conductance regulator	Homo sapiens	4-55
28869532-1	2017	The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP- and cGMP-regulated chloride (Cl-) and bicarbonate (HCO3-) channel localized primarily at the apical plasma membrane of epithelial cells lining the airway, gut and exocrine glands, where it is responsible for transepithelial salt and water transport.	Water	307-312	CF transmembrane conductance regulator	Homo sapiens	57-61
28932620-11	2017	The resulting thioester intermediate (INT1) is converted by water attack on the thioester into a second intermediate, a diol (INT2), which is released by proton abstraction by Cys189.	Water	60-65	Wnt family member 1	Homo sapiens	38-42
28715873-0	2017	Subcritical water-hydrolyzed fish collagen ameliorates survival of endotoxemic mice by inhibiting HMGB1 release in a HO-1-dependent manner.	Water	12-17	heme oxygenase 1	Mus musculus	117-121
28743508-9	2017	Good ATX inhibitory activity of 21 was attributed to the hydrogen bonding interactions with Asn230, Trp275 and active site water molecules; electrostatic interaction with catalytic zinc ion and hydrophobic interactions with amino acids of the hydrophobic pocket.	Water	123-128	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	5-8
28500969-6	2017	For fresh water, marine culture water and sea water, the reaction rate constant was 0.066 min-1, 0.466 min-1 and 1.241 min-1, respectively.	Water	10-15	CD59 molecule (CD59 blood group)	Homo sapiens	103-114
28752953-4	2017	Despite their abundance in marine and fresh-water systems, the presence of functional rhodopsin systems in edaphic habitats has never been reported.	Water	44-49	rhodopsin	Homo sapiens	86-95
27804788-5	2017	The composite was further applied for the removal of As(III) and As(V) from water in a dynamic flow through the reactor.	Water	76-81	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-70
28377238-8	2017	Also, water molecules can bridge between the ligand and protein by hydrogen bonds, which are stable during the entire simulation and play an important role in stabilization of the GL/GA-BSA complexes.	Water	6-11	albumin	Homo sapiens	186-189
28450247-7	2017	The hydrophobic properties of the CS films were increased by the addition of LY and REC, determined by water contact angle measurement.	Water	103-108	lysozyme	Homo sapiens	77-79
28572445-5	2017	Use of a water-soluble p38 inhibitor curtailed activation in vivo of MAPKs and Akt in LV CMs as well as the appearance of cytokines and histones in plasma from CLP mice.	Water	9-14	thymoma viral proto-oncogene 1	Mus musculus	79-82
28647778-1	2017	The secondary structure of apolipoprotein B-100 is studied within the bulk phase and at the air/water interface.	Water	96-101	apolipoprotein B	Homo sapiens	27-47
28647778-5	2017	A correlation between the secondary structure of the apoB-100 protein and the monomolecular film elasticity at the air/water interface was also established.	Water	119-124	apolipoprotein B	Homo sapiens	53-61
28599130-1	2017	The interaction between a ruthenium - based water soluble oxygen probe ([Ru(Phen)3]2+, phen - phenanthroline) and human serum albumin (HSA) was investigated with the aim of describing the influence of HSA on the [Ru(Phen)3]2+ luminescence properties.	Water	44-49	albumin	Homo sapiens	120-139
28326667-2	2017	Its clinical efficacy is in principle due to impaired vasopressin-regulated water reabsorption via aquaporin-2 (AQP2).	Water	76-81	arginine vasopressin	Homo sapiens	54-65
28599130-1	2017	The interaction between a ruthenium - based water soluble oxygen probe ([Ru(Phen)3]2+, phen - phenanthroline) and human serum albumin (HSA) was investigated with the aim of describing the influence of HSA on the [Ru(Phen)3]2+ luminescence properties.	Water	44-49	albumin	Homo sapiens	135-138
28735170-4	2017	Therefore, atomistic molecular dynamics (MD) simulations have been carried out to investigate the effect of different solvents (water, urea/water, MeOH and DMSO) on the structure and conformations of apoptotic cyt-c (Fe3+).	Water	128-133	cytochrome c, somatic	Homo sapiens	210-215
28797927-0	2017	Molecular dynamics study of unfolding of lysozyme in water and its mixtures with dimethyl sulfoxide.	Water	53-58	lysozyme	Homo sapiens	41-49
28797927-1	2017	All-atom explicit solvent molecular dynamics was used to study the process of unfolding of hen egg white lysozyme in water and mixtures of water with dimethyl sulfoxide at different compositions.	Water	117-122	lysozyme	Homo sapiens	105-113
28735170-4	2017	Therefore, atomistic molecular dynamics (MD) simulations have been carried out to investigate the effect of different solvents (water, urea/water, MeOH and DMSO) on the structure and conformations of apoptotic cyt-c (Fe3+).	Water	140-145	cytochrome c, somatic	Homo sapiens	210-215
28735170-11	2017	Essential dynamics analysis implies that the overall motions of cyt-c in water, MeOH and urea/water are involved in three to four eigenvectors and in first eigenvector in DMSO.	Water	73-78	cytochrome c, somatic	Homo sapiens	64-69
28735170-11	2017	Essential dynamics analysis implies that the overall motions of cyt-c in water, MeOH and urea/water are involved in three to four eigenvectors and in first eigenvector in DMSO.	Water	94-99	cytochrome c, somatic	Homo sapiens	64-69
28463752-8	2017	In conclusion, proteolytic degradation of myofibrillar proteins by calpain-2, the proteasome or lysosomal enzymes improves the water-holding of myofibrils.	Water	127-132	calpain 2	Homo sapiens	67-76
28552704-7	2017	Results show that intra-VTA sCT reduces water intake in response to central administration of the dipsogenic peptide angiotensin II, but has no effect on ad libitum water intake in the absence of food.	Water	40-45	angiotensinogen	Rattus norvegicus	117-131
28885961-1	2017	BACKGROUND: The procedure of wrapping a heat casualty in ice-water soaked bed sheets to reduce core temperature has received little investigation, despite the practice and recommendation for its use in some military settings.	Water	61-66	carboxylesterase 2	Homo sapiens	57-60
28349346-4	2017	It was shown that illumination of CaCl2-treated PS2 membranes (deprived of the PS2 extrinsic proteins without removal of the Mn-containing water-oxidizing complex) (CaCl2-PS2) led to the photoproduction of highly lipophilic organic hydroperoxides (LP-OOH) (in amount corresponding to 1.5 LP-OOH per one reaction center of PS2) which significantly increased upon the addition of exogenous electron acceptor potassium ferricyanide (to 4.2 LP-OOH per one reaction center).	Water	139-144	taste 2 receptor member 64 pseudogene	Homo sapiens	48-51
27876637-5	2017	Ghrelin injected into either ventricle reduced both water and 1.8% NaCl intake that was stimulated by AngII.	Water	52-57	angiotensinogen	Rattus norvegicus	102-107
28478288-5	2017	In order to remove NO3--N completely from water, Cl- is added to help further oxidize NH4+-N to N2.	Water	42-47	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
28608933-1	2017	Low-level bacterial and endotoxin contamination of water used to generate dialysate propagates chronic inflammation in patients with a wide-range of potential adverse consequences, including erythropoietin hyporesponsiveness.	Water	51-56	erythropoietin	Homo sapiens	191-205
28544090-6	2017	Surprisingly, the pKa value of the catalytic histidine inside the hydrophobic pocket of calmodulin is elevated as compared to the model compound pKa value of this residue in water.	Water	174-179	calmodulin 1	Homo sapiens	88-98
28780863-0	2017	Ambient Conditions and Feeding Strategy Influence delta18O of Milk Water in Cows (Bos taurus).	Water	67-72	Weaning weight-maternal milk	Bos taurus	62-66
30023716-3	2017	The capability of a water-soluble porphyrin, 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin (TMPyP), to inhibit Abeta aggregation and to lower Abeta-induced toxicity was demonstrated.	Water	20-25	amyloid beta precursor protein	Homo sapiens	114-119
28852023-3	2017	The results showed that a dense, robust, and water-resistant adhesive layer was constructed between network-bound catechol moieties in the TAPI and SM system, endowing the STP adhesive with high wet bonding strength for plywood.	Water	45-50	sorbitol-like transporter	Glycine max	172-175
28850173-1	2017	BACKGROUND: Cystic fibrosis is an autosomal recessive inherited defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in abnormal regulation of salt and water movement across the membranes.	Water	187-192	CF transmembrane conductance regulator	Homo sapiens	78-129
28850173-1	2017	BACKGROUND: Cystic fibrosis is an autosomal recessive inherited defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in abnormal regulation of salt and water movement across the membranes.	Water	187-192	CF transmembrane conductance regulator	Homo sapiens	131-135
29745556-1	2017	With the oxidative damage model established in rat myocardial cells by hydrogen peroxide (H 2O 2), the expression of myocardin and nuclear factor erythroid 2-related factor 2 (Nrf2) during oxidative damage and effect of myocardin on Nrf2 were preliminarily explored.	Water	90-94	NFE2 like bZIP transcription factor 2	Rattus norvegicus	176-180
32264423-1	2017	C60@lysozyme showed significant visible light-induced singlet oxygen generation in water, indicating the potential of this hybrid as an agent for photodynamic therapy.	Water	83-88	lysozyme	Homo sapiens	0-12
28766939-5	2017	Here, we present magnetic resonance imaging (MRI) as an accessible and powerful technique to monitor bioreduction by treating the cobalt complex as an MRI contrast agent and monitoring the change in water signal induced by reduction from diamagnetic Co(III) to paramagnetic Co(II).	Water	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	274-280
28821794-7	2017	The fog harvest test showed that the surface with a wedge-shaped pattern array had high water collection efficiency.	Water	88-93	zinc finger protein, FOG family member 1	Homo sapiens	4-7
28830171-2	2017	Earlier it was found that with the united-atom TraPPE model for alkanes and the SPC/E model for water, one had to artificially enhance the attractive alkane-water cross interaction to capture this behavior.	Water	96-101	proline rich protein gene cluster	Homo sapiens	80-83
28830171-2	2017	Earlier it was found that with the united-atom TraPPE model for alkanes and the SPC/E model for water, one had to artificially enhance the attractive alkane-water cross interaction to capture this behavior.	Water	157-162	proline rich protein gene cluster	Homo sapiens	80-83
28782779-2	2017	The reaction in the presence of alcohols gives preferentially vinyltetrahydropyridines with an extra alkoxy group and Pt-H as the active species in the catalytic cycle, while formation of di- and tetrahydroazepines with an extra hydroxyl group is favoured when water is used as nucleophile, via nucleophilic attack/carbocyclization as the favoured pathway.	Water	261-266	parathyroid hormone	Homo sapiens	118-122
28395163-9	2017	Moreover, the fabricated disposable aGO1/SPCE sensor was demonstrated the determination of HQ and CC in tap water and industrial waste water.	Water	108-113	argonaute RISC component 1	Homo sapiens	36-40
28765844-1	2017	In this study, we investigated the effect of [N-(5-chloro-2-hydroxyphenyl)-l-aspartato] chlorogallate (GS2), a new water soluble gallium complex, on cell invasion and on the expression and activity of matrix metalloproteinases (MMPs) in human metastatic HT-1080 fibrosarcoma and MDA-MB 231 breast carcinoma cells.	Water	115-120	patatin like phospholipase domain containing 4	Homo sapiens	103-106
28722398-2	2017	Due to a nascent barrier layer with a loose architecture, the obtained TFC-BDSA-0.2 membrane showed an ultrahigh pure water permeability of 48.1 +- 2.1 L-1 m-2 h-1 bar-1, and a considerably low NaCl retention ability of &lt;1.8% over a concentration range of 10-100 g L-1.	Water	118-123	L1 cell adhesion molecule	Homo sapiens	152-155
28395163-9	2017	Moreover, the fabricated disposable aGO1/SPCE sensor was demonstrated the determination of HQ and CC in tap water and industrial waste water.	Water	135-140	argonaute RISC component 1	Homo sapiens	36-40
28528484-4	2017	Significant positive correlations between PFAS compositions in tap water sample and their source waters were noted.	Water	67-72	phosphoribosylformylglycinamidine synthase	Homo sapiens	42-46
28735547-3	2017	ANF was derived from the copolymerization of terephthaloyl chloride, p-phenylene diamine, and methoxypolyethylene glycol and could be dispersed in water stably.	Water	147-152	natriuretic peptide A	Homo sapiens	0-3
28805732-1	2017	The cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel belongs to the ATP-binding cassette (ABC) transporter superfamily and regulates Cl- secretion in epithelial cells for water secretion.	Water	193-198	CF transmembrane conductance regulator	Homo sapiens	4-55
28805732-1	2017	The cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel belongs to the ATP-binding cassette (ABC) transporter superfamily and regulates Cl- secretion in epithelial cells for water secretion.	Water	193-198	CF transmembrane conductance regulator	Homo sapiens	57-61
28812539-7	2017	Results confirmed that the R137A mutation weakens direct VP24-KPNA5 binding and enables water molecules to penetrate at the interface.	Water	88-93	karyopherin subunit alpha 5	Homo sapiens	62-67
28801577-7	2017	Upon removing the backbone connectivity by breaking all peptide bonds in lysozyme, we find that the hysteresis shifts towards the lower humidity regime, and the water uptake capacity is significantly enhanced.	Water	161-166	lysozyme	Homo sapiens	73-81
28129470-0	2017	The water channel AQP1 is expressed in human atherosclerotic vascular lesions and AQP1 deficiency augments angiotensin II-induced atherosclerosis in mice.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	18-22
28500355-5	2017	The recoveries are between 84.5%-98.6% with the spiked level of 10 mug L-1 for the real water samples.	Water	88-93	immunoglobulin kappa variable 1-16	Homo sapiens	71-74
28623871-0	2017	Simple computing of the viscosity of water-dioxane mixtures, according to a fluctuating SPC/E-Ih interstitial model.	Water	37-42	proline rich protein gene cluster	Homo sapiens	88-91
28623871-3	2017	The potential energy landscape is determined by the generalization of the Madelung"s approach to the molecular water network using simple point charge model (SPC/E partial charges).	Water	111-116	proline rich protein gene cluster	Homo sapiens	158-161
28624317-14	2017	Additionally, AMP/SUL increased the expression of GLT-1 and xCT in the dmPFC as compared to the water naive group.	Water	96-101	solute carrier family 1 member 2	Homo sapiens	50-55
28793048-5	2017	PLGA/BSA/VEGF showed the smallest water contact angle and VEGF released for up to 160 h. An improvement in cell adhesion was observed for the PLGA/BSA/VEGF scaffolds compared to the other groups and the scaffolds were non-toxic for the cells.	Water	34-39	vascular endothelial growth factor A	Homo sapiens	9-13
28608752-0	2017	Ferulic acid and its water-soluble derivatives inhibit nitric oxide production and inducible nitric oxide synthase expression in rat primary astrocytes.	Water	21-26	nitric oxide synthase 2	Rattus norvegicus	83-114
28267649-13	2017	EAU activity correlates with ocular IL-6 and IL-17 levels.	Water	0-3	interleukin 6	Mus musculus	36-40
28679296-2	2017	Research over the last decade has established a central role for SPAK in the regulation of ion and water transport in the distal nephron, colonic crypts, and pancreatic ducts, and has implicated deregulated SPAK signaling in NaCl-sensitive hypertension, ulcerative colitis and Crohn"s disease, and cystic fibrosis.	Water	99-104	serine/threonine kinase 39	Homo sapiens	65-69
28475979-2	2017	Conversely, when a waterbody is located in or near an urban area, the deposition of atmospheric PCBs may act as a low-level, ongoing source of PCB contamination to that water.	Water	19-24	pyruvate carboxylase	Homo sapiens	96-99
28475979-8	2017	The sum of air-water exchange fluxes of these PCB congeners was estimated to be 68 ng/m2/day (95% C.I.	Water	15-20	pyruvate carboxylase	Homo sapiens	46-49
28385297-0	2017	Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis.	Water	53-58	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	14-18
28546467-0	2017	Postexercise cold water immersion modulates skeletal muscle PGC-1alpha mRNA expression in immersed and nonimmersed limbs: evidence of systemic regulation.	Water	18-23	PPARG coactivator 1 alpha	Homo sapiens	60-70
28546467-2	2017	Therefore, we aimed to examine whether postexercise cold water immersion enhancement of PGC-1alpha mRNA is mediated through local or systemic mechanisms.	Water	57-62	PPARG coactivator 1 alpha	Homo sapiens	88-98
28546467-10	2017	We report for the first time that local cooling of the immersed limb evokes transcriptional control of PGC-1alpha in the nonimmersed limb, suggesting increased systemic beta-adrenergic activation of AMPK may mediate, in part, postexercise cold induction of PGC-1alpha mRNA.NEW &amp; NOTEWORTHY We report for the first time that postexercise cold water immersion of one limb also enhances PGC-1alpha expression in a contralateral, nonimmersed limb.	Water	346-351	PPARG coactivator 1 alpha	Homo sapiens	103-113
28774611-0	2017	TIC-Tox: A preliminary discussion on identifying the forcing agents of DBP-mediated toxicity of disinfected water.	Water	108-113	D-box binding PAR bZIP transcription factor	Homo sapiens	71-74
28774623-0	2017	Control of aliphatic halogenated DBP precursors with multiple drinking water treatment processes: Formation potential and integrated toxicity.	Water	71-76	D-box binding PAR bZIP transcription factor	Homo sapiens	33-36
28411545-3	2017	With the increase of P content in water from 0.02 mg L-1 to 0.20 and 2.4 mg L-1, consistent release of As from sediments was observed.	Water	34-39	immunoglobulin kappa variable 1-16	Homo sapiens	53-56
28774605-2	2017	This exploratory study was aimed at investigating the short-term impact of modifications of the water treatment process on traditional DBP levels (e.g., trihalomethanes (THMs), chloramines) and emerging DBPs (e.g., Halonitromethanes, Haloketones, NDMA) in swimming pool water and/or air.	Water	96-101	D-box binding PAR bZIP transcription factor	Homo sapiens	135-138
28774605-7	2017	This study shows that modifications affecting the water treatment process can rapidly produce important and variable impacts on DBP levels in water and air and suggests that implementation of any water treatment process to reduce DBP levels should take into account the specific context of each swimming pool.	Water	50-55	D-box binding PAR bZIP transcription factor	Homo sapiens	128-131
28774605-7	2017	This study shows that modifications affecting the water treatment process can rapidly produce important and variable impacts on DBP levels in water and air and suggests that implementation of any water treatment process to reduce DBP levels should take into account the specific context of each swimming pool.	Water	50-55	D-box binding PAR bZIP transcription factor	Homo sapiens	230-233
28774605-7	2017	This study shows that modifications affecting the water treatment process can rapidly produce important and variable impacts on DBP levels in water and air and suggests that implementation of any water treatment process to reduce DBP levels should take into account the specific context of each swimming pool.	Water	142-147	D-box binding PAR bZIP transcription factor	Homo sapiens	128-131
28431268-2	2017	The genotoxicity of water samples collected from different parts of Lake Sevan were assessed by means of Trad-SHM (stamen hair mutation) assay using Tradescantia (clone 02).	Water	20-25	RAD51 paralog D	Homo sapiens	105-109
28600680-8	2017	Remarkably, claudin-2 channels are also permeable to water so that 20-25% of proximal water absorption may occur paracellularly.	Water	53-58	claudin 2	Homo sapiens	12-21
28577072-1	2017	Vasopressin (AVP) induces antidiuresis, thus playing an essential role in body water and electrolyte homeostasis.	Water	79-84	arginine vasopressin	Homo sapiens	0-11
27865545-2	2017	Previous studies have shown that CGRP has roles in intestinal motility, water secretion, and inflammation.	Water	72-77	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	33-37
28600680-8	2017	Remarkably, claudin-2 channels are also permeable to water so that 20-25% of proximal water absorption may occur paracellularly.	Water	86-91	claudin 2	Homo sapiens	12-21
28600680-9	2017	Although the exact structure of the claudin-2 channel is still unknown, it is clear that Na+ and water share the same pore.	Water	97-102	claudin 2	Homo sapiens	36-45
28521045-13	2017	The partial pressure of water and oxygen were found to depend on the pump down parameters due to the formation of fog in the chamber and desorption of water from the birds and the walls of the vacuum chamber.	Water	24-29	zinc finger protein, FOG family member 1	Homo sapiens	114-117
28743289-12	2017	In immunohistochemistry, Th1 and Th17 cells invaded the retina in control EAU mice but not Dow2-treated EAU mice.	Water	74-77	negative elongation factor complex member C/D, Th1l	Mus musculus	25-28
30970989-1	2017	This study applied a facile and green approach to synthesize a stable graphene aqueous dispersion, and the graphene aqueous dispersion was employed to modify the renewable, compatible and biodegradable soy-protein-isolated (SPI) films to enhance their thermal stability, mechanical properties and water resistance.	Water	297-302	chromogranin A	Homo sapiens	224-227
27143047-3	2017	Aquaporin 1 is a cell membrane channel involved in water transport, cell motility, and proliferation.	Water	51-56	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
28505313-0	2017	Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition.	Water	75-80	RNA binding fox-1 homolog 1	Homo sapiens	24-29
28636330-0	2017	Water in Ionic Liquid Lubricants: Friend and Foe.	Water	0-5	WAPL cohesin release factor	Homo sapiens	45-48
28738491-12	2017	(4) The effect of H(2)O(2) on signaling molecules in PAECs: there was a significant increase in phosphorylation level of Akt in PAECs incubated with H(2)O(2) for 30 minutes compared to that in control PAECs (P&lt;0.01), while there was no significant difference in levels of Akt between H(2)O(2) treated PAECs and control PAECs.	Water	149-154	AKT serine/threonine kinase 1	Homo sapiens	275-278
28599082-1	2017	Fe(CO){CO(CH2 )5 CH2 -pyrene}(Cp)(PPh3 ) (Fp-pyrene) is soluble in DMSO and THF, but insoluble in water, methanol, and ethanol.	Water	98-103	caveolin 1	Homo sapiens	34-38
28738491-12	2017	(4) The effect of H(2)O(2) on signaling molecules in PAECs: there was a significant increase in phosphorylation level of Akt in PAECs incubated with H(2)O(2) for 30 minutes compared to that in control PAECs (P&lt;0.01), while there was no significant difference in levels of Akt between H(2)O(2) treated PAECs and control PAECs.	Water	18-23	AKT serine/threonine kinase 1	Homo sapiens	121-124
28720083-14	2017	The case-control study, which involved 49 confirmed cases and 201 controls, showed that 94% (46/49) of case-persons compared with 79% (160/201) of control-persons drank water without boiling or treatment (ORM-H=4.8, 95% CI: 1.3-18).	Water	169-174	orosomucoid 1	Homo sapiens	205-208
28738491-12	2017	(4) The effect of H(2)O(2) on signaling molecules in PAECs: there was a significant increase in phosphorylation level of Akt in PAECs incubated with H(2)O(2) for 30 minutes compared to that in control PAECs (P&lt;0.01), while there was no significant difference in levels of Akt between H(2)O(2) treated PAECs and control PAECs.	Water	18-23	AKT serine/threonine kinase 1	Homo sapiens	275-278
28738491-12	2017	(4) The effect of H(2)O(2) on signaling molecules in PAECs: there was a significant increase in phosphorylation level of Akt in PAECs incubated with H(2)O(2) for 30 minutes compared to that in control PAECs (P&lt;0.01), while there was no significant difference in levels of Akt between H(2)O(2) treated PAECs and control PAECs.	Water	149-154	AKT serine/threonine kinase 1	Homo sapiens	121-124
28734288-3	2017	In broad ranges of the molecular polarity, the studied SPC/E and TIP4P/2005 descendants show a density anomaly, which can be attributed to the removal of water molecules interstitial between the first and the second neighbor shells upon cooling.	Water	154-159	proline rich protein gene cluster	Homo sapiens	55-58
28724654-5	2017	Knockdown and knockout of Mfsd2a in mice markedly increased BBB permeability, neurological deficit score, and brain water contents after ICH, and these were rescued by overexpressing Mfsd2a in perihematomas.	Water	116-121	major facilitator superfamily domain containing 2A	Mus musculus	26-32
28724654-5	2017	Knockdown and knockout of Mfsd2a in mice markedly increased BBB permeability, neurological deficit score, and brain water contents after ICH, and these were rescued by overexpressing Mfsd2a in perihematomas.	Water	116-121	major facilitator superfamily domain containing 2A	Mus musculus	183-189
28650623-3	2017	The occurrence of  6DDT (0.10-66 pg L-1) in the surface water was dominated by 4,4"-DDE.	Water	56-61	immunoglobulin kappa variable 1-16	Homo sapiens	36-39
28510292-4	2017	As a result, the optimized Cd/CdO/CdS heterojunction photoanode showed outstanding and long-term photoelectrochemical activity for water splitting, with a current density of 3.52 mA cm-2 , or a benchmark specific hydrogen production rate of 1.65 mumol cm-2  min-1 at -0.3 V versus Ag/AgCl, by using the environmental pollutants of sulfide and sulfite as sacrificial agents.	Water	131-136	cell adhesion associated, oncogene regulated	Homo sapiens	30-33
28924378-8	2017	On the other hand, there are also other operative mechanisms when water is used as rehydration fluid that produce milder renal damage that is not fully corrected by vasopressin blockade.	Water	66-71	arginine vasopressin	Rattus norvegicus	165-176
28525373-7	2017	CONCLUSIONS: Liquid water metabolic abnormalities and intestine permeability alteration might be the mechanism of IBS by down-regulating AQP1, AQP3 and AQP8 via NF-kappaB pathway.	Water	20-25	aquaporin 8	Rattus norvegicus	152-156
28437020-1	2017	The activity of the water reduction catalyst [CoIII (L1 )(pyr)2 ]PF6 (1), where (L1 )2- is a bis-amido pyridine ligand and pyr is pyrrolidine, is investigated.	Water	20-25	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	46-51
28302307-0	2017	Bromine incorporation into five DBP classes upon chlorination of water with extremely low SUVA values.	Water	65-70	D-box binding PAR bZIP transcription factor	Homo sapiens	32-35
28852457-5	2017	In the SIADH, supraphysiologic levels of vasopressin (antidiuretic hormone, AVP) precipitates exorbitant free water retention and resultant electrolyte abnormalities, most notably hyponatremia.	Water	110-115	arginine vasopressin	Homo sapiens	41-52
28852457-5	2017	In the SIADH, supraphysiologic levels of vasopressin (antidiuretic hormone, AVP) precipitates exorbitant free water retention and resultant electrolyte abnormalities, most notably hyponatremia.	Water	110-115	arginine vasopressin	Homo sapiens	76-79
29741039-14	2017	The water consumption of dieback trees was less than non-dieback trees because the cumulative sap flow amount of dieback trees was lower.	Water	4-9	SH2 domain containing 1A	Homo sapiens	94-97
29964605-6	2017	The contribution of these water-soluble ions to PM2.5 showed that the proportion of sum of NO3-, SO42-, NH4+, NO2- and Cl- to PM2.5 was in range of 62.03%-80.93%.	Water	26-31	NBL1, DAN family BMP antagonist	Homo sapiens	91-94
28586217-4	2017	Experimental investigations and theoretical calculations confirm that the remarkable activity of the obtained material results from the unique 3D hierarchical architecture and interface reconstruction between Ni3Se2 and Co9S8 through Ni-S bonding, which leads to charge redistribution and thus lowers the energy barrier of hydrogen desorption in the water splitting process.	Water	350-355	solute carrier family 5 member 5	Homo sapiens	234-238
29964615-11	2017	In the sea area with strong water exchange, concentrations of total n-alkanes were around 2.196 mug L-1, which could be considered as the environmental background level of n-alkanes in Jiaozhou Bay.	Water	28-33	immunoglobulin kappa variable 1-16	Homo sapiens	100-103
29964629-2	2017	DBP precursors in these water samples were characterized with fluorescence excitation emission matrix, Fourier transformation infrared and nuclear magnetic resonance, and were further tested for their DBP formation potential(DBPFP) after chlorination.	Water	24-29	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
28643829-3	2017	Against expectations, millimolar CPA (a surface-active C10 keto-carboxylic acid possessing a rigid skeleton) is able to compete with 23 M bulk water for the CIs produced in the ozonolysis of sesquiterpene solutes by O3(g) on the surface of a water:acetonitrile solvent.	Water	242-247	homeobox C10	Homo sapiens	55-58
30970951-1	2017	In this study, a novel coordination polymer [CdL2(H2O)0.5]n (1), [HL = 4-(2-(4-((pyridin-3-yl)methoxy)phenyl)diazenyl)benzoic acid] was fabricated via an in situ ligand transformation reaction under solvothermal conditions.	Water	50-53	Cornelia de Lange syndrome 2	Homo sapiens	45-49
28342358-1	2017	Highly efficient simultaneous removal of Pb(II) and p-nitrophenol (PNP) contamination from water was accomplished by nitrogen-functionalized magnetic ordered mesoporous carbon (N-Fe/OMC).	Water	91-96	submaxillary gland androgen regulated protein 3B	Homo sapiens	41-47
28552303-6	2017	The method was successively applied to the determination of pyrethroid pesticides in different kinds of water samples with the limits of detection ranged from 0.16 to 0.21 mug L-1.	Water	104-109	immunoglobulin kappa variable 1-16	Homo sapiens	176-179
28740387-4	2017	Water-insoluble apatinib was encapsulated in nanoparticles composed of human serum albumin (HSA)-conjugated polyethylene glycol (PEG).	Water	0-5	albumin	Homo sapiens	77-90
28722461-8	2017	Activation of renin-angiotensin-aldosterone system and non-osmotic stimulation of antidiuretic hormone trigger serious changes in water and natrium-chloride metabolism.	Water	130-135	renin	Homo sapiens	14-19
28586102-6	2017	After being encapsulated with biodegradable copolymer pluronic F-127-folic acid (F-127-FA), RET-BDP molecules can form uniform and small organic nanoparticles that are water soluble and tumor targetable.	Water	168-173	AT-rich interaction domain 3B	Homo sapiens	96-99
28298358-1	2017	The gene encoding the aquaporin-2 water channel is regulated transcriptionally in response to vasopressin.	Water	34-39	arginine vasopressin	Rattus norvegicus	94-105
28433181-1	2017	A water-soluble polysaccharide SPS2p was isolated from the whole grass of Scutellaria barbata and SPS2p contained 53.6% carbohydrates, 38.5% uronic acid and 8.2% proteins.	Water	2-7	selenophosphate synthetase 2	Homo sapiens	31-36
28433181-1	2017	A water-soluble polysaccharide SPS2p was isolated from the whole grass of Scutellaria barbata and SPS2p contained 53.6% carbohydrates, 38.5% uronic acid and 8.2% proteins.	Water	2-7	selenophosphate synthetase 2	Homo sapiens	98-103
28613850-0	2017	A Highly Selective and Robust Co(II)-Based Homogeneous Catalyst for Reduction of CO2 to CO in CH3CN/H2O Solution Driven by Visible Light.	Water	100-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
28613850-3	2017	Herein, we report a Co(II)-based homogeneous catalyst, [Co(NTB)CH3CN](ClO4)2 (1, NTB = tris(benzimidazolyl-2-methyl)amine), which shows high selectivity and stability for the catalytic reduction of CO2 to CO in a water-containing system driven by visible light, with turnover number (TON) and turnover frequency (TOF) values of 1179 and 0.032 s-1, respectively, and selectivity to CO of 97%.	Water	213-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28695859-1	2017	Solutions of lysozyme in heavy water were studied by small-angle neutron scattering (SANS) at concentrations of 40, 20 and 10 mg ml-1 with and without the addition of precipitant, and at temperatures of 10, 20 and 30 C. In addition to the expected protein monomers, dimeric and octameric species were identified in solutions at the maximum concentration and close to the optimal conditions for crystallization.	Water	31-36	lysozyme	Homo sapiens	13-21
28555399-3	2017	The main target values for water parameters are the following: conductivity &lt;10 muScm-1, TOC &lt; 10 mg L-1, and Al &lt; 0.1 mg L-1.	Water	27-32	immunoglobulin kappa variable 1-16	Homo sapiens	107-110
28555399-3	2017	The main target values for water parameters are the following: conductivity &lt;10 muScm-1, TOC &lt; 10 mg L-1, and Al &lt; 0.1 mg L-1.	Water	27-32	immunoglobulin kappa variable 1-16	Homo sapiens	131-134
28507171-12	2017	Sodium and water excretion increased in the absence of significant hemodynamic perturbation, supporting a direct action of ET-1 on the renal tubule.	Water	11-16	endothelin 1	Homo sapiens	123-127
28498409-9	2017	In the present study, we also showed that the systemic administration of a water soluble NSC311153 analog in a mouse MTC xenograft model inhibited the tumor growth through RET downregulation.	Water	75-80	ret proto-oncogene	Mus musculus	172-175
31966617-0	2017	Irisin attenuates H2O2-induced apoptosis in cardiomyocytes via microRNA-19b/AKT/mTOR signaling pathway.	Water	18-22	AKT serine/threonine kinase 1	Rattus norvegicus	76-79
31966617-13	2017	Further study demonstrated that Irisin-regulated miR-19b could reactivate the AKT/mTOR signaling pathway blocked by H2O2 in H9c2 cells.	Water	116-120	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
28334987-6	2017	The method was linear in the concentration range from 5 to 500 mug L-1 for DEET in baby toilet water and good linearity (r2 &gt; 0.9998) was obtained for the calibration curve.	Water	95-100	immunoglobulin kappa variable 1-16	Homo sapiens	67-70
28284130-3	2017	Here we report the performances of the in situ oxidized Fe3O4 membranes for removing two toxic cations Cd(II) and Pb(II) commonly existing in water and their potential applications for drinking water purification.	Water	142-147	submaxillary gland androgen regulated protein 3B	Homo sapiens	103-120
28284130-10	2017	The membranes were able to efficiently lower Cd(II) and Pb(II) concentrations to meet the drinking water standards recommended by the World Health Organization and are promising for engineering applications aimed at drinking water purification.	Water	99-104	submaxillary gland androgen regulated protein 3B	Homo sapiens	45-62
28808395-12	2017	SUMMARY: The gallotannin (69.2%), gallic acid (26.6%), and methyl gallate (4.2%) are the main constituents of water extracts of GRGEGR was more potent in DPPH scavenging, and gallotannin contributes to this extract activityGEGR significantly reduced the increase of apoptosis, Bax/Bcl-2 ratio, and active caspase-3 level after H2O2 treatmentGEGR pretreatment showed protection against H2O2-induced ROS production in DCFH-DA staining analysis.	Water	110-115	BCL2 associated X, apoptosis regulator	Homo sapiens	277-280
28389059-11	2017	The change in Cys-C eGFR is significant but smaller for the shake and burger group, which may be due to the dilutional effect of water loading or the length of Cys-C half-life in the blood.	Water	129-134	epidermal growth factor receptor	Homo sapiens	20-24
28875746-1	2017	BACKGROUND: Renin-angiotensin-aldosterone system (RAAS) activation in heart failure with reduced ejection fraction (HFREF) is detrimental through promotion of ventricular remodeling and salt and water retention.	Water	195-200	renin	Homo sapiens	12-17
28586071-11	2017	The present study provides further evidence that a PHEMA stent structure, comprised of a high number of matrixes and a low water content, induces a high level of ASC differentiation to myocardial cells.	Water	123-128	PYD and CARD domain containing	Homo sapiens	162-165
28539434-6	2017	Efferent ductules and epididymal functions are dependent on estrogen signaling through ESR1, whose loss impaired ion transport and water reabsorption, resulting in abnormal sperm.	Water	131-136	estrogen receptor 1	Homo sapiens	87-91
28808395-12	2017	SUMMARY: The gallotannin (69.2%), gallic acid (26.6%), and methyl gallate (4.2%) are the main constituents of water extracts of GRGEGR was more potent in DPPH scavenging, and gallotannin contributes to this extract activityGEGR significantly reduced the increase of apoptosis, Bax/Bcl-2 ratio, and active caspase-3 level after H2O2 treatmentGEGR pretreatment showed protection against H2O2-induced ROS production in DCFH-DA staining analysis.	Water	110-115	BCL2 apoptosis regulator	Homo sapiens	281-286
28808395-12	2017	SUMMARY: The gallotannin (69.2%), gallic acid (26.6%), and methyl gallate (4.2%) are the main constituents of water extracts of GRGEGR was more potent in DPPH scavenging, and gallotannin contributes to this extract activityGEGR significantly reduced the increase of apoptosis, Bax/Bcl-2 ratio, and active caspase-3 level after H2O2 treatmentGEGR pretreatment showed protection against H2O2-induced ROS production in DCFH-DA staining analysis.	Water	110-115	caspase 3	Homo sapiens	305-314
28617514-2	2017	The stability of the complex was studied under air and N2 atmospheres and in CDCl3, DMSO, water and the cell culture medium, at room temperature and 40  C. The complex showed an enhanced antiproliferative activity (up to six-fold) when compared with its parent complex [RuCp(PPh3)2(HdmoPTA)]2+ against human lung, cervix, breast, and colon solid tumor cell lines.	Water	90-95	caveolin 1	Homo sapiens	275-279
28570821-2	2017	Fe(CO){CO(CH2)n-1CH3}(Cp)(PPh3) molecules (FpCn) with a Fp head and alkyl tail are water-insoluble.	Water	83-88	caveolin 1	Homo sapiens	26-30
28714368-4	2017	Cordyceps militaris hot water extracts containing cordycepin was used to treat human T24 bladder carcinoma cells, and we found that Cordyceps militaris hot water extracts containing cordycepin decreased T24 cell survival in a dose-dependent manner, which was seemingly mediated by activation of A3 adenosine receptor and the subsequent inactivation of Akt pathways, resulting in increases in cleaved Caspase-3 and apoptosis.	Water	156-161	AKT serine/threonine kinase 1	Homo sapiens	352-355
28541662-5	2017	Water in the pores of the entire MPL was detected and quantified.	Water	0-5	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	33-36
28541662-8	2017	Furthermore, high water saturation in large areas hints at gas diffusion or transport along preferred three-dimensional paths through the material, therefore bypassing most of the MPL volume.	Water	18-23	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	180-183
30970924-2	2017	However, SPI-based films exhibit relatively poor mechanical properties and water resistance ability.	Water	75-80	chromogranin A	Homo sapiens	9-12
28526744-4	2017	Molecular docking, including the prediction of water-mediated interactions, was used to model interactions between the ligands and the PI3Kalpha affinity pocket.	Water	47-52	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	135-144
28537745-2	2017	In this study, we perform a systematic study on how mixtures of organic solvent probes in water can reveal cryptic ligand binding pockets that are not evident in crystal structures of apo proteins.	Water	90-95	cripto, FRL-1, cryptic family 1	Homo sapiens	107-114
28723110-3	2017	Thanks to the ultrasmall channel size (2-3 nm in diameter), high channel density (4 x 108 mum-2), and ultrathin thickness (80 nm) of SIM, the ensemble of nanoscopic water/organogel (nano-W/Gel) interface array behaved like a microinterface with two back-to-back hemispherical mass diffusion zones.	Water	165-170	latexin	Homo sapiens	90-93
28214620-3	2017	In this work, the synthesis of a porphyrin-based water soluble nanoparticle conjugate containing a targeting agent that recognizes the erbB2 receptor overexpressed on the surface of particular cancer cells is reported.	Water	49-54	erb-b2 receptor tyrosine kinase 2	Homo sapiens	135-140
28537706-2	2017	Here we comparatively study the catalytic performance of two single-atom catalysts, Na1/HMO and Ag1/HMO (HMO = Hollandite manganese oxide), in the complete oxidation of HCHO at low temperatures, in which the products are only CO2 and H2O.	Water	234-237	thioredoxin domain containing 12	Homo sapiens	84-103
28635641-5	2017	Water quality of the effluent discharged from the rig was found to be suitable for discharge to most environments.	Water	0-5	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	50-53
28410268-5	2017	Pretreatment of BoNT/A also attenuated chronic itch induced by acetone-diethylether-water treatment and abolished the upregulation of TRPA1 in the DRG.	Water	84-89	itchy, E3 ubiquitin protein ligase	Mus musculus	47-51
28534627-0	2017	Highly Stable and Regenerative Metal-Organic Framework Designed by Multiwalled Divider Installation Strategy for Detection of Co(II) Ions and Organic Aromatics in Water.	Water	163-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
28498675-3	2017	In this work, based on extensive explicit solvent simulations employing TIP3P and SPC/E water models we analyze hydration free energy changes between fixed conformations of 5 diverse proteins, including large multidomain structures.	Water	88-93	proline rich protein gene cluster	Homo sapiens	82-85
28573307-1	2017	We report a combined experimental characterization and theoretical modeling of the hexa-coordinated high-spin Co(ii) complex cis-[Co(hfac)2(H2O)2] (I).	Water	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-115
28773012-7	2017	The synergy of HNTs and CMCS via electrostatic interactions also improved the water resistance of the SPI/PTGE/HNTs/CMCS film.	Water	78-83	chromogranin A	Homo sapiens	102-105
28467806-5	2017	For the highly water soluble glucose-conjugated complex (5a), two novel in vivo assessments were conducted and the results revealed that 5a was more efficacious at a lower equitoxic dose (70% MTD) than oxaliplatin (100% MTD) in HT29 xenograft model, and it was significantly more potent than oxaliplatin in leukemia-bearing DBA/2 mice as well even at equimolar dose levels (18% vs 90% MTD).	Water	15-20	BCL2-related ovarian killer	Mus musculus	192-195
32665782-6	2017	From a water quality perspective, the DOC : NO3 - ratio of streamwater was significantly different across infrastructure categories.	Water	7-12	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
28260383-7	2017	The directional delivery of the collected fog droplets by wavy/v-shaped microgrooves on the surface of the fibers enhances the formation of a water film and their fog collection.	Water	142-147	zinc finger protein, FOG family member 1	Homo sapiens	42-45
28642767-6	2017	As a result, a Si-mediated upregulation of aquaporin (PIP) gene expression is observed in relation to increased root hydraulic conductivity and water uptake.	Water	144-149	prolactin induced protein	Homo sapiens	54-57
28488858-4	2017	In case study one, a series of anion exchange resins have been screened for selective removal of NO3- and NO2- in water environments consisting of multiple other anions, varied pH, and ionic strength.	Water	114-119	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
28607409-5	2017	We identified an efficient water-specific AQP (ClAQP1), two aquaglyceroporins (ClGlp1 and ClGlp2) and a homolog of Drosophila melanogaster big brain (ClBib).	Water	27-32	aquaporin	Drosophila melanogaster	42-45
28607409-6	2017	ClGlp1 was only functional when co-expressed with the water-specific AQP.	Water	54-59	aquaporin	Drosophila melanogaster	69-72
28576085-0	2017	Lysozyme in water-acetonitrile mixtures: Preferential solvation at the inner edge of excess hydration.	Water	12-17	lysozyme	Homo sapiens	0-8
28576085-4	2017	At high water content, the lysozyme has a higher affinity for water than for acetonitrile.	Water	8-13	lysozyme	Homo sapiens	27-35
28576085-4	2017	At high water content, the lysozyme has a higher affinity for water than for acetonitrile.	Water	62-67	lysozyme	Homo sapiens	27-35
28576085-6	2017	At the intermediate water content, the dehydrated lysozyme has a higher affinity for acetonitrile than for water.	Water	20-25	lysozyme	Homo sapiens	50-58
28576085-6	2017	At the intermediate water content, the dehydrated lysozyme has a higher affinity for acetonitrile than for water.	Water	107-112	lysozyme	Homo sapiens	50-58
28576085-8	2017	At the lowest water content, the organic solvent molecules are preferentially excluded from the dried lysozyme, resulting in the preferential hydration.	Water	14-19	lysozyme	Homo sapiens	102-110
28576085-11	2017	At high and intermediate water content, lysozyme is preferentially hydrated.	Water	25-30	lysozyme	Homo sapiens	40-48
28576085-13	2017	At low water content, the preferential binding of the acetonitrile molecules to the initially hydrated lysozyme was detected.	Water	7-12	lysozyme	Homo sapiens	103-111
28586369-0	2017	Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system.	Water	64-69	epidermal growth factor receptor	Homo sapiens	46-58
28586369-2	2017	In vitro analysis of ErbB receptor kinases can be difficult because of their large size and poor water solubility.	Water	97-102	epidermal growth factor receptor	Homo sapiens	21-25
28260383-7	2017	The directional delivery of the collected fog droplets by wavy/v-shaped microgrooves on the surface of the fibers enhances the formation of a water film and their fog collection.	Water	142-147	zinc finger protein, FOG family member 1	Homo sapiens	163-166
28636801-3	2017	In contrast, the contribution, or even existence, of a specific paracellular water pathway has been disputed for a long time, until the cation channel-forming tight junction protein claudin-2 was shown to also permit the paracellular passage of water through its pore.	Water	77-82	claudin 2	Homo sapiens	182-191
28377431-4	2017	Binding ANP or BNP to natriuretic peptide receptor A induces cyclic guanylyl monophosphate as second messenger in the target cells to mediate the following: natriuresis; water diuresis; increasing glomerular filtration rate; decreasing systemic sympathetic activities; plasma volume; cardiac output and blood pressure; and curbing mitoses of heart fibroblasts and hypertrophy of cardiovascular muscle cells.	Water	170-175	natriuretic peptide receptor 1	Homo sapiens	22-52
28490451-1	2017	Direct intracerebroventricular injection of angiotensin II (ANG II) causes increases in blood pressure and salt and water intake, presumably mimicking an effect mediated by an endogenous mechanism.	Water	116-121	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	44-58
28490451-1	2017	Direct intracerebroventricular injection of angiotensin II (ANG II) causes increases in blood pressure and salt and water intake, presumably mimicking an effect mediated by an endogenous mechanism.	Water	116-121	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	60-66
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Water	107-112	solute carrier family 11 member 2	Rattus norvegicus	189-196
28584238-4	2017	Highly sensitive and selective detection of Hg2+ ions is achieved in both distilled and tap water samples, indicating the feasibility and applicability of our device for the determination of mercury pollution in real samples.	Water	92-97	SEC14 like lipid binding 2	Homo sapiens	88-91
28552909-3	2017	In this study, we synthesized transferrin (Tf)-modified poly(D,L-lactic-co-glycolic acid) nanoparticles (PLGA NPs) loaded with paclitaxel (PTX) and superparamagnetic nanoparticle (MNP) using a solid-in-oil-in-water solvent evaporation method, followed by Tf adsorption on the surface of NPs.	Water	209-214	transferrin	Homo sapiens	30-41
28636801-3	2017	In contrast, the contribution, or even existence, of a specific paracellular water pathway has been disputed for a long time, until the cation channel-forming tight junction protein claudin-2 was shown to also permit the paracellular passage of water through its pore.	Water	245-250	claudin 2	Homo sapiens	182-191
28636801-4	2017	In proximal kidney tubules, claudin-2-based water transport contributes 23-30% of the total water transport.	Water	44-49	claudin 2	Homo sapiens	28-37
28636801-4	2017	In proximal kidney tubules, claudin-2-based water transport contributes 23-30% of the total water transport.	Water	92-97	claudin 2	Homo sapiens	28-37
28725324-8	2017	Vasopressin receptor antagonists (VRAs), such as vaptans, are potent aquaretics causing electrolyte-free water diuresis without significant electrolyte abnormalities.	Water	105-110	arginine vasopressin	Homo sapiens	0-11
28404373-2	2017	Glu-PTX2 could self-assemble into nanoparticles (Glu-PTX2 NPs) in aqueous solution to increase the water solubility of PTX.	Water	99-104	paired like homeodomain 2	Homo sapiens	4-8
28404373-2	2017	Glu-PTX2 could self-assemble into nanoparticles (Glu-PTX2 NPs) in aqueous solution to increase the water solubility of PTX.	Water	99-104	paired like homeodomain 2	Homo sapiens	53-57
28344130-1	2017	Aquaporin-3 (AQP3), a transporter of water, glycerol and H2O2, is expressed in basolateral membranes of principal cells in kidney collecting duct.	Water	37-42	aquaporin 3	Mus musculus	0-11
28344130-1	2017	Aquaporin-3 (AQP3), a transporter of water, glycerol and H2O2, is expressed in basolateral membranes of principal cells in kidney collecting duct.	Water	37-42	aquaporin 3	Mus musculus	13-17
28419963-2	2017	PCS was prepared by water extracting-alcohol precipitating method, and its chemical compositions of monosaccharide were analyzed.	Water	20-25	PCS	Homo sapiens	0-3
28616208-2	2017	Vasopressin drives cysts growth and in animal models can be suppressed through high water intake.	Water	84-89	arginine vasopressin	Homo sapiens	0-11
28292723-4	2017	Water samples taken below an agriculture field in Lower Saxony revealed the permanent entrance of sulfamethazine into groundwater and concentrations up to 100 ng L-1 were determined.	Water	0-5	immunoglobulin kappa variable 1-16	Homo sapiens	162-165
28282582-1	2017	Catalase, a heme enzyme, which catalyzes decomposition of hydrogen peroxide to water and molecular oxygen, is one of the main enzymes of the antioxidant defense system of the cell.	Water	79-84	catalase	Homo sapiens	0-8
28439687-6	2017	In recharge water, the colloid mass concentrations retained by 100-kDa-0.45-mum and 50-kDa-100-kDa membranes were 3 and 99 mg/L, respectively.	Water	12-17	latexin	Homo sapiens	76-79
28384618-0	2017	Microwave dielectric spectroscopy study of water dynamics in normal and contaminated raw bovine milk.	Water	43-48	Weaning weight-maternal milk	Bos taurus	96-100
28384618-1	2017	The role of water in bovine milk is more complicated than that of a background solvent.	Water	12-17	Weaning weight-maternal milk	Bos taurus	28-32
28384618-6	2017	This entropy/enthalpy compensation is traced to the interaction between bulk water dynamic clusters and other milk constituents.	Water	77-82	Weaning weight-maternal milk	Bos taurus	110-114
28530193-0	2017	Surface adsorption of poisonous Pb(II) ions from water using chitosan functionalised magnetic nanoparticles.	Water	49-54	submaxillary gland androgen regulated protein 3B	Homo sapiens	32-38
28250447-6	2017	While exposure to fog strongly compromises the water-repellency of hydrophobic structures, this failure can be minimized by scaling the texture down to nanosize.	Water	47-52	zinc finger protein, FOG family member 1	Homo sapiens	18-21
28298306-7	2017	Finally, stable overexpression of miR-372 inhibitor in hNSC rescued the IL-1beta-induced impairment as shown by significant improvements in tissue water content, myeloperoxidase activity, and behavioral assessments in SCI rats.	Water	147-152	interleukin 1 beta	Rattus norvegicus	72-80
27576172-8	2017	When HBSMCs were subjected to 200-300 cm H2 O pressure for 2-24 h in vitro, the expressions of IL-6 and RANTES were significantly increased.	Water	41-45	interleukin 6	Homo sapiens	95-99
28588722-4	2017	The inductive agent, doxycycline (Dox), was added to the water for long-term silencing of MED23 in intratumoral cells.	Water	57-62	mediator complex subunit 23	Homo sapiens	90-95
28202096-1	2017	OBJECTIVE: The Crunch&amp;Sip programme is a school-based nutrition initiative designed to increase the fruit, vegetable and water intakes of primary-school children.	Water	125-130	tumor protein p53 inducible nuclear protein 1	Homo sapiens	26-29
28416584-5	2017	2-Methoxyestradiol reduced Ang II-induced increases in systolic blood pressure, water consumption, urine output, and proteinuria in intact female Cyp1b1-/- and ovariectomized mice.	Water	80-85	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	27-33
28416584-6	2017	2-Methoxyestradiol also reduced Ang II-induced increase in blood pressure, water intake, urine output, and proteinuria in Cyp1b1+/+ male mice.	Water	75-80	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	32-38
27620834-4	2017	Co-expression of AtPIP2;1 with AtPIP1;2 increased water permeability but abolished the ionic conductance.	Water	50-55	plasma membrane intrinsic protein 1B	Arabidopsis thaliana	31-39
28620355-4	2017	Moreover, after water deprivation or salt loading, in humans and in rodents, AVP and apelin are conversely regulated to facilitate systemic AVP release and to avoid additional water loss from the kidney.	Water	16-21	arginine vasopressin	Homo sapiens	77-80
28620355-4	2017	Moreover, after water deprivation or salt loading, in humans and in rodents, AVP and apelin are conversely regulated to facilitate systemic AVP release and to avoid additional water loss from the kidney.	Water	16-21	apelin	Homo sapiens	85-91
28620355-4	2017	Moreover, after water deprivation or salt loading, in humans and in rodents, AVP and apelin are conversely regulated to facilitate systemic AVP release and to avoid additional water loss from the kidney.	Water	176-181	arginine vasopressin	Homo sapiens	77-80
28603419-0	2017	In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies.	Water	23-28	albumin	Homo sapiens	70-83
28620355-4	2017	Moreover, after water deprivation or salt loading, in humans and in rodents, AVP and apelin are conversely regulated to facilitate systemic AVP release and to avoid additional water loss from the kidney.	Water	176-181	apelin	Homo sapiens	85-91
28919932-5	2017	From docking studies it was revealed that water and hydrogen-bond networks are essential for substrate binding, thus allowing aliphatic aldehydes to be converted in the charged active site of transketolase.	Water	42-47	transketolase	Homo sapiens	192-205
28470321-1	2017	A Mn(i) tris(2-pyridylmethyl)amine complex fac-[Mn(kappa3-tpa) (CO)3]+OTf- carries out electrocatalytic hydrogen evolution from neutral water in acetonitrile.	Water	136-141	FA complementation group C	Homo sapiens	43-46
28555006-4	2017	A CTD device consists of Conductivity (C), Temperature (T) and Depth (D) probes to monitor the water column changes with respect to relative depth.	Water	95-100	CTD	Homo sapiens	2-5
28570541-6	2017	NGF is a water-soluble protein of 26 kDa.	Water	9-14	nerve growth factor	Homo sapiens	0-3
28557965-4	2017	Moreover, abnormally elevated levels of uric acid results in the activation of renin-angiotensinaldosterone system and thus it may be associated with disturbances of water and electrolyte balance and the appearance of hypertension.	Water	166-171	renin	Homo sapiens	79-84
28152440-5	2017	Whereas ion exchange between Cl- and SO42- counter-ions in the polymer and NO3- from water is the main responsible for the effective nitrate removal in PANI, as assessed by FTIR and XPS analyses, the nitrate removal mechanism on PPy is based in an electron transfer from the polymer to nitrate through N sites located in the pyrrolic ring.	Water	85-90	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
28467070-4	2017	In aqueous media (1% dimethyl sulfoxide in H2O), the two photodecarbonylation steps proceed much more slowly (k1 = 0.46-1.3 min-1 and k2 = 0.026-0.035 min-1, respectively) and the influence of the carboxyl groups is less pronounced.	Water	43-46	CD59 molecule (CD59 blood group)	Homo sapiens	124-129
28467070-4	2017	In aqueous media (1% dimethyl sulfoxide in H2O), the two photodecarbonylation steps proceed much more slowly (k1 = 0.46-1.3 min-1 and k2 = 0.026-0.035 min-1, respectively) and the influence of the carboxyl groups is less pronounced.	Water	43-46	CD59 molecule (CD59 blood group)	Homo sapiens	151-156
28259812-7	2017	Reducing the intensity of the solution recirculation from 60 to 10 mL min-1 significantly reduced specific energy consumption of the e-FO system from 0.693 +- 0.127 to 0.022 +- 0.004 kWh m-3 extracted water or from 1.103 +- 0.059 to 0.044 +- 0.002 kWh kg-1 reduced reversed solute.	Water	201-206	CD59 molecule (CD59 blood group)	Homo sapiens	70-75
28215800-8	2017	Coagulation between Ca2+ and SO42- in surface adsorbed water is observed after part conversion of CaCO3 to Ca(NO3)2, resulting in the formation of CaSO4 2H2O at 80% RH.	Water	55-60	NBL1, DAN family BMP antagonist	Homo sapiens	110-113
28341147-9	2017	Immunocytochemistry of lungs of mice exposed to low-dose Cd (0.3 and 1.0mg/L in drinking water) showed increased alpha-SMA protein level with lung Cd accumulation similar to lung Cd in non-smoking humans.	Water	89-94	actin alpha 2, smooth muscle, aorta	Mus musculus	113-122
28336531-2	2017	Here, we describe a mechanism that accounts for the ability of the peptide hormone vasopressin to regulate water excretion via a phosphorylation-dependent modulation of the PDZ domain-ligand interaction involving the water channel protein aquaporin-2.	Water	107-112	arginine vasopressin	Homo sapiens	83-94
28391978-2	2017	Normally, superoxide dismutase (SOD) converts superoxide anions to hydrogen peroxide (H2O2) and H2O2 is then naturalized to be water by peroxiredoxin 4.	Water	127-132	peroxiredoxin 4	Rattus norvegicus	136-151
28328176-0	2017	Glucose-Responsive Supramolecular Vesicles Based on Water-Soluble Pillar[5]arene and Pyridylboronic Acid Derivatives for Controlled Insulin Delivery.	Water	52-57	insulin	Homo sapiens	132-139
28467818-6	2017	Here we develop surrogate Wnt agonists, water-soluble FZD-LRP5/LRP6 heterodimerizers, with FZD5/FZD8-specific and broadly FZD-reactive binding domains.	Water	40-45	LDL receptor related protein 5	Homo sapiens	58-62
28430436-1	2017	Here we reveal details of the interaction between human lysozyme proteins, both native and fibrils, and their water environment by intense terahertz time domain spectroscopy.	Water	110-115	lysozyme	Homo sapiens	56-64
28467818-6	2017	Here we develop surrogate Wnt agonists, water-soluble FZD-LRP5/LRP6 heterodimerizers, with FZD5/FZD8-specific and broadly FZD-reactive binding domains.	Water	40-45	frizzled class receptor 8	Homo sapiens	96-100
28490769-6	2017	Heat stroke cases showed an increase in brain water content, which was found to be positively correlated with MMP9, OCLN, ZO1 and CLDN5 mRNA.	Water	46-51	tight junction protein 1	Homo sapiens	122-125
28493967-0	2017	Water permeation through the internal water pathway in activated GPCR rhodopsin.	Water	0-5	rhodopsin	Homo sapiens	70-79
28493967-0	2017	Water permeation through the internal water pathway in activated GPCR rhodopsin.	Water	38-43	rhodopsin	Homo sapiens	70-79
28493967-2	2017	Internal water molecules mediate activation of the receptor in a rhodopsin cascade reaction and contribute to conformational stability of the receptor.	Water	9-14	rhodopsin	Homo sapiens	65-74
28493967-9	2017	These findings revealed a total water flux between the bulk and the protein inside in the Meta II state, and suggested that these pathways provide water molecules to the crucial sites of the activated rhodopsin.	Water	32-37	rhodopsin	Homo sapiens	201-210
28493967-9	2017	These findings revealed a total water flux between the bulk and the protein inside in the Meta II state, and suggested that these pathways provide water molecules to the crucial sites of the activated rhodopsin.	Water	147-152	rhodopsin	Homo sapiens	201-210
29965089-3	2017	The ranges of geometric mean values were 0-655 ng L-1 and 0-252 ng L-1 in water samples from urban rivers and lakes,respectively.	Water	74-79	L1 cell adhesion molecule	Homo sapiens	50-70
28407337-1	2017	Complex formation between cationic cytochrome c and the water-soluble, poly-anionic p-phosphonatocalix[6]arene (pclx6 ) was investigated.	Water	56-61	cytochrome c, somatic	Homo sapiens	35-47
28323094-3	2017	Here, denatured soy protein isolate (SPI)-coated docetaxel nanosuspensions (DTX-NS) were developed using an anti-solvent precipitation-ultrasonication method to improve the water-solubility of DTX, thus improving its intracellular delivery.	Water	173-178	chromogranin A	Homo sapiens	37-40
28368059-5	2017	Therefore, BRI can act as an "OFF-ON" fluorescent probe switch in CH3CN/H2O (3 : 2 v/v) with a detection limit of 1 muM in solution, whereas RhB1 and RhB1-CD act as "ON-OFF" fluorescent probes in EtOH/H2O (1 : 1 v/v) and water, respectively, with a detection limit of 10 muM.	Water	72-75	latexin	Homo sapiens	116-119
25875248-5	2017	It has been reported that uptake of trace elements and radionuclides from the oil palm tree may be from water and soil on the palm plantations.	Water	104-109	paralemmin	Homo sapiens	82-86
25875248-5	2017	It has been reported that uptake of trace elements and radionuclides from the oil palm tree may be from water and soil on the palm plantations.	Water	104-109	paralemmin	Homo sapiens	126-130
28286126-6	2017	In addition, we observed changes in the circadian day-night expression of the clock gene Per2 in the SCN, cortex and striatum of animals ingesting sucrose compared to control mice on pure water.	Water	188-193	period circadian clock 2	Mus musculus	89-93
27279485-4	2017	Some of the better-characterized regulators of water and salt homeostasis include angiotensin II, aldosterone, arginine vasopressin, and oxytocin.	Water	47-52	angiotensinogen	Homo sapiens	82-96
28373558-6	2017	This is confirmed by the distribution of the AQP1 water channel within endothelial membranes.	Water	50-55	aquaporin 1 (Colton blood group)	Homo sapiens	45-49
28160681-2	2017	The results show that the soluble iron in the investigated water samples was sufficiently effective for reaction with H2O2 in the simulated rainwater-affected stagnant water to produce OH (Fenton reaction), which inactivated coliform bacteria even at a H2O2 dose as low as 5 muM within just 1 min of contact time.	Water	144-149	latexin	Homo sapiens	275-278
28237603-12	2017	Skeletal muscle IGF-1 transcripts were also significantly increased by 1.9-5.1 fold through the 52 weeks of grow-out in clean by water in the 800ppb embryonic exposure group.	Water	129-134	insulin-like growth factor I	Fundulus heteroclitus	16-21
28249898-8	2017	In vivo, 200 mmol/L NaHCO3 added to the drinking water of 4-week-old TRAMP mice increased the intraprostatic pHe by 0.2 units and promoted proliferation of noninvasive C3 cells, which remained confined within the ducts so that primary cancer did not develop.	Water	49-54	tumor necrosis factor receptor superfamily, member 25	Mus musculus	69-74
28267495-2	2017	The investigation aimed to prepare soy hull hemicelluloses-soy protein isolate (SHH-SPI) conjugates by Maillard reaction in a controlled dry state condition and assess the suitability of the conjugates in stabilizing oil-in-water (O/W) emulsion.	Water	224-229	chromogranin A	Homo sapiens	84-87
28226279-4	2017	We investigated the response times of decamethylcyclopentasiloxane (D5) and PCB-180 concentrations in water and sediment under three emission scenarios in three different aquatic systems, namely Lake Ontario, Oslofjord, and Lake Pepin.	Water	102-107	pyruvate carboxylase	Homo sapiens	76-79
27990576-5	2017	Concomitantly, ancient v2r gene expression begins to appear in the basal layers of the newly forming water nose.	Water	101-106	arginine vasopressin receptor 2	Homo sapiens	23-26
28160681-2	2017	The results show that the soluble iron in the investigated water samples was sufficiently effective for reaction with H2O2 in the simulated rainwater-affected stagnant water to produce OH (Fenton reaction), which inactivated coliform bacteria even at a H2O2 dose as low as 5 muM within just 1 min of contact time.	Water	59-64	latexin	Homo sapiens	275-278
28160681-5	2017	In the presence of H2O2 at a dose of 20 muM, Fenton-driven chemical oxidation appeared to outplay the impediment of biodegradation caused by inhibited microbial activities in terms of removing total polycyclic aromatic hydrocarbons from the water column.	Water	241-246	latexin	Homo sapiens	40-43
28357801-4	2017	11.37 and 40% of phreatic water samples are categorized as NO3-N and NH4-N pollution in accordance with the WHO standards.	Water	26-31	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
27770326-0	2017	Aspirin and paracetamol removal using a commercial micro-sized TiO2 catalyst in deionized and tap water.	Water	98-103	SEC14 like lipid binding 2	Homo sapiens	94-97
27770326-4	2017	The research started from model systems with a single pollutant to the mixture of them and finally by moving from deionized water to tap water.	Water	137-142	SEC14 like lipid binding 2	Homo sapiens	133-136
28357801-6	2017	The results indicate NO3-N predominates in the shallow water and NH4-N predominates in the deep water for the single phreatic aquifer.	Water	55-60	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
28357792-4	2017	This protocol was first applied to mineral water spiked by GLY and AMPA at environmental concentration levels (25-750 ng L-1).	Water	43-48	immunoglobulin kappa variable 1-16	Homo sapiens	121-124
28084198-0	2017	Determination of Organophosphorous Pesticides in Environmental Water Samples Using Surface-Engineered C18 Functionalized Silica-Coated Core-Shell Magnetic Nanoparticles-Based Extraction Coupled with GC-MS/MS Analysis.	Water	63-68	Bardet-Biedl syndrome 9	Homo sapiens	102-105
28131981-0	2017	Interaction of the water soluble fraction of MSW-composts with Pb(II) and Cu(II) ions.	Water	19-24	submaxillary gland androgen regulated protein 3B	Homo sapiens	63-80
28131981-1	2017	In this study we report on the interactions between the water-soluble fraction (WSF) of two municipal solid waste composts (C1- and C2-WSF) with Pb(II) and Cu(II) ions at pH 4.5.	Water	56-61	submaxillary gland androgen regulated protein 3B	Homo sapiens	145-162
28452756-4	2017	The data hint at a decreased electrostatic interaction at higher pressure, presumably due to the increase of the dielectric constant of water by 3% and the decrease of the free volume at 300 bar.	Water	136-141	histidine triad nucleotide binding protein 1	Homo sapiens	9-13
27616430-3	2017	This work presented an effective approach to improve the water dispersibility, stability and even bioaccessibility of beta-carotene, using soy protein isolate (SPI) to perform as effective nanocarriers for this molecule.	Water	57-62	chromogranin A	Homo sapiens	160-163
26826013-0	2017	Is insulin diluted when stored in water?	Water	34-39	insulin	Homo sapiens	3-10
27616430-4	2017	RESULTS: The complexation with SPI remarkably improved the water dispersibility and stability against heating and freeze-drying of beta-carotene.	Water	59-64	chromogranin A	Homo sapiens	31-34
27616430-10	2017	CONCLUSION: SPI exhibits a good potential to perform as a nanocarrier for enhanced water dispersibility, stability and bioaccessibility of beta-carotene.	Water	83-88	chromogranin A	Homo sapiens	12-15
27898652-11	2017	CONCLUSIONS: Mineral-rich water ingestion may have a prime role on the activation of Sirt1 signaling and the modulation of glucocorticoid signaling in the postmenopause.	Water	26-31	sirtuin 1	Rattus norvegicus	85-90
28194573-2	2017	Aquaretics are drugs that promote free water excretion by blocking the arginine vasopressin receptor type 2 (AVPR2) in the collecting duct and thus impair urinary concentration.	Water	39-44	arginine vasopressin receptor 2	Homo sapiens	71-107
26826013-2	2017	In Uganda, patients were noted to store insulin vials by submerging them in water.	Water	76-81	insulin	Homo sapiens	40-47
28194573-2	2017	Aquaretics are drugs that promote free water excretion by blocking the arginine vasopressin receptor type 2 (AVPR2) in the collecting duct and thus impair urinary concentration.	Water	39-44	arginine vasopressin receptor 2	Homo sapiens	109-114
26826013-3	2017	OBJECTIVE: To examine whether withdrawing insulin from a vial without adding air back causes a vacuum which allows water to enter the vial, resulting in insulin dilution.	Water	115-120	insulin	Homo sapiens	42-49
28452367-2	2017	Herein, we report that diolefin-ruthenium complexes containing the chemically and redox non-innocent ligand trop2dad catalyse the production of H2 from formaldehyde and water in the presence of a base.	Water	169-174	tumor associated calcium signal transducer 2	Homo sapiens	108-113
27936472-1	2017	Sodium tanshinone IIA sulphonate, a water-soluble derivative of tanshinone IIA, has been proven to possess versatile biological properties, but its pharmacological effect on tracheal smooth muscle remains elusive.	Water	36-41	ATPase, class II, type 9A	Mus musculus	18-21
27921101-6	2017	Principal Component Analysis (PCA) revealed the model was heavily influenced by the anticoagulants in the case of dry samples, however, in aqueous whole blood samples, the effect was less pronounced as the water in the sample presumably diluted the amount of anticoagulant in contact with the ATR crystal.	Water	206-211	ATR serine/threonine kinase	Homo sapiens	293-296
28318264-12	2017	At polyelectrolyte concentrations &gt;10 mM, air-water interfaces are dominated by an excess of free PSS- polyelectrolytes and small amounts of PSS-/CTA+ complexes which, however, provide higher foam stabilities compared to CTAB free foams.	Water	49-54	PSS	Homo sapiens	101-104
28318264-12	2017	At polyelectrolyte concentrations &gt;10 mM, air-water interfaces are dominated by an excess of free PSS- polyelectrolytes and small amounts of PSS-/CTA+ complexes which, however, provide higher foam stabilities compared to CTAB free foams.	Water	49-54	PSS	Homo sapiens	144-147
28445755-5	2017	Particularly, the mutant Q4933A (or Q4863A in RyR2) critical for both the gating and Ryd binding not only has significantly less interaction with Ryd than the wild-type, but also yields more space for Ryd and water molecules in the cavity.	Water	209-214	ryanodine receptor 2	Homo sapiens	46-50
28406297-7	2017	This behavior can be accounted for by the special features of AChE, such as the presence of several subsites of different natures in the gorge or the existence of several water molecules that act as bridges in the electrostatic interactions.	Water	171-176	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-66
28432304-2	2017	The combination of the OPLS-AA (all atom) potential model of methanol and the widely used SPC/E water model has provided excellent agreement with measured X-ray diffraction data over the temperature range between 298 and 213 K, for mixtures with methanol molar fractions of 0.2, 0.3 and 0.4.	Water	96-101	proline rich protein gene cluster	Homo sapiens	90-93
28394615-1	2017	Influences of solvent molecules on SN2 reaction dynamics of microsolvated F-(H2O)n with CH3I, for n = 0-3, are uncovered by direct chemical dynamics simulations.	Water	77-80	solute carrier family 38 member 5	Homo sapiens	35-38
28383588-3	2017	We measured the Im chi(2) spectra of hemoglobin, myoglobin, serum albumin and lysozyme at the air/water interface in the CH and OH stretching regions using heterodyne-detected vibrational sum frequency generation (HD-VSFG) spectroscopy, and we deduced the isoelectric point of the protein by monitoring the orientational flip-flop of water molecules at the interface.	Water	98-103	lysozyme	Homo sapiens	78-86
27979093-5	2017	The water-holding capacity was markedly enhanced (p&lt;0.05) with the increase in both the size and content of SPI aggregates.	Water	4-9	chromogranin A	Homo sapiens	111-114
28529781-3	2017	The CoII atom is coordinated by two TMB anions and two water mol-ecules in the basal plane, while another water mol-ecule bridges the CoII atoms in the axial directions, forming polymeric chains running along [001].	Water	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28512575-1	2017	Multiple possibilities for the coordination of fac-[Re(CO)3(H2O)3]+ to a protein have been determined and include binding to Asp, Glu, Arg and His amino-acid residues as well as to the C-terminal carboxylate in the vicinity of Leu and Pro.	Water	60-63	FA complementation group C	Homo sapiens	47-50
28276244-4	2017	SET-LRP provides an ultrafast polymerization of a plethora of monomers (e.g., (meth)-acrylates, (meth)-acrylamides, styrene, and vinyl chloride) including hydrophobic and water insoluble to hydrophilic and water soluble.	Water	171-176	LDL receptor related protein 1	Homo sapiens	4-7
28276244-4	2017	SET-LRP provides an ultrafast polymerization of a plethora of monomers (e.g., (meth)-acrylates, (meth)-acrylamides, styrene, and vinyl chloride) including hydrophobic and water insoluble to hydrophilic and water soluble.	Water	206-211	LDL receptor related protein 1	Homo sapiens	4-7
29965143-4	2017	The results showed that the concentration gradient of both NO3-and NH4+ existed at the sediment-water interface.	Water	96-101	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
28394334-0	2017	Corrigendum: Ectopic expression of Arabidopsis Target of Rapamycin (AtTOR) improves water-use efficiency and yield potential in rice.	Water	84-89	target of rapamycin	Arabidopsis thaliana	68-73
29965143-5	2017	NO3- concentrations decreased from bottom water to pore water and NO3- was accumulated in sediments.	Water	42-47	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
29965143-5	2017	NO3- concentrations decreased from bottom water to pore water and NO3- was accumulated in sediments.	Water	56-61	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
29965144-3	2017	The result showed concentrations of OCPs in water ranged from 1.89 to 90.19 ng L-1 (mean 30.16 ng L-1), and concentrations of OCPs in sediments varied from 3.10 to 16.02 ng g-1 (average 8.58 ng g-1).	Water	44-49	immunoglobulin kappa variable 1-16	Homo sapiens	79-82
29965151-9	2017	When treating eutrophic lake water with a phosphate concentration of 2 mg L-1, the phosphate concentration level could meet the III rank of Surface Water Environment Quality Standard of China by adopting the dosage of zirconium modified diatomite &gt;=1.25 g L-1.	Water	29-34	L1 cell adhesion molecule	Homo sapiens	74-77
29965151-9	2017	When treating eutrophic lake water with a phosphate concentration of 2 mg L-1, the phosphate concentration level could meet the III rank of Surface Water Environment Quality Standard of China by adopting the dosage of zirconium modified diatomite &gt;=1.25 g L-1.	Water	148-153	L1 cell adhesion molecule	Homo sapiens	74-77
28131916-8	2017	Water-soluble antioxidant Trolox also prevented TNF-induced activation and permeability of endothelium in vitro via inhibition of NFkappaB signaling, suggesting that the protective action of the uncouplers is linked to their antioxidant potential.	Water	0-5	tumor necrosis factor	Mus musculus	48-51
28106930-1	2017	The electrochemical behavior of fac-[Mn(pdbpy)(CO)3 Br] (pdbpy=4-phenyl-6-(phenyl-2,6-diol)-2,2"-bipyridine) (1) in acetonitrile under Ar, and its catalytic performances for CO2 reduction with added water, 2,2,2-trifluoroethanol (TFE), and phenol are discussed in detail.	Water	199-204	FA complementation group C	Homo sapiens	32-35
28095360-2	2017	Warfarin, as one of the most effective anticoagulants, was designed and synthesized via lipase from porcine pancreas (PPL) as a biocatalyst to catalyze the Michael addition of 4-hydroxycoumarin to alpha, beta-unsaturated enones in organic medium in the presence of water.	Water	265-270	periplakin	Homo sapiens	118-121
28288513-0	2017	Dielectric Relaxation of Ice in Gelatin-Water Mixtures.	Water	40-45	carboxylesterase 2	Homo sapiens	25-28
28248453-0	2017	Nonmonotonic Hydration Behavior of Bovine Serum Albumin in Alcohol/Water Binary Mixtures: A Terahertz Spectroscopic Investigation.	Water	67-72	albumin	Homo sapiens	42-55
28287743-3	2017	We provide evidence for substantial enhancement (factor 4-230) of aqueous solubility of poorly water-soluble anionic drugs induced by low (0.1-5% (w/w)) concentration of EPO for a panel of seven acidic crystalline drugs.	Water	95-100	erythropoietin	Homo sapiens	170-173
28158469-8	2017	RESULTS: Increasing MIF expression in the NTS of 2K1C rats attenuated the development of hypertension, reversed the impairment of baroreflex function, and reduced the increase in water intake.	Water	179-184	macrophage migration inhibitory factor	Rattus norvegicus	20-23
28027428-4	2017	We found that the water extract of P. koraiensis pinecones exhibits significant cytotoxic activity, with IC50 values ranging from 0.62 to 1.73 mg/ml in four human lung cancer cell lines, A549, H1264, H1299, and Calu-6, irrespective of their p53 status.	Water	18-23	tumor protein p53	Homo sapiens	241-244
28371597-8	2017	Another protein that contributes to proton concentration increase in the extracellular space is tumor-specific HIF1alpha-dependent carbonic anhydrase IX, which generates a proton in the reaction between carbon dioxide and water.	Water	222-227	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-120
28088531-0	2017	The effect of dissolved organic matter on soybean peroxidase-mediated removal of triclosan in water.	Water	94-99	peroxidase	Glycine max	50-60
27417258-6	2017	The barrier properties of IB1 are immediate upon application and remain effective for at least 12 h. It is absorbed into the stratum corneum of the skin and remains there until rinsing with water, yet the ingredients are not absorbed into the body.	Water	190-195	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	26-29
28027428-5	2017	We also demonstrate that pinecone water extract induces apoptosis associated with caspase-3 activation in the same cancer cell lines.	Water	34-39	caspase 3	Homo sapiens	82-91
27754715-1	2017	PURPOSE: Although aquaporin 0 (AQP0) is a member of the AQP family, it has limited water permeability compared with other members.	Water	83-88	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	18-29
28135681-6	2017	In the presence of NO3- and CH3COO- (for synthesizing TFT-LCD wastewater), and F- and SO42- (for synthesizing semiconductor wastewater), CR% was lower than in pure water, although the ultimate PR% did not differ significantly.	Water	67-72	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
28152411-4	2017	PCDD/F and PCB concentrations in two surface water samples are relatively low, with the average concentrations of 0.038 and 0.001 pg WHO-TEQ/L (7.474 and 1.862 pg L-1), respectively.	Water	45-50	pyruvate carboxylase	Homo sapiens	11-14
30595866-2	2017	PURPOSE: Evaluation of superoxide dismutase (SOD) variations as an antioxidant enzyme (with a physiological role in the dismutation of highly reactive oxygen free radicals into oxygen and water) in young patients with cardiac arrhythmias.	Water	188-193	superoxide dismutase 1	Homo sapiens	23-43
30595866-2	2017	PURPOSE: Evaluation of superoxide dismutase (SOD) variations as an antioxidant enzyme (with a physiological role in the dismutation of highly reactive oxygen free radicals into oxygen and water) in young patients with cardiac arrhythmias.	Water	188-193	superoxide dismutase 1	Homo sapiens	45-48
28134709-5	2017	RECENT FINDINGS: MAGED2 mutations caused X-linked polyhydramnios with prematurity and a severe but transient form of antenatal Bartter"s syndrome.We distinguish two types of hereditary NDI: a "pure" type with loss of water only and a complex type with loss of water and ions.	Water	217-222	arginine vasopressin receptor 2	Homo sapiens	9-12
28134709-5	2017	RECENT FINDINGS: MAGED2 mutations caused X-linked polyhydramnios with prematurity and a severe but transient form of antenatal Bartter"s syndrome.We distinguish two types of hereditary NDI: a "pure" type with loss of water only and a complex type with loss of water and ions.	Water	260-265	arginine vasopressin receptor 2	Homo sapiens	9-12
28134709-6	2017	Mutations in the AVPR2 or AQP2 genes, encoding the vasopressin V2 receptor and the water channel Aquaporin2, respectively, lead to a "pure" NDI with loss of water but normal conservation of ions.	Water	83-88	arginine vasopressin receptor 2	Homo sapiens	17-22
28134709-6	2017	Mutations in the AVPR2 or AQP2 genes, encoding the vasopressin V2 receptor and the water channel Aquaporin2, respectively, lead to a "pure" NDI with loss of water but normal conservation of ions.	Water	83-88	arginine vasopressin receptor 2	Homo sapiens	140-143
27754715-1	2017	PURPOSE: Although aquaporin 0 (AQP0) is a member of the AQP family, it has limited water permeability compared with other members.	Water	83-88	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	31-35
27317656-5	2017	Exogenous human recombinant low-density lipoprotein receptor-related protein-1 protein reduced hematoma volume, brain water content surrounding hematoma, blood-brain barrier permeability and improved neurological function three days after intracerebral hemorrhage.	Water	118-123	LDL receptor related protein 1	Homo sapiens	28-78
28134709-6	2017	Mutations in the AVPR2 or AQP2 genes, encoding the vasopressin V2 receptor and the water channel Aquaporin2, respectively, lead to a "pure" NDI with loss of water but normal conservation of ions.	Water	157-162	arginine vasopressin receptor 2	Homo sapiens	17-22
28134709-6	2017	Mutations in the AVPR2 or AQP2 genes, encoding the vasopressin V2 receptor and the water channel Aquaporin2, respectively, lead to a "pure" NDI with loss of water but normal conservation of ions.	Water	157-162	arginine vasopressin receptor 2	Homo sapiens	51-74
28134709-6	2017	Mutations in the AVPR2 or AQP2 genes, encoding the vasopressin V2 receptor and the water channel Aquaporin2, respectively, lead to a "pure" NDI with loss of water but normal conservation of ions.	Water	157-162	arginine vasopressin receptor 2	Homo sapiens	140-143
28013161-0	2017	Development and evaluation of predictive model for bovine serum albumin-water partition coefficients of neutral organic chemicals.	Water	72-77	albumin	Homo sapiens	58-71
28013161-2	2017	In this study, we developed a new QSAR model for bovine serum albumin (BSA) - water partition coefficients (KBSA/W) of neutral organic chemicals with large structural variance, logKBSA/W values covering 3.5 orders of magnitude (1.19-4.76).	Water	78-83	albumin	Homo sapiens	56-69
27335015-6	2017	Its mass concentrations of 107 to 117 ng L-1 in three tap water samples were the highest of all herbicides measured in the drinking waters.	Water	58-63	immunoglobulin kappa variable 1-16	Homo sapiens	41-44
27335016-6	2017	Sum of mean concentrations of eight PFAAs detected in drinking tap water from Leipzig was 11.5 ng L-1, dominated by perfluorooctanoic acid (PFOA, 6.2 ng L-1).	Water	67-72	immunoglobulin kappa variable 1-16	Homo sapiens	98-101
27614102-7	2017	RESULTS: Water vapour transmission rate demonstrated that as the phosphatidylcholine acyl chain length increased from C14, to C18, to C22, there was a corresponding increase in occlusive character.	Water	9-14	Bardet-Biedl syndrome 9	Homo sapiens	126-129
28223469-5	2017	Most of these increases were significantly inhibited by either renal denervation performed at 8 weeks of age or treatment with an angiotensin-converting enzyme inhibitor, captopril, in drinking water starting at weaning.	Water	194-199	angiotensin I converting enzyme	Rattus norvegicus	130-159
27964896-8	2017	In the multivariable regress model, high water was closely associated with the MMSE score (Standardized Coefficient=-0.021) and cognitive impairment (arsenic  100 mug/L PR4/1=4.01).	Water	41-46	phospholipid phosphatase related 4	Homo sapiens	167-172
28154204-4	2017	The structures of the N-acyl chain and long-chain base (LCB) of the molecule were determined by MS4 on [M + H - H2O - (1-O-FA)]+ ions that yielded multiple sets of specific ions.	Water	112-115	clathrin, light polypeptide (Lcb)	Mus musculus	56-59
28507478-6	2017	Melatonin treatment (10 mg/kg, daily in drinking water for 6 months) in aged mice significantly attenuated the age-induced downregulation of SIRT1, FOXO1, MT1 and MT2 protein expression and attenuated the age-induced increase in p53, ac-p53, MDM2, and DKK1 protein and mRNA expression.	Water	49-54	metallothionein 1	Mus musculus	155-158
28117151-2	2017	Drinking water is a route of exposure for populations using water contaminated by PFAS discharges.	Water	9-14	phosphoribosylformylglycinamidine synthase	Homo sapiens	82-86
28117151-14	2017	In the treated water, total PFAS concentrations never exceeded 60ng/L.	Water	15-20	phosphoribosylformylglycinamidine synthase	Homo sapiens	28-32
28368309-5	2017	In this review, the pioneering SN1 approaches performed in pure water and in the absence of a metal based Lewis acid are compiled and discussed.	Water	64-69	solute carrier family 38 member 3	Homo sapiens	31-34
28152563-8	2017	Analysis of these transitions shows that the free energy change for urea- and guanidine hydrochloride-induced Phafin2 denaturation in water is ~4 kcal mol-1 .	Water	134-139	pleckstrin homology and FYVE domain containing 2	Homo sapiens	110-117
28153292-8	2017	The feasibility to directly determine parts-per-trillion concentration levels of PAHs after a very simple solid-phase extraction with C18 membranes is established with natural water samples containing uncalibrated constituents.	Water	176-181	Bardet-Biedl syndrome 9	Homo sapiens	134-137
28009898-0	2017	3D-QSAR predictions for bovine serum albumin-water partition coefficients of organic anions using quantum mechanically based descriptors.	Water	45-50	albumin	Homo sapiens	31-44
28507478-6	2017	Melatonin treatment (10 mg/kg, daily in drinking water for 6 months) in aged mice significantly attenuated the age-induced downregulation of SIRT1, FOXO1, MT1 and MT2 protein expression and attenuated the age-induced increase in p53, ac-p53, MDM2, and DKK1 protein and mRNA expression.	Water	49-54	metallothionein 2	Mus musculus	163-166
27978456-6	2017	The ability of these MNCPs for removing Pb(II) and Cd(II) from water and wastewater was studied, and the effects of different parameters (pH, adsorbent dosage, metal ion concentration, contact time and agitation) on the adsorption process were investigated.	Water	63-68	submaxillary gland androgen regulated protein 3B	Homo sapiens	40-57
28345058-2	2017	Nonrainfall waters (for example, fog and dew) are the least-studied and least-characterized components of the hydrological cycle, although they supply critical amounts of water for dryland ecosystems.	Water	12-17	zinc finger protein, FOG family member 1	Homo sapiens	33-36
28330341-9	2017	Neglecting other nanoscale effects which may influence the contact angle, the line tension of SPC/E (extended simple point charge model) water was calculated to be 3.6x10-11 N, which is also in good agreement with the previously calculated values.	Water	137-142	proline rich protein gene cluster	Homo sapiens	94-97
28248506-2	2017	Here, we report our systematic characterization of hydration dynamics around a beta-barrel protein, rat liver fatty acid-binding protein (rLFABP), to reveal the effect of different protein secondary structures on hydration water.	Water	223-228	fatty acid binding protein 1	Rattus norvegicus	138-144
27987451-6	2017	Optimal conditions for removing As(III) and As(V) from water were established.	Water	55-60	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	44-49
28297654-2	2017	To date, most water conduction studies on AQP0 were performed on protein expressed in Xenopus oocytes, and the results may therefore also reflect effects introduced by the oocytes themselves.	Water	14-19	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	42-46
28225613-3	2017	To further investigate this issue and inspired by research in water oxidation, we calculate in the present study the dehydrogenation free energy of aqueous Co2+, which is the free energy change associated with the first step of the water oxidation reaction mechanism of recently investigated model Co(II)-aqua catalysts.	Water	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	298-303
28225613-3	2017	To further investigate this issue and inspired by research in water oxidation, we calculate in the present study the dehydrogenation free energy of aqueous Co2+, which is the free energy change associated with the first step of the water oxidation reaction mechanism of recently investigated model Co(II)-aqua catalysts.	Water	232-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	298-303
29965583-2	2017	It was shown in the results that after 30 d non-water starvation endurance, the effluent concentrations of NO3--N in sulfur/dolomite and pyrite/dolomite reactors increased from 1.78 mg L-1, 11.32 mg L-1 to 27.87 mg L-1, 26.56 mg L-1 respectively at the low temperature of 12-14C.	Water	48-53	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
28352627-2	2017	The free water retention is due to non-osmotic vasopressin secretion resulting from the cirrhosis-associated splanchnic vasodilatation.	Water	9-14	arginine vasopressin	Homo sapiens	47-58
28281634-6	2017	The results highlighted the synergistic effects of SPI, HNTs, PVA, and PTGE on the mechanical properties, water resistance, and thermal stability of SPI films, which showed excellent strength and flexibility.	Water	106-111	chromogranin A	Homo sapiens	149-152
27325577-5	2017	METHODS: Mice were fed with ovalbumin (OVA) in drinking water then epicutaneously sensitized by repeated application of OVA to tape-stripped skin.	Water	56-61	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	28-37
28111028-7	2017	In addition to small pores, the peritoneal membrane contains a specialized water channel, aquaporin 1, which is also present in capillaries of the peritoneal membrane.	Water	75-80	aquaporin 1 (Colton blood group)	Homo sapiens	90-101
28034894-5	2017	Herein, we hypothesized that hypo-osmotic stress following water ingestion modulates the eNOS/NO pathway, thereby alternating vascular resistance.	Water	59-64	nitric oxide synthase 3	Homo sapiens	89-93
28034894-13	2017	CONCLUSIONS: The hypo-osmotic stimulus of water ingestion increases angiopoietin-1 secretion and subsequently activates the Tie-2/Akt/eNOS signaling pathway in RBCs, thereby revealing a novel biological mechanism simultaneously occurring with the osmopressor response.	Water	42-47	AKT serine/threonine kinase 1	Homo sapiens	130-133
27900397-5	2017	Previous injections of NA (0.1 and 1 nmols) or Phen (0.1, 1 and 10 nmols) significantly enhanced the water intake elicited by the injection of ANG II into the SFO.	Water	101-106	angiotensinogen	Rattus norvegicus	143-149
28034894-13	2017	CONCLUSIONS: The hypo-osmotic stimulus of water ingestion increases angiopoietin-1 secretion and subsequently activates the Tie-2/Akt/eNOS signaling pathway in RBCs, thereby revealing a novel biological mechanism simultaneously occurring with the osmopressor response.	Water	42-47	nitric oxide synthase 3	Homo sapiens	134-138
28156033-0	2017	Amplification of a FRET Probe by Lipid-Water Partition for the Detection of Acid Sphingomyelinase in Live Cells.	Water	39-44	sphingomyelin phosphodiesterase 1	Homo sapiens	76-97
28534058-1	2017	BACKGROUND: Catalase enzyme is usually distributed in mammalian seminal plasma, where it decomposes hydrogen peroxide into water and oxygen and enhances sperm survivability.	Water	123-128	catalase	Homo sapiens	12-20
27900397-0	2017	Noradrenaline receptor mechanisms modulate the angiotensin II-induced water intake in the subfornical organ in rats.	Water	70-75	angiotensinogen	Rattus norvegicus	47-61
27900397-2	2017	Microinjection of ANG II (10 pmol, 50 nl) into the SFO caused a robust drinking response (water volume, 1.8-8.7 ml for 20 min).	Water	90-95	angiotensinogen	Rattus norvegicus	18-24
27550154-7	2017	Toxic and potential toxic elements Cr, As, Cd, Tl, Pb in water and Al, Cr, As, Hg, Tl in feed were significantly correlated with those in milk (p &lt; 0.05).	Water	57-62	Weaning weight-maternal milk	Bos taurus	138-142
27550154-8	2017	Results of correlation analysis revealed that elements in water and feed might contribute to the elements in milk.	Water	58-63	Weaning weight-maternal milk	Bos taurus	109-113
26919570-1	2017	The astrocytic water channel proteins aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are known to be altered in brains affected by several neurodegenerative disorders, including Alzheimer"s disease.	Water	15-20	aquaporin 1 (Colton blood group)	Homo sapiens	38-49
26919570-1	2017	The astrocytic water channel proteins aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are known to be altered in brains affected by several neurodegenerative disorders, including Alzheimer"s disease.	Water	15-20	aquaporin 1 (Colton blood group)	Homo sapiens	51-55
28012384-0	2017	Simultaneous removal of As(V) and Cr(VI) from water by macroporous anion exchanger supported nanoscale hydrous ferric oxide composite.	Water	46-51	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-29
28012384-8	2017	Fixed-bed treatment of As(V)/Cr(VI) binary synthetic water by HFO-201 resulted in elimination of As (from 1.0 to below 0.01 mg/L) and Cr (from 5.0 to below 0.05 mg/L), with the treatment capacity of 1700 bed volume (BV).	Water	53-58	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-28
27932595-9	2017	CONCLUSION: These results demonstrate that hygiene practices and livestock water management are correlated with acute malnutrition in Sila, Chad.	Water	75-80	chondroadherin	Homo sapiens	140-144
28199208-8	2017	Moreover, the water and fodder consumption were significantly improved by MIF siRNA treatment.	Water	14-19	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	74-77
27893932-6	2017	In this conceptual model, the density of rain is increased by solution of surface salts, transporting near-surface oxygenated NO3- bearing water downward where it encounters reducing conditions and mixes with oxygen-free ascending geologic brines.	Water	139-144	NBL1, DAN family BMP antagonist	Homo sapiens	126-129
27935709-6	2017	The incorporation of curcumin into oil-in-water emulsions (30% MCT, 1 mg curcumin/g MCT, d32   298 nm) improved its water dispersibility and chemical stability.	Water	116-121	solute carrier family 16 member 1	Homo sapiens	63-69
27324750-6	2017	The consumption of water during nebulization was acceptable, being 180 L ha-1 min-1 , which lasted an average of about 1 min to reduce the temperature below the threshold value of 30  C. A total of 85-90 hL (from 0.8 to 0.9 mm) of water per hectare per day was required.	Water	19-24	Rho GTPase activating protein 45	Homo sapiens	73-83
28128939-5	2017	SP3+ ions adapt to the smaller size droplet through small conformational changes that result in coiling of the hydrophobic C-terminus of the peptide on or near the droplet surface, intramolecular interactions involving the hydrophilic N-terminus of the peptide, and water-mediated interactions between the SP3+ ion and H3O+ and Cl- ions.	Water	266-271	Sp3 transcription factor	Homo sapiens	0-3
28271365-4	2017	The new sequence was tested on lysozyme and bovine pancreatic trypsin inhibitor (BPTI), demonstrating its efficiency in both water suppression and, more excitingly, preserving water-proximate biomolecular resonances in omega2.	Water	125-130	trophoblast Kunitz domain protein 1	Bos taurus	62-79
28271365-4	2017	The new sequence was tested on lysozyme and bovine pancreatic trypsin inhibitor (BPTI), demonstrating its efficiency in both water suppression and, more excitingly, preserving water-proximate biomolecular resonances in omega2.	Water	176-181	trophoblast Kunitz domain protein 1	Bos taurus	62-79
28253085-3	2017	To the best of our knowledge, no study to date has evaluated the effects of water pipe smoking on cytochrome P450 (CYP450) activities and drug interaction potential in humans, whereas only limited information is available on the impact of secondhand smoke on drug metabolism.	Water	76-81	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-113
28253085-11	2017	Further studies in larger prospective samples are recommended to evaluate water pipe and secondhand tobacco smoke effects on CYP450 function, particularly at higher smoke exposure conditions.	Water	74-79	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	125-131
28336818-5	2017	When challenged with water deprivation, animals exposed to 0.15 mol/L NaCl during early life showed impaired water intake, reduced salt preference ratio, and vasopressin (AVP) secretion.	Water	21-26	arginine vasopressin	Rattus norvegicus	158-169
27090529-1	2017	In peritoneal dialysis (PD), ultrafiltration (UF) volume is the sum of solute-free- and solute-coupled-water removal, a dynamic process throughout the entire dwell exerted via aquaporin-1 (AQP1) and small pores, respectively.	Water	103-108	aquaporin 1 (Colton blood group)	Homo sapiens	176-187
28107951-10	2017	Furthermore, no unfolding was observed during the dissolution process of cytochrome c in water.	Water	89-94	cytochrome c, somatic	Homo sapiens	73-85
28094471-3	2017	The desorption rate of water molecules increases from 10 to 18 mg min-1 , while the diameters of polyacrylonitrile fibers reduce from 1.02 to 0.14 microm.	Water	23-28	CD59 molecule (CD59 blood group)	Homo sapiens	66-71
28107951-15	2017	Insulin underwent observable unfolding when water was used for dissolution.	Water	44-49	insulin	Homo sapiens	0-7
28249415-10	2017	In contrast, the use of a classical Na-O Lennard-Jones potential with SPC/E water accurately predicts the Na-O distance as 2.39 A although the Na-O peak is over-structured with respect to experiment.	Water	76-81	proline rich protein gene cluster	Homo sapiens	70-73
28272038-7	2017	Studies reveal that 6 mg/ml GPA-2 is able to effect a 100% removal of organic impurities - chlorophenol (50 ppm) and phthalic anhydride (70 ppm) - from water, while complete removal of the heavy metal ions (Cu+2, Co+2 and Cd+2) together at 30 ppm concentration has been achieved with 7.5 mg/ml GPA-2.	Water	152-157	glycoprotein hormone subunit alpha 2	Homo sapiens	28-33
28293084-0	2017	Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression.	Water	14-19	heme oxygenase 1	Mus musculus	129-145
28179567-5	2017	One mechanism in the model plant Arabidopsis thaliana studied here comprises irreversible inhibition of RD21"s activity by Serpin1, whereas the other mechanism is a result of the reversible inhibition of RD21 activity by a Kunitz protease inhibitor named water-soluble chlorophyll-binding protein (WSCP).	Water	255-260	Granulin repeat cysteine protease family protein	Arabidopsis thaliana	204-208
28107010-5	2017	With the dispersion parameters optimized to phase compositions, the BK3 and GCP models were able to represent the CO2 solubility in water, however, the water composition in CO2-rich phase is systematically underestimated.	Water	132-137	golgin B1	Homo sapiens	76-79
28128570-5	2017	In this study, we calculated potentials of mean force for water, ammonia, urea, molecular oxygen, and methanol across the urea transporter B (UT-B) and aquaporin-1 (AQP1), using 3D-RISM, as well as using MD simulations and umbrella sampling.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	152-163
28128570-5	2017	In this study, we calculated potentials of mean force for water, ammonia, urea, molecular oxygen, and methanol across the urea transporter B (UT-B) and aquaporin-1 (AQP1), using 3D-RISM, as well as using MD simulations and umbrella sampling.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	165-169
28230163-0	2017	Ectopic expression of Arabidopsis Target of Rapamycin (AtTOR) improves water-use efficiency and yield potential in rice.	Water	71-76	target of rapamycin	Arabidopsis thaliana	55-60
28104434-2	2017	The present study was performed to investigate effects and underlying mechanism of central injected opiorphin on food intake and water intake in mice.	Water	129-134	opiorphin prepropeptide	Homo sapiens	100-109
28104434-8	2017	Interestingly, the effect of opiorphin on water intake was increased in both fasted and freely feeding mice, which was completely blocked by captopril and valsartan.	Water	42-47	opiorphin prepropeptide	Homo sapiens	29-38
28104434-10	2017	All together, the food and water intake effects of opiorphin may be due to the protection of the endogenous angiotensin and opioid peptides from degradation by NEP or APN.	Water	27-32	opiorphin prepropeptide	Homo sapiens	51-60
28128371-1	2017	We report herein the efficient hydro-oxycarbonylation of symmetrical and unsymmetrical internal alkynes with carboxylic acids in water at 60  C, employing the catalytic system [AuCl(PPh3)]/AgOAc (5 mol%).	Water	129-134	caveolin 1	Homo sapiens	182-186
28220853-0	2017	Successive extraction of As(V), Cu(II) and P(V) ions from water using spent coffee powder as renewable bioadsorbents.	Water	58-63	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	25-30
28220853-1	2017	For the first time, renewable and easy accessible pre-bleached spent coffee powder coated with polyethylenimine (PEI) and ferric ions (Coffee-PEI-Fe) was used for the successive adsorption of As(V), Cu(II) and P(V) ions from spiked water samples.	Water	232-237	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	192-197
28151687-0	2017	Transient Phase of Ice Observed by Sum Frequency Generation at the Water/Mineral Interface During Freezing.	Water	67-72	carboxylesterase 2	Homo sapiens	19-22
28151687-1	2017	We observed a transient noncentrosymmetric phase of ice at water/mineral interfaces during freezing, which enhanced the intensity of the IR-visible sum frequency generation intensity by up to 20-fold.	Water	59-64	carboxylesterase 2	Homo sapiens	52-55
28361577-2	2017	Rats were fed ad libitum with normal tap water or tap water with extract of N. sativa seed, Ramaria condensata, Lactarius salmonicolor, Lactarius piperatus, and Tricholoma terreum for 3 days.	Water	54-59	nuclear RNA export factor 1	Rattus norvegicus	50-53
28151687-3	2017	Since the most stable form of ice, hexagonal and cubic ice, are centrosymmetric, our study suggests the transient existence of stacking-disordered ice during the freezing process at water/mineral interfaces.	Water	182-187	carboxylesterase 2	Homo sapiens	30-33
28151687-3	2017	Since the most stable form of ice, hexagonal and cubic ice, are centrosymmetric, our study suggests the transient existence of stacking-disordered ice during the freezing process at water/mineral interfaces.	Water	182-187	carboxylesterase 2	Homo sapiens	55-58
28151687-3	2017	Since the most stable form of ice, hexagonal and cubic ice, are centrosymmetric, our study suggests the transient existence of stacking-disordered ice during the freezing process at water/mineral interfaces.	Water	182-187	carboxylesterase 2	Homo sapiens	55-58
28007386-2	2017	The concentrations of PAHs in the surface water samples ranged from 1.7 to 2.8ngl-1 and from 0.04 to 59.6ngl-1 in pre- and postmonsoon, respectively.	Water	42-47	leucine rich repeat containing 4C	Homo sapiens	78-83
28127614-2	2017	We show experimentally that our pump operates in almost deionized water for periods exceeding 24 h and induces fluid flows of mum s-1 over hundreds of mum.	Water	66-71	latexin	Homo sapiens	126-129
28127614-2	2017	We show experimentally that our pump operates in almost deionized water for periods exceeding 24 h and induces fluid flows of mum s-1 over hundreds of mum.	Water	66-71	latexin	Homo sapiens	151-154
28165084-0	2017	Unbinding of fluorinated oxime drug from the AChE gorge in polarizable water: a well-tempered metadynamics study.	Water	71-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-49
28165084-3	2017	We systematically studied the unbinding of fluorinated obidoxime (FOBI) and non-fluorinated obidoxime (OBI) from the active site gorge of the serine hydrolase AChE in mean field polarizable water by employing all atom molecular dynamics simulations.	Water	190-195	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-163
28201892-0	2017	Reverse Monte Carlo modeling of liquid water with the explicit use of the SPC/E interatomic potential.	Water	39-44	proline rich protein gene cluster	Homo sapiens	74-77
28201892-1	2017	Reverse Monte Carlo (RMC) modeling of liquid water, based on one neutron and one X-ray diffraction data set, applying also the most popular interatomic potential for water, extended simple point charge (SPC/E), has been performed.	Water	45-50	proline rich protein gene cluster	Homo sapiens	203-206
28201892-2	2017	The strictly rigid geometry of SPC/E water molecules had to be loosened somewhat, in order to be able to produce a good fit to both sets of experimental data.	Water	37-42	proline rich protein gene cluster	Homo sapiens	31-34
28024260-4	2017	The oligomerization process of insulin during development of pharmaceutical formulation with routinely used excipients has been studied using translation diffusion coefficient Dix10-10m2s-1 established in water solution.	Water	205-210	insulin	Homo sapiens	31-38
27998655-2	2017	Through chemical and molecular biology analysis, the results showed that the total concentrations of sulfonamides and tetracyclines were in the range 62.0-373.8ngL-1 and 0.2-259.1ngL-1 respectively in water samples, and in the range 0.19-1.59ngg-1 dry weight and 3.45-74.84ngg-1 dry weight respectively, in sediments samples.	Water	201-206	leucine rich repeat containing 4C	Homo sapiens	160-165
28198447-8	2017	Etanercept treatment of old mice reversed these changes, suggesting that age-related changes in TNFalpha expression are an important regulator of mucosal 5-HT signalling and pellet output and water content in old mice.	Water	192-197	tumor necrosis factor	Mus musculus	96-104
28124697-3	2017	In this work, we investigate the adsorption onto a gold surface, in water, of an amyloid-beta (Abeta) peptide, which is the amyloidogenic peptide involved in Alzheimer"s disease.	Water	68-73	amyloid beta precursor protein	Homo sapiens	95-100
28124697-7	2017	Finally, relaxation of the Abeta conformations at the gold/water interface is performed by a 19 mus Hamiltonian-temperature replica exchange MD simulation.	Water	59-64	amyloid beta precursor protein	Homo sapiens	27-32
28228725-2	2017	The water-soluble CORM-A1 reduced apoptosis and NADPH oxidase (NOX)-derived reactive oxygen species (ROS) induced by tumor necrosis factor (TNF)-alpha/cycloheximide (CHX) in mouse MODE-K intestinal epithelial cells (IECs), without influencing TNF-alpha/CHX-induced mitochondrial superoxide anion ([Formula: see text]).	Water	4-9	tumor necrosis factor	Mus musculus	117-138
28228725-2	2017	The water-soluble CORM-A1 reduced apoptosis and NADPH oxidase (NOX)-derived reactive oxygen species (ROS) induced by tumor necrosis factor (TNF)-alpha/cycloheximide (CHX) in mouse MODE-K intestinal epithelial cells (IECs), without influencing TNF-alpha/CHX-induced mitochondrial superoxide anion ([Formula: see text]).	Water	4-9	tumor necrosis factor	Mus musculus	140-150
27932503-9	2017	The final scenario has AQP1 primarily in the proximal duct cells which secrete water under baseline conditions.	Water	79-84	aquaporin 1 (Colton blood group)	Homo sapiens	23-27
28228725-2	2017	The water-soluble CORM-A1 reduced apoptosis and NADPH oxidase (NOX)-derived reactive oxygen species (ROS) induced by tumor necrosis factor (TNF)-alpha/cycloheximide (CHX) in mouse MODE-K intestinal epithelial cells (IECs), without influencing TNF-alpha/CHX-induced mitochondrial superoxide anion ([Formula: see text]).	Water	4-9	tumor necrosis factor	Mus musculus	243-252
28178789-0	2017	Corresponding-states behavior of SPC/E-based modified (bent and hybrid) water models.	Water	72-77	proline rich protein gene cluster	Homo sapiens	33-36
28178789-3	2017	Molecular models of water, such as SPC/E, are needed for this purpose, and they have proved to capture many important features of real water.	Water	20-25	proline rich protein gene cluster	Homo sapiens	35-38
28178789-3	2017	Molecular models of water, such as SPC/E, are needed for this purpose, and they have proved to capture many important features of real water.	Water	135-140	proline rich protein gene cluster	Homo sapiens	35-38
28055215-4	2017	On the other hand, Salecan tuned the water content and the water release rate of the obtained hydrogel, leading to a controllable release rate of the insulin.	Water	37-42	insulin	Homo sapiens	150-157
28055215-4	2017	On the other hand, Salecan tuned the water content and the water release rate of the obtained hydrogel, leading to a controllable release rate of the insulin.	Water	59-64	insulin	Homo sapiens	150-157
27359349-0	2017	Claudin-2-mediated cation and water transport share a common pore.	Water	30-35	claudin 2	Canis lupus familiaris	0-9
27359349-2	2017	Former studies revealed that claudin-2 forms paracellular channels for small cations like sodium and potassium and also paracellular channels for water.	Water	146-151	claudin 2	Canis lupus familiaris	29-38
27359349-3	2017	This study analyses whether the diffusive transport of sodium and water occurs through a common pore of the claudin-2 channel.	Water	66-71	claudin 2	Canis lupus familiaris	108-117
27359349-10	2017	CONCLUSION: Our results indicate that claudin-2-mediated cation and water transport are frictionally coupled and share a common pore.	Water	68-73	claudin 2	Canis lupus familiaris	38-47
28179232-10	2017	Combining this approach with the systemic deletion of AMPKalpha1 we achieved reduced renal AMPK activity, accompanied by a shift to a moderate water- and salt-wasting phenotype.	Water	143-148	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	54-64
27852737-7	2017	Water-restricted, wild-type mice showed an increase in vasopressin and aldose reductase mRNA, sorbitol, fructose and uric acid in the supraoptic nucleus.	Water	0-5	arginine vasopressin	Homo sapiens	55-66
27883913-5	2017	Underground mine water and leachate contained higher mean concentrations (mug L-1) of Cu (9470), Co (3430) and Ni (590) compared with background concentrations (mug L-1) in un contaminated water of 1.9, 0.21 and 0.67 for Cu, Co and Ni respectively.	Water	17-22	immunoglobulin kappa variable 1-16	Homo sapiens	78-81
27979921-1	2017	Mitochondrial cytochrome c oxidase (CcO) transfers electrons from cytochrome c (Cyt.c) to O2 to generate H2O, a process coupled to proton pumping.	Water	105-108	cytochrome c, somatic	Homo sapiens	14-26
27979921-1	2017	Mitochondrial cytochrome c oxidase (CcO) transfers electrons from cytochrome c (Cyt.c) to O2 to generate H2O, a process coupled to proton pumping.	Water	105-108	cytochrome c, somatic	Homo sapiens	66-78
27979921-1	2017	Mitochondrial cytochrome c oxidase (CcO) transfers electrons from cytochrome c (Cyt.c) to O2 to generate H2O, a process coupled to proton pumping.	Water	105-108	cytochrome c, somatic	Homo sapiens	80-85
28025000-4	2017	Water-soluble vitamins B1, B2, B3 (nicotinamide), B5, B9 and fat-soluble vitamin E (alpha-tocopherol) were routinely detected in tears and blood serum while fat-soluble vitamin A (retinol) was detected only in blood serum.	Water	0-5	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	23-33
28120195-1	2017	gamma-Glutamyltranspeptidase (GGT) catalyzes the cleavage of gamma-glutamyl compounds and the transfer of gamma-glutamyl moiety to water or to amino acid/peptide acceptors.	Water	131-136	membrane bound gamma-glutamyltranspeptidase	Bacillus subtilis subsp. subtilis str. 168	30-33
27118686-0	2017	Spectroscopic investigation of water-soluble alloyed QDs with bovine serum albumin.	Water	31-36	albumin	Homo sapiens	69-82
27118686-1	2017	We present here a systematic investigation on the interaction between a water-soluble alloyed semiconductor quantum dot and bovine serum albumin using various spectroscopic techniques i.e. fluorescence quenching, resonance light scattering and synchronous fluorescence spectroscopy.	Water	72-77	albumin	Homo sapiens	131-144
27889934-11	2017	Follow-up experiments indicate that Ankrd23 mRNA level was increased 14-fold in cannulated gastrocnemius FA when intraluminal pressure was increased from 90 and 180 cm H2O for 4 hours.	Water	168-171	ankyrin repeat domain 23	Mus musculus	36-43
28510040-1	2017	Here I review the molecular mechanisms by which water-soluble monomeric amyloid-beta (Abeta) peptides are transformed into well-organized supramolecular complexes called amyloid fibrils.	Water	48-53	amyloid beta precursor protein	Homo sapiens	86-91
27507631-6	2017	CD101 exhibited &lt;2% degradation after long-term storage at 40  C as a lyophilized powder (9 months) and at room temperature in 5% dextrose (15 months), 0.9% saline (12 months) and sterile water (18 months).	Water	191-196	CD101 molecule	Homo sapiens	0-5
28254043-0	2017	Adsorption of Co(II) from aqueous solutions by water treatment residuals.	Water	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
28254043-1	2017	A study on the removal of Co(II) from aqueous solutions by water treatment residuals (WTR) was conducted in batch conditions.	Water	59-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
29744302-3	2017	The reduction of TCE under 90 mA current, 1 mL min-1 flow rate, and 1 mg L-1 initial TCE concentration, was inhibited in the presence of humic acids due to competition for direct electron transfer and/or reaction with atomic hydrogen produced at the cathode surface by water electrolysis.	Water	269-274	immunoglobulin kappa variable 1-16	Homo sapiens	73-76
28151443-2	2017	The radon concentrations were in the range of 3.56-98.57, 0.88-25.49, 0.73-1.35 and 0.24-1.03 Bq.L-1 for borehole, well, packaged and utility water, respectively.	Water	142-147	immunoglobulin kappa variable 1-16	Homo sapiens	97-100
27852737-9	2017	With water restriction, vasopressin in the pituitary of wild-type mice was significantly less than that of fructokinase-knockout mice, indicating that fructokinase-driven vasopressin secretion overrode synthesis.	Water	5-10	arginine vasopressin	Homo sapiens	24-35
27852737-15	2017	NEW &amp; NOTEWORTHY: This study increases our understanding of the mechanisms leading to vasopressin release under conditions of water restriction (acute dehydration).	Water	130-135	arginine vasopressin	Homo sapiens	90-101
27852737-17	2017	Nevertheless, mice undergoing water restriction remain capable of maintaining sufficient vasopressin (copeptin) levels to allow normal urinary concentration.	Water	30-35	arginine vasopressin	Homo sapiens	89-100
27887832-0	2017	Perfluoroalkyl acids (PFAAs) in the Pra and Kakum River basins and associated tap water in Ghana.	Water	82-87	SEC14 like lipid binding 2	Homo sapiens	78-81
28242818-1	2017	Collecting duct (CD) endothelin-1 (ET-1) is an autocrine inhibitor of Na+ and water reabsorption.	Water	78-83	endothelin 1	Homo sapiens	21-33
28242818-1	2017	Collecting duct (CD) endothelin-1 (ET-1) is an autocrine inhibitor of Na+ and water reabsorption.	Water	78-83	endothelin 1	Homo sapiens	35-39
28242818-2	2017	Salt or water loading increases CD ET-1 production; this is likely due, at least in part, to increased tubule fluid flow.	Water	8-13	endothelin 1	Homo sapiens	35-39
28242818-10	2017	Based on these and previously published findings, we present a comparison of flow-stimulated CD ET-1 production between CCD and IMCD We suggest that flow-stimulated CCD ET-1 production may be more involved in responding to Na+ delivery, while IMCD ET-1 production may be more responsive to water and solute delivery; the responsible pathways for mediating these effects in the two regions of the CD appear to be substantially distinct from one another.	Water	290-295	endothelin 1	Homo sapiens	169-173
28242818-10	2017	Based on these and previously published findings, we present a comparison of flow-stimulated CD ET-1 production between CCD and IMCD We suggest that flow-stimulated CCD ET-1 production may be more involved in responding to Na+ delivery, while IMCD ET-1 production may be more responsive to water and solute delivery; the responsible pathways for mediating these effects in the two regions of the CD appear to be substantially distinct from one another.	Water	290-295	endothelin 1	Homo sapiens	169-173
27887832-7	2017	The mean concentrations of  PFAAs in the Kakum and Pra Rivers were 281 and 398ng/L, while tap water (supplied from the treatment of water from those rivers) contained concentrations of 197 and 200ng/L, respectively.	Water	94-99	SEC14 like lipid binding 2	Homo sapiens	90-93
27847182-11	2017	In addition, the similarity of the temporal variations of the regional average of pH, NH4-N, and NO3-N concentrations in groundwater with those in the Yangtze River at the outlet of the Three Gorges Reservoir (TGR) suggests that the variations of these parameters in the WJHP is partly due to water storage by the TGR.	Water	127-132	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
27887832-9	2017	The risk quotient (RQ) attributed to drinking of tap water was estimated at 1.01 and 1.74 for PFOA and PFOS, respectively.	Water	53-58	SEC14 like lipid binding 2	Homo sapiens	49-52
28146084-3	2017	Aquaporin 1 (AQP1) is a small hydrophobic integral transmembrane protein with a predominant role in trans-cellular water transport.	Water	115-120	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
28061027-0	2017	Insights into the Oxidation Mechanism of sp2-sp3 Hybrid Carbon Materials: Preparation of a Water-Soluble 2D Porous Conductive Network and Detectable Molecule Separation.	Water	91-96	Sp2 transcription factor	Homo sapiens	41-44
28061027-0	2017	Insights into the Oxidation Mechanism of sp2-sp3 Hybrid Carbon Materials: Preparation of a Water-Soluble 2D Porous Conductive Network and Detectable Molecule Separation.	Water	91-96	Sp3 transcription factor	Homo sapiens	45-48
28146084-3	2017	Aquaporin 1 (AQP1) is a small hydrophobic integral transmembrane protein with a predominant role in trans-cellular water transport.	Water	115-120	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
28125062-4	2017	This was done to qualitatively improve the apparent ion-lipid binding constants obtained from simulations with the original force field (Berger lipids and GROMOS87 ions in combination with the SPC water model) in comparison to experimental data.	Water	197-202	proline rich protein gene cluster	Homo sapiens	193-196
28026940-6	2017	Additionally, while these substitutions modulate PON1"s active site shape, volume, and loop flexibility, their largest effect is in altering the solvent accessibility of the active site by expanding the active site volume, allowing additional water molecules to enter.	Water	243-248	paraoxonase 1	Homo sapiens	49-53
28039837-3	2017	The crystal structure of a potent inhibitor bound to the active CDK2/cyclin A complex revealed that the biphenyl substituent at position 5 of the pyrazolo[1,5-a]pyrimidine scaffold was located in a previously unexplored pocket and that six water molecules resided in the active site.	Water	240-245	cyclin A2	Homo sapiens	69-77
27966811-1	2017	Visible-light irradiation of a ternary hybrid catalyst prepared by grafting a dye, an H2 evolving CoIII catalyst and a CO-producing ReI catalyst on TiO2 have been found to produce both H2 and CO (syngas) in CO2 -saturated N,N-dimethyl formamide (DMF)/water solution containing a 0.1 m sacrificial electron donor.	Water	251-256	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	98-103
28103989-5	2017	Then the PRP of the two groups was activated in water bath at 37 C for 1 h. The formation time of PRG was recorded, and the formation situation of PRG was observed within 1 hour of activation.	Water	48-53	prion protein	Homo sapiens	9-12
28067397-2	2017	This complex promoted chemical and photochemical water oxidation efficiently with turnover frequencies of 0.28 s-1 and 5 min-1, respectively.	Water	49-54	CD59 molecule (CD59 blood group)	Homo sapiens	121-126
27924329-4	2017	The water matrix used was a simulated secondary effluent doped with 200 mug L-1 of the pesticide acetamiprid (ACTM) due to its recalcitrant nature.	Water	4-9	immunoglobulin kappa variable 1-16	Homo sapiens	76-79
27701016-4	2017	Insulin incorporation into the HII systems shrank the cylinders as it competed with the lipids in water-bonding.	Water	98-103	insulin	Homo sapiens	0-7
28001158-3	2017	Here, we focus on the mechanism of a water-head-driven oscillator and analyze the functions of its flow-switching period (T) and flow rate (Q) in a wide range (0.1 s-5.9 h and 2 muL min-1-2 mL min-1).	Water	37-42	CD59 molecule (CD59 blood group)	Homo sapiens	182-189
28001158-3	2017	Here, we focus on the mechanism of a water-head-driven oscillator and analyze the functions of its flow-switching period (T) and flow rate (Q) in a wide range (0.1 s-5.9 h and 2 muL min-1-2 mL min-1).	Water	37-42	CD59 molecule (CD59 blood group)	Homo sapiens	182-187
27611473-9	2017	The small molecules regulated dual-functional platform based on UCNPs/AuNPs is a simple, label-free method and can be applied for the turn-on fluorescence detection of AChE activity in human serum and Cd2+ in real water samples.	Water	214-219	acetylcholinesterase (Cartwright blood group)	Homo sapiens	168-172
28098196-2	2017	Here, HFO nanoparticles with carboxymethyl cellulose (CMC) or starch as modifier was synthesized for the purpose of stability improvement and As(V) removal from water.	Water	161-166	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	142-147
27916130-3	2017	Under the established conditions, the detection and quantification limits were 0.002 mug L-1 and 0.007 mug L-1 by using 5 mL of waste water and the intra- and inter-day relative standard deviations were less than 10.2% at concentrations of 0.02 and 0.1 mug L-1.	Water	134-139	immunoglobulin kappa variable 1-16	Homo sapiens	107-110
27916130-3	2017	Under the established conditions, the detection and quantification limits were 0.002 mug L-1 and 0.007 mug L-1 by using 5 mL of waste water and the intra- and inter-day relative standard deviations were less than 10.2% at concentrations of 0.02 and 0.1 mug L-1.	Water	134-139	immunoglobulin kappa variable 1-16	Homo sapiens	107-110
27916130-5	2017	Hydrazine was detected over a concentration range of 0.011-0.074 mug L-1 in 5 of 20 waste water samples.	Water	90-95	immunoglobulin kappa variable 1-16	Homo sapiens	69-72
27958733-4	2017	The additional water molecules can stabilize the transition states and the product complexes, and we infer that adding more water molecules in the reactions mainly act as solvent and promoting to form the methylamine nitrate (CH3NH3+NO3-).	Water	15-20	NBL1, DAN family BMP antagonist	Homo sapiens	233-236
27886764-3	2017	In this work, a simple and practical method is reported for the first time for the sensitive and selective colorimetric assay of ALP activity by exploiting a water-soluble Cu(II)-phenanthroline complex as the probe, on the basis of the distinctive metal-to-ligand charge-transfer (MLCT) properties.	Water	158-163	alkaline phosphatase, placental	Homo sapiens	129-132
28102983-0	2017	Diseases Associated With Exposure to Contaminants in the Water Supply at Camp Lejeune.	Water	57-62	cathelicidin antimicrobial peptide	Homo sapiens	73-77
27958733-4	2017	The additional water molecules can stabilize the transition states and the product complexes, and we infer that adding more water molecules in the reactions mainly act as solvent and promoting to form the methylamine nitrate (CH3NH3+NO3-).	Water	124-129	NBL1, DAN family BMP antagonist	Homo sapiens	233-236
28005365-6	2017	Dendritic PEGylated TAM radicals, TNP1 and TNP2, have higher water solubility and lower susceptibility for self-aggregation than their linear analogues TPP1 and TPP2.	Water	61-66	transition protein 2	Mus musculus	43-47
28081165-3	2017	We hypothesized that ADPKD patients have a more severely impaired urine concentrating capacity in comparison to other patients with chronic kidney disease at a similar level of kidney function, with consequently an enhanced AVP response to water deprivation with higher circulating AVP concentrations.	Water	240-245	arginine vasopressin	Homo sapiens	224-227
28068769-3	2017	Here, we develop a high-resolution CG force field for hydrated polyphenylene oxide/trimethylamine chloride (PPO/TMACl) membranes compatible with the mW water model using a hierarchical parametrization approach based on Uncertainty Quantification and reference atomistic simulations modeled with the Generalized Amber Force Field (GAFF) and TIP4P/2005 water.	Water	152-157	protoporphyrinogen oxidase	Homo sapiens	108-111
28068769-3	2017	Here, we develop a high-resolution CG force field for hydrated polyphenylene oxide/trimethylamine chloride (PPO/TMACl) membranes compatible with the mW water model using a hierarchical parametrization approach based on Uncertainty Quantification and reference atomistic simulations modeled with the Generalized Amber Force Field (GAFF) and TIP4P/2005 water.	Water	351-356	protoporphyrinogen oxidase	Homo sapiens	108-111
28068769-9	2017	The CG model of hydrated PPO/TMACl water is about 100 times faster than the reference atomistic GAFF-TIP4P/2005 model.	Water	35-40	protoporphyrinogen oxidase	Homo sapiens	25-28
27660387-1	2017	Aquaporin 0 (AQP0), the major intrinsic protein of the eye lens, plays a vital role in maintaining lens clarity by facilitating the transport of water across lens fiber cell membranes.	Water	145-150	major intrinsic protein of lens fiber	Homo sapiens	0-11
27660387-1	2017	Aquaporin 0 (AQP0), the major intrinsic protein of the eye lens, plays a vital role in maintaining lens clarity by facilitating the transport of water across lens fiber cell membranes.	Water	145-150	major intrinsic protein of lens fiber	Homo sapiens	13-17
27660387-2	2017	AQP0 reduces its osmotic water permeability constant (Pf) in response to increases in the external calcium concentration, an effect that is mediated by an interaction with the calcium-binding messenger protein, calmodulin (CaM), and phosphorylation of the CaM-binding site abolishes calcium sensitivity.	Water	25-30	major intrinsic protein of lens fiber	Homo sapiens	0-4
27530073-5	2017	Wastewater addition increased the reduction of both As(V) and Cr(VI) compared to the control (Milli-Q water) and the effect was more pronounced in the case of Cr(VI).	Water	5-10	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	52-57
28258571-1	2017	Several aquaporin (AQP )-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 -6 in the collecting duct; AQP7 in the proximal tubule; AQP8 in the proximal tubule and collecting duct; and AQP11 in the endoplasmic reticulum of proximal tubule cells.	Water	30-35	aquaporin 11	Mus musculus	260-265
28056940-8	2017	Approximately 22.58% (7/31) of case-patients and 2.56% (2/78) of controls drank water sold in small plastic bags (ORM-H = 8.90; 95%CI = 1.60-49.00); 54.54% (18/33) of case-patients and 19.23% (15/78) of controls consumed locally-made drinks (ORM-H = 4.60; 95%CI: 1.90-11.00).	Water	80-85	orosomucoid 1	Homo sapiens	114-117
28056940-8	2017	Approximately 22.58% (7/31) of case-patients and 2.56% (2/78) of controls drank water sold in small plastic bags (ORM-H = 8.90; 95%CI = 1.60-49.00); 54.54% (18/33) of case-patients and 19.23% (15/78) of controls consumed locally-made drinks (ORM-H = 4.60; 95%CI: 1.90-11.00).	Water	80-85	orosomucoid 1	Homo sapiens	242-245
28057077-7	2017	Ice ingestion with a long rest interval (-0.55 +- 0.07  C; both p &lt; 0.05) allowed for a greater drop in the core temperature than both ice ingestion with a short rest interval (-0.36 +- 0.16  C) and cold water ingestion (-0.11 +- 0.14  C).	Water	207-212	caspase 1	Homo sapiens	0-3
27989461-3	2017	Vasopressin levels begin to fall within minutes of water consumption, even prior to changes in blood osmolality.	Water	51-56	arginine vasopressin	Homo sapiens	0-11
28880970-8	2017	The isolation of BCRP is still not an easy task, because its insolubility in water and the presence of membrane rafts pose serious methodological and technical challenges during the purification.	Water	77-82	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	17-21
28971444-11	2017	Hepatic function was affected by both sugar products and water melon, which were positively correlated with total bilirubin and AST/SGOT respectively.	Water	57-62	solute carrier family 17 member 5	Homo sapiens	128-131
28054966-7	2017	Insulin AUC was higher for coffee and LFM versus OJ and water; (2) Glucose AUCs were not different among water and milks while insulin AUC was higher for milks versus water.	Water	56-61	insulin	Homo sapiens	0-7
28258579-5	2017	Cystic fibrosis transmembrane conductance regulator (CFTR ) was initially thought as a water channel but now not believed to transport water directly.	Water	135-140	CF transmembrane conductance regulator	Homo sapiens	0-51
28258579-5	2017	Cystic fibrosis transmembrane conductance regulator (CFTR ) was initially thought as a water channel but now not believed to transport water directly.	Water	135-140	CF transmembrane conductance regulator	Homo sapiens	53-57
28258579-5	2017	Cystic fibrosis transmembrane conductance regulator (CFTR ) was initially thought as a water channel but now not believed to transport water directly.	Water	87-92	CF transmembrane conductance regulator	Homo sapiens	0-51
28258579-5	2017	Cystic fibrosis transmembrane conductance regulator (CFTR ) was initially thought as a water channel but now not believed to transport water directly.	Water	87-92	CF transmembrane conductance regulator	Homo sapiens	53-57
28614812-5	2017	This "first" water channel was originally named CHIP28 and is now known as aquaporin 1.	Water	13-18	aquaporin 1 (Colton blood group)	Homo sapiens	48-54
28614812-5	2017	This "first" water channel was originally named CHIP28 and is now known as aquaporin 1.	Water	13-18	aquaporin 1 (Colton blood group)	Homo sapiens	75-86
29167584-1	2017	In this research we develop, test, and demonstrate the newest extension of the software HVAC-Cx (NIST and CSTB 2014), an automated commissioning tool for detecting common mechanical faults and control errors in chilled-water distribution systems (loops).	Water	219-224	cystatin B	Homo sapiens	106-110
27718428-2	2017	Over 90% As(V) and Se(VI) was removed by 2.5 g L-1 ZVI in Day-14 flowback water up to 96-h reaction, with the remaining concentration below the maximum contaminant level for As(V) and criterion continuous concentration for Se(VI) recommended by US EPA.	Water	74-79	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	9-14
28674250-11	2017	and ad libitum ingestion of the magnesium-rich mineral hard water (212 ppm as magnesium) partially, but significantly, attenuated the severity of colitis by decreasing the accumulation of P2X7R-immunopositive mast cells in the colon.	Water	60-65	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	188-193
28154309-8	2017	When the G-MRPs were placed in water, the porous matrix base was immediately dissolved, and each embedded MRP was individually released, thus inducing monodispersion and significantly improved dispersibility.	Water	31-36	ATP binding cassette subfamily C member 1	Homo sapiens	11-14
27718428-7	2017	The characterization of As(V)- and Se(VI)-loaded ZVI by X-ray diffraction and Raman analysis revealed that ZVI gradually converted to magnetite/maghemite corrosion products with lepidocrocite in flowback water over 30 days.	Water	204-209	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-29
27412400-2	2017	The equilibrium stability of an apoA-I molecule at the lipid interface (12.7 kcal/mol) predicted by a thermodynamic cycle for apolipoprotein folding-unfolding in water and at interface, largely exceeds apoA-I helix stability in HDL against chemical denaturation (3-5 kcal/mol).	Water	162-167	apolipoprotein A1	Homo sapiens	32-38
28117000-6	2017	We also discuss the significance of the inappropriate functioning of the vasopressin system for: the development of cardiovascular diseases; disturbances of the water-electrolyte balance; energy metabolism; inflammatory processes; pain; neurogenic stress; memory disorders; depression; anxiety; autism; and schizophrenia.	Water	161-166	arginine vasopressin	Homo sapiens	73-84
28714397-2	2017	The main function of AVP is the control of fluid homeostasis by inducing water conservation by the kidney, but it also stimulates arteriolar vasoconstriction and the release of adrenocorticotropic hormone (ACTH).	Water	73-78	arginine vasopressin	Homo sapiens	21-24
27412400-4	2017	The conformational transitions between apoA-I conformers in water and lipid phases correspond to Lumry-Eyring model OL   CL   MW, where OL and CL are open and closed structures of HDLbound apoA-I, and MW is the molten globule in water.	Water	229-234	apolipoprotein A1	Homo sapiens	39-45
27412400-4	2017	The conformational transitions between apoA-I conformers in water and lipid phases correspond to Lumry-Eyring model OL   CL   MW, where OL and CL are open and closed structures of HDLbound apoA-I, and MW is the molten globule in water.	Water	60-65	apolipoprotein A1	Homo sapiens	39-45
27436402-2	2017	The Maxwell"s stress generated from the electric field at the oil-water interface could deform, stretch, neck, pin, and disintegrate a droplet into many miniaturized daughter droplets, which eventually ushered a one-step method to form water-in-oil microemulsion employing microchannels.	Water	66-71	dynein light chain LC8-type 1	Homo sapiens	111-114
27436402-2	2017	The Maxwell"s stress generated from the electric field at the oil-water interface could deform, stretch, neck, pin, and disintegrate a droplet into many miniaturized daughter droplets, which eventually ushered a one-step method to form water-in-oil microemulsion employing microchannels.	Water	236-241	dynein light chain LC8-type 1	Homo sapiens	111-114
27974431-0	2017	BET 2: Ice water immersion, other vagal manoeuvres or adenosine for SVT in children.	Water	11-16	carboxylesterase 2	Homo sapiens	7-10
27974431-7	2017	This best evidence shows that ice water to the face appears to be a safe, quick, effective and non-invasive treatment for paediatric SVT.	Water	34-39	carboxylesterase 2	Homo sapiens	30-33
27622909-1	2017	INTRODUCTION: Since the discovery of aquaporin-1 (AQP1) as a water channel, more than 2,000 articles, reviews and chapters have been published.	Water	61-66	aquaporin 1 (Colton blood group)	Homo sapiens	37-48
27213514-7	2017	The water consumption rate was approximately 2.35 L min-1, while the total power consumed was 270 W. This study demonstrates that the ESWS could be a potentially effective and feasible tool in controlling PM emissions for commercial poultry facilities.	Water	4-9	CD59 molecule (CD59 blood group)	Homo sapiens	52-57
27844316-8	2017	Furthermore, the maximum concentrations in raw water of WTPs was kept at 82.1 ng L-1 for 2-MIB, 5.6 ng L-1 for geosmin, and 66.1 ng L-1 for beta-ionone.	Water	47-52	L1 cell adhesion molecule	Homo sapiens	81-84
27844316-8	2017	Furthermore, the maximum concentrations in raw water of WTPs was kept at 82.1 ng L-1 for 2-MIB, 5.6 ng L-1 for geosmin, and 66.1 ng L-1 for beta-ionone.	Water	47-52	L1 cell adhesion molecule	Homo sapiens	103-106
27844316-8	2017	Furthermore, the maximum concentrations in raw water of WTPs was kept at 82.1 ng L-1 for 2-MIB, 5.6 ng L-1 for geosmin, and 66.1 ng L-1 for beta-ionone.	Water	47-52	L1 cell adhesion molecule	Homo sapiens	103-106
27622909-1	2017	INTRODUCTION: Since the discovery of aquaporin-1 (AQP1) as a water channel, more than 2,000 articles, reviews and chapters have been published.	Water	61-66	aquaporin 1 (Colton blood group)	Homo sapiens	50-54
28656120-1	2017	BACKGROUND: Several studies have investigated copeptin as a prognostic marker of different acute diseases and as a diagnostic marker in disorders of water and salt homeostasis.	Water	149-154	arginine vasopressin	Homo sapiens	46-54
28432473-4	2017	Of current pharmacological interest are the selective and non-selective vasopressin receptor antagonists (VRAs), which inhibit vasoconstriction and cardiac remodeling mediated by the V1a receptors in smooth blood vessels, and water retention (increased urine osmolality and decreased water excretion) by increasing aquaporin-2 water channels mediated by the V2 receptors in the renal collecting tubules.	Water	284-289	arginine vasopressin	Homo sapiens	72-83
28133531-10	2017	CONCLUSION: Coumarin and ICE possess anti-inflammatory properties through inhibition of PGE2 and NO along with pro-inflammatory cytokines TNF-alpha, IL-6, IL-1beta production.	Water	25-28	tumor necrosis factor	Mus musculus	138-147
28133531-10	2017	CONCLUSION: Coumarin and ICE possess anti-inflammatory properties through inhibition of PGE2 and NO along with pro-inflammatory cytokines TNF-alpha, IL-6, IL-1beta production.	Water	25-28	interleukin 6	Mus musculus	149-153
28133531-10	2017	CONCLUSION: Coumarin and ICE possess anti-inflammatory properties through inhibition of PGE2 and NO along with pro-inflammatory cytokines TNF-alpha, IL-6, IL-1beta production.	Water	25-28	interleukin 1 beta	Mus musculus	155-163
28630783-7	2017	The limits of detection were 11.3, 29.2, and 46.0 nM for tap water, pond water, and iron supplement tablets, respectively.	Water	61-66	SEC14 like lipid binding 2	Homo sapiens	57-60
28028745-0	2017	Hexagonal ice in pure water and biological NMR samples.	Water	22-27	carboxylesterase 2	Homo sapiens	10-13
28028745-2	2017	We characterize its spectroscopic behavior in the temperature range from 100 to 273 K, and find that it behaves like pure water ice.	Water	122-127	carboxylesterase 2	Homo sapiens	128-131
27646203-10	2017	A homology model of the RyR2 pore-region showed that the I4855M mutant reside is located in the highly conserved "inner vestibule", a water-filled cavity.	Water	134-139	ryanodine receptor 2	Homo sapiens	24-28
28115125-1	2017	Photochemical production of carbonyl sulfide (COS), carbon disulfide (CS2) and dimethyl sulfide (DMS) was intensively studied in the water from the Aohai Lake of Beijing city.	Water	133-138	chorionic somatomammotropin hormone 2	Homo sapiens	70-73
28115125-2	2017	The lake water was found to be highly supersaturated with COS, CS2 and DMS, with their initial concentrations of 0.91+-0.073nmol/L, 0.55+-0.071nmol/L and 0.37+-0.062nmol/L, respectively.	Water	9-14	chorionic somatomammotropin hormone 2	Homo sapiens	63-66
28204526-6	2017	Additionally, a BCAT3 mutant was more sensitive to water-deficit stress than wild type plants.	Water	51-56	branched-chain aminotransferase 3	Arabidopsis thaliana	16-21
28115125-3	2017	The evident photochemical production of COS and CS2 in the lake water under irradiation of 365nm and 302nm indicated that photochemical production of them might be the reason for their supersaturation.	Water	64-69	chorionic somatomammotropin hormone 2	Homo sapiens	48-51
28115125-5	2017	The water cage effect was found to favor COS production but inhibit CS2 and DMS formation, indicating that COS photochemical production was mainly from direct degradation of the precursors and the formation of CS2 and DMS needed intermediates via combination of carbon-centered radicals and sulfur-centered radicals.	Water	4-9	chorionic somatomammotropin hormone 2	Homo sapiens	68-71
28115125-5	2017	The water cage effect was found to favor COS production but inhibit CS2 and DMS formation, indicating that COS photochemical production was mainly from direct degradation of the precursors and the formation of CS2 and DMS needed intermediates via combination of carbon-centered radicals and sulfur-centered radicals.	Water	4-9	chorionic somatomammotropin hormone 2	Homo sapiens	210-213
28115125-6	2017	The above assumptions were further confirmed by simulation experiments with addition of carbonyls and amino acids (cysteine and methionine), and the photochemical formation mechanisms for COS, CS2 and DMS in water were derived from the investigations.	Water	208-213	chorionic somatomammotropin hormone 2	Homo sapiens	193-196
27973744-5	2017	The lowest detectable concentration for lysozyme was 0.5 mug/mL in water and 5 mug/mL on a stainless steel food-handling surface.	Water	67-72	lysozyme	Homo sapiens	40-48
27619505-4	2017	A boiling water extract of ginseng inhibited SGLT1 in a concentration-dependent manner with an IC50 value of 0.85 mg/ml.	Water	10-15	solute carrier family 5 member 1	Homo sapiens	45-50
27770926-5	2017	The water resistance of the PHA-g-AA/TASP membranes was greater than that of the PHA/ASP membranes, and a cytocompatibility evaluation with human foreskin fibroblasts (FBs) indicated that both materials were nontoxic.	Water	4-9	lamin B receptor	Homo sapiens	28-36
26916835-6	2017	In comparison with SPI, GC-SPI showed enhanced water-binding capacity, could form aggregates with enlarged hydrodynamic radius (180.2 vs. 82.9 nm) and negative zeta-potential (-31.2 vs. -27.7 mV) in dispersion, but exhibited lower thermal stability (e.g. greater mass loss) upon heating at a temperature above 288  C. GC-SPI also had lower in vitro proteolytic digestibility than SPI due to the protein cross-linking.	Water	47-52	chromogranin A	Homo sapiens	27-30
26916835-6	2017	In comparison with SPI, GC-SPI showed enhanced water-binding capacity, could form aggregates with enlarged hydrodynamic radius (180.2 vs. 82.9 nm) and negative zeta-potential (-31.2 vs. -27.7 mV) in dispersion, but exhibited lower thermal stability (e.g. greater mass loss) upon heating at a temperature above 288  C. GC-SPI also had lower in vitro proteolytic digestibility than SPI due to the protein cross-linking.	Water	47-52	chromogranin A	Homo sapiens	27-30
26916835-6	2017	In comparison with SPI, GC-SPI showed enhanced water-binding capacity, could form aggregates with enlarged hydrodynamic radius (180.2 vs. 82.9 nm) and negative zeta-potential (-31.2 vs. -27.7 mV) in dispersion, but exhibited lower thermal stability (e.g. greater mass loss) upon heating at a temperature above 288  C. GC-SPI also had lower in vitro proteolytic digestibility than SPI due to the protein cross-linking.	Water	47-52	chromogranin A	Homo sapiens	27-30
27770926-5	2017	The water resistance of the PHA-g-AA/TASP membranes was greater than that of the PHA/ASP membranes, and a cytocompatibility evaluation with human foreskin fibroblasts (FBs) indicated that both materials were nontoxic.	Water	4-9	lamin B receptor	Homo sapiens	28-31
28228348-9	2017	Moreover, an increase in liver lipid accumulation of rats treated with gaseous drinks is shown opposed to control rats treated with degassed beverage or tap water.	Water	157-162	nuclear RNA export factor 1	Rattus norvegicus	153-156
28735404-5	2017	In this chapter, we describe the development and validation of a PGC-based liquid chromatography tandem mass spectrometry (LC-MSn) method suitable for the target analysis of water-soluble carbohydrates, such as raffinose family oligosaccharides (RFOs).	Water	174-179	moesin	Homo sapiens	126-129
27918546-2	2017	We show that the urea transporter (UT-B) can be used as a gene reporter, where reporter expression is detected using 1H MRI measurements of UT-B-mediated increases in plasma membrane water exchange.	Water	183-188	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	35-39
27918546-2	2017	We show that the urea transporter (UT-B) can be used as a gene reporter, where reporter expression is detected using 1H MRI measurements of UT-B-mediated increases in plasma membrane water exchange.	Water	183-188	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	140-144
27918546-3	2017	HEK cells transfected with the reporter showed an increased apparent water exchange rate (AXR), which increased in line with UT-B expression.	Water	69-74	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	125-129
27908549-4	2017	RESULTS: The water extracts (dose-dependently for noni leaves) increased bone regeneration biomarker (runt-related transcription factor 2, bone morphogenetic protein 2, osteoprotegerin, estrogen receptor 1 [ESR1], collagen type I alpha 1A) expressions and reduced the inflammatory biomarkers (interleukin-6, tumor necrosis factor-alpha, nuclear factor [NF]-kappaB, and receptor activator of NF-kappaB ligand) mRNA expressions/levels in the rats.	Water	13-18	RUNX family transcription factor 2	Rattus norvegicus	102-137
27908549-4	2017	RESULTS: The water extracts (dose-dependently for noni leaves) increased bone regeneration biomarker (runt-related transcription factor 2, bone morphogenetic protein 2, osteoprotegerin, estrogen receptor 1 [ESR1], collagen type I alpha 1A) expressions and reduced the inflammatory biomarkers (interleukin-6, tumor necrosis factor-alpha, nuclear factor [NF]-kappaB, and receptor activator of NF-kappaB ligand) mRNA expressions/levels in the rats.	Water	13-18	interleukin 6	Rattus norvegicus	293-306
28145211-6	2017	In this group of patients, liberal doses of insulin, fluids and bicarbonate may lead to a decrease in the effective serum osmolarity which can lead to water shifts in the cerebrum.	Water	151-156	insulin	Homo sapiens	44-51
28603108-3	2017	The separation was carried out on C18 column by using mobile phase as mixture of water and methanol (45:55%v/v).	Water	81-86	Bardet-Biedl syndrome 9	Homo sapiens	34-37
28741466-2	2017	Most of our knowledge on GroEL function is derived from studies with denatured water-soluble proteins or short peptide mimetics.	Water	79-84	GroEL	Escherichia coli	25-30
28740739-0	2017	A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1.	Water	11-16	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	105-110
28740739-4	2017	We hypothesized that the water extraction of frankincense and myrrh (WFM) exerted its analgesia effect by modulating the neuronal function of TRPV1.	Water	25-30	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	142-147
28684123-10	2017	On the other hand, higher aspirin doses have been reported to exert a negative impact on blood pressure due to inhibition of cyclooxygenase-2 activity, which reduces renal blood flow, glomerular filtration rate and sodium and water excretion.	Water	226-231	prostaglandin-endoperoxide synthase 2	Homo sapiens	125-141
28190398-3	2017	As facilitated by our discovery in 2005 that "completely insoluble" proteins could be solubilized in unsalted water, we have deciphered that disease- and aging-associated factors act to eliminate the native folds of human VAPB-MSP and SOD1, as well as E. coli S1 ribosomal protein, consequently unlocking amphiphilic/hydrophobic regions universally existing in proteins.	Water	110-115	VAMP associated protein B and C	Homo sapiens	222-226
28219320-3	2017	Although, World Health Organization (WHO) has set the limit of Cd in drinking water is 0.005 mg L-1, the industrial activities release much higher concentrations of metal ions to the water stream than the prescribed limits, which leads to the increasing health hazards and environmental pollution.	Water	78-83	immunoglobulin kappa variable 1-16	Homo sapiens	96-99
28100855-10	2016	Formed hydrogen peroxide is decomposed into water and oxygen by catalase or glutathione peroxidase.	Water	44-49	catalase	Homo sapiens	64-72
27768907-8	2017	The water-soluble components (SO42-, NO3-, NH4+ and WSOC) showed a clear diurnal variation due to the specific meteorological conditions of Mount Tai.	Water	4-9	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
27908452-3	2017	In batch ozonation experiments, the formation of NO3- and NH4+ was investigated for natural organic matter standards, surface water, and wastewater effluent samples.	Water	126-131	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
27908452-4	2017	A good correlation was found between NO3- formation and the O3 exposure (R2 &gt; 0.82) during ozonation of both model DON solutions and real water samples.	Water	141-146	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
27923288-3	2017	The present study found that TLR4 played a protective role in a mouse model of water immersion (23  C) restraint stress.	Water	79-84	toll-like receptor 4	Mus musculus	29-33
28665380-10	2017	The beneficial therapeutic action of acupuncture and drinking mineral water is underlain by their impact on the mechanisms of resistance to insulin that manifests itself as a decrease of the fasting secretion of this hormone and optimization of carbohydrate and lipid metabolism.	Water	70-75	insulin	Homo sapiens	140-147
28665380-11	2017	The therapeutic effect of acupuncture and drinking mineral water is realized through the induction of the stress-initiating reactions which activate the processes of adaptation, with reflexotherapy largely acting on the cardiovascular system and drinking mineral water on the system responsible for insulin regulation of the metabolic processes.	Water	59-64	insulin	Homo sapiens	299-306
28665380-11	2017	The therapeutic effect of acupuncture and drinking mineral water is realized through the induction of the stress-initiating reactions which activate the processes of adaptation, with reflexotherapy largely acting on the cardiovascular system and drinking mineral water on the system responsible for insulin regulation of the metabolic processes.	Water	263-268	insulin	Homo sapiens	299-306
28948731-3	2017	The effect of water extraction on activity of alkaline phosphatase (ALP) in osteoblast was referred as the evaluation index for investigating four factors: water consumption (A), heating time (B), soaking time (C), and number of decocting (D), analyzing the optimum extraction conditions, and verifying the effectiveness of this process.	Water	14-19	alkaline phosphatase, placental	Homo sapiens	46-66
28948731-3	2017	The effect of water extraction on activity of alkaline phosphatase (ALP) in osteoblast was referred as the evaluation index for investigating four factors: water consumption (A), heating time (B), soaking time (C), and number of decocting (D), analyzing the optimum extraction conditions, and verifying the effectiveness of this process.	Water	14-19	alkaline phosphatase, placental	Homo sapiens	68-71
28948731-3	2017	The effect of water extraction on activity of alkaline phosphatase (ALP) in osteoblast was referred as the evaluation index for investigating four factors: water consumption (A), heating time (B), soaking time (C), and number of decocting (D), analyzing the optimum extraction conditions, and verifying the effectiveness of this process.	Water	156-161	alkaline phosphatase, placental	Homo sapiens	46-66
28036023-4	2016	AQP1 and AQP4, the two primary aquaporin molecules of the central nervous system, regulate brain water and CSF movement and contribute to cytotoxic and vasogenic edema, where they control the size of the intracellular and extracellular fluid volumes, respectively.	Water	97-102	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
32263790-4	2016	The results confirmed the successful synthesis of PEG-EP3, which showed high water dispersibility with a size distribution of 249 +- 1 nm, intense yellow-green fluorescence in aqueous solution with a fluorescence quantum yield of 35%, and a low critical micelle concentration (CMC) of 0.039 mg mL-1.	Water	77-82	prostaglandin E receptor 3	Homo sapiens	54-57
27689385-0	2016	High-Efficiency Fog Collector: Water Unidirectional Transport on Heterogeneous Rough Conical Wires.	Water	31-36	zinc finger protein, FOG family member 1	Homo sapiens	16-19
28144360-6	2016	The physical stability of nanoTiO2 dispersions is diminished in the presence of the salts found in tap water (and occurring also in surface waters and ground water) and they are precipitated immediately.	Water	103-108	USO1 vesicle transport factor	Homo sapiens	99-102
28144360-6	2016	The physical stability of nanoTiO2 dispersions is diminished in the presence of the salts found in tap water (and occurring also in surface waters and ground water) and they are precipitated immediately.	Water	140-145	USO1 vesicle transport factor	Homo sapiens	99-102
28144360-9	2016	The photocatalytic degradation of methylene blue and ibuprofen as model organic pollutants in various media (distilled water, NaCl solution and tap water) has been studied using nanoTiO2 as catalyst stabilized by CMBCD-P.	Water	148-153	USO1 vesicle transport factor	Homo sapiens	144-147
27373564-2	2016	In eye lens tissue, circulation of water, ions and metabolites is ensured by a microcirculation system in which aquaporin-0 (AQP0) plays a central role.	Water	35-40	major intrinsic protein of lens fiber	Homo sapiens	112-123
27940912-2	2016	Accumulated evidence suggests that the reaction path of PKMT-catalyzed methylation consists of the formation of a cofactor(cosubstrate)-PKMT-substrate complex, lysine deprotonation through dynamic water channels, and a nucleophilic substitution (SN2) transition state for transmethylation.	Water	197-202	solute carrier family 38 member 5	Homo sapiens	246-249
27984871-1	2016	A nitrate ion (NO3-) with its trigonal planar geometry and charges distributed among nitrogen and oxygen atoms can couple to the extensive hydrogen bond network of water to give rise to unique dynamical characteristics.	Water	164-169	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
27924325-4	2016	LB-1 exhibits good thermal and water stability.	Water	31-36	cytoskeleton associated protein 2	Homo sapiens	0-4
28010091-5	2016	In order to provide a molecular origin of this structural transition, we explore the conformational free energy landscape of Cyt C as a function of radius of gyration (Rg) at different compositions of water-ethanol binary mixture using MD simulations.	Water	201-206	cytochrome c, somatic	Homo sapiens	125-130
28010091-6	2016	Cyt C exhibits a minimum at Rg ~ 13 A in bulk water (0% alcohol).	Water	46-51	cytochrome c, somatic	Homo sapiens	0-5
27373564-2	2016	In eye lens tissue, circulation of water, ions and metabolites is ensured by a microcirculation system in which aquaporin-0 (AQP0) plays a central role.	Water	35-40	major intrinsic protein of lens fiber	Homo sapiens	125-129
27373564-3	2016	AQP0 allows water to flow beyond the diffusion limit through lens membranes.	Water	12-17	major intrinsic protein of lens fiber	Homo sapiens	0-4
27373564-9	2016	The results highlight a well-defined region that surrounds AQP0 tetramers and where water exhibits a higher affinity for the protein.	Water	84-89	major intrinsic protein of lens fiber	Homo sapiens	59-63
27974818-0	2016	Cadmium(II) inhibition of human uracil-DNA glycosylase by catalytic water supplantation.	Water	68-73	uracil DNA glycosylase	Homo sapiens	32-54
27585279-0	2016	Pilot-plant evaluation of TiO2 and TiO2-based hybrid photocatalysts for solar treatment of polluted water.	Water	100-105	tiptop	Drosophila melanogaster	26-29
27692472-2	2016	MUM-Fate is a Level III steady-state fugacity model consisting of seven bulk media compartments (lower and upper air, surface water, sediment, soil, vegetation, and an organic film that coats impervious surfaces).	Water	126-131	latexin	Homo sapiens	0-3
27984880-9	2016	Finally, we compare the PEL properties explored during the LDA-HDA transformations in ST2 water with those reported previously for SPC/E water, for which the LDA-HDA transformations are rather smooth.	Water	137-142	proline rich protein gene cluster	Homo sapiens	131-134
33465887-0	2016	Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces.	Water	77-82	fibrinogen beta chain	Homo sapiens	27-37
28799362-13	2016	A maximum in the compressibility was found for the TIP4P/ICE model in supercooled water.	Water	82-87	carboxylesterase 2	Homo sapiens	57-60
27589821-2	2016	Water-soluble inorganic ions (WSIIs) including Na+, NH4+, K+, Mg2+, Ca2+, Cl-, NO3- and SO42-, organic carbon (OC) and elemental carbon (EC) and water-soluble organic carbon (WSOC) were analysed.	Water	0-5	NBL1, DAN family BMP antagonist	Homo sapiens	79-82
27866853-4	2016	Using the serotonin receptor (5-HT3R) structure as an example, we demonstrate the use of molecular dynamics to aid the functional annotation of channel structures via simulation of the behavior of water within the pore.	Water	197-202	5-hydroxytryptamine receptor 3A	Homo sapiens	30-36
27919235-7	2016	RESULTS: The TRF index which consists of drinking water sources, toilet facility types, and population density appeared to be statistically significant to explain variation in the disease burden data.	Water	50-55	telomeric repeat binding factor 1	Homo sapiens	13-16
29259448-3	2017	In contrast, water, glycerol, and ethylene glycerol move rapidly through morulae and blastocysts, principally by facilitated diffusion via aquaporin 3, in the mouse and bovine; whereas, in the pig, the permeability to water and these cryoprotectants increases not at the morula stage but at the blastocyst stage and further increases at the expanded blastocyst stage.	Water	13-18	aquaporin 3	Mus musculus	139-150
27422165-4	2016	AIM OF THE STUDY: This study aims to investigate the regulatory effect of the water extract of SP (WESP) and RA on efflux transports (ETs), including P-glycoprotein (p-gp), multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in HepG2 cell line.	Water	78-83	ATP binding cassette subfamily B member 1	Homo sapiens	150-164
27422165-4	2016	AIM OF THE STUDY: This study aims to investigate the regulatory effect of the water extract of SP (WESP) and RA on efflux transports (ETs), including P-glycoprotein (p-gp), multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in HepG2 cell line.	Water	78-83	ATP binding cassette subfamily B member 1	Homo sapiens	166-170
27422165-4	2016	AIM OF THE STUDY: This study aims to investigate the regulatory effect of the water extract of SP (WESP) and RA on efflux transports (ETs), including P-glycoprotein (p-gp), multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in HepG2 cell line.	Water	78-83	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	227-259
27422165-4	2016	AIM OF THE STUDY: This study aims to investigate the regulatory effect of the water extract of SP (WESP) and RA on efflux transports (ETs), including P-glycoprotein (p-gp), multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in HepG2 cell line.	Water	78-83	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	261-265
28076507-7	2016	RESULTS:: Clinical scores, TNF-alpha, IL-1beta, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments.	Water	129-134	tumor necrosis factor	Rattus norvegicus	27-36
28076507-7	2016	RESULTS:: Clinical scores, TNF-alpha, IL-1beta, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments.	Water	129-134	interleukin 1 beta	Rattus norvegicus	38-46
27784697-2	2016	A key mechanism involved in this process, the arginine vasopressin-mediated phosphorylation and apical membrane insertion of aquaporin 2 in the collecting duct, has been extensively studied; however, with the increased availability of conditional knockout animals, several novel collecting duct proteins have recently been implicated in water homeostasis.	Water	337-342	arginine vasopressin	Homo sapiens	55-66
27760771-2	2016	Water reabsorption in the collecting duct principal cells is controlled by vasopressin, a peptide hormone that induces the osmotic water transport across the collecting duct epithelia through regulation of water channel proteins aquaporin-2 (AQP2) and aquaporin-3 (AQP3).	Water	0-5	arginine vasopressin	Homo sapiens	75-86
27760771-2	2016	Water reabsorption in the collecting duct principal cells is controlled by vasopressin, a peptide hormone that induces the osmotic water transport across the collecting duct epithelia through regulation of water channel proteins aquaporin-2 (AQP2) and aquaporin-3 (AQP3).	Water	131-136	arginine vasopressin	Homo sapiens	75-86
27663039-0	2016	Low-Osmolar Diet and Adjusted Water Intake for Vasopressin Reduction in Autosomal Dominant Polycystic Kidney Disease: A Pilot Randomized Controlled Trial.	Water	30-35	arginine vasopressin	Homo sapiens	47-58
27663039-14	2016	Furthermore, this intervention led to a reduction in water required for vasopressin reduction.	Water	53-58	arginine vasopressin	Homo sapiens	72-83
27565657-3	2016	Although in MS/MS, their CID spectra show similar trends, e.g., release of water and ethanol, the [(LAA(*D/*E)+H)-C2H5OH]+ product ions dissociate via distinct pathways in sequential MS3 experiments.	Water	75-80	MS3	Homo sapiens	183-186
26429198-7	2016	These findings provide direct evidence for AQP4 and AQP5 expression in the large intestine, suggesting that different AQPs collaborate functionally and distinctively in water handling during intestinal development, especially during the first period after delivery.	Water	169-174	aquaporin 5	Bos taurus	52-56
27387738-1	2016	BACKGROUND: We present a quick and easy method to perform quantitatively accurate PET scans of typical water-filled PET plastic shell phantoms on the Siemens Biograph mMR PET/MR system.	Water	103-108	ATPase, class II, type 9B	Mus musculus	167-170
27752730-3	2016	It also focuses on bentonite as a natural adsorbent and on the adsorption process of Pb(II) ions on the mixture of bentonite and bottom sediment from the water reservoir in Kolinany (SR).	Water	154-159	submaxillary gland androgen regulated protein 3B	Homo sapiens	85-91
27591568-10	2016	COP2 produces a greater effect than COP1 in decreasing the water outflow through DPPC LUVs in the same concentration range.	Water	59-64	COP1 E3 ubiquitin ligase	Homo sapiens	36-40
27649310-6	2016	In fouling experiments using tap water containing 50 mg L-1 alginate, a simple backwash could remove the fouling on Alg L immobilized membrane, but not that on the control membrane.	Water	33-38	immunoglobulin kappa variable 1-16	Homo sapiens	56-59
27593225-1	2016	Vasopressin (AVP) regulates the body salt-water balance.	Water	42-47	arginine vasopressin	Rattus norvegicus	0-11
27593225-1	2016	Vasopressin (AVP) regulates the body salt-water balance.	Water	42-47	arginine vasopressin	Rattus norvegicus	13-16
27614262-4	2016	However, degradation rate in soil-water based slurry system was slow as it took 10 days to degrade 82% of added chlorpyrifos (50mg/kg) by a potential mixed culture CS2 comprised of isolates F-3 and CH-y.	Water	34-39	chorionic somatomammotropin hormone 2	Homo sapiens	164-167
27387738-1	2016	BACKGROUND: We present a quick and easy method to perform quantitatively accurate PET scans of typical water-filled PET plastic shell phantoms on the Siemens Biograph mMR PET/MR system.	Water	103-108	ATPase, class II, type 9B	Mus musculus	168-170
27619373-2	2016	Total heavy metal concentrations ranged from 34.88 to 4201.23 mug L-1 in water (as the sum of the water dissolved phase and suspended particulate matter) and from 42.81 to 1686.84 mg kg-1 in sediment samples.	Water	73-78	immunoglobulin kappa variable 1-16	Homo sapiens	66-69
26303504-5	2016	The water-soluble and insoluble fractions of PM2.5 suspension were both shown to induce IL-8 expression.	Water	4-9	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
27699485-0	2016	Passive and post-exercise cold-water immersion augments PGC-1alpha and VEGF expression in human skeletal muscle.	Water	31-36	PPARG coactivator 1 alpha	Homo sapiens	56-66
27699485-0	2016	Passive and post-exercise cold-water immersion augments PGC-1alpha and VEGF expression in human skeletal muscle.	Water	31-36	vascular endothelial growth factor A	Homo sapiens	71-75
27699485-1	2016	PURPOSE: We tested the hypothesis that both post-exercise and passive cold water immersion (CWI) increases PGC-1alpha and VEGF mRNA expression in human skeletal muscle.	Water	75-80	PPARG coactivator 1 alpha	Homo sapiens	107-117
27699485-1	2016	PURPOSE: We tested the hypothesis that both post-exercise and passive cold water immersion (CWI) increases PGC-1alpha and VEGF mRNA expression in human skeletal muscle.	Water	75-80	vascular endothelial growth factor A	Homo sapiens	122-126
27966071-1	2016	By combining the local structure index with potential energy minimisations we study the local environment of the water molecules for a couple of water models, TIP5P-Ew and SPC/E, in order to characterise low- and high-density "species".	Water	113-118	proline rich protein gene cluster	Homo sapiens	172-175
27612790-1	2016	A water resistant surface was first obtained by immobilizing hydrophobic copolymers, poly (styrene-co-glycidyl methacrylate) (PSG), with functional groups on soy protein isolate (SPI) films.	Water	2-7	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	126-129
27405269-7	2016	The EPS forms a complex with Hg2+ in water with small activation energy (&lt;=2 kJ mol-1), achieving about 30 mg Hg2+ adsorption per gram dry weight of EPS.	Water	37-42	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	83-88
27789808-8	2016	In addition, the elevation in AVP in the LD group was inversely correlated with an increase in free water clearance but not serum osmolality and was related to poor outcome.	Water	100-105	arginine vasopressin	Homo sapiens	30-33
27959974-6	2016	The average 95% prediction interval for estimating Psg" using accelerometer level was +-2.53 cm H2O, ranging from +-1.70 to +-3.74 cm H2O across participants.	Water	96-99	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	51-54
27959974-6	2016	The average 95% prediction interval for estimating Psg" using accelerometer level was +-2.53 cm H2O, ranging from +-1.70 to +-3.74 cm H2O across participants.	Water	134-137	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	51-54
27612790-1	2016	A water resistant surface was first obtained by immobilizing hydrophobic copolymers, poly (styrene-co-glycidyl methacrylate) (PSG), with functional groups on soy protein isolate (SPI) films.	Water	2-7	chromogranin A	Homo sapiens	179-182
27779666-1	2016	The aim of the present study was to determine the effects of the insulin-like growth factor 1 (IGF-1)/phosphatase and tensin homologue deleted on chromosome 10 (PTEN)/Akt/forkhead box (FoxO) signaling pathway on male reproduction in rats subjected to water immersion and restraint stress (WRS).	Water	251-256	AKT serine/threonine kinase 1	Rattus norvegicus	167-170
27494660-10	2016	For atrazine, concentrations were found in the range from 2.0 to 6.0ngL-1 in drinking water and at concentrations of up to 15ngL-1 in source water.	Water	141-146	leucine rich repeat containing 4C	Homo sapiens	125-130
26911569-7	2016	Its sensitivity was found to be satisfactory for the forthcoming sensor application in the water-sample analysis; the linear range was 0.01-1.5 mM and limit of detection 10 muM.	Water	91-96	latexin	Homo sapiens	173-176
27907132-5	2016	In the second step the protein is applied at very high loadings on a cation exchange resin and eluted in a mixture of water and ethanol to obtain a concentrated insulin precursor, suitable for use directly in the transpeptidation reaction.	Water	118-123	insulin	Homo sapiens	161-168
28008190-1	2016	Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water.	Water	224-229	arginine vasopressin	Homo sapiens	125-128
27580719-6	2016	We report the first high-resolution structures of TDG in an enzyme-substrate complex, for G U bound to TDG82-308 (1.54 A) and TDG111-308 (1.71 A), revealing new enzyme-substrate contacts, direct and water-mediated.	Water	199-204	thymine DNA glycosylase	Homo sapiens	50-53
27902456-5	2016	Finally, CR in ApoE-/- mice caused neuroprotection as indicated by a higher synaptic plasticity shown by immunohistochemical analysis with increased numbers of PSD95-positive neurons and a better cognitive performance as analyzed with Morris water maze test.	Water	242-247	apolipoprotein E	Mus musculus	15-19
27750124-4	2016	The process produced a mineral water meeting 115 of 115 Florida drinking water standards that, after 10 months of recycle operation with ~14% rainwater make-up, had a total dissolved solids of ~500 mg/L, pH 7.8 +- 0.4, turbidity 0.12 +- 0.06 NTU, and NO3-N concentration 3.0 +- 1.0 mg/L.	Water	31-36	NBL1, DAN family BMP antagonist	Homo sapiens	251-254
27771605-0	2016	Biodegradability of DBP precursors after drinking water ozonation.	Water	50-55	D-box binding PAR bZIP transcription factor	Homo sapiens	20-23
27933924-2	2016	These results together with online mass spectrometry experiments using 17O and 18O isotopically labeled compounds prove that this compound is a key intermediate of the water oxidation reaction catalyzed by the peroxido-bridged complex {[CoIII(trpy)]2(mu-bpp)(mu-OO)}3+ (13+).	Water	168-173	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	237-242
27904802-7	2016	Findings revealed highly eutrophic water conditions in JB compared to the outer Thousand Islands, with 44% higher DIN load (7.65 muM/L), 67% higher NTU (1.49 NTU) and 47% higher sedimentation rate (30.4 g m-2 d-1).	Water	35-40	latexin	Homo sapiens	129-132
27932763-6	2016	Compared with the model group, the first black stool time in the model +VIP group was shortened, the fecal water content increased significantly (both P&lt;0.05); the mucosal epithelium integrity improved, the number of goblet cells increased; the content of AQP3 and VIP in colon tissues was increased, and the cAMP, PKA, and AQP3 mRNA levels were elevated (all P&lt;0.05).	Water	107-112	vasoactive intestinal peptide	Rattus norvegicus	72-75
27685831-4	2016	The obtained water-dispersible H-MON spheres bearing sp- and sp2 -hybridized carbon atoms possess a highly conjugated electronic structure and show low reduction potential; thus, they can serve as a reducing agent and stabilizer for electroless deposition of highly dispersed Pd clusters to form a Pd/H-MON spherical hollow nanocomposite.	Water	13-18	Sp2 transcription factor	Homo sapiens	61-64
27897987-3	2016	We propose an atmospheric correction method based on a look up table coupled by the atmosphere radiative transfer model (6S) and the water semi-empirical radiative transfer (SERT) model for inversion of water-leaving reflectance from GF-1 top-of-atmosphere radiance, and then retrieving SPM concentration from water-leaving radiance reflectance of the Yangtze Estuary and its adjacent sea.	Water	133-138	GATA binding protein 1	Homo sapiens	234-238
27897987-3	2016	We propose an atmospheric correction method based on a look up table coupled by the atmosphere radiative transfer model (6S) and the water semi-empirical radiative transfer (SERT) model for inversion of water-leaving reflectance from GF-1 top-of-atmosphere radiance, and then retrieving SPM concentration from water-leaving radiance reflectance of the Yangtze Estuary and its adjacent sea.	Water	203-208	GATA binding protein 1	Homo sapiens	234-238
27897987-3	2016	We propose an atmospheric correction method based on a look up table coupled by the atmosphere radiative transfer model (6S) and the water semi-empirical radiative transfer (SERT) model for inversion of water-leaving reflectance from GF-1 top-of-atmosphere radiance, and then retrieving SPM concentration from water-leaving radiance reflectance of the Yangtze Estuary and its adjacent sea.	Water	203-208	GATA binding protein 1	Homo sapiens	234-238
27620335-3	2016	Lysozyme was dissolved in solutions with various ratios of ethanol and water, and subsequently spray-dried.	Water	71-76	lysozyme	Homo sapiens	0-8
27620335-5	2016	The aerosol performance of the spray-dried lysozyme from ethanol-water solution was improved compared to that from pure water.	Water	65-70	lysozyme	Homo sapiens	43-51
27620335-5	2016	The aerosol performance of the spray-dried lysozyme from ethanol-water solution was improved compared to that from pure water.	Water	120-125	lysozyme	Homo sapiens	43-51
27620335-6	2016	The conformation of lysozyme in the ethanol-water solution and spray dried powder was altered, but the native structure of lysozyme was restored upon reconstitution in water after the spray drying process.	Water	44-49	lysozyme	Homo sapiens	20-28
27620335-6	2016	The conformation of lysozyme in the ethanol-water solution and spray dried powder was altered, but the native structure of lysozyme was restored upon reconstitution in water after the spray drying process.	Water	168-173	lysozyme	Homo sapiens	123-131
27568834-0	2016	Imidafenacin exerts the antidiuretic effect by enhancing vasopressin-related responses in orally water-loaded rats.	Water	97-102	arginine vasopressin	Rattus norvegicus	57-68
27203463-8	2016	Furthermore, by employing C-reactive protein as a model, we successfully demonstrated that the new water-swellable polymer-based ICA sensor can be utilized to detect biologically relevant analytes in human serum.	Water	99-104	C-reactive protein	Homo sapiens	26-44
27568834-2	2016	The cholinergic and vasopressin systems are known to interact, for example, in the suppression of vasopressin-induced water reabsorption through muscarinic stimulation in the renal collecting duct.	Water	118-123	arginine vasopressin	Rattus norvegicus	98-109
27568834-2	2016	The cholinergic and vasopressin systems are known to interact, for example, in the suppression of vasopressin-induced water reabsorption through muscarinic stimulation in the renal collecting duct.	Water	118-123	arginine vasopressin	Rattus norvegicus	20-31
27472074-0	2016	Non-equilibrium passive sampling of hydrophobic organic contaminants in sediment pore-water: PCB exchange kinetics.	Water	86-91	pyruvate carboxylase	Homo sapiens	93-96
27798160-0	2016	Water-in-Oil-Only Adjuvants Selectively Promote T Follicular Helper Cell Polarization through a Type I IFN and IL-6-Dependent Pathway.	Water	0-5	interleukin 6	Mus musculus	111-115
27714012-7	2016	Moreover we were able to show that water-mediated hydrogen bonds are present between ERG and DNA in our simulations and that those interactions have the potential to achieve sequence recognition outside the GGAA core DNA-sequence.	Water	35-40	ETS transcription factor ERG	Homo sapiens	85-88
33440522-5	2016	In this strategy nanoimprint lithography was used to create water-stable films of bovine serum albumin (BSA) that are nonadhesive toward bacteria because of their negative/zwitterionic surface potential.	Water	60-65	albumin	Homo sapiens	89-102
27619495-7	2016	Post-fire water was amenable to conventional treatment at a 10 mg L-1 higher average alum dose than reference samples.	Water	10-15	immunoglobulin kappa variable 1-16	Homo sapiens	66-69
27694043-8	2016	Scanning environmental microscope analysis revealed that sludge flocs conditioned by Alb and Alc (especially PAC2.5 and Al13) exhibited obvious botryoidal structure, this is because sludge flocs formed by Alb and Alc were more compact and floc strength is high, it was easy generated plentiful tiny channels for water release.	Water	312-317	albumin	Homo sapiens	85-88
27694043-8	2016	Scanning environmental microscope analysis revealed that sludge flocs conditioned by Alb and Alc (especially PAC2.5 and Al13) exhibited obvious botryoidal structure, this is because sludge flocs formed by Alb and Alc were more compact and floc strength is high, it was easy generated plentiful tiny channels for water release.	Water	312-317	albumin	Homo sapiens	205-208
27696875-1	2016	We report the synthesis, spectroscopy, and the DNA binding properties of a biocompatible, water-soluble, polycationic two-photon absorbing anthracenyl derivative (Ant-PIm) specifically designed for biorelated applications.	Water	90-95	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	167-170
27673372-4	2016	We apply this method to bulk liquid water at atmospheric pressure and different temperatures using the SPC/E water force field.	Water	36-41	proline rich protein gene cluster	Homo sapiens	103-106
27793394-4	2016	By combining C18-MPSBSE with HPLC-UV, a method was proposed for the direct determination of two common non-steroidal anti-inflammatory drugs, Ketoprofen (KEP) and Naproxen (NAP) in complex water samples.	Water	189-194	Bardet-Biedl syndrome 9	Homo sapiens	13-16
27673372-4	2016	We apply this method to bulk liquid water at atmospheric pressure and different temperatures using the SPC/E water force field.	Water	109-114	proline rich protein gene cluster	Homo sapiens	103-106
27740943-11	2016	Water-equivalent plastics such as, Plastic Water, RMI-457, Gammex 457-CTG, WT1 and Virtual Water, gave similar results where maximum corrections were of the order of 2%.	Water	0-5	WT1 transcription factor	Homo sapiens	75-78
27616427-5	2016	The cup-shaped structure of 2 is able to include water, hydrogen cyanide, and acetylene, forming H2 O@2, HCN@2, and C2 H2 @2, respectively.	Water	49-54	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	105-110
27766866-1	2016	We obtained resonant two-photon ionization circular dichroism (R2PICD) spectra of jet-cooled phenylalanine (Phe) and its hydrated clusters (Phe(H2O)n, n = 1-2) near the origin band of the S0-S1 transition.	Water	144-147	F-box and leucine rich repeat protein 15	Homo sapiens	82-85
27825231-4	2016	The method is then employed to simulate an Abeta fibril model in the presence of bubbles, and the results show that the bubble expansion and contraction exert water pressure on the fibril.	Water	159-164	amyloid beta precursor protein	Homo sapiens	43-48
27763765-10	2016	Moreover, MAF-5(Co) can easily be regenerated by simple evacuation and reused, and thus it was found to be a potential adsorbent for the removal of spilled oil from water.	Water	165-170	MAF bZIP transcription factor	Homo sapiens	10-13
27318738-10	2016	Results showed that Ag/lyz-Mt nanomaterial could be a promising bactericide for water disinfection.	Water	80-85	lysozyme	Homo sapiens	23-26
27774535-1	2016	Partial reductive hydrolysis of a penta-CoII/III cluster [Co(H2O)2(CoIIIW9O34)(PW9O34)]12- (1) leads to the formation of [Co2{Co3(H2O)(Co(OH)2W7O26)(PW9O34)}2]22- (2).	Water	61-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
27726386-8	2016	Employing this insight, we developed a novel Hamiltonian Replica Exchange-based method "SWISH" (Sampling Water Interfaces through Scaled Hamiltonians), which combined with probes resulted in a promising general approach for cryptic site discovery.	Water	105-110	cripto, FRL-1, cryptic family 1	Homo sapiens	224-231
27665146-9	2016	RESULTS: Water significantly increased the modulus of NG1 and NG2 dispersed in solvent, while significantly decreased the stiffness of NG3.	Water	9-14	chondroitin sulfate proteoglycan 4	Homo sapiens	62-65
27682194-2	2016	TFE5 and TFE6 models of TFE developed in previous work from this laboratory were used with the TIP5PE model of water.	Water	111-116	bromodomain adjacent to zinc finger domain 2A	Homo sapiens	95-99
27723330-6	2016	The ns-TR3 and density functional theory (DFT) computational results were compared, and this indicates the binol moiety and water molecules both have important roles in the characteristics and structure of the key reactive BQM intermediate produced from BQMP-b.	Water	124-129	nuclear receptor subfamily 4 group A member 1	Homo sapiens	7-10
27990284-7	2016	SLA was formulated in an oil-in-water emulsion, producing an adjuvant that elicited potent Th1-biased adaptive responses.	Water	32-37	Src like adaptor	Homo sapiens	0-3
27651294-4	2016	An in silico method for the determination of stabilized water molecules in the binding site of the apo structure of LTA4H is used to interpret the measured thermodynamic data and provided insights for design of novel LTA4H inhibitors.	Water	56-61	leukotriene A4 hydrolase	Homo sapiens	116-121
27651294-4	2016	An in silico method for the determination of stabilized water molecules in the binding site of the apo structure of LTA4H is used to interpret the measured thermodynamic data and provided insights for design of novel LTA4H inhibitors.	Water	56-61	leukotriene A4 hydrolase	Homo sapiens	217-222
27665146-9	2016	RESULTS: Water significantly increased the modulus of NG1 and NG2 dispersed in solvent, while significantly decreased the stiffness of NG3.	Water	9-14	EGF like domain multiple 8	Homo sapiens	135-138
27572691-7	2016	The NO3- isotope value ranges conducted in this study might provide useful information for tracing NO3- sources towards the implementation of efficient water pollution control in Beijing.	Water	152-157	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
27541153-5	2016	The average concentrations of Cr, Cu, Ni, Pb, and Zn in surface pore water were 18.8, 23.4, 12.0, 13.5, and 42.5 mug L-1, respectively.	Water	69-74	immunoglobulin kappa variable 1-16	Homo sapiens	117-120
27591884-15	2016	In the water/sediment systems, from the first day, it degraded into B-1 in the sediment, and in the water mainly degraded into B-3.	Water	7-12	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	68-71
27581046-3	2016	In this paper, the removal of IBP from simulated water streams was investigated by using a lab-scale experimental device, consisting of a batch reactor equipped with a lamp emitting monochromatic UV light at a fixed wavelength (254 nm) and various intensities.	Water	49-54	DEF6 guanine nucleotide exchange factor	Homo sapiens	30-33
27572691-7	2016	The NO3- isotope value ranges conducted in this study might provide useful information for tracing NO3- sources towards the implementation of efficient water pollution control in Beijing.	Water	152-157	NBL1, DAN family BMP antagonist	Homo sapiens	99-102
27124387-2	2016	To aid our understanding of N transformations on the catchment level, we studied spatial and temporal variabilities of concentration and natural abundance (delta15 N and delta18 O) of nitrate (NO3- ) in soil pore water along a hydrological continuum in the N-saturated Tieshanping (TSP) catchment, southwest China.	Water	213-218	NBL1, DAN family BMP antagonist	Homo sapiens	193-196
27061931-6	2016	Following exposure of rats to a concentration of a pharmaceutical which was 10 times higher than the concentration known to be present in tap water, trace levels of some pharmaceuticals and their metabolites were detected in biological samples.	Water	142-147	nuclear RNA export factor 1	Rattus norvegicus	138-141
27131391-3	2016	The Corexit-enhanced Water Accommodated Fraction (CWAF) of DWH crude oil contains PPARgamma transactivation activity, which is attributed to dioctyl sodium sulfosuccinate (DOSS), a probable obesogen.	Water	21-26	peroxisome proliferator activated receptor gamma	Homo sapiens	82-91
27124387-7	2016	Episode studies in the summers of 2009, 2010 and 2013 revealed that the spatial pattern of delta15 N and delta18 O-NO3- in soil water was remarkably similar from year to year.	Water	128-133	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
27377460-1	2016	A water-soluble polysaccharide (BP-1) was obtained from highland barley (Hordeum vulgare L.) by hot water extraction and purification of sepharose column chromatography.	Water	2-7	BP1	Homo sapiens	32-36
27632703-4	2016	In the present study, we demonstrated that a water-soluble bis-malonic acid fullerene derivative (C60-dicyclopropane-1,1,1",1"-tetracarboxylic acid) markedly diminished the IL-33-induced expression of IL-6 in bone marrow-derived mast cells (BMMC).	Water	45-50	interleukin 6	Homo sapiens	201-205
27019209-5	2016	Further the structural behavior of native and mutant MATP protein was investigated by molecular dynamics simulation (MDS) approach in explicit lipid and water background.	Water	153-158	solute carrier family 45 member 2	Homo sapiens	53-57
27633738-1	2016	Cytochrome c oxidase (CcO) catalyzes the exothermic reduction of O2 to H2O by using electrons from cytochrome c, and hence plays a crucial role in ATP production.	Water	71-74	cytochrome c, somatic	Homo sapiens	0-12
27633738-1	2016	Cytochrome c oxidase (CcO) catalyzes the exothermic reduction of O2 to H2O by using electrons from cytochrome c, and hence plays a crucial role in ATP production.	Water	71-74	cytochrome c, somatic	Homo sapiens	99-111
27422225-11	2016	Higher levels of mRNA expression of COL IV, MMP9, and TGFbeta were verified in water bath-processed resin, which were similar to those in the nonstimulated group.	Water	79-84	transforming growth factor beta 1	Homo sapiens	54-61
27569448-1	2016	As a model for human tissue, this report considers the rate of free radical generation in a dilute solution of water in which a beta-emitting radionuclide is uniformly dispersed.	Water	111-116	amyloid beta precursor protein	Homo sapiens	126-132
27524082-4	2016	The resulting SPI/rGO nanocomposites disperse in water very well and exhibit good biocompatibility due to the attachment of SPI to the surface of rGO.	Water	49-54	chromogranin A	Homo sapiens	14-17
27524021-7	2016	The prepared membranes were treated with solutions of bovine serum albumin (BSA) in de-ionized water at 37 C at a pH of 7.2.	Water	95-100	albumin	Homo sapiens	61-74
27609422-1	2016	PIP1;2 and PIP2;1 are aquaporins that are highly expressed in roots and bring a major contribution to root water transport and its regulation by hormonal and abiotic factors.	Water	107-112	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	0-6
27609422-3	2016	Proteins that molecularly interact with PIP1;2 and PIP2;1 were searched to get new insights into regulatory mechanisms of root water transport.	Water	127-132	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	40-46
27280935-4	2016	Expression of the bone-remodeling marker osteocalcin production and bone microstructural parameters were significantly improved in Sprague-Dawley rats in vivo after oral treatment with the hot-water extract compared with their control (saline-administered) counterparts.	Water	193-198	bone gamma-carboxyglutamate protein	Rattus norvegicus	41-52
27899683-4	2016	By manipulating vascular tone and regulating water reabsorption in the collecting duct of the kidneys, vasopressin can mediate the retention or loss of fluids quickly.	Water	45-50	arginine vasopressin	Homo sapiens	103-114
29786178-4	2016	The retrieved bioaccumulation factor (BAF) indicated that N. Stolatus has high potential to be a biomonitor for the contaminations of Fe and Mn in water and Cd, Ni and Pb in sediment.	Water	147-152	BAF nuclear assembly factor 1	Homo sapiens	38-41
27577115-6	2016	Leaves of the myb94 myb96 mutant lost water through the cuticle faster than those of myb94 or myb96 plants.	Water	38-43	myb domain protein 94	Arabidopsis thaliana	14-19
27448794-3	2016	Here, we examined 12C/13C, 14N/15N and H2O/D2O isotope effects in Arabidopsis GS1 catalysis and compared to the prokaryotic (Escherichia coli) enzyme.	Water	39-42	Haloacid dehalogenase-like hydrolase (HAD) superfamily protein	Arabidopsis thaliana	78-81
27466288-0	2016	Repeated Water Avoidance Stress Alters Mucosal Mast Cell Counts, Interleukin-1beta Levels with Sex Differences in the Distal Colon of Wistar Rats.	Water	9-14	interleukin 1 beta	Rattus norvegicus	65-82
28003711-7	2016	Plasma water T2 can detect shifts in the blood proteome resulting from inflammation, insulin resistance and dyslipidemia.	Water	7-12	insulin	Homo sapiens	85-92
27568398-6	2016	Based on the Z eff data and the continuous momentum transfer range (10-2-109 A-1), MAGIC, PAGAT and soft tissue were found to be water-equivalent materials, since their differences (%) relative to water are significantly low (&lt;=3.2 % for MAGIC up to 103 A-1, &lt;=2.9 % for PAGAT up to 109 A-1, and &lt;=3.8 % for soft tissue up to 109 A-1), while the Fricke gel was not found to be water equivalent.	Water	129-134	BCL2 related protein A1	Homo sapiens	77-80
27540626-4	2016	Like other clathrate hydrates and forms of ice, the protons of H2O molecules within C0 are disordered.	Water	63-66	carboxylesterase 2	Homo sapiens	43-46
27799072-3	2016	Aquaporin, AQP1, allows water transfer across the apical surface of the choroid epithelium; another protein, perhaps GLUT1, is important on the basolateral surface.	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	11-15
27782212-0	2016	A Carbonaceous Membrane based on a Polymer of Intrinsic Microporosity (PIM-1) for Water Treatment.	Water	82-87	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	71-76
27734039-2	2016	We investigate the hydrogen-bond configuration and dynamics of water in triacetin, tributyrin and trioctanoin using linear infrared and time-resolved two-dimensional infrared (2DIR) spectroscopy of the water hydroxyl stretch vibration.	Water	63-68	arginine vasopressin receptor 2	Homo sapiens	177-180
27722727-1	2016	The synthesis of a novel layered silicate SSA-1 (SSA: silicate synthesized with a quaternary amine) was achieved in the SiO2-H2O-TEAOH (TEAOH: tetraethylammonium hydroxide - as an organic structural directing agent) system.	Water	125-128	tripartite motif containing 21	Homo sapiens	42-47
28352827-0	2016	Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy.	Water	9-14	enolase 2	Homo sapiens	23-26
28352827-0	2016	Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy.	Water	9-14	interleukin 6	Homo sapiens	28-32
28352827-0	2016	Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy.	Water	9-14	tumor necrosis factor	Homo sapiens	38-47
28352827-10	2016	Hydrogen water lowers serum NSE, IL-6, and TNF-alpha levels in HIE newborns, thereby exerting a protective effect.	Water	9-14	enolase 2	Homo sapiens	28-31
28352827-10	2016	Hydrogen water lowers serum NSE, IL-6, and TNF-alpha levels in HIE newborns, thereby exerting a protective effect.	Water	9-14	interleukin 6	Homo sapiens	33-37
28352827-10	2016	Hydrogen water lowers serum NSE, IL-6, and TNF-alpha levels in HIE newborns, thereby exerting a protective effect.	Water	9-14	tumor necrosis factor	Homo sapiens	43-52
27474659-5	2016	The modified chitosan bead was then used in laboratory batch experiments to evaluate the removal of Pb(II) ion from water samples.	Water	116-121	submaxillary gland androgen regulated protein 3B	Homo sapiens	100-106
27659807-8	2016	The film structure at the air-water interface could differentiate the SPC- and HSPC-comprising systems through the formation of organized regions, especially at a higher surface pressure.	Water	30-35	proline rich protein gene cluster	Homo sapiens	70-73
27643514-0	2016	Redox-Assisted Self-Assembly of a Water-Soluble Cyanido-Bridged Mixed Valence {CoIII /FeII }2 Square.	Water	34-39	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	79-84
27700067-3	2016	The best estimates of the Gibbs free energies characterizing the AlF4- and NaF2- fragmentation reactions in a water solvent are evaluated as equal to 33-34 and 12-14 kcal/mol, respectively (assuming the F- and AlF3/NaF products) or 14-15 and 26-28 kcal/mol, respectively (assuming the HF and AlF3OH-/NaFOH- products).	Water	110-115	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
27643514-1	2016	The facile redox-assisted assembly of a water-soluble, extremely robust, cyanide-bridged mixed-valence [{CoIII {(Me)2 (mu-ET)cyclen} }2 {(mu-NC)2 FeII (CN)4 }2 ]2- square is reported.	Water	40-45	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	105-110
27681633-0	2016	Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection.	Water	78-83	caspase 3	Homo sapiens	30-39
27589480-0	2016	Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.	Water	235-240	KISS1 receptor	Rattus norvegicus	55-69
27589480-0	2016	Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.	Water	235-240	KISS1 receptor	Rattus norvegicus	71-77
27733198-0	2016	Gyeji-tang water extract exerts anti-inflammatory activity through inhibition of ERK and NF-kappaB pathways in lipopolysaccharide-stimulated RAW 264.7 cells.	Water	11-16	mitogen-activated protein kinase 1	Mus musculus	81-84
27733198-0	2016	Gyeji-tang water extract exerts anti-inflammatory activity through inhibition of ERK and NF-kappaB pathways in lipopolysaccharide-stimulated RAW 264.7 cells.	Water	11-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-98
27711833-5	2016	In this experiment, aqueous arsenic in released pore water ranged from 17.5 to 21.3 mug L-1 and the accumulated content of the released arsenic was 17.576 mug during the compaction.	Water	53-58	immunoglobulin kappa variable 1-16	Homo sapiens	88-91
27681633-6	2016	Altogether, our database consists of 37 high-resolution structures of caspase-3 variants, and we demonstrate that the decrease in activity correlates with a loss of conserved water molecules.	Water	175-180	caspase 3	Homo sapiens	70-79
29964410-3	2016	The results indicated that the concentration of total PAHs ( PAHs) in the surface water ranged from 17.7-110 ng L-1 with an average value of 42.6 ng L-1.	Water	82-87	immunoglobulin kappa variable 1-16	Homo sapiens	112-115
29964400-6	2016	The water-soluble ionic components of PM2.5 were SO42-, NO3-, NH4+ and K+ which accounted for 40.67%, and the aerosol partial acid.	Water	4-9	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
27465156-4	2016	The effect of AQP1 inhibitors was evaluated through water flow-based tests: osmotic fragility and hypertonic cryohemolysis.	Water	52-57	aquaporin 1 (Colton blood group)	Homo sapiens	14-18
27324423-0	2016	Time-Resolved Fluorescence of Water-Soluble Pyridinium Salt: Sensitive Detection of the Conformational Changes of Bovine Serum Albumin.	Water	30-35	albumin	Homo sapiens	121-134
27716810-2	2016	Only serum growth hormone levels and sex hormone binding globulin (SHBG) were significantly associated with percent breast water after adjustment for covariates.	Water	123-128	growth hormone 1	Homo sapiens	11-25
27716810-2	2016	Only serum growth hormone levels and sex hormone binding globulin (SHBG) were significantly associated with percent breast water after adjustment for covariates.	Water	123-128	sex hormone binding globulin	Homo sapiens	37-65
27716810-2	2016	Only serum growth hormone levels and sex hormone binding globulin (SHBG) were significantly associated with percent breast water after adjustment for covariates.	Water	123-128	sex hormone binding globulin	Homo sapiens	67-71
27716810-7	2016	RESULTS: SHBG was positively associated with percent water in both follicular and luteal phases of the menstrual cycle.	Water	53-58	sex hormone binding globulin	Homo sapiens	9-13
27465156-11	2016	The finding of AQP1 expression induced by Epo in a model of erythroid cells may be interpreted as a mechanism to restore the balance of red cell water fluxes.	Water	145-150	aquaporin 1 (Colton blood group)	Homo sapiens	15-19
27465156-8	2016	Accordingly, red blood cells from HS subjects were less sensitive to cryohemolysis than normal erythrocytes after inhibition of the AQP1 water channel.	Water	137-142	aquaporin 1 (Colton blood group)	Homo sapiens	132-136
27465156-11	2016	The finding of AQP1 expression induced by Epo in a model of erythroid cells may be interpreted as a mechanism to restore the balance of red cell water fluxes.	Water	145-150	erythropoietin	Homo sapiens	42-45
27418061-2	2016	The CASR may also influence electrolyte and water homeostasis.	Water	44-49	calcium sensing receptor	Homo sapiens	4-8
27265400-9	2016	TPs 1 underwent a series of photochemical reactions involving ring-opening, addition of one H2O molecule and demethylation on three-member ring to form TPs 2, which was further hydroxylated on benzene ring to form TPs 6.	Water	92-95	tryptase alpha/beta 1	Homo sapiens	0-5
27380224-0	2016	Cloning of scFv from hybridomas using a rational strategy: Application as a receptor to sensitive detection microcystin-LR in water.	Water	126-131	immunglobulin heavy chain variable region	Homo sapiens	11-15
27591797-1	2016	Regulation of ROS metabolism plays a major role in cellular adaptation to oxidative stress in cancer cells, but the molecular mechanism that regulates catalase, a key antioxidant enzyme responsible for conversion of hydrogen peroxide to water and oxygen, remains to be elucidated.	Water	237-242	catalase	Homo sapiens	151-159
27598034-6	2016	Preincubation of MCF-7 cells with trolox, a water-soluble form of vitamin E, attenuated 15d-PGJ2-induced HIF-1alpha expression although HO-1 expression was unchanged.	Water	44-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-115
27358259-14	2016	Improving sanitation by connecting the population to sewers, should be combined with waste water treatment, otherwise (SSP1*) emissions in 2050 are expected to be much larger than in a situation with strong population growth and slow development of safe water and improved sanitation (SSP3).	Water	91-96	SUMO specific peptidase 6	Homo sapiens	119-123
27928437-1	2016	Rationale: Arginine vasopressin (AVP) is secreted under conditions of water deprivation.	Water	70-75	arginine vasopressin	Homo sapiens	11-31
26966319-0	2016	Cold Water Swimming Beneficially Modulates Insulin Sensitivity in Middle-Aged Individuals.	Water	5-10	insulin	Homo sapiens	43-50
27928437-1	2016	Rationale: Arginine vasopressin (AVP) is secreted under conditions of water deprivation.	Water	70-75	arginine vasopressin	Homo sapiens	33-36
27928437-14	2016	In the light of epidemiological data, indicating that more than 50% of the European population has a lower daily water intake and a fraction of 25% displaying high copeptin, our data further sustained that copeptin may be a good biomarker for MetS and/ or obesity, which should be further investigated with other members of the osmoregulation pathway at both pathogenesis and genetic levels.	Water	113-118	arginine vasopressin	Homo sapiens	206-214
27460145-3	2016	We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates alpha3, alpha4, alpha5, alpha6, alpha7, beta2, and beta4 nAChR subunits from human and rat cortical extracts, and rat midbrain and olfactory bulb extracts, suggesting that Lynx1 forms complexes with multiple nAChR subtypes in the human and rodent brain.	Water	53-58	Ly6/neurotoxin 1	Homo sapiens	84-89
27603566-5	2016	In this work, we study the electrostatic loop of SOD1, which we had previously proposed to work as a "solvent seal" isolating the metal site from water molecules.	Water	146-151	superoxide dismutase 1	Homo sapiens	49-53
27474162-4	2016	Results showed bacopaside I blocked both the water (IC50 117 muM) and ion channel activities of AQP1 but did not alter AQP4 activity, whereas bacopaside II selectively blocked the AQP1 water channel (IC50 18 muM) without impairing the ionic conductance.	Water	185-190	aquaporin 1 (Colton blood group)	Homo sapiens	180-184
27474162-1	2016	Aquaporin-1 (AQP1) is a major intrinsic protein that facilitates flux of water and other small solutes across cell membranes.	Water	73-78	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
27474162-1	2016	Aquaporin-1 (AQP1) is a major intrinsic protein that facilitates flux of water and other small solutes across cell membranes.	Water	73-78	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
27526028-5	2016	A single glucuronic acid-beta1,3-xylose disaccharide repeat straddles a Ca(2+) ion in the LG4 domain, with oxygen atoms from both sugars replacing Ca(2+)-bound water molecules.	Water	160-165	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	25-32
27618652-6	2016	Ex vivo culture of human adult peripheral T cells with sterile fecal water from NGM3 subjects increased the proportion of CD4+ cells producing interleukin (IL)-4 and reduced the relative abundance of CD4+CD25+FOXP3+ cells.	Water	69-74	interleukin 4	Homo sapiens	143-161
27618652-6	2016	Ex vivo culture of human adult peripheral T cells with sterile fecal water from NGM3 subjects increased the proportion of CD4+ cells producing interleukin (IL)-4 and reduced the relative abundance of CD4+CD25+FOXP3+ cells.	Water	69-74	CD4 molecule	Homo sapiens	122-125
27460145-3	2016	We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates alpha3, alpha4, alpha5, alpha6, alpha7, beta2, and beta4 nAChR subunits from human and rat cortical extracts, and rat midbrain and olfactory bulb extracts, suggesting that Lynx1 forms complexes with multiple nAChR subtypes in the human and rodent brain.	Water	53-58	Ly6/neurotoxin 1	Homo sapiens	91-99
27618652-6	2016	Ex vivo culture of human adult peripheral T cells with sterile fecal water from NGM3 subjects increased the proportion of CD4+ cells producing interleukin (IL)-4 and reduced the relative abundance of CD4+CD25+FOXP3+ cells.	Water	69-74	CD4 molecule	Homo sapiens	200-203
27618652-7	2016	12,13-DiHOME, enriched in NGM3 versus lower-risk NGM states, recapitulated the effect of NGM3 fecal water on relative CD4+CD25+FOXP3+ cell abundance.	Water	100-105	CD4 molecule	Homo sapiens	118-121
27460145-3	2016	We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates alpha3, alpha4, alpha5, alpha6, alpha7, beta2, and beta4 nAChR subunits from human and rat cortical extracts, and rat midbrain and olfactory bulb extracts, suggesting that Lynx1 forms complexes with multiple nAChR subtypes in the human and rodent brain.	Water	53-58	immunoglobulin kappa variable 2D-28	Homo sapiens	110-116
27460145-3	2016	We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates alpha3, alpha4, alpha5, alpha6, alpha7, beta2, and beta4 nAChR subunits from human and rat cortical extracts, and rat midbrain and olfactory bulb extracts, suggesting that Lynx1 forms complexes with multiple nAChR subtypes in the human and rodent brain.	Water	53-58	glycoprotein hormone subunit alpha 2	Homo sapiens	150-155
27434879-8	2016	Moreover the chemical composition of the femur, tibia and L-4 vertebra - content of water, organic substances and minerals - was determined.	Water	84-89	ribosomal protein L3	Rattus norvegicus	58-61
27260326-7	2016	In contrast, sulpiride increased DA release in the NACsh more in the "Water" than "EtOH" groups (e.g., 200 muM sulpiride: to ~ 190-240 vs 150-160% of baseline).	Water	70-75	latexin	Homo sapiens	107-110
27418661-7	2016	TWFR, 45 min of transport, 1 h rest, and addition of sodium bicarbonate (TRB) and TRT induced T22 (relaxation time of water trapped within myofibrils) shift to shorter relaxation time and narrower relaxation distribution compared with TR.	Water	118-123	T cell receptor beta locus	Homo sapiens	73-76
27376416-1	2016	AIM: We examined whether cold water swimming for seven consecutive months changes basal leptin and insulin concentrations and insulin sensitivity in healthy non-obese women.	Water	30-35	insulin	Homo sapiens	99-106
27376416-9	2016	CONCLUSION: Regular cold water swimming may stimulate metabolic changes suggesting that leptin and insulin participate in adaptive metabolic mechanisms triggered by repeated cold exposure accompanied by mild exercise in healthy non-obese women.	Water	25-30	insulin	Homo sapiens	99-106
27627089-4	2016	The changes of the total water volume (CTV) and ABB may be presented at the same time in the values of the difference and ratio between serum concentrations of natrium and chlorides (SNa+ - SCl-; SNa+/SCl-).	Water	25-30	snail family transcriptional repressor 1	Homo sapiens	183-186
27267715-9	2016	Fecal indicator bacteria in surface water along different creeks and channels were significantly correlated with pH (P&lt;0.01), NO2 (P&lt;0.03), and NH4N (P&lt;0.005); and in the sediment with NO3 (P&lt;0.015).	Water	36-41	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
27320738-8	2016	The combined fresh and saline groundwater fluxes of NO3, PO4, NH4, DON, DOP, TDN and TDP were estimated to account for 66, 58, 55, 31, 21, 53 and 47% of surface water exports, respectively.	Water	36-41	NBL1, DAN family BMP antagonist	Homo sapiens	52-55
27344251-6	2016	The occurrence of phenylacetonitrile as an N-DBP in tap water was investigated for the first time; the results revealed that mug/L concentrations were present in nine different distributed drinking waters in China and the United States.	Water	56-61	D-box binding PAR bZIP transcription factor	Homo sapiens	45-48
27627089-4	2016	The changes of the total water volume (CTV) and ABB may be presented at the same time in the values of the difference and ratio between serum concentrations of natrium and chlorides (SNa+ - SCl-; SNa+/SCl-).	Water	25-30	snail family transcriptional repressor 1	Homo sapiens	196-199
27608266-4	2016	Reconstituted SPI-SSPS particles might rearrange and link each other due to the presence of SSPS on the air-water interface to better stabilize these systems.	Water	108-113	chromogranin A	Homo sapiens	14-17
27584158-6	2016	The strong attractive interactions between ND, tRNA, and water give rise to unlike dynamical behavior and structural changes of tRNA in front of ND compared to without ND.	Water	57-62	mitochondrially encoded tRNA glycine	Homo sapiens	128-132
27528256-3	2016	Simple mixing of transferrin and indocyanine green enables their self-assembly in aqueous solution to form nanoparticles with excellent water solubility, colloidal stability, favorable biocompatibility and impressive active targeting theranostic effects in vitro and in vivo.	Water	136-141	transferrin	Homo sapiens	17-28
27680940-3	2016	Here we show that the sleep period in mice (Zeitgeber time, ZT0-12) is preceded by an increase in water intake promoted entirely by the central clock, and not motivated by physiological need.	Water	98-103	circadian locomotor output cycles kaput	Mus musculus	144-149
27666869-3	2016	Mild edge oxidation guarantees that the pristine sp2 lattice is largely intact and the edges are functionalized with hydrophilic groups, giving rise to high conductivity and good water dispersibility at the same time.	Water	179-184	Sp2 transcription factor	Homo sapiens	49-52
27575543-1	2016	Hofmeister anion effects on adsorption kinetics of the positively charged lysozyme (pH &lt; pI) at an air-water interface were studied by surface tension measurements and time-resolved X-ray reflectometry.	Water	106-111	lysozyme	Homo sapiens	74-82
27575543-5	2016	In X-ray reflection studies, we observed that the lysozyme molecules initially adsorbed on the air-water interface have a flat unfolded structure as previously reported in the salt-free solution.	Water	99-104	lysozyme	Homo sapiens	50-58
27583975-1	2016	Multiple moderate-resolution crystal structures of human aquaporin-1 have provided a foundation for understanding the molecular mechanism of selective water translocation in human cells.	Water	151-156	aquaporin 1 (Colton blood group)	Homo sapiens	57-68
27583975-6	2016	The simulations reveal loop stabilizing interactions that alter the extracellular surface of human AQP1, with possible implications for water transport regulation through the channel.	Water	136-141	aquaporin 1 (Colton blood group)	Homo sapiens	99-103
27583975-7	2016	Modulation of water permeation may occur as a result of rearrangement of side chains from loop C in the extracellular vestibule of hAQP1, affecting the aromatic arginine selectivity filter.	Water	14-19	aquaporin 1 (Colton blood group)	Homo sapiens	131-136
27656877-13	2016	There are significant changes of SP-A and SP-C levels in diseases affecting brain water circulation and elevation of intracranial pressure.	Water	82-87	surfactant protein C	Homo sapiens	42-46
27261754-1	2016	The polysaccharide gel layer surrounding hydrated chia seeds was extracted using water and isolated by ethanol precipitation.	Water	81-86	chitinase acidic	Homo sapiens	50-54
27669248-2	2016	Here, we present the development of a simple fluorescence biosensor based on water-soluble MoS2 nanosheets and restriction endonuclease BstUI for methylation analysis of p16 promoter.	Water	77-82	cyclin dependent kinase inhibitor 2A	Homo sapiens	170-173
27722290-0	2016	Activity and conformation of lysozyme in molecular solvents, protic ionic liquids (PILs) and salt-water systems.	Water	98-103	lysozyme	Homo sapiens	29-37
27722290-8	2016	Due to the presence of a net surface charge on lysozyme, electrostatic interactions in PIL-water systems and salt solutions enhanced lysozyme activity more than the specific hydrogen-bond interactions present in non-ionic molecular solvents.	Water	91-96	lysozyme	Homo sapiens	47-55
27530898-2	2016	When SC1, SC2, and SC3 were suspended in water, the entrapped [Ru(bipy)3 ]2+ dye was free to diffuse from the inner pores to the solution.	Water	41-46	trans-2,3-enoyl-CoA reductase	Homo sapiens	10-13
27722290-8	2016	Due to the presence of a net surface charge on lysozyme, electrostatic interactions in PIL-water systems and salt solutions enhanced lysozyme activity more than the specific hydrogen-bond interactions present in non-ionic molecular solvents.	Water	91-96	lysozyme	Homo sapiens	133-141
27722290-11	2016	Preferential solvophobic effects along with bulky chemical structures were postulated to result in less competition with water at the specific hydration layer around the protein, thus reducing protein-solvent interactions and retaining lysozyme"s native conformation.	Water	121-126	lysozyme	Homo sapiens	236-244
27653479-11	2016	Accordingly, N133 can work as a molecular microswitch driving the change between the inactive and active NOP conformations, in the framework of an extended H-bond and water network rearrangement in the deep binding site.	Water	167-172	prepronociceptin	Homo sapiens	105-108
27524245-1	2016	Major intrinsic protein or aquaporin-0 (MIP/AQP0) functions as a water channel and a cell-junction molecule in the vertebrate eye lens.	Water	65-70	major intrinsic protein of lens fiber	Mus musculus	40-43
27336293-0	2016	Air-water partition coefficients for a suite of polycyclic aromatic and other C10 through C20 unsaturated hydrocarbons.	Water	4-9	homeobox C10	Homo sapiens	78-81
27524245-1	2016	Major intrinsic protein or aquaporin-0 (MIP/AQP0) functions as a water channel and a cell-junction molecule in the vertebrate eye lens.	Water	65-70	major intrinsic protein of lens fiber	Mus musculus	44-48
27510921-1	2016	We hereby describe a strategy for obtaining novel topological nanostructures consisting of dual-cavity basket 1, forming a curved monolayer of large unilamellar vesicles in water (CAC &lt; 0.25 muM), and bivalent guests 4/5 populating the cavities of such bolaamphiphilic hosts.	Water	173-178	latexin	Homo sapiens	194-197
27457417-9	2016	LFABP was able to capture ligands from prokaryotic and eukaryotic cell lysates, and from artificial cells (water-in-oil emulsion droplets).	Water	107-112	fatty acid binding protein 1	Homo sapiens	0-5
27093483-0	2016	Water-soluble gold nanoclusters prepared by protein-ligand interaction as fluorescent probe for real-time assay of pyrophosphatase activity.	Water	0-5	inorganic pyrophosphatase 1	Homo sapiens	115-130
27783857-3	2016	Vasopressin increases water reabsorption in the kidney to maintain body fluid balance and causes vasoconstriction to increase blood pressure.	Water	22-27	arginine vasopressin	Homo sapiens	0-11
27557037-4	2016	The alpha-fluorine-substituted phospholipid analogues are found to be substrates for secretory PLA2, with sufficient accessibility of water to the active site to allow for enzymatic hydrolysis.	Water	134-139	phospholipase A2 group IB	Homo sapiens	95-99
27548572-1	2016	Water dynamics in the hydration shell of the peripheral membrane protein annexin B12 were studied using MD simulations and Overhauser DNP-enhanced NMR.	Water	0-5	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	81-84
29964757-4	2016	In PM1.1 and PM2.1, secondary water-soluble ions (SO42-, NO3- and NH4+) comprised 87.59% and 86.30% of all water-soluble ions, respectively, while in PM9, SO42- and Ca2+ comprised 32.78% and 28.54% of all water-soluble ions, respectively.	Water	30-35	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
27641679-1	2016	Aquaporin-2 (AQP2) is a homotetrameric water channel responsible for the final water reuptake in the kidney.	Water	39-44	aquaporin 2 S homeolog	Xenopus laevis	0-11
27641679-1	2016	Aquaporin-2 (AQP2) is a homotetrameric water channel responsible for the final water reuptake in the kidney.	Water	39-44	aquaporin 2 S homeolog	Xenopus laevis	13-17
27641679-1	2016	Aquaporin-2 (AQP2) is a homotetrameric water channel responsible for the final water reuptake in the kidney.	Water	79-84	aquaporin 2 S homeolog	Xenopus laevis	0-11
27641679-1	2016	Aquaporin-2 (AQP2) is a homotetrameric water channel responsible for the final water reuptake in the kidney.	Water	79-84	aquaporin 2 S homeolog	Xenopus laevis	13-17
27521344-1	2016	Sixty to seventy percent of IFN-gamma(-/-) NOD.H-2h4 mice given sodium iodide (NaI)-supplemented water develop a slow onset autoimmune thyroid disease, characterized by thyrocyte epithelial cell (TEC) hyperplasia and proliferation (H/P).	Water	97-102	interferon gamma	Mus musculus	28-37
30546691-1	2016	Compared with conventional diuretic therapy, monitoring decompensated heart failure (HF) under treatment with a vasopressin antagonist is problematic because (1) use of this medication usually allows the patient free water intake to prevent drug-induced hypernatremia and (2) this medication often induces only minimal changes in the hemodynamics and blood concentration.	Water	217-222	arginine vasopressin	Homo sapiens	112-123
27600292-2	2016	Here, we demonstrated that Sirt1 was mainly expressed in the tubulointerstitial cells of normal rat kidneys and was co-localized with aquaporin 2, indicating it may be involved in water/salt regulation.	Water	180-185	sirtuin 1	Rattus norvegicus	27-32
27500422-3	2016	In both structures, the Co(II) centers adopt octahedral {CoN2O4} geometries filled by pairs of mutually trans terminal 3,5-dnb, py, and water ligands.	Water	136-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
27506305-9	2016	A much smaller water ordering and subsequent reduction upon salt addition was observed for the C18-modified PES, and little water structure change was seen for the unmodified PES.	Water	15-20	Bardet-Biedl syndrome 9	Homo sapiens	95-98
27433926-2	2016	The addition of 1 % H2 O significantly improved the performance of the Co(II) catalyst.	Water	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
27532326-2	2016	In contrast, their reaction with PPh3 in THF/H2O give the amino esters as the major product and no triazoles.	Water	45-48	caveolin 1	Homo sapiens	33-37
27592853-0	2016	Corrigendum: Synthesis and Kinetic Characterisation of Water-Soluble Fluorogenic Acyl Donors for Transglutaminase 2.	Water	55-60	transglutaminase 2	Homo sapiens	97-115
27372901-0	2016	Preferential solvation of lysozyme in dimethyl sulfoxide/water binary mixture probed by terahertz spectroscopy.	Water	57-62	lysozyme	Homo sapiens	26-34
27391702-5	2016	Transmission electron microscope and water contact angle measurement demonstrate that VEGF-HGFI can form a self-assembly layer with about 25 nm in thickness on electrospun PCL fibers and increase their hydrophilicity.	Water	37-42	vascular endothelial growth factor A	Homo sapiens	86-90
27372901-1	2016	We report the changes in the hydration dynamics around a model protein hen egg white lysozyme (HEWL) in water-dimethyl sulfoxide (DMSO) binary mixture using THz time domain spectroscopy (TTDS) technique.	Water	104-109	lysozyme	Homo sapiens	85-93
27460171-4	2016	Molecular docking and dynamics simulation revealed that (i) hydrogen atom of the oxime group interacts with Asp99 of HDAC1 through a water bridged hydrogen bond and (ii) a hydroxyl group is optimal attached on the para-position of benzene, interacting with Glu203 at the entrance to the active site tunnel.	Water	133-138	histone deacetylase 1	Homo sapiens	117-122
27418282-3	2016	By quantifying the number of hydrate water molecules, we provide a microscopic description for the interactions of water with a wild-type p53 TAD and two p53 TAD peptides.	Water	37-42	tumor protein p53	Homo sapiens	138-141
27418282-3	2016	By quantifying the number of hydrate water molecules, we provide a microscopic description for the interactions of water with a wild-type p53 TAD and two p53 TAD peptides.	Water	37-42	tumor protein p53	Homo sapiens	154-157
27418282-3	2016	By quantifying the number of hydrate water molecules, we provide a microscopic description for the interactions of water with a wild-type p53 TAD and two p53 TAD peptides.	Water	115-120	tumor protein p53	Homo sapiens	138-141
27418282-3	2016	By quantifying the number of hydrate water molecules, we provide a microscopic description for the interactions of water with a wild-type p53 TAD and two p53 TAD peptides.	Water	115-120	tumor protein p53	Homo sapiens	154-157
27343265-8	2016	These results suggest that corin-mediated pro-ANP activation may occur in renal segments and that locally produced ANP may act in an autocrine manner to regulate sodium and water reabsorption in situ Our results also point to the proximal convoluted tubules as a major site for local ANP action.	Water	173-178	natriuretic peptide A	Homo sapiens	115-118
27178364-12	2016	Treatment with PGC-1alpha siRNAs significantly decreased the neurological score, ATP concentration, number of mitochondria, expression of NRF-1, TFAM, SOD2, UCP2, and mitochondrial DNA, and increased brain water content and formation of mitochondrial myelin layer structures.	Water	206-211	PPARG coactivator 1 alpha	Rattus norvegicus	15-25
27343265-8	2016	These results suggest that corin-mediated pro-ANP activation may occur in renal segments and that locally produced ANP may act in an autocrine manner to regulate sodium and water reabsorption in situ Our results also point to the proximal convoluted tubules as a major site for local ANP action.	Water	173-178	natriuretic peptide A	Homo sapiens	115-118
26555383-3	2016	The zeta potential value for BSA and CuO nanoparticles with average diameter of around 50 nm at concentration of 10 muM in the deionized (DI) water were -5.8 and -22.5 mV, respectively.	Water	142-147	latexin	Homo sapiens	116-119
30084622-0	2016	[The Interaction Between a New Water-Soluble Meso-Tetrakis(Carboxyl) Zinc(II) Porphyrin and Human Serum Albumin].	Water	31-36	albumin	Homo sapiens	104-111
27598129-0	2016	New Approach in Translational Medicine: Effects of Electrolyzed Reduced Water (ERW) on NF-kappaB/iNOS Pathway in U937 Cell Line under Altered Redox State.	Water	72-77	nitric oxide synthase 2	Homo sapiens	97-101
27341303-9	2016	Emulsification of HSA also protects from gastric digestion probably by the orientation of the HSA molecule, which exposes the majority of pepsin cleaving sites preferably to the hydrophobic part of the oil-water interface.	Water	206-211	albumin	Homo sapiens	18-21
27341303-9	2016	Emulsification of HSA also protects from gastric digestion probably by the orientation of the HSA molecule, which exposes the majority of pepsin cleaving sites preferably to the hydrophobic part of the oil-water interface.	Water	206-211	albumin	Homo sapiens	94-97
27344086-7	2016	In general, PFAS concentrations in surface water samples were lower than those in bottom water samples.	Water	43-48	phosphoribosylformylglycinamidine synthase	Homo sapiens	12-16
27349833-7	2016	Our results show that the food-sourced CNP had various metabolic fluxes through urban systems, with carbon mostly emitted into the air and nitrogen and phosphorus mostly discharged into landfills and water.	Water	200-205	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	39-42
27539621-10	2016	What is New:   Two novel mutations of the AVP gene are reported   The importance of molecular testing in children with polyuria and inconclusive water deprivation test is emphasized.	Water	145-150	arginine vasopressin	Homo sapiens	42-45
27467966-3	2016	The subcritical water (SW) treatment provides an efficient technique to solubilize and achieve the enrichment of rutin in soy protein isolate (SPI) by inducing their complexation.	Water	16-21	chromogranin A	Homo sapiens	143-146
27467966-5	2016	SW treatment had much enhanced rutin-combined capacity of SPI than that of conventional method, ascribing to the well-contacted for higher water solubility of rutin with stronger collision-induced hydrophobic interactions.	Water	139-144	chromogranin A	Homo sapiens	58-61
26878881-8	2016	Plain water could be tap (18 %) or bottled (16 %).	Water	6-11	SEC14 like lipid binding 2	Homo sapiens	21-24
27598621-6	2016	Functional assays in oocytes showed that NIP4;1 and NIP4;2 transport water and nonionic solutes.	Water	69-74	NOD26-like intrinsic protein 4;2	Arabidopsis thaliana	52-58
26282188-0	2016	CFTR genotype-related body water and electrolyte balance during a marathon.	Water	27-32	CF transmembrane conductance regulator	Homo sapiens	0-4
27410458-0	2016	Rate of Homogenous Nucleation of Ice in Supercooled Water.	Water	52-57	carboxylesterase 2	Homo sapiens	33-36
27479029-3	2016	To demonstrate this, the flipping motion of aromatic rings of F10 and Y97 amino acid residues of cytochrome c has been studied in glycerol/water mixtures by cross relaxation-suppressed exchange nuclear magnetic resonance spectroscopy.	Water	139-144	cytochrome c, somatic	Homo sapiens	97-109
27531910-6	2016	Using a novel ex vivo human dendritic cell and T-cell coculture assay, we showed that exposure to fecal water from UC patients caused significant Th2 skewing in CD4(+) T-cell populations compared to that of healthy participants.	Water	104-109	CD4 molecule	Homo sapiens	161-164
27602027-2	2016	Some bacteria use N-acyl-L-homoserine lactone (AHL) mediated quorum sensing (QS) to regulate chitinase production in order to catalyze the cleavage of chitin polymers into water soluble N-acetyl-D-glucosamine (NAG) monomers.	Water	172-177	N-acetyl-alpha-glucosaminidase	Homo sapiens	210-213
27107233-4	2016	Cyclic sorption batches showed that 1kg HMO@GO can treat at least 22m(3) Pb(II)-laden synthetic industrial drainage (5mgL(-1) Pb(II)) and 40m(3) drinking water (0.5mgL(-1) Pb(II)) to their corresponding limits (0.1mgL(-1) for wastewater and 10mugL(-1) for drinking water) enforced in China.	Water	154-159	submaxillary gland androgen regulated protein 3B	Homo sapiens	73-79
27107233-4	2016	Cyclic sorption batches showed that 1kg HMO@GO can treat at least 22m(3) Pb(II)-laden synthetic industrial drainage (5mgL(-1) Pb(II)) and 40m(3) drinking water (0.5mgL(-1) Pb(II)) to their corresponding limits (0.1mgL(-1) for wastewater and 10mugL(-1) for drinking water) enforced in China.	Water	154-159	submaxillary gland androgen regulated protein 3B	Homo sapiens	126-132
27107233-4	2016	Cyclic sorption batches showed that 1kg HMO@GO can treat at least 22m(3) Pb(II)-laden synthetic industrial drainage (5mgL(-1) Pb(II)) and 40m(3) drinking water (0.5mgL(-1) Pb(II)) to their corresponding limits (0.1mgL(-1) for wastewater and 10mugL(-1) for drinking water) enforced in China.	Water	154-159	submaxillary gland androgen regulated protein 3B	Homo sapiens	126-132
27006216-0	2016	Characterization of catechin-alpha-lactalbumin conjugates and the improvement in beta-carotene retention in an oil-in-water nanoemulsion.	Water	118-123	lactalbumin alpha	Homo sapiens	29-46
27107233-4	2016	Cyclic sorption batches showed that 1kg HMO@GO can treat at least 22m(3) Pb(II)-laden synthetic industrial drainage (5mgL(-1) Pb(II)) and 40m(3) drinking water (0.5mgL(-1) Pb(II)) to their corresponding limits (0.1mgL(-1) for wastewater and 10mugL(-1) for drinking water) enforced in China.	Water	231-236	submaxillary gland androgen regulated protein 3B	Homo sapiens	73-79
27107233-4	2016	Cyclic sorption batches showed that 1kg HMO@GO can treat at least 22m(3) Pb(II)-laden synthetic industrial drainage (5mgL(-1) Pb(II)) and 40m(3) drinking water (0.5mgL(-1) Pb(II)) to their corresponding limits (0.1mgL(-1) for wastewater and 10mugL(-1) for drinking water) enforced in China.	Water	231-236	submaxillary gland androgen regulated protein 3B	Homo sapiens	126-132
27107233-4	2016	Cyclic sorption batches showed that 1kg HMO@GO can treat at least 22m(3) Pb(II)-laden synthetic industrial drainage (5mgL(-1) Pb(II)) and 40m(3) drinking water (0.5mgL(-1) Pb(II)) to their corresponding limits (0.1mgL(-1) for wastewater and 10mugL(-1) for drinking water) enforced in China.	Water	231-236	submaxillary gland androgen regulated protein 3B	Homo sapiens	126-132
27399642-3	2016	The atomic charges were derived in the context of the SPC/Eb water model, which yields more-accurate rotational diffusion of proteins and enables direct calculation of nuclear magnetic resonance (NMR) relaxation parameters from molecular dynamics simulations.	Water	61-66	proline rich protein gene cluster	Homo sapiens	54-57
27454810-2	2016	In several cases, even the neutral ligands, in addition to their protonated HL(+) and H2L(2+) (L = L1 and L2) forms, bind anions such as F(-), NO3(-), PF6(-), ClO4(-), and SO4(2-) to form stable complexes in water.	Water	208-213	L1 cell adhesion molecule	Homo sapiens	99-108
27419849-2	2016	We describe here a robust type of chemical-reaction-based supramolecular fluorescent nanoprobes for ratiometric determination of CS2 with high selectivity and sensitivity in water medium.	Water	174-179	chorionic somatomammotropin hormone 2	Homo sapiens	129-132
27409519-6	2016	We apply our approach to simulate a hybrid SPC/MARTINI water system and show that the essential properties of water are correctly reproduced with respect to the standard monoscale simulations.	Water	110-115	proline rich protein gene cluster	Homo sapiens	43-46
27503057-4	2016	In the structural investigations of lipid bilayer"s response to Abeta binding, Small Angle Neutron Scattering and Neutron Membrane Diffraction revealed that the Abeta anchors firmly to the highly charged DMPG bilayers in the interfacial region between water and hydrocarbon chain, and it doesn"t penetrate deeply into the bilayer.	Water	252-257	amyloid beta precursor protein	Homo sapiens	161-166
27283776-7	2016	After treatment with anti-CKLF1 antibody, brain water content and Evans blue leakage in ipsilateral hemisphere were decreased in a dose-dependent manner at 24h after reperfusion, but not changed in contralateral hemisphere.	Water	48-53	chemokine-like factor	Rattus norvegicus	26-31
27377167-1	2016	A SrLiAl3 N4 :Eu(2+) (SLA) red phosphor prepared through a high-pressure solid-state reaction was coated with an organosilica layer with a thickness of 400-600 nm to improve its water resistance.	Water	178-183	Src like adaptor	Homo sapiens	22-25
27346782-1	2016	In this paper, a biocompatible and water-soluble fluorescent fullerene (C60-TEG-COOH) coated mesoporous silica nanoparticle (MSN) was successfully fabricated for pH-sensitive drug release and fluorescent cell imaging.	Water	35-40	moesin	Homo sapiens	125-128
27346782-2	2016	The MSN was first reacted with 3-aminopropyltriethoxysilane to obtain an amino-modified MSN, and then the water-soluble C60 with a carboxyl group was used to cover the surface of the MSN through electrostatic interaction with the amino group in PBS solution (pH = 7.4).	Water	106-111	moesin	Homo sapiens	4-7
27252474-4	2016	The induction of water intake by TRPV1-KO mice was normal, whereas intake by TRPV4-KO and Nax-KO mice was significantly less than that by WT mice.	Water	17-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	33-38
27142255-4	2016	It was observed that these four hydrogels showed varied diffusion behavior for either negatively charged BSA or positively charged LYZ due to protein-polymer interaction and the free water content in hydrogel matrix.	Water	183-188	lysozyme	Homo sapiens	131-134
27142255-8	2016	STATEMENT OF SIGNIFICANCE: This work shows that the relative stronger interaction between protein-PEG than protein-pSBMA could increase protein loading efficiency and control release rate by the change ratio of PEG to SBMA in the hydrogel, while the free water (freezable water) content in low cross-linked hydrogel, not the equilibrium water content (EWC), is a more accurate parameter to reflect the diffusion behavior of protein molecules.	Water	255-260	androgen receptor	Homo sapiens	116-120
27142255-8	2016	STATEMENT OF SIGNIFICANCE: This work shows that the relative stronger interaction between protein-PEG than protein-pSBMA could increase protein loading efficiency and control release rate by the change ratio of PEG to SBMA in the hydrogel, while the free water (freezable water) content in low cross-linked hydrogel, not the equilibrium water content (EWC), is a more accurate parameter to reflect the diffusion behavior of protein molecules.	Water	272-277	androgen receptor	Homo sapiens	116-120
27142255-8	2016	STATEMENT OF SIGNIFICANCE: This work shows that the relative stronger interaction between protein-PEG than protein-pSBMA could increase protein loading efficiency and control release rate by the change ratio of PEG to SBMA in the hydrogel, while the free water (freezable water) content in low cross-linked hydrogel, not the equilibrium water content (EWC), is a more accurate parameter to reflect the diffusion behavior of protein molecules.	Water	272-277	androgen receptor	Homo sapiens	116-120
27252474-3	2016	We herein investigated voluntary water intake immediately induced after an intracerebroventricular administration of a hypertonic NaCl solution in TRPV1-, TRPV4-, Nax-, and their double-gene knockout (KO) mice.	Water	33-38	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	147-152
27306979-1	2016	The antidiuretic hormone vasopressin (AVP) regulates renal salt and water reabsorption along the distal nephron and collecting duct system.	Water	68-73	arginine vasopressin	Rattus norvegicus	25-36
27539901-8	2016	The AHR agonist, VAF347, and water-soluble tobacco smoke extract induced melanoblast maturation and AHR activation.	Water	29-34	aryl-hydrocarbon receptor	Mus musculus	100-103
27306979-3	2016	Inactivating mutations in the V2R gene lead to the X-linked form of nephrogenic diabetes insipidus (NDI), which has chiefly been related with impaired aquaporin 2-mediated water reabsorption in the collecting ducts.	Water	172-177	arginine vasopressin receptor 2	Rattus norvegicus	30-33
27155571-1	2016	Major intrinsic protein (MIP) is a functional water-channel (AQP0) that also plays a key role in establishing lens fiber cell architecture.	Water	46-51	major intrinsic protein of lens fiber	Mus musculus	25-28
27155571-1	2016	Major intrinsic protein (MIP) is a functional water-channel (AQP0) that also plays a key role in establishing lens fiber cell architecture.	Water	46-51	major intrinsic protein of lens fiber	Mus musculus	61-65
27591875-1	2016	Positive reaction of the bronchi to distilled water inhalation in asthmatics is associated with significant stimulation of the respiratory epithelium desquamation against the background of increased content of eosinophilic and neutrophilic leukocytes in induced sputum, predomination of eosinophil and neutrophil cytolysis, and lower activity of myeloperoxidase in leukocyte granules (in comparison with the parameter in patients with a negative response to bronchostimulation).	Water	46-51	myeloperoxidase	Homo sapiens	346-361
27358027-3	2016	The haemodynamic and non-haemodynamic effects of Ang II, including its ability to regulate blood pressure, maintain water-electrolyte balance and promote vasoconstriction and cellular growth are well-documented to be mediated primarily by the AT1R.	Water	116-121	angiotensinogen	Homo sapiens	49-55
27254006-6	2016	To test the functional role of brain mTORC1 in mediating the action of Ang II, we examined the consequence of mTORC1 inhibition with rapamycin on Ang II-induced increase in water intake and arterial pressure.	Water	173-178	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	146-152
27254006-7	2016	ICV pretreatment with rapamycin blocked ICV Ang II-mediated increases in the frequency, duration, and amount of water intake but did not interfere with the pressor response evoked by Ang II.	Water	112-117	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	44-50
26526333-2	2016	AQP6, which has low water permeability and transports mainly anions, was recently discovered in the eyes.	Water	20-25	aquaporin 6	Rattus norvegicus	0-4
26526333-6	2016	Therefore, AQP6 might participate in water and anion transport in these cells.	Water	37-42	aquaporin 6	Rattus norvegicus	11-15
27456694-6	2016	In 26 % of the water samples, nitrate concentration is above the human-affected value, 5 mg/l NO3 (-).	Water	15-20	NBL1, DAN family BMP antagonist	Homo sapiens	94-97
27339748-7	2016	Changes in spatial distributions of phosphorylated APQ0 Ser235 and MP20 Ser170 correlated with regions of physiological interest in aged lenses, specifically, where barriers to water transport and extracellular diffusion form.	Water	177-182	lens intrinsic membrane protein 2	Homo sapiens	67-71
27143639-5	2016	The administration of exogenous water-soluble CoQ10 to aged mice via drinking water restored the mitochondrial OCR, motor function, and phosphorylated alpha-syn and VGluT1 levels in the motor cortex.	Water	32-37	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	Mus musculus	165-171
27143639-5	2016	The administration of exogenous water-soluble CoQ10 to aged mice via drinking water restored the mitochondrial OCR, motor function, and phosphorylated alpha-syn and VGluT1 levels in the motor cortex.	Water	78-83	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	Mus musculus	165-171
27291352-0	2016	BAX, a novel cell pro-apoptotic protein, involved in hemocytes early antiviral immune response in fresh water crayfish, Procambarus clarkii.	Water	104-109	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
26071133-7	2016	Risk factors for IGE included younger age, pre-existing dyspepsia-like symptoms, anxiety and drinking contaminated tap water.	Water	119-124	SEC14 like lipid binding 2	Homo sapiens	115-118
27498581-0	2016	Bio-compatibility and cytotoxicity studies of water-soluble CuInS2-ZnS-AFP fluorescence probe in liver cancer cells.	Water	46-51	alpha fetoprotein	Homo sapiens	71-74
26999313-1	2016	UNLABELLED: The adenoviral gene transfer of human aquaporin-1 (hAQP1) water channels to the liver of 17alpha-ethinylestradiol-induced cholestatic rats improves bile flow, in part by enhancing canalicular hAQP1-mediated osmotic water secretion.	Water	70-75	aquaporin 1 (Colton blood group)	Homo sapiens	50-61
26999313-1	2016	UNLABELLED: The adenoviral gene transfer of human aquaporin-1 (hAQP1) water channels to the liver of 17alpha-ethinylestradiol-induced cholestatic rats improves bile flow, in part by enhancing canalicular hAQP1-mediated osmotic water secretion.	Water	70-75	aquaporin 1 (Colton blood group)	Homo sapiens	63-68
26999313-1	2016	UNLABELLED: The adenoviral gene transfer of human aquaporin-1 (hAQP1) water channels to the liver of 17alpha-ethinylestradiol-induced cholestatic rats improves bile flow, in part by enhancing canalicular hAQP1-mediated osmotic water secretion.	Water	70-75	aquaporin 1 (Colton blood group)	Homo sapiens	204-209
26999313-1	2016	UNLABELLED: The adenoviral gene transfer of human aquaporin-1 (hAQP1) water channels to the liver of 17alpha-ethinylestradiol-induced cholestatic rats improves bile flow, in part by enhancing canalicular hAQP1-mediated osmotic water secretion.	Water	227-232	aquaporin 1 (Colton blood group)	Homo sapiens	50-61
26999313-1	2016	UNLABELLED: The adenoviral gene transfer of human aquaporin-1 (hAQP1) water channels to the liver of 17alpha-ethinylestradiol-induced cholestatic rats improves bile flow, in part by enhancing canalicular hAQP1-mediated osmotic water secretion.	Water	227-232	aquaporin 1 (Colton blood group)	Homo sapiens	63-68
27082037-4	2016	We raised the question whether aquaporin 9 expression may be upregulated in placenta from gestational diabetes, thus providing a faster transport of glycerol and water through placenta.	Water	162-167	aquaporin 9	Homo sapiens	31-42
27600972-2	2016	The objective of the present study was to examine the ability of water soluble extracts (WSE) obtained from traditional Greek yoghurt made from bovine or ovine milk to modulate the expression of u-PA, u-PAR, PAI-1 and PAI-2 in ovine monocytes and neutrophils.	Water	65-70	plasminogen activator, urokinase receptor	Bos taurus	201-206
27283495-3	2016	Strong evidence suggests that certain hormones (vasopressin), foods (fructose), and metabolic products (uric acid) function as survival signals to help reduce water loss and store fat (which also provides a source of metabolic water).	Water	159-164	arginine vasopressin	Homo sapiens	48-59
27548771-2	2016	TK-1 was designed to have hydrophilic cyclodextrin molecules and, thus, for higher water solubility and smaller particle sizes than the plasma protein-bound ICG.	Water	83-88	thymidine kinase 1	Rattus norvegicus	0-4
27548771-5	2016	These optical experiments demonstrated that TK-1 has high water solubility, a low self-aggregation tendency, and high optical and chemical stabilities.	Water	58-63	thymidine kinase 1	Rattus norvegicus	44-48
27600972-2	2016	The objective of the present study was to examine the ability of water soluble extracts (WSE) obtained from traditional Greek yoghurt made from bovine or ovine milk to modulate the expression of u-PA, u-PAR, PAI-1 and PAI-2 in ovine monocytes and neutrophils.	Water	65-70	plasminogen activator inhibitor 2	Bos taurus	218-223
28920357-6	2016	From nature, flavor and channel tropism points of view, the largest proportion of Dai medicines were cool, bitter-tasted and possesses water element.	Water	135-140	Z-DNA binding protein 1	Homo sapiens	82-85
27268273-5	2016	Comparing these to a complex with the LPA product (ATX-LPA) and with a complex with a phosphate ion (ATX-PO4), that represent the Michaelis complex of the reaction, we observe movements of Thr209, changes in the relative displacement of the zinc ions, and a water molecule that likely fulfils the second nucleophilic attack.	Water	258-263	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	51-54
27268273-5	2016	Comparing these to a complex with the LPA product (ATX-LPA) and with a complex with a phosphate ion (ATX-PO4), that represent the Michaelis complex of the reaction, we observe movements of Thr209, changes in the relative displacement of the zinc ions, and a water molecule that likely fulfils the second nucleophilic attack.	Water	258-263	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	101-104
26892488-2	2016	Hypothyroidism was induced in young-adult rats by the administration of 6-n-propyl-2-thiouracil (PTU) in tap water for 21 days.	Water	109-114	nuclear RNA export factor 1	Rattus norvegicus	105-108
27232900-13	2016	Taking into consideration that prolactin-induced protein can be associated with disruption in water transport in lacrimal glands, our findings may indicate that changes to aqueous secretion are associated with contact lens discomfort.	Water	94-99	prolactin induced protein	Homo sapiens	31-56
27102809-5	2016	Mean NO3 (-) isotopes in lysimeter water differed from soil extractions by up to 19 % in delta(18)O and 12 % in delta(15)N, indicating distinct biogeochemical processing in relatively mobile water versus soil microsites.	Water	35-40	NBL1, DAN family BMP antagonist	Homo sapiens	5-8
27341101-5	2016	The water content controlled the appearance and intensity of the Raman band at ~1787 cm(-1) when lysozyme powders were thermally denatured at temperatures higher than Tm.	Water	4-9	lysozyme	Homo sapiens	97-105
27347731-0	2016	Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.	Water	129-134	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-78
27356513-1	2016	The novel [Ru(Acriphos)(PPh3 )(Cl)(PhCO2 )] [1; Acriphos=4,5-bis(diphenylphosphino)acridine] is an excellent precatalyst for the hydrogenation of CO2 to give formic acid in dimethyl sulfoxide (DMSO) and DMSO/H2 O without the need for amine bases as co-reagents.	Water	208-212	caveolin 1	Homo sapiens	24-28
27475393-4	2016	We derive a novel exchange term and validate this method on the structural properties of SPC/E water and dialanine (Ala2) in the bulk and in the presence of a graphene layer.	Water	95-100	proline rich protein gene cluster	Homo sapiens	89-92
26985581-3	2016	A benchtop photolithographic setup is used to fabricate high fidelity and high resolution PEDOT: PSS microstructures over a large (cm) area using only water as the solvent.	Water	151-156	PSS	Homo sapiens	97-100
27397622-6	2016	The latter result is consistent with the recent observation of this reversal phenomenon in SPC/E water and points the existence of this general physical phenomenon in water.	Water	97-102	proline rich protein gene cluster	Homo sapiens	91-94
27397622-6	2016	The latter result is consistent with the recent observation of this reversal phenomenon in SPC/E water and points the existence of this general physical phenomenon in water.	Water	167-172	proline rich protein gene cluster	Homo sapiens	91-94
27340905-0	2016	Peroxisome Proliferator-Activated Receptor gamma is a Sensitive Target for Oil Sands Process-Affected Water: Effects on Adipogenesis and Identification of Ligands.	Water	102-107	peroxisome proliferator activated receptor gamma	Homo sapiens	0-48
27281682-3	2016	In order to better understand the oligomerization process of the C-terminal Abeta fragment Abeta(29-42) at the atomic level, we performed the Hamiltonian replica-permutation molecular dynamics simulation with Abeta(29-42) molecules using the explicit water solvent model.	Water	251-256	amyloid beta precursor protein	Homo sapiens	76-81
27130561-5	2016	Such a procedure is illustrated here, for the reduction of nitric oxide (NO) to nitrous oxide and water in the membrane enzyme, cytochrome c dependent nitric oxide reductase (cNOR).	Water	98-103	cytochrome c, somatic	Homo sapiens	128-140
27383386-7	2016	Overexpression of MnSOD also increased the expression of aquaporin-1 (AQP1), a water and oxygen channel.	Water	79-84	superoxide dismutase 2, mitochondrial	Mus musculus	18-23
27409610-4	2016	We analyzed the function of aquaporin 1 (AQP1), a water channel known to promote metastasis and neoangiogenes.	Water	50-55	aquaporin 1 (Colton blood group)	Homo sapiens	28-39
27409610-4	2016	We analyzed the function of aquaporin 1 (AQP1), a water channel known to promote metastasis and neoangiogenes.	Water	50-55	aquaporin 1 (Colton blood group)	Homo sapiens	41-45
27409611-1	2016	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel responsible for regulating water reabsorption through the apical plasma membrane of the principal cells of renal collecting ducts.	Water	46-51	arginine vasopressin	Homo sapiens	24-35
27409611-1	2016	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel responsible for regulating water reabsorption through the apical plasma membrane of the principal cells of renal collecting ducts.	Water	87-92	arginine vasopressin	Homo sapiens	24-35
27173896-6	2016	It was found that the fenestrations in Kv1.2 and Kir3.2 remain closed to the passage of molecules larger than water.	Water	110-115	potassium voltage-gated channel subfamily A member 2	Homo sapiens	39-44
28090219-5	2016	Released AVP molecules are eluted with purified water and transferred to a separate microchamber, and deposited onto a single spot on a MALDI plate via repeated, piezoelectrically actuated ejection, which enriches AVP molecules over the spot area.	Water	48-53	arginine vasopressin	Homo sapiens	9-12
27491574-10	2016	ALS subjects consumed a higher amount of beverages such as water, juice, milk, coffee, sport drink, beer, wine and distilled drinks than the other PA groups.	Water	59-64	superoxide dismutase 1	Homo sapiens	0-3
27491577-6	2016	RESULTS: We found an inverse association between the consumption of water (ml)/kg per weight with BMI, body fat, fat-free mass, waist circumference, insulin levels, HOMA-IR (p &lt; 0.001), and with arterial pressure parameters, systolic (p &lt; 0.010) and diastolic blood pressure (p &lt; 0.028), and mean arterial pressure (p &lt; 0.012), as well as direct associations with HDL cholesterol (p &lt; 0.001).	Water	68-73	insulin	Homo sapiens	149-156
27491577-10	2016	CONCLUSIONS: Higher consumption of water (ml)/kg per weight was negatively associated with BMI, body fat, fat-free mass, waist circumference, insulin levels, HOMA-IR, and positively with HDL cholesterol in children independently of age, sex and cardiorespiratory fi tness.	Water	35-40	insulin	Homo sapiens	142-149
27224887-2	2016	Cytotoxicity of TDP-43 may be inferred from the observation that the membrane pores catalyze lipid flip-flop between bilayer leaflets and conduct water at high rates.	Water	146-151	TAR DNA binding protein	Homo sapiens	16-22
27173896-6	2016	It was found that the fenestrations in Kv1.2 and Kir3.2 remain closed to the passage of molecules larger than water.	Water	110-115	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	49-55
27301436-5	2016	X-ray analysis of and revealed that presents a dinuclear structure whereas is trinuclear; in both cases a six-coordinated Co(II) compound with water molecules bridging each of the two Co(II) centres has been observed.	Water	143-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
27301436-5	2016	X-ray analysis of and revealed that presents a dinuclear structure whereas is trinuclear; in both cases a six-coordinated Co(II) compound with water molecules bridging each of the two Co(II) centres has been observed.	Water	143-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
27301436-6	2016	The magnetic properties of and show a weak antiferromagnetic behaviour, respectively, between the Co(II) centres mediated by two carboxylate ligands and a molecule of water.	Water	167-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
27122368-5	2016	E2 decreases expression of the angiotensin II type 1 receptor (AT1R), a receptor with known relevance to water and salt intakes, in multiple areas of the brain where ERalpha and ERbeta are differentially expressed.	Water	105-110	angiotensin II receptor, type 1b	Rattus norvegicus	31-61
27053647-5	2016	Recurrent heat-induced dehydration with ad libitum water repletion resulted in plasma and urinary hyperosmolarity with stimulation of the vasopressin (copeptin) levels and resulted in mild tubular injury and renal oxidative stress.	Water	51-56	arginine vasopressin	Rattus norvegicus	138-149
27124709-0	2016	Synthesis and Kinetic Characterisation of Water-Soluble Fluorogenic Acyl Donors for Transglutaminase 2.	Water	42-47	transglutaminase 2	Homo sapiens	84-102
27124709-3	2016	The excellent water solubility of the compounds enabled their extensive kinetic characterisation in the context of TGase 2-catalysed hydrolysis and aminolysis.	Water	14-19	transglutaminase 2	Homo sapiens	115-122
27028215-3	2016	Mass spectrometry studies suggest that in bulk water, addition of glutathione (GSH) to cytochrome c-capped Au-NCs results in the formation of glutathione-capped Au-NCs and free apo-cytochrome c.	Water	47-52	cytochrome c, somatic	Homo sapiens	87-99
26875949-3	2016	In the absence of indigo carmine, we have used 10% dextrose in sterile water (D10) as cystoscopic fluid to evaluate ureteral patency.	Water	71-76	CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion	Homo sapiens	78-81
27130953-4	2016	F56 peptide-conjugated paclitaxel-loaded nanoparticles (F56-PTX-NP) were formulated from PEGylated polylactide using an oil in water emulsion approach.	Water	127-132	DLEC1 cilia and flagella associated protein	Homo sapiens	0-3
27261598-10	2016	Cardiac membrane vesicles expressing AQP1 presented a high water permeability coefficient and pretreatment with SNP decreased water transport.	Water	59-64	aquaporin 1 (Colton blood group)	Homo sapiens	37-41
27261598-11	2016	Age-related influence of NO system on AQP1 abundance and localization in the heart may affect cardiac water homeostasis during hypovolemic state.	Water	102-107	aquaporin 1 (Colton blood group)	Homo sapiens	38-42
27261598-12	2016	Increased AQP1 S-nitrosylation in the youngest group may decrease osmotic water permeability of cardiac membranes, having a negative impact on cardiac water balance.	Water	74-79	aquaporin 1 (Colton blood group)	Homo sapiens	10-14
27122368-5	2016	E2 decreases expression of the angiotensin II type 1 receptor (AT1R), a receptor with known relevance to water and salt intakes, in multiple areas of the brain where ERalpha and ERbeta are differentially expressed.	Water	105-110	angiotensin II receptor, type 1b	Rattus norvegicus	63-67
26966862-10	2016	Altogether, the data suggest that expression of hAQP1 increases the water permeability of acinar cells, which underlies the recovery of fluid secretion in the salivary glands functionally compromised post IR.	Water	68-73	aquaporin 1 (Colton blood group)	Homo sapiens	48-53
27094275-0	2016	Removal of As(III) and As(V) from water by chitosan and chitosan derivatives: a review.	Water	34-39	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-28
27013260-7	2016	The results showed that both F10 fraction and water extract were not toxic to human cells, and they were able to stimulate the nitrite production, with values of 13.6 and 5.4 muM, respectively, suggesting that their biological activity could be due to macrophages activation via NO production.	Water	46-51	latexin	Homo sapiens	175-178
26309154-0	2016	Biophysical and molecular docking insight into interaction mechanism and thermal stability of human serum albumin isoforms with a semi-synthetic water-soluble camptothecin analog irinotecan hydrochloride.	Water	145-150	albumin	Homo sapiens	100-113
30035925-11	2016	Adding PAC(180 mesh) at a dosage of 15 mg L-1 into source water with the concentration of styrene was 0.02 mg L-1, which is the limited value in sanitary standard for drinking water, the concentration could be reduced to 0.001 mg L-1 and the removal rate of styrene was as high as 95.5% .	Water	58-63	immunoglobulin kappa variable 1-16	Homo sapiens	42-45
30035925-11	2016	Adding PAC(180 mesh) at a dosage of 15 mg L-1 into source water with the concentration of styrene was 0.02 mg L-1, which is the limited value in sanitary standard for drinking water, the concentration could be reduced to 0.001 mg L-1 and the removal rate of styrene was as high as 95.5% .	Water	58-63	immunoglobulin kappa variable 1-16	Homo sapiens	110-113
30035925-11	2016	Adding PAC(180 mesh) at a dosage of 15 mg L-1 into source water with the concentration of styrene was 0.02 mg L-1, which is the limited value in sanitary standard for drinking water, the concentration could be reduced to 0.001 mg L-1 and the removal rate of styrene was as high as 95.5% .	Water	58-63	immunoglobulin kappa variable 1-16	Homo sapiens	110-113
27093965-9	2016	In addition, there was a positive correlation between Imp-R and age, ratio of extracellular water to total body water and high-sensitive C-reactive protein.	Water	92-97	C-reactive protein	Homo sapiens	137-155
26309154-1	2016	In the present work, we have examined the binding parameters, thermodynamics, and stability of human serum albumin (HSA) isoforms at pH 7.4 and 9.0, using spectroscopic, calorimetric, and molecular docking methods in the presence of water-soluble camptothecin analog irinotecan hydrochloride (CPT-11).	Water	233-238	albumin	Homo sapiens	101-114
27290629-8	2016	In addition, the coencapsulation of both THA and Gen, which have very different water solubility, accelerated the release profile of the less water-soluble drug.	Water	80-85	GEN1 Holliday junction 5' flap endonuclease	Homo sapiens	49-52
26849413-12	2016	In vivo metformin (100 mg/Kg) in drinking water for 60 days induced Abcd2 levels and mitochondrial oxidative phosphorylation protein levels in the brain and spinal cord of Abcd1-KO mice.	Water	42-47	ATP-binding cassette, sub-family D (ALD), member 2	Mus musculus	68-73
27290629-8	2016	In addition, the coencapsulation of both THA and Gen, which have very different water solubility, accelerated the release profile of the less water-soluble drug.	Water	142-147	GEN1 Holliday junction 5' flap endonuclease	Homo sapiens	49-52
26827626-4	2016	Magnocellular vasopressin is known to be one of the main physiological regulators of water-electrolyte balance.	Water	85-90	arginine vasopressin	Homo sapiens	14-25
27138166-1	2016	Aquaporin-3 (AQP3) is an integral membrane protein that facilitates the transport of water and glycerol across cell membranes.	Water	85-90	aquaporin 3	Mus musculus	0-11
27138166-1	2016	Aquaporin-3 (AQP3) is an integral membrane protein that facilitates the transport of water and glycerol across cell membranes.	Water	85-90	aquaporin 3	Mus musculus	13-17
27350190-10	2016	These findings suggest that water deprivation may elevate the renal full-length (P)RR levels via reducing the expression of furin.	Water	28-33	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	124-129
27154707-10	2016	The developed method was successfully applied to the determination of Pb(II) in drinking water, tap water and surface water near electronic waste storage and the results were compared with those by graphite furnace atomic absorption spectroscopy (GF-AAS) with good agreement.	Water	89-94	submaxillary gland androgen regulated protein 3B	Homo sapiens	70-76
27154707-10	2016	The developed method was successfully applied to the determination of Pb(II) in drinking water, tap water and surface water near electronic waste storage and the results were compared with those by graphite furnace atomic absorption spectroscopy (GF-AAS) with good agreement.	Water	100-105	submaxillary gland androgen regulated protein 3B	Homo sapiens	70-76
27154707-10	2016	The developed method was successfully applied to the determination of Pb(II) in drinking water, tap water and surface water near electronic waste storage and the results were compared with those by graphite furnace atomic absorption spectroscopy (GF-AAS) with good agreement.	Water	100-105	submaxillary gland androgen regulated protein 3B	Homo sapiens	70-76
29903326-5	2016	RESULTS: Water quality parameters were higher in tap water and natural mineral water than in pure water.	Water	53-58	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	49-52
29903326-6	2016	On the first day of place navigation test, the escape latency of tap water group [( 69.	Water	69-74	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	65-68
29903326-14	2016	In the probe trial, the swimming time of the targeted quadrant was significantly longer in tap water group [( 28.	Water	95-100	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	91-94
29903326-22	2016	In passive avoidance test, the training latency and testing latency were significantly longer in tap water group [( 60.	Water	101-106	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	97-100
29903326-35	2016	05), as the frequency of electric shock and the percentage of animals showing errors in tap water group [( 0.	Water	92-97	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	88-91
29903326-57	2016	CONCLUSION: Compared with pure water, long-term drinking tap water or mineral water is more beneficial to learning and memory of mice, and it may be associated with a higher content of hippocampal Ach.	Water	61-66	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	57-60
29903326-57	2016	CONCLUSION: Compared with pure water, long-term drinking tap water or mineral water is more beneficial to learning and memory of mice, and it may be associated with a higher content of hippocampal Ach.	Water	61-66	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	57-60
27154707-1	2016	A simple and cost effectiveness procedure based on a paper based analytical device (PAD) for sampling, on-site preconcentration and determination of Pb(II) in water samples was developed.	Water	159-164	submaxillary gland androgen regulated protein 3B	Homo sapiens	149-155
27154707-5	2016	Water sample was loaded onto a circular filter paper coated with zirconium silicate in 3% sodium carboxymethylcellulose for Pb(II) preconcentration.	Water	0-5	submaxillary gland androgen regulated protein 3B	Homo sapiens	124-130
27362705-10	2016	Our findings in this pilot study suggest that interventions to decrease vasopressin secretion by abundant water intake, tympanic ventilation tubes and sleeping in darkness is feasible in treating Meniere"s disease, even though these therapies did not alter reported mental/physical stress levels.	Water	106-111	arginine vasopressin	Homo sapiens	72-83
27356469-6	2016	Intriguingly, both colonic enemas and drinking water with CPZ led to profound systemic hypoalgesia in WT and TRPV1(-/-) but not TRPA1(-/-) mice.	Water	47-52	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	109-114
27462134-1	2016	Aquaporin-4 (AQP4) is a selective water channel that is located on the plasma membrane of myofibers in skeletal muscle and is bound to alpha1-syntrophin.	Water	34-39	syntrophin alpha 1	Homo sapiens	135-152
27462134-6	2016	The present study suggests that AQP4 may regulate the efficiency of water transport in hypertrophied myofibers through its interaction with alpha1-syntrophin.	Water	68-73	syntrophin alpha 1	Homo sapiens	140-157
27083794-2	2016	Therefore, we developed water insoluble films based on palmitoyl esters of HA (pHA).	Water	24-29	lamin B receptor	Homo sapiens	79-82
27446930-1	2016	Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial methylmalonyl-CoA mutase (MCM).	Water	54-59	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
27446930-1	2016	Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial methylmalonyl-CoA mutase (MCM).	Water	54-59	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	29-32
27167594-1	2016	Under H2 pressure, Co(II)(dmgBF2)2L2 (L = H2O, THF) generates a low concentration of an H  donor.	Water	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-36
27251465-0	2016	Cooperative catalysis by bovine serum albumin-iodine towards cascade oxidative coupling-C(sp(2))-H sulfenylation of indoles/hydroxyaryls with thiophenols on water.	Water	157-162	albumin	Homo sapiens	32-45
27194365-6	2016	Finally we show that aging the films in water leads to loss of PSS chains which makes the films more hydrophobic.	Water	40-45	PSS	Homo sapiens	63-66
27181872-4	2016	Here, we investigate the specificity of subcritical water with respect to the production of peptides from three model proteins, hemoglobin, bovine serum albumin, and beta-casein, and compare the results with enzymatic digestion of proteins by trypsin.	Water	52-57	albumin	Homo sapiens	147-160
27334175-0	2016	Self-diffusion of protons in H2O ice VII at high pressures: Anomaly around 10 GPa.	Water	29-32	glycophorin A (MNS blood group)	Homo sapiens	78-81
26972385-1	2016	UNLABELLED: Aquaporin-8 (AQP8) allows the bidirectional transport of water and hydrogen peroxide across biological membranes.	Water	69-74	aquaporin 8	Homo sapiens	12-23
27323911-5	2016	The body weights of ob/ob mice gradually increased during vehicle treatment, but remained unchanged in response to repeated intranasal administration of GALP, with both ob/ob and diet-induced obese mice displaying significantly decreased food intake, water intake and locomotor activity when treated with GALP.	Water	251-256	galanin-like peptide	Mus musculus	153-157
26972385-1	2016	UNLABELLED: Aquaporin-8 (AQP8) allows the bidirectional transport of water and hydrogen peroxide across biological membranes.	Water	69-74	aquaporin 8	Homo sapiens	25-29
26972385-5	2016	RESULTS: We show that diverse cellular stress conditions, including heat, hypoxia, and ER stress, reversibly inhibit the permeability of AQP8 to H2O2 and water.	Water	154-159	aquaporin 8	Homo sapiens	137-141
27123778-4	2016	Thus, heating a mixture of 2 and H2 O@2 with hydrogen cyanide and formaldehyde in chlorobenzene affords HCN@2 and H2 CO@2, respectively.	Water	33-37	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	104-109
26914374-6	2016	As a result of the interaction between GABARAP and CRT, the clustering of the functionalized MNPs generates local magnetic fields, which accelerate the dephasing of the water protons in the vicinity.	Water	169-174	calreticulin	Homo sapiens	51-54
26992899-10	2016	Taken together, our results suggest that Nrf2-dependent antioxidant response was involved in the resistance of preneoplastic cells upon exposure to fecal water of hemoglobin- and beef-fed rats.	Water	154-159	NFE2 like bZIP transcription factor 2	Rattus norvegicus	41-45
26971208-3	2016	The In Situ Sampler (IS2) is an automated submersible device capable of extracting dissolved contaminants from water (100s-1000smL) over extended periods (hours to weeks), retaining the analytes, and rejecting the processed fluid.	Water	111-116	IS2	Homo sapiens	21-24
28955897-3	2016	Dramatic differences in the (7-aza)Trp-Baa and (2,7-aza)Trp-Baa fluorescence properties between free peptide in water and calmodulin-bound peptide were observed, showing a less polar and water scant environment at the binding interface of the peptide upon calmodulin binding.	Water	187-192	calmodulin 1	Homo sapiens	122-132
28955897-3	2016	Dramatic differences in the (7-aza)Trp-Baa and (2,7-aza)Trp-Baa fluorescence properties between free peptide in water and calmodulin-bound peptide were observed, showing a less polar and water scant environment at the binding interface of the peptide upon calmodulin binding.	Water	187-192	calmodulin 1	Homo sapiens	256-266
26994932-3	2016	The hydrolytic activity of NKA is found to depend on membrane phase, and the water relaxation in the membrane on the presence of NKA.	Water	77-82	tachykinin precursor 1	Homo sapiens	27-30
26994932-3	2016	The hydrolytic activity of NKA is found to depend on membrane phase, and the water relaxation in the membrane on the presence of NKA.	Water	77-82	tachykinin precursor 1	Homo sapiens	129-132
27210595-1	2016	We report on the synthesis and characterization of a novel manganese vanadate, Mn1.5(H2O)(NH4)V4O12, with rare in situ disorder of Mn(H2O)2(2+)/2NH4(+).	Water	85-88	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	79-82
27210595-1	2016	We report on the synthesis and characterization of a novel manganese vanadate, Mn1.5(H2O)(NH4)V4O12, with rare in situ disorder of Mn(H2O)2(2+)/2NH4(+).	Water	134-137	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	79-82
27212397-2	2016	Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) ( PEDOT: PSS) dispersion in water is a widely used commercial conducting polymer for the fabrication of electron devices.	Water	84-89	PSS	Homo sapiens	65-68
27219867-0	2016	Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.	Water	16-21	bromodomain containing 4	Homo sapiens	59-63
27219867-0	2016	Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.	Water	16-21	CECR2 histone acetyl-lysine reader	Homo sapiens	84-89
26826591-7	2016	When O(2) leaves the active site, a second Ca-bound water molecule reorients to bridge the gap between the manganese ions Mn1 and Mn4, forming a new oxo-bridge for the next reaction cycle.	Water	52-57	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	122-125
26992899-0	2016	Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats.	Water	136-141	NFE2 like bZIP transcription factor 2	Rattus norvegicus	32-36
26992899-8	2016	Fecal water activated Nrf2 in both cell lines, associated with the induction of Nrf2-target genes related to aldehydes detoxification.	Water	6-11	NFE2 like bZIP transcription factor 2	Rattus norvegicus	22-26
26992899-8	2016	Fecal water activated Nrf2 in both cell lines, associated with the induction of Nrf2-target genes related to aldehydes detoxification.	Water	6-11	NFE2 like bZIP transcription factor 2	Rattus norvegicus	80-84
26896895-4	2016	Furthermore, the bioaccumulation factor (BAF) of total MCs, MC-LR and MC-RR in the vegetable after irrigation with contaminated water was determined.	Water	128-133	BAF nuclear assembly factor 1	Homo sapiens	17-39
27037930-3	2016	AVP increases solute-free water retention by acting on the V2 receptors of the kidney-collecting tubes.	Water	26-31	arginine vasopressin	Homo sapiens	0-3
26896895-4	2016	Furthermore, the bioaccumulation factor (BAF) of total MCs, MC-LR and MC-RR in the vegetable after irrigation with contaminated water was determined.	Water	128-133	BAF nuclear assembly factor 1	Homo sapiens	41-44
26248901-6	2016	The study has been complemented by a two-bottle free-choice assay between tap water and sweetened drinks.	Water	78-83	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	74-77
27131751-3	2016	We examined the effects of maternal rat ingestion of Pb in drinking water during gestation and lactation on the expression of SIRT1 and CREB in the hippocampus of their offspring at postnatal week 3 (PNW3) and 52 (PNW52), and then reexamined these effects in offspring after intragastric administration of resveratrol for 4 weeks.	Water	68-73	sirtuin 1	Rattus norvegicus	126-131
27100344-5	2016	We report the synthesis of water soluble nanosize conjugates of paclitaxel, branched PEG, and EGFR-targeting peptide by employing native chemical ligation.	Water	27-32	epidermal growth factor receptor	Homo sapiens	94-98
27383327-8	2016	Water-solvable vitamin E Trolox significantly promoted MCF7 cell proliferation in vitro, while reducing intracellular ROS level and p53 expression.	Water	0-5	tumor protein p53	Homo sapiens	132-135
26610908-3	2016	Tolvaptan, an antagonist of vasopressin type 2 receptor, inhibits water reabsorption in cirrhosis.	Water	66-71	arginine vasopressin	Homo sapiens	28-39
26073357-6	2016	The addition of H2 O and articaine modulated the gene expression of Casp3 or Hist3H3.	Water	16-20	caspase 3	Homo sapiens	68-73
26073357-6	2016	The addition of H2 O and articaine modulated the gene expression of Casp3 or Hist3H3.	Water	16-20	H3.4 histone	Homo sapiens	77-84
27060822-14	2016	This study indicated that a small amount of iron contamination in bovine drinking water at the farm or incidental iron addition from potable water sources causes oxidation, affects milk protein composition and stability, and affects final milk quality.	Water	82-87	Weaning weight-maternal milk	Bos taurus	181-185
27060822-14	2016	This study indicated that a small amount of iron contamination in bovine drinking water at the farm or incidental iron addition from potable water sources causes oxidation, affects milk protein composition and stability, and affects final milk quality.	Water	82-87	Weaning weight-maternal milk	Bos taurus	239-243
27060822-14	2016	This study indicated that a small amount of iron contamination in bovine drinking water at the farm or incidental iron addition from potable water sources causes oxidation, affects milk protein composition and stability, and affects final milk quality.	Water	141-146	Weaning weight-maternal milk	Bos taurus	181-185
27060822-14	2016	This study indicated that a small amount of iron contamination in bovine drinking water at the farm or incidental iron addition from potable water sources causes oxidation, affects milk protein composition and stability, and affects final milk quality.	Water	141-146	Weaning weight-maternal milk	Bos taurus	239-243
27258268-5	2016	Immunostaining showed that AQP11 was localized at the epithelium of the choroid plexus and at the endothelium of the brain capillary, suggesting that AQP11 may be involved in water transport at the choroid plexus and blood-brain barrier (BBB) in the brain.	Water	175-180	aquaporin 11	Mus musculus	27-32
27258268-5	2016	Immunostaining showed that AQP11 was localized at the epithelium of the choroid plexus and at the endothelium of the brain capillary, suggesting that AQP11 may be involved in water transport at the choroid plexus and blood-brain barrier (BBB) in the brain.	Water	175-180	aquaporin 11	Mus musculus	150-155
26984615-6	2016	We demonstrate that, at low SDS concentrations, the N-terminus of A beta participates in the solubilization, most likely by being located at the particle-water interface.	Water	154-159	amyloid beta precursor protein	Homo sapiens	66-72
27060822-0	2016	Milk protein composition and stability changes affected by iron in water sources.	Water	67-72	Weaning weight-maternal milk	Bos taurus	0-4
27060822-1	2016	Water makes up more than 80% of the total weight of milk.	Water	0-5	Weaning weight-maternal milk	Bos taurus	52-56
27060822-2	2016	However, the influence of water chemistry on the milk proteome has not been extensively studied.	Water	26-31	Weaning weight-maternal milk	Bos taurus	49-53
27068863-6	2016	Adaptive VP secretion can modulate membrane ion transport, water permeability, and blood-brain barrier integrity, which are largely via changing astrocytic plasticity.	Water	59-64	arginine vasopressin	Homo sapiens	9-11
26901626-3	2016	In this report, a photo-active Mn(II) complex of boradiazaindacene derivatives (Mn1) was used as a dioxygen generator under irradiation with LED light in water.	Water	154-159	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	80-83
27068863-7	2016	Maladaptive VP hypersecretion leads to disruptions of ion and water balance across cell membranes as well as the integrity of the blood-brain barrier.	Water	62-67	arginine vasopressin	Homo sapiens	12-14
27126699-3	2016	KEY FINDINGS: It was revealed that the heat threshold of the tail measured by an increasing-temperature water bath is significantly higher in TRPV1(-/-), but not TRPA1(-/-), mice compared to respective wild-types.	Water	104-109	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	142-147
27536693-9	2016	This happens when a person drinks a significant amount of water while exercising in the setting of antidiuretic hormone production from prolonged exercise.	Water	58-63	arginine vasopressin	Homo sapiens	99-119
26681180-0	2016	Fat ViP MRI: Virtual Phantom Magnetic Resonance Imaging of water-fat systems.	Water	59-64	vasoactive intestinal peptide	Homo sapiens	4-7
26681180-2	2016	The aim of this study was to assess the feasibility of ViP MRI to generate complex-data images of phantoms mimicking water-fat systems.	Water	117-122	vasoactive intestinal peptide	Homo sapiens	55-58
26681180-10	2016	CONCLUSION: The ViP MRI method allows for generating imaging phantoms that i) mimic water-fat systems and ii) can be analyzed with water-fat separation algorithms based on complex data.	Water	84-89	vasoactive intestinal peptide	Homo sapiens	16-19
26681180-10	2016	CONCLUSION: The ViP MRI method allows for generating imaging phantoms that i) mimic water-fat systems and ii) can be analyzed with water-fat separation algorithms based on complex data.	Water	131-136	vasoactive intestinal peptide	Homo sapiens	16-19
27193313-0	2016	Salt effects on the picosecond dynamics of lysozyme hydration water investigated by terahertz time-domain spectroscopy and an insight into the Hofmeister series for protein stability and solubility.	Water	62-67	lysozyme	Homo sapiens	43-51
26993802-0	2016	Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1.	Water	65-70	aquaporin 1 (Colton blood group)	Homo sapiens	79-90
26993802-1	2016	The aquaporin-1 (AQP1) water channel is a potentially important drug target, as AQP1 inhibition is predicted to have therapeutic action in edema, tumor growth, glaucoma, and other conditions.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	4-15
26993802-1	2016	The aquaporin-1 (AQP1) water channel is a potentially important drug target, as AQP1 inhibition is predicted to have therapeutic action in edema, tumor growth, glaucoma, and other conditions.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	17-21
26993802-1	2016	The aquaporin-1 (AQP1) water channel is a potentially important drug target, as AQP1 inhibition is predicted to have therapeutic action in edema, tumor growth, glaucoma, and other conditions.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	80-84
26993802-4	2016	As a positive control, 0.3 mM HgCl2 inhibited AQP1 water permeability by &gt;95%.	Water	51-56	aquaporin 1 (Colton blood group)	Homo sapiens	46-50
26563124-10	2016	Visual GSx/Cr correlated with brain water content in the thalamus, nucleus caudatus, and visual cortex (P &lt; 0.01).	Water	36-41	ATP binding cassette subfamily C member 1	Homo sapiens	7-10
27193313-2	2016	We investigated the effects of Hofmeister salts on the picosecond dynamics of water around a lysozyme molecule using terahertz time-domain spectroscopy.	Water	78-83	lysozyme	Homo sapiens	93-101
27193313-4	2016	From the difference in the salt concentration dependence for various salts, it has been found that chaotropic anions make the dynamics of water around the lysozyme molecule slower, whereas kosmotropic anions make the dynamics faster.	Water	138-143	lysozyme	Homo sapiens	155-163
27193313-6	2016	This result indicates that the effects of anions on the dynamics of water around the lysozyme molecule are the opposite of those for bulk water.	Water	68-73	lysozyme	Homo sapiens	85-93
26945740-7	2016	AtPNP-A also causes cGMP-dependent net water uptake into WT protoplasts, and hence volume increases, whereas responses of the protoplasts from the receptor mutant are impaired.	Water	39-44	plant natriuretic peptide A	Arabidopsis thaliana	0-7
26945740-8	2016	Taken together, our results suggest that the identified LRR protein is an AtPNP-A receptor essential for the PNP-dependent regulation of ion and water homeostasis in plants and that PNP- and vertebrate NP-receptors and their signaling mechanisms share surprising similarities.	Water	145-150	plant natriuretic peptide A	Arabidopsis thaliana	74-81
27193313-6	2016	This result indicates that the effects of anions on the dynamics of water around the lysozyme molecule are the opposite of those for bulk water.	Water	138-143	lysozyme	Homo sapiens	85-93
27222936-3	2016	In this study, the structural changes in water due to the presence of ions are investigated by molecular dynamics simulations of various monatomic ions in the SPC/E water model.	Water	41-46	proline rich protein gene cluster	Homo sapiens	159-162
27222936-3	2016	In this study, the structural changes in water due to the presence of ions are investigated by molecular dynamics simulations of various monatomic ions in the SPC/E water model.	Water	165-170	proline rich protein gene cluster	Homo sapiens	159-162
26950622-3	2016	In this study, C18 solid phase extraction coupled with electrospray ionization ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) was used to characterize unknown I-DBPs in chloraminated/chlorinated water spiked with iodide and humic substances.	Water	245-250	Bardet-Biedl syndrome 9	Homo sapiens	15-18
27020623-1	2016	The expression of six different aquaporins (AQP1, 2, 3, 4, 5 and 9), integral membrane water channels that facilitate bi-directional passive movement of water, was investigated by immunohistochemistry in the uterine tube of pre-pubertal and adult Saanen goats (Capra hircus), comparing the different phases of the oestrous cycle.	Water	87-92	aquaporin-1	Capra hircus	44-66
27020623-1	2016	The expression of six different aquaporins (AQP1, 2, 3, 4, 5 and 9), integral membrane water channels that facilitate bi-directional passive movement of water, was investigated by immunohistochemistry in the uterine tube of pre-pubertal and adult Saanen goats (Capra hircus), comparing the different phases of the oestrous cycle.	Water	153-158	aquaporin-1	Capra hircus	44-66
27240625-3	2016	Deep water formation that connects the two limbs of the AMOC results in a high downward export of non-refractory DOC (197 Tg-C yr(-1)).	Water	5-10	transglutaminase 2	Homo sapiens	122-126
27038586-2	2016	Because of the impossibility of measuring the concentration and evaluating the toxicity of each individual halogenated DBP in a water sample, total organic halogen (TOX) as a collective parameter and a toxicity indicator for all the halogenated DBPs has been gaining popularity in recent years.	Water	128-133	D-box binding PAR bZIP transcription factor	Homo sapiens	119-122
25415872-1	2016	This study was designed to evaluate the protective effect of water extract of Amaranthus lividus L. (A. lividus) (Amaranthaceae) on carbon tetrachloride (CCl4)-induced toxicity in kidneys of rats.	Water	61-66	C-C motif chemokine ligand 4	Rattus norvegicus	154-158
27126610-0	2016	Electronic Structure Theory Study of the Microsolvated F(-)(H2O) + CH3I SN2 Reaction.	Water	60-63	solute carrier family 38 member 5	Homo sapiens	72-75
27126610-3	2016	The water molecule remains on the fluorine side until the reactive system goes to the SN2 saddle point.	Water	4-9	solute carrier family 38 member 5	Homo sapiens	86-89
27098963-4	2016	Because consistent data sets for partitioning of IOCs are rarely available, bovine serum albumin-water partition coefficients (KBSA/w) were measured in this study for 45 anionic and 4 cationic organic chemicals, including various substituted benzoic and naphthoic acids, sulfonates and several pesticides and pharmaceuticals.	Water	97-102	albumin	Homo sapiens	83-96
27083257-6	2016	The affinity for C18/SCX-SPME for tested organic cations without Hbond capacities increased with longer alkyl chains, ranging from logarithmic fiber-water distribution coefficients (log Dfw) of 1.8 (benzylamine) to 5.8 (triflupromazine).	Water	149-154	Bardet-Biedl syndrome 9	Homo sapiens	17-20
27222637-0	2016	Erratum to: Interleukin-1beta-induced reduction of tissue water diffusion in the juvenile rat brain on ADC MRI is not associated with (31)P MRS-detectable energy failure.	Water	58-63	interleukin 1 beta	Rattus norvegicus	12-29
27213818-2	2016	Aim of this study was to determine the molecular effect of Acmella oleracea extract and its main alkylamide spilanthol on two major processes involved in the urine concentrating mechanism: Na-K-2Cl symporter (NKCC2) activity in the thick ascending limb and water channel aquaporin 2 accumulation at the apical plasma membrane of collecting duct cells.	Water	257-262	solute carrier family 12, member 1	Mus musculus	209-214
27196718-2	2016	* This observance highlights ways that swimmers; parents of young swimmers; aquatic facility operators; residential pool, hot tub, or spa owners; beach managers; and public health officials can maximize the health benefits of water-based physical activity while minimizing the risk for recreational water-associated illness and injury.	Water	226-231	TUB bipartite transcription factor	Homo sapiens	126-129
27196718-2	2016	* This observance highlights ways that swimmers; parents of young swimmers; aquatic facility operators; residential pool, hot tub, or spa owners; beach managers; and public health officials can maximize the health benefits of water-based physical activity while minimizing the risk for recreational water-associated illness and injury.	Water	299-304	TUB bipartite transcription factor	Homo sapiens	126-129
27098963-8	2016	Hence, alternative modeling strategies will be required for accurate prediction of serum albumin-water partition coefficients of organic ions.	Water	97-102	albumin	Homo sapiens	83-96
27506012-6	2016	The sequence of mass concentrations of water-soluble ions was: SO42- &gt; NO3- &gt; NH4+ &gt; Cl- &gt; K+ &gt; Na+, while the mass concentrations of SO42-, NO3-, NH4+, which were the main ion components, exceeded 10 microg   m-3.	Water	39-44	NBL1, DAN family BMP antagonist	Homo sapiens	74-77
27506012-6	2016	The sequence of mass concentrations of water-soluble ions was: SO42- &gt; NO3- &gt; NH4+ &gt; Cl- &gt; K+ &gt; Na+, while the mass concentrations of SO42-, NO3-, NH4+, which were the main ion components, exceeded 10 microg   m-3.	Water	39-44	NBL1, DAN family BMP antagonist	Homo sapiens	156-159
26951941-4	2016	We showed that the inhibitory effect of E2 on ANGII-induced water and sodium intake requires the ERK1/2 and JNK signaling pathways.	Water	60-65	angiotensinogen	Rattus norvegicus	46-51
27229103-1	2016	Aquaporin 1(AQP1) and AQP5 have an important role in eliminating extravascular lung water, an increase of which contributes to lung injury in patients with sepsis and its consequent mortality.	Water	84-89	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
27229103-1	2016	Aquaporin 1(AQP1) and AQP5 have an important role in eliminating extravascular lung water, an increase of which contributes to lung injury in patients with sepsis and its consequent mortality.	Water	84-89	aquaporin 1 (Colton blood group)	Homo sapiens	12-16
27109895-0	2016	Dynamics of human acetylcholinesterase bound to non-covalent and covalent inhibitors shedding light on changes to the water network structure.	Water	118-123	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
27179490-1	2016	We investigate pressure driven flow rates of water through a (6,6) carbon nanotube (CNT) for the TIP3P, SPC/E, and TIP4P/2005 water models.	Water	45-50	proline rich protein gene cluster	Homo sapiens	104-107
26951941-8	2016	Taken together, these results demonstrate that E2 modulates ANGII-induced water and sodium intake and AVP secretion by affecting the ERK1/2 and JNK pathways in the lamina terminalis and ERK1/2 signaling in the hypothalamic nuclei (PVN and SON) in OVX rats.	Water	74-79	angiotensinogen	Rattus norvegicus	60-65
27089954-7	2016	The constructed free energy diagram from the reactants to the products suggests that the enzyme regeneration, but not the nucleophilic attack of the catalytic water molecule, corresponds to the rate-determining stage of the full catalytic cycle of ASPA.	Water	159-164	aspartoacylase	Homo sapiens	248-252
27079442-1	2016	In this work, novel water-soluble carbon nanocrystals (CNCs) with excellent fluorescence were prepared, and successfully applied to sensitive fluorescence detection of thrombin by using an enzyme-assisted autocatalytic DNA recycling amplification strategy.	Water	20-25	coagulation factor II, thrombin	Homo sapiens	168-176
27153052-1	2016	AQP0 water channels are the most abundant proteins expressed in the mammalian lens fiber membranes where they are essential for lens development and transparency.	Water	5-10	major intrinsic protein of lens fiber	Homo sapiens	0-4
27165276-2	2016	Aquaporin-3 (AQP3) is a small transmembrane water/glycerol channel that may facilitate the membrane uptake of hydrogen peroxide (H2O2).	Water	44-49	aquaporin 3	Mus musculus	0-11
27165276-2	2016	Aquaporin-3 (AQP3) is a small transmembrane water/glycerol channel that may facilitate the membrane uptake of hydrogen peroxide (H2O2).	Water	44-49	aquaporin 3	Mus musculus	13-17
27153052-2	2016	Unlike other aquaporin paralogs, mammalian AQP0 has a low intrinsic water permeability, but can form cell-to-cell junctions between the lens fibers.	Water	68-73	major intrinsic protein of lens fiber	Homo sapiens	43-47
27011264-5	2016	The slow reaction process on the single Co(III) -OH site of the Co3 O4 cocatalyst, oxidizing H2 O to H2 O2 with two photogenerated holes, could be accelerated by the timely H2 O2 oxidation to O2 catalyzed on CDots.	Water	93-97	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	40-47
26878290-0	2016	Dielectric spectroscopy study of water dynamics in frozen bovine milk.	Water	33-38	Weaning weight-maternal milk	Bos taurus	65-69
27147445-2	2016	Imbibing seeds to a water content of 45% or greater prior to PEF treatment increased the glutathione level and activities of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and ascorbate peroxidase in the resultant seedlings, compared to untreated controls.	Water	20-25	catalase	Homo sapiens	147-155
26685080-3	2016	Selective inhibition of the AQP1 water channel may provide a new approach for the treatment of several disorders including ocular hypertension/glaucoma, congestive heart failure, brain swelling associated with a stroke, corneal and macular edema, pulmonary edema, and otic disorders such as hearing loss and vertigo.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	28-32
26685080-6	2016	These selected compounds directly inhibited water transport in AQP1-enriched stripped erythrocyte ghosts and in proteoliposomes reconstituted with purified AQP1.	Water	44-49	aquaporin 1 (Colton blood group)	Homo sapiens	63-67
26685080-6	2016	These selected compounds directly inhibited water transport in AQP1-enriched stripped erythrocyte ghosts and in proteoliposomes reconstituted with purified AQP1.	Water	44-49	aquaporin 1 (Colton blood group)	Homo sapiens	156-160
27417718-1	2016	With the use of surface plasmon resonance (SPR) it was shown that ws-Lynx1, a water-soluble analog of the three-finger membrane-bound protein Lynx1, that modulates the activity of brain nicotinic acetylcholine receptors (nAChRs), interacts with the acetylcholine-binding protein (AChBP) with high affinity, K D = 62 nM.	Water	78-83	Ly6/neurotoxin 1	Homo sapiens	69-74
27417718-1	2016	With the use of surface plasmon resonance (SPR) it was shown that ws-Lynx1, a water-soluble analog of the three-finger membrane-bound protein Lynx1, that modulates the activity of brain nicotinic acetylcholine receptors (nAChRs), interacts with the acetylcholine-binding protein (AChBP) with high affinity, K D = 62 nM.	Water	78-83	Ly6/neurotoxin 1	Homo sapiens	142-147
27264560-1	2016	Aquaporin 8 (Aqp8) is a transmembrane protein that is selectively permeated by water and some small solutes, and physiologically contributes to acid-base equilibrium in the gastrointestinal tract.	Water	79-84	aquaporin 8a, tandem duplicate 1	Danio rerio	0-11
27264560-1	2016	Aquaporin 8 (Aqp8) is a transmembrane protein that is selectively permeated by water and some small solutes, and physiologically contributes to acid-base equilibrium in the gastrointestinal tract.	Water	79-84	aquaporin 8a, tandem duplicate 1	Danio rerio	13-17
26741353-3	2016	Glucocorticoid signalling dysfunction and endoplasmic reticulum (ER) and oxidative stresses strongly contribute to IR and associate with MS. We have described that natural mineral-rich water ingestion delays fructose-induced MS development, modulates fructose effects on the redox state and glucocorticoid signalling and increases sirtuin 1 expression.	Water	185-190	sirtuin 1	Rattus norvegicus	331-340
27437269-4	2016	AIM: We aimed to study association of use of RO processed water for drinking with Vitamin B12 deficiency.	Water	58-63	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	90-93
27437269-11	2016	Although association of male gender, milk quantity of less than 100 ml per day and duration of RO water intake with occurrence of Vitamin B12 deficiency was found statistically significant in univariate analysis, logistic regression analysis did not show significant association.	Water	98-103	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	138-141
26497277-3	2016	The identification of a water-filled pore that is mainly constituted by Pex5 and Pex14 led to the assumption that proteins are translocated through a large, probably transient, protein-conducting channel.	Water	24-29	peroxisomal biogenesis factor 14	Homo sapiens	81-86
26340797-10	2016	CONCLUSIONS: To our knowledge, this is the largest DBP and fetal growth study to date with individual water use data, and the first to examine individual-level estimates of joint THM-HAA exposure.	Water	102-107	D-box binding PAR bZIP transcription factor	Homo sapiens	51-54
26878290-7	2016	In addition, the first process, attributed to water-lactose complexes, obeys the Meyer-Neldel compensation law and can be taken as evidence of differing interfaces of these complexes with the bulk water of the milk, mediated by the lactose concentration.	Water	46-51	Weaning weight-maternal milk	Bos taurus	210-214
26878290-7	2016	In addition, the first process, attributed to water-lactose complexes, obeys the Meyer-Neldel compensation law and can be taken as evidence of differing interfaces of these complexes with the bulk water of the milk, mediated by the lactose concentration.	Water	197-202	Weaning weight-maternal milk	Bos taurus	210-214
26878290-9	2016	Considering the mentioned above, we conclude that our results emphasize the structural and dynamical significance of water in bovine milk.	Water	117-122	Weaning weight-maternal milk	Bos taurus	133-137
26991533-2	2016	CLC-K chloride channels and their accessory subunit barttin play a pivotal role in kidney by controlling chloride and water absorption.	Water	118-123	cardiotrophin-like cytokine factor 1	Rattus norvegicus	0-3
27095837-8	2016	Transport assays in oocytes showed NIP4;1 and NIP4;2 function as water and nonionic channels.	Water	65-70	NOD26-like intrinsic protein 4;2	Arabidopsis thaliana	46-52
26234923-6	2016	These three (especially GC-SPI) had higher water-binding than SPI (8.2-12.6 versus 6.2 g g(-1) protein).	Water	43-48	chromogranin A	Homo sapiens	27-30
27095837-9	2016	We also found that NIP4;1 and NIP4;2 C termini are phosphorylated by a pollen-specific CPK that modifies their water permeability.	Water	111-116	NOD26-like intrinsic protein 4;2	Arabidopsis thaliana	30-36
26945065-0	2016	The Sodium Glucose Cotransporter SGLT1 Is an Extremely Efficient Facilitator of Passive Water Transport.	Water	88-93	solute carrier family 5 member 1	Canis lupus familiaris	33-38
26996808-8	2016	We also revealed one new KEL*02M allele with p.Gly263Glu in contact with solvent (water) located within the second lobe of the ectodomain.	Water	82-87	Kell metallo-endopeptidase (Kell blood group)	Homo sapiens	25-28
26945065-2	2016	Implications of the sodium glucose cotransporter SGLT1 in either pumping water or passively channeling water contrast with its reported water transporting capacity, which lags behind that of aquaporin-1 by 3 orders of magnitude.	Water	73-78	solute carrier family 5 member 1	Canis lupus familiaris	49-54
26945065-2	2016	Implications of the sodium glucose cotransporter SGLT1 in either pumping water or passively channeling water contrast with its reported water transporting capacity, which lags behind that of aquaporin-1 by 3 orders of magnitude.	Water	103-108	solute carrier family 5 member 1	Canis lupus familiaris	49-54
26945065-2	2016	Implications of the sodium glucose cotransporter SGLT1 in either pumping water or passively channeling water contrast with its reported water transporting capacity, which lags behind that of aquaporin-1 by 3 orders of magnitude.	Water	103-108	solute carrier family 5 member 1	Canis lupus familiaris	49-54
26945065-8	2016	Although the similarity between the pf values of SGLT1 and aquaporin-1 makes a transcellular pathway plausible, it renders water pumping physiologically negligible because the passive flux would be orders of magnitude larger.	Water	123-128	solute carrier family 5 member 1	Canis lupus familiaris	49-54
27065476-1	2016	The collection of water from fog is a simple and sustainable means of obtaining freshwater for human and animal consumption.	Water	18-23	zinc finger protein, FOG family member 1	Homo sapiens	29-32
28891611-3	2016	The results showed that the IC50 concentration values of water extract, water extract from alcohol precipitation, alcohol extract, and alcohol and water extract were 0.801 4, 0.859 1, 0.796 1, 0.918 0 g L-1; and the alcohol extract is the best method to extract antioxidative components, with the highest antioxidant activity and lowest IC50.	Water	57-62	immunoglobulin kappa variable 1-16	Homo sapiens	203-206
28891611-3	2016	The results showed that the IC50 concentration values of water extract, water extract from alcohol precipitation, alcohol extract, and alcohol and water extract were 0.801 4, 0.859 1, 0.796 1, 0.918 0 g L-1; and the alcohol extract is the best method to extract antioxidative components, with the highest antioxidant activity and lowest IC50.	Water	72-77	immunoglobulin kappa variable 1-16	Homo sapiens	203-206
28891611-3	2016	The results showed that the IC50 concentration values of water extract, water extract from alcohol precipitation, alcohol extract, and alcohol and water extract were 0.801 4, 0.859 1, 0.796 1, 0.918 0 g L-1; and the alcohol extract is the best method to extract antioxidative components, with the highest antioxidant activity and lowest IC50.	Water	72-77	immunoglobulin kappa variable 1-16	Homo sapiens	203-206
32263341-3	2016	In the water solutions with denaturants such as urea and guanidinium, the disulfide-crosslinked albumin hydrogels showed a normal swelling profile.	Water	7-12	albumin	Homo sapiens	96-103
27119634-2	2016	We report here the characterization of water dynamics on the L-asparaginase structural homology isozymes L-asparaginases I (AnsA) and II (AnsB), which are shown via fluorescence spectroscopy and dynamics in combination with molecular dynamics simulation to have distinct catalytic activity.	Water	39-44	asparaginase and isoaspartyl peptidase 1	Homo sapiens	61-75
27097089-4	2016	The results of total abundance of microphytobenthos varied from 4.2 x 108 to 2.9 x 109 organisms L-1, total density increased one order of magnitude under the effect of water for both situations of precipitation in the salt flat and in experimental conditions, an increase due to the high abundance of Microcoleus spp.	Water	169-174	immunoglobulin kappa variable 1-16	Homo sapiens	97-100
26719364-5	2016	TGF-beta1 also increases urinary excretion of water, electrolytes and glucose by suppressing tubular reabsorption in both normal and diabetic conditions.	Water	46-51	transforming growth factor beta 1	Homo sapiens	0-9
27143883-2	2016	However, the poor water solubility of 734THIF impedes its absorption and skin penetration and, therefore, limits its pharmacological effects when applied topically to the skin.	Water	18-23	thioredoxin interacting protein	Homo sapiens	41-45
27060105-6	2016	Relative to the water-soluble Nrf2, less attention has hitherto been drawn to the membrane-bound Nrf1, even though it has been shown to be indispensable for embryonic development and organ integrity.	Water	16-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
27016434-4	2016	In-situ SbSPCE-CNF was successfully used for the simultaneous determination of Pb(II) and Cd(II) ions, by means of differential pulse anodic stripping voltammetry, in a certified reference estuarine water sample with a very high reproducibility and good trueness.	Water	199-204	submaxillary gland androgen regulated protein 3B	Homo sapiens	79-96
27548955-4	2016	The total dissolved solid (TDS) in the river water ranged from 24.9 to 50.3 mg   L-1.	Water	45-50	immunoglobulin kappa variable 1-16	Homo sapiens	81-84
26983558-1	2016	Crystallization of ice from deeply supercooled water and amorphous ices - a process of fundamental importance in the atmosphere, interstellar space, and cryobiology - results in stacking disordered ices with a wide range of metastabilities with respect to hexagonal ice.	Water	47-52	carboxylesterase 2	Homo sapiens	19-22
26871556-0	2016	Characteristics of extended-spectrum beta-lactamase (ESBL)- and pAmpC beta-lactamase-producing Enterobacteriaceae of water samples in Tunisia.	Water	117-122	EsbL	Escherichia coli	19-51
26871556-1	2016	The presence of extended-spectrum beta-lactamase and plasmid-mediated AmpC beta-lactamase producing Enterobacteriaceae (ESBL-Eb and pAmpC-Eb, respectively) was analyzed in 57 wastewater and 57 surface-water samples in Tunisia.	Water	180-185	EsbL	Escherichia coli	16-48
26983558-3	2016	Here we use molecular dynamics simulations with the mW water model to characterize the structure of ice freshly grown from supercooled water at temperatures from 210 to 270 K, the thermodynamics of stacking faults, line defects, and interfaces, and to elucidate the interplay between kinetics and thermodynamics in determining the structure of ice.	Water	135-140	carboxylesterase 2	Homo sapiens	100-103
26983558-7	2016	The free energy cost for creating a pair of cubic layers in ice is 8.0 J mol(-1) in experiments, and 9.7 +- 1.9 J mol(-1) for the mW water model.	Water	133-138	carboxylesterase 2	Homo sapiens	60-63
30052009-0	2016	[Spectroscopic Studies on the Interaction of Human Serum Albumin and Water-Soluble Carboxyl Carbon Nanotubes].	Water	69-74	albumin	Homo sapiens	51-64
26867575-1	2016	Cystathionine beta-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the condensation of homocysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, respectively.	Water	186-191	cystathionine beta-synthase	Homo sapiens	0-27
26782327-1	2016	Dissolved trace elements and heavy metals in the Dan River drainage basin, which is the drinking water source area of South-to-North Water Transfer Project (China), affect large numbers of people and should therefore be carefully monitored.	Water	97-102	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
26782327-1	2016	Dissolved trace elements and heavy metals in the Dan River drainage basin, which is the drinking water source area of South-to-North Water Transfer Project (China), affect large numbers of people and should therefore be carefully monitored.	Water	133-138	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
26782327-6	2016	According to the water quality index, water in the Dan River drainage was suitable for drinking; however, an exposure risk assessment model suggests that As and Sb in the Laojun and Laoguan rivers could pose a high risk to humans in terms of adverse health and potential non-carcinogenic effects.	Water	38-43	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
29931961-5	2016	RESULTS: (1)Compared with those in the Sham group, W/D and total lung water content (TLW) in other groups increased significantly (P&lt;0.05), the mRNA and protein expression levels of TLR4 in lung tissues increased too.	Water	70-75	toll-like receptor 4	Rattus norvegicus	185-189
26774643-2	2016	Increasing evidence suggests that the key factor leading to impaired neuronal function is accumulation of water-soluble Abeta oligomers rather than formation of the senile plaques created by the deposition of large fibrillary aggregates of Abeta.	Water	106-111	amyloid beta precursor protein	Homo sapiens	120-125
26614453-0	2016	PCDD/F and PCB water column partitioning examination using natural organic matter and black carbon partition coefficient models.	Water	15-20	pyruvate carboxylase	Homo sapiens	11-14
30052009-2	2016	In this paper, the fluorescence spectroscopy, synchronous fluorescence spectroscopy and circular dichroism spectroscopy) were used to analyze the interaction between four water-soluble carboxyl carbon nanotubes (long-SWCNTs-COOH, short-SWCNTs-COOH, DWCNTs-COOH and MWCNTs-COOH) and human serum albumin.	Water	171-176	albumin	Homo sapiens	288-301
30052009-3	2016	Results showed that the four water-soluble carboxylated carbon nanotubes could quench the intrinsic fluorescence of human serum albumin at different extents.	Water	29-34	albumin	Homo sapiens	122-135
30052009-6	2016	The four water-soluble carboxyl carbon nanotubes could cause slight changes of the CD spectra of human serum albumin as well as the alpha-helix and beta-sheet contents of human serum albumin.	Water	9-14	albumin	Homo sapiens	103-116
30052009-6	2016	The four water-soluble carboxyl carbon nanotubes could cause slight changes of the CD spectra of human serum albumin as well as the alpha-helix and beta-sheet contents of human serum albumin.	Water	9-14	albumin	Homo sapiens	177-190
27090718-3	2016	Peptides are thought to be an important category of DBP precursors in water.	Water	70-75	D-box binding PAR bZIP transcription factor	Homo sapiens	52-55
26432370-2	2016	Here, we developed a novel magnetic composite bio-adsorbent, graphene oxide and magnetic chitosan-ionic liquids (GOMCS-ILs), for removing Pb(II) from water.	Water	150-155	submaxillary gland androgen regulated protein 3B	Homo sapiens	138-144
26432370-10	2016	These results demonstrated the potential applications of GOMCS-ILs microspheres in efficient removal of Pb(II) from wastewater and deep-purification of polluted water.	Water	121-126	submaxillary gland androgen regulated protein 3B	Homo sapiens	104-110
26405833-5	2016	In contrast, B/C mats formed at locations where oxygen in the water column was comparatively abundant (&gt;45 muM) and continuously present.	Water	62-67	latexin	Homo sapiens	110-113
26924063-2	2016	On the other hand, free-water transport takes place through aquaporin-1 channels, but leads to sodium retention and over hydration.	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	60-71
26912321-7	2016	Taken together, our studies revealed a novel function of the HVEM cosignaling molecule and its ligands in EAU pathogenesis through the induction of Th1- and Th17-type T cell responses and suggested that HVEM-related molecular pathways can be therapeutic targets in autoimmune uveitis.	Water	106-109	negative elongation factor complex member C/D, Th1l	Mus musculus	148-151
26921309-10	2016	Mincle activation was sufficient to generate the EAU phenotype, and this required activation of both Syk and Card9.	Water	49-52	C-type lectin domain family 4 member E	Homo sapiens	0-6
26791475-1	2016	The present study aimed to investigate the potential physiological role of vasopressin and the incretin hormone of the gastrointestinal tract (glucagon-like peptide-1; GLP-1) in the regulation of the water-salt balance in a hyperosmolar state as a result of sodium loadings.	Water	200-205	arginine vasopressin	Rattus norvegicus	75-86
27105403-6	2016	Coagulation was shown to significantly reduce the cytotoxicity of the water, indicating that removal of natural organic matter DBP precursors continues to be an important factor in drinking water treatment.	Water	70-75	D-box binding PAR bZIP transcription factor	Homo sapiens	127-130
27105403-6	2016	Coagulation was shown to significantly reduce the cytotoxicity of the water, indicating that removal of natural organic matter DBP precursors continues to be an important factor in drinking water treatment.	Water	190-195	D-box binding PAR bZIP transcription factor	Homo sapiens	127-130
26828284-2	2016	Complex 1, [Cu(PyBIm)(NO3)(H2O)](NO3), is a four coordinate, distorted square planar species with one ligand (N,N), nitrate and water bound to Cu(II).	Water	27-31	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
26828284-2	2016	Complex 1, [Cu(PyBIm)(NO3)(H2O)](NO3), is a four coordinate, distorted square planar species with one ligand (N,N), nitrate and water bound to Cu(II).	Water	27-31	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
26828284-2	2016	Complex 1, [Cu(PyBIm)(NO3)(H2O)](NO3), is a four coordinate, distorted square planar species with one ligand (N,N), nitrate and water bound to Cu(II).	Water	128-133	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
26828284-2	2016	Complex 1, [Cu(PyBIm)(NO3)(H2O)](NO3), is a four coordinate, distorted square planar species with one ligand (N,N), nitrate and water bound to Cu(II).	Water	128-133	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
26882290-1	2016	The binding mode of water soluble peripherally tetra-substituted titanium(IV) phthalocyanine (Pc) compounds Pc1, Pc2 and Pc3 with calf thymus (CT) DNA was investigated by using UV-Vis spectroscopy and thermal denaturation studies in this work.	Water	20-25	proprotein convertase subtilisin/kexin type 1	Bos taurus	108-111
26882290-1	2016	The binding mode of water soluble peripherally tetra-substituted titanium(IV) phthalocyanine (Pc) compounds Pc1, Pc2 and Pc3 with calf thymus (CT) DNA was investigated by using UV-Vis spectroscopy and thermal denaturation studies in this work.	Water	20-25	proprotein convertase subtilisin/kexin type 2	Bos taurus	113-116
26882290-1	2016	The binding mode of water soluble peripherally tetra-substituted titanium(IV) phthalocyanine (Pc) compounds Pc1, Pc2 and Pc3 with calf thymus (CT) DNA was investigated by using UV-Vis spectroscopy and thermal denaturation studies in this work.	Water	20-25	proprotein convertase subtilisin/kexin type 1	Bos taurus	121-124
26645545-6	2016	Acetone and diethylether followed by water induced persistent upregulation of Tlr4 mRNA and increased TLR4 expression in GFAP-expressing astrocytes in spinal cord dorsal horn.	Water	37-42	toll-like receptor 4	Mus musculus	78-82
26976055-3	2016	It also depends on the influence of antidiuretic hormone on the permeability to water of the collecting ducts on their entire length, and on the permeability to urea limited to the terminal portion of these ducts in the inner medulla.	Water	80-85	arginine vasopressin	Homo sapiens	36-56
26645545-6	2016	Acetone and diethylether followed by water induced persistent upregulation of Tlr4 mRNA and increased TLR4 expression in GFAP-expressing astrocytes in spinal cord dorsal horn.	Water	37-42	toll-like receptor 4	Mus musculus	102-106
27209700-1	2016	One water-soluble polysaccharide (ASPS), with four molecular weight distributions of 74, 3.8, 4.5, 2.3 x 10(4) Da, was isolated from the root of Acanthopanax senticosus and the yield was 4.8% (w/w).	Water	4-9	casein kinase 1 delta	Homo sapiens	34-38
26913482-5	2016	Here, we report yet another crystal structure of the truncated hemoglobin from Arabidopsis thaliana (AHb3) with two water molecules in the heme pocket, of which one is distinctly coordinated to the heme iron, unlike the only available crystal structure of AHb3 with a hydroxyl ligand.	Water	116-121	hemoglobin 2	Arabidopsis thaliana	63-73
26864343-1	2016	Removals of Pb(II) and Zn(II) ions from water using crab (Clistocoeloma sinensis) shell particles as biosorbent have been compared in this study.	Water	40-45	submaxillary gland androgen regulated protein 3B	Homo sapiens	12-29
26950406-3	2016	In this study, replica exchange molecular dynamics simulations have been performed to elucidate for the first time the molecular mechanism of adsorption and subsequent unfolding of hen egg white lysozyme at low pH at a polarized 1,2-dichloroethane/water interface.	Water	248-253	lysozyme	Homo sapiens	195-203
26950406-6	2016	By contrast, as expected, lysozyme in neat water at low pH does not exhibit significant structural changes.	Water	43-48	lysozyme	Homo sapiens	26-34
26838407-4	2016	The accuracy of the method was assessed by the spiking-and-recovery experiments for particular water samples and the recoveries found, being in range from 99% to 105% for As(III) and from 104% to 106% for As(V), respectively, were quantitative.	Water	95-100	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	205-210
26667399-3	2016	The detection limit was calculated to be 7.1 x 10(-9) M, which is much lower than the maximum permissable concentration in drinking water (1.9 muM) set by the World Health Organization (WHO).	Water	132-137	latexin	Homo sapiens	143-146
27026206-7	2016	CUMS induced elevation in IL-1beta protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water.	Water	162-167	interleukin 1 beta	Mus musculus	26-34
27026206-9	2016	Our data suggest that the beneficial effects of hydrogen-rich water on depressive-like behavior may be mediated by suppression of the inflammasome activation resulting in attenuated protein IL-1beta and ROS production.	Water	62-67	interleukin 1 beta	Mus musculus	190-198
27064357-2	2016	Tile-drained, agricultural watersheds experience high seasonal inputs of NO3-N, but low phosphorus (PO4-P) and dissolved organic carbon (DOC) loads relative to surface water dominated systems.	Water	27-32	NBL1, DAN family BMP antagonist	Homo sapiens	73-76
26931298-5	2016	The molecular structure of this water-soluble urethane polymer and its host-guest complexes with PNP were investigated using spectroscopic (Raman, (1)H NMR, induced circular dichroism), dynamic light scattering (DLS), and calorimetric (DSC) methods in aqueous solution at ambient pH, and compared with native beta-CD.	Water	32-37	purine nucleoside phosphorylase	Homo sapiens	97-100
26739651-0	2016	Adropin acts in brain to inhibit water drinking: potential interaction with the orphan G protein-coupled receptor, GPR19.	Water	33-38	G protein-coupled receptor 19	Rattus norvegicus	115-120
27003523-5	2016	An increased ADH secretion results in an impaired ability to excrete free water.	Water	74-79	arginine vasopressin	Homo sapiens	13-16
26989349-0	2016	Interleukin-1beta-induced reduction of tissue water diffusion in the juvenile rat brain on ADC MRI is not associated with (31)P MRS-detectable energy failure.	Water	46-51	interleukin 1 beta	Rattus norvegicus	0-17
26989349-1	2016	BACKGROUND: It has long been known that an intrastriatal microinjection of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1beta), in juvenile rats induces a chronic reduction in the apparent diffusion coefficient (ADC) of tissue water on magnetic resonance imaging (MRI).	Water	246-251	interleukin 1 beta	Rattus norvegicus	117-134
26989349-1	2016	BACKGROUND: It has long been known that an intrastriatal microinjection of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1beta), in juvenile rats induces a chronic reduction in the apparent diffusion coefficient (ADC) of tissue water on magnetic resonance imaging (MRI).	Water	246-251	interleukin 1 beta	Rattus norvegicus	136-144
26739651-3	2016	Reduction in GPR19 mRNA levels in medial basal hypothalamus of male rats resulted in the loss of the inhibitory effect of adropin on water deprivation-induced thirst.	Water	133-138	G protein-coupled receptor 19	Rattus norvegicus	13-18
26949978-7	2016	Mechanistic investigations of dioxygen reduction revealed that the reaction proceeds through a eta(2)-peroxo intermediate (Int1) at low temperatures followed by subsequent ligand oxidation at higher temperatures in a reaction that consumed half an equivalent of O2 and produced water as a final oxygenic byproduct.	Water	278-283	Wnt family member 1	Homo sapiens	123-127
26575717-0	2016	Effect of water and gluten on physico-chemical properties and stability of ready to eat shelf-stable pasta.	Water	10-15	solute carrier family 45 member 1	Homo sapiens	101-106
26575717-4	2016	Higher amounts of water and gluten reduced pasta hardening and contributed to control RTE pasta quality.	Water	18-23	solute carrier family 45 member 1	Homo sapiens	43-48
26575717-4	2016	Higher amounts of water and gluten reduced pasta hardening and contributed to control RTE pasta quality.	Water	18-23	solute carrier family 45 member 1	Homo sapiens	90-95
26859842-4	2016	The addition of a nitrifying biofilm sample collected from a nitrifying facility to its non-nitrifying influent water led to increases in N-nitrosamine and halogenated DBP formation, suggesting the release of precursors from nitrifying biofilms.	Water	112-117	D-box binding PAR bZIP transcription factor	Homo sapiens	168-171
26777227-2	2016	In this study, we describe the successful demonstration of the water- and temperature-triggered reversible structural transformation between cubane- and planar-type tetranuclear Co(II) cores sandwiched by polyoxometalates.	Water	63-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
26795303-5	2016	This performance is considered satisfactory because the EF process took place under rather unfavorable conditions, such as neutral pH, low dissolved O2 concentration, low electrical conductivity, and presence of natural organic matter and inorganic ions in tap water.	Water	261-266	SEC14 like lipid binding 2	Homo sapiens	257-260
26974824-8	2016	Moreover, increased expression of interleukin-1beta and downstream phosphorylated-p38-mitogen-activated protein kinase were concordant with apoptosis induction in the placentas of salt water-treated wild-type mice.	Water	185-190	interleukin 1 beta	Mus musculus	34-51
26920783-3	2016	Tb-CIP/AMP emits strong green luminescence due to the inclusion of AMP, which withdraws the coordinated water molecules and shields Tb(3+) from the quenching effect of O-H vibration in water molecules.	Water	104-109	adenine phosphoribosyltransferase	Homo sapiens	0-10
26920783-3	2016	Tb-CIP/AMP emits strong green luminescence due to the inclusion of AMP, which withdraws the coordinated water molecules and shields Tb(3+) from the quenching effect of O-H vibration in water molecules.	Water	185-190	adenine phosphoribosyltransferase	Homo sapiens	0-10
26898857-1	2016	We study the orientation of water and urea molecules and protein amide vibrations at aqueous alpha-lactalbumin and alpha-lactalbumin/urea interfaces using heterodyne-detected vibrational sum frequency generation.	Water	28-33	lactalbumin alpha	Homo sapiens	115-132
26968975-14	2016	CONCLUSIONS: Preexisting systemic inflammation plus a short severe hypoxia elicits cerebral edema through upregulated AQP4 and water permeability by TLR4 and CRH/CRHR1 signaling.	Water	127-132	toll-like receptor 4	Rattus norvegicus	149-153
26964638-6	2016	High water storage capacity 1727.5 cm(3) g(-1) (138.9 wt.%) has been found for as-synthesized GIS-NaP1 zeolite microsphere samples during water vapour adsorption studies.	Water	5-10	nucleosome assembly protein 1 like 1	Homo sapiens	98-102
26968975-14	2016	CONCLUSIONS: Preexisting systemic inflammation plus a short severe hypoxia elicits cerebral edema through upregulated AQP4 and water permeability by TLR4 and CRH/CRHR1 signaling.	Water	127-132	corticotropin releasing hormone	Rattus norvegicus	158-161
26880377-7	2016	While continuous water wires are frequently observed in the presence of physiologically transported Cl-, binding of F- or NO3- leads to the formation of pseudo-water-wires that are substantially different from the wires formed with Cl-.	Water	160-165	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
26741914-3	2016	The Hy1 is a highly stable hydrate, which dissociates above 135  C and loses only a small part of the water when stored over desiccants (25  C) for more than one year.	Water	102-107	RNA, Ro60-associated Y1	Homo sapiens	4-7
26840181-1	2016	Numerous studies have identified the presence and bioactivity of glucocorticoid receptor (GR) active substances in water; however, the identification and activity-balance of GR compounds remained elusive.	Water	115-120	nuclear receptor subfamily 3 group C member 1	Homo sapiens	65-88
26840181-1	2016	Numerous studies have identified the presence and bioactivity of glucocorticoid receptor (GR) active substances in water; however, the identification and activity-balance of GR compounds remained elusive.	Water	115-120	nuclear receptor subfamily 3 group C member 1	Homo sapiens	90-92
26757403-0	2016	Fluorescent Detection of 2,4-DNT and 2,4,6-TNT in Aqueous Media by Using Simple Water-Soluble Pyrene Derivatives.	Water	80-85	chromosome 16 open reading frame 82	Homo sapiens	43-46
26757403-4	2016	Filter paper test strips impregnated with 1x10(-5)  m solutions of the probes were able to detect TNT, 2,4-DNT, and other NACs at levels as low as 50 ppb in water.	Water	157-162	chromosome 16 open reading frame 82	Homo sapiens	98-101
26741914-4	2016	In Hy1, orotic acid and water molecules are linked by strong hydrogen bonds in nearly perfectly planar arranged stacked layers.	Water	24-29	RNA, Ro60-associated Y1	Homo sapiens	3-6
26757403-1	2016	Pyrene-containing water-soluble probes for the fluorescent detection of nitroaromatic compounds (NACs), such as explosive components (2,4-DNT and 2,4,6-TNT) and herbicides (2,4-dinitrocresol, 2,4-DNOC), in aqueous media are reported.	Water	18-23	chromosome 16 open reading frame 82	Homo sapiens	152-155
26061483-2	2016	For the OH + CH4/CD4 hydrogen abstraction reactions, the methyl radical (CH3 and CD3) product translational distributions and the water (H2O and HOD) product vibrational distributions experimentally reported by Liu"s group are reproduced by quasi-classical trajectory (QCT) calculations on an analytical full-dimensional potential energy surface when a quantum spirit is included in the analysis.	Water	137-140	CD4 molecule	Homo sapiens	17-20
26822702-3	2016	This was validated by QM calculations giving a picture of the electronic properties of the transition state (TS) for nucleophilic attack of water on the gamma-PO3(-) group based on the structure of a RhoA/GAP-GDP-MgF3(-) TSA complex.	Water	140-145	ras homolog family member A	Homo sapiens	200-204
25388276-5	2016	Next, we showed that enhancing CREB activity through rolipram administration prior to testing improved WM performance in withdrawn mice but impaired WM function in water mice.	Water	164-169	cAMP responsive element binding protein 1	Mus musculus	31-35
26810185-7	2016	The results for water-ethanol solution and ethanol-ethyl lactate solution show that LSP, TLSP-LBFGS, and TLSP-LM can, for both absorbance prediction and concentration prediction, obtain smaller root mean square error of prediction than CLS.	Water	16-21	kallikrein related peptidase 11	Homo sapiens	89-93
26810185-7	2016	The results for water-ethanol solution and ethanol-ethyl lactate solution show that LSP, TLSP-LBFGS, and TLSP-LM can, for both absorbance prediction and concentration prediction, obtain smaller root mean square error of prediction than CLS.	Water	16-21	kallikrein related peptidase 11	Homo sapiens	105-109
27156764-1	2016	Aquaporins (AQPs) are a 13 member family (AQP0-12) of proteins that act as channels, through which water and, for some family members, glycerol, urea and other small solutes can be transported.	Water	99-104	major intrinsic protein of lens fiber	Homo sapiens	42-49
26711671-9	2016	Furthermore, HA4 treatment increased water content of SC and decreased TEWL.	Water	37-42	keratin 34	Homo sapiens	13-16
26733691-4	2016	HDA9 mutation led to up-regulation of many genes, among which those involved in response to water deprivation stress (GO: 0009414) were enriched.	Water	92-97	histone deacetylase 9	Arabidopsis thaliana	0-4
26730722-5	2016	In particular, rats treated with both mineralocorticoid and AngII preferentially worked for access to sodium versus water compared with rats given only one of these hormones.	Water	116-121	angiotensinogen	Rattus norvegicus	60-65
26705826-3	2016	In this way, the hydration functions and water factors of fibrinogen monolayers were quantitatively evaluated at various pHs.	Water	41-46	fibrinogen beta chain	Homo sapiens	58-68
26424533-0	2016	Unit cell structure of water-filled monoolein in inverted hexagonal mesophase in the presence of incorporated tricaprylin and entrapped lysozyme.	Water	23-28	lysozyme	Homo sapiens	136-144
26898981-0	2016	Adjuvant properties of water extractable arabinoxylans with different structural features from wheat flour against model antigen ovalbumin.	Water	23-28	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	129-138
26743432-9	2016	Thus AtLOS5 overexpression induced the expression of ABA biosynthetic genes to promote ABA accumulation, which activated ion transporter and PIP aquaporin gene expression to regulate root ion fluxes and water uptake, thus maintaining high cytosolic K(+) and Na(+) homeostasis and better water status in maize exposed to salt stress.	Water	203-208	molybdenum cofactor sulfurase (LOS5) (ABA3)	Arabidopsis thaliana	5-11
26638215-8	2016	Addition of progesterone decreased the inhibitory effect of E1 and E2 on the accumulation of water in the brain.	Water	93-98	carboxylesterase 1C	Rattus norvegicus	60-69
27276737-4	2016	Contamination of extended-spectrum beta-lactamase (ESBL)-producing E. coli was identified in 174 samples of foods and open water sources collected from the target communities.	Water	123-128	EsbL	Escherichia coli	17-49
26912083-9	2016	A water-soluble tetrazolium (WST-1) assay showed that both full length and truncated hEC-SOD proteins were enzymatically active.	Water	2-7	superoxide dismutase 3	Homo sapiens	85-92
26824789-2	2016	We herein examined the aggregation behavior of the physiologically relevant two types of cytochrome c, metal-bound cytochrome c, and its fragment with high amyloidogenicity as predicted in alcohol/water mixtures.	Water	197-202	cytochrome c, somatic	Homo sapiens	89-101
27006441-2	2016	At that time, AQP1 dysfunction was suggested as the cause of impaired free-water transport.	Water	75-80	aquaporin 1 (Colton blood group)	Homo sapiens	14-18
27239852-6	2016	Mitochondrion membrane potential was reduced, cytochrome released into the cytoplasm and caspase-9 and caspase-3 were significantly increased (P &lt; 0.01) after treatment with H(2)O(2).	Water	177-182	caspase 9	Rattus norvegicus	89-98
26674240-3	2016	To extend such modeling to more complex glass materials, we adopt a more comprehensive amorphous glass potential, and use a simplified approach to define the interaction between the hydroxylated surface and SPC/E water.	Water	213-218	proline rich protein gene cluster	Homo sapiens	207-210
26475849-2	2016	This dilutional phenomenon is caused by free water transport through the water channel aquaporin-1.	Water	45-50	aquaporin 1 (Colton blood group)	Homo sapiens	87-98
26475849-2	2016	This dilutional phenomenon is caused by free water transport through the water channel aquaporin-1.	Water	73-78	aquaporin 1 (Colton blood group)	Homo sapiens	87-98
26558997-4	2016	The highest efficiency is observed for relatively large micrometric particles of ThO2 which is assigned to ultrasonically-driven particle fragmentation accompanied by mechanochemical water molecule splitting.	Water	183-188	THO complex 2	Homo sapiens	81-85
26732522-3	2016	Light scattering analysis of lidocaine alone in water gave a critical aggregation concentration (CAC) of 572 muM and a mean aggregate size of 58.8 nm.	Water	48-53	latexin	Homo sapiens	109-112
26732522-5	2016	When the two drugs were mixed at their eutectic 1:1 ratio in water the CAC reduced to 165.8 muM and the aggregate size was 43.82 nm.	Water	61-66	latexin	Homo sapiens	92-95
26863188-1	2016	Although the oxidation of water is efficiently catalysed by the oxygen-evolving complex in photosystem II (refs 1 and 2), it remains one of the main bottlenecks when aiming for synthetic chemical fuel production powered by sunlight or electricity.	Water	26-31	tissue factor pathway inhibitor 2	Homo sapiens	107-119
26837049-1	2016	Aquaporin (AQP) 9, a member of the transmembrane water channel family, is defined as a water/glycerol transporting protein.	Water	49-54	aquaporin 9	Homo sapiens	0-17
26837049-1	2016	Aquaporin (AQP) 9, a member of the transmembrane water channel family, is defined as a water/glycerol transporting protein.	Water	87-92	aquaporin 9	Homo sapiens	0-17
26724910-0	2016	Sub-1 nm Nickel Molybdate Nanowires as Building Blocks of Flexible Paper and Electrochemical Catalyst for Water Oxidation.	Water	106-111	SUB1 regulator of transcription	Homo sapiens	0-5
26912239-0	2016	Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro.	Water	40-45	aquaporin 1 (Colton blood group)	Homo sapiens	28-39
26731673-1	2016	A novel interpenetrated 2D + 2D   2D architechture {[Zn(BTPS)(TPA)] 1.5DMF H2O}n () has been constructed under solvothermal conditions.	Water	75-78	plasminogen activator, tissue type	Homo sapiens	62-65
26902720-0	2016	Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.	Water	11-16	Wnt family member 3	Homo sapiens	43-46
26812884-1	2016	Aquaporin1 (AQP1) belongs to a highly conserved family of aquaporin proteins which facilitate water flux across cell membranes.	Water	94-99	aquaporin 1 (Colton blood group)	Homo sapiens	0-10
26606902-12	2016	Our present results show that these chemically synthesized water-dispersed CDs have the ability to selectively sense the bound iron from released iron of Tf without any conformational perturbation and hence they can be used as potential biological iron sensors as well as luminescent markers for the detection of iron deficiency/overload in biological macromolecules.	Water	59-64	transferrin	Homo sapiens	154-156
26812884-1	2016	Aquaporin1 (AQP1) belongs to a highly conserved family of aquaporin proteins which facilitate water flux across cell membranes.	Water	94-99	aquaporin 1 (Colton blood group)	Homo sapiens	12-16
26624532-0	2016	Surface interactions, thermodynamics and topography of binary monolayers of Insulin with dipalmitoylphosphatidylcholine and 1-palmitoyl-2-oleoylphosphatidylcholine at the air/water interface.	Water	175-180	insulin	Homo sapiens	76-83
26831376-4	2016	Structure analysis reveals the presence of NO3(-) counteranions in the intermolecular channels/pockets, which could potentially act as H-bonding sites between adsorbed water molecules within the channels.	Water	168-173	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
26843787-3	2016	In general, 1,2-amino ethanols were obtained in high yield and excellent enantiopurity by the reduction of the chiral 1,2-azido ethanols with PPh3 in water/THF, and then converted into the Boc or acetamide derivatives.	Water	150-155	caveolin 1	Homo sapiens	142-146
26966995-6	2016	Our results show that the fibronectin film in water has more distinct and stronger water cluster peaks compared to water alone.	Water	46-51	fibronectin 1	Homo sapiens	26-37
26966995-6	2016	Our results show that the fibronectin film in water has more distinct and stronger water cluster peaks compared to water alone.	Water	83-88	fibronectin 1	Homo sapiens	26-37
26966995-6	2016	Our results show that the fibronectin film in water has more distinct and stronger water cluster peaks compared to water alone.	Water	83-88	fibronectin 1	Homo sapiens	26-37
27363162-3	2016	The result showed that TN and NO3- -N contents in the soil of upstream section and higher (175 m) altitude of water level were higher than those in downstream and low (165 m) altitude of water level, whereas the pattern for NH4+ -N was different, with higher NH4+ -N contents in downstream and low water level.	Water	110-115	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
26662491-1	2016	Aquaporin 0 (AQP0) is a transmembrane protein specific to the eye lens, involved as a water carrier across the lipid membranes.	Water	86-91	major intrinsic protein of lens fiber	Homo sapiens	0-11
26803001-7	2016	The elaborated microsensor showed fast responses towards catechol additions to tap water - a weakly supported medium - characterized by a linear range from 0.2 to 10 muM, a sensitivity of 1.35 +- 0.4 A M(-1) cm(-2) and a dynamic range up to 43 muM.	Water	83-88	latexin	Homo sapiens	166-169
26803001-7	2016	The elaborated microsensor showed fast responses towards catechol additions to tap water - a weakly supported medium - characterized by a linear range from 0.2 to 10 muM, a sensitivity of 1.35 +- 0.4 A M(-1) cm(-2) and a dynamic range up to 43 muM.	Water	83-88	latexin	Homo sapiens	244-247
26757444-0	2016	A Mononuclear Co(II) Coordination Complex Locked in a Confined Space and Acting as an Electrochemical Water-Oxidation Catalyst: A "Ship-in-a-Bottle" Approach.	Water	102-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
26633853-4	2016	For example, we demonstrate the remarkable adsorption ability of Pb(II) and As(V) in waste water by the ultrathin FeOOH nanosheets.	Water	91-96	submaxillary gland androgen regulated protein 3B	Homo sapiens	65-71
26662491-1	2016	Aquaporin 0 (AQP0) is a transmembrane protein specific to the eye lens, involved as a water carrier across the lipid membranes.	Water	86-91	major intrinsic protein of lens fiber	Homo sapiens	13-17
26662491-3	2016	We investigate in this work the capability of truncated AQP0 to conduct water across membranes.	Water	72-77	major intrinsic protein of lens fiber	Homo sapiens	56-60
26662491-8	2016	We then determine the permeability of a single functional AQP0 and demonstrate that truncated AQP0 is no more a water channel.	Water	112-117	major intrinsic protein of lens fiber	Homo sapiens	94-98
26702556-7	2016	Moreover, the main driving force was identified to be the combination between the very limited solubility of 2-PCB in pure water and the hydrophobic nature of the activated carbon.	Water	123-128	pyruvate carboxylase	Homo sapiens	111-114
26839969-3	2016	A polysaccharides depleted-water extract of P. lactiflora (PL-PP) increased LIF expression in human endometrial Ishikawa cells at non-cytotoxic doses.	Water	27-32	pyridoxal (pyridoxine, vitamin B6) phosphatase	Mus musculus	59-64
26045535-8	2016	RESULTS: Ang II increased renal vascular resistance, water intake, and urine output and Na(+) excretion, decreased urine osmolality, and produced proteinuria in cPLA2alpha(+/+) mice.	Water	53-58	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	9-15
26378870-0	2016	Development of a 4-NQO toxic equivalency factor (TEF) approach to enable a preliminary risk assessment of unknown genotoxic compounds detected by the Ames II test in UV/H2O2 water treatment samples.	Water	174-179	TEF transcription factor, PAR bZIP family member	Homo sapiens	23-47
26378870-0	2016	Development of a 4-NQO toxic equivalency factor (TEF) approach to enable a preliminary risk assessment of unknown genotoxic compounds detected by the Ames II test in UV/H2O2 water treatment samples.	Water	174-179	TEF transcription factor, PAR bZIP family member	Homo sapiens	49-52
26846498-8	2016	The Co(II) cations are bridged by BDC(2-) ligands and are octahedrally coordinated by three carboxylate O atoms from three BDC(2-) ligands, one water O atom and two pyridine N atoms.	Water	144-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26495828-2	2016	Both thyroid receptor (TR) and androgen receptor (AR) agonistic/antagonistic potencies in grade II surface water in East China were investigated using reporter gene assays.	Water	107-112	androgen receptor	Homo sapiens	50-52
26646685-3	2016	Application of a chemically standardized jujube water extract in cultured RAW 264.7 cells for 24 h stimulated the expressions of HO-1, biliverdin reductase A, biliverdin reductase B, and ferroportin in a concentration-dependent manner, having the maximal responses from twofolds to threefolds.	Water	48-53	heme oxygenase 1	Mus musculus	129-133
26497650-7	2016	Aerosolized water (fog) and 200 muM capsaicin were used to induce cough.	Water	12-17	zinc finger protein, FOG family member 1	Homo sapiens	19-22
27209746-11	2016	The results of nitrate measurements by the field seawater tests in Yantai coast are obtained, which nitrate concentrations are about 0.2 mg   L-1 in seawater, and the recoveries of samples for standard recovery tests are in 95%~110%, it shows that this system is accurate, reliability and practicability and could be developed for detected nitrate concentration in natural water.	Water	52-57	immunoglobulin kappa variable 1-16	Homo sapiens	142-145
26869435-1	2016	An approach to characterizing P-glycoprotein (Pgp) interaction potential for sparingly water-soluble compounds was developed using bidirectional transport kinetics in MDR1-MDCK cell monolayers.	Water	87-92	ATP binding cassette subfamily B member 1	Homo sapiens	30-44
26869435-1	2016	An approach to characterizing P-glycoprotein (Pgp) interaction potential for sparingly water-soluble compounds was developed using bidirectional transport kinetics in MDR1-MDCK cell monolayers.	Water	87-92	ATP binding cassette subfamily B member 1	Homo sapiens	46-49
26989345-0	2016	Additive Effect on Soybean Peroxidase-Catalyzed Removal of Anilines from Water.	Water	73-78	peroxidase	Glycine max	27-37
26667411-9	2016	Cardiac corin levels were positively correlated with systolic function (r=0.96, P=0.003) and inversely with lung water (r=-0.92, P=0.001).	Water	113-118	corin, serine peptidase	Homo sapiens	8-13
26889932-2	2016	In the full-scan mass spectra obtained in the negative ion detection mode, uranium signal was featured by the uranyl nitrate complexes (e.g. [UO2 (NO3 )3 ](-) ), which yielded characteristic fragments in the tandem mass spectrometry experiments, allowing confident detection of trace uranium in water samples without sample pretreatment.	Water	295-300	NBL1, DAN family BMP antagonist	Homo sapiens	147-150
26599142-8	2016	Moreover, there were some correlations between DBPs and water quality parameters as well as between different DBP categories.	Water	56-61	D-box binding PAR bZIP transcription factor	Homo sapiens	47-50
27118886-2	2016	Water is described using the SPC/E model.	Water	0-5	proline rich protein gene cluster	Homo sapiens	29-32
26704386-3	2016	Two of our constructed 2D COF models (B1 and C3) are identified as a sufficiently efficient organocatalyst for visible light water splitting.	Water	125-130	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	38-47
26709951-4	2016	Water stabilization was achieved by binding the polyelectrolyte to two different biological systems which are currently used as nanocarriers: human serum albumin (HSA) and lipid vesicles.	Water	0-5	albumin	Homo sapiens	148-161
26475588-4	2016	The classic RAS comprises the ACE-ANG II-AT1R axis that promotes vasoconstriction; water intake; sodium retention; and increased oxidative stress, fibrosis, cellular growth, and inflammation.	Water	83-88	angiotensin I converting enzyme	Homo sapiens	30-33
26650147-3	2016	Our results show that decomposition efficiency of AVFA was limited by the availability of soluble reactive phosphorus (Pi) in the surface water (&lt;0.3 muM), as it was greatly enhanced after Pi addition to the incubation water.	Water	138-143	latexin	Homo sapiens	153-156
26650147-4	2016	In contrast, peptide decomposition rate in the subsurface water, enriched with Pi (0.4-1.2 muM), was twice as high as that in the surface water, concomitant with the development of fast-growing bacteria during the incubation.	Water	58-63	latexin	Homo sapiens	91-94
27006775-0	2016	High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP-oleic acid complex: study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution.	Water	126-131	fatty acid binding protein 3	Homo sapiens	77-83
26192010-2	2016	Previous studies have demonstrated that the administration of apolipoprotein E-mimetic peptide COG1410 reduces the brain water content after subarachnoid hemorrhage, intra-cerebral hemorrhage, and focal brain ischemia.	Water	121-126	apolipoprotein E	Mus musculus	62-78
27594763-5	2016	The use of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) was found to increase the degradation by easing water ingress into the device.	Water	126-131	PSS	Homo sapiens	73-76
26592619-11	2016	The detection limits of 1.2 and 1.6mg L(-1) for benomyl and aldicarb were obtained when the separation was performed at 120 C with flow rate of 0.4mL min(-1) water.	Water	158-163	CD59 molecule (CD59 blood group)	Homo sapiens	150-156
27403182-3	2016	Arginine-vasopressin (AVP) plays important roles in circulatory and water homeostasis, one of which is water retention through the V2 receptor.	Water	68-73	arginine vasopressin	Homo sapiens	0-20
27403182-3	2016	Arginine-vasopressin (AVP) plays important roles in circulatory and water homeostasis, one of which is water retention through the V2 receptor.	Water	68-73	arginine vasopressin	Homo sapiens	22-25
27403182-3	2016	Arginine-vasopressin (AVP) plays important roles in circulatory and water homeostasis, one of which is water retention through the V2 receptor.	Water	103-108	arginine vasopressin	Homo sapiens	0-20
27403182-3	2016	Arginine-vasopressin (AVP) plays important roles in circulatory and water homeostasis, one of which is water retention through the V2 receptor.	Water	103-108	arginine vasopressin	Homo sapiens	22-25
26760974-6	2016	During a 1-hour 3.86% mini-peritoneal equilibration test (mini-PET), AQP1fl/fl; Cdh5-Cre+ mice exhibited strongly decreased indices for AQP1-related transcellular water transport (43.0% in net ultrafiltration, 93.0% in sodium sieving and 57.9% in free water transport) compared to controls.	Water	163-168	cadherin 5	Mus musculus	80-84
26760974-6	2016	During a 1-hour 3.86% mini-peritoneal equilibration test (mini-PET), AQP1fl/fl; Cdh5-Cre+ mice exhibited strongly decreased indices for AQP1-related transcellular water transport (43.0% in net ultrafiltration, 93.0% in sodium sieving and 57.9% in free water transport) compared to controls.	Water	252-257	cadherin 5	Mus musculus	80-84
26656758-4	2016	The mRNA and protein expression level of NKCC2 significantly increased by about 40% and 90% respectively in response to restricting water intake to 1ml/day/20g for 7 days.	Water	132-137	solute carrier family 12, member 1	Mus musculus	41-46
26490534-4	2016	Higher bromine substitution and incorporation factors for individual DBP classes were observed for the chlorinated water from the groundwater source (lower concentration of dissolved organic carbon (DOC)), which contained a higher concentration of bromide, than for the surface water source (higher DOC).	Water	115-120	D-box binding PAR bZIP transcription factor	Homo sapiens	69-72
26490534-4	2016	Higher bromine substitution and incorporation factors for individual DBP classes were observed for the chlorinated water from the groundwater source (lower concentration of dissolved organic carbon (DOC)), which contained a higher concentration of bromide, than for the surface water source (higher DOC).	Water	136-141	D-box binding PAR bZIP transcription factor	Homo sapiens	69-72
26784173-1	2016	Aquaporin-2, a member of the aquaporin family, is an arginine vasopressin-regulated water channel expressed in the renal collecting duct, and a promising marker of the concentrating and diluting ability of the kidney.	Water	84-89	arginine vasopressin	Homo sapiens	62-73
26451801-2	2016	The interfacial pressure measured by pendant drop tensiometry reaches 50 mN m(-1) and 35 mN m(-1) for the JPs-MPD at the water/air and water/decane interface, respectively.	Water	121-126	mevalonate diphosphate decarboxylase	Homo sapiens	110-113
26451801-2	2016	The interfacial pressure measured by pendant drop tensiometry reaches 50 mN m(-1) and 35 mN m(-1) for the JPs-MPD at the water/air and water/decane interface, respectively.	Water	135-140	mevalonate diphosphate decarboxylase	Homo sapiens	110-113
27299303-5	2016	Since plasma copeptin and vasopressin have been demonstrated to be sensitive to changes in water intake, inversely associated with 24-hour urine volume, and associated with urine biomarkers and fluid intake, vasopressin is proposed as the central player in this theoretical physiological model.	Water	91-96	arginine vasopressin	Homo sapiens	13-21
26870577-2	2016	The Co(II) atom is octa-hedrally coordinated by the O atom of a water mol-ecule, by one terminally bound carboxyl-ate O atom of an HMal(-) anion and by two O atoms of a chelating HMal(-) anion, as well as by two Cl(-) anions.	Water	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
27161565-2	2016	By reducing vasopressin secretion, increasing water intake may have a beneficial effect on renal function in patients with all forms of chronic kidney disease (CKD) and in those at risk of CKD.	Water	46-51	arginine vasopressin	Homo sapiens	12-23
27161565-5	2016	In polycystic kidney disease (PKD), increased water intake has been shown to slow renal cyst growth in animals via direct vasopressin suppression, and pharmacologic blockade of renal vasopressin-V2 receptors has been shown to slow cyst growth in patients.	Water	46-51	arginine vasopressin	Homo sapiens	122-133
27161565-5	2016	In polycystic kidney disease (PKD), increased water intake has been shown to slow renal cyst growth in animals via direct vasopressin suppression, and pharmacologic blockade of renal vasopressin-V2 receptors has been shown to slow cyst growth in patients.	Water	46-51	arginine vasopressin	Homo sapiens	183-194
26729162-7	2016	Drinking water increases FO when blood carbohydrate and/or insulin concentrations are not elevated and when it is consumed instead of caloric beverages or in volumes that alter hydration status.	Water	9-14	insulin	Homo sapiens	59-66
25384965-4	2016	Proliferative effects of urokinase-type plasminogen activator (uPA) were determined by water-soluble tetrazolium salt-1 assay and by analysis of proliferating cell nuclear antigen expression.	Water	87-92	plasminogen activator, urokinase	Homo sapiens	25-61
27299303-5	2016	Since plasma copeptin and vasopressin have been demonstrated to be sensitive to changes in water intake, inversely associated with 24-hour urine volume, and associated with urine biomarkers and fluid intake, vasopressin is proposed as the central player in this theoretical physiological model.	Water	91-96	arginine vasopressin	Homo sapiens	208-219
27299865-3	2016	SUMMARY: Vasopressin (VP) is the main regulator of body water homeostasis, and at insufficient water intake, normal plasma osmolality can be maintained by increased pituitary VP secretion through VP-2 receptor mediated renal water reabsorption.	Water	56-61	arginine vasopressin	Homo sapiens	9-20
27299865-3	2016	SUMMARY: Vasopressin (VP) is the main regulator of body water homeostasis, and at insufficient water intake, normal plasma osmolality can be maintained by increased pituitary VP secretion through VP-2 receptor mediated renal water reabsorption.	Water	56-61	arginine vasopressin	Homo sapiens	22-24
27299865-7	2016	KEY MESSAGES: With the emerging evidence that high VP, which is present in 25% of the population, is an independent risk factor for diabetes and cardiometabolic disease, VP reduction through water supplementation appears as an attractive candidate intervention to prevent diabetes and its cardiovascular complications.	Water	191-196	arginine vasopressin	Homo sapiens	51-53
27299865-7	2016	KEY MESSAGES: With the emerging evidence that high VP, which is present in 25% of the population, is an independent risk factor for diabetes and cardiometabolic disease, VP reduction through water supplementation appears as an attractive candidate intervention to prevent diabetes and its cardiovascular complications.	Water	191-196	arginine vasopressin	Homo sapiens	170-172
27413750-2	2016	Atrial natriuretic peptide (ANP) considerably influences blood pressure regulation through water and sodium homoeostasis.	Water	91-96	natriuretic peptide A	Homo sapiens	0-26
27413750-2	2016	Atrial natriuretic peptide (ANP) considerably influences blood pressure regulation through water and sodium homoeostasis.	Water	91-96	natriuretic peptide A	Homo sapiens	28-31
26794506-1	2016	Catalase is responsible for converting hydrogen peroxide (H2O2) into water and oxygen in cells.	Water	69-74	catalase	Mus musculus	0-8
26825228-10	2016	Second, the E2f4f/f;E2f5+/-;Vil-cre efferent ducts had completely lost multiciliated cells and greatly reduced levels of critical absorptive cell proteins: aquaporin1, a water channel protein, and clusterin, an endocytic marker.	Water	170-175	E2F transcription factor 5	Mus musculus	20-24
26681182-8	2016	The considerable increase in the concentration of NO3 (-) and dilution of Na(+) and Cl(-) after rain in April in S1 shows how precipitation may change the chemical composition of the water in a 1-day period.	Water	183-188	NBL1, DAN family BMP antagonist	Homo sapiens	50-53
26551587-8	2016	Significant correlations were found between the specific activities of drinking water and free water of milk as well as between the tritium levels of cattle feed dry matter and of the main organic components of milk.	Water	80-85	Weaning weight-maternal milk	Bos taurus	104-108
27274751-1	2016	Tanshinone IIA sodium sulfonate (TSS) is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza.	Water	43-48	ATPase, class II, type 9A	Mus musculus	11-14
27274751-1	2016	Tanshinone IIA sodium sulfonate (TSS) is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza.	Water	43-48	ATPase, class II, type 9A	Mus musculus	82-85
26889254-2	2016	The aim of the present study was to evaluate the effect of a potent, water-soluble antioxidant, protocatechuic aldehyde (PA), which is derived from the Chinese herb Salvia miltiorrhiza, on the expression of FN in human umbilical vein endothelial cells (HUVECs) stimulated with tumor necrosis factor-alpha (TNF-alpha).	Water	69-74	tumor necrosis factor	Homo sapiens	277-304
26889254-2	2016	The aim of the present study was to evaluate the effect of a potent, water-soluble antioxidant, protocatechuic aldehyde (PA), which is derived from the Chinese herb Salvia miltiorrhiza, on the expression of FN in human umbilical vein endothelial cells (HUVECs) stimulated with tumor necrosis factor-alpha (TNF-alpha).	Water	69-74	tumor necrosis factor	Homo sapiens	306-315
26836189-7	2016	Furthermore, although a Morris water maze test probe induced a steep (~4-fold) increment in the percentage of Arc+ cells in the CA3 region of the 10-month-old wild-type group, no such increment was observed in age-matched 3xTg-AD, whereas the amount of Arc+ cells in CA1 increased in both groups.	Water	31-36	carbonic anhydrase 3	Mus musculus	128-131
26836194-7	2016	Mt1 overexpression ameliorated the effects of hAbetaPP on exploration in young females, and potentiated those on anxiety in old males, and seemed to improve the rate of spatial learning (Morris water maze) and the learning elicited by a classical conditioning procedure (eye-blink test).	Water	194-199	metallothionein 1	Mus musculus	0-3
27766179-2	2016	This study constructed a turn off-on-off fluorescent system for PPase activity assay based on PPase-regulated competitive coordination of Cu2+ between a water-soluble fluorescent probe 6,7-dihydroxycoumarin (DHC) and pyrophosphate (PPi).	Water	153-158	inorganic pyrophosphatase 1	Homo sapiens	64-69
27766179-2	2016	This study constructed a turn off-on-off fluorescent system for PPase activity assay based on PPase-regulated competitive coordination of Cu2+ between a water-soluble fluorescent probe 6,7-dihydroxycoumarin (DHC) and pyrophosphate (PPi).	Water	153-158	inorganic pyrophosphatase 1	Homo sapiens	94-99
26581184-2	2016	METHODS: The molecular dynamics simulation using NAMD (Nanoscale Molecular Dynamics) package with the CHARMM 22 (Chemistry at Harvard Macromolecular Mechanics) force field were used to predict dynamic structural changes occurring in the binding site of A1 domain of VWF and N terminus domain of GPIbalpha under water soluble condition.	Water	311-316	von Willebrand factor	Homo sapiens	266-269
27334858-6	2016	A substantial high yield of CD34(+) cells was achieved when patients were treated with a dose-modified IVE regimen, compared with that during the previous regimen (two with the ifosfamide, carboplatin, and etoposide [ICE] regimen, one with high-dose cyclophosphamide and one with the original IVE regimen).	Water	217-220	CD34 molecule	Homo sapiens	28-32
26846459-2	2016	PDE5 inhibitors were extracted from the samples using a 50:50 (v/v) mixture of acetonitrile and water and centrifuged.	Water	96-101	phosphodiesterase 5A	Homo sapiens	0-4
26745439-6	2016	Overall, the effective Mn2O3 sorbent rapidly removed As(III) and As(V) from water in the pH range of 6-9 for natural waters.	Water	76-81	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-70
26788014-2	2016	SPI was stored with two different temperatures (25, 45  C) and two levels of water activity (0.25, 0.75) for 224 days.	Water	77-82	chromogranin A	Homo sapiens	0-3
26551587-8	2016	Significant correlations were found between the specific activities of drinking water and free water of milk as well as between the tritium levels of cattle feed dry matter and of the main organic components of milk.	Water	95-100	Weaning weight-maternal milk	Bos taurus	104-108
26216576-5	2016	Tap water was used as positive control and citric acid as the negative control.	Water	4-9	SEC14 like lipid binding 2	Homo sapiens	0-3
27375740-0	2016	Chronic Exposure to Arsenic in Drinking Water Causes Alterations in Locomotor Activity and Decreases Striatal mRNA for the D2 Dopamine Receptor in CD1 Male Mice.	Water	40-45	dopamine receptor D2	Mus musculus	123-143
26792954-2	2016	The 238U, 210Po and 210Pb concentrations in analyzed water samples reached maximum values of 11.7 +- 0.3, 2.0 +- 0.1 and 3.2 +- 0.1 mBq L-1 and activity ratios were maximally 1.18 +- 0.01 for 234U/238U, 0.041 +- 0.018 for 235U/238U and 0.69 +- 0.10 for 210Po/210Pb.	Water	53-58	immunoglobulin kappa variable 1-16	Homo sapiens	136-139
26699931-2	2016	The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression.	Water	49-54	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	Danio rerio	145-168
26699931-2	2016	The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression.	Water	49-54	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	Danio rerio	170-172
26480200-0	2016	Electrolytically generated acid functional water inhibits NF-kappaB activity by attenuating nuclear-cytoplasmic shuttling of p65 and p50 subunits.	Water	43-48	nuclear factor kappa B subunit 1	Homo sapiens	58-67
26480200-0	2016	Electrolytically generated acid functional water inhibits NF-kappaB activity by attenuating nuclear-cytoplasmic shuttling of p65 and p50 subunits.	Water	43-48	nuclear factor kappa B subunit 1	Homo sapiens	133-136
26480200-2	2016	We have previously demonstrated that electrolytically generated acid functional water (FW) induces the expression of hBD2 in the human oral squamous cell carcinoma (OSCC) cell line Ca9-22.	Water	80-85	defensin beta 4A	Homo sapiens	117-121
26467039-2	2016	AQP1 is a water channel, and under permissive conditions, a nonselective cation channel gated by cGMP.	Water	10-15	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
25757646-4	2016	The drug permeability of the QPM-GSA films was lower than that of the QPM-MSA films in both acidic and neutral media, but higher water uptake of the QPM-GSA films was found at neutral pH.	Water	129-134	GNAS complex locus	Homo sapiens	153-156
26549133-0	2016	Inhibition of the expression of aquaporin-1 by RNA interference in pulmonary epithelial cells and its effects on water transport.	Water	113-118	aquaporin 1 (Colton blood group)	Homo sapiens	32-43
26549133-7	2016	The osmotic water permeability of the AQP1-silenced cells was reduced in the air control and hyperoxia exposure groups, compared with the negative control group 48 and 72 h following exposure.	Water	12-17	aquaporin 1 (Colton blood group)	Homo sapiens	38-42
26549133-8	2016	The volume and cell membrane osmotic water permeability of the A549 cells were reduced, compared with those in the control group following AQP1-silencing, which indicated that the downregulation of AQP1 impedes extracellular to intracellular fluid transportation.	Water	37-42	aquaporin 1 (Colton blood group)	Homo sapiens	198-202
26798423-0	2016	Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model.	Water	14-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	88-92
26798423-3	2016	The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory cytokine levels and promoting healing-associated genes.	Water	61-66	NFE2 like bZIP transcription factor 2	Rattus norvegicus	104-108
26798423-9	2016	In conclusion, hydrogen-rich water intake exhibited multiple beneficial effects through activation of the Nrf2/antioxidant defense pathway.	Water	29-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	106-110
27635190-8	2016	Under the conditions of oxidative stress evoked by serum deprivation the water-soluble fullerene derivative F-828 used in concentrations of 0.1 to 1 microM strongly stimulates the NF-kappaB activity and represses the NRF2 activity in HELFs.	Water	73-78	nuclear factor kappa B subunit 1	Homo sapiens	180-189
27635190-8	2016	Under the conditions of oxidative stress evoked by serum deprivation the water-soluble fullerene derivative F-828 used in concentrations of 0.1 to 1 microM strongly stimulates the NF-kappaB activity and represses the NRF2 activity in HELFs.	Water	73-78	NFE2 like bZIP transcription factor 2	Homo sapiens	217-221
26791767-13	2016	EBI3(rs393581, rs4740 and rs353702), FOXP3(rs2280883, rs2232365 and rs3761548)were associated with the improvement of water discharge in nasal signs.	Water	118-123	Epstein-Barr virus induced 3	Homo sapiens	0-4
27508369-5	2016	KMnO4 released from CRP can effectively degrade phenol-contaminated water with different concentrations.	Water	68-73	C-reactive protein	Homo sapiens	20-23
27073715-0	2016	Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats.	Water	67-72	neuroglobin	Rattus norvegicus	41-52
28124939-3	2016	Vaptans (vasopressin antagonists, vasopressin V2-receptor inhibitors) reduce reabsorption of water in the distal nephron, they increase free water excretion and normalize serum concentrations of sodium in normovolemic and hypervolemic conditions associated with hyponatremia.	Water	93-98	arginine vasopressin	Homo sapiens	9-20
28124939-3	2016	Vaptans (vasopressin antagonists, vasopressin V2-receptor inhibitors) reduce reabsorption of water in the distal nephron, they increase free water excretion and normalize serum concentrations of sodium in normovolemic and hypervolemic conditions associated with hyponatremia.	Water	93-98	arginine vasopressin receptor 2	Homo sapiens	34-57
26607026-0	2015	Spread Films of Human Serum Albumin at the Air-Water Interface: Optimization, Morphology, and Durability.	Water	47-52	albumin	Homo sapiens	28-35
26634958-0	2015	Dewetting of S1-Pocket via Water Channel upon Thrombin-Substrate Association Reaction.	Water	27-32	coagulation factor II, thrombin	Homo sapiens	46-54
26634958-7	2015	These water molecules transferred from the pocket, followed by the specific H-bond formation between thrombin and the substrate.	Water	6-11	coagulation factor II, thrombin	Homo sapiens	101-109
26729089-0	2015	DNA Binding, Photonuclease Activity and Human Serum Albumin Interaction of a Water-Soluble Freebase Carboxyl Corrole.	Water	77-82	albumin	Homo sapiens	46-59
26370794-9	2015	The fermentation product of P. pastoris carrying the recombinant AvBD9 plasmid was adjusted to 1.0 x 10(8) CFU/ml and added to the drinking water of white feather broilers at different concentrations.	Water	140-145	avian beta-defensin 9	Gallus gallus	65-70
26670178-8	2015	This QbD study can form a basis for further development of poorly water soluble AST formulation by oral route with improved bioavailability on larger scale.	Water	66-71	solute carrier family 17 member 5	Homo sapiens	80-83
32263129-5	2015	buffer medium with 1.9 muM NaCN, the threshold limit set by WHO for the safe drinking water and this makes this fluorogenic sensor an ideal candidate for in-field applications.	Water	86-91	latexin	Homo sapiens	23-26
26588204-8	2015	Biodistribution analysis confirms that [Mn(PyC3A)(H2O)](-) clears via a mixed renal/hepatobiliary pathway with &gt;99% elimination by 24 h. [Mn(PyC3A)(H2O)](-) was modified to form a bifunctional chelator and 4 chelates were conjugated to a fibrin-specific peptide to give Mn-FBP.	Water	50-53	ECB2	Homo sapiens	276-279
26426521-1	2015	The first water soluble maleimide bearing NIR BF2-azadipyrromethene (NIR-AZA) fluorochrome has been synthesised which is capable of rapid thiol conjugations in water with peptides such as glutathione, the cell penetrating peptide (CPP) C(beta-A)SKKKKTKV-NH2 and a thiol substituted cRGD.	Water	10-15	forkhead box G1	Homo sapiens	46-49
26467233-1	2015	A heterometallic phenylsilsesquioxane [(PhSiO1,5)22(CoO)3(NaO0.5)6] (EtOH)6 (H2O) 1 cage architecture of Co(II) ions in a triangular topology exhibits a slow dynamic behavior in its magnetization, induced by the freezing of the spins of individual molecules.	Water	77-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
26659061-0	2015	Erratum for the Research Article ""Water-in-salt" electrolyte enables high-voltage aqueous lithium-ion chemistries" by Liumin Suo, Oleg Borodin, Tao Gao, Marco Olguin, Janet Ho, Xiulin Fan, Chao Luo, Chunsheng Wang, Kang Xu.	Water	35-40	neutral sphingomyelinase activation associated factor	Homo sapiens	185-188
26426521-1	2015	The first water soluble maleimide bearing NIR BF2-azadipyrromethene (NIR-AZA) fluorochrome has been synthesised which is capable of rapid thiol conjugations in water with peptides such as glutathione, the cell penetrating peptide (CPP) C(beta-A)SKKKKTKV-NH2 and a thiol substituted cRGD.	Water	160-165	forkhead box G1	Homo sapiens	46-49
26428356-9	2015	The optimal log D7.4 (octanol/water distribution coefficient at pH 7.4) value for inhibition of CYP2E1 was approximately 2.4.	Water	30-35	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	96-102
26485141-7	2015	Sodium arsenite at a dose of 40 mg/L supplied via drinking water in mice significantly raised the serum level of liver function markers such as AST, ALT, and ALP, and caused arsenic deposition in liver and ROS generation, though it did not show any lethality up to 30 days of exposure.	Water	59-64	transmembrane protease, serine 11d	Mus musculus	144-147
26468265-7	2015	In addition, we showed that water deprivation alone upregulated proopiomelanocortin, Agouti-related peptide, melanin-concentrating hormone, and orexin A mRNA levels in the hypothalamus, and that CB1Rs regulate main central peptidergic pathways controlling food intake, being that most of these effects were also significantly influenced by the hydration status.	Water	28-33	hypocretin neuropeptide precursor	Rattus norvegicus	144-152
26400187-5	2015	TNF-alpha increased mean arterial pressure (MAP, P &lt; 0.05) and brain water content in the anterior cerebrum (P &lt; 0.05); however, TNF-alpha infusion had no effect on blood-brain barrier (BBB) permeability in the anterior cerebrum or posterior cerebrum.	Water	72-77	tumor necrosis factor	Rattus norvegicus	0-9
26031227-2	2015	The aim of this study was to evaluate and compare the expression of MRP1 in bronchoalveolar cells from subjects with and without lung cancer who had been chronically exposed to arsenic through drinking water.	Water	202-207	ATP binding cassette subfamily C member 1	Homo sapiens	68-72
26182903-5	2015	METHODS: iPLA2beta-null male mice were administered dextran sodium sulfate in drinking water for 7 days followed by normal water for 3 days.	Water	87-92	phospholipase A2, group VI	Mus musculus	9-18
26182903-5	2015	METHODS: iPLA2beta-null male mice were administered dextran sodium sulfate in drinking water for 7 days followed by normal water for 3 days.	Water	123-128	phospholipase A2, group VI	Mus musculus	9-18
26848303-3	2015	However, high water intake suppresses plasma levels of arginine vasopressin (AVP), which is expected to be beneficial for the preservation of the kidney function.	Water	14-19	arginine vasopressin	Homo sapiens	64-75
26453925-7	2015	Water-soluble superoxide dismutase (SOD) was added in order to suppress the reaction of CHA with O2( -) outside the membrane.	Water	0-5	superoxide dismutase 1	Homo sapiens	36-39
27011977-3	2015	In different water depths, the concentrations of POC and TN in surface were higher than those in deep layer, but the concentration of TP was opposite.	Water	13-18	proopiomelanocortin	Homo sapiens	49-52
26435706-1	2015	Toxic cyanobacteria became more widely recognized as a potential health hazard in the 1990s, and in 1998 the World Health Organization (WHO) first published a provisional Guideline Value of 1 mug L-1 for microcystin-LR in drinking-water.	Water	231-236	immunoglobulin kappa variable 1-16	Homo sapiens	196-199
27011977-12	2015	The source of particle organic matters in water and sediments were plankton and soil organic horizons, the delta13C values of particle organic matters were passively significantly correlated with the concentration of POC and TP (P &lt; 0.05).	Water	42-47	proopiomelanocortin	Homo sapiens	217-220
26747776-12	2015	Beta-B2-crystallin levels decreased in the aqueous and vitreous of EAU but not PMU.	Water	67-70	crystallin, beta B2	Rattus norvegicus	0-18
25855780-2	2015	Because cAMP is a central modulator of arginine vasopressin (AVP)-induced water transport in the renal collecting duct (CD), we hypothesized that if expressed in the CD, P2Y12-R may play a role in renal handling of water in health and in nephrogenic diabetes insipidus.	Water	74-79	arginine vasopressin	Rattus norvegicus	48-59
26747776-14	2015	The neuroprotective protein beta-B2-crystallin was found to decline in EAU.	Water	71-74	crystallin, beta B2	Rattus norvegicus	28-46
26344698-0	2015	Water Proton NMR for In Situ Detection of Insulin Aggregates.	Water	0-5	insulin	Homo sapiens	42-49
26365580-2	2015	AMPKalpha1 knockout mice and wild-type mice were fed either a low-fat diet, high-fat diet or high-fat diet supplemented with betaine in the drinking water for 8weeks.	Water	149-154	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	0-10
26344698-6	2015	In this paper, human insulin preparations were used to demonstrate that the transverse relaxation rate of water protons R2 ((1) H2 O) can serve as a sensitive and reliable indicator to detect and quantify both visible and sub-visible protein aggregates.	Water	106-111	insulin	Homo sapiens	21-28
26702076-6	2015	Heat acclimation did not alter water intake or urine output following administration of hypertonic saline, which selectively stimulates intracellular thirst, but led to greater water intake following administration of angiotensin II, which plays an important role in extracellular/volemic thirst, and following water deprivation, which activates both thirst pathways.	Water	177-182	angiotensinogen	Rattus norvegicus	218-232
26682659-1	2015	At our university-affiliated medical center, a major renovation of the women"s health and birthing unit resulted in the temporary loss of the permanent tub used for water immersion therapy during labor.	Water	165-170	TUB bipartite transcription factor	Homo sapiens	152-155
25970495-0	2015	Rhabdomyolysis After Out-of-Water Exercise in an Elite Adolescent Water Polo Player Carrying the IL-6 174C Allele Single-Nucleotide Polymorphism.	Water	28-33	interleukin 6	Homo sapiens	97-101
25970495-1	2015	We present an adolescent elite water polo player who despite a genetic predisposition to develop exercise-induced severe muscle damage due to carrying the IL-6 174C allele single-nucleotide polymorphism, developed acute rhabdomyolysis only after a vigorous out-of-water training, suggesting that water polo training may be more suitable for genetically predisposed athletes.	Water	31-36	interleukin 6	Homo sapiens	155-159
26278866-3	2015	For the reconstruction of the dural defect, a vascularized pericranial flap was sutured using water-sealed technique.	Water	94-99	arachidonate 5-lipoxygenase activating protein	Homo sapiens	71-75
26526852-4	2015	Comparison of this extensive solvent-mediated hydrogen-bonding network with the positions of ordered solvent in earlier crystallographic structures of rhodopsin photointermediates reveals both static structural and dynamic functional water-protein interactions present during the activation process.	Water	234-239	rhodopsin	Homo sapiens	151-160
26526852-5	2015	When considered along with observations that solvent occupies similar positions in the structures of other GPCRs, these analyses strongly support an integral role for this dynamic ordered water network in both rhodopsin and GPCR activation.	Water	188-193	rhodopsin	Homo sapiens	210-219
26467224-6	2015	For example, LAS delta(2) HVSMOW measurements of USGS50 Lake Kyoga (Uganda) water using an under-performing syringe having +-10 % variation in water concentration gave +31.7 +- 1.6 % (2-sigma standard deviation), compared with the reference value of +32.8 +- 0.4 %, after correction for variation in delta value with water concentration, between-sample memory, and normalization to the VSMOW-SLAP scale.	Water	76-81	Src like adaptor	Homo sapiens	392-396
26607179-3	2015	Here we show that Arabidopsis AtPIP1;4 is a plasma membrane sensor of Hpa1 and plays a dual role in plasma membrane permeability of CO2 and H2O.	Water	140-143	plasma membrane intrinsic protein 1;4	Arabidopsis thaliana	30-38
26617986-6	2015	A total of 11 inorganic water-soluble ions in the TSP and PM10 were identified by ion chromatography (IC).	Water	24-29	thrombospondin 1	Homo sapiens	50-53
26617986-10	2015	This study showed that the water soluble salts compose 3-20% of the total mass of TSP and PM10.	Water	27-32	thrombospondin 1	Homo sapiens	82-85
26603245-0	2015	Effect of increased water intake on plasma copeptin in patients with chronic kidney disease: results from a pilot randomised controlled trial.	Water	20-25	arginine vasopressin	Homo sapiens	43-51
26611539-0	2015	Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation.	Water	25-30	NFE2 like bZIP transcription factor 2	Homo sapiens	103-107
26602442-1	2015	HPLW, a designed VEGF (Vascular Endothelium Growth Factor) receptor-binding peptide, assumes a well folded beta-hairpin conformation in water and is able to induce angiogenesis in vivo.	Water	136-141	vascular endothelial growth factor A	Homo sapiens	17-21
26293614-9	2015	We confirmed the direct interaction between C3(H2O) and CD11b by quartz crystal microbalance analysis using purified native C3 and recombinant CD11b/CD18 and by flow cytometry using PMP and recombinant CD11b.	Water	47-50	integrin subunit beta 2	Homo sapiens	149-153
26603245-1	2015	OBJECTIVES: Increased water intake may have a beneficial effect on the kidney through suppression of plasma vasopressin.	Water	22-27	arginine vasopressin	Homo sapiens	108-119
26293614-10	2015	Transfectants expressing CD11b/CD18 were also shown to specifically adhere to surface-bound C3(H2O).	Water	95-98	integrin subunit beta 2	Homo sapiens	31-35
26603245-2	2015	We examined the effect of increased water intake on plasma copeptin (a marker of vasopressin) over 6 weeks in patients with chronic kidney disease.	Water	36-41	arginine vasopressin	Homo sapiens	59-67
26293614-11	2015	We have identified contact-activated C3(H2O) as a novel ligand for CD11b/CD18 that mediates PPC formation and the binding of PMPs to PMNs.	Water	40-43	integrin subunit beta 2	Homo sapiens	73-77
26603245-14	2015	This increased water intake caused a significant decrease in plasma copeptin concentration.	Water	15-20	arginine vasopressin	Homo sapiens	68-76
26439450-4	2015	Reactions of Cu(NO3 )2  2.5 H2 O, CuO, and ZnO with the neat 2:1 1-mim/4,5-DCNIm melt resulted in the isolation of entirely N-donor ligated complexes of the formula M(4,5-DCNIm)2 (1-mim)4 (M=Cu, Zn).	Water	28-32	NBL1, DAN family BMP antagonist	Homo sapiens	13-19
26511073-5	2015	The "fast" and "slow" processes with an Arrhenius temperature dependence are attributed to ice and supercooled water relaxation, respectively.	Water	111-116	carboxylesterase 2	Homo sapiens	91-94
26571021-4	2015	We recently showed that this soluble CSP, combined with a synthetic Toll-like-receptor-4 (TLR4) agonist in stable oil-in-water emulsion (GLA/SE), induces a potent and protective immune response in mice against transgenic parasite challenge.	Water	121-126	DnaJ heat shock protein family (Hsp40) member C5	Mus musculus	37-40
26468911-0	2015	Protein-Drug Interactions with Effective Polarization in Polarizable Water: Oxime Unbinding from AChE Gorge.	Water	69-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-101
26468911-2	2015	We present oxime (HI-6) unbinding from the active site gorge of AChE, known to be strongly influenced by intermolecular cation-pi, hydrogen bridge (HB) and water bridge (WB) interactions and by molecular simulations with effective polarization in polarizable mean-field model of TIP3P water.	Water	156-161	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
26468911-2	2015	We present oxime (HI-6) unbinding from the active site gorge of AChE, known to be strongly influenced by intermolecular cation-pi, hydrogen bridge (HB) and water bridge (WB) interactions and by molecular simulations with effective polarization in polarizable mean-field model of TIP3P water.	Water	285-290	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
26563764-8	2015	The beta5-alpha7 loop, unique for CNPase in the 2H phosphoesterase family, appears to have various functions in the CNPase reaction mechanism, from coordinating the nucleophilic water molecule to providing a binding pocket for the product and being involved in product release.	Water	178-183	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	34-40
26563764-8	2015	The beta5-alpha7 loop, unique for CNPase in the 2H phosphoesterase family, appears to have various functions in the CNPase reaction mechanism, from coordinating the nucleophilic water molecule to providing a binding pocket for the product and being involved in product release.	Water	178-183	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	116-122
26492498-2	2015	This study reports the novel utilization of soy protein isolate (SPI) as fluid loss additive in bentonite-water based drilling fluids (BT-WDFs) and describes how its particle size and concentration influence on the filtration property of SPI/BT-WDFs.	Water	106-111	chromogranin A	Homo sapiens	65-68
26571021-4	2015	We recently showed that this soluble CSP, combined with a synthetic Toll-like-receptor-4 (TLR4) agonist in stable oil-in-water emulsion (GLA/SE), induces a potent and protective immune response in mice against transgenic parasite challenge.	Water	121-126	toll-like receptor 4	Mus musculus	90-94
26421324-2	2015	In aqueous solution, 2-thiophenone and 4-hydroxymethyl-1,3-dioxolan-2-one (HD) at a concentration of 2% by volume can increase the average charge of cytochrome c and myoglobin by up to 163%, resulting in even higher charge states than those that are produced from water/methanol/acid solutions in which these proteins are denatured.	Water	264-269	cytochrome c, somatic	Homo sapiens	149-161
26555167-0	2015	TECPR2 Associated Neuroaxonal Dystrophy in Spanish Water Dogs.	Water	51-56	tectonin beta-propeller repeat containing 2	Canis lupus familiaris	0-6
26421917-3	2015	Here we consider an IDR of the tumor suppressor p53 protein, p53CTD, as an important example related to carcinogenesis and analyze its binding to four targets accompanying the formation of target-dependent structures (i.e., helix, sheet, and two different coils) using our statistical-mechanical method combined with molecular models for water.	Water	338-343	tumor protein p53	Homo sapiens	48-51
27293584-4	2015	Herein we describe the stepwise optimisation of reaction parameters (pH, reagent concentrations and reaction time) for the room temperature, water-based synthesis of several members of the CPO-27/MOF-74-M series of MOFs, including ones made from Mg(II), Ni(II), Co(II) and Zn(II) ions.	Water	141-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-268
26256355-1	2015	In this study, a water-soluble polysaccharide (CSP) was successfully purified from Chaenomeles speciosa by DEAE-Sepharose and Sephadex G-100 column chromatography.	Water	17-22	DnaJ heat shock protein family (Hsp40) member C5	Mus musculus	47-50
26578982-1	2015	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and plays an important role in the maintenance of body water homeostasis.	Water	48-53	arginine vasopressin	Homo sapiens	26-37
26462594-1	2015	2,2"-bis(4-hydroxyphenyl) propane (BPA) and its metabolites 4-methyl-2,4-bis(p-hydroxyphenyl)pent-2-ene (M-1) and 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (M-2) are common in drinking water and hard plastics and thus pose serious health hazards.	Water	187-192	myoregulin	Homo sapiens	105-108
26529243-0	2015	Human Lipocalin-Type Prostaglandin D Synthase-Based Drug Delivery System for Poorly Water-Soluble Anti-Cancer Drug SN-38.	Water	84-89	prostaglandin D2 synthase	Homo sapiens	6-45
26578982-1	2015	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and plays an important role in the maintenance of body water homeostasis.	Water	82-87	arginine vasopressin	Homo sapiens	26-37
26529243-2	2015	Using this function, we have reported the feasibility of using L-PGDS as a novel drug delivery vehicle for poorly water-soluble drugs.	Water	114-119	prostaglandin D2 synthase	Homo sapiens	63-69
26578982-1	2015	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and plays an important role in the maintenance of body water homeostasis.	Water	82-87	arginine vasopressin	Homo sapiens	26-37
26529243-3	2015	In this study, we show the development of a drug delivery system using L-PGDS, one that enables the direct clinical use of 7-ethyl-10-hydroxy-camptothecin (SN-38), a poorly water-soluble anti-cancer drug.	Water	173-178	prostaglandin D2 synthase	Homo sapiens	71-77
27551476-4	2015	Modified citrus pectin (MCP) is a water-soluble citrus-fruit-derived polysaccharide fiber that specifically inhibits Gal-3.	Water	34-39	lectin, galactose binding, soluble 3	Mus musculus	117-122
26527034-13	2015	Administration of r-PGRN decreased brain water content and improved neurological scores at 24 h after SAH.	Water	41-46	granulin precursor	Homo sapiens	18-24
26372856-8	2015	Because ABCG2 binds its allocrites with higher affinity than ABCB1, it can extract hydrophilic, nonamphiphilic, and highly charged compounds out of the lipid membrane, typically exhibiting low lipid-water partition coefficients, but is inhibited by hydrophobic, amphiphilic, and moderately charged compounds, with high lipid-water partition coefficients.	Water	199-204	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	8-13
26372856-8	2015	Because ABCG2 binds its allocrites with higher affinity than ABCB1, it can extract hydrophilic, nonamphiphilic, and highly charged compounds out of the lipid membrane, typically exhibiting low lipid-water partition coefficients, but is inhibited by hydrophobic, amphiphilic, and moderately charged compounds, with high lipid-water partition coefficients.	Water	199-204	ATP binding cassette subfamily B member 1	Homo sapiens	61-66
26372856-8	2015	Because ABCG2 binds its allocrites with higher affinity than ABCB1, it can extract hydrophilic, nonamphiphilic, and highly charged compounds out of the lipid membrane, typically exhibiting low lipid-water partition coefficients, but is inhibited by hydrophobic, amphiphilic, and moderately charged compounds, with high lipid-water partition coefficients.	Water	325-330	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	8-13
26372856-8	2015	Because ABCG2 binds its allocrites with higher affinity than ABCB1, it can extract hydrophilic, nonamphiphilic, and highly charged compounds out of the lipid membrane, typically exhibiting low lipid-water partition coefficients, but is inhibited by hydrophobic, amphiphilic, and moderately charged compounds, with high lipid-water partition coefficients.	Water	325-330	ATP binding cassette subfamily B member 1	Homo sapiens	61-66
25847773-1	2015	OBJECTIVE: To observe the effects of water extract of Zuojin Pill ([characters: see text], ZJP) on inhibiting the growth of human gastric cancer cell line SGC-7901 and its potential mechanism.	Water	37-42	sarcoglycan beta	Homo sapiens	155-158
26600892-4	2015	A water deprivation test with vasopressin challenge, though has limitations, is done to differentiate NDI from CDI and diagnose their incomplete forms.	Water	2-7	arginine vasopressin	Homo sapiens	30-41
26342025-9	2015	Further, we found that the water content of the tissue was positively correlated with the levels of plasma 5-hydroxyindoleacetic acid or tissue aquaporin-1 but not with CD31.	Water	27-32	aquaporin 1 (Colton blood group)	Homo sapiens	144-155
26450514-5	2015	The limits of quantification for both drugs were 5 mug L-1 in water sample and 10 mug L-1 in biological fluids with R2 values higher than 0.993.	Water	62-67	immunoglobulin kappa variable 1-16	Homo sapiens	55-58
26209759-5	2015	In this way, the hydration functions and water factors of fibrinogen monolayers were quantitatively evaluated for various pHs.	Water	41-46	fibrinogen beta chain	Homo sapiens	58-68
26529487-9	2015	Induction of water molecules during molecular docking simulation explored differences in the hinge region between PIM-1 and PIM-3 kinases that may be responsible for specificity.	Water	13-18	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	114-119
26123666-3	2015	The results of MTLC confirmed that between the two hydrophobicity parameters km and Pm/w, for absorption prediction of 11 ACE inhibitors, the micelle-water partition coefficient Pm/w provided higher correlation (R(2) = 0.756), while for the km parameter R(2) = 0.612 was obtained.	Water	150-155	angiotensin I converting enzyme	Homo sapiens	122-125
26242895-10	2015	Biofilm production was associated with the presence of esp (P &lt; 0.001) and ace genes (P = 0.021), being higher in infecting (P &lt; 0.001) and water (P 0.005) isolates as compared with colonizing ones.	Water	146-151	angiotensin I converting enzyme	Homo sapiens	78-81
26163769-0	2015	Cytosolic glutamine synthetase is important for photosynthetic efficiency and water use efficiency in potato as revealed by high-throughput sequencing QTL analysis.	Water	78-83	glutamine synthetase	Solanum tuberosum	10-30
26452915-8	2015	The proposed method gives a good recovery rate of Pb(II) ions in real-life water samples such as tap water and river water.	Water	75-80	submaxillary gland androgen regulated protein 3B	Homo sapiens	50-56
26452915-8	2015	The proposed method gives a good recovery rate of Pb(II) ions in real-life water samples such as tap water and river water.	Water	101-106	submaxillary gland androgen regulated protein 3B	Homo sapiens	50-56
26452915-8	2015	The proposed method gives a good recovery rate of Pb(II) ions in real-life water samples such as tap water and river water.	Water	101-106	submaxillary gland androgen regulated protein 3B	Homo sapiens	50-56
26620256-1	2015	Antidiuretic hormone or arginine vasopressin (AVP) increases water reabsorption in the collecting ducts of the kidney.	Water	61-66	arginine vasopressin	Homo sapiens	33-44
26451632-0	2015	Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"".	Water	72-77	carboxylesterase 2	Homo sapiens	192-195
27215024-4	2015	RESULTS: OVA combined with thyroxin was an appropriate method to induce the mouse model with increased food and water intake, autonomous activity, asthmatic behaviors score, and respiratory rate, decreased body weight, tidal volume, and wet/dry ratio of lung, and changed with pathology of lung tissue.	Water	112-117	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	9-12
27132459-0	2015	[Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with traumatic brain injury].	Water	26-31	NFE2 like bZIP transcription factor 2	Rattus norvegicus	53-58
27132459-1	2015	OBJECTIVE: To investigate the effects of hydrogen rich water on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and oxidative stress in rats with traumatic brain injury (TBI).	Water	55-60	NFE2 like bZIP transcription factor 2	Rattus norvegicus	82-125
27132459-1	2015	OBJECTIVE: To investigate the effects of hydrogen rich water on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and oxidative stress in rats with traumatic brain injury (TBI).	Water	55-60	NFE2 like bZIP transcription factor 2	Rattus norvegicus	127-131
27132459-20	2015	CONCLUSIONS: Hydrogen rich water can up-regulate the expression of Nrf2, and reduce oxidative damage of traumatic brain injury in rats.	Water	27-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	67-71
26344240-7	2015	These results suggest that the deactivation of CeA facilitatory mechanisms by muscimol injection into the CeA is promoted by endogenous angiotensin II acting on AT1 receptors in the CeA, which prevents rats from ingesting large amounts of hypertonic NaCl and water.	Water	259-264	angiotensinogen	Rattus norvegicus	136-150
26451632-0	2015	Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"".	Water	72-77	carboxylesterase 2	Homo sapiens	192-195
26506513-2	2015	The catalytic mechanism of BACE-1 requires water-mediated proton transfer from aspartyl dyad to the substrate, as well as structural flexibility in the flap region.	Water	43-48	beta-secretase 1	Homo sapiens	27-33
26399304-6	2015	Further QM calculations of the Pd(PPh3)2-H2O system confirmed the direction (PdH) and stability of this bonding.	Water	41-44	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	77-80
26516441-12	2015	We recommend selective oral administration of vasopressin V2-receptor antagonist, tolvaptan, which acts to increase the excretion of free water, thereby resolving hypervolemic hyponatremia and may have the potential to improve outcomes in these patients.	Water	138-143	arginine vasopressin receptor 2	Homo sapiens	46-69
26493911-1	2015	We examine the thermal fluctuations of the local electric field Ek (loc) and the dipole moment muk in liquid water at T = 298 K between metal walls in electric field applied in the perpendicular direction.	Water	109-114	mitogen-activated protein kinase kinase kinase 12	Homo sapiens	95-98
26503226-1	2015	BACKGROUND: Arginine vasopressin (AVP), a neuropeptide hormone that functions in the regulation of water homeostasis by controlling water re-absorption at kidneys, is synthesised in supraoptic nucleus and paraventricular nucleus of the hypothalamus.	Water	99-104	arginine vasopressin	Rattus norvegicus	12-32
26503226-1	2015	BACKGROUND: Arginine vasopressin (AVP), a neuropeptide hormone that functions in the regulation of water homeostasis by controlling water re-absorption at kidneys, is synthesised in supraoptic nucleus and paraventricular nucleus of the hypothalamus.	Water	99-104	arginine vasopressin	Rattus norvegicus	34-37
26503226-1	2015	BACKGROUND: Arginine vasopressin (AVP), a neuropeptide hormone that functions in the regulation of water homeostasis by controlling water re-absorption at kidneys, is synthesised in supraoptic nucleus and paraventricular nucleus of the hypothalamus.	Water	132-137	arginine vasopressin	Rattus norvegicus	12-32
26503226-1	2015	BACKGROUND: Arginine vasopressin (AVP), a neuropeptide hormone that functions in the regulation of water homeostasis by controlling water re-absorption at kidneys, is synthesised in supraoptic nucleus and paraventricular nucleus of the hypothalamus.	Water	132-137	arginine vasopressin	Rattus norvegicus	34-37
26770645-8	2015	Since ManLAM is the major component of water phase, we found that ManLAM induced IL-37 mRNA and protein expression in a time and dose-dependent manner, while this activity was almost totally abolished by the ERK1/2 (U0126) and p38 (SB203580) inhibitor.	Water	39-44	mitogen-activated protein kinase 3	Homo sapiens	208-214
26411334-0	2015	Spectroscopic and Microscopic Studies of Aggregation and Fibrillation of Lysozyme in Water/Ethanol Solutions.	Water	85-90	lysozyme	Homo sapiens	73-81
26411334-1	2015	The thermal aggregation of lysozyme has been analyzed in water/ethanol solutions at low pH to induce the specific protein aggregation pathway which leads to fibrillar structures in a few hours.	Water	57-62	lysozyme	Homo sapiens	27-35
26370442-3	2015	Reaction of H3L with CuCl2 forms a mononuclear copper(ii) [Cu(Cl)(H2L)(H2O)] (H2L-Cu(2+)) complex which is characterized by conventional techniques and quantum chemical calculations.	Water	71-75	H3 clustered histone 2	Homo sapiens	12-15
26143270-11	2015	In real water, the presence of NOM significantly decreased the bromate formation but caused the brominated organic DBP formation with high quantity.	Water	8-13	D-box binding PAR bZIP transcription factor	Homo sapiens	115-118
26456695-2	2015	Here we report mum-long, dynamic tubular pores that undergo rapid switching between open and closed states in response to a thermal signal in water.	Water	142-147	latexin	Homo sapiens	15-18
26574244-4	2015	Moreover, drug transit from bulk water into the DBP was characterized as an overall free-energy downhill process.	Water	33-38	D-box binding PAR bZIP transcription factor	Homo sapiens	48-51
26143263-4	2015	PGD2-MS were prepared using an oil-in-water emulsion solvent extraction-evaporation process, and the size, zeta potential, surface morphology and encapsulation efficiency were determined.	Water	38-43	prostaglandin D2 synthase	Homo sapiens	0-7
26445439-6	2015	Moreover, our osmotic stressing and D2O-H2O exchange experiments demonstrate that myelin lacking claudin-11 is more permeable to water and small osmolytes.	Water	40-43	claudin 11	Homo sapiens	97-107
26371748-12	2015	The AFP fusion crystallization method can potentially be used to force the exposure to solvent of the IBS on other AFPs to reveal the locations of key surface waters.	Water	159-165	alpha fetoprotein	Homo sapiens	4-7
26443076-4	2015	Further X-ray structure and SAR analyses revealed that the potencies of the designed inhibitors were partly attributable to additional water-mediated hydrogen bond networks formed by an unexpected buried water between hDHODH and the 2-(2-methylenehydrazinyl)thiazole scaffold.	Water	135-140	dihydroorotate dehydrogenase (quinone)	Homo sapiens	218-224
26443076-4	2015	Further X-ray structure and SAR analyses revealed that the potencies of the designed inhibitors were partly attributable to additional water-mediated hydrogen bond networks formed by an unexpected buried water between hDHODH and the 2-(2-methylenehydrazinyl)thiazole scaffold.	Water	204-209	dihydroorotate dehydrogenase (quinone)	Homo sapiens	218-224
26445439-6	2015	Moreover, our osmotic stressing and D2O-H2O exchange experiments demonstrate that myelin lacking claudin-11 is more permeable to water and small osmolytes.	Water	129-134	claudin 11	Homo sapiens	97-107
26443076-5	2015	This work not only elucidates promising scaffolds targeting hDHODH for the treatment of rheumatoid arthritis, but also demonstrates that the water-mediated hydrogen bond interaction is an important factor in molecular design and optimization.	Water	141-146	dihydroorotate dehydrogenase (quinone)	Homo sapiens	60-66
26338143-0	2015	Fate of Extended-Spectrum beta-Lactamase-Producing Escherichia coli from Faecal Sources in Surface Water and Probability of Human Exposure through Swimming.	Water	99-104	EsbL	Escherichia coli	8-40
26269596-3	2015	In the water hydrogen bond network the neurokinin-1 has a unique Glu residue instead of the highly conserved AspII:10 (2.50).	Water	7-12	tachykinin precursor 1	Homo sapiens	39-51
26100336-3	2015	Aquaporin-4 (AQP4) and Aquaporin-9 (AQP9) play an important role in maintaining brain water homeostasis under various conditions.	Water	86-91	aquaporin 9	Homo sapiens	23-34
26100336-3	2015	Aquaporin-4 (AQP4) and Aquaporin-9 (AQP9) play an important role in maintaining brain water homeostasis under various conditions.	Water	86-91	aquaporin 9	Homo sapiens	36-40
26271894-0	2015	Hydrogen-rich water attenuates amyloid beta-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.	Water	14-19	forkhead box O3	Homo sapiens	95-101
26220580-7	2015	According to the transporter database, 80% of the proton antiporter inhibitor candidates could inhibit P-glycoprotein/MDR1/ABCB1 and specificity is improved by reducing inhibitor size/shape and increasing water solubility.	Water	205-210	ATP binding cassette subfamily B member 1	Homo sapiens	118-122
25773009-5	2015	In serum, the expected increase of the water-soluble vitamins folate and vitamin B12 was observed with a concomitant decrease in homocysteine.	Water	39-44	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	81-84
26220580-7	2015	According to the transporter database, 80% of the proton antiporter inhibitor candidates could inhibit P-glycoprotein/MDR1/ABCB1 and specificity is improved by reducing inhibitor size/shape and increasing water solubility.	Water	205-210	ATP binding cassette subfamily B member 1	Homo sapiens	123-128
26247402-2	2015	Hepatocytes express aquaporin (AQP) 0, 8, 9, 11, and 12; this study investigates whether increasing the localization of AQP8 on the cellular membrane would improve cell viability by increasing water transport during cryopreservation.	Water	193-198	aquaporin 8	Rattus norvegicus	120-124
26099932-6	2015	In subgroup analyses, pancreatic lipid content was ~4-fold higher in youth with type 2 diabetes who were carriers of the G319S mutation in the HNF-1alpha gene (7.45 [2.85, 26.8] vs. 2.20 [0.350, 3.30] % Fat to Water Ratio F/W; p=0.032).	Water	210-215	HNF1 homeobox A	Homo sapiens	143-153
26077742-3	2015	Water permeability in the collecting duct is regulated by arginine vasopressin (AVP).	Water	0-5	arginine vasopressin	Homo sapiens	67-78
26117330-1	2015	Catalase is an important antioxidant enzyme that dismutates hydrogen peroxide into water and molecular oxygen.	Water	83-88	catalase	Homo sapiens	0-8
26373378-2	2015	Soft X-ray (SXR) radiation, from "water window" spectral range, lambda=2.3-4.4 nm wavelength, which is particularly suitable for biological imaging due to natural optical contrast provides better spatial resolution than one obtained with visible light microscopes.	Water	34-39	nuclear receptor subfamily 1 group I member 2	Homo sapiens	12-15
26077742-3	2015	Water permeability in the collecting duct is regulated by arginine vasopressin (AVP).	Water	0-5	arginine vasopressin	Homo sapiens	80-83
26077742-5	2015	AVP facilitates aquaporin (AQP)-mediated water reabsorption via activation of the vasopressin V2 receptor (AVPR2) in the collecting duct, thus enabling concentration of urine.	Water	41-46	arginine vasopressin	Homo sapiens	0-3
26385707-0	2015	Soshiho-tang water extract inhibits ovalbumin-induced airway inflammation via the regulation of heme oxygenase-1.	Water	13-18	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	36-45
26337615-4	2015	Atomistic simulations reveal that hydrogen bond formation and the mean lifetime of hydration waters of the poly(ethylene oxide) (or PEO) groups are location-dependent in the HEUR micelle, with PEO groups immediately adjacent to the C16 groups forming the fewest hydrogen bonds with water and having hydration waters with longer lifetimes than those of the PEO groups located further away from the C16 groups.	Water	93-98	twinkle mtDNA helicase	Homo sapiens	132-135
26337615-4	2015	Atomistic simulations reveal that hydrogen bond formation and the mean lifetime of hydration waters of the poly(ethylene oxide) (or PEO) groups are location-dependent in the HEUR micelle, with PEO groups immediately adjacent to the C16 groups forming the fewest hydrogen bonds with water and having hydration waters with longer lifetimes than those of the PEO groups located further away from the C16 groups.	Water	93-98	twinkle mtDNA helicase	Homo sapiens	193-196
26337615-4	2015	Atomistic simulations reveal that hydrogen bond formation and the mean lifetime of hydration waters of the poly(ethylene oxide) (or PEO) groups are location-dependent in the HEUR micelle, with PEO groups immediately adjacent to the C16 groups forming the fewest hydrogen bonds with water and having hydration waters with longer lifetimes than those of the PEO groups located further away from the C16 groups.	Water	93-98	twinkle mtDNA helicase	Homo sapiens	193-196
26010417-3	2015	There was a linear correlation between the water potential (Psi) at 50% loss of hydraulic conductivity (P50 ) and the Psi at maximum AE activity (Pmaxrate ), where species with lower P50 also had lower Pmaxrate (P &lt; 0.001, R(2)  = 0.76).	Water	43-48	nuclear factor kappa B subunit 1	Homo sapiens	104-107
26010417-3	2015	There was a linear correlation between the water potential (Psi) at 50% loss of hydraulic conductivity (P50 ) and the Psi at maximum AE activity (Pmaxrate ), where species with lower P50 also had lower Pmaxrate (P &lt; 0.001, R(2)  = 0.76).	Water	43-48	nuclear factor kappa B subunit 1	Homo sapiens	183-186
25445057-3	2015	NEW METHOD: We stereotactically injected the vasoconstrictor endothelin-1 (ET-1) close to the ACA of rats and assessed magnitude and course of CBF reduction using [(14)C]iodoantipyrine autoradiography and [(15)O]H2O-PET.	Water	212-215	endothelin 1	Rattus norvegicus	61-73
26428993-9	2015	The new algorithm retains all the advantages of the original one whilst exhibiting excellent energy conservation as illustrated for a Lennard-Jones liquid and SPC/E water.	Water	165-170	proline rich protein gene cluster	Homo sapiens	159-162
26395714-6	2015	We here show how different popular water models (TIP4P/2005, TIP4P, SPC/E, TIP5P, and TIP3P) perform in reproducing thermodynamic and dynamic experimental properties in the supercritical region.	Water	35-40	proline rich protein gene cluster	Homo sapiens	68-71
26385707-0	2015	Soshiho-tang water extract inhibits ovalbumin-induced airway inflammation via the regulation of heme oxygenase-1.	Water	13-18	heme oxygenase 1	Mus musculus	96-112
26074089-1	2015	Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates salt-water balance and blood pressure by promoting renal sodium and water excretion and stimulating vasodilation.	Water	74-79	natriuretic peptide A	Homo sapiens	0-26
26317410-2	2015	In the present study, a water-soluble polysaccharide fraction (SCP-1) was prepared from S. constricta by enzyme-assisted extraction and purification of chromatography with DEAE-52 cellulose anion-exchange column and Sephadex G-100 size exclusion column.	Water	24-29	stem cell proliferation 1	Mus musculus	63-68
26270568-5	2015	Two chemically very similar chloro-aromatic fragments differ strongly in their potency (430 muM vs 10 mM); their binding modes are related, but the surrounding residual water network differs.	Water	169-174	latexin	Homo sapiens	92-95
26220800-5	2015	In this study, water samples with native microcystins were oxidized to cleave the Adda moiety, common to all microcystin variants.	Water	15-20	adducin 1	Homo sapiens	82-86
26359634-0	2015	Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets.	Water	0-5	argonaute RISC catalytic component 2	Homo sapiens	51-61
26074089-1	2015	Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates salt-water balance and blood pressure by promoting renal sodium and water excretion and stimulating vasodilation.	Water	74-79	natriuretic peptide A	Homo sapiens	28-31
26380101-10	2015	lpr-CU group had a 20% survival advantage over lpr-water group.	Water	51-56	Fas (TNF receptor superfamily member 6)	Mus musculus	47-50
26354713-5	2015	There was significant discrepancy between the EF values of PCB-183 and the racemic values, indicating that stereoselective depletion of PCB-183 was probably associated with the water-air exchange.	Water	177-182	pyruvate carboxylase	Homo sapiens	59-62
26354713-5	2015	There was significant discrepancy between the EF values of PCB-183 and the racemic values, indicating that stereoselective depletion of PCB-183 was probably associated with the water-air exchange.	Water	177-182	pyruvate carboxylase	Homo sapiens	136-139
26088210-4	2015	Through learning from the nature"s strategy for water preservation, the hydrophobic/hydrophilic cooperative Janus system that achieved reinforced fog collection ability is reported here.	Water	48-53	zinc finger protein, FOG family member 1	Homo sapiens	146-149
26380101-12	2015	CU/TU treatment inhibited lymphadenopathy significantly compared with lpr-water group (p=0.03 and p=0.02, respectively) by induction of apoptosis.	Water	74-79	Fas (TNF receptor superfamily member 6)	Mus musculus	70-73
26053965-6	2015	The maximum flow rates and pressures generated by the pump using DI water as a working buffer are 10 nL min(-1) and 30 Pa, respectively.	Water	65-73	CD59 molecule (CD59 blood group)	Homo sapiens	104-110
26380101-13	2015	Average lymph node weights were 2606+-1147, 742+-331 and 385+-68 mg, respectively, for lpr-water, lpr-CU and lpr-TU mice.	Water	91-96	Fas (TNF receptor superfamily member 6)	Mus musculus	87-90
26380101-15	2015	Significantly reduced cellular infiltration of the salivary glands in the lpr-TU group compared with the lpr-water group, and a trend towards reduced kidney damage was observed in the lpr-CU and lpr-TU groups.	Water	109-114	Fas (TNF receptor superfamily member 6)	Mus musculus	105-108
26380101-15	2015	Significantly reduced cellular infiltration of the salivary glands in the lpr-TU group compared with the lpr-water group, and a trend towards reduced kidney damage was observed in the lpr-CU and lpr-TU groups.	Water	109-114	Fas (TNF receptor superfamily member 6)	Mus musculus	105-108
26368406-2	2015	From the variation in the amplified spontaneous emission noise intensity with respect to the modulation frequency of the gain switching, the optical length of a 1-km single-mode fiber immersed in water is found to be 1471.043915 m +- 33 mum, corresponding to a relative standard deviation of 2.2 x 10(-8).	Water	196-201	latexin	Homo sapiens	237-240
26380101-15	2015	Significantly reduced cellular infiltration of the salivary glands in the lpr-TU group compared with the lpr-water group, and a trend towards reduced kidney damage was observed in the lpr-CU and lpr-TU groups.	Water	109-114	Fas (TNF receptor superfamily member 6)	Mus musculus	105-108
26273843-6	2015	Reported results show that glutathione attached CNT-bridged 3D graphene oxide membrane can be used to remove As(III), As(V), and Pb(II) from water sample at 10 ppm level.	Water	141-146	submaxillary gland androgen regulated protein 3B	Homo sapiens	129-135
26339489-1	2015	BACKGROUND: Ice swimming for 1 mile and 1 km is a new discipline in open-water swimming since 2009.	Water	73-78	carboxylesterase 2	Homo sapiens	12-15
26340563-8	2015	Our observations provide a possible reason for the ability of KPC-2 beta-lactamase to slowly desulfate avibactam with a potential role for the stereochemistry around the N1 atom of avibactam and/or the presence of an active site water molecule that could aid in avibactam desulfation, an unexpected consequence of novel inhibition chemistry.	Water	229-234	carbapenem-hydrolyzing beta-lactamase KPC-2	Klebsiella pneumoniae	62-67
28454943-1	2015	Soy protein isolate (SPI) can act as effective nanocarriers for water-insoluble curcumin, however, the maximal capacity of this protein to load curcumin and molecular mechanism for the formation of the nanocomplexes are still little known.	Water	64-69	chromogranin A	Homo sapiens	21-24
26168975-3	2015	Among the optimized DESI parameters, the solvent (acetonitrile/water, 80:20, v/v) and the sample substrate (poly-tetrafluoroethylene, PTFE) were critical to obtain the best sensitivity.	Water	63-68	desumoylating isopeptidase 2	Homo sapiens	20-24
26331261-6	2015	Interestingly, our data show that the reconfiguration dynamics of CGRP is significantly slower than that of human IAPP in water but not in denaturant, providing experimental evidence for roughness in the energy landscape, or internal friction, in these peptides.	Water	122-127	calcitonin related polypeptide alpha	Homo sapiens	66-70
25921760-3	2015	The results showed that ESBL-producing E. coli from swine feces and downstream water of the pig farm outfall overlapped substantially in drug resistance and ESBL genes.	Water	79-84	EsbL	Escherichia coli	24-28
25921760-3	2015	The results showed that ESBL-producing E. coli from swine feces and downstream water of the pig farm outfall overlapped substantially in drug resistance and ESBL genes.	Water	79-84	EsbL	Escherichia coli	157-161
25921760-4	2015	Additionally, six ESBL-producing E. coli from the downstream water exhibited 100 % genetic similarity with strains from the swine feces.	Water	61-66	EsbL	Escherichia coli	18-22
26197201-4	2015	Pharmacologic regulation of AQP1, either through increased expression or gating, is associated with increased water transport in rodent models of peritoneal dialysis.	Water	110-115	aquaporin 1 (Colton blood group)	Homo sapiens	28-32
25605059-2	2015	HX106N, a water-soluble botanical formulation, has previously been demonstrated to prevent amyloid beta-induced memory impairment and oxidative stress in mice by upregulating HO-1 levels.	Water	10-15	heme oxygenase 1	Mus musculus	175-179
28454943-9	2015	This study confirmed that SPI exhibited a high capacity to load water-insoluble curcumin, and an ultrasonic pretreatment could further improve its encapsulation efficiency and stability of curcumin.	Water	64-69	chromogranin A	Homo sapiens	26-29
26116387-2	2015	Catalase, an important antioxidant enzyme, catalyzing decomposition of hydrogen peroxide to water and molecular oxygen, hampers in vitro HOCl formation, but is also one of the main targets for HOCl.	Water	92-97	catalase	Homo sapiens	0-8
26717689-8	2015	Cl-DBPFP in OCC outlet water were lower than those in PC because oxidized destruction of DBP precursors were enhanced by catalyzed ozonation by AlCl3 along with its other hydrolyzed species.	Water	23-28	D-box binding PAR bZIP transcription factor	Homo sapiens	3-6
26717689-18	2015	Coagulation results and DBP formations are significantly affected by interaction of ozonation and coagulation; and it should be a noticeable point of water safety if ozonation and coagulation are employed together.	Water	150-155	D-box binding PAR bZIP transcription factor	Homo sapiens	24-27
26178576-6	2015	PBEF also inhibited the expression of aquaporin 1 (AQP1), which caused a dysfunction and imbalance in water transport.	Water	102-107	aquaporin 1 (Colton blood group)	Homo sapiens	38-49
26178576-6	2015	PBEF also inhibited the expression of aquaporin 1 (AQP1), which caused a dysfunction and imbalance in water transport.	Water	102-107	aquaporin 1 (Colton blood group)	Homo sapiens	51-55
26178576-9	2015	Taken together, these results demonstrate that the increase in intracellular PBEF expression promoted the apoptosis of HPMECs and the expression of inflammatory factors and thus enhanced the inflammatory response and inhibited the expression of AQP1, which resulted in abnormal water transport, diminishing the regulatory effects of AQP1 on water transport.	Water	278-283	aquaporin 1 (Colton blood group)	Homo sapiens	245-249
26231989-2	2015	In this study, we (1) classified potential NO3(-) pollution activities via an unsupervised learning algorithm based on delta(15)N- and delta(18)O-NO3(-) and physico-chemical properties of groundwater at 55 sampling locations; and (2) determined which water quality parameters could be used to identify the sources of NO3(-) contamination via a decision tree model.	Water	194-199	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
26284350-0	2015	Use of Actuator-Driven Pulsed Water Jet in Brain and Spinal Cord Cavernous Malformations Resection.	Water	30-35	F-box and leucine rich repeat protein 15	Homo sapiens	36-39
26001490-14	2015	CAD/CAM interim restorations demonstrated significantly lower water sorption, higher wear resistance, higher surface hardness, and significantly higher fracture resistance (1289+-56N) compared with manually fabricated interim restorations (AP=996 +-45, AM=899 +-37, and TP=1179 +-41).	Water	62-67	calmodulin 3	Homo sapiens	4-7
26121313-17	2015	Altogether PGE2 acting on EP1 and EP4 receptors may prove to be important mediators of PT injury, and salt and water transport.	Water	111-116	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	26-29
26108786-12	2015	RVI requires the sequential activation of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and NKCC1, a Na(+) -K(+) -Cl(-) cotransporter, allowing ion entry and driving osmotic water flow.	Water	182-187	serine/threonine kinase 39	Homo sapiens	90-94
26284350-1	2015	BACKGROUND: A piezo actuator-driven pulsed water jet (ADPJ) system is a novel surgical instrument that enables dissection of tissue without thermal damage.	Water	43-48	F-box and leucine rich repeat protein 15	Homo sapiens	49-52
26284350-8	2015	The pulsed water jet provided a clear surgical view and helped surgeons follow the margins.	Water	11-16	F-box and leucine rich repeat protein 15	Homo sapiens	17-20
26284350-9	2015	Water jet dissection peeled off the brain and spinal cord tissues from the lesion wall.	Water	0-5	F-box and leucine rich repeat protein 15	Homo sapiens	6-9
25599980-0	2015	Transcription co-activator Arabidopsis ANGUSTIFOLIA3 (AN3) regulates water-use efficiency and drought tolerance by modulating stomatal density and improving root architecture by the transrepression of YODA (YDA).	Water	69-74	SSXT family protein	Arabidopsis thaliana	54-57
25339224-0	2015	Glucocorticoids stimulate endolymphatic water reabsorption in inner ear through aquaporin 3 regulation.	Water	40-45	aquaporin 3	Mus musculus	80-91
25339224-2	2015	Since dysregulation of water transport could account for the generation of this hydrops, we investigated the role of aquaporin 3 (AQP3) in water transport into endolymph, the K-rich, hyperosmotic fluid that bathes the apical ciliated membrane of sensory cells, and we studied the regulatory effect of dexamethasone upon AQP3 expression and water fluxes.	Water	139-144	aquaporin 3	Mus musculus	117-128
25339224-2	2015	Since dysregulation of water transport could account for the generation of this hydrops, we investigated the role of aquaporin 3 (AQP3) in water transport into endolymph, the K-rich, hyperosmotic fluid that bathes the apical ciliated membrane of sensory cells, and we studied the regulatory effect of dexamethasone upon AQP3 expression and water fluxes.	Water	139-144	aquaporin 3	Mus musculus	130-134
25339224-2	2015	Since dysregulation of water transport could account for the generation of this hydrops, we investigated the role of aquaporin 3 (AQP3) in water transport into endolymph, the K-rich, hyperosmotic fluid that bathes the apical ciliated membrane of sensory cells, and we studied the regulatory effect of dexamethasone upon AQP3 expression and water fluxes.	Water	139-144	aquaporin 3	Mus musculus	117-128
25339224-2	2015	Since dysregulation of water transport could account for the generation of this hydrops, we investigated the role of aquaporin 3 (AQP3) in water transport into endolymph, the K-rich, hyperosmotic fluid that bathes the apical ciliated membrane of sensory cells, and we studied the regulatory effect of dexamethasone upon AQP3 expression and water fluxes.	Water	139-144	aquaporin 3	Mus musculus	130-134
26000467-6	2015	Pyrabactin-mediated water transport and ZmPIP gene expression were phosphorylation-dependent, suggesting that ABA-PYR1-(PP2C)-protein kinase-AQP signaling pathway may be involved in this process.	Water	20-25	Polyketide cyclase/dehydrase and lipid transport superfamily protein	Arabidopsis thaliana	114-118
25599980-0	2015	Transcription co-activator Arabidopsis ANGUSTIFOLIA3 (AN3) regulates water-use efficiency and drought tolerance by modulating stomatal density and improving root architecture by the transrepression of YODA (YDA).	Water	69-74	SSXT family protein	Arabidopsis thaliana	39-52
25917777-7	2015	Estrogen and androgen receptor activities of surface water samples were predictive of wastewater input, although the lower sensitivity of the ethinylestradiol ELISA relative to the very high sensitivity of the bioassay approaches did not allow a direct comparison.	Water	53-58	androgen receptor	Homo sapiens	13-30
26591779-22	2015	12 microg/g) in pure water group was lower than that of filtered tap-water group 45.	Water	69-74	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	65-68
26591779-31	2015	CONCLUSIONN: Long-term drinking filtered tap-water is beneficial to the glomerular filtration barrier, and it may be related to the increase of zinc levels in kidney.	Water	45-50	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	41-44
26183290-2	2015	In this study, using a water-soluble carboxylated aniline trimer derivative (CAT(-)) as a stabilizer, the commercial graphene can be stably dispersed in water at high concentration (&gt;1 mg/mL) via strong pi-pi interaction that was proved by Raman and UV-vis spectra.	Water	23-28	catalase	Homo sapiens	77-80
26183290-2	2015	In this study, using a water-soluble carboxylated aniline trimer derivative (CAT(-)) as a stabilizer, the commercial graphene can be stably dispersed in water at high concentration (&gt;1 mg/mL) via strong pi-pi interaction that was proved by Raman and UV-vis spectra.	Water	153-158	catalase	Homo sapiens	77-80
26041443-4	2015	The antinatriuretic effects of AVP are mediated by the regulation of sodium transport throughout the distal nephron, from the thick ascending limb through to the collecting duct, which in turn partially facilitates osmotic movement of water.	Water	235-240	arginine vasopressin	Homo sapiens	31-34
25827271-0	2015	Characterization and photocatalytic treatability of red water from Brazilian TNT industry.	Water	56-61	chromosome 16 open reading frame 82	Homo sapiens	77-80
25827271-1	2015	The current study aims to characterize and evaluate the photocatalytic treatability of the "red water" effluent from a Brazilian TNT production industry.	Water	96-101	chromosome 16 open reading frame 82	Homo sapiens	129-132
26214368-1	2015	Rates of SN1 hydrolysis reactions for 2-chloro-2-methylbutane in the critical solution of isobutyric acid + water and for 2-bromo-2-methylpropane in the critical solution of triethylamine + water in the one-phase region and at various temperatures have been determined respectively by conductance measurements.	Water	108-113	solute carrier family 38 member 3	Homo sapiens	9-12
26214368-1	2015	Rates of SN1 hydrolysis reactions for 2-chloro-2-methylbutane in the critical solution of isobutyric acid + water and for 2-bromo-2-methylpropane in the critical solution of triethylamine + water in the one-phase region and at various temperatures have been determined respectively by conductance measurements.	Water	190-195	solute carrier family 38 member 3	Homo sapiens	9-12
26203893-8	2015	The SOS@ZnO microspheres show excellent photocatalytic activity, as measured by degradation of methyl orange in water, when compared to ZnO nanoparticles.	Water	112-117	xylosyltransferase 2	Homo sapiens	4-7
26196462-2	2015	A notable feature of this enzyme complex is that it uses menaquinol as its electron donor instead of cytochrome c when it reduces dioxygen to water.	Water	142-147	cytochrome c, somatic	Homo sapiens	101-113
26273831-10	2015	The present study demonstrates the technical feasibility of using the improved CES process to encapsulate water-soluble drugs at a high concentration for sustained release of anti-VEGF therapy.	Water	106-111	vascular endothelial growth factor A	Homo sapiens	180-184
26273320-11	2015	CONCLUSIONS: The PRO-MEC system holds great promise in addressing water-energy nexus through organic removal, hydrogen production, and water recovery: (1) the PRO unit can reduce the volume of wastewater and extract clean water; (2) the PRO effluents can be further treated by the MEC; and (3) the osmotic energy harvested from the PRO unit can be applied to the MEC for sustainable bioelectrochemical hydrogen production.	Water	66-71	C-C motif chemokine ligand 28	Homo sapiens	21-24
26273320-11	2015	CONCLUSIONS: The PRO-MEC system holds great promise in addressing water-energy nexus through organic removal, hydrogen production, and water recovery: (1) the PRO unit can reduce the volume of wastewater and extract clean water; (2) the PRO effluents can be further treated by the MEC; and (3) the osmotic energy harvested from the PRO unit can be applied to the MEC for sustainable bioelectrochemical hydrogen production.	Water	66-71	C-C motif chemokine ligand 28	Homo sapiens	281-284
26273320-11	2015	CONCLUSIONS: The PRO-MEC system holds great promise in addressing water-energy nexus through organic removal, hydrogen production, and water recovery: (1) the PRO unit can reduce the volume of wastewater and extract clean water; (2) the PRO effluents can be further treated by the MEC; and (3) the osmotic energy harvested from the PRO unit can be applied to the MEC for sustainable bioelectrochemical hydrogen production.	Water	66-71	C-C motif chemokine ligand 28	Homo sapiens	281-284
26273320-11	2015	CONCLUSIONS: The PRO-MEC system holds great promise in addressing water-energy nexus through organic removal, hydrogen production, and water recovery: (1) the PRO unit can reduce the volume of wastewater and extract clean water; (2) the PRO effluents can be further treated by the MEC; and (3) the osmotic energy harvested from the PRO unit can be applied to the MEC for sustainable bioelectrochemical hydrogen production.	Water	135-140	C-C motif chemokine ligand 28	Homo sapiens	21-24
26277145-0	2015	Homogeneous SPC/E water nucleation in large molecular dynamics simulations.	Water	18-23	proline rich protein gene cluster	Homo sapiens	12-15
26274523-3	2015	Here we describe a rapid cell-free and detergent-free co-translation method for producing full-length and functional ERBB2 and EGFR receptor tyrosine kinases supported by water-soluble apolipoprotein A-I based nanolipoprotein particles.	Water	171-176	erb-b2 receptor tyrosine kinase 2	Homo sapiens	117-122
26274523-3	2015	Here we describe a rapid cell-free and detergent-free co-translation method for producing full-length and functional ERBB2 and EGFR receptor tyrosine kinases supported by water-soluble apolipoprotein A-I based nanolipoprotein particles.	Water	171-176	epidermal growth factor receptor	Homo sapiens	127-131
26274523-3	2015	Here we describe a rapid cell-free and detergent-free co-translation method for producing full-length and functional ERBB2 and EGFR receptor tyrosine kinases supported by water-soluble apolipoprotein A-I based nanolipoprotein particles.	Water	171-176	apolipoprotein A1	Homo sapiens	185-203
26274605-7	2015	The rate constants for BDE-47 and BDE-28 (9.01 and 17.52 x 10-3 min-1), added to isopropyl alcohol, were very close to those (9.65 and 18.42 x 10-3 min-1) in water, proving the less indirect photolytic contribution of  OH in water.	Water	158-163	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
26274605-7	2015	The rate constants for BDE-47 and BDE-28 (9.01 and 17.52 x 10-3 min-1), added to isopropyl alcohol, were very close to those (9.65 and 18.42 x 10-3 min-1) in water, proving the less indirect photolytic contribution of  OH in water.	Water	158-163	CD59 molecule (CD59 blood group)	Homo sapiens	148-153
26274605-7	2015	The rate constants for BDE-47 and BDE-28 (9.01 and 17.52 x 10-3 min-1), added to isopropyl alcohol, were very close to those (9.65 and 18.42 x 10-3 min-1) in water, proving the less indirect photolytic contribution of  OH in water.	Water	225-230	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
26274605-7	2015	The rate constants for BDE-47 and BDE-28 (9.01 and 17.52 x 10-3 min-1), added to isopropyl alcohol, were very close to those (9.65 and 18.42 x 10-3 min-1) in water, proving the less indirect photolytic contribution of  OH in water.	Water	225-230	CD59 molecule (CD59 blood group)	Homo sapiens	148-153
25957792-9	2015	The pretreatment of OVX(+)/HSD rats with the MR antagonist eplerenone reduced brain water-free Na(+) accumulation, up-regulated ATP1alpha3, down-regulated MR, and reduced the cortical infarct volume.	Water	84-89	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	45-47
26102216-6	2015	Our results show that the water extract from red vine leaves inhibits TNFalpha-induced IL-8 secretion and expression in human gastric epithelial cells; the effect should be maintained, although to a lesser extent, after gastric digestion.	Water	26-31	tumor necrosis factor	Homo sapiens	70-78
26168359-3	2015	A brominated DBP with a relative abundance of almost 22% was identified as 2,2,4-tribromo-5-hydroxy-4-cyclopentene-1,3-dione, which is an analogue to several previously described 2,2,4-trihalo-5-hydroxy-4-cyclopentene-1,3-diones in drinking water.	Water	241-246	D-box binding PAR bZIP transcription factor	Homo sapiens	13-16
25821088-0	2015	Prevalence and characteristics of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae isolated from rural well water in Taian, China, 2014.	Water	128-133	EsbL	Escherichia coli	34-66
26073546-2	2015	Water solubility of curcumin in curcumin-Eudragit  E PO solid dispersion (Cur@EPO) was greatly increased.	Water	0-5	erythropoietin	Homo sapiens	74-81
26338870-4	2015	Using the antibodies that specifically recognize previously characterized AQPs, two water-specific subtypes-AQP-Bom1 and AQP-Bom3-belonging to the Drosophila integral protein (DRIP) and Pyrocoelia rufa integral protein (PRIP) subfamilies of the insect AQP clade, respectively, were identified in the developing ovaries of B. mori.	Water	84-89	aquaporin	Drosophila melanogaster	74-77
26338870-4	2015	Using the antibodies that specifically recognize previously characterized AQPs, two water-specific subtypes-AQP-Bom1 and AQP-Bom3-belonging to the Drosophila integral protein (DRIP) and Pyrocoelia rufa integral protein (PRIP) subfamilies of the insect AQP clade, respectively, were identified in the developing ovaries of B. mori.	Water	84-89	aquaporin	Drosophila melanogaster	108-111
26338870-4	2015	Using the antibodies that specifically recognize previously characterized AQPs, two water-specific subtypes-AQP-Bom1 and AQP-Bom3-belonging to the Drosophila integral protein (DRIP) and Pyrocoelia rufa integral protein (PRIP) subfamilies of the insect AQP clade, respectively, were identified in the developing ovaries of B. mori.	Water	84-89	aquaporin	Drosophila melanogaster	108-111
26388582-4	2015	The possibility of renal secretion of hyaluronidase into the blood as a mechanism of antidiuretic activity of vasopressin and its role in the regulation of water metabolism are discussed.	Water	156-161	arginine vasopressin	Rattus norvegicus	110-121
25916185-4	2015	In covariate-adjusted models, a 10% increase in water As, urinary As adjusted for specific gravity (uAs), or blood As (bAs) was associated with a 0.74% (p = 0.01), 0.90% (p = 0.16), and 1.39% (p = 0.07) increase in CRP, respectively; there was no association with AGP.	Water	48-53	C-reactive protein	Homo sapiens	215-218
28411979-0	2015	Peroxidase (POD) and polyphenol oxidase (PPO) photo-inactivation in a coconut water model solution using ultraviolet (UV).	Water	78-83	protoporphyrinogen oxidase	Homo sapiens	41-44
26102216-6	2015	Our results show that the water extract from red vine leaves inhibits TNFalpha-induced IL-8 secretion and expression in human gastric epithelial cells; the effect should be maintained, although to a lesser extent, after gastric digestion.	Water	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
26102216-8	2015	The main molecular target of VVWE at the gastric level includes TNFalpha-induced activation of NF-kappaB and occurs at concentrations easily reachable after PFS consumption based on red vine leaf water extract as the ingredient.	Water	196-201	tumor necrosis factor	Homo sapiens	64-72
26102216-9	2015	Our findings suggest that PFS containing water extracts from Vitis vinifera L. leaves could be useful to inhibit/attenuate gastric inflammation inhibiting IL-8 secretion and expression through impairment of the NF-kappaB pathway.	Water	41-46	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
26168295-3	2015	Here we describe GE-137, a water-soluble probe consisting of a 26-amino acid cyclic peptide that binds the human tyrosine kinase c-Met conjugated to a fluorescent cyanine dye.	Water	27-32	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	129-134
26592006-4	2015	The percentages of various N species showed that NO3- -N was the major N species in the Yangtze River and Wangyu River during the 2 water transfer processes.	Water	132-137	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
26101342-5	2015	Angiotensin II+vehicle rats had increased mean blood pressure, increased sympathetic drive as indicated by the mean blood pressure response to ganglionic blockade, and increased water consumption.	Water	178-183	angiotensinogen	Rattus norvegicus	0-14
26101342-8	2015	The plasma vasopressin response to a 6-hour water restriction also increased.	Water	44-49	arginine vasopressin	Rattus norvegicus	11-22
26058692-8	2015	We concluded that increased plasma glucose and insulin levels can cause the appearance of the AD-like pattern in both (18)F-FDG and (15)O-H2O images, and this phenomenon can occur even in subjects without insulin resistance.	Water	138-141	insulin	Homo sapiens	47-54
25993324-0	2015	Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.	Water	34-39	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	100-104
26075674-11	2015	Our study suggests that the presence of AQP 1, 3, and 5 in the middle ear cavity may be to have an important role for water transportation.	Water	118-123	aquaporin 1 (Colton blood group)	Homo sapiens	40-45
26107592-6	2015	An EDC-mediated procedure with ~5 mM EDC and NHS (1:1) made in water, with a full acid monolayer, with 250 muM aminoferrocene for 40 min was found to give the highest ferrocene attachment.	Water	63-68	latexin	Homo sapiens	107-110
26279619-3	2015	Aquaporin-1 (AQP1) and aquaporin-4 (AQP4) are water transport proteins that are highly expressed in primary glial-derived tumors.	Water	46-51	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
26279619-3	2015	Aquaporin-1 (AQP1) and aquaporin-4 (AQP4) are water transport proteins that are highly expressed in primary glial-derived tumors.	Water	46-51	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
26111991-1	2015	Ultrafast fluorescence dynamics of Tryptophan-Tryptophan (Trp-Trp/Trp2) dipeptide and its derivatives in water have been investigated using a picosecond resolved time correlated single photon counting (TCSPC) apparatus together with a femtosecond resolved upconversion spectrophotofluorometer.	Water	105-110	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	66-70
26111991-4	2015	Due to the intramolecular interaction between two Trp residues, the "water relaxation" lifetime was observed around 4ps, and it is noticed that Trp2 and its derivatives also exhibit a new decay with a lifetime of ~100ps, while single-Trp fluorescence decay in dipeptides/proteins shows 20-30ps.	Water	69-74	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	144-148
26045060-1	2015	INTRODUCTION: The aquaporins (AQP1, 3, 8, 9 and 11) are known to be expressed, and involved in the transport of water and small molecules through fetal membranes.	Water	112-117	aquaporin 1 (Colton blood group)	Homo sapiens	30-50
26233143-15	2015	B 112, 9020 (2008)] were used along with the extended simple point charge (SPC/E) water model [Berendsen et al., J. Phys.	Water	82-87	proline rich protein gene cluster	Homo sapiens	75-78
26218429-0	2015	Opposing Effects of cAMP and T259 Phosphorylation on Plasma Membrane Diffusion of the Water Channel Aquaporin-5 in Madin-Darby Canine Kidney Cells.	Water	86-91	cathelicidin antimicrobial peptide	Canis lupus familiaris	20-24
26218429-0	2015	Opposing Effects of cAMP and T259 Phosphorylation on Plasma Membrane Diffusion of the Water Channel Aquaporin-5 in Madin-Darby Canine Kidney Cells.	Water	86-91	aquaporin 5	Canis lupus familiaris	100-111
26218429-1	2015	Aquaporin-5 (AQP5) facilitates passive water transport in glandular epithelia in response to secretory stimuli via intracellular pathways involving calcium release, cAMP and protein kinase A (PKA).	Water	39-44	aquaporin 5	Canis lupus familiaris	0-11
26218429-1	2015	Aquaporin-5 (AQP5) facilitates passive water transport in glandular epithelia in response to secretory stimuli via intracellular pathways involving calcium release, cAMP and protein kinase A (PKA).	Water	39-44	aquaporin 5	Canis lupus familiaris	13-17
26218429-1	2015	Aquaporin-5 (AQP5) facilitates passive water transport in glandular epithelia in response to secretory stimuli via intracellular pathways involving calcium release, cAMP and protein kinase A (PKA).	Water	39-44	cathelicidin antimicrobial peptide	Canis lupus familiaris	165-169
26218429-2	2015	In epithelial plasma membranes, AQP5 may be acutely regulated to facilitate water transport in response to physiological stimuli by changes in protein modifications, interactions with proteins and lipids, nanoscale membrane domain organization, and turnover rates.	Water	76-81	aquaporin 5	Canis lupus familiaris	32-36
26218429-6	2015	Thus, lateral diffusion of AQP5 is significantly regulated by cAMP, PKA, and T259 phosphorylation, which could be important for regulating water flow in glandular secretions.	Water	139-144	aquaporin 5	Canis lupus familiaris	27-31
26218429-6	2015	Thus, lateral diffusion of AQP5 is significantly regulated by cAMP, PKA, and T259 phosphorylation, which could be important for regulating water flow in glandular secretions.	Water	139-144	cathelicidin antimicrobial peptide	Canis lupus familiaris	62-66
26115405-3	2015	For molecular dynamics simulations of the binary solvent, we have modified a TraPPE-UA model for tetrahydrofuran and combined it with the SPC/E potential for water.	Water	158-163	proline rich protein gene cluster	Homo sapiens	138-141
25723768-2	2015	The bio-bar-coded Pt nanoparticles (NPs)/G-quadruplex/hemin exhibited high CAT-like activity following the Michaelis-Menten model for decomposing H2O2 to water and oxygen, whose activity even slightly exceeded that of natural CAT.	Water	154-159	catalase	Homo sapiens	75-78
25723768-2	2015	The bio-bar-coded Pt nanoparticles (NPs)/G-quadruplex/hemin exhibited high CAT-like activity following the Michaelis-Menten model for decomposing H2O2 to water and oxygen, whose activity even slightly exceeded that of natural CAT.	Water	154-159	catalase	Homo sapiens	226-229
26178088-6	2015	The applicability of this approach is demonstrated for the embedded many-body expansion of binding energies of water hexamers and calculation of reaction barriers of SN2 substitution of fluorine by chlorine in alpha-fluoroalkanes.	Water	111-116	solute carrier family 38 member 5	Homo sapiens	166-169
25960294-3	2015	Aquaporin 0 (AQP0), which constitutes ~45% of the total membrane proteins of lens fiber cells, has been shown to function as a water channel and a structural cell-to-cell adhesion (CTCA) protein.	Water	127-132	major intrinsic protein of lens fiber	Mus musculus	0-11
25960294-3	2015	Aquaporin 0 (AQP0), which constitutes ~45% of the total membrane proteins of lens fiber cells, has been shown to function as a water channel and a structural cell-to-cell adhesion (CTCA) protein.	Water	127-132	major intrinsic protein of lens fiber	Mus musculus	13-17
26061185-4	2015	Our results indicate that CONUS water bodies sequester 20.8 (95% CI: 9.4-65.8) Tg C yr(-1), and spatial patterns in OC burial are strongly influenced by water body type, size, and abundance; land use; and soil and vegetation characteristics in surrounding areas.	Water	32-37	transglutaminase 2	Homo sapiens	79-83
25994586-5	2015	Mean-field calculations on hydrated electrons (H2O)n(-) show that the density-matrix-based EDR reproduces existing molecular-orbital-based measures of delocalization.	Water	47-50	paternally expressed 10	Homo sapiens	91-94
26345741-10	2015	The results suggested that TGF-beta1 rs1800469 TT and rs2241715 TT homozygote genotypes represent the genetic factors underlying familial clustering of liver cancer in Guangxi, and that drinking water use, alcohol consumption, and testing positive for HBV DNA are the main environmental factors contributing to familial aggregation of liver cancer in Guangxi.	Water	195-200	transforming growth factor beta 1	Homo sapiens	27-36
26084357-1	2015	A water-soluble pi-conjugated bispyridinium phenylenevinylene-based fluorogenic probe has been developed as a novel fluorescent chemosensor for highly selective, sensitive, and rapid detection of NO3(-) anion in acidic aqueous media.	Water	2-7	NBL1, DAN family BMP antagonist	Homo sapiens	196-199
27092011-3	2015	The findings hint that the air-water interface is a locale for synthetic reactions.	Water	31-36	histidine triad nucleotide binding protein 1	Homo sapiens	13-17
26186212-9	2015	These results suggest that differences in tumorigenesis among CPC;Apc mice consuming chlorinated versus tap water may be due to differences in gastrointestinal commensal populations.	Water	108-113	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	104-107
26159541-6	2015	METHODS: We applied an extended multilevel approach to a large cross-sectional study aimed to elucidate the hypothesized link between drinking water pollution from perfluoroctanoic acid (PFOA) and plasma levels of C-reactive protein (CRP) or lymphocyte counts.	Water	143-148	C-reactive protein	Homo sapiens	214-232
26159541-6	2015	METHODS: We applied an extended multilevel approach to a large cross-sectional study aimed to elucidate the hypothesized link between drinking water pollution from perfluoroctanoic acid (PFOA) and plasma levels of C-reactive protein (CRP) or lymphocyte counts.	Water	143-148	C-reactive protein	Homo sapiens	234-237
26041430-9	2015	The chromatographic performance of multiple EPGs containing C18 HILIC phases is illustrated by the separation of sulfa drugs, beta-blockers, xanthines, nucleic acid bases, nucleosides, and water-soluble vitamins.	Water	189-194	Bardet-Biedl syndrome 9	Homo sapiens	60-63
25731750-4	2015	Here we describe the conformations and ligand binding activities of water-soluble and membrane-bound BCL-XL, with its complete C-terminus, in detergent-free environments.	Water	68-73	BCL2 like 1	Homo sapiens	101-107
26153706-1	2015	The hydrophobic surfactant proteins SP-B and SP-C greatly accelerate the adsorption of vesicles containing the surfactant lipids to form a film that lowers the surface tension of the air/water interface in the lungs.	Water	187-192	surfactant protein C	Homo sapiens	45-49
26090963-0	2015	Characterization of Water Coordination to Ferrous Nitrosyl Complexes with fac-N2O, cis-N2O2, and N2O3 Donor Ligands.	Water	20-25	FA complementation group C	Homo sapiens	74-77
26090963-2	2015	These complexes formed a comparative family, {FeNO}(7)(N2Ox)(H2O)3-x with x = 1-3, where the labile coordination sites for the binding of NO and solvent water were fac for x = 1 and cis for x = 2.	Water	153-158	FA complementation group C	Homo sapiens	164-167
25925260-12	2015	Altogether, glucagon, vasopressin, and urea contribute to set up the best compromise between efficient urea excretion and water economy.	Water	122-127	arginine vasopressin	Homo sapiens	22-33
26962591-9	2015	The drug works by prolonging the time that activated CFTR channels remain open, thereby enhancing the regulation of chloride and water transport across cell membranes.	Water	129-134	CF transmembrane conductance regulator	Homo sapiens	53-57
25752635-7	2015	Water parameters (as TP, TN, SS, and SPC) decreased by about 90 %.	Water	0-5	proline rich protein gene cluster	Homo sapiens	37-40
25995108-6	2015	During both normal water intake and mild water restriction, PRR KO mice had significantly lower urine osmolality, higher water intake, and higher urine volume compared with control mice.	Water	19-24	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	60-63
25995108-6	2015	During both normal water intake and mild water restriction, PRR KO mice had significantly lower urine osmolality, higher water intake, and higher urine volume compared with control mice.	Water	41-46	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	60-63
25995108-6	2015	During both normal water intake and mild water restriction, PRR KO mice had significantly lower urine osmolality, higher water intake, and higher urine volume compared with control mice.	Water	41-46	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	60-63
25759212-7	2015	The significant gene-environment interaction between a SNP in the INPP5A gene (rs1133400) and water arsenic with respect to the skin lesion risk was successfully replicated in an independent population (P for interaction = .03).	Water	94-99	inositol polyphosphate-5-phosphatase A	Homo sapiens	66-72
26717727-0	2015	[The Characteristic Research of  OH Induced by Water on an Argon Plasma Jet].	Water	47-52	F-box and leucine rich repeat protein 15	Homo sapiens	72-75
26717727-6	2015	Thus, a device of argon plasma jet with a Ring-to-Ring Electrode Configuration has been designed to interact with water in the surrounding air to generate  OH under atmospheric pressure.	Water	114-119	F-box and leucine rich repeat protein 15	Homo sapiens	31-34
26717749-11	2015	Then it makes that the slop of Raman shift and the full width at half maximum in the CS2 solution are faster than dissolved in water with increasing pressure.	Water	127-132	chorionic somatomammotropin hormone 2	Homo sapiens	85-88
26339342-2	2015	Ethyl pyruvate (EP) is a cytoprotective agent, while aquaporin-8 (AQP8) is a mitochondrial water channel that can induce mitochondrial swelling.	Water	91-96	aquaporin 8	Rattus norvegicus	53-64
26489311-3	2015	The results showed that DBP migrated from the soil to the overlying water in the early days after flooding, and the release process of DBP was divided into two phases: one was quick release with a relatively short releasing time and a rapid releasing rate; the other was slow release with a relatively long releasing time and a slow releasing rate.	Water	68-73	D-box binding PAR bZIP transcription factor	Homo sapiens	24-27
26489311-7	2015	The water conditions of overlying water could impact the migration and releasing process of DBP when the soil in fluctuating zone was flooded.	Water	4-9	D-box binding PAR bZIP transcription factor	Homo sapiens	92-95
26489311-7	2015	The water conditions of overlying water could impact the migration and releasing process of DBP when the soil in fluctuating zone was flooded.	Water	34-39	D-box binding PAR bZIP transcription factor	Homo sapiens	92-95
26489311-8	2015	The amount of DBP released into the overlying water would increase when the ionic strength in the water increased.	Water	46-51	D-box binding PAR bZIP transcription factor	Homo sapiens	14-17
26489311-8	2015	The amount of DBP released into the overlying water would increase when the ionic strength in the water increased.	Water	98-103	D-box binding PAR bZIP transcription factor	Homo sapiens	14-17
26489311-10	2015	The higher concentration of organic matter in overlying water, the more the amount of DBP released into the overlying water.	Water	56-61	D-box binding PAR bZIP transcription factor	Homo sapiens	86-89
26489311-10	2015	The higher concentration of organic matter in overlying water, the more the amount of DBP released into the overlying water.	Water	118-123	D-box binding PAR bZIP transcription factor	Homo sapiens	86-89
26339342-2	2015	Ethyl pyruvate (EP) is a cytoprotective agent, while aquaporin-8 (AQP8) is a mitochondrial water channel that can induce mitochondrial swelling.	Water	91-96	aquaporin 8	Rattus norvegicus	66-70
25977473-6	2015	Our data demonstrate that the activation of CaSR in the collecting duct prevents the cAMP-dependent increase in AQP2-pS256 and water permeability, counteracting the short-term vasopressin response.	Water	127-132	calcium sensing receptor	Homo sapiens	44-48
25534595-7	2015	Moreover, analysis of fluorescence micrographs, which were obtained from the MSHTS system, revealed that the morphology of the Abeta aggregates coincubated with boiling water extracts differed from control aggregates, suggesting that the MSHTS system is also useful for screening substances that affect the morphology of aggregates.	Water	169-174	amyloid beta precursor protein	Homo sapiens	127-132
24106070-4	2015	Thus, water intoxication with subsequent hyponatremia, although rare, is a potentially serious side effect of exogenous vasopressin administration.	Water	6-11	arginine vasopressin	Homo sapiens	120-131
25736430-9	2015	It suggests that the PEO remains anchored in a metastable state at the air-water interface at surface concentration well above the onset of the plateau.	Water	75-80	twinkle mtDNA helicase	Homo sapiens	21-24
26163575-6	2015	OST1 enhanced PIP2;1 water transport activity when coexpressed in Xenopus laevis oocytes.	Water	21-26	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	14-20
25645193-0	2015	Danshen (Salvia miltiorrhiza) water extract inhibits paracetamol-induced toxicity in primary rat hepatocytes via reducing CYP2E1 activity and oxidative stress.	Water	30-35	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	122-128
25645193-1	2015	OBJECTIVES: This study aimed to investigate the protective effects of Danshen (Salvia miltiorrhiza) water extract (DSE) and its major phenolic acid components against CYP2E1-mediated paracetamol (APAP)-induced hepatic toxicity.	Water	100-105	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	167-173
26002002-5	2015	Contact lens materials that have high ionicity and high water content have an increased affinity to accumulate lysozyme during wear, when compared with other soft lens materials, notably silicone hydrogel lenses.	Water	56-61	lysozyme	Homo sapiens	111-119
25263537-4	2015	ahk3-3 mutants had increased root elongation after transfer to low water potential media.	Water	67-72	histidine kinase 3	Arabidopsis thaliana	0-4
25022529-7	2015	The administration of an AVP-V2 receptor inhibitor or the consumption of sufficient water to persistently lower plasma AVP levels will ameliorate disease progression.	Water	84-89	arginine vasopressin	Homo sapiens	119-122
26163575-8	2015	This work supports a model whereby ABA-triggered stomatal closure requires an increase in guard cell permeability to water and possibly hydrogen peroxide, through OST1-dependent phosphorylation of PIP2;1 at Ser-121.	Water	117-122	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	197-203
25998829-3	2015	Furthermore, replacing the -Cl substituent with -Br on the HL-X ligand will also afford three diverse coordination assemblies of 3D {[Zn2(L-Br)4(H2O)](CH3OH)2.5}n (5), mononuclear [Zn(HL-Br)2(H2O)4][L-Br]2 (6), and 2D {[Zn(L-Br)2](H2O)1.15}n (7) depending on the synthetic pathways.	Water	145-148	H2.0 like homeobox	Homo sapiens	59-63
25813965-3	2015	The composition of groundwater corresponds mainly to low mineralized Na-HCO3 to Na-Cl water types, the latter dominant in Santa Maria island, with a decreasing order of Na&gt;Ca&gt;Mg&gt;K and Cl&gt;HCO3&gt;SO4&gt;NO3 for cations and anion respectively.	Water	25-30	NBL1, DAN family BMP antagonist	Homo sapiens	214-217
26122204-0	2015	Water extract of brewers" rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/beta-catenin downstream signaling pathway in brewers" rice-treated rats with azoxymethane-induced colon carcinogenesis.	Water	0-5	caspase 3	Homo sapiens	100-109
26013592-6	2015	Irrespective of the lignin pretreatment, both HTc-Cu-V and V(acac)3 /Cu(NO3 )2  3 H2 O were able to cleave the beta-O-4 linkages and the resinol structures to form dimeric and trimeric products.	Water	82-86	NBL1, DAN family BMP antagonist	Homo sapiens	69-75
26133429-3	2015	The SN2 reaction dominates at all reactant collision energies, but at higher collision energies proton transfer to form CH2I(-), and to a lesser extent CH2I(-) (H2O), becomes important.	Water	161-164	solute carrier family 38 member 5	Homo sapiens	4-7
26133429-7	2015	Overall, the simulation results for the OH(-)(H2O) + CH3I SN2 reaction are in good agreement with experiment with respect to reaction rate constant, product branching ratio, etc.	Water	46-50	solute carrier family 38 member 5	Homo sapiens	58-61
26133429-10	2015	The SN2 reaction is dominated by events in which H2O leaves the reactive system as CH3OH is formed or before CH3OH formation.	Water	49-52	solute carrier family 38 member 5	Homo sapiens	4-7
26024204-0	2015	HYSCORE Analysis of the Effects of Substrates on Coordination of Water to the Active Site Iron in Tyrosine Hydroxylase.	Water	65-70	tyrosine hydroxylase	Homo sapiens	98-118
26088017-7	2015	Reactions with various electron scavengers including H(+), NO2(-), NO3(-) and H2O2 show that the kinetics are similar, but not identical, to those for solvated electrons formed in bulk water by radiolysis.	Water	185-190	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
25948814-6	2015	However, after drinking dextran sodium sulfate-containing water, TIPE-deficient mice developed more severe colitis than wild type mice did, as demonstrated by decreased survival rates, increased body weight loss, and enhanced leukocyte infiltration, bacterial invasion, and inflammatory cytokine production in the colon.	Water	58-63	tumor necrosis factor, alpha-induced protein 8	Mus musculus	65-69
25791254-0	2015	Detection of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in vegetables, soil and water of the farm environment in Tunisia.	Water	106-111	EsbL	Escherichia coli	47-51
25791254-3	2015	ESBL-producing Enterobacteriaceae (ESBL-Eb) were detected in 10 of the 109 farm samples (vegetables, 8.2%; soil, 7.3%; water, 15.8%), and in 4 of 45 vegetables of markets (8.9%), recovering 15 ESBL-Eb.	Water	119-124	EsbL	Escherichia coli	0-4
25791254-3	2015	ESBL-producing Enterobacteriaceae (ESBL-Eb) were detected in 10 of the 109 farm samples (vegetables, 8.2%; soil, 7.3%; water, 15.8%), and in 4 of 45 vegetables of markets (8.9%), recovering 15 ESBL-Eb.	Water	119-124	EsbL	Escherichia coli	35-39
25791254-3	2015	ESBL-producing Enterobacteriaceae (ESBL-Eb) were detected in 10 of the 109 farm samples (vegetables, 8.2%; soil, 7.3%; water, 15.8%), and in 4 of 45 vegetables of markets (8.9%), recovering 15 ESBL-Eb.	Water	119-124	EsbL	Escherichia coli	35-39
25715889-2	2015	It is possible to redirect electrons from QA(-) to water-soluble Co(III) complexes, which opens a new avenue for harvesting electrons from water oxidation by immobilization of PSII on electrode surfaces.	Water	51-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	65-72
25715889-2	2015	It is possible to redirect electrons from QA(-) to water-soluble Co(III) complexes, which opens a new avenue for harvesting electrons from water oxidation by immobilization of PSII on electrode surfaces.	Water	139-144	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	65-72
26010118-9	2015	In addition, the Portland Harbor is impacted by PCBs generated inadvertently during the production of pigments, such as PCB 11, which alone exceeded the 64 pg/L federal water quality standard for the sum of PCBs in two of 120 whole water samples.	Water	169-174	pyruvate carboxylase	Homo sapiens	48-51
26089668-10	2015	CONCLUSION: This study indicates that PBCA NPs coated with P-80 can be potential drug carriers for poorly water-soluble drugs.	Water	106-111	TATA-box binding protein associated factor 6	Rattus norvegicus	59-63
25804520-1	2015	Cu/ZnSOD (copper/zinc superoxide dismutase) primarily scavenges cytosolic reactive oxygen species (ROS) by converting ROS to hydrogen peroxide, which is then converted to water by the catalytic action of catalase, thus playing a pivotal role in the first line of defense mechanism against oxidative stress.	Water	171-176	catalase	Lates calcarifer	204-212
26106595-7	2015	Results reveal very low or even missing ground water recharge for SRC compared to agricultural land use or grassland, especially succeeding dry years.	Water	47-52	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	66-69
25532697-7	2015	The difference in the IC50 values for sulindac between AR (0.36 muM) and AKR1B10 (2.7 muM) might be explained by the different positioning and stacking interaction given by Phe122/Phe123, and by the presence of two buried and ordered water molecules in AKR1B10 but not in AR.	Water	234-239	aldo-keto reductase family 1 member B	Homo sapiens	55-57
25946487-8	2015	Moreover, the possibility of multiple H-bonding interactions of water molecules with the carboxylate anion is put forward to account for the higher water uptake with respect to parent MSN.	Water	64-69	moesin	Homo sapiens	184-187
25946487-8	2015	Moreover, the possibility of multiple H-bonding interactions of water molecules with the carboxylate anion is put forward to account for the higher water uptake with respect to parent MSN.	Water	148-153	moesin	Homo sapiens	184-187
26042828-9	2015	In mice, mild water restriction that elevates serum sodium by 5 mmol/l, increased VCAM1, E-selectin and MCP-1 expression in mouse tissues, accelerated atherosclerotic plaque formation in aortic root and caused thickening or walls of coronary arteries.	Water	14-19	selectin, endothelial cell	Mus musculus	89-99
26042828-9	2015	In mice, mild water restriction that elevates serum sodium by 5 mmol/l, increased VCAM1, E-selectin and MCP-1 expression in mouse tissues, accelerated atherosclerotic plaque formation in aortic root and caused thickening or walls of coronary arteries.	Water	14-19	mast cell protease 1	Mus musculus	104-109
26531013-3	2015	However, the molecular mechanism of PsbO involvement in photosynthetic water oxidation remains unclear.	Water	71-76	uncharacterized protein	Chlamydomonas reinhardtii	36-40
25978295-8	2015	Based on the obtained data, location-specific silicone rubber-water partition coefficients (Ksr-w; adjusted for temperature and salinity) can be calculated.	Water	62-67	kinase suppressor of ras 1	Homo sapiens	92-95
25914924-8	2015	Additionally, food and water deprivation significantly increased hippocampus IL-1beta while food and water deprivation only increased hypothalamus IL-1beta in stress-susceptible animals.	Water	23-28	interleukin 1 beta	Homo sapiens	77-85
25914924-8	2015	Additionally, food and water deprivation significantly increased hippocampus IL-1beta while food and water deprivation only increased hypothalamus IL-1beta in stress-susceptible animals.	Water	101-106	interleukin 1 beta	Homo sapiens	147-155
25797519-11	2015	Molecular dynamics simulations on glycerol-specific GlpF, water-transporting AQP1, its mutant and a fungal AQP channel confirm these predictions.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	77-81
26240594-2	2015	Water reabsorption in the collecting duct cells is regulated by arginine vasopressin (AVP) via the vasopressin V2-receptor (V2R).	Water	0-5	arginine vasopressin	Homo sapiens	73-84
26240594-2	2015	Water reabsorption in the collecting duct cells is regulated by arginine vasopressin (AVP) via the vasopressin V2-receptor (V2R).	Water	0-5	arginine vasopressin receptor 2	Homo sapiens	99-122
26240594-2	2015	Water reabsorption in the collecting duct cells is regulated by arginine vasopressin (AVP) via the vasopressin V2-receptor (V2R).	Water	0-5	arginine vasopressin receptor 2	Homo sapiens	124-127
26601352-0	2015	[Monitoring Water in Lubricating Oil with Min-Infrared LED].	Water	12-17	small integral membrane protein 10 like 2A	Homo sapiens	55-58
25903037-1	2015	The cystic fibrosis transmembrane conductance regulator (CFTR) is a cyclic AMP-dependent protein kinase (PKA)-regulated Cl(-) channel, crucial for epithelial cell regulation of salt and water transport.	Water	186-191	CF transmembrane conductance regulator	Homo sapiens	4-55
25903037-1	2015	The cystic fibrosis transmembrane conductance regulator (CFTR) is a cyclic AMP-dependent protein kinase (PKA)-regulated Cl(-) channel, crucial for epithelial cell regulation of salt and water transport.	Water	186-191	CF transmembrane conductance regulator	Homo sapiens	57-61
26601352-1	2015	A method that could be used to quantify the water concentration in ship machinery lubricating oil based on Mid-infrared LED is discussed.	Water	44-49	small integral membrane protein 10 like 2A	Homo sapiens	120-123
26038909-4	2015	Twelve (5%) of the 238 RTE products and one of the recycled wash water samples yielded ESBL-producing Enterobacteriaceae.	Water	65-70	EsbL	Escherichia coli	87-91
26221479-5	2015	Furthermore, the water extract, but not the ethanol extract, of the GJ dose-dependently inhibited LPS-induced JNK2/1 and slightly p38 mitogen-activated protein kinases (MAPK), and cyclooxygenase-2 (COX-2) expression in BV-2 cells.	Water	17-22	mitogen-activated protein kinase 9	Mus musculus	110-116
25768671-11	2015	Without prior thirsting, a single baseline copeptin level &gt;21.4 pmol/L differentiated nephrogenic DI from other etiologies with a 100% sensitivity and specificity, rendering a water deprivation testing unnecessary in such cases.	Water	179-184	arginine vasopressin	Homo sapiens	43-51
25873687-1	2015	Polyphenol oxidase (PPO) catalyses the oxidation of monophenols and/or o-diphenols to o-quinones with the concomitant reduction of oxygen to water which results in protein complexing and the formation of brown melanin pigments.	Water	141-146	protoporphyrinogen oxidase	Homo sapiens	0-18
25873687-1	2015	Polyphenol oxidase (PPO) catalyses the oxidation of monophenols and/or o-diphenols to o-quinones with the concomitant reduction of oxygen to water which results in protein complexing and the formation of brown melanin pigments.	Water	141-146	protoporphyrinogen oxidase	Homo sapiens	20-23
25892399-3	2015	The oral insulin/DCK complex was prepared by making a physical complex of insulin aspart with DCK through ion-pair interaction in water.	Water	130-135	insulin	Homo sapiens	9-16
25601490-7	2015	It was revealed that GLT-1 and xCT expressions were downregulated in both the amygdala and the hippocampus of ethanol-vehicle-treated rats (ethanol-vehicle group) compared with water-control animals.	Water	177-182	solute carrier family 1 member 2	Rattus norvegicus	21-26
26387296-6	2015	Na+ was a characteristic water-soluble ion for the desulfurizer NaOH, NH4+ and NO3+ were characteristic for the desulfurizer NH4HCO3, and Mg2+ was characteristic for the desulfurizer MgO, but the Ca2+ emission was not increased by addition of the desulfurizer CaO or CaCO3 The concentrations of NH4+ and NO3- in fumes of thermal power plant were lower than those in fumes of industrial or heating coal fired boilers.	Water	25-30	NBL1, DAN family BMP antagonist	Homo sapiens	79-82
26387311-4	2015	The ratios of Cl-, NO3- and SO4(2-) in the allogenic water from the shale area in the northern catchment were higher than those in autogenic water from the dolomite karst area, so did the concentration of Si.	Water	53-58	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
25185720-7	2015	ICH mice (TLR4-/-) had reduced water content and neurological injury compared with ICH mice (WT).	Water	31-36	toll-like receptor 4	Mus musculus	10-14
25875917-0	2015	Adsorption of Bovine Serum Albumin (BSA) at the Oil/Water Interface: A Neutron Reflection Study.	Water	52-57	albumin	Homo sapiens	21-34
25603016-3	2015	Catalase is a potent antioxidant enzyme that coverts hydrogen peroxide into hydrogen and water.	Water	89-94	catalase	Homo sapiens	0-8
25869070-10	2015	The results suggest that altered UT-B expression in the CP may contribute to an imbalance of water and electrolytes in the CSF of Dahl S rats on high salt diet, thereby leading to alterations in MAP.	Water	93-98	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	33-37
26022140-5	2015	Male Fischer 344 rats were randomly assigned into 4 groups: young rats (3 months old) provided with tap water or with 15 g/L GP dissolved in tap water for 3 weeks, aged rats (21 months old) provided with tap water or with GP-treated tap water for 3 weeks (AG-GP).	Water	145-150	nuclear RNA export factor 1	Rattus norvegicus	141-144
26022140-5	2015	Male Fischer 344 rats were randomly assigned into 4 groups: young rats (3 months old) provided with tap water or with 15 g/L GP dissolved in tap water for 3 weeks, aged rats (21 months old) provided with tap water or with GP-treated tap water for 3 weeks (AG-GP).	Water	145-150	nuclear RNA export factor 1	Rattus norvegicus	141-144
26022140-5	2015	Male Fischer 344 rats were randomly assigned into 4 groups: young rats (3 months old) provided with tap water or with 15 g/L GP dissolved in tap water for 3 weeks, aged rats (21 months old) provided with tap water or with GP-treated tap water for 3 weeks (AG-GP).	Water	145-150	nuclear RNA export factor 1	Rattus norvegicus	141-144
26022140-5	2015	Male Fischer 344 rats were randomly assigned into 4 groups: young rats (3 months old) provided with tap water or with 15 g/L GP dissolved in tap water for 3 weeks, aged rats (21 months old) provided with tap water or with GP-treated tap water for 3 weeks (AG-GP).	Water	145-150	nuclear RNA export factor 1	Rattus norvegicus	141-144
26022140-5	2015	Male Fischer 344 rats were randomly assigned into 4 groups: young rats (3 months old) provided with tap water or with 15 g/L GP dissolved in tap water for 3 weeks, aged rats (21 months old) provided with tap water or with GP-treated tap water for 3 weeks (AG-GP).	Water	145-150	nuclear RNA export factor 1	Rattus norvegicus	141-144
26022140-5	2015	Male Fischer 344 rats were randomly assigned into 4 groups: young rats (3 months old) provided with tap water or with 15 g/L GP dissolved in tap water for 3 weeks, aged rats (21 months old) provided with tap water or with GP-treated tap water for 3 weeks (AG-GP).	Water	145-150	nuclear RNA export factor 1	Rattus norvegicus	141-144
26022140-5	2015	Male Fischer 344 rats were randomly assigned into 4 groups: young rats (3 months old) provided with tap water or with 15 g/L GP dissolved in tap water for 3 weeks, aged rats (21 months old) provided with tap water or with GP-treated tap water for 3 weeks (AG-GP).	Water	145-150	nuclear RNA export factor 1	Rattus norvegicus	141-144
26022140-5	2015	Male Fischer 344 rats were randomly assigned into 4 groups: young rats (3 months old) provided with tap water or with 15 g/L GP dissolved in tap water for 3 weeks, aged rats (21 months old) provided with tap water or with GP-treated tap water for 3 weeks (AG-GP).	Water	145-150	nuclear RNA export factor 1	Rattus norvegicus	141-144
26022140-5	2015	Male Fischer 344 rats were randomly assigned into 4 groups: young rats (3 months old) provided with tap water or with 15 g/L GP dissolved in tap water for 3 weeks, aged rats (21 months old) provided with tap water or with GP-treated tap water for 3 weeks (AG-GP).	Water	145-150	nuclear RNA export factor 1	Rattus norvegicus	141-144
26020609-1	2015	In this work, fluorescent gold nanocluster (AuNC) decorated polycaprolactone (PCL) nanofibers (AuNC*PCL-NF) for real time visual monitoring of Hg(2+) detection at ppt level in water is demonstrated.	Water	176-181	tachykinin precursor 1	Homo sapiens	163-166
25850716-2	2015	The peroxidase activity of the bound CytC increased up to two orders of magnitude in organic solvents compared to the activity of unbound CytC in water.	Water	146-151	cytochrome c, somatic	Homo sapiens	37-41
25850716-2	2015	The peroxidase activity of the bound CytC increased up to two orders of magnitude in organic solvents compared to the activity of unbound CytC in water.	Water	146-151	cytochrome c, somatic	Homo sapiens	138-142
25850716-5	2015	A CytC-Ac-KLVFFAE-NH2 hybrid featuring nanofiber morphology showed 308-fold higher activity than unbound CytC in water, which increased to 450-fold with the nanotube morphology of CytC-Ac-KLVFFAL-NH2 .	Water	113-118	cytochrome c, somatic	Homo sapiens	2-6
25850716-5	2015	A CytC-Ac-KLVFFAE-NH2 hybrid featuring nanofiber morphology showed 308-fold higher activity than unbound CytC in water, which increased to 450-fold with the nanotube morphology of CytC-Ac-KLVFFAL-NH2 .	Water	113-118	cytochrome c, somatic	Homo sapiens	105-109
25850716-5	2015	A CytC-Ac-KLVFFAE-NH2 hybrid featuring nanofiber morphology showed 308-fold higher activity than unbound CytC in water, which increased to 450-fold with the nanotube morphology of CytC-Ac-KLVFFAL-NH2 .	Water	113-118	cytochrome c, somatic	Homo sapiens	105-109
25901942-0	2015	Confocal Raman Microscopy for in Situ Measurement of Octanol-Water Partitioning within the Pores of Individual C18-Functionalized Chromatographic Particles.	Water	61-66	Bardet-Biedl syndrome 9	Homo sapiens	111-114
25940322-2	2015	The SPI was incubated up to 5 h in pH 1.5 solutions at room temperature or in a heated water bath (50 or 60  C) to lead to protein structural unfolding, followed by refolding at pH 7.0 for 1 h. The combination of pH-shifting and heating treatments resulted in drastic increases in the SPI gel penetration force (p &lt; 0.05).	Water	87-92	chromogranin A	Homo sapiens	4-7
25679479-3	2015	We use octadecyl type hydrocarbon (C18) functionalized spherical particles (polystyrene and silica) with diameters in the range 1-5 mum, and a selected mixture of solvents for accurate control of the surface tension and particles" mobility at the water surface.	Water	247-252	Bardet-Biedl syndrome 9	Homo sapiens	35-38
25651559-7	2015	In the medullary collecting duct, ANP reduces sodium reabsorption by inhibiting the cyclic nucleotide-gated cation channels, the epithelial sodium channel, and the heteromeric channel transient receptor potential-vanilloid 4 and -polycystin 2 and diminishes vasopressin-induced water reabsorption.	Water	278-283	natriuretic peptide A	Homo sapiens	34-37
25651559-8	2015	Long-term ANP treatment may lead to NPR-A desensitization and ANP resistance, resulting in augmented sodium and water reabsorption.	Water	112-117	natriuretic peptide A	Homo sapiens	10-13
25651559-10	2015	Characteristics of ANP resistance and corin deficiency are also encountered in patients with edema-associated diseases, highlighting the importance of ANP signaling in salt-water balance and renal pathophysiology.	Water	173-178	natriuretic peptide A	Homo sapiens	19-22
25651559-10	2015	Characteristics of ANP resistance and corin deficiency are also encountered in patients with edema-associated diseases, highlighting the importance of ANP signaling in salt-water balance and renal pathophysiology.	Water	173-178	corin, serine peptidase	Homo sapiens	38-43
25651559-10	2015	Characteristics of ANP resistance and corin deficiency are also encountered in patients with edema-associated diseases, highlighting the importance of ANP signaling in salt-water balance and renal pathophysiology.	Water	173-178	natriuretic peptide A	Homo sapiens	151-154
25459055-0	2015	Magnetic bead droplet immunoassay of oligomer amyloid beta for the diagnosis of Alzheimer"s disease using micro-pillars to enhance the stability of the oil-water interface.	Water	156-161	amyloid beta precursor protein	Homo sapiens	46-58
25736394-6	2015	The models based on a 12-6-4 potential offered improvement, and one model in particular, in conjunction with the SPC/E water model, performed exceptionally well for all properties.	Water	119-124	proline rich protein gene cluster	Homo sapiens	113-116
25807174-6	2015	Such complex formation between the blocks of PPO-b-PDMAEMA is prevented in bulk water but facilitated at the interface.	Water	80-85	protoporphyrinogen oxidase	Homo sapiens	45-48
26221267-8	2015	Since ManLAM is the major component of water phase, we found that ManLAM induced IL-37 mRNA and protein expression in a time and dose-dependent manner, while this activity was almost totally abolished by the ERK1/2 (U0126) and p38 (SB203580) inhibitor.	Water	39-44	mitogen-activated protein kinase 3	Homo sapiens	208-214
26239456-0	2015	Hyponatremia Associated with Heart Failure: Pathological Role of Vasopressin-Dependent Impaired Water Excretion.	Water	96-101	arginine vasopressin	Homo sapiens	65-76
25911430-0	2015	Preparation of C18 composite solid-phase microextraction fiber and its application to the determination of organochlorine pesticides in water samples.	Water	136-141	Bardet-Biedl syndrome 9	Homo sapiens	15-18
25911430-1	2015	In this work, a C18 composite solid-phase microextraction (SPME) fiber was prepared with a new method and applied to the analysis of organochlorine pesticides (OCPs) in water sample.	Water	169-174	Bardet-Biedl syndrome 9	Homo sapiens	16-19
26263332-5	2015	Hyperpolarized water also enhances proton signals of proteins at concentrations below 20 muM so that one can verify in a few seconds whether the proteins remain intact or have been denatured.	Water	15-20	latexin	Homo sapiens	89-92
25855367-0	2015	Synthesis of Monodispersed Submillimeter-Sized Molecularly Imprinted Particles Selective for Human Serum Albumin Using Inverse Suspension Polymerization in Water-in-Oil Emulsion Prepared Using Microfluidics.	Water	156-161	albumin	Homo sapiens	99-112
25977381-10	2015	Moreover, water-soluble beta-glucan enhanced IFN-gamma production more effectively than did particulate beta-glucan.	Water	10-15	interferon gamma	Mus musculus	45-54
25728706-3	2015	Feeding PPARbeta/delta-deficient mice with fructose exacerbated glucose intolerance and led to macrophage infiltration, inflammation, enhanced mRNA and protein levels of CD36, and activation of the JNK pathway in white adipose tissue compared to those of water-fed PPARbeta/delta-deficient mice.	Water	255-260	peroxisome proliferator activator receptor delta	Mus musculus	8-16
25728706-7	2015	Protein levels of the well-known Nrf2 target gene NAD(P)H: quinone oxidoreductase 1 (Nqo1) were increased in water-fed PPARbeta/delta-null mice, suggesting that PPARbeta/delta deficiency increases Nrf2 activity; and this increase was exacerbated in fructose-fed PPARbeta/delta-deficient mice.	Water	109-114	nuclear factor, erythroid derived 2, like 2	Mus musculus	33-37
25728706-7	2015	Protein levels of the well-known Nrf2 target gene NAD(P)H: quinone oxidoreductase 1 (Nqo1) were increased in water-fed PPARbeta/delta-null mice, suggesting that PPARbeta/delta deficiency increases Nrf2 activity; and this increase was exacerbated in fructose-fed PPARbeta/delta-deficient mice.	Water	109-114	peroxisome proliferator activator receptor delta	Mus musculus	119-127
25728706-7	2015	Protein levels of the well-known Nrf2 target gene NAD(P)H: quinone oxidoreductase 1 (Nqo1) were increased in water-fed PPARbeta/delta-null mice, suggesting that PPARbeta/delta deficiency increases Nrf2 activity; and this increase was exacerbated in fructose-fed PPARbeta/delta-deficient mice.	Water	109-114	peroxisome proliferator activator receptor delta	Mus musculus	161-169
25728706-7	2015	Protein levels of the well-known Nrf2 target gene NAD(P)H: quinone oxidoreductase 1 (Nqo1) were increased in water-fed PPARbeta/delta-null mice, suggesting that PPARbeta/delta deficiency increases Nrf2 activity; and this increase was exacerbated in fructose-fed PPARbeta/delta-deficient mice.	Water	109-114	nuclear factor, erythroid derived 2, like 2	Mus musculus	197-201
25728706-7	2015	Protein levels of the well-known Nrf2 target gene NAD(P)H: quinone oxidoreductase 1 (Nqo1) were increased in water-fed PPARbeta/delta-null mice, suggesting that PPARbeta/delta deficiency increases Nrf2 activity; and this increase was exacerbated in fructose-fed PPARbeta/delta-deficient mice.	Water	109-114	peroxisome proliferator activator receptor delta	Mus musculus	161-169
25667219-1	2015	Water homeostasis and the structural integrity of the vertebrate lens is partially mediated by AQP0 channels.	Water	0-5	major intrinsic protein of lens fiber	Homo sapiens	95-99
25877886-6	2015	Regression analysis suggested that (1) nirK gene abundance was correlated with pile temperature following quadratic model; (2) nirS gene abundance was linearly correlated with pile temperature and concentration of NH4 (+), while correlated with concentration of NO3 (-) and pH following inverse and quadratic model respectively; (3) nosZ gene abundance was quadratically correlated with pH and linearly correlated with water soluble carbon (WSC).	Water	419-424	NBL1, DAN family BMP antagonist	Homo sapiens	262-265
25795251-0	2015	A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib.	Water	6-11	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	96-100
25739654-11	2015	11beta-HSD1 expression and activity were also induced by 200 and 100 (but not 50) mJ/cm(2) UVB and correlated with increased transepidermal water loss (indicative of barrier disruption).	Water	140-145	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	0-11
26180273-0	2015	Effect of Water Miscible Organic Solvents on p-Nitrophenol Hydroxylase (CYP2E1) Activity in Rat Liver Microsomes.	Water	10-15	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	72-78
25933120-7	2015	To propose a concrete therapeutic approach, siRNA TMPRSS2-ERG IV was conjugated to squalene, which can self-organize as nanoparticles in water.	Water	137-142	transmembrane serine protease 2	Homo sapiens	50-57
26191130-4	2015	In the DAI group, the expressions of beta-APP and NF-L in axons were increased from 12 to 72 h. The ultrastructural observation indicated the axon and vessel injury appeared at 12 h post-injury and severely aggravated from 24 to 72 h. The expression of vWF and brain water content was increased at 12 h after injury and further increased at 24 h. Nimodipine decreased the expression of beta-APP, NF-L and vWF, and also attenuated the ultrastructural damage of vascular wall and axons.	Water	267-272	neurofilament light chain	Rattus norvegicus	50-54
26155499-6	2015	Pearson"s correlation found a statistically significant correlation between fluoride concentrations in cow"s and buffalo"s milk with varying levels of fluoride concentration in drinking water in zone B and zone C. However, this correlation was not statistically significant in zone A.	Water	186-191	Weaning weight-maternal milk	Bos taurus	123-127
25968258-9	2015	High concentrations of aerosols and water vapor favored the conversion of SO2 to SO4(2-) and NO2 to NO3-, which accelerated the accumulation of the aerosols and resulted in the formation of haze in Beijing.	Water	36-41	NBL1, DAN family BMP antagonist	Homo sapiens	100-103
25933120-7	2015	To propose a concrete therapeutic approach, siRNA TMPRSS2-ERG IV was conjugated to squalene, which can self-organize as nanoparticles in water.	Water	137-142	ETS transcription factor ERG	Homo sapiens	58-61
25701629-0	2015	The influence of residual water on the secondary structure and crystallinity of freeze-dried fibrinogen.	Water	26-31	fibrinogen beta chain	Homo sapiens	93-103
25701629-1	2015	The purpose of this work was to investigate the influence of water content on the secondary structure of a freeze-dried protein (fibrinogen) after a storage period of two weeks.	Water	61-66	fibrinogen beta chain	Homo sapiens	129-139
25860879-2	2015	In this research, we applied confocal Raman technology combined with optical microscopy to investigate the relationship between the hygroscopic behavior and the molecular interactions of mixed glycerol/Mg(NO3)2/water droplets.	Water	211-216	NBL1, DAN family BMP antagonist	Homo sapiens	205-208
25893997-3	2015	In total, 119 ESBL-producing E. coli were isolated from feces, air samples, water, sludge and soil samples.	Water	76-81	EsbL	Escherichia coli	14-18
25844814-13	2015	The fluctuating thermodynamics analysis of the misfolding and dimerization of the Abeta protein indicates that the interaction of the protein with surrounding water plays a critical role in protein aggregation.	Water	159-164	amyloid beta precursor protein	Homo sapiens	82-87
25844814-14	2015	Such a water-centric perspective is further corroborated by demonstrating that, for a large number of Abeta mutants and mutants of other protein systems, the change in the experimental aggregation propensity upon mutation has a significant correlation with the protein solvation free energy change.	Water	7-12	amyloid beta precursor protein	Homo sapiens	102-107
25858030-11	2015	Pharmacological blockade of the AT1 receptor with losartan prior to RNS abolished both the functional and the molecular responses, suggesting that intrarenal Ang II acting via the AT1 receptor is a major factor for NHE3-mediated sodium and water reabsorption induced by RNS.	Water	240-245	angiotensinogen	Homo sapiens	158-164
27774415-3	2016	This placebo-controlled double-blind trial tested the effects of a dried water extract of cinnamon (Cinnamomum cassia) on circulating glucose, lipids, insulin, and insulin resistance.	Water	73-78	insulin	Homo sapiens	164-171
27774415-10	2016	In conclusion, supplementation with 500 mg of water-extract of cinnamon for two months reduced fasting insulin, glucose, total cholesterol, and LDL cholesterol and enhanced insulin sensitivity of subjects with elevated blood glucose.	Water	46-51	insulin	Homo sapiens	103-110
27774415-10	2016	In conclusion, supplementation with 500 mg of water-extract of cinnamon for two months reduced fasting insulin, glucose, total cholesterol, and LDL cholesterol and enhanced insulin sensitivity of subjects with elevated blood glucose.	Water	46-51	insulin	Homo sapiens	173-180
25510608-2	2015	However, the resistance of defoggers made from conventional transferred graphene increases sharply once both sides of the film are covered by water molecules which, in turn, leads to a temperature drop that is inefficient for fog removal.	Water	142-147	zinc finger protein, FOG family member 1	Homo sapiens	29-32
25803267-0	2015	Vapor-liquid equilibrium and polarization behavior of the GCP water model: Gaussian charge-on-spring versus dipole self-consistent field approaches to induced polarization.	Water	62-67	golgin B1	Homo sapiens	58-61
25837687-1	2015	In a kinetic experiment on the SN2 reaction of sodium p-nitrophenoxide with iodomethane in acetone-water mixed solvent, Humeres et al.	Water	99-104	solute carrier family 38 member 5	Homo sapiens	31-34
25624099-4	2015	We show that optogenetic activation of subfornical organ excitatory neurons, marked by the expression of the transcription factor ETV-1, evokes intense drinking behaviour, and does so even in fully water-satiated animals.	Water	198-203	ETS variant transcription factor 1	Homo sapiens	130-135
25466060-1	2015	In this study the impact of covalent complexes of alpha-lactalbumin (alpha-La) with (-)-epigallocatechin gallate (EGCG) or chlorogenic acid (CA) was investigated on the physicochemical properties of beta-carotene oil-in-water emulsions.	Water	220-225	lactalbumin alpha	Homo sapiens	50-67
25466060-1	2015	In this study the impact of covalent complexes of alpha-lactalbumin (alpha-La) with (-)-epigallocatechin gallate (EGCG) or chlorogenic acid (CA) was investigated on the physicochemical properties of beta-carotene oil-in-water emulsions.	Water	220-225	lactalbumin alpha	Homo sapiens	69-77
25706509-3	2015	The dynamics of water in the interdomain region between an E3 ubiquitin ligase (MDM2) and three different peptides derived from the tumor suppressor protein p53 are studied using molecular dynamics.	Water	16-21	tumor protein p53	Homo sapiens	157-160
25466060-4	2015	The least degradation of beta-carotene occurred in the emulsion stabilised with the alpha-La-EGCG covalent complex when stored at 25  C. These results implied that protein-polyphenol covalent complexes were able to enhance the physical stability of beta-carotene emulsion and inhibit the degradation of beta-carotene in oil-in-water emulsion, and the effect was influenced by the types of the phenolic compounds.	Water	327-332	lactalbumin alpha	Homo sapiens	84-92
25767829-5	2015	Yet, unlike the empty HII systems, insulin perturbed the GMO-water interface while decreasing the movement of the GMO headgroup, and reducing T0 (296 K).	Water	61-66	insulin	Homo sapiens	35-42
25931819-7	2015	Additionally, this paper evidenced the dimer had the basic structural unit of Cu(2+)-FS in water, theoretically simulated the formation of Cu(2+)-FS nanoparticles, and identified that Cu(2+)-FS activity in decreasing glycoprotein IIb/IIIa, P-selectin, and IL-8 was responsible for the antithrombotic action.	Water	91-96	C-X-C motif chemokine ligand 8	Homo sapiens	256-260
25883547-8	2015	Recent studies have shown that MLC1 establishes structural and/or functional interactions with several ion/water channels and transporters and ion channel accessory proteins, and that these interactions are affected by MLC1 mutations causing MLC.	Water	107-112	modulator of VRAC current 1	Homo sapiens	31-35
25851941-4	2015	This technique, called SIMPLEx (solubilization of IMPs with high levels of expression), allows the direct expression of soluble products in living cells by simply fusing an IMP target with truncated apolipoprotein A-I, which serves as an amphipathic proteic "shield" that sequesters the IMP from water and promotes its solubilization.	Water	296-301	apolipoprotein A1	Homo sapiens	199-217
32262909-6	2015	In this process, the results of quartz crystal microbalance, X-ray photoelectron spectroscopy and water contact angle studies indicate that DA, SPA and anti-CD34 Ab were successfully immobilized onto the surface step by step.	Water	98-103	CD34 molecule	Homo sapiens	157-161
25838982-2	2015	Claudin-2, one of the 27 mammalian claudins regulating that barrier function, forms a paracellular channel for small cations and water.	Water	129-134	claudin 2	Homo sapiens	0-9
25588773-0	2015	Systematic evaluation of bundled SPC water for biomolecular simulations.	Water	37-42	proline rich protein gene cluster	Homo sapiens	33-36
25588773-1	2015	In bundled SPC water models, the relative motion of groups of four water molecules is restrained by distance-dependent potentials.	Water	15-20	proline rich protein gene cluster	Homo sapiens	11-14
25588773-1	2015	In bundled SPC water models, the relative motion of groups of four water molecules is restrained by distance-dependent potentials.	Water	67-72	proline rich protein gene cluster	Homo sapiens	11-14
25588773-2	2015	Bundled SPC models have been used in hybrid all-atom/coarse-grained (AA/CG) multiscale simulations, since they enable to couple atomistic SPC water with supra-molecular CG water models that effectively represent more than a single water molecule.	Water	142-147	proline rich protein gene cluster	Homo sapiens	8-11
25588773-2	2015	Bundled SPC models have been used in hybrid all-atom/coarse-grained (AA/CG) multiscale simulations, since they enable to couple atomistic SPC water with supra-molecular CG water models that effectively represent more than a single water molecule.	Water	172-177	proline rich protein gene cluster	Homo sapiens	8-11
25588773-2	2015	Bundled SPC models have been used in hybrid all-atom/coarse-grained (AA/CG) multiscale simulations, since they enable to couple atomistic SPC water with supra-molecular CG water models that effectively represent more than a single water molecule.	Water	172-177	proline rich protein gene cluster	Homo sapiens	8-11
25588773-3	2015	In the present work, we systematically validated and critically tested bundled SPC water models as solvent for biomolecular simulations.	Water	83-88	proline rich protein gene cluster	Homo sapiens	79-82
25588773-5	2015	Potentials of mean force of dimerization of pairs of amino acid side chains as well as hydration free energies of single side chains obtained with bundled SPC and standard (unrestrained) SPC water agree closely with each other and with experimental data.	Water	191-196	proline rich protein gene cluster	Homo sapiens	187-190
25588773-8	2015	Analysis of the end-to-end distance autocorrelation times of the Ala5 and (GS)2 peptides shows that sampling in more viscous bundled SPC water is about two times slower.	Water	137-142	proline rich protein gene cluster	Homo sapiens	133-136
25588773-9	2015	Pronounced differences between the water models were found for the structure of a coiled-coil dimer, which is instable in bundled SPC but not in standard SPC.	Water	35-40	proline rich protein gene cluster	Homo sapiens	130-133
25588773-11	2015	Bundled SPC leads to an increased hydration of the active site region, more hydrogen bonds between water and catalytic triad residues, and a significantly slower exchange of water molecules between the active site and the bulk.	Water	99-104	proline rich protein gene cluster	Homo sapiens	8-11
25588773-11	2015	Bundled SPC leads to an increased hydration of the active site region, more hydrogen bonds between water and catalytic triad residues, and a significantly slower exchange of water molecules between the active site and the bulk.	Water	174-179	proline rich protein gene cluster	Homo sapiens	8-11
25588773-12	2015	Our results form a basis for assessing the accuracy that can be expected from bundled SPC water models.	Water	90-95	proline rich protein gene cluster	Homo sapiens	86-89
26146537-6	2015	Seventeen anions were screened with the library under an epifluorescence microscope, ultimately yielding eight chemosensors that could discriminate 250 muM solutions of all 17 anions in buffered water using their patterns of response.	Water	195-200	latexin	Homo sapiens	152-155
25617832-0	2015	The influence of residual water on the solid-state properties of freeze-dried fibrinogen.	Water	26-31	fibrinogen beta chain	Homo sapiens	78-88
26197570-4	2015	Both background spectrum of the empty ATR cell and that of the water on ATR cell are used in sequence.	Water	63-68	ATR serine/threonine kinase	Homo sapiens	72-75
25883547-8	2015	Recent studies have shown that MLC1 establishes structural and/or functional interactions with several ion/water channels and transporters and ion channel accessory proteins, and that these interactions are affected by MLC1 mutations causing MLC.	Water	107-112	modulator of VRAC current 1	Homo sapiens	219-223
25883547-8	2015	Recent studies have shown that MLC1 establishes structural and/or functional interactions with several ion/water channels and transporters and ion channel accessory proteins, and that these interactions are affected by MLC1 mutations causing MLC.	Water	107-112	modulator of VRAC current 1	Homo sapiens	31-34
25493652-3	2015	Our fieldwork in Bangladesh demonstrated that levels of placental growth factor (PlGF) in urine samples from residents of cancer-prone areas with arsenic-polluted drinking water were higher than those in urine samples from residents of an area that was not polluted with arsenic.	Water	172-177	placental growth factor	Homo sapiens	56-79
26685505-7	2015	Injection of Orexin B antagonist decreased the food and water intake significantly.	Water	56-61	hypocretin neuropeptide precursor	Rattus norvegicus	13-19
26685510-8	2015	In rats receiving tap water, PBG produced bradycardia, hypotension and tachypnoea.	Water	22-27	nuclear RNA export factor 1	Rattus norvegicus	18-21
25493652-3	2015	Our fieldwork in Bangladesh demonstrated that levels of placental growth factor (PlGF) in urine samples from residents of cancer-prone areas with arsenic-polluted drinking water were higher than those in urine samples from residents of an area that was not polluted with arsenic.	Water	172-177	placental growth factor	Homo sapiens	81-85
25154023-3	2015	Catalase gene encodes an antioxidant enzyme, detoxifying hydrogen peroxide to H2O and O2.	Water	78-81	catalase	Homo sapiens	0-8
25667319-0	2015	2-cysteine peroxiredoxins and thylakoid ascorbate peroxidase create a water-water cycle that is essential to protect the photosynthetic apparatus under high light stress conditions.	Water	70-75	peroxidase	Arabidopsis thaliana	50-60
25503267-1	2015	Aquaporin (AQP) 9 transports glycerol and water, and belongs to the aquaglyceroporin subfamily.	Water	42-47	aquaporin 9	Homo sapiens	0-17
25667319-0	2015	2-cysteine peroxiredoxins and thylakoid ascorbate peroxidase create a water-water cycle that is essential to protect the photosynthetic apparatus under high light stress conditions.	Water	76-81	peroxidase	Arabidopsis thaliana	50-60
25667319-1	2015	Different peroxidases, including 2-cysteine (2-Cys) peroxiredoxins (PRXs) and thylakoid ascorbate peroxidase (tAPX), have been proposed to be involved in the water-water cycle (WWC) and hydrogen peroxide (H2O2)-mediated signaling in plastids.	Water	158-163	peroxidase	Arabidopsis thaliana	10-20
25667319-1	2015	Different peroxidases, including 2-cysteine (2-Cys) peroxiredoxins (PRXs) and thylakoid ascorbate peroxidase (tAPX), have been proposed to be involved in the water-water cycle (WWC) and hydrogen peroxide (H2O2)-mediated signaling in plastids.	Water	164-169	peroxidase	Arabidopsis thaliana	10-20
25545744-8	2015	Nuclear staining of NFkappaB was significantly decreased in RP tissue of men consuming GT (P = 0.013) but not BT (P = 0.931) compared to water control.	Water	137-142	nuclear factor kappa B subunit 1	Homo sapiens	20-28
25906004-4	2015	Arginine-vasopressin, which has cardiovascular effects and plays a role in water metabolism, is released from the posterior hypothalamus in response to an increase in plasma osmolality or a drop in the blood pressure, which are detected by osmoreceptors and baroreceptors respectively.	Water	75-80	arginine vasopressin	Homo sapiens	9-20
25539033-3	2015	The first group served as a control and was provided tap water.	Water	57-62	nuclear RNA export factor 1	Rattus norvegicus	53-56
25618897-0	2015	Simulating nectarine tree transpiration and dynamic water storage from responses of leaf conductance to light and sap flow to stem water potential and vapor pressure deficit.	Water	52-57	SH2 domain containing 1A	Homo sapiens	114-117
25618897-0	2015	Simulating nectarine tree transpiration and dynamic water storage from responses of leaf conductance to light and sap flow to stem water potential and vapor pressure deficit.	Water	131-136	SH2 domain containing 1A	Homo sapiens	114-117
25179274-2	2015	It is often found in surface waters in both the acidic (HTric) and basic (Tric(-)) forms (pKa ~8), and it can undergo direct photodegradation to produce several intermediates including a dioxin congener (2,8-dichlorodibenzodioxin, hereafter 28DCDD).	Water	29-35	MARVEL domain containing 2	Homo sapiens	57-61
25695769-2	2015	The treatment of compounds 1 and 2 with H2O afforded 1,2-diazene derivatives [Ru(eta(5)-C5Me5)(eta(2)-NH NH)(PPh3){P(OR)3}]BPh4 (3 and 4) and ketone Ar1Ar2CO.	Water	40-43	caveolin 1	Homo sapiens	109-113
25803851-12	2015	Drinking tap water, which contains adequate minerals, was found to be better for bone health.	Water	13-18	nuclear RNA export factor 1	Rattus norvegicus	9-12
25793528-7	2015	The pro-inflammatory cytokine, interferon-gamma may contribute to diarrhea associated with intestinal inflammation in part through regulation of the epithelial aquaporin-1 water channel via a non-classical JAK/STAT receptor signalling pathway.	Water	172-177	interferon gamma	Mus musculus	31-47
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	Water	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	Water	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	Water	90-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	Water	90-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
25609088-0	2015	Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction.	Water	10-15	carbonic anhydrase 2	Mus musculus	47-68
25609088-8	2015	This motif was also necessary for CAII to increase AQP1-mediated water flux.	Water	65-70	carbonic anhydrase 2	Mus musculus	34-38
25609088-9	2015	Red blood cell ghosts resealed with CAII demonstrated increased osmotic water permeability compared with ghosts resealed with albumin.	Water	72-77	carbonic anhydrase 2	Mus musculus	36-40
25609088-10	2015	Water flux across renal cortical membrane vesicles, measured by stopped-flow light scattering, was reduced in CAII-deficient mice compared with wild-type mice.	Water	0-5	carbonic anhydrase 2	Mus musculus	110-114
25609088-11	2015	These data are consistent with CAII increasing water conductance through AQP1 by a physical interaction between the two proteins.	Water	47-52	carbonic anhydrase 2	Mus musculus	31-35
25886760-0	2015	Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice.	Water	9-14	negative elongation factor complex member C/D, Th1l	Mus musculus	81-84
25886760-0	2015	Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice.	Water	9-14	nitric oxide synthase 2, inducible	Mus musculus	115-119
25775573-8	2015	Kinetic studies were carried out in fused water droplets for acid-induced unfolding of cytochrome c and hydrogen-deuterium exchange in bradykinin.	Water	42-47	cytochrome c, somatic	Homo sapiens	87-99
25775573-8	2015	Kinetic studies were carried out in fused water droplets for acid-induced unfolding of cytochrome c and hydrogen-deuterium exchange in bradykinin.	Water	42-47	kininogen 1	Homo sapiens	135-145
25723546-5	2015	We focused on the interaction between an ethyl methacrylate/methyl acrylate 70:30 copolymer film deposited onto a glass surface and a water/nonionic surfactant/2-butanone (MEK) ternary system, with MEK being a good solvent and water being a nonsolvent for the polymer.	Water	134-139	mitogen-activated protein kinase kinase 7	Homo sapiens	172-175
25790808-0	2015	Revealing sub-mum and mum-scale textures in H2O ice at megabar pressures by time-domain Brillouin scattering.	Water	44-47	latexin	Homo sapiens	22-25
25848248-7	2015	The commercial insulin-loaded TPGS-emulsified PEG-capped PLGA NPs (ISTPPLG NPs) were synthesized by water-oil-water emulsion solvent evaporation method.	Water	100-105	insulin	Homo sapiens	15-22
25848248-7	2015	The commercial insulin-loaded TPGS-emulsified PEG-capped PLGA NPs (ISTPPLG NPs) were synthesized by water-oil-water emulsion solvent evaporation method.	Water	110-115	insulin	Homo sapiens	15-22
25308651-1	2015	Anthocyanin, which is soluble in water and released into sugar steam during extraction, was investigated in this study.	Water	33-38	DDB1 and CUL4 associated factor 7	Homo sapiens	0-11
25576221-1	2015	Catalase is an important endogenous antioxidant enzyme that detoxifies hydrogen peroxide to oxygen and water, thus limiting the deleterious effects of reactive oxygen species.	Water	103-108	catalase	Homo sapiens	0-8
25764461-8	2015	Redundancy analysis showed that dissolved organic carbon, ammonium (NH4 (+)), ferrous iron (Fe(2+)) and nitrate (NO3 (-)) in pore water explained 33.4% of the variation in soil bacterial community composition, implying that urea regimes influenced the relative abundance of some bacterial populations possibly by regulating soil characteristics and then influencing N2O emission.	Water	130-135	NBL1, DAN family BMP antagonist	Homo sapiens	113-116
25241751-3	2015	In this laboratory study, a number of enhanced water treatment methods for DBP control, including enhanced coagulation, ozonation, and activated carbon adsorption, were evaluated for their effectiveness in treating SMP-containing water for the DBP reduction purpose.	Water	47-52	D-box binding PAR bZIP transcription factor	Homo sapiens	75-78
25241751-3	2015	In this laboratory study, a number of enhanced water treatment methods for DBP control, including enhanced coagulation, ozonation, and activated carbon adsorption, were evaluated for their effectiveness in treating SMP-containing water for the DBP reduction purpose.	Water	47-52	D-box binding PAR bZIP transcription factor	Homo sapiens	244-247
25241751-3	2015	In this laboratory study, a number of enhanced water treatment methods for DBP control, including enhanced coagulation, ozonation, and activated carbon adsorption, were evaluated for their effectiveness in treating SMP-containing water for the DBP reduction purpose.	Water	230-235	D-box binding PAR bZIP transcription factor	Homo sapiens	75-78
25241751-3	2015	In this laboratory study, a number of enhanced water treatment methods for DBP control, including enhanced coagulation, ozonation, and activated carbon adsorption, were evaluated for their effectiveness in treating SMP-containing water for the DBP reduction purpose.	Water	230-235	D-box binding PAR bZIP transcription factor	Homo sapiens	244-247
25241751-4	2015	The results show that enhanced coagulation with alum could remove SMPs only marginally and decrease the DBP formation potential (DBPFP) of the water by less than 20%.	Water	143-148	D-box binding PAR bZIP transcription factor	Homo sapiens	104-107
25241751-7	2015	It is apparent that enhanced coagulation and ozonation are not suitable for the removal of SMPs as DBP precursors from polluted water, although enhanced coagulation has been commonly used to reduce the DBP formation caused by natural organic matter.	Water	128-133	D-box binding PAR bZIP transcription factor	Homo sapiens	99-102
25760602-4	2015	The 1.65 A resolution crystal structure of AZD4547 bound to the kinase domain of FGFR1 has been determined and reveals extensive drug-protein interactions, an integral network of water molecules and the tight closure of the FGFR1 P-loop to form a long, narrow crevice in which the AZD4547 molecule binds.	Water	179-184	fibroblast growth factor receptor 1	Homo sapiens	81-86
26642682-6	2015	Also, the angiotensin-converting enzyme inhibitory activity of the cold water extract was significantly (p &lt; 0.05) higher than that of other extracts.	Water	72-77	angiotensin I converting enzyme	Rattus norvegicus	10-39
25734677-8	2015	Tolvaptan is a selective, oral vasopressin-V2-receptor-antagonist that inhibits ADH-induced retention of electrolyte-free water in the connecting duct of the kidney.	Water	122-127	arginine vasopressin receptor 2	Homo sapiens	31-54
25595964-1	2015	The expression of the water channel protein aquaporin (AQP)-5 in adult rodent and human lenses was recently reported using immunohistochemistry, molecular biology, and mass spectrometry techniques, confirming a second transmembrane water channel that is present in lens fibre cells in addition to the abundant AQP0 protein.	Water	22-27	major intrinsic protein of lens fiber	Homo sapiens	310-314
25216460-5	2015	The prepared optical membrane was successfully applied to the determination of Hg(2+) and Pb(2+) in industrial wastes, spiked tap water and natural waters without any preconcentration step.	Water	130-135	SEC14 like lipid binding 2	Homo sapiens	126-129
25750752-4	2015	Under water stress, Sids had higher membrane stability index (MSI), lower accumulated H2O2 and higher activity of the antioxidant enzymes; catalase (CAT), guaiacol peroxidase (GPX), ascorbate peroxidase (APX) and superoxide dismutase (SOD) than Gmiza.	Water	6-11	POD1	Triticum aestivum	182-202
25750752-4	2015	Under water stress, Sids had higher membrane stability index (MSI), lower accumulated H2O2 and higher activity of the antioxidant enzymes; catalase (CAT), guaiacol peroxidase (GPX), ascorbate peroxidase (APX) and superoxide dismutase (SOD) than Gmiza.	Water	6-11	POD1	Triticum aestivum	204-207
25652363-6	2015	Binding experiments were carried out at various pH in different buffers in order to dissect linked protonation of the water molecule bound to the CA VII active site, deprotonation of the sulfonamide group of the inhibitor, and protonation-deprotonation of buffer.	Water	118-123	carbonic anhydrase 7	Homo sapiens	146-152
25966344-6	2015	The third major function is ET-1 activation of ET(B) in in the nephron to reduce salt and water re-absorption.	Water	90-95	endothelin 1	Homo sapiens	28-32
25966344-6	2015	The third major function is ET-1 activation of ET(B) in in the nephron to reduce salt and water re-absorption.	Water	90-95	endothelin receptor type B	Homo sapiens	47-52
25966345-8	2015	The role of renal ET-1 and how it affects Na(+) and water transport throughout the nephron is reviewed.	Water	52-57	endothelin 1	Homo sapiens	18-22
25739567-2	2015	The results show that the stability order of all isomers in water solution is HNCO &gt; HOCN &gt; HCNO &gt; HONC &gt; Y-OC(H)N &gt; cycl-OCN(H)-a   cycl-OCN(H)-b &gt; cycl-NCO(H) &gt; HNOC &gt; HCON, i.e., the same as that in the gas phase.	Water	60-65	bone gamma-carboxyglutamate protein	Homo sapiens	89-92
25739567-2	2015	The results show that the stability order of all isomers in water solution is HNCO &gt; HOCN &gt; HCNO &gt; HONC &gt; Y-OC(H)N &gt; cycl-OCN(H)-a   cycl-OCN(H)-b &gt; cycl-NCO(H) &gt; HNOC &gt; HCON, i.e., the same as that in the gas phase.	Water	60-65	bone gamma-carboxyglutamate protein	Homo sapiens	137-140
25618660-5	2015	The method sensitivity in superficial and underground water samples was enhanced by a simple solid-phase extraction with C18 membranes, which was successful for the extraction/preconcentration of the pollutants at trace levels.	Water	54-59	Bardet-Biedl syndrome 9	Homo sapiens	121-124
25611163-4	2015	On the other hand, in linear trinuclear complex , in addition to the mu2-phenoxido and mu1,1-azido bridges with terminal octahedral Co(III) centres, the central Co(II) is bonded with two mutually trans-oxygen atoms of water molecules.	Water	218-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
25291502-2	2015	The probe had exhibited a selective and sensitive response to the sulfite against other thirteen anions and biothiols (Cys, Hcy and GSH), through the nucleophilic addition of sulfite to the alkene of probe with the detection limit of 0.1 muM in HEPES (10 mM, pH 7.4) THF/H2O (1:1, v/v).	Water	271-274	latexin	Homo sapiens	238-241
25647299-6	2015	Presented examples are as follows: (i) Reaction of the (NO(+))(NO3(-)) ion pair with a water cluster to produce the atmospherically important HONO and HNO3.	Water	87-92	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
25576641-2	2015	When the INS-loaded liposome was dispersed in water (pH 7.4), the encapsulation efficiency (EE) obtained by the column-switching HPLC system was consistent with that obtained by a conventional ultracentrifugation method.	Water	46-51	insulin	Homo sapiens	9-12
25741287-1	2015	The purpose of this investigation was to compare the effect of two commonly used therapeutic modalities (a) neuromuscular electrical stimulation (NMES) and (b) cold water immersion (CWI) on circulating tumor necrosis factor alpha (TNF-alpha) and monocyte TNF-alpha receptor (TNFR1) expression following intense acute resistance exercise and subsequent recovery.	Water	165-170	tumor necrosis factor	Homo sapiens	202-229
25627159-1	2015	Interfacial gas enrichment of dissolved gases (IGE) has been shown to cover hydrophobic solid surfaces in water.	Water	106-111	immunoglobulin heavy constant epsilon	Homo sapiens	47-50
25692550-2	2015	EAU was induced in P2Y2+/+ and P2Y2-/- mice by immunization with IRBP peptide or by adoptive transfer of in vitro restimulated semi-purified IRBP-specific enriched T lymphocytes from spleens and lymph nodes isolated from native C57Bl/6 or P2Y2+/+ and P2Y2-/- immunized mice.	Water	0-3	purinergic receptor P2Y, G-protein coupled 2	Mus musculus	19-23
25692550-2	2015	EAU was induced in P2Y2+/+ and P2Y2-/- mice by immunization with IRBP peptide or by adoptive transfer of in vitro restimulated semi-purified IRBP-specific enriched T lymphocytes from spleens and lymph nodes isolated from native C57Bl/6 or P2Y2+/+ and P2Y2-/- immunized mice.	Water	0-3	purinergic receptor P2Y, G-protein coupled 2	Mus musculus	31-35
25692550-2	2015	EAU was induced in P2Y2+/+ and P2Y2-/- mice by immunization with IRBP peptide or by adoptive transfer of in vitro restimulated semi-purified IRBP-specific enriched T lymphocytes from spleens and lymph nodes isolated from native C57Bl/6 or P2Y2+/+ and P2Y2-/- immunized mice.	Water	0-3	purinergic receptor P2Y, G-protein coupled 2	Mus musculus	31-35
25692550-2	2015	EAU was induced in P2Y2+/+ and P2Y2-/- mice by immunization with IRBP peptide or by adoptive transfer of in vitro restimulated semi-purified IRBP-specific enriched T lymphocytes from spleens and lymph nodes isolated from native C57Bl/6 or P2Y2+/+ and P2Y2-/- immunized mice.	Water	0-3	purinergic receptor P2Y, G-protein coupled 2	Mus musculus	31-35
25627159-3	2015	It was demonstrated that IGE is responsible for the unexpected stability and large contact angle of gaseous nanobubbles at the hydrophobic solid-water interface.	Water	145-150	immunoglobulin heavy constant epsilon	Homo sapiens	25-28
25236224-5	2015	Based on the results of SDS-PAGE, DSC and SEM, it was revealed that the movement of low molecular weight hydrophilic protein was depressed by the cross-linking network structure induced by TGase and SPI during film drying, indicating that adding SPI is essential to improve the thermal stability and water resistance properties of TGase-induced gelatin films.	Water	300-305	chromogranin A	Homo sapiens	246-249
25594114-0	2015	Tuning the reactivity of Fe(V)(O) toward C-H bonds at room temperature: effect of water.	Water	82-87	FEV transcription factor, ETS family member	Homo sapiens	25-30
25594114-3	2015	The formation of an Fe(V)(O) complex at room temperature in an aqueous CH3CN mixture that contains up to 90% water using NaOCl as the oxidant is reported here.	Water	109-114	FEV transcription factor, ETS family member	Homo sapiens	20-25
25594114-4	2015	The stability of Fe(V)(O) decreases with increasing water concentration.	Water	52-57	FEV transcription factor, ETS family member	Homo sapiens	17-22
25594114-5	2015	We show that the reactivity of Fe(V)(O) toward the oxidation of C-H bonds, such as those in toluene, can be tuned by varying the amount of water in the H2O/CH3CN mixture.	Water	139-144	FEV transcription factor, ETS family member	Homo sapiens	31-36
25594114-5	2015	We show that the reactivity of Fe(V)(O) toward the oxidation of C-H bonds, such as those in toluene, can be tuned by varying the amount of water in the H2O/CH3CN mixture.	Water	152-155	FEV transcription factor, ETS family member	Homo sapiens	31-36
25594114-12	2015	The DFT-optimized structure of the starting Fe(V)(O) and the transition state indicates that the rate enhancement is due to the transition state"s favored stabilization over the reactant due to enhanced hydrogen bonding with water.	Water	225-230	FEV transcription factor, ETS family member	Homo sapiens	44-49
25671581-0	2015	Carbonate ion-enriched hot spring water promotes skin wound healing in nude rats.	Water	34-39	alcohol dehydrogenase, iron containing, 1	Rattus norvegicus	23-26
32261982-5	2015	The incorporation of amine-N-oxide ensures excellent water solubility and biocompatibility, which guarantees the ratiometric detection of ALP in aqueous media and in the cells overexpressed with ALP.	Water	53-58	alkaline phosphatase, placental	Homo sapiens	138-141
32261982-5	2015	The incorporation of amine-N-oxide ensures excellent water solubility and biocompatibility, which guarantees the ratiometric detection of ALP in aqueous media and in the cells overexpressed with ALP.	Water	53-58	alkaline phosphatase, placental	Homo sapiens	195-198
25671581-6	2015	Real-time RT-PCR analysis along with zymography revealed that the wound area of the hot spring water group exhibited a higher expression of matrix metalloproteinases-2 and -9 compared to the two other control groups.	Water	95-100	alcohol dehydrogenase, iron containing, 1	Rattus norvegicus	84-87
25671581-8	2015	Our results provide the evidence that carbonate ion-enriched hot spring water is beneficial for the treatment of skin wounds.	Water	72-77	alcohol dehydrogenase, iron containing, 1	Rattus norvegicus	61-64
25533319-2	2015	An initial Co(II) amine complex 1 is prone to aerial oxidation yielding a Co(III) imine complex 2 that is further converted into an amide complex 4 in presence of adventitious water.	Water	176-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
25691829-6	2015	Condensed-phase simulations of an mDC water model are performed with the multipolar PME method and compared to an electrostatic cutoff method, which is shown to artificially increase the density of water and heat of vaporization relative to full electrostatic treatment.	Water	38-43	chemokine (C-C motif) ligand 22	Mus musculus	34-37
25660927-7	2015	Vasopressin antagonists, which promote low water permeability in the collecting ducts and, hence, free water excretion, remain under investigation for dilutional hyponatremia in ADHF.	Water	43-48	arginine vasopressin	Homo sapiens	0-11
25660927-7	2015	Vasopressin antagonists, which promote low water permeability in the collecting ducts and, hence, free water excretion, remain under investigation for dilutional hyponatremia in ADHF.	Water	103-108	arginine vasopressin	Homo sapiens	0-11
25533319-4	2015	Both the Co(III) 4 and Co(II) 5 show electrocatalytic H2 generation in weakly acidic media as well as in water.	Water	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
25556927-2	2015	In this paper, aluminum-free Mn-beta zeolite was hydrothermally synthesized in the SiO2-MnO2-(TEA)2O-NaF-H2O system.	Water	105-108	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	29-36
25459610-1	2015	A colorimetric and fluorescent dual-responses chemosensor (PT3, a water-soluble polythiophene) for streptomycin was designed and synthesized.	Water	66-71	zinc finger protein 135	Homo sapiens	59-62
25459625-3	2015	The metal complexes were found to have The structural formula ML H2O and the metal ions Mn(II), Co(II), Ni(II)) and Zn(II) were found to form tetrahedral complexes with the ligand whereas Cu(II) formed a square planar one.	Water	65-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
25556927-2	2015	In this paper, aluminum-free Mn-beta zeolite was hydrothermally synthesized in the SiO2-MnO2-(TEA)2O-NaF-H2O system.	Water	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
25298153-7	2015	Photodegradation was a major process removing the EDCs from the lake water, and the presence of dissolved organic material and NO3 (-) in the lake water can accelerate the photodegradation process.	Water	147-152	NBL1, DAN family BMP antagonist	Homo sapiens	127-130
25549320-0	2015	Spectroscopic investigation of the interaction of water-soluble azocalix[4]arenes with bovine serum albumin.	Water	50-55	albumin	Homo sapiens	94-107
25229693-6	2015	Interestingly, administration of AMPK activator metformin (200mg/kg/d, in drinking H2O for 4weeks) rescued against PTEN deletion-induced geometric and functional defects as well as interrupted autophagy and autophagic flux in the heart.	Water	83-86	phosphatase and tensin homolog	Mus musculus	115-119
25450770-1	2015	Here, I provide an overview of the solid-state characteristics, phase transformations and chemical reactions of metoclopramide hydrochloride monohydrate (MCP HCl H2O).	Water	162-165	CD46 molecule	Homo sapiens	154-157
25661386-10	2015	Water restriction decreased NOS activity in young and adult rats associated to an increased cav-1.	Water	0-5	caveolin 1	Rattus norvegicus	92-97
25450770-4	2015	I also report the exposure of MCP HCl H2O in solution to light, irradiation, oxidants or pi-acceptors.	Water	38-41	CD46 molecule	Homo sapiens	30-33
25271009-8	2015	Total AUC of insulin and c-peptide was similar in aspartame, sucralose and water settings.	Water	75-80	insulin	Homo sapiens	13-20
25271009-8	2015	Total AUC of insulin and c-peptide was similar in aspartame, sucralose and water settings.	Water	75-80	insulin	Homo sapiens	25-34
25271009-9	2015	Total AUC of GLP-1 was significantly higher in the sucralose setting than in the water setting (P=0.04).	Water	81-86	glucagon	Homo sapiens	13-18
25367751-1	2015	The synthetic TLR4 agonist glucopyranosyl lipid adjuvant (GLA) is a potent Th1-response-inducing adjuvant when formulated in a squalene oil-in-water emulsion (SE).	Water	143-148	toll-like receptor 4	Mus musculus	14-18
25404240-2	2015	We have investigated the effects of a water-soluble Zn-phthalocyanine, ZnPc(COONa)8, a macrocyclic compound with near-infrared optical properties, on Abeta fibril formation in vitro.	Water	38-43	amyloid beta precursor protein	Homo sapiens	150-155
25367751-7	2015	Thus, we demonstrate that IL-18 and caspase-1/11 are components of the response to immunization with the TLR4 agonist/squalene oil-in-water based adjuvant, GLA-SE, providing implications for other adjuvants that combine oils with TLR agonists.	Water	134-139	toll-like receptor 4	Mus musculus	105-109
25720087-0	2015	Natural mineral-rich water ingestion improves hepatic and fat glucocorticoid-signaling and increases sirtuin 1 in an animal model of metabolic syndrome.	Water	21-26	sirtuin 1	Rattus norvegicus	101-110
25180936-9	2015	Serum VEGF levels were correlated with water (rs = 0.363, p &lt; 0.001), hair (rs = 0.205, p &lt; 0.01) and nail (rs = 0.190, p &lt; 0.01) arsenic.	Water	39-44	vascular endothelial growth factor A	Homo sapiens	6-10
25180936-10	2015	Further, VEGF levels showed dose-response relationships with water, hair and nail arsenic.	Water	61-66	vascular endothelial growth factor A	Homo sapiens	9-13
25720087-7	2015	Mineral-rich water showed a trend towards a reduction of these fructose effects and significantly increased hepatic Sirt1 vs. CONT and FRUCT.	Water	13-18	sirtuin 1	Rattus norvegicus	116-121
25720087-10	2015	Mineral-rich water modulation of fructose effects on glucocorticoid-signaling and Sirt1 underlines the better metabolic profile found earlier.	Water	13-18	sirtuin 1	Rattus norvegicus	82-87
25594563-5	2015	By up-regulating the expression levels of AQP2, statins increase water reabsorption by the kidney, thus opening up a new avenue in treating patients with nephrogenic diabetes insipidus (NDI), a hereditary disease that yet lacks high-powered and limited side effects therapy.	Water	65-70	arginine vasopressin receptor 2	Homo sapiens	186-189
25652498-13	2015	In the perpendicular orientation, there is a shift in dose response relative to water in the highest dose gradient regions, at the edge of jaw-defined and single-segment MLC fields.	Water	80-85	modulator of VRAC current 1	Homo sapiens	170-173
25529427-2	2015	Of the aquaporins (AQP), which are a family of membrane-spanning proteins that are predominantly involved in the movement of water, AQP-3, AQP-7, and AQP-10 are also permeable to urea, but it is not clear if they contribute to urea transport across the ruminal epithelium.	Water	125-130	aquaporin-7	Bos taurus	139-144
25233074-1	2015	Aquaporin-3 (AQP3) is a water and glycerol channel expressed in epidermal keratinocytes.	Water	24-29	aquaporin 3	Mus musculus	0-11
25233074-1	2015	Aquaporin-3 (AQP3) is a water and glycerol channel expressed in epidermal keratinocytes.	Water	24-29	aquaporin 3	Mus musculus	13-17
25601796-10	2015	The water (W) tunnel is accessible to solvent during most of the simulations of CYP51, but its width is affected by the conformations of the heme"s two propionate groups.	Water	4-9	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	80-85
25592015-4	2015	Se was offered in the drinking water at a concentration of 11.18 mug/L.	Water	31-36	squalene epoxidase	Rattus norvegicus	0-2
25098892-7	2015	The dissemination of K. pneumoniae harboring blaVIM-1 in surface water is a cause for increased concern to public health.	Water	65-70	metallo-beta-lactamase VIM-1	Klebsiella pneumoniae	45-53
25489766-2	2015	Compound 1 exhibits a ladder-shaped chain with Sc2(pydc)2 units, which further construct a supramolecular characteristic with water molecules via hydrogen bond.	Water	126-131	trans-2,3-enoyl-CoA reductase	Homo sapiens	47-50
25878826-1	2015	The crystal structures of two solvates of fac-tri-chlorido-tris-(tri-methyl-phosphane-kappaP)rhodium(III) are reported, i.e. one with water in the crystal lattice, fac-[RhCl3(Me3P)3] H2O, and one with methanol in the crystal lattice, fac-[RhCl3(Me3P)3] 0.5CH3OH.	Water	134-139	FA complementation group C	Homo sapiens	42-45
25673989-3	2015	In this work, a nanocomplexation strategy was developed for modifying the stability and hemostatic efficacy of thrombin, in which a water-soluble cationic amylose derivative containing poly(l-lysine) dendrons was prepared by a click reaction and then used to complex thrombin in an aqueous system.	Water	132-137	coagulation factor II	Rattus norvegicus	111-119
25673989-3	2015	In this work, a nanocomplexation strategy was developed for modifying the stability and hemostatic efficacy of thrombin, in which a water-soluble cationic amylose derivative containing poly(l-lysine) dendrons was prepared by a click reaction and then used to complex thrombin in an aqueous system.	Water	132-137	coagulation factor II	Rattus norvegicus	267-275
25637961-4	2015	The water contact angles on the C18-Au, C8-AAO, C18-AAO, and C18-ZnO surfaces were measured to be 91.4 , 147.2 , 156.3 , and 157.8 , respectively.	Water	4-9	Bardet-Biedl syndrome 9	Homo sapiens	32-35
25637961-4	2015	The water contact angles on the C18-Au, C8-AAO, C18-AAO, and C18-ZnO surfaces were measured to be 91.4 , 147.2 , 156.3 , and 157.8 , respectively.	Water	4-9	Bardet-Biedl syndrome 9	Homo sapiens	48-51
25483018-3	2015	The results are compared with Cm(III) transferrin interaction at the C-lobe and indicate the similarity of the coordination environment of the C- and N-terminal binding sites with four amino acid residues of the protein, two H2O molecules and three additional ligands (e.g. synergistic anions such as carbonate) in the first coordination sphere.	Water	225-228	transferrin	Homo sapiens	38-49
25491543-4	2015	Our results clearly showed that the heart-type FABP (FABP3) preferentially incorporates a U-shaped FA of C10-C18 using a lipid-compatible water cluster, and excludes longer FAs using a chain-length-limiting water cluster.	Water	138-143	fatty acid binding protein 3	Homo sapiens	47-51
25637961-4	2015	The water contact angles on the C18-Au, C8-AAO, C18-AAO, and C18-ZnO surfaces were measured to be 91.4 , 147.2 , 156.3 , and 157.8 , respectively.	Water	4-9	Bardet-Biedl syndrome 9	Homo sapiens	48-51
32287446-0	2015	An efficient synthesis of 3-indolyl-3-hydroxy oxindoles and 3,3-di(indolyl)indolin-2-ones catalyzed by sulfonated beta-CD as a supramolecular catalyst in water.	Water	154-159	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	114-121
25491543-4	2015	Our results clearly showed that the heart-type FABP (FABP3) preferentially incorporates a U-shaped FA of C10-C18 using a lipid-compatible water cluster, and excludes longer FAs using a chain-length-limiting water cluster.	Water	138-143	fatty acid binding protein 3	Homo sapiens	53-58
32287446-1	2015	Sulfonated-beta-cyclodextrin (beta-CD-SO3H) promoted efficient and fast electrophilic substitution reaction of indoles with various isatins reflux in water is reported affording various 3-indolyl-3-hydroxy oxindoles and 3,3-di(indolyl)indolin-2-ones in good to excellent yields in short reaction time.	Water	150-155	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	30-37
25491543-4	2015	Our results clearly showed that the heart-type FABP (FABP3) preferentially incorporates a U-shaped FA of C10-C18 using a lipid-compatible water cluster, and excludes longer FAs using a chain-length-limiting water cluster.	Water	207-212	fatty acid binding protein 3	Homo sapiens	47-51
25491543-4	2015	Our results clearly showed that the heart-type FABP (FABP3) preferentially incorporates a U-shaped FA of C10-C18 using a lipid-compatible water cluster, and excludes longer FAs using a chain-length-limiting water cluster.	Water	207-212	fatty acid binding protein 3	Homo sapiens	53-58
25612721-1	2015	We perform molecular dynamics simulations to observe the structure and dynamics of SPC/E water in amorphous silica pores and amorphous ice pores with radii slightly larger than 10 A.	Water	89-94	proline rich protein gene cluster	Homo sapiens	83-86
25205244-2	2015	While microsecond MD simulations of FAAH in a realistic membrane/water environment provided a solid model for the reactant state of the enzymatic complex (Palermo et al.	Water	65-70	fatty acid amide hydrolase	Homo sapiens	36-40
25451293-5	2015	At 24 h after tMCAO, we measured neurological deficits, infarct volume, and brain water content, and found that neurological dysfunction, brain infarct size, and brain edema were worse in the Trx-1 siRNA group than in the control group.	Water	82-87	thioredoxin 1	Rattus norvegicus	192-197
25525817-1	2015	We present a study of the interaction of the positively charged model protein lysozyme with the negatively charged amphiphilic diblock polyelectrolyte micelles of poly(tert-butylstyrene-b-sodium (sulfamate/carboxylate)isoprene) (PtBS-b-SCPI) on the silver/water interface.	Water	256-261	lysozyme	Homo sapiens	78-86
25562373-6	2015	The pseudo-first-order reaction rate constants of Co(III) and Co(IV) with water were determined to be 0.19 and &gt;2 s(-1), respectively, through time-dependent titration measurements.	Water	74-79	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	50-57
25559259-6	2015	Starting from 3, the H-H sigma-bond is cleaved by the Ru and Ge-OH moieties to form [Dmp(Dep)(H2O)Ge(mu-S)Ru(H)(PPh3)](+) (4).	Water	94-97	caveolin 1	Homo sapiens	112-116
25559259-9	2015	Finally, the H2O dissociates from the Ge center to afford [Dmp(Dep)Ge(mu-S)Ru(H)(PPh3)](+) (PRD).	Water	13-16	caveolin 1	Homo sapiens	81-85
25559259-12	2015	In the Si analogue [Dmp(Dep)Si(mu-S)(mu-OH)Ru(PPh3)](+) (1Si), the isomerization of 1Si to 2Si easily occurs with a small activation energy, while the dissociation of H2O from the Si center needs a considerably large activation energy.	Water	167-170	caveolin 1	Homo sapiens	46-50
25582221-6	2015	An experimental rig was built to correlate the ultrasound images to high definition camera images of air bubbles created in water by an automatic bubbler system.	Water	124-129	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	16-19
25494642-1	2015	We report the synthesis of a perylene derivative (perylene tetracarboxylic di(propyl imidazole), abbreviated as PDI) that is coordinated with Co(II) ions to form a coordination polymer [PDI-Co(Cl)2(H2O)2]n (abbreviated as PDI-Co).	Water	198-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
25092571-5	2015	Next, we used a 10-day chronic stress paradigm to test whether 2-week deuterium-depleted water treatment (91 ppm) affects depressive-like behavior and hippocampal SERT.	Water	89-94	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	163-167
25092571-8	2015	In the chronic stress model, depressive-like features were reduced in mice fed with deuterium-depleted water, and SERT expression was decreased in mice treated with deuterium-treated water compared with regular water.	Water	183-188	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	114-118
25092571-8	2015	In the chronic stress model, depressive-like features were reduced in mice fed with deuterium-depleted water, and SERT expression was decreased in mice treated with deuterium-treated water compared with regular water.	Water	183-188	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	114-118
25415596-4	2015	Only the Small Angle Neutron Scattering (SANS) of concentrated toluene ACE solutions reveals the existence of small reverse micelles (probably ACE dimers forming small cages hosting 1-2 water molecules).	Water	186-191	angiotensin I converting enzyme	Homo sapiens	143-146
25406316-11	2015	These results suggest that the curvature of membranes coupled with an increase in water-accessible hydrophobic regions is important for binding and concentrating Abeta monomers, leading to amyloid nucleation.	Water	82-87	amyloid beta precursor protein	Homo sapiens	162-167
25007344-0	2015	Optimization of potent DFG-in inhibitors of platelet derived growth factor receptorbeta (PDGF-Rbeta) guided by water thermodynamics.	Water	111-116	platelet derived growth factor receptor beta	Homo sapiens	44-87
25007344-0	2015	Optimization of potent DFG-in inhibitors of platelet derived growth factor receptorbeta (PDGF-Rbeta) guided by water thermodynamics.	Water	111-116	platelet derived growth factor receptor beta	Homo sapiens	89-99
25489786-3	2015	In the present study, we performed molecular dynamics (MD) simulations on human heart-type fatty acid binding protein (FABP3), a typical iLBP that is highly expressed in heart and skeletal muscles, and showed that an altered mode of protein dynamics and rearrangement of the internal water cluster are key elements of ligand binding.	Water	284-289	fatty acid binding protein 3	Homo sapiens	80-117
25489786-3	2015	In the present study, we performed molecular dynamics (MD) simulations on human heart-type fatty acid binding protein (FABP3), a typical iLBP that is highly expressed in heart and skeletal muscles, and showed that an altered mode of protein dynamics and rearrangement of the internal water cluster are key elements of ligand binding.	Water	284-289	fatty acid binding protein 3	Homo sapiens	119-124
25007344-5	2015	Molecular modeling studies on a PDGF-Rbeta homology model using prediction of water thermodynamics suggested an optimization strategy for the 3,5-diaryl-pyrazin-2-ones as DFG-in binders by using a phenolic OH function to replace a structural water molecule in the ATP binding site.	Water	78-83	platelet derived growth factor receptor beta	Homo sapiens	32-42
25007344-5	2015	Molecular modeling studies on a PDGF-Rbeta homology model using prediction of water thermodynamics suggested an optimization strategy for the 3,5-diaryl-pyrazin-2-ones as DFG-in binders by using a phenolic OH function to replace a structural water molecule in the ATP binding site.	Water	242-247	platelet derived growth factor receptor beta	Homo sapiens	32-42
25025316-0	2015	Spectroscopic characterization and solubility investigation on the effects of As(V) on mineral structure tooeleite (Fe6(AsO3)2SO4(OH)2 H2O).	Water	135-138	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	78-83
24875192-7	2015	Notably, a variety of secreted paracrine and autocrine agents such as bradykinin, ATP, endothelin, nitric oxide, and prostaglandin E2 counterbalance and limit the natriferic effects of aldosterone and the water-retaining effects of AVP.	Water	205-210	kininogen 1	Homo sapiens	70-80
25483606-0	2015	Replacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT).	Water	15-20	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	110-139
25483606-0	2015	Replacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT).	Water	15-20	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	141-144
25448347-7	2015	We now show that our 500mum thick RHCIII-MPC constructs comprising over 85% water are suitable for microcontact printing with fibronectin.	Water	76-81	fibronectin 1	Homo sapiens	126-137
25926129-2	2015	Increased water intake to suppress vasopressin activity has been suggested as a potential renoprotective strategy.	Water	10-15	arginine vasopressin	Homo sapiens	35-46
26454581-5	2015	The cation-water correlation increases with the increasing rotational temperature if negative charge is placed in (or close to) the centre of the water molecule (a typical example is the SPC water model) and decreases, when the negative charge is shifted from the centre (as in the TIP5P model of water).	Water	11-16	proline rich protein gene cluster	Homo sapiens	187-190
26454581-5	2015	The cation-water correlation increases with the increasing rotational temperature if negative charge is placed in (or close to) the centre of the water molecule (a typical example is the SPC water model) and decreases, when the negative charge is shifted from the centre (as in the TIP5P model of water).	Water	146-151	proline rich protein gene cluster	Homo sapiens	187-190
26454581-5	2015	The cation-water correlation increases with the increasing rotational temperature if negative charge is placed in (or close to) the centre of the water molecule (a typical example is the SPC water model) and decreases, when the negative charge is shifted from the centre (as in the TIP5P model of water).	Water	146-151	proline rich protein gene cluster	Homo sapiens	187-190
26454581-5	2015	The cation-water correlation increases with the increasing rotational temperature if negative charge is placed in (or close to) the centre of the water molecule (a typical example is the SPC water model) and decreases, when the negative charge is shifted from the centre (as in the TIP5P model of water).	Water	146-151	proline rich protein gene cluster	Homo sapiens	187-190
26277928-2	2015	Spirulinaplatensis water extract reduced salicylate-induced overexpression of the Mn-SOD gene, but increased salicylate-induced downregulation of the CAT gene.	Water	19-24	superoxide dismutase 2, mitochondrial	Mus musculus	82-88
26088042-3	2015	Increased water intake may slow the progression of chronic kidney disease by lowering vasopressin levels.	Water	10-15	arginine vasopressin	Homo sapiens	86-97
26277928-2	2015	Spirulinaplatensis water extract reduced salicylate-induced overexpression of the Mn-SOD gene, but increased salicylate-induced downregulation of the CAT gene.	Water	19-24	catalase	Mus musculus	150-153
26176849-1	2015	Aquaporin 1 (AQP1), a member of water channel proteins, functions as a water-selective transporting protein in cell membranes.	Water	32-37	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
24794573-0	2015	Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: implications for membrane-water interfacial arginines.	Water	94-99	FXYD domain containing ion transport regulator 2	Homo sapiens	48-53
25921559-0	2015	A hot water extract of Curcuma longa inhibits adhesion molecule protein expression and monocyte adhesion to TNF-alpha-stimulated human endothelial cells.	Water	6-11	tumor necrosis factor	Homo sapiens	108-117
26176849-1	2015	Aquaporin 1 (AQP1), a member of water channel proteins, functions as a water-selective transporting protein in cell membranes.	Water	32-37	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
25112208-2	2015	A recently introduced octadecyl (C18) disk for semi-automated solid-phase extraction of PCDD/Fs in water samples with a high level of particulate material has been tested for the analysis of dioxins.	Water	99-104	Bardet-Biedl syndrome 9	Homo sapiens	33-36
25807645-5	2015	Only one of the 36 E. coli strains isolated from these five water samples was found to be extended spectrum beta lactamase (ESBL) positive.	Water	60-65	EsbL	Escherichia coli	90-122
25377276-0	2015	Development of second-generation small-molecule RhoA inhibitors with enhanced water solubility, tissue potency, and significant in vivo efficacy.	Water	78-83	ras homolog family member A	Homo sapiens	48-52
26073863-0	2015	CFTR Regulation of Aquaporin-Mediated Water Transport: A Target in Male Fertility.	Water	38-43	CF transmembrane conductance regulator	Homo sapiens	0-4
26073863-13	2015	Finally, we discuss the regulation of aquaporin-mediated water transport by CFTR in the male reproductive tract and its implication for male fertility.	Water	57-62	CF transmembrane conductance regulator	Homo sapiens	76-80
26135341-1	2015	In this study, the role of highly structured water molecules present in the active site of the leukotriene A4 hydrolase (LTA4H) enzyme has been critically examined through the docking experiments.	Water	45-50	leukotriene A4 hydrolase	Homo sapiens	95-119
26135341-1	2015	In this study, the role of highly structured water molecules present in the active site of the leukotriene A4 hydrolase (LTA4H) enzyme has been critically examined through the docking experiments.	Water	45-50	leukotriene A4 hydrolase	Homo sapiens	121-126
26728736-3	2015	GM damages caused by water immersion stress were accompanied by an increased transcription of TNFa.	Water	21-26	tumor necrosis factor	Homo sapiens	94-98
26202676-5	2015	Acute and chronic DSS colitis was induced by 3% DSS in drinking water in female Balb/c mice weighing 20-22 g. Recombinant gal-3 was expressed by the pET vector system and used for a 5-day treatment in different concentrations intraperitoneally.	Water	64-69	lectin, galactose binding, soluble 3	Mus musculus	122-127
25388457-3	2015	Their mechanism of action involves the adjustment of balance between vasoconstrictive, hypertrophic and salt/water-retentive angiotensin II and vasodilatory and natriuretic bradykinin by the inhibition of angiotensin II biosynthesis and bradykinin degradation.	Water	109-114	angiotensinogen	Homo sapiens	125-139
25190153-6	2015	The water-soluble vitamin B12 release from the compressed tablets was determined.	Water	4-9	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	26-29
27025048-8	2015	Azithromycin-induced increase in water absorption was associated with upregulation of AQP 8 water channel expression (P &lt; 0.05) in colonic mucosa.	Water	33-38	aquaporin 8	Rattus norvegicus	86-91
25454229-3	2015	The aim of this study was to determine the presence of endocrine activities dependent on the activation of human estrogen receptor alpha (hERa) and/or androgen receptor (hAR) in water in glass or plastic bottles sold to consumers in Southern Spain.	Water	178-183	estrogen receptor 1	Homo sapiens	113-136
25454229-3	2015	The aim of this study was to determine the presence of endocrine activities dependent on the activation of human estrogen receptor alpha (hERa) and/or androgen receptor (hAR) in water in glass or plastic bottles sold to consumers in Southern Spain.	Water	178-183	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	138-142
25454229-3	2015	The aim of this study was to determine the presence of endocrine activities dependent on the activation of human estrogen receptor alpha (hERa) and/or androgen receptor (hAR) in water in glass or plastic bottles sold to consumers in Southern Spain.	Water	178-183	androgen receptor	Homo sapiens	151-168
26236385-5	2015	Here, we show that KRG water extract increases the expression of TrxR1 in human umbilical vein endothelial cells via the p38 and PKC-delta signaling pathways.	Water	23-28	mitogen-activated protein kinase 14	Homo sapiens	121-124
26040034-3	2015	In experiments with rats we show that water-restrained stress was accompanied by a considerable increase of iNOS activity and intensity of lipoperoxidation processes.	Water	38-43	nitric oxide synthase 2	Rattus norvegicus	108-112
26040034-6	2015	Cyclooxygenese blockage with naproxen prior to induction of water-restrained stress was accompanied by the decease of iNOS in small and large intestines, with the synchronous rise of cNOS activity in the large intestine as compared with indexes in stress.	Water	60-65	nitric oxide synthase 2	Rattus norvegicus	118-122
26400662-0	2015	Water oxidation catalysis upon evolution of molecular Co(III) cubanes in aqueous media.	Water	0-5	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	54-61
26400662-6	2015	In this paper, we address the evolution of tetracobalt(III) cubanes, stabilised by a pyridine/acetate ligand pool, to active species that perform water oxidation to oxygen.	Water	146-151	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	55-58
27025048-8	2015	Azithromycin-induced increase in water absorption was associated with upregulation of AQP 8 water channel expression (P &lt; 0.05) in colonic mucosa.	Water	92-97	aquaporin 8	Rattus norvegicus	86-91
25316421-5	2015	Compared with DIP, P-DIP showed a satisfactory water-solubility and significant increase in the antioxidant properties.	Water	47-52	protein disulfide isomerase family A member 2	Homo sapiens	19-24
25368024-2	2015	We tested the hypothesis that striatin would in turn affect mineralocorticoid receptor function and consequently sodium, water, and blood pressure homeostasis in an animal model.	Water	121-126	striatin, calmodulin binding protein	Mus musculus	30-38
25316421-6	2015	Moreover, P-DIP also showed more significant inhibitory effects on the growth of MCF-7 and B16 tumor cells than the water-insoluble DIP.	Water	116-121	protein disulfide isomerase family A member 2	Homo sapiens	10-15
25758076-2	2015	Hot tub lung is a granulomatous lung disease caused by the inhalation of water aerosols containing non-tuberculous mycobacteria.	Water	73-78	TUB bipartite transcription factor	Homo sapiens	4-7
25841369-7	2015	The applicability of the PPy-g-Ch has been tested for the removal of Pb(II) and Cd(II) ions from a real water sample spiked with Pb(II) and Cd(II) ions.	Water	104-109	submaxillary gland androgen regulated protein 3B	Homo sapiens	69-86
26839549-4	2015	Optimized PLSR models were successfully built and used for on-line detecting of the concentrations of DSS, PA, RA, and SAB of water precipitation during Danhong injection.	Water	126-131	SH3 domain binding protein 5	Homo sapiens	119-122
25876951-8	2015	TLX teeth demonstrated a hardness reduction of 28.96% of both layers for all solutions including water (p&lt;0.0000).	Water	97-102	CD46 molecule	Homo sapiens	0-3
25633675-1	2015	BACKGROUND: We previously showed that a water extract of the medicinal plant Centella asiatica (CAW) attenuates amyloid-beta (Abeta)-induced cognitive deficits in vivo, and prevents Abeta-induced cytotoxicity in vitro.	Water	40-45	amyloid beta precursor protein	Homo sapiens	126-131
25633675-1	2015	BACKGROUND: We previously showed that a water extract of the medicinal plant Centella asiatica (CAW) attenuates amyloid-beta (Abeta)-induced cognitive deficits in vivo, and prevents Abeta-induced cytotoxicity in vitro.	Water	40-45	amyloid beta precursor protein	Homo sapiens	182-187
25114080-4	2015	In this study, we found that the long-term overexpression of HO-1 led to cognitive decline in transgenic mice, as determined by the water maze test, and that HO-1 can affect two pathways for tauopathy.	Water	132-137	heme oxygenase 1	Mus musculus	61-65
25431827-5	2015	A DBP content of 80 wt% marked the best water absorption performance and the highest cell viability.	Water	40-45	D-box binding PAR bZIP transcription factor	Homo sapiens	2-5
24341417-10	2015	CONCLUSION: Although BPT using high-concentrated salt water solutions is associated with increased epidermal COX-2 mRNA expression, apoptosis of keratinocytes is enhanced possibly due to the down-regulation of survivin mRNA expression.	Water	54-59	prostaglandin-endoperoxide synthase 2	Homo sapiens	109-114
25589236-0	2015	Simultaneous ultrasound-assisted water extraction and beta-cyclodextrin encapsulation of polyphenols from Mangifera indica stem bark in counteracting TNFalpha-induced endothelial dysfunction.	Water	33-38	tumor necrosis factor	Homo sapiens	150-158
26877636-2	2015	After removal of the milk protein and fats by chloroform extraction and centrifugation, the vitamin B12 was water extracted from the sample.	Water	108-113	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	100-103
26596112-3	2015	In oral intake of hyperchlorination drinkable water products, the study revealed main genes having polymorphism associated with endocrine disorders: overweight and obesity--APOE, PPARG, HTR2A, characterizing antioxidant system state--SOD2 and detoxication--SULTA.	Water	46-51	apolipoprotein E	Homo sapiens	173-177
26596112-3	2015	In oral intake of hyperchlorination drinkable water products, the study revealed main genes having polymorphism associated with endocrine disorders: overweight and obesity--APOE, PPARG, HTR2A, characterizing antioxidant system state--SOD2 and detoxication--SULTA.	Water	46-51	peroxisome proliferator activated receptor gamma	Homo sapiens	179-184
26596112-3	2015	In oral intake of hyperchlorination drinkable water products, the study revealed main genes having polymorphism associated with endocrine disorders: overweight and obesity--APOE, PPARG, HTR2A, characterizing antioxidant system state--SOD2 and detoxication--SULTA.	Water	46-51	5-hydroxytryptamine receptor 2A	Homo sapiens	186-191
25438126-4	2015	In this region, water contained total arsenic concentrations up to 1250 mug L(-1), which was almost exclusively As(V).	Water	16-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	112-117
25697519-0	2015	Detection of structural waters and their role in structural dynamics of rhodopsin activation.	Water	24-30	rhodopsin	Homo sapiens	72-81
25697519-2	2015	Radiolysis-based hydroxyl radical footprinting (HRF) strategies coupled to mass spectrometry have been used to explore the structural waters within rhodopsin in multiple signaling states.	Water	134-140	rhodopsin	Homo sapiens	148-157
25926290-1	2015	BACKGROUND/AIMS: Tolvaptan, a vasopressin V2 receptor antagonist, promotes the excretion of electrolyte-free water.	Water	109-114	arginine vasopressin receptor 2	Homo sapiens	30-53
27443003-10	2015	After those procedures water and alcohol extracts of nettle were prepared and then added to THP1 cells.	Water	23-28	GLI family zinc finger 2	Homo sapiens	92-96
25323423-3	2015	Control rat dams consumed tap water without added Mn.	Water	30-35	nuclear RNA export factor 1	Rattus norvegicus	26-29
27443003-12	2015	The study showed that both extracts (water and alcohol) significantly increased the antioxidant activity of catalase in THP1 cells.	Water	37-42	GLI family zinc finger 2	Homo sapiens	120-124
26347850-9	2015	The protective effect of QP water extract was found to be via inhibiting MEK/ERK pathway and reversing PI3-K/Akt/GSK3beta pathway.	Water	28-33	Eph receptor B1	Rattus norvegicus	77-80
26347850-9	2015	The protective effect of QP water extract was found to be via inhibiting MEK/ERK pathway and reversing PI3-K/Akt/GSK3beta pathway.	Water	28-33	AKT serine/threonine kinase 1	Rattus norvegicus	109-112
27443003-12	2015	The study showed that both extracts (water and alcohol) significantly increased the antioxidant activity of catalase in THP1 cells.	Water	37-42	catalase	Homo sapiens	108-116
25304213-2	2015	PON1 hydrolyzes some organophosphates (OPs), including some nerve agents, through nucleophilic attack of hydroxide ion (from water) in the active site.	Water	125-130	paraoxonase 1	Homo sapiens	0-4
25449712-12	2015	DISCUSSION: Our results suggest that the IL-6 and CRP contribute to impaired anisotropy of water diffusion in selected pathways that have been previously associated with schizophrenia suggesting differential susceptibility of selected neural pathways to immune mediators.	Water	91-96	interleukin 6	Homo sapiens	41-45
25449712-12	2015	DISCUSSION: Our results suggest that the IL-6 and CRP contribute to impaired anisotropy of water diffusion in selected pathways that have been previously associated with schizophrenia suggesting differential susceptibility of selected neural pathways to immune mediators.	Water	91-96	C-reactive protein	Homo sapiens	50-53
25467533-4	2015	Important for establishing the validity of these rules in both series B ICl and B ICF3 were the complexes with B = H2O or H2S.	Water	115-118	cell division cycle associated 7	Homo sapiens	82-86
25278460-1	2015	Beside its hormonal function in salt and water homeostasis, vasopressin released into distinct brain areas plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state.	Water	41-46	arginine vasopressin	Rattus norvegicus	60-71
25467533-5	2015	The configuration at O in H2O ICF3 and H2O ICl is effectively planar.	Water	26-29	cell division cycle associated 7	Homo sapiens	30-34
25743892-9	2015	A DNA interface of MBD4 has flexible structural features, in which an extensive hydration water network supports the versatile base specificity of MBD4.	Water	90-95	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	19-23
25069890-9	2015	Natural water showed an interesting effect: for a low concentration of DXC (6.4muM), an improvement in the degradation process was observed, while at a higher concentration of DXC (0.43mM), degradation was inhibited.	Water	8-13	latexin	Homo sapiens	79-82
25633940-3	2015	The PAEs were detected with total concentrations (Sigma6PAEs) ranging from 0.35 to 20.70 mug L-1 in surface water and dry weight ranging from 0.88 to 5.69 mug g-1 in sediments.	Water	108-113	immunoglobulin kappa variable 1-16	Homo sapiens	93-96
25677777-1	2015	The neuropeptide nociceptin/orphanin FQ (N/OFQ), acting on its receptors (NOP), modulates a variety of biological functions and neurobehavior including nociception, stress responses, water and food-intake, locomotor activity, and spatial attention.	Water	183-188	prepronociceptin	Homo sapiens	17-27
25677777-1	2015	The neuropeptide nociceptin/orphanin FQ (N/OFQ), acting on its receptors (NOP), modulates a variety of biological functions and neurobehavior including nociception, stress responses, water and food-intake, locomotor activity, and spatial attention.	Water	183-188	prepronociceptin	Homo sapiens	28-39
25677777-1	2015	The neuropeptide nociceptin/orphanin FQ (N/OFQ), acting on its receptors (NOP), modulates a variety of biological functions and neurobehavior including nociception, stress responses, water and food-intake, locomotor activity, and spatial attention.	Water	183-188	prepronociceptin	Homo sapiens	41-46
25817873-1	2015	Vasopressin is the main hormone that regulates water conservation in mammals and one of its major targets is the principal cells in the renal collecting duct.	Water	47-52	arginine vasopressin	Homo sapiens	0-11
25817873-2	2015	Vasopressin increases the apical water permeability of principal cells, mediated by apical accumulation of aquaporin-2 (AQP2), a water channel protein, thus facilitating water reabsorption by the kidney.	Water	33-38	arginine vasopressin	Homo sapiens	0-11
25817873-2	2015	Vasopressin increases the apical water permeability of principal cells, mediated by apical accumulation of aquaporin-2 (AQP2), a water channel protein, thus facilitating water reabsorption by the kidney.	Water	129-134	arginine vasopressin	Homo sapiens	0-11
25817873-2	2015	Vasopressin increases the apical water permeability of principal cells, mediated by apical accumulation of aquaporin-2 (AQP2), a water channel protein, thus facilitating water reabsorption by the kidney.	Water	129-134	arginine vasopressin	Homo sapiens	0-11
25743892-9	2015	A DNA interface of MBD4 has flexible structural features, in which an extensive hydration water network supports the versatile base specificity of MBD4.	Water	90-95	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	147-151
25380330-3	2014	This study is one step forward in the development of a new class of water-soluble catalase mimics.	Water	68-73	catalase	Homo sapiens	82-90
25311178-9	2014	Compared with 2003, the water content of DP-1 decreased by about 14.1% (from 15.6 to 13.4 mol), and the MBC of DP-1 decreased by about 12.5% (from 714 to 625 mg/g) at pH 7.5.	Water	24-29	transcription factor Dp-1	Homo sapiens	41-45
25380325-0	2014	The structure of insulin at the air/water interface: monomers or dimers?	Water	36-41	insulin	Homo sapiens	17-24
25380325-1	2014	The hydrophobic character of the air/water interface affects the oligomeric composition of insulin.	Water	37-42	insulin	Homo sapiens	91-98
25380325-2	2014	By using interface-specific vibrational sum frequency spectroscopy and calculations of insulin monomer and dimer second-order nonlinear susceptibilities chi((2)), we show that insulin monomers segregate to the air/water interface.	Water	214-219	insulin	Homo sapiens	176-183
25382711-2	2014	The mononuclear derivative binds human serum albumin (HSA) with an association constant of 3372 M(-1), which results in the replacement of the coordinated water molecules by donor atoms of protein residues.	Water	155-160	albumin	Homo sapiens	39-52
32262006-2	2014	This study exploited a folate-decorated delivery of bexarotene-loaded bovine serum albumin nanoparticles, which could solubilize the poorly water-soluble drug and overcome the nonspecific targeting disadvantage.	Water	140-145	albumin	Homo sapiens	77-90
27800366-1	2014	Vitamin B12 is a water-soluble molecule composed of a tetrapyrrolic complex with a cobalt atom at its centre.	Water	17-22	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
25522362-2	2014	During the onset of autophagy, the water-soluble protein Atg8 binds covalently to phosphatdylethanolamines (PEs) in the membrane in an ubiquitin-like reaction coupled to ATP hydrolysis.	Water	35-40	GABA type A receptor associated protein like 1	Homo sapiens	57-61
25423999-7	2014	Interestingly, the nanofibers exhibit a reversible transformation of the coordination geometry of the Co(II) ions between octahedral and pseudotetrahedral with a concomitant color change between pink and blue, which involves the loss and reuptake of unusual weakly coordinated water molecules without destroying the structure.	Water	277-282	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
25407218-0	2014	Water oxidation catalysis by Co(II) impurities in Co(III)4O4 cubanes.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
25407218-1	2014	The observed water oxidation activity of the compound class Co4O4(OAc)4(Py-X)4 emanates from a Co(II) impurity.	Water	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
25407218-3	2014	We present results from electron paramagnetic resonance spectroscopy, nuclear magnetic resonance line broadening analysis, and electrochemical titrations to establish the existence of the Co(II) impurity as the major source of water oxidation activity that has been reported for Co4O4 molecular cubanes.	Water	227-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-194
25449061-1	2014	The aim of the present study aimed to investigate whether glycated bovine serum albumin (BSA) showed novel activities on the lipid-water interface.	Water	131-136	albumin	Homo sapiens	74-87
25548615-5	2014	When bound to the V1a and/or V2 receptors, vasopressin causes vasoconstriction, left ventricular remodeling and free water reabsorption.	Water	117-122	arginine vasopressin	Homo sapiens	43-54
25038684-5	2014	The results suggest that HSP90 may play a crucial role in water retention of meat and may be involved in postmortem meat quality development.	Water	58-63	heat shock protein HSP 90-alpha	Sus scrofa	25-30
25324517-3	2014	Four electrons are required for the reduction of oxygen to water, and these are provided by the one-electron donor, cytochrome c.	Water	59-64	cytochrome c, somatic	Homo sapiens	116-128
25324518-4	2014	Cytochrome c oxidase is responsible for reduction of molecular oxygen to water using reducing equivalents donated by cytochrome c and for site 3 energy coupling in oxidative phosphorylation.	Water	73-78	cytochrome c, somatic	Homo sapiens	0-12
25324518-4	2014	Cytochrome c oxidase is responsible for reduction of molecular oxygen to water using reducing equivalents donated by cytochrome c and for site 3 energy coupling in oxidative phosphorylation.	Water	73-78	cytochrome c, somatic	Homo sapiens	117-129
26501459-1	2014	BACKGROUND: The current MR-based attenuation correction (AC) used in combined PET/MR systems computes a Dixon attenuation map (MR-ACDixon) based on fat and water images derived from in- and opposed-phase MRI.	Water	156-161	ATPase, class II, type 9B	Mus musculus	24-26
25503313-4	2014	We show for the first time that the enzymatic activity depends on pH values and metal ions via the bond length of the nearest coordinating water (Wat1) to the metal ion.	Water	139-144	MTOR associated protein, LST8 homolog	Homo sapiens	146-150
25434010-6	2014	The finding of aquaglyceroporin-9 in the basolateral surface of the hepatocyte accounted for the rapid entry of mannitol into hepatocytes and its exclusion from water movement in the ductules where aquaporin-1 is present.	Water	161-166	aquaporin 9	Homo sapiens	15-33
25194329-10	2014	Generally speaking, the results support the premise that problems associated with implementing treatment that removes DBP precursors in water submitted to chlorination can increase population exposure to these contaminants in small systems.	Water	136-141	D-box binding PAR bZIP transcription factor	Homo sapiens	118-121
25440191-5	2014	Equilibrium with water phase may notably contribute in controlling the PCB levels in the plankton.	Water	17-22	pyruvate carboxylase	Homo sapiens	71-74
25517693-3	2014	Under optimized conditions, the linear response of P (2 muM) toward Cu2+ was 0.05-0.9 muM in ethanol-water solution (3:2, v:v, 50 mM HEPES, pH 7.4), and the detection limit was 0.03 muM.	Water	101-106	latexin	Homo sapiens	56-59
25517693-3	2014	Under optimized conditions, the linear response of P (2 muM) toward Cu2+ was 0.05-0.9 muM in ethanol-water solution (3:2, v:v, 50 mM HEPES, pH 7.4), and the detection limit was 0.03 muM.	Water	101-106	latexin	Homo sapiens	86-89
25517693-3	2014	Under optimized conditions, the linear response of P (2 muM) toward Cu2+ was 0.05-0.9 muM in ethanol-water solution (3:2, v:v, 50 mM HEPES, pH 7.4), and the detection limit was 0.03 muM.	Water	101-106	latexin	Homo sapiens	86-89
24960108-2	2014	Two n-propanol molecules and one water molecule coordinate to three Co(II) ions and four mu-phenoxo oxygen atoms from two [CoL(CH3CH2CH2OH)] units also coordinating to Co(II) ion.	Water	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
24960108-2	2014	Two n-propanol molecules and one water molecule coordinate to three Co(II) ions and four mu-phenoxo oxygen atoms from two [CoL(CH3CH2CH2OH)] units also coordinating to Co(II) ion.	Water	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
24996211-0	2014	Affinity to bovine serum albumin and anticancer activity of some new water-soluble metal Schiff base complexes.	Water	69-74	albumin	Homo sapiens	19-32
25383488-2	2014	By grinding the hydrophobic molecule with the amyloidogenic protein insulin, we obtained a water-soluble composite material.	Water	91-96	insulin	Homo sapiens	68-75
25479611-6	2014	In the flowing phase (water effluent), AOA diversity was significantly correlated with the concentration of dissolve oxygen (DO), NO3-N and NH3-N.	Water	22-27	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
24988986-1	2014	Tolvaptan is a competitive vasopressin V2-receptor antagonist that inhibits water reabsorption in the renal collecting ducts.	Water	76-81	arginine vasopressin receptor 2	Rattus norvegicus	27-50
26336722-7	2014	The CRP level was influenced by % fat and % water in the low body fat group and in females.	Water	44-49	C-reactive protein	Homo sapiens	4-7
25211589-8	2014	Emerging concepts of receptors and of genetic analysis led to the recognition of patients with mutations in the genes for 1) arginine vasopressin (AVP), 2) the AVP receptor 2 (AVPR2), and 3) the aquaporin 2 water channel (AQP2).	Water	207-212	arginine vasopressin	Homo sapiens	134-145
25211589-8	2014	Emerging concepts of receptors and of genetic analysis led to the recognition of patients with mutations in the genes for 1) arginine vasopressin (AVP), 2) the AVP receptor 2 (AVPR2), and 3) the aquaporin 2 water channel (AQP2).	Water	207-212	arginine vasopressin receptor 2	Homo sapiens	176-181
26501459-2	2014	We observed an occasional fat/water inversion in MR-ACDixon.	Water	30-35	ATPase, class II, type 9B	Mus musculus	49-51
25478871-8	2014	Although water immersion had a small but significant effect upon NIR light intensity, this resulted in a negligible change in the measured TSI (%).	Water	9-14	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	65-68
24125055-4	2014	The affibody Z(HER2:342) alone and in complex with HER2 was energetically minimized, solvated in explicit water, and neutralized.	Water	106-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	15-19
24125055-4	2014	The affibody Z(HER2:342) alone and in complex with HER2 was energetically minimized, solvated in explicit water, and neutralized.	Water	106-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	51-55
25202818-1	2014	CONTEXT: Vasopressin plays a central role in water homeostasis but it has also been recognized to be associated with adverse effects in several chronic diseases.	Water	45-50	arginine vasopressin	Homo sapiens	9-20
25308627-0	2014	Oral delivery of highly lipophilic poorly water-soluble drugs: spray-dried dispersions to improve oral absorption and enable high-dose toxicology studies of a P2Y1 antagonist.	Water	42-47	purinergic receptor P2Y1	Rattus norvegicus	159-163
25208977-2	2014	As downregulation of hepatocyte canalicular aquaporin-8 (AQP8) water channels has been involved in estrogen-induced bile secretory failure, we tested whether the archetypal water channel AQP1 improves 17alpha-ethinylestradiol (EE)-induced cholestasis.	Water	63-68	aquaporin 8	Rattus norvegicus	57-61
25208977-9	2014	Our data suggest that the adenoviral transfer of hAQP1 gene to the livers of EE-induced cholestatic rats improves bile flow by enhancing the AQP-mediated bile salt-induced canalicular water secretion.	Water	184-189	aquaporin 1 (Colton blood group)	Homo sapiens	49-54
25467201-4	2014	Treatment with 100 mug/ml ethyl acetate fraction (REF), which was isolated from water extract of the seeds, significantly inhibited LPS-stimulated production of nitric oxide (P &lt; 0.05), interleukin-6 (P &lt; 0.001), and tumor necrosis factor (TNF)-alpha (P &lt; 0.001) in RAW264.7 cells.	Water	80-85	interleukin 6	Mus musculus	189-202
25312395-14	2014	This study also highlights the role of conserved water molecules in the active site of Chk1 for the successful identification of novel inhibitors.	Water	49-54	checkpoint kinase 1	Homo sapiens	87-91
25323950-2	2014	The aim of the present study was to investigate the inhibitory effect of SCRT water extract and its 13 constituent components on chemokine and enzyme production in the human bronchial epithelium cell line BEAS-2B when induced by tumor necrosis factor-alpha and interleukin-4.	Water	78-83	tumor necrosis factor	Homo sapiens	229-256
25253781-9	2014	Structural modeling of the A687V EZH2 active site suggests that the increased catalytic activity with H3K27me1 may be due to a weakened interaction with an active site water molecule that must be displaced for dimethylation to occur.	Water	168-173	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	33-37
25323950-4	2014	The SCRT water extract demonstrated a dose-dependent inhibition of RANTES, eotaxin, eotaxin-3 and matrix metalloproteinase-9 (MMP-9) in BEAS-2B cells.	Water	9-14	C-C motif chemokine ligand 11	Homo sapiens	75-82
32261913-7	2014	It can be used to detect concentrations of Cu2+ as low as 30 muM in river water by observation with the naked eye and of 1.55 muM Cu2+ in river water by UV-visible spectrophotometry, within 10 min and with a recovery of 98-103% and a relative standard deviation (RSD) < 4% (n = 6).	Water	74-79	latexin	Homo sapiens	61-64
25144891-5	2014	Thrombin caused significant edema at 24 hours (~ 5% increase in water) that was not mitigated by whole-body or brain-selective cooling.	Water	64-69	coagulation factor II	Rattus norvegicus	0-8
25292256-3	2014	A beta-hairpin conformation was found for all peptides at the air-water interface although their packing arrangements seem to be different.	Water	66-71	amyloid beta precursor protein	Homo sapiens	0-6
32261913-7	2014	It can be used to detect concentrations of Cu2+ as low as 30 muM in river water by observation with the naked eye and of 1.55 muM Cu2+ in river water by UV-visible spectrophotometry, within 10 min and with a recovery of 98-103% and a relative standard deviation (RSD) < 4% (n = 6).	Water	144-149	latexin	Homo sapiens	126-129
25329565-7	2014	The preconcentration of Pb(II) ions is based on dispersive micro solid-phase extraction in which the suspended GO-NH2 is rapidly injected into analyzed water sample.	Water	152-157	submaxillary gland androgen regulated protein 3B	Homo sapiens	24-30
24984185-1	2014	Ice lenses are formed during soil freezing by the migration and solidification of premelted water that is adsorbed to ice-particle interfaces and confined to capillary regions.	Water	92-97	carboxylesterase 2	Homo sapiens	0-3
25329565-10	2014	The GO-NH2 is characterized by high selectivity toward Pb(II) ions and can be successfully used for analysis of various water samples with excellent enrichment factors of 100 and detection limits of 9.4 ng L(-1).	Water	120-125	submaxillary gland androgen regulated protein 3B	Homo sapiens	55-61
24984185-1	2014	Ice lenses are formed during soil freezing by the migration and solidification of premelted water that is adsorbed to ice-particle interfaces and confined to capillary regions.	Water	92-97	carboxylesterase 2	Homo sapiens	118-121
25168282-4	2014	The uptake of 1.2 muM TCA by cRNA-injected oocytes increased more than 100-fold compared to H2O-injected oocytes, indicating that hNTCP is robustly expressed in the oocytes.	Water	92-95	solute carrier family 10 member 1	Homo sapiens	130-135
24607774-6	2014	However, various animal studies indicate that blocking the renal tubular ETAR and ETBR causes water and salt retention partially mediated via the epithelial sodium transporter in tubular cells.	Water	94-99	endothelin receptor type B	Homo sapiens	82-86
25477821-3	2014	In addition, inactivation of the LPBN induces overdrinking of water in response to a range of dipsogenic treatments primarily, but not exclusively, those associated with endogenous centrally acting angiotensin II.	Water	62-67	angiotensinogen	Homo sapiens	198-212
24914851-5	2014	The nanoprobe exhibits good water dispersivity, biocompatibility and cell permeability, high selectivity over competing metal ions, and high sensitivity with a detection limit as low as 0.5 muM.	Water	28-33	latexin	Homo sapiens	190-193
24951924-12	2014	The method showed appropriate capability for TNT analysis in real water samples.	Water	66-71	chromosome 16 open reading frame 82	Homo sapiens	45-48
25259383-2	2014	In the present contribution, we have addressed the issue of whether the collective hydrogen bond dynamics of water gets perturbed in the presence of GdmCl and its possible impact on the denaturation of a globular protein human serum albumin (HSA), using terahertz (THz) time domain spectroscopy (TTDS) in the frequency range of 0.3-2.0 THz.	Water	109-114	albumin	Homo sapiens	227-240
25291259-2	2014	The steady-state fluorescence spectra showed that the I1/I3 ratio decreased from 1.73 +- 0.06 for SDS concentration smaller than 2 mM where pyrene was exposed to water to 1.43 +- 0.03 for SDS concentration greater than 6 mM where pyrene was incorporated inside SDS micelles.	Water	162-167	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	54-59
25399172-3	2014	In this report, we present the measurement of changes of the orientational angle of the "free OH" group at the air/water interface of the sodium fluoride (NaF) solutions at different concentrations using the interface selective sum-frequency generation vibrational spectroscopy (SFG-VS) in the ssp and ppp polarizations.	Water	115-120	C-X-C motif chemokine ligand 8	Homo sapiens	155-158
25399172-6	2014	These results provide quantitative molecular details of the ion effects of the NaF salt on the structure of the water molecules at the top-most layer of the air/water interface, even though both the Na(+) cation and the F(-) anion are believed to be among the most excluded ions from the air/water interface.	Water	112-117	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
25399172-6	2014	These results provide quantitative molecular details of the ion effects of the NaF salt on the structure of the water molecules at the top-most layer of the air/water interface, even though both the Na(+) cation and the F(-) anion are believed to be among the most excluded ions from the air/water interface.	Water	161-166	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
25399172-6	2014	These results provide quantitative molecular details of the ion effects of the NaF salt on the structure of the water molecules at the top-most layer of the air/water interface, even though both the Na(+) cation and the F(-) anion are believed to be among the most excluded ions from the air/water interface.	Water	161-166	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
25399194-0	2014	Homogeneous ice nucleation evaluated for several water models.	Water	49-54	carboxylesterase 2	Homo sapiens	12-15
25399194-1	2014	In this work, we evaluate by means of computer simulations the rate for ice homogeneous nucleation for several water models such as TIP4P, TIP4P/2005,TIP4P/ICE, and mW (following the same procedure as in Sanz et al.	Water	111-116	carboxylesterase 2	Homo sapiens	72-75
25399194-7	2014	We estimate the ice-liquid interfacial free-energy, and conclude that for all water models gamma decreases as the temperature decreases.	Water	78-83	carboxylesterase 2	Homo sapiens	16-19
25381497-4	2014	Specifically, we show that experimental data for dye molecules in several solvents, amino acid proteins in water, and some photochemical systems (e.g., rhodopsin and green fluorescence proteins), are well described by a three-parameter family of sub-Ohmic spectral densities that are characterized by a fast initial Gaussian-like decay followed by a slow algebraic-like decay rate at long times.	Water	107-112	rhodopsin	Homo sapiens	152-161
25137639-0	2014	Role of Pb(II) defects in the mechanism of dissolution of plattnerite (beta-PbO2) in water under depleting chlorine conditions.	Water	85-90	submaxillary gland androgen regulated protein 3B	Homo sapiens	8-14
25374825-2	2014	Mediators that play a significant role in regulating the transport of solutes and water include angiotensin II (AngII) and nitric oxide (NO).	Water	82-87	angiotensinogen	Homo sapiens	96-110
25374825-2	2014	Mediators that play a significant role in regulating the transport of solutes and water include angiotensin II (AngII) and nitric oxide (NO).	Water	82-87	angiotensinogen	Homo sapiens	112-117
25489227-16	2014	Accordingly, the rd10 EE mice at 1 year of age were still capable of performing the visual water task in photopic conditions, showing a residual visual acuity of 0.138+-0 cycles/degree.	Water	91-96	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	17-21
25374805-5	2014	Increased levels of antidiuretic hormone can result in hyponatremia, defined as a plasma sodium level &lt; 136 mmol/L, which causes cells to draw in excess water and swell.	Water	156-161	arginine vasopressin	Homo sapiens	20-40
25113195-2	2014	Although many treatment approaches have been demonstrated to result in degradation of PCBs in water or water/cosolvent systems, few examples exist where such approaches have been applied successfully for PCB degradation in soil-water systems.	Water	94-99	pyruvate carboxylase	Homo sapiens	86-89
25322447-4	2014	This species is a diprotic acid with the conjugate bases [Fe2(mu-O)(TPA)2(H2O)(OH)](+3) (1b; log beta = 15.53(6)) and [Fe2(mu-O)(TPA)2(OH)2](+2) (1c; log beta = 10.27(7)).	Water	74-77	plasminogen activator, tissue type	Homo sapiens	68-71
25322447-12	2014	The addition of phenol to 1 facilitates acidic cleavage of the mu-oxo dimer to form [Fe(TPA)(OPh)(H2O)](+2), which becomes the dominant iron(III)-phenoxide as the pH decreases to 4.	Water	98-101	plasminogen activator, tissue type	Homo sapiens	88-91
25120187-4	2014	PHD2 forms a stable complex with Fe(II) and 2OG; crystallographic and kinetic analyses indicate that an Fe(II)-co-ordinated water molecule, which must be displaced before O2 binding, is relatively stable in the active site of PHD2.	Water	124-129	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
25120187-4	2014	PHD2 forms a stable complex with Fe(II) and 2OG; crystallographic and kinetic analyses indicate that an Fe(II)-co-ordinated water molecule, which must be displaced before O2 binding, is relatively stable in the active site of PHD2.	Water	124-129	egl-9 family hypoxia inducible factor 1	Homo sapiens	226-230
22370872-0	2014	Effect of two Chinese medicinal compounds, blood-activating and water-draining medicine, on tumor necrosis factor alpha and nuclear factor kappa B expressions in rats with intracerebral hemorrhage.	Water	64-69	tumor necrosis factor	Rattus norvegicus	92-119
22370872-1	2014	OBJECTIVE: To investigate the effect of blood-activating Chinese medicinal compounds and water-draining Chinese medicinal compounds on tumor necrosis factor alpha (TNF-alpha) and nuclear factor kappaB (NF-kappa B) expressions in rats with intracerebral hemorrhage (ICH) at the acute stage, and to monitor their therapeutic effect and mechanism of action on inflammation and cerebral edema.	Water	89-94	tumor necrosis factor	Rattus norvegicus	135-162
22370872-1	2014	OBJECTIVE: To investigate the effect of blood-activating Chinese medicinal compounds and water-draining Chinese medicinal compounds on tumor necrosis factor alpha (TNF-alpha) and nuclear factor kappaB (NF-kappa B) expressions in rats with intracerebral hemorrhage (ICH) at the acute stage, and to monitor their therapeutic effect and mechanism of action on inflammation and cerebral edema.	Water	89-94	tumor necrosis factor	Rattus norvegicus	164-173
25217463-8	2014	In contrast, SEC6, a protein of the exocyst complex that is required for the water expulsion step, and a dynamin-like protein are upregulated under strong hypotonic conditions.	Water	77-82	uncharacterized protein	Chlamydomonas reinhardtii	13-17
25560206-0	2014	Stimulation of glucagon-like peptide-1 secretion by water loading in human.	Water	52-57	glucagon	Homo sapiens	15-38
25493180-3	2014	Using ovariectomized (OVX) osteoporosis mice model, we investigated the effects of LPSp on the bone density and Ca concentration after ingesting LPSp-containing water for 4 weeks.	Water	161-166	toll-like receptor 4	Mus musculus	145-149
24997241-7	2014	Intrastriatal injections of Tet-On lentivirus vectors resulted in dramatically increased levels of hGDNF protein in the striatum of rats with Dox-drinking water, when compared to lentivirus-injected and saline-injected rats with normal drinking water, respectively.	Water	155-160	glial cell derived neurotrophic factor	Homo sapiens	99-104
24997241-7	2014	Intrastriatal injections of Tet-On lentivirus vectors resulted in dramatically increased levels of hGDNF protein in the striatum of rats with Dox-drinking water, when compared to lentivirus-injected and saline-injected rats with normal drinking water, respectively.	Water	245-250	glial cell derived neurotrophic factor	Homo sapiens	99-104
25157454-0	2014	Apelin counteracts vasopressin-induced water reabsorption via cross talk between apelin and vasopressin receptor signaling pathways in the rat collecting duct.	Water	39-44	arginine vasopressin	Rattus norvegicus	19-30
25111015-3	2014	We have recently found that FlaOHs inhibit catalase, the heme enzyme which catalyzes the decomposition of hydrogen peroxide (H2O2) into water and molecular oxygen.	Water	136-141	catalase	Homo sapiens	43-51
25103169-0	2014	ESBL-producing Enterobacteriaceae in environmental water in Dhaka, Bangladesh.	Water	51-56	EsbL	Escherichia coli	0-4
25248629-3	2014	Hypotonic hyponatremia has multiple etiologies, but only two general mechanisms of development, defective water excretion, usually because of elevated serum vasopressin levels, or excessive fluid intake.	Water	106-111	arginine vasopressin	Homo sapiens	157-168
25103169-2	2014	We examined surface water in Dhaka, capital of Bangladesh and isolated ESBL-producing Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae, suggesting the potential role of water for the dissemination and transmission of resistant genes among microorganisms.	Water	20-25	EsbL	Escherichia coli	71-75
25103169-2	2014	We examined surface water in Dhaka, capital of Bangladesh and isolated ESBL-producing Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae, suggesting the potential role of water for the dissemination and transmission of resistant genes among microorganisms.	Water	185-190	EsbL	Escherichia coli	71-75
25348467-7	2014	For instance, at the water content of 1.77%, insulin without any protectants yields the highest RMSD value as 0.451 nm, then the RMSD of insulin in presence of trehalose only ca.	Water	21-26	insulin	Homo sapiens	45-52
25459767-0	2014	DFT study on X- (H2O)(n=1-10) (X=OH, NO2, NO3, CO3) anionic water cluster.	Water	17-20	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
25459767-0	2014	DFT study on X- (H2O)(n=1-10) (X=OH, NO2, NO3, CO3) anionic water cluster.	Water	60-65	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
25459767-1	2014	A theoretical study to understand the interaction between anion and the water molecules through the hydration (X(-) (H2O)n (X=OH, NO2, NO3, CO3), where n=1-10), using the density functional theory method with B3LYP functional and 6-311++G(d,p) basis set has been carried out systematically.	Water	72-77	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
25459767-1	2014	A theoretical study to understand the interaction between anion and the water molecules through the hydration (X(-) (H2O)n (X=OH, NO2, NO3, CO3), where n=1-10), using the density functional theory method with B3LYP functional and 6-311++G(d,p) basis set has been carried out systematically.	Water	117-120	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
25096900-0	2014	In vitro effect of H2O 2, some transition metals and hydroxyl radical produced via fenton and fenton-like reactions, on the catalytic activity of AChE and the hydrolysis of ACh.	Water	19-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-150
25277273-8	2014	According to the solubility values in water and simulated gastric fluid, FMT-MLT exhibits such a performance that improves on the solubility of the commercially available polymorph.	Water	38-43	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	77-80
25008241-2	2014	Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins that allow the movement of water, but also of small solutes, such as glycerol, across cell membranes.	Water	110-115	aquaporin 9	Homo sapiens	31-35
25266632-5	2014	Our results show that the constitutively silenced PIP1 (35S promoter) plants had decreased PIP1 transcript and protein levels and decreased mesophyll and BS osmotic water permeability (P(f)), mesophyll conductance of CO2, photosynthesis, K(leaf), transpiration, and shoot biomass.	Water	165-170	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	50-54
25184890-3	2014	Application of chemically standardized jujube water extract stimulated erythropoietin expression in a dose-dependent manner, with the highest response by ~ 100 % of increase.	Water	46-51	erythropoietin	Homo sapiens	71-85
24759153-3	2014	In clinical practice, inadvertent rapid correction frequently occurs due to water diuresis, when vasopressin action suddenly ceases.	Water	76-81	arginine vasopressin	Rattus norvegicus	97-108
25248683-0	2014	Enhanced water-soluble derivative of PC407 as a novel potential COX-2 inhibitor injectable formulation.	Water	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
25264579-4	2014	Cross-linking the PTBAEMA latex particles adsorbed at the n-dodecane/water interface using this oil-soluble PPG-TDI cross-linker at around 0 (o)C led to robust colloidosomes that survived an acid challenge.	Water	69-74	serglycin	Homo sapiens	108-111
25061917-6	2014	The three-dimensional structure of hemoglobin complexed with TD-1 revealed that monomeric units of TD-1 bound covalently to beta-Cys93 and beta-Cys112, as well as noncovalently to the central water cavity of the hemoglobin tetramer.	Water	192-197	TLX1 neighbor	Homo sapiens	61-65
25061917-6	2014	The three-dimensional structure of hemoglobin complexed with TD-1 revealed that monomeric units of TD-1 bound covalently to beta-Cys93 and beta-Cys112, as well as noncovalently to the central water cavity of the hemoglobin tetramer.	Water	192-197	TLX1 neighbor	Homo sapiens	99-103
25129155-5	2014	The total PAH concentration in fog-water ranged from non-detected to 216 ng L(-1) (mean of 45 ng L(-1)), and was much higher in fall than in winter.	Water	35-40	zinc finger protein, FOG family member 1	Homo sapiens	31-34
25160910-4	2014	Excellent activities of superoxide dismutation by PEI-SOD@HSN are found and transformation of H2 O2 to water by PEI-CAT@HSN.	Water	103-108	catalase	Homo sapiens	116-119
25160910-5	2014	When PEI-SOD and PEI-CAT are co-encapsulated, cascade transformation of superoxide through hydrogen peroxide to water was facile.	Water	112-117	catalase	Homo sapiens	21-24
25064486-6	2014	Firstly, unlike the 185 nm and 253.7 nm cases, water photolysis by the 172 nm wavelength revealed a depth of photoactive water layer an order of magnitude greater (~230-390 mum, depending on the specific operating conditions) than the 1-log photon penetration layer (~18 mum).	Water	47-52	latexin	Homo sapiens	173-176
25064486-6	2014	Firstly, unlike the 185 nm and 253.7 nm cases, water photolysis by the 172 nm wavelength revealed a depth of photoactive water layer an order of magnitude greater (~230-390 mum, depending on the specific operating conditions) than the 1-log photon penetration layer (~18 mum).	Water	47-52	latexin	Homo sapiens	271-274
25064486-6	2014	Firstly, unlike the 185 nm and 253.7 nm cases, water photolysis by the 172 nm wavelength revealed a depth of photoactive water layer an order of magnitude greater (~230-390 mum, depending on the specific operating conditions) than the 1-log photon penetration layer (~18 mum).	Water	121-126	latexin	Homo sapiens	173-176
25222124-1	2014	We show that the hybrids of single-layer graphene oxide with manganese ferrite magnetic nanoparticles have the best adsorption properties for efficient removal of Pb(II), As(III), and As(V) from contaminated water.	Water	208-213	submaxillary gland androgen regulated protein 3B	Homo sapiens	163-169
25248683-4	2014	This derivative represents the profiles of prodrug and potential candidate of PC407 for the development of injectable COX-2 inhibitor due to extraordinary water solubility, low toxicity, and impressive analgesic activity.	Water	155-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
25328496-5	2014	The water dipole in the protein environment is found to be much different from that in the bulk and in such models as SPC or TIPnP.	Water	4-9	proline rich protein gene cluster	Homo sapiens	118-121
25236171-4	2014	It is the first time that this group of halopyrroles were identified as wastewater DBPs (though 2,3,5-tribromopyrrole has been found to be a DBP in drinking water before).	Water	77-82	D-box binding PAR bZIP transcription factor	Homo sapiens	83-86
25271384-1	2014	Nitrate (NO3(-)) is an abundant component of aerosols, boundary layer surface films, and surface water.	Water	97-102	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
25172614-4	2014	The results, mainly, showed the sorption of PFASs onto pellet surface from surrounding water with concentrations from method limit of quantification to 115 ng/kg for C5, C7, C8 and C10 carboxylic acids and C8 sulfonate acid.	Water	87-92	homeobox C10	Homo sapiens	181-184
25156670-1	2014	Lysozyme can be electrochemically detected after adsorption at an electrified gel-water interface.	Water	82-87	lysozyme	Homo sapiens	0-8
25308934-16	2014	However, water extract exhibited higher efficacy in ameliorating ROS build up, early apoptotic membrane phosphatidylserine externalization as well as inhibition of caspase-3 cleavage.	Water	9-14	caspase 3	Homo sapiens	164-173
25196121-0	2014	Charge polarization at a Au-TiC interface and the generation of highly active and selective catalysts for the low-temperature water-gas shift reaction.	Water	126-131	pleckstrin and Sec7 domain containing 4	Homo sapiens	28-31
25196121-2	2014	Strong metal-support interactions make Au/TiC(001) an excellent catalyst for the low-temperature water-gas shift (WGS), with turnover frequencies orders of magnitude larger than those observed for conventional metal/oxide catalysts.	Water	97-102	pleckstrin and Sec7 domain containing 4	Homo sapiens	42-45
25208126-1	2014	The diffuse biomat formed on the bottom of shallow, open-water unit process wetland cells contains suboxic zones that provide conditions conducive to NO3(-) removal via microbial denitrification, as well as anaerobic ammonium oxidation (anammox).	Water	57-62	NBL1, DAN family BMP antagonist	Homo sapiens	150-153
25062659-2	2014	We performed solid-state fermentation by using Bacillus subtilis strain N-2 to produce a water-soluble fertilizer containing amino acids.	Water	89-94	leghemoglobin A	Glycine max	72-75
25051344-1	2014	In Alzheimer"s disease (AD), native Abeta protein monomers aggregate through the formation of a variety of water-soluble, toxic oligomers, ultimately leading to insoluble fibrillar deposits.	Water	107-112	amyloid beta precursor protein	Homo sapiens	36-41
25632375-2	2014	The quantitative recommendation to "drink enough water to dilute urine" might further facilitate weight loss by increasing fat oxidation via cell hydration-mediated changes in insulin.	Water	49-54	insulin	Homo sapiens	176-183
25144541-1	2014	An infrared attenuated total reflection (IR-ATR) method for detecting, differentiating, and quantifying hydrocarbons dissolved in water relevant for oil spills by evaluating the "fingerprint" of the volatile organic compounds (VOCs) associated with individual oil types in the mid-infrared spectral range (i.e., 800-600 cm(-1)) is presented.	Water	130-135	ATR serine/threonine kinase	Homo sapiens	44-47
25208126-7	2014	The annual temperature-corrected areal first-order NO3(-) removal rate (k20 = 59.4 +- 6.2 m yr(-1)) was higher than values reported for more than 75% of vegetated wetlands that treated water in which NO3(-) was the primary nitrogen species (e.g., nitrified secondary wastewater effluent and agricultural runoff).	Water	185-190	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
25208126-8	2014	The inclusion of open-water cells, originally designed for the removal of trace organic contaminants and pathogens, in unit-process wetlands may enhance NO3(-) removal as compared to existing vegetated wetland systems.	Water	22-27	NBL1, DAN family BMP antagonist	Homo sapiens	153-156
25108041-1	2014	Angiotensin II (Ang II) stimulates water and saline intakes when injected into the brain of rats.	Water	35-40	angiotensinogen	Rattus norvegicus	0-14
25112872-1	2014	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and urine concentration.	Water	48-53	arginine vasopressin	Homo sapiens	26-37
25112872-1	2014	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and urine concentration.	Water	82-87	arginine vasopressin	Homo sapiens	26-37
24984238-6	2014	Moreover, hydrogen bond analyses show the water-mediated hydrogen-bond network near the S1 pocket between uPA, and the ligand probably leads to excellent selectivity of these inhibitors on uPA.	Water	42-47	plasminogen activator, urokinase	Homo sapiens	106-109
24984238-6	2014	Moreover, hydrogen bond analyses show the water-mediated hydrogen-bond network near the S1 pocket between uPA, and the ligand probably leads to excellent selectivity of these inhibitors on uPA.	Water	42-47	plasminogen activator, urokinase	Homo sapiens	189-192
25229686-3	2014	AQP0 functions as a water channel and as a cell-to-cell adhesion (CTCA) molecule in the lens.	Water	20-25	major intrinsic protein of lens fiber	Mus musculus	0-4
25229686-13	2014	In summary, lens transparency, CTCA and compact packing of fiber cells were affected due to the loss of 50% AQP0 leading to larger extracellular space, more water content and SA, possibly due to alteration in RING.	Water	157-162	major intrinsic protein of lens fiber	Mus musculus	108-112
25108041-1	2014	Angiotensin II (Ang II) stimulates water and saline intakes when injected into the brain of rats.	Water	35-40	angiotensinogen	Rattus norvegicus	16-22
25108041-3	2014	Acute repeated injections, however, decrease the water intake response to Ang II without affecting saline intake.	Water	49-54	angiotensinogen	Rattus norvegicus	74-80
25108041-4	2014	Previous studies provide evidence that Ang II-induced water intake is mediated via the classical G protein coupling pathway, whereas the saline intake caused by Ang II is mediated by an ERK 1/2 MAP kinase signaling pathway.	Water	54-59	angiotensinogen	Rattus norvegicus	39-45
25379492-6	2014	RESULTS: SBP, DBP, mean BP (mBP), and RPP decreased significantly after water immersion, but HR was unchanged.	Water	72-77	D-box binding PAR bZIP transcription factor	Homo sapiens	14-17
24965789-7	2014	A typical example is atrial natriuretic peptide (ANP); ANP is secreted in response to increased blood volume and acts on various osmoregulatory organs to restore volume in rainbow trout as it does in mammals, but it is secreted in response to increased plasma osmolality, and specifically decreases NaCl, and not water, in the body of eels.	Water	313-318	atrial natriuretic peptide	Oncorhynchus mykiss	21-47
25031229-1	2014	Intracerebroventricular injection of stable somatostatin (SST) agonists stimulates food and water intake in rats.	Water	92-97	somatostatin	Rattus norvegicus	44-56
25031229-5	2014	By contrast, the stable pan-somatostatin agonist ODT8-SST (1 mug/rat icv) increased both water and food intake by 4.9- and 3.7-fold, respectively.	Water	89-94	somatostatin	Rattus norvegicus	28-40
25031229-8	2014	Losartan (100 mug/rat icv), an angiotensin receptor 1 (AT1) antagonist, completely blocked the water consumption induced by intracerebroventricular ODT8-SST, whereas intracerebroventricular injection of S-406-028 did not modify the intracerebroventricular ANG II-induced dipsogenic response.	Water	95-100	angiotensin II receptor, type 1b	Rattus norvegicus	55-58
25341413-0	2014	Rain water transport and storage in a model sandy soil with hydrogel particle additives.	Water	5-10	Ras interacting protein 1	Homo sapiens	0-4
25172149-3	2014	Based on crystal structures of GluK1 in complex with related ligands, the compounds were designed to explore possible interactions with non-conserved residues outside the glutamate ligand binding site and challenge the water binding network.	Water	219-224	glutamate ionotropic receptor kainate type subunit 1	Homo sapiens	31-36
25065793-5	2014	C2 was a latent parameter determined by CART to differentiate water samples of oxic and secondary sedimentation tanks from the successive treatment units, indirectly proving that most of tyrosine-like material was degraded by anaerobic microorganisms.	Water	62-67	CART prepropeptide	Homo sapiens	40-44
25037005-5	2014	Finally, partial insertion of Abeta monomer does not enhance water permeation through the DMPC bilayer and even causes considerable dehydration of the lipid-water interface.	Water	157-162	amyloid beta precursor protein	Homo sapiens	30-35
25341413-1	2014	We study rain water infiltration and drainage in a dry model sandy soil with superabsorbent hydrogel particle additives by measuring the mass of retained water for non-ponding rainfall using a self-built 3D laboratory set-up.	Water	14-19	Ras interacting protein 1	Homo sapiens	9-13
25693383-0	2014	[Sorption characteristics of tea waste modified by hydrated ferric oxide toward Pb(II) in water].	Water	90-95	submaxillary gland androgen regulated protein 3B	Homo sapiens	80-86
25145394-6	2014	The high sensitivity of this method was demonstrated by detection of human serum albumin and human cytochrome b5 in 10(-17) -10(-18) m water solutions.	Water	135-140	albumin	Homo sapiens	81-88
23979320-0	2014	The influence of drinking-water pollution with heavy metal on the expression of IL-4 and IFN-gamma in mice by real-time polymerase chain reaction.	Water	26-31	interferon gamma	Mus musculus	89-98
25017970-4	2014	in the priming phase, but not in the effector phase, of immune response of EAU enhanced disease scores and its related immune responses including DTH, Ag-specific T cell proliferation and the production of IL-17 and IFN-gamma.	Water	75-78	interferon gamma	Mus musculus	216-225
25197764-0	2014	Mulberry water extracts inhibit atherosclerosis through suppression of the integrin-beta3/focal adhesion kinase complex and downregulation of nuclear factor kappaB signaling in vivo and in vitro.	Water	9-14	integrin beta-3	Oryctolagus cuniculus	75-89
25270511-2	2014	The probe was obtained via the aggregation of a modified substance P in a terpyridine-Fe (II) complex with Gd (III)-DOTA into well-defined nanostructures, which effectively weaken ligand fluorescence and slow the exchange rate of inner-sphere water molecules.	Water	243-248	tachykinin precursor 1	Homo sapiens	57-68
25371524-6	2014	S.c. administration of PTH normalized urine and sodium excretion in cirrhotic rats and also increased renal plasma flow, PGE2 urinary excretion, and free-water clearance.	Water	154-159	parathyroid hormone	Rattus norvegicus	23-26
25587330-1	2014	A water soluble polysaccharide, HB-1, with a molecular weight of 23,930, was isolated from radix Ranunculi ternati.	Water	2-7	histocompatibility minor HB-1	Homo sapiens	32-36
25095973-4	2014	Renal collecting duct water absorption is mainly mediated by the water channel aquaporin 1 and 2 (AQP1 and AQP2).	Water	22-27	aquaporin-1	Capra hircus	98-102
25095973-4	2014	Renal collecting duct water absorption is mainly mediated by the water channel aquaporin 1 and 2 (AQP1 and AQP2).	Water	65-70	aquaporin-1	Capra hircus	98-102
25063824-2	2014	This response is beneficial because this type of activity potentiates vasopressin secretion from axon terminals in the neurohypophysis and thus promotes homoeostatic water reabsorption from the kidney.	Water	166-171	arginine vasopressin	Rattus norvegicus	70-81
25277886-4	2014	For 12 weeks, the subjects consumed 65 g WPC or 60 g SPI that was dissolved in 500 mL water 30 minutes before their ad libitum lunch.	Water	86-91	chromogranin A	Homo sapiens	53-56
25422551-14	2014	RESULTS: The water-extraction of Astragali Radix and Lycopi Herba significantly lowered fasting glucose and urine albumin in diabetic rats through inhibition of TGF-beta1 mRNA and protein expression in the STZ-induced diabetic rats, and regulation of the Smad3, Smad7, Smurf1, Smurf2 mRNA and protein expression, as well as elevated 26S proteasome activity to play control effect in DN.	Water	13-18	transforming growth factor, beta 1	Rattus norvegicus	161-170
25422551-14	2014	RESULTS: The water-extraction of Astragali Radix and Lycopi Herba significantly lowered fasting glucose and urine albumin in diabetic rats through inhibition of TGF-beta1 mRNA and protein expression in the STZ-induced diabetic rats, and regulation of the Smad3, Smad7, Smurf1, Smurf2 mRNA and protein expression, as well as elevated 26S proteasome activity to play control effect in DN.	Water	13-18	SMAD family member 3	Rattus norvegicus	255-260
25422551-14	2014	RESULTS: The water-extraction of Astragali Radix and Lycopi Herba significantly lowered fasting glucose and urine albumin in diabetic rats through inhibition of TGF-beta1 mRNA and protein expression in the STZ-induced diabetic rats, and regulation of the Smad3, Smad7, Smurf1, Smurf2 mRNA and protein expression, as well as elevated 26S proteasome activity to play control effect in DN.	Water	13-18	SMAD family member 7	Rattus norvegicus	262-267
25422551-14	2014	RESULTS: The water-extraction of Astragali Radix and Lycopi Herba significantly lowered fasting glucose and urine albumin in diabetic rats through inhibition of TGF-beta1 mRNA and protein expression in the STZ-induced diabetic rats, and regulation of the Smad3, Smad7, Smurf1, Smurf2 mRNA and protein expression, as well as elevated 26S proteasome activity to play control effect in DN.	Water	13-18	SMAD specific E3 ubiquitin protein ligase 2	Rattus norvegicus	277-283
25138219-6	2014	In vivo, adult C57BL/6J male mice were fed a folate-free diet for 4 weeks to induce hHcys, and TXNIP was inhibited by verapamil (1 mg/ml in drinking water) or by local microbubble-ultrasound TXNIP shRNA transfection.	Water	149-154	thioredoxin interacting protein	Mus musculus	95-100
25110916-2	2014	The yield of the corresponding Hiyama coupling products is high up to around 90% in water and isopropanol under an ambient atmosphere in the presence of KOH and NaF.	Water	84-89	C-X-C motif chemokine ligand 8	Homo sapiens	161-164
24969505-0	2014	Linear and nonlinear microrheology of lysozyme layers forming at the air-water interface.	Water	73-78	lysozyme	Homo sapiens	38-46
24969505-1	2014	We report experiments studying the mechanical evolution of layers of the protein lysozyme adsorbing at the air-water interface using passive and active microrheology techniques to investigate the linear and nonlinear rheological response, respectively.	Water	111-116	lysozyme	Homo sapiens	81-89
25115848-0	2014	Bright, highly water-soluble triazacyclononane europium complexes to detect ligand binding with time-resolved FRET microscopy.	Water	15-20	AT-rich interaction domain 3A	Homo sapiens	0-6
25240371-2	2014	In general, the reversible work required to bring two nanotubes from a dissociated state (free energy reference) to contact state (free energy minimum) is more favorable and less temperature-dependent in TIP4P-FQ than in SPC/E water models.	Water	227-232	proline rich protein gene cluster	Homo sapiens	221-224
25484680-1	2014	In the title complex, [Co(C15H6ClO4)2(H2O)4] 2H2O, the Co(II) ion is bound by two carboxylate O atoms of two 5-chloro-9,10-anthra-quinone-1-carboxyl-ate anions and four water O atoms in a trans conformation, forming an irregular octa-hedral coordination geometry.	Water	169-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
25240371-5	2014	Further investigation of hydrogen bonding network in intertube water reveals that TIP4P-FQ retains fewer hydrogen bonds than SPC/E, which correlates with the lower water number density in this region.	Water	63-68	proline rich protein gene cluster	Homo sapiens	125-128
25079380-4	2014	The cleaning properties of water-nonionic surfactant-2-butanone (MEK) were assessed both on model surfaces and on a XIII century fresco that could not be cleaned using conventional methods.	Water	27-32	mitogen-activated protein kinase kinase 7	Homo sapiens	65-68
25081572-2	2014	Picomolar level detection of TNT was possible in water by the CBF nanoparticles and nanogram level TNT sensing in the vapour phase could be achieved with the CBF supramolecular rods.	Water	49-54	chromosome 16 open reading frame 82	Homo sapiens	29-32
25240371-5	2014	Further investigation of hydrogen bonding network in intertube water reveals that TIP4P-FQ retains fewer hydrogen bonds than SPC/E, which correlates with the lower water number density in this region.	Water	164-169	proline rich protein gene cluster	Homo sapiens	125-128
25166739-0	2014	Functional water molecules in rhodopsin activation.	Water	11-16	rhodopsin	Homo sapiens	30-39
25166739-2	2014	Studies of rhodopsin, a prototype GPCR, have suggested that water plays an important role in mediating the activation of family A GPCRs.	Water	60-65	rhodopsin	Homo sapiens	11-20
25166739-4	2014	Using all-atom molecular dynamics simulations in combination with inhomogeneous fluid theory, we identify in this work the positioning of functional water molecules in the inactive state, the Meta II state, and the constitutive active state of rhodopsin, basing on the thermodynamic signatures of the water molecules.	Water	149-154	rhodopsin	Homo sapiens	244-253
24840541-1	2014	[2.2.2]Paracylcophane (tricyclophane, TCP) is a macrocycle with three phenyl substituents linked by ethyl bridges (-CH2CH2-) in the para-position, forming an aromatic-rich pocket capable of binding various substituents, including nature"s solvent, water.	Water	248-253	serine peptidase inhibitor Kazal type 1	Homo sapiens	38-41
25166739-4	2014	Using all-atom molecular dynamics simulations in combination with inhomogeneous fluid theory, we identify in this work the positioning of functional water molecules in the inactive state, the Meta II state, and the constitutive active state of rhodopsin, basing on the thermodynamic signatures of the water molecules.	Water	301-306	rhodopsin	Homo sapiens	244-253
24840541-5	2014	2013, 138, 064308] that reported on the ground state conformational preferences of TCP, the focus of the present study is on the infrared and ultraviolet spectroscopy of TCP-(H2O)n clusters with n = 1-5.	Water	175-178	serine peptidase inhibitor Kazal type 1	Homo sapiens	83-86
24840541-14	2014	The TCP-(H2O)n, n = 3-5 clusters all form H-bonded cycles, retaining their preferred structures in the absence of TCP, but distorted significantly by the presence of the TCP molecule.	Water	9-12	serine peptidase inhibitor Kazal type 1	Homo sapiens	4-7
24840541-14	2014	The TCP-(H2O)n, n = 3-5 clusters all form H-bonded cycles, retaining their preferred structures in the absence of TCP, but distorted significantly by the presence of the TCP molecule.	Water	9-12	serine peptidase inhibitor Kazal type 1	Homo sapiens	114-117
24840541-5	2014	2013, 138, 064308] that reported on the ground state conformational preferences of TCP, the focus of the present study is on the infrared and ultraviolet spectroscopy of TCP-(H2O)n clusters with n = 1-5.	Water	175-178	serine peptidase inhibitor Kazal type 1	Homo sapiens	170-173
25166739-7	2014	We thereby propose a hypothesis of the water-mediated rhodopsin activation pathway.	Water	39-44	rhodopsin	Homo sapiens	54-63
24840541-6	2014	Resonant two-photon ionization (R2PI) was used to interrogate the mass selected electronic spectrum of the clusters, reporting on the perturbations imposed on the electronic states of TCP as the size of the water clusters bound to it vary in size from n = 1-5.	Water	207-212	serine peptidase inhibitor Kazal type 1	Homo sapiens	184-187
24840541-14	2014	The TCP-(H2O)n, n = 3-5 clusters all form H-bonded cycles, retaining their preferred structures in the absence of TCP, but distorted significantly by the presence of the TCP molecule.	Water	9-12	serine peptidase inhibitor Kazal type 1	Homo sapiens	114-117
24840541-15	2014	TCP-(H2O)3 divides its population between two conformational isomers that differ in the direction of the H-bonds in the cycle, either clockwise or counterclockwise, which are distinguishable by virtue of the C2 symmetry of the TCP monomer.	Water	5-8	serine peptidase inhibitor Kazal type 1	Homo sapiens	0-3
24840541-7	2014	The TCP-(H2O)n S0-S1 origins are shifted to lower frequency from the monomer, indicating an increased binding energy of the water or water network in the excited state.	Water	9-12	serine peptidase inhibitor Kazal type 1	Homo sapiens	4-7
24840541-15	2014	TCP-(H2O)3 divides its population between two conformational isomers that differ in the direction of the H-bonds in the cycle, either clockwise or counterclockwise, which are distinguishable by virtue of the C2 symmetry of the TCP monomer.	Water	5-8	serine peptidase inhibitor Kazal type 1	Homo sapiens	227-230
24840541-7	2014	The TCP-(H2O)n S0-S1 origins are shifted to lower frequency from the monomer, indicating an increased binding energy of the water or water network in the excited state.	Water	124-129	serine peptidase inhibitor Kazal type 1	Homo sapiens	4-7
25121958-0	2014	Transition-state structure for the quintessential SN2 reaction of a carbohydrate: reaction of alpha-glucopyranosyl fluoride with azide ion in water.	Water	142-147	solute carrier family 38 member 5	Homo sapiens	50-53
24840541-7	2014	The TCP-(H2O)n S0-S1 origins are shifted to lower frequency from the monomer, indicating an increased binding energy of the water or water network in the excited state.	Water	133-138	serine peptidase inhibitor Kazal type 1	Homo sapiens	4-7
24840541-8	2014	Ground state resonant ion-dip infrared (RIDIR) spectra of TCP-(H2O)n (n = 1-5) clusters were recorded in the OH stretch region, which probes the H-bonded water networks present and the perturbations imposed on them by TCP.	Water	63-66	serine peptidase inhibitor Kazal type 1	Homo sapiens	58-61
24840541-8	2014	Ground state resonant ion-dip infrared (RIDIR) spectra of TCP-(H2O)n (n = 1-5) clusters were recorded in the OH stretch region, which probes the H-bonded water networks present and the perturbations imposed on them by TCP.	Water	154-159	serine peptidase inhibitor Kazal type 1	Homo sapiens	58-61
24840541-10	2014	The H2O molecule in TCP-(H2O)1 sits on top of the binding pocket, donating both of its hydrogen atoms to the aromatic-rich interior of the monomer.	Water	4-7	serine peptidase inhibitor Kazal type 1	Homo sapiens	20-23
24840541-12	2014	TCP-(H2O)2 also exists in a single conformational isomer that retains the same double-donor binding motif for the first water molecule, with the second H2O acting as a donor to the first, thereby forming a water dimer.	Water	5-8	serine peptidase inhibitor Kazal type 1	Homo sapiens	0-3
24840541-12	2014	TCP-(H2O)2 also exists in a single conformational isomer that retains the same double-donor binding motif for the first water molecule, with the second H2O acting as a donor to the first, thereby forming a water dimer.	Water	120-125	serine peptidase inhibitor Kazal type 1	Homo sapiens	0-3
24840541-12	2014	TCP-(H2O)2 also exists in a single conformational isomer that retains the same double-donor binding motif for the first water molecule, with the second H2O acting as a donor to the first, thereby forming a water dimer.	Water	152-155	serine peptidase inhibitor Kazal type 1	Homo sapiens	0-3
24840541-12	2014	TCP-(H2O)2 also exists in a single conformational isomer that retains the same double-donor binding motif for the first water molecule, with the second H2O acting as a donor to the first, thereby forming a water dimer.	Water	206-211	serine peptidase inhibitor Kazal type 1	Homo sapiens	0-3
24990857-2	2014	Similar inhibition was observed after bumetanide, and the effect of bumetanide was abolished by GN or vice versa, suggesting that both act on the same target, Na(+)-K(+)-2Cl(-) cotransporter (NKCC), which is a key player for the Na(+)-K(+)-Cl(-) transport system responsible for water absorption in marine teleost intestine.	Water	279-284	solute carrier family 12 member 1	Homo sapiens	159-190
24990857-6	2014	Quantitative PCR analysis revealed the presence of major proteins involved in water absorption; the NKCC2beta and AQP1 genes whose expression was markedly upregulated after seawater acclimation.	Water	78-83	aquaporin 1 (Colton blood group)	Homo sapiens	114-118
25122155-0	2014	Water-soluble and cleavable quercetin-amino acid conjugates as safe modulators for P-glycoprotein-based multidrug resistance.	Water	0-5	ATP binding cassette subfamily B member 1	Homo sapiens	83-97
25151856-1	2014	A new strategy has been designed for visualized detection of the conformation changes of calmodulin bound to target peptide (CaM-M13) based on the conformation sensitive property of a water-soluble conjugated polythiophene derivative (PMNT) and the electrostatic interactions of PMNT/CaM-M13.	Water	184-189	calmodulin 1	Homo sapiens	89-99
25151856-1	2014	A new strategy has been designed for visualized detection of the conformation changes of calmodulin bound to target peptide (CaM-M13) based on the conformation sensitive property of a water-soluble conjugated polythiophene derivative (PMNT) and the electrostatic interactions of PMNT/CaM-M13.	Water	184-189	calmodulin 1	Homo sapiens	125-128
25146699-4	2014	We also show that, in cultured primary astrocytes: (i) both CRFR1 and AQP4 are expressed; (ii) exogenous CRF, acting through CRFR1, triggers signaling of cAMP/PKA, intracellular Ca(2+), and PKCepsilon; and (iii) the up-regulated cAMP/PKA signaling contributes to the phosphorylation and expression of AQP4 to enhance water influx into astrocytes and produces an up-regulation of ET-1 expression.	Water	317-322	cathelicidin antimicrobial peptide	Rattus norvegicus	154-158
25141292-0	2014	Chemoselective Wittig and Michael ligations of unprotected peptidyl phosphoranes in water furnish potent inhibitors of caspase-3.	Water	84-89	caspase 3	Homo sapiens	119-128
24840541-16	2014	TCP-(H2O)4 and TCP-(H2O)5 have OH stretch IR spectra that are close analogues of their benzene-(H2O)n counterparts in the H-bonded OH stretch region, but differ somewhat in the free and pi OH stretch regions as the tetramer and pentamer cycles begin to spill out of the pocket interior.	Water	5-8	serine peptidase inhibitor Kazal type 1	Homo sapiens	0-3
24840541-16	2014	TCP-(H2O)4 and TCP-(H2O)5 have OH stretch IR spectra that are close analogues of their benzene-(H2O)n counterparts in the H-bonded OH stretch region, but differ somewhat in the free and pi OH stretch regions as the tetramer and pentamer cycles begin to spill out of the pocket interior.	Water	5-8	serine peptidase inhibitor Kazal type 1	Homo sapiens	15-18
24840541-16	2014	TCP-(H2O)4 and TCP-(H2O)5 have OH stretch IR spectra that are close analogues of their benzene-(H2O)n counterparts in the H-bonded OH stretch region, but differ somewhat in the free and pi OH stretch regions as the tetramer and pentamer cycles begin to spill out of the pocket interior.	Water	20-23	serine peptidase inhibitor Kazal type 1	Homo sapiens	0-3
24840541-16	2014	TCP-(H2O)4 and TCP-(H2O)5 have OH stretch IR spectra that are close analogues of their benzene-(H2O)n counterparts in the H-bonded OH stretch region, but differ somewhat in the free and pi OH stretch regions as the tetramer and pentamer cycles begin to spill out of the pocket interior.	Water	20-23	serine peptidase inhibitor Kazal type 1	Homo sapiens	15-18
24840541-16	2014	TCP-(H2O)4 and TCP-(H2O)5 have OH stretch IR spectra that are close analogues of their benzene-(H2O)n counterparts in the H-bonded OH stretch region, but differ somewhat in the free and pi OH stretch regions as the tetramer and pentamer cycles begin to spill out of the pocket interior.	Water	20-23	serine peptidase inhibitor Kazal type 1	Homo sapiens	0-3
24840541-16	2014	TCP-(H2O)4 and TCP-(H2O)5 have OH stretch IR spectra that are close analogues of their benzene-(H2O)n counterparts in the H-bonded OH stretch region, but differ somewhat in the free and pi OH stretch regions as the tetramer and pentamer cycles begin to spill out of the pocket interior.	Water	20-23	serine peptidase inhibitor Kazal type 1	Homo sapiens	15-18
25148136-4	2014	This peptide-bound-like state of CaM-4Ca(2+) is entropically stabilized (DeltaS = 280 +- 35 J mol(-1) K(-1)) relative to the native state, water-depleted, and likely parental to specific bound states.	Water	139-144	calmodulin 1	Homo sapiens	33-36
25148521-1	2014	Nitrate (NO3-) is a widespread contaminant of groundwater and surface water across the United States that has deleterious effects to human and ecological health.	Water	52-57	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
25207608-8	2014	MOR and DOR also link to inhibition of submucosal secretomotor neurons, reducing active Cl(-) secretion and passive water movement into the colonic lumen.	Water	116-121	tumor protein p53 inducible nuclear protein 2	Homo sapiens	8-11
25010156-0	2014	Speciation analysis of inorganic arsenic in river water by Amberlite IRA 910 resin immobilized in a polyacrylamide gel as a selective binding agent for As(V) in diffusive gradient thin film technique.	Water	50-55	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	152-157
24666321-0	2014	Infrared photodissociation spectroscopy of microhydrated nitrate-nitric acid clusters NO3(-)(HNO3)(m)(H2O)(n).	Water	102-105	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
24666321-1	2014	Infrared multiple photon dissociation (IRMPD) spectra of NO3(-)(HNO3)m(H2O)n(H2)z with m = 1-3, up to n = 8 and z &gt;= 1, are measured in the fingerprint region (550-1880 cm(-1)), directly probing the NO-stretching modes, as well as bending and other lower frequency modes.	Water	71-74	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
24666321-5	2014	Addition of at least one more nitric acid molecule or two more water molecules weakens the hydrogen bond network, breaking the symmetry of this arrangement and leading to localization of the proton near one of the nitrate cores, effectively forming HNO3 hydrogen-bonded to NO3(-).	Water	63-68	NBL1, DAN family BMP antagonist	Homo sapiens	250-253
25111077-7	2014	Catalytic applications of (oCB-L1)Pd and (mCB-L1)Pd have shown the complexes are good catalyst precursors in Suzuki coupling in water and with very low amounts of catalyst loadings.	Water	128-133	Casitas B-lineage lymphoma, pseudogene 1	Mus musculus	42-48
24920735-5	2014	Vasopressin contributes to venous congestion through aquaporin-mediated water retention.	Water	72-77	arginine vasopressin	Homo sapiens	0-11
24920735-6	2014	Additional water retention may be mediated through vasopressin-induced medullary urea transport and hyaluronan but needs further study.	Water	11-16	arginine vasopressin	Homo sapiens	51-62
24821012-1	2014	BACKGROUND: Investigate the impact of natural N- or C-terminal post-translational truncations of lens mature fiber cell Aquaporin 0 (AQP0) on water permeability (Pw) and cell-to-cell adhesion (CTCA) functions.	Water	142-147	major intrinsic protein of lens fiber	Mus musculus	120-131
24821012-1	2014	BACKGROUND: Investigate the impact of natural N- or C-terminal post-translational truncations of lens mature fiber cell Aquaporin 0 (AQP0) on water permeability (Pw) and cell-to-cell adhesion (CTCA) functions.	Water	142-147	major intrinsic protein of lens fiber	Mus musculus	133-137
25099180-2	2014	The condition primarily results from the combination of impaired free water excretion due to elevated vasopressin levels in conjunction with a source of free water intake.	Water	70-75	arginine vasopressin	Homo sapiens	102-113
25054009-5	2014	The results showed that the intraperitoneal injection of ozonated water decreased the levels of tumor necrosis factor-alpha (TNF-alpha) and increased the activity of superoxide dismutase (SOD).	Water	66-71	tumor necrosis factor	Mus musculus	96-123
25054009-5	2014	The results showed that the intraperitoneal injection of ozonated water decreased the levels of tumor necrosis factor-alpha (TNF-alpha) and increased the activity of superoxide dismutase (SOD).	Water	66-71	tumor necrosis factor	Mus musculus	125-134
24571080-1	2014	Aquaporin-4 (AQP4) and glutamate transporter-1 (GLT-1) represent the major water and glutamate astrocyte buffering gateways in the brain.	Water	75-80	solute carrier family 1 member 2	Homo sapiens	23-46
24571080-1	2014	Aquaporin-4 (AQP4) and glutamate transporter-1 (GLT-1) represent the major water and glutamate astrocyte buffering gateways in the brain.	Water	75-80	solute carrier family 1 member 2	Homo sapiens	48-53
24571080-4	2014	AQP4/GLT-1 colocalization showed higher coefficients for the perilesional cortices compared with controls, suggesting an increased water/glutamate-buffering capability.	Water	131-136	solute carrier family 1 member 2	Homo sapiens	5-10
24862482-10	2014	These results suggest that O3/UV FBR is efficient in removing residuals from CWWTP, thus reducing the accumulation of persistent pollutant released to surface water.	Water	159-164	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	27-36
24992835-10	2014	These data suggest that increases in TLR4 expression induced by drinking DSS-treated water might be directly or indirectly associated with NO overproduction.	Water	85-90	toll-like receptor 4	Mus musculus	37-41
24888323-1	2014	OBJECTIVE: This study was conducted to evaluate the effect of the synthetic water-soluble phenolic antioxidant TS-13 (sodium 3-(4"-methoxyphenyl)propyl thiosulfonate), an inducer of the redox-dependent Keap1/Nrf2/ARE signaling system, in experimental models of acute and chronic inflammation.	Water	76-81	NFE2 like bZIP transcription factor 2	Rattus norvegicus	208-212
24948644-0	2014	Aquaporin expression in the Japanese medaka (Oryzias latipes) in freshwater and seawater: challenging the paradigm of intestinal water transport?	Water	70-75	aquaporin-8	Oryzias latipes	0-9
24948644-12	2014	The strong decrease in aquaporin expression in the intestine of SW fish is surprising, and challenges the paradigm for transepithelial intestinal water absorption in SW fishes.	Water	146-151	aquaporin-8	Oryzias latipes	23-32
24907557-5	2014	Knock down of claudin 2 by shRNA had no discernable effect on TEER or dome formation but severely attenuated apical to basolateral water reabsorption when cultured on microporous filters.	Water	131-136	claudin 2	Homo sapiens	14-23
25034026-0	2014	Synthesis of water-soluble CdSe quantum dots with various fluorescent properties and their application in immunoassay for determination of C-reactive protein.	Water	13-18	C-reactive protein	Homo sapiens	139-157
24845055-0	2014	Human aquaporin-11 is a water and glycerol channel and localizes in the vicinity of lipid droplets in human adipocytes.	Water	24-29	aquaporin 11	Homo sapiens	6-18
24845055-7	2014	Overexpression of hAQP11 in 3T3-L1 adipocytes enabled to validate its function as a water channel and reveal its glycerol permeation activity.	Water	84-89	aquaporin 11	Homo sapiens	18-24
24845055-8	2014	CONCLUSIONS: hAQP11 permeates both water and glycerol, localizing in the vicinity of lipid droplets in human adipocytes.	Water	35-40	aquaporin 11	Homo sapiens	13-19
24907557-6	2014	Generation of an osmotic gradient in the basolateral compartment rescued water transport in claudin 2 knock down cells.	Water	73-78	claudin 2	Homo sapiens	92-101
24907557-10	2014	In conclusion, this study provides strong evidence that claudin 2 is involved in paracellular water transport and that claudin 2 expression is sensitive to compound induced cellular stress.	Water	94-99	claudin 2	Homo sapiens	56-65
25093545-10	2014	A broad adaptation pH range for both As(V) and As(III) adsorbed by the resulting product indicates its promising application perspective for decontamination of arsenic-polluted water.	Water	177-182	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-42
25327021-6	2014	In the sludge, the NO3- followed the spatial and seasonal pattern recorded in the surface water: detectable concentrations in the warmer months at the outlet.	Water	90-95	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
25051237-5	2014	Dietary intake was the main exposure source to DEP, BBP, DEHP and DOP, whereas water ingestion/absorption was the major source of exposure to DBP, DEHP and DOP.	Water	79-84	D-box binding PAR bZIP transcription factor	Homo sapiens	142-145
25091588-6	2014	Hence, we have developed a "green synthesis" method for preparing water-soluble curcumin nanoparticles to stabilize recombinant IkappaBalpha protein.	Water	66-71	NFKB inhibitor alpha	Homo sapiens	128-140
25170825-8	2014	We also found that 7,8,4"-THIF significantly alleviated DNCB-induced loss of water through the epidermal layer.	Water	77-82	thioredoxin interacting protein	Mus musculus	26-30
24976597-0	2014	epi-Fluorescence imaging at the air-water interface of fibrillization of bovine serum albumin and human insulin.	Water	36-41	insulin	Homo sapiens	104-111
24977405-5	2014	Herein, we report the synthesis of cell-permeable, water-soluble amphiphilic porphyrin - Plk1 specific peptide bioconjugates, Por-P1 and Por-P2.	Water	51-56	cytochrome p450 oxidoreductase	Homo sapiens	126-129
24977405-5	2014	Herein, we report the synthesis of cell-permeable, water-soluble amphiphilic porphyrin - Plk1 specific peptide bioconjugates, Por-P1 and Por-P2.	Water	51-56	cytochrome p450 oxidoreductase	Homo sapiens	137-140
25101792-6	2014	The spatially resolved fluorescence lifetime and anisotropy decay data for an NOP water glass interfacial structure exhibits the absence of a gradient in the anisotropy decay profile normal to the NOP water interface and the presence of a fluorescence lifetime gradient as a function of distance from the NOP water interface.	Water	82-87	prepronociceptin	Homo sapiens	78-81
25101792-6	2014	The spatially resolved fluorescence lifetime and anisotropy decay data for an NOP water glass interfacial structure exhibits the absence of a gradient in the anisotropy decay profile normal to the NOP water interface and the presence of a fluorescence lifetime gradient as a function of distance from the NOP water interface.	Water	201-206	prepronociceptin	Homo sapiens	78-81
25101792-6	2014	The spatially resolved fluorescence lifetime and anisotropy decay data for an NOP water glass interfacial structure exhibits the absence of a gradient in the anisotropy decay profile normal to the NOP water interface and the presence of a fluorescence lifetime gradient as a function of distance from the NOP water interface.	Water	201-206	prepronociceptin	Homo sapiens	78-81
25101792-7	2014	The compositional heterogeneity for both interfacial systems is in the form of water nanodroplets in the NOP phase.	Water	79-84	prepronociceptin	Homo sapiens	105-108
26278096-5	2014	The evolution of the 2DIR line shape as a function of waiting time is well described in terms of the orientational dynamics of the water molecules, with chemical exchange cross peaks appearing at a time scale similar to the hydrogen bond rearrangement lifetime.	Water	131-136	arginine vasopressin receptor 2	Homo sapiens	22-25
24976597-3	2014	In this study, epi-fluorescence at the air-water interface was developed as an innovative technique for observing fibrillization of bovine serum albumin and human insulin.	Water	43-48	insulin	Homo sapiens	163-170
24965793-6	2014	The increase in water intake was ANG II type 1 receptor-dependent.	Water	16-21	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	33-39
24959968-7	2014	These findings suggest that the water-mediated interactions and the intermolecular interactions influence the binding affinity of different disaccharides with FGF2, correlating with their respective dissociation constants in solution.	Water	32-37	fibroblast growth factor 2	Homo sapiens	159-163
24944242-1	2014	A regulatory effect of arginine vasopressin (AVP) on sweat water conservation has been hypothesized but not definitively evaluated.	Water	59-64	arginine vasopressin	Homo sapiens	32-43
24944242-2	2014	AVP-mediated insertion of sweat and salivary gland aquaporin-5 (AQP5) water channels through activation of the vasopressin type 2 receptor (V2R) remains an attractive, yet unexplored, mechanism that could result in a more concentrated sweat with resultant decreased water loss.	Water	70-75	arginine vasopressin receptor 2	Homo sapiens	111-143
24952955-5	2014	The simultaneous blockade of endothelin ETB receptors might not be advantageous, leading possibly to vasoconstriction and salt and water retentions.	Water	131-136	endothelin receptor type B	Homo sapiens	40-43
25068977-10	2014	Second, SBMA@CNT improve water uptake and adjust water state of membrane, which further increases CO2 permeability.	Water	25-30	androgen receptor	Homo sapiens	8-12
25016163-1	2014	Tolvaptan is a competitive vasopressin V2-receptor antagonist that inhibits water reabsorption in the renal collecting ducts.	Water	76-81	arginine vasopressin receptor 2	Rattus norvegicus	27-50
24858219-1	2014	Water pollution in the form of nitrate nitrogen (NO3(-)-N) contamination is a major concern in most agricultural areas in the world.	Water	0-5	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
24858219-3	2014	Concentrations of NO3(-)-N ranged from 0.2 to 29.6 mg/L (mean of 11.2 mg/L) in surface water, and from 0.1 to 19.4 mg/L (mean of 2.8 mg/L) in groundwater.	Water	87-92	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
25232381-6	2014	RESULTS: In the Ngb plasmid and hemin joint intervention group, there were significant reductions (i.e., improvements) in neurobehavioral scores, brain water content, and infarct volume ratio.	Water	152-157	neuroglobin	Rattus norvegicus	16-19
25134597-6	2014	Using the SPC/E model for water and TraPPE model for alkanes along with Lorentz-Berthelot mixing rules for the cross parameters produces a water solubility that is an order of magnitude lower than the experimental value.	Water	26-31	proline rich protein gene cluster	Homo sapiens	10-13
25134597-6	2014	Using the SPC/E model for water and TraPPE model for alkanes along with Lorentz-Berthelot mixing rules for the cross parameters produces a water solubility that is an order of magnitude lower than the experimental value.	Water	139-144	proline rich protein gene cluster	Homo sapiens	10-13
25134597-8	2014	This number is much higher than used in most simulation water models (SPC/E-epsilon(W)/k = 78.2 K).	Water	56-61	proline rich protein gene cluster	Homo sapiens	70-73
25068977-10	2014	Second, SBMA@CNT improve water uptake and adjust water state of membrane, which further increases CO2 permeability.	Water	49-54	androgen receptor	Homo sapiens	8-12
24894646-5	2014	The trends of characteristic protein expression, including that of nestin, vimentin, GFAP and glutamine synthetase, for astrocytes cultured on super water-repellent fractal PPP surfaces approximate more to in vivo pattern.	Water	149-154	nestin	Homo sapiens	67-73
25019986-6	2014	In vivo, PDE4B deletion could attenuate the lung water content, histological signs of pulmonary injury and elevate the ratio of partial pressure of arterial O2 to fraction of inspired O2 (PaO2/FIO2 ratio).	Water	49-54	phosphodiesterase 4B	Homo sapiens	9-14
25095792-15	2014	In addition, non-modified Cyt c was more susceptible to denaturation by a water-organic solvent interface than its glycoconjugates, important for the formulation in polymers.	Water	74-79	cytochrome c, somatic	Homo sapiens	26-31
25084328-7	2014	A putative catalytic mechanism of Coq5 was proposed in which Arg201 acts as a general base to initiate catalysis with the help of a water molecule.	Water	132-137	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase	Saccharomyces cerevisiae S288C	34-38
25008554-5	2014	The transcript levels of PGK and NADP-GAPDH decreased and that of glucose-6-phosphate isomerase (GPI), PGM, and PFK increased in response to water-deficit stress while water-deficit stress had no effect on the steady-state transcript levels of hexokinase, aldolase, TPI, and NAD-GAPDH.	Water	141-146	fructose-bisphosphate aldolase 1, chloroplastic	Cicer arietinum	256-264
32261784-2	2014	The PNIPAM-b-LCP/SDS-functionalized 5CB droplets were effective in detecting proteins in water through a radial-to-bipolar (R-B) orientational change, with detection limits of 0.95, 1.1, 0.12, and 0.07 muM for bovine serum albumin (BSA), lysozyme (LYZ), hemoglobin (Hb), and chymotrypsinogen (ChTg), respectively.	Water	89-94	albumin	Homo sapiens	217-230
32261784-2	2014	The PNIPAM-b-LCP/SDS-functionalized 5CB droplets were effective in detecting proteins in water through a radial-to-bipolar (R-B) orientational change, with detection limits of 0.95, 1.1, 0.12, and 0.07 muM for bovine serum albumin (BSA), lysozyme (LYZ), hemoglobin (Hb), and chymotrypsinogen (ChTg), respectively.	Water	89-94	lysozyme	Homo sapiens	238-246
32261784-2	2014	The PNIPAM-b-LCP/SDS-functionalized 5CB droplets were effective in detecting proteins in water through a radial-to-bipolar (R-B) orientational change, with detection limits of 0.95, 1.1, 0.12, and 0.07 muM for bovine serum albumin (BSA), lysozyme (LYZ), hemoglobin (Hb), and chymotrypsinogen (ChTg), respectively.	Water	89-94	lysozyme	Homo sapiens	248-251
25099799-0	2014	Characterization of a novel water pocket inside the human Cx26 hemichannel structure.	Water	28-33	gap junction protein beta 2	Homo sapiens	58-62
25099799-5	2014	In this work, we describe the identification and characterization of a believed novel water pocket-termed the IC pocket-located in-between the four transmembrane helices of each human Cx26 (hCx26) monomer at the intracellular (IC) side.	Water	86-91	gap junction protein beta 2	Homo sapiens	184-188
25099799-5	2014	In this work, we describe the identification and characterization of a believed novel water pocket-termed the IC pocket-located in-between the four transmembrane helices of each human Cx26 (hCx26) monomer at the intracellular (IC) side.	Water	86-91	gap junction protein beta 2	Homo sapiens	190-195
25099799-6	2014	Using molecular dynamics (MD) simulations to characterize hCx26 internal water structure and dynamics, six IC pockets were identified per hemichannel.	Water	73-78	gap junction protein beta 2	Homo sapiens	58-63
24894646-5	2014	The trends of characteristic protein expression, including that of nestin, vimentin, GFAP and glutamine synthetase, for astrocytes cultured on super water-repellent fractal PPP surfaces approximate more to in vivo pattern.	Water	149-154	glutamate-ammonia ligase	Homo sapiens	94-114
24920569-7	2014	However, the truncation of the CTR results in an extreme alteration of global stability and protein dynamics over a vast range of timescales and encompassing regions far from the CTR, as shown by proton-water exchange rates and (15) N-relaxation measurements.	Water	203-208	calcitonin receptor	Homo sapiens	31-34
24840884-1	2014	PURPOSE OF REVIEW: The purpose of this review is to describe the renin-angiotensin-aldosterone system and its regulatory control of sodium, potassium, chloride, hydrogen ion, and water homeostasis through its effects on the expression and activity of distal renal tubular cotransporter proteins and to discuss the gene mutations encoding these structures that disturb the function of this system.	Water	179-184	renin	Homo sapiens	65-70
25016644-5	2014	Finally, we exploited a convenient approach for preparing water-soluble GNRs with less toxicity, better dispersion and flexible functionalization by exchanging hexadecyltrimethylammonium bromide (CTAB) on the surface of the rods with carboxylated bovine serum albumin (BSA) derivative, the BSA modified GNRs showed significant anticancer efficacy through near infrared (NIR) hyperthermia.	Water	58-63	albumin	Homo sapiens	254-267
25179972-1	2014	The vasopressin V2 receptor antagonist (Tolvaptan) is a new diuretic that selectively promotes the excretion of water.	Water	112-117	arginine vasopressin receptor 2	Homo sapiens	4-27
25338366-4	2014	Meanwhile, with the depth increase in water column, the DIC concentration increased gradually (DIC(Average) : from 0.86 to 1.05 mmol x L(-1)) and the delta13C(DIC) decreased gradually (delta13C(DIC(Average) : from -7.88 per thousand to -13.39 per thousand) from the surface to the bottom of the reservoir.	Water	38-43	solute carrier family 25 member 10	Homo sapiens	56-59
25338366-4	2014	Meanwhile, with the depth increase in water column, the DIC concentration increased gradually (DIC(Average) : from 0.86 to 1.05 mmol x L(-1)) and the delta13C(DIC) decreased gradually (delta13C(DIC(Average) : from -7.88 per thousand to -13.39 per thousand) from the surface to the bottom of the reservoir.	Water	38-43	solute carrier family 25 member 10	Homo sapiens	95-98
25338366-4	2014	Meanwhile, with the depth increase in water column, the DIC concentration increased gradually (DIC(Average) : from 0.86 to 1.05 mmol x L(-1)) and the delta13C(DIC) decreased gradually (delta13C(DIC(Average) : from -7.88 per thousand to -13.39 per thousand) from the surface to the bottom of the reservoir.	Water	38-43	solute carrier family 25 member 10	Homo sapiens	150-163
25338366-4	2014	Meanwhile, with the depth increase in water column, the DIC concentration increased gradually (DIC(Average) : from 0.86 to 1.05 mmol x L(-1)) and the delta13C(DIC) decreased gradually (delta13C(DIC(Average) : from -7.88 per thousand to -13.39 per thousand) from the surface to the bottom of the reservoir.	Water	38-43	solute carrier family 25 member 10	Homo sapiens	95-98
25338370-0	2014	[Influence of inorganic ions and humic acid on the removal of Pb(II) and Hg(II) in water by zero-valent iron].	Water	83-88	submaxillary gland androgen regulated protein 3B	Homo sapiens	62-68
25338370-1	2014	The effects of Ca2+, Cl- and humic acid (HA) on the removal rates of Pb(II) and Hg(II) in water by zero-valent (ZVI) and the kinetic characteristics were studied, and the removal mechanism of Pb(II) and Hg(II) by ZVI were preliminarily investigated using X-ray diffraction (XRD).	Water	90-95	submaxillary gland androgen regulated protein 3B	Homo sapiens	69-75
25108711-7	2014	Because PFASs have hydrophilic groups and relatively high solubility, the PFASs will transfer from the upper to lower layers of sediment when water infiltration occurs, leading to the fluctuation of PFAS levels in sediment cores.	Water	142-147	phosphoribosylformylglycinamidine synthase	Homo sapiens	8-12
25080850-2	2014	The present study aimed to assess if apelin-13 is an upstream signal regulation factor of aquaporin 7 (AQP7), a water-glycerol transporter present in the plasma membrane of adipocytes that plays a key role in the regulation of lipid accumulation.	Water	112-117	apelin	Homo sapiens	37-43
24771509-6	2014	These miRs silenced ZO-1 and ZO-2 to compromise tight junction function, resulting in leaky skin as measured by transepidermal water loss (TEWL).	Water	127-132	tight junction protein 1	Homo sapiens	20-24
23736674-2	2014	The discovery of underlying genes identified key molecules involved in urinary concentration, including the type 2 vasopressin receptor AVPR2 and the water channel AQP2, which constitute obvious pharmacologic targets.	Water	150-155	arginine vasopressin receptor 2	Homo sapiens	136-141
24945466-0	2014	Regulation of cell volume and water transport--an old fundamental role of the renin angiotensin aldosterone system components at the cellular level.	Water	30-35	renin	Homo sapiens	78-83
24549822-5	2014	RESULTS: Volunteer self-application of the 400 mum microneedle design resulted in an approximately 30% increase in skin transepidermal water loss, which was not significantly different from that seen with self-application by the more experienced researchers or application to the volunteers.	Water	135-140	latexin	Homo sapiens	47-50
24945466-1	2014	The expression and the role of renin angiotensin aldosterone system (RAAS) components on regulation of cell volume and water transport on vertebrates and invertebrates were reviewed.	Water	119-124	renin	Homo sapiens	31-36
25423832-3	2014	Water was used as mobile phase, the flow rate was 0.7 mL x min(-1), and the temperature was set at 30 C. The evaporated light scattering detector was adopted.	Water	0-5	CD59 molecule (CD59 blood group)	Homo sapiens	59-65
25098339-8	2014	The Gln7.42 at hH4R disrupts a water chain, connecting the Asp3.32 of the orthosteric binding site and the Asp2.50 of the allosteric binding site.	Water	31-36	beta-secretase 1	Homo sapiens	107-111
24956138-3	2014	In this work, the ionization potentials (IPs) of the S-NPC1161 (NPC1161a) hydroxylated derivatives, which are possible metabolites derived from action of endogenous cytochrome P450 (CYP450) enzymes, were calculated at the B3LYP-SCRF(PCM)/6-311++G**//B3LYP/6-31G** level in water.	Water	273-278	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	165-180
24915296-0	2014	Orexin-1 receptor mediates the increased food and water intake induced by intracerebroventricular injection of the stable somatostatin pan-agonist, ODT8-SST in rats.	Water	50-55	hypocretin neuropeptide precursor	Rattus norvegicus	0-6
24915296-5	2014	The orexin-1 receptor antagonist, SB-334867 (16mug/rat, icv) completely inhibited the 2-h food and water intake induced by icv ODT8-SST.	Water	99-104	hypocretin neuropeptide precursor	Rattus norvegicus	4-10
24901947-0	2014	Oil-in-water microemulsion droplets of TDMAO/decane interconnected by the telechelic C18-EO150-C18: clustering and network formation.	Water	7-12	Bardet-Biedl syndrome 9	Homo sapiens	85-88
24901947-0	2014	Oil-in-water microemulsion droplets of TDMAO/decane interconnected by the telechelic C18-EO150-C18: clustering and network formation.	Water	7-12	Bardet-Biedl syndrome 9	Homo sapiens	95-98
24901947-1	2014	The effect of a doubly hydrophobically end-capped water soluble polymer (C18-PEO150-C18) on the properties of an oil-in-water (O/W) droplet microemulsion (R ~ 2.85 nm) has been studied as a function of the amount of added telechelic polymer.	Water	50-55	Bardet-Biedl syndrome 9	Homo sapiens	73-76
24901947-1	2014	The effect of a doubly hydrophobically end-capped water soluble polymer (C18-PEO150-C18) on the properties of an oil-in-water (O/W) droplet microemulsion (R ~ 2.85 nm) has been studied as a function of the amount of added telechelic polymer.	Water	50-55	Bardet-Biedl syndrome 9	Homo sapiens	84-87
24901947-1	2014	The effect of a doubly hydrophobically end-capped water soluble polymer (C18-PEO150-C18) on the properties of an oil-in-water (O/W) droplet microemulsion (R ~ 2.85 nm) has been studied as a function of the amount of added telechelic polymer.	Water	120-125	Bardet-Biedl syndrome 9	Homo sapiens	73-76
24901947-1	2014	The effect of a doubly hydrophobically end-capped water soluble polymer (C18-PEO150-C18) on the properties of an oil-in-water (O/W) droplet microemulsion (R ~ 2.85 nm) has been studied as a function of the amount of added telechelic polymer.	Water	120-125	Bardet-Biedl syndrome 9	Homo sapiens	84-87
25043186-1	2014	Homeostatic control of extracellular fluid osmolality in rats requires a parallel excitation of vasopressin (VP) and oxytocin (OT) neurosecretory neurons by osmoreceptor afferents to regulate the amount of water and sodium in the urine under normal conditions.	Water	206-211	arginine vasopressin	Rattus norvegicus	96-107
25043186-1	2014	Homeostatic control of extracellular fluid osmolality in rats requires a parallel excitation of vasopressin (VP) and oxytocin (OT) neurosecretory neurons by osmoreceptor afferents to regulate the amount of water and sodium in the urine under normal conditions.	Water	206-211	arginine vasopressin	Rattus norvegicus	109-111
24956138-3	2014	In this work, the ionization potentials (IPs) of the S-NPC1161 (NPC1161a) hydroxylated derivatives, which are possible metabolites derived from action of endogenous cytochrome P450 (CYP450) enzymes, were calculated at the B3LYP-SCRF(PCM)/6-311++G**//B3LYP/6-31G** level in water.	Water	273-278	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	182-188
25000594-0	2014	Green cobalt oxide (CoOx) film with nanoribbon structures electrodeposited from the BF2-annulated cobaloxime precursor for efficient water oxidation.	Water	133-138	forkhead box G1	Homo sapiens	84-87
25000594-1	2014	In this study, we report for the first time on the use of a water-soluble BF2-annulated cobaloxime, Co(dmgBF2)2(OH2)2 (Co-DMB, dmgBF2 = difluoroboryl-dimethylglyoxime), as a catalyst precursor for electrocatalytic water oxidation.	Water	60-65	forkhead box G1	Homo sapiens	74-77
25000594-1	2014	In this study, we report for the first time on the use of a water-soluble BF2-annulated cobaloxime, Co(dmgBF2)2(OH2)2 (Co-DMB, dmgBF2 = difluoroboryl-dimethylglyoxime), as a catalyst precursor for electrocatalytic water oxidation.	Water	214-219	forkhead box G1	Homo sapiens	74-77
24479585-2	2014	We present here a comparison of the reorientation dynamics of individual water molecules within the hydration shell of a series of globular proteins: acetylcholinesterase, subtilisin Carlsberg, lysozyme, and ubiquitin.	Water	73-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-170
25053332-7	2014	Of these two cases, the model predictions for the solvent-induced potential of mean force between two solutes in associated liquids are closer to the results of molecular dynamics simulation of hydrophobic interactions in the SPC/E model water.	Water	238-243	proline rich protein gene cluster	Homo sapiens	226-229
24833711-2	2014	In patients with hypoalbuminemia due to underlying cirrhosis, the decrease in the plasma water albumin concentration ([Alb-]pw) would be expected to result in a decrease in the plasma water sodium concentration ([Na+]pw) due to an alteration in the distribution of Na+ between the plasma and ISF.	Water	89-94	albumin	Homo sapiens	21-28
24598363-2	2014	Short-term regulation of water transport is dependent on vasopressin-induced phosphorylation of aquaporin-2 (AQP2) at Ser256.	Water	25-30	arginine vasopressin	Rattus norvegicus	57-68
24631653-2	2014	Peroxiredoxin2 (PRX2) is one of six mammalian isoenzymes (PRX1-6) that can reduce hydrogen peroxide (H2O2) and organic hydroperoxides to water and alcohols.	Water	137-142	peroxiredoxin 2	Homo sapiens	0-14
24863789-10	2014	This study suggests that the modified sineguelas waste by NZVI particles can be prepared at low cost and the materials are environmentally benign for the removal of Pb(II) ions, and likely many other heavy metal ions, from water.	Water	223-228	submaxillary gland androgen regulated protein 3B	Homo sapiens	165-171
25028029-5	2014	Compared to commonly used water models such as SPC/E and TIP4P, the new model shows better agreement with experiment for many physical properties including liquid density, melting temperature, virial coefficients, etc.	Water	26-31	proline rich protein gene cluster	Homo sapiens	47-50
25000400-5	2014	Soil storage water averages at 0-20, 20-40 and 40-60 cm were observed to be 490.2, 593.8, and 358 m3 ha-1, respectively, during the growing season.	Water	13-18	1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic	Zea mays	101-105
24985889-4	2014	Here, we report a SNARE protein-based method for incorporation of multiple membrane proteins into artificial membrane vesicles of well-defined composition, and for delivery of large water-soluble substrates into these vesicles.	Water	182-187	small NF90 (ILF3) associated RNA E	Homo sapiens	18-23
24625878-0	2014	Effects of natural mineral-rich water consumption on the expression of sirtuin 1 and angiogenic factors in the erectile tissue of rats with fructose-induced metabolic syndrome.	Water	32-37	sirtuin 1	Rattus norvegicus	71-80
24625878-6	2014	Mineral-rich water ingestion (FRUCTMIN) increased the proportion of smooth muscle cells compared with FRUCT rats and induced an upregulatory tendency of sirtuin 1 expression compared with the control and FRUCT groups.	Water	13-18	sirtuin 1	Rattus norvegicus	153-162
24857763-2	2014	Here, we report the synthesis and the self-assembly properties in water of chondroitin sulfate-b-poly(lactic acid) (CS-b-PLA(n)).	Water	66-71	chorionic somatomammotropin hormone 2	Homo sapiens	116-120
24849815-1	2014	The activation of F-BODIPYs with boron trihalides, followed by treatment with a nucleophile, effects facile substitution at boron; using water as the nucleophile promotes deprotective removal of the -BF2 moiety and thereby production of the corresponding parent dipyrrin salt in quantitative yield under extremely mild conditions.	Water	137-142	forkhead box G1	Homo sapiens	200-203
24957269-9	2014	Inhibitory activity of one of these water-soluble Au(III) complexes towards deubiquitinase (DUB) UCHL3 has been investigated; this complex also displayed a significant inhibitory activity with IC50 value of 0.15 muM.	Water	36-41	ubiquitin C-terminal hydrolase L3	Homo sapiens	97-102
25024004-5	2014	Essentially, T-lymphocytes determine an increase in angiotensin ii production which raises sodium and water retention.	Water	102-107	angiotensinogen	Homo sapiens	52-66
24631653-2	2014	Peroxiredoxin2 (PRX2) is one of six mammalian isoenzymes (PRX1-6) that can reduce hydrogen peroxide (H2O2) and organic hydroperoxides to water and alcohols.	Water	137-142	peroxiredoxin 2	Homo sapiens	16-20
24837571-6	2014	In contrast to common changes, the presynaptic vesicular neurotransmitter transporters VGAT and Vglut1 were upregulated after extinction in water- and fluoxetine-treated mice, respectively.	Water	140-145	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	Mus musculus	96-102
25707244-3	2014	The impact of this water on biochemical indicators (AST, ALT, alkaline phosphatase, creatinine, bilirubin) and dynamics in body weight of laboratory animals within 42 days is established.	Water	19-24	solute carrier family 17 member 5	Homo sapiens	52-55
25110213-7	2014	RESULTS: Angiotensin II administration resulted in an increase in blood pressure, heart weight/body weight index, and water intake in comparison with controls.	Water	118-123	angiotensinogen	Rattus norvegicus	9-23
24837571-7	2014	The cortical levels of the GABA transporter Gat1 were reduced in high-freezing water-drinking mice, suggesting a maladaptive increase of GABA spillover at cortical inhibitory synapses.	Water	79-84	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	44-48
24984066-0	2014	Deep-sea water containing selenium provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase 1.	Water	9-14	BCL2, apoptosis regulator	Rattus norvegicus	118-123
32481028-6	2014	Water deficit significantly increased surperoxide radical production rate (O2- ) and hydrogen peroxide content (H2O2), and the activities of superoxide dismutase (SOD), ascorbate peroxidase (APX), peroxidase (POD) and catalase (CAT) in cotton leaves also increased under water deficit.	Water	0-5	peroxidase 42-like	Gossypium hirsutum	179-189
32481028-6	2014	Water deficit significantly increased surperoxide radical production rate (O2- ) and hydrogen peroxide content (H2O2), and the activities of superoxide dismutase (SOD), ascorbate peroxidase (APX), peroxidase (POD) and catalase (CAT) in cotton leaves also increased under water deficit.	Water	0-5	peroxidase 42-like	Gossypium hirsutum	197-207
32481028-6	2014	Water deficit significantly increased surperoxide radical production rate (O2- ) and hydrogen peroxide content (H2O2), and the activities of superoxide dismutase (SOD), ascorbate peroxidase (APX), peroxidase (POD) and catalase (CAT) in cotton leaves also increased under water deficit.	Water	0-5	peroxidase 42-like	Gossypium hirsutum	209-212
32481028-6	2014	Water deficit significantly increased surperoxide radical production rate (O2- ) and hydrogen peroxide content (H2O2), and the activities of superoxide dismutase (SOD), ascorbate peroxidase (APX), peroxidase (POD) and catalase (CAT) in cotton leaves also increased under water deficit.	Water	0-5	catalase isozyme 1-like	Gossypium hirsutum	218-226
32481028-6	2014	Water deficit significantly increased surperoxide radical production rate (O2- ) and hydrogen peroxide content (H2O2), and the activities of superoxide dismutase (SOD), ascorbate peroxidase (APX), peroxidase (POD) and catalase (CAT) in cotton leaves also increased under water deficit.	Water	0-5	catalase isozyme 1-like	Gossypium hirsutum	228-231
24983378-0	2014	Alum and squalene-oil-in-water emulsion enhance the titer and avidity of anti-Abeta antibodies induced by multimeric protein antigen (1-11)E2, preserving the Igg1-skewed isotype distribution.	Water	25-30	histocompatibility 2, class II antigen A, beta 1	Mus musculus	78-83
25842512-1	2014	The study of the structural state of tap water that has been stored for two days in the packaging materials of various type and in different conditions, was performed with the use of crystallographic method for the investigation of liquids based on a special approach for dehydration of the drop, which is a fixed thin "slice" of the examines liquid.	Water	41-46	SEC14 like lipid binding 2	Homo sapiens	37-40
25560240-6	2014	Over a seven-week period, animals had access to one of the following three drinking solutions: 1) tap water (control group; TW), 2) tap water with added Na(+) (to make the same concentration as in the MW group (TWNaCl group), or 3) natural mineral-rich water [Pedras Salgadas( ), which is very rich in bicarbonate, and with higher sodium, calcium and magnesium content than control tap water (MW group)].	Water	136-141	nuclear RNA export factor 1	Rattus norvegicus	132-135
25560240-6	2014	Over a seven-week period, animals had access to one of the following three drinking solutions: 1) tap water (control group; TW), 2) tap water with added Na(+) (to make the same concentration as in the MW group (TWNaCl group), or 3) natural mineral-rich water [Pedras Salgadas( ), which is very rich in bicarbonate, and with higher sodium, calcium and magnesium content than control tap water (MW group)].	Water	136-141	nuclear RNA export factor 1	Rattus norvegicus	132-135
25560240-6	2014	Over a seven-week period, animals had access to one of the following three drinking solutions: 1) tap water (control group; TW), 2) tap water with added Na(+) (to make the same concentration as in the MW group (TWNaCl group), or 3) natural mineral-rich water [Pedras Salgadas( ), which is very rich in bicarbonate, and with higher sodium, calcium and magnesium content than control tap water (MW group)].	Water	136-141	nuclear RNA export factor 1	Rattus norvegicus	132-135
25560240-6	2014	Over a seven-week period, animals had access to one of the following three drinking solutions: 1) tap water (control group; TW), 2) tap water with added Na(+) (to make the same concentration as in the MW group (TWNaCl group), or 3) natural mineral-rich water [Pedras Salgadas( ), which is very rich in bicarbonate, and with higher sodium, calcium and magnesium content than control tap water (MW group)].	Water	136-141	nuclear RNA export factor 1	Rattus norvegicus	132-135
25560240-6	2014	Over a seven-week period, animals had access to one of the following three drinking solutions: 1) tap water (control group; TW), 2) tap water with added Na(+) (to make the same concentration as in the MW group (TWNaCl group), or 3) natural mineral-rich water [Pedras Salgadas( ), which is very rich in bicarbonate, and with higher sodium, calcium and magnesium content than control tap water (MW group)].	Water	136-141	nuclear RNA export factor 1	Rattus norvegicus	132-135
25560240-6	2014	Over a seven-week period, animals had access to one of the following three drinking solutions: 1) tap water (control group; TW), 2) tap water with added Na(+) (to make the same concentration as in the MW group (TWNaCl group), or 3) natural mineral-rich water [Pedras Salgadas( ), which is very rich in bicarbonate, and with higher sodium, calcium and magnesium content than control tap water (MW group)].	Water	136-141	nuclear RNA export factor 1	Rattus norvegicus	132-135
24984066-8	2014	Drinking DSW600, DSW1200, and selenium water but not Mg2+ water significantly enhanced Bcl-2 and thioredoxin reductase 1 expression.	Water	39-44	BCL2, apoptosis regulator	Rattus norvegicus	87-92
24664104-0	2014	A Co(II)-Ru(II) dyad relevant to light-driven water oxidation catalysis.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
24927545-9	2014	Higher water availability induces the biosynthesis and transport of the lateral root-inductive signal auxin through local regulation of tryptophan aminotransferase of Arabidopsis 1 and PIN-formed 3, both of which are necessary for normal hydropatterning.	Water	7-12	Auxin efflux carrier family protein	Arabidopsis thaliana	167-197
24819564-1	2014	A homogeneous solution of Co(II) in acetate buffer at pH 7 is found to be an efficient water oxidation catalyst (WOC) showing significantly greater current density than Co(II) in phosphate buffer (Co-Pi) under identical conditions owing to the higher solubility of the former.	Water	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
25161869-1	2014	Aquaporin 9 (AQP9) is a member of the aquaglyceroporin family that transports glycerol, urea and other small solutes as well as water.	Water	128-133	aquaporin 9	Homo sapiens	0-11
25161869-1	2014	Aquaporin 9 (AQP9) is a member of the aquaglyceroporin family that transports glycerol, urea and other small solutes as well as water.	Water	128-133	aquaporin 9	Homo sapiens	13-17
24928241-12	2014	The GO@SiO2 was used for analysis of various water samples by flame atomic absorption spectrometry with excellent enrichment factors (200-250) and detection limits (0.084 and 0.27 ng mL(-1) for Cu(II) and Pb(II), respectively).	Water	45-50	submaxillary gland androgen regulated protein 3B	Homo sapiens	194-211
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	Water	240-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24770345-0	2014	Water-soluble DNA minor groove binders as potential chemotherapeutic agents: synthesis, characterization, DNA binding and cleavage, antioxidation, cytotoxicity and HSA interactions.	Water	0-5	albumin	Homo sapiens	164-167
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	Water	253-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24797689-0	2014	An unusual water-bridged homospin Co(II) single-chain magnet.	Water	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
24946684-4	2014	In previous studies, we have found that the expression of CKLF1 increased in rats after focal cerebral ischemia and treatment with the CKLF1 antagonist C19 peptide decreased the infarct size and water content.	Water	195-200	chemokine-like factor	Rattus norvegicus	58-63
24946684-4	2014	In previous studies, we have found that the expression of CKLF1 increased in rats after focal cerebral ischemia and treatment with the CKLF1 antagonist C19 peptide decreased the infarct size and water content.	Water	195-200	chemokine-like factor	Rattus norvegicus	135-140
32263800-5	2014	The bFGF-grafted PDA was analyzed using scanning electron microscopy, water contact angle measurements, and X-ray photoelectron spectroscopy.	Water	70-75	fibroblast growth factor 2	Homo sapiens	4-8
24857343-2	2014	Experimental studies reported that 1,2-(dimethoxymethano)fullerene (DMF), a water-soluble fullerene derivative, inhibits strongly Abeta peptide aggregation at the early stage.	Water	76-81	amyloid beta precursor protein	Homo sapiens	130-135
24797689-1	2014	An unusual water-bridged homospin Co(II) coordination polymer has been successfully assembled, which exhibits slow relaxation of the magnetization at low temperature.	Water	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
24780856-4	2014	The adsorption performance of PAS-GO was investigated in removing Pb(II) ions from water.	Water	83-88	submaxillary gland androgen regulated protein 3B	Homo sapiens	66-72
24933288-3	2014	Here we show that temperature treatment of mice for two days at 41 C, instead of 37 C, for 1-2 h during the inactive period, using a temperature controlled water bath stimulated phase-advance of peripheral clocks in the kidney, liver, and submandibular gland of PER2::LUCIFERASE mice.	Water	156-161	period circadian clock 2	Mus musculus	262-266
24933288-6	2014	The temperature pulse stimulation at 41 C, instead of 37 C water bath for 2 h led to the elevated expression of Per1 and Hsp70 in the peripheral tissue of mice.	Water	59-64	heat shock protein 1B	Mus musculus	121-126
24936787-14	2014	We also found a significant decrease in the expression of aquaporin-1, the predominant water channel in disc NP cells, with inflammatory stimulation.	Water	87-92	aquaporin 1	Bos taurus	58-69
24929414-4	2014	The use of heavy water and partly deuterated trehalose gives clear information on protein-trehalose interactions in the native state of lysozyme (at room temperature) and during the thermal denaturation process of lysozyme.	Water	17-22	lysozyme	Homo sapiens	136-144
24929414-4	2014	The use of heavy water and partly deuterated trehalose gives clear information on protein-trehalose interactions in the native state of lysozyme (at room temperature) and during the thermal denaturation process of lysozyme.	Water	17-22	lysozyme	Homo sapiens	214-222
24921901-0	2014	Demographic factors associated with perceptions about water safety and tap water consumption among adults in Santa Clara County, California, 2011.	Water	75-80	SEC14 like lipid binding 2	Homo sapiens	71-74
24907372-2	2014	However, much foraging in water, by both humans and other primates, is conducted in the shallows and at low speeds of locomotion that include elements of turning, as befits searching for cryptic or hidden foods within a patch.	Water	26-31	cripto, FRL-1, cryptic family 1	Homo sapiens	187-194
24881485-2	2014	On the basis of detailed structural analyses and thermodynamic measurements made in a comparison of pseudo-isostructural crystals (NO3 and BF4 salts), we herein discuss how ligand-exchange reactions take place in the crystal due to changes in water content and temperature.	Water	243-248	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
24629225-4	2014	The latter observation suggests that the presence of AQP3 in follicles of all categories, especially in the antral follicles, provides novel insights on the mechanisms that regulate the flow of water between cells during the formation of antral follicles in sheep.	Water	194-199	aquaporin-3	Ovis aries	53-57
32481821-3	2014	A high-resolution localization microscopy technique is extended here to probe the conformation of individual fibronectin (Fn) molecules at the glass-water interface under physiological buffer conditions.	Water	149-154	fibronectin 1	Homo sapiens	109-120
24901527-4	2014	Two homogenous water soluble polysaccharides (TPS1-2a and TPS1-2b) were obtained from TPS1 after purification with gel permeation, which gave a higher phagocytic effect than TPS2.	Water	15-20	tryptase alpha/beta 1	Homo sapiens	46-50
24901527-4	2014	Two homogenous water soluble polysaccharides (TPS1-2a and TPS1-2b) were obtained from TPS1 after purification with gel permeation, which gave a higher phagocytic effect than TPS2.	Water	15-20	tryptase alpha/beta 1	Homo sapiens	58-62
24901527-4	2014	Two homogenous water soluble polysaccharides (TPS1-2a and TPS1-2b) were obtained from TPS1 after purification with gel permeation, which gave a higher phagocytic effect than TPS2.	Water	15-20	tryptase alpha/beta 1	Homo sapiens	58-62
24921901-1	2014	The objective of this study was to examine differences in tap water consumption and perceptions of bottle versus tap water safety for Hispanics and non-Hispanic whites, as well as associations with other demographic characteristics.	Water	62-67	SEC14 like lipid binding 2	Homo sapiens	58-61
24921901-4	2014	Hispanics were less likely than non-Hispanic whites to primarily drink tap water (OR = 0.33; 95% CI, 0.11-0.99), although there was no significant difference in perceptions that bottled water is safer between these groups (OR = 0.50; 95% CI, 0.11-2.27).	Water	75-80	SEC14 like lipid binding 2	Homo sapiens	71-74
24921901-5	2014	Hispanics may be an important population for interventions promoting tap water consumption.	Water	73-78	SEC14 like lipid binding 2	Homo sapiens	69-72
24752243-1	2014	We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Abeta aggregates and Abeta fibrils.	Water	61-66	histocompatibility 2, class II antigen A, beta 1	Mus musculus	86-91
26983191-1	2014	Vitamin B12 (B12, cobalamin (Cbl)) is a water-soluble vitamin that requires complex mechanisms for its assimilation, blood transport and intracellular metabolism.	Water	40-45	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
26983191-1	2014	Vitamin B12 (B12, cobalamin (Cbl)) is a water-soluble vitamin that requires complex mechanisms for its assimilation, blood transport and intracellular metabolism.	Water	40-45	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	13-16
26819974-1	2014	Recent studies have outlined the use of eutectic solutions of lithium chloride in water to study microscopic dynamics of lysozyme in an aqueous solvent that is remarkably similar to pure water in many respects, yet allows experiments over a wide temperature range without solvent crystallization.	Water	82-87	lysozyme	Homo sapiens	121-129
24007934-10	2014	CONCLUSIONS: The patients randomised to the carbohydrate oral fluid or the water prior to the surgery demonstrated a significant but similar decrease in insulin sensitivity.	Water	75-80	insulin	Homo sapiens	153-160
24497082-5	2014	Tap water samples from a variety of sources were analyzed for trihalomethanes (THMs) to determine if they were causing the malformations.	Water	4-9	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	0-3
24833425-7	2014	Of all four items that form the TOR-BSST( ), the water swallow item contributed to the identification of dysphagia in 42.7% in acute and 29.0% in rehabilitation patients.	Water	49-54	RAR related orphan receptor C	Homo sapiens	32-35
24107458-3	2014	The aim of this study was to determine whether the risk of skin lesions in people exposed to iAs-contaminated water could be modified by the presence of single nucleotide polymorphisms in the NRF2 coding gene.	Water	110-115	NFE2 like bZIP transcription factor 2	Homo sapiens	192-196
25158499-8	2014	It was concluded that MIP could be employed as an effective material for the selective removal of Cd(II) ions from waste water.	Water	121-126	major intrinsic protein of lens fiber	Homo sapiens	22-25
24833425-11	2014	The TOR-BSST( ) water swallow item contributes largely to the total TOR-BSST( )"s screening score and in making the test highly accurate and reliable.	Water	16-21	RAR related orphan receptor C	Homo sapiens	4-7
24833425-11	2014	The TOR-BSST( ) water swallow item contributes largely to the total TOR-BSST( )"s screening score and in making the test highly accurate and reliable.	Water	16-21	RAR related orphan receptor C	Homo sapiens	68-71
24913396-2	2014	Deuterated water is used to label ubiquitin and cytochrome c with minimal effect on the observed charge state distribution (CSD), suggesting that the protein conformation is not being altered.	Water	11-16	cytochrome c, somatic	Homo sapiens	48-60
24583321-3	2014	The CAST gene polymorphisms affected meat colour, pH, water holding-capacity (WHC) and texture parameters (toughness, firmness, cohesiveness, chewiness, and resilience) measured in longissimus dorsi and semimembranosus muscles.	Water	54-59	calpastatin	Sus scrofa	4-8
25109203-3	2014	The average concentrations of NH4+ and NO3- in the first wash water were 46 mg N/L and 58 mg N/L, respectively, being reduced to 2.5 and 1.2 mg N/L after the last wash.	Water	62-67	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
25697243-6	2014	Hypothalamic osmoreceptors detect changes in plasma osmolality, regulating the secretion of Antidiuretic Hormone (ADH), which travels to the kidneys resulting in more water being reabsorbed into the blood; therefore, the kidney is the main regulator of water balance.	Water	167-172	arginine vasopressin	Homo sapiens	92-112
25697243-6	2014	Hypothalamic osmoreceptors detect changes in plasma osmolality, regulating the secretion of Antidiuretic Hormone (ADH), which travels to the kidneys resulting in more water being reabsorbed into the blood; therefore, the kidney is the main regulator of water balance.	Water	167-172	arginine vasopressin	Homo sapiens	114-117
24410726-0	2014	Comparison of protein-water interactions in psychrophilic, mesophilic, and thermophilic Fe-SOD.	Water	22-27	superoxide dismutase 1	Homo sapiens	91-94
24865489-5	2014	In this article, we evaluated the PBT properties of compounds reported to possess anti-fouling properties using QSAR (quantitative structure-activity relationship) prediction programs such as BIOWIN  (a biodegradation probability program), KOWWIN  (log octanol-water partition coefficient calculation program) and ECOSAR  (Ecological Structure Activity Relationship Programme).	Water	261-266	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	34-37
24754487-0	2014	Shear-stress-induced conformational changes of von Willebrand factor in a water-glycerol mixture observed with single molecule microscopy.	Water	74-79	von Willebrand factor	Homo sapiens	47-68
24754487-3	2014	In this paper, we develop and employ an approach to visualize the large-scale conformation of VWF in a (pressure-driven) Poiseuille flow of water-glycerol buffers with wide-field single molecule fluorescence microscopy as a function of shear stress.	Water	140-145	von Willebrand factor	Homo sapiens	94-97
24773055-3	2014	The picosecond experiments show the importance of the interactions of C30 with the medium, as well as the intramolecular events in the excited-state relaxation as evidenced by the increase in the global emission lifetime from ~0.5 ns in MeOH/H2O mixtures to 2.5 ns in THF, and to 1-3 ns when the dye is trapped within CDs and HSA cavities.	Water	242-245	albumin	Homo sapiens	326-329
24773055-5	2014	The rotational time decays clearly show the robustness of the formed complexes with CDs and HSA protein: ~170 ps in MeOH/H2O solvent mixtures, ~850 ps due to 1:1 and 1:2 beta-CD complexes, and 28 ns for HSA complexes.	Water	121-124	albumin	Homo sapiens	92-95
24764237-2	2014	Treatment of (Delta)2-H3[Au3Co2(L-cys)6] (H3[1 a]) with [Co3(aet)6](NO3)3 (aet=2-aminoethanethiolate) in water at pH 7 gave a 1:1 complex salt of [Co3(aet)6](3+) and [1 a](3-), retaining the Au(I)3Co(III)2 structure and chiral configurations of [1 a](3-).	Water	105-110	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	200-203
24657326-0	2014	Performance of an optimized Zr-based nanoparticle-embedded PSF blend hollow fiber membrane in treatment of fluoride contaminated water.	Water	129-134	insulin like growth factor binding protein 7	Homo sapiens	59-62
24618746-3	2014	These wavefunction calculations indicate that the ground state for the AtO(+) and AtO(+)-H2O systems is the Omega = 0(+) component of the (3)Sigma(-) LS state, which is quite well separated (by  0.5 eV) from the Omega = 1 components of the same state and from the Omega = 2 state related to the (1)Delta LS state (by  1 eV).	Water	89-92	splicing factor-like protein	Arabidopsis thaliana	71-74
24618746-3	2014	These wavefunction calculations indicate that the ground state for the AtO(+) and AtO(+)-H2O systems is the Omega = 0(+) component of the (3)Sigma(-) LS state, which is quite well separated (by  0.5 eV) from the Omega = 1 components of the same state and from the Omega = 2 state related to the (1)Delta LS state (by  1 eV).	Water	89-92	splicing factor-like protein	Arabidopsis thaliana	82-85
24754754-3	2014	Present calculations indicate that the potential energy surface in water solution is different from the one in the gas-phase, and only stepwise mechanism is observed in aqueous solution, i.e., monothiocarbonic acid (H2CO2S) is formed via monothiocarbonate (OCSOH(-), MTC) and its counterion, protonated water cluster, (H2O)nH3O(+).	Water	67-72	metallothionein 1A	Homo sapiens	267-270
24726373-10	2014	The result demonstrated the superiority of the optimized method for selective extraction of BPs in water samples at the ngL(-1) level.	Water	99-104	leucine rich repeat containing 4C	Homo sapiens	120-126
24885203-2	2014	We recently demonstrated that high calcium delivery to the collecting duct reduces local Aquaporin-2 (AQP2) mediated water reabsorption under vasopressin action, thus limiting the maximal urinary concentration and reducing calcium saturation.	Water	117-122	arginine vasopressin	Homo sapiens	142-153
24700466-6	2014	We conclude that AQP-mediated water transport in macrophages constitutes a general danger signal required for NLRP3-related inflammation.	Water	30-35	NLR family pyrin domain containing 3	Homo sapiens	110-115
24630930-1	2014	Catalase is an antioxidant enzyme that catalyzes mainly the transformation of hydrogen peroxide into water and oxygen.	Water	101-106	catalase	Homo sapiens	0-8
24760830-2	2014	We report a 1.45-A resolution structure of yeast iso-1-cytochrome c with the Met80 heme ligand swung out of the heme crevice and replaced by a water molecule.	Water	143-148	cytochrome c, somatic	Homo sapiens	55-67
24832291-2	2014	To describe water molecules we used the SPC/E model.	Water	12-17	proline rich protein gene cluster	Homo sapiens	40-43
24844633-5	2014	Thermogravimetric studies show that the compound starts to decompose at 500 C. The crystal structure of the new compound is closely related to the previously described compound Cd4(SeO3)2Cl4(H2O).	Water	191-194	CD4 molecule	Homo sapiens	177-180
24655009-3	2014	Free residual chlorine in water was sensitively detected with a detection limit of 0.01 muM and had a very wide detection range of 0.02 to 10 muM.	Water	26-31	latexin	Homo sapiens	88-91
24655009-3	2014	Free residual chlorine in water was sensitively detected with a detection limit of 0.01 muM and had a very wide detection range of 0.02 to 10 muM.	Water	26-31	latexin	Homo sapiens	142-145
24525453-10	2014	In adjusted models, every log 10 increase in maternal drinking water arsenic exposure was estimated to increase CD8+ T cells by 7.4% (P = 0.0004) and decrease in CD4+ T cells by 9.2% (P = 0.0002).	Water	63-68	CD4 molecule	Homo sapiens	162-165
24664459-0	2014	Mouse organ coefficient and abnormal sperm rate analysis with exposure to tap water and source water in Nanjing reach of Yangtze River.	Water	78-83	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	74-77
24664459-7	2014	So liver coefficient might be more sensitive than other organ coefficients to reflect the exposure to tap water and source water, while abnormal sperm rate could not be used to reveal the exposure to them.	Water	106-111	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	102-105
24721109-9	2014	The log K values for [H2O-DPTC-Co] correlate reasonably well with those for H2OCbl(+); therefore, Co(III) displays a similar behavior toward these ligands irrespective of whether the equatorial ligand is a corrole or a corrin.	Water	22-25	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	98-104
24120524-3	2014	SCOPE OF REVIEW: The AQP1 structure determined by electron crystallography provided the first insights into the proton exclusion mechanism despite fast water permeation.	Water	152-157	aquaporin 1 (Colton blood group)	Homo sapiens	21-25
24189537-4	2014	Although some water permeability of AQP11 was demonstrated in liposomes and cultured cells, its permeability to glycerol is unknown.	Water	14-19	aquaporin 11	Homo sapiens	36-41
24360411-1	2014	In the present investigation, prepared N-ethyl-3-carbazolecarbaxaldehyde-3-thiosemicarbazone (ECCT) and employed for the simultaneous removal and determination of trace amounts of Cd(II) and Pb(II) from food and water samples.	Water	212-217	submaxillary gland androgen regulated protein 3B	Homo sapiens	191-197
26060766-11	2014	The relative standard deviation and limit of detection for water samples by introduced selective solid phase extraction were 4.8% and 0.9 mug L-1, and these data for urine samples were 4.5% and 1.60 mug L-1, respectively.	Water	59-64	immunoglobulin kappa variable 1-16	Homo sapiens	142-145
23837490-5	2014	Once recovery of the injected water begins, however, NO3 -N in the recovered water decreases quickly to &lt;3 mg/L (Eaton et al.	Water	77-82	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
24582549-4	2014	To do this, we administered MitoQ (500 microM) in the drinking water of SOD1(G93A) mice from a time when early symptoms of neurodegeneration become evident at 90 days of age until death.	Water	63-68	superoxide dismutase 1, soluble	Mus musculus	72-76
24583458-3	2014	This study assessed the potential of MPO activity inhibition by a water-soluble CORM, CORM-3.	Water	66-71	myeloperoxidase	Homo sapiens	37-40
24619662-1	2014	PURPOSE: Temsirolimus (TEM) is a novel, water-soluble mammalian target of rapamycin (mTOR) inhibitor that has shown activity against a wide range of cancers in preclinical models, but its efficacy against colorectal cancer (CRC) has not been fully explored.	Water	40-45	mechanistic target of rapamycin kinase	Homo sapiens	54-83
24619662-1	2014	PURPOSE: Temsirolimus (TEM) is a novel, water-soluble mammalian target of rapamycin (mTOR) inhibitor that has shown activity against a wide range of cancers in preclinical models, but its efficacy against colorectal cancer (CRC) has not been fully explored.	Water	40-45	mechanistic target of rapamycin kinase	Homo sapiens	85-89
24488947-2	2014	Pig blastocysts, on the other hand, show enhanced water and cryoprotectant permeability, which has been related to the transcriptional activation of aquaporin-3 (AQP3) channels at this stage of development.	Water	50-55	aquaporin 3	Sus scrofa	149-160
24813017-3	2014	The arsenic concentration in drinking water ranged from 12.8 to 132.2 mug l-1.	Water	38-43	immunoglobulin kappa variable 1-16	Homo sapiens	74-77
24813017-4	2014	The depth of source of drinking water (10-60 m) was also found with a mean of 36.12 +- 13.61 mug l-1 arsenic concentration.	Water	32-37	immunoglobulin kappa variable 1-16	Homo sapiens	97-100
24813017-10	2014	Correlation analysis also showed a significant positive correlation (r = 0.801, t = 5.66, P &lt; 0.05) between age of drinking water sources and their respective arsenic concentration (mug l-1).	Water	127-132	immunoglobulin kappa variable 1-16	Homo sapiens	189-192
24610798-0	2014	Aqueous copper-mediated living radical polymerisation of N-acryloylmorpholine, SET-LRP in water.	Water	90-95	LDL receptor related protein 1	Homo sapiens	83-86
24610798-1	2014	The polymerisation of N-acryloylmorpholine in water is reported utilising Cu(0)-mediated living radical polymerisation (SET-LRP).	Water	46-51	LDL receptor related protein 1	Homo sapiens	124-127
25831899-1	2014	In this work we carried out a comparative analysis of the two most popular water models-SPC/E and TIP4P and estimated the ability of using ones for insulin superfamily peptides-proinsulin and insulin-like growth factors (IGF1 and IGF2).	Water	75-80	proline rich protein gene cluster	Homo sapiens	88-91
24488947-2	2014	Pig blastocysts, on the other hand, show enhanced water and cryoprotectant permeability, which has been related to the transcriptional activation of aquaporin-3 (AQP3) channels at this stage of development.	Water	50-55	aquaporin 3	Sus scrofa	162-166
24593923-3	2014	Although not statistically significant after correcting for multiple testing, nine SNPs in APOE, AS3MT, PNP, and TNF genes had a nominally statistically significant interaction with well-water arsenic in cIMT.	Water	187-192	apolipoprotein E	Homo sapiens	91-95
23397434-3	2014	This review focuses on the study of molecular complexes, design of which is inspired by the components of natural photosynthesis, and covers research from early triad reaction centers developed by the group of Gust, Moore, and Moore to recent photoelectrochemical systems capable of using light to convert water to oxygen and hydrogen.	Water	306-311	GUST	Homo sapiens	210-214
24456050-12	2014	In multiple linear regression analysis, the variables associated with hydration status were male sex, extracellular water/total body water, and extracellular water/intracellular water (greater overhydration), while serum albumin levels had a negative association with overhydration.	Water	116-121	albumin	Homo sapiens	221-228
24456050-12	2014	In multiple linear regression analysis, the variables associated with hydration status were male sex, extracellular water/total body water, and extracellular water/intracellular water (greater overhydration), while serum albumin levels had a negative association with overhydration.	Water	133-138	albumin	Homo sapiens	221-228
24456050-12	2014	In multiple linear regression analysis, the variables associated with hydration status were male sex, extracellular water/total body water, and extracellular water/intracellular water (greater overhydration), while serum albumin levels had a negative association with overhydration.	Water	133-138	albumin	Homo sapiens	221-228
24456050-12	2014	In multiple linear regression analysis, the variables associated with hydration status were male sex, extracellular water/total body water, and extracellular water/intracellular water (greater overhydration), while serum albumin levels had a negative association with overhydration.	Water	133-138	albumin	Homo sapiens	221-228
24593923-3	2014	Although not statistically significant after correcting for multiple testing, nine SNPs in APOE, AS3MT, PNP, and TNF genes had a nominally statistically significant interaction with well-water arsenic in cIMT.	Water	187-192	tumor necrosis factor	Homo sapiens	113-116
24457936-1	2014	Vibrational spectroscopy enables subtle details of the molecular structure of minyulite KAl2(OH,F)(PO4)2 4(H2O).	Water	107-110	fibroblast growth factor receptor 1	Homo sapiens	88-92
24637450-8	2014	Bromides, ammonium and phosphate were the main species in water sorption samples for PCB pyrolysis exhaust.	Water	58-63	pyruvate carboxylase	Homo sapiens	85-88
24964631-0	2014	[Expression and significance of ERalpha mRNA of residents exposed to arsenic via drinking water].	Water	90-95	estrogen receptor 1	Homo sapiens	32-39
24964631-6	2014	Tp-Te interval prolonged with increasing of water As (r = 0.199, P = 0.023), as well prolonged with increasing of ERbeta mRNA expression (r = 0.205, P = 0.019).	Water	44-49	transmembrane phosphatase with tensin homology	Homo sapiens	0-5
24584068-3	2014	Batch and column experimental results revealed that the nanoparticle treatment greatly reduced water-leachable As(V) and the leachability of As(V) remaining in the soil per TCLP (Toxicity Characteristic Leaching Procedure) analysis.	Water	95-100	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	111-116
24584068-4	2014	Column tests showed that water-leachable As(V) from the As(V)-laden soil containing 31.45 mg/kg was reduced by ~93% and the TCLP leachability by &gt;83% when the soil was treated with 34 pore volumes of a 0.1g-Fe/L of the nanoparticle suspension.	Water	25-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
24584068-4	2014	Column tests showed that water-leachable As(V) from the As(V)-laden soil containing 31.45 mg/kg was reduced by ~93% and the TCLP leachability by &gt;83% when the soil was treated with 34 pore volumes of a 0.1g-Fe/L of the nanoparticle suspension.	Water	25-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	56-61
24763386-1	2014	Growth hormone (GH) may stimulate water loss during exercise by activating sweating.	Water	34-39	growth hormone 1	Homo sapiens	0-14
24763386-1	2014	Growth hormone (GH) may stimulate water loss during exercise by activating sweating.	Water	34-39	growth hormone 1	Homo sapiens	16-18
24657265-11	2014	The full enlightenment of this particular relation between CFTR and AQP4 may point towards possible therapeutic targets to counteract male subfertility/infertility in men with Cystic Fibrosis and mutations in CFTR gene, which are known to impair spermatogenesis due to defective water transport.	Water	279-284	CF transmembrane conductance regulator	Homo sapiens	59-63
24779061-3	2014	This modification affects the performance of SA1 remarkably in terms of its sensitivity, water compatibility and efficiency as well as its mechanistic aspect.	Water	89-94	stromal antigen 1	Homo sapiens	45-48
24657265-11	2014	The full enlightenment of this particular relation between CFTR and AQP4 may point towards possible therapeutic targets to counteract male subfertility/infertility in men with Cystic Fibrosis and mutations in CFTR gene, which are known to impair spermatogenesis due to defective water transport.	Water	279-284	CF transmembrane conductance regulator	Homo sapiens	209-213
24532188-2	2014	Through the activation of Me2 PhSiBpin in water at room temperature and open atmosphere, vinylsilanes conjugated to carbonyl groups are synthesized in high yield.	Water	42-47	malic enzyme 2	Homo sapiens	26-29
24583185-5	2014	There was a significant interaction between insulin sensitivity (sensitive vs resistant) and condition (water vs glucose).	Water	104-109	insulin	Homo sapiens	44-51
24684235-0	2014	Rapid ligations with equimolar reactants in water with the potassium acyltrifluoroborate (KAT) amide formation.	Water	44-49	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	90-93
24966924-4	2014	RESULTS: Immunocytochemistry, RT-PCR, and western blot analyses showed more pronounced Ngb expression in the hemin and exogenous Ngb joint operation group than in the hemin or exogenous Ngb individual treatment groups, thus producing significant differences in brain water content and infarct volume (p&lt;0.05).	Water	267-272	neuroglobin	Rattus norvegicus	129-132
24966924-4	2014	RESULTS: Immunocytochemistry, RT-PCR, and western blot analyses showed more pronounced Ngb expression in the hemin and exogenous Ngb joint operation group than in the hemin or exogenous Ngb individual treatment groups, thus producing significant differences in brain water content and infarct volume (p&lt;0.05).	Water	267-272	neuroglobin	Rattus norvegicus	129-132
24641444-0	2014	Sensitivity of water dynamics to biologically significant surfaces of monomeric insulin: role of topology and electrostatic interactions.	Water	15-20	insulin	Homo sapiens	80-87
24641444-3	2014	In order to characterize the structural and dynamical behavior of interfacial water molecules near these two surfaces (DFS and HFS), we performed atomistic molecular dynamics simulations of insulin with explicit water.	Water	78-83	insulin	Homo sapiens	190-197
24620851-7	2014	The distance between the sodium ions and micelle also depends on the number of waters binding to sodium ions in the presence of surfactant head groups, which depends on both the sodium ion and water models, and for the same sodium model increases as the water model is changed in the order: TIP4P, SPC/E, SPC, and TIP3P.	Water	79-84	proline rich protein gene cluster	Homo sapiens	298-301
24620851-7	2014	The distance between the sodium ions and micelle also depends on the number of waters binding to sodium ions in the presence of surfactant head groups, which depends on both the sodium ion and water models, and for the same sodium model increases as the water model is changed in the order: TIP4P, SPC/E, SPC, and TIP3P.	Water	79-84	proline rich protein gene cluster	Homo sapiens	305-308
24712798-1	2014	High-density amorphous water is simulated by use of isothermal-isobaric molecular dynamics at a pressure of 0.3 GPa making use of several water models (SPC/E, TIP3P, TIP4P variants, and TIP5P).	Water	23-28	proline rich protein gene cluster	Homo sapiens	152-155
24620851-7	2014	The distance between the sodium ions and micelle also depends on the number of waters binding to sodium ions in the presence of surfactant head groups, which depends on both the sodium ion and water models, and for the same sodium model increases as the water model is changed in the order: TIP4P, SPC/E, SPC, and TIP3P.	Water	193-198	proline rich protein gene cluster	Homo sapiens	298-301
24620851-7	2014	The distance between the sodium ions and micelle also depends on the number of waters binding to sodium ions in the presence of surfactant head groups, which depends on both the sodium ion and water models, and for the same sodium model increases as the water model is changed in the order: TIP4P, SPC/E, SPC, and TIP3P.	Water	193-198	proline rich protein gene cluster	Homo sapiens	305-308
24481236-2	2014	Closo-, nido- and iodo-carborane conjugates were prepared and screened in vitro where the water soluble iodinated cluster had the highest affinity with an IC50 value (73.2 nM) that was comparable to a known PSMA inhibitor 2-(phosphonomethyl)-pentanedioic acid (PMPA, 63.9 nM).	Water	90-95	folate hydrolase 1	Homo sapiens	207-211
24635104-2	2014	The ligand readily accommodates Co(II) bearing two axial chlorides, and the resulting complex is reasonably soluble in water.	Water	119-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
24562186-0	2014	Outer Co(II) ions in Co-ZIF-67 reversibly adsorb oxygen from both gas phase and liquid water.	Water	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
24562186-1	2014	Outer Co(II) species in Co-ZIF-67 coordinate molecular oxygen both from the gas phase and liquid water, through an adsorption process (presumably yielding in both cases surface superoxo species), respectively weak and reversible (gas phase), and strong and irreversible (liquid); in the latter case desorption is however brought about by illumination with solar light comprising the UV component.	Water	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
24491850-0	2014	Reply to the comments on "a study of the phosphate mineral kapundaite NaCa(Fe(3+))4(PO4)4(OH)3 5(H2O) using SEM/EDX and vibrational spectroscopic methods" by Frost et al.	Water	97-100	nascent polypeptide associated complex subunit alpha	Homo sapiens	70-74
24388955-5	2014	Because some snail species are obligate intermediate hosts of schistosome parasites, removing snails may reduce parasitic larvae in the water, reducing re-infection risk.	Water	136-141	snail family transcriptional repressor 1	Homo sapiens	13-18
24477233-1	2014	The sodium-coupled glucose transporter-1 (SGLT1)-based oral rehydration solution (ORS) used in the management of acute diarrhea does not substantially reduce stool output, despite the fact that glucose stimulates the absorption of sodium and water.	Water	242-247	solute carrier family 5 member 1	Homo sapiens	42-47
24363090-0	2014	A synergic role of caspase-6 and caspase-3 in Tau truncation at D421 induced by H2O 2.	Water	80-83	caspase 3	Homo sapiens	33-42
24824702-0	2014	Effect of prolactin on the water-salt balance in rat females in the model of cholestasis of pregnancy.	Water	27-32	prolactin	Rattus norvegicus	10-19
24824702-1	2014	We studied the possibility of prolactin involvement in the regulation of water-salt metabolism in female rats in the model of cholestasis of pregnancy.	Water	73-78	prolactin	Rattus norvegicus	30-39
24588923-1	2014	Changes in water metabolism and regulation of vasopressin (AVP) or antidiuretic hormone (ADH) are common complications of pituitary surgery.	Water	11-16	arginine vasopressin	Homo sapiens	67-87
24588923-1	2014	Changes in water metabolism and regulation of vasopressin (AVP) or antidiuretic hormone (ADH) are common complications of pituitary surgery.	Water	11-16	arginine vasopressin	Homo sapiens	89-92
24122228-0	2014	Expression of aquaporin-4 water channels in the digestive tract of the guinea pig.	Water	26-31	aquaporin-4	Cavia porcellus	14-25
24481335-9	2014	Enzyme substrate analysis revealed that TGase2-mediated protein modification promoted protein aggregation concurrently with decreasing water solubility.	Water	135-140	transglutaminase 2	Homo sapiens	40-46
23640792-6	2014	Despite significant ALP surface activity and lower water contact for angles ALP-containing surface modifications, only marginal effects on early cell behavior (i.e., cell spreading) and osteogenic differentiation (i.e., proliferation, differentiation and mineralization) were observed in comparison to uncoated titanium.	Water	51-56	alkaline phosphatase, placental	Homo sapiens	76-79
24122228-1	2014	Expression of the aquaporin-4 (AQP4) water channel was systematically studied in the digestive tract of the guinea pig using Western blot and immunofluorescence techniques.	Water	37-42	aquaporin-4	Cavia porcellus	18-29
24122228-1	2014	Expression of the aquaporin-4 (AQP4) water channel was systematically studied in the digestive tract of the guinea pig using Western blot and immunofluorescence techniques.	Water	37-42	aquaporin-4	Cavia porcellus	31-35
24122228-7	2014	It has been speculated that AQP4 may be involved in water transport in the gastrointestinal tract.	Water	52-57	aquaporin-4	Cavia porcellus	28-32
24729658-7	2014	Our experiments link the two imperatives for TIM-catalyzed deprotonation of carbon by providing evidence that the phosphodianion binding energy is utilized to drive an enzyme conformational change, which results in a reduction in the thermodynamic barrier to deprotonation of the carbon acid substrate at TIM compared with the barrier for deprotonation in water.	Water	356-361	triosephosphate isomerase 1	Homo sapiens	45-48
24734757-2	2014	Two water-soluble proteins, bovine serum albumin (BSA) and egg white lysozyme (LYS), were employed in this work.	Water	4-9	albumin	Homo sapiens	35-54
24320144-0	2014	Distinct signaling pathways leading to the induction of human beta-defensin 2 by stimulating an electrolyticaly-generated acid functional water and double strand RNA in oral epithelial cells.	Water	138-143	defensin beta 4A	Homo sapiens	62-77
24492838-7	2014	Reciprocally, slow intragastric infusions of water that lower osmolality reduced basal ERK phosphorylation.	Water	45-50	Eph receptor B1	Rattus norvegicus	87-90
24729658-7	2014	Our experiments link the two imperatives for TIM-catalyzed deprotonation of carbon by providing evidence that the phosphodianion binding energy is utilized to drive an enzyme conformational change, which results in a reduction in the thermodynamic barrier to deprotonation of the carbon acid substrate at TIM compared with the barrier for deprotonation in water.	Water	356-361	triosephosphate isomerase 1	Homo sapiens	305-308
24320144-3	2014	We also examined the hBD-2-inducible activity of acid-electrolyzed functional water (FW).	Water	78-83	defensin beta 4A	Homo sapiens	21-26
23802191-4	2014	Several lines of evidence have demonstrated that the water channel aquaporin-1 (AQP1) corresponds to the ultrasmall pore located in endothelial cells.	Water	53-58	aquaporin 1 (Colton blood group)	Homo sapiens	80-84
23802191-6	2014	Haploinsufficiency in AQP1 is also reflected by a significant attenuation of water transport.	Water	77-82	aquaporin 1 (Colton blood group)	Homo sapiens	22-26
23802191-7	2014	Conversely, studies in a rat model and in PD patients have shown that the induction of AQP1 in peritoneal capillaries by corticosteroids is reflected by increased water transport and ultrafiltration, without affecting the osmotic gradient and small-solute transport.	Water	163-168	aquaporin 1 (Colton blood group)	Homo sapiens	87-91
23802191-8	2014	Recent data have demonstrated that a novel agonist of AQP1, predicted to stabilize the open-state conformation of the channel, modulates water transport and improves ultrafiltration.	Water	137-142	aquaporin 1 (Colton blood group)	Homo sapiens	54-58
24760529-3	2014	Our group demonstrated that AC6, but not AC3, is involved in regulating CD Na and water transport.	Water	82-87	adenylate cyclase 6	Mus musculus	28-31
24613483-10	2014	In cystic fibrosis, the central cAMP-dependent regulation of ion and water transport via functional CFTR is lost.	Water	69-74	CF transmembrane conductance regulator	Homo sapiens	100-104
24607106-2	2014	The water-compatible molecularly imprinted polymers (MIPs) were prepared using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, chloroform as a porogen and insulin as a template molecule.	Water	4-9	insulin	Homo sapiens	199-206
23836416-3	2014	Water-soluble conjugated polyfluorene derivative poly(9,9-bis(6-sulphate hexyl) fluorene-alt-1,4-phenylene) sodium salt (P1) binds Fe(3+) heme proteins selectively in cerebrospinal fluid (CSF), including ferritin in the Abeta fibrils and diminishes their accumulation.	Water	0-5	amyloid beta precursor protein	Homo sapiens	220-225
24729151-3	2014	Changes in AVP concentration have the greatest relative effects on urine volume when AVP levels are low; therefore small changes can have a large effect on renal water excretion.	Water	162-167	arginine vasopressin	Homo sapiens	11-14
24729151-4	2014	AVP is the major regulator of water excretion by the kidneys, and AVP levels have been shown to affect nocturnal voiding.	Water	30-35	arginine vasopressin	Homo sapiens	0-3
30534332-2	2014	Tolvaptan, a vasopressin V2-receptor antagonist, has been reported to be effective in treating HF due to its potent effects of water diuresis and is expected to improve fluid retention without adversely affecting renal function.	Water	127-132	arginine vasopressin receptor 2	Homo sapiens	13-36
24670377-10	2014	Assimilation was the primary fate for NO3(-) under typical stormwater concentrations (~1-2 mg N/L), contributing an average 89-99% of 15NO3(-) processing in biofilter columns containing the most effective plant species, while only 0-3% was denitrified and 0-8% remained in the pore water.	Water	64-69	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
24299984-0	2014	Synthesis, characterization and the interaction of some new water-soluble metal Schiff base complexes with human serum albumin.	Water	60-65	albumin	Homo sapiens	113-126
24299984-4	2014	The mechanism of binding of Na2[M(L)(H2O)n] with human serum albumin (HSA) was studied by fluorescence spectroscopic technique.	Water	37-40	albumin	Homo sapiens	55-68
24615977-3	2014	The released paramagnetic species causes an increase of the longitudinal water proton relaxation rate proportional to the number of PLA2 bound to the cell outer surface.	Water	73-78	phospholipase A2 group IB	Homo sapiens	132-136
24655207-0	2014	Effect of ethanol-water mixture on the structure and dynamics of lysozyme: a fluorescence correlation spectroscopy study.	Water	18-23	lysozyme	Homo sapiens	65-73
24317266-0	2014	A study of the phosphate mineral kapundaite NaCa(Fe3+)4(PO4)4(OH)3 5(H2O) using SEM/EDX and vibrational spectroscopic methods.	Water	69-72	nascent polypeptide associated complex subunit alpha	Homo sapiens	44-48
24655207-1	2014	Effect of ethanol-water mixture on the hydrodynamic radius (r(H)) and conformational dynamics of lysozyme has been studied by circular dichroism, emission spectra, and fluorescence correlation spectroscopy.	Water	18-23	lysozyme	Homo sapiens	97-105
24649826-8	2014	RESULTS: For equilibration with CPA, our algorithm predicts an optimal first step consisting of exposure to a solution containing only water and CPA.	Water	135-140	carboxypeptidase A1	Homo sapiens	32-35
24452376-1	2014	Regulated urine concentration takes place in the renal collecting duct upon arginine vasopressin (AVP) stimulation, where subapical vesicles containing aquaporin-2 (AQP2) are inserted into the apical membrane instantly increasing water reabsorption and urine concentration.	Water	230-235	arginine vasopressin	Homo sapiens	85-96
24591641-4	2014	From the structure, which includes the catalytic water, and mass spectrometric analysis of enzymatic hydrolysis products of Pro-Gly-Pro, it could be inferred that LTA4 hydrolase cleaves at the N terminus of the palindromic tripeptide.	Water	49-54	leukotriene A4 hydrolase	Homo sapiens	163-177
24571078-6	2014	In order to mimic macroscopic systems at room temperature, we perform inhomogeneous MC simulations of model corundum surface in contact with the water phase modeled by SPC/E model.	Water	145-150	proline rich protein gene cluster	Homo sapiens	168-171
24608897-3	2014	Here, we found evidence that bioluminescent sharks instead emit a constant light output and move up and down in the water column to remain cryptic at iso-luminance depth.	Water	116-121	cripto, FRL-1, cryptic family 1	Homo sapiens	139-146
24803856-7	2014	Condensed phase simulation of mDC water is performed and shown to produce O-O radial distribution functions similar to TIP4P-EW.	Water	34-39	chemokine (C-C motif) ligand 22	Mus musculus	30-33
24457981-0	2014	Water-soluble polymers, solid polymer membranes, and coated fibres as smart sensory materials for the naked eye detection and quantification of TNT in aqueous media.	Water	0-5	chromosome 16 open reading frame 82	Homo sapiens	144-147
24425867-4	2014	These structures reveal that the oxicams bind to the active site of COX-2 using a binding pose not seen with other NSAIDs through two highly coordinated water molecules.	Water	153-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
24580394-3	2014	The review is presented on the infusion of sterile water (hypotonic fluid) to lower serum sodium level in those circumstances when enteral supplementation of water is not possible, such as in postoperative patients or when other isotonic fluids (such as 5% dextrose in water infusion) are less than ideal-for example, hyperglycaemic patients on an insulin infusion.	Water	51-56	insulin	Homo sapiens	348-355
24412302-8	2014	Post-docking intramolecular hydrogen bonding analysis shows water molecule mediated hydrogen bonding for N-terminal maltase glucoamylase and N-terminal sucrase isomaltase.	Water	60-65	maltase-glucoamylase 2	Rattus norvegicus	116-136
24458158-1	2014	PURPOSE: Lens fiber cell membranes contain aquaporin-0 (AQP0), which constitutes approximately 50% of the total fiber cell membrane proteins and has a dual function as a water channel protein and an adhesion molecule.	Water	170-175	major intrinsic protein of lens fiber	Mus musculus	43-54
24458158-1	2014	PURPOSE: Lens fiber cell membranes contain aquaporin-0 (AQP0), which constitutes approximately 50% of the total fiber cell membrane proteins and has a dual function as a water channel protein and an adhesion molecule.	Water	170-175	major intrinsic protein of lens fiber	Mus musculus	56-60
24598918-1	2014	Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water.	Water	144-149	cystathionine beta-synthase	Homo sapiens	0-27
24598918-1	2014	Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water.	Water	144-149	cystathionine beta-synthase	Homo sapiens	29-32
23804246-3	2014	Here, explicit solvent molecular dynamics (MD) simulations of two bromodomains (BAZ2B and CREBBP) are used to analyze the water molecules that seem to be conserved at the bottom of the acetyl-lysine binding site in most crystal structures of bromodomains.	Water	122-127	CREB binding protein	Homo sapiens	90-96
24247549-11	2014	Tap water and industrial wastewater were selected as real-world water samples to assess the applicability of the method.	Water	4-9	SEC14 like lipid binding 2	Homo sapiens	0-3
24770738-2	2014	Intracellular reorganization of transepithelial barrier for osmotic water transport depended on the capacity of rats to the synthesis of endogenous vasopressin.	Water	68-73	arginine vasopressin	Rattus norvegicus	148-159
24620844-4	2014	Interatrial and epicardial fat was analyzed with a Dark-blood DIR-prepared Fat-Water-separated sequence in the horizontal longitudinal axis.	Water	79-84	arginine vasopressin receptor 2	Homo sapiens	62-65
24508134-1	2014	The design, synthesis and biological evaluation of novel triazolyl p38alpha MAPK inhibitors with improved water solubility for formulation in cationic liposomes (SAINT-O-Somes) targeted at diseased endothelial cells is described.	Water	106-111	mitogen-activated protein kinase 14	Homo sapiens	67-75
24508134-2	2014	Water-solubilizing groups were introduced via a "click" reaction of functional azides with 2-alkynyl imidazoles and isosteric oxazoles to generate two small libraries of 1,4-disubstituted 1,2,3-triazolyl p38alpha MAPK inhibitors.	Water	0-5	mitogen-activated protein kinase 14	Homo sapiens	204-207
25051748-8	2014	In the experimental study of the effect of water with different content of LCA on heart rate and cardiac output of the frog it was found that the optimum level of structuredness of water is within the range of 5.06 +/- 0.09% (in water "Lekor") - 6.9 +/- 0.23% (tap water treated with Bioptron).	Water	181-186	nuclear RNA export factor 1	Rattus norvegicus	261-264
24462958-7	2014	Water solubility was increased 22.75-, 15.15-, and 12.86-fold for isorhamnetin, kaempferol, and quercetin, respectively, in the presence of 20mg/mL IP6.	Water	0-5	DnaJ heat shock protein family (Hsp40) member C14	Mus musculus	145-151
25051748-8	2014	In the experimental study of the effect of water with different content of LCA on heart rate and cardiac output of the frog it was found that the optimum level of structuredness of water is within the range of 5.06 +/- 0.09% (in water "Lekor") - 6.9 +/- 0.23% (tap water treated with Bioptron).	Water	181-186	nuclear RNA export factor 1	Rattus norvegicus	261-264
25051748-8	2014	In the experimental study of the effect of water with different content of LCA on heart rate and cardiac output of the frog it was found that the optimum level of structuredness of water is within the range of 5.06 +/- 0.09% (in water "Lekor") - 6.9 +/- 0.23% (tap water treated with Bioptron).	Water	181-186	nuclear RNA export factor 1	Rattus norvegicus	261-264
24485635-4	2014	Intraatrial and epicardial fat was analyzed with a Dark-blood DIR-prepared Fat-Water-separated sequence in the horizontal longitudinal axis.	Water	79-84	arginine vasopressin receptor 2	Homo sapiens	62-65
23863802-3	2014	Increased CYP3A5 activity could cause sodium and water retention by affecting the metabolism of cortisol in the kidneys.	Water	49-54	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	10-16
24606257-5	2014	An experimental investigation of the CRS was conducted in the shock pressure field produced in water using an optical hydrophone (FOPH2000, RP Acoustics, Germany).	Water	95-100	twist family bHLH transcription factor 1	Homo sapiens	37-40
24407669-3	2014	The peptide and PEG segments were hierarchically segregated after the peptide-PEG conjugate was adsorbed on the substrate, and the peptide segment transitioned from a random-coil to a beta-sheet conformation specifically at the solid/water interface.	Water	234-239	amyloid beta precursor protein	Homo sapiens	182-188
24039193-1	2014	SCOPE: The cathelicidin antimicrobial peptide (CAMP) gene is induced by 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2 D3), lithocholic acid, curcumin, nicotinamide, and butyrate.	Water	112-117	cathelicidin antimicrobial peptide	Homo sapiens	11-45
24326134-4	2014	In this way, two Co(III) complexes [Co(bhnq)(L1)]BF4 H2O (1) and [Co(bhnq)(L2)]BF4 H2O (2) (L1=N,N"-bis(pyridin-2-ylmethyl)ethylenediamine and L2=N,N"-dimethyl-N,N"-bis(pyridin-2-ylmethyl)ethylenediamine) were synthesized and fully characterized.	Water	53-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	17-24
24039193-1	2014	SCOPE: The cathelicidin antimicrobial peptide (CAMP) gene is induced by 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2 D3), lithocholic acid, curcumin, nicotinamide, and butyrate.	Water	112-117	cathelicidin antimicrobial peptide	Homo sapiens	47-51
24484680-6	2014	PA remained associated with the rate of change in IL-6 even after controlling for extracellular water and fat mass.	Water	96-101	interleukin 6	Homo sapiens	50-54
24984482-5	2014	The fractal dimension (D) of mechanical stability in soil aggregates followed the order of CD&gt;HD&gt;ST&gt;RGL&gt;CSL&gt;GC and the water stability was in the order of GC&gt;CSL&gt;RGL&gt;HD&gt; CD&gt;ST.	Water	134-139	chorionic somatomammotropin hormone like 1	Homo sapiens	176-179
24468351-4	2014	Assays performed by BAmicroE(AC2)-microLD/LVI-GC-MS(SIM) on 25 mL of ultrapure water samples spiked at the 1.0 mug/L level, yielded recoveries ranging from 73.8+-8.8% (trans-PERM) to 96.4+-9.9% (DEET), under optimised experimental conditions.	Water	79-84	adenylate cyclase 2	Homo sapiens	29-32
24342025-7	2014	Of note, ever use of well water before the onset of PD symptoms had an impact on the occurrence of PD through interactions with BST1 rs11724635 AC (OR = 1.453, p = 0.024) and CC (OR = 1.623, p = 0.008).	Water	26-31	bone marrow stromal cell antigen 1	Homo sapiens	128-132
24342025-8	2014	Our results show that the BST1 rs11724635 polymorphism alone is not associated with the development of PD, but it can interact with well water drinking to increase the risk of PD in this Taiwanese population.	Water	137-142	bone marrow stromal cell antigen 1	Homo sapiens	26-30
25007586-1	2014	Anthocyanins are a ubiquitous group of water-soluble plant pigments of the flavonoid family, with anticancer property through HER-2 signaling pathway.	Water	39-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	126-131
24468357-4	2014	The reduction of water content in the carrier gas to 2.2-2.4 g m(-3) and to 1.8-2.0 g m(-3) for the short and long desolvation unit, respectively, was achieved at an electrospray flow rate of 1000 nL min(-1).	Water	17-22	CD59 molecule (CD59 blood group)	Homo sapiens	200-206
24395502-4	2014	RESULTS: The delta(2)H and delta(18)O values of this reference water are -150.2 +- 0.5% and -19.80 +- 0.02%, respectively, relative to VSMOW, on scales normalized such that the delta(2)H and delta(18)O values of SLAP reference water are, respectively, -428 and -55.5%.	Water	63-68	Src like adaptor	Homo sapiens	212-216
24573329-3	2014	We have studied the effect of surface curvature on the association of two proteins, alpha-lactalbumin (alpha-LA) and beta-lactoglobulin (beta-LG), which perform their function at the oil-water interface in milk emulsions.	Water	187-192	lactalbumin alpha	Homo sapiens	84-101
24568581-7	2014	A beta contact"s potential contribution to protein binding is also supposed to be inversely proportional to its ASA to follow the water exclusion hypothesis of binding hot spots.	Water	130-135	amyloid beta precursor protein	Homo sapiens	0-6
24573329-3	2014	We have studied the effect of surface curvature on the association of two proteins, alpha-lactalbumin (alpha-LA) and beta-lactoglobulin (beta-LG), which perform their function at the oil-water interface in milk emulsions.	Water	187-192	lactalbumin alpha	Homo sapiens	103-111
24574031-1	2014	The reaction of fac-[M(III)F3(Me3tacn)] x H2O with Gd(NO3)3 5H2O affords a series of fluoride-bridged, trigonal bipyramidal {Gd(III)3M(III)2} (M = Cr (1), Fe (2), Ga (3)) complexes without signs of concomitant GdF3 formation, thereby demonstrating the applicability even of labile fluoride-complexes as precursors for 3d-4f systems.	Water	42-45	FA complementation group C	Homo sapiens	16-19
24460097-5	2014	Lyman-alpha photolysis of H2O:HCONH2 mixed ices increases OCN(-) and CO production, suggesting a catalytic role of H2O.	Water	26-29	bone gamma-carboxyglutamate protein	Homo sapiens	58-61
24402189-1	2014	Efficient photocatalytic hydrogen evolution is obtained from 1 M phosphate buffer at pH 7 in the presence of a Ru(bpy)3(2+) sensitizer, an ascorbic acid sacrificial donor, and a water-soluble Co(II) porphyrin catalyst.	Water	178-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-198
24460097-5	2014	Lyman-alpha photolysis of H2O:HCONH2 mixed ices increases OCN(-) and CO production, suggesting a catalytic role of H2O.	Water	115-118	bone gamma-carboxyglutamate protein	Homo sapiens	58-61
24506162-4	2014	The CO2 diffusion coefficients obtained in pure water and water/ethanol mixtures composed of TIP5P water molecules were always found to exceed the coefficients obtained in mixtures composed of SPC/E water molecules, a trend that was attributed to a larger propensity of SPC/E water molecules to form hydrogen bonds.	Water	58-63	proline rich protein gene cluster	Homo sapiens	270-273
24381181-9	2014	Results from real-time PCR suggested that the mRNA expression of the hypocalcemic hormone stanniocalcin (stc-1) remained elevated in the CaSR morphants following acclimation to low-Ca(2+) water.	Water	188-193	stanniocalcin 1	Danio rerio	105-110
24506162-4	2014	The CO2 diffusion coefficients obtained in pure water and water/ethanol mixtures composed of TIP5P water molecules were always found to exceed the coefficients obtained in mixtures composed of SPC/E water molecules, a trend that was attributed to a larger propensity of SPC/E water molecules to form hydrogen bonds.	Water	58-63	proline rich protein gene cluster	Homo sapiens	270-273
24506162-4	2014	The CO2 diffusion coefficients obtained in pure water and water/ethanol mixtures composed of TIP5P water molecules were always found to exceed the coefficients obtained in mixtures composed of SPC/E water molecules, a trend that was attributed to a larger propensity of SPC/E water molecules to form hydrogen bonds.	Water	58-63	proline rich protein gene cluster	Homo sapiens	270-273
24506162-4	2014	The CO2 diffusion coefficients obtained in pure water and water/ethanol mixtures composed of TIP5P water molecules were always found to exceed the coefficients obtained in mixtures composed of SPC/E water molecules, a trend that was attributed to a larger propensity of SPC/E water molecules to form hydrogen bonds.	Water	58-63	proline rich protein gene cluster	Homo sapiens	270-273
24506162-5	2014	Despite the fact that the SPC/E model is more accurate than the TIP5P model to compute water self-diffusion and CO2 diffusion in pure water, the diffusion coefficients of CO2 molecules in the water/ethanol mixture are in much better agreement with the experimental values of 1.4 - 1.5 x 10(-9) m(2)/s obtained for Champagne wines when the TIP5P model is employed.	Water	87-92	proline rich protein gene cluster	Homo sapiens	26-29
24506162-5	2014	Despite the fact that the SPC/E model is more accurate than the TIP5P model to compute water self-diffusion and CO2 diffusion in pure water, the diffusion coefficients of CO2 molecules in the water/ethanol mixture are in much better agreement with the experimental values of 1.4 - 1.5 x 10(-9) m(2)/s obtained for Champagne wines when the TIP5P model is employed.	Water	134-139	proline rich protein gene cluster	Homo sapiens	26-29
24506162-5	2014	Despite the fact that the SPC/E model is more accurate than the TIP5P model to compute water self-diffusion and CO2 diffusion in pure water, the diffusion coefficients of CO2 molecules in the water/ethanol mixture are in much better agreement with the experimental values of 1.4 - 1.5 x 10(-9) m(2)/s obtained for Champagne wines when the TIP5P model is employed.	Water	134-139	proline rich protein gene cluster	Homo sapiens	26-29
24506162-6	2014	This difference was deemed to rely on the larger propensity of SPC/E water molecules to maintain the hydrogen-bonded network between water molecules and form new hydrogen bonds with ethanol, although statistical issues cannot be completely excluded.	Water	69-74	proline rich protein gene cluster	Homo sapiens	63-66
24506162-6	2014	This difference was deemed to rely on the larger propensity of SPC/E water molecules to maintain the hydrogen-bonded network between water molecules and form new hydrogen bonds with ethanol, although statistical issues cannot be completely excluded.	Water	133-138	proline rich protein gene cluster	Homo sapiens	63-66
24509355-6	2014	The renin-angiotensin-system, which is one of the most important elements of the regulation of blood pressure and water-salt metabolism, plays an important role in the development of diabetic nephropathy.	Water	114-119	renin	Homo sapiens	4-9
25309098-8	2014	Our results indicate that NIR wavelengths at 1460-nm and 1550-nm, coincident with higher water absorption yield the highest contrast between dental composites and tooth structure.	Water	89-94	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	26-29
24459103-3	2014	To improve this situation, BODIPY-amidothiourea dyes with varying hydrogen-bond donating strengths were developed, the most H-acidic of which (1 c) could detect F(-) from an inorganic source (NaF) in 50 % aqueous solution (DMSO/water 1:1, v/v) with 0.01 ppm sensitivity through selective fluorescence quenching by a photoinduced electron-transfer (PET) process.	Water	228-233	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
24342087-7	2014	As small SMP molecules are more difficult to remove by conventional water treatment processes, more efforts are needed to control wastewater-derived DBP problem in water resource management.	Water	68-73	D-box binding PAR bZIP transcription factor	Homo sapiens	149-152
24064475-7	2014	With sulfadimethoxine and thrombin as model analytes, we found that water resuspended AuNPs can significantly increase the sensitivity by more than 10-fold for AuNPs based fluorescence quenching aptasensor.	Water	68-73	coagulation factor II, thrombin	Homo sapiens	26-34
24507254-1	2014	A water-insoluble beta-(1   3)-D-glucan (GLPs) with few branches at C-6 and C-2 positions was extracted from the fruit body of Ganoderma Lucidum by 1M NaOH at 40  C. By the striking inhibition of NO and TNF-alpha production, GLPs showed significant anti-inflammation activity against LPS induced Raw 264.7 cells.	Water	2-7	tumor necrosis factor	Mus musculus	203-212
24531218-1	2014	Danshensu (DSU) and salvianolic acid B (SAB) are the primary water-soluble compounds of Salvia miltiorrhiza Bunge (Lamiaceae).	Water	61-66	SH3 domain binding protein 5	Homo sapiens	40-43
24445127-2	2014	A GAMM with time, geographical zone, periodicity and the organic carbon - water partition coefficient as covariates explained 49% of the variability in the log transformed PCB sediment concentrations.	Water	74-79	pyruvate carboxylase	Homo sapiens	172-175
24305472-9	2014	We also provide ancillary in vitro data in rat inner-medullary-collecting-duct suspensions showing that tolvaptan can block vasopressin"s effects on phosphorylation of the water channel AQP2 in vitro.	Water	172-177	arginine vasopressin	Rattus norvegicus	124-135
23771506-3	2014	An 8-month-old Bmi-1(+/-) brains demonstrated mild oxidative stress, revealed by significant increases in hydroxy radical and nitrotyrosine, and nonsignificant increases in reactive oxygen species and malonaldehyde compared with the wild-type littermates.	Water	106-121	Bmi1 polycomb ring finger oncogene	Mus musculus	15-20
24030355-4	2014	Data indicate that H19, a paternally imprinted gene, compared to control embryos, was less methylated in 8-cell embryos from pregnant mice treated with NaF (100 mg/l) in drinking water for 48 h. Peg3, a maternally imprinted gene, and the Line1 repeated sequence were similarly methylated in NaF-treated and control embryos.	Water	179-184	paternally expressed 3	Mus musculus	195-199
24268174-4	2014	It is known that As(V) can be more easily removed from water by adsorptive methods than As(III).	Water	55-60	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	17-22
24292693-6	2014	The partition coefficient studies of different metal ions in the material were performed in demineralised water and different surfactant media, and it was found to be selective for Pb(II) and Hg(II) ions.	Water	106-111	submaxillary gland androgen regulated protein 3B	Homo sapiens	181-198
24389345-4	2014	In renal medulla, water deprivation induced alterations in the expression of miR-466(a/b/c/e/p)-3p in a pattern similar to that of miR-200b-3p, a known regulator of osmoresponsive transcription factor Nfat5.	Water	18-23	CDC42 effector protein (Rho GTPase binding) 3	Mus musculus	89-98
24286224-6	2014	We confirmed high H2O2 permeability of the human aquaammoniaporin AQP8 and found intermediate H2O2 permeability of the prototypical orthodox water channel AQP1 from the rat.	Water	141-146	aquaporin 1 (Colton blood group)	Homo sapiens	155-159
31986579-1	2014	By using a rigid multicarboxylate ligand, 4,5-di(4"-carboxylphenyl)phthalic acid (H4 L), two CoII complexes formulated as [Co4 L2 (4,4"-bpy)(H2 O)6 ] 3.5 H2 O (4,4"-bpy=4,4"-bipyridine) (1) and [Co2 L(azene)(H2 O)3 ] DMF (azene=(E)-1,2-di(pyridin-4-yl)diazene, DMF=dimethylformamide) (2) have been synthesized and structurally characterized by single-crystal X-ray diffraction.	Water	141-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
31986579-1	2014	By using a rigid multicarboxylate ligand, 4,5-di(4"-carboxylphenyl)phthalic acid (H4 L), two CoII complexes formulated as [Co4 L2 (4,4"-bpy)(H2 O)6 ] 3.5 H2 O (4,4"-bpy=4,4"-bipyridine) (1) and [Co2 L(azene)(H2 O)3 ] DMF (azene=(E)-1,2-di(pyridin-4-yl)diazene, DMF=dimethylformamide) (2) have been synthesized and structurally characterized by single-crystal X-ray diffraction.	Water	195-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
24812960-7	2014	The removal efficiency of COD and UV254 were 40.8% and 45.8% when the hydraulic retention time was 3 hours and the gas to water ratio was 3:1 for BAF.	Water	122-127	BAF nuclear assembly factor 1	Homo sapiens	146-149
24269698-3	2014	Previously, we have shown that water-damaged building associated trichothecene mycotoxins, including roridin A, trigger IL-1beta and IL-18 secretion in human macrophages.	Water	31-36	interleukin 1 beta	Homo sapiens	120-128
24336758-5	2014	The soluble water extract (SWE) from satsuma increased the production of prostaglandin E2 (PGE2) and promoted the expression level of cyclooxygenase-2 (COX-2) mRNA.	Water	12-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-150
24336758-5	2014	The soluble water extract (SWE) from satsuma increased the production of prostaglandin E2 (PGE2) and promoted the expression level of cyclooxygenase-2 (COX-2) mRNA.	Water	12-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	152-157
23868683-10	2014	The fastest runners were able to tolerate a greater variation in core temperature between the beginning and the end of the trail race with lower water intake.	Water	145-150	TNF superfamily member 10	Homo sapiens	123-128
24291767-4	2014	The experimental approach consists in studying FTIR spectra of intrinsic chromophores and VT-NMR measurements on lysozyme water mixtures in the presence of trehalose.	Water	122-127	lysozyme	Homo sapiens	113-121
24338365-8	2014	We conclude that water fluxes accompanying CFTR activity are linked to AQP3 but not to a cAMP-stimulated aqueous pore in the CFTR protein.	Water	17-22	CF transmembrane conductance regulator	Homo sapiens	43-47
24311819-2	2014	Water is transported radially into xylem vessels, under some conditions even when the xylem sap is more dilute than the ambient medium (soil solution).	Water	0-5	SH2 domain containing 1A	Homo sapiens	92-95
24311819-7	2014	According to the model, solutes released by xylem parenchyma cells are subsequently retrieved from the sap at the expense of metabolic energy to maintain the concentration gradient that drives the water secretion.	Water	197-202	SH2 domain containing 1A	Homo sapiens	103-106
24749461-1	2014	The condensation of water is a phenomenon occurring in multiple situations in everyday life, e.g., when fog is formed or when dew forms on the grass or on windows.	Water	20-25	zinc finger protein, FOG family member 1	Homo sapiens	104-107
23979260-8	2014	A second controlled synthesis and CEST study of EuDOTA-[(S)-Asp]4 and cis-EuDOTA-[(S)-Asp]2[(R)-Asp]2 confirmed that the water exchange rates in these diastereomeric complexes are controlled by the axial versus equatorial orientation of the carboxyl groups on the amide side chains.	Water	121-126	napsin A aspartic peptidase	Homo sapiens	60-65
23979260-8	2014	A second controlled synthesis and CEST study of EuDOTA-[(S)-Asp]4 and cis-EuDOTA-[(S)-Asp]2[(R)-Asp]2 confirmed that the water exchange rates in these diastereomeric complexes are controlled by the axial versus equatorial orientation of the carboxyl groups on the amide side chains.	Water	121-126	beta-secretase 1	Homo sapiens	86-91
23979260-8	2014	A second controlled synthesis and CEST study of EuDOTA-[(S)-Asp]4 and cis-EuDOTA-[(S)-Asp]2[(R)-Asp]2 confirmed that the water exchange rates in these diastereomeric complexes are controlled by the axial versus equatorial orientation of the carboxyl groups on the amide side chains.	Water	121-126	beta-secretase 1	Homo sapiens	96-101
24338365-2	2014	As an example, in epithelial cells it was proposed that the movement of water could be directly linked to cystic fibrosis transmembrane conductance regulator (CFTR) protein activity through a cAMP-stimulated aqueous pore, or be dependent on aquaporin.	Water	72-77	CF transmembrane conductance regulator	Homo sapiens	106-157
24338365-2	2014	As an example, in epithelial cells it was proposed that the movement of water could be directly linked to cystic fibrosis transmembrane conductance regulator (CFTR) protein activity through a cAMP-stimulated aqueous pore, or be dependent on aquaporin.	Water	72-77	CF transmembrane conductance regulator	Homo sapiens	159-163
24338365-3	2014	Here, we used digital holographic microscopy (DHM) an interferometric technique to quantify in situ the transmembrane water fluxes during the activity of the epithelial chloride channel, CFTR, measured by patch-clamp and iodide efflux techniques.	Water	118-123	CF transmembrane conductance regulator	Homo sapiens	187-191
24338365-4	2014	We showed that the water transport measured by DHM is fully inhibited by the selective CFTR blocker CFTRinh172 and is absent in cells lacking CFTR.	Water	19-24	CF transmembrane conductance regulator	Homo sapiens	87-91
24338365-4	2014	We showed that the water transport measured by DHM is fully inhibited by the selective CFTR blocker CFTRinh172 and is absent in cells lacking CFTR.	Water	19-24	CF transmembrane conductance regulator	Homo sapiens	100-104
24338365-5	2014	Of note, in cells expressing the mutated version of CFTR (F508del-CFTR), which mimics the most common genetic alteration encountered in cystic fibrosis, we also show that the water movement is profoundly altered but restored by pharmacological manipulation of F508del-CFTR-defective trafficking.	Water	175-180	CF transmembrane conductance regulator	Homo sapiens	52-56
24338365-5	2014	Of note, in cells expressing the mutated version of CFTR (F508del-CFTR), which mimics the most common genetic alteration encountered in cystic fibrosis, we also show that the water movement is profoundly altered but restored by pharmacological manipulation of F508del-CFTR-defective trafficking.	Water	175-180	CF transmembrane conductance regulator	Homo sapiens	58-70
24381103-2	2014	The amino acid sequence analysis revealed that sheep YAP1 gene encoded water-soluble protein and its relative molecular weight and isoelectric point was 44,079.0 Da and 4.91, respectively.	Water	71-76	transcriptional coactivator YAP1	Ovis aries	53-57
24338365-5	2014	Of note, in cells expressing the mutated version of CFTR (F508del-CFTR), which mimics the most common genetic alteration encountered in cystic fibrosis, we also show that the water movement is profoundly altered but restored by pharmacological manipulation of F508del-CFTR-defective trafficking.	Water	175-180	CF transmembrane conductance regulator	Homo sapiens	260-272
24338365-6	2014	Importantly, whereas activation of this endogenous water channel required a cAMP-dependent stimulation of CFTR, activation of CFTR or F508del-CFTR by two cAMP-independent CFTR activators, genistein and MPB91, failed to trigger water movements.	Water	51-56	CF transmembrane conductance regulator	Homo sapiens	106-110
24338365-6	2014	Importantly, whereas activation of this endogenous water channel required a cAMP-dependent stimulation of CFTR, activation of CFTR or F508del-CFTR by two cAMP-independent CFTR activators, genistein and MPB91, failed to trigger water movements.	Water	51-56	CF transmembrane conductance regulator	Homo sapiens	126-130
24338365-6	2014	Importantly, whereas activation of this endogenous water channel required a cAMP-dependent stimulation of CFTR, activation of CFTR or F508del-CFTR by two cAMP-independent CFTR activators, genistein and MPB91, failed to trigger water movements.	Water	51-56	CF transmembrane conductance regulator	Homo sapiens	134-146
24338365-6	2014	Importantly, whereas activation of this endogenous water channel required a cAMP-dependent stimulation of CFTR, activation of CFTR or F508del-CFTR by two cAMP-independent CFTR activators, genistein and MPB91, failed to trigger water movements.	Water	51-56	CF transmembrane conductance regulator	Homo sapiens	126-130
24338365-7	2014	Finally, using a specific small-interfering RNA against the endogenous aquaporin AQP3, the water transport accompanying CFTR activity decreased.	Water	91-96	CF transmembrane conductance regulator	Homo sapiens	120-124
25353519-0	2014	1/ f Fluctuations of amino acids regulate water transportation in aquaporin 1.	Water	42-47	aquaporin 1 (Colton blood group)	Homo sapiens	66-77
25353519-8	2014	As a result, we confirm that 1/f fluctuations of amino acids contribute to water transportation in AQP1.	Water	75-80	aquaporin 1 (Colton blood group)	Homo sapiens	99-103
25669552-3	2014	The employed ion force fields consist of one Lennard-Jones (LJ) site and one concentric point charge with a magnitude of +-1 e. The SPC/E model is used for water.	Water	156-161	proline rich protein gene cluster	Homo sapiens	132-135
24299758-3	2014	The water adsorption of the CMKGM/SPI films progressively decreased with increasing CMKGM level, the surface wettability of the blended films was improved with increasing CMKGM content; the CMKGM/SPI blend films had enhanced tensile strength (TS) and elongation at break (EAB) compared to pure CMKGM and SPI films; the oxygen permeability of blend films was decreased; the roughness was decreased with increasing CMKGM content.	Water	4-9	chromogranin A	Homo sapiens	28-37
24299758-3	2014	The water adsorption of the CMKGM/SPI films progressively decreased with increasing CMKGM level, the surface wettability of the blended films was improved with increasing CMKGM content; the CMKGM/SPI blend films had enhanced tensile strength (TS) and elongation at break (EAB) compared to pure CMKGM and SPI films; the oxygen permeability of blend films was decreased; the roughness was decreased with increasing CMKGM content.	Water	4-9	chromogranin A	Homo sapiens	34-37
24299758-3	2014	The water adsorption of the CMKGM/SPI films progressively decreased with increasing CMKGM level, the surface wettability of the blended films was improved with increasing CMKGM content; the CMKGM/SPI blend films had enhanced tensile strength (TS) and elongation at break (EAB) compared to pure CMKGM and SPI films; the oxygen permeability of blend films was decreased; the roughness was decreased with increasing CMKGM content.	Water	4-9	chromogranin A	Homo sapiens	196-199
24296768-0	2014	Water-soluble noncovalent adducts of the heterometallic copper subgroup complexes and human serum albumin with remarkable luminescent properties.	Water	0-5	albumin	Homo sapiens	92-105
24296768-1	2014	Novel water-soluble noncovalent adducts of the heterometallic copper subgroup complexes and human serum albumin (HSA) display strong phosphorescence, internalize into HeLa cells and can be used in time-resolved fluorescent imaging.	Water	6-11	albumin	Homo sapiens	98-111
24309292-5	2014	DSS in the drinking water, significantly decreased EphB6 protein expression levels in neurons of the lower thoracic superficial layers of spinal dorsal horns, the location of neurons that receive the majority of nociceptive information from the colon, via the primary afferents.	Water	20-25	Eph receptor B6	Mus musculus	51-56
24157333-1	2014	A pair of chiral compounds S-1 and R-1 derived from (1S, 2S) or (1R, 2R)-1, 2-diphenylethane-1, 2-diamine were designed and synthesized, the interactions of S-1 and R-1 with mandelate were studied in H2O (0.01 M HEPES buffer, pH=7.4) by fluorescence titration experiments.	Water	200-203	proteasome 26S subunit, non-ATPase 1	Homo sapiens	27-38
24744880-8	2014	However, water resorption and I SC were only moderately affected by forskolin or cystic fibrosis transmembrane regulator (CFTR) channel inhibitors (CFTRinh-172 and glybenclamide).	Water	9-14	CF transmembrane conductance regulator	Homo sapiens	81-120
24354363-2	2014	Because these phenomena are also influenced by the net charge content on the protein, the present study examines the association of water with cytochrome c held at different pH values so as to allow its side chains to ionize to variable extents.	Water	132-137	cytochrome c, somatic	Homo sapiens	143-155
24354363-3	2014	Equilibrium unfolding of differently charged cytochrome c molecules in water-methanol binary mixtures, where the alcohol acts as the cosolvent denaturant, was used to quantify the preferential exclusion of water during the unfolding transition.	Water	71-76	cytochrome c, somatic	Homo sapiens	45-57
24354363-3	2014	Equilibrium unfolding of differently charged cytochrome c molecules in water-methanol binary mixtures, where the alcohol acts as the cosolvent denaturant, was used to quantify the preferential exclusion of water during the unfolding transition.	Water	206-211	cytochrome c, somatic	Homo sapiens	45-57
24369906-1	2014	Horse muscle myoglobin (Mb) was tightly immobilized at Au-deposited ~15-A-thick mixed-type (1:1) alkanethiol SAMs, HS-(CH2)11-COOH/HS-(CH2)11-OH, and placed in contact with buffered H2O or D2O solutions.	Water	182-185	myoglobin	Equus caballus	13-22
24373533-0	2014	Facile preparation of raisin-bread sandwich-structured magnetic graphene/mesoporous silica composites with C18-modified pore-walls for efficient enrichment of phthalates in environmental water.	Water	187-192	Bardet-Biedl syndrome 9	Homo sapiens	107-110
24373533-7	2014	Finally, mag-graphene@mSiO2-C18 composites were successfully applied to analyzing phthalates in environmental water samples.	Water	110-115	Bardet-Biedl syndrome 9	Homo sapiens	28-31
24430057-3	2014	Here we show that Si nanoarray/PEDOT:PSS hybrid solar cells with improved stability can be fabricated via eliminating the water inclusion in the initial formation of the heterojunction between Si nanoarray and PEDOT:PSS.	Water	122-127	PSS	Homo sapiens	37-40
24430057-3	2014	Here we show that Si nanoarray/PEDOT:PSS hybrid solar cells with improved stability can be fabricated via eliminating the water inclusion in the initial formation of the heterojunction between Si nanoarray and PEDOT:PSS.	Water	122-127	PSS	Homo sapiens	216-219
24578654-4	2014	In the title complex, the Co(II) ion is six-coordinated by two pyridine N atoms and two carboxyl O atoms from two 2-picolinic acid anions, and two O atoms from two H2O molecules, and forming a slightly distorted octahedral geometry.	Water	164-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
24744880-8	2014	However, water resorption and I SC were only moderately affected by forskolin or cystic fibrosis transmembrane regulator (CFTR) channel inhibitors (CFTRinh-172 and glybenclamide).	Water	9-14	CF transmembrane conductance regulator	Homo sapiens	122-126
24744880-9	2014	In line with previous studies, we demonstrate that water resorption depends on ENaC, and CFTR channels have only a minor but probably modulating effect on water resorption.	Water	155-160	CF transmembrane conductance regulator	Homo sapiens	89-93
24217742-1	2014	A coumarin TCF-based water-soluble near-infrared fluorescent probe was presented, which could be used for the rapid, colorimetric and ratiometric detection of SO2 derivatives with a detection limit of 0.27 nM.	Water	21-26	hepatocyte nuclear factor 4 alpha	Homo sapiens	11-14
26579919-10	2014	We carried out an extended set of MD simulations of canonical A-RNA duplexes with TIP3P, TIP4P/2005, TIP5P, and SPC/E explicit water models and found that different water models provided a different extent of water bridging between 2"-OH groups across the minor groove, which in turn influences their distance and consequently also inclination, roll, and slide parameters.	Water	127-132	proline rich protein gene cluster	Homo sapiens	112-115
26579919-10	2014	We carried out an extended set of MD simulations of canonical A-RNA duplexes with TIP3P, TIP4P/2005, TIP5P, and SPC/E explicit water models and found that different water models provided a different extent of water bridging between 2"-OH groups across the minor groove, which in turn influences their distance and consequently also inclination, roll, and slide parameters.	Water	165-170	proline rich protein gene cluster	Homo sapiens	112-115
26579919-10	2014	We carried out an extended set of MD simulations of canonical A-RNA duplexes with TIP3P, TIP4P/2005, TIP5P, and SPC/E explicit water models and found that different water models provided a different extent of water bridging between 2"-OH groups across the minor groove, which in turn influences their distance and consequently also inclination, roll, and slide parameters.	Water	165-170	proline rich protein gene cluster	Homo sapiens	112-115
24200745-5	2014	Using erythropoietin as a protein drug, it was also exemplified that the released protein retained its cell proliferation activity even after rigorous formulation processes, including water-in-oil emulsion.	Water	184-189	erythropoietin	Homo sapiens	6-20
24251311-2	2014	Using denatured bovine serum albumin (dBSA), in which 35 cysteine residues can interact polyvalently with Au nanoclusters (AuNCs) as a stabilizing agent, water-soluble and stable fluorescent gold nanoclusters were synthesized.	Water	154-159	albumin	Homo sapiens	23-36
24419156-7	2014	Structural analysis of scFv-S93T:METH revealed that the substitution of Ser residue by Thr caused the expulsion of a water molecule from the cavity, creating a more hydrophobic environment for the binding that dramatically increases the affinities for METH and AMP.	Water	117-122	immunglobulin heavy chain variable region	Homo sapiens	23-27
24405844-1	2014	BACKGROUND: The major intrinsic protein gene (MIP), also known as MIP26 or AQP0, is a member of the water-transporting aquaporin family, which plays a critical role in the maintenance of lifelong lens transparency.	Water	100-105	major intrinsic protein of lens fiber	Homo sapiens	46-49
24405844-1	2014	BACKGROUND: The major intrinsic protein gene (MIP), also known as MIP26 or AQP0, is a member of the water-transporting aquaporin family, which plays a critical role in the maintenance of lifelong lens transparency.	Water	100-105	major intrinsic protein of lens fiber	Homo sapiens	66-71
24405844-1	2014	BACKGROUND: The major intrinsic protein gene (MIP), also known as MIP26 or AQP0, is a member of the water-transporting aquaporin family, which plays a critical role in the maintenance of lifelong lens transparency.	Water	100-105	major intrinsic protein of lens fiber	Homo sapiens	75-79
24328100-0	2014	Analysis of the hydration water around bovine serum albumin using terahertz coherent synchrotron radiation.	Water	26-31	albumin	Homo sapiens	46-59
24328100-1	2014	Terahertz spectroscopy was used to study the absorption of bovine serum albumin (BSA) in water.	Water	89-94	albumin	Homo sapiens	66-79
24367080-4	2014	Here, we unravel how FaPIP1;1, a fruit-specific PIP1 aquaporin from Fragaria x ananassa, contributes to the modulation of membrane water permeability (Pf) and pH aquaporin regulation.	Water	131-136	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	23-27
24283196-1	2014	The intermolecular interaction between mefenamic acid (MFA), a poorly water-soluble nonsteroidal anti-inflammatory drug, and Eudragit EPO (EPO), a water-soluble polymer, is investigated in their supersaturated solution using high-resolution magic-angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy.	Water	147-152	erythropoietin	Homo sapiens	134-137
25504362-7	2014	Polymorphisms of eleven genes have been associated with stones in genome-wide association studies and replicated candidate-gene association studies: VDR, SLC34A1, SLC34A4, CLDN14, and CaSR genes coding for proteins regulating tubular phosphate and calcium reabsorption; CaSR, MGP, OPN, PLAU, and UMOD genes coding for proteins preventing calcium salt precipitation; AQP1 gene coding for a water channel in the proximal tubule.	Water	389-394	claudin 14	Homo sapiens	172-178
24829994-9	2014	Lesion techniques have shown that ablation of the SFO or the periventricular area containing the OVLT dramatically reduces the water or NaCl intake stimulated by AngII (Buggy and Johnson 1978; Morris et al.	Water	127-132	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	162-167
24829994-12	2014	Small amounts of AngII injected directly into the SFO or OVLT, on the other hand, increase water and NaCl intake (Mangiapane and Simpson 1979, 1980).	Water	91-96	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	17-22
24829994-33	2014	Mice with genetic disruption of the gene for the AT1 receptor have a severely impaired water intake response to AngII injection (Li et al.	Water	87-92	angiotensin II receptor, type 1a	Mus musculus	49-52
24829994-33	2014	Mice with genetic disruption of the gene for the AT1 receptor have a severely impaired water intake response to AngII injection (Li et al.	Water	87-92	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	112-117
24829994-48	2014	Specifically, lateral ventricle injections of ~5 ng of AngII are sufficient to stimulate water intake in rats, but far greater amounts (~100-200 ng) are needed to stimulate water intake in mice and AngII is surprisingly not dipsetic when injected peripherally in mice (Rowland et al.	Water	89-94	angiotensinogen	Rattus norvegicus	55-60
24197065-3	2014	Segment types were characterized on the basis of structural features and gene expression levels of the water channel aquaporin 1, which was high in the upper DTL (DTLupper), absent in the lower DTL (DTLlower), and absent in ATLs, and the Cl-(1) channel ClCK1, which was absent in DTLs and high in ATLs.	Water	103-108	chloride voltage-gated channel Ka	Rattus norvegicus	253-258
25504362-7	2014	Polymorphisms of eleven genes have been associated with stones in genome-wide association studies and replicated candidate-gene association studies: VDR, SLC34A1, SLC34A4, CLDN14, and CaSR genes coding for proteins regulating tubular phosphate and calcium reabsorption; CaSR, MGP, OPN, PLAU, and UMOD genes coding for proteins preventing calcium salt precipitation; AQP1 gene coding for a water channel in the proximal tubule.	Water	389-394	calcium sensing receptor	Homo sapiens	184-188
24144549-1	2014	A single central injection of angiotensin II (AngII) potently increases water intake; however, a growing body of research suggests that repeated, acute intracerebroventricular injections of AngII cause a reduction in the dipsogenic response to subsequent AngII.	Water	72-77	angiotensinogen	Homo sapiens	30-44
24903643-3	2014	Milk was contaminated with bacteria or adulterated with water, flour, chalk and other substances.	Water	56-61	Weaning weight-maternal milk	Bos taurus	0-4
25206049-4	2014	The treated group was given desvenlafaxine orally in the dose of 80 mg/kg from 1(st) to 6(th) day of gestation and other group was given tap water by same route.	Water	141-146	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	137-140
24068473-0	2014	DNA-binding studies and antitumor evaluation of novel water soluble organic pip and hpip analogs.	Water	54-59	prolactin induced protein	Homo sapiens	76-79
24068473-0	2014	DNA-binding studies and antitumor evaluation of novel water soluble organic pip and hpip analogs.	Water	54-59	host cell factor C1 regulator 1	Homo sapiens	84-88
24068473-1	2014	Two new water-soluble pip and hpip analogs, 1 and 2 pip = 2-phenylimidazo[4,5-f][1, 10]phenanthroline; hpip = 2-(2-hydroxyphenyl)imidazo[4,5-f][1, 10]phenanthroline, have been synthesized and fully characterized by CHN analysis, MALDI-TOF MS, (1)H-NMR, IR (ATR), and UV-Vis methods.	Water	8-13	prolactin induced protein	Homo sapiens	22-25
24068473-1	2014	Two new water-soluble pip and hpip analogs, 1 and 2 pip = 2-phenylimidazo[4,5-f][1, 10]phenanthroline; hpip = 2-(2-hydroxyphenyl)imidazo[4,5-f][1, 10]phenanthroline, have been synthesized and fully characterized by CHN analysis, MALDI-TOF MS, (1)H-NMR, IR (ATR), and UV-Vis methods.	Water	8-13	host cell factor C1 regulator 1	Homo sapiens	30-34
24068473-1	2014	Two new water-soluble pip and hpip analogs, 1 and 2 pip = 2-phenylimidazo[4,5-f][1, 10]phenanthroline; hpip = 2-(2-hydroxyphenyl)imidazo[4,5-f][1, 10]phenanthroline, have been synthesized and fully characterized by CHN analysis, MALDI-TOF MS, (1)H-NMR, IR (ATR), and UV-Vis methods.	Water	8-13	prolactin induced protein	Homo sapiens	31-34
24068473-1	2014	Two new water-soluble pip and hpip analogs, 1 and 2 pip = 2-phenylimidazo[4,5-f][1, 10]phenanthroline; hpip = 2-(2-hydroxyphenyl)imidazo[4,5-f][1, 10]phenanthroline, have been synthesized and fully characterized by CHN analysis, MALDI-TOF MS, (1)H-NMR, IR (ATR), and UV-Vis methods.	Water	8-13	host cell factor C1 regulator 1	Homo sapiens	103-107
24013113-1	2014	There is a large number of boron containing minerals with water and/or hydroxyl units of which pinnoite MgB2O(OH)6 is one.	Water	58-63	secretoglobin family 2A member 1	Homo sapiens	104-108
24144549-1	2014	A single central injection of angiotensin II (AngII) potently increases water intake; however, a growing body of research suggests that repeated, acute intracerebroventricular injections of AngII cause a reduction in the dipsogenic response to subsequent AngII.	Water	72-77	angiotensinogen	Homo sapiens	46-51
24144549-1	2014	A single central injection of angiotensin II (AngII) potently increases water intake; however, a growing body of research suggests that repeated, acute intracerebroventricular injections of AngII cause a reduction in the dipsogenic response to subsequent AngII.	Water	72-77	angiotensinogen	Homo sapiens	190-195
24144549-1	2014	A single central injection of angiotensin II (AngII) potently increases water intake; however, a growing body of research suggests that repeated, acute intracerebroventricular injections of AngII cause a reduction in the dipsogenic response to subsequent AngII.	Water	72-77	angiotensinogen	Homo sapiens	190-195
24144549-6	2014	In support of this hypothesis, we found that repeated injections of AngII into the AV3V reduced water intake stimulated by a test injection of AngII given into this region.	Water	96-101	angiotensinogen	Homo sapiens	68-73
24144549-6	2014	In support of this hypothesis, we found that repeated injections of AngII into the AV3V reduced water intake stimulated by a test injection of AngII given into this region.	Water	96-101	angiotensinogen	Homo sapiens	143-148
24144549-7	2014	Moreover, repeated AngII injections in the AV3V reduced water intake after AngII was injected into the lateral ventricle.	Water	56-61	angiotensinogen	Homo sapiens	19-24
24717924-2	2014	AQP3, AQP7, and AQP9, termed aqua-glyceroporins, are known to be involved in the transport of water, glycerol, and other small molecules.	Water	94-99	aquaporin 9	Rattus norvegicus	16-20
25355439-0	2014	Effect of Coptidis Rhizoma extracts in a water-based solution on insulin resistance in 3T3-L1 adipocytes.	Water	41-46	insulin	Homo sapiens	65-72
24315190-8	2014	But, the presence of this aliphatic hydroxyl is not required in all compounds, since mono-hydroxyl (phenolic) compounds bind ERalpha with high affinity, via hydroxyl hydrogen bonding interactions with the ERalpha Arg394/Glu353/water triad, and van der Waals interactions with the rest of the molecule.	Water	227-232	estrogen receptor 1	Homo sapiens	205-212
24333057-1	2014	BACKGROUND: The Colton blood group antigens Co(a), Co(b) and Co3 are encoded by the AQP1 gene which produces a water channel forming integral protein.	Water	111-116	aquaporin 1 (Colton blood group)	Homo sapiens	84-88
29421628-1	2014	The anti-diuretic hormone arginine-vasopressin (AVP) is released from the pituitary and regulates water reabsorption in the principal cells of the kidney collecting duct.	Water	98-103	arginine vasopressin	Homo sapiens	35-46
29421628-1	2014	The anti-diuretic hormone arginine-vasopressin (AVP) is released from the pituitary and regulates water reabsorption in the principal cells of the kidney collecting duct.	Water	98-103	arginine vasopressin	Homo sapiens	48-51
29421628-2	2014	Binding of AVP to the arginine-vasopressin receptor type-2 in the basolateral membrane leads to translocation of aquaporin-2 water channels to the apical membrane of the principal cells of the collecting duct, inducing water permeability of the membrane.	Water	125-130	arginine vasopressin	Homo sapiens	11-14
29421628-2	2014	Binding of AVP to the arginine-vasopressin receptor type-2 in the basolateral membrane leads to translocation of aquaporin-2 water channels to the apical membrane of the principal cells of the collecting duct, inducing water permeability of the membrane.	Water	125-130	arginine vasopressin	Homo sapiens	31-42
29421628-2	2014	Binding of AVP to the arginine-vasopressin receptor type-2 in the basolateral membrane leads to translocation of aquaporin-2 water channels to the apical membrane of the principal cells of the collecting duct, inducing water permeability of the membrane.	Water	219-224	arginine vasopressin	Homo sapiens	11-14
29421628-2	2014	Binding of AVP to the arginine-vasopressin receptor type-2 in the basolateral membrane leads to translocation of aquaporin-2 water channels to the apical membrane of the principal cells of the collecting duct, inducing water permeability of the membrane.	Water	219-224	arginine vasopressin	Homo sapiens	31-42
25477042-1	2014	The hypothalamic nonapeptide and neurohypophyseal hormone arg-vasopressin (AVP), also known as antidiuretic hormone, is best known for its effects on water reabsorption in kidney.	Water	150-155	arginine vasopressin	Homo sapiens	95-115
24853354-7	2014	Vasopressin plays a hormonal function in the mechanisms of water homeostasis acting through Aquaporins (AQP), channel-proteins that allow bi-directional water transport across cell membranes.	Water	59-64	arginine vasopressin	Homo sapiens	0-11
24853354-7	2014	Vasopressin plays a hormonal function in the mechanisms of water homeostasis acting through Aquaporins (AQP), channel-proteins that allow bi-directional water transport across cell membranes.	Water	153-158	arginine vasopressin	Homo sapiens	0-11
23755720-1	2014	An efficient synthesis of 1,3-oxathiolan-2-yliden derivatives is described via a simple reactions between CHacids, CS2 and oxiranes in the presence of triethylamine at 70  C in water as the solvent.	Water	177-182	chorionic somatomammotropin hormone 2	Homo sapiens	115-118
24755862-3	2014	CFTR (cystic fibrosis transmembrane conductance regulator) is a cAMP-regulated Cl(-) channel in the apical membrane of epithelium that contributes to salt and water secretion onto the luminal surface of airways, thereby ensuring that secreted mucus is sufficiently hydrated for movement along the epithelial surface.	Water	159-164	CF transmembrane conductance regulator	Homo sapiens	0-4
24755862-3	2014	CFTR (cystic fibrosis transmembrane conductance regulator) is a cAMP-regulated Cl(-) channel in the apical membrane of epithelium that contributes to salt and water secretion onto the luminal surface of airways, thereby ensuring that secreted mucus is sufficiently hydrated for movement along the epithelial surface.	Water	159-164	CF transmembrane conductance regulator	Homo sapiens	6-57
24717924-11	2014	AQP3 and AQP9 facilitate both transcellular osmotic water flow and glycerol transport as pore-like passive transporters in the keratinocytes of oral epithelia, and may play a key role in not only hydration and the permeability barrier, but also cell proliferation, differentiation, migration, development, and wound healing by generating ATP.	Water	52-57	aquaporin 9	Rattus norvegicus	9-13
23314707-6	2014	Water quality criteria, expressed as hazardous concentration for 5% of species (HC5), were derived by use of several approaches.	Water	0-5	CYCS pseudogene 1	Homo sapiens	80-83
24304979-9	2014	SUMMARY: Originally identified as a target of E. coli enterotoxin STa, GC-C is an important regulator of physiological salt and water homeostasis and may directly impact a wide range of intestinal disorders.	Water	128-133	guanylate cyclase 2c	Mus musculus	71-75
24189755-7	2014	Average annual nutrient concentrations in the water were 0.21 +- 0.1 muM for phosphate, 0.08 +- 0.1 muM for nitrite, 0.74 +- 1.6 muM for nitrate, and 1.27 +- 1.1 muM for ammonium.	Water	46-51	latexin	Homo sapiens	69-72
24189755-7	2014	Average annual nutrient concentrations in the water were 0.21 +- 0.1 muM for phosphate, 0.08 +- 0.1 muM for nitrite, 0.74 +- 1.6 muM for nitrate, and 1.27 +- 1.1 muM for ammonium.	Water	46-51	latexin	Homo sapiens	100-103
24189755-7	2014	Average annual nutrient concentrations in the water were 0.21 +- 0.1 muM for phosphate, 0.08 +- 0.1 muM for nitrite, 0.74 +- 1.6 muM for nitrate, and 1.27 +- 1.1 muM for ammonium.	Water	46-51	latexin	Homo sapiens	100-103
24189755-7	2014	Average annual nutrient concentrations in the water were 0.21 +- 0.1 muM for phosphate, 0.08 +- 0.1 muM for nitrite, 0.74 +- 1.6 muM for nitrate, and 1.27 +- 1.1 muM for ammonium.	Water	46-51	latexin	Homo sapiens	100-103
25138914-3	2014	GABA binding is simulated with the occluded conformation of GAT1 homodimer in an explicit lipid/water environment.	Water	96-101	solute carrier family 6 member 1	Homo sapiens	60-64
23815567-3	2014	Multiple pathogenic mechanisms have been proposed, including insulin-induced sodium and water retention.	Water	88-93	insulin	Homo sapiens	61-68
23818078-13	2014	When arsenic levels in the water were reduced to below 50 mug L(-1) (Indian permissible limit), total arsenic intake and arsenic intake through the water significantly decreased, but arsenic uptake through the diet was found to be not significantly affected.	Water	27-32	immunoglobulin kappa variable 1-16	Homo sapiens	62-67
24749281-2	2014	As the solvent to obtain a working solution there was used distilled water solutions of different conccentrations were obtained on the base of Moscow tap water cleaned out by a charcoal filter.	Water	154-159	nuclear RNA export factor 1	Rattus norvegicus	150-153
25407040-1	2014	Three new supramolecular assemblies SA1-SA3 with different linkages between the photosensitizer and catalyst have been synthesized for light driven water oxidation.	Water	148-153	stromal antigen 1	Homo sapiens	36-39
24389258-6	2014	Simultaneous ingestion of coenzyme Q10 with drinking spa water returned mitochondrial parameters to the values of the control group.	Water	57-62	surfactant protein A1	Rattus norvegicus	53-56
24804063-0	2014	Hydration kinetics of direct expanded tef flour breakfast cereals in water and milk.	Water	69-74	TEF transcription factor, PAR bZIP family member	Homo sapiens	38-41
24247158-2	2014	Our previous study showed that water-soluble PLGA curcumin nanoparticles (Cur-NPs) triggered apoptotic cell death through regulation of the function of MDR1 and the production of reactive oxygen species (ROS) in cisplatin-resistant human oral cancer CAR cells.	Water	31-36	ATP binding cassette subfamily B member 1	Homo sapiens	152-156
23657866-3	2014	The BMCs seeded onto the PVF sponges with water-holding capability showed more significant increases in DNA content, alkaline phosphatase (ALP) activity, osteocalcin content, and calcium deposition than those without water-holding capability.	Water	42-47	bone gamma-carboxyglutamate protein	Rattus norvegicus	154-165
24426047-6	2014	These results suggest that DIC process can be applied in green tea processing for both a traditional product and a new kind of tea capable of making with cold water.	Water	159-164	solute carrier family 25 member 10	Homo sapiens	27-30
23527826-3	2014	Herein, computational approaches were used to provide a structural characterization of the binding site, flap opening and dynamic rearrangements of REN in the key conserved residues and water molecules, with the binding of a dodecapeptide substrate or different inhibitors.	Water	186-191	renin	Homo sapiens	148-151
23527826-9	2014	We additionally observed that the Tyr75-Trp39 H-bond has an important role in assisting flap movement, and we highlight several conserved water molecules and amino acids that are essential for the proper catalytic activity of REN.	Water	138-143	renin	Homo sapiens	226-229
24697170-2	2014	Scanning electron microscopic images (SEM) and dynamic light scattering (DLS) results indicate that the ES system can generate either a dry powder or a homogeneous water-based suspension of ALA/PEO/CS particles.	Water	164-169	twinkle mtDNA helicase	Homo sapiens	194-197
24558308-0	2014	Korean Red Ginseng water extract inhibits COX-2 expression by suppressing p38 in acrolein-treated human endothelial cells.	Water	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
24558308-0	2014	Korean Red Ginseng water extract inhibits COX-2 expression by suppressing p38 in acrolein-treated human endothelial cells.	Water	19-24	mitogen-activated protein kinase 14	Homo sapiens	74-77
25421594-0	2014	Water-extracted Ampelopsis brevipedunculata downregulates IL-1beta,CCL5, and COX-2 expression via inhibition of PKC-mediated JNK/NF-kappaB signaling pathways in human monocytic cells.	Water	0-5	interleukin 1 beta	Homo sapiens	58-66
25421594-0	2014	Water-extracted Ampelopsis brevipedunculata downregulates IL-1beta,CCL5, and COX-2 expression via inhibition of PKC-mediated JNK/NF-kappaB signaling pathways in human monocytic cells.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
25421594-0	2014	Water-extracted Ampelopsis brevipedunculata downregulates IL-1beta,CCL5, and COX-2 expression via inhibition of PKC-mediated JNK/NF-kappaB signaling pathways in human monocytic cells.	Water	0-5	mitogen-activated protein kinase 8	Homo sapiens	125-128
25421594-0	2014	Water-extracted Ampelopsis brevipedunculata downregulates IL-1beta,CCL5, and COX-2 expression via inhibition of PKC-mediated JNK/NF-kappaB signaling pathways in human monocytic cells.	Water	0-5	nuclear factor kappa B subunit 1	Homo sapiens	129-138
25421594-4	2014	THP-1 cells activated by PMA in the presence or absence of A.bre demonstrated that a water-extract of A.bre inhibited the expression of pro-inflammatory cytokine IL-1beta and chemokine CCL-5 in a dose-dependent manner.	Water	85-90	interleukin 1 beta	Homo sapiens	162-170
25421594-8	2014	Collectively, our data showed that water-extracted A.bre inhibited the protein kinase C-JNKs/NF-kappaB signaling pathways, resulting in the suppression of IL-1beta, CCL-5, and COX-2 expression.	Water	35-40	nuclear factor kappa B subunit 1	Homo sapiens	93-102
25421594-8	2014	Collectively, our data showed that water-extracted A.bre inhibited the protein kinase C-JNKs/NF-kappaB signaling pathways, resulting in the suppression of IL-1beta, CCL-5, and COX-2 expression.	Water	35-40	interleukin 1 beta	Homo sapiens	155-163
25421594-8	2014	Collectively, our data showed that water-extracted A.bre inhibited the protein kinase C-JNKs/NF-kappaB signaling pathways, resulting in the suppression of IL-1beta, CCL-5, and COX-2 expression.	Water	35-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
24754388-0	2014	Endocrine and AhR-CYP1A pathway responses to the water-soluble fraction of oil in zebrafish (Danio rerio Hamilton).	Water	49-54	cytochrome P450, family 1, subfamily A	Danio rerio	18-23
23950570-5	2014	The results of water deprivation test were compatible with a diagnosis of NDI.	Water	15-20	arginine vasopressin receptor 2	Homo sapiens	74-77
25047806-6	2014	These findings suggest that the water-soluble components of cigarette smoke may cause BSM hyperresponsiveness via an increase in MLCK and RhoA.	Water	32-37	myosin light chain kinase	Rattus norvegicus	129-133
24697170-3	2014	The SEM images revealed that the ALA/PEO/CS particles have a spherical shape with a diameter of approximately 707 +- 66.68 nm, and DLS showed that the ALA/PEO/CS particles suspended in deionised water have a diameter of 734.5 nm.	Water	195-200	twinkle mtDNA helicase	Homo sapiens	33-43
25277838-4	2014	The ESBL-producing E. coli from upstream water was resistant to 7 antibiotics, but isolates from feces and downstream water had a higher resistance rate.	Water	41-46	EsbL	Escherichia coli	4-8
25277838-4	2014	The ESBL-producing E. coli from upstream water was resistant to 7 antibiotics, but isolates from feces and downstream water had a higher resistance rate.	Water	118-123	EsbL	Escherichia coli	4-8
25277838-6	2014	Five ESBL-producing isolates from downstream water showed &gt;90% similarity with the fecal isolates, while the only one isolate from upstream water had &lt;70% similarity with fecal isolates.	Water	45-50	EsbL	Escherichia coli	5-9
25426863-5	2014	We constructed an atomic model for the chymopapain-cystatin dimer by docking the individual 3D protein structures; subsequently, the model was refined using a 100 ns NPT molecular dynamics simulation in explicit water.	Water	212-217	cystatin C	Gallus gallus	51-59
24683439-1	2014	Glutathione peroxidase-1 (GPx1) is a pivotal intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects.	Water	126-131	glutathione peroxidase 1	Rattus norvegicus	0-24
24683439-1	2014	Glutathione peroxidase-1 (GPx1) is a pivotal intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects.	Water	126-131	glutathione peroxidase 1	Rattus norvegicus	26-30
24200896-3	2014	To test this we activated heat-sensitive TRPV1 receptors in mice by water that is warmer than body temperature (41  C) or a low dose of resiniferatoxin (RTX).	Water	68-73	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	41-46
24875728-4	2014	The performance of the NF1 group was significantly lower on the Water and Key search subtest of the BADS-C and on four scales of the BRIEF: initiate; working memory; plan/organise and organisation of materials.	Water	64-69	neurofibromin 1	Homo sapiens	23-26
23818262-0	2014	How catalase recognizes H2O2 in a sea of water.	Water	41-46	catalase	Homo sapiens	4-12
23818262-3	2014	Using molecular dynamics simulations we addressed the question as to how catalase selects H2 O2 in water.	Water	99-104	catalase	Homo sapiens	73-81
23994821-6	2014	The water at the CWT outfall also had a mixture of inorganic and organic precursors including elevated concentrations of bromide (75 mg L(-1)) and other organic DBP precursors (phenol at 15 mug L(-1)).	Water	4-9	D-box binding PAR bZIP transcription factor	Homo sapiens	161-164
23994821-9	2014	Therefore, produced water brines that have been disinfected are potential sources of DBPs along with DBP precursors to streams wherever these wastewaters are discharged.	Water	20-25	D-box binding PAR bZIP transcription factor	Homo sapiens	85-88
24231744-0	2014	Highly stable water dispersible calix[4]pyrrole octa-hydrazide protected gold nanoparticles as colorimetric and fluorometric chemosensors for selective signaling of Co(II) ions.	Water	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-171
25621306-1	2014	Three active-site components in rhodopsin play a key role in the stability and function of the protein: 1) the counter-ion residues which stabilize the protonated Schiff base, 2) water molecules, and 3) the hydrogen-bonding network.	Water	179-184	rhodopsin	Homo sapiens	32-41
24206757-5	2014	Compared with ssDNA, HepG2 cells exposed to extracts of chlorine doped water for 24 h showed higher cytotoxicity, caspase 3/7 levels, DNA damage, micronuclei frequency, and decreased cell viability.	Water	71-76	caspase 3	Homo sapiens	114-123
25621306-2	2014	The ionizable residue Glu-181, which is involved in an extended hydrogen-bonding network with Ser-186, Tyr-268, Tyr-192, and key water molecules within the active site of rhodopsin, has been shown to be involved in a complex counter-ion switch mechanism with Glu-113 during the photobleaching sequence of the protein.	Water	129-134	rhodopsin	Homo sapiens	171-180
24263127-6	2014	Under condition in aqueous solution of sensor 3e (water/dimethylsulfoxide, 7:3, v/v), linearity range for the quantification of acetate anion was 1-22 muM and limit of detection (LOD) of acetate anion was 0.71 muM.	Water	50-55	latexin	Homo sapiens	151-154
24320737-5	2013	Above the limiting current, deionized water ( 10 muM) can be continuously extracted from the frit, which implies the existence of a stable shock propagating against the flow, bordering a depleted region that extends more than 0.5 mm across the outlet.	Water	38-43	latexin	Homo sapiens	49-52
25098870-4	2014	The reject water total P (TP) content from dewatering biosolids alone (250 mg L-1) was reduced to 60 mg L-1 for a BR = 1.5.	Water	11-16	immunoglobulin kappa variable 1-16	Homo sapiens	78-81
25098870-4	2014	The reject water total P (TP) content from dewatering biosolids alone (250 mg L-1) was reduced to 60 mg L-1 for a BR = 1.5.	Water	11-16	immunoglobulin kappa variable 1-16	Homo sapiens	104-107
24391659-9	2013	PA-dependent recruitment of glyceraldehyde-3-phosphate dehydrogenase under water limiting conditions indicates a role in regulating metabolic processes.	Water	75-80	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	28-68
24067938-8	2013	The detection limit of the sensor for Cu(2+) (1.5 muM) is far below the guidelines of the World Health Organization (30 muM) as the maximum allowable copper concentration in drinking water, and therefore it is capable of being a practical system for the monitoring of Cu(2+) concentrations in aqueous samples.	Water	183-188	latexin	Homo sapiens	50-53
24067938-8	2013	The detection limit of the sensor for Cu(2+) (1.5 muM) is far below the guidelines of the World Health Organization (30 muM) as the maximum allowable copper concentration in drinking water, and therefore it is capable of being a practical system for the monitoring of Cu(2+) concentrations in aqueous samples.	Water	183-188	latexin	Homo sapiens	120-123
24313458-9	2013	The results reveal that anhydrous SP conformers originate from evaporation of cluster ions, specifically, [SP + 2H](2+) (H2O)n (n = 0 to ~50) and [SP + 3H](3+) (H2O)n (n = 0 to ~30), and that major structural changes do not occur during the evaporative process.	Water	121-124	tachykinin precursor 1	Homo sapiens	34-36
24313458-9	2013	The results reveal that anhydrous SP conformers originate from evaporation of cluster ions, specifically, [SP + 2H](2+) (H2O)n (n = 0 to ~50) and [SP + 3H](3+) (H2O)n (n = 0 to ~30), and that major structural changes do not occur during the evaporative process.	Water	161-164	tachykinin precursor 1	Homo sapiens	34-36
24359587-7	2013	RESULTS: Particles generated from the humidifier operated with tap water had a mass concentration of 0.46 +- 0.03 mg/m3, number concentration of (5.0 +- 1.1) x 10(4)/cm3, and peak size distribution of 183 nm.	Water	67-72	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	63-66
24173030-2	2013	The spheres had a radiative structure from the center, and their diameters were controlled in the range from 1 to 5 mum by adjusting the volume of the reactant water.	Water	160-165	latexin	Homo sapiens	116-119
24359587-10	2013	CONCLUSION: These results indicate that aerosol particles released from ultrasonic humidifiers operated with tap water initiated a cellular response but did not cause severe acute inflammation in pulmonary tissue.	Water	113-118	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	109-112
24279370-1	2013	We introduce the novel Co4O4 complex [Co(II)4(hmp)4(mu-OAc)2(mu2-OAc)2(H2O)2] (1) (hmp = 2-(hydroxymethyl)pyridine) as the first Co(II)-based cubane water oxidation catalyst.	Water	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
27493555-2	2013	By applying attenuated total reflection (ATR) Fourier-transform infrared (FTIR) spectroscopy to a light-driven Cl(-) pump pharaonis halorhodopsin (pHR), here we detected an O-H stretching vibration of protein-bound water molecules in the active center.	Water	215-220	ATR serine/threonine kinase	Homo sapiens	41-44
27493555-2	2013	By applying attenuated total reflection (ATR) Fourier-transform infrared (FTIR) spectroscopy to a light-driven Cl(-) pump pharaonis halorhodopsin (pHR), here we detected an O-H stretching vibration of protein-bound water molecules in the active center.	Water	215-220	MYC binding protein 2	Homo sapiens	147-150
27493555-3	2013	The pHR(Cl(-)) minus pHR(Br(-)) ATR-FTIR spectra show random fluctuation at 3600-3000 cm(-1), frequency window of water vibration, which can be interpreted in terms of dynamical fluctuation of aqueous water at room temperature.	Water	114-119	MYC binding protein 2	Homo sapiens	4-7
27493555-3	2013	The pHR(Cl(-)) minus pHR(Br(-)) ATR-FTIR spectra show random fluctuation at 3600-3000 cm(-1), frequency window of water vibration, which can be interpreted in terms of dynamical fluctuation of aqueous water at room temperature.	Water	114-119	MYC binding protein 2	Homo sapiens	21-24
27493555-3	2013	The pHR(Cl(-)) minus pHR(Br(-)) ATR-FTIR spectra show random fluctuation at 3600-3000 cm(-1), frequency window of water vibration, which can be interpreted in terms of dynamical fluctuation of aqueous water at room temperature.	Water	114-119	ATR serine/threonine kinase	Homo sapiens	32-35
27493555-3	2013	The pHR(Cl(-)) minus pHR(Br(-)) ATR-FTIR spectra show random fluctuation at 3600-3000 cm(-1), frequency window of water vibration, which can be interpreted in terms of dynamical fluctuation of aqueous water at room temperature.	Water	201-206	MYC binding protein 2	Homo sapiens	4-7
27493555-3	2013	The pHR(Cl(-)) minus pHR(Br(-)) ATR-FTIR spectra show random fluctuation at 3600-3000 cm(-1), frequency window of water vibration, which can be interpreted in terms of dynamical fluctuation of aqueous water at room temperature.	Water	201-206	MYC binding protein 2	Homo sapiens	21-24
27493555-3	2013	The pHR(Cl(-)) minus pHR(Br(-)) ATR-FTIR spectra show random fluctuation at 3600-3000 cm(-1), frequency window of water vibration, which can be interpreted in terms of dynamical fluctuation of aqueous water at room temperature.	Water	201-206	ATR serine/threonine kinase	Homo sapiens	32-35
27493555-5	2013	The water O-H stretching vibrations of pHR(Cl(-)) and pHR(Br(-)) at 3617 and 3630 cm(-1), respectively, are confirmed by light-induced difference FTIR spectra in isotope water (H2 (18)O) at 77 K. The observed water molecule presumably binds to the active center of pHR, and alter its hydrogen bond during the Cl(-) pumping photocycle.	Water	4-9	MYC binding protein 2	Homo sapiens	39-42
27493555-5	2013	The water O-H stretching vibrations of pHR(Cl(-)) and pHR(Br(-)) at 3617 and 3630 cm(-1), respectively, are confirmed by light-induced difference FTIR spectra in isotope water (H2 (18)O) at 77 K. The observed water molecule presumably binds to the active center of pHR, and alter its hydrogen bond during the Cl(-) pumping photocycle.	Water	4-9	MYC binding protein 2	Homo sapiens	54-57
27493555-5	2013	The water O-H stretching vibrations of pHR(Cl(-)) and pHR(Br(-)) at 3617 and 3630 cm(-1), respectively, are confirmed by light-induced difference FTIR spectra in isotope water (H2 (18)O) at 77 K. The observed water molecule presumably binds to the active center of pHR, and alter its hydrogen bond during the Cl(-) pumping photocycle.	Water	4-9	MYC binding protein 2	Homo sapiens	54-57
27493555-5	2013	The water O-H stretching vibrations of pHR(Cl(-)) and pHR(Br(-)) at 3617 and 3630 cm(-1), respectively, are confirmed by light-induced difference FTIR spectra in isotope water (H2 (18)O) at 77 K. The observed water molecule presumably binds to the active center of pHR, and alter its hydrogen bond during the Cl(-) pumping photocycle.	Water	170-175	MYC binding protein 2	Homo sapiens	39-42
27493555-5	2013	The water O-H stretching vibrations of pHR(Cl(-)) and pHR(Br(-)) at 3617 and 3630 cm(-1), respectively, are confirmed by light-induced difference FTIR spectra in isotope water (H2 (18)O) at 77 K. The observed water molecule presumably binds to the active center of pHR, and alter its hydrogen bond during the Cl(-) pumping photocycle.	Water	170-175	MYC binding protein 2	Homo sapiens	54-57
27493555-5	2013	The water O-H stretching vibrations of pHR(Cl(-)) and pHR(Br(-)) at 3617 and 3630 cm(-1), respectively, are confirmed by light-induced difference FTIR spectra in isotope water (H2 (18)O) at 77 K. The observed water molecule presumably binds to the active center of pHR, and alter its hydrogen bond during the Cl(-) pumping photocycle.	Water	170-175	MYC binding protein 2	Homo sapiens	54-57
24279370-4	2013	The Co(II) core combines robustness and stability with flexibility through a new type of water-oxidation mechanism via mobile ligands.	Water	89-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24154696-1	2013	Binding of vasopressin to its type 2 receptor in renal collecting ducts induces cAMP signaling, transcription and translocation of aquaporin (AQP)2 water channels to the plasma membrane, and water reabsorption from the prourine.	Water	148-153	arginine vasopressin	Homo sapiens	11-22
24154696-1	2013	Binding of vasopressin to its type 2 receptor in renal collecting ducts induces cAMP signaling, transcription and translocation of aquaporin (AQP)2 water channels to the plasma membrane, and water reabsorption from the prourine.	Water	191-196	arginine vasopressin	Homo sapiens	11-22
23931556-3	2013	Utilizing FTIR and polarized-ATR spectroscopies, we determine the location of the chromium tricarbonyl motif to be situated at the water-membrane interface with an orientation of 46 +- 2  relative to the vector normal to the membrane surface.	Water	131-136	ATR serine/threonine kinase	Homo sapiens	29-32
24688730-3	2013	Using molecular dynamics simulations, MM/GBSA free energy calculations, hydrogen bond analysis, water characterization and umbrella sampling, we provide a complete atomistic picture of the binding between inlA and Ecad.	Water	96-101	cadherin 1	Mus musculus	214-218
24162131-2	2013	Here we use dielectric relaxation spectroscopy techniques to study the relaxation orientation dynamics of water entrapped in different polymeric matrices with pore sizes of the order of 100 mum, analyzing the frequency relaxation behaviour of the dielectric response.	Water	106-111	latexin	Homo sapiens	190-193
23939285-0	2013	Ternary self-assemblies in water: forming a pentanuclear ReLn4 assembly by association of binuclear lanthanide binding pockets with fac-Re(CO)3(dinicotinate)2Cl.	Water	27-32	FA complementation group C	Homo sapiens	132-135
24900792-4	2014	Our results highlight that structurally close analogs of this inhibitor series interact with FGFR1 with different binding modes, which are a consequence of conformational changes in both the protein and the ligand as well as the bound water network.	Water	235-240	fibroblast growth factor receptor 1	Homo sapiens	93-98
23942575-5	2013	The limit of detection was 0.1 muM for cocaine in purified water, and well defined results were also obtained in biological fluids and the specificity experiment, which expands the feasibility of the as-prepared sensor for practical applications.	Water	59-64	latexin	Homo sapiens	31-34
24106735-1	2013	Utilizing human serum albumin as a reducing plus stabilizing agent, fluorescent Au/Ag core/shell nanocrystals (NCs) were prepared in water at pH 9.0 and at physiological temperature (37  C).	Water	133-138	albumin	Homo sapiens	16-29
24224491-0	2013	Renewal of the air-water interface as a critical system parameter of protein stability: aggregation of the human growth hormone and its prevention by surface-active compounds.	Water	19-24	growth hormone 1	Homo sapiens	113-127
24224491-2	2013	The recombinant human growth hormone (rhGH) was recently shown to undergo aggregation into micrometer-sized solid particles composed of non-native (mis- or unfolded) protein, once its solutions were stirred or shaken to generate a continuously renewed air-water interface.	Water	256-261	growth hormone 1	Homo sapiens	22-36
23678852-6	2013	ALS patients showed a significant increase in intra- and extra-cellular water, indirectly linked to neuroinflammatory activity.	Water	72-77	superoxide dismutase 1	Homo sapiens	0-3
24228866-3	2013	This work uses the SPC/E water model and solutes based upon DFT calculations to examine both structural and thermodynamic properties of the dissociation processes.	Water	25-30	proline rich protein gene cluster	Homo sapiens	19-22
24124100-0	2013	Noble-metal-free NiS/C3 N4 for efficient photocatalytic hydrogen evolution from water.	Water	80-85	solute carrier family 5 member 5	Homo sapiens	17-20
23387971-6	2013	When compared to curcumin dissolved in DMSO, dendrimer-curcumin conjugate dissolved in water was significantly more effective in inducing cytotoxicity, as measured by the MTT assay and effectively induced cellular apoptosis measured by caspase-3 activation.	Water	87-92	caspase 3	Homo sapiens	236-245
24093781-14	2013	The expressions of TNF-alpha and ET-1 mRNA were also be inhibited by water extract of V. axillare.	Water	69-74	tumor necrosis factor	Rattus norvegicus	19-28
24093781-15	2013	CONCLUSION: Current evidences show water extract of V. axillare is effective for defending against ethanol-induced gastric mucosal lesions, significantly inhibiting the production of pro-inflammatory cytokines and the expressions of TNF-alpha and ET-1 mRNA, which may be useful for inhibiting apoptosis and improving local microcirculation.	Water	35-40	tumor necrosis factor	Rattus norvegicus	233-242
23850176-7	2013	Their Vmax values were markedly higher in the river water than in the seawater and their ratio suggested that most of the DOM used by microbes in the Arno River was polysaccharide-like, while in the seawater it was mainly protein-like.	Water	52-57	cytohesin 2	Homo sapiens	150-154
24345907-2	2013	Following osmotic stress such as dehydration, this tissue undergoes morphological, electrical and transcriptional changes to facilitate the appropriate regulation and release of Avp into the circulation where it conserves water at the level of the kidney.	Water	222-227	arginine vasopressin	Homo sapiens	178-181
23811973-8	2013	Restricted water diffusion correlated with epidermal growth factor receptor amplification (P = .04), whereas the other 7 morphologic MR imaging signs did not (P &gt; .12).	Water	11-16	epidermal growth factor receptor	Homo sapiens	43-75
24076743-6	2013	In particular, a detailed analysis of water molecules at the interfaces of high-resolution (&lt;=2.30 A) X-ray crystal structures of protein-protein complexes, where 140 are biological protein-protein complex structures and 112 include non-biological protein-protein interfaces, was carried out using modeling tools based on the HINT forcefield.	Water	38-43	histidine triad nucleotide binding protein 1	Homo sapiens	329-333
23584881-2	2013	Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2).	Water	0-5	arginine vasopressin	Homo sapiens	36-47
23584881-2	2013	Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2).	Water	74-79	arginine vasopressin	Homo sapiens	36-47
23584881-5	2013	Here we review vasopressin signaling in the renal collecting duct that is relevant to the two modes of water permeability regulation.	Water	103-108	arginine vasopressin	Homo sapiens	15-26
24138109-3	2013	Herein, bovine serum albumin was readily encapsulated onto alkyl-terminated PSiNPs surfaces via hydrophobic interaction, which could significantly improve their water-dispersibility and long-term stability under physiological conditions.	Water	161-166	albumin	Homo sapiens	15-28
24149441-7	2013	Faecal water increased TER independent of dietary intervention, indicating that commensal bacteria produce metabolites that generally provide a positive effect on intestinal integrity.	Water	7-12	trans-2,3-enoyl-CoA reductase	Homo sapiens	23-26
24169407-4	2013	Both corticosteroids and vitamin A derivatives have been shown to upregulate the expression of aquaporin 1, a water channel protein.	Water	110-115	aquaporin 1 (Colton blood group)	Homo sapiens	95-106
24169407-5	2013	Aquaporin 1 is widely distributed in the human brain and is associated with water secretion into the subarachnoid space.	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
23832232-11	2013	This methodology has been applied for the determination of Pb(II) in water samples with good results.	Water	69-74	submaxillary gland androgen regulated protein 3B	Homo sapiens	59-65
23593642-1	2013	PURPOSE: This study evaluated the effect of residual water included within the FT-IR spectra on the calculation of the degree of conversion (DC) of a self-etching adhesive (SEA).	Water	53-58	chemokine (C-C motif) ligand 22	Mus musculus	141-143
23593642-7	2013	However, the agitation time did not affect the aDC or the difference between the mDC and the aDC, except at 20 s. CONCLUSION: When the DC of SEA itself is measured with FT-IR, the mDC needs to be adjusted with the water subtraction algorithm.	Water	214-219	chemokine (C-C motif) ligand 22	Mus musculus	180-183
24106805-2	2013	The present constant-pH MD study of the acylated and deacylated isoforms of SP-C in a chloroform/methanol/water mixture, often used to mimic the membrane environment, shows that the loss of the acyl groups has a structural destabilizing effect and that the increase of pH promotes intraprotein contacts which contribute to the loss of helical structure in solution.	Water	106-111	surfactant protein C	Homo sapiens	76-80
23813972-8	2013	Localization of AQP1 and SLC4A11 in human and murine corneal (apical and basolateral, respectively) suggests a cooperative role in mediating trans-endothelial water reabsorption.	Water	159-164	aquaporin 1 (Colton blood group)	Homo sapiens	16-20
24199833-2	2013	The complexes were synthesized through the corresponding fac-[M(CO)3(H2O)(OO)] (M = Re, (99m)Tc) intermediate aqua complex.	Water	69-72	FA complementation group C	Homo sapiens	57-60
24199833-3	2013	In the presence of phosphine, replacement of the H2O molecule of the intermediate complex at room temperature generates the neutral tricarbonyl monophosphine fac-[Re(CO)3(P)(OO)] complex, while under reflux conditions further replacement of the trans to the phosphine carbonyl generates the new stable dicarbonyl bisphosphine complex cis-trans-[Re(CO)2(P)2(OO)].	Water	49-52	FA complementation group C	Homo sapiens	158-161
24219057-3	2013	Here we show that the coarse-grained model for water called WatFour (WT4) can be combined with any of the three most used water models for atomistic simulations (SPC, TIP3P, and SPC/E) without modifying the characteristics of the atomistic solvent and solutes.	Water	47-52	WT4	Homo sapiens	69-72
23981337-1	2013	Etoposide is recognized as a dual P-glycoprotein (P-gp) and cytochrome P450 3A (CYP3A) substrate drug with poor water-solubility.	Water	112-117	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	80-85
24199617-5	2013	A normalized rate of hydrate formation of 64.48 (+-3.82) mol x min(-1) x m(-3) was obtained at 6.0 MPa and 274.2 K. Based on a morphological study, the mechanism of hydrate formation from water dispersed in interstitial pore space of the porous medium is presented.	Water	188-193	CD59 molecule (CD59 blood group)	Homo sapiens	63-69
24117248-2	2013	Water-dispersible Ag2S quantum dots (QDs) were synthesized via a one-pot procedure using reduced glutathiose (GSH) as both sulfur source and stabilizer.	Water	0-5	angiotensin II receptor, type 1a	Mus musculus	18-22
24511695-3	2013	Human consumption of water with elevated levels of NO3-N has been linked to the infant disorder methemoglobinemia and also to non-Hodgkin"s disease lymphoma in adults.	Water	21-26	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
23948641-0	2013	AQP1 expression alterations affect morphology and water transport in Schwann cells and hypoxia-induced up-regulation of AQP1 occurs in a HIF-1alpha-dependent manner.	Water	50-55	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
24134052-1	2013	The diphtheria toxin translocation domain (T-domain) and the apoptotic repressor Bcl-xL are membrane proteins that adopt their final topology by switching folds from a water-soluble to a membrane-inserted state.	Water	168-173	BCL2 like 1	Homo sapiens	81-87
23994596-0	2013	Brain regions influenced by the lateral parabrachial nucleus in angiotensin II-induced water intake.	Water	87-92	angiotensinogen	Rattus norvegicus	64-78
23994596-7	2013	These data suggest that the direct effects of LPBN lesions caused an increase in AngII-induced water intake and in rats that did not drink an increase in Fos expression, while indirect secondary effects of LPBN lesions caused a reduction in Fos expression possibly related to excessive ingestion of water.	Water	95-100	angiotensinogen	Rattus norvegicus	81-86
23948641-1	2013	Aquaporin-1 (AQP1) is the principle water channel in the peripheral nervous system (PNS) and is specifically localized to Schwann cells in the PNS.	Water	36-41	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
23948641-1	2013	Aquaporin-1 (AQP1) is the principle water channel in the peripheral nervous system (PNS) and is specifically localized to Schwann cells in the PNS.	Water	36-41	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
23948641-8	2013	Taken together, these results indicate that (1) AQP1 is an important factor responsible for the fast water transport of cultured Schwann cells and is involved in cell plasticity; (2) AQP1 alterations may be a primary factor in hypoxia-induced peripheral nerve edema; (3) HIF-1alpha participates in the hypoxic induction of the AQP1 gene; (4) AQP1 inhibition might provide a new therapeutic alternative for the treatment of some forms of peripheral nerve edema.	Water	101-106	aquaporin 1 (Colton blood group)	Homo sapiens	48-52
23765701-11	2013	Upregulation of CFTR and enhanced Cl(-) efflux after ambroxol treatment should promote transepithelial ion and water transport, which may improve hydration of the mucus, and therefore be beneficial to CF-patients.	Water	111-116	CF transmembrane conductance regulator	Homo sapiens	16-20
24127683-0	2013	Water-soluble Co(III) complexes of substituted phenanthrolines with cell selective anticancer activity.	Water	0-5	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	14-21
24127683-2	2013	Here, we report the synthesis and cell selective anticancer activity of five new water-soluble Co(III) complexes with methyl substituted phenanthroline ligands.	Water	81-86	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	95-102
24121432-4	2013	The best conditions were achieved when a PDMS/DVB 65 mum fibre was exposed for 45 min in the headspace of 10 mL water samples at 100  C. Method detection limits were found in the low ng L-1 range between 0.75 and 5 ng L-1 depending on the target analytes.	Water	112-117	immunoglobulin kappa variable 1-16	Homo sapiens	186-189
24260356-1	2013	Aquaporin 3 (AQP3) is an aquaglyceroporin which transports water, glycerol and small solutes across the plasma membrane.	Water	59-64	aquaporin 3	Mus musculus	0-11
24260356-1	2013	Aquaporin 3 (AQP3) is an aquaglyceroporin which transports water, glycerol and small solutes across the plasma membrane.	Water	59-64	aquaporin 3	Mus musculus	13-17
24100222-9	2013	Recent studies have demonstrated that perturbations in corin activity lead to elevation of the prohormones at the expense of the mature forms, thereby causing the development of salt-sensitive hypertension, preeclampsia, cardiac hypertrophy, and Na and water retention.	Water	253-258	corin, serine peptidase	Homo sapiens	55-60
23974165-0	2013	Sediment pore water distribution coefficients of PCB congeners in enriched black carbon sediment.	Water	14-19	pyruvate carboxylase	Homo sapiens	49-52
23955305-2	2013	Using real-time RT-PCR, we tested the assumption that renal HA may be involved in the long-term effect of vasopressin on water reabsorption.	Water	121-126	arginine vasopressin	Rattus norvegicus	106-117
24072408-9	2013	Accumulations of microglia around the third ventricle and increases in TNF-alpha in the CSF were observed in rats that drank water at a rapid rate; these were not seen in rats that drank water slowly.	Water	125-130	tumor necrosis factor	Rattus norvegicus	71-80
24120416-1	2013	Aquaporin 0 (AQP0) performs dual functions in the lens fiber cells, as a water pore and as a cell-to-cell adhesion molecule.	Water	73-78	major intrinsic protein of lens fiber	Homo sapiens	0-11
24120416-1	2013	Aquaporin 0 (AQP0) performs dual functions in the lens fiber cells, as a water pore and as a cell-to-cell adhesion molecule.	Water	73-78	major intrinsic protein of lens fiber	Homo sapiens	13-17
23843128-4	2013	While we did find increased N mineralization rates under both global change scenarios, water addition also significantly increased net nitrification rates, loss of NO3 (-) -N via leaching, and lowered rates of labile organic N production.	Water	87-92	NBL1, DAN family BMP antagonist	Homo sapiens	164-167
24307926-3	2013	Upregulation of serine protease activity causes adverse structural changes of the stratum corneum due to degradation of certain stratum corneum proteins that are integral to epidermal structure and functions, interference with the formation of the stratum corneum intercellular lipid membrane, which normally regulates epidermal water flux and gradient, and induction of a TH2 pattern of inflammation, which is the hallmark profile of atopic skin.	Water	329-334	coagulation factor II, thrombin	Homo sapiens	16-31
24276616-5	2013	In this study, we computationally analyzed the role of this water molecule as a putative hydrogen bond donor/acceptor moiety in the agonist binding site of the three most relevant heteromeric (alpha4beta2, alpha3beta4) and homomeric (alpha7) neuronal nicotinic acetylcholine receptor (nAChR) subtypes.	Water	60-65	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	285-290
23955305-9	2013	It is suggested that vasopressin is able to inhibit the synthesis of HA and concomitantly promote its degradation in the interstitium of the renal papilla, thereby facilitating water flow between elements of the renal countercurrent system.	Water	177-182	arginine vasopressin	Rattus norvegicus	21-32
24121352-3	2013	A globular protein, lysozyme, adsorbed at the air-water interface is found to unfold into a flat shape within 1 s.	Water	50-55	lysozyme	Homo sapiens	20-28
23830368-2	2013	Aquaporin 8 (AQP8) can modulate water transport and osmotic swelling of mitochondria in the inner mitochondrial membrane of the liver.	Water	32-37	aquaporin 8	Rattus norvegicus	0-11
23830368-2	2013	Aquaporin 8 (AQP8) can modulate water transport and osmotic swelling of mitochondria in the inner mitochondrial membrane of the liver.	Water	32-37	aquaporin 8	Rattus norvegicus	13-17
24111489-4	2013	The first is a water-assisted proton transfer within proteasome, activating Thr1-O(gamma).	Water	15-20	thyroid hormone receptor beta	Homo sapiens	76-80
24320412-10	2013	RESULTS: Beam transport calculations show that a pair of electromagnetic quadrupoles can be used to create a divergent fan beam of 200 MeV protons over a distance of 2.1 m. The quadrupole lengths were 30 and 48 cm, respectively, with transverse field gradients less than 20 T/m, which is within the range of water-cooled magnets for the quadrupole radii used.	Water	308-313	neutral sphingomyelinase activation associated factor	Homo sapiens	119-122
24121341-5	2013	Through these water molecules, the bound ANS molecule forms indirect hydrogen-bond interactions with FABP3.	Water	14-19	fatty acid binding protein 3	Homo sapiens	101-106
24111489-6	2013	The fourth step is a nucleophilic attack on the carbonyl carbon of the Tyr residue of substrate by a water molecule, accompanied by a proton transfer from the water molecule to Thr1-N(z).	Water	101-106	thyroid hormone receptor beta	Homo sapiens	177-181
24111489-6	2013	The fourth step is a nucleophilic attack on the carbonyl carbon of the Tyr residue of substrate by a water molecule, accompanied by a proton transfer from the water molecule to Thr1-N(z).	Water	159-164	thyroid hormone receptor beta	Homo sapiens	177-181
24090437-3	2013	In the ternary systems with the insulin-enhancing compounds, mixed species are observed with Hma, Hdhp, and Hpic with the formation of VOL2(holo-hTf), explained through the interaction of cis-[VOL2(H2O)] (L = ma, dhp) or cis-[VOL2(OH)](-) (L = pic) with an accessible His residue that replaces the monodentate H2O or OH(-) ligand.	Water	198-201	insulin	Homo sapiens	32-39
23895249-1	2013	Fog represents a large untapped source of potable water, especially in arid climates.	Water	50-55	zinc finger protein, FOG family member 1	Homo sapiens	0-3
24168327-8	2013	CONCLUSIONS: These results implicate HSI2 as a negative regulator of drought stress response in Arabidopsis, acting, at least in part, by regulating transpirational water loss.	Water	165-170	B3 domain-containing transcription repressor VAL1	Arabidopsis thaliana	37-41
24090437-3	2013	In the ternary systems with the insulin-enhancing compounds, mixed species are observed with Hma, Hdhp, and Hpic with the formation of VOL2(holo-hTf), explained through the interaction of cis-[VOL2(H2O)] (L = ma, dhp) or cis-[VOL2(OH)](-) (L = pic) with an accessible His residue that replaces the monodentate H2O or OH(-) ligand.	Water	310-313	insulin	Homo sapiens	32-39
23946287-8	2013	In contrast to changes in oral salt intake, water restriction (48 h) and water loading (8% sucrose solution) increased and suppressed the expression of all NKCC2 isoforms, without changing the distribution pattern of the single isoforms.	Water	44-49	solute carrier family 12, member 1	Mus musculus	156-161
23946287-8	2013	In contrast to changes in oral salt intake, water restriction (48 h) and water loading (8% sucrose solution) increased and suppressed the expression of all NKCC2 isoforms, without changing the distribution pattern of the single isoforms.	Water	73-78	solute carrier family 12, member 1	Mus musculus	156-161
24004194-6	2013	A kinetic model of IEPOX and MAE loss showed that MAE forms 10-100 times more ring-opening products than IEPOX and that both are strongly dependent on aerosol water content when aerosol pH is constant.	Water	159-164	solute carrier family 6 member 1	Homo sapiens	50-53
23987469-1	2013	A water-soluble polysaccharide (FAAP-02), composed of N-acetyl-D-glucosamine, glucose, mannose, galactose, rhamnose, arabinose, xylose and ribose, with an average molecular weight of 5169 Da, was isolated from Artemisia argyi.	Water	2-7	RNA 2',3'-cyclic phosphate and 5'-OH ligase	Mus musculus	32-36
24055755-7	2013	In TBT-exposed zebrafish embryos, ectopic expression of the gene encoding zebrafish homolog of the 78 kDa glucose-regulating protein (GRP78) and gene encoding CCAAT/enhancer-binding protein homologous protein (CHOP) was detected in the precursors of the neuromast, which is a sensory organ for detecting water flow and vibration.	Water	304-309	DNA-damage-inducible transcript 3	Danio rerio	159-208
23928483-7	2013	Domains with different shapes in C18-l-Glu and C18-d-Glu monolayers were observed under a fluorescence microscope in situ at the air/water interface.	Water	133-138	Bardet-Biedl syndrome 9	Homo sapiens	33-36
23908318-1	2013	The purpose of this study was to examine the effect of beta-hydroxy-beta-methylbutyrate-free acid (HMB-FA) and cold-water immersion (CWI) on circulating concentrations of TNF-alpha and monocyte TNF-alpha receptor 1 (TNFR1) expression.	Water	116-121	tumor necrosis factor	Homo sapiens	171-180
23928483-7	2013	Domains with different shapes in C18-l-Glu and C18-d-Glu monolayers were observed under a fluorescence microscope in situ at the air/water interface.	Water	133-138	Bardet-Biedl syndrome 9	Homo sapiens	47-50
23928483-8	2013	Herein, we present a mechanism for C18-l-Glu and C18-d-Glu interacting with l-arginine at the air/water interface.	Water	98-103	Bardet-Biedl syndrome 9	Homo sapiens	35-38
23928483-8	2013	Herein, we present a mechanism for C18-l-Glu and C18-d-Glu interacting with l-arginine at the air/water interface.	Water	98-103	Bardet-Biedl syndrome 9	Homo sapiens	49-52
23953088-1	2013	The UV-filter BP-4 (2-hydroxy-4-methoxybenzophenone-5-sulfonic acid) has been frequently observed in the environment, showing high potentials to invade drinking water, swimming water, or wastewater reclamation treatment systems.	Water	161-166	BP4	Homo sapiens	14-18
24011723-3	2013	Assays performed on 25mL of ultra-pure water samples spiked at the 8.0mug/L level, yielded recoveries ranging from 76.6+-8.3% to 103.5+-6.4% depending on the sorbent phase used (P2 or AC4), under optimized experimental conditions.	Water	39-44	adenylate cyclase 4	Homo sapiens	184-187
23958801-2	2013	Water was modeled with the extended simple point charge potential (SPC/E).	Water	0-5	proline rich protein gene cluster	Homo sapiens	67-70
23917332-4	2013	In treatment with 400 mL portions of water samples containing 30 mug L(-1) As(V), the relative standard deviation was 2.8%.	Water	37-42	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	75-80
23966318-3	2013	We previously showed that an increase in the permeability of the plasma membrane in mouse oocytes to water and cryoprotectants, caused by the artificial expression of aquaporin 3, an aquaglyceroporin, enhanced tolerance to cryopreservation.	Water	101-106	aquaporin 3	Mus musculus	167-178
24112444-0	2013	Does continuous endurance exercise in water elicit a higher release of ANP and BNP and a higher plasma concentration of FFAs in pre-obese and obese men than high intensity intermittent endurance exercise?	Water	38-43	natriuretic peptide A	Homo sapiens	71-74
24112444-6	2013	The combined effects of endurance exercise and water immersion on ANP and FFA plasma concentration and the magnitude of excess post-exercise oxygen consumption (EPOC) might be further enhanced by choosing the most effective exercise protocol.	Water	47-52	natriuretic peptide A	Homo sapiens	66-69
24112444-13	2013	The aims of the study are to investigate (1) whether continuous endurance exercise or high intensity intermittent endurance exercise in water elicits both a higher release of ANP and BNP and a higher plasma concentration of glycerol and (2) to determine whether continuous endurance exercise in water or a high intensity intermittent endurance exercise in water would lead to a more pronounced short term (two hours) EPOC effect.	Water	136-141	natriuretic peptide A	Homo sapiens	175-178
24112444-14	2013	DISCUSSION: If our hypothesis would be confirmed, the most effective exercise protocol based on the combined effects of high intensity endurance exercise and water immersion on ANP and BNP release and glycerol plasma concentrations can be identified.	Water	158-163	natriuretic peptide A	Homo sapiens	177-180
23939252-0	2013	Voltammetric and spectroscopic characterization of early intermediates in the Co(II)-polypyridyl-catalyzed reduction of water.	Water	120-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
23526806-10	2013	It is concluded that a higher water content of SAMs formed by enantiopure PGMA(S) and PGMA(R) SAMs arises from the macromolecular chiral conformation adopted by their enantiopure PGMA chains, and it is the decisive reason for the reduced BSA adsorption and cell adhesion as compared to PGMA(rac) SAMs.	Water	30-35	AKT serine/threonine kinase 1	Homo sapiens	291-294
23972471-3	2013	Crystal structures of the GluN1 and GluN3A ligand-binding domains (LBDs) in their apo states unexpectedly reveal open- and closed-cleft conformations, respectively, with water molecules filling the binding pockets.	Water	170-175	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	26-31
32261163-0	2013	Albumin-mediated incorporation of water-insoluble therapeutics in layer-by-layer assembled thin films and microcapsules.	Water	34-39	albumin	Homo sapiens	0-7
32261163-2	2013	The hydrophobic molecule binding properties of albumin have been exploited for solubilization of a water-insoluble molecule, pyrene (model drug), by preparation of non-covalent conjugates with bovine serum albumin (BSA).	Water	99-104	albumin	Homo sapiens	47-54
32261163-2	2013	The hydrophobic molecule binding properties of albumin have been exploited for solubilization of a water-insoluble molecule, pyrene (model drug), by preparation of non-covalent conjugates with bovine serum albumin (BSA).	Water	99-104	albumin	Homo sapiens	200-213
23868847-5	2013	All three Aqp8 paralogs were permeable to water and urea, whereas Aqp8ab and -8b were, surprisingly, also permeable to glycerol.	Water	42-47	aquaporin-8	Salmo salar	10-14
23868847-10	2013	These data indicate that the Atlantic salmon Aqp8 paralogs have neofunctionalized on a transcriptional as well as a functional level, and that Aqp8ab may play a central role in the intestinal transcellular uptake of water during SW acclimation.	Water	216-221	aquaporin-8	Salmo salar	45-49
24116578-1	2013	A simple set of equations is proposed to govern the relations between the thermodynamic potentials in rigid, apolar wall-water systems, which is found to be consistent with the data for two systems: alkane plate-SPC/E water [R. Zangi and B. J. Berne, J. Phys.	Water	121-126	proline rich protein gene cluster	Homo sapiens	212-215
23974296-3	2013	We observed the ability of the water-soluble murine amylin to aggregate in water resulting in an insoluble material with Thioflavin T binding properties.	Water	31-36	islet amyloid polypeptide	Mus musculus	52-58
23986358-5	2013	The collecting duct produces large amounts of ET-1 that bind in an autocrine manner to endothelin A and B receptors, causing inhibition of Na(+) and water reabsorption; absence of collecting duct ET-1 or its receptors is associated with marked salt-sensitive hypertension.	Water	149-154	endothelin 1	Homo sapiens	46-50
23986358-5	2013	The collecting duct produces large amounts of ET-1 that bind in an autocrine manner to endothelin A and B receptors, causing inhibition of Na(+) and water reabsorption; absence of collecting duct ET-1 or its receptors is associated with marked salt-sensitive hypertension.	Water	149-154	endothelin receptor type B	Homo sapiens	87-115
23986358-6	2013	Collecting duct ET-1 production is stimulated by Na(+) and water loading through local mechanisms that include sensing of salt and other solute delivery as well as shear stress.	Water	59-64	endothelin 1	Homo sapiens	16-20
23883678-4	2013	Vasopressin secretion and thirst are stimulated by increases in the osmolality of the extracellular fluid as well as decreases in blood pressure and/or blood volume, signals that are precipitated by water depletion associated with the excess evaporative water loss required to prevent hyperthermia.	Water	199-204	arginine vasopressin	Homo sapiens	0-11
23883678-4	2013	Vasopressin secretion and thirst are stimulated by increases in the osmolality of the extracellular fluid as well as decreases in blood pressure and/or blood volume, signals that are precipitated by water depletion associated with the excess evaporative water loss required to prevent hyperthermia.	Water	254-259	arginine vasopressin	Homo sapiens	0-11
23885061-5	2013	Parathyroid hormone-related protein (PTHrP), whose cognate receptor underwent a gene duplication during the transition from fish to amphibians, facilitated gas exchange for the water-to-land transition, since PTHrP is necessary for the formation of lung alveoli: deletion of the PTHrP gene in mice causes the offspring to die within a few minutes of birth due to the absence of alveoli.	Water	177-182	parathyroid hormone-like peptide	Mus musculus	37-42
23885061-5	2013	Parathyroid hormone-related protein (PTHrP), whose cognate receptor underwent a gene duplication during the transition from fish to amphibians, facilitated gas exchange for the water-to-land transition, since PTHrP is necessary for the formation of lung alveoli: deletion of the PTHrP gene in mice causes the offspring to die within a few minutes of birth due to the absence of alveoli.	Water	177-182	parathyroid hormone-like peptide	Mus musculus	209-214
23885061-5	2013	Parathyroid hormone-related protein (PTHrP), whose cognate receptor underwent a gene duplication during the transition from fish to amphibians, facilitated gas exchange for the water-to-land transition, since PTHrP is necessary for the formation of lung alveoli: deletion of the PTHrP gene in mice causes the offspring to die within a few minutes of birth due to the absence of alveoli.	Water	177-182	parathyroid hormone-like peptide	Mus musculus	209-214
23816441-7	2013	Furthermore, the interaction of these membrane proteins with water-soluble proteins, like cytochrome c or hydrogenase, is studied on the molecular level by SEIRAS.	Water	61-66	cytochrome c, somatic	Homo sapiens	90-102
23881359-0	2013	Study on the interaction between a water-soluble dinuclear nickel complex and bovine serum albumin by spectroscopic techniques.	Water	35-40	albumin	Homo sapiens	85-98
23974296-3	2013	We observed the ability of the water-soluble murine amylin to aggregate in water resulting in an insoluble material with Thioflavin T binding properties.	Water	75-80	islet amyloid polypeptide	Mus musculus	52-58
24079737-4	2013	Occlusion with a water-impermeable plastic membrane partially blocked the increases in cortisol secretion and CYP11B1 and IL-1beta mRNA expression in the dry condition.	Water	17-22	interleukin 1 beta	Homo sapiens	122-130
23746367-3	2013	Nonylphenol (NP), octylphenol (OP), and bisphenol A (BPA) were identified as the main xenoestrogens ranging from tens of ngL(-1) (in the surface water) or ng g(-1)dw (in the suspended particles and sediment) to tens of mugL(-1) or mug g(-1)dw.	Water	145-150	leucine rich repeat containing 4C	Homo sapiens	121-127
24156710-5	2013	METHODS: Molecular genetic testing of the AVP gene was proceeded, because of the inconclusive results of water deprivation test consistent with partial diabetes insipidus, missing "bright spot" of posterior pituitary gland in T1-weighted magnetic resonance imaging and family occurrence of polyuria and polydipsia on anamnestic evaluation.	Water	105-110	arginine vasopressin	Homo sapiens	42-45
23917810-3	2013	Aldosterone, the final product of the renin-angiotensin-aldosterone system (RAAS), not only causes salt and water reabsorbtion in the kidneys through its effect on the mineralocorticoid hormone receptor (MR), but also an MR-independent effect, not regulated by conventional MR blockade.	Water	108-113	renin	Homo sapiens	38-43
24020636-0	2013	Analysis of the activation of acetylcholinesterase by carbon nanoparticles using a monolithic immobilized enzyme microreactor: role of the water molecules in the active site gorge.	Water	139-144	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-50
23747619-3	2013	The aim of this work was to test the feasibility of NIR interactance imaging for on-line analysis of water, fat and salt and their spatial distribution in dry-cured ham slices.	Water	101-106	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	52-55
23747619-4	2013	PLSR models for predicting water, fat and salt contents with NIR spectra were developed with a calibration set of samples (n=82).	Water	27-32	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	61-64
23863845-6	2013	Contrary to our previously studied wild-type (wt) p53-DNA complexes showing non-canonical Hoogsteen A/T base pairs of the DNA helix that lead to local minor-groove narrowing and enhanced electrostatic interactions with p53, the current structures display Watson-Crick base pairs associated with direct or water-mediated hydrogen bonds with p53 at the minor groove.	Water	305-310	tumor protein p53	Homo sapiens	50-53
23872246-3	2013	Further, DBP exposure through dermal contact during showering is estimated using steady-state condition between the DBPs in shower water impacting on human skin and skin exposed to shower water.	Water	131-136	D-box binding PAR bZIP transcription factor	Homo sapiens	9-12
23957745-7	2013	Each agonist suppressed AngII-induced water intake; however, only exendin-4 suppressed saline intake.	Water	38-43	angiotensinogen	Rattus norvegicus	24-29
23939808-1	2013	Taking advantage of photothermal conversion, the surface pores of water-dispersible single-walled carbon nanotubes assembled on polymer particles were rapidly closed by NIR irradiation to produce macroporous polymeric microspheres with multiple interconnected chambers.	Water	66-71	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	169-172
23820008-10	2013	In contrast, SN and SF contributed more NO3- to water in May than that in December.	Water	48-53	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
23810862-3	2013	Under typical surface-water conditions, direct photolysis and reactions with ( )OH and (3)CDOM* would be the main processes of BP3 phototransformation.	Water	22-27	BP3	Homo sapiens	127-130
23820008-4	2013	The highest NO3- concentration in water was in May (wet season, mean+-SD=17.45+-9.50 mg L(-1)) and the lowest concentration occurred in December (dry season, mean+-SD=10.54+-6.28 mg L(-1)).	Water	34-39	NBL1, DAN family BMP antagonist	Homo sapiens	12-15
23947824-15	2013	We fit the gCP scheme for a recently developed pob-TZVP solid-state basis set and obtain reasonable results for the X23 benchmark set and the potential energy curve for water adsorption on a nickel (110) surface.	Water	169-174	golgin B1	Homo sapiens	11-14
23935101-1	2013	The vasopressin type 2 receptor (V2R) is a critical G protein-coupled receptor (GPCR) for vertebrate physiology, including the balance of water and sodium ions.	Water	138-143	arginine vasopressin receptor 2	Homo sapiens	4-36
23935101-7	2013	We propose that this mechanism explains how VP sustains water and Na(+) transport in renal collecting duct cells.	Water	56-61	arginine vasopressin	Homo sapiens	44-46
23895735-4	2013	Ten of 13 samples of source water exhibited detectable AR antagonistic potencies with AR antagonist equivalents (Ant-AR-EQs) ranging from &lt;15.3 (detection limit) to 140 mug flutamide/L.	Water	28-33	androgen receptor	Homo sapiens	55-57
24086369-3	2013	We hypothesized that seronegative NMOsd patients might have autoantibodies against aquaporin-1 (AQP1), another water channel in CNS astrocytes.	Water	111-116	aquaporin 1 (Colton blood group)	Homo sapiens	83-94
24086369-3	2013	We hypothesized that seronegative NMOsd patients might have autoantibodies against aquaporin-1 (AQP1), another water channel in CNS astrocytes.	Water	111-116	aquaporin 1 (Colton blood group)	Homo sapiens	96-100
24086508-6	2013	To further pinpoint the cellular and molecular mechanism of AC, we studied the dose response of a human monocytic cell line, THP-1, to the whole water extract of AC.	Water	145-150	GLI family zinc finger 2	Homo sapiens	125-130
23895735-4	2013	Ten of 13 samples of source water exhibited detectable AR antagonistic potencies with AR antagonist equivalents (Ant-AR-EQs) ranging from &lt;15.3 (detection limit) to 140 mug flutamide/L.	Water	28-33	androgen receptor	Homo sapiens	86-88
23895735-4	2013	Ten of 13 samples of source water exhibited detectable AR antagonistic potencies with AR antagonist equivalents (Ant-AR-EQs) ranging from &lt;15.3 (detection limit) to 140 mug flutamide/L.	Water	28-33	androgen receptor	Homo sapiens	86-88
24004419-4	2013	Predominantly monomeric Abeta40 exerts toxicity toward SH-SY5Y cells and has been shown to insert spontaneously into anionic lipid monolayers at the air/water interface, resulting in the misfolding and assembly of Abeta into beta-sheet-enriched oligomers.	Water	153-158	amyloid beta precursor protein	Homo sapiens	24-29
23895735-7	2013	Although potential risks are posed by source water, water treatment processes effectively removed AR antagonists.	Water	52-57	androgen receptor	Homo sapiens	98-100
23878362-6	2013	ENaC is negatively regulated by CFTR and, in patients with CF, the absence of CFTR results in a double hit of reduced Cl-/HCO3- and H2O secretion as well as ENaC hyperactivity and increased Na+ and H2O absorption.	Water	198-201	CF transmembrane conductance regulator	Homo sapiens	32-36
23906473-3	2013	The results indicate that the desorption kinetics highly depends on the PE-water partition coefficients of PCB congeners.	Water	75-80	pyruvate carboxylase	Homo sapiens	107-110
23878362-6	2013	ENaC is negatively regulated by CFTR and, in patients with CF, the absence of CFTR results in a double hit of reduced Cl-/HCO3- and H2O secretion as well as ENaC hyperactivity and increased Na+ and H2O absorption.	Water	198-201	CF transmembrane conductance regulator	Homo sapiens	78-82
23878362-6	2013	ENaC is negatively regulated by CFTR and, in patients with CF, the absence of CFTR results in a double hit of reduced Cl-/HCO3- and H2O secretion as well as ENaC hyperactivity and increased Na+ and H2O absorption.	Water	132-135	CF transmembrane conductance regulator	Homo sapiens	32-36
23878362-6	2013	ENaC is negatively regulated by CFTR and, in patients with CF, the absence of CFTR results in a double hit of reduced Cl-/HCO3- and H2O secretion as well as ENaC hyperactivity and increased Na+ and H2O absorption.	Water	132-135	CF transmembrane conductance regulator	Homo sapiens	78-82
23954658-7	2013	Unfortunately, NO2(-) and NO3(-) could be observed in purified or deionized water.	Water	76-81	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
23866154-8	2013	Source waters with higher dissolved organic carbon levels induced increased DBP formation and caused greater effects in the endpoints related to DNA damage repair, glutathione conjugation/protein damage and the Nrf2 oxidative stress response pathway after disinfection.	Water	7-13	NFE2 like bZIP transcription factor 2	Homo sapiens	211-215
23842534-0	2013	Two novel Co(II) coordination polymers based on 1,4-bis(3-pyridylaminomethyl)benzene as electrocatalysts for oxygen evolution from water.	Water	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
23850797-9	2013	Seven days of angII infusion caused an increase in blood pressure and heart/body weight index and 28days of angII infusion also increased water intake in comparison with controls.	Water	138-143	angiotensinogen	Rattus norvegicus	108-113
23958587-3	2013	The nanotubes synthesized when an appropriate amount of water vapor was introduced had an average diameter of about 80 nm and lengths of several hundred mum.	Water	56-61	latexin	Homo sapiens	153-156
23944251-4	2013	Investigating AtO(+) clustered with an increasing number of water molecules and using various flavors of relativistic quantum methods, we found that AtO(+) adopts in solution a Kramers restricted closed-shell configuration resembling a scalar-relativistic singlet.	Water	60-65	splicing factor-like protein	Arabidopsis thaliana	149-152
24078591-1	2013	Random-acceleration molecular-dynamics (RAMD) simulations with models of homodimeric 6-ligated distal-NO and 5-ligated proximal-NO cytochrome c" complexes, in TIP3 H2 O, showed two distinct, non-intercommunicating worlds.	Water	164-168	cytochrome c, somatic	Homo sapiens	131-143
24015756-6	2013	This evidence for the positive selection of AQP2 and SLC14A2 suggests that the adaptive evolution of these genes has helped to enhance the capacity for water and urea transport, thereby leading to the concentration of urine, which is an efficient mechanism for maintaining the water balance.	Water	152-157	solute carrier family 14 member 2	Homo sapiens	53-60
24015756-7	2013	By contrast, a series of positively selected amino acid residues identified in the ACE and AGT (two key members of the renin-angiotensin-aldosterone system, RAAS) proteins of cetaceans suggests that RAAS might have been adapted to maintain the water and salt balance in response to a hyperosmotic environment.	Water	244-249	angiotensin I converting enzyme	Homo sapiens	83-86
24015756-7	2013	By contrast, a series of positively selected amino acid residues identified in the ACE and AGT (two key members of the renin-angiotensin-aldosterone system, RAAS) proteins of cetaceans suggests that RAAS might have been adapted to maintain the water and salt balance in response to a hyperosmotic environment.	Water	244-249	angiotensinogen	Homo sapiens	91-94
24015756-7	2013	By contrast, a series of positively selected amino acid residues identified in the ACE and AGT (two key members of the renin-angiotensin-aldosterone system, RAAS) proteins of cetaceans suggests that RAAS might have been adapted to maintain the water and salt balance in response to a hyperosmotic environment.	Water	244-249	angiotensinogen	Homo sapiens	119-155
24036859-6	2013	DIF was estimated at different depths in a water phantom.	Water	43-48	tumor necrosis factor	Homo sapiens	0-3
23937546-3	2013	In this paper, we investigate the nucleation of ice in nanoscale water films using molecular dynamics simulations.	Water	65-70	carboxylesterase 2	Homo sapiens	48-51
23866010-6	2013	Considering the results obtained in this study, biofilm needs to be considered an important precursor to DBP formation and biofilm eradication methods for water distribution systems need to be carefully selected to minimize subsequent DBP formation.	Water	155-160	D-box binding PAR bZIP transcription factor	Homo sapiens	235-238
23849206-0	2013	One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.	Water	142-147	poly(ADP-ribose) polymerase 1	Homo sapiens	169-174
23797335-2	2013	In eels, Ang II acts on the area postrema, a sensory circumventricular organ (CVO) and elicits water intake but other sensory CVOs have not yet been found in the eel forebrain.	Water	95-100	angiotensinogen	Homo sapiens	9-15
23608990-0	2013	Removal of Pb(II) from water using keratin colloidal solution obtained from wool.	Water	23-28	submaxillary gland androgen regulated protein 3B	Homo sapiens	11-17
23596182-10	2013	Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P &lt; 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group.	Water	67-70	insulin	Homo sapiens	0-7
23596182-10	2013	Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P &lt; 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group.	Water	111-114	insulin	Homo sapiens	0-7
23596182-10	2013	Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P &lt; 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group.	Water	111-114	insulin	Homo sapiens	0-7
23596182-10	2013	Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P &lt; 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group.	Water	111-114	insulin	Homo sapiens	0-7
23596182-10	2013	Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P &lt; 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group.	Water	111-114	insulin	Homo sapiens	0-7
23596182-11	2013	Insulin sensitivity correlated positively with frontal NAA/Cr and NAA/H2O and temporal Glx/H2O and negatively with temporal myo-inositol/Cr and myo-inositol/H2O assessed during the second (1)H-MRS (all P &lt; 0.05).	Water	70-73	insulin	Homo sapiens	0-7
23596182-11	2013	Insulin sensitivity correlated positively with frontal NAA/Cr and NAA/H2O and temporal Glx/H2O and negatively with temporal myo-inositol/Cr and myo-inositol/H2O assessed during the second (1)H-MRS (all P &lt; 0.05).	Water	91-94	insulin	Homo sapiens	0-7
23596182-11	2013	Insulin sensitivity correlated positively with frontal NAA/Cr and NAA/H2O and temporal Glx/H2O and negatively with temporal myo-inositol/Cr and myo-inositol/H2O assessed during the second (1)H-MRS (all P &lt; 0.05).	Water	91-94	insulin	Homo sapiens	0-7
23686005-4	2013	In this study, we investigated whether water extract of S. chinensis fruit (WESC) has the ability to attenuate the expression of pro-inflammatory mediators such as nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor-alpha (TNF-alpha) in LPS-stimulated RAW 264.7 macrophage cells.	Water	39-44	tumor necrosis factor	Mus musculus	241-250
23608990-1	2013	The aim of this study is to investigate the use of keratin colloidal solution, which was obtained from wool, for the removal of Pb(II) from water.	Water	140-145	submaxillary gland androgen regulated protein 3B	Homo sapiens	128-134
23608990-8	2013	From these results, we conclude that keratin colloidal solution is useful for the treatment of water polluted with Pb(II).	Water	95-100	submaxillary gland androgen regulated protein 3B	Homo sapiens	115-121
23764826-7	2013	The analysis of existing crystallographic data for the reactivation conformation of MetH enzyme (1K7Y (@3.0 A); 1K98 (@3.8 A) and 3IVA (@2.7 A)) indicates that the Y1139 residue and the beta-axial H2O ligand in the MetH-bound Co(II)Cbx complex are equidistant from the Co(II) ion (Y1139Co(II)=3.97 A; H2OCo(II)=3.96 A).	Water	197-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	269-275
23856493-3	2013	Intracerebroventricular infusion of Ang II at 1.0, 2.5, and 12.5 ng/min for 2 weeks caused dose-related increases in water intake, Ang II concentration in the cerebrospinal fluid, and blood pressure.	Water	117-122	angiotensinogen	Homo sapiens	36-42
23413086-5	2013	As the FNG concentration increased, network formation increased, but porosity and water-uptake ability were slightly reduced at high FNG concentrations.	Water	82-87	fibrinogen beta chain	Homo sapiens	7-10
23413086-5	2013	As the FNG concentration increased, network formation increased, but porosity and water-uptake ability were slightly reduced at high FNG concentrations.	Water	82-87	fibrinogen beta chain	Homo sapiens	133-136
22949376-1	2013	Water-soluble graphene oxide (GO) with a two-dimensional layered nanostructure was synthesized and used as a quencher to construct a highly sensitive and selective fluorescence resonance energy transfer (FRET) aptasensor for sensing Immunoglobulin E (IgE).	Water	0-5	immunoglobulin heavy constant epsilon	Homo sapiens	233-249
22936038-5	2013	The current data show the influence of central AngII administration on water consumption in a concentration-dependent fashion, but also demonstrate that the water intake response to AngII was strikingly attenuated in 16-week-old LP.	Water	157-162	angiotensinogen	Rattus norvegicus	182-187
22949376-1	2013	Water-soluble graphene oxide (GO) with a two-dimensional layered nanostructure was synthesized and used as a quencher to construct a highly sensitive and selective fluorescence resonance energy transfer (FRET) aptasensor for sensing Immunoglobulin E (IgE).	Water	0-5	immunoglobulin heavy constant epsilon	Homo sapiens	251-254
23549977-3	2013	Water channel proteins known as aquaporins (AQP)s, notably AQP-1, appear to be involved in the arterial capillary proliferation in the cirrhotic liver.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	59-64
23893133-4	2013	In this study, we determined the pseudoatomic structure of full-length mammalian aquaporin-0 (AQP0, Bos taurus) in complex with CaM, using EM to elucidate how this signaling protein modulates water-channel function.	Water	192-197	major intrinsic protein of lens fiber	Homo sapiens	81-92
23851226-8	2013	Alterations in MLC1 trafficking and distribution were observed in macrophages from MLC1-mutated patients, which also showed changes in the expression and localization of several proteins involved in plasma membrane permeability, ion and water homeostasis and ion-regulated exocytosis.	Water	237-242	modulator of VRAC current 1	Homo sapiens	15-19
23851226-8	2013	Alterations in MLC1 trafficking and distribution were observed in macrophages from MLC1-mutated patients, which also showed changes in the expression and localization of several proteins involved in plasma membrane permeability, ion and water homeostasis and ion-regulated exocytosis.	Water	237-242	modulator of VRAC current 1	Homo sapiens	83-87
23893133-4	2013	In this study, we determined the pseudoatomic structure of full-length mammalian aquaporin-0 (AQP0, Bos taurus) in complex with CaM, using EM to elucidate how this signaling protein modulates water-channel function.	Water	192-197	major intrinsic protein of lens fiber	Homo sapiens	94-98
23893133-5	2013	Molecular dynamics and functional mutation studies reveal how CaM binding inhibits AQP0 water permeability by allosterically closing the cytoplasmic gate of AQP0.	Water	88-93	major intrinsic protein of lens fiber	Homo sapiens	83-87
23893133-5	2013	Molecular dynamics and functional mutation studies reveal how CaM binding inhibits AQP0 water permeability by allosterically closing the cytoplasmic gate of AQP0.	Water	88-93	major intrinsic protein of lens fiber	Homo sapiens	157-161
23534338-1	2013	We report on the reaction dynamics of the monosolvated SN2 reaction of cold OH(-)(H2O) with CH3I that have been studied using crossed beam ion imaging.	Water	82-85	solute carrier family 38 member 5	Homo sapiens	55-58
23738737-8	2013	When the rate of sucrose production exceeds the rate at which sucrose is loaded into the phloem, the surplus sucrose is carried toward the stomata by the transpiration stream and stimulates stomatal closure via HXK, thereby preventing the loss of precious water.	Water	256-261	hexokinase 1	Homo sapiens	211-214
23468227-0	2013	Contributions of water transfer energy to protein-ligand association and dissociation barriers: Watermap analysis of a series of p38alpha MAP kinase inhibitors.	Water	17-22	mitogen-activated protein kinase 14	Homo sapiens	129-137
23477501-0	2013	Safety and toxicological evaluation of a novel, water-soluble undenatured type II collagen.	Water	48-53	collagen type II alpha 1 chain	Gallus gallus	74-90
23477501-1	2013	This study was conducted to determine the broad-spectrum safety of a novel, water-soluble undenatured type II collagen (NEXT-II) derived from chicken sternum cartilage.	Water	76-81	collagen type II alpha 1 chain	Gallus gallus	102-118
24039402-2	2013	CF is caused by loss or dysfunction of the CF transmembrane conductance regulator (CFTR) protein which is responsible for transepithelial chloride and water transport.	Water	151-156	CF transmembrane conductance regulator	Homo sapiens	43-81
24039402-2	2013	CF is caused by loss or dysfunction of the CF transmembrane conductance regulator (CFTR) protein which is responsible for transepithelial chloride and water transport.	Water	151-156	CF transmembrane conductance regulator	Homo sapiens	83-87
23534338-2	2013	Two SN2 reaction channels are possible for this reaction: Formation of unsolvated I(-) and of solvated I(-)(H2O) products.	Water	108-111	solute carrier family 38 member 5	Homo sapiens	4-7
23530568-6	2013	We report a staged study to address the effects of various aspects of protein flexibility and inclusion of active site water molecules on docking effectiveness to retrieve (and to be able to predict) correct ligand poses and to rank docked ligands in relation to their biological activity for CHK1, ERK2, LpxC, and UPA.	Water	119-124	checkpoint kinase 1	Homo sapiens	293-297
24015248-5	2013	We evaluated the antiestrogenic and antiandrogenic activity of 18 bottled water products in reporter gene assays for human estrogen receptor alpha and androgen receptor.	Water	74-79	estrogen receptor 1	Homo sapiens	123-168
23906334-2	2013	In this study, 19F NMR and near-UV circular dichroism (CD) are used to characterize a transition to a thermal folding intermediate of calmodulin, a water-soluble protein, which is biosynthetically enriched with 3-fluorophenylalanine (3F-Phe).	Water	148-153	calmodulin 1	Homo sapiens	134-144
23530568-6	2013	We report a staged study to address the effects of various aspects of protein flexibility and inclusion of active site water molecules on docking effectiveness to retrieve (and to be able to predict) correct ligand poses and to rank docked ligands in relation to their biological activity for CHK1, ERK2, LpxC, and UPA.	Water	119-124	mitogen-activated protein kinase 1	Homo sapiens	299-303
23530568-6	2013	We report a staged study to address the effects of various aspects of protein flexibility and inclusion of active site water molecules on docking effectiveness to retrieve (and to be able to predict) correct ligand poses and to rank docked ligands in relation to their biological activity for CHK1, ERK2, LpxC, and UPA.	Water	119-124	proline rich acidic protein 1	Homo sapiens	315-318
23968114-1	2013	The aim of this study is to simultaneously monitor the excess partial Gibbs energies, enthalpies, and entropies of water and white egg lysozyme and demonstrate how these quantities correlate with the coverage of the protein macromolecules by water molecules.	Water	242-247	lysozyme	Homo sapiens	135-143
23972849-4	2013	A series of topologically equivalent water-mediated beta-strand bridging interactions within the pseudosymmetric beta-trefoil fold of IL-1beta highlight the backbone water interactions that stabilize the secondary and tertiary structure of the protein.	Water	37-42	interleukin 1 beta	Homo sapiens	134-142
23972849-4	2013	A series of topologically equivalent water-mediated beta-strand bridging interactions within the pseudosymmetric beta-trefoil fold of IL-1beta highlight the backbone water interactions that stabilize the secondary and tertiary structure of the protein.	Water	166-171	interleukin 1 beta	Homo sapiens	134-142
28811453-1	2013	Lysozyme (LSZ)-loaded poly-L-lactide (PLLA) porous microparticles (PMs) were successfully prepared by a compressed CO2 antisolvent process in combination with a water-in-oil emulsion process using LSZ as a drug model and ammonium bicarbonate as a porogen.	Water	161-166	lysozyme	Homo sapiens	0-8
28811453-1	2013	Lysozyme (LSZ)-loaded poly-L-lactide (PLLA) porous microparticles (PMs) were successfully prepared by a compressed CO2 antisolvent process in combination with a water-in-oil emulsion process using LSZ as a drug model and ammonium bicarbonate as a porogen.	Water	161-166	lysozyme	Homo sapiens	10-13
23764894-7	2013	NHE3 knockout mice (NHE3-/-) display impaired intestinal Na+, water, and Ca2+ absorption.	Water	62-67	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	0-4
23764894-7	2013	NHE3 knockout mice (NHE3-/-) display impaired intestinal Na+, water, and Ca2+ absorption.	Water	62-67	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	20-24
23806103-11	2013	Films containing Co(II) reached current densities of 6.0 mA/cm(2) at +1.8 V vs NHE in H2O.	Water	86-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
23817308-1	2013	The new compound MnF(2-x)(OH)x (x ~ 0.8) was synthesized by a hydrothermal route from a 1 : 1 molar ratio of lithium fluoride and manganese acetate in an excess of water.	Water	164-169	forkhead box K1	Homo sapiens	17-20
23542084-7	2013	The detection limits were 52.56 +- 0.125 pg/mL for tap water and 51.42 +- 0.453 pg/mL for wastewater.	Water	55-60	SEC14 like lipid binding 2	Homo sapiens	51-54
23764894-17	2013	Together these results implicate NHE3 in intestinal Ca(2+) absorption and support the theory that this is, at least partially, due to the role of NHE3 in Na+ and water absorption.	Water	162-167	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	146-150
23783808-0	2013	The water-soluble inclusion complex of ilexgenin A with beta-cyclodextrin polymer--a novel lipid-lowering drug candidate.	Water	4-9	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	39-50
23783808-1	2013	A new water-soluble inclusion complex of ilexgenin A (IGA) with beta-cyclodextrin polymer (CDP) was prepared by a facile strategy and characterized by (1)H NMR , FT-IR, and UV-vis spectroscopy.	Water	6-11	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	41-52
23783808-1	2013	A new water-soluble inclusion complex of ilexgenin A (IGA) with beta-cyclodextrin polymer (CDP) was prepared by a facile strategy and characterized by (1)H NMR , FT-IR, and UV-vis spectroscopy.	Water	6-11	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	54-57
23783808-2	2013	Compared with IGA and the inclusion complex of IGA with beta-cyclodextrin (IGA-CD), the solubility of IGA-beta-cyclodextrin polymer (IGA-CDP) was greatly enhanced due to the water-soluble CDP host.	Water	174-179	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	47-50
23783808-2	2013	Compared with IGA and the inclusion complex of IGA with beta-cyclodextrin (IGA-CD), the solubility of IGA-beta-cyclodextrin polymer (IGA-CDP) was greatly enhanced due to the water-soluble CDP host.	Water	174-179	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	47-50
23783808-2	2013	Compared with IGA and the inclusion complex of IGA with beta-cyclodextrin (IGA-CD), the solubility of IGA-beta-cyclodextrin polymer (IGA-CDP) was greatly enhanced due to the water-soluble CDP host.	Water	174-179	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	47-50
23783808-2	2013	Compared with IGA and the inclusion complex of IGA with beta-cyclodextrin (IGA-CD), the solubility of IGA-beta-cyclodextrin polymer (IGA-CDP) was greatly enhanced due to the water-soluble CDP host.	Water	174-179	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	47-50
23967108-0	2013	Genetic susceptible locus in NOTCH2 interacts with arsenic in drinking water on risk of type 2 diabetes.	Water	71-76	notch receptor 2	Homo sapiens	29-35
23783808-9	2013	Furthermore, the efficacy and potency of water-soluble inclusion complex of IGA-CDP was 2-3 times higher than that of IGA.	Water	41-46	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	76-79
23783808-9	2013	Furthermore, the efficacy and potency of water-soluble inclusion complex of IGA-CDP was 2-3 times higher than that of IGA.	Water	41-46	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	118-121
23947873-4	2013	Here we report a computational procedure for accurate evaluation of the site-site DCFs of liquid water based on three popular molecular models (viz., SPC, SPC/E, and TIP3P).	Water	97-102	proline rich protein gene cluster	Homo sapiens	150-153
23947873-4	2013	Here we report a computational procedure for accurate evaluation of the site-site DCFs of liquid water based on three popular molecular models (viz., SPC, SPC/E, and TIP3P).	Water	97-102	proline rich protein gene cluster	Homo sapiens	155-158
23915297-5	2013	fAbeta, but not oAbeta, enhanced the IFN-gamma-stimulated nitric oxide production and iNOS expression.The ethanol/water extracts of Cudrania cochinchinensis (CC-EW) and the purified isolated components (i.e. CCA to CCF) effectively reduced the nitric oxide production and iNOS expression stimulated by IFN-gamma combined with fAbeta.	Water	114-119	interferon gamma	Mus musculus	37-46
23927290-8	2013	The method is validated by predicting the number and location of water molecules in 5 pockets in the protein Interleukin-1beta for which experimental water occupancy data are available.	Water	65-70	interleukin 1 beta	Homo sapiens	109-126
23927290-8	2013	The method is validated by predicting the number and location of water molecules in 5 pockets in the protein Interleukin-1beta for which experimental water occupancy data are available.	Water	150-155	interleukin 1 beta	Homo sapiens	109-126
23940507-4	2013	This study was undertaken to determine whether oral treatment with a water-soluble N-hydroxy-2,2,6,6-tetramethylpiperidine derivative (OT-440) protects against loss of Thy-1 promoter activation following optic nerve crush and whether this effect targets the earlier quick phase or the later slow phase.	Water	69-74	thymus cell antigen 1, theta	Mus musculus	168-173
23466333-3	2013	These reactions occur in proteins such as cytochrome c, a heme-containing water-soluble protein, the bacteriochlorophyll-containing reaction center, and photosystem II where water is oxidized at the manganese cluster.	Water	74-79	cytochrome c, somatic	Homo sapiens	42-54
23907880-2	2013	Ag1 is five-coordinated by three O atoms from one L1 anion, one L2 anion and one water molecule, one N atom from one L2 anion and one AgI cation in a distorted trigonal-bipyramidal coordination geometry.	Water	81-86	NBPF member 10	Homo sapiens	0-3
23466333-3	2013	These reactions occur in proteins such as cytochrome c, a heme-containing water-soluble protein, the bacteriochlorophyll-containing reaction center, and photosystem II where water is oxidized at the manganese cluster.	Water	174-179	cytochrome c, somatic	Homo sapiens	42-54
22934736-6	2013	Tablets containing ethylcellulose 10 or 45 (EC10, EC45) from a water-insoluble polymer increased the adhesive force and tensile strength.	Water	63-68	ribosomal protein L15	Homo sapiens	50-54
23374161-6	2013	In gastropods that copulate, trail-following is an important component in mate-searching, either as an alternative, or in addition to the release of water- or air-borne pheromones.	Water	149-154	TNF superfamily member 10	Homo sapiens	29-34
23807682-2	2013	Median drug concentrations were quite similar in the majority of samples, cerca 1 mug L-1 ranging from 0.06 to 2.67 mug L-1 in both water.	Water	132-137	immunoglobulin kappa variable 1-16	Homo sapiens	120-123
23672418-1	2013	Aquaporin (AQP) 1 and AQP 4 are members of the aquaporin water channel family that play an important role in reabsorption of water from the renal tubular fluid to concentrate urine.	Water	57-62	aquaporin 1	Bos taurus	0-17
23672418-1	2013	Aquaporin (AQP) 1 and AQP 4 are members of the aquaporin water channel family that play an important role in reabsorption of water from the renal tubular fluid to concentrate urine.	Water	125-130	aquaporin 1	Bos taurus	0-17
23672418-6	2013	We concluded that AQP 1 and AQP 4 in the bovine kidney showed some differences from other species in renal trans-epithelial water transport.	Water	124-129	aquaporin 1	Bos taurus	18-23
23582042-7	2013	Inactivation of AtKPNB1 increased stomatal closure in response to ABA, reduced the rate of water loss, and substantially enhanced drought tolerance.	Water	91-96	ARM repeat superfamily protein	Arabidopsis thaliana	16-23
23680159-0	2013	The water permeability of lens aquaporin-0 depends on its lipid bilayer environment.	Water	4-9	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	31-42
23680159-1	2013	Aquaporin-0 (AQP0), the primary water channel in lens fiber cells, is critical to lens development, organization, and function.	Water	32-37	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	0-11
23680159-1	2013	Aquaporin-0 (AQP0), the primary water channel in lens fiber cells, is critical to lens development, organization, and function.	Water	32-37	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	13-17
23680159-4	2013	Here we measure the unit water permeability of AQP0 in different proteoliposomes with cholesterol/phospholipid ratios and external pHs similar to those found in the cortex and nucleus of the lens.	Water	25-30	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	47-51
23680159-9	2013	These data imply that AQP0 water permeability is regulated by bilayer lipid composition, so that AQP0 permeability would be significantly less in the lens nucleus than in the lens cortex.	Water	27-32	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	22-26
23680159-9	2013	These data imply that AQP0 water permeability is regulated by bilayer lipid composition, so that AQP0 permeability would be significantly less in the lens nucleus than in the lens cortex.	Water	27-32	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	97-101
23230082-6	2013	Such particles contain a segment of phospholipid bilayer and are stabilized by two apoA-I molecules that are arranged in an anti-parallel, double-belt conformation around the edge of the disc, shielding the hydrophobic phospholipid acyl chains from exposure to water.	Water	261-266	apolipoprotein A1	Homo sapiens	83-89
23508938-5	2013	The NHE3-PT KO mice tolerated NH4Cl acid load well (added to the drinking water) and showed NH4 excretion rates comparable to WT mice at 2 and 5 days after NH4Cl loading without disproportionate metabolic acidosis after 5 days of acid load.	Water	74-79	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	4-8
23701531-3	2013	Vasopressin primarily promotes water reabsorption in the kidney to maintain body fluid balance, but also increases vasoconstriction.	Water	31-36	arginine vasopressin	Homo sapiens	0-11
23911977-3	2013	Our model system consists of ubiquitin, a protein whose dynamic features are closely related to its ability to bind to multiple partners, in a 325 g L-1 solution of glucose in water, a condition widely employed in in vitro studies of crowding effects.	Water	176-181	immunoglobulin kappa variable 1-16	Homo sapiens	149-152
23684380-2	2013	We have previously reported that AQP9 is highly expressed in syncytiotrophoblast from normal placentas and shows an overexpression in preeclamptic placentas, with a lack of functionality for water transport.	Water	191-196	aquaporin 9	Homo sapiens	33-37
23684380-11	2013	Accordingly with the decrease in AQP9 expression, water uptake decreased in explants exposed to hypoxia or treated with CoCl2.	Water	50-55	aquaporin 9	Homo sapiens	33-37
24224084-11	2013	In rats administered AngII and propranolol, reductions in food and water intake and body weight were eliminated.	Water	67-72	angiotensinogen	Rattus norvegicus	21-26
23571113-5	2013	The results indicated that the Fe-Cu binary oxide with a Cu: Fe molar ratio of 1:2 had excellent performance in removing both As(V) and As(III) from water, and the maximal adsorption capacities for As(V) and As(III) were 82.7 and 122.3 mg/g at pH 7.0, respectively.	Water	149-154	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	126-131
23873551-12	2013	Our findings hinted that HIF-1alpha might be associated with the development of AS induced by excess salt in drinking water in broiler chickens.	Water	118-123	hypoxia inducible factor 1 alpha subunit	Gallus gallus	25-35
23770575-1	2013	The radical homopolymerisation of 2-trifluoromethacrylic acid (MAF) initiated by Na2S2O8 in water, under the influence of pH, led to original water soluble surfactants, the decomposition of which was investigated.	Water	92-97	MAF bZIP transcription factor	Homo sapiens	63-66
24558828-1	2013	OBJECTIVE: To investigate the effects of Drynariae Rhizoma water-extraction on the ability of osteogenic differentiation and the expression of TGF-beta1 and BMP-2 in inducing mesenchymal stem cells (MSCs) differentiation into osteoblast and its mechanism.	Water	59-64	transforming growth factor beta 1	Homo sapiens	143-152
24558828-6	2013	The classic group, Drynariae Rhizoma water-extraction group and Drynariae Rhizoma water-extraction + classic group could promote the osteogenic differentiation of MSCs and increase the expression of TGF-beta1 and BMP-2.	Water	37-42	transforming growth factor beta 1	Homo sapiens	199-208
24558828-6	2013	The classic group, Drynariae Rhizoma water-extraction group and Drynariae Rhizoma water-extraction + classic group could promote the osteogenic differentiation of MSCs and increase the expression of TGF-beta1 and BMP-2.	Water	82-87	transforming growth factor beta 1	Homo sapiens	199-208
24558828-8	2013	Epimedium water-extraction can improve the differentiation of MSC into osteoblast and its mechanism may be related to increasing the expression of TGF-beta1 and BMP-2.	Water	10-15	transforming growth factor beta 1	Homo sapiens	147-156
23770575-1	2013	The radical homopolymerisation of 2-trifluoromethacrylic acid (MAF) initiated by Na2S2O8 in water, under the influence of pH, led to original water soluble surfactants, the decomposition of which was investigated.	Water	142-147	MAF bZIP transcription factor	Homo sapiens	63-66
23845496-5	2013	Probe TSP1 was used to detect sulfite in three realistic samples (mineral water, sugar and white wine) with good recovery.	Water	74-79	thrombospondin 1	Homo sapiens	6-10
23657858-8	2013	Consistent with a primary effect on water transport, IL-1beta infusion markedly reduced inner medullary aquaporin-2 expression (P &lt; 0.05) and did not alter urinary Na+ or K+ excretion.	Water	36-41	interleukin 1 beta	Mus musculus	53-61
23875003-4	2013	3xTg-AD mice fed 0.23% w/v lipoic acid in drinking water for 4 weeks showed an insulin mimetic effect that consisted of increased brain glucose uptake, activation of the insulin receptor substrate and of the PI3K/Akt signaling pathway.	Water	51-56	insulin	Homo sapiens	79-86
23875003-4	2013	3xTg-AD mice fed 0.23% w/v lipoic acid in drinking water for 4 weeks showed an insulin mimetic effect that consisted of increased brain glucose uptake, activation of the insulin receptor substrate and of the PI3K/Akt signaling pathway.	Water	51-56	AKT serine/threonine kinase 1	Homo sapiens	213-216
23795818-0	2013	Design and development of stable, water-soluble, human Toll-like receptor 2 specific monoacyl lipopeptides as candidate vaccine adjuvants.	Water	34-39	toll like receptor 2	Homo sapiens	55-75
23795818-6	2013	These studies have led to a fully optimized, chemically stable, and highly water-soluble human TLR2-specific agonist, which was found to have an excellent safety profile and displayed prominent adjuvantic activities in rabbit models.	Water	75-80	toll like receptor 2	Homo sapiens	95-99
23883043-2	2013	This work provides an accurate yet efficient calculation procedure for evaluating the angular-dependent DCF of bulk SPC/E water.	Water	122-127	proline rich protein gene cluster	Homo sapiens	116-119
23531819-1	2013	Water transport across the plasma membrane depends on the presence of the water channel aquaporin (AQP), which mediates the bulk movement of water through osmotic and pressure gradients.	Water	0-5	aquaporin	Drosophila melanogaster	99-102
23862950-3	2013	In this paper, we show calculations of the frequency spectrum for light and heavy water at room temperature using two flexible point charge potentials: SPC-MPG and TIP4P/2005f.	Water	82-87	proline rich protein gene cluster	Homo sapiens	152-155
23822311-0	2013	Water polarization induced by thermal gradients: the extended simple point charge model (SPC/E).	Water	0-5	proline rich protein gene cluster	Homo sapiens	89-92
23822311-1	2013	We investigate the non-equilibrium response of extended simple point charge (SPC/E) water to thermal gradients.	Water	84-89	proline rich protein gene cluster	Homo sapiens	77-80
23822311-2	2013	Using non-equilibrium molecular dynamics simulations, we show that SPC/E water features the thermo-polarization orientation effect, namely, water becomes polarized as a response to a thermal gradient.	Water	73-78	proline rich protein gene cluster	Homo sapiens	67-70
23822311-2	2013	Using non-equilibrium molecular dynamics simulations, we show that SPC/E water features the thermo-polarization orientation effect, namely, water becomes polarized as a response to a thermal gradient.	Water	140-145	proline rich protein gene cluster	Homo sapiens	67-70
23688073-4	2013	Multiple computational trials were executed to analyze the probability of occurrence of Abeta binding by using calculation models containing a mixed lipid membrane, water layer, and one, two, or three Abetas.	Water	165-170	amyloid beta precursor protein	Homo sapiens	88-93
23688073-5	2013	The simulations demonstrated that Abeta peptides approached the membrane after fluctuation in the water layer and occasionally made steady contact with the membrane.	Water	98-103	amyloid beta precursor protein	Homo sapiens	34-39
24109269-1	2013	In the title salt, [Co(C7H9NO)2(H2O)2]Cl2, the Co(II) cation, located on an inversion center, is N,O-chelated by two hy-droxy-ethyl-pyridine ligands and coordinated by two water mol-ecules in a distorted O4N2 octa-hedral geometry.	Water	172-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
23531819-1	2013	Water transport across the plasma membrane depends on the presence of the water channel aquaporin (AQP), which mediates the bulk movement of water through osmotic and pressure gradients.	Water	74-79	aquaporin	Drosophila melanogaster	99-102
23531819-1	2013	Water transport across the plasma membrane depends on the presence of the water channel aquaporin (AQP), which mediates the bulk movement of water through osmotic and pressure gradients.	Water	141-146	aquaporin	Drosophila melanogaster	99-102
23531819-3	2013	A cDNA encoding the homologue of the water-specific Drosophila AQP [Drosophila integral protein (DRIP)] was identified through the RT-PCR of RNA isolated from the rectum of the cupreous chafer larvae, Anomala cuprea, a humus and plant root feeder.	Water	37-42	aquaporin	Drosophila melanogaster	63-66
23531819-6	2013	This is the first experimental demonstration of the presence of a water-specific AQP, namely DRIP, in the Coleoptera.	Water	66-71	aquaporin	Drosophila melanogaster	81-84
32481827-2	2013	In this paper, water-soluble MNPs have been synthesized and functionalized with an scFv antibody variant specific toward the HER2 receptor overexpressed in several breast cancer cell lines.	Water	15-20	immunglobulin heavy chain variable region	Homo sapiens	83-87
32481827-2	2013	In this paper, water-soluble MNPs have been synthesized and functionalized with an scFv antibody variant specific toward the HER2 receptor overexpressed in several breast cancer cell lines.	Water	15-20	erb-b2 receptor tyrosine kinase 2	Homo sapiens	125-129
22982061-5	2013	Cell swelling was caused by a substantial influx of extracellular Na(+) via TRPV1 channels, causing concomitant transport of water.	Water	125-130	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	76-81
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Water	127-132	cystathionine beta-synthase	Homo sapiens	0-27
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Water	127-132	cystathionine beta-synthase	Homo sapiens	29-32
23817822-4	2013	Vasopressin in turn acts on the kidneys to promote the reabsorption of water to correct the increased osmolality.	Water	71-76	arginine vasopressin	Homo sapiens	0-11
29470732-4	2013	We conducted this study to investigate the various bioplastic properties of the albumin with the use of three plasticizers - water, glycerol, and natural rubber latex.	Water	125-130	albumin	Homo sapiens	80-87
23660505-0	2013	The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption.	Water	100-105	solute carrier family 15 member 1	Homo sapiens	24-29
23903893-6	2013	Results demonstrating that infliximab, an approved inhibitor of tumor necrosis factor-alpha, can be incorporated into the conjugates using a broad range of water-soluble polymers are also presented, along with a prospectus for clinical translation.	Water	156-161	tumor necrosis factor	Homo sapiens	64-91
24137604-1	2013	Experimental gestosis, modeled by replacement of drinking water with 1.8% NaCl solution, induced oxidative stress, which was seen from accumulation of MDA (secondary LPO product) and inhibition of SOD and glutathione peroxidase in the brain, liver, and uterus of animals with gestosis.	Water	58-63	lactoperoxidase	Homo sapiens	166-169
23832989-2	2013	In the presence of catalase and/or peroxidases, hydrogen peroxide is converted to water and hypochlorite (when metabolized by myeloperoxidase).	Water	82-87	catalase	Homo sapiens	19-27
23832989-2	2013	In the presence of catalase and/or peroxidases, hydrogen peroxide is converted to water and hypochlorite (when metabolized by myeloperoxidase).	Water	82-87	myeloperoxidase	Homo sapiens	126-141
24137604-1	2013	Experimental gestosis, modeled by replacement of drinking water with 1.8% NaCl solution, induced oxidative stress, which was seen from accumulation of MDA (secondary LPO product) and inhibition of SOD and glutathione peroxidase in the brain, liver, and uterus of animals with gestosis.	Water	58-63	superoxide dismutase 1	Homo sapiens	197-200
23351063-8	2013	A catalytic water, bound between the OE1-atoms of the two catalytic glutamates, Glu103 and Glu123, plays an important role in the enoyl-CoA isomerase and the enoyl-CoA hydratase reaction mechanism of MFE1.	Water	12-17	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Rattus norvegicus	200-204
23700289-2	2013	Arterial underfilling with consequent neurohormonal activation, systemic and intrarenal vasoconstriction, and salt and water retention cause the main clinical features of CRS which include a progressive decline in renal function, worsening renal function during treatment of heart failure (HF) decompensation and resistance to loop diuretics.	Water	119-124	twist family bHLH transcription factor 1	Homo sapiens	171-174
23670301-12	2013	Thus, MAO-A and MAO-B are both expressed in the mouse aorta, induced by in vivo lipopolysaccharide and angiotensin II treatment and contribute via the generation of H(2)O(2) to endothelial dysfunction in vascular disease models.	Water	165-170	monoamine oxidase B	Mus musculus	16-21
23690341-9	2013	Functional expression of aquaporin-1 tyrosine phosphorylation on red blood cell membranes increased significantly at 25 and 50 minutes after subjects ingested 500 mL of water compared with that before water ingestion.	Water	169-174	aquaporin 1 (Colton blood group)	Homo sapiens	25-36
23690341-9	2013	Functional expression of aquaporin-1 tyrosine phosphorylation on red blood cell membranes increased significantly at 25 and 50 minutes after subjects ingested 500 mL of water compared with that before water ingestion.	Water	201-206	aquaporin 1 (Colton blood group)	Homo sapiens	25-36
23690341-10	2013	This study concludes that water ingestion produces upregulation of aquaporin-1 tyrosine phosphorylation on red blood cell, which presents as a novel biological marker that occurs simultaneously with the osmopressor response.	Water	26-31	aquaporin 1 (Colton blood group)	Homo sapiens	67-78
23562552-6	2013	In the presence of a phospholipid monolayer, the surface activities of two alpha-Syn forms are much greater than observed at the air/water interface.	Water	133-138	synuclein alpha	Bos taurus	75-84
23610159-0	2013	Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome.	Water	14-19	component of oligomeric golgi complex 2	Homo sapiens	36-51
23562552-3	2013	We have determined the equilibrium surface pressure of the two forms of alpha-Syn (monomeric and fibrillar form) at the air/water interface.	Water	124-129	synuclein alpha	Bos taurus	72-81
23562552-5	2013	The monomeric alpha-Syn adsorbed more rapidly at the air/water interface with a maximal adsorption rate at least 60-times higher than the fibrillar form.	Water	57-62	synuclein alpha	Bos taurus	14-23
23931090-6	2013	GCL/GCP, in either water or 10% ethanol vehicles, increased the skin penetration and skin deposition of MAP in comparison with GC, hydroxypropylmethylcellulose, and carbopol, while sustaining its release from the polymer gels.	Water	19-24	golgin B1	Homo sapiens	4-7
23609837-9	2013	A water-deprivation test and vasopressin administration indicated NDI.	Water	2-7	arginine vasopressin receptor 2	Homo sapiens	66-69
23610159-3	2013	Serum analysis showed that consumption of H2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels.	Water	50-55	component of oligomeric golgi complex 2	Homo sapiens	124-139
23610159-3	2013	Serum analysis showed that consumption of H2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels.	Water	50-55	component of oligomeric golgi complex 2	Homo sapiens	141-146
23610159-7	2013	In conclusion, supplementation with H2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome.	Water	44-49	component of oligomeric golgi complex 2	Homo sapiens	74-79
23610159-7	2013	In conclusion, supplementation with H2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome.	Water	44-49	apolipoprotein B	Homo sapiens	84-88
23524259-5	2013	Downregulation of Period 2 and 3 mRNA expression levels and a subsequent decrease in food and water intake were observed.	Water	94-99	period circadian clock 2	Mus musculus	18-32
23471623-0	2013	A novel homogeneous time-resolved fluoroimmunoassay for carcinoembryonic antigen based on water-soluble quantum dots.	Water	90-95	CEA cell adhesion molecule 3	Homo sapiens	56-80
23479206-2	2013	Sensors 1 and 2 were selective for Hg(2+) ion among a series of metal ions in H2O-DMSO with association constants of 4.60x10(4) and 5.90x10(4) M(-1) and detection limits of 140 and 101.6 muM, respectively.	Water	78-81	latexin	Homo sapiens	187-190
23423255-6	2013	In PKD, increased water intake slows renal cyst growth in animals via direct vasopressin suppression, and pharmacologic blockade of renal vasopressin-V2 receptors has recently been shown to be efficacious in retarding cyst growth in PKD patients.	Water	18-23	arginine vasopressin	Homo sapiens	77-88
23913386-1	2013	The renin-angiotensin-aldosterone system plays a key role in regulating blood pressure by maintaining vascular tone and the water/sodium balance.	Water	124-129	renin	Homo sapiens	4-9
23649707-2	2013	[Co(bik)3][{W(CN)8}3{Co(bik)2}3] 2 H2O 13 CH3CN (see figure) exhibits a thermally-induced electron-transfer-coupled spin transition between the two states: Co(HS)(II)-W(V) Co(LS)(III)-W(IV).	Water	35-38	BCL2 interacting killer	Homo sapiens	4-7
23852264-1	2013	Arginine-vasopressin (AVP) facilitates water reabsorption by renal collecting duct principal cells and thereby fine-tunes body water homeostasis.	Water	39-44	arginine vasopressin	Rattus norvegicus	0-20
23852264-1	2013	Arginine-vasopressin (AVP) facilitates water reabsorption by renal collecting duct principal cells and thereby fine-tunes body water homeostasis.	Water	39-44	arginine vasopressin	Rattus norvegicus	22-25
23852264-1	2013	Arginine-vasopressin (AVP) facilitates water reabsorption by renal collecting duct principal cells and thereby fine-tunes body water homeostasis.	Water	127-132	arginine vasopressin	Rattus norvegicus	0-20
23852264-1	2013	Arginine-vasopressin (AVP) facilitates water reabsorption by renal collecting duct principal cells and thereby fine-tunes body water homeostasis.	Water	127-132	arginine vasopressin	Rattus norvegicus	22-25
23852264-7	2013	The cells are suitable for elucidating molecular mechanisms underlying the control of AQP2 and thus to discover novel drug targets for the treatment of diseases associated with dysregulation of AVP-mediated water reabsorption.	Water	207-212	arginine vasopressin	Rattus norvegicus	194-197
23782508-6	2013	This updating seems to be mediated by the activation of angiotensin AT1 receptors in the dorsal hippocampus and local infusion of human angiotensin II (ANGII) was shown to mimic the water deprivation effects on memory reconsolidation.	Water	182-187	angiotensinogen	Homo sapiens	136-150
23782508-6	2013	This updating seems to be mediated by the activation of angiotensin AT1 receptors in the dorsal hippocampus and local infusion of human angiotensin II (ANGII) was shown to mimic the water deprivation effects on memory reconsolidation.	Water	182-187	angiotensinogen	Homo sapiens	152-157
23799081-6	2013	HOG1 mitogen activated protein kinase was activated in cells exposed to plasma in water and saline.	Water	82-87	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	0-4
23773777-2	2013	We tested the hypothesis that an ABCB1 ortholog serves as protection for the sensitive developmental processes in zebrafish embryos against adverse compounds dissolved in the water.	Water	175-180	ATP binding cassette subfamily B member 1	Homo sapiens	33-38
23773777-13	2013	CONCLUSIONS: We show that zebrafish Abcb4 is a cellular toxicant transporter and provides protection of embryos against toxic chemicals dissolved in the water.	Water	153-158	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Danio rerio	36-41
23675835-5	2013	(Science2010, 330, 341) to characterize water exchange from the four internal hydration sites in the protein bovine pancreatic trypsin inhibitor.	Water	40-45	trophoblast Kunitz domain protein 1	Bos taurus	127-144
23692429-1	2013	Electrocatalytic water oxidation occurs at fluoride-doped tin oxide (FTO) electrodes that have been surface-modified by addition of Co(II).	Water	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
23692429-3	2013	On the basis of cyclic voltammetry measurements, surface-bound Co(II) undergoes a pH-dependent 1e(-)/1H(+) oxidation to Co(III), which is followed by pH-dependent catalytic water oxidation.	Water	173-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
23692429-3	2013	On the basis of cyclic voltammetry measurements, surface-bound Co(II) undergoes a pH-dependent 1e(-)/1H(+) oxidation to Co(III), which is followed by pH-dependent catalytic water oxidation.	Water	173-178	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	120-127
23649707-2	2013	[Co(bik)3][{W(CN)8}3{Co(bik)2}3] 2 H2O 13 CH3CN (see figure) exhibits a thermally-induced electron-transfer-coupled spin transition between the two states: Co(HS)(II)-W(V) Co(LS)(III)-W(IV).	Water	35-38	BCL2 interacting killer	Homo sapiens	24-27
23618252-2	2013	The controllability and polymerization rate of SET-LRP can be adjusted by the water/THF ratio in the mixture solvent.	Water	78-83	LDL receptor related protein 1	Homo sapiens	51-54
23654226-5	2013	A comparison of FAAH acylation with a reference reaction in water suggests that transition-state stabilization is crucial for catalysis because the activation energy barrier falls by 6 kcal/mol in the presence of the active site.	Water	60-65	fatty acid amide hydrolase	Homo sapiens	16-20
23672666-4	2013	Similar to carboxypeptidase A and thermolysin, the promoted water mechanism is established for the catalysis of ACE.	Water	60-65	angiotensin I converting enzyme	Homo sapiens	112-115
23762448-1	2013	Arginine vasopressin (AVP) is released from the posterior pituitary and controls water homeostasis.	Water	81-86	arginine vasopressin	Homo sapiens	22-25
23762448-2	2013	AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to increased cAMP levels, trafficking of aquaporin-2 water channels, and consequent increased water permeability and antidiuresis.	Water	195-200	arginine vasopressin	Homo sapiens	0-3
23762448-2	2013	AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to increased cAMP levels, trafficking of aquaporin-2 water channels, and consequent increased water permeability and antidiuresis.	Water	236-241	arginine vasopressin	Homo sapiens	0-3
23376876-2	2013	Here, we have explored picosecond-resolved solvation dynamics of water molecules and associated polar amino acids in the hydrophobic cleft around Cys-34 position of Endogenous Serum Albumin (ESA).	Water	65-70	albumin	Homo sapiens	176-189
23607566-10	2013	Of the three aquaporin (Aqp) water channels, Aqp-9 was down-regulated, and Aqp-1 was up-regulated during hypoxia.	Water	29-34	aquaporin 9	Rattus norvegicus	45-50
23659478-3	2013	The antiproliferative activity of water-soluble compounds (1c, 1t, 3c, 4c and 9c, 9t, 10c, 11c, 11t, 12c, 12t, 13c) in the human cancer cell lines A549 (nonsmall cell lung carcinoma), CH1 (ovarian carcinoma), and SW480 (colon adenocarcinoma) has been assayed.	Water	34-39	Rho GTPase activating protein 9	Homo sapiens	86-89
23856265-0	2013	Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism.	Water	84-89	calcium sensing receptor	Homo sapiens	0-24
23856265-0	2013	Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism.	Water	84-89	calcium sensing receptor	Homo sapiens	26-30
23415491-4	2013	Freely dissolved PCB concentrations in sediment pore water in treated sites were also lower than overlying water concentrations indicating a reversal of the sediment from being a source to a sink of PCBs from the water column.	Water	53-58	pyruvate carboxylase	Homo sapiens	17-20
23735919-8	2013	In contrast to water immersion, water exchange during insertion has consistently increased ADR during withdrawal inspection.	Water	32-37	aldo-keto reductase family 1 member B	Homo sapiens	91-94
23735919-9	2013	Water exchange may be a suitable alternative platform to replace insertion by air insufflation in the evaluation of new adjunct measures of quality improvement to increase ADR.	Water	0-5	aldo-keto reductase family 1 member B	Homo sapiens	172-175
23732851-3	2013	Besides direct approaches to restoring mutant CFTR function, alternative therapeutic strategies may also be considered to correct the basic defect of impaired salt and water transport.	Water	168-173	CF transmembrane conductance regulator	Homo sapiens	46-50
23401165-6	2013	Downgradient acetate-stimulated water samples had much higher levels of arsenic (up to 8 muM), and 4 additional thioarsenic species were present under sulfate-reducing conditions.	Water	32-37	latexin	Homo sapiens	89-92
23479450-6	2013	Addition of cyt c into the water subphase induced increase of surface pressure of CX monolayers at relatively low initial pressure (15 mN/m) when monolayer was in liquid expanded state (LE).	Water	27-32	cytochrome c, somatic	Homo sapiens	12-17
23479450-7	2013	This may be due interaction of positively charged cyt c with negatively charged carboxylic groups of CX and also by its penetration into the air-water interface.	Water	145-150	cytochrome c, somatic	Homo sapiens	50-55
23411247-6	2013	Use of partially dephosphorylated beta-casein to stabilise oil-in-water emulsions resulted in larger fat globules compared to control beta-casein, but such globules were less susceptible to aggregation in the presence of 15 or 30 mM CaCl(2).	Water	66-71	casein beta	Bos taurus	34-45
23947022-7	2013	It was also found that the removal of CS2 decreased when there was water vapor in gas stream.	Water	67-72	chorionic somatomammotropin hormone 2	Homo sapiens	38-41
23858976-2	2013	The insulin-loaded PCL nanoparticles were prepared by double emulsion method (water-in-oil-in-water) using Pluronic F68 as emulsifier.	Water	78-83	insulin	Homo sapiens	4-11
23322705-8	2013	Additionally, these data implicate the water-soluble inositol polyphosphates as mediators of the Cx43-dependent amplification of the osteoblast response to FGF2, and suggest that these low molecular weight second messengers may be biologically relevant mediators of osteoblast function that are communicated by Cx43-gap junctions.	Water	39-44	fibroblast growth factor 2	Homo sapiens	156-160
23858976-2	2013	The insulin-loaded PCL nanoparticles were prepared by double emulsion method (water-in-oil-in-water) using Pluronic F68 as emulsifier.	Water	94-99	insulin	Homo sapiens	4-11
23858976-7	2013	These results suggest that insulin-loaded PCL nanoparticles prepared by water-in-oil-in-water emulsion method are biocompatible, efficient and safe insulin-delivering system with controlled insulin release, which indicates that it may be a powerful tool for insulin-dependent patients care.	Water	72-77	insulin	Homo sapiens	27-34
23858976-7	2013	These results suggest that insulin-loaded PCL nanoparticles prepared by water-in-oil-in-water emulsion method are biocompatible, efficient and safe insulin-delivering system with controlled insulin release, which indicates that it may be a powerful tool for insulin-dependent patients care.	Water	72-77	insulin	Homo sapiens	148-155
23462572-6	2013	When we administered NSC74859, a specific inhibitor of phosphorylated STAT3 (pSTAT3), the water content became normalized.	Water	90-95	signal transducer and activator of transcription 3	Mus musculus	70-75
23858976-7	2013	These results suggest that insulin-loaded PCL nanoparticles prepared by water-in-oil-in-water emulsion method are biocompatible, efficient and safe insulin-delivering system with controlled insulin release, which indicates that it may be a powerful tool for insulin-dependent patients care.	Water	72-77	insulin	Homo sapiens	148-155
23858976-7	2013	These results suggest that insulin-loaded PCL nanoparticles prepared by water-in-oil-in-water emulsion method are biocompatible, efficient and safe insulin-delivering system with controlled insulin release, which indicates that it may be a powerful tool for insulin-dependent patients care.	Water	88-93	insulin	Homo sapiens	27-34
23553750-4	2013	PEBT significantly improved Abeta-induced learning deficits on the training session in the Morris water maze.	Water	98-103	histocompatibility 2, class II antigen A, beta 1	Mus musculus	28-33
23596160-3	2013	Four groups of rats were used: 1) control (C; injected with vehicle and provided with tap water), 2) grape powder-treated (GP; injected with vehicle and provided for 3 wk with 15 g/L grape powder dissolved in tap water), 3) BSO-treated [injected with BSO (300 mg/kg body weight), i.p.	Water	213-218	nuclear RNA export factor 1	Rattus norvegicus	209-212
23612149-5	2013	Furthermore, AtPNP-A signals via the second messenger cyclic guanosine 3",5"-monophosphate and modulates ion and water transport and homeostasis.	Water	113-118	plant natriuretic peptide A	Arabidopsis thaliana	13-20
23585571-0	2013	Water-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors.	Water	0-5	Ly6/neurotoxin 1	Homo sapiens	14-19
23649652-1	2013	Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen.	Water	214-219	superoxide dismutase 2, mitochondrial	Mus musculus	0-30
23649652-1	2013	Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen.	Water	214-219	superoxide dismutase 2, mitochondrial	Mus musculus	32-37
24900720-4	2013	As expected, the uncleaved water-soluble prodrugs 7 and 8 showed no activity toward the enzymatic targets (c-Src and c-Abl) but revealed promising antiproliferative activity in myeloid cell lines, as a consequence of the in vitro hydrolysis of the selected solubilizing moiety, followed by the release of the active compounds (1 and 2).	Water	27-32	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	107-112
23704941-11	2013	Taken together, these data show that PRR present in the UB epithelia performs essential functions during UB branching morphogenesis and collecting duct development via control of Ret/Wnt11 pathway gene expression, UB cell survival, activation of Erk1/2, terminal differentiation and function of collecting duct cells needed for maintaining adequate water and acid-base homeostasis.	Water	349-354	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	37-40
23675776-5	2013	3-HOA-NO3 gelated only water and CCl4 and 3-HOA-BF4 formed only hydrogels.	Water	23-28	NBL1, DAN family BMP antagonist	Homo sapiens	6-9
23597244-1	2013	A new approach to perform single-electron transfer living radical polymerization (SET-LRP) in water is described.	Water	94-99	LDL receptor related protein 1	Homo sapiens	86-89
23590665-4	2013	STE micelles competitively adsorbed at the oil-water interface with SPI, forming a mixed SPI and STE interfacial layer, thus resulting in a decrease in particle size and evident enhancement in the physical stability of SPI-based emulsions.	Water	47-52	chromogranin A	Homo sapiens	68-71
23578300-3	2013	The homoglycopolypeptide formed multimicellar aggregates in water above a critical concentration of 0.9 muM due to phase separation.	Water	60-65	latexin	Homo sapiens	104-107
23577649-0	2013	Liquid/gas and liquid/liquid phase equilibria of the system water/bovine serum albumin.	Water	60-65	albumin	Homo sapiens	73-86
23590665-4	2013	STE micelles competitively adsorbed at the oil-water interface with SPI, forming a mixed SPI and STE interfacial layer, thus resulting in a decrease in particle size and evident enhancement in the physical stability of SPI-based emulsions.	Water	47-52	chromogranin A	Homo sapiens	89-92
23590665-4	2013	STE micelles competitively adsorbed at the oil-water interface with SPI, forming a mixed SPI and STE interfacial layer, thus resulting in a decrease in particle size and evident enhancement in the physical stability of SPI-based emulsions.	Water	47-52	chromogranin A	Homo sapiens	89-92
23544430-6	2013	A linear calibration curve for dissolved ozone in water could be achieved between concentrations of 0.49 and 740 muM, with an estimated detection limit (S/N = 3) of 0.185 muM (S/N = 3).	Water	50-55	latexin	Homo sapiens	113-116
23544430-6	2013	A linear calibration curve for dissolved ozone in water could be achieved between concentrations of 0.49 and 740 muM, with an estimated detection limit (S/N = 3) of 0.185 muM (S/N = 3).	Water	50-55	latexin	Homo sapiens	171-174
23560486-3	2013	In HepG2 cells, the Nrf2-mediated antioxidant response-measured as Nrf2 protein accumulation, expression of antioxidant response element (ARE)-regulated genes and ARE-luciferase reporter gene assays were activated by OC extracts from drinking water sources that detected 25 compounds in 9 classification groups.	Water	243-248	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
23547735-5	2013	Microwave-induced H2O/Ar plasma pretreatment of the carcinoembryonic antigen (CEA) immunosensor improved the antibody immobilization, and there was an obvious improvement in the linear detection range, i.e., 1 order of magnitude compared with a commercial enzyme-linked immunosorbent assay (ELISA).	Water	18-21	CEA cell adhesion molecule 3	Homo sapiens	52-76
23547735-5	2013	Microwave-induced H2O/Ar plasma pretreatment of the carcinoembryonic antigen (CEA) immunosensor improved the antibody immobilization, and there was an obvious improvement in the linear detection range, i.e., 1 order of magnitude compared with a commercial enzyme-linked immunosorbent assay (ELISA).	Water	18-21	CEA cell adhesion molecule 3	Homo sapiens	78-81
23547735-9	2013	This enhanced CEA immunosensor based on microwave-induced H2O/Ar plasma was demonstrated to be a sensitive tool for CEA diagnostics.	Water	58-61	CEA cell adhesion molecule 3	Homo sapiens	14-17
23547735-9	2013	This enhanced CEA immunosensor based on microwave-induced H2O/Ar plasma was demonstrated to be a sensitive tool for CEA diagnostics.	Water	58-61	CEA cell adhesion molecule 3	Homo sapiens	116-119
23537101-2	2013	Using relativistic quantum calculations, coupled to implicit solvation models, on the most stable AtO(+)(H2O)6 clusters, we demonstrate that specific interactions with water molecules of the first solvation shell induce a spin change for the AtO(+) ground state, from a spin state of triplet character in the gas phase to a Kramers-restricted closed-shell configuration in solution.	Water	168-173	splicing factor-like protein	Arabidopsis thaliana	98-101
23523120-6	2013	Water concentrations of PCBs using sediment data was found as between 0.001 and 11.0 ng L-1.	Water	0-5	immunoglobulin kappa variable 1-16	Homo sapiens	88-91
23642335-1	2013	BACKGROUND: Catalase (CAT) breaks down H2O2 into H2O and O2 to protects cells from oxidative damage.	Water	39-42	catalase	Homo sapiens	12-20
23642335-1	2013	BACKGROUND: Catalase (CAT) breaks down H2O2 into H2O and O2 to protects cells from oxidative damage.	Water	39-42	catalase	Homo sapiens	22-25
23537101-2	2013	Using relativistic quantum calculations, coupled to implicit solvation models, on the most stable AtO(+)(H2O)6 clusters, we demonstrate that specific interactions with water molecules of the first solvation shell induce a spin change for the AtO(+) ground state, from a spin state of triplet character in the gas phase to a Kramers-restricted closed-shell configuration in solution.	Water	168-173	splicing factor-like protein	Arabidopsis thaliana	242-245
23557185-2	2013	In this study, Raman spectroscopy was used to probe the hydration induced structural changes at various sites of lysozyme under isothermal conditions in the range of water contents from 0 to 44 wt %.	Water	166-171	lysozyme	Homo sapiens	113-121
23557185-9	2013	The native structure of lysozyme was achieved at 35 wt % water where its content is high enough for filling the space between lysozyme molecules.	Water	57-62	lysozyme	Homo sapiens	24-32
23557185-9	2013	The native structure of lysozyme was achieved at 35 wt % water where its content is high enough for filling the space between lysozyme molecules.	Water	57-62	lysozyme	Homo sapiens	126-134
23637307-1	2013	The cystic fibrosis transmembrane conductance regulator (CFTR) protein is highly expressed in the pancreatic duct epithelia and permits anions and water to enter the ductal lumen.	Water	147-152	CF transmembrane conductance regulator	Homo sapiens	4-55
23427142-5	2013	Water restriction (48 h) increased urine osmolarity similarly in both genotypes to 3,440 +- 220 and 3,200 +- 180 mosmol/kg in WT and WNK3-/- mice, respectively (n=11; P=0.41).	Water	0-5	WNK lysine deficient protein kinase 3	Mus musculus	133-137
28509212-3	2013	This case highlights key diagnostic and therapeutic challenges: (1) the interpretation of the response to exogenous vasopressin in a patient with steroid-induced hyperglycemia and (2) the potential risk of brain edema and herniation if excess water is prescribed along with vasopressin supplementation.	Water	243-248	arginine vasopressin	Homo sapiens	116-127
23637307-1	2013	The cystic fibrosis transmembrane conductance regulator (CFTR) protein is highly expressed in the pancreatic duct epithelia and permits anions and water to enter the ductal lumen.	Water	147-152	CF transmembrane conductance regulator	Homo sapiens	57-61
23370527-0	2013	Role of the EGF receptor in PPARgamma-mediated sodium and water transport in human proximal tubule cells.	Water	58-63	epidermal growth factor receptor	Homo sapiens	12-24
23370527-0	2013	Role of the EGF receptor in PPARgamma-mediated sodium and water transport in human proximal tubule cells.	Water	58-63	peroxisome proliferator activated receptor gamma	Homo sapiens	28-37
23370527-14	2013	CONCLUSIONS/INTERPRETATION: Our data suggest that EGFR activation mediates PPARgamma-induced sodium and water reabsorption via upregulation of NHE3 and AQP1 channels in the proximal tubule.	Water	104-109	epidermal growth factor receptor	Homo sapiens	50-54
23370527-14	2013	CONCLUSIONS/INTERPRETATION: Our data suggest that EGFR activation mediates PPARgamma-induced sodium and water reabsorption via upregulation of NHE3 and AQP1 channels in the proximal tubule.	Water	104-109	peroxisome proliferator activated receptor gamma	Homo sapiens	75-84
23515451-0	2013	An abnormal apelin/vasopressin balance may contribute to water retention in patients with the syndrome of inappropriate antidiuretic hormone (SIADH) and heart failure.	Water	57-62	arginine vasopressin	Homo sapiens	19-30
23370527-15	2013	EGFR inhibition may be a therapeutic strategy in the treatment of diabetic nephropathy and in limiting salt and water retention, which currently restricts the use of PPARgamma agonists.	Water	112-117	epidermal growth factor receptor	Homo sapiens	0-4
23466145-2	2013	Tap water samples were monthly collected from the three sampling sites with different distances of distribution network from the plant during April 2010-March 2011: Min (less than 0.1km), Mid (approximately 4km) and Max (approximately 8km).	Water	4-9	nuclear RNA export factor 1	Rattus norvegicus	0-3
23466145-4	2013	Pro-estrogenic and estrogenic activity in tap water ranged from 151.4 to 1395.6pg EEQ/L and 35.2 to 1511pg EEQ/L, respectively.	Water	46-51	nuclear RNA export factor 1	Rattus norvegicus	42-45
23007800-7	2013	The solubility of individual PCB congeners in water did not influence the desorption of PCBs from the sediment.	Water	46-51	pyruvate carboxylase	Homo sapiens	29-32
23542573-2	2013	This paper presents trigger values for the ERalpha, AR, PR, and GR CALUX bioassays for agonistic hormonal activities in (drinking) water, which define a level above which human health risk cannot be waived a priori and additional examination of specific endocrine activity may be warranted.	Water	131-136	estrogen receptor 1	Homo sapiens	43-50
23542573-7	2013	For instance, at one specific drinking water production site ERalpha and AR (but no GR and PR) activities were detected in drinking water, however, these levels are at least a factor 83 smaller than the respective trigger values, and therefore no human health risks are to be expected from hormonal activity in Dutch drinking water from this site.	Water	39-44	estrogen receptor 1	Homo sapiens	61-68
23352982-2	2013	Also, a beef-based dehydrated beef protein (DBP) water binding ingredient was evaluated.	Water	49-54	D-box binding PAR bZIP transcription factor	Homo sapiens	44-47
24218832-3	2013	Results indicated that most of the NO3(-)-N concentrations in groundwater from the agro- and forest ecosystems were below the Class 3 drinking water standard stated in the Chinese National Standard: Quality Standard for Ground Water (&lt; or = 20 mg/L).	Water	68-73	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
24218836-0	2013	Pb(II) removal from water using Fe-coated bamboo charcoal with the assistance of microwaves.	Water	20-25	submaxillary gland androgen regulated protein 3B	Homo sapiens	0-6
24218836-2	2013	The material can be used as an adsorbent for Pb(II) contaminants removal in water.	Water	76-81	submaxillary gland androgen regulated protein 3B	Homo sapiens	45-51
23532834-1	2013	Vasopressin and nonmammalian hormone vasotocin are known to increase the water permeability of mammalian collecting ducts, frog skin and the urinary bladder.	Water	73-78	arginine vasopressin	Homo sapiens	0-11
23532834-3	2013	The subject of this study was a search for vasopressin and vasotocin analogues with selective effects on renal water, sodium and potassium excretion.	Water	111-116	arginine vasopressin	Rattus norvegicus	43-54
23634216-5	2013	The reduction of camphor and simultaneous oxidation of water are likely catalyzed by the iron-oxo intermediate of P450(cam) , and we present a plausible mechanism that accounts for the 1:1 borneol:H2O2 stoichiometry we observed.	Water	55-60	calmodulin 3	Homo sapiens	114-123
23481287-2	2013	We investigated oxidation of BP-3 by aqueous ferrate(VI) (Fe(VI)) to determine reaction kinetics, identify the reaction products, and evaluate the removal efficiency of BP-3 during water treatment with Fe(VI).	Water	181-186	BP3	Homo sapiens	29-33
23481287-2	2013	We investigated oxidation of BP-3 by aqueous ferrate(VI) (Fe(VI)) to determine reaction kinetics, identify the reaction products, and evaluate the removal efficiency of BP-3 during water treatment with Fe(VI).	Water	181-186	BP3	Homo sapiens	169-173
23481287-9	2013	The removal efficiency of BP-3 by Fe(VI) treatment was dependent on coexisting constituents present in source water.	Water	110-115	BP3	Homo sapiens	26-30
23462930-6	2013	The crystal structures of all the studied hetero-trinuclear species highlight that such systems are formed thanks to the synergy between the different stereochemical requirement of the transition metal (Cu(II) or Co(II)) and the different donor atoms set of the ligands which preorganize the maltol units for the binding of the hard M(III) metal, otherwise difficult to bind in water, through L/M(II)/M(III) self-assembling.	Water	378-383	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
23528072-0	2013	One-pot synthesis of water-swellable Mg-Al layered double hydroxides and graphene oxide nanocomposites for efficient removal of As(V) from aqueous solutions.	Water	21-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	128-133
23528072-7	2013	Owing to their high uptake capability of As(V), water-swellable LDHs/GO nanocomposites are expected to have potential applications as adsorbents for As(V) polluted water cleanup.	Water	48-53	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
23528072-7	2013	Owing to their high uptake capability of As(V), water-swellable LDHs/GO nanocomposites are expected to have potential applications as adsorbents for As(V) polluted water cleanup.	Water	48-53	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	149-154
23528072-7	2013	Owing to their high uptake capability of As(V), water-swellable LDHs/GO nanocomposites are expected to have potential applications as adsorbents for As(V) polluted water cleanup.	Water	164-169	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	149-154
23149824-4	2013	Mice with the genetic deletion of Slc26a9 show significant reduction in renal chloride excretion when fed a diet high in salt or subjected to water deprivation.	Water	142-147	solute carrier family 26, member 9	Mus musculus	34-41
25123995-0	2013	[A case study regarding the technical and public health feasibility of collecting water from fog].	Water	82-87	zinc finger protein, FOG family member 1	Homo sapiens	93-96
25123995-1	2013	OBJECTIVES: Evaluating the collection of water for human consumption from fog nets in San Antonio (Cundinamarca department).	Water	41-46	zinc finger protein, FOG family member 1	Homo sapiens	74-77
25123995-2	2013	METHOD: Water was collected from fog using a prototype 6 m2sensor unit which was installed In the area for 53 days; this water was analysed to assess its quality regarding human consumption.	Water	8-13	zinc finger protein, FOG family member 1	Homo sapiens	33-36
23614431-3	2013	We then pinpoint the essential role played by the competing multipolar contributions to the vapor-liquid and the solute-liquid interface potentials in determining an important ion-specific direct electrostatic contribution to the ionic solvation free energy for SPC/E water-dominated by the quadrupolar and dipolar parts-beyond the dominant polarization one.	Water	268-273	proline rich protein gene cluster	Homo sapiens	262-265
23637886-4	2013	And H(H2O)m significantly prevented UV-induced MMP-1, COX-2, IL-6 and IL-1beta mRNA expressions in human skin in vivo.	Water	6-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
23637886-4	2013	And H(H2O)m significantly prevented UV-induced MMP-1, COX-2, IL-6 and IL-1beta mRNA expressions in human skin in vivo.	Water	6-9	interleukin 6	Homo sapiens	61-65
23637886-4	2013	And H(H2O)m significantly prevented UV-induced MMP-1, COX-2, IL-6 and IL-1beta mRNA expressions in human skin in vivo.	Water	6-9	interleukin 1 beta	Homo sapiens	70-78
23637886-5	2013	We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT cells.	Water	16-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
23637886-5	2013	We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT cells.	Water	16-19	interleukin 6	Homo sapiens	100-104
23637886-5	2013	We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT cells.	Water	16-19	mitogen-activated protein kinase 8	Homo sapiens	133-136
23637886-7	2013	In intrinsically aged skin, H(H2O)m application significantly reduced constitutive expressions of MMP-1, IL-6, and IL-1beta mRNA.	Water	30-33	interleukin 6	Homo sapiens	105-109
23637886-7	2013	In intrinsically aged skin, H(H2O)m application significantly reduced constitutive expressions of MMP-1, IL-6, and IL-1beta mRNA.	Water	30-33	interleukin 1 beta	Homo sapiens	115-123
23637886-8	2013	Additionally, H(H2O)m significantly increased procollagen mRNA and also decreased MMP-1 and IL-6 mRNA expressions in photoaged facial skin.	Water	16-19	interleukin 6	Homo sapiens	92-96
23486783-1	2013	Hydrated ionic liquids, exhibiting cold crystallisation behaviour of water molecules in a certain range of water contents, successfully dissolved cytochrome c maintaining the original spin state of heme.	Water	69-74	cytochrome c, somatic	Homo sapiens	146-158
23486783-1	2013	Hydrated ionic liquids, exhibiting cold crystallisation behaviour of water molecules in a certain range of water contents, successfully dissolved cytochrome c maintaining the original spin state of heme.	Water	107-112	cytochrome c, somatic	Homo sapiens	146-158
23613805-2	2013	CFTR mutations (F508del is the most common) lead to a decreased secretion of chloride/water, and to mucus sticky secretions, in pancreas, respiratory and gastrointestinal tracts.	Water	86-91	CF transmembrane conductance regulator	Homo sapiens	0-4
23490155-1	2013	In the continuing study directed toward the development of peroxisome proliferator-activated receptor gamma (hPPARgamma) agonist, we attempted to improve the water solubility of our previously developed hPPARgamma-selective agonist 3, which is insufficiently soluble for practical use, by employing two strategies: introducing substituents to reduce its molecular planarity and decreasing its hydrophobicity via replacement of the adamantyl group with a heteroaromatic ring.	Water	158-163	peroxisome proliferator activated receptor gamma	Homo sapiens	109-119
23490155-1	2013	In the continuing study directed toward the development of peroxisome proliferator-activated receptor gamma (hPPARgamma) agonist, we attempted to improve the water solubility of our previously developed hPPARgamma-selective agonist 3, which is insufficiently soluble for practical use, by employing two strategies: introducing substituents to reduce its molecular planarity and decreasing its hydrophobicity via replacement of the adamantyl group with a heteroaromatic ring.	Water	158-163	peroxisome proliferator activated receptor gamma	Homo sapiens	203-213
23556419-6	2013	A redetermination of the crystal structure of Ag(HPen) H2O (2) confirmed the proposed digonal AgS2 coordination environment to bridging thiolate sulfur atoms in polymeric intertwining chains forming a double helix.	Water	55-58	notch receptor 2	Homo sapiens	94-98
23557586-1	2013	The reaction of the multisite coordination ligand (LH4) with CoX2 nH2O in the presence of tetrabutylammonium hydroxide affords a series of homometallic dinuclear mixed-valence complexes, [Co(III)Co(II)(LH2)2(X)(H2O)](H2O)m (1, X = Cl and m = 4; 2, X = Br and m = 4; 3, X = NO3 and m = 3).	Water	211-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
23557586-1	2013	The reaction of the multisite coordination ligand (LH4) with CoX2 nH2O in the presence of tetrabutylammonium hydroxide affords a series of homometallic dinuclear mixed-valence complexes, [Co(III)Co(II)(LH2)2(X)(H2O)](H2O)m (1, X = Cl and m = 4; 2, X = Br and m = 4; 3, X = NO3 and m = 3).	Water	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
23557586-1	2013	The reaction of the multisite coordination ligand (LH4) with CoX2 nH2O in the presence of tetrabutylammonium hydroxide affords a series of homometallic dinuclear mixed-valence complexes, [Co(III)Co(II)(LH2)2(X)(H2O)](H2O)m (1, X = Cl and m = 4; 2, X = Br and m = 4; 3, X = NO3 and m = 3).	Water	67-70	NBL1, DAN family BMP antagonist	Homo sapiens	273-276
23500428-1	2013	Arsenic is among the most toxic elements and it commonly exists in water as arsenite (As(III)) and arsenate (As(V)) ions.	Water	67-72	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	108-114
23587362-2	2013	In this study, bovine serum albumin (BSA)-conjugated gold nanoclusters/nanoparticles were successfully synthesized in water at room temperature by a protein-directed, solution-phase, green synthetic method.	Water	118-123	albumin	Homo sapiens	22-35
23497850-6	2013	Preferential adsorption of water on the Silica hydride, Diamond hydride, UDC Cholesterol, Bidentate C18, and Phenyl hydride columns can be described by Langmuir isotherms.	Water	27-32	Bardet-Biedl syndrome 9	Homo sapiens	100-103
23364801-3	2013	Investigations into primary inherited nephrogenic diabetes insipidus (NDI) have contributed enormously to our understanding of the mechanisms of urinary concentration and identified the vasopressin receptor AVPR2, as well as the water channel aquaporin-2 (AQP2), as key players in water reabsorption in the collecting duct.	Water	229-234	arginine vasopressin receptor 2	Homo sapiens	70-73
23454461-2	2013	The effect of the reactor structure, initial pH, ZVI dosage, ultrasonic power and initial PNP concentration on the removal efficiency of PNP from water was investigated intensively.	Water	146-151	purine nucleoside phosphorylase	Homo sapiens	90-93
23454461-2	2013	The effect of the reactor structure, initial pH, ZVI dosage, ultrasonic power and initial PNP concentration on the removal efficiency of PNP from water was investigated intensively.	Water	146-151	purine nucleoside phosphorylase	Homo sapiens	137-140
23237985-2	2013	Using lysozyme as a cationic model protein these water soluble polymers efficiently self-assemble into nanocomplexes by charge attraction.	Water	49-54	lysozyme	Homo sapiens	6-14
23420844-3	2013	Homology modeling of mGluR8 transmembrane domain with rhodopsin as a template suggested the presence of a conserved water-mediated hydrogen-bonding network between helices VI and VII, which presumably constrains the receptor in an inactive conformation.	Water	116-121	rhodopsin	Homo sapiens	54-63
23517305-11	2013	The most likely site of the short H-bond in complexes of thrombin with the hirudin family of inhibitors is in the hydrophobic patch of the C-terminus of hirudin where Glu(57") and Glu(58") are embedded and interact with Arg(75) and Arg(77) and their solvate water (on thrombin).	Water	258-263	coagulation factor II, thrombin	Homo sapiens	57-65
26583539-3	2013	In this work, through high-level coupled cluster calculations (CCSD(T)/CBS), we have examined a variety of density functionals for their performances in the whole catalytic cycle of water oxidation catalyzed by mononuclear Ru-based WOCs.	Water	182-187	cystathionine beta-synthase	Homo sapiens	71-74
26583541-4	2013	The numerical performance of the SDFT has been demonstrated with the predictions of the solvation free energies of 15 molecular analogs of amino acid side chains in water represented by SPC/E, SPC, and TIP3P models.	Water	165-170	proline rich protein gene cluster	Homo sapiens	186-189
26583541-4	2013	The numerical performance of the SDFT has been demonstrated with the predictions of the solvation free energies of 15 molecular analogs of amino acid side chains in water represented by SPC/E, SPC, and TIP3P models.	Water	165-170	proline rich protein gene cluster	Homo sapiens	193-196
23651727-19	2013	It also finds that VEGF-A protein and mRNA, capillary length and water content is increased in meningiomas compared to control tissue, suggesting that VEGF-A is produced in, and possibly secreted from the meningiomas.	Water	65-70	vascular endothelial growth factor A	Homo sapiens	151-157
23184755-2	2013	In this paper the antimicrobial activity of a water soluble (gold nanoparticle)-polythiophene (AuNP-PTh) composite against common bacterial pathogens is reported.	Water	46-51	parathyroid hormone	Homo sapiens	100-103
23274929-2	2013	A brief general summary of the water models most extensively employed in MD simulations (SPC, SPC/E, TIP3P, TIP4P), indicating their most relevant pros and cons, is likewise provided.	Water	31-36	proline rich protein gene cluster	Homo sapiens	89-92
22972617-4	2013	In this work, water-soluble ions inside St. Mark"s Basilica in Venice were studied, with the aim of understanding their principal source and distribution inside the building.	Water	14-19	microtubule affinity regulating kinase 1	Homo sapiens	44-48
23274929-2	2013	A brief general summary of the water models most extensively employed in MD simulations (SPC, SPC/E, TIP3P, TIP4P), indicating their most relevant pros and cons, is likewise provided.	Water	31-36	proline rich protein gene cluster	Homo sapiens	94-97
23201051-6	2013	In water at pH 7.4, the co-polymer assembled spontaneously into 13.2+-3.1 nm micelles with a critical micelle concentration (CMC) of 36 muM.	Water	3-8	latexin	Homo sapiens	136-139
23462948-9	2013	Total adiponectin concentrations changed over time following the water control, and the response was significantly different in lean subjects compared with subjects with T2DM (P=0.04).	Water	65-70	adiponectin, C1Q and collagen domain containing	Homo sapiens	6-17
23462948-11	2013	Findings from the water control suggest differential basal regulation of total adiponectin in T2DM compared with lean controls.	Water	18-23	adiponectin, C1Q and collagen domain containing	Homo sapiens	79-90
23517550-3	2013	Recent theoretical calculations raised a new proposal that the Co(salen)(H2O)(SbF6) complex contains appreciable contribution from a Co(II)(salen( +)) electronic structure (Kochem, A.; Kanso, H.; Baptiste, B.; Arora, H.; Philouze, C.; Jarjayes, O.; Vezin, H.; Luneau, D.; Orio, M.; Thomas, F. Inorg.	Water	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
23333909-1	2013	A water-soluble polysaccharide (MHP-1) isolated from cultured Mortierella hepiali was obtained by hot-water extraction, DEAE-cellulose 52 anion-exchange, and Sephadex G-25 gel permeation chromatography.	Water	2-7	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	32-37
23333909-1	2013	A water-soluble polysaccharide (MHP-1) isolated from cultured Mortierella hepiali was obtained by hot-water extraction, DEAE-cellulose 52 anion-exchange, and Sephadex G-25 gel permeation chromatography.	Water	102-107	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	32-37
23496346-4	2013	The main cause of hyponatremia is nonosmotic secretion of arginine vasopressin with resultant electrolyte-free water retention.	Water	111-116	arginine vasopressin	Homo sapiens	67-78
23496346-5	2013	Thus, the available management for chronic hyponatremia must increase solute-free water excretion, such as occurs with blocking vasopressin receptors with selective V2 antagonists.	Water	82-87	arginine vasopressin	Homo sapiens	128-139
23798096-3	2013	The results showed that the annual concentrations of total water-soluble ions was (36.3 +/- 16.4) microg x m(-3) The three major ions SO4(2-), NH4(+) and NO3(-), accounted for 89% of the total water-soluble ions.	Water	59-64	NBL1, DAN family BMP antagonist	Homo sapiens	154-157
23798096-3	2013	The results showed that the annual concentrations of total water-soluble ions was (36.3 +/- 16.4) microg x m(-3) The three major ions SO4(2-), NH4(+) and NO3(-), accounted for 89% of the total water-soluble ions.	Water	193-198	NBL1, DAN family BMP antagonist	Homo sapiens	154-157
23181759-2	2013	In the present study, in vivo experiments using a non-invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation.	Water	126-131	insulin	Homo sapiens	257-264
23923792-9	2013	The high adsorption capability and good performance in other aspects make Zr-beta-FeOOH a potentially attractive adsorbent for the removal of both As(III) and As(V) from water.	Water	170-175	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	159-164
23415326-4	2013	Plants expressing SNAC1 displayed significantly enhanced tolerance to drought and salinity in multiple generations, and contained higher levels of water and chlorophyll in their leaves, as compared to wild type.	Water	147-152	NAC domain-containing protein 2	Zea mays	18-23
23443634-11	2013	PG administration in the drinking water significantly reduced fatty streak formation in ApoE-/- mice fed an HCD.	Water	34-39	apolipoprotein E	Mus musculus	88-92
23559583-1	2013	In the principal cells of the renal collecting duct, arginine vasopressin (AVP) stimulates the synthesis of cAMP, leading to signaling events that culminate in the phosphorylation of aquaporin-2 water channels and their redistribution from intracellular domains to the plasma membrane via vesicular trafficking.	Water	195-200	arginine vasopressin	Homo sapiens	62-73
23361938-3	2013	SOD1(G93A) mice received caffeine through drinking water from 70 days of age until death.	Water	51-56	superoxide dismutase 1, soluble	Mus musculus	0-4
23485053-9	2013	DISCUSSION: Antisense oligodeoxynucleotides targeting Cx43 reduced reactive astrocytosis and cerebral edema following TBI, indicating that Cx43 might be involved in regulating the water imbalance between brain cells.	Water	180-185	gap junction protein, alpha 1	Rattus norvegicus	54-58
23485053-9	2013	DISCUSSION: Antisense oligodeoxynucleotides targeting Cx43 reduced reactive astrocytosis and cerebral edema following TBI, indicating that Cx43 might be involved in regulating the water imbalance between brain cells.	Water	180-185	gap junction protein, alpha 1	Rattus norvegicus	139-143
23359558-4	2013	The AQP11 and AQP12 biological role remains to be fully clarified and their ability to allow transport of water is still debated.	Water	106-111	aquaporin 11	Homo sapiens	4-9
23181759-2	2013	In the present study, in vivo experiments using a non-invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation.	Water	126-131	insulin	Homo sapiens	321-328
23898632-9	2013	Three alkylbenzene compounds can be separated and retained well on C18-sph-SiON even in the mobile phase of methanol/H2O (70/30, v/v) with 78 507 plates/m, and an excellent tailing factor (0.95) can be obtained for ethylbenzene.	Water	117-120	Bardet-Biedl syndrome 9	Homo sapiens	67-70
22996620-7	2013	Moreover, a small amount of O2- induced by water extracts from fermented soy milk at low concentration (1 mg mL-1) increased the content of calcium ions and activated eNOS, thereby promoting NO production and the coupling state of eNOS.	Water	43-48	nitric oxide synthase 3	Homo sapiens	167-171
23164158-3	2013	Aquaporin 1 (AQP1) is a specific protein channels for water transport; it is expressed in articular chondrocytes, human synovitis, in chondrocytes of patients with rheumatoid arthritis or OA and in chondrocyte-like cells of human intervertebral disc.	Water	54-59	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
23164158-3	2013	Aquaporin 1 (AQP1) is a specific protein channels for water transport; it is expressed in articular chondrocytes, human synovitis, in chondrocytes of patients with rheumatoid arthritis or OA and in chondrocyte-like cells of human intervertebral disc.	Water	54-59	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
23384517-3	2013	When an initial flux of 25 L/m(2)h was applied, both flux reduction and foulant mass deposition were severe for feed water containing the mixture of LYS and ALG (e.g., 50% LYS and 50% ALG at a total foulant concentration of 100 mg/L).	Water	117-122	lysozyme	Homo sapiens	149-152
23395731-8	2013	Activation of extracellular signal-related kinase (ERK) by OGD was dependent on alpha-dystroglycan binding, and inhibition of ERK activity with U0126 abrogated the loss of water uptake following OGD.	Water	172-177	mitogen-activated protein kinase 1	Homo sapiens	14-49
23395731-8	2013	Activation of extracellular signal-related kinase (ERK) by OGD was dependent on alpha-dystroglycan binding, and inhibition of ERK activity with U0126 abrogated the loss of water uptake following OGD.	Water	172-177	mitogen-activated protein kinase 1	Homo sapiens	51-54
22996620-7	2013	Moreover, a small amount of O2- induced by water extracts from fermented soy milk at low concentration (1 mg mL-1) increased the content of calcium ions and activated eNOS, thereby promoting NO production and the coupling state of eNOS.	Water	43-48	nitric oxide synthase 3	Homo sapiens	231-235
23395731-8	2013	Activation of extracellular signal-related kinase (ERK) by OGD was dependent on alpha-dystroglycan binding, and inhibition of ERK activity with U0126 abrogated the loss of water uptake following OGD.	Water	172-177	mitogen-activated protein kinase 1	Homo sapiens	126-129
23634022-3	2013	The Pb(II) ion is coordinated in form of a distorted polyhedron by seven O atoms from four separate L (4-) ligands and by one water O atom.	Water	126-131	submaxillary gland androgen regulated protein 3B	Homo sapiens	4-10
23498120-10	2013	Finally, the sensors were applied to the determination of Cd(II) and Pb(II) ions in water samples.	Water	84-89	submaxillary gland androgen regulated protein 3B	Homo sapiens	58-75
23556701-1	2013	Water becomes ordered in the form of hexagonal ice at room temperature under controlled humidity conditions upon confinement in the nanometer range between protective graphene sheets and crystalline (111) surfaces with hexagonal symmetry of the alkali earth fluoride BaF2.	Water	0-5	BANF family member 2	Homo sapiens	267-271
23448377-2	2013	RMs in simulations have been represented by a reduced model where SPC/E water molecules interact with a trapped C153 that possesses realistic charge distributions for both ground and excited states.	Water	72-77	proline rich protein gene cluster	Homo sapiens	66-69
23461818-2	2013	In water, the D3h symmetry of NO3(-) is broken, and the degeneracy of the asymmetric-stretch modes is lifted.	Water	3-8	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
23461818-7	2013	These time scales are very similar to those reported for isotope-labeled water, suggesting that NO3(-)(aq) has a labile hydration shell.	Water	73-78	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
23413980-5	2013	Their interactions were addressed by the combined force field of ClayFF, constant-valence force field, and SPC water model.	Water	111-116	proline rich protein gene cluster	Homo sapiens	107-110
24357911-10	2013	The results of this study suggest that NIR reflectance measurements at longer near-IR wavelengths coincident with higher water absorption are better suited for imaging early caries lesions.	Water	121-126	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	39-42
23634005-1	2013	In the title compound, [Co(C7H4ClO2)2(C5H5N)2(H2O)], the Co(II) atom is six-coordinated by three O atoms from a bidentate and a monodentate 4-chloro-benzoate ligand, two N atoms from two pyridine ligands and a water O atom, giving a distorted octa-hedral geometry.	Water	210-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
23159147-2	2013	After ingestion of contaminated food or water, ETEC bacteria colonize the small intestine where they produce heat-labile (LT) and/or heat-stable (ST) enterotoxins, which induce watery diarrhea.	Water	40-45	ETEC	Sus scrofa	47-51
23413217-1	2013	RATIONALE: The absence of an agreed-upon delta(17)O value for the primary reference water SLAP leads to significant discrepancies in the reported values of delta(17)O and the parameter (17)O(excess).	Water	84-89	Src like adaptor	Homo sapiens	90-94
23432372-4	2013	To investigate this mechanism in further detail, we performed all-atom molecular dynamics (MD) simulations and replica-exchange MD (REMD) simulations of the Tom20-presequence complex in explicit water.	Water	195-200	translocase of outer mitochondrial membrane 20	Homo sapiens	157-162
32260802-0	2013	PEGylated denatured bovine serum albumin modified water-soluble inorganic nanocrystals as multifunctional drug delivery platforms.	Water	50-55	albumin	Homo sapiens	27-40
23814506-6	2013	Using this model as a base Hamiltonian, the new mDC approach is applied to a series of water systems, where results show that geometries and interaction energies between water molecules are greatly improved relative to full DFTB2.	Water	87-92	chemokine (C-C motif) ligand 22	Mus musculus	48-51
23814506-6	2013	Using this model as a base Hamiltonian, the new mDC approach is applied to a series of water systems, where results show that geometries and interaction energies between water molecules are greatly improved relative to full DFTB2.	Water	170-175	chemokine (C-C motif) ligand 22	Mus musculus	48-51
23402521-3	2013	Complete deuteration effects on amidic groups were revealed through the analysis of the amide I band of lysozyme dissolved in deuterated water.	Water	137-142	lysozyme	Homo sapiens	104-112
23534665-2	2013	As ionic solutes we consider a F(-) and a Na(+) ion, as an example for a polar molecule with vanishing net charge we take a SPC/E water molecule.	Water	130-135	proline rich protein gene cluster	Homo sapiens	124-127
23534665-7	2013	On the other hand, the heat capacity of the overall charge-neutral polar solute derived from a SPC/E water molecule is positive for all charge scaling factors considered by us.	Water	101-106	proline rich protein gene cluster	Homo sapiens	95-98
23344965-1	2013	Subtle differences in metal-ligand bond lengths between a series of [M(4)L(6)](4-) tetrahedral cages, where M = Fe(II), Co(II), or Ni(II), were observed to result in substantial differences in affinity for hydrophobic guests in water.	Water	228-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
23404086-0	2013	Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions.	Water	73-78	MIS18 kinetochore protein A	Homo sapiens	24-27
23394469-4	2013	For the met-enkephalin pentapeptide at a water-graphite interface, we were able to obtain accurate predictions for the location of the adsorbed peptide and its free energy of adsorption from around 50 and 80 SMD simulations, respectively.	Water	41-46	proopiomelanocortin	Homo sapiens	8-22
23219802-5	2013	Mass spectrometry of the isolated, high molecular, cross-linked stomatin complexes revealed the major interaction partners as glucose transporter-1 (GLUT1), anion exchanger (band 3), and water channel (aquaporin-1).	Water	187-192	stomatin	Homo sapiens	64-72
23219802-5	2013	Mass spectrometry of the isolated, high molecular, cross-linked stomatin complexes revealed the major interaction partners as glucose transporter-1 (GLUT1), anion exchanger (band 3), and water channel (aquaporin-1).	Water	187-192	aquaporin 1 (Colton blood group)	Homo sapiens	202-213
23997756-5	2013	While VP conserves water and increases circulating blood volume, OT eliminates sodium.	Water	19-24	arginine vasopressin	Homo sapiens	6-8
23463968-1	2013	Patients with heart failure often show increased arginine vasopressin secretion and enhanced sympathetic and renin-angiotensin-aldosterone activation, which accelerate renal water reabsorption, causing water retention and volume overload.	Water	174-179	renin	Homo sapiens	109-114
23463968-1	2013	Patients with heart failure often show increased arginine vasopressin secretion and enhanced sympathetic and renin-angiotensin-aldosterone activation, which accelerate renal water reabsorption, causing water retention and volume overload.	Water	202-207	renin	Homo sapiens	109-114
23463968-2	2013	Tolvaptan is an orally active antagonist of arginine vasopressin type 2 receptors in the collecting duct of the kidney that inhibits water reabsorption without substantially affecting the electrolyte balance.	Water	133-138	arginine vasopressin	Homo sapiens	53-64
23201044-5	2013	The remaining water and milk isolates showed variable presence of inlJ, plcA, prfA, and iap genes.	Water	14-19	alkaline phosphatase, intestinal	Homo sapiens	88-91
23404086-0	2013	Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions.	Water	73-78	insulin	Homo sapiens	44-51
23404086-0	2013	Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions.	Water	86-91	MIS18 kinetochore protein A	Homo sapiens	24-27
23404086-0	2013	Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions.	Water	86-91	insulin	Homo sapiens	44-51
23440275-0	2013	Regulation of AQP0 water permeability is enhanced by cooperativity.	Water	19-24	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	14-18
23497963-1	2013	Ascites formation in patients with cirrhosis, portal hypertension, or both usually results from hyperdynamic circulatory dysfunction, where the retention of sodium and water is associated with the activation of the sympathetic and renin-angiotensin-aldosterone systems.	Water	168-173	renin	Homo sapiens	231-236
23313003-5	2013	Milk is a complex biological matrix containing large amounts of water, fat, and protein.	Water	64-69	Weaning weight-maternal milk	Bos taurus	0-4
23440275-1	2013	Aquaporin 0 (AQP0), essential for lens clarity, is a tetrameric protein composed of four identical monomers, each of which has its own water pore.	Water	135-140	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	0-11
23440275-1	2013	Aquaporin 0 (AQP0), essential for lens clarity, is a tetrameric protein composed of four identical monomers, each of which has its own water pore.	Water	135-140	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	13-17
23440275-2	2013	The water permeability of AQP0 expressed in Xenopus laevis oocytes can be approximately doubled by changes in calcium concentration or pH.	Water	4-9	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	26-30
23440275-6	2013	Because the concentrations of calcium and hydrogen ions increase toward the center of the lens, a concentration signal could trigger a regulatory change in AQP0 water permeability.	Water	161-166	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	156-160
23440275-7	2013	It thus seems plausible that the cooperative modes of water permeability regulation by AQP0 tetramers mediated by decreased pH and elevated calcium are the physiologically important ones in the living lens.	Water	54-59	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	87-91
23002791-9	2013	Intracerebroventricular injection of Ang II led to a similar increase in sodium and water intake in the control and low-sodium diet groups.	Water	84-89	angiotensinogen	Rattus norvegicus	37-43
23437791-0	2013	Pu-erh tea hot-water extract activates Akt and induces insulin-independent glucose transport in rat skeletal muscle.	Water	15-20	AKT serine/threonine kinase 1	Rattus norvegicus	39-42
23371487-0	2013	IR-ATR chemical sensors based on planar silver halide waveguides coated with an ethylene/propylene copolymer for detection of multiple organic contaminants in water.	Water	159-164	ATR serine/threonine kinase	Homo sapiens	3-6
23631254-29	2013	AQP-9 is an aquaglyceroporin that allows solutes such as lactate rather than water to cross the cell membrane.	Water	77-82	aquaporin 9	Homo sapiens	0-5
23262302-6	2013	Molecular docking revealed that two "water bridges" located at the two wings of Bis-Mep stabilized its interaction with both catalytic and peripheral anionic sites of AChE.	Water	37-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	167-171
23398174-7	2013	When not bound to membrane, oxidized Met1 and Met5 of alphaS are excellent substrates for methionine sulfoxide reductase (Msr), thereby providing an efficient vehicle for water-soluble Msr enzymes to protect the membrane against oxidative damage.	Water	171-176	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	90-120
23398174-7	2013	When not bound to membrane, oxidized Met1 and Met5 of alphaS are excellent substrates for methionine sulfoxide reductase (Msr), thereby providing an efficient vehicle for water-soluble Msr enzymes to protect the membrane against oxidative damage.	Water	171-176	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	122-125
23398174-7	2013	When not bound to membrane, oxidized Met1 and Met5 of alphaS are excellent substrates for methionine sulfoxide reductase (Msr), thereby providing an efficient vehicle for water-soluble Msr enzymes to protect the membrane against oxidative damage.	Water	171-176	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	185-188
23654099-7	2013	Compared to the control area, the concentration of DEP and DBP in drinking water were significant higher in the polluted area than that in control area (P &lt; 0.05).	Water	75-80	D-box binding PAR bZIP transcription factor	Homo sapiens	59-62
23360616-10	2013	Relative to that of an unmodified duplex, the thermally induced unfolding of the duplexes with centrally positioned Sp-R and Sp-S lesions into single strands is accompanied by a smaller release of cationic counterions (Deltan(Na+) = 0.6 mol of Na+/mol of duplex) and water molecules (Deltan(w) = 17 mol of H2O/mol of duplex).	Water	267-272	sepiapterin reductase	Mus musculus	116-120
23360616-10	2013	Relative to that of an unmodified duplex, the thermally induced unfolding of the duplexes with centrally positioned Sp-R and Sp-S lesions into single strands is accompanied by a smaller release of cationic counterions (Deltan(Na+) = 0.6 mol of Na+/mol of duplex) and water molecules (Deltan(w) = 17 mol of H2O/mol of duplex).	Water	306-309	sepiapterin reductase	Mus musculus	116-120
23343309-5	2013	The results of the study on the quinoxaline   (H(2)O)(n) show that the preferred adducts in vacuo involve one, two, or three water molecules hydrogen bonded to the N atom and the neighboring H atom of the C(sp2)-H group.	Water	125-130	Sp2 transcription factor	Homo sapiens	205-210
23406108-4	2013	The results suggest that SPC/E and SWM4_DP water models yield very similar predictions for the water structural properties on neutral non-polarizable graphene, although they yield slightly different dynamical properties of interfacial water on neutral non-polarizable graphene.	Water	95-100	proline rich protein gene cluster	Homo sapiens	25-28
23125284-1	2013	The mitochondrial respiratory chain complex IV (cytochrome c oxidase) is a multi-subunit enzyme that transfers electrons from cytochrome c to molecular oxygen, yielding water.	Water	169-174	cytochrome c, somatic	Homo sapiens	48-60
23125284-1	2013	The mitochondrial respiratory chain complex IV (cytochrome c oxidase) is a multi-subunit enzyme that transfers electrons from cytochrome c to molecular oxygen, yielding water.	Water	169-174	cytochrome c, somatic	Homo sapiens	126-138
26281751-5	2013	When water vapor was present, a faster NO3(-) conversion occurred, leading to a net loss of surface-bound nitrogenated species.	Water	5-10	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
23294322-1	2013	We use transition path sampling to study evaporation in the SPC/E model of liquid water.	Water	82-87	proline rich protein gene cluster	Homo sapiens	60-63
23406108-4	2013	The results suggest that SPC/E and SWM4_DP water models yield very similar predictions for the water structural properties on neutral non-polarizable graphene, although they yield slightly different dynamical properties of interfacial water on neutral non-polarizable graphene.	Water	95-100	proline rich protein gene cluster	Homo sapiens	25-28
23384353-3	2013	Adrenocorticotropic hormone concentration in serum was highest for chicks fed the GABA-deficient water and was significantly decreased by the supplement of GABA at days 1, 3 and 5 after beak trimming (P &lt; 0.05).	Water	97-102	proopiomelanocortin	Homo sapiens	0-27
23442910-1	2013	The hydrophobic surfactant proteins, SP-B and SP-C, greatly accelerate the adsorption of the surfactant lipids to an air/water interface.	Water	121-126	surfactant protein C	Homo sapiens	46-50
23305173-1	2013	Water-soluble gold nanorods (Au NRs) have been functionalized with an N-alkylaminopyrazole ligand, 1-[2-(octylamino)ethyl]-3,5-diphenylpyrazole (PyL), that has been demonstrated able to coordinate heavy metal ions.	Water	0-5	secreted frizzled related protein 4	Homo sapiens	145-148
23645964-2	2013	The efficacy of these materials in removal of arsenate (As(V) ) from water was assessed.	Water	69-74	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	56-61
22975281-8	2013	We performed an in-depth analysis of the translocation of water in the Abeta(42)-bilayer systems.	Water	58-63	amyloid beta precursor protein	Homo sapiens	71-76
22975281-12	2013	The beta-sheet tetramer allows more water molecules to pass through the bilayer compared to monomeric Abeta, allowing us to conclude that the experimentally observed permeabilization of membranes must be due to membrane-bound Abeta oligomers, and not monomers.	Water	36-41	amyloid beta precursor protein	Homo sapiens	226-231
23404569-0	2013	The effect of complex solvents on the structure and dynamics of protein solutions: The case of Lysozyme in trehalose/water mixtures.	Water	117-122	lysozyme	Homo sapiens	95-103
23180052-3	2013	In the kidney, Ang II stimulates renal tubular water and salt reabsorption causing antinatriuresis and antidiuresis.	Water	47-52	angiotensinogen	Homo sapiens	15-21
23620122-3	2013	Apolipoprotein E knockout mice were administered EGCG or vehicle in drinking water; they were then fed high-fat diets and injected with P. gingivalis three times a week for 3 weeks.	Water	77-82	apolipoprotein E	Mus musculus	0-16
23404385-2	2013	Numerous reports suggest that cytochrome P4503A5 (CYP3A5) catalyzes 6beta-hydroxylation of endogenous cortisol (CS), which is associated with sodium and water retention in the kidney and involved in the regulation of blood pressure.	Water	153-158	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	50-56
23161028-2	2013	The water-soluble FliH(X)-FliI(6) ATPase ring complex allows FliJ to efficiently interact with FlhA.	Water	4-9	FLII actin remodeling protein	Homo sapiens	26-30
23165961-1	2013	Sap is a plant fluid that primarily consists of water and small amounts of mineral elements, sugars, hormones and other nutrients.	Water	48-53	SH2 domain containing 1A	Mus musculus	0-3
22532499-0	2013	Effect of water extracts from edible Myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-alpha-treated FL83B mouse hepatocytes.	Water	10-15	tumor necrosis factor	Mus musculus	132-141
23184230-3	2013	We found that ahk1 mutants in either the Arabidopsis Nossen-0 or Columbia-0 background had increased stomatal density and stomatal index consistent with greater transpirational water loss.	Water	177-182	histidine kinase 1	Arabidopsis thaliana	14-18
23011876-6	2013	Moreover, our study reveals that the structural, dynamical, and vibrational properties of the hydration water of lysozyme are less sensitive to pressure than those of bulk water, thereby evidencing the strong influence of the protein surface on hydration water.	Water	104-109	lysozyme	Homo sapiens	113-121
23011876-6	2013	Moreover, our study reveals that the structural, dynamical, and vibrational properties of the hydration water of lysozyme are less sensitive to pressure than those of bulk water, thereby evidencing the strong influence of the protein surface on hydration water.	Water	172-177	lysozyme	Homo sapiens	113-121
23011876-6	2013	Moreover, our study reveals that the structural, dynamical, and vibrational properties of the hydration water of lysozyme are less sensitive to pressure than those of bulk water, thereby evidencing the strong influence of the protein surface on hydration water.	Water	172-177	lysozyme	Homo sapiens	113-121
23184230-13	2013	More rapid transpiration and water depletion can also explain the previously reported sensitivity of ahk1 to uncontrolled soil drying.	Water	29-34	histidine kinase 1	Arabidopsis thaliana	101-105
23136001-1	2013	The peptide hormone arginine vasopressin (AVP) plays a critical role in regulating salt and water transport in the mammalian kidney.	Water	92-97	arginine vasopressin	Homo sapiens	29-40
23272695-7	2013	The resulting nanoporous polyethylene showed an improved water uptake as a result of the hydrophilic PMe(OE)(x)MA on the pore walls.	Water	57-62	cystatin B	Homo sapiens	101-104
23113556-1	2013	Human aquaporin-1 (hAQP1) is a water channel found in many tissues and potentially involved in several human pathologies.	Water	31-36	aquaporin 1 (Colton blood group)	Homo sapiens	6-17
23113556-1	2013	Human aquaporin-1 (hAQP1) is a water channel found in many tissues and potentially involved in several human pathologies.	Water	31-36	aquaporin 1 (Colton blood group)	Homo sapiens	19-24
23113556-4	2013	In this study we present three novel hAQP1 blockers that have been identified by virtual screening and inhibit water flux through hAQP1 in Xenopus laevis oocyte swelling assays at low micromolar concentrations.	Water	111-116	aquaporin 1 (Colton blood group)	Homo sapiens	37-42
23113556-4	2013	In this study we present three novel hAQP1 blockers that have been identified by virtual screening and inhibit water flux through hAQP1 in Xenopus laevis oocyte swelling assays at low micromolar concentrations.	Water	111-116	aquaporin 1 (Colton blood group)	Homo sapiens	130-135
23252340-1	2013	Synthesized siderite was used to remove As(III) and As(V) from water solutions under anoxic conditions and oxic conditions.	Water	63-68	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	52-57
23237229-13	2013	Lys(Dap)-precursors allow high-yield (99m)Tc-labeling with [(99m)Tc(OH(2))(3)(CO)(3)](+), forming small and hydrophilic complexes, which in turn leads to peptide radiopharmaceuticals with excellent in vivo characteristics.	Water	68-73	death-associated protein	Mus musculus	4-7
23018124-8	2013	E3 mice are more susceptible than E2 or E4 mice to impairments in spatial memory retention in the water maze, indicating that apoE isoform modulates the CNS risk following space missions.	Water	98-103	apolipoprotein E	Mus musculus	126-130
23172354-4	2013	[Fe(II)(BP1)] catalyzed the oxidation of o-phenylenediamine with H(2)O(2) with enzyme-like kinetics (k(cat) = 1.0 min(-1), K(M) = 1.5 mM, k(cat)/k(uncat) = 90 000) and multiple turnover, while Fe(2+) or [Fe(bipy)(3)](2+) were inactive.	Water	65-70	BP1	Homo sapiens	8-11
23195599-1	2013	Aiming at reusing the SPC to save water resource and heat energy, a combination treatment process of UF/NF was applied to remove inorganic irons, suspended particles and little amount of organic contaminants in this article.	Water	34-39	proline rich protein gene cluster	Homo sapiens	22-25
23099248-1	2013	Amphiphilic block copolymers of the poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) family (commercially available as Pluronics or Poloxamers) are well-known for self-assembling in water (selective solvent for PEO) into micelles with a PPO-rich core and a hydrated PEO corona.	Water	186-191	protoporphyrinogen oxidase	Homo sapiens	84-87
23188468-2	2013	While experimental data show vasopressin V(1A) receptors to regulate aquaporin (AQP)4 water channel dependent brain water movement, the specific role in vasogenic and cytotoxic edema formation remains unclear.	Water	86-91	arginine vasopressin	Rattus norvegicus	29-40
23332061-9	2013	Predicted pressure, volume, and permeability changes indicate that hAQP1 water channels can transit from a high-water-permeability state to a closed state.	Water	73-78	aquaporin 1 (Colton blood group)	Homo sapiens	67-72
23332061-9	2013	Predicted pressure, volume, and permeability changes indicate that hAQP1 water channels can transit from a high-water-permeability state to a closed state.	Water	112-117	aquaporin 1 (Colton blood group)	Homo sapiens	67-72
23295480-7	2013	This study revealed successful lysozyme phasing by SAD using laboratory-source data involving Eu ions, which are mainly coordinated by the side chains of Asn46, Asp52 and Asp101 together with some water molecules.	Water	197-202	lysozyme	Homo sapiens	31-39
23320702-1	2013	We develop force field parameters for the divalent cations Mg(2+), Ca(2+), Sr(2+), and Ba(2+) for molecular dynamics simulations with the simple point charge-extended (SPC/E) water model.	Water	175-180	proline rich protein gene cluster	Homo sapiens	168-171
23336033-6	2013	Structure-activity relationships were further established, including a thermodynamic analysis of binding site water molecules, offering a structural explanation for the selective DYRK inhibition.	Water	110-115	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	179-183
23188468-2	2013	While experimental data show vasopressin V(1A) receptors to regulate aquaporin (AQP)4 water channel dependent brain water movement, the specific role in vasogenic and cytotoxic edema formation remains unclear.	Water	116-121	arginine vasopressin	Rattus norvegicus	29-40
23104315-0	2013	An innovative bovine odorant binding protein-based filtering cartridge for the removal of triazine herbicides from water.	Water	115-120	odorant-binding protein	Bos taurus	21-44
23336516-1	2013	Natural product Tanshinone IIA (TanIIA) induces apoptosis and differentiation in hepatocellular carcinoma (HCC) cells, but its clinical use is limited due to poor water solubility and lack of appropriate formulations for drug delivery.	Water	163-168	ATPase, class II, type 9A	Mus musculus	27-30
23567967-0	2013	Spectroscopic studies on the interaction of a water-soluble cationic porphyrin with bovine serum albumin.	Water	46-51	albumin	Homo sapiens	91-104
23468265-1	2013	BACKGROUND: In peritoneal dialysis (PD) approximately 40% of ultrafiltration (UF) during hypertonic dwell (mini-PET test) occurs as free water transport (FWT) through water channels, mainly aquaporin-1.	Water	137-142	aquaporin 1 (Colton blood group)	Homo sapiens	190-201
23468265-1	2013	BACKGROUND: In peritoneal dialysis (PD) approximately 40% of ultrafiltration (UF) during hypertonic dwell (mini-PET test) occurs as free water transport (FWT) through water channels, mainly aquaporin-1.	Water	167-172	aquaporin 1 (Colton blood group)	Homo sapiens	190-201
23912684-1	2013	Aquaporin-3 (AQP3) plays an important role in maintaining the normal water content of the skin.	Water	69-74	aquaporin 3	Mus musculus	0-11
23912684-1	2013	Aquaporin-3 (AQP3) plays an important role in maintaining the normal water content of the skin.	Water	69-74	aquaporin 3	Mus musculus	13-17
23391911-0	2013	Effect of salts on the water sorption kinetics of dried pasta.	Water	23-28	solute carrier family 45 member 1	Homo sapiens	56-61
23176753-3	2013	Dicarba bridges were rationally introduced into minimized analogs of GAL and NPY resulting in increased alpha-helical content, in vitro metabolic stability and n-octanol/water partitioning coefficient (logD).	Water	170-175	galanin and GMAP prepropeptide	Mus musculus	69-72
23984371-8	2013	Water immersion restraint increased gastric mucosal ulcer and hemorrhage, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 levels but failed to affect mucosal lipid peroxidation and mucus secretion compared with non-WIR.	Water	0-5	tumor necrosis factor	Rattus norvegicus	74-107
23984371-8	2013	Water immersion restraint increased gastric mucosal ulcer and hemorrhage, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 levels but failed to affect mucosal lipid peroxidation and mucus secretion compared with non-WIR.	Water	0-5	interleukin 1 beta	Rattus norvegicus	109-131
23984371-8	2013	Water immersion restraint increased gastric mucosal ulcer and hemorrhage, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 levels but failed to affect mucosal lipid peroxidation and mucus secretion compared with non-WIR.	Water	0-5	interleukin 6	Rattus norvegicus	137-141
23391911-1	2013	The water sorption kinetics of dried pasta were measured in the 20-90  C range in 1.83 mol/L of NaCl and at 80  C in 1.83 mol/L of LiCl, KCl, NaBr and NaI solutions in order to elucidate the role of salt in the kinetics.	Water	4-9	solute carrier family 45 member 1	Homo sapiens	37-42
23391911-4	2013	The apparent diffusion coefficient of water into pasta was not correlated with the crystal radius of the salts, but was with the Stokes radius of the hydrated ions.	Water	38-43	solute carrier family 45 member 1	Homo sapiens	49-54
24429819-3	2013	In human and mouse intestine, the apical Na(+)/H(+) exchangers NHE2 and NHE3 affect luminal Na(+), water, and pH.	Water	99-104	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	72-76
24564410-0	2013	Structural analysis on mutation residues and interfacial water molecules for human TIM disease understanding.	Water	57-62	triosephosphate isomerase 1	Homo sapiens	83-86
22889120-10	2013	The water- or DSS-treated B1(-/-)  mice showed a decrease in occludin gene expression, which was partially prevented by the B(2)  receptor antagonist.	Water	4-9	occludin	Mus musculus	61-69
24558627-5	2013	Syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH) and hypervolemic hyponatremia caused by heart failure or cirrhosis are treated with vasopressin antagonists (vaptans) since they increase plasma sodium (Na(2+)) concentration via their aquaretic effects (augmentation of free-water clearance).	Water	295-300	arginine vasopressin	Homo sapiens	154-165
22959602-6	2013	Spatial patterns of PCBs during 2002 revealed significantly higher water contamination on the US side of the river (seasonal average mean +- standard error (SE) sum PCB concentration of 0.63 +- 0.11 ng L(-1)) compared to the Canadian side (mean +- SE sum PCB concentration of 0.09 +- 0.01 ng L(-1)).	Water	67-72	pyruvate carboxylase	Homo sapiens	20-23
23276841-1	2013	Cystic fibrosis (CF) is a life-shortening inherited disease caused by mutations in the CF transmembrane conductance regulator gene (CFTR), which encodes for the CF transmembrane conductance regulator (CFTR) ion channel that regulates chloride and water transport across the surface of epithelial cells.	Water	247-252	CF transmembrane conductance regulator	Homo sapiens	87-125
23276841-1	2013	Cystic fibrosis (CF) is a life-shortening inherited disease caused by mutations in the CF transmembrane conductance regulator gene (CFTR), which encodes for the CF transmembrane conductance regulator (CFTR) ion channel that regulates chloride and water transport across the surface of epithelial cells.	Water	247-252	CF transmembrane conductance regulator	Homo sapiens	132-136
23276841-1	2013	Cystic fibrosis (CF) is a life-shortening inherited disease caused by mutations in the CF transmembrane conductance regulator gene (CFTR), which encodes for the CF transmembrane conductance regulator (CFTR) ion channel that regulates chloride and water transport across the surface of epithelial cells.	Water	247-252	CF transmembrane conductance regulator	Homo sapiens	161-199
22959602-6	2013	Spatial patterns of PCBs during 2002 revealed significantly higher water contamination on the US side of the river (seasonal average mean +- standard error (SE) sum PCB concentration of 0.63 +- 0.11 ng L(-1)) compared to the Canadian side (mean +- SE sum PCB concentration of 0.09 +- 0.01 ng L(-1)).	Water	67-72	pyruvate carboxylase	Homo sapiens	165-168
23276841-1	2013	Cystic fibrosis (CF) is a life-shortening inherited disease caused by mutations in the CF transmembrane conductance regulator gene (CFTR), which encodes for the CF transmembrane conductance regulator (CFTR) ion channel that regulates chloride and water transport across the surface of epithelial cells.	Water	247-252	CF transmembrane conductance regulator	Homo sapiens	201-205
24033947-2	2013	Ang II type 1 receptor (AT1R) played important roles in hypertension since it binds with Ang II, controlling salt-water and blood pressure homeostasis.	Water	114-119	angiotensinogen	Rattus norvegicus	0-6
23183173-7	2013	Next, the activation of mERs with E2-BSA decreased both overnight food and water intake and analysis of drinking microstructure indicated that the decreased water intake resulted from a decrease in burst number.	Water	157-162	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	34-40
23514343-7	2013	The underfilling is sensed by the arterial baroreceptors, which activate primarily the sympathetic nervous system and renin-angiotensin-aldosterone system, as well as vasopressin, to restore the arterial filling by increasing the vascular tone and retaining sodium and water.	Water	269-274	arginine vasopressin	Homo sapiens	167-178
23176210-1	2013	The octapeptide angiotensin II (Ang II) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and also contributes to the progression of cardiovascular remodeling.	Water	105-110	angiotensinogen	Homo sapiens	16-30
23176210-1	2013	The octapeptide angiotensin II (Ang II) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and also contributes to the progression of cardiovascular remodeling.	Water	105-110	angiotensinogen	Homo sapiens	32-38
23183173-1	2013	Estradiol (E2) decreases food and water intake in a variety of species, including rats.	Water	34-39	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	11-13
23183173-5	2013	First, we found that higher doses of E2 were necessary to reduce water intake than were sufficient to reduce food intake.	Water	65-70	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	37-39
23183173-6	2013	Analysis of drinking microstructure revealed that the decrease in water intake after E2 treatment was mediated by both a decrease in burst number and burst size.	Water	66-71	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	85-87
23220642-1	2013	Based on a known nanomolar Bcl-2 homology domain 3 (BH3) mimetic 3-thiomorpholin-8-oxo-8H-acenaphtho[1,2-b] pyrrole-9-carbonitrile (S1, MW: 331), we applied a fragment-based approach to obtain BH3 mimetics with improved affinity and improved solubility in a water-ethanol (9:1) cosolvent.	Water	258-263	BCL2 apoptosis regulator	Homo sapiens	27-32
23183173-7	2013	Next, the activation of mERs with E2-BSA decreased both overnight food and water intake and analysis of drinking microstructure indicated that the decreased water intake resulted from a decrease in burst number.	Water	75-80	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	34-40
23117398-11	2013	Trail managers should consider mitigation such as water bars, culverts and avoiding building trails with steep gradients, in order to reduce loss of soils on trails and subsequent sedimentation of streams.	Water	50-55	TNF superfamily member 10	Homo sapiens	0-5
23278892-8	2013	Galectin-7 and actin were detected by immunoblot assay in the water-soluble fractions prepared from the lesional skins of two patients with primary LCA.	Water	62-67	galectin 7	Homo sapiens	0-10
23935691-0	2013	Modulation of the expression of the proinflammatory IL-8 gene in cystic fibrosis cells by extracts deriving from olive mill waste water.	Water	130-135	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
24069046-6	2013	Deep sea water-treated BMSCs showed stronger osteogenic differentiation such as BMP2, RUNX2, OPN, and OCN, and enhanced colony forming abilities, compared to the control group.	Water	9-14	bone morphogenetic protein 2	Mus musculus	80-84
24324516-5	2013	Moreover, 7,3",4"-THIF significantly reduced scratching time, transepidermal water loss, and mast cell infiltration.	Water	77-82	thioredoxin interacting protein	Mus musculus	18-22
23479768-1	2013	Guanylin (GN), uroguanylin (UGN) and the GC-C receptor have been associated with two endocrine axes: the salt and water homeostasis regulating enterorenal axis and the recently described appetite-regulating UGN/GC-C extraintestinal axis.	Water	114-119	guanylate cyclase 2c	Mus musculus	41-45
24611289-5	2013	We showed that it is possible to obtain homogeneous nanotapes in water by co-assembling PA 1 or PA 2 with the negatively charged diluent C,16-Glu-Thr-Thr-Glu-Ser (PA 3: C16-ETTES).	Water	65-70	PAXIP1 associated glutamate rich protein 1	Homo sapiens	88-92
23487912-5	2013	The total water-soluble inorganic ions in PM2.1 accounted for 61% of TSP.	Water	10-15	thrombospondin 1	Homo sapiens	69-72
23487912-6	2013	The total water-soluble inorganic ions in PM1.1 accounted for 50% and 82% in TSP and PM2.1, respectively.	Water	10-15	thrombospondin 1	Homo sapiens	77-80
23487912-7	2013	The seasonal variations of the total water-soluble inorganic ion concentration in TSP, PM2.1 and PM1.1 were the same, following the order of summer &gt; autumn &gt; springs &gt; winter.	Water	37-42	thrombospondin 1	Homo sapiens	82-85
23111628-3	2013	With this aim in mind, water-soluble conjugates between dopamine-derived melanin and bovine serum albumin (BSA) were synthesized.	Water	23-28	albumin	Homo sapiens	92-105
24163779-8	2013	The proposed method was successfully applied to the determination of Cr(VI) and Pb(II) at ultratrace levels in natural drinking water and industrial effluents wastewater of Denizli.	Water	128-133	submaxillary gland androgen regulated protein 3B	Homo sapiens	80-86
24114638-5	2013	One group received fructose (10%) in tap water for six weeks and the other one received tap water without fructose.	Water	92-97	nuclear RNA export factor 1	Rattus norvegicus	88-91
23802162-2	2013	However, high NO3-N concentrations were seen in the water after treatment.	Water	52-57	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
23476675-2	2013	Filtering and boiling tap water can lead to changes in the DBP concentrations and modify the exposure through ingestion.	Water	26-31	D-box binding PAR bZIP transcription factor	Homo sapiens	59-62
23802162-4	2013	For the HD reactor fed by water containing NO3-N, the denitrification efficiency was high (95-98%) for all NO3-N feed rates (20-40 mg/L).	Water	26-31	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
23802162-4	2013	For the HD reactor fed by water containing NO3-N, the denitrification efficiency was high (95-98%) for all NO3-N feed rates (20-40 mg/L).	Water	26-31	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
23337101-3	2013	We have also shown in immature medaka oocytes that the exogenous expression of aquaporin 3 (AQP3), a water/cryoprotectant channel, promotes the movement of water and cryoprotectants through the plasma membrane.	Water	101-106	aquaporin-3	Oryzias latipes	79-90
22928911-6	2013	Stereospecific interaction of IN with C2 domain through conserved water molecule (K109-W(II) 1-D215/D216) is observed to be unique in the simulated structure of hIMPDH-II.	Water	66-71	inosine monophosphate dehydrogenase 2	Homo sapiens	161-170
23337101-3	2013	We have also shown in immature medaka oocytes that the exogenous expression of aquaporin 3 (AQP3), a water/cryoprotectant channel, promotes the movement of water and cryoprotectants through the plasma membrane.	Water	101-106	aquaporin-3	Oryzias latipes	92-96
23573219-0	2013	Fluxes of water through aquaporin 9 weaken membrane-cytoskeleton anchorage and promote formation of membrane protrusions.	Water	10-15	aquaporin 9	Homo sapiens	24-35
23705506-1	2013	A study is reported of the functional-relevant dynamics of three typical water-soluble proteins: Calmodulin, Src-tyrosine kinase as well as repressor of Trp operon.	Water	73-78	calmodulin 1	Homo sapiens	97-107
23705506-1	2013	A study is reported of the functional-relevant dynamics of three typical water-soluble proteins: Calmodulin, Src-tyrosine kinase as well as repressor of Trp operon.	Water	73-78	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	109-112
23935474-1	2013	Group VI Ca2+-independent phospholipase A2 (iPLA2) is a water-soluble enzyme that is active when associated with phospholipid membranes.	Water	56-61	phospholipase A2 group VI	Homo sapiens	9-42
23935474-1	2013	Group VI Ca2+-independent phospholipase A2 (iPLA2) is a water-soluble enzyme that is active when associated with phospholipid membranes.	Water	56-61	phospholipase A2 group VI	Homo sapiens	44-49
24204098-7	2013	STAT3KO mice are also resistant to EAU and produced less IL-17-producing Tc17 cells.	Water	35-38	signal transducer and activator of transcription 3	Mus musculus	0-5
23681537-4	2013	The protocol takes advantage of a unique property of PLD, i.e., its ability to substitute a primary alcohol, such as 1-butanol, for water in the hydrolytic reaction.	Water	132-137	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-56
23709024-7	2013	cGKI relaxes smooth muscle tone and prevents platelet aggregation, whereas cGKII inhibits renin secretion, chloride/water secretion in the small intestine, the resetting of the clock during early night, and endochondral bone growth.	Water	116-121	protein kinase cGMP-dependent 2	Homo sapiens	75-80
23573219-5	2013	The flux of water through membrane-anchored water channels, known as aquaporins (AQPs) has recently been implicated in the regulation of cell motility, and here we provide novel evidence for the role of AQP9 in the development of various forms of membrane protrusion.	Water	12-17	aquaporin 9	Homo sapiens	203-207
23573219-7	2013	Based on this, we present a model for AQP9-induced membrane protrusion, where the interplay of water fluxes through AQP9 and actin dynamics regulate the cellular protrusive and motile activity of cells.	Water	95-100	aquaporin 9	Homo sapiens	38-42
23573219-7	2013	Based on this, we present a model for AQP9-induced membrane protrusion, where the interplay of water fluxes through AQP9 and actin dynamics regulate the cellular protrusive and motile activity of cells.	Water	95-100	aquaporin 9	Homo sapiens	116-120
23526979-5	2013	Simulation results suggest that cell nuclear plays a significant role in cryo-dehydration and would affect water/CPA concentration gradient inside the cell.	Water	107-112	carboxypeptidase A1	Homo sapiens	113-116
23527006-3	2013	Under optimal sonication conditions [soil:water ratio  =  1/8 (w/v) and power density  =  15 watt ml(-1)], the activity of alkaline phosphomonoesterase (phosphatase) in a Haplic Cambisol soil increased with sonication time in two distinct steps.	Water	42-47	alkaline phosphatase, placental	Homo sapiens	123-151
23457492-1	2013	Catalase is a key antioxidant enzyme that catalyzes the decomposition of hydrogen peroxide (H2O2) to water and oxygen, and it appears to shuttle between the cytoplasm and peroxisome via unknown mechanisms.	Water	101-106	catalase	Homo sapiens	0-8
23405179-1	2013	The sodium hydrogen exchanger isoform 3 (NHE3) mediates absorption of sodium, bicarbonate and water from renal and intestinal lumina.	Water	94-99	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	41-45
23468877-13	2013	CuSO4, a water transport inhibitor selective for AQP3, also suppressed FGF-2-induced cell migration.	Water	9-14	fibroblast growth factor 2	Homo sapiens	71-76
22996005-7	2012	This paper is a review related to the latest and most important achievements in the field of phytoremediation of water and soil contaminated with TNT, RDX and HMX.	Water	113-118	chromosome 16 open reading frame 82	Homo sapiens	146-149
23533381-5	2013	Our data suggests that combination of an EGFR inhibitor and a PPAR gamma agonist mitigates high-glucose-induced fibrosis and inflammation and reverses the upregulation of transporters and channels involved in sodium and water retention in human proximal tubule cells.	Water	220-225	peroxisome proliferator activated receptor gamma	Homo sapiens	62-72
23533381-6	2013	Hence EGFR blockade may hold promise, not only in limiting tubulointerstitial pathology in diabetic nephropathy, but also in limiting the sodium and water retention observed in patients with diabetes and exacerbated by PPAR gamma agonists.	Water	149-154	epidermal growth factor receptor	Homo sapiens	6-10
23863115-2	2013	The MD simulation was performed on AChE to obtain enzyme conformation in a water environment.	Water	75-80	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-39
23533381-5	2013	Our data suggests that combination of an EGFR inhibitor and a PPAR gamma agonist mitigates high-glucose-induced fibrosis and inflammation and reverses the upregulation of transporters and channels involved in sodium and water retention in human proximal tubule cells.	Water	220-225	epidermal growth factor receptor	Homo sapiens	41-45
22990947-11	2013	Currently, most drinking water regulations aggressively address DBP problems in public water distribution systems.	Water	25-30	D-box binding PAR bZIP transcription factor	Homo sapiens	64-67
22990947-11	2013	Currently, most drinking water regulations aggressively address DBP problems in public water distribution systems.	Water	87-92	D-box binding PAR bZIP transcription factor	Homo sapiens	64-67
23390573-1	2013	In order to investigate the cryoprotective mechanism of trehalose on proteins, we use molecular dynamics computer simulations to study the microscopic dynamics of water upon cooling in an aqueous solution of lysozyme and trehalose.	Water	163-168	lysozyme	Homo sapiens	208-216
23390573-3	2013	Comparing aqueous solutions of lysozyme with/without trehalose, we observe that the dynamics of water in the hydration layers close to the protein is dramatically slower when trehalose is present in the system.	Water	96-101	lysozyme	Homo sapiens	31-39
23390573-4	2013	We also analyze the structure of water and trehalose around the lysozyme and find that the trehalose molecules form a cage surrounding the protein that contains very slow water molecules.	Water	33-38	lysozyme	Homo sapiens	64-72
23390573-4	2013	We also analyze the structure of water and trehalose around the lysozyme and find that the trehalose molecules form a cage surrounding the protein that contains very slow water molecules.	Water	171-176	lysozyme	Homo sapiens	64-72
23405272-1	2013	We demonstrate the ppt-level single-step selective monitoring of the presence of mercury ions (Hg2+) dissolved in environmental water by plasmon-enhanced vibrational spectroscopy.	Water	128-133	tachykinin precursor 1	Homo sapiens	19-22
23405272-5	2013	For example, with natural water from Lake Kasumigaura (Ibaraki Prefecture, Japan), direct detection of Hg2+ with a concentration as low as 37 ppt (37 x 10-10%) was readily demonstrated, indicating the high potential of this simple method for environmental and chemical sensing of metallic species in aqueous solution.	Water	26-31	tachykinin precursor 1	Homo sapiens	142-145
23244755-0	2012	A water extract of Samchulkunbi-tang attenuates airway inflammation by inhibiting inos and MMP-9 activities in an ovalbumin-induced murine asthma model.	Water	2-7	nitric oxide synthase 2, inducible	Mus musculus	82-86
23114546-0	2012	Solution mediated phase transformation (RHO to SOD) in porous Co-imidazolate based zeolitic frameworks with high water stability.	Water	113-118	rhodopsin	Homo sapiens	40-50
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Water	191-196	cystathionine beta-synthase	Homo sapiens	6-33
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Water	191-196	cystathionine beta-synthase	Homo sapiens	35-38
23124209-4	2012	The reactions of L-serine and L-cysteine with CBS resulted in the formation of a common aminoacrylate intermediate (k(obs) = 0.96 +- 0.02 and 0.38 +- 0.01 mM(-1) s(-1), respectively, at 24  C) with concomitant loss of H(2)O and H(2)S and without detectable accumulation of the external aldimine or other intermediates.	Water	218-223	cystathionine beta-synthase	Homo sapiens	46-49
23244755-0	2012	A water extract of Samchulkunbi-tang attenuates airway inflammation by inhibiting inos and MMP-9 activities in an ovalbumin-induced murine asthma model.	Water	2-7	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	114-123
23171241-6	2012	Dispersion and aggregation can also be switched on and off by choosing a polymer for which a given solvent is close to Theta-conditions, e.g., PS in cyclohexane or PPO/PEO in water.	Water	175-180	protoporphyrinogen oxidase	Homo sapiens	164-167
22975396-1	2012	We determined how glucose or insulin interacts with a phospholipid monolayer at the air/water interface and explained these mechanisms from a physico-chemical point of view.	Water	88-93	insulin	Homo sapiens	29-36
23171241-6	2012	Dispersion and aggregation can also be switched on and off by choosing a polymer for which a given solvent is close to Theta-conditions, e.g., PS in cyclohexane or PPO/PEO in water.	Water	175-180	twinkle mtDNA helicase	Homo sapiens	168-171
22999954-7	2012	The results also imply a crucial role for water in governing the productive folding reaction and enhancing the propensity for the aggregation of SOD1.	Water	42-47	superoxide dismutase 1	Homo sapiens	145-149
23093378-0	2012	Characteristics of hydration water around hen egg lysozyme as the protein model in aqueous solution.	Water	29-34	lysozyme	Homo sapiens	50-58
23108344-5	2012	Furthermore, a designed concept test shows that the as-prepared membranes could load 1.5 kg water or oil at the same time maintained an extremely high air permeability of 2 L min(-1), suggesting their use as promising materials for a variety of potential applications in protective clothing, bioseparation, water purification, tissue engineering, microfluidic systems, etc., and also provided new insight into the design and development of functional hybrid membranes based on FPU.	Water	92-97	CD59 molecule (CD59 blood group)	Homo sapiens	175-181
23093378-7	2012	Moreover, based on the difference in intermolecular distances distribution of water molecules (obtained from spectral data), we demonstrated that the lysozyme molecule causes a decrease in population of weak hydrogen bonds, and concurrently increases the probability of an occurrence of short hydrogen bonds in water affected by lysozyme.	Water	78-83	lysozyme	Homo sapiens	329-337
23140329-1	2012	Prior studies have shown that the biological mixture of the two hydrophobic surfactant proteins, SP-B and SP-C, produces faster adsorption of the surfactant lipids to an air/water interface, and that they induce 1-palmitoyl-2-oleoyl phosphatidylethanolamine (POPE) to form inverse bicontinuous cubic phases.	Water	174-179	surfactant protein C	Homo sapiens	106-110
23093378-4	2012	Analysis of spectra of HDO isotopically diluted in water solution of lysozyme allowed us to isolate HDO spectra affected by lysozyme, and thus to characterise the energetic state of water molecules and their arrangement around protein molecules.	Water	51-56	lysozyme	Homo sapiens	69-77
23093378-7	2012	Moreover, based on the difference in intermolecular distances distribution of water molecules (obtained from spectral data), we demonstrated that the lysozyme molecule causes a decrease in population of weak hydrogen bonds, and concurrently increases the probability of an occurrence of short hydrogen bonds in water affected by lysozyme.	Water	311-316	lysozyme	Homo sapiens	150-158
23093378-7	2012	Moreover, based on the difference in intermolecular distances distribution of water molecules (obtained from spectral data), we demonstrated that the lysozyme molecule causes a decrease in population of weak hydrogen bonds, and concurrently increases the probability of an occurrence of short hydrogen bonds in water affected by lysozyme.	Water	311-316	lysozyme	Homo sapiens	329-337
23093378-4	2012	Analysis of spectra of HDO isotopically diluted in water solution of lysozyme allowed us to isolate HDO spectra affected by lysozyme, and thus to characterise the energetic state of water molecules and their arrangement around protein molecules.	Water	51-56	lysozyme	Homo sapiens	124-132
23093378-4	2012	Analysis of spectra of HDO isotopically diluted in water solution of lysozyme allowed us to isolate HDO spectra affected by lysozyme, and thus to characterise the energetic state of water molecules and their arrangement around protein molecules.	Water	182-187	lysozyme	Homo sapiens	69-77
23093378-4	2012	Analysis of spectra of HDO isotopically diluted in water solution of lysozyme allowed us to isolate HDO spectra affected by lysozyme, and thus to characterise the energetic state of water molecules and their arrangement around protein molecules.	Water	182-187	lysozyme	Homo sapiens	124-132
23093378-7	2012	Moreover, based on the difference in intermolecular distances distribution of water molecules (obtained from spectral data), we demonstrated that the lysozyme molecule causes a decrease in population of weak hydrogen bonds, and concurrently increases the probability of an occurrence of short hydrogen bonds in water affected by lysozyme.	Water	78-83	lysozyme	Homo sapiens	150-158
24061374-9	2012	The experimental results of TG-DTA showed that the Co(III) complex contained ethanol and crystal water in the first two stages.	Water	97-102	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	51-58
22932685-7	2012	My laboratory is applying such an approach to the question: "How does the peptide hormone vasopressin regulate water permeability in the renal collecting duct?"	Water	111-116	arginine vasopressin	Homo sapiens	90-101
22959761-3	2012	Serum sodium concentration is linked to water homeostasis, which is dependent on the thirst mechanism, arginine vasopressin, and kidney function.	Water	40-45	arginine vasopressin	Homo sapiens	112-123
22846509-8	2012	Mutations of this construct containing zero and two tryptophan residues near the water-membrane interface resulted in changes in the positioning of n-Syb in the micelle.	Water	81-86	neuronal Synaptobrevin	Drosophila melanogaster	148-153
22540947-1	2012	The water-soluble poly(methyl vinyl ether-co-maleic anhydride) copolymer-bovine serum albumin bioconjugates were synthesized in the presence of 1-ethyl-3-(3-dimetilamino-propyl) carbodiimide hydrochloride as cross-linking agents via microwave-assisted and conventional methods and characterized by size-exclusion chromatography and high-performance liquid chromatography.	Water	4-9	albumin	Homo sapiens	80-93
22311647-2	2012	Water-forming NADH oxidase (nox-2) can catalyze the conversion of oxygen to water with concomitant NADH oxidation in anaerobic microorganisms.	Water	0-5	SagB/ThcOx family dehydrogenase	Bacillus cereus ATCC 14579	14-26
22311647-2	2012	Water-forming NADH oxidase (nox-2) can catalyze the conversion of oxygen to water with concomitant NADH oxidation in anaerobic microorganisms.	Water	76-81	SagB/ThcOx family dehydrogenase	Bacillus cereus ATCC 14579	14-26
22846509-9	2012	Moreover, the addition of a second tryptophan appears to slow dynamic motions of n-Syb near the micelle-water interface.	Water	104-109	neuronal Synaptobrevin	Drosophila melanogaster	81-86
22581747-7	2012	In addition, we found that pretreatment with the MAP kinase inhibitor U0126 completely blocked the desensitizing effect of repeated Ang II injections on water intake.	Water	153-158	angiotensinogen	Rattus norvegicus	132-138
22968041-2	2012	SCN is the preferred substrate for LPO-driven catalytic reduction of hydrogen peroxide (H(2)O(2)) forming hypothiocyanous acid (HOSCN).	Water	88-93	lactoperoxidase	Homo sapiens	35-38
22581747-1	2012	Angiotensin II (Ang II) acts on central angiotensin type 1 (AT(1)) receptors to increase water and saline intake.	Water	89-94	angiotensinogen	Rattus norvegicus	0-14
22581747-1	2012	Angiotensin II (Ang II) acts on central angiotensin type 1 (AT(1)) receptors to increase water and saline intake.	Water	89-94	angiotensinogen	Rattus norvegicus	16-22
23000573-6	2012	RESULTS: We investigated the interaction between a G-quadruplex-forming sequence in the human c-kit proto-oncogene and the water soluble porphyrin TMPyP4.	Water	123-128	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	94-114
22766279-4	2012	Moreover, the incorporation of WPU improved the water resistance and mechanical properties of SPI films, which suggested that the blend films might be used as food packaging, coating and biomedical materials instead of synthetic polymer materials.	Water	48-53	chromogranin A	Homo sapiens	94-97
22581747-3	2012	Specifically, rats given repeated injections of Ang II drink less water than control animals after a subsequent test injection of Ang II.	Water	66-71	angiotensinogen	Rattus norvegicus	48-54
22581747-3	2012	Specifically, rats given repeated injections of Ang II drink less water than control animals after a subsequent test injection of Ang II.	Water	66-71	angiotensinogen	Rattus norvegicus	130-136
22581747-8	2012	Furthermore, Ang II-induced water intake was reduced to a similar extent by repeated injections of Ang II or SII.	Water	28-33	angiotensinogen	Rattus norvegicus	13-19
22581747-5	2012	Given earlier studies indicating that separate intracellular signalling pathways mediate Ang II-induced water and saline intake, we hypothesized that the desensitization observed in rats may be incomplete, leaving the receptor able to activate mitogen-activated protein (MAP) kinases (ERK1/2), which play a role in Ang II-induced saline intake without affecting water intake.	Water	104-109	angiotensinogen	Rattus norvegicus	89-95
22581747-8	2012	Furthermore, Ang II-induced water intake was reduced to a similar extent by repeated injections of Ang II or SII.	Water	28-33	angiotensinogen	Rattus norvegicus	99-105
22941771-6	2012	The hydrophilicity of MGF-Ct24E-MPLA was evaluated by means of the water-uptake ratios and static water contact angle.	Water	67-72	insulin like growth factor 1	Homo sapiens	22-25
23036579-0	2012	Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-kappaB pathways.	Water	0-5	signal transducer and activator of transcription 3	Mus musculus	108-113
22998079-8	2012	The effects of SOD concentration on the concentration profiles of NO, O(2)( -), ONOO(-) and H(2)O(2) in eNOS coupling/uncoupling were investigated.	Water	92-97	superoxide dismutase 1	Homo sapiens	15-18
22941771-6	2012	The hydrophilicity of MGF-Ct24E-MPLA was evaluated by means of the water-uptake ratios and static water contact angle.	Water	98-103	insulin like growth factor 1	Homo sapiens	22-25
23099538-10	2012	Noteworthy, water (1)H-NMR relaxometry allowed a detailed analysis of thermodynamic properties of HSA-metal ion complexes.	Water	12-17	albumin	Homo sapiens	98-101
23247390-3	2012	In this study, we investigate the displacement of water molecules by an apolar probe in the binding pocket of two proteins, cyclin-dependent kinase 2 and tRNA-guanine transglycosylase, using the method of enveloping distribution sampling (EDS) to obtain free enthalpy differences.	Water	50-55	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	154-183
22872487-5	2012	Both AQP8 and AQP9 may play an important role in water flow both in intramembranous absorption and in placental water transfer.	Water	49-54	aquaporin 9	Homo sapiens	14-18
22814088-3	2012	Continuous drinking of oxygenated water markedly increased peripheral blood mononuclear cell proliferation, interleukin-1beta expression level and the CD4(+):CD8(+) cell ratio in pigs.	Water	34-39	interleukin-1 beta	Sus scrofa	108-125
22427315-1	2012	The anti-diuretic hormone arginine vasopressin (AVP) is released from the pituitary upon hypovolemia or hypernatremia, and regulates water reabsorption in the renal collecting duct principal cells.	Water	133-138	arginine vasopressin	Homo sapiens	35-46
22427315-1	2012	The anti-diuretic hormone arginine vasopressin (AVP) is released from the pituitary upon hypovolemia or hypernatremia, and regulates water reabsorption in the renal collecting duct principal cells.	Water	133-138	arginine vasopressin	Homo sapiens	48-51
22427315-2	2012	Binding of AVP to the arginine vasopressin receptor type 2 (AVPR2) in the basolateral membrane leads to translocation of aquaporin 2 (AQP2) water channels to the apical membrane of the collecting duct principal cells, inducing water permeability of the membrane.	Water	140-145	arginine vasopressin	Homo sapiens	11-14
22427315-2	2012	Binding of AVP to the arginine vasopressin receptor type 2 (AVPR2) in the basolateral membrane leads to translocation of aquaporin 2 (AQP2) water channels to the apical membrane of the collecting duct principal cells, inducing water permeability of the membrane.	Water	140-145	arginine vasopressin receptor 2	Homo sapiens	22-58
22427315-2	2012	Binding of AVP to the arginine vasopressin receptor type 2 (AVPR2) in the basolateral membrane leads to translocation of aquaporin 2 (AQP2) water channels to the apical membrane of the collecting duct principal cells, inducing water permeability of the membrane.	Water	140-145	arginine vasopressin receptor 2	Homo sapiens	60-65
22427315-2	2012	Binding of AVP to the arginine vasopressin receptor type 2 (AVPR2) in the basolateral membrane leads to translocation of aquaporin 2 (AQP2) water channels to the apical membrane of the collecting duct principal cells, inducing water permeability of the membrane.	Water	227-232	arginine vasopressin	Homo sapiens	11-14
22427315-2	2012	Binding of AVP to the arginine vasopressin receptor type 2 (AVPR2) in the basolateral membrane leads to translocation of aquaporin 2 (AQP2) water channels to the apical membrane of the collecting duct principal cells, inducing water permeability of the membrane.	Water	227-232	arginine vasopressin receptor 2	Homo sapiens	22-58
22427315-2	2012	Binding of AVP to the arginine vasopressin receptor type 2 (AVPR2) in the basolateral membrane leads to translocation of aquaporin 2 (AQP2) water channels to the apical membrane of the collecting duct principal cells, inducing water permeability of the membrane.	Water	227-232	arginine vasopressin receptor 2	Homo sapiens	60-65
23161856-1	2012	Aquaporin (AQP) proteins have been shown to transport water and other small molecules through biological membranes, which is crucial for plants to combat salt stress.	Water	54-59	aquaporin PIP2-7-like	Nicotiana tabacum	0-9
23161856-1	2012	Aquaporin (AQP) proteins have been shown to transport water and other small molecules through biological membranes, which is crucial for plants to combat salt stress.	Water	54-59	aquaporin PIP2-7-like	Nicotiana tabacum	11-14
22658855-6	2012	In vitro assays demonstrated that MSC-CM promoted hepatocyte proliferation and had a direct inhibitory effect on hepatocyte apoptosis induced by H(2)O(2).	Water	145-150	musculin	Rattus norvegicus	34-37
22872487-5	2012	Both AQP8 and AQP9 may play an important role in water flow both in intramembranous absorption and in placental water transfer.	Water	112-117	aquaporin 9	Homo sapiens	14-18
23130944-1	2012	Aquaporin-2 (AQP2), the vasopressin-regulated water channel of the renal collecting duct, is dysregulated in numerous disorders of water balance in people and animals, including those associated with polyuria (urinary tract obstruction, hypokalemia, inflammation, and lithium toxicity) and with dilutional hyponatremia (syndrome of inappropriate antidiuresis, congestive heart failure, cirrhosis).	Water	46-51	arginine vasopressin	Homo sapiens	24-35
23383450-11	2012	(4) Five minutes after 0.3 mA, 3.0 mA EA and 38 degrees C, 46 degrees C thermal water-bath stimulation, both mechanical and thermal pain thresholds recovered to their baseline levels in both TRPV 1 -/- and C 57 BL/6 mice.	Water	80-85	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	191-197
22963886-6	2012	Acid-exposure increased whole body cortisol levels and translational knockdown of GR using antisense morpholinos prevented the full induction of Na(+) uptake during exposure to acidic water, further confirming the role of cortisol and GR in Na(+) uptake stimulation.	Water	184-189	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	Danio rerio	82-84
23193159-8	2012	Although reintroduction of Pin1 into the Pin1(-/-) MEFs reduced the amount of PtdIns5P produced in response to H(2)O(2), in vitro assays indicated that the isomerase activity of Pin1 inhibited PIP4K activity.	Water	111-116	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	27-31
23122813-3	2012	As we have shown previously, FS in cold water induced a significant increase in the level of tyrosine phosphorylation of SIRPalpha, a neuronal membrane protein, in mouse hippocampus, while such effect of FS was markedly reduced in mice subjected to FS in warm water.	Water	40-45	signal-regulatory protein alpha	Mus musculus	121-130
23122813-4	2012	FS in cold water also induced phosphorylation of mitogen-activated protein kinase kinase (MEK) as well as of cAMP response element-binding protein (CREB), or dephosphorylation of alpha isoform of Ca(2+)/calmodulin-dependent protein kinase II (alphaCaMKII) in the hippocampus.	Water	11-16	cAMP responsive element binding protein 1	Mus musculus	109-146
23122813-4	2012	FS in cold water also induced phosphorylation of mitogen-activated protein kinase kinase (MEK) as well as of cAMP response element-binding protein (CREB), or dephosphorylation of alpha isoform of Ca(2+)/calmodulin-dependent protein kinase II (alphaCaMKII) in the hippocampus.	Water	11-16	cAMP responsive element binding protein 1	Mus musculus	148-152
23026079-2	2012	Injection of AngII into the lateral ventricle (LV) increases water intake, but a similar response is not observed after injection into the 4V.	Water	61-66	angiotensinogen	Rattus norvegicus	13-18
23181054-8	2012	Furthermore, the inhibitory actions of ODN on the deleterious effects of H(2)O(2) on SOD and catalase were abrogated by the metabotropic ODN receptor antagonist cyclo(1-8)[Dleu(5)]OP, but not by the CBR antagonist flumazenil.	Water	73-78	catalase	Rattus norvegicus	93-101
22982576-8	2012	Under physiological pH and concentrations of halides (100muM KBr, 100muM KSCN, and 100mM NaCl), VPO1 utilizes approximately 45% of H(2)O(2) for the generation of hypobromous acid, 35% for hypothiocyanous acid, and 18% for hypochlorous acid.	Water	131-136	peroxidasin	Homo sapiens	96-100
23018861-4	2012	The congested interface led to protein unfolding, which resulted in a 56-fold higher peroxidase activity of cyt c than that in water.	Water	127-132	cytochrome c, somatic	Homo sapiens	108-113
22982576-3	2012	Phagocyte-derived myeloperoxidase (MPO) utilizes chloride and bromide, in the presence of hydrogen peroxide (H(2)O(2)), to generate hypochlorous acid and hypobromous acid, potent oxidizing species that are known to kill invading pathogens.	Water	109-114	myeloperoxidase	Homo sapiens	35-38
22982576-7	2012	VPO1, like MPO but unlike lactoperoxidase, is able to generate hypochlorous acid, hypobromous acid, and hypothiocyanous acid in the presence of H(2)O(2).	Water	144-149	peroxidasin	Homo sapiens	0-4
22998222-11	2012	This can mean that in the quasi-fully charged PSS at f = 0.82 there are still hydrophobic effects in water, which is disagreeing with our recent reports, or that the electrostatics contribution to the upturn is reduced due to a lower dielectric permittivity.	Water	101-106	PSS	Homo sapiens	46-49
22995906-5	2012	We found from the simulation of the CB1-SR141716A complex that SR141716A projects toward TM5 to interact tightly with the major binding pocket, replacing the coordinated water molecules, and secures the Trp-356(6.48) rotameric switch in the inactive state to promote the formation of an extensive water-mediated H-bonding network to the highly conserved SLAXAD and NPXXY motifs in TM2/TM7.	Water	170-175	cannabinoid receptor 1	Homo sapiens	36-39
23112160-4	2012	The magnitude of the water-exchange rate is different for simulations run using different water models [i.e., extended simple point charge (SPC/E) vs. four-site transferrable intermolecular potential (TIP4P)]; however, the value of the mass exponent gamma is the same.	Water	21-26	proline rich protein gene cluster	Homo sapiens	140-143
22765982-8	2012	In this study, female rats drink NP water during pregnancy and lactation conferred F(1) generation: (1) increase the corticosterone, aldosterone concentration in plasma; (2) increase 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity in liver and adipose tissue; (3) increase aldosterone synthase activity in adrenal for adult offspring.	Water	36-41	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	183-238
23082933-4	2012	Here, we used dialysis to reproducibly form planar and vesicular BCP membranes with a high density of reconstituted aquaporin-0 (AQP0) water channels.	Water	135-140	major intrinsic protein of lens fiber	Homo sapiens	116-127
23082933-4	2012	Here, we used dialysis to reproducibly form planar and vesicular BCP membranes with a high density of reconstituted aquaporin-0 (AQP0) water channels.	Water	135-140	major intrinsic protein of lens fiber	Homo sapiens	129-133
23068094-11	2012	In addition, H(2)O(2) increased glucose uptake in podocytes (from 0.88 +- 0.04 to 1.29 +- 0.12 nmol/min/mg protein, P&lt;0.05), and this effect was attenuated by Compound C. Our results suggested that H(2)O(2) activated the insulin signaling pathway and glucose uptake via AMPK in cultured rat podocytes.	Water	13-18	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	273-277
22995906-5	2012	We found from the simulation of the CB1-SR141716A complex that SR141716A projects toward TM5 to interact tightly with the major binding pocket, replacing the coordinated water molecules, and secures the Trp-356(6.48) rotameric switch in the inactive state to promote the formation of an extensive water-mediated H-bonding network to the highly conserved SLAXAD and NPXXY motifs in TM2/TM7.	Water	297-302	cannabinoid receptor 1	Homo sapiens	36-39
24900570-6	2013	A model, which correlates the computed solvation free energy differences obtained in water and chloroform with Pgp-mediated efflux (in logarithmic scale), was successful in predicting Pgp efflux ratios for a wide range of chemically diverse compounds with a R(2) and root-mean-square error of 0.65 and 0.29, respectively.	Water	85-90	ATP binding cassette subfamily B member 1	Homo sapiens	111-114
22995181-3	2012	It was shown that (1) Preconditioning with H(2)O(2) at 100 mumol/L for 90 min in PC12 cells induced significant expression of iNOS and COX-2.	Water	43-48	nitric oxide synthase 2	Rattus norvegicus	126-130
22995181-4	2012	(2) Pretreatment with the iNOS inhibitor AG (10 mumol/L) or the COX-2 inhibitor NS-398 (10 mumol/L) respectively 20min before H(2)O(2) preconditioning not only inhibits the increased expression of iNOS or COX-2 but also abrogates the protective effects of H(2)O(2) preconditioning against apoptosis induced by oxidative stress.	Water	256-261	nitric oxide synthase 2	Rattus norvegicus	26-30
22986411-0	2012	An unusual double T5(2) water tape trapped in silver(I) coordination polymer hosts: influence of the solvent on the assembly of Ag(I)-4,4"-bipyridine chains with trans-cyclohexanedicarboxylate and their luminescent properties.	Water	24-29	PPP1R2C family member C	Homo sapiens	128-135
23046186-5	2012	Purified CRP was digested with trypsin and subjected to high-performance LC with an optimal mobile phase of acetonitrile-water containing 0.1% formic acid (50:50, v/v) and an optimal mobile phase flow rate of 0.2 mL/min.	Water	121-126	C-reactive protein	Homo sapiens	9-12
24900570-6	2013	A model, which correlates the computed solvation free energy differences obtained in water and chloroform with Pgp-mediated efflux (in logarithmic scale), was successful in predicting Pgp efflux ratios for a wide range of chemically diverse compounds with a R(2) and root-mean-square error of 0.65 and 0.29, respectively.	Water	85-90	ATP binding cassette subfamily B member 1	Homo sapiens	184-187
23088314-1	2012	Water-soluble fac-[Re(CO)(3)(L,L"-Bid)(X)] (L,L"-Bid = tropolonato, X = H(2)O, methanol) complexes have been synthesized, and the aqua and methanol substitution reactions were investigated in water (pH range 6.3-10.0) and methanol, respectively, and compared.	Water	0-5	FA complementation group C	Homo sapiens	14-17
23088314-1	2012	Water-soluble fac-[Re(CO)(3)(L,L"-Bid)(X)] (L,L"-Bid = tropolonato, X = H(2)O, methanol) complexes have been synthesized, and the aqua and methanol substitution reactions were investigated in water (pH range 6.3-10.0) and methanol, respectively, and compared.	Water	0-5	BH3 interacting domain death agonist	Homo sapiens	34-37
23088314-1	2012	Water-soluble fac-[Re(CO)(3)(L,L"-Bid)(X)] (L,L"-Bid = tropolonato, X = H(2)O, methanol) complexes have been synthesized, and the aqua and methanol substitution reactions were investigated in water (pH range 6.3-10.0) and methanol, respectively, and compared.	Water	0-5	BH3 interacting domain death agonist	Homo sapiens	49-52
23088314-1	2012	Water-soluble fac-[Re(CO)(3)(L,L"-Bid)(X)] (L,L"-Bid = tropolonato, X = H(2)O, methanol) complexes have been synthesized, and the aqua and methanol substitution reactions were investigated in water (pH range 6.3-10.0) and methanol, respectively, and compared.	Water	192-197	FA complementation group C	Homo sapiens	14-17
22750290-3	2012	Here we found that a water-soluble pyrrolidinium fullerene derivative, C(60)-bis (N, N-dimethylpyrrolidinium iodide), markedly induced apoptosis of JAK2 V617F mutant-induced transformed cells through a novel mechanism, inhibiting c-Jun N-terminal kinase (JNK) activation pathway but not generation of reactive oxygen species (ROS).	Water	21-26	mitogen-activated protein kinase 8	Homo sapiens	230-253
22933020-10	2012	However, STC-1 not only attenuated the drinking responses to ANG II for about 30 min, but also decreased the total water intake over the 1-h period.	Water	115-120	stanniocalcin 1	Rattus norvegicus	9-14
22700868-4	2012	Vasopressin enhanced the rate of lung edema clearance by 30% as compared with untreated control rats (from 0.49 +- 0.02 to 0.64 +- 0.02 ml/h), whereas V(2) receptor antagonists significantly decreased the ability of the lung to clear water (from 0.64 +- 0.02 to 0.31 +- 0.06 ml/h; P &lt; 0.0001).	Water	234-239	arginine vasopressin	Rattus norvegicus	0-11
22750290-3	2012	Here we found that a water-soluble pyrrolidinium fullerene derivative, C(60)-bis (N, N-dimethylpyrrolidinium iodide), markedly induced apoptosis of JAK2 V617F mutant-induced transformed cells through a novel mechanism, inhibiting c-Jun N-terminal kinase (JNK) activation pathway but not generation of reactive oxygen species (ROS).	Water	21-26	mitogen-activated protein kinase 8	Homo sapiens	255-258
22829567-0	2012	Behavior of lysozyme at the electrified water/room temperature ionic liquid interface.	Water	40-45	lysozyme	Homo sapiens	12-20
22829567-1	2012	Between the phases: The globular protein lysozyme was adsorbed and desorbed under electrochemical conditions at the water/room temperature ionic liquid microinterface array; the electrochemical desorption process provides a basis for protein detection at these interfaces.	Water	116-121	lysozyme	Homo sapiens	41-49
22890801-8	2012	MR-based attenuation maps were calculated following Dixon-based fat-water segmentation and an external atlas-based and pattern recognition (AT&amp;PR) algorithm.	Water	68-73	ATPase, class II, type 9B	Mus musculus	0-2
22984091-1	2012	BACKGROUND: Arginine vasopressin, which promotes the reabsorption of renal water is increased in chronic heart failure.	Water	75-80	arginine vasopressin	Rattus norvegicus	21-32
22624831-3	2012	A hydraulic flow rig is used to generate vertical air-water two-phase flows with controllable bubble flow rate.	Water	54-59	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	17-20
22842625-3	2012	Recombinant human Insulin was loaded into the lyophilized polymer matrix, which can be rehydrated by water.	Water	101-106	insulin	Homo sapiens	18-25
23128736-6	2012	Water management affected differently the dissipation performance of substrates: OBX outperformed BXs under water management scenario I, whereas the grape marc compost-biomixture (BX1) was superior at water management scenario II.	Water	0-5	indole-3-glycerol phosphate lyase, chloroplastic	Zea mays	180-183
23143614-6	2012	Human studies suggest that immediate use of ALB during acute resuscitation achieves adequate resuscitation using a lower total overall volume requirement, transiently provides better maintenance of intravascular volume and cardiac output, produces less overall edema gain than crystalloid resuscitation alone but may be associated with increased extravascular lung water accumulation during the first postburn week.	Water	365-370	albumin	Homo sapiens	44-47
23182014-0	2012	Interleukin-6 responses to water immersion therapy after acute exercise heat stress: a pilot investigation.	Water	27-32	interleukin 6	Homo sapiens	0-13
23182014-3	2012	The kinetics of inflammatory markers, such as interleukin-6 (IL-6), during cold-water  immersion have not been characterized.	Water	80-85	interleukin 6	Homo sapiens	46-59
23182014-3	2012	The kinetics of inflammatory markers, such as interleukin-6 (IL-6), during cold-water  immersion have not been characterized.	Water	80-85	interleukin 6	Homo sapiens	61-65
23182014-4	2012	OBJECTIVE: To characterize serum IL-6 responses to water immersion at 2 temperatures and, therefore, to initiate further research into the multidimensional benefits of immersion and the evidence-based selection of specific, optimal immersion  conditions by athletic trainers.	Water	51-56	interleukin 6	Homo sapiens	33-37
23182014-11	2012	CONCLUSIONS: We have provided seed evidence that cold-water immersion is related to subtle IL-6 increases from postexercise values and that warmer water-bath temperatures might dampen this increase.	Water	54-59	interleukin 6	Homo sapiens	91-95
23032559-12	2012	The Nrf2 pathway was induced at a REF of approximately 10 for surface waters and drinking water, and above this enrichment cytotoxicity took over in most samples and quenched the induction.	Water	70-75	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
22915822-1	2012	Herpes simplex virus 1 (HSV-1) was shown to contain catalase, an enzyme able to detoxify hydrogen peroxide by converting it to water and oxygen.	Water	127-132	catalase	Homo sapiens	52-60
22886427-7	2012	rhNRG-1 inhibited mPTP and activated Akt in the presence of H(2)O(2) and further protected the cells from H(2)O(2)-induced apoptosis.	Water	60-65	AKT serine/threonine kinase 1	Homo sapiens	37-40
22992101-4	2012	Absorption of water by the PEDOT:PSS layer followed by corrosion of the grain boundaries of the Ag layer by the corrosive water was thought to be the reason of Ag particle formation and fast performance lowering of the device.	Water	14-19	PSS	Homo sapiens	33-36
22902934-1	2012	Water-soluble and high luminescent l-glutathione-capped-ZnSe quantum dots (QDs) were applied for ultrasensitive Pb(II) detection.	Water	0-5	submaxillary gland androgen regulated protein 3B	Homo sapiens	112-118
22902934-9	2012	This developed method is demonstrated to contain improved sensitive and selective characteristics for the detection of trace Pb(II) in water.	Water	135-140	submaxillary gland androgen regulated protein 3B	Homo sapiens	125-131
22932892-3	2012	Here we show that hepatoma cells and primary hepatocytes strongly up-regulate hepcidin when exposed to low concentrations of H(2)O(2) (0.3-6 muM), concentrations that are comparable with levels of H(2)O(2) released by inflammatory cells.	Water	125-130	latexin	Homo sapiens	141-144
22890080-7	2012	At the end of this period, tap water was added as an option for drinking liquid (voluntary alcohol ingestion) for another 10 days.	Water	31-36	nuclear RNA export factor 1	Rattus norvegicus	27-30
23401969-1	2012	The investigation deals with effect of analogues of conopressin S--a peptide of the vasopressin family with amino acid replacement in the 2nd and 4th positions (characteristic of invertebrate peptides)--on transport of water and ions in the rat kidney.	Water	219-224	arginine vasopressin	Rattus norvegicus	84-95
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
23095290-5	2012	Group-1 served as the control group (n = 12) and received water, whereas groups 2 and 3 were given water suspension of betel nut orally in two dosages, 30 mg and 60 mg, respectively for a period of 5 weeks.	Water	99-104	NUT midline carcinoma, family member 1	Rattus norvegicus	125-128
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22954139-4	2012	Optimal suppressed ion chromatography conditions include the use of 500 muL injection volumes and an AS11 HC analytical column heated to 30  C. The method detection limit of 0.002 muM for phosphite was successfully applied for phosphite determination in natural water samples with recoveries ranging from 90.7 +- 3.2% to 108 +- 1.5%.	Water	262-267	latexin	Homo sapiens	180-183
22828071-5	2012	GDNF was encapsulated in its molecular state by the water-in-oil-in-water (W/O/W) technique or as solid according to the solid-in-oil-in-water (S/O/W) method.	Water	52-57	glial cell derived neurotrophic factor	Homo sapiens	0-4
22828071-5	2012	GDNF was encapsulated in its molecular state by the water-in-oil-in-water (W/O/W) technique or as solid according to the solid-in-oil-in-water (S/O/W) method.	Water	68-73	glial cell derived neurotrophic factor	Homo sapiens	0-4
22828071-5	2012	GDNF was encapsulated in its molecular state by the water-in-oil-in-water (W/O/W) technique or as solid according to the solid-in-oil-in-water (S/O/W) method.	Water	68-73	glial cell derived neurotrophic factor	Homo sapiens	0-4
22480517-2	2012	ET-1 modulates cardiac contractility, systemic and renal vascular resistance, salt and water renal reabsorption, and glomerular function.	Water	87-92	endothelin 1	Homo sapiens	0-4
22910329-1	2012	Human aquaporin-8 (AQP8) channels facilitate the diffusional transport of H(2)O(2) across membranes.	Water	74-79	aquaporin 8	Homo sapiens	6-17
22910329-1	2012	Human aquaporin-8 (AQP8) channels facilitate the diffusional transport of H(2)O(2) across membranes.	Water	74-79	aquaporin 8	Homo sapiens	19-23
22976799-3	2012	METHODS: Mice transplanted with Bcr-Abl-transfected BaF3 cells, received ITF in their drinking water.	Water	95-100	trefoil factor 3, intestinal	Mus musculus	73-76
26593017-6	2012	The PEO in these models is seen to be fully water-solvated at low temperatures but tends to phase separate from water as the temperature is increased, reminiscent of a lower critical solution temperature exhibited by PEO-water mixtures.	Water	44-49	twinkle mtDNA helicase	Homo sapiens	4-7
22982320-3	2012	iPS cells treated with H(2)O(2) showed increases in miR-1 expression, mitochondria dysfunction, cytochrome-c release and apoptosis, Addition of IGF-1 into the iPS cell cultures reduced the H(2)O(2) cytotoxicity.	Water	23-28	insulin like growth factor 1	Homo sapiens	144-149
22982320-3	2012	iPS cells treated with H(2)O(2) showed increases in miR-1 expression, mitochondria dysfunction, cytochrome-c release and apoptosis, Addition of IGF-1 into the iPS cell cultures reduced the H(2)O(2) cytotoxicity.	Water	189-194	insulin like growth factor 1	Homo sapiens	144-149
22998072-0	2012	Characteristic size for onset of coffee-ring effect in evaporating lysozyme-water solution droplets.	Water	76-81	lysozyme	Homo sapiens	67-75
22865888-0	2012	Factors that differentiate the H-bond strengths of water near the Schiff bases in bacteriorhodopsin and Anabaena sensory rhodopsin.	Water	51-56	rhodopsin	Homo sapiens	90-99
22950439-8	2012	So, water molecules may serve as biological catalysts just like the work in the heme enzyme P450 StaP.	Water	4-9	cytoglobin	Homo sapiens	97-101
22950482-5	2012	Specific sites in STX were identified to be important for the electrostatic interactions with the PIP(2) lipids attracted to the protein, and the segregation of PIP(2) lipids near the protein is shown to have a dramatic effect on the positioning of the STX N-terminal segment with respect to the membrane/water interface.	Water	305-310	prolactin induced protein	Homo sapiens	98-101
22950482-5	2012	Specific sites in STX were identified to be important for the electrostatic interactions with the PIP(2) lipids attracted to the protein, and the segregation of PIP(2) lipids near the protein is shown to have a dramatic effect on the positioning of the STX N-terminal segment with respect to the membrane/water interface.	Water	305-310	prolactin induced protein	Homo sapiens	161-164
23045977-3	2012	Thymosin beta4, a 43-amino acid water-soluble peptide with pleiotropic abilities seems to be a promising candidate for the treatment of ischemic heart disease.	Water	32-37	thymosin beta 4 X-linked	Homo sapiens	0-14
22972560-1	2012	A quantitative analysis of the interaction sites of the anti-Alzheimer drug galanthamine with molecular probes (water and benzene molecules) representative of its surroundings in the binding site of acetylcholinesterase (AChE) has been realized through pairwise potentials calculations and quantum chemistry.	Water	112-117	acetylcholinesterase (Cartwright blood group)	Homo sapiens	199-219
22820037-1	2012	The neuropeptide vasopressin has traditionally been associated with vasoconstriction and water reabsorption by the kidneys.	Water	89-94	arginine vasopressin	Homo sapiens	17-28
22872375-2	2012	Significant highest metal concentration in water (0.45 mg L(-1) Cd and 3.94 mg L(-1) Pb) and sediment (2.83 mg kg(-1) Cd and 6.61 mg kg(-1) Pb) were found at the mouth of the Tigre River, where the fishing town of El Moron is located.	Water	43-48	immunoglobulin kappa variable 1-16	Homo sapiens	79-87
23720263-4	2012	The classic RAS can be defined as the ACE-Ang II-AT1R axis that promotes vasoconstriction, water intake, sodium retention, and other mechanisms to maintain blood pressure, as well as increase oxidative stress, fibrosis, cellular growth, and inflammation in pathological conditions.	Water	91-96	angiotensin I converting enzyme	Homo sapiens	38-41
23030646-2	2012	We found that one bolus of H(2)O(2) (10-100 muM) did not affect proliferation, but significantly stimulated migration (143-161% of control) after a 12-hour exposure.	Water	27-32	latexin	Homo sapiens	44-47
22825119-7	2012	Since the bridging hydroxide ion/water in the S conformer is at the position for the nucleophilic attack, the S conformation may simulate the true binding of a substrate to NDM-1.	Water	33-38	NDM-1	Klebsiella pneumoniae	173-178
22727517-10	2012	The antibody used here could recognize Adda group, the conservative part of MCs, which allowed the biosensor to detect both single toxin and the total content of MCs existing in the water sample.	Water	182-187	adducin 1	Homo sapiens	39-43
22683765-8	2012	Collectively, the repeated exposure to water immersion stress decreases Muc2 synthesis in the goblet cells via decreased Cdx2 expression and subsequently reduces the goblet cell number via Notch signaling suppression.	Water	39-44	caudal type homeo box 2	Rattus norvegicus	121-125
22934841-8	2012	RESULTS: In vitro studies revealed that MnSOD mimic MnTm4PyP pretreatment significantly increased viability of neurons after injury by H(2) O(2) .	Water	135-141	superoxide dismutase 2, mitochondrial	Mus musculus	40-45
22243807-3	2012	Reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR analyses revealed significant increases in MT1 and MT2 mRNA expression in the hippocampus, following VPA (4 mg/ml drinking water) treatment for 17 d. Increases in the mRNA and protein expression of the novel neurotrophic factors, conserved dopamine neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor, were detected in the hippocampus and/or striatum.	Water	198-203	metallothionein 1	Rattus norvegicus	118-121
22972560-1	2012	A quantitative analysis of the interaction sites of the anti-Alzheimer drug galanthamine with molecular probes (water and benzene molecules) representative of its surroundings in the binding site of acetylcholinesterase (AChE) has been realized through pairwise potentials calculations and quantum chemistry.	Water	112-117	acetylcholinesterase (Cartwright blood group)	Homo sapiens	221-225
22972560-10	2012	In particular, the positions of several water molecules appearing as strongly conserved in galanthamine-AChE co-crystals are predicted by the calculations.	Water	40-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	104-108
22548241-13	2012	Priming with GM-CSF or TNF-alpha was more effective than IFN-gamma in compensating for the inhibitory PGE(2) effect, since these cytokines induce cells to produce higher H(2)O(2) and TNF-alpha levels.	Water	170-175	tumor necrosis factor	Homo sapiens	23-32
22922289-3	2012	Cyclic STB1 and RSTB1 could induce TiO(2) precipitation in the presence of titanium(IV)-bis-ammonium-lactato-dihydroxide (TiBALDH) precursor in water or tris buffer at pH 8.	Water	144-149	VANGL planar cell polarity protein 2	Homo sapiens	7-11
22487877-6	2012	CONCLUSION: The results obtained indicate that SPI shows excellent potential to favour stabilisation of air/water and oil/water interfaces in food systems.	Water	108-113	chromogranin A	Homo sapiens	47-50
22487877-6	2012	CONCLUSION: The results obtained indicate that SPI shows excellent potential to favour stabilisation of air/water and oil/water interfaces in food systems.	Water	122-127	chromogranin A	Homo sapiens	47-50
22252122-2	2012	AQP1-4 are localized in plasma membranes of renal epithelial cells and are intimately involved in water reabsorption by the kidney.	Water	98-103	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
22252122-4	2012	AQP6 and AQP11 are localized within the cell, with AQP6 involved in anion transport and AQP11 water transport.	Water	94-99	aquaporin 11	Homo sapiens	88-93
22705445-4	2012	In 1992 the Agre group identified CHIP28"s water transport property.	Water	43-48	aquaporin 1 (Colton blood group)	Homo sapiens	34-40
22705445-7	2012	In the natural or model membranes AQP1 is in the form of a homotetramer, however, each monomer has an independent water channel (pore).	Water	114-119	aquaporin 1 (Colton blood group)	Homo sapiens	34-38
22548241-13	2012	Priming with GM-CSF or TNF-alpha was more effective than IFN-gamma in compensating for the inhibitory PGE(2) effect, since these cytokines induce cells to produce higher H(2)O(2) and TNF-alpha levels.	Water	170-175	interferon gamma	Homo sapiens	57-66
22851057-1	2012	Unlike DNA duplexes that release water upon interaction with protein, the binding of DNA G-quadruplex of the thrombin-binding aptamer (TBA) to thrombin takes up water.	Water	33-38	coagulation factor II, thrombin	Homo sapiens	109-117
22705445-8	2012	The three-dimensional structure of AQP1 is described, with a detailed description of the channel (pore), the molecular mechanisms of permeation through the channel of water molecules and exclusion of protons.	Water	167-172	aquaporin 1 (Colton blood group)	Homo sapiens	35-39
22705445-12	2012	The role of AQP1 in red blood cells is discussed based on our comparative studies of water permeability in over 30 species.	Water	85-90	aquaporin 1 (Colton blood group)	Homo sapiens	12-16
23078817-1	2012	This review describes the discovery of rat aquaporin 2 AQP2 as a vasopressin-regulated water channel, and subsequent isolation of human AQP2.	Water	87-92	arginine vasopressin	Rattus norvegicus	65-76
22851057-1	2012	Unlike DNA duplexes that release water upon interaction with protein, the binding of DNA G-quadruplex of the thrombin-binding aptamer (TBA) to thrombin takes up water.	Water	161-166	coagulation factor II, thrombin	Homo sapiens	109-117
22909296-2	2012	In the present study, the structure-activity relationship between the water-soluble manganese (Mn) porphyrin with SOD activity and the in vivo pharmaceutical effect on DCM is reported.	Water	70-75	superoxide dismutase 2, mitochondrial	Mus musculus	114-117
22851057-1	2012	Unlike DNA duplexes that release water upon interaction with protein, the binding of DNA G-quadruplex of the thrombin-binding aptamer (TBA) to thrombin takes up water.	Water	161-166	coagulation factor II, thrombin	Homo sapiens	143-151
22417650-10	2012	Compared with P(aCO2) at the PEEP level of 20 cm H2O, P(aCO2) was significantly lower at 12 cm H2O (P &lt; .001).	Water	95-98	aconitase 2	Homo sapiens	56-60
22954368-0	2012	Aggregation behaviors of PEO-PPO-ph-PPO-PEO and PPO-PEO-ph-PEO-PPO at an air/water interface: experimental study and molecular dynamics simulation.	Water	77-82	protoporphyrinogen oxidase	Homo sapiens	29-32
22770964-5	2012	At a low Al dosage (2.16 mg L-1), a much higher removal of NOM from synthetic water, as evidenced from UV254 and Dissolved Organic Carbon (DOC) measurements, was achieved by the composite coagulants in comparison to that removed by PACl or PACl and chitosan added separately.	Water	78-83	immunoglobulin kappa variable 1-16	Homo sapiens	28-31
23311159-2	2012	METHOD: As for alkaloids, Nucleosil C18 column was adopted with acetonitrile and water containing 0.5% potassium dihydrogen phosphate (6: 94, adjust pH to 3.2 with phosphate acid) as the mobile phase.	Water	81-86	Bardet-Biedl syndrome 9	Homo sapiens	36-39
22935018-3	2012	Notably, this chemistry can be effected by muM-level concentrations of copper(II) ion in water (pH = 6-8) at room temperature to elicit &gt;80-fold enhancement in the green emission at lambda(em) = 530 nm.	Water	89-94	latexin	Homo sapiens	43-46
22659000-1	2012	The interaction of two water soluble branched polyethyleneimine-copper(II) complexes containing bipyridine/phenanthroline with bovine serum albumin (BSA) was studied by, UV-Visible absorption, fluorescence, lifetime measurements and circular dichroism spectroscopic techniques.	Water	23-28	albumin	Homo sapiens	134-147
23289156-2	2012	In order to establish an in vitro estrogen-like compound screening model, the coding region of human ERalpha and ERbeta was separately constructed into pET32-ERalpha and pET43-ERbeta prokaryotic expression vector and water-soluble recombinant ERalpha and ERbeta proteins were expressed in Escherichia coli strain BL21.	Water	217-222	estrogen receptor 1	Homo sapiens	101-108
22835769-0	2012	Iron-complexed adsorptive membrane for As(V) species in water.	Water	56-61	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	39-44
22998280-7	2012	For the water model employed in this work, SPC/E, the electrostatic potential at the water surface is ~-2 V, equivalent to ~80 k(B)T (for T = 300 K), much stronger than previously considered.	Water	8-13	proline rich protein gene cluster	Homo sapiens	43-46
22841723-2	2012	The co-crystal structure reveals a binding configuration which is unique compared to classical catechol PDE4 inhibitors, with boron binding to the activated water in the bimetal center.	Water	157-162	phosphodiesterase 4A	Homo sapiens	104-108
22998280-7	2012	For the water model employed in this work, SPC/E, the electrostatic potential at the water surface is ~-2 V, equivalent to ~80 k(B)T (for T = 300 K), much stronger than previously considered.	Water	85-90	proline rich protein gene cluster	Homo sapiens	43-46
22858581-0	2012	Synthesis of highly fluorescent water-soluble silver nanoparticles for selective detection of Pb(II) at the parts per quadrillion (PPQ) level.	Water	32-37	submaxillary gland androgen regulated protein 3B	Homo sapiens	94-100
22858581-1	2012	This communication reports for the first time the synthesis of water-soluble glutathione protected highly fluorescence (Phi = 0.18) silver nanoparticles for the selective and highly sensitive sensing of Pb(ii) at the parts per quadrillion (PPQ) level.	Water	63-68	submaxillary gland androgen regulated protein 3B	Homo sapiens	203-209
22934980-1	2012	We propose a novel electrochemical detection system for alkaline phosphatase (ALP) activity using the difference in water and oil solubilities between the substrate, ferrocene ethyl phosphate ester (FcEtOPO(3)(2-)), and the enzymatic product, ferroceneethanol (FcEtOH).	Water	116-121	alkaline phosphatase, placental	Homo sapiens	56-76
22934980-1	2012	We propose a novel electrochemical detection system for alkaline phosphatase (ALP) activity using the difference in water and oil solubilities between the substrate, ferrocene ethyl phosphate ester (FcEtOPO(3)(2-)), and the enzymatic product, ferroceneethanol (FcEtOH).	Water	116-121	alkaline phosphatase, placental	Homo sapiens	78-81
22934980-2	2012	In this system, water droplets containing ALP and FcEtOPO(3)(2-) were placed on a Pt disk microelectrode and surrounded by a mineral oil.	Water	16-21	alkaline phosphatase, placental	Homo sapiens	42-45
22963223-3	2012	Computed potential energy profiles (PEPs) reveal a lower yl oxo exchange transition state for uranyl(V)/water as compared with neptunyl(V)/water and plutonyl(V)/water.	Water	104-109	leucine aminopeptidase 3	Homo sapiens	36-40
22988890-11	2012	Among the diverse extracts of P. linteus, water soluble extract of P. linteus (WA) significantly reduced the IgE production in primary B cells and B cell line U266B1.	Water	42-47	immunoglobulin heavy constant epsilon	Homo sapiens	109-112
22988890-14	2012	CONCLUSIONS: Our study indicates that protective effect of water soluble extract of P. linteus in atopic dermatitis is mediated by inhibiting IgE production and expression of AD associated pathogenic cytokines as well as chemokines, suggesting the beneficial effect of P. linteus to modulate allergic skin disease.	Water	59-64	immunoglobulin heavy constant epsilon	Homo sapiens	142-145
22884577-1	2012	An alpha-cyclodextrin-[60]fullerene conjugate with a flexible linker at the secondary face of alpha-cyclodextrin has been prepared, which displays significant water solubility and, more importantly, acts as a new class of HCV entry inhibitor with IC(50) at 0.17 muM level.	Water	159-164	latexin	Homo sapiens	262-265
23079979-1	2012	The insulin growth factor 1/phosphatase and tensin homologue deleted on chromosome 10/Akt/forkhead box (IGF-1/PTEN/Akt/FoxO) signaling pathway reportedly exhibits gastroprotective effects by reducing water immersion and restraint stress (WRS)-induced gastric mucosal cell apoptosis.	Water	200-205	AKT serine/threonine kinase 1	Rattus norvegicus	86-89
23079979-1	2012	The insulin growth factor 1/phosphatase and tensin homologue deleted on chromosome 10/Akt/forkhead box (IGF-1/PTEN/Akt/FoxO) signaling pathway reportedly exhibits gastroprotective effects by reducing water immersion and restraint stress (WRS)-induced gastric mucosal cell apoptosis.	Water	200-205	AKT serine/threonine kinase 1	Rattus norvegicus	115-118
22365890-1	2012	The enzyme catalase catalyzes the breakdown of hydrogen peroxide into oxygen and water.	Water	81-86	catalase	Homo sapiens	11-19
22824864-4	2012	PQQ inhibited protein tyrosine phosphatase 1B (PTP1B), which negatively regulates the EGFR signaling by tyrosine dephosphorylation, to oxidatively modify the catalytic cysteine through its redox cycling activity to generate H(2)O(2).	Water	224-229	epidermal growth factor receptor	Homo sapiens	86-90
22809669-1	2012	The neurohypophysial peptides of the vasopressin (VP) and oxytocin (OT) families regulate salt and water homeostasis and reproduction through distinct G protein-coupled receptors.	Water	99-104	arginine vasopressin	Homo sapiens	37-48
22967596-9	2012	This water soluble fluorescent nanocomposite showed a set of favorable properties to be used as a sensor for the C-reactive protein in serum samples, at concentrations of risk levels.	Water	5-10	C-reactive protein	Homo sapiens	113-131
22967530-6	2012	The method was validated by determining Pb(II) and Cd(II) in certified reference waste water (SPS-WW1).	Water	87-92	submaxillary gland androgen regulated protein 3B	Homo sapiens	40-46
22967530-7	2012	Finally, the method was applied to the determination of Pb(II) and Cd(II) in commercial mineral water samples after UV digestion.	Water	96-101	submaxillary gland androgen regulated protein 3B	Homo sapiens	56-62
22982873-6	2012	The development of orally active direct thrombin inhibitors was challenging because of the need to convert water-soluble, poorly absorbable, active site inhibitors into fat-soluble prodrugs that were then transformed back to the active drug after intestinal absorption.	Water	107-112	coagulation factor II, thrombin	Homo sapiens	40-48
22861526-10	2012	Finally, analysis of ATR/FTIR spectra revealed that, with increasing water content, the average hydrogen-bond enthalpy of the fructose hydroxyls decreases by ~2.5 kJ/mol.	Water	69-74	ATR serine/threonine kinase	Homo sapiens	21-24
22887038-1	2012	Crystal clear: An end-on (EO) azide-bridged Co(II)  layer (see scheme; 1) with coordinated water molecules, long spacer p-XBP4 ligands, and unbound azide anions was evacuated to generate a dehydrated sample of 2.	Water	91-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22894179-7	2012	Furthermore, at low contents (h = 0.075), water systematically stiffens the vibrational motions of lysozyme and trehalose, whereas it increases their MSDs on the nanosecond (ns) time scale.	Water	42-47	lysozyme	Homo sapiens	99-107
22894179-8	2012	This stems from the hydrogen bonds (HBs) that lysozyme and trehalose form with water, which, interestingly, are stronger than the ones they form with each other but which, nonetheless, relax faster on the ns time scale, given the larger mobility of water.	Water	79-84	lysozyme	Homo sapiens	46-54
22894179-8	2012	This stems from the hydrogen bonds (HBs) that lysozyme and trehalose form with water, which, interestingly, are stronger than the ones they form with each other but which, nonetheless, relax faster on the ns time scale, given the larger mobility of water.	Water	249-254	lysozyme	Homo sapiens	46-54
22894179-9	2012	Moreover, lysozyme interacts preferentially with water in the hydrated LT mixtures, and trehalose appears to slow down significantly the relaxation of lysozyme-water HBs.	Water	49-54	lysozyme	Homo sapiens	10-18
22894179-9	2012	Moreover, lysozyme interacts preferentially with water in the hydrated LT mixtures, and trehalose appears to slow down significantly the relaxation of lysozyme-water HBs.	Water	160-165	lysozyme	Homo sapiens	151-159
22927377-5	2012	Through an application of the methods to cytochrome c and ubiquitin, we identify sites of water binding and measure the millisecond dynamics of bound waters in protein crevices.	Water	90-95	cytochrome c, somatic	Homo sapiens	41-53
26605746-1	2012	By introducing an external field to temper short-range protein water interactions, we regularize the statistical problem of calculating the hydration free energy, mu(ex), of the protein cytochrome C using the potential distribution theorem.	Water	63-68	cytochrome c, somatic	Homo sapiens	186-198
22857150-1	2012	Binding properties of cesium and thallium cations by an enantiopure cryptophane derivative PP-1 have been investigated in water under basic conditions.	Water	122-127	inorganic pyrophosphatase 1	Homo sapiens	91-95
22892127-3	2012	Our Western-Blot results in primary cultured human skin keratinocytes and in HaCaT cell line demonstrated that UVB radiation and hydrogen peroxide (H(2)O(2)) induced Cyp-D expression, which was inhibited by anti-oxidant N-acetyl cysteine (NAC).	Water	148-154	peptidylprolyl isomerase F	Homo sapiens	166-171
22729505-12	2012	CONCLUSION: Shorter T1(rho) and T2 values after running suggest alteration in the water content and collagen fiber orientation of the articular cartilage.	Water	82-87	rhodopsin	Homo sapiens	20-27
22913479-1	2012	A novel, highly efficient, and stable water oxidation catalyst was prepared by a pH-controlled adsorption of Co(II) on ~10 nm diameter silica nanoparticles.	Water	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
22718889-0	2012	Water restriction increases renal inner medullary manganese superoxide dismutase (MnSOD).	Water	0-5	superoxide dismutase 2, mitochondrial	Mus musculus	82-87
22718889-6	2012	Water restriction, which elevates renal medullary NaCl and urea, increases MnSOD protein, accompanied by a proportionate increase in MnSOD enzymatic activity in the inner medulla, but not in the cortex or the outer medulla.	Water	0-5	superoxide dismutase 2, mitochondrial	Mus musculus	75-80
22718889-6	2012	Water restriction, which elevates renal medullary NaCl and urea, increases MnSOD protein, accompanied by a proportionate increase in MnSOD enzymatic activity in the inner medulla, but not in the cortex or the outer medulla.	Water	0-5	superoxide dismutase 2, mitochondrial	Mus musculus	133-138
22842525-1	2012	Aquaglyceroporin-9 (AQP9) facilitates diffusion of water and energy substrates such as glycerol and monocarboxylates.	Water	51-56	aquaporin 9	Homo sapiens	0-18
22842525-1	2012	Aquaglyceroporin-9 (AQP9) facilitates diffusion of water and energy substrates such as glycerol and monocarboxylates.	Water	51-56	aquaporin 9	Homo sapiens	20-24
22739536-9	2012	These results demonstrate that AT(1a) receptor-mediated ANG II signaling is required to maintain tonic AVP release and regulate V(2) receptor-mediated responses to water deprivation in the inner medulla.	Water	164-169	angiotensin II receptor, type 1a	Mus musculus	31-36
22739536-9	2012	These results demonstrate that AT(1a) receptor-mediated ANG II signaling is required to maintain tonic AVP release and regulate V(2) receptor-mediated responses to water deprivation in the inner medulla.	Water	164-169	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	56-62
22739536-1	2012	It is well recognized that ANG II interacts with arginine vasopressin (AVP) to regulate water reabsorption and urine concentration in the kidney.	Water	88-93	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	27-33
22038315-0	2012	Acute effects of a single warm-water bath on serum adiponectin and leptin levels in healthy men: a pilot study.	Water	31-36	adiponectin, C1Q and collagen domain containing	Homo sapiens	51-62
23240185-2	2012	Arsenate, As(V) oxoanion, removal is crucial due to arsenate"s serious effects on health and its existence in water worldwide.	Water	110-115	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	10-15
22668974-11	2012	These results showed that berberine was able to increase the expression of NHE3 and AQP4, suggesting that berberine might exhibit its anti-diarrhoeal effect partially by enhancing the absorption of Na(+) and water.	Water	208-213	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	75-79
23243859-4	2012	The diffusion fluxes of lakes were mainly based on NH4(+) -N diffusion in the west Jiangsu, and ions of most of lakes diffused from overlying water to sediment, NO3(-) -N diffused from sediment to overlying water in lakes except for Lake Hongze, Lake Shijiu and Lake Xuanwu.	Water	207-212	NBL1, DAN family BMP antagonist	Homo sapiens	161-164
23243862-0	2012	[Relationship between dissolved organic carbon and DBP in the Pearl River water].	Water	74-79	D-box binding PAR bZIP transcription factor	Homo sapiens	51-54
22922672-1	2012	Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene, which regulates chloride and water transport across all epithelia and affects multiple organs, including the lungs.	Water	169-174	CF transmembrane conductance regulator	Homo sapiens	75-79
22833363-8	2012	The stability results showed that the complex was stable for 1 year at -20  C. The interaction mechanism of this formation is that the peptide bonds of insulin interact with the water-soluble head of phospholipids, forming a reverse micelle-like structure.	Water	178-183	insulin	Homo sapiens	152-159
22735908-0	2012	Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development             and healing of water immersion and restraint stress-induced gastric ulcers in             rats.	Water	98-103	AKT serine/threonine kinase 1	Rattus norvegicus	25-28
22735908-1	2012	Insulin-like growth factor 1 (IGF-1) and Akt [also known as protein kinase B (PKB)] proteins have been reported to exhibit gastroprotective effects by reducing water immersion and restraint stress (WRS)-induced gastric mucosal cellular apoptosis.	Water	160-165	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
22797762-4	2012	This study shows that KatG is the major housekeeping catalase of DC3000 and provides protection against menadione-generated endogenous H(2)O(2).	Water	135-140	catalase/peroxidase HPI	Pseudomonas syringae pv. tomato str. DC3000	22-26
22922672-1	2012	Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene, which regulates chloride and water transport across all epithelia and affects multiple organs, including the lungs.	Water	169-174	CF transmembrane conductance regulator	Homo sapiens	81-132
22776833-3	2012	AIM OF STUDY: In this study, we examined the effects of a water-soluble beta-d-fructan (MDG-1) from O. japonicus on type 2 diabetes through the PI3K/Akt pathway in a diabetic KKAy mouse model.	Water	58-63	thymoma viral proto-oncogene 1	Mus musculus	149-152
22554013-3	2012	METHODS: We investigated the expression pattern and localization of aquaporin-1, an important channel protein involved in plasma membrane water permeability, in patients with anterior disc displacement (both with and without reduction), with a view to assessing the characteristics of local tissue responses to the microenvironmental changes induced by abnormal mechanical loading of the displaced disc.	Water	138-143	aquaporin 1 (Colton blood group)	Homo sapiens	68-79
22687522-11	2012	The unchanged and selective adsorption in realistic water observed for MIP-cryo was concluded to be due to a successful imprinting, here controlled using a non-imprinted polymer (NIP).	Water	52-57	major intrinsic protein of lens fiber	Homo sapiens	71-74
22542687-3	2012	Vibrational spectra (ATR and Raman) clearly indicated hydrogen bonding of the studied hydrazones through the carbonyl, amino and hydroxyl groups with water molecules.	Water	150-155	ATR serine/threonine kinase	Homo sapiens	21-24
25874708-1	2012	UNLABELLED:  The aim of this study was to investigate the influence of tap water on microbial colonization of skin wounds in rats.	Water	75-80	nuclear RNA export factor 1	Rattus norvegicus	71-74
22732728-12	2012	The methanolic and water extracts of the same plant exhibited high inhibitory effects towards AChE with IC(50) values of 0.22 and 0.26mg/ml, respectively.	Water	19-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-98
22419270-7	2012	The suppressive effect of "Sunrouge" water extract on AChE activity in human neuroblastoma SK-N-SH cells was the strongest among the three tea cultivars ("Sunrouge", "Yabukita" and "Benifuuki").	Water	37-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	54-58
22834785-1	2012	The human insulin (HI) protein was examined to elucidate its structure at the air-water interface.	Water	82-87	insulin	Homo sapiens	10-17
22829409-0	2012	DFT calculations suggest a new type of self-protection and self-inhibition mechanism in the mammalian heme enzyme myeloperoxidase: nucleophilic addition of a functional water rather than one-electron reduction.	Water	169-174	myeloperoxidase	Homo sapiens	114-129
22882159-1	2012	In this work, we present a series of fully atomistic molecular dynamics (MD) simulations to study lysozyme"s orientation-dependent adsorption on polyethylene (PE) surface in explicit water.	Water	183-188	lysozyme	Homo sapiens	98-106
22856639-5	2012	Incorporating explicit water molecules in the simulations results in higher affinity for fibronectin adsorption to more hydrophobic surface of CO-HDI surfaces, emphasizing the role that water molecules play during adsorption.	Water	23-28	fibronectin 1	Homo sapiens	89-100
22947940-5	2012	Applications to T4 lysozyme, the Trp-cage, the aquaporin channels Aqy1 and hAQP1, and the CLC-ec1 chloride antiporter are presented in which the active site geometry, the hydrophobic solvent-accessible surface, channel gating dynamics, water permeability (p(f)), and a dihedral angle are defined as functional order parameters.	Water	236-241	aquaporin 1 (Colton blood group)	Homo sapiens	75-80
22856639-5	2012	Incorporating explicit water molecules in the simulations results in higher affinity for fibronectin adsorption to more hydrophobic surface of CO-HDI surfaces, emphasizing the role that water molecules play during adsorption.	Water	186-191	fibronectin 1	Homo sapiens	89-100
22820194-2	2012	The aquaporin (AQP) water channels, in particular AQP1 and -4, have been suggested to play an important role in fluid homeostasis of the myocardium.	Water	20-25	aquaporin 1 (Colton blood group)	Homo sapiens	50-61
22920127-0	2012	Nonequilibrium molecular dynamics simulations of the thermal conductivity of water: a systematic investigation of the SPC/E and TIP4P/2005 models.	Water	77-82	proline rich protein gene cluster	Homo sapiens	118-121
22920127-1	2012	We report an extensive nonequilibrium molecular dynamics investigation of the thermal conductivity of water using two of the most accurate rigid nonpolarizable empirical models available, SPC/E and TIP4P/2005.	Water	102-107	proline rich protein gene cluster	Homo sapiens	188-191
22626830-6	2012	Analytical results of Hg(2+) spiked into tap water and lake water by the sensor were in good agreement with mass spectrometry data.	Water	45-50	SEC14 like lipid binding 2	Homo sapiens	41-44
22124766-4	2012	Novel water-in-water emulsion technique was used to prepare insulin-loaded nanoparticles.	Water	6-11	insulin	Homo sapiens	60-67
22124766-4	2012	Novel water-in-water emulsion technique was used to prepare insulin-loaded nanoparticles.	Water	15-20	insulin	Homo sapiens	60-67
22773836-7	2012	Studies using the H(2)O(2) biosensor HyPer2 reveal that angiotensin-II promotes increases in intracellular H(2)O(2).	Water	18-23	angiotensinogen	Homo sapiens	56-70
22746274-2	2012	We previously discovered 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide as a novel, small-molecule HIF-1 pathway inhibitor in a high-throughput cell-based assay, but its in vivo delivery is hampered by poor aqueous solubility (0.009 muM in water; log P(7.4) = 3.7).	Water	275-280	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-139
22748767-2	2012	We report the crystal structure of a TIP49b hexamer and the comparative analysis of large-scale conformational flexibility of TIP49a, TIP49b, and TIP49a/TIP49b complexes using molecular modeling and molecular dynamics simulations in a water environment.	Water	235-240	RuvB like AAA ATPase 2	Homo sapiens	37-43
22748767-2	2012	We report the crystal structure of a TIP49b hexamer and the comparative analysis of large-scale conformational flexibility of TIP49a, TIP49b, and TIP49a/TIP49b complexes using molecular modeling and molecular dynamics simulations in a water environment.	Water	235-240	RuvB like AAA ATPase 1	Homo sapiens	126-132
22748767-2	2012	We report the crystal structure of a TIP49b hexamer and the comparative analysis of large-scale conformational flexibility of TIP49a, TIP49b, and TIP49a/TIP49b complexes using molecular modeling and molecular dynamics simulations in a water environment.	Water	235-240	RuvB like AAA ATPase 1	Homo sapiens	146-152
22709954-9	2012	In conclusion, our results demonstrate that a novel oil/water emulsion, SPO1, is a potent Th1 adjuvant for use in influenza and other vaccines, as it induces strong mucosal and systemic immune responses.	Water	56-61	negative elongation factor complex member C/D, Th1l	Mus musculus	90-93
22796758-5	2012	Taking advantages of the high adsorption capacity, fast adsorption rate and quick magnetic separation from treated water, the gamma-Fe(2)O(3) CHNs developed in the present study is expected to be an efficient magnetic adsorbent for As(V) removal from aqueous solutions.	Water	115-120	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	232-237
22879717-8	2012	In addition, spa spring water attenuated the differentiation process of subsets of CD4(+) T cells, i.e., Th1, Th2 and Th17 cells.	Water	24-29	CD4 molecule	Homo sapiens	83-86
22879717-10	2012	CONCLUSION: Spa spring water treatment suppressed the inflammatory cytokines production and also modulated the differentiation of CD4(+) T cells into Th1, Th2, and Th17 cells, but not the T(regs) cells.	Water	23-28	CD4 molecule	Homo sapiens	130-133
22581383-9	2012	Interestingly, 24 h of water deprivation increased modification of VACM-1 by an ubiquitin-like protein, Nedd8, essential for cullin-dependent E3 ligase activity.	Water	23-28	NEDD8 ubiquitin like modifier	Rattus norvegicus	104-109
22617945-4	2012	The increase in PCB concentrations on second sampling is attributed to the increase in contaminated sediments in the river sites and to the overflow of contaminated water in the lake sites; both of which could have been caused by the flooding event that occurred in September 2009.	Water	165-170	pyruvate carboxylase	Homo sapiens	16-19
22596086-0	2012	Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway.	Water	22-27	AKT serine/threonine kinase 1	Homo sapiens	132-135
22766127-2	2012	In the crystal structure, H(3)L adopting a transoid conformation occurs as a neutral molecule linked with a water molecule by an intermolecular hydrogen bond.	Water	108-113	H3 clustered histone 2	Homo sapiens	26-31
22576132-0	2012	HSP32 (HO-1) inhibitor, copoly(styrene-maleic acid)-zinc protoporphyrin IX, a water-soluble micelle as anticancer agent: In vitro and in vivo anticancer effect.	Water	78-83	heme oxygenase 1	Mus musculus	0-5
22576132-0	2012	HSP32 (HO-1) inhibitor, copoly(styrene-maleic acid)-zinc protoporphyrin IX, a water-soluble micelle as anticancer agent: In vitro and in vivo anticancer effect.	Water	78-83	heme oxygenase 1	Mus musculus	7-11
22596086-9	2012	In conclusion, water extract of HA, but not of HP, controlled CRC proliferation and specifically acted on mutant and not wild-type BRAF.	Water	15-20	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	131-135
22854768-7	2012	Sixteen subjects with significantly lower PLM indices at baseline required optimal CPAP levels higher than the sample average of 8.2 cm H2O (P = 0.032).	Water	136-139	FXYD domain containing ion transport regulator 1	Homo sapiens	42-45
23156782-5	2012	The water fog is seemed as absorbing, emitting and anisotropic scattering medium, and the medium radiation, multiple scattering, target radiation flux, and environment influence such as the conductivity, convection turbulent heat diffusion and evaporation is calculated.	Water	4-9	zinc finger protein, FOG family member 1	Homo sapiens	10-13
21586600-7	2012	Our results highlighted that incorporation of Vit.E into P(D,L)LA sponges modified the sponge morphology, decreased P(D,L)LA water uptake and degradation, and modified protein releasing kinetics.	Water	125-130	vitrin	Homo sapiens	46-49
32480809-12	2012	Sequence divergence at a primary structure level in other regions of the gene was evident amongst the isoforms, which likely contributes to variation in gene regulation and expression in response to water deficit within this subfamily of IVR1 isoforms in wheat.	Water	199-204	ATP synthase subunit alpha, chloroplastic	Triticum aestivum	238-242
23213874-1	2012	The spatial variation in nitrate-nitrogen (NO3- -N) concentrations in surface water of ten sampling sites in the Beijing urban ecosystem from Kunminghu Lake to Tonghui River were assessed using monitoring data from 2009 to 2010.	Water	78-83	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
23213875-2	2012	Contents of 28 PCB congeners in surface water samples were measured using Varian CP3800/300 GC-MS/MS technique.	Water	40-45	pyruvate carboxylase	Homo sapiens	15-18
22805778-2	2012	The water channel proteins astrocytic aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are known to be abnormally expressed in AD brains, but the expression of AQPs surrounding SPs and cerebral amyloid angiopathy has not been described in detail.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	38-49
22750253-4	2012	We demonstrate the use of this restraint using a dataset from the water to protein magnetization transfer experiment on the protein Bax and the solvent paramagnetic relaxation enhancement experiment on the protein ubiquitin and Qua1 homodimer.	Water	66-71	BCL2 associated X, apoptosis regulator	Homo sapiens	132-135
22805778-2	2012	The water channel proteins astrocytic aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are known to be abnormally expressed in AD brains, but the expression of AQPs surrounding SPs and cerebral amyloid angiopathy has not been described in detail.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	51-55
22348807-1	2012	BACKGROUND AND OBJECTIVES: The Colton blood group antigens are carried by the AQP1 water channel.	Water	83-88	aquaporin 1 (Colton blood group)	Homo sapiens	78-82
22702899-0	2012	Water-refined solution structure of the human Grb7-SH2 domain in complex with the erbB2 receptor peptide pY1139.	Water	0-5	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-87
22702899-1	2012	We report a refinement in implicit water of the previously published solution structure of the Grb7-SH2 domain bound to the erbB2 receptor peptide pY1139.	Water	35-40	erb-b2 receptor tyrosine kinase 2	Homo sapiens	124-129
22659458-3	2012	Daily stem radius change (SRC(d)) was primarily influenced by the atmospheric demand for water vapor (expressed either as vapor pressure deficit (D) or relative air humidity (RH)) while rainfall, soil matrix potential, temperature and radiation were only secondary factors.	Water	89-94	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	26-29
22659458-5	2012	The positive effect of a low atmospheric water vapor demand on SRC(d) was largest in June during the period of maximal radial growth rate and persisted when observation windows of 7 or 21 days instead of 1 day were used.	Water	41-46	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	63-66
22913779-10	2012	The high cyclic adenosine monophosphate (cAMP) concentrations activate the cystic fibrosis transmembrane conductance regulator, causing a dramatic efflux of ions and water from infected enterocytes and leading to watery diarrhea.	Water	166-171	CF transmembrane conductance regulator	Homo sapiens	75-126
22680618-1	2012	A new composite material based on deposition of nanosized zerovalent iron (nZVI) particles and cyanocobalamine (vitamin B12) on a diatomite matrix is presented, for catalytic transformation of organic contaminants in water.	Water	217-222	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	120-123
22352456-6	2012	Two types of water models (SPC/E and TIP3P) are used for solvation.	Water	13-18	proline rich protein gene cluster	Homo sapiens	27-30
22709431-1	2012	The water-soluble hydrophilic part of human Abeta peptide has been extended to include a C-terminal cysteine residue.	Water	4-9	amyloid beta precursor protein	Homo sapiens	44-49
22352456-7	2012	When solvated by SPC/E water, whose HOH angle follows an ideal tetrahedron, the structural characteristics of triad is compact in the bulk systems.	Water	23-28	proline rich protein gene cluster	Homo sapiens	17-20
22726924-2	2012	WaterLOGSY (Water-Ligand Observed via Gradient SpectroscopY) NMR was used to detect fragments binding to thrombin and these fragments were followed up by Biacore A100 affinity measurements and enzyme assays.	Water	0-5	coagulation factor II, thrombin	Homo sapiens	105-113
22739063-4	2012	In the case of water, the relationship between water-like anomalies and solvation is studied by examining the hydration of spherical solutes (Na(+), Cl(-), Ar) in water models with different temperature regimes of anomalies (SPC/E, TIP4P and mTIP3P).	Water	15-20	proline rich protein gene cluster	Homo sapiens	225-228
22822398-3	2012	CFTR is a cyclic AMP-dependent chloride channel that is localized to the apical membrane in epithelial cells where it plays a key role in salt and water homeostasis.	Water	147-152	CF transmembrane conductance regulator	Homo sapiens	0-4
23189723-7	2012	Compared with the normal group, within 7 days after the administration, water extracted components in 0.63-5.0 g x kg(-1) dose scope could cause significant damage to liver, the activity of ALT, AST, AKP, TBI elevated, while ALB reduced, and liver ratio increased, and under light microscope, the different doses" liver tissue of mice all had different degree"s edema, fatty degeneration in liver cells and interstitial congestion.	Water	72-77	transmembrane protease, serine 11d	Mus musculus	195-198
22246045-6	2012	By mixing water with methanol, a refolding of cytochrome C is observed as the water percentage increases in the plume due to the preponderant evaporation of volatile methanol.	Water	10-15	cytochrome c, somatic	Homo sapiens	46-58
22575779-10	2012	Experimental results were discussed and explained on the basis of two- and three-dimensional copolymer structure taking into account that PPO chains could be partially immersed in hexane and water.	Water	191-196	protoporphyrinogen oxidase	Homo sapiens	138-141
22246045-6	2012	By mixing water with methanol, a refolding of cytochrome C is observed as the water percentage increases in the plume due to the preponderant evaporation of volatile methanol.	Water	78-83	cytochrome c, somatic	Homo sapiens	46-58
22676472-1	2012	Efficient incorporation of (PtCl3EtOH)(-) anion derived from CisPt moiety into ureasil-PPO (poly(propylene oxide)) network was achieved from one-pot sol-gel synthesis carried out in the presence of water, HCl, and ethanol.	Water	198-203	protoporphyrinogen oxidase	Homo sapiens	87-90
22612268-0	2012	Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect.	Water	33-38	coagulation factor II, thrombin	Homo sapiens	50-58
22612268-1	2012	Well-ordered water molecules are displaced from thrombin"s hydrophobic S3/4-pocket by P3-varied ligands (Gly, d-Ala, d-Val, d-Leu to d-Cha with increased hydrophobicity and steric requirement).	Water	13-18	coagulation factor II, thrombin	Homo sapiens	48-56
22676472-7	2012	In situ Raman monitoring of Pt species decomplexation induced by immersion of hybrid matrix in water highlighted the specific participation of Pt ligands in interaction with the urea group and of NH4(+) cations coordinated by ether-type oxygen atoms in the formation of supramolecular interactions between the PPO chains.	Water	95-100	protoporphyrinogen oxidase	Homo sapiens	310-313
22676472-8	2012	The electrospray mass spectrometry analysis of the Pt species released in water from the ureasil-PPO hybrid evidenced that the structure of the complex, NH4 (PtCl3 EtOH), incorporated in the matrix is totally preserved after delivery.	Water	74-79	protoporphyrinogen oxidase	Homo sapiens	97-100
22676325-4	2012	As(III) and As(V) sorption was best described by the Freundlich and Langmuir isotherm, respectively, with a maximum As(V) uptake capacity of ~200 mumol g(-1) in synthetic water.	Water	171-176	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	12-17
22676325-4	2012	As(III) and As(V) sorption was best described by the Freundlich and Langmuir isotherm, respectively, with a maximum As(V) uptake capacity of ~200 mumol g(-1) in synthetic water.	Water	171-176	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	116-121
22684029-7	2012	RESULTS: HIF-1 transcriptional activity in HeLa cells was enhanced by low doses (0.05-0.5 mmol/L) of H(2)O(2), but suppressed by high doses (0.75-8.0 mmol/L) of H(2)O(2).	Water	101-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-14
22716094-3	2012	The detection limits of A and E toward CN(-) in water are 100 and 5 muM, respectively.	Water	48-53	latexin	Homo sapiens	68-71
22684029-7	2012	RESULTS: HIF-1 transcriptional activity in HeLa cells was enhanced by low doses (0.05-0.5 mmol/L) of H(2)O(2), but suppressed by high doses (0.75-8.0 mmol/L) of H(2)O(2).	Water	161-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-14
22610603-5	2012	By adding water (1.00 +- 0.01) g into the vial containing the CRM, the C-peptide solution in 10 mM phosphate buffer saline (pH 6.6) is reconstituted.	Water	10-15	insulin	Homo sapiens	71-80
22492943-3	2012	Since ANG II activates PKC in many cell types, we tested the hypothesis that ANG II-induced regulation of water and urea transport is mediated by PKC.	Water	106-111	protein kinase C, alpha	Mus musculus	146-149
22484042-0	2012	Water-soluble Ag(2)S quantum dots for near-infrared fluorescence imaging in vivo.	Water	0-5	angiotensin II receptor, type 1a	Mus musculus	14-20
22484042-1	2012	A one-step method for synthesizing water-soluble Ag(2)S quantum dots terminated with carboxylic acid group has been reported.	Water	35-40	angiotensin II receptor, type 1a	Mus musculus	49-55
22275058-7	2012	IL-7 encapsulated PLGA microparticles were first synthesized using a water/organic/water double emulsion method, release from the particles was then optimized using in vitro release studies and therapeutic effectiveness was finally studied in animal studies.	Water	69-74	interleukin 7	Mus musculus	0-4
22275058-7	2012	IL-7 encapsulated PLGA microparticles were first synthesized using a water/organic/water double emulsion method, release from the particles was then optimized using in vitro release studies and therapeutic effectiveness was finally studied in animal studies.	Water	83-88	interleukin 7	Mus musculus	0-4
22431190-3	2012	Our work is to investigate if IL-6 preconditioning has protective effects on neonatal rat ventricular cardiomyocytes in response to H(2)O(2) and its underlying mechanism.	Water	132-137	interleukin 6	Rattus norvegicus	30-34
22445956-0	2012	Chronic exposure to contaminated drinking water stimulates PPAR expression in mice livers.	Water	42-47	peroxisome proliferator activated receptor alpha	Mus musculus	59-63
22503636-10	2012	Peak concentrations of trace elements were frequently observed during the onset of cloud/fog events when liquid water contents of cloud/fog water were usually low and large amount of pollutants were accumulated in the ambient air.	Water	112-117	zinc finger protein, FOG family member 1	Homo sapiens	89-92
22503636-10	2012	Peak concentrations of trace elements were frequently observed during the onset of cloud/fog events when liquid water contents of cloud/fog water were usually low and large amount of pollutants were accumulated in the ambient air.	Water	112-117	zinc finger protein, FOG family member 1	Homo sapiens	136-139
22503636-15	2012	The composition of cloud/fog water influenced by an Asian dust storm event was reported, which was seldom found in the literature.	Water	29-34	zinc finger protein, FOG family member 1	Homo sapiens	25-28
22445956-7	2012	The SW and DW posed no obvious hepatotoxicity on mice and PPAR-alpha/-gamma could be used as a novel biomarker to assess public health risk induced by slightly contaminated drinking water.	Water	182-187	peroxisome proliferator activated receptor alpha	Mus musculus	58-68
22578809-10	2012	CONCLUSIONS: This was the first study showing an excess risk of different congenital anomalies related to chlorite and chlorate exposure via drinking water: further research is needed to confirm the observed relationships in large datasets, specifically for chlorate, an unregulated DBP.	Water	150-155	D-box binding PAR bZIP transcription factor	Homo sapiens	283-286
22526928-4	2012	M1 water treatment increased the mRNA and protein levels of glucose regulation protein 78 (GRP78) and C/EBP homologous protein (CHOP), and decreased the mRNA levels of B-cell lymphoma 2 (Bcl-2).	Water	3-8	heat shock protein 5	Mus musculus	60-89
22526928-4	2012	M1 water treatment increased the mRNA and protein levels of glucose regulation protein 78 (GRP78) and C/EBP homologous protein (CHOP), and decreased the mRNA levels of B-cell lymphoma 2 (Bcl-2).	Water	3-8	heat shock protein 5	Mus musculus	91-96
22526928-4	2012	M1 water treatment increased the mRNA and protein levels of glucose regulation protein 78 (GRP78) and C/EBP homologous protein (CHOP), and decreased the mRNA levels of B-cell lymphoma 2 (Bcl-2).	Water	3-8	B cell leukemia/lymphoma 2	Mus musculus	168-185
22526928-4	2012	M1 water treatment increased the mRNA and protein levels of glucose regulation protein 78 (GRP78) and C/EBP homologous protein (CHOP), and decreased the mRNA levels of B-cell lymphoma 2 (Bcl-2).	Water	3-8	B cell leukemia/lymphoma 2	Mus musculus	187-192
22526928-5	2012	M2 water treatment up-regulated GRP78 mRNA and protein expression, whereas H water treatment up-regulated mRNA and protein expression of GRP78 and caspase-12.	Water	3-8	heat shock protein 5	Mus musculus	32-37
22526928-5	2012	M2 water treatment up-regulated GRP78 mRNA and protein expression, whereas H water treatment up-regulated mRNA and protein expression of GRP78 and caspase-12.	Water	77-82	heat shock protein 5	Mus musculus	137-142
22526928-7	2012	M1 water exposure up-regulated GRP78 mRNA and protein expression and CHOP mRNA expression, whereas M2 water treatment up-regulated caspase-12 and Bcl-2 mRNA expression.	Water	3-8	heat shock protein 5	Mus musculus	31-36
22526928-7	2012	M1 water exposure up-regulated GRP78 mRNA and protein expression and CHOP mRNA expression, whereas M2 water treatment up-regulated caspase-12 and Bcl-2 mRNA expression.	Water	102-107	B cell leukemia/lymphoma 2	Mus musculus	146-151
22790046-1	2012	The hot-water extracts of Lentinula edodes mycelia(LEM)contain carbohydrates, proteins, phenolic compounds, and lignin digest, which perform various physiological activities.	Water	8-13	lymphocyte expansion molecule	Homo sapiens	51-54
22988636-3	2012	The required delivered O3 dose to achieve 90% removal of atrazine in the tap water from the DTU campus was 3.5 mg/L, which produced 130-170 microg/L BrO3(-).	Water	77-82	SEC14 like lipid binding 2	Homo sapiens	73-76
22321167-4	2012	Inversely, the more severe elevations of hepatic water-soluble parts of TC and TG were found in the HFD+CS group, as the elevations of low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol in liver and serum, tumor necrosis factor-alpha, interleukin-1beta and malondialdehyde in liver.	Water	49-54	tumor necrosis factor	Rattus norvegicus	233-260
22321167-4	2012	Inversely, the more severe elevations of hepatic water-soluble parts of TC and TG were found in the HFD+CS group, as the elevations of low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol in liver and serum, tumor necrosis factor-alpha, interleukin-1beta and malondialdehyde in liver.	Water	49-54	interleukin 1 beta	Rattus norvegicus	262-279
23002604-7	2012	There were a variety of factors that influenced the temporal and spatial variations of the major ions in the Nam Co Lake, such as evaporation, precipitation, pH values, etc., among which, evaporation was the most important controlling factor, causing the increasing Na+ concentration and decreasing Ca2+ concentration in the lake water.	Water	330-335	SH3 and cysteine rich domain 3	Homo sapiens	109-112
23776817-1	2012	Arginine vasopressin (AVP) plays an important role in water and sodium homeostasis.	Water	54-59	arginine vasopressin	Homo sapiens	9-20
22712789-1	2012	Water retention in the kidney is known to be an active phenomenon, controlled by a neuropeptide: vasopressin.	Water	0-5	arginine vasopressin	Homo sapiens	97-108
24250503-7	2012	Very good correlation (r = 0.91; water-ethanol solvent system) between the chromatographically obtained hydrophobicity parameters and calculated log p values confirmed the selection of ACE inhibitors since lisinopril and quinapril were on the opposite sites of linear relationship.	Water	33-38	angiotensin I converting enzyme	Homo sapiens	185-188
22894486-5	2012	By way of illustration, we introduce the use of lipids to coat and functionalize these nanoparticles, rendering them water dispersible and readily conjugated to biologically relevant ligands, in this case epidermal growth factor receptor antibody.	Water	117-122	epidermal growth factor receptor	Homo sapiens	205-237
22375892-6	2012	consumed significantly less water than controls in response to a subsequent, dipsogenic dose of angiotensin II, or upon return of water bottles after 18 h of fluid restriction (food present), or in response to a hypertonic challenge.	Water	28-33	angiotensinogen	Rattus norvegicus	96-110
22270756-1	2012	PURPOSE: This research was designed to investigate the feasibility of converting the dinitrotoluene sulfonates (DNTS) in TNT red water into the corresponding aromatic amino compounds using nanoscale zerovalent iron (NZVI).	Water	129-134	chromosome 16 open reading frame 82	Homo sapiens	121-124
22270756-7	2012	Both 2,4-DNT-3-sulfonate (2,220 mg L(-1)) and 2,4-DNT-5-sulfonate (3,270 mg L(-1)) in TNT red water underwent a pseudo-first-order transformation when mixed with NZVI at room temperature and near-neutral pH.	Water	94-99	chromosome 16 open reading frame 82	Homo sapiens	86-89
22622010-3	2012	Therefore, the binding dynamics and involved molecular interactions between VWF A1 domain and GPIbalpha in both water and physiological saline are investigated using molecular dynamics simulations and all-atom models.	Water	112-117	von Willebrand factor	Homo sapiens	76-79
22712789-2	2012	Water excretion was assumed to be a passive phenomenon, as a result of vasopressin release blockade.	Water	0-5	arginine vasopressin	Homo sapiens	71-82
22712789-3	2012	This simplistic view is incorrect because water excretion is also controlled by a diuretic neuropeptide, apelin, produced not only by several peripheral tissues, but also by hypothalamic neurones, in particular the vasopressin ones projecting to the posterior pituitary.	Water	42-47	apelin	Homo sapiens	105-111
22712789-3	2012	This simplistic view is incorrect because water excretion is also controlled by a diuretic neuropeptide, apelin, produced not only by several peripheral tissues, but also by hypothalamic neurones, in particular the vasopressin ones projecting to the posterior pituitary.	Water	42-47	arginine vasopressin	Homo sapiens	215-226
22521259-13	2012	In addition, the pancreatic water content was reduced in mice treated with PPAR-beta/delta agonist.	Water	28-33	peroxisome proliferator activator receptor delta	Mus musculus	75-84
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Water	39-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	211-215
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Water	39-44	nitric oxide synthase 2	Rattus norvegicus	272-276
22285066-6	2012	Water containing the most elevated concentrations of As are mature Na-Cl fluids with relatively low sulfate content and As concentrations reaching up to 73.6 mg L-1 (Los Humeros geothermal field in Mexico), but more commonly ranging from a few mg L-1 to tens of mg L-1.	Water	0-5	immunoglobulin kappa variable 1-16	Homo sapiens	161-164
22285066-6	2012	Water containing the most elevated concentrations of As are mature Na-Cl fluids with relatively low sulfate content and As concentrations reaching up to 73.6 mg L-1 (Los Humeros geothermal field in Mexico), but more commonly ranging from a few mg L-1 to tens of mg L-1.	Water	0-5	immunoglobulin kappa variable 1-16	Homo sapiens	247-250
22285066-6	2012	Water containing the most elevated concentrations of As are mature Na-Cl fluids with relatively low sulfate content and As concentrations reaching up to 73.6 mg L-1 (Los Humeros geothermal field in Mexico), but more commonly ranging from a few mg L-1 to tens of mg L-1.	Water	0-5	immunoglobulin kappa variable 1-16	Homo sapiens	247-250
22699378-1	2012	The protease corin generates atrial natriuretic peptide and affects blood pressure and salt-water homeostasis.	Water	92-97	corin, serine peptidase	Mus musculus	13-18
22699378-2	2012	Under dietary salt challenge, corin knockout mice show blood pressure exacerbation and significant weight gain due to water and salt retention.	Water	118-123	corin, serine peptidase	Mus musculus	30-35
22297805-5	2012	Plasma ANP inhibits the basolateral Na(+)/K(+)-ATPase and may therefore reduce epithelial water absorption.	Water	90-95	natriuretic peptide A	Homo sapiens	7-10
22297805-7	2012	AVP stimulates the basolateral Na(+)/K(+)/2Cl(-) exchanger, thereby increasing Cl(-) secretion, reducing Na(+) absorption, and promoting basolateral to luminal water flux.	Water	160-165	arginine vasopressin	Homo sapiens	0-3
21924224-0	2012	Nanoemulsions as self-emulsified drug delivery carriers for enhanced permeability of the poorly water-soluble selective beta1-adrenoreceptor blocker Talinolol.	Water	96-101	adrenoceptor beta 1	Rattus norvegicus	120-140
22742602-1	2012	The water-soluble vitamins B6, B12 and C play important roles in maternal health as well as fetal development and physiology during gestation.	Water	4-9	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	31-34
23074831-7	2012	We suggest that chronic reduction of ET-1 synthesis in the kidney might lead to water and salt retention.	Water	80-85	endothelin 1	Rattus norvegicus	37-41
22697787-7	2012	Noteworthy, Thr1-O(gamma) can be activated directly by Thr1-N(z) to form the zwitterionic intermediate (with a free energy barrier of only 9.9 kcal/mol), and water cannot assist the rate-determining step, which is remarkably different from the previous perception that a water molecule should mediate the activation process.	Water	158-163	thyroid hormone receptor beta	Homo sapiens	12-16
22562518-11	2012	CONCLUSIONS: AICAR attenuates EAU by preventing generation of Ag-specific Th1 and Th17 cells.	Water	30-33	negative elongation factor complex member C/D, Th1l	Mus musculus	74-77
22697787-7	2012	Noteworthy, Thr1-O(gamma) can be activated directly by Thr1-N(z) to form the zwitterionic intermediate (with a free energy barrier of only 9.9 kcal/mol), and water cannot assist the rate-determining step, which is remarkably different from the previous perception that a water molecule should mediate the activation process.	Water	158-163	thyroid hormone receptor beta	Homo sapiens	55-59
22697787-7	2012	Noteworthy, Thr1-O(gamma) can be activated directly by Thr1-N(z) to form the zwitterionic intermediate (with a free energy barrier of only 9.9 kcal/mol), and water cannot assist the rate-determining step, which is remarkably different from the previous perception that a water molecule should mediate the activation process.	Water	271-276	thyroid hormone receptor beta	Homo sapiens	12-16
22697787-7	2012	Noteworthy, Thr1-O(gamma) can be activated directly by Thr1-N(z) to form the zwitterionic intermediate (with a free energy barrier of only 9.9 kcal/mol), and water cannot assist the rate-determining step, which is remarkably different from the previous perception that a water molecule should mediate the activation process.	Water	271-276	thyroid hormone receptor beta	Homo sapiens	55-59
22534204-3	2012	For every 1-unit increase in log-transformed well water arsenic (ln mug/L) and urinary arsenic (ln mug/g creatinine), plasma soluble VCAM-1 was 1.02 (95% confidence interval: 1.01, 1.03) and 1.04 (95% confidence interval: 1.01, 1.07) times greater, respectively.	Water	50-55	vascular cell adhesion molecule 1	Homo sapiens	133-139
22548282-2	2012	Compared with Cu(I)-catalyzed click chemistry, this metal-free strategy provides the following advantages for Cu-64 labeling of the core of SCK-NPs: (1) elimination of copper exchange between nonradioactive Cu in the catalyst and DOTA-chelated Cu-64; (2) elimination of the internal click reactions between the azide and acetylene groups in the same NPs; and (3) increased efficiency of the click reaction because water-soluble Cu(I) does not need to reach the hydrophobic core of the NPs.	Water	414-419	SHC adaptor protein 2	Homo sapiens	140-143
22484111-5	2012	The salt appetite induced by an LV injection of angiotensin II (Ang II) (10 ng) was also blocked by Nor-BNI injections into the LV, while no significant change was observed in water intake.	Water	176-181	angiotensinogen	Rattus norvegicus	64-70
22521743-1	2012	Catalase, an antioxidant and hydroperoxidase enzyme protects the cellular environment from harmful effects of hydrogen peroxide by facilitating its degradation to oxygen and water.	Water	174-179	catalase	Homo sapiens	0-8
22704463-10	2012	Serum insulin was higher with the chews than both raisins and water (5.1 +- 2.0, 3.1 +- 0.8, 1.9 +- 0.6 uU ml-1 for chews, raisins and water respectively).	Water	135-140	insulin	Homo sapiens	6-13
22534204-2	2012	Both well water arsenic and urinary arsenic were positively associated with plasma levels of soluble VCAM-1.	Water	10-15	vascular cell adhesion molecule 1	Homo sapiens	101-107
22552398-1	2012	The first electronic transition (A X) of liquid water was studied from the perspective of the hydration of cations by analyzing the attenuated total reflection far-ultraviolet (ATR-FUV) spectra of the Group I, II, and XIII metal nitrate electrolyte solutions.	Water	48-53	ATR serine/threonine kinase	Homo sapiens	177-180
22578697-2	2012	The ability of magnetite (Fe(3)O(4)) to activate persulfate (PS) and H(2)O(2) for the oxidation of IBP at near neutral pH was evaluated as well.	Water	69-74	DEF6 guanine nucleotide exchange factor	Homo sapiens	99-102
22578697-9	2012	Finally, several of the degradation products formed during oxidation of IBP in the presence of H(2)O(2) and Na(2)S(2)O(8) (activated by Fe(2+)) were identified.	Water	95-100	DEF6 guanine nucleotide exchange factor	Homo sapiens	72-75
22552398-7	2012	The calculated transition energy spreads of the water-cation complexes directly correlate with the widths of the A X transition bands measured by ATR-FUV spectroscopy.	Water	48-53	ATR serine/threonine kinase	Homo sapiens	146-149
22554415-6	2012	Application of the method to water from three drinking water treatment plants in Western Australia indicating N-DBP formation did occur, with increased detections after chlorination.	Water	29-34	D-box binding PAR bZIP transcription factor	Homo sapiens	112-115
22540123-2	2012	The process consists of a one-step preparation of a novel triazine type glycosyl donor in water and the subsequent transglycosylation to a galactose derivative catalysed by alpha-N-acetylglucosaminidase.	Water	90-95	N-acetyl-alpha-glucosaminidase	Homo sapiens	173-202
22671585-8	2012	In kidney proximal tubules, claudin-2, claudin-10, and claudin-17 allow for paracellular reabsorption of sodium, chloride, and water.	Water	127-132	claudin 10	Homo sapiens	39-49
21885158-4	2012	Patients undergoing anti-TNF treatment may be at increased risk for developing opportunistic infections during construction work, renovations, or water supply perturbations and require specific preventive measures.	Water	146-151	tumor necrosis factor	Homo sapiens	25-28
22587454-3	2012	We report results of constant temperature all-atom molecular dynamics simulations in explicit water of the dynamics of monomeric Abeta(21-30) and its Dutch [Glu22Gln], Arctic [Glu22Gly], and Iowa [Asp23Asn] isoforms that are associated with familial forms of cerebral amyloid angiopathy and AD.	Water	94-99	amyloid beta precursor protein	Homo sapiens	129-134
22575975-2	2012	METHODS: Initially, the crude water and methanol extracts were probed for their capacity to trigger immune cells" NADPH oxidase and MPO-dependent activities as measured by lucigenin- and luminol-amplified chemiluminescence, respectively; as compared to receptor-dependent (serum opsonised zymosan- OPZ) or receptor-independent phorbol myristerate acetate (PMA).	Water	30-35	myeloperoxidase	Homo sapiens	132-135
22671585-8	2012	In kidney proximal tubules, claudin-2, claudin-10, and claudin-17 allow for paracellular reabsorption of sodium, chloride, and water.	Water	127-132	claudin 2	Homo sapiens	28-37
22020536-6	2012	Aquaporin 1 (AQP1) is a cell membrane channel involved in water transport, cell motility, and proliferation.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
22840579-7	2012	Compared to the control area, the concentrations of Pb, Hg, As, BPA, DEP, and DBP in the drinking water were significantly higher than in the polluted area (P&lt;0.05).	Water	98-103	D-box binding PAR bZIP transcription factor	Homo sapiens	78-81
22020536-6	2012	Aquaporin 1 (AQP1) is a cell membrane channel involved in water transport, cell motility, and proliferation.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
22020536-14	2012	RESULTS: We demonstrated expression of AQP1 in normal and neoplastic mesothelium at the apical aspect of the cell, in keeping with a role in water transport.	Water	141-146	aquaporin 1 (Colton blood group)	Homo sapiens	39-43
22405471-0	2012	Adsorption of bovine serum albumin on nano and bulk oxide particles in deionized water.	Water	81-86	albumin	Homo sapiens	21-34
22356870-1	2012	The insulin loaded nanoparticles composed of poly (lactic-co-glycolic acid) (PLGA) and hydroxypropyl methylcellulose phthalate (HP55) were prepared via the emulsions solvent diffusion method with two different solvents, namely, DMSO and acetone/water.	Water	245-250	insulin	Homo sapiens	4-11
22356870-7	2012	However, for the nanoparticles prepared with acetone/water, the release of insulin was pH-dependent.	Water	53-58	insulin	Homo sapiens	75-82
26069764-1	2012	It is clinically useful to distinguish between two types of hereditary nephrogenic diabetes insipidus (NDI): a "pure" type characterized by loss of water only and a complex type characterized by loss of water and ions.	Water	148-153	arginine vasopressin receptor 2	Homo sapiens	103-106
26069764-1	2012	It is clinically useful to distinguish between two types of hereditary nephrogenic diabetes insipidus (NDI): a "pure" type characterized by loss of water only and a complex type characterized by loss of water and ions.	Water	203-208	arginine vasopressin receptor 2	Homo sapiens	103-106
26069764-2	2012	Patients with congenital NDI bearing mutations in the vasopressin 2 receptor gene, AVPR2, or in the aquaporin-2 gene, AQP2, have a pure NDI phenotype with loss of water but normal conservation of sodium, potassium, chloride and calcium.	Water	163-168	arginine vasopressin receptor 2	Homo sapiens	25-28
22327329-7	2012	These results indicate that the endogenous rat UII system may influence renal sodium and water excretion before the onset of full urine concentrating capacity in the SD rat.	Water	89-94	urotensin 2	Rattus norvegicus	47-50
22607296-5	2012	METHODS:   The effect of concomitant treatment with a PPARalpha agonist on retinoid dermatitis in hairless mouse epidermis was evaluated by measuring transepidermal water loss, epidermal histology, and cytokine expression.	Water	165-170	peroxisome proliferator activated receptor alpha	Mus musculus	54-63
22083165-9	2012	A few dynamical conformations or transition states involving direct (His159 ND1...Asp158 OD1) and water-mediated (His159 ND1...W(2)...Asp158 OD1) hydrogen-bonded complexes are envisaged from these studies.	Water	98-103	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	76-79
22083165-9	2012	A few dynamical conformations or transition states involving direct (His159 ND1...Asp158 OD1) and water-mediated (His159 ND1...W(2)...Asp158 OD1) hydrogen-bonded complexes are envisaged from these studies.	Water	98-103	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	121-124
22482880-8	2012	The adsorption of 1.35 ppm Cd(II) was 72+-6% in well-water, and the adsorption of 0.50 ppm Pb(II) was 62+-5% in tap-water.	Water	116-121	submaxillary gland androgen regulated protein 3B	Homo sapiens	91-97
22475023-1	2012	BACKGROUND: Catalase catalyzes the reduction of H(2)O(2) to water and it can also remove organic hydroperoxides.	Water	60-65	catalase	Rattus norvegicus	12-20
28517292-4	2012	Ren is described by the Burlin-theory and because of dissimilarities between the detector-material and water, will have energy dependent correction factors which convert Ren into the clinically relevant DW,Qo=MQo x ND,W,Qo.	Water	103-108	renin	Homo sapiens	0-3
28517292-4	2012	Ren is described by the Burlin-theory and because of dissimilarities between the detector-material and water, will have energy dependent correction factors which convert Ren into the clinically relevant DW,Qo=MQo x ND,W,Qo.	Water	103-108	renin	Homo sapiens	170-173
22691352-9	2012	RESULTS: Acute immobilization and cold water-immersion stress reduced IL-2 level,  and increased IL-6 and TNF-alpha level at different time points (0,  30,  60 and 120 min) after stress,  which was most obvious at 30 min.	Water	39-44	interleukin 6	Rattus norvegicus	97-101
22691352-9	2012	RESULTS: Acute immobilization and cold water-immersion stress reduced IL-2 level,  and increased IL-6 and TNF-alpha level at different time points (0,  30,  60 and 120 min) after stress,  which was most obvious at 30 min.	Water	39-44	tumor necrosis factor	Rattus norvegicus	106-115
22691352-10	2012	Oral administration (gavage) of compound nutrients was found to moderate the acute immobilization and cold water-immersion stress-induced changes in serum IL-2,  IL-6 and TNF-alpha,  which was also most significant at 30 min after stress.	Water	107-112	interleukin 6	Rattus norvegicus	162-166
22691352-10	2012	Oral administration (gavage) of compound nutrients was found to moderate the acute immobilization and cold water-immersion stress-induced changes in serum IL-2,  IL-6 and TNF-alpha,  which was also most significant at 30 min after stress.	Water	107-112	tumor necrosis factor	Rattus norvegicus	171-180
22405967-2	2012	The aim of this study was to investigate the effect of Eudragit E/HCl (E-SD) on the reprecipitation of a poorly water-soluble drug, tacrolimus.	Water	112-117	esterase D	Homo sapiens	71-75
22524681-4	2012	The obtained results also suggest that the PAC model of acetone is likely to be fully miscible with other water models, at least with SPC and TIP4P, as well.	Water	106-111	proline rich protein gene cluster	Homo sapiens	134-137
22500887-5	2012	Examination of the dimer interface, focusing on the protein-DNA interactions, including involvement of water molecules, has revealed the key residues contributing to the recognition events involved in STAT3 protein-DNA interactions.	Water	103-108	signal transducer and activator of transcription 3	Homo sapiens	201-206
22641344-3	2012	In this paper, we used membrane-embedded integrin beta3 TMDs bearing environmentally sensitive fluorophores at inner or outer membrane water interfaces to monitor talin-induced beta3 TMD motion in model membranes.	Water	135-140	integrin subunit beta 3	Homo sapiens	41-55
22521646-2	2012	X-ray crystallographic data of the initial lead compound cocrystallised with p38alpha was crucial in order to uncover a unique binding mode of the inhibitor to the hinge region via a pair of water molecules.	Water	191-196	mitogen-activated protein kinase 14	Homo sapiens	77-85
22530646-3	2012	Therefore, we have addressed the adsorption of the model protein bovine serum albumin (BSA) at the air-water interface with vibrational sum-frequency generation (SFG) and ellipsometry.	Water	103-108	albumin	Homo sapiens	72-85
22366545-1	2012	In the present study, we investigate the impact of a tightly bound water molecule on ligand binding in the S1 pocket of thrombin.	Water	67-72	coagulation factor II, thrombin	Homo sapiens	120-128
22460710-3	2012	The antidiuretic hormone vasopressin (VP) and its receptor, the V2R, play a central role in regulating the urinary concentrating mechanism by stimulating accumulation of the aquaporin 2 (AQP2) water channel in the apical membrane of collecting duct principal cells.	Water	193-198	arginine vasopressin	Homo sapiens	25-36
22460710-3	2012	The antidiuretic hormone vasopressin (VP) and its receptor, the V2R, play a central role in regulating the urinary concentrating mechanism by stimulating accumulation of the aquaporin 2 (AQP2) water channel in the apical membrane of collecting duct principal cells.	Water	193-198	arginine vasopressin	Homo sapiens	38-40
22573813-7	2012	The studies reveal how TDG binds and positions the nucleophile (water) and uncover a previously unrecognized catalytic residue (Thr197).	Water	64-69	thymine DNA glycosylase	Homo sapiens	23-26
22497264-4	2012	The SF approximation is also tested for the SPC/Fw model of liquid water at room temperature, showing good agreement with both the Wolf and the particle mesh Ewald methods; this confirms previous findings [Fennell, C. J.; Gezelter, J. D. J. Chem.	Water	67-72	proline rich protein gene cluster	Homo sapiens	44-47
22364710-2	2012	It was clarified that the interaction between carbonyl/carboxylic acid groups of PCL and the HAp nanoparticles at an oil-water interface played a crucial role in the preparation of the stable Pickering-type emulsions and the HAp nanoparticle-armored microspheres.	Water	121-126	retinoic acid receptor beta	Homo sapiens	93-96
22490053-10	2012	In particular the novel peptide P(HD2) forms a unique octadentate Tb(3+) complex with femtomolar stability in water and an improvement of the luminescence properties with respect to the trisaquo TbP(22) complex by a factor of 4.	Water	110-115	histone deacetylase 2	Homo sapiens	32-37
22426160-5	2012	Simultaneously, exposure to Rg3 suppressed expression of the aquaporin 1 (AQP1) water channel protein, which has previously been reported to be involved in cell migration.	Water	80-85	aquaporin 1 (Colton blood group)	Homo sapiens	61-72
22426160-5	2012	Simultaneously, exposure to Rg3 suppressed expression of the aquaporin 1 (AQP1) water channel protein, which has previously been reported to be involved in cell migration.	Water	80-85	aquaporin 1 (Colton blood group)	Homo sapiens	74-78
22483914-9	2012	The method was successfully applied to the determination of the As(V) content in a ground water sample.	Water	90-95	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	64-69
22328161-1	2012	The collection of fog water is a simple and sustainable technology to obtain fresh water for afforestation, gardening, and as a drinking water source for human and animal consumption.	Water	22-27	zinc finger protein, FOG family member 1	Homo sapiens	18-21
22441138-1	2012	Magnetite-filled micelles capture fac-[M(OH(2))(3)(CO)(3)](+) complexes (M = (99m)Tc, Re), creating versatile self-assembled constructs for multimodal SPECT/MR/optical imaging and radiopharmaceutical guided delivery.	Water	41-47	FA complementation group C	Homo sapiens	34-37
22328161-1	2012	The collection of fog water is a simple and sustainable technology to obtain fresh water for afforestation, gardening, and as a drinking water source for human and animal consumption.	Water	83-88	zinc finger protein, FOG family member 1	Homo sapiens	18-21
22328161-1	2012	The collection of fog water is a simple and sustainable technology to obtain fresh water for afforestation, gardening, and as a drinking water source for human and animal consumption.	Water	83-88	zinc finger protein, FOG family member 1	Homo sapiens	18-21
22328161-2	2012	In regions where fresh water is sparse and fog frequently occurs, it is feasible to set up a passive mesh system for fog water collection.	Water	23-28	zinc finger protein, FOG family member 1	Homo sapiens	117-120
22300899-1	2012	Complexation of zwitterionic lipid, dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and protein, bovine serum albumin (BSA) at the air-water interface has been studied by surface pressure (pi) - mean molecular area (A) isotherms and X-ray reflectivity.	Water	134-139	albumin	Homo sapiens	103-116
22350385-4	2012	Aromatase (cytochrome P450 19 enzyme, CYP19) inhibitory activity was measured by a tritiated water release assay and by direct measurement of bio-transformed steroids using the tritium labeled substrate (3)H-androst-4-ene-3,17-dione.	Water	93-98	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	38-43
22383251-1	2012	Three heterocyclic systems were selected as potential bioisosteres of the amide linker for a series of 1,6-disubstituted-4-quinolone-3-carboxamides, which are potent and selective CB2 ligands that exhibit poor water solubility, with the aim of improving their physicochemical profile and also of clarifying properties of importance for amide bond mimicry.	Water	210-215	cannabinoid receptor 2 (macrophage)	Mus musculus	180-183
22387469-9	2012	Indeed, PON1"s active site shows a remarkable level of networking and versatility whereby multiple residues share the same task and individual active-site residues perform multiple tasks (e.g., binding the catalytic calcium and activating the hydrolytic water).	Water	254-259	paraoxonase 1	Homo sapiens	8-12
22251623-7	2012	Other genes were induced by all types of water samples, although the induction potential was stronger in OSPW most of the time (e.g., VTG gene was expressed nearly 15-fold by surface waters from the lake and river samples but increased to a maximum of 31-fold in OSPW).	Water	41-46	vitellogenin	Oncorhynchus mykiss	134-137
22057851-8	2012	CONCLUSION: The method has been applied for the preconcentration of trace amount of Pb(II) in environmental water samples with satisfying results.	Water	108-113	submaxillary gland androgen regulated protein 3B	Homo sapiens	84-90
22410815-7	2012	RESULTS: GLP-1 area under the curve (AUC) was 43% higher after ingestion of diet soda versus carbonated water in individuals with type 1 diabetes (P = 0.020), similar to control subjects (34% higher, P = 0.029), but was unaffected by diet soda in patients with type 2 diabetes (P = 0.92).	Water	104-109	glucagon	Homo sapiens	9-14
22416082-3	2012	Central h(Gly(2))GLP-2 administration significantly suppressed food and water intake with acute weight loss at 2 h. Further, central h(Gly(2))GLP-2 robustly induced c-Fos activation in the hypothalamic arcuate, dorsomedial, ventromedial, paraventricular, and the lateral hypothalamic nuclei.	Water	72-77	glucagon	Homo sapiens	17-22
22416082-3	2012	Central h(Gly(2))GLP-2 administration significantly suppressed food and water intake with acute weight loss at 2 h. Further, central h(Gly(2))GLP-2 robustly induced c-Fos activation in the hypothalamic arcuate, dorsomedial, ventromedial, paraventricular, and the lateral hypothalamic nuclei.	Water	72-77	glucagon	Homo sapiens	142-147
22774398-2	2012	AIM: The links between the serotonin (5-HT) system and mood prompted us to investigate the 5-HT platelet transporter (SERT), which is considered a reliable, peripheral marker of the same structure present in presynaptic neurons, in 30 healthy volunteers before (t0) and 30 minutes after (t1) thermal balneotherapy with ozonized water, as compared with a similar group who underwent a bath in non-mineral water.	Water	328-333	solute carrier family 6 member 4	Homo sapiens	118-122
22774398-2	2012	AIM: The links between the serotonin (5-HT) system and mood prompted us to investigate the 5-HT platelet transporter (SERT), which is considered a reliable, peripheral marker of the same structure present in presynaptic neurons, in 30 healthy volunteers before (t0) and 30 minutes after (t1) thermal balneotherapy with ozonized water, as compared with a similar group who underwent a bath in non-mineral water.	Water	404-409	solute carrier family 6 member 4	Homo sapiens	118-122
22774398-6	2012	CONCLUSIONS: The results of this study, while showing a decrease of the dissociation constant (Kd) which is the inverse of affinity constant, of 3H-Par binding to SERT in all subjects after balneotherapy and not in those bathing in normal water, suggest that SERT modifications may be related to a specific effect of ozonized water and, perhaps, also to the increased sense of well-being.	Water	239-244	solute carrier family 6 member 4	Homo sapiens	163-167
22852409-3	2012	The water-soluble hyperbranched polymer (HP) exhibited enhanced fluorescence intensity upon exposure to lectin in the presence of mannose compared to other proteins, such as lysozyme and cytochrome c, because mannose plays a key role in binding both lectin and HP resulting in selective sensing toward lectin.	Water	4-9	cytochrome c, somatic	Homo sapiens	187-199
22351593-3	2012	Our results showed that the contributions of Cys34 and the Met residues to the antioxidant activity of HSA were 61% and 29% against O(2)( -), 68% and 61% against H(2)O(2), 38% and 6% against HO( ), 36% and 13% against HOCl, and 51% and 1% against ( )NO, respectively.	Water	162-167	albumin	Homo sapiens	103-106
22279036-2	2012	We examined the use of water soluble chitosan and polyethyleneimine as a carrier for anti-angiogenic protein, TSP-1 coded, in gene delivery.	Water	23-28	thrombospondin 1	Homo sapiens	110-115
22210893-4	2012	Previously, water-insoluble ceramides were shown to change alternative splicing and decrease SR-protein phosphorylation by activating protein phosphatase-1 (PP1).	Water	12-17	inorganic pyrophosphatase 1	Homo sapiens	134-155
22476625-4	2012	In our studies, in the early phase of EAU, proinflammatory molecules such as tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS) and the subsequent mitochondrial DNA damage, mitochondrial protein alteration, and mitochondrial dysfunction by oxidative stress were observed before retinal inflammatory cell infiltration.	Water	38-41	tumor necrosis factor	Homo sapiens	100-110
22476625-4	2012	In our studies, in the early phase of EAU, proinflammatory molecules such as tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS) and the subsequent mitochondrial DNA damage, mitochondrial protein alteration, and mitochondrial dysfunction by oxidative stress were observed before retinal inflammatory cell infiltration.	Water	38-41	nitric oxide synthase 2	Homo sapiens	115-146
22476625-4	2012	In our studies, in the early phase of EAU, proinflammatory molecules such as tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS) and the subsequent mitochondrial DNA damage, mitochondrial protein alteration, and mitochondrial dysfunction by oxidative stress were observed before retinal inflammatory cell infiltration.	Water	38-41	nitric oxide synthase 2	Homo sapiens	148-152
22394692-7	2012	Infarct volume, water content and neurological deficits were significantly reduced when VEGF was given at 2 and 3h after injury.	Water	16-21	vascular endothelial growth factor A	Homo sapiens	88-92
22287624-0	2012	Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation.	Water	95-100	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	23-28
22210893-4	2012	Previously, water-insoluble ceramides were shown to change alternative splicing and decrease SR-protein phosphorylation by activating protein phosphatase-1 (PP1).	Water	12-17	inorganic pyrophosphatase 1	Homo sapiens	157-160
22415556-3	2012	LaCoO(3), which stabilizes Co(III) species in the perovskite structure, exhibited the highest catalytic activity in the photocatalytic water oxidation compared with CoWO(4), Co(3)O(4) and La(0.7)Sr(0.3)CoO(3) which contain Co(II) or Co(IV) species in the matrices.	Water	135-140	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	27-34
22436048-9	2012	This may cause hyperactivation of the cystic fibrosis transmembrane regulator (CFTR), leading to increased chloride and water secretion from the enterocytes, and may thus explain the chronic diarrhea in the affected family members.	Water	120-125	CF transmembrane conductance regulator	Homo sapiens	38-77
22396030-0	2012	A novel chemical ionization reagent ion for organic analytes: the aquachloromanganese(II) cation [ClMn(H2O)+].	Water	103-106	calmin	Homo sapiens	98-102
22396030-1	2012	The reactivity of ClMn(H(2)O)(+) towards small organic compounds (L) was examined in a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer.	Water	23-29	calmin	Homo sapiens	18-22
22396030-3	2012	All the reactions lead to the formation of the ClMn(H(2)O)(L)(+) complex, which dissociates by loss of the H(2)O molecule.	Water	52-57	calmin	Homo sapiens	47-51
22396030-5	2012	Electron transfer was also observed between ClMn(H(2)O)(+) and compounds with low ionization energies (IE), to form the molecular ion (L(+ )) of the analyte.	Water	49-54	calmin	Homo sapiens	44-48
22559488-7	2012	When d(H   H) and r(O   H) are small (e.g., d(H   H) &lt; 2.0 A and r(O   H) &lt; 1.62 A), the repulsion between the two neighbouring atoms increases the total energy of the two water molecules dramatically and apparently weakens the binding of the water dimer.	Water	178-183	desert hedgehog signaling molecule	Homo sapiens	5-12
22559488-7	2012	When d(H   H) and r(O   H) are small (e.g., d(H   H) &lt; 2.0 A and r(O   H) &lt; 1.62 A), the repulsion between the two neighbouring atoms increases the total energy of the two water molecules dramatically and apparently weakens the binding of the water dimer.	Water	178-183	desert hedgehog signaling molecule	Homo sapiens	44-51
22559488-7	2012	When d(H   H) and r(O   H) are small (e.g., d(H   H) &lt; 2.0 A and r(O   H) &lt; 1.62 A), the repulsion between the two neighbouring atoms increases the total energy of the two water molecules dramatically and apparently weakens the binding of the water dimer.	Water	249-254	desert hedgehog signaling molecule	Homo sapiens	5-12
22559488-7	2012	When d(H   H) and r(O   H) are small (e.g., d(H   H) &lt; 2.0 A and r(O   H) &lt; 1.62 A), the repulsion between the two neighbouring atoms increases the total energy of the two water molecules dramatically and apparently weakens the binding of the water dimer.	Water	249-254	desert hedgehog signaling molecule	Homo sapiens	44-51
22559492-7	2012	The proposed methods are validated by calculating the chemical potentials of the Lennard-Jones fluid and extended simple point-charge (SPC/E) water, and results show a high level of agreement with respective equations of state.	Water	142-147	proline rich protein gene cluster	Homo sapiens	135-138
22717436-5	2012	The water-soluble p-sulfonatocalix[4]arene is shown to bind the lysine-rich cytochrome c at three different sites.	Water	4-9	cytochrome c, somatic	Homo sapiens	76-88
22436048-9	2012	This may cause hyperactivation of the cystic fibrosis transmembrane regulator (CFTR), leading to increased chloride and water secretion from the enterocytes, and may thus explain the chronic diarrhea in the affected family members.	Water	120-125	CF transmembrane conductance regulator	Homo sapiens	79-83
22440675-1	2012	Although plaques composed of the amyloid beta-protein (Abeta) are considered a defining feature of Alzheimer"s disease (AD), they are also found in cognitively normal individuals and extensive evidence suggests that non-plaque, water-soluble forms of Abeta may play a role in AD pathogenesis.	Water	228-233	amyloid beta precursor protein	Homo sapiens	55-60
22416024-5	2012	The deprotonations of (Me)OH and (pMe)OH yield the corresponding phenolate species ((Me)O)(-) and ((pMe)O)(-), respectively, whilst that of the previously reported (H)OH (analogous to (Me)OH but lacking the N-methyl group) produces an unprecedented hydrogen-bonded phenol benzimidazolate species, as evidenced by its X-ray structure.	Water	164-169	cystatin B	Homo sapiens	34-37
22416024-5	2012	The deprotonations of (Me)OH and (pMe)OH yield the corresponding phenolate species ((Me)O)(-) and ((pMe)O)(-), respectively, whilst that of the previously reported (H)OH (analogous to (Me)OH but lacking the N-methyl group) produces an unprecedented hydrogen-bonded phenol benzimidazolate species, as evidenced by its X-ray structure.	Water	164-169	cystatin B	Homo sapiens	100-103
22503109-1	2012	A new water-soluble Pybox ligand, 1, has been synthesized and found to crystallize in the monoclinic P2(1)/n space group with unit cell parameters a = 6.0936(1) A, b = 20.5265(4) A, c = 12.0548(2) A, and beta = 90.614(1) .	Water	6-11	cyclin dependent kinase inhibitor 1A	Homo sapiens	101-106
22440675-1	2012	Although plaques composed of the amyloid beta-protein (Abeta) are considered a defining feature of Alzheimer"s disease (AD), they are also found in cognitively normal individuals and extensive evidence suggests that non-plaque, water-soluble forms of Abeta may play a role in AD pathogenesis.	Water	228-233	amyloid beta precursor protein	Homo sapiens	251-256
22440675-2	2012	However, the relationship between the levels of water-soluble Abeta and the clinical severity of disease has never been investigated.	Water	48-53	amyloid beta precursor protein	Homo sapiens	62-67
22440675-3	2012	Here, we present results of a pilot study designed to examine the levels of water-soluble forms of Abeta in brains of individuals who died at clinically distinct stages of AD.	Water	76-81	amyloid beta precursor protein	Homo sapiens	99-104
22440675-5	2012	We found that water-soluble and detergent-soluble Abeta monomer and SDS-stable dimer were elevated in AD and that the levels of water soluble Abeta did not increase with plaque pathology.	Water	128-133	amyloid beta precursor protein	Homo sapiens	142-147
22440675-8	2012	Consequently, therapeutic targeting of water-soluble Abeta should best benefit individuals in earliest phases of the disease process.	Water	39-44	amyloid beta precursor protein	Homo sapiens	53-58
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	Water	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	Water	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22496554-9	2012	Finally, Psen1 c.548G>T(KI/KI);Psen2(-/-) mice exhibited mild spatial memory deficits in the Morris water maze task.	Water	100-105	presenilin 2	Mus musculus	31-36
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	Water	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22394103-6	2012	These electrokinetic studies, combined with recent XAS studies of catalyst structure, suggest a mechanism for steady state growth at intermediate MeP(i) concentration (1.8-18 mM) involving a rapid solution equilibrium between aquo Co(II) and Co(III) hydroxo species accompanied with a rapid surface equilibrium involving electrolyte dissociation and deprotonation of surface bound water.	Water	381-386	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	242-249
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	Water	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22469064-0	2012	Protein and water dynamics in bovine serum albumin-water mixtures over wide ranges of composition.	Water	51-56	albumin	Homo sapiens	37-50
22469064-1	2012	Dielectric dynamic behavior of bovine serum albumin (BSA)-water mixtures over wide ranges of water fractions, from dry protein until 40 wt % in water, was studied through dielectric relaxation spectroscopy (DRS).	Water	58-63	albumin	Homo sapiens	38-51
22367207-9	2012	The inhibition of miR-378 by its anti-miR protected cardiomyocytes against H(2)O(2) and hypoxia reoxygenation-induced cell death by promoting IGF1R expression and downstream Akt signaling cascade.	Water	75-80	microRNA 378a	Mus musculus	18-25
22367207-9	2012	The inhibition of miR-378 by its anti-miR protected cardiomyocytes against H(2)O(2) and hypoxia reoxygenation-induced cell death by promoting IGF1R expression and downstream Akt signaling cascade.	Water	75-80	microRNA 615	Mus musculus	18-21
22432981-7	2012	Its mediation by a water molecule bound to PPO as a possible mechanism is suggested.	Water	19-24	protoporphyrinogen oxidase	Homo sapiens	43-46
22354076-6	2012	The sensor can selectively detect Hg(2+) in water with the detection limit of 1 muM.	Water	44-49	latexin	Homo sapiens	80-83
22730727-3	2012	Pathological roles of vasopressin in water metabolism: vasopressin agonist and antagonists].	Water	37-42	arginine vasopressin	Homo sapiens	22-33
22361662-0	2012	Water content determination of superdisintegrants by means of ATR-FTIR spectroscopy.	Water	0-5	ATR serine/threonine kinase	Homo sapiens	62-65
22482537-1	2012	The viscosity-temperature relation is determined for the water models SPC/E, TIP4P, TIP4P/Ew, and TIP4P/2005 by considering Poiseuille flow inside a nano-channel using molecular dynamics.	Water	57-62	proline rich protein gene cluster	Homo sapiens	70-73
22361662-1	2012	Water contents of superdisintegrant pharmaceutical excipients were determined by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy using simple linear regression.	Water	0-5	ATR serine/threonine kinase	Homo sapiens	138-141
22329894-4	2012	Dl-PHPB partially reversed the decrease of B-cell CLL/lymphoma 2 (Bcl-2) protein level induced by H(2)O(2).	Water	98-103	BCL2 apoptosis regulator	Homo sapiens	43-64
22329894-4	2012	Dl-PHPB partially reversed the decrease of B-cell CLL/lymphoma 2 (Bcl-2) protein level induced by H(2)O(2).	Water	98-103	BCL2 apoptosis regulator	Homo sapiens	66-71
22356889-3	2012	Water intake induced by intracerebroventricular injection of angiotensin II (ANGII) was suppressed by co-injection of DA in a dose-dependent manner.	Water	0-5	angiotensinogen	Rattus norvegicus	61-75
22481418-1	2012	Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that regulates the transport of ions and the movement of water across the epithelial barrier.	Water	139-144	CF transmembrane conductance regulator	Homo sapiens	0-51
22481418-1	2012	Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that regulates the transport of ions and the movement of water across the epithelial barrier.	Water	139-144	CF transmembrane conductance regulator	Homo sapiens	53-57
22356889-3	2012	Water intake induced by intracerebroventricular injection of angiotensin II (ANGII) was suppressed by co-injection of DA in a dose-dependent manner.	Water	0-5	angiotensinogen	Rattus norvegicus	77-82
22356889-12	2012	This may be a cause of the suppression of ANGII-induced water intake by DA.	Water	56-61	angiotensinogen	Rattus norvegicus	42-47
22154540-6	2012	Interestingly, after water deprivation, urine osmolality was significantly lower in patients compared with unaffected members, suggesting desensitization of the downstream signaling pathway with persistent AVPR2 activation.	Water	21-26	arginine vasopressin receptor 2	Homo sapiens	206-211
22390193-1	2012	Sum frequency generation (SFG) vibrational spectroscopy was used to study the structure of water at cross-linked PEO film interfaces in the presence of human serum albumin (HSA) protein.	Water	91-96	albumin	Homo sapiens	158-185
22248526-2	2012	In addition to increasing the mechanical properties, PGF can also release bioinorganics, as they are water soluble, a property that may be controllably translated into a fully degradable composite.	Water	101-106	placental growth factor	Homo sapiens	53-56
22099058-10	2012	Cevimeline inhibited angiotensin II-induced water intake and neuronal activity in the subfornical organ, which is in contrast to reported effects of pilocarpine.	Water	44-49	angiotensinogen	Rattus norvegicus	21-35
22311646-0	2012	Improvement of tolerance of Saccharomyces cerevisiae to hot-compressed water-treated cellulose by expression of ADH1.	Water	71-76	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	112-116
22311646-9	2012	Finally, the ADH1-overexpressing strain shows a statistically significantly improved fermentation profile in a hot-compressed water-treated cellulose-containing medium.	Water	126-131	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	13-17
21771582-1	2012	Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the mitochondrial electron transport chain (ETC), the reduction of oxygen to water.	Water	162-167	cytochrome c, somatic	Homo sapiens	0-12
21771582-1	2012	Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the mitochondrial electron transport chain (ETC), the reduction of oxygen to water.	Water	162-167	cytochrome c, somatic	Homo sapiens	14-18
21771582-1	2012	Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the mitochondrial electron transport chain (ETC), the reduction of oxygen to water.	Water	162-167	cytochrome c, somatic	Homo sapiens	24-36
22113809-8	2012	This indicates that the total binding free energies calculated for the inhibitor-heme model complexes can be a good descriptor in interpreting the inhibitor binding to CYP3A4 and the relative free energies in the gas phase are mainly responsible for the total binding free energies in water, although the desolvation can be a factor to affect the binding affinity of the inhibitors to CYP3A4.	Water	285-290	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	168-174
22113809-8	2012	This indicates that the total binding free energies calculated for the inhibitor-heme model complexes can be a good descriptor in interpreting the inhibitor binding to CYP3A4 and the relative free energies in the gas phase are mainly responsible for the total binding free energies in water, although the desolvation can be a factor to affect the binding affinity of the inhibitors to CYP3A4.	Water	285-290	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	385-391
22113809-9	2012	From the theozyme analysis of the X-ray structures for ketoconazole- and metyrapone-CYP3A4 complexes, the interaction free energy of the neighboring residues with each inhibitor in the active site is calculated to be about -3 kcal mol(-1) in water, whose the interaction energy and the desolvation free energy change are about -5 and 2 kcal mol(-1) , respectively.	Water	242-247	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-90
22099058-6	2012	In the conscious condition, changes in angiotensin II-induced water intake were observed after cevimeline administration.	Water	62-67	angiotensinogen	Rattus norvegicus	39-53
22209302-0	2012	Study of inhibition mechanism of NO3- on photoreduction of Hg(II) in artificial water.	Water	80-85	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
22057239-13	2012	PYY stimulates absorption of water and electrolytes, and inhibits prostaglandin (PG) E2, and vasoactive intestinal peptide, which stimulates intestinal fluid secretion and is a major regulator of the "ileal brake".	Water	29-34	peptide YY	Homo sapiens	0-3
22154096-0	2012	Monolayer and Brewster angle microscopy study of human serum albumin-dipalmitoyl phosphatidyl choline mixtures at the air-water interface.	Water	122-127	albumin	Homo sapiens	55-68
22115717-5	2012	SH-modified lysozyme showed largely unfolded structure in water and alpha-helical structure in the presence of ethanol.	Water	58-63	lysozyme	Homo sapiens	12-20
22133665-2	2012	A water-soluble polysaccharide named SCP-IIa was isolated from the water extract of the fruit of Schisandra chinensis (Turcz.)	Water	2-7	ATPase, class II, type 9A	Mus musculus	41-44
22133665-2	2012	A water-soluble polysaccharide named SCP-IIa was isolated from the water extract of the fruit of Schisandra chinensis (Turcz.)	Water	67-72	ATPase, class II, type 9A	Mus musculus	41-44
22060896-0	2012	Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation.	Water	123-128	arginine vasopressin	Rattus norvegicus	95-106
22354326-10	2012	These observations suggested that the PLGA-PEG block copolymers nanomicelles have been prepared by a new synthetic route are potent nanocarrier for poorly water-soluble drugs as insulin.	Water	155-160	insulin	Homo sapiens	178-185
22586497-0	2012	Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells.	Water	52-57	RB transcriptional corepressor like 2	Rattus norvegicus	157-162
22330181-1	2012	The antidiuretic hormone vasopressin (VP) promotes water reabsorption from the kidney and levels of circulating VP are normally related linearly to plasma osmolality, aiming to maintain the latter close to a predetermined set point.	Water	51-56	arginine vasopressin	Rattus norvegicus	25-36
22330181-1	2012	The antidiuretic hormone vasopressin (VP) promotes water reabsorption from the kidney and levels of circulating VP are normally related linearly to plasma osmolality, aiming to maintain the latter close to a predetermined set point.	Water	51-56	arginine vasopressin	Rattus norvegicus	38-40
21769482-0	2012	Association between promoter polymorphisms in a key cytoskeletal gene (Ankyrin 1) and intramuscular fat and water-holding capacity in porcine muscle.	Water	108-113	ankyrin-1	Bos taurus	71-80
22350729-1	2012	The effects of the centrally administered neuropeptides orexin-A on water intake and vasopressin (VP) secretion were studied in male Wistar rats (180-250 g).	Water	68-73	hypocretin neuropeptide precursor	Rattus norvegicus	56-64
22350729-5	2012	Increased water consumption was observed after the administration of 30 mug/10 mul orexin-A.	Water	10-15	hypocretin neuropeptide precursor	Rattus norvegicus	83-91
22352796-3	2012	The results reveal a distinct network of three binding site water molecules that yield strikingly similar hydration patterns for EGFR and HER2 in contrast to that of ErbB4, which shows a different pattern with a reduced occupancy at one of the positions.	Water	60-65	epidermal growth factor receptor	Homo sapiens	129-133
22352796-7	2012	Additional simulations with clinically relevant EGFR (C775F, T854A, and T790M) and HER2 (T790I) mutants demonstrate that resistance can also be understood in terms of changes that occur in the binding site water network.	Water	206-211	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-87
22334691-0	2012	Rapid aquaporin translocation regulates cellular water flow: mechanism of hypotonicity-induced subcellular localization of aquaporin 1 water channel.	Water	49-54	aquaporin 1 (Colton blood group)	Homo sapiens	123-134
22334691-0	2012	Rapid aquaporin translocation regulates cellular water flow: mechanism of hypotonicity-induced subcellular localization of aquaporin 1 water channel.	Water	135-140	aquaporin 1 (Colton blood group)	Homo sapiens	123-134
22334691-7	2012	This translocation, which has a direct role in cell volume regulation, occurs within 30 s and is dependent on calmodulin activation and phosphorylation of AQP1 at two threonine residues by protein kinase C. This direct mechanism provides a rationale for the changes in water transport that are required in response to constantly changing local cellular water availability.	Water	269-274	aquaporin 1 (Colton blood group)	Homo sapiens	155-159
22334691-7	2012	This translocation, which has a direct role in cell volume regulation, occurs within 30 s and is dependent on calmodulin activation and phosphorylation of AQP1 at two threonine residues by protein kinase C. This direct mechanism provides a rationale for the changes in water transport that are required in response to constantly changing local cellular water availability.	Water	353-358	aquaporin 1 (Colton blood group)	Homo sapiens	155-159
22352796-3	2012	The results reveal a distinct network of three binding site water molecules that yield strikingly similar hydration patterns for EGFR and HER2 in contrast to that of ErbB4, which shows a different pattern with a reduced occupancy at one of the positions.	Water	60-65	erb-b2 receptor tyrosine kinase 2	Homo sapiens	138-142
22352796-4	2012	The primary cause was traced to a single amino acid change in the binding site (EGFR position 775), involving a swap from C or S (EGFR and HER2) to V (ErbB4), for which the side chain is bulkier, is hydrophobic, and lacks the ability to form a H-bond with water.	Water	256-261	epidermal growth factor receptor	Homo sapiens	80-84
22352796-4	2012	The primary cause was traced to a single amino acid change in the binding site (EGFR position 775), involving a swap from C or S (EGFR and HER2) to V (ErbB4), for which the side chain is bulkier, is hydrophobic, and lacks the ability to form a H-bond with water.	Water	256-261	epidermal growth factor receptor	Homo sapiens	130-134
22352796-4	2012	The primary cause was traced to a single amino acid change in the binding site (EGFR position 775), involving a swap from C or S (EGFR and HER2) to V (ErbB4), for which the side chain is bulkier, is hydrophobic, and lacks the ability to form a H-bond with water.	Water	256-261	erb-b2 receptor tyrosine kinase 2	Homo sapiens	139-143
22352796-7	2012	Additional simulations with clinically relevant EGFR (C775F, T854A, and T790M) and HER2 (T790I) mutants demonstrate that resistance can also be understood in terms of changes that occur in the binding site water network.	Water	206-211	epidermal growth factor receptor	Homo sapiens	48-52
22339158-0	2012	Pd-catalyzed direct arylation of polyfluoroarenes on water under mild conditions using PPh3 ligand.	Water	53-58	caveolin 1	Homo sapiens	87-91
22366086-4	2012	Genes such as Slc2a5, Cdkn1c, Cabp2, Ranbp3, Vwce and Gcgr were induced by force-feeding with fructose compared with glucose or distilled water.	Water	138-143	calcium binding protein 2	Rattus norvegicus	30-35
22366086-4	2012	Genes such as Slc2a5, Cdkn1c, Cabp2, Ranbp3, Vwce and Gcgr were induced by force-feeding with fructose compared with glucose or distilled water.	Water	138-143	von Willebrand factor C and EGF domains	Rattus norvegicus	45-49
22366086-4	2012	Genes such as Slc2a5, Cdkn1c, Cabp2, Ranbp3, Vwce and Gcgr were induced by force-feeding with fructose compared with glucose or distilled water.	Water	138-143	solute carrier family 2 member 5	Rattus norvegicus	14-20
22392116-7	2012	CONCLUSIONS: Increased AQP9 might contribute to clearance of excess water and lactate in the early stage of TBI.	Water	68-73	aquaporin 9	Rattus norvegicus	23-27
22423844-1	2012	Free energy partitioning analysis is employed to explore the driving forces for ions interacting with the water liquid-vapor interface using recently optimized point charge models for the ions and SPC/E water.	Water	106-111	proline rich protein gene cluster	Homo sapiens	197-200
22423844-1	2012	Free energy partitioning analysis is employed to explore the driving forces for ions interacting with the water liquid-vapor interface using recently optimized point charge models for the ions and SPC/E water.	Water	203-208	proline rich protein gene cluster	Homo sapiens	197-200
22423844-5	2012	Shifts of the ion free energies occur in the slab geometry consistent with the SPC/E surface potential of the water liquid-vapor interface.	Water	110-115	proline rich protein gene cluster	Homo sapiens	79-82
22316432-7	2012	With maximum capacities of 51 and 30 mg g(-1) for As(V) and Cr(VI), respectively, these low-cost flowerlike alpha-Fe(2)O(3) nanostructures are an attractive adsorbent for the removal of As(V) and Cr(VI) from water.	Water	208-213	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	186-191
22326022-6	2012	Here we show that increasing cytoplasmic osmolarity through a genetic lesion known to produce elevated levels of soluble sugars, exogenously providing osmolytes in the growth media, or withholding water rescues the msl2-1 msl3-1 leaf epidermal plastid phenotype, producing plastids that resemble the wild-type in shape and size.	Water	197-202	MSCS-like 2	Arabidopsis thaliana	215-219
22130631-1	2012	BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO).	Water	206-211	catalase	Homo sapiens	160-163
22130631-1	2012	BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO).	Water	206-211	myeloperoxidase	Homo sapiens	267-282
22130631-1	2012	BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO).	Water	206-211	myeloperoxidase	Homo sapiens	284-287
22305191-3	2012	In this study, the effects of the water extractable fraction of PSP on the metabolism of model CYP1A2, CYP2D6, CYP2E1 and CYP3A4 probe substrates were investigated in pooled human liver microsomes.	Water	34-39	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	103-109
22305191-3	2012	In this study, the effects of the water extractable fraction of PSP on the metabolism of model CYP1A2, CYP2D6, CYP2E1 and CYP3A4 probe substrates were investigated in pooled human liver microsomes.	Water	34-39	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	111-117
22210751-11	2012	Treatment of ANG II mice with apocynin (10 mmol/l in drinking water), an inhibitor of NAD(P)H oxidase activation, completely inhibited NAD(P)H oxidase activity and improved exercise capacity, mitochondrial respiration, and complex activities in skeletal muscle.	Water	62-67	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	13-19
21946396-4	2012	In vivo studies showed that 100 mug/L MC-LR led to a significant increase in the AChE activity (27%) when zebrafish were exposed to the toxin dissolved in water, but did not cause any significant changes when injected intraperitoneally.	Water	155-160	acetylcholinesterase	Danio rerio	81-85
22192778-3	2012	The constriction region of the pore determining the solute specificity deviates in AQP8 making it permeable to both ammonia and H(2)O(2) in addition to water.	Water	152-157	aquaporin 8	Homo sapiens	83-87
22145952-9	2012	In addition, induction of HO-1 in tumors by the water-soluble macromolecular HO-1 inducer pegylated hemin significantly increased tumor blood flow and Evans blue-albumin accumulation in tumors.	Water	48-53	heme oxygenase 1	Mus musculus	26-30
22145952-9	2012	In addition, induction of HO-1 in tumors by the water-soluble macromolecular HO-1 inducer pegylated hemin significantly increased tumor blood flow and Evans blue-albumin accumulation in tumors.	Water	48-53	heme oxygenase 1	Mus musculus	77-81
22311606-9	2012	The specific interaction between Gln50 and C18 and water-mediated hydrogen bond between Gln50 and T7 were found to be present during almost the entire time of the simulation.	Water	51-56	Bardet-Biedl syndrome 9	Homo sapiens	43-46
22062152-6	2012	The trace metals Cd, Co, Cu, Mn and Ni in most of the water samples collected from Goffa, Kera and Akaki farms also surpassed irrigation water guideline limits, which might be a case for high accumulation of metals in the soils.	Water	54-59	keratocan	Homo sapiens	90-94
22244837-4	2012	In this study, we found that adding 10 muM water-soluble CoQ(10) to the culture medium of clk-1 mutant nematodes that were fed a diet of standard bacteria restored the pharyngeal pumping, defecation and the lifespan to levels that were comparable to those of wild-type animals.	Water	43-48	latexin	Homo sapiens	39-42
21834801-1	2012	BACKGROUND: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a recently described entity, linked to gain-of-function mutations (R137C and R137L) in arginine vasopressin (AVP) gene leading to chronic activation of tubular V2 AVP receptor (V2R) and thus free water reabsorption.	Water	270-275	arginine vasopressin	Homo sapiens	170-181
21834801-1	2012	BACKGROUND: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a recently described entity, linked to gain-of-function mutations (R137C and R137L) in arginine vasopressin (AVP) gene leading to chronic activation of tubular V2 AVP receptor (V2R) and thus free water reabsorption.	Water	270-275	arginine vasopressin receptor 2	Homo sapiens	234-254
22258082-4	2012	Similarly, the activation volume determined for the dissociation of camphor is influenced by the presence of K(+), which reflects changes in the ease of water entering the active site of camphor-bound P450(cam) that depends on the K(+) concentration.	Water	153-158	calmodulin 3	Homo sapiens	201-210
22393940-1	2012	The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel localized primarily at the apical surfaces of epithelial cells lining airway, gut and exocrine glands, where it is responsible for transepithelial salt and water transport.	Water	256-261	CF transmembrane conductance regulator	Homo sapiens	4-55
22393940-1	2012	The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel localized primarily at the apical surfaces of epithelial cells lining airway, gut and exocrine glands, where it is responsible for transepithelial salt and water transport.	Water	256-261	CF transmembrane conductance regulator	Homo sapiens	57-61
22470853-6	2012	They produce aquaresis by their action on vasopressin type 2 (V2R) receptors in the collecting duct and thus increase solute free water excretion.	Water	130-135	arginine vasopressin receptor 2	Homo sapiens	42-65
23115429-10	2012	The rats supplemented with Piper sarmentosum water extract had significantly higher 11beta-HSD1 dehydrogenase activity and lower 11beta-HSD1 expression in the bones.	Water	45-50	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	84-95
23115429-10	2012	The rats supplemented with Piper sarmentosum water extract had significantly higher 11beta-HSD1 dehydrogenase activity and lower 11beta-HSD1 expression in the bones.	Water	45-50	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	129-140
23115429-11	2012	CONCLUSION: The results showed that Piper sarmentosum water extract had the ability to prevent glucocorcoticoid excess in the bones of glucocorticoid-treated adrenalectomized rats through the local modulation of 11beta-HSD1 expression and activity, and may be used as prophylaxis for osteoporosis in patients on long-term glucocorticoid treatment.	Water	54-59	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	212-223
22258082-5	2012	Careful analysis of the components that contribute to the observed volume changes allowed the estimation of the total number of water molecules expelled to the bulk solvent during the binding of camphor to P450(cam) and the subsequent spin transition.	Water	128-133	calmodulin 3	Homo sapiens	206-215
22027579-1	2012	BACKGROUND &amp; AIMS: Tolvaptan is a vasopressin V2-receptor antagonist that improves serum sodium concentration by increasing renal solute-free water excretion.	Water	146-151	arginine vasopressin receptor 2	Homo sapiens	38-61
22250214-0	2012	Cotransport of water by Na+-K+-2Cl- cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2.	Water	15-20	Na-K-2Cl cotransporter 1	Xenopus laevis	81-86
22250214-0	2012	Cotransport of water by Na+-K+-2Cl- cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2.	Water	15-20	solute carrier family 12 member 1 L homeolog	Xenopus laevis	94-99
22303032-8	2012	The relatively high frequency of the low-activity CYP2D6 and COMT genotypes in the population warrants further attention, since consumption of free water following ingestion of MDMA in these individuals may trigger dilutational hyponatraemia and increased risk of syndrome of inappropriate antidiuretic hormone secretion.	Water	148-153	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	50-56
22250214-1	2012	The NKCC1 and NKCC2 isoforms of the mammalian Na+-K+-2Cl- cotransporter were expressed in Xenopus oocytes and the relation between external ion concentration and water fluxes determined.Water fluxes were determined from changes in the oocytes volume and ion fluxes from 86Rb+ uptake.	Water	186-191	solute carrier family 12 member 1	Homo sapiens	14-19
22250214-2	2012	Isotonic increases in external K+ concentration elicited abrupt inward water fluxes in NKCC1; the K+ dependence obeyed one-site kinetics with a K0.5 of 7.5 mM.	Water	71-76	Na-K-2Cl cotransporter 1	Xenopus laevis	87-92
22250214-5	2012	In contrast, NKCC2 did not support water fluxes.Water transport in NKCC1 induced by increases in the external osmolarity had high activation energy and was blocked by bumetanide.	Water	35-40	Na-K-2Cl cotransporter 1	Xenopus laevis	67-72
22250214-5	2012	In contrast, NKCC2 did not support water fluxes.Water transport in NKCC1 induced by increases in the external osmolarity had high activation energy and was blocked by bumetanide.	Water	48-53	solute carrier family 12 member 1 L homeolog	Xenopus laevis	13-18
22250214-5	2012	In contrast, NKCC2 did not support water fluxes.Water transport in NKCC1 induced by increases in the external osmolarity had high activation energy and was blocked by bumetanide.	Water	48-53	Na-K-2Cl cotransporter 1	Xenopus laevis	67-72
22250214-7	2012	This supports the notion of interaction between ions and water in NKCC1 and allows for an estimate of around 600 water molecules transported per turnover of the protein.	Water	57-62	Na-K-2Cl cotransporter 1	Xenopus laevis	66-71
22250214-7	2012	This supports the notion of interaction between ions and water in NKCC1 and allows for an estimate of around 600 water molecules transported per turnover of the protein.	Water	113-118	Na-K-2Cl cotransporter 1	Xenopus laevis	66-71
22250214-9	2012	We conclude that NKCC1 plays a direct role for water balance in most cell types, while NKCC2 fulfils its role in the kidney of transporting ions but not water.	Water	47-52	Na-K-2Cl cotransporter 1	Xenopus laevis	17-22
22645945-6	2012	After vasopressin injection solute-free water reabsorption was 1.5-fold higher in rats fed diet II.	Water	40-45	arginine vasopressin	Rattus norvegicus	6-17
22201047-8	2012	In vitro assay showed that the purified recombinant TT19 increases water solubility of cyanidin (Cya) and cyanidin-3-O-glycoside (C3G).	Water	67-72	glutathione S-transferase phi 12	Arabidopsis thaliana	52-56
21778278-1	2012	BACKGROUND: Recent experimental findings demonstrate vascular endothelial growth factor C (VEGF-C)-mediated water-free storage of salt in the interstitium, which prevents a salt-sensitive blood pressure state.	Water	108-113	vascular endothelial growth factor C	Homo sapiens	53-89
21778278-1	2012	BACKGROUND: Recent experimental findings demonstrate vascular endothelial growth factor C (VEGF-C)-mediated water-free storage of salt in the interstitium, which prevents a salt-sensitive blood pressure state.	Water	108-113	vascular endothelial growth factor C	Homo sapiens	91-97
22437213-5	2012	Arginine vasopressin is elevated in hypervolemic/euvolemic hyponatremia, favoring water reabsorption despite low serum osmolality.	Water	82-87	arginine vasopressin	Homo sapiens	9-20
21730965-8	2012	At baseline, C(-) carriers of IL-6 polymorphism had a significantly higher RMR (P&lt;0.05), free FM (kg), but less total and trunk FM (%), higher body cell mass (BCM), content of TBW (L) and ECW (extracellular water)/ICW ratio compared with C(+) carriers (P&lt;0.001).	Water	210-215	interleukin 6	Homo sapiens	30-34
22568105-17	2012	Given that AQP-9 belongs to an aquaglyceroporin subfamily and allows solutes other than water (e.g., lactate) to cross the plasma membrane, chronic ocular hypertension may perturb this physiological passage of lactate.	Water	88-93	aquaporin 9	Rattus norvegicus	11-16
22587099-6	2012	In turn, the case of the first hydration layers of the lysozyme molecule is shown to be more complicated, but still displaying signs of both kinds of behavior, together with a tendency of the proximal water molecules to hydrogen bond to the protein both as donors and as acceptors.	Water	201-206	lysozyme	Homo sapiens	55-63
22245594-9	2012	Further, before and after adjusting with different covariates, plasma Big ET-1 levels were found to be significantly associated with the water, hair and nail As concentrations of the study subjects.	Water	137-142	endothelin 1	Homo sapiens	74-78
22192708-4	2012	Specifically, rats given a treatment regimen of three icv injections of a large dose of AngII, each separated by 20 min, drink less water in response to a test injection of AngII than do vehicle-treated controls given the same test injection.	Water	132-137	angiotensinogen	Rattus norvegicus	88-93
22611943-2	2012	METHODS: The pesticides were extracted from 1000 ml water sample with the activation of the C18 solid disk membrane.	Water	52-57	Bardet-Biedl syndrome 9	Homo sapiens	92-95
22192708-4	2012	Specifically, rats given a treatment regimen of three icv injections of a large dose of AngII, each separated by 20 min, drink less water in response to a test injection of AngII than do vehicle-treated controls given the same test injection.	Water	132-137	angiotensinogen	Rattus norvegicus	173-178
28348296-9	2012	The work of adhesion of water was very high for the reactively sputtered Y2O3 (54 mJ/m2) and thermally oxidized Y-Y2O3 coatings (43 mJ/m2) compared to the Cd-CdO template assisted Y2O3 coating (7 mJ/m2).	Water	24-29	cell adhesion associated, oncogene regulated	Homo sapiens	158-161
22263580-9	2012	The roles of water molecules in the LLX release from the HDAC1 and HDAC2 enzymes are also discussed.	Water	13-18	histone deacetylase 1	Homo sapiens	57-62
22263580-9	2012	The roles of water molecules in the LLX release from the HDAC1 and HDAC2 enzymes are also discussed.	Water	13-18	histone deacetylase 2	Homo sapiens	67-72
22320214-14	2012	Interestingly, the dissociation of hydrates modeled using the SPC/E water potential does not display the predicted pore-size dependence, and the dissociation mechanisms in this model seem to be quite different than those in the TIP4P-type models.	Water	68-73	proline rich protein gene cluster	Homo sapiens	62-65
22218737-4	2012	The results indicated that the MLC was formed at the reaction condition of 5 mg Ferrocene + 6 mL CCl(4) at 280  C. Electrochemical methods, such as cyclic voltammetry and electrochemical impedance spectroscopy, were used to characterize the layered biosensor and its application for sensitive detection of hydrogen peroxide (H(2)O(2)).	Water	325-330	modulator of VRAC current 1	Homo sapiens	31-34
22263642-1	2012	The human insulin (HI) Langmuir monolayer at the air-water interface was systematically investigated in the presence and absence of Zn(II) ions in the subphase.	Water	53-58	insulin	Homo sapiens	10-17
22088434-4	2012	ANG II also increased water intake and urine output, decreased glomerular filtration rate, increased urinary Na(+) and K(+) excretion, and caused proteinuria, all of which were prevented by TMS.	Water	22-27	angiotensinogen	Rattus norvegicus	0-6
22260793-4	2012	In the water maze, ngr(-/-) mice learned to locate the hidden platform as well as wild type mice, although with slower acquisition.	Water	7-12	reticulon 4 receptor	Mus musculus	19-22
22240735-1	2012	Examination of the aqueous electrochemistry of a Co(II) complex bearing a pentadentate ligand suggests that the catalytic current corresponding to water oxidation is molecular in origin, and does not emanate exclusively from Co-oxide phases formed in situ.	Water	147-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
22155935-4	2012	Such inhibition is predominantly mediated by phospholipase C. We investigated four M channel enhancers (retigabine, flupirtine, zinc pyrithione and H(2)O(2)) for their ability to overcome M channel inhibition via two phospholipase C-mediated mechanisms, namely depletion of membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) and a rise in intracellular Ca(2+) (an action mediated by calmodulin).	Water	148-153	calmodulin 1	Homo sapiens	388-398
22175234-7	2012	Multivalent conjugates additionally containing click-linked water-solubilizing polyethylene glycol groups potently activated A(3)AR in the 5"-methyluronamide, but not 4" truncated series.	Water	60-65	adenosine A3 receptor	Homo sapiens	125-131
22214887-0	2012	Development of a novel in-water vaccination protocol for DNA adenine methylase deficient Salmonella enterica serovar Typhimurium vaccine in adult sheep.	Water	26-31	DNA adenine methylase	Salmonella enterica subsp. enterica serovar Typhimurium	57-78
22260165-2	2012	The functional role of water molecules has been discussed for rhodopsin, the light sensor for twilight vision, on the basis of X-ray crystallography, Fourier transform infrared (FTIR) spectroscopy, and a radiolytic labeling method, but nothing is known about the protein-bound waters in our color visual pigments.	Water	23-28	rhodopsin	Homo sapiens	62-71
22260165-6	2012	The absence of strongly hydrogen-bonded water molecules (O-D stretch at &lt;2400 cm(-1)) is common between rhodopsin and color pigments, which greatly contrasts with the case of proton-pumping microbial rhodopsins.	Water	40-45	rhodopsin	Homo sapiens	107-116
22260165-7	2012	On the other hand, two important differences are observed in water signal between rhodopsin and color pigments.	Water	61-66	rhodopsin	Homo sapiens	82-91
22325688-1	2012	Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) is a novel disease caused by a gain-of-function mutation in the V2 vasopressin receptor (V2R), which results in water overload and hyponatremia.	Water	171-176	arginine vasopressin receptor 2	Homo sapiens	123-151
26596619-2	2012	Yet, how Abeta proteins acquire an aggregation-prone nature during the conformational transitions in water remains elusive.	Water	101-106	amyloid beta precursor protein	Homo sapiens	9-14
26596619-3	2012	Here, we investigate key structural and thermodynamic features of a 42-residue Abeta (Abeta42) protein that seed aggregation based on the fully atomistic, explicit-water molecular dynamics simulations as well as on the integral-equation theory of liquids for solvation thermodynamic analysis.	Water	164-169	amyloid beta precursor protein	Homo sapiens	79-84
22325688-11	2012	In conclusion, this is the first demonstration in a patient with NSIAD caused by a R137L mutation in the V2R that urine AQP2 excretion is inappropriately elevated and does not suppress normally with water loading.	Water	199-204	arginine vasopressin receptor 2	Homo sapiens	105-108
22201548-0	2012	Conformational changes of alpha-lactalbumin adsorbed at oil-water interfaces: interplay between protein structure and emulsion stability.	Water	60-65	lactalbumin alpha	Homo sapiens	26-43
22166099-7	2012	Water-soluble compounds are predominantly observed as sodium adducts in nano-DESI spectra indicating that addition of sodium to the solvent may be a viable approach for efficient ionization of water-soluble crude oil constituents.	Water	0-5	desumoylating isopeptidase 2	Homo sapiens	77-81
22215116-2	2012	Intrastriatal microinjection of IL-1beta induces a chronic reduction in the apparent diffusion coefficient (ADC) of tissue water, which may be indicative of metabolic failure as established by in vivo models of acute cerebral ischaemia.	Water	123-128	interleukin 1 beta	Rattus norvegicus	32-40
22201548-3	2012	The far-UV SRCD results showed that adsorption of alpha-La at oil-water interfaces created a new non-native secondary structure that was more stable to thermally induced conformational changes.	Water	66-71	lactalbumin alpha	Homo sapiens	50-58
22201548-1	2012	The conformation and structural dimensions of alpha-lactalbumin (alpha-La) both in solution and adsorbed at oil-water interfaces of emulsions were investigated using synchrotron radiation circular dichroism (SRCD) spectroscopy, front-face tryptophan fluorescence (FFTF) spectroscopy, and dual polarization interferometry (DPI).	Water	112-117	lactalbumin alpha	Homo sapiens	46-63
22201548-6	2012	The DPI study showed that adsorption of alpha-La to a hydrophobic C18-water surface caused a change in the dimensions of alpha-La from the native globule-like shape (2.5-3.7 nm) to a compact/dense layer approximately 1.1 nm thick.	Water	70-75	lactalbumin alpha	Homo sapiens	40-48
22201548-1	2012	The conformation and structural dimensions of alpha-lactalbumin (alpha-La) both in solution and adsorbed at oil-water interfaces of emulsions were investigated using synchrotron radiation circular dichroism (SRCD) spectroscopy, front-face tryptophan fluorescence (FFTF) spectroscopy, and dual polarization interferometry (DPI).	Water	112-117	lactalbumin alpha	Homo sapiens	65-73
22201548-6	2012	The DPI study showed that adsorption of alpha-La to a hydrophobic C18-water surface caused a change in the dimensions of alpha-La from the native globule-like shape (2.5-3.7 nm) to a compact/dense layer approximately 1.1 nm thick.	Water	70-75	lactalbumin alpha	Homo sapiens	121-129
22201548-11	2012	This study reports new information on the secondary and tertiary structural changes of alpha-La upon adsorption to oil-water interfaces.	Water	119-124	lactalbumin alpha	Homo sapiens	87-95
22212389-1	2012	AIM: Aquaporin-2 (AQP2) is a vasopressin-regulated water channel located in the collecting tubule and collecting duct cells of mammalian kidney.	Water	51-56	arginine vasopressin	Homo sapiens	29-40
21880554-7	2012	The immobilized catalase exhibited an excellent electrocatalytic activity towards the reduction of H(2)O(2).	Water	99-104	catalase	Homo sapiens	16-24
22346809-1	2012	In the title compound, [Co(C(16)H(19)N(2)O(2))(2)]NO(3) H(2)O, the Co(III) ion is located on an inversion center and is six-coordinated by two phenolate O atoms and four amino N atoms from two diamine ligands, forming an octa-hedral geometry.	Water	54-61	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	67-74
22346827-2	2012	The Co(II) ion is six-coordinated in a distorted octa-hedral environment, binding to two water O atoms, to the ether O atom of the bicyclo-heptane unit, to two carboxyl-ate O atoms from two different carboxyl-ate groups of the same anion and to one carboxyl-ate O atom from a symmetry-related anion.	Water	89-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22101058-3	2012	In contrast to the eutrophic and partially anoxic lake, chiA gene fragments were detectable throughout the oligotrophic water column and chiA copy numbers per ml of water were up to 15 times higher than in the eutrophic waters.	Water	120-125	chitinase acidic	Homo sapiens	56-60
22101058-3	2012	In contrast to the eutrophic and partially anoxic lake, chiA gene fragments were detectable throughout the oligotrophic water column and chiA copy numbers per ml of water were up to 15 times higher than in the eutrophic waters.	Water	165-170	chitinase acidic	Homo sapiens	137-141
22346896-2	2012	The coordination geometry of the Co(II) ion is a distorted octa-hedron with two O atoms from two coordinated water mol-ecules occupying cis positions in the equatorial plane and four O atoms from two hydrogen tartrate ions occupying the remaining positions.	Water	109-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
22056335-6	2012	Treatment of the MeOH:water (80:20) extract induced DNA fragmentation and poly(ADP-ribose) polymerase (PARP) cleavage.	Water	22-27	poly(ADP-ribose) polymerase 1	Homo sapiens	74-101
21726924-2	2012	The HERMES model-predicted Hg water and surface sediment concentrations were found to be significantly correlated (+-20%) with measured values (r(2) = 0.94, p &lt; 0.0001, n = 13) and mechanistic model predictions (LOTOX2-Hg, r(2) = 0.95, p &lt; 0.0001, n = 10).	Water	30-35	RNA binding protein, mRNA processing factor	Homo sapiens	4-10
22504763-3	2012	They reduce secretion of aldosterone and antidiuretic hormone, thus reducing salt and water reabsorption by the kidney (Groban and Butterworth, 2006).	Water	86-91	arginine vasopressin	Homo sapiens	41-61
22208532-7	2012	The CYP2A6 and CYP2E1 active sites are deeply buried, with access paths that are narrower than the radius of a water molecule.	Water	111-116	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	15-21
22056335-6	2012	Treatment of the MeOH:water (80:20) extract induced DNA fragmentation and poly(ADP-ribose) polymerase (PARP) cleavage.	Water	22-27	poly(ADP-ribose) polymerase 1	Homo sapiens	103-107
22056335-7	2012	Increased levels of Bax and cytosolic cytochrome C and decreased levels of Bcl2 were also observed in MeOH:water (80:20) treated MCF-7 cells.	Water	107-112	BCL2 associated X, apoptosis regulator	Homo sapiens	20-23
22056335-7	2012	Increased levels of Bax and cytosolic cytochrome C and decreased levels of Bcl2 were also observed in MeOH:water (80:20) treated MCF-7 cells.	Water	107-112	cytochrome c, somatic	Homo sapiens	38-50
22159297-2	2012	After four weeks of subcutaneous infusion of angiotensin II (200 ng kg(-1) min(-1)) in male SD rats, the water intake and mean artery pressure was significantly increased by 39.8% and 48.3%, respectively, as compared with the control.	Water	105-110	angiotensinogen	Rattus norvegicus	45-59
22159297-6	2012	In another group of rats, which received four weeks of lentil extract administration (1% freeze-dried MLPE in the drinking water), followed by another four weeks of extract administration plus angiotensin II infusion, the angiotensin II-induced enhancement in water intake and mean artery pressures decreased by 12.7% and 8.2%, respectively, as compared with the rats that received angiotensin II infusion alone.	Water	123-128	angiotensinogen	Rattus norvegicus	222-236
22056335-7	2012	Increased levels of Bax and cytosolic cytochrome C and decreased levels of Bcl2 were also observed in MeOH:water (80:20) treated MCF-7 cells.	Water	107-112	BCL2 apoptosis regulator	Homo sapiens	75-79
22159297-6	2012	In another group of rats, which received four weeks of lentil extract administration (1% freeze-dried MLPE in the drinking water), followed by another four weeks of extract administration plus angiotensin II infusion, the angiotensin II-induced enhancement in water intake and mean artery pressures decreased by 12.7% and 8.2%, respectively, as compared with the rats that received angiotensin II infusion alone.	Water	123-128	angiotensinogen	Rattus norvegicus	222-236
22159297-6	2012	In another group of rats, which received four weeks of lentil extract administration (1% freeze-dried MLPE in the drinking water), followed by another four weeks of extract administration plus angiotensin II infusion, the angiotensin II-induced enhancement in water intake and mean artery pressures decreased by 12.7% and 8.2%, respectively, as compared with the rats that received angiotensin II infusion alone.	Water	260-265	angiotensinogen	Rattus norvegicus	222-236
21975871-3	2012	Various types of proteins taking part in assuring effective ions and water transport in apical and basolateral membranes of the airway epithelium have been found (e.g., CFTR, ENaC, CaCC, ORCC, potassium channels, NaKATPase, aquaporins).	Water	69-74	CF transmembrane conductance regulator	Homo sapiens	169-173
22159297-6	2012	In another group of rats, which received four weeks of lentil extract administration (1% freeze-dried MLPE in the drinking water), followed by another four weeks of extract administration plus angiotensin II infusion, the angiotensin II-induced enhancement in water intake and mean artery pressures decreased by 12.7% and 8.2%, respectively, as compared with the rats that received angiotensin II infusion alone.	Water	260-265	angiotensinogen	Rattus norvegicus	222-236
22509597-5	2012	Distribution of methane in porewater is consistent with that of surface water, which decreases rapidly from B1, B2, B3 to B4 stations, from 2 212 micromol x L(-1) to 5 micromol x L(-1).	Water	31-36	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	108-124
22219322-4	2012	Local delivery of purified, exogenous DC or monocytes from bone marrow substantially increased the incidence and severity of EAU induced by adoptive transfer of activated, autoreactive CD4 or CD8 T cells that was limited to the manipulated eye.	Water	125-128	CD4 molecule	Homo sapiens	185-188
22197648-0	2012	Water"s potential role: Insights from studies of the p53 core domain.	Water	0-5	tumor protein p53	Homo sapiens	53-56
22197648-5	2012	We examined seven wild/mutant X-ray structures and observed two types of water-network hydration in three "hot hydration centers" (DNA- or small molecule- binding surfaces of the p53 core domain).	Water	73-78	tumor protein p53	Homo sapiens	179-182
22197648-9	2012	The particular environment created by different water molecules around the p53 core domain also partly explains the structural vulnerabilities of this protein.	Water	48-53	tumor protein p53	Homo sapiens	75-78
20400205-6	2012	ApoE4 mice showed better water maze learning and higher cortical apoE levels than mice expressing apoE4 in astrocytes under control of the GFAP promoter.	Water	25-30	apolipoprotein E	Homo sapiens	0-5
22096116-8	2012	In a partitioned CAP, we found that when we added Lzm-S to a partitioned space in which a semipermeable membrane prevented diffusion of Lzm-S to the carotid artery tissue, vasodilation still occurred because of diffusion of H(2)O(2).	Water	224-229	lysozyme	Homo sapiens	50-53
21822760-6	2012	Control rats consumed tap water.	Water	26-31	nuclear RNA export factor 1	Rattus norvegicus	22-25
22007837-8	2012	Leaf senescence is delayed in the SAG113 knockout mutant compared with that in the wild type, stomatal movement in the senescing leaves of SAG113 knockouts is more sensitive to ABA than that of the wild type, and the rate of water loss in senescing leaves of SAG113 knockouts is significantly reduced.	Water	225-230	PP2C protein (Clade A protein phosphatases type 2C)	Arabidopsis thaliana	139-145
22007837-8	2012	Leaf senescence is delayed in the SAG113 knockout mutant compared with that in the wild type, stomatal movement in the senescing leaves of SAG113 knockouts is more sensitive to ABA than that of the wild type, and the rate of water loss in senescing leaves of SAG113 knockouts is significantly reduced.	Water	225-230	PP2C protein (Clade A protein phosphatases type 2C)	Arabidopsis thaliana	139-145
22007837-11	2012	These findings suggest that SAG113, a negative regulator of ABA signal transduction, is specifically involved in the control of water loss during leaf senescence.	Water	128-133	PP2C protein (Clade A protein phosphatases type 2C)	Arabidopsis thaliana	28-34
22170477-2	2012	Results demonstrated that the iron complexes of both ligands are potent inhibitors of the 20S proteasome (IC(50) = 9.2 muM for [Fe(II)(OH(2))(N4Py)](2+) (3) and 4.0 muM for [Fe(II)(OH(2))(Bn-TPEN)](2+) (4)).	Water	135-141	latexin	Homo sapiens	119-122
22170477-2	2012	Results demonstrated that the iron complexes of both ligands are potent inhibitors of the 20S proteasome (IC(50) = 9.2 muM for [Fe(II)(OH(2))(N4Py)](2+) (3) and 4.0 muM for [Fe(II)(OH(2))(Bn-TPEN)](2+) (4)).	Water	135-141	latexin	Homo sapiens	165-168
22170477-2	2012	Results demonstrated that the iron complexes of both ligands are potent inhibitors of the 20S proteasome (IC(50) = 9.2 muM for [Fe(II)(OH(2))(N4Py)](2+) (3) and 4.0 muM for [Fe(II)(OH(2))(Bn-TPEN)](2+) (4)).	Water	135-140	latexin	Homo sapiens	119-122
22170477-2	2012	Results demonstrated that the iron complexes of both ligands are potent inhibitors of the 20S proteasome (IC(50) = 9.2 muM for [Fe(II)(OH(2))(N4Py)](2+) (3) and 4.0 muM for [Fe(II)(OH(2))(Bn-TPEN)](2+) (4)).	Water	135-140	latexin	Homo sapiens	165-168
22108457-6	2012	These data suggest that vasopressin can regulate an array of cellular functions well beyond its classical role in regulating water and solute transport.	Water	125-130	arginine vasopressin	Homo sapiens	24-35
22184656-10	2012	These results indicate that there is a unique regulatory chain, ABA-AtNAP-SAG113 protein phosphastase 2C, which controls stomatal movement and water loss during leaf senescence.	Water	143-148	NAC-like, activated by AP3/PI	Arabidopsis thaliana	68-73
22184656-10	2012	These results indicate that there is a unique regulatory chain, ABA-AtNAP-SAG113 protein phosphastase 2C, which controls stomatal movement and water loss during leaf senescence.	Water	143-148	PP2C protein (Clade A protein phosphatases type 2C)	Arabidopsis thaliana	74-80
22284457-0	2012	Removal of sudan dyes from water with C18-functional ultrafine magnetic silica nanoparticles.	Water	27-32	Bardet-Biedl syndrome 9	Homo sapiens	38-41
22054172-1	2012	A new water-soluble conjugated polymer containing fluorene and boron-dipyrromethene repeat units in the backbones (PBF) that exhibits red emission was synthesized and characterized.	Water	6-11	PTTG1 interacting protein	Homo sapiens	115-118
22124199-2	2012	[Cu(2)(Sal-Gly)(2)(H(2)O)(2)] crystallized in the monoclinic system in the P2(1)/c space group.	Water	19-24	cyclin dependent kinase inhibitor 1A	Homo sapiens	75-80
22155078-5	2012	The phosphohistidine is stabilized in the His432Arg structure by the guanidinium group that also restricts the access of nucleophilic water molecule to the Tdp1-DNA intermediate.	Water	134-139	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	156-160
20889219-1	2012	BACKGROUND: STK39 interacts with OXSR1 and phosphorylates the sodium-chloride co-transporter (SLC12A3), which plays a critical role in regulating the salt/water balance and blood pressure.	Water	155-160	serine/threonine kinase 39	Homo sapiens	12-17
22142421-0	2012	EPR-ENDOR characterization of (17O, 1H, 2H) water in manganese catalase and its relevance to the oxygen-evolving complex of photosystem II.	Water	44-49	catalase	Homo sapiens	63-71
22142421-4	2012	From (17)O-labeled water exchanged into the di-mu-oxo di-Mn(III,IV) coordination sphere of Mn catalase, CW Q-band ENDOR spectroscopy revealed two distinctly different (17)O signals incorporated in distinctly different time regimes.	Water	19-24	catalase	Homo sapiens	94-102
22259365-1	2012	In the title compound, [Co(C(5)H(4)NO(3))(2)(H(2)O)(2)] 2H(2)O, the coordination polyhedron around the six-coordinate Co(II) ion is formed by two equatorial 5-methyl-isoxazole-3-carboxyl-ate ligands in an N,O(3)-bidentate fashion through the isoxazole N atom and a carboxyl-ate O atom, and by two axial water ligands.	Water	303-308	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
22116833-6	2012	Detection limits of 0.05, 0.09 and 2.2 ng mL(-1) Cd(II), Pb(II) and Zn(II) were established with an accumulation time of 65 s. The method is used for the analysis of Cd(II), Pb(II) and Zn(II) in different water samples, certified reference materials, and saliva samples with satisfactory results.	Water	205-210	submaxillary gland androgen regulated protein 3B	Homo sapiens	57-63
22129570-4	2012	The combination of large extraction volume of SBSE bar, and the direct measurement power of SPI-TOFMS enable a short analysis time for VOCs in water with high sensitivity, for example the limits of detection (LODs) were in the range of 7.4-11.1 ng L(-1) for benzene, toluene, and p-xylene (BTX) within 15 min.	Water	143-148	chromogranin A	Homo sapiens	92-95
22139847-6	2012	Accordingly, the loss of p38alpha leads to ROS accumulation in response to H(2)O(2), which causes cell death and inactivation of mTOR/p70S6K signaling.	Water	75-80	mitogen-activated protein kinase 14	Homo sapiens	25-33
22139847-6	2012	Accordingly, the loss of p38alpha leads to ROS accumulation in response to H(2)O(2), which causes cell death and inactivation of mTOR/p70S6K signaling.	Water	75-80	mechanistic target of rapamycin kinase	Homo sapiens	129-133
22130356-9	2012	In addition, simvastatin raised nitric oxide synthase (NOS) activity and eNOS expression at basal condition; inhibited NOS activity and iNOS expression when treated with H(2)O(2).	Water	170-175	nitric oxide synthase 2	Rattus norvegicus	136-140
22137175-0	2012	Removal of Pb(II) from water by natural zeolitic tuff: kinetics and thermodynamics.	Water	23-28	submaxillary gland androgen regulated protein 3B	Homo sapiens	11-17
22137176-0	2012	Synthesis of composite by application of mixed Fe, Mg (hydr)oxides coatings onto bentonite--a use for the removal of Pb(II) from water.	Water	129-134	submaxillary gland androgen regulated protein 3B	Homo sapiens	117-123
22712059-0	2012	Denaturation and aggregation of lysozyme in water-ethanol solution.	Water	44-49	lysozyme	Homo sapiens	32-40
22712059-5	2012	The rheological characteristics of lysozyme-water-ethanol solution changes from Newtonian to pseudoplastic.	Water	44-49	lysozyme	Homo sapiens	35-43
22051412-0	2012	Binding interactions of water-soluble camptothecin derivatives with bovine serum albumin.	Water	24-29	albumin	Homo sapiens	75-88
22051412-1	2012	In this study, the binding interactions of the water-soluble camptothecin derivatives hydroxycamptothecin (10-HCPT), topotecan (TPT), and camptothecin quaternary salt (CPT8), to bovine serum albumin (BSA) were determined using fluorescence spectra and UV-vis spectra.	Water	47-52	albumin	Homo sapiens	185-198
22123111-1	2012	Direct electrochemical determination of arsenate (As(V)) in neutral pH waters is considered impossible due to electro-inactivity of As(V).	Water	71-77	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	50-55
22166053-0	2012	Electron transfer mechanism of cytochrome c at the oil/water interface as a biomembrane model.	Water	55-60	cytochrome c, somatic	Homo sapiens	31-43
22166053-1	2012	The electron transfer (ET) between cytochrome c (Cyt c) in water (W) and 1,1"-dimethylferrocene (DiMFc) in 1,2-dichloroethane (DCE) was studied.	Water	59-64	cytochrome c, somatic	Homo sapiens	35-47
22166053-1	2012	The electron transfer (ET) between cytochrome c (Cyt c) in water (W) and 1,1"-dimethylferrocene (DiMFc) in 1,2-dichloroethane (DCE) was studied.	Water	59-64	cytochrome c, somatic	Homo sapiens	49-54
22116423-3	2012	Aquaporin-1 (AQP1) is a water channel located mainly at the choroid plexus epithelium and plays an active role in CSF production.	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
22116423-3	2012	Aquaporin-1 (AQP1) is a water channel located mainly at the choroid plexus epithelium and plays an active role in CSF production.	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
22069195-4	2012	However, PET MPI using N-13 ammonia, rubidium-82 chloride or O-15 water is increasing in availability and usage as a result of the growing number of medical centers with new-generation PET/CT systems taking advantage of the superior imaging properties of PET over SPECT.	Water	66-71	immunoglobulin kappa variable 2-36 (pseudogene)	Homo sapiens	61-65
22001077-1	2012	The effects of centrally administered Angiotensin II (Ang II) on water and food intake in rodent models are well known.	Water	65-70	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	38-52
22001077-1	2012	The effects of centrally administered Angiotensin II (Ang II) on water and food intake in rodent models are well known.	Water	65-70	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	54-60
22001077-4	2012	Consistent with the previous reports, centrally administered Ang II rapidly stimulated water intake over the initial 1-hour period following treatment.	Water	87-92	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	61-67
22001077-5	2012	However, this acute increase was immediately followed by a marked reduction in water intake resulting in decreased cumulative water intake approximately 7h after Ang II treatment.	Water	79-84	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	162-168
22001077-5	2012	However, this acute increase was immediately followed by a marked reduction in water intake resulting in decreased cumulative water intake approximately 7h after Ang II treatment.	Water	126-131	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	162-168
22001077-6	2012	Pretreating animals with an Ang II type 1 receptor blocker, Losartan, completely antagonized the acute effect of Ang II and abolished initial water intake.	Water	142-147	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	28-34
22001077-7	2012	In contrast, application of an Ang II type 2 receptor blocker, PD123319, abrogated the prolonged inhibitory effect of Ang II on drinking behavior and partially suppressed the initial increases in water intake.	Water	196-201	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	31-37
22001077-9	2012	These experiments are the first to suggest that the stimulatory effect of central Ang II treatment on water consumption is very temporary and that it causes a sustained suppressive effect on voluntary locomotion and food intake behavior in mice.	Water	102-107	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	82-88
21937603-1	2012	Collecting duct (CD) adenylyl cyclase VI (AC6) has been implicated in arginine vasopressin (AVP)-stimulated renal water reabsorption.	Water	114-119	adenylate cyclase 6	Mus musculus	42-45
21937603-5	2012	Similarly, U(osm) was decreased in CD AC6 KO mice vs. controls after water deprivation+DDAVP administration.	Water	69-74	adenylate cyclase 6	Mus musculus	38-41
23232244-2	2012	The ATPS-MSFA method was applied for the determination of cobalt, based on the reaction between Co(II) and KSCN, which produces a metallic complex that spontaneously partitions to the top phase of the ATPS composed of poly(ethylene oxide), ammonium sulfate and water.	Water	261-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-111
22466633-3	2012	It has previously been demonstrated that endothelium-derived hydrogen peroxide (H(2)O(2)) is an EDHF in animals and humans and that endothelial nitric oxide synthase (eNOS) plays diverse roles as a nitric oxide (NO) generating system in conduit arteries and as an EDHF/H(2)O(2) generating system in microvessels.	Water	269-274	nitric oxide synthase 3	Homo sapiens	132-165
22339635-0	2012	Effect of K223E and K226E amino acid substitutions in PsbO protein of photosystem 2 on stability and functional activity of the water-oxidizing complex in Chlamydomonas reinhardtii.	Water	128-133	uncharacterized protein	Chlamydomonas reinhardtii	54-58
22339635-8	2012	In general, our study shows the importance of amino acids K223 and K226 located at the lumenal surface of PsbO protein for the activity of the water-oxidizing complex.	Water	143-148	uncharacterized protein	Chlamydomonas reinhardtii	106-110
22791150-10	2012	On the other hand, exclusion of water fraction from NDE abolished the inhibitory effect of NDE on LPS-induced COX-2 expression.	Water	32-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	110-115
23123479-1	2012	Recently, we have found that pressure-induced hemolysis is enhanced by inhibiting water transport via aquaporin-1 (AQP1), as seen in p-chloromercuribenzoate (pCMB)-treated erythrocytes.	Water	82-87	aquaporin 1 (Colton blood group)	Homo sapiens	102-113
23123479-1	2012	Recently, we have found that pressure-induced hemolysis is enhanced by inhibiting water transport via aquaporin-1 (AQP1), as seen in p-chloromercuribenzoate (pCMB)-treated erythrocytes.	Water	82-87	aquaporin 1 (Colton blood group)	Homo sapiens	115-119
22415096-1	2012	BACKGROUND/AIMS: Aquaporin-1 (AQP1) is a glycoprotein that mediates osmotic water transport, its expression has been found to correlate with tumour stage in some tumours.	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	17-28
22415096-1	2012	BACKGROUND/AIMS: Aquaporin-1 (AQP1) is a glycoprotein that mediates osmotic water transport, its expression has been found to correlate with tumour stage in some tumours.	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	30-34
23171819-1	2012	BACKGROUND: In the renal collecting duct, vasopressin regulates water permeability by a process that involves stimulation of adenylyl cyclase activity, cAMP production and subsequent translocation of water channel aquaporin-2 (AQP2) into the apical plasma membrane.	Water	64-69	arginine vasopressin	Rattus norvegicus	42-53
23171819-1	2012	BACKGROUND: In the renal collecting duct, vasopressin regulates water permeability by a process that involves stimulation of adenylyl cyclase activity, cAMP production and subsequent translocation of water channel aquaporin-2 (AQP2) into the apical plasma membrane.	Water	200-205	arginine vasopressin	Rattus norvegicus	42-53
22871279-0	2012	NHC-boranes: air- and water-tolerant co-initiators for type II photopolymerizations.	Water	22-27	high mobility group nucleosomal binding domain 4	Homo sapiens	0-3
22871279-3	2012	In particular, NHC-boranes are air-  and water-tolerant, which enhances the practicality of the photopolymerizations.	Water	41-46	high mobility group nucleosomal binding domain 4	Homo sapiens	15-18
24936343-5	2012	The dietary kakrol flesh water extract alleviated the development of skin lesions in ears accompanied by lower IgE levels and inflammatory cytokines levels in serum.	Water	25-30	immunoglobulin heavy constant epsilon	Homo sapiens	111-114
22614073-3	2012	Absence or lower abundance of calcium-binding proteins and higher abundance of prolactin-induced proteins were found in biofilm formed in the presence of sucrose or its monosaccharide constituents compared with water, the negative control group.	Water	211-216	prolactin	Homo sapiens	79-88
22135402-5	2012	Two days after surgery, mice were provided doxycycline in their drinking water to activate Akt1 transgene expression in a skeletal muscle-specific manner.	Water	73-78	thymoma viral proto-oncogene 1	Mus musculus	91-95
22474537-6	2012	It binds to its type-2 receptor (V2R) in the kidney induces a cAMP-driven cascade, which leads to the insertion of aquaporin-2 water channels into the apical membrane.	Water	127-132	arginine vasopressin receptor 2	Homo sapiens	33-36
21860657-1	2012	Salvianolic acid B (SA-B) is water-soluble component of Radix Salvia miltiorrhiza.	Water	29-34	SH3 domain binding protein 5	Homo sapiens	20-24
22649481-4	2012	We have performed the comparative crystal structure analysis of aldose reductase to understand the role of crystal water in protein-ligand interaction.	Water	115-120	aldo-keto reductase family 1 member B	Homo sapiens	64-80
22080858-8	2012	The antagonism in water and electrolyte reabsorption is dependent on the prevailing intrarenal Ang II activity.	Water	18-23	angiotensinogen	Rattus norvegicus	95-101
22297600-2	2012	The decreased cardiac output over time leads to activation of the renin-angiotensin-aldosterone system which results in vasoconstriction by influencing salt-water homeostasis.	Water	157-162	renin	Homo sapiens	66-71
22095752-3	2012	A key component is the aquaporin-0 (AQP0) water channel whose permeability is tightly regulated in healthy lenses.	Water	42-47	major intrinsic protein of lens fiber	Mus musculus	23-34
22095752-3	2012	A key component is the aquaporin-0 (AQP0) water channel whose permeability is tightly regulated in healthy lenses.	Water	42-47	major intrinsic protein of lens fiber	Mus musculus	36-40
22095752-6	2012	The additional negative charge introduced by phosphoserine 235 perturbs electrostatic interactions between AQP0 and CaM to favour water influx through the channel.	Water	130-135	major intrinsic protein of lens fiber	Mus musculus	107-111
22814191-0	2012	Change in total body water as a predictive tool for growth hormone treatment response.	Water	21-26	growth hormone 1	Homo sapiens	52-66
22915854-2	2012	In this study, we identified that the functional intensity of carboxyl groups on carbon nanotubes, which correspond to the water dispersity or hydrophilicity of carbon nanotubes, can induce conformational changes in the fibrinogen domains.	Water	123-128	fibrinogen beta chain	Homo sapiens	220-230
23097744-1	2012	Catalase is well known antioxidant enzyme which catalyses the dissociation of hydrogen peroxide directly into H(2)O and O(2).	Water	110-115	catalase	Homo sapiens	0-8
22210726-5	2012	In addition to this, the produced Cytc( +) (radical cations) can react with water, thus also regenerating Cytc.	Water	76-81	cytochrome c, somatic	Homo sapiens	34-38
22210726-5	2012	In addition to this, the produced Cytc( +) (radical cations) can react with water, thus also regenerating Cytc.	Water	76-81	cytochrome c, somatic	Homo sapiens	106-110
22919389-6	2012	The positive control solution (saturated hydroxyapatite solution) and 4500 mg/L fluoride as NaF significantly increased nanohardness D1-T by 19.9% and 24.1%, respectively, whereas 1400 mg/L fluoride as NaF, casein phosphopeptide-amorphous calcium phosphate mousse and negative control (deionised water) had no significant effect.	Water	296-301	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
22494379-6	2012	Based on the model obtained in this study, optimum H(2)O(2) dosage rate and Fe(3+) dosage were found to be 4 mg L(-1) min(-1) and 20 mg L(-1), respectively, for 51 mg L(-1) of carbofuran concentration.	Water	51-56	CD59 molecule (CD59 blood group)	Homo sapiens	118-124
23071417-12	2012	Several factors affect the bioavailability and efficacy of orally administered calcitonin, including amount of water used to take the tablet, time of day the tablet is taken, and proximity to intake of a meal.	Water	111-116	calcitonin related polypeptide alpha	Homo sapiens	79-89
22320684-1	2012	In the present study, photocatalytic Pb(II) reduction over TiO(2) and Ag/TiO(2) catalysts in the presence of formic acid was explored to eliminate Pb(II) pollution in water.	Water	167-172	submaxillary gland androgen regulated protein 3B	Homo sapiens	37-43
22320684-1	2012	In the present study, photocatalytic Pb(II) reduction over TiO(2) and Ag/TiO(2) catalysts in the presence of formic acid was explored to eliminate Pb(II) pollution in water.	Water	167-172	submaxillary gland androgen regulated protein 3B	Homo sapiens	147-153
22052024-1	2012	The arginine vasopressin receptor 2 (AVPR2) plays an important antidiuretic role in regulating water balance to maintain osmotic equilibrium.	Water	95-100	arginine vasopressin receptor 2	Homo sapiens	4-35
22052024-1	2012	The arginine vasopressin receptor 2 (AVPR2) plays an important antidiuretic role in regulating water balance to maintain osmotic equilibrium.	Water	95-100	arginine vasopressin receptor 2	Homo sapiens	37-42
23216635-9	2012	Catalase inhibited  OH generation, indicating that H(2)O(2) was generated from cells stimulated by Cr(VI) and that H(2)O(2) functioned as a precursor of  OH radical generation.	Water	51-56	catalase	Homo sapiens	0-8
22906282-7	2012	EMMPRIN inhibition significantly reduced mean brain water content and EMMPRIN mRNA and protein levels in the SAH-inhibition group,  compared with the SAH-24 group.	Water	52-57	basigin (Ok blood group)	Rattus norvegicus	0-7
22200949-2	2012	Here, we applied chromophore-assisted light inactivation (CALI) to inhibit the water permeability of AQP1, and of two AQP4 isoforms (M1 and M23), one of which (M23) forms aggregates at the cell plasma membrane.	Water	79-84	aquaporin 1 (Colton blood group)	Homo sapiens	101-105
22200949-6	2012	After KR bleaching, KR-AQP1 water permeability was reduced by up to 80% for the chimera with the shortest linker.	Water	28-33	aquaporin 1 (Colton blood group)	Homo sapiens	23-27
21541689-3	2012	Therefore, the effects of the water-soluble randomly methylated-beta-cyclodextrin (RAMEB) complex of lutein were investigated on TRPV1 and TRPA1 activation.	Water	30-35	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	139-144
21982980-4	2012	In the radial arm water maze paradigm, Pctk1, Tcf12 and Ccnd1 expressing animals all showed significant deficits in spatial working memory compared to controls.	Water	18-23	cyclin D1	Rattus norvegicus	56-61
22310126-1	2012	BACKGROUND: Aquaporin (AQP)-1 is expressed in most microvasculature endothelial cells forming water channels that play major roles in a variety of physiologic processes.	Water	94-99	aquaporin 1 (Colton blood group)	Homo sapiens	23-29
22722264-1	2012	BACKGROUND: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a disorder of water balance linked to gain-of-function mutation of arginine vasopressin receptor type 2 (AVPR2) resulting in free water reabsorption and episodes of hyponatremia.	Water	88-93	arginine vasopressin receptor 2	Homo sapiens	141-177
22722264-1	2012	BACKGROUND: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a disorder of water balance linked to gain-of-function mutation of arginine vasopressin receptor type 2 (AVPR2) resulting in free water reabsorption and episodes of hyponatremia.	Water	88-93	arginine vasopressin receptor 2	Homo sapiens	179-184
22362147-0	2012	Rapid reductive dechlorination of trichloroethene in contaminated ground water using biostimulation agent, BD-1, formulated from canola oil.	Water	73-78	defensin beta 1	Homo sapiens	107-111
25298920-2	2012	In the last decade there has been an increase in realization of the power of CYP biocatalysts for detoxification of soil and water contaminants using transgenic plants.	Water	125-130	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	77-80
21556776-5	2012	BVES, SLC3A2, and CS revealed association at least with drip loss and with several other measures of water holding capacity (WHC).	Water	101-106	blood vessel epicardial substance	Sus scrofa	0-4
21950760-4	2012	Higher protein levels of ZmPIP1;2, ZmPIP2;1/2;2, ZmPIP2;5 and ZmPIP2;6 during the day coincided with a higher water permeability of root cortex cells during the day compared with night period.	Water	110-115	aquaporin PIP2-6	Zea mays	62-70
22008632-2	2012	1,2,3-Triazole analogs were synthesized by click chemistry and labeled with fac-[ReCO3(H2O)3]Br and fac-[188ReCO3(H2O)3]+.	Water	86-91	FA complementation group C	Homo sapiens	76-79
21895698-5	2012	The mean g(H2O) was reduced by about 60% over the fumigation period, accompanied by a reduction of net CO(2) assimilation and SO(2) uptake of about 50 and 35%.	Water	11-14	sulfite oxidase	Arabidopsis thaliana	126-128
21830089-8	2012	Further analysis showed that, under drought stress conditions, ZmPIS overexpressors were found to exhibit increased membrane integrity, thereby enabling the retention of more solutes and water compared with the wild-type and the vector control transgenic lines.	Water	187-192	phosphatidylinositol synthase	Zea mays	63-68
23285044-1	2012	Aquaporin (AQP) proteins have been shown to transport water and other small molecules through biological membranes, which is crucial for plants to combat stress caused by drought.	Water	54-59	aquaporin PIP2-7-like	Nicotiana tabacum	0-9
23284772-7	2012	Areca nut water extract treatment induced p-SMAD2 and TGF-beta downstream targets in HaCaT cells but not in human gingival fibroblast cells (hGF), suggesting epithelial cells could be the source of TGF-beta in promoting OSF.	Water	10-15	transforming growth factor beta 1	Homo sapiens	54-62
23284772-7	2012	Areca nut water extract treatment induced p-SMAD2 and TGF-beta downstream targets in HaCaT cells but not in human gingival fibroblast cells (hGF), suggesting epithelial cells could be the source of TGF-beta in promoting OSF.	Water	10-15	transforming growth factor beta 1	Homo sapiens	198-206
23285044-1	2012	Aquaporin (AQP) proteins have been shown to transport water and other small molecules through biological membranes, which is crucial for plants to combat stress caused by drought.	Water	54-59	aquaporin PIP2-7-like	Nicotiana tabacum	11-14
23189124-10	2012	The removal of water molecules bridging these interactions in FPR1 can result in shrinking of the binding site during activation similarly to the shrinking observed in beta-ARs.	Water	15-20	formyl peptide receptor 1	Homo sapiens	62-66
23029502-1	2012	Previous studies reported that a subpopulation of mouse and rat trigeminal neurons express water channel aquaporin-1 (AQP1).	Water	91-96	aquaporin 1 (Colton blood group)	Homo sapiens	105-116
23189124-0	2012	The role of water in activation mechanism of human N-formyl peptide receptor 1 (FPR1) based on molecular dynamics simulations.	Water	12-17	formyl peptide receptor 1	Homo sapiens	53-78
23189124-0	2012	The role of water in activation mechanism of human N-formyl peptide receptor 1 (FPR1) based on molecular dynamics simulations.	Water	12-17	formyl peptide receptor 1	Homo sapiens	80-84
23189124-5	2012	During all MD simulation of the fMLF-FPR1 complex a water molecule transiently bridged the hydrogen bond between W254(6.48) and N108(3.35) in the middle of the receptor.	Water	52-57	formyl peptide receptor 1	Homo sapiens	37-41
23152789-10	2012	Tightly bound water molecules were predicted to be localized in the pentasaccharide binding pocket of antithrombin, but absent in thrombin.	Water	14-19	coagulation factor II, thrombin	Homo sapiens	106-114
23029160-2	2012	Low-Ca(2+) fresh water stimulated Ca(2+) influx and expressions of epithelial calcium channel (ecac), vitamin D-25-hydroxylase (cyp2r1), vitamin D receptor a (vdra), and vdrb in zebrafish.	Water	17-22	cytochrome P450, family 2, subfamily R, polypeptide 1	Danio rerio	102-126
23029160-2	2012	Low-Ca(2+) fresh water stimulated Ca(2+) influx and expressions of epithelial calcium channel (ecac), vitamin D-25-hydroxylase (cyp2r1), vitamin D receptor a (vdra), and vdrb in zebrafish.	Water	17-22	cytochrome P450, family 2, subfamily R, polypeptide 1	Danio rerio	128-134
23029160-2	2012	Low-Ca(2+) fresh water stimulated Ca(2+) influx and expressions of epithelial calcium channel (ecac), vitamin D-25-hydroxylase (cyp2r1), vitamin D receptor a (vdra), and vdrb in zebrafish.	Water	17-22	vitamin D receptor a	Danio rerio	137-157
23029160-2	2012	Low-Ca(2+) fresh water stimulated Ca(2+) influx and expressions of epithelial calcium channel (ecac), vitamin D-25-hydroxylase (cyp2r1), vitamin D receptor a (vdra), and vdrb in zebrafish.	Water	17-22	vitamin D receptor a	Danio rerio	159-163
22844468-4	2012	The purpose of this study is to investigate the effect of AbM water extracts on the regulation of IL-1beta production and activation of the NLRP3 inflammasome in human THP-1 macrophages.	Water	62-67	interleukin 1 beta	Homo sapiens	98-106
22844468-4	2012	The purpose of this study is to investigate the effect of AbM water extracts on the regulation of IL-1beta production and activation of the NLRP3 inflammasome in human THP-1 macrophages.	Water	62-67	NLR family pyrin domain containing 3	Homo sapiens	140-145
22844468-4	2012	The purpose of this study is to investigate the effect of AbM water extracts on the regulation of IL-1beta production and activation of the NLRP3 inflammasome in human THP-1 macrophages.	Water	62-67	GLI family zinc finger 2	Homo sapiens	168-173
23285080-9	2012	RESULTS: PEP-1-CAT transduction decreased MSC apoptosis rate while down-regulating MDA content and blocking LDH release as compared to the treatment with H(2)O(2) or CAT.	Water	154-159	neuronal vesicle trafficking associated 1	Rattus norvegicus	9-14
23209707-5	2012	Importantly, NAbs also recognized Abeta extracted from the water-soluble phase of human AD brain, including species that migrated on denaturing PAGE as SDS-stable dimers.	Water	59-64	amyloid beta precursor protein	Homo sapiens	34-39
22952928-2	2012	Weak associations were demonstrated between estimated GFR (eGFR) and the concentrations of several small water-soluble and protein-bound uremic solutes (MW&lt;500 Da).	Water	105-110	epidermal growth factor receptor	Homo sapiens	59-63
22808054-6	2012	Ang II simulated mitochondrial Nox4 and resulted in the abrupt production of mitochondrial superoxide (O(2) (-)) and hydrogen peroxide (H(2)O(2)).	Water	136-141	angiotensinogen	Rattus norvegicus	0-6
22761926-2	2012	In the brain, a functional secretin (SCT) and secretin receptor (SCTR) axis has recently been shown to mediate central actions of angiotensin II (ANGII), including initiation of water intake and stimulation of vasopressin (VP) expression and release.	Water	178-183	secretin receptor	Mus musculus	46-63
22761926-2	2012	In the brain, a functional secretin (SCT) and secretin receptor (SCTR) axis has recently been shown to mediate central actions of angiotensin II (ANGII), including initiation of water intake and stimulation of vasopressin (VP) expression and release.	Water	178-183	secretin receptor	Mus musculus	65-69
22761926-2	2012	In the brain, a functional secretin (SCT) and secretin receptor (SCTR) axis has recently been shown to mediate central actions of angiotensin II (ANGII), including initiation of water intake and stimulation of vasopressin (VP) expression and release.	Water	178-183	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	130-144
22761926-2	2012	In the brain, a functional secretin (SCT) and secretin receptor (SCTR) axis has recently been shown to mediate central actions of angiotensin II (ANGII), including initiation of water intake and stimulation of vasopressin (VP) expression and release.	Water	178-183	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	146-151
22949256-1	2012	Peroxidase from soybean seed coats catalyzes the oxidation and polymerization of aromatic compounds in the presence of H(2)O(2).	Water	119-124	peroxidase	Glycine max	0-10
22403603-1	2012	The kidney maintains water homeostasis by modulating aquaporin 2 (AQP2) on the plasma membrane of collecting duct principal cells in response to vasopressin (VP).	Water	21-26	vasopressin	Sus scrofa	145-156
22888962-8	2012	Apelin level was positively correlated with ejection fraction and negatively with total body water (TBW), intracellular and extracellular water, lean tissue mass, and left atrium diameter.	Water	93-98	apelin	Homo sapiens	0-6
22888962-8	2012	Apelin level was positively correlated with ejection fraction and negatively with total body water (TBW), intracellular and extracellular water, lean tissue mass, and left atrium diameter.	Water	138-143	apelin	Homo sapiens	0-6
22685550-5	2012	IFN-alpha and IL-4 were effectively expressed in the eyes from three weeks to three months following subretinal injection of AAV2 vectors either alone or following combined administration and significantly attenuated EAU activity clinically and histopathologically.	Water	217-220	interferon alpha 1	Homo sapiens	0-9
22685550-5	2012	IFN-alpha and IL-4 were effectively expressed in the eyes from three weeks to three months following subretinal injection of AAV2 vectors either alone or following combined administration and significantly attenuated EAU activity clinically and histopathologically.	Water	217-220	interleukin 4	Homo sapiens	14-18
22662182-1	2012	Calmodulin (CaM) directly interacts with the aquaporin 0 (AQP0) C-terminus in a calcium dependent manner to regulate the water permeability of AQP0.	Water	121-126	calmodulin 1	Homo sapiens	0-10
22662182-1	2012	Calmodulin (CaM) directly interacts with the aquaporin 0 (AQP0) C-terminus in a calcium dependent manner to regulate the water permeability of AQP0.	Water	121-126	calmodulin 1	Homo sapiens	12-15
22662182-1	2012	Calmodulin (CaM) directly interacts with the aquaporin 0 (AQP0) C-terminus in a calcium dependent manner to regulate the water permeability of AQP0.	Water	121-126	major intrinsic protein of lens fiber	Homo sapiens	45-56
22662182-1	2012	Calmodulin (CaM) directly interacts with the aquaporin 0 (AQP0) C-terminus in a calcium dependent manner to regulate the water permeability of AQP0.	Water	121-126	major intrinsic protein of lens fiber	Homo sapiens	58-62
22662182-1	2012	Calmodulin (CaM) directly interacts with the aquaporin 0 (AQP0) C-terminus in a calcium dependent manner to regulate the water permeability of AQP0.	Water	121-126	major intrinsic protein of lens fiber	Homo sapiens	143-147
22662182-13	2012	Due to lack of the modulation of the Ca2+-calmodulin complex, the water permeability of AQP0 was subsequently augmented, which might lead to the development of this cataract.	Water	66-71	calmodulin 1	Homo sapiens	42-52
22662182-13	2012	Due to lack of the modulation of the Ca2+-calmodulin complex, the water permeability of AQP0 was subsequently augmented, which might lead to the development of this cataract.	Water	66-71	major intrinsic protein of lens fiber	Homo sapiens	88-92
22470485-3	2012	The present study aims at determining whether ocular application of a water soluble B(1)R antagonist could reverse diabetes-induced retinal inflammation and oxidative stress.	Water	70-75	bradykinin receptor B1	Rattus norvegicus	84-89
22389698-5	2012	The computational analyses, which were confirmed in water and using different CBAH mutants, revealed the existence of a chair-like transition state, which might be one of the specific features of the catalytic cycle of Ntn-hydrolases.	Water	52-57	neurotensin	Homo sapiens	219-222
22238646-2	2012	In this study, we have used ORLL-NIH001, a small synthetic compound that inhibits transcriptional activity of STAT3, to ameliorate EAU, an animal model of human posterior uveitis.	Water	131-134	signal transducer and activator of transcription 3	Homo sapiens	110-115
22567890-5	2012	A genetic control of the s 1 LOG and s2LOG activity at an optimal water supply level was associated with chromosomes 1A, 1D, 3A, 5A, 5B, and 5D, while under the conditions of the modeled soil drought, it was associated with chromosomes 1B and 1D.	Water	66-71	LOC543232	Triticum aestivum	29-32
22645471-5	2012	According to the Council Directive75/440/EEC, the evaluation of the ecostatus, with slight deviation of individual parameters at Pancevo, corresponds to A1 category of the surface water quality intended for the abstraction of drinking water supplies in member states.	Water	180-185	Ectrodactyly, ectodermal dysplasia, cleft lip/palate, 1	Homo sapiens	41-44
22147224-1	2012	Myrcianthes ferreyrae is an endemic, endangered species, with a small number of individuals located only in hyperarid, fog-oases known as lomas along the Peruvian desert in southern Peru, where fog is the main source of water.	Water	220-225	zinc finger protein, FOG family member 1	Homo sapiens	194-197
22129572-7	2011	Detection limits in ultrapure water were between 3.0 and 110 ngL(-1) for ibuprofen and ketoprofen, respectively.	Water	30-35	leucine rich repeat containing 4C	Homo sapiens	61-67
22225188-0	2011	Preferential solvation of lysozyme in water/ethanol mixtures.	Water	38-43	lysozyme	Homo sapiens	26-34
22225188-1	2011	We provide a quantitative description of the solvation properties of lysozyme in water/ethanol mixtures, which has been obtained by a simultaneous analysis of small-angle neutron scattering and differential scanning calorimetry experiments.	Water	81-86	lysozyme	Homo sapiens	69-77
22025059-0	2011	Molecular geometries of H2S   ICF3 and H2O   ICF3 characterised by broadband rotational spectroscopy.	Water	39-42	cell division cycle associated 7	Homo sapiens	45-49
21952651-7	2011	In the presence of H(2)O(2), the ECL intensity increased with the increase of AFP, which indicated that an immunosensor for AFP was constructed.	Water	19-24	alpha fetoprotein	Homo sapiens	78-81
21952651-7	2011	In the presence of H(2)O(2), the ECL intensity increased with the increase of AFP, which indicated that an immunosensor for AFP was constructed.	Water	19-24	alpha fetoprotein	Homo sapiens	124-127
22860163-1	2011	The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-beta and tau peptide aggregation is presented.	Water	19-24	amyloid beta precursor protein	Homo sapiens	135-147
22050123-1	2011	A one-pot synthesis of extremely stable, water-soluble Cu quantum clusters (QCs) capped with a model protein, bovine serum albumin (BSA), is reported.	Water	41-46	albumin	Homo sapiens	117-130
22077332-5	2011	Energetic analysis of Abeta adsorption on the SAMs reveals that Abeta adsorption on the SAMs is a net outcome of different competitions between dominant hydrophobic Abeta-CH(3)-SAM interactions and weak CH(3)-SAM-water interactions, between dominant electrostatic Abeta-COOH-SAM interactions and strong COOH-SAM-water interactions, and between comparable hydrophobic and electrostatic Abeta-OH-SAM interactions and strong OH-SAM-water interactions.	Water	213-218	amyloid beta precursor protein	Homo sapiens	64-69
22077332-5	2011	Energetic analysis of Abeta adsorption on the SAMs reveals that Abeta adsorption on the SAMs is a net outcome of different competitions between dominant hydrophobic Abeta-CH(3)-SAM interactions and weak CH(3)-SAM-water interactions, between dominant electrostatic Abeta-COOH-SAM interactions and strong COOH-SAM-water interactions, and between comparable hydrophobic and electrostatic Abeta-OH-SAM interactions and strong OH-SAM-water interactions.	Water	312-317	amyloid beta precursor protein	Homo sapiens	64-69
22077332-5	2011	Energetic analysis of Abeta adsorption on the SAMs reveals that Abeta adsorption on the SAMs is a net outcome of different competitions between dominant hydrophobic Abeta-CH(3)-SAM interactions and weak CH(3)-SAM-water interactions, between dominant electrostatic Abeta-COOH-SAM interactions and strong COOH-SAM-water interactions, and between comparable hydrophobic and electrostatic Abeta-OH-SAM interactions and strong OH-SAM-water interactions.	Water	312-317	amyloid beta precursor protein	Homo sapiens	64-69
22077332-5	2011	Energetic analysis of Abeta adsorption on the SAMs reveals that Abeta adsorption on the SAMs is a net outcome of different competitions between dominant hydrophobic Abeta-CH(3)-SAM interactions and weak CH(3)-SAM-water interactions, between dominant electrostatic Abeta-COOH-SAM interactions and strong COOH-SAM-water interactions, and between comparable hydrophobic and electrostatic Abeta-OH-SAM interactions and strong OH-SAM-water interactions.	Water	312-317	amyloid beta precursor protein	Homo sapiens	64-69
22077332-5	2011	Energetic analysis of Abeta adsorption on the SAMs reveals that Abeta adsorption on the SAMs is a net outcome of different competitions between dominant hydrophobic Abeta-CH(3)-SAM interactions and weak CH(3)-SAM-water interactions, between dominant electrostatic Abeta-COOH-SAM interactions and strong COOH-SAM-water interactions, and between comparable hydrophobic and electrostatic Abeta-OH-SAM interactions and strong OH-SAM-water interactions.	Water	312-317	amyloid beta precursor protein	Homo sapiens	64-69
22077332-5	2011	Energetic analysis of Abeta adsorption on the SAMs reveals that Abeta adsorption on the SAMs is a net outcome of different competitions between dominant hydrophobic Abeta-CH(3)-SAM interactions and weak CH(3)-SAM-water interactions, between dominant electrostatic Abeta-COOH-SAM interactions and strong COOH-SAM-water interactions, and between comparable hydrophobic and electrostatic Abeta-OH-SAM interactions and strong OH-SAM-water interactions.	Water	312-317	amyloid beta precursor protein	Homo sapiens	64-69
22077332-5	2011	Energetic analysis of Abeta adsorption on the SAMs reveals that Abeta adsorption on the SAMs is a net outcome of different competitions between dominant hydrophobic Abeta-CH(3)-SAM interactions and weak CH(3)-SAM-water interactions, between dominant electrostatic Abeta-COOH-SAM interactions and strong COOH-SAM-water interactions, and between comparable hydrophobic and electrostatic Abeta-OH-SAM interactions and strong OH-SAM-water interactions.	Water	312-317	amyloid beta precursor protein	Homo sapiens	64-69
22143774-5	2011	Claudin-2, a molecule responsible for the Na(+) and H(2)O permeability of the TJs, is also present at the cilium, as it colocalizes and coprecipitates with acetylated alpha-tubulin.	Water	52-57	claudin 2	Canis lupus familiaris	0-9
22077332-5	2011	Energetic analysis of Abeta adsorption on the SAMs reveals that Abeta adsorption on the SAMs is a net outcome of different competitions between dominant hydrophobic Abeta-CH(3)-SAM interactions and weak CH(3)-SAM-water interactions, between dominant electrostatic Abeta-COOH-SAM interactions and strong COOH-SAM-water interactions, and between comparable hydrophobic and electrostatic Abeta-OH-SAM interactions and strong OH-SAM-water interactions.	Water	213-218	amyloid beta precursor protein	Homo sapiens	64-69
22077332-5	2011	Energetic analysis of Abeta adsorption on the SAMs reveals that Abeta adsorption on the SAMs is a net outcome of different competitions between dominant hydrophobic Abeta-CH(3)-SAM interactions and weak CH(3)-SAM-water interactions, between dominant electrostatic Abeta-COOH-SAM interactions and strong COOH-SAM-water interactions, and between comparable hydrophobic and electrostatic Abeta-OH-SAM interactions and strong OH-SAM-water interactions.	Water	213-218	amyloid beta precursor protein	Homo sapiens	64-69
22070391-4	2011	Bovine serum albumin (BSA)-water partition coefficients (K(BSA/w)) were measured for 83 structurally diverse neutral organic chemicals in consistent experimental conditions.	Water	27-32	albumin	Homo sapiens	7-20
22021053-3	2011	These bioinspired fibers are inexpensive and durable, which makes it possible to collect water from fog in a similar manner to a spider"s web.	Water	89-94	zinc finger protein, FOG family member 1	Homo sapiens	100-103
25585566-5	2011	The measured frequency shift during the calcium adsorptions was found to be strongly dependent on the surface concentration of the immobilized calmodulin, which indicates that the measured signal is significantly influenced by the amount of water inside the calmodulin layer.	Water	241-246	calmodulin 1	Homo sapiens	143-153
22001535-4	2011	Water was used as the solvent to solubilize lysozyme and thus no organic residual was detected.	Water	0-5	lysozyme	Homo sapiens	44-52
22018869-7	2011	We further isolated an As(V)-reducing bacterium native to aquifer sediments which showed that the direct enzymatic reduction of As(V) to the potentially more-soluble As(III) in pore water is possible in this aquifer.	Water	182-187	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-28
22018869-7	2011	We further isolated an As(V)-reducing bacterium native to aquifer sediments which showed that the direct enzymatic reduction of As(V) to the potentially more-soluble As(III) in pore water is possible in this aquifer.	Water	182-187	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	128-133
25585566-5	2011	The measured frequency shift during the calcium adsorptions was found to be strongly dependent on the surface concentration of the immobilized calmodulin, which indicates that the measured signal is significantly influenced by the amount of water inside the calmodulin layer.	Water	241-246	calmodulin 1	Homo sapiens	258-268
21907314-5	2011	Proteins in milk can be present in casein micelles, in the serum (the water soluble fraction) or in fat globules.	Water	70-75	Weaning weight-maternal milk	Bos taurus	12-16
22007676-7	2011	These results have led to a structurally simpler, synthetically more accessible, and water-soluble analogue possessing strong TLR2-agonistic activities in human blood.	Water	85-90	toll like receptor 2	Homo sapiens	126-130
21771249-7	2011	Additionally, our results indicate that both TNF-alpha and hydrogen peroxide (H(2) O(2) ) are potent inducers of Mstn and require NF-kappaB signaling for Mstn induction.	Water	78-84	myostatin	Homo sapiens	113-117
22093352-2	2011	Polyvinyl alcohol as an amphiphilic surfactant rendered the powders dispersible in water with regular round shape (10-20 mum).	Water	83-88	latexin	Homo sapiens	121-124
21994916-4	2011	Under the optimum SPE conditions, all target analytes in 50 mL environmental water samples can be completely extracted by 1.5 mg Nylon 6 nanofibers mat at flow rate of 3.0 mL min(-1) and easily eluted by passage of 500 muL mobile phase.	Water	77-82	CD59 molecule (CD59 blood group)	Homo sapiens	175-181
22042871-5	2011	Animals injected with AAV2/1-FGF2 at a pre- or postsymptomatic stage show significantly improved spatial learning in the radial arm water maze test.	Water	132-137	fibroblast growth factor 2	Homo sapiens	29-33
22199511-2	2011	The Co(II) atom is located on an inversion centre and displays a distorted octa-hedral coordination geometry defined by four O atoms of two 3-aza-niumyl-1-hy-droxy-propyl-idene-1,1-bis-phospho-nato ligands in the equatorial plane and two water mol-ecules located in axial positions.	Water	238-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22199572-1	2011	In the title compound, [CoNa(2)(C(7)H(3)NO(4))(2)(H(2)O)(2)](n), the Co(II) atom is coordinated by two pyridine N atoms and four carboxyl-ate O atoms from two doubly deprotonated pyridine-2,6-dicarboxyl-ate ligands in a distorted octa-hedral geometry.	Water	50-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
21771249-7	2011	Additionally, our results indicate that both TNF-alpha and hydrogen peroxide (H(2) O(2) ) are potent inducers of Mstn and require NF-kappaB signaling for Mstn induction.	Water	78-84	nuclear factor kappa B subunit 1	Homo sapiens	130-139
21771249-7	2011	Additionally, our results indicate that both TNF-alpha and hydrogen peroxide (H(2) O(2) ) are potent inducers of Mstn and require NF-kappaB signaling for Mstn induction.	Water	78-84	myostatin	Homo sapiens	154-158
21790668-7	2011	In addition, cytochrome p450IIE1 (CYP2E1) mRNA, protein expression/activity, and intrahepatic oxidative stress were significantly increased in alcohol-consuming P rat livers versus water only.	Water	181-186	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	34-40
22146965-3	2011	The organic leaf extract was able to restore superoxide dismutase (kidney and liver) and catalase (heart) activities, which were modified by the treatment with H(2)O(2).	Water	160-165	catalase	Rattus norvegicus	89-97
21926263-4	2011	Exposure of either 16HBE14o- or MTE cells to H(2)O(2) resulted in significant loss of transepithelial electrical resistance and increased permeability to fluorescein isothiocyanate-dextran (4 kDa), and this was attenuated significantly after prior activation of HIF-1 by preexposure to hypoxia (2% O(2); 6 h) or the hypoxia mimics CoCl(2) or dimethyloxalylglycine (DMOG).	Water	45-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	262-267
21875624-8	2011	Activation of caspases-4/-12 was decreased by the calcium chelator BAPTA-AM, and by inhibitors of calpain and caspase-7, confirming the roles of calcium, calpain and caspase-7 in activation of ER-mediated apoptosis by H(2)O(2).	Water	218-223	caspase 4	Homo sapiens	14-22
21994426-1	2011	OBJECTIVE: Water intake alters vasopressin secretion.	Water	11-16	arginine vasopressin	Homo sapiens	31-42
21945376-2	2011	By gradually decreasing the ambient RH of the insulin crystal, the content of the hydration water in the crystal was quantitatively controlled.	Water	92-97	insulin	Homo sapiens	46-53
21975647-0	2011	Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake.	Water	51-56	glucagon	Homo sapiens	0-23
21975647-5	2011	The present experiments were designed to provide greater temporal resolution and site specificity for the effect of GLP-1 and the long-acting GLP-1R agonists, exendin-4 and liraglutide, on unstimulated water intake when food was and was not available.	Water	202-207	glucagon	Homo sapiens	116-121
22021246-4	2011	METHODS AND RESULTS: Fifteen carriers of an MYBPC3 mutation underwent [(15)O]water positron emission tomography (PET) to assess myocardial blood flow (MBF).	Water	77-82	myosin binding protein C3	Homo sapiens	44-50
22027101-2	2011	We describe a novel class of small water-soluble Abeta binding peptidomimetics based on two hydrophobic Ala-Val and Val-Leu dipeptides linked to a D-glucopyranosyl scaffold through aminoalkyl and carboxyethyl links in C1 and C6 positions.	Water	35-40	amyloid beta precursor protein	Homo sapiens	49-54
22103869-6	2011	One of these vaptans - tolvaptan - is an oral vasopressin V2-receptor antagonist that induces free water excretion without increasing sodium excretion.	Water	99-104	arginine vasopressin receptor 2	Homo sapiens	46-69
21865318-9	2011	These data implicate AQP3 as a novel determinant in macrophage immune function by a cellular mechanism involving facilitated water and glycerol transport, and consequent phagocytic and migration activity.	Water	125-130	aquaporin 3	Mus musculus	21-25
21865318-7	2011	Water and glycerol permeabilities in mRPMs from AQP3(-/-) mice were reduced compared to mRPMs from AQP3(+/+) mice.	Water	0-5	aquaporin 3	Mus musculus	48-52
23724232-2	2011	We investigated whether prolonged restriction and voluntary exposure of previously sensitized (immunized) mice to ovalbumin (OVA) in the drinking water would alter subsequent responses to bronchial (aerosol) challenge with OVA.	Water	146-151	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	114-123
21907305-5	2011	Quantitative real-time PCR showed the rapid increase of Ostf1 in gill after transfer of medaka from fresh water to 50% seawater; particularly Ostf1b whose mRNA expression increased to 4 folds at 0.5h and reached to 10 folds at 6h after the transfer.	Water	106-111	osteoclast-stimulating factor 1	Oryzias latipes	56-61
21911079-4	2011	SOD catalyzes the dismutation of O(2)(-) to H(2)O(2), and GPx catalyzes the reduction of H(2)O(2) and other harmful peroxides by glutathione (GSH).	Water	44-49	superoxide dismutase 1	Homo sapiens	0-3
21911079-4	2011	SOD catalyzes the dismutation of O(2)(-) to H(2)O(2), and GPx catalyzes the reduction of H(2)O(2) and other harmful peroxides by glutathione (GSH).	Water	89-94	superoxide dismutase 1	Homo sapiens	0-3
23724232-2	2011	We investigated whether prolonged restriction and voluntary exposure of previously sensitized (immunized) mice to ovalbumin (OVA) in the drinking water would alter subsequent responses to bronchial (aerosol) challenge with OVA.	Water	146-151	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	125-128
22066538-9	2011	For H1 peptide which exhibits large solvent exposure of the hydrophobic residues, the GROMOS 43A1 force field with the SPC water model can provide more accurate results.	Water	123-128	proline rich protein gene cluster	Homo sapiens	119-122
22048425-4	2011	A hot tub recirculating water without a filter was used for this research.	Water	24-29	TUB bipartite transcription factor	Homo sapiens	6-9
22066532-11	2011	Possibly, the aliphatic ligand containing carboxyl, amide or hydrophilic groups with flexible structure may be implicated for hIMPDH-II inhibitor design using the conserved water mimic drug design protocol.	Water	173-178	inosine monophosphate dehydrogenase 2	Homo sapiens	126-135
21824991-1	2011	The renin-angiotensin system is well known as a systemic endocrine pathway that regulates blood pressure and salt-water metabolism.	Water	114-119	renin	Homo sapiens	4-9
22123359-3	2011	Vasopressin antagonists are effective in removing large amounts of water, but not salt, in HF.	Water	67-72	arginine vasopressin	Homo sapiens	0-11
21907808-6	2011	The structure reveals a conserved glutamate binding mode, characteristic for iGluRs, and a water molecule network in the glutamate binding site similar to that seen in GluK1.	Water	91-96	glutamate ionotropic receptor kainate type subunit 1	Homo sapiens	168-173
27502633-0	2011	Interaction of Water-Soluble CdTe Quantum Dots with Bovine Serum Albumin.	Water	15-20	albumin	Homo sapiens	59-72
22304097-3	2011	Considering recent evidence demonstrating that the contact angle of water on a graphitic plane is much higher than what was previously reported, we estimate the oxygen-carbon interaction for the recent SPC/Fw water model.	Water	68-73	proline rich protein gene cluster	Homo sapiens	202-205
21940485-1	2011	The water channel aquaporin-1 (AQP1) is the molecular counterpart of the ultrasmall pore that mediates free water transport during peritoneal dialysis (PD).	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	31-35
21940485-1	2011	The water channel aquaporin-1 (AQP1) is the molecular counterpart of the ultrasmall pore that mediates free water transport during peritoneal dialysis (PD).	Water	108-113	aquaporin 1 (Colton blood group)	Homo sapiens	31-35
21907406-9	2011	It may be presumed that the orexins can play a physiological role in the regulation of the water metabolism by reducing the effect of increased vasopressin release caused by monoaminergic compounds.	Water	91-96	arginine vasopressin	Rattus norvegicus	144-155
22018417-11	2011	CONCLUSION: AQP9 water permeability seems to be independent of its molecular expression, strongly suggesting that AQP9 might not have a key role in water transport in human placenta.	Water	17-22	aquaporin 9	Homo sapiens	12-16
22304097-3	2011	Considering recent evidence demonstrating that the contact angle of water on a graphitic plane is much higher than what was previously reported, we estimate the oxygen-carbon interaction for the recent SPC/Fw water model.	Water	209-214	proline rich protein gene cluster	Homo sapiens	202-205
21925574-6	2011	We conclude that baclofen may produce a non-specific blockade of the inhibitory mechanisms of LPBN (deactivation of LPBN inhibitory mechanisms) and this blockade is facilitated by angiotensin II acting on AT(1) receptors in the LPBN, which drives rats to ingest large amounts of water and hypertonic NaCl independent if rats are fluid depleted or normohydrated.	Water	279-284	angiotensinogen	Rattus norvegicus	180-194
21952227-3	2011	The method is based on considering only a short-range part of a total realistic potential (such as SPC/E or TIPxP) which determines the structure of water (and fluids in general).	Water	149-154	proline rich protein gene cluster	Homo sapiens	99-102
21975508-1	2011	The complexes of C-reactive protein (CRP) with its polymerizable phosphocholine ligands adsorbed at the styrene-water interface were polymerized.	Water	112-117	C-reactive protein	Homo sapiens	17-35
21893164-2	2011	A question that remains is if the activity of facilitatory mechanisms, like angiotensin II, is necessary for sodium and water intake induced by muscimol (GABA(A) receptor agonist) injected into the LPBN.	Water	120-125	angiotensinogen	Rattus norvegicus	76-90
22035316-0	2011	Induced self-assembly and Forster resonance energy transfer studies of alkynylplatinum(II) terpyridine complex through interaction with water-soluble poly(phenylene ethynylene sulfonate) and the proof-of-principle demonstration of this two-component ensemble for selective label-free detection of human serum albumin.	Water	136-141	albumin	Homo sapiens	303-316
21975508-1	2011	The complexes of C-reactive protein (CRP) with its polymerizable phosphocholine ligands adsorbed at the styrene-water interface were polymerized.	Water	112-117	C-reactive protein	Homo sapiens	37-40
22101434-6	2011	Lyn activation in neutrophils is dependent on wound-derived H(2)O(2) after tissue injury, and inhibition of Lyn attenuates neutrophil wound recruitment.	Water	60-65	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
21864635-1	2011	Bromate (BrO(3)(-)) is a drinking water disinfection by-product (DBP) that induces renal cell death via DNA damage-dependent and -independent mechanisms.	Water	34-39	D-box binding PAR bZIP transcription factor	Homo sapiens	65-68
21855891-7	2011	We reported in this study that the binding, orientation and persistence of sPLA2 at the lipid-water interface is probably governed by the electrostatic and hydrophobic forces operative at this surface.	Water	94-99	phospholipase A2 group X	Homo sapiens	75-80
21989727-7	2011	RESULTS: IRBPp-specific CD25+CD4+ T cells from spleens of EAU-recovered wild-type mice express a Treg cell phenotype of FoxP3 and TGF-beta compared with the effector T-cell phenotype of IFN-gamma and IL-17 production in EAU-recovered MC5r-/- mice.	Water	58-61	interferon gamma	Mus musculus	186-195
22090488-7	2011	Our findings identify DCAR-1 as the first seven-transmembrane receptor required for avoidance of a water-soluble repellent, DHCA, in C. elegans.	Water	99-104	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	22-28
21889841-1	2011	New nano hybrid material (ZrO(2)/B(2)O(3)) was synthesized and applied as a sorbent for the separation and/or preconcentration of Co(II), Cu(II) and Cd(II) in water and tea leaves prior to their determination by flame atomic absorption spectrometry.	Water	159-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
21615722-4	2011	We hypothesized that a decrease in nNOS-derived H(2)O(2) contributes to the impaired vasodilatation in apolipoprotein E-deficient mice (ApoE(-/-)).	Water	48-53	apolipoprotein E	Mus musculus	136-140
22020074-2	2011	Water permeates through AQP0 much more slowly than other aquaporin family members, and other compounds, such as glycerol, also permeate AQP0.	Water	0-5	major intrinsic protein of lens fiber	Mus musculus	24-28
22020074-9	2011	These data suggest that AA as well as water permeates AQP0.	Water	38-43	major intrinsic protein of lens fiber	Mus musculus	54-58
21842881-5	2011	Starting from a molecular dynamics simulation of the 266 residue protein 6PGL in explicit water, we construct virtual (15)N R(1), R(2), and NOE relaxation rates at two different magnetic fields, including artificial noise, and test how far the parameters obtained from a fit of the model to the virtual experimental data coincide with those obtained from an analysis of the MD time correlation functions that have been used to construct these data.	Water	90-95	6-phosphogluconolactonase	Homo sapiens	73-77
22219767-1	2011	The Co(II) atom in the title salt, [Co(H(2)O)(6)](C(13)H(10)NO(3))(2) 2H(2)O, lies on a center of inversion in an octa-hedron of water mol-ecules.	Water	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22219767-1	2011	The Co(II) atom in the title salt, [Co(H(2)O)(6)](C(13)H(10)NO(3))(2) 2H(2)O, lies on a center of inversion in an octa-hedron of water mol-ecules.	Water	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22006981-7	2011	We tested the hypothesis that MLC1 mutations cause a defect in ion currents involved in water and ion homeostasis, resulting in cerebral white matter oedema.	Water	88-93	modulator of VRAC current 1	Homo sapiens	30-34
22107799-7	2011	In particular, CaSR reduces passive and active calcium reabsorption in distal tubules, increases phosphate reabsorption in proximal tubules and stimulates proton and water excretion in collecting ducts.	Water	166-171	calcium sensing receptor	Homo sapiens	15-19
22107799-11	2011	Stone formation may be favored by an altered CaSR expression in kidney medulla involving the normal balance among calcium, phosphate, protons and water excretion.	Water	146-151	calcium sensing receptor	Homo sapiens	45-49
22070307-1	2011	We have investigated the pressure-induced spectral changes and the proton exchange reactions of D(2)-H(2)O mixtures to 64 GPa using micro-Raman spectroscopy.	Water	101-106	glycophorin A (MNS blood group)	Homo sapiens	122-125
22070307-8	2011	Based on the time-dependent spectral changes, we obtained the proton exchange rates of k ~ 0.085 h(-1) at 0.2 GPa in fluid D(2) and water mixtures, k ~ 0.03 h(-1) and 0.003 h(-1) at 2 GPa and 4 GPa, respectively, in fluid D(2)-ice mixtures, and k ~ 10(-3) h(-1) at 8 GPa in solid D(2) and ice mixtures.	Water	132-137	glycophorin A (MNS blood group)	Homo sapiens	110-113
22070307-8	2011	Based on the time-dependent spectral changes, we obtained the proton exchange rates of k ~ 0.085 h(-1) at 0.2 GPa in fluid D(2) and water mixtures, k ~ 0.03 h(-1) and 0.003 h(-1) at 2 GPa and 4 GPa, respectively, in fluid D(2)-ice mixtures, and k ~ 10(-3) h(-1) at 8 GPa in solid D(2) and ice mixtures.	Water	132-137	glycophorin A (MNS blood group)	Homo sapiens	184-187
22070307-8	2011	Based on the time-dependent spectral changes, we obtained the proton exchange rates of k ~ 0.085 h(-1) at 0.2 GPa in fluid D(2) and water mixtures, k ~ 0.03 h(-1) and 0.003 h(-1) at 2 GPa and 4 GPa, respectively, in fluid D(2)-ice mixtures, and k ~ 10(-3) h(-1) at 8 GPa in solid D(2) and ice mixtures.	Water	132-137	glycophorin A (MNS blood group)	Homo sapiens	184-187
22070307-8	2011	Based on the time-dependent spectral changes, we obtained the proton exchange rates of k ~ 0.085 h(-1) at 0.2 GPa in fluid D(2) and water mixtures, k ~ 0.03 h(-1) and 0.003 h(-1) at 2 GPa and 4 GPa, respectively, in fluid D(2)-ice mixtures, and k ~ 10(-3) h(-1) at 8 GPa in solid D(2) and ice mixtures.	Water	132-137	glycophorin A (MNS blood group)	Homo sapiens	184-187
21615722-9	2011	Inhibition of nNOS with L-Arg(NO2) -L-Dbu, knockdown of nNOS and catalase, which decomposes H(2)O(2) into oxygen and water, decreased ACh-induced relaxation by half, produced a small diminution of NO production and abolished H(2)O(2) in wild-type animals, but had no effect in ApoE(-/-) mice.	Water	117-122	catalase	Mus musculus	65-73
21872331-2	2011	Levels of total HCHs ( HCH) and total DDTs ( DDT) in water detected by GC-ECD ranged from 0.85 to 12.77 ng L-1 and from 3.54 to 33.59 ng L-1, respectively.	Water	53-58	immunoglobulin kappa variable 1-16	Homo sapiens	107-110
21199326-5	2011	Characterization of the cognitive function of p60TRP transgenic mice using the radial arm water maze test demonstrated that p60TRP improved memory and learning abilities.	Water	90-95	basic helix-loop-helix family member B9	Rattus norvegicus	46-52
22113397-3	2011	This finding supports the two-state picture derived from the analysis of the inherent dynamics of bulk SPC/E water.	Water	109-114	proline rich protein gene cluster	Homo sapiens	103-106
21750082-4	2011	We exposed normal cells and K562 cells with silenced peroxiredoxin-2 to H(2)O(2) and generated a recombinant peroxiredoxin-2 for kinetic measurements in the presence of H(2)O(2) or hemin.	Water	72-77	peroxiredoxin 2	Homo sapiens	53-68
21704065-1	2011	NMR structure of biosynthetic engineered A22G-B31K-B32R human insulin monomer in water/acetonitrile solution.	Water	81-86	insulin	Homo sapiens	62-69
22320082-1	2011	Two simple and sensitive spectrofluorimetric methods were developed for determination of three water-soluble vitamins (B1, B2, and B6) in mixtures in the presence of cyanocobalamin.	Water	95-100	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	119-133
22320082-5	2011	The three water-soluble vitamins (B1, B2, and B6) were determined spectrofluorimetrically in binary, ternary, and quaternary mixtures in the presence of cyanocobalamin.	Water	10-15	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	34-48
20549630-0	2011	Neural tube defects in mice exposed to tap water.	Water	43-48	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	39-42
20549630-10	2011	When F2-DDI mice were provided tap water from three different urban areas prior to breeding, their offspring again developed NTDs.	Water	35-40	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	31-34
20549630-11	2011	Increased length of exposure to tap water significantly increased the incidence of NTDs.	Water	36-41	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	32-35
20549630-12	2011	These results indicate that a contaminant in municipal tap water is likely causing NTDs in mice.	Water	59-64	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	55-58
21824472-9	2011	Pretreatment of AAV-CAT significantly decreased the levels of H(2)O(2), MDA, 8-OHdG and nitrotyrosine, increased the catalase activity, and prevented the reduction of a- and b- waves in the I/R with AAV-CAT group compare with the I/R with vehicle group (p&lt;0.01).	Water	62-67	catalase	Rattus norvegicus	20-23
21357632-8	2011	Meanwhile, at the same exposure dose, water-soluble fraction caused more significant increase of MDA, IL-6, TNF-alpha and P-selectin and decrease of cell viability and NO when compared to organic extracts.	Water	38-43	interleukin 6	Homo sapiens	102-106
21357632-8	2011	Meanwhile, at the same exposure dose, water-soluble fraction caused more significant increase of MDA, IL-6, TNF-alpha and P-selectin and decrease of cell viability and NO when compared to organic extracts.	Water	38-43	tumor necrosis factor	Homo sapiens	108-117
21199326-5	2011	Characterization of the cognitive function of p60TRP transgenic mice using the radial arm water maze test demonstrated that p60TRP improved memory and learning abilities.	Water	90-95	basic helix-loop-helix family member B9	Rattus norvegicus	124-130
21604292-2	2011	The T(2) of water, T(2,w) , in muscle lengthens with both myocellular damage and inflammation and is typically measured using multiple spin-echo or Carr-Purcell-Meiboom-Gill acquisitions.	Water	12-17	arrestin 3	Homo sapiens	148-152
21993792-5	2011	Phylogenetic analyses indicated that BgAQP belongs to the PRIP group of insect AQPs, previously suggested to be water specific.	Water	112-117	nuclear receptor coactivator 6 L homeolog	Xenopus laevis	58-62
21993792-6	2011	However, ectopic expression of BgAQP in Xenopus laevis oocytes demonstrated that this AQP transports water and modest amounts of urea, but not glycerol, which suggests that the PRIP group of insect AQPs may have heterogeneous solute preferences.	Water	101-106	nuclear receptor coactivator 6 L homeolog	Xenopus laevis	177-181
21590769-8	2011	Non-invasive multiparametric quantitative MRI, including the measurement of native T(1) and T(2) relaxation times and apparent water diffusion coefficient, was indicative of higher cellularity in DDAH1-expressing xenografts, which was confirmed by histological quantification of necrosis.	Water	127-132	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	196-201
21831701-10	2011	The proposed method was successfully utilized for the determination of Pb(II) in tap water, polluted river water and industrial waste water samples.	Water	85-90	submaxillary gland androgen regulated protein 3B	Homo sapiens	71-77
22111323-6	2011	Diuretics more effectively contribute to the balance of sodium and volume of water, when used with ACE inhibitor and ARB.	Water	77-82	angiotensin I converting enzyme	Homo sapiens	99-102
21855403-3	2011	The chemosensor exhibited selective absorbance enhancement to Ag(I) ions in water samples over other metal ions at 438 nm, with a linear range of 0.4-500 muM (r(2)=0.999) and a limit of detection 0.07 muM of Ag(I) ions with UV-vis spectrophotometer detection.	Water	76-81	latexin	Homo sapiens	154-157
21855403-3	2011	The chemosensor exhibited selective absorbance enhancement to Ag(I) ions in water samples over other metal ions at 438 nm, with a linear range of 0.4-500 muM (r(2)=0.999) and a limit of detection 0.07 muM of Ag(I) ions with UV-vis spectrophotometer detection.	Water	76-81	latexin	Homo sapiens	201-204
21905722-5	2011	The catalase (CAT) activity increased when SMCs were stress induced with H(2)O(2) in the absence or presence of TC incubation (P &lt; 0.001).	Water	73-78	catalase	Homo sapiens	4-12
21776527-3	2011	The secondary coordination interactions binding between the Co(III) molecules and p-sulfonatocalix[4]arene have also been investigated in water using NMR techniques.	Water	138-143	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	60-67
21330168-9	2011	AQP3 and AQP5 were present in the nictitating membrane indicating that they play a role in water transport within the membrane.	Water	91-96	aquaporin 3	Canis lupus familiaris	0-4
21330168-9	2011	AQP3 and AQP5 were present in the nictitating membrane indicating that they play a role in water transport within the membrane.	Water	91-96	aquaporin 5	Canis lupus familiaris	9-13
22063564-10	2011	A total of 6 samples of urine and 12 samples of brain from control rats and another 6 samples of urine and 12 samples of brain from rats fed with tap water rich in lead acetate were used in this research.	Water	150-155	nuclear RNA export factor 1	Rattus norvegicus	146-149
21916483-0	2011	Novel water-soluble red-emitting poly(p-phenylenevinylene) derivative: synthesis, characterization, and fluorescent acetylcholinesterase assays.	Water	6-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-136
21905722-5	2011	The catalase (CAT) activity increased when SMCs were stress induced with H(2)O(2) in the absence or presence of TC incubation (P &lt; 0.001).	Water	73-78	catalase	Homo sapiens	14-17
21732909-0	2011	Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1.	Water	0-5	solute carrier family 1 member 3	Homo sapiens	82-87
21732909-3	2011	The human glial glutamate transporter EAAT1 (excitatory amino acid transporter 1) also allows significant passive and active water transport, which suggests that water permeation through glutamate transporters may play an important role in glial cell homoeostasis.	Water	125-130	solute carrier family 1 member 3	Homo sapiens	38-43
21732909-3	2011	The human glial glutamate transporter EAAT1 (excitatory amino acid transporter 1) also allows significant passive and active water transport, which suggests that water permeation through glutamate transporters may play an important role in glial cell homoeostasis.	Water	125-130	solute carrier family 1 member 3	Homo sapiens	45-80
21732909-3	2011	The human glial glutamate transporter EAAT1 (excitatory amino acid transporter 1) also allows significant passive and active water transport, which suggests that water permeation through glutamate transporters may play an important role in glial cell homoeostasis.	Water	162-167	solute carrier family 1 member 3	Homo sapiens	38-43
21732909-3	2011	The human glial glutamate transporter EAAT1 (excitatory amino acid transporter 1) also allows significant passive and active water transport, which suggests that water permeation through glutamate transporters may play an important role in glial cell homoeostasis.	Water	162-167	solute carrier family 1 member 3	Homo sapiens	45-80
21892456-0	2011	13C-NMR quantification of proton exchange at LewisX hydroxyl groups in water.	Water	71-76	fucosyltransferase 4	Homo sapiens	45-51
21616474-1	2011	Stabilization of oil-in-water emulsion films from PEO-PPO-PEO triblock copolymers is described in terms of interaction surface forces.	Water	24-29	protoporphyrinogen oxidase	Homo sapiens	54-57
21881645-1	2011	A method for solubilization of pristine fullerene (C(60)) in water was proposed by directly using bovine serum albumin (BSA) as a "solubilizer" by means of the unfolding mechanism.	Water	61-66	albumin	Homo sapiens	105-118
21858313-0	2011	A versatile water soluble fluorescent probe for ratiometric sensing of Hg2+ and bovine serum albumin.	Water	12-17	albumin	Homo sapiens	87-100
21907714-3	2011	To address this issue, we solubilized the insoluble ephrin-B2 cytoplasmic domain in unsalted water and first confirmed using NMR spectroscopy that it is only partially folded.	Water	93-98	ephrin B2	Homo sapiens	52-61
21894984-6	2011	Furthermore, the release of 1-MCP from the complex can be realized with different solutions such as sodium bicarbonate, benzoic acid, and distilled water.	Water	148-153	CD46 molecule	Homo sapiens	30-33
21889640-7	2011	For detection of 2,4,6-trinitrotoluene, the chloroform-based fluorescent microparticles achieved a lower limit of detection of 0.1 muM, as compared to 100 muM for the water-based fluorescent microparticles.	Water	167-172	latexin	Homo sapiens	155-158
21992339-3	2011	In this work, we have carried out atomistic molecular dynamics simulations to explore the heterogeneous dynamics of water molecules present in different regions around a complex formed between the DNA binding domain of human TRF1 protein and a telomeric DNA.	Water	116-121	telomeric repeat binding factor 1	Homo sapiens	225-229
21989311-5	2011	The marked increase in glucose level, protein content and lactate dehydrogenase (LDH) activity was observed in the cell supernatant of S. aureus exposed to the water-soluble chitosan derivative in deionized water.	Water	160-165	AT695_RS04475	Staphylococcus aureus	58-79
21989311-5	2011	The marked increase in glucose level, protein content and lactate dehydrogenase (LDH) activity was observed in the cell supernatant of S. aureus exposed to the water-soluble chitosan derivative in deionized water.	Water	160-165	AT695_RS04475	Staphylococcus aureus	81-84
21989311-5	2011	The marked increase in glucose level, protein content and lactate dehydrogenase (LDH) activity was observed in the cell supernatant of S. aureus exposed to the water-soluble chitosan derivative in deionized water.	Water	207-212	AT695_RS04475	Staphylococcus aureus	58-79
21989311-5	2011	The marked increase in glucose level, protein content and lactate dehydrogenase (LDH) activity was observed in the cell supernatant of S. aureus exposed to the water-soluble chitosan derivative in deionized water.	Water	207-212	AT695_RS04475	Staphylococcus aureus	81-84
21877718-1	2011	Induction of the peroxidase activity of cytochrome c (cyt c) by cardiolipin (CL) and H(2)O(2) in mitochondria is suggested to be a key event in early apoptosis.	Water	85-90	cytochrome c, somatic	Homo sapiens	40-52
21877718-1	2011	Induction of the peroxidase activity of cytochrome c (cyt c) by cardiolipin (CL) and H(2)O(2) in mitochondria is suggested to be a key event in early apoptosis.	Water	85-90	cytochrome c, somatic	Homo sapiens	54-59
21753077-1	2011	Cytochrome P-450 metabolites of arachidonic acid, the epoxyeicosatrienoic acids (EETs) and hydrogen peroxide (H(2)O(2)), are important signaling molecules in the kidney.	Water	110-115	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
21753077-3	2011	To determine the physiological contribution of H(2)O(2), catalase is used to inactivate H(2)O(2).	Water	47-52	catalase	Rattus norvegicus	57-65
21753077-3	2011	To determine the physiological contribution of H(2)O(2), catalase is used to inactivate H(2)O(2).	Water	88-93	catalase	Rattus norvegicus	57-65
21188596-2	2011	Previously, we found that PG102, a water-soluble extract prepared from the edible fruits of Actinidia arguta, can effectively reduce IgE levels using murine models.	Water	35-40	immunoglobulin heavy constant epsilon	Homo sapiens	133-136
21677305-2	2011	Previously, we showed in mice that the permeability to water and cryoprotectants of oocytes and embryos at early cleavage stages (early embryos) is low because these molecules move across the plasma membrane predominantly by simple diffusion through the lipid bilayer, whereas permeability of morulae and blastocysts is high because of a water channel, aquaporin 3 (AQP3).	Water	55-60	aquaporin 3	Mus musculus	353-364
21677305-2	2011	Previously, we showed in mice that the permeability to water and cryoprotectants of oocytes and embryos at early cleavage stages (early embryos) is low because these molecules move across the plasma membrane predominantly by simple diffusion through the lipid bilayer, whereas permeability of morulae and blastocysts is high because of a water channel, aquaporin 3 (AQP3).	Water	55-60	aquaporin 3	Mus musculus	366-370
22026997-4	2011	PEP-1-catalase (PEP-1- CAT) was transduced into astrocytes in a time- and dose-dependent manner, reducing cellular toxicity induced by H(2)O(2).	Water	135-140	catalase	Homo sapiens	0-14
22026997-4	2011	PEP-1-catalase (PEP-1- CAT) was transduced into astrocytes in a time- and dose-dependent manner, reducing cellular toxicity induced by H(2)O(2).	Water	135-140	catalase	Homo sapiens	16-26
21794891-2	2011	The summed total concentration of all six PCB congeners ranged from 13 to 72 ng L(-1) in water, 0.6-2.4 ng g(-1) dry weight (d.w.) in surface sediment, and from non-detectable to 2.2 ng g(-1) d.w. in sediment core samples.	Water	89-94	pyruvate carboxylase	Homo sapiens	42-45
21628092-0	2011	The influence of size, structure and hydrophilicity of model surfactants on the adsorption of lysozyme to oil-water interface--interfacial shear measurements.	Water	110-115	lysozyme	Homo sapiens	94-102
21628092-7	2011	The adsorption of lysozyme to the oil-water interface results in the formation of a viscoelastic film.	Water	38-43	lysozyme	Homo sapiens	18-26
21628092-9	2011	The more hydrophilic surfactants are more effective in hindering lysozyme adsorption to oil-water interfaces.	Water	92-97	lysozyme	Homo sapiens	65-73
21887695-5	2011	Transitory reductions in IL-10 and IL-12 levels also were observed after swimming at 31 C. The cytokine response to swimming was modified when the water temperature was increased to 38 C. Although exercise at 38 C also led to IL-6 secretion, the peak in IL-6 production occurred 6 h after exercise, and IL-6 levels were significantly lower than those observed after maximum swimming at 31 C (p = 0 030).	Water	147-152	interleukin 10	Mus musculus	25-30
21887695-5	2011	Transitory reductions in IL-10 and IL-12 levels also were observed after swimming at 31 C. The cytokine response to swimming was modified when the water temperature was increased to 38 C. Although exercise at 38 C also led to IL-6 secretion, the peak in IL-6 production occurred 6 h after exercise, and IL-6 levels were significantly lower than those observed after maximum swimming at 31 C (p = 0 030).	Water	147-152	interleukin 6	Mus musculus	226-230
21887695-5	2011	Transitory reductions in IL-10 and IL-12 levels also were observed after swimming at 31 C. The cytokine response to swimming was modified when the water temperature was increased to 38 C. Although exercise at 38 C also led to IL-6 secretion, the peak in IL-6 production occurred 6 h after exercise, and IL-6 levels were significantly lower than those observed after maximum swimming at 31 C (p = 0 030).	Water	147-152	interleukin 6	Mus musculus	254-258
21887695-5	2011	Transitory reductions in IL-10 and IL-12 levels also were observed after swimming at 31 C. The cytokine response to swimming was modified when the water temperature was increased to 38 C. Although exercise at 38 C also led to IL-6 secretion, the peak in IL-6 production occurred 6 h after exercise, and IL-6 levels were significantly lower than those observed after maximum swimming at 31 C (p = 0 030).	Water	147-152	interleukin 6	Mus musculus	254-258
22040556-9	2011	CONCLUSIONS: The decreased AQP8 expression in MC patients indicates that chronic use of laxatives containing anthraquinone may cause reduced water absorption.	Water	141-146	aquaporin 8	Homo sapiens	27-31
21871666-2	2011	Aquaporin 3 (AQP3), a water and glycerol transporting protein, is highly expressed in immature DCs.	Water	22-27	aquaporin 3	Mus musculus	0-11
23505824-4	2011	Water quality data during the period 2007-2009 show that 544 locations out of 1407 locations exceeded 45 mgl(-1), the allowable NO3 level for drinking water.	Water	0-5	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
23505824-4	2011	Water quality data during the period 2007-2009 show that 544 locations out of 1407 locations exceeded 45 mgl(-1), the allowable NO3 level for drinking water.	Water	151-156	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
21848649-1	2011	We studied the effects of water deprivation (WD) on the phosphorylation of tyrosine kinase B (TrkB) and NMDA receptor subunits in the supraoptic nucleus (SON) of the rat.	Water	26-31	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	75-92
21848649-1	2011	We studied the effects of water deprivation (WD) on the phosphorylation of tyrosine kinase B (TrkB) and NMDA receptor subunits in the supraoptic nucleus (SON) of the rat.	Water	26-31	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	94-98
21865594-1	2011	Superoxide dismutase 1 (Sod1) is an important antioxidative enzyme that converts superoxide anions to hydrogen peroxide and water.	Water	124-129	superoxide dismutase 1	Homo sapiens	0-22
21865594-1	2011	Superoxide dismutase 1 (Sod1) is an important antioxidative enzyme that converts superoxide anions to hydrogen peroxide and water.	Water	124-129	superoxide dismutase 1	Homo sapiens	24-28
21871666-2	2011	Aquaporin 3 (AQP3), a water and glycerol transporting protein, is highly expressed in immature DCs.	Water	22-27	aquaporin 3	Mus musculus	13-17
21624628-1	2011	A model of sedimentary oxygen demand (SOD) for stagnant water in a lake or a reservoir is presented.	Water	56-61	superoxide dismutase 1	Homo sapiens	38-41
23781462-2	2011	MATERIALS AND METHODS: The baseline separation for guaifenesin and all impurities was achieved by utilizing a Water Symmetry C18 (150 mm x 4.6 mm) 5 mum column particle size and a gradient elution method.	Water	110-115	Bardet-Biedl syndrome 9	Homo sapiens	125-128
21742779-10	2011	Upon exposure to H(2)O(2), Akt was intensely phosphorylated in the first 30 min, concurrently with mammalian target of rapamycin inactivation and autophagy, and it was dephosphorylated at 2 h, when &gt; 50% of the cells were dead.	Water	17-22	AKT serine/threonine kinase 1	Homo sapiens	27-30
21793635-0	2011	Influence of aquaporin-1 gene polymorphism on water retention in liver cirrhosis.	Water	46-51	aquaporin 1 (Colton blood group)	Homo sapiens	13-24
21793635-13	2011	CONCLUSIONS: Our results suggest that the rs1049305 (C/G, UTR3) AQP1 polymorphism could be involved in the genetic susceptibility to develop water retention in patients with liver cirrhosis.	Water	141-146	aquaporin 1 (Colton blood group)	Homo sapiens	64-68
21624628-4	2011	SOD is found to be substantially limited by oxygen transfer in the water column when water is stagnant.	Water	67-72	superoxide dismutase 1	Homo sapiens	0-3
21624628-4	2011	SOD is found to be substantially limited by oxygen transfer in the water column when water is stagnant.	Water	85-90	superoxide dismutase 1	Homo sapiens	0-3
21624628-5	2011	When flow over the sediment surface is present, SOD becomes larger than that for stagnant water, depending on flow velocity and the biochemical oxygen uptake rate in the sediment.	Water	90-95	superoxide dismutase 1	Homo sapiens	48-51
21624628-7	2011	The difference between SOD with fluid flow and SOD for stagnant water becomes significant as the biochemical oxygen uptake rate becomes larger, i.e. SOD is 10-100 times larger when flow over the sediment surface is present.	Water	64-69	superoxide dismutase 1	Homo sapiens	23-26
21624628-7	2011	The difference between SOD with fluid flow and SOD for stagnant water becomes significant as the biochemical oxygen uptake rate becomes larger, i.e. SOD is 10-100 times larger when flow over the sediment surface is present.	Water	64-69	superoxide dismutase 1	Homo sapiens	47-50
21624628-7	2011	The difference between SOD with fluid flow and SOD for stagnant water becomes significant as the biochemical oxygen uptake rate becomes larger, i.e. SOD is 10-100 times larger when flow over the sediment surface is present.	Water	64-69	superoxide dismutase 1	Homo sapiens	47-50
21794868-2	2011	The obtained C18-functionalized Fe(3)O(4)@mSiO(2) microspheres possess numerous C18 groups anchored in the interior pore-walls, large surface area (274.7 m(2)/g, high magnetization (40.8 emu/g) and superparamagnetism, uniform mesopores (4.1 nm), which makes them ideal absorbents for simple, fast, and efficient extraction and enrichment of hydrophobic organic compounds in water samples.	Water	374-379	Bardet-Biedl syndrome 9	Homo sapiens	13-16
22242435-0	2011	[Effect of water extract from traditional Chinese medicines Rehmannia glutinosa, Scrophularia ningpoensis, Asparagus cochinchinensis and Ophiopogon japonicas on contents of CYP450 and activities of CYP3A, CYP2E1 and CYP1A2 in rat].	Water	11-16	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	198-203
22242435-0	2011	[Effect of water extract from traditional Chinese medicines Rehmannia glutinosa, Scrophularia ningpoensis, Asparagus cochinchinensis and Ophiopogon japonicas on contents of CYP450 and activities of CYP3A, CYP2E1 and CYP1A2 in rat].	Water	11-16	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	205-211
22242435-1	2011	OBJECTIVE: To study the effects of the water extract of Rehmannia glutionsa, Scrophularia ningpoensis, Asparagus cochinchinensis and Ophiopogon japonicas, which are the drug from Tianwang Buxin Wan from nourishing vin, on the content of cytohrome P450 (CYP450) in rat and the activities of CYP3A, CYP2E1 and CYP1A2 to investigate the role of CYP450 in the biotransformation of Tianwang Buxin Wan.	Water	39-44	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	290-295
22242435-1	2011	OBJECTIVE: To study the effects of the water extract of Rehmannia glutionsa, Scrophularia ningpoensis, Asparagus cochinchinensis and Ophiopogon japonicas, which are the drug from Tianwang Buxin Wan from nourishing vin, on the content of cytohrome P450 (CYP450) in rat and the activities of CYP3A, CYP2E1 and CYP1A2 to investigate the role of CYP450 in the biotransformation of Tianwang Buxin Wan.	Water	39-44	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	297-303
22242435-4	2011	The water extract of R. glutionsa obviously decreased the contents of P450 (P &lt; 0.01) and increased the activity of CYP3A (P &lt; 0.01) and CYP1A2 (P &lt;0.05).	Water	4-9	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	119-124
22242435-5	2011	The water extract of S. ningpoensis decreased the contents of P450 (P &lt; 0.05) and significantly increased CYP3A and CYP1A2 activities (P &lt; 0.01).	Water	4-9	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	109-114
21866979-2	2011	In the present study, the interaction of luminescent water-soluble gold nanoparticles (AuNP-1 Eu-nta), obtained through the self-assembly of a naphthalene beta-diketone antenna with a Eu(III) cyclen complex tethered to the gold surface via a C(12) alkyl thiol spacer, with bovine serum albumin (BSA) was investigated.	Water	53-58	albumin	Homo sapiens	280-293
21795700-4	2011	High concentrations of exogenous H(2)O(2) are required to elevate intracellular H(2)O(2), probably because catalase, the enzyme that promotes the decomposition of H(2)O(2) to H(2)O and O(2), is highly expressed in A6 cells.	Water	33-39	catalase	Homo sapiens	107-115
21795700-4	2011	High concentrations of exogenous H(2)O(2) are required to elevate intracellular H(2)O(2), probably because catalase, the enzyme that promotes the decomposition of H(2)O(2) to H(2)O and O(2), is highly expressed in A6 cells.	Water	33-38	catalase	Homo sapiens	107-115
21795700-4	2011	High concentrations of exogenous H(2)O(2) are required to elevate intracellular H(2)O(2), probably because catalase, the enzyme that promotes the decomposition of H(2)O(2) to H(2)O and O(2), is highly expressed in A6 cells.	Water	80-85	catalase	Homo sapiens	107-115
21794868-0	2011	Preparation of magnetic core mesoporous shell microspheres with C18-modified interior pore-walls for fast extraction and analysis of phthalates in water samples.	Water	147-152	Bardet-Biedl syndrome 9	Homo sapiens	64-67
21851068-5	2011	A kinetics study in which CN(-) substitutes H(2)O on Co(III) shows that ACCbs is more labile than ACSYCbs; the second-order rate constant k(II) is between 4.6 (at 5  C) and 2.6 (at 35  C) times larger.	Water	44-49	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	53-60
21794868-6	2011	Under the optimized conditions, C18-functionalized Fe(3)O(4)@mSiO(2) microspheres were successfully used to analyze the real water samples.	Water	125-130	Bardet-Biedl syndrome 9	Homo sapiens	32-35
21843505-8	2011	Gene expression data published in Flybase (www.flybase.org) show that the Drosophila CG5811 gene is significantly expressed in the hindgut of adult flies, suggesting a role of insect RYamides in digestion or water reabsorption.	Water	208-213	RYamide receptor	Drosophila melanogaster	85-91
21932904-2	2011	We study, by numerical simulations, the interface between SPC/E water and a Kihara solute, which is a hard-sphere core with a Lennard-Jones layer at its surface.	Water	64-69	proline rich protein gene cluster	Homo sapiens	58-61
21786812-4	2011	Using five of these mesogenic molecules as additives to induce protein crystallization, we discover that molecules that can form liquid crystal phases in water are highly effective at inducing the crystal formation of lysozyme, even at concentrations significantly lower than that required for forming liquid crystal phases.	Water	154-159	lysozyme	Homo sapiens	218-226
21830821-2	2011	Over the range of solution compositions studied, from 0:100 to 100:0 methanol:water and 0:100 to 90:10 dioxane:water, evidence for 10 independent populations of bradykinin structures in solution is found.	Water	78-83	kininogen 1	Homo sapiens	161-171
21830821-2	2011	Over the range of solution compositions studied, from 0:100 to 100:0 methanol:water and 0:100 to 90:10 dioxane:water, evidence for 10 independent populations of bradykinin structures in solution is found.	Water	111-116	kininogen 1	Homo sapiens	161-171
21511033-2	2011	Even though AQP0 water permeability is 40-fold less than AQP1, AQP0 is selectively expressed in the fibers.	Water	17-22	major intrinsic protein of lens fiber	Mus musculus	12-16
21763803-5	2011	The achieved detection limit (0.007 muM PO(4)(3-)) is consistent with the requirement of the target water samples, and a wide quantification range (0.024-9.5 muM) was achieved using both detection systems.	Water	100-105	latexin	Homo sapiens	36-39
21633079-2	2011	In this work we have used the dialyzed squid giant axon to study the effects of two oxidants, SIN-1-buffered peroxynitrite and hydrogen peroxide (H(2)O(2)), on the Na(+)/Ca(2+) exchanger in the absence and presence of MgATP upregulation.	Water	146-151	solute carrier family 8 member A1	Homo sapiens	164-186
21703327-7	2011	Exposure of bronchial epithelial cells to O(2)(-), ONOO(-) or H(2)O(2) induced expression of CHOP, whereas NO alone did not.	Water	62-67	DNA damage inducible transcript 3	Homo sapiens	93-97
22332355-0	2011	[Bacterial expression of water-soluble domain of Lynx1, endogenic neuromodulator of human nicotinic acetylcholine receptors].	Water	25-30	Ly6/neurotoxin 1	Homo sapiens	49-54
21725208-4	2011	We first found that p34 (SEI-1) -expressing cells have enhanced resistance to hydrogen peroxide (H 2O 2).	Water	97-101	general transcription factor IIH subunit 3	Homo sapiens	20-23
21725208-4	2011	We first found that p34 (SEI-1) -expressing cells have enhanced resistance to hydrogen peroxide (H 2O 2).	Water	97-101	SERTA domain containing 1	Homo sapiens	25-30
21486183-11	2011	Two genes, (Erecta and alx8), which control water use efficiency; have been cloned in Arabidopsis thaliana.	Water	44-49	SAL1 phosphatase-like protein	Arabidopsis thaliana	23-27
21790145-10	2011	Preferential scavenging of water-soluble organic carbon (WSOC) by fog droplets was observed.	Water	27-32	zinc finger protein, FOG family member 1	Homo sapiens	66-69
21088889-3	2011	A quantitative analysis showed the total MC-LR concentrations of water samples ranged from non-detectable to 0.57 mug L-1 among the seven sampling sites.	Water	65-70	immunoglobulin kappa variable 1-16	Homo sapiens	118-121
21809940-1	2011	Recent studies have shown that the stable carbon isotope compositions of dissolved inorganic carbon (delta(13)C(DIC)) of water samples preserved with HgCl(2) and CuSO(4) vary.	Water	121-126	solute carrier family 25 member 10	Homo sapiens	112-115
21664866-6	2011	V. cholerae non-O1/O139 was cultured from the patient"s wound and the implicated recreational water; PFGE profiles of the water and patient isolates were not identical.	Water	122-127	sulfatase modifying factor 2	Homo sapiens	101-105
22028255-0	2011	[Antidiuretic hormone: not just a question of water].	Water	46-51	arginine vasopressin	Homo sapiens	1-21
21809940-3	2011	To test the effect of preservation on the delta(13)C value of DIC in different types of water samples, a set of water samples with different DIC concentrations was preserved using different methods, including preserving with inhibitors (CuSO(4) or HgCl(2)), preserving under frozen conditions, filtering through a 0.4 mu m paper filter, and the DIC species precipitated in the form of solid BaCO(3).	Water	88-93	solute carrier family 25 member 10	Homo sapiens	62-65
21809940-5	2011	The delta(13)C(DIC) of the water samples preserved under frozen conditions and the precipitated DIC as BaCO(3) are also more positive than original water samples.	Water	27-32	solute carrier family 25 member 10	Homo sapiens	15-18
21789333-2	2011	Performance reference compound-corrected data from the passive samplers deployed at three sites along the river were used to track PCB contamination in the overlying water.	Water	166-171	pyruvate carboxylase	Homo sapiens	131-134
21789333-5	2011	Comparison of passive sampling-based overlying water concentrations with total concentrations measured in bed sediments supports the possibility of further PCB sources upstream of the study area.	Water	47-52	pyruvate carboxylase	Homo sapiens	156-159
21641610-0	2011	How to obtain a well-spread monolayer of lysozyme at the air/water interfaces.	Water	61-66	lysozyme	Homo sapiens	41-49
23717080-4	2011	In the present study, we demonstrate that KRG water extract induces HO-1 expression in human umbilical vein endothelial cells (HUVECs) and possible involvement of the anti-oxidant transcription factor nuclear factor-eythroid 2-related factor 2 (Nrf2).	Water	46-51	NFE2 like bZIP transcription factor 2	Homo sapiens	201-243
23717080-4	2011	In the present study, we demonstrate that KRG water extract induces HO-1 expression in human umbilical vein endothelial cells (HUVECs) and possible involvement of the anti-oxidant transcription factor nuclear factor-eythroid 2-related factor 2 (Nrf2).	Water	46-51	NFE2 like bZIP transcription factor 2	Homo sapiens	245-249
21689108-8	2011	Furthermore, neuroserpin-deficient J20-transgenic mice have near normal performances in the Morris water maze, in contrast to the spatial memory defects seen in J20-transgenic mice.	Water	99-104	serine (or cysteine) peptidase inhibitor, clade I, member 1	Mus musculus	13-24
22097535-0	2011	TiCp*(OMe)3 versus Ti(OMe)4 in atomic layer deposition of TiO2 with water--ab initio modelling of atomic layer deposition surface reactions.	Water	68-73	pleckstrin and Sec7 domain containing 4	Homo sapiens	0-4
21525850-5	2011	About half of the ultrafiltration generated by L-carnitine reflected facilitated water transport by aquaporin-1 (AQP1) water channels of endothelial cells.	Water	81-86	aquaporin 1 (Colton blood group)	Homo sapiens	100-111
21525850-5	2011	About half of the ultrafiltration generated by L-carnitine reflected facilitated water transport by aquaporin-1 (AQP1) water channels of endothelial cells.	Water	81-86	aquaporin 1 (Colton blood group)	Homo sapiens	113-117
21525850-5	2011	About half of the ultrafiltration generated by L-carnitine reflected facilitated water transport by aquaporin-1 (AQP1) water channels of endothelial cells.	Water	119-124	aquaporin 1 (Colton blood group)	Homo sapiens	100-111
21525850-5	2011	About half of the ultrafiltration generated by L-carnitine reflected facilitated water transport by aquaporin-1 (AQP1) water channels of endothelial cells.	Water	119-124	aquaporin 1 (Colton blood group)	Homo sapiens	113-117
21523511-1	2011	PURPOSE: Several poorly water-soluble drugs have previously been shown to bind to intestinal (I-FABP) and liver fatty acid binding protein (L-FABP) in vitro.	Water	24-29	fatty acid binding protein 1	Rattus norvegicus	106-138
21523511-1	2011	PURPOSE: Several poorly water-soluble drugs have previously been shown to bind to intestinal (I-FABP) and liver fatty acid binding protein (L-FABP) in vitro.	Water	24-29	fatty acid binding protein 1	Rattus norvegicus	140-146
21564354-6	2011	A mutation of the Arabidopsis thaliana AtPIP1;2 gene, which was characterized as a non-water transporting but CO2 transport-facilitating aquaporin in heterologous expression systems, correlated with a reduction in photosynthesis under a wide range of atmospheric CO2 concentrations.	Water	87-92	plasma membrane intrinsic protein 1B	Arabidopsis thaliana	39-47
22060488-4	2011	Weak zeta potential of the water-HOPG interface or the water-OTS-silicon interface at acidic pH ensures that the added salt will have imperceptible effect on the corresponding preformed surface nanobubbles, validating the experimental observations.	Water	55-60	OTSC1	Homo sapiens	61-64
21725571-4	2011	This allows us to utilize the H(2)O(2)-thiamine fluorescent system for the quantitative analysis of thrombin.	Water	30-35	coagulation factor II, thrombin	Homo sapiens	100-108
21700492-5	2011	The calculated results of the Cu2+ doped [Zn(mein)2(H2O)4] (sac)2 indicate that Cu2+ ion contains two different complexes and each complexes are located in different chemical environments and each environment contains two magnetically inequivalent Cu2+ sites in distinct orientations occupying substitutional positions in the lattice.	Water	52-55	inositol polyphosphate-5-phosphatase F	Homo sapiens	60-65
21637967-7	2011	At initial stage of drought stress, the plant system may modulate the root growth behavior by regulating MYB60 expression, thus promotes root growth for increased water uptake.	Water	163-168	myb domain protein 60	Arabidopsis thaliana	105-110
21809858-6	2011	The proposed Co(III) binding site may enable efficient collection of electrons generated from photochemical water oxidation by PSII immobilized on an electrode surface.	Water	108-113	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	16-19
21640997-1	2011	The mechanism of the enzymatic action of Savinase on an insulin substrate organized in a monolayer at the air-water interface was studied.	Water	110-115	insulin	Homo sapiens	56-63
21806969-4	2011	In contrast, MKK4-overexpressing transgenic plants showed tolerance to high salt as well as lower water-loss rates under dehydration conditions.	Water	98-103	mitogen-activated protein kinase kinase 4	Arabidopsis thaliana	13-17
21847189-6	2011	For example, the insertion losses below 1 dB were demonstrated for 50 mum or shorter open path prototype microcells, when immersed in dematerialized water.	Water	149-154	latexin	Homo sapiens	70-73
21831323-6	2011	In asthmatic mice (Tap water/Der f group), the intensity of airway resistance increased simultaneously with the increase in acetylcholine concentration in a dose-dependant way.	Water	23-28	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	19-22
21709869-5	2011	The lamellar phase is stable under excess water conditions up to temperatures of at least 70  C. Approximate partial binary amphiphile-water phase diagrams generated for the three unsaturated C18 amphiphiles indicate that the excess water point for each amphiphile occurs at ~60% (w/w) amphiphile.	Water	135-140	Bardet-Biedl syndrome 9	Homo sapiens	192-195
21659526-5	2011	Our results illustrate the importance of the intact hydrogen-bonding network for dim-light detection, revealing the functional roles of water molecules in rhodopsin.	Water	136-141	rhodopsin	Homo sapiens	155-164
21652700-9	2011	Besides HG, exposure of cells to oxidants H(2)O(2) and methylglyoxal up-regulated MIOX expression and its phosphorylation and activity, whereas antioxidants N-acetylcysteine, beta-naphthoflavone, and tertiary butyl hydroquinone reduced MIOX expression.	Water	42-47	inositol oxygenase	Sus scrofa	82-86
21652700-9	2011	Besides HG, exposure of cells to oxidants H(2)O(2) and methylglyoxal up-regulated MIOX expression and its phosphorylation and activity, whereas antioxidants N-acetylcysteine, beta-naphthoflavone, and tertiary butyl hydroquinone reduced MIOX expression.	Water	42-47	inositol oxygenase	Sus scrofa	236-240
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Water	53-58	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
21668007-3	2011	The results show that, upon adsorption to both oil-water interfaces, beta-Lg went through a beta-sheet to alpha-helix transition with a corresponding loss of its globular tertiary structure.	Water	51-56	amyloid beta precursor protein	Homo sapiens	90-96
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Water	53-58	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
21605854-10	2011	In conclusion, arsenic metabolic genes, PNP, As3MT, and GSTO, may exacerbate the formation of atherosclerosis in individuals with high levels of arsenic concentration in well water (&gt;50mug/l).	Water	175-180	purine nucleoside phosphorylase	Homo sapiens	40-43
22090887-2	2011	In the mol-ecule, the Co(II) atom is six-coordinated in a distorted octa-hedral environment, binding to the bridging O atom of the bicyclo-heptane unit, to two O atoms from monodentate carboxyl-ate groups and to three water O atoms.	Water	218-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
22090917-1	2011	In the title complex, [Co(C(22)H(18)N(2)O(4))(CN)(H(2)O)] CH(3)CN, the Co(III) ion is six-coordinated in a distorted octa-hedral environment defined by two N atoms and two O atoms from a salen ligand in the equatorial plane and one O atom from a water mol-ecule and one C atom from a cyanide group at the axial positions.	Water	50-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	71-78
22090917-1	2011	In the title complex, [Co(C(22)H(18)N(2)O(4))(CN)(H(2)O)] CH(3)CN, the Co(III) ion is six-coordinated in a distorted octa-hedral environment defined by two N atoms and two O atoms from a salen ligand in the equatorial plane and one O atom from a water mol-ecule and one C atom from a cyanide group at the axial positions.	Water	246-251	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	71-78
21602469-6	2011	In cultured aorta segments of young (3 mo old) rats treatment with H(2)O(2) and high glucose significantly increases nuclear translocation of Nrf2 and upregulates the expression of Nrf2 target genes.	Water	67-72	NFE2 like bZIP transcription factor 2	Rattus norvegicus	142-146
21602469-6	2011	In cultured aorta segments of young (3 mo old) rats treatment with H(2)O(2) and high glucose significantly increases nuclear translocation of Nrf2 and upregulates the expression of Nrf2 target genes.	Water	67-72	NFE2 like bZIP transcription factor 2	Rattus norvegicus	181-185
21659008-2	2011	The effects of the addition of N,N-dimethylformamide (DMF) in the agarose-cyt-c film, water concentration in ionic liquids and exterior metal ions on the electrochemical behavior of cyt-c were monitored, and electrocatalytic properties of cyt-c were also done.	Water	86-91	cytochrome c, somatic	Homo sapiens	182-187
21659008-2	2011	The effects of the addition of N,N-dimethylformamide (DMF) in the agarose-cyt-c film, water concentration in ionic liquids and exterior metal ions on the electrochemical behavior of cyt-c were monitored, and electrocatalytic properties of cyt-c were also done.	Water	86-91	cytochrome c, somatic	Homo sapiens	182-187
21659008-4	2011	In addition, a certain amount of water in hydrophilic ionic liquids is necessary to maintain electrochemical activities of cyt-c, electrochemical performance of cyt-c is the best when the water content is 5.2% and 5.8% for 1-butyl-3-methylimidazolium bromide ([Bmim][Br]) and 1-butyl-3-methylimidazolium tetrafluoroborate([Bmim][BF(4)]) respectively.	Water	33-38	cytochrome c, somatic	Homo sapiens	123-128
21659008-4	2011	In addition, a certain amount of water in hydrophilic ionic liquids is necessary to maintain electrochemical activities of cyt-c, electrochemical performance of cyt-c is the best when the water content is 5.2% and 5.8% for 1-butyl-3-methylimidazolium bromide ([Bmim][Br]) and 1-butyl-3-methylimidazolium tetrafluoroborate([Bmim][BF(4)]) respectively.	Water	33-38	cytochrome c, somatic	Homo sapiens	161-166
21659008-4	2011	In addition, a certain amount of water in hydrophilic ionic liquids is necessary to maintain electrochemical activities of cyt-c, electrochemical performance of cyt-c is the best when the water content is 5.2% and 5.8% for 1-butyl-3-methylimidazolium bromide ([Bmim][Br]) and 1-butyl-3-methylimidazolium tetrafluoroborate([Bmim][BF(4)]) respectively.	Water	188-193	cytochrome c, somatic	Homo sapiens	123-128
21659008-4	2011	In addition, a certain amount of water in hydrophilic ionic liquids is necessary to maintain electrochemical activities of cyt-c, electrochemical performance of cyt-c is the best when the water content is 5.2% and 5.8% for 1-butyl-3-methylimidazolium bromide ([Bmim][Br]) and 1-butyl-3-methylimidazolium tetrafluoroborate([Bmim][BF(4)]) respectively.	Water	188-193	cytochrome c, somatic	Homo sapiens	161-166
21787340-2	2011	Latherin produces a significant reduction in water surface tension at low concentrations (&lt;=1 mg/ml), and probably acts as a wetting agent to facilitate evaporative cooling through a thick, waterproofed pelt.	Water	45-50	latherin	Equus caballus	0-8
21787340-6	2011	Neutron reflection experiments indicate that latherin adsorbs to the air/water interface, and that the protein undergoes significant conformational change and/or partial unfolding during incorporation into the interfacial layer.	Water	73-78	latherin	Equus caballus	45-53
22351255-0	2011	Removal of Pb(II) and Cd(II) ions from water by Fe and Ag nanoparticles prepared using electro-exploding wire technique.	Water	39-44	submaxillary gland androgen regulated protein 3B	Homo sapiens	11-28
21881396-6	2011	Patients with euvolemic or hypervolemic hyponatremia usually have inappropriately elevated levels of arginine vasopressin, which stimulates water reabsorption even in the presence of low serum osmolality.	Water	140-145	arginine vasopressin	Homo sapiens	110-121
21939115-0	2011	[The influence of single immersion in Dead Sea water on glucose, insulin, cortisol and C-peptide levels in type 2 diabetes mellitus patients].	Water	47-52	insulin	Homo sapiens	65-72
21939115-3	2011	OBJECTIVE: To compare the effects of a single immersion in sweet or mineral water on blood glucose, insulin, cortisol and c-peptide levels in patients with type 2 DM.	Water	76-81	insulin	Homo sapiens	122-131
21939115-0	2011	[The influence of single immersion in Dead Sea water on glucose, insulin, cortisol and C-peptide levels in type 2 diabetes mellitus patients].	Water	47-52	insulin	Homo sapiens	87-96
21110054-4	2011	The binding free energy of scFv:AMP without introducing an extra water into the binding pocket is much stronger than scFv:METH.	Water	65-70	immunglobulin heavy chain variable region	Homo sapiens	27-31
21766199-1	2011	The photosynthetic oxygen evolving complex (PSII-OEC) and the mitochondrial cytochrome c oxidase (CcO) not only catalyze anti-parallel reactions (the OEC oxidizes water to dioxygen, whereas CcO reduces dioxygen to water), they also share a number of uncanny molecular and mechanistic similarities.	Water	163-168	cytochrome c, somatic	Homo sapiens	76-88
21766199-1	2011	The photosynthetic oxygen evolving complex (PSII-OEC) and the mitochondrial cytochrome c oxidase (CcO) not only catalyze anti-parallel reactions (the OEC oxidizes water to dioxygen, whereas CcO reduces dioxygen to water), they also share a number of uncanny molecular and mechanistic similarities.	Water	214-219	cytochrome c, somatic	Homo sapiens	76-88
21441404-15	2011	HvPIP2;5, HvPIP2;2, and HvTIP1;1 are prime candidates to mediate water flow in cortical tissue.	Water	65-70	PIP2;2	Hordeum vulgare	10-18
21110054-7	2011	However, adding a water to the AMP (at the position of the methyl group of METH), the binding free energy of the scFv:AMP-H2O complex, is found to be significantly weaker than scFv:METH.	Water	122-125	immunglobulin heavy chain variable region	Homo sapiens	113-117
21110054-7	2011	However, adding a water to the AMP (at the position of the methyl group of METH), the binding free energy of the scFv:AMP-H2O complex, is found to be significantly weaker than scFv:METH.	Water	122-125	immunglobulin heavy chain variable region	Homo sapiens	176-180
21110054-9	2011	Decomposition of the binding energy into ligand-residue pair interactions shows that two residues (Tyr175 and Tyr177) have nearly-zero interactions with AMP in the scFv:AMP-H2O complex, whereas their interactions with METH in the scFv:METH complex are as large as -0.8 and -0.74 kcal mol(-1).	Water	173-176	immunglobulin heavy chain variable region	Homo sapiens	164-168
21605990-7	2011	The effect of hydrating water molecules located between uPA and uPAR is also investigated to be significant for the specific interactions between uPA and uPAR.	Water	24-29	plasminogen activator, urokinase	Homo sapiens	56-59
21605990-7	2011	The effect of hydrating water molecules located between uPA and uPAR is also investigated to be significant for the specific interactions between uPA and uPAR.	Water	24-29	plasminogen activator, urokinase	Homo sapiens	64-67
21110054-4	2011	The binding free energy of scFv:AMP without introducing an extra water into the binding pocket is much stronger than scFv:METH.	Water	65-70	immunglobulin heavy chain variable region	Homo sapiens	117-121
21110054-7	2011	However, adding a water to the AMP (at the position of the methyl group of METH), the binding free energy of the scFv:AMP-H2O complex, is found to be significantly weaker than scFv:METH.	Water	18-23	immunglobulin heavy chain variable region	Homo sapiens	113-117
21110054-7	2011	However, adding a water to the AMP (at the position of the methyl group of METH), the binding free energy of the scFv:AMP-H2O complex, is found to be significantly weaker than scFv:METH.	Water	18-23	immunglobulin heavy chain variable region	Homo sapiens	176-180
21603724-3	2011	H(2)O(2) treatment induced phosphorylation of cytosolic phospholipase A(2) (cPLA(2)) via the activation of extracellular-regulated kinase 1/2 (ERK1/2), increasing the production of lysophosphatidylethanolamine (LPE) and lysophosphatidylcholine (LPC).	Water	0-5	mitogen-activated protein kinase 3	Homo sapiens	143-149
21928623-6	2011	CONCLUSIONS: The classical Monte Carlo transport treatment is questionable for sub-1 keV electrons in condensed water as uncertainties on position and momentum must be large (relative to electron momentum and mean free path) to satisfy the quantum uncertainty principle.	Water	112-117	SUB1 regulator of transcription	Homo sapiens	79-84
22007516-7	2011	Water extract of Schisandra chinensis (100-500 microg x mL(-1)) also exhibited inhibition on the activity of CYP450 isozymes in vitro, whereas multiple administrations (1.5 g x kg(-1), qd x 7d) had significant induction of CYP2E1 and inhibition on CYP2D2, no effect on CYP2C6, CYP3A1/2, CYP1A2 or CYP2C11.	Water	0-5	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	223-229
21857803-3	2011	Nitrogen is also leached from agricultural lands as the water-soluble form NO3-, which increases nutrient overload in rivers, lakes, and oceans, causing "dead zones", reducing property values and the diversity of aquatic life, and damaging our drinking water and aquatic-associated industries such as fishing and tourism.	Water	56-61	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
22164840-13	2011	The snail areas increased to over 2% of historically accumulative snail areas 3-6 years after transmission interruption in lake, water-network endemic areas successively, while densities of living snails and infected snails were increased at the same year or 2-3 years later.	Water	129-134	snail family transcriptional repressor 1	Homo sapiens	4-9
22164840-13	2011	The snail areas increased to over 2% of historically accumulative snail areas 3-6 years after transmission interruption in lake, water-network endemic areas successively, while densities of living snails and infected snails were increased at the same year or 2-3 years later.	Water	129-134	snail family transcriptional repressor 1	Homo sapiens	66-71
21576273-7	2011	Clofilium also increased the fractional excretion of Na+, Cl- and water, but this was observed in both wild-type and knockout mice, suggesting that KCNE1 was regulating a chromanol-sensitive but clofilium-insensitive pathway.	Water	66-71	potassium voltage-gated channel, Isk-related subfamily, member 1	Mus musculus	148-153
21806149-5	2011	Three-body interactions within our newly developed E3B water simulation model prove to be critical in describing the proper balance between different hydrogen-bonded species, as (two-body) SPC/E, TIP4P, and TIP4P/2005 models fail to reproduce the positive feature.	Water	55-60	proline rich protein gene cluster	Homo sapiens	189-192
21641788-1	2011	The first polyurethane based magnetic-MIP for the selective detection of 1-naphthylamine (1-NA) in drinking water has been synthesised.	Water	108-113	major intrinsic protein of lens fiber	Homo sapiens	38-41
21576273-5	2011	In clearance studies the KCNE1 knockout mice had an increased fractional excretion of Na+, Cl-, HCO3(-) and water.	Water	108-113	potassium voltage-gated channel, Isk-related subfamily, member 1	Mus musculus	25-30
21648462-0	2011	Effects of Cu ions and explicit water molecules on the copper binding domain of amyloid precursor protein APP(131-189): a molecular dynamics study.	Water	32-37	amyloid beta precursor protein	Homo sapiens	80-105
21746928-8	2011	The life span of Zmpste24(-/-) mice was also extended with the supplementation of a histone deacetylase inhibitor, sodium butyrate, to drinking water.	Water	144-149	zinc metallopeptidase, STE24	Mus musculus	17-25
21767487-0	2011	C-terminus of apolipoprotein A-I removes phospholipids from a triolein/phospholipids/water interface, but the N-terminus does not: a possible mechanism for nascent HDL assembly.	Water	85-90	apolipoprotein A1	Homo sapiens	14-32
23140696-0	2011	The role of polyphenol oxidase and peroxidase in the browning of water caltrop pericarp during heat treatment.	Water	65-70	protoporphyrinogen oxidase	Homo sapiens	12-30
23140696-4	2011	PPO and POD activities dropped from 62 and 38units/g sample, respectively, as water temperature was increased from 30 to 80 C. Optimum pH and temperature for PPO activity was at pH 5.0, 25-45 C, and POD activity peaked at 60 C. High PPO and POD activities at 40-50 C resulted in degradation of phenolic compounds, which led to increased aggregation of browning pigments and discolouration (lower L-values) of the pericarp.	Water	78-83	protoporphyrinogen oxidase	Homo sapiens	0-3
23140696-4	2011	PPO and POD activities dropped from 62 and 38units/g sample, respectively, as water temperature was increased from 30 to 80 C. Optimum pH and temperature for PPO activity was at pH 5.0, 25-45 C, and POD activity peaked at 60 C. High PPO and POD activities at 40-50 C resulted in degradation of phenolic compounds, which led to increased aggregation of browning pigments and discolouration (lower L-values) of the pericarp.	Water	78-83	protoporphyrinogen oxidase	Homo sapiens	158-161
23140696-4	2011	PPO and POD activities dropped from 62 and 38units/g sample, respectively, as water temperature was increased from 30 to 80 C. Optimum pH and temperature for PPO activity was at pH 5.0, 25-45 C, and POD activity peaked at 60 C. High PPO and POD activities at 40-50 C resulted in degradation of phenolic compounds, which led to increased aggregation of browning pigments and discolouration (lower L-values) of the pericarp.	Water	78-83	protoporphyrinogen oxidase	Homo sapiens	158-161
21740555-9	2011	As regards the exposure-response relationship with arsenic in the drinking water, the respective activities of ALP, AST and ALT were found to be significantly increased in the high-exposure groups compared to the lowest-exposure groups before and after adjustments were made for different covariates.	Water	75-80	alkaline phosphatase, placental	Homo sapiens	111-114
21597156-1	2011	In this paper, we reported ultrasensitive lead ion detection in environmental water with pM sensitivity using aza-crown-ether-modified silver nanoparticles (ACE-Ag NPs) through dynamic light scattering (DLS).	Water	78-83	angiotensin I converting enzyme	Homo sapiens	157-160
21644504-0	2011	Optimized unlike-pair interactions for water-carbon dioxide mixtures described by the SPC/E and EPM2 models.	Water	39-44	proline rich protein gene cluster	Homo sapiens	86-89
21644504-1	2011	The unlike-pair interaction parameters for the SPC/E-EPM2 models have been optimized to reproduce the mutual solubility of water and carbon dioxide at the conditions of liquid-supercritical fluid phase equilibria.	Water	123-128	proline rich protein gene cluster	Homo sapiens	47-50
21644504-2	2011	An efficient global optimization of the parameters is achieved through an implementation of the coupling parameter approach, adapted to phase equilibria calculations in the Gibbs ensemble, that explicitly corrects for the overpolarization of the SPC/E water molecule in the nonpolar CO(2) environments.	Water	252-257	proline rich protein gene cluster	Homo sapiens	246-249
21682268-2	2011	In this study we compared the active sites of monomers and tetramers of human BChE and human AChE after performing molecular dynamics (MD) simulations in water-solvated systems.	Water	154-159	acetylcholinesterase (Cartwright blood group)	Homo sapiens	93-97
21740555-9	2011	As regards the exposure-response relationship with arsenic in the drinking water, the respective activities of ALP, AST and ALT were found to be significantly increased in the high-exposure groups compared to the lowest-exposure groups before and after adjustments were made for different covariates.	Water	75-80	solute carrier family 17 member 5	Homo sapiens	116-119
21634413-4	2011	The electroactive amount of cyt c is estimated by the deposited mass under the assumption of 50% coupled water.	Water	105-110	cytochrome c, somatic	Homo sapiens	28-33
21642618-3	2011	METHODS: The water-insoluble fraction of lens fiber cells was chemically cross-linked, and cross-linked peptides with the C terminus of AQP0 were identified by mass spectrometry.	Water	13-18	major intrinsic protein of lens fiber	Homo sapiens	136-140
21697602-2	2011	In the first unambiguous demonstration of IZD interactions with a PTP other than PTP1B, it is shown by X-ray crystallography that the IZD motif binds within the catalytic site of the Yersinia pestis PTP YopH by similarly displacing a highly conserved water molecule.	Water	251-256	YopH	Yersinia pestis	203-207
21727914-5	2011	The syndrome can also result from resistance to the antidiuretic effects of vasopressin on the kidney, either at the level of the vasopressin 2 receptor or the aquaporin 2 water channel (which mediates the re-absorption of water from urine), and is referred to as renal or nephrogenic diabetes insipidus.	Water	172-177	arginine vasopressin	Homo sapiens	76-87
21727914-5	2011	The syndrome can also result from resistance to the antidiuretic effects of vasopressin on the kidney, either at the level of the vasopressin 2 receptor or the aquaporin 2 water channel (which mediates the re-absorption of water from urine), and is referred to as renal or nephrogenic diabetes insipidus.	Water	223-228	arginine vasopressin	Homo sapiens	76-87
21639107-0	2011	Dinuclear Co(II)Co(III) mixed-valence and Co(III)Co(III) complexes with N- and O-donor ligands: characterization and water oxidation studies.	Water	117-122	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	19-22
21639107-0	2011	Dinuclear Co(II)Co(III) mixed-valence and Co(III)Co(III) complexes with N- and O-donor ligands: characterization and water oxidation studies.	Water	117-122	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	45-48
21431922-0	2011	Reproductive toxicity in male mice exposed to Nanjing City tap water.	Water	63-68	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	59-62
21639107-0	2011	Dinuclear Co(II)Co(III) mixed-valence and Co(III)Co(III) complexes with N- and O-donor ligands: characterization and water oxidation studies.	Water	117-122	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	45-48
21639107-5	2011	Moreover, the ability of the mixed-valence Co(II)Co(III) complex and the three related Co(III) complexes to electrocatalytically oxidize water was also investigated.	Water	137-142	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	52-55
21639107-5	2011	Moreover, the ability of the mixed-valence Co(II)Co(III) complex and the three related Co(III) complexes to electrocatalytically oxidize water was also investigated.	Water	137-142	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	49-56
21823389-2	2011	Failure was attributed to changes in lung physiology following submersion and inhalation of water that may have required ventilation pressures up to 40 cmH2O to treat the victim"s hypoxaemia.	Water	92-97	troponin T2, cardiac type	Homo sapiens	152-156
21029392-6	2011	These studies have identified plasma volume and urinary bladder stores as intrinsic stimuli that activate the formation of angiotensin II (AII) to stimulate water absorption behaviour.	Water	157-162	angiotensinogen	Homo sapiens	123-137
21029392-6	2011	These studies have identified plasma volume and urinary bladder stores as intrinsic stimuli that activate the formation of angiotensin II (AII) to stimulate water absorption behaviour.	Water	157-162	angiotensinogen	Homo sapiens	139-142
21486680-5	2011	Doxorubicin exposure increases dichlorofluorescein (DCF) intensity corresponding to the intracellular H(2)O(2) generation in myocytes; catalase (CAT) treatment, however, reduced this intensity and preserves cell viability.	Water	102-107	catalase	Rattus norvegicus	135-143
21486680-5	2011	Doxorubicin exposure increases dichlorofluorescein (DCF) intensity corresponding to the intracellular H(2)O(2) generation in myocytes; catalase (CAT) treatment, however, reduced this intensity and preserves cell viability.	Water	102-107	catalase	Rattus norvegicus	145-148
21431922-6	2011	The current study suggests that Nanjing City tap water is toxic to the reproductive system of mice and additional study to evaluate its effects on other species, including human beings, would be warranted.	Water	49-54	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	45-48
21942020-9	2011	Moreover, BaF2 is quite stable and insolvable in water and most organic solvents and it will not be dissolved by mobile phase or react with samples in TLC separation.	Water	49-54	BANF family member 2	Homo sapiens	10-14
21595828-6	2011	In comparison with the uncatalyzed reaction in water, the enzyme PDE4B provides a strong stabilization of the transition state, lowering the free energy barrier by 14 kcal mol(-1).	Water	47-52	phosphodiesterase 4B	Homo sapiens	65-70
21882554-5	2011	The data of this study showed a reduction in NO3 levels in the underground source water, which caused a reduction in the phytoplankton abundance.	Water	82-87	NBL1, DAN family BMP antagonist	Homo sapiens	45-48
20554636-6	2011	The ROS increase by exposure to PM(2.5) suspension, water-soluble and water-insoluble fractions of PM(2.5) triggered the activation of nuclear factor (NF)-kappaB, which means that PM(2.5) particles exert cytotoxicity by an apopotic process.	Water	52-57	nuclear factor kappa B subunit 1	Homo sapiens	135-161
20554636-6	2011	The ROS increase by exposure to PM(2.5) suspension, water-soluble and water-insoluble fractions of PM(2.5) triggered the activation of nuclear factor (NF)-kappaB, which means that PM(2.5) particles exert cytotoxicity by an apopotic process.	Water	70-75	nuclear factor kappa B subunit 1	Homo sapiens	135-161
20554636-7	2011	However, the induction of cytotoxicity by PM(2.5) suspension, water-soluble and water-insoluble fractions of PM(2.5) was reversed by pretreatment with superoxide dismutase (SOD).	Water	62-67	superoxide dismutase 1	Homo sapiens	151-171
20554636-7	2011	However, the induction of cytotoxicity by PM(2.5) suspension, water-soluble and water-insoluble fractions of PM(2.5) was reversed by pretreatment with superoxide dismutase (SOD).	Water	62-67	superoxide dismutase 1	Homo sapiens	173-176
20554636-7	2011	However, the induction of cytotoxicity by PM(2.5) suspension, water-soluble and water-insoluble fractions of PM(2.5) was reversed by pretreatment with superoxide dismutase (SOD).	Water	80-85	superoxide dismutase 1	Homo sapiens	151-171
20554636-7	2011	However, the induction of cytotoxicity by PM(2.5) suspension, water-soluble and water-insoluble fractions of PM(2.5) was reversed by pretreatment with superoxide dismutase (SOD).	Water	80-85	superoxide dismutase 1	Homo sapiens	173-176
21978706-1	2011	The present study aims to assess the protective role of the antioxidant enzyme catalase (CAT) with relation to hydrogen peroxide (H(2)O(2)) degradation in oxygen plus water on electrophysiological and fluorescence changes induced by in vitro ischemia and on brain damage produced by transient in vivo ischemia.	Water	167-172	catalase	Mus musculus	79-87
21786879-2	2011	Although it has been shown analytically that beta 1 for ideal waveguides, numerical and experimental results have shown that beta 1 for many realistic shallow water waveguides as well.	Water	159-164	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	45-51
21978706-1	2011	The present study aims to assess the protective role of the antioxidant enzyme catalase (CAT) with relation to hydrogen peroxide (H(2)O(2)) degradation in oxygen plus water on electrophysiological and fluorescence changes induced by in vitro ischemia and on brain damage produced by transient in vivo ischemia.	Water	167-172	catalase	Mus musculus	89-92
21786879-2	2011	Although it has been shown analytically that beta 1 for ideal waveguides, numerical and experimental results have shown that beta 1 for many realistic shallow water waveguides as well.	Water	159-164	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	125-131
21259292-3	2011	Whilst acceptable for determining aromatase effects using a cell-free approach, this method is unreliable for cell or tissue-based investigations as other cytochrome P-450 isoenzyme activities can similarly produce tritiated water and consequently confound interpretation of the aromatase data.	Water	225-230	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	155-171
21978706-8	2011	In the presence of H(2)O(2), the hippocampus of Tg(CAT) showed an increased resistance against OGD compared to that of wild-type (WT) animals.	Water	19-24	catalase	Mus musculus	48-55
21970067-5	2011	In addition to the two conventional enzymes, catalase and glutathione peroxidase, peroxiredoxins remove intracellular hydrogen peroxide by reducing it to water.	Water	154-159	catalase	Homo sapiens	45-53
21586817-1	2011	Fe(3)O(4) nanoparticles covalently linked to a gold electrode have been used for immobilizing catalase (CAT) enzyme to sense the presence of various concentrations of H(2)O(2).	Water	167-172	catalase	Homo sapiens	104-107
21586817-1	2011	Fe(3)O(4) nanoparticles covalently linked to a gold electrode have been used for immobilizing catalase (CAT) enzyme to sense the presence of various concentrations of H(2)O(2).	Water	167-172	catalase	Homo sapiens	94-102
21623439-2	2011	Here, we report a one-pot synthesis of doxorubicin-doped silica nanoparticles (Dox/SiNPs) by using sodium fluoride (NaF) catalyzed hydrolysis of tetraethyl orthosilicate in a water-in-oil microemulsion.	Water	175-180	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
22152237-5	2011	PSG dropped from (30.44+/-7.68) cm H2O to (18.78+/-4.71) cm H2O, mean portal pressure declined from (38.22+/-7.40) cm H2O to (27.00+/-5.38) cm H2O (P is less than 0.01).	Water	35-38	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	0-3
21725419-1	2011	For underwater image restoration, modeling of PSF relies on a priori knowledge of the inherent optical properties under water.	Water	9-14	insulin like growth factor binding protein 7	Homo sapiens	46-49
21621032-7	2011	To ensure the good selectivity to detect H(2)O(2), its determination was performed in a differential mode, with selective destruction of the H(2)O(2) with catalase in 10 mmolL(-1) phosphate buffer solution.	Water	41-46	catalase	Homo sapiens	155-163
21621032-7	2011	To ensure the good selectivity to detect H(2)O(2), its determination was performed in a differential mode, with selective destruction of the H(2)O(2) with catalase in 10 mmolL(-1) phosphate buffer solution.	Water	141-146	catalase	Homo sapiens	155-163
21574570-7	2011	Despite the apparently greater ease of access of water to the interior of hCYB5B than of rCYB5B suggested by these observations, the two proteins exhibit virtually identical stability, dynamic, and redox properties.	Water	49-54	cytochrome b5 type B	Homo sapiens	74-80
21574583-1	2011	We have directly observed the ring formation of colloidal particles of 1 mum diameter at the contact lines of air, water, and oil using a laser scanning confocal microscope.	Water	115-120	latexin	Homo sapiens	73-76
21813514-12	2011	Furthermore, the motive force for water flow should vary by 6.64-fold among nodes to compensate for the favored distribution of K(BP), which is an unrealistic value.	Water	34-39	kinesin family binding protein	Homo sapiens	128-133
21574570-5	2011	In a 10 ns molecular dynamics simulation, one of the buried water molecules in the hCYB5B structure exchanged readily with solvent via intermediates having three water molecules sandwiched between beta4 and beta5.	Water	60-65	cytochrome b5 type B	Homo sapiens	83-89
21574570-5	2011	In a 10 ns molecular dynamics simulation, one of the buried water molecules in the hCYB5B structure exchanged readily with solvent via intermediates having three water molecules sandwiched between beta4 and beta5.	Water	60-65	adaptor related protein complex 4 subunit beta 1	Homo sapiens	197-202
21574570-5	2011	In a 10 ns molecular dynamics simulation, one of the buried water molecules in the hCYB5B structure exchanged readily with solvent via intermediates having three water molecules sandwiched between beta4 and beta5.	Water	162-167	cytochrome b5 type B	Homo sapiens	83-89
21574570-6	2011	When the buried water molecules were removed prior to a second 10 ns simulation, beta4 and beta5 formed persistent hydrogen bonds identical to those in rCYB5B, but the Leu21 side chain was forced to adopt a rarely observed conformation.	Water	16-21	adaptor related protein complex 4 subunit beta 1	Homo sapiens	81-86
21438534-1	2011	We follow the evolution of the H(2)O/CO(2) interface at 300 K from the low pressure limit to near-critical pressures in molecular dynamics simulations using the SPC water and EPM2 carbon dioxide models.	Water	31-36	proline rich protein gene cluster	Homo sapiens	161-164
21612934-4	2011	Here, we evaluated the self-assembly pathways of Abeta(E22Delta) mutants generated from water-soluble, non-aggregative O-acyl isopeptide precursors.	Water	88-93	amyloid beta precursor protein	Homo sapiens	49-63
22152237-5	2011	PSG dropped from (30.44+/-7.68) cm H2O to (18.78+/-4.71) cm H2O, mean portal pressure declined from (38.22+/-7.40) cm H2O to (27.00+/-5.38) cm H2O (P is less than 0.01).	Water	60-63	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	0-3
22152237-5	2011	PSG dropped from (30.44+/-7.68) cm H2O to (18.78+/-4.71) cm H2O, mean portal pressure declined from (38.22+/-7.40) cm H2O to (27.00+/-5.38) cm H2O (P is less than 0.01).	Water	60-63	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	0-3
22152237-5	2011	PSG dropped from (30.44+/-7.68) cm H2O to (18.78+/-4.71) cm H2O, mean portal pressure declined from (38.22+/-7.40) cm H2O to (27.00+/-5.38) cm H2O (P is less than 0.01).	Water	60-63	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	0-3
21557566-1	2011	The reaction of VOSO(4) with 2-carboxyethylphosphonic acid (H(2)-CEP) in presence of piperazine (PIP) produces a 3D inorganic-organic hybrid framework, {(H(2)PIP)(0.5)[VO(CEP)] H(2)O} (1) with bidirectional channels occupied by the H(2)PIP cations and H(2)O molecules.	Water	177-182	prolactin induced protein	Homo sapiens	97-100
21532393-5	2011	Centrally injected NKB inhibited peripherally injected angiotensin II-induced water intake.	Water	78-83	angiotensinogen	Rattus norvegicus	55-69
21528854-2	2011	The further processability of the obtained water-soluble BNC including PEG lipid micelles and their use in bioconjugation experiments has been successfully demonstrated by covalently binding to bovine serum albumin (BSA).	Water	43-48	albumin	Homo sapiens	201-214
21557566-3	2011	The dehydrated framework, {(H(2)PIP)(0.5)[VO(CEP)]} (1") shows selective and gated adsorption behavior with H(2)O but not with methanol and ethanol.	Water	108-113	prolactin induced protein	Homo sapiens	32-35
21441309-6	2011	Removal of H(2)O(2) with catalase reduced flow-induced dilation in all groups, whereas Tempol diminished vasodilation in intact and OVE, but not OVX, rats.	Water	11-16	catalase	Rattus norvegicus	25-33
21135872-4	2011	Here, we report that aquaporin3 (AQP3) is a sperm water channel in mice and humans.	Water	50-55	aquaporin 3	Mus musculus	21-31
21135872-4	2011	Here, we report that aquaporin3 (AQP3) is a sperm water channel in mice and humans.	Water	50-55	aquaporin 3	Mus musculus	33-37
21553909-6	2011	Comparison of the phase diagrams of water models with the region of liquid-state anomalies shows that the crystalline phases are much more sensitive to the choice of water models than the liquid state anomalies; for example, SPC/E and TIP4P/2005 show qualitatively similar liquid state anomalies but very different phase diagrams.	Water	36-41	proline rich protein gene cluster	Homo sapiens	225-228
21553909-6	2011	Comparison of the phase diagrams of water models with the region of liquid-state anomalies shows that the crystalline phases are much more sensitive to the choice of water models than the liquid state anomalies; for example, SPC/E and TIP4P/2005 show qualitatively similar liquid state anomalies but very different phase diagrams.	Water	166-171	proline rich protein gene cluster	Homo sapiens	225-228
21083420-1	2011	To test the hypothesis that the inducible nitric oxide synthase (iNOS) is involved in mediating the toll-like receptor 4-dependent effects on the liver in the onset of fructose-induced steatosis, wild-type and iNOS knockout (iNOS(-/-)) mice were either fed tap water or 30% fructose solution for 8 weeks.	Water	261-266	nitric oxide synthase 2, inducible	Mus musculus	65-69
21838142-3	2011	Results show harmine in form of base and salt in water and in mixture of DMSO and water has the hightest inhibition activity on ACHE using eserine as reference substance.	Water	49-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
21838142-3	2011	Results show harmine in form of base and salt in water and in mixture of DMSO and water has the hightest inhibition activity on ACHE using eserine as reference substance.	Water	82-87	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
21042928-2	2011	The total concentration of PCB congeners ranged from 1.1 to 14 ng/l in water and 0.26-9.7 ng/g dry weight (dw) in sediment.	Water	71-76	pyruvate carboxylase	Homo sapiens	27-30
21591892-4	2011	Activation of the expression of human fibroblast growth factor 1 (HFGF1) after EMF exposure showed that molecular wound healing pathways are activated in response to this water-resonant EMF.	Water	171-176	fibroblast growth factor 1	Homo sapiens	38-64
21042928-3	2011	The results of seasonal variation may suggest an impact to PCB concentration in water from its atmospheric input, the dilution to PCBs concentrations of high stream in summer, and a general trend towards increased volatilization in warmer conditions.	Water	80-85	pyruvate carboxylase	Homo sapiens	59-62
21373963-0	2011	Water flux through human aquaporin 1: inhibition by intracellular furosemide and maximal response with high osmotic gradients.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	25-36
21384402-10	2011	Brain water content and locomotor activity normalized after AST-120 treatments, whereas arterial reactive oxygen species levels remained unchanged.	Water	6-11	solute carrier family 17 member 5	Homo sapiens	60-63
21373963-1	2011	This work studies water permeability properties of human aquaporin 1 (hAQP1) expressed in Xenopus laevis oocyte membranes, applying a technique where cellular content is replaced with a known medium, with the possibility of measuring intracellular pressure.	Water	18-23	aquaporin 1 (Colton blood group)	Homo sapiens	57-68
21373963-1	2011	This work studies water permeability properties of human aquaporin 1 (hAQP1) expressed in Xenopus laevis oocyte membranes, applying a technique where cellular content is replaced with a known medium, with the possibility of measuring intracellular pressure.	Water	18-23	aquaporin 1 (Colton blood group)	Homo sapiens	70-75
21373963-5	2011	These results would indicate that the passage of water molecules through hAQP1 may have a maximum rate.	Water	49-54	aquaporin 1 (Colton blood group)	Homo sapiens	73-78
21548825-3	2011	Lixivaptan is a selective vasopressin type 2 (V(2)) receptor antagonist that has been demonstrated to have the ability to induce aquaresis, the electrolyte sparing excretion of water, resulting in fluid removal as well as correction of hyponatremia.	Water	177-182	arginine vasopressin	Homo sapiens	26-37
21622200-3	2011	Aquaporin-8 (AQP8), localized to canalicular membranes, modulates membrane water permeability providing a molecular mechanism for the osmotically-coupled transport of solute and water during bile formation.	Water	75-80	aquaporin 8	Homo sapiens	0-11
21622200-3	2011	Aquaporin-8 (AQP8), localized to canalicular membranes, modulates membrane water permeability providing a molecular mechanism for the osmotically-coupled transport of solute and water during bile formation.	Water	75-80	aquaporin 8	Homo sapiens	13-17
21622200-3	2011	Aquaporin-8 (AQP8), localized to canalicular membranes, modulates membrane water permeability providing a molecular mechanism for the osmotically-coupled transport of solute and water during bile formation.	Water	178-183	aquaporin 8	Homo sapiens	0-11
21622200-3	2011	Aquaporin-8 (AQP8), localized to canalicular membranes, modulates membrane water permeability providing a molecular mechanism for the osmotically-coupled transport of solute and water during bile formation.	Water	178-183	aquaporin 8	Homo sapiens	13-17
21622200-6	2011	Moreover, AQP8 gene silencing in the human hepatocyte-derived cell line HepG2 inhibits canalicular water secretion.	Water	99-104	aquaporin 8	Homo sapiens	10-14
21622200-7	2011	Based on current knowledge, it is conceivable that cholestasis results from a mutual occurrence of impaired solute transport and AQP8-mediated decrease of canalicular water permeability.	Water	167-172	aquaporin 8	Homo sapiens	129-133
21384402-12	2011	CONCLUSION: AST-120 treatment decreased arterial ammonia levels, normalized brain water content and locomotor activity but did not demonstrate an effect on systemic oxidative stress.	Water	82-87	solute carrier family 17 member 5	Homo sapiens	12-15
21412242-1	2011	Angiotensin (Ang) II, the main effector peptide of the renin-Ang system, increases arterial blood pressure through Ang II type 1A (AT(1a)) receptor-dependent arterial vasoconstriction and by decreasing renal salt and water excretion through extrarenal and intrarenal mechanisms.	Water	217-222	angiotensinogen	Homo sapiens	0-20
21455711-5	2011	On February 26, nine water samples were taken from the hotel facilities used by the patient: In the hot tub sample 37,000 colony-forming units of P. aeruginosa/100 ml were detected.	Water	21-26	TUB bipartite transcription factor	Homo sapiens	104-107
21590807-5	2011	Photoreceptor degeneration in rd1 retina was apparent by decreased retinal thickness and loss of water diffusion anisotropy in both 1- and 3-month-old rd1 mice.	Water	97-102	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	30-33
21440898-8	2011	The high uptake capability and good stability of the Fe-Zr binary oxide make it a potentially attractive adsorbent for the removal of both As(V) and As(III) from water.	Water	162-167	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	139-144
21479636-3	2011	In this study, the attachment of anti-alpha-fetoprotein monoclonal antibody to a SAMs surface of 11-mercaptoundecanoic acid was achieved using water-soluble N-ethyl-N"-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide as coupling agents.	Water	143-148	alpha fetoprotein	Homo sapiens	38-55
21776218-3	2011	We found that expression of tumor necrosis factor-alpha (TNF-alpha), which activates both inflammation and NF-kappaB-dependent survival pathways, was strongly associated with water and urinary arsenic levels.	Water	175-180	tumor necrosis factor	Homo sapiens	28-55
21776218-3	2011	We found that expression of tumor necrosis factor-alpha (TNF-alpha), which activates both inflammation and NF-kappaB-dependent survival pathways, was strongly associated with water and urinary arsenic levels.	Water	175-180	tumor necrosis factor	Homo sapiens	57-66
21776218-3	2011	We found that expression of tumor necrosis factor-alpha (TNF-alpha), which activates both inflammation and NF-kappaB-dependent survival pathways, was strongly associated with water and urinary arsenic levels.	Water	175-180	nuclear factor kappa B subunit 1	Homo sapiens	107-116
21776218-4	2011	Expression of KCNA5, which encodes a potassium ion channel protein, was positively associated with water and toe nail arsenic levels.	Water	99-104	potassium voltage-gated channel subfamily A member 5	Homo sapiens	14-19
21590807-5	2011	Photoreceptor degeneration in rd1 retina was apparent by decreased retinal thickness and loss of water diffusion anisotropy in both 1- and 3-month-old rd1 mice.	Water	97-102	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	151-154
22164484-1	2011	OBJECTIVE: To explore the relationship between the Oncomelania snail situation and the distance to the water source, soil humidity, vegetation and water level in flood seasons in the islets of Changsha Section of the Xiang River.	Water	103-108	snail family transcriptional repressor 1	Homo sapiens	63-68
21557328-3	2011	TGFalpha-dependent ERK oscillations mediated through the epidermal growth factor receptor (EGFR) are inhibited by low dose X-irradiation (10 cGy) and low concentrations of hydrogen peroxide (0.32-3.26 microM H(2)O(2)) used as a model reactive oxygen species (ROS).	Water	208-213	mitogen-activated protein kinase 1	Homo sapiens	19-22
21557328-3	2011	TGFalpha-dependent ERK oscillations mediated through the epidermal growth factor receptor (EGFR) are inhibited by low dose X-irradiation (10 cGy) and low concentrations of hydrogen peroxide (0.32-3.26 microM H(2)O(2)) used as a model reactive oxygen species (ROS).	Water	208-213	epidermal growth factor receptor	Homo sapiens	57-89
21557328-3	2011	TGFalpha-dependent ERK oscillations mediated through the epidermal growth factor receptor (EGFR) are inhibited by low dose X-irradiation (10 cGy) and low concentrations of hydrogen peroxide (0.32-3.26 microM H(2)O(2)) used as a model reactive oxygen species (ROS).	Water	208-213	epidermal growth factor receptor	Homo sapiens	91-95
21376373-3	2011	Here we investigated the possible involvement of sGC, NO, plasminogen activator inhibitor (PAI-1) and p38 MAP Kinase in antithrombotic effects of CO released by a novel, water-soluble, CO releasing molecule-3 (CORM-3) using rat.	Water	170-175	serpin family E member 1	Rattus norvegicus	91-96
22164484-3	2011	The relationship between the snail density and the water level in blood seasons was analyzed.	Water	51-56	snail family transcriptional repressor 1	Homo sapiens	29-34
22164484-5	2011	There was an obvious positive correlation between the snail density and water level in flood seasons.	Water	72-77	snail family transcriptional repressor 1	Homo sapiens	54-59
22164484-7	2011	The map of snail situation by year was drawn according to the standard water level, which reflected the snail situation intuitionistically.	Water	71-76	snail family transcriptional repressor 1	Homo sapiens	11-16
22164484-7	2011	The map of snail situation by year was drawn according to the standard water level, which reflected the snail situation intuitionistically.	Water	71-76	snail family transcriptional repressor 1	Homo sapiens	104-109
22164484-9	2011	Even under the circumstance of human intervention, the water level in flood seasons is still an important factor influencing the change of snail situation.	Water	55-60	snail family transcriptional repressor 1	Homo sapiens	139-144
21330657-6	2011	EAU was induced in wild-type (WT) mice and in mice lacking IL-6 (IL-6KO), IL-17 (IL-17KO), and IFN-gamma (GKO) on a C57BL/6 background.	Water	0-3	interleukin 6	Mus musculus	59-63
21491854-3	2011	Interfacial rheology showed that fibrinogen has a low dilatational modulus at the air-water interface when compared to other proteins, suggesting the formation of a weak surface network.	Water	86-91	fibrinogen beta chain	Homo sapiens	33-43
21491854-4	2011	Fluorinated and hydrogenated surfactants severely decreased the dilatational modulus of the adsorbed fibrinogen film at the air-water interface.	Water	128-133	fibrinogen beta chain	Homo sapiens	101-111
21491854-5	2011	These measurements suggest the progressive displacement of fibrinogen from the air-water interface by both types of surfactants.	Water	83-88	fibrinogen beta chain	Homo sapiens	59-69
21460218-0	2011	Role of bulk water in hydrolysis of the rhodopsin chromophore.	Water	13-18	rhodopsin	Homo sapiens	40-49
21330657-8	2011	To study the roles of Treg cells, EAU was induced in IL-6KO mice treated with anti-CD25 monoclonal antibody (mAb) to deplete Treg cells in vivo.	Water	34-37	interleukin 6	Mus musculus	53-59
21513289-14	2011	The self-diffusion coefficients of water D(H(2)O) in PIM samples were found to be 1 order of magnitude higher than the value of D(I(-)) and varied slightly depending upon the plasticizer present in the membrane.	Water	35-40	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	53-56
21330657-13	2011	Treg cell depletion in vivo induced EAU in IL-6KO mice.	Water	36-39	interleukin 6	Mus musculus	43-49
21482270-7	2011	The sensors were applied to Cd(II) and Pb(II) determination in a certified lake-water sample.	Water	80-85	submaxillary gland androgen regulated protein 3B	Homo sapiens	39-45
21506575-5	2011	Lysozyme was crystallized in-meso from three common LLC phases (lamellar, inverse hexagonal, and inverse bicontinuous cubic) composed of monolinolein and water.	Water	154-159	lysozyme	Homo sapiens	0-8
21502813-1	2011	Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins that allow the movement of water and other small solutes, especially glycerol, through cell membranes.	Water	110-115	aquaporin 9	Homo sapiens	31-35
21373697-2	2011	The copper(II)-XO ensemble was highly selective for thiol species such as cysteine, homocysteine, and glutathione without interference from other amino acids and could quantitatively detect thiol in the range from 10 to 200 muM with a linear relationship having an average molar absorbance constant of 6530 L mol(-1) cm(-1) in pure water.	Water	332-337	latexin	Homo sapiens	224-227
21325494-1	2011	ANG II plays a major role in renal water and sodium regulation.	Water	35-40	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
21406187-5	2011	Acutely (2-4 days), HD also reduced water intake to icv ANG II (3.3+-2.2 vs. sham: 14.2+-3.0 ml/60 min) or carbachol (4.4+-1.8 vs. sham: 11.4+-1.6 ml/60 min); however, chronically (15-17 days), HD produced no change on ANG II- and carbachol-induced water intake, in spite of the increased daily water intake and urinary volume.	Water	36-41	angiotensinogen	Rattus norvegicus	56-62
21754320-3	2011	The Co(II) atom is in an almost octa-hedral environment formed by four carboxyl-ate O atoms from two malonate ligands and two water O atoms.	Water	126-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21456602-6	2011	Furthermore, in a fluoride concentration typical for tap water (10 muM), we observed roughening of individual step lines, resulting in the formation of scalloped morphologies.	Water	57-62	latexin	Homo sapiens	67-70
21473574-0	2011	In situ measurement of PCB pore water concentration profiles in activated carbon-amended sediment using passive samplers.	Water	32-37	pyruvate carboxylase	Homo sapiens	23-26
21786694-5	2011	The mobility was different but hindered by tens of times in all sites as compared with the rotation of K-35 in water.	Water	111-116	keratin 35	Homo sapiens	103-107
21376367-7	2011	However, the addition of dissolved Fe(III) species at 2.0 muM accelerated the light-induced degradation of phthalic acid by 3.5 times in the atmospheric water samples.	Water	153-158	latexin	Homo sapiens	58-61
21439408-7	2011	The structural differences in two distinct membrane-mimicking environments show that the micelle-bound VIP-G localized at the water-micelle boundary with these side chains toward micelle interior.	Water	126-131	vasoactive intestinal peptide	Homo sapiens	103-106
21615989-2	2011	Water-soluble extract of S. aureus cell lysate strongly induced human interleukin- 8 in human mast cell line-1 and mouse interleukin-6 in mouse bone marrow-derived mast cells.	Water	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	70-84
21615989-2	2011	Water-soluble extract of S. aureus cell lysate strongly induced human interleukin- 8 in human mast cell line-1 and mouse interleukin-6 in mouse bone marrow-derived mast cells.	Water	0-5	interleukin 6	Mus musculus	121-134
20369314-5	2011	Control rats consumed tap water.	Water	26-31	nuclear RNA export factor 1	Rattus norvegicus	22-25
21349311-10	2011	The procedure was successfully applied to the determination of trace levels of allura red in tap water and waste water samples.	Water	97-102	USO1 vesicle transport factor	Homo sapiens	93-96
21367924-1	2011	BACKGROUND: The water deprivation test (WDT) with direct or indirect measurement of plasma arginine vasopressin (AVP) is the method of choice for the differential diagnosis of the polydipsia-polyuria syndrome.	Water	16-21	arginine vasopressin	Homo sapiens	100-111
21367924-1	2011	BACKGROUND: The water deprivation test (WDT) with direct or indirect measurement of plasma arginine vasopressin (AVP) is the method of choice for the differential diagnosis of the polydipsia-polyuria syndrome.	Water	16-21	arginine vasopressin	Homo sapiens	113-116
21091382-5	2011	In water, the unimers assembled spontaneously in 20 nm size micelles with 60 muM critical micelle concentration.	Water	3-8	latexin	Homo sapiens	77-80
21923421-6	2011	Body water content and plasma osmolality are tightly regulated by the action of arginine vasopressin on renal tubules.	Water	5-10	arginine vasopressin	Homo sapiens	89-100
21473951-0	2011	Protective immunity conferred by a DNA adenine methylase deficient Salmonella enterica serovar Typhimurium vaccine when delivered in-water to sheep challenged with Salmonella enterica serovar Typhimurium.	Water	133-138	DNA adenine methylase	Salmonella enterica subsp. enterica serovar Typhimurium	35-56
21845871-6	2011	In model group and control with sterile water for injection group, the level of Bcl-2, Bax expression peaked at 3 d after hypoxic-ischemic brain damage (HIBD) (P &lt; 0.05 vs other groups), the value of neuronal density (ND) was decreased, and histological grade (HG) was increased compared with that in the sham group (P &lt; 0.05).	Water	40-45	BCL2, apoptosis regulator	Rattus norvegicus	80-85
21845871-7	2011	Breviscapine injection group, compared with control with sterile water for injection group, the expression of Bcl-2 protein was further increased, IOD value increased, while the expression of Bax protein was decreased, IOD value decreased, the value of ND increased, and HG decreased.	Water	65-70	BCL2, apoptosis regulator	Rattus norvegicus	110-115
21497778-6	2011	The RW-culture medium significantly depressed TNF-alpha-enhanced endothelial H(2)O(2) production; improved CX3CL1, ICAM-1, and p53 expression; and inhibited activated monocyte adhesion to endothelial cells as well as to the CX3CL1 or the ICAM-1 coated plate when compared with the distilled-water-culture medium.	Water	291-296	tumor necrosis factor	Rattus norvegicus	46-55
21425773-3	2011	Here, we report on the synthesis of new water-soluble, stable, fluorescent Ag clusters via a facile, green method using denatured bovine serum albumin (dBSA) as a stabilizing agent.	Water	40-45	albumin	Homo sapiens	137-150
21365101-1	2011	In our pursuit of an efficient, protecting-group-free synthesis of the dual CCK1/CCK2 receptor antagonist 1, we have developed chemoselective conditions for sulfonamide formation reaction in pure water and a PhNMe(2) mediated carboxamide formation, both in the presence of a carboxylic acid.	Water	196-201	C-C motif chemokine ligand 28	Homo sapiens	76-80
21376985-5	2011	Under optimal conditions, the cathodic peak currents of the electrochemical immunosensor were proportional to the logarithm of CEA concentration over the range from 0.01 to 12 ng mL(-1) in pH 5.5 HAc-NaAc containing 5mM H(2)O(2).	Water	220-225	CEA cell adhesion molecule 3	Homo sapiens	127-130
21306722-3	2011	When used as adsorbents, both PoPD hollow and solid sub-microspheres showed high adsorptivity and adsorption capacity towards Pb(II) ions in water, and mechanisms of adsorption behaviors were revealed by XRD and X-ray photoelectron spectra (XPS).	Water	141-146	submaxillary gland androgen regulated protein 3B	Homo sapiens	126-132
21359324-1	2011	The pH-dependent electrochemical behavior for a Co(II) complex, [Co(Py5)(OH(2))](ClO(4))(2) (1; Py5 = 2,6-(bis(bis-2-pyridyl)methoxymethane)pyridine), indicates consecutive (proton-coupled) oxidation steps furnish a Co(IV) species that catalyzes the oxidation of water in basic media.	Water	263-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
21416515-3	2011	Here we report the exchange rates of water ligated to Co(II) atoms in two polyoxotungstate sandwich molecules using the (17)O-NMR-based Swift-Connick method.	Water	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
21334314-2	2011	AQP4 has the highest water permeability and it is involved in hearing and vision in mammals.	Water	21-26	aquaporin 4	Danio rerio	0-4
21438627-0	2011	Colorimetric assays for acetylcholinesterase activity and inhibitor screening based on the disassembly-assembly of a water-soluble polythiophene derivative.	Water	117-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	24-44
21281609-4	2011	However, only ANGII induced significant water intake and increased sodium preference.	Water	40-45	angiotensinogen	Rattus norvegicus	14-19
21225336-7	2011	In the water-soluble tetrazolium salt (WST-1) assay, SNAI1 siRNA inhibited the proliferation of U87-MG and GBM05 glioblastoma cells.	Water	7-12	snail family transcriptional repressor 1	Homo sapiens	53-58
21217061-6	2011	High-glucose-induced upregulation of NQO1, GCLC, and HMOX1 was also prevented by pretreatment with polyethylene glycol (PEG)-catalase or N-acetylcysteine, whereas administration of H(2)O(2) mimicked the effect of high glucose.	Water	181-186	heme oxygenase 1	Mus musculus	53-58
21395877-6	2011	RESULTS: Budesonide and dexamethasone produced a concentration-dependent inhibition of the LPS-induced IL-8 and TNF-alpha secretion with an E(max) about 90% of inhibition, which was reduced by approximately 30% in the presence of H(2)O(2) or CSE.	Water	230-235	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
20646084-11	2011	Our findings indicate that subjects with the A transition at position -308 on the TNF-alpha gene experience more intense NSI with common ingredients, i.e., lactic acid and water, than those with the wild type.	Water	172-177	tumor necrosis factor	Homo sapiens	82-91
21195120-5	2011	Using various reactive oxygen scavengers, we found that catalase and sodium azide effectively inhibited GABA-tea extract/Cu(II)-induced DNA degradation, suggesting the essential role of singlet oxygen and H(2)O(2) in the reaction.	Water	205-210	catalase	Homo sapiens	56-64
20556645-6	2011	Excluding the well data, total PCB concentrations in raw water at systems in the Upper River were similar to concentrations at systems in the Lower River, though the congener patterns differed.	Water	57-62	pyruvate carboxylase	Homo sapiens	31-34
21336227-6	2011	An average of nearly 1 mug of DMPC was eluted into ATF within the first 10 h. Elution was about five times faster in ATF than in water.	Water	129-134	glial cell derived neurotrophic factor	Homo sapiens	51-54
21360438-1	2011	Aquaporin-1 (AQP1) is the main water channel responsible for water transport through many epithelia and endothelia.	Water	31-36	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
21360438-1	2011	Aquaporin-1 (AQP1) is the main water channel responsible for water transport through many epithelia and endothelia.	Water	31-36	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
21360438-1	2011	Aquaporin-1 (AQP1) is the main water channel responsible for water transport through many epithelia and endothelia.	Water	61-66	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
21360438-1	2011	Aquaporin-1 (AQP1) is the main water channel responsible for water transport through many epithelia and endothelia.	Water	61-66	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
21702337-2	2011	This report covers the activity of 10 types of hot water extracts of coffee on human tissue-type plasminogen activator producing cells.	Water	51-56	plasminogen activator, tissue type	Homo sapiens	85-118
25587250-4	2011	The experimental groups after pregnancy received an oral dose of 0.05 mg/ml of morphine by tap water while the control group received only tap water.	Water	95-100	nuclear RNA export factor 1	Rattus norvegicus	91-94
21289257-8	2011	Median plasma copeptin concentrations decreased from 3.3 (1.1-36.4) pm at baseline to 2.0 (0.9-10.4) pm after water load and increased to 13.6 (3.7-43.3) pm after hypertonic saline.	Water	110-115	arginine vasopressin	Homo sapiens	14-22
21443715-4	2011	We previously reported that postprandial water intake inhibits gastric antral motility along with an increase of cholecystokinin (CCK) in normal subjects.	Water	41-46	cholecystokinin	Homo sapiens	113-128
21443715-4	2011	We previously reported that postprandial water intake inhibits gastric antral motility along with an increase of cholecystokinin (CCK) in normal subjects.	Water	41-46	cholecystokinin	Homo sapiens	130-133
21443715-5	2011	We assumed that the rapid increase of CCK after water intake was initiated by a feedback mechanism related to the inflow of fatty chyme into the duodenum that inhibits gastric antral activity.	Water	48-53	cholecystokinin	Homo sapiens	38-41
21556222-7	2011	The water fraction of hawthorn fruit was determined to be safe and significantly inhibited NO production in LPS-stimulated RAW 264.7 cells and suppressed COX-2, TNF-alpha, IL-1beta, and IL-6 expression.	Water	4-9	tumor necrosis factor	Mus musculus	161-170
21556222-7	2011	The water fraction of hawthorn fruit was determined to be safe and significantly inhibited NO production in LPS-stimulated RAW 264.7 cells and suppressed COX-2, TNF-alpha, IL-1beta, and IL-6 expression.	Water	4-9	interleukin 1 beta	Mus musculus	172-180
21556222-7	2011	The water fraction of hawthorn fruit was determined to be safe and significantly inhibited NO production in LPS-stimulated RAW 264.7 cells and suppressed COX-2, TNF-alpha, IL-1beta, and IL-6 expression.	Water	4-9	interleukin 6	Mus musculus	186-190
21556222-8	2011	The observed anti-inflammatory effects of the water fraction of hawthorn fruit might be attributed to the down-regulation of COX-2, TNF-alpha, IL-1beta, and IL-6 expression in LPS-stimulated RAW 264.7 cells.	Water	46-51	tumor necrosis factor	Mus musculus	132-141
21556222-8	2011	The observed anti-inflammatory effects of the water fraction of hawthorn fruit might be attributed to the down-regulation of COX-2, TNF-alpha, IL-1beta, and IL-6 expression in LPS-stimulated RAW 264.7 cells.	Water	46-51	interleukin 1 beta	Mus musculus	143-151
21556222-8	2011	The observed anti-inflammatory effects of the water fraction of hawthorn fruit might be attributed to the down-regulation of COX-2, TNF-alpha, IL-1beta, and IL-6 expression in LPS-stimulated RAW 264.7 cells.	Water	46-51	interleukin 6	Mus musculus	157-161
21428665-1	2011	We have performed an atomistic molecular dynamics simulation of an aqueous solution of hen egg-white lysozyme at room temperature with explicit water molecules.	Water	144-149	lysozyme	Homo sapiens	101-109
20967843-1	2011	In cystic fibrosis (CF), CFTR dysfunction leads to salt and water imbalance across airway epithelia, depleted surface liquid layer, and impaired mucociliary clearance.	Water	60-65	CF transmembrane conductance regulator	Homo sapiens	25-29
21252236-0	2011	NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1.	Water	65-70	Ly6/neurotoxin 1	Homo sapiens	95-100
21252236-3	2011	We report for the first time the NMR spatial structure for the water-soluble domain of human LYNX1 lacking a GPI anchor (ws-LYNX1) and its concentration-dependent activity on nicotinic acetylcholine receptors (nAChRs).	Water	63-68	Ly6/neurotoxin 1	Homo sapiens	93-98
21252236-3	2011	We report for the first time the NMR spatial structure for the water-soluble domain of human LYNX1 lacking a GPI anchor (ws-LYNX1) and its concentration-dependent activity on nicotinic acetylcholine receptors (nAChRs).	Water	63-68	Ly6/neurotoxin 1	Homo sapiens	124-129
21528012-2	2011	The nonpolar lipids studied, cholesterol, 5alpha-cholestane, cholesta-3,5-diene, squalene, and beta-carotene, were found to solely form the desired water replacement product (adduct-H(2)O) with the ClMn(H(2)O)(+) ions.	Water	148-153	calmin	Homo sapiens	198-202
21255559-11	2011	Prenatal dehydration resulted in a significant increase in intracerebroventricular angiotensin II-induced water intake in male, but not female, offspring.	Water	106-111	angiotensinogen	Rattus norvegicus	83-97
21130866-8	2011	FasL up-regulation; activation of caspases-8, -2, -9, and -3; and chromatin condensation were decreased by the p53 inhibitor pifithrin-alpha, implicating p53 as an upstream factor in the activation of death receptor-mediated apoptosis by H(2)O(2).	Water	238-243	tumor protein p53	Homo sapiens	111-114
21292273-7	2011	It was also observed that ACE butyl and ACE phenyl columns retained basic compounds when the columns were eluted with a mobile phase consisting of acetonitrile/water (95:5) containing 3.25 mM ammonium acetate.	Water	160-165	angiotensin I converting enzyme	Homo sapiens	26-29
20724370-8	2011	On days 11 and 29, CLi increased (P &lt; 0.02) indicating a significant 10-16% decrease in absolute proximal reabsorption of sodium and water (APR = GFR - CLi, P &lt; 0.05).	Water	136-141	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	143-146
21130866-8	2011	FasL up-regulation; activation of caspases-8, -2, -9, and -3; and chromatin condensation were decreased by the p53 inhibitor pifithrin-alpha, implicating p53 as an upstream factor in the activation of death receptor-mediated apoptosis by H(2)O(2).	Water	238-243	tumor protein p53	Homo sapiens	154-157
21185943-6	2011	Significant decreases in water diffusion parallel to the white matter fibers or axial diffusivity were observed in the SOD1 mice, which can be attributed to the axonal degeneration observed by electron microscopy.	Water	25-30	superoxide dismutase 1, soluble	Mus musculus	119-123
21247694-11	2011	This promising result can provide a basis for applying the studied materials to the treatment of water effluents containing Co(II) chelated by EDTA by a simple one-step adsorption process.	Water	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
21268656-1	2011	A new water-soluble cryptophane 1 derivative (penta-hydroxyl cryptophane-A) has been synthesized from cryptophanol-A and the chiroptical properties of its two enantiomers MM-1 and PP-1 have been studied by polarimetry, electronic circular dichroism (ECD), and vibrational circular dichroism (VCD).	Water	6-11	inorganic pyrophosphatase 1	Homo sapiens	180-184
21234484-1	2011	A water-soluble covalently linked C(60)-porphyrin compound-C(60)Por is reported to show enhanced DNA-cleaving activity.	Water	2-7	cytochrome p450 oxidoreductase	Homo sapiens	64-67
21234484-2	2011	The highly enhanced DNA-cleaving activity is expected to be ascribed to the high water-solubility and affinity of C(60)Por to DNA, as well as to the accessibility to the charge-separated states C(60) (-)-Por (+) formed under radiation.	Water	81-86	cytochrome p450 oxidoreductase	Homo sapiens	119-122
21234484-2	2011	The highly enhanced DNA-cleaving activity is expected to be ascribed to the high water-solubility and affinity of C(60)Por to DNA, as well as to the accessibility to the charge-separated states C(60) (-)-Por (+) formed under radiation.	Water	81-86	cytochrome p450 oxidoreductase	Homo sapiens	204-207
21280635-5	2011	The reported experimental evidence shows that the peptide assumes in water a well-defined helical conformation and indicates that this peptide is a VEGF receptor antagonist and possesses antiangiogenic biological activity.	Water	69-74	vascular endothelial growth factor A	Homo sapiens	148-152
21225028-0	2011	Me2-NHC based robust Ir catalyst for efficient water oxidation.	Water	47-52	malic enzyme 2	Homo sapiens	0-3
21183974-5	2011	The possible mechanism of ion-exchange reaction may take place between the HCl salt of MCP H(2)O and a KBr matrix by grinding or heating to yield a mixture of HCl and HBr salts of the MCP sample in the presence of hydrated water.	Water	223-228	CD46 molecule	Homo sapiens	87-90
21183974-5	2011	The possible mechanism of ion-exchange reaction may take place between the HCl salt of MCP H(2)O and a KBr matrix by grinding or heating to yield a mixture of HCl and HBr salts of the MCP sample in the presence of hydrated water.	Water	223-228	CD46 molecule	Homo sapiens	184-187
21183974-6	2011	The crystal hydrate played an important role to improve this ion-exchange reaction between MCP H(2)O and KBr.	Water	95-100	CD46 molecule	Homo sapiens	91-94
21306127-5	2011	The sensitivity of our assay to detect Pb(II) level in water is almost 2 orders of magnitude higher than the EPA standard limit.	Water	55-60	submaxillary gland androgen regulated protein 3B	Homo sapiens	39-45
21299210-4	2011	The pumping of water is efficient: 13 000 water molecules are pumped per reacted electron and 4.8 mL of water are pumped per joule at a flow rate of 0.13 mL min(-1) V(-1) cm(-2), and a flow rate per unit of power is 290 mL min(-1) W(-1).	Water	15-20	CD59 molecule (CD59 blood group)	Homo sapiens	157-163
21299210-4	2011	The pumping of water is efficient: 13 000 water molecules are pumped per reacted electron and 4.8 mL of water are pumped per joule at a flow rate of 0.13 mL min(-1) V(-1) cm(-2), and a flow rate per unit of power is 290 mL min(-1) W(-1).	Water	15-20	CD59 molecule (CD59 blood group)	Homo sapiens	223-229
21306127-0	2011	Gold nanoparticle-based simple colorimetric and ultrasensitive dynamic light scattering assay for the selective detection of Pb(II) from paints, plastics, and water samples.	Water	159-164	submaxillary gland androgen regulated protein 3B	Homo sapiens	125-131
21359604-4	2011	First, the rate of water desorption during secondary drying at constant product temperatures (-22  C, -10  C, and 0  C) was investigated for three different shelf temperatures.	Water	19-24	Rho GTPase activating protein 9	Homo sapiens	93-118
21381643-2	2011	Anti-fog coatings are hydrophilic, enabling water to spread uniformly on the surface rather than form dispersed droplets.	Water	44-49	zinc finger protein, FOG family member 1	Homo sapiens	5-8
21381643-10	2011	The hydrophilic nature of the anti-fog coating was assessed by water contact angle (CA), and its anti-fog efficiency was determined visually and tested quantitatively for the first time using an ASTM standard protocol.	Water	63-68	zinc finger protein, FOG family member 1	Homo sapiens	35-38
21381643-12	2011	Finally, following a 24 hour immersion in water, these PEMA/PVA coatings remained stable and preserved their anti-fog properties.	Water	42-47	zinc finger protein, FOG family member 1	Homo sapiens	114-117
32938082-1	2011	ThO2 with approximately 3% 233UO2 is the proposed fuel for the Advanced Heavy Water Reactor (AHWR) and characterized as a mixed oxide (MOX) fuel.	Water	78-83	THO complex 2	Homo sapiens	0-4
21159737-9	2011	These results suggest that the increased expression of renal ENaC subunits may contribute to the renal sodium and water retention observed during CHF.	Water	114-119	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	61-65
21146631-8	2011	Since free oxidized cyt c acquired peroxidase activity towards H(2)O(2) upon interaction with CL in vitro, a contribution of cyt c to H(2)O(2) disposal in mitochondria through CL conferred peroxidase activity is plausible.	Water	63-68	cytochrome c, somatic	Homo sapiens	20-25
22235396-1	2011	New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10(-9)M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H(2)O(2)and glutamate.	Water	230-235	glycerol kinase 2	Mus musculus	38-42
21338791-10	2011	Primiparous cows benefited from water troughs located for easy access and responded with increased milk yield.	Water	32-37	Weaning weight-maternal milk	Bos taurus	99-103
21123038-0	2011	Micelles from PEO-PPO-PEO block copolymers as nanocontainers for solubilization of a poorly water soluble drug hydrochlorothiazide.	Water	92-97	protoporphyrinogen oxidase	Homo sapiens	18-21
21093977-2	2011	This paper describes a study of the spatial variability of human health risk (i.e., cancer effects) from CBP exposure through drinking water in a specific region.	Water	135-140	CREB binding protein	Homo sapiens	105-108
21338791-12	2011	Higher parities had increased milk yield when water trough capacity was more than 80%.	Water	46-51	Weaning weight-maternal milk	Bos taurus	30-34
21217100-7	2011	CME-1 reduced H(2)O(2) treatment-elevated C16- and C18-ceramide levels measured by LC/MS/MS in RAW264.7 cells.	Water	14-19	Bardet-Biedl syndrome 9	Homo sapiens	51-54
21675200-3	2011	The action of vasopressin on water permeability is counterbalanced by several factors such as prostaglandin E2, bradykinin, dopamin, endotelin-1 and others.	Water	29-34	arginine vasopressin	Homo sapiens	14-25
21259319-11	2011	In the presence of 30 muM Hg2+, which inhibits water movement through AQP1 and AQP9, the hypoosmolarity-induced water influxes were reduced.	Water	47-52	aquaporin 9	Rattus norvegicus	79-83
21259319-11	2011	In the presence of 30 muM Hg2+, which inhibits water movement through AQP1 and AQP9, the hypoosmolarity-induced water influxes were reduced.	Water	112-117	aquaporin 9	Rattus norvegicus	79-83
21517540-7	2011	Using nuclear magnetic resonance to measure the isotherms of lysozyme in situ between 18 and 2  C, the present work provides evidence that the part of water uptake associated with the onset of protein function is significantly reduced below 8  C. Quantitative analysis shows that such reduction is directly related to the reduction of protein flexibility and enhanced cost in elastic energy upon hydration at lower temperature.	Water	151-156	lysozyme	Homo sapiens	61-69
21208655-9	2011	Since preeclampsia is not known to be associated with an altered water flux to the fetus we propose that AQP9 might not have a key role in water transport in human placenta, but a function in the energy metabolism or the urea uptake and elimination across the placenta.	Water	139-144	aquaporin 9	Homo sapiens	105-109
21500553-6	2011	And comparing with HIBD group, the expressions of MIF, pERK1/2, MMP-9 and the water contents were decreased obviously in the anti-MIF group (P &lt; 0.05).	Water	78-83	macrophage migration inhibitory factor	Rattus norvegicus	130-133
21522293-1	2011	In the title diaqua-cobalt complex, [Co(C(8)H(11)NO(5)PS)(2)(H(2)O)(2)], the Co(II) atom is surrounded by six O atoms belonging to the phosphoryl and sulfonyl groups of two deprotonated chelate ligands and two additional O atoms from water mol-ecules which are in cis positions with respect to one another.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
21185908-4	2011	Around the ribbon synapses in this layer, AQP6 labeling was co-localized with the glial water channel AQP4.	Water	88-93	aquaporin 6	Rattus norvegicus	42-46
21186080-0	2011	Removal of As(III) and As(V) from water by copper oxide incorporated mesoporous alumina.	Water	34-39	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-28
21152621-0	2011	Combing DNAzyme with single-walled carbon nanotubes for detection of Pb(II) in water.	Water	79-84	submaxillary gland androgen regulated protein 3B	Homo sapiens	69-75
21212894-5	2011	The model also explains the striking difference between the value of water dipole mu~ 3D reported in recent ab initio and experimental studies with the value mu(eff)~ 2.3D typically used in the empirical potentials, such as TIP3P or SPC/E.	Water	69-74	proline rich protein gene cluster	Homo sapiens	233-236
21210672-2	2011	At room temperature, the native structure of cytochrome c is maintained in relatively high ionic liquid concentrations (50-70% AAF/water or AAF/phosphate buffer pH 7.0) in contrast with denaturation of cytochrome c in similar solutions of methanol or acetonitrile with water or buffer cosolvents.	Water	269-274	cytochrome c, somatic	Homo sapiens	45-57
21192636-5	2011	Imaging in different environments supports the expected hydration of the fibrinogen molecules in buffer, whereas imaging in humid air suggests the 2D spreading of fibrinogen on mica induced by an adsorbed water layer.	Water	205-210	fibrinogen beta chain	Homo sapiens	163-173
21210672-2	2011	At room temperature, the native structure of cytochrome c is maintained in relatively high ionic liquid concentrations (50-70% AAF/water or AAF/phosphate buffer pH 7.0) in contrast with denaturation of cytochrome c in similar solutions of methanol or acetonitrile with water or buffer cosolvents.	Water	131-136	cytochrome c, somatic	Homo sapiens	45-57
21210672-3	2011	Fluorescence and CD spectra indicate that the conformation of cytochrome c is maintained in 20% AAF-80% water from 30 to 50  C. No such temperature stability is found in 80% AAF-20% water.	Water	104-109	cytochrome c, somatic	Homo sapiens	62-74
21210672-3	2011	Fluorescence and CD spectra indicate that the conformation of cytochrome c is maintained in 20% AAF-80% water from 30 to 50  C. No such temperature stability is found in 80% AAF-20% water.	Water	182-187	cytochrome c, somatic	Homo sapiens	62-74
21210672-4	2011	About one-third of the enzyme activity of cytochrome c in 80% AAF-20% water can be maintained as compared with phosphate buffer, and this is greater than the activities measured in corresponding methanol and acetonitrile aqueous solutions.	Water	70-75	cytochrome c, somatic	Homo sapiens	42-54
21294856-6	2011	administration of 10 mug of EJHE and EJHE-water residue (WR), prepared from butanol extraction, increased significantly IFN-gamma production in the spleen (p &lt; 0.01) and lung (p &lt; 0.03) tissues at 6-48 hours and suppressed significantly TGF-beta1 production levels (p &lt; 0.001) in the spleen for as long as 48 hours.	Water	42-47	interferon gamma	Mus musculus	120-129
21347258-0	2011	Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice.	Water	61-66	matrix metallopeptidase 17	Mus musculus	0-40
21347258-0	2011	Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice.	Water	61-66	matrix metallopeptidase 17	Mus musculus	42-49
21347258-6	2011	However, MT4-MMP-null mice had decreased daily water intake and daily urine output, consistent with primary hypodipsia.	Water	47-52	matrix metallopeptidase 17	Mus musculus	9-16
21118806-2	2011	In this study, we examined the effect of the mutation of the NPC motif on the subcellular localization, oligomerization, and water permeability of AQP11 in transfected mammalian cells.	Water	125-130	aquaporin 11	Homo sapiens	147-152
21118806-5	2011	A cell swelling assay revealed that cells expressing AQP11 with a mutated NPC motif had significantly lower osmotic water permeability than cells expressing wild-type AQP11.	Water	116-121	aquaporin 11	Homo sapiens	53-58
21118806-8	2011	Although the NPA motif is known to be important for formation of water-permeable pores by conventional AQPs, our observations suggest that the corresponding NPC motif of AQP11 is essential for full expression of molecular function.	Water	65-70	aquaporin 11	Homo sapiens	170-175
21103538-7	2011	The frequencies of the C=C vibrational modes are consistent with a six-coordinated state of the POR-bound Pchlide, suggesting that there are two coordination interactions between the central Mg atom of the chromophore and protein residues, and/or a water molecule.	Water	249-254	cytochrome p450 oxidoreductase	Homo sapiens	96-99
21310091-5	2011	Analysis of the total phenolic content reveals that the water extract, with the best anti-PLA2 effect, was poor in phenolic molecules (2 mg GAE/g).	Water	56-61	phospholipase A2 group IB	Homo sapiens	90-94
21303091-0	2011	Sources of the deficiencies in the popular SPC/E and TIP3P models of water.	Water	69-74	proline rich protein gene cluster	Homo sapiens	43-46
21219380-1	2011	Aquaporin-9 (AQP-9) regulates tissue hydration by promoting transmembrane exchanges of both water and solutes, such as lactate.	Water	92-97	aquaporin 9	Homo sapiens	0-11
21166409-2	2011	Here we report a fluorescence resonance energy transfer (FRET) inhibition assay for alpha-fetoprotein (AFP) excreted during cancer cell growth using water-soluble functionalized PLNPs based on Eu2+- and Dy3+-doped Ca1.86Mg0.14ZnSi2O7.	Water	149-154	alpha fetoprotein	Homo sapiens	84-101
21166409-2	2011	Here we report a fluorescence resonance energy transfer (FRET) inhibition assay for alpha-fetoprotein (AFP) excreted during cancer cell growth using water-soluble functionalized PLNPs based on Eu2+- and Dy3+-doped Ca1.86Mg0.14ZnSi2O7.	Water	149-154	alpha fetoprotein	Homo sapiens	103-106
21219380-1	2011	Aquaporin-9 (AQP-9) regulates tissue hydration by promoting transmembrane exchanges of both water and solutes, such as lactate.	Water	92-97	aquaporin 9	Homo sapiens	13-18
21219380-9	2011	AQP-9 expression occurs in normal human testis, at cell membrane of primary spermatocytes and h-GCs, suggesting a possible role of AQP-9 in the water and lactate transport from Sertoli cells to GCs.	Water	144-149	aquaporin 9	Homo sapiens	0-5
21219380-9	2011	AQP-9 expression occurs in normal human testis, at cell membrane of primary spermatocytes and h-GCs, suggesting a possible role of AQP-9 in the water and lactate transport from Sertoli cells to GCs.	Water	144-149	aquaporin 9	Homo sapiens	131-136
21226463-1	2011	Electrogenerated chemiluminescence (ECL) emission was observed from the water-soluble, bovine serum albumin (BSA)-stabilized Au nanoclusters for the first time.	Water	72-77	albumin	Homo sapiens	94-107
21155863-0	2011	Renal epidermal growth factor receptor: its role in sodium and water homeostasis in diabetic nephropathy.	Water	63-68	epidermal growth factor receptor	Homo sapiens	6-38
20926064-1	2011	BACKGROUND AND OBJECTIVES: The epithelial sodium channel (ENaC) has a critical role in the control of sodium balance, blood volume, blood pressure and viscosity of extracellular water.	Water	178-183	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	58-62
21312319-2	2011	The aim of this study was to investigate the toxicity of organic extracts (OE) in tap water from the source of the Jialing River in China on the reproductive system of male mice.	Water	86-91	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	82-85
21510427-0	2011	[X-ray absorption spectroscopic evidence for the formation of Pb(II) inner-sphere adsorption complexes and precipitates at the alkaline soil-water interface].	Water	141-146	submaxillary gland androgen regulated protein 3B	Homo sapiens	62-68
21155863-7	2011	Enhanced sodium and water reabsorption, occurring as a consequence of endogenous or pharmacological stimulation of the peroxisome proliferator-activated receptor gamma is Sgk1 mediated.	Water	20-25	peroxisome proliferator activated receptor gamma	Homo sapiens	119-167
21155863-9	2011	EGFR inhibitors, which are currently used clinically to treat malignancies, might have potential in attenuating the cellular mechanisms responsible for thiazolidinedione (TZD)-mediated sodium and water transport in diabetes.	Water	196-201	epidermal growth factor receptor	Homo sapiens	0-4
21155863-11	2011	In the present review, the authors focus on the importance of the EGFR in sodium and water uptake in the proximal tubule in the environment of pathophysiological and pharmacological influences.	Water	85-90	epidermal growth factor receptor	Homo sapiens	66-70
21075044-1	2011	Redox cycling compounds (RCCs) generate muM concentrations of hydrogen peroxide (H(2)O(2)) in the presence of strong reducing agents, common buffer components used to maintain the catalytic activity and/or folding of target proteins for high throughput screening (HTS) assays.	Water	81-86	latexin	Homo sapiens	40-43
21270272-7	2011	Forced activation of Nrf2 by adenoviral over-expression of Nrf2 inhibited the increased ERK activity and recovered the blunted insulin sensitivity on glucose uptake in cardiomyocytes that were chronically treated with H(2)O(2).	Water	218-223	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
21270272-7	2011	Forced activation of Nrf2 by adenoviral over-expression of Nrf2 inhibited the increased ERK activity and recovered the blunted insulin sensitivity on glucose uptake in cardiomyocytes that were chronically treated with H(2)O(2).	Water	218-223	nuclear factor, erythroid derived 2, like 2	Mus musculus	59-63
21270272-7	2011	Forced activation of Nrf2 by adenoviral over-expression of Nrf2 inhibited the increased ERK activity and recovered the blunted insulin sensitivity on glucose uptake in cardiomyocytes that were chronically treated with H(2)O(2).	Water	218-223	mitogen-activated protein kinase 1	Mus musculus	88-91
21780702-10	2011	The method was applied successfully to the removal of As(III) and As(V) from drinking water, geothermal water and mineral water.	Water	86-91	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	66-71
21175868-0	2011	Inhibition of TNF-alpha induced-adhesion molecules by Avene Thermal Spring Water in human endothelial cells.	Water	75-80	tumor necrosis factor	Homo sapiens	14-23
21185297-1	2011	Arginine vasopressin (AVP) is involved in the homeostatic responses numerous life-threatening conditions, for example, the promotion of water conservation during periods of dehydration, and the activation of the hypothalamo-pituitary adrenal axis by emotional stress.	Water	136-141	arginine vasopressin	Rattus norvegicus	9-20
21142220-0	2011	An insight to conserved water molecular dynamics of catalytic and structural Zn(+2) ions in matrix metalloproteinase 13 of human.	Water	24-29	matrix metallopeptidase 13	Homo sapiens	92-119
21142220-2	2011	Water molecular dynamic studies of the five (1XUC, 1XUD, 1XUR, 456C, 830C) PDB and solvated structures of MMP-13 in human have been carried out upto 5 ns on assigning the differential charges (+2, +1, +0.5 e) to both the Zinc ions.	Water	0-5	matrix metallopeptidase 13	Homo sapiens	106-112
21142220-6	2011	So the hydrophilic topology and stereochemistry of water mediated coupling between Zn-ions may provide some plausible hope towards the design of some bidentate/polydentate bridging ligands or inhibitors for MMP-13.	Water	51-56	matrix metallopeptidase 13	Homo sapiens	207-213
21094969-6	2011	Pore water As(V) was detected at trace concentrations only.	Water	5-10	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	11-16
21364300-3	2011	Dex-GMA microspheres loaded with hIFN-alpha was then prepared by the water-in-water emulsion technique.	Water	69-74	interferon alpha 1	Homo sapiens	33-43
21194613-1	2011	We synthesized, characterized and studied the anticancer properties of a new water-soluble peroxo niobium complex (K(3)[Nb(Asc)(O(2))(3)] 4H(2)O (Asc = ascorbate anion C(6)H(6)O(6)(2-))), as well as that of ascorbic acid, in human leukemic cells.	Water	77-82	PYD and CARD domain containing	Homo sapiens	123-126
21194613-1	2011	We synthesized, characterized and studied the anticancer properties of a new water-soluble peroxo niobium complex (K(3)[Nb(Asc)(O(2))(3)] 4H(2)O (Asc = ascorbate anion C(6)H(6)O(6)(2-))), as well as that of ascorbic acid, in human leukemic cells.	Water	77-82	PYD and CARD domain containing	Homo sapiens	146-149
21364300-3	2011	Dex-GMA microspheres loaded with hIFN-alpha was then prepared by the water-in-water emulsion technique.	Water	78-83	interferon alpha 1	Homo sapiens	33-43
21354898-1	2011	OBJECTIVE: To investigate the effect of water extracts of Coptidis Rhizoma and Evodiae Fructus (CREF) on the proliferation and apoptosis of human gastric carcinoma cells (SGC-7901) and determine the optimal proportion of Coptidis rhizoma to Evodiae fructus.	Water	40-45	sarcoglycan beta	Homo sapiens	171-174
21354898-4	2011	RESULTS: The water extract of CREF with Coptidis Rhizoma: Evodiae Fructus proportions at 1:6, 2:5, 3:4, 4:3, 5:2, and 6:1 all significantly inhibited the growth of SGC-7901 cells after a 24-h or 48-h treatment (P&lt;0.05).	Water	13-18	sarcoglycan beta	Homo sapiens	164-167
21183538-6	2011	Catalase protected weakly p67(phox) from H(2)O(2).	Water	41-46	catalase	Homo sapiens	0-8
21186174-7	2011	However, the circadian oscillation in water dynamics was obscured in the early-flowering 3 (elf3) mutant under LL.	Water	38-43	hydroxyproline-rich glycoprotein family protein	Arabidopsis thaliana	92-96
21183538-6	2011	Catalase protected weakly p67(phox) from H(2)O(2).	Water	41-46	CD33 molecule	Homo sapiens	26-29
20734314-0	2011	Characterizing amyloid-beta protein misfolding from molecular dynamics simulations with explicit water.	Water	97-102	amyloid beta precursor protein	Homo sapiens	15-27
21476293-4	2011	Salusin-beta peptide adheres to polypropylene, glass and polystyrene, so that the aliquoted peptide dissolved in distilled water may rapidly disappear from the dissolved solution.	Water	123-128	torsin family 2 member A	Homo sapiens	0-12
22164385-14	2011	CONCLUSIONS: In hilly regions, the implementation of snail control project by environmental modification combined with construction of water conservancy is effective, and the cost-effectiveness of the snail control with digging new ditches to fill up the old ones is excellent.	Water	135-140	snail family transcriptional repressor 1	Homo sapiens	53-58
21369092-3	2011	The size of particles suspended in water for trapping is 2.08 mum in diameter and the wavelength of light used for inducing photothermal effect is 1.55 mum with a power of 97 mW.	Water	35-40	latexin	Homo sapiens	62-65
21141970-1	2011	Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water.	Water	182-187	cystathionine beta-synthase	Homo sapiens	29-32
21082090-0	2011	Water-driven ligations using cyclic amino squarates: a class of useful SN1-like reactions.	Water	0-5	solute carrier family 38 member 3	Homo sapiens	71-74
21084311-1	2011	The Ca(2+)-sensing receptor (CaR) regulates salt and water transport in the kidney as demonstrated by the association of gain of function CaR mutations with a Bartter syndrome-like, salt-wasting phenotype, but the precise mechanism for this effect is not fully established.	Water	53-58	calcium sensing receptor	Homo sapiens	4-27
21141970-1	2011	Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water.	Water	182-187	cystathionine beta-synthase	Homo sapiens	0-27
21084311-1	2011	The Ca(2+)-sensing receptor (CaR) regulates salt and water transport in the kidney as demonstrated by the association of gain of function CaR mutations with a Bartter syndrome-like, salt-wasting phenotype, but the precise mechanism for this effect is not fully established.	Water	53-58	calcium sensing receptor	Homo sapiens	29-32
20851146-1	2011	Chicks genetically selected for low juvenile body weight had a lower threshold of central insulin-induced decreased food and water intake and whole blood glucose concentration than those selected for juvenile high body weight.	Water	125-130	insulin	Homo sapiens	90-97
21116534-0	2011	Cyclophosphates as ligands for cobalt(III) in water.	Water	46-51	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	38-41
21056574-0	2011	Atomic-level characterization of the ensemble of the Abeta(1-42) monomer in water using unbiased molecular dynamics simulations and spectral algorithms.	Water	76-81	amyloid beta precursor protein	Homo sapiens	53-58
21056574-2	2011	Recent studies on the structural features of Abeta in water have suggested that the system can be described as an ensemble of distinct conformational species in fast exchange.	Water	54-59	amyloid beta precursor protein	Homo sapiens	45-50
21522869-1	2011	In the title complex, [Co(NCS)(2)(C(13)H(19)N(3)O)(H(2)O)], the Co(II) ion is six-coordinated by the N,N",N""-tridentate Schiff base, the N atoms of two thio-cyanate ligands and one water mol-ecule in a distorted octa-hedral geometry.	Water	182-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
24900309-2	2011	Molecular dynamics simulation in the isopropanol/water cosolvent environment and in water was employed to investigate Bcl-xL protein, which has a highly flexible, large, and primarily hydrophobic binding site.	Water	49-54	BCL2 like 1	Homo sapiens	118-124
21241150-5	2011	By applying this method to SAXS data for the open and closed forms of transferrin at 1 M ion concentration, the correct form could be identified by simply using short MD simulations of the protein in pure water for 0.2 ns.	Water	205-210	transferrin	Homo sapiens	70-81
24900309-2	2011	Molecular dynamics simulation in the isopropanol/water cosolvent environment and in water was employed to investigate Bcl-xL protein, which has a highly flexible, large, and primarily hydrophobic binding site.	Water	84-89	BCL2 like 1	Homo sapiens	118-124
24900309-3	2011	Simulations of either the apo- or holocrystal structures of the Bcl-xL in pure water fail to generate conformations found in the cocrystal structures of Bcl-xL in complex with its binding partners due to hydrophobic collapse.	Water	79-84	BCL2 like 1	Homo sapiens	64-70
21598425-2	2011	We demonstrated that the water extract of O. japonicus led to growth inhibition of LX2 cells by inducing apoptosis through the caspase activation, related to the MAPK pathway.	Water	25-30	mitogen-activated protein kinase 1	Homo sapiens	162-166
21166396-2	2011	This macroinitiator, with a degree of substitution of 0.15, was used in the SET-LRP of methyl acrylate, catalyzed by Cu(0)/Me(6)-TREN in DMSO, DMF, or DMSO/H(2)O in various concentrations.	Water	156-161	LDL receptor related protein 1	Homo sapiens	80-83
21051542-0	2011	Sodium overload and water influx activate the NALP3 inflammasome.	Water	20-25	NLR family pyrin domain containing 3	Homo sapiens	46-51
21522824-1	2011	In the title coordination polymer, [Co(C(14)H(16)O(6))(H(2)O)(2)](n), the Co(II) ion, situated on a twofold rotation axis, is coordinated by four O atoms from two 4,4"-[1,4-phenyl-enebis(-oxy)]dibutano-ate (L) ligands and two water mol-ecules in a highly distorted octa-hedral geometry.	Water	226-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
22040878-4	2011	For this purpose, mice were irradiated with UVB to cause skin injury, followed by individually taken a bath in ERW (ERW-bathing) and tap water (TW-bathing) for 21 d. We examined cytokines profile in acute period, and histological and ultrastructural observation of skin in chronic period.	Water	137-142	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	133-136
22083989-9	2011	Therefore, treatment with water extracted Lycium barbarum and Rehmannia glutinosa (0.05% and 0.15% for each) for eight weeks protects against necrotic damage, indicated by decreases in plasma ALT and AST activities, and suppresses liver fibrosis by down-regulation of liver inflammation in rats with CCl(4)-induced liver injury.	Water	26-31	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	200-203
21127281-5	2011	METHODS: A test rig through which water circulated at different constant rates with ports to insert catheters into a flow chamber was assembled.	Water	34-39	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	16-19
20937248-6	2011	SP is mostly unstructured in water, but appears as extended 3(10) helical or turn III in isotropic bicelles, more pronounced in the presence of GM1.	Water	29-34	tachykinin precursor 1	Homo sapiens	0-2
22040890-1	2011	Catalase protects cells from reactive oxygen species-induced damage by catalyzing the breakdown of hydrogen peroxide to oxygen and water.	Water	131-136	catalase	Homo sapiens	0-8
22102777-8	2011	Docking of TDTBPP with Hnps PLA(2) structure showed coordination with calcium ion directly as well as through the catalytically important water molecule (HOH1260) located at the binding site.	Water	138-143	phospholipase A2 group IB	Homo sapiens	28-34
21691091-1	2011	Aquaporin-2 (AQP2) increases the water permeability of renal collecting ducts in response to vasopressin.	Water	33-38	arginine vasopressin	Homo sapiens	93-104
21280976-10	2011	CONCLUSION: These findings suggest that the reduction of spinal cord oedema in response to SFN administration could be due, in part, to water clearance by AQP4 from the injured spinal cord segments.	Water	136-141	RNA exonuclease 2	Mus musculus	91-94
21165598-5	2011	The limits of detection for the pesticides in water and sediment were below 0.003 mg L-1 and 0.02 mg kg-1, respectively.	Water	46-51	immunoglobulin kappa variable 1-16	Homo sapiens	85-94
21691092-1	2011	BACKGROUND/AIMS: Although aquaglyceroporins have been generally believed to operate in a channel mode, which is of nonsaturable nature, for glycerol as well as for water, we recently found that human aquaporin 9 (hAQP9) operates in a carrier-mediated mode, which is of saturable nature, for glycerol.	Water	164-169	aquaporin 9	Homo sapiens	200-211
21691093-5	2011	As a result, water deprivation was followed by significant upregulation of clathrin (light polypeptide Lcb), serum/glucocorticoid-regulated kinase (SGK) 1, and protein kinase A (PRKA) anchor protein 8-like.	Water	13-18	Protein kinase, cAMP-dependent, catalytic subunit 1	Drosophila melanogaster	160-176
21865736-1	2011	In normal airway epithelium, the cystic fibrosis transmembrane conductance regulator (CFTR) transports Cl(-) ions to the apical surface of the epithelium paralleled by the flow of water through transcellular and paracellular pathways.	Water	180-185	CF transmembrane conductance regulator	Homo sapiens	33-84
21865736-1	2011	In normal airway epithelium, the cystic fibrosis transmembrane conductance regulator (CFTR) transports Cl(-) ions to the apical surface of the epithelium paralleled by the flow of water through transcellular and paracellular pathways.	Water	180-185	CF transmembrane conductance regulator	Homo sapiens	86-90
21691093-5	2011	As a result, water deprivation was followed by significant upregulation of clathrin (light polypeptide Lcb), serum/glucocorticoid-regulated kinase (SGK) 1, and protein kinase A (PRKA) anchor protein 8-like.	Water	13-18	Protein kinase, cAMP-dependent, catalytic subunit 1	Drosophila melanogaster	178-182
20876670-1	2011	BACKGROUND AND OBJECTIVES: In animal models of polycystic kidney disease, the ingestion of large amounts of water promotes diuresis by suppressing plasma levels of arginine vasopressin (AVP) and renal levels of cAMP, slowing cyst progression.	Water	108-113	arginine vasopressin	Homo sapiens	173-184
22178941-7	2011	Sulphurous mineral water and NaHS treatment may have improved the level of testicular GSH by blocking the overexpression of some apoptosis-related regulatory proteins such as Bax/Bcl-2, cytochrome c, caspase-9 and -3, and p53.	Water	19-24	BCL2, apoptosis regulator	Rattus norvegicus	179-184
22178941-7	2011	Sulphurous mineral water and NaHS treatment may have improved the level of testicular GSH by blocking the overexpression of some apoptosis-related regulatory proteins such as Bax/Bcl-2, cytochrome c, caspase-9 and -3, and p53.	Water	19-24	caspase 9	Rattus norvegicus	200-216
20932962-4	2011	In contrast, chloro- and bromohydrins as well as dihalogenides are formed by the addition of HOCl or HOBr to the olefinic groups of the fatty acyl residues of lipids or under the influence of the enzyme myeloperoxidase (MPO) from Cl(-) and H(2)O(2).	Water	240-245	myeloperoxidase	Homo sapiens	203-218
22054130-0	2011	Water-stable fac-{TcO3}+ complexes - a new field of technetium chemistry.	Water	0-5	FA complementation group C	Homo sapiens	13-16
22054130-7	2011	In analogy to [OsO(4)] and [RuO(4)], complexes containing the fac-{TcO(3)}(+) core undergo with alkenes metal-mediated, vicinal cis-dihydroxylation  reactions (alkene-glycol interconversion) in water via a (3+2)-cycloaddition reaction.	Water	194-199	FA complementation group C	Homo sapiens	62-65
22054130-8	2011	Therefore, water-stable fac-{(99m)TcO(3)}(+) complexes pave the way for a new labeling strategy for radiopharmaceutical applications, based on (3+2)-cycloaddition  reactions.	Water	11-16	FA complementation group C	Homo sapiens	24-27
20656072-8	2011	In addition, the number of water molecules in the active site cavity of CYP3A4 anomalously decreases under high pressure due to opening of the active site.	Water	27-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-78
20846002-5	2011	Also, both complexes can cleave pBR-322 DNA in the presence of H(2)O(2), and [Cr(PIP)(2)Cl(2)](+) exhibits more effective activity than [Cr(IP)(2)Cl(2)](+) under the same condition.	Water	63-68	prolactin induced protein	Homo sapiens	81-84
21510837-3	2011	In this review, we summarized the most recent advances that have been made on this area, with particular emphasis on various synthetic approaches, whereby the increase in polarity, water solubility and polar surface area were centralized on, toward potential peripheral-acting CB1 antagonists.	Water	181-186	cannabinoid receptor 1	Homo sapiens	277-280
22272109-9	2011	Taken together, these results suggest that the increase in GSH level by Jeju ground water is, at least in part, due to the effects of vanadyl sulfate via the Nrf2-mediated induction of GCLC.	Water	84-89	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
21528478-1	2011	INTRODUCTION: Angiotensin II (AngII), a peptide that regulates the water-electrolytic balance and blood pressure, is also known to influence cell proliferation.	Water	67-72	angiotensinogen	Homo sapiens	14-28
21528478-1	2011	INTRODUCTION: Angiotensin II (AngII), a peptide that regulates the water-electrolytic balance and blood pressure, is also known to influence cell proliferation.	Water	67-72	angiotensinogen	Homo sapiens	30-35
21290239-4	2011	All the biological and cellular effects of vasopressin are mediated by the interaction of this hormone with three G-protein-coupled receptors - V(1a), V(1b) and V(2).Urological applications are based on the rationale that V(2) receptors mediate water conservation and increase urine osmolality.	Water	245-250	arginine vasopressin	Homo sapiens	43-54
21290239-7	2011	Vasopressin receptor antagonists correct hyponatremia by blocking the activation of the V(2) receptor and induce a free water diuresis without an accompanying natriuresis or kaliuresis; an effect termed "aquaresis".	Water	120-125	arginine vasopressin	Homo sapiens	0-11
22174625-9	2011	Moreover, we found that TaHO1 mRNA could be differentially induced by the well-known nitric oxide (NO) donor sodium nitroprusside (SNP), gibberellin acid (GA), abscisic acid (ABA), hydrogen peroxide (H(2)O(2)) and NaCl treatments.	Water	200-205	heme oxygenase 1, chloroplastic	Triticum aestivum	24-29
21694950-2	2011	Tolvaptan inhibits the binding of arginine vasopressin to the V(2) receptors on the collecting ducts of the kidneys resulting in aquaresis, the electrolytes sparing excretion of water.	Water	178-183	arginine vasopressin	Homo sapiens	43-54
21603106-7	2011	Thus far, clinical trials with vasopressin-receptor antagonists have demonstrated an increase in free-water excretion, improvement in serum sodium, modest improvements in dyspnea but no improvement in mortality.	Water	102-107	arginine vasopressin	Homo sapiens	31-42
21822381-3	2011	As proof of concept, the interaction of paclitaxel with partially unfolded states of human serum albumin was evaluated as a potential method for the preparation of water-soluble complexes of the taxane with albumin.	Water	164-169	albumin	Homo sapiens	97-104
21822379-4	2011	The particle size and entrapment efficiency of recombinant human insulin (rhINS)-loaded sodium glycocholate liposomes can be easily adjusted by tuning the homogenization parameters, phospholipid:sodium glycocholate ratio, insulin:phospholipid ratio, water:ether volume ratio, interior water phase pH, and the hydration buffer pH.	Water	250-255	insulin	Homo sapiens	65-72
21822379-4	2011	The particle size and entrapment efficiency of recombinant human insulin (rhINS)-loaded sodium glycocholate liposomes can be easily adjusted by tuning the homogenization parameters, phospholipid:sodium glycocholate ratio, insulin:phospholipid ratio, water:ether volume ratio, interior water phase pH, and the hydration buffer pH.	Water	285-290	insulin	Homo sapiens	65-72
22114495-4	2011	The SWNT were then conjugated with docetaxel (DTX-SWNT) and linked with NGR (Asn-Gly-Arg) peptide, which targets tumor angiogenesis, to obtain a water-soluble and tumor-targeting SWNT-NGR-DTX drug delivery system.	Water	145-150	reticulon 4 receptor	Mus musculus	72-75
21822381-3	2011	As proof of concept, the interaction of paclitaxel with partially unfolded states of human serum albumin was evaluated as a potential method for the preparation of water-soluble complexes of the taxane with albumin.	Water	164-169	albumin	Homo sapiens	207-214
21184571-8	2011	However, the common approach that uses a bioaccumulation factor (BAF) to predict TR from the exposure-water concentration for organics must be modified slightly for metals because, unlike organics, the BAF for a metal changes as 1) the aqueous exposure concentration changes, and 2) the concentration of other metals changes.	Water	102-107	BAF nuclear assembly factor 1	Homo sapiens	65-68
21822381-4	2011	RESULTS: We found that paclitaxel readily binds to pH-induced partially unfolded albumin, leading to the formation of optically clear water-soluble complexes.	Water	134-139	albumin	Homo sapiens	81-88
21445831-5	2011	RESULTS: In accordance with the leaching-based approaches traditionally used in scaffold manufacturing, the removal of water soluble phases (i.e., PEO and sodium chloride (NaCl) crystals) enables a fully interconnected porous network to be formed, whereas post-extrusion stretching of the melt blend allows a desired elongation of polymer phases to be imparted before the polymer leaching, thus providing a controlled pore alignment.	Water	119-124	twinkle mtDNA helicase	Homo sapiens	147-150
22432323-1	2011	A highly selective ligand exchange type adsorbent was developed for the removal of trace arsenic(V) (As(V)) and phosphate from water.	Water	127-132	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	101-106
21061360-5	2011	The values of water absorption and water diffusion coefficient of PP-g-NIPAAm-i-Col/Chi decreased with increase of the chitosan in the mixture of collagen/chitosan and the value of immobilized collagen/chitosan at the same pH value of buffering water.	Water	14-19	serglycin	Homo sapiens	66-70
21061360-5	2011	The values of water absorption and water diffusion coefficient of PP-g-NIPAAm-i-Col/Chi decreased with increase of the chitosan in the mixture of collagen/chitosan and the value of immobilized collagen/chitosan at the same pH value of buffering water.	Water	35-40	serglycin	Homo sapiens	66-70
21061360-5	2011	The values of water absorption and water diffusion coefficient of PP-g-NIPAAm-i-Col/Chi decreased with increase of the chitosan in the mixture of collagen/chitosan and the value of immobilized collagen/chitosan at the same pH value of buffering water.	Water	35-40	serglycin	Homo sapiens	66-70
21061360-6	2011	The PP-g-NIPAAm-i-Col/Chi have excellent water absorption, water permeability, and antibacterial properties and would be suitable for the healing of wounded skin area.	Water	41-46	serglycin	Homo sapiens	4-8
21061360-6	2011	The PP-g-NIPAAm-i-Col/Chi have excellent water absorption, water permeability, and antibacterial properties and would be suitable for the healing of wounded skin area.	Water	59-64	serglycin	Homo sapiens	4-8
20962025-6	2011	Under these conditions, ERalpha activation selectively prevented increased hydrogen peroxide (H(2)O(2)) and total intracellular reactive oxygen species (ROS) production, caused up-regulation of manganese superoxide dismutase protein and activity, and inhibited prolonged ERK phosphorylation.	Water	94-99	estrogen receptor 1	Homo sapiens	24-31
21175815-5	2011	Then, we observed mitochondrial permeability transition (MPT) and depolarization using confocal microscopy to make clear the mechanism that epimorphin inhibited cell injuries after exposure to H(2)O(2).	Water	193-198	syntaxin 2	Mus musculus	140-150
22432323-10	2011	Therefore, the Zr(IV)-loaded monophosphonic acid resin is an effective ligand exchange adsorbent for removing trace concentrations of As(V) and phosphate from water.	Water	159-164	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	134-139
21691126-7	2011	These data allude to the possibility that interventions directed at lowering vasopressin activity, for example by the administration of vasopressin receptor antagonists or by drinking more water, may be beneficial in chronic kidney disease.	Water	189-194	arginine vasopressin	Homo sapiens	77-88
20135634-0	2011	Conserved water mediated recognition and the dynamics of active site Cys 331 and Tyr 411 in hydrated structure of human IMPDH-II.	Water	10-15	inosine monophosphate dehydrogenase 2	Homo sapiens	120-128
20135634-2	2011	Modeling and extensive molecular dynamics simulation (15 ns) studies of IMPDH-II (1B3O PDB structure) have indicated the intricate involvement of four conserved water molecules (W 1, W 2, W 3, and W 4) in the conformational transition or the mobilities of "flap" (residues 400-450) and "loop" (residues 325-342) regions in enzyme.	Water	161-166	inosine monophosphate dehydrogenase 2	Homo sapiens	72-80
20135634-3	2011	The stabilization of active site residues Asn 303, Gly 324, Ser 329, Cys 331, Asp 364, and Tyr 411 through variable H-bonding coordination from the conserved water molecular center seems interesting in the uninhibited hydrated form of human IMPDH-II structures.	Water	158-163	inosine monophosphate dehydrogenase 2	Homo sapiens	241-249
22129735-8	2011	Immunochemical staining revealed that the AhR and CYP1A2 positive signals were enhanced, and the ARNT positive signal was weakened in the uteri of mice drinking water with TCDD (2 ng/l) and the canal water samples.	Water	161-166	aryl-hydrocarbon receptor	Mus musculus	42-45
22129735-9	2011	These results imply that the canal water contains AhR ligands that could induce similar toxic effects as do low levels of TCDD.	Water	35-40	aryl-hydrocarbon receptor	Mus musculus	50-53
22021627-0	2011	The use of the anti-Glycophorin A antibody in the detection of red blood cell residues in human soft tissue lesions decomposed in air and water: a pilot study.	Water	138-143	glycophorin A (MNS blood group)	Homo sapiens	20-33
20887770-4	2011	In a previous study, we described the time-dependent, stimulatory effects of water deprivation on renal STC-1 mRNA levels in both rats and mice.	Water	77-82	stanniocalcin 1	Rattus norvegicus	104-109
21594790-1	2011	Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel localized primarily at the apical surface of epithelial cells lining the airway, gut, exocrine glands, etc., where it is responsible for transepithelial salt and water transport.	Water	243-248	CF transmembrane conductance regulator	Homo sapiens	0-51
21594790-1	2011	Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel localized primarily at the apical surface of epithelial cells lining the airway, gut, exocrine glands, etc., where it is responsible for transepithelial salt and water transport.	Water	243-248	CF transmembrane conductance regulator	Homo sapiens	53-57
20887770-5	2011	In cortical kidney, STC-1 mRNA levels were increased 8-fold by 72h of water deprivation, whereas the gene response in outer and inner medulla was less pronounced (2-4 fold).	Water	70-75	stanniocalcin 1	Rattus norvegicus	20-25
21103512-2	2011	To this end a bladder instillation fluid is prepared in which the water-insoluble hypericin is solubilized by the presence of human serum albumin (HSA) to which the compound binds.	Water	66-71	albumin	Homo sapiens	138-145
22194645-8	2011	Additionally, the water permeability of AQP0 was calculated by expressing AQP0 with or without the filensin peptide on the cell membrane of Xenopus oocytes by injecting cRNAs for AQP0 and filensin.	Water	18-23	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	74-78
22194645-12	2011	Xenopus oocytes expressing AQP0 on the plasma membrane showed increased water permeability, which was lowered when the filensin COOH-terminal peptide cRNA was coinjected with the cRNA for AQP0.	Water	72-77	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	27-31
22194645-12	2011	Xenopus oocytes expressing AQP0 on the plasma membrane showed increased water permeability, which was lowered when the filensin COOH-terminal peptide cRNA was coinjected with the cRNA for AQP0.	Water	72-77	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	188-192
22194645-14	2011	It appears that interactions between AQP0 and filensin helps to regulate the water permeability of AQP0 and to organize the structure of lens fiber cells, and may also help to maintain the transparency of the lens.	Water	77-82	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	37-41
22194645-14	2011	It appears that interactions between AQP0 and filensin helps to regulate the water permeability of AQP0 and to organize the structure of lens fiber cells, and may also help to maintain the transparency of the lens.	Water	77-82	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	99-103
22194645-0	2011	The effect of the interaction between aquaporin 0 (AQP0) and the filensin tail region on AQP0 water permeability.	Water	94-99	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	38-49
22194645-0	2011	The effect of the interaction between aquaporin 0 (AQP0) and the filensin tail region on AQP0 water permeability.	Water	94-99	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	51-55
22194645-0	2011	The effect of the interaction between aquaporin 0 (AQP0) and the filensin tail region on AQP0 water permeability.	Water	94-99	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	89-93
22194645-1	2011	PURPOSE: To study the interaction between the lens-specific water channel protein, aquaporin 0 (AQP0) and the lens-specific intermediate filament protein, filensin, and the effect of this interaction on the water permeability of AQP0.	Water	60-65	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	83-94
22194645-1	2011	PURPOSE: To study the interaction between the lens-specific water channel protein, aquaporin 0 (AQP0) and the lens-specific intermediate filament protein, filensin, and the effect of this interaction on the water permeability of AQP0.	Water	60-65	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	96-100
22194645-8	2011	Additionally, the water permeability of AQP0 was calculated by expressing AQP0 with or without the filensin peptide on the cell membrane of Xenopus oocytes by injecting cRNAs for AQP0 and filensin.	Water	18-23	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	40-44
22194645-8	2011	Additionally, the water permeability of AQP0 was calculated by expressing AQP0 with or without the filensin peptide on the cell membrane of Xenopus oocytes by injecting cRNAs for AQP0 and filensin.	Water	18-23	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	74-78
20493266-2	2011	In agreement with previous works, the results demonstrate that the effect of gadolinium on water proton relaxivity is not constant, rising moderately with increase in the concentration of bovine serum albumin (BSA).	Water	91-96	albumin	Homo sapiens	195-208
21103512-2	2011	To this end a bladder instillation fluid is prepared in which the water-insoluble hypericin is solubilized by the presence of human serum albumin (HSA) to which the compound binds.	Water	66-71	albumin	Homo sapiens	147-150
21075423-6	2011	Octanol-water partition coefficient (K(ow)), DDT levels in water and the lipid contents had the greatest influences on IELs in the organism bodies.	Water	59-64	D-dopachrome tautomerase	Homo sapiens	45-48
21858088-0	2011	Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain.	Water	47-52	arginine vasopressin	Rattus norvegicus	13-24
21858088-0	2011	Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain.	Water	47-52	arginine vasopressin	Rattus norvegicus	104-115
21625555-0	2011	Modeling a new water channel that allows SET9 to dimethylate p53.	Water	15-20	tumor protein p53	Homo sapiens	61-64
21744658-7	2011	Numerical value n(s) /H2O/ confirms important disparity of micells palisad structure, which are created based on oxyethylated triglycerides nTE = 40.	Water	22-25	patatin like phospholipase domain containing 6	Homo sapiens	140-143
21938926-2	2011	Present review considers the basic methodical approaches being utilized to study vasopressin-induced water transport mechanisms in the cell culture conditions--microscopical methods, electrophysiological measurements, various ways of evaluation of water flow across the cell monolayer, transfections of native and mutant proteins, GFP-technology.	Water	101-106	arginine vasopressin	Homo sapiens	81-92
21938926-2	2011	Present review considers the basic methodical approaches being utilized to study vasopressin-induced water transport mechanisms in the cell culture conditions--microscopical methods, electrophysiological measurements, various ways of evaluation of water flow across the cell monolayer, transfections of native and mutant proteins, GFP-technology.	Water	248-253	arginine vasopressin	Homo sapiens	81-92
20937300-8	2011	Food and water intake were increased, while ethanol intake was decreased, in rats infused with NPY.	Water	9-14	neuropeptide Y	Rattus norvegicus	95-98
22164112-5	2011	Total PAH and PCB concentrations in the surface waters ranged from 4 to 600 ng/L and from 2 to 400 ng/L respectively.	Water	48-54	pyruvate carboxylase	Homo sapiens	14-17
21686211-5	2011	Vasopressin rapidly increases water and urea transport in the terminal inner medullary collecting duct (IMCD).	Water	30-35	arginine vasopressin	Homo sapiens	0-11
22049707-0	2011	Research of waste dump water mutagenicity of bacterial detection system SOS chromotest.	Water	23-28	xylosyltransferase 2	Homo sapiens	72-75
22049707-1	2011	The paper deals with a possible use of the bacterial detection system of SOS chromotest to test mutagenicity of waste dump water checking the mutagenicity degree on real samples from Praksice waste dump, which is a controlled waste dump with mixed industrial, municipal and inert wastes.	Water	123-128	xylosyltransferase 2	Homo sapiens	73-76
21532276-10	2011	Cumulative urinary excretion recoveries with tap water, evian( ) and 100% deep ocean water were 0.98+-0.17%, 0.80+-0.18% and 1.01+-0.16% (mean+-S.E., n=4).	Water	49-54	nuclear RNA export factor 1	Rattus norvegicus	45-48
21126032-5	2010	Considerable water binding by PPI, accompanied by partial dehydration of AOT polar heads, was detected by ATR-FTIR and DSC analysis, suggesting that PPI acted as a "water pump".	Water	13-18	ATR serine/threonine kinase	Homo sapiens	106-109
20971851-1	2010	Vasopressin-regulated water reabsorption through the water channel aquaporin-2 (AQP2) in renal collecting ducts maintains body water homeostasis.	Water	22-27	arginine vasopressin	Homo sapiens	0-11
20971851-1	2010	Vasopressin-regulated water reabsorption through the water channel aquaporin-2 (AQP2) in renal collecting ducts maintains body water homeostasis.	Water	53-58	arginine vasopressin	Homo sapiens	0-11
20971851-2	2010	Vasopressin activates PKA, which phosphorylates AQP2, and this phosphorylation event is required to increase the water permeability and water reabsorption of the collecting duct cells.	Water	113-118	arginine vasopressin	Homo sapiens	0-11
20971851-2	2010	Vasopressin activates PKA, which phosphorylates AQP2, and this phosphorylation event is required to increase the water permeability and water reabsorption of the collecting duct cells.	Water	136-141	arginine vasopressin	Homo sapiens	0-11
20732706-2	2011	Risk assessment studies often use DBP data in water distribution systems (WDS).	Water	46-51	D-box binding PAR bZIP transcription factor	Homo sapiens	34-37
21073171-1	2010	A water-soluble amine-reactive PEGylated analogue of near-infrared emitting dye indocyanine green (5) was synthesized and used to label the anti-HER1 antibody panitumumab (Vectibix) at various equivalents.	Water	2-7	epidermal growth factor receptor	Homo sapiens	145-149
20599566-5	2010	Pups postnatally exposed to only water showed later in adult life behavioral responses when exposed to TMT that were statistically different from mice that were exposed as neonates to TMT.	Water	33-38	tryptase gamma 1	Mus musculus	103-106
20727845-3	2010	Kinetic characterization of bee venom phospholipase A(2) activity at bile salt+phospholipid aggregate-water interfaces was performed using the mixed L+D-lipid surface dilution assay, and interface kinetic parameters were obtained.	Water	102-107	phospholipase A2 group IB	Homo sapiens	38-55
21077627-2	2010	The triureas (L(1), L(2)) show stronger binding of sulfate than tetraureas (L(3), L(4)) in DMSO because of their better conformational complementarity with sulfate, while the tetraureas display better "water tolerance" benefiting from the chelate effect and hydrophobic effect.	Water	202-207	L1 cell adhesion molecule	Homo sapiens	14-18
21047091-0	2010	Water in the polar and nonpolar cavities of the protein interleukin-1beta.	Water	0-5	interleukin 1 beta	Homo sapiens	56-73
21047091-2	2010	The nonpolar cavity in the protein interleukin-1beta has been reported to be filled by water on the basis of some experiments and simulations and to be empty on the basis of others.	Water	87-92	interleukin 1 beta	Homo sapiens	35-52
20884002-1	2010	The structure of the octadecyl (C18) chain layer attached to a silica surface in the presence of binary solvents (acetonitrile/water; methanol/water) was investigated by electron paramagnetic resonance (EPR) and reverse-phase high-performance liquid chromatography (RP-HPLC), using 4-hydroxy-2,2,6,6 tetramethylpiperidine-N-oxyl (Tempol) to mimic the behavior of pollutants with medium-low polarity.	Water	127-132	Bardet-Biedl syndrome 9	Homo sapiens	32-35
20884002-1	2010	The structure of the octadecyl (C18) chain layer attached to a silica surface in the presence of binary solvents (acetonitrile/water; methanol/water) was investigated by electron paramagnetic resonance (EPR) and reverse-phase high-performance liquid chromatography (RP-HPLC), using 4-hydroxy-2,2,6,6 tetramethylpiperidine-N-oxyl (Tempol) to mimic the behavior of pollutants with medium-low polarity.	Water	143-148	Bardet-Biedl syndrome 9	Homo sapiens	32-35
20951028-2	2010	Studies on TIM suggest that the most important general effect of loop closure over the substrate phosphodianion, and the associated conformational changes, is to extrude water from the enzyme active site.	Water	170-175	triosephosphate isomerase 1	Homo sapiens	11-14
21171692-2	2010	Using the extended simple point charge (SPC/E) model for water, nanopores with a uniform radius of 6.0 A are found to fill with water at chemical potentials approximately 0.5 kJ/mol higher than the chemical potential of the saturated vapor.	Water	57-62	proline rich protein gene cluster	Homo sapiens	40-43
21171692-2	2010	Using the extended simple point charge (SPC/E) model for water, nanopores with a uniform radius of 6.0 A are found to fill with water at chemical potentials approximately 0.5 kJ/mol higher than the chemical potential of the saturated vapor.	Water	128-133	proline rich protein gene cluster	Homo sapiens	40-43
20890752-4	2010	Substantiation by MS3 experiments showed that this neutral loss is formed after the loss of water from the precursor ion, indicating phosphate migration along the inositol ring to the glycerol backbone.	Water	92-97	MS3	Homo sapiens	18-21
21053344-5	2010	These effects of H(2)O(2) were suppressed by pretreatment of the cells with selenite (0.1-1 microM) for 24 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2 and inhibition of H(2)O(2)-activated ERK signaling by MEK inhibitor PD98059 blocked the effect of H(2)O(2) on osteoblastic differentiation of VSMCs.	Water	17-22	mitogen-activated protein kinase 3	Homo sapiens	165-171
21053344-5	2010	These effects of H(2)O(2) were suppressed by pretreatment of the cells with selenite (0.1-1 microM) for 24 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2 and inhibition of H(2)O(2)-activated ERK signaling by MEK inhibitor PD98059 blocked the effect of H(2)O(2) on osteoblastic differentiation of VSMCs.	Water	17-22	mitogen-activated protein kinase 1	Homo sapiens	165-168
21053344-5	2010	These effects of H(2)O(2) were suppressed by pretreatment of the cells with selenite (0.1-1 microM) for 24 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2 and inhibition of H(2)O(2)-activated ERK signaling by MEK inhibitor PD98059 blocked the effect of H(2)O(2) on osteoblastic differentiation of VSMCs.	Water	17-22	mitogen-activated protein kinase kinase 7	Homo sapiens	226-229
20976340-1	2010	Two new azido-Co(II) complexes with pyrazine carboxylato ligands, [Co(N(3))(L) H(2)O](n) (L = pyrazine-2-carboxylato) (1) and [CoNa(N(3))(2)(L)](n) (2), have been obtained by carefully tuning the Co(II):N(3)(-) ratio.	Water	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
20976340-1	2010	Two new azido-Co(II) complexes with pyrazine carboxylato ligands, [Co(N(3))(L) H(2)O](n) (L = pyrazine-2-carboxylato) (1) and [CoNa(N(3))(2)(L)](n) (2), have been obtained by carefully tuning the Co(II):N(3)(-) ratio.	Water	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
20486869-5	2010	With such combinations, while ARB inhibits the vasoconstricting action and aldosterone-secreting effects of angiotensin II, hydrochlorothiazide affects the renal tubular mechanisms of electrolyte reabsorption and directly increases excretion of sodium and chloride in the distal tubule, and promotes water excretion.	Water	300-305	angiotensinogen	Homo sapiens	108-122
21139258-8	2010	Overall, the present work demonstrates that some water-soluble cellulose derivatives, such as hydroxypropylcellulose (HPC) and hydroxyethylcellulose (HEC), were suggested to have required properties for a dental drug formulation including bFGF.	Water	49-54	fibroblast growth factor 2	Homo sapiens	239-243
21083618-6	2010	LL-37 also suppressed the expression of IL6, IL8, and CXCL10 genes that was induced by P. gingivalis components, including phenol-water extracts, lipid A, and fimbriae, and the induction of phosphorylation of p38 and extracellular signal-regulated kinase (ERK) by P. gingivalis lipopolysaccharide (LPS).	Water	130-135	cathelicidin antimicrobial peptide	Homo sapiens	0-5
20851859-6	2010	Our preliminary AQP1 data suggest that all the NH3 and less than half of the CO2 move along with H2O through the four monomeric aquapores.	Water	97-100	aquaporin 1 (Colton blood group)	Homo sapiens	16-20
21050852-2	2010	To shed light on the unexpected higher water transport efficiency of killifish AQP0 as compared to mammalian orthologues, we performed a comparative analysis of all available AQP0 sequences and built 3D-models for representatives of different vertebrate classes.	Water	39-44	major intrinsic protein of lens fiber	Homo sapiens	79-83
21050852-3	2010	The analysis shows that air-living organisms evolved specific mutations at pore-lining positions to modulate the AQP0 water transport efficiency while maintaining the correct tertiary/quaternary arrangement to allow the formation of "thin junctions" between lens fiber cells.	Water	118-123	major intrinsic protein of lens fiber	Homo sapiens	113-117
21050852-4	2010	We conclude that the low permeability of mammalian AQP0 is required not to promote cell adhesion, but to modulate the water balance in a dry environment.	Water	118-123	major intrinsic protein of lens fiber	Homo sapiens	51-55
20671274-1	2010	PURPOSE: AQP0, formerly known as MIP26, likely has multiple separate functions in the mammalian lens, including water transport, formation of thin junctions, and interactions with other lens components.	Water	112-117	major intrinsic protein of lens fiber	Homo sapiens	9-13
21157000-4	2010	These are, respectively, enhancement of the intracellular water proton intrinsic NMR relaxation rate 1/T(2a) by paramagnetism of  NO subsequently bonded to iron atoms of intracellular deoxyhemoglobin, and suppression of diffusional water permeability P(d) as a consequence of nitrosylation of aquaporin-1 (AQP1) channel Cys189, either by direct reaction with  NO or with one of the  NO oxidation products, such as N2O3.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	293-304
21157000-4	2010	These are, respectively, enhancement of the intracellular water proton intrinsic NMR relaxation rate 1/T(2a) by paramagnetism of  NO subsequently bonded to iron atoms of intracellular deoxyhemoglobin, and suppression of diffusional water permeability P(d) as a consequence of nitrosylation of aquaporin-1 (AQP1) channel Cys189, either by direct reaction with  NO or with one of the  NO oxidation products, such as N2O3.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	306-310
21157000-5	2010	The bound  NO on the Cys189 thiol residue appears to impose a less efficient barrier to water permeation through AQP1 than the larger carboxyphenylmercuryl residue from p-chloromercuribenzoate.	Water	88-93	aquaporin 1 (Colton blood group)	Homo sapiens	113-117
21322254-1	2010	Combined batch sorption and in situ X-ray absorption fine structure (XAFS) provide direct assessment of the mechanisms for Pb(II) sorption at the soil-water interface under different pH conditions.	Water	151-156	submaxillary gland androgen regulated protein 3B	Homo sapiens	123-129
20671274-1	2010	PURPOSE: AQP0, formerly known as MIP26, likely has multiple separate functions in the mammalian lens, including water transport, formation of thin junctions, and interactions with other lens components.	Water	112-117	major intrinsic protein of lens fiber	Homo sapiens	33-38
20694542-2	2010	In the present study, we aimed to investigate the interaction between the generation of NO and vasopressin (AVP) and corticosterone release after 3 days of water deprivation in rats.	Water	156-161	arginine vasopressin	Rattus norvegicus	95-106
20739617-4	2010	Nevertheless, IRBP-specific T cells pre-exposed to PD-L1(hi) RPE cells displayed substantial suppressor activity, which strongly inhibited the activation of fresh IRBP-Teffs in response to subsequent antigenic challenge and when transferred into naive mice, inhibited the induction of EAU by IRBP-Teff transfer.	Water	285-288	CD274 antigen	Mus musculus	51-56
20919747-8	2010	A putative binding model was proposed based on CoMFA and CoMSIA contour maps and docking simulations; formation of pi-stacking, water bridge and specific hydrogen bonding were deemed important interactions between ligands and PDE-5.	Water	128-133	phosphodiesterase 5A	Homo sapiens	226-231
20814991-10	2010	These results are consistent with a role for MAPK pathways in anhydrobiotic adaptation and suggest that non-anhydrobiotes are able to sense and, at least to some extent, respond appropriately to evaporative water loss.	Water	207-212	mitogen-activated protein kinase 1	Homo sapiens	45-49
20694542-2	2010	In the present study, we aimed to investigate the interaction between the generation of NO and vasopressin (AVP) and corticosterone release after 3 days of water deprivation in rats.	Water	156-161	arginine vasopressin	Rattus norvegicus	108-111
20807796-1	2010	INTRODUCTION: Angiotensin II (AngII) regulates blood pressure and water and electrolyte metabolism through the stimulation of NAD(P)H oxidase and production of reactive oxygen species (ROS) such as O2-, which is metabolised by superoxide dismutase, catalase and glutathione peroxidase.	Water	66-71	angiotensinogen	Rattus norvegicus	14-28
20807796-1	2010	INTRODUCTION: Angiotensin II (AngII) regulates blood pressure and water and electrolyte metabolism through the stimulation of NAD(P)H oxidase and production of reactive oxygen species (ROS) such as O2-, which is metabolised by superoxide dismutase, catalase and glutathione peroxidase.	Water	66-71	angiotensinogen	Rattus norvegicus	30-35
20694542-8	2010	Three days of water deprivation increased significantly the corticosterone levels in plasma (p&lt;0.01) and AVP levels in hypothalamus and plasma (p&lt;0.01), but not in pituitary, which showed a significant decrease.	Water	14-19	arginine vasopressin	Rattus norvegicus	108-111
20694542-10	2010	L-NAME injection abolished significantly (p&lt;0.01) the elevation of plasma corticosterone and hypothalamic AVP levels induced by water deprivation.	Water	131-136	arginine vasopressin	Rattus norvegicus	109-112
20694542-11	2010	These findings showed that in water-deprived rats, nitric oxide synthase inhibition by L-NAME inhibits corticosterone and vasopressin release, suggesting a potent stimulatory role of NO.	Water	30-35	arginine vasopressin	Rattus norvegicus	122-133
20882247-1	2010	We report the synthesis of highly luminescent, water soluble quantum clusters (QCs) of gold, which are stabilized by an iron binding transferrin family protein, lactoferrin (Lf).	Water	47-52	transferrin	Homo sapiens	133-144
20570123-9	2010	CONCLUSIONS: The present in vitro investigations suggest a significant anti-inflammatory activity of willow bark water extract STW 33-1 and of its water-soluble fraction by inhibiting pro-inflammatory cytokines (TNFalpha), COX-2 and nuclear translocation of the transcription factor NF-kappaB in pro-inflammatorily activated monocytes.	Water	113-118	tumor necrosis factor	Homo sapiens	212-220
20570123-9	2010	CONCLUSIONS: The present in vitro investigations suggest a significant anti-inflammatory activity of willow bark water extract STW 33-1 and of its water-soluble fraction by inhibiting pro-inflammatory cytokines (TNFalpha), COX-2 and nuclear translocation of the transcription factor NF-kappaB in pro-inflammatorily activated monocytes.	Water	113-118	prostaglandin-endoperoxide synthase 2	Homo sapiens	223-228
20570123-9	2010	CONCLUSIONS: The present in vitro investigations suggest a significant anti-inflammatory activity of willow bark water extract STW 33-1 and of its water-soluble fraction by inhibiting pro-inflammatory cytokines (TNFalpha), COX-2 and nuclear translocation of the transcription factor NF-kappaB in pro-inflammatorily activated monocytes.	Water	113-118	nuclear factor kappa B subunit 1	Homo sapiens	283-292
20570123-9	2010	CONCLUSIONS: The present in vitro investigations suggest a significant anti-inflammatory activity of willow bark water extract STW 33-1 and of its water-soluble fraction by inhibiting pro-inflammatory cytokines (TNFalpha), COX-2 and nuclear translocation of the transcription factor NF-kappaB in pro-inflammatorily activated monocytes.	Water	147-152	tumor necrosis factor	Homo sapiens	212-220
20570123-9	2010	CONCLUSIONS: The present in vitro investigations suggest a significant anti-inflammatory activity of willow bark water extract STW 33-1 and of its water-soluble fraction by inhibiting pro-inflammatory cytokines (TNFalpha), COX-2 and nuclear translocation of the transcription factor NF-kappaB in pro-inflammatorily activated monocytes.	Water	147-152	prostaglandin-endoperoxide synthase 2	Homo sapiens	223-228
20570123-9	2010	CONCLUSIONS: The present in vitro investigations suggest a significant anti-inflammatory activity of willow bark water extract STW 33-1 and of its water-soluble fraction by inhibiting pro-inflammatory cytokines (TNFalpha), COX-2 and nuclear translocation of the transcription factor NF-kappaB in pro-inflammatorily activated monocytes.	Water	147-152	nuclear factor kappa B subunit 1	Homo sapiens	283-292
20797432-2	2010	In this study we assessed the effects and potential mechanisms of the ruthenium-based water-soluble CO-releasing molecule CORM-3 in the modulation of superoxide dismutase (SOD) activity/binding in vascular endothelial cells (HUVECs).	Water	86-91	superoxide dismutase 3	Homo sapiens	172-175
20800353-3	2010	Our sample of GNS(PF6) was developed for the removal of Pb(II) or Cd(II) ions from water, and the determined adsorption capacities are 406.6 mg/g (pH=5.1) for Pb(II) and 73.42 mg/g (pH=6.2) for Cd(II), which is much higher than that by our previous sample of GNS(C8P) and carbon nanotube.	Water	83-88	submaxillary gland androgen regulated protein 3B	Homo sapiens	56-62
20847049-9	2010	Molecular dynamics simulations suggest that (i) solvation of phospho-Ser(215) and phospho-Ser(269) by positive charged residues or solvent water leads to local unfolding, which is accompanied by local destabilization of the N-terminal loop and global destabilization of p53, and (ii) the double alanine 215/269 mutation disrupts hydrogen bonding normally stabilized by both Ser(215) and Ser(269).	Water	139-144	tumor protein p53	Homo sapiens	270-273
21055716-5	2010	Furthermore, we show that the mutation has a dominant-negative effect on KLF1 transcriptional activity and unexpectedly abolishes the expression of the water channel AQP1 and the adhesion molecule CD44.	Water	152-157	aquaporin 1 (Colton blood group)	Homo sapiens	166-170
20856958-8	2010	We also find that one conserved water has a much stronger interaction with the protein in GluA2, GluK1 and GluK2 compared to the GluN2A receptor.	Water	32-37	glutamate ionotropic receptor kainate type subunit 1	Homo sapiens	97-102
20856958-8	2010	We also find that one conserved water has a much stronger interaction with the protein in GluA2, GluK1 and GluK2 compared to the GluN2A receptor.	Water	32-37	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	129-135
20856958-9	2010	The position of this water molecule is such that it can influence the dynamics of the proposed switch in the GluA2 and GluK1/2 receptors.	Water	21-26	glutamate ionotropic receptor kainate type subunit 1	Homo sapiens	119-124
20964281-7	2010	The experimental results and statistic analysis suggest that both SPC loading level and its water content prior to compounding had significant influences on development of the SPC phase structure and were correlated in determining the morphological structures of the resulting blends.	Water	92-97	proline rich protein gene cluster	Homo sapiens	176-179
20923173-8	2010	In the first binding motif, WT1, the Mg2+ ion is coordinated to D352beta, zinc-bound D297beta, two water molecules, and one oxygen atom from the alpha- and beta-phosphates of farnesyl diphosphate (FPP).	Water	99-104	WT1 transcription factor	Homo sapiens	28-31
20942455-1	2010	The influence of the salts KCl, NaCl, and NaI at molar concentrations on the alpha-helical folding kinetics of the alanine-based oligopeptide Ace-AEAAAKEAAAKA-Nme is investigated by means of (explicit-water) molecular dynamics simulations and a diffusional analysis.	Water	201-206	angiotensin I converting enzyme	Homo sapiens	142-145
20526862-12	2010	When fog water was collected by the LFC, it apparently picked up large amounts of dry deposition which accumulated on the nets during fog-free periods.	Water	9-14	zinc finger protein, FOG family member 1	Homo sapiens	5-8
20688491-5	2010	It was verified that approximately 50% of the insulin was released to Milli-Q water in 800 h release experiments.	Water	78-83	insulin	Homo sapiens	46-53
20739394-6	2010	Water intake and urine volume were increased by ANG II infusion; this increase was higher in TNFR1(-/-) vs. WT mice, whereas body weight and food intake were unaffected.	Water	0-5	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	48-54
20739604-3	2010	Under control conditions, mean arterial pressure (MAP) in response to ANG II rose to the same level for all groups, and middle-aged and old rats drank as much or more water in response to ANG II compared with young rats, depending on whether intakes were analyzed using absolute or body weight-adjusted values.	Water	167-172	angiotensinogen	Rattus norvegicus	188-194
20739606-0	2010	Cloning and characterization of a zebrafish homologue of human AQP1: a bifunctional water and gas channel.	Water	84-89	aquaporin 1 (Colton blood group)	Homo sapiens	63-67
20739606-1	2010	The mammalian aquaporins AQP1, AQP4, and AQP5 have been shown to function not only as water channels but also as gas channels.	Water	86-91	aquaporin 1 (Colton blood group)	Homo sapiens	25-29
20610807-3	2010	Bradykinin-induced dilatation was assessed in the presence and/or absence of pharmacological inhibitors to determine the contribution of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF), as well as that of EDHF-mediated pathways such as myoendothelial gap junctions (MEGJs) and products of arachidonic acid, H(2)O(2) and cytochrome P450 2C9 (CYP2C9).	Water	326-331	kininogen 1	Homo sapiens	0-10
20919734-0	2010	Metal impurities dominate the sorption of a commercially available carbon nanotube for Pb(II) from water.	Water	99-104	submaxillary gland androgen regulated protein 3B	Homo sapiens	87-93
20919734-2	2010	This is a first study showing that metal impurities could dominate the sorption of one type of commercially available CNTs (P-CNTs) for Pb(II) from water, which will help to understand and guide environmental applications of CNTs as a sorbent.	Water	148-153	submaxillary gland androgen regulated protein 3B	Homo sapiens	136-142
20526862-12	2010	When fog water was collected by the LFC, it apparently picked up large amounts of dry deposition which accumulated on the nets during fog-free periods.	Water	9-14	zinc finger protein, FOG family member 1	Homo sapiens	134-137
20853510-5	2010	Here we provide evidence through anatomical colocalization studies that OEG express the water channel aquaporin 1 (AQP1), both in vivo and in vitro.	Water	88-93	aquaporin 1 (Colton blood group)	Homo sapiens	102-113
21046526-2	2010	Arginine vasopressin, the native V2 receptor ligand, stimulates water reabsorption via activation of V2 receptors that are expressed in the collecting ducts of the kidney.	Water	64-69	arginine vasopressin	Homo sapiens	9-20
20853510-5	2010	Here we provide evidence through anatomical colocalization studies that OEG express the water channel aquaporin 1 (AQP1), both in vivo and in vitro.	Water	88-93	aquaporin 1 (Colton blood group)	Homo sapiens	115-119
21284318-3	2010	The concentration of NO3- was found to decrease, as the delta15N-NO3- signature increased, as water flowed through the CW, allowing denitrification rates to be estimated on the basis of the degree of fractionation of delta15N-NO3-.	Water	94-99	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
20924919-7	2010	Synthetic drinking water could be treated effectively by the IOCS- and CIM-based filters reducing As to concentrations lower than 10 mu g L-1.	Water	19-24	immunoglobulin kappa variable 1-16	Homo sapiens	138-141
20545884-7	2010	Both OAT and P5CDH were upregulated during low water potential.	Water	47-52	aldehyde dehydrogenase 4 family member A1	Homo sapiens	13-18
20688078-4	2010	Exposure of myocytes to 30 muM H(2)O(2) (5 min) then 10 U/mL catalase (5 min) increased dihydroethidium (DHE) signal by 58.7 +- 12.0% (n=4) compared to myocytes exposed to 0 muM H(2)O(2) for 5 min followed by 10 U/mL catalase (n=9).	Water	31-36	catalase	Homo sapiens	217-225
20688078-4	2010	Exposure of myocytes to 30 muM H(2)O(2) (5 min) then 10 U/mL catalase (5 min) increased dihydroethidium (DHE) signal by 58.7 +- 12.0% (n=4) compared to myocytes exposed to 0 muM H(2)O(2) for 5 min followed by 10 U/mL catalase (n=9).	Water	178-183	catalase	Homo sapiens	61-69
21170870-4	2010	Recent studies have shown that the CaSR is expressed along the nephron and can play an important role in both calcium and salt absorption, and also in the handling of water in the thick ascending limb.	Water	167-172	calcium sensing receptor	Homo sapiens	35-39
20848345-10	2010	The altered centrally applied AngII response in SHR associated with increased hypothalamic JAK-2/SOCS-3 expression may suggest that abnormal regulation of the central angiotensin pathways may contribute to dysfunction of water-electrolyte homeostasis in SHR.	Water	221-226	angiotensinogen	Rattus norvegicus	30-35
21567611-2	2010	After dissolving these borono-decapeptides in deionized (DI) water, well-defined nanofibers were formed in BP1 (B(OH)(2) VEKELVKEKL-OH) and BP3 (B(OH)(2) AELELARARL-OH).	Water	61-66	BP1	Homo sapiens	107-110
21567611-2	2010	After dissolving these borono-decapeptides in deionized (DI) water, well-defined nanofibers were formed in BP1 (B(OH)(2) VEKELVKEKL-OH) and BP3 (B(OH)(2) AELELARARL-OH).	Water	61-66	BP3	Homo sapiens	140-143
20722976-5	2010	In the present study, to link V2R-related molecules and inner ear hydrops, we examined V2R-linked water channel molecule, aquaporin-2 (AQP2) expression and translocation in human endolymphatic sac.	Water	98-103	arginine vasopressin receptor 2	Homo sapiens	87-90
21141391-0	2010	Soybean peroxidase-catalyzed removal of an aromatic thiol, 2-mercaptobenzothiazole, from water.	Water	89-94	peroxidase	Glycine max	8-18
20736986-1	2010	Vasopressin promotes renal water reabsorption decreasing excretion of free water to dilute plasma and lower serum osmolality.	Water	27-32	arginine vasopressin	Homo sapiens	0-11
20736986-1	2010	Vasopressin promotes renal water reabsorption decreasing excretion of free water to dilute plasma and lower serum osmolality.	Water	75-80	arginine vasopressin	Homo sapiens	0-11
20736986-2	2010	We have good understanding of the causes, mechanisms and consequences of this vasopressin-dependent renal water movement.	Water	106-111	arginine vasopressin	Homo sapiens	78-89
20736986-4	2010	This is so for investigation and discussions of the renal actions of vasopressin are framed primarily around water metabolism rather than any direct effect on salt handling.	Water	109-114	arginine vasopressin	Homo sapiens	69-80
20736986-7	2010	Moreover, although vasopressin action on renal sodium excretion via the V2 receptor is critical to water transport, it is masked easily being situational--for instance, dependent on hydration state.	Water	99-104	arginine vasopressin	Homo sapiens	19-30
20736986-8	2010	It is now clear that an increase in sodium reabsorption along the distal nephron (CNT + CD) mediated by activation of the epithelial Na(+) channel (ENaC) by vasopressin makes an important contribution to maintenance of the axial corticomedullary osmotic gradient necessary for maximal water reabsorption.	Water	285-290	arginine vasopressin	Homo sapiens	157-168
20736986-9	2010	Thus, we need to modify slightly our understanding of vasopressin and its renal actions to include the idea that while vasopressin decreases free water excretion to dilute plasma, it does this, in part, by promoting sodium reabsorption and consequently decreasing sodium excretion via ENaC activated along the distal nephron.	Water	146-151	arginine vasopressin	Homo sapiens	119-130
21284207-1	2010	Microbial catalase is an important industrial enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen.	Water	110-115	catalase	Homo sapiens	10-18
20638704-2	2010	In natural water the main forms are arsenite (As(III)) and arsenate (As(V)).	Water	11-16	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	68-74
20974001-1	2010	BACKGROUND: Nitric oxide (NO) synthesis has been described in several circumventricular and hypothalamic structures in the central nervous system that are implicated in mediating central angiotensin-II (ANG-II) actions during water deprivation and hypovolemia.	Water	226-231	angiotensinogen	Rattus norvegicus	187-201
21060857-9	2010	The structure of the lipid droplet close to the HDL-water interface is altered by the presence of apoA-Is, with most prominent changes being observed for cholesterol and polar lipids.	Water	52-57	apolipoprotein A1	Homo sapiens	98-102
20980598-1	2010	Nonfibrillar, water-soluble low-molecular weight assemblies of the amyloid beta-protein (Abeta) are believed to play an important role in Alzheimer"s disease (AD).	Water	14-19	amyloid beta precursor protein	Homo sapiens	89-94
20540985-0	2010	Induction of the renal stanniocalcin-1 gene in rodents by water deprivation.	Water	58-63	stanniocalcin 1	Rattus norvegicus	23-38
20540985-11	2010	Alternatively, STC-1 could have a role in salt and water balance as dehydration necessitates water conservation as well as controlled natriuresis and kaliuresis.	Water	51-56	stanniocalcin 1	Rattus norvegicus	15-20
20974001-3	2010	RESULTS: Injections of L-NAME or ANG-II produced an increase in plasma vasopressin (VP), oxytocin (OT) and atrial natriuretic peptide (ANP) levels, an increase in water and sodium intake, mean arterial blood pressure and sodium excretion, and a reduction of urinary volume.	Water	163-168	angiotensinogen	Rattus norvegicus	33-39
20974001-1	2010	BACKGROUND: Nitric oxide (NO) synthesis has been described in several circumventricular and hypothalamic structures in the central nervous system that are implicated in mediating central angiotensin-II (ANG-II) actions during water deprivation and hypovolemia.	Water	226-231	angiotensinogen	Rattus norvegicus	203-209
20845925-3	2010	Recrystallization from water/acetone leads to single crystals of H(2)tfBDC 2H(2)O (2, P2(1)/c, Z = 2), where an extensive hydrogen bonding network is found.	Water	23-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	86-100
20969805-3	2010	Water channel proteins, known as aquaporins (AQPs), notably AQP-1 and AQP-4, appears to be involved in the pathophysiology of several neurological diseases.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	60-65
20615510-6	2010	Water samples collected from the Pearl River were analyzed with the proposed method, the concentrations of NP and OP were found to be 2.40 +- 0.16 mug L-1 and 0.037 +- 0.001 mug L-1, respectively.	Water	0-5	immunoglobulin kappa variable 1-16	Homo sapiens	178-181
21231046-0	2010	Bright, coherent, ultrafast soft X-ray harmonics spanning the water window from a tabletop light source.	Water	62-67	AT-rich interaction domain 3A	Homo sapiens	0-6
20845933-1	2010	A fluorescence "turn-on" assay for monitoring protease activity is developed on the basis of a water-soluble carboxylated polyfluorene derivative, PFP-CO2Na, and its different fluorescence response toward cytochrome c (cyt c) and its fragments.	Water	95-100	cytochrome c, somatic	Homo sapiens	205-217
20866083-3	2010	It is proposed that benzoic acid and water compete for the available sixth site on the [(TPA)Fe(III)(OOH)] intermediate, which undergoes O-O bond heterolysis to form, respectively, the Fe(V)(O)(O(2)CAr) and Fe(V)(O)(OH) oxidants that determine the product outcome.	Water	37-42	FEV transcription factor, ETS family member	Homo sapiens	185-190
20866083-3	2010	It is proposed that benzoic acid and water compete for the available sixth site on the [(TPA)Fe(III)(OOH)] intermediate, which undergoes O-O bond heterolysis to form, respectively, the Fe(V)(O)(O(2)CAr) and Fe(V)(O)(OH) oxidants that determine the product outcome.	Water	37-42	FEV transcription factor, ETS family member	Homo sapiens	207-212
21588832-1	2010	In the title compound, [Co(C(10)H(12)NO(2))(3)] H(2)O, the Co(III) ion is coordinated by three O atoms and three N atoms from three bidentate 2-eth-oxy-6-(methyl-imino-meth-yl)phenolate ligands in a slightly distorted octa-hedral environment.	Water	48-53	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	59-66
20950040-2	2010	Water is modeled via the flexible SPC/Fw model where the Coulomb interactions are calculated via the Wolf method which enables the long simulation times required.	Water	0-5	proline rich protein gene cluster	Homo sapiens	34-37
20967245-6	2010	Also, in the first instance for a flavoprotein, CPR is shown to deplete peroxide via diffusible radical mediated process, thereby leading to the formation of water (but without significant evolution of oxygen).	Water	158-163	cytochrome p450 oxidoreductase	Homo sapiens	48-51
20657033-6	2010	A single NtPIP2;1 aquaporin in a tetramer was sufficient to significantly increase the water permeability of the respective yeast cells.	Water	87-92	aquaporin PIP2-7-like	Nicotiana tabacum	18-27
20884853-5	2010	On the other hand, we detected liquid hydration water and strong water-AFP III and water-ubiquitin cross peaks in frozen solution using relaxation filtered (2)H and HETCOR spectra with additional (1)H-(1)H mixing.	Water	65-70	alpha fetoprotein	Homo sapiens	71-74
20884853-5	2010	On the other hand, we detected liquid hydration water and strong water-AFP III and water-ubiquitin cross peaks in frozen solution using relaxation filtered (2)H and HETCOR spectra with additional (1)H-(1)H mixing.	Water	65-70	alpha fetoprotein	Homo sapiens	71-74
20884853-7	2010	For AFP III, the water cross peaks indicate that only a portion of its hydration shell (i.e., at the ice-binding surface) is in contact with the ice lattice.	Water	17-22	alpha fetoprotein	Homo sapiens	4-7
20657033-8	2010	The results confirm the model of an aquaporin monomer as a functional unit for water transport and suggest that, for CO(2)-related transport processes, a structure built up by the tetramer is the basis of this function.	Water	79-84	aquaporin PIP2-7-like	Nicotiana tabacum	36-45
20876952-1	2010	We synthesized a water-insoluble phospholipid polymer bearing a phenylboronic acid moiety (PMBV), which induces cell adhesion through a specific interaction with the glycoprotein, fibronectin.	Water	17-22	fibronectin 1	Homo sapiens	180-191
20676413-0	2010	Link between the hydration enthalpy of lysozyme and the density of its hydration water: Electrostriction.	Water	81-86	lysozyme	Homo sapiens	39-47
20676413-4	2010	The mean mass density of the hydration shell of lysozyme derived from the neutron and X-ray scattering is explained as following the compression of water in the fields of the order of 10(9) V m(-1) due to the charged sites at the boundary of the protein.	Water	148-153	lysozyme	Homo sapiens	48-56
20676413-5	2010	The mean enthalpy of mixing DeltaH(mean) of lysozyme in water calculated on the basis of the measured mean mass density falls in the middle of the values of the enthalpy of mixing DeltaH(mix) observed in sorption experiments.	Water	56-61	lysozyme	Homo sapiens	44-52
20923654-0	2010	Coupling of retinal, protein, and water dynamics in squid rhodopsin.	Water	34-39	rhodopsin	Homo sapiens	58-67
20495178-2	2010	We have previously reported that cystatin M/E deficiency in Cst6(-/-) mice causes neonatal lethality because of excessive transepidermal water loss.	Water	137-142	cystatin E/M	Mus musculus	60-64
20621666-2	2010	A water-soluble polysaccharide with a molar weight of 4.3x10(5)Da, termed as HBP was isolated from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.)	Water	2-7	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	Mus musculus	77-80
20688233-8	2010	After 18 h of fermentation, the water extract of bean showed less ACE inhibitory activity than did the respective 80% ethanol extract.	Water	32-37	angiotensin I converting enzyme	Homo sapiens	66-69
20688233-9	2010	While the water extract of viscous material showed a higher ACE inhibitory activity than the respective ethanol extract.	Water	10-15	angiotensin I converting enzyme	Homo sapiens	60-63
20688233-10	2010	With respect to extraction yield, it was found that the ACE inhibitor in the fermented black soybean could be extracted more efficiently with water than 80% ethanol.	Water	142-147	angiotensin I converting enzyme	Homo sapiens	56-59
22312799-4	2010	The river water composition is increasingly dominated by PO4, NO3 Cl at stations 3 &amp; 4 compared to stations 1 &amp; 2.	Water	10-15	NBL1, DAN family BMP antagonist	Homo sapiens	62-65
20848470-3	2010	METHODS: IRAK-M-competent and -incompetent mice were treated with 3% DSS for 5 days followed by 2 days of regular drinking water.	Water	123-128	interleukin-1 receptor-associated kinase 3	Mus musculus	9-15
20607193-6	2010	Our simulations show that the PfAQP, the human aquaporin 1 (hAQP1) and the Escherichia coli glycerol facilitator (GlpF) have nearly identical water permeabilities.	Water	142-147	aquaporin 1 (Colton blood group)	Homo sapiens	47-58
20731774-1	2010	BACKGROUND: Water retention in advanced cirrhosis and ascites may involve disturbances in renal distal tubular function and in the vasopressin system.	Water	12-17	arginine vasopressin	Homo sapiens	131-142
20731774-6	2010	After the water loading, plasma vasopressin (AVP) decreased significantly in both the groups (P&lt;0.05).	Water	10-15	arginine vasopressin	Homo sapiens	32-43
21180368-4	2010	Tolvaptan antagonises receptors for arginine vasopressin, a hormone that regulates blood sodium levels by stimulating renal water resabsorption.	Water	124-129	arginine vasopressin	Homo sapiens	45-56
20631061-3	2010	Here, we analyze the molecular conditions for adduct formation of the strong human contact sensitizer 2,4-dinitrochlorobenzene (DNCB) and its water-soluble form, 2,4-dinitrobenzenesulfonic acid (DNBS), with both an all amino acid-containing model peptide (+- Cys) and the protein human serum albumin (HSA).	Water	142-147	albumin	Homo sapiens	286-299
20525793-4	2010	Multiple explicit water molecular dynamics simulations of the H4 tail peptide into the catalytic cleft of PARP1 indicate that two stable intermolecular salt bridges hold the peptide in an orientation that allows K16 ADP-ribosylation.	Water	18-23	poly(ADP-ribose) polymerase 1	Homo sapiens	106-111
20798981-8	2010	Furthermore, the LPS antibody was purified well using a water solution, salting-out and gel chromatography.	Water	56-61	toll-like receptor 4	Mus musculus	17-20
20492605-2	2010	The latter is only absent in the extremely rare individuals of the Colton "null" phenotype, usually referred to as Co(a-b-), which lack the water channel AQP1 that carries the Colton antigens.	Water	140-145	aquaporin 1 (Colton blood group)	Homo sapiens	154-158
20599910-9	2010	Consistently, DHT also significantly inhibit the expression of caspase-3, caspase-9 and phospho p38 MAPK induced by H(2)O(2).	Water	116-121	caspase 3	Homo sapiens	63-72
20599910-9	2010	Consistently, DHT also significantly inhibit the expression of caspase-3, caspase-9 and phospho p38 MAPK induced by H(2)O(2).	Water	116-121	mitogen-activated protein kinase 14	Homo sapiens	96-99
20607193-6	2010	Our simulations show that the PfAQP, the human aquaporin 1 (hAQP1) and the Escherichia coli glycerol facilitator (GlpF) have nearly identical water permeabilities.	Water	142-147	aquaporin 1 (Colton blood group)	Homo sapiens	60-65
20661501-0	2010	The role of structured water in mediating general anesthetic action on alpha4beta2 nAChR.	Water	23-28	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	83-88
20661501-5	2010	At the majority of binding sites in alpha4beta2 nAChR, halothane replaced the slow-exchanging water molecules and caused a regional water population decrease.	Water	94-99	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	48-53
20661501-5	2010	At the majority of binding sites in alpha4beta2 nAChR, halothane replaced the slow-exchanging water molecules and caused a regional water population decrease.	Water	132-137	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	48-53
21423434-5	2010	Wistar rats were trained to self-administer tap water or ACD by nose-poking in daily 30 min sessions for 15 consecutive days.	Water	48-53	nuclear RNA export factor 1	Rattus norvegicus	44-47
20541006-1	2010	Glutathione (GSH) and ascorbate (ascorbic acid, vitamin C, ASC) are two critical water-soluble antioxidants in aerobic organisms.	Water	81-86	PYD and CARD domain containing	Homo sapiens	59-62
20542375-1	2010	A study of dechlorination of PCB 138, under visible light employing methylene blue (MB) and triethylamine (TEA) in acetonitrile/water has been conducted to investigate the details of the mechanism of dechlorination and to determine the efficiency of the process for this representative congener.	Water	128-133	pyruvate carboxylase	Homo sapiens	29-32
21423434-6	2010	Response on active nose-poke caused delivery of ACD solution or tap water, whereas responses on inactive nose-poke had no consequences.	Water	68-73	nuclear RNA export factor 1	Rattus norvegicus	64-67
20669212-2	2010	The adsorption of cytochrome c at the silica-water interface was also probed using EW-CRDS and found to be in qualitative agreement with previous studies.	Water	45-50	cytochrome c, somatic	Homo sapiens	18-30
20638963-10	2010	The amounts of Cd(II) and Pb(II) desorbed from bentonite were more than from zeolite, indicating that zeolite was a more effective sorbent for water and wastewater treatment.	Water	143-148	submaxillary gland androgen regulated protein 3B	Homo sapiens	15-32
20638968-0	2010	A novel cellulose-manganese oxide hybrid material by in situ soft chemical synthesis and its application for the removal of Pb(II) from water.	Water	136-141	submaxillary gland androgen regulated protein 3B	Homo sapiens	124-130
20635469-4	2010	The proposed optical sensor was applied successfully to the determination of UO2(2+) ion in tap water and Khoshumi mine concentrated solution samples.	Water	96-101	SEC14 like lipid binding 2	Homo sapiens	92-95
20583210-10	2010	Inclusion of N-acetyl-L-cysteine, a known antioxidant and NF-kappaB inhibitor, in the drinking water led to complete abolition of tumorigenesis in DEN-exposed beta-cat KO.	Water	95-100	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	58-67
20576681-6	2010	Time course studies in rat IMCD suspensions showed maximum phosphorylation within 1 min of dDAVP exposure, consistent with the time course of vasopressin-stimulated phosphorylation of the vasopressin-sensitive water channel aquaporin-2 at Ser256.	Water	210-215	arginine vasopressin	Rattus norvegicus	142-153
20576681-6	2010	Time course studies in rat IMCD suspensions showed maximum phosphorylation within 1 min of dDAVP exposure, consistent with the time course of vasopressin-stimulated phosphorylation of the vasopressin-sensitive water channel aquaporin-2 at Ser256.	Water	210-215	arginine vasopressin	Rattus norvegicus	188-199
20599966-3	2010	Lens shifts protein expression from the more efficient AQP1 in the equatorial epithelial cells to the less efficient water channel, AQP0, in the differentiating secondary fiber cells; perhaps, AQP0 performs a distinctive function.	Water	117-122	major intrinsic protein of lens fiber	Mus musculus	132-136
20599966-3	2010	Lens shifts protein expression from the more efficient AQP1 in the equatorial epithelial cells to the less efficient water channel, AQP0, in the differentiating secondary fiber cells; perhaps, AQP0 performs a distinctive function.	Water	117-122	major intrinsic protein of lens fiber	Mus musculus	193-197
20599966-4	2010	If AQP0 has only water permeability function, can the more efficient water channel AQP1 transgenically expressed in the fiber cells compensate and restore lens transparency in the AQP0 knockout (AQP0(-/-)) mouse?	Water	17-22	major intrinsic protein of lens fiber	Mus musculus	3-7
20573990-6	2010	Our results suggest that, after a period of water deprivation, there develops a sensitivity of the collecting duct to VP that is greater in women.	Water	44-49	arginine vasopressin	Homo sapiens	118-120
20576679-2	2010	We investigated in vivo and in vitro whether vasopressin-induced water reabsorption could be attenuated by ANG II AT1 receptor blockade (losartan).	Water	65-70	arginine vasopressin	Rattus norvegicus	45-56
20730695-2	2010	Vasopressin plays an important role in the pathogenesis of this disorder through its action on the vasopressin type 2 receptor (V(2)R), leading to electrolyte-free water reabsorption.	Water	164-169	arginine vasopressin	Homo sapiens	0-11
20730695-2	2010	Vasopressin plays an important role in the pathogenesis of this disorder through its action on the vasopressin type 2 receptor (V(2)R), leading to electrolyte-free water reabsorption.	Water	164-169	arginine vasopressin	Homo sapiens	99-110
20812145-1	2010	Vasopressin (also known as arginine vasopressin [AVP]) is a small cyclic peptide that acts at the V1a, V1b and V2 GPCRs to regulate a wide range of physiological functions, including vasoconstriction, smooth muscle contractility, response to stress, and excretion of water and sodium via the kidney.	Water	267-272	arginine vasopressin	Homo sapiens	0-11
20812145-1	2010	Vasopressin (also known as arginine vasopressin [AVP]) is a small cyclic peptide that acts at the V1a, V1b and V2 GPCRs to regulate a wide range of physiological functions, including vasoconstriction, smooth muscle contractility, response to stress, and excretion of water and sodium via the kidney.	Water	267-272	arginine vasopressin	Homo sapiens	36-47
20616745-6	2010	In particular, many experimental and clinical studies suggest that psyllium does lower serum and liver cholesterol concentrations and may increase HDL-cholesterol levels- Moreover,water soluble fibres, such as psyllium, moderate post prandial glucose and insulin concentrations in non-insulin dependent diabetic patients, if taken with meals and favour the reduction of body weight and hypertension.	Water	180-185	insulin	Homo sapiens	255-262
20357197-9	2010	CONCLUSIONS: AQP9 was the only water channel expressed in the unmyelinated portion of the ONH and in the GCL whose expression was reduced after IOP elevation.	Water	31-36	aquaporin 9	Rattus norvegicus	13-17
20616745-6	2010	In particular, many experimental and clinical studies suggest that psyllium does lower serum and liver cholesterol concentrations and may increase HDL-cholesterol levels- Moreover,water soluble fibres, such as psyllium, moderate post prandial glucose and insulin concentrations in non-insulin dependent diabetic patients, if taken with meals and favour the reduction of body weight and hypertension.	Water	180-185	insulin	Homo sapiens	285-292
20547329-5	2010	Maximum enzyme production of 140U/g dry fermented substrate was obtained from wheat bran moistened with tap water at a ratio of 1:1.5 and supplemented with 1% (w/w) NH(4)NO(3) and 1% (w/w) lactose after 48h incubation at 37 degrees C. Even though the production of alpha-amylase was lower at 40 and 45 degrees C, the viable cell count was higher.	Water	108-113	common wheat expressed sequence tag	Triticum aestivum	104-107
20596761-5	2010	The PCB included an ortho-nitrophenyl group for photo cleavability and a water-soluble glycol spacer arm ending in a biotin group for enhanced membrane interaction.	Water	73-78	pyruvate carboxylase	Homo sapiens	4-7
20695579-1	2010	Single-molecule total internal reflectance fluorescence microscopy was used to observe the dynamic behavior of &gt;4000 bovine serum albumin objects at the silicone oil-water interface.	Water	169-174	albumin	Homo sapiens	127-140
20738873-0	2010	Computational simulation of vasopressin secretion using a rat model of the water and electrolyte homeostasis.	Water	75-80	arginine vasopressin	Rattus norvegicus	28-39
20738873-2	2010	AVP participates to the hydromineral homeostasis (HH) by controlling water excretion at the level of the kidneys.	Water	69-74	arginine vasopressin	Rattus norvegicus	0-3
20701348-2	2010	The results obtained for two water models (SPC/E and TIP5P-E) at 235 K are essentially the same.	Water	29-34	proline rich protein gene cluster	Homo sapiens	43-46
20470838-3	2010	Topically administered anti-tumor necrosis factor (TNF) monoclonal antibodies formulated within a water-in-oil micro-emulsion were found to have similar pharmaceutical activity to control formulations that were administered by injection.	Water	98-103	tumor necrosis factor	Mus musculus	51-54
20682244-0	2010	Tackling force-field bias in protein folding simulations: folding of Villin HP35 and Pin WW domains in explicit water.	Water	112-117	dynein light chain LC8-type 1	Homo sapiens	85-88
20583323-4	2010	The DESI solvent was water/methanol 1:1 (v/v); measurements were carried out both with and without the addition, as an ionizing agent, of ammonium acetate that enhances the signal intensity of the ammonium adduct ions.	Water	21-26	desumoylating isopeptidase 2	Homo sapiens	4-8
20532698-5	2010	Activation of the sympathetic nervous system and the renin-angiotensin system, leading to renal sodium and water retention, links obesity with hypertension.	Water	107-112	renin	Homo sapiens	53-58
20597530-5	2010	Structural stability and adsorption behavior of Abeta monomer on the SAMs originates from competitive interactions between Abeta and SAM and between SAM and interfacial water, which involve the conformation of Abeta, the surface chemistry of SAM, and the structure and dynamics of interfacial waters.	Water	169-174	amyloid beta precursor protein	Homo sapiens	48-53
20834182-3	2010	Tap water was given to the control group.	Water	4-9	nuclear RNA export factor 1	Rattus norvegicus	0-3
20362052-6	2010	Podocytes treated for 20min with H(2)O(2) (10(-4)M), which mimics reactive oxygen species generation by cells challenged by hyperglycemic or enhanced Pgc conditions, significantly increased the levels of active p38 MAPK, AKT, JNK and ERK1/2.	Water	33-38	progastricsin (pepsinogen C)	Mus musculus	150-153
20362052-6	2010	Podocytes treated for 20min with H(2)O(2) (10(-4)M), which mimics reactive oxygen species generation by cells challenged by hyperglycemic or enhanced Pgc conditions, significantly increased the levels of active p38 MAPK, AKT, JNK and ERK1/2.	Water	33-38	mitogen-activated protein kinase 1	Mus musculus	215-219
20362052-6	2010	Podocytes treated for 20min with H(2)O(2) (10(-4)M), which mimics reactive oxygen species generation by cells challenged by hyperglycemic or enhanced Pgc conditions, significantly increased the levels of active p38 MAPK, AKT, JNK and ERK1/2.	Water	33-38	thymoma viral proto-oncogene 1	Mus musculus	221-224
20434317-5	2010	In this study, the adsorption of three proteins, bovine serum albumin (BSA), lysozyme and insulin, to oil/water interfaces is characterized by interfacial shear stress measurements using a sensitive rheometer equipped with a Du Nouy ring geometry.	Water	106-111	insulin	Homo sapiens	90-97
20110398-0	2010	Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a.	Water	26-31	CF transmembrane conductance regulator	Homo sapiens	75-79
20821618-9	2010	For example, the interaction of PFOA with L-FABP is almost identical to that of the acidic ionizing drugs ketolac, ibuprofen, and warfarin that show specificity to protein partitioning with a magnitude that is proportional to the K(OW) (octanol-water partitioning) of the neutral species.	Water	245-250	fatty acid binding protein 1	Rattus norvegicus	42-48
20815772-1	2010	The present study investigated the effects of oxidative stress induced by reactive oxygen species (ROS), such as hydrogen peroxide (H(2)O(2)) and hydroxyl radical (HO(*)), on the expression of both BRAK , which is also known as non-ELR motif angiostatic CXC chemokine ligand 14 (CXCL14), in head and neck squamous cell carcinoma (HNSCC) cells.	Water	132-137	C-X-C motif chemokine ligand 14	Homo sapiens	198-202
19840149-13	2010	In conclusion, AQP7 and AQP8 were identified in human spermatozoa and could play a role in glycerol metabolism and water transport respectively.	Water	115-120	aquaporin 8	Homo sapiens	24-28
20483383-0	2010	Water-soluble polysaccharide obtained from Acorus calamus L. classically activates macrophages and stimulates Th1 response.	Water	0-5	negative elongation factor complex member C/D, Th1l	Mus musculus	110-113
20476796-10	2010	The analysis further revealed other hydrogen bond interactions, across crucial domains in Bax, which are mediated by water molecules across the length of simulation.	Water	117-122	BCL2 associated X, apoptosis regulator	Homo sapiens	90-93
20110398-7	2010	This nontoxic and water-soluble agent represents a good candidate, alone or in combination with a F508del-CFTR corrector, for the development of a CFTR modulator in cystic fibrosis.	Water	18-23	CF transmembrane conductance regulator	Homo sapiens	147-151
20663042-5	2010	KEY FINDINGS: Oral administration of S. tenuifolia water extract to mice significantly reduced LPS-induced serum levels of TNF-alpha, but not IL-6.	Water	51-56	tumor necrosis factor	Mus musculus	123-132
20663042-6	2010	When peritoneal macrophages were treated in vitro with S. tenuifolia water extract, the inhibition of LPS-induced TNF-alpha was more pronounced than that of IL-6 at the level of secreted protein and mRNA.	Water	69-74	tumor necrosis factor	Mus musculus	114-123
20663042-6	2010	When peritoneal macrophages were treated in vitro with S. tenuifolia water extract, the inhibition of LPS-induced TNF-alpha was more pronounced than that of IL-6 at the level of secreted protein and mRNA.	Water	69-74	interleukin 6	Mus musculus	157-161
20663042-9	2010	CONCLUSIONS: These results indicated that the downregulation of TNF-alpha by S. tenuifolia water extract may have involved the inhibition of both IkappaBalpha degradation and activation of c-Jun and ATF-2 involving suppression of JNK/SAPK.	Water	91-96	tumor necrosis factor	Mus musculus	64-73
20551911-7	2010	Mice receiving rAAV1-Abeta-scFv harbored lower levels of insoluble Abeta and hyperphosphorylated tau, and exhibited improved cognitive function as measured by the Morris Water Maze (MWM) spatial memory task.	Water	170-175	immunglobulin heavy chain variable region	Homo sapiens	27-31
20552997-3	2010	As compared to bare magnetite particles, the hybrids show a high binding capacity for As(III) and As(V), whose presence in the drinking water in wide areas of South Asia has been a huge problem.	Water	136-141	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	98-103
20501663-9	2010	We found that sulfite oxidation mediated by EPO/H(2)O(2) induced the formation of radical-derived DMPO spin-trapped human serum albumin and, to a lesser extent, of DMPO-EPO.	Water	48-54	eosinophil peroxidase	Homo sapiens	169-172
20580399-9	2010	The formation of methyl iodide is unlikely in technical systems such as drinking water treatment i.e. for ppt levels of iodide and low contact times with manganese oxides.	Water	81-86	tachykinin precursor 1	Homo sapiens	106-109
20538280-7	2010	The determination results well met the first stage of the Disinfectants/Disinfection By-Products (D/DBP) Rules established by U.S.EPA and Guidelines for Drinking-water Quality of WHO.	Water	162-167	D-box binding PAR bZIP transcription factor	Homo sapiens	100-103
20493882-6	2010	In order to corroborate our hypothesis concerning the role of this water molecule in FAAH"s catalytic mechanism, we determined the structure of FAAH conjugated to a urea-based inhibitor, PF-3845, to a higher resolution (2.4 A) than previously reported.	Water	67-72	fatty acid amide hydrolase	Homo sapiens	85-89
20493882-6	2010	In order to corroborate our hypothesis concerning the role of this water molecule in FAAH"s catalytic mechanism, we determined the structure of FAAH conjugated to a urea-based inhibitor, PF-3845, to a higher resolution (2.4 A) than previously reported.	Water	67-72	fatty acid amide hydrolase	Homo sapiens	144-148
20493882-8	2010	Examination of the structures of serine hydrolases that are non-homologous to FAAH, such as elastase, trypsin, or chymotrypsin, shows a similarly positioned hydrolytic water molecule and suggests a functional convergence between the amidase signature enzymes and serine proteases.	Water	168-173	fatty acid amide hydrolase	Homo sapiens	78-82
21399280-3	2010	Good agreement with experimental hydration free energies is obtained in the TIP4P and SPC/E water models although the solute"s force field appears to affect the enthalpies and entropies obtained.	Water	92-97	proline rich protein gene cluster	Homo sapiens	86-89
20547454-3	2010	In this study, a novel water-soluble organogermanium compound (Ge-Vit) was prepared because organogermanium is a known INF-gamma inducer.	Water	23-28	vitrin	Homo sapiens	66-69
20491464-3	2010	The incorporation of catalase into a DPPG monolayer at the air-water interface was demonstrated with surface pressure and surface potential isotherms, in addition to polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS).	Water	63-68	catalase	Homo sapiens	21-29
19761816-0	2010	Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion.	Water	0-5	proline rich transmembrane protein 2	Homo sapiens	55-71
19761816-5	2010	Using D54MG glioma cells stably transfected with either AQP1 or AQP4, we show that PKC activity regulates water permeability through phosphorylation of AQP4.	Water	106-111	aquaporin 1 (Colton blood group)	Homo sapiens	56-60
19761816-5	2010	Using D54MG glioma cells stably transfected with either AQP1 or AQP4, we show that PKC activity regulates water permeability through phosphorylation of AQP4.	Water	106-111	proline rich transmembrane protein 2	Homo sapiens	83-86
19761816-6	2010	Activation of PKC with either phorbol 12-myristate 13-acetate or thrombin enhanced AQP4 phosphorylation, reduced water permeability and significantly decreased cell invasion.	Water	113-118	proline rich transmembrane protein 2	Homo sapiens	14-17
19761816-6	2010	Activation of PKC with either phorbol 12-myristate 13-acetate or thrombin enhanced AQP4 phosphorylation, reduced water permeability and significantly decreased cell invasion.	Water	113-118	coagulation factor II, thrombin	Homo sapiens	65-73
19761816-7	2010	Conversely, inhibition of PKC activity with chelerythrine reduced AQP4 phosphorylation, enhanced water permeability and significantly enhanced tumor invasion.	Water	97-102	proline rich transmembrane protein 2	Homo sapiens	26-29
20226201-1	2010	A water deprived animal that ingests only water efficiently corrects its intracellular dehydration, but remains hypovolemic, in negative sodium balance, and with high plasma renin activity and angiotensin II.	Water	2-7	angiotensinogen	Rattus norvegicus	193-207
20226201-10	2010	Angiotensin II apparently sensitizes the brain of the water deprived rat to produce an enhanced sodium intake, as that expressed by spontaneously hypertensive and by young normotensive rat.	Water	54-59	angiotensinogen	Rattus norvegicus	0-14
20346964-4	2010	The second set of experiments focused on the role of intracellular signaling pathways in water and saline intakes that are stimulated by angiotensin II (AngII).	Water	89-94	angiotensinogen	Homo sapiens	137-151
20346964-4	2010	The second set of experiments focused on the role of intracellular signaling pathways in water and saline intakes that are stimulated by angiotensin II (AngII).	Water	89-94	angiotensinogen	Homo sapiens	153-158
20527796-2	2010	This CcO mimic not only performs the selective four-electron reduction of oxygen to water but also catalytically reduces oxygen using the biological one-electron reductant, cytochrome c.	Water	84-89	cytochrome c, somatic	Homo sapiens	173-185
20466003-0	2010	Impaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6).	Water	9-14	adenylate cyclase 6	Mus musculus	79-82
20466003-5	2010	Results of a metabolic cage assay and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) showed for the first time that AC6 plays a critical role in regulating water homeostasis.	Water	172-177	adenylate cyclase 6	Mus musculus	132-135
20562895-7	2010	Overall, current findings indicate a major role of AQP8 in water influx and efflux for sperm volume regulation, which is required for natural fertilization.	Water	59-64	aquaporin 8	Homo sapiens	51-55
20489143-7	2010	Increased transepidermal water loss, a parameter representing barrier defect, was remarkably decreased in grafted Abca12(-/-) skin.	Water	25-30	ATP-binding cassette, sub-family A (ABC1), member 12	Mus musculus	114-120
20617557-3	2010	CYP3A activity has been related with the risk for hypertension in pregnancy, a major cause of morbidity and mortality among women, and CYP3A5*3 could reduce the risk for this disease in populations from regions with high sodium and water availability.	Water	232-237	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-5
20617557-3	2010	CYP3A activity has been related with the risk for hypertension in pregnancy, a major cause of morbidity and mortality among women, and CYP3A5*3 could reduce the risk for this disease in populations from regions with high sodium and water availability.	Water	232-237	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	135-141
20562895-9	2010	The association of AQP11 with the residual cytoplasm of elongated spermatids and the distal tail of spermatozoa supports the hypothesis of more than just a role in conferring water permeability and also in the turnover and recycling of surplus cellular components made redundant during spermiogenesis and spermiation.	Water	175-180	aquaporin 11	Homo sapiens	19-24
20527775-1	2010	Ferrate(VI) (Fe(VI)O(4)(-), Fe(VI)) and ferrate(V) (Fe(V)O(4)(3-), Fe(V)) have a high oxidizing power and upon decomposition form a nontoxic byproduct, Fe(III), which makes them environmentally friendly oxidants in water and wastewater treatment.	Water	215-220	FEV transcription factor, ETS family member	Homo sapiens	52-57
20449725-1	2010	This study explored the feasibility of utilizing a novel adsorbent, poly(hydroxyethylmethacrylate)-grafted coconut coir pith with carboxyl functionality (PGCP-COOH) for the removal of cadmium(II) from water and wastewater.	Water	201-206	carboxypeptidase Q	Homo sapiens	154-158
20653716-6	2010	Drugs that antagonize the action of AVP at the vasopressin V(2) receptor, which is primarily responsible for water resorption in the kidney, are now available and have been studied in patients with HF.	Water	109-114	arginine vasopressin	Homo sapiens	36-39
20653716-6	2010	Drugs that antagonize the action of AVP at the vasopressin V(2) receptor, which is primarily responsible for water resorption in the kidney, are now available and have been studied in patients with HF.	Water	109-114	arginine vasopressin receptor 2	Homo sapiens	47-72
19475484-6	2010	Discriminant analysis identified "pH influence" as the most distinguished factor and pH, Fe, and NO3- as the most discriminating variables and could be treated as water quality indicators.	Water	163-168	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
19496011-4	2010	Ninety-seven percent of the water samples showed nitrate (NO3-) concentrations above the human affected value (13 mg l(-1) NO3-), while 15% exceeded the maximum acceptable level (50 mg l(-1) NO3-) according to WHO regulations.	Water	28-33	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
19496011-4	2010	Ninety-seven percent of the water samples showed nitrate (NO3-) concentrations above the human affected value (13 mg l(-1) NO3-), while 15% exceeded the maximum acceptable level (50 mg l(-1) NO3-) according to WHO regulations.	Water	28-33	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
19496011-4	2010	Ninety-seven percent of the water samples showed nitrate (NO3-) concentrations above the human affected value (13 mg l(-1) NO3-), while 15% exceeded the maximum acceptable level (50 mg l(-1) NO3-) according to WHO regulations.	Water	28-33	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
20825018-7	2010	And the contents of inorganic nitrogen in pond water and sediment displayed a following order: NH4+ -N &gt; NO3- -N &gt; NO2- -N. Data analysis indicated that there was a significantly positive correlation between organic matter and total nitrogen and phosphorus in water and sediment.	Water	47-52	NBL1, DAN family BMP antagonist	Homo sapiens	108-111
19827118-7	2010	Besides, immortalized human epidermal keratinocyte (RHEK-1) epithelial cells could be enhanced to proliferate by IL-1alpha and IL-1beta determined by water-soluble tetrazolium salt (WST-1) assay.	Water	150-155	interleukin 1 beta	Homo sapiens	127-135
20578142-11	2010	Additionally, AQP-1 localizes to plasma membrane blebs, where it increases osmotic water permeability and locally facilitates the rapid, trans-membrane flux of water.	Water	83-88	aquaporin 1 (Colton blood group)	Homo sapiens	14-19
20578142-11	2010	Additionally, AQP-1 localizes to plasma membrane blebs, where it increases osmotic water permeability and locally facilitates the rapid, trans-membrane flux of water.	Water	160-165	aquaporin 1 (Colton blood group)	Homo sapiens	14-19
20578142-12	2010	CONCLUSION: AQP-1 enhances osmotic water permeability and FGF-induced dynamic membrane blebbing in LEC and thereby drives invasion and pathological angiogenesis during cirrhosis.	Water	35-40	aquaporin 1 (Colton blood group)	Homo sapiens	12-17
20371268-7	2010	Plasma AVP concentration curve as a function of water deprivation (WD) time showed a marked increase, reaching its maximal levels within half the time of controls and another significant difference after VCT.	Water	48-53	arginine vasopressin	Rattus norvegicus	7-10
20558542-7	2010	Inhibition of c-Src activity and silencing c-Src expression abrogated the light chain-induced MCP-1 response, but had no effect on H(2)O(2), indicating that production of H(2)O(2) is upstream of c-Src in the signaling cascade.	Water	171-176	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-48
20558542-7	2010	Inhibition of c-Src activity and silencing c-Src expression abrogated the light chain-induced MCP-1 response, but had no effect on H(2)O(2), indicating that production of H(2)O(2) is upstream of c-Src in the signaling cascade.	Water	171-176	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-48
20409716-1	2010	Aquaporin 1 (AQP1) is a molecular water channel expressed in many anatomical locations, particularly in epithelial barriers specialized in water transport.	Water	34-39	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
20409716-1	2010	Aquaporin 1 (AQP1) is a molecular water channel expressed in many anatomical locations, particularly in epithelial barriers specialized in water transport.	Water	34-39	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
20409716-1	2010	Aquaporin 1 (AQP1) is a molecular water channel expressed in many anatomical locations, particularly in epithelial barriers specialized in water transport.	Water	139-144	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
20409716-1	2010	Aquaporin 1 (AQP1) is a molecular water channel expressed in many anatomical locations, particularly in epithelial barriers specialized in water transport.	Water	139-144	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
20588286-1	2010	Vasopressin is a modulator of salt and water reabsorption, with known effects in the thick ascending limb and the collecting duct.	Water	39-44	arginine vasopressin	Homo sapiens	0-11
20209491-0	2010	A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species.	Water	2-7	nuclear factor kappa B subunit 1	Homo sapiens	93-101
19886730-6	2010	In Phase I of the risk assessment, the initial predicted environmental concentration (PEC) of atenolol in surface water (500 ng L-1) exceeded the action limit of 10 ng L-1.	Water	114-119	immunoglobulin kappa variable 1-16	Homo sapiens	128-131
20477957-1	2010	AIMS: The alkaliphilic haloarchaeon Natrialba magadii secretes a halolysin-like protease (Nep) that is active and stable in high salt and in organic solvents, which represents a potential resource for biocatalysis in low water activity conditions.	Water	221-226	membrane metalloendopeptidase	Homo sapiens	90-93
20669724-5	2010	The results highlighted a significant reductive microbial activity in seepage water from either denitrification or dissimilatory nitrate reduction to ammonium (DNRA), leading to nitrate (NO3(-)) consumption.	Water	78-83	NBL1, DAN family BMP antagonist	Homo sapiens	187-190
20550916-4	2010	We purified OmcA and characterized its solution structure by small angle x-ray scattering (SAXS), and its interaction at the hematite-water interface by neutron reflectometry.	Water	134-139	OmcA/MtrC family decaheme c-type cytochrome	Shewanella oneidensis MR-1	12-16
20579398-5	2010	The consumption of spring water led to a trend for an increase in parathyroid hormone (PTH) concentrations while the PTH concentrations remained stable with the intake of the supplemented spring water.	Water	26-31	parathyroid hormone	Homo sapiens	66-85
20579398-5	2010	The consumption of spring water led to a trend for an increase in parathyroid hormone (PTH) concentrations while the PTH concentrations remained stable with the intake of the supplemented spring water.	Water	26-31	parathyroid hormone	Homo sapiens	87-90
20395291-2	2010	Molecular dynamics simulations showed that, although the fewer water molecules in rhodopsin were relatively movable, the hydrogen bond network of the beta2-adrenergic receptor was fully loaded with water molecules that were surprisingly immobilized between the two rotamer switches, both apparently being in their closed conformation.	Water	63-68	rhodopsin	Homo sapiens	82-91
20524689-0	2010	Computational study on the interaction of N1 substituted pyrazole derivatives with B-raf kinase: an unusual water wire hydrogen-bond network and novel interactions at the entrance of the active site.	Water	108-113	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	83-88
20524691-10	2010	However, the C-terminal end of dimeric apoA-I(Milano) wraps around the periphery of the particle to shield the fatty acid chains from water rather than folding back onto the "belt" as does apoA-I(WT).	Water	134-139	apolipoprotein A1	Homo sapiens	39-53
20518532-0	2010	Assembling fibrinogen at air/water and solid/liquid interfaces using Langmuir and Langmuir-Blodgett films.	Water	29-34	fibrinogen beta chain	Homo sapiens	11-21
20572735-0	2010	Two-dimensional wetting: the role of atomic steps on the nucleation of thin water films on BaF2(111) at ambient conditions.	Water	76-81	BANF family member 2	Homo sapiens	91-95
20222694-12	2010	The results from this work have reinforced the hypothesis that the interfacial molecular packing of lipids at the oil-water interface influences the adsorption of bile salts, colipase, and lipase, which in turn impacts the rate of lipolysis.	Water	118-123	colipase	Homo sapiens	175-195
20493295-2	2010	The devices resulted effective for the determination of free and labile Pb(II) in water samples by anodic stripping voltammetry (E(dep) = -600 mV) and in particular 2-mercaptobenzimidazole-5-sulfonate (MBIS) offered the best performances with detection limit of 0.4 microg L(-1).	Water	82-87	submaxillary gland androgen regulated protein 3B	Homo sapiens	72-78
20403973-1	2010	Aquaporin-2 (AQP2), located at the luminal side of the collecting duct principal cells, is a water channel responsible for the final concentration of urine.	Water	93-98	aquaporin 2 S homeolog	Xenopus laevis	0-11
20403973-1	2010	Aquaporin-2 (AQP2), located at the luminal side of the collecting duct principal cells, is a water channel responsible for the final concentration of urine.	Water	93-98	aquaporin 2 S homeolog	Xenopus laevis	13-17
20336700-1	2010	Poly(vinyl alcohol)-pyrene-anti-metadherin (PVA-Py-(Anti-MTDH)), a novel antibody based water soluble probe containing both fluorescent and target sites in the structure for in vitro imaging of breast cancer cells is reported here.	Water	88-93	metadherin	Homo sapiens	32-42
20336700-1	2010	Poly(vinyl alcohol)-pyrene-anti-metadherin (PVA-Py-(Anti-MTDH)), a novel antibody based water soluble probe containing both fluorescent and target sites in the structure for in vitro imaging of breast cancer cells is reported here.	Water	88-93	metadherin	Homo sapiens	57-61
20438352-9	2010	Compared with water-treated control mice, the AcpP PPMO-treated mice showed an approximately 80% reduction in the risk of dying by day 30 of the experiment and relatively little pathology.	Water	14-19	acid phosphatase, prostate	Mus musculus	46-50
20541351-3	2010	The asymmetric stretching frequency of C-C-O group of ethanol in water (1,045 cm(-1)) had been used to calculate BAC using Beer"s Law.	Water	65-70	ryanodine receptor 1	Homo sapiens	39-44
20446703-2	2010	Here, we present molecular dynamics studies on factor Xa (fXa) to investigate the effect of water molecules in this serine protease.	Water	92-97	coagulation factor II, thrombin	Homo sapiens	116-131
19948255-6	2010	The findings suggest that water-induced enrichment of hydrophilic hard domains at the surface changes the local surface physical and chemical properties in a way that influences the conformation of fibrinogen, changing the availability of the platelet-binding sites in the protein.	Water	26-31	fibrinogen beta chain	Homo sapiens	198-208
20171110-1	2010	This paper presents three laboratory experiments, which have been carried out using the Molybdenum-99 (Mo(99)) radiotracer to measure the residence time distribution (RTD), the mixing time and the flow rate in a water flow rig.	Water	212-217	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	223-226
19921479-4	2010	In vivo, taurine were administered to male rats by tap water.	Water	55-60	nuclear RNA export factor 1	Rattus norvegicus	51-54
20359545-4	2010	It seems that bioadhesive delivery systems or water-insoluble powders with absorption enhancers are the most promising methods for intranasal delivery of insulin.	Water	46-51	insulin	Homo sapiens	154-161
21119893-5	2010	We found that CHF1/Hey2 suppresses pathways involved in water transport, adenylate cyclase activity, embryonic eye morphogenesis, gut development and fluid transport after serum stimulation.	Water	56-61	hairy/enhancer-of-split related with YRPW motif 2	Mus musculus	14-18
21119893-5	2010	We found that CHF1/Hey2 suppresses pathways involved in water transport, adenylate cyclase activity, embryonic eye morphogenesis, gut development and fluid transport after serum stimulation.	Water	56-61	hairy/enhancer-of-split related with YRPW motif 2	Mus musculus	19-23
20515797-1	2010	The renin-angiotensin-aldosterone system regulates homeostasis of salt and water, vasoconstriction, and remodeling in cardiovascular and renal cells via activation of intracellular signaling pathway.	Water	75-80	renin	Homo sapiens	4-9
20356933-1	2010	BACKGROUND: The GH/insulin-like growth factor 1 axis is physiologically involved in the regulation of electrolytes and water homeostasis by kidneys, and influences glomerular filtration and tubular re-absorption processes.	Water	119-124	insulin like growth factor 1	Homo sapiens	19-47
20228119-1	2010	Angiotensin II (Ang II) acts at central type 1 (AT(1)) receptors to increase intake of water and saline.	Water	87-92	angiotensinogen	Rattus norvegicus	0-14
20228119-1	2010	Angiotensin II (Ang II) acts at central type 1 (AT(1)) receptors to increase intake of water and saline.	Water	87-92	angiotensinogen	Rattus norvegicus	16-22
20228119-5	2010	Rats given a treatment regimen of three injections of Ang II (300 ng, intracerebroventricular), each separated by 20 min, drank less water than control rats after a subsequent test injection of Ang II.	Water	133-138	angiotensinogen	Rattus norvegicus	54-60
20228119-8	2010	These data support previous suggestions that Ang II-induced water and saline intakes are separable.	Water	60-65	angiotensinogen	Rattus norvegicus	45-51
20370564-2	2010	Therefore, the present study was performed so as to decipher the signalling pathways orchestrating the potential cytoprotective role of heme oxygenase 1 (HOX-1) as well as cyclooxygenase 2 (COX-2) in skeletal myoblasts exposed to H(2)O(2).	Water	230-235	prostaglandin-endoperoxide synthase 2	Homo sapiens	172-188
20370564-2	2010	Therefore, the present study was performed so as to decipher the signalling pathways orchestrating the potential cytoprotective role of heme oxygenase 1 (HOX-1) as well as cyclooxygenase 2 (COX-2) in skeletal myoblasts exposed to H(2)O(2).	Water	230-235	prostaglandin-endoperoxide synthase 2	Homo sapiens	190-195
20571167-0	2010	Role of norepinephrine &amp; angiotensin II in the neural control of renal sodium &amp; water handling in spontaneously hypertensive rats.	Water	88-93	angiotensinogen	Rattus norvegicus	29-43
20571167-11	2010	Typical action of Ang II on salt and water excretions necessitates the presence of an intact renal innervation.	Water	37-42	angiotensinogen	Rattus norvegicus	18-24
21468191-1	2010	When the concentration of sodium (Na(+)) in arterial plasma (P(Na)) declines sufficiently to inhibit the release of vasopressin, water will be excreted promptly when the vast majority of aquaporin 2 water channels (AQP2) have been removed from luminal membranes of late distal nephron segments.	Water	129-134	arginine vasopressin	Rattus norvegicus	116-127
21468197-10	2010	Although the traditional view is that diuretic-induced sodium or volume loss results in vasopressin-induced water retention, the following 3 main factors are implicated in TIH: stimulation of vasopressin secretion, reduced free-water clearance, and increased water intake.	Water	108-113	arginine vasopressin	Homo sapiens	88-99
20107166-4	2010	RESULTS: TLR3-deficient and TLR2+4, TLR2+9, and TLR4+9 double-deficient mice were as susceptible to EAU as their control littermates.	Water	100-103	toll-like receptor 4	Mus musculus	48-52
20460438-7	2010	Under all conditions, water flux in claudin-2-transfected cells was elevated compared with vector controls, indicating claudin-2-mediated paracellular water permeability.	Water	22-27	claudin 2	Canis lupus familiaris	36-45
20460438-7	2010	Under all conditions, water flux in claudin-2-transfected cells was elevated compared with vector controls, indicating claudin-2-mediated paracellular water permeability.	Water	22-27	claudin 2	Canis lupus familiaris	119-128
20460438-7	2010	Under all conditions, water flux in claudin-2-transfected cells was elevated compared with vector controls, indicating claudin-2-mediated paracellular water permeability.	Water	151-156	claudin 2	Canis lupus familiaris	36-45
20460438-7	2010	Under all conditions, water flux in claudin-2-transfected cells was elevated compared with vector controls, indicating claudin-2-mediated paracellular water permeability.	Water	151-156	claudin 2	Canis lupus familiaris	119-128
20460438-10	2010	We conclude that claudin-2, but not claudin-10b, forms a paracellular water channel and thus mediates paracellular water transport in leaky epithelia.	Water	70-75	claudin 2	Canis lupus familiaris	17-26
20460438-10	2010	We conclude that claudin-2, but not claudin-10b, forms a paracellular water channel and thus mediates paracellular water transport in leaky epithelia.	Water	115-120	claudin 2	Canis lupus familiaris	17-26
20378487-6	2010	The municipality of residence for cases and controls was assumed to be the source of the subject"s NO3-N and Mg exposure via drinking water.	Water	134-139	NBL1, DAN family BMP antagonist	Homo sapiens	99-102
20378487-8	2010	Furthermore, we observed evidence of an interaction between drinking water NO3-N and Mg intake via drinking water.	Water	69-74	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
20378487-8	2010	Furthermore, we observed evidence of an interaction between drinking water NO3-N and Mg intake via drinking water.	Water	108-113	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
18814036-2	2010	Growth hormone deficiency (GHD) results in salt and water depletion and studies confirm that replacement leads to sodium and vasopressin-mediated water retention in patients with intact posterior pituitary function.	Water	146-151	arginine vasopressin	Homo sapiens	125-136
20397161-1	2010	Model coniferyl alcohol lignin (the so-called dehydrogenative polymerisate, DHP) was produced in water under homogeneous conditions guaranteed by the presence of a micellised cationic surfactant.	Water	97-102	dihydropyrimidinase	Homo sapiens	76-79
20362698-7	2010	Therefore, p38 and JNK may become promising targets to preserve AQP5 expression and prevent MUC5AC over-expression to restore proper H(2)O to mucin ratio of the airway mucus, which may be beneficial to the clinical management of COPD patients.	Water	133-138	mitogen-activated protein kinase 14	Homo sapiens	11-14
20362698-7	2010	Therefore, p38 and JNK may become promising targets to preserve AQP5 expression and prevent MUC5AC over-expression to restore proper H(2)O to mucin ratio of the airway mucus, which may be beneficial to the clinical management of COPD patients.	Water	133-138	mitogen-activated protein kinase 8	Homo sapiens	19-22
20515102-7	2010	Water simulated at 300 K with the revPBE and at 350 K with BLYP-D or BLYP conforms to this expectation, but the results suggest an earlier onset of system size effects in the BLYP 350 K and revPBE 300 K systems than that observed for either BLYP-D 350 K or SPC/E.	Water	0-5	proline rich protein gene cluster	Homo sapiens	257-260
20524712-6	2010	The prevalence of these highly volatile non-osmotic AVP stimuli during strenuous or prolonged physical activity may reflect a teleological mechanism to promote water conservation during exercise.	Water	160-165	arginine vasopressin	Homo sapiens	52-55
20433197-3	2010	As the deposition voltage is increased into the region where water oxidation prevails, the population of Co(IV) rises and the population of Co(II) decreases.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
20457933-7	2010	The Glu thylakoid membranes are able to perform light-dependent reduction of exogenous cytochrome c with water as the electron donor.	Water	105-110	cytochrome c, somatic	Homo sapiens	87-99
20424115-8	2010	Pretreatment of cells with catalase, a scavenger of H(2)O(2), significantly decreased RET/PTC1 rearrangement formation.	Water	52-57	catalase	Homo sapiens	27-35
20396815-3	2010	In the N6 octahedral 4 : 1-type complex [Co(II)(L10)4](ClO4)2 H2O (25) both axially coordinating N1 unidentate and equatorially bound N2,N(pyr) bidentate ligands L10 are observed.	Water	62-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
20401879-6	2010	The SAM of triad 1 (1/ITO; ITO=indium-tin oxide) has been prepared by immersion of an ITO electrode in a CB solution of 1 and diazabicyclo-octane (2:1 equiv), and characterized by UV/Vis absorption spectroscopy, water contact angle, X-ray photoelectron spectroscopy, and cyclic voltammetry.	Water	212-217	ariadne RBR E3 ubiquitin protein ligase 2	Homo sapiens	11-18
20424115-8	2010	Pretreatment of cells with catalase, a scavenger of H(2)O(2), significantly decreased RET/PTC1 rearrangement formation.	Water	52-57	patched 1	Homo sapiens	90-94
20441871-3	2010	The spectral shift obtained using a combination of water-soluble porphyrin (TPPS) and bovine serum albumin (BSA) was the best among the spectral shifts obtained using different combinations of chromogenic reagents and proteins.	Water	51-56	albumin	Homo sapiens	93-112
20397689-0	2010	Water-soluble atmospheric organic matter in fog: exact masses and chemical formula identification by ultrahigh-resolution fourier transform ion cyclotron resonance mass spectrometry.	Water	0-5	zinc finger protein, FOG family member 1	Homo sapiens	44-47
20397689-1	2010	The detailed molecular composition of water-soluble atmospheric organic matter (AOM) contained in fog water was studied by use of electrospray ionization ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry.	Water	38-43	zinc finger protein, FOG family member 1	Homo sapiens	98-101
20397689-1	2010	The detailed molecular composition of water-soluble atmospheric organic matter (AOM) contained in fog water was studied by use of electrospray ionization ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry.	Water	102-107	zinc finger protein, FOG family member 1	Homo sapiens	98-101
20349911-3	2010	In the present investigation, we demonstrated that 12-o-tetradecanoylphobor-13-acetate (TPA) and constitutively activated PKC alpha significantly increased migration and invasion of HepG2 cells, while treatment with water or polyphenol extracts of SN (SNWE or SNPE) attenuated TPA-induced migration and invasion.	Water	216-221	protein kinase C alpha	Homo sapiens	122-131
20405902-7	2010	The least favored structure, G-3, can be eliminated by annealing the matrix to 35 K. Addition of the first water molecule to G-1 takes place at the carboxylic acid group, with simultaneous hydrogen bonding of the water molecule to the carboxylic acid (C=)O and (O-)H. The results are consistent with the predominance of this structure, although there is evidence for a small amount of a hydrated G-2 structure.	Water	107-112	crystallin gamma E, pseudogene	Homo sapiens	396-399
20428540-3	2010	The all atom CHARMM22 force field is used for the SAM chains together with the SPC/E model for water.	Water	95-100	proline rich protein gene cluster	Homo sapiens	79-82
20428565-1	2010	Catalase and methaemoglobin have very similar haem groups, which are both ferric, yet catalase decomposes hydrogen peroxide to water and oxygen very efficiently, while methaemoglobin does not.	Water	127-132	catalase	Homo sapiens	0-8
20428565-1	2010	Catalase and methaemoglobin have very similar haem groups, which are both ferric, yet catalase decomposes hydrogen peroxide to water and oxygen very efficiently, while methaemoglobin does not.	Water	127-132	catalase	Homo sapiens	86-94
20349911-3	2010	In the present investigation, we demonstrated that 12-o-tetradecanoylphobor-13-acetate (TPA) and constitutively activated PKC alpha significantly increased migration and invasion of HepG2 cells, while treatment with water or polyphenol extracts of SN (SNWE or SNPE) attenuated TPA-induced migration and invasion.	Water	216-221	plasminogen activator, tissue type	Homo sapiens	88-91
26615693-3	2010	The repulsion-dispersion water-water interactions are modeled with a three-site, exp-6 model fitted to the experimental liquid water density and oxygen-oxygen radial distribution function at ambient conditions.	Water	25-30	exportin 6	Homo sapiens	81-86
26615693-3	2010	The repulsion-dispersion water-water interactions are modeled with a three-site, exp-6 model fitted to the experimental liquid water density and oxygen-oxygen radial distribution function at ambient conditions.	Water	31-36	exportin 6	Homo sapiens	81-86
26615693-3	2010	The repulsion-dispersion water-water interactions are modeled with a three-site, exp-6 model fitted to the experimental liquid water density and oxygen-oxygen radial distribution function at ambient conditions.	Water	31-36	exportin 6	Homo sapiens	81-86
20387782-0	2010	How does the reductase help to regulate the catalytic cycle of cytochrome P450 3A4 using the conserved water channel?	Water	103-108	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	63-82
20223824-1	2010	The Na-K-2Cl cotransporter (NKCC1) participates in epithelial transport and in cell volume maintenance by mediating the movement of ions and water across plasma membranes.	Water	141-146	Na-K-2Cl cotransporter 1	Xenopus laevis	28-33
20358558-5	2010	The determination of high-resolution QK(L10A) conformational preferences in water at 313 K allowed us to identify, at atomic resolution, one intermediate of the folding-unfolding pathway.	Water	76-81	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	37-41
20401381-1	2010	Five new water-soluble derivatives of Nile Red 1-5 were prepared.	Water	9-14	adenosine deaminase, RNA-specific, B1	Rattus norvegicus	43-48
20387782-2	2010	Here, we locate the preferred water pathways and their gating mechanisms for the human cytochrome P450 3A4 (CYP3A4) and elucidate the role of the cytochrome P450 reductase (CPR) in turning on and activating these water channels.	Water	30-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	87-106
20387782-2	2010	Here, we locate the preferred water pathways and their gating mechanisms for the human cytochrome P450 3A4 (CYP3A4) and elucidate the role of the cytochrome P450 reductase (CPR) in turning on and activating these water channels.	Water	30-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114
20387782-2	2010	Here, we locate the preferred water pathways and their gating mechanisms for the human cytochrome P450 3A4 (CYP3A4) and elucidate the role of the cytochrome P450 reductase (CPR) in turning on and activating these water channels.	Water	30-35	cytochrome p450 oxidoreductase	Homo sapiens	146-171
20387782-2	2010	Here, we locate the preferred water pathways and their gating mechanisms for the human cytochrome P450 3A4 (CYP3A4) and elucidate the role of the cytochrome P450 reductase (CPR) in turning on and activating these water channels.	Water	30-35	cytochrome p450 oxidoreductase	Homo sapiens	173-176
20387782-2	2010	Here, we locate the preferred water pathways and their gating mechanisms for the human cytochrome P450 3A4 (CYP3A4) and elucidate the role of the cytochrome P450 reductase (CPR) in turning on and activating these water channels.	Water	213-218	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	87-106
20387782-2	2010	Here, we locate the preferred water pathways and their gating mechanisms for the human cytochrome P450 3A4 (CYP3A4) and elucidate the role of the cytochrome P450 reductase (CPR) in turning on and activating these water channels.	Water	213-218	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114
20387782-2	2010	Here, we locate the preferred water pathways and their gating mechanisms for the human cytochrome P450 3A4 (CYP3A4) and elucidate the role of the cytochrome P450 reductase (CPR) in turning on and activating these water channels.	Water	213-218	cytochrome p450 oxidoreductase	Homo sapiens	146-171
20387782-2	2010	Here, we locate the preferred water pathways and their gating mechanisms for the human cytochrome P450 3A4 (CYP3A4) and elucidate the role of the cytochrome P450 reductase (CPR) in turning on and activating these water channels.	Water	213-218	cytochrome p450 oxidoreductase	Homo sapiens	173-176
20387782-8	2010	Indeed, we find that when the FMN domain of CPR binds to CYP3A4, the aqueduct fully opens up, thereby allowing a flow of water molecules.	Water	121-126	cytochrome p450 oxidoreductase	Homo sapiens	44-47
20353187-9	2010	A structural water (WAT1), found above the si-face of the flavin ring in all previously determined MSOX structures, is part of an apparent proton relay system that extends from FAD N(5) to bulk solvent.	Water	13-18	MTOR associated protein, LST8 homolog	Homo sapiens	20-24
20387782-8	2010	Indeed, we find that when the FMN domain of CPR binds to CYP3A4, the aqueduct fully opens up, thereby allowing a flow of water molecules.	Water	121-126	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	57-63
20331576-9	2010	RESULTS: The results showed chronic consumption of ethanol versus water to dose-dependently reduce OX mRNA in the PFLH, with a larger effect observed in rats consuming 2.5 g/kg/d (-70%) or 1.0 g/kg/d (-50%) compared to animals consuming 0.75 g/kg/d (-40%).	Water	66-71	hypocretin neuropeptide precursor	Rattus norvegicus	99-101
20331576-10	2010	In contrast to chronic intake, acute oral ethanol compared to water significantly enhanced OX expression in the PFLH, and this effect occurred at the lower (0.75 g/kg) but not higher (2.5 g/kg) dose of ethanol.	Water	62-67	hypocretin neuropeptide precursor	Rattus norvegicus	91-93
20411239-1	2010	In August of 2005 a study was carried out to evaluate contamination of aliphatic hydrocarbons(AHc) in water, suspended particulate matter (SPM) and sediments from Daliao River system composed of the Hun River, Taizi River, and Daliao River in a heavy industrial area of northeast of China.	Water	102-107	nuclear receptor subfamily 0 group B member 1	Homo sapiens	94-97
20225050-4	2010	The most specific separation with Sil-CEA can be emphasized by the high separation factor (e.g., alpha = 1.39 in methanol-water (7:3, v/v) at 35 degrees C) for 17alpha and 17beta-estradiols, one of the most difficult pairs of isomers in chromatographic separation, whereas for two kinds of commercially available polymeric ODS columns as references alpha = 1.01, only, under the same conditions.	Water	122-127	CEA cell adhesion molecule 3	Homo sapiens	38-41
20085749-0	2010	Effect of monolayer lipid charges on the structure and orientation of protein VAMP1 at the air-water interface.	Water	95-100	vesicle associated membrane protein 1	Homo sapiens	78-83
20085749-3	2010	Here, we report the structure and the assembling behavior of one of the SNARE proteins, VAMP1/synaptobrevin1 incorporated in a lipid monolayer at an air-water interface which mimics the membrane environment.	Water	153-158	small NF90 (ILF3) associated RNA E	Homo sapiens	72-77
20085749-3	2010	Here, we report the structure and the assembling behavior of one of the SNARE proteins, VAMP1/synaptobrevin1 incorporated in a lipid monolayer at an air-water interface which mimics the membrane environment.	Water	153-158	vesicle associated membrane protein 1	Homo sapiens	88-93
20586320-7	2010	At this step, the simulated environment of lysozyme was a water box, and the mica wafer was manually modeled according to its crystal structure.	Water	58-63	lysozyme	Homo sapiens	43-51
20632932-0	2010	Synthetic water-soluble phenolic antioxidant regulates l-arginine metabolism in macrophages: a possible role of Nrf2/ARE.	Water	10-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-116
20632932-1	2010	Synthetic water-soluble phenolic antioxidant TS-13 exhibits pronounced anti-inflammatory properties in vivo and induces intracellular signal system Nrf2/ARE.	Water	10-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	148-152
20439575-12	2010	Growth hormone significantly reduced fat mass, increased lean body mass through an increase in extracellular water, and increased body cell mass in men when coadministered with testosterone.	Water	109-114	growth hormone 1	Homo sapiens	0-14
20411239-2	2010	The content of AHc ranged from 13.39 to 283.62 microg L(-1) in surface water, from 22.68 to 5,725.36 microg g(-1) in dry SPM, and from 61.37 to 229.42 microg g(-1) in dry sediments.	Water	71-76	nuclear receptor subfamily 0 group B member 1	Homo sapiens	15-18
20597365-4	2010	These data for the first time show that furosemide not only decreases sodium reabsorption, but also blocks some componentin molecular mechanism of vasopressin-dependent increase of the osmotic permeability of water.	Water	209-214	arginine vasopressin	Rattus norvegicus	147-158
20382090-3	2010	This paper shows that solid-phase extracts of different types of ultrapure water (UPW) purchased or produced in situ for laboratory analysis (mQ-UPW) may contain organic molecules able to antagonize the binding of E(2) to the human estrogen receptor alpha in the yeast estrogen screen (YES) assay.	Water	75-80	estrogen receptor 1	Homo sapiens	232-255
20178064-3	2010	We tested the hypothesis that water immersion augments exercise-induced ANP release and that the change in ANP availability is associated with increased lipid mobilization and lipid oxidation.	Water	30-35	natriuretic peptide A	Homo sapiens	72-75
20178064-13	2010	Water immersion attenuated epinephrine and norepinephrine and augmented ANP release during exercise.	Water	0-5	natriuretic peptide A	Homo sapiens	72-75
20088912-3	2010	Increased vasopressin secretion reduces water loss in the urine by promoting water reabsorption in the collecting ducts of the kidney.	Water	40-45	arginine vasopressin	Homo sapiens	10-21
19423319-9	2010	In addition, water-soluble extracts of Mukitake powder showed an inhibitory effect on inhibitor of kappaB (IkappaB) kinase (IKK) beta, whose activation is required for nuclear factor kappaB (NFkappaB)-mediated inflammatory response.	Water	13-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	168-189
19423319-9	2010	In addition, water-soluble extracts of Mukitake powder showed an inhibitory effect on inhibitor of kappaB (IkappaB) kinase (IKK) beta, whose activation is required for nuclear factor kappaB (NFkappaB)-mediated inflammatory response.	Water	13-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	191-199
20400641-0	2010	Phosphorylation state of the Na+-K+-Cl- cotransporter (NKCC1) in the gills of Atlantic killifish (Fundulus heteroclitus) during acclimation to water of varying salinity.	Water	143-148	solute carrier family 12 member 2	Fundulus heteroclitus	55-60
20400641-4	2010	Using a phospho-specific antibody, we determined the time course of changes in total and phosphorylated NKCC1 protein during acclimation to water of various salinities.	Water	140-145	solute carrier family 12 member 2	Fundulus heteroclitus	104-109
20400641-7	2010	Increases and decreases in the fractional level of NKCC1 phosphorylation were seen within 1 h of transfer of fish to water of higher and lower salinity, respectively, consistent with a regulatory role of phosphorylation prior to an increase in the biosynthesis of NKCC1; large changes in protein expression of NKCC1 were observed over periods of hours to days.	Water	117-122	solute carrier family 12 member 2	Fundulus heteroclitus	51-56
20149461-6	2010	For the polymeric complex [Ag(ace)](n) the water molecule bridges between two crystallographic equivalent Ag1 atoms which are related each other by a twofold symmetry axis.	Water	43-48	thioredoxin domain containing 12	Homo sapiens	106-109
20163517-5	2010	For the three osmoregulatory organs, AQP3 is constitutively located in the basolateral membrane of the tight-junctioned epithelial cells, allowing water transport between the cytoplasm of these cells and the neighbouring tissue fluid at all times.	Water	147-152	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	37-41
20088912-3	2010	Increased vasopressin secretion reduces water loss in the urine by promoting water reabsorption in the collecting ducts of the kidney.	Water	77-82	arginine vasopressin	Homo sapiens	10-21
20163518-10	2010	Co-localisation of (P)RR with vasopressin in the hypothalamus raised the possibility that (P)RR may be related to the central control of water-electrolyte metabolism and blood pressure.	Water	137-142	arginine vasopressin	Homo sapiens	30-41
20669661-6	2010	The changes of AQP5"s distribution can cause accumulation of water in nasal polyps, HIF-1alpha, VEGF can induce new blood vessels and increase vasopermeability in nasal polyps; they have separate regulatory mechanism in edema formation, but might have some relationships in some ways.	Water	61-66	vascular endothelial growth factor A	Homo sapiens	96-100
20358982-1	2010	A fluorescence susceptible water-soluble paclitaxel was synthesized by a condensation reaction between PEGylated paclitaxel (namely, PP7) and 1-pyrene butyric acid (PBA) in order to obtain a better understanding of the mechanism of action of paclitaxel as well as of the environment of the paclitaxel-binding site.	Water	27-32	protein phosphatase with EF-hand domain 1	Homo sapiens	133-136
20211637-5	2010	An increased osmolality draws water from cells into the blood thus dehydrating specific brain osmoreceptors that stimulate drinking and release of anti diuretic hormone (ADH or vasopressin).	Water	30-35	arginine vasopressin	Homo sapiens	177-188
20501405-1	2010	OBJECTIVE: To investigate the effects of sufentanil pretreatment on acute gastric mucosal lesion and its impact on the expression of acid-sensing ion channel 3 (ASIC3) in thoracic dorsal root ganglia (DRG) neurons in rats with water immersion-restraint stress (WIRS).	Water	227-232	acid sensing ion channel subunit 3	Rattus norvegicus	133-159
20501405-1	2010	OBJECTIVE: To investigate the effects of sufentanil pretreatment on acute gastric mucosal lesion and its impact on the expression of acid-sensing ion channel 3 (ASIC3) in thoracic dorsal root ganglia (DRG) neurons in rats with water immersion-restraint stress (WIRS).	Water	227-232	acid sensing ion channel subunit 3	Rattus norvegicus	161-166
20182791-0	2010	Transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) participate in visceral hyperalgesia in chronic water avoidance stress rat model.	Water	119-124	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	64-69
21116426-0	2010	Screening of clinical, food, water and animal isolates of Escherichia coli for the presence of blaCTX-M extended spectrum beta-lactamase (ESBL) antibiotic resistance gene loci.	Water	29-34	EsbL	Escherichia coli	138-142
20409470-0	2010	Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation.	Water	45-50	aquaporin 1 (Colton blood group)	Homo sapiens	70-81
20149606-3	2010	We have recently shown that human chondrocytes and synoviocytes express aquaporin 1 (AQP1) water channels and that AQP1 is upregulated in RA cartilage.	Water	91-96	aquaporin 1 (Colton blood group)	Homo sapiens	72-83
20149606-3	2010	We have recently shown that human chondrocytes and synoviocytes express aquaporin 1 (AQP1) water channels and that AQP1 is upregulated in RA cartilage.	Water	91-96	aquaporin 1 (Colton blood group)	Homo sapiens	85-89
20184892-3	2010	In this study, we used all-atom molecular dynamics simulations of a transmembrane protein complex between rhodopsin and the heterotrimeric transducin (G alpha beta gamma) in an all-atom DOPC (1,2-dioleoylsn-glycero-3-phosphocholine) membrane-water environment.	Water	242-247	rhodopsin	Homo sapiens	106-115
20409470-3	2010	Although site-directed mutagenesis has shown that mercury binds to Cys189 during the inhibition process, it is not fully understood how this inhibits the water permeation through AQP1.	Water	154-159	aquaporin 1 (Colton blood group)	Homo sapiens	179-183
20409470-6	2010	During each last 10 ns, we observed water permeation events occurred 23 times in Free AQP1 and never in Hg-AQP1.	Water	36-41	aquaporin 1 (Colton blood group)	Homo sapiens	86-90
20067283-2	2010	The effect of adding surfactant cetylpyridinium bromide monohydrate (CPBM) on the adsorption isotherm of PSS was investigated at CPBM concentrations of 3.60 x 10(-7), 1.02 x 10(-5), and 1.04 x 10(-4) M. The use of in situ ATR FTIR allowed for the calculation of the concentration of both PSS and CPBM at the TiO(2)/water interface over the entire course of all experiments.	Water	315-320	PSS	Homo sapiens	105-108
20067283-3	2010	It was found that the addition of a small amount of CPBM, 3.60 x 10(-7) M, to PSS solutions resulted in 23 +/- 3% less PSS accumulating at the TiO(2)/water interface compared to isotherm studies with no CPBM present.	Water	150-155	PSS	Homo sapiens	78-81
20409470-8	2010	In Free AQP1, backbone oxygen atoms of Gly190, Cys191, and Gly192 lined, and were oriented to, the surface of the water pore channel.	Water	114-119	aquaporin 1 (Colton blood group)	Homo sapiens	8-12
20067283-6	2010	For these higher concentrations of CPBM, both PSS and CPBM appear to come to the TiO(2) surface as aggregates and the mole ratio of CPBM to PSS at the TiO(2)/water interface decreases as the concentration of PSS is increased.	Water	158-163	PSS	Homo sapiens	140-143
20409470-9	2010	In Hg-AQP1, however, the SHg+ of Cys191-SHg+ was oriented toward the outside of the water pore.	Water	84-89	aquaporin 1 (Colton blood group)	Homo sapiens	6-10
20067283-6	2010	For these higher concentrations of CPBM, both PSS and CPBM appear to come to the TiO(2) surface as aggregates and the mole ratio of CPBM to PSS at the TiO(2)/water interface decreases as the concentration of PSS is increased.	Water	158-163	PSS	Homo sapiens	140-143
20409470-11	2010	We suggest that mercury disrupts the water pore of AQP1 through local conformational changes in the ar/R region.	Water	37-42	aquaporin 1 (Colton blood group)	Homo sapiens	51-55
20409474-1	2010	The hydrophobic surfactant proteins SP-B and SP-C promote rapid adsorption of pulmonary surfactant to an air/water interface.	Water	109-114	surfactant protein C	Homo sapiens	45-49
20041676-6	2010	Further MD runs are carried out in explicit water for the native structure and the most stable adsorption state to assess the local stability of the geometry obtained in implicit solvent, and to calculate the statistical distribution of the water molecules around the whole lysozyme and its backbone.	Water	241-246	lysozyme	Homo sapiens	274-282
20183853-3	2010	Four kinase systems (Src family, Abl/c-Kit, Syk/ZAP-70, and CDK2/4) were investigated, and differences in predicted water molecule locations and energetics were able to explain the experimentally observed binding selectivity profiles.	Water	116-121	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	37-42
20188908-1	2010	A simple solidification of floating drop microextraction procedure for preconcentration and speciation of trace amounts of As(III) and As(V) in water samples has been proposed prior to electrothermal atomic absorption spectrometry (ETAAS).	Water	144-149	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	135-140
20437588-4	2010	RESULTS: Thrombin reduced brain microvascular endothelial cell (BMVEC) and perivascular astrocyte immunoreactivity-indicating either cell injury or death-and functionally disrupted the BBB as measured by increased water content and extravasation of sodium fluorescein and Evans blue dyes 24 hours later.	Water	214-219	coagulation factor II	Rattus norvegicus	9-17
20089674-1	2010	The action of vasopressin in rodent collecting ducts to regulate water permeability depends in part on increases in phosphorylation of the water channel aquaporin-2 (AQP2) at three sites: Ser256, Ser264, and Ser269.	Water	65-70	arginine vasopressin	Rattus norvegicus	14-25
20089674-1	2010	The action of vasopressin in rodent collecting ducts to regulate water permeability depends in part on increases in phosphorylation of the water channel aquaporin-2 (AQP2) at three sites: Ser256, Ser264, and Ser269.	Water	139-144	arginine vasopressin	Rattus norvegicus	14-25
20379888-3	2010	Based on functional data indicating their possible involvement in water holding capacity and their expression in skeletal muscle, we selected five positional candidates (ACO2, ADSL, CBY1, KCNJ4, PLA2AG6) out of 130 predicted genes in the QTL interval for further analysis.	Water	66-71	aconitase 2	Sus scrofa	170-174
20197185-0	2010	Identification of salivary proteins at oil-water interfaces stabilized by lysozyme and beta-lactoglobulin.	Water	43-48	lysozyme	Homo sapiens	74-82
20168076-0	2010	AQP1 is not only a water channel: It contributes to cell migration through Lin7/beta-catenin.	Water	19-24	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
20107868-8	2010	The results are compatible with the view that a low amount of Cd given in tap water brought about significant changes in circadian expression of redox enzyme and clock genes in rat MBH.	Water	78-83	nuclear RNA export factor 1	Rattus norvegicus	74-77
19885922-6	2010	The calculated cis populations of 14.7 and 14.2% and rotational barriers of 19.87 and 20.57 kcal/mol to the cis-to-trans isomerization for pSer-Pro and pThr-Pro peptides in water, respectively, are consistent with the observed values for pSer-Pro and pThr-Pro containing peptides from NMR experiments.	Water	173-178	parathyroid hormone 1 receptor	Homo sapiens	152-156
19885922-6	2010	The calculated cis populations of 14.7 and 14.2% and rotational barriers of 19.87 and 20.57 kcal/mol to the cis-to-trans isomerization for pSer-Pro and pThr-Pro peptides in water, respectively, are consistent with the observed values for pSer-Pro and pThr-Pro containing peptides from NMR experiments.	Water	173-178	parathyroid hormone 1 receptor	Homo sapiens	251-255
20004757-2	2010	The gene mutated in these patients is CFTR, a Cl(-) channel involved in transepithelial salt and water transport and bicarbonate secretion.	Water	97-102	CF transmembrane conductance regulator	Homo sapiens	38-42
20005095-7	2010	The developed procedure was successfully applied for the removal of both As(III) and As(V) from arsenic contaminated drinking water samples.	Water	126-131	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	85-90
20168076-4	2010	Investigating the possible connection between AQP1 and cytoskeleton, our group showed that such a water channel through Lin7/beta-catenin affects the organization of the cytoskeleton and proposed a model.	Water	98-103	aquaporin 1 (Colton blood group)	Homo sapiens	46-50
20150548-3	2010	METHODS: Chronic hypertension was produced by infusion of angiotensin II and an inhibitor of nitric oxide synthase in drinking water in SOD1 transgenic (SOD1Tg) mice, SOD1-deficient (SOD1(-/-)) mice, and their respective wild-type littermates.	Water	127-132	superoxide dismutase 1, soluble	Mus musculus	136-140
20049499-0	2010	Exploration of the mechanism for LPFFD inhibiting the formation of beta-sheet conformation of A beta(1-42) in water.	Water	110-115	amyloid beta precursor protein	Homo sapiens	94-100
20049499-4	2010	Then, MD simulations on LPFFD/A beta(1-42) in water are carried out.	Water	46-51	amyloid beta precursor protein	Homo sapiens	30-36
20109553-5	2010	Beaded filaments were observed when FN was adsorbed to polysulfonate surface in water; higher ionic strength allowed formation of filamentous structures but altered the regularity of the beads.	Water	80-85	fibronectin 1	Homo sapiens	36-38
20049482-0	2010	AQP1 mediates water transport in the carotid body.	Water	14-19	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
20049482-5	2010	We have also shown that inhibition of AQP1 expression clearly reduced type I cell swelling after a hyposmotic shock, demonstrating that AQP1 has a major contribution in transmembrane water movement in these chemoreceptor cells.	Water	183-188	aquaporin 1 (Colton blood group)	Homo sapiens	38-42
20049482-5	2010	We have also shown that inhibition of AQP1 expression clearly reduced type I cell swelling after a hyposmotic shock, demonstrating that AQP1 has a major contribution in transmembrane water movement in these chemoreceptor cells.	Water	183-188	aquaporin 1 (Colton blood group)	Homo sapiens	136-140
20049482-8	2010	We also show that AQP1 mediates water transport across the cell membrane of type I cells, supporting the contribution of this protein to the osmoreception function of the CB.	Water	32-37	aquaporin 1 (Colton blood group)	Homo sapiens	18-22
19853667-0	2010	TNF-alpha inhibitors in asthma and COPD: we must not throw the baby out with the bath water.	Water	86-91	tumor necrosis factor	Homo sapiens	0-9
20701008-8	2010	The maximum methemoglobin level was 60% and the minimum value of nitrate concentration in the water samples was 396 mg NO3-/L.	Water	94-99	NBL1, DAN family BMP antagonist	Homo sapiens	119-122
20372065-6	2010	Significantly, PLD utilizes ethanol preferentially over water in the hydrolysis reaction that ordinarily generates PA.	Water	56-61	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	15-18
20097328-6	2010	The GROMOS96 force field with the SPC/E water potential can predict successfully the dominant skew-boat to chair conformational transition of the IdoA2S monosaccharide in aqueous solution.	Water	40-45	proline rich protein gene cluster	Homo sapiens	34-37
20051229-0	2010	Water deprivation increases angiotensin-converting enzyme but not AT(1) receptor expression in brainstem and paraventricular nucleus of the hypothalamus of the rat.	Water	0-5	angiotensin I converting enzyme	Rattus norvegicus	28-57
20360842-6	2010	Cognitive and behavioral abnormalities were observed only in Mbnl1 deficient mice, which demonstrate behavior consistent with motivational deficits in the Morris water maze, a complex visuo-spatial task and in the sucrose consumption test for anhedonia.	Water	162-167	muscleblind like splicing factor 1	Mus musculus	61-66
20153476-1	2010	A rapid throughput octanol-water lipophilicity measurement based on 96-well shake-flask and LC/UV/APPI/MS is described.	Water	27-32	amyloid beta precursor protein	Homo sapiens	98-102
20132939-1	2010	The addition of the anionic surfactant sodium dodecyl sulphate (SDS) to hydro-organic mixtures of methanol, ethanol, propanol or acetonitrile with water yielded enhanced peak shape (i.e. increased efficiencies and symmetrical peaks) for a group of basic drugs (beta-blockers) chromatographed with a Kromasil C18 column.	Water	147-152	Bardet-Biedl syndrome 9	Homo sapiens	308-311
20051229-8	2010	These findings suggest that increased Ang II production but not increased receptor expression in the PVH and RVLM is the mechanism by which Ang II in the brain helps to sustain systemic blood pressure during periods of water deprivation.	Water	219-224	angiotensinogen	Rattus norvegicus	38-44
20148593-3	2010	In this work, the antibody of P-gp (anti-P-gp) functionalized water-soluble single-walled carbon nanotubes (Ap-SWNTs) loaded with doxorubicin (Dox), Dox/Ap-SWNTs, were synthesized for challenging the MDR of K562 human leukemia cells.	Water	62-67	ATP binding cassette subfamily B member 1	Homo sapiens	30-34
20148593-3	2010	In this work, the antibody of P-gp (anti-P-gp) functionalized water-soluble single-walled carbon nanotubes (Ap-SWNTs) loaded with doxorubicin (Dox), Dox/Ap-SWNTs, were synthesized for challenging the MDR of K562 human leukemia cells.	Water	62-67	ATP binding cassette subfamily B member 1	Homo sapiens	41-45
20155763-3	2010	Gamma radiolysis of water was used to generate HO*/O(2)(*-) free radicals (I = 10 Gy.min(-1), dose = 400 Gy).	Water	20-25	CD59 molecule (CD59 blood group)	Homo sapiens	85-91
20132793-1	2010	Aquaporin-8 (AQP8) is a membrane channel permeable to water and ammonia.	Water	54-59	aquaporin 8	Rattus norvegicus	13-17
20196621-1	2010	The enantioselective formation of chiral crystal of achiral nucleobase cytosine was achieved mediated by the crystal direction selective dehydration of crystal water in the achiral crystal of cytosine monohydrate (P2(1)/c).	Water	160-165	cyclin dependent kinase inhibitor 1A	Homo sapiens	214-219
20132793-8	2010	Comparative studies indicated that the AQP8-mediated mitochondrial movement of formamide was markedly higher than that of water.	Water	122-127	aquaporin 8	Rattus norvegicus	39-43
19686037-0	2010	Water-Soluble alpha,beta-unsaturated aldehydes of cigarette smoke induce carbonylation of human serum albumin.	Water	0-5	albumin	Homo sapiens	96-109
20205486-1	2010	Tolvaptan is an orally administered, nonpeptide, selective arginine vasopressin V(2) receptor antagonist that increases free water clearance, thereby correcting low serum sodium levels.	Water	125-130	arginine vasopressin receptor 2	Homo sapiens	68-93
20210414-1	2010	In this work, the shear viscosity at ambient conditions of several water models (SPC/E, TIP4P, TIP5P, and TIP4P/2005) is evaluated using the Green-Kubo formalism.	Water	67-72	proline rich protein gene cluster	Homo sapiens	81-84
20152263-9	2010	The detection limits of the method ranged from 0.8 to 2.7 microg L(-1) for spiked river water and 1.4 to 3.1 microg L(-1) for spiked tap water.	Water	137-142	SEC14 like lipid binding 2	Homo sapiens	133-136
20160729-5	2010	The proliferation of RCC cells exposed to IFN-alpha was measured by water-soluble tetrazolium salt assay.	Water	68-73	interferon alpha 1	Homo sapiens	42-51
20007345-1	2010	Vasopressin influences salt and water transport in renal epithelia.	Water	32-37	arginine vasopressin	Rattus norvegicus	0-11
19961829-5	2010	Therefore, Tyr23 is a dominate factor leading to the low water permeability in AQP0.	Water	57-62	major intrinsic protein of lens fiber	Homo sapiens	79-83
19889241-5	2010	After the second carbohydrate load, insulin AUC for CC was 49 % and 57 % greater (P &lt; 0.01) than for DC and W, respectively.	Water	111-112	insulin	Homo sapiens	36-43
19961829-1	2010	Despite sharing overall sequence and structural similarities, water channel aquaporin 0 (AQP0) transports water more slowly than other aquaporins.	Water	62-67	major intrinsic protein of lens fiber	Homo sapiens	89-93
19961829-1	2010	Despite sharing overall sequence and structural similarities, water channel aquaporin 0 (AQP0) transports water more slowly than other aquaporins.	Water	106-111	major intrinsic protein of lens fiber	Homo sapiens	89-93
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Water	126-131	major intrinsic protein of lens fiber	Homo sapiens	40-44
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Water	126-131	aquaporin 1 (Colton blood group)	Homo sapiens	49-53
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Water	126-131	major intrinsic protein of lens fiber	Homo sapiens	158-162
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Water	240-245	major intrinsic protein of lens fiber	Homo sapiens	40-44
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Water	240-245	aquaporin 1 (Colton blood group)	Homo sapiens	49-53
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Water	240-245	major intrinsic protein of lens fiber	Homo sapiens	158-162
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Water	240-245	major intrinsic protein of lens fiber	Homo sapiens	40-44
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Water	240-245	aquaporin 1 (Colton blood group)	Homo sapiens	49-53
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Water	240-245	major intrinsic protein of lens fiber	Homo sapiens	158-162
19961829-3	2010	Comparisons of free-energy and interaction-energy profiles for water conduction between AQP0 and AQP1 indicate that this interruption of the water chain causes a huge energy barrier opposing water translocation through AQP0.	Water	63-68	major intrinsic protein of lens fiber	Homo sapiens	88-92
19961829-3	2010	Comparisons of free-energy and interaction-energy profiles for water conduction between AQP0 and AQP1 indicate that this interruption of the water chain causes a huge energy barrier opposing water translocation through AQP0.	Water	63-68	aquaporin 1 (Colton blood group)	Homo sapiens	97-101
19961829-3	2010	Comparisons of free-energy and interaction-energy profiles for water conduction between AQP0 and AQP1 indicate that this interruption of the water chain causes a huge energy barrier opposing water translocation through AQP0.	Water	63-68	major intrinsic protein of lens fiber	Homo sapiens	219-223
19961829-3	2010	Comparisons of free-energy and interaction-energy profiles for water conduction between AQP0 and AQP1 indicate that this interruption of the water chain causes a huge energy barrier opposing water translocation through AQP0.	Water	141-146	major intrinsic protein of lens fiber	Homo sapiens	88-92
19961829-3	2010	Comparisons of free-energy and interaction-energy profiles for water conduction between AQP0 and AQP1 indicate that this interruption of the water chain causes a huge energy barrier opposing water translocation through AQP0.	Water	141-146	aquaporin 1 (Colton blood group)	Homo sapiens	97-101
19961829-3	2010	Comparisons of free-energy and interaction-energy profiles for water conduction between AQP0 and AQP1 indicate that this interruption of the water chain causes a huge energy barrier opposing water translocation through AQP0.	Water	141-146	major intrinsic protein of lens fiber	Homo sapiens	219-223
19961829-3	2010	Comparisons of free-energy and interaction-energy profiles for water conduction between AQP0 and AQP1 indicate that this interruption of the water chain causes a huge energy barrier opposing water translocation through AQP0.	Water	141-146	major intrinsic protein of lens fiber	Homo sapiens	88-92
19961829-3	2010	Comparisons of free-energy and interaction-energy profiles for water conduction between AQP0 and AQP1 indicate that this interruption of the water chain causes a huge energy barrier opposing water translocation through AQP0.	Water	141-146	aquaporin 1 (Colton blood group)	Homo sapiens	97-101
20429274-4	2010	The positions of the absorption and fluorescence maxima and the value of the Stokes shift for the complex of Na-Hy with human serum albumin increases when D20 instead of common water is used as a solvent.	Water	177-182	albumin	Homo sapiens	126-139
20127047-0	2010	The effect of CAG repeat polymorphism in the glucocorticoid receptor on stress responses of mice exposed to water-immersion restraint stress.	Water	108-113	nuclear receptor subfamily 3, group C, member 1	Mus musculus	45-68
19931432-2	2010	The effects of a direct incubation of egg yolk (EY) by phospholipase D (PLD) with respect to EY structure and interface properties of oil-in-water (o/w)-emulsions prepared with this EY were investigated.	Water	141-146	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	72-75
20467590-2	2010	In response to elevated serum osmolality, vasopressin acts on V2 renal receptors increasing water reabsorption and causing serum sodium to decrease.	Water	92-97	arginine vasopressin	Homo sapiens	42-53
19961829-3	2010	Comparisons of free-energy and interaction-energy profiles for water conduction between AQP0 and AQP1 indicate that this interruption of the water chain causes a huge energy barrier opposing water translocation through AQP0.	Water	141-146	major intrinsic protein of lens fiber	Homo sapiens	219-223
19961829-4	2010	We further show that a mutation of Tyr23 to phenylalanine leads to a 2- to 4-fold enhancement in water permeability of AQP0, from (0.5+/-0.2) x 10(-14) cm(3)s(-1) to (1.9+/-0.6) x 10(-14) cm(3)s(-1).	Water	97-102	major intrinsic protein of lens fiber	Homo sapiens	119-123
20009254-0	2010	Simultaneous determination of 42 organic chemicals in bottled water by combining C18 extraction disk with GC-MS and LC/MS/MS technique.	Water	62-67	Bardet-Biedl syndrome 9	Homo sapiens	81-84
20329818-7	2010	The ultrasound speed gap at beta=1 is confirmed by the experimental results, showing that it increases in less cross-linked gel samples which own a higher concentration of bounded water.	Water	180-185	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	28-34
19650071-9	2010	Subsequently, HSMD was applied to mobile loops of the enzymes porcine pancreatic alpha-amylase and acetylcholinesterase in explicit water, where the difference in F between the bound and free states of the loop was calculated.	Water	132-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-119
20009254-2	2010	Hazard compounds in bottled water were extracted with a solid phase extraction step using C18 disks.	Water	28-33	Bardet-Biedl syndrome 9	Homo sapiens	90-93
20034965-4	2010	At variance with the water transport phenotype previously described in AtPIP2;2 knockout mutants, disruption of AtPIP1;2 reduced by 20% to 30% the root hydrostatic hydraulic conductivity but did not modify osmotic root water transport.	Water	21-26	plasma membrane intrinsic protein 1B	Arabidopsis thaliana	112-120
19713953-13	2010	After intervention, water consumption significantly increased in the IG equally among both, non-MIG and MIG, by ~1 glass/day.	Water	20-25	C-X-C motif chemokine ligand 9	Homo sapiens	96-99
19713953-13	2010	After intervention, water consumption significantly increased in the IG equally among both, non-MIG and MIG, by ~1 glass/day.	Water	20-25	C-X-C motif chemokine ligand 9	Homo sapiens	104-107
19713953-14	2010	A simple school-based intervention promoting water consumption prevented overweight in non-MIG children, but failed in MIG children.	Water	45-50	C-X-C motif chemokine ligand 9	Homo sapiens	91-94
20034965-0	2010	A PIP1 aquaporin contributes to hydrostatic pressure-induced water transport in both the root and rosette of Arabidopsis.	Water	61-66	plasma membrane intrinsic protein 1A	Arabidopsis thaliana	2-6
20034965-10	2010	Mutant analysis showed that, under prolonged darkness conditions, AtPIP1;2 can contribute to up to approximately 20% of K(ros) and to the osmotic water permeability of isolated mesophyll protoplasts.	Water	146-151	plasma membrane intrinsic protein 1B	Arabidopsis thaliana	66-74
20104549-4	2010	Surface pressure versus area isotherms indicate that lysozyme is adsorbed by the surfactant-clay L-B film at the air-water interface without phase transition.	Water	117-122	lysozyme	Homo sapiens	53-61
19948840-2	2010	Aquaporin 9 (AQP9), which allows permeation of water and neutral solutes, is abundant throughout the male reproductive tract, where it is expressed at the apical membrane of rat epididymal principal cells as early as at 1 week of age.	Water	47-52	aquaporin 9	Rattus norvegicus	0-11
19948840-2	2010	Aquaporin 9 (AQP9), which allows permeation of water and neutral solutes, is abundant throughout the male reproductive tract, where it is expressed at the apical membrane of rat epididymal principal cells as early as at 1 week of age.	Water	47-52	aquaporin 9	Rattus norvegicus	13-17
20047857-2	2010	In Tris-HCl buffer solution (pH 7.4), water-soluble semiconductor CdSe quantum dots (QDs) reacted with HSA and the products resulted in a great enhancement of the intensity of resonance Rayleigh scattering (RRS) and second-order scattering (SOS).	Water	38-43	albumin	Homo sapiens	103-106
21789879-7	2010	The incidences of adverse reactions (respiratory rate &gt; or =35 breaths/min or oxygen saturation &lt; or =89% for &gt; or =1 min) were relatively high for the 21% O2-0 and 5 cm H2O CPAP groups (20 patients each) and low for the 40% O(2)-5 cmH2O CPAP group (2 patients).	Water	179-182	troponin T2, cardiac type	Homo sapiens	241-245
20054232-0	2010	Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling.	Water	17-22	tumor necrosis factor	Homo sapiens	81-90
20054232-2	2010	In this study, water extract of Grifola frondosa (GFW) was evaluated for its protective effects against colon inflammation through the modulation of TNF-alpha action.	Water	15-20	tumor necrosis factor	Homo sapiens	149-158
20449413-3	2010	AlF(bdc) does not absorb water at ambient temperatures and shows absorption properties similar to VO(bdc).	Water	25-30	general transcription factor IIA subunit 1 like	Homo sapiens	0-3
20149227-9	2010	Contrary to humans and some rodents, intrachromosomal duplicates of zebrafish AQP8 were water and urea permeable, while the genomic duplicate only transported water.	Water	88-93	aquaporin 8a, tandem duplicate 1	Danio rerio	78-82
20095579-10	2010	This allows us to utilize PS2.M for quantitative analysis of aqueous Pb(2+) using the ABTS-H(2)O(2) colorimetric system and luminol-H(2)O(2) CL system.	Water	91-96	taste 2 receptor member 64 pseudogene	Homo sapiens	26-29
19969073-6	2010	Catalase(-/-) cells were readily oxidized by exogenous H(2)O(2).	Water	55-60	catalase	Mus musculus	0-8
19969073-7	2010	Cells lacking both catalase and Gpx1 were more sensitive to exogenous H(2)O(2) than cells lacking only catalase.	Water	70-75	catalase	Mus musculus	19-27
20149227-9	2010	Contrary to humans and some rodents, intrachromosomal duplicates of zebrafish AQP8 were water and urea permeable, while the genomic duplicate only transported water.	Water	159-164	aquaporin 8a, tandem duplicate 1	Danio rerio	78-82
19916573-5	2010	In the present study, the stability of ARP p18INK4c (p18) and fifty p18 fragments was investigated by all- atomic molecular dynamics (MD) simulations in explicit water on a ~3.3 micro- seconds timescale.	Water	162-167	cyclin dependent kinase inhibitor 2C	Homo sapiens	43-46
19996160-1	2010	Vasopressin is a peptide hormone that regulates renal water excretion in part through its actions on the collecting duct.	Water	54-59	arginine vasopressin	Rattus norvegicus	0-11
19306058-1	2010	Aquaporin1 (AQP1) is a water channel protein that facilitates water flux across cell membranes.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	12-16
20058916-1	2010	The air-water interface in atmospheric water films of aerosols and hydrometeors (fog, mist, ice, rain, and snow) presents an important surface for the adsorption and reaction of many organic trace gases and gaseous reactive oxidants (hydroxyl radical (OH(.	Water	8-13	zinc finger protein, FOG family member 1	Homo sapiens	81-84
20058916-1	2010	The air-water interface in atmospheric water films of aerosols and hydrometeors (fog, mist, ice, rain, and snow) presents an important surface for the adsorption and reaction of many organic trace gases and gaseous reactive oxidants (hydroxyl radical (OH(.	Water	39-44	zinc finger protein, FOG family member 1	Homo sapiens	81-84
19800338-2	2010	The bulk of sodium and water absorption in the intestine is mediated by Na(+)/H(+) exchanger 3 (NHE3), located in the luminal membrane of enterocytes.	Water	23-28	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	72-94
19800338-2	2010	The bulk of sodium and water absorption in the intestine is mediated by Na(+)/H(+) exchanger 3 (NHE3), located in the luminal membrane of enterocytes.	Water	23-28	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	96-100
20129098-2	2010	In this study, the oxidation of cholesterol by Abeta/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer.	Water	158-163	amyloid beta precursor protein	Homo sapiens	47-52
20063900-5	2010	This suggests that the increased level of water transport following osmotic change may be due a phosphorylation-dependent increase in the level of AQP1 trafficking resulting in membrane localization.	Water	42-47	aquaporin 1 (Colton blood group)	Homo sapiens	147-151
21031143-4	2010	Monte Carlo simulations of ethanol, benzene, and N-methylacetamide in SSDQO with SPC/E moments showed the water structure was as good as in SPC/E.	Water	106-111	proline rich protein gene cluster	Homo sapiens	81-84
21031143-4	2010	Monte Carlo simulations of ethanol, benzene, and N-methylacetamide in SSDQO with SPC/E moments showed the water structure was as good as in SPC/E.	Water	106-111	proline rich protein gene cluster	Homo sapiens	140-143
20058869-1	2010	We use molecular dynamics simulations of the SPC-E model of liquid water to derive probability distributions for water density fluctuations in probe volumes of different shapes and sizes, both in the bulk as well as near hydrophobic and hydrophilic surfaces.	Water	67-72	proline rich protein gene cluster	Homo sapiens	45-48
20058869-1	2010	We use molecular dynamics simulations of the SPC-E model of liquid water to derive probability distributions for water density fluctuations in probe volumes of different shapes and sizes, both in the bulk as well as near hydrophobic and hydrophilic surfaces.	Water	113-118	proline rich protein gene cluster	Homo sapiens	45-48
19937002-1	2010	A commercially available screen-printed carbon electrode coated with an ex situ deposited bismuth film (BiSPCE) has been applied to the determination of Pb(II) and Zn(II) ions in tap water (Barcelona water distribution network) by means of stripping voltammetry (SV) and stripping chronopotentiometry (SCP).	Water	183-188	submaxillary gland androgen regulated protein 3B	Homo sapiens	153-159
19937002-1	2010	A commercially available screen-printed carbon electrode coated with an ex situ deposited bismuth film (BiSPCE) has been applied to the determination of Pb(II) and Zn(II) ions in tap water (Barcelona water distribution network) by means of stripping voltammetry (SV) and stripping chronopotentiometry (SCP).	Water	200-205	submaxillary gland androgen regulated protein 3B	Homo sapiens	153-159
19306058-1	2010	Aquaporin1 (AQP1) is a water channel protein that facilitates water flux across cell membranes.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	0-10
20050827-1	2010	CFTR (cystic fibrosis transmembrane conductance regulator) is a cAMP-activated chloride channel that regulates electrolyte and water transport.	Water	127-132	CF transmembrane conductance regulator	Homo sapiens	0-4
20050827-1	2010	CFTR (cystic fibrosis transmembrane conductance regulator) is a cAMP-activated chloride channel that regulates electrolyte and water transport.	Water	127-132	CF transmembrane conductance regulator	Homo sapiens	6-57
19796672-1	2010	Recently, considerable evidence has been accumulated to support the novel view that water homeostasis in the inner ear is regulated via the vasopressin-aquaporin 2 (VP-AQP2) system in the same fashion as in the kidney.	Water	84-89	arginine vasopressin	Homo sapiens	140-151
19796672-4	2010	In the present study, the localizations of AQP-1, -2, -3, -4, -5, -7, -8, -9, and vasopressin type 2 receptor (V2-R) in the stria vascularis (SV) were molecular biologically and immunohistochemically examined to evaluate the role of the AQP water channel system in water homeostasis of the SV.	Water	241-246	arginine vasopressin receptor 2	Homo sapiens	111-115
19796672-9	2010	From the present results, water flux in the SV is thought to be regulated at the level of the basal cells by vasopressin.	Water	26-31	arginine vasopressin	Homo sapiens	109-120
19796672-10	2010	Furthermore, such a distribution of AQP-2, -3, and V2-R suggests that VP-AQP-2 mediated water transport might work actively in the basal cells from perilymph towards endolymph containing AQP-1, -7 and -9.	Water	88-93	arginine vasopressin receptor 2	Homo sapiens	51-55
19796672-10	2010	Furthermore, such a distribution of AQP-2, -3, and V2-R suggests that VP-AQP-2 mediated water transport might work actively in the basal cells from perilymph towards endolymph containing AQP-1, -7 and -9.	Water	88-93	aquaporin 1 (Colton blood group)	Homo sapiens	187-203
20725563-0	2010	Allergy to a hot tub water treatment chemical: an unexpectedly common cause of generalized dermatitis in men.	Water	21-26	TUB bipartite transcription factor	Homo sapiens	17-20
19916574-0	2010	A molecular dynamics study of human defensins HBD-1 and HNP-3 in water.	Water	65-70	defensin beta 1	Homo sapiens	46-51
19906645-3	2010	We present here a thermodynamic, structural, and molecular dynamics simulation study of the interaction of p41 with Abl-SH3 and a set of mutants designed to alter the water-mediated interaction network.	Water	167-172	mitogen-activated protein kinase 1	Homo sapiens	107-110
20086120-12	2010	The presence and observed dynamics of the AQP-8b isoform specifically in intestinal sections suggest that this is a key water channel responsible for water uptake in the intestinal tract of seawater salmonids.	Water	120-125	aquaporin-8	Salmo salar	42-48
20086120-12	2010	The presence and observed dynamics of the AQP-8b isoform specifically in intestinal sections suggest that this is a key water channel responsible for water uptake in the intestinal tract of seawater salmonids.	Water	150-155	aquaporin-8	Salmo salar	42-48
19903491-2	2010	In the lungs, absence or dysfunction of CFTR results in altered epithelial salt and water transport eventuating in impaired mucociliary clearance, chronic infection and inflammation, and tissue damage.	Water	84-89	CF transmembrane conductance regulator	Homo sapiens	40-44
19479737-6	2010	The directional and average water diffusivities from OPLS-AA and AMBER03 along with SPC/E model match fairly well with experimental data.	Water	28-33	proline rich protein gene cluster	Homo sapiens	84-87
19933270-4	2010	Exposure of neutrophils or HEK 293 cells to H(2)O(2) was associated with reduced binding between phosphorylated I kappaB alpha and SCF(beta-TrCP) but no change in the composition of the SCF(beta-TrCP) complex.	Water	44-50	NFKB inhibitor alpha	Homo sapiens	112-126
19705128-4	2010	Expressions and immunolocalizations of aquaporin-1 (AQP1), a member of the water-selective channel termed AQP, were also investigated in the intestine.	Water	75-80	aquaporin-1	Tursiops truncatus	39-50
19705128-4	2010	Expressions and immunolocalizations of aquaporin-1 (AQP1), a member of the water-selective channel termed AQP, were also investigated in the intestine.	Water	75-80	aquaporin-1	Tursiops truncatus	52-56
19705128-8	2010	These data suggest that AQP1 is a channel protein responsible for water absorption in the small intestine of dolphins.	Water	66-71	aquaporin-1	Tursiops truncatus	24-28
20338844-8	2010	Using chemical modification and different SGLT1 mutants, a relationship was found between the cationic leak current and the passive water permeability suggesting that water and cations may share a common pathway through the cotransporter.	Water	132-137	solute carrier family 5 member 1	Homo sapiens	42-47
20338844-8	2010	Using chemical modification and different SGLT1 mutants, a relationship was found between the cationic leak current and the passive water permeability suggesting that water and cations may share a common pathway through the cotransporter.	Water	167-172	solute carrier family 5 member 1	Homo sapiens	42-47
20038113-1	2010	The Fourier transform infrared-attenuated total reflectance (FT-IR-ATR) technique has been used to detect and quantify the following volatile organic compounds (VOCs) in water: 1,1,1,2-tetrachloroethane, 1,1,2,2-tetrachloroethane, styrene, and tetrachloroethylene, among which the first three compounds were investigated at parts per million levels for the first time.	Water	170-175	ATR serine/threonine kinase	Homo sapiens	67-70
19421988-2	2010	The SPC water model (Berendsen, H. J. C., Postma, J. P. M., van Gunsteren, W. F., Hermans, P. A. K. J., Dixon, R., Cornell, W., Fox, T., Chipot, C., Pohorille, A.	Water	8-13	proline rich protein gene cluster	Homo sapiens	4-7
19610096-3	2010	In response to injury, two additional aquaporins, AQP1 and AQP9, can be detected in astrocytes, yet neither is found in cultured astrocytes, and therefore their contribution to astrocyte water uptake and biology is poorly investigated.	Water	187-192	aquaporin 1 (Colton blood group)	Homo sapiens	50-54
19610096-3	2010	In response to injury, two additional aquaporins, AQP1 and AQP9, can be detected in astrocytes, yet neither is found in cultured astrocytes, and therefore their contribution to astrocyte water uptake and biology is poorly investigated.	Water	187-192	aquaporin 9	Homo sapiens	59-63
19546036-9	2010	Under the optimum loading, washing and eluting conditions, the IAM specifically retained deltamethrin, flumethrin, flucythrinate and cis/trans permethrin, which were further baseline separated by C18 column using acetonitrile-water (83:17, V/V) as the mobile phase at a flow rate of 1.0mL/min.	Water	226-231	Bardet-Biedl syndrome 9	Homo sapiens	196-199
19846107-2	2010	In the phase behavior study, it is pointed out that the formation of the discontinuous cubic phase (I(1)) is not common in all nonionic surfactant systems; however, a cubic phase (I(1)) with oil-swollen micelles or a cubic phase microemulsion is found in the water/C(16)EO(6)/dodecane system, which can solubilize large amount of oil.	Water	259-264	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	99-104
19863091-4	2010	The TIP3P and SPC/E water models show very similar dynamical correlations in the TPE fluctuations on frequency scales greater than 0.1 cm(-1).	Water	20-25	proline rich protein gene cluster	Homo sapiens	14-17
20017469-3	2010	In this study, we synthesized the stable, water-soluble receptor 1a as a structural mimic of the active site in UDG.	Water	42-47	uracil DNA glycosylase	Homo sapiens	112-115
19864301-1	2010	Angiotensin II (ANG II) stimulates proximal tubule (PT) sodium and water reabsorption.	Water	67-72	angiotensinogen	Rattus norvegicus	0-14
19968275-1	2010	In the present work, the formation and stabilization of gold nanoparticles in a one-pot water-based synthesis has been achieved in the presence of a four-arm, star-shaped polyoxyethyelene-polyoxypropylene (PEO-PPO) block copolymer, Tetronic T904, which acts as both reductant and stabilizer.	Water	88-93	protoporphyrinogen oxidase	Homo sapiens	210-213
21188246-2	2010	Tetrahydrobiopterin (BH(4)) is an essential cofactor of endothelial NO synthase (eNOS) to produce NO, whereas dihydrobiopterin (BH(2)) can shift the eNOS product profile from NO to superoxide, which is further converted to hydrogen peroxide (H(2)O(2)) and cause I/R injury.	Water	242-247	nitric oxide synthase 3	Homo sapiens	81-85
21188246-6	2010	In conclusion, these results suggest that promoting eNOS coupling to produce NO and decrease H(2)O(2) may be a key mechanism to restore postreperfused organ function during early reperfusion.	Water	93-98	nitric oxide synthase 3	Homo sapiens	52-56
20014840-6	2010	The three oxidation states present in the range of water stability are At(-I), At(+I), and At(+III) and exist as At(-), At(+), and AtO(+), respectively, in the 1-2 pH range.	Water	51-56	splicing factor-like protein	Arabidopsis thaliana	131-134
19947643-5	2010	There are two ways in which the undissociated form of a bis-chelated complex can interact with transferrin, one "specific" when the carrier possesses a carboxylate group and behaves like a synergistic anion, and another "non-specific" when an imidazole nitrogen of a histidine residue from hTf replaces an equatorially coordinated water molecule giving rise to a ternary species with cis-octahedral geometry and cis-VO(carrier)(2)(hTf) stoichiometry.	Water	331-336	transferrin	Homo sapiens	95-106
19864301-1	2010	Angiotensin II (ANG II) stimulates proximal tubule (PT) sodium and water reabsorption.	Water	67-72	angiotensinogen	Rattus norvegicus	16-22
19864301-8	2010	In summary, in response to 20 min ANG II in the absence of a change in BP or GFR, multiple proteins traffic into the PT brush-border microvilli where they likely contribute to the rapid increase in PT salt and water reabsorption.	Water	210-215	angiotensinogen	Rattus norvegicus	34-40
20024649-11	2010	This study shows the usefulness of HG5LN-hPXR cells to detect PXR-active compounds in water samples, and further investigation will be necessary to identify the detected active compounds.	Water	86-91	nuclear receptor subfamily 1 group I member 2	Homo sapiens	42-45
20024649-5	2010	Furthermore, we detected potent PXR activity in two types of water samples: passive polar organic compounds integrative sampler (POCIS) extracts from a river moderately impacted by agricultural and urban inputs and three effluents from sewage treatment works (STW).	Water	61-66	nuclear receptor subfamily 1 group I member 2	Homo sapiens	32-35
21029011-1	2010	Accumulated studies reported that the natruretic dopamine (DA) and the anti-natruretic angiotensin II (Ang II) represent an important mechanism to regulate renal Na(+) and water excretion through intracellular secondary messengers to inhibit or activate renal proximal tubule (PT) Na(+), K(+)-ATPase (NKA).	Water	172-177	angiotensinogen	Homo sapiens	87-101
20024649-6	2010	Fractionation of POCIS samples showed the highest PXR activity in the less polar fraction, while in the effluents, PXR activity was mainly associated with the dissolved water phase.	Water	169-174	nuclear receptor subfamily 1 group I member 2	Homo sapiens	115-118
20953057-4	2010	In a sample solution of tryptophan and glucose in the presence of human serum albumin, the improved STD experiment only succeeded in selective detections of the bound ligand signals, even resonating close to water.	Water	208-213	albumin	Homo sapiens	72-85
21079391-0	2010	Upregulation of lipogenesis and protein tyrosine phosphatase-1B expression in the liver of Wistar rats with metabolic syndrome chronically induced by drinking sucrose water.	Water	167-172	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	32-63
21079391-7	2010	The upregulation of de novo lipogenesis in the liver of the sucrose water-treated rats was demonstrated by an increased activity of enzymes, mRNA levels of lipogenic proteins, and nuclear levels of SREBP-1c and ChREBP.	Water	68-73	MLX interacting protein-like	Rattus norvegicus	211-217
21079391-8	2010	Moreover, in the sucrose water-treated rats, protein levels of PTP-1B were significantly increased in liver and skeletal muscle but decreased in adipose tissue.	Water	25-30	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	63-69
21079391-9	2010	CONCLUSION: The susceptibility of Wistar rats to sucrose water-induced MS is associated with the transactivation of SREBP-1c and ChREBP in the liver, and PTP-1B is involved in the upregulation of de novo lipogenesis in the liver and the pathology of systemic insulin resistance in rats with MS chronically induced by drinking sucrose water.	Water	57-62	MLX interacting protein-like	Rattus norvegicus	129-135
21079391-9	2010	CONCLUSION: The susceptibility of Wistar rats to sucrose water-induced MS is associated with the transactivation of SREBP-1c and ChREBP in the liver, and PTP-1B is involved in the upregulation of de novo lipogenesis in the liver and the pathology of systemic insulin resistance in rats with MS chronically induced by drinking sucrose water.	Water	57-62	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	154-160
21079391-9	2010	CONCLUSION: The susceptibility of Wistar rats to sucrose water-induced MS is associated with the transactivation of SREBP-1c and ChREBP in the liver, and PTP-1B is involved in the upregulation of de novo lipogenesis in the liver and the pathology of systemic insulin resistance in rats with MS chronically induced by drinking sucrose water.	Water	334-339	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	154-160
20024649-11	2010	This study shows the usefulness of HG5LN-hPXR cells to detect PXR-active compounds in water samples, and further investigation will be necessary to identify the detected active compounds.	Water	86-91	nuclear receptor subfamily 1 group I member 2	Homo sapiens	41-45
19495753-0	2010	A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts.	Water	2-7	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	78-110
19495753-2	2010	METHODS: A novel camptothecin analog that is effective against breast cancer resistance protein (BCRP)-positive cells was screened, and a water soluble prodrug was generated.	Water	138-143	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	63-95
19495753-2	2010	METHODS: A novel camptothecin analog that is effective against breast cancer resistance protein (BCRP)-positive cells was screened, and a water soluble prodrug was generated.	Water	138-143	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	97-101
19772916-7	2010	In fact, U46619 caused [(3)H]H(2)O influx into the cells, which was inhibited by p115-RGS, C3 toxin, EIPA, mercury chloride and phloretin.	Water	29-34	paired like homeodomain 2	Homo sapiens	86-89
19917512-0	2010	Phenanthrene and 2,2",5,5"-PCB sorption by several soils from methanol-water solutions: the effect of weathering and solute structure.	Water	71-76	pyruvate carboxylase	Homo sapiens	27-30
21029011-1	2010	Accumulated studies reported that the natruretic dopamine (DA) and the anti-natruretic angiotensin II (Ang II) represent an important mechanism to regulate renal Na(+) and water excretion through intracellular secondary messengers to inhibit or activate renal proximal tubule (PT) Na(+), K(+)-ATPase (NKA).	Water	172-177	angiotensinogen	Homo sapiens	103-109
19864112-12	2010	CONCLUSION: Variations in the AQP4 and the KCNJ10/KCNJ9 region are likely to be associated with TLE, particularly TLE-FS, supporting the suggestion that perturbations of water and K(+) transport are involved in the etiopathogenesis of TLE.	Water	170-175	potassium inwardly rectifying channel subfamily J member 9	Homo sapiens	50-55
19566387-1	2010	BACKGROUND: Poly (ethylene oxide) (PEO) is nonionic, water soluble, and highly hydrophilic polymer with well-established applications in mucoadhesives, water-soluble films, rheology control agents and thickeners, and additives in pharmaceutical products.	Water	53-58	twinkle mtDNA helicase	Homo sapiens	35-38
19566387-1	2010	BACKGROUND: Poly (ethylene oxide) (PEO) is nonionic, water soluble, and highly hydrophilic polymer with well-established applications in mucoadhesives, water-soluble films, rheology control agents and thickeners, and additives in pharmaceutical products.	Water	152-157	twinkle mtDNA helicase	Homo sapiens	35-38
20043279-8	2010	This study reveals that CAP1 plays a crucial role in the regulation of ENaC-mediated alveolar sodium and water transport and in mouse lung fluid balance.	Water	105-110	CAP, adenylate cyclase-associated protein 1 (yeast)	Mus musculus	24-28
20108263-0	2010	ACE applied to the quantitative characterization of benzo-18-crown-6-ether binding with alkali metal ions in a methanol-water solvent system.	Water	120-125	angiotensin I converting enzyme	Homo sapiens	0-3
20108263-1	2010	ACE was applied to the quantitative evaluation of noncovalent binding interactions between benzo-18-crown-6-ether (B18C6) and several alkali metal ions, Li(+), Na(+), K(+), Rb(+) and Cs(+), in a mixed binary solvent system, methanol-water (50/50 v/v).	Water	233-238	angiotensin I converting enzyme	Homo sapiens	0-3
19661221-3	2010	METHODS: The authors tested whether intravitreal application of the selective, water-soluble, toll-like receptor 2 agonist Pam(3)Cys can delay axotomized RGC cell death and stimulate the regeneration of axons using an in vitro and in vivo paradigm.	Water	79-84	toll like receptor 2	Homo sapiens	94-114
19672816-2	2010	According to the large body of clinical evidence, vasopressin has an impact on salt and water imbalance, hyponatremia, and subsequent renal insufficiency - the most common and destructive co-morbidity of patients afflicted with chronic heart failure.	Water	88-93	arginine vasopressin	Homo sapiens	50-61
20202240-9	2010	The lowest bladder pressure at which HIF-1alpha was up regulated, was detected at detrusor pressure Qmax (PdetQmax) = 60 cm H2O.	Water	124-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
21043431-2	2010	SPC/E water is simulated in confinement between two infinite planar surfaces that differ in their physical topology: one is smooth and the other one is physically rough on a sub-nanometre length scale.	Water	6-11	proline rich protein gene cluster	Homo sapiens	0-3
20302130-3	2010	The products are orthorhombic Ce2 O(CO3)2.H2O with valence III by using homogeneous precipitation method directly.	Water	42-45	carboxylesterase 2	Homo sapiens	30-33
22081588-2	2010	Via the bloodstream, vasopressin reaches the collecting duct cells in the kidney, where the water channel Aquaporin-2 (AQP2) is expressed.	Water	92-97	arginine vasopressin	Homo sapiens	21-32
20111742-4	2010	Since aquaporin-6 is permeable to both water and anions, these results suggest its possible involvement in regulating OHC motility, directly through modulation of water and chloride flow or by changing mechanical compliance in Deiters" cells.	Water	39-44	aquaporin 6	Mus musculus	6-17
20507711-7	2010	The anionic co-polymerization of gamma-benzyl-L-glutamate N-carboxyanhydride (BLG-NCA) using PEG-g-PEI as a macro-initiator was carried out, followed by aminolysis with 2-dimethylaminoethylamine to obtain the target water-soluble tri-block co-polymer.	Water	216-221	CEA cell adhesion molecule 4	Homo sapiens	82-85
21278915-0	2010	Effects of Water Placement on Predictions of Binding Affinities for p38alpha MAP Kinase Inhibitors.	Water	11-16	mitogen-activated protein kinase 14	Homo sapiens	68-76
20390867-0	2010	Environmental factors influencing remediation of TNT-contaminated water and soil with nanoscale zero-valent iron particles.	Water	66-71	chromosome 16 open reading frame 82	Homo sapiens	49-52
20390867-1	2010	This study evaluated the application of nanoscale metallic particles (nanoscale zero-valent iron (nZVI) particles) in the remediation of TNT in contaminated water and soil samples.	Water	157-162	chromosome 16 open reading frame 82	Homo sapiens	137-140
20390867-4	2010	The optimum dosage of nZVI for degradation of 10 mg/L TNT in the contaminated water was 2000 mg/L (w/v) at a reaction time 20 min.	Water	78-83	chromosome 16 open reading frame 82	Homo sapiens	54-57
20390867-9	2010	Results of this study indicate it is feasible to use nZVI for the remediation of TNT-contaminated water and soil samples as a pre-treatment step however secondary treatments such as phyto-remediation or other biological processes may be needed to remove any residue or intermediate products of TNT degradation.	Water	98-103	chromosome 16 open reading frame 82	Homo sapiens	81-84
20606409-8	2010	AVPR2 stimulation increases retention of water by increasing cyclic AMP.	Water	41-46	arginine vasopressin receptor 2	Homo sapiens	0-5
20164597-7	2010	The cognitive functions in transgenic McGill-R-Thy1-APP rats, as assessed using the Morris water maze task, were found already altered as early as at 3 months of age, when no CNS plaques are yet present.	Water	91-96	Thy-1 cell surface antigen	Rattus norvegicus	47-51
19760484-0	2010	Centrally administered ghrelin potently inhibits water intake induced by angiotensin II and hypovolemia in rats.	Water	49-54	angiotensinogen	Rattus norvegicus	73-87
19760484-3	2010	In this study, we examined the effect of intracerebroventricular (icv) injection of ghrelin on angiotensin II (AII)-induced water intake in rats.	Water	124-129	angiotensinogen	Rattus norvegicus	95-109
19760484-3	2010	In this study, we examined the effect of intracerebroventricular (icv) injection of ghrelin on angiotensin II (AII)-induced water intake in rats.	Water	124-129	angiotensinogen	Rattus norvegicus	111-114
19760484-5	2010	Water intake induced by the icv injection of AII or ip injection of PEG was significantly reduced after icv injection of ghrelin, although food intake was stimulated by the hormone.	Water	0-5	angiotensinogen	Rattus norvegicus	45-48
20111742-4	2010	Since aquaporin-6 is permeable to both water and anions, these results suggest its possible involvement in regulating OHC motility, directly through modulation of water and chloride flow or by changing mechanical compliance in Deiters" cells.	Water	163-168	aquaporin 6	Mus musculus	6-17
19847155-9	2010	If future studies show that this association is causal, then drinking more water or pharmacological intervention to decrease plasma vasopressin may have beneficial effects on the kidney, especially in the elderly.	Water	75-80	arginine vasopressin	Homo sapiens	132-143
19812234-1	2010	AQP11 is one of the latest aquaporin (AQP) family members found, which differs from the other AQPs by its intracellular localisation and unusual water pore nucleotides with unclear function.	Water	145-150	aquaporin 11	Mus musculus	0-5
20057381-3	2010	The SODs convert superoxide radical into hydrogen peroxide and molecular oxygen, whereas the catalase and peroxidases convert hydrogen peroxide into water.	Water	149-154	catalase	Homo sapiens	93-101
20004137-4	2010	The Mn1 atom is coordinated with one Schiff base ligand, one water molecule and one chloride anion, forming a six-coordination number.	Water	61-66	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	4-7
19910022-4	2010	However, the methodology used to assess exposure of pregnant women in these studies had serious limitations, particularly in relation to determining CBP presence in the subject"s tap water.	Water	183-188	CREB binding protein	Homo sapiens	149-152
19910022-5	2010	The purpose of this paper is to critically review of methods used to evaluate the CBP presence in a subject"s tap water for exposure assessment purposes in epidemiological studies focused on adverse reproductive outcomes and CBPs in drinking water.	Water	114-119	CREB binding protein	Homo sapiens	82-85
19910022-5	2010	The purpose of this paper is to critically review of methods used to evaluate the CBP presence in a subject"s tap water for exposure assessment purposes in epidemiological studies focused on adverse reproductive outcomes and CBPs in drinking water.	Water	242-247	CREB binding protein	Homo sapiens	82-85
20023872-4	2009	The absence of acetate in reaction mixtures containing Co(II) and Mn(II) led to mononuclear complexes, with water ligands completing the coordination spheres of the metal ions, even in the presence of large excess of the metal ions.	Water	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
19695772-10	2009	Results suggest higher inputs of DOC and DBP precursors from forest watersheds into source water may result in a warmer environment.	Water	68-73	D-box binding PAR bZIP transcription factor	Homo sapiens	41-44
19709813-8	2009	The optode was successfully used for measuring Pb(II) ions in different water samples and in SRM sample.	Water	72-77	submaxillary gland androgen regulated protein 3B	Homo sapiens	47-53
20059115-8	2009	Finally, the Raman susceptibility of sugar/water solutions and the calculated VDOS of water in the different lysozyme solutions confirm that sugars induce a significant strengthening of the hydrogen bond network of water that may stabilize proteins at high temperatures.	Water	86-91	lysozyme	Homo sapiens	109-117
19924849-1	2009	Photon correlation spectroscopy and circular dichroism have been used to study the role of hydration in the structure and thermostability of the model protein lysozyme in water-glycerol mixtures.	Water	171-176	lysozyme	Homo sapiens	159-167
20799617-2	2010	In contrast to the generally accepted belief that the secretory vesicle membrane is totally incorporated into the plasma membrane during cell secretion, it has been shown that secretory vesicles transiently dock and fuse with the porosome base via SNARE proteins to expel vesicular contents under intravesicular pressure which is generated by active transport of water through water channels located at the secretory vesicle membrane.	Water	363-368	Polykaryocytosis inducer	Homo sapiens	216-220
20799617-2	2010	In contrast to the generally accepted belief that the secretory vesicle membrane is totally incorporated into the plasma membrane during cell secretion, it has been shown that secretory vesicles transiently dock and fuse with the porosome base via SNARE proteins to expel vesicular contents under intravesicular pressure which is generated by active transport of water through water channels located at the secretory vesicle membrane.	Water	377-382	Polykaryocytosis inducer	Homo sapiens	216-220
20054444-5	2009	Blocking the effects of arginin vasopressin on V(2) receptors produces aquaresis--the electrolyte-sparing excretion of water--an ideal approach to correct hypervolemic hyponatremia.	Water	119-124	arginine vasopressin	Homo sapiens	32-43
20059055-4	2009	In particular, results for the simple point charge/extended (SPC/E) water model treated with spherically truncated Coulomb interactions suggested by local molecular field theory [J. M. Rodgers and J. D. Weeks, Proc.	Water	68-73	proline rich protein gene cluster	Homo sapiens	61-64
20059055-12	2009	We show that the energy and pressure of spherically truncated bulk SPC/E water are easily corrected using exact second-moment-like conditions on long-ranged structure.	Water	73-78	proline rich protein gene cluster	Homo sapiens	67-70
20059115-7	2009	These results suggest that sugars stiffen the environment experienced by lysozyme atoms, thereby counteracting the softening of protein vibrational modes upon denaturation, observed at high temperature in the Raman susceptibility of the lysozyme/water solution and in the computed VDOS of unfolded lysozyme in water.	Water	246-251	lysozyme	Homo sapiens	73-81
20059115-7	2009	These results suggest that sugars stiffen the environment experienced by lysozyme atoms, thereby counteracting the softening of protein vibrational modes upon denaturation, observed at high temperature in the Raman susceptibility of the lysozyme/water solution and in the computed VDOS of unfolded lysozyme in water.	Water	246-251	lysozyme	Homo sapiens	237-245
20059115-7	2009	These results suggest that sugars stiffen the environment experienced by lysozyme atoms, thereby counteracting the softening of protein vibrational modes upon denaturation, observed at high temperature in the Raman susceptibility of the lysozyme/water solution and in the computed VDOS of unfolded lysozyme in water.	Water	246-251	lysozyme	Homo sapiens	237-245
20059115-7	2009	These results suggest that sugars stiffen the environment experienced by lysozyme atoms, thereby counteracting the softening of protein vibrational modes upon denaturation, observed at high temperature in the Raman susceptibility of the lysozyme/water solution and in the computed VDOS of unfolded lysozyme in water.	Water	310-315	lysozyme	Homo sapiens	73-81
20059115-8	2009	Finally, the Raman susceptibility of sugar/water solutions and the calculated VDOS of water in the different lysozyme solutions confirm that sugars induce a significant strengthening of the hydrogen bond network of water that may stabilize proteins at high temperatures.	Water	86-91	lysozyme	Homo sapiens	109-117
19924868-2	2009	In this paper, we present the first data on time-resolved fluorescence anisotropy study on the interaction between a water-soluble cationic porphyrin H(2)TMPyP4 and four distinct G-quadruplex DNAs, that is, AG(3)(T(2)AG(3))(3), thrombin-binding aptamer (TBA), (G(4)T(4)G(4))2, and (TG(4)T)4.	Water	117-122	coagulation factor II, thrombin	Homo sapiens	228-236
19857466-4	2009	In vitro and ex vivo experiments from several laboratories have confirmed the water permeability function of AQP0.	Water	78-83	major intrinsic protein of lens fiber	Mus musculus	109-113
19857466-6	2009	A possible explanation is AQP0 may perform unique function/s besides being a water pore.	Water	77-82	major intrinsic protein of lens fiber	Mus musculus	26-30
19896845-0	2009	Incorporation of water-solubilizing groups in pyrazolopyrimidine mTOR inhibitors: discovery of highly potent and selective analogs with improved human microsomal stability.	Water	17-22	mechanistic target of rapamycin kinase	Homo sapiens	65-69
19896845-1	2009	A series of highly potent and selective pyrazolopyrimidine mTOR inhibitors which contain water-solubilizing groups attached to the 6-arylureidophenyl moiety have been prepared.	Water	89-94	mechanistic target of rapamycin kinase	Homo sapiens	59-63
19923702-4	2009	CAM contains bi-layers of L-cysteic acid molecules separated by water molecules which form donor interactions to the bi-layers above and below.	Water	64-69	calmodulin 3	Homo sapiens	0-3
19646978-5	2009	Drinking water with 0.1% EGCG significantly decreased the serum levels of both aspartate aminotransferase and alanine aminotransferase raised by CCl4, thus indicating an improvement of liver injury.	Water	9-14	C-C motif chemokine ligand 4	Rattus norvegicus	145-149
19948673-2	2009	In the kidney, angiotensin II exerts its effects to conserve salt and water through a combination of the hemodynamic control of renal blood flow and glomerular filtration rate and tubular epithelial cell sodium chloride and water transport mechanisms.	Water	70-75	angiotensinogen	Homo sapiens	15-29
19948673-2	2009	In the kidney, angiotensin II exerts its effects to conserve salt and water through a combination of the hemodynamic control of renal blood flow and glomerular filtration rate and tubular epithelial cell sodium chloride and water transport mechanisms.	Water	224-229	angiotensinogen	Homo sapiens	15-29
19776175-10	2009	These findings strongly support an important role of angiotensin II in the pathophysiology of renal water and sodium retention associated with HF.	Water	100-105	angiotensinogen	Rattus norvegicus	53-67
19776169-10	2009	Thus ANG II increases AQP1 expression in vitro and in vivo via direct interaction with the AT(1) receptor, providing an important regulatory mechanism to link PT water reabsorption to body fluid homeostasis via the renin-angiotensin system.	Water	162-167	angiotensinogen	Rattus norvegicus	5-11
19918931-1	2009	Changes in gene expression of TGF-beta family members and their receptors in response to treatment with H(2)O(2) and a calcium ionophore, A23187, were examined in C2C12 myoblasts and myotubes.	Water	104-109	transforming growth factor beta 1	Homo sapiens	30-38
20009338-0	2009	Silica gel chemically modified with ethyl-2-benzothiazolylacetate for selective extraction of Pb(II) and Cu(II) from real water samples.	Water	122-127	submaxillary gland androgen regulated protein 3B	Homo sapiens	94-111
20009338-9	2009	This modified silica gel was applied to preconcentrate Pb(II) and Cu(II) from spiked pond water, tap water and drinking water, giving high accuracy and precision.	Water	90-95	submaxillary gland androgen regulated protein 3B	Homo sapiens	55-72
20009338-9	2009	This modified silica gel was applied to preconcentrate Pb(II) and Cu(II) from spiked pond water, tap water and drinking water, giving high accuracy and precision.	Water	101-106	submaxillary gland androgen regulated protein 3B	Homo sapiens	55-72
19843077-0	2009	QM/MM study of epitope peptides binding to HLA-A*0201: the roles of anchor residues and water.	Water	88-93	major histocompatibility complex, class I, A	Homo sapiens	43-48
20187384-8	2009	However, the areas of confined water with nitrate concentrations of 5-10 mg x L(-1), 10-15 mg x L(-1) and 15-20 mg x L(-1) were increased by 28.01%, 9.33%, and 0.48% respectively, while the areas of NO3- -N concentration (0-5 mg x L(-1)) was decreased by 37.82%.	Water	31-36	NBL1, DAN family BMP antagonist	Homo sapiens	199-202
19843077-4	2009	We believe that this work is helpful for elucidating the roles of anchor residues and water molecules in peptides recognized and bound by HLA-A*0201.	Water	86-91	major histocompatibility complex, class I, A	Homo sapiens	138-143
19747560-5	2009	PDIA3 was significantly increased in the liver of Atlantic salmon exposed to hyperoxic water during smoltification.	Water	87-92	protein disulfide-isomerase A3	Salmo salar	0-5
21468184-6	2009	Activation of sympathetic nervous system, renin-angiotensin-aldosterone system and non-osmotic vasopressin release stimulate the renal tubular reabsorption of sodium and water.	Water	170-175	renin	Homo sapiens	42-47
21468184-6	2009	Activation of sympathetic nervous system, renin-angiotensin-aldosterone system and non-osmotic vasopressin release stimulate the renal tubular reabsorption of sodium and water.	Water	170-175	arginine vasopressin	Homo sapiens	95-106
20187384-9	2009	The NO3- -N concentration in confined water was significantly negative related to groundwater depth for the two period, we found an increasing trend of NO3- -N concentration in the deeper confined water from 2002 to 2007.	Water	38-43	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
20187384-9	2009	The NO3- -N concentration in confined water was significantly negative related to groundwater depth for the two period, we found an increasing trend of NO3- -N concentration in the deeper confined water from 2002 to 2007.	Water	88-93	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
20738681-5	2009	The Aqp1b belongs to a teleost-specific subfamily of water-selective aquaporins, similar to mammalian aquaporin-1 (AQP1) that has possibly evolved by duplication of a common ancestor and further neofunctionalization in oocytes of marine teleosts for water uptake.	Water	53-58	aquaporin 1 (Colton blood group)	Homo sapiens	102-113
20738681-5	2009	The Aqp1b belongs to a teleost-specific subfamily of water-selective aquaporins, similar to mammalian aquaporin-1 (AQP1) that has possibly evolved by duplication of a common ancestor and further neofunctionalization in oocytes of marine teleosts for water uptake.	Water	53-58	aquaporin 1 (Colton blood group)	Homo sapiens	115-119
20738681-5	2009	The Aqp1b belongs to a teleost-specific subfamily of water-selective aquaporins, similar to mammalian aquaporin-1 (AQP1) that has possibly evolved by duplication of a common ancestor and further neofunctionalization in oocytes of marine teleosts for water uptake.	Water	250-255	aquaporin 1 (Colton blood group)	Homo sapiens	102-113
20738681-5	2009	The Aqp1b belongs to a teleost-specific subfamily of water-selective aquaporins, similar to mammalian aquaporin-1 (AQP1) that has possibly evolved by duplication of a common ancestor and further neofunctionalization in oocytes of marine teleosts for water uptake.	Water	250-255	aquaporin 1 (Colton blood group)	Homo sapiens	115-119
19617274-2	2009	The sodium and water retention causes suppression of renin release.	Water	15-20	renin	Homo sapiens	53-58
20144166-2	2009	Aquaporin 8 (AQP8) is a water channel regulating osmotic water travel across membranes.	Water	24-29	aquaporin 8	Homo sapiens	0-11
19534843-5	2009	Consumption of bottled water was inversely associated with illness (mOR 0.3, 95% CI 0.1-0.8).	Water	23-28	opioid receptor, mu 1	Mus musculus	68-71
19455640-8	2009	Free Met protected the Met residues in PTH from oxidation by H(2)O(2) and H(2)O(2) + Fe(II).	Water	61-66	parathyroid hormone	Homo sapiens	39-42
19918082-4	2009	Although commonly known as a Cl(-) channel, CFTR also conducts thiocyanate (SCN(-)) ions, important because, in several ways, they can limit potentially harmful accumulations of hydrogen peroxide (H(2)O(2)) and hypochlorite (OCl(-)).	Water	197-202	CF transmembrane conductance regulator	Homo sapiens	44-48
19455640-8	2009	Free Met protected the Met residues in PTH from oxidation by H(2)O(2) and H(2)O(2) + Fe(II).	Water	74-79	parathyroid hormone	Homo sapiens	39-42
19918082-5	2009	First, lactoperoxidase (LPO) in the airways catalyzes oxidation of SCN(-) to tissue-innocuous hypothiocyanite (OSCN(-)), while consuming H(2)O(2).	Water	137-142	lactoperoxidase	Homo sapiens	24-27
20144166-2	2009	Aquaporin 8 (AQP8) is a water channel regulating osmotic water travel across membranes.	Water	24-29	aquaporin 8	Homo sapiens	13-17
20144166-9	2009	CONCLUSION: The expression and distribution of AQP8 in AEC are diversely regulated by osmotic loads suggesting a role for AQP8 in intramembranous water transport and the balance of amniotic fluid.	Water	146-151	aquaporin 8	Homo sapiens	47-51
20144166-9	2009	CONCLUSION: The expression and distribution of AQP8 in AEC are diversely regulated by osmotic loads suggesting a role for AQP8 in intramembranous water transport and the balance of amniotic fluid.	Water	146-151	aquaporin 8	Homo sapiens	122-126
20065504-8	2009	In experimental preascitic cirrhosis NaCl retention in the ascending limb of Henle"s loop increases medullary interstitial tonicity leading to vasopressin-independent water back-diffusion in thin descending limb of Henle"s loop and collecting duct.	Water	167-172	arginine vasopressin	Rattus norvegicus	143-154
19395026-0	2009	OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus.	Water	0-4	MAF bZIP transcription factor B	Homo sapiens	118-122
19319665-4	2009	It was originally believed that the water transport capability of the collecting duct was solely under the influence of the circulating hormone, arginine vasopressin (AVP).	Water	36-41	arginine vasopressin	Homo sapiens	154-165
19924250-5	2009	PRINCIPAL FINDINGS: We report here the first observation of the coexistence in the active site, of a water molecule WAT1, along with the carboxyl terminal product (Q product) peptide.	Water	101-106	MTOR associated protein, LST8 homolog	Homo sapiens	116-120
19660505-4	2009	Here we show that salusin-beta peptide adheres to polypropylene and polystyrene, so that the aliquoted peptide dissolved in distilled water may rapidly disappear from the solution.	Water	134-139	torsin family 2 member A	Homo sapiens	18-30
19924250-9	2009	We propose WAT1 to be the position from where catalytic water attacks the scissile peptide bond.	Water	56-61	MTOR associated protein, LST8 homolog	Homo sapiens	11-15
19596064-9	2009	The decreased IP(3) receptor content observed in cells was also found in aortic rings, which exhibited a decreased ANGII-dependent contraction after treatment with H(2)O(2).	Water	164-169	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	14-28
19596064-7	2009	Moreover, we demonstrate that the decrease in IP(3)R by H(2)O(2) is accompanied by a reduction in calcium efflux induced by IP(3) in VSMC.	Water	56-61	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	46-52
19230646-2	2009	In this paper, we tried to fabricate a surface imprinted hydrogel over silica microspheres for selective recognition of bovine serum albumin by covalent immobilization of a water-soluble UV sensitive initiator onto the surface of silica beads.	Water	173-178	albumin	Homo sapiens	127-140
19632777-0	2009	Removal of Co(II) and Ni(II) ions from contaminated water using silica gel functionalized with EDTA and/or DTPA as chelating agents.	Water	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
19589641-0	2009	Adsorption of As(V) from water using Mg-Fe-based hydrotalcite (FeHT).	Water	25-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-19
19632777-1	2009	In this study, the removal of Co(II) and Ni(II) ions from contaminated water was investigated using silica gel materials functionalized with both ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA).	Water	71-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
19761754-7	2009	Previously, a crystallography study demonstrated that Bcl-x(L) formed homodimers through domain swapping in water, where Cys151 and Asn185 of two monomeric subunits are far apart from each other and the BH3-peptide binding pocket is intact.	Water	108-113	BCL2 like 1	Homo sapiens	54-62
19758989-1	2009	Glycolate oxidase is a flavin-dependent, peroxisomal enzyme that oxidizes alpha-hydroxy acids to the corresponding alpha-keto acids, with reduction of oxygen to H(2)O(2).	Water	161-166	hydroxyacid oxidase 2	Homo sapiens	0-17
19782879-1	2009	The objective of this study was to provide a new water-soluble chitosan derivative being functionalized with a Toll-like receptor-2 (TLR-2) agonist.	Water	49-54	toll like receptor 2	Homo sapiens	111-131
19782879-1	2009	The objective of this study was to provide a new water-soluble chitosan derivative being functionalized with a Toll-like receptor-2 (TLR-2) agonist.	Water	49-54	toll like receptor 2	Homo sapiens	133-138
19782879-2	2009	At first, we synthesized the water-soluble TLR-2 agonist omega-amido-[N(alpha)-palmitoyl-oxy-S-[2,3-bis(palmitoyl-oxy)-(2R)-propyl]-[R]-cysteinyl]-alpha-amino poly(ethylene glycol) (Pam(3)Cys-PEG-NH(2)), which was characterized by (1)H and (13)C NMR as well as mass spectroscopy.	Water	29-34	toll like receptor 2	Homo sapiens	43-48
19707746-0	2009	A novel analytical tool for quantification of estrogenicity in river water based on fluorescence labelled estrogen receptor alpha.	Water	69-74	estrogen receptor 1	Homo sapiens	106-129
19782211-7	2009	The method was validated by determining Pb(II) in synthetic sea water (ASTM D665) spiked with ICP multi-element standard solution and in certified reference water (GBW08607).	Water	64-69	submaxillary gland androgen regulated protein 3B	Homo sapiens	40-46
19619524-4	2009	Exposure of the cells to different doses of AA3E2 (1-16 microM) for 3h followed by subsequent exposure to a single dose of H(2)O(2) (mainly 150 microM) attenuated the extent of superoxide dismutase (SOD) and catalase (CAT) inhibition by H(2)O(2), in a dose dependent manner.	Water	123-128	catalase	Homo sapiens	218-221
19883592-1	2009	Two classes of channel-forming proteins in the eye lens, the water channel aquaporin-0 (AQP-0) and the connexins Cx46 and Cx50, are preferentially located in different regions of lens plasma membranes (1,2).	Water	61-66	major intrinsic protein of lens fiber	Homo sapiens	75-86
19883592-1	2009	Two classes of channel-forming proteins in the eye lens, the water channel aquaporin-0 (AQP-0) and the connexins Cx46 and Cx50, are preferentially located in different regions of lens plasma membranes (1,2).	Water	61-66	major intrinsic protein of lens fiber	Homo sapiens	88-93
19846791-6	2009	The structure supports earlier suggestions that the enzyme acts to lower the reduction potential of the Co(II)/Co(I) couple by elongating the bond between the cobalt and its upper axial water ligand, effectively making the cobalt 4-coordinate, and illuminates the role of Tyr-1139 in the stabilization of this 4-coordinate state.	Water	186-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
19464844-1	2009	Angiotensin II (Ang II) is a bioactive peptide that plays important roles in blood pressure regulation and salt-water homeostasis.	Water	112-117	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-14
19464844-1	2009	Angiotensin II (Ang II) is a bioactive peptide that plays important roles in blood pressure regulation and salt-water homeostasis.	Water	112-117	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	16-22
19761754-8	2009	Our results indicated that Bcl-x(L) dimer trapped by cross-linking in lipids is distinct from the domain swapped dimer, suggesting that Bcl-x(L) transits through a structural change from the water-soluble state to the membrane-bound state and there are multiple possibilities for structural reorganization of Bcl-x(L) protein.	Water	191-196	BCL2 like 1	Homo sapiens	27-35
19916943-3	2009	Enhanced heat stability, acid and alkali resistance, and anti-pepsin/trypsin ability of the modified SOD were observed compared with those of the natural enzyme, the apparent oil-water partition coefficient being especially increased.	Water	179-184	superoxide dismutase 1	Homo sapiens	101-104
19761754-8	2009	Our results indicated that Bcl-x(L) dimer trapped by cross-linking in lipids is distinct from the domain swapped dimer, suggesting that Bcl-x(L) transits through a structural change from the water-soluble state to the membrane-bound state and there are multiple possibilities for structural reorganization of Bcl-x(L) protein.	Water	191-196	BCL2 like 1	Homo sapiens	27-32
19761754-8	2009	Our results indicated that Bcl-x(L) dimer trapped by cross-linking in lipids is distinct from the domain swapped dimer, suggesting that Bcl-x(L) transits through a structural change from the water-soluble state to the membrane-bound state and there are multiple possibilities for structural reorganization of Bcl-x(L) protein.	Water	191-196	BCL2 like 1	Homo sapiens	27-34
20090122-5	2009	Nutritional oedema is associated with an increased secretion of anti-diuretic substance (probably antidiuretic hormone) which prevents the normal excretory response to water administration.	Water	168-173	arginine vasopressin	Homo sapiens	98-118
19805637-7	2009	Our results demonstrate that both Nox2 and Nox4 are required for the full vasopressor effects of brain Ang-II but that only Nox2 is coupled to the Ang-II-induced water intake response.	Water	162-167	angiotensinogen	Homo sapiens	147-153
18951133-7	2009	In the study of PCB distribution in drinking water sources, it was found that the concentration of PCBs in surface microlayer was higher than that in deep water.	Water	45-50	pyruvate carboxylase	Homo sapiens	16-19
20024957-1	2009	We have previously observed that a chronic drinking water exposure to monomethylarsonous acid [MMA(III)], a cellular metabolite of inorganic arsenic, increases tumor frequency in the skin of keratin VI/ornithine decarboxylase (K6/ODC) transgenic mice.	Water	52-57	keratin 6	Mus musculus	227-233
19966145-0	2009	Chronic exposure to arsenic in tap water reduces acetylcholine-induced relaxation in the aorta and increases oxidative stress in female rats.	Water	35-40	nuclear RNA export factor 1	Rattus norvegicus	31-34
19966145-1	2009	The aim of this work is to determine whether consuming tap water containing arsenic (20 microg/L) alters oxidative stress levels in female rats and changes vascular response.	Water	59-64	nuclear RNA export factor 1	Rattus norvegicus	55-58
19906108-5	2009	Starting from week 21 all the rats were fed with normal rat chow and tap water.	Water	73-78	nuclear RNA export factor 1	Rattus norvegicus	69-72
19374494-11	2009	The brain water content of the lesional hemisphere was higher in C57BL/6 mice than in iNOS knockout mice.	Water	10-15	nitric oxide synthase 2, inducible	Mus musculus	86-90
18993048-3	2009	In an olive oil loading study, a water-soluble CE (Cinnulin PF, 50 mg/kg body weight, orally) decreased serum triglyceride (TG) levels and the over production of total- and TG-rich lipoprotein-apoB48.	Water	33-38	apolipoprotein B	Rattus norvegicus	193-199
19781967-4	2009	To this end, we have performed molecular dynamics simulations in explicit water of the activated Stat3 homodimer, and also its closely related member of the STAT family, activated Stat1 homodimer.	Water	74-79	signal transducer and activator of transcription 3	Homo sapiens	97-102
19875801-9	2009	Replacing the N-spiked water with deionized water resulted in two times more NO3-N released from the undredged ditch sediment than the dredged ditch sediment.	Water	44-49	NBL1, DAN family BMP antagonist	Homo sapiens	77-80
20058787-2	2009	It has been demonstrated that water permeability of the epithelial cells in the collecting ducts of a rat kidney increases during development; in this process, the response to desmopressin, an agonist of vasopressin V2 receptors, appears at the age of 20 days.	Water	30-35	arginine vasopressin	Homo sapiens	204-215
19885790-3	2009	Vasopressin receptor antagonists are a new class of orally active drugs targeted to inhibit one or more of three distinct vasopressin receptors, namely V1a- (--&gt;vasoconstriction), V1b- (--&gt;release of ACTH) und V2-receptors (--&gt;inhibition of free water reabsorption in the kidney).	Water	255-260	arginine vasopressin	Homo sapiens	0-11
19778066-5	2009	However, as in the EGFR example, the binding affinity may diminish if the free-energy increase due to the removal of the bound water molecule is not more than compensated by the additional interactions of the water-displacing moiety.	Water	127-132	epidermal growth factor receptor	Homo sapiens	19-23
19778066-5	2009	However, as in the EGFR example, the binding affinity may diminish if the free-energy increase due to the removal of the bound water molecule is not more than compensated by the additional interactions of the water-displacing moiety.	Water	209-214	epidermal growth factor receptor	Homo sapiens	19-23
19634131-1	2009	Melittin dissolved in 42% trifluoroethanol-water at pH 2 has been shown to be alpha-helical between residues 6 and 12 and between residues 13 and 25, with the two helical regions separated by a bend at the Leu13 residue.	Water	43-48	interferon induced transmembrane protein 1	Homo sapiens	206-211
20081258-0	2009	Effect of peptide and nonpeptide antagonists of angiotensin II receptors on noradrenaline release in hypothalamus of rats with angiotensin II-induced increase of water intake.	Water	162-167	angiotensinogen	Rattus norvegicus	48-62
20081258-0	2009	Effect of peptide and nonpeptide antagonists of angiotensin II receptors on noradrenaline release in hypothalamus of rats with angiotensin II-induced increase of water intake.	Water	162-167	angiotensinogen	Rattus norvegicus	127-141
20030210-1	2009	Discovery of aquaporin water channel proteins has provided insight into the molecular mechanism of membrane water permeability.	Water	23-28	aquaporin	Drosophila melanogaster	13-22
19875801-7	2009	When flume water was spiked with NH4-N and NO3-N to simulate increases in N concentrations from drainage and runoff from adjacent fields, NO3-N in flume water increased during 48 h compared with the initial spiked concentration, while NH4-N decreased.	Water	11-16	NBL1, DAN family BMP antagonist	Homo sapiens	138-141
19875801-7	2009	When flume water was spiked with NH4-N and NO3-N to simulate increases in N concentrations from drainage and runoff from adjacent fields, NO3-N in flume water increased during 48 h compared with the initial spiked concentration, while NH4-N decreased.	Water	153-158	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
19875801-7	2009	When flume water was spiked with NH4-N and NO3-N to simulate increases in N concentrations from drainage and runoff from adjacent fields, NO3-N in flume water increased during 48 h compared with the initial spiked concentration, while NH4-N decreased.	Water	153-158	NBL1, DAN family BMP antagonist	Homo sapiens	138-141
19875801-8	2009	These simultaneous changes were attributed to nitrification, with 23% more NO3-N observed in flume water with undredged ditch sediment compared with dredged ditch sediment.	Water	99-104	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
19875801-9	2009	Replacing the N-spiked water with deionized water resulted in two times more NO3-N released from the undredged ditch sediment than the dredged ditch sediment.	Water	23-28	NBL1, DAN family BMP antagonist	Homo sapiens	77-80
21578138-1	2009	In the salt, (NH(4))(2)[Co(CH(4)O(6)P(2))(2)(H(2)O)(2)], the methyl-ene-diphospho-nate acts as a bidentate ligand and the Co(II) ion (site symmetry ) assumes an octa-hedral CoO(6) coordination geometry.	Water	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
19646960-2	2009	In the present study, it is shown that Coenzyme Q10 (CoQ10), a model water-insoluble compound, can be nanoparticulated into a water-soluble form using apolipoprotein A-I (apoA-I).	Water	69-74	apolipoprotein A1	Homo sapiens	151-169
19646960-2	2009	In the present study, it is shown that Coenzyme Q10 (CoQ10), a model water-insoluble compound, can be nanoparticulated into a water-soluble form using apolipoprotein A-I (apoA-I).	Water	126-131	apolipoprotein A1	Homo sapiens	151-169
19646960-2	2009	In the present study, it is shown that Coenzyme Q10 (CoQ10), a model water-insoluble compound, can be nanoparticulated into a water-soluble form using apolipoprotein A-I (apoA-I).	Water	126-131	apolipoprotein A1	Homo sapiens	171-177
19646960-4	2009	The resulting nanostructure of CoQ10 and apoA-I was water-soluble with a size of approximately 12 nm in diameter and was physically more robust than liposome.	Water	52-57	apolipoprotein A1	Homo sapiens	41-47
19570660-0	2009	In situ synthesis of water dispersible bovine serum albumin capped gold and silver nanoparticles and their cytocompatibility studies.	Water	21-26	albumin	Homo sapiens	46-59
19397935-6	2009	Significant decreases in water and food intake were seen in female NPY-/- as well as male and female PYY+NPY-/- mice during the photophase.	Water	25-30	peptide YY	Mus musculus	101-104
19309260-10	2009	Exogenous H(2)O(2) or transfection of a NOX1 plasmid restored AngII responses in NOX1-deficient cells.	Water	10-15	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	62-67
19811639-12	2009	Aquaporin-6 localization at the apical pole of the superficial epithelial cells and its upregulation by feeding suggest that it may be involved in movements of water and anions through the epithelium of the villi.	Water	160-165	aquaporin 6	Rattus norvegicus	0-11
19685041-6	2009	The analysis of Suwannee River water showed selective C18-MEPS enrichment of chemical signatures with average H/C and O/C elemental ratios and loss of both highly polar and highly aromatic structures from the original sample.	Water	31-36	Bardet-Biedl syndrome 9	Homo sapiens	54-57
19685041-8	2009	Relative comparison of structural footprints with the C18-concentration/desalting procedure however enabled to demonstrate that the surface water film was more concentrated in surface-active components of natural (fatty acids) and anthropogenic origin (sulfur-containing surfactants).	Water	140-145	Bardet-Biedl syndrome 9	Homo sapiens	54-57
19746957-2	2009	Specifically, we have measured the nine multicomponent diffusion coefficients, D(ij), for the lysozyme-poly(ethylene glycol)-NaCl-water system at pH 4.5 and 25 degrees C using precision Rayleigh interferometry.	Water	130-135	lysozyme	Homo sapiens	94-102
19809515-9	2009	Our results reveal that Dp71 is crucially implicated in the maintenance of potassium homeostasis, in transmembraneous water transport, and in the Muller cell-mediated regulation of retinal vascular permeability.	Water	118-123	dystrophin, muscular dystrophy	Mus musculus	24-28
19770501-4	2009	The observed double conformation of GluB13 was essential to interpreting the charge balance and could be compared with the structure of a dried crystal of T(6) human insulin at 100 K. Differences in the dynamic behaviour of the water molecules coordinating the upper and lower Zn ions were observed and interpreted.	Water	228-233	insulin	Homo sapiens	166-173
19640901-2	2009	For common calcium-containing stones, a critical mechanism that has been proposed for integrating water and calcium salt excretions is activation of the cell surface calcium-sensing receptor (CaSR) on the apical membranes of IMCD cells.	Water	98-103	calcium sensing receptor	Homo sapiens	166-190
19640901-2	2009	For common calcium-containing stones, a critical mechanism that has been proposed for integrating water and calcium salt excretions is activation of the cell surface calcium-sensing receptor (CaSR) on the apical membranes of IMCD cells.	Water	98-103	calcium sensing receptor	Homo sapiens	192-196
19640901-3	2009	High deliveries of calcium into the IMCD would be predicted to activate CaSR, leading to reduced membrane abundance of aquaporin-2, thereby limiting water conservation and protecting against stone formation.	Water	149-154	calcium sensing receptor	Homo sapiens	72-76
19679462-2	2009	In the electron crystallographic structures of the light driven ion pump, bacteriorhodopsin, and the water channel, aquaporin-0, sufficiently high resolution was obtained and both lipid and protein were visualized, modeled, and described in detail.	Water	101-106	major intrinsic protein of lens fiber	Homo sapiens	116-127
19701945-7	2009	Fusion of this motif to aquaporin-1 also resulted in missorting of that water channel, indicating that this retention motif is transferable.	Water	72-77	aquaporin 1 (Colton blood group)	Homo sapiens	24-35
19657734-13	2009	Recovery of water output during CFTR inhibition suggests that lubiprostone may improve the intestinal phenotype in CF patients.	Water	12-17	CF transmembrane conductance regulator	Homo sapiens	32-36
19585583-0	2009	p.R254Q mutation in the aquaporin-2 water channel causing dominant nephrogenic diabetes insipidus is due to a lack of arginine vasopressin-induced phosphorylation.	Water	36-41	arginine vasopressin	Homo sapiens	127-138
19585583-1	2009	Vasopressin regulates human water homeostasis by re-distributing homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells, a process in which phosphorylation of AQP2 at S256 by cAMP-dependent protein kinase A (PKA) is thought to be essential.	Water	28-33	arginine vasopressin	Homo sapiens	0-11
19585583-1	2009	Vasopressin regulates human water homeostasis by re-distributing homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells, a process in which phosphorylation of AQP2 at S256 by cAMP-dependent protein kinase A (PKA) is thought to be essential.	Water	99-104	arginine vasopressin	Homo sapiens	0-11
18930582-1	2009	BACKGROUND: Aquaporin 1 (AQP1) is a water channel expressed in many epithelial tissues and endothelium, including the proximal nephron of the kidney.	Water	36-41	aquaporin 1 (Colton blood group)	Homo sapiens	12-23
18930582-1	2009	BACKGROUND: Aquaporin 1 (AQP1) is a water channel expressed in many epithelial tissues and endothelium, including the proximal nephron of the kidney.	Water	36-41	aquaporin 1 (Colton blood group)	Homo sapiens	25-29
19637282-6	2009	In fructose-fed TLR-4 mutant mice, hepatic triglyceride accumulation was significantly reduced by approximately 40% in comparison to fructose-fed wildtype mice and plasma ALT levels were at the level of water-fed controls.	Water	203-208	toll-like receptor 4	Mus musculus	16-21
18255192-2	2009	Activation of hypothalamic neurons in the supraoptic nucleus that release anti-diuretic arginine-vasopressin in plasma provides water retention.	Water	128-133	arginine vasopressin	Rattus norvegicus	97-108
19583440-0	2009	An insight to the dynamics of conserved water molecular triad in IMPDH II (human): recognition of cofactor and substrate to catalytic Arg 322.	Water	40-45	inosine monophosphate dehydrogenase 2	Homo sapiens	65-73
19140140-5	2009	Monte Carlo simulation for Met-enkephalin (CHO-Tyr-Gly-Gly-Phe-Met-NH2) by using the SAAP force field revealed that the conformation in vacuo is mainly controlled by strong electrostatic interactions between the amino acid residues, while the SAAPs and the interamino acid Lennard-Jones potentials are predominant in water.	Water	317-322	proopiomelanocortin	Homo sapiens	27-41
19785566-0	2009	The effect of water-based exercise on glucose and insulin response in overweight women: a pilot study.	Water	14-19	insulin	Homo sapiens	50-57
19785566-1	2009	OBJECTIVE: The aim of this study was to investigate the effectiveness of a 12-week moderate intensity, water-based circuit-type training intervention on glucose and insulin responses in overweight women with normal or impaired glucose tolerance.	Water	103-108	insulin	Homo sapiens	165-172
19785566-8	2009	CONCLUSIONS: Moderate intensity, water-based circuit-type exercises appear to be an effective exercise modality to improve glucose and insulin response to a glucose challenge in overweight women with IGT.	Water	33-38	insulin	Homo sapiens	135-142
19787701-8	2009	Adenovirus-mediated high expression of AQP1 in HT20 cells increased relative plasma membrane water permeability and migration rate in both wound healing and invasive transwell migration assays.	Water	93-98	aquaporin 1 (Colton blood group)	Homo sapiens	39-43
19787701-9	2009	In contrary, RNA interference vector-mediated low expression of AQP1 in HT20 cells reduced relative plasma membrane water permeability and migration rate.	Water	116-121	aquaporin 1 (Colton blood group)	Homo sapiens	64-68
19406573-2	2009	The resin was used for selective separation, preconcentration and determination of Cu(II), Ni(II), Co(II), Cd(II), Pb(II), Mn(II) and Fe(III) ions in water samples by flame atomic absorption spectrometry.	Water	150-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
20027552-8	2009	The mean change in haptoglobin level was -1.7 +/- 59 mg/dL in the sterile water and 11 +/- 55 mg/dL in the saline group.	Water	74-79	haptoglobin	Homo sapiens	19-30
19619514-3	2009	In this study, we show that tumor necrosis factor-alpha (TNF-alpha) and TNF receptor-1 signaling decreased AQP3 protein expression and plasma membrane water permeability in DJM-1 keratinocytes.	Water	151-156	tumor necrosis factor	Homo sapiens	28-55
19694428-6	2009	An aliquot of freshly reconstituted Abeta(1-42) in sterile water (100 microM, pH 3.6) did not effectively stimulate the cells at a final Abeta concentration of 15 microM.	Water	59-64	amyloid beta precursor protein	Homo sapiens	36-41
19772357-1	2009	A direct white-light metal-organic framework (MOF), [AgL](n) x nH(2)O (1, L = 4-cyanobenzoate), obtained by the reaction of deprotonated 4-cyanobenzoic acid and AgNO(3) in water, was found to exhibit tunable yellow-to-white photoluminescence by variation of excitation light.	Water	172-177	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	53-56
19619514-3	2009	In this study, we show that tumor necrosis factor-alpha (TNF-alpha) and TNF receptor-1 signaling decreased AQP3 protein expression and plasma membrane water permeability in DJM-1 keratinocytes.	Water	151-156	tumor necrosis factor	Homo sapiens	57-66
19619514-3	2009	In this study, we show that tumor necrosis factor-alpha (TNF-alpha) and TNF receptor-1 signaling decreased AQP3 protein expression and plasma membrane water permeability in DJM-1 keratinocytes.	Water	151-156	tumor necrosis factor	Homo sapiens	57-60
19415169-8	2009	Brain water content, however, responded to hyponatraemia with an increase from 77.55 +/- 1.00% to 78.45 +/- 0.94% (p &lt; 0.01), and it was further augmented to 79.35 +/- 0.80% (p &lt; 0.0005) by icv AVP pretreatment.	Water	6-11	arginine vasopressin	Rattus norvegicus	200-203
19727498-12	2009	In contrast, GTS, TS, and TC1 required relative humidity well in excess of water saturation at -40 degrees C for ice formation.	Water	75-80	GTS	Homo sapiens	13-16
19727498-13	2009	GTS particles required water supersaturation conditions for ice activation even at -51 degrees C. At -51 to -57 degrees C, ice formation in particles with electrical mobility diameter of 200 nm occurred in up to 1 in 1000 TS and TC1 particles, and 1 in 100 TOS particles, at relative humidities below those required for homogeneous freezing in aqueous solutions.	Water	23-28	GTS	Homo sapiens	0-3
19658385-7	2009	The lattices in 1-3 reveal the presence of mononuclear Co(II) units bound exclusively to quinate (1 and 2) or quinate and water ligands (3), thus projecting the unique chemical reactivity in each investigated system and suggesting that 3 is an intermediate in the synthetic pathway leading to 1 and 2.	Water	122-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
19805328-5	2009	The data indicate that significant reductions in spatial learning deficits of aged APP/PS1 mice in a Morris Water Maze can be achieved by modulating levels of Nrf2 in the brain.	Water	108-113	nuclear factor, erythroid derived 2, like 2	Mus musculus	159-163
19577625-3	2009	In the present study, we investigated the effects of Scutellariae Radix water extract (SR) on proinflammatory mediators secreted from lipopolysaccharide (LPS)-induced RAW 264.7 macrophages.	Water	72-77	toll-like receptor 4	Mus musculus	154-157
19570884-0	2009	Atrial natriuretic peptide and nitric oxide signaling antagonizes vasopressin-mediated water permeability in inner medullary collecting duct cells.	Water	87-92	arginine vasopressin	Homo sapiens	66-77
19481052-2	2009	In this article, we report the accurate and reliable detection of anti-HSA (human serum albumin) antibodies by protein-functionalized magnetic nanospherical probes due to the reversible alteration of their microaggregation state induced by protein antibody-specific interaction, sensed as changes in the T(2) relaxation time of surrounding water molecules.	Water	340-345	albumin	Homo sapiens	82-95
19484468-5	2009	However, pCMBS, which inhibits AQP1, the major water exchange pathway, inhibited flickering in all cells, and yet it was restored by the membrane intercalating species dibutyl phthalate (DBP).	Water	47-52	aquaporin 1 (Colton blood group)	Homo sapiens	31-35
19587140-11	2009	Acidic condition-induced V2R enhancement was suppressed by V1aR stimulation, suggesting the crucial role of V1aR in water and electrolyte homeostasis in acidosis.	Water	116-121	arginine vasopressin receptor 2	Rattus norvegicus	25-28
19796483-1	2009	A new flow-through Fourier transform infrared (FT-IR) sensor for oil in water analysis based on solid-phase spectroscopy on octadecyl (C18) silica particles has been developed.	Water	72-77	Bardet-Biedl syndrome 9	Homo sapiens	135-138
19796483-2	2009	The C18 non-polar sorbent is placed inside the sensor and is able to retain hydrocarbons from water samples.	Water	94-99	Bardet-Biedl syndrome 9	Homo sapiens	4-7
19414243-4	2009	The stability of InS in the complex in an organic/water (O/W) interface was verified via RP-HPLC.	Water	50-55	insulin	Homo sapiens	17-20
19764219-5	2009	CH3Hg+ concentrations in the hypolimnion were substantially abated when No3 was present above the sediment-water interface.	Water	107-112	NBL1, DAN family BMP antagonist	Homo sapiens	72-75
19536161-7	2009	RESULTS: Twenty minutes after drinking a H2O or CHOE beverage, %BF (1.1 and 1.2%), impedance (12 and 14 Omega) and body mass increased significantly (P&lt;0.001).	Water	41-44	forkhead box G1	Homo sapiens	64-77
18795240-2	2009	In previous communications, we have shown that Sn-2 monoglycerides can replace Sn-1,3 regiospecific lipases at the oil-water interface, causing a drastically reduced rate of lipolysis.	Water	119-124	solute carrier family 38 member 5	Homo sapiens	47-51
18795240-2	2009	In previous communications, we have shown that Sn-2 monoglycerides can replace Sn-1,3 regiospecific lipases at the oil-water interface, causing a drastically reduced rate of lipolysis.	Water	119-124	solute carrier family 38 member 3	Homo sapiens	79-83
18795240-3	2009	We here demonstrate that even if the lipase is expelled from the interface, it can catalyze esterification of the Sn-2 monoglyceride with fatty acids in both macroscopic oil-water systems and in microemulsions, leading to formation of di- and triglycerides.	Water	174-179	solute carrier family 38 member 5	Homo sapiens	114-118
19573978-1	2009	Thermal unfolding of ribonuclease A, lysozyme, and chymotrypsinogen A was analyzed as a multisite reaction of a protein molecule with water and solute molecules.	Water	134-139	lysozyme	Homo sapiens	37-45
19915642-0	2009	[The effect of solvated ions on the thermal denaturation of human serum albumin in water-dimethylsulfoxide solutions].	Water	83-88	albumin	Homo sapiens	66-79
19915642-1	2009	The effects of solvated ions on the thermal denaturation of human serum albumin (HAS) in water-dimethylsulfoxide (DMSO) solutions were studied by the method of electron absorption spectroscopy.	Water	89-94	albumin	Homo sapiens	66-79
19578099-5	2009	When provided with free access to water, APJ(-/-) mice drank significantly less than wild-types, while their urine volume and osmolality did not differ.	Water	34-39	apelin receptor	Mus musculus	41-44
19189405-4	2009	Daily water consumption was related to daily vomiting frequency in AN-B/P but not to daily exercise frequency in either participants with AN-R or AN-B/P.	Water	6-11	natriuretic peptide A	Homo sapiens	67-73
19578099-9	2009	These findings demonstrate a physiological role for APJ in mechanisms of water intake and fluid retention and suggest an anti-diuretic effect of apelin in vivo.	Water	73-78	apelin receptor	Mus musculus	52-55
19726813-4	2009	METHODS: To simulate a pediatric patient, an 8.7 liter water-filled tub was placed on an X-ray table and exposed to 10-second cine acquisition runs.	Water	55-60	TUB bipartite transcription factor	Homo sapiens	68-71
19570565-8	2009	In contrast, water-soluble extracts of Auckland PM were more cytotoxic and resulted in greater TNF-alpha release than those from Christchurch PM, although they had a lower metal content.	Water	13-18	tumor necrosis factor	Homo sapiens	95-104
19318428-2	2009	In the kidney, vasopressin (Vp) is a critical regulator of water homeostasis by controlling the insertion of aquaporin 2 (AQP2) onto the apical membrane of the collecting duct principal cells in the short term and regulating the gene expression of AQP2 in the long term.	Water	59-64	arginine vasopressin	Homo sapiens	15-26
19494799-4	2009	Principal-cell ETB receptors also cause inhibition of water transport through protein kinase C-mediated inhibition of AVP-dependent cAMP accumulation.	Water	54-59	endothelin receptor type B	Homo sapiens	15-18
19706523-0	2009	Structural waters define a functional channel mediating activation of the GPCR, rhodopsin.	Water	11-17	rhodopsin	Homo sapiens	80-89
19895107-4	2009	Lipophilic dialkylcarbocyanines DiD and DiR are loaded very efficiently in 30-35-nm-diam lipid droplets stabilized in water by surfactants.	Water	118-123	arginine vasopressin receptor 2	Homo sapiens	40-43
19847101-5	2009	This kind of interaction could be an additional mechanism for regulating membrane water permeability by acting on the activity and/or trafficking of PIP hetero-oligomers.	Water	82-87	pip	Zea mays	149-152
19947313-0	2009	[Insulin glargine and cancer: a storm in a glass of water?].	Water	52-57	insulin	Homo sapiens	1-8
20030090-3	2009	RESULT: Alcohol and water extracted B. chinense composition all could induce the increases of the activity of ALT and AST in serum, liver weight and the ratio of liver to body, and the content of MDA and induce the decreses of the content of total -SH in serum, the content of GSH, and the activity of SOD and GSH-Px in serum and liver tissue.	Water	20-25	glutathione peroxidase 1	Rattus norvegicus	310-316
19601623-9	2009	Detection limits for all individual PCB congeners ranged from &lt;1 to 3 pg/mL using 1.5 mL water samples.	Water	92-97	pyruvate carboxylase	Homo sapiens	36-39
26613157-1	2009	We report here a study of the conformational energy landscape of the pentapeptide Met-enkephalin in the presence of explicit solvent (water) molecules.	Water	134-139	proopiomelanocortin	Homo sapiens	82-96
19559588-1	2009	An attractive biocomposite based on polycrystalline bismuth oxide (BiO(x)) film and polyphenol oxidase (PPO) was proposed for the construction of a mediator-free amperometric biosensor for phenolic compounds in environmental water samples.	Water	225-230	protoporphyrinogen oxidase	Homo sapiens	84-102
19559588-1	2009	An attractive biocomposite based on polycrystalline bismuth oxide (BiO(x)) film and polyphenol oxidase (PPO) was proposed for the construction of a mediator-free amperometric biosensor for phenolic compounds in environmental water samples.	Water	225-230	protoporphyrinogen oxidase	Homo sapiens	104-107
19386536-6	2009	The formation of molecular clusters by means of the 1,2,3,9-tetrahydro-4H-carbazol-4-one wrapped up with water molecules leads to the weakness of the interaction between the polar solvents and the 1,2,3,9-tetrahydro-4H-carbazol-4-one, hence, the accuracy of pK(b) has been enhanced.	Water	105-110	AKT serine/threonine kinase 1	Homo sapiens	258-263
19588945-6	2009	An X-ray crystallographic analysis of 4 and computational analyses of 4 and 5 bound to the GluR5 agonist binding domain (ABD) are presented, including a watermap analysis, which suggests that water molecules in the agonist binding site are important selectivity determinants.	Water	153-158	glutamate ionotropic receptor kainate type subunit 1	Homo sapiens	91-96
26613157-6	2009	The results also indicate that the pentapeptide Met-enkephalin prefers extended structures in an aqueous environment, as against tightly folded structures in the absence of water.	Water	173-178	proopiomelanocortin	Homo sapiens	48-62
19588949-7	2009	Changing the pair potentials of water-water interactions from SPC/E to TIP4P-2005 has not had any effect in this respect.	Water	32-37	proline rich protein gene cluster	Homo sapiens	62-65
19515809-8	2009	On the other hand, the latter combination significantly enhanced the transport activity of the related AQP3 water channel while the presence of syntaxin-3 did not.	Water	108-113	aquaporin 3	Canis lupus familiaris	103-107
19652294-2	2009	The Co(II) ions have local 4/m symmetry, with the equatorial water molecules in the mirror plane, while the V and apical O atom of the vanadyl group are located on the fourfold rotation axis and the P atoms reside on 4 sites.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
19353641-1	2009	2SS[6-127,64-80] variant of lysozyme which has two disulfide bridges, Cys6-Cys127 and Cys64-Cys80, and lacks the other two disulfide bridges, Cys30-Cys115 and Cys76-Cys94, was quite unstructured in water, but a part of the polypeptide chain was gradually frozen into a native-like conformation with increasing glycerol concentration.	Water	198-203	lysozyme	Homo sapiens	28-36
22444837-8	2009	Total milk yield, peak yield and maximum secretion potential were all highly correlated with milk, lactose and water secretion rates but less so with fat and protein secretion rates.	Water	111-116	Weaning weight-maternal milk	Bos taurus	6-10
19216812-3	2009	Hypertriacylglycerolaemia was induced in male Sprague-Dawley rats (ten rats per group) by supplementing tap water with 10 % fructose.	Water	108-113	nuclear RNA export factor 1	Rattus norvegicus	104-107
19554441-7	2009	Drugs that antagonize the vasopressin V(2) receptor, which is primarily responsible for water resorption in the kidney, are now available and have been studied in patients with HF.	Water	88-93	arginine vasopressin receptor 2	Homo sapiens	26-51
19574955-4	2009	We report that three point mutations turned the water-specific AQP1 into a proton/alkali cation channel with reduced water permeability and the permeability sequence: H(+) &gt;&gt;K(+) &gt;Rb(+) &gt;Na(+) &gt;Cs(+) &gt;Li(+).	Water	48-53	aquaporin 1 (Colton blood group)	Homo sapiens	63-67
19574955-4	2009	We report that three point mutations turned the water-specific AQP1 into a proton/alkali cation channel with reduced water permeability and the permeability sequence: H(+) &gt;&gt;K(+) &gt;Rb(+) &gt;Na(+) &gt;Cs(+) &gt;Li(+).	Water	117-122	aquaporin 1 (Colton blood group)	Homo sapiens	63-67
19594375-14	2009	CONCLUSION: In this in vitro study, a single 25 mL instillation of t-PA solution 2 mg/mL is significantly better than sterile water alone for clot evacuation.	Water	126-131	plasminogen activator, tissue type	Homo sapiens	67-71
19711671-1	2009	Mark Bosley, systems specialist at designer, developer and manufacturer of water purification systems for the healthcare and research sectors Purite, examines the growing regulatory framework governing the purity and quality of water supplied to decontamination centres, and discusses some of the latest technologies used to ensure the required standards are met.	Water	75-80	microtubule affinity regulating kinase 1	Homo sapiens	0-4
19735174-2	2009	Water extracts of both herbal materials were tested in vitro with a battery of assay models: lipopolysaccharide-induced thromboxane B(2) for cyclooxygenase-1 (COX-1), prostaglandin E(2) for cyclooxygenase-2 (COX-2), the translocation of nuclear factor-kappaB (NF-kappaB), and tumor necrosis factor alpha (TNFalpha) and nitric oxide (NO) production in RAW 264.7 cells.	Water	0-5	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	237-258
18821261-1	2009	Catalase in albumin microspheres were formulated for intravenous administration to antagonize the effects of over-production of reactive oxygenated species (ROS) such as hydrogen peroxide (H(2)O(2)) in septic shock.	Water	189-194	catalase	Homo sapiens	0-8
19403319-3	2009	In the present study, we determined the structure of uPA and uPAR complex in water and investigated the specific interactions between uPA and uPAR by ab initio molecular orbital (MO) calculations based on fragment MO method.	Water	77-82	plasminogen activator, urokinase	Homo sapiens	53-56
19403319-3	2009	In the present study, we determined the structure of uPA and uPAR complex in water and investigated the specific interactions between uPA and uPAR by ab initio molecular orbital (MO) calculations based on fragment MO method.	Water	77-82	plasminogen activator, urokinase	Homo sapiens	61-64
19403319-5	2009	The influence of crystal water molecules existing between uPA and uPAR was also investigated to be significant on the specific interactions between uPA and uPAR.	Water	25-30	plasminogen activator, urokinase	Homo sapiens	58-61
19403319-5	2009	The influence of crystal water molecules existing between uPA and uPAR was also investigated to be significant on the specific interactions between uPA and uPAR.	Water	25-30	plasminogen activator, urokinase	Homo sapiens	66-69
19735174-2	2009	Water extracts of both herbal materials were tested in vitro with a battery of assay models: lipopolysaccharide-induced thromboxane B(2) for cyclooxygenase-1 (COX-1), prostaglandin E(2) for cyclooxygenase-2 (COX-2), the translocation of nuclear factor-kappaB (NF-kappaB), and tumor necrosis factor alpha (TNFalpha) and nitric oxide (NO) production in RAW 264.7 cells.	Water	0-5	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	260-269
19735174-2	2009	Water extracts of both herbal materials were tested in vitro with a battery of assay models: lipopolysaccharide-induced thromboxane B(2) for cyclooxygenase-1 (COX-1), prostaglandin E(2) for cyclooxygenase-2 (COX-2), the translocation of nuclear factor-kappaB (NF-kappaB), and tumor necrosis factor alpha (TNFalpha) and nitric oxide (NO) production in RAW 264.7 cells.	Water	0-5	tumor necrosis factor	Mus musculus	276-303
19735174-2	2009	Water extracts of both herbal materials were tested in vitro with a battery of assay models: lipopolysaccharide-induced thromboxane B(2) for cyclooxygenase-1 (COX-1), prostaglandin E(2) for cyclooxygenase-2 (COX-2), the translocation of nuclear factor-kappaB (NF-kappaB), and tumor necrosis factor alpha (TNFalpha) and nitric oxide (NO) production in RAW 264.7 cells.	Water	0-5	tumor necrosis factor	Mus musculus	305-313
19688033-0	2009	Solar water disinfection in household settings: hype or hope?	Water	6-11	FIC domain protein adenylyltransferase	Homo sapiens	48-52
19569188-5	2009	The affinities of a series of peptides for both wild-type and mutant forms of the PDZ domain of Erbin correlate very well with the computed free energy of binding of displaced waters, suggesting a direct relationship between water displacement and peptide affinity.	Water	176-181	erbb2 interacting protein	Homo sapiens	96-101
18635703-2	2009	The main objective of this in human study was to assess the sedative properties of Org 28611, a potent water-soluble CB1 agonist.	Water	103-108	cannabinoid receptor 1	Homo sapiens	117-120
19298230-1	2009	Recent studies have indicated that brain and gut activities are interrelated and exposure to several stressors, such as water-avoidance stress, stimulates the motor function of the gut through corticotropin-releasing factor (CRF)-signalling pathways in the brain.	Water	120-125	corticotropin releasing hormone	Rattus norvegicus	193-223
19555082-0	2009	Micro-Raman spectroscopic observation of water expulsion induced destruction of hydrophobic clusters in crystalline lysozyme.	Water	41-46	lysozyme	Homo sapiens	116-124
19652506-3	2009	By observing relationship between the compounds" physicochemical properties and APPI response, compounds with higher lipophilicity and less polar surface area were considered to be advantageous for APPI-MS. To provide information for applying APPI-MS to the analysis of hydrophilic drugs, approximate lower limit of calculated octanol-water partition coefficient and the higher limit of the number of oxygen and nitrogen atoms were determined to be -0.95 and 6, respectively.	Water	335-340	amyloid beta precursor protein	Homo sapiens	80-84
19652506-3	2009	By observing relationship between the compounds" physicochemical properties and APPI response, compounds with higher lipophilicity and less polar surface area were considered to be advantageous for APPI-MS. To provide information for applying APPI-MS to the analysis of hydrophilic drugs, approximate lower limit of calculated octanol-water partition coefficient and the higher limit of the number of oxygen and nitrogen atoms were determined to be -0.95 and 6, respectively.	Water	335-340	amyloid beta precursor protein	Homo sapiens	198-202
19652506-3	2009	By observing relationship between the compounds" physicochemical properties and APPI response, compounds with higher lipophilicity and less polar surface area were considered to be advantageous for APPI-MS. To provide information for applying APPI-MS to the analysis of hydrophilic drugs, approximate lower limit of calculated octanol-water partition coefficient and the higher limit of the number of oxygen and nitrogen atoms were determined to be -0.95 and 6, respectively.	Water	335-340	amyloid beta precursor protein	Homo sapiens	198-202
19167160-7	2009	All three different kinds of maghemite nanoparticles were successful in removing As(V) from water, one of them reached as high adsorption capacity as 50mg/g.	Water	92-97	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	81-86
19649279-6	2009	Similarly, contractile and calcium responses to 5-HT were decreased by superoxide dismutase and catalase which, catabolise superoxide anion and H(2)O(2), respectively.	Water	144-149	catalase	Homo sapiens	96-104
19555082-1	2009	In this paper, three kinds of solid lysozyme samples with different water contents were investigated by confocal Raman spectroscopy.	Water	68-73	lysozyme	Homo sapiens	36-44
19555082-2	2009	For the rod-like lysozyme crystal with highest water content, a sudden decrease of the intensity ratio of the doublet at 1338 and 1360 cm(-1) was observed when the ambient relative humidity (RH) was lower than 86%, indicating the destruction of hydrophobic clusters of lysozyme induced by the expulsion of the hydration water from the crystal.	Water	47-52	lysozyme	Homo sapiens	17-25
20628467-5	2009	The average diameter (d) of bFGF-loaded MSNs is 57 +- 8 nm produced by a water-in-oil microemulsion method.	Water	73-78	fibroblast growth factor 2	Homo sapiens	28-32
19555082-2	2009	For the rod-like lysozyme crystal with highest water content, a sudden decrease of the intensity ratio of the doublet at 1338 and 1360 cm(-1) was observed when the ambient relative humidity (RH) was lower than 86%, indicating the destruction of hydrophobic clusters of lysozyme induced by the expulsion of the hydration water from the crystal.	Water	47-52	lysozyme	Homo sapiens	269-277
19555082-2	2009	For the rod-like lysozyme crystal with highest water content, a sudden decrease of the intensity ratio of the doublet at 1338 and 1360 cm(-1) was observed when the ambient relative humidity (RH) was lower than 86%, indicating the destruction of hydrophobic clusters of lysozyme induced by the expulsion of the hydration water from the crystal.	Water	320-325	lysozyme	Homo sapiens	17-25
19587238-1	2009	Binding of the peptide hormone vasopressin to its type-2 receptor (V2R) in kidney triggers a cAMP-mediated translocation of Aquaporin-2 water channels to the apical membrane, resulting in water reabsorption and thereby preventing dehydration.	Water	136-141	arginine vasopressin	Homo sapiens	31-42
19587238-1	2009	Binding of the peptide hormone vasopressin to its type-2 receptor (V2R) in kidney triggers a cAMP-mediated translocation of Aquaporin-2 water channels to the apical membrane, resulting in water reabsorption and thereby preventing dehydration.	Water	136-141	arginine vasopressin receptor 2	Homo sapiens	67-70
19587238-1	2009	Binding of the peptide hormone vasopressin to its type-2 receptor (V2R) in kidney triggers a cAMP-mediated translocation of Aquaporin-2 water channels to the apical membrane, resulting in water reabsorption and thereby preventing dehydration.	Water	188-193	arginine vasopressin	Homo sapiens	31-42
19587238-1	2009	Binding of the peptide hormone vasopressin to its type-2 receptor (V2R) in kidney triggers a cAMP-mediated translocation of Aquaporin-2 water channels to the apical membrane, resulting in water reabsorption and thereby preventing dehydration.	Water	188-193	arginine vasopressin receptor 2	Homo sapiens	67-70
19607658-2	2009	There are 13 known mammalian aquaporins (AQP0 to AQP12), some of which have been shown to have unexpected cellular roles beyond transmembrane water transport.	Water	142-147	major intrinsic protein of lens fiber	Homo sapiens	41-45
19545111-0	2009	Photocatalytic generation of oxygen radicals by the water-soluble bacteriochlorophyll derivative WST11, noncovalently bound to serum albumin.	Water	52-57	albumin	Homo sapiens	127-140
19328034-0	2009	Fluorimetric study of water-ethanol interaction and its effect on the micellisation of sodium dodecyl sulphate in the presence of bovine serum albumin.	Water	22-27	albumin	Homo sapiens	137-150
19268556-10	2009	It is possible that anuran AQP3might protect the epidermis against cutaneous water loss by supplying water and glycerol.	Water	77-82	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	27-31
19584911-0	2009	AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin.	Water	19-24	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
19244407-2	2009	The antidiuretic hormone arginine vasopressin (AVP) increases collecting duct water permeability by enhancing aquaporin-2 (AQP2) water channel insertion in the apical membrane of principal cells, allowing water to passively flow along the osmotic gradient from the tubule lumen to the interstitium.	Water	78-83	arginine vasopressin	Homo sapiens	34-45
19244407-2	2009	The antidiuretic hormone arginine vasopressin (AVP) increases collecting duct water permeability by enhancing aquaporin-2 (AQP2) water channel insertion in the apical membrane of principal cells, allowing water to passively flow along the osmotic gradient from the tubule lumen to the interstitium.	Water	78-83	arginine vasopressin	Homo sapiens	47-50
19244407-2	2009	The antidiuretic hormone arginine vasopressin (AVP) increases collecting duct water permeability by enhancing aquaporin-2 (AQP2) water channel insertion in the apical membrane of principal cells, allowing water to passively flow along the osmotic gradient from the tubule lumen to the interstitium.	Water	129-134	arginine vasopressin	Homo sapiens	34-45
19244407-2	2009	The antidiuretic hormone arginine vasopressin (AVP) increases collecting duct water permeability by enhancing aquaporin-2 (AQP2) water channel insertion in the apical membrane of principal cells, allowing water to passively flow along the osmotic gradient from the tubule lumen to the interstitium.	Water	129-134	arginine vasopressin	Homo sapiens	47-50
19244407-2	2009	The antidiuretic hormone arginine vasopressin (AVP) increases collecting duct water permeability by enhancing aquaporin-2 (AQP2) water channel insertion in the apical membrane of principal cells, allowing water to passively flow along the osmotic gradient from the tubule lumen to the interstitium.	Water	129-134	arginine vasopressin	Homo sapiens	34-45
19244407-2	2009	The antidiuretic hormone arginine vasopressin (AVP) increases collecting duct water permeability by enhancing aquaporin-2 (AQP2) water channel insertion in the apical membrane of principal cells, allowing water to passively flow along the osmotic gradient from the tubule lumen to the interstitium.	Water	129-134	arginine vasopressin	Homo sapiens	47-50
18836965-2	2009	These results suggest that VP increases the influx of water from the perlymph to the basal cells via aquaporin (AQP) 2 and causes the formation of endolymphatic hydrops.	Water	54-59	arginine vasopressin	Rattus norvegicus	27-29
19362168-8	2009	These data demonstrate that rats pretreated with 5% taurine in their drinking water prior to bleomycin instillation are protected from fibrosis, inflammatory infiltrates, as well as nitric oxide and TNF-alpha production, which are hallmarks of bleomycin lung injury.	Water	78-83	tumor necrosis factor	Rattus norvegicus	199-208
19513559-0	2009	Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt.	Water	60-65	caspase 3	Homo sapiens	132-141
19513559-0	2009	Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt.	Water	60-65	AKT serine/threonine kinase 1	Homo sapiens	168-171
19423692-7	2009	In co-expression experiments, P2R activation decreased membrane AQP2 and AQP2-mediated water permeability in Xenopus oocytes expressing P2X(2), P2Y(2,) or P2Y(4) receptors, but not in oocytes expressing other P2R subtypes.	Water	87-92	aquaporin 2 S homeolog	Xenopus laevis	73-77
19423692-8	2009	In summary, these data suggest that AQP2-mediated water transport is downregulated not only by basolateral nucleotides, mediated by P2Y(2) receptors, but also by luminal nucleotides, mediated by P2X(2) and/or P2Y(4) receptors.	Water	50-55	purinergic receptor P2Y, G-protein coupled 2	Mus musculus	132-138
19268556-10	2009	It is possible that anuran AQP3might protect the epidermis against cutaneous water loss by supplying water and glycerol.	Water	101-106	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	27-31
19548636-3	2009	We used the Orru three component reaction (O-3CR) along with a rapid and efficient, recently discovered amidation reaction to dramatically improve the water solubility of our recently discovered low molecular weight p53/mdm2 antagonists.	Water	151-156	tumor protein p53	Homo sapiens	216-219
19590712-4	2009	In this study we investigated the effects of LANSO on the production of TNF-alpha and IL-1beta induced by lipopolysaccharide (LPS) and Helicobacter pylori water-soluble extract (HpWE) in the human monocytic cell line (THP-1).	Water	155-160	tumor necrosis factor	Homo sapiens	72-81
19590712-4	2009	In this study we investigated the effects of LANSO on the production of TNF-alpha and IL-1beta induced by lipopolysaccharide (LPS) and Helicobacter pylori water-soluble extract (HpWE) in the human monocytic cell line (THP-1).	Water	155-160	interleukin 1 beta	Homo sapiens	86-94
19566644-4	2009	Pretreatments with different protein kinase inhibitors also reduced the water stress-induced H2O2 production and the water stress-enhanced activities of antioxidant enzymes such as superoxide dismutase, catalase, ascorbate peroxidase and glutathione reductase.	Water	117-122	peroxidase 1	Zea mays	223-233
19481256-8	2009	Water uptake experiments were performed using explants from human normal term and preeclamptic placentas treated with CFTR inhibitors.	Water	0-5	CF transmembrane conductance regulator	Homo sapiens	118-122
19562113-3	2009	In contrast, single molecules of cyt c are encapsulated in silica nanoparticles by sol-gel reactions at the oil-water interface of microemulsion water droplets.	Water	112-117	cytochrome c, somatic	Homo sapiens	33-38
19562113-3	2009	In contrast, single molecules of cyt c are encapsulated in silica nanoparticles by sol-gel reactions at the oil-water interface of microemulsion water droplets.	Water	145-150	cytochrome c, somatic	Homo sapiens	33-38
19461023-5	2009	The long-term outcome, as measured by survival time, change in body weight, and mapping of apparent diffusion coefficient (ADC) for ion/water homeostasis, was significantly better in the SOD1-Tg rats.	Water	136-141	superoxide dismutase 1	Rattus norvegicus	187-191
19481256-10	2009	Functional experiments demonstrated that water uptake diminished in normal term explants incubated with CFTR inhibitors.	Water	41-46	CF transmembrane conductance regulator	Homo sapiens	104-108
19406128-2	2009	Based on the electron crystallographic structure of AQP1, the hydrogen-bond isolation mechanism was proposed to explain why AQPs are impermeable to protons despite their very fast water conduction.	Water	180-185	aquaporin 1 (Colton blood group)	Homo sapiens	52-56
19456103-4	2009	Fluorescence measurements suggested that DMPC possesses a lower entropy in nanodiscs than in vesicles, because apoA-I molecules, which surround the bilayer, force closer lipid packing, but allow water penetration to the acyl chain ends.	Water	195-200	apolipoprotein A1	Homo sapiens	111-117
19467350-3	2009	Here we investigated cell adhesion, and the ion and water permeability of Bib.	Water	52-57	big brain	Drosophila melanogaster	74-77
19467350-7	2009	When expressed in COS7 cells, Bib exhibited limited water permeability.	Water	52-57	big brain	Drosophila melanogaster	30-33
19348936-6	2009	In the presence of H(2)O(2), SHP-2 formed a complex with STAT-3 and reduced the steady-state STAT-3 phosphorylation level.	Water	19-24	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	29-34
19385641-4	2009	According to atomic force microscopy images and dynamic light scattering measurements, the partial DMSO-induced dissection of insulin fibrils favors formation of smaller soluble oligomers, which retain a limited capacity to induce daughter generation of fibrils through seeding to the native insulin, as well as the ability to reassemble into fibrils upon removal of DMSO through dialysis against water.	Water	397-402	insulin	Homo sapiens	126-133
19341793-10	2009	These results, together with the fact that catalase is an H(2)O(2) scavenger, suggest that endogenously produced H(2)O(2) mediates MAEC proliferation by fostering the transition from G(0)/G(1) to S phase.	Water	58-63	catalase	Mus musculus	43-51
19081184-0	2009	Crystal and morphological phase transformation of Pb(II) to Pb(IV) in chlorinated water.	Water	82-87	submaxillary gland androgen regulated protein 3B	Homo sapiens	50-56
19081184-1	2009	Herein, we show an important transformation of Pb(II) to Pb(IV) in chlorinated water under laboratory conditions.	Water	79-84	submaxillary gland androgen regulated protein 3B	Homo sapiens	47-53
19097694-1	2009	The effects water mist has on the overpressures produced by the detonation of 50 lb equivalent of high explosives (HE) TNT and Destex in a chamber is reported.	Water	12-17	chromosome 16 open reading frame 82	Homo sapiens	119-122
19446755-3	2009	The pegylated lysozyme/CyD polypseudorotaxanes were less soluble in water and the release rate of the pegylated protein decreased in the order of the pegylated lysozyme&gt;the gamma-CyD polypseudorotaxane&gt;the alpha-CyD polypseudorotaxane.	Water	68-73	lysozyme	Homo sapiens	14-22
19458858-8	2009	With an applied voltage of 2.5 V, the maximum pumping rate for DI water and whole blood were 121 nl min(-1) and 88 nl min(-1), respectively, with a channel cross section of 100 x 50 microm.	Water	66-71	CD59 molecule (CD59 blood group)	Homo sapiens	100-106
19353602-0	2009	Adsorption of insulin peptide on charged single-walled carbon nanotubes: significant role of ordered water molecules.	Water	101-106	insulin	Homo sapiens	14-21
19458858-8	2009	With an applied voltage of 2.5 V, the maximum pumping rate for DI water and whole blood were 121 nl min(-1) and 88 nl min(-1), respectively, with a channel cross section of 100 x 50 microm.	Water	66-71	CD59 molecule (CD59 blood group)	Homo sapiens	118-124
19201188-0	2009	Study on solvent extraction of propionic acid from simulated discharged water in vitamin B12 production by anaerobic fermentation.	Water	72-77	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	89-92
19329139-6	2009	The surface water with the highest total organic carbon concentration exhibited the most dramatic nitroaromatic loss from solution with tetryl, 1,3,5-TNB and TNT concentrations decreasing to below detection within 10d.	Water	12-17	chromosome 16 open reading frame 82	Homo sapiens	158-161
19247368-3	2009	After exposure to hydrogen peroxide (H(2)O(2)) or a strong ROS inducer parthenolide, loss of mitochondrial membrane potential (MMP) and subsequent cell death occurred more extensively in XBP1-deficient cells than wild-type mouse embryonic fibroblast cells, whereas two other anticancer agents induced death similarly in both cells.	Water	37-42	X-box binding protein 1	Mus musculus	187-191
18806765-5	2009	RESULTS: LECs exposed to H(2)O(2) (5 x 10(-6) M) showed a fourfold increase in catalase activity (407.03+/-89.11 U/microg protein) after 6 h when compared to cultured unexposed LECs (97.124+/-9.4 U/microg protein).	Water	25-30	catalase	Homo sapiens	79-87
19551730-0	2009	Immunological adjuvant effect of a water-soluble polysaccharide, CPP, from the roots of Codonopsis pilosula on the immune responses to ovalbumin in mice.	Water	35-40	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	135-144
19378941-4	2009	Compound [Cu(2)(HL)(N(3))(2)(H(2)O)].0.5CH(3)OH (4) formed from the reaction of Cu(CH(3)CO(2))(2) with H(3)L under reflux, which did not afford crystals suitable for X-ray studies.	Water	29-35	H3 clustered histone 2	Homo sapiens	103-108
18766438-3	2009	Arginine vasopressin (AVP) via the V(1A) receptor vasoconstricts and via the V(2) receptor promotes water reabsorption in the renal collecting duct by inserting aquaporin-2 water channels into the luminal membrane.	Water	100-105	arginine vasopressin	Homo sapiens	0-20
18766438-3	2009	Arginine vasopressin (AVP) via the V(1A) receptor vasoconstricts and via the V(2) receptor promotes water reabsorption in the renal collecting duct by inserting aquaporin-2 water channels into the luminal membrane.	Water	173-178	arginine vasopressin	Homo sapiens	0-20
18777208-3	2009	The binding of AVP to V(2) receptors in the renal collecting duct promotes water retention, a process that can lead to dilutional hyponatremia as well as increased ventricular preload.	Water	75-80	arginine vasopressin	Homo sapiens	15-18
19424603-0	2009	MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells.	Water	61-66	mitogen-activated protein kinase kinase 7	Homo sapiens	0-3
20442823-6	2009	Catalase (500 U/ml) partially antagonized the Ang-II-induced contraction, as well as antagonized the potentiation induced by H(2)O(2).	Water	125-130	catalase	Rattus norvegicus	0-8
19424603-0	2009	MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells.	Water	61-66	mitogen-activated protein kinase 1	Homo sapiens	4-7
19424603-5	2009	UV and H2O2 as well as AQP1-specific siRNA knockdown impaired water permeability of ARPE-19 cells.	Water	62-67	aquaporin 1 (Colton blood group)	Homo sapiens	23-27
19422244-4	2009	We performed a 40 ns molecular dynamics simulation of the mGluR2/5HT(2A) heterocomplex constructed around a TM4/TM5 interface and embedded in an explicit phospholipidic bilayer surrounded by water molecules.	Water	191-196	5-hydroxytryptamine receptor 2A	Homo sapiens	65-71
19472194-4	2009	Plasma membrane osmotic water permeability analysis, measured by YFP-based fluorescence quenching method and Xenopus oocyte expression assays, demonstrated that NPA1 or NPA2 deletion significantly reduced human AQP1 water permeability nearly 50% compared to wild-type AQP1, while NPA1,2 double deletion had little effect on human AQP1 water permeability.	Water	24-29	URB1 ribosome biogenesis homolog	Homo sapiens	161-165
19472194-4	2009	Plasma membrane osmotic water permeability analysis, measured by YFP-based fluorescence quenching method and Xenopus oocyte expression assays, demonstrated that NPA1 or NPA2 deletion significantly reduced human AQP1 water permeability nearly 50% compared to wild-type AQP1, while NPA1,2 double deletion had little effect on human AQP1 water permeability.	Water	216-221	URB1 ribosome biogenesis homolog	Homo sapiens	161-165
19472194-4	2009	Plasma membrane osmotic water permeability analysis, measured by YFP-based fluorescence quenching method and Xenopus oocyte expression assays, demonstrated that NPA1 or NPA2 deletion significantly reduced human AQP1 water permeability nearly 50% compared to wild-type AQP1, while NPA1,2 double deletion had little effect on human AQP1 water permeability.	Water	216-221	aquaporin 1 (Colton blood group)	Homo sapiens	211-215
19472194-4	2009	Plasma membrane osmotic water permeability analysis, measured by YFP-based fluorescence quenching method and Xenopus oocyte expression assays, demonstrated that NPA1 or NPA2 deletion significantly reduced human AQP1 water permeability nearly 50% compared to wild-type AQP1, while NPA1,2 double deletion had little effect on human AQP1 water permeability.	Water	216-221	URB1 ribosome biogenesis homolog	Homo sapiens	161-165
19472194-4	2009	Plasma membrane osmotic water permeability analysis, measured by YFP-based fluorescence quenching method and Xenopus oocyte expression assays, demonstrated that NPA1 or NPA2 deletion significantly reduced human AQP1 water permeability nearly 50% compared to wild-type AQP1, while NPA1,2 double deletion had little effect on human AQP1 water permeability.	Water	216-221	aquaporin 1 (Colton blood group)	Homo sapiens	211-215
19550045-2	2009	We investigated A beta (25-35) aggregation in H2O at pH 3.0 and at pH 7.4 by means of in-solution analyses.	Water	46-49	amyloid beta precursor protein	Homo sapiens	16-22
19550045-3	2009	Adopting UV spectroscopy, Congo red spectrophotometry and thioflavin T fluorimetry, we were able to quantify, in water, the very fast assembling time necessary for A beta (25-35) to form stable insoluble aggregates and their ability to seed or not seed fibril growth.	Water	113-118	amyloid beta precursor protein	Homo sapiens	164-170
19409844-9	2009	Serum growth hormone concentrations, adjusted for covariates, were positively associated with per cent breast water (p=0.001) in a subgroup of young women (n=280) who had not used oral contraceptives within 6 months.	Water	110-115	growth hormone 1	Homo sapiens	6-20
19409844-10	2009	INTERPRETATION: Per cent breast water was greatest during the ages when women are most susceptible to breast carcinogens, and was associated with weight, height, and mother"s breast-tissue characteristics, and with serum concentrations of growth hormone: a breast mitogen that also mediates postnatal somatic growth.	Water	32-37	growth hormone 1	Homo sapiens	239-253
19285782-6	2009	In addition, the water bath temperature was varied from 30 to 36 degrees C. The Hsp72 protein expression was determined 4 and 24 h after treatment.	Water	17-22	heat shock protein family A (Hsp70) member 1A	Homo sapiens	80-85
18939936-3	2009	In vitro SPI biofilm degradation was evaluated as a function of water absorption leading to weight and size modifications.	Water	64-69	chromogranin A	Homo sapiens	9-12
19285782-8	2009	After increasing the temperature of the water bath, the amount of Hsp72 in the treated cells was also increased, whereas no induction was observed at 30 degrees C. For all treatment conditions, ultrasound of 1 MHz was unable to significantly induce Hsp72.	Water	40-45	heat shock protein family A (Hsp70) member 1A	Homo sapiens	66-71
19345674-6	2009	Our results suggest that MPO produces atheronals at least partly through an ozone-free mechanism, via the reaction of cholesterol with singlet oxygen generated from HOCl and H(2)O(2).	Water	174-179	myeloperoxidase	Homo sapiens	25-28
19842562-7	2009	The correlation among Ngb contents in serum, CSF, frontal cortex and water content of frontal cortex was analyzed with multiple comparison.	Water	69-74	neuroglobin	Rattus norvegicus	22-25
19842562-12	2009	Ngb contents in serum, CSF, frontal cortex, and water content of frontal cortex were positively correlated with multiple comparison ( y = 0.631-0.719, P &lt; 0.01).	Water	48-53	neuroglobin	Rattus norvegicus	0-3
19375083-2	2009	The values of log K(doc) determined with equilibrium SPME were linearly correlated with the logarithm of the octanol-water partition coefficients (K(ow)) for PCB congeners at logK(ow)&lt; approximately 7.2, but the trends were disrupted for logK(ow) from approximately 7.2 to 8.18.	Water	117-122	pyruvate carboxylase	Homo sapiens	158-161
19193633-1	2009	Vasopressin controls renal water excretion largely through actions to regulate the water channel aquaporin-2 in collecting duct principal cells.	Water	27-32	arginine vasopressin	Homo sapiens	0-11
19422184-0	2009	Theoretical investigation of the interaction between fluorinated dimethyl ethers (nF = 1-5) and water: role of the acidity and basicity on the competition between OH...O and CH...O hydrogen bonds.	Water	96-101	neurofibromin 1	Homo sapiens	82-90
19422184-1	2009	Theoretical calculations have been carried out using ab initio MP2 and B3LYP density functional methods to investigate the interaction between fluorinated dimethyl ethers (nF = 1-5) and water.	Water	186-191	neurofibromin 1	Homo sapiens	172-180
19345674-3	2009	In this study, we found that atheronals were formed by the reaction of cholesterol with human myeloperoxidase (MPO) in the presence of its substrates H(2)O(2) and Cl(-).	Water	150-155	myeloperoxidase	Homo sapiens	94-109
19345674-3	2009	In this study, we found that atheronals were formed by the reaction of cholesterol with human myeloperoxidase (MPO) in the presence of its substrates H(2)O(2) and Cl(-).	Water	150-155	myeloperoxidase	Homo sapiens	111-114
19478940-3	2009	Latherin produces a significant reduction in water surface tension at low concentrations (&lt; or = 1 mg ml(-1)), and therefore probably acts as a wetting agent to facilitate evaporative cooling through a waterproofed pelt.	Water	45-50	latherin	Equus caballus	0-8
19478940-5	2009	However, biophysical characterization (circular dichroism, differential scanning calorimetry) in solution shows that latherin behaves like a typical globular protein, although with unusual intrinsic fluorescence characteristics, suggesting that significant conformational change or unfolding of the protein is required for assembly of the air-water interfacial layer.	Water	343-348	latherin	Equus caballus	117-125
19450493-4	2009	Shearing of lysozyme in water altered the protein"s backbone structure, whereas similar shear rates in glycerol solution affected the solvent exposure of side-chain residues located toward the exterior of the lysozyme alpha-domain.	Water	24-29	lysozyme	Homo sapiens	12-20
19429284-4	2009	rE2/RSA loaded PLGA microspheres, with a mean diameter of 4 microm were obtained by a water in oil in water solvent extraction method (w/o/w).	Water	86-91	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	0-3
19429284-4	2009	rE2/RSA loaded PLGA microspheres, with a mean diameter of 4 microm were obtained by a water in oil in water solvent extraction method (w/o/w).	Water	102-107	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	0-3
19388688-4	2009	A spherical trapping potential was assigned to every SPC/E oxygen, thereby allowing the formation of protonated water molecules.	Water	112-117	proline rich protein gene cluster	Homo sapiens	53-56
19385626-0	2009	Theoretical and experimental studies of the conversion of chromopyrrolic acid to an antitumor derivative by cytochrome P450 StaP: the catalytic role of water molecules.	Water	152-157	cytoglobin	Homo sapiens	124-128
19385626-12	2009	Thus, the water diad emerges as the minimal requisite element that endows StaP with function.	Water	10-15	cytoglobin	Homo sapiens	74-78
19334782-1	2009	Fluorescence resonance energy transfer (FRET) between water-soluble conjugated polymer, poly-(9,9-bis(6"-N,N,N-trimethylammonium)-hexyl-fluorene phenylene) bromide, and ssDNA"s labeled with four different types of dyes (Pacific-blue, Alexa-fluor 430, Fluorescein, and ROX) has been investigated.	Water	54-59	MAX network transcriptional repressor	Homo sapiens	268-271
19269318-3	2009	Here we investigated the role of Cox-2 induced by hydrogen peroxide (H(2)O(2)), either exogenous or endogenously generated by TNFalpha, in the repair of a mechanically wounded HUVEC monolayer and probed the sources of H(2)O(2) that are involved in TNFalpha signaling and the pathways through which H(2)O(2) modulates Cox-2 expression.	Water	69-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	33-38
19442267-8	2009	RESULTS: Seventy percent ethanol-water extracts of ginseng significantly inhibited the transcription and secretion of CXCL-10 following TNF-alpha stimulation.	Water	33-38	tumor necrosis factor	Homo sapiens	136-145
18814960-0	2009	Aluminum drinking water treatment residuals (Al-WTRs) as sorbent for mercury: Implications for soil remediation.	Water	18-23	WTRS	Homo sapiens	48-52
19544888-1	2009	The preoxidation of As(III) to As(V) is a desirable process to increase the removal efficiency of arsenic in water treatment In this work, the photooxidation of As(III) under 254 nm irradiation was investigated in the concentration range of 1-1000 microM in the presence of potassium iodide (typically 100 microM).	Water	109-114	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	31-36
19544893-8	2009	The PCB bioaccumulation in marine clams was reduced when exposed to sediment treated with 2% AC in comparison to the control plot Field-deployed semi permeable membrane devices and polyethylene devices showed about 50% reduction in PCB uptake in AC-treated sediment and similar reduction in estimated pore-water PCB concentration.	Water	306-311	pyruvate carboxylase	Homo sapiens	4-7
19544893-13	2009	The reductions in PCB availability observed with slow mass transfer under field conditions calls for predictive models to assess the long-term trends in pore-water PCB concentrations and the benefits of alternative in-situ AC application and mixing strategies.	Water	158-163	pyruvate carboxylase	Homo sapiens	18-21
19442627-11	2009	MnSOD activity was rescued by the addition of MnCl(2) to Grx5 shRNA osteoblasts in the presence of H(2)O(2).	Water	99-104	superoxide dismutase 2, mitochondrial	Mus musculus	0-5
19425788-8	2009	A flexible water model, extending the rigid SPC/E, is proposed, which incorporates Lennard-Jones interactions centered on the hydrogen atoms.	Water	11-16	proline rich protein gene cluster	Homo sapiens	44-47
19383790-4	2009	Unlike the case in the structures of water-selective AQPs AqpZ and AQP1, the asparagines of the 2 Asn-Pro-Ala motifs do not hydrogen bond to the same water molecule; instead, they bond to 2 different water molecules in the center of the channel.	Water	37-42	aquaporin 1 (Colton blood group)	Homo sapiens	67-71
19430149-1	2009	A sensitive sensor for the determination of hydrogen peroxide (H(2)O(2)) was fabricated by immobilizing cytochrome c (cyt c) on binary self-assembled monolayers (SAMs) of 5-(1,2-dithiolan-3-yl)valeric acid (thioctic acid, T-COOH) and 5-(1,2-dithiolan-3-yl)valeramide (thioctic acid amide, T-NH(2)) on gold electrodes.	Water	63-68	cytochrome c, somatic	Homo sapiens	104-116
19430149-1	2009	A sensitive sensor for the determination of hydrogen peroxide (H(2)O(2)) was fabricated by immobilizing cytochrome c (cyt c) on binary self-assembled monolayers (SAMs) of 5-(1,2-dithiolan-3-yl)valeric acid (thioctic acid, T-COOH) and 5-(1,2-dithiolan-3-yl)valeramide (thioctic acid amide, T-NH(2)) on gold electrodes.	Water	63-68	cytochrome c, somatic	Homo sapiens	118-123
19442627-11	2009	MnSOD activity was rescued by the addition of MnCl(2) to Grx5 shRNA osteoblasts in the presence of H(2)O(2).	Water	99-104	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	57-61
19347962-4	2009	Specifically, AQP9 in a physiological context controls transmembrane water fluxes driving membrane protrusion formation, as an initial cellular response to a chemoattractant or other migratory signals.	Water	69-74	aquaporin 9	Homo sapiens	14-18
19337691-1	2009	L-xylulose reductase (XR) is involved in water re-absorption and cellular osmoregulation.	Water	41-46	dicarbonyl and L-xylulose reductase	Homo sapiens	0-20
19337691-1	2009	L-xylulose reductase (XR) is involved in water re-absorption and cellular osmoregulation.	Water	41-46	dicarbonyl and L-xylulose reductase	Homo sapiens	22-24
19251304-3	2009	The results of the PCB fate model highlighted that these processes play a key role for the settling of particles and consequently for the distribution of PCBs in the water column as well as for the contaminant flux at the sediment-water interface.	Water	166-171	pyruvate carboxylase	Homo sapiens	19-22
19251304-3	2009	The results of the PCB fate model highlighted that these processes play a key role for the settling of particles and consequently for the distribution of PCBs in the water column as well as for the contaminant flux at the sediment-water interface.	Water	231-236	pyruvate carboxylase	Homo sapiens	19-22
19347962-5	2009	The importance of AQP-facilitated water fluxes in directional cell motility is underscored by the observation that blocking or modifying specific sites in AQP9 also interferes with the molecular machinery that govern actin-mediated cellular shape changes.	Water	34-39	aquaporin 9	Homo sapiens	155-159
19251304-4	2009	On the air-water front, the simulations emphasised that the net atmospheric PCB input fluxes are generally more important during the cold season and show peaks during periods of high wet deposition.	Water	11-16	pyruvate carboxylase	Homo sapiens	76-79
19420793-4	2009	The pegylated insulin/CyD polypseudorotaxanes were less soluble in water.	Water	67-72	insulin	Homo sapiens	14-21
19106215-8	2009	Water restriction for 6 d increased plasma arginine vasopressin (AVP), ACTH, and adrenal and plasma corticosterone in both groups.	Water	0-5	arginine vasopressin	Rattus norvegicus	52-63
19379124-1	2009	Arginine vasopressin, also known as antidiuretic hormone, is a neuropeptide that functions in the maintenance of body water homeostasis.	Water	118-123	arginine vasopressin	Homo sapiens	9-20
19379124-1	2009	Arginine vasopressin, also known as antidiuretic hormone, is a neuropeptide that functions in the maintenance of body water homeostasis.	Water	118-123	arginine vasopressin	Homo sapiens	36-56
19476498-2	2009	Previously, we have shown that heat shock pretreatment blocked the release of the second mitochondria-derived activator of caspase (Smac) to the cytosol and inhibited apoptosis of C2C12 myoblast cells in response to H(2)O(2).	Water	216-221	diablo, IAP-binding mitochondrial protein	Mus musculus	82-130
19476498-2	2009	Previously, we have shown that heat shock pretreatment blocked the release of the second mitochondria-derived activator of caspase (Smac) to the cytosol and inhibited apoptosis of C2C12 myoblast cells in response to H(2)O(2).	Water	216-221	diablo, IAP-binding mitochondrial protein	Mus musculus	132-136
19151394-7	2009	Furthermore, HMGB-1 and RAGE were found in inflammatory cells infiltrating the anterior chamber, vitreous cavity, and subretinal space in EAU-induced rats.	Water	138-141	advanced glycosylation end product-specific receptor	Rattus norvegicus	24-28
19297589-2	2009	Pulsed-field gel electrophoresis analysis confirmed that the source of the organism was the patient"s newly purchased hot tub, which was filled with water from a stream.	Water	149-154	TUB bipartite transcription factor	Homo sapiens	122-125
19021293-6	2009	In addition, peripheral neprilysin expression reduced amyloid-dependent performance deficits as measured by the Morris water maze.	Water	119-124	membrane metalloendopeptidase	Homo sapiens	24-34
19410080-5	2009	We also found that LPS-induced expression of COX-2, IL-6, and TNF-alpha and p38 activation were markedly suppressed when LPS was pretreated with ozonated water.	Water	154-159	prostaglandin-endoperoxide synthase 2	Homo sapiens	45-50
19410080-5	2009	We also found that LPS-induced expression of COX-2, IL-6, and TNF-alpha and p38 activation were markedly suppressed when LPS was pretreated with ozonated water.	Water	154-159	interleukin 6	Homo sapiens	52-56
19410080-5	2009	We also found that LPS-induced expression of COX-2, IL-6, and TNF-alpha and p38 activation were markedly suppressed when LPS was pretreated with ozonated water.	Water	154-159	tumor necrosis factor	Homo sapiens	62-71
19410080-5	2009	We also found that LPS-induced expression of COX-2, IL-6, and TNF-alpha and p38 activation were markedly suppressed when LPS was pretreated with ozonated water.	Water	154-159	mitogen-activated protein kinase 14	Homo sapiens	76-79
19523574-3	2009	Exercise-associated hyponatremia (EAH) is caused by a combination of excessive water or hypotonic fluid intake as well as high levels of arginine vasopressin, which limits the ability of the kidney to excrete water.	Water	209-214	arginine vasopressin	Homo sapiens	146-157
19217736-0	2009	Role of excipients in the quantification of water in lyophilised mixtures using NIR spectroscopy.	Water	44-49	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	80-83
19217736-11	2009	It can therefore be concluded the NIR is a suitable tool for quantification of the water content in lyophilised samples with varying mannitol-sucrose ratios.	Water	83-88	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	34-37
19523575-6	2009	Inadvertent overcorrection owing to a water diuresis may complicate any form of therapy, including the newly available vasopressin antagonists.	Water	38-43	arginine vasopressin	Homo sapiens	119-130
21583812-2	2009	The Co(II) atom is located on an inversion center and is coordinated by six O atoms from two water mol-ecules and four mu(2)-carboxyl-ate groups of 4-fluoro-benzoate anions, forming a distorted CoO(6) octa-hedron, with Co-O bond lengths in the range 2.071 (2)-2.130 (2) A.	Water	93-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
19639693-2	2009	The mineral water was found to activate regulation of carbohydrate metabolism by insulin and cortisol due to the formation of adaptive reactions during a course of its therapeutic intake.	Water	12-17	insulin	Homo sapiens	81-88
19639693-3	2009	The mineral water promoted realization of trophic effects of gastrin and insulin in animals with peptic ulcer the size of which significantly decreased.	Water	12-17	insulin	Homo sapiens	73-80
18930783-1	2009	The Renin-Angiotensin System (RAS) is important for the regulation of cardiovascular physiology, where it controls blood pressure, and salt- and water homeostasis.	Water	145-150	renin	Homo sapiens	4-9
23818806-2	2009	His manner of antidiuretic hormone secretion was investigated by water loading and infusion of hypertonic saline to clarify the form of the syndrome of inappropriate antidiuretic hormone secretion.	Water	65-70	arginine vasopressin	Homo sapiens	14-34
19475943-3	2009	Kch (carbohydrates-water partition coefficient) and Klip could be estimated with the corresponding Kow values: log Kch = 1.23 log Kow - 2.42 and log Klip = 1.23 log Kow - 0.78.	Water	19-24	centromere protein U	Homo sapiens	149-157
19368448-4	2009	The potential energy barrier at the MP2/6-311++(3df,3pd)//MP2/6-31G(d,p) level was 4.8 kcal/mol for the triple proton transfer involving two water molecules with a rate constant of 1.6x10(3) s(-1) at 197 K. The potential energy curve near the saddle points was very flat and the tunneling effect on the proton transfer was negligible.	Water	141-146	major intrinsic protein of lens fiber	Homo sapiens	36-41
19317484-1	2009	Cytochrome c oxidase (CcO) catalyzes the four-electron reduction of oxygen to water, the one-electron reductant Cytochrome c (Cytc) being the source of electrons.	Water	78-83	cytochrome c, somatic	Homo sapiens	0-12
19317484-1	2009	Cytochrome c oxidase (CcO) catalyzes the four-electron reduction of oxygen to water, the one-electron reductant Cytochrome c (Cytc) being the source of electrons.	Water	78-83	cytochrome c, somatic	Homo sapiens	112-124
19317484-1	2009	Cytochrome c oxidase (CcO) catalyzes the four-electron reduction of oxygen to water, the one-electron reductant Cytochrome c (Cytc) being the source of electrons.	Water	78-83	cytochrome c, somatic	Homo sapiens	126-130
19355766-1	2009	Here we report on the polarization dependent nonresonant second harmonic generation (SHG) measurement of the interfacial water molecules at the aqueous solution of the following salts: NaF, NaCl, NaBr, KF, KCl, and KBr.	Water	121-126	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
19275182-1	2009	Atomic force microscopy (AFM) was used to analyze the interactions between fibrinogen and model surfaces having different levels of water wettability.	Water	132-137	fibrinogen beta chain	Homo sapiens	75-85
19348742-0	2009	Dynamics of the internal water molecules in squid rhodopsin.	Water	25-30	rhodopsin	Homo sapiens	50-59
19348742-5	2009	The crystal structure of the visual rhodopsin from squid solved recently suggests that a chain of water molecules extending from the retinal toward the cytoplasmic side of the protein may play a role in the signal transduction from the all-trans retinal geometry to the activated receptor.	Water	98-103	rhodopsin	Homo sapiens	36-45
19348742-6	2009	As a first step toward understanding the role of water in rhodopsin function, we performed a molecular dynamics simulation of squid rhodopsin embedded in a hydrated bilayer of polyunsaturated lipid molecules.	Water	49-54	rhodopsin	Homo sapiens	58-67
19355766-4	2009	Noticeably, both the cations and the anions contributed to the changes, and the abilities to increase the thickness of the interfacial water layer were in the following order: KBr &gt; NaBr &gt; KCl &gt; NaCl approximately NaF &gt; KF.	Water	135-140	C-X-C motif chemokine ligand 8	Homo sapiens	223-226
19355767-1	2009	Sum frequency generation vibrational spectra of the water molecules at the NaF and KF aqueous solution surfaces showed significantly different spectral features and different concentration dependence.	Water	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
19341409-6	2009	Only SOD activities of submersed plants were decreased with decline of SD in water (P &lt; 0.001).	Water	77-82	superoxide dismutase 1	Homo sapiens	5-8
19355940-5	2009	Among its inhibitory effects, CaSR modulates the signaling pathways used by the tubulocytes to activate electrolyte or water reabsorption.	Water	119-124	calcium sensing receptor	Homo sapiens	30-34
19355940-9	2009	CaSR also mediates the acute adverse renal effects of hypercalcemia, which include a reduced sodium, potassium and water reabsorption.	Water	115-120	calcium sensing receptor	Homo sapiens	0-4
19267429-3	2009	We studied the cis-trans isomerization of the proline dipeptide (Ace-Pro-NMe) in explicit water by molecular dynamics simulations using a combined potential derived from ab initio quantum mechanics and empirical molecular mechanics.	Water	90-95	angiotensin I converting enzyme	Homo sapiens	65-68
19399395-3	2009	Time-course analysis showed that the first signs of blood-brain barrier disruption and the increase of brain water content in LPS-treated animals were evident 6 h after LPS injection, with maximum value appearing at 12 h, which coincided with the expression profiles of AQP9 mRNA and protein in LPS-treated animals.	Water	109-114	aquaporin 9	Rattus norvegicus	270-274
19006274-1	2009	Distributions of binding energies of a water molecule in the water liquid-vapor interface are obtained on the basis of molecular simulation with the SPC/E model of water.	Water	39-44	proline rich protein gene cluster	Homo sapiens	149-152
19006274-1	2009	Distributions of binding energies of a water molecule in the water liquid-vapor interface are obtained on the basis of molecular simulation with the SPC/E model of water.	Water	61-66	proline rich protein gene cluster	Homo sapiens	149-152
19006274-1	2009	Distributions of binding energies of a water molecule in the water liquid-vapor interface are obtained on the basis of molecular simulation with the SPC/E model of water.	Water	61-66	proline rich protein gene cluster	Homo sapiens	149-152
19114109-3	2009	Here, we report the effect of inhibitors on water conduction by AQP4 and AQP1 reconstituted into liposomes.	Water	44-49	aquaporin 1 (Colton blood group)	Homo sapiens	73-77
19399395-4	2009	The further correlation analysis revealed strong positive correlations among the brain water content, the disruption of the blood-brain barrier and the enhanced expressions of AQP9 mRNA and protein in LPS-treated animals.	Water	87-92	aquaporin 9	Rattus norvegicus	176-180
19348229-1	2009	The octapeptide angiotensin II (AngII) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and contributes to the progression of cardiovascular remodeling.	Water	104-109	angiotensinogen	Homo sapiens	16-30
19092850-5	2009	TPA treatment decreased the expression level of catalase, which catalyzes the decomposition of hydrogen peroxide (H(2)O(2)) to H(2)O and O(2).	Water	114-119	catalase	Homo sapiens	48-56
19144785-8	2009	Next, we investigated the consequence of long-term nicotine exposure via the drinking water on nAChR-modulated responsiveness.	Water	86-91	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	95-100
19217659-3	2009	Third ventricle injections of IL-1beta significantly inhibited the increase in water intake observed in those situations.	Water	79-84	interleukin 1 beta	Rattus norvegicus	30-38
19217659-7	2009	Furthermore, the inhibitory effects of IL-1beta on water intake cannot be attributed to sickness-like effects induced by these compounds, since an aversion test excluded this possibility.	Water	51-56	interleukin 1 beta	Rattus norvegicus	39-47
19348229-1	2009	The octapeptide angiotensin II (AngII) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and contributes to the progression of cardiovascular remodeling.	Water	104-109	angiotensinogen	Homo sapiens	32-37
19034495-1	2009	In eye core lens membranes, aquaporin-0 (AQP0) and connexins (Cx) form together well-structured supramolecular assemblies, the junctional microdomains, in which they assure water, ion, metabolite, and waste transport.	Water	173-178	major intrinsic protein of lens fiber	Homo sapiens	28-39
19356308-7	2009	Between exposure and re-exposure, rats drank tap water for 4 days.	Water	49-54	nuclear RNA export factor 1	Rattus norvegicus	45-48
19034495-1	2009	In eye core lens membranes, aquaporin-0 (AQP0) and connexins (Cx) form together well-structured supramolecular assemblies, the junctional microdomains, in which they assure water, ion, metabolite, and waste transport.	Water	173-178	major intrinsic protein of lens fiber	Homo sapiens	41-45
19066926-0	2009	Ice as a water-equivalent solid medium for brachytherapy dosimetric measurements.	Water	9-14	carboxylesterase 2	Homo sapiens	0-3
19066926-6	2009	Ice-to-water conversion factors are calculated at distances of 0.2-10 cm from the source, for six high- and low-energy photon-emitting brachytherapy sources and mono-energetic photons between 10 keV to 2.0 MeV.	Water	7-12	carboxylesterase 2	Homo sapiens	0-3
19135543-3	2009	Both activities depressed cough induced by inhalation of distilled water aerosol (fog).	Water	67-72	zinc finger protein, FOG family member 1	Homo sapiens	82-85
19164426-9	2009	We also confirmed that systemic administration of anti-il-6 receptor antibody ameliorates EAU By suppressing both systemic and regional TH17 responses.	Water	90-93	interleukin 6	Mus musculus	55-59
19302811-9	2009	Bcl-2 declined in myotubes by 61% and 69% after 24 or 96 h of treatment in 4 mM H(2)O(2), respectively.	Water	80-85	BCL2 apoptosis regulator	Homo sapiens	0-5
19288015-8	2009	Indomethacin in drinking water reversed the clone 20 induced decrease in body and fat weight and food intake, and simultaneously negated the clone 20 induced increase of SSAT expressions and decrease of ACC and malonyl-CoA amounts.	Water	25-30	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	219-222
19112175-6	2009	The compromised vesicle binding by mutants in the key asparate residues forming the structural Mg2+-aspartate-water network within the substrate binding domain revealed that interfacial binding of DgkB required a Mg2+-dependent conformational change.	Water	110-115	diacylglycerol kinase beta	Homo sapiens	197-201
19317549-1	2009	The photo-oxidation of water on the monoclinic P2(1)/nWO(3) (200, 020, and 002) surfaces is investigated using density functional theory calculations, employing the PW91-generalized gradient approximation, and the method developed by Norskov et al.	Water	23-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-52
19235991-4	2009	The analysis of the water flux through amorphous MXD6 membranes showed a plasticization phenomenon followed by a water-induced crystallization.	Water	20-25	MAX network transcriptional repressor	Homo sapiens	49-53
19235991-4	2009	The analysis of the water flux through amorphous MXD6 membranes showed a plasticization phenomenon followed by a water-induced crystallization.	Water	113-118	MAX network transcriptional repressor	Homo sapiens	49-53
19235991-7	2009	In terms of barrier properties for water and carbon dioxyde, MXD6 membrane crystallized at high temperature were more performant than water-induced crystallized ones.	Water	35-40	MAX network transcriptional repressor	Homo sapiens	61-65
19235991-7	2009	In terms of barrier properties for water and carbon dioxyde, MXD6 membrane crystallized at high temperature were more performant than water-induced crystallized ones.	Water	134-139	MAX network transcriptional repressor	Homo sapiens	61-65
19115825-3	2009	All MD production simulations were performed in the canonical (NVT) ensemble at a temperature of 298 K. Water was described by the extended simple point charge (SPC/E) model.	Water	104-109	proline rich protein gene cluster	Homo sapiens	161-164
19054710-1	2009	The interaction of a water-soluble cationic porphyrin, meso-tetrakis (4-N,N,N-trimethylanilinium) porphyrin (TMAP), with two proteins, bovine serum albumin (BSA) and human serum albumin (HSA), was studied by UV-vis absorption spectroscopy, fluorescence spectroscopy, fluorescence anisotropy and synchronous fluorescence spectroscopy at neutral aqueous solutions.	Water	21-26	cytoskeleton associated protein 2	Homo sapiens	109-113
19254023-2	2009	Here we report the identification of a multicolor set of water-soluble ODF dyes that display emission colors across the visible spectrum, and all of which can be simultaneously excited by long-wavelength UV light at 340-380 nm.	Water	57-62	outer dense fiber of sperm tails 1	Homo sapiens	71-74
19420447-7	2009	The vertical rate of growth can reach 300 nm min(-1) in an environment containing argon, hydrogen, and traces of water vapour.	Water	113-118	CD59 molecule (CD59 blood group)	Homo sapiens	45-51
19058957-2	2009	A microfluidic chip-based immunoassay with laser-induced fluorescence (LIF) detection based on the water-soluble denatured bovine serum albumin (dBSA)-coated CdTe quantum dots (QDs) was prepared for the ultrasensitive detection of 7-ACZP.	Water	99-104	albumin	Homo sapiens	130-143
19284994-6	2009	Superposition experiments to another human tRNA(Gly) microhelix and a detailed comparison of the RNA hydration patterns show a great number of water molecules with identical positions in both RNAs.	Water	143-148	mitochondrially encoded tRNA glycine	Homo sapiens	43-52
19144687-0	2009	Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating.	Water	84-89	aquaporin 2 S homeolog	Xenopus laevis	68-79
19095763-3	2009	Stool water content is increased and colonic motility is irregular in mice with a targeted deletion of SERT.	Water	6-11	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	103-107
19144687-1	2009	Arginine vasopressin (AVP)-regulated phosphorylation of the water channel aquaporin-2 (AQP2) at serine 256 (S256) is essential for its accumulation in the apical plasma membrane of collecting duct principal cells.	Water	60-65	aquaporin 2 S homeolog	Xenopus laevis	74-85
19144687-1	2009	Arginine vasopressin (AVP)-regulated phosphorylation of the water channel aquaporin-2 (AQP2) at serine 256 (S256) is essential for its accumulation in the apical plasma membrane of collecting duct principal cells.	Water	60-65	aquaporin 2 S homeolog	Xenopus laevis	87-91
19144687-3	2009	When expressed in Xenopus laevis oocytes, prevention of AQP2 phosphorylation at S256A (S256A-AQP2) reduced osmotic water permeability threefold compared with wild-type (WT) AQP2-injected oocytes.	Water	115-120	aquaporin 2 S homeolog	Xenopus laevis	56-60
19144687-3	2009	When expressed in Xenopus laevis oocytes, prevention of AQP2 phosphorylation at S256A (S256A-AQP2) reduced osmotic water permeability threefold compared with wild-type (WT) AQP2-injected oocytes.	Water	115-120	aquaporin 2 S homeolog	Xenopus laevis	93-97
19144687-3	2009	When expressed in Xenopus laevis oocytes, prevention of AQP2 phosphorylation at S256A (S256A-AQP2) reduced osmotic water permeability threefold compared with wild-type (WT) AQP2-injected oocytes.	Water	115-120	aquaporin 2 S homeolog	Xenopus laevis	93-97
19144687-5	2009	Similarly, oocytes expressing S264D-AQP2 and S269D-AQP2, mimicking AQP2 phosphorylated at these residues, had similar water permeabilities to WT-AQP2-expressing oocytes.	Water	118-123	aquaporin 2 S homeolog	Xenopus laevis	51-55
19354067-13	2009	CONCLUSIONS: These results suggest that exposure to toxin-producing microbial growth in a water-damaged building caused immunosuppression in nasal mucosa, leading to a decrease in neutrophil counts and tumor necrosis factor alpha levels.	Water	90-95	tumor necrosis factor	Homo sapiens	202-229
19144687-5	2009	Similarly, oocytes expressing S264D-AQP2 and S269D-AQP2, mimicking AQP2 phosphorylated at these residues, had similar water permeabilities to WT-AQP2-expressing oocytes.	Water	118-123	aquaporin 2 S homeolog	Xenopus laevis	51-55
19144687-5	2009	Similarly, oocytes expressing S264D-AQP2 and S269D-AQP2, mimicking AQP2 phosphorylated at these residues, had similar water permeabilities to WT-AQP2-expressing oocytes.	Water	118-123	aquaporin 2 S homeolog	Xenopus laevis	51-55
19252272-1	2009	Here we reviewed our recent work on the chronic effects of nicotine on the Na+ -Ca2+ exchanger (NCX) gene and protein expressions in various organs of rats treated with nicotine in the drinking water for 4-12 weeks.	Water	194-199	solute carrier family 8 member A1	Rattus norvegicus	75-94
19184071-1	2009	Aquaporin-3 (AQP3) is a water/glycerol transporting protein expressed strongly at the plasma membrane of keratinocytes.	Water	24-29	aquaporin 3	Mus musculus	0-11
19184071-1	2009	Aquaporin-3 (AQP3) is a water/glycerol transporting protein expressed strongly at the plasma membrane of keratinocytes.	Water	24-29	aquaporin 3	Mus musculus	13-17
19184071-2	2009	There is evidence for involvement of AQP3-facilitated water and glycerol transport in keratinocyte migration and proliferation, respectively.	Water	54-59	aquaporin 3	Mus musculus	37-41
18991813-9	2009	On the basis of our results, a catalytic mechanism is proposed for hPHPT1: the imidazole ring of His(53) serves as a general base to activate a water molecule, and the activated water would attack the substrate as a nucleophile in the catalysis; the positively charged side chain of Lys(21) can help stabilize the transition state.	Water	144-149	phosphohistidine phosphatase 1	Homo sapiens	67-73
18991813-9	2009	On the basis of our results, a catalytic mechanism is proposed for hPHPT1: the imidazole ring of His(53) serves as a general base to activate a water molecule, and the activated water would attack the substrate as a nucleophile in the catalysis; the positively charged side chain of Lys(21) can help stabilize the transition state.	Water	178-183	phosphohistidine phosphatase 1	Homo sapiens	67-73
19252272-1	2009	Here we reviewed our recent work on the chronic effects of nicotine on the Na+ -Ca2+ exchanger (NCX) gene and protein expressions in various organs of rats treated with nicotine in the drinking water for 4-12 weeks.	Water	194-199	solute carrier family 8 member A1	Rattus norvegicus	96-99
19438053-0	2009	Continuous mineralization of concentrated phenol dissolved in an electrolyte-containing tap water by integrating biological-photocatalytic treatment with TiO2 separation: utilization of sunlight and reuse of TiO2.	Water	92-97	SEC14 like lipid binding 2	Homo sapiens	88-91
18988262-0	2009	The activity of human CYP2D6 in low water organic solvents.	Water	36-41	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	22-28
18988262-3	2009	Our recent demonstration that the P450 enzymes CYP2D6 and CYP3A4 can function very well in biphasic solvent systems is one step towards overcoming this drawback, but is not practical when substrates or products are unstable in water, or with water-soluble products.	Water	227-232	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	47-53
18988262-3	2009	Our recent demonstration that the P450 enzymes CYP2D6 and CYP3A4 can function very well in biphasic solvent systems is one step towards overcoming this drawback, but is not practical when substrates or products are unstable in water, or with water-soluble products.	Water	227-232	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	58-64
18988262-3	2009	Our recent demonstration that the P450 enzymes CYP2D6 and CYP3A4 can function very well in biphasic solvent systems is one step towards overcoming this drawback, but is not practical when substrates or products are unstable in water, or with water-soluble products.	Water	242-247	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	47-53
18988262-3	2009	Our recent demonstration that the P450 enzymes CYP2D6 and CYP3A4 can function very well in biphasic solvent systems is one step towards overcoming this drawback, but is not practical when substrates or products are unstable in water, or with water-soluble products.	Water	242-247	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	58-64
18988262-6	2009	This study demonstrates the unexpected high tolerance of CYP2D6 to some low water organic solvents and provides an alternative strategy to facilitate the use of this enzyme in synthesis.	Water	76-81	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	57-63
19529843-0	2009	Effects of exogenous application of corticotropin-releasing hormone to slices of the olfactory cortex from rats with an active strategy of adaptive behavior on the water-immersion model of depression.	Water	164-169	corticotropin releasing hormone	Rattus norvegicus	36-67
19529851-4	2009	An increase in the width of aggregation curves was most pronounced in the system of 10(-4) M Fe(2+) and 10(-4) M H(2)O(2) with oxidized fibrinogen.	Water	113-119	fibrinogen beta chain	Homo sapiens	136-146
19438053-1	2009	The continuous mineralization of concentrated phenol (200 mg l(-1)) in an electrolyte-containing tap water was investigated using a biological-photocatalytic treatment integrated with TiO2 separation.	Water	101-106	SEC14 like lipid binding 2	Homo sapiens	97-100
19438053-3	2009	The mineralization of phenol in tap water and the reuse of TiO2 were conducted in a flow system in which a bioreactor is combined with a narrow tube photoreactor operated under single pass and circulative flows, and the sedimented TiO2 is recycled.	Water	36-41	SEC14 like lipid binding 2	Homo sapiens	32-35
19438053-4	2009	A high circulative flow rate prevented the TiO2 particles from coagulating due to the electrolytes in the tap water.	Water	110-115	SEC14 like lipid binding 2	Homo sapiens	106-109
19438053-5	2009	A flow-circulation-flow operation mode using the integrated biological-photocatalytic-TiO2 separation system was the optimum for treating the concentrated phenol in the electrolyte-containing tap water without interrupting the inflow of the wastewater and the discharge of the treated water.	Water	196-201	SEC14 like lipid binding 2	Homo sapiens	192-195
19161297-1	2009	Substitution of Co(III)-bound water by cyanide allows the rapid colorimetric detection of micromolar amounts of cyanide with cobalt corrinoids.	Water	30-35	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	16-22
19440430-4	2009	Skin lesions were strongly associated with well water arsenic and there was an elevated prevalence among residents with water arsenic exposures as low as 5 microg/L-10 microg/L.	Water	120-125	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	163-167
19192210-0	2009	Water-mediated spectral shifts in rhodopsin and bathorhodopsin.	Water	0-5	rhodopsin	Homo sapiens	34-43
19621569-1	2009	Aquaporin belongs to a highly conserved group of membrane proteins called major intrinsic proteins (MIPs) that facilitate water transport across biological membranes.	Water	122-127	aquaporin PIP2-7-like	Gossypium hirsutum	0-9
19022916-0	2009	Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK/HO-1 signalling and reduction of oxidative stress.	Water	0-5	heme oxygenase 1	Mus musculus	106-110
19087893-0	2009	Towards [Cp*Rh(bpy)(H2O]2+-promoted P450 catalysis: direct regeneration of CytC.	Water	20-23	cytochrome c, somatic	Homo sapiens	75-79
19209902-1	2009	Vasopressin-mediated control of water permeability in the renal collecting duct occurs in part through regulation of the distribution of aquaporin-2 (AQP2) between the apical plasma membrane and intracellular membrane compartments.	Water	32-37	arginine vasopressin	Rattus norvegicus	0-11
18800231-7	2009	The most predictive model of EPO response for the pediatric cohort had, as the major variables, urea clearance x dialysis duration/total body water (Kt/V), urea reduction ratio (URR), intact parathyroid hormone (iPTH), blood loss, normalized protein catabolic rates (nPCR) and indices of malnutrition and inflammation, whereas adults had iron and folate deficiencies as the dominant variables.	Water	142-147	erythropoietin	Homo sapiens	29-32
19084995-3	2009	Similarly, catalase (H(2)O(2) scavenger) or DPI [NAD(P)H oxidase inhibitor] and BAPTA-AM or BAPTA (calcium chelators) prevented chitosan induced stomatal closure, suggesting that reactive oxygen species (ROS) and calcium were involved during such response.	Water	21-26	catalase	Homo sapiens	11-19
19191527-0	2009	Computational modeling study on formation of acyclic clavulanate intermediates in inhibition of class A beta-lactamase: water-assisted proton transfer.	Water	120-125	amyloid beta precursor protein	Homo sapiens	102-108
19173595-5	2009	DXMS assesses relative rates of exchange of hydrogens of the polypeptide backbone of PE with deuterium atoms from D(2)O (heavy water) in solvent.	Water	127-132	proenkephalin	Homo sapiens	85-87
19190378-3	2009	In (I), two independent Co(II) ions are six-coordinated through N(3)O(3) donor sets in slightly distorted octahedral geometries provided by two carboxylate and three pyridine ligands, and one water molecule.	Water	192-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19262015-1	2009	Three constructs having mutated PKA-target motif at (152)SRRTS of AQP5, an exocrine type water channel, were prepared and fused to C-terminus of green fluorescence protein cDNA to examine the effects of blocking of phosphorylation at (152)SRRTS (a consensus PKA-target motif of AQP5) on translocation or trafficking of the chimeric proteins expressed in the Madin-Darby canine kidney-II (MDCK-II) cells.	Water	89-94	aquaporin 5	Canis lupus familiaris	66-70
18793836-0	2009	Removal of As(V) from water by pectin based active hydrogels following geochemical approach.	Water	22-27	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	11-16
18793836-1	2009	Fe(II)-loaded pectin based hydrogels were used to remove As(V) from water.	Water	68-73	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	57-62
18990514-6	2009	Acetone 1% in the tap water was used to induce brain CYP2E1.	Water	22-27	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	53-59
19114648-6	2009	Intracerebroventricular infusion of angiotensin II promoted mitochondrial ETC dysfunctions in Wistar-Kyoto rats, and coenzyme Q(10) or gene knockdown of the p22(phox) subunit of NADPH oxidase antagonized the resultant elevation of H(2)O(2) in RVLM.	Water	231-236	angiotensinogen	Rattus norvegicus	36-50
19201825-7	2009	Our data indicate that water-soluble analogs of the N-terminal segment of SP-C can reduce LPS effects in the presence of serum, and thus might help in the design of new derivatives to fight endotoxic shock and pro-inflammatory events.	Water	23-28	surfactant protein C	Homo sapiens	74-78
19108589-0	2009	Conserved water mediated H-bonding dynamics of inhibitor, cofactor, Asp 364 and Asn 303 in human IMPDH II.	Water	10-15	inosine monophosphate dehydrogenase 2	Homo sapiens	97-105
19108589-4	2009	The stereochemistry of the four- centered H-bonds around the conserved water center may be exploited to design a better model inhibitor for IMPDH-II.	Water	71-76	inosine monophosphate dehydrogenase 2	Homo sapiens	140-148
19015356-9	2009	The administration of 30 microg (1.5 mg/kg of body weight) (RXR)(4)XB-AcpP PMO at 15 min postinfection reduced CFU/ml in blood by 10(2) to 10(3) within 2 to 12 h compared to the numbers in water-treated controls.	Water	189-194	acid phosphatase, prostate	Mus musculus	70-74
18478369-0	2009	Adsorption behavior of lysozyme and Tween 80 at hydrophilic and hydrophobic silica-water interfaces.	Water	83-88	lysozyme	Homo sapiens	23-31
18478369-3	2009	Here, we describe the interaction of the well-characterized, globular protein lysozyme with Tween 80 at solid-water interfaces.	Water	110-115	lysozyme	Homo sapiens	78-86
19032361-2	2009	We previously reported that oral administration of a water-soluble extract prepared from Actinidia arguta, code-named PG102, could modulate the level of Th1 and Th2 cytokines and suppress the production of immunoglobulin E (IgE) in the ovalbumin (OVA)-immunized murine model as well as in the in vitro cell culture system, and furthermore could significantly improve dermatitis conditions in the NC/Nga murine model.	Water	53-58	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	236-245
19123102-10	2009	The amounts of toxic trace elements such as As, Se, Cd, Cr and Pb leached out of the fly ashes when in contact with de-mineralized water (DIN-S4 test) were low and below the Target Water Quality Range (TWQR) of South Africa.	Water	131-136	Axin	Drosophila melanogaster	138-141
18950781-0	2009	Effect of chloroform on complexation and chiral aggregation of bilirubin-bovine serum albumin at heptane/water interface.	Water	105-110	albumin	Homo sapiens	80-93
19073143-3	2009	The structures revealed that the mSULT1D1 contains an L-shaped accepter-binding site which comprises 20 amino acid residues and four conserved water molecules.	Water	143-148	sulfotransferase family 1D, member 1	Mus musculus	33-41
18550276-6	2009	The solution pH, zero point charge (pH(zpc)) and species distribution of Pb(II) and Pb(II)-CA were found to play an important role in the adsorption of Pb(II) and Pb(II)-CA onto SDAC from water and wastewaters.	Water	188-193	submaxillary gland androgen regulated protein 3B	Homo sapiens	73-79
18550276-6	2009	The solution pH, zero point charge (pH(zpc)) and species distribution of Pb(II) and Pb(II)-CA were found to play an important role in the adsorption of Pb(II) and Pb(II)-CA onto SDAC from water and wastewaters.	Water	188-193	submaxillary gland androgen regulated protein 3B	Homo sapiens	84-90
18550276-6	2009	The solution pH, zero point charge (pH(zpc)) and species distribution of Pb(II) and Pb(II)-CA were found to play an important role in the adsorption of Pb(II) and Pb(II)-CA onto SDAC from water and wastewaters.	Water	188-193	submaxillary gland androgen regulated protein 3B	Homo sapiens	84-90
18550276-6	2009	The solution pH, zero point charge (pH(zpc)) and species distribution of Pb(II) and Pb(II)-CA were found to play an important role in the adsorption of Pb(II) and Pb(II)-CA onto SDAC from water and wastewaters.	Water	188-193	submaxillary gland androgen regulated protein 3B	Homo sapiens	84-90
18835571-7	2009	The results of Experiment 4 demonstrate that intraperitoneal injection of CGRP also causes reduced food and water intake.	Water	108-113	calcitonin related polypeptide alpha	Homo sapiens	74-78
18843259-1	2009	Trafficking of the water channel aquaporin-2 to the apical plasma membrane of the collecting duct is mediated by arginine vasopressin, rendering the cell permeable to water.	Water	19-24	arginine vasopressin	Rattus norvegicus	122-133
18843259-1	2009	Trafficking of the water channel aquaporin-2 to the apical plasma membrane of the collecting duct is mediated by arginine vasopressin, rendering the cell permeable to water.	Water	167-172	arginine vasopressin	Rattus norvegicus	122-133
18662282-0	2009	Peritoneal sepsis downregulates liver expression of Aquaporin-8: a water channel involved in bile secretion.	Water	67-72	aquaporin 8	Homo sapiens	52-63
19075008-10	2009	CD63 knockout mice show an increased urinary flow, water intake, reduced urine osmolality, and a higher fecal water content.	Water	51-56	CD63 antigen	Mus musculus	0-4
19075008-10	2009	CD63 knockout mice show an increased urinary flow, water intake, reduced urine osmolality, and a higher fecal water content.	Water	110-115	CD63 antigen	Mus musculus	0-4
18816698-1	2009	BACKGROUND: To estimate the response rate and therapy related toxicities of the anti-CD20 monoclonal antibody rituximab when combined with chemotherapy including ifosfamide, carboplatin, and etoposide (ICE) in patients with relapsed and refractory B-cell non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia (B-ALL).	Water	202-205	keratin 20	Homo sapiens	85-89
18726924-6	2009	Here it is demonstrated that Bio 30, a CAPE-rich water-miscible extract of New Zealand (NZ) propolis suppressed completely the growth of a human NF1 cancer called MPNST (malignant peripheral nerve sheath tumor) and caused an almost complete regression of human NF2 tumor (Schwannoma), both grafted in nude mice.	Water	49-54	neurofibromin 1	Homo sapiens	145-148
19270200-9	2009	During PD, AQP1 plays an essential role in water permeability and ultrafiltration (UF), modulating processes such as endothelial permeability and angiogenesis.	Water	43-48	aquaporin 1 (Colton blood group)	Homo sapiens	11-15
19042137-7	2009	ABA-induced SOD and CAT activities could be blocked by scavengers of H(2)O(2) and NO, and inhibitors of H(2)O(2) and NO generation.	Water	69-74	superoxide dismutase 1	Homo sapiens	12-15
19042137-7	2009	ABA-induced SOD and CAT activities could be blocked by scavengers of H(2)O(2) and NO, and inhibitors of H(2)O(2) and NO generation.	Water	69-74	catalase	Homo sapiens	20-23
19042137-7	2009	ABA-induced SOD and CAT activities could be blocked by scavengers of H(2)O(2) and NO, and inhibitors of H(2)O(2) and NO generation.	Water	104-109	superoxide dismutase 1	Homo sapiens	12-15
19042137-7	2009	ABA-induced SOD and CAT activities could be blocked by scavengers of H(2)O(2) and NO, and inhibitors of H(2)O(2) and NO generation.	Water	104-109	catalase	Homo sapiens	20-23
19042137-10	2009	SOD and CAT induced by H(2)O(2) could be blocked by scavenger of NO and inhibitors of NO generation, while SOD and CAT induced by NO could not be blocked by scavenger of H(2)O(2) and inhibitor of H(2)O(2).	Water	23-28	superoxide dismutase 1	Homo sapiens	0-3
19042137-10	2009	SOD and CAT induced by H(2)O(2) could be blocked by scavenger of NO and inhibitors of NO generation, while SOD and CAT induced by NO could not be blocked by scavenger of H(2)O(2) and inhibitor of H(2)O(2).	Water	23-28	catalase	Homo sapiens	8-11
19042137-11	2009	The results revealed that ABA-induced SOD and CAT activities were mediated sequentially by H(2)O(2) and NO, and NO acted downstream of H(2)O(2).	Water	91-96	superoxide dismutase 1	Homo sapiens	38-41
19042137-11	2009	The results revealed that ABA-induced SOD and CAT activities were mediated sequentially by H(2)O(2) and NO, and NO acted downstream of H(2)O(2).	Water	91-96	catalase	Homo sapiens	46-49
19038416-9	2009	In contrast, the NF-kappaB response was potentiated by exposure to water from both locations following activation of NF-kappaB by treatment with heat-killed Escherichia coli.	Water	67-72	nuclear factor kappa B subunit 1	Homo sapiens	17-26
19038416-9	2009	In contrast, the NF-kappaB response was potentiated by exposure to water from both locations following activation of NF-kappaB by treatment with heat-killed Escherichia coli.	Water	67-72	nuclear factor kappa B subunit 1	Homo sapiens	117-126
19132862-4	2009	These results not only are in accord with recent computer simulations indicating that the expulsion of interfacial water molecules is a key event in the dimerization/oligmerization of amyloid beta (Abeta) peptides but also have implications for amyloid formation in vivo where molecular crowding is expected to influence the solvation status of proteins.	Water	115-120	amyloid beta precursor protein	Homo sapiens	198-203
19084625-4	2009	The determination of the carbon isotope composition of DIC was clearly useful for distinguishing between naturally and artificially sparkling waters.	Water	142-148	solute carrier family 25 member 10	Homo sapiens	55-58
19132773-10	2009	CONCLUSION: A H pylori water extract reduces gastric mucosal blood flow acutely through iNOS- and nerve-mediated pathways.	Water	23-28	nitric oxide synthase 2, inducible	Mus musculus	88-92
26609818-1	2009	Kinetic isotope effects (KIEs) on the two alternative reactions, SN2 and E2, between hypochlorite anion and ethyl chloride in water have been studied theoretically using B3LYP and M06-2X functionals.	Water	126-131	solute carrier family 38 member 5	Homo sapiens	65-68
18790031-7	2009	This indicated a higher density of matrix structure formed between GSA and MAS, resulting in lower water uptake in an acidic medium.	Water	99-104	GNAS complex locus	Homo sapiens	67-70
19389608-2	2009	Sap is a dilute solution of primarily water and sucrose, with varying amounts of amino and organic acids and phenolic substances.	Water	38-43	SH2 domain containing 1A	Homo sapiens	0-3
19072146-0	2009	Driving force behind adsorption-induced protein unfolding: a time-resolved X-ray reflectivity study on lysozyme adsorbed at an air/water interface.	Water	131-136	lysozyme	Homo sapiens	103-111
25009942-0	2009	Contaminated Water Supplies at Camp Lejeune: Assessing Potential Health Effects In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in North Carolina were found to be contaminated with the industrial solvents trichloroethylene (TCE) and perchloroethylene (PCE).	Water	13-18	cathelicidin antimicrobial peptide	Homo sapiens	31-35
19027002-7	2009	Moreover, DMAI inhibited redox-sensitive activation of the PI3K/PTEN/Akt pathway and NF-kappaB activation in macrophages treated with H(2)O(2).	Water	134-139	phosphatase and tensin homolog	Mus musculus	64-68
19027002-7	2009	Moreover, DMAI inhibited redox-sensitive activation of the PI3K/PTEN/Akt pathway and NF-kappaB activation in macrophages treated with H(2)O(2).	Water	134-139	thymoma viral proto-oncogene 1	Mus musculus	69-72
19027002-7	2009	Moreover, DMAI inhibited redox-sensitive activation of the PI3K/PTEN/Akt pathway and NF-kappaB activation in macrophages treated with H(2)O(2).	Water	134-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94
19118280-0	2009	Suppression of peroxisome proliferator-activated receptor-gamma activity by angiotensin II in vascular smooth muscle involves Bcr kinase: the fire that drowns the water.	Water	163-168	peroxisome proliferator activated receptor gamma	Homo sapiens	15-63
19118280-0	2009	Suppression of peroxisome proliferator-activated receptor-gamma activity by angiotensin II in vascular smooth muscle involves Bcr kinase: the fire that drowns the water.	Water	163-168	angiotensinogen	Homo sapiens	76-90
19412798-0	2009	Plasma vasopressin, oxytocin, estradiol, and progesterone related to water and sodium excretion in normal pregnancy and gestational hypertension.	Water	69-74	arginine vasopressin	Homo sapiens	7-18
19412798-1	2009	OBJECTIVE: To investigate associations between plasma oxytocin and vasopressin concentrations and renal water and sodium excretion during normal pregnancy in comparison with gestational hypertension.	Water	104-109	arginine vasopressin	Homo sapiens	67-78
18945830-11	2009	We conclude that changes in CLC-K1, UT-A1, UT-A3, and TonEBP play important roles in the renal response to osmotic diuresis in an attempt to minimize changes in plasma osmolality and maintain water homeostasis.	Water	192-197	chloride voltage-gated channel Ka	Rattus norvegicus	28-34
18948439-0	2009	Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport.	Water	91-96	aquaporin 8	Homo sapiens	24-35
18948439-1	2009	Aquaporin-8 (AQP8) water channels, which are expressed in rat hepatocyte bile canalicular membranes, are involved in water transport during bile formation.	Water	19-24	aquaporin 8	Rattus norvegicus	0-11
18948439-1	2009	Aquaporin-8 (AQP8) water channels, which are expressed in rat hepatocyte bile canalicular membranes, are involved in water transport during bile formation.	Water	19-24	aquaporin 8	Rattus norvegicus	13-17
18948439-1	2009	Aquaporin-8 (AQP8) water channels, which are expressed in rat hepatocyte bile canalicular membranes, are involved in water transport during bile formation.	Water	117-122	aquaporin 8	Rattus norvegicus	0-11
18948439-1	2009	Aquaporin-8 (AQP8) water channels, which are expressed in rat hepatocyte bile canalicular membranes, are involved in water transport during bile formation.	Water	117-122	aquaporin 8	Rattus norvegicus	13-17
18948439-3	2009	In this study, we directly evaluated whether AQP8 gene silencing by RNA interference inhibits canalicular water secretion in the human hepatocyte-derived cell line, HepG2.	Water	106-111	aquaporin 8	Homo sapiens	45-49
18948439-7	2009	We found that AQP8 knockdown cells showed a significant decline in the canalicular volume of approximately 70% (P &lt; 0.01), suggesting an impairment in the basal (nonstimulated) canalicular water movement.	Water	192-197	aquaporin 8	Homo sapiens	14-18
18948439-8	2009	We also found that the decreased AQP8 expression inhibited the canalicular water transport in response either to an inward osmotic gradient (-65%, P &lt; 0.05) or to the bile secretory agonist dibutyryl cAMP (-80%, P &lt; 0.05).	Water	75-80	aquaporin 8	Homo sapiens	33-37
18948439-9	2009	Our data suggest that AQP8 plays a major role in water transport across canalicular membrane of HepG2 cells and support the notion that defective expression of AQP8 causes bile secretory dysfunction in human hepatocytes.	Water	49-54	aquaporin 8	Homo sapiens	22-26
19201744-4	2009	The hindlimb unloaded rats maintained on tap water had significantly elevated MDA levels in 7 tissues (brain, lung, pancreas, kidney, intestine, heart, liver) when compared to the paired hindlimb loaded controls (p &lt;0.05).	Water	45-50	nuclear RNA export factor 1	Rattus norvegicus	41-44
18096255-8	2009	The water drinking and gargling function tests showed a strong correlation (p&lt;0.001) with cognitive function and ADL.	Water	4-9	sarcoglycan alpha	Homo sapiens	116-119
19462786-1	2009	Effects of desmopressin, a synthetic analog of antidiuretic hormone (ADH), on water-salt metabolism and orthostatic tolerance were evaluated in human subjects during 24-hr HDT (-15 degrees).	Water	78-83	arginine vasopressin	Homo sapiens	69-72
19117492-2	2009	A series of single photon emission computed tomography imaging agents (SPECT) utilizing the organometallic radioactive imaging species, fac-99mTc(OH(2))(3)(CO)(3)+, were prepared on the basis of the structure of Flutamide, a potent nonsteroidal antiandrogen prostate cancer drug.	Water	146-151	FA complementation group C	Homo sapiens	136-139
18829705-2	2009	Aquaporin 9 (AQP9) is the main water channel in the epididymis, but its regulation is still poorly understood.	Water	31-36	aquaporin 9	Rattus norvegicus	0-11
18829705-2	2009	Aquaporin 9 (AQP9) is the main water channel in the epididymis, but its regulation is still poorly understood.	Water	31-36	aquaporin 9	Rattus norvegicus	13-17
18838162-5	2009	The micelles were prepared through a co-micellization of PLGA-b-PPO-b-PLGA (PPO: poly(propylene oxide)) and PEG-b-PPO in water.	Water	121-126	protoporphyrinogen oxidase	Homo sapiens	64-67
19621136-6	2009	The results obtained indicated that ethanolic extract has more potent hepatoprotective action than water extract against CC1(4) by lowering the MDA level and elevating antioxidants enzymes activities (SOD and CAT).	Water	99-104	catalase	Rattus norvegicus	209-212
18926940-9	2009	PTH (p=0.022) and S-CTX (p=0.023) decreased with water B but not with water A.	Water	49-54	parathyroid hormone	Homo sapiens	0-3
19373924-1	2009	The conformational study of N-acetyl-N"-methylamide of L-3,4-dehydroproline (Ac-Dhp-NHMe, the Dhp dipeptide) is carried out using hybrid density functional methods with the self-consistent reaction field method in the gas phase and in solution (chloroform and water).	Water	260-265	dihydropyrimidinase	Homo sapiens	80-83
19373924-1	2009	The conformational study of N-acetyl-N"-methylamide of L-3,4-dehydroproline (Ac-Dhp-NHMe, the Dhp dipeptide) is carried out using hybrid density functional methods with the self-consistent reaction field method in the gas phase and in solution (chloroform and water).	Water	260-265	dihydropyrimidinase	Homo sapiens	94-97
19373924-3	2009	For local minima of the Dhp dipeptide in the gas phase and in water, the C(beta)-C(gamma) bonds become shorter by approximately 0.2 A and the bond angles C(alpha)-C(beta)-C(gamma) and C(beta)-C(gamma)-C(delta) are widened by approximately 8 degrees than those of the Pro dipeptide, and the puckering amplitude is computed to be 0.01-0.07 A, indicating that the 3,4-dehydroprolyl ring is quite less puckered.	Water	62-67	dihydropyrimidinase	Homo sapiens	24-27
19373924-5	2009	The barriers to cis-trans isomerization of the Ac-Dhp peptide bond increase with the increase of solvent polarity and the isomerization is likely to proceed through the clockwise rotation in water, as found for the prolyl peptide bond.	Water	191-196	dihydropyrimidinase	Homo sapiens	50-53
19728302-10	2009	CD spectra showed that although both AII and TOAC1-AII presented flexible conformations in water, TOAC3-AII displayed conformational restriction because of the TOAC-imposed bend (Schreier et al., Biopolymers 2004, 74, 389).	Water	91-96	angiotensinogen	Homo sapiens	37-40
19728302-10	2009	CD spectra showed that although both AII and TOAC1-AII presented flexible conformations in water, TOAC3-AII displayed conformational restriction because of the TOAC-imposed bend (Schreier et al., Biopolymers 2004, 74, 389).	Water	91-96	angiotensinogen	Homo sapiens	51-54
19728302-10	2009	CD spectra showed that although both AII and TOAC1-AII presented flexible conformations in water, TOAC3-AII displayed conformational restriction because of the TOAC-imposed bend (Schreier et al., Biopolymers 2004, 74, 389).	Water	91-96	angiotensinogen	Homo sapiens	51-54
19346743-0	2009	Relationship between extracellular water fraction of total body water estimated by bioimpedance spectroscopy and cardiac troponin T in chronic haemodialysis patients.	Water	35-40	troponin T2, cardiac type	Homo sapiens	113-131
19346743-0	2009	Relationship between extracellular water fraction of total body water estimated by bioimpedance spectroscopy and cardiac troponin T in chronic haemodialysis patients.	Water	64-69	troponin T2, cardiac type	Homo sapiens	113-131
18926940-10	2009	CONCLUSION: In calcium sufficiency, the acid calcium-rich water had no effect on bone resorption, while the alkaline water rich in bicarbonate led to a significant decrease of PTH and of S-CTX.	Water	117-122	parathyroid hormone	Homo sapiens	176-179
18974231-5	2009	Tissue aromatase activity was determined by the tritiated ((3)H)-water method.	Water	65-70	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	7-16
19092365-1	2009	Antidiuretic hormone, also known as arginine vasopressin, is a hormone with a multitude of physiologic activities including the control of urinary free water excretion.	Water	152-157	arginine vasopressin	Homo sapiens	0-20
19092365-1	2009	Antidiuretic hormone, also known as arginine vasopressin, is a hormone with a multitude of physiologic activities including the control of urinary free water excretion.	Water	152-157	arginine vasopressin	Homo sapiens	45-56
19035614-0	2009	Syntheses of high-valent fac-[99mTcO3]+ complexes and [3+2] cycloadditions with alkenes in water as a direct labelling strategy.	Water	91-96	FA complementation group C	Homo sapiens	25-28
19860701-7	2009	Decreased levels of gastric CGRP-like immunoreactivity (li) were observed during acetic acid-, cysteamine-, concentrated ethanol- or water immersion stress-ulcers.	Water	133-138	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	28-32
20408502-3	2009	Both substrate binding to CYP2F2 and metabolic clearance by CYP2F enzymes correlate with the lipophilicity, parameter, log P (where P is the octanol/water partition coefficient of the substrate).	Water	149-154	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	26-31
19035614-2	2009	We developed convenient reactions for the synthesis of small, water stable fac-[TcO(3)(tacn-R)](+) complexes ((99)Tc and (99m)Tc, tacn = 1,4,7-triazacyclononane, R = H, -CH(2)-C(6)H(5), -CH(2)-C(6)H(4)COOH).	Water	62-67	FA complementation group C	Homo sapiens	75-78
19713609-2	2009	In medicine and biotechnology the permeability is given usually as the amount of water (ml x cm(-2) x min(-1)) permeating per area and time unit through the material.	Water	81-86	CD59 molecule (CD59 blood group)	Homo sapiens	102-108
19096783-7	2009	Crystallography studies support the notion of the double function of aquaporin 0 as a water channel (open configuration) or adhesion molecule (closed configuration) in the ocular lens fibers.	Water	86-91	major intrinsic protein of lens fiber	Mus musculus	69-80
18723579-0	2009	Angiotensin II stimulates water and NaCl intake through separate cell signalling pathways in rats.	Water	26-31	angiotensinogen	Rattus norvegicus	0-14
18723579-1	2009	Angiotensin II (AngII) stimulation of water and NaCl intake is a classic model of the behavioural effects of hormones.	Water	38-43	angiotensinogen	Rattus norvegicus	0-14
18723579-1	2009	Angiotensin II (AngII) stimulation of water and NaCl intake is a classic model of the behavioural effects of hormones.	Water	38-43	angiotensinogen	Rattus norvegicus	16-21
18723579-3	2009	Previous studies support the hypotheses that PKC is involved in AngII-induced water, but not NaCl intake and that MAP kinase plays a role in NaCl consumption, but not water intake, after injection of AngII.	Water	78-83	angiotensinogen	Rattus norvegicus	64-69
18723579-5	2009	Pretreatment with the PKC inhibitor chelerythrine attenuated AngII-induced water intake, but NaCl intake was unaffected.	Water	75-80	angiotensinogen	Rattus norvegicus	61-66
19096773-8	2009	We also summarize data on the modification of pore selectivity of the prototypical water-specific mammalian aquaporin-1.	Water	83-88	aquaporin 1 (Colton blood group)	Homo sapiens	108-119
19089329-7	2009	cGKI relaxes smooth muscle tone and prevents platelet aggregation, whereas cGKII inhibits renin secretion, chloride/water secretion in the small intestine, the resetting of the clock during early night, and endochondreal bone growth.	Water	116-121	protein kinase cGMP-dependent 2	Homo sapiens	75-80
19096783-8	2009	The functions of MIP/AQP0, both as a water channel and an adhesive molecule in the lens fibers, contribute to the narrow intercellular space of the lens fibers that is required for lens transparency and accommodation.	Water	37-42	major intrinsic protein of lens fiber	Mus musculus	17-20
19096775-12	2009	Such drugs may be suitable for the treatment of diseases associated with dysregulation of body water homeostasis, including NDI or cardiovascular diseases (e.g., chronic heart failure) where the AVP level is elevated, inducing excessive water retention.	Water	95-100	arginine vasopressin	Homo sapiens	195-198
19096783-8	2009	The functions of MIP/AQP0, both as a water channel and an adhesive molecule in the lens fibers, contribute to the narrow intercellular space of the lens fibers that is required for lens transparency and accommodation.	Water	37-42	major intrinsic protein of lens fiber	Mus musculus	21-25
19096784-4	2009	AQP1 is present in both apical and basolateral membranes of proximal tubules, and in descending limbs of Henle"s loop where 70% of filtrated water is isoosmotically reabsorbed (King and Agre 1996).	Water	141-146	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
19096783-5	2009	Besides functioning as a water channel, aquaporin 0 also plays a structural role, being required for maintaining the transparency and optical accommodation of the ocular lens.	Water	25-30	major intrinsic protein of lens fiber	Mus musculus	40-51
19096784-5	2009	AQP2 is expressed in principal cells of the collecting duct; in response to vasopressin, AQP2 translocates from intracellular vesicles to the apical plasma membranes, thereby increasing water permeability to concentrate urine (Nielsen et al.	Water	186-191	arginine vasopressin	Homo sapiens	76-87
19607981-2	2009	Superoxide anion is converted by superoxide dismutase into hydrogen peroxide (H2O2), and the latter is then transformed into the toxic hydroxyl radical, through the Haber-Weiss reaction, converted to water by glutathione peroxidase (GPx) or dismuted to water and oxygen through catalase.	Water	200-205	catalase	Rattus norvegicus	278-286
18983920-0	2009	A water-specific aquaporin involved in aphid osmoregulation.	Water	2-7	aquaporin	Acyrthosiphon pisum	17-26
18983920-2	2009	Water cycling from the distal to proximal regions of the gut is believed to contribute to the osmoregulation of aphids and other phloem-feeding insects, with the high flux of water mediated by a membrane-associated aquaporin.	Water	0-5	aquaporin	Acyrthosiphon pisum	215-224
18983920-2	2009	Water cycling from the distal to proximal regions of the gut is believed to contribute to the osmoregulation of aphids and other phloem-feeding insects, with the high flux of water mediated by a membrane-associated aquaporin.	Water	175-180	aquaporin	Acyrthosiphon pisum	215-224
18983920-5	2009	Molecular modeling suggests that ApAQP1 has the general aquaporin topology and possesses the conserved pore properties of water-specific aquaporins.	Water	122-127	aquaporin	Acyrthosiphon pisum	33-39
18983920-6	2009	When expressed in Xenopus oocytes, ApAQP1 showed the hallmarks of aquaporin-mediated water transport, including an 18-fold increase in the osmotic water permeability of the oolemma, a reduced activation energy, and inhibition of elevated water transport activity by Hg ions.	Water	85-90	aquaporin	Acyrthosiphon pisum	35-41
18983920-6	2009	When expressed in Xenopus oocytes, ApAQP1 showed the hallmarks of aquaporin-mediated water transport, including an 18-fold increase in the osmotic water permeability of the oolemma, a reduced activation energy, and inhibition of elevated water transport activity by Hg ions.	Water	147-152	aquaporin	Acyrthosiphon pisum	35-41
18983920-6	2009	When expressed in Xenopus oocytes, ApAQP1 showed the hallmarks of aquaporin-mediated water transport, including an 18-fold increase in the osmotic water permeability of the oolemma, a reduced activation energy, and inhibition of elevated water transport activity by Hg ions.	Water	147-152	aquaporin	Acyrthosiphon pisum	35-41
18983920-8	2009	Taken together, these data suggest that ApAQP1 contributes to the molecular basis of water cycling in the aphid gut.	Water	85-90	aquaporin	Acyrthosiphon pisum	40-46
19200084-7	2009	The water-soluble high molecular weight fraction, which contained myoglobin, was responsible for the high lipoxygenase-like activity and lipid oxidation potential (LOP) in beef loin.	Water	4-9	myoglobin	Gallus gallus	66-75
18926719-5	2009	Herein, one such application has been further demonstrated in the detection and identification of background ions from LC solvents and APPI dopants, including water, acetonitrile, chloroform, methylene chloride, methanol, 2-propanol, hexanes, heptane, cyclohexane, acetone, tetrahydrofuran (THF), 1,4-dioxane, toluene, and anisole.	Water	159-164	amyloid beta precursor protein	Homo sapiens	135-139
18618467-6	2009	Halogen light induced greater monomer elution than LED light immersion in water.	Water	74-79	small integral membrane protein 10 like 2A	Homo sapiens	51-54
20168983-2	2009	Among them, we recently found that Rottlerin inhibits the Nuclear Factor kappaB (NFkappaB), activated by either phorbol esters or H(2)O(2).	Water	130-135	nuclear factor kappa B subunit 1	Homo sapiens	58-79
20168983-2	2009	Among them, we recently found that Rottlerin inhibits the Nuclear Factor kappaB (NFkappaB), activated by either phorbol esters or H(2)O(2).	Water	130-135	nuclear factor kappa B subunit 1	Homo sapiens	81-89
20039816-9	2009	Our study provides evidence pack and stock animals serve as a source of microbial contamination of water along this section of trail.	Water	99-104	TNF superfamily member 10	Homo sapiens	127-132
20131604-8	2009	The prepared Pb(II)-imprinted polymer was shown to be promising for the separation and enrichment of trace Pb(II) from water samples.	Water	119-124	submaxillary gland androgen regulated protein 3B	Homo sapiens	13-19
20131604-8	2009	The prepared Pb(II)-imprinted polymer was shown to be promising for the separation and enrichment of trace Pb(II) from water samples.	Water	119-124	submaxillary gland androgen regulated protein 3B	Homo sapiens	107-113
19662581-3	2009	This work aimed to investigate the in vivo effect of a water extract of lemongrass on pro-inflammatory cytokine (IL-1beta and IL-6) production by macrophages of BALB/c mice.	Water	55-60	interleukin 1 beta	Mus musculus	113-121
20224214-0	2009	Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis.	Water	12-17	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
20224214-4	2009	Among them aquaporin 1 (AQP1) is a predominant water channel expressed in the plasma membranes of human pancreatic ducts.	Water	47-52	aquaporin 1 (Colton blood group)	Homo sapiens	11-22
20224214-4	2009	Among them aquaporin 1 (AQP1) is a predominant water channel expressed in the plasma membranes of human pancreatic ducts.	Water	47-52	aquaporin 1 (Colton blood group)	Homo sapiens	24-28
19012752-8	2009	Finally, these deleterious effects of MGO on STAT3 signaling led to down-regulation of a STAT3 target gene, Bcl-2, and sensitized cellular toxicity induced by H(2)O(2) and etoposide.	Water	159-164	signal transducer and activator of transcription 3	Homo sapiens	45-50
19151543-3	2009	Arginine vasopressin (AVP) is the primary regulator of renal electrolyte-free water reabsorption via AVP-receptor type 2 (V2-R), and inappropriate or excessive AVP secretion independent of serum osmolality frequently causes excessive water retention, which is the etiological basis of hyponatremia.	Water	78-83	arginine vasopressin	Homo sapiens	0-20
19151543-3	2009	Arginine vasopressin (AVP) is the primary regulator of renal electrolyte-free water reabsorption via AVP-receptor type 2 (V2-R), and inappropriate or excessive AVP secretion independent of serum osmolality frequently causes excessive water retention, which is the etiological basis of hyponatremia.	Water	234-239	arginine vasopressin	Homo sapiens	0-20
19267305-8	2009	(2009) describe the chemistry and mutagenicity of a set of DBP mixtures concentrated from five different drinking-water treatment plants.	Water	114-119	D-box binding PAR bZIP transcription factor	Homo sapiens	59-62
19267305-13	2009	Important factors for determining sufficient similarity of DBP mixtures found in this research include disinfectant used; source water characteristics, including the concentrations of bromide and total organic carbon; concentrations and proportions of individual DBPs with known toxicity data on the same endpoint; magnitude of the unidentified fraction of total organic halides; similar toxicity outcomes for whole mixture testing (e.g., mutagenicity); and summary chemical measures such as total trihalomethanes, total haloacetic acids, total haloacetonitriles, and the levels of bromide incorporation in the DBP classes.	Water	129-134	D-box binding PAR bZIP transcription factor	Homo sapiens	59-62
19267309-2	2009	Objective measures of similarities among DBP mixtures would greatly simplify judgments about the risk that may be associated with exposure to DBPs in a given water supply.	Water	158-163	D-box binding PAR bZIP transcription factor	Homo sapiens	41-44
19267309-8	2009	Variations in relative yields among DBP classes were observed with water source type and with whether chlorine or chloramine was used as the disinfectant.	Water	67-72	D-box binding PAR bZIP transcription factor	Homo sapiens	36-39
19662581-3	2009	This work aimed to investigate the in vivo effect of a water extract of lemongrass on pro-inflammatory cytokine (IL-1beta and IL-6) production by macrophages of BALB/c mice.	Water	55-60	interleukin 6	Mus musculus	126-130
19662581-6	2009	Treatment of mice with water extract of lemongrass inhibited macrophages to produce IL-1beta but induced IL-6 production by these cells.	Water	23-28	interleukin 1 beta	Mus musculus	84-92
19662581-6	2009	Treatment of mice with water extract of lemongrass inhibited macrophages to produce IL-1beta but induced IL-6 production by these cells.	Water	23-28	interleukin 6	Mus musculus	105-109
19844828-2	2009	The goal of this work was to investigate the effect of administration of the water extract of clove over a short-term to BALB/c mice on Th1 (IFN-gamma and IL-2) and Th2 (IL-4 and IL-10) cytokine production.	Water	77-82	negative elongation factor complex member C/D, Th1l	Mus musculus	136-139
19844828-2	2009	The goal of this work was to investigate the effect of administration of the water extract of clove over a short-term to BALB/c mice on Th1 (IFN-gamma and IL-2) and Th2 (IL-4 and IL-10) cytokine production.	Water	77-82	interferon gamma	Mus musculus	141-150
19844828-2	2009	The goal of this work was to investigate the effect of administration of the water extract of clove over a short-term to BALB/c mice on Th1 (IFN-gamma and IL-2) and Th2 (IL-4 and IL-10) cytokine production.	Water	77-82	interleukin 10	Mus musculus	179-184
20155626-4	2009	Administration of DSS (2.5%) in drinking water for 7 days to male ICR mice resulted in colitis and elevated expression of inducible nitric oxide synthase (iNOS) and activation of nuclear factor-kappa B (NF-kappaB), a major transcription factor known to upregulate proinflammatory gene expression.	Water	41-46	nitric oxide synthase 2, inducible	Mus musculus	122-153
19054338-6	2009	Constitutive expression of SlTIP2;2 increased the osmotic water permeability of the cell and whole-plant transpiration.	Water	58-63	tonoplast intrinsic protein 2.2	Solanum lycopersicum	27-35
20155626-4	2009	Administration of DSS (2.5%) in drinking water for 7 days to male ICR mice resulted in colitis and elevated expression of inducible nitric oxide synthase (iNOS) and activation of nuclear factor-kappa B (NF-kappaB), a major transcription factor known to upregulate proinflammatory gene expression.	Water	41-46	nitric oxide synthase 2, inducible	Mus musculus	155-159
20155626-4	2009	Administration of DSS (2.5%) in drinking water for 7 days to male ICR mice resulted in colitis and elevated expression of inducible nitric oxide synthase (iNOS) and activation of nuclear factor-kappa B (NF-kappaB), a major transcription factor known to upregulate proinflammatory gene expression.	Water	41-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	179-201
18987488-8	2009	These data suggest that control of water balance or aquaretic drugs might have beneficial effects on splanchnic hemodynamics and portal pressure in advanced liver disease, possibly by stimulating endogenous vasopressin release.	Water	35-40	arginine vasopressin	Rattus norvegicus	207-218
19031361-5	2009	PSA did not show genotoxicity and caused a 50% reduction in DNA damage induced by H2O (EC50:476.47+/-67.46 microM).	Water	82-85	aminopeptidase puromycin sensitive	Rattus norvegicus	0-3
18987216-7	2009	Of the two most highly expressed plasma membrane intrinsic protein (PIP) aquaporins in roots (VvPIP1;1 and VvPIP2;2), only VvPIP2;2 functions as a water channel in Xenopus laevis oocytes.	Water	147-152	aquaporin PIP2-2	Vitis vinifera	123-131
18987216-8	2009	VvPIP1;1 interacts with VvPIP2;2 to induce 3-fold higher water permeability.	Water	57-62	aquaporin-like	Vitis vinifera	0-8
18987216-8	2009	VvPIP1;1 interacts with VvPIP2;2 to induce 3-fold higher water permeability.	Water	57-62	aquaporin PIP2-2	Vitis vinifera	24-32
19042915-1	2009	Aquaporin is a water channel that increases water permeability through membranous structures.	Water	15-20	aquaporin PIP2-7-like	Nicotiana tabacum	0-9
19440390-3	2009	Comparison of over 80 mammalian V2 vasopressin receptor (V2R) orthologs revealed high structural and functional conservation of this key component involved in renal water reabsorption.	Water	165-170	arginine vasopressin receptor 2	Homo sapiens	32-60
19042915-1	2009	Aquaporin is a water channel that increases water permeability through membranous structures.	Water	44-49	aquaporin PIP2-7-like	Nicotiana tabacum	0-9
19042915-9	2009	Thus, increased vacuolar aquaporin activity may accelerate both cell expansion and cell division by increasing water permeability through the vacuolar membrane.	Water	111-116	aquaporin PIP2-7-like	Nicotiana tabacum	25-34
18987216-12	2009	VvPIP1;1 may regulate water transport across roots such that transpirational demand is matched by root water transport capacity.	Water	22-27	aquaporin-like	Vitis vinifera	0-8
18987216-12	2009	VvPIP1;1 may regulate water transport across roots such that transpirational demand is matched by root water transport capacity.	Water	103-108	aquaporin-like	Vitis vinifera	0-8
19440390-6	2009	An increased vasopressin-independent V2R activity can be interpreted as a shift in the set point of the renal-neurohypophysial hormone circuit to realize sufficient water reabsorption already at low hormone levels.	Water	165-170	arginine vasopressin receptor 2	Homo sapiens	37-40
19440390-8	2009	The gain of basal V2R function in several marsupials may contribute to the increased urine concentration abilities and, therefore, provide an advantage to maintain water and electrolyte homeostasis under limited water supply conditions.	Water	164-169	arginine vasopressin receptor 2	Homo sapiens	18-21
19194512-3	2009	After exposure to lethal doses of H(2)O(2), GFP-Tah18 relocalizes to the mitochondria and controls mitochondria integrity and cell death.	Water	34-39	NAPDH-dependent diflavin reductase	Saccharomyces cerevisiae S288C	48-53
19072863-6	2009	TRAMP mice received GTP (0.05% in drinking water) for 4 or 25 weeks.	Water	43-48	tumor necrosis factor receptor superfamily, member 25	Mus musculus	0-5
19200042-1	2009	We examined the effects of air-water and water-sevoflurane interfaces on conformational properties of amyloid-beta peptide (ABP).	Water	41-46	sex hormone binding globulin	Homo sapiens	102-122
19356129-0	2009	Molecular dynamics study of the internal water molecules in vasopressin and oxytocin receptors.	Water	41-46	arginine vasopressin	Homo sapiens	60-71
19356129-1	2009	The role of the internal water molecules in vasopressin and oxytocin receptors has been investigated via molecular dynamics simulations in hydrated membrane model.	Water	25-30	arginine vasopressin	Homo sapiens	44-55
20374732-3	2009	Nephrogenic failure to concentrate urine maximally may be due to a defect in vasopressin-induced water permeability of the distal tubules and collecting ducts, to insufficient buildup of the corticopapillary interstitial osmotic gradient, or to a combination of these two factors.	Water	97-102	arginine vasopressin	Homo sapiens	77-88
20374732-7	2009	Mutations have been identified in the aquaporin-2 gene (AQP2, OMIM 107777)(1), which is located in chromosome region 12q13 and codes for the vasopressin-sensitive water channel.	Water	163-168	arginine vasopressin	Homo sapiens	141-152
19149726-9	2009	The chitosan is modifiable chemically to produce water-soluble low molecular weight polymer which renders insulin able to be processed under mild conditions, and sulphated chitosan which markedly opens the paracellular channels for insulin transport.	Water	49-54	insulin	Homo sapiens	106-113
22573989-2	2009	CAT is present in almost all aerobic living organisms, where it catalyzes the disproportionation of H(2)O(2) into oxygen and water without forming free radicals.	Water	125-130	catalase	Homo sapiens	0-3
19004473-4	2009	DOC and POC concentrations showed flush effects with increasing water discharge and sediment load in the basin-wide scale.	Water	64-69	proopiomelanocortin	Homo sapiens	8-11
19587401-3	2009	The SPI-Water project worked out a number of concrete actions to bridge these gaps in communication by developing and implementing a "science-policy interface", enhancing the use of RTD results in the Water Framework Directive (WFD) implementation.	Water	8-13	chromogranin A	Homo sapiens	4-7
19587401-3	2009	The SPI-Water project worked out a number of concrete actions to bridge these gaps in communication by developing and implementing a "science-policy interface", enhancing the use of RTD results in the Water Framework Directive (WFD) implementation.	Water	201-206	chromogranin A	Homo sapiens	4-7
19759441-8	2009	At pH 9.5 and an initial NO3- concentration of 10 mg L(-1) NO3--N, the concentration of NO2- produced was above 0.1 mg L(-1) NO2--N, the Germany drinking water standard.	Water	154-159	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
19717912-6	2009	In two years out of three, there was a trend for PO-F and pre-veraison (PR-V) water-stressed vines to have the lowest berry soluble solids contents ( degrees Brix), indicating a delay in maturity.	Water	78-83	biogenesis of ribosomes BRX1	Homo sapiens	158-162
19934513-7	2009	Conversely, results for car washing experiments showed that particle diameters up to 6 mum constituted the major part of the total mass generated by both water-efficient and conventional devices.	Water	154-159	latexin	Homo sapiens	87-90
19350817-7	2009	From the results, it can be concluded that the purified SC-2 fraction of water-soluble holothurian glycosides has extremely strong tumor suppressing activity, and the suppression is realized by inducing tumor cells to undergo apoptosis.	Water	73-78	trans-2,3-enoyl-CoA reductase	Homo sapiens	56-60
18957418-4	2008	Abca12-/- mice are born with a thickened epidermis and die shortly after birth, as water rapidly evaporates from their skin.	Water	83-88	ATP-binding cassette, sub-family A (ABC1), member 12	Mus musculus	0-6
19118186-5	2008	TTBK1-Tg mice show significant age-dependent memory impairment as determined by radial arm water maze test, which is associated with enhancement of tau and neurofilament phosphorylation, increased levels of p25 and p35, both activators of cyclin-dependent protein kinase 5 (CDK5), enhanced calpain I activity, and reduced levels of hippocampal NMDA receptor types 2B (NR2B) and D. Enhanced CDK5/p35 complex formation is strongly correlated with dissociation of F-actin from p35, suggesting the inhibitory mechanism of CDK5/p35 complex formation by F-actin.	Water	91-96	tau tubulin kinase 1	Mus musculus	0-5
19074884-13	2008	In a low-selenium population, SOD2-Ala16+ men homozygous for SEPP1-Ala234 are at an increased risk of prostate cancer/aggressive prostate cancer especially if ever-smokers, because they are likely to produce more mitochondrial H(2)O(2) that they cannot remove, thereby promoting prostate tumor cell proliferation and migration.	Water	227-232	selenoprotein P	Homo sapiens	61-66
19053774-1	2008	Vasopressin (AVP) is a hormone that stimulates an increase in water permeability through activation of V2 receptors in the kidney.	Water	62-67	arginine vasopressin	Rattus norvegicus	0-11
19102541-1	2008	Absorption bands of the first electronic transition (X (1)A(1)--&gt;A (1)B(1)) of water (H(2)O) and heavy water (D(2)O) in the liquid state have been directly observed by using a uniquely designed attenuated total reflectance far-ultraviolet (ATR-FUV) spectrometer.	Water	82-87	ATR serine/threonine kinase	Homo sapiens	243-246
18996093-6	2008	ApoE(-/-) mice drank H(2)-water ad libitum from 2 to 6 month old throughout the whole period.	Water	26-31	apolipoprotein E	Mus musculus	0-4
19046074-3	2008	Exposure of SR membranes to water- and lipid-soluble cross-linking reagents revealed a mixture of SERCA1 oligomeric species consisting mainly of dimers and trimers.	Water	28-33	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	98-104
18793755-7	2008	The DeltaG (H2O), the best parameter for the estimation of macromolecule stability, was determined for calmodulin in the absence and presence of Artemisinin and Cyclosporin A.	Water	12-15	calmodulin 1	Homo sapiens	103-113
18793755-8	2008	However, the degree of decrease in DeltaG (H2O) value was as follows: Artemisinin&gt;Cyclosporin A, which means Artemisinin induced more instability in the calmodulin structure.In conclusion, our findings showed a good correlation between the ability of both Artemisinin and Cyclosporin A to block the activation of phosphodiesterase and their ability to bind to the activator and that Artemisinin is a more potent inhibitor of phosphodiesterase compared with Cyclosporin A.	Water	43-46	calmodulin 1	Homo sapiens	156-166
18988797-2	2008	We have previously reported that in normal cholangiocytes a subset of vesicles contain three proteins (ie, the water channel AQP1, the chloride channel CFTR, and the anion exchanger AE2) that account for ion-driven water transport.	Water	111-116	solute carrier family 4 member 2	Rattus norvegicus	182-185
18482860-4	2008	The Co(II) cations present a slightly distorted CoN2O4 octahedral environment, with equatorially coordinated water molecules and axially pyridine N-bound ethylisonicotinate ligands.	Water	109-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18977513-4	2008	Instantaneous air-water exchange fluxes of PCB homologues and HCB were calculated from 22 pairs of air and water samples from Kaohsiung Harbor lagoon.	Water	18-23	pyruvate carboxylase	Homo sapiens	43-46
18977513-4	2008	Instantaneous air-water exchange fluxes of PCB homologues and HCB were calculated from 22 pairs of air and water samples from Kaohsiung Harbor lagoon.	Water	107-112	pyruvate carboxylase	Homo sapiens	43-46
21730676-2	2008	We found that the CdS NP core synthesis was slow and that premature CdS NP cores were formed in the apoferritin cavity when the concentration of ammonia water was low.	Water	153-158	ferritin heavy chain	Equus caballus	100-111
18701343-0	2008	Interaction of water-soluble amino acid Schiff base complexes with bovine serum albumin: fluorescence and circular dichroism studies.	Water	15-20	albumin	Homo sapiens	74-87
18701343-1	2008	Fluorescence spectroscopy in combination with circular dichroism (CD) spectroscopy were used to investigate the interaction of water-soluble amino acid Schiff base complexes, [Zn(L1,2)(phen)] where phen is 1,10-phenanthroline and H2L1,2 is amino acid Schiff base ligands, with bovine serum albumin (BSA) under the physiological conditions in phosphate buffer solution adjusted to pH 7.0.	Water	127-132	albumin	Homo sapiens	284-297
19084912-3	2008	During choleresis, hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.	Water	75-80	aquaporin 8	Homo sapiens	125-129
19084912-6	2008	In addition, biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.	Water	84-89	aquaporin 8	Homo sapiens	119-123
19084912-7	2008	The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.	Water	140-145	aquaporin 8	Homo sapiens	62-66
19057066-1	2008	The title compound, [Co(C(18)H(23)N(10))](BF(4))(2) x H(2)O, is the result of complexing a Co cation (initially in a Co(II) state) with tris[2-(1H-imidazol-2-ylmethyleneamino)ethyl]amine (L), obtained by a condensation process involving imidazole-2-carbaldehyde and tris(2-aminoethyl)amine.	Water	54-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
18988797-2	2008	We have previously reported that in normal cholangiocytes a subset of vesicles contain three proteins (ie, the water channel AQP1, the chloride channel CFTR, and the anion exchanger AE2) that account for ion-driven water transport.	Water	215-220	solute carrier family 4 member 2	Rattus norvegicus	182-185
18674921-4	2008	The stability of At-insulin complex was checked by dialysis against deionized water and Ringer lactate (RL) solution.	Water	78-83	insulin	Homo sapiens	20-27
18674921-5	2008	It has been found that the half-life of At-insulin complex is about approximately 12h, when dialyzed against deionized water and is only 6h, when dialyzed against RL solution having the same composition as blood serum.	Water	119-124	insulin	Homo sapiens	43-50
19053236-6	2008	Initially, water-soluble nanoparticles with carboxylate-terminated monolayers showed thrombin-specific responses in emission intensity (-30% for 1:1 nanoparticle to DNA, +50% for 1:5).	Water	11-16	coagulation factor II, thrombin	Homo sapiens	85-93
18760387-1	2008	Drosophila big brain (bib) encodes for a protein similar to members of the major intrinsic protein family, which includes the water- and ion-conducting aquaporin (AQP) channels.	Water	126-131	big brain	Drosophila melanogaster	22-25
19047156-7	2008	In vivo administration of a water-soluble DNA-PK inhibitor (KU0060648) was shown to maintain luciferase expression in HCT116 xenografts after intratumoral delivery of Ad-RSV-Luc.	Water	28-33	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	42-48
19043239-2	2008	Phase diagrams in the dilute region of the PhyEO(m)/GFA-C(n)/Water systems show the formation of worm-like micelles in some of the surfactant combinations.	Water	61-66	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	52-55
18687780-1	2008	Circulating angiotensin II (ANGII) elicits water intake and activates the hypothalamic-pituitary-adrenal (HPA) axis by stimulating angiotensin type 1 receptors (AT1Rs) within circumventricular organs.	Water	43-48	angiotensinogen	Homo sapiens	12-26
19005303-5	2008	Increased vasopressin secretion due to nonosmotic stimuli leads to decreased electrolyte-free water excretion with resulting water retention and hyponatremia.	Water	94-99	arginine vasopressin	Homo sapiens	10-21
19005303-5	2008	Increased vasopressin secretion due to nonosmotic stimuli leads to decreased electrolyte-free water excretion with resulting water retention and hyponatremia.	Water	125-130	arginine vasopressin	Homo sapiens	10-21
19005303-6	2008	Vasopressin receptor antagonists induce electrolyte-free water diuresis without natriuresis and kaliuresis.	Water	57-62	arginine vasopressin	Homo sapiens	0-11
18653264-7	2008	Transitory exceedance of microbial N-uptake capacity during periods of high water and N flux may therefore provide a mechanism for NO3- leaching.	Water	76-81	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
18687780-1	2008	Circulating angiotensin II (ANGII) elicits water intake and activates the hypothalamic-pituitary-adrenal (HPA) axis by stimulating angiotensin type 1 receptors (AT1Rs) within circumventricular organs.	Water	43-48	angiotensinogen	Homo sapiens	28-33
18197464-2	2008	In particular, the study, performed between April and May 2006, dealt with the surface and ground water monitoring in Ban Nam Khem village and the experimental evaluation of possible drinking treatment alternatives.	Water	98-103	SH3 and cysteine rich domain 3	Homo sapiens	122-125
18975935-3	2008	Ni[(C(6)H(5)PO(3))(H(2)O)] crystallizes in the orthorhombic space group Pmn2(1) and is isostructural with the Mn(II), Fe(II), and Co(II) analogues.	Water	19-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
18719025-9	2008	Levels of aquaporins 1 and 9, which contribute to water uptake in the efferent ducts, were reduced in ERKO mice and partially or fully rescued in AA mice, whereas another water transporter, sodium-hydrogen exchanger-3, was decreased in both ERKO and AA mice.	Water	171-176	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	190-217
19033671-2	2008	In cystic fibrosis (CF), a genetic defect causes a lack of cAMP-regulated CFTR activity, leading to diminished Cl- and water secretion from airway epithelial cells and subsequent mucus plugging, which serves as the focus for infections.	Water	119-124	CF transmembrane conductance regulator	Homo sapiens	74-78
19322975-1	2008	Total body water and tonicity is tightly regulated by renal action of antidiuretic hormone (ADH), reninangiotensin-aldosterone system, norepinephrine and by the thirst mechanism.	Water	11-16	arginine vasopressin	Homo sapiens	70-90
19322975-1	2008	Total body water and tonicity is tightly regulated by renal action of antidiuretic hormone (ADH), reninangiotensin-aldosterone system, norepinephrine and by the thirst mechanism.	Water	11-16	arginine vasopressin	Homo sapiens	92-95
19094059-5	2008	Acute administration of the 5-HT(1A) receptor agonist ipsapirone decreased the rate of tryptophan hydroxylation in striatum, and this effect was significantly larger (+75%) in mice that drank ethanol than in those drinking water.	Water	223-228	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	28-45
19258667-1	2008	It is well known that vasopressin participates in the regulation of the cardiovascular system, water electrolyte balance and many functions of the central nervous system.	Water	95-100	arginine vasopressin	Homo sapiens	22-33
19258667-4	2008	Such a location suggests that vasopressin may participate in the regulation of vascular resistance in cerebral circulation and water homeostasis in the brain.	Water	127-132	arginine vasopressin	Homo sapiens	30-41
19019246-1	2008	BACKGROUND: Sex hormones have a pronounced effect on arginine vasopressin (AVP), and therefore on the diurnal water homeostasis.	Water	110-115	arginine vasopressin	Homo sapiens	62-73
19258663-3	2008	Increased vasopressin secretion stimulates water retention by renal actions, while oxytocin is natriuretic, partly by stimulating cardiac atrial natriuretic peptide (ANP) secretion.	Water	43-48	arginine vasopressin	Rattus norvegicus	10-21
17701287-9	2008	Our data showed that in each combination of genotype and metal ion there were 2-5 different chitinase isoforms significantly responsive to toxic environment when compared with water-treated controls.	Water	176-181	Chi	Hordeum vulgare	92-101
19180911-7	2008	CONCLUSION: Vasopressin may down-regulate the expression of AQP7 mRNA in the endolymphatic sac and induce a decreased absorption of endolymph, which decreases the water permeability in the potassium ions recycle pathway in the organ of Corti and disturbs the circulation of endolymph, resulting in endolymphatic hydrops.	Water	163-168	arginine vasopressin	Rattus norvegicus	12-23
19149939-0	2008	[Influence of recombinant human growth hormone on body fluid compartments and water-sodium retention in severe burn patients].	Water	78-83	growth hormone 1	Homo sapiens	32-46
18980364-4	2008	Gas-phase calculations indicate that electron-withdrawing substituents and trifluoromethyl groups in the ortho position favor deprotonation of HA1 when three water molecules are included in the cluster.	Water	158-163	Rho GTPase activating protein 45	Homo sapiens	143-146
19120974-9	2008	Electron microscopic examination showed that tissue damage during EAU was initiated by non-phagocytic destruction of inner segments by Mac-1(+) mononuclear cells on day 11, followed by phagocytic activity of macrophages against outer segments and RPE cells on day 14.	Water	66-69	integrin alpha M	Mus musculus	135-140
19120974-10	2008	In vitro culturing of normal retinal cells with EAU infiltrates suggested the involvement of TNF-alpha and NO in the tissue damage.	Water	48-51	tumor necrosis factor	Mus musculus	93-102
17602312-1	2008	Asr1 and Asr2 are water stress-inducible genes belonging to the Asr gene family, which transcriptionally regulate a sugar transporter gene, at least in grape.	Water	18-23	abscisic stress-ripening protein 2	Solanum lycopersicum	9-13
20048472-3	2008	Hyponatremia is due to a combination of excessive water or hypotonic fluid intake as well as high levels of arginine vasopressin (or anti diuretic hormone), which limits the ability of the kidney to excrete water.	Water	207-212	arginine vasopressin	Homo sapiens	117-128
18824019-0	2008	A single administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin that produces reduced food and water intake induces long-lasting expression of corticotropin-releasing factor, arginine vasopressin, and proopiomelanocortin in rat brain.	Water	94-99	corticotropin releasing hormone	Rattus norvegicus	142-172
19149939-1	2008	OBJECTIVE: To investigate the influence of recombinant human growth hormone (rhGH) on body fluid compartments and water-sodium retention in severe burn patients.	Water	114-119	growth hormone 1	Homo sapiens	61-75
18977225-4	2008	In contrast to the structure of the human SULT1A3 (hSULT1A3)-dopamine complex previously reported, molecular modeling and mutational analysis revealed that a water molecule plays a critical role in the recognition of the amine group of dopamine by mSULT1D1.	Water	158-163	sulfotransferase family 1D, member 1	Mus musculus	248-256
18515395-8	2008	The magnitude of the Abeta-induced increase in epsilon indicates that Abeta-oligomers affect membranes by inducing lateral heterogeneity in the bilayers, but an increase in the water content of the bilayers was not observed.	Water	177-182	amyloid beta precursor protein	Homo sapiens	21-26
18625240-4	2008	The extrapolated folding rate constants in water at 298 K were 210,000 s(-1) for POB and 27,500 s(-1) for E3BD.	Water	43-48	ER membrane protein complex subunit 3	Homo sapiens	81-84
18818058-2	2008	One biologically relevant example is the enzymatic hydrolysis of DOPC by PLA(2), which results in cleavage of phospholipids molecules into water insoluble lipolytic products, namely oleic acid and lysophospholipid.	Water	139-144	phospholipase A2 group IB	Homo sapiens	73-78
21581161-1	2008	In the title complex, [Co(C(5)H(5)NO(4)P)(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 2-phospho-nato-pyridine N-oxide ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	Water	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
21581161-1	2008	In the title complex, [Co(C(5)H(5)NO(4)P)(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 2-phospho-nato-pyridine N-oxide ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	Water	240-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18641079-3	2008	This finding is demonstrated by increases in the root mean-square deviations of the heavy atoms of lysozyme, in the solvent-accessible surface area of hydrophobic residues, and in the number of hydrogen bonds between lysozyme and water.	Water	230-235	lysozyme	Homo sapiens	217-225
18824919-11	2008	CONCLUSION: In this endotoxic model, dose-targeted arginine vasopressin infusion increased lipopolysaccharide-induced renal dysfunction without affecting renal blood flow and glomerular function, but with particular disruption of aquaporin-2/V2 receptor networking, consecutive decreased salt and water handling ability.	Water	297-302	arginine vasopressin	Rattus norvegicus	60-71
19271488-3	2008	In the present paper, the oxidation of pyrite under the condition of air and water was respectively investigated by the attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) through the designing experiment on the formation of carbon dioxide by the reaction of carbonate in pyrite with sulfuric acid formed by the oxidation of pyrite.	Water	77-82	ATR serine/threonine kinase	Homo sapiens	189-192
19271488-4	2008	The CO2 measurement by in situ ATR indicated that the oxidation rate of pyrite both in the air and in water both reduced by time and the latter reduced more obviously than the former, which indicates that the oxidation rate of pyrite in water is slower than that in the air.	Water	102-107	ATR serine/threonine kinase	Homo sapiens	31-34
19271488-4	2008	The CO2 measurement by in situ ATR indicated that the oxidation rate of pyrite both in the air and in water both reduced by time and the latter reduced more obviously than the former, which indicates that the oxidation rate of pyrite in water is slower than that in the air.	Water	237-242	ATR serine/threonine kinase	Homo sapiens	31-34
18322740-6	2008	A 1-cm water jet was delivered under foot pedal control and endoscopic view at pressures adjusted from 150 to 400 psi.	Water	7-12	BCL2 related protein A1	Homo sapiens	0-3
19178075-2	2008	Anhedonic state was defined by a reduction of preference for sucrose solution over tap water.	Water	87-92	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	83-86
18723516-2	2008	Mutations in the CFTR gene cause cystic fibrosis in which salt, water, and protein transports are defective in various tissues.	Water	64-69	CF transmembrane conductance regulator	Homo sapiens	17-21
18942876-1	2008	The relative stability of alkaline earth metals (M2+ = Mg2+, Ca2+, Sr2+, and Ba2+) and their chloride complexes in aqueous solution is examined through molecular dynamics simulations using a flexible SPC water model with an internally consistent set of metal ion force field parameters.	Water	204-209	proline rich protein gene cluster	Homo sapiens	200-203
18842061-3	2008	Quantum mechanical molecular dynamics (QMD) simulations in the presence of freely dissociable water molecules produced H-bond distributions around deprotonated surface oxygens very similar to those obtained by CMD with nondissociable SPC/E water, thereby confirming that the less computationally intensive CMD simulations provide accurate H-bond information.	Water	94-99	proline rich protein gene cluster	Homo sapiens	234-237
18753266-3	2008	Here our goal was to examine the water and sodium intake in this model under basal conditions and in response to increased ANG II levels.	Water	33-38	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	123-129
18753266-4	2008	Baseline water and NaCl (0.3 M) intakes were significantly elevated in NSE-AT(1A) compared with nontransgenic littermates, and bolus intracerebroventricular injections of ANG II (200 ng in 200 nl) caused further enhanced water intake in NSE-AT(1A).	Water	9-14	angiotensin II receptor, type 1a	Mus musculus	75-80
18753266-7	2008	The results show that brain-selective overexpression of AT(1A) receptors results in enhanced salt appetite and altered water intake.	Water	119-124	angiotensin II receptor, type 1a	Mus musculus	56-61
18753266-8	2008	This model provides a new tool for studying the mechanisms of brain AT(1A)-dependent water and salt consumption.	Water	85-90	angiotensin II receptor, type 1a	Mus musculus	68-73
18619564-0	2008	Molecular dynamics simulations of a lipovitellin-derived amphiphilic beta-sheet homologous to apoB-100 beta-sheets at a hydrophobic decane-water interface.	Water	139-144	apolipoprotein B	Homo sapiens	94-102
19526097-0	2008	Effects of plant water-soluble polysaccharides on the production of immunoglobulins E and G1 by lymphocytes of mice sensitized with ovalbumin.	Water	17-22	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	132-141
19186803-7	2008	The results of coagulation kinetics and Zeta potential studies revealed that Alb acted mainly by charge neutralization as well as adsorption bridge building in water treatment.	Water	160-165	albumin	Homo sapiens	77-80
18543247-0	2008	The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation.	Water	12-17	tumor necrosis factor	Homo sapiens	58-67
18546194-5	2008	The patterned carboxylated domains of 1.0 mm or 0.2 mm diameter were covalently fixed with the anti-CD4 or anti-CD8 antibody by coupling reaction using a water-soluble carbodiimide and hydroxysuccinimide.	Water	154-159	CD4 molecule	Homo sapiens	100-103
18837537-0	2008	New insight into the surface denaturation of proteins: electronic sum frequency generation study of cytochrome c at water interfaces.	Water	116-121	cytochrome c, somatic	Homo sapiens	100-112
18841368-1	2008	Aquaporin1 (AQP1) is a water channel protein which facilitates water flux across cell membranes.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	0-10
18841368-1	2008	Aquaporin1 (AQP1) is a water channel protein which facilitates water flux across cell membranes.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	12-16
18837537-2	2008	The observed electronic spectra of cytochrome c at the air/water interface exhibited a broad feature, which demonstrated coexistence of the nativelike and denatured protein at the interface.	Water	59-64	cytochrome c, somatic	Homo sapiens	35-47
18841885-1	2008	We report on photophysical studies of the interaction between an anesthetic analogue, methyl 2-amino-4,5-dimethoxybenzoate (ADMB), with the human serum albumin (HSA) protein and the normal micelle of n-octyl-beta-D-glucopyranoside (OG) in water solutions.	Water	239-244	albumin	Homo sapiens	146-173
18811140-2	2008	An X-ray cocrystal structure with BACE-1 revealed a novel mode of binding whereby the inhibitor interacts with the catalytic aspartates via bridging water molecules.	Water	149-154	beta-secretase 1	Homo sapiens	34-40
18790491-9	2008	The results demonstrate the applicability of the optimized method for the selective extraction of fluoroquinolones in environmental water samples at the ngL(-1) level.	Water	132-137	leucine rich repeat containing 4C	Homo sapiens	153-159
18827945-4	2008	From acid solution, the crystals of trans-O,O-[Ni(H3L)]Cl.H2O were isolated.	Water	58-61	H3 clustered histone 2	Homo sapiens	50-53
18827945-9	2008	The molecular structures of the complex units found in this structure are analogous to that found in trans-O,O-[Ni(H3L)]Cl.H2O.	Water	123-126	H3 clustered histone 2	Homo sapiens	115-118
18808087-0	2008	Relaxation of (CS2)2(-) to its global minimum mediated by water molecules: photoelectron imaging study.	Water	58-63	chorionic somatomammotropin hormone 2	Homo sapiens	15-18
18808087-6	2008	The first is that the presence of H 2O at the cluster formation stage facilitates the nonadiabatic transitions necessary for reaching the global-minimum dimer-anion equilibrium when starting from the CS 2 (-) + CS 2 asymptote.	Water	34-38	chorionic somatomammotropin hormone 2	Homo sapiens	200-204
18808087-6	2008	The first is that the presence of H 2O at the cluster formation stage facilitates the nonadiabatic transitions necessary for reaching the global-minimum dimer-anion equilibrium when starting from the CS 2 (-) + CS 2 asymptote.	Water	34-38	chorionic somatomammotropin hormone 2	Homo sapiens	211-215
18669624-1	2008	Rat hepatocytes express aquaporin-9 (AQP9), a basolateral channel permeable to water, glycerol, and other small neutral solutes.	Water	79-84	aquaporin 9	Rattus norvegicus	24-35
18812257-0	2008	Synthesis of potent water-soluble tissue transglutaminase inhibitors.	Water	20-25	transglutaminase 2	Homo sapiens	34-57
18983076-6	2008	This NO3 most likely originated from cultivation causing mineralization and nitrification of soil organic nitrogen (SON) in old soil water (precultivation) and is attributed to enhanced microbial activity caused by increased soil wetness beneath cropland (median matric potential -42 m) relative to that beneath natural ecosystems (median -211 m).	Water	133-138	NBL1, DAN family BMP antagonist	Homo sapiens	5-8
18947419-6	2008	Since residual amino groups on dendrimers are associated with cytotoxicity, the unreacted terminal positions of this A3 AR-selective G2.5 dendrimer were present as carboxylate groups, which had the further benefit of increasing water-solubility.	Water	228-233	adenosine A3 receptor	Homo sapiens	117-122
18781714-1	2008	The involvement of protons in the heterogeneous electron transfer between cytochrome c and a gold electrode to which it is attached was studied by comparing the electron transfer rate constants for H2O and D2O solutions.	Water	198-201	cytochrome c, somatic	Homo sapiens	74-86
18669624-1	2008	Rat hepatocytes express aquaporin-9 (AQP9), a basolateral channel permeable to water, glycerol, and other small neutral solutes.	Water	79-84	aquaporin 9	Rattus norvegicus	37-41
18632802-2	2008	In this context, ENaC is controlled by a number of hormones, including vasopressin, which promotes rapid translocation of water and Na+ channels to the plasma membrane and long-term effects on transcription of vasopressin-induced and -reduced transcripts.	Water	122-127	arginine vasopressin	Homo sapiens	71-82
18491415-0	2008	NMR structure of biosynthetic engineered human insulin monomer B31(Lys)-B32(Arg) in water/acetonitrile solution.	Water	84-89	insulin	Homo sapiens	47-54
18387806-6	2008	The Monte Carlo calculated dose-rate constant of the IRA1-(103)Pd source in water was found equal to Lambda=0.669 cGy/h/U with approximate uncertainties of +/-0.1%.	Water	76-81	TBL1X/Y related 1	Homo sapiens	53-57
18788777-2	2008	We produced small (approximately 100-200 nm) ERalpha-siRNA NCs with a water core by incorporating two mixed duplexes of specific ERalpha-siRNAs (ERalpha-mix-siRNA) into NCs.	Water	70-75	estrogen receptor 1	Homo sapiens	45-52
18506810-4	2008	Water cross relaxation with nonpolar side chains of the peptide (Leu2, Ile4, Leu7, and proline residues) are only those expected for bulk solvent.	Water	0-5	beta-1,3-glucuronyltransferase 1	Homo sapiens	77-81
18599641-7	2008	The novel distorted six-coordinated (3N3O) geometry around copper in the Abeta-Cu(2+) complexes include three histidines: glutamic, or/and aspartic acid, and axial water.	Water	164-169	amyloid beta precursor protein	Homo sapiens	73-78
18809654-0	2008	A polymer-type water-soluble peptidoglycan exhibited both Toll-like receptor 2- and NOD2-agonistic activities, resulting in synergistic activation of human monocytic cells.	Water	15-20	toll like receptor 2	Homo sapiens	58-78
18939554-5	2008	Except during the height of summer, PCB activities were up to 30 times higher in the air than in the surface water, but closer to equilibrium in the water column.	Water	109-114	pyruvate carboxylase	Homo sapiens	36-39
18667481-1	2008	Vasopressin regulates water excretion through effects on the renal collecting duct.	Water	22-27	arginine vasopressin	Rattus norvegicus	0-11
18312385-1	2008	Aquaporin-3 (AQP3) is a membrane transport protein that facilitates water and glycerol transport across cell plasma membranes in the basal layer of keratinocytes in normal skin.	Water	68-73	aquaporin 3	Mus musculus	0-11
18312385-1	2008	Aquaporin-3 (AQP3) is a membrane transport protein that facilitates water and glycerol transport across cell plasma membranes in the basal layer of keratinocytes in normal skin.	Water	68-73	aquaporin 3	Mus musculus	13-17
18312385-2	2008	Motivated by a relation between AQP3 expression and skin water content, several companies have marketed cosmetics containing ingredients that increase AQP3 expression.	Water	57-62	aquaporin 3	Mus musculus	32-36
18809654-7	2008	These findings strongly suggested that a polymer-type water-soluble PGN fragment, SEPS, exhibits both TLR2-and NOD2-agonistic activities, which induced the synergistic activation of human monocytic cells.	Water	54-59	toll like receptor 2	Homo sapiens	102-106
18809654-4	2008	The water-soluble PGN polymer, SEPS, exhibited considerably stronger activities to induce pro-inflammatory cytokines than parent PGNs and the PGN monomer, SEPS-M. Short interference RNA targeting TLR2 and NOD2 markedly reduced the activities of SEPS.	Water	4-9	toll like receptor 2	Homo sapiens	196-200
18802082-7	2008	Surprisingly, superior protection against EAU was achieved with alpha-C-GalCer, which induces a strong IFN-gamma but only a weak IL-4 production by iNKT cells, in contrast to the ligands alpha-GalCer (both IFN-gamma and IL-4) and OCH (primarily IL-4).	Water	42-45	interferon gamma	Mus musculus	103-112
18802082-7	2008	Surprisingly, superior protection against EAU was achieved with alpha-C-GalCer, which induces a strong IFN-gamma but only a weak IL-4 production by iNKT cells, in contrast to the ligands alpha-GalCer (both IFN-gamma and IL-4) and OCH (primarily IL-4).	Water	42-45	interferon gamma	Mus musculus	206-215
18665919-6	2008	Platelet exposure to exogenous H(2)O(2) (10 microm) results in activation of Bid and Bax, which was found to be similar to the effect of thrombin.	Water	31-36	BH3 interacting domain death agonist	Homo sapiens	77-80
18665919-6	2008	Platelet exposure to exogenous H(2)O(2) (10 microm) results in activation of Bid and Bax, which was found to be similar to the effect of thrombin.	Water	31-36	BCL2 associated X, apoptosis regulator	Homo sapiens	85-88
18665919-6	2008	Platelet exposure to exogenous H(2)O(2) (10 microm) results in activation of Bid and Bax, which was found to be similar to the effect of thrombin.	Water	31-36	coagulation factor II, thrombin	Homo sapiens	137-145
19385504-4	2008	In normal physiology, CB1 receptors activation is responsible for energy homeostasis, govern emotions and behaviors such as anxiety, fear, appetite, food and water intake.	Water	158-163	cannabinoid receptor 1	Homo sapiens	22-25
18949620-4	2008	Catalase is an alternative mechanism to convert H2O2 to water.	Water	56-61	catalase	Homo sapiens	0-8
18506424-10	2008	Stimulation of NHE1-stimulated sodium ion uptake might also trigger uptake of chloride ions and osmotically obliged water.	Water	116-121	solute carrier family 9 member A1	Homo sapiens	15-19
18974961-10	2008	Catalase, an inhibitor of H(2)O(2), down-regulated the production of IL-8 induced by H(2)O(2).	Water	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
18974961-10	2008	Catalase, an inhibitor of H(2)O(2), down-regulated the production of IL-8 induced by H(2)O(2).	Water	85-90	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
18952773-3	2008	NIP6;1 facilitates the rapid permeation of boric acid across the membrane but is completely impermeable to water.	Water	107-112	NOD26-like intrinsic protein 6;1	Arabidopsis thaliana	0-4
18952773-10	2008	It is proposed that during evolution, NIP5;1 and NIP6;1 were diversified in terms of both the specificity of their expression in plant tissues and their water permeation properties, while maintaining their ability to be induced under low B and their boric acid transport activities.	Water	153-158	NOD26-like intrinsic protein 6;1	Arabidopsis thaliana	49-55
18763765-1	2008	Using the analogue of TpT methylated at the 3"-end N3 position (Tpm3T), we demonstrate that when the oxetane/(6-4) pathway is precluded, water addition occurs at the 3"-end C6 position of the oxetane intermediate to provide its opening.	Water	137-142	limb development membrane protein 1	Homo sapiens	22-25
18778845-3	2008	Thus it was evaluated the influence of some competing ions like silicate and phosphate on As(V) adsorption and the influence of feed water pH in the removal process of As(V) and As(III) species.	Water	133-138	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	168-173
18816387-2	2008	Three days later he estimated hundreds being ill. Untreated tap water from a groundwater source was suspected as the vehicle and chlorination was started 11 May.	Water	64-69	SEC14 like lipid binding 2	Homo sapiens	60-63
18787121-0	2008	Dynamic control of slow water transport by aquaporin 0: implications for hydration and junction stability in the eye lens.	Water	24-29	major intrinsic protein of lens fiber	Homo sapiens	43-54
18787121-1	2008	Aquaporin 0 (AQP0), the most abundant membrane protein in mammalian lens fiber cells, not only serves as the primary water channel in this tissue but also appears to mediate the formation of thin junctions between fiber cells.	Water	117-122	major intrinsic protein of lens fiber	Homo sapiens	0-11
18787121-1	2008	Aquaporin 0 (AQP0), the most abundant membrane protein in mammalian lens fiber cells, not only serves as the primary water channel in this tissue but also appears to mediate the formation of thin junctions between fiber cells.	Water	117-122	major intrinsic protein of lens fiber	Homo sapiens	13-17
18787121-2	2008	AQP0 is remarkably less water permeable than other aquaporins, but the structural basis and biological significance of this low permeability remain uncertain, as does the permeability of the protein in a reported junctional form.	Water	24-29	major intrinsic protein of lens fiber	Homo sapiens	0-4
18787121-3	2008	To address these issues, we performed molecular dynamics (MD) simulations of water transport through membrane-embedded AQP0 in both its (octameric) junctional and (tetrameric) nonjunctional forms.	Water	77-82	major intrinsic protein of lens fiber	Homo sapiens	119-123
18787121-6	2008	Our analysis suggests that the low water permeability of AQP0 may help maintain the mechanical stability of the junction.	Water	35-40	major intrinsic protein of lens fiber	Homo sapiens	57-61
18787121-7	2008	We hypothesize that the structural features leading to low permeability may have evolved in part to allow AQP0 to form junctions that both conduct water and contribute to the organizational structure of the fiber cell tissue and microcirculation within it, as required to maintain transparency of the lens.	Water	147-152	major intrinsic protein of lens fiber	Homo sapiens	106-110
18811940-0	2008	Structural and functional divergence of two fish aquaporin-1 water channels following teleost-specific gene duplication.	Water	61-66	aquaporin 1 (Colton blood group)	Homo sapiens	49-60
18714953-0	2008	An experimental and theoretical study of NSCl decomposition in the presence of trace amounts of water.	Water	96-101	nescient helix-loop-helix 1	Homo sapiens	41-45
18714953-1	2008	An experimental and density functional theory study of the decomposition reaction of NSCl with water molecule(s) into NH 3 and SO 2 is described.	Water	95-100	nescient helix-loop-helix 1	Homo sapiens	85-89
18714953-2	2008	Experiments involving the decomposition of NSCl in the presence of trace amounts of water showed that the formation of both HNSO and SO 2 is faster when the cell and the cell surface are fresh and more likely to be coated in adsorbed water.	Water	84-89	nescient helix-loop-helix 1	Homo sapiens	43-47
18714953-2	2008	Experiments involving the decomposition of NSCl in the presence of trace amounts of water showed that the formation of both HNSO and SO 2 is faster when the cell and the cell surface are fresh and more likely to be coated in adsorbed water.	Water	234-239	nescient helix-loop-helix 1	Homo sapiens	43-47
18714953-4	2008	The barrier for reaction 1 in which NSCl decomposes to form HNSO becomes substantially lower when the explicit hydrogen bonding of water molecules is considered.	Water	131-136	nescient helix-loop-helix 1	Homo sapiens	36-40
18714953-5	2008	The water assisted decomposition reaction mechanism can help account for the experimentally observed conversion of NSCl to produce HNSO in the presence of water.	Water	4-9	nescient helix-loop-helix 1	Homo sapiens	115-119
18714953-5	2008	The water assisted decomposition reaction mechanism can help account for the experimentally observed conversion of NSCl to produce HNSO in the presence of water.	Water	155-160	nescient helix-loop-helix 1	Homo sapiens	115-119
18714953-6	2008	The calculated barrier of reaction 2 (the decomposition of HNSO into NH 3 and SO 2) can also explain the experimental observation of SO 2 bands from the decomposition of NSCl in the presence of water.	Water	194-199	nescient helix-loop-helix 1	Homo sapiens	170-174
18715021-2	2008	For this purpose, the adsorption of lysozyme at the hydrophilic silica-water interface has been chosen as a model system.	Water	71-76	lysozyme	Homo sapiens	36-44
18508040-17	2008	According to the putative water-activation mechanism of G117H BChE, a new histidine/aspartate dyad was introduced into the active center of human AChE at the optimum location for hydrolysis of the OP adduct.	Water	26-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-150
18690732-1	2008	Molecular simulations were performed to study the interactions between a protein (lysozyme, LYZ) and phosphorylcholine-terminated self-assembled monolayers (PC-SAMs) in the presence of explicit water molecules and ions.	Water	194-199	lysozyme	Homo sapiens	82-90
18514640-5	2008	As assessed from the time course of cocaine hydrolyzing activity in plasma, Albu-CocH redistributed into extracellular fluid (16% of estimated total body water) with a t(1/2) of 0.66h and it underwent elimination with a t(1/2) of 8h.	Water	154-159	cochlin	Homo sapiens	81-85
18702475-1	2008	We report studies of the interaction between a proton-transfer dye (1"-hydroxy,2"-acetonaphthone, HAN), with the human serum albumin (HSA) protein and a beta-cyclodextrin derivative (DM-beta-CD) in neutral water solutions.	Water	206-211	albumin	Homo sapiens	119-146
18710217-5	2008	Ti(IV) chelation by 2,3-dihydroxynaphthalene (H2L1) and 2,3-dihydroxynaphthalene-6-sulfonate (H2L2) affords water soluble complexes that protect Ti(IV) from hydrolysis at pH 7.4 and bind to bovine serum albumin (BSA).	Water	108-113	albumin	Homo sapiens	197-210
18714985-6	2008	Our results imply that the hemi- to holo-directed transition in Pb(II)-water complexes is driven by coordination number and not hybridization of the 6s lone-pair orbital or enhanced covalent bonding in the Pb-OH2 bond.	Water	71-76	submaxillary gland androgen regulated protein 3B	Homo sapiens	64-70
18700754-4	2008	The computed values of the exchange coupling between the Co(II) ions across anti-syn carboxylate (1) and syn-syn carboxylate/water (2) bridges are J = -0.060 (1) and -1.90 (2) cm(-1) (with the Hamiltonian being defined as H = -Jsigma(i,j)S(i) x S(j)).	Water	125-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
21200991-1	2008	In the title complex, [Co(C(7)H(4)BrO(2))(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 4-bromo-2-formyl-phenolate ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	Water	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18786401-3	2008	Aquaporin-0 (AQP0) is expressed in the eye lens, where its water permeability is regulated by calmodulin (CaM).	Water	59-64	major intrinsic protein of lens fiber	Homo sapiens	0-11
18786401-3	2008	Aquaporin-0 (AQP0) is expressed in the eye lens, where its water permeability is regulated by calmodulin (CaM).	Water	59-64	major intrinsic protein of lens fiber	Homo sapiens	13-17
18786401-3	2008	Aquaporin-0 (AQP0) is expressed in the eye lens, where its water permeability is regulated by calmodulin (CaM).	Water	59-64	calmodulin 1	Homo sapiens	94-104
21200991-1	2008	In the title complex, [Co(C(7)H(4)BrO(2))(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 4-bromo-2-formyl-phenolate ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	Water	235-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18786401-3	2008	Aquaporin-0 (AQP0) is expressed in the eye lens, where its water permeability is regulated by calmodulin (CaM).	Water	59-64	calmodulin 1	Homo sapiens	106-109
18509662-0	2008	Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains.	Water	21-26	aquaporin 1 (Colton blood group)	Homo sapiens	35-39
18392839-1	2008	Transmembrane water transport is mediated by aquaporins (AQPs), of which AQP1 and AQP4 are expressed in skeletal muscle.	Water	14-19	aquaporin 1 (Colton blood group)	Homo sapiens	73-77
18634864-5	2008	RESULTS: The water extract (taheebo) of Tabebuia avellanedae significantly suppressed the production of prostaglandin (PG) E(2) and nitric oxide (NO), and blocked the mRNA expression of their catalyzing enzymes (cyclooxygenase [COX)-II] and inducible NO synthase [iNOS], respectively), in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.	Water	13-18	nitric oxide synthase 2, inducible	Mus musculus	241-262
18509662-0	2008	Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains.	Water	21-26	amyloid beta precursor protein	Homo sapiens	45-57
18509662-1	2008	Aquaporin-1 (AQP1), a membrane water channel protein, is expressed exclusively in the choroid plexus epithelium in the central nervous system under physiological conditions.	Water	31-36	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
18509662-1	2008	Aquaporin-1 (AQP1), a membrane water channel protein, is expressed exclusively in the choroid plexus epithelium in the central nervous system under physiological conditions.	Water	31-36	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
18509662-2	2008	However, AQP1 expression is enhanced in reactive astrocytes, accumulating in brain lesions of Creutzfeldt-Jakob disease and multiple sclerosis, suggesting a role of AQP1-expressing astrocytes in brain water homeostasis under pathological conditions.	Water	201-206	aquaporin 1 (Colton blood group)	Homo sapiens	9-13
18509662-2	2008	However, AQP1 expression is enhanced in reactive astrocytes, accumulating in brain lesions of Creutzfeldt-Jakob disease and multiple sclerosis, suggesting a role of AQP1-expressing astrocytes in brain water homeostasis under pathological conditions.	Water	201-206	aquaporin 1 (Colton blood group)	Homo sapiens	165-169
18781025-10	2008	The method was applied to the determination of Co(II) in water, biological and standard samples.	Water	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
18596208-1	2008	In the renal collecting duct, vasopressin controls transport of water and solutes via regulation of membrane transporters such as aquaporin-2 (AQP2) and the epithelial urea transporter UT-A.	Water	64-69	arginine vasopressin	Rattus norvegicus	30-41
18775887-4	2008	GALP KO mice are indistinguishable from wild-type (WT) controls in virtually all aspects of growth, sexual development, body weight, food and water consumption, and motor behaviors, when they are allowed unlimited access to standard rodent chow.	Water	142-147	galanin-like peptide	Mus musculus	0-4
18781902-1	2008	Arginine vasopressin is a naturally occurring peptide with established physiological functions acting as a vasoconstrictor through V1 receptors or an aquagenic agent allowing free water retention through V2 receptors in the kidney.	Water	180-185	arginine vasopressin	Homo sapiens	9-20
18801241-1	2008	Water quality estimation in fresh and marine water systems with in situ above-water spectroscopy requires measurement of the volume reflectance (rhov) of water bodies.	Water	0-5	ras homolog family member V	Homo sapiens	145-149
18801241-1	2008	Water quality estimation in fresh and marine water systems with in situ above-water spectroscopy requires measurement of the volume reflectance (rhov) of water bodies.	Water	45-50	ras homolog family member V	Homo sapiens	145-149
18691893-0	2008	Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis.	Water	45-50	CF transmembrane conductance regulator	Homo sapiens	15-19
18691893-2	2008	Fifty-eight CFTR(inh)-172 analogs were synthesized to identify CFTR inhibitors with improved water solubility, exploring modifications in its two phenyl rings, thiazolidinone core, and core-phenyl connectors.	Water	93-98	CF transmembrane conductance regulator	Homo sapiens	63-67
18534997-5	2008	Cycloheximide solution was used for ODA against tap water.	Water	52-57	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	48-51
18483148-8	2008	The capacity of fish to sequester SHBG ligands from water is similar between sexes, independent of size, and characterized by a wide dynamic range.	Water	52-57	sex hormone-binding globulin	Danio rerio	34-38
18483148-3	2008	Although the uptake of steroids by fish from water has been reported to correlate with their affinity for SHBG, it is not known how this occurs.	Water	45-50	sex hormone-binding globulin	Danio rerio	106-110
18985840-1	2008	The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a disorder of sodium and water balance characterized by hypotonic hyponatremia and impaired water excretion in the absence of renal insufficiency , adrenal insufficiency or any recognized stimulus for the antidiuretic hormone (ADH).	Water	97-102	arginine vasopressin	Homo sapiens	30-50
18558402-8	2008	The water-soluble secreted form of PPG at a concentration of 1 microg glycan/ml seems to be a potent inducer of ROS and IL-10 and to a lesser extent of IFN-gamma and IL-12.	Water	4-9	interferon gamma	Homo sapiens	152-161
18985840-1	2008	The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a disorder of sodium and water balance characterized by hypotonic hyponatremia and impaired water excretion in the absence of renal insufficiency , adrenal insufficiency or any recognized stimulus for the antidiuretic hormone (ADH).	Water	97-102	arginine vasopressin	Homo sapiens	64-67
18985840-2	2008	An inappropriate increase in ADH release of any cause produces hyponatremia by interfering with urinary dilution, thereby preventing the excretion of ingested water.	Water	159-164	arginine vasopressin	Homo sapiens	29-32
18548108-3	2008	AQP3-knockout mice have reduced stratum corneum water content and elasticity compared with wild-type mice, as well as impaired wound healing and epidermal biosynthesis.	Water	48-53	aquaporin 3	Mus musculus	0-4
18548108-1	2008	Aquaporin-3 (AQP3) is a membrane transporter of water and glycerol expressed in plasma membranes in the basal layer keratinocytes of epidermis in normal skin.	Water	48-53	aquaporin 3	Mus musculus	0-11
18803714-8	2008	The pretreatments from OA or UA significantly attenuated subsequent H(2)O(2)- or MPP(+)-induced release of IL-6 and TNF-alpha (P &lt; 0.05).	Water	68-73	interleukin 6	Rattus norvegicus	107-111
18803714-8	2008	The pretreatments from OA or UA significantly attenuated subsequent H(2)O(2)- or MPP(+)-induced release of IL-6 and TNF-alpha (P &lt; 0.05).	Water	68-73	tumor necrosis factor	Rattus norvegicus	116-125
18548108-1	2008	Aquaporin-3 (AQP3) is a membrane transporter of water and glycerol expressed in plasma membranes in the basal layer keratinocytes of epidermis in normal skin.	Water	48-53	aquaporin 3	Mus musculus	13-17
18667360-3	2008	In Alzheimer"s disease, the conversion of the amyloid-beta peptide (Abeta) from a physiological water-soluble monomeric form into neurotoxic oligomeric and fibrillar forms rich in stable beta-sheet conformations is an important event.	Water	96-101	amyloid beta precursor protein	Homo sapiens	68-73
18512758-2	2008	The diffusion of water in white matter tracts of Npc1(-/-) mice at this young age was already abnormal, exhibiting decreased anisotropy, as quantified by fractional anisotropy (FA), compared with their wild-type littermates, the controls.	Water	17-22	NPC intracellular cholesterol transporter 1	Mus musculus	49-53
18838842-6	2008	Pre-exercise hyperhydration increased body water by 16.1+/-2.2 ml.kg body mass(-1).	Water	43-48	adhesion G protein-coupled receptor V1	Homo sapiens	74-81
18431594-0	2008	Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.	Water	66-71	arginine vasopressin	Homo sapiens	38-49
18369660-15	2008	The observations disclose a role of PKB/SGK-dependent GSK3 activity in the regulation of steroid hormone release, renal water and electrolyte excretion and blood pressure control.	Water	120-125	thymoma viral proto-oncogene 1	Mus musculus	36-39
18431594-8	2008	This review focuses on our recent increase in understanding of the molecular mechanisms underlying AVP-regulated renal water transport in both health and disease.	Water	119-124	arginine vasopressin	Homo sapiens	99-102
18637679-1	2008	A new chemosensor RF1 that combines a ferrocene unit and a rhodamine block via the linkage of a carbohydrazone binding unit was designed and prepared for the highly selective detection of Hg (2+) in natural water.	Water	207-212	mitochondrial translation release factor 1	Homo sapiens	18-21
18688536-3	2008	Quantitative polarization analysis of the measured SHG data indicated that the average orientation of the interfacial water molecules changed only slightly around 40 degrees with the increase of the bulk concentration of the three sodium halides, namely NaF, NaCl and NaBr, from that of the neat air/water interface.	Water	118-123	C-X-C motif chemokine ligand 8	Homo sapiens	254-257
18688536-4	2008	The observed significant SHG signal increase with the bulk salt concentration is attributed to the overall increase of the thickness of the interfacial water molecular layer, following the order of NaBr &gt; NaCl approximately NaF.	Water	152-157	C-X-C motif chemokine ligand 8	Homo sapiens	227-230
18562316-6	2008	An analysis of the available high resolution structures of TIM dimers revealed that this cluster forms a cavity that possesses an elaborate conserved network of buried water molecules that bridge the two subunits.	Water	168-173	triosephosphate isomerase 1	Homo sapiens	59-62
19044806-0	2008	Water in hydrated orthorhombic lysozyme crystal: Insight from atomistic simulations.	Water	0-5	lysozyme	Homo sapiens	31-39
19044806-1	2008	Biologically important water in orthorhombic lysozyme crystal is investigated using atomistic simulations.	Water	23-28	lysozyme	Homo sapiens	45-53
19044806-2	2008	A distinct hydration shell surrounding lysozyme molecules is found from the number distribution of water molecules.	Water	99-104	lysozyme	Homo sapiens	39-47
19044806-4	2008	Adsorption of water in the lysozyme crystal shows type-IV behavior.	Water	14-19	lysozyme	Homo sapiens	27-35
18637679-7	2008	The obvious and characteristic color change of the titration solution from colorless to pink upon the addition of Hg (2+) demonstrates that RF1 can be used for "naked-eye" detection of Hg (2+) in water.	Water	196-201	mitochondrial translation release factor 1	Homo sapiens	140-143
18767656-8	2008	Enhanced DBP-FP is especially important as these wetlands contribute to a watershed that is a drinking water source for more than 23 million people.	Water	74-79	D-box binding PAR bZIP transcription factor	Homo sapiens	9-12
18767670-0	2008	Field deployment of polyethylene devices to measure PCB concentrations in pore water of contaminated sediment.	Water	79-84	pyruvate carboxylase	Homo sapiens	52-55
18767670-6	2008	Pore water concentrations decreased up to 60% within 18 months after activated carbon amendment, as compared to a mechanical-mixed control plot Results of this study illustrate PEDs provide an inexpensive, in situ method to measure total PCB contamination in sediment pore water using a small set of PRCs.	Water	5-10	pyruvate carboxylase	Homo sapiens	238-241
19128258-8	2008	Transepidermal water loss, water content, and corneal thickness were significantly less in bFGF-treated than in non-bFGF-treated scars (p&lt;0.01).	Water	15-20	fibroblast growth factor 2	Homo sapiens	91-95
18767670-6	2008	Pore water concentrations decreased up to 60% within 18 months after activated carbon amendment, as compared to a mechanical-mixed control plot Results of this study illustrate PEDs provide an inexpensive, in situ method to measure total PCB contamination in sediment pore water using a small set of PRCs.	Water	273-278	pyruvate carboxylase	Homo sapiens	238-241
18616315-1	2008	We report observations of the changes in the surface structure of lysozyme adsorbed at the air-water interface produced by the chemical denaturant guanidinium chloride.	Water	95-100	lysozyme	Homo sapiens	66-74
19128258-8	2008	Transepidermal water loss, water content, and corneal thickness were significantly less in bFGF-treated than in non-bFGF-treated scars (p&lt;0.01).	Water	27-32	fibroblast growth factor 2	Homo sapiens	91-95
18678705-1	2008	Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane and its vasopressin and protein kinase A (PKA)-dependent regulation in renal collecting ducts is critical for body water homeostasis.	Water	15-20	arginine vasopressin	Homo sapiens	79-90
18616315-0	2008	Effect of the air-water interface on the structure of lysozyme in the presence of guanidinium chloride.	Water	18-23	lysozyme	Homo sapiens	54-62
18648693-1	2008	In nature the four electron reduction of O2 to H2O is carried out by Cytochrome c oxidase (CcO) and the multicopper oxidases (MCOs).	Water	47-50	cytochrome c, somatic	Homo sapiens	69-81
18633526-0	2008	Reagent switchable stereoselective beta(1,2) mannoside mannosylation: OH-2 of mannose is a privileged acceptor.	Water	70-74	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	35-43
18627199-4	2008	Confocal microscopy indicated that the human serum albumin (HSA) preferentially adsorbed at the oil/water interface, even in the presence of another protein (glucose oxidase).	Water	100-105	albumin	Homo sapiens	45-58
18578504-1	2008	Phosphorylation plays vital roles in the regulation and function of the V2 vasopressin receptor (V2R), a G protein-coupled receptor (GPCR) that is responsible for maintaining water homeostasis in the kidney.	Water	175-180	arginine vasopressin receptor 2	Homo sapiens	72-100
18689950-0	2008	Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyrate with water-soluble tetrazolium salt.	Water	110-115	angiotensin I converting enzyme	Homo sapiens	9-40
18689950-2	2008	In this study, an ACE-inhibiting assay was improved by the use of a water-soluble tetrazolium salt, 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate sodium salt (WST-1), for the detection of 3-hydroxybutyrate, derived from 3HB-GGG.	Water	68-73	angiotensin I converting enzyme	Homo sapiens	18-21
18327703-12	2008	ATV increased myocardial levels of Ser-473 phosphorylated Akt in the water + sugar and DC groups, but not in the CC group.	Water	69-74	AKT serine/threonine kinase 1	Rattus norvegicus	58-61
18441032-0	2008	Side-chain dynamics are critical for water permeation through aquaporin-1.	Water	37-42	aquaporin 1	Bos taurus	62-73
18441032-1	2008	Molecular dynamics simulations of aquaporin-1 embedded in a solvated lipid bilayer were carried out to investigate the mechanism of water permeation.	Water	132-137	aquaporin 1	Bos taurus	34-45
18508070-1	2008	The real-time changes in viscoelasticity of adsorbed poly(L-lysine) (PLL) and adsorbed histone (lysine rich fraction) due to cross-linking by glutaraldehyde and corresponding release of associated water were investigated using a quartz crystal microbalance with dissipation monitoring (QCM-D) and attenuated total reflection Fourier transform infrared spectroscopy (ATR/FTIR).	Water	197-202	ATR serine/threonine kinase	Homo sapiens	366-369
18602135-6	2008	For example, in the standing of anaerobic water samples, the As(III) concentration immediately began decreasing whereas dead time was observed in the removal of As(V).	Water	42-47	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	161-166
18603467-6	2008	This review paper summarizes the impact of individual material compositions, water content, hydrophobicity and electrostatic attraction on the adsorption behavior of the protein albumin.	Water	77-82	albumin	Homo sapiens	178-185
18493110-10	2008	The present study indicates that hypothalamic space-occupying lesions causes central diabetes insipidus and hypodipsia, and that sporadic and paradoxical release of AVP, enhanced renal concentrating ability and reduced drinking behavior may possess body water minimally in the hypernatremic subjects without water deficit.	Water	254-259	arginine vasopressin	Homo sapiens	165-168
18756103-3	2008	Both the n-hexane and water fractions from NE (MEH and MW, respectively) inhibited the production of nitrite and IL-6 in RAW 264.7 cells.	Water	22-27	epoxide hydrolase 1, microsomal	Mus musculus	47-50
18481120-4	2008	In the present study, the stability of various C-terminal fragments of the ARP p18(INK4c) was investigated by all-atomic 450 ns molecular dynamics (MD) simulations in explicit water solvent.	Water	176-181	cyclin dependent kinase inhibitor 2C	Homo sapiens	79-82
18700282-4	2008	Our results show that water maze training induces a rapid recruitment of NMDAR subunits (NR1, NR2A, NR2B) and PSD-95 to synaptic lipid rafts and decrease in the post-synaptic density plus an increase of NR2B phosphorylation at tyrosine 1472 in the rat insular cortex.	Water	22-27	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	94-98
18641360-2	2008	The Th2 cytokines IL-13 and IL-4 are produced during allergic responses and cause increases in airway epithelial cell mucus and electrolyte and water secretion into the airway surface liquid (ASL).	Water	144-149	interleukin 13	Mus musculus	18-23
18756103-3	2008	Both the n-hexane and water fractions from NE (MEH and MW, respectively) inhibited the production of nitrite and IL-6 in RAW 264.7 cells.	Water	22-27	interleukin 6	Mus musculus	113-117
18508773-0	2008	Phosphorylation determines the calmodulin-mediated Ca2+ response and water permeability of AQP0.	Water	69-74	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	91-95
18556058-3	2008	Environmentally induced alterations in p53 protein expression, in relation to leukemia, have been reported in various mollusc species inhabiting polluted water, suggesting that p53 proteins can also be used as a marker for environmental research.	Water	154-159	cellular tumor antigen p53	Crassostrea gigas	39-42
18556058-3	2008	Environmentally induced alterations in p53 protein expression, in relation to leukemia, have been reported in various mollusc species inhabiting polluted water, suggesting that p53 proteins can also be used as a marker for environmental research.	Water	154-159	cellular tumor antigen p53	Crassostrea gigas	177-180
18563405-2	2008	To test the hypothesis that human cystic fibrosis transmembrane conductance regulator (hCFTR) can directly mediate the efflux of the oxalate anion, we compared cAMP-stimulated 36Cl-, 14C-oxalate, and 35SO(4)2- efflux from Xenopus oocytes expressing hCFTR with water-injected control oocytes.	Water	260-265	CF transmembrane conductance regulator	Homo sapiens	34-85
18563405-2	2008	To test the hypothesis that human cystic fibrosis transmembrane conductance regulator (hCFTR) can directly mediate the efflux of the oxalate anion, we compared cAMP-stimulated 36Cl-, 14C-oxalate, and 35SO(4)2- efflux from Xenopus oocytes expressing hCFTR with water-injected control oocytes.	Water	260-265	CF transmembrane conductance regulator	Homo sapiens	87-92
18723490-0	2008	Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.	Water	44-49	tumor protein p53	Homo sapiens	33-36
18456371-4	2008	This same prohormone is also the precursor of MCH, widely studied in relation to food and water intake, and NGE, of which little is known.	Water	90-95	pro-melanin concentrating hormone	Homo sapiens	46-49
20641953-3	2004	Angiotensin II also stimulates the production of aldosterone from the adrenal glands, which promotes retention of sodium and water.	Water	125-130	angiotensinogen	Homo sapiens	0-14
18508773-1	2008	In Xenopus oocytes, the water permeability of AQP0 (P(f)) increases with removal of external calcium, an effect that is mediated by cytoplasmic calmodulin (CaM) bound to the C terminus of AQP0.	Water	24-29	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	46-50
18508773-1	2008	In Xenopus oocytes, the water permeability of AQP0 (P(f)) increases with removal of external calcium, an effect that is mediated by cytoplasmic calmodulin (CaM) bound to the C terminus of AQP0.	Water	24-29	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	188-192
18582019-2	2008	ApoE-NT in a water/alcohol mixture was also shown to experience conformational changes exhibiting similarities with those induced upon lipid binding.	Water	13-18	apolipoprotein E	Homo sapiens	0-4
18555566-0	2008	Adjuvant effect of water-soluble polysaccharide (PAP) from the mycelium of Polyporus albicans on the immune responses to ovalbumin in mice.	Water	19-24	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	121-130
18582019-3	2008	The structure and dynamics of apoE-NT have been here investigated by analyzing 40 ns and 60 ns molecular dynamics simulations performed in water and in a water/propanol mixture, respectively.	Water	139-144	apolipoprotein E	Homo sapiens	30-34
18582019-3	2008	The structure and dynamics of apoE-NT have been here investigated by analyzing 40 ns and 60 ns molecular dynamics simulations performed in water and in a water/propanol mixture, respectively.	Water	154-159	apolipoprotein E	Homo sapiens	30-34
18582019-4	2008	The overall structural properties show alterations of the tertiary structure of apoE-NT in the water/alcohol system in agreement with those observed experimentally.	Water	95-100	apolipoprotein E	Homo sapiens	80-84
18642438-0	2008	Retraction notice to "Determination of Co(II) in water and soil samples using spectrophotometry coupled with preconcentration on 4-amino methyl pyridine anchored silica gel column" [J.	Water	49-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
18647045-0	2008	Microcalorimetric study of thermal unfolding of lysozyme in water/glycerol mixtures: an analysis by solvent exchange model.	Water	60-65	lysozyme	Homo sapiens	48-56
18647045-2	2008	In particular, the thermal denaturation of a model system formed by lysozyme dissolved in water in the presence of the stabilizing cosolvent glycerol has been considered.	Water	90-95	lysozyme	Homo sapiens	68-76
18553943-1	2008	A water sensor for a nonaqueous solvent was fabricated using poly(1,5-diaminonapthalene (DAN) nanofibers, which were prepared through a catalytic chemical polymerization of the DAN monomer using Fe(III) salt as the catalyst.	Water	2-7	NBL1, DAN family BMP antagonist	Homo sapiens	89-92
18553943-1	2008	A water sensor for a nonaqueous solvent was fabricated using poly(1,5-diaminonapthalene (DAN) nanofibers, which were prepared through a catalytic chemical polymerization of the DAN monomer using Fe(III) salt as the catalyst.	Water	2-7	NBL1, DAN family BMP antagonist	Homo sapiens	177-180
18553943-4	2008	The electrochemical activity of poly(1,5-DAN) nanofibers was utilized for water sensing.	Water	74-79	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
18553943-5	2008	The fabrication of water sensor was followed by placing one drop (about 2 microL) of 0.01% poly(1,5-DAN) nanofibers solution in the gap between two split gold electrodes (PBSA) and completely dried.	Water	19-24	NBL1, DAN family BMP antagonist	Homo sapiens	100-103
18572937-8	2008	Chaotropic agents (e.g., salts, trehalose, urea, temperature) that disrupt water structure and the ability of water to mediate intermolecular hydrogen bonding also specifically expanded PIP 2 monolayers.	Water	110-115	prolactin induced protein	Homo sapiens	186-189
18572937-9	2008	These results suggest a combination of water-mediated hydrogen bonding and headgroup repulsion in determining the organization of PIP 2, and may contribute to an explanation for the unique functionality of PIP 2 compared to other anionic phospholipids.	Water	39-44	prolactin induced protein	Homo sapiens	130-133
18572937-9	2008	These results suggest a combination of water-mediated hydrogen bonding and headgroup repulsion in determining the organization of PIP 2, and may contribute to an explanation for the unique functionality of PIP 2 compared to other anionic phospholipids.	Water	39-44	prolactin induced protein	Homo sapiens	206-209
18624539-5	2008	125, 074510 (2006) for a review] it has been suggested that, when coupled to a simple Lennard-Jones model for various small nonpolar solute molecules, the most common models of water (e.g., SPC/E and TIP4P) fail to reproduce quantitatively the solubility of small nonpolar solute molecules in water due in part to failing to account for polarization of the solute molecule.	Water	177-182	proline rich protein gene cluster	Homo sapiens	190-193
18585272-1	2008	In this study the interaction between gallic acid and human serum albumin (HSA) in AOT/isooctane/water microemulsions was characterized for the first time using fluorescence quenching technique in combination with UV absorption spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, circular dichroism (CD) spectroscopy and dynamic light scattering (DLS) technique.	Water	97-102	albumin	Homo sapiens	60-73
18529009-0	2008	Water-soluble tripeptide Abeta (9-11) forms amyloid-like fibrils and exhibits neurotoxicity.	Water	0-5	histocompatibility 2, class II antigen A, beta 1	Mus musculus	25-30
18543871-0	2008	Solvent interactions with [Val(5)]angiotensin II in ethanol-water.	Water	60-65	angiotensinogen	Homo sapiens	34-48
18529009-1	2008	A water-soluble, hydrophilic tripeptide GYE, having sequence identity with the N-terminal segment of amyloid peptides Abeta(9-11), upon self-association exhibits amyloid-like fibrils and significant neurotoxicity towards the Neuro2A cell line.	Water	2-7	histocompatibility 2, class II antigen A, beta 1	Mus musculus	118-123
18614833-2	2008	Potentiometric measurements showed that the Galvani potential difference of the oil/water (O/W) interface played a crucial role in the spontaneous extraction of Cyt c with bis(2-ethylhexyl)sulfosuccinate (AOT).	Water	84-89	cytochrome c, somatic	Homo sapiens	161-166
18463227-11	2008	Knockdown of PKC-alpha using antisense oligonucleotides also slightly protected (~22%) against H(2)O(2).	Water	95-100	protein kinase C alpha	Homo sapiens	13-22
18417545-2	2008	We investigated the mechanisms of AVP-induced cell swelling in isolated, perfused rat inner medullary collecting ducts (IMCDs) using quantitative video microscopy and fluorescence-based measurements of transepithelial water transport.	Water	218-223	arginine vasopressin	Rattus norvegicus	34-37
18417545-4	2008	When a transepithelial osmolality gradient was imposed by addition of NaCl to the bath, AVP significantly increased both water flux and cell height.	Water	121-126	arginine vasopressin	Rattus norvegicus	88-91
18417545-5	2008	When the osmolality gradient was imposed by addition of mannitol, AVP increased water flux but not cell height, suggesting that AVP-induced cell swelling requires a NaCl gradient and is not merely dependent on the associated water flux.	Water	80-85	arginine vasopressin	Rattus norvegicus	66-69
18417545-5	2008	When the osmolality gradient was imposed by addition of mannitol, AVP increased water flux but not cell height, suggesting that AVP-induced cell swelling requires a NaCl gradient and is not merely dependent on the associated water flux.	Water	225-230	arginine vasopressin	Rattus norvegicus	66-69
18417545-5	2008	When the osmolality gradient was imposed by addition of mannitol, AVP increased water flux but not cell height, suggesting that AVP-induced cell swelling requires a NaCl gradient and is not merely dependent on the associated water flux.	Water	225-230	arginine vasopressin	Rattus norvegicus	128-131
18417545-11	2008	We conclude that the AVP-induced cell height increase is dependent on basolateral solute uptake via NKCC1 and changes in actin organization via myosin II, but is not dependent specifically on increased apical water entry.	Water	209-214	arginine vasopressin	Rattus norvegicus	21-24
18480304-5	2008	RESULTS: Besides reducing caspase-9 activation and intracellular ROS levels induced by H(2)O(2), treatment of T beta(4) could also increase cell viability and stimulate the expression of manganese superoxide dismutase (SOD) and copper/zinc SOD.	Water	87-92	thymosin beta 4 X-linked	Homo sapiens	110-119
18272252-2	2008	The icv(p) ANG II induced a four-fold higher ingestion of 0.15M NaHCO(3) than of other mineral solutions at palatable concentrations (0.15M NaCl, 0.05 mM CaCl(2) and 0.01 M KCl) in a five-bottle test with water available in a fifth bottle; water intake was not consistently high in this test.	Water	205-210	angiotensinogen	Rattus norvegicus	11-17
18457654-1	2008	Cytochrome c oxidase is a membrane-bound enzyme, which catalyses the one-electron oxidation of four molecules of cytochrome c and the four-electron reduction of O(2) to water.	Water	169-174	cytochrome c, somatic	Homo sapiens	0-12
18457654-1	2008	Cytochrome c oxidase is a membrane-bound enzyme, which catalyses the one-electron oxidation of four molecules of cytochrome c and the four-electron reduction of O(2) to water.	Water	169-174	cytochrome c, somatic	Homo sapiens	113-125
18572963-4	2008	Arabinoxylan samples with an Ara/Xyl ratio of 0.30 and below agglomerated in a water solution as seen by changes in light scattering.	Water	79-84	ATP binding cassette subfamily C member 6	Homo sapiens	0-3
18434255-0	2008	Dobutamine inhibits vasopressin-mediated water transport across toad bladder epithelium.	Water	41-46	arginine vasopressin	Homo sapiens	20-31
18434616-8	2008	Suppression of arginine vasopressin release by high water intake is protective.	Water	52-57	arginine vasopressin	Rattus norvegicus	24-35
18434255-9	2008	Taken together, the results of this study demonstrate that dobutamine inhibits vasopressin-stimulated water transport in toad bladders through a mechanism mediated by the stimulation of alpha(2)-adrenoceptors, thus suggesting that such a drug may exert a direct cellular effect on membrane permeability to water in transporting epithelia.	Water	102-107	arginine vasopressin	Homo sapiens	79-90
18434255-9	2008	Taken together, the results of this study demonstrate that dobutamine inhibits vasopressin-stimulated water transport in toad bladders through a mechanism mediated by the stimulation of alpha(2)-adrenoceptors, thus suggesting that such a drug may exert a direct cellular effect on membrane permeability to water in transporting epithelia.	Water	306-311	arginine vasopressin	Homo sapiens	79-90
18434255-5	2008	These results demonstrate that this catecholamine may inhibit vasopressin-stimulated water transport at a site prior to cAMP formation.	Water	85-90	arginine vasopressin	Homo sapiens	62-73
18501347-6	2008	The membrane water permeability (P(w)) of Delta213-AQP0 expressing oocytes (14+/-1 microm/s) was significantly lower than those expressing WT-AQP0 (25+/-3 microm/s).	Water	13-18	major intrinsic protein of lens fiber	Homo sapiens	50-55
18023931-4	2008	QSAR model derived from Hansch analysis demonstrated that COX-2 inhibitory activity is correlated with sum of atomic polarizability (Apol), number of hydrogen-bond donor groups (HBD), energy of the highest occupied molecular orbital (HOMO), desolvation free energy for water (F(H(2)O)) and fraction of areas of molecular shadow in the XY and ZX planes over area of enclosing rectangle (Sxyf and Sxzf) with r ranges 0.870-0.904.	Water	269-274	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-63
18501347-6	2008	The membrane water permeability (P(w)) of Delta213-AQP0 expressing oocytes (14+/-1 microm/s) was significantly lower than those expressing WT-AQP0 (25+/-3 microm/s).	Water	13-18	major intrinsic protein of lens fiber	Homo sapiens	51-55
17957381-1	2008	It has been the general consensus that cAMP-mediated PKA-dependent phosphorylation of aquaporin-2 is the primary mechanism of vasopressin to regulate osmotic water permeability in kidney collecting duct.	Water	158-163	cathelicidin antimicrobial peptide	Homo sapiens	39-43
18521188-4	2008	Using a mouse model of episodic inflammatory bowel disease by repeated administration of dextran sulfate sodium in the drinking water, we show that Aag-mediated DNA repair prevents colonic epithelial damage and reduces the severity of dextran sulfate sodium-induced colon tumorigenesis.	Water	128-133	N-methylpurine-DNA glycosylase	Mus musculus	148-151
18549677-0	2008	Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro.	Water	51-56	negative elongation factor complex member C/D, Th1l	Mus musculus	74-77
17957381-1	2008	It has been the general consensus that cAMP-mediated PKA-dependent phosphorylation of aquaporin-2 is the primary mechanism of vasopressin to regulate osmotic water permeability in kidney collecting duct.	Water	158-163	arginine vasopressin	Homo sapiens	126-137
18407938-0	2008	Direct observation of conformational folding coupled with disulphide rearrangement by using a water-soluble selenoxide reagent--a case of oxidative regeneration of ribonuclease A under weakly basic conditions.	Water	94-99	ribonuclease pancreatic	Bos taurus	164-178
18562499-5	2008	Recovery from activation was strongly dependent on PIP(2) acyl chain length, with channels exposed to water-soluble diC4 and diC8 showing much faster recovery than those exposed to PIP(2) (diC16).	Water	102-107	prolactin induced protein	Homo sapiens	51-54
18436890-2	2008	Experimental studies suggest that astrocytic endothelin-1 (ET-1) has deleterious effects on water homeostasis, cerebral edema, and blood brain barrier (BBB) integrity, which contribute to more severe ischemic brain injury.	Water	92-97	endothelin 1	Homo sapiens	45-57
17957381-7	2008	These observations suggest that activation of Epac by cAMP may also contribute to the action of vasopressin in regulating osmotic water permeability.	Water	130-135	cathelicidin antimicrobial peptide	Homo sapiens	54-58
17957381-7	2008	These observations suggest that activation of Epac by cAMP may also contribute to the action of vasopressin in regulating osmotic water permeability.	Water	130-135	arginine vasopressin	Homo sapiens	96-107
18196268-3	2008	In this paper, we identified the binding site for tetraethylammonium (TEA) of the membrane water channel aquaporin-1 by a combined molecular docking and molecular dynamics simulation approach.	Water	91-96	aquaporin 1 (Colton blood group)	Homo sapiens	105-116
18436890-2	2008	Experimental studies suggest that astrocytic endothelin-1 (ET-1) has deleterious effects on water homeostasis, cerebral edema, and blood brain barrier (BBB) integrity, which contribute to more severe ischemic brain injury.	Water	92-97	endothelin 1	Homo sapiens	59-63
18611377-6	2008	The key active site residues and the components of the Asp*water*Mg2+ network are conserved in the catalytic cores of the mammalian signaling DAG kinases, indicating that these enzymes use the same mechanism and have similar structures as DgkB.	Water	59-64	diacylglycerol kinase beta	Homo sapiens	239-243
18601373-5	2008	This PES, denoted here as SPC/E, combines an effective, empirical water-water pair potential [Berendsen et al., J. Phys.	Water	66-71	proline rich protein gene cluster	Homo sapiens	26-29
18262351-3	2008	Samples treated by a total of 20 bed volume (BV) of 1M NaCl solution prepared in tap water with no pH adjustment were found to perform satisfactorily.	Water	85-90	SEC14 like lipid binding 2	Homo sapiens	81-84
18601373-5	2008	This PES, denoted here as SPC/E, combines an effective, empirical water-water pair potential [Berendsen et al., J. Phys.	Water	72-77	proline rich protein gene cluster	Homo sapiens	26-29
18442866-7	2008	In this particular case it could be shown that the precipitation effect of PEG on IFN-alpha in water-filled pores plays a crucial role for the overall control of protein release.	Water	95-100	interferon alpha 1	Homo sapiens	82-91
18578860-9	2008	Our study on time course and correlations among water metabolism, degeneration and apoptosis of vasopressin neurons suggested that there should be an efficient therapeutic window in which irreversible CDI might be prevented by anti-apoptosis.	Water	48-53	arginine vasopressin	Rattus norvegicus	96-107
18538351-10	2008	Thus, modulation of AQP1 expression by maternal hormones may regulate invasion and fetal-placental-amnion water homeostasis during gestation.	Water	106-111	aquaporin 1 (Colton blood group)	Homo sapiens	20-24
18390544-4	2008	Monovalent cytochrome c binding is correlated with conformational changes of the Rieske head domain and subunit QCR6p and with a higher number of interfacial water molecules bound to cytochrome c(1).	Water	158-163	cytochrome c, somatic	Homo sapiens	11-23
18390544-4	2008	Monovalent cytochrome c binding is correlated with conformational changes of the Rieske head domain and subunit QCR6p and with a higher number of interfacial water molecules bound to cytochrome c(1).	Water	158-163	cytochrome c, somatic	Homo sapiens	183-195
18055108-9	2008	The sorption capacity of Cd(II), Cr(III) and Pb(II) onto the resin was 75.0, 68.2, 82.7 micromol g(-1) resin in DI water and 54.1, 46.5 and 55.7 micromol g(-1) resin in leachate, respectively.	Water	115-120	submaxillary gland androgen regulated protein 3B	Homo sapiens	45-51
18498184-6	2008	At high concentrations, the intensity ratio of the vibronic peaks of pyrene, I1/I3, (=0.68) is very close to published values for deoxycholate micelles, indicating that the probe is located in a region with a very low polarity and far from water.	Water	240-245	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	77-82
18503269-2	2008	MCH behaved as a surface active peptide, forming stable monolayers at a lipid-free air-water interface, with an equilibrium spreading pressure, a collapse pressure, and a minimal molecular area of 11 mN/m, 13 mN/m, and 140 A (2), respectively.	Water	87-92	pro-melanin concentrating hormone	Homo sapiens	0-3
18503269-5	2008	The binding of MCH to the dpPC-water interface had a K d = 930 nM at 10 mN/m.	Water	31-36	pro-melanin concentrating hormone	Homo sapiens	15-18
18093733-0	2008	Adsorptive removal of As(V) and As(III) from water by a Zr(IV)-loaded orange waste gel.	Water	45-50	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	22-27
18486126-0	2008	Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent.	Water	68-73	arginine vasopressin	Homo sapiens	15-26
18486126-7	2008	Exposure to a hypotonic medium caused an immediate (within one min) increase in cell water volume (demonstrated by decrease of fluorescence quenching of calcein), part of which was dependent upon the presence of vasopressin, added at a concentration of 1 x 10(-8) M. This vasopressin-dependent component persisted throughout the duration of the experiment (22 min).	Water	85-90	arginine vasopressin	Homo sapiens	212-223
18486126-7	2008	Exposure to a hypotonic medium caused an immediate (within one min) increase in cell water volume (demonstrated by decrease of fluorescence quenching of calcein), part of which was dependent upon the presence of vasopressin, added at a concentration of 1 x 10(-8) M. This vasopressin-dependent component persisted throughout the duration of the experiment (22 min).	Water	85-90	arginine vasopressin	Homo sapiens	272-283
18545666-8	2008	Like this, high H(2)O(2) or directed mutation of redox-sensitive ERK2 Cys(214) impeded binding to MEK1/2, caused ERK2 retention in mitochondria and restricted shuttle to nuclei.	Water	16-21	mitogen-activated protein kinase 1	Mus musculus	113-117
18478141-1	2008	The newly synthesized water-soluble cyclodiphosphazane ligands and their gold(I) complexes inhibit HeLa cell proliferation by activating p53 protein and inducing apoptosis.	Water	22-27	tumor protein p53	Homo sapiens	137-140
18452333-3	2008	For DMPC-based biomembranes, polymers whose PPO chain length is less than that of the bilayer thickness insert weakly into the membrane with the PEO blocks on the same side of the bilayer, leading to delocalization of the PEO at the membrane-water interface.	Water	242-247	protoporphyrinogen oxidase	Homo sapiens	44-47
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	Water	119-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	Water	168-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
18522817-2	2008	A new study reveals how an extracellular protein--Spam--helps mechanosensory organs in the fruit fly to withstand the effects of the water loss that accompanies heat shock.	Water	133-138	eyes shut	Drosophila melanogaster	50-54
18322017-3	2008	Bartter"s syndrome represents a group of hereditary salt- and water-losing renal tubulopathies caused by loss-of-function mutations in proteins mediating or regulating salt transport in the thick ascending limb (TAL) of Henle"s loop.	Water	62-67	talipes	Mus musculus	212-215
18520053-3	2008	We previously reported that intact fecal water samples from human volunteers significantly decreased prostaglandin production and COX-2 protein expression in colonic cells.	Water	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
18499462-2	2008	Resveratrol has to be bound by human serum albumin (HSA) to keep a high concentration in serum, since its solubility is low in water.	Water	127-132	albumin	Homo sapiens	37-50
18560669-4	2008	Hormonal mechanisms including the renin-angiotensin system, aldosterone, and vasopressin are involved in modifying fetal renal excretion, reabsorption of sodium and water, and regulation of vascular volume.	Water	165-170	renin	Homo sapiens	34-39
18683471-1	2008	Arginine vasopressin, a hypothalamic peptide hormone, has multiple physiological functions, including body water regulation, control of blood pressure and effects on body temperature, insulin release, corticotropin release, memory and social behaviour.	Water	107-112	arginine vasopressin	Homo sapiens	9-20
18560669-4	2008	Hormonal mechanisms including the renin-angiotensin system, aldosterone, and vasopressin are involved in modifying fetal renal excretion, reabsorption of sodium and water, and regulation of vascular volume.	Water	165-170	arginine vasopressin	Homo sapiens	77-88
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	163-166	cell adhesion molecule 1	Homo sapiens	32-35
24459522-2	2008	The most important physiological function of vasopressin is the maintenance of water homeostasis through interaction with V2 receptors in the kidney.	Water	79-84	arginine vasopressin	Homo sapiens	45-56
26065778-0	2008	Estimation of water activity from pH and  Brix values of some food products.	Water	14-19	biogenesis of ribosomes BRX1	Homo sapiens	42-46
26065778-1	2008	In this study, a predictive model for the estimation of water activity (aw(25 C)) as a function of pH (1.00-8.00) and  Brix (0-82.00) values of simulated food solutions (SFS) was developed, through response surface methodology.	Water	56-61	biogenesis of ribosomes BRX1	Homo sapiens	119-123
18161687-2	2008	The only difference between the two PDE5 structures exists in the catalytic, second bridging ligand (BL2) which is HO- or H2O.	Water	122-125	phosphodiesterase 5A	Homo sapiens	36-40
18161687-2	2008	The only difference between the two PDE5 structures exists in the catalytic, second bridging ligand (BL2) which is HO- or H2O.	Water	122-125	cell adhesion molecule 1	Homo sapiens	101-104
20694082-2	2008	Tolvaptan is a vasopressin V(2) receptor antagonist that blocks the effect of arginine vasopressin (AVP) in reabsorbing water from the collecting ducts of the nephrons in congestive heart failure.	Water	120-125	arginine vasopressin receptor 2	Homo sapiens	15-40
20694082-10	2008	Free water excretion in fluid-overloaded patients vulnerable to cardiorenal compromise with standard diuretic therapy makes V(2) vasopressin receptor blockade an attractive adjunct to standard medical therapy aimed at reducing congestion in AHFS.	Water	5-10	arginine vasopressin	Homo sapiens	129-140
18493807-13	2008	Twelve of the marine water samples completely inhibited the expression of CYP19 without affecting E2 production; inhibition of CYP17 expression was observed only in one of the samples while expression of CYP11beta2 was induced as much as five- and ninefold after exposure of cells to extracts from two locations.	Water	21-26	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	74-79
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	163-166	phosphodiesterase 5A	Homo sapiens	54-58
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	163-166	cell adhesion molecule 1	Homo sapiens	59-62
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	163-166	cell adhesion molecule 1	Homo sapiens	59-62
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	163-166	phosphodiesterase 5A	Homo sapiens	175-179
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	163-166	cell adhesion molecule 1	Homo sapiens	59-62
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	186-189	cell adhesion molecule 1	Homo sapiens	32-35
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	186-189	phosphodiesterase 5A	Homo sapiens	54-58
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	186-189	cell adhesion molecule 1	Homo sapiens	59-62
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	186-189	cell adhesion molecule 1	Homo sapiens	59-62
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	186-189	phosphodiesterase 5A	Homo sapiens	175-179
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Water	186-189	cell adhesion molecule 1	Homo sapiens	59-62
18161687-5	2008	The PDE5(BL2 = H2O) geometries optimized by using the QM/MM method in different ways show strong couplings between these important factors.	Water	15-18	phosphodiesterase 5A	Homo sapiens	4-8
18161687-5	2008	The PDE5(BL2 = H2O) geometries optimized by using the QM/MM method in different ways show strong couplings between these important factors.	Water	15-18	cell adhesion molecule 1	Homo sapiens	9-12
18161687-6	2008	It is interesting to note that the PDE5(BL2 = HO-) and PDE5(BL2 = H2O) geometries determined by the QM/MM calculations neglecting these three factors are all consistent with the corresponding geometries determined by the QM/MM calculations that account for all of these three factors.	Water	66-69	phosphodiesterase 5A	Homo sapiens	35-39
18161687-6	2008	It is interesting to note that the PDE5(BL2 = HO-) and PDE5(BL2 = H2O) geometries determined by the QM/MM calculations neglecting these three factors are all consistent with the corresponding geometries determined by the QM/MM calculations that account for all of these three factors.	Water	66-69	phosphodiesterase 5A	Homo sapiens	55-59
18161687-6	2008	It is interesting to note that the PDE5(BL2 = HO-) and PDE5(BL2 = H2O) geometries determined by the QM/MM calculations neglecting these three factors are all consistent with the corresponding geometries determined by the QM/MM calculations that account for all of these three factors.	Water	66-69	cell adhesion molecule 1	Homo sapiens	60-63
18479746-4	2008	The withdrawal-like behavior was abolished when methamphetamine (10 microM)-exposed planarians were placed into water containing nociceptin (10 microM) or when planarians co-exposed to methamphetamine (10 microM) and nociceptin (10 microM) were placed into drug-free water.	Water	112-117	prepronociceptin	Homo sapiens	129-139
18510376-6	2008	The thickness of the confined water layer can be tuned by fusing vesicles containing polyethyleneglycol (PEG)-conjugated lipids of various molecular weights to a glass substrate that has first been passivated with a sacrificial layer of bovine serum albumin (BSA).	Water	30-35	albumin	Homo sapiens	244-257
18209290-0	2008	Reduction of trihalomethane formation and detoxification of microcystins in tap water by ozonation.	Water	80-85	SEC14 like lipid binding 2	Homo sapiens	76-79
18378695-9	2008	Together, these results suggest that *O(2)(-) exits endosomes through a DIDS-sensitive chloride channel(s) and that SOD1-mediated dismutation of *O(2)(-) at the endosomal surface may produce the localized H(2)O(2) required for redox-activation of NF-kappaB.	Water	205-210	superoxide dismutase 1	Homo sapiens	116-120
18378695-9	2008	Together, these results suggest that *O(2)(-) exits endosomes through a DIDS-sensitive chloride channel(s) and that SOD1-mediated dismutation of *O(2)(-) at the endosomal surface may produce the localized H(2)O(2) required for redox-activation of NF-kappaB.	Water	205-210	nuclear factor kappa B subunit 1	Homo sapiens	247-256
18378702-5	2008	The functionally essential residues and water molecules are well defined and play a key role in the iterative activation of BACE1.	Water	40-45	beta-secretase 1	Homo sapiens	124-129
18378702-6	2008	We further describe the crystal structure of the dehydrated form of BACE1, showing that BACE1 activity is dependent on the dynamics of a catalytically required Asp-bound water molecule, which directly affects its catalytic properties.	Water	170-175	beta-secretase 1	Homo sapiens	68-73
18378702-6	2008	We further describe the crystal structure of the dehydrated form of BACE1, showing that BACE1 activity is dependent on the dynamics of a catalytically required Asp-bound water molecule, which directly affects its catalytic properties.	Water	170-175	beta-secretase 1	Homo sapiens	88-93
18479746-4	2008	The withdrawal-like behavior was abolished when methamphetamine (10 microM)-exposed planarians were placed into water containing nociceptin (10 microM) or when planarians co-exposed to methamphetamine (10 microM) and nociceptin (10 microM) were placed into drug-free water.	Water	267-272	prepronociceptin	Homo sapiens	217-227
18607342-5	2008	It has been demonstrated in an experimental ICH that EPO intervenes in the inflammatory process, reduces brain water content, hemorrhage volume and hemispheric atrophy, promotes cell survival, preserves cerebral blood flow, has antiapoptotic protective function against oxidative stress and excitotoxic damage.	Water	111-116	erythropoietin	Homo sapiens	53-56
18426236-7	2008	The pyroelectricity of water ice, not previously reported, is in reasonable agreement with that predicted using harmonic analysis of a model system of SPC ice.	Water	23-28	proline rich protein gene cluster	Homo sapiens	151-154
18405950-7	2008	Several genes were in common between the EtOH and both the SAC and water groups in the synaptic transmission (e.g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories.	Water	67-72	caveolin 2	Rattus norvegicus	116-120
18405950-7	2008	Several genes were in common between the EtOH and both the SAC and water groups in the synaptic transmission (e.g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories.	Water	67-72	gamma-aminobutyric acid type A receptor subunit beta 2	Rattus norvegicus	129-135
18405950-7	2008	Several genes were in common between the EtOH and both the SAC and water groups in the synaptic transmission (e.g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories.	Water	67-72	ferritin light chain 1	Rattus norvegicus	182-186
18262434-4	2008	In synthesis Ach via nAChR or mAChR appears to be involved in the regulation of vital cell functions: proliferation, differentiation, organization of the cytoskeleton, cell-cell contact, ciliary activity, migration, secretion and absorption of ions, water and mucus.	Water	250-255	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	21-26
19035047-5	2008	RESULTS: Under the same lead exposure, no significant differences were observed in blood lead, however, brain lead level showed higher in drinking purified water group than that in tap water group.	Water	185-190	nuclear RNA export factor 1	Rattus norvegicus	181-184
19035047-6	2008	Expression of NR1, NR2A and NR2B in hippocampus of the rats drinking purified water was lower than those drinking tap water, especially at low lead exposure (50 mg/L) (P &lt; 0.05).	Water	78-83	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	19-23
19035047-6	2008	Expression of NR1, NR2A and NR2B in hippocampus of the rats drinking purified water was lower than those drinking tap water, especially at low lead exposure (50 mg/L) (P &lt; 0.05).	Water	118-123	nuclear RNA export factor 1	Rattus norvegicus	114-117
19035047-8	2008	CONCLUSION: Compared with drinking tap water, drinking purified water might increase the accumulation of brain lead, lower NR1, NR2A, NR2B expression and delay the spatial learning and memory ability under chronic lead exposure in water.	Water	64-69	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	128-132
19035047-8	2008	CONCLUSION: Compared with drinking tap water, drinking purified water might increase the accumulation of brain lead, lower NR1, NR2A, NR2B expression and delay the spatial learning and memory ability under chronic lead exposure in water.	Water	64-69	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	128-132
18552202-1	2008	The DEHYDRATION-RESPONSIVE ELEMENT BINDING PROTEIN2A (DREB2A) transcription factor controls water deficit-inducible gene expression and requires posttranslational modification for its activation.	Water	92-97	DRE-binding protein 2A	Arabidopsis thaliana	4-52
18552202-1	2008	The DEHYDRATION-RESPONSIVE ELEMENT BINDING PROTEIN2A (DREB2A) transcription factor controls water deficit-inducible gene expression and requires posttranslational modification for its activation.	Water	92-97	DRE-binding protein 2A	Arabidopsis thaliana	54-60
18325559-5	2008	However, both the water- and organic-solvent-soluble particulate fractions induced TNFalpha production and apoptosis and had some other cytotoxic effects.	Water	18-23	tumor necrosis factor	Mus musculus	83-91
18454513-7	2008	The additional V2 phase appearing in the P123-EAN system is attributed to the higher affinity for the relatively hydrophobic PPO blocks to EAN than to water, which might reduce the effective area of the solvophilic headgroup and increase the volume of the solvophobic part.	Water	151-156	protoporphyrinogen oxidase	Homo sapiens	125-128
18433162-3	2008	At a low concentration (0.3 M), the sparingly water soluble IL ([pmim][BF4]) penetrates the hydrophobic PPO core of the P123 micelles.	Water	46-51	protoporphyrinogen oxidase	Homo sapiens	104-107
18433164-10	2008	Reducing the SPC water dipole moment by 5% (i.e., decreasing water partial charges in magnitude) in GCMC calculations does allow reproducing the experimental water/silicalite isotherm at 300 K.	Water	17-22	proline rich protein gene cluster	Homo sapiens	13-16
18433164-10	2008	Reducing the SPC water dipole moment by 5% (i.e., decreasing water partial charges in magnitude) in GCMC calculations does allow reproducing the experimental water/silicalite isotherm at 300 K.	Water	61-66	proline rich protein gene cluster	Homo sapiens	13-16
18433164-10	2008	Reducing the SPC water dipole moment by 5% (i.e., decreasing water partial charges in magnitude) in GCMC calculations does allow reproducing the experimental water/silicalite isotherm at 300 K.	Water	61-66	proline rich protein gene cluster	Homo sapiens	13-16
18412376-6	2008	The hydrophobic interactions between the hydrophobic tip and polymer surfaces in water were greatly reduced with the segregated PME NMA blocks.	Water	81-86	cystatin B	Homo sapiens	128-131
18480265-5	2008	ATN-224-mediated inhibition of SOD1 in tumor and endothelial cells prevents the formation of sufficiently high levels of H(2)O(2), resulting in the protection of PTPs from H(2)O(2)-mediated oxidation.	Water	121-126	superoxide dismutase 1	Homo sapiens	31-35
18440535-5	2008	Blockade of UII actions by administration of UT receptor antagonist, urantide, in anaesthetised rats, indicates that endogenous UII lowers renal filtration rates and excretion of water and ions.	Water	179-184	urotensin 2	Rattus norvegicus	12-15
18439024-8	2008	When it interacts with DPC, LL-37 is adsorbed on the surface of the micelle with the hydrophilic face exposed to the water phase and the hydrophobic face buried in the micelle hydrocarbon region.	Water	117-122	cathelicidin antimicrobial peptide	Homo sapiens	28-33
18440535-5	2008	Blockade of UII actions by administration of UT receptor antagonist, urantide, in anaesthetised rats, indicates that endogenous UII lowers renal filtration rates and excretion of water and ions.	Water	179-184	urotensin 2	Rattus norvegicus	128-131
18465925-0	2008	Exp6-polar thermodynamics of dense supercritical water.	Water	49-54	exportin 6	Homo sapiens	0-4
18273832-8	2008	The mechanical properties, thermal stability, and water resistance of the CaCO3/SPI nanocomposites were significantly improved as a result of the nanosized effects.	Water	50-55	chromogranin A	Homo sapiens	80-83
18437152-10	2008	In contrast, catalase, which catalyzes the conversion of hydrogen peroxide to oxygen and water, inhibited neutrophil-endothelial adhesion in the preeclamptic group (8.1 +/- 0.5%, P &lt; 0.01).	Water	89-94	catalase	Homo sapiens	13-21
18287219-2	2008	Baseline daily water intake in Agt-/- mice was approximately threefold that of WT mice because of a renal developmental disorder of the urinary concentrating mechanisms in Agt-/- mice.	Water	15-20	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	31-34
18469463-6	2008	The proposed method was applied to the determination of Pb(II), Cd(II) and Zn(II) in water samples with satisfactory results.	Water	85-90	submaxillary gland androgen regulated protein 3B	Homo sapiens	56-62
18394632-5	2008	The optimised method allowed the determination of the analyte at the low ngL(-1) level in tap and sewage water.	Water	105-110	leucine rich repeat containing 4C	Homo sapiens	73-79
18453433-4	2008	Streambed processes potentially reduced 45 to 75% of ground water NO3(-) before discharge to surface water.	Water	60-65	NBL1, DAN family BMP antagonist	Homo sapiens	66-69
18453433-7	2008	Denitrification of NO3(-) was largely independent of nitrification because both stream and ground water were sources of NO3(-).	Water	98-103	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
18453433-10	2008	Biotic processing potentially removed 75% of ground water NO3(-) at this site, suggesting an important role for photosynthetic assimilation of ground water NO3(-) relative to subsurface denitrification as water passed directly through benthic diatom beds.	Water	52-57	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
18453433-10	2008	Biotic processing potentially removed 75% of ground water NO3(-) at this site, suggesting an important role for photosynthetic assimilation of ground water NO3(-) relative to subsurface denitrification as water passed directly through benthic diatom beds.	Water	150-155	NBL1, DAN family BMP antagonist	Homo sapiens	156-159
18453433-10	2008	Biotic processing potentially removed 75% of ground water NO3(-) at this site, suggesting an important role for photosynthetic assimilation of ground water NO3(-) relative to subsurface denitrification as water passed directly through benthic diatom beds.	Water	150-155	NBL1, DAN family BMP antagonist	Homo sapiens	156-159
18305094-1	2008	Endothelin-1 (ET-1) plays an important role in the regulation of salt and water excretion in the kidney.	Water	74-79	endothelin 1	Rattus norvegicus	0-12
18305094-1	2008	Endothelin-1 (ET-1) plays an important role in the regulation of salt and water excretion in the kidney.	Water	74-79	endothelin 1	Rattus norvegicus	14-18
18595272-3	2008	To date, there are no tools to assess the consequences of such flood pulse alterations, leaving the Tonle Sap underrated in water-resources use and planning.	Water	124-129	SH2 domain containing 1A	Homo sapiens	106-109
18465925-1	2008	We introduce a simple polar fluid model for the thermodynamics of dense supercritical water based on a Buckingham (exp-6) core and point dipole representation of the water molecule.	Water	86-91	exportin 6	Homo sapiens	115-120
18465944-1	2008	Reversible foldings of a beta-hairpin peptide, chignolin, by recently invented hybrid Hamiltonian replica exchange molecular dynamics simulations based on Poisson-Boltzmann model in explicit water are demonstrated.	Water	191-196	amyloid beta precursor protein	Homo sapiens	23-29
18289663-7	2008	Comparison of adsorption to ion-exchange resins and neutral ODS leads to the conclusion that the apparent standard free-energy of adsorption Delta Gads( degrees ) of Lys, HSA, and IgG is not large in comparison to thermal energy due to energy-compensating interactions between water, protein, and ion-exchange surfaces that leaves a small net Delta Gads( degrees ).	Water	277-282	lysozyme	Homo sapiens	166-169
18325656-6	2008	Assuming a reversible two-state model for cyt c unfolding, Delta G(H2O), Cm and m values were determined to be 8.32+/-0.7 kcal mol(-1), 1.53+/-0.19 kcalmol(-1)M(-1) and 5.03 M, respectively.	Water	67-70	cytochrome c, somatic	Homo sapiens	42-47
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Water	173-178	solute carrier family 4 member 4	Rattus norvegicus	77-82
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Water	284-289	solute carrier family 4 member 4	Rattus norvegicus	77-82
18483329-1	2008	Catalase, a ubiquitous heme enzyme, catalyzes conversion of hydrogen peroxide to water and molecular oxygen, protecting cells from oxidative stress.	Water	81-86	catalase	Homo sapiens	0-8
18456050-14	2008	The relatively high bond strengths for groups TSC-BSIL and TSC-SIL decreased significantly after 150 days of water storage to 13.5 +/- 1.6 and 11.8 +/- 1.2 MPa, respectively (P&lt;.001).	Water	109-114	TSC complex subunit 1	Homo sapiens	46-62
18522101-12	2008	The NO3-/C2H5OH actinometer is particularly useful for large volumes of water in industrial high-intensity UV photoreactors as the actinometer solution can be safely disposed.	Water	72-77	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
18196297-1	2008	Quantum mechanical/molecular mechanical (QM/MM) theoretical calculations were performed for the pentacoordinate Mn(III) and water-bound resting states of the Mn-reconstituted mutant of cytochrome P450(cam) (Mn-P450(cam)) in order to obtain insights into their characters, especially, their spin state ordering.	Water	124-129	calmodulin 3	Homo sapiens	185-205
17928136-1	2008	This work describes a procedure for the separation-preconcentration of Fe(III), Pb(II) and Cr(III) from some water samples using a column-filled Amberlite XAD-2000 resin.	Water	109-114	submaxillary gland androgen regulated protein 3B	Homo sapiens	80-98
18410160-6	2008	When less than 1 wt % of alpha-lactalbumin was added into the system, the w/o droplets became nonspherical and larger in volume, corresponding to an increase in water uptake into the droplets.	Water	161-166	lactalbumin alpha	Homo sapiens	25-42
18335184-2	2008	Effects of vasopressin via V1(a) and V2 receptors are closely implicated in a variety of water-retaining diseases and cardiovascular diseases, including heart failure, hyponatremia, hypertension, renal diseases, syndrome of inappropriate antidiuretic hormone secretion, cirrhosis, and ocular hypertension.	Water	89-94	arginine vasopressin	Homo sapiens	11-22
18601534-3	2008	We will address the ability of water-stabilized QDs to behave as effective fluorescence resonance energy transfer (FRET) donors in cells upon transferrin-receptor-(TFR) mediated endocytosis.	Water	31-36	transferrin	Homo sapiens	142-153
18297375-1	2008	The interaction between bergenin and human serum albumin (HSA) in AOT/isooctane/water microemulsions was studied by fluorescence quenching technique in combination with UV absorption spectroscopy, circular dichroism (CD) spectroscopy and dynamic light scattering (DLS) technique.	Water	80-85	albumin	Homo sapiens	43-56
18544259-1	2008	OBJECTIVE: Aquaporin-1 (AQP1), the osmotic water channel, is located in choroidal plexus, which facilitates the cerebrospinal fluid formation in central nervous system (CNS).	Water	43-48	aquaporin 1 (Colton blood group)	Homo sapiens	11-22
17940875-1	2008	Arginine vasopressin (AVP) is known to a neuropeptide that plays important roles in water conservation, sodium homeostasis, and in the regulation of serum osmolality.	Water	84-89	arginine vasopressin	Rattus norvegicus	9-20
17940875-1	2008	Arginine vasopressin (AVP) is known to a neuropeptide that plays important roles in water conservation, sodium homeostasis, and in the regulation of serum osmolality.	Water	84-89	arginine vasopressin	Rattus norvegicus	22-25
18544259-1	2008	OBJECTIVE: Aquaporin-1 (AQP1), the osmotic water channel, is located in choroidal plexus, which facilitates the cerebrospinal fluid formation in central nervous system (CNS).	Water	43-48	aquaporin 1 (Colton blood group)	Homo sapiens	24-28
18544259-2	2008	AQP1 has been speculated to maintain the homeostasis of intracellular and extracellular water in the brain, while the intractable epilepsy (IE) may be related to the imbalance in water and ion homeostasis.	Water	88-93	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
18544259-6	2008	CONCLUSION: For the first time, we showed high expression of AQP1 water channels in IE cases and suggest two mechanisms to explain this finding.	Water	66-71	aquaporin 1 (Colton blood group)	Homo sapiens	61-65
18519086-1	2008	Water reabsorption in the renal collecting duct is regulated by the antidiuretic hormone vasopressin (AVP).	Water	0-5	arginine vasopressin	Homo sapiens	68-100
18280259-3	2008	In contrast, there was a dose dependent increase in intracellular NO (p&lt;0.001, n=8) following MPO (0.025 microM) treatment, which was further enhanced (p&lt;0.0003, n=8) by addition of H(2)O(2).	Water	188-193	myeloperoxidase	Homo sapiens	97-100
18280259-10	2008	Although MPO can influence cellular oxidative stress, particularly in the presence of H(2)O(2), 3NT formation requires the presence of high concentrations of NO(2)(-) in the milieu.	Water	86-91	myeloperoxidase	Homo sapiens	9-12
18519086-1	2008	Water reabsorption in the renal collecting duct is regulated by the antidiuretic hormone vasopressin (AVP).	Water	0-5	arginine vasopressin	Homo sapiens	102-105
18519086-2	2008	When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-urine into the interstitium.	Water	140-145	arginine vasopressin receptor 2	Homo sapiens	9-32
18519086-2	2008	When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-urine into the interstitium.	Water	140-145	arginine vasopressin	Homo sapiens	116-119
18519086-2	2008	When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-urine into the interstitium.	Water	217-222	arginine vasopressin receptor 2	Homo sapiens	9-32
18519086-2	2008	When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-urine into the interstitium.	Water	217-222	arginine vasopressin	Homo sapiens	116-119
18519086-3	2008	The essential role of the vasopressin V2 receptor and AQP2 in the maintenance of body water homeostasis became clear when it was shown that mutations in their genes cause nephrogenic diabetes insipidus, a disorder in which the kidney is unable to concentrate urine in response to AVP.	Water	86-91	arginine vasopressin receptor 2	Homo sapiens	26-49
18519088-0	2008	Vasopressin antagonists in the treatment of water-retaining disorders.	Water	44-49	arginine vasopressin	Homo sapiens	0-11
18519090-4	2008	In the kidney, the calcium-sensing receptor regulates renal calcium excretion and influences the transepithelial movement of water and other electrolytes.	Water	125-130	calcium sensing receptor	Homo sapiens	19-43
18519091-8	2008	Suppression of arginine vasopressin release by high water intake is protective.	Water	52-57	arginine vasopressin	Rattus norvegicus	24-35
18405683-4	2008	The interaction and adsorption of bovine serum albumin (BSA) and meso-tetrakis(4-sulfonatophenyl)porphyrin (TPPS) at toluene-water interface were studied successfully by the coupling technique of total internal reflection synchronous fluorescence (TIRSF).	Water	125-130	albumin	Homo sapiens	41-54
18280225-2	2008	AQP1 and AQP5 expressed in lung provide the principal route for osmotically driven water transport.	Water	83-88	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
18353683-3	2008	This study demonstrates that the water resonance frequency is directly shifted by water-macromolecule exchange processes (0.040 ppm/mM for bovine serum albumin) and might be a major source of contribution to in vivo phase image contrast.	Water	33-38	albumin	Homo sapiens	146-159
21202222-1	2008	In the mol-ecule of the title compound, [Co(C(6)H(4)NO(2))(2)(H(2)O)(2)], the coordination environment around the Co(II) atom is distorted octahedral; two N and two O atoms of the pyridine-2-carboxylate ligands lie in the equatorial plane and the two water O atoms in the axial positions.	Water	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
18353683-3	2008	This study demonstrates that the water resonance frequency is directly shifted by water-macromolecule exchange processes (0.040 ppm/mM for bovine serum albumin) and might be a major source of contribution to in vivo phase image contrast.	Water	82-87	albumin	Homo sapiens	146-159
18425166-4	2008	A detection sensitivity of 2 x 10(-6) cm(-1) Hz(-(1/2)) (for signal-to-noise ratio SNR=1) is achieved, corresponding to detection limits of 900 ppb (parts in 10(9)) for MMA, 450 ppb for DMA, and 120 ppb for TMA in mixtures containing H2O and CO2 with concentrations of up to those present in human breath (2% and 5%, respectively).	Water	234-237	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	83-88
18327926-6	2008	Up to five solvent H2O molecules can stay around solute NO3(-) anion in structures having an inter-water hydrogen-bonded cyclic network.	Water	19-22	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
18327926-6	2008	Up to five solvent H2O molecules can stay around solute NO3(-) anion in structures having an inter-water hydrogen-bonded cyclic network.	Water	99-104	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
18343226-4	2008	Conversely inhibition of extracellular catalase led to a striking inactivation of secreted cysteine cathepsins by H(2)O(2).	Water	114-119	catalase	Homo sapiens	39-47
18390724-11	2008	We suggest that constitutively produced endogenous IL-10 ameliorates the development of EAU by suppressing de novo priming of Ag-specific T cells and inhibiting the recruitment and/or function of inflammatory leukocytes, rather than by inhibiting local Ag presentation within the eye.	Water	88-91	interleukin 10	Mus musculus	51-56
18390724-2	2008	The immunosuppressive cytokine IL-10 regulates EAU susceptibility and may be a factor in genetic resistance to EAU.	Water	47-50	interleukin 10	Mus musculus	31-36
18298058-1	2008	Reaction of [NEt4]2[ReBr3(CO)3] with 2,4-pentanedione (acac) yields a complex of the type fac-Re(acac)(OH2)(CO)3 (1) under aqueous conditions.	Water	103-107	FA complementation group C	Homo sapiens	90-93
18348558-0	2008	Interaction of zinc tetrasulfonated phthalocyanine with cytochrome C in water and Triton-X 100 micelles.	Water	72-77	cytochrome c, somatic	Homo sapiens	56-68
18348558-1	2008	The interaction of a zinc tetrasulfonated phthalocyanine with cytochrome c was studied using steady-state spectroscopic techniques and time-correlated single photon counting in water and Triton-X 100 micelles.	Water	177-182	cytochrome c, somatic	Homo sapiens	62-74
18330982-0	2008	Water-soluble 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (dmoPTA) as a polydentate ligand: synthesis of [RuClCp(PPh3)-mu-dmoPTA-1kappaP:2kappa2N,N"-Co(acac-kappa2O,O")2].H2O.	Water	0-5	caveolin 1	Homo sapiens	125-129
17629774-4	2008	In the pre-associated Abeta, Ntau atom of imidazole ring of His14, O atom of carbonyl of main-chain and two O atoms of water occupied the four ligand positions of the complex.	Water	119-124	amyloid beta precursor protein	Homo sapiens	22-27
18371493-1	2008	In mitochondria and many aerobic bacteria cytochrome c oxidase is the terminal enzyme of the respiratory chain where it catalyses the reduction of oxygen to water.	Water	157-162	cytochrome c, somatic	Homo sapiens	42-54
18324926-0	2008	Synthesis of water soluble bis-triazenoquinazolines: an unusual predicted mode of binding to the epidermal growth factor receptor tyrosine kinase.	Water	13-18	epidermal growth factor receptor	Homo sapiens	97-129
18241265-12	2008	CONCLUSIONS: This is the first demonstration that elevated AQP3 results in the retention of epidermal water, causing the taut, wrinkle-free skin phenotype of the DHCR24-/- mice.	Water	102-107	aquaporin 3	Mus musculus	59-63
18188600-3	2008	Among these isoforms, AQP6 is considered to function not as water channel, but as an anion channel.	Water	60-65	aquaporin 6	Rattus norvegicus	22-26
18188600-10	2008	These results suggest that AQP6 participates in water and anion transport in plasma membranes near tight junctions and secretory granule membranes in rat parotid acinar cells.	Water	48-53	aquaporin 6	Rattus norvegicus	27-31
18431320-1	2008	AIM: Hyponatremia, an electrolyte disturbance, can be due to loss of solutes or to an increase of ""free"" water concentration, predominantly caused by excessive antidiuretic hormone (ADH) secretion.	Water	107-112	arginine vasopressin	Homo sapiens	162-182
18194855-2	2008	This review focuses on AQP0 and AQP4, which in addition to forming water channels also appear to play a role in cell adhesion.	Water	67-72	major intrinsic protein of lens fiber	Homo sapiens	23-27
18228200-5	2008	Chronic exposure over 12 months to aluminium sulphate in drinking water resulted in deposition of Abeta similar to that seen in congophilic amyloid angiopathy (CAA) in humans and a reduction in neuronal expression of GRP78 similar to what has previously been observed in Alzheimer"s disease.	Water	66-71	amyloid beta precursor protein	Homo sapiens	98-103
18228200-5	2008	Chronic exposure over 12 months to aluminium sulphate in drinking water resulted in deposition of Abeta similar to that seen in congophilic amyloid angiopathy (CAA) in humans and a reduction in neuronal expression of GRP78 similar to what has previously been observed in Alzheimer"s disease.	Water	66-71	heat shock protein family A (Hsp70) member 5	Homo sapiens	217-222
18713728-4	2008	In contrast, CXCL1/KC(- /-) and wild-type C57BL/6J mice provided water showed no signs of inflammation and, at this concentration of DSS, wild-type mice showed only minimal histopathology, but significantly more infiltrating neutrophils.	Water	65-70	chemokine (C-X-C motif) ligand 1	Mus musculus	13-18
17994640-1	2008	The structure of the antimicrobial peptide NK-2 has been studied at the air-water interface and in different solutions using spectroscopic methods such as circular dichroism (CD) and infrared reflection absorption spectroscopy (IRRAS) as well as specular X-ray reflectivity (XR).	Water	76-81	NK2 homeobox 1	Homo sapiens	43-47
17994640-2	2008	NK-2 adopts an unordered structure in water, buffer, and in the presence of monomeric cationic and noncharged amphiphiles.	Water	38-43	NK2 homeobox 1	Homo sapiens	0-4
17994640-5	2008	In contrast, no adsorption was observed if NK-2 is dissolved in water.	Water	64-69	NK2 homeobox 1	Homo sapiens	43-47
18275976-1	2008	Aquaporin 1 (AQP1) was first purified from red blood cell membranes and is now known to be an osmolarity-driven water transporter that is widely expressed in many epithelial and endothelial cells outside the brain.	Water	112-117	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
18275976-1	2008	Aquaporin 1 (AQP1) was first purified from red blood cell membranes and is now known to be an osmolarity-driven water transporter that is widely expressed in many epithelial and endothelial cells outside the brain.	Water	112-117	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
18431320-1	2008	AIM: Hyponatremia, an electrolyte disturbance, can be due to loss of solutes or to an increase of ""free"" water concentration, predominantly caused by excessive antidiuretic hormone (ADH) secretion.	Water	107-112	arginine vasopressin	Homo sapiens	184-187
18331000-0	2008	Immobilizing a drop of water: fabricating highly hydrophobic surfaces that pin water droplets.	Water	23-28	dynein light chain LC8-type 1	Homo sapiens	75-78
18331000-0	2008	Immobilizing a drop of water: fabricating highly hydrophobic surfaces that pin water droplets.	Water	79-84	dynein light chain LC8-type 1	Homo sapiens	75-78
18331000-1	2008	We describe the fabrication of a patterned, hydrophobic silicon substrate that can pin a water droplet despite its large contact angle.	Water	89-94	dynein light chain LC8-type 1	Homo sapiens	83-86
18239072-3	2008	Here, it is reported that in the V233A variant of ml8bTIM (A-TIM), three important properties of the wild-type TIM active site have been restored: (i) the structural properties of loop-7, (ii) the binding site of a conserved water molecule between loop-7 and loop-8 and (iii) the binding site of the phosphate moiety.	Water	225-230	triosephosphate isomerase 1	Homo sapiens	54-57
18441212-4	2008	To more comprehensively identify genes involved in the downstream pathways affected by the ATHK1-mediated response to water stress, we created a large-scale summary of expression data, termed the AtMegaCluster.	Water	118-123	histidine kinase 1	Arabidopsis thaliana	91-96
18441212-7	2008	Since overexpression of ATHK1 results in increased water stress tolerance, our observations suggest a new top-down route to increasing drought resistance via receptor-mediated increases in sensing water status, rather than through genetically engineered changes in downstream transcription factors or specific osmolytes.	Water	51-56	histidine kinase 1	Arabidopsis thaliana	24-29
18338748-4	2008	The complexed hydrogen peroxide can then be degraded in the presence of catalase to form oxygen and water.	Water	100-105	catalase	Homo sapiens	72-80
18239072-3	2008	Here, it is reported that in the V233A variant of ml8bTIM (A-TIM), three important properties of the wild-type TIM active site have been restored: (i) the structural properties of loop-7, (ii) the binding site of a conserved water molecule between loop-7 and loop-8 and (iii) the binding site of the phosphate moiety.	Water	225-230	triosephosphate isomerase 1	Homo sapiens	61-64
18243045-5	2008	Experiment 2 was performed to investigate the effects of KBrO3 at the 0.002 ppm dose approximately contained in the tap water on rat kidneys.	Water	120-125	nuclear RNA export factor 1	Rattus norvegicus	116-119
18728836-4	2008	Activation of V2 by AVP is the key in renal water regulation and maintenance of total body volume and plasma tonicity.	Water	44-49	arginine vasopressin	Homo sapiens	20-23
18728836-6	2008	More recently, a new class of drugs, introduced as "aquaretics," has gained great attention among clinicians because of its ability to correct hyponatremia via direct competitive inhibition of AVP at V2 receptors to induce renal electrolyte-free water excretion.	Water	246-251	arginine vasopressin	Homo sapiens	193-196
18398368-9	2008	Water-operated retinas showed TUNEL-positive cells and GFAP immunofluorescence throughout Muller cell processes; lamotrigine-operated retinas showed no TUNEL-positive cells and decreased GFAP staining when compared with water-operated retinas.	Water	0-5	glial fibrillary acidic protein	Oryctolagus cuniculus	55-59
18199468-7	2008	The different behaviour was specially found for the water samples with a low level of organic compounds and when C18 extracts were highly cytotoxic.	Water	52-57	Bardet-Biedl syndrome 9	Homo sapiens	113-116
18155098-5	2008	Both male and female 5-HT(1B) mutant mice drank more sucrose than WT mice but also consumed more water.	Water	97-102	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	21-28
18376947-1	2008	We investigate the properties of geometrically modified water models by performing molecular dynamics simulations of perturbations of the extended simple point charge (SPC/E) model of water over a wide range of temperatures at 1 bar.	Water	56-61	proline rich protein gene cluster	Homo sapiens	168-171
18376947-1	2008	We investigate the properties of geometrically modified water models by performing molecular dynamics simulations of perturbations of the extended simple point charge (SPC/E) model of water over a wide range of temperatures at 1 bar.	Water	184-189	proline rich protein gene cluster	Homo sapiens	168-171
18302358-1	2008	Micellar solutions made of a fully fluorinated surfactant, LiPFN, form water-soluble complexes with lysozyme in a wide concentration range.	Water	71-76	lysozyme	Homo sapiens	100-108
18179782-3	2008	Arginine vasopressin (AVP) promotes renal water reabsorption via the V(2) receptor (V(2)R) and its levels are increased in CHF.	Water	42-47	arginine vasopressin	Rattus norvegicus	0-20
18179782-3	2008	Arginine vasopressin (AVP) promotes renal water reabsorption via the V(2) receptor (V(2)R) and its levels are increased in CHF.	Water	42-47	arginine vasopressin receptor 2	Rattus norvegicus	69-89
18206863-8	2008	As the Ara/Xyl ratio was lowered, aggregates began to form in an interval of the Ara/Xyl ratio between 0.31 and 0.23 in a water solution.	Water	122-127	ATP binding cassette subfamily C member 6	Homo sapiens	7-10
18206863-8	2008	As the Ara/Xyl ratio was lowered, aggregates began to form in an interval of the Ara/Xyl ratio between 0.31 and 0.23 in a water solution.	Water	122-127	ATP binding cassette subfamily C member 6	Homo sapiens	81-84
18218985-9	2008	Finally, PIAS1 knockdown reversed the inhibitory effect of H(2)O(2) in shear stress-induced Kruppel-like factor 2 and endothelial nitric oxide synthase expression.	Water	59-64	protein inhibitor of activated STAT 1	Mus musculus	9-14
18191166-1	2008	Chronic drinking water exposure to inorganic arsenic and its metabolites increases tumor frequency in the skin of K6/ODC transgenic mice.	Water	17-22	keratin 6	Mus musculus	114-120
18345905-3	2008	However, significant differences are found among the modified and SPC/E water models and the critical distances in which they dewet the hydrophobic surfaces of pairs of repulsive Gay-Berne particles.	Water	72-77	proline rich protein gene cluster	Homo sapiens	66-69
18307291-7	2008	Oxidation of [Au(DPPP)(PPh 3)Cl] toward Au(III) compounds and phosphine-oxides is observed upon reaction with hypochlorite in water/dimethyl sulfoxide solution, mimicking endogenous hypochlorite.	Water	126-131	caveolin 1	Homo sapiens	23-28
18335029-3	2008	We wondered whether insulin-operated signaling pathways modulate mitochondrial respiration via NO, to alternatively release complete glucose oxidation to CO(2) and H(2)O or to drive glucose storage to glycogen.	Water	164-169	insulin	Homo sapiens	20-27
18642774-6	2008	RESULTS: The expression rates of HA and CD44, and proportion of crystal retention of the tap water 1-day group were 25.0%, 25.0%, and 16.7% respectively, all not significantly different from those of the EG 1-day group (8.3%, 16.7%, and 25.0% respectively, all P &gt; 0.05).	Water	93-98	nuclear RNA export factor 1	Rattus norvegicus	89-92
18642774-7	2008	The expression rates of HA and CD44, and proportion of crystal retention of the tap water 5-day group were 33.3%, 25.0%, and 16.7% respectively, all significantly lower than those of the EG 5-day group (83.3%, 75.0%, and 66.7% respectively, all P &lt; 0.05).	Water	84-89	nuclear RNA export factor 1	Rattus norvegicus	80-83
18331623-0	2008	Freezing point osmometry of milk to determine the additional water content--an issue in general quality control and German food regulation.	Water	61-66	Weaning weight-maternal milk	Bos taurus	28-32
18260647-2	2008	After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+).	Water	116-121	tumor protein p53	Homo sapiens	30-33
18331623-4	2008	Although cow"s milk is a natural product whose water content is approximately 87%, the osmolality of milk is a significant value when the milk is collected from a larger population of animals.	Water	47-52	Weaning weight-maternal milk	Bos taurus	15-19
18331623-5	2008	This value is used in milk processing to control the water content, based on the German Food Control Regulations for Milk.	Water	53-58	Weaning weight-maternal milk	Bos taurus	22-26
18331623-5	2008	This value is used in milk processing to control the water content, based on the German Food Control Regulations for Milk.	Water	53-58	Weaning weight-maternal milk	Bos taurus	117-121
18331623-12	2008	CONCLUSION: The results observed demonstrate clearly that the additional water content of milk can be determined easily using a freezing point osmometer.	Water	73-78	Weaning weight-maternal milk	Bos taurus	90-94
18331623-13	2008	Milk samples that contain additional water have a significantly decreased osmolality, corresponding to an increased freezing point.	Water	37-42	Weaning weight-maternal milk	Bos taurus	0-4
18269278-2	2008	By employing a two-state valence-bond description for electronic structure variations of the reaction complex, the free energy curve relevant to its SN1 ionization in [emim](+)P(-)(6)) is computed via the thermodynamic integration method and compared with those in water and in acetonitrile.	Water	265-270	solute carrier family 38 member 3	Homo sapiens	149-152
18260647-5	2008	The lack of formation of a water channel is due to the positioning of the methyl substituent of the SET7/9.p53-Lys4-N(Me)H 2 (+).AdoMet complex.	Water	27-32	tumor protein p53	Homo sapiens	107-110
18260647-2	2008	After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+).	Water	116-121	tumor protein p53	Homo sapiens	153-156
18260647-2	2008	After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+).	Water	116-121	tumor protein p53	Homo sapiens	153-156
18260647-2	2008	After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+).	Water	116-121	tumor protein p53	Homo sapiens	153-156
18260647-2	2008	After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+).	Water	180-185	tumor protein p53	Homo sapiens	30-33
18260647-2	2008	After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+).	Water	180-185	tumor protein p53	Homo sapiens	153-156
18322093-6	2008	H(2)O(2) and the naturally occurring alkenyl aldehydes and 15d-PGJ(2) acted on a subset of isolated rat and mouse sensory neurons [approximately 25% of rat dorsal root ganglion (DRG) and approximately 50% of nodose ganglion neurons] to evoke a depolarizing inward current and an increase in [Ca(2+)](i) in TRPA1 expressing neurons.	Water	0-5	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	306-311
18260647-2	2008	After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+).	Water	180-185	tumor protein p53	Homo sapiens	153-156
18260647-2	2008	After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+).	Water	180-185	tumor protein p53	Homo sapiens	153-156
18260647-4	2008	Without a water channel, the substrate p53-Lys4-N(Me)H is not available because the proton dissociation p53-Lys4-N(Me)H 2 (+) --&gt; p53-Lys4-N(Me)H + H (+) does not occur.	Water	10-15	tumor protein p53	Homo sapiens	39-42
18260647-4	2008	Without a water channel, the substrate p53-Lys4-N(Me)H is not available because the proton dissociation p53-Lys4-N(Me)H 2 (+) --&gt; p53-Lys4-N(Me)H + H (+) does not occur.	Water	10-15	tumor protein p53	Homo sapiens	104-107
18260647-4	2008	Without a water channel, the substrate p53-Lys4-N(Me)H is not available because the proton dissociation p53-Lys4-N(Me)H 2 (+) --&gt; p53-Lys4-N(Me)H + H (+) does not occur.	Water	10-15	tumor protein p53	Homo sapiens	104-107
18199602-7	2008	However, A(1)R(-/-) had greater inner medullary expression of cyclooxygenase-1 under basal conditions and of the P2Y(2) and EP(3) receptor in response to water loading compared with WT mice.	Water	154-159	purinergic receptor P2Y, G-protein coupled 2	Mus musculus	113-138
18288441-7	2008	These results demonstrate the important role of vasopressin in the development of the disturbances in brain water and electrolyte balance in response to general cerebral hypoxia.	Water	108-113	arginine vasopressin	Rattus norvegicus	48-59
18275939-10	2008	Interestingly, it was observed that TAFA5 mRNA was specifically down-regulated in the PVN following water deprivation.	Water	100-105	TAFA chemokine like family member 5	Rattus norvegicus	36-41
18458488-9	2008	The hydrogel has an initial water-uptake ratio of approximately 50, decreased to 30-40 after incubation in water for 11 h depending on the thrombin concentration.	Water	107-112	coagulation factor II, thrombin	Homo sapiens	139-147
17368889-2	2008	A new water-soluble intracellular polysaccharide named as PTP, with a molecular mass of 3.7x10(4) Da, was obtained from the mycelium of Polyporus albicans (Imaz.)	Water	6-11	protein tyrosine phosphatase, receptor type, U	Mus musculus	58-61
18310926-3	2008	We have previously shown COX-2 inhibitory activity locally in the colon; e.g. in human fecal water from a group of vegetarians.	Water	93-98	prostaglandin-endoperoxide synthase 2	Homo sapiens	25-30
18249020-1	2008	As one subgroup of aquaporin, aquaglyceroporin including AQP3, 7, 9, 10 facilitates glycerol transport as well as water transport.	Water	114-119	aquaporin 3	Sus scrofa	57-61
18301292-3	2008	The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes CFTR protein that functions as cyclic AMP-dependent chloride channel allowing the passage of anions and secondarily water into the lumen of pancreatic ducts.	Water	192-197	CF transmembrane conductance regulator	Homo sapiens	4-55
18301292-3	2008	The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes CFTR protein that functions as cyclic AMP-dependent chloride channel allowing the passage of anions and secondarily water into the lumen of pancreatic ducts.	Water	192-197	CF transmembrane conductance regulator	Homo sapiens	57-61
18301292-3	2008	The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes CFTR protein that functions as cyclic AMP-dependent chloride channel allowing the passage of anions and secondarily water into the lumen of pancreatic ducts.	Water	192-197	CF transmembrane conductance regulator	Homo sapiens	76-80
18376056-2	2008	This study shows that fibril formation is hastened by the biological buffers required to support the growth of mammalian cells, but is prevented if Abeta is maintained in water.	Water	171-176	amyloid beta precursor protein	Homo sapiens	148-153
18186079-7	2008	When compared with healthy littermates, we observed a significant downregulation of the gap-junction channel connexin 43 (Cx43) the water channel aquaporin 4 (Aqp4) genes, and the astrocytic inward-rectifying potassium channel (Kir) genes Kir4.1 and Kir5.1 in hyperammonemic mice.	Water	132-137	gap junction protein, alpha 1	Mus musculus	109-120
18186079-8	2008	Aqp4, Cx43, and Kir4.1/Kir5.1 are co-localized to astrocytic end-feet at the brain vasculature, where they regulate potassium and water transport.	Water	130-135	gap junction protein, alpha 1	Mus musculus	6-10
18180041-1	2008	The interactions of transferrin (Tf) with the water soluble corrole 1 and with its gallium (1-Ga) and manganese (1-Mn) complexes were studied to establish the possible utilization of corrole-transferrin conjugates for targeting these corroles to cells that express the transferrin receptor.	Water	46-51	transferrin	Homo sapiens	20-31
18310451-6	2008	Finally, central administration of an antiserum specific to obestatin resulted in an exaggerated basal vasopressin release and an increased vasopressin response to overnight water deprivation.	Water	174-179	arginine vasopressin	Rattus norvegicus	140-151
18180041-1	2008	The interactions of transferrin (Tf) with the water soluble corrole 1 and with its gallium (1-Ga) and manganese (1-Mn) complexes were studied to establish the possible utilization of corrole-transferrin conjugates for targeting these corroles to cells that express the transferrin receptor.	Water	46-51	transferrin	Homo sapiens	33-35
18194430-11	2008	The development of nonpeptide agonists of the apelin receptor may provide new therapeutic tools for treating water retention, hyponatraemia and cardiovascular diseases.	Water	109-114	apelin	Bos taurus	46-52
19704716-1	2008	Ascorbate peroxidase (APX) is a reactive oxygen species (ROSs) scavenging enzyme involved in regulation of intracellular ROS levels by reduction of H(2)O(2) to water using ascorbate as an electron donor.	Water	160-165	peroxidase 42-like	Gossypium hirsutum	10-20
18310033-3	2008	However, mass production of biocatalyst using DBT is impractical because of its high price, low water solubility, and growth inhibition by 2-hydroxybiphenyl (2-HBP), which is the end product of the 4S pathway.	Water	96-101	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	Mus musculus	160-163
18164085-6	2008	The ckr mice, which are homozygous for the transgene insertion, but not heterozygous littermates, showed impaired PPI in the absence of any difference in acoustic startle amplitude and showed deficits in LI of conditioning of a light stimulus to footshock, measured as suppression of licking for water in water-restricted mice.	Water	296-301	chakragati	Mus musculus	4-7
18164085-6	2008	The ckr mice, which are homozygous for the transgene insertion, but not heterozygous littermates, showed impaired PPI in the absence of any difference in acoustic startle amplitude and showed deficits in LI of conditioning of a light stimulus to footshock, measured as suppression of licking for water in water-restricted mice.	Water	305-310	chakragati	Mus musculus	4-7
19083400-8	2008	Hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase.	Water	14-19	adiponectin, C1Q and collagen domain containing	Homo sapiens	163-174
19083400-10	2008	In conclusion, these results suggest that supplementation with hydrogen-rich water may have a beneficial role in prevention of T2DM and insulin resistance.	Water	77-82	insulin	Homo sapiens	136-143
17894331-6	2008	It is also found that the number of water molecules hydrating the ions is reduced as the ions enter the pore, implying that the energetic cost for detaching water molecules from a permeating ion also contributes to the free energy barriers of ion transport in AQP1.	Water	36-41	aquaporin 1 (Colton blood group)	Homo sapiens	260-264
17894331-6	2008	It is also found that the number of water molecules hydrating the ions is reduced as the ions enter the pore, implying that the energetic cost for detaching water molecules from a permeating ion also contributes to the free energy barriers of ion transport in AQP1.	Water	157-162	aquaporin 1 (Colton blood group)	Homo sapiens	260-264
18371829-5	2008	The sensor was applied to tap water, blood, and rat tail vascular (in vivo).	Water	30-35	nuclear RNA export factor 1	Rattus norvegicus	26-29
18155659-1	2008	The three-dimensional models built for the Nod26-like aquaporins all exhibit the typical alpha-helical fold of other aquaporins containing the two ar/R and NPA constriction filters along the central water channel.	Water	199-204	NLR family member X1	Homo sapiens	43-48
18155659-4	2008	However, all Nod26-like aquaporins display a bipartite distribution of electrostatic charges along the water channel with an electropositive extracellular vestibular portion followed by an electronegative cytosolic vestibular portion.	Water	103-108	NLR family member X1	Homo sapiens	13-18
18155659-5	2008	The specific transport of water, non-ionic solutes (glycerol, urea, ammoniac), ions (NH4+) and gas (NH(3)) across the Nod26-like obviously depends on the electrostatic and conformational properties of their central water channel.	Water	26-31	NLR family member X1	Homo sapiens	118-123
18155659-5	2008	The specific transport of water, non-ionic solutes (glycerol, urea, ammoniac), ions (NH4+) and gas (NH(3)) across the Nod26-like obviously depends on the electrostatic and conformational properties of their central water channel.	Water	215-220	NLR family member X1	Homo sapiens	118-123
18247601-5	2008	Molecular dynamics (MD) simulation for the cis and trans forms of NMA was also carried out for the SPC model of water.	Water	112-117	proline rich protein gene cluster	Homo sapiens	99-102
18287043-1	2008	By phosphoproteome analysis, we identified a phosphorylation site, serine 264 (pS264), in the COOH terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2).	Water	137-142	arginine vasopressin	Rattus norvegicus	115-126
17698408-9	2008	Cyclic voltammetry and LSER analyses illustrate the variation of reduction property of Co(III) by the aryl ligand and homogeneous solvation of the excited state of the complex Co(III)(en)(2)Br(RC(6)H(4)NH(2))(2+) in H(2)O/Bu(t)OH mixtures.	Water	216-221	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	87-94
17698408-9	2008	Cyclic voltammetry and LSER analyses illustrate the variation of reduction property of Co(III) by the aryl ligand and homogeneous solvation of the excited state of the complex Co(III)(en)(2)Br(RC(6)H(4)NH(2))(2+) in H(2)O/Bu(t)OH mixtures.	Water	216-221	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	176-183
18086667-9	2008	The ability of wild type and mutant clones of R67 DHFR to allow host Escherichia coli to grow in the presence of trimethoprim plus added sorbitol parallels the catalytic efficiency of the DHFR clones, indicating water content strongly correlates with the in vivo function of R67 DHFR.	Water	212-217	dihydrofolate reductase	Escherichia coli	50-54
18086667-9	2008	The ability of wild type and mutant clones of R67 DHFR to allow host Escherichia coli to grow in the presence of trimethoprim plus added sorbitol parallels the catalytic efficiency of the DHFR clones, indicating water content strongly correlates with the in vivo function of R67 DHFR.	Water	212-217	dihydrofolate reductase	Escherichia coli	188-192
18086667-9	2008	The ability of wild type and mutant clones of R67 DHFR to allow host Escherichia coli to grow in the presence of trimethoprim plus added sorbitol parallels the catalytic efficiency of the DHFR clones, indicating water content strongly correlates with the in vivo function of R67 DHFR.	Water	212-217	dihydrofolate reductase	Escherichia coli	188-192
18045581-2	2008	In this study, the protective effects of water extract of SN (SNE) against liver damage were evaluated in carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats.	Water	41-46	C-C motif chemokine ligand 4	Rattus norvegicus	128-132
17574332-0	2008	Wet oxidative method for removal of 2,4,6-trichlorophenol in water using Fe(III), Co(II), Ni(II) supported MCM41 catalysts.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
18303575-3	2008	Water intake following intracerebroventricular injection of angiotensin II at 100 pmol was inhibited significantly by coinjection of galanin at over 25 pmol, although galanin alone did not affect water intake.	Water	0-5	angiotensinogen	Rattus norvegicus	60-74
18189421-3	2008	Both dimeric and monomeric (isolated from dimer) forms of TIM are simulated in explicit water at 300 K and 1 bar to inspect any differences between the structures in terms of fluctuation dynamics and functionally important loop 6 dynamics/closure.	Water	88-93	triosephosphate isomerase 1	Homo sapiens	58-61
18341118-0	2008	Projected stream water fluxes of NO3 and total organic carbon from the Storgama headwater catchment, Norway, under climate change and reduced acid deposition.	Water	17-22	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
18174273-2	2008	Because aquaporin-8 (AQP8) seems to facilitate the canalicular osmotic water movement during hepatocyte bile formation, we studied its gene and functional expression in LPS-induced cholestasis.	Water	71-76	aquaporin 8	Rattus norvegicus	8-19
18174273-2	2008	Because aquaporin-8 (AQP8) seems to facilitate the canalicular osmotic water movement during hepatocyte bile formation, we studied its gene and functional expression in LPS-induced cholestasis.	Water	71-76	aquaporin 8	Rattus norvegicus	21-25
17574332-2	2008	In the present work, Fe(III), Co(II) and Ni(II) incorporated MCM41 mesoporous solids were used as catalysts for oxidation of 2,4,6-trichlorophenol in water with or without the oxidant, H(2)O(2).	Water	150-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
17574332-6	2008	The conversion achieved with Fe(III), Co(II) and Ni(II) incorporated MCM41 in 5h is respectively 59.4, 50.0 and 65.6% with 2,4,6-TCP:H(2)O(2) molar ratio of 1:1, and 60.2, 60.9 and 68.8% in absence of H(2)O(2).	Water	133-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
17928628-7	2008	Differentially regulated genes included several encoding proteins involved in spermatozoal maturation, water and ion channels, and beta-defensins: CRISP1, SPINLW1, FAM12B, and DEFB129 were upregulated, whereas CFTR, AQP5, KCNK4, KCNK17, SLC6A20, SLC13A3, DEFB126, and DEFB106A were downregulated.	Water	103-108	epididymal peptidase inhibitor	Homo sapiens	155-162
18365694-0	2008	Modulation of the genomic estrogen receptor pathway by water extracts of Cirsium japonicum.	Water	55-60	estrogen receptor 1	Homo sapiens	26-43
17928628-7	2008	Differentially regulated genes included several encoding proteins involved in spermatozoal maturation, water and ion channels, and beta-defensins: CRISP1, SPINLW1, FAM12B, and DEFB129 were upregulated, whereas CFTR, AQP5, KCNK4, KCNK17, SLC6A20, SLC13A3, DEFB126, and DEFB106A were downregulated.	Water	103-108	defensin beta 129	Homo sapiens	176-183
18282122-2	2008	Currently, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules, such as AQP1, or also glycerol and other small solutes.	Water	120-125	aquaporin 1 (Colton blood group)	Homo sapiens	145-149
17576056-5	2008	The particles were prepared by spraying an acidic water/DMSO solution of insulin and polymer into supercritical carbon dioxide.	Water	50-55	insulin	Homo sapiens	73-80
18174273-6	2008	Osmotic water permeability (P(f)) of canalicular membranes, measured by stopped-flow spectrophotometry, was significantly reduced (65 +/- 1 vs. 49 +/- 1 microm/s) by LPS, consistent with defective canalicular AQP8 functional expression.	Water	8-13	aquaporin 8	Rattus norvegicus	209-213
18156624-6	2008	In vivo blockade of IFN-gamma and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production.	Water	67-70	interferon gamma	Mus musculus	20-29
17984171-5	2008	Network analyses suggested that upregulated expression of chromosome 21 genes such as S100B and amyloid precursor protein activated the stress response kinase pathways, and furthermore, could be linked to upregulation of the water channel aquaporin 4 (AQP4).	Water	225-230	S100 calcium binding protein B	Homo sapiens	86-91
18055461-3	2008	Using the male reproductive tract as a model system in which water and glycerol transport are critical for the establishment of fertility, we now report a novel pathway for the regulation of aquaporin 9 (AQP9) permeability.	Water	61-66	aquaporin 9	Homo sapiens	191-202
18335805-3	2008	AQP2 is the predominant vasopressin regulated water channel of the kidney collecting duct and is essential for urinary concentration.	Water	46-51	arginine vasopressin	Homo sapiens	24-35
18055461-3	2008	Using the male reproductive tract as a model system in which water and glycerol transport are critical for the establishment of fertility, we now report a novel pathway for the regulation of aquaporin 9 (AQP9) permeability.	Water	61-66	aquaporin 9	Homo sapiens	204-208
17968524-4	2008	After AQP3 knock-down in keratinocyte cell cultures, which reduced cell membrane water and glycerol permeabilities, cell migration was slowed by more than twofold, with reduced lamellipodia formation at the leading edge of migrating cells.	Water	81-86	aquaporin 3	Mus musculus	6-10
18042646-1	2008	CONTEXT: Dual oxidase 2 (DUOX2) is the catalytic core of the H(2)O(2) generator crucial for the iodination of thyroglobulin in thyroid hormone synthesis.	Water	61-66	dual oxidase 2	Homo sapiens	9-23
18042646-1	2008	CONTEXT: Dual oxidase 2 (DUOX2) is the catalytic core of the H(2)O(2) generator crucial for the iodination of thyroglobulin in thyroid hormone synthesis.	Water	61-66	dual oxidase 2	Homo sapiens	25-30
17968524-8	2008	Our results provide evidence for involvement of AQP3-facilitated water transport in epidermal cell migration and for AQP3-facilitated glycerol transport in epidermal cell proliferation.	Water	65-70	aquaporin 3	Mus musculus	48-52
18334937-12	2008	Moreover, EGCG attenuated the reduced activation and expression of ERK, p38 MAPK, and Akt induced by H(2)O(2).	Water	101-106	mitogen-activated protein kinase 1	Homo sapiens	67-70
18088360-4	2008	beta-MSH injection on food and water intake, plasma corticosterone concentration, ingestive and non-ingestive behaviours, and hypothalamic neuronal activation using Cobb-500 chicks.	Water	31-36	proopiomelanocortin	Homo sapiens	0-8
18088360-5	2008	Chicks responded to beta-MSH-treatment with a reduction in food and water intake; however when water intake was measured independently of food intake, it was not affected.	Water	68-73	proopiomelanocortin	Homo sapiens	20-28
18088360-5	2008	Chicks responded to beta-MSH-treatment with a reduction in food and water intake; however when water intake was measured independently of food intake, it was not affected.	Water	95-100	proopiomelanocortin	Homo sapiens	20-28
17555898-2	2008	The same reaction was used for the spectrophotometric assay of TNT in soil by CRREL (Cold Regions Research &amp; Engineering Laboratory of the U.S. Army) method, also known as Jenkins" method, but the color stability was too dependent on the solution composition and the water tolerance was low, necessitating complete drying of soil samples (which may cause partial analyte decomposition) prior to analysis.	Water	271-276	chromosome 16 open reading frame 82	Homo sapiens	63-66
18334937-12	2008	Moreover, EGCG attenuated the reduced activation and expression of ERK, p38 MAPK, and Akt induced by H(2)O(2).	Water	101-106	AKT serine/threonine kinase 1	Homo sapiens	86-89
17956998-4	2008	Among the 30 transcripts with the greatest signals on the arrays were 3 water channels: aquaporin-2, aquaporin-3, and aquaporin-4, all of which have been reported to be targets for regulation by vasopressin.	Water	72-77	arginine vasopressin	Rattus norvegicus	195-206
17956998-1	2008	Vasopressin acts on the inner medullary collecting duct (IMCD) in the kidney to regulate water and urea transport.	Water	89-94	arginine vasopressin	Rattus norvegicus	0-11
18202181-2	2008	We studied the selectivity of aquaporin-1 (AQP1) and the bacterial glycerol facilitator, GlpF, for O(2), CO(2), NH(3), glycerol, urea, and water.	Water	139-144	aquaporin 1 (Colton blood group)	Homo sapiens	30-41
18248009-7	2008	This quasi-homogeneous kinetics implies that at room temperature, the surface energy of the Abeta/water interface is &gt; or =4.8 mJ/m(2), the free energy barrier to nucleation (at 25 times supersaturation) is &gt; or =1.93x10(-19) J, and the number of monomers in the nucleus is &gt; or =29.	Water	98-103	amyloid beta precursor protein	Homo sapiens	92-97
18082753-11	2008	Concentrations of the other phthalates were low (around sub-ppb) except for DBP in the water from a polycarbonate bottle at 1.72 microg L(-1).	Water	87-92	D-box binding PAR bZIP transcription factor	Homo sapiens	76-79
18052269-1	2008	The motion of water molecules in mixtures of water and d6-dimethyl sulfoxide (DMSO) has been explored through molecular dynamics (MD) simulations using the SPC/E water model (J. Chem.	Water	14-19	proline rich protein gene cluster	Homo sapiens	156-159
18817197-10	2008	Since the spring water contains high concentration of NO3, hence can not be used for drinking purposes without prior treatment.	Water	17-22	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
17890401-7	2008	Structural models of the two complexes of thrombin with TBA and with mTBA were also obtained and subjected to molecular dynamics simulations in explicit water.	Water	153-158	coagulation factor II, thrombin	Homo sapiens	42-50
18053968-1	2008	Aquaporin 9 facilitates the diffusion of water but also glycerol and monocarboxylates, known as brain energy substrates.	Water	41-46	aquaporin 9	Rattus norvegicus	0-11
20641324-3	2004	Angiotensin II also stimulates the production of aldosterone from the adrenal glands that promotes sodium and water retention.	Water	110-115	angiotensinogen	Homo sapiens	0-14
18081321-2	2008	The C-terminal region containing the major phosphorylation sites is a putative calmodulin-binding site, and calmodulin has been shown to regulate AQP0 water permeability.	Water	151-156	calmodulin 1	Homo sapiens	79-89
18081321-2	2008	The C-terminal region containing the major phosphorylation sites is a putative calmodulin-binding site, and calmodulin has been shown to regulate AQP0 water permeability.	Water	151-156	calmodulin 1	Homo sapiens	108-118
18081321-2	2008	The C-terminal region containing the major phosphorylation sites is a putative calmodulin-binding site, and calmodulin has been shown to regulate AQP0 water permeability.	Water	151-156	major intrinsic protein of lens fiber	Homo sapiens	146-150
18769038-8	2008	Moreover, inhibiting soluble guanylate cyclase (sGC) with ODQ mimicked the effect of L-NAME and abolished the effect of H(2)O(2).	Water	120-125	sarcoglycan beta	Homo sapiens	48-51
19388360-14	2008	These data provide further support that vasopressin (AVP) and V1a receptors can control water flux through astrocytic plasma membranes by regulating AQP4 expression.	Water	88-93	arginine vasopressin	Rattus norvegicus	40-51
19388361-5	2008	Administration of the vasopressin antagonist (SR49059) reduced brain water content and sodium shift following MCAo.	Water	69-74	arginine vasopressin	Rattus norvegicus	22-33
18175936-4	2008	Electrolyzed reduced water (ERW) produced near the cathode during the electrolysis of water scavenged intracellular H(2)O(2) and decreased the release of H(2)O(2) from a human lung adenocarcinoma cell line, A549, and down-regulated both VEGF transcription and protein secretion in a time-dependent manner.	Water	21-26	vascular endothelial growth factor A	Homo sapiens	237-241
18175936-4	2008	Electrolyzed reduced water (ERW) produced near the cathode during the electrolysis of water scavenged intracellular H(2)O(2) and decreased the release of H(2)O(2) from a human lung adenocarcinoma cell line, A549, and down-regulated both VEGF transcription and protein secretion in a time-dependent manner.	Water	86-91	vascular endothelial growth factor A	Homo sapiens	237-241
18055199-1	2008	Alkyl- or aryl-14H-dibenzo[a,j]xanthene derivatives are synthesized efficiently by the reaction of beta-naphthol and aliphatic and aromatic aldehydes in the presence of KAl(SO4)2 x 12 H2O (alum) under aqueous condition at 100 degrees C. Different types of aromatic and aliphatic aldehydes are used in the reaction and in all cases the products synthesized successfully.	Water	184-187	anosmin 1	Homo sapiens	169-172
19066088-10	2008	Our study showed that the increase in brain water content caused by ICH was significantly smaller in CD18 knockout mice compared with wild-type mice (p &lt; 0.05, Student t-test).	Water	44-49	integrin beta 2	Mus musculus	101-105
18078323-2	2008	Here, we show that introduction of an ultrahigh-molecular-weight poly(ethylene oxide) (UHMWPEO) into aqueous chitosan solutions remarkably enhances the formation of chitosan nanofibrous structure and leads to much lower loading of the water soluble fiber-forming aiding agent of PEO down to 5 wt % as compared to previous high PEO loadings in the electrospun chitosan nanofibers.	Water	235-240	twinkle mtDNA helicase	Homo sapiens	91-94
17239585-3	2008	It was shown that the use of OME and tap water mixture consisting of OME up to 25% volumetrically was possible for the purpose of commercial mushroom production.	Water	41-46	common wheat expressed sequence tag	Triticum aestivum	37-40
18209479-1	2008	BACKGROUND/AIMS: Aquaporin-3 (AQP3), one isoform of water channel family, has been found to be expressed in mouse oocytes.	Water	52-57	aquaporin 3	Mus musculus	17-28
18209479-1	2008	BACKGROUND/AIMS: Aquaporin-3 (AQP3), one isoform of water channel family, has been found to be expressed in mouse oocytes.	Water	52-57	aquaporin 3	Mus musculus	30-34
18209479-11	2008	CONCLUSION: AQP3 might play an important role in controlling oocyte quality and a low in vitro fertilization rate of COH mice might, in part, result from reduced AQP3 expression and water permeability in mouse oocytes.	Water	182-187	aquaporin 3	Mus musculus	12-16
18702165-0	2008	A property-matched water-soluble analogue of the benchmark ligand PPh3.	Water	19-24	caveolin 1	Homo sapiens	66-70
18563799-10	2008	Regioisomeric 1,5-diarylpyrazolines, 1,2-diarylimidazolines, and water-soluble imidazoles have been designed as novel CB1 receptor antagonist structure classes.	Water	65-70	cannabinoid receptor 1	Homo sapiens	118-121
18702165-2	2008	Of these, the trisulfonated trisbiphenylphosphane can be considered as a true water-soluble analogue of PPh(3) as the cone angle and basicity of both phosphanes are very close and result in a similar coordination mode on palladium and rhodium complexes.	Water	78-83	caveolin 1	Homo sapiens	104-110
18090672-5	2008	Medullary cyclooxygenase-2 metabolites modulate salt and water excretion, and cyclooxygenase-2 inhibitors lead to sodium and volume retention and may raise blood pressure.	Water	57-62	prostaglandin-endoperoxide synthase 2	Homo sapiens	10-26
18278747-2	2008	The lack of, or inability to appropriately respond to, AVP results in a lack of tubular reabsorption of water and urine of low specific gravity.	Water	104-109	arginine vasopressin	Homo sapiens	55-58
18401169-5	2008	We have employed both techniques to unravel the molecular machinery of vasopressin signaling, which governs water homeostasis by recruiting aquaporin-2 (AQP2) water channels after activation of the vasopressin-2 receptor by vasopressin.	Water	108-113	arginine vasopressin	Homo sapiens	71-82
18762715-1	2008	The mechanism of glycerol transport by human aquaporin 9 (hAQP9), which is a liver-specific AQP water channel and can also transport glycerol, was investigated by using the Xenopus laevis oocyte expression system.	Water	96-101	aquaporin 9	Homo sapiens	45-56
18762715-1	2008	The mechanism of glycerol transport by human aquaporin 9 (hAQP9), which is a liver-specific AQP water channel and can also transport glycerol, was investigated by using the Xenopus laevis oocyte expression system.	Water	96-101	aquaporin 9	Homo sapiens	58-63
18629448-2	2008	EAU can be induced in mice by immunization with the retinal antigen interphotoreceptor retinoid binding protein (IRBP) in complete Freund"s adjuvant (CFA) or by IRBP-pulsed mature dendritic cells, and can be driven either by a Th17 or a Th1 effector response, depending on the model.	Water	0-3	negative elongation factor complex member C/D, Th1l	Mus musculus	227-230
19109654-2	2008	The milk fatty acids are derived almost equally from two sources, the feed and the microbial activity in the rumen of the cow and the lipids in bovine milk are mainly present in globules as an oil-in-water emulsion.	Water	200-205	Weaning weight-maternal milk	Bos taurus	4-8
19109654-2	2008	The milk fatty acids are derived almost equally from two sources, the feed and the microbial activity in the rumen of the cow and the lipids in bovine milk are mainly present in globules as an oil-in-water emulsion.	Water	200-205	Weaning weight-maternal milk	Bos taurus	151-155
18441949-6	2008	It is suggested that the "Ca-rich" alkali minerals could alleviate acidity of the fog water in Beijing air.	Water	86-91	zinc finger protein, FOG family member 1	Homo sapiens	82-85
18360029-0	2008	A water-soluble fullerene vesicle alleviates angiotensin II-induced oxidative stress in human umbilical venous endothelial cells.	Water	2-7	angiotensinogen	Homo sapiens	45-59
18360029-1	2008	A water-soluble fullerene vesicle based on the Buckminsterfullerene molecule (Ph(5)C(60)K, denoted as PhK) was explored to determine its effects on anti-oxidation of human umbilical endothelial cells (HUVEC) exposed to exogenous and endogenous reactive oxygen species (ROS).	Water	2-7	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	102-105
18360029-9	2008	These observations show that the PhK water-soluble fullerene vesicle is promising as a compound controlling not only exogenous ROS, but also endogenous AII-mediated pathophysiological conditions.	Water	37-42	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	33-36
18360029-9	2008	These observations show that the PhK water-soluble fullerene vesicle is promising as a compound controlling not only exogenous ROS, but also endogenous AII-mediated pathophysiological conditions.	Water	37-42	angiotensinogen	Homo sapiens	152-155
17941896-2	2008	Recent studies indicate that the aquaporin-1 (AQP1) water channel is expressed in human and equine articular chondrocytes.	Water	52-57	aquaporin 1 (Colton blood group)	Homo sapiens	33-44
17941896-2	2008	Recent studies indicate that the aquaporin-1 (AQP1) water channel is expressed in human and equine articular chondrocytes.	Water	52-57	aquaporin 1 (Colton blood group)	Homo sapiens	46-50
17941896-8	2008	Relative plasma membrane water permeability of AQP1(+/+) chondrocytes was approximately 1.6-fold higher than that of AQP1(-/-) chondrocytes.	Water	25-30	aquaporin 1 (Colton blood group)	Homo sapiens	47-51
17941896-14	2008	The results provided direct evidence that AQP1-mediated plasma membrane water permeability plays an important role in chondrocyte migration and adhesion.	Water	72-77	aquaporin 1 (Colton blood group)	Homo sapiens	42-46
18306109-2	2008	Therefore, we sought to determine whether alpha-glucosylhesperidin (Hsp-G), which is an Hsp derivative with enhanced water-solubility, is effective on treating arthritis in both mice and humans.	Water	117-122	syndecan 2	Mus musculus	68-73
19079670-9	2008	Likewise, catalase, an enzyme that hydrolyzes peroxide to water, is significantly increased in ethanol exposed H4-IIE cells which further confirms ROS generation due to ethanol exposure.	Water	58-63	catalase	Rattus norvegicus	10-18
17298864-0	2008	Assessment of a turfgrass sod best management practice on water quality in a suburban watershed.	Water	58-63	superoxide dismutase 1	Homo sapiens	26-29
17852555-1	2008	PURPOSE: Inactivation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), alcohol dehydrogenase (ADH) and lactate dehydrogenase (LDH) by products of water radiolysis and by secondary radicals localized on haemoglobin (Hb) and human albumin (HSA) was studied.	Water	150-155	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	25-65
17852555-1	2008	PURPOSE: Inactivation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), alcohol dehydrogenase (ADH) and lactate dehydrogenase (LDH) by products of water radiolysis and by secondary radicals localized on haemoglobin (Hb) and human albumin (HSA) was studied.	Water	150-155	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	67-72
18040865-0	2008	Structure of human insulin monomer in water/acetonitrile solution.	Water	38-43	insulin	Homo sapiens	19-26
18040865-2	2008	An NMR-derived human insulin monomer structure in H2O/CD3CN, 65/35 vol%, pH 3.6 is presented and compared with the available X-ray structure of a monomer that forms part of a hexamer (Acta Crystallogr.	Water	50-53	insulin	Homo sapiens	21-28
19195551-5	2008	In the presence of calcium, however, t-SNARE vesicles interact with v-SNARE vesicles, allowing formation of calcium-phosphate bridges between the opposing bilayers, resulting in the expulsion of coordinated water at the phosphate of the phospholipid head-groups, and due to disruption of the water shell around the calcium ion, enabling lipid mixing and membrane fusion.	Water	207-212	small NF90 (ILF3) associated RNA E	Homo sapiens	39-44
18814580-8	2008	Rokko region, MM5 generally reproduced the occurrence of relatively thick fog events but tended to overestimate liquid water content (LWC) of fog (by factors of 2.2-3.3 in terms of monthly mean LWC).	Water	119-124	zinc finger protein, FOG family member 1	Homo sapiens	142-145
18401124-3	2008	We report on an unintentional drinking-water contamination event that occurred in Tel Aviv, Israel in July, 2001.	Water	39-44	ETS variant transcription factor 6	Homo sapiens	82-85
19195551-5	2008	In the presence of calcium, however, t-SNARE vesicles interact with v-SNARE vesicles, allowing formation of calcium-phosphate bridges between the opposing bilayers, resulting in the expulsion of coordinated water at the phosphate of the phospholipid head-groups, and due to disruption of the water shell around the calcium ion, enabling lipid mixing and membrane fusion.	Water	207-212	vesicle transport through interaction with t-SNAREs 1B	Homo sapiens	68-75
18446279-4	2008	As a practical example, a full simulation of the protein lysozyme in water is described step by step, including examples of necessary hardware and software, how to obtain suitable starting molecular structures, immersing it in a solvent, choosing good simulation parameters, and energy minimization.	Water	69-74	lysozyme	Homo sapiens	57-65
19195551-5	2008	In the presence of calcium, however, t-SNARE vesicles interact with v-SNARE vesicles, allowing formation of calcium-phosphate bridges between the opposing bilayers, resulting in the expulsion of coordinated water at the phosphate of the phospholipid head-groups, and due to disruption of the water shell around the calcium ion, enabling lipid mixing and membrane fusion.	Water	292-297	small NF90 (ILF3) associated RNA E	Homo sapiens	39-44
19195551-5	2008	In the presence of calcium, however, t-SNARE vesicles interact with v-SNARE vesicles, allowing formation of calcium-phosphate bridges between the opposing bilayers, resulting in the expulsion of coordinated water at the phosphate of the phospholipid head-groups, and due to disruption of the water shell around the calcium ion, enabling lipid mixing and membrane fusion.	Water	292-297	vesicle transport through interaction with t-SNAREs 1B	Homo sapiens	68-75
17959710-5	2008	The fact that the Ile6.40(420)Arg/Lys/Glu mutant receptors are highly active CAM H(1)Rs leads us to suggest that a positively charged residue, presumably the highly conserved Arg3.50 from the DRY motif, interacts in a direct or an indirect (through other side chains or/and internal water molecules) manner with the acidic Asp2.50..Asn7.49 pair for receptor activation.	Water	283-288	beta-secretase 1	Homo sapiens	323-327
18369935-7	2008	In the content-mixing assay, the water-soluble fluorophore 8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS) (pyranine) and its quencher p-Xylene-bis-pyridinium bromide (DPX) are incorporated into v-SNARE vesicles.	Water	33-38	vesicle transport through interaction with t-SNAREs 1B	Homo sapiens	208-215
17967887-1	2008	Aquaporin-3 (AQP3) is a water/glycerol-transporting protein expressed strongly at the plasma membranes of basal epidermal cells in skin.	Water	24-29	aquaporin 3	Mus musculus	0-11
17967887-1	2008	Aquaporin-3 (AQP3) is a water/glycerol-transporting protein expressed strongly at the plasma membranes of basal epidermal cells in skin.	Water	24-29	aquaporin 3	Mus musculus	13-17
18667805-4	2008	Vasopressin cells sense plasma osmolality and secrete appropriate levels of vasopressin from the neurohypophysis as needed to control water excretion; this requires sustained secretion under basal conditions and the ability to increase (or decrease) secretion should plasma osmolality change.	Water	134-139	arginine vasopressin	Homo sapiens	0-11
18667805-4	2008	Vasopressin cells sense plasma osmolality and secrete appropriate levels of vasopressin from the neurohypophysis as needed to control water excretion; this requires sustained secretion under basal conditions and the ability to increase (or decrease) secretion should plasma osmolality change.	Water	134-139	arginine vasopressin	Homo sapiens	76-87
17638023-6	2008	An insufficient function of the water-selective aquaporin 1 (AQP-1) channel may also be causative for inadequate ultrafiltration.	Water	32-37	aquaporin 1 (Colton blood group)	Homo sapiens	48-59
17638023-6	2008	An insufficient function of the water-selective aquaporin 1 (AQP-1) channel may also be causative for inadequate ultrafiltration.	Water	32-37	aquaporin 1 (Colton blood group)	Homo sapiens	61-66
18477918-8	2008	Irs was higher in children with vs. those without respiratory disease (median 0.00224 cm H2O/L/sec2, Q1-Q3 0.00180-0.00321 vs. median 0.00133 cm H2O/L/sec2, Q1-Q3 0.00072-0.00210; p &lt; .001)).	Water	89-92	isoleucyl-tRNA synthetase 1	Homo sapiens	0-3
18477918-8	2008	Irs was higher in children with vs. those without respiratory disease (median 0.00224 cm H2O/L/sec2, Q1-Q3 0.00180-0.00321 vs. median 0.00133 cm H2O/L/sec2, Q1-Q3 0.00072-0.00210; p &lt; .001)).	Water	145-148	isoleucyl-tRNA synthetase 1	Homo sapiens	0-3
18063441-0	2008	Interaction of antibacterial peptides spanning the carboxy-terminal region of human beta-defensins 1-3 with phospholipids at the air-water interface and inner membrane of E. coli.	Water	133-138	defensin beta 1	Homo sapiens	84-102
17888468-12	2008	Transgenic poplar characterized by ectopic expression of a pine cytosolic glutamine synthetase gene exhibits enhanced tolerance to water stress.	Water	131-136	glutamate-ammonia ligase	Homo sapiens	74-94
19283081-5	2008	This unwanted effect is due to the activation of PPARgamma in the mesonephric distal collecting system, where PPARgamma positively regulates sodium and water resorbtion leading to the expansion of interstitial fluid volume.	Water	152-157	peroxisome proliferator activated receptor gamma	Homo sapiens	49-58
18225945-3	2008	To address the mechanical fundamentals of nAChR gating, both conventional molecular dynamics (CMD) and steered rotation molecular dynamics (SRMD) simulations have been conducted on the cryo-electron microscopy (cryo-EM) structure of nAChR embedded in a dipalmitoylphosphatidylcholine (DPPC) bilayer and water molecules.	Water	303-308	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	233-238
19283081-5	2008	This unwanted effect is due to the activation of PPARgamma in the mesonephric distal collecting system, where PPARgamma positively regulates sodium and water resorbtion leading to the expansion of interstitial fluid volume.	Water	152-157	peroxisome proliferator activated receptor gamma	Homo sapiens	110-119
18186457-7	2008	In addition, linearity in the range 9.5-95 nM was obtained for the peptide angiotensin-II in deionized water with a correlation of estimation of 0.992 using an internal standard.	Water	103-108	angiotensinogen	Homo sapiens	75-89
17868662-3	2007	Reaction in the presence of [(18)O]water allowed us to obtain evidence about the mechanism of prop-1-enyl cleavage.	Water	35-40	PROP paired-like homeobox 1	Homo sapiens	94-100
18655905-9	2008	These results demonstrate the important role of AVP in the development of the disturbances in brain water and electrolyte balance in response to general cerebral hypoxia.	Water	100-105	arginine vasopressin	Rattus norvegicus	48-51
18655910-1	2008	In the kidney, the actions of the antidiuretic hormone arginine vasopressin (AVP) renders the collecting duct highly permeable to water.	Water	130-135	arginine vasopressin	Homo sapiens	64-75
18001111-1	2007	The development of enzyme mimics of catalase which decompose hydrogen peroxide to water and molecular oxygen according to the 2:1 stoichiometry of native catalase and in aqueous solution at pH 7 and at micromolar concentrations of the enzyme model and hydrogen peroxide is reported.	Water	82-87	catalase	Homo sapiens	36-44
17897666-0	2007	Interaction of N-nitrosodiethylamine/bovine serum albumin complexes with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine monolayers at the air-water interface.	Water	139-144	albumin	Homo sapiens	44-57
17897666-1	2007	We report the effect of N-nitrosodiethylamine (NDA) on the interaction between bovine serum albumin (BSA) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine monolayers (DPPC) at the air-water interface.	Water	183-188	albumin	Homo sapiens	86-99
17369110-6	2007	In the airways, though AQP3 and AQP4 facilitate osmotic water transport, their deletion does not impair airway hydration, regulation of airway surface liquid, or fluid absorption.	Water	56-61	aquaporin 3	Mus musculus	23-27
17997562-2	2007	The system comprising substrate, silane, and initiator (ACCN) mixed in aqueous medium at 100 degrees C worked well for both hydrophilic and hydrophobic substrates, with the only variation that an amphiphilic thiol was also needed in case of the water-soluble compounds.	Water	245-250	acid sensing ion channel subunit 2	Homo sapiens	56-60
17826805-5	2007	Under the discrimination task, the wv/wv mice, unlike the controls, obtained saccharin over tap water at the level of chance.	Water	96-101	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	92-95
18086774-0	2007	Adduction of human p53 gene by fecal water: an in vitro biomarker of mutagenesis in the human large bowel.	Water	37-42	tumor protein p53	Homo sapiens	19-22
18057610-1	2007	The title compound, [Co(C7H6NO2)2(H2O)4] x 4 H2O, contains a Co(II) ion lying on a crystallographic inversion centre.	Water	34-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18057610-2	2007	The Co(II) ion is octahedrally coordinated by two 6-methylpyridine-3-carboxylate ligands in axial positions [Co-O = 2.0621 (9) A] and by four water molecules in the equatorial plane [Co-O = 2.1169 (9) and 2.1223 (11) A].	Water	142-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
17901165-12	2007	H(2)O(2) generated by NADPH oxidase participates in a signal transduction pathway that maintains the GB tonic contraction by activating PAF, p38, and cPLA(2) to generate prostaglandins.	Water	0-5	mitogen-activated protein kinase 14	Homo sapiens	141-144
17957752-2	2007	AQP9 is a major apical water channel that is expressed throughout the efferent ducts, epididymis, and vas deferens, as well as in other regions of the human and rodent male reproductive tract.	Water	23-28	aquaporin 9	Homo sapiens	0-4
18059526-1	2007	Water channels AQP7 and AQP8 may be involved in transcellular water movement in the small intestine.	Water	62-67	aquaporin 8	Rattus norvegicus	24-28
18059526-8	2007	Our results indicate that AQP7 and AQP8 may play a role in water movement via the apical domain of small intestine epithelial cells.	Water	59-64	aquaporin 8	Rattus norvegicus	35-39
18059526-9	2007	AQP8 may contribute to the water-imbalance-related clinical symptoms apparent after ingestion of high doses of Hg2+ and Cu2+.	Water	27-32	aquaporin 8	Rattus norvegicus	0-4
18086774-1	2007	A polymerase arrest assay was designed to determine sites of adduction in the human p53 gene induced by incubation with fecal water.	Water	126-131	tumor protein p53	Homo sapiens	84-87
18086774-2	2007	Significant formation of adducts was observed on p53 DNA after a 2-h incubation in fecal water from 10 of 17 samples studied.	Water	89-94	tumor protein p53	Homo sapiens	49-52
18367709-1	2007	Congestive heart failure (CHF) is a clinical syndrome that features a failing heart together with signs and symptoms arising from renal retention of salt and water, mediated by attendant neurohormonal activation, and which prominently includes the renin-angiotensin-aldosterone system.	Water	158-163	renin	Homo sapiens	248-253
18220528-10	2007	The cytotoxicity of each peptide was slightly enhanced by the progressive maintenance of Abeta(1-42) and RAGE(23-54) in water over 3 weeks prior to the assay.	Water	120-125	advanced glycosylation end product-specific receptor	Rattus norvegicus	105-109
18199991-2	2007	METHODS: BC1 water solution was administered per os to mice bearing ascite or solid form of Ehrlich"s carcinoma.	Water	13-18	brain cytoplasmic RNA 1	Mus musculus	9-12
17492487-1	2007	Water with high nitrate concentration (NO(3) (-)) is unfit for human consumption, especially when its concentration exceeded the threshold limit (50 mg/l) recommended by the health authorities such as the World Health Organization (WHO).	Water	0-5	NBL1, DAN family BMP antagonist	Homo sapiens	39-44
17574243-10	2007	In conclusion, domestic tap water may constitute a source of Acanthamoeba contamination of CLSC, and most isolates from CLSC and domestic tap water appear to be potentially keratopathogenic.	Water	28-33	SEC14 like lipid binding 2	Homo sapiens	24-27
17574243-10	2007	In conclusion, domestic tap water may constitute a source of Acanthamoeba contamination of CLSC, and most isolates from CLSC and domestic tap water appear to be potentially keratopathogenic.	Water	142-147	SEC14 like lipid binding 2	Homo sapiens	138-141
18213973-2	2007	In this study we used the delta15N-NO3 signature in a watershed dominated by agriculture as an integrating marker to trace (1) the effects of the land cover and agricultural practices on stream-water N concentration in the upstream area of the hydrographic network, (2) influence of the in-stream processes on the NO3-N loads at the reach scale (100 m and 1000 m long), and (3) changes in delta15N-NO3 signature with increasing stream order (from first to third order).	Water	54-59	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
18213973-2	2007	In this study we used the delta15N-NO3 signature in a watershed dominated by agriculture as an integrating marker to trace (1) the effects of the land cover and agricultural practices on stream-water N concentration in the upstream area of the hydrographic network, (2) influence of the in-stream processes on the NO3-N loads at the reach scale (100 m and 1000 m long), and (3) changes in delta15N-NO3 signature with increasing stream order (from first to third order).	Water	54-59	NBL1, DAN family BMP antagonist	Homo sapiens	314-317
18213973-2	2007	In this study we used the delta15N-NO3 signature in a watershed dominated by agriculture as an integrating marker to trace (1) the effects of the land cover and agricultural practices on stream-water N concentration in the upstream area of the hydrographic network, (2) influence of the in-stream processes on the NO3-N loads at the reach scale (100 m and 1000 m long), and (3) changes in delta15N-NO3 signature with increasing stream order (from first to third order).	Water	54-59	NBL1, DAN family BMP antagonist	Homo sapiens	314-317
18055829-4	2007	Visual acuity was also measured by using the Visual Water Task in AAV-CNTF-injected animals.	Water	52-57	ciliary neurotrophic factor	Rattus norvegicus	70-74
17960163-5	2007	Smad7 expression was induced by doxycycline in drinking water.	Water	56-61	SMAD family member 7	Rattus norvegicus	0-5
17920625-8	2007	We describe the supramolecular assembly and the conformational state of AQP0 in junctional microdomains, where a mixture of truncated junctional and full-length water channel AQP0 form square arrays.	Water	161-166	major intrinsic protein of lens fiber	Homo sapiens	72-76
17869130-7	2007	While both proteins are involved in cell adhesion, AQP0 is a specific water channel whereas connexons form cell-cell communication channels with broad substrate specificity.	Water	70-75	major intrinsic protein of lens fiber	Homo sapiens	51-55
17972915-6	2007	Erv1 also utilized molecular oxygen as an electron acceptor to generate hydrogen peroxide, which is subsequently reduced to water by cytochrome c peroxidase (Ccp1).	Water	124-129	cytochrome c, somatic	Homo sapiens	133-145
17664179-1	2007	BACKGROUND: Aquaporin-1 (AQP-1) dysfunction is one of the valid theories for decreased free water transport (FWT) in long-term peritoneal dialysis (PD) ultrafiltration failure (UFF).	Water	92-97	aquaporin 1 (Colton blood group)	Homo sapiens	12-23
17664179-1	2007	BACKGROUND: Aquaporin-1 (AQP-1) dysfunction is one of the valid theories for decreased free water transport (FWT) in long-term peritoneal dialysis (PD) ultrafiltration failure (UFF).	Water	92-97	aquaporin 1 (Colton blood group)	Homo sapiens	25-30
17920625-8	2007	We describe the supramolecular assembly and the conformational state of AQP0 in junctional microdomains, where a mixture of truncated junctional and full-length water channel AQP0 form square arrays.	Water	161-166	major intrinsic protein of lens fiber	Homo sapiens	175-179
18075107-8	2007	This study suggests that the photolysis of NO3- and Fe-Cl complex may contribute significantly to Cr(VI) reduction in surface water that receives electroplating wastewater containing high levels of NO3-, Cl-, and Fe-(III).	Water	126-131	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
18075107-8	2007	This study suggests that the photolysis of NO3- and Fe-Cl complex may contribute significantly to Cr(VI) reduction in surface water that receives electroplating wastewater containing high levels of NO3-, Cl-, and Fe-(III).	Water	126-131	NBL1, DAN family BMP antagonist	Homo sapiens	198-201
17940969-6	2007	Interestingly, we observed an early increase in water permeability in response to TNF- alpha /H2O2 that was not due to an opening of the interendothelial junctions.	Water	48-53	tumor necrosis factor	Homo sapiens	82-92
17937480-5	2007	MRI parameters (T2, T1, and apparent diffusion coefficient) indicated that systems with fibrinogen and thrombin (FT and MEFT) presented a structure with many and large pores, bulk water, and higher translational motion of water.	Water	180-185	coagulation factor II, thrombin	Homo sapiens	103-111
17937480-5	2007	MRI parameters (T2, T1, and apparent diffusion coefficient) indicated that systems with fibrinogen and thrombin (FT and MEFT) presented a structure with many and large pores, bulk water, and higher translational motion of water.	Water	222-227	fibrinogen beta chain	Homo sapiens	88-98
17937480-5	2007	MRI parameters (T2, T1, and apparent diffusion coefficient) indicated that systems with fibrinogen and thrombin (FT and MEFT) presented a structure with many and large pores, bulk water, and higher translational motion of water.	Water	180-185	fibrinogen beta chain	Homo sapiens	88-98
17937480-5	2007	MRI parameters (T2, T1, and apparent diffusion coefficient) indicated that systems with fibrinogen and thrombin (FT and MEFT) presented a structure with many and large pores, bulk water, and higher translational motion of water.	Water	222-227	coagulation factor II, thrombin	Homo sapiens	103-111
17944488-1	2007	Phospholipase A2 (PLA2) enzymes act at the membrane-water interface to access their phospholipid substrate from the membrane.	Water	52-57	phospholipase A2 group IB	Homo sapiens	0-16
17944488-1	2007	Phospholipase A2 (PLA2) enzymes act at the membrane-water interface to access their phospholipid substrate from the membrane.	Water	52-57	phospholipase A2 group IB	Homo sapiens	18-22
17675353-9	2007	On the other hand, the intramolecular Abeta beta-strand-loop-beta-strand U-shaped motif creates a hydrophobic cavity with a diameter of 6-7 A, allowing water molecules and ions to conduct through.	Water	152-157	amyloid beta precursor protein	Homo sapiens	38-43
17854772-5	2007	Moreover, the cytosolic caspase 3 was found to be activated by H(2)O(2), and the extent of the activation correlated well with the susceptibility of the oxidized erythrocytes to the macrophage recognition.	Water	63-68	caspase 3	Homo sapiens	24-33
17996709-4	2007	We find that while unacylated tRNA stimulates release in a nondiscriminating manner, RF1 is very specific for water.	Water	110-115	mitochondrial translation release factor 1	Homo sapiens	85-88
17629970-2	2007	Angiotensin II and osmotic signals are suggested to stimulate meal-induced water intake.	Water	75-80	angiotensinogen	Rattus norvegicus	0-14
17870091-2	2007	Within the UDG superfamily, a fifth UDG family lacks a polar residue in the active-site motif, which mediates the hydrolysis of the glycosidic bond by activation of a water molecule in UDG families 1-4.	Water	167-172	uracil-DNA glycosylase	Thermus thermophilus HB8	11-14
17870091-2	2007	Within the UDG superfamily, a fifth UDG family lacks a polar residue in the active-site motif, which mediates the hydrolysis of the glycosidic bond by activation of a water molecule in UDG families 1-4.	Water	167-172	uracil-DNA glycosylase	Thermus thermophilus HB8	36-39
17870091-2	2007	Within the UDG superfamily, a fifth UDG family lacks a polar residue in the active-site motif, which mediates the hydrolysis of the glycosidic bond by activation of a water molecule in UDG families 1-4.	Water	167-172	uracil-DNA glycosylase	Thermus thermophilus HB8	36-39
17629970-1	2007	alpha2-Adrenoceptor activation with moxonidine (alpha2-adrenergic/imidazoline receptor agonist) into the lateral parabrachial nucleus (LPBN) enhances angiotensin II/hypovolaemia-induced sodium intake and drives cell dehydrated rats to ingest hypertonic sodium solution besides water.	Water	277-282	angiotensinogen	Rattus norvegicus	150-164
17686515-8	2007	Trending towards characterization of the molecules involved, it appears that cathepsin K inhibitors remain in different nacre water-soluble organic matrix subfractions, composed of low molecular weight molecules.	Water	126-131	cathepsin K	Bos taurus	77-88
18080870-2	2007	The authors studied the role of the antioxidant enzyme, human glutathione-S-transferase A4-4 (hGSTA4-4), in regulating expression of major molecules of tight junction in vascular endothelial cells under oxidative stress induced by H(2)O(2).	Water	231-236	glutathione S-transferase alpha 4	Homo sapiens	62-92
17662339-9	2007	The concentrations of the metabolites DP and PDP are even higher in the purified water than in the raw water caused by their formation during degradation of phenazone and propyphenazone.	Water	81-86	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	45-48
17662339-9	2007	The concentrations of the metabolites DP and PDP are even higher in the purified water than in the raw water caused by their formation during degradation of phenazone and propyphenazone.	Water	103-108	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	45-48
17582460-0	2007	Determination of benzene, toluene, ethylbenzene, xylenes in water at sub-ng l-1 levels by solid-phase microextraction coupled to cryo-trap gas chromatography-mass spectrometry.	Water	60-65	immunoglobulin kappa variable 1-16	Homo sapiens	76-79
18080870-2	2007	The authors studied the role of the antioxidant enzyme, human glutathione-S-transferase A4-4 (hGSTA4-4), in regulating expression of major molecules of tight junction in vascular endothelial cells under oxidative stress induced by H(2)O(2).	Water	231-236	glutathione S-transferase alpha 4	Homo sapiens	94-102
17662298-1	2007	Batch and column tests were performed utilizing natural siderite to remove As(V) and As(III) from water.	Water	98-103	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	75-80
17942963-1	2007	In mammalian kidneys, aquaporin-1 is responsible for water reabsorption along the proximal tubule and is also thought to be involved in the concentration of urine that occurs in the medulla.	Water	53-58	aquaporin 1 (Colton blood group)	Homo sapiens	22-33
17619185-5	2007	A beta-sheet contribution of almost 100% is detected at the air-water interface.	Water	64-69	amyloid beta precursor protein	Homo sapiens	0-6
17575258-0	2007	Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption.	Water	91-96	purinergic receptor P2Y, G-protein coupled 2	Mus musculus	13-17
17575258-5	2007	The results thus identify a previously unrecognized role for P2Y2 receptors in blood pressure regulation that is linked to an inhibitory influence on renal Na+ and water reabsorption.	Water	164-169	purinergic receptor P2Y, G-protein coupled 2	Mus musculus	61-65
18299711-2	2007	A single injection of LPS caused an elevation of IL-10 in serum from GF, LPS-GF (germfree mice given drinking water containing LPS) and CV mice.	Water	110-115	interleukin 10	Mus musculus	49-54
17709401-1	2007	Tumor necrosis factor-alpha (TNF-alpha)-activated neutrophils phagocytose and eliminate bacteria by using such oxidants as hydrogen peroxide (H(2)O(2)) and hypochlorous acid (HOCl), which is produced from H(2)O(2) by myeloperoxidase (MPO).	Water	142-147	tumor necrosis factor	Homo sapiens	0-27
17938229-0	2007	Zinc modulation of water permeability reveals that aquaporin 0 functions as a cooperative tetramer.	Water	19-24	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	51-62
17938229-1	2007	We previously showed that the water permeability of AQP0, the water channel of the lens, increases with acid pH and that His40 is required (Nemeth-Cahalan, K.L., and J.E.	Water	30-35	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	52-56
17938229-1	2007	We previously showed that the water permeability of AQP0, the water channel of the lens, increases with acid pH and that His40 is required (Nemeth-Cahalan, K.L., and J.E.	Water	62-67	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	52-56
17938229-11	2007	We have now investigated the effect of zinc (and other transition metals) on the water permeability of AQP0 expressed in Xenopus oocytes and determined the amino acid residues that facilitate zinc modulation.	Water	81-86	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	103-107
17938229-12	2007	Zinc (1 mM) increased AQP0 water permeability by a factor of two and prevented any additional increase induced by acid pH.	Water	27-32	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	22-26
17938229-14	2007	Nickel, but not copper, had the same effect on AQP0 water permeability as zinc.	Water	52-57	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	47-51
17938229-16	2007	His40 and His122 are necessary for zinc modulation of AQP0 water permeability, implying structural constraints for zinc binding and functional modulation.	Water	59-64	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	54-58
17709401-1	2007	Tumor necrosis factor-alpha (TNF-alpha)-activated neutrophils phagocytose and eliminate bacteria by using such oxidants as hydrogen peroxide (H(2)O(2)) and hypochlorous acid (HOCl), which is produced from H(2)O(2) by myeloperoxidase (MPO).	Water	142-147	tumor necrosis factor	Homo sapiens	29-38
17709401-1	2007	Tumor necrosis factor-alpha (TNF-alpha)-activated neutrophils phagocytose and eliminate bacteria by using such oxidants as hydrogen peroxide (H(2)O(2)) and hypochlorous acid (HOCl), which is produced from H(2)O(2) by myeloperoxidase (MPO).	Water	205-210	tumor necrosis factor	Homo sapiens	0-27
17709401-1	2007	Tumor necrosis factor-alpha (TNF-alpha)-activated neutrophils phagocytose and eliminate bacteria by using such oxidants as hydrogen peroxide (H(2)O(2)) and hypochlorous acid (HOCl), which is produced from H(2)O(2) by myeloperoxidase (MPO).	Water	205-210	tumor necrosis factor	Homo sapiens	29-38
17847018-1	2007	The present work is a combined structural study, using Nuclear Magnetic Resonance (NMR) and Molecular Dynamics(MD), of the amidated and the free acid forms of substance P in water and methanol.	Water	174-179	tachykinin precursor 1	Homo sapiens	159-170
17914811-6	2007	31Palpha-31Palpha EXSY cross-peaks indicate that the fac-[Re(CO)3(H2O)({Palpha,Pbeta}MDP)]- isomers interchange slowly on the NMR time scale, with an average k approximately equal to 0.8 s(-1) at 32 degrees C; the EXSY cross-peaks could arise from chirality changes at only Re(I) or at only Palpha.	Water	66-69	FA complementation group C	Homo sapiens	53-56
17973055-9	2007	CONCLUSIONS: Use of continuous infusion of regular insulin associated with adequate water and electrolyte replacement using isotonic solutions, besides being an effective treatment for DKA, preserves plasma osmolarity and prevents cerebral edema.	Water	84-89	insulin	Homo sapiens	51-58
17869538-5	2007	Water channel activity of this purified hAQP1 was verified by reconstitution into proteoliposomes and performing stopped-flow vesicle shrinkage measurements.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	40-45
17704956-1	2007	Accurate potential energy surfaces for the OH + CH2F2 --&gt; H2O + CHF2 reaction are constructed using hybrid and hybrid meta density functional theory methods (mPW1PW91, B1B95, and mPW1B95) with specific reaction parameters in conjunction with the 6-31 + G(d,p) basis set.	Water	61-64	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	67-71
17978560-4	2007	Fluorescence and (13)C-NMR measurements revealed that apoA-I recognizes headgroup separation (hydrated space) between phospholipid molecules and displaces water molecules from the surface when it binds.	Water	155-160	apolipoprotein A1	Homo sapiens	54-60
17915945-0	2007	The N-terminal (1-44) and C-terminal (198-243) peptides of apolipoprotein A-I behave differently at the triolein/water interface.	Water	113-118	apolipoprotein A1	Homo sapiens	59-77
17915945-2	2007	We reported that apoA-I is conformationally flexible at the triolein/water (TO/W) interface, partially desorbing at low surface pressure (Pi) but totally desorbing at Pi &gt; 19 mN/m.	Water	69-74	apolipoprotein A1	Homo sapiens	17-23
17914811-7	2007	Guanosine 5"-diphosphate (5"-GDP), with a ribose moiety and a Re(I)-binding base, formed both possible diastereomers (RRe and SRe) of the fac-[Re(CO)3(H2O)({N7,Pbeta}GDP)]- macrochelate, with one slightly more abundant diastereomer suggested to be RRe by Mn2+ ion 1H NMR signal line-broadening combined with distances from molecular models.	Water	151-154	FA complementation group C	Homo sapiens	138-141
17914811-10	2007	The similarity of the rate constants for interchange of fac-[Re(CO)3(H2O)({Palpha,Pbeta}MDP)]- and fac-[Re(CO)3(H2O)({N7,Pbeta}GDP)]- adducts suggest strongly that interchange of Pbeta and H2O coordination positions accounts for the EXSY cross-peaks present in the spectra of all adducts.	Water	69-72	FA complementation group C	Homo sapiens	56-59
17914811-10	2007	The similarity of the rate constants for interchange of fac-[Re(CO)3(H2O)({Palpha,Pbeta}MDP)]- and fac-[Re(CO)3(H2O)({N7,Pbeta}GDP)]- adducts suggest strongly that interchange of Pbeta and H2O coordination positions accounts for the EXSY cross-peaks present in the spectra of all adducts.	Water	112-115	FA complementation group C	Homo sapiens	99-102
17914811-10	2007	The similarity of the rate constants for interchange of fac-[Re(CO)3(H2O)({Palpha,Pbeta}MDP)]- and fac-[Re(CO)3(H2O)({N7,Pbeta}GDP)]- adducts suggest strongly that interchange of Pbeta and H2O coordination positions accounts for the EXSY cross-peaks present in the spectra of all adducts.	Water	112-115	FA complementation group C	Homo sapiens	99-102
17900114-1	2007	N,N"-Disubstituted imidazolium carboxylates, readily synthetically available, isolable, air- and water-stable reagents, efficiently transfer N-heterocyclic carbene (NHC) groups to Rh, Ir, Ru, Pt, and Pd, to give novel NHC complexes, e.g., [Pd(NHC)3OAc]OAc and [Pt(NHC)3Cl]Cl (NHC = 1,3-dimethyl imidazol-2-ylidene).	Water	97-102	high mobility group nucleosomal binding domain 4	Homo sapiens	141-163
17875311-0	2007	Effect of the surface coverage of endcapped C18-silica on the excess adsorption isotherms of commonly used organic solvents from water in reversed phase liquid chromatography.	Water	129-134	Bardet-Biedl syndrome 9	Homo sapiens	44-47
17900114-1	2007	N,N"-Disubstituted imidazolium carboxylates, readily synthetically available, isolable, air- and water-stable reagents, efficiently transfer N-heterocyclic carbene (NHC) groups to Rh, Ir, Ru, Pt, and Pd, to give novel NHC complexes, e.g., [Pd(NHC)3OAc]OAc and [Pt(NHC)3Cl]Cl (NHC = 1,3-dimethyl imidazol-2-ylidene).	Water	97-102	high mobility group nucleosomal binding domain 4	Homo sapiens	218-221
17900114-1	2007	N,N"-Disubstituted imidazolium carboxylates, readily synthetically available, isolable, air- and water-stable reagents, efficiently transfer N-heterocyclic carbene (NHC) groups to Rh, Ir, Ru, Pt, and Pd, to give novel NHC complexes, e.g., [Pd(NHC)3OAc]OAc and [Pt(NHC)3Cl]Cl (NHC = 1,3-dimethyl imidazol-2-ylidene).	Water	97-102	high mobility group nucleosomal binding domain 4	Homo sapiens	218-221
17900114-1	2007	N,N"-Disubstituted imidazolium carboxylates, readily synthetically available, isolable, air- and water-stable reagents, efficiently transfer N-heterocyclic carbene (NHC) groups to Rh, Ir, Ru, Pt, and Pd, to give novel NHC complexes, e.g., [Pd(NHC)3OAc]OAc and [Pt(NHC)3Cl]Cl (NHC = 1,3-dimethyl imidazol-2-ylidene).	Water	97-102	high mobility group nucleosomal binding domain 4	Homo sapiens	218-221
17900114-1	2007	N,N"-Disubstituted imidazolium carboxylates, readily synthetically available, isolable, air- and water-stable reagents, efficiently transfer N-heterocyclic carbene (NHC) groups to Rh, Ir, Ru, Pt, and Pd, to give novel NHC complexes, e.g., [Pd(NHC)3OAc]OAc and [Pt(NHC)3Cl]Cl (NHC = 1,3-dimethyl imidazol-2-ylidene).	Water	97-102	high mobility group nucleosomal binding domain 4	Homo sapiens	165-168
17900114-1	2007	N,N"-Disubstituted imidazolium carboxylates, readily synthetically available, isolable, air- and water-stable reagents, efficiently transfer N-heterocyclic carbene (NHC) groups to Rh, Ir, Ru, Pt, and Pd, to give novel NHC complexes, e.g., [Pd(NHC)3OAc]OAc and [Pt(NHC)3Cl]Cl (NHC = 1,3-dimethyl imidazol-2-ylidene).	Water	97-102	high mobility group nucleosomal binding domain 4	Homo sapiens	218-221
17909648-1	2007	The water-soluble haem-containing peptides obtained by proteolytic digestion of cytochrome c, the microperoxidases, have been used to explore aspects of the chemistry of iron porphyrins, and as mimics for some reactions catalysed by the haemoproteins, including the reactions catalysed by the peroxidases and the cytochromes P450.	Water	4-9	cytochrome c, somatic	Homo sapiens	80-92
17887785-1	2007	With use of a time-dependent perturbation theory, vibrational energy relaxation (VER) of isotopically labeled amide I modes in cytochrome c solvated with water is investigated.	Water	154-159	cytochrome c, somatic	Homo sapiens	127-139
17825479-1	2007	In mammals, apelin and its G protein-coupled receptor, APJ, regulate blood pressure, intake of food and water, and cardiac contractility.	Water	104-109	apelin	Homo sapiens	12-18
17940053-0	2007	MAL decreases the internalization of the aquaporin-2 water channel.	Water	53-58	mal, T cell differentiation protein	Homo sapiens	0-3
17644162-3	2007	The objective was to screen surface water samples for estrogenic activity using vitellogenin (Vtg) mRNA quantification in livers of juvenile rainbow trout by real-time reverse transcriptase polymerase chain reaction (Q-RT PCR).	Water	36-41	LOC100136735	Oncorhynchus mykiss	80-92
17644162-3	2007	The objective was to screen surface water samples for estrogenic activity using vitellogenin (Vtg) mRNA quantification in livers of juvenile rainbow trout by real-time reverse transcriptase polymerase chain reaction (Q-RT PCR).	Water	36-41	LOC100136735	Oncorhynchus mykiss	94-97
17644162-4	2007	Vtg mRNA analysis of livers from fish exposed to 113 ambient water samples collected from surface waters in California"s Central Valley and northern area indicated that six samples (5% of total) may have contained EEDCs.	Water	61-66	LOC100136735	Oncorhynchus mykiss	0-3
17824692-1	2007	The three-dimensional distribution function theory of molecular liquids is applied to lysozyme in mixtures of water and noble gases.	Water	110-115	lysozyme	Homo sapiens	86-94
17699162-4	2007	Fluorescence measurements with defined proOmpA-DHFR translocation intermediates indicate mostly a water-exposed environment with a hydrophobic region in the center of the channel.	Water	98-103	dihydrofolate reductase	Escherichia coli	47-51
17935427-1	2007	Results illustrating the effects of using explicit summation terms for the r(-6) dispersion term on the interfacial properties of a Lennard-Jones fluid and SPC/E water are presented.	Water	162-167	proline rich protein gene cluster	Homo sapiens	156-159
17935427-3	2007	Simulations of SPC/E water demonstrate that the long-range dispersion forces are of secondary importance to the Coulombic forces.	Water	21-26	proline rich protein gene cluster	Homo sapiens	15-18
17824629-4	2007	The retention of initial wetting behavior in water was enhanced with higher ratios of 3FOx:BrOx that corresponds to increasing fluorous character.	Water	45-50	BRO1 domain and CAAX motif containing	Homo sapiens	91-95
17922627-4	2007	The peptide hormone arginine vasopressin vasoconstricts at the V(1A) receptor and promotes water reabsorption via the V(2) receptor in the renal collecting duct by inserting aquaporin-2 water channels into the luminal membrane.	Water	91-96	arginine vasopressin	Homo sapiens	29-40
17626156-1	2007	In renal epithelia, vasopressin influences salt and water transport, chiefly via vasopressin V(2) receptors (V(2)Rs) linked to adenylyl cyclase.	Water	52-57	arginine vasopressin	Rattus norvegicus	20-31
18007550-7	2007	Recently, agent that interfere with the renal effects of vasopressin by inhibiting water reabsorption in collecting ducts and producing free water diuresis have been used.	Water	83-88	arginine vasopressin	Homo sapiens	57-68
18007550-7	2007	Recently, agent that interfere with the renal effects of vasopressin by inhibiting water reabsorption in collecting ducts and producing free water diuresis have been used.	Water	141-146	arginine vasopressin	Homo sapiens	57-68
17718500-2	2007	We have found that a calix[6]areneacetic acid derivative forms a supramolecular complex with urea-denatured cytochrome c at the oil-water interface, which enables quantitative transfer of the protein from an 8 M urea aqueous solution into an organic phase through a proton-exchange mechanism.	Water	132-137	cytochrome c, somatic	Homo sapiens	108-120
17294279-3	2007	pH of fog water samples ranged between 7.0 and 7.6 with a volume weighted mean of 7.2, indicating its alkaline characteristic.	Water	10-15	zinc finger protein, FOG family member 1	Homo sapiens	6-9
17850128-3	2007	When expressed in a form scaled by the critical properties, the values of the coefficients for SPC water are observed to greatly exceed the magnitude of corresponding coefficients for the simple Lennard-Jones model.	Water	99-104	proline rich protein gene cluster	Homo sapiens	95-98
17850128-8	2007	For example, the sixth-order virial equation of state for SPC/E water predicts the 673 K isotherm within 8% of published molecular simulation values up to a density of 9 mol/L (roughly half the critical density of SPC/E water).	Water	64-69	proline rich protein gene cluster	Homo sapiens	58-61
17850128-8	2007	For example, the sixth-order virial equation of state for SPC/E water predicts the 673 K isotherm within 8% of published molecular simulation values up to a density of 9 mol/L (roughly half the critical density of SPC/E water).	Water	220-225	proline rich protein gene cluster	Homo sapiens	58-61
17662236-2	2007	Specifically, LL-37 induces a peptide-associated quasi-interdigitated phase in negatively charged phosphatidylglycerol (PG) model membranes, where the hydrocarbon chains are shielded from water by the peptide.	Water	188-193	cathelicidin antimicrobial peptide	Homo sapiens	14-19
17643961-7	2007	PKB activity was also upregulated in SHIP2 -/- cells as compared to +/+ cells in response to H(2)O(2).	Water	93-98	inositol polyphosphate phosphatase-like 1	Mus musculus	37-42
17618150-6	2007	AQP1 may have a major osmoregulatory role in water transport in kidney and gut in SW-acclimated fish, whereas AQP3 could be implicated in gill water transport in FW-acclimated fish.	Water	45-50	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
17294279-5	2007	The ratios of Mg(2+)/Ca(2+) and Na(+)/Ca(2+) in fog water indicates that 50-75% of fog water samples correspond to the respective ratios in local soil.	Water	52-57	zinc finger protein, FOG family member 1	Homo sapiens	48-51
17294279-5	2007	The ratios of Mg(2+)/Ca(2+) and Na(+)/Ca(2+) in fog water indicates that 50-75% of fog water samples correspond to the respective ratios in local soil.	Water	52-57	zinc finger protein, FOG family member 1	Homo sapiens	83-86
17294279-8	2007	Fog water and atmospheric alkalinity were also computed and were found to be 873 and 903 neqm(-3), respectively.	Water	4-9	zinc finger protein, FOG family member 1	Homo sapiens	0-3
17294279-10	2007	The study also shows that the alkaline nature of fog water is due to dissolution of ammonia gas and partly due to interaction of fog water with soil derived aerosols.	Water	53-58	zinc finger protein, FOG family member 1	Homo sapiens	49-52
17294279-10	2007	The study also shows that the alkaline nature of fog water is due to dissolution of ammonia gas and partly due to interaction of fog water with soil derived aerosols.	Water	53-58	zinc finger protein, FOG family member 1	Homo sapiens	129-132
17294279-10	2007	The study also shows that the alkaline nature of fog water is due to dissolution of ammonia gas and partly due to interaction of fog water with soil derived aerosols.	Water	133-138	zinc finger protein, FOG family member 1	Homo sapiens	49-52
17294279-10	2007	The study also shows that the alkaline nature of fog water is due to dissolution of ammonia gas and partly due to interaction of fog water with soil derived aerosols.	Water	133-138	zinc finger protein, FOG family member 1	Homo sapiens	129-132
17922627-4	2007	The peptide hormone arginine vasopressin vasoconstricts at the V(1A) receptor and promotes water reabsorption via the V(2) receptor in the renal collecting duct by inserting aquaporin-2 water channels into the luminal membrane.	Water	186-191	arginine vasopressin	Homo sapiens	29-40
17385225-4	2007	The water contact angle oscillated between the odd CS and the even bFGF layers, demonstrating the alternating change of the surface chemistry.	Water	4-9	fibroblast growth factor 2	Homo sapiens	67-71
17560155-1	2007	For decades, growth hormone (GH) has been known to influence electrolyte and water handling in humans and animals.	Water	77-82	growth hormone 1	Homo sapiens	13-27
17560155-1	2007	For decades, growth hormone (GH) has been known to influence electrolyte and water handling in humans and animals.	Water	77-82	growth hormone 1	Homo sapiens	29-31
17560155-3	2007	This review will examine the existing literature on renal electrolyte and water handling following acute and chronic GH-exposure.	Water	74-79	growth hormone 1	Homo sapiens	117-119
17560155-5	2007	Acute application of GH results in a reduced urinary electrolyte and water excretion, whereas the chronic effects of GH are more diverse, as this state likely represents a complex mixture of primary and secondary actions of GH as well as compensatory mechanisms.	Water	69-74	growth hormone 1	Homo sapiens	21-23
17560155-7	2007	We recently described a possible mechanism by which GH acutely increases renal electrolyte and water reabsorption, by modulation of the kidney specific Na(+), K(+), 2Cl(-) co-transporter (NKCC2).	Water	95-100	growth hormone 1	Homo sapiens	52-54
17560155-7	2007	We recently described a possible mechanism by which GH acutely increases renal electrolyte and water reabsorption, by modulation of the kidney specific Na(+), K(+), 2Cl(-) co-transporter (NKCC2).	Water	95-100	solute carrier family 12 member 1	Homo sapiens	188-193
17560155-9	2007	We propose, that the GH-induced increase in NKCC2 activity may explain the initial water and sodium retention seen in a number of studies.	Water	83-88	growth hormone 1	Homo sapiens	21-23
17560155-9	2007	We propose, that the GH-induced increase in NKCC2 activity may explain the initial water and sodium retention seen in a number of studies.	Water	83-88	solute carrier family 12 member 1	Homo sapiens	44-49
17635944-0	2007	Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects.	Water	82-87	arginine vasopressin	Homo sapiens	18-26
17954951-1	2007	Vasopressin is a critical regulator of water homeostasis.	Water	39-44	arginine vasopressin	Homo sapiens	0-11
17896021-2	2007	A fiber-tip cantilever transduces flow rates to optical signal readout, and we demonstrate a dynamic range from 0 to 1500 microL min(-1) for operation in water.	Water	154-159	CD59 molecule (CD59 blood group)	Homo sapiens	129-135
17689848-2	2007	The links between the serotonin (5-HT) system and mood prompted us to investigate the 5-HT platelet transporter (SERT), which is considered a reliable, peripheral marker of the same structure present in presynaptic neurons, in 20 healthy volunteers before (t0) and 30 min after (t1) thermal balneotherapy with ozonized water of Montecatini spa, as compared with a similar group who underwent a bath in non-mineral water.	Water	319-324	solute carrier family 6 member 4	Homo sapiens	113-117
17689848-2	2007	The links between the serotonin (5-HT) system and mood prompted us to investigate the 5-HT platelet transporter (SERT), which is considered a reliable, peripheral marker of the same structure present in presynaptic neurons, in 20 healthy volunteers before (t0) and 30 min after (t1) thermal balneotherapy with ozonized water of Montecatini spa, as compared with a similar group who underwent a bath in non-mineral water.	Water	414-419	solute carrier family 6 member 4	Homo sapiens	113-117
17573101-0	2007	Vasopressin and angiotensin receptors of the medial septal area of the brain in the control of thirst and salt appetite induced by vasopressin in water-deprived and sodium-depleted rats.	Water	146-151	arginine vasopressin	Rattus norvegicus	0-11
17573101-0	2007	Vasopressin and angiotensin receptors of the medial septal area of the brain in the control of thirst and salt appetite induced by vasopressin in water-deprived and sodium-depleted rats.	Water	146-151	arginine vasopressin	Rattus norvegicus	131-142
17573101-2	2007	A stainless steel cannula was implanted into the medial septal area (MSA) of male Holtzman rats AVP injection enhanced water and sodium intake in a dose-dependent manner.	Water	119-124	arginine vasopressin	Rattus norvegicus	96-99
17573101-3	2007	Pretreatment with V(1) antagonist injected into the MSA produced a dose-dependent reduction, whereas prior injection of V(2) antagonist increased, in a dose-dependent manner, the water and sodium responses elicited by the administration of AVP.	Water	179-184	arginine vasopressin	Rattus norvegicus	240-243
17573101-4	2007	Both AT(1) and AT(2) antagonists administered into the MSA elicited a concentration-dependent decrease in water and sodium intake induced by AVP, while simultaneous injection of the two antagonists was more effective in decreasing AVP responses.	Water	106-111	arginine vasopressin	Rattus norvegicus	141-144
17573101-5	2007	These results also indicate that the increase in water and sodium intake induced by AVP was mediated primarily by MSA AT(1) receptors.	Water	49-54	arginine vasopressin	Rattus norvegicus	84-87
17513353-3	2007	We performed unbiased molecular dynamics simulations of the GroEL subunit protein in explicit water both with and without the nucleotide KMgATP to understand better the details of the structural transitions that enable these behaviors.	Water	94-99	GroEL	Escherichia coli	60-65
17718514-0	2007	Dynamics, hydration, and motional averaging of a loop-gated artificial protein cavity: the W191G mutant of cytochrome c peroxidase in water as revealed by molecular dynamics simulations.	Water	134-139	cytochrome c, somatic	Homo sapiens	107-119
17718514-1	2007	Five molecular dynamics simulations of the W191G cavity mutant of cytochrome c peroxidase in explicit water reveal distinct dynamic and hydration behavior depending on the closed or open state of the flexible loop gating the cavity, the binding of (K+ or small molecule) cations, and the system temperature.	Water	102-107	cytochrome c, somatic	Homo sapiens	66-78
17712447-2	2007	The pH rate profiles of values of the observed second-order rate constant log (k(Zn))(app) for Zn(X)(OH(2))-catalyzed cleavage (X = 1, 2, 3 and 4) of 2-hydroxypropyl-4-nitrophenyl phosphate (HpPNP) show downward breaks centered at the pK(a) for ionization of the respective zinc bound water.	Water	101-106	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	128-145
17574261-1	2007	In this paper, we studied the interaction between human unstimulated saliva and lysozyme-stabilized oil-in-water emulsions (10 wt/wt% oil phase, 10 mM NaCl, pH 6.7), to reveal the driving force for flocculation of these emulsions.	Water	107-112	lysozyme	Homo sapiens	80-88
17574261-2	2007	Confocal scanning laser microscopy (CSLM) showed formation of complexes between salivary proteins and lysozyme adsorbed at the oil-water interface and lysozyme in solution as well.	Water	131-136	lysozyme	Homo sapiens	102-110
17628570-4	2007	Under the optimized conditions, when 1.75 g of tea sample were extracted with boiling water, the precision ranged from 4 to 16% (RSD) and detection limits were between 4 and 145 ngL(-1), depending on the compound.	Water	86-91	leucine rich repeat containing 4C	Homo sapiens	178-184
17683784-7	2007	Results showed that AngII alone increased water but not salt intake, whereas all three doses of DOCA by themselves enhanced daily salt intake during the treatment period.	Water	42-47	angiotensinogen	Rattus norvegicus	20-25
17712447-2	2007	The pH rate profiles of values of the observed second-order rate constant log (k(Zn))(app) for Zn(X)(OH(2))-catalyzed cleavage (X = 1, 2, 3 and 4) of 2-hydroxypropyl-4-nitrophenyl phosphate (HpPNP) show downward breaks centered at the pK(a) for ionization of the respective zinc bound water.	Water	285-290	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	128-145
17700870-0	2007	The dynamics of water evaporation from partially solvated cytochrome c in the gas phase.	Water	16-21	cytochrome c, somatic	Homo sapiens	58-70
17705411-11	2007	However, water contact angles of GA-FN and SMPB-FN surfaces clearly show differences in surface hydrophilicity, therefore indicating a dependence of protein organization toward the conjugation strategy.	Water	9-14	fibronectin 1	Homo sapiens	36-38
17609209-11	2007	Anti-NERP IgGs canceled plasma vasopressin reduction in response to water loading, indicating that NERPs could be potent endogenous suppressors of vasopressin release.	Water	68-73	arginine vasopressin	Rattus norvegicus	31-42
17609209-11	2007	Anti-NERP IgGs canceled plasma vasopressin reduction in response to water loading, indicating that NERPs could be potent endogenous suppressors of vasopressin release.	Water	68-73	arginine vasopressin	Rattus norvegicus	147-158
17700870-4	2007	In this work the dynamics of water evaporation from native cytochrome c covered by a monolayer of water is studied by molecular dynamics (MD) simulations at constant energy.	Water	29-34	cytochrome c, somatic	Homo sapiens	59-71
17553938-2	2007	The antidiuretic effects of AVP are initialized by binding of AVP to the type-2 vasopressin receptor (V2R) in the kidney collecting duct (CD), resulting in the exocytic insertion of aquaporin-2 (AQP-2) water channels into the apical plasma membrane.	Water	202-207	arginine vasopressin receptor 2	Rattus norvegicus	73-105
17507666-4	2007	Since kinase activity is tightly regulated by phosphatases, we hypothesized that the dual specificity phosphatase MAP kinase phosphatase (MKP)-1 regulates p38 activity and TNF-alpha production in alveolar macrophages due to insufficient H(2)O(2) generation in response to asbestos.	Water	237-242	dual specificity phosphatase 1	Homo sapiens	114-144
17507666-4	2007	Since kinase activity is tightly regulated by phosphatases, we hypothesized that the dual specificity phosphatase MAP kinase phosphatase (MKP)-1 regulates p38 activity and TNF-alpha production in alveolar macrophages due to insufficient H(2)O(2) generation in response to asbestos.	Water	237-242	mitogen-activated protein kinase 14	Homo sapiens	155-158
17878579-1	2007	A voltammetric method for the determination of Cu(II) and Pb(II) in gasoline using sample preparation as three-component solutions (gasoline:propan-1-ol:water, 25:60:15 v/v/v) is proposed.	Water	153-158	submaxillary gland androgen regulated protein 3B	Homo sapiens	47-64
17626240-1	2007	Water reabsorption in the renal collecting duct is regulated by arginine vasopressin (AVP).	Water	0-5	arginine vasopressin	Rattus norvegicus	73-84
17596524-0	2007	The thiazide-sensitive NaCl cotransporter: a new target for acute regulation of salt and water transport by angiotensin II.	Water	89-94	angiotensinogen	Homo sapiens	108-122
17267256-6	2007	Using an antibody to the water-specific Drosophila aquaporin (DRIP), we demonstrated that DRIP-like immunoreactivity was found in both the distal and mid-Mt.	Water	25-30	aquaporin	Drosophila melanogaster	51-60
17784729-0	2007	Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging.	Water	0-5	estrogen receptor 1	Homo sapiens	46-63
17784729-5	2007	It enhances T1 and T2 nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.	Water	50-55	estrogen receptor 1	Homo sapiens	116-133
17827719-0	2007	Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells.	Water	0-5	AKT serine/threonine kinase 1	Homo sapiens	83-86
17827719-0	2007	Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells.	Water	0-5	mitogen-activated protein kinase 3	Homo sapiens	97-103
17827719-0	2007	Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells.	Water	0-5	nitric oxide synthase 3	Homo sapiens	108-112
17331768-6	2007	AQP 1 was localized in the endothelium of subepidermal capillaries and serves as a pathway for water absorption in series with the apical and basolateral membranes of the epithelium.	Water	95-100	aquaporin 1 (Colton blood group)	Homo sapiens	0-5
17720948-2	2007	Experimental hypothyroidism was induced in weanling rats by exposing their mothers to propylthiouracil (PTU) diluted in tap water (0.05% w/ v), ad libitum, during the lactational period (PTU group).	Water	124-129	nuclear RNA export factor 1	Rattus norvegicus	120-123
17886207-3	2007	Aquaretics belong to a family of vasopressin receptor antagonists, V2 in particular, that regulate tubular water reabsorption.	Water	107-112	arginine vasopressin	Homo sapiens	33-44
17990532-8	2007	In addition, nitrogen in different grain size sediments had also positive correlations with phytoplankton abundance, chlorophyll-a and NO3- concentrations of overlying water.	Water	168-173	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
17721323-5	2007	The standards diluted in water showed a reduction to 83%, 55%, and 50% after 4 cycles, to 24%, 5%, and 4% after 16 cycles for kainat-1 receptor, TNFalpha, and IFNgamma standards, respectively, when compared with a single cycle of freezing and thawing.	Water	25-30	tumor necrosis factor	Mus musculus	145-153
17721323-5	2007	The standards diluted in water showed a reduction to 83%, 55%, and 50% after 4 cycles, to 24%, 5%, and 4% after 16 cycles for kainat-1 receptor, TNFalpha, and IFNgamma standards, respectively, when compared with a single cycle of freezing and thawing.	Water	25-30	interferon gamma	Mus musculus	159-167
17350298-3	2007	iNOS specificity of inhibitor 2 is attributed to water mediated interactions and cooperative hydrogen bond networks.	Water	49-54	nitric oxide synthase 2	Homo sapiens	0-4
17900089-3	2007	We undertook a study to determine if the lactoperoxidase system (LPOS) will inhibit the growth of E. sakazakii in a milk-based powdered infant formula reconstituted with water.	Water	170-175	lactoperoxidase	Homo sapiens	41-56
17590357-8	2007	Water-soluble non-ionic solubilizers/surfactants are potent inhibitors of hERG K(+) current with IC(20) concentrations of 0.07% (Cremophor EL) or lower (Tween 20, Tween 80: approximately 0.001%).	Water	0-5	ETS transcription factor ERG	Homo sapiens	74-78
17584847-11	2007	Na(+) and water content of stools was diminished in IK1-null animals.	Water	10-15	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	52-55
17697714-1	2007	This study concerns effects on water-borne lead from combinations of chlorine (CL) or chloramines (CA) with fluosilicic acid (FSA) or sodium fluoride (NaF).	Water	31-36	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
17590357-6	2007	Water-soluble organic (co)solvents inhibited hERG K(+) currents (IC(20), %/mM): 0.7/152, ethanol; 0.9/67, Transcutol; 1.2/154, DMSO (dimethylsulfoxide); 1.6/389, acetonitrile; 1.9/48, polyethylene glycol 400; 2.1/660, methanol.	Water	0-5	ETS transcription factor ERG	Homo sapiens	45-49
17884796-7	2007	Serum MPO activity was closely correlated with AOPP (r=0.335, P&lt;0.05) and CRP (r=0.369 or 0.347, P&lt;0.05) before or after use of ultrapure water.	Water	144-149	myeloperoxidase	Homo sapiens	6-9
17724188-1	2007	PURPOSE: Recent studies have shown that rabbit corneal keratocytes abundantly express two water-soluble proteins, transketolase (TKT) and aldehyde dehydrogenase class 1A1 (ALDH1A1), in vivo and that these proteins may contribute to corneal transparency at the cellular level.	Water	90-95	transketolase	Oryctolagus cuniculus	114-127
17724188-1	2007	PURPOSE: Recent studies have shown that rabbit corneal keratocytes abundantly express two water-soluble proteins, transketolase (TKT) and aldehyde dehydrogenase class 1A1 (ALDH1A1), in vivo and that these proteins may contribute to corneal transparency at the cellular level.	Water	90-95	transketolase	Oryctolagus cuniculus	129-132
17884796-6	2007	Use of ultrapure water for 6 months significantly improved serum AOPP, MDA, GSH-Px, MPO, Alb, CRP, neopterin, and TNF-alpha levels (P&lt;0.05), and the level of IL-6 was further reduced after 12 months (P&lt;0.05).	Water	17-22	myeloperoxidase	Homo sapiens	84-87
17884796-6	2007	Use of ultrapure water for 6 months significantly improved serum AOPP, MDA, GSH-Px, MPO, Alb, CRP, neopterin, and TNF-alpha levels (P&lt;0.05), and the level of IL-6 was further reduced after 12 months (P&lt;0.05).	Water	17-22	albumin	Homo sapiens	89-92
17884796-6	2007	Use of ultrapure water for 6 months significantly improved serum AOPP, MDA, GSH-Px, MPO, Alb, CRP, neopterin, and TNF-alpha levels (P&lt;0.05), and the level of IL-6 was further reduced after 12 months (P&lt;0.05).	Water	17-22	C-reactive protein	Homo sapiens	94-97
17884796-6	2007	Use of ultrapure water for 6 months significantly improved serum AOPP, MDA, GSH-Px, MPO, Alb, CRP, neopterin, and TNF-alpha levels (P&lt;0.05), and the level of IL-6 was further reduced after 12 months (P&lt;0.05).	Water	17-22	tumor necrosis factor	Homo sapiens	114-123
17884796-6	2007	Use of ultrapure water for 6 months significantly improved serum AOPP, MDA, GSH-Px, MPO, Alb, CRP, neopterin, and TNF-alpha levels (P&lt;0.05), and the level of IL-6 was further reduced after 12 months (P&lt;0.05).	Water	17-22	interleukin 6	Homo sapiens	161-165
17970536-0	2007	Does bicarbonated mineral water rich in sodium change insulin sensitivity of postmenopausal women?	Water	26-31	insulin	Homo sapiens	54-61
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Water	161-166	S100 calcium binding protein A10	Homo sapiens	119-123
17970536-9	2007	Insulin concentrations showed a significant time effect (p &lt; 0.0001) and a significant water x time interaction (p &lt; 0.021).	Water	90-95	insulin	Homo sapiens	0-7
17924462-10	2007	CONCLUSION: AQP9 may play an important role in the follicle development and antrum formation through water transport and AQP9 may be involved in the mechanism of follicle development in PCOS.	Water	101-106	aquaporin 9	Homo sapiens	12-16
17584741-3	2007	In this study, it is shown that one of these, AtNIP2;1, is exquisitely sensitive to water logging and anoxia stress.	Water	84-89	NOD26-like intrinsic protein 2;1	Arabidopsis thaliana	46-54
17584741-8	2007	Functional analysis of AtNIP2;1 expressed in Xenopus oocytes shows that the protein differs from soybean nodulin 26, showing minimal water and glycerol transport.	Water	133-138	NOD26-like intrinsic protein 2;1	Arabidopsis thaliana	23-31
17573040-3	2007	Herein is the first report of PPARgamma activation by troglitazone (TG) exerting its inhibitory effects on LDL-induced cell proliferation via generation not of H(2)O(2), but of O2(.-), and the subsequent activation of Erk1/2 in hAoSMCs.	Water	160-165	peroxisome proliferator activated receptor gamma	Homo sapiens	30-39
17561435-9	2007	A statistically higher MN frequency was found in bone marrow of animals exposed to As compared with controls that received tap water (0.92+/-0.29% versus 0.38+/-0.13%, respectively).	Water	127-132	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	123-126
17608521-2	2007	Over a wide range of conditions, both for solvation in the Lennard-Jones liquid and in the SPC model of water, it is shown that the mean solvent density varies linearly with changes in solvent-solute adhesion or attractive energy strength.	Water	104-109	proline rich protein gene cluster	Homo sapiens	91-94
17625839-5	2007	MS-325 binds to human serum albumin (HSA) in plasma resulting in an extended plasma half-life, retention of the agent within the blood compartment, and an increased relaxation rate of water protons in plasma.	Water	184-189	albumin	Homo sapiens	22-35
17553940-1	2007	Collecting duct-derived endothelin-1 (ET-1) reduces blood pressure and inhibits Na and water reabsorption.	Water	87-92	endothelin 1	Rattus norvegicus	24-36
17553940-1	2007	Collecting duct-derived endothelin-1 (ET-1) reduces blood pressure and inhibits Na and water reabsorption.	Water	87-92	endothelin 1	Rattus norvegicus	38-42
17558559-5	2007	Hydroxylation of the formylglycine residue by a water molecule forming the activated hydroxylformylglycine (a formylglycine hydrate or a gem-diol) is a necessary step for the enzyme"s sulfatase activity.	Water	48-53	arylsulfatase family member H	Homo sapiens	184-193
17628030-5	2007	After cleavage of the protective groups and purification on reverse phase HPLC, a highly water-soluble methotrexate-peptide derivative was obtained that binds rapidly and selectively to human serum albumin.	Water	89-94	albumin	Homo sapiens	198-205
17429015-0	2007	The role of aquaporin 3 in the movement of water and cryoprotectants in mouse morulae.	Water	43-48	aquaporin 3	Mus musculus	12-23
17429015-2	2007	Previously, we have shown in mouse morulae that water and glycerol move across the plasma membrane by facilitated diffusion, and we have suggested that aquaporin 3 plays an important role in their movement.	Water	48-53	aquaporin 3	Mus musculus	152-163
17429015-3	2007	In the present study, we clarify the contribution of aquaporin 3 to the movement of water and various cryoprotectants in mouse morulae by measuring the Arrhenius activation energies for permeability to cryoprotectants and water, through artificial expression of aquaporin 3 using Aqp3 cRNA in mouse oocytes, and by suppressing the expression of aquaporin 3 in morulae by injecting double-stranded RNA of Aqp3 at the one-cell zygote stage.	Water	84-89	aquaporin 3	Mus musculus	53-64
17429015-4	2007	The results show that aquaporin 3 plays an important role in the facilitated diffusion of water, glycerol, and ethylene glycol, but not of acetamide and dimethylsulfoxide.	Water	90-95	aquaporin 3	Mus musculus	22-33
17429015-5	2007	On the other hand, in a propylene glycol solution, aquaporin 3 in morulae transported neither propylene glycol nor water by facilitated diffusion, probably because of strong water-solute interactions.	Water	115-120	aquaporin 3	Mus musculus	51-62
17429015-5	2007	On the other hand, in a propylene glycol solution, aquaporin 3 in morulae transported neither propylene glycol nor water by facilitated diffusion, probably because of strong water-solute interactions.	Water	174-179	aquaporin 3	Mus musculus	51-62
17431427-6	2007	MIA expression in vivo suppresses p66shc-stimulated increase in endogenous hydrogen peroxide (H(2)O(2)), and inhibits basal and H(2)O(2)-induced phosphorylation of p66shc on serine 36 and H(2)O(2)-induced death.	Water	94-99	MIA SH3 domain containing	Homo sapiens	0-3
32689392-7	2007	ABA does not significantly affect Arabidopsis mesophyll protoplast volume regulation, whereas AtPNP-A and synthetic peptides promote water uptake into the protoplasts causing swelling.	Water	133-138	plant natriuretic peptide A	Arabidopsis thaliana	94-101
17671199-2	2007	We here report that addition of ZnSO(4) to the drinking water of mice induces expression of heat shock protein 70 (HSP70) in several organs, notably the gastrointestinal track.	Water	56-61	heat shock protein 1B	Mus musculus	92-113
17671199-2	2007	We here report that addition of ZnSO(4) to the drinking water of mice induces expression of heat shock protein 70 (HSP70) in several organs, notably the gastrointestinal track.	Water	56-61	heat shock protein 1B	Mus musculus	115-120
18018383-2	2007	It is usually caused by dysregulation of arginine vasopressin (AVP) homeostasis which accompanies disorders associated with water retention such as congestive heart failure and cirrhosis, or follows euvolemic states such as syndrome of inapprioprate secretion of antidiuretic hormone.	Water	124-129	arginine vasopressin	Homo sapiens	50-61
17625862-0	2007	Gas-phase reactions of ClMn(H2O)+ with polar and nonpolar hydrocarbons in a mass spectrometer.	Water	28-31	calmin	Homo sapiens	23-27
17725857-6	2007	Furthermore, the water-soluble low-molecular-weight beta-glucan (100 mg kg(-1)) prevented the reduction of IL-6 and IL-12 production by splenocytes caused by restraint stress.	Water	17-22	interleukin 6	Mus musculus	107-111
17725857-7	2007	These findings suggest that the inhibitory actions of water-soluble low-molecular-weight beta-glucan on the increase in corticosterone level and reduction of NK activity induced by restraint stress may be associated with the abrogation of the IL-6 and IL-12 reduction caused by the stress.	Water	54-59	interleukin 6	Mus musculus	243-247
17619177-0	2007	Inhibition of inducible nitric oxide synthase in vitro and in vivo by a water-soluble extract of Wendita calysina leaves.	Water	72-77	nitric oxide synthase 2	Rattus norvegicus	14-45
17549682-9	2007	Reintroducing either AQP1 or AQP4 stably into glioma cell lines allowed us to show that each AQP is sufficient to restore water permeability.	Water	122-127	aquaporin 1 (Colton blood group)	Homo sapiens	21-25
17620103-4	2007	This is opposite to classical Na(+) transporting tissues, such as the kidney, where Na(+) and water reabsorption is mediated by 11beta-hydroxysteroid dehydrogenase type 2 that protects the mineralocorticoid receptor by abrogating active cortisol to inactive cortisone.	Water	94-99	11-beta-hydroxysteroid dehydrogenase type 2	Oryctolagus cuniculus	128-170
17631057-0	2007	Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells.	Water	33-38	angiotensinogen	Homo sapiens	64-78
17631057-3	2007	In the present study, we found that the water extract of ZoaGumHwan (ZGH), a Korean herbal remedy, dose-dependently inhibited Ang II-induced U937 monocyte adhesion to human umbilical vein endothelial cells (HUVECs) and mRNA expression of MCP-1 in HUVECs and C-C chemokine receptor 2 (CCR-2) in U937 cells.	Water	40-45	C-C motif chemokine receptor 2	Homo sapiens	258-282
17631057-3	2007	In the present study, we found that the water extract of ZoaGumHwan (ZGH), a Korean herbal remedy, dose-dependently inhibited Ang II-induced U937 monocyte adhesion to human umbilical vein endothelial cells (HUVECs) and mRNA expression of MCP-1 in HUVECs and C-C chemokine receptor 2 (CCR-2) in U937 cells.	Water	40-45	C-C motif chemokine receptor 2	Homo sapiens	284-289
17616217-1	2007	The structure of the water-solid interface for widely varying surface properties is investigated with Monte Carlo simulations using the SPC/E water model.	Water	21-26	proline rich protein gene cluster	Homo sapiens	136-139
17477978-0	2007	Water maze impairments after combined depletion of somatostatin and serotonin in the rat.	Water	0-5	somatostatin	Rattus norvegicus	51-63
17672727-0	2007	Role of the solvent in the dynamical transitions of proteins: the case of the lysozyme-water system.	Water	87-92	lysozyme	Homo sapiens	78-86
17672727-1	2007	We study the dynamics of hydration water in the protein lysozyme in the temperature range 180 K&lt;T&lt;360 K using Fourier-transform-infrared and nuclear magnetic resonance (NMR) spectroscopies.	Water	35-40	lysozyme	Homo sapiens	56-64
17222507-0	2007	Determination of Co(II) in water and soil samples using spectrophotometry coupled with preconcentration on 4-amino methyl pyridine anchored silica gel column.	Water	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
17222507-7	2007	The present method was successfully applied for the determination of Co(II) in various water and soil samples.	Water	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
17449664-6	2007	The p(f) matrices from molecular dynamics simulations of five aquaporins (AQP0, AQP1, AQP4, AqpZ, and GlpF) indicated that the reduction in the water correlation across the Asn-Pro-Ala region, and the small local permeability around the ar/R region, characterize the transport efficiency of water.	Water	144-149	major intrinsic protein of lens fiber	Homo sapiens	74-78
17656579-1	2007	The monomeric Alzheimer"s beta amyloid peptide, Abeta, is known to adopt a disordered state in water at room temperature, and a circular dichroism (CD) spectroscopy experiment has provided the secondary-structure contents for the disordered state: 70% random, 25% beta-structural, and 5% helical.	Water	95-100	amyloid beta precursor protein	Homo sapiens	26-46
17656579-1	2007	The monomeric Alzheimer"s beta amyloid peptide, Abeta, is known to adopt a disordered state in water at room temperature, and a circular dichroism (CD) spectroscopy experiment has provided the secondary-structure contents for the disordered state: 70% random, 25% beta-structural, and 5% helical.	Water	95-100	amyloid beta precursor protein	Homo sapiens	48-53
17656579-2	2007	We performed an enhanced conformational sampling (multicanonical molecular dynamics simulation) of a 25-residue segment (residues 12-36) of Abeta in explicit water and obtained the conformational ensemble over a wide temperature range.	Water	158-163	amyloid beta precursor protein	Homo sapiens	140-145
17656579-6	2007	The helical cluster had a similarity with a stable helical structure for monomeric Abeta in 2,2,2-trifluoroethanol (TFE)/water determined by an NMR experiment: The positions of helices in the helical cluster were the same as those in the NMR structure, and the residue-residue contact patterns were also similar with those of the NMR structure.	Water	121-126	amyloid beta precursor protein	Homo sapiens	83-88
17449664-6	2007	The p(f) matrices from molecular dynamics simulations of five aquaporins (AQP0, AQP1, AQP4, AqpZ, and GlpF) indicated that the reduction in the water correlation across the Asn-Pro-Ala region, and the small local permeability around the ar/R region, characterize the transport efficiency of water.	Water	144-149	aquaporin 1 (Colton blood group)	Homo sapiens	80-84
17449664-6	2007	The p(f) matrices from molecular dynamics simulations of five aquaporins (AQP0, AQP1, AQP4, AqpZ, and GlpF) indicated that the reduction in the water correlation across the Asn-Pro-Ala region, and the small local permeability around the ar/R region, characterize the transport efficiency of water.	Water	291-296	major intrinsic protein of lens fiber	Homo sapiens	74-78
17449664-7	2007	These structural determinants in water permeation were confirmed in molecular dynamics simulations of three mutants of AqpZ, which mimic AQP1.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	137-141
17519227-5	2007	Using H (18)(2)O water, the compounds were shown to form by direct oxidation of endogenous phosphatidylethanolamine (PE) by 15-LOX, with PE being the preferred phospholipid pool containing 15-HETE.	Water	17-22	arachidonate 15-lipoxygenase	Homo sapiens	127-130
17603937-7	2007	Interestingly, following treatment with H(2)O(2), nuclear thioredoxin-1 (Trx1) redox status was protected by NLS-Prx1, and cytoplasmic Trx1 was protected by NES-Prx1.	Water	40-45	nestin	Homo sapiens	157-160
17553491-8	2007	These results show that IL-13 interferes with ion and water channel expression and localization during epithelial regeneration and may thereby influence mucus composition and hydration.	Water	54-59	interleukin 13	Homo sapiens	24-29
17625559-5	2007	We find that absorption by water vapour is the most likely cause of the wavelength-dependent variations in the effective radius of the planet at the infrared wavelengths 3.6 mum, 5.8 mum (both ref.	Water	27-32	latexin	Homo sapiens	183-186
17532339-5	2007	Consistent with the previous studies, two well-fixed magnesium ions are coordinated by five active site residues and five water molecules in the PDP1c catalytic center.	Water	122-127	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	145-149
17150302-3	2007	An increase in the cellular levels of H(2)O(2) has been linked to several key alterations in cancer, including DNA alterations, cell proliferation, apoptosis resistance, metastasis, angiogenesis and hypoxia-inducible factor 1 (HIF-1) activation.	Water	38-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	199-225
17150302-3	2007	An increase in the cellular levels of H(2)O(2) has been linked to several key alterations in cancer, including DNA alterations, cell proliferation, apoptosis resistance, metastasis, angiogenesis and hypoxia-inducible factor 1 (HIF-1) activation.	Water	38-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	227-232
17625559-5	2007	We find that absorption by water vapour is the most likely cause of the wavelength-dependent variations in the effective radius of the planet at the infrared wavelengths 3.6 mum, 5.8 mum (both ref.	Water	27-32	latexin	Homo sapiens	174-177
17575980-4	2007	Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively.	Water	121-126	solute carrier family 6 member 4	Homo sapiens	58-64
17559208-7	2007	Specifically, new coordination modes of galactitol and complicated topology networks were found in 2Ca(NO3)2.C6H14O6.H2O and Sr(NO3)2.C6H14O6.	Water	117-120	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
17336361-3	2007	SOD1 converts superoxide to peroxide; GPx1 converts peroxide to water.	Water	64-69	superoxide dismutase 1	Homo sapiens	0-4
17627346-1	2007	A low barrier in the reaction pathway between the double Rydberg isomer of OH(3) (-) and a hydride-water complex indicates that the former species is more difficult to isolate and characterize through anion photoelectron spectroscopy than the well known double Rydberg anion (DRA), tetrahedral NH(4) (-).	Water	99-104	solute carrier family 26 member 3	Homo sapiens	276-279
17526062-0	2007	CYP3A4 activity in the presence of organic cosolvents, ionic liquids, or water-immiscible organic solvents.	Water	73-78	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
17526062-4	2007	We show that CYP3A4 tolerates only small amounts (&lt;15 %) of water-miscible organic cosolvents or ionic liquids before its activity toward testosterone drops below detection.	Water	63-68	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	13-19
17526062-6	2007	CYP3A4 activity in the absence of buffer was only &gt;or=10 % in solvents of the alkane series, with a minimum of 0.85 % water, and with the addition of sucrose and testosterone before enzyme lyophilization.	Water	121-126	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
16933200-1	2007	The melastatin-related transient receptor potential channel TRPM2 is a plasma membrane Ca(2+)-permeable cation channel that is activated by hydrogen peroxide (H(2)O(2)) as a consequence of oxidative stress although the channel activation by H(2)O(2) appears to represent a cell-specific process in cells with endogenous expression of TRPM2.	Water	159-164	transient receptor potential cation channel subfamily M member 2	Cricetulus griseus	60-65
17552523-5	2007	The very low water density in the middle of the nAChR pore indicated the existence of a hydrophobic constriction.	Water	13-18	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	48-53
17466972-10	2007	In conclusion we found that in lithium-induced kidney urine concentrating deficit in man, the cyclic AMP generation in response to 1-desamino-8-D-arginine-vasopressin administration after water loading, is impaired.	Water	188-193	arginine vasopressin	Homo sapiens	155-166
17555301-8	2007	These findings suggest that the mechanisms of interactions of CYP3A4 with 1-PB and testosterone involve an effector-induced transition that displaces a system of conformational equilibria in the enzyme toward the state(s) with decreased solvent accessibility of the active site so that the flux of water into the heme pocket is impeded and the high-spin state of the heme iron is stabilized.	Water	298-303	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-68
17475897-11	2007	These results suggest that altered expression of alpha-, beta-, and gamma-ENaC may contribute to impaired renal sodium and water handling in response to ureteral obstruction.	Water	123-128	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	68-78
17663307-1	2007	Hyponatraemia often complicates the treatment of underlying conditions in patients who are seriously ill. Arginine vasopressin receptor antagonists block the action of arginine vasopressin and correct sodium and water imbalance in patients with euvolaemic or hypervolaemic hyponatraemia.	Water	212-217	arginine vasopressin	Homo sapiens	115-126
16933200-1	2007	The melastatin-related transient receptor potential channel TRPM2 is a plasma membrane Ca(2+)-permeable cation channel that is activated by hydrogen peroxide (H(2)O(2)) as a consequence of oxidative stress although the channel activation by H(2)O(2) appears to represent a cell-specific process in cells with endogenous expression of TRPM2.	Water	159-164	transient receptor potential cation channel subfamily M member 2	Cricetulus griseus	334-339
16933200-1	2007	The melastatin-related transient receptor potential channel TRPM2 is a plasma membrane Ca(2+)-permeable cation channel that is activated by hydrogen peroxide (H(2)O(2)) as a consequence of oxidative stress although the channel activation by H(2)O(2) appears to represent a cell-specific process in cells with endogenous expression of TRPM2.	Water	241-246	transient receptor potential cation channel subfamily M member 2	Cricetulus griseus	60-65
16933200-1	2007	The melastatin-related transient receptor potential channel TRPM2 is a plasma membrane Ca(2+)-permeable cation channel that is activated by hydrogen peroxide (H(2)O(2)) as a consequence of oxidative stress although the channel activation by H(2)O(2) appears to represent a cell-specific process in cells with endogenous expression of TRPM2.	Water	241-246	transient receptor potential cation channel subfamily M member 2	Cricetulus griseus	334-339
16933200-4	2007	Due to lack of known antogonists of this channel, we demonstrate in CHO cells that FA inhibits TRPM2 activated by extracellular H(2)O(2).	Water	128-133	transient receptor potential cation channel subfamily M member 2	Cricetulus griseus	95-100
17556883-1	2007	PURPOSE OF REVIEW: Angiotensin II regulates vasoconstriction, homeostasis of salt and water, and cardiovascular hypertrophy and remodeling.	Water	86-91	angiotensinogen	Homo sapiens	19-33
17667213-1	2007	The safety and effect of an acetone-water neem leaf extract (IRAB) on CD4 cells was investigated in 60 HIV/AIDS patients as part of an ongoing study to determine the influence of neem on immunity and viral load in HIV/AIDS.	Water	36-41	CD4 molecule	Homo sapiens	70-73
17171285-9	2007	It was indicated that cation exchange and Cl-salt inputs are the major process controlling the water chemistry of the low Cl(-) and high [NO3-] (group 2) and high Cl(-) and [NO3-] (group 4).	Water	95-100	NBL1, DAN family BMP antagonist	Homo sapiens	138-141
17171285-9	2007	It was indicated that cation exchange and Cl-salt inputs are the major process controlling the water chemistry of the low Cl(-) and high [NO3-] (group 2) and high Cl(-) and [NO3-] (group 4).	Water	95-100	NBL1, DAN family BMP antagonist	Homo sapiens	174-177
17392396-7	2007	as a solution, 1) in water and 2) in GFJ, showed, respectively, a 49% increase (CYP3A-inhibited) and a 116% increase (both CYP3A and gut esterase-inhibited) in the portal plasma exposure to the active acid, compared with a non-GFJ pretreatment group.	Water	21-26	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	80-85
17412804-4	2007	During release, VP travels through the blood stream to specific receptor targets located in the kidney in which it increases the permeability of the collecting ducts to water, reducing the renal excretion of water, thus promoting water conservation.	Water	169-174	arginine vasopressin	Rattus norvegicus	16-18
17537436-5	2007	Plasma osmolality, vasopressin (AVP), adrenocorticotropic hormone (ACTH) and corticosterone were elevated by water restriction and reduced after drinking in both models.	Water	109-114	arginine vasopressin	Rattus norvegicus	19-30
17412804-4	2007	During release, VP travels through the blood stream to specific receptor targets located in the kidney in which it increases the permeability of the collecting ducts to water, reducing the renal excretion of water, thus promoting water conservation.	Water	208-213	arginine vasopressin	Rattus norvegicus	16-18
17695904-1	2007	The use of zero valent iron (Fe0) for the remediation of water contaminated with carbon disulfide (CS2), a common groundwater contaminant, has been evaluated in this study.	Water	57-62	chorionic somatomammotropin hormone 2	Homo sapiens	99-102
17537436-6	2007	Fos expression was elevated in AVP-positive magnocellular PVN neurons and AVP- and corticotropin releasing hormone (CRH)-positive parvocellular PVN neurons after water restriction.	Water	162-167	corticotropin releasing hormone	Rattus norvegicus	74-114
17537436-6	2007	Fos expression was elevated in AVP-positive magnocellular PVN neurons and AVP- and corticotropin releasing hormone (CRH)-positive parvocellular PVN neurons after water restriction.	Water	162-167	corticotropin releasing hormone	Rattus norvegicus	116-119
17712057-3	2007	Arginine vasopressin-receptor antagonists, a novel class of agents that block the action of arginine vasopressin on V2 receptors in the renal collecting ducts, may provide specific correction of sodium and water imbalance in hyponatremia by promoting free water clearance while sparing electrolytes (aquaresis).	Water	206-211	arginine vasopressin	Homo sapiens	9-20
17591989-10	2007	The slightly lower observed osmotic permeability of D(2)O compared to H(2)O in AQP1 is most likely due to the lower self diffusion constant of D(2)O.	Water	70-75	aquaporin 1	Bos taurus	79-83
17452475-0	2007	Vacuolating cytotoxin in Helicobacter pylori water-soluble proteins upregulates chemokine expression in human eosinophils via Ca2+ influx, mitochondrial reactive oxygen intermediates, and NF-kappaB activation.	Water	45-50	nuclear factor kappa B subunit 1	Homo sapiens	188-197
17591989-0	2007	Water and deuterium oxide permeability through aquaporin 1: MD predictions and experimental verification.	Water	0-5	aquaporin 1	Bos taurus	47-58
17712057-3	2007	Arginine vasopressin-receptor antagonists, a novel class of agents that block the action of arginine vasopressin on V2 receptors in the renal collecting ducts, may provide specific correction of sodium and water imbalance in hyponatremia by promoting free water clearance while sparing electrolytes (aquaresis).	Water	206-211	arginine vasopressin	Homo sapiens	101-112
17712057-3	2007	Arginine vasopressin-receptor antagonists, a novel class of agents that block the action of arginine vasopressin on V2 receptors in the renal collecting ducts, may provide specific correction of sodium and water imbalance in hyponatremia by promoting free water clearance while sparing electrolytes (aquaresis).	Water	256-261	arginine vasopressin	Homo sapiens	9-20
17712057-3	2007	Arginine vasopressin-receptor antagonists, a novel class of agents that block the action of arginine vasopressin on V2 receptors in the renal collecting ducts, may provide specific correction of sodium and water imbalance in hyponatremia by promoting free water clearance while sparing electrolytes (aquaresis).	Water	256-261	arginine vasopressin	Homo sapiens	101-112
17536854-2	2007	The Soret peak in the spectrum of the iNOS heme domain (iNOSoxy) shifts from 423 to 390 nm upon addition of a sensitizer-wire, [ReI-imidazole-(CH2)8-nitroarginine]+, or [ReC8argNO2]+, owing to partial displacement of the water ligand in the active site.	Water	221-226	nitric oxide synthase 2	Homo sapiens	38-42
17623437-7	2007	Spiked tap water was used for the preconcentration and determination of Pb(II) by flame atomic absorption spectrometry, and a 100% recovery was obtained.	Water	11-16	submaxillary gland androgen regulated protein 3B	Homo sapiens	72-78
17717924-4	2007	RESULTS: In the groups of mouse stressed by water platform environment, the level of serum glucocorticoid, the TFAR-19 protein expression and the Annexin-V apoptosis protein proportion increased in the thymus cell along with the stress time prolonging (P&lt;0.05 or P &lt;0.01).	Water	44-49	programmed cell death 5	Mus musculus	111-118
17547420-7	2007	Recoveries from the analyte-fortified tap water and ultrapure water were in the range of 80-114% .	Water	42-47	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	38-41
17592470-3	2007	The main factor contributing to the development of hospital-acquired hyponatremia is routine use of hypotonic fluids in patients in whom the excretion of free water, which is retained in response to excess arginine vasopressin (AVP), might be impaired.	Water	159-164	arginine vasopressin	Homo sapiens	215-226
17169404-3	2007	Inorganic arsenate, As(V), appears to be the dominant species in the spring water samples tested.	Water	76-81	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	20-25
17614580-0	2007	Helium atom scattering study of the interaction of water with the BaF2(111) surface.	Water	51-56	BANF family member 2	Homo sapiens	66-70
17614580-1	2007	The interaction of water with the BaF2(111) single crystal surface is investigated using the helium atom scattering technique.	Water	19-24	BANF family member 2	Homo sapiens	34-38
17525633-2	2007	Whereas most data were collected on aquaporin-4 (AQP4) in astrocytes, only little attention was paid to AQP9 which is a water channel transporting glycerol, mannitol, and urea as well.	Water	120-125	aquaporin 9	Homo sapiens	104-108
17579720-7	2007	The hAFP-ice interaction is further strengthened by the bound Ca(2+) through the coordination with a water molecule of the ice lattice.	Water	101-106	alpha fetoprotein	Homo sapiens	4-8
17436292-11	2007	However, when water is returned, contributions to the network controlling responses evidently come from hypocretin/orexin, but not CRH or MCH, neurons in the LHA.	Water	14-19	hypocretin neuropeptide precursor	Rattus norvegicus	104-121
17520116-1	2007	Single nanogram amounts of the explosives TNT, RDX, HMX, PETN and their mixtures were detected and identified in a few seconds on the surface of human skin without any sample preparation by desorption electrospray ionization (DESI) using a spray solution of methanol-water doped with sodium chloride to form the chloride adducts with RDX, HMX, and PETN while TNT was examined as the radical anion and tandem mass spectrometry was used to confirm the identifications.	Water	267-272	chromosome 16 open reading frame 82	Homo sapiens	42-45
17500523-3	2007	A water soluble RAFT agent was conjugated to a model protein, bovine serum albumin (BSA), via its free thiol group at Cys-34 residue.	Water	2-7	albumin	Homo sapiens	69-82
17600444-0	2007	Preferential hydration of lysozyme in water/glycerol mixtures: a small-angle neutron scattering study.	Water	38-43	lysozyme	Homo sapiens	26-34
17600444-1	2007	In solution small-angle neutron scattering has been used to study the solvation properties of lysozyme dissolved in water/glycerol mixtures.	Water	116-121	lysozyme	Homo sapiens	94-102
17581036-1	2007	Initial simulated values of the surface tension for the SPC/E water model have indicated excellent agreement with experiment.	Water	62-67	proline rich protein gene cluster	Homo sapiens	56-59
17283068-2	2007	A novel assay using water-soluble analogs of dihydroceramide, dihydroceramidoids (D-erythro-dhCCPS analogs), was used to measure desaturase activity in situ.	Water	20-25	Desaturase 1	Drosophila melanogaster	129-139
17553997-5	2007	In the present study, we found that water maze training significantly decreased CK2 activity in the rat hippocampal CA1 area but not in the dentate gyrus (DG) area.	Water	36-41	casein kinase 2 beta	Rattus norvegicus	80-83
16945374-4	2007	ApoA-IV also inhibited the oxidation of LDL by the water-soluble free-radical generator 2,2"-azobis(amidinopropane) dihydrochloride (AAPH; 1 mM), as shown by the two-fold increase in the time for half maximal conjugated diene formation (T(1/2); P&lt;0.05) suggesting it can also scavenge free radicals in the aqueous phase.	Water	51-56	apolipoprotein A4	Homo sapiens	0-7
17451824-4	2007	When treated with H(2)O(2), Caco-2 cell monolayers grown on permeable supports exhibited several remarkable features of barrier dysfunction as follows: a decrease in transepithelial electrical resistance, an increase in paracellular permeability to dextran, and a disruption of the intercellular junctional localization of the scaffolding protein ZO-1.	Water	18-23	tight junction protein 1	Homo sapiens	347-351
17397796-6	2007	In contrast, both the librational motion and the accessibility of the chains to water are very different in the hydrophobic fatty acid binding sites of HSA from those in membranes.	Water	80-85	albumin	Homo sapiens	152-155
17339884-6	2007	The expression of caspase-3 and caspase-9 induced by H(2)O(2) in HLE cells was significantly reduced by parthenolide both at the protein and mRNA levels, and the activation of caspase-3 and caspase-9 was also suppressed by parthenolide in a dose-dependent manner.	Water	53-58	caspase 3	Homo sapiens	18-27
17339884-6	2007	The expression of caspase-3 and caspase-9 induced by H(2)O(2) in HLE cells was significantly reduced by parthenolide both at the protein and mRNA levels, and the activation of caspase-3 and caspase-9 was also suppressed by parthenolide in a dose-dependent manner.	Water	53-58	caspase 3	Homo sapiens	176-185
17320442-10	2007	As AQP-1 functions to allow water movement across mammalian cell membranes, its presence in water-permeable cells in a bird suggests it may have a similar function.	Water	28-33	aquaporin 1 (Colton blood group)	Homo sapiens	3-8
17320442-10	2007	As AQP-1 functions to allow water movement across mammalian cell membranes, its presence in water-permeable cells in a bird suggests it may have a similar function.	Water	92-97	aquaporin 1 (Colton blood group)	Homo sapiens	3-8
17508773-3	2007	We have focused in this work on the usage of computer-aided molecular design by virtual screening, molecular dynamics with implicit and explicit water solvation, density functional, molecular interaction field studies, docking procedures, ADMET predictions in order to propose novel potential AChE inhibitor for the treatment of Alzheimer"s disease.	Water	145-150	acetylcholinesterase (Cartwright blood group)	Homo sapiens	293-297
17384340-6	2007	There was significantly lower ROS generation and NF-kappaB binding following orange juice, fructose, and water compared with glucose (P &lt; 0.001 for all).	Water	105-110	nuclear factor kappa B subunit 1	Homo sapiens	49-58
24459495-5	2007	In conclusion, angiotensin II, and aldosterone could play a role in the regulation of renal water reabsorption by changing intracellular AQP2 targeting and/or AQP2 abundance, in addition to the vasopressin.	Water	92-97	angiotensinogen	Rattus norvegicus	15-29
17405146-7	2007	We also demonstrate that p34 (a component of the Arp2/3 complex), WASP/WAVE proteins, actin, alpha-tubulin, Rac, Cdc42, vinculin, and focal adhesion kinase are detected in water-shocked myelin purified from brain.	Water	172-177	AKT serine/threonine kinase 1	Homo sapiens	108-111
17593005-11	2007	The GSNO treatment of EAU animals significantly attenuated the levels of TNF-alpha, IL-1beta, IFN-gamma, and IL-10 in retinas, as measured by quantitative real-time polymerase chain reaction analysis.	Water	22-25	tumor necrosis factor	Mus musculus	73-82
17572013-2	2007	Mutations in the CFTR gene result in defective sodium, chloride, and water transport in the epithelial cells of the respiratory, hepatobiliary, gastrointestinal, and reproductive tracts, the pancreas, and the eye.	Water	69-74	CF transmembrane conductance regulator	Homo sapiens	17-21
17624105-2	2007	The transport and removal ratios for COD(Cr), NH4- -N, and NO3- -N in river water infiltrated through the riverbed colmation layer, the unsaturated zone, and the saturated aquifer, as well as to the pumping well, were investigated.	Water	76-81	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
17593005-11	2007	The GSNO treatment of EAU animals significantly attenuated the levels of TNF-alpha, IL-1beta, IFN-gamma, and IL-10 in retinas, as measured by quantitative real-time polymerase chain reaction analysis.	Water	22-25	interleukin 1 beta	Mus musculus	84-92
17593005-11	2007	The GSNO treatment of EAU animals significantly attenuated the levels of TNF-alpha, IL-1beta, IFN-gamma, and IL-10 in retinas, as measured by quantitative real-time polymerase chain reaction analysis.	Water	22-25	interferon gamma	Mus musculus	94-103
16769153-9	2007	Under water-stressed conditions, uniconazole increased the content of proline and soluble sugars, and the activities of superoxide dismutase and peroxidase in soybean leaves but not the malondialdehyde content or electrical conductivity.	Water	6-11	peroxidase	Glycine max	145-155
17593005-11	2007	The GSNO treatment of EAU animals significantly attenuated the levels of TNF-alpha, IL-1beta, IFN-gamma, and IL-10 in retinas, as measured by quantitative real-time polymerase chain reaction analysis.	Water	22-25	interleukin 10	Mus musculus	109-114
17485712-1	2007	Nitrate (NO3-) leaching to ground water poses water quality concerns in some settings.	Water	34-39	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
22064289-6	2007	The textural properties and water-holding capacities of plasma and albumin gels were more pH-dependent than serum.	Water	28-33	albumin	Homo sapiens	67-74
17380484-1	2007	Molecular dynamics simulations reveal that the hydrophobic cavity in human cytokine Interleukin-1beta is hydrated and can dynamically accommodate between one and four water molecules.	Water	167-172	interleukin 1 beta	Homo sapiens	84-101
17552754-8	2007	They also used these and other hydrogen-bond definitions to examine the dynamics of local hydrogen-bond number fluctuations, finding an approximate long-time decay constant for SPC/E water of between 0.8 and 0.9 ps, which corresponds to the time scale for local structural relaxation.	Water	183-188	proline rich protein gene cluster	Homo sapiens	177-180
17645239-7	2007	These immunohistochemical results indicate that the expression not only of AQP4 but also of AQP1 was enhanced in MS and ischemic brain lesions located predominantly in astrocytes, suggesting a pivotal role of astrocytic AQP in the maintenance of water homeostasis in the CNS under pathological conditions.	Water	246-251	aquaporin 1 (Colton blood group)	Homo sapiens	92-96
21136710-1	2007	Human aquaporin-1 (AQP1) is the most studied member of the aquaporin family, acting as molecular water channel.	Water	97-102	aquaporin 1 (Colton blood group)	Homo sapiens	6-17
21136710-1	2007	Human aquaporin-1 (AQP1) is the most studied member of the aquaporin family, acting as molecular water channel.	Water	97-102	aquaporin 1 (Colton blood group)	Homo sapiens	19-23
17552754-7	2007	These two definitions lead to an estimate of the number of hydrogen bonds per molecule in liquid simple point charge/extended (SPC/E) water of between 3.2 and 3.4.	Water	134-139	proline rich protein gene cluster	Homo sapiens	127-130
17439167-0	2007	Folding of the 25 residue Abeta(12-36) peptide in TFE/water: temperature-dependent transition from a funneled free-energy landscape to a rugged one.	Water	54-59	amyloid beta precursor protein	Homo sapiens	26-31
17439167-6	2007	Finally, our simulations reveal that water and TFE solvate the polypeptide in different ways: The hydrogen bond formation between TFE and Abeta was enhanced with decreasing temperature, while that between water and Abeta was depressed.	Water	37-42	amyloid beta precursor protein	Homo sapiens	138-143
17439167-6	2007	Finally, our simulations reveal that water and TFE solvate the polypeptide in different ways: The hydrogen bond formation between TFE and Abeta was enhanced with decreasing temperature, while that between water and Abeta was depressed.	Water	37-42	amyloid beta precursor protein	Homo sapiens	215-220
17439264-1	2007	Potentials of mean force between single Na+, Ca2+, and Mg2+ cations and a highly charged spherical macroion in SPC/E water have been determined using molecular dynamics simulations.	Water	117-122	proline rich protein gene cluster	Homo sapiens	111-114
17439165-3	2007	Once SA1 is completed, the hydrophobic BD-QD building blocks are blended with amphiphilic block copolymer stabilizing chains in an organic solvent; water addition induces secondary self-assembly (SA2) to form quantum dot compound micelles (QDCMs).	Water	148-153	stromal antigen 1	Homo sapiens	5-8
17443264-1	2007	The intercalation of fac-tricarbonylchloro-1,10-phenanthrolinerhenium(i) (Re(phen)(CO)(3)Cl) within zirconium phosphate (ZrP) has been achieved using a hydrated ZrP phase that possesses six water molecules per formula unit.	Water	190-195	FA complementation group C	Homo sapiens	21-24
17485712-7	2007	Average 50-cm depth soil solution NO3- and ground water dissolved oxygen (DO) explained 64% of average cropland ground water NO3- variability.	Water	50-55	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
17485712-7	2007	Average 50-cm depth soil solution NO3- and ground water dissolved oxygen (DO) explained 64% of average cropland ground water NO3- variability.	Water	119-124	NBL1, DAN family BMP antagonist	Homo sapiens	34-37
17485712-7	2007	Average 50-cm depth soil solution NO3- and ground water dissolved oxygen (DO) explained 64% of average cropland ground water NO3- variability.	Water	119-124	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
17485712-8	2007	Cropland ground water with an average DO of &lt;3 mg L(-1) tended to have &lt;4 mg L(-1) of NO3- with a water table depth (WTD) of &lt;or=1 m. Water table depth and DO explained 83% of ground water NO3- variability among buffers.	Water	16-21	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
17485712-8	2007	Cropland ground water with an average DO of &lt;3 mg L(-1) tended to have &lt;4 mg L(-1) of NO3- with a water table depth (WTD) of &lt;or=1 m. Water table depth and DO explained 83% of ground water NO3- variability among buffers.	Water	104-109	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
17419625-0	2007	Secretory phospholipase A2 hydrolysis of phospholipid analogues is dependent on water accessibility to the active site.	Water	80-85	phospholipase A2 group X	Homo sapiens	0-26
17419625-6	2007	In the case of the phospholipids 1R, 2R, and 3S, our simulations revealed that the difference observed experimentally in sPLA2 activity might be caused by reduced access of water molecules to the active site.	Water	173-178	phospholipase A2 group X	Homo sapiens	121-126
17419625-7	2007	We have monitored the number of water molecules that enter the active site region for the different sPLA2-phospholipid complexes and found that the probability of a water molecule reaching the correct position such that hydrolysis can occur is reduced for the unnatural lipids.	Water	32-37	phospholipase A2 group X	Homo sapiens	100-105
17419625-7	2007	We have monitored the number of water molecules that enter the active site region for the different sPLA2-phospholipid complexes and found that the probability of a water molecule reaching the correct position such that hydrolysis can occur is reduced for the unnatural lipids.	Water	165-170	phospholipase A2 group X	Homo sapiens	100-105
17151143-4	2007	Consistent with these data, forced expression of MAPK phosphatase 1, a nuclear protein that dephosphorylates ERK1/2, in fast-twitch skeletal muscle ablated (P &lt; 0.05) the hypertrophic effects of BA feeding (clenbuterol, 20 parts per million in water) in vivo.	Water	247-252	mitogen-activated protein kinase 3	Homo sapiens	109-115
17526630-4	2007	Rats which were chronically treated with alcohol alone or in combination with nicotine, 0.3 mg/kg, showed an increase in ethanol intake when the free choice was performed between ethanol 10% and tap water; on the contrary, when the free choice was performed between ethanol 10% versus nicotine, 0.3 mg/kg, results showed a decrease in ethanol preference and a concomitant increase in nicotine preference.	Water	199-204	nuclear RNA export factor 1	Rattus norvegicus	195-198
17287200-1	2007	The vasopressin type 2 receptor (V2R) is a G protein-coupled receptor that plays a central role in renal water reabsorption.	Water	105-110	arginine vasopressin receptor 2	Homo sapiens	4-31
17166937-1	2007	The aquaporin (AQP)2 channel mediates the reabsorption of water in renal collecting ducts in response to arginine vasopressin (AVP) and hypertonicity.	Water	58-63	arginine vasopressin	Homo sapiens	114-125
17204593-7	2007	On the other hand, an early effect of water or saline consumption on VP secretion in PEG-treated rats was not observed, in contrast to recent findings in dehydrated rats.	Water	38-43	arginine vasopressin	Rattus norvegicus	69-71
17229678-2	2007	Vasopressin induces redistribution of Aqp2 from intracellular vesicles to the apical membrane of CD principal cells, accompanied by increased water permeability.	Water	142-147	arginine vasopressin	Homo sapiens	0-11
17229810-5	2007	Expression of aqp-2, aqp-3, aqp-4, aqp-6, or aqp-7 in Xenopus oocytes increased water permeability five- to sevenfold.	Water	80-85	aquaporin 2 S homeolog	Xenopus laevis	14-19
17229810-5	2007	Expression of aqp-2, aqp-3, aqp-4, aqp-6, or aqp-7 in Xenopus oocytes increased water permeability five- to sevenfold.	Water	80-85	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	21-26
17466712-1	2007	OBJECTIVE: Maternal water restriction (WR) may induce offspring plasma hypertonicity and enhanced vasopressin secretory responses.	Water	20-25	arginine vasopressin	Rattus norvegicus	98-109
17408294-3	2007	FB mixtures with water (0.075 wt %) were quite unstable and biphasic.	Water	17-22	fibrinogen beta chain	Homo sapiens	0-2
17287200-1	2007	The vasopressin type 2 receptor (V2R) is a G protein-coupled receptor that plays a central role in renal water reabsorption.	Water	105-110	arginine vasopressin receptor 2	Homo sapiens	33-36
16935571-1	2007	The passage of water through the aquaporin-1 (AQP1) transmembrane channel protein of the human erythrocyte is known to be inhibited by organic mercurials such as p-chloromercuribenzoate (pCMB), which react with the free SH-group of the critical cysteine (Cys189) located near the constriction of the AQP1 water-specific channel.	Water	15-20	aquaporin 1 (Colton blood group)	Homo sapiens	33-44
17494953-3	2007	We applied cigarette smoke water extract (CSE) to primary human lung fibroblasts and found that CSE significantly increased CXC chemokine IL-8 production.	Water	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
16935571-1	2007	The passage of water through the aquaporin-1 (AQP1) transmembrane channel protein of the human erythrocyte is known to be inhibited by organic mercurials such as p-chloromercuribenzoate (pCMB), which react with the free SH-group of the critical cysteine (Cys189) located near the constriction of the AQP1 water-specific channel.	Water	15-20	aquaporin 1 (Colton blood group)	Homo sapiens	46-50
17355118-2	2007	G1 PAMAM dendrimer-based prodrugs of the water-insoluble P-gp substrate terfenadine (Ter) were synthesized using succinic acid (suc) or succinyl-diethylene glycol (suc-deg) as a linker/spacer (to yield G1-suc-Ter and G1-suc-deg-Ter, respectively).	Water	41-46	ATP binding cassette subfamily B member 1	Homo sapiens	57-61
16935571-1	2007	The passage of water through the aquaporin-1 (AQP1) transmembrane channel protein of the human erythrocyte is known to be inhibited by organic mercurials such as p-chloromercuribenzoate (pCMB), which react with the free SH-group of the critical cysteine (Cys189) located near the constriction of the AQP1 water-specific channel.	Water	15-20	aquaporin 1 (Colton blood group)	Homo sapiens	300-304
16935571-1	2007	The passage of water through the aquaporin-1 (AQP1) transmembrane channel protein of the human erythrocyte is known to be inhibited by organic mercurials such as p-chloromercuribenzoate (pCMB), which react with the free SH-group of the critical cysteine (Cys189) located near the constriction of the AQP1 water-specific channel.	Water	305-310	aquaporin 1 (Colton blood group)	Homo sapiens	33-44
16935571-1	2007	The passage of water through the aquaporin-1 (AQP1) transmembrane channel protein of the human erythrocyte is known to be inhibited by organic mercurials such as p-chloromercuribenzoate (pCMB), which react with the free SH-group of the critical cysteine (Cys189) located near the constriction of the AQP1 water-specific channel.	Water	305-310	aquaporin 1 (Colton blood group)	Homo sapiens	46-50
16935571-1	2007	The passage of water through the aquaporin-1 (AQP1) transmembrane channel protein of the human erythrocyte is known to be inhibited by organic mercurials such as p-chloromercuribenzoate (pCMB), which react with the free SH-group of the critical cysteine (Cys189) located near the constriction of the AQP1 water-specific channel.	Water	305-310	aquaporin 1 (Colton blood group)	Homo sapiens	300-304
17329311-3	2007	Thus, it is not surprising that angiotensin II, which is synthesized in response to hypovolaemia, acts centrally to increase both water and NaCl intake.	Water	130-135	angiotensinogen	Homo sapiens	32-46
17453740-0	2007	Serum levels of the extracellular domain of the epidermal growth factor receptor in individuals exposed to arsenic in drinking water in Bangladesh.	Water	127-132	epidermal growth factor receptor	Homo sapiens	48-80
17453740-7	2007	In multiple regression analysis, serum EGFR ECD was found to be positively associated with three different measures of arsenic exposure (well water arsenic, urinary arsenic and a cumulative arsenic index) at statistically significant levels (p&lt;or=0.034), and this association was strongest among the individuals with arsenic-induced skin lesions (p &lt;or= 0.002).	Water	142-147	epidermal growth factor receptor	Homo sapiens	39-43
17278008-4	2007	The concentrations of BOD, turbidity, NO3 (-) and Fe in the water samples were above WHO and FMENV permissible limits for safe drinking water.	Water	60-65	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
17385903-6	2007	Compound 6 is not hydrolyzed by alkaline phosphatase (ALP), whereas 5 is highly soluble (mg/mL) in aqueous solution and is rapidly dephosphorylated in the presence of ALP to 1, a water-insoluble molecule (ng/mL).	Water	179-184	alkaline phosphatase, placental	Homo sapiens	167-170
17342175-2	2007	Catalase is a highly conserved heme-containing protein that reduces hydrogen peroxide to water and oxygen and is an important factor decreasing cellular injury owing to oxidative stress.	Water	89-94	catalase	Mus musculus	0-8
17464433-1	2007	Central angiotensin II (AngII) stimulates water and salt solution intake.	Water	42-47	angiotensinogen	Rattus norvegicus	8-22
17464433-1	2007	Central angiotensin II (AngII) stimulates water and salt solution intake.	Water	42-47	angiotensinogen	Rattus norvegicus	24-29
17633169-4	2007	Concentrations distributions of dissolved inorganic nitrogen (DIN) and NO3- -N in overlying water varied seasonally, which got their maximum concentration in October 2004 while the NH4+ -N concentration showed a little difference.	Water	92-97	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
17633169-5	2007	The seasonal change of dissolved inorganic nitrogen (DIN) and NO3- -N, NH4+ -N in interstitial water varied similarly and also got their maximum concentration in October 2004.	Water	95-100	NBL1, DAN family BMP antagonist	Homo sapiens	62-65
17389737-3	2007	The success of desmopressin, a synthetic analogue of the antidiuretic hormone vasopressin, has been attributed to increased renal water reabsorption that is mediated by activation of the renal vasopressin V2 receptor (V2R).	Water	130-135	arginine vasopressin	Homo sapiens	78-89
17389737-3	2007	The success of desmopressin, a synthetic analogue of the antidiuretic hormone vasopressin, has been attributed to increased renal water reabsorption that is mediated by activation of the renal vasopressin V2 receptor (V2R).	Water	130-135	arginine vasopressin receptor 2	Homo sapiens	193-216
17409310-5	2007	A severe urinary concentration defect in slc4a1-/- mice was accompanied by dysregulated expression and localization of the aquaporin-2 water channel.	Water	135-140	solute carrier family 4 (anion exchanger), member 1	Mus musculus	41-47
17376456-8	2007	Reproducibility with RSD less than 9.7% for extractions of real water samples at microg l(-1) or ngl(-1) level was obtained.	Water	64-69	leucine rich repeat containing 4C	Homo sapiens	97-103
17425719-1	2007	The gaseous pollutant SO(2) readily reacts with water to form sulfite that impacts deleteriously on animal and plant health.	Water	48-53	sulfite oxidase	Arabidopsis thaliana	22-24
17464051-5	2007	The antioxidant activities of catalase and glutathione reductase were triggered by moderate oxidative exposure (5 mM H(2)O(2)), whereas superoxide dismutase was inhibited dramatically by H(2)O(2), where a more marked decrease was observed in atc1Delta cells.	Water	117-122	catalase	Mus musculus	30-38
17156580-1	2007	Urinary schistosomiasis is an important source of human morbidity in Msambweni, Kenya, where the intermediate host snail, Bulinus nasutus is found in ponds and water pools.	Water	160-165	snail family transcriptional repressor 1	Homo sapiens	115-120
17388586-1	2007	A new carboxylato-bridged CoII network of formula {Co((kappa1-kappa1)-(kappa1-mu2)-mu4-TDC)(mu2-H2O)0.5(H2O)}n (H2TDC=2,5-thiophenedicarboxylic acid) has been hydrothermally synthesized and characterized by single-crystal X-ray diffraction, thermogravimetric analysis, and IR and UV-visible spectroscopies.	Water	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
17388586-1	2007	A new carboxylato-bridged CoII network of formula {Co((kappa1-kappa1)-(kappa1-mu2)-mu4-TDC)(mu2-H2O)0.5(H2O)}n (H2TDC=2,5-thiophenedicarboxylic acid) has been hydrothermally synthesized and characterized by single-crystal X-ray diffraction, thermogravimetric analysis, and IR and UV-visible spectroscopies.	Water	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
17346701-2	2007	In the present study we show that expression of the human water channel aquaporin-9 (AQP9) in different cell lines induces the formation of numerous filopodial extensions.	Water	58-63	aquaporin 9	Homo sapiens	72-83
17313987-1	2007	We examined the potential application of a non-viral gene carrier, water soluble lipopolymer (WSLP) for delivering siRNA targeting vascular endothelial growth factor (VEGF) in vitro and in vivo.	Water	67-72	vascular endothelial growth factor A	Homo sapiens	131-165
17313987-1	2007	We examined the potential application of a non-viral gene carrier, water soluble lipopolymer (WSLP) for delivering siRNA targeting vascular endothelial growth factor (VEGF) in vitro and in vivo.	Water	67-72	vascular endothelial growth factor A	Homo sapiens	167-171
17394303-8	2007	Both models assume that initiation of colipase adsorption to the water/lipid interface requires an area of water-exposed hydrophobic surface that exceeds a critical value.	Water	65-70	colipase	Homo sapiens	38-46
17394303-8	2007	Both models assume that initiation of colipase adsorption to the water/lipid interface requires an area of water-exposed hydrophobic surface that exceeds a critical value.	Water	107-112	colipase	Homo sapiens	38-46
17381142-2	2007	The interactions of the metal oxide in the simulations were described by a recently developed classical force field based on the SPC/E model of water.	Water	144-149	proline rich protein gene cluster	Homo sapiens	129-132
17397663-1	2007	Trihalogenated anisoles (THAs) that have been identified at low concentration levels (ngL(-1)) in drinking water are suspected of causing odor episodes, which are a frequent source of complaint by consumers.	Water	107-112	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-89
17346701-2	2007	In the present study we show that expression of the human water channel aquaporin-9 (AQP9) in different cell lines induces the formation of numerous filopodial extensions.	Water	58-63	aquaporin 9	Homo sapiens	85-89
17346701-9	2007	We propose that increased water influx through AQP9 is critically involved in the formation of membrane protrusions, and that AQP9-induced actin polymerization is augmented by activation of Cdc42 and PKC(zeta).	Water	26-31	aquaporin 9	Homo sapiens	47-51
17346701-9	2007	We propose that increased water influx through AQP9 is critically involved in the formation of membrane protrusions, and that AQP9-induced actin polymerization is augmented by activation of Cdc42 and PKC(zeta).	Water	26-31	aquaporin 9	Homo sapiens	126-130
17407569-10	2007	We suggest that the experimental differences in binding energetics can be at least partially ascribed to the absence in the R21A Spc-SH3:P41 complex of several buried water molecules, which have been proposed previously to contribute largely to the highly negative enthalpy and entropy of binding in the Abl-SH3:P41 complex.	Water	167-172	mitogen-activated protein kinase 1	Homo sapiens	137-140
17533826-4	2007	Acidic water-soluble heteroatomic classes detected at &gt;1% relative abundance include O, O2, O3, O4, OS, O2S, O3S, O4S, NO2, NO3, and NO4.	Water	7-12	NBL1, DAN family BMP antagonist	Homo sapiens	127-130
17533826-8	2007	Water-soluble heteroatomic basic classes detected at &gt;1% relative abundance include N, NO, NO2, NS, NS2, NOS, NO2S, N2, N2O, N2O2, OS, O2S, and O2S2.	Water	0-5	NS2	Homo sapiens	103-106
17074436-0	2007	Solid phase extraction method for selective determination of Pb(II) in water samples using 4-(4-methoxybenzylidenimine) thiophenole.	Water	71-76	submaxillary gland androgen regulated protein 3B	Homo sapiens	61-67
17407569-10	2007	We suggest that the experimental differences in binding energetics can be at least partially ascribed to the absence in the R21A Spc-SH3:P41 complex of several buried water molecules, which have been proposed previously to contribute largely to the highly negative enthalpy and entropy of binding in the Abl-SH3:P41 complex.	Water	167-172	mitogen-activated protein kinase 1	Homo sapiens	312-315
17407569-11	2007	CONCLUSION: Based on a deep structural and thermodynamic analysis of a low and high affinity complex of two different SH3 domains with the same ligand p41, we underline the importance of taking into account in any effective strategy of rational design of ligands, factors different from the direct protein-ligand interactions, such as the mediation of interactions by water molecules or the existence of cooperative conformational effects induced by binding.	Water	368-373	mitogen-activated protein kinase 1	Homo sapiens	151-154
17079781-3	2007	Previously we demonstrated that in cultured mouse lung epithelial cells exposed to bolus administration of H(2)O(2), TNF-alpha-induced NF-kappaB activity was inhibited, whereas c-Jun-N-terminal kinase (JNK) activation was enhanced via a mechanism involving TNF receptor-1 (TNF-RI).	Water	107-112	tumor necrosis factor	Mus musculus	117-126
17108007-7	2007	An inhibitor of ERKs, but not phosphoinositide 3-kinase or p38 MAPKs, blocked NFAT3 activation by H(2)O(2).	Water	98-103	mitogen-activated protein kinase 1	Homo sapiens	16-20
17108007-7	2007	An inhibitor of ERKs, but not phosphoinositide 3-kinase or p38 MAPKs, blocked NFAT3 activation by H(2)O(2).	Water	98-103	nuclear factor of activated T cells 3	Homo sapiens	78-83
17108007-9	2007	ERK inhibitor PD98059 was found previously to inhibit AP-1 activation by H(2)O(2).	Water	73-78	mitogen-activated protein kinase 1	Homo sapiens	0-3
17267016-0	2007	Removal of dinitrotoluenes from water via reduction with iron and peroxidase-catalyzed oxidative polymerization: a comparison between Arthromyces ramosus peroxidase and soybean peroxidase.	Water	32-37	peroxidase	Glycine max	66-76
17035279-7	2007	In addition, iNOS was colocalised with cytochrome c oxidase on day 5 of EAU.	Water	72-75	nitric oxide synthase 2	Rattus norvegicus	13-17
17267016-1	2007	A two-step process for the removal of dinitrotoluene from water is presented: zero-valent iron reduction is coupled with peroxidase-catalyzed polymerization of the resulting diaminotoluenes (DAT).	Water	58-63	peroxidase	Glycine max	121-131
17430242-5	2007	Here we show that in a setting of elevated cholesterol levels, overproduced Abeta is cleared to the blood and can simultaneously be identified in the liver if copper ion is absent from the animal"s drinking water, but if trace levels copper (0.12 PPM) are added to the drinking water Abeta accumulates in the brain, while the levels in the liver are greatly reduced.	Water	207-212	amyloid beta precursor protein	Homo sapiens	76-81
17300772-5	2007	The combination of 100 micromol/l Hcy with 4 micromol/l SAH (SAH+Hcy) significantly increased intracellular H(2)O(2), and the DNA damage induced by SAH+Hcy was strongly inhibited by addition of superoxide dismutase, catalase or desferrioxamine, suggesting the involvement of reactive oxygen species.	Water	108-113	acyl-CoA synthetase medium-chain family member 3	Mus musculus	61-68
17430242-5	2007	Here we show that in a setting of elevated cholesterol levels, overproduced Abeta is cleared to the blood and can simultaneously be identified in the liver if copper ion is absent from the animal"s drinking water, but if trace levels copper (0.12 PPM) are added to the drinking water Abeta accumulates in the brain, while the levels in the liver are greatly reduced.	Water	278-283	amyloid beta precursor protein	Homo sapiens	76-81
17120021-9	2007	Water molecules follow across the epithelium mainly through the water channel, AQP1, driven by the created ionic gradient.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	79-83
17495413-2	2007	Absorption enhancers, such as sodium caprate (C10), decanoylcarnitine (DC) and tartaric acid (TA), increased the paracellular permeability of water-soluble, low lipophilic and poorly absorbable drugs by enlargement of tight junction (TJ) adhering to the intercellular portion; that is, expansion of the paracellular routes.	Water	142-147	homeobox C10	Homo sapiens	46-49
17458180-4	2007	Mutations of the vasopressin-regulated water channel on the principal cells of the collecting duct, namely aquaporin (AQP)2, account for a minority of cases of congenital NDI.	Water	39-44	arginine vasopressin	Homo sapiens	17-28
17283064-0	2007	Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption.	Water	102-107	secretin receptor	Mus musculus	24-41
17283064-5	2007	Additionally, SCTR(-/-) mice were shown to have reduced renal expression of AQP2 and AQP4, as well as altered glomerular and tubular morphology, suggesting possible disturbances in the filtration and/or water reabsorption process in these animals.	Water	203-208	secretin receptor	Mus musculus	14-18
17120021-9	2007	Water molecules follow across the epithelium mainly through the water channel, AQP1, driven by the created ionic gradient.	Water	64-69	aquaporin 1 (Colton blood group)	Homo sapiens	79-83
17583206-5	2007	RESULT: Two kinds of water abstract induced significantly renal injury in rats, IL-1beta, IL-6 levels in renal homogenate were significantly increased compared with controls, histological section showed inflammatory cell infiltration play important role in renal tubulointerstitium damage.	Water	21-26	interleukin 1 beta	Rattus norvegicus	80-88
17551845-1	2007	Bundle sheath chloroplasts of NADP-malic enzyme (NADP-ME) type C4 species have a high demand for ATP, while being deficient in linear electron flow and oxidation of water by photosystem II (PSII).	Water	165-170	NADP-dependent malic enzyme	Zea mays	30-47
17551845-1	2007	Bundle sheath chloroplasts of NADP-malic enzyme (NADP-ME) type C4 species have a high demand for ATP, while being deficient in linear electron flow and oxidation of water by photosystem II (PSII).	Water	165-170	NADP-dependent malic enzyme	Zea mays	49-56
17583206-5	2007	RESULT: Two kinds of water abstract induced significantly renal injury in rats, IL-1beta, IL-6 levels in renal homogenate were significantly increased compared with controls, histological section showed inflammatory cell infiltration play important role in renal tubulointerstitium damage.	Water	21-26	interleukin 6	Rattus norvegicus	90-94
17335258-0	2007	Delivery of both active enzyme and bleach from water-in-silicone oil (D(4)) emulsions.	Water	47-52	Rho GDP dissociation inhibitor beta	Homo sapiens	69-74
17302434-5	2007	Compared to other members of the ALDH family, FDH demonstrates a new mode of binding of the 2"-phosphate group of NADP via a water-mediated contact with Gln600 that may contribute to the specificity of the enzyme for NADP over NAD.	Water	125-130	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	46-49
17461471-7	2007	CONCLUSION: Our results suggest that upregulation of AQP8 in the colon of UC patients represents a secondary phenomenon which may, due to altered water exchange of the distal intestinal mucosa, disturb the physiologic colonic mucus barrier and thus lead to chronic inflammation and ulceration.	Water	146-151	aquaporin 8	Homo sapiens	53-57
17386766-0	2007	A quantitative method for determination of Co(II) based on the inner filter effect of reagents on the Raman scattering signals of water.	Water	130-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
17239399-1	2007	Aquaporin-9, an aquaglyceroporin present in diverse tissues, is unique among aquaporins because it is not only permeable to water, urea and glycerol, but also allows passage of larger uncharged solutes.	Water	124-129	aquaporin 9	Rattus norvegicus	0-11
17339489-7	2007	The stimulatory role was confirmed by the observation that 12.5 microM H(2)O(2), a concentration found during inflammation, increased the expression of several proinflammatory NF-kappaB-dependent genes induced by TNF-alpha (e.g., IL-8, MCP-1, TLR2, and TNF-alpha).	Water	71-77	toll like receptor 2	Homo sapiens	243-247
16889893-4	2007	We found that the pHs in run-off and in percolate water from the pilot experiment are both around neutral.	Water	50-55	pterin-4 alpha-carbinolamine dehydratase 1	Homo sapiens	18-21
17448269-6	2007	The expression of p-ERK peaked at 30 minutes after stimulation by 500 micromol/L H(2)O(2).	Water	81-86	Eph receptor B1	Rattus norvegicus	20-23
17339489-7	2007	The stimulatory role was confirmed by the observation that 12.5 microM H(2)O(2), a concentration found during inflammation, increased the expression of several proinflammatory NF-kappaB-dependent genes induced by TNF-alpha (e.g., IL-8, MCP-1, TLR2, and TNF-alpha).	Water	71-77	nuclear factor kappa B subunit 1	Homo sapiens	176-185
17339489-7	2007	The stimulatory role was confirmed by the observation that 12.5 microM H(2)O(2), a concentration found during inflammation, increased the expression of several proinflammatory NF-kappaB-dependent genes induced by TNF-alpha (e.g., IL-8, MCP-1, TLR2, and TNF-alpha).	Water	71-77	tumor necrosis factor	Homo sapiens	213-222
17339489-7	2007	The stimulatory role was confirmed by the observation that 12.5 microM H(2)O(2), a concentration found during inflammation, increased the expression of several proinflammatory NF-kappaB-dependent genes induced by TNF-alpha (e.g., IL-8, MCP-1, TLR2, and TNF-alpha).	Water	71-77	tumor necrosis factor	Homo sapiens	253-262
17339489-7	2007	The stimulatory role was confirmed by the observation that 12.5 microM H(2)O(2), a concentration found during inflammation, increased the expression of several proinflammatory NF-kappaB-dependent genes induced by TNF-alpha (e.g., IL-8, MCP-1, TLR2, and TNF-alpha).	Water	71-77	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
17291015-8	2007	Within this subgroup of polymers, there was a strong correlation between decreasing air-water contact angles and decreasing fibrinogen adsorption (R2 = 0.95).	Water	88-93	fibrinogen beta chain	Homo sapiens	124-134
17822232-5	2007	The proposed method has been applied to the direct detection of Co(II) in surface water and wastewater with good percent of recovery.	Water	82-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
17298039-4	2007	It is found that two bridging water molecules with two discrete DFT-based effective fragment potential solvent waters at the MP2/6-31G(d,p) level of ab initio theory provides the most computationally effective model for solvent effects in this system.	Water	30-35	major intrinsic protein of lens fiber	Homo sapiens	125-130
17298039-4	2007	It is found that two bridging water molecules with two discrete DFT-based effective fragment potential solvent waters at the MP2/6-31G(d,p) level of ab initio theory provides the most computationally effective model for solvent effects in this system.	Water	111-117	major intrinsic protein of lens fiber	Homo sapiens	125-130
17197696-7	2007	Its C-terminal heme-containing region showed the highest sequence identity to the water-soluble cytochrome c(2), although its predicted secondary structure resembles that of cytochrome c(y).	Water	82-87	cytochrome c, somatic	Homo sapiens	96-108
17197696-7	2007	Its C-terminal heme-containing region showed the highest sequence identity to the water-soluble cytochrome c(2), although its predicted secondary structure resembles that of cytochrome c(y).	Water	82-87	cytochrome c, somatic	Homo sapiens	174-186
17197696-12	2007	It was concluded that either the membrane-bound cytochrome c(2m) or the water-soluble cytochrome c(2) work as a physiological electron carrier in the photosynthetic electron transfer pathway of Rvu.	Water	72-77	cytochrome c, somatic	Homo sapiens	86-98
17110522-1	2007	Our previous work supports a role for aquaporin-8 (AQP8) water channels in rat hepatocyte bile formation mainly by facilitating the osmotically driven canalicular secretion of water.	Water	57-62	aquaporin 8	Rattus norvegicus	38-49
17110522-1	2007	Our previous work supports a role for aquaporin-8 (AQP8) water channels in rat hepatocyte bile formation mainly by facilitating the osmotically driven canalicular secretion of water.	Water	57-62	aquaporin 8	Rattus norvegicus	51-55
17110522-1	2007	Our previous work supports a role for aquaporin-8 (AQP8) water channels in rat hepatocyte bile formation mainly by facilitating the osmotically driven canalicular secretion of water.	Water	176-181	aquaporin 8	Rattus norvegicus	38-49
17110522-1	2007	Our previous work supports a role for aquaporin-8 (AQP8) water channels in rat hepatocyte bile formation mainly by facilitating the osmotically driven canalicular secretion of water.	Water	176-181	aquaporin 8	Rattus norvegicus	51-55
17110522-7	2007	Osmotic water permeability (P(f)) of canalicular membranes, measured by stopped-flow spectrophotometry, was significantly reduced (73 +/- 1 vs. 57 +/- 2 microm/s) in cholestasis, consistent with defective canalicular AQP8 functional expression.	Water	8-13	aquaporin 8	Rattus norvegicus	217-221
17110522-11	2007	Reduced canalicular membrane AQP8 expression is associated with impaired osmotic membrane water permeability.	Water	90-95	aquaporin 8	Rattus norvegicus	29-33
17822232-0	2007	Determination of cobalt at ng ml(-1) level in water using the electrophilic substiution complexation between co(II) and chlorophosphonazo-p-CL-Cu(II) complex.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
17270166-1	2007	Secretory phospholipase A2 (sPLA2) represents a family of small water-soluble enzymes that catalyze the hydrolysis of phospholipids in the sn-2 position liberating free fatty acids and lysophospholipids.	Water	64-69	phospholipase A2 group X	Homo sapiens	0-26
17178102-5	2007	Single water permeability (pf) of AQP11 was measured to be 1.72+/-0.03x10(-13) cm(3)/s, suggesting that other members of the subfamily with incompletely conserved NPA motifs may also function as water channels.	Water	7-12	aquaporin 11	Homo sapiens	34-39
17465218-7	2007	CONCLUSION: This study indicates that the major water-soluble choline metabolite was phosphocholine (PCho) as a consequence of increased ChoK and PLD activity in the exponentially growing cells compared to confluent cells.	Water	48-53	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	146-149
17020896-9	2007	After stimulated with H(2)O(2), NF-kappaB was found translocated from cytoplasm into the nuclei.	Water	22-27	nuclear factor kappa B subunit 1	Homo sapiens	32-41
17188323-5	2007	For example, for the case of bentonitic soils characterized by a Pb(II) concentration in the solid phase equal to 954.4 mg kg(-1), leachable Pb(II) was reduced, after 7 h of mechanical treatment, from 1.3 mg l(-1) to a concentration lower than the USEPA regulatory threshold (i.e., 0.015 mg l(-1) for drinkable water).	Water	311-316	submaxillary gland androgen regulated protein 3B	Homo sapiens	65-71
17188323-5	2007	For example, for the case of bentonitic soils characterized by a Pb(II) concentration in the solid phase equal to 954.4 mg kg(-1), leachable Pb(II) was reduced, after 7 h of mechanical treatment, from 1.3 mg l(-1) to a concentration lower than the USEPA regulatory threshold (i.e., 0.015 mg l(-1) for drinkable water).	Water	311-316	submaxillary gland androgen regulated protein 3B	Homo sapiens	141-147
17270166-1	2007	Secretory phospholipase A2 (sPLA2) represents a family of small water-soluble enzymes that catalyze the hydrolysis of phospholipids in the sn-2 position liberating free fatty acids and lysophospholipids.	Water	64-69	phospholipase A2 group X	Homo sapiens	28-33
17273783-0	2007	Comano"s (Trentino) thermal water interferes with tumour necrosis factor-alpha expression and interleukin-8 production and secretion by cultured human psoriatic keratinocytes: yet other mechanisms of its anti-psoriatic action.	Water	28-33	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
17396641-8	2007	Tap water bottled commercially in PET(E) in December 2005 contained 450+/-56 ng/L Sb (n = 3) versus 70.3+/-0.3 ng/L Sb (n = 3) when sampled from a household faucet in the same village (Bammental, Germany), and 25.7+/-1.5 ng/L Sb (n = 3) from a local artesian flow.	Water	4-9	SEC14 like lipid binding 2	Homo sapiens	0-3
17084069-2	2007	In this paper, the characteristics and the mechanism governing the in vitro release of a model water-soluble drug, vitamin B12, from these polymer vehicles were determined.	Water	95-100	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	123-126
17314256-6	2007	Furthermore, human monocytes stimulated by water-insoluble alpha-glucans produced TNF-alpha and IL-8, while human polymorphonuclear cells were activated by water-insoluble alpha-glucans, resulting in chemotaxis and hydrogen peroxide production.	Water	43-48	tumor necrosis factor	Homo sapiens	82-91
17314256-6	2007	Furthermore, human monocytes stimulated by water-insoluble alpha-glucans produced TNF-alpha and IL-8, while human polymorphonuclear cells were activated by water-insoluble alpha-glucans, resulting in chemotaxis and hydrogen peroxide production.	Water	43-48	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
17374283-6	2007	CONCLUSIONS: The decreased AQP8 expression in D-IBS patients indicates that dysfunction of colonic absorption may cause reduced water absorption, loose stool and diarrhoea.	Water	128-133	aquaporin 8	Homo sapiens	27-31
17460545-10	2007	Wild type CYP26A1 protein metabolized all-trans-retinoic acid (at-RA) to 4-oxo-RA, 4-OH-RA as well as water-soluble metabolites.	Water	102-107	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	10-17
17598476-1	2007	Principal mechanism of the transepithelial water permeability increase in the kidney collecting ducts in response to vasopressin involves insertion of aquaporin 2 (AQP2) into the apical membrane.	Water	43-48	arginine vasopressin	Rattus norvegicus	117-128
17126611-5	2007	Superoxide dismutase (SOD; converts superoxide to H(2)O(2)) significantly reduced the contraction in both types of arteries -- an effect abolished by catalase (H(2)O(2) scavenger), suggesting that the SOD effect was mediated by H(2)O(2).	Water	50-55	catalase	Rattus norvegicus	150-158
17309209-9	2007	In the Co(TPMCP) Langmuir films formed on the water subphases, Co(II) was complexed by aromatic but not cyclic heteroaliphatic ligands, while, in these films formed on the NaCl subphase solutions, the metalloporphyrin was also complexed by DABCO.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
17256924-4	2007	Concentration-dependent, PLAP-mediated conversion of IQ2-P,4-P (4)/125IQ2-P,4-P (6) to water-insoluble 2-(2",4"-dihydroxyphenyl)-6-[127I/125I]iodo-4-(3H)-quinazolinone (127IQ2-OH,4-OH (2)/125IQ2-OH,4-OH (7)) was observed in solution.	Water	87-92	alkaline phosphatase, placental	Homo sapiens	25-29
17274647-4	2007	The density of states (DOS) of alpha-CL-20.H2O is somewhat different from those of the other three crystals for its inclusion of H2O molecules that contribute the frontier energy bands.	Water	43-46	epithelial membrane protein 1	Homo sapiens	37-42
17274647-4	2007	The density of states (DOS) of alpha-CL-20.H2O is somewhat different from those of the other three crystals for its inclusion of H2O molecules that contribute the frontier energy bands.	Water	129-132	epithelial membrane protein 1	Homo sapiens	37-42
17274647-6	2007	According to the calculated values of band gaps, the sensitivity of the four polymorphs of CL-20 is predicted as epsilon &lt; beta &lt; gamma &lt; alpha.H2O, which agrees well with the experimental result.	Water	153-156	epithelial membrane protein 1	Homo sapiens	91-96
17261004-2	2007	[reaction: see text] In the absence of water, an excess of the lithium enolate of N-(diphenylmethylene)glycine ethyl ester (4) adds to sulfinimines to give syn-2,3-diamino esters 6, and in the presence of water, this enolate gives the anti-2,3-diamino esters 5.	Water	205-210	synapsin II	Homo sapiens	156-161
17266358-2	2007	Adding water to the organic phase, the SN2 yield increases in the cost of decreased reactivity.	Water	7-12	solute carrier family 38 member 5	Homo sapiens	39-42
17211597-2	2007	The extraction, clean-up, and analytical procedures were optimized for both water and soil samples to provide a highly robust method capable of determining target analytes at the ppb-ppt level with high precision.	Water	76-81	tachykinin precursor 1	Homo sapiens	183-186
17311087-8	2007	We showed that all Elovl4-/- mice exhibited defective skin water permeability barrier function, leading to the early postnatal death.	Water	59-64	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	19-25
17311087-10	2007	These data demonstrate that ELOVL4 is required for VLCFA synthesis that is essential for water permeability barrier function of skin.	Water	89-94	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	28-34
16985212-1	2007	We recently identified a novel phosphorylation site, serine-261 (pS261), in the COOH-terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2).	Water	123-128	arginine vasopressin	Rattus norvegicus	101-112
17284834-3	2007	The water eluate (fraction A) showed an augmenting effect on anti-ovalbumin (anti-OVA) immunoglobulin M (IgM) production in OVA-stimulated murine splenocytes in vitro.	Water	4-9	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	66-75
17098798-4	2007	Here we study VASP-mediated actin-related proteins 2/3 (Arp2/3) complex-dependent actin dynamics using a substrate that mimics the fluid properties of the cell membrane: an oil-water interface.	Water	177-182	Actin 79B	Drosophila melanogaster	82-87
16870505-4	2007	Analysis of experimental data on intramolecular radioactivity distribution in lysozyme and computer simulation of tritium bombardment allowed us to suggest two equally probable opposite orientations of lysozyme molecule in the adsorption layer at the air-water interface.	Water	255-260	lysozyme	Homo sapiens	202-210
17217943-2	2007	The permeability to water (microm/min/atm) of immature oocytes at 25 degrees C (0.37) was significantly higher than that of mature oocytes (0.10).	Water	20-25	ATM serine/threonine kinase	Danio rerio	38-41
17095038-2	2007	These reduction reactions may play a role in DBP fate in iron water mains and potentially could be exploited to remove DBPs from drinking water or wastewater in a packed-bed configuration.	Water	62-67	D-box binding PAR bZIP transcription factor	Homo sapiens	45-48
17095038-3	2007	Oxidants (i.e., dissolved oxygen (DO) and chlorine) present in the water, however, may decrease the DBP degradation rate by competing for reactive sites and rapidly aging or corroding the iron surface.	Water	67-72	D-box binding PAR bZIP transcription factor	Homo sapiens	100-103
17514966-2	2007	The CD results show that pure bovine serum albumin is composed of 56.8% alpha-helices, 5.8% beta-sheets, 14.1% beta-turns and 23.9% random structures, while the bovine serum albumin in the Ca10(PO4)6(OH)2/bovine serum albumin solution is composed of 25.4% alpha-helices, 25.0% beta-sheets, 20.0% beta-turns and 29.7% random structures.	Water	200-204	albumin	Homo sapiens	168-181
16741709-3	2007	Here, we show that early LPS-activated bone marrow derived DC (early DC, eDC), when administered subcutaneously to mice in vivo, promote tolerance to EAU induced via immunisation with interphotoreceptor retinol binding protein (IRBP) peptide 161-180.	Water	150-153	toll-like receptor 4	Mus musculus	25-28
17514966-2	2007	The CD results show that pure bovine serum albumin is composed of 56.8% alpha-helices, 5.8% beta-sheets, 14.1% beta-turns and 23.9% random structures, while the bovine serum albumin in the Ca10(PO4)6(OH)2/bovine serum albumin solution is composed of 25.4% alpha-helices, 25.0% beta-sheets, 20.0% beta-turns and 29.7% random structures.	Water	200-204	albumin	Homo sapiens	168-181
17287564-4	2007	Mean-while, water loss results in increased activities of reactive-oxygen-scavenging enzymes (SOD, CAT, APX and GR).	Water	12-17	catalase	Homo sapiens	99-102
17097100-9	2007	The method has application in estimating the de-pin time of a droplet deposited on a substrate that yields poor top-view contrast for videography, such as a water droplets on silicon wafers or glass substrates.	Water	157-162	dynein light chain LC8-type 1	Homo sapiens	48-51
17214873-9	2007	Ang II-induced water and 2% NaCl intake in behaving adult male, Fischer rats, as well as preoptic/medial septum region neuronal responses to Ang II and losartan, using a seven-barrelled micro-iontophoretic electrode sealed to a recording electrode in urethane anaesthetised, male Fischer rats.	Water	15-20	angiotensinogen	Rattus norvegicus	0-6
17230585-5	2007	As compared to placebo fecal water, beta-glucan enriched fecal water significantly increased IL-8 production in HT29 (5.0%; p = 0.046) and INT407 cells (22.0%; p = 0.028).	Water	63-68	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
17106904-4	2007	In water solution, Bax-alpha1 is present as a mixture of beta-sheet and unstructured (random coil) conformations.	Water	3-8	BCL2 associated X, apoptosis regulator	Homo sapiens	19-22
17227015-5	2007	Energetic analysis at the MP2 level in the gas phase supported stronger Meimid binding over H2O binding to both UO2(Ac)2 and UO2(NO3)2.	Water	92-95	adenylate cyclase 2	Homo sapiens	112-120
17227015-5	2007	Energetic analysis at the MP2 level in the gas phase supported stronger Meimid binding over H2O binding to both UO2(Ac)2 and UO2(NO3)2.	Water	92-95	NBL1, DAN family BMP antagonist	Homo sapiens	129-132
17227015-7	2007	For both UO2(NO3)2 and UO2(Ac)2, the displacement of H2O by Meimid was predicted to be energetically favorable, consistent with experimental results that suggest Meimid may bind uranyl at physiological pH.	Water	53-56	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
17227015-7	2007	For both UO2(NO3)2 and UO2(Ac)2, the displacement of H2O by Meimid was predicted to be energetically favorable, consistent with experimental results that suggest Meimid may bind uranyl at physiological pH.	Water	53-56	adenylate cyclase 2	Homo sapiens	23-31
17198433-5	2007	The crystal structure of Mn2(ENOTA)(H2O) x 5H2O contains two six-coordinated Mn2+, in addition to the three amine nitrogens and the two oxygens from the pendent monodentate carboxylate groups, and one water (Mn2) or one bridging carboxylate oxygen (Mn1) completes the coordination sphere of the metal ion.	Water	36-40	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	249-252
32680262-1	2007	Blood triglyceride, free fatty acid and insulin levels are lower after acute intake of an oil-water-monoglyceride gel versus an oil-water mixture, demonstrating that food matrix nanostructure and microstructure can be engineered to modulate the physiological response.	Water	94-99	insulin	Homo sapiens	40-47
17141196-3	2007	Unexpectedly, we found that water-soluble lactostatin can activate cholesterol 7alpha-hydroxylase (CYP7A1) gene expression.	Water	28-33	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	67-97
17141196-3	2007	Unexpectedly, we found that water-soluble lactostatin can activate cholesterol 7alpha-hydroxylase (CYP7A1) gene expression.	Water	28-33	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	99-105
17123487-2	2007	Expression levels of the water channels aquaporin 1 and aquaporin 4 (AQP1, AQP4) were examined in AD cases by gel electrophoresis and Western blotting, and densitometric values normalized with beta-actin were compared with corresponding values in age-matched controls processed in parallel.	Water	25-30	aquaporin 1 (Colton blood group)	Homo sapiens	40-51
17123487-2	2007	Expression levels of the water channels aquaporin 1 and aquaporin 4 (AQP1, AQP4) were examined in AD cases by gel electrophoresis and Western blotting, and densitometric values normalized with beta-actin were compared with corresponding values in age-matched controls processed in parallel.	Water	25-30	aquaporin 1 (Colton blood group)	Homo sapiens	69-73
17123487-10	2007	These results indicate abnormal expression of AQP1 in astrocytes in AD, and they add support to the idea that abnormal regulation of mechanisms involved in the control of water fluxes occurs at early stages in AD.	Water	171-176	aquaporin 1 (Colton blood group)	Homo sapiens	46-50
17198412-1	2007	We have recently reported that aquo and thioether complexes of the ferric cytochrome c heme peptide N-acetylmicroperoxidase-8 (FeIII-1) exhibit greater low-spin character than do the corresponding complexes of a synthetic, water-soluble, monohistidine-ligated heme peptide (FeIII-2; Cowley, A.	Water	223-228	cytochrome c, somatic	Homo sapiens	74-86
17215371-3	2007	Based on quantum mechanics/molecular mechanics (QM/MM) calculations, the free energy for MeOH reduction of o-PQQ when MeOH is hydrogen bonded to Glu-171-CO(2)(-) and the crystal water (Wat1) is hydrogen bonded to Asp-297-CO(2)(-) is DeltaG++ = 11.7 kcal/mol, which is comparable with the experimental value of 8.5 kcal/mol.	Water	178-183	MTOR associated protein, LST8 homolog	Homo sapiens	185-189
17215371-6	2007	Molecular dynamics (MD) simulations on MDH.PQQ.Wat1 complex in TIP3P water for 5 ns does not result in interchange of Asp-297-CO(2)(-) bound Wat1 for a solvent water.	Water	69-74	MTOR associated protein, LST8 homolog	Homo sapiens	47-51
17179207-6	2007	Akt activation was facilitated by mitochondrial binding of CO and by production of hydrogen peroxide (H(2)O(2)).	Water	102-107	thymoma viral proto-oncogene 1	Mus musculus	0-3
19071311-6	2007	The proposed method was applied to determine As(V) in mineral water and natural water samples (river, fountain and gold mine) from Ouro Preto city.	Water	62-67	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	45-50
19071321-3	2007	Co(II) was rapidly and quantitatively back-extracted with deionised water.	Water	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
17092942-1	2007	A subset of superoxide dismutase 1 (Cu/Zn-SOD1) mutants that cause familial amyotrophic lateral sclerosis (FALS) have heightened reactivity with (-)ONOO and H(2)O(2) in vitro.	Water	157-162	superoxide dismutase 1, soluble	Mus musculus	42-46
17212500-2	2007	Water has been modeled with the extended simple point charge model (SPC/E), ions with the Tosi-Fumi model and the interaction between water and ions with the Smith-Dang model.	Water	0-5	proline rich protein gene cluster	Homo sapiens	68-71
24881713-11	2007	At a critical IAP level (around 20 cmH2O) the lymph flow starts to decrease and the splanchnic water content progressively increases.	Water	95-100	alkaline phosphatase, intestinal	Homo sapiens	14-17
17173267-0	2007	The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors.	Water	21-26	rhodopsin	Homo sapiens	74-83
17469714-11	2007	At a critical IAP level (around 20 cmH2O) the lymph flow starts to decrease and the splanchnic water content progressively increases.	Water	95-100	alkaline phosphatase, intestinal	Homo sapiens	14-17
17963321-2	2007	Infusion of TNF-alpha into the third cerebral ventricle in doses of 1 to 4 mug/rat suppressed 24-hour cumulative food and water intake dose-dependently, compared to an infusion of phosphate-buffered saline (PBS) (p &lt; 0.05 for each).	Water	122-127	tumor necrosis factor	Rattus norvegicus	12-21
17436369-2	2007	To find out whether the immunohistochemical expression of neuropeptid Y (NPY) and leptin receptor (LR) in the rat hypothalamus is influenced by adlay seed water extract (adlay), obesity in rats was induced by high fat diet (HFD) for 8 weeks; these rats were injected with 50 mg/100 g body weight adlay daily for 4 weeks.	Water	155-160	neuropeptide Y	Rattus norvegicus	58-71
17436369-2	2007	To find out whether the immunohistochemical expression of neuropeptid Y (NPY) and leptin receptor (LR) in the rat hypothalamus is influenced by adlay seed water extract (adlay), obesity in rats was induced by high fat diet (HFD) for 8 weeks; these rats were injected with 50 mg/100 g body weight adlay daily for 4 weeks.	Water	155-160	neuropeptide Y	Rattus norvegicus	73-76
16931650-6	2007	In addition, obestatin inhibited ANG II-induced water drinking in animals provided free access to water and food.	Water	48-53	angiotensinogen	Rattus norvegicus	33-39
16896188-1	2007	Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na(+) reabsorption.	Water	67-72	arginine vasopressin	Rattus norvegicus	0-11
16896188-1	2007	Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na(+) reabsorption.	Water	67-72	angiotensinogen	Rattus norvegicus	16-30
16931650-6	2007	In addition, obestatin inhibited ANG II-induced water drinking in animals provided free access to water and food.	Water	98-103	angiotensinogen	Rattus norvegicus	33-39
16896188-1	2007	Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na(+) reabsorption.	Water	67-72	angiotensinogen	Rattus norvegicus	32-38
18525108-3	2007	In the UVB-irradiated distilled water (DW)-treated group, manganese superoxide dismutase (SOD2) and glutathione peroxidase (GPx) immunoreactivity and their protein levels in the skin were significantly lower than those in the control group.	Water	32-37	superoxide dismutase 2, mitochondrial	Mus musculus	58-88
16896188-2	2007	We previously demonstrated that ANG II AT(1) receptor blockade decreases dDAVP-induced water reabsorption and AQP2 levels in rats, suggesting cross talk between these two peptide hormones (Am J Physiol Renal Physiol 288: F673-F684, 2005).	Water	87-92	angiotensinogen	Rattus norvegicus	32-38
17516711-1	2007	The antidiuretic hormone arginine-vasopressin regulates water homeostasis in the human body by binding to its vasopressin type 2 receptor (V2R).	Water	56-61	arginine vasopressin	Homo sapiens	34-45
17516711-1	2007	The antidiuretic hormone arginine-vasopressin regulates water homeostasis in the human body by binding to its vasopressin type 2 receptor (V2R).	Water	56-61	arginine vasopressin receptor 2	Homo sapiens	110-142
17174719-3	2007	METHODS: Liver cirrhosis was produced by the administration of thioacetamide (0.3 g/L of tap water) for a period of 3 months in rats.	Water	93-98	nuclear RNA export factor 1	Rattus norvegicus	89-92
16824580-12	2007	Batch adsorption-desorption studies illustrate that CP-AE could be used to remove As(V) from ground water and other industrial effluents.	Water	100-105	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	82-87
16997350-0	2007	PCB mass transfer coefficients determined by application of a water surface sampler.	Water	62-67	pyruvate carboxylase	Homo sapiens	0-3
17377937-0	2007	Investigations on the coupling of ethylene and alkynes in [IrTp Me2] compounds: water as an effective trapping agent.	Water	80-85	malic enzyme 2	Homo sapiens	64-67
17009386-1	2007	A series of six new ligands (L(1)-L(6)) suitable for the formation of luminescent lanthanide complexes in water is described.	Water	106-111	L1 cell adhesion molecule	Homo sapiens	29-33
17641406-2	2007	ET-1 also influences salt and water homeostasis through effects on the renin-angiotensin-aldosterone system and vasopressin, thus elevating blood pressure and increasing vascular tone.	Water	30-35	endothelin 1	Homo sapiens	0-4
17530724-8	2007	Several mechanistic hypotheses, including the hydrolysis of an allenol ester intermediate and SN2" addition of water, were examined to gain an insight into this transformation.	Water	111-116	solute carrier family 38 member 5	Homo sapiens	94-97
17133186-1	2007	BACKGROUND: Vasopressin is essential for cardiovascular homeostasis, acting via the kidney to regulate water resorption, on the vasculature to regulate smooth muscle tone, and as a central neurotransmitter, modulating brainstem autonomic function.	Water	103-108	arginine vasopressin	Homo sapiens	12-23
17692010-3	2007	Since the molecular identification of the first water channel, AQP1, by Peter Agre"s group, 13 homologous members have been found in mammals with varying degree of homology.	Water	48-53	aquaporin 1 (Colton blood group)	Homo sapiens	63-67
17433709-1	2007	The effect of compound nutrients on serum concentrations of the cytokines, such as interleukin (IL)-2, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in immobilization and cold water-immersion stressed rat were investigated.	Water	193-198	interleukin 6	Rattus norvegicus	147-165
18045170-5	2007	Recognizing that AQP1 is a water channel and, under permissive conditions, also a cGMP-gated cation channel, evidence in various tissues for a coupling of the cGMP signaling cascade to a physiological outcome that might involve AQP1 dual ion-and-water channel functions is of interest.	Water	27-32	aquaporin 1 (Colton blood group)	Homo sapiens	17-21
18045170-5	2007	Recognizing that AQP1 is a water channel and, under permissive conditions, also a cGMP-gated cation channel, evidence in various tissues for a coupling of the cGMP signaling cascade to a physiological outcome that might involve AQP1 dual ion-and-water channel functions is of interest.	Water	246-251	aquaporin 1 (Colton blood group)	Homo sapiens	17-21
18045170-5	2007	Recognizing that AQP1 is a water channel and, under permissive conditions, also a cGMP-gated cation channel, evidence in various tissues for a coupling of the cGMP signaling cascade to a physiological outcome that might involve AQP1 dual ion-and-water channel functions is of interest.	Water	246-251	aquaporin 1 (Colton blood group)	Homo sapiens	228-232
17433709-2	2007	Oral (gavage) administration of compound nutrients was found to attenuate the acute and chronic immobilization and cold water-immersion stress-induced increase in serum IL-6 level and decrease in IL-2 level.	Water	120-125	interleukin 6	Rattus norvegicus	169-173
26627156-0	2007	Theoretical Investigations of the Nature of Interaction of ClF with HF, H2O, and NH3.	Water	72-75	CLQTL1	Homo sapiens	59-62
17571911-2	2007	Associated with the rise in postmenopausal blood pressure (BP) are increased salt sensitivity and imbalance between the renin-angiotensin-aldosterone system and nitric oxide pathways that lead to sodium and water retention.	Water	207-212	renin	Homo sapiens	120-125
17007997-4	2007	Myeloperoxidase (MPO) is an enzyme present in the azurophile granules of neutrophils and monocytes that can contribute to LDL oxidation in the presence of H(2)O(2).	Water	155-160	myeloperoxidase	Homo sapiens	0-15
17007997-4	2007	Myeloperoxidase (MPO) is an enzyme present in the azurophile granules of neutrophils and monocytes that can contribute to LDL oxidation in the presence of H(2)O(2).	Water	155-160	myeloperoxidase	Homo sapiens	17-20
17373462-1	2007	A method was validated for the direct determination of As(III) and As(V) in water samples by ion chromatography/inductively coupled plasma-mass spectrometry.	Water	76-81	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	67-72
17210748-1	2007	The recent identification of aquaporin-8 (AQP8), an aquaporin (AQP) channel permeable to water and ammonia, in the inner membrane (IMM) of rat liver mitochondria suggested a role for such AQP in the hydration state and the metabolic function of mitochondria.	Water	89-94	aquaporin 8	Rattus norvegicus	29-40
17210748-1	2007	The recent identification of aquaporin-8 (AQP8), an aquaporin (AQP) channel permeable to water and ammonia, in the inner membrane (IMM) of rat liver mitochondria suggested a role for such AQP in the hydration state and the metabolic function of mitochondria.	Water	89-94	aquaporin 8	Rattus norvegicus	42-46
17124511-5	2007	The AFM topographs also showed that the extracellular loops of AQP0 in junctional microdomains adopt a conformation that closely resembles the structure of junctional AQP0, in which the water pore is thought to be closed.	Water	186-191	major intrinsic protein of lens fiber	Homo sapiens	63-67
17124511-5	2007	The AFM topographs also showed that the extracellular loops of AQP0 in junctional microdomains adopt a conformation that closely resembles the structure of junctional AQP0, in which the water pore is thought to be closed.	Water	186-191	major intrinsic protein of lens fiber	Homo sapiens	167-171
17299267-1	2007	The immunopharmacological profile of novel biocompatible water-soluble interleukin-2 (IL-2)-conjugated 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer immunosuppressive agents was established.	Water	57-62	interleukin 2	Homo sapiens	71-84
17299267-1	2007	The immunopharmacological profile of novel biocompatible water-soluble interleukin-2 (IL-2)-conjugated 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer immunosuppressive agents was established.	Water	57-62	interleukin 2	Homo sapiens	86-90
17079242-12	2007	Survival 48 h after treatment with 2 x 30 microg (3 mg/kg) of AcpP peptide-PMO or 2 x 3 mg (300 mg/kg) of AcpP PMO was 100%, compared with 20% for mice treated with water or scrambled base sequence PMO controls.	Water	165-170	acid phosphatase, prostate	Mus musculus	62-66
17135396-0	2007	Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.	Water	127-132	arginine vasopressin	Homo sapiens	106-117
17135396-1	2007	The cAMP/protein kinase A (PKA)-dependent insertion of water channel aquaporin-2 (AQP2)-bearing vesicles into the plasma membrane in renal collecting duct principal cells (AQP2 shuttle) constitutes the molecular basis of arginine vasopressin (AVP)-regulated water reabsorption.	Water	55-60	arginine vasopressin	Homo sapiens	230-241
17135396-5	2007	The selective PDE4 inhibitor rolipram increases AKAP-tethered PKA activity on AQP2-bearing vesicles and enhances the AQP2 shuttle and thereby the osmotic water permeability.	Water	154-159	phosphodiesterase 4A	Homo sapiens	14-18
19169381-3	2007	Hydrogen bonds between water molecules in simulations are treated most frequently by using point charge water potentials, such as TIP3P or SPC, sometimes with a polarizable extension.	Water	23-28	proline rich protein gene cluster	Homo sapiens	139-142
26627156-1	2007	The interactions of the first-row hydrides (HF, H2O, and NH3) with ClF have been investigated by performing calculations at the second-order perturbation theory based on the Moller-Plesset partition of the Hamiltonian with the aug-cc-pVTZ basis set.	Water	48-51	CLQTL1	Homo sapiens	67-70
17356196-1	2007	Hyponatremia, defined as a serum sodium concentration ([Na+]) less than 135 mEq/L, is commonly caused by elevated levels of the hormone arginine vasopressin (AVP), which causes water retention.	Water	177-182	arginine vasopressin	Homo sapiens	145-156
17222168-1	2007	The discovery of aquaporin-1 (AQP1) explained the long-standing biophysical question of how water specifically crosses biological membranes.	Water	92-97	aquaporin 1 (Colton blood group)	Homo sapiens	17-28
17222168-1	2007	The discovery of aquaporin-1 (AQP1) explained the long-standing biophysical question of how water specifically crosses biological membranes.	Water	92-97	aquaporin 1 (Colton blood group)	Homo sapiens	30-34
16972066-0	2007	Conformational stability and three-dimensional model of the delta-opioid pharmacophore for the extended antiparallel dimer structure of Met-enkephalin in water.	Water	154-159	proopiomelanocortin	Homo sapiens	136-150
16972066-1	2007	The conformational stability of the extended antiparallel dimer structure of Met-enkephalin in water was analyzed by examining the hydration structure of enkephalin using molecular dynamics simulations.	Water	95-100	proopiomelanocortin	Homo sapiens	77-91
17446714-8	2007	Wild-type and Spam1 null mice given free access to water showed significantly reduced urine volumes (p &lt; 0.01; n = 12) in the latter.	Water	51-56	sperm adhesion molecule 1	Mus musculus	14-19
17999203-4	2007	Administration of orexin in rats has been shown to induce increased water intake with a longer-lasting effect than angiotensin II, which is also known as a potent dipsogen.	Water	68-73	hypocretin neuropeptide precursor	Rattus norvegicus	18-24
17209132-2	2007	Catalase is a major antioxidant enzyme that detoxifies hydrogen peroxide by converting it into water and oxygen, thereby preventing cellular injury by oxidative stress.	Water	95-100	catalase	Homo sapiens	0-8
17898480-9	2007	Thus it was concluded that combinational administration of the A. blazei Murill water extract and the marine phospholipid may be useful in myeloma sp2 therapy.	Water	80-85	Sp2 transcription factor	Mus musculus	147-150
17141371-0	2007	Recombinant production and structural studies of the Aplysia water-borne protein pheromone enticin indicates it has a novel disulfide stabilized fold.	Water	61-66	enticin	Aplysia californica	91-98
18029717-6	2007	In DPV measurement, the concentration of RNaseA was linear in the range of 10(-10) - 10(-8) M and the amount of RNase in the tap water could be estimated.	Water	129-134	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	125-128
17305120-2	2007	A commercial catalase, which is an enzyme to decompose hydrogen peroxide to water and oxygen, was entrapped in chitosan beads.	Water	76-81	catalase	Homo sapiens	13-21
17510888-5	2007	Negligible permeability was observed for NAG in neat solutions of known membrane permeation enhancers ethanol, oleic acid, isopropyl myristate, and isopropyl palmitate, as well as from saturated solutions of NAG in water or phosphate buffer.	Water	215-220	N-acetyl-alpha-glucosaminidase	Homo sapiens	208-211
17935120-0	2007	Oxygen exchange between (de)nitrification intermediates and H2O and its implications for source determination of NO3- and N2O: a review.	Water	60-63	NBL1, DAN family BMP antagonist	Homo sapiens	113-116
17106869-0	2007	The water extract of Omija protects H9c2 cardiomyoblast cells from hydrogen peroxide through prevention of mitochondrial dysfunction and activation of caspases pathway.	Water	4-9	caspase 9	Rattus norvegicus	151-159
17106869-8	2007	Taken together, these data indicate that the water extract of Omija protects H9c2 cardiomyoblast cells from oxidative stress of H(2)O(2) through inhibition of mitochondrial dysfunction and activation of intrinsic caspase cascades, including caspase-3 and caspase-9.	Water	45-50	caspase 9	Rattus norvegicus	213-220
17106869-8	2007	Taken together, these data indicate that the water extract of Omija protects H9c2 cardiomyoblast cells from oxidative stress of H(2)O(2) through inhibition of mitochondrial dysfunction and activation of intrinsic caspase cascades, including caspase-3 and caspase-9.	Water	45-50	caspase 9	Rattus norvegicus	255-264
17113801-3	2007	The most commonly used tussive agents include capsaicin, citric acid and ultrasonically nebulized distilled water (fog).	Water	108-113	zinc finger protein, FOG family member 1	Homo sapiens	115-118
17879040-0	2007	Water-clear cell parathyroid adenoma causing primary hyperparathyroidism in a patient with neurofibromatosis type 1: report of a case.	Water	0-5	neurofibromin 1	Homo sapiens	91-115
17879040-10	2007	This is the first reported case of water-clear cell parathyroid adenoma associated with NF1.	Water	35-40	neurofibromin 1	Homo sapiens	88-91
18350711-6	2007	RESULTS: The increase in mucins concentration in distilled water and in NaCl and KCl solutions causes a drop of pH: 7.0--&gt;5.4; 7.5--&gt;5.0 and 7.2--&gt;5.4 respectively but in mucin-HGl solution pH value was constant.	Water	59-64	lipase F, gastric type	Homo sapiens	186-189
17113926-11	2006	The increase in the catalase activity (500 UEA/1 microL/rat injected into the 4th V) also abolished both, pressor and bradycardic responses to H(2)O(2).	Water	143-148	catalase	Rattus norvegicus	20-28
18030731-7	2007	New data have been presented which indicate that the changes in the lattice of water molecules and allosteric nucleus of Na(+)-binding site of the enzyme are the basic link of raising the affinity between the thrombin and substrate and mechanism of the enzyme activation by Na(+)-ions.	Water	79-84	coagulation factor II, thrombin	Homo sapiens	209-217
17654319-5	2007	Urinary osmolality and plasmatic vasopressin concentration were significantly reduced after an assumption of both kinds of water.	Water	123-128	arginine vasopressin	Homo sapiens	33-44
17654319-6	2007	However, serum vasopressin was lower after HM water assumption than after LM.	Water	46-51	arginine vasopressin	Homo sapiens	15-26
17442163-7	2007	The level of EPO mRNA in the hfRPE cells reached a peak when exposed to 600 micromol/L H(2)O(2), then decreased after exposing to 800 micromol/L H(2)O(2).	Water	87-93	erythropoietin	Homo sapiens	13-16
17442163-7	2007	The level of EPO mRNA in the hfRPE cells reached a peak when exposed to 600 micromol/L H(2)O(2), then decreased after exposing to 800 micromol/L H(2)O(2).	Water	87-92	erythropoietin	Homo sapiens	13-16
17179045-2	2006	In the case of interleukin-1beta (IL-1beta), four independent structures solved by x-ray crystallography indicate that water is not present in the central apolar cavity.	Water	119-124	interleukin 1 beta	Homo sapiens	15-32
17179045-2	2006	In the case of interleukin-1beta (IL-1beta), four independent structures solved by x-ray crystallography indicate that water is not present in the central apolar cavity.	Water	119-124	interleukin 1 beta	Homo sapiens	34-42
17165784-0	2006	Photosensitized reduction of water to hydrogen using human serum albumin complexed with zinc-protoporphyrin IX.	Water	29-34	albumin	Homo sapiens	59-72
17165784-1	2006	We present the photophysical properties of complexes of recombinant human serum albumin (rHSA) with Zn(II)-protoporphyrin IX (ZnPP) and their activities in the photosensitized reduction of water to hydrogen (H2) using methyl viologen (MV2+) as an electron relay.	Water	189-194	albumin	Homo sapiens	74-87
17117223-6	2006	In addition to the added electrocatalysis a significant percentage of O2 reduced at the oxidized Co(II)/Pt(II) EPG electrode is converted to H2O as determined by rotating disk electrode measurements.	Water	141-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
17140248-0	2006	Relevance of the ligand exchange rate and mechanism of fac-[(CO)3M(H2O)3]+ (M = Mn, Tc, Re) complexes for new radiopharmaceuticals.	Water	67-70	FA complementation group C	Homo sapiens	55-58
17140248-1	2006	The water exchange process on fac-[(CO)3Mn(H2O)3]+ and fac-[(CO)3Tc(H2O)3]+ was kinetically investigated by 17O NMR as a function of the acidity, temperature, and pressure.	Water	43-46	FA complementation group C	Homo sapiens	30-33
17147356-2	2006	The water-soluble QDs are synthesized with the thrombin-binding aptamer, which retains the secondary quadruplex structure necessary for binding to thrombin.	Water	4-9	coagulation factor II, thrombin	Homo sapiens	47-55
17147356-2	2006	The water-soluble QDs are synthesized with the thrombin-binding aptamer, which retains the secondary quadruplex structure necessary for binding to thrombin.	Water	4-9	coagulation factor II, thrombin	Homo sapiens	147-155
17140248-1	2006	The water exchange process on fac-[(CO)3Mn(H2O)3]+ and fac-[(CO)3Tc(H2O)3]+ was kinetically investigated by 17O NMR as a function of the acidity, temperature, and pressure.	Water	68-71	FA complementation group C	Homo sapiens	55-58
17140248-1	2006	The water exchange process on fac-[(CO)3Mn(H2O)3]+ and fac-[(CO)3Tc(H2O)3]+ was kinetically investigated by 17O NMR as a function of the acidity, temperature, and pressure.	Water	4-9	FA complementation group C	Homo sapiens	30-33
17140248-2	2006	Up to pH 6.3 and 4.4, respectively, the exchange rate is not affected by the acidity, thus demonstrating that the contribution of the monohydroxo species fac-[(CO)3M(OH)(H2O)2] is not significant, which correlates well with a higher pKa for these complexes compared to the homologue fac-[(CO)3Re(H2O)3]+ complex.	Water	170-173	FA complementation group C	Homo sapiens	154-157
17140248-6	2006	The substitution of water in fac-[(CO)3M(H2O)3]+ by dimethyl sulfide (DMS) is slightly faster than that by CH3CN: 3 times faster for Mn, 1.5 times faster for Tc, and 1.2 times faster for Re.	Water	20-25	FA complementation group C	Homo sapiens	29-32
16802304-1	2006	The gelation process of lysozyme in water/tetramethylurea in the presence of salt was investigated as a function of temperature and system composition by rheology, infrared spectroscopy, and microcalorimetry.	Water	36-41	lysozyme	Homo sapiens	24-32
17140248-1	2006	The water exchange process on fac-[(CO)3Mn(H2O)3]+ and fac-[(CO)3Tc(H2O)3]+ was kinetically investigated by 17O NMR as a function of the acidity, temperature, and pressure.	Water	4-9	FA complementation group C	Homo sapiens	55-58
17030801-0	2006	Dual function of an Arabidopsis transcription factor DREB2A in water-stress-responsive and heat-stress-responsive gene expression.	Water	63-68	DRE-binding protein 2A	Arabidopsis thaliana	53-59
16875643-2	2006	Because water immersion produces a marked central redistribution of blood volume and suppresses the renin-angiotensin system response and sympathetic activity, we hypothesized that water immersion might be useful in the treatment of preeclampsia.	Water	8-13	renin	Homo sapiens	100-105
16875643-2	2006	Because water immersion produces a marked central redistribution of blood volume and suppresses the renin-angiotensin system response and sympathetic activity, we hypothesized that water immersion might be useful in the treatment of preeclampsia.	Water	181-186	renin	Homo sapiens	100-105
17046708-4	2006	Based on its IR spectra, the synthesized alpha-CTD phase was stable in water.	Water	71-76	CTD	Homo sapiens	47-50
17134154-6	2006	For a solvent of 50:50 methanol/water (v/v), lowering the flow from 200 to 50 microL min-1 results in a 10x increase in charge exchange ionization efficiency--further flow reductions provide even greater enhancements.	Water	32-37	CD59 molecule (CD59 blood group)	Homo sapiens	85-90
16978863-3	2006	Enzyme potency against Chek1 was optimized by the incorporation of a hydroxymethyl triazole moiety in compound 21 (Chek1 IC(50)=0.30nM) that was shown by X-ray crystallography to displace one of three highly conserved water molecules in the HI region of the ATP-binding cleft.	Water	218-223	checkpoint kinase 1	Homo sapiens	23-28
16978863-3	2006	Enzyme potency against Chek1 was optimized by the incorporation of a hydroxymethyl triazole moiety in compound 21 (Chek1 IC(50)=0.30nM) that was shown by X-ray crystallography to displace one of three highly conserved water molecules in the HI region of the ATP-binding cleft.	Water	218-223	checkpoint kinase 1	Homo sapiens	115-120
17030801-9	2006	Collectively, these results indicate that DREB2A functions in both water and HS-stress responses.	Water	67-72	DRE-binding protein 2A	Arabidopsis thaliana	42-48
17348203-1	2006	In the present study, we measured the antibody-catalyzed 03 formation from THP-1 monocytes activated by phorbol myristate acetate (PMA) by indigo carmine bleaching reaction test, and the accumulation of cholesterol in THP-1 monocytes by fluorescence spectrophotometric method, and analyzed the cholesterol ozonation product 5,6-secosterol by high-performance liquid chromatography (HPLC), to explore the potential effect of antibody-catalyzed water oxidation on pathogenesis of atherosclerosis.	Water	443-448	GLI family zinc finger 2	Homo sapiens	75-80
17205897-4	2006	Within the uncertainties of the two techniques, there is good agreement between the MIMS and IRMS results, which indicates that the production of N2 by the coupled process of nitrification/denitrification was relatively unimportant and surface-water NO3- was the dominant source of NO3- for benthic denitrification in these streams.	Water	244-249	NBL1, DAN family BMP antagonist	Homo sapiens	250-253
17348203-4	2006	These results demonstrated that the activated THP-1 monocytes possess the ability to produce O3 through antibody-catalyzed water-oxidation pathway, which could be a new mechanism concerned with atheriosclerosis.	Water	123-128	GLI family zinc finger 2	Homo sapiens	46-51
16601981-17	2006	It is presumed that the ICOS/B7RP-1 costimulatory pathway may play a role in the development of EAU.	Water	96-99	inducible T-cell co-stimulator	Rattus norvegicus	24-28
17089010-0	2006	Comano"s (Trentino) thermal water interferes with interleukin-6 production and secretion and with cytokeratin-16 expression by cultured human psoriatic keratinocytes: further potential mechanisms of its anti-psoriatic action.	Water	28-33	interleukin 6	Homo sapiens	50-63
17070001-1	2006	Vasopressin regulates water excretion from the kidney by increasing water permeability of the collecting duct as a hormone secreted from the posterior pituitary.	Water	22-27	arginine vasopressin	Rattus norvegicus	0-11
17070001-1	2006	Vasopressin regulates water excretion from the kidney by increasing water permeability of the collecting duct as a hormone secreted from the posterior pituitary.	Water	68-73	arginine vasopressin	Rattus norvegicus	0-11
17146318-9	2006	CONCLUSION: The results of this study demonstrate that water ingestion can limit exercise-induced increases in serum S100beta, consistent with the preservation of BBB integrity.	Water	55-60	S100 calcium binding protein B	Homo sapiens	117-125
17076765-3	2006	Increased vasopressin release in turn induces water resorption through the kidneys.	Water	46-51	arginine vasopressin	Homo sapiens	10-21
17010357-5	2006	Transmission electron microscopy (TEM) measurements and time-dependent phase monitoring indicated that the colloidal stability of modified HAp over unmodified HAp in water dramatically increased and tended to exist as single nanocrystals without aggregation.	Water	166-171	retinoic acid receptor beta	Homo sapiens	139-142
17010357-5	2006	Transmission electron microscopy (TEM) measurements and time-dependent phase monitoring indicated that the colloidal stability of modified HAp over unmodified HAp in water dramatically increased and tended to exist as single nanocrystals without aggregation.	Water	166-171	retinoic acid receptor beta	Homo sapiens	159-162
16830357-7	2006	Through MS2 and MS3 studies of a synthetic peptide standard AGHKLL and its chemically labeled and isotope-encoded forms, we discovered that the water loss from the b(3) ion involves the carbonyl group of His, the hydrogen connected to the alpha-carbon of Gly, and the amide hydrogen of His.	Water	144-149	MS3	Homo sapiens	16-19
17112281-3	2006	The eight-coordinate, water-soluble Cd(II) complexes of (L1)4+ and (L2)4-, [CdL1](CF3SO3)6 and (NH4)2-[CdL2], the former cationic and the latter anionic, have both been shown to be capable of acting as anion receptors in aqueous solution.	Water	22-27	Cornelia de Lange syndrome 2	Homo sapiens	103-107
16973240-4	2006	The effect of leptin on ERK and Na(+), K(+)-ATPase was abolished by catalase, specific inhibitors of epidermal growth factor (EGF) receptor, AG1478 and PD158780, as well as by ERK inhibitor, PD98059, and was mimicked by both exogenous H(2)O(2) and EGF.	Water	235-240	Eph receptor B1	Rattus norvegicus	24-27
17261971-1	2006	Water homeostasis in the body is finely balanced by the release of the antidiuretic hormone vasopressin and the stimulation of thirst.	Water	0-5	arginine vasopressin	Homo sapiens	92-103
17326999-9	2006	The longer the illness lasted, the higher the frequency of defecation and the larger the amount of water was found in stool, the lower the level of AQP8 mRNA expression in colonic mucosa.	Water	99-104	aquaporin 8	Homo sapiens	148-152
17125398-0	2006	Collective dynamics of lysozyme in water: terahertz absorption spectroscopy and comparison with theory.	Water	35-40	lysozyme	Homo sapiens	23-31
17027169-2	2006	Since central administrations of galanin (GAL) suppress water intake and vasopressin release, GAL may inhibit the neural activity of SFO neurons.	Water	56-61	galanin and GMAP prepropeptide	Rattus norvegicus	33-40
17027169-2	2006	Since central administrations of galanin (GAL) suppress water intake and vasopressin release, GAL may inhibit the neural activity of SFO neurons.	Water	56-61	galanin and GMAP prepropeptide	Rattus norvegicus	42-45
17027169-11	2006	The response to GAL is inhibitory, mediated at least in part by GalR1 and provides a plausible explanation for the opposite effects of ANGII and GAL seen in vivo on water intake and vasopressin release.	Water	165-170	galanin and GMAP prepropeptide	Rattus norvegicus	16-19
17027169-11	2006	The response to GAL is inhibitory, mediated at least in part by GalR1 and provides a plausible explanation for the opposite effects of ANGII and GAL seen in vivo on water intake and vasopressin release.	Water	165-170	angiotensinogen	Rattus norvegicus	135-140
17027169-11	2006	The response to GAL is inhibitory, mediated at least in part by GalR1 and provides a plausible explanation for the opposite effects of ANGII and GAL seen in vivo on water intake and vasopressin release.	Water	165-170	galanin and GMAP prepropeptide	Rattus norvegicus	145-148
17006975-9	2006	Treatment of rats with water extracts or ethanol extracts of DG, CX and DH at daily dosages equivalent to 3 g (dry herbal material)/kg all increased the microsome protein contents and decreased the total CYP levels.	Water	23-28	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	204-207
17006975-11	2006	The other water extracts all showed inhibition against CYP isoforms.	Water	10-15	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	55-58
17125309-1	2006	The structural and dynamical properties of NO3- in dilute aqueous solution have been investigated by means of two combined quantum mechanics/molecular mechanics (QM/MM) molecular dynamics simulations, namely HF/MM and B3LYP/MM, in which the ion and its surrounding water molecules were treated at HF and B3LYP levels of accuracy, respectively, using the DZV+ basis set.	Water	265-270	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
17125309-2	2006	On the basis of both HF and B3LYP methods, a well-defined first hydration shell of NO3- is obtainable, but the shell is quite flexible and the hydrogen-bond interactions between NO3- and water are rather weak.	Water	187-192	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
17125309-2	2006	On the basis of both HF and B3LYP methods, a well-defined first hydration shell of NO3- is obtainable, but the shell is quite flexible and the hydrogen-bond interactions between NO3- and water are rather weak.	Water	187-192	NBL1, DAN family BMP antagonist	Homo sapiens	178-181
17125309-4	2006	In addition, the dynamical information, i.e., the bond distortions and shifts in the corresponding bending and stretching frequencies as well as the mean residence time of water molecules surrounding the NO3- ion, clearly indicates the "structure-breaking" ability of this ion in aqueous solution.	Water	172-177	NBL1, DAN family BMP antagonist	Homo sapiens	204-207
17723778-5	2006	The proposed procedure was applied for Ni(II) and Co(II) determination in water certified reference materials.	Water	74-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
16871401-3	2006	The present study examines, by gel electrophoresis and Western blotting, the expression levels of the water channels aquaporin 1 (AQP1) and aquaporin 4 (AQP4) in the frontal cortex (area 8) homogenates of sporadic CJD cases (six men, four women; seven cases with methionine/methionine at codon 129 and PrP type 1; two cases with valine/valine at codon 129 and PrP type 2, and one case methionine/valine at codon 129 and PrP type 1) compared with age-matched controls, and cases with Alzheimer"s disease (AD, stage VI of Braak and Braak) and diffuse Lewy body disease (DLB).	Water	102-107	aquaporin 1 (Colton blood group)	Homo sapiens	117-128
17153996-2	2006	The higher content of NO3- in groundwater compared to surface water during both summer and winter seasons indicates that the karstic groundwater system cannot easily recover once contaminated with nitrate.	Water	36-41	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
17723766-5	2006	The chemosensor has been used for determination of Co(II) in water samples.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
17115765-1	2006	The path-integral molecular dynamics and centroid molecular dynamics methods have been applied to investigate the behavior of liquid water at ambient conditions starting from a recently developed simple point charge/flexible (SPC/Fw) model.	Water	133-138	proline rich protein gene cluster	Homo sapiens	226-229
17115765-7	2006	A modification of the original parametrization of the SPC/Fw model is suggested and tested in order to construct an accurate quantum model, called q-SPC/Fw, for liquid water.	Water	168-173	proline rich protein gene cluster	Homo sapiens	54-57
17115765-7	2006	A modification of the original parametrization of the SPC/Fw model is suggested and tested in order to construct an accurate quantum model, called q-SPC/Fw, for liquid water.	Water	168-173	proline rich protein gene cluster	Homo sapiens	149-152
17115765-9	2006	Finally, a force-matching approach was applied to the q-SPC/Fw model to derive an effective quantum force field for liquid water in which the effects due to the nuclear quantization are explicitly distinguished from those due to the underlying molecular interactions.	Water	123-128	proline rich protein gene cluster	Homo sapiens	56-59
16871401-3	2006	The present study examines, by gel electrophoresis and Western blotting, the expression levels of the water channels aquaporin 1 (AQP1) and aquaporin 4 (AQP4) in the frontal cortex (area 8) homogenates of sporadic CJD cases (six men, four women; seven cases with methionine/methionine at codon 129 and PrP type 1; two cases with valine/valine at codon 129 and PrP type 2, and one case methionine/valine at codon 129 and PrP type 1) compared with age-matched controls, and cases with Alzheimer"s disease (AD, stage VI of Braak and Braak) and diffuse Lewy body disease (DLB).	Water	102-107	aquaporin 1 (Colton blood group)	Homo sapiens	130-134
16871401-3	2006	The present study examines, by gel electrophoresis and Western blotting, the expression levels of the water channels aquaporin 1 (AQP1) and aquaporin 4 (AQP4) in the frontal cortex (area 8) homogenates of sporadic CJD cases (six men, four women; seven cases with methionine/methionine at codon 129 and PrP type 1; two cases with valine/valine at codon 129 and PrP type 2, and one case methionine/valine at codon 129 and PrP type 1) compared with age-matched controls, and cases with Alzheimer"s disease (AD, stage VI of Braak and Braak) and diffuse Lewy body disease (DLB).	Water	102-107	complement component 4 binding protein alpha	Homo sapiens	302-305
16788141-1	2006	The kidney responds to high levels of ANG II, as may occur during malignant hypertension, by increasing sodium and water excretion.	Water	115-120	angiotensinogen	Rattus norvegicus	38-44
17132443-3	2006	Paste standardization appeared to be the main obstacle to in situ application of this approach, and the present study shows how FT-IR/ATR can be used to estimate both water content and nitrate concentration of field soil samples.	Water	167-172	ATR serine/threonine kinase	Homo sapiens	128-137
17099278-3	2006	The average PCB recovery of the final procedure, at a concentration of 18 ng/L in reagent water, was 101% with relative standard deviations ranging from 1 to 5% for the different congeners.	Water	90-95	pyruvate carboxylase	Homo sapiens	12-15
17132443-5	2006	An a priori determined amount of highly concentrated nitrate solution is added to the first subsample and the ATR spectrum of this paste is used to estimate the sample water content.	Water	168-173	ATR serine/threonine kinase	Homo sapiens	110-113
17054670-3	2006	This study demonstrated that adding the water-soluble vitamin nicotinamide (NIC) to mobilised peripheral blood CD34+ cells cultured with thrombopoietin (Tpo) more than doubled the percentage of high-ploidy (&gt; or = 8N) MK cells.	Water	40-45	CD34 molecule	Homo sapiens	111-115
17056473-4	2006	Immunoassays were used to determine the plasma levels of TGF-alpha and epidermal growth factor receptor (EGFR), which is the receptor for TGF-alpha, in residents of an arseniasis area of Taiwan in relation to their estimated cumulative arsenic exposure from drinking water.	Water	267-272	epidermal growth factor receptor	Homo sapiens	71-103
16905183-3	2006	Western blot analysis showed that the recombinant protein, r(FL/bFGF), was solubilized with CaCl(2)/ethanol/water, but not with trypsin, indicating that r(FL/bFGF) was in fibroin layers.	Water	108-113	fibroblast growth factor 2	Homo sapiens	64-68
16905184-7	2006	This is explained by repulsion among fibrinogens, affecting water structure and thus the strength of fibrinogen interactions on the surface.	Water	60-65	fibrinogen beta chain	Homo sapiens	37-47
17054670-3	2006	This study demonstrated that adding the water-soluble vitamin nicotinamide (NIC) to mobilised peripheral blood CD34+ cells cultured with thrombopoietin (Tpo) more than doubled the percentage of high-ploidy (&gt; or = 8N) MK cells.	Water	40-45	thrombopoietin	Homo sapiens	137-151
17054670-3	2006	This study demonstrated that adding the water-soluble vitamin nicotinamide (NIC) to mobilised peripheral blood CD34+ cells cultured with thrombopoietin (Tpo) more than doubled the percentage of high-ploidy (&gt; or = 8N) MK cells.	Water	40-45	thrombopoietin	Homo sapiens	153-156
17045502-2	2006	Cytosolic-enzyme catalase (CAT) is a component of the antioxidant defence system that reduces hydrogen peroxide (H(2)O(2)) to water (H(2)O).	Water	113-118	catalase	Mus musculus	17-25
16544145-8	2006	CONCLUSIONS: M4N and maltose-tri-O-methyl nordihydroguaiaretic acid (maltose-M3N), a water-soluble derivative of NDGA, were also able to reverse the MDR phenotype of the tumor cells in a xenograft model system and combination therapy with M4N or maltose-M3N and paclitaxel was effective at inhibiting growth of these tumors in nude mice.	Water	85-90	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	149-152
16923776-5	2006	Surprisingly, TRPV1 knockout mice not only detected NaCl in the presence of amiloride but they preferred NaCl over water at concentrations avoided by the wild-type mice.	Water	115-120	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-19
17045502-2	2006	Cytosolic-enzyme catalase (CAT) is a component of the antioxidant defence system that reduces hydrogen peroxide (H(2)O(2)) to water (H(2)O).	Water	113-118	catalase	Mus musculus	27-30
17045502-2	2006	Cytosolic-enzyme catalase (CAT) is a component of the antioxidant defence system that reduces hydrogen peroxide (H(2)O(2)) to water (H(2)O).	Water	126-131	catalase	Mus musculus	17-25
17045502-2	2006	Cytosolic-enzyme catalase (CAT) is a component of the antioxidant defence system that reduces hydrogen peroxide (H(2)O(2)) to water (H(2)O).	Water	126-131	catalase	Mus musculus	27-30
17203778-2	2006	Loading with water pressure (up to 5 g) alone did not affect the cell proliferation, but significantly enhanced the cytotoxic activity of millimolar concentrations of NaF.	Water	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	167-170
17056569-5	2006	Phosphorylation of PKCalpha(Thr638), an autophosphorylation site indicating enzyme activity, was increased by Ab cross-linking of VCAM-1 on endothelial cells or by the exogenous addition of 1 muM H(2)O(2).	Water	196-201	protein kinase C alpha	Homo sapiens	19-27
17056569-5	2006	Phosphorylation of PKCalpha(Thr638), an autophosphorylation site indicating enzyme activity, was increased by Ab cross-linking of VCAM-1 on endothelial cells or by the exogenous addition of 1 muM H(2)O(2).	Water	196-201	vascular cell adhesion molecule 1	Homo sapiens	130-136
17056569-6	2006	The anti-VCAM-1-stimulated phosphorylation of PKCalpha(Thr638) was blocked by scavenging of H(2)O(2) and by inhibition of NADPH oxidase.	Water	92-97	vascular cell adhesion molecule 1	Homo sapiens	9-15
17056569-6	2006	The anti-VCAM-1-stimulated phosphorylation of PKCalpha(Thr638) was blocked by scavenging of H(2)O(2) and by inhibition of NADPH oxidase.	Water	92-97	protein kinase C alpha	Homo sapiens	46-54
16954445-10	2006	This is the first study to show that ANXA4 transcription and translation are regulated by progesterone and suggests that ANXA4 may be important in regulating ion and water transport across the endometrial epithelium.	Water	166-171	annexin A4	Homo sapiens	37-42
16954445-10	2006	This is the first study to show that ANXA4 transcription and translation are regulated by progesterone and suggests that ANXA4 may be important in regulating ion and water transport across the endometrial epithelium.	Water	166-171	annexin A4	Homo sapiens	121-126
17203778-4	2006	However, the enhancement of cytotoxicity of NaF under water pressure was observed even in the Ca2+ -free medium.	Water	54-59	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
17385429-0	2006	[Role of Ca2+ and aquaporin-2 in regulation of basolateral water permeability of collecting ducts in the rat kidney].	Water	59-64	carbonic anhydrase 2	Rattus norvegicus	9-12
17081961-7	2006	In these cases, mutations have been identified in the aquaporin-2 gene (AQP2), which is located in chromosome region 12q13 and codes for the vasopressin-sensitive water channel.	Water	163-168	arginine vasopressin	Homo sapiens	141-152
16480766-3	2006	In the present study, we detected a significant uptake of water, urea and mannitol sensitive to mercury and phloretin in explants from normal term placenta, which indicates a functional AQP9.	Water	58-63	aquaporin 9	Homo sapiens	186-190
16917908-4	2006	Specifically, the dimanganese form of DF1 is a mimic of the natural enzyme manganese catalase, which catalyzes the dismutation reaction of hydrogen peroxide into water and oxygen.	Water	162-167	catalase	Homo sapiens	85-93
17385429-1	2006	The role of AQP2,3 and intracellular calcium in vasopressin-induced increase in the water permeability of the basolateral cell membrane in microdissected rat kidney OMCD was studied.	Water	84-89	arginine vasopressin	Rattus norvegicus	48-59
17385429-3	2006	Preliminary loading of cells with BAPTA-AM which binds intracellular Ca2+ abolished the increase in the water permeability and prevented the rise of the AQP2 content in response to dDAVP.	Water	104-109	carbonic anhydrase 2	Rattus norvegicus	69-72
17042615-1	2006	The dynamical properties of the soft sticky dipole-quadrupole-octupole (SSDQO) water model using SPC/E moments are calculated utilizing molecular dynamics simulations.	Water	79-84	proline rich protein gene cluster	Homo sapiens	97-100
17543213-1	2006	A critical analysis of the discovery of the first water channel protein (later called aquaporin 1) has been performed.	Water	50-55	aquaporin 1 (Colton blood group)	Homo sapiens	86-97
17543216-9	2006	We have thus a world priority in the discovery of the first water channel in the RBC membrane, that was re-discovered by chance by the group of Agre (Baltimore, USA) in 1988, when they isolated a new protein from the RBC membrane, nick-named CHIP28 (channel-forming integral membrane protein of 28 kDa).	Water	60-65	aquaporin 1 (Colton blood group)	Homo sapiens	242-248
17543216-9	2006	We have thus a world priority in the discovery of the first water channel in the RBC membrane, that was re-discovered by chance by the group of Agre (Baltimore, USA) in 1988, when they isolated a new protein from the RBC membrane, nick-named CHIP28 (channel-forming integral membrane protein of 28 kDa).	Water	60-65	aquaporin 1 (Colton blood group)	Homo sapiens	250-301
17543216-11	2006	Only in 1992 the Agre"s group suggested that "it is likely that CHIP28 is a functional unit of membrane water channels".	Water	104-109	aquaporin 1 (Colton blood group)	Homo sapiens	64-70
17723752-4	2006	In an indicative application, Pb(II) ion levels were determined in tap water using bismuth-plated carbon microdisc electrodes.	Water	71-76	submaxillary gland androgen regulated protein 3B	Homo sapiens	30-36
17066031-4	2006	To examine this hypothesis, here we report the effect of water on electrical conductivity and its anisotropy for hydrogen-doped and undoped olivine at 500-1,500 K and 3 GPa.	Water	57-62	glycophorin A (MNS blood group)	Homo sapiens	169-172
17034250-0	2006	Dielectric studies of water clusters in cyclodextrins: Relevance to the transition between slow and fast forms of thrombin.	Water	22-27	coagulation factor II, thrombin	Homo sapiens	114-122
17034250-6	2006	The case of thrombin, an allosteric enzyme incorporating a network of 20 internal hydrogen bonded water molecules, is discussed.	Water	98-103	coagulation factor II, thrombin	Homo sapiens	12-20
16945327-8	2006	When compared with littermate wild-type mice (HNF4-gamma(+/+)), the HNF4-gamma knockout (HNF4-gamma(-/-)) mice had lowered energy expenditure and locomotor activity during night time that resulted in a higher body weight despite having reduced intake of food and water.	Water	263-268	hepatocyte nuclear factor 4, gamma	Mus musculus	68-78
16945327-8	2006	When compared with littermate wild-type mice (HNF4-gamma(+/+)), the HNF4-gamma knockout (HNF4-gamma(-/-)) mice had lowered energy expenditure and locomotor activity during night time that resulted in a higher body weight despite having reduced intake of food and water.	Water	263-268	hepatocyte nuclear factor 4, gamma	Mus musculus	68-78
17031957-2	2006	The new probe is highly water soluble with a large stability constant of approximately 10(21) and a wide pH available range (pH 3-10), and can specifically react with (1)O2 to form its endoperoxide (EP-MTTA-Eu(3+)) with a high reaction rate constant at 10(10) M(-1) s(-1), accompanied by the remarkable increases of luminescence quantum yield from 0.90% to 13.8% and lifetime from 0.80 to 1.29 ms, respectively.	Water	24-29	mitochondrially encoded tRNA alanine	Homo sapiens	202-206
17015180-3	2006	The current paradigm is that the presence of SOD results in a lower level of H(2)O(2) because it would prevent the non-enzymatic reactions of superoxide that form H(2)O(2).	Water	77-82	superoxide dismutase 1	Homo sapiens	45-48
17015180-3	2006	The current paradigm is that the presence of SOD results in a lower level of H(2)O(2) because it would prevent the non-enzymatic reactions of superoxide that form H(2)O(2).	Water	163-168	superoxide dismutase 1	Homo sapiens	45-48
17015180-4	2006	The goal of this work was to: a) demonstrate that SOD can increase the flux of H(2)O(2), and b) use kinetic modelling to determine what kinetic and thermodynamic conditions result in SOD increasing the flux of H(2)O(2).	Water	79-84	superoxide dismutase 1	Homo sapiens	50-53
17015180-4	2006	The goal of this work was to: a) demonstrate that SOD can increase the flux of H(2)O(2), and b) use kinetic modelling to determine what kinetic and thermodynamic conditions result in SOD increasing the flux of H(2)O(2).	Water	79-84	superoxide dismutase 1	Homo sapiens	183-186
17015180-4	2006	The goal of this work was to: a) demonstrate that SOD can increase the flux of H(2)O(2), and b) use kinetic modelling to determine what kinetic and thermodynamic conditions result in SOD increasing the flux of H(2)O(2).	Water	210-215	superoxide dismutase 1	Homo sapiens	50-53
17015180-4	2006	The goal of this work was to: a) demonstrate that SOD can increase the flux of H(2)O(2), and b) use kinetic modelling to determine what kinetic and thermodynamic conditions result in SOD increasing the flux of H(2)O(2).	Water	210-215	superoxide dismutase 1	Homo sapiens	183-186
17015180-6	2006	We found that SOD could change the rate of formation of H(2)O(2) in cases where equilibrium-specific reactions form superoxide with an equilibrium constant (K) less than 1.	Water	56-61	superoxide dismutase 1	Homo sapiens	14-17
16919340-2	2006	Four weeks" exposure of juvenile zebrafish (Danio rerio) to water-borne DE-71 resulted in dose-dependent induction of CYP1A immunoreactivity, predominantly in the endocardium and the endothelium of larger blood vessels, such as ventral aorta and branchial arteries, as well as the larger hepatic and pancreatic blood vessels.	Water	60-65	cytochrome P450, family 1, subfamily A	Danio rerio	118-123
17042615-2	2006	This new potential for liquid water describes the water-water interactions by a Lennard-Jones term and a sticky potential, which is an approximate moment expansion with point dipole, quadrupole, and octupole moments, and reproduces radial distribution functions of pure liquid water using the moments of SPC/E [Ichiye and Tan, J. Chem.	Water	30-35	proline rich protein gene cluster	Homo sapiens	304-307
17042615-2	2006	This new potential for liquid water describes the water-water interactions by a Lennard-Jones term and a sticky potential, which is an approximate moment expansion with point dipole, quadrupole, and octupole moments, and reproduces radial distribution functions of pure liquid water using the moments of SPC/E [Ichiye and Tan, J. Chem.	Water	50-55	proline rich protein gene cluster	Homo sapiens	304-307
17042615-2	2006	This new potential for liquid water describes the water-water interactions by a Lennard-Jones term and a sticky potential, which is an approximate moment expansion with point dipole, quadrupole, and octupole moments, and reproduces radial distribution functions of pure liquid water using the moments of SPC/E [Ichiye and Tan, J. Chem.	Water	50-55	proline rich protein gene cluster	Homo sapiens	304-307
17042615-2	2006	This new potential for liquid water describes the water-water interactions by a Lennard-Jones term and a sticky potential, which is an approximate moment expansion with point dipole, quadrupole, and octupole moments, and reproduces radial distribution functions of pure liquid water using the moments of SPC/E [Ichiye and Tan, J. Chem.	Water	50-55	proline rich protein gene cluster	Homo sapiens	304-307
17020387-3	2006	For these anions in five solvents, H2O, D2O, CH3OH, CH3CN, and (CH3)2SO, relaxation rates followed the trend of OCN- &gt; SCN- &gt; SeCN-.	Water	35-38	bone gamma-carboxyglutamate protein	Homo sapiens	112-115
17042615-7	2006	Here, various dynamical properties associated with translational and rotational motions of SSDQO water using the moments of SPC/E (SSDQO:SPC/E) water are compared with the results from SPC/E and also experiment.	Water	97-102	proline rich protein gene cluster	Homo sapiens	124-127
17042615-7	2006	Here, various dynamical properties associated with translational and rotational motions of SSDQO water using the moments of SPC/E (SSDQO:SPC/E) water are compared with the results from SPC/E and also experiment.	Water	97-102	proline rich protein gene cluster	Homo sapiens	137-140
17042615-7	2006	Here, various dynamical properties associated with translational and rotational motions of SSDQO water using the moments of SPC/E (SSDQO:SPC/E) water are compared with the results from SPC/E and also experiment.	Water	97-102	proline rich protein gene cluster	Homo sapiens	137-140
17042615-7	2006	Here, various dynamical properties associated with translational and rotational motions of SSDQO water using the moments of SPC/E (SSDQO:SPC/E) water are compared with the results from SPC/E and also experiment.	Water	144-149	proline rich protein gene cluster	Homo sapiens	137-140
17042615-7	2006	Here, various dynamical properties associated with translational and rotational motions of SSDQO water using the moments of SPC/E (SSDQO:SPC/E) water are compared with the results from SPC/E and also experiment.	Water	144-149	proline rich protein gene cluster	Homo sapiens	137-140
17042615-8	2006	The self-diffusion coefficient of SSDQO:SPC/E water is found to be in excellent agreement with both SPC/E and experiment whereas the single particle orientational relaxation time for dipole vector is better than SPC/E water but it is somewhat smaller than experiment.	Water	46-51	proline rich protein gene cluster	Homo sapiens	40-43
17042615-8	2006	The self-diffusion coefficient of SSDQO:SPC/E water is found to be in excellent agreement with both SPC/E and experiment whereas the single particle orientational relaxation time for dipole vector is better than SPC/E water but it is somewhat smaller than experiment.	Water	46-51	proline rich protein gene cluster	Homo sapiens	100-103
17042615-8	2006	The self-diffusion coefficient of SSDQO:SPC/E water is found to be in excellent agreement with both SPC/E and experiment whereas the single particle orientational relaxation time for dipole vector is better than SPC/E water but it is somewhat smaller than experiment.	Water	46-51	proline rich protein gene cluster	Homo sapiens	100-103
17068603-3	2006	The speckle pattern fluctuations are related to the water content of the sap, which is in the veinous structure of a leaf.	Water	52-57	SH2 domain containing 1A	Homo sapiens	73-76
16930632-5	2006	This prompted us to study the association of three p53 polymorphisms with arsenic induced keratosis in a population exposed to arsenic through drinking water.	Water	152-157	tumor protein p53	Homo sapiens	51-54
17014133-0	2006	Mechanical properties of interfacial films formed by lysozyme self-assembly at the air-water interface.	Water	87-92	lysozyme	Homo sapiens	53-61
17014133-1	2006	We present the first characterization of the mechanical properties of lysozyme films formed by self-assembly at the air-water interface using the Cambridge interfacial tensiometer (CIT), an apparatus capable of subjecting protein films to a much higher level of extensional strain than traditional dilatational techniques.	Water	120-125	lysozyme	Homo sapiens	70-78
17014133-4	2006	We have also identified a previously undescribed pH dependency in the effect of solution ionic strength on the mechanical strength of the lysozyme films formed at the air-water interface.	Water	171-176	lysozyme	Homo sapiens	138-146
16970944-9	2006	Our results suggest that transactivation of EGFR by IGF-1 requires basal intracellular H(2)O(2) in DU145 cells.	Water	87-92	epidermal growth factor receptor	Homo sapiens	44-48
17029445-0	2006	Direct ab initio molecular dynamics study on a microsolvated SN2 reaction of OH-(H2O) with CH3Cl.	Water	81-84	solute carrier family 38 member 5	Homo sapiens	61-64
17029445-1	2006	Reaction dynamics for a microsolvated SN2 reaction OH-(H2O)+CH3Cl have been investigated by means of the direct ab initio molecular dynamics method.	Water	55-59	solute carrier family 38 member 5	Homo sapiens	38-41
16970944-9	2006	Our results suggest that transactivation of EGFR by IGF-1 requires basal intracellular H(2)O(2) in DU145 cells.	Water	87-92	insulin like growth factor 1	Homo sapiens	52-57
17004906-7	2006	Feeding coconut water resulted in increased activities of 3-hydroxy-3-methylglutaryl-CoA reductase in liver, lipoprotein lipase in heart and adipose tissue, and plasma lecithin:cholesterol acyl transferase, while lipogenic enzymes showed decreased activities.	Water	16-21	lipoprotein lipase	Rattus norvegicus	109-127
16645161-10	2006	The data suggested that IL-1beta reduces LES tone by producing H(2)O(2), which may affect Ca(2+)-release mechanisms and increase the synthesis of COX-2 and PGE(2).	Water	63-68	interleukin 1 beta	Felis catus	24-32
16875815-1	2006	A water-soluble albumin-binding prodrug of doxorubicin [EMC-Gly-Gly-Gly-Arg-Arg-DOXO (EMC, 6-maleimidocaproic acid)] was developed that is cleaved specifically by the tumor-associated protease urokinase-type plasminogen activator (uPA).	Water	2-7	plasminogen activator, urokinase	Homo sapiens	193-229
16875815-1	2006	A water-soluble albumin-binding prodrug of doxorubicin [EMC-Gly-Gly-Gly-Arg-Arg-DOXO (EMC, 6-maleimidocaproic acid)] was developed that is cleaved specifically by the tumor-associated protease urokinase-type plasminogen activator (uPA).	Water	2-7	plasminogen activator, urokinase	Homo sapiens	231-234
17025356-1	2006	The secondary structure of organophosphorus hydrolase (OPH) at the air-water interface was studied using polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS).	Water	71-76	acylaminoacyl-peptide hydrolase	Homo sapiens	55-58
17025356-7	2006	The compression and decompression of the OPH monolayer indicated that the fingerprint of the secondary structure at the air-water interface was reversible.	Water	124-129	acylaminoacyl-peptide hydrolase	Homo sapiens	41-44
17025356-9	2006	The secondary structure of OPH at the air-water interface was well defined when the pH of the subphase was near its isoelectric point (IP, pH 7.6).	Water	42-47	acylaminoacyl-peptide hydrolase	Homo sapiens	27-30
17025356-11	2006	The hydrolysis of organophosphorus compound paraoxon by OPH was also studied at the air-water interface by PM-IRRAS.	Water	88-93	acylaminoacyl-peptide hydrolase	Homo sapiens	56-59
17093401-3	2006	The activity of GAPDH in the water-soluble fraction after incubation with or without Trx or/and TrxR for 60 min at 30 degrees C was measured spectrophotometrically.	Water	29-34	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	16-21
16942765-1	2006	It has been shown that aquaporin-3, a water channel, is expressed in mouse embryos.	Water	38-43	aquaporin 3	Mus musculus	23-34
17012249-6	2006	2) pCMBS, an inhibitor of the AQP1 water channel, reduces P(CO2) of RBCs solely by action on AQP1 as it has no effect in AQP1-deficient RBCs.	Water	35-40	aquaporin 1 (Colton blood group)	Homo sapiens	30-34
16927075-1	2006	OBJECTIVE: The aim of this study was to investigate the impact of the water-soluble poly-(ADP)-ribose-polymerase (PARP) inhibitor 5-aminoisoquinolinone (5-AIQ) on liver microcirculation and function after haemorrhagic shock and resuscitation.	Water	70-75	poly(ADP-ribose) polymerase 1	Homo sapiens	114-118
17016551-3	2006	show that, in jejunum of mice injected with anti-CD3 or with TNF, fluid accumulation and changes in epithelial phenotype develop, the latter including an increase in the passive permeability to proteins, smaller solutes, and water and the endocytosis of the brush border Na+/H+ exchanger, thereby inhibiting Na+ absorption (a second cytokine, LIGHT, has the former effect, but not the latter) (see the related article beginning on page 2682).	Water	225-230	tumor necrosis factor	Mus musculus	61-64
17016558-3	2006	In contrast, although TNF-neutralizing antibodies completely restore water absorption after systemic T cell activation, barrier function is only partially corrected.	Water	69-74	tumor necrosis factor	Homo sapiens	22-25
17016558-11	2006	These data demonstrate the necessity of coordinated Na+ malabsorption and barrier dysfunction in TNF-induced diarrhea and provide insight into mechanisms of intestinal water transport.	Water	168-173	tumor necrosis factor	Homo sapiens	97-100
16933093-1	2006	PURPOSE: This paper presents the first detailed kinetic investigation involving the continuous measurement of the soybean lipoxygenase 1 (LOX1)-catalyzed oxidation of unsaturated lipids using the monomolecular film technique at an argon/water interface.	Water	237-242	seed linoleate 13S-lipoxygenase-1	Glycine max	122-136
16954136-5	2006	NIP2;1 expressed in yeast cells had low water channel activity in the membranes.	Water	40-45	NOD26-like intrinsic protein 2;1	Arabidopsis thaliana	0-6
16877677-5	2006	The CFTR is a cAMP-regulated chloride channel that functions to regulate salt and water content in glands and ducts of secretory epithelia.	Water	82-87	CF transmembrane conductance regulator	Homo sapiens	4-8
16954136-6	2006	NIP2;1 may function as a water channel and/or ER channel for other small molecules or ions.	Water	25-30	NOD26-like intrinsic protein 2;1	Arabidopsis thaliana	0-6
16933093-1	2006	PURPOSE: This paper presents the first detailed kinetic investigation involving the continuous measurement of the soybean lipoxygenase 1 (LOX1)-catalyzed oxidation of unsaturated lipids using the monomolecular film technique at an argon/water interface.	Water	237-242	seed linoleate 13S-lipoxygenase-1	Glycine max	138-142
16961387-4	2006	Compound 2 with a H2O molecule coordinated to Pb(II) was prepared by a hydrothermal reaction.	Water	18-21	submaxillary gland androgen regulated protein 3B	Homo sapiens	46-52
17044001-2	2006	At present, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules (AQP0, AQP1, AQP2, AQP4, AQP5, AQP6, and AQP8), or also glycerol and other small solutes (AQP3, AQP7, AQP9, AQP10, AQP12).	Water	121-126	aquaporin 8	Homo sapiens	178-182
17044001-2	2006	At present, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules (AQP0, AQP1, AQP2, AQP4, AQP5, AQP6, and AQP8), or also glycerol and other small solutes (AQP3, AQP7, AQP9, AQP10, AQP12).	Water	121-126	aquaporin 9	Homo sapiens	239-243
16971984-1	2006	We report a Molecular Dynamics (MD) study of the interface between water and the hygroscopic room temperature Ionic Liquid "IL" [BMI][PF6] (1-butyl-3-methyl-imidazolium hexafluorophosphate), comparing the TIP3P, SPC/E and TIP5P models for water and two IL models where the ions are +/-1 or +/-0.9 charged.	Water	67-72	proline rich protein gene cluster	Homo sapiens	212-215
16946699-4	2006	The structures reveal that WDR5 is able to bind all of these histone H3 peptides, but only H3K4me2 peptide forms extra interactions with WDR5 by use of both water-mediated hydrogen bonding and the altered hydrophilicity of the modified lysine 4.	Water	157-162	WD repeat domain 5	Homo sapiens	137-141
16889783-1	2006	A separation and determination method for the analysis of cyanometallic complexes of Fe(II), Ni(II) and Co(III) was developed to be applied to the analysis of petroleum refinery streams (sour water).	Water	192-197	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	104-111
16948809-1	2006	BACKGROUND: RWJ-351647 is a selective V2 receptor antagonist that inhibits vasopressin-induced water reabsorption in the kidney.	Water	95-100	arginine vasopressin	Homo sapiens	75-86
17343172-6	2006	Mothers who got their drinking water from river or pond during periconceptional period were more likely to have a NTD-affected pregnancy [OR = 3.42, 95% CI: 1.44-8.09, population attributable risk (PAR) = 4.7%] compared with those who utilized tap or well water.	Water	31-36	SEC14 like lipid binding 2	Homo sapiens	244-247
16931995-2	2006	Three subtypes of vasopressin receptors, V1, V2, and V3, have been identified, mediating vasoconstriction, water reabsorption, and central nervous system effects, respectively.	Water	107-112	arginine vasopressin	Homo sapiens	18-29
16601259-4	2006	The role of angiotensin was not specific for cocaine, because ANG II (icv) pretreatment before startle with cold water (1 cm deep) enhanced the decrease in CO and the increase in SVR in both MR and VR, whereas losartan (icv) pretreatment before startle attenuated the decrease in CO and the increase in SVR in VR so that they were no longer different from MR.	Water	113-118	angiotensinogen	Rattus norvegicus	62-68
16942107-7	2006	The SPC/E water model performs best with all three biomolecular force fields.	Water	10-15	proline rich protein gene cluster	Homo sapiens	4-7
16831551-2	2006	The synthesis and optimization of a cyclopentane-based hNK1 antagonist scaffold 3, having four chiral centers, will be discussed in the context of its enhanced water solubility properties relative to the marketed anti-emetic hNK1 antagonist EMEND (Aprepitant).	Water	160-165	beta-1,3-glucuronyltransferase 1	Homo sapiens	55-59
16806914-0	2006	Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors.	Water	28-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	106-122
16806914-0	2006	Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors.	Water	28-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	124-129
16912214-4	2006	The computational results confirm our previous suggestion, which was based on QM calculations on a simplified active site model, that BL2 in PDE4 should be HO-, rather than H2O, serving as the nucleophile to initialize the catalytic hydrolysis of cAMP.	Water	173-176	cell adhesion molecule 1	Homo sapiens	134-137
16843671-5	2006	Our results indicate that both the inclusion of the structural water molecules close to the ions in the binding site and the use of a free energy model with a quadratic dependency on the ligand free energy of solvation are important aspects to be considered for molecular docking investigations involving the PDE4 enzyme family.	Water	63-68	phosphodiesterase 4A	Homo sapiens	309-313
16912214-4	2006	The computational results confirm our previous suggestion, which was based on QM calculations on a simplified active site model, that BL2 in PDE4 should be HO-, rather than H2O, serving as the nucleophile to initialize the catalytic hydrolysis of cAMP.	Water	173-176	phosphodiesterase 4A	Homo sapiens	141-145
16912214-5	2006	The molecular dynamics simulations and QM/MM calculations on PDE5 demonstrate for the first time that the BL2 in PDE5 should also be HO- rather than H2O as proposed in recently published reports on the x-ray crystal structures, which serves as the nucleophile to initialize the PDE5-catalyzed hydrolysis of cGMP.	Water	149-152	cell adhesion molecule 1	Homo sapiens	106-109
16912214-5	2006	The molecular dynamics simulations and QM/MM calculations on PDE5 demonstrate for the first time that the BL2 in PDE5 should also be HO- rather than H2O as proposed in recently published reports on the x-ray crystal structures, which serves as the nucleophile to initialize the PDE5-catalyzed hydrolysis of cGMP.	Water	149-152	phosphodiesterase 5A	Homo sapiens	113-117
16912214-5	2006	The molecular dynamics simulations and QM/MM calculations on PDE5 demonstrate for the first time that the BL2 in PDE5 should also be HO- rather than H2O as proposed in recently published reports on the x-ray crystal structures, which serves as the nucleophile to initialize the PDE5-catalyzed hydrolysis of cGMP.	Water	149-152	phosphodiesterase 5A	Homo sapiens	113-117
16806914-1	2006	In an attempt to prepare a new water-soluble, parenteral COX-2 inhibitor, rofecoxib (9) and celecoxib (13) analogues were designed and synthesized for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors with in vivo anti-inflammatory activity.	Water	31-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	57-62
16806914-1	2006	In an attempt to prepare a new water-soluble, parenteral COX-2 inhibitor, rofecoxib (9) and celecoxib (13) analogues were designed and synthesized for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors with in vivo anti-inflammatory activity.	Water	31-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	175-191
16961492-1	2006	Because of the ubiquitous nature of anthropogenic nitrate (NO3(-)) in many parts of the world, determining background concentrations of NO3(-) in shallow ground water from natural sources is probably impossible in most environments.	Water	161-166	NBL1, DAN family BMP antagonist	Homo sapiens	136-139
17009073-7	2006	Abnormalities in water channels aquaporin (AQP)1 and AQP2, as well as in the vasopressin receptor V2R, are known to cause nephrogenic diabetes insipidus.	Water	17-22	aquaporin 1 (Colton blood group)	Homo sapiens	43-48
16728491-9	2006	These data demonstrate that NPY Y1R gene and protein expression are increased in the SON of salt-loaded and water-deprived animals and provide a mechanism whereby NPY can support VP/OT release during prolonged challenges to fluid homeostasis.	Water	108-113	neuropeptide Y	Rattus norvegicus	28-31
16728491-9	2006	These data demonstrate that NPY Y1R gene and protein expression are increased in the SON of salt-loaded and water-deprived animals and provide a mechanism whereby NPY can support VP/OT release during prolonged challenges to fluid homeostasis.	Water	108-113	neuropeptide Y	Rattus norvegicus	163-166
16919017-2	2006	ET-1 exerts a wide variety of biological effects, including constriction of cortical and medullary vessels, mesangial cell contraction, stimulation of extracellular matrix production, and inhibition of sodium and water reabsorption along the collecting duct, effects that are primarily mediated in an autocrine/paracrine manner.	Water	213-218	endothelin 1	Homo sapiens	0-4
17057261-9	2006	The standard curve for the DHP-Fe complex was linear between 0.01 and 400 microMin water as well as in plasma, bronchoalveolar lavage, brain tissue, and amniotic fluid.	Water	83-88	dihydropyrimidinase	Homo sapiens	27-30
16765972-9	2006	The PLA(2) concentration series is measured in the absence and presence of beta-cyclodextrin which forms water soluble complexes with the reaction products.	Water	105-110	phospholipase A2 group IB	Homo sapiens	4-10
16772346-5	2006	Perfusion and oxidative capacity were measured during insulin stimulation by [15O]H2O and [15O]O2.	Water	82-85	insulin	Homo sapiens	54-61
16973513-10	2006	Patients with positive CRP had higher ECFv/total body water (TBW) ratio (women 47.69 +/- 0.69 vs 47.36 +/- 0.65, men 43.15 +/- 1.14 vs 42.84 +/- 0.65; p &lt; 0.05), higher serum glucose (125.09 +/- 81.90 vs 103.28 +/- 43.30 mg/dL, p &lt; 0.03), and lower serum albumin (2.86 +/- 0.54 vs 3.17 +/- 0.38 g/dL, p &lt; 0.001) levels.	Water	54-59	C-reactive protein	Homo sapiens	23-26
16919536-2	2006	Glucose ingestion (75 g in 300 mL water) in healthy human subjects resulted in an increase in intranuclear nuclear factor kappaB (NF-kappaB) binding, the reduction of inhibitor kappaB alpha (IkappaBalpha) protein, and an increase in the activity of inhibitor kappaB kinase (IKK) and the expression of IKKalpha and IKKbeta, the enzymes that phosphorylate IkappaBalpha, in MNCs.	Water	34-39	NFKB inhibitor alpha	Homo sapiens	191-203
17004859-1	2006	Water balance is precisely regulated by vasopressin, thirst and the kidneys; plasma osmolality is maintained within a narrow range, despite large variations in normal water intake and loss.	Water	0-5	arginine vasopressin	Homo sapiens	40-51
16766718-6	2006	Intrathecal administration of N/OFQ dose dependently (10-100 nmol) produced long-lasting antinociception against a noxious stimulus, 50 degrees C water, and did not elicit itch/scratching responses in monkeys.	Water	146-151	prepronociceptin	Homo sapiens	30-35
17017983-11	2006	In contrast lornoxicam and meloxicam, which demonstrated activity against COX-2, have revealed smaller partition capacity in liposomes/water systems together with a higher ability to change the membrane fluidity and surface potential.	Water	135-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
16919536-2	2006	Glucose ingestion (75 g in 300 mL water) in healthy human subjects resulted in an increase in intranuclear nuclear factor kappaB (NF-kappaB) binding, the reduction of inhibitor kappaB alpha (IkappaBalpha) protein, and an increase in the activity of inhibitor kappaB kinase (IKK) and the expression of IKKalpha and IKKbeta, the enzymes that phosphorylate IkappaBalpha, in MNCs.	Water	34-39	nuclear factor kappa B subunit 1	Homo sapiens	122-128
16919536-2	2006	Glucose ingestion (75 g in 300 mL water) in healthy human subjects resulted in an increase in intranuclear nuclear factor kappaB (NF-kappaB) binding, the reduction of inhibitor kappaB alpha (IkappaBalpha) protein, and an increase in the activity of inhibitor kappaB kinase (IKK) and the expression of IKKalpha and IKKbeta, the enzymes that phosphorylate IkappaBalpha, in MNCs.	Water	34-39	nuclear factor kappa B subunit 1	Homo sapiens	130-139
16919536-2	2006	Glucose ingestion (75 g in 300 mL water) in healthy human subjects resulted in an increase in intranuclear nuclear factor kappaB (NF-kappaB) binding, the reduction of inhibitor kappaB alpha (IkappaBalpha) protein, and an increase in the activity of inhibitor kappaB kinase (IKK) and the expression of IKKalpha and IKKbeta, the enzymes that phosphorylate IkappaBalpha, in MNCs.	Water	34-39	NFKB inhibitor alpha	Homo sapiens	177-204
16919536-2	2006	Glucose ingestion (75 g in 300 mL water) in healthy human subjects resulted in an increase in intranuclear nuclear factor kappaB (NF-kappaB) binding, the reduction of inhibitor kappaB alpha (IkappaBalpha) protein, and an increase in the activity of inhibitor kappaB kinase (IKK) and the expression of IKKalpha and IKKbeta, the enzymes that phosphorylate IkappaBalpha, in MNCs.	Water	34-39	nuclear factor kappa B subunit 1	Homo sapiens	133-139
17005368-3	2006	in the striatum of rats exposed prenatally to both ethanol and cadmium, vs. a 2000% evoked release by AMPH in rats exposed prenatally to only ethanol or cadmium or tap water.	Water	168-173	nuclear RNA export factor 1	Rattus norvegicus	164-167
16927973-0	2006	Luminescent properties of water-soluble denatured bovine serum albumin-coated CdTe quantum dots.	Water	26-31	albumin	Homo sapiens	57-70
16455289-6	2006	The proposed method offers the potential advantages of high sensitivity, simplicity and rapidity for Co(II) and Cr(III) determination, and was successfully applied to the simultaneous determination of both analytes in real water sample.	Water	223-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
17058453-5	2006	According to the same protocol, the rats in the second group were treated with tap water containing 20 mg/kg RVT.	Water	83-88	nuclear RNA export factor 1	Rattus norvegicus	79-82
16943565-6	2006	Finally, TRPV1-/- mice showed significantly attenuated water intake in response to systemic hypertonicity compared with WT controls.	Water	55-60	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	9-14
16927973-1	2006	Chemically reduced bovine serum albumin (BSA) has been used to modify the surface of water-soluble CdTe quantum dots (QDs).	Water	85-90	albumin	Homo sapiens	26-39
16624989-9	2006	Aquaporin-8 and -9 channels have been identified in the inner mitochondrial membrane of various tissues, including the kidney, liver, and brain, where they may mediate water transport associated with physiological volume changes, contribute to the transport of metabolic substrates, and/or participate in osmotic swelling induced by apoptotic stimuli.	Water	168-173	aquaporin 8	Homo sapiens	0-18
16910672-6	2006	The mechanism for addition of water and methanol (ROH; R = H, Me) to 4, 5, and the model compound 1,1-bis(silyl)-2,2-dimethylsilene (3a) has been studied computationally at the B3LYP/6-31G(d) and MP2/6-31G(d) levels of theory.	Water	30-35	major intrinsic protein of lens fiber	Homo sapiens	196-201
16898772-1	2006	We report the four diffusion coefficients for the lysozyme-MgCl2-water ternary system at 25 degrees C and pH 4.5.	Water	65-70	lysozyme	Homo sapiens	50-58
16898772-2	2006	The comparison with previous results for the lysozyme-NaCl-water ternary system is used to examine the effect of salt stoichiometry on the transport properties of lysozyme-salt aqueous mixtures.	Water	59-64	lysozyme	Homo sapiens	163-171
16893168-2	2006	Here, the Ca(2+)-dependent membrane interactions of a water soluble fragment of synaptotagmin I (C2AB) that contains its two C2 domains (C2A and C2B) were determined using site-directed spin labeling.	Water	54-59	secretoglobin family 2B member 3, pseudogene	Homo sapiens	145-148
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Water	276-281	lactoperoxidase	Homo sapiens	485-488
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Water	276-281	lactoperoxidase	Homo sapiens	500-503
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Water	346-351	lactoperoxidase	Homo sapiens	485-488
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Water	346-351	lactoperoxidase	Homo sapiens	500-503
16878957-3	2006	Thus, Cl-, Br-, I-, and SO4(2-), in the presence of BPU and Zn2+, form MOFs from water, in which the anions coordinate the zinc and are hydrogen-bonded to the urea groups, whereas NO3- and ClO4- anions either do not form MOFs or form water-soluble discrete coordination complexes under the same conditions.	Water	81-86	NBL1, DAN family BMP antagonist	Homo sapiens	180-183
16867259-0	2006	Induction of murine interleukin-1 beta expression by water-soluble components from Hericium erinaceum.	Water	53-58	interleukin 1 beta	Mus musculus	20-38
16867259-1	2006	AIM: To investigate the inductive effect of water extract from Hericium erinaceum (WEHE) on interleukin-1beta (IL-1beta) expression.	Water	44-49	interleukin 1 beta	Mus musculus	111-119
16525162-1	2006	Aquaporin-1 (AQP1) and aquaporin-3 (AQP3) water channels expressed in the kidney play a critical role in the urine concentrating mechanism.	Water	42-47	aquaporin 3	Mus musculus	23-34
16525162-1	2006	Aquaporin-1 (AQP1) and aquaporin-3 (AQP3) water channels expressed in the kidney play a critical role in the urine concentrating mechanism.	Water	42-47	aquaporin 3	Mus musculus	36-40
16525162-11	2006	This solute-selective response could result from the capacity of AQP3 to transport not only water but also urea.	Water	92-97	aquaporin 3	Mus musculus	65-69
16825342-2	2006	Binding of this hormone to the vasopressin V2 receptor (V2R) leads to insertion of aquaporin-2 (AQP2) water channels in the apical membrane, thereby allowing water reabsorption from the pro-urine to the interstitium.	Water	102-107	arginine vasopressin receptor 2	Homo sapiens	31-54
16825342-2	2006	Binding of this hormone to the vasopressin V2 receptor (V2R) leads to insertion of aquaporin-2 (AQP2) water channels in the apical membrane, thereby allowing water reabsorption from the pro-urine to the interstitium.	Water	102-107	arginine vasopressin receptor 2	Homo sapiens	56-59
16825342-2	2006	Binding of this hormone to the vasopressin V2 receptor (V2R) leads to insertion of aquaporin-2 (AQP2) water channels in the apical membrane, thereby allowing water reabsorption from the pro-urine to the interstitium.	Water	158-163	arginine vasopressin receptor 2	Homo sapiens	31-54
16825342-2	2006	Binding of this hormone to the vasopressin V2 receptor (V2R) leads to insertion of aquaporin-2 (AQP2) water channels in the apical membrane, thereby allowing water reabsorption from the pro-urine to the interstitium.	Water	158-163	arginine vasopressin receptor 2	Homo sapiens	56-59
16878876-0	2006	Air-water Henry"s law constants for PCB congeners: Experimental determination and modeling of structure-property relationship.	Water	4-9	pyruvate carboxylase	Homo sapiens	36-39
16515771-0	2006	AQP0-LTR of the Cat Fr mouse alters water permeability and calcium regulation of wild type AQP0.	Water	36-41	major intrinsic protein of lens fiber	Mus musculus	0-8
16830230-0	2006	Water-soluble formulation of Coenzyme Q10 inhibits Bax-induced destabilization of mitochondria in mammalian cells.	Water	0-5	BCL2 associated X, apoptosis regulator	Homo sapiens	51-54
16515771-0	2006	AQP0-LTR of the Cat Fr mouse alters water permeability and calcium regulation of wild type AQP0.	Water	36-41	major intrinsic protein of lens fiber	Mus musculus	0-4
16788862-5	2006	Furthermore, c-Myc expression repressed the activation of Akt induced by the toxic agents doxorubicin, cisplatin and H(2)O(2), and also by the physiological agonists PDGF and insulin.	Water	117-122	AKT serine/threonine kinase 1	Homo sapiens	58-61
16918709-2	2006	The most important physiological function of vasopressin is the maintenance of water homeostasis through interaction with V2 receptors in the kidney.	Water	79-84	arginine vasopressin	Homo sapiens	45-56
16648161-9	2006	This study suggests that the side of the alpha-helical AFP comprising the i + 4 and i + 8 Ala methyl groups could interact with the ice surface in the ice/water interface.	Water	155-160	alpha fetoprotein	Homo sapiens	55-58
16679359-9	2006	With fuzzy space diffusion in the order of four orders of magnitude lower than in water, triggering through LTCC alone was up to 5 ms slower than with the presence of a Na(+) channel and NCX.	Water	82-87	solute carrier family 8 member A1	Rattus norvegicus	187-190
16824482-1	2006	Respiratory heme-copper oxidases are integral membrane proteins that catalyze the reduction of molecular oxygen to water using electrons donated by either quinol (quinol oxidases) or cytochrome c (cytochrome c oxidases, CcOs).	Water	115-120	cytochrome c, somatic	Homo sapiens	183-195
16824482-1	2006	Respiratory heme-copper oxidases are integral membrane proteins that catalyze the reduction of molecular oxygen to water using electrons donated by either quinol (quinol oxidases) or cytochrome c (cytochrome c oxidases, CcOs).	Water	115-120	cytochrome c, somatic	Homo sapiens	197-209
16856835-5	2006	For example, AKAP-PKA interactions are essential for the vasopressin-mediated water re-absorption in renal collecting duct principal cells or beta-adrenoceptor-induced increases in cardiac myocyte contractility.	Water	78-83	arginine vasopressin	Homo sapiens	57-68
16872579-10	2006	AQP1, 5 are strictly water channels.	Water	21-26	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
16794787-1	2006	Effects of vasopressin via V1a- and V2-receptors are closely implicated in a variety of water-retaining diseases and cardiovascular diseases, including heart failure, hyponatraemia, hypertension, renal diseases, syndrome of inappropriate antidiuretic hormone secretion, cirrhosis and ocular hypertension.	Water	88-93	arginine vasopressin	Homo sapiens	11-22
16515771-1	2006	Aquaporin 0 (AQP0) is the major intrinsic protein of the lens and its water permeability can be modulated by changes in pH and Ca2+.	Water	70-75	major intrinsic protein of lens fiber	Mus musculus	0-11
16515771-1	2006	Aquaporin 0 (AQP0) is the major intrinsic protein of the lens and its water permeability can be modulated by changes in pH and Ca2+.	Water	70-75	major intrinsic protein of lens fiber	Mus musculus	13-17
16515771-6	2006	Second, we measured water permeability of AQP0 co-expressed with AQP0-LTR in Xenopus oocytes.	Water	20-25	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	42-46
16515771-6	2006	Second, we measured water permeability of AQP0 co-expressed with AQP0-LTR in Xenopus oocytes.	Water	20-25	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	65-73
16814974-10	2006	These results in human fetal brain lend morphological support to the previous findings that aquaporin-1 and aquaporin-4 play different roles in the regulation of the water homeostasis of the brain.	Water	166-171	aquaporin 1 (Colton blood group)	Homo sapiens	92-103
16515771-7	2006	A low expression level of AQP0-LTR decreased the water permeability of AQP0, and a high expression level eliminated its calcium regulation.	Water	49-54	major intrinsic protein of lens fiber	Mus musculus	26-34
16515771-7	2006	A low expression level of AQP0-LTR decreased the water permeability of AQP0, and a high expression level eliminated its calcium regulation.	Water	49-54	major intrinsic protein of lens fiber	Mus musculus	26-30
16515771-10	2006	The deleterious effect of AQP0-LTR on lens development may be explained by lowering water permeability and abolishing calcium regulation of AQP0.	Water	84-89	major intrinsic protein of lens fiber	Mus musculus	26-34
16515771-10	2006	The deleterious effect of AQP0-LTR on lens development may be explained by lowering water permeability and abolishing calcium regulation of AQP0.	Water	84-89	major intrinsic protein of lens fiber	Mus musculus	26-30
16515771-11	2006	This study provides the first evidence that calcium regulation of AQP0 water permeability may be crucial for maintaining normal lens homeostasis and development.	Water	71-76	major intrinsic protein of lens fiber	Mus musculus	66-70
16809436-2	2006	Here we determined the in vivo actions of MIF in regulating the physiological actions of ANG II that are mediated via the paraventricular nucleus (PVN), an area that serves as a relay point in the central nervous system (CNS)-mediated effects of ANG II on cardiovascular functions and water intake.	Water	285-290	macrophage migration inhibitory factor	Rattus norvegicus	42-45
16809436-2	2006	Here we determined the in vivo actions of MIF in regulating the physiological actions of ANG II that are mediated via the paraventricular nucleus (PVN), an area that serves as a relay point in the central nervous system (CNS)-mediated effects of ANG II on cardiovascular functions and water intake.	Water	285-290	angiotensinogen	Rattus norvegicus	89-95
16807543-8	2006	Infusion in rats produced conflicting results: exogenous UII has been shown to increase glomerular filtration rate (GFR) and excretion of water and sodium, but also to reduce the same variables.	Water	138-143	urotensin 2	Rattus norvegicus	57-60
17133770-3	2006	Environmentally induced alterations in p53 protein have been reported to contribute to pathogenesis of leukemia in soft-shell clam Mya arenaria inhabiting polluted water, suggesting that p53 proteins can also be used as pollution markers.	Water	164-169	tumor protein p53	Homo sapiens	39-42
16807403-4	2006	For suppression of the effect of AVP physiologically, water intake was increased in PCK rats, a model of PKD, and the effect on renal morphology, cellular mechanism, and function was determined.	Water	54-59	arginine vasopressin	Rattus norvegicus	33-36
16807403-6	2006	In PCK rats, increased water intake for 10 wk reduced urinary AVP excretion (68.3%), and urine osmolality fell below 290 mOsmol/kg.	Water	23-28	arginine vasopressin	Rattus norvegicus	62-65
16807403-7	2006	High water intake was associated with reduced renal expression of AVP V2 receptors (41.0%), B-Raf (15.4%), phosphorylated ERK (38.1%), and proliferating cell nuclear antigen-positive renal cells (61.7%).	Water	5-10	arginine vasopressin	Homo sapiens	66-69
16807403-7	2006	High water intake was associated with reduced renal expression of AVP V2 receptors (41.0%), B-Raf (15.4%), phosphorylated ERK (38.1%), and proliferating cell nuclear antigen-positive renal cells (61.7%).	Water	5-10	Eph receptor B1	Rattus norvegicus	122-125
16807403-9	2006	Taken together, these data demonstrate that water intake that is sufficient to cause persistent water diuresis suppresses B-Raf/MEK/ERK activity and decreases cyst and renal volumes in PCK rats.	Water	44-49	mitogen-activated protein kinase kinase 7	Homo sapiens	128-131
16807403-9	2006	Taken together, these data demonstrate that water intake that is sufficient to cause persistent water diuresis suppresses B-Raf/MEK/ERK activity and decreases cyst and renal volumes in PCK rats.	Water	44-49	Eph receptor B1	Rattus norvegicus	132-135
16807403-9	2006	Taken together, these data demonstrate that water intake that is sufficient to cause persistent water diuresis suppresses B-Raf/MEK/ERK activity and decreases cyst and renal volumes in PCK rats.	Water	96-101	mitogen-activated protein kinase kinase 7	Homo sapiens	128-131
16807403-9	2006	Taken together, these data demonstrate that water intake that is sufficient to cause persistent water diuresis suppresses B-Raf/MEK/ERK activity and decreases cyst and renal volumes in PCK rats.	Water	96-101	Eph receptor B1	Rattus norvegicus	132-135
16807403-10	2006	It is suggested that limiting serum AVP levels by increased water intake may be beneficial to some patients with PKD.	Water	60-65	arginine vasopressin	Homo sapiens	36-39
17217253-0	2006	[Psychomotor responsiveness to corticoliberin in rats with active and passive adaptive strategy in water-immersion paradigm of depression].	Water	99-104	corticotropin releasing hormone	Rattus norvegicus	31-45
16546240-1	2006	The use of a synthetically prepared clay material, hydrotalcite (HT), for the removal of arsenite (As(III)) and arsenate (As(V)) from drinking water is described.	Water	143-148	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	121-127
16691325-11	2006	Changes in BGE were better related to CNP stoichiometry in the water, and the "excess" of organic substrates was oxidized in catabolism, despite the quality of these compounds for bacterial growth.	Water	63-68	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	38-41
16815441-8	2006	The collapsed form of Bc-Csp resembles the unfolded form in its interaction with ethylene glycol, suggesting that in the collapsed form the backbone is still accessible to water and small molecules.	Water	172-177	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	25-28
16842004-3	2006	The reactions of H(3)CAM and H2PDA with Nd2O3 in the M/L ratio 2:3 gave {[Nd2(HCAM)3(H2O)4].2H2O}n (2) and {[Nd(2)(PDA)3(H2O)(3)].0.5H2O}n (2a).	Water	85-88	calmodulin 3	Homo sapiens	21-24
16848433-1	2006	An Ac-Ala-Ala-Ala-NH2 tripeptide was folded into a beta-turn structure even in water through hydrophobic binding by a self-assembled porphyrin cage.	Water	79-84	amyloid beta precursor protein	Homo sapiens	49-55
16848484-4	2006	Both the experimental and the theoretical results demonstrate that sn-1 carbonyl has a higher propensity to form hydrogen bonds with water in comparison to sn-2.	Water	133-138	solute carrier family 38 member 3	Homo sapiens	67-71
16616209-4	2006	In this study, using the neurosecretory cell line-PC12 cells to set up the model of neuroprotection of preconditioning with H(2)O(2) against apoptosis, we first investigate what changes in expression of iNOS and COX-2 appear during H(2)O(2) preconditioning, then determine if both iNOS inhibitor and COX-2 inhibitor interfere with the neuroprotection elicited by preconditioning with H(2)O(2).	Water	124-129	nitric oxide synthase 2	Rattus norvegicus	203-207
16616209-4	2006	In this study, using the neurosecretory cell line-PC12 cells to set up the model of neuroprotection of preconditioning with H(2)O(2) against apoptosis, we first investigate what changes in expression of iNOS and COX-2 appear during H(2)O(2) preconditioning, then determine if both iNOS inhibitor and COX-2 inhibitor interfere with the neuroprotection elicited by preconditioning with H(2)O(2).	Water	124-129	nitric oxide synthase 2	Rattus norvegicus	281-285
16616209-5	2006	We found that preconditioning with H(2)O(2) at 10 microM significantly protected PC12 cells against apoptosis induced by lethal H(2)O(2) (50 microM) and increased the expression of iNOS and COX-2 and that selective iNOS inhibitor, aminoguanidine (AG) and COX-2 inhibitor, NS-398 obviously blocked the protective effects induced by preconditioning with 10 microM H(2)O(2).	Water	35-40	nitric oxide synthase 2	Rattus norvegicus	181-185
16616209-5	2006	We found that preconditioning with H(2)O(2) at 10 microM significantly protected PC12 cells against apoptosis induced by lethal H(2)O(2) (50 microM) and increased the expression of iNOS and COX-2 and that selective iNOS inhibitor, aminoguanidine (AG) and COX-2 inhibitor, NS-398 obviously blocked the protective effects induced by preconditioning with 10 microM H(2)O(2).	Water	35-40	nitric oxide synthase 2	Rattus norvegicus	215-219
16854039-2	2006	The fully optimized complexes of fac-[Tc(OH(2))(CO(3))](+) and mer-[Tc(OH(2))(CO(3))](+) show geometries that compare favorably with the X-ray data.	Water	41-47	FA complementation group C	Homo sapiens	33-36
16854039-2	2006	The fully optimized complexes of fac-[Tc(OH(2))(CO(3))](+) and mer-[Tc(OH(2))(CO(3))](+) show geometries that compare favorably with the X-ray data.	Water	71-77	FA complementation group C	Homo sapiens	33-36
16842004-6	2006	It is interesting to note that, when Ln(III) salts rather than oxides were employed, the reaction produced {[Ln(CAM)(H2O)3].H2O}n (Ln = Gd, 3; Dy, 4; Er, 5) for H(3)CAM and {[Gd2(PDA)3(H2O)3].H2O}n (3a) for H2PDA.	Water	117-120	calmodulin 3	Homo sapiens	112-115
16842004-6	2006	It is interesting to note that, when Ln(III) salts rather than oxides were employed, the reaction produced {[Ln(CAM)(H2O)3].H2O}n (Ln = Gd, 3; Dy, 4; Er, 5) for H(3)CAM and {[Gd2(PDA)3(H2O)3].H2O}n (3a) for H2PDA.	Water	117-120	calmodulin 3	Homo sapiens	165-168
16842004-6	2006	It is interesting to note that, when Ln(III) salts rather than oxides were employed, the reaction produced {[Ln(CAM)(H2O)3].H2O}n (Ln = Gd, 3; Dy, 4; Er, 5) for H(3)CAM and {[Gd2(PDA)3(H2O)3].H2O}n (3a) for H2PDA.	Water	124-127	calmodulin 3	Homo sapiens	112-115
16842004-6	2006	It is interesting to note that, when Ln(III) salts rather than oxides were employed, the reaction produced {[Ln(CAM)(H2O)3].H2O}n (Ln = Gd, 3; Dy, 4; Er, 5) for H(3)CAM and {[Gd2(PDA)3(H2O)3].H2O}n (3a) for H2PDA.	Water	124-127	calmodulin 3	Homo sapiens	165-168
16842004-6	2006	It is interesting to note that, when Ln(III) salts rather than oxides were employed, the reaction produced {[Ln(CAM)(H2O)3].H2O}n (Ln = Gd, 3; Dy, 4; Er, 5) for H(3)CAM and {[Gd2(PDA)3(H2O)3].H2O}n (3a) for H2PDA.	Water	124-127	calmodulin 3	Homo sapiens	112-115
16842004-6	2006	It is interesting to note that, when Ln(III) salts rather than oxides were employed, the reaction produced {[Ln(CAM)(H2O)3].H2O}n (Ln = Gd, 3; Dy, 4; Er, 5) for H(3)CAM and {[Gd2(PDA)3(H2O)3].H2O}n (3a) for H2PDA.	Water	124-127	calmodulin 3	Homo sapiens	165-168
16821769-2	2006	Compounds 9a and the water soluble analogue11e were found to be potent PPARgamma agonists.	Water	21-26	peroxisome proliferator activated receptor gamma	Homo sapiens	71-80
16865795-0	2006	Comment on: cloning and characterization of porcine aquaporin 1 water channel expressed extensively in the gastrointestinal system.	Water	64-69	aquaporin 1 (Colton blood group)	Homo sapiens	52-63
21690842-3	2006	A special class of enzymes, the phospholipases, and in particular secretory phospholipase A(2) (sPLA(2)), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids.	Water	150-155	phospholipase A2 group X	Homo sapiens	66-94
21690842-3	2006	A special class of enzymes, the phospholipases, and in particular secretory phospholipase A(2) (sPLA(2)), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids.	Water	150-155	phospholipase A2 group X	Homo sapiens	96-103
16678417-2	2006	Esterification with inorganic phosphate and conversion to the sodium salt produced compounds (lutein diphosphate sodium salt; "LdP") capable of forming red-orange aqueous suspensions after addition to USP-purified water.	Water	214-219	carboxypeptidase Q	Homo sapiens	127-130
16756992-0	2006	Water transport in AQP0 aquaporin: molecular dynamics studies.	Water	0-5	major intrinsic protein of lens fiber	Homo sapiens	19-23
16756992-8	2006	The simulations demonstrate that AQP0, in single or double lipid bilayers, is not closed to water transport and that thermal motions of critical side-chains are sufficient to facilitate the movement of water past any of its constriction regions.	Water	202-207	major intrinsic protein of lens fiber	Homo sapiens	33-37
16756992-9	2006	These motional requirements do however lead to significant free energy barriers and help explain physiological observations that found water permeability in AQP0 to be substantially lower than in the AQP1 pore.	Water	135-140	major intrinsic protein of lens fiber	Homo sapiens	157-161
16863305-1	2006	We present our calculations of the cross second virial coefficient (B12) and of a related quantity, phi 12 = B12-TdB12/dT, for the methane-water system in the temperature range T = 200-1000 K. These calculations were performed using one of the ab initio potentials developed in previous work [Akin-Ojo and Szalewicz, J. Chem.	Water	139-144	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	68-71
16863305-1	2006	We present our calculations of the cross second virial coefficient (B12) and of a related quantity, phi 12 = B12-TdB12/dT, for the methane-water system in the temperature range T = 200-1000 K. These calculations were performed using one of the ab initio potentials developed in previous work [Akin-Ojo and Szalewicz, J. Chem.	Water	139-144	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	109-112
16756992-3	2006	The subsequent determination of a high-resolution AQP0 tetramer structure by X-ray crystallographic methods yielded a pore model featuring two of the three constrictions as noted in the EM work and water molecules within the channel pore.	Water	198-203	major intrinsic protein of lens fiber	Homo sapiens	50-54
16756992-4	2006	The extracellular-side constriction region of this AQP0 structure was significantly larger than that of the EM-based model and similar to that of the highly water permeable AQP1.	Water	157-162	major intrinsic protein of lens fiber	Homo sapiens	51-55
16756992-4	2006	The extracellular-side constriction region of this AQP0 structure was significantly larger than that of the EM-based model and similar to that of the highly water permeable AQP1.	Water	157-162	aquaporin 1 (Colton blood group)	Homo sapiens	173-177
16843085-7	2006	The role of the nonosmotic AVP release in water retention and hypo-osmolality/hyponatremia has been demonstrated in patients and experimental animals by administering nonpeptide, orally active vasopressin V2 receptor antagonists.	Water	42-47	arginine vasopressin receptor 2	Homo sapiens	193-216
16843091-2	2006	It is a state of relative water excess due to stimulated arginine vasopressin (AVP) and fluid intake greater than obligatory losses.	Water	26-31	arginine vasopressin	Homo sapiens	66-77
16481371-5	2006	The water channel, aquaporin (AQP) 1, was predominantly situated in the apical plasma membrane domain, although distinct basolateral and endothelial immunoreactivity was also observed.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	30-36
16449354-1	2006	Vasopressin increases urine concentration by stimulating plasma membrane accumulation of aquaporin-2 (AQP2) in collecting duct principal cells, allowing bulk water flow across the collecting duct from lumen to interstitium down an osmotic gradient.	Water	158-163	arginine vasopressin	Rattus norvegicus	0-11
16405955-2	2006	In the reported study, a novel sorbent, a waste by-product of the drinking-water treatment process, namely, drinking-water treatment residuals (WTRs) were evaluated for their ability to adsorb both As(V) and As(III).	Water	75-80	WTRS	Homo sapiens	144-148
16453305-5	2006	Based on the data for fluorescence quenching in solvents of different polarity, the dipole moments in the intermolecular charge transfer S(1) state have been obtained for carotenoids (peridinin, fucoxanthin, uriolide acetate) and for hydrogen-bonding complexes, which are formed by 4-amino-, 4-methylamino-, and 4-dimethylamino-N-methylphthalimides in alcohols and water.	Water	365-370	proteasome 26S subunit, non-ATPase 1	Homo sapiens	137-141
17369888-1	2006	Systemic administration of angiotensin II after carotid glomectomy produced a less pronounced dipsogenic effects (consumption of water and NaCl solution) compared to sham-operated control animals.	Water	129-134	angiotensinogen	Rattus norvegicus	27-41
17369888-2	2006	Injection of angiotensin II into the lateral cerebral ventricles of the same glomectomized rats increased water and NaCl consumption to a level surpassing that of sham-operated animals.	Water	106-111	angiotensinogen	Rattus norvegicus	13-27
16494987-7	2006	As expected, expression of human T2R4 or its mouse ortholog T2R8 in ASI neurons counteracted the water-soluble avoidance to 6-n-propyl-2-thiouracil and denatoniun observed in control wild-type worms.	Water	97-102	taste 2 receptor member 4	Homo sapiens	33-37
16405955-2	2006	In the reported study, a novel sorbent, a waste by-product of the drinking-water treatment process, namely, drinking-water treatment residuals (WTRs) were evaluated for their ability to adsorb both As(V) and As(III).	Water	117-122	WTRS	Homo sapiens	144-148
16405955-3	2006	Drinking-WTRs can be obtained free-of-charge from drinking-water treatment plants, and they have been successfully used to reduce soluble phosphorus (P) concentrations in poorly P-sorbing soils.	Water	59-64	WTRS	Homo sapiens	9-13
16633891-9	2006	Rolipram, a phosphodiesterase IV inhibitor, increased CREB DNA binding activity and decreased toxicity, whereas TNFalpha, increased NF-kappaB DNA-binding activity and increased neurotoxicity to both glutamate and H(2)O(2).	Water	213-218	tumor necrosis factor	Homo sapiens	112-120
16714226-5	2006	E. purpurea extracted in a solvent mixture of 95:5 ethanol/water dose-dependently inhibited IL-2 production.	Water	59-64	interleukin 2	Homo sapiens	92-96
16500722-6	2006	An example for a process depending on compartmentalised cAMP/PKA signalling is the arginine-vasopressin (AVP)-mediated water reabsorption in renal collecting duct principal cells.	Water	119-124	arginine vasopressin	Homo sapiens	83-103
16500722-6	2006	An example for a process depending on compartmentalised cAMP/PKA signalling is the arginine-vasopressin (AVP)-mediated water reabsorption in renal collecting duct principal cells.	Water	119-124	arginine vasopressin	Homo sapiens	105-108
16781456-4	2006	PTP1B glutathionylation was dependent on H(2)O(2) as the presence of catalase at the time of ADP stimulation inhibited the formation of the conjugate.	Water	41-46	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	0-5
16781456-4	2006	PTP1B glutathionylation was dependent on H(2)O(2) as the presence of catalase at the time of ADP stimulation inhibited the formation of the conjugate.	Water	41-46	catalase	Rattus norvegicus	69-77
16682607-3	2006	The water channel aquaporin-1 transports low molecular weight gases in addition to water and is expressed in cells that produce or are the targets of NO.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	18-29
16682607-5	2006	In cells expressing aquaporin-1, NO permeability correlated with water permeability.	Water	65-70	aquaporin 1 (Colton blood group)	Homo sapiens	20-31
16417942-7	2006	The other two groups; control and diabetic animals, only received tap water.	Water	70-75	nuclear RNA export factor 1	Rattus norvegicus	66-69
16856737-3	2006	The model predictions are compared with the previously reported experimental PCB concentrations in the bulk water phase and in SPMDs.	Water	108-113	pyruvate carboxylase	Homo sapiens	77-80
16714226-7	2006	Simultaneous measurement of secreted IL-2 by ELISA and cell viability by the XTT assay showed that the 95:5 ethanol/water extract of E. purpurea was both IL-2 suppressive and cytotoxic at 50 and 100 microg/mL.	Water	116-121	interleukin 2	Homo sapiens	154-158
16786151-0	2006	Comano"s (Trentino) thermal water interferes with the expression and secretion of vascular endothelial growth factor-A protein isoforms by cultured human psoriatic keratinocytes: a potential mechanism of its anti-psoriatic action.	Water	28-33	vascular endothelial growth factor A	Homo sapiens	82-118
16443618-0	2006	Fibronectin immobilization using water-soluble carbodiimide on poly-L-lactic acid for enhancing initial fibroblast attachment.	Water	33-38	fibronectin 1	Homo sapiens	0-11
16443618-5	2006	Fibronectin is immobilized onto the hydrolyzed PLA surface through a condensation reaction between the carboxylic acid groups on the hydrolyzed PLA surface and the amino groups of fibronectin using water-soluble carbodiimide.	Water	198-203	fibronectin 1	Homo sapiens	0-11
16443618-5	2006	Fibronectin is immobilized onto the hydrolyzed PLA surface through a condensation reaction between the carboxylic acid groups on the hydrolyzed PLA surface and the amino groups of fibronectin using water-soluble carbodiimide.	Water	198-203	fibronectin 1	Homo sapiens	180-191
16713603-3	2006	In the present study, the effects of a potent water-soluble antioxidant, salvianolic acid B (SalB), derived from a Chinese herb, Salvia miltiorrhiza, on the expression of MMP-2 by TNF-alpha-treated human aortic smooth muscle cells (HASMCs) were investigated.	Water	46-51	tumor necrosis factor	Homo sapiens	180-189
16915825-9	2006	Pesticide-specific losses occurred on the C18 disks in this study, underlining the importance of temperature and time interval when water is extracted at remote field locations and the SPE disks containing the extracted pesticides are transported or shipped to a laboratory for elution and analysis.	Water	132-137	Bardet-Biedl syndrome 9	Homo sapiens	42-45
16611841-9	2006	When the rats were water deprived for 2 days the presynaptic response to GAL was unaltered; however, the postsynaptic decrease in input resistance and hyperpolarization was increased, an effect consistent with a previously described increase in GAL1 receptor expression in dehydration.	Water	19-24	galanin and GMAP prepropeptide	Rattus norvegicus	73-76
16611841-9	2006	When the rats were water deprived for 2 days the presynaptic response to GAL was unaltered; however, the postsynaptic decrease in input resistance and hyperpolarization was increased, an effect consistent with a previously described increase in GAL1 receptor expression in dehydration.	Water	19-24	galectin 1	Rattus norvegicus	245-249
16886094-2	2006	Previous experiments show that addition of only 0.12 PPM copper (one-tenth the Environmental Protection Agency Human consumption limits) to distilled water was sufficient to precipitate the accumulation of Abeta in the brains of cholesterol-fed rabbits (1).	Water	150-155	amyloid beta precursor protein	Homo sapiens	206-211
16889063-5	2006	On a base-deactivated C18 column good separation and excellent peak shape of the analytes are achieved in short time by gradient elution with water and acetonitrile.	Water	142-147	Bardet-Biedl syndrome 9	Homo sapiens	22-25
16716756-7	2006	The occurrence of both these apparently opposite effects on the renal water and sodium handling suggests a complex role of PPARgamma in the kidney that is likely related to the metabolic state.	Water	70-75	peroxisome proliferator activated receptor gamma	Homo sapiens	123-132
16800599-5	2006	Unsaturation in the C18 urea surfactants lowers the melting point and promotes an inverse hexagonal phase, in oleyl urea-water and linoleyl urea-water systems, which is thermodynamically stable in excess water.	Water	121-126	Bardet-Biedl syndrome 9	Homo sapiens	20-23
16800527-0	2006	Polymorphic behavior in protein-surfactant mixtures: the water-bovine serum albumin-sodium taurodeoxycholate system.	Water	57-62	albumin	Homo sapiens	70-83
16821953-3	2006	We report molecular dynamics simulations of three globular proteins: ubiquitin, apo-calbindin D(9K), and the C-terminal SH2 domain of phospholipase C-gamma1 in explicit water.	Water	169-174	S100 calcium binding protein G	Homo sapiens	84-98
16821953-3	2006	We report molecular dynamics simulations of three globular proteins: ubiquitin, apo-calbindin D(9K), and the C-terminal SH2 domain of phospholipase C-gamma1 in explicit water.	Water	169-174	phospholipase C gamma 1	Homo sapiens	134-156
16821954-3	2006	We report molecular dynamics (MD) simulations of three protein-water systems (ubiquitin, apo-calbindin D(9K), and the C-terminal SH2 domain of phospholipase C-gamma1), from which we compute the dielectric properties of the solutions.	Water	63-68	phospholipase C gamma 1	Homo sapiens	143-165
16621806-0	2006	NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water.	Water	80-85	gastric inhibitory polypeptide	Homo sapiens	32-76
16621806-4	2006	In this study, we present the solution structure of GIP in water determined by NMR spectroscopy.	Water	59-64	gastric inhibitory polypeptide	Homo sapiens	52-55
16413028-2	2006	The quartz crystal oscillator was attached horizontally on the DHP and DPPC monolayers that were formed on the water surface.	Water	111-116	dihydropyrimidinase	Homo sapiens	63-66
16643970-7	2006	HSD produced an increase in water intake (drinking activity and volume consumed) in both groups with no difference in the percentage increase or the light/dark drinking rhythm.	Water	28-33	histidine ammonia lyase	Mus musculus	0-3
16596641-4	2006	Here, the flexibility of p16(INK4a) at room temperature and its unfolding mechanism at high temperature have been investigated by multiple molecular dynamics runs in explicit water for a total simulation time of 0.65 micros.	Water	175-180	cyclin dependent kinase inhibitor 2A	Homo sapiens	25-28
16596641-4	2006	Here, the flexibility of p16(INK4a) at room temperature and its unfolding mechanism at high temperature have been investigated by multiple molecular dynamics runs in explicit water for a total simulation time of 0.65 micros.	Water	175-180	cyclin dependent kinase inhibitor 2A	Homo sapiens	29-34
16800599-5	2006	Unsaturation in the C18 urea surfactants lowers the melting point and promotes an inverse hexagonal phase, in oleyl urea-water and linoleyl urea-water systems, which is thermodynamically stable in excess water.	Water	145-150	Bardet-Biedl syndrome 9	Homo sapiens	20-23
16800599-5	2006	Unsaturation in the C18 urea surfactants lowers the melting point and promotes an inverse hexagonal phase, in oleyl urea-water and linoleyl urea-water systems, which is thermodynamically stable in excess water.	Water	145-150	Bardet-Biedl syndrome 9	Homo sapiens	20-23
16406579-7	2006	These detection levels corresponded closely to expected trace metal contents of mouse chow and tap water.	Water	99-104	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	95-98
16771341-0	2006	Effective interaction potentials for alkali and alkaline earth metal ions in SPC/E water and polarization model of hydrated ions.	Water	83-88	proline rich protein gene cluster	Homo sapiens	77-80
16771341-3	2006	B, 2006, 110, 10878), effective ion-ion potentials in SPC/E water were obtained for Me-Me, Me-Cl-, and Cl(-)-Cl- pairs, where Me is Li+, Na+, K+, Mg2+, Ca2+, Sr2+, and Ba2+ cations.	Water	60-65	proline rich protein gene cluster	Homo sapiens	54-57
16396942-12	2006	AVP deficiency significantly increased urine output and solute-free water clearance and decreased urine osmolality.	Water	68-73	arginine vasopressin	Rattus norvegicus	0-3
16733497-7	2006	In addition to regulating cardiovascular function, apelin inhibits water intake and vasopressin production.	Water	67-72	apelin	Homo sapiens	51-57
16786909-1	2006	Increased arginine vasopressin (AVP) secretion in heart failure may lead to vasoconstriction, left ventricular remodeling, and water retention-actions that promote afterload, preload, and hyponatremia and thereby cause disease progression.	Water	127-132	arginine vasopressin	Homo sapiens	19-30
16510697-1	2006	In this study, a cationic water-soluble ceramide analog L-threo-C6-pyridinium-ceramide-bromide (L-t-C6-Pyr-Cer), which exhibits high solubility and bioavailability, inhibited the growth of various human head and neck squamous cell carcinoma (HNSCC) cell lines at low IC50 concentrations, independent of their p53 status.	Water	26-31	tumor protein p53	Homo sapiens	309-312
16690170-1	2006	Fully deprotected phosphonamidate dipeptides, predicted as effective inhibitors of cytosolic leucine aminopeptidase, showed unexpected instability in water solution at pH below 12.	Water	150-155	carboxypeptidase Q	Homo sapiens	101-115
16741039-1	2006	Adenosine triphosphate (ATP) and endothelin (ET)-1 inhibit vasopressin-stimulated water reabsorption in the inner medullary collecting duct (IMCD).	Water	82-87	endothelin 1	Rattus norvegicus	33-50
16741039-2	2006	Because both ATP and ET-1 are released by the IMCD and can act in an autocrine manner to regulate IMCD water transport, we sought to determine whether these factors can modulate the other"s production.	Water	103-108	endothelin 1	Rattus norvegicus	21-25
16921951-8	2006	The organic matter and various ion in tap water will decrease the degradation rate.	Water	42-47	SEC14 like lipid binding 2	Homo sapiens	38-41
16440326-3	2006	In the present study, the effects of a water-soluble antioxidant, salvianolic acid B (Sal B), derived from a Chinese herb, on the expression of cyclooxygenase (COX) in lipopolysaccharide (LPS)-treated human aortic smooth muscle cells (HASMCs) and in the aortas of cholesterol-fed apoE deficient mice were investigated.	Water	39-44	apolipoprotein E	Homo sapiens	280-284
16545962-8	2006	In this work, inactive Rab11b crystallized as a monomer showing a flexible Switch I and a magnesium ion which is coordinated by four water molecules, the phosphate beta of GDP (beta-P) and the invariant S25.	Water	133-138	RAB11B, member RAS oncogene family	Homo sapiens	23-29
16496175-4	2006	Water permeability assays and lectin staining showed that a mutation in the DPY-14 collagen results in defects in the channels of the amphids, which are a class of ciliated neuron, while the amphids appear morphologically normal by dye filling methods.	Water	0-5	Col_cuticle_N domain-containing protein	Caenorhabditis elegans	76-82
17048623-3	2006	A mixture of water-acetonitrile-sodium dodecyl sulfate-phosphorous acid (650:350:5:1) was used as the mobile phase at flow rate of 1.5 mL x min(-1).	Water	13-18	CD59 molecule (CD59 blood group)	Homo sapiens	140-146
16481069-6	2006	The robust increase in vesicular glutamate transporter-2 mRNA and immunoreactivity after salt loading suggests that the cellular levels of vesicular glutamate transporter-2 in vasopressin neurons are regulated by alterations in water-electrolyte balance.	Water	228-233	arginine vasopressin	Rattus norvegicus	176-187
16906833-4	2006	Starting with very dense systems and decreasing the density, both mobilities first increase, reach a maximum, then decrease, reach a minimum, and finally increase; this behavior is similar to the behavior of SPC/E (Simple Point Charge-Extended) water.	Water	245-250	proline rich protein gene cluster	Homo sapiens	208-211
18232127-2	2006	Elevated vasopressin levels in heart failure cause myocardial fibrosis, hypertrophy and vasoconstriction by activating the V1a receptors, as well as water retention and hyponatremia by activating V2 receptors.	Water	149-154	arginine vasopressin	Homo sapiens	9-20
18232127-6	2006	The predominant action of vasopressin receptor antagonists is water excretion, without depletion of other electrolytes, and less neurohormonal stimulation compared with loop diuretics.	Water	62-67	arginine vasopressin	Homo sapiens	26-37
16256193-1	2006	We used the in vitro dually perfused human placental lobule to test the hypothesis that known vasoconstrictors of the fetal placental circulation, angiotensin II and the thromboxane mimetic U46619 could induce fetomaternal water transfer.	Water	223-228	angiotensinogen	Homo sapiens	147-161
16551622-6	2006	TEA inhibition was lost upon a Tyr to Phe amino acid switch in the external water pore of AQP1/AQP2/AQP4, whereas the water permeability of AQP3 and AQP5, which lack a corresponding Tyr, was not blocked by TEA.	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	90-94
16706476-5	2006	At higher water contents, however, the denatured lysozyme can absorb a greater amount of water than the native protein due to the larger number of available sorption sites.	Water	10-15	lysozyme	Homo sapiens	49-57
16706476-5	2006	At higher water contents, however, the denatured lysozyme can absorb a greater amount of water than the native protein due to the larger number of available sorption sites.	Water	89-94	lysozyme	Homo sapiens	49-57
16706476-7	2006	Despite the unfolded structure, the denatured lysozyme binds less water than does the native lysozyme in the desorption experiments at water contents up to 34 wt %.	Water	66-71	lysozyme	Homo sapiens	46-54
16706476-7	2006	Despite the unfolded structure, the denatured lysozyme binds less water than does the native lysozyme in the desorption experiments at water contents up to 34 wt %.	Water	135-140	lysozyme	Homo sapiens	46-54
16706476-7	2006	Despite the unfolded structure, the denatured lysozyme binds less water than does the native lysozyme in the desorption experiments at water contents up to 34 wt %.	Water	135-140	lysozyme	Homo sapiens	93-101
16551622-7	2006	Consistent with experimental data, multi-nanosecond molecular dynamics simulations showed one stable binding site for TEA, but not tetramethyl (TMA), in AQP1, resulting in a nearly 50% water permeability inhibition, which was reduced in AQP1-Y186F due to effects on the TEA inhibitory binding region.	Water	185-190	aquaporin 1 (Colton blood group)	Homo sapiens	153-157
16500986-1	2006	Detection of a significant transmembrane water flux immediately after cotransporter stimulation is the experimental basis for the controversial hypothesis of secondary active water transport involving a proposed stoichiometry for the human Na(+)/glucose cotransporter (SGLT1) of two Na(+), one glucose, and 264 water molecules.	Water	175-180	solute carrier family 5 member 1	Homo sapiens	269-274
16674041-4	2006	In the A-2 hydrolysis, two water molecules are involved in the rate-determining step.	Water	27-32	ATPase H+ transporting V0 subunit a2	Homo sapiens	7-10
16500986-1	2006	Detection of a significant transmembrane water flux immediately after cotransporter stimulation is the experimental basis for the controversial hypothesis of secondary active water transport involving a proposed stoichiometry for the human Na(+)/glucose cotransporter (SGLT1) of two Na(+), one glucose, and 264 water molecules.	Water	41-46	solute carrier family 5 member 1	Homo sapiens	269-274
16500986-1	2006	Detection of a significant transmembrane water flux immediately after cotransporter stimulation is the experimental basis for the controversial hypothesis of secondary active water transport involving a proposed stoichiometry for the human Na(+)/glucose cotransporter (SGLT1) of two Na(+), one glucose, and 264 water molecules.	Water	175-180	solute carrier family 5 member 1	Homo sapiens	269-274
16543266-1	2006	Studies from our laboratory and others show that oestrogen reduces angiotensin II (Ang II)-induced water intake by ovariectomized rats.	Water	99-104	angiotensinogen	Rattus norvegicus	67-81
16543266-1	2006	Studies from our laboratory and others show that oestrogen reduces angiotensin II (Ang II)-induced water intake by ovariectomized rats.	Water	99-104	angiotensinogen	Rattus norvegicus	83-89
16543266-8	2006	Thus, we propose that weight loss decreases Ang II-elicited water intake in the female rat by down-regulating the expression of the AT1 receptor.	Water	60-65	angiotensinogen	Rattus norvegicus	44-50
15996719-2	2006	This residential area (the CSL site) is representative of more than 70 such areas in southern New Jersey where about 600 domestic wells, sampled previously by State and county agencies, yielded water containing Hg at concentrations that exceed the MCL.	Water	194-199	chorionic somatomammotropin hormone like 1	Homo sapiens	27-30
15996719-5	2006	At the CSL site, concentrations of Hg were substantially lower (although still exceeding the MCL in some cases) in filtered water samples than in the unfiltered water samples collected previously from the same wells.	Water	124-129	chorionic somatomammotropin hormone like 1	Homo sapiens	7-10
16352742-9	2006	The vasopressin V(2) receptor antagonist OPC-31260 increased percent water excretion and urinary output and reduced U(osm) compared with vehicle-treated GD rats.	Water	69-74	arginine vasopressin receptor 2	Rattus norvegicus	4-29
16633692-6	2006	In particular, we investigated the dissociation path of one water molecule from the first hydration shell of Co(II) with CPMD.	Water	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
16689581-5	2006	The radial distributions from Monte Carlo simulations show the best agreement with the results for ions in SPC/E water for the expansion up to the charge-hexadecapole term.	Water	113-118	proline rich protein gene cluster	Homo sapiens	107-110
16636271-0	2006	Apolipoprotein B is conformationally flexible but anchored at a triolein/water interface: a possible model for lipoprotein surfaces.	Water	73-78	apolipoprotein B	Homo sapiens	0-16
16636271-4	2006	We showed that two consensus AbetaS peptides of apoB bound strongly to hydrophobic interfaces [triolein/water (TO/W) and dodecane/water], were elastic, and were not pushed off the interface when the surface was compressed.	Water	104-109	apolipoprotein B	Homo sapiens	48-52
16636271-4	2006	We showed that two consensus AbetaS peptides of apoB bound strongly to hydrophobic interfaces [triolein/water (TO/W) and dodecane/water], were elastic, and were not pushed off the interface when the surface was compressed.	Water	130-135	apolipoprotein B	Homo sapiens	48-52
16464581-0	2006	The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor.	Water	47-52	adenosine A3 receptor	Homo sapiens	83-104
16473902-6	2006	This grabbing motion resulted in smooth and stepwise exchange in coordination partners of Ca2+ from water oxygen to atoms in the calmodulin loop.	Water	100-105	calmodulin 1	Homo sapiens	129-139
16892389-6	2006	These results confirm the importance of the structural water molecule in the active site and may constitute the basis for the design of transition-state-based PARP inhibitors.	Water	55-60	poly(ADP-ribose) polymerase 1	Homo sapiens	159-163
16281046-2	2006	In co-crystals with PDE5, one of the rings of vardenafil or sildenafil interacts with Tyr(612), a catalytic site AA, via (1) a hydrogen bond with a water molecule and (2) hydrophobic bonds.	Water	148-153	phosphodiesterase 5A	Homo sapiens	20-24
17552085-3	2006	AVP causes water retention by interacting with V2 receptors in the renal collecting duct, leading to dilutional hyponatremia and increased ventricular preload.	Water	11-16	arginine vasopressin	Homo sapiens	0-3
17552085-7	2006	Unlike diuretics, which increase urine volume and electrolyte excretion, AVP antagonists of these types produce an aquaresis characterized by an increase in free water clearance concomitant with sparing of electrolytes.	Water	162-167	arginine vasopressin	Homo sapiens	73-76
16719114-5	2006	However, the addition of constituents (SO4(2-), SO3(2-), HS-, CI-, HCO3-, OH-, and humic acid) on the order of representative concentrations for drinking water decreased the NO3- reduction rate.	Water	154-159	NBL1, DAN family BMP antagonist	Homo sapiens	174-177
16534779-0	2006	Localization of aquaporin-1 water channel in glial cells of the human peripheral nervous system.	Water	28-33	aquaporin 1 (Colton blood group)	Homo sapiens	16-27
16534779-2	2006	AQP1, AQP4, and AQP9 have been identified in the central nervous system and demonstrated or proposed to play important roles in brain water homeostasis.	Water	134-139	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
16534779-2	2006	AQP1, AQP4, and AQP9 have been identified in the central nervous system and demonstrated or proposed to play important roles in brain water homeostasis.	Water	134-139	aquaporin 9	Homo sapiens	16-20
16534779-4	2006	Here we report that the AQP1 water channel is specifically localized to glial cells of the peripheral nervous system by immunohistochemistry, RT-PCR, and immunoblotting.	Water	29-34	aquaporin 1 (Colton blood group)	Homo sapiens	24-28
16219341-4	2006	Differences between the Aire and the Ouse were found, reflecting their different water quality regime.	Water	81-86	autoimmune regulator	Homo sapiens	24-28
16339345-8	2006	Attenuation of brain water content with 7.5% HS treatment coincides with attenuated serum AVP levels, and we speculate that this may represent one additional mechanism by which osmotherapy attenuates edema associated with ischemic stroke.	Water	21-26	arginine vasopressin	Rattus norvegicus	90-93
16679903-9	2006	The effective contact coefficient was significantly greater in conventional wounds than bFGF-treated wounds (14.6 +/- 1.68 % vs 8.7 +/- 2.82 %; conventional vs bFGF, P &lt; .01) and bFGF-treated wounds demonstrated significantly less transepidermal water loss values than conventional treatment (8.3 +/- 1.90 g/m/h vs 5.7 +/- 1.85 g/m/hr; conventional vs bFGF, P &lt; .01).	Water	249-254	fibroblast growth factor 2	Homo sapiens	88-92
16806956-8	2006	Using Fe(III)-immobilized metal chromatography to determine the apparent phosphorylation status of the enzyme in vivo, we showed that soluble SS was largely dephosphorylated in fruits fed EGTA or staurosporine, compared to fruits fed water or sucrose.	Water	234-239	sucrose synthase	Solanum lycopersicum	142-144
16672351-7	2006	Microinjection of C-mos dsRNA has resulted in 70% reduction of C-mos transcript after maturation compared to the water-injected and uninjected controls (P&lt;0.01).	Water	113-118	MOS proto-oncogene, serine/threonine kinase	Bos taurus	18-23
16672351-10	2006	From oocytes injected with C-mos dsRNA, 60% showed the extrusion of the first polar body compared to 50% in water-injected and 44% in uninjected controls.	Water	108-113	MOS proto-oncogene, serine/threonine kinase	Bos taurus	27-32
16640603-3	2006	In this communication we present evidence that DPE2 acts on the recently identified cytosolic water-soluble heteroglycans (SHG) as does the cytosolic phosphorylase (EC 2.4.1.1) isoform.	Water	94-99	disproportionating enzyme 2	Arabidopsis thaliana	47-51
16755884-0	2006	[Effects of prostate water pellets on the serum levels of IL-6 and TNF-alpha in rats with chronic bacterial prostatitis].	Water	21-26	interleukin 6	Rattus norvegicus	58-62
16574474-6	2006	The thermal behaviour of these chelates shows that the hydrated complexes losses water molecules of hydration in the first step followed immediately by decomposition of the coordinated water, anions and ligands (L1 and L2) in the subsequent steps.	Water	81-86	L1 cell adhesion molecule	Homo sapiens	212-221
16574474-6	2006	The thermal behaviour of these chelates shows that the hydrated complexes losses water molecules of hydration in the first step followed immediately by decomposition of the coordinated water, anions and ligands (L1 and L2) in the subsequent steps.	Water	185-190	L1 cell adhesion molecule	Homo sapiens	212-221
16713495-2	2006	Patients with hereditary NDI bearing mutations in AVPR2, the gene coding for the arginine vasopressin 2 receptor, or in AQP2, the gene coding for the vasopressin-sensitive water channel, have a pure NDI phenotype with loss of water, but normal conservation of sodium, potassium, chloride, and calcium.	Water	172-177	arginine vasopressin	Homo sapiens	150-161
16755884-0	2006	[Effects of prostate water pellets on the serum levels of IL-6 and TNF-alpha in rats with chronic bacterial prostatitis].	Water	21-26	tumor necrosis factor	Rattus norvegicus	67-76
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	Water	303-306	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	Water	303-306	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16610880-2	2006	The 3PEPS results show a multiexponential behavior with two subpicosecond components that are similar in bulk and interfacial water, while a third component of several picoseconds is significantly lengthened at the interface.	Water	126-131	leucine aminopeptidase 3	Homo sapiens	5-9
16610785-0	2006	Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking.	Water	102-107	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	51-70
16610785-7	2006	Finally, the optimal docking strategy in terms of virtual screening accuracy, GOLD-Chemscore with the consideration of active-site water (60% of known substrates recovered in the top 5% of the ranked drug-like database), was verified experimentally; it was successfully used to identify high-affinity CYP2D6 ligands among a larger proprietary database.	Water	131-136	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	301-307
16600576-10	2006	Under water deficient conditions, biochemical changes include protecting enzyme system, for instance superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD).	Water	6-11	superoxide dismutase 1	Homo sapiens	101-121
16600576-10	2006	Under water deficient conditions, biochemical changes include protecting enzyme system, for instance superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD).	Water	6-11	superoxide dismutase 1	Homo sapiens	123-126
16600576-10	2006	Under water deficient conditions, biochemical changes include protecting enzyme system, for instance superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD).	Water	6-11	catalase	Homo sapiens	129-137
16600576-10	2006	Under water deficient conditions, biochemical changes include protecting enzyme system, for instance superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD).	Water	6-11	catalase	Homo sapiens	139-142
16599429-7	2006	In suspensions of human serum albumin (HSA) in water, remarkable enhancement of the fluorescence intensity and lifetime is observed for m-ANCN and its N-alkylated derivatives, demonstrating that m-ANCNs can be a candidate for novel fluorescent probe with small molecular size.	Water	47-52	albumin	Homo sapiens	24-37
16580609-5	2006	In these families, mutations have been identified in the aquaporin-2 gene (AQP2) (OMIM 107777), which codes for the vasopressin-sensitive water channel.	Water	138-143	arginine vasopressin	Homo sapiens	116-127
16449382-1	2006	The inner medullary collecting duct (IMCD) is an important site of vasopressin-regulated water and urea transport.	Water	89-94	arginine vasopressin	Rattus norvegicus	67-78
16505984-9	2006	This simple method was applied to the simultaneous determination of HQ and CAT in a household tap water sample and it exhibited high selectivity.	Water	98-103	catalase	Homo sapiens	75-78
16613635-2	2006	Attenuated total reflection Fourier transform infrared spectroscopy (ATR/FT-IR) was used to monitor the in situ water diffusion process in these systems.	Water	112-117	ATR serine/threonine kinase	Homo sapiens	69-72
16377069-2	2006	Experimental data from literature regarding the preferential binding parameter were used to calculate the excesses (or deficits) of water and PEG in the vicinity of beta-lactoglobulin, bovine serum albumin, lysozyme, chymotrypsinogen and ribonuclease A.	Water	132-137	albumin	Homo sapiens	192-205
16603260-1	2006	The green fluorescent protein (GFP) of the jellyfish, Aeqorea victoria, was used as an autofluorescent tag to track the trafficking of aquaporin 5 (AQP5), an exocrine gland-type water channel.	Water	178-183	aquaporin 5	Canis lupus familiaris	135-146
16563128-1	2006	BACKGROUND INFORMATION: Aquaporin 2 (AQP2) plays an important, VP (vasopressin)-regulated role in water reabsorption by the kidney.	Water	98-103	arginine vasopressin	Homo sapiens	63-65
16563128-1	2006	BACKGROUND INFORMATION: Aquaporin 2 (AQP2) plays an important, VP (vasopressin)-regulated role in water reabsorption by the kidney.	Water	98-103	arginine vasopressin	Homo sapiens	67-78
16413781-0	2006	Investigation of mechanism-based thrombin inhibitors: Implications of a highly conserved water molecule for the binding of coumarins within the S pocket.	Water	89-94	coagulation factor II, thrombin	Homo sapiens	33-41
16595900-2	2006	Hop water extract (HWE) and XAD-4 50% methanol fraction of HWE (MFH) inhibited histamine release from rat mast cells induced by compound 48/80 at concentrations of 100 and 10 mug/ml, respectively.	Water	4-9	stress-induced phosphoprotein 1	Rattus norvegicus	0-3
16603260-1	2006	The green fluorescent protein (GFP) of the jellyfish, Aeqorea victoria, was used as an autofluorescent tag to track the trafficking of aquaporin 5 (AQP5), an exocrine gland-type water channel.	Water	178-183	aquaporin 5	Canis lupus familiaris	148-152
16565390-4	2006	EAU was also induced in wild-type B6 (WT) and BLT1-deficient (BLT1-/-) mice by reciprocal transfer of the T cells from B6 to BLT1-deficient mice and vise versa.	Water	0-3	leukotriene B4 receptor 1	Mus musculus	46-50
16749244-8	2006	For example, the flow rate of water through AQP1 is an extraordinary three billion water molecules per second per aquaporin channel, while a relative trickle of water crosses the hydrophobic lipid bilayer of cell membranes devoid of AQPs.	Water	30-35	aquaporin 1 (Colton blood group)	Homo sapiens	44-48
16749244-8	2006	For example, the flow rate of water through AQP1 is an extraordinary three billion water molecules per second per aquaporin channel, while a relative trickle of water crosses the hydrophobic lipid bilayer of cell membranes devoid of AQPs.	Water	83-88	aquaporin 1 (Colton blood group)	Homo sapiens	44-48
16749244-8	2006	For example, the flow rate of water through AQP1 is an extraordinary three billion water molecules per second per aquaporin channel, while a relative trickle of water crosses the hydrophobic lipid bilayer of cell membranes devoid of AQPs.	Water	83-88	aquaporin 1 (Colton blood group)	Homo sapiens	44-48
18095114-11	2006	The fact that AQP-1 was highly expressed at the dural attachment and invading front of meningioma may indicate that dural invasion of the meningioma may be facilitated by AQP-1-induced water flow and neovascularization.	Water	185-190	aquaporin 1 (Colton blood group)	Homo sapiens	14-19
18095114-11	2006	The fact that AQP-1 was highly expressed at the dural attachment and invading front of meningioma may indicate that dural invasion of the meningioma may be facilitated by AQP-1-induced water flow and neovascularization.	Water	185-190	aquaporin 1 (Colton blood group)	Homo sapiens	171-176
16542375-5	2006	When mycobacterial glycolipids were injected as water-in-oil-in-water emulsion into mice via the tail vein, development of pulmonary granuloma in response to glycolipids were related closely to their TNF-inducing activity and TDM exhibited the strongest activity.	Water	48-53	tumor necrosis factor	Mus musculus	200-203
16565393-1	2006	PURPOSE: Aquaporin 0 (AQP0), the most abundant membrane protein in the lens, is a water-permeable channel, has a role in fiber cell adhesion, and is essential for fiber cell structure and organization.	Water	82-87	major intrinsic protein of lens fiber	Homo sapiens	9-20
16565393-1	2006	PURPOSE: Aquaporin 0 (AQP0), the most abundant membrane protein in the lens, is a water-permeable channel, has a role in fiber cell adhesion, and is essential for fiber cell structure and organization.	Water	82-87	major intrinsic protein of lens fiber	Homo sapiens	22-26
16565393-9	2006	CONCLUSIONS: These studies suggest a novel interaction between an aquaporin water channel and intermediate filaments, an interaction through which AQP0 may maintain lens fiber cell shape and organization.	Water	76-81	major intrinsic protein of lens fiber	Homo sapiens	147-151
16650887-2	2006	We have show previously the central involvement of angiotensin II (ANGII) in water intake.	Water	77-82	angiotensinogen	Homo sapiens	51-65
16789425-4	2006	This is evidenced by linear correlations between inhibition of CYP3A4 and the octanol-water partition coefficient (P value) when expressed logarithmically (ie., log P).	Water	86-91	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	63-69
16531985-12	2006	Endogenous UII appears to contribute to the regulation of GFR and renal sodium and water handling in the rat.	Water	83-88	urotensin 2	Rattus norvegicus	11-14
16375968-2	2006	Central administration of IL-1beta at the doses of 4 and 8 ng reduced water intake in all three conditions studied.	Water	70-75	interleukin 1 beta	Rattus norvegicus	26-34
16375968-0	2006	Inhibition of water intake by the central administration of IL-1beta in rats: role of the central opioid system.	Water	14-19	interleukin 1 beta	Rattus norvegicus	60-68
16375968-1	2006	In the present study we investigated, the effect of third ventricle injections of IL-1beta on water intake, in rats, induced by three different physiological stimuli: dehydration induced by water deprivation, hypernatremia associated with hyperosmolarity induced by intragastric salt load, and hypovolemia produced by subcutaneous polytethyleneglycol administration.	Water	94-99	interleukin 1 beta	Rattus norvegicus	82-90
16650887-9	2006	The results described in this paper provide evidence that calcium channels play important roles in the ANGII-induced behavioral water intake.	Water	128-133	angiotensinogen	Homo sapiens	103-108
16650887-2	2006	We have show previously the central involvement of angiotensin II (ANGII) in water intake.	Water	77-82	angiotensinogen	Homo sapiens	67-72
16194601-1	2006	BACKGROUND: Hot tub lung is an emerging lung disorder associated with exposure to Mycobacterium avium complex organisms contaminating hot tub water.	Water	142-147	TUB bipartite transcription factor	Homo sapiens	16-19
16194601-1	2006	BACKGROUND: Hot tub lung is an emerging lung disorder associated with exposure to Mycobacterium avium complex organisms contaminating hot tub water.	Water	142-147	TUB bipartite transcription factor	Homo sapiens	138-141
16480683-3	2006	In the present work, the reaction of cytochrome c with GSH in water was characterized using mass spectrometry.	Water	62-67	cytochrome c, somatic	Homo sapiens	37-49
16711807-5	2006	Molecular dynamics simulations of extended simple point charge (SPC/E) water show a large vortexlike structure of the dipole field at ambient conditions surviving over [J. Higo, Proc.	Water	71-76	proline rich protein gene cluster	Homo sapiens	64-67
16711807-11	2006	Motivated by these recent results, we study the water dipole reorientation using molecular dynamics simulations of the SPC/E model in bulk water for temperatures ranging from ambient 300 K down to the deep supercooled region of the phase diagram at 210 K. First, we calculate the dipole autocorrelation function and find that our simulations are well described by a stretched exponential decay, from which we calculate the orientational autocorrelation time t(alpha).	Water	48-53	proline rich protein gene cluster	Homo sapiens	119-122
16711807-11	2006	Motivated by these recent results, we study the water dipole reorientation using molecular dynamics simulations of the SPC/E model in bulk water for temperatures ranging from ambient 300 K down to the deep supercooled region of the phase diagram at 210 K. First, we calculate the dipole autocorrelation function and find that our simulations are well described by a stretched exponential decay, from which we calculate the orientational autocorrelation time t(alpha).	Water	139-144	proline rich protein gene cluster	Homo sapiens	119-122
16480680-0	2006	Acetazolamide inhibits osmotic water permeability by interaction with aquaporin-1.	Water	31-36	aquaporin 1 (Colton blood group)	Homo sapiens	70-81
16548513-2	2006	The crystal structure of hGSTM1a-1a with bound glutathione (GSH) was solved to 1.9 A resolution, and site-directed mutagenesis supports the conclusion that a proton transfer occurs in which bound water at the catalytic site acts as a primary proton acceptor from the GSH thiol group to transfer the proton to His107.	Water	196-201	glutathione S-transferase mu 1	Homo sapiens	25-35
16480680-6	2006	Acetazolamide, at concentrations of 1 and 10muM, inhibited the osmotic water permeability in HEK293 cells transfected with pEGFP/AQP1.	Water	71-76	latexin	Homo sapiens	44-47
16480680-6	2006	Acetazolamide, at concentrations of 1 and 10muM, inhibited the osmotic water permeability in HEK293 cells transfected with pEGFP/AQP1.	Water	71-76	aquaporin 1 (Colton blood group)	Homo sapiens	129-133
16480680-10	2006	This study demonstrated that acetazolamide inhibited osmotic water permeability through interaction with AQP1.	Water	61-66	aquaporin 1 (Colton blood group)	Homo sapiens	105-109
16506790-1	2006	The highly basic heme enzyme myeloperoxidase (MPO), which is released by activated phagocytes, catalyzes the production of the potent oxidant hypochlorite (HOCl) from H(2)O(2) and chloride ions (Cl(-)).	Water	167-172	myeloperoxidase	Homo sapiens	29-44
16519465-0	2006	Dilational viscoelasticity of PEO-PPO-PEO triblock copolymer films at the air-water interface in the range of high surface pressures.	Water	78-83	protoporphyrinogen oxidase	Homo sapiens	34-37
16506790-1	2006	The highly basic heme enzyme myeloperoxidase (MPO), which is released by activated phagocytes, catalyzes the production of the potent oxidant hypochlorite (HOCl) from H(2)O(2) and chloride ions (Cl(-)).	Water	167-172	myeloperoxidase	Homo sapiens	46-49
16499347-0	2006	General route to three-dimensional framework uranyl transition metal phosphates with atypical structural motifs: the case examples of Cs2{(UO2)4[Co(H2O)2]2(HPO4)(PO4)4} and Cs3+x[(UO2)3CuH4-x(PO4)5].H2O.	Water	148-151	chorionic somatomammotropin hormone 2	Homo sapiens	134-137
16499347-1	2006	The reaction of UO2(NO3)2.6H2O with Co or Cu metal, phosphoric acid, and CsCl under mild hydrothermal conditions results in the formation of Cs2{(UO2)4[Co(H2O)2(HPO4)(PO4)4} (1) or Cs(3+x)[(UO2)3CuH(4-x)(PO4)5].H2O (2).	Water	27-30	chorionic somatomammotropin hormone 2	Homo sapiens	141-144
16646520-0	2006	Vasopressin and nitric oxide synthesis after three days of water or food deprivation.	Water	59-64	arginine vasopressin	Rattus norvegicus	0-11
16646520-5	2006	Plasma osmolality and vasopressin levels were significantly elevated in water deprived (362.8 +/- 7.1 mOsm/kg H2O, 17.3 +/- 2.7 pg/ml, respectively, p &lt; 0.001) rats, but not in food deprived (339.9 +/- 5.0, 1.34 +/- 0.28) rats, compared to the controls (326.1 +/- 4.1, 1.47 +/- 0.32).	Water	72-77	arginine vasopressin	Rattus norvegicus	22-33
16614541-7	2006	Arginine vasopressin (AVP)-receptor antagonists promote aquaresis (electrolyte-sparing excretion of free water) by blocking the antidiuretic action of the hormone at the level of the collecting ducts.	Water	105-110	arginine vasopressin	Homo sapiens	9-20
16522429-3	2006	Previous studies from our laboratory have shown that the water channel aquaporin 1 (AQP1) is expressed in human fetal membranes from term pregnancies with normal amniotic fluid (AF) volume.	Water	57-62	aquaporin 1 (Colton blood group)	Homo sapiens	71-82
16522429-3	2006	Previous studies from our laboratory have shown that the water channel aquaporin 1 (AQP1) is expressed in human fetal membranes from term pregnancies with normal amniotic fluid (AF) volume.	Water	57-62	aquaporin 1 (Colton blood group)	Homo sapiens	84-88
15948717-4	2006	Previous studies in frog oocytes suggested that AQP8 was permeable to water, urea and ammonium, but no direct characterization had yet been reported.	Water	70-75	aquaporin 8	Homo sapiens	48-52
15948717-7	2006	In stopped-flow studies, all three AQP8 proteoliposomes showed water permeability, which was inhibited by mercuric chloride and rescued by 2-mercaptoethanol.	Water	63-68	aquaporin 8	Homo sapiens	35-39
15948717-9	2006	In the oocyte transport assay, hAQP8-injected oocytes showed significantly higher [14C]methylammonium uptake than water-injected oocytes.	Water	114-119	aquaporin 8	Homo sapiens	31-36
15948717-11	2006	All three AQP8 proteins transport water.	Water	34-39	aquaporin 8	Homo sapiens	10-14
16339203-4	2006	In this study we demonstrated that local testicular heat treatment of adult monkey with water at 43 C for 30 min once daily for 2 consecutive days was capable of activating reexpression of ck-18 in Sertoli cells, which was coincident with activation of ERK1/2 and Akt kinases.	Water	88-93	mitogen-activated protein kinase 3	Homo sapiens	253-259
16531283-1	2006	PURPOSE: To investigate the expression of cyclooxygenase (COX)-1, -2, and -3 RNA and protein in retinal pigment epithelial (ARPE-19) cells and in human neural (HN) cells exposed to the stress-inducing cytokines IL-1beta and TNF-a, the oxidizing peroxide H(2)O(2), the combination of TNF-alpha + H(2)O(2), and the lipofuscin fluorophore A2E.	Water	254-259	prostaglandin-endoperoxide synthase 1	Homo sapiens	42-76
16531283-1	2006	PURPOSE: To investigate the expression of cyclooxygenase (COX)-1, -2, and -3 RNA and protein in retinal pigment epithelial (ARPE-19) cells and in human neural (HN) cells exposed to the stress-inducing cytokines IL-1beta and TNF-a, the oxidizing peroxide H(2)O(2), the combination of TNF-alpha + H(2)O(2), and the lipofuscin fluorophore A2E.	Water	295-300	prostaglandin-endoperoxide synthase 1	Homo sapiens	42-76
16339203-4	2006	In this study we demonstrated that local testicular heat treatment of adult monkey with water at 43 C for 30 min once daily for 2 consecutive days was capable of activating reexpression of ck-18 in Sertoli cells, which was coincident with activation of ERK1/2 and Akt kinases.	Water	88-93	AKT serine/threonine kinase 1	Homo sapiens	264-267
16601568-2	2006	RESULTS: AT1-receptor activation by angiotensin II is not only involved in the regulation of blood pressure, water and sodium homeostasis, and control of other neurohumoral systems, but also leads to excessive production of reactive oxygen species and to hypertrophy, proliferation, migration, and apoptosis of vascular cells.	Water	109-114	angiotensinogen	Homo sapiens	36-50
16293701-7	2006	Compared with control (water treated) female rats, ethanol (1 g/kg ig) elicited hypotension that was associated with a significant increase in the aortic iNOS activity.	Water	23-28	nitric oxide synthase 2	Rattus norvegicus	154-158
16185919-7	2006	In patients, a highly significant correlation coefficient was found (r = 0.93, SEE 2.1 p = 0.01) between total body water (DEU) and height squared/resistance (Ht2/R).	Water	116-121	telomerase RNA component	Homo sapiens	159-164
16868672-3	2006	AQP8 water channels, which were initially cloned from rat pancreas, are expressed at the apical membrane of pancreatic acinar cells and contribute to their osmotic permeability.	Water	5-10	aquaporin 8	Rattus norvegicus	0-4
16868675-1	2006	Aquaporins (AQPs) and the cystic fibrosis transmembrane conductance regulator (CFTR) provide the molecular routes for transport of water and chloride, respectively, through many epithelial tissues.	Water	131-136	CF transmembrane conductance regulator	Homo sapiens	26-77
16868675-1	2006	Aquaporins (AQPs) and the cystic fibrosis transmembrane conductance regulator (CFTR) provide the molecular routes for transport of water and chloride, respectively, through many epithelial tissues.	Water	131-136	CF transmembrane conductance regulator	Homo sapiens	79-83
16868675-3	2006	This review is focused on the role of AQPs and CFTR in water and ion transport across corneal/conjunctival epithelia, corneal endothelium, ciliary epithelium, and retinal pigment epithelium.	Water	55-60	CF transmembrane conductance regulator	Homo sapiens	47-51
16539688-5	2006	The brain water content was decreased in ICH + EPO dose-dependently, as compared with ICH + vehicle.	Water	10-15	erythropoietin	Homo sapiens	47-50
16513617-6	2006	MBF-Ace was estimated using a simple 1-compartment model to estimate net tracer uptake, K1 (K1 (mL/g/min) = MBF.E; E = first-pass myocardial extraction of 1-11C-acetate) and washout (k2 (min(-1))) along with F(BM) (spillover correction) after fixing F(MM) (partial-volume correction) to values obtained from 15O-water modeling.	Water	312-317	angiotensin I converting enzyme	Rattus norvegicus	4-7
16484569-1	2006	Eight water-soluble components of aged garlic extract were evaluated to assess their potential to inhibit the activity of human cytochrome-P450 (CYP) enzymes.	Water	6-11	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	128-143
16484569-1	2006	Eight water-soluble components of aged garlic extract were evaluated to assess their potential to inhibit the activity of human cytochrome-P450 (CYP) enzymes.	Water	6-11	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	145-148
16539688-6	2006	The effect of EPO on the brain water content was inhibited by N(omega)-Nitro-L-arginine methyl ester hydrochloride (L-NAME, 10 mg/kg).	Water	31-36	erythropoietin	Homo sapiens	14-17
16465322-1	2006	Selective electrocatalytic hydrogenation of NO3- to N2 in water has successfully been achieved at room temperature using a membrane-electrode assembly (MEA) consisting of an H+ -conducting solid polymer electrolyte (Nafion-117) and a surface-modified Pt cathode.	Water	58-63	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
16114100-2	2006	The main physiological roles of AVP are the regulation of water balance and the control of blood pressure and adrenocorticotropin hormone (ACTH) secretion, mediated via three different subtypes of vasopressin receptors: V1a, V1b and V2 receptors (V1aR, V1bR and V2R, respectively).	Water	58-63	arginine vasopressin	Homo sapiens	32-35
16358346-1	2006	The effect of compressed CO2 on the solubilization of bovine serum albumin (BSA) in water/sodium bis-(2-ethylhexyl) sulfosuccinate (AOT)/isooctane reverse micelles was studied by observing phase behavior and recording UV-visible spectra under different conditions.	Water	84-89	albumin	Homo sapiens	61-74
22061730-2	2006	Compared to steam heating, cooking yields were significantly higher (P&lt;0.05) and instrumental texture measurements related to toughness significantly lower (P&lt;0.05) for RF cooked PG1 rolls and for meat injected with brines containing water binding dielectrically inactive additives (PG4) but not for brined rolls lacking the latter ingredients (PG2 and PG3).	Water	240-245	delta like non-canonical Notch ligand 1	Homo sapiens	351-354
16758988-1	2006	AIM: To establish a simple, rapid and accurate electroanalytical method for water soluble porphyrin meso-tetrakis-(4-sulfonatophenyl) porphyrin (TPPS4); to clarify the reaction between water soluble porphyrins and bovine serum albumin (BSA); and to determine the interaction of TPPS4 with BSA in the absence of presence of cyclodextrins (CDs), separately.	Water	76-81	albumin	Homo sapiens	221-234
16758988-1	2006	AIM: To establish a simple, rapid and accurate electroanalytical method for water soluble porphyrin meso-tetrakis-(4-sulfonatophenyl) porphyrin (TPPS4); to clarify the reaction between water soluble porphyrins and bovine serum albumin (BSA); and to determine the interaction of TPPS4 with BSA in the absence of presence of cyclodextrins (CDs), separately.	Water	185-190	albumin	Homo sapiens	221-234
16471980-4	2006	Analysis of cyclic voltammograms shows that an insoluble product is being formed at the electrode surface, which is attributed to the formation of ThO2 by reaction with water.	Water	169-174	THO complex 2	Homo sapiens	147-151
16437171-4	2006	Computer simulations of the catalyzed Ti(II)-Co(III) reaction in perchlorate-triflate media yield relative rates for reduction by the proposed active [Ti(II)(H2O)(n-1)]2+ intermediate; k(Br)/k(I) = 8.	Water	158-161	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	45-52
16471901-6	2006	For understanding the inhibitory mechanism, extensive molecular docking, molecular dynamics simulations, and binding free-energy calculations have been performed in this study to predict the most favorable structures of CD4-EGCG, gp120-CD4, and gp120-CD4-EGCG binding complexes in water.	Water	281-286	CD4 molecule	Homo sapiens	220-223
16534851-0	2006	Cloning and characterization of porcine aquaporin 1 water channel expressed extensively in gastrointestinal system.	Water	52-57	aquaporin-1	Cricetulus griseus	40-51
16434242-7	2006	The current study describes an enantioselective method that utilises pre-column formation of fluorescent diastereomers that are resolved on a C18 HPLC column using a gradient of methanol and water.	Water	191-196	Bardet-Biedl syndrome 9	Homo sapiens	142-145
16471816-7	2006	On the other hand, heating the sample to approximately 130 K just above H2O desorption causes the thermodynamically expected reaction of AsCl3 with the substrate GaAs to form Ga chloride species and As0.	Water	72-75	achaete-scute family bHLH transcription factor 3	Homo sapiens	137-142
16451045-3	2006	We investigated the effects of NaF, NaCl, NaBr, and NaI on the molecular organization of H2O by a calorimetric methodology developed by us earlier.	Water	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
16455841-5	2006	A two-dimensional ground water flow model is used to illustrate how permeable reactive barriers such as these can be used to redirect ground water flow within riparian zones, potentially augmenting NO3- removal in this environment.	Water	25-30	NBL1, DAN family BMP antagonist	Homo sapiens	198-201
16455841-5	2006	A two-dimensional ground water flow model is used to illustrate how permeable reactive barriers such as these can be used to redirect ground water flow within riparian zones, potentially augmenting NO3- removal in this environment.	Water	141-146	NBL1, DAN family BMP antagonist	Homo sapiens	198-201
16052238-4	2006	We conclude that the changes observed in the different water phases differ both quantitatively and qualitatively during the opening of the PTP and the Bax alpha-induced permeability, and that the apoptotic mitochondria exhibit mixed properties between these model situations.	Water	55-60	BCL2 associated X, apoptosis regulator	Homo sapiens	151-154
16144968-2	2006	The mRNA level of this water channel in polydipsic STR/N mice was extremely reduced compared with that in normal ICR mice.	Water	23-28	NAD(P) dependent steroid dehydrogenase-like	Mus musculus	51-54
16144968-8	2006	The data imply that polydipsia in STR/N mice may have affected AQP2 mRNA transcription in the kidney, resulting in reduced AQP2 expression, which would contribute to a reduction in overretention of water.	Water	198-203	NAD(P) dependent steroid dehydrogenase-like	Mus musculus	34-37
16189291-3	2006	Arginine vasopressin (AVP) promotes renal water reabsorption via the V2 receptor, and its levels are increased in CHF.	Water	42-47	arginine vasopressin	Homo sapiens	0-20
16437573-2	2006	Arginine vasopressin (AVP), or antidiuretic hormone, is the principal physiological regulator of water and electrolyte balance, and disruption of the normal AVP response to osmotic stimuli is a common cause of dilutional hyponatremia in neurological disorders.	Water	97-102	arginine vasopressin	Homo sapiens	9-20
16221990-3	2006	AQP9 is abundantly expressed in the efferent ducts, the epididymis, and the vas deferens, where it could represent an important apical pathway for transmembrane water and solute movement.	Water	161-166	aquaporin 9	Rattus norvegicus	0-4
16288954-6	2006	In these enzymes, the lack of the three-residue insertion in loop 1 (183-189) as found in thrombin allied to compensatory mutations in the positions 187-185 and 222 effects a constriction in the water-filled channel that ends up by segregating the ion binding site from the S1 subsite.	Water	195-200	coagulation factor II, thrombin	Homo sapiens	90-98
16984090-0	2006	Hydruric response in Wistar and vasopressin-deficient Brattleboro rats to water load under conditions of increased brain serotonin level.	Water	74-79	arginine vasopressin	Rattus norvegicus	32-43
16174867-11	2006	The increased targeting of ENaC and AQP2 likely represents direct or compensatory effects to increase sodium and water reabsorption and to prevent volume depletion in response to prolonged ANP infusion.	Water	113-118	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	27-31
16320039-4	2006	The proposed ion chromatographic method was successfully applied to the serial determination of cations and anions in tap water and river water samples.	Water	122-127	SEC14 like lipid binding 2	Homo sapiens	118-121
16467332-5	2006	Expression of gamma interferon (IFN-gamma) and interleukin-10 (IL-10) was lower in both BSA- and LF-administered mice than in water administered mice, suggesting a nonspecific effect of protein ingestion.	Water	126-131	interferon gamma	Mus musculus	14-41
16380517-8	2006	Intracerebroventricular injection of Ad-AT1a-shRNA increased water intake with no effect on BP or HR.	Water	61-66	angiotensin II receptor, type 1a	Mus musculus	40-44
16467332-5	2006	Expression of gamma interferon (IFN-gamma) and interleukin-10 (IL-10) was lower in both BSA- and LF-administered mice than in water administered mice, suggesting a nonspecific effect of protein ingestion.	Water	126-131	interleukin 10	Mus musculus	63-68
17080642-8	2006	The alx8 mutant is drought tolerant, exhibits improved water-use efficiency and a number of drought-tolerance genes are upregulated.	Water	55-60	SAL1 phosphatase-like protein	Arabidopsis thaliana	4-8
16404618-2	2006	Ang II and the AT1 receptor play a critical role in the cell-signaling process responsible for the actions of renin-angiotensin system in the regulation of blood pressure, water-electrolyte homeostasis and cell growth.	Water	172-177	angiotensinogen	Rattus norvegicus	0-6
16537998-5	2006	In Water-fed groups, treatment with BPA resulted in lower titers of total IgE (P&lt;0.01) and higher levels IgG2a (P&lt;0.05) followed by a higher IFN-gamma (P&lt;0.05) and IL-12 (P&lt;0.05) with an intact IL-4.	Water	3-8	interferon gamma	Mus musculus	147-156
16322051-0	2006	Water transport by Na+-coupled cotransporters of glucose (SGLT1) and of iodide (NIS).	Water	0-5	solute carrier family 5 member 1	Homo sapiens	58-63
16322051-8	2006	For the rabbit SGLT1, 378+/-20 (n=18 oocytes) water molecules were cotransported along with the 2 Na+ ions and the glucose-analogue alpha-MDG (MW 194); using the larger sugar arbutin (MW 272) this number was reduced by a factor of at least 0.86+/-0.03 (15).	Water	46-51	solute carrier family 5 member 1	Homo sapiens	15-20
16365912-0	2006	Conformational analysis of a potent SSTR3-selective somatostatin analogue by NMR in water solution.	Water	84-89	somatostatin receptor 3	Homo sapiens	36-41
16430419-3	2006	The subsequent reabsorption of free water from the fluid collection, with the contribution of postoperative hypotonic intravenous fluid administration and possible transient inappropriate antidiuretic hormone (ADH) secretion resulted in acute dilutional hyponatremia and consequent seizures.	Water	36-41	arginine vasopressin	Homo sapiens	210-213
16329147-5	2006	When diet was supplemented with arginine (0.2% and 2% in drinking water), lack of Nos2 results in decreased tumorigenesis in both small intestine and colon.	Water	66-71	nitric oxide synthase 2, inducible	Mus musculus	82-86
16311720-1	2006	Previously (Wellner et al., Pflugers Arch 441:49-56, 2000) we suggested that the localization of the aquaporins (AQPs) AQP5 and AQP8 in the apical and basolateral membranes of rat submandibular gland (SMG) acinar cells, respectively, provides for transcellular water flow during saliva formation.	Water	261-266	aquaporin 8	Rattus norvegicus	128-132
16554088-0	2006	Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1beta in rats.	Water	55-60	interleukin 1 beta	Rattus norvegicus	114-122
16554088-1	2006	In the present study we investigated, the effect of third ventricle injections of IL-1beta on water and salt intake in fluid-deprived and sodium-depleted rats.	Water	94-99	interleukin 1 beta	Rattus norvegicus	82-90
16554088-2	2006	Central administration of IL-1beta significantly reduced water and salt intake in fluid-deprived animals and decreased salt intake in sodium-depleted rats.	Water	57-62	interleukin 1 beta	Rattus norvegicus	26-34
16554088-5	2006	The present results suggest that the activation of the central interleukinergic component by IL-1beta impairs the increase in water and salt intake induced by water deprivation and the enhancement in sodium appetite that follows sodium depletion.	Water	126-131	interleukin 1 beta	Rattus norvegicus	93-101
16411775-5	2006	Experiments performed with long-chain triglycerides showed that gastric lipase binds optimally to the oil-water interface at low pH values.	Water	106-111	lipase F, gastric type	Homo sapiens	64-78
16462098-1	2006	Meloxicam (MLX), a non-steroidal anti-inflammatory drug (NSAID) and a selective COX-2 inhibitor is a water insoluble drug (about 12 microg/ml).	Water	101-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
16411775-9	2006	These results indicate that the optimum activity of gastric lipase at acidic pH is only "apparent" and results from the fact that lipase adsorption at lipid-water interfaces is the pH-dependent limiting step in the overall process of insoluble substrate hydrolysis.	Water	157-162	lipase F, gastric type	Homo sapiens	52-66
16297853-1	2006	Three unusual substrates-bromide (Br(-)), nitrite (NO(2)(-)), and thiocyanate (SCN(-))-compete for oxidation by eosinophil peroxidase (EPO) in physiologic fluids in the presence of H(2)O(2) to yield, respectively, hypobromous acid (HOBr), nitrogen dioxide (NO(2)()), or hypothiocyanous acid (HOSCN).	Water	181-186	eosinophil peroxidase	Mus musculus	112-133
16297853-1	2006	Three unusual substrates-bromide (Br(-)), nitrite (NO(2)(-)), and thiocyanate (SCN(-))-compete for oxidation by eosinophil peroxidase (EPO) in physiologic fluids in the presence of H(2)O(2) to yield, respectively, hypobromous acid (HOBr), nitrogen dioxide (NO(2)()), or hypothiocyanous acid (HOSCN).	Water	181-186	eosinophil peroxidase	Mus musculus	135-138
16407156-1	2006	Water-specific aquaporins (AQP), such as the prototypical mammalian AQP1, stringently exclude the passage of solutes, ions, and even protons.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	68-72
16337024-12	2006	We conclude that NO3- suppressed the production of H2(g) by competing with water for Fe0 oxidation, especially at the beginning of water treatment when Fe0 is highly reactive.	Water	75-80	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
16337024-12	2006	We conclude that NO3- suppressed the production of H2(g) by competing with water for Fe0 oxidation, especially at the beginning of water treatment when Fe0 is highly reactive.	Water	131-136	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
16166591-1	2006	In vivo, bromide (Br(-)), nitrite (NO(2)(-)), and thiocyanate (SCN(-)) compete for oxidation by eosinophil peroxidase (EPO) and H(2)O(2), yielding, respectively, HOBr, NO(2)., and HOSCN.	Water	128-133	eosinophil peroxidase	Homo sapiens	119-122
16249312-3	2006	By binding to V2-type receptors located in the kidney, VP decreases the amount of water lost in urine.	Water	82-87	arginine vasopressin	Rattus norvegicus	55-57
16113050-3	2006	An effective and selective dose of an iNOS inhibitor, L-N6-(1-iminoethyl)lysine (L-NIL), for chronic peroral treatment was first determined (8 mg/l in drinking water) by measuring exhaled NO concentration and systemic arterial pressure after LPS injection under ketamine+xylazine anesthesia.	Water	160-165	nitric oxide synthase 2	Rattus norvegicus	38-42
16378437-9	2006	This indicates that the structure of the fibrinogen molecules on the probe is changed from an extended conformation in buffer to a flat conformation in water, with the former state allowing for stronger interaction with the polymer chains on the surface.	Water	152-157	fibrinogen beta chain	Homo sapiens	41-51
16539309-6	2006	CONCLUSION: We have established a high expression of AQP1 water channels in nasal polyp tissue and have suggested two mechanisms to explain this finding.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	53-57
16135541-0	2006	Polarized trafficking of the aquaporin-3 water channel is mediated by an NH2-terminal sorting signal.	Water	41-46	aquaporin 3	Canis lupus familiaris	29-40
16398513-4	2006	The results were interpreted in terms of the electrostatic and hydrophobic contributions to the stability of the different phases formed in the water-surfactant-HSA system.	Water	144-149	albumin	Homo sapiens	161-164
16428833-0	2006	Water-soluble complexes formed by natural polyphenols and bovine serum albumin: evidence from gel electrophoresis.	Water	0-5	albumin	Homo sapiens	65-78
16428833-1	2006	The formation of water-soluble complexes from combinations of various polyphenols and bovine serum albumin (BSA) was analyzed by gel electrophoresis.	Water	17-22	albumin	Homo sapiens	93-106
16681431-0	2006	Utilizing ultrafiltration to remove alkaline phosphatase from clinical analyzer water.	Water	80-85	alkaline phosphatase, placental	Homo sapiens	36-56
16456226-3	2006	In this study, domain 1 of cell adhesion molecule CD2 (CD2-1) is used for studying amyloid fibril formation in a water/trifluoroethanol (TFE) mixture.	Water	113-118	complement C3d receptor 2	Rattus norvegicus	50-53
16456226-3	2006	In this study, domain 1 of cell adhesion molecule CD2 (CD2-1) is used for studying amyloid fibril formation in a water/trifluoroethanol (TFE) mixture.	Water	113-118	complement C3d receptor 2	Rattus norvegicus	55-60
16391281-8	2006	Compared to the control (0.18 mg L(-1)), surface water NO3- -N in the biosolids-amended watershed (2.23 mg L(-1)) was consistently higher; however, it was still below the Illinois limit of 10 mg L(-1) for public and food-processing water supplies.	Water	49-54	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
16681431-5	2006	The release of ALP from various strains of bacteria identified in pure water was demonstrated (10-30 x 10(6) cfu/mL released 6-10 microU/microL).	Water	71-76	alkaline phosphatase, placental	Homo sapiens	15-18
16681431-6	2006	It was shown that ultrafiltration is totally efficient in removing ALP from water, while residual ALP activity (2.21 microU/microL after filtration of an ALP solution of 6.22 microU/microL) was observed after filtration using a 0.22-mum filter.	Water	76-81	alkaline phosphatase, placental	Homo sapiens	67-70
16157656-1	2006	The cystic fibrosis transmembrane conductance regulator (CFTR) functions as a Cl- channel important in transepithelial salt and water transport.	Water	128-133	CF transmembrane conductance regulator	Homo sapiens	4-55
16809911-0	2006	Glucagon-like peptide-1 is involved in sodium and water homeostasis in humans.	Water	50-55	glucagon	Homo sapiens	0-23
16809911-12	2006	In contrast to part A, oral water intake was reduced by 36% under GLP-1 treatment: 1,848 +/- 331 ml (placebo) vs. 1,181 +/- 177 ml (GLP-1; p = 0.0414).	Water	28-33	glucagon	Homo sapiens	66-71
16720988-6	2006	Aquaporin-1, water-only channels, are important for solute-free water transport from blood capillaries.	Water	13-18	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
16720988-6	2006	Aquaporin-1, water-only channels, are important for solute-free water transport from blood capillaries.	Water	64-69	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
17143008-2	2006	Colonic lesions were induced by 2.5% DSS in the drinking water for 7 days, and then the animals were fed with tap water for subsequent 7 days.	Water	114-119	nuclear RNA export factor 1	Rattus norvegicus	110-113
16157656-1	2006	The cystic fibrosis transmembrane conductance regulator (CFTR) functions as a Cl- channel important in transepithelial salt and water transport.	Water	128-133	CF transmembrane conductance regulator	Homo sapiens	57-61
16254729-1	2006	A young woman was found dead in a bath-tub with her facial orifices under water and current burn marks at the right big toe and at the neck near the hairline.	Water	74-79	TUB bipartite transcription factor	Homo sapiens	39-42
20141508-5	2006	This is achieved either by directly coordinating to the metal ion found in some metalloenzymes (CAs, CPA, STS), usually by means of one of the nitrogen atoms present in the sulfamide motif, or, as in the case of the cyclic sulfamides, acting as HIV protease inhibitors interacting with the catalytically critical aspartic acid residues of the active site by means of an oxygen atom belonging to the HN-SO(2)-NH motif that substitutes a catalytically essential water molecule.	Water	460-465	carboxypeptidase A1	Homo sapiens	101-104
16367756-1	2006	The catalytic competence of the natural thrombin mutant with deletion of the Lys9 residue in the A-chain (deltaK9) was found to be severely impaired, most likely due to modification of the 60-loop conformation and catalytic triad geometry, as supported by long molecular dynamics (MD) simulations in explicit water solvent.	Water	309-314	coagulation factor II, thrombin	Homo sapiens	40-48
16339784-6	2006	Quantification of low water potential-induced ABA and Pro accumulation in five ABA-insensitive mutants, abi1-1, abi2-1, abi3, abi4, and abi5, revealed that abi4 had increased Pro accumulation at low water potential, but a reduced response to exogenous ABA.	Water	22-27	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	126-130
16785828-3	2006	COX-2 is widely expressed throughout the kidney, and inhibition of this enzyme is contributory to reduced glomerular filtration, salt and water retention, and blood pressure elevation.	Water	138-143	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
17018402-2	2006	The measured gas phase PCB fluxes averaged about 880 +/- 660 ngm(-2)d(-1), which was higher than the fluxes calculated using simultaneously measured air and water concentrations for natural surface waters.	Water	157-162	pyruvate carboxylase	Homo sapiens	23-26
16413428-1	2006	OBJECTIVES: To (1) identify abnormalities in arginine vasopressin (AVP, a water-conserving hormone) secretion and release in nursing home (NH) residents with nighttime urinary incontinence (UI); and (2) perform a pilot test of desmopressin acetate (ddAVP, a synthetic analog of the naturally occurring hormone) replacement in these residents.	Water	74-79	arginine vasopressin	Homo sapiens	54-65
16413428-1	2006	OBJECTIVES: To (1) identify abnormalities in arginine vasopressin (AVP, a water-conserving hormone) secretion and release in nursing home (NH) residents with nighttime urinary incontinence (UI); and (2) perform a pilot test of desmopressin acetate (ddAVP, a synthetic analog of the naturally occurring hormone) replacement in these residents.	Water	74-79	arginine vasopressin	Homo sapiens	67-70
16339784-6	2006	Quantification of low water potential-induced ABA and Pro accumulation in five ABA-insensitive mutants, abi1-1, abi2-1, abi3, abi4, and abi5, revealed that abi4 had increased Pro accumulation at low water potential, but a reduced response to exogenous ABA.	Water	22-27	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	156-160
16719363-7	2006	Subsequently, our studies demonstrated that the water channel aquaporin-1 (AQP1) is also present at the zymogen granule membrane and participates in rapid GTP-induced and G(alphai3)-mediated vesicular water gating and swelling.	Water	48-53	aquaporin 1 (Colton blood group)	Homo sapiens	75-79
16231193-3	2006	We have performed several molecular dynamics simulations, to a total of over 250 ns, of a beta-hairpin peptide in water using GROMACS.	Water	114-119	amyloid beta precursor protein	Homo sapiens	88-94
16239266-13	2006	We suggest that glomerular VEGF contributes to the high physiological permeability of mammalian glomeruli to water through an action on endothelial cells.	Water	109-114	vascular endothelial growth factor A	Homo sapiens	27-31
16475353-9	2005	The reaction products produced by the media in domestic tap water had average As-to-Fe ratios that were approximately 25% higher than those for a commercially available adsorbent.	Water	60-65	SEC14 like lipid binding 2	Homo sapiens	56-59
17003572-1	2006	BACKGROUND/AIMS: Angiotensin II (ANG II) and dopamine (DA) are both important regulators of sodium and water transport across renal proximal tubules.	Water	103-108	angiotensinogen	Rattus norvegicus	17-31
17003572-1	2006	BACKGROUND/AIMS: Angiotensin II (ANG II) and dopamine (DA) are both important regulators of sodium and water transport across renal proximal tubules.	Water	103-108	angiotensinogen	Rattus norvegicus	33-39
16394041-1	2006	OBJECTIVE: To estimate the effect of water-based lubricant on the liquid-based Pap test.	Water	37-42	PDGFA associated protein 1	Homo sapiens	79-82
16360935-2	2006	The MeOH-soluble fractions of 25 samples, prepared from water extracts, demonstrated inhibitory activity more than 50% on the metabolism mediated by CYP3A4, and 21 samples on the metabolism mediated by CYP2D6.	Water	56-61	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	149-155
16618987-4	2006	If the concentration of H2O2 is high, catalase acts catalytically, i.e. removes H2O2 by forming H2O and O2 (catalatic reaction).	Water	24-27	catalase	Homo sapiens	38-46
16523529-5	2006	In this paper, a high-performance liquid chromatography/ultraviolet multi-stage mass spectrometry (HPLC-UV-MSn) study of the decomposition of decitabine in water and human plasma revealed that these previously unknown products are isomers of the intermediates formyl-1-beta-D-2"-deoxyribofuranosyl-3-guanylurea and 1-beta-D-2"-deoxyribofuranosyl-3-guanylurea.	Water	156-161	moesin	Homo sapiens	107-110
16541400-10	2006	Fe-EDTA/H2O2 and uncoupled CYP(Fe=O) may both initiate the reaction, the latter in an attempt to reduce the ferryl oxygen to water.	Water	125-130	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	27-30
16363796-10	2005	A comparison of the NIPs and tonoplast-intrinsic proteins (TIP) shows that the H2 residue can predict the transport profile for water and glycerol with histidine found in TIP-like aquaporins, tryptophan found in aquaglyceroporins (NIP I), and alanine found in water-impermeable glyceroporins (AtNIP6;1).	Water	128-133	NOD26-like intrinsic protein 6;1	Arabidopsis thaliana	293-301
16311642-2	2005	Thus, the thermodynamic product of the reaction between cis,fac-[RuCl(2)(dmso-S)(3)(dmso-O)]() and cbdc in a number of different reaction conditions is the dinuclear species with two bridging cbdc units fac-[Ru(micro-cbdc-O,O")(dmso-S)(3)(H(2)O)](2) (2).	Water	239-244	FA complementation group C	Homo sapiens	60-63
16311642-2	2005	Thus, the thermodynamic product of the reaction between cis,fac-[RuCl(2)(dmso-S)(3)(dmso-O)]() and cbdc in a number of different reaction conditions is the dinuclear species with two bridging cbdc units fac-[Ru(micro-cbdc-O,O")(dmso-S)(3)(H(2)O)](2) (2).	Water	239-244	FA complementation group C	Homo sapiens	203-206
16183271-0	2005	A thiolate ligand on a cytochrome P-450 mimic permits the use of simple environmentally benign oxidants for biomimetic steroid hydroxylation in water.	Water	144-149	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	23-39
16474991-7	2006	The protective effect of the CMSD water extracts on Abeta-induced neuronal death was also observed by lactate dehydrogenase assay using cultured astrocyte cells.	Water	34-39	histocompatibility 2, class II antigen A, beta 1	Mus musculus	52-57
16474991-8	2006	Abeta-induced cell death was protected by the water extract of CMSD in a dose-dependent manner, and 25-50 microg/ml was the most effective concentration.	Water	46-51	histocompatibility 2, class II antigen A, beta 1	Mus musculus	0-5
16307385-1	2006	The adsorption of insulin at an oil-water interface was studied with fluorescence correlation spectroscopy (FCS).	Water	36-41	insulin	Homo sapiens	18-25
16343045-2	2006	Repeated cooling of the legs (immersion into 12 degrees C water up to the knees for 30 min, 20 times during 4 weeks = local cold adaptation - LCA) attenuated the initial increase in heart rate and blood pressure currently observed in control subjects immersed in cold water up to the knees.	Water	58-63	clathrin light chain A	Homo sapiens	142-145
16343045-2	2006	Repeated cooling of the legs (immersion into 12 degrees C water up to the knees for 30 min, 20 times during 4 weeks = local cold adaptation - LCA) attenuated the initial increase in heart rate and blood pressure currently observed in control subjects immersed in cold water up to the knees.	Water	268-273	clathrin light chain A	Homo sapiens	142-145
17332683-2	2006	In this study, we examined the effect of a ruthenium-based water-soluble CO carrier (CORM-3) on lipopolysaccharide (LPS)- and interferon-gamma (INF-gamma)-induced inflammatory responses in BV-2 microglial cells and explored the possible mechanisms of action.	Water	59-64	interferon gamma	Mus musculus	126-153
16125866-13	2006	These moderate differences in neuropsychological performance indicate that in human FNDI parvocellular vasopressin systems that supply the brain may be less affected or give no such serious disabilities, than the magnocellular hypothalamo-neurohypophysial system that provides vasopressin for endocrine regulation of water homeostasis.	Water	317-322	arginine vasopressin	Homo sapiens	103-114
16140029-6	2006	When the mice were provided with Dox in drinking water (0.5mg/ml in 5% sucrose), there was significant release of IFN-gamma in lavage fluid by ELISA in comparison to mice on water/sucrose alone (399+/-74 pg/ml vs undetectable, p&lt;0.01).	Water	49-54	interferon gamma	Mus musculus	114-123
16464787-10	2006	CONCLUSIONS: In CHF, furosemide increased the vasopressin level, which stimulated water reabsorption via the APQ2 water channels.	Water	82-87	arginine vasopressin	Homo sapiens	46-57
16464787-10	2006	CONCLUSIONS: In CHF, furosemide increased the vasopressin level, which stimulated water reabsorption via the APQ2 water channels.	Water	114-119	arginine vasopressin	Homo sapiens	46-57
16464787-11	2006	This is most likely a compensatory phenomenon in addition to the increase in the renin-angiotensin system to prevent excess loss of sodium and water.	Water	143-148	renin	Homo sapiens	81-86
16150901-1	2005	In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water transport by vasopressin.	Water	78-83	arginine vasopressin	Homo sapiens	97-108
16368010-0	2005	Computer simulation of partitioning of ten pentapeptides Ace-WLXLL at the cyclohexane/water and phospholipid/water interfaces.	Water	86-91	angiotensin I converting enzyme	Homo sapiens	57-60
16368010-0	2005	Computer simulation of partitioning of ten pentapeptides Ace-WLXLL at the cyclohexane/water and phospholipid/water interfaces.	Water	109-114	angiotensin I converting enzyme	Homo sapiens	57-60
16246107-0	2005	Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.	Water	65-70	arginine vasopressin	Homo sapiens	44-55
16246107-5	2005	An example of a cAMP-dependent process requiring compartmentalization of cAMP/PKA signals is arginine-vasopressin-regulated water reabsorption in renal principal cells.	Water	124-129	arginine vasopressin	Homo sapiens	102-113
16084007-1	2005	The effects of spin state of water molecules on its absorption on lyophilized DNA, lysozyme and some inorganic sorbents were studied.	Water	29-34	lysozyme	Homo sapiens	83-91
16084727-0	2005	Water-soluble chitosan derivatives as a BACE1 inhibitor.	Water	0-5	beta-secretase 1	Homo sapiens	40-45
16084727-1	2005	BACE1 (the beta-site APP-cleaving enzyme) inhibitory activities of water-soluble chitosan derivatives substituted with aminoethyl, dimethylaminoethyl and diethylaminoethyl groups were investigated.	Water	67-72	beta-secretase 1	Homo sapiens	0-5
16133142-4	2005	We describe the temporal expression and appearance of aquaporin-1 (AQP1) which is important for water transfer across adult choroid plexuses.	Water	96-101	aquaporin 1 (Colton blood group)	Homo sapiens	54-65
16133142-4	2005	We describe the temporal expression and appearance of aquaporin-1 (AQP1) which is important for water transfer across adult choroid plexuses.	Water	96-101	aquaporin 1 (Colton blood group)	Homo sapiens	67-71
16375696-1	2005	Cytochrome P450 (CYP) is a group of enzymes that metabolize drugs to a more water-soluble form, rendering them available for renal excretion.	Water	76-81	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
16375696-1	2005	Cytochrome P450 (CYP) is a group of enzymes that metabolize drugs to a more water-soluble form, rendering them available for renal excretion.	Water	76-81	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
16123155-1	2005	Central injections of angiotensin II (AngII) increase both water and NaCl intake.	Water	59-64	angiotensinogen	Rattus norvegicus	22-36
16123155-1	2005	Central injections of angiotensin II (AngII) increase both water and NaCl intake.	Water	59-64	angiotensinogen	Rattus norvegicus	38-43
16272802-6	2005	As for the association with environmental factors, p53 mutations occurred with higher frequency in patients with a daily intake of spicy foods and in those who used unboiled well water in the low-incidence area.	Water	179-184	tumor protein p53	Homo sapiens	51-54
16133124-2	2005	Recently, we have shown that water deprivation leads to the activation of vasopressin (VP) secretion and expression of Bcl-2 and caspase-9 apototic proteins in the hypothalamus of the rat brain.	Water	29-34	arginine vasopressin	Rattus norvegicus	74-85
16133124-2	2005	Recently, we have shown that water deprivation leads to the activation of vasopressin (VP) secretion and expression of Bcl-2 and caspase-9 apototic proteins in the hypothalamus of the rat brain.	Water	29-34	arginine vasopressin	Rattus norvegicus	87-89
16133124-2	2005	Recently, we have shown that water deprivation leads to the activation of vasopressin (VP) secretion and expression of Bcl-2 and caspase-9 apototic proteins in the hypothalamus of the rat brain.	Water	29-34	BCL2, apoptosis regulator	Rattus norvegicus	119-124
16133124-2	2005	Recently, we have shown that water deprivation leads to the activation of vasopressin (VP) secretion and expression of Bcl-2 and caspase-9 apototic proteins in the hypothalamus of the rat brain.	Water	29-34	caspase 9	Rattus norvegicus	129-138
16133124-4	2005	We found that water deprivation leads to simultaneous activation of synthesis of VP and p53 and Bcl-2 apoptotic proteins in the mouse brain.	Water	14-19	B cell leukemia/lymphoma 2	Mus musculus	96-101
16319884-1	2005	Lens-specific aquaporin-0 (AQP0) functions as a specific water pore and forms the thin junctions between fibre cells.	Water	57-62	major intrinsic protein of lens fiber	Homo sapiens	14-25
16319884-1	2005	Lens-specific aquaporin-0 (AQP0) functions as a specific water pore and forms the thin junctions between fibre cells.	Water	57-62	major intrinsic protein of lens fiber	Homo sapiens	27-31
16319884-4	2005	In the centre of the water pathway, the closed pore in junctional AQP0 retains only three water molecules, which are too widely spaced to form hydrogen bonds with each other.	Water	21-26	major intrinsic protein of lens fiber	Homo sapiens	66-70
16319884-4	2005	In the centre of the water pathway, the closed pore in junctional AQP0 retains only three water molecules, which are too widely spaced to form hydrogen bonds with each other.	Water	90-95	major intrinsic protein of lens fiber	Homo sapiens	66-70
15993982-4	2005	Under a drying condition where the water inflow from outside the body was eliminated, Ang II suppressed body weight loss, but Ang III did not.	Water	35-40	angiotensinogen	Homo sapiens	86-92
16290184-0	2005	Removal of As(III) and As(V) from water using a natural Fe and Mn enriched sample.	Water	34-39	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-28
16094632-6	2005	The membrane was demonstrated to resist physiological transmural pressure (burst pressure resistance &gt;500 mm Hg) and presented a high-water permeation resistance (1 mL/cm(2) min(-1) at 120 mmHg).	Water	137-142	CD59 molecule (CD59 blood group)	Homo sapiens	177-183
16126234-2	2005	Octadecylsilane (C18) solid phase extraction (SPE) extracts of produced water were exposed to DR-CALUX cells for 24h in order to investigate the contribution in potency from compounds that are stable to metabolism by the CALUX cells during exposure.	Water	72-77	Bardet-Biedl syndrome 9	Homo sapiens	17-20
16023827-1	2005	Foods and drinking water are the main sources of human exposure to inorganic arsenic [As(III) and As(V)].	Water	19-24	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	98-103
16272802-8	2005	Thus, higher frequency of spicy food intake and use of unboiled well water may be risk factors of esophageal cancer via p53 mutations in China.	Water	69-74	tumor protein p53	Homo sapiens	120-123
16305214-2	2005	Simulations are carried out for a model charge-transfer optical dye (p-nitroaniline) in SPC/E water in a range of temperatures down to the point of solvent ideal glass transition.	Water	94-99	proline rich protein gene cluster	Homo sapiens	88-91
16285719-0	2005	Strongly hydrogen-bonded water molecule present near the retinal chromophore of Leptosphaeria rhodopsin, the bacteriorhodopsin-like proton pump from a eukaryote.	Water	25-30	rhodopsin	Homo sapiens	94-103
16257394-2	2005	A key step in ROS detoxification is the conversion of hydrogen peroxide to water and oxygen by either catalase (CAT) or glutathione peroxidase (GPX).	Water	75-80	catalase	Homo sapiens	102-110
16257394-2	2005	A key step in ROS detoxification is the conversion of hydrogen peroxide to water and oxygen by either catalase (CAT) or glutathione peroxidase (GPX).	Water	75-80	catalase	Homo sapiens	112-115
16277535-1	2005	In situ infrared visible sum frequency generation spectroscopy (SFG) is used to examine the structure of water at the Ag-water interface in NaF and KF electrolyte solutions.	Water	105-110	C-X-C motif chemokine ligand 8	Homo sapiens	140-143
16154597-7	2005	Comparative analyses of SAPK and NF-kappaB for their responses to exogenous H(2)O(2) revealed that SAPK activation requires much higher H(2)O(2) concentrations than those required for NF-kappaB activation.	Water	76-81	mitogen-activated protein kinase 9	Homo sapiens	24-28
16154597-7	2005	Comparative analyses of SAPK and NF-kappaB for their responses to exogenous H(2)O(2) revealed that SAPK activation requires much higher H(2)O(2) concentrations than those required for NF-kappaB activation.	Water	76-81	mitogen-activated protein kinase 9	Homo sapiens	99-103
16261237-1	2005	N(epsilon)-stearoyl-lysine-ethyl-ester (C18-OE-Lys) operates as an efficient desymmetrizing agent for the generation of homochiral oligopeptides via a reaction catalyzed by silver ions in two-dimensional (2D) quasi-racemic crystallites of the corresponding thio-ester (C18-TE-Lys) self-assembled on water.	Water	299-304	Bardet-Biedl syndrome 9	Homo sapiens	40-43
16261237-1	2005	N(epsilon)-stearoyl-lysine-ethyl-ester (C18-OE-Lys) operates as an efficient desymmetrizing agent for the generation of homochiral oligopeptides via a reaction catalyzed by silver ions in two-dimensional (2D) quasi-racemic crystallites of the corresponding thio-ester (C18-TE-Lys) self-assembled on water.	Water	299-304	Bardet-Biedl syndrome 9	Homo sapiens	269-272
16102867-4	2005	When the enzyme was bioconjugated covalently with the water-soluble fibroin by glutaraldehyde, the enzyme kinetic properties and immune characteristics in vivo of the resulting silk fibroin-L-asparaginase (SF-ASNase) bioconjugates were investigated in detail.	Water	54-59	asparaginase and isoaspartyl peptidase 1	Homo sapiens	190-204
16202978-5	2005	Further, the expressions of mRNA and protein for IL-1beta were increased in colonic mucosa and pMphi from mice that received drinking water containing 5% DSS for 7 days (P &lt; 0.01, each).	Water	134-139	interleukin 1 beta	Mus musculus	49-57
16286160-5	2005	Excessive AVP secretion could contribute to both systolic and diastolic wall stress via V1a- and V2-mediated effects on the peripheral vasculature and on water retention.	Water	154-159	arginine vasopressin	Homo sapiens	10-13
16275913-10	2005	The effects of WNK3 on these transporters and their coexpression in renal epithelia implicate WNK3 in NaCl, water, and blood pressure homeostasis, perhaps via signaling downstream of vasopressin.	Water	108-113	WNK lysine deficient protein kinase 3 S homeolog	Xenopus laevis	94-98
16272281-6	2005	Surprisingly, TLR2-/-, TLR4-/-, and TLR9-/- mice were fully susceptible to EAU and had unaltered adaptive responses to interphotoreceptor retinoid-binding protein.	Water	75-78	toll-like receptor 4	Mus musculus	23-27
16242116-1	2005	Prior studies suggest that the hydrophobic surfactant proteins, SP-B and SP-C, promote adsorption of the lipids in pulmonary surfactant to an air-water interface by stabilizing a negatively curved rate-limiting structure that is intermediate between bilayer vesicles and the surface film.	Water	146-151	surfactant protein C	Homo sapiens	73-77
16129672-7	2005	We have shown that changes induced to the positions of Trp-741, Thr-877, and Met-895 allow for ligand accommodation within the AR binding pocket and that a water-mediated hydrogen bond to the backbone oxygen of Leu-873 and the ketone of hydroxyflutamide is present when bound to the T877A AR variant.	Water	156-161	androgen receptor	Homo sapiens	127-129
16129672-7	2005	We have shown that changes induced to the positions of Trp-741, Thr-877, and Met-895 allow for ligand accommodation within the AR binding pocket and that a water-mediated hydrogen bond to the backbone oxygen of Leu-873 and the ketone of hydroxyflutamide is present when bound to the T877A AR variant.	Water	156-161	androgen receptor	Homo sapiens	289-291
16384070-1	2005	Dielectric relaxation spectroscopy of pressure amorphized hexagonal ice shows that water"s high-density amorphous form relaxes in approximately 1 s at 140 K and 1 GPa and that the relaxation is virtually unaffected by pressure.	Water	83-88	glycophorin A (MNS blood group)	Homo sapiens	163-166
15956775-12	2005	These results suggest that the increased protein abundance of ENaC subunits as well as the increased apical targeting of AQP2 may contribute to renal sodium and water retention observed during the development of hypertension in SHR.	Water	161-166	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	62-66
16262287-4	2005	A (PAH-Naf)(n) film possesses a water contact angle of around 105 degrees, whereas the contact angle of a (PAH-Naf)(4)-(PAH-PAA)(m) multilayer is around 50 degrees.	Water	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	7-10
16215756-12	2005	Linear calibration plots were obtained for Cd2+ in acidified tap water at concentrations ranging from 2 x 10(-8) to 1 x 10(-7) mol L(-1) and from 1 x 10(-7) to 1 x 10(-6) mol L(-1) with relative standard deviations of 5% (n = 15) at the 1 x 10(-7) mol L(-1) level.	Water	65-70	SEC14 like lipid binding 2	Homo sapiens	61-64
16020523-0	2005	Inhibition of vasopressin secretion when dehydrated rats drink water.	Water	63-68	arginine vasopressin	Rattus norvegicus	14-25
16020523-1	2005	The present study determined whether vasopressin (VP) secretion is inhibited by an oropharyngeal signal associated with swallowing fluids when dehydrated rats drink water, as it is when dehydrated dogs are used as experimental subjects (Thrasher, TN, Keil LC, and Ramsay DJ.	Water	165-170	arginine vasopressin	Rattus norvegicus	37-48
16020523-1	2005	The present study determined whether vasopressin (VP) secretion is inhibited by an oropharyngeal signal associated with swallowing fluids when dehydrated rats drink water, as it is when dehydrated dogs are used as experimental subjects (Thrasher, TN, Keil LC, and Ramsay DJ.	Water	165-170	arginine vasopressin	Rattus norvegicus	50-52
16020523-3	2005	VP levels in systemic plasma (pVP) fell rapidly when rats drank water after overnight water deprivation.	Water	64-69	arginine vasopressin	Rattus norvegicus	0-2
16020523-3	2005	VP levels in systemic plasma (pVP) fell rapidly when rats drank water after overnight water deprivation.	Water	86-91	arginine vasopressin	Rattus norvegicus	0-2
16283717-0	2005	Calorimetric and structural investigation of the interaction between bovine serum albumin and high molecular weight dextran in water.	Water	127-132	albumin	Homo sapiens	76-89
16254391-4	2005	Cooling of preheated human insulin-poly(ethylene glycol)-water solutions results in the facile formation of insulin particles.	Water	57-62	insulin	Homo sapiens	27-34
16254391-4	2005	Cooling of preheated human insulin-poly(ethylene glycol)-water solutions results in the facile formation of insulin particles.	Water	57-62	insulin	Homo sapiens	108-115
16303640-6	2005	In addition, effect of valsartan on Ang II stimulated drinking of water was tested.	Water	66-71	angiotensinogen	Rattus norvegicus	36-42
16113688-3	2005	Vasopressin (AVP) is of major importance in the pathogenesis of water retention and hyponatremia in cirrhosis.	Water	64-69	arginine vasopressin	Rattus norvegicus	0-11
16404879-3	2005	Moscow tap water served as a control for all waters and was Moscow dechlorinated water after ozone-sorption purification, by passing Moscow tap water from a tap into a 3-liter vessel through a household ozone device for 5 min and then passing it through a household coal filter (500 ml).	Water	11-16	nuclear RNA export factor 1	Rattus norvegicus	7-10
16006463-2	2005	The renin-angiotensin system (RAS) is directly concerned with sodium and water homeostasis.	Water	73-78	renin	Homo sapiens	4-9
16260425-3	2005	The present study tests the hypothesis that the same GHRH regimen applied in women will: (i) elevate both IGF-I and GH concentrations; and (ii) reduce abdominal visceral fat mass, augment total body water and enhance functional performance.	Water	199-204	growth hormone releasing hormone	Homo sapiens	53-57
16260425-6	2005	RESULTS: GHRH administration stimulated: (i) a mean 98 +/- 14% elevation of overnight GH concentrations after administration of the peptide for 1 and 3 months (P &lt; 0.005); (ii) a sustained 71 +/- 3.5% rise in IGF-I concentrations over the interval from 2 weeks to 3 months (P &lt; 0.0012); (iii) a 16 +/- 7% reduction in abdominal visceral fat mass (P = 0.029) and a 14 +/- 5% increase in tri-tiated water space (P &lt; 0.025); (iv) an abbreviation of the times required to walk 30 m (P = 0.015) and ascend two flights of stairs (P = 0.003).	Water	403-408	growth hormone releasing hormone	Homo sapiens	9-13
16220067-2	2005	Tolvaptan (Otsuka) is an orally administered nonpeptide vasopressin (VP) V2 receptor antagonist that inhibits water reabsorption in the kidney by competitively blocking VP binding, resulting in water diuresis without significantly changing total electrolyte excretion.	Water	110-115	arginine vasopressin receptor 2	Homo sapiens	56-84
16309259-2	2005	Recent small-angle X-ray and neutron scattering data indicate that the density of water on the surface of lysozyme is significantly higher than in bulk water.	Water	82-87	lysozyme	Homo sapiens	106-114
16309259-2	2005	Recent small-angle X-ray and neutron scattering data indicate that the density of water on the surface of lysozyme is significantly higher than in bulk water.	Water	152-157	lysozyme	Homo sapiens	106-114
16309402-6	2005	RESULTS: The aprotinin-treated animals required less cardioversions for ventricular arrhythmias (1.0 +/- 0.7 vs. 3.6 +/- 0.6; p &lt; 0.001), accumulated less lung water (1.0 +/- 0.2% change vs. 6.2 +/- 0.9% change; p = 0.038), had more complete coronary relaxation to bradykinin (34.1 +/- 5.9% change vs. 9.2 +/- 3.5% change; p = 0.01), and had reduced infarct size (area necrosis/area risk = 20 +/- 1.1% vs. 39 +/- 1.2%; p = 0.003).	Water	163-168	pancreatic trypsin inhibitor-like	Sus scrofa	13-22
16239747-2	2005	This article, by computing these lysozyme crystals" atomic structures, obtained by the diffraction patterns of microfocused synchrotron radiation, provides a possible mechanism for this increased stability, namely a significant decrease in water content accompanied by a minor but significant alpha-helix increase.	Water	240-245	lysozyme	Homo sapiens	33-41
16111891-4	2005	The control group rats received tap water.	Water	36-41	nuclear RNA export factor 1	Rattus norvegicus	32-35
16278617-1	2005	OBJECTIVE: Regarding the growing use of alternative therapies for peri- or postmenopausal symptoms, we evaluated the effect of a water extract of Angelica sinensis (dong quai), used for peri- or postmenopausal relief, on the proliferation of estrogen receptor-positive (MCF-7) and negative (BT-20) breast cancer cells in vitro.	Water	129-134	estrogen receptor 1	Homo sapiens	242-259
16408643-5	2005	In 10 aged men, nocturia was due to a decrease of vasopressin secretion which resulted in a decrease of the solute free water reabsorption and an increase of diuresis.	Water	120-125	arginine vasopressin	Homo sapiens	50-61
16145695-11	2005	VC &lt;60% predicted, IC &lt;30 ml/kg, TLC &lt;60% predicted, and MIP &lt;60 cm H2O correlated with postoperative MV &gt;or=3 days (P &lt; 0.05).	Water	80-83	major intrinsic protein of lens fiber	Homo sapiens	66-69
16145695-13	2005	FEV1 &lt;40% predicted, VC &lt;60% predicted, IC &lt;30 ml/kg, TLC &lt;60% predicted, MIP &lt;60 cm H2O, and neuromuscular disease each correlated with prolonged postoperative MV.	Water	100-103	major intrinsic protein of lens fiber	Homo sapiens	86-89
15936089-2	2005	CFTR is a cAMP-regulated chloride channel localized primarily at the apical or luminal surfaces of epithelial cells lining the airway, gut, exocrine glands, etc., where it is responsible for transepithelial salt and water transport.	Water	216-221	CF transmembrane conductance regulator	Homo sapiens	0-4
16160878-8	2005	Intracerebroventricular injection of U-II also caused an increase in: food intake at doses of 100 and 1,000 ng/mouse, water intake at doses of 100-10,000 ng/mouse, and horizontal locomotion activity at a dose of 10,000 ng/mouse.	Water	118-123	urotensin 2	Mus musculus	37-41
16241141-7	2005	This second phase, monoclinic P2(1)/c, consists of isolated [Cu(3)L(NO(3))(5)](+) and (NO(3))(-) ions which accommodate water molecules in the crystal lattice.	Water	120-125	cyclin dependent kinase inhibitor 1A	Homo sapiens	30-37
16227078-8	2005	The water-soluble fraction of potassium, lead and manganese increased in both P2 and P5.	Water	4-9	tissue factor pathway inhibitor 2	Homo sapiens	78-87
16241145-1	2005	The o-phenylenediamine-derived disulfonamide ligands 1 and 2 complex and efficiently extract Pb(II) from water into 1,2-dichloroethane via ion-exchange, in combination with 2,2"-bipyridine (97.5% and 95.0%, respectively, for 1:1 ligand-to-Pb ratios).	Water	105-110	submaxillary gland androgen regulated protein 3B	Homo sapiens	93-99
16182260-5	2005	Water and saline intakes were increased to a similar extent by 125 and 1250 pmol of [D-Asp1D-Arg2]AngII.	Water	0-5	angiotensinogen	Rattus norvegicus	98-103
16182260-7	2005	Pretreatment with EC33 or PC18 decreased water and saline intakes in response to [D-Asp1D-Arg2]AngII, while pretreatment with PC18 altered the time course of the [D-Arg1]AngIII-induced water and saline intakes.	Water	41-46	angiotensinogen	Rattus norvegicus	95-100
16229512-3	2005	In this study, to further investigate this curious and novel phenomenon in surface and interface science, we synthesized another water-soluble ionic amphiphilic diblock copolymer poly(hydrogenated isoprene)-b-sodium poly(styrenesulfonate) PIp-h2-b-PSSNa by living anionic polymerization.	Water	129-134	prolactin induced protein	Homo sapiens	239-242
16085363-1	2005	Catalase is one of the enzymes that convert hydrogen peroxide (H2O2) to H2O presenting a protective role against free radicals.	Water	63-66	catalase	Mus musculus	0-8
16079130-1	2005	Catalase is a highly conserved heme-containing antioxidant enzyme known for its ability to degrade hydrogen peroxide into water and oxygen.	Water	122-127	catalase	Homo sapiens	0-8
16225876-2	2005	The single-channel water permeability, pf, was evaluated to be GlpF approximately AQPZ &gt; AQP1 &gt;&gt; AQP0, while their relative pore sizes were GlpF &gt;&gt; AQP1 &gt; AQPZ &gt;&gt; AQP0.	Water	19-24	aquaporin 1 (Colton blood group)	Homo sapiens	92-96
16225876-2	2005	The single-channel water permeability, pf, was evaluated to be GlpF approximately AQPZ &gt; AQP1 &gt;&gt; AQP0, while their relative pore sizes were GlpF &gt;&gt; AQP1 &gt; AQPZ &gt;&gt; AQP0.	Water	19-24	major intrinsic protein of lens fiber	Homo sapiens	106-110
16225876-2	2005	The single-channel water permeability, pf, was evaluated to be GlpF approximately AQPZ &gt; AQP1 &gt;&gt; AQP0, while their relative pore sizes were GlpF &gt;&gt; AQP1 &gt; AQPZ &gt;&gt; AQP0.	Water	19-24	aquaporin 1 (Colton blood group)	Homo sapiens	163-167
16225876-2	2005	The single-channel water permeability, pf, was evaluated to be GlpF approximately AQPZ &gt; AQP1 &gt;&gt; AQP0, while their relative pore sizes were GlpF &gt;&gt; AQP1 &gt; AQPZ &gt;&gt; AQP0.	Water	19-24	major intrinsic protein of lens fiber	Homo sapiens	187-191
16298260-5	2005	EPO secretion increases when the intrathoracic volume decreases 24 hours after water immersion or after endurance exercise when a negative water balance prevails.	Water	79-84	erythropoietin	Homo sapiens	0-3
16210649-3	2005	In this paper we report on studies examining how the ROS hydrogen peroxide (H(2)O(2)) affects the production of MMP-1, COX-2, and PGE(2).	Water	76-81	prostaglandin-endoperoxide synthase 2	Homo sapiens	119-124
16190729-5	2005	In the resting form of CYP3A4, a structural water molecule is bound to the sixth coordination position of the heme iron, stabilizing the octahedral coordination geometry.	Water	44-49	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	23-29
16172251-0	2005	Thrombin increases lung water by decreasing Na,K-ATPase activity.	Water	24-29	coagulation factor II, thrombin	Homo sapiens	0-8
16184761-1	2005	In this study, we investigated the role played by cytoplasmic catalase (Ctt1) in resistance against water loss using the yeast Saccharomyces cerevisiae as eukaryotic cell model.	Water	100-105	catalase T	Saccharomyces cerevisiae S288C	72-76
16197516-0	2005	Memory strengthening by a real-life episode during reconsolidation: an outcome of water deprivation via brain angiotensin II.	Water	82-87	angiotensinogen	Homo sapiens	110-124
15883844-3	2005	The model explains (1) the observed enhancement of enzymatic activity by lipids with flexible, neutral, water-soluble polymers linked to their head groups and (2) the lag-burst kinetics of sPLA(2).	Water	104-109	phospholipase A2 group X	Homo sapiens	189-196
16179736-2	2005	A G alphai3-phospholipase A2 (PLA2)-mediated involvement of the water channel aquaporin-1 (AQP1) in the regulation of secretory vesicle swelling in the exocrine pancreas has been previously reported.	Water	64-69	phospholipase A2 group VI	Homo sapiens	4-28
16179736-2	2005	A G alphai3-phospholipase A2 (PLA2)-mediated involvement of the water channel aquaporin-1 (AQP1) in the regulation of secretory vesicle swelling in the exocrine pancreas has been previously reported.	Water	64-69	phospholipase A2 group VI	Homo sapiens	30-34
16179736-2	2005	A G alphai3-phospholipase A2 (PLA2)-mediated involvement of the water channel aquaporin-1 (AQP1) in the regulation of secretory vesicle swelling in the exocrine pancreas has been previously reported.	Water	64-69	aquaporin 1 (Colton blood group)	Homo sapiens	91-95
16179736-4	2005	Results from the study demonstrate that water channels AQP1 and AQP6, and the heterotrimeric Go protein are associated with SVs and participate in their swelling.	Water	40-45	aquaporin 1 (Colton blood group)	Homo sapiens	55-59
16168010-2	2005	AIMS: The interplay between natriuretic dopamine and antinatriuretic angiotensin II represents an important mechanism for the regulation of renal sodium and water excretion.	Water	157-162	angiotensinogen	Rattus norvegicus	69-83
16173949-12	2005	In conclusion, neonatal ACE inhibition in rats induces pronounced alterations in renal haemodynamics and function, characterized by reductions in ERPF and GFR, increased RVR and impaired tubular sodium and water reabsorption, which are evident at weaning.	Water	206-211	angiotensin I converting enzyme	Rattus norvegicus	24-27
16197516-8	2005	We show that memory reconsolidation, induced by training context re-exposure, is facilitated by a concurrent episode of water deprivation, which induces a raise in endogenous brain angiotensin II.	Water	120-125	angiotensinogen	Homo sapiens	181-195
16093449-3	2005	For elucidating the mechanism by which BK regulates renal water transport that contributes to its antihypertensive effect, aquaporin 2 (AQP2)-transfected collecting duct CD8 cells, expressing the BK type II receptor (BK2R), were used as an experimental model.	Water	58-63	kininogen 1	Homo sapiens	39-41
16051214-6	2005	Transfection of CF cells with CFTR cDNA or inhibition of non-CF cells with CFTR(inh)-172, respectively restored or decreased the water content and granule expansion, in parallel with changes in ion content.	Water	129-134	CF transmembrane conductance regulator	Homo sapiens	30-34
16051214-6	2005	Transfection of CF cells with CFTR cDNA or inhibition of non-CF cells with CFTR(inh)-172, respectively restored or decreased the water content and granule expansion, in parallel with changes in ion content.	Water	129-134	CF transmembrane conductance regulator	Homo sapiens	75-79
16186359-3	2005	In CCR5-deficient mice, we examined the role of CCR5 in the development of EAU induced by immunization with interphotoreceptor retinoid-binding protein (IRBP) peptide.	Water	75-78	chemokine (C-C motif) receptor 5	Mus musculus	48-52
16186359-7	2005	RESULTS: Immunization with hIRBP-p induced EAU in CCR5-deficient mice with a severity comparable to that in wild-type mice.	Water	43-46	chemokine (C-C motif) receptor 5	Mus musculus	50-54
16093448-3	2005	Patients who have congenital NDI and bear mutations in the AVPR2 or AQP2 genes have a "pure" NDI phenotype with loss of water but normal conservation of sodium, potassium, chloride, and calcium.	Water	120-125	arginine vasopressin receptor 2	Homo sapiens	59-64
16120822-1	2005	Water homeostasis in humans is regulated by vasopressin, which induces the translocation of homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells.	Water	0-5	arginine vasopressin	Homo sapiens	44-55
16107579-4	2005	In response to 36-h water deprivation, GD rats demonstrated significantly greater urine flow rate and decreased urine osmolality as compared with control rats at comparable serum osmolality and plasma vasopressin concentrations.	Water	20-25	arginine vasopressin	Rattus norvegicus	201-212
16120822-1	2005	Water homeostasis in humans is regulated by vasopressin, which induces the translocation of homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells.	Water	126-131	arginine vasopressin	Homo sapiens	44-55
16177191-0	2005	Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon.	Water	27-32	aquaporin 8	Rattus norvegicus	0-11
16035088-2	2005	This set is compatible with the most recent version of the GROMOS force field for proteins, nucleic acids, and lipids, and the SPC water model.	Water	131-136	proline rich protein gene cluster	Homo sapiens	127-130
16177193-8	2005	Of the 20 fecal water samples, 2 also weakly inhibited enzymatic activity of purified COX-2 (22-24% inhibition).	Water	16-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
16177191-7	2005	Moreover, the contribution of AQP-8 to overall water movement through isolated colonocytes was studied using RNA interference technology.	Water	47-52	aquaporin 8	Rattus norvegicus	30-35
16177193-10	2005	This study shows for the first time that human fecal water contains components that can affect both the COX-2 protein level and enzymatic activity.	Water	53-58	prostaglandin-endoperoxide synthase 2	Homo sapiens	104-109
16177191-11	2005	Inhibition of aquaporin-8 expression by small interfering RNA significantly decreased osmotic water permeability (approximately 38%; P &lt; 0.05).	Water	94-99	aquaporin 8	Rattus norvegicus	14-25
16177191-12	2005	Current results indicate that aquaporin-8 may play a major role in water movement through the colon by acting on the apical side of the superficial cells.	Water	67-72	aquaporin 8	Rattus norvegicus	30-41
16177193-0	2005	Human fecal water inhibits COX-2 in colonic HT-29 cells: role of phenolic compounds.	Water	12-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	27-32
16177193-2	2005	The aim of the present study was to screen for COX-2 inhibitors in samples of fecal water (the aqueous phase of feces) and investigate whether phenolic compounds are responsible for any observed effects on COX-2.	Water	84-89	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
16164634-11	2005	Binding of phosphorylated CREB to a CREB oligonucleotide was significantly increased after 0.5 mmol/L H(2)O(2) but decreased after 1 mmol/L H(2)O(2).	Water	102-107	cAMP responsive element binding protein 1	Mus musculus	26-30
16164646-1	2005	BACKGROUND: Although prolactin affects sodium and water transport across the plasma membrane and interacts with dopamine in the brain, its role in the kidney is unclear.	Water	50-55	prolactin	Rattus norvegicus	21-30
16164634-11	2005	Binding of phosphorylated CREB to a CREB oligonucleotide was significantly increased after 0.5 mmol/L H(2)O(2) but decreased after 1 mmol/L H(2)O(2).	Water	102-107	cAMP responsive element binding protein 1	Mus musculus	36-40
16383355-4	2005	Hydration dependence measurements find that a difference in the equilibrium water content for ferri and ferro cytochrome c is not sufficient to account for the large change in terahertz response.	Water	76-81	cytochrome c, somatic	Homo sapiens	110-122
16164646-9	2005	In rats, prolactin infusion resulted in an increase in urinary sodium, potassium, and water excretion.	Water	86-91	prolactin	Rattus norvegicus	9-18
15830390-14	2005	High ANP levels may play a role in maintaining water and electrolyte equilibrium during a state of inappropriate ADH secretion accompanying pneumonia.	Water	47-52	natriuretic peptide A	Homo sapiens	5-8
16834249-4	2005	The actual SigmaN proportional, variant [NO3-]1/2 dependence (at constant H) is consistent with NO2 hydrolysis: 2NO2 + H2O --&gt; NO3- + NO2- + 2H+, overtaking NO2 desorption, even below the eutectic point (-18 degrees C for aqueous NaNO3).	Water	119-122	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
16265774-0	2005	Postprandial water intake inhibits gastric antral motility with increase of cholecystokinin in humans.	Water	13-18	cholecystokinin	Homo sapiens	76-91
16265774-7	2005	RESULTS: At 4 min after water intake, there was a significant decrease in gastric antral motility and a significant increase in the plasma cholecystokinin level.	Water	24-29	cholecystokinin	Homo sapiens	139-154
16265774-9	2005	CONCLUSIONS: The rapid increase in cholecystokinin after water intake may be initiated by a feedback mechanism related to inflow of fatty chyme into the duodenum that inhibits gastric antral activity.	Water	57-62	cholecystokinin	Homo sapiens	35-50
16020454-1	2005	Water transport properties of the Na+-K+-2Cl- cotransporter (NKCC) were studied in cultures of pigmented epithelial cells (PE) from the ciliary body of the eye.	Water	0-5	solute carrier family 12 member 1	Homo sapiens	34-59
16020454-1	2005	Water transport properties of the Na+-K+-2Cl- cotransporter (NKCC) were studied in cultures of pigmented epithelial cells (PE) from the ciliary body of the eye.	Water	0-5	solute carrier family 12 member 1	Homo sapiens	61-65
16049272-8	2005	When trout were exposed to water collected from a site where triclopyr was used in combination with TPA, a concentration-dependent increase in Vtg expression was observed.	Water	27-32	LOC100136735	Oncorhynchus mykiss	143-146
16216580-2	2005	Multiple explicit-water molecular dynamics simulations of the apo and inhibitor bound structures of BACE indicate that both open- and closed-flap conformations are accessible at room temperature and should be taken into account for inhibitor design.	Water	18-23	beta-secretase 1	Homo sapiens	100-104
16834249-4	2005	The actual SigmaN proportional, variant [NO3-]1/2 dependence (at constant H) is consistent with NO2 hydrolysis: 2NO2 + H2O --&gt; NO3- + NO2- + 2H+, overtaking NO2 desorption, even below the eutectic point (-18 degrees C for aqueous NaNO3).	Water	119-122	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
16853223-3	2005	Affinity of PCB-n to the pyrenyl-tagged poly(methacrylic) acid (PMAA) or DNA was judged from the stability of the corresponding polyelectrolyte complexes in water-salt solutions at different pH values as monitored by fluorescence quenching techniques.	Water	157-162	pyruvate carboxylase	Homo sapiens	12-15
16134088-8	2005	Among the new synthesized copolymers (P1-P23), seven diblock or triblock samples (P3, P6, P7, P11, P12, P19, and P21) with higher hydrophilic building block populations were revealed to be water soluble under ambient temperature.	Water	189-194	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	99-102
16149817-1	2005	[reaction: see text] The title reactions, in 44 wt % ethanol-water at 25.0 degrees C, exhibit slightly curved Bronsted-type plots (log kN versus pKa of amines) with slopes beta1 = 0.1-0.44 (at high pKa) and beta2 ca.	Water	61-66	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	172-177
16342469-8	2005	The purpose of this study is to arrange the atmospheric water-soluble ionic species (SO4(2-) and NO3) investigations in the Asian region.	Water	56-61	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
16342469-9	2005	The data obtained here can also help to understand the sources, concentrations, phase distribution and health impact of atmospheric water-soluble ionic species (SO4(2-) and NO3-) in other Asian regions.	Water	132-137	NBL1, DAN family BMP antagonist	Homo sapiens	173-176
16853190-1	2005	It is found that at 10 K substrate temperature the donation of 3sNa charge to the ice film, which is regarded as a precursor for water deprotonation, is significantly reduced relative to 100 K. This observation is discussed on the basis of recent theoretical work, suggesting that a rearrangement of the water molecules at the outermost water surface is the prerequisite for hydration/solvation of the 3sNa electron in the water ice bulk.	Water	129-134	snail family transcriptional repressor 1	Homo sapiens	64-67
16112232-6	2005	The difference of pK1 of amine oxide monomer between D2O and H2O was about 0.5: pK1(D) approximately pK1(H) + 0.5.	Water	61-64	pyruvate kinase L/R	Homo sapiens	18-21
16112232-6	2005	The difference of pK1 of amine oxide monomer between D2O and H2O was about 0.5: pK1(D) approximately pK1(H) + 0.5.	Water	61-64	pyruvate kinase L/R	Homo sapiens	80-83
16112232-6	2005	The difference of pK1 of amine oxide monomer between D2O and H2O was about 0.5: pK1(D) approximately pK1(H) + 0.5.	Water	61-64	pyruvate kinase L/R	Homo sapiens	80-83
16853200-0	2005	Effect of preadsorbed water on the adsorption of p-xylene and m-xylene mixtures on BaX and BaY zeolites.	Water	22-27	BCL2 associated X, apoptosis regulator	Homo sapiens	83-86
15935361-1	2005	In this work, the gelation kinetics and fractal character of lysozyme gel matrices developed in tetramethylurea (TMU)-water media were investigated.	Water	118-123	lysozyme	Homo sapiens	61-69
16162327-5	2005	The highest concentration of water-soluble As(III)+As(V) (&gt;1.9 mg kg(-1)) was found where As(III) was present.	Water	29-34	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	51-56
16162327-7	2005	Pearson correlation coefficient between DHA and samples containing water-soluble As(V) (r=-0.87) was greater than that between DHA and total water-soluble arsenic (r=-0.57).	Water	67-72	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	81-86
16853190-1	2005	It is found that at 10 K substrate temperature the donation of 3sNa charge to the ice film, which is regarded as a precursor for water deprotonation, is significantly reduced relative to 100 K. This observation is discussed on the basis of recent theoretical work, suggesting that a rearrangement of the water molecules at the outermost water surface is the prerequisite for hydration/solvation of the 3sNa electron in the water ice bulk.	Water	129-134	snail family transcriptional repressor 1	Homo sapiens	403-406
16853190-1	2005	It is found that at 10 K substrate temperature the donation of 3sNa charge to the ice film, which is regarded as a precursor for water deprotonation, is significantly reduced relative to 100 K. This observation is discussed on the basis of recent theoretical work, suggesting that a rearrangement of the water molecules at the outermost water surface is the prerequisite for hydration/solvation of the 3sNa electron in the water ice bulk.	Water	304-309	snail family transcriptional repressor 1	Homo sapiens	64-67
16853190-1	2005	It is found that at 10 K substrate temperature the donation of 3sNa charge to the ice film, which is regarded as a precursor for water deprotonation, is significantly reduced relative to 100 K. This observation is discussed on the basis of recent theoretical work, suggesting that a rearrangement of the water molecules at the outermost water surface is the prerequisite for hydration/solvation of the 3sNa electron in the water ice bulk.	Water	304-309	snail family transcriptional repressor 1	Homo sapiens	64-67
16142959-2	2005	ATR/MIR in situ showed that the accumulation of PPA molecules near the GaAs surface increased with the water concentration in the solution.	Water	103-108	ATR serine/threonine kinase	Homo sapiens	0-3
16148937-3	2005	In mitochondria and many bacteria, the last enzyme complex in the electron transfer chain is cytochrome c oxidase (CytcO), which catalyses the four-electron reduction of O2 to H2O using electrons delivered by a water-soluble donor, cytochrome c.	Water	176-179	cytochrome c, somatic	Homo sapiens	93-105
16148937-3	2005	In mitochondria and many bacteria, the last enzyme complex in the electron transfer chain is cytochrome c oxidase (CytcO), which catalyses the four-electron reduction of O2 to H2O using electrons delivered by a water-soluble donor, cytochrome c.	Water	176-179	cytochrome c, somatic	Homo sapiens	232-244
16148937-3	2005	In mitochondria and many bacteria, the last enzyme complex in the electron transfer chain is cytochrome c oxidase (CytcO), which catalyses the four-electron reduction of O2 to H2O using electrons delivered by a water-soluble donor, cytochrome c.	Water	211-216	cytochrome c, somatic	Homo sapiens	93-105
16148937-3	2005	In mitochondria and many bacteria, the last enzyme complex in the electron transfer chain is cytochrome c oxidase (CytcO), which catalyses the four-electron reduction of O2 to H2O using electrons delivered by a water-soluble donor, cytochrome c.	Water	211-216	cytochrome c, somatic	Homo sapiens	232-244
15905169-4	2005	Purified, water-soluble ICln is able to insert into lipid bilayers to form ion channels.	Water	10-15	chloride nucleotide-sensitive channel 1A pseudogene 1	Homo sapiens	24-28
16240034-2	2005	DSC scans of glassy water prepared at 140 K exhibit on heating an endothermic step assignable to glass --&gt; liquid transition, with an onset temperature (T(g)) of 136 +/- 2 K on heating at 30 K min(-1).	Water	20-25	CD59 molecule (CD59 blood group)	Homo sapiens	196-202
15840771-1	2005	Circulating vasopressin levels change in hydrated and dehydrated conditions and thus control osmotic water permeability (P(f)) of the inner medullary collecting duct (IMCD).	Water	101-106	arginine vasopressin	Rattus norvegicus	12-23
16150284-12	2005	CONCLUSION: The presence of significant AQP9 messenger RNA and protein expression in ovine fetal membranes suggests that AQP9 may be a major water channel for intramembranous AF resorption in sheep.	Water	141-146	aquaporin-9	Ovis aries	40-44
16150284-12	2005	CONCLUSION: The presence of significant AQP9 messenger RNA and protein expression in ovine fetal membranes suggests that AQP9 may be a major water channel for intramembranous AF resorption in sheep.	Water	141-146	aquaporin-9	Ovis aries	121-125
16099321-2	2005	METHODS: Liver cirrhosis was produced by the administration of TAA (0.3 g/L of tap water) for a period of 3 months in rats.	Water	83-88	nuclear RNA export factor 1	Rattus norvegicus	79-82
16115624-1	2005	The V2 vasopressin receptor, a member of the rhodopsin subfamily of GPCRs, mediates arginine vasopressin control of water reabsorption in the kidney by activating Gs.	Water	116-121	arginine vasopressin	Homo sapiens	7-18
16115624-1	2005	The V2 vasopressin receptor, a member of the rhodopsin subfamily of GPCRs, mediates arginine vasopressin control of water reabsorption in the kidney by activating Gs.	Water	116-121	arginine vasopressin	Homo sapiens	93-104
16363471-6	2005	The results showed that the technique is satisfactory to determine Co(II) at trace level in water samples with a detection limit of 2.3 ng/ml.	Water	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
16061068-0	2005	Genomic structure of the proopiomelanocortin gene and expression during acute low-water stress in channel catfish.	Water	82-87	proopiomelanocortin b	Ictalurus punctatus	25-44
15994894-0	2005	Influence of the water structure on the acetylcholinesterase efficiency.	Water	17-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-60
15994894-1	2005	We have studied the catalytic efficiency of acetylcholinesterase (AChE) in various solutions with ion-disturbed water structure to explore the role that the water structure plays in the substrate-enzyme encounter.	Water	112-117	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-64
15994894-1	2005	We have studied the catalytic efficiency of acetylcholinesterase (AChE) in various solutions with ion-disturbed water structure to explore the role that the water structure plays in the substrate-enzyme encounter.	Water	112-117	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70
15994894-1	2005	We have studied the catalytic efficiency of acetylcholinesterase (AChE) in various solutions with ion-disturbed water structure to explore the role that the water structure plays in the substrate-enzyme encounter.	Water	157-162	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-64
15994894-1	2005	We have studied the catalytic efficiency of acetylcholinesterase (AChE) in various solutions with ion-disturbed water structure to explore the role that the water structure plays in the substrate-enzyme encounter.	Water	157-162	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70
15994894-3	2005	The influence of water structure on the degree of solvation and on the intramolecular mobility of AChE was investigated for different aqueous ionic solutions by small-angle x-ray scattering technique and depolarization fluorescence spectroscopy.	Water	17-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-102
15994894-4	2005	It was found that the encounter process between AChE and acetylthiocholine was promoted in solutions with less structured water.	Water	122-127	acetylcholinesterase (Cartwright blood group)	Homo sapiens	48-52
15994894-6	2005	The found experimental results suggest that the water structure may influence the substrate-enzyme encounter process by diminishing the AChE solvation shell and may help diffusion of the substrate through the gorge by enhancing the intramolecular mobility of AChE.	Water	48-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	136-140
15994894-6	2005	The found experimental results suggest that the water structure may influence the substrate-enzyme encounter process by diminishing the AChE solvation shell and may help diffusion of the substrate through the gorge by enhancing the intramolecular mobility of AChE.	Water	48-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	259-263
16104853-6	2005	Canonical correspondence analysis indicated that O2, NO3-, NO2- and depth were important environmental factors governing these communities along the biogeochemical gradient in the water column.	Water	180-185	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
16085184-10	2005	(3) Antisense phosphorothioate oligonucleotides against Smac/DIABLO markedly inhibited de novo synthesis of Smac/DIABLO and this effect was accompanied by decreased apoptosis and activation of caspase-3 and caspase-9 induced by H(2)O(2) (P&lt;0.05).	Water	228-233	diablo, IAP-binding mitochondrial protein	Mus musculus	56-60
16085184-10	2005	(3) Antisense phosphorothioate oligonucleotides against Smac/DIABLO markedly inhibited de novo synthesis of Smac/DIABLO and this effect was accompanied by decreased apoptosis and activation of caspase-3 and caspase-9 induced by H(2)O(2) (P&lt;0.05).	Water	228-233	diablo, IAP-binding mitochondrial protein	Mus musculus	61-67
16085184-10	2005	(3) Antisense phosphorothioate oligonucleotides against Smac/DIABLO markedly inhibited de novo synthesis of Smac/DIABLO and this effect was accompanied by decreased apoptosis and activation of caspase-3 and caspase-9 induced by H(2)O(2) (P&lt;0.05).	Water	228-233	diablo, IAP-binding mitochondrial protein	Mus musculus	108-112
16085184-10	2005	(3) Antisense phosphorothioate oligonucleotides against Smac/DIABLO markedly inhibited de novo synthesis of Smac/DIABLO and this effect was accompanied by decreased apoptosis and activation of caspase-3 and caspase-9 induced by H(2)O(2) (P&lt;0.05).	Water	228-233	diablo, IAP-binding mitochondrial protein	Mus musculus	113-119
15859948-12	2005	CONCLUSIONS: These results suggest that increases in the osmotic water permeability due to the expression of AQP2 are critical for a rapid activation of regulatory volume decrease mechanisms, which would be linked to cystic fibrosis transmembrane conductance regulator and to barium-sensitive potassium channels.	Water	65-70	CF transmembrane conductance regulator	Homo sapiens	217-268
16023638-7	2005	In contrast, there was higher expression in the dorsal motor nucleus of the vagus (DMV) of AT1aKO vs. Controls (0.6 +/- 0.1 vs. 0.9 +/- 0.1 microCi/g, Control vs. AT1aKO in water ad libitum group).	Water	173-178	angiotensin II receptor, type 1a	Mus musculus	91-94
16087478-4	2005	OBJECTIVE: To determine the effects of water-soluble aldehydes, obtained from thermally oxidized sunflower oil on the expression of CD36 scavenger receptor in human monocytes (THP-1 cells).	Water	39-44	GLI family zinc finger 2	Homo sapiens	176-181
16126913-0	2005	Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane.	Water	37-42	aquaporin 9	Homo sapiens	92-96
16061068-9	2005	Within 15 min after the onset of low-water stress, POMC mRNA expression was elevated 1.87-fold above the control value.	Water	37-42	proopiomelanocortin	Homo sapiens	51-55
16061068-13	2005	We conclude that POMC and cortisol are both involved in the low-water stress response during which cortisol may serve as a negative regulator of POMC expression in catfish.	Water	64-69	proopiomelanocortin	Homo sapiens	17-21
16241447-1	2005	We calculate the phase diagram of amorphous solid water by performing molecular dynamics simulations using the extended simple point charge (SPC/E) model.	Water	50-55	proline rich protein gene cluster	Homo sapiens	141-144
16210785-4	2005	Activity assay of caspases revealed that caspase-3, -8 and -9 were activated 2 h after exposure to H(2)O(2), whereas in irradiated cells caspase-3 and -9 activation occurred 4 h after exposure but increased caspase-8 activation was not observed.	Water	99-104	caspase 3	Homo sapiens	41-61
16241447-13	2005	We do not observe a VHDA --&gt; HDA transformation, and our final phase diagram of glassy water together with equilibrium liquid data suggests that for the SPC/E model the VHDA --&gt; HDA transformation cannot be observed with the present heating rates accessible in simulations.	Water	90-95	proline rich protein gene cluster	Homo sapiens	156-159
16043061-5	2005	The PCA1 and PCA2 are related with the water (or ethanol) content of the sample, whereas the PCA3 is related with the fluorescence background of the Raman spectra.	Water	39-44	prostate cancer associated transcript 2	Homo sapiens	13-17
16142301-1	2005	Angiotensin II, a potent vasoconstrictor, also participates in the regulation of renal sodium and water excretion, not only via a myriad of effects on renal hemodynamics, glomerular filtration rate, and regulation of aldosterone secretion, but also via direct effects on renal tubule transport.	Water	98-103	angiotensinogen	Homo sapiens	0-14
16054191-2	2005	A model to estimate the actual DO profile and the "sedimentary oxygen demand (SOD)" must specify the rate of microbial or chemical activity in the sediment as well as the diffusive supply of DO from the water column through the diffusive boundary layer into the sediment.	Water	203-208	superoxide dismutase 1	Homo sapiens	78-81
16159815-13	2005	The aprotinin group demonstrated decreased myocardial tissue water content (81.2+/-0.5% versus 83.5+/-0.3%; P=0.01) and reduced intravenous fluid requirements (2.9+/-0.2 L versus 4.0+/-0.4 L; P=0.03).	Water	61-66	pancreatic trypsin inhibitor-like	Sus scrofa	4-13
16042464-1	2005	The effect of pH on the adsorption of catalase and lysozyme at the air-water interface has been studied using a combined surface pressure-interfacial shear rheology technique.	Water	71-76	catalase	Homo sapiens	38-46
16097814-0	2005	Novel self-assembled chain of water molecules in a metal-organic framework structure of Co(II) with tartrate acid.	Water	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	120-125	aquaporin 8	Homo sapiens	209-213
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	120-125	aquaporin 9	Homo sapiens	215-219
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	120-125	major intrinsic protein of lens fiber	Homo sapiens	225-229
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	174-179	aquaporin 8	Homo sapiens	209-213
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	174-179	aquaporin 9	Homo sapiens	215-219
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	174-179	major intrinsic protein of lens fiber	Homo sapiens	225-229
16055121-5	2005	Silencing of p38MAPK drastically hindered the elevation in catalase (protein and mRNA) levels observed after a single low dose (50 microM) of H2O.	Water	142-145	mitogen-activated protein kinase 14	Homo sapiens	13-20
16055121-5	2005	Silencing of p38MAPK drastically hindered the elevation in catalase (protein and mRNA) levels observed after a single low dose (50 microM) of H2O.	Water	142-145	catalase	Homo sapiens	59-67
15941721-3	2005	Molecular modeling of the apoAV signal peptide (SP) showed an increased angle of insertion (65 degrees ) at the lipid/water interface of Trp-19 SP compared with Ser-19 SP (40 degrees ), predicting reduced translocation.	Water	118-123	apolipoprotein A5	Homo sapiens	26-31
16852842-1	2005	Second harmonic generation (SHG), a surface specific, nonlinear optical spectroscopy, was used to study the interfacial solvation of a neutral surfactant, p-nitrophenol (PNP), adsorbed to the water/cyclohexane interface in the presence of simple salts at varying salt concentrations.	Water	192-197	purine nucleoside phosphorylase	Homo sapiens	170-173
16852842-7	2005	Additionally, the surface adsorption of PNP to the water/cyclohexane interface was studied to determine the surface distribution of PNP and the conjugate base, p-nitrophenoxide (PNP(-)), for a 10 mM PNP solution.	Water	51-56	purine nucleoside phosphorylase	Homo sapiens	40-43
16229591-4	2005	As the electron density of the 6s orbital populates in a large outer spherical shell far off the gold nucleus, the p orbitals (or sp hybridized lone-pair orbitals) of the water molecules are able to overlap with the outer part of the 6s orbital in the dihydrated gold cation, resulting in the unusual skewed overlap of p-6s-p orbitals (not the atom-to-atom bond overlap).	Water	171-176	S100 calcium binding protein A12	Homo sapiens	319-322
16042464-1	2005	The effect of pH on the adsorption of catalase and lysozyme at the air-water interface has been studied using a combined surface pressure-interfacial shear rheology technique.	Water	71-76	lysozyme	Homo sapiens	51-59
15800049-8	2005	This low value is characteristic of AQP-mediated water transport, whereas the value in control vesicles was 16.4 kcal/mol.	Water	49-54	aquaporin	Drosophila melanogaster	36-39
15800049-1	2005	Aquaporins (AQPs) accelerate the movement of water and other solutes across biological membranes, yet the molecular mechanisms of each AQP"s transport function and the diverse physiological roles played by AQP family members are still being defined.	Water	45-50	aquaporin	Drosophila melanogaster	12-15
15840770-0	2005	COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction.	Water	54-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15800049-1	2005	Aquaporins (AQPs) accelerate the movement of water and other solutes across biological membranes, yet the molecular mechanisms of each AQP"s transport function and the diverse physiological roles played by AQP family members are still being defined.	Water	45-50	aquaporin	Drosophila melanogaster	135-138
15870380-4	2005	Oocytes expressing human (h)OAT1, rat (r)Oat1, and hOAT4 accumulated 6.5-, 7.1-, and 8.9-fold more EA, respectively, than did water-injected oocytes.	Water	126-131	solute carrier family 22 member 11	Homo sapiens	51-56
15996193-0	2005	Salvia miltiorrhiza water-soluble extract, but not its constituent salvianolic acid B, abrogates LPS-induced NF-kappaB signalling in intestinal epithelial cells.	Water	20-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	109-118
15894173-7	2005	Our results indicate that pp60(src) and Btk co-immunoprecipitate after platelet stimulation with TG+Iono, thrombin or H(2)O(2).	Water	118-123	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	31-34
16101434-5	2005	The brain renin-angiotensin system mediates several classic physiological effects including body water balance, maintenance of blood pressure, sexual behaviors, and regulation of pituitary gland hormones.	Water	97-102	renin	Homo sapiens	10-15
15976003-13	2005	In summary, these findings demonstrate that the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the HPS/aBS model.	Water	186-191	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	108-111
16107322-14	2005	CONCLUSIONS: : The protective effects of YGW on CCl(4) hepatotoxicity are due in part to inhibition of KC NF-kappaB activation and TNFalpha expression by small water soluble molecules, and may also be related to suppressed hepatic expression of CYP4A10 and 4A14 that are considered as alternative prooxidant cytochromes.	Water	160-165	tumor necrosis factor	Mus musculus	131-139
16705836-6	2005	Over 32 days of exposure, microbial heterotrophic activity was sensitive to only the interactive effect of HG*ATR*CPF in the sediments and only CPF in the water.	Water	155-160	nuclear receptor subfamily 5 group A member 2	Homo sapiens	144-147
16187580-4	2005	Results are reported here from a study designed to investigate the efficiency of deionized water extraction of aerosol nitrate (NO3-) and sulfate from nylon filters.	Water	91-96	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
16187580-6	2005	Results indicate that the nylon filters provide superior retention of collected fine particle NO3-, relative to Teflon filters, and that deionized water extraction (with ultrasonication) of collected NO3- and sulfate is as efficient, for the situations studied, as extraction using a basic solution of 1.7 mM sodium bicarbonate and 1.8 mM sodium carbonate.	Water	147-152	NBL1, DAN family BMP antagonist	Homo sapiens	200-203
15967736-3	2005	Mutations in the CFTR gene lead to hyperabsorption of sodium chloride and a reduction in the periciliary salt and water content which leads to impaired mucociliary clearance.	Water	114-119	CF transmembrane conductance regulator	Homo sapiens	17-21
16014042-9	2005	Interestingly, in oocytes injected with rBAT with or without xCT, uptake of l-cystine was significantly greater than that in water-injected oocytes.	Water	125-130	solute carrier family 7 member 11	Canis lupus familiaris	61-64
16115460-8	2005	Moreover, water deprivation, while increasing the activity of AVP neurons, reduces plasma apelin concentrations and induces an intra-neuronal pile up of the peptide, thereby decreasing the inhibitory effect of apelin on AVP release and preventing additional water loss at the kidney level.	Water	10-15	arginine vasopressin	Rattus norvegicus	62-65
16115460-8	2005	Moreover, water deprivation, while increasing the activity of AVP neurons, reduces plasma apelin concentrations and induces an intra-neuronal pile up of the peptide, thereby decreasing the inhibitory effect of apelin on AVP release and preventing additional water loss at the kidney level.	Water	10-15	arginine vasopressin	Rattus norvegicus	220-223
16115460-8	2005	Moreover, water deprivation, while increasing the activity of AVP neurons, reduces plasma apelin concentrations and induces an intra-neuronal pile up of the peptide, thereby decreasing the inhibitory effect of apelin on AVP release and preventing additional water loss at the kidney level.	Water	258-263	arginine vasopressin	Rattus norvegicus	62-65
16079071-7	2005	The water-soluble fraction of UPs was sufficient for inducing ERK1/2 and p38 phosphorylation, which was also losartan inhibitable.	Water	4-9	mitogen-activated protein kinase 3	Homo sapiens	62-68
16079071-7	2005	The water-soluble fraction of UPs was sufficient for inducing ERK1/2 and p38 phosphorylation, which was also losartan inhibitable.	Water	4-9	mitogen-activated protein kinase 1	Homo sapiens	73-76
15815585-7	2005	In addition, GET-1 brains exhibited more Evans blue extravasation and showed decreased endothelial occludin expression after MCAO, correlating with higher brain water content and increased cerebral edema.	Water	161-166	grainyhead like transcription factor 3	Mus musculus	13-18
15855355-2	2005	administration of the hexapeptide Ac-RYYRWK-NH(2), a partial agonist of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor, produces a selective water diuresis without marked cardiovascular or behavioral effects.	Water	152-157	prepronociceptin	Homo sapiens	100-105
16152830-5	2005	Tap water was given by gastrogavage to the mice in the control group.	Water	4-9	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	0-3
15982044-0	2005	Surface rheology of PEO-PPO-PEO triblock copolymers at the air-water interface: comparison of spread and adsorbed layers.	Water	63-68	protoporphyrinogen oxidase	Homo sapiens	24-27
15964017-8	2005	Superposition of the SoPIP2;1 potential map with the atomic model of AQP1 demonstrates the generally well conserved overall structure of water channels.	Water	137-142	aquaporin 1 (Colton blood group)	Homo sapiens	69-73
15979170-8	2005	In addition to developmental regulation, the effect of cold stress and water starvation were tested on cystatin expression.	Water	71-76	LOC100857070	Zea mays	103-111
15979170-9	2005	Two genes (CC8 and CC9) were induced by cold stress and 5 genes (CCII, CC3, CC4, CC5 and CC9) were down-regulated in response to water starvation.	Water	129-134	cystatin 8	Zea mays	11-14
15979170-9	2005	Two genes (CC8 and CC9) were induced by cold stress and 5 genes (CCII, CC3, CC4, CC5 and CC9) were down-regulated in response to water starvation.	Water	129-134	putative cystatin	Zea mays	19-22
15979170-9	2005	Two genes (CC8 and CC9) were induced by cold stress and 5 genes (CCII, CC3, CC4, CC5 and CC9) were down-regulated in response to water starvation.	Water	129-134	cystatin 3	Zea mays	71-74
15979170-9	2005	Two genes (CC8 and CC9) were induced by cold stress and 5 genes (CCII, CC3, CC4, CC5 and CC9) were down-regulated in response to water starvation.	Water	129-134	putative cystatin	Zea mays	89-92
15958180-0	2005	Establishment of HEK293 cell line expressing green fluorescent protein-aquaporin-1 to determine osmotic water permeability.	Water	104-109	aquaporin 1 (Colton blood group)	Homo sapiens	71-82
15734879-1	2005	The subfornical organ (SFO), one of the brain circumventricular organs, is known to mediate some of the central effects of angiotensin II related to sodium and water homeostasis.	Water	160-165	angiotensinogen	Rattus norvegicus	123-137
15713911-7	2005	In contrast, there was increased expression of three proteins normally expressed at higher levels in the cortical collecting duct (CCD) than in IMCD: AQP3 (another basolateral water channel) and the epithelial sodium channel subunits beta-ENaC and gamma-ENaC.	Water	176-181	aquaporin 3	Mus musculus	150-154
15958180-2	2005	The present study aimed to establish a cell line stably transfected with AQP1 to measure osmotic water permeability.	Water	97-102	aquaporin 1 (Colton blood group)	Homo sapiens	73-77
15958180-7	2005	The typical AQP1 inhibitor, mercuric chloride, validated this osmotic water permeability assay.	Water	70-75	aquaporin 1 (Colton blood group)	Homo sapiens	12-16
16236006-3	2005	In human peripheral blood mononuclear cells (PBMCs), CA (water extract) and RN (water and ethanol extracts) significantly increased proliferation and the production of IL-2 and TNF-alpha.	Water	57-62	interleukin 2	Homo sapiens	168-172
16236006-3	2005	In human peripheral blood mononuclear cells (PBMCs), CA (water extract) and RN (water and ethanol extracts) significantly increased proliferation and the production of IL-2 and TNF-alpha.	Water	80-85	interleukin 2	Homo sapiens	168-172
16236006-3	2005	In human peripheral blood mononuclear cells (PBMCs), CA (water extract) and RN (water and ethanol extracts) significantly increased proliferation and the production of IL-2 and TNF-alpha.	Water	80-85	tumor necrosis factor	Homo sapiens	177-186
16236006-3	2005	In human peripheral blood mononuclear cells (PBMCs), CA (water extract) and RN (water and ethanol extracts) significantly increased proliferation and the production of IL-2 and TNF-alpha.	Water	57-62	tumor necrosis factor	Homo sapiens	177-186
16029032-3	2005	HSA-Fmoc-insulin is water-soluble and, upon incubation in aqueous buffers reflecting normal human serum conditions, slowly, spontaneously, and homogeneously hydrolyzes to release unmodified insulin with a t 1/2 of 25 +/- 2 h. A single subcutaneous or intraperitoneal administration of HSA-Fmoc-insulin to diabetic rodents lowers circulating glucose levels for about 4 times longer than an equipotent dose of Zn2+-free insulin.	Water	20-25	insulin	Homo sapiens	9-16
16004416-0	2005	Water-soluble complexes through coulombic interactions between bovine serum albumin and anionic polyelectrolytes grafted with hydrophilic nonionic side chains.	Water	0-5	albumin	Homo sapiens	70-83
16247513-10	2005	MGluR5 knockout mice have shown impairments in water maze and radial arm maze performance as well as in contextual fear conditioning, but not in cue conditioning.	Water	47-52	glutamate receptor, metabotropic 5	Mus musculus	0-6
16080698-0	2005	Condensation reaction between angiotensin II and dicarboxylic acid in water at high temperature without any catalytic agent additive.	Water	70-75	angiotensinogen	Homo sapiens	30-44
16080698-1	2005	The condensation reaction of angiotensin II and tartaric acid in water at 100-140 degrees C proceeded without any added catalytic agent.	Water	65-70	angiotensinogen	Homo sapiens	29-43
16041122-0	2005	Angiotensin III as well as angiotensin II regulates water flow through aquaporins in a clam worm.	Water	52-57	angiotensinogen	Homo sapiens	27-41
16041122-7	2005	Since tetrachloroaurate (III) is a representative blocker of aquaporins, these results indicate that angiotensin III as well as angiotensin II regulates water flow through aquaporins in clam worms.	Water	153-158	angiotensinogen	Homo sapiens	101-115
16000537-5	2005	Osmotic water permeability (Pf) of Xenopus oocytes expressing tilapia AQP3 was about 30-fold higher than that of control oocytes, and was 80% inhibited by treatment with 0.3 mmol l(-1) HgCl2.	Water	8-13	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	70-74
16240586-3	2005	The present study investigated the mutagenicity and the reactivity of NOC collected in water samples from the exhausts of diesel and gasoline engines.	Water	87-92	nocturnin	Homo sapiens	70-73
15605414-3	2005	Glutamine- or amino acid-deprivation and hyperosmotic stress induce a fast cell shrinkage (with marked decrease of the intracellular water volume) associated to mTOR-dependent S6K1 dephosphorylation.	Water	133-138	mechanistic target of rapamycin kinase	Homo sapiens	161-165
16080717-4	2005	However, the results of 1 ns molecular dynamics simulations show that carp ovum cystatin exhibits less structural integrity than chicken egg white cystatin in explicit water at 300 K. The relatively hydrophilic Met62 of carp ovum cystatin, corresponding to the hydrophobic Leu68 of human cystatin C and Ile66 of chicken egg white cystatin, may destabilize the hydrophobic core and form a dimeric structure more easily through domain swapping.	Water	168-173	cystatin C	Gallus gallus	80-88
15827107-0	2005	Independent and combined effects of testosterone and growth hormone on extracellular water in hypopituitary men.	Water	85-90	growth hormone 1	Homo sapiens	53-67
15980194-8	2005	Overexpression of beta-1,3-glucanase in the seed-covering layers of transgenic tobacco seeds did not alter the moisture sorption isotherms or the spatial pattern of water uptake during imbibition, but partially reverted the ABA inhibition of phase III water uptake and of endosperm rupture.	Water	252-257	glucan endo-1,3-beta-glucosidase, acidic-like	Nicotiana tabacum	18-36
16880976-1	2005	Water-soluble H-CNFs modified with a carboxyl group possessed the ability to induce TNF-alpha, whereas CHAPS-treated H-CNFs possessed significantly greater activity and were also found to activate NF-kappaB reporter activity, to a significantly greater level than H-CNFs; furthermore the functional group modified or coated on the surface of H-CNFs was a significant cytotoxic factor that affected cell activation.	Water	0-5	tumor necrosis factor	Homo sapiens	84-93
15935952-3	2005	TNF-alpha inhibited net water and chloride absorption, down-regulated in both surface and crypt colonocytes the Na+-K+-2Cl- cotransporter, and reduced the protein expression and activity of the Na+-K+ ATPase.	Water	24-29	tumor necrosis factor	Rattus norvegicus	0-9
16089947-1	2005	We perform molecular dynamics (MD) simulations using the extended simple-point-charge (SPC/E) model for water to study the structural relaxation through the glass transition region.	Water	104-109	proline rich protein gene cluster	Homo sapiens	87-90
16038303-1	2005	The thermodynamic and extra-thermodynamic dependencies of five types of cytochrome c in water-acetonitrile mixtures of different composition in the presence of immobilised n-octyl ligands as a function of temperature from 278 K to 338 K have been investigated.	Water	88-93	cytochrome c, somatic	Homo sapiens	72-84
16035786-8	2005	These charge distributions combined with a dipole polarizability and a Buckingham exp-6 potential are found to play a crucial role for the successful and simultaneous predictions of a variety of water properties.	Water	195-200	exportin 6	Homo sapiens	82-87
15952833-1	2005	The goal of this work was to investigate the dynamics of human plasma fibronectin (HFN) at the oil-water interface and to characterize its interactions with human serum albumin (HSA) by total internal reflection fluorescence microscopy (TIRFM).	Water	99-104	fibronectin 1	Homo sapiens	70-81
15952833-2	2005	Among key results, we observed that fibronectin adsorption at the oil-water interface is rapid and essentially irreversible, even over short time scales.	Water	70-75	fibronectin 1	Homo sapiens	36-47
15917194-10	2005	This study suggests that water-soluble antioxidants, which scavenge superoxide radicals, may reduce platelet CD40L expression.	Water	25-30	CD40 ligand	Homo sapiens	109-114
15934728-5	2005	(18)O isotope tracing shows that H(2)O is the source of oxygen transferred to PPh(3).	Water	33-38	caveolin 1	Homo sapiens	78-84
16008432-4	2005	The resulting Langevin equation describing QHD-2 coupled to classical bath is analyzed and applied to free particle, harmonic oscillator, and the Morse potential representing the OH stretch of the SPC-flexible water model.	Water	210-215	proline rich protein gene cluster	Homo sapiens	197-200
16008466-0	2005	A potential model for the study of ices and amorphous water: TIP4P/Ice.	Water	54-59	carboxylesterase 2	Homo sapiens	61-70
16852340-2	2005	We show in detail how the spanning (percolating) water network appears at the surfaces of model hydrophilic spheres and at the surface of a single protein (lysozyme) molecule.	Water	49-54	lysozyme	Homo sapiens	156-164
15650123-9	2005	The results of this study demonstrate that serum S100beta was elevated after water immersion and prolonged exercise in a warm environment, suggesting that blood-brain barrier permeability may be altered.	Water	77-82	S100 calcium binding protein B	Homo sapiens	49-57
16833817-6	2005	As a check on this conclusion, we have measured the rate of the SN1 decomposition of benzene diazonium tetrafluoroborate in 2-butoxyethanol + water near the lower critical solution temperature and also the rate of the acid-catalyzed decomposition of ethyl diazoacetate in isobutyric acid + water near the upper critical solution temperature.	Water	142-147	solute carrier family 38 member 3	Homo sapiens	64-67
16833817-6	2005	As a check on this conclusion, we have measured the rate of the SN1 decomposition of benzene diazonium tetrafluoroborate in 2-butoxyethanol + water near the lower critical solution temperature and also the rate of the acid-catalyzed decomposition of ethyl diazoacetate in isobutyric acid + water near the upper critical solution temperature.	Water	290-295	solute carrier family 38 member 3	Homo sapiens	64-67
15644488-1	2005	Vasopressin-stimulated insertion of the aquaporin 2 (AQP2) water channel into the plasma membrane of kidney collecting duct principal cells is a key event in the urinary concentrating mechanism.	Water	59-64	arginine vasopressin	Rattus norvegicus	0-11
15901245-1	2005	Following the discovery of the aquaporin-1 water channel over a decade ago, molecular techniques have been developed to examine the role of renal aquaporin water channels under numerous physiological and pathological conditions.	Water	43-48	aquaporin 1 (Colton blood group)	Homo sapiens	31-42
15687250-1	2005	Arginine vasopressin (AVP), acting through a cAMP second messenger system, regulates osmotic water permeability (Pf) of the collecting duct.	Water	93-98	arginine vasopressin	Rattus norvegicus	9-20
16075377-9	2005	Classical, well-defined actions of Angiotensin II in the brain include the regulation of hormone formation and release, the control of the central and peripheral sympathoadrenal systems, and the regulation of water and sodium intake.	Water	209-214	angiotensinogen	Rattus norvegicus	35-49
15893443-4	2005	Then molecular mechanisms of vasopressin free water retention through acquaporin water channels in collecting duct cells are discussed: further studies are necessary to understand vasopressin release pathway (osmotic/nonosmotic) and V2 receptor activation with cell surface expression of renal acquaporins water channel.	Water	46-51	arginine vasopressin	Homo sapiens	29-40
15893443-4	2005	Then molecular mechanisms of vasopressin free water retention through acquaporin water channels in collecting duct cells are discussed: further studies are necessary to understand vasopressin release pathway (osmotic/nonosmotic) and V2 receptor activation with cell surface expression of renal acquaporins water channel.	Water	81-86	arginine vasopressin	Homo sapiens	29-40
15893443-4	2005	Then molecular mechanisms of vasopressin free water retention through acquaporin water channels in collecting duct cells are discussed: further studies are necessary to understand vasopressin release pathway (osmotic/nonosmotic) and V2 receptor activation with cell surface expression of renal acquaporins water channel.	Water	81-86	arginine vasopressin	Homo sapiens	29-40
15309420-14	2005	Plasma FRAP and alpha-tocopherol also decreased slightly, but not significantly, after intake of water.	Water	97-102	mechanistic target of rapamycin kinase	Homo sapiens	7-11
15784718-9	2005	GH significantly increased total body weight (P = 0.028), an effect predominantly ascribed to fluid retention (increased extracellular water volume), whereas muscle mass (as indicated by intracellular water volume) did not change.	Water	135-140	growth hormone 1	Homo sapiens	0-2
15797955-5	2005	Obese insulin-sensitive subjects had lower intramyocellular (1.64 +/- 0.68 vs.2.26 +/- 0.62% of water peak, P = 0.017) and visceral lipid deposition (45 +/- 23 vs. 77 +/- 52 cm(2), P = 0.04) and a higher level of adiponectin, compared with their obese-resistant counterparts (8.8 +/- 3.6 vs. 6.5 +/- 1.8 mug/dl, P = 0.015).	Water	96-101	insulin	Homo sapiens	6-13
15917086-2	2005	The non-heme iron in the enzyme (Fe(III) as isolated) is 6-coordinated to a 2-His-1-carboxylate motif and three water molecules (wat1, wat2 and wat3).	Water	112-117	MTOR associated protein, LST8 homolog	Homo sapiens	129-133
15870910-2	2005	MCH was recently reported to stimulate water intake independent of food intake.	Water	39-44	pro-melanin concentrating hormone	Homo sapiens	0-3
15870910-4	2005	Our results showed that intracerebroventricular injection of MCH acutely increased food as well as water intake.	Water	99-104	pro-melanin concentrating hormone	Homo sapiens	61-64
15917086-3	2005	Tyr325 is at the second coordination sphere, hydrogen-bonded to water (wat1).	Water	64-69	MTOR associated protein, LST8 homolog	Homo sapiens	71-75
15870910-5	2005	Human (h)MCH and salmon (s)MCH increased water intake independent of food intake, which was not suppressed by angiotensin antagonists.	Water	41-46	pro-melanin concentrating hormone	Homo sapiens	9-12
15870910-5	2005	Human (h)MCH and salmon (s)MCH increased water intake independent of food intake, which was not suppressed by angiotensin antagonists.	Water	41-46	pro-melanin concentrating hormone	Homo sapiens	27-30
16089741-1	2005	We investigate structural order in glassy water by performing classical molecular dynamics simulations using the extended simple point charge (SPC/E) model of water.	Water	159-164	proline rich protein gene cluster	Homo sapiens	143-146
15910548-0	2005	Role of water-soluble amyloid-beta in the pathogenesis of Alzheimer"s disease.	Water	8-13	amyloid beta precursor protein	Homo sapiens	22-34
15910548-1	2005	Water-soluble amyloid-beta (wsAbeta) is present in cerebral cortex of subjects at risk of Alzheimer"s disease (AD) as well as in normal elderly subjects as a mixture of three major amyloid-beta (Abeta) species: 1-42, py3-42 and py11-42.	Water	0-5	amyloid beta precursor protein	Homo sapiens	14-26
15910548-1	2005	Water-soluble amyloid-beta (wsAbeta) is present in cerebral cortex of subjects at risk of Alzheimer"s disease (AD) as well as in normal elderly subjects as a mixture of three major amyloid-beta (Abeta) species: 1-42, py3-42 and py11-42.	Water	0-5	amyloid beta precursor protein	Homo sapiens	30-35
16158706-8	2005	Patients with II and III stage essential hypertension responds to the physiological water stress (in contrast to patients with I stage essential hypertension and patients of the control group) with progressive increase in water reabsorption in ducts apparatus of kidneys, decrease in sodium excretion comes along with high level of aldosterone, vasopressin and atrial sodium-releasing hormones.	Water	84-89	arginine vasopressin	Homo sapiens	345-356
19791416-1	2005	We present a hole burning study on insulin in a glycerol-water solvent by using the intrinsic amino acid tyrosine as a photochemical probe.	Water	57-62	insulin	Homo sapiens	35-42
15909995-6	2005	When deprotonated Asp40 (Asp4-COO-) is present, the active site is open to water solvent which interferes with the base stacking between Trp83 and nucleobase.	Water	75-80	napsin A aspartic peptidase	Homo sapiens	18-22
15945757-12	2005	TIP4P and SPC/E have almost identical structures, dissimilar to any known water or amorphous phases, but upon heating both slowly evolve towards LDA-like structure.	Water	74-79	proline rich protein gene cluster	Homo sapiens	10-13
15922018-2	2005	FMO, like cytochrome P450 (CYP), is a monooxygenase, utilizing the reducing equivalents of NADPH to reduce 1 atom of molecular oxygen to water, while the other atom is used to oxidize the substrate.	Water	137-142	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	10-25
15922018-2	2005	FMO, like cytochrome P450 (CYP), is a monooxygenase, utilizing the reducing equivalents of NADPH to reduce 1 atom of molecular oxygen to water, while the other atom is used to oxidize the substrate.	Water	137-142	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	27-30
19791416-2	2005	The focus of the experiments is on the comparative pressure response of the spectral holes for insulin in its native state, in its chemically denatured state and for tyrosine in the glycerol-water solvent.	Water	191-196	insulin	Homo sapiens	95-102
15755725-4	2005	In this study, we hypothesized that IL-1beta would decrease vectorial ion and water transport across the distal lung epithelium.	Water	78-83	interleukin 1 beta	Homo sapiens	36-44
15850555-4	2005	In the presence of 50 microM H(2)O(2), arrest was observed in the G2-phase of the cell cycle, along with p53-independent apoptosis.	Water	29-34	tumor protein p53	Homo sapiens	105-108
15869255-1	2005	The (bis)dansylated sulfonamide 1,2-C6H4(NHSO2C10H6-5-N(CH3)2)2 (1) extracted Pb(II) selectively from water into 1,2-dichloroethane via an ion-exchange mechanism and showed fluorescence quenching upon Pb(II) extraction.	Water	102-107	submaxillary gland androgen regulated protein 3B	Homo sapiens	78-84
15869255-1	2005	The (bis)dansylated sulfonamide 1,2-C6H4(NHSO2C10H6-5-N(CH3)2)2 (1) extracted Pb(II) selectively from water into 1,2-dichloroethane via an ion-exchange mechanism and showed fluorescence quenching upon Pb(II) extraction.	Water	102-107	submaxillary gland androgen regulated protein 3B	Homo sapiens	201-207
16833735-5	2005	The valence bands of the (100) surfaces of both MgSO(4) and MgSO(4).H(2)O are formed mainly by the O2p levels, whereas the S2p states contribute to the lower part of the conduction band.	Water	68-73	ribosomal protein S2	Homo sapiens	123-126
15852127-2	2005	The single crystal X-ray crystallographic analysis performed on species exemplifies that it is built by 2D [Cu3(mu-OH)2(mu-Cl)2(mu-2-pymo)(mu-4,4"-bpy)3]n(n+) cationic sheets, which pack in a staggered fashion, with non coordinated NO3- anions and crystallisation water molecules included in the interlayer voids.	Water	264-269	NBL1, DAN family BMP antagonist	Homo sapiens	232-235
15847852-6	2005	AVP regulates vascular tone and free-water reabsorption, respectively, through the vasopressin V(1a) and V(2) receptor subtypes and therefore is a potential neurohormonal target in the treatment of CHF.	Water	37-42	arginine vasopressin	Homo sapiens	0-3
15837305-0	2005	Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.	Water	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
15837305-1	2005	Interest in water soluble COX-2 inhibitors that can be administered intravenously led to the development of novel pro-drugs of a furanone based COX-2 inhibitor 2.	Water	12-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
15837305-1	2005	Interest in water soluble COX-2 inhibitors that can be administered intravenously led to the development of novel pro-drugs of a furanone based COX-2 inhibitor 2.	Water	12-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
15776447-6	2005	Fourth ventricular orexin injections also significantly stimulated chow and water intake in nonfood-deprived rats.	Water	76-81	hypocretin neuropeptide precursor	Rattus norvegicus	19-25
15847422-3	2005	When La(NO3)3 x 7H2O is used in place of LaCl3 x 6H2O, a similar structure is formed with the empirical formula, [La(pdc)(H2O)4] x NO3 (2), where water molecules and the nitrate anions occupy the voids as in the case of 1.	Water	146-151	NBL1, DAN family BMP antagonist	Homo sapiens	8-11
15847422-3	2005	When La(NO3)3 x 7H2O is used in place of LaCl3 x 6H2O, a similar structure is formed with the empirical formula, [La(pdc)(H2O)4] x NO3 (2), where water molecules and the nitrate anions occupy the voids as in the case of 1.	Water	146-151	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
15890005-6	2005	c-Abl and Arg nonreceptor protein tyrosine kinases associate with catalase in cells treated with H(2)O(2) by mechanisms involving the SH3 domains of the kinases and the Pro(293)PheAsnPro motif of catalase and activate catalase by phosphorylating it on Tyr(231) and Tyr(386).	Water	97-102	catalase	Homo sapiens	66-74
15830191-7	2005	The method was applied for the determination of TNT in water and soil spiked samples; recoveries were higher than 95% in all cases.	Water	55-60	chromosome 16 open reading frame 82	Homo sapiens	48-51
15858274-0	2005	Water molecules in the antibody-antigen interface of the structure of the Fab HyHEL-5-lysozyme complex at 1.7 A resolution: comparison with results from isothermal titration calorimetry.	Water	0-5	lysozyme	Homo sapiens	86-94
15858274-5	2005	The refined structure has yielded a detailed picture of the Fab-lysozyme interface, showing the high complementarity of the protein surfaces as well as several water molecules within the interface that complete the good fit.	Water	160-165	lysozyme	Homo sapiens	64-72
15647389-1	2005	Aquaporin-8 (AQP8) is a water-transporting protein expressed in organs of the mammalian gastrointestinal tract (salivary gland, liver, pancreas, small intestine, and colon) and in the testes, heart, kidney, and airways.	Water	24-29	aquaporin 8	Homo sapiens	0-11
15647389-1	2005	Aquaporin-8 (AQP8) is a water-transporting protein expressed in organs of the mammalian gastrointestinal tract (salivary gland, liver, pancreas, small intestine, and colon) and in the testes, heart, kidney, and airways.	Water	24-29	aquaporin 8	Homo sapiens	13-17
15890029-1	2005	Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water.	Water	161-166	cystathionine beta-synthase	Homo sapiens	0-27
15890005-6	2005	c-Abl and Arg nonreceptor protein tyrosine kinases associate with catalase in cells treated with H(2)O(2) by mechanisms involving the SH3 domains of the kinases and the Pro(293)PheAsnPro motif of catalase and activate catalase by phosphorylating it on Tyr(231) and Tyr(386).	Water	97-102	catalase	Homo sapiens	196-204
15890029-1	2005	Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water.	Water	161-166	cystathionine beta-synthase	Homo sapiens	29-32
15890005-6	2005	c-Abl and Arg nonreceptor protein tyrosine kinases associate with catalase in cells treated with H(2)O(2) by mechanisms involving the SH3 domains of the kinases and the Pro(293)PheAsnPro motif of catalase and activate catalase by phosphorylating it on Tyr(231) and Tyr(386).	Water	97-102	catalase	Homo sapiens	196-204
15885091-5	2005	Establishing by electrochemical methods the endogenous production H(2)O(2) in real time confirms recent reports, based in large part on the use of exogenous H(2)O(2), that tyrosinase can manifest both catalase and peroxidase activities.	Water	66-71	catalase	Homo sapiens	201-209
15917962-0	2005	Dialysis water treated by reverse osmosis decreases the levels of C-reactive protein in uremic patients.	Water	9-14	C-reactive protein	Homo sapiens	66-84
15917962-10	2005	From the 23 remaining patients (mean age +/- SD: 51.3 +/- 13.9 years), 18 had a decrease in CRP after the water treatment system was changed.	Water	106-111	C-reactive protein	Homo sapiens	92-95
15917962-13	2005	In conclusion, uremic patients presented a clinically significant reduction in CRP levels when dialysate water purification system switched from deionization to reverse osmosis.	Water	105-110	C-reactive protein	Homo sapiens	79-82
15948635-8	2005	A significant increase in plasma AVP level was observed after water deprivation and simultaneous water and food deprivation, while no change was found after food deprivation.	Water	62-67	arginine vasopressin	Rattus norvegicus	33-36
15645307-2	2005	Model surfactant films composed of lipids and SP-C display a reversible transition from a monolayer to surface-associated multilayers upon compression and expansion at the air/water (A/W) interface.	Water	176-181	surfactant protein C	Homo sapiens	46-50
15769624-7	2005	cGKII is involved in intestinal water secretion, bone growth and circardian rhythmicity.	Water	32-37	protein kinase, cGMP-dependent, type II	Mus musculus	0-5
15576151-1	2005	Functionalized dextrans (FD) are anionic water-soluble polymers bearing carboxylate, benzylamide and sulfate groups, which exhibit binding capacity to transforming growth factor-beta1 (TGF-beta1).	Water	41-46	transforming growth factor beta 1	Homo sapiens	151-183
15576151-1	2005	Functionalized dextrans (FD) are anionic water-soluble polymers bearing carboxylate, benzylamide and sulfate groups, which exhibit binding capacity to transforming growth factor-beta1 (TGF-beta1).	Water	41-46	transforming growth factor beta 1	Homo sapiens	185-194
15921452-2	2005	Different strategies for the in silico generation of ligand molecules in the binding site of poly(ADP-ribose)polymerase (PARP) were studied in order to observe the effect of the targeting and displacement of tightly bound water molecules.	Water	222-227	poly(ADP-ribose) polymerase 1	Homo sapiens	121-125
15809704-0	2005	Heterogeneous expression of the aquaporin 1 (AQP1) water channel in tumors of the prostate, breast, ovary, colon and lung: a study using high density multiple human tumor tissue microarrays.	Water	51-56	aquaporin 1 (Colton blood group)	Homo sapiens	32-43
15809704-0	2005	Heterogeneous expression of the aquaporin 1 (AQP1) water channel in tumors of the prostate, breast, ovary, colon and lung: a study using high density multiple human tumor tissue microarrays.	Water	51-56	aquaporin 1 (Colton blood group)	Homo sapiens	45-49
15809704-1	2005	Aquaporin 1 (AQP1) water channels are membrane proteins that control the permeability of endothelial and epithelial barriers by facilitating water movement across cell membranes.	Water	19-24	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
15809704-1	2005	Aquaporin 1 (AQP1) water channels are membrane proteins that control the permeability of endothelial and epithelial barriers by facilitating water movement across cell membranes.	Water	19-24	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
15809704-1	2005	Aquaporin 1 (AQP1) water channels are membrane proteins that control the permeability of endothelial and epithelial barriers by facilitating water movement across cell membranes.	Water	141-146	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
15809704-1	2005	Aquaporin 1 (AQP1) water channels are membrane proteins that control the permeability of endothelial and epithelial barriers by facilitating water movement across cell membranes.	Water	141-146	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
15809704-9	2005	In conclusion, the AQP1 water channel is an excellent marker of microvasculature but it is heterogeneously expressed in different human tumors and not necessarily expressed in all neoplastic cells.	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	19-23
26641504-2	2005	While the tertiary dimer structure is modulated by the hydrophobic lipid bilayer environment, we show that interactions of GpA with ordered interfacial water are commensurate to intrahelical forces.	Water	152-157	glycophorin A (MNS blood group)	Homo sapiens	123-126
26641504-5	2005	To quantify forces capable of disrupting the GpA dimer, we generate folding/unfolding intermediates by replacement of the lipid bilayer with water, eliminating not only the native hydrophobic environment but also the native interfacial water region.	Water	141-146	glycophorin A (MNS blood group)	Homo sapiens	45-48
26641504-5	2005	To quantify forces capable of disrupting the GpA dimer, we generate folding/unfolding intermediates by replacement of the lipid bilayer with water, eliminating not only the native hydrophobic environment but also the native interfacial water region.	Water	236-241	glycophorin A (MNS blood group)	Homo sapiens	45-48
15840783-4	2005	The phenol-water extracts activated human gingival fibroblasts to mediate IL-8 production, as well as IL-8 mRNA expression, phosphorylation of p38 mitogen-activated protein kinase, and expression of intercellular adhesion molecule-1.	Water	11-16	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15840783-4	2005	The phenol-water extracts activated human gingival fibroblasts to mediate IL-8 production, as well as IL-8 mRNA expression, phosphorylation of p38 mitogen-activated protein kinase, and expression of intercellular adhesion molecule-1.	Water	11-16	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
15840783-4	2005	The phenol-water extracts activated human gingival fibroblasts to mediate IL-8 production, as well as IL-8 mRNA expression, phosphorylation of p38 mitogen-activated protein kinase, and expression of intercellular adhesion molecule-1.	Water	11-16	mitogen-activated protein kinase 14	Homo sapiens	143-179
16010942-4	2005	The photo-catalytic oxidation of methanol, at concentrations of 0.1 to 1.1 mol% in air, gave rise to formation of CO2 and H2O as products, for both the TiO2/MCM and bulk TiO2 samples.	Water	122-125	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	157-160
15891494-14	2005	CONCLUSIONS: The higher ADC values in children with NF1 suggest an increase in water content of the normal-appearing brain.	Water	79-84	neurofibromin 1	Homo sapiens	52-55
15870622-13	2005	CONCLUSION: This study has confirmed that selective and nonselective COX inhibition can induce significant inhibition of free water clearance, indicating that these acute changes are regulated predominantly via COX-2.	Water	126-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
15840033-2	2005	Although the expressional alteration of the kidney-specific apical water channel, aquaporin 2 (AQP2), in the collecting duct has been demonstrated to be involved in the development of hyponatremia and the subsequent physiologic reaction that is resistant to arginine vasopressin (AVP; vasopressin escape) in SIADH, the complete pathogenesis of and the appropriate medical treatment for hyponatremia have yet to be elucidated.	Water	67-72	arginine vasopressin	Rattus norvegicus	285-296
15840033-2	2005	Although the expressional alteration of the kidney-specific apical water channel, aquaporin 2 (AQP2), in the collecting duct has been demonstrated to be involved in the development of hyponatremia and the subsequent physiologic reaction that is resistant to arginine vasopressin (AVP; vasopressin escape) in SIADH, the complete pathogenesis of and the appropriate medical treatment for hyponatremia have yet to be elucidated.	Water	67-72	arginine vasopressin	Rattus norvegicus	267-278
15863571-2	2005	However, when recognized early and treatment is initiated with desmopressin acetate, an analog of vasopressin that is resistant to vasopressinase, water loss in the urine is eliminated and complications may be abrogated.	Water	147-152	arginine vasopressin	Homo sapiens	98-109
15867058-2	2005	The history that a child climbed into a tub previously filled with hot water by the parent is common.	Water	71-76	TUB bipartite transcription factor	Homo sapiens	40-43
15749715-6	2005	The osmotic water transport of liver IMM was partially inhibited by the aquaporin blocker Hg2+, while the related activation energy remained low, suggesting the presence of a Hg2+-insensitive facilitated pathway in addition to AQP8.	Water	12-17	aquaporin 8	Rattus norvegicus	227-231
15749715-7	2005	It is suggested that AQP8-mediated water transport may be particularly important for rapid expansions of mitochondrial volume such as those occurring during active oxidative phosphorylation and those following apoptotic signals.	Water	35-40	aquaporin 8	Rattus norvegicus	21-25
15705590-7	2005	This study is the first demonstration that PLD2 activation is implicated in Src-dependent phosphorylation of Pyk2 (Tyr(580) and Tyr(881)) by promoting the complex formation between Pyk2 and activated Src in PC12 cells exposed to H(2)O(2), thereby resulting in activation of the survival signaling pathway PI3K/Akt/p70S6K.	Water	229-234	protein tyrosine kinase 2 beta	Rattus norvegicus	109-113
15705590-7	2005	This study is the first demonstration that PLD2 activation is implicated in Src-dependent phosphorylation of Pyk2 (Tyr(580) and Tyr(881)) by promoting the complex formation between Pyk2 and activated Src in PC12 cells exposed to H(2)O(2), thereby resulting in activation of the survival signaling pathway PI3K/Akt/p70S6K.	Water	229-234	protein tyrosine kinase 2 beta	Rattus norvegicus	181-185
16833683-7	2005	This provides a framework to interpret the differences observed in the TR3 spectral and triplet lifetime obtained in the neat MeCN solvent (attributed to the free MAP triplet state) and the 50% H2O/50% MeCN solvent (due to the triplet of the hydrogen-bond complex).	Water	194-197	nuclear receptor subfamily 4 group A member 1	Homo sapiens	71-74
15848200-6	2005	Co-stimulation with H(2)O(2) and OAG did not increase ROS generation as compared to OAG alone suggesting both agonists signal through a shared, rate-limited enzymatic pathway involving PLA(2).	Water	20-25	phospholipase A2 group IB	Homo sapiens	185-191
15780284-1	2005	Water-based protein-surfactant gels, formed by mixing bovine serum albumin (BSA) and sodium dodecyl sulfate in water, were investigated by rheological methods.	Water	0-5	albumin	Homo sapiens	61-74
15826202-1	2005	Three series of cobalt(III) corroles were tested as catalysts for the electroreduction of dioxygen to water.	Water	102-107	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	23-26
15826202-6	2005	The cobalt(III) monocorrole (Me(4)Ph(5)Cor)Co also catalyzes the electroreduction of dioxygen at E(1/2) = 0.38 V with the final products being an approximate 50% mixture of H(2)O(2) and H(2)O.	Water	173-178	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	11-14
15826202-6	2005	The cobalt(III) monocorrole (Me(4)Ph(5)Cor)Co also catalyzes the electroreduction of dioxygen at E(1/2) = 0.38 V with the final products being an approximate 50% mixture of H(2)O(2) and H(2)O.	Water	186-191	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	11-14
16851733-2	2005	The intermolecular potentials were modified by increasing the weight of the Lennard-Jones term relative to the electrostatic term in the SPC/E model for water.	Water	153-158	proline rich protein gene cluster	Homo sapiens	137-140
15769471-2	2005	The crystal structure of rhodopsin has previously revealed that Glu122 and Trp126 on transmembrane helix H3 form a complex hydrogen bonding network with Tyr206 and His211 on H5, while the indole nitrogen of Trp265 on H6 forms a water-mediated hydrogen bond with Asn302 on H7.	Water	228-233	rhodopsin	Homo sapiens	25-34
15710610-1	2005	Calmodulin plays a critical role in regulation of renal collecting duct water permeability by vasopressin.	Water	72-77	arginine vasopressin	Rattus norvegicus	94-105
15561974-8	2005	Water deprivation in rats increased EphA2 expression in renal papilla, whereas dietary supplementation with 20% urea increased EphA2 expression in outer medulla.	Water	0-5	Eph receptor A2	Rattus norvegicus	36-41
15585668-0	2005	Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats.	Water	67-72	arginine vasopressin	Rattus norvegicus	47-58
15585668-1	2005	Vasopressin and ANG II, which are known to play a major role in renal water and sodium reabsorption, are mainly coupled to the cAMP/PKA and phosphoinositide pathways, respectively.	Water	70-75	arginine vasopressin	Rattus norvegicus	0-11
15585668-1	2005	Vasopressin and ANG II, which are known to play a major role in renal water and sodium reabsorption, are mainly coupled to the cAMP/PKA and phosphoinositide pathways, respectively.	Water	70-75	angiotensinogen	Rattus norvegicus	16-22
15585668-3	2005	We therefore hypothesized that vasopressin-induced water reabsorption could be attenuated by ANG II AT(1) receptor blockade in rats.	Water	51-56	arginine vasopressin	Rattus norvegicus	31-42
15585668-3	2005	We therefore hypothesized that vasopressin-induced water reabsorption could be attenuated by ANG II AT(1) receptor blockade in rats.	Water	51-56	angiotensinogen	Rattus norvegicus	93-99
15613619-3	2005	Regulated cyclooxygenase-2 (COX-2) in the MD represents another intrinsic system mediating renal salt and water homeostasis.	Water	106-111	prostaglandin-endoperoxide synthase 2	Homo sapiens	10-26
15613619-3	2005	Regulated cyclooxygenase-2 (COX-2) in the MD represents another intrinsic system mediating renal salt and water homeostasis.	Water	106-111	prostaglandin-endoperoxide synthase 2	Homo sapiens	28-33
15827721-1	2005	Simultaneous determination of the fat-soluble vitamins A and E and the water-soluble vitamins B1, B2 and B6 has been carried using a screening method from fluorescence contour graphs.	Water	71-76	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	94-107
15536172-3	2005	Previous studies in the toad urinary bladder, a functional homologue of the renal collecting duct, have demonstrated that the sulfhydryl reagent N-ethylmaleimide (NEM) is also able to activate the vasopressin-sensitive water permeability pathway in this tissue.	Water	219-224	arginine vasopressin	Homo sapiens	197-208
15536172-1	2005	The antidiuretic hormone arginine vasopressin increases the osmotic water permeability of the renal collecting ducts by inducing the shuttling of aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical plasma membrane of the principal cells.	Water	68-73	arginine vasopressin	Homo sapiens	34-45
15536172-1	2005	The antidiuretic hormone arginine vasopressin increases the osmotic water permeability of the renal collecting ducts by inducing the shuttling of aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical plasma membrane of the principal cells.	Water	165-170	arginine vasopressin	Homo sapiens	34-45
15601620-2	2005	Apelin signalling plays a role in the central and peripheral regulation of the cardiovascular system, in water and food intake, and possibly in immune function.	Water	105-110	apelin	Homo sapiens	0-6
15807876-4	2005	RESULTS: In the pooled group with active GH treatment (n = 20) the results showed significant increases: IGF-I increased by 134% (baseline vs. after 1 month), body weight by 2.7%, fat free mass by 5.3%, total body water by 6.5% and extracellular water (ECW) by 9.6%.	Water	214-219	insulin like growth factor 1	Homo sapiens	105-110
15807876-4	2005	RESULTS: In the pooled group with active GH treatment (n = 20) the results showed significant increases: IGF-I increased by 134% (baseline vs. after 1 month), body weight by 2.7%, fat free mass by 5.3%, total body water by 6.5% and extracellular water (ECW) by 9.6%.	Water	246-251	insulin like growth factor 1	Homo sapiens	105-110
15871240-7	2005	Roots deliver oxygen, which oxidizes lead-bearing solid phases and releases Pb(II) to the sediment pore water.	Water	104-109	submaxillary gland androgen regulated protein 3B	Homo sapiens	76-82
15816154-3	2005	Among bathers, patients with meningitis spent more time in the water (mOR 18.8, 95% CI 2.0-174.1) and swallowed water more frequently (mOR = 7.3, 95% CI 0.7-81.8).	Water	112-117	opioid receptor, mu 1	Mus musculus	135-138
15790907-1	2005	PURPOSE: To examine Ca(2+)- and pH-mediated regulation of water permeability of endogenously expressed aquaporin (AQP)0 in lens fiber cells and AQP1 in lens epithelial cells.	Water	58-63	major intrinsic protein of lens fiber	Homo sapiens	114-119
15699473-7	2005	Compared with control animals, transgenic overexpression of neuropeptide Y significantly ameliorated (by 9.7+/-1.5 mm Hg) NO deficiency hypertension (induced by administration of N(omega)-nitro-L-arginine methyl ester in the drinking water).	Water	234-239	neuropeptide Y	Rattus norvegicus	60-74
15790907-5	2005	RESULTS: In the lens or in oocytes, decreasing external pH from 7.5 to 6.5 caused a two- to fourfold increase in the water permeability of mammalian AQP0.	Water	117-122	major intrinsic protein of lens fiber	Homo sapiens	149-153
15790907-3	2005	Osmotic shrinking or swelling of these vesicles was used to determine the water permeability of endogenously expressed AQP0.	Water	74-79	major intrinsic protein of lens fiber	Homo sapiens	119-123
15790907-8	2005	Increasing Ca(2+) caused a two- to fourfold increase in the water permeability of endogenous AQP0.	Water	60-65	major intrinsic protein of lens fiber	Homo sapiens	93-97
15790907-14	2005	However, in the lens, Ca(2+) and H(+) are both increased in inner fiber cells, and so in the physiologically relevant environment, both may act to increase the water permeability of AQP0.	Water	160-165	major intrinsic protein of lens fiber	Homo sapiens	182-186
16233812-4	2005	From circular dichroism analysis of SOD in the presence of H(2)O(2), the contents of the alpha-helix in SOD were found to decrease in correspondence with the inactivation and conformational change of SOD, suggesting that the conformation of the alpha-helix loops affects SOD activity.	Water	59-64	superoxide dismutase 1	Homo sapiens	36-39
16233812-4	2005	From circular dichroism analysis of SOD in the presence of H(2)O(2), the contents of the alpha-helix in SOD were found to decrease in correspondence with the inactivation and conformational change of SOD, suggesting that the conformation of the alpha-helix loops affects SOD activity.	Water	59-64	superoxide dismutase 1	Homo sapiens	104-107
16233812-4	2005	From circular dichroism analysis of SOD in the presence of H(2)O(2), the contents of the alpha-helix in SOD were found to decrease in correspondence with the inactivation and conformational change of SOD, suggesting that the conformation of the alpha-helix loops affects SOD activity.	Water	59-64	superoxide dismutase 1	Homo sapiens	104-107
16233812-4	2005	From circular dichroism analysis of SOD in the presence of H(2)O(2), the contents of the alpha-helix in SOD were found to decrease in correspondence with the inactivation and conformational change of SOD, suggesting that the conformation of the alpha-helix loops affects SOD activity.	Water	59-64	superoxide dismutase 1	Homo sapiens	104-107
15635657-5	2005	The primary hydrophobic interactions with the micelle are from the leucine and phenylalanine residues (Leu-7, Phe-8, Leu-9, Phe-11, Leu-12) while the alanine and glycine residues (Ala-1, Gly-3, Gly-5, Ala-6, Gly-10, Gly-13, Ala-14, Ala-15, Gly-16, Gly-10, Ala-21) interact favorably with water molecules.	Water	288-293	beta-1,3-glucuronyltransferase 1	Homo sapiens	103-108
16245033-0	2005	Botulinum toxins inhibit the antidiuretic hormone (ADH)-stimulated increase in rabbit cortical collecting-tubule water Permeability.	Water	113-118	arginine vasopressin	Homo sapiens	29-49
16245033-0	2005	Botulinum toxins inhibit the antidiuretic hormone (ADH)-stimulated increase in rabbit cortical collecting-tubule water Permeability.	Water	113-118	arginine vasopressin	Homo sapiens	51-54
16245033-1	2005	The mammalian renal collecting duct increases its water permeability in response to antidiuretic hormone (ADH).	Water	50-55	arginine vasopressin	Homo sapiens	84-104
16245033-1	2005	The mammalian renal collecting duct increases its water permeability in response to antidiuretic hormone (ADH).	Water	50-55	arginine vasopressin	Homo sapiens	106-109
16245033-2	2005	ADH causes cytoplasmic endosomes containing the water channel, aquaporin 2 (AQP 2), to fuse with the apical membrane so that the water permeability of the tubule increases many times above baseline.	Water	48-53	arginine vasopressin	Homo sapiens	0-3
16245033-2	2005	ADH causes cytoplasmic endosomes containing the water channel, aquaporin 2 (AQP 2), to fuse with the apical membrane so that the water permeability of the tubule increases many times above baseline.	Water	48-53	aquaporin-2	Oryctolagus cuniculus	76-81
16245033-2	2005	ADH causes cytoplasmic endosomes containing the water channel, aquaporin 2 (AQP 2), to fuse with the apical membrane so that the water permeability of the tubule increases many times above baseline.	Water	129-134	arginine vasopressin	Homo sapiens	0-3
16245033-2	2005	ADH causes cytoplasmic endosomes containing the water channel, aquaporin 2 (AQP 2), to fuse with the apical membrane so that the water permeability of the tubule increases many times above baseline.	Water	129-134	aquaporin-2	Oryctolagus cuniculus	76-81
16245033-7	2005	ADH (200 pM) was then added to the bath after baseline measurements of osmotic water permeability (P(f)) and the change in P(f) was followed for one hour.	Water	79-84	arginine vasopressin	Homo sapiens	0-3
19791330-1	2005	A molecular dynamics simulation study is presented for the dynamics of the polarizability anisotropy of liquid water using the SPC/E model and a dipolar induction scheme that involves the intrinsic polarizability and first hyperpolarizability tensors obtained from ab initio quantum chemical calculations at the MP2/6-311++G(d,p) level.	Water	111-116	proline rich protein gene cluster	Homo sapiens	127-130
15752249-4	2005	Smad7 transgene expression within the kidney was tightly controlled by the addition of doxycycline in the daily drinking water.	Water	121-126	SMAD family member 7	Rattus norvegicus	0-5
15878016-2	2005	The water sample in the presence of the sediment was contaminated three times with Pb(II) in a laboratory experiment.	Water	4-9	submaxillary gland androgen regulated protein 3B	Homo sapiens	83-89
15878016-14	2005	In a short period of time the sediment responds as a self-cleaning system for Pb(II) contamination in the estuarine water, which may have a very important influence in environmental pollution.	Water	116-121	submaxillary gland androgen regulated protein 3B	Homo sapiens	78-84
15733928-12	2005	In KAS I, the hydrogen bonding partners are two histidine NE2 atoms, instead of a water and a NE2 side-chain atom in thiolase.	Water	82-87	3-oxoacyl-ACP synthase, mitochondrial	Homo sapiens	3-8
15775979-5	2005	Here we show that loss of E-cadherin in the epidermis in vivo results in perinatal death of mice due to the inability to retain a functional epidermal water barrier.	Water	151-156	cadherin 1	Mus musculus	26-36
15708367-9	2005	ICL and its product appear to be sensitive to oxidative damage; thus, association of CAT with ICL would afford protection from H(2)O(2).	Water	127-132	catalase isozyme 1-like	Ricinus communis	85-88
16851554-0	2005	A coupled reference interaction site model/molecular dynamics study of the potential of mean force curve of the SN2 Cl- + CH3Cl reaction in water.	Water	140-145	solute carrier family 38 member 5	Homo sapiens	112-115
16851472-1	2005	Molecular dynamics simulations of hydroxyl radical in water are carried out by use of a classical simple point charge extended (SPC/E) water model and a similar point charge model for hydroxyl radical.	Water	54-59	proline rich protein gene cluster	Homo sapiens	128-131
15819251-1	2005	Oxidation of arsenite, As(III), to arsenate, As(V), is required for the efficient removal of arsenic by many water treatment technologies.	Water	109-114	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	45-50
15740899-3	2005	cIEF-MS employing 1% Pharmalyte 3-10 and a sheath liquid containing water/methanol/acetic acid (50/49/1) resolved angiotensin I and II (5 microM each, DeltapI=0.2) at an Rs value of 2.29.	Water	68-73	angiotensinogen	Homo sapiens	114-134
16851472-2	2005	Structural and dynamical properties are studied along the coexistence curve of SPC/E water at 298, 373, 473, 573, and 633 K and above its critical point at 683, 733, 783, and 833 K with density fixed at 0.3 g/cm3.	Water	85-90	proline rich protein gene cluster	Homo sapiens	79-82
15732937-0	2005	Method for trace level analysis of C8, C9, C10, C11, and C13 perfluorocarbon carboxylic acids in water.	Water	97-102	homeobox C10	Homo sapiens	43-46
15528393-3	2005	Injection of ANG II into the lateral cerebral ventricle produced a robust water intake in mice and induced Fos-ir in SFO, as well as in median preoptic (MnPO) and paraventricular (PVN) nuclei.	Water	74-79	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	13-19
15743788-4	2005	Smad7 transgene expression within the kidney was tightly controlled by the addition of doxycycline in the daily drinking water.	Water	121-126	SMAD family member 7	Rattus norvegicus	0-5
15790116-5	2005	This electrode was successfully applied as an indicator electrode in the potentiometric titration of ascorbic acid and hydroquinone from pharmaceutical preparations as well as ascorbic acid in orange juice and dissolved O2 in tap water.	Water	230-235	SEC14 like lipid binding 2	Homo sapiens	226-229
15732937-4	2005	The lower limit of quantitation (LLOQ) for C8, C9, C10, C11, and C13 was determined to be 25 ng/L in water.	Water	101-106	homeobox C10	Homo sapiens	51-54
15756018-8	2005	Treatment of EGCG-rich GTP in drinking water to 4T1 cells bearing BALB/c mice resulted in reduction of tumor growth accompanied with increase in Bax/Bcl-2 ratio, reduction in proliferating cell nuclear antigen and activation of caspase 3 in tumors.	Water	39-44	B cell leukemia/lymphoma 2	Mus musculus	149-154
15976682-4	2005	Most, if not all, of the peripheral and central actions of angiotensin II, including vasoconstriction, renal salt and water retention, facilitation of sympathetic transmission, modification of vascular and cardiac structure, oxydative stress stimulation and proinflammatory action were all thought to be mediated by the angiotensin type 1 receptor, AT1.	Water	118-123	angiotensinogen	Homo sapiens	59-73
15683794-2	2005	The water monomers weakly hydrogen bonded with NO3- ions showed a positive peak near at 3565 cm(-1) for both Mg(NO3)2 and NH4NO3 solutions.	Water	4-9	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
15608130-3	2005	The assay is based on the release of tritium as tritiated water that occurs upon CYP3A4/5-mediated 6beta-hydroxylation of testosterone labeled with tritium in the 6beta position.	Water	58-63	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
15619089-0	2005	Water-soluble titanocene complexes with sulfur-containing amino acids: synthesis, spectroscopic, electrochemical and Ti(IV)-transferrin interaction studies.	Water	0-5	transferrin	Homo sapiens	124-135
15734284-6	2005	The results suggested that generation of H(2)O(2) and expression of CAT were coordinated and were indicative of epidermal differentiation as well as of the role of CAT in repairing redox damage by discomposing H(2)O(2).	Water	210-215	catalase	Rattus norvegicus	68-71
15734284-6	2005	The results suggested that generation of H(2)O(2) and expression of CAT were coordinated and were indicative of epidermal differentiation as well as of the role of CAT in repairing redox damage by discomposing H(2)O(2).	Water	210-215	catalase	Rattus norvegicus	164-167
15695526-3	2005	Recently, a number of agents have been developed to antagonize the effects of vasopressin by targeting its V1a and V2 receptors, which are involved in vascular tone and free water regulation, respectively.	Water	174-179	arginine vasopressin	Homo sapiens	78-89
15748169-3	2005	Treatment with hydrogen peroxide (H(2)O(2)) as a generator of ROS inhibited CNTF-mediated Jak/STAT signaling in all cultured nerve cells tested, including chick ciliary ganglion neurons, chick neural retina, HMN-1 motor neuron hybrid cells, and SH-SY5Y and BE(2)-C human neuroblastoma cells.	Water	34-39	ciliary neurotrophic factor	Gallus gallus	76-80
15748169-3	2005	Treatment with hydrogen peroxide (H(2)O(2)) as a generator of ROS inhibited CNTF-mediated Jak/STAT signaling in all cultured nerve cells tested, including chick ciliary ganglion neurons, chick neural retina, HMN-1 motor neuron hybrid cells, and SH-SY5Y and BE(2)-C human neuroblastoma cells.	Water	34-39	Janus kinase 3	Gallus gallus	90-93
15782918-9	2005	The water released from the gels during cooking was higher for the ESD2 than the ES2 group, which was not different from the C2 group, suggesting that ES followed by slow chilling reduced water-holding capacity compared with the ES2 and C2 groups.	Water	4-9	ess-2 splicing factor homolog	Homo sapiens	81-84
15683794-2	2005	The water monomers weakly hydrogen bonded with NO3- ions showed a positive peak near at 3565 cm(-1) for both Mg(NO3)2 and NH4NO3 solutions.	Water	4-9	NBL1, DAN family BMP antagonist	Homo sapiens	112-115
15683794-4	2005	Compared with perchlorate solutions, the positive peak of nitrate solutions has a red shift of about 20 cm(-1) and the peak area is about half of that of perchlorate solutions with the same concentrations, indicating that the hydrogen bonding between NO3- and water monomers is relative stronger than that between ClO4- and water monomers, and NO3- has a strict requirement on the orientation of water molecules when hydrogen bonded with water monomers due to its planar structure.	Water	260-265	NBL1, DAN family BMP antagonist	Homo sapiens	344-347
15683794-4	2005	Compared with perchlorate solutions, the positive peak of nitrate solutions has a red shift of about 20 cm(-1) and the peak area is about half of that of perchlorate solutions with the same concentrations, indicating that the hydrogen bonding between NO3- and water monomers is relative stronger than that between ClO4- and water monomers, and NO3- has a strict requirement on the orientation of water molecules when hydrogen bonded with water monomers due to its planar structure.	Water	324-329	NBL1, DAN family BMP antagonist	Homo sapiens	251-254
15683794-4	2005	Compared with perchlorate solutions, the positive peak of nitrate solutions has a red shift of about 20 cm(-1) and the peak area is about half of that of perchlorate solutions with the same concentrations, indicating that the hydrogen bonding between NO3- and water monomers is relative stronger than that between ClO4- and water monomers, and NO3- has a strict requirement on the orientation of water molecules when hydrogen bonded with water monomers due to its planar structure.	Water	324-329	NBL1, DAN family BMP antagonist	Homo sapiens	251-254
15683794-4	2005	Compared with perchlorate solutions, the positive peak of nitrate solutions has a red shift of about 20 cm(-1) and the peak area is about half of that of perchlorate solutions with the same concentrations, indicating that the hydrogen bonding between NO3- and water monomers is relative stronger than that between ClO4- and water monomers, and NO3- has a strict requirement on the orientation of water molecules when hydrogen bonded with water monomers due to its planar structure.	Water	324-329	NBL1, DAN family BMP antagonist	Homo sapiens	251-254
18969902-6	2005	The validation of the method is performed by the analyses of certified reference materials and comparing the result of Co(II) determination in river water sample by the proposed method with those obtained by ET AAS.	Water	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
15743623-2	2005	The fog drip water ranged from -30 to +27 per thousand in deltaD and -6.2 to +1.9 per thousand in delta(18)O, conforms to the equation deltaD=7.64delta(18)O+14.32, and was thought to contain water that has been evaporated and recycled terrestrial meteoric water.	Water	13-18	zinc finger protein, FOG family member 1	Homo sapiens	4-7
15743623-2	2005	The fog drip water ranged from -30 to +27 per thousand in deltaD and -6.2 to +1.9 per thousand in delta(18)O, conforms to the equation deltaD=7.64delta(18)O+14.32, and was thought to contain water that has been evaporated and recycled terrestrial meteoric water.	Water	191-196	zinc finger protein, FOG family member 1	Homo sapiens	4-7
15743623-2	2005	The fog drip water ranged from -30 to +27 per thousand in deltaD and -6.2 to +1.9 per thousand in delta(18)O, conforms to the equation deltaD=7.64delta(18)O+14.32, and was thought to contain water that has been evaporated and recycled terrestrial meteoric water.	Water	191-196	zinc finger protein, FOG family member 1	Homo sapiens	4-7
15743623-4	2005	The shallow soil water had a composition usually between those of the rain and fog drip, and was assumed to be a mixture of the two waters.	Water	17-22	zinc finger protein, FOG family member 1	Homo sapiens	79-82
15743623-5	2005	However, the soil water collected in dry season appeared to contain more fog drip water than that collected in rainy season.	Water	18-23	zinc finger protein, FOG family member 1	Homo sapiens	73-76
15713463-9	2005	On the basis of the present crystal structure of the hCNP-CF/phosphate complex, the available structure of the CPDase/cyclic-nucleotide analogue complex, and the recent functional studies of rat CNP-CF, we propose a possible substrate-binding mode and catalytic mechanism of CNP, which employs the nucleophilic water molecule activated by His310.	Water	311-316	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	53-57
15642457-0	2005	The interaction between OPH and paraoxon at the air-water interface studied by AFM and epifluorescence microscopies.	Water	52-57	acylaminoacyl-peptide hydrolase	Homo sapiens	24-27
15670923-0	2005	Docking studies on PARP-1 inhibitors: insights into the role of a binding pocket water molecule.	Water	81-86	poly(ADP-ribose) polymerase 1	Homo sapiens	19-25
15670923-2	2005	A particular attention was given to the role played by a water molecule present in some but not all the so far available crystal structures of the catalytic domain of PARP-1.	Water	57-62	poly(ADP-ribose) polymerase 1	Homo sapiens	167-173
15773494-2	2005	Tap water and alkaline solutions were used for absorption, and the influence of gas flow rate, water flow rate, and length of the ASH unit were investigated.	Water	4-9	SEC14 like lipid binding 2	Homo sapiens	0-3
15794568-15	2005	The present study also obtained a bell-shaped relationship between log Kf and log Kow (octanol-water partition coefficient) for PCB congeners with the maximum log Kf corresponding to log Kow approximately 6.5.	Water	95-100	pyruvate carboxylase	Homo sapiens	128-131
15669071-3	2005	At 100 mM DHAP, compared with the reactions in the DMF/H2O (1:4) mixture, the use of emulsion systems led to two- to three-fold improvements in the conversions of the FucA-catalyzed reactions.	Water	55-58	alpha-L-fucosidase 1	Homo sapiens	167-171
15695525-0	2005	The interfacial properties of ApoA-I and an amphipathic alpha-helix consensus peptide of exchangeable apolipoproteins at the triolein/water interface.	Water	134-139	apolipoprotein A1	Homo sapiens	30-36
15695525-10	2005	However, above approximately 19 mN/m (PiOFF) the entire apoA-I molecule desorbed into the water.	Water	90-95	apolipoprotein A1	Homo sapiens	56-62
15642457-1	2005	The paraoxon hydrolysis reaction catalyzed by organophosphorus hydrolase (OPH) monolayer at the air-water interface was studied.	Water	100-105	acylaminoacyl-peptide hydrolase	Homo sapiens	74-77
15782958-2	2005	The extraction of the PME isoenzymes involved washing the fresh tomato flesh with water in order to remove sugars and than solubilizing the enzymes with a diluted HCl solution at pH 1.6.	Water	82-87	pectinesterase/pectinesterase inhibitor U1	Solanum lycopersicum	22-25
15671159-6	2005	Here we show that a single residue substitution (N60G in rat AQP6) totally eliminates the anion permeability of AQP6 when expressed in Xenopus oocytes, but the N60G oocytes exhibit significantly higher osmotic water permeability under basal conditions.	Water	210-215	aquaporin 6	Rattus norvegicus	61-65
15672193-6	2005	Charcoal-catalyzed equilibration of s-[Co(tren-engly)]Cl(2).2H(2)O dissolved in water produced the s- (s-6), p- (p-6) and t-[Co(tren-engly)]2+ (t-6) isomers in comparable amounts.	Water	80-85	S100 calcium binding protein A12	Homo sapiens	113-116
15740398-4	2005	In one, nucleation of thin film water formed from deposition of vapor on BaF(2)(111) faces was explored with the finding that supercooling to -30 degrees C was required before freezing occurred.	Water	32-37	BANF family member 2	Homo sapiens	73-78
15678187-3	2005	CD results showed that PrP[Ac-106-126-NH(2)] mainly adopts an alpha-helical conformation in TFE-water mixture and in SDS micelles, while a predominantly random structure is observed in aqueous solution.	Water	96-101	prion protein	Homo sapiens	23-26
15740398-5	2005	In the other series, nucleation of liquid water on submerged BaF(2) crystals was studied.	Water	42-47	BANF family member 2	Homo sapiens	61-66
15744837-2	2005	This method combines the advantages that the silver nanoparticles and bovine serum albumin (BSA) can be precipitated simultaneously from water-in-oil microemulsion by the easy control of CO2 pressure, which was revealed by our high-pressure UV-VIS spectra.	Water	137-142	albumin	Homo sapiens	77-90
15665974-4	2005	The species resulting from the interaction of quercetin with proteins, when concentrated at the H2O/CCl4 interface, generate enhanced BSL signals characterized at 376.0 nm which were found to be proportional to human serum albumin (HSA) and bovine serum albumin (BSA) in the range of 1-1250 ng mL(-1) and 2-1250 ng mL(-1), respectively.	Water	96-99	albumin	Homo sapiens	217-230
15665974-4	2005	The species resulting from the interaction of quercetin with proteins, when concentrated at the H2O/CCl4 interface, generate enhanced BSL signals characterized at 376.0 nm which were found to be proportional to human serum albumin (HSA) and bovine serum albumin (BSA) in the range of 1-1250 ng mL(-1) and 2-1250 ng mL(-1), respectively.	Water	96-99	albumin	Homo sapiens	248-261
16019886-8	2005	While the primary emulsion was stirred without quenching, lysozyme in the inner water phase continued diffusing across the ethyl acetate phase into the aqueous continuous phase.	Water	80-85	lysozyme	Homo sapiens	58-66
15629108-4	2005	It is shown that ferrous LPO heterolytically cleaves hydrogen peroxide forming water and oxyferryl LPO (compound II).	Water	79-84	lactoperoxidase	Homo sapiens	25-28
16027808-1	2005	Active anti-stroke fraction of Cerebral preparation (extract of water-soluble molecules from brain tissue of animals with hemorrhagic stroke) decreased caspase-3 expression and improved survival of experimental animals in the acute period after hemorrhagic stroke.	Water	64-69	caspase 3	Homo sapiens	152-161
15710373-5	2005	Water-permeability (microm/min/atm) at 25 degrees C was higher in GV oocytes (0.13+/-0.01) than MII oocytes (0.06+/-0.01).	Water	0-5	serine-protein kinase ATM	Oryzias latipes	31-34
15657297-1	2005	The cystic fibrosis transmembrane conductance regulator (CFTR) is a phosphorylation- and ATP-dependent chloride channel that modulates salt and water transport across lung and gut epithelia.	Water	144-149	CF transmembrane conductance regulator	Homo sapiens	4-55
15657297-1	2005	The cystic fibrosis transmembrane conductance regulator (CFTR) is a phosphorylation- and ATP-dependent chloride channel that modulates salt and water transport across lung and gut epithelia.	Water	144-149	CF transmembrane conductance regulator	Homo sapiens	57-61
15574706-7	2005	The model offers new insight into the water transport across the (alpha4)2(beta2)3 nAChR channel, and may lead to a better understanding of the structures, dynamics, and functions of this family of ion channels.	Water	38-43	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	83-88
15683432-9	2005	The gastric content of MPO, TNF-alpha and IL-1beta were all increased after water-immersion stress and reduced to near normal levels by ATL-146e.	Water	76-81	interleukin 1 beta	Rattus norvegicus	42-50
16019886-9	2005	Emulsion droplets were also broken into smaller ones with ongoing stirring; this event also contributed to lysozyme leaking out of the inner water phase.	Water	141-146	lysozyme	Homo sapiens	107-115
15539403-2	2005	In the present study, we proceeded to determine whether expression of the two angiotensin II (ANGII) receptor subtypes (AT(1) and AT(2)) change in relation to maternal water-electrolyte homeostasis and fetal growth.	Water	168-173	angiotensinogen	Rattus norvegicus	78-92
15539403-2	2005	In the present study, we proceeded to determine whether expression of the two angiotensin II (ANGII) receptor subtypes (AT(1) and AT(2)) change in relation to maternal water-electrolyte homeostasis and fetal growth.	Water	168-173	angiotensinogen	Rattus norvegicus	94-99
15667174-3	2005	Such samples could be cleaned almost completely from artificial particulate contaminations by a fog consisting of water droplets (diameter range, 8-20 microm).	Water	114-119	zinc finger protein, FOG family member 1	Homo sapiens	96-99
15776928-5	2005	In the on-line format, the addition of 2.5% of NH4Cl to the sewage water sample (pH = 2.5) was necessary to increase the breakthrough volumes of the analytes in the C18 precolumn.	Water	67-72	Bardet-Biedl syndrome 9	Homo sapiens	165-168
15667188-7	2005	PM-IRRAS technique provides a powerful means to study the hydrolysis process catalyzed by phospholipase A2 at the air/water interface.	Water	118-123	phospholipase A2 group IB	Homo sapiens	90-106
15596131-6	2005	Furthermore, LPS increased the osmotic water permeability of MLE-12 cells.	Water	39-44	toll-like receptor 4	Mus musculus	13-16
15705184-10	2005	CONCLUSION: Our results reveal that the water transport in urinary concentration involves the downregulation of AQP2 and AQP3 expression in STZ mice.	Water	40-45	aquaporin 3	Mus musculus	121-125
15804764-3	2005	METHODS: EAU was induced in B10.RIII mice by immunization with interphotoreceptor retinoid-binding protein (IRBP) using routine methods, but without treatment with pertussis toxin (PTX).	Water	9-12	granzyme C	Mus musculus	28-31
15649093-8	2005	Better accuracy of identifying carcinomas and fatty tissues is reported using CART analysis of different combinations of ratios calculated from the relative levels of water, choline, and saturated and unsaturated lipids.	Water	167-172	CART prepropeptide	Homo sapiens	78-82
15651885-10	2005	The noncovalent interaction between human serum albumin (HSA) and [Gd(TTDA-BA)(H(2)O)](-) and [Gd(TTDA-MOBA)(H(2)O)](-) complexes containing a hydrophobic substituent was investigated by measuring the water proton relaxation rate of the aqueous solutions.	Water	201-206	albumin	Homo sapiens	42-55
15620868-0	2005	Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique.	Water	66-71	insulin	Homo sapiens	37-44
15596131-7	2005	These findings demonstrate that LPS increases cell surface AQP5 expression by changing its subcellular distribution and increases membrane osmotic water permeability through activation of p38 MAP kinase.	Water	147-152	toll-like receptor 4	Mus musculus	32-35
15620868-1	2005	The study aimed to produce solid lipid insulin-loaded micro-particles by the solvent-in-water emulsion-diffusion technique, using isobutyric acid as solvent phase, glyceryl monostearate or cetyl palmitate as lipid, soya lecithin and taurodeoxycholate as emulsifiers.	Water	88-93	insulin	Homo sapiens	39-46
15353403-5	2005	Seven days of high salt (1% NaCl in drinking water) increased eNOS expression in THALs by 125 +/- 31%.	Water	45-50	nitric oxide synthase 3	Homo sapiens	62-66
15707054-4	2005	It is with this aim that we review here the benefit of using a coupled isotopic approach (delta15N and delta11B), in addition to conventional hydrogeological analyses, to trace the origin of NO3 in water.	Water	198-203	NBL1, DAN family BMP antagonist	Homo sapiens	191-194
15611372-9	2005	In addition, LPS-induced increase in lung water content and pulmonary myeloperoxidase activity was significantly reduced.	Water	42-47	toll-like receptor 4	Mus musculus	13-16
15641853-2	2005	Water is modeled using the extended simple point charge (SPC/E) model.	Water	0-5	proline rich protein gene cluster	Homo sapiens	57-60
15331385-5	2005	This report shows that guinea pigs express BHMT in the liver, kidney, and pancreas and that the steady-state levels of BHMT mRNA in kidney and liver decrease 68% and 93% in guinea pigs consuming tap water containing high levels of salt compared with animals provided untreated tap water.	Water	199-204	betaine--homocysteine S-methyltransferase 1	Cavia porcellus	43-47
15331385-5	2005	This report shows that guinea pigs express BHMT in the liver, kidney, and pancreas and that the steady-state levels of BHMT mRNA in kidney and liver decrease 68% and 93% in guinea pigs consuming tap water containing high levels of salt compared with animals provided untreated tap water.	Water	199-204	betaine--homocysteine S-methyltransferase 1	Cavia porcellus	119-123
15331385-5	2005	This report shows that guinea pigs express BHMT in the liver, kidney, and pancreas and that the steady-state levels of BHMT mRNA in kidney and liver decrease 68% and 93% in guinea pigs consuming tap water containing high levels of salt compared with animals provided untreated tap water.	Water	281-286	betaine--homocysteine S-methyltransferase 1	Cavia porcellus	119-123
16366286-0	2005	Measurement and modelling of water desorption isotherms for pasta at different temperatures.	Water	29-34	solute carrier family 45 member 1	Homo sapiens	60-65
15735363-5	2005	By using Laurdan, an increase was observed in generalized polarization (GP(340)) in both groups of rats (the one that drank tap water and the one that drank SMW) compared with the controls.	Water	128-133	nuclear RNA export factor 1	Rattus norvegicus	124-127
15667557-2	2005	METHODS: Double-distilled water and adjuvant were added to the naked pcDNA3.1/IFN-gamma, target vector ASOR-PLL and the ASOR-PLL-pcDNA3.1/IFN-gamma complex to create different conformations; molecules that were transfected into BEL7402 cells and the expression efficiency was determined by measuring the IFN-g concentration in the culture supernatant by ELISA.	Water	26-31	interferon gamma	Homo sapiens	78-87
15667557-2	2005	METHODS: Double-distilled water and adjuvant were added to the naked pcDNA3.1/IFN-gamma, target vector ASOR-PLL and the ASOR-PLL-pcDNA3.1/IFN-gamma complex to create different conformations; molecules that were transfected into BEL7402 cells and the expression efficiency was determined by measuring the IFN-g concentration in the culture supernatant by ELISA.	Water	26-31	interferon gamma	Homo sapiens	78-83
15458969-10	2005	Water deprivation significantly increased osmolality and hematocrit, as well as plasma protein and vasopressin concentrations.	Water	0-5	arginine vasopressin	Rattus norvegicus	99-110
15471976-3	2005	Aortas of Tg(p22smc) mice had increased p22(phox) and Nox1 protein levels and produced more superoxide and H(2)O(2).	Water	107-112	dynein cytoplasmic 1 heavy chain 1	Mus musculus	13-16
15813652-6	2005	The adverse reaction profile of the COX-2 inhibitors has confirmed the role of the COX-2 enzyme in renal function, salt and water homeostasis and the vascular endothelium.	Water	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
15644663-7	2005	High tidal volume ventilation increased In-transferrin plasma to lung flux in such a way that I(111)In-transferrin behaved like a marker of water.	Water	140-145	transferrin	Rattus norvegicus	103-114
15773285-2	2005	The insulin nanoparticles were prepared by a water-in-oil-in-water emulsification and evaporation method.	Water	45-50	insulin	Homo sapiens	4-11
15773285-2	2005	The insulin nanoparticles were prepared by a water-in-oil-in-water emulsification and evaporation method.	Water	61-66	insulin	Homo sapiens	4-11
15949534-3	2005	The necessarily high water permeability of the choroid plexus barrier is made possible by the abundant expression of a water channel, Aquaporin-1 (AQP1), on the apical side of the membrane from early stages of development through adulthood.	Water	21-26	aquaporin 1 (Colton blood group)	Homo sapiens	134-145
15949534-3	2005	The necessarily high water permeability of the choroid plexus barrier is made possible by the abundant expression of a water channel, Aquaporin-1 (AQP1), on the apical side of the membrane from early stages of development through adulthood.	Water	21-26	aquaporin 1 (Colton blood group)	Homo sapiens	147-151
15949534-3	2005	The necessarily high water permeability of the choroid plexus barrier is made possible by the abundant expression of a water channel, Aquaporin-1 (AQP1), on the apical side of the membrane from early stages of development through adulthood.	Water	119-124	aquaporin 1 (Colton blood group)	Homo sapiens	134-145
15949534-3	2005	The necessarily high water permeability of the choroid plexus barrier is made possible by the abundant expression of a water channel, Aquaporin-1 (AQP1), on the apical side of the membrane from early stages of development through adulthood.	Water	119-124	aquaporin 1 (Colton blood group)	Homo sapiens	147-151
15949534-12	2005	An appreciation of AQP1 as an ion channel in addition to its role as a water channel should offer new targets for therapeutic strategies in diseases involving water imbalance in the brain.	Water	159-164	aquaporin 1 (Colton blood group)	Homo sapiens	19-23
15813652-6	2005	The adverse reaction profile of the COX-2 inhibitors has confirmed the role of the COX-2 enzyme in renal function, salt and water homeostasis and the vascular endothelium.	Water	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
15991886-1	2005	Lubiprostone [RU 0211, SPI 0211] is a bicyclic fatty acid that acts as a chloride channel opener, increasing intestinal water secretion.	Water	120-125	chromogranin A	Homo sapiens	23-26
15859419-4	2005	The water flux of the membrane prepared from the PSf/A/PEG-4000/DMAc casting solution was 115.2mL x (cm2 x h)-1, six time as much as membrane without PEG-0.	Water	4-9	insulin like growth factor binding protein 7	Homo sapiens	49-52
16108230-1	2005	Drinking of original mineral water "Naftussya" from Truskavets spa by the healthy adult rats during 3 weeks led to increase the urinary, biliary, cholates and cholesterol extraction by 54%, 72%, 69% and 83%, respectively with no influence on the enteric water absorption.	Water	29-34	surfactant protein A1	Rattus norvegicus	63-66
16596811-4	2005	For instance, the ABCG5/ABCG8 couple is crucial for hepatobiliary and intestinal cholesterol excretion, while ABCA1 is essential for high-density lipoprotein formation and, hence, for inter-organ trafficking of the highly water-insoluble cholesterol molecules.	Water	222-227	ATP binding cassette subfamily G member 5	Homo sapiens	18-23
15748828-10	2005	Aromatase activity was evaluated in ovarian epithelial cancer (OEC) cell lines by the tritiated water assay and the effects of third-generation aromatase inhibitors (AIs) on aromatase activity and growth were studied.	Water	96-101	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
26641127-1	2005	A methodology for large scale molecular dynamics simulation of a solvated polarizable protein, using a combination of permanent and inducible point dipoles with fluctuating and fixed charges, is discussed and applied to the simulation of water solvated bovine pancreatic trypsin inhibitor (BPTI).	Water	238-243	trophoblast Kunitz domain protein 1	Bos taurus	271-288
15533880-6	2005	Semi-quantitative RT-PCR demonstrated that transitory water deficit during meiosis selectively down-regulated the transcription of two of the three genes, one encoding the vacuolar (Ivr5) and the other a cell-wall (Ivr1) isoform, without affecting the Ivr3 message.	Water	54-59	ATP synthase subunit alpha, chloroplastic	Triticum aestivum	215-219
15328380-5	2005	Potent activation of ERK and moderate activation of stress-activated protein kinase/c-Jun NH(2)-terminal kinase occurred within 30 min of 1 mM H(2)O(2) treatment.	Water	143-148	mitogen-activated protein kinase 1	Homo sapiens	21-24
15629660-2	2005	Complete conical series were collected from replicas of the water channel aquaporin-0 (AQP0), a 6.6 nm side tetramer with a molecular weight of approximately 120 kDa that was purified and reconstituted in liposomes.	Water	60-65	major intrinsic protein of lens fiber	Homo sapiens	74-85
15629660-2	2005	Complete conical series were collected from replicas of the water channel aquaporin-0 (AQP0), a 6.6 nm side tetramer with a molecular weight of approximately 120 kDa that was purified and reconstituted in liposomes.	Water	60-65	major intrinsic protein of lens fiber	Homo sapiens	87-91
15912266-5	2005	Cells in different cell cycle phases after release were treated with the water-soluble photosensitizer, ATX-S10(Na).	Water	73-78	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	104-107
15610244-16	2005	It is concluded that the increase in water reabsorption in the CD is an adaptive response of the kidney to a long period of food deprivation and is mediated via a vasopressin-independent mechanism.	Water	37-42	arginine vasopressin	Rattus norvegicus	163-174
16738530-3	2005	The V2 vasopressin receptor is coupled to Gs protein and adenylyl cyclase and is responsible for water reabsorption in the renal collecting duct.	Water	97-102	arginine vasopressin	Homo sapiens	7-18
15715267-12	2005	The heating of As(V) in the presence of gluconate, glucose, ascorbic acid, methionine, isoleucine, sodium chloride, and pure water, in autoclave for 15 minutes, showed that, whereas no As(III) was found in pure water and sodium chloride solution, approximately 50% of As(V) was converted into As(III) in the remainder of the solutions.	Water	125-130	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	15-20
15715267-12	2005	The heating of As(V) in the presence of gluconate, glucose, ascorbic acid, methionine, isoleucine, sodium chloride, and pure water, in autoclave for 15 minutes, showed that, whereas no As(III) was found in pure water and sodium chloride solution, approximately 50% of As(V) was converted into As(III) in the remainder of the solutions.	Water	211-216	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	15-20
15675318-1	2005	Clinical and laboratory experiments have demonstrated that arginine vasopressin (AVP), renin-aldosterone system and catecholamines play a crucial role in water and sodium retention in edematous diseases, including congestive heart failure, nephrotic syndrome and liver cirrhosis.	Water	154-159	arginine vasopressin	Homo sapiens	68-79
16399355-4	2005	Hydroxylation of the formylglycine residue by a water molecule forming the activated hydroxylformylglycine (a formylglycine hydrate or a gem-diol) is a necessary step for sulfatase activity of the enzyme.	Water	48-53	arylsulfatase family member H	Homo sapiens	171-180
15692221-1	2005	BACKGROUND/AIMS: Water diuresis usually increases medullary oxygenation as a result of increased medullary synthesis of prostaglandins, but it is not clear whether this involves activation of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2).	Water	17-22	prostaglandin-endoperoxide synthase 1	Homo sapiens	192-208
15692221-1	2005	BACKGROUND/AIMS: Water diuresis usually increases medullary oxygenation as a result of increased medullary synthesis of prostaglandins, but it is not clear whether this involves activation of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2).	Water	17-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	220-236
15692221-1	2005	BACKGROUND/AIMS: Water diuresis usually increases medullary oxygenation as a result of increased medullary synthesis of prostaglandins, but it is not clear whether this involves activation of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2).	Water	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
15692221-8	2005	CONCLUSION: Renal medullary oxygenation is improved by water diuresis in normal young women in a way that is blocked by a selective inhibitor of COX-2 as well as non-selective cyclooxygenase inhibitors.	Water	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
15719846-4	2005	Vasopressin stimulates the V2 receptors in the kidney leading to reabsorption of water through aquaporin 2.	Water	81-86	arginine vasopressin	Homo sapiens	0-11
15719846-5	2005	However, in vasodilatory shock the antidiuretic effects are overcome by the effect vasopressin has on the kidneys: improvement of renal blood flow leading to water excretion.	Water	158-163	arginine vasopressin	Homo sapiens	83-94
15675318-1	2005	Clinical and laboratory experiments have demonstrated that arginine vasopressin (AVP), renin-aldosterone system and catecholamines play a crucial role in water and sodium retention in edematous diseases, including congestive heart failure, nephrotic syndrome and liver cirrhosis.	Water	154-159	arginine vasopressin	Homo sapiens	81-84
15675318-1	2005	Clinical and laboratory experiments have demonstrated that arginine vasopressin (AVP), renin-aldosterone system and catecholamines play a crucial role in water and sodium retention in edematous diseases, including congestive heart failure, nephrotic syndrome and liver cirrhosis.	Water	154-159	renin	Homo sapiens	87-92
15675318-4	2005	AVP increases abundance of aquaporin-2 protein in renal collecting duct cells, and enhances renal water reabsorption.	Water	98-103	arginine vasopressin	Homo sapiens	0-3
15667881-1	2005	OBJECTIVES: To investigate the immunoexpression of aquaporin-1 (AQP-1), a major transmembrane water channel, in high-grade varicocele testes, which are known to imply an unbalanced transmembrane water flow, in both tubular and extratubular compartments.	Water	195-200	aquaporin 1 (Colton blood group)	Homo sapiens	51-62
15770929-1	2005	BACKGROUND: In peritoneal dialysis, approximately 40% of the total osmotic ultrafiltration (UF) induced by glucose can be predicted to be due to "free" water transport across aquaporin-1 (APQ-1).	Water	152-157	aquaporin 1 (Colton blood group)	Homo sapiens	175-186
20021092-3	2005	A significant diminution was noted in the activities of catalase and peroxidase, important antioxidant enzymes in testicular tissue, sperm pellet, prostate, and epididymis in sodium fluoride-treated rats at the dose of 20 mg/kg body weight/day (the level noted in drinking water in fluoride intoxicated areas) for 30 days by oral gavage.	Water	273-278	catalase	Rattus norvegicus	56-64
15667881-1	2005	OBJECTIVES: To investigate the immunoexpression of aquaporin-1 (AQP-1), a major transmembrane water channel, in high-grade varicocele testes, which are known to imply an unbalanced transmembrane water flow, in both tubular and extratubular compartments.	Water	94-99	aquaporin 1 (Colton blood group)	Homo sapiens	51-62
15667881-1	2005	OBJECTIVES: To investigate the immunoexpression of aquaporin-1 (AQP-1), a major transmembrane water channel, in high-grade varicocele testes, which are known to imply an unbalanced transmembrane water flow, in both tubular and extratubular compartments.	Water	94-99	aquaporin 1 (Colton blood group)	Homo sapiens	64-69
15576568-1	2005	Extended proteins such as calmodulin and troponin C have two globular terminal domains linked by a central region that is exposed to water and often acts as a function-regulating element.	Water	133-138	calmodulin 1	Homo sapiens	26-36
16285018-3	2005	These adducts are reactive towards nucleophiles and react with deoxyguanosine (dGMP) to form the ternary trans-[Pt(dGMP)(S-Met1-Ub) (Am)(pip-pip)] complex which is stable in water and even in the presence of excess glutathione (GSH).	Water	174-179	prolactin induced protein	Homo sapiens	137-140
16285018-3	2005	These adducts are reactive towards nucleophiles and react with deoxyguanosine (dGMP) to form the ternary trans-[Pt(dGMP)(S-Met1-Ub) (Am)(pip-pip)] complex which is stable in water and even in the presence of excess glutathione (GSH).	Water	174-179	prolactin induced protein	Homo sapiens	141-144
15667881-1	2005	OBJECTIVES: To investigate the immunoexpression of aquaporin-1 (AQP-1), a major transmembrane water channel, in high-grade varicocele testes, which are known to imply an unbalanced transmembrane water flow, in both tubular and extratubular compartments.	Water	195-200	aquaporin 1 (Colton blood group)	Homo sapiens	64-69
15650969-2	2005	Orally applicable vasopressin-V2-receptor antagonists are an interesting novel therapeutic approach for the elimination of free water.	Water	128-133	arginine vasopressin receptor 2	Homo sapiens	18-41
15509592-1	2004	Vasopressin regulates water homeostasis through insertion of homotetrameric aquaporin-2 (AQP2) water channels in the apical plasma membrane of renal cells.	Water	22-27	arginine vasopressin	Homo sapiens	0-11
16180444-7	2005	Final water turbidity was &lt; 1.0 NTU, COD &lt; 20 mg L(-1) O2 and 71 mNm(-1), the liquid/air interfacial tension.	Water	6-11	L1 cell adhesion molecule	Homo sapiens	55-70
15641356-0	2004	Human insulin and desamido human insulin isotherms in ethanol-water reversed phase systems.	Water	62-67	insulin	Homo sapiens	6-13
15641356-0	2004	Human insulin and desamido human insulin isotherms in ethanol-water reversed phase systems.	Water	62-67	insulin	Homo sapiens	33-40
15592307-10	2004	The AQP9 expression in fetal membranes suggests that AQP9 may be an important water channel in intramembranous amniotic fluid water regulation.	Water	78-83	aquaporin 9	Homo sapiens	4-8
15492926-7	2004	The CYP3A5*1/*3 polymorphism, which is likely to influence salt and water retention and risk for salt-sensitive hypertension, was genotyped in &gt;1,000 individuals from 52 worldwide population samples.	Water	68-73	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	4-10
15592307-10	2004	The AQP9 expression in fetal membranes suggests that AQP9 may be an important water channel in intramembranous amniotic fluid water regulation.	Water	78-83	aquaporin 9	Homo sapiens	53-57
15592307-10	2004	The AQP9 expression in fetal membranes suggests that AQP9 may be an important water channel in intramembranous amniotic fluid water regulation.	Water	126-131	aquaporin 9	Homo sapiens	4-8
15592307-10	2004	The AQP9 expression in fetal membranes suggests that AQP9 may be an important water channel in intramembranous amniotic fluid water regulation.	Water	126-131	aquaporin 9	Homo sapiens	53-57
15607625-1	2004	Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension.	Water	135-140	arginine vasopressin	Rattus norvegicus	0-11
15607625-1	2004	Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension.	Water	135-140	arginine vasopressin	Rattus norvegicus	13-16
15588700-8	2004	The formal redox potential of the His/H(2)O complex of cytochrome c in 9 M urea at pH 3 was estimated to be -0.13 V, ca.	Water	38-43	cytochrome c, somatic	Homo sapiens	55-67
15689027-0	2004	Identification of levoglucosan and related steroisomers in fog water as a biomass combustion tracer by ESI-MS/MS.	Water	63-68	zinc finger protein, FOG family member 1	Homo sapiens	59-62
15689027-1	2004	A conspicuous fraction of the water soluble organic compounds (WSOC) in fog and fine aerosol samples is composed by monosaccharide anhydrides, such as levoglucosan and its stereoisomers, galactosan and mannosan.	Water	30-35	zinc finger protein, FOG family member 1	Homo sapiens	72-75
15577213-6	2004	Increases in indices of renal function, plasma urea nitrogen, were significantly inhibited in rats treated with the Eriobotrya japonica extract compared to rats treated with tap water.	Water	178-183	nuclear RNA export factor 1	Rattus norvegicus	174-177
15679109-4	2004	Truncation by 125 amino acid residues of the Cx43 C-terminal region led to an altered epidermal expression pattern of Cx43 and defective development of the epidermal water barrier in transgenic mice, although the truncated Cx43 protein could still form open gap junctional channels in transfected HeLa cells.	Water	166-171	gap junction protein, alpha 1	Mus musculus	45-49
15653433-1	2004	Degradation of membrane-bound sphingomyelin to phosphorylcholine and ceramide is catalyzed by the water-soluble lysosomal acid sphingomyelinase (A-SMase).	Water	98-103	sphingomyelin phosphodiesterase 1	Homo sapiens	122-143
15653433-1	2004	Degradation of membrane-bound sphingomyelin to phosphorylcholine and ceramide is catalyzed by the water-soluble lysosomal acid sphingomyelinase (A-SMase).	Water	98-103	sphingomyelin phosphodiesterase 1	Homo sapiens	145-152
15526264-8	2004	Target chemical analyses showed that the water, sediment, and serum samples tested positive for p-nonylphenol (p-NP).	Water	41-46	purine nucleoside phosphorylase	Homo sapiens	111-115
15526264-9	2004	The p-NP level in water and sediment at MD was 6360 and 4.0 microg/kg, respectively, whereas in sediment at RVD it was 113 microg/kg.	Water	18-23	purine nucleoside phosphorylase	Homo sapiens	4-8
15526270-9	2004	In contrast, all river-water samples triggered secretion of proinflammatory cytokines, as shown for TNF-alpha, IL-1beta, and IL-6.	Water	23-28	tumor necrosis factor	Homo sapiens	100-109
15526270-9	2004	In contrast, all river-water samples triggered secretion of proinflammatory cytokines, as shown for TNF-alpha, IL-1beta, and IL-6.	Water	23-28	interleukin 1 beta	Homo sapiens	111-119
15526270-9	2004	In contrast, all river-water samples triggered secretion of proinflammatory cytokines, as shown for TNF-alpha, IL-1beta, and IL-6.	Water	23-28	interleukin 6	Homo sapiens	125-129
15564445-0	2004	Prevention of spontaneous and experimentally induced diabetes in mice with zinc sulfate-enriched drinking water is associated with activation and reduction of NF-kappa B and AP-1 in islets, respectively.	Water	106-111	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	159-169
15310557-4	2004	The inhibitory effects of CRP were reversed by phosphorylcholine, a water-soluble CRP ligand.	Water	68-73	C-reactive protein	Bos taurus	26-29
15310557-4	2004	The inhibitory effects of CRP were reversed by phosphorylcholine, a water-soluble CRP ligand.	Water	68-73	C-reactive protein	Bos taurus	82-85
15648393-1	2004	Uptake of aromatic hydrocarbon vapors (benzene and phenanthrene) by typical micrometer-sized fog-water droplets was studied using a falling droplet reactor at temperatures between 296 and 316 K. Uptake of phenanthrene vapor greater than that predicted by bulk (air-water)-phase equilibrium was observed for diameters less than 200 microm, and this was attributed to surface adsorption.	Water	97-102	zinc finger protein, FOG family member 1	Homo sapiens	93-96
15828342-7	2004	Microenvironment of trp residue in PPO is more hydrophobic than that of free trp in water.	Water	84-89	protoporphyrinogen oxidase	Homo sapiens	35-38
16019305-9	2004	Studies on the blood enzyme levels of rats showed that while alanine aminotransferase was not affected, aspartate aminotransferase was significantly affected by oral administration of organic solvent-free water and methanol:water (1:1) extractives (P = 0.023 and P = 0.0044), respectively.	Water	205-210	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	104-130
16019305-9	2004	Studies on the blood enzyme levels of rats showed that while alanine aminotransferase was not affected, aspartate aminotransferase was significantly affected by oral administration of organic solvent-free water and methanol:water (1:1) extractives (P = 0.023 and P = 0.0044), respectively.	Water	224-229	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	104-130
15614025-1	2004	OBJECTIVE: Angiotensin II and aldosterone, generated by the angiotensin-converting enzyme (ACE) and aldosterone synthase (CYP11B2), respectively, not only regulate sodium and water homeostasis, but also influence vascular remodeling in response to high blood pressure.	Water	175-180	angiotensinogen	Homo sapiens	11-25
15579798-4	2004	Only the higher GHRH dose also increased total body water (tritium space; P = 0.024) and fat-free mass (dual-energy x-ray absorptiometry; P = 0.021), and reduced total abdominal adiposity (computed axial tomography scan; P = 0.042).	Water	52-57	growth hormone releasing hormone	Homo sapiens	16-20
15579798-8	2004	We conclude that sc administration of a large dose of GHRH (4 mg) twice daily for 3 months elevates GH and IGF-I concentrations, increases total body water and fat-free mass, reduces total abdominal adiposity, and enhances certain performance measures in healthy aging men but causes local skin reactions.	Water	150-155	growth hormone releasing hormone	Homo sapiens	54-58
15541505-5	2004	The crystal of [CdCl2(DL-Hpipe-2)(H2O)] is orthorhombic with the space group Pca2(1).	Water	34-37	prostate cancer associated transcript 2	Homo sapiens	77-81
15614025-1	2004	OBJECTIVE: Angiotensin II and aldosterone, generated by the angiotensin-converting enzyme (ACE) and aldosterone synthase (CYP11B2), respectively, not only regulate sodium and water homeostasis, but also influence vascular remodeling in response to high blood pressure.	Water	175-180	angiotensin I converting enzyme	Homo sapiens	60-89
15614025-1	2004	OBJECTIVE: Angiotensin II and aldosterone, generated by the angiotensin-converting enzyme (ACE) and aldosterone synthase (CYP11B2), respectively, not only regulate sodium and water homeostasis, but also influence vascular remodeling in response to high blood pressure.	Water	175-180	angiotensin I converting enzyme	Homo sapiens	91-94
15504347-1	2004	Arginine vasopressin (AVP) plays a major role in the modulation of water reabsorption in mammalian kidney.	Water	67-72	arginine vasopressin	Homo sapiens	9-20
15469988-1	2004	Binding of arginine-vasopressin (AVP) to its V2 receptor (V2R) in the basolateral membrane of principal cells induces Aquaporin-2-mediated water reabsorption in the kidney.	Water	139-144	arginine vasopressin	Homo sapiens	20-31
15469988-1	2004	Binding of arginine-vasopressin (AVP) to its V2 receptor (V2R) in the basolateral membrane of principal cells induces Aquaporin-2-mediated water reabsorption in the kidney.	Water	139-144	arginine vasopressin receptor 2	Homo sapiens	58-61
15636291-10	2004	A single PFGE clone was predominant among water isolates (9 of 10) and available patient isolates (14 of 19).	Water	42-47	sulfatase modifying factor 2	Homo sapiens	9-13
15638162-5	2004	Water samples need a pH adjustment to values lower than 3 units and must be percolated through the cartridges with flow rates over 5 mL min(-1).	Water	0-5	CD59 molecule (CD59 blood group)	Homo sapiens	136-142
15501701-1	2004	The motor response to vasopressin, a neuropeptide promoting the reabsorption of water, was isometrically investigated in vitro in human renal calyces and pelvis in relation to possible modulation of urinary flow by these tubular structures.	Water	80-85	arginine vasopressin	Homo sapiens	22-33
15501701-10	2004	Our results can be interpreted to imply that the tonic contractions induced by vasopressin facilitate the reabsorption of water by increasing the hydraulic resistance of the tubular structures below collecting ducts.	Water	122-127	arginine vasopressin	Homo sapiens	79-90
15518636-6	2004	Pretreatment with the AT(1) receptor antagonist eliminated Ang II-induced increases in blood pressure, water intake, and sympathoadrenal catecholamine release; inhibited peripheral and brain AT(1) receptors; increased AT(2) receptor binding in the locus coeruleus, inferior olive, and adrenal cortex; and decreased AT(2) receptor binding in the adrenal medulla.	Water	103-108	angiotensinogen	Rattus norvegicus	59-65
15504347-1	2004	Arginine vasopressin (AVP) plays a major role in the modulation of water reabsorption in mammalian kidney.	Water	67-72	arginine vasopressin	Homo sapiens	22-25
15531785-3	2004	Enzyme production was very high (7832 U/g of dry moldy bran) when wheat bran was moistened with tap water at a substrate--to--moistening agent ratio of 1:2.5 (w/v) and an inoculum level of 3 x 106 spores/10 g of wheat bran at a water activity (aw) of 0.95.	Water	100-105	common wheat expressed sequence tag	Triticum aestivum	96-99
15347643-1	2004	We have previously demonstrated that vasopressin increases the water permeability of the inner medullary collecting duct (IMCD) by inducing trafficking of aquaporin-2 to the apical plasma membrane and that this response is dependent on intracellular calcium mobilization and calmodulin activation.	Water	63-68	arginine vasopressin	Rattus norvegicus	37-48
15347643-2	2004	Here, we address the hypothesis that this water permeability response is mediated in part through activation of the calcium/calmodulin-dependent myosin light chain kinase (MLCK) and regulation of non-muscle myosin II.	Water	42-47	myosin light chain kinase	Rattus norvegicus	145-170
15347643-2	2004	Here, we address the hypothesis that this water permeability response is mediated in part through activation of the calcium/calmodulin-dependent myosin light chain kinase (MLCK) and regulation of non-muscle myosin II.	Water	42-47	myosin light chain kinase	Rattus norvegicus	172-176
15347643-7	2004	The MLCK inhibitor ML-7 blocked the DDAVP-induced MLC phosphorylation and substantially reduced [Arg8]vasopressin (AVP)-stimulated water permeability.	Water	131-136	myosin light chain kinase	Rattus norvegicus	4-8
15347643-7	2004	The MLCK inhibitor ML-7 blocked the DDAVP-induced MLC phosphorylation and substantially reduced [Arg8]vasopressin (AVP)-stimulated water permeability.	Water	131-136	arginine vasopressin	Rattus norvegicus	102-113
15347643-9	2004	These results demonstrate that MLC phosphorylation by MLCK represents a downstream effect of AVP-activated calcium/calmodulin signaling in IMCD cells and point to a role for non-muscle myosin II in regulation of water permeability by vasopressin.	Water	212-217	myosin light chain kinase	Rattus norvegicus	54-58
15464797-0	2004	Adsorption equilibrium modeling and solution chemistry dependence of fluoride removal from water by trivalent-cation-exchanged zeolite F-9.	Water	91-96	coagulation factor IX	Homo sapiens	135-138
15231495-3	2004	Relative to control, ET-1 produced extensive mast cell degranulation as well as a significant increase in myocardial water content (78.8 +/- 1.5% vs. 74.2 +/- 2.2%, P &lt;0.01), a marked 107% increase in MMP-2 activity (P &lt;0.05), and a substantial decrease in collagen volume fraction (0.69 +/- 0.09% vs. 0.99 +/- 0.04%, P &lt;0.001).	Water	117-122	endothelin 1	Rattus norvegicus	21-25
15542322-2	2004	From circular dichroic (CD) measurement, CD spectra of cytochrome c, which is solubilized at the interface of reverse micelles, markedly changed on going from buffer solution to the reverse micellar solution, and the ellipticity values in the far- and near-UV regions decreased with decreasing the water content (W0: molar ratio of water to AOT), indicating that the secondary and tertiary structures of cytochrome c changed with the water content.	Water	298-303	cytochrome c, somatic	Homo sapiens	55-67
15542322-2	2004	From circular dichroic (CD) measurement, CD spectra of cytochrome c, which is solubilized at the interface of reverse micelles, markedly changed on going from buffer solution to the reverse micellar solution, and the ellipticity values in the far- and near-UV regions decreased with decreasing the water content (W0: molar ratio of water to AOT), indicating that the secondary and tertiary structures of cytochrome c changed with the water content.	Water	332-337	cytochrome c, somatic	Homo sapiens	55-67
15542322-2	2004	From circular dichroic (CD) measurement, CD spectra of cytochrome c, which is solubilized at the interface of reverse micelles, markedly changed on going from buffer solution to the reverse micellar solution, and the ellipticity values in the far- and near-UV regions decreased with decreasing the water content (W0: molar ratio of water to AOT), indicating that the secondary and tertiary structures of cytochrome c changed with the water content.	Water	332-337	cytochrome c, somatic	Homo sapiens	55-67
15527354-3	2004	120, 8107 (2004)] to the fluctuating charge (SPC-FQ) model of liquid water developed by Rick, Stuart, and Berne [J. Chem.	Water	69-74	proline rich protein gene cluster	Homo sapiens	45-48
15527354-7	2004	This result is significantly longer than the 0.9 ps decay previously calculated for the nonpolarizable SPC/E water model.	Water	109-114	proline rich protein gene cluster	Homo sapiens	103-106
15253895-1	2004	Aquaporin-2 (AQP2) is the vasopressin-sensitive water channel that regulates water reabsorption in the distal nephron collecting duct.	Water	48-53	aquaporin 2 S homeolog	Xenopus laevis	0-11
15253895-1	2004	Aquaporin-2 (AQP2) is the vasopressin-sensitive water channel that regulates water reabsorption in the distal nephron collecting duct.	Water	48-53	aquaporin 2 S homeolog	Xenopus laevis	13-17
15253895-1	2004	Aquaporin-2 (AQP2) is the vasopressin-sensitive water channel that regulates water reabsorption in the distal nephron collecting duct.	Water	77-82	aquaporin 2 S homeolog	Xenopus laevis	0-11
15253895-1	2004	Aquaporin-2 (AQP2) is the vasopressin-sensitive water channel that regulates water reabsorption in the distal nephron collecting duct.	Water	77-82	aquaporin 2 S homeolog	Xenopus laevis	13-17
15476806-0	2004	Thermodynamic signature of GCN4-bZIP binding to DNA indicates the role of water in discriminating between the AP-1 and ATF/CREB sites.	Water	74-79	glial cell derived neurotrophic factor	Homo sapiens	119-122
15549173-4	2004	We review here the biological actions of Ang-(1-7) and discuss how this discovery may change altogether the perception of how the renin angiotensin system functions in the regulation of tissue perfusion pressure and the regulation of salt and water metabolism.	Water	243-248	renin	Homo sapiens	130-135
15504987-6	2004	In contrast, the insulin-treated women did not lose body fat and gained 1.04 kg body wt due to a rise in extracellular water.	Water	119-124	insulin	Homo sapiens	17-24
15496149-2	2004	In the adult kidney, somatostatin alters renal blood flow, ion transport, and water permeability.	Water	78-83	somatostatin	Mus musculus	21-33
15454227-1	2004	The tetrahydrochloride salt of astaxanthin di-L-lysinate (lys(2)AST) is a highly water-dispersible astaxanthin-amino acid conjugate, with an aqueous dispersibility of &gt; or = 181.6 mg/mL.	Water	81-86	solute carrier family 17 member 5	Homo sapiens	64-67
15473549-8	2004	The concentrations of NO3- in the soil water show that the liberation of these elements from the solid phase is performed by HNO3.	Water	39-44	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
15557733-4	2004	This translocation enables the transepithelial reabsorption of water from the lumen to the interstitium via AQP2 at the apical membrane and AQP3/AQP4 at the basolateral membrane.	Water	63-68	aquaporin 3	Canis lupus familiaris	140-144
15557734-2	2004	The atomic structure of aquaporin-1 (AQP1) demonstrated how aquaporin is freely permeated by water but not protons and provided marked insight into several human disorders.	Water	93-98	aquaporin 1 (Colton blood group)	Homo sapiens	24-35
15557734-2	2004	The atomic structure of aquaporin-1 (AQP1) demonstrated how aquaporin is freely permeated by water but not protons and provided marked insight into several human disorders.	Water	93-98	aquaporin 1 (Colton blood group)	Homo sapiens	37-41
15646128-5	2004	The albumin-linked non-etherified fatty acids affected the ACE activity neither in water solutions nor in presence of lipoprotein complexes.	Water	83-88	angiotensin I converting enzyme	Homo sapiens	59-62
15491653-7	2004	When CL-20 was photolyzed in the presence of H2(18)O, D2O or 18O2 we obtained a product distribution suggesting that the energetic chemical degraded via at least two initial routes; one involved sequential homolysis of N-NO2 bond(s) and another involved photorearrangement prior to hydrolytic ring cleavage and decomposition in water.	Water	328-333	epithelial membrane protein 1	Homo sapiens	5-10
15476818-9	2004	Detailed comparison with other class I aldolase enzymes and DERA enzymes from different organisms reveals a similar geometric arrangement of key residues and implies a potential role for water as a general base in the catalytic mechanism.	Water	187-192	deoxyribose-phosphate aldolase	Homo sapiens	60-64
15356873-0	2004	Dynamics of water molecules buried in cavities of apolipoprotein E studied by molecular dynamics simulations and continuum electrostatic calculations.	Water	12-17	apolipoprotein E	Homo sapiens	50-66
15465057-6	2004	This describes a plausible role for the ring in operating a hydrophobic switch from within the aromatic cluster of helix 6 of rhodopsin, which is coupled to electronic changes within the receptor through water-mediated, hydrogen-bonded networks between the conserved residues in G protein-coupled receptors.	Water	204-209	rhodopsin	Homo sapiens	126-135
15450450-2	2004	Effect of bovine serum albumin (BSA) on water dissociation at the interface of a bipolar membrane.	Water	40-45	albumin	Homo sapiens	17-30
15450450-3	2004	This paper investigates the behavior of bovine serum albumin (BSA) during water dissociation on a bipolar membrane (BPM).	Water	74-79	albumin	Homo sapiens	47-60
15465300-0	2004	Enhanced stabilization of aerosol-OT surfactant monolayer upon interaction with small amounts of bovine serum albumin at the air-water interface.	Water	129-134	albumin	Homo sapiens	104-117
15465300-1	2004	An investigation is made of the influence from small amounts of the protein bovine serum albumin (BSA) on the lateral organization of low molecular weight surfactant sodium bis-2-ethylhexyl sulfosuccinate (AOT) at the air-water interface.	Water	222-227	albumin	Homo sapiens	83-96
15453699-4	2004	At 30% RH, 1-hexanol and hexanal were retained less than at 0% RH, indicating possible competition for binding sites on the SPI surface between water and volatile probe molecules.	Water	144-149	chromogranin A	Homo sapiens	124-127
15356873-1	2004	Molecular dynamics (MD) simulations of several nanoseconds each were used to monitor the dynamic behavior of the five crystal water molecules buried in the interior of the N-terminal domain of apolipoprotein E.	Water	126-131	apolipoprotein E	Homo sapiens	193-209
15356873-2	2004	These crystal water molecules are fairly well conserved in several apolipoprotein E structures, suggesting that they are not an artifact of the crystal and that they may have a structural and/or functional role for the protein.	Water	14-19	apolipoprotein E	Homo sapiens	67-83
15597081-9	2004	RESULTS: During the 2 hr after infusion, NPY yielded dose-dependent increases in both water and food consumption.	Water	86-91	neuropeptide Y	Rattus norvegicus	41-44
15597081-11	2004	Infusion of 1.0 microg of NPY in the absence of food yielded a decrease in water intake and an increase in ethanol intake relative to the same dose in the presence of food.	Water	75-80	neuropeptide Y	Rattus norvegicus	26-29
15511094-0	2004	Adsorption of polycyclic aromatic hydrocarbons at the air-water interface and its role in atmospheric deposition by fog droplets.	Water	58-63	zinc finger protein, FOG family member 1	Homo sapiens	116-119
15172884-1	2004	Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel.	Water	45-50	arginine vasopressin	Rattus norvegicus	0-11
15172884-1	2004	Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel.	Water	156-161	arginine vasopressin	Rattus norvegicus	0-11
15205186-9	2004	qAQP2 protein that binds to rabbit anti-rat AQP2 antibody is present in the apical/subapical regions of both cortical and medullary CDs from normally hydrated quail, and the intensity of staining increased only in the medullary CDs after water deprivation or AVT treatment.	Water	238-243	aquaporin 2 S homeolog	Xenopus laevis	1-5
15345336-1	2004	Hepatic glutathione content was measured and gene expression data were obtained using an Affymetrix RG U34 array after treatment with tap water containing 20mM l-buthionine (S, R)-sulfoximine (BSO) to male F344 rats for four consecutive days.	Water	138-143	nuclear RNA export factor 1	Rattus norvegicus	134-137
15071758-1	2004	The structures of the mammalian water transport protein Aqp1 and of its bacterial homologue GlpF enables us to test whether homology models can be used to explore relationships between structure, dynamics and function in mammalian transport proteins.	Water	32-37	aquaporin 1 (Colton blood group)	Homo sapiens	56-60
15071758-7	2004	The orientation of the dipoles of water molecules within the pore is of key importance in maintaining low proton permeability through Aqp1.	Water	34-39	aquaporin 1 (Colton blood group)	Homo sapiens	134-138
15511094-1	2004	This review addresses the significance of air-water interfacial adsorption in the fate and transport of polycyclic aromatic hydrocarbons (PAHs) in dispersed systems, such as fog droplets in the atmosphere and air bubbles in wastewater systems.	Water	46-51	zinc finger protein, FOG family member 1	Homo sapiens	174-177
15511094-3	2004	Specific cases where the air-water interfacial adsorption makes a significant impact, such as uptake of naphthalene by fog droplets in a falling droplet reactor and of pyrene removal on air bubbles in a solvent sublation reactor, are discussed as illustrations.	Water	29-34	zinc finger protein, FOG family member 1	Homo sapiens	119-122
15511094-4	2004	The consequence of the air-water interface in atmospheric wet deposition of PAHs by fog droplets is analyzed mathematically.	Water	27-32	zinc finger protein, FOG family member 1	Homo sapiens	84-87
15375773-7	2004	BK activates a G-protein coupled receptor, B2R, to regulate renal blood flow and salt and water excretion.	Water	90-95	kininogen 1	Homo sapiens	0-2
15549599-1	2004	The model system of poly(ethylene-oxide) or PEO, where the changing hydrogen-bond connectivity of the water has large effect on the conformation of the polymer chain, in mixtures of water and acetonitrile, is experimentally studied.	Water	102-107	twinkle mtDNA helicase	Homo sapiens	44-47
15549599-1	2004	The model system of poly(ethylene-oxide) or PEO, where the changing hydrogen-bond connectivity of the water has large effect on the conformation of the polymer chain, in mixtures of water and acetonitrile, is experimentally studied.	Water	182-187	twinkle mtDNA helicase	Homo sapiens	44-47
15549599-6	2004	Ions now no longer complex to PEO; instead, hydrogen bonding of water to the polymer strongly dictates conformation in this regime.	Water	64-69	twinkle mtDNA helicase	Homo sapiens	30-33
15205451-7	2004	IL-1beta-induced reduction in caffeine-induced peak Ca(2+) increase and contraction was reversed by catalase, suggesting a role of H(2)O(2).	Water	131-136	interleukin 1 beta	Homo sapiens	0-8
15500134-2	2004	All classic physiological effects of AII, such as vasoconstriction, aldosterone and vasopressin release, sodium and water retention and sympathetic facilitation, are mediated by the AT1 receptor.	Water	116-121	angiotensinogen	Homo sapiens	37-40
15458431-0	2004	Urinary excretion of aquaporin-2 water channel exaggerated dependent upon vasopressin in congestive heart failure.	Water	33-38	arginine vasopressin	Homo sapiens	74-85
15458431-2	2004	The present study was undertaken to determine whether urinary excretion of aquaporin-2 (AQP-2) water channel is exaggerated in patients with congestive heart failure dependent upon arginine vasopressin (AVP).	Water	95-100	arginine vasopressin	Homo sapiens	190-201
15458431-2	2004	The present study was undertaken to determine whether urinary excretion of aquaporin-2 (AQP-2) water channel is exaggerated in patients with congestive heart failure dependent upon arginine vasopressin (AVP).	Water	95-100	arginine vasopressin	Homo sapiens	203-206
15284836-3	2004	During a 12:12 light-dark cycle, as compared to control CHO cells, the implantation of encapsulated hANP-producing CHO cells was associated with an increase in the net excretion of water, sodium and potassium, and with a reversal of the advanced circadian phases related to renovascular hypertension in 2K1C rats.	Water	181-186	natriuretic peptide A	Homo sapiens	100-104
15382936-4	2004	When using a methanol:ethanol:water mixture (16:3:1) as the pressure-transmitting medium, two distinct compressibility regions are observed with a dramatic change in the compression mechanism at 4 GPa.	Water	30-35	glycophorin A (MNS blood group)	Homo sapiens	197-200
15379542-0	2004	Accelerated exchange of a buried water molecule in selectively disulfide-reduced bovine pancreatic trypsin inhibitor.	Water	33-38	trophoblast Kunitz domain protein 1	Bos taurus	99-116
15466236-13	2004	)OH produced by endogenous cell wall peroxidase in the presence of NADH and H(2)O(2).	Water	76-81	peroxidase 1	Zea mays	37-47
15350923-1	2004	A series of new metal complexes of Co(II), Ce(III) and UO(2)(VI), with the Schiff base ligand, H2L, bis-salicylatothiosemicarbazide have been prepared in presence of different molar ratios of LiOH.H2O as a deprotonating agent.	Water	197-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
15627710-2	2004	Water loss ratio of detached leaf of ATHK1-mutant was obviously higher than that of WT.	Water	0-5	histidine kinase 1	Arabidopsis thaliana	37-42
15226320-4	2004	Here we report the reconstitution of two water-insoluble SNARE proteins into GUVs without fusogenic additives.	Water	41-46	small NF90 (ILF3) associated RNA E	Homo sapiens	57-62
15341860-5	2004	Surface pressure Pi-A curves revealed that the amphiphilic triblock copolymer PEO-PPO-PEO molecule was flexible at the air/water interface.	Water	123-128	protoporphyrinogen oxidase	Homo sapiens	82-85
15366080-0	2004	[[[Pt(en)2][PtX2(en)2]]3][[(MX5)X3]2].12 H2O: quasi-one-dimensional halogen-bridged PtII-PtIV mixed-valence compounds with magnetic counteranions.	Water	41-44	paired like homeodomain 2	Homo sapiens	12-16
15366925-2	2004	Membrane preparations of unactivated (Rh) and light-activated rhodopsin (Rh*), each in the presence or absence of G(t)alpha(340-350), were acetylated with the water-soluble reagent sulfosuccinimidyl acetate, and the extent of the acetylation was determined by mass spectrometry.	Water	159-164	rhodopsin	Homo sapiens	73-76
15300159-5	2004	Analysis of the UT-A1 promoter suggests that vasopressin increases UT-A1 indirectly following a direct effect to increase the transcription of other genes, such as the Na(+)-K(+)-2Cl- cotransporter NKCC2/BSC1 and the aquaporin (AQP) 2 water channel, that begin to increase inner medullary osmolality.	Water	235-240	arginine vasopressin	Rattus norvegicus	45-56
16197850-1	2004	Central diabetes insipidus, is a syndrome characterized by the excretion of abnormally elevated volumes of diluted urine, due to the diminution of reabsorption of water in the collecting ducts, induced by the diminution of production of antidiuretic hormone.	Water	163-168	arginine vasopressin	Homo sapiens	237-257
15368571-3	2004	Glu181 and Ser186 form a network of hydrogen bonds mediated by a water molecule in the dark-state crystal structure of rhodopsin.	Water	65-70	rhodopsin	Homo sapiens	119-128
15336795-5	2004	Nitrate reduction was likely due to microbial degradation of accumulated organic matter coupled with successive consumption of O2 and NO3- in the macropore water followed by reductive dissolution of Fe and Mn from minerals along the macropores.	Water	156-161	NBL1, DAN family BMP antagonist	Homo sapiens	134-137
15693290-1	2004	OBJECTIVE: Magnocellular neuroendocrine cells of the supraoptic nucleus of the hypothalamus produce and release the hormones vasopressin and oxytocin in response to a variety of stimuli to regulate body water and salt as well as and parturition and lactation.	Water	203-208	arginine vasopressin	Rattus norvegicus	125-136
15288120-6	2004	The effect of the water-soluble trolox was due to chemical stabilization of the eNOS cofactor tetrahydrobiopterin.	Water	18-23	nitric oxide synthase 3	Homo sapiens	80-84
15593031-0	2004	Central role of vasopressin in sodium/water retention in hypo- and hypervolemic nephrotic patients: a unifying hypothesis.	Water	38-43	arginine vasopressin	Homo sapiens	16-27
15231853-0	2004	Interfacial properties of amphipathic beta strand consensus peptides of apolipoprotein B at oil/water interfaces.	Water	96-101	apolipoprotein B	Homo sapiens	72-88
15231853-7	2004	P12 and P27 are almost purely elastic on DD/W, TO/W, and air/water interfaces.	Water	61-66	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	0-3
15593031-4	2004	In the transition, a central role is played by vasopressin, which is secreted in the two phases, respectively, by a volume and an osmotic stimulus; therefore, persistent sodium/water retention is maintained through the vascular and tubular effects of this peptide.	Water	177-182	arginine vasopressin	Homo sapiens	47-58
15593031-5	2004	In addition, we propose that vasodilation and sodium/water excretion could ensue when both stimuli for vasopressin release fade away, leading to the resolution of the syndrome.	Water	53-58	arginine vasopressin	Homo sapiens	103-114
15338266-0	2004	Links between the structure of an Antarctic shallow-water community and ice-scour frequency.	Water	52-57	carboxylesterase 2	Homo sapiens	72-75
15301762-0	2004	Aquaporin water channels AQP1 and AQP3, are expressed in equine articular chondrocytes.	Water	10-15	aquaporin-1	Equus caballus	25-29
15301762-10	2004	AQP1 and AQP3 may be involved in the transport of water and small solutes and osmotically active metabolites across the chondrocyte plasma membrane during volume regulatory behaviour.	Water	50-55	aquaporin-1	Equus caballus	0-4
15301762-11	2004	AQP1 may be involved in transporting metabolic water.	Water	47-52	aquaporin-1	Equus caballus	0-4
15303915-6	2004	The mechanism for forming HCF(2) (+) involves the direct and rapid abstraction of a hydride ion from H(2)O by CF(2) (2+).	Water	101-106	host cell factor C2	Homo sapiens	26-32
15328060-10	2004	The exact local structure of the inner sphere Co(II) surface complexes, formed by exchanging the H(2)O ligands with surface oxygens, has been already approached but only for the surface planes of the alpha-Al(2)O(3) and rutile monocrystals.	Water	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
15317462-8	2004	Hydropathic analysis of the energetic contributions using HINT indicates a significant improvement of the correlation between HINT scores and the experimentally determined binding constants when the appropriate bridging water molecules are taken into account.	Water	220-225	histidine triad nucleotide binding protein 1	Homo sapiens	58-62
15317462-8	2004	Hydropathic analysis of the energetic contributions using HINT indicates a significant improvement of the correlation between HINT scores and the experimentally determined binding constants when the appropriate bridging water molecules are taken into account.	Water	220-225	histidine triad nucleotide binding protein 1	Homo sapiens	126-130
15317462-10	2004	HINT was shown to be able to map quantitatively the contribution of individual structural waters to binding energy.	Water	90-96	histidine triad nucleotide binding protein 1	Homo sapiens	0-4
15306382-5	2004	Water behaves like a reactant that competes with glucose in binding to hexokinase, and modulates its conformational change and activity.	Water	0-5	hexokinase 1	Homo sapiens	71-81
15460247-2	2004	For water samples, eight different solid-phase extraction (SPE) sorbents have been compared and among them, C18 provided highest recoveries and limits of detection of 0.3-15 ng/L.	Water	4-9	Bardet-Biedl syndrome 9	Homo sapiens	108-111
15446741-9	2004	The adsorption kinetics of Abeta to a DMPE monolayer followed by IRRAS (infrared reflection absorption spectroscopy) reveals the phase transition of DMPE molecules from liquid-expanded to condensed states at the same surface pressure as for DMPE on pure water.	Water	254-259	amyloid beta precursor protein	Homo sapiens	27-32
15446741-13	2004	In both cases, with lipids at surface pressures below 20 mNm(-1) and at the air-water interface, adsorbed Abeta has a beta-sheet conformation and these beta-sheets are oriented parallel to the interface.	Water	80-85	amyloid beta precursor protein	Homo sapiens	106-111
15219712-6	2004	Widespread intra- and inter-task correlations were evident, with impairment in all three water tasks (Morris maze, platform recognition, and radial arm water maze) correlating extensively with Abeta deposition in hippocampus and cerebral cortex.	Water	89-94	histocompatibility 2, class II antigen A, beta 1	Mus musculus	193-198
15219712-6	2004	Widespread intra- and inter-task correlations were evident, with impairment in all three water tasks (Morris maze, platform recognition, and radial arm water maze) correlating extensively with Abeta deposition in hippocampus and cerebral cortex.	Water	152-157	histocompatibility 2, class II antigen A, beta 1	Mus musculus	193-198
15281827-7	2004	For the saturated water layer ((2)/(3) ML) we find a stable structure with half the H(2)O dissociated (forming Pt-OH and Pt-H covalent bonds), which is less favorable by only 0.066 eV/water = 1.51 kcal/mol.	Water	18-23	parathyroid hormone	Homo sapiens	121-125
15274618-0	2004	FTIR spectroscopy of the K photointermediate of Neurospora rhodopsin: structural changes of the retinal, protein, and water molecules after photoisomerization.	Water	118-123	rhodopsin	Homo sapiens	59-68
15117728-4	2004	Finally, the contribution of ANG II-induced water drinking to the decrease in food intake was directly investigated.	Water	44-49	angiotensinogen	Rattus norvegicus	29-35
15068970-7	2004	Murine Oat5-expressing Xenopus laevis oocytes supported increased accumulation of the mycotoxin ochratoxin A, compared with water-injected control oocytes.	Water	124-129	solute carrier family 22 (organic anion transporter), member 19	Mus musculus	7-11
15272156-4	2004	This is the first time that a water molecule has been observed deep inside the ALR2 active site.	Water	30-35	aldo-keto reductase family 1 member B	Homo sapiens	79-83
15277036-5	2004	Plasma AVP levels were also increased by caloric stimulation with cold water.	Water	71-76	arginine vasopressin	Rattus norvegicus	7-10
15277241-1	2004	Glutathione transferase zeta (GSTZ1-1) is the major enzyme that catalyzes the metabolism of alpha-halo acids such as dichloroacetic acid, a carcinogenic contaminant of chlorinated water.	Water	180-185	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	Mus musculus	30-37
15039142-3	2004	When provided free access to water, PKC-alpha -/- mice showed approximately 50% greater urine flow rate and lower urinary osmolality in 24-h metabolic cage experiments despite a greater urinary vasopressin-to-creatinine ratio vs. PKC-alpha +/+ mice.	Water	29-34	protein kinase C, alpha	Mus musculus	36-45
15302659-8	2004	Furthermore, we determined whether intravenous injection of peritoneal exudate cells cultured with VIP overnight in vitro abrogated EAU.	Water	132-135	vasoactive intestinal polypeptide	Mus musculus	99-102
15271748-3	2004	For every 1 to 50-mg/dL increase in blood glucose concentration more than 100 mg/dL, 1 U of insulin was added to the injection port of a 100-mL measured volume set containing 5% dextrose in water.	Water	190-195	insulin	Homo sapiens	92-99
15284915-2	2004	A water-acetonitrile linear gradient on a C-18 reversed-phase column was found to be suitable in separating triamcinolone and its main derivatives, which greatly differ in lipophilicity.	Water	2-7	Bardet-Biedl syndrome 9	Homo sapiens	42-46
15302659-14	2004	In addition, VIP-treated peritoneal exudate cells generated regulator T cells in the spleens of recipient mice that were able to interfere with the development of EAU (control group mean score, 0.5; median score, 0.5; occurrence, 63% [n = 8]) compared with the VIP-treatment group (mean score, 0.08; median score, 0; occurrence, 17% [n = 6]) (P =.08).	Water	163-166	vasoactive intestinal polypeptide	Mus musculus	13-16
15460450-5	2004	SOD removes superoxide anions by converting them to H2O2, which can be rapidly converted to water by CAT and GPx.	Water	92-97	catalase	Rattus norvegicus	101-104
15298884-6	2004	In the latter case, an initial instability of GpA helices in water is reversed after the helices become surrounded by SDS.	Water	61-66	glycophorin A (MNS blood group)	Homo sapiens	46-49
15046923-6	2004	For plain PMM 2.1.2 microparticle in water (pH 5.5), the degree of deformation (a/R) on collagen coated substrate decreased from 0.77 to 0.26 against the increase of mid-plane diameter from 2 to 18 microm.	Water	37-42	phosphomannomutase 2	Mus musculus	10-15
15210339-1	2004	The glycosidic bond hydrolysis reaction of the enzyme uracil DNA glycosylase (UDG) occurs by a two-step mechanism involving complete bond breakage to the uracil anion leaving group in the first step, formation of a discrete glycosyl cation-uracil anion intermediate, followed by water attack in a second transition-state leading to the enzyme-bound products of uracil and abasic DNA.	Water	279-284	uracil DNA glycosylase	Homo sapiens	54-76
15210339-1	2004	The glycosidic bond hydrolysis reaction of the enzyme uracil DNA glycosylase (UDG) occurs by a two-step mechanism involving complete bond breakage to the uracil anion leaving group in the first step, formation of a discrete glycosyl cation-uracil anion intermediate, followed by water attack in a second transition-state leading to the enzyme-bound products of uracil and abasic DNA.	Water	279-284	uracil DNA glycosylase	Homo sapiens	78-81
15265033-8	2004	It is proposed that the surface-located and glycosylated N-terminal CP segments of intact PVX virions induce the formation of a columnar-type shell from bound water molecules around the virions, which probably play a major role in maintaining the virion surface structure.	Water	159-164	coat protein	Potato virus X	68-70
15265033-0	2004	N-Terminal segment of potato virus X coat protein subunits is glycosylated and mediates formation of a bound water shell on the virion surface.	Water	109-114	coat protein	Potato virus X	37-49
15185331-7	2004	The efficiency of the method is tested by calculations of SPC/E model of water.	Water	73-78	proline rich protein gene cluster	Homo sapiens	58-61
15518173-0	2004	Inhibitory effect of water-soluble chitosan on TNF-alpha and IL-8 secretion from HMC-1 cells.	Water	21-26	tumor necrosis factor	Homo sapiens	47-56
15518173-0	2004	Inhibitory effect of water-soluble chitosan on TNF-alpha and IL-8 secretion from HMC-1 cells.	Water	21-26	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15359580-4	2004	An excess of triacetin was added to the emulsion so that water could be extracted into the continuous phase, allowing the insulin-loaded microsphere precipitation.	Water	57-62	insulin	Homo sapiens	122-129
15359580-10	2004	CONCLUSIONS: The water extraction procedures successfully produced insulin-loaded hydrophilic microspheres allowing the preservation of peptide stability.	Water	17-22	insulin	Homo sapiens	67-74
15172840-1	2004	In large trees, the daily onset of transpiration causes water to be withdrawn from internal storage compartments, resulting in lags between changes in transpiration and sap flow at the base of the tree.	Water	56-61	SH2 domain containing 1A	Homo sapiens	169-172
15300217-1	2004	BACKGROUND: Endothelin-1 (ET-1) decreases water efflux across the endothelial barrier (Lp).	Water	42-47	endothelin 1	Homo sapiens	12-24
15300217-1	2004	BACKGROUND: Endothelin-1 (ET-1) decreases water efflux across the endothelial barrier (Lp).	Water	42-47	endothelin 1	Homo sapiens	26-30
15276738-2	2004	In the MBR, NO3(-) contaminated water flows through the lumen of tubular microporous membranes and NO3(-) diffuses through the membrane pores.	Water	32-37	NBL1, DAN family BMP antagonist	Homo sapiens	12-15
15123612-7	2004	Both proton ((1)H) and nitrogen ((14)N) ENDOR studies of bSOD1 and hSOD1 in the presence of H(2)O(2) revealed a change in the geometry of His-46 (or His-44) and His-48 (or His-46) coordinated to Cu(II) at the active site of WT hSOD1 and bSOD1, respectively.	Water	92-97	superoxide dismutase 1	Homo sapiens	67-72
15123612-7	2004	Both proton ((1)H) and nitrogen ((14)N) ENDOR studies of bSOD1 and hSOD1 in the presence of H(2)O(2) revealed a change in the geometry of His-46 (or His-44) and His-48 (or His-46) coordinated to Cu(II) at the active site of WT hSOD1 and bSOD1, respectively.	Water	92-97	superoxide dismutase 1	Homo sapiens	227-232
15178276-0	2004	Expulsion of bovine serum albumin from the air/water interface by a sparingly soluble lecithin lipid.	Water	47-52	albumin	Homo sapiens	20-33
15152000-9	2004	The changes in the water network and the allosteric core explain the thermodynamic signatures linked to Na(+) binding and the mechanism of thrombin activation by Na(+).	Water	19-24	coagulation factor II, thrombin	Homo sapiens	139-147
15152000-10	2004	The role of the water network uncovered in this study establishes a new paradigm for the allosteric regulation of thrombin and other Na(+)-activated enzymes involved in blood coagulation and the immune response.	Water	16-21	coagulation factor II, thrombin	Homo sapiens	114-122
15194214-0	2004	Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivatives.	Water	93-98	gap junction protein, alpha 1	Mus musculus	16-27
15263953-1	2004	The formation constants of the ligand N,N,N",N"-tetrakis(carbamoylmethyl)-ethylenediamine suggest that the amide oxygen is a stronger Lewis base in water than the alcoholic oxygen, or water, and that part of the selectivity for Ca2+ over Mg2+ shown by calcium-binding proteins such as calmodulin or annexin may be due to the higher affinity of Ca2+ for the O-donor of the Ca-binding amide groups present in such proteins.	Water	148-153	calmodulin 1	Homo sapiens	285-295
15223330-7	2004	The serine/histidine juxtaposition to a threonine residue and a carbonyl oxygen atom, along with conservation of the catalytic water molecule found in PGRP-LB, tantalizingly suggests some hydrolytic function for this member of receptor PGRPs.	Water	127-132	Peptidoglycan recognition protein LB	Drosophila melanogaster	151-158
15238002-6	2004	Water adsorption measurements for Ac-V(n)K+H(+) and Ac-L(n)K+H(+) with n = 5-10 suggest that the helix emerges at n = 8 for these peptides as well.	Water	0-5	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	34-38
15231996-7	2004	Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis.	Water	10-15	arginine vasopressin	Rattus norvegicus	54-57
15231996-7	2004	Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis.	Water	10-15	arginine vasopressin	Rattus norvegicus	103-106
15231996-7	2004	Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis.	Water	10-15	arginine vasopressin	Rattus norvegicus	103-106
15231996-7	2004	Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis.	Water	10-15	arginine vasopressin	Rattus norvegicus	103-106
15240742-10	2004	In mice adoptively transferred spleen cells from hIRBP 1-20-immunized mice, EAU was also suppressed by injection of CGRP-treated PEC.	Water	76-79	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	116-120
15240742-11	2004	EAU was markedly inhibited in hIRBP 1-20-immunized mice adoptively transferred T cells obtained from mice injected with hIRBP 1-20-pulsed, CGRP-treated PEC.	Water	0-3	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	139-143
15252589-6	2004	The hydration states of the europium complexes were measured by luminescence and show the coordination of 4-5 water ligands in [Eu(tpa)]3+ whereas there are only 2 in [Eu(tpaam)]3+.	Water	110-115	plasminogen activator, tissue type	Homo sapiens	131-134
15252589-7	2004	Therefore the heptadentate ligand tpaam releases the translational entropy of more water molecules than does the tetradentate ligand tpa.	Water	83-88	plasminogen activator, tissue type	Homo sapiens	34-37
15211447-1	2004	BACKGROUND: Aquaporin 1 (AQP-1) channels have been claimed to be responsible for osmotically driven free-water movement across the peritoneal membrane.	Water	105-110	aquaporin 1 (Colton blood group)	Homo sapiens	12-23
16459590-4	2004	Localization of PPOMA inside the mixed micelles is considered (i) using 1H NMR to localize the methacrylate function at the hydrophobic core-water interface and (ii) by studying the SDS-PPO micellar system (whose M(w) = 400 g x mol(-1)).	Water	141-146	protoporphyrinogen oxidase	Homo sapiens	16-19
15211447-1	2004	BACKGROUND: Aquaporin 1 (AQP-1) channels have been claimed to be responsible for osmotically driven free-water movement across the peritoneal membrane.	Water	105-110	aquaporin 1 (Colton blood group)	Homo sapiens	25-30
15211447-2	2004	Data about AQP-1 expression and its location in the human peritoneum related to clinical findings concerning ultrafiltration (UF) and free-water transport are still lacking.	Water	139-144	aquaporin 1 (Colton blood group)	Homo sapiens	11-16
15211447-8	2004	Free-water transport through AQP-1 was 42% +/- 12% from total UF after 1 hour.	Water	5-10	aquaporin 1 (Colton blood group)	Homo sapiens	29-34
15211447-9	2004	There was a significant correlation between AQP-1 expression and free-water transport after 1 hour of equilibration with 3.86% glucose in the PET (r = 0.753; P &lt; 0.001).	Water	70-75	aquaporin 1 (Colton blood group)	Homo sapiens	44-49
15211447-11	2004	AQP-1 expression correlated with free-water transport after 1 hour of equilibration, reaching a significant part from total UF at this time.	Water	38-43	aquaporin 1 (Colton blood group)	Homo sapiens	0-5
15068976-7	2004	Water restriction resulted in an increase in UT-B expression in ureters (49%, P = 0.001) but not in bladders (14%, P = not significant).	Water	0-5	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	45-49
15135229-1	2004	Three water channel proteins, aquaporins, have been shown to be expressed in the placentae of humans and sheep-AQP1, 3, 8; AQP1 is in the vasculature, whereas AQP3, 8 are in the trophoblast cells.	Water	6-11	aquaporin 1 (Colton blood group)	Homo sapiens	111-115
15370369-0	2004	Topical administration of iganidipine, a new water-soluble Ca2+ antagonist, increases ipsilateral optic nerve head circulation in rabbits and cynomolgus monkeys.	Water	45-50	carbonic anhydrase 2	Oryctolagus cuniculus	59-62
15207533-7	2004	The results in this study suggested that lysozyme, processed by freeze-drying, is stabilised primarily by the water substitution mechanism.	Water	110-115	lysozyme	Homo sapiens	41-49
15213263-7	2004	These results suggest that At1a receptor-mediated inputs play critical roles in maintaining renal vascular eNOS expression and activity during changes in salt-water balance and systemic BP.	Water	159-164	angiotensin II receptor, type 1a	Mus musculus	27-31
15307904-9	2004	Moreover, the water content on days 1, 3, and 7 was significantly reduced and macrophage infiltration on days 3 and 7 was dramatically reduced in the PP1 group.	Water	14-19	neuropeptide Y receptor Y4	Rattus norvegicus	150-153
15981592-4	2004	This FTIR spectroscopic imaging in the ATR mode provides novel insight into the mechanism of dissolution of nifedipine from solid dispersions in water-soluble polymers, which is valuable in optimization of manufacturing these formulations.	Water	145-150	ATR serine/threonine kinase	Homo sapiens	39-42
15208000-0	2004	Comparison of t-PA and u-PA levels in maximal treadmill and deep-water running.	Water	65-70	plasminogen activator, tissue type	Homo sapiens	14-18
15208000-0	2004	Comparison of t-PA and u-PA levels in maximal treadmill and deep-water running.	Water	65-70	plasminogen activator, urokinase	Homo sapiens	23-27
15208000-2	2004	The purpose of this investigation was to compare u-PA and t-PA levels during maximal treadmill and deep-water running.	Water	104-109	plasminogen activator, urokinase	Homo sapiens	49-53
15208000-2	2004	The purpose of this investigation was to compare u-PA and t-PA levels during maximal treadmill and deep-water running.	Water	104-109	plasminogen activator, tissue type	Homo sapiens	58-62
15213829-3	2004	To improve their fluorescence intensity and stability in water solution, bovine serum albumin (BSA) was absorbed onto their surface.	Water	57-62	albumin	Homo sapiens	80-93
15159202-4	2004	However, in environments where prolonged fogging occurs water droplets form on anti-fog coated lenses which disrupts visual performance in a manner similar to the fog it is trying to prevent.	Water	56-61	zinc finger protein, FOG family member 1	Homo sapiens	41-44
15159202-4	2004	However, in environments where prolonged fogging occurs water droplets form on anti-fog coated lenses which disrupts visual performance in a manner similar to the fog it is trying to prevent.	Water	56-61	zinc finger protein, FOG family member 1	Homo sapiens	84-87
15044362-6	2004	Replacement of corticosterone in the drinking water of ADX rats reversed the effects of ADX on MCH sensitivity.	Water	46-51	oleoyl-ACP hydrolase	Rattus norvegicus	95-98
15020581-4	2004	Addition of doxycycline to the drinking water of CC10-rtTA-NOS-2 mice causes an increase in nitric oxide synthase-2 that is largely confined to the airway epithelium.	Water	40-45	nitric oxide synthase 2, inducible	Mus musculus	59-64
15020581-4	2004	Addition of doxycycline to the drinking water of CC10-rtTA-NOS-2 mice causes an increase in nitric oxide synthase-2 that is largely confined to the airway epithelium.	Water	40-45	nitric oxide synthase 2, inducible	Mus musculus	92-115
15237289-0	2004	Bio-analytical and chemical characterisation of offshore produced water effluents for estrogen receptor (ER) agonists.	Water	66-71	estrogen receptor 1	Homo sapiens	86-103
15237289-0	2004	Bio-analytical and chemical characterisation of offshore produced water effluents for estrogen receptor (ER) agonists.	Water	66-71	estrogen receptor 1	Homo sapiens	105-107
15237289-6	2004	The observed poor correlation of the alkylphenol isomer content and ER agonist activity suggests that other compounds present in the produced water discharges may be responsible for the ER agonist activity observed.	Water	142-147	estrogen receptor 1	Homo sapiens	186-188
15135229-1	2004	Three water channel proteins, aquaporins, have been shown to be expressed in the placentae of humans and sheep-AQP1, 3, 8; AQP1 is in the vasculature, whereas AQP3, 8 are in the trophoblast cells.	Water	6-11	aquaporin-3	Ovis aries	159-163
15296798-10	2004	RESULTS: Seated SBP and DBP increased after water instillation with increases first noted between 5 and 8 min after the water had been instilled.	Water	44-49	D-box binding PAR bZIP transcription factor	Homo sapiens	24-27
15212549-2	2004	Two different protein cavities, in bovine pancreatic trypsin inhibitor (BPTI) and in the I76A mutant of barnase, represent very different environments for the water molecule: one which is polar, forming four water-protein hydrogen bonds, and one which is more hydrophobic, forming only one water-protein hydrogen bond.	Water	159-164	trophoblast Kunitz domain protein 1	Bos taurus	53-70
15296798-11	2004	The BP remained elevated until 35 min post water increase over baseline being +36.5 mm Hg SBP and +24.3 mm Hg DBP.	Water	43-48	D-box binding PAR bZIP transcription factor	Homo sapiens	110-113
15037626-1	2004	Arginine vasopressin (AVP) increases the water permeability of renal collecting duct principal cells by inducing the fusion of vesicles containing the water channel aquaporin-2 (AQP2) with the plasma membrane (AQP2 shuttle).	Water	41-46	arginine vasopressin	Homo sapiens	9-20
15986674-7	2004	Furthermore, we show that for the lowest molecular weights, PSS adsorbs with C12TAB in compact layers at the air-water interface.	Water	113-118	PSS	Homo sapiens	60-63
15245031-1	2004	The phase diagram of water as obtained from computer simulations is presented for the first time for two of the most popular models of water, TIP4P and SPC/E.	Water	21-26	proline rich protein gene cluster	Homo sapiens	152-155
15170322-1	2004	Glutamic acid E134 in rhodopsin is part of a highly conserved triad, D(E)RY, located near the cytoplasmic lipid/water interface in transmembrane helix 3 of G protein-coupled receptors (GPCRs).	Water	112-117	rhodopsin	Homo sapiens	22-31
21232217-6	2004	CONCLUSIONS: Aquaporin 3 and aquaporin 5 express in SPC-A-1 cell, and their roles in water transport of SPC-A-1 cell should be further investigated.	Water	85-90	proline rich protein gene cluster	Homo sapiens	104-107
15170322-13	2004	This sensitivity together with the location of E134 near the actual position of the lipid/water interface could be a strategic element in the mechanism of activation of rhodopsin.	Water	90-95	rhodopsin	Homo sapiens	169-178
15161302-5	2004	For example, in the presence of 0.20 M Na(+) and 0.56 M Rb(+) at 4 degrees C, the ApT site in the minor groove is occupied by a Rb(+) ion, a Na(+) ion, or a water molecule 40, 10, and 50% of the time, respectively.	Water	157-162	LYPLA2 pseudogene 1	Homo sapiens	82-85
15135654-2	2004	The water extract of P. urinaria induced the apoptosis of HL-60 cells as demonstrated by morphological change, DNA fragmentation and increased caspase-3 activity.	Water	4-9	caspase 3	Homo sapiens	143-152
15189869-1	2004	The hydrophobic proteins SP-B and SP-C promote rapid adsorption of pulmonary surfactant to an air/water interface by an unknown mechanism.	Water	98-103	surfactant protein B	Bos taurus	25-29
15167778-3	2004	Two distinct p-xylene and water environments were identified within the C18-bonded silica through the measurement of (1)H NMR chemical shifts, T(1) and T(2) relaxation times and diffusion coefficients, including their temperature dependence.	Water	26-31	Bardet-Biedl syndrome 9	Homo sapiens	72-75
15150578-6	2004	[(18)F]FETA, with an octanol-water partition coefficient of 0.16+/-0.01, was selectively retained by RIF-1 cells under hypoxia compared to air (3.4- to 4.3-fold at 60-120 min).	Water	29-34	replication timing regulatory factor 1	Mus musculus	101-106
15148276-1	2004	BACKGROUND: Arginine vasopressin (AVP) is a vasoactive hormone that acts on the kidney to conserve solute-free water and produces a potent vasoconstrictive effect during hypovolemic states.	Water	111-116	arginine vasopressin	Homo sapiens	12-32
15171994-4	2004	Corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) that regulate a variety of physiological processes including the hypothalamic-pituitary-adrenal axis (HPA axis), energy and water homeostasis were used as model systems.	Water	192-197	corticotropin releasing hormone	Rattus norvegicus	0-30
15171994-4	2004	Corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) that regulate a variety of physiological processes including the hypothalamic-pituitary-adrenal axis (HPA axis), energy and water homeostasis were used as model systems.	Water	192-197	arginine vasopressin	Rattus norvegicus	50-61
15081765-1	2004	In the present study electrocoagulation (EC) has been evaluated as a treatment technology for arsenite [As(III)] and arsenate [As(V)] removal from water.	Water	147-152	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	126-132
15158685-9	2004	Snail control using environmental modification should focus on controlling these plants in human-water contact sites.	Water	97-102	snail family transcriptional repressor 1	Homo sapiens	0-5
15148276-1	2004	BACKGROUND: Arginine vasopressin (AVP) is a vasoactive hormone that acts on the kidney to conserve solute-free water and produces a potent vasoconstrictive effect during hypovolemic states.	Water	111-116	arginine vasopressin	Homo sapiens	34-37
15099578-5	2004	Finally, we applied the rules ascertained in the previous steps to separate freeze-fracture images of the cytoplasmic and external domains of the small (approximately 118 kDa) aquaporin-0 water channel.	Water	188-193	major intrinsic protein of lens fiber	Homo sapiens	176-187
15463893-9	2004	CONCLUSIONS: Loss of CFTR and CFTR-driven autocrine ATP signaling may underlie defective cell volume regulation and dysregulated ion, water, and acid-base transport in CF airway epithelia.	Water	134-139	CF transmembrane conductance regulator	Homo sapiens	21-25
15463893-9	2004	CONCLUSIONS: Loss of CFTR and CFTR-driven autocrine ATP signaling may underlie defective cell volume regulation and dysregulated ion, water, and acid-base transport in CF airway epithelia.	Water	134-139	CF transmembrane conductance regulator	Homo sapiens	30-34
15244569-2	2004	For a water fog generated with a 1.75 MHz piezoelectric driver below the liquid surface, the 7 microm diameter droplets are found to have diffusive dynamics for correlation times long compared to the viscous time.	Water	6-11	zinc finger protein, FOG family member 1	Homo sapiens	12-15
15169887-6	2004	Catalase, an H(2)O(2) scavenger, strongly suppresses LMP1-induced production of H(2)O(2), which results in a decrease in the expression of HIF-1 alpha induced by LMP1.	Water	13-18	catalase	Homo sapiens	0-8
15169887-6	2004	Catalase, an H(2)O(2) scavenger, strongly suppresses LMP1-induced production of H(2)O(2), which results in a decrease in the expression of HIF-1 alpha induced by LMP1.	Water	13-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-150
15169887-6	2004	Catalase, an H(2)O(2) scavenger, strongly suppresses LMP1-induced production of H(2)O(2), which results in a decrease in the expression of HIF-1 alpha induced by LMP1.	Water	80-85	catalase	Homo sapiens	0-8
15169887-6	2004	Catalase, an H(2)O(2) scavenger, strongly suppresses LMP1-induced production of H(2)O(2), which results in a decrease in the expression of HIF-1 alpha induced by LMP1.	Water	80-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-150
15203246-5	2004	Subsequently Orexin-A was found to impair both water maze performance and hippocampal long term potentiation (LTP).	Water	47-52	hypocretin neuropeptide precursor	Rattus norvegicus	13-21
15244587-2	2004	The latter was achieved on the surface of water by spreading a binary mixture composed of two solutions: nitrocellulose dissolved in amyl acetate and Co Pt3 particles stabilized by hexadecylamine dissolved in hexane.	Water	42-47	zinc finger protein 135	Homo sapiens	153-156
15147807-1	2004	Formulation optimization of the water-in-oil-in-water multiple emulsion incorporating insulin was performed based on statistical methods such as the orthogonal experimental design and the response surface evaluation.	Water	32-37	insulin	Homo sapiens	86-93
15152084-6	2004	Our results indicate that the fluorescence of AW of hirudin 1-47 in the Y3AW-thrombin complex is strongly quenched, possibly because of the presence of two structural water molecules at the hirudin-thrombin interface that can promote the nonradiative decay of AW in the excited state.	Water	167-172	coagulation factor II, thrombin	Homo sapiens	77-85
15152084-6	2004	Our results indicate that the fluorescence of AW of hirudin 1-47 in the Y3AW-thrombin complex is strongly quenched, possibly because of the presence of two structural water molecules at the hirudin-thrombin interface that can promote the nonradiative decay of AW in the excited state.	Water	167-172	coagulation factor II, thrombin	Homo sapiens	198-206
15146490-1	2004	Structural properties of water inside bovine aquaporin-1 are investigated by molecular simulation.	Water	25-30	aquaporin 1	Bos taurus	45-56
15147807-1	2004	Formulation optimization of the water-in-oil-in-water multiple emulsion incorporating insulin was performed based on statistical methods such as the orthogonal experimental design and the response surface evaluation.	Water	48-53	insulin	Homo sapiens	86-93
15106969-2	2004	However, Co(III) can bind water far more strongly than Co(II) as a sixth ligand, so that the competition between water and NO complexation strongly favors water for Co(III) in the gas phase.	Water	26-31	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	9-16
15151697-9	2004	CNTF-specific physiologic effects of a decrease in weight and water intake were obtained.	Water	62-67	ciliary neurotrophic factor	Rattus norvegicus	0-4
15003832-0	2004	Effects of angiotensin and vasopressin V(1) receptors on water and sodium intake induced by injection of vasopressin into lateral septal area.	Water	57-62	arginine vasopressin	Rattus norvegicus	105-116
15003832-5	2004	Water and sodium intake were measured at 0.25, 0.5, 1.0 and 2.0 h. Injection of AVP reduced the water and sodium ingestion vs. control (0.15 M saline).	Water	0-5	arginine vasopressin	Rattus norvegicus	80-83
15003832-5	2004	Water and sodium intake were measured at 0.25, 0.5, 1.0 and 2.0 h. Injection of AVP reduced the water and sodium ingestion vs. control (0.15 M saline).	Water	96-101	arginine vasopressin	Rattus norvegicus	80-83
14757771-3	2004	Here, we will provide evidence that GroEL is rather insensitive to oxidants produced endogenously during metabolism, such as nitric oxide (.NO) or hydrogen peroxide (H(2)O(2)), but is modified and inactivated by efficiently reactive species generated by phagocytes, such as peroxynitrite (ONOO(-)) and hypochlorous acid (HOCl).	Water	166-171	GroEL	Escherichia coli	36-41
15064139-12	2004	When tested 24 h following water-restraint stress, animals with increased 5-HT(1B) autoreceptors demonstrated restoration of robust FPS response.	Water	27-32	5-hydroxytryptamine receptor 1B	Homo sapiens	74-81
15106988-6	2004	The Pb(II) ion in 1 has an average Pb-N = 2.63 A to four N-donors from the macrocyclic ring, and four O-donors (average Pb-O = 2.77 A) from the amide pendant donors of the macrocycle, with a water molecule placed with Pb-O = 3.52 A above the proposed site of the lone pair (Lp) on Pb.	Water	191-196	submaxillary gland androgen regulated protein 3B	Homo sapiens	4-10
15106988-9	2004	A water situated 3.52 A above the proposed site of the lone pair on Pb(II) in 1 is oriented in such a way that it might be thought to be forming a Pb-Lp.H-O-H hydrogen bond.	Water	2-7	submaxillary gland androgen regulated protein 3B	Homo sapiens	68-74
15106969-2	2004	However, Co(III) can bind water far more strongly than Co(II) as a sixth ligand, so that the competition between water and NO complexation strongly favors water for Co(III) in the gas phase.	Water	26-31	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	165-172
15106969-2	2004	However, Co(III) can bind water far more strongly than Co(II) as a sixth ligand, so that the competition between water and NO complexation strongly favors water for Co(III) in the gas phase.	Water	113-118	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	9-16
15106969-2	2004	However, Co(III) can bind water far more strongly than Co(II) as a sixth ligand, so that the competition between water and NO complexation strongly favors water for Co(III) in the gas phase.	Water	113-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
15106969-2	2004	However, Co(III) can bind water far more strongly than Co(II) as a sixth ligand, so that the competition between water and NO complexation strongly favors water for Co(III) in the gas phase.	Water	113-118	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	165-172
15106969-2	2004	However, Co(III) can bind water far more strongly than Co(II) as a sixth ligand, so that the competition between water and NO complexation strongly favors water for Co(III) in the gas phase.	Water	113-118	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	9-16
15106969-2	2004	However, Co(III) can bind water far more strongly than Co(II) as a sixth ligand, so that the competition between water and NO complexation strongly favors water for Co(III) in the gas phase.	Water	113-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
15106969-2	2004	However, Co(III) can bind water far more strongly than Co(II) as a sixth ligand, so that the competition between water and NO complexation strongly favors water for Co(III) in the gas phase.	Water	113-118	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	165-172
15106969-3	2004	Although the Co(II) oxidation state is found to bind water slightly more strongly than NO in the gas phase, the inclusion of solvation effects via the polarizeable continuum model makes NO binding more favorable.	Water	53-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
15110946-7	2004	The aqua Co(II) complex must be the reactive catalytic species in the catalyzed dehydration reaction and the rate-determining step is the substitution of the labile water molecule by HCO3-.	Water	165-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
15068965-2	2004	Sympathetic nervous and renin-angiotensin-aldosterone system activation appear to play an important role in the sodium and water retention, rightward shift in the pressure-natriuresis, and blood pressure elevation observed in obese individuals.	Water	123-128	renin	Homo sapiens	24-29
15132699-6	2004	Further, incorporating chitin whisker into the SPI matrix leads to an improvement in water resistance for the SPI based nanocomposites.	Water	85-90	chromogranin A	Homo sapiens	47-50
15132699-6	2004	Further, incorporating chitin whisker into the SPI matrix leads to an improvement in water resistance for the SPI based nanocomposites.	Water	85-90	chromogranin A	Homo sapiens	110-113
15137089-1	2004	Sonic absorption spectra of solutions of human serum albumin (SA) in water and in aqueous phosphate buffer systems have been measured between 0.2 and 2000 MHz at different temperatures (15-35 degrees C), pH values (1.8-12.3), and protein concentrations (1-40 g/L).	Water	69-74	albumin	Homo sapiens	47-60
15141214-0	2004	Aquaporin-0 membrane junctions reveal the structure of a closed water pore.	Water	64-69	major intrinsic protein of lens fiber	Homo sapiens	0-11
15141214-1	2004	The lens-specific water pore aquaporin-0 (AQP0) is the only aquaporin known to form membrane junctions in vivo.	Water	18-23	major intrinsic protein of lens fiber	Homo sapiens	29-40
15141214-1	2004	The lens-specific water pore aquaporin-0 (AQP0) is the only aquaporin known to form membrane junctions in vivo.	Water	18-23	major intrinsic protein of lens fiber	Homo sapiens	42-46
15141214-5	2004	Whereas all previously determined aquaporin structures show the pore in an open conformation, the water pore is closed in AQP0 junctions.	Water	98-103	major intrinsic protein of lens fiber	Homo sapiens	122-126
15141214-6	2004	The water pathway in AQP0 also contains an additional pore constriction, not seen in other known aquaporin structures, which may be responsible for pore gating.	Water	4-9	major intrinsic protein of lens fiber	Homo sapiens	21-25
15100356-4	2004	Fluorescence-based real-time reverse transcription-PCR and Northern blot analysis showed upregulation of the UT-A2 urea transporter and the aquaporin 2 (AQP2) and AQP3 water channel transcripts but no change in other urea transporters or AQP.	Water	168-173	aquaporin 3	Mus musculus	163-167
15115689-9	2004	The IL-6 response was produced by the non-adherent cellular population, which made 4912 pg/ml IL-6 when treated with water soluble extract at 1 mg/ml.	Water	117-122	interleukin 6	Mus musculus	4-8
15115689-9	2004	The IL-6 response was produced by the non-adherent cellular population, which made 4912 pg/ml IL-6 when treated with water soluble extract at 1 mg/ml.	Water	117-122	interleukin 6	Mus musculus	94-98
15115689-10	2004	Likewise, the water soluble extract of Echinacea was able to stimulate non-adherent splenocyte populations to produce TNF-alpha (2082 pg/ml), IL-10 (892 pg/ml) and MIP-1alpha (6486 pg/ml) from non-adherent splenocytes, but only significant concentrations of TNF-alpha and MIP-1alpha mediators were produced from adherent populations at similar dose concentrations.	Water	14-19	tumor necrosis factor	Mus musculus	118-127
15115689-10	2004	Likewise, the water soluble extract of Echinacea was able to stimulate non-adherent splenocyte populations to produce TNF-alpha (2082 pg/ml), IL-10 (892 pg/ml) and MIP-1alpha (6486 pg/ml) from non-adherent splenocytes, but only significant concentrations of TNF-alpha and MIP-1alpha mediators were produced from adherent populations at similar dose concentrations.	Water	14-19	interleukin 10	Mus musculus	142-147
15115689-10	2004	Likewise, the water soluble extract of Echinacea was able to stimulate non-adherent splenocyte populations to produce TNF-alpha (2082 pg/ml), IL-10 (892 pg/ml) and MIP-1alpha (6486 pg/ml) from non-adherent splenocytes, but only significant concentrations of TNF-alpha and MIP-1alpha mediators were produced from adherent populations at similar dose concentrations.	Water	14-19	tumor necrosis factor	Mus musculus	258-267
14752105-8	2004	The activated TGase 2 catalyzed the formation of water-insoluble dimers or polymers of alphaB-crystallin, betaB(2)-crystallin, and vimentin in HLE-B3 cells, providing evidence that TGase 2 may play a role in cataractogenesis.	Water	49-54	transglutaminase 2	Homo sapiens	14-21
15224936-3	2004	The aim of the present study is to identify the hydrological conditions under which the weathered schist ground water influences the stream water chemistry, leading to a decrease in NO3- concentration.	Water	112-117	NBL1, DAN family BMP antagonist	Homo sapiens	182-185
15224936-3	2004	The aim of the present study is to identify the hydrological conditions under which the weathered schist ground water influences the stream water chemistry, leading to a decrease in NO3- concentration.	Water	140-145	NBL1, DAN family BMP antagonist	Homo sapiens	182-185
15224936-5	2004	Using SO4/2- as a tracer of the weathered schist ground water, we showed that ground water inflow caused a decrease of NO3- concentration in the stream during the autumn as well as during storm events in spring and summer.	Water	85-90	NBL1, DAN family BMP antagonist	Homo sapiens	119-122
15224936-6	2004	In summer, the NO3- concentration was controlled by the sources of the stream, and in winter by the shallow ground water inflow.	Water	115-120	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
15224936-7	2004	The effect of the weathered schist ground water on the NO3- depletion remained relatively limited in time.	Water	42-47	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
15224936-8	2004	This effect persisted into late autumn as long as the NO3(-) -rich shallow ground water did not feed the stream.	Water	82-87	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
15134917-2	2004	In 10% methanol/water, the one-electron reduction of quinones L1 and L2 to the corresponding semiquinones is shifted to more positive potentials upon addition of one equivalent of Zn(II), Ni(II), Co(II) or Cd(II) and is consistent with formation of a 1:1 complex involving the quinone(N) and adjacent quinone(O).	Water	16-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
17200614-9	2004	Our results strongly suggest that the IFN-inducible RNase L is induced by a broad range of stress-inducing signals such as double-stranded RNA (dsRNA) produced during viral infection, membrane- and osmotic shock caused by CaCl(2) and oxidative stress induced by H(2)O(2), inflammation stimulated by TNF-alpha and chemotherapy.	Water	262-268	interferon alpha 1	Homo sapiens	38-41
18969381-5	2004	However, the enhancement effect saturates at about 4muM Fe(3+), so that reliable results can be obtained if the water sample is supplemented with Fe(3+) to reach this level.	Water	112-117	latexin	Homo sapiens	52-55
15078916-9	2004	Alkaline pH increased the water permeability of AQP4 that contains His at position 129 in loop C. Acid and alkaline pH sensitivity was induced in AQP1 by adding histidines 48 (in loop A) and 130 (in loop C).	Water	26-31	aquaporin 1	Bos taurus	146-150
15170745-5	2004	Formation of [b(3) - 1 + Cat](+) from the alkali metal cationized versions was not a favorable process upon suppression or elimination of the [b(3) + 17 + Cat](+) pathway: the loss of H(2)O to form [M - H(2)O + Cat](+) was instead the dominant dissociation reaction observed.	Water	184-189	catalase	Homo sapiens	25-28
14761966-12	2004	Immunoblotting analysis of cyt c after exposure to NO in the presence of H(2)O(2) revealed the formation of 3-nitrotyrosine.	Water	73-78	cytochrome c, somatic	Homo sapiens	27-32
15050431-1	2004	Epidemiologic studies of endemic foci of amyotrophic lateral sclerosis (ALS) have shown low concentrations of Ca/Mg and high concentrations of Al/Mn in the drinking water and garden soil, which may play a causative role in the pathogenesis of endemic ALS.	Water	165-170	superoxide dismutase 1	Homo sapiens	72-75
14752105-8	2004	The activated TGase 2 catalyzed the formation of water-insoluble dimers or polymers of alphaB-crystallin, betaB(2)-crystallin, and vimentin in HLE-B3 cells, providing evidence that TGase 2 may play a role in cataractogenesis.	Water	49-54	transglutaminase 2	Homo sapiens	181-188
15033273-7	2004	Furthermore, in the OCTA test the apoE KO mice were significantly less successful than WT mice at avoiding water containing an odorant and a bad tastant.	Water	107-112	apolipoprotein E	Mus musculus	34-38
15267560-10	2004	In addition, the models that give a good representation of the water structure at ambient conditions (TIP5P, SPCE, and TIP4P) show considerably better agreement with the experimental data than the ones which exhibit less structured O-O correlation functions (SPC and TIP3P).	Water	63-68	proline rich protein gene cluster	Homo sapiens	109-112
15046515-0	2004	The organometallic fac-[(CO)3Mn(H2O)3]+ aquaion: base-hydrolysis and kinetics of H2O-substitution.	Water	32-35	FA complementation group C	Homo sapiens	19-22
15112824-2	2004	Mercury is deposited on the water surface in both gaseous (reactive gaseous mercury, RGM) and particulate (particulate mercury, Hg(p)) forms.	Water	28-33	repulsive guidance molecule BMP co-receptor a	Homo sapiens	85-88
15046515-0	2004	The organometallic fac-[(CO)3Mn(H2O)3]+ aquaion: base-hydrolysis and kinetics of H2O-substitution.	Water	81-84	FA complementation group C	Homo sapiens	19-22
15066808-5	2004	In a 14-month survey, 4 (4.1%) and 7 (7.1%) of 98 tap water samples (100 to 532 liters) contained a detectable amount of noroviruses of genotype 1 and genotype 2, respectively.	Water	54-59	SEC14 like lipid binding 2	Homo sapiens	50-53
14715716-3	2004	In this study we used restraint stress in water to elucidate the mechanism by which PRLR in the rat brain mediate the protective effect of PRL against stress-induced hypocalcemia and ulcerogenesis.	Water	42-47	prolactin	Rattus norvegicus	84-87
15074622-0	2004	DBP levels in chlorinated drinking water: effect of humic substances.	Water	35-40	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
15053653-5	2004	A method was developed to extract 10 PCB congeners from 1-mL water samples (after addition of 40% acetonitrile) with an extraction time of 10 min.	Water	61-66	pyruvate carboxylase	Homo sapiens	37-40
14998726-8	2004	In addition, we found that both the water-soluble Vitamin E derivative, Trolox, and the green tea constituent, (-)-epigallocatechin gallate (EGCG), diminished AAPH-induced COX-2 expression and p38 activation.	Water	36-41	prostaglandin-endoperoxide synthase 2	Homo sapiens	172-177
14998726-8	2004	In addition, we found that both the water-soluble Vitamin E derivative, Trolox, and the green tea constituent, (-)-epigallocatechin gallate (EGCG), diminished AAPH-induced COX-2 expression and p38 activation.	Water	36-41	mitogen-activated protein kinase 1	Homo sapiens	193-196
15261075-0	2004	Surface pressure dependence of phospholipase A2 activity in lipid monolayers is linked to interfacial water activity.	Water	102-107	phospholipase A2 group IB	Homo sapiens	31-47
15261075-5	2004	These results suggested that the mechanism of control of PLA2 activity at the lipid-water interface might involve modulation of the hydration state of the enzyme through control of the thermodynamic activity of water in the interfacial region.	Water	84-89	phospholipase A2 group IB	Homo sapiens	57-61
15261075-5	2004	These results suggested that the mechanism of control of PLA2 activity at the lipid-water interface might involve modulation of the hydration state of the enzyme through control of the thermodynamic activity of water in the interfacial region.	Water	211-216	phospholipase A2 group IB	Homo sapiens	57-61
15024704-2	2004	The aim of the present investigation was to determine if human articular chondrocytes and synoviocytes express aquaporin 1 (AQP1) water channels and to establish if there are any alterations in AQP1 expression in osteoarticular disorders such as osteoarthritis (OA) and rheumatoid arthritis (RA).	Water	130-135	aquaporin 1 (Colton blood group)	Homo sapiens	124-128
15024704-12	2004	These findings suggest a potential role for AQP1 and possibly other members of the AQP gene family in the movement of extracellular matrix and metabolic water across the membranes of chondrocytes and synoviocytes for the purposes of chondrocyte volume regulation and synovial homeostasis.	Water	153-158	aquaporin 1 (Colton blood group)	Homo sapiens	44-48
14727019-0	2004	Validation of C1-esterase inhibitor therapy in severe capillary leak syndrome by monitoring of extravascular lung water.	Water	114-119	complement C1s	Homo sapiens	14-25
15070970-1	2004	Autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) is a defect in free water conservation caused by mutations in the single gene that encodes both vasopressin (VP) and its binding protein, neurophysin II (NP II).	Water	83-88	arginine vasopressin	Homo sapiens	159-170
15089972-6	2004	The circulating peptide hormones angiotensin II and relaxin also have access to peptide specific receptors (AT(1) and LGR7 receptors, respectively) in the subfornical organ and OVLT, and both angiotensin II and relaxin act on the subfornical organ to stimulate water drinking in the rat.	Water	261-266	angiotensinogen	Rattus norvegicus	33-47
15115770-3	2004	Hydrogen peroxide is converted to water and oxygen by catalase.	Water	34-39	catalase	Homo sapiens	54-62
15072572-7	2004	angiotensin II injections, as evaluated by water ingestion.	Water	43-48	angiotensinogen	Rattus norvegicus	0-14
15089972-6	2004	The circulating peptide hormones angiotensin II and relaxin also have access to peptide specific receptors (AT(1) and LGR7 receptors, respectively) in the subfornical organ and OVLT, and both angiotensin II and relaxin act on the subfornical organ to stimulate water drinking in the rat.	Water	261-266	angiotensinogen	Rattus norvegicus	192-206
14718582-9	2004	A flavoprotein oxidase inhibitor (diphenylene iodonium) and a hydroxy radical scavenger (butylated hydroxy anisole) also displayed the effects of DHPs.	Water	62-77	deoxyhypusine synthase	Homo sapiens	146-150
15060871-8	2004	Serum albumin was higher with annual vascular access surveillance, higher BMI among women, higher urea reduction ratio, among patients in whom dialyzers were reprocessed (particularly with bleach), among dialysis units in which water purification was used, and when vascular access blood flow rates were &gt; or =350 mL/min.	Water	228-233	albumin	Homo sapiens	0-13
15109940-0	2004	Influence of arginine vasopressin receptors and angiotensin receptor subtypes on the water intake and arterial blood pressure induced by vasopressin injected into the lateral septal area of the rat.	Water	85-90	arginine vasopressin	Rattus norvegicus	137-148
15016894-4	2004	In the CD4-bound conformation of gp120, the amino acid residues implicated in BMS-806 and #155 resistance line the "phenylalanine 43 cavity" and a water-filled channel that extends from this cavity to the inner domain.	Water	147-152	CD4 molecule	Homo sapiens	7-10
15098812-12	2004	Careful monitoring of water and sodium balance is warranted in all patients treated with vasopressin for septic shock.	Water	22-27	arginine vasopressin	Homo sapiens	89-100
15099911-0	2004	Interaction between supraoptic nucleus and septal area in the control of water, sodium intake and arterial blood pressure induced by injection of angiotensin II.	Water	73-78	angiotensinogen	Homo sapiens	146-160
15306051-2	2004	When thin single crystals of catalase are dried within water alone, low-dose electron diffraction yields no Bragg spots.	Water	55-60	catalase	Homo sapiens	29-37
15044735-4	2004	For example, the four water molecules in the inhibitor-free structures of AST and BT are channeled into similar positions in the S1 site, and the nitrogen atom(s) of the inhibitors are found in two cationic binding sites denoted Position1 and Position2.	Water	22-27	solute carrier family 17 member 5	Homo sapiens	74-77
15109940-3	2004	Both the AT1 and AT2 ligands administered into the LSA elicited a concentration-dependent decrease in the water intake induced by AVP injected into the LSA, but losartan was more effective than CGP42112A.	Water	106-111	arginine vasopressin	Rattus norvegicus	130-133
15109940-11	2004	These results suggest that facilitator effects of AVP on water intake are mediated through the activation of V1 receptors and that the inhibitory effect requires V2 receptors.	Water	57-62	arginine vasopressin	Rattus norvegicus	50-53
15109940-13	2004	Based on the present findings, we suggest that the AVP in the LSA may play a role in the control of water and arterial blood pressure balance.	Water	100-105	arginine vasopressin	Rattus norvegicus	51-54
14722067-9	2004	A molecular dynamics simulation of the DeltaK9 thrombin in full explicit water solvent provided support to the role of the A-chain in affecting conformation and catalytic properties of the B-chain, especially in some insertion loops of the enzyme, such as the 60-loop, as well as in the geometry of the catalytic triad residues.	Water	73-78	coagulation factor II, thrombin	Homo sapiens	47-55
15835150-5	2004	Surface pressure-area isotherm measurements and polarized UV-vis absorption spectroscopic studies indicate that the 2Por-TAZ molecules adopted an edge-on orientation at the air-water interface.	Water	177-182	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	121-124
15835150-6	2004	Polarized UV-vis absorption study also revealed that the 2Por-TAZ molecules formed linear supramolecular networks on pure water and barbituric acid subphase with porphyrin flat planes facing toward the compression direction.	Water	122-127	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	62-65
15801450-0	2004	Lysozyme adsorption studies at the silica/water interface using dual polarization interferometry.	Water	42-47	lysozyme	Homo sapiens	0-8
14988040-1	2004	Our recent results showed that angiotensin II or III (AII, AIII) microinjected into the zona incerta (ZI) significantly increased water intake.	Water	130-135	angiotensinogen	Homo sapiens	31-52
14701836-1	2004	Aquaporin-1 (AQP1) is a membrane channel that allows rapid water movement driven by a transmembrane osmotic gradient.	Water	59-64	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
14701836-1	2004	Aquaporin-1 (AQP1) is a membrane channel that allows rapid water movement driven by a transmembrane osmotic gradient.	Water	59-64	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
14979730-1	2004	The secondary structure of protein kinase C alpha (PKC alpha) has been studied using infrared spectroscopy in the presence of both H(2)O and D(2)O buffers.	Water	131-136	protein kinase C alpha	Homo sapiens	27-49
14979730-1	2004	The secondary structure of protein kinase C alpha (PKC alpha) has been studied using infrared spectroscopy in the presence of both H(2)O and D(2)O buffers.	Water	131-136	protein kinase C alpha	Homo sapiens	51-60
15089713-3	2004	Monte Carlo simulations and calculations show that this can be explained by the confinement of lysozyme molecules to the narrow water cells in the cubic phase.	Water	128-133	lysozyme	Homo sapiens	95-103
15074678-0	2004	X-ray absorption spectroscopic evidence for the formation of Pb(II) inner-sphere adsorption complexes and precipitates at the calcite-water interface.	Water	134-139	submaxillary gland androgen regulated protein 3B	Homo sapiens	61-67
15074678-1	2004	Combined batch sorption and in situ X-ray absorption spectroscopy provide direct assessment of the mechanisms for Pb(II) sorption atthe calcite--water interface under low-temperature conditions.	Water	145-150	submaxillary gland androgen regulated protein 3B	Homo sapiens	114-120
15801450-1	2004	Lysozyme adsorption at the silica/water interface has been studied using a new analytical technique called dual polarization interferometry.	Water	34-39	lysozyme	Homo sapiens	0-8
14985303-6	2004	RESULTS: gammaE-Crystallin, a water-soluble protein that is specifically expressed in lens fibers, was identified as a binding protein to the MIP C-terminal peptide.	Water	30-35	major intrinsic protein of lens fiber	Homo sapiens	142-145
14687662-12	2004	These data show that the insulin-stimulated oxidant signal differentially affects the two major downstream components of the insulin signaling pathway, PI 3"-kinase and MAP kinase, and cross-talk between insulin action, PLCgamma and, to a lesser extent, PKA modulates the net cellular effects of insulin-stimulated cellular H(2)O(2).	Water	324-329	insulin	Homo sapiens	25-32
14687662-12	2004	These data show that the insulin-stimulated oxidant signal differentially affects the two major downstream components of the insulin signaling pathway, PI 3"-kinase and MAP kinase, and cross-talk between insulin action, PLCgamma and, to a lesser extent, PKA modulates the net cellular effects of insulin-stimulated cellular H(2)O(2).	Water	324-329	insulin	Homo sapiens	125-132
14687662-12	2004	These data show that the insulin-stimulated oxidant signal differentially affects the two major downstream components of the insulin signaling pathway, PI 3"-kinase and MAP kinase, and cross-talk between insulin action, PLCgamma and, to a lesser extent, PKA modulates the net cellular effects of insulin-stimulated cellular H(2)O(2).	Water	324-329	insulin	Homo sapiens	125-132
14687662-12	2004	These data show that the insulin-stimulated oxidant signal differentially affects the two major downstream components of the insulin signaling pathway, PI 3"-kinase and MAP kinase, and cross-talk between insulin action, PLCgamma and, to a lesser extent, PKA modulates the net cellular effects of insulin-stimulated cellular H(2)O(2).	Water	324-329	insulin	Homo sapiens	125-132
14988827-3	2004	We investigated the expression, the cellular localization, and the functional role of guanylin, a bioactive intestinal peptide involved in the cystic fibrosis transmembrane conductance regulator (CFTR)-regulated electrolyte/water secretion, in the human gallbladder.	Water	224-229	CF transmembrane conductance regulator	Homo sapiens	143-194
14988827-3	2004	We investigated the expression, the cellular localization, and the functional role of guanylin, a bioactive intestinal peptide involved in the cystic fibrosis transmembrane conductance regulator (CFTR)-regulated electrolyte/water secretion, in the human gallbladder.	Water	224-229	CF transmembrane conductance regulator	Homo sapiens	196-200
14978158-13	2004	Both ang1 and VEGF modulate GEnC barrier properties, consistent with potential in vivo roles; ang1 stabilizing the endothelium and resisting angiogenesis while VEGF induces the high permeability to water, characteristic of the glomerular endothelium.	Water	198-203	vascular endothelial growth factor A	Homo sapiens	14-18
14978158-13	2004	Both ang1 and VEGF modulate GEnC barrier properties, consistent with potential in vivo roles; ang1 stabilizing the endothelium and resisting angiogenesis while VEGF induces the high permeability to water, characteristic of the glomerular endothelium.	Water	198-203	vascular endothelial growth factor A	Homo sapiens	160-164
14592814-0	2004	Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology.	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	18-23
14592814-2	2004	Aquaporin-1 (AQP-1) has been found to be important in osmotic water movement across cell membranes of epithelial and endothelial barriers.	Water	62-67	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
14592814-2	2004	Aquaporin-1 (AQP-1) has been found to be important in osmotic water movement across cell membranes of epithelial and endothelial barriers.	Water	62-67	aquaporin 1 (Colton blood group)	Homo sapiens	13-18
15074798-8	2004	Evaluations suggest that shallow ground water discharge will cause NO3- -N and Cl- in the Oldman River to increase by factors of at least 4.3 and 1.3, respectively, with more significant effects in smaller streams and under low-flow conditions.	Water	40-45	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
14735577-2	2004	The carbonium ion t-Bu(+) that is normally sandwiched between the water clusters was found to be absent, such that a Cbond;O covalent bond was formed in the intermediate (Int1) after heterolysis.	Water	66-71	Wnt family member 1	Homo sapiens	171-175
14991940-15	2004	Incubation of rat hepatic nuclei with Fe(3+)/H(2)O(2) (1 m mol/L vs 5 micromol/L) resulted in a decrease in nuclear NTPase activities (P&lt;0.01).	Water	45-50	inosine triphosphatase	Rattus norvegicus	116-122
14668972-9	2004	When the method was applied to spiked chlorinated tap water samples, it was found that peptides containing methionine, tryptophan and cystine were oxidized.	Water	54-59	USO1 vesicle transport factor	Homo sapiens	50-53
15268486-0	2004	Direct observation of an isopolyhalomethane O-H insertion reaction with water: picosecond time-resolved resonance Raman (ps-TR3) study of the isobromoform reaction with water to produce a CHBr2OH product.	Water	169-174	thioredoxin reductase 2	Homo sapiens	124-127
15268486-1	2004	Picosecond time-resolved resonance Raman (ps-TR3) spectroscopy was used to obtain the first definitive spectroscopic observation of an isopolyhalomethane O-H insertion reaction with water.	Water	182-187	thioredoxin reductase 2	Homo sapiens	45-48
15268486-2	2004	The ps-TR3 spectra show that isobromoform is produced within several picoseconds after photolysis of CHBr3 and then reacts on the hundreds of picosecond time scale with water to produce a CHBr2OH reaction product.	Water	169-174	thioredoxin reductase 2	Homo sapiens	7-10
14746895-6	2004	administration of ANG II (10 pmol) resulted in increases in MABP and water intake that were similar in alpha(1D)(-/-) mice and alpha(1D)(+/+) mice.	Water	69-74	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	18-24
14644747-2	2004	One of the key factors in concentrating the urine is the renal collecting duct osmotic water permeability (Pf) response to antidiuretic hormone (ADH).	Water	87-92	arginine vasopressin	Homo sapiens	123-143
14644747-2	2004	One of the key factors in concentrating the urine is the renal collecting duct osmotic water permeability (Pf) response to antidiuretic hormone (ADH).	Water	87-92	arginine vasopressin	Homo sapiens	145-148
14969655-1	2004	The renin-angiotensin-aldosterone system regulates renal vasomotor activity, maintains optimal salt and water homeostasis, and controls tissue growth in the kidney.	Water	104-109	renin	Homo sapiens	4-9
14966924-5	2004	METHODS: Rats drank a nicotine solution while control rats drank tap water for 20 days.	Water	69-74	nuclear RNA export factor 1	Rattus norvegicus	65-68
14532164-1	2004	Vasopressin regulates water and solute transport in the renal collecting duct.	Water	22-27	arginine vasopressin	Rattus norvegicus	0-11
14968862-7	2004	Small droplet diameter, decreased temperature, and the presence of dissolved surface-active material in water enhanced the uptake of naphthalene into fog droplets.	Water	104-109	zinc finger protein, FOG family member 1	Homo sapiens	150-153
14663547-11	2004	The same is true for comparison between water and water-acetic acid for folded cyt c and Lyz.	Water	40-45	cytochrome c, somatic	Homo sapiens	79-84
14663547-11	2004	The same is true for comparison between water and water-acetic acid for folded cyt c and Lyz.	Water	40-45	lysozyme	Homo sapiens	89-92
14663547-11	2004	The same is true for comparison between water and water-acetic acid for folded cyt c and Lyz.	Water	50-55	cytochrome c, somatic	Homo sapiens	79-84
14663547-11	2004	The same is true for comparison between water and water-acetic acid for folded cyt c and Lyz.	Water	50-55	lysozyme	Homo sapiens	89-92
14723878-7	2004	Salt water acclimated Atlantic salmon smolts (Salmo salar) bathed for 2 h in fresh water showed significantly lower IGF-I concentrations than control smolts two days after the bath (53.1 compared to 32.1 ng/ml), with levels of IGF-I also lower in smolts exhibiting stunted growth (stunts).	Water	5-10	insulin like growth factor 1	Homo sapiens	116-121
14723878-7	2004	Salt water acclimated Atlantic salmon smolts (Salmo salar) bathed for 2 h in fresh water showed significantly lower IGF-I concentrations than control smolts two days after the bath (53.1 compared to 32.1 ng/ml), with levels of IGF-I also lower in smolts exhibiting stunted growth (stunts).	Water	5-10	insulin like growth factor 1	Homo sapiens	227-232
14731277-4	2004	TraR is thought to bind OOHL via four hydrogen bonds, three of them direct and one water mediated, and by numerous hydrophobic interactions.	Water	83-88	transcriptional regulator TraR	Agrobacterium tumefaciens	0-4
14969849-1	2004	BACKGROUND: Salvianolic acid B (SA-B), one of water soluble compounds derived from Radix salviae miltiorrhizae, had good action against liver fibrosis of patients with chronic hepatitis.	Water	46-51	SH3 domain binding protein 5	Homo sapiens	32-36
18494919-2	2004	However, correlations between itch and objective measures of barrier function and skin dryness such as skin hydration and transepidermal water loss have been rarely found.	Water	137-142	itchy, E3 ubiquitin protein ligase	Mus musculus	30-34
14706834-2	2004	In order to characterize the function of these immunoanalogues we have expressed the full-length recombinant (AtPNP-A[1-126]) and demonstrate that this molecule induces osmoticum-dependent H(2)O uptake into protoplasts at nanomolar concentrations and thus affects cell volume.	Water	189-194	plant natriuretic peptide A	Arabidopsis thaliana	110-117
15095624-2	2004	Calcium from mineral water is readily absorbed, inhibits PTH secretion and bone resorption on the short as well as on the long term.	Water	21-26	parathyroid hormone	Homo sapiens	57-60
15449549-9	2004	The free water clearance decreased significantly during octreotide administration (3.12 ml/min+/-1.04 SE vs 0.88+/-0.39, p&lt;.03).	Water	9-14	CD59 molecule (CD59 blood group)	Homo sapiens	91-98
15132871-3	2004	A water soluble substance (AP3) was isolated from a Chinese herb Herba patriniae, by hot water extraction, ethol precipitation and gel permeation column chromatography.	Water	2-7	adaptor-related protein complex 3, beta 1 subunit	Mus musculus	27-30
14744759-8	2004	Quenching H(2)O(2) by catalase delays the occurrence of both normal and premature cRel-induced senescence.	Water	10-15	catalase	Homo sapiens	22-30
14745661-2	2004	Approximately one third of these patients have elevated blood pressure due to increased sodium and water retention by the kidney resulting in suppressed plasma renin and aldosterone concentrations with high urinary potassium excretion and low plasma potassium levels.	Water	99-104	renin	Homo sapiens	160-165
14630996-1	2004	In hyperprostaglandin E syndrome (HPGES) and classic Bartter syndrome (cBS), tubular salt and water losses stimulate renin secretion, which is dependent on enhanced cyclooxygenase-2 (COX-2) enzymatic activity.	Water	94-99	renin	Homo sapiens	117-122
15143508-6	2004	After the water load and injection of 0.005 nmole/100 g body mass of arginine-vasopressin for 2 hr of the study, diuresis in both groups of animals decreased to an equal extent, but in fasting animals this was due mostly to an increase of the osmotic free water.	Water	256-261	arginine vasopressin	Rattus norvegicus	78-89
14753679-6	2004	The aqueous solubility of CL-20 was poor (3.6 mg l(-1) at 25 degrees C) and increased with temperature to reach 18.5 mg l(-1) at 60 degrees C. The octanol-water partition coefficient of CL-20 (log KOW = 1.92) was higher than that of RDX (log KOW = 0.90) and HMX (log KOW = 0.16), indicating its higher affinity to organic matter.	Water	155-160	epithelial membrane protein 1	Homo sapiens	26-31
14753679-7	2004	Finally, CL-20 was found to decompose in non-acidified water upon contact with glass containers to give NO2- (2 equiv.	Water	55-60	epithelial membrane protein 1	Homo sapiens	9-14
14697237-1	2004	Angiotensin II acting centrally contributes to the regulation of blood pressure and water intake and stimulates the release of catecholamines from the adrenal medulla.	Water	84-89	angiotensinogen	Rattus norvegicus	0-14
14654409-3	2004	SEC-2 can form a stable monolayer at the air-water interface.	Water	45-50	fucosyltransferase 2	Homo sapiens	0-5
12954599-0	2004	Effects of high altitude and water deprivation on arginine vasopressin release in men.	Water	29-34	arginine vasopressin	Homo sapiens	59-70
15568732-6	2004	In this study Balb/c female mice were fed (1) standard diet, (2) dNT-supplemented diet, and (3) dNT-supplemented water for 4 weeks.	Water	113-118	doughnut on 2	Drosophila melanogaster	96-99
15568732-10	2004	The highest growth of intestinal villi was observed in group administered dNT-supplemented water.	Water	91-96	doughnut on 2	Drosophila melanogaster	74-77
15673190-7	2004	Liver fibrosis induced by CCl4 markedly increased the weight of the spleen, hepatic water and hydroxyproline contents in rats, while GTE decreased the rat"s spleen weights, hepatic water and hydroxyproline contents.	Water	84-89	C-C motif chemokine ligand 4	Rattus norvegicus	26-30
14753259-1	2004	Water samples from radiation and upslope types of fog were collected at Takanosu Basin and Hachimantai mountain range of Akita Prefecture in northern Japan, respectively.	Water	0-5	zinc finger protein, FOG family member 1	Homo sapiens	50-53
14753259-4	2004	The transport and uptake mechanism of pollutants in the radiation fog water were explained based on their accumulation in the basin due to anticyclonic subsidence and by the long-lasting fog behavior.	Water	70-75	zinc finger protein, FOG family member 1	Homo sapiens	66-69
14753259-4	2004	The transport and uptake mechanism of pollutants in the radiation fog water were explained based on their accumulation in the basin due to anticyclonic subsidence and by the long-lasting fog behavior.	Water	70-75	zinc finger protein, FOG family member 1	Homo sapiens	187-190
15029719-3	2004	The adsorption of A beta to the water-air interface and to the surface of the dipalmitoylphosphatidylethanolamine monolayer at a surface pressure pi close to zero leads to an increase in pressure up to 17 mN/m.	Water	32-37	amyloid beta precursor protein	Homo sapiens	18-24
14969348-2	2004	The n-butanol fraction from the water extract of the stems, when pretreated orally at 200 mg/kg/day for 7 consecutive days in rats, was demonstrated to exhibit significant increases in antioxidant enzyme activities such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase by 30.31, 19.82 and 155%, respectively.	Water	32-37	catalase	Rattus norvegicus	263-271
14759764-4	2004	AQP-1 and Galphai3 have been implicated in GTP-induced gating of water in zymogen granules (ZG), the secretory vesicles in exocrine pancreas.	Water	65-70	aquaporin 1 (Colton blood group)	Homo sapiens	0-5
15029719-2	2004	After treatment with hexafluoroisopropanol, commercial A beta is readily soluble in water and buffers at pH 7.4 and has an irregular secondary structure.	Water	84-89	amyloid beta precursor protein	Homo sapiens	55-61
14695248-0	2004	Theory and simulation of water permeation in aquaporin-1.	Water	25-30	aquaporin 1 (Colton blood group)	Homo sapiens	45-56
14695256-3	2004	We have investigated this phenomenon by comparing a Na+/glucose (hSGLT1) induced water flux to water fluxes triggered either by a cationic inward current (using ROMK2 K+ channels) or by a glucose influx (using GLUT2, a passive glucose transporter).	Water	81-86	solute carrier family 5 member 1	Homo sapiens	65-71
15366973-14	2004	Additionally, glitazones may potentiate the renal effects of insulin on sodium and water retention.	Water	83-88	insulin	Homo sapiens	61-68
15090867-9	2004	When inappropriately stimulated, high intrarenal angiotensin II levels contribute to excessive salt and water retention, the development of hypertension, and long-term proliferative effects leading to renal injury.	Water	104-109	angiotensinogen	Homo sapiens	49-63
16305368-8	2004	MDR1 (P-glycoprotein) and ABCG2 preferentially extrude large hydrophobic, positively charged molecules, while the members of the MRP family can extrude both hydrophobic uncharged molecules and water-soluble anionic compounds.	Water	193-198	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
16305368-8	2004	MDR1 (P-glycoprotein) and ABCG2 preferentially extrude large hydrophobic, positively charged molecules, while the members of the MRP family can extrude both hydrophobic uncharged molecules and water-soluble anionic compounds.	Water	193-198	ATP binding cassette subfamily B member 1	Homo sapiens	6-20
16305368-8	2004	MDR1 (P-glycoprotein) and ABCG2 preferentially extrude large hydrophobic, positively charged molecules, while the members of the MRP family can extrude both hydrophobic uncharged molecules and water-soluble anionic compounds.	Water	193-198	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	26-31
15022889-1	2004	Arginine-vasopressin (VP), also known as the antidiuretic hormone, is essential for water homeostasis.	Water	84-89	arginine vasopressin	Homo sapiens	0-20
16276829-4	2004	The recent research results indicated much more extensive effects of endogenous vasopressin action on the circulation than appeared from the water-electrolyte balance regulation only.	Water	141-146	arginine vasopressin	Homo sapiens	80-91
15022889-1	2004	Arginine-vasopressin (VP), also known as the antidiuretic hormone, is essential for water homeostasis.	Water	84-89	arginine vasopressin	Homo sapiens	22-24
15022889-1	2004	Arginine-vasopressin (VP), also known as the antidiuretic hormone, is essential for water homeostasis.	Water	84-89	arginine vasopressin	Homo sapiens	45-65
15244341-4	2004	The OCN pellet slowly releases calcium and nitrate, together with ocher, into the sediment water interface, where all three components play an important role in reducing phosphate release from sediments.	Water	91-96	bone gamma-carboxyglutamate protein	Homo sapiens	4-7
14975357-1	2004	It had been shown previously that MRL+/+ mice exposed to occupationally relevant doses of the environmental contaminant trichloroethylene in their drinking water developed lupus-like symptoms and autoimmune hepatitis in association with activation of Interferon-gamma (IFN-gamma)-producing CD4+ T cells.	Water	156-161	interferon gamma	Mus musculus	251-267
16649586-5	2004	Leaching of As(III) and As(v) from exhausted CalSiCo is also carried out in rainwater and in tap water.	Water	80-85	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-29
15244341-13	2004	The proposed method has two major advantages compared to previous methods: (1) effective reduction of phosphate release due to the synergism of calcium, nitrate, and ocher; and (2) ease of use in natural systems, in such manner that the OCN pellets can be simply scattered over the water surface.	Water	282-287	bone gamma-carboxyglutamate protein	Homo sapiens	237-240
15272728-1	2004	Al13 or Alb is usually regarded as the most efficient species of polyaluminum chloride (PAC), the performance flocculant for water treatment.	Water	125-130	albumin	Homo sapiens	8-11
15187287-2	2004	One of these processes consists of the detoxification of reactive oxygen species by the ascorbate peroxidase (APX) family of enzymes, which convert H2O2 into H2O.	Water	148-151	peroxidase	Arabidopsis thaliana	98-108
15561405-10	2004	The hormonal regulation of water and ionic homeostasis is achieved by the opposing effects of vasopressin and atrial natriuretic peptide on astroglial water and chloride uptake.	Water	27-32	arginine vasopressin	Homo sapiens	94-105
15450351-9	2004	While the presence of AQP9 in glia limitans and in endothelial cells of the pial vessels could be related to water transport through the blood-brain barrier, its expression in neuronal cells, not directly involved in the osmoregulation, suggests that brain AQP9 could also be used as a metabolite channel since lactate and glycerol can be energy substrates for neurons.	Water	109-114	aquaporin 9	Rattus norvegicus	22-26
15561410-5	2004	Mercury inhibits the water permeability of AQP1 and AQP9, but not AQP4.	Water	21-26	aquaporin 1 (Colton blood group)	Homo sapiens	43-47
15561410-5	2004	Mercury inhibits the water permeability of AQP1 and AQP9, but not AQP4.	Water	21-26	aquaporin 9	Homo sapiens	52-56
15450351-1	2004	Aquaporin 9 (AQP9) is a recently cloned water channel that is permeable to monocarboxylate, glycerol and urea.	Water	40-45	aquaporin 9	Rattus norvegicus	0-11
15450351-1	2004	Aquaporin 9 (AQP9) is a recently cloned water channel that is permeable to monocarboxylate, glycerol and urea.	Water	40-45	aquaporin 9	Rattus norvegicus	13-17
15561411-8	2004	Aquaporin 1 mediates water transport at the apical membrane, but the route across the basolateral membrane is unknown.	Water	21-26	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
15561405-10	2004	The hormonal regulation of water and ionic homeostasis is achieved by the opposing effects of vasopressin and atrial natriuretic peptide on astroglial water and chloride uptake.	Water	151-156	arginine vasopressin	Homo sapiens	94-105
15561412-1	2004	Aquaporin 9 (AQP9) is a member of the aquaporin channel family involved in water flux through plasma membranes and exhibits the distinct feature of being also permeable to monocarboxylates, such as lactate, and various solutes, including glycerol, carbamides, purines, pyrimidines, and urea.	Water	75-80	aquaporin 9	Homo sapiens	0-11
15561408-1	2004	Each day, approximately 0.5-0.9 l of water diffuses through (primarily) aquaporin-1 (AQP1) channels in the human choroid plexus, into the cerebrospinal fluid of the brain ventricles and spinal cord central canal, through the ependymal cell lining, and into the parenchyma of the CNS.	Water	37-42	aquaporin 1 (Colton blood group)	Homo sapiens	72-83
15561412-1	2004	Aquaporin 9 (AQP9) is a member of the aquaporin channel family involved in water flux through plasma membranes and exhibits the distinct feature of being also permeable to monocarboxylates, such as lactate, and various solutes, including glycerol, carbamides, purines, pyrimidines, and urea.	Water	75-80	aquaporin 9	Homo sapiens	13-17
15561408-1	2004	Each day, approximately 0.5-0.9 l of water diffuses through (primarily) aquaporin-1 (AQP1) channels in the human choroid plexus, into the cerebrospinal fluid of the brain ventricles and spinal cord central canal, through the ependymal cell lining, and into the parenchyma of the CNS.	Water	37-42	aquaporin 1 (Colton blood group)	Homo sapiens	85-89
15561414-14	2004	These results demonstrate that dystrophin is necessary for polarized distribution of AQP4 protein in brain where facilitated movements of water occur across the BBB and cerebrospinal fluid-brain interface.	Water	138-143	dystrophin, muscular dystrophy	Mus musculus	31-41
14670476-2	2004	The ligand and its metal complexes (Co(II)-PAN and Ni(II)-PAN) were made water-soluble by the neutral surfactant Triton X-100, and therefore, no extraction with organic solvents was required.	Water	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
14974719-12	2004	Within a relatively small range between a lower activation threshold and an upper threshold that leads to cell death, the hsp70 response followed an Arrhenius relationship when constant-temperature water bath and laser experiments were carried out.	Water	198-203	heat shock protein 1B	Mus musculus	122-127
14593480-8	2004	In addition, dpe2 mutants accumulated starch and a water-soluble, ethanol/KCl-insoluble maltodextrin in their chloroplasts.	Water	51-56	disproportionating enzyme 2	Arabidopsis thaliana	13-17
15984652-7	2004	Half of the 2003 Nobel Prize in Chemistry was awarded to Peter Agre (Johns Hopkins University, Baltimore, USA) "for the discovery of water channels", actually the first water channel protein from the human red blood cell (RBC) membrane, known today as aquaporin 1 (AQP1).	Water	133-138	aquaporin 1 (Colton blood group)	Homo sapiens	252-263
15984652-7	2004	Half of the 2003 Nobel Prize in Chemistry was awarded to Peter Agre (Johns Hopkins University, Baltimore, USA) "for the discovery of water channels", actually the first water channel protein from the human red blood cell (RBC) membrane, known today as aquaporin 1 (AQP1).	Water	133-138	aquaporin 1 (Colton blood group)	Homo sapiens	265-269
15984652-7	2004	Half of the 2003 Nobel Prize in Chemistry was awarded to Peter Agre (Johns Hopkins University, Baltimore, USA) "for the discovery of water channels", actually the first water channel protein from the human red blood cell (RBC) membrane, known today as aquaporin 1 (AQP1).	Water	169-174	aquaporin 1 (Colton blood group)	Homo sapiens	252-263
14662748-1	2003	Vasopressin regulates body water conservation by redistributing aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical surface of renal collecting ducts, resulting in water reabsorption from urine.	Water	27-32	aquaporin 2 S homeolog	Xenopus laevis	64-75
15237640-1	2004	Barcelona"s drinking water has two distinct origins: the Ter and Llobregat rivers supply the city in a ratio of 35/65.	Water	21-26	trans-2,3-enoyl-CoA reductase	Homo sapiens	57-60
15237640-3	2004	Treated water from the Llobregat sometimes has organoleptic problems, whereas the quality of treated water from the Ter is much better.	Water	101-106	trans-2,3-enoyl-CoA reductase	Homo sapiens	116-119
15237640-5	2004	The optimum blend of Ter and Llobregat water is the blend that contains the highest percentage of Llobregat water without any appreciable loss of the characteristics of Ter water.	Water	108-113	trans-2,3-enoyl-CoA reductase	Homo sapiens	21-24
15237640-5	2004	The optimum blend of Ter and Llobregat water is the blend that contains the highest percentage of Llobregat water without any appreciable loss of the characteristics of Ter water.	Water	108-113	trans-2,3-enoyl-CoA reductase	Homo sapiens	21-24
15237643-0	2004	Public thresholds for chlorinous flavors in U.S. tap water.	Water	53-58	SEC14 like lipid binding 2	Homo sapiens	49-52
15237643-6	2004	The measured sensitivity limit of average American populations to free chlorine (159 persons tested) and chloramine (93 persons tested) in tap water were 0.8 and 3.7 mg/L Cl2, respectively.	Water	143-148	SEC14 like lipid binding 2	Homo sapiens	139-142
14651933-1	2003	STK, the Src tyrosine kinase homologous of the fresh water polyp hydra, is a key component of the signal transduction system for cell differentiation in this organism.	Water	53-58	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	9-12
14637135-3	2003	Here, it is shown that ferrous MPO heterolytically cleaves hydrogen peroxide forming water and oxyferryl MPO (compound II).	Water	85-90	myeloperoxidase	Homo sapiens	31-34
14730506-3	2004	In the kidney, the CaSR regulates renal calcium excretion and influences the transepithelial movement of water and other electrolytes.	Water	105-110	calcium sensing receptor	Homo sapiens	19-23
14630097-0	2004	Unsteady diffusional mass transfer at the sediment/water interface: Theory and significance for SOD measurement.	Water	51-56	superoxide dismutase 1	Homo sapiens	96-99
14630097-1	2004	Dissolved oxygen uptake at a sediment/water interface (SOD) is controlled by mass transport and/or biochemical reactions in two adjacent boundary layers: the diffusive boundary layer delta(D) in the water and the penetration depth delta in the sediment.	Water	38-43	superoxide dismutase 1	Homo sapiens	55-58
14630097-1	2004	Dissolved oxygen uptake at a sediment/water interface (SOD) is controlled by mass transport and/or biochemical reactions in two adjacent boundary layers: the diffusive boundary layer delta(D) in the water and the penetration depth delta in the sediment.	Water	199-204	superoxide dismutase 1	Homo sapiens	55-58
14630097-4	2004	A model was developed for the unsteady response of SOD and DO profiles near the sediment/water interface.	Water	89-94	superoxide dismutase 1	Homo sapiens	51-54
14630097-17	2004	If flow conditions in the chamber and at the natural sediment/water interface are much different, measured SOD values have to be adjusted.	Water	62-67	superoxide dismutase 1	Homo sapiens	107-110
14630116-4	2004	Tap water, spiked with 15,000ngEE2/L was filtered through the reactors with a hydraulic retention time of approximately 1h.	Water	4-9	SEC14 like lipid binding 2	Homo sapiens	0-3
14989826-7	2004	(4) The concentration of PGE(2) released by HPEC treated with 0.10, 0.25 and 0.50 mmol/L of H(2)O(2) in the presence of IL-1beta [(27.01 +/- 5.16) x 10(-6) g/L, (32.79 +/- 3.01) x 10(-6) g/L, (41.13 +/- 3.41) x 10(-6) g/L, respectively] was significantly higher than that in the control group (10.49 +/- 0.36) x 10(-6) g/L (P &lt; 0.05, respectively).	Water	92-98	interleukin 1 beta	Homo sapiens	120-128
14662748-1	2003	Vasopressin regulates body water conservation by redistributing aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical surface of renal collecting ducts, resulting in water reabsorption from urine.	Water	27-32	aquaporin 2 S homeolog	Xenopus laevis	77-81
14662748-1	2003	Vasopressin regulates body water conservation by redistributing aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical surface of renal collecting ducts, resulting in water reabsorption from urine.	Water	83-88	aquaporin 2 S homeolog	Xenopus laevis	64-75
14630029-8	2003	This fact suggests unusual stabilization of the high-spin state of CYP3A4, which is assumed to reflect decreased water accessibility of the heme moiety due to specific interactions of the hemoprotein with the protein partners (b(5) and CPR) and/or membrane lipids.	Water	113-118	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-73
14662748-1	2003	Vasopressin regulates body water conservation by redistributing aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical surface of renal collecting ducts, resulting in water reabsorption from urine.	Water	83-88	aquaporin 2 S homeolog	Xenopus laevis	77-81
14662748-1	2003	Vasopressin regulates body water conservation by redistributing aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical surface of renal collecting ducts, resulting in water reabsorption from urine.	Water	83-88	aquaporin 2 S homeolog	Xenopus laevis	64-75
14662748-1	2003	Vasopressin regulates body water conservation by redistributing aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical surface of renal collecting ducts, resulting in water reabsorption from urine.	Water	83-88	aquaporin 2 S homeolog	Xenopus laevis	77-81
14662748-4	2003	This AQP2 mutant is a functional water channel when expressed in Xenopus oocytes.	Water	33-38	aquaporin 2 S homeolog	Xenopus laevis	5-9
14500765-5	2003	Northern hybridization and immunoblotting studies indicated that the mRNA expression and protein abundance of the collecting duct (CD) water channel AQP2 decreased by 52 % (P &lt; 0.0003) and 73 % (P &lt; 0.003) in the cortex, and by 53 % and 54 % (P &lt; 0.002) in the inner medulla (IM) of Nhe3-/- vs. Nhe3+/+ mice.	Water	135-140	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	292-296
14645082-5	2003	DeltaS degrees cryst&gt;0 indicates release of solvent, mostly water, molecules structured around the hydrophobic patches on the insulin molecules" surface in the solution.	Water	63-68	insulin	Homo sapiens	129-136
14645089-4	2003	These data show that in water NKA prefers to be in an extended chain conformation whereas a helical conformation is induced in the central core and the C-terminal region (D4-M10) of the peptide in the presence of perdeuterated dodecylphosphocholine (DPC) micelles, a membrane model system.	Water	24-29	tachykinin precursor 1	Homo sapiens	30-33
12962703-3	2003	HA sensitized both p53 wild type and mutated glioma cells to 0.25 mM H(2)O(2).	Water	69-74	tumor protein p53	Homo sapiens	19-22
14675200-1	2003	Aquaporin 3 is a channel that transports both water and glycerol.	Water	46-51	aquaporin 3	Mus musculus	0-11
14636070-4	2003	From hydrogen-deuterium exchange, the secondary structure of the water-accessible part of 5-HT(3)R was determined as 14% alpha-helix, 16% beta-strand, 26% beta-turn, and 14% nonregular structures.	Water	65-70	5-hydroxytryptamine receptor 3A	Homo sapiens	90-98
14636070-5	2003	Interestingly, we found that both the overall and the water-accessible nAChR secondary structures were nearly identical to those of 5-HT(3)R, in agreement with predicted structures of this class of receptors.	Water	54-59	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	71-76
12965888-2	2003	We determined the effect of NO on basal and vasopressin (AVP)-stimulated urea (Purea) and water (Pf) permeabilities in isolated, perfused rat IMCD.	Water	90-95	arginine vasopressin	Rattus norvegicus	44-55
14740822-1	2003	The role of the phosphoserine residues on the dynamical and structural properties of beta-casein was studied by molecular dynamics of the protein in water/lipid interfacial regions.	Water	149-154	casein beta	Bos taurus	85-96
14500765-5	2003	Northern hybridization and immunoblotting studies indicated that the mRNA expression and protein abundance of the collecting duct (CD) water channel AQP2 decreased by 52 % (P &lt; 0.0003) and 73 % (P &lt; 0.003) in the cortex, and by 53 % and 54 % (P &lt; 0.002) in the inner medulla (IM) of Nhe3-/- vs. Nhe3+/+ mice.	Water	135-140	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	304-308
14726616-9	2003	These results suggest that modulatory effect of galanin on vasopressin and oxytocin release depends on the actual state of water metabolism.	Water	123-128	galanin and GMAP prepropeptide	Rattus norvegicus	48-55
14632915-7	2003	Finally, by using finely milled diet, a wire mesh floor and tap water, instead of conventional breeding methods of regular diet, bedding and acidic water, it was possible to breed rats with minimal signs of periodontal disease.	Water	64-69	nuclear RNA export factor 1	Rattus norvegicus	60-63
14726616-9	2003	These results suggest that modulatory effect of galanin on vasopressin and oxytocin release depends on the actual state of water metabolism.	Water	123-128	arginine vasopressin	Rattus norvegicus	59-70
14726616-10	2003	Gal acts as an inhibitory neuromodulator of AVP and OT secretion under conditions of the dehydration but stimulates this process in the state of equilibrated water metabolism.	Water	158-163	galanin and GMAP prepropeptide	Rattus norvegicus	0-3
14664791-6	2003	In addition to phenotypic correction, secretion of transgene-derived AVP was enhanced after 24 h water deprivation or hypertonic saline injection, and water diuresis was demonstrated after acute water loading.	Water	97-102	arginine vasopressin	Rattus norvegicus	69-72
15075460-8	2003	In this model, rats are given free access to different of alcohol solutions (5% and 20% v/v) and tap water.	Water	101-106	nuclear RNA export factor 1	Rattus norvegicus	88-100
14688443-0	2003	Regulation of corticosterone production by vasopressin during water restriction and after drinking in rats.	Water	62-67	arginine vasopressin	Rattus norvegicus	43-54
14688443-3	2003	A strong correlation between changes in plasma VP and corticosterone, but not between plasma ACTH and corticosterone, was observed after drinking induced by 6 days of water restriction.	Water	167-172	arginine vasopressin	Rattus norvegicus	47-49
17986548-4	2003	Aquaporin-1 (AQP1) is constitutively expressed in the endothelial cells of the capillaries and venules that provide the ultrasmall pores predicted by the three-pore model of water movement during peritoneal dialysis.	Water	174-179	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
14688443-5	2003	Administration of an immunoneutralizing antibody directed against VP resulted in a rapid decrease in plasma corticosterone, but not ACTH, in water-restricted rats, but not in rats receiving water ad libitum.	Water	141-146	arginine vasopressin	Rattus norvegicus	66-68
17986548-4	2003	Aquaporin-1 (AQP1) is constitutively expressed in the endothelial cells of the capillaries and venules that provide the ultrasmall pores predicted by the three-pore model of water movement during peritoneal dialysis.	Water	174-179	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
14630322-2	2003	The atomic structure of mammalian AQP1 illustrates how this family of proteins is freely permeated by water but not protons (hydronium ions, H3O+).	Water	102-107	aquaporin 1 (Colton blood group)	Homo sapiens	34-38
14629145-7	2003	Nitrotetrahydrobenzo[c]chromenones 13-16, 24, and 25, originating from the normal electron-demand Diels-Alder reactions, were converted into dihydrodibenzo[b,d]furans 27-31 in water, via one-pot Nef-cyclodehydration reactions.	Water	176-181	S100 calcium binding protein B	Homo sapiens	195-198
14621991-8	2003	Within the structure of the nAChR transmembrane domain, deltaTyr-228 projects into an extracellular, water accessible pocket formed by amino acids from the deltaM1-deltaM3 alpha-helices.	Water	101-106	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	28-33
14670733-1	2003	Extraction of dry bacteria of Acinetobacter baumannii strain 24 by phenol-water yielded a lipopolysaccharide (LPS) that was studied by serological methods and fatty acid analysis.	Water	74-79	toll-like receptor 4	Mus musculus	110-113
12930837-3	2003	In the present study, we hypothesized that TGF-beta1 would also decrease vectorial ion and water transport across the distal lung epithelium.	Water	91-96	transforming growth factor, beta 1	Rattus norvegicus	43-52
14595023-2	2003	Toward this goal, we have prepared a series of cyclic peptides that bind to water-soluble metalloporphyrins (FeIII and CoIII).	Water	76-81	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	119-124
14580190-1	2003	The DNA repair enzyme uracil DNA glycosylase has been crystallized with a cationic 1-aza-2"-deoxyribose-containing DNA that mimics the ultimate transition state of the reaction in which the water nucleophile attacks the anomeric center of the oxacarbenium ion-uracil anion reaction intermediate.	Water	190-195	uracil DNA glycosylase	Homo sapiens	22-44
14577772-5	2003	Its eight cyanide groups are coordinated to Co(II) ions which have two coordinated water molecules in trans position.	Water	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
14582958-8	2003	The limit of detection was 17 mug/L NAG in water for the direct competitive enzyme immunoassay.	Water	43-48	N-acetyl-alpha-glucosaminidase	Homo sapiens	36-39
12842853-5	2003	In addition, we assessed the capacity of an mTNF-alpha-derived peptide (mLtip), which activates sodium transport by a receptor-independent mechanism, to reduce lung water content in an isolated, ventilated, autologous blood-perfused rat lung model.	Water	165-170	tumor necrosis factor	Mus musculus	44-54
12881219-12	2003	The addition of 17-octadecynoic acid, a cytochrome P-450 monooxygenase inhibitor, to those inhibitors significantly attenuated the ACh-induced decreases in fluorescence intensity, whereas catalase, an enzyme that dismutates H2O2 to form water and oxygen, did not.	Water	237-242	catalase	Canis lupus familiaris	188-196
14530070-10	2003	A reduction in biomaterial water content induced an increase in complement C3 and fibronectin binding and in cell adhesion to materials, whilst differences in co-monomer formulation had little impact.	Water	27-32	fibronectin 1	Homo sapiens	82-93
12904958-11	2003	The column packed with DHP-anchored cellulose can be reused at least 20 times for enrichment of metal ions in water sample.	Water	110-115	dihydropyrimidinase	Homo sapiens	23-26
12922150-3	2003	Following subcutaneous implantation of the gelatin hydrogels incorporating 125I-labeled BMP-2 into the back of mice, the in vivo retention period of BMP-2 prolonged with a decrease in the water content of hydrogels used, although every time period was much longer than that of BMP-2 solution injection.	Water	188-193	bone morphogenetic protein 2	Mus musculus	88-93
12783226-2	2003	The aim of this study was to evaluate the short-term effect of vasopressin on basolateral cell surface water permeability in the outer medullary collecting duct (OMCD).	Water	103-108	arginine vasopressin	Homo sapiens	63-74
14693261-7	2003	ethanol in 0.1% saccharin or, in the Water group, drinking of tap water in 0.1% saccharin.	Water	66-71	nuclear RNA export factor 1	Rattus norvegicus	62-65
14512384-6	2003	These results suggest some correlation between the activities of beta-mannosidase and endo-beta-mannanase, particularly in the micropylar endosperm, in populations of tomato seeds imbibed in water, abscisic acid and gibberellin.	Water	191-196	LOW QUALITY PROTEIN: mannan endo-1,4-beta-mannosidase 3	Solanum lycopersicum	86-105
14578404-0	2003	Water permeability of C-terminally truncated aquaporin 0 (AQP0 1-243) observed in the aging human lens.	Water	0-5	major intrinsic protein of lens fiber	Homo sapiens	45-56
14578404-0	2003	Water permeability of C-terminally truncated aquaporin 0 (AQP0 1-243) observed in the aging human lens.	Water	0-5	major intrinsic protein of lens fiber	Homo sapiens	58-62
14559970-7	2003	We find that the activation energy for the rupture of the hydrogen bond in a beta-sheet under isolated conditions is 4.76 kcal/mol, and the activation energy is 1.58 kcal/mol for the same beta-sheet in water.	Water	202-207	amyloid beta precursor protein	Homo sapiens	75-81
14727685-1	2003	Vasopressin has an important role in water metabolism and its impairment induces some clinical disorders such as diabetes insipidus or syndrome of inappropriate antidiuresis (SIAD).	Water	37-42	arginine vasopressin	Rattus norvegicus	0-11
15971581-10	2003	The mature apoA- I was purified from culture medium using Phenyl Sepharose hydrophobic interaction chromatography (HIC) and eluted with water and Propylene.	Water	136-141	apolipoprotein A1	Homo sapiens	11-18
14674552-6	2003	Depending on the model used and the estimated effects of composite sample collection, the 1945 arithmetic average NO3 concentration was between 44 and 57% of the expected mean value at a similar water yield during 1976-2001.	Water	195-200	NBL1, DAN family BMP antagonist	Homo sapiens	114-117
14674552-7	2003	The flow-weighted average NO3 concentration for 1945 was between 54 and 73% of the expected mean value at a similar water yield during 1976-2001.	Water	116-121	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
14580367-4	2003	In cirrhosis, COX2-prostanoid pathway may reduce formation of ascites by enhancing free water excretion, and protect gastric mucosa from ulcerative insults.	Water	88-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-18
14583292-5	2003	We report herein that bathocuproine, or its water-soluble derivative bathocuproine disulfonate, react with zinc-deficient SOD1 to form a complex which fluoresces at 734 nm when excited at 482 nm.	Water	44-49	superoxide dismutase 1, soluble	Mus musculus	122-126
14561230-1	2003	BACKGROUND: Aquaporin-1 (AQP1) functions as an osmotic water channel and a gated cation channel.	Water	55-60	aquaporin 1 (Colton blood group)	Homo sapiens	12-23
14516795-4	2003	Elimination of H(2)O(2) by catalase or N-acetyl-L-cysteine inhibited the arsenite-induced activation of p70(s6k) and ERK1/2, indicating the possible role of H(2)O(2) in the arsenite activation of the p70(s6k) and the ERK1/2 signaling pathways.	Water	15-20	mitogen-activated protein kinase 3	Homo sapiens	117-123
14516795-4	2003	Elimination of H(2)O(2) by catalase or N-acetyl-L-cysteine inhibited the arsenite-induced activation of p70(s6k) and ERK1/2, indicating the possible role of H(2)O(2) in the arsenite activation of the p70(s6k) and the ERK1/2 signaling pathways.	Water	15-20	mitogen-activated protein kinase 3	Homo sapiens	217-223
14561230-1	2003	BACKGROUND: Aquaporin-1 (AQP1) functions as an osmotic water channel and a gated cation channel.	Water	55-60	aquaporin 1 (Colton blood group)	Homo sapiens	25-29
14561474-1	2003	Two small hydrophobic proteins, SP-B and SP-C, are responsible for rapid adsorption of pulmonary surfactant to the air/water interface.	Water	119-124	surfactant protein B	Bos taurus	32-36
14561867-4	2003	We found that hyperdopaminergic DAT knockdown mutant mice have higher food and water intake.	Water	79-84	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	32-35
14504179-8	2003	Adding 1.0 mg/mL DMPC to the drinking water of 6-month-old apoE-null male mice for 8 weeks significantly reduced aortic sinus lesion area (P=0.0031) and en face whole aorta lesion area (P=0.001), whereas adding the same concentrations of soy or egg lecithin did not significantly alter lesion area.	Water	38-43	apolipoprotein E	Mus musculus	59-63
14501117-2	2003	The final refined structure of hST, comprising 5232 protein atoms, two Fe(3+) cations, two CO(3)(2-) anions, 54 water molecules and one fucose moiety, has an R factor of 21.5% and an R(free) of 26.9% for all data.	Water	112-117	fibroblast growth factor 4	Homo sapiens	31-34
14518967-0	2003	Ovalbumin, ovotransferrin, lysozyme: three model proteins for structural modifications at the air-water interface.	Water	98-103	lysozyme	Homo sapiens	27-35
14518967-1	2003	Structural modifications of ovalbumin, ovotransferrin, and lysozyme at the air-water interface have been investigated using SDS-PAGE, both intrinsic and ANS fluorometry, and circular dichroism experiments.	Water	79-84	lysozyme	Homo sapiens	59-67
12957584-0	2003	Structure and denaturation of adsorbed lysozyme at the air-water interface.	Water	59-64	lysozyme	Homo sapiens	39-47
12892664-4	2003	The results indicate that the dominant water-soluble species were SO4(2-), NO3-, NH4+, and Cl- at the four sampling sites on these days.	Water	39-44	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
12892672-4	2003	Notably, a more extensive PCB transformation was observed in the microcosms developed with site water (both without or with NaHCO3 plus Na2S), where both the initial concentration of sulfate and sulfate consumption were five fold-higher than in the corresponding microcosms with salt medium.	Water	96-101	pyruvate carboxylase	Homo sapiens	26-29
12913062-1	2003	The present study evaluated the potential mechanism involved in the hypotensive effect induced by ET-1 in rats treated with the NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) in the drinking water during 7 days.	Water	208-213	endothelin 1	Rattus norvegicus	98-102
12824077-3	2003	However, by lowering transmural urea concentration gradients, UTB reduces water efflux from DVR through aquaporin-1 (AQP1) water channels, thereby decreasing plasma sodium concentration.	Water	74-79	aquaporin 1 (Colton blood group)	Homo sapiens	104-115
12824077-3	2003	However, by lowering transmural urea concentration gradients, UTB reduces water efflux from DVR through aquaporin-1 (AQP1) water channels, thereby decreasing plasma sodium concentration.	Water	74-79	aquaporin 1 (Colton blood group)	Homo sapiens	117-121
12824077-3	2003	However, by lowering transmural urea concentration gradients, UTB reduces water efflux from DVR through aquaporin-1 (AQP1) water channels, thereby decreasing plasma sodium concentration.	Water	123-128	aquaporin 1 (Colton blood group)	Homo sapiens	104-115
12824077-3	2003	However, by lowering transmural urea concentration gradients, UTB reduces water efflux from DVR through aquaporin-1 (AQP1) water channels, thereby decreasing plasma sodium concentration.	Water	123-128	aquaporin 1 (Colton blood group)	Homo sapiens	117-121
14507725-3	2003	Scattering-length density profiles from neutron reflectivity of bovine SP-B monolayers on aqueous subphases are shown to be consistent with the exchange of a large number of labile protons as well as the inclusion of a significant amount of water, which is partly squeezed out of the protein monolayer at elevated surface pressures.	Water	241-246	surfactant protein B	Bos taurus	71-75
12923071-2	2003	Here we report for the first time that PPARgamma is expressed in human renal cortical collecting ducts (CCD), segments of the nephor involved in regulation of sodium and water homeostasis via action of the epithelial sodium channel (ENaC).	Water	170-175	peroxisome proliferator activated receptor gamma	Homo sapiens	39-48
12946442-14	2003	Our results suggested that TRD suppressed the induction of EAU by down-regulating Th1-type response in B10.A mice.	Water	59-62	negative elongation factor complex member C/D, Th1l	Mus musculus	82-85
14682945-9	2003	Using these values and a reasonable model for electrostatic and dispersion effects, the hydration free energy of water in water at 314 K is calculated to be -5.1 kcal/mole with the rPBE functional, in encouraging agreement with the experimental value of -6.1 kcal/mole.	Water	113-118	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Rattus norvegicus	181-185
12939380-10	2003	Preferential localization of AQP1 in the apical membrane of epithelial cells in the posterior intestine of seawater eel indicates that this region of the intestine is responsible for water absorption, and that AQP1 may act as a water entry site in the epithelial cells.	Water	110-115	aquaporin 1 (Colton blood group)	Homo sapiens	29-33
12939380-10	2003	Preferential localization of AQP1 in the apical membrane of epithelial cells in the posterior intestine of seawater eel indicates that this region of the intestine is responsible for water absorption, and that AQP1 may act as a water entry site in the epithelial cells.	Water	183-188	aquaporin 1 (Colton blood group)	Homo sapiens	29-33
14682945-9	2003	Using these values and a reasonable model for electrostatic and dispersion effects, the hydration free energy of water in water at 314 K is calculated to be -5.1 kcal/mole with the rPBE functional, in encouraging agreement with the experimental value of -6.1 kcal/mole.	Water	122-127	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Rattus norvegicus	181-185
14499541-4	2003	The calibrated model provides a quantitative assessment of the water and chemical fluxes transported by the rivers Derwent, Yorkshire Ouse, Wharfe, Aire, Don and Trent into the Humber estuary, i.e. a total drainage area of almost 18,000 km2 (almost 15% of the area of England) with 2,088 km of modelled river.	Water	63-68	autoimmune regulator	Homo sapiens	148-152
14499542-4	2003	The calibrated model provides a quantitative assessment of the water and chemical fluxes transported by the rivers Derwent, Yorkshire Ouse, Wharfe, Aire, Don and Trent into the Humber estuary.	Water	63-68	autoimmune regulator	Homo sapiens	148-152
14499544-1	2003	PCB congener concentrations in the water column of a highly industrialized river catchment, the Aire/Calder, in N.E.	Water	35-40	pyruvate carboxylase	Homo sapiens	0-3
14499544-1	2003	PCB congener concentrations in the water column of a highly industrialized river catchment, the Aire/Calder, in N.E.	Water	35-40	autoimmune regulator	Homo sapiens	96-100
12971758-5	2003	The controlled reaction of [U(tpa)(2)]I(3) with water resulted in the oxidation of the metal center and led to the formation of protonated tpa and of the trinuclear U(IV) oxo complex ([U(tpa)(mu-O)I](3)(mu(3)-I))I(2), 3.	Water	48-53	plasminogen activator, tissue type	Homo sapiens	30-33
13679246-0	2003	Effects of V1 and angiotensin receptor subtypes of the paraventricular nucleus on the water intake induced by vasopressin injected into the lateral septal area.	Water	86-91	arginine vasopressin	Homo sapiens	110-121
13679246-2	2003	AVP injection into the LSA increased the water intake in a dose-dependent manner.	Water	41-46	arginine vasopressin	Homo sapiens	0-3
13679246-4	2003	Both the AT(1) and AT(2) ligands administered into the PVN elicited a concentration-dependent inhibition in the water intake induced by AVP injected into the LSA, but losartan was more effective than CGP42112A the increase in the AVP response.	Water	112-117	arginine vasopressin	Homo sapiens	136-139
13679246-7	2003	These results also suggests that facilitatory effects of AVP on water intake into the LSA are mediated through the activation of V(1)-receptors and that the inhibitory effect requires V(2)-receptors.	Water	64-69	arginine vasopressin	Homo sapiens	57-60
13679246-8	2003	Based on the present findings, we suggest that the administration of AVP into the LSA may play a role in the PVN control of water control.	Water	124-129	arginine vasopressin	Homo sapiens	69-72
12972265-3	2003	Here, we use the magnetic relaxation dispersion (MRD) of the water 17O resonance to investigate the water molecules in the binding cavity of three different lipid-binding proteins: heart fatty acid-binding protein (H-FABP), ileal lipid-binding protein (I-LBP) and intestinal fatty acid-binding protein (I-FABP).	Water	100-105	fatty acid binding protein 3	Homo sapiens	181-213
12972265-3	2003	Here, we use the magnetic relaxation dispersion (MRD) of the water 17O resonance to investigate the water molecules in the binding cavity of three different lipid-binding proteins: heart fatty acid-binding protein (H-FABP), ileal lipid-binding protein (I-LBP) and intestinal fatty acid-binding protein (I-FABP).	Water	100-105	fatty acid binding protein 3	Homo sapiens	215-221
12972265-3	2003	Here, we use the magnetic relaxation dispersion (MRD) of the water 17O resonance to investigate the water molecules in the binding cavity of three different lipid-binding proteins: heart fatty acid-binding protein (H-FABP), ileal lipid-binding protein (I-LBP) and intestinal fatty acid-binding protein (I-FABP).	Water	100-105	fatty acid binding protein 2	Homo sapiens	264-301
12972265-3	2003	Here, we use the magnetic relaxation dispersion (MRD) of the water 17O resonance to investigate the water molecules in the binding cavity of three different lipid-binding proteins: heart fatty acid-binding protein (H-FABP), ileal lipid-binding protein (I-LBP) and intestinal fatty acid-binding protein (I-FABP).	Water	100-105	fatty acid binding protein 2	Homo sapiens	303-309
14621336-2	2003	Recombinant human insulin-like growth factor-I (rhIGF-I) was efficiently entrapped in poly (D,L-lactide-co-glycolide) (PLGA) microspheres by water-in-oil-in-water (W/O/W) solvent evaporation technique.	Water	141-146	insulin like growth factor 1	Homo sapiens	18-46
14621336-2	2003	Recombinant human insulin-like growth factor-I (rhIGF-I) was efficiently entrapped in poly (D,L-lactide-co-glycolide) (PLGA) microspheres by water-in-oil-in-water (W/O/W) solvent evaporation technique.	Water	157-162	insulin like growth factor 1	Homo sapiens	18-46
14604122-2	2003	Vasopressin participates in the hormonal control of water metabolism and the constriction of arterioles in humans.	Water	52-57	arginine vasopressin	Homo sapiens	0-11
14604122-3	2003	Thus, detection of vasopressin is important in diagnosing pathological conditions and physiological water metabolism.	Water	100-105	arginine vasopressin	Homo sapiens	19-30
12971758-5	2003	The controlled reaction of [U(tpa)(2)]I(3) with water resulted in the oxidation of the metal center and led to the formation of protonated tpa and of the trinuclear U(IV) oxo complex ([U(tpa)(mu-O)I](3)(mu(3)-I))I(2), 3.	Water	48-53	plasminogen activator, tissue type	Homo sapiens	139-142
12971758-5	2003	The controlled reaction of [U(tpa)(2)]I(3) with water resulted in the oxidation of the metal center and led to the formation of protonated tpa and of the trinuclear U(IV) oxo complex ([U(tpa)(mu-O)I](3)(mu(3)-I))I(2), 3.	Water	48-53	plasminogen activator, tissue type	Homo sapiens	139-142
12971758-7	2003	The pathway suggested for the formation of this complex is the oxidation of the [U(tpa)(2)]I(3) complex by H(2)O to form a U(IV) hydroxo complex which then decomposes, eliminating mono-protonated tpa.	Water	107-112	plasminogen activator, tissue type	Homo sapiens	83-86
12971758-7	2003	The pathway suggested for the formation of this complex is the oxidation of the [U(tpa)(2)]I(3) complex by H(2)O to form a U(IV) hydroxo complex which then decomposes, eliminating mono-protonated tpa.	Water	107-112	plasminogen activator, tissue type	Homo sapiens	196-199
12971758-8	2003	The comparison with the reported reaction with water of cyclopentadienyl derivatives points to a higher reactivity toward water reduction of the bis(tpa) complex with respect to the cyclopentadienyl derivatives.	Water	47-52	plasminogen activator, tissue type	Homo sapiens	149-152
12971758-8	2003	The comparison with the reported reaction with water of cyclopentadienyl derivatives points to a higher reactivity toward water reduction of the bis(tpa) complex with respect to the cyclopentadienyl derivatives.	Water	122-127	plasminogen activator, tissue type	Homo sapiens	149-152
14501358-11	2003	CONCLUSIONS: Our observed increase in ADC of lesions in pediatric patients with NF1 suggests increasing water in the extracellular space and/or decreasing cellularity with patient age.	Water	104-109	neurofibromin 1	Homo sapiens	80-83
12951051-0	2003	Reduction of chemokine IL-8 and RANTES expression in human bronchial epithelial cells by a sea-water derived saline through inhibited nuclear factor-kappaB activation.	Water	95-100	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
12950226-0	2003	Modulation of the pK(a) of metal-bound water via oxidation of thiolato sulfur in model complexes of Co(III) containing nitrile hydratase: insight into possible effect of cysteine oxidation in Co-nitrile hydratase.	Water	39-44	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	103-106
12950226-16	2003	The required presence of a Cys-sulfinic residue and one water molecule at the Co(III) site of Co-NHase as well as the optimal pH of the enzyme near 7 suggests that (i) modulation of the pK(a) of the bound water molecule at the active site of the enzyme could be one role of the oxidized Cys-S residue(s) and (ii) a cobalt-bound hydroxide could be responsible for the hydrolysis of nitriles by Co-NHase.	Water	56-61	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	81-84
12950226-16	2003	The required presence of a Cys-sulfinic residue and one water molecule at the Co(III) site of Co-NHase as well as the optimal pH of the enzyme near 7 suggests that (i) modulation of the pK(a) of the bound water molecule at the active site of the enzyme could be one role of the oxidized Cys-S residue(s) and (ii) a cobalt-bound hydroxide could be responsible for the hydrolysis of nitriles by Co-NHase.	Water	205-210	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	81-84
12922103-2	2003	Due to its poor water solubility, recombinant Escherichia coli derived VP1 (rVP1) has previously been used mainly in a denatured form and is not well characterized.	Water	16-21	claudin 3	Rattus norvegicus	71-74
12922103-2	2003	Due to its poor water solubility, recombinant Escherichia coli derived VP1 (rVP1) has previously been used mainly in a denatured form and is not well characterized.	Water	16-21	claudin 3	Rattus norvegicus	76-80
12939143-3	2003	Studies with animal models suggested that APJ and apelin play an important role in the hypothalamic regulation of water intake and the endocrine axis, in the regulation of blood pressure, and in cardiac contractility.	Water	114-119	apelin	Homo sapiens	50-56
12940901-2	2003	Many water-soluble mediators with pro- and anti-inflammatory action such as TNF, IL-6, IL-8, and IL-10 play a strategic role in septic syndrome.	Water	5-10	tumor necrosis factor	Homo sapiens	76-79
12940901-2	2003	Many water-soluble mediators with pro- and anti-inflammatory action such as TNF, IL-6, IL-8, and IL-10 play a strategic role in septic syndrome.	Water	5-10	interleukin 6	Homo sapiens	81-85
12940901-2	2003	Many water-soluble mediators with pro- and anti-inflammatory action such as TNF, IL-6, IL-8, and IL-10 play a strategic role in septic syndrome.	Water	5-10	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
12867173-9	2003	The concentrations of nitrate-nitrogen NO3--N in surface water were under the maximum contaminant level in public drinking water supplies (10 mg/l) except for one site.	Water	57-62	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
12867173-9	2003	The concentrations of nitrate-nitrogen NO3--N in surface water were under the maximum contaminant level in public drinking water supplies (10 mg/l) except for one site.	Water	123-128	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
12865045-7	2003	SOD converts superoxide into hydrogen peroxide, and catalase and GPx convert hydrogen peroxide into hydrogen oxide.	Water	100-114	catalase	Mus musculus	52-60
14612851-1	2003	AIM: Cold water-immersion induces vasoconstriction with an elevation of blood endothelin-1, which is a potent vasoconstrictor peptide, in patients with primary Raynaud"s phenomenon (PRP).	Water	10-15	endothelin 1	Homo sapiens	78-90
12813157-8	2003	In anaesthetised, water-loaded JP17 rats, hGH was released with VP in response to an acute hypovolumic stimulus (sodium nitrosopentacyano, 400 microg I.V.).	Water	18-23	arginine vasopressin	Rattus norvegicus	64-66
12939759-0	2003	Isotropic susceptibility shift under MAS: the origin of the split water resonances in 1H MAS NMR spectra of cell suspensions.	Water	66-71	inversion, Chr X, Harwell 1	Mus musculus	83-88
12954397-3	2003	Administration of NPY caused a significant increase in feeding behavior at E, but not at L. In contrast to the feeding at E, L feeding was associated with increased water intake following NPY infusion.	Water	165-170	neuropeptide Y	Rattus norvegicus	18-21
12954397-5	2003	This increased nestbox occupation was not associated with altered food intake or drinking behavior, implying that NPY-treated rats made frequent excursions between nestbox and food hopper/water bottle.	Water	188-193	neuropeptide Y	Rattus norvegicus	114-117
14681990-1	2003	Data concerning peculiarities of fermentative nature and structure of thrombin in water-salt solution have been generalized; regularities of stabilizing effect made on thrombin by various polyols and other substances have been analyzed.	Water	82-88	coagulation factor II, thrombin	Homo sapiens	70-78
12810712-8	2003	In particular, we note that residues Arg-404, Glu-290, Asp-356, and a bound water (WAT185) participate in a unique H-bonding network with the hydroxyl group ortho to the sulfuryl moiety, which may be exploited to design more potent and specific YopH inhibitors.	Water	76-81	YopH	Yersinia pestis	245-249
14766088-6	2003	Treatment with N-acetyl-L-cysteine and catalase could inhibit lens opacification, apoptosis and caspase-3 activation induced by H(2)O(2).	Water	128-133	catalase	Rattus norvegicus	39-47
12921889-4	2003	METHODS: The dams were fed increased amounts of ethanol (5% to 20%, vol/vol) in tap water for 4 wk.	Water	84-89	nuclear RNA export factor 1	Rattus norvegicus	80-83
12952342-4	2003	In addition, the presence of fog and haze in the propagation channel hampers OWC as the small water droplets scatter the propagating light.	Water	94-99	zinc finger protein, FOG family member 1	Homo sapiens	29-32
12829746-1	2003	Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells by activation of vasopressin V2 receptors and the subsequent translocation of water channels (aquaporin-2, AQP2) from intracellular vesicles into the plasma membrane.	Water	39-44	arginine vasopressin	Rattus norvegicus	9-20
12899634-1	2003	Tissue transglutaminase (TGase) catalyzes transfer of gamma-acyl moieties of Gln residues in peptides or protein substrates to either water or amine nucleophiles through an acyl-enzyme intermediate formed from initial acyl-transfer to an active site Cys residue.	Water	134-139	transglutaminase 2	Homo sapiens	0-23
12889922-1	2003	A new type of cyano-bridged Co-W bimetallic assembly, CsI[{CoII(3-cyanopyridine)2}{WV(CN)8}].H2O was synthesized.	Water	93-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-63
12967179-5	2003	Under optimum conditions, it was possible to percolate up to 250 ml of water solution onto both C18 and SDB-cation-exchange cartridges with quantitative recoveries for all the analytes tested.	Water	71-76	Bardet-Biedl syndrome 9	Homo sapiens	96-99
12967179-6	2003	However, matrix components of the surface water samples analysed negatively affected the recoveries of the analytes in the SDB-cation-exchange cartridge and thus, C18 cartridges were finally selected for the analysis of the (fluoro)quinolones in lake and river water.	Water	42-47	Bardet-Biedl syndrome 9	Homo sapiens	163-166
12846749-8	2003	The protein abundance of mTAL BSC1, NHE3, and Na+ pump increased significantly in young but remained unchanged in 7-month-old rats subjected to water deprivation.	Water	144-149	talipes	Mus musculus	25-29
12867996-8	2003	Bcl-2 overexpression reduced the generation of necrosis by H(2)O(2), but not by BSO plus cisplatin.	Water	59-64	BCL2 apoptosis regulator	Homo sapiens	0-5
12899854-5	2003	AVP and GAL responses to water-restriction differed in the two species, as did behavioral adaptations to the hot-dry season.	Water	25-30	galanin and GMAP prepropeptide	Rattus norvegicus	8-11
12899854-9	2003	The AVP response is typical of that of desert rodents, favoring survival under conditions of water-restriction.	Water	93-98	arginine vasopressin	Rattus norvegicus	4-7
12899854-13	2003	In both species, the changes in the amount of GAL-LI peptide appeared to be closely linked to changes in AVP levels, suggesting that this peptide is involved in the osmoregulatory response to water-restriction.	Water	192-197	galanin and GMAP prepropeptide	Rattus norvegicus	46-49
12759348-2	2003	Dopamine and angiotensin II have antagonistic effects on renal Na+ and water excretion, which involves regulation of the Na+,K+-ATPase activity.	Water	71-76	angiotensinogen	Homo sapiens	13-27
12889013-9	2003	The optimum formulations that yielded the highest fraction of active KGF upon release had the following general features: PLA/PGA (w/w) near unity, AOT loading of 100-200 mM, water/AOT mole ratio of 10-20, and a pH between 6 and 8.	Water	175-180	fibroblast growth factor 7	Homo sapiens	69-72
12890175-2	2003	There are conflicting reports as to the protective effect of coadministered native superoxide dismutase (SOD) and catalase against gastric mucosal lesions in rats with water immersion restraint (WIR) stress.	Water	168-173	catalase	Rattus norvegicus	114-122
12907291-7	2003	Interestingly, baicalein by itself induced an increase in H(2)O(2) generation and the subsequent NF-kappaB activation; furthermore, it effectively inhibited the transforming growth factor-beta(1) (TGF-beta(1))-induced caspase-3 activation and cell apoptosis.	Water	58-63	transforming growth factor beta 1	Homo sapiens	197-208
12854955-2	2003	In this contribution I report on two illustrative examples, p21ras and p57, revealing that such mutations have an effect on specific structural deficiencies in the packing of the protein structure, i. e., on backbone hydrogen bonds insufficiently shielded from water attack.	Water	261-266	cyclin dependent kinase inhibitor 1C	Homo sapiens	71-74
12888658-6	2003	Both 5% human fecal water and 4 micro mol/L selenite greatly increased the mRNA level of the cyclin-dependent kinase inhibitor gene p21(waf1).	Water	20-25	cyclin dependent kinase inhibitor 1A	Homo sapiens	132-135
12888658-7	2003	Interestingly, the mRNA levels of cyclin A and proliferating cell nuclear antigen (PCNA) were dramatically decreased by 69 and 62%, respectively, in HT-29 cells treated with fecal water but not selenite.	Water	180-185	cyclin A2	Homo sapiens	34-42
12884247-3	2003	In contrast, CYP2E1 expression was significantly decreased in rats with U-ARF supplied with glucose (dissolved in tap water to make 10%, w/v) in their drinking water for 5 days (U-ARFG) compared with that in rats with U-ARF.	Water	118-123	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	13-19
12884247-3	2003	In contrast, CYP2E1 expression was significantly decreased in rats with U-ARF supplied with glucose (dissolved in tap water to make 10%, w/v) in their drinking water for 5 days (U-ARFG) compared with that in rats with U-ARF.	Water	160-165	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	13-19
12902192-5	2003	However, JNK activation in response to Cr(VI) and exogenous H(2)O(2) (1 mM) shared requirements for intracellular thiol oxidation, activation of Src family kinases, and p130(cas) (Cas).	Water	60-65	mitogen-activated protein kinase 8	Homo sapiens	9-12
13679216-4	2003	On the other hand, the ANG II-induced water intake was significantly enhanced by previous injections (50 nl) into the MPO of the GABA(A) antagonist bicuculline (0.5 and 5 pmol), but not the GABA(B) antagonist phaclofen (0.05, 0.5 and 5 pmol).	Water	38-43	angiotensinogen	Rattus norvegicus	23-29
12902192-5	2003	However, JNK activation in response to Cr(VI) and exogenous H(2)O(2) (1 mM) shared requirements for intracellular thiol oxidation, activation of Src family kinases, and p130(cas) (Cas).	Water	60-65	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	145-148
12730191-6	2003	RNase protection assays showed that TTF-1 and angiotensinogen mRNA levels are simultaneously increased in the subfornical organ by water deprivation.	Water	131-136	angiotensinogen	Rattus norvegicus	46-61
12911866-11	2003	- Results showed that in normal subjects distill water caused mild elevation of blood glucose level, mild lowering of plasma insulin, and significant reduction of plasma C-peptide.	Water	49-54	insulin	Homo sapiens	125-132
12834880-4	2003	In the first and second experiments only the 100 ng AII and the 200 ng AIII increased water intake significantly.	Water	86-91	angiotensinogen	Rattus norvegicus	52-55
12834880-8	2003	Both AII and AIII increased water consumption.	Water	28-33	angiotensinogen	Rattus norvegicus	5-8
12834880-11	2003	Since, the effects of AII, AIII and angiotensin antagonists have not been tested in the zona incerta, the finding that water intake increased after AII or AIII injections and it could be blocked only by either of the antagonists suggests that AT(1) and AT(2) receptors play partially different roles in the regulation of water intake.	Water	119-124	angiotensinogen	Rattus norvegicus	27-30
12862476-7	2003	Values of pK(R) = 2.3 for the Lewis acidity constant of neutral p-quinone methide and pK(add) = -7.6 for the overall addition of solvent water to p-quinone methide to form 4-hydroxybenzyl alcohol are also reported.	Water	137-142	prokineticin receptor 2	Homo sapiens	10-19
12721285-1	2003	Mono-ADP-ribosyltransferases (ART1-7) transfer ADP-ribose from NAD+ to proteins (transferase activity) or water (NAD glycohydrolase activity).	Water	106-111	ADP-ribosyltransferase 1	Mus musculus	30-34
12848551-3	2003	The sequential water binding energies were measured to be of the order of 7-15 kcal/mol, with the largest values for the first water molecule adding to either a small nonarginine containing peptide (e.g., protonated dialanine) or to a larger peptide in a high charge state (e.g., triply protonated neurotensin).	Water	127-132	neurotensin	Homo sapiens	298-309
12874010-0	2003	Radiochemical investigations of gastrin-releasing peptide receptor-specific [(99m)Tc(X)(CO)3-Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, tumor-bearing, rodent models: syntheses, radiolabeling, and in vitro/in vivo studies where Dpr = 2,3-diaminopropionic acid and X = H2O or P(CH2OH)3.	Water	288-291	gastrin releasing peptide receptor	Homo sapiens	32-66
12848938-4	2003	When we disrupted PPK11 or PPK19 function, larvae lost their ability to discriminate low concentrations of Na(+) or K(+) from water, and the electrophysiologic responses to low salt concentrations were attenuated.	Water	126-131	pickpocket 11	Drosophila melanogaster	18-23
12822982-1	2003	In this communication, we demonstrate the feasibility of 1H detection in MAS solid-state NMR for a microcrystalline, uniformly 2H,15N-labeled sample of a SH3 domain of chicken alpha-spectrin, using pulsed field gradients for suppression of water magnetization.	Water	240-245	spectrin alpha, non-erythrocytic 1	Gallus gallus	176-190
12848938-4	2003	When we disrupted PPK11 or PPK19 function, larvae lost their ability to discriminate low concentrations of Na(+) or K(+) from water, and the electrophysiologic responses to low salt concentrations were attenuated.	Water	126-131	pickpocket 19	Drosophila melanogaster	27-32
12857090-0	2003	Two-dimensional/ATR infrared correlation spectroscopic study on water diffusion in a poly(epsilon-caprolactone) matrix.	Water	64-69	ATR serine/threonine kinase	Homo sapiens	16-19
12857090-1	2003	In the present contribution, two-dimensional ATR-FTIR spectroscopy was used to study the diffusion of water in poly(epsilon-caprolactone) (PCL).	Water	102-107	ATR serine/threonine kinase	Homo sapiens	45-48
12924622-1	2003	The renin-angiotensin system plays an important role in blood pressure regulation by influencing salt-water homeostasis and vascular tone.	Water	102-107	renin	Homo sapiens	4-9
12823559-11	2003	Whereas NoxA-1 resembles typical H2O-producing Nox enzymes that are expected to have a role in oxidative stress defence, NoxB-1 belongs to a small group of enzymes that is involved in catalysing the reduction of unsaturated acids and aldehydes, suggesting a role in fatty acid oxidation.	Water	33-36	NADPH oxidase activator 1	Homo sapiens	8-14
12826258-6	2003	This study also shows that 5IDNR, but not DNR or DXR, efficiently protects MP11 heme against degradation by H(2)O(2).	Water	108-113	non-compact myelin associated protein	Homo sapiens	75-79
12812982-6	2003	Dp71 deficiency was also associated with an impaired clustering of two Muller glial cell proteins-the inwardly rectifying potassium channel Kir4.1 and the water pore aquaporin 4 (AQP4).	Water	155-160	dystrophin, muscular dystrophy	Mus musculus	0-4
12832299-6	2003	RESULTS: The dietary intake of total as well as water-insoluble and water-soluble fiber was inversely associated with insulin resistance: -0.17 (0.07), P = 0.012; -0.15 (0.07), P = 0.024; and -0.14 (0.07), P = 0.049 [regression coefficients (SE)].	Water	48-53	insulin	Homo sapiens	118-125
12832299-6	2003	RESULTS: The dietary intake of total as well as water-insoluble and water-soluble fiber was inversely associated with insulin resistance: -0.17 (0.07), P = 0.012; -0.15 (0.07), P = 0.024; and -0.14 (0.07), P = 0.049 [regression coefficients (SE)].	Water	68-73	insulin	Homo sapiens	118-125
12884868-3	2003	We have previously shown that H2-O differentially modulates the processing and presentation of different antigenic epitopes on H2-Ab molecules.	Water	30-34	histocompatibility 2, class II antigen A, beta 1	Mus musculus	127-132
12884868-7	2003	Thus, H2-Ed/b expression influences the epitopes presented by H2-Ab, and this effect is further altered by expression of H2-O.	Water	121-125	histocompatibility 2, class II antigen A, beta 1	Mus musculus	62-67
32689047-5	2003	Injection of Xenopus oocytes with VvPIP1a cRNA induced a moderate increase of water permeability and a large increase in glycerol permeability, whereas injection with VvPIP1b cRNA did not affect these permeabilities.	Water	78-83	aquaporin PIP1-2	Vitis vinifera	34-41
12931892-1	2003	The capacity of riparian soils to remove nitrate (NO3) from ground water is well established, but the effects of ground water NO3(-)-enrichment on C dynamics are not well studied.	Water	67-72	NBL1, DAN family BMP antagonist	Homo sapiens	50-53
12820146-3	2003	This study examined the ability of osmotic agents like bovine serum albumin (BSA) to offset the water loss from the microdialysis probe.	Water	96-101	albumin	Homo sapiens	62-75
14509706-6	2003	Column studies using a 3H2O tracer and vitamin B12 in distilled water (10 microM) resulted in a B12 retardation factor (R) of approximately 2 for both sand (0.14% organic carbon) and a sandy soil (2.5% organic carbon).	Water	64-69	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	47-50
12898413-5	2003	Results showed that the water-soluble compounds, namely aucubin, chlorogenic acid, ferulic acid, p-coumaric acid and vanillic acid, enhanced the activity of human lymphocyte proliferation and secretion of IFN-gamma.	Water	24-29	interferon gamma	Homo sapiens	205-214
12893054-0	2003	Cryptic clues as to how water-soluble protein toxins form pores in membranes.	Water	24-29	cripto, FRL-1, cryptic family 1	Homo sapiens	0-7
12881590-2	2003	In peripheral epithelial tissues, sodium and water transport is regulated by corticosteroids and the 11beta-hydroxysteroid dehydrogenase (11beta-HSD) isozymes (11beta-HSD1 activating cortisol from cortisone, 11beta-HSD2 inactivating cortisol to cortisone).	Water	45-50	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	160-171
14509706-6	2003	Column studies using a 3H2O tracer and vitamin B12 in distilled water (10 microM) resulted in a B12 retardation factor (R) of approximately 2 for both sand (0.14% organic carbon) and a sandy soil (2.5% organic carbon).	Water	64-69	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	96-99
12771381-4	2003	SC water content, measured by skin conductance and 3H2O accumulation, was 3-fold lower in AQP3 null vs. wild-type mice, but became similar after topical or systemic administration of glycerol in quantities that normalized SC glycerol content.	Water	3-8	aquaporin 3	Mus musculus	90-94
12775513-11	2003	Basal intracellular production of H(2)O(2) and O(*- 2) was significantly greater in the iNOS KO compared to WT AMs.	Water	34-39	nitric oxide synthase 2, inducible	Mus musculus	88-92
12767694-5	2003	Mice were exposed to: 0, 3, 30, 3000 or 10000 parts per billion (ppb) of cadmium in tap water for 2, 4, 28, or 31 weeks.	Water	88-93	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	84-87
12623777-4	2003	Furthermore, blockade of ANG II production by an intravenous infusion of the angiotensin-converting enzyme inhibitor captopril attenuated the hypotension-induced water intake similarly in rats fed standard and high-salt diet.	Water	162-167	angiotensinogen	Rattus norvegicus	25-31
12765763-0	2003	Water-gated mechanism of proton translocation by cytochrome c oxidase.	Water	0-5	cytochrome c, somatic	Homo sapiens	49-61
12763041-4	2003	Incubation with exogenous H(2)O(2) activated tTGase.	Water	26-31	transglutaminase 2	Homo sapiens	45-51
12774023-9	2003	In conclusion, our data suggest that glucagon induces the protein kinase A and microtubule-dependent translocation of AQP8 water channels to the hepatocyte canalicular plasma membrane, which in turn leads to an increase in membrane water permeability.	Water	123-128	aquaporin 8	Rattus norvegicus	118-122
12785572-5	2003	Estimated soot-water distribution coefficients were within a factor of three of measured data for polychlorobiphenyls (PCBs) and lower molecular weight PAHs on automotive soot samples and captured the dependence of PCB distribution coefficients on the extent of ortho substitution.	Water	15-20	pyruvate carboxylase	Homo sapiens	119-122
12774023-3	2003	In this study, we tested the hypothesis that glucagon induces the trafficking of AQP8 to the hepatocyte plasma membrane and thus increases membrane water permeability.	Water	148-153	aquaporin 8	Rattus norvegicus	81-85
14586732-7	2003	RESULTS: This new equation, unlike all previous qualitative and quantitative approaches, can account mathematically for the simultaneous effects of TBW, Na(e), K(e), EMB, VMB, and the plasma glucose on the plasma water sodium concentration.	Water	213-218	embigin	Homo sapiens	166-169
12746271-2	2003	Indeed, some of the properties of the physiologically active component of the RAS, angiotensin II, include vasoconstriction, regulation of renal sodium and water absorption, and increasing thirst.	Water	156-161	angiotensinogen	Homo sapiens	83-97
12774023-9	2003	In conclusion, our data suggest that glucagon induces the protein kinase A and microtubule-dependent translocation of AQP8 water channels to the hepatocyte canalicular plasma membrane, which in turn leads to an increase in membrane water permeability.	Water	232-237	aquaporin 8	Rattus norvegicus	118-122
12833111-12	2003	Increases in subcutaneous fat water content also correlated with improvements in insulin sensitivity at 6, 9 and 12 months of weight maintenance (r=0.34-0.54, P=0.094-0.006).	Water	30-35	insulin	Homo sapiens	81-88
12676175-6	2003	Centrally administered AT(1) receptor antagonists or angiotensinogen antisense oligonucleotides inhibit sympathetic activity and reduce arterial blood pressure in certain physiological or pathophysiological conditions, as well as disrupting water drinking and sodium appetite, vasopressin secretion, sodium excretion, renin release and thermoregulation.	Water	241-246	angiotensinogen	Homo sapiens	53-68
12833111-14	2003	The increase in water content correlates with the increase in insulin sensitivity, suggesting that weight loss and consequent improved insulin sensitivity could mediate the increase in abdominal subcutaneous fat hydration.	Water	16-21	insulin	Homo sapiens	62-69
12872527-0	2003	A tap water turbidity crisis in Tel Aviv, Israel, due to technical failure: toxicological and risk management issues.	Water	6-11	ETS variant transcription factor 6	Homo sapiens	32-35
12833111-14	2003	The increase in water content correlates with the increase in insulin sensitivity, suggesting that weight loss and consequent improved insulin sensitivity could mediate the increase in abdominal subcutaneous fat hydration.	Water	16-21	insulin	Homo sapiens	135-142
12870836-9	2003	Because a higher atmospheric temperature on misty or foggy nights indicates a larger saturated amount of airborne water droplets, our results suggest that mist and fog, in particular a saturated amount of airborne water droplets, may be a stimulus for bronchoconstriction.	Water	114-119	zinc finger protein, FOG family member 1	Homo sapiens	53-56
12766090-0	2003	Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement.	Water	82-87	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
12766090-9	2003	In functional assays, AQP1 facilitated water movement across RPE monolayers in an expression-dependent manner in two complementary model systems.	Water	39-44	aquaporin 1 (Colton blood group)	Homo sapiens	22-26
12766090-10	2003	CONCLUSION: The expression of AQP1 by RPE in vivo probably contributes to the efficient transepithelial water transport across RPE, maintains retinal attachment, and prevents subretinal edema.	Water	104-109	aquaporin 1 (Colton blood group)	Homo sapiens	30-34
12730274-11	2003	The water absorption function of roots can be studied by measuring sap flow on individual root branches directly (as on crown branches) and also indirectly, by measuring the radial pattern of sap flow in different sapwood depths at the base of a stem.	Water	4-9	SH2 domain containing 1A	Homo sapiens	67-70
12730274-11	2003	The water absorption function of roots can be studied by measuring sap flow on individual root branches directly (as on crown branches) and also indirectly, by measuring the radial pattern of sap flow in different sapwood depths at the base of a stem.	Water	4-9	SH2 domain containing 1A	Homo sapiens	192-195
12870836-9	2003	Because a higher atmospheric temperature on misty or foggy nights indicates a larger saturated amount of airborne water droplets, our results suggest that mist and fog, in particular a saturated amount of airborne water droplets, may be a stimulus for bronchoconstriction.	Water	214-219	zinc finger protein, FOG family member 1	Homo sapiens	53-56
12763668-1	2003	Angiotensin II is shown by nuclear magnetic resonance (NMR) to form a complex in water at pH 4.0 with cerium(III), the ideal paramagnetic probe for Ca(2+).	Water	81-86	angiotensinogen	Homo sapiens	0-14
12754496-0	2003	Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS.	Water	27-32	superoxide dismutase 1	Homo sapiens	60-64
12810031-3	2003	Mn(TSP) is a porphyrin complex soluble in water, in contrast to most metalloporphyrins.	Water	42-47	thrombospondin 1	Homo sapiens	3-6
12754496-5	2003	Amyloid-like filaments and water-filled nanotubes arise through extensive interactions between loop and beta-barrel elements of neighboring mutant SOD1 molecules.	Water	27-32	superoxide dismutase 1, soluble	Mus musculus	147-151
15012730-10	2003	For specific conditions where renal water retention is stimulated via AVP, urinary AQP2 measurements provide a reproducible measurement of the renal actions of AVP.	Water	36-41	arginine vasopressin	Homo sapiens	70-73
15012730-10	2003	For specific conditions where renal water retention is stimulated via AVP, urinary AQP2 measurements provide a reproducible measurement of the renal actions of AVP.	Water	36-41	arginine vasopressin	Homo sapiens	160-163
12713511-0	2003	Growth hormone and prolactin responses during partial and whole body warm-water immersions.	Water	74-79	growth hormone 1	Homo sapiens	0-14
12796731-1	2003	BACKGROUND: A new dissection technique with high-pressure water stream (Hydro-Jet) has recently been applied for selective dissection during various surgical procedures.	Water	58-63	F-box and leucine rich repeat protein 15	Homo sapiens	78-81
12772918-2	2003	In the presence of [Pt(PPh3)2] the latter undergoes an addition reaction with water to afford the structurally characterised Pt(II) complex [Pt(dppe)(tBuCH2P(O)HPC(SiMe3)2].	Water	78-83	caveolin 1	Homo sapiens	23-27
12679191-4	2003	The aim of the present study was to investigate whether oral administration of trans-resveratrol to guinea pigs (60 mg/l in tap water for 16 days, ad libitum) increases cardiac DT-diaphorase and, consequently, reduces the response of isolated atria to 2-methyl-1,4-naphthoquinone (menadione), the positive inotropic effect of which is related to the amount of ROS generated by its cardiac metabolism.	Water	128-133	NAD(P)H dehydrogenase [quinone] 1	Cavia porcellus	177-190
12948840-4	2003	Water ingestion significantly enhanced the amount of the decrease in the 5-HT and 5-HIAA concentrations in the SFO area elicited by the ANG II injection.	Water	0-5	angiotensinogen	Rattus norvegicus	136-142
16256563-3	2003	As a small amount of alpha-lactalbumin is added to the mixture, there is a substantial increase (up to 80%) in the maximum water solubility in the water-in-oil microemulsion phase.	Water	123-128	lactalbumin alpha	Homo sapiens	21-38
16256563-3	2003	As a small amount of alpha-lactalbumin is added to the mixture, there is a substantial increase (up to 80%) in the maximum water solubility in the water-in-oil microemulsion phase.	Water	147-152	lactalbumin alpha	Homo sapiens	21-38
16256563-5	2003	As the molar ratio of alpha-lactalbumin to AOT surpasses approximately 1:300, the partitioning of water, protein, and surfactant shifts to the excess aqueous phase, where soluble assemblies with positive curvature are detected by dynamic light scattering.	Water	98-103	lactalbumin alpha	Homo sapiens	22-39
12800919-0	2003	Trace analysis of sulfonylurea herbicides in water by on-line continuous flow liquid membrane extraction--C18 precolumn liquid chromatography with ultraviolet absorbance detection.	Water	45-50	Bardet-Biedl syndrome 9	Homo sapiens	106-109
12713511-0	2003	Growth hormone and prolactin responses during partial and whole body warm-water immersions.	Water	74-79	prolactin	Homo sapiens	19-28
12679863-2	2003	By using this technique, conformations of four proteins, viz., beta-casein, bovine serum albumin (BSA), lysozyme, and fibrinogen in the adsorbed state at the air-water interface have been studied.	Water	162-167	fibrinogen beta chain	Homo sapiens	118-128
12676741-6	2003	The recent discoveries of aquaporin-1 (AQP1) water channels and the facilitated urea carrier UTB in DVR endothelia show that transcellular as well as paracellular pathways are involved in equilibration of DVR plasma with the interstitium.	Water	45-50	aquaporin 1 (Colton blood group)	Homo sapiens	26-37
12676741-6	2003	The recent discoveries of aquaporin-1 (AQP1) water channels and the facilitated urea carrier UTB in DVR endothelia show that transcellular as well as paracellular pathways are involved in equilibration of DVR plasma with the interstitium.	Water	45-50	aquaporin 1 (Colton blood group)	Homo sapiens	39-43
12679863-5	2003	Bovine serum albumin, which is an alpha-type protein in solution, loses its alpha-helix and becomes a disordered protein at the air-water interface.	Water	132-137	albumin	Homo sapiens	7-20
12676741-7	2003	Efflux of water across AQP1 excludes NaCl and urea, leading to the conclusion that both water abstraction and diffusion contribute to transmural equilibration.	Water	10-15	aquaporin 1 (Colton blood group)	Homo sapiens	23-27
12676741-7	2003	Efflux of water across AQP1 excludes NaCl and urea, leading to the conclusion that both water abstraction and diffusion contribute to transmural equilibration.	Water	88-93	aquaporin 1 (Colton blood group)	Homo sapiens	23-27
12606488-5	2003	The results show that AQP-9 alone caused an increase in oocyte water permeability, which could be further potentiated by CFTR.	Water	63-68	aquaporin 9	Rattus norvegicus	22-27
12606488-11	2003	We conclude that this additional role of CFTR in controlling water permeability may have an impact on the genetic disease cystic fibrosis, in which men with a mutated CFTR gene have abnormal epididymis and infertility.	Water	61-66	CF transmembrane conductance regulator	Homo sapiens	41-45
12606488-11	2003	We conclude that this additional role of CFTR in controlling water permeability may have an impact on the genetic disease cystic fibrosis, in which men with a mutated CFTR gene have abnormal epididymis and infertility.	Water	61-66	CF transmembrane conductance regulator	Homo sapiens	167-171
12770950-2	2003	2 SOD (200 U ml(-1)) increased the production of H(2)O(2) in smooth muscle cells (as indicated by the use of an H(2)O(2)-sensitive fluorescent dye).	Water	49-54	superoxide dismutase 1	Homo sapiens	2-5
12706567-1	2003	The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water.	Water	186-191	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-64
12706567-1	2003	The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water.	Water	186-191	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70
12790384-1	2003	Cardiopulmonary bypass (CPB) induces water retention in the third space, and the mechanism is partially associated with the activation of the renin-angiotensin-aldosterone system (RAAS).	Water	37-42	renin	Homo sapiens	142-147
12725837-15	2003	Similar irreversible dynamic behavior is observed for adsorption/desorption of the protein bovine serum albumin (BSA) from dilute aqueous solutions at the air/water interface.	Water	159-164	albumin	Homo sapiens	98-111
12752436-2	2003	Conformational analysis of angiotensin I (AI) and II (AII) peptides has been performed through 2D 1H-NMR spectroscopy in dimethylsulfoxide and 2,2,2-trifluoroethanol/H2O.	Water	166-169	angiotensinogen	Homo sapiens	27-52
12752436-2	2003	Conformational analysis of angiotensin I (AI) and II (AII) peptides has been performed through 2D 1H-NMR spectroscopy in dimethylsulfoxide and 2,2,2-trifluoroethanol/H2O.	Water	166-169	NLR family pyrin domain containing 3	Homo sapiens	54-57
12807177-2	2003	This prospective laboratory study evaluated the applicability of PS20 to assess the breathlessness induced by ultrasonically nebulized distilled water (UNDW) and methacholine (M) and its reproducibility.	Water	145-150	WAP four-disulfide core domain 1	Homo sapiens	65-69
12709058-8	2003	These results suggest that AVP induces the translocation of P-LAP via V2 receptor and P-LAP plays a role in the regulation of excessive AVP level in the renal collecting duct, acting as a negative feedback mechanism for the AVP action of regulating water reabsorption.	Water	249-254	arginine vasopressin	Rattus norvegicus	27-30
12709058-8	2003	These results suggest that AVP induces the translocation of P-LAP via V2 receptor and P-LAP plays a role in the regulation of excessive AVP level in the renal collecting duct, acting as a negative feedback mechanism for the AVP action of regulating water reabsorption.	Water	249-254	arginine vasopressin	Rattus norvegicus	136-139
12709058-8	2003	These results suggest that AVP induces the translocation of P-LAP via V2 receptor and P-LAP plays a role in the regulation of excessive AVP level in the renal collecting duct, acting as a negative feedback mechanism for the AVP action of regulating water reabsorption.	Water	249-254	arginine vasopressin	Rattus norvegicus	136-139
12717383-0	2003	Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis.	Water	27-32	aquaporin 8	Rattus norvegicus	15-26
12717383-1	2003	Hepatocytes express the water channel aquaporin-8 (AQP8), which is mainly localized in intracellular vesicles, and its adenosine 3",5"-cyclic monophosphate (cAMP)-induced translocation to the plasma membrane facilitates osmotic water movement during canalicular bile secretion.	Water	24-29	aquaporin 8	Rattus norvegicus	38-49
12717383-1	2003	Hepatocytes express the water channel aquaporin-8 (AQP8), which is mainly localized in intracellular vesicles, and its adenosine 3",5"-cyclic monophosphate (cAMP)-induced translocation to the plasma membrane facilitates osmotic water movement during canalicular bile secretion.	Water	24-29	aquaporin 8	Rattus norvegicus	51-55
12764601-0	2003	Structure-function relationship of reduced cytochrome c probed by complete solution structure determination in 30% acetonitrile/water solution.	Water	128-133	cytochrome c, somatic	Homo sapiens	43-55
12744428-0	2003	Geostatistical ground water monitoring of a point source NO3(-)-N plume entering a restored riparian zone.	Water	22-27	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
12744428-1	2003	NO3(-)-N concentrations associated with a point-source ground water plume were monitored as the plume entered a restored riparian zone (RRZ) on the University of Idaho campus in Moscow, Idaho.	Water	62-67	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
12672109-0	2003	Direct observations of the cleavage reaction of an L-DPPC monolayer catalyzed by phospholipase A2 and inhibited by an indole inhibitor at the air/water interface.	Water	146-151	phospholipase A2 group IB	Homo sapiens	81-97
12706543-3	2003	Actually, the binding of the paramagnetic ferric heme to the primary binding site of HSA determines a strong paramagnetic enhancement of the water (1)H NMR relaxation rate.	Water	141-146	albumin	Homo sapiens	85-88
12662361-2	2003	In the present study, we present the solution structures of neuropeptide gamma (NPgamma) from gold fish (G-NPgamma) and mammalian NPgamma (M-NPgamma), as determined by nuclear magnetic resonance (NMR) spectroscopy in 50% trifluoroethanol (TFE)/water (1 : 1, v/v) solution and 200 mm sodium dodecyl sulfate (SDS) micelles.	Water	244-249	tachykinin precursor 1	Homo sapiens	60-114
12773580-3	2003	Both groups showed transfer to familiar tap water, consuming less in context 1 than in context 2.	Water	44-49	nuclear RNA export factor 1	Rattus norvegicus	40-43
12655462-8	2003	In contrast, water intake induced by angiotensin II was unaffected by combination of pirenzepine and 4-DAMP.	Water	13-18	angiotensinogen	Rattus norvegicus	37-51
12676459-6	2003	MDR1 (P-glycoprotein) and ABCG2 preferentially extrude large hydrophobic, positively charged molecules, while the members of the MRP family can extrude both hydrophobic uncharged molecules and water-soluble anionic compounds.	Water	193-198	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
12676459-6	2003	MDR1 (P-glycoprotein) and ABCG2 preferentially extrude large hydrophobic, positively charged molecules, while the members of the MRP family can extrude both hydrophobic uncharged molecules and water-soluble anionic compounds.	Water	193-198	ATP binding cassette subfamily B member 1	Homo sapiens	6-20
12676459-6	2003	MDR1 (P-glycoprotein) and ABCG2 preferentially extrude large hydrophobic, positively charged molecules, while the members of the MRP family can extrude both hydrophobic uncharged molecules and water-soluble anionic compounds.	Water	193-198	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	26-31
12695484-0	2003	Annexin A4 reduces water and proton permeability of model membranes but does not alter aquaporin 2-mediated water transport in isolated endosomes.	Water	19-24	annexin A4	Homo sapiens	0-10
12695484-4	2003	Anx4 binding resulted in liposome aggregation and a reduction in membrane water permeability of 29% (P &lt; 0.001) at 25 degrees C. These effects were not seen in the presence of Ca2+ or Anx4 alone and were reversible with EDTA.	Water	74-79	annexin A4	Homo sapiens	0-4
12695484-7	2003	These membranes exhibited reductions to water permeability upon Anx4 binding (19.5% at 25 degrees C, 31% at 37 degrees C; P &lt; 0.01 and P &lt; 0.001, respectively) and to proton permeability (15% at 25 degrees C, 19.5% at 37 degrees C; P &lt; 0.05).	Water	40-45	annexin A4	Homo sapiens	64-68
12695484-12	2003	We conclude that Anx4 can alter the physical properties of membranes by associating with them and regulate passive membrane permeability to water and protons.	Water	140-145	annexin A4	Homo sapiens	17-21
14502981-0	2003	[Vasopressin-dependent water permeability of the basolateral membrane of the kidney outer medullary collecting duct in postnatal ontogenesis in rats].	Water	23-28	arginine vasopressin	Rattus norvegicus	1-12
12671068-7	2003	Transpiration measurements on excised rosettes and intact plants (grown in hydroponic conditions or submitted to water stress) revealed that absence of GORK activity resulted in increased water consumption.	Water	113-118	gated outwardly-rectifying K+ channel	Arabidopsis thaliana	152-156
12744320-1	2003	By deploying a functioning electrochemical cell inside a Magnetic Resonance Imaging (MRI) instrument, images of the electrically-induced diffusion of water through a Li+ ion-exchanged Nafion ionic polymer film in the form of two-dimensional maps of proton density and transverse relaxation time, T2, were generated and changes in these images over time and with respect to changes made to the applied potential were followed.	Water	150-155	cell cycle regulator of NHEJ	Homo sapiens	57-89
12672109-1	2003	The enzymatic hydrolysis of an L-dipalmitoylphosphatidylcholine (L-DPPC) monolayer at the air/water interface, catalyzed by phospholipase A(2) (PLA(2)), serves as a model for biospecific interfacial reactions.	Water	94-99	phospholipase A2 group IB	Homo sapiens	124-142
12712100-15	2003	CONCLUSION: The current study demonstrates the expression of aquaporin 8 water channel in human amnion-derived WISH cells and aquaporin 8 expression up-regulation by second messenger cyclic adenosine monophosphate.	Water	73-78	aquaporin 8	Homo sapiens	61-72
12682473-8	2003	Tumor necrosis factor-alpha was elevated at presentation (p &lt;.05), doubled by day 1 (6.98 +/- 1.36 pg/mL, p &lt;.05), remained elevated on day 3 (5.72 +/- 0.96 pg/mL, p &lt;.05), and peak levels were related to chest radiograph extravascular lung water score (r(p) = 0.64, p =.003).	Water	250-255	tumor necrosis factor	Homo sapiens	0-27
12591250-4	2003	In this paper, an authentic constituent, hydroxymethanesulfonate, is proposed as a free radical probe for the measurement of photo-chemical generation rate of OH in fog water.	Water	169-174	zinc finger protein, FOG family member 1	Homo sapiens	165-168
12591250-5	2003	At 313 nm, an apparent quantum yield for the production of OH in a fog water was found to be 0.012+/-0.001, indicating that aqueous-phase photo-chemical processes could represent a significant and may be a dominant source of OH in atmospheric liquids.	Water	71-76	zinc finger protein, FOG family member 1	Homo sapiens	67-70
12642017-5	2003	In the cortical collecting duct, AT(1) receptors stimulate transport through apical sodium channels, and in the inner medulla, urea transport is enhanced by Ang II, contributing to increased sodium and water reabsorption.	Water	202-207	angiotensinogen	Homo sapiens	157-163
12754883-2	2003	The focus on their regulatory and environmental aspects has been intensified due to the elevated levels of ammonium salts in the national water system, resulting in a banning of water use in the Dan district.	Water	138-143	NBL1, DAN family BMP antagonist	Homo sapiens	195-198
12712100-4	2003	Thus, aquaporin 8 expression represents a molecular mechanism of amniotic water absorption through intramembranous pathways.	Water	74-79	aquaporin 8	Homo sapiens	6-17
12634113-3	2003	This study investigates by means of a non-invasive technique the mechanism of coupling between transport of H(+), lactate ion, and water in the monocarboxylate transporter (MCT1) located in the apical (retinal) membrane of a mammalian RPE.	Water	131-136	solute carrier family 16 member 1	Homo sapiens	173-177
12634113-11	2003	The data suggest that H(2)O is cotransported along with H(+) and lactate ions in MCT1 localized to the retinal membrane.	Water	22-27	solute carrier family 16 member 1	Homo sapiens	81-85
12637225-5	2003	TGF-beta alone did not induce fibroblast apoptosis, but it dose-dependently augmented the apoptosis induced by exposure to H(2)O(2).	Water	123-128	transforming growth factor beta 1	Homo sapiens	0-8
12695708-1	2003	PURPOSE: To determine lysozyme deposition as a function of time in soft, high-water content, ionic (group IV) contact lenses.	Water	78-83	lysozyme	Homo sapiens	22-30
12640124-7	2003	This death-promoting influence of the PI3K/Akt pathway in caveolin-overexpressing cells appeared not to be unique to sodium arsenite, as wortmannin pretreatment also resulted in increased survival in the presence of H(2)O(2).	Water	216-221	caveolin 1	Homo sapiens	58-66
15270348-2	2003	It occurs in water naturally as As(III) and As(V).	Water	13-18	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	44-49
12701053-9	2003	Consumption of FM-VP4 by either food or drinking water routes was associated with an approximately 75% reduction in total plasma cholesterol levels and a 75% decrease in aortic atherosclerotic lesion area in ApoE-deficient mice over 12 weeks compared to controls.	Water	49-54	apolipoprotein E	Mus musculus	208-212
12679445-11	2003	In addition, PTH may be selectively more effective than PTHrP in stimulating 1,25-(OH)(2)D production, in contrast to its phosphaturic, calcemic effects and its effects to stimulate nephrogenous cAMP excretion and renal tubular calcium reabsorption.	Water	83-88	parathyroid hormone	Homo sapiens	13-16
12733644-9	2003	In conclusion, the topically applied water-soluble antioxidants ASC, NAC and CYSET protect against UVA-induced decomposition of SUP by scavenging radicals and ROS.	Water	37-42	PYD and CARD domain containing	Homo sapiens	64-67
12722151-6	2003	This study showed for the fi rst time that water extracts of S. oortiana were significantly cytotoxic to the WEHI-164 tumour cell line and increased tumour cell sensitivity to TNFalpha mediated lysis.	Water	43-48	tumor necrosis factor	Mus musculus	176-184
12639118-2	2003	Addition of aqueous H(2)O(2) to methanol solutions of the Mn(II) complexes of L(1) and L(2) produced green solutions in a fast reaction from which subsequently precipitated brown solids of the dioxo-bridged dinuclear complexes 1 and 2, respectively, which have the general formula [LMn(III)(mu-O)(2)Mn(III)L](ClO(4))(2).	Water	20-25	L1 cell adhesion molecule	Homo sapiens	78-82
12617590-0	2003	Purification and characterization of a peroxidase from corn steep water.	Water	66-71	peroxidase 1	Zea mays	39-49
12615400-0	2003	Secondary structure alterations in insulin and growth hormone water-in-oil emulsions.	Water	62-67	growth hormone 1	Homo sapiens	47-61
12644277-1	2003	Experiments were conducted to investigate the role of noradrenergic systems in the lateral hypothalamus area (LHA) in the water intake caused by injection of angiotensin II (ANG II) into the subfornical organ (SFO) in rats.	Water	122-127	angiotensinogen	Rattus norvegicus	158-172
12644277-1	2003	Experiments were conducted to investigate the role of noradrenergic systems in the lateral hypothalamus area (LHA) in the water intake caused by injection of angiotensin II (ANG II) into the subfornical organ (SFO) in rats.	Water	122-127	angiotensinogen	Rattus norvegicus	174-180
12644277-3	2003	Microinjection of ANG II into the SFO significantly increased NA release in the LHA when water was not available for drinking.	Water	89-94	angiotensinogen	Rattus norvegicus	18-24
12659192-1	2003	Near pH 2.0, lysozyme in water is in its native conformation, and in water/methanol (2/8) it adopts a helical denatured conformation (Kamatari et al.	Water	25-30	lysozyme	Homo sapiens	13-21
12659192-4	2003	Hydrogen/deuterium (H/D) exchange of lysozyme in solution confirms that it is partially unfolded at pH 2.0 in water/methanol (v/v = 2/8).	Water	110-115	lysozyme	Homo sapiens	37-45
12659192-5	2003	With electrospray ionization (ESI) mass spectrometry (MS), lysozyme in water produces ions with charges +7 to +12, with the greatest intensity at +10, whereas lysozyme in water/methanol (2/8) produces ions with charges +6 to +12 with the greatest intensity at +7.	Water	71-76	lysozyme	Homo sapiens	59-67
12659192-5	2003	With electrospray ionization (ESI) mass spectrometry (MS), lysozyme in water produces ions with charges +7 to +12, with the greatest intensity at +10, whereas lysozyme in water/methanol (2/8) produces ions with charges +6 to +12 with the greatest intensity at +7.	Water	171-176	lysozyme	Homo sapiens	159-167
12659192-11	2003	Thus, disulfide-intact gaseous lysozyme ions generated from the denatured state in water/methanol (2/8) refold into compact structures in the gas phase on a time scale of milliseconds or less.	Water	83-88	lysozyme	Homo sapiens	31-39
12617670-4	2003	Crystallization from a boiling mixture of n-PrOH and water gave 1.6n-PrOH (monoclinic, P2(1)/c), which exhibits another type of 3-D hydrogen-bonded porous network (type B) via cyclic dimers as another hydrogen-bonding motif of six primary amide groups.	Water	53-58	cyclin dependent kinase inhibitor 1A	Homo sapiens	87-94
12617590-2	2003	The major cationic corn steep water peroxidase (CSWP), with a pI &gt;10, was purified 36400-fold with a 12% recovery from late steep water by a combination of acetone and ammonium sulfate precipitation and sequential chromatography on CM-cellulose, phenyl-Sepharose, and Sephadex G-75.	Water	30-35	peroxidase 1	Zea mays	36-46
12694109-6	2003	For the immune status there was a statistically significant correlation (r=0.47, p&lt;0.05) between CD4 counts and NAA/H2O ratio.	Water	119-122	CD4 molecule	Homo sapiens	100-103
12641282-5	2003	The Hypersil BDS C18 column was the least stable under subcritical water conditions.	Water	67-72	Bardet-Biedl syndrome 9	Homo sapiens	17-20
12610210-0	2003	Comparison of formation of reactive conformers for the SN2 displacements by CH3CO2- in water and by Asp124-CO2- in a haloalkane dehalogenase.	Water	87-92	solute carrier family 38 member 5	Homo sapiens	55-58
12619050-1	2003	The following results were obtained recently from our laboratories; in rats with 72-h water deprivation (rats with dehydration), the hepatic cytochrome P450 2E1 (CYP2E1) was three-fold induced with an increase in the mRNA.	Water	86-91	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	141-160
12675337-3	2003	Through water injection, luminol and periodate were eluted from the anion-exchange column to generate the chemiluminescence, which was inhibited in the presence of lysozyme.	Water	8-13	lysozyme	Homo sapiens	164-172
12619050-1	2003	The following results were obtained recently from our laboratories; in rats with 72-h water deprivation (rats with dehydration), the hepatic cytochrome P450 2E1 (CYP2E1) was three-fold induced with an increase in the mRNA.	Water	86-91	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	162-168
12619050-2	2003	Rehydration of 48-h water-deprived rats for the next 24 h with free access of food (rats with rehydration) restored CYP2E1 level to that of control.	Water	20-25	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	116-122
12614377-9	2003	By inhibiting prostaglandin synthesis, non-steroid anti-inflammatory agents (NSAIDs) potentiate the effect of water reabsorption in the renal tubules of vasopressin, therefore enhancing water retention.	Water	110-115	arginine vasopressin	Homo sapiens	153-164
12614844-4	2003	No formation of these products was detected in the absence of one of the components of the MPO-H(2)O(2)-Cl(-) system or in the presence of MPO inhibitors (sodium azide) or scavengers of hypochlorous acid (taurine, methionine).	Water	95-100	myeloperoxidase	Homo sapiens	91-94
12641439-1	2003	Hypochlorous acid (HOCl), generated by myeloperoxidase from H(2)O(2) and Cl(-), plays an important role in host defense and inflammatory tissue injury.	Water	60-66	myeloperoxidase	Homo sapiens	39-54
12614377-9	2003	By inhibiting prostaglandin synthesis, non-steroid anti-inflammatory agents (NSAIDs) potentiate the effect of water reabsorption in the renal tubules of vasopressin, therefore enhancing water retention.	Water	186-191	arginine vasopressin	Homo sapiens	153-164
12595558-5	2003	These findings are compatible with crystallographic data showing that p52 has greater ability than p50 to form water molecule-mediated hydrogen bonds with inner nucleotide positions of the binding site.	Water	111-116	nuclear factor kappa B subunit 2	Homo sapiens	70-73
12673184-1	2003	The renin-angiotensin-aldosterone system (RAAS) exerts a principal influence in maintaining vascular tone, optimal salt and water homeostasis, and forward cardiac output in human beings.	Water	124-129	renin	Homo sapiens	4-9
12705369-4	2003	MATERIALS AND METHODS: Balb/c mice received oral insulin supplementation in their drinking water (1 U/ml) from beyond weaning during 40 days (S group).	Water	91-96	insulin	Homo sapiens	49-56
12620378-7	2003	On the other hand, when mother rats took drinking water containing 0.005% 1,4-PB-ITU for 6 days from 3 days prior to irradiation at day 21 of lactation, a low tumor incidence in the iNOS inhibitor-treated groups was observed in the 1-year period.	Water	50-55	nitric oxide synthase 2	Rattus norvegicus	182-186
12657527-4	2003	We demonstrate that continuous feeding of antigen in the drinking water, as compared to a single feeding or feeding once per day over several days enhances suppression to both Th1 and Th2 type responses in B6D2F1 and BALB/c mice.	Water	66-71	negative elongation factor complex member C/D, Th1l	Mus musculus	176-179
12708697-4	2003	A nitrate plume in shallow ground water with concentrations exceeding 10 mg NO3-N L(-1) moved into the restored forested riparian wetland.	Water	34-39	NBL1, DAN family BMP antagonist	Homo sapiens	76-79
12595558-5	2003	These findings are compatible with crystallographic data showing that p52 has greater ability than p50 to form water molecule-mediated hydrogen bonds with inner nucleotide positions of the binding site.	Water	111-116	nuclear factor kappa B subunit 1	Homo sapiens	99-102
12573807-7	2003	In conclusion, these results suggest that AII seems to be the main factor involved in the stimulation of the growth and the secretion of aldosterone by the adrenal capsule containing the zona glomerulosa during water deprivation.	Water	211-216	angiotensinogen	Rattus norvegicus	42-45
12592024-3	2003	With the use of long timescale MD simulations in explicit water, we show the role of diagonal interactions in driving the peptide to the correct folded structure (formation of the hydrophobic core with Trp 2, Tyr 4, and Phe 9 in the first stages of refolding) and in keeping it in the ensemble of folded conformations.	Water	58-63	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	202-207
12792994-2	2003	Increased unscheduled DNA synthesis was found in a dose-depend manner inducted by tap water, source water and tap water treated with 5, 10 and 15 milligrammes active carbon per liter water.	Water	86-91	nuclear RNA export factor 1	Rattus norvegicus	82-85
12792994-3	2003	The results also showed that the mutagenicity of the source water increased with the increasing of its turbidity, and mutagenicity of the tap water is higher than that of the source water as well.	Water	60-65	nuclear RNA export factor 1	Rattus norvegicus	138-141
12792994-3	2003	The results also showed that the mutagenicity of the source water increased with the increasing of its turbidity, and mutagenicity of the tap water is higher than that of the source water as well.	Water	142-147	nuclear RNA export factor 1	Rattus norvegicus	138-141
12792994-3	2003	The results also showed that the mutagenicity of the source water increased with the increasing of its turbidity, and mutagenicity of the tap water is higher than that of the source water as well.	Water	142-147	nuclear RNA export factor 1	Rattus norvegicus	138-141
12792994-5	2003	It is suggested that the development of the water treatment technics including sedimentation, filtration and treatment with active carbon is needed for decreasing or eliminating the mutagenicity of tap water.	Water	44-49	nuclear RNA export factor 1	Rattus norvegicus	198-201
12573807-2	2003	Water deprivation significantly increased plasma renin activity (PRA), plasma Angiotensin II (AII), vasopressin (AVP), epinephrine, aldosterone and corticosterone concentrations but did not modify the plasma adrenocorticotropin hormone (ACTH) level.	Water	0-5	angiotensinogen	Rattus norvegicus	78-92
12573807-2	2003	Water deprivation significantly increased plasma renin activity (PRA), plasma Angiotensin II (AII), vasopressin (AVP), epinephrine, aldosterone and corticosterone concentrations but did not modify the plasma adrenocorticotropin hormone (ACTH) level.	Water	0-5	angiotensinogen	Rattus norvegicus	94-97
12573807-2	2003	Water deprivation significantly increased plasma renin activity (PRA), plasma Angiotensin II (AII), vasopressin (AVP), epinephrine, aldosterone and corticosterone concentrations but did not modify the plasma adrenocorticotropin hormone (ACTH) level.	Water	0-5	arginine vasopressin	Rattus norvegicus	100-111
12573807-4	2003	Water deprivation significantly increased the density of AII type 1 (AT(1)) receptors in the adrenal capsule but did not modify the density of AII type 2 (AT(2)) receptors in the adrenal capsule and core containing the zona fasciculata, the zona reticularis and the medulla.	Water	0-5	angiotensinogen	Rattus norvegicus	57-60
12543463-5	2003	administration of ANG II on cardiovascular and water intake responses.	Water	47-52	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	18-24
12583753-2	2003	High-field NMR measurements on the C-ring analogue 3 in C(2)H(3)CN containing 25% (2)H(2)O have shown that it binds to the CRD2 of human PKC-alpha at virtually the same position as phorbol-13-acetate (PA) and bryostatin 1 (1).	Water	85-90	protein kinase C alpha	Homo sapiens	137-146
12598637-7	2003	Both rPP and NPY significantly increased food and water intake when they were administered into the LHA, although NPY was a more potent stimulator of food intake.	Water	50-55	neuropeptide Y	Rattus norvegicus	13-16
12638965-0	2003	Effect of water on the catalytic behaviour of VPO in the selective oxidation of propane to acrylic acid.	Water	10-15	peroxidasin	Homo sapiens	46-49
12638965-1	2003	The role of water in propane oxidation to acrylic acid is associated to slow structural modifications of VPO enhancing catalytic performances.	Water	12-17	peroxidasin	Homo sapiens	105-108
12581860-5	2003	Although NF-kappaB is known to be a redox-sensitive transcription factor, the antioxidant agents N-acetyl-cysteine (NAC) and 6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (trolox) showed no suppression and treatment with H(2)O(2) showed only slight enhancement of IFN-gamma-induced NO production.	Water	231-236	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	9-18
12557187-0	2003	Comparison of a QM/MM force field and molecular mechanics force fields in simulations of alanine and glycine "dipeptides" (Ace-Ala-Nme and Ace-Gly-Nme) in water in relation to the problem of modeling the unfolded peptide backbone in solution.	Water	155-160	angiotensin I converting enzyme	Homo sapiens	123-126
12557187-0	2003	Comparison of a QM/MM force field and molecular mechanics force fields in simulations of alanine and glycine "dipeptides" (Ace-Ala-Nme and Ace-Gly-Nme) in water in relation to the problem of modeling the unfolded peptide backbone in solution.	Water	155-160	angiotensin I converting enzyme	Homo sapiens	139-142
12543463-8	2003	administration of ANG II (10 pmol/per mouse) resulted in increased mean arterial blood pressure (MAP) and water intake in both STR/N and ICR mice, but the changes in MAP were significantly larger in STR/N mice than in ICR mice.	Water	106-111	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	18-24
12529271-8	2003	In the hydropenic kidney, DVR plasma equilibrates with the interstitium both by diffusion and through water efflux across aquaporin-1.	Water	102-107	aquaporin 1 (Colton blood group)	Homo sapiens	122-133
12553833-0	2003	Structure-function relations in self-assembled C18- and C20-sphingosines monolayers at gas/water interfaces.	Water	91-96	Bardet-Biedl syndrome 9	Homo sapiens	47-50
12553833-1	2003	Synchrotron X-ray studies and surface pressure versus molecular area (pi-A) isotherms of C18- and C20-sphingosines spread at air/water interfaces reveal unique interfacial properties with considerable differences between the two single hydrocarbon chain amino-alcohols.	Water	129-134	Bardet-Biedl syndrome 9	Homo sapiens	89-92
12553833-3	2003	The marginal affinity of C18-sphingosine to reside at the interface, the microcrystallization at very low densities, the corrugated monolayers it forms, and the strong interaction with the water surface are consistent with the roles that sphingolipids play in the life cycle of eukaryotic cells and as the building blocks of specialized membranes.	Water	189-194	Bardet-Biedl syndrome 9	Homo sapiens	25-28
12623029-9	2003	The permeation kinetics of CD34(+) cells to water and dimethyl sulphoxide were investigated at two temperatures, +1.5 and +20 degrees C. Values for the hydraulic conductivity were 3.2 x 10(-8) and 2.8 x 10(-7)cm/atm/s, respectively.	Water	44-49	CD34 molecule	Homo sapiens	27-31
12563518-1	2003	Angiotensin II and atrial natriuretic peptide (ANP) play important and opposite roles in the control of water and salt intake, with angiotensin II promoting the intake of both and ANP inhibiting the intake of both.	Water	104-109	angiotensinogen	Homo sapiens	0-14
12563518-1	2003	Angiotensin II and atrial natriuretic peptide (ANP) play important and opposite roles in the control of water and salt intake, with angiotensin II promoting the intake of both and ANP inhibiting the intake of both.	Water	104-109	natriuretic peptide A	Homo sapiens	19-45
12563518-1	2003	Angiotensin II and atrial natriuretic peptide (ANP) play important and opposite roles in the control of water and salt intake, with angiotensin II promoting the intake of both and ANP inhibiting the intake of both.	Water	104-109	natriuretic peptide A	Homo sapiens	47-50
12563518-11	2003	At the same time, the ANP released acts centrally to decrease water and salt intake.	Water	62-67	natriuretic peptide A	Homo sapiens	22-25
12553944-4	2003	In contrast to its sodium retaining properties in normal, obese and diabetic subjects, insulin-glucose-potassium therapy may induce a sodium diuresis in catabolic patients with salt and water overload and in patients with congestive heart failure in whom haemodynamic improvement has also been observed.	Water	186-191	insulin	Homo sapiens	87-94
12671583-12	2003	The presence of VIP-immunoreactive cells suggests that VIP could be produced by these cells after contact with water.	Water	111-116	vasoactive intestinal peptide	Homo sapiens	16-19
12671583-12	2003	The presence of VIP-immunoreactive cells suggests that VIP could be produced by these cells after contact with water.	Water	111-116	vasoactive intestinal peptide	Homo sapiens	55-58
12710528-8	2003	Two weeks of treatment with the angiotensin-converting enzyme (ACE) inhibitor captopril (0.5 g/L in drinking water) or the AT1-antagonist losartan (10 mg/(kg x day)) reduced cardiac hypertrophy by 54 and 42%, respectively.	Water	109-114	angiotensin I converting enzyme	Rattus norvegicus	32-61
12710188-4	2003	On intragastric administration of 10 micrograms of arginine vasopressin or 0.2 microgram of desmopressin, with water in rats, a prolonged and quite obvious antidiuretic response occurred, with a marked increase of reabsorption of the osmotically free water in kidneys.	Water	111-116	arginine vasopressin	Rattus norvegicus	60-71
12606237-3	2003	In fact, PrP(sc) is a totally dehydrated protein with an anhydrous environment, probably a thin carbon dioxide gas gap, that is why it appears highly resistant to proteases, to chemical disinfectants in water phase except in certain conditions to sodium hydroxide and sodium hypochlorite, to heat and to radiation.	Water	203-208	prion protein	Homo sapiens	9-12
12654065-6	2003	Tap water was given to the first group.	Water	4-9	nuclear RNA export factor 1	Rattus norvegicus	0-3
12592578-9	2003	The slope in the exposure-excretion regression line was almost twice as steep for MEK than for MIBK, possibly due to the difference in water solubility.	Water	135-140	mitogen-activated protein kinase kinase 7	Homo sapiens	82-85
12542607-1	2003	BACKGROUND: Vasoactive intestinal polypeptide (VIP) plays an important role in water transport in the intestine.	Water	79-84	vasoactive intestinal peptide	Homo sapiens	12-45
12542607-1	2003	BACKGROUND: Vasoactive intestinal polypeptide (VIP) plays an important role in water transport in the intestine.	Water	79-84	vasoactive intestinal peptide	Homo sapiens	47-50
12548722-1	2003	Energy landscape of a peptide, extracted from a distal beta-hairpin of src SH3 domain, in explicit water was obtained with the multicanonical molecular dynamics.	Water	99-104	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	71-74
12527803-8	2003	Phosphorylation of endothelial nitric-oxide synthase (eNOS) at serine 1179 was observed &gt;10 min after the addition of H(2)O(2), and this was prevented by wortmannin but not by PD98059.	Water	121-126	nitric oxide synthase 3	Bos taurus	19-52
12565698-1	2003	Following the discovery of the aquaporin-1 water channel in 1991, molecular techniques have been developed to examine the roles of renal aquaporins-1, -2, -3, and -4 in disorders of water balance.	Water	43-48	aquaporin 1 (Colton blood group)	Homo sapiens	31-42
12710188-4	2003	On intragastric administration of 10 micrograms of arginine vasopressin or 0.2 microgram of desmopressin, with water in rats, a prolonged and quite obvious antidiuretic response occurred, with a marked increase of reabsorption of the osmotically free water in kidneys.	Water	251-256	arginine vasopressin	Rattus norvegicus	60-71
12710188-5	2003	A direct correlation has been found between the dose of the intragastrically administered vasopressin in the dose range from 0.1 to 10 micrograms/100 g body weight and a decrease of clearance of the osmotically free water.	Water	216-221	arginine vasopressin	Rattus norvegicus	90-101
12545262-10	2003	Brain water content after transient MCAO was also significantly reduced in VEGF-treated animals compared to controls (80.9+/-0.7% vs. 83.3+/-0.6%, P&lt;0.05).	Water	6-11	vascular endothelial growth factor A	Homo sapiens	75-79
12543383-2	2003	This acylation method gave rise to a different enzyme entity (Ac-SOD) as evidenced by different physicochemical properties such as octanol/water partition coefficient and isoelectric point (pI) as compared to SOD.	Water	139-144	superoxide dismutase 1	Homo sapiens	65-68
12783701-9	2003	After being given high-salt hot water intragastrically for 4, 8, 12 weeks, the bcl-2 protein expression rates were 12.5%, 16.7%, 76.5%, the Fas protein expression rates were 18.7%, 22.2% and 64.7%.	Water	32-37	BCL2 apoptosis regulator	Homo sapiens	79-84
12513074-6	2003	The octahedral environment around each Co(II) is complemented by another singly bonded citrate belonging to the adjacent Co(II) unit and two water molecules.	Water	141-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
12515475-3	2003	Quenching of the reaction with water and workup of the product provides CTr in approximately 75% yield.	Water	31-36	calcitonin receptor	Homo sapiens	72-75
12929387-2	2003	Non-steady-state kinetic studies reveal that the SN2 reaction between p-nitrophenoxide ion and methyl iodide in acetonitrile containing water follows a 2-step mechanism involving the formation of a kinetically significant intermediate.	Water	136-141	solute carrier family 38 member 5	Homo sapiens	49-52
12473462-1	2003	Aquaporin-0 (AQP0) is the most prevalent intrinsic protein in the plasma membrane of lens fiber cells where it functions as a water selective channel and also participates in fiber-fiber adhesion.	Water	126-131	major intrinsic protein of lens fiber	Homo sapiens	0-11
12473462-1	2003	Aquaporin-0 (AQP0) is the most prevalent intrinsic protein in the plasma membrane of lens fiber cells where it functions as a water selective channel and also participates in fiber-fiber adhesion.	Water	126-131	major intrinsic protein of lens fiber	Homo sapiens	13-17
14570150-0	2003	The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake.	Water	184-189	angiotensinogen	Rattus norvegicus	53-67
14570150-0	2003	The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake.	Water	184-189	angiotensinogen	Rattus norvegicus	149-163
12493699-2	2003	Aquaporin-3 is known as a water/solute channel that can transport water and neutral solutes such as glycerol.	Water	26-31	aquaporin 3	Mus musculus	0-11
12493699-2	2003	Aquaporin-3 is known as a water/solute channel that can transport water and neutral solutes such as glycerol.	Water	66-71	aquaporin 3	Mus musculus	0-11
12493699-3	2003	In this study we examined whether artificial expression of aquaporin-3 in mouse oocytes can improve water and glycerol permeability and oocyte survival after cryopreservation.	Water	100-105	aquaporin 3	Mus musculus	59-70
12570912-8	2003	Total body water increased during GH treatment.	Water	11-16	growth hormone 1	Homo sapiens	34-36
12498798-0	2003	The structure of the aquaporin-1 water channel: a comparison between cryo-electron microscopy and X-ray crystallography.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	21-32
12498798-1	2003	Three different medium-resolution structures of the human water channel aquaporin-1 (AQP1) have been solved by cryo-electron microscopy (cryo-EM) during the last two years.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	72-83
12498798-1	2003	Three different medium-resolution structures of the human water channel aquaporin-1 (AQP1) have been solved by cryo-electron microscopy (cryo-EM) during the last two years.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	85-89
12517123-0	2003	Aerobic oxidation of methyl p-tolyl sulfide catalyzed by a remarkably labile heteroscorpionate RuII-aqua complex, fac-[RuII(H2O)(dpp)(tppm)]2+.	Water	124-127	FA complementation group C	Homo sapiens	114-117
12374804-1	2003	In renal collecting ducts, vasopressin increases the expression of and redistributes aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane, leading to urine concentration.	Water	104-109	arginine vasopressin	Rattus norvegicus	27-38
12929387-0	2003	Non-steady-state kinetic study of the SN2 reaction between p-nitrophenoxide ion and methyl iodide in aprotic solvents containing water.	Water	129-134	solute carrier family 38 member 5	Homo sapiens	38-41
12505163-5	2003	We have observed that both human Cx26 wild-type (HCx26wt) and the F83L polymorphism, found in unaffected controls, generated electrical conductance between paired Xenopus oocytes, which was several orders of magnitude greater than that measured in water-injected controls.	Water	248-253	gap junction protein beta 2	Homo sapiens	33-37
12967508-10	2003	The value of the SPF claimed on the label is diminished by environmental factors that are not taken into account during SPF measurements in the laboratory, such as sweating, water immersion, rubbing off, and photodegradation.	Water	174-179	SEC14 like lipid binding 2	Homo sapiens	17-20
15206768-10	2003	Reaching optimal conditions for tryptophan transamination measurements in vitro is generally limited by low solubility of the amino acid in water solutions: With AST preparation, the velocity of catalysed reaction at 5-50 x 10(-3) M tryptophan concentration was of 1st order to the amino acid substrate.	Water	140-145	AST	Sus scrofa	162-165
14727942-6	2003	Vasopressin reduces free water secretion and at high concentrations, causes vasoconstriction in the peripheral vasculature.	Water	25-30	arginine vasopressin	Homo sapiens	0-11
12388241-4	2003	ICV injection of ANG II also increased water intake.	Water	39-44	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	17-23
12388241-8	2003	These results indicate an antagonistic action between central AT(1)a and AT(2) receptors in the regulation of blood pressure, but they act synergistically in the regulation of water intake induced by ANG II.	Water	176-181	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	200-206
12803044-3	2003	Under oxidative conditions an ESR signal of long living nitroxil free radicals were registered in the water solution of fosmidomycin.	Water	102-107	esterase 5 regulator	Mus musculus	30-33
12874954-1	2003	The discovery of aquaporin-1 (AQP1) by Agre and colleagues explained the long-standing biophysical question of how water specifically crosses biological membranes.	Water	115-120	aquaporin 1 (Colton blood group)	Homo sapiens	17-28
12874954-1	2003	The discovery of aquaporin-1 (AQP1) by Agre and colleagues explained the long-standing biophysical question of how water specifically crosses biological membranes.	Water	115-120	aquaporin 1 (Colton blood group)	Homo sapiens	30-34
14506001-2	2003	A recent innovation has led to the recovery and concentration of water-soluble antioxidants from palm oil milling waste, characterized by its high content of phenolic acids and flavonoids.	Water	65-70	paralemmin	Homo sapiens	97-101
14506001-9	2003	A relatively new output from the oil palm fruit is the water-soluble phenolic-flavonoid-rich antioxidant complex.	Water	55-60	paralemmin	Homo sapiens	37-41
12560852-12	2003	This NHE-1 suppression may reduce an uptake of sodium chloride and water from the inflamed colonic lumen and thus contribute to diarrhea and neuromuscular alterations in these conditions.	Water	67-72	solute carrier family 9 member A1	Homo sapiens	5-10
12949671-4	2003	After pre-exposure of ganglia in the solution of potentiated water the effect of antibodies against S100 protein decreased to a lesser extent.	Water	61-66	S100 calcium binding protein A1	Homo sapiens	100-104
12713795-2	2003	We examined the possibilities that the CR2 units of CR2 complexes are associated through internal covalent links reactive with nucleophilic agents, e.g. H(2)O or methylamine, and that CR2-positive cells process anti-CR2 monoclonal antibodies (MoAbs).	Water	153-158	complement C3d receptor 2	Homo sapiens	39-42
12713795-2	2003	We examined the possibilities that the CR2 units of CR2 complexes are associated through internal covalent links reactive with nucleophilic agents, e.g. H(2)O or methylamine, and that CR2-positive cells process anti-CR2 monoclonal antibodies (MoAbs).	Water	153-158	complement C3d receptor 2	Homo sapiens	52-55
12713795-2	2003	We examined the possibilities that the CR2 units of CR2 complexes are associated through internal covalent links reactive with nucleophilic agents, e.g. H(2)O or methylamine, and that CR2-positive cells process anti-CR2 monoclonal antibodies (MoAbs).	Water	153-158	complement C3d receptor 2	Homo sapiens	52-55
12713795-2	2003	We examined the possibilities that the CR2 units of CR2 complexes are associated through internal covalent links reactive with nucleophilic agents, e.g. H(2)O or methylamine, and that CR2-positive cells process anti-CR2 monoclonal antibodies (MoAbs).	Water	153-158	complement C3d receptor 2	Homo sapiens	52-55
12685755-3	2003	C-18 solid-phase extraction technique was applied to extract organic pollutants in collected water samples.	Water	93-98	Bardet-Biedl syndrome 9	Homo sapiens	0-4
12972274-8	2003	In 1992 Agre and coworkers suggested that CHIP28 is a functional unit of membrane water channels; by reconstitution in liposomes it was demonstrated that CHIP28 is a water channel itself rather than a water channel regulator.	Water	82-87	aquaporin 1 (Colton blood group)	Homo sapiens	42-48
12972274-8	2003	In 1992 Agre and coworkers suggested that CHIP28 is a functional unit of membrane water channels; by reconstitution in liposomes it was demonstrated that CHIP28 is a water channel itself rather than a water channel regulator.	Water	82-87	aquaporin 1 (Colton blood group)	Homo sapiens	154-160
12972274-8	2003	In 1992 Agre and coworkers suggested that CHIP28 is a functional unit of membrane water channels; by reconstitution in liposomes it was demonstrated that CHIP28 is a water channel itself rather than a water channel regulator.	Water	166-171	aquaporin 1 (Colton blood group)	Homo sapiens	42-48
12972274-8	2003	In 1992 Agre and coworkers suggested that CHIP28 is a functional unit of membrane water channels; by reconstitution in liposomes it was demonstrated that CHIP28 is a water channel itself rather than a water channel regulator.	Water	166-171	aquaporin 1 (Colton blood group)	Homo sapiens	154-160
12656260-6	2003	The draining water samples (A1, B1 and C1) were obtained after decantation in laboratory of the sediments.	Water	13-18	dihydroflavonol 4-reductase	Zea mays	28-41
12789530-1	2003	PURPOSE: Investigated the effect of N-3-aminomethylbenzylacetamidine (1400 W), a highly selective inhibitor of inducible nitric oxide synthase (iNOS), on the effector phase of EAU.	Water	176-179	nitric oxide synthase 2	Rattus norvegicus	111-142
12789530-1	2003	PURPOSE: Investigated the effect of N-3-aminomethylbenzylacetamidine (1400 W), a highly selective inhibitor of inducible nitric oxide synthase (iNOS), on the effector phase of EAU.	Water	176-179	nitric oxide synthase 2	Rattus norvegicus	144-148
12669273-1	2003	Aquaporin-2, a water-channel protein, is known to increase water permeability due to vasopressin binding to V2 receptors at the renal collecting duct and is excreted into the urine.	Water	15-20	arginine vasopressin	Homo sapiens	85-96
12500203-1	2003	Hyponatremia in advanced cirrhosis and ascites or congestive heart failure (CHF) is the result of an inappropriate increase in vasopressin secretion, which acts through activation of specific V(2) receptors in the distal renal nephron to increase water reabsorption.	Water	247-252	arginine vasopressin	Homo sapiens	127-138
12487621-14	2003	However, trials with the new COX-2 inhibitors offer the chance to address these open questions of highly selective COX-2 inhibition; that is, thrombogenic risk, sodium and water retention, and interference with tissue repair, in particular, healing of mucosal damage.	Water	172-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
12504870-3	2003	The amount of water intake induced by the ANG II injection was significantly greater in the PG-treated than in the EB-treated animals.	Water	14-19	angiotensinogen	Rattus norvegicus	42-48
12506051-15	2003	CONCLUSIONS: In the early phase of EAU, the microglia migrate to the photoreceptor cell layer where they generate TNFalpha and peroxynitrite.	Water	35-38	tumor necrosis factor	Rattus norvegicus	114-122
12691004-3	2003	These two treatments were subdivided into dams that received tap water and dams that received 1.0 g/L L-NAME in tap water.	Water	116-121	nuclear RNA export factor 1	Rattus norvegicus	112-115
12696098-4	2003	In contrast, when the hemibladders were previously treated with vasopressin, the laser decreased by approximately 33.70% arginine-vasopressin (AVP)-mediated water transport.	Water	157-162	arginine vasopressin	Homo sapiens	64-75
15189662-5	2003	The increasing knowledge about aquaporins and the role of vasopressin in water metabolism has enhanced our understanding of these disorders.	Water	73-78	arginine vasopressin	Homo sapiens	58-69
15078066-10	2003	Water activity of the syrup was measured within a sugar content range of 50 to 80% degrees Brix and the sugar concentration at which the product is shelf stable was determined at 76%.	Water	0-5	biogenesis of ribosomes BRX1	Homo sapiens	91-95
12807143-4	2003	The water swelling ratio of the poly(HEMA-MAPA) beads increased significantly (68%) compared with pHEMA (55%).	Water	4-9	leucine rich repeat containing 25	Homo sapiens	42-46
12696098-4	2003	In contrast, when the hemibladders were previously treated with vasopressin, the laser decreased by approximately 33.70% arginine-vasopressin (AVP)-mediated water transport.	Water	157-162	arginine vasopressin	Homo sapiens	130-141
12972712-3	2003	METHODS: We investigated the role played by the ET-1 system in sodium and water retention and in proteinuria in puromycin aminonucleoside induced nephrotic syndrome in rats using microdissected nephron segments, competitive polymerase chain reaction, and Western blot.	Water	74-79	endothelin 1	Rattus norvegicus	48-52
12972712-10	2003	CONCLUSION: These data suggest that an activated ET-1-ET A receptor pathway in glomeruli and/or an increased ECE-1 mRNA expression in distal segments may participate in sodium and water retention, but not in the occurrence of nephrotic syndrome.	Water	180-185	endothelin converting enzyme 1	Rattus norvegicus	109-114
12608547-0	2003	Oral-antigen delivery via a water-in-oil emulsion system modulates the balance of the Th1/Th2 type response in oral tolerance.	Water	28-33	negative elongation factor complex member C/D, Th1l	Mus musculus	86-89
12608547-1	2003	PURPOSE: To evaluate the ability of a water-in-oil (W/O) emulsion containing ovalbumin (OVA), a model antigen, to induce oral tolerance and to elucidate the mechanism for the induction of oral tolerance by the emulsion system.	Water	38-43	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	77-86
12608547-1	2003	PURPOSE: To evaluate the ability of a water-in-oil (W/O) emulsion containing ovalbumin (OVA), a model antigen, to induce oral tolerance and to elucidate the mechanism for the induction of oral tolerance by the emulsion system.	Water	38-43	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	88-91
12540960-1	2003	An amidrazonophenylalanine derivative, LB30057, inhibits the catalytic activity of thrombin potently by interaction with the active site of thrombin, and has high water solubility.	Water	163-168	coagulation factor II, thrombin	Homo sapiens	83-91
12590385-3	2003	Using this tandem LC-LC/APPI-MS system the extraction, separation and selective detection of PFOS in river water could be achieved with satisfactory selectivity and sensitivity.	Water	107-112	amyloid beta precursor protein	Homo sapiens	24-28
12475328-5	2002	For the suppression of phosphate elimination in TIM, the calculations show that the widely accepted stereoelectronic argument that invokes the different phosphoryl torsion angles observed in the X-ray structures of inhibitor complexes of the two enzymes is not as important as electrostatic contributions from the protein and water molecules surrounding the phosphoryl.	Water	326-331	triosephosphate isomerase 1	Homo sapiens	48-51
12813912-9	2003	Study of GC-C "knock-out" mice reveal that GC-C is important to intestinal salt and water secretion, duodenal bicarbonate secretion, recovery from CCl4-induced liver injury, and to intestinal polyp formation in Min mice lacking GC-C.	Water	84-89	guanylate cyclase 2c	Mus musculus	43-47
12884579-4	2003	The water level inside and outside of the dike was recorded from 1995 to 2002, and the relationship between the water level and snail population at the inside of the dike was analyzed.	Water	112-117	snail family transcriptional repressor 1	Homo sapiens	128-133
12470072-4	2002	The formation of 1 is proposed to involve the intermediacy of Ln(Tp(Me2))(2)OH formed by protonolysis with adventitious water.	Water	120-125	malic enzyme 2	Homo sapiens	68-71
12813912-9	2003	Study of GC-C "knock-out" mice reveal that GC-C is important to intestinal salt and water secretion, duodenal bicarbonate secretion, recovery from CCl4-induced liver injury, and to intestinal polyp formation in Min mice lacking GC-C.	Water	84-89	guanylate cyclase 2c	Mus musculus	43-47
12639008-0	2003	The use of IL-6 induction as a human biomarker for inflammatory agents in water.	Water	74-79	interleukin 6	Homo sapiens	11-15
12639008-4	2003	Water contaminated with inflammatory substances induced the pro-inflammatory hormone interleukin 6 (IL-6).	Water	0-5	interleukin 6	Homo sapiens	85-98
12639008-4	2003	Water contaminated with inflammatory substances induced the pro-inflammatory hormone interleukin 6 (IL-6).	Water	0-5	interleukin 6	Homo sapiens	100-104
12639008-5	2003	All water samples collected from the Modder River induced IL-6 secretion, and the quantity of IL-6 secreted was dependent on the concentration and origin of the sample.	Water	4-9	interleukin 6	Homo sapiens	58-62
12445856-0	2002	Cholesteryl ester transfer protein facilitates the movement of water-insoluble drugs between lipoproteins: a novel biological function for a well-characterized lipid transfer protein.	Water	63-68	cholesteryl ester transfer protein	Homo sapiens	0-34
12485466-6	2002	RESULTS: Treatment of cells with water extract of Puerariae radix significantly decreased apoB100 production and secretion from HepG2 cells up to 66% in a dose dependent manner.	Water	33-38	apolipoprotein B	Homo sapiens	90-97
12485466-8	2002	In contrast, water extract of Puerariae radix attenuated apoB48 concentrations in cells, but not apoB48 secretion from CaCo2 enterocytes.	Water	13-18	apolipoprotein B	Homo sapiens	57-63
12445856-1	2002	This review article addresses the recently discovered finding that cholesteryl ester transfer protein (CETP) can facilitate the transfer of water-insoluble drugs between different lipoprotein subclasses.	Water	140-145	cholesteryl ester transfer protein	Homo sapiens	67-101
12471059-3	2002	We developed a new transgenic mouse model where muscle specific utrophin expression was conditioned by addition of tetracycline in water.	Water	131-136	utrophin	Mus musculus	64-72
12445856-1	2002	This review article addresses the recently discovered finding that cholesteryl ester transfer protein (CETP) can facilitate the transfer of water-insoluble drugs between different lipoprotein subclasses.	Water	140-145	cholesteryl ester transfer protein	Homo sapiens	103-107
12445856-4	2002	The human body appears to recognize exogenous water-insoluble drugs as lipid-like particles, which suggests that these compounds may interact with lipoproteins just like endogenous plasma lipids, and thus their transfer between lipoproteins may be facilitated by plasma CETP.	Water	46-51	cholesteryl ester transfer protein	Homo sapiens	270-274
12388410-9	2002	However, the UPIII-deficient apical membrane has a significantly elevated water permeability (normal 0.91 +/- 0.06, knockout 1.83 +/- 0.14 cm/s x 10(-5); P &lt; 0.05).	Water	74-79	uroplakin 3A	Mus musculus	13-18
12468218-1	2002	Human serum albumin (HSA) was encapsulated as a model protein in microspheres of biodegradable and biocompatible polymers by the water-in-oil-in-water (w/o/w) emulsion solvent extraction/evaporation (double emulsion) technique for purpose of controlled release.	Water	129-134	albumin	Homo sapiens	6-25
12468218-1	2002	Human serum albumin (HSA) was encapsulated as a model protein in microspheres of biodegradable and biocompatible polymers by the water-in-oil-in-water (w/o/w) emulsion solvent extraction/evaporation (double emulsion) technique for purpose of controlled release.	Water	145-150	albumin	Homo sapiens	6-25
12452712-3	2002	A large common ion rate depression for the reaction of the chlorohydrin was observed, and the rate data are fit to a mechanism in which all of the tetrol products are formed by the reaction of water with the C-10 carbocation intermediate.	Water	193-198	homeobox C10	Homo sapiens	208-212
12432546-3	2002	A single intravenous injection of a soluble recombinant TGF-beta receptor type II-murine Fc:IgG(2A) chimeric protein that specifically inhibits TGF-beta1 and -beta3, significantly lowered TIFP in a time and concentration dependent manner but did not change total tissue water content in the tumors.	Water	270-275	transforming growth factor beta 1	Homo sapiens	144-164
12444757-0	2002	Interligand interactions controlling the mu-N7,N9-metal bonding of adenine (AdeH) to the N-benzyliminodiacetato(2-) copper(II) chelate and promoting the N9 versus N3 tautomeric proton transfer: molecular and crystal structure of [Cu2(NBzIDA)(2)(H2O)(2)(mu-N7,N9-Ade(N3)H)].(3)H2O.	Water	245-248	adenylosuccinate synthase 2	Homo sapiens	76-80
12444757-0	2002	Interligand interactions controlling the mu-N7,N9-metal bonding of adenine (AdeH) to the N-benzyliminodiacetato(2-) copper(II) chelate and promoting the N9 versus N3 tautomeric proton transfer: molecular and crystal structure of [Cu2(NBzIDA)(2)(H2O)(2)(mu-N7,N9-Ade(N3)H)].(3)H2O.	Water	276-279	adenylosuccinate synthase 2	Homo sapiens	76-80
12573139-1	2002	Angiotensin II has been shown to participate in both physiological processes, such as sodium and water homeostasis and vascular contraction, and pathophysiological processes, including atherosclerosis and hypertension.	Water	97-102	angiotensinogen	Homo sapiens	0-14
12468373-5	2002	RESULTS: We found that distilled water, minerals, and vitamins had low Brix values of 0+/-0, 1.2+/-0.1, and 0.4+/-0.1, respectively.	Water	33-38	biogenesis of ribosomes BRX1	Homo sapiens	71-75
12510842-1	2002	Previous study showed that an amidrazonophenylalanine derivative, LB30057, which has high water solubility, inhibited the catalytic activity of thrombin potently by interaction with the active site of thrombin.	Water	90-95	coagulation factor II, thrombin	Homo sapiens	144-152
12510842-1	2002	Previous study showed that an amidrazonophenylalanine derivative, LB30057, which has high water solubility, inhibited the catalytic activity of thrombin potently by interaction with the active site of thrombin.	Water	90-95	coagulation factor II, thrombin	Homo sapiens	201-209
12457460-26	2002	Perinatal malnutrition also affects the responsiveness to water deprivation with alterations in both hypothalamic VP gene expression and regulation of ANP-binding sites.	Water	58-63	arginine vasopressin	Rattus norvegicus	114-116
12458365-1	2002	The aim of this investigation was to examine the effect of water ingestion on physiological responses to prolonged cycling (CYC) and running (RUN).	Water	59-64	cytochrome c, somatic	Homo sapiens	124-127
12602343-2	2002	With the Onsager approach to account for the variation in local dielectric constant, these results are used to determine the effective penetration profile of water into fluid phospholipid membranes, from recent electron paramagnetic resonance (EPR) studies on phospholipids spin-labelled systematically down the sn-2 chain.	Water	158-163	solute carrier family 38 member 5	Homo sapiens	312-316
12523409-7	2002	This indicates that water column transport driven by tidal exchange is a viable mechanism reducing PCB contamination within SDB.	Water	20-25	pyruvate carboxylase	Homo sapiens	99-102
12433939-7	2002	In the airways, AQP3 and AQP4 facilitate water transport; however, airway hydration, regulation of the airway surface liquid layer, and isosmolar fluid absorption are not impaired by AQP deletion.	Water	41-46	aquaporin 3	Mus musculus	16-20
12427016-10	2002	This view is also supported by the results of molecular dynamics simulations conducted for 18 ns on free thrombin in full explicit water, showing that after approximately 5 ns thrombin undergoes a significant conformational transition, from a more open conformation (which we propose can be related to the fast form) to a more compact and closed one (which we propose can be related to the slow form).	Water	131-136	coagulation factor II, thrombin	Homo sapiens	105-113
12395425-4	2002	Most approaches support the critical role of Glu-166 and hydrolytic water in the acylation step of the enzymatic catalysis in class A beta-lactamases.	Water	68-73	amyloid beta precursor protein	Homo sapiens	132-138
12523665-6	2002	CONCLUSION: The results indicate that the stabilization of catalase and lysozyme by excipients during dehydration was mainly due to water substitution rather than the formation of glass; the latter appearing not to be a prerequisite during freeze-drying.	Water	132-137	catalase	Homo sapiens	59-67
12535695-4	2002	The increase in the NA concentration caused by the ANG II injection was significantly attenuated by water ingestion.	Water	100-105	angiotensinogen	Rattus norvegicus	51-57
12270942-1	2002	Deletion of the epidermal water/glycerol transporter aquaporin-3 (AQP3) in mice reduced superficial skin conductance by approximately 2-fold (Ma, T., Hara, M., Sougrat, R., Verbavatz, J. M., and Verkman, A. S. (2002) J. Biol.	Water	26-31	aquaporin 3	Mus musculus	53-64
12270942-1	2002	Deletion of the epidermal water/glycerol transporter aquaporin-3 (AQP3) in mice reduced superficial skin conductance by approximately 2-fold (Ma, T., Hara, M., Sougrat, R., Verbavatz, J. M., and Verkman, A. S. (2002) J. Biol.	Water	26-31	aquaporin 3	Mus musculus	66-70
12270942-5	2002	Utilizing a novel (3)H(2)O distribution method, SC water content was reduced by approximately 50% in AQP3 null mice.	Water	51-56	aquaporin 3	Mus musculus	101-105
12270942-7	2002	Although basal skin barrier function was not impaired, AQP3 deletion produced an approximately 2-fold delay in recovery of barrier function as measured by transepidermal water loss after tape stripping.	Water	170-175	aquaporin 3	Mus musculus	55-59
12454260-8	2002	In the inactive conformation, the lid covers the active site and, upon activation by bile salt micelles and colipase or by lipid-water interfaces, the lid moves dramatically to open and configure the active site.	Water	129-134	colipase	Homo sapiens	108-116
12454260-9	2002	After the lid movement, PTL and colipase create a large hydrophobic plateau that can interact with the lipid-water interface.	Water	109-114	colipase	Homo sapiens	32-40
12457773-1	2002	Aquaporin-1 (AQP1) is a member of the diverse major intrinsic protein family of water and solute channels.	Water	80-85	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
12457773-1	2002	Aquaporin-1 (AQP1) is a member of the diverse major intrinsic protein family of water and solute channels.	Water	80-85	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
12457773-2	2002	AQP1 is known as an osmotic water channel in kidney, brain, vascular system and other tissues, and recently has been demonstrated to function as a cation channel gated by cGMP.	Water	28-33	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
12457773-5	2002	Distinct pathways for fluxes of water and ions in the tetrameric AQP1 channel indicate an intriguing multifunctional capacity.	Water	32-37	aquaporin 1 (Colton blood group)	Homo sapiens	65-69
12427016-10	2002	This view is also supported by the results of molecular dynamics simulations conducted for 18 ns on free thrombin in full explicit water, showing that after approximately 5 ns thrombin undergoes a significant conformational transition, from a more open conformation (which we propose can be related to the fast form) to a more compact and closed one (which we propose can be related to the slow form).	Water	131-136	coagulation factor II, thrombin	Homo sapiens	176-184
12425618-0	2002	Ferromagnetic coupling between low- and high-spin iron(III) ions in the tetranuclear complex fac-[[FeIII[HB(pz)3](CN)2(mu-CN)]3FeIII(H2O)3]* 6H2O ([HB(pz)3]- = hydrotris(1-pyrazolyl)borate).	Water	133-136	FA complementation group C	Homo sapiens	93-96
12214315-0	2002	Hydration structure of human lysozyme investigated by molecular dynamics simulation and cryogenic X-ray crystal structure analyses: on the correlation between crystal water sites, solvent density, and solvent dipole.	Water	167-172	lysozyme	Homo sapiens	29-37
12520852-4	2002	In the evaluation of the results of the diagnostic procedures, it is to be considered that long-term overhydration of any origin suppresses the vasopressin secretion and the "washout" effect of the long-term water-diuresis decreases the concentration gradient of the renal medulla leading to blunted sensitivity towards vasopressin.	Water	208-213	arginine vasopressin	Homo sapiens	320-331
12416988-0	2002	Structure of rhodopsin in monolayers at the air-water interface: a PM-IRRAS and X-ray reflectivity study.	Water	48-53	rhodopsin	Homo sapiens	13-22
12223490-4	2002	We found that JNK phosphorylated Ser-121 and Thr-163 of Mcl-1 in response to stimulation with H(2)O(2) and that transfection of unphosphorylatable Mcl-1 resulted in an enhanced anti-apoptotic activity in response to stimulation with H(2)O(2).	Water	94-99	mitogen-activated protein kinase 8	Homo sapiens	14-17
12223490-4	2002	We found that JNK phosphorylated Ser-121 and Thr-163 of Mcl-1 in response to stimulation with H(2)O(2) and that transfection of unphosphorylatable Mcl-1 resulted in an enhanced anti-apoptotic activity in response to stimulation with H(2)O(2).	Water	233-238	mitogen-activated protein kinase 8	Homo sapiens	14-17
12416988-1	2002	Monomolecular films of the membrane protein rhodopsin have been investigated in situ at the air-water interface by polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) and X-ray reflectivity in order to find conditions that retain the protein secondary structure.	Water	96-101	rhodopsin	Homo sapiens	44-53
12372793-1	2002	AVP increases the osmotic water permeability of renal collecting ducts by inducing the translocation of specific aquaporin-2 (AQP2) water channels from cytoplasmic vesicles to the apical plasma membrane of the principal cells.	Water	26-31	arginine vasopressin	Rattus norvegicus	0-3
18968817-7	2002	The developed method was applied to Pb(II) determination in natural water and foodstuffs.	Water	68-73	submaxillary gland androgen regulated protein 3B	Homo sapiens	36-42
12372803-2	2002	Reductions in either cell volume or cytosolic Cl(-) concentration ([Cl(-)](i)) stimulate a corrective uptake of KCl and water via NKCC, whereas cell swelling triggers KCl loss via KCC.	Water	120-125	solute carrier family 12 member 1	Homo sapiens	130-134
12372772-8	2002	The data suggest that increases in TNF production subsequent to activation of the CaR may be the basis of an important renal mechanism that regulates salt and water excretion.	Water	159-164	tumor necrosis factor	Homo sapiens	35-38
12372793-1	2002	AVP increases the osmotic water permeability of renal collecting ducts by inducing the translocation of specific aquaporin-2 (AQP2) water channels from cytoplasmic vesicles to the apical plasma membrane of the principal cells.	Water	132-137	arginine vasopressin	Rattus norvegicus	0-3
13677623-14	2002	SOD converts O2*- to H2O2, which is further converted to H2O with the help of GPx and CAT.	Water	21-24	superoxide dismutase 1	Homo sapiens	0-3
12376400-8	2002	At the same time, other ANG II-specific brain mechanisms concerned with water intake, food intake, vasopressin release, ACTH release, and blood pressure regulation appear to have been activated by the same type of synergy.	Water	72-77	angiotensinogen	Rattus norvegicus	24-30
12367775-3	2002	METHODS: Tap water containing ethanol at the concentration of 25% (v/v) and phenobarbital (500 mg/l) was the only source of drinking water for the experimental rats for 24 months.	Water	13-18	nuclear RNA export factor 1	Rattus norvegicus	9-12
12367775-3	2002	METHODS: Tap water containing ethanol at the concentration of 25% (v/v) and phenobarbital (500 mg/l) was the only source of drinking water for the experimental rats for 24 months.	Water	133-138	nuclear RNA export factor 1	Rattus norvegicus	9-12
19003111-3	2002	Water-soluble or chloroform/methanol-extracted fractions from Kefram-Kefir were examined to evaluate the glucose uptake ability of L6 myotubes.As a result, the water-soluble fraction augmented the uptake of glucose in L6 myotubes both in the presence and absence of insulin stimulation.	Water	160-165	insulin	Homo sapiens	266-273
19003111-5	2002	Especially, glucose uptake was augmented up to six times with the addition of water-soluble fraction in the insulin-stimulated L6 myotubes.	Water	78-83	insulin	Homo sapiens	108-115
19003111-8	2002	Considering together with the reports that PI 3-kinase is locatedin the insulin signaling pathway and the participation in the translocation of glucose transporter 4 to the cell membrane, it is suggested that the water-soluble fraction of Kefram-Kefir activates PI 3-kinase or other upstream molecules in the insulin signaling pathway, which resulted in the augmentation of glucose uptake and its specific inhibition by wortmannin.	Water	213-218	insulin	Homo sapiens	72-79
19003111-8	2002	Considering together with the reports that PI 3-kinase is locatedin the insulin signaling pathway and the participation in the translocation of glucose transporter 4 to the cell membrane, it is suggested that the water-soluble fraction of Kefram-Kefir activates PI 3-kinase or other upstream molecules in the insulin signaling pathway, which resulted in the augmentation of glucose uptake and its specific inhibition by wortmannin.	Water	213-218	insulin	Homo sapiens	309-316
12381518-3	2002	In passage 1 culture of rat HSCs, TGF-beta1 induced a concentration-dependent increase in procollagen-alpha(1)(I) mRNA levels and enhanced intracellular H(2)O(2) and superoxide anion formation and lipid peroxidation but decreased GSH levels.	Water	153-158	transforming growth factor, beta 1	Rattus norvegicus	34-43
12434255-1	2002	A heated electrospray interface that affords high sensitivity and long-term signal stability for AAS detection of metal-containing analytes in organic or organic-water solvents after HPLC separation is described.	Water	162-167	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	97-100
12390971-5	2002	Furthermore, a significant reduction in tissue water diffusion was apparent 24 h after intrastriatal injection of TNF-alpha injection, which may indicate compromise of tissue energy metabolism.	Water	47-52	tumor necrosis factor	Homo sapiens	114-123
12464972-3	2002	Polaprezinc and zinc sulphate inhibited IL-8 production by MKN 45 cells in response to stimulation with H pylori water extract (HPE) in a dose-dependent manner from 10(-7) M to 10(-5) M. In addition, the expression of CD11b and CD18 on PMN and PMN-dependent adhesion to endothelial cells elicited by HPE was inhibited by polaprezinc and zinc sulphate in a concentration-dependent manner.	Water	113-118	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
12457863-1	2002	To understand why the water channel aquaporin-0 (AQP0) replaces aquaporin-1(AQP1) during lens development, we studied its spatial arrangement and interactions with proteins in the plasma membrane of equatorial fibers.	Water	22-27	major intrinsic protein of lens fiber	Homo sapiens	49-53
12592900-6	2002	A course intake of mineral water raised tissue sensitivity to insulin at early stages of glucose test and lowered basal level of insulin and hydrocortisone.	Water	27-32	insulin	Homo sapiens	62-69
12572868-6	2002	RESULTS: The analysis of downregulated genes in the DSS mice following PPARgamma administration revealed several functional gene clusters with altered expression: (1) oncogene families such as GRO1 oncogenes, (2) inflammatory mediator-related genes such as the interferon-gamma gene, (3) water electrolyte-associated genes, and (4) others.	Water	288-293	chemokine (C-X-C motif) ligand 1	Mus musculus	193-197
12558060-4	2002	Any traces of conjugated bile acids are hydrolyzed before the C18 extraction by deconjugating enzymes, which are present in feces and are activated by the addition of water during the homogenization step.	Water	167-172	Bardet-Biedl syndrome 9	Homo sapiens	62-65
12592900-6	2002	A course intake of mineral water raised tissue sensitivity to insulin at early stages of glucose test and lowered basal level of insulin and hydrocortisone.	Water	27-32	insulin	Homo sapiens	129-136
12924029-0	2002	[Conformational changes in HIV-1 proteinase: effect of protonation of the active center on conformation of HIV-1 proteinase in water].	Water	127-132	endogenous retrovirus group K member 25	Homo sapiens	33-43
12924029-0	2002	[Conformational changes in HIV-1 proteinase: effect of protonation of the active center on conformation of HIV-1 proteinase in water].	Water	127-132	endogenous retrovirus group K member 25	Homo sapiens	113-123
12373455-1	2002	The well-documented efficacy of HI 6 dichloride in reactivating acetylcholinesterase (AChE) inhibited by nerve agents is curtailed by its poor water-solubility at temperatures below 10 degrees C. This drawback can be circumvented by using HI 6 dimethanesulfonate, which has been developed in our laboratory.	Water	143-148	acetylcholinesterase (Cartwright blood group)	Homo sapiens	86-90
12401197-1	2002	Secretory phospholipase A2 (PLA2) is a ubiquitous water-soluble enzyme found in venom, pancreatic, and cancerous fluid.	Water	50-55	phospholipase A2 group IB	Homo sapiens	10-26
12401197-1	2002	Secretory phospholipase A2 (PLA2) is a ubiquitous water-soluble enzyme found in venom, pancreatic, and cancerous fluid.	Water	50-55	phospholipase A2 group IB	Homo sapiens	28-32
12192003-5	2002	AQPxlo expression increased osmotic water permeability (P(f)), as well as the uptake of glycerol and urea.	Water	36-41	aquaporin 10 L homeolog	Xenopus laevis	0-6
12496014-1	2002	The phenomenon of ice-particle/water mixture blocking flow through a pipeline is a problem that needs to be solved before mixture flow can be applied for practical use in cold energy transportation in a district cooling system.	Water	31-36	carboxylesterase 2	Homo sapiens	18-21
12358536-4	2002	When deposited on an electrode surface, they catalyze the selective reduction of O(2) to H(2)O at potentials comparable to the midpoint potential of cytochrome c.	Water	89-94	cytochrome c, somatic	Homo sapiens	149-161
12388974-2	2002	Specifically, aquaporin 1 (AQP1) and aquaporin 3 (AQP3) have been found to be important in osmotic water movement across membranes.	Water	99-104	aquaporin 1 (Colton blood group)	Homo sapiens	14-25
12388974-2	2002	Specifically, aquaporin 1 (AQP1) and aquaporin 3 (AQP3) have been found to be important in osmotic water movement across membranes.	Water	99-104	aquaporin 1 (Colton blood group)	Homo sapiens	27-31
12388974-13	2002	AQP1 may play a role in water movement from the amniotic cavity across the placenta into the fetal circulation.	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
32689576-7	2002	Heat-shock protein calmodulin-binding homolog was induced by water stress in drought-tolerant varieties (Eva and Siokra L23) and Zeta 2.	Water	61-66	calmodulin 1	Homo sapiens	19-29
12162325-3	2002	At first these matrices were partially hydrolyzed and then the carboxyl groups were coupled with RGD or insulin in the presence of water-soluble carbodiimide.	Water	131-136	insulin	Homo sapiens	104-111
12395896-1	2002	The aim of this study was to assess whether colitis induced by dextran sulfate sodium (DSS; 10% in tap water for 7 days) in BALB/c mice is associated with changes in intestinal blood flow.	Water	103-108	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	99-102
12430955-11	2002	In cystic fibrosis, gland serous cells cannot secrete water because they lack functioning CFTR in their apical membranes (CFTR is the cystic fibrosis transmembrane conductance regulator, a Cl channel that is abundant in serous cells).	Water	54-59	CF transmembrane conductance regulator	Homo sapiens	122-126
12650588-3	2002	Molecular models of the complexes formed by indomethacin, sulindac, fenamates, 2-phenylpropionic acids and selective cyclooxygenase-2 (COX-2) inhibitors with the cyclooxygenase active site of human PGHS-2 have been built, paying particular attention to water molecules that participate in the hydrogen-bonding network at the polar active site entrance.	Water	253-258	prostaglandin-endoperoxide synthase 2	Homo sapiens	135-140
12354070-1	2002	We have performed an 4-ns MD simulation of calmodulin complexed with a target peptide in explicit water, under realistic conditions of constant temperature and pressure, in the presence of a physiological concentration of counterions and using Ewald summation to avoid truncation of long-range electrostatic forces.	Water	98-103	calmodulin 1	Homo sapiens	43-53
12601975-6	2002	METHODS: Thirty-two adult Wistar rats fed orally with standard rat chow and tap water "ad libitum" were maintained individual metabolic cages for ten days after 80% gut resection from the duodeno-jejunal angle to 10 cm above the cecum and divided in two groups: -Group A (n = 14): served as control.	Water	80-85	nuclear RNA export factor 1	Rattus norvegicus	76-79
12218304-1	2002	AIM: To determine whether glucose, NaCl and/or cholera toxin modify the expression of aquaporin-1 (AQP-1) water channel.	Water	106-111	aquaporin 1 (Colton blood group)	Homo sapiens	86-97
12908278-2	2002	The water-soluble samples were used as starting materials in reactions with bovine serum albumin (BSA) protein in ambient aqueous solutions.	Water	4-9	albumin	Homo sapiens	83-102
12352363-2	2002	Previously, we demonstrated that renal fibrosis was decreased after 2 weeks of unilateral ureteral obstruction in inducible nitric oxide synthase (iNOS) knock-out mice given L-arginine supplemented drinking water.	Water	207-212	nitric oxide synthase 2, inducible	Mus musculus	114-145
12352363-2	2002	Previously, we demonstrated that renal fibrosis was decreased after 2 weeks of unilateral ureteral obstruction in inducible nitric oxide synthase (iNOS) knock-out mice given L-arginine supplemented drinking water.	Water	207-212	nitric oxide synthase 2, inducible	Mus musculus	147-151
12218304-1	2002	AIM: To determine whether glucose, NaCl and/or cholera toxin modify the expression of aquaporin-1 (AQP-1) water channel.	Water	106-111	aquaporin 1 (Colton blood group)	Homo sapiens	99-104
12218304-5	2002	Hyperosmolar Reno-60 and Hypaque-76 contrast agents at 500 mosm/kg.H(2)O and isomolar Visipaque at 25% (v/v) concentration(s) also increased AQP-1 expression 3.8- to 5.0-fold (p &lt; 0.01) in HRPTE cells which also were inhibited by cholera toxin from 41% (p &lt; 0.05) to 71% (p &lt; 0.01).	Water	67-72	aquaporin 1 (Colton blood group)	Homo sapiens	141-146
12242327-0	2002	Can a continuum solvent model reproduce the free energy landscape of a beta -hairpin folding in water?	Water	96-101	amyloid beta precursor protein	Homo sapiens	69-75
12232046-10	2002	These results demonstrate that dystrophin is necessary for polarized distribution of AQP4 protein in brain where facilitated movements of water occur across the blood-brain barrier and cerebrospinal fluid-brain interface.	Water	138-143	dystrophin, muscular dystrophy	Mus musculus	31-41
12462420-2	2002	Using high-density filter-based cDNA microarrays (GeneFilters), we analyzed the expression of over 5000 genes in the dorsal hippocampus of rats treated with 12% ethanol or tap water for 15 months.	Water	176-181	nuclear RNA export factor 1	Rattus norvegicus	172-175
12440435-2	2002	The mission average contributions to the absorbed dose rates (in water) were 126 +/- 4 microGy/d and 121 +/- 13 microGy/d for the GCR and the SAA component, respectively.	Water	65-70	nuclear receptor subfamily 3 group C member 1	Homo sapiens	130-133
12237452-0	2002	Conformational transition states of a beta-hairpin peptide between the ordered and disordered conformations in explicit water.	Water	120-125	amyloid beta precursor protein	Homo sapiens	36-42
12237452-1	2002	The conformational transition states of a beta-hairpin peptide in explicit water were identified from the free energy landscapes obtained from the multicanonical ensemble, using an enhanced conformational sampling calculation.	Water	75-80	amyloid beta precursor protein	Homo sapiens	40-46
12237460-5	2002	In the case of H-FABP, the pH- and temperature-dependent behavior of selected side-chain resonances (Ser82 OgH and the imidazole ring protons of His93) indicated an unusually slow exchange with the solvent, implying that the intricate hydrogen-bonding network of amino-acid side-chains and water molecules in the protein interior is very rigid.	Water	290-295	fatty acid binding protein 3	Homo sapiens	15-21
12224920-1	2002	The equilibrium constant for binding of dimethyl phosphate to a Co(III) complex in water increases from 6.2 to 210 M-1 upon addition of a single hydrogen bond between the bound phosphate and the metal complex.	Water	83-88	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	64-71
12237771-1	2002	Aquaporin 1 is a water channel protein.	Water	17-22	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
12167608-10	2002	Because nNOS is specifically expressed in principal cells of the collecting duct system, the stimulation of nNOS expression by AVP may participate in the control of water reabsorption.	Water	165-170	arginine vasopressin	Rattus norvegicus	127-130
12084722-6	2002	Cross-linking of apoA-I was temperature-dependent, rapid in onset, and detectable with both lipid- and water-soluble cross-linking agents.	Water	103-108	apolipoprotein A1	Homo sapiens	17-23
12080069-0	2002	Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference.	Water	101-106	renin	Homo sapiens	44-49
12223239-0	2002	ZL-DHP lignin model compound at the air-water interface.	Water	40-45	dihydropyrimidinase	Homo sapiens	3-6
12223239-2	2002	ZL-DHP) at the air-water interface.	Water	19-24	dihydropyrimidinase	Homo sapiens	3-6
12202382-0	2002	A model for water motion in crystals of lysozyme based on an incoherent quasielastic neutron-scattering study.	Water	12-17	lysozyme	Homo sapiens	40-48
12234467-0	2002	Direct quantification of human serum albumin in human blood serum without separation of gamma-globulin by the total internal reflected resonance light scattering of thorium-sodium dodecylbenzene sulfonate at water/tetrachloromethane interface.	Water	208-213	albumin	Homo sapiens	31-44
12234467-1	2002	A direct quantification of human serum albumin (HSA) in blood serum samples without separation is proposed based on the measurements of total internal reflected resonance light scattering (TIR-RLS) at water/tetrachloromethane (H(2)O/CCl(4)) interfaces.	Water	201-206	albumin	Homo sapiens	33-46
12202382-1	2002	This paper reports an incoherent quasielastic neutron scattering study of the single particle, diffusive motions of water molecules surrounding a globular protein, the hen egg-white lysozyme.	Water	116-121	lysozyme	Homo sapiens	182-190
12202382-5	2002	The very good agreement between the structural and dynamical studies suggested a model for the dynamics of water in triclinic crystals of lysozyme in the time range approximately 330 ps and at 300 K. Herein, the dynamics of all water molecules is affected by the presence of the protein, and the water molecules can be divided into two populations.	Water	107-112	lysozyme	Homo sapiens	138-146
12202382-5	2002	The very good agreement between the structural and dynamical studies suggested a model for the dynamics of water in triclinic crystals of lysozyme in the time range approximately 330 ps and at 300 K. Herein, the dynamics of all water molecules is affected by the presence of the protein, and the water molecules can be divided into two populations.	Water	228-233	lysozyme	Homo sapiens	138-146
12202382-5	2002	The very good agreement between the structural and dynamical studies suggested a model for the dynamics of water in triclinic crystals of lysozyme in the time range approximately 330 ps and at 300 K. Herein, the dynamics of all water molecules is affected by the presence of the protein, and the water molecules can be divided into two populations.	Water	228-233	lysozyme	Homo sapiens	138-146
12396394-7	2002	The estimated median intake of lead and nitrate per kg body weight from tap water was higher in FF infants than in BF infants or mixed fed (MF) young children.	Water	76-81	USO1 vesicle transport factor	Homo sapiens	72-75
12219173-3	2002	Pretreatment with losartan and [Sar1, Ala8] ANG II completely abolished the water and sodium intake, and the pressor increase (0.5 +/- 0.2, 1.1 +/- 0.2, 0.5 +/- 0.2, and 0.8 +/- 0.2 ml, and 1.2 +/- 3.9, 31 +/- 4.6 mmHg, respectively, N = 9-12), whereas losartan blunted the urinary and sodium excretion induced by ANG II (13.9 +/- 1.0 ml and 187 +/- 10 micro Eq/120 min, respectively, N = 9).	Water	76-81	angiotensinogen	Rattus norvegicus	44-50
12219173-4	2002	Pretreatment with PD 123319 and [Sar1, Ala8] ANG II blocked the urinary and sodium excretion (10.7 +/- 0.8, 9.8 +/- 0.7 ml, and 67 +/- 13 and 57 +/- 17 micro Eq/120 min, respectively, N = 9), whereas pretreatment with PD 123319 partially blocked the water and sodium intake, and the MAP induced by ANG II administration (2.3 +/- 0.3, 1.1 +/- 0.1 ml, and 12 +/- 3 mmHg, respectively, N = 9-10).	Water	250-255	angiotensinogen	Rattus norvegicus	45-51
12171571-4	2002	A homology model of EGFr with PD-153035 suggested that the 3-nitrogen atom of the quinazoline ring binds a water molecule.	Water	107-112	epidermal growth factor receptor	Homo sapiens	20-24
12206439-2	2002	Extraction and concentration of Fenholloway water with C18 solid-phase extraction columns followed by reverse-phase high-pressure liquid chromatography resulted in clearly defined fractions with in vitro androgenic activity in CV-1 cells that had been transiently cotransfected with human androgen receptor and reporter gene constructs.	Water	44-49	androgen receptor	Homo sapiens	289-306
12396394-1	2002	Contaminated tap water can become a health risk, e.g. by metals or environmental pollution particularly for sensitive population groups such as infants and young children.	Water	17-22	USO1 vesicle transport factor	Homo sapiens	13-16
12396394-5	2002	We calculate scenarios for potential tap water contamination.	Water	41-46	USO1 vesicle transport factor	Homo sapiens	37-40
12396394-6	2002	Tap water intake per kg body weight was significantly higher in formula-fed (FF) infants than in breast-fed (BF) infants.	Water	4-9	USO1 vesicle transport factor	Homo sapiens	0-3
12167603-7	2002	We conclude that the urine-concentrating defect in ACE.2 mice is associated with, and may result from, downregulation of some or all of these key urea, salt, and water transport proteins.	Water	162-167	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	51-56
12167605-1	2002	Insulin is an important regulator of renal salt and water excretion, and hyperinsulinemia has been implicated to play a role in hypertension.	Water	52-57	insulin	Homo sapiens	0-7
12202525-10	2002	As in black Swiss outbred mice and other mammalian species, reducing aqueous humor inflow with acetazolamide lowered IOP and administering water intraperitoneally increased IOP in both A3AR-/- and A3AR+/+ mice.	Water	139-144	adenosine A3 receptor	Homo sapiens	197-201
12683421-11	2002	COX-2 inhibition leads to apoptosis of MICs in response to hypertonicity in vitro and following water deprivation in vivo.	Water	96-101	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
12191971-1	2002	Mutations in the Aquaporin-2 gene, which encodes a renal water channel, have been shown to cause autosomal nephrogenic diabetes insipidus (NDI), a disease in which the kidney is unable to concentrate urine in response to vasopressin.	Water	57-62	arginine vasopressin	Homo sapiens	221-232
12192064-0	2002	Structural and dynamic properties of water around acetylcholinesterase.	Water	37-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-70
12172703-0	2002	Transmembrane water influx via aquaporin-1 is inhibited by barbiturates and propofol in red blood cells.	Water	14-19	aquaporin 1 (Colton blood group)	Homo sapiens	31-42
12172703-1	2002	Aquaporin-1 (AQP1) is known to be expressed at a high level in endothelial cell membranes and participates in water transfer into or across these cells.	Water	110-115	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
12172703-1	2002	Aquaporin-1 (AQP1) is known to be expressed at a high level in endothelial cell membranes and participates in water transfer into or across these cells.	Water	110-115	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
12172703-8	2002	Efflux of water (shrinking) was also inhibited by HgCl(2), confirming a significant role of AQP1 in this model.	Water	10-15	aquaporin 1 (Colton blood group)	Homo sapiens	92-96
12213514-3	2002	The water intake caused by ANG II injected into the SFO was significantly enhanced by previous injections of phenylephrine, an alpha-adrenoceptor agonist, but not by isoprenaline, a beta-adrenoceptor agonist.	Water	4-9	angiotensinogen	Rattus norvegicus	27-33
12213514-4	2002	Previous injections of either saralasin, a specific ANG II antagonist, or phentolamine, an alpha-adrenoceptor antagonist, into the MnPO significantly attenuated the water intake caused by the ANG II injection into the SFO.	Water	165-170	angiotensinogen	Rattus norvegicus	192-198
12192064-1	2002	Structural and dynamic properties of water molecules around acetylcholinesterase are examined from a 10-nsec molecular dynamics simulation to help understand how the protein alters water properties.	Water	37-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-80
12192064-1	2002	Structural and dynamic properties of water molecules around acetylcholinesterase are examined from a 10-nsec molecular dynamics simulation to help understand how the protein alters water properties.	Water	181-186	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-80
12176047-1	2002	Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel in the kidney collecting duct.	Water	47-52	arginine vasopressin	Rattus norvegicus	25-36
12916152-10	2002	While applying the thrombin water-saline solution in the conditions selected the preparation has showed itself practically stable during a year without utilizing any admixtures.	Water	28-33	coagulation factor II, thrombin	Homo sapiens	19-27
12211026-10	2002	After the X-ray structure of the modeled proteins became known, the procedure was evaluated for two targets (T47 and the CASP4 target T111) by comparing a long simulation in water with the experimental target structures.	Water	174-179	caspase 4	Homo sapiens	121-126
12110515-0	2002	Water permeability of aquaporin-4 is decreased by protein kinase C and dopamine.	Water	0-5	PKC	Sus scrofa	50-66
12206855-6	2002	These results show that vasopressin plays a significant role in elevating vascular tone through vasopressin V(1A) receptors and plays a major role in retaining free water through vasopressin V(2) receptors in this model of congestive heart failure.	Water	165-170	arginine vasopressin	Rattus norvegicus	24-35
12196951-2	2002	The synthesis of a verdazyl radical with a carboxylate substituent renders the radical highly soluble in water, thereby permitting the aqueous synthesis of Ni(II) and Co(II) verdazyl complexes which have been structurally and magnetically characterized.	Water	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
12110515-10	2002	Reduction of AQP4 water permeability by PDBu and dopamine was abolished by point mutation of Ser(180), a consensus site for PKC phosphorylation.	Water	18-23	PKC	Sus scrofa	124-127
12110515-11	2002	We conclude that PKC and dopamine decrease AQP4 water permeability via phosphorylation at Ser180 and that the effect is likely mediated by gating of the channel.	Water	48-53	PKC	Sus scrofa	17-20
12145051-6	2002	These results suggest that anesthetics reduce the apparent agonist Kd of the nAChR by binding to a site that has a dipolarity and ability to accept hydrogen bonds that are similar to those of water, but a hydrogen bond-donating capacity that is less.	Water	192-197	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	77-82
12163390-2	2002	We provide molecular evidence that guanylin, a bioactive intestinal peptide involved in the CFTR-regulated secretion of electrolyte/water in the gut epithelium, is highly expressed in the human parotid and submandibular glands and in respective clinically most relevant tumors.	Water	132-137	CF transmembrane conductance regulator	Homo sapiens	92-96
12057646-1	2002	A new series of succinate-based dual inhibitors against matrix metalloproteinases (MMPs) and tumor necrosis factor alpha converting enzyme (TACE) possessing highly-water solubility was designed, synthesized, and evaluated for enzyme inhibition.	Water	164-169	ADAM metallopeptidase domain 17	Rattus norvegicus	93-138
12057646-1	2002	A new series of succinate-based dual inhibitors against matrix metalloproteinases (MMPs) and tumor necrosis factor alpha converting enzyme (TACE) possessing highly-water solubility was designed, synthesized, and evaluated for enzyme inhibition.	Water	164-169	ADAM metallopeptidase domain 17	Rattus norvegicus	140-144
12185387-0	2002	Adrenoceptors of the medial septal area modulate water intake and renal excretory function induced by central administration of angiotensin II.	Water	49-54	angiotensinogen	Rattus norvegicus	128-142
12124295-1	2002	We performed an elastic neutron scattering investigation of the molecular dynamics of lysozyme solvated in glycerol, at different water contents h (grams of water/grams of lysozyme).	Water	130-135	lysozyme	Homo sapiens	86-94
12124295-1	2002	We performed an elastic neutron scattering investigation of the molecular dynamics of lysozyme solvated in glycerol, at different water contents h (grams of water/grams of lysozyme).	Water	157-162	lysozyme	Homo sapiens	86-94
12124295-7	2002	This hydration-dependent dynamical activation, which is similar to that of hydrated lysozyme powders, is related to the specific interplay of the protein with the surrounding water and glycerol molecules.	Water	175-180	lysozyme	Homo sapiens	84-92
12185387-4	2002	Clonidine (20 nmol/ micro l) injected into the MSA reduced the ANGII-induced water intake (2.9 +/- 0.5 ml/120 min).	Water	77-82	angiotensinogen	Rattus norvegicus	63-68
12185387-5	2002	Pretreatment with 80 nmol/ micro l yohimbine or prazosin into the MSA also reduced the ANGII-induced water intake (3.0 +/- 0.4 and 3.1 +/- 0.2 ml/120 min, respectively).	Water	101-106	angiotensinogen	Rattus norvegicus	87-92
12185387-6	2002	Yohimbine + prazosin + clonidine injected into the MSA abolished the ANGII-induced water intake (0.2 +/- 0.1 and 0.2 +/- 0.1 ml/120 min, respectively).	Water	83-88	angiotensinogen	Rattus norvegicus	69-74
12185387-3	2002	ANGII (12 nmol/ micro l) increased water intake (12.5 +/- 1.7 ml/120 min).	Water	35-40	angiotensinogen	Rattus norvegicus	0-5
12185387-14	2002	The results showed that MSA injections of alpha1- and alpha2-antagonists decreased ANGII-induced water intake, and abolished the Na+, K+ and urine decrease induced by ANGII into the 3rdV.	Water	97-102	angiotensinogen	Rattus norvegicus	83-88
12185387-15	2002	These findings suggest the involvement of septal alpha1- and alpha2-adrenergic receptors in water intake and electrolyte and urine excretion induced by central ANGII.	Water	92-97	angiotensinogen	Rattus norvegicus	160-165
12211698-3	2002	rats as model animals drinking tap water with and without lead with i.p.	Water	35-40	nuclear RNA export factor 1	Rattus norvegicus	31-34
12126792-2	2002	We have explored the possibility that myeloperoxidase might use H(2)O(2) to convert L-tyrosine to tyrosyl radical.	Water	64-69	myeloperoxidase	Homo sapiens	38-53
12154110-1	2002	Renal endothelin-1 participates in sodium and water handling, and its urinary excretion is increased in sodium-retentive states.	Water	46-51	endothelin 1	Homo sapiens	6-18
12169772-0	2002	Sustained increases in activating transcription factor-2 and activator protein-2 in the rat supraoptic nucleus during water deprivation.	Water	118-123	activating transcription factor 2	Rattus norvegicus	23-80
12169772-6	2002	Increases in AP-2 alpha and ATF-2 were sustained throughout the SON during water deprivation, suggesting that these transcription factors could play a role in the maintenance of VP and oxytocin gene transcription in response to dehydration.	Water	75-80	activating transcription factor 2	Rattus norvegicus	28-33
12127722-2	2002	Following an alteration of the water-lipid interface as a result of, for example, oxidation of lipids, the supramolecular structure becomes destabilized and apoB can misfold.	Water	31-36	apolipoprotein B	Homo sapiens	157-161
12154181-15	2002	The physiological role of EAAT1 for water homeostasis in the central nervous system is discussed.	Water	36-41	solute carrier family 1 member 3	Homo sapiens	26-31
12270686-4	2002	Using cells from transgenic mice that express different levels of SOD1, we found that the level of cellular H(2)O(2), determined by fluorescence activated cell sorting in the presence of an H(2)O(2)-sensitive fluorescent dye, increased in parallel with the level of SOD1 activity.	Water	108-113	superoxide dismutase 1, soluble	Mus musculus	66-70
12270686-4	2002	Using cells from transgenic mice that express different levels of SOD1, we found that the level of cellular H(2)O(2), determined by fluorescence activated cell sorting in the presence of an H(2)O(2)-sensitive fluorescent dye, increased in parallel with the level of SOD1 activity.	Water	108-113	superoxide dismutase 1, soluble	Mus musculus	266-270
12270690-3	2002	Exposure of NT(2) neurons to the two classical pro-oxidant stimuli ascorbate/FeSO(4) and H(2)O(2)/FeSO(4) resulted in a significant generation of HNE, which is temporally followed by an increased production of BACE protein levels.	Water	89-94	beta-secretase 1	Homo sapiens	210-214
12141502-1	2002	Zerovalent iron filings have been proposed as a filter medium for removing As(III) and As(V) compounds from potable water.	Water	116-121	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	87-92
12411029-2	2002	METHODS: In the present study, the effect of IL-1beta and IL-1ra on aromatase (Arom) activity and mRNA expression in human osteoblast-like cells was investigated by [(3)H] water released upon the conversion of [1beta-(3)H] androstenedione to estrone and the reverse-transcription polymerase cain reaction (RT-PCR) method.	Water	172-177	interleukin 1 beta	Homo sapiens	45-53
12113766-0	2002	Mutagenicity of ground water (in the bore-holes) in Ararat Valley (Armenia) detected by Trad-SHM bioassay.	Water	23-28	RAD51 paralog D	Homo sapiens	88-92
12115430-1	2002	The bacterial consortium MPD-M, isolated from sediment associated with Colombian mangrove roots, was effective in the treatment of hydrocarbons in water with salinities varying from 0 to 180 g L(-1).	Water	147-152	mevalonate diphosphate decarboxylase	Homo sapiens	25-28
11983705-5	2002	Here we use modification of reporter cysteines to measure water accessibility at specific residues in TM2 of the type 1 receptor for the octapeptide hormone angiotensin II.	Water	58-63	angiotensinogen	Homo sapiens	157-171
16290748-1	2002	Fourier transform infrared (FTIR) spectroscopy was used to study the conformational changes of the polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) block copolymer, Pluronic P104, in a large concentration range in a polymer-water system as a function of temperature.	Water	247-252	protoporphyrinogen oxidase	Homo sapiens	162-165
16290748-5	2002	The PPO blocks of Pluronic P104 are hydrated only in a condition of lower temperature and higher water content.	Water	97-102	protoporphyrinogen oxidase	Homo sapiens	4-7
12172692-4	2002	One group of rats was chronically exposed to caffeine (1.0 mg/ml) dissolved in their drinking water whereas the other group was exposed to tap water.	Water	143-148	nuclear RNA export factor 1	Rattus norvegicus	139-142
12151754-3	2002	In the kidney collecting duct, vasopressin induces the expression of aquaporin-2 (AQP2), resulting in increased water reabsorption.	Water	112-117	arginine vasopressin	Rattus norvegicus	31-42
12081491-8	2002	Finally, this work emphasizes the essential role of colipase in lipase catalysis at the lipid-water interface in the presence of bile.	Water	94-99	pancreatic lipase	Equus caballus	54-60
12081485-8	2002	The distance of closest approach between the protein moiety of PLAP and the lipid-water interfacial region of the bilayer was estimated to be smaller than 10-14 A.	Water	82-87	alkaline phosphatase, placental	Homo sapiens	63-67
12069945-0	2002	Angiotensin II attenuates the natriuresis of water immersion in humans.	Water	45-50	angiotensinogen	Homo sapiens	0-14
12176006-4	2002	A facile calculation suggests that dermal absorption during showering and hand washing can be an important exposure route if the water contains more than 100 microg/L As(III) or As(V).	Water	129-134	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	178-183
12141822-2	2002	The aim of the present study was to induce HSPs in the pancreas and lungs by thermal (hot-water immersion, HWI) and nonthermal methods (injection of sodium arsenite intraperitoneally) and to investigate the potential effects of HSP preinduction on cholecystokinin-octapeptide (CCK) induced acute pancreatitis and pancreatitis-associated lung injury in rats.	Water	90-95	selenoprotein K	Rattus norvegicus	43-46
12079454-8	2002	In it, there exist mononuclear octahedral sites of Co(II) surrounded by oxygens, belonging to terminal phosphonates and bound water molecules.	Water	126-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
12231480-7	2002	IL-1beta reduced the net absorption of water and chloride.	Water	39-44	interleukin 1 beta	Rattus norvegicus	0-8
12084507-1	2002	Lysozyme-loaded poly(ethylene glycol terephthalate)-poly(butylene terephthalate) (PEGT/PBT) films were prepared using a water-in-oil emulsification solvent evaporation method.	Water	120-125	lysozyme	Homo sapiens	0-8
12081622-4	2002	In this study, the structure of CRAMP in TFE/H2O (1 : 1, v/v) solution was determined by CD and NMR spectroscopy.	Water	45-48	cathelicidin antimicrobial peptide	Homo sapiens	32-37
12115738-6	2002	Cell cultures pre-treated with 50 ng/ml keratinocyte growth factor (KGF) showed a significant delay in oxidant-induced TER decreases caused by 0.1 mM H(2)O(2).	Water	150-155	fibroblast growth factor 7	Homo sapiens	40-66
12115738-6	2002	Cell cultures pre-treated with 50 ng/ml keratinocyte growth factor (KGF) showed a significant delay in oxidant-induced TER decreases caused by 0.1 mM H(2)O(2).	Water	150-155	fibroblast growth factor 7	Homo sapiens	68-71
12115738-10	2002	In contrast, KGF pre-incubation enhanced the recovery of 16HBE cultures exposed for 50 min to 0.5 mM H(2)O(2).	Water	101-106	fibroblast growth factor 7	Homo sapiens	13-16
12081622-5	2002	CD spectra showed that CRAMP adopts a mainly alpha-helical conformation in TFE/H2O solution, DPC micelles, SDS micelles and liposomes, whereas it has a random structure in aqueous solution.	Water	79-82	cathelicidin antimicrobial peptide	Homo sapiens	23-28
12081622-6	2002	The tertiary structure of CRAMP in TFE/H2O (1 : 1, v/v), as determined by NMR spectroscopy, consists of two amphipathic alpha-helices from Leu4 to Lys10 and from Gly16 to Leu33.	Water	39-42	cathelicidin antimicrobial peptide	Homo sapiens	26-31
12432192-5	2002	The aim was to study lipid peroxidation and antioxidant enzymes such as catalase, glutathione peroxidase and superoxide dismutase (SOD) and to correlate the same, with the "water test", in male infertility.	Water	173-178	superoxide dismutase 1	Homo sapiens	131-134
12096044-1	2002	The water permeability of biological membranes has been a longstanding problem in physiology, but the proteins responsible for this remained unknown until discovery of the aquaporin 1 (AQP1) water channel protein.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	172-183
12096044-1	2002	The water permeability of biological membranes has been a longstanding problem in physiology, but the proteins responsible for this remained unknown until discovery of the aquaporin 1 (AQP1) water channel protein.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	185-189
12096044-1	2002	The water permeability of biological membranes has been a longstanding problem in physiology, but the proteins responsible for this remained unknown until discovery of the aquaporin 1 (AQP1) water channel protein.	Water	191-196	aquaporin 1 (Colton blood group)	Homo sapiens	172-183
12096044-1	2002	The water permeability of biological membranes has been a longstanding problem in physiology, but the proteins responsible for this remained unknown until discovery of the aquaporin 1 (AQP1) water channel protein.	Water	191-196	aquaporin 1 (Colton blood group)	Homo sapiens	185-189
12096044-2	2002	AQP1 is selectively permeated by water driven by osmotic gradients.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
12099466-7	2002	Results indicate that neither NO3 nor SO4 was reduced during the course of the aqueous-phase study, suggesting that NO3 and SO4 can behave conservatively in highly reduced water.	Water	172-177	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
12075119-11	2002	Moreover, SP22 may be useful in predicting compromised fertility after exposure to by-products of drinking water disinfection.	Water	107-112	Parkinsonism associated deglycase	Rattus norvegicus	10-14
12044564-10	2002	The insulin diffusion through the water-filled pores would be effectively prevented.	Water	34-39	insulin	Homo sapiens	4-11
12031487-5	2002	Circadian oscillations of m. nocturnin RNA are maintained in mice without the IAP insertion (e.g. CBA/J, 129/sv), are free-running under constant light and dark conditions, and persist upon food and water privation, demonstrating that m. nocturnin is a circadian gene.	Water	199-204	nocturnin	Mus musculus	29-38
12047192-5	2002	Both HThO(OH) and ThO2 add another H2O molecule to give HTh(OH)3 and OTh(OH)2, respectively.	Water	35-38	THO complex 2	Homo sapiens	18-22
12047201-8	2002	Although our computed second-rank dipolar retardations are independent of the water model, SPC/E describes more realistically the time scale of the water dynamics around lysozyme than does TIP3P.	Water	148-153	proline rich protein gene cluster	Homo sapiens	91-94
12031612-0	2002	Adsorption and removal of arsenic(V) from drinking water by aluminum-loaded Shirasu-zeolite.	Water	51-56	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	26-36
11940599-4	2002	Surprisingly, determination of the water/phospholipid interfacial exclusion pressure of the apoA-IV truncation mutants revealed that, for most, deletion of amphipathic alpha-helical domains increased their affinity for phospholipid monolayers.	Water	35-40	apolipoprotein A4	Homo sapiens	92-99
12010754-4	2002	Complete SAD rats ingested more water than control rats when infused with 40, 100, or 250 ng x kg(-1) x min(-1) ANG II.	Water	32-37	angiotensinogen	Rattus norvegicus	112-118
11997316-2	2002	In the kidney collecting duct, these IMP clusters were subsequently identified as possible sites of clathrin-coated pit formation on the plasma membrane, and a clathrin-mediated mechanism for internalization of vasopressin-sensitive water channels was suggested.	Water	233-238	arginine vasopressin	Homo sapiens	211-222
12083551-4	2002	A flow rate of 1.15 ml min(-1) at a column temperature of 43.5 degrees C using 63.7% methanol in water gave the most efficient separation.	Water	97-102	CD59 molecule (CD59 blood group)	Homo sapiens	23-29
12083555-1	2002	Measurements of DSC, NMR and high-frequency spectroscopy have been done on PEO-H2O and PEO-H2O-HQ mixed systems.	Water	79-82	twinkle mtDNA helicase	Homo sapiens	75-78
12193876-17	2002	Water flows into principal cells from collecting duct lumen through AQP2 and flows out to interstitium through AQP3 and AQP4 and finally reachs blood circulation through AQP1 capillaries.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	170-174
12193876-18	2002	Vasopressin orchestrates the live effectors so as to keep water and solutes reabsorptions in balance with volaemia and osmolality set points.	Water	58-63	arginine vasopressin	Homo sapiens	0-11
12083555-4	2002	All the PEO-H2O samples containing H2O show NMR absorption signals, suggesting the existence of movable H2O.	Water	12-15	twinkle mtDNA helicase	Homo sapiens	8-11
12083555-4	2002	All the PEO-H2O samples containing H2O show NMR absorption signals, suggesting the existence of movable H2O.	Water	35-38	twinkle mtDNA helicase	Homo sapiens	8-11
12083555-4	2002	All the PEO-H2O samples containing H2O show NMR absorption signals, suggesting the existence of movable H2O.	Water	35-38	twinkle mtDNA helicase	Homo sapiens	8-11
12083555-1	2002	Measurements of DSC, NMR and high-frequency spectroscopy have been done on PEO-H2O and PEO-H2O-HQ mixed systems.	Water	91-94	twinkle mtDNA helicase	Homo sapiens	87-90
12083555-5	2002	Samples with H2O molar ratio over 0.5, show one absorption peak of H2O protons, and more than two peaks of PEO.	Water	13-16	twinkle mtDNA helicase	Homo sapiens	107-110
12083555-6	2002	The results from DSC and NMR measurements show that the bound state of H2O in PEO, as well as the mobility of PEO itself, varies according to the water content in PEO-H2O samples.	Water	71-74	twinkle mtDNA helicase	Homo sapiens	78-81
12083555-2	2002	DSC measurements show that water molecules contained in PEO are divided roughly into two species: freezable water and non-freezable water.	Water	27-32	twinkle mtDNA helicase	Homo sapiens	56-59
12083555-6	2002	The results from DSC and NMR measurements show that the bound state of H2O in PEO, as well as the mobility of PEO itself, varies according to the water content in PEO-H2O samples.	Water	146-151	twinkle mtDNA helicase	Homo sapiens	78-81
12083555-6	2002	The results from DSC and NMR measurements show that the bound state of H2O in PEO, as well as the mobility of PEO itself, varies according to the water content in PEO-H2O samples.	Water	146-151	twinkle mtDNA helicase	Homo sapiens	110-113
12083555-6	2002	The results from DSC and NMR measurements show that the bound state of H2O in PEO, as well as the mobility of PEO itself, varies according to the water content in PEO-H2O samples.	Water	146-151	twinkle mtDNA helicase	Homo sapiens	110-113
12083555-6	2002	The results from DSC and NMR measurements show that the bound state of H2O in PEO, as well as the mobility of PEO itself, varies according to the water content in PEO-H2O samples.	Water	167-170	twinkle mtDNA helicase	Homo sapiens	78-81
12083555-6	2002	The results from DSC and NMR measurements show that the bound state of H2O in PEO, as well as the mobility of PEO itself, varies according to the water content in PEO-H2O samples.	Water	167-170	twinkle mtDNA helicase	Homo sapiens	110-113
12083555-2	2002	DSC measurements show that water molecules contained in PEO are divided roughly into two species: freezable water and non-freezable water.	Water	108-113	twinkle mtDNA helicase	Homo sapiens	56-59
12083555-2	2002	DSC measurements show that water molecules contained in PEO are divided roughly into two species: freezable water and non-freezable water.	Water	108-113	twinkle mtDNA helicase	Homo sapiens	56-59
12019204-6	2002	Exposure of rats to urea (approximately 225 mg/kg/day) in drinking water for 1 to 3 day(s) resulted in significant increases in CYP2E1 mRNA and protein.	Water	67-72	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	128-134
12083555-6	2002	The results from DSC and NMR measurements show that the bound state of H2O in PEO, as well as the mobility of PEO itself, varies according to the water content in PEO-H2O samples.	Water	167-170	twinkle mtDNA helicase	Homo sapiens	110-113
12083555-7	2002	On the other hand, DSC measurements give the result that PEO-H2O-HQ systems can be considered as homogeneous so long as the content of H2O and/or HQ is not so high.	Water	61-64	twinkle mtDNA helicase	Homo sapiens	57-60
12083555-7	2002	On the other hand, DSC measurements give the result that PEO-H2O-HQ systems can be considered as homogeneous so long as the content of H2O and/or HQ is not so high.	Water	135-138	twinkle mtDNA helicase	Homo sapiens	57-60
12083555-9	2002	Results of high-frequency spectroscopic measurements for the PEO-H2O and PEO-H2O-HQ systems show good agreement with those of DSC and NMR measurements.	Water	65-68	twinkle mtDNA helicase	Homo sapiens	61-64
12083555-9	2002	Results of high-frequency spectroscopic measurements for the PEO-H2O and PEO-H2O-HQ systems show good agreement with those of DSC and NMR measurements.	Water	77-80	twinkle mtDNA helicase	Homo sapiens	73-76
12215219-4	2002	Syk is required for p38 activation following stimulation with 10-100 microM H(2)O(2), but not with 1 mM H(2)O(2).	Water	76-81	mitogen-activated protein kinase 14	Homo sapiens	20-23
12095950-11	2002	An active Pinot Noir red wine SPE C18 column fraction (20% acetonitrile:water) was more effective than complete Pinot Noir wine in suppressing aromatase assay.	Water	72-77	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	143-152
12079272-4	2002	In the exocrine pancreas the CFTR plays a key role in the apical Cl(-), HCO(3)(-), and water transport in duct cells.	Water	87-92	CF transmembrane conductance regulator	Homo sapiens	29-33
12012329-0	2002	Expression of the aquaporin 8 water channel in a rat salivary epithelial cell.	Water	30-35	aquaporin 8	Rattus norvegicus	18-29
12012329-8	2002	Together, these results suggest that SMIE cells endogenously express functional AQP8 water channels.	Water	85-90	aquaporin 8	Rattus norvegicus	80-84
12168505-0	2002	The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the level of brain biogenic monoamines in rats with angiotensin II-induced increase of water intake.	Water	168-173	angiotensinogen	Rattus norvegicus	53-67
12050236-1	2002	Mutations in the aquaporin-2 gene (AQP2), encoding the vasopressin-regulated water channel of the renal collecting duct, are responsible for the autosomal recessive or dominant forms of congenital nephrogenic diabetes insipidus.	Water	77-82	arginine vasopressin	Homo sapiens	55-66
12050236-4	2002	Expression of the G57P and G100V AQP2 proteins in Xenopus oocytes showed only 1.3-fold and 1.2-fold increase, respectively, in the water permeability in contrast to 8.0-fold increase in oocytes injected with wild-type cRNA.	Water	131-136	aquaporin 2 S homeolog	Xenopus laevis	33-37
12168505-0	2002	The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the level of brain biogenic monoamines in rats with angiotensin II-induced increase of water intake.	Water	168-173	angiotensinogen	Rattus norvegicus	133-147
12137754-1	2002	Analysis of osmotic water permeability of aquaporin (AQP) 1, AQP3 and AQP4, which are expressed in human small intestine, in the presence or absence of cholera toxin (CT) was performed using a Xenopus oocyte expression system.	Water	20-25	aquaporin 1 (Colton blood group)	Homo sapiens	42-59
12185990-11	2002	PPAR-gamma is involved in regulating renal hemodynamic and water and sodium transport.	Water	59-64	peroxisome proliferator activated receptor gamma	Homo sapiens	0-10
12044607-8	2002	Our data suggest that tonin may be an alternative pathway to Ang II generation in the brain and could participate in the physiological effects exerted by Ang II such as water and saline intake and blood pressure elevation.	Water	169-174	angiotensinogen	Rattus norvegicus	154-160
12053053-1	2002	The regulation of aquaporin-2 (AQP2) water channel excretion in the collecting duct depends mainly on the action of vasopressin (AVP).	Water	37-42	arginine vasopressin	Homo sapiens	116-127
12545749-6	2002	The simulate test shows that NH4+(-)N could change into NO2-(-)N, while No2-(-)N into NO3-(-)N, which is partly transformed into nitrogen gas by microorganism and majority of which are remained in tap water by form of NO3-(-)N.	Water	201-206	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
12175467-5	2002	In the first experiment in the current study, 60 male Sprague-Dawley rats were trained to drink 10% EtOH in tap water over 3 weeks of limited-access sessions.	Water	112-117	nuclear RNA export factor 1	Rattus norvegicus	108-111
12069916-7	2002	A third sap flow pattern was observed at the end of the dry season after a heavy rainfall event when sap flow became negative in the taproot, and positive in the small roots, indicating movement of water from upper soil layers into shallow roots, and then into taproots and deeper soil layers.	Water	198-203	SH2 domain containing 1A	Homo sapiens	8-11
12069916-7	2002	A third sap flow pattern was observed at the end of the dry season after a heavy rainfall event when sap flow became negative in the taproot, and positive in the small roots, indicating movement of water from upper soil layers into shallow roots, and then into taproots and deeper soil layers.	Water	198-203	SH2 domain containing 1A	Homo sapiens	101-104
11891232-1	2002	Two aquaporin (AQP)-type water channels are expressed in mammalian cornea, AQP1 in endothelial cells and AQP5 in epithelial cells.	Water	25-30	aquaporin 1 (Colton blood group)	Homo sapiens	75-79
12054473-1	2002	We set out to identify whether HOCl, which is generated from H(2)O(2) /MPO/Cl(-), is a proximal mediator of H(2)O(2) programmed cell death in the HL-60 human leukemia cell.	Water	61-66	myeloperoxidase	Homo sapiens	71-74
12009532-3	2002	The amount of water intake induced by the ANG II injection was significantly greater in the PG-treated than in the EB-treated animals.	Water	14-19	angiotensinogen	Rattus norvegicus	42-48
12010029-1	2002	The fluorescence of the water-soluble anionic conjugated polymer, poly[lithium 5-methoxy-2-(4-sulfobutoxy)-1,4-phenylenevinylene] (MBL-PPV), is quenched in dilute aqueous solution by cytochrome c, a small, naturally occurring electron-transfer protein.	Water	24-29	mannose-binding lectin family member 3, pseudogene	Homo sapiens	131-134
12010029-1	2002	The fluorescence of the water-soluble anionic conjugated polymer, poly[lithium 5-methoxy-2-(4-sulfobutoxy)-1,4-phenylenevinylene] (MBL-PPV), is quenched in dilute aqueous solution by cytochrome c, a small, naturally occurring electron-transfer protein.	Water	24-29	cytochrome c, somatic	Homo sapiens	183-195
12076522-12	2002	Because of the low levels of BDCM exposure from drinking water, it appears likely that CYP2E1 will dominate hepatic CYP-mediated BDCM metabolism in humans.	Water	57-62	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	87-93
12076522-12	2002	Because of the low levels of BDCM exposure from drinking water, it appears likely that CYP2E1 will dominate hepatic CYP-mediated BDCM metabolism in humans.	Water	57-62	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	87-90
12027161-4	2002	For the specific cases of a soot particle coated with a water layer and an ice sphere containing an air bubble, the phase-matrix elements -P12/P11 and P33/P11 are unique if the shell is thin.	Water	56-61	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	139-142
12054473-1	2002	We set out to identify whether HOCl, which is generated from H(2)O(2) /MPO/Cl(-), is a proximal mediator of H(2)O(2) programmed cell death in the HL-60 human leukemia cell.	Water	108-113	myeloperoxidase	Homo sapiens	71-74
12011439-7	2002	Hence, in the critical location of distal airways in situ, the Clara cells may play the outstanding role of CFTR-dependent regulation of epithelial electrolyte/water secretion through a sophisticated paracrine/luminocrine mode of guanylin-induced CFTR activation.	Water	160-165	CF transmembrane conductance regulator	Homo sapiens	108-112
11996565-0	2002	Direct observation of the folding and unfolding of a beta-hairpin in explicit water through computer simulation.	Water	78-83	amyloid beta precursor protein	Homo sapiens	51-57
11996565-1	2002	The cooperative folding and unfolding of a beta-hairpin structure are observed in explicit water at native folding conditions through self-guided molecular dynamics simulation.	Water	91-96	amyloid beta precursor protein	Homo sapiens	41-47
11996572-4	2002	These ligands replace Met80 and a water molecule axially coordinated to the heme iron in cytochrome c and MP11, respectively.	Water	34-39	cytochrome c, somatic	Homo sapiens	89-101
16290626-3	2002	The volume of the system increased due to Pb(II) and Cu(II) sorption, suggesting that water molecules hydrated around Pb(II) or Cu(II) ions and AFH were released during sorption.	Water	86-91	submaxillary gland androgen regulated protein 3B	Homo sapiens	42-59
16290626-6	2002	In conclusion, Pb(II) and Cu(II) formed an inner-sphere complex on AFH at pH 4.50, keeping hydrated water on the adsorbed species.	Water	100-105	submaxillary gland androgen regulated protein 3B	Homo sapiens	15-32
11970911-7	2002	Myotubes stimulated with H(2)O(2) exhibited increased I kappa B-alpha phosphorylation and degradation, and treatment of C2C12 with ROS-generating agents increased activator protein (AP)-1 and nuclear factor (NF)-kappa B-dependent promoter activity.	Water	25-30	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	54-69
11880378-2	2002	The water/small solute-transporting protein aquaporin-3 (AQP3) was found by immunofluorescence and immunogold electron microscopy to be expressed at the plasma membrane of epidermal keratinocytes in mouse skin.	Water	4-9	aquaporin 3	Mus musculus	44-55
11880378-2	2002	The water/small solute-transporting protein aquaporin-3 (AQP3) was found by immunofluorescence and immunogold electron microscopy to be expressed at the plasma membrane of epidermal keratinocytes in mouse skin.	Water	4-9	aquaporin 3	Mus musculus	57-61
11880378-5	2002	AQP3 deletion resulted in a &gt; 4-fold reduced osmotic water permeability and &gt; 2-fold reduced glycerol permeability in epidermis.	Water	56-61	aquaporin 3	Mus musculus	0-4
11880378-7	2002	Surface conductance measurements showed remarkably reduced SC water content in AQP3 null mice in the hairless genetic background (165 +/- 10 versus 269 +/- 12 microsiemens (microS), p &lt; 0.001), as well as in a CD1 genetic background (209 +/- 21 versus 469 +/- 11 microS).	Water	62-67	aquaporin 3	Mus musculus	79-83
11880378-10	2002	Conductance measurements after serial tape stripping suggested reduced water content throughout the SC in AQP3 null mice.	Water	71-76	aquaporin 3	Mus musculus	106-110
11880378-11	2002	Water sorption-desorption experiments indicated reduced water holding capacity in the SC of AQP3 null mice.	Water	0-5	aquaporin 3	Mus musculus	92-96
11880378-11	2002	Water sorption-desorption experiments indicated reduced water holding capacity in the SC of AQP3 null mice.	Water	56-61	aquaporin 3	Mus musculus	92-96
12026070-6	2002	In deeper soil horizons, denitrification activity was low (from 0.004 to 0.5 mg N kg(-1) dry soil d(-1)), but contributed significantly to the reduction of ground water NO3- load along the riparian ground water flowpath (from 9.32 to 0.98 mg NO3-N L(-1)).	Water	163-168	NBL1, DAN family BMP antagonist	Homo sapiens	169-172
12016160-6	2002	Catalase and bathocuproine, a Cu(I)-specific chelator, inhibited the DNA damage, suggesting the involvement of H(2)O(2) and Cu(I).	Water	111-116	catalase	Homo sapiens	0-8
12057180-6	2002	RESULTS: Trihalomethane concentrations in the water from Ter were relatively low, with a predominance of chloroform and bromodichloromethane, while concentrations in the water from Llobregat were much higher, with a predominance of bromoform and dibromochloromethane.	Water	46-51	trans-2,3-enoyl-CoA reductase	Homo sapiens	57-60
11961005-8	2002	Both agents, by preventing H(2)O(2) generation, induced human albumin or IgG inhibited NF-kappaB activation.	Water	27-32	nuclear factor kappa B subunit 1	Homo sapiens	87-96
11964222-2	2002	In preliminary tests, P2(1) was shown to yield equivalent results to P1 in simulations of bulk water, a water/vacuum interface, and pure DPPC bilayers with an equal number of lipids per leaflet; equivalence of Pc and P1 was also demonstrated for the former two systems.	Water	95-100	cyclin dependent kinase inhibitor 1A	Homo sapiens	22-27
11964222-2	2002	In preliminary tests, P2(1) was shown to yield equivalent results to P1 in simulations of bulk water, a water/vacuum interface, and pure DPPC bilayers with an equal number of lipids per leaflet; equivalence of Pc and P1 was also demonstrated for the former two systems.	Water	104-109	cyclin dependent kinase inhibitor 1A	Homo sapiens	22-27
11964222-3	2002	P2(1) was further tested in simulations involving the spreading of an octane film on water, and equilibration of a DPPC bilayer from an initial condition containing different numbers of lipids in the two leaflets.	Water	85-90	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-5
11964254-0	2002	Properties of water molecules in the active site gorge of acetylcholinesterase from computer simulation.	Water	14-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-78
11964254-1	2002	A 10-ns trajectory from a molecular dynamics simulation is used to examine the structure and dynamics of water in the active site gorge of acetylcholinesterase to determine what influence water may have on its function.	Water	105-110	acetylcholinesterase (Cartwright blood group)	Homo sapiens	139-159
11964254-1	2002	A 10-ns trajectory from a molecular dynamics simulation is used to examine the structure and dynamics of water in the active site gorge of acetylcholinesterase to determine what influence water may have on its function.	Water	188-193	acetylcholinesterase (Cartwright blood group)	Homo sapiens	139-159
12022502-6	2002	The adjustment of the second water phase to the isoelectric point of the proteins significantly increased the encapsulation yields of catalase, L-asparaginase and BSA.	Water	29-34	catalase	Homo sapiens	134-142
12022502-6	2002	The adjustment of the second water phase to the isoelectric point of the proteins significantly increased the encapsulation yields of catalase, L-asparaginase and BSA.	Water	29-34	asparaginase and isoaspartyl peptidase 1	Homo sapiens	144-158
11987081-6	2002	METHODS: One hundred twenty-eight adult Wistar rats fed orally with standard rat chow and tap water "ad libitum" were maintained in individual metabolic cages for 10 days and divided into 3 groups: control group (n = 71): nonmanipulated animals; RES group (n = 39): 80% gut resection from 10 cm beyond the angle of Treitz to 10 cm above the cecum; RES-PRO group (n = 18): same resection and daily 7.8 x 10(8) CFU B Lactis administration, after orogastric intubation.	Water	94-99	nuclear RNA export factor 1	Rattus norvegicus	90-93
12774323-2	2002	METHOD: HPLC method was used, with Alltech C18 column, acetonitrile-methol-water (43:5:52) as mobile phase with a flow rate of 0.8 mL.min-1, detecting wavelength 280 nm, and column temperature 35 degrees C. RESULT: Retained time of 6-gingerol was near 19 min, showing a good recovery (98.2%) and linear correlation (r = 0.9999).	Water	75-80	CD59 molecule (CD59 blood group)	Homo sapiens	134-139
12153035-0	2002	Water quality control in the river Arno.	Water	0-5	cytohesin 2	Homo sapiens	35-39
12175780-8	2002	However, the activity of 1alpha,25(OH)2-3-epi-D3 when compared to 1alpha,25(OH)2D3 in generating VDR-mediated transcriptional activity in ROS 17/2.8 cells transfected with human osteocalcin VDRE/growth hormone gene construct, was significantly reduced.	Water	34-39	bone gamma-carboxyglutamate protein	Homo sapiens	178-189
12175780-8	2002	However, the activity of 1alpha,25(OH)2-3-epi-D3 when compared to 1alpha,25(OH)2D3 in generating VDR-mediated transcriptional activity in ROS 17/2.8 cells transfected with human osteocalcin VDRE/growth hormone gene construct, was significantly reduced.	Water	34-39	growth hormone 1	Homo sapiens	195-209
11997978-5	2002	Photodegradation of CGA-140,408 and CGA-177,960 was enhanced in humic acid water, paddy water and aqueous acetone solutions, and followed first-order kinetics.	Water	75-80	chromogranin A	Homo sapiens	20-23
11997978-5	2002	Photodegradation of CGA-140,408 and CGA-177,960 was enhanced in humic acid water, paddy water and aqueous acetone solutions, and followed first-order kinetics.	Water	75-80	chromogranin A	Homo sapiens	36-39
11997978-5	2002	Photodegradation of CGA-140,408 and CGA-177,960 was enhanced in humic acid water, paddy water and aqueous acetone solutions, and followed first-order kinetics.	Water	88-93	chromogranin A	Homo sapiens	20-23
11997978-5	2002	Photodegradation of CGA-140,408 and CGA-177,960 was enhanced in humic acid water, paddy water and aqueous acetone solutions, and followed first-order kinetics.	Water	88-93	chromogranin A	Homo sapiens	36-39
12007092-2	2002	Accurate single-crystal diffraction data were measured on a suitable crystal with Mo(K alpha) radiation at 125 K. The CoII ion is coordinated in a square bipyramidal fashion with four imino nitrogen atoms at the equatorial plane and two water molecules at the axial positions.	Water	237-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
18968616-1	2002	A screen-printed biosensor for the detection of pesticides in water miscible organic solvents is described based on the use of p-aminophenyl acetate as acetylcholinesterase substrate.	Water	62-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	152-172
11959992-0	2002	Is the first hydration shell of lysozyme of higher density than bulk water?	Water	69-74	lysozyme	Homo sapiens	32-40
11959992-2	2002	Here, using molecular dynamics simulation, we provide an explanation of recent x-ray and neutron solution scattering data that indicate that the density of water on the surface of lysozyme is significantly higher than that of bulk water.	Water	156-161	lysozyme	Homo sapiens	180-188
11959992-2	2002	Here, using molecular dynamics simulation, we provide an explanation of recent x-ray and neutron solution scattering data that indicate that the density of water on the surface of lysozyme is significantly higher than that of bulk water.	Water	231-236	lysozyme	Homo sapiens	180-188
11922623-6	2002	In both pepsinogen and progastricsin a lysine side-chain in the pro-segment forms a salt bridge to the two catalytic aspartates, occupying the position normally occupied by a catalytic water.	Water	185-190	progastricsin	Homo sapiens	23-36
11993863-3	2002	Using this method, certain fluorochemicals can be quantitatively measured in water samples down to 25 ppt, a level well below calculated drinking water advisory levels.	Water	77-82	tachykinin precursor 1	Homo sapiens	102-105
11974735-5	2002	Two key conclusions could be drawn from the available research: The tap water tested was generally agreed to be safe from harmful bacteria and had no contaminating bacteria; Human and rat models showed a clear benefit in using tap water to cleanse soft tissue wounds, thus concluding tap water is safe for use on wounds (Towler, 2000).	Water	231-236	nuclear RNA export factor 1	Rattus norvegicus	227-230
11917120-0	2002	Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles.	Water	50-55	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
11917120-3	2002	Evidence is presented here that the water channel aquaporin-1 (AQP1) is present in the ZG membrane and participates in rapid GTP-induced vesicular water gating and swelling.	Water	36-41	aquaporin 1 (Colton blood group)	Homo sapiens	63-67
11917120-8	2002	Our results demonstrate that AQP1 associated at the ZG membrane is involved in basal as well as GTP-induced rapid gating of water in ZGs of the exocrine pancreas.	Water	124-129	aquaporin 1 (Colton blood group)	Homo sapiens	29-33
11974735-5	2002	Two key conclusions could be drawn from the available research: The tap water tested was generally agreed to be safe from harmful bacteria and had no contaminating bacteria; Human and rat models showed a clear benefit in using tap water to cleanse soft tissue wounds, thus concluding tap water is safe for use on wounds (Towler, 2000).	Water	231-236	nuclear RNA export factor 1	Rattus norvegicus	227-230
11974735-5	2002	Two key conclusions could be drawn from the available research: The tap water tested was generally agreed to be safe from harmful bacteria and had no contaminating bacteria; Human and rat models showed a clear benefit in using tap water to cleanse soft tissue wounds, thus concluding tap water is safe for use on wounds (Towler, 2000).	Water	231-236	nuclear RNA export factor 1	Rattus norvegicus	227-230
11974735-5	2002	Two key conclusions could be drawn from the available research: The tap water tested was generally agreed to be safe from harmful bacteria and had no contaminating bacteria; Human and rat models showed a clear benefit in using tap water to cleanse soft tissue wounds, thus concluding tap water is safe for use on wounds (Towler, 2000).	Water	231-236	nuclear RNA export factor 1	Rattus norvegicus	227-230
11927381-0	2002	Adaptation to sustained high plasma vasopressin in water and electrolyte homeostasis in the rat transgenic for the metallothionein-vasopressin fusion gene.	Water	51-56	arginine vasopressin	Rattus norvegicus	36-47
12062361-7	2002	CONCLUSIONS: In CHF, blockade of vasopressin V(1a) and V(2) receptors was associated with increased water excretion, and the combination of conivaptan with ACE inhibition was the only treatment to reduce blood pressure, natriuretic peptide and pulmonary congestion.	Water	100-105	arginine vasopressin	Rattus norvegicus	33-44
12186308-5	2002	Tap water was then administered until there were no signs of fecal blood.	Water	4-9	nuclear RNA export factor 1	Rattus norvegicus	0-3
12004939-0	2002	Analysis of CL-20 in environmental matrices: water and soil.	Water	45-50	epithelial membrane protein 1	Homo sapiens	12-17
12004939-2	2002	CL-20 (a new explosives compound) is thermally labile, exhibits high polarity, and has low solubility in water.	Water	105-110	epithelial membrane protein 1	Homo sapiens	0-5
11927381-2	2002	Recently, we have generated rats transgenic for the metallothionein I-human arginine vasopressin (AVP) fusion gene (Tg), which produced high plasma AVP with relatively preserved renal water excretion, suggesting that there might be adaptive mechanism(s) for maintaining water and electrolyte homeostasis against chronic AVP oversecretion from the earliest stage of life.	Water	184-189	metallothionein 1	Rattus norvegicus	52-69
11927381-2	2002	Recently, we have generated rats transgenic for the metallothionein I-human arginine vasopressin (AVP) fusion gene (Tg), which produced high plasma AVP with relatively preserved renal water excretion, suggesting that there might be adaptive mechanism(s) for maintaining water and electrolyte homeostasis against chronic AVP oversecretion from the earliest stage of life.	Water	184-189	arginine vasopressin	Homo sapiens	98-101
11927381-3	2002	In this study, to investigate whether down-regulation of AVP V2 receptor (V2R), which could possibly be caused by long-standing high plasma AVP, participates in this adaptive mechanism(s), non-peptidic V2R antagonist OPC31260 was administered to reverse the down-regulation, and water loading was performed after V2R antagonist treatment had been withdrawn.	Water	279-284	arginine vasopressin receptor 2	Rattus norvegicus	57-77
11927381-3	2002	In this study, to investigate whether down-regulation of AVP V2 receptor (V2R), which could possibly be caused by long-standing high plasma AVP, participates in this adaptive mechanism(s), non-peptidic V2R antagonist OPC31260 was administered to reverse the down-regulation, and water loading was performed after V2R antagonist treatment had been withdrawn.	Water	279-284	arginine vasopressin	Rattus norvegicus	57-60
11927381-3	2002	In this study, to investigate whether down-regulation of AVP V2 receptor (V2R), which could possibly be caused by long-standing high plasma AVP, participates in this adaptive mechanism(s), non-peptidic V2R antagonist OPC31260 was administered to reverse the down-regulation, and water loading was performed after V2R antagonist treatment had been withdrawn.	Water	279-284	arginine vasopressin receptor 2	Rattus norvegicus	74-77
11927381-9	2002	These results suggest that long-standing high plasma AVP causes V2R down-regulation, and it may play an important role in the adaptive mechanism(s) for maintaining water and electrolyte homeostasis in chronically AVP-overexpressing rats.	Water	164-169	arginine vasopressin	Homo sapiens	53-56
11923418-2	2002	The protein Big Brain (BIB) has sequence identity with the major intrinsic protein family that includes the water- and ion-conducting aquaporin channels.	Water	108-113	big brain	Drosophila melanogaster	12-21
11923418-2	2002	The protein Big Brain (BIB) has sequence identity with the major intrinsic protein family that includes the water- and ion-conducting aquaporin channels.	Water	108-113	big brain	Drosophila melanogaster	23-26
12037614-1	2002	The spatial distribution of interstitial NO2(-) concentrations was studied in NO3(-)-exposed freshwater sediment microcosms, using pore water extractions as well as ion-selective microsensors.	Water	98-103	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
12037614-4	2002	Two modes of NO3(-) supply to the sediments were compared: In treatments with NO3(-) supply to the overlying water, a subsurface maximum of NO2(-) concentration was observed, coinciding with the site of maximum NO3(-) consumption.	Water	109-114	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
11981532-5	2002	Having identified several food allergies this "clinical ecologist" had placed the child on a spartan diet of bread, water and salt, and had reduced his insulin dosage by 68%.	Water	116-121	insulin	Homo sapiens	152-159
12037614-4	2002	Two modes of NO3(-) supply to the sediments were compared: In treatments with NO3(-) supply to the overlying water, a subsurface maximum of NO2(-) concentration was observed, coinciding with the site of maximum NO3(-) consumption.	Water	109-114	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
11856832-7	2002	Flash-cooled triclinic crystals of lysozyme, which have a smaller water content than the tetragonal form, diffract to higher resolution with smaller mosaicities and exhibit pronounced ordered domain structure even before annealing.	Water	66-71	lysozyme	Homo sapiens	35-43
11943215-1	2002	Nuclear magnetic resonance (NMR) spectroscopy reveals that higher-order aggregates of glucagon-like peptide-1-(7-36)-amide (GLP-1) in pure water at pH 2.5 are disrupted by 35% 2,2,2-trifluoroethanol (TFE), and form a stable and highly symmetric helical self-aggregate.	Water	139-144	glucagon	Homo sapiens	86-109
11872267-0	2002	Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid beta peptide and interleukin-1beta.	Water	0-5	amyloid beta precursor protein	Homo sapiens	116-128
11872267-0	2002	Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid beta peptide and interleukin-1beta.	Water	0-5	interleukin 1 beta	Homo sapiens	141-158
18968550-8	2002	Lead has been determined in river (RSD approximately 2.6-12.8%) and tap (RSD approximately 1.8-7.2%) water samples.	Water	101-106	SEC14 like lipid binding 2	Homo sapiens	68-71
12044078-0	2002	Kinetics of adsorption of Co(II) removal from water and wastewater by ion exchange resins.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
11891305-2	2002	Catalase, which is involved in the degradation of H(2)O(2) into water and oxygen, is the major H(2)O(2)-scavenging enzyme in all aerobic organisms.	Water	64-69	catalase	Homo sapiens	0-8
11958956-0	2002	The nitrone spin trap PBN alters the cellular response to H(2)O(2): activation of the EGF receptor/ERK pathway.	Water	58-63	Eph receptor B1	Rattus norvegicus	99-102
11879013-5	2002	The enzymatically generated water-soluble dextrins (maltose and DP3, DP4, DP5, and DP6 dextrins) are the most effective in preserving crumb softness during bread storage.	Water	28-33	transcription factor Dp family member 3	Homo sapiens	69-72
11909609-3	2002	In the rat inner medullary collecting duct basolateral, but not apical, ATP (0.1-100 microM) reversibly inhibited vasopressin-induced increases in water permeability with an IC50 of 1.09 microM.	Water	147-152	arginine vasopressin	Rattus norvegicus	114-125
12002613-0	2002	Localization and expression of the aquaporin-1 water channel in mesangial cells in the human glomerulus.	Water	47-52	aquaporin 1 (Colton blood group)	Homo sapiens	35-46
11814851-2	2002	Conjugates of cellobiosyl ceramide and melibiosyl ceramide were synthetically prepared as water-soluble GSL analogues.	Water	90-95	cathepsin A	Homo sapiens	104-107
11832388-4	2002	The angiotensin type 1 (AT1) ANG II receptor subtype antagonist SKF-108566, also given intracerebroventricularly, caused a significant reduction in water consumption in lactating rats, whereas it did not significantly affect water intake in control rats.	Water	148-153	angiotensinogen	Rattus norvegicus	29-35
11935193-7	2002	RAMEB, which was slowly metabolized by soil microorganisms, enhanced the presence of PCBs and PCB-cometabolizing bacteria in the soil-water phase, suggesting that RAMEB enhances aerobic biodegradation of PCBs by increasing pollutant bioavailability in soil microcosms.	Water	134-139	pyruvate carboxylase	Homo sapiens	85-88
12002613-1	2002	The expression and localization of the aquaporin-1 (AQP1) water channel were examined in the glomeruli of the human kidney.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	39-50
12002613-1	2002	The expression and localization of the aquaporin-1 (AQP1) water channel were examined in the glomeruli of the human kidney.	Water	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	52-56
12002613-9	2002	This study showed the distinct localization of AQP1 in the mesangial cells of human glomeruli, suggesting its role in water movement through these cells.	Water	118-123	aquaporin 1 (Colton blood group)	Homo sapiens	47-51
12048813-2	2002	The results showed that 1.33 x 10(3) Pa CS2 could act with O2 or H2O in the atmosphere (25 degrees C, 10(5) Pa) under electric discharge conditions (V = 3000 V), and COS was produced as well as other species such as CO, CO2, SO2 and so on.	Water	65-68	chorionic somatomammotropin hormone 2	Homo sapiens	40-43
11867476-1	2002	We determined the stability diagram of a modified cytochrome c protein in a glycerol water mixture by measuring the first and the second moment of the fluorescence from the chromophore as a function of temperature and pressure.	Water	85-90	cytochrome c, somatic	Homo sapiens	50-62
11895881-9	2002	Addition of corticosterone in the drinking water restored plasma hormone level and markedly decreased TPA-induced ERK activity in Adx mice (P &lt; 0.05).	Water	43-48	mitogen-activated protein kinase 1	Mus musculus	114-117
11861298-5	2002	MPO-dependent use of a low-molecular-weight substrate(s) in plasma for initiating lipid peroxidation was illustrated by demonstrating that the filtrate of plasma (10-kd MWt cutoff) could supply components required for low-density lipoprotein lipid peroxidation in the presence of MPO and H(2)O(2).	Water	288-293	myeloperoxidase	Homo sapiens	0-3
11949851-8	2002	Milk fat and protein percentages declined with glucose infusion because of increased lactose synthesis and secretion of water into milk.	Water	120-125	Weaning weight-maternal milk	Bos taurus	0-4
11949851-8	2002	Milk fat and protein percentages declined with glucose infusion because of increased lactose synthesis and secretion of water into milk.	Water	120-125	Weaning weight-maternal milk	Bos taurus	131-135
11841202-8	2002	We estimate that amide-related H bonds (amide-carbonyl and amide-water) contribute favorably to protein stability by approximately 30-50 kcal/mol in lambda repressor, GCN4 coiled coil, and cytochrome c but unfavorably by approximately 6 kcal/mol in ubiquitin.	Water	65-70	cytochrome c, somatic	Homo sapiens	189-201
11914752-3	2002	We present the development of a liquid formula that can be easily dispersed in water to produce particles named "nanocubicles" which efficiently encapsulate insulin.	Water	79-84	insulin	Homo sapiens	157-164
11861807-8	2002	A water-soluble analog of arvanil, O-2142, was as active on VR1, much less active on AMT and CB1, and more potent on FAAH.	Water	2-7	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	60-63
11897270-1	2002	Lean, preweanling Zucker rat pups increase neuropeptide Y (NPY) expression in the hypothalamic arcuate nucleus in response to a 24-h deprivation of food, water, and maternal interaction as early as postnatal day 2 (P2).	Water	154-159	neuropeptide Y	Rattus norvegicus	43-57
11897270-1	2002	Lean, preweanling Zucker rat pups increase neuropeptide Y (NPY) expression in the hypothalamic arcuate nucleus in response to a 24-h deprivation of food, water, and maternal interaction as early as postnatal day 2 (P2).	Water	154-159	neuropeptide Y	Rattus norvegicus	59-62
11932487-1	2002	In a previous report we have shown that the endothelin-B receptor-selective linear endothelin peptide, ET-1[Cys (Acm)1,15, Ala3, Leu7, Aib11], folds into an alpha-helical conformation in a methanol-d3/water co-solvent [Hewage et al.	Water	201-206	endothelin receptor type B	Homo sapiens	44-65
11932487-1	2002	In a previous report we have shown that the endothelin-B receptor-selective linear endothelin peptide, ET-1[Cys (Acm)1,15, Ala3, Leu7, Aib11], folds into an alpha-helical conformation in a methanol-d3/water co-solvent [Hewage et al.	Water	201-206	endothelin 1	Homo sapiens	103-111
11932487-1	2002	In a previous report we have shown that the endothelin-B receptor-selective linear endothelin peptide, ET-1[Cys (Acm)1,15, Ala3, Leu7, Aib11], folds into an alpha-helical conformation in a methanol-d3/water co-solvent [Hewage et al.	Water	201-206	beta-1,3-glucuronyltransferase 1	Homo sapiens	129-133
11978418-5	2002	Fibrinolysis with tissue plasminogen activator (t-PA) was measured by solubilization of radiolabeled fibrin exposed to a calibrated US field in a temperature-controlled water bath.	Water	169-174	plasminogen activator, tissue type	Homo sapiens	18-52
11851394-7	2002	In this modified CAV variant, C131-MI acts as a proton shuttle, facilitating the deprotonation of a zinc-bound water molecule to regenerate the nucleophilic zinc-bound hydroxide ion.	Water	111-116	carbonic anhydrase 5a, mitochondrial	Mus musculus	17-20
12027219-9	2002	The failure of dopamine to downregulate NHE-3 may cause hypertension through renal salt and water retention.	Water	92-97	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	40-45
11860370-0	2002	Atrial distension, haemodilution, and acute control of renin release during water immersion in humans.	Water	76-81	renin	Homo sapiens	55-60
11821009-4	2002	The biological relevance of this model was checked with respect on the one hand, to the close relationship between the log of drug permeability coefficient normalized to molecular weight and the log of the 1-octanol/water partition coefficient, and on the other hand to the functional P-glycoprotein (P-gp) expression.	Water	216-221	ATP binding cassette subfamily B member 1	Homo sapiens	285-299
11821009-4	2002	The biological relevance of this model was checked with respect on the one hand, to the close relationship between the log of drug permeability coefficient normalized to molecular weight and the log of the 1-octanol/water partition coefficient, and on the other hand to the functional P-glycoprotein (P-gp) expression.	Water	216-221	ATP binding cassette subfamily B member 1	Homo sapiens	301-305
11831889-3	2002	The prevailing CCK-15 conformer in a mixture 1,1,1,3,3,3-hexafluoroacetone/water reveals that the residues common to CCK-15 and CCK-8 assume very similar conformations.	Water	75-80	cholecystokinin	Homo sapiens	15-18
11831889-3	2002	The prevailing CCK-15 conformer in a mixture 1,1,1,3,3,3-hexafluoroacetone/water reveals that the residues common to CCK-15 and CCK-8 assume very similar conformations.	Water	75-80	cholecystokinin	Homo sapiens	117-120
11831889-3	2002	The prevailing CCK-15 conformer in a mixture 1,1,1,3,3,3-hexafluoroacetone/water reveals that the residues common to CCK-15 and CCK-8 assume very similar conformations.	Water	75-80	cholecystokinin	Homo sapiens	117-120
11807248-4	2002	In test calculations, excellent agreement with experiment is found between neutron and X-ray scattering profiles calculated from a molecular-dynamics simulation of lysozyme in water.	Water	176-181	lysozyme	Homo sapiens	164-172
11792654-9	2002	Coadministration of losartan prevented the effect of ANG II on body weight, food intake, blood pressure, and water intake.	Water	109-114	angiotensinogen	Rattus norvegicus	53-59
11788445-5	2002	Moreover, vasopressin-mediated renal water reabsorption, as evaluated by the aquaretic response to selective V(2)-receptor blockade, was significantly increased.	Water	37-42	arginine vasopressin	Rattus norvegicus	10-21
11788448-1	2002	Renal regulation of mammalian water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which is expressed in the apical and basolateral membranes of proximal tubules and descending limbs of Henle, and aquaporin-2 (AQP2), which is redistributed from intracellular vesicles to the apical membrane (AM) of collecting duct cells with vasopressin.	Water	30-35	aquaporin 1 (Colton blood group)	Homo sapiens	67-78
11788448-1	2002	Renal regulation of mammalian water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which is expressed in the apical and basolateral membranes of proximal tubules and descending limbs of Henle, and aquaporin-2 (AQP2), which is redistributed from intracellular vesicles to the apical membrane (AM) of collecting duct cells with vasopressin.	Water	30-35	aquaporin 1 (Colton blood group)	Homo sapiens	80-84
11788448-1	2002	Renal regulation of mammalian water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which is expressed in the apical and basolateral membranes of proximal tubules and descending limbs of Henle, and aquaporin-2 (AQP2), which is redistributed from intracellular vesicles to the apical membrane (AM) of collecting duct cells with vasopressin.	Water	30-35	arginine vasopressin	Homo sapiens	344-355
11788448-1	2002	Renal regulation of mammalian water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which is expressed in the apical and basolateral membranes of proximal tubules and descending limbs of Henle, and aquaporin-2 (AQP2), which is redistributed from intracellular vesicles to the apical membrane (AM) of collecting duct cells with vasopressin.	Water	86-91	aquaporin 1 (Colton blood group)	Homo sapiens	67-78
11788448-1	2002	Renal regulation of mammalian water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which is expressed in the apical and basolateral membranes of proximal tubules and descending limbs of Henle, and aquaporin-2 (AQP2), which is redistributed from intracellular vesicles to the apical membrane (AM) of collecting duct cells with vasopressin.	Water	86-91	aquaporin 1 (Colton blood group)	Homo sapiens	80-84
11792666-8	2002	The changes in Fos expression and PRA are consistent with a proposed role for ANG II in the control of the sodium appetite produced by water deprivation followed by rehydration with only water.	Water	135-140	angiotensinogen	Rattus norvegicus	78-84
11792666-8	2002	The changes in Fos expression and PRA are consistent with a proposed role for ANG II in the control of the sodium appetite produced by water deprivation followed by rehydration with only water.	Water	187-192	angiotensinogen	Rattus norvegicus	78-84
11788448-1	2002	Renal regulation of mammalian water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which is expressed in the apical and basolateral membranes of proximal tubules and descending limbs of Henle, and aquaporin-2 (AQP2), which is redistributed from intracellular vesicles to the apical membrane (AM) of collecting duct cells with vasopressin.	Water	86-91	arginine vasopressin	Homo sapiens	344-355
11849667-5	2002	PON activity correlated negatively (r=-0.31 to -0.37) with intake of vegetables, total and water-soluble fiber, as well as intake of beta-carotene.	Water	91-96	paraoxonase 1	Homo sapiens	0-3
11858846-7	2002	Differences in the structures of BK and T-kinin in water may explain their susceptibility/resistance to the action of ACE.	Water	51-56	angiotensin I converting enzyme	Homo sapiens	118-121
11799146-1	2002	Angiotensin II (Ang II) regulates water and sodium transport in renal tubules and gastrointestinal tract.	Water	34-39	angiotensinogen	Homo sapiens	0-14
11933560-3	2002	It is through the intermediary of the renal V2 receptor, controlling the reabsorption of water by the collecting duct, that vasopressin finely regulates the blood osmolarity.	Water	89-94	arginine vasopressin	Homo sapiens	124-135
11805186-11	2002	These findings suggest a role for Ang1 in the maintenance of the glomerular endothelium and make it a good candidate to be a regulator of the actions of VEGF on glomerular permeability, resisting angiogenesis while allowing the induction of high permeability to water and small solutes.	Water	262-267	vascular endothelial growth factor A	Homo sapiens	153-157
11799146-1	2002	Angiotensin II (Ang II) regulates water and sodium transport in renal tubules and gastrointestinal tract.	Water	34-39	angiotensinogen	Homo sapiens	16-22
12503612-10	2002	The crystal structure of PDE4 contains magnesium and zinc cations as well as catalytic water molecule but no ligand.	Water	87-92	phosphodiesterase 4A	Homo sapiens	25-29
11826172-1	2002	Arginine vasopressin (AVP) regulates the osmotic water permeability of the kidney collecting duct by inducing exocytotic insertion of aquaporin-2 into apical membrane.	Water	49-54	arginine vasopressin	Rattus norvegicus	9-20
11826172-1	2002	Arginine vasopressin (AVP) regulates the osmotic water permeability of the kidney collecting duct by inducing exocytotic insertion of aquaporin-2 into apical membrane.	Water	49-54	arginine vasopressin	Rattus norvegicus	22-25
11826172-11	2002	Pre-incubating the IMCD with an intracellular Ca2+ chelator, BAPTA, prevented AVP-induced intracellular Ca2+ mobilization, apical exocytosis, and increase of osmotic water permeability.	Water	166-171	arginine vasopressin	Rattus norvegicus	78-81
11981980-4	2002	This was attributed to changes in atmospheric concentrations and water temperature, based on measurements showing the PCB levels in the atmosphere and surface water to be close to a partitioning equilibrium.	Water	65-70	pyruvate carboxylase	Homo sapiens	118-121
11825606-10	2002	It is proposed that these residues serve to deliver the catalytic water molecule required for hydrolysis of the cysteine-bound XMP* intermediate formed after oxidation by NAD.	Water	66-71	epithelial membrane protein 2	Homo sapiens	127-131
11707436-7	2002	In vitro, recombinant Hex S was highly active on water-soluble and amphiphilic glycoconjugates including artificial substrates, sulfated GAG fragments, and the sulfated glycosphingolipid SM2.	Water	49-54	hematopoietically expressed homeobox	Mus musculus	22-25
11858955-3	2002	After the treatment of keratinocytes with 300 microM H(2)O(2), a translocation of NF-kappaB from the cytoplasm to nucleus was observed in an immunofluorescence study using anti-human NF-kappaB1 and anti-human RelA antibodies.	Water	53-58	nuclear factor kappa B subunit 1	Homo sapiens	82-91
11802719-3	2002	ckshs1 and ckshs2 both have marginal thermodynamic stability (the free energies of unfolding at 25 degrees C are 3.0 and 2.5 kcal/mol, respectively) and low kinetic stability (the rates of unfolding in water are approximately 1 s(-1)).	Water	202-207	CDC28 protein kinase regulatory subunit 2	Homo sapiens	11-17
11723127-8	2002	Consistent with these in vitro observations, exposure of mice to arsenic in drinking water, which has been found previously to be associated with AP-1 activation and epithelial proliferation, induces EGFR and ERK activation in the urinary bladder.	Water	85-90	mitogen-activated protein kinase 1	Mus musculus	209-212
11810712-1	2002	Magnocellular neuroendocrine cells (MNCs) of the supraoptic nucleus of the hypothalamus (SON) produce and release the hormones vasopressin (VP) and oxytocin (OT) in response to a variety of stimuli to regulate body water and salt, parturition and lactation.	Water	215-220	arginine vasopressin	Homo sapiens	127-138
11831764-8	2002	Although water release was not found to be a major contributor to endothermic adsorption heats, it is likely to be a contributor to the entropic driving force associated with the adsorption of bovine serum albumin.	Water	9-14	albumin	Homo sapiens	200-213
11811423-8	2002	EDA-imprinted sol-gels, deposited as films on glass microscope slides, were shown to quantitatively detect DDT in water to a limit-of-detection of 50 ppt with a response time of &lt;60 s. Repeat measurements could be made with the same sensing films after rinsing with acetone between each measurement.	Water	114-119	D-dopachrome tautomerase	Homo sapiens	107-110
11841805-0	2002	Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury.	Water	36-41	poly(ADP-ribose) polymerase 1	Homo sapiens	87-115
11810712-1	2002	Magnocellular neuroendocrine cells (MNCs) of the supraoptic nucleus of the hypothalamus (SON) produce and release the hormones vasopressin (VP) and oxytocin (OT) in response to a variety of stimuli to regulate body water and salt, parturition and lactation.	Water	215-220	arginine vasopressin	Homo sapiens	140-142
12325458-1	2002	Deep sea water intake improves skin symptoms and mineral imbalance and decreases serum IgE levels mad IgE-inducing cytokines, IL-4, IL-13 and IL-18 in patients with atopic eczema/dermatitis syndrome (AEDS), while distilled water intake fails to do so.	Water	9-14	immunoglobulin heavy constant epsilon	Homo sapiens	87-90
12362990-1	2002	Glycophorin A (GPA), the major sialoglycoprotein of the human erythrocyte membrane, was isolated from erythrocytes of healthy individuals of blood groups A, B and O using phenol-water extraction of erythrocyte membranes.	Water	178-183	glycophorin A (MNS blood group)	Homo sapiens	0-19
12325458-1	2002	Deep sea water intake improves skin symptoms and mineral imbalance and decreases serum IgE levels mad IgE-inducing cytokines, IL-4, IL-13 and IL-18 in patients with atopic eczema/dermatitis syndrome (AEDS), while distilled water intake fails to do so.	Water	9-14	immunoglobulin heavy constant epsilon	Homo sapiens	102-105
12325458-1	2002	Deep sea water intake improves skin symptoms and mineral imbalance and decreases serum IgE levels mad IgE-inducing cytokines, IL-4, IL-13 and IL-18 in patients with atopic eczema/dermatitis syndrome (AEDS), while distilled water intake fails to do so.	Water	9-14	interleukin 4	Homo sapiens	126-130
12325458-1	2002	Deep sea water intake improves skin symptoms and mineral imbalance and decreases serum IgE levels mad IgE-inducing cytokines, IL-4, IL-13 and IL-18 in patients with atopic eczema/dermatitis syndrome (AEDS), while distilled water intake fails to do so.	Water	9-14	interleukin 13	Homo sapiens	132-137
12371620-4	2002	Th1 producing IFN-gamma induce EAU development, while Th2 producing IL-4/IL-10 prevent the disease.	Water	31-34	interferon gamma	Homo sapiens	14-23
11978139-10	2002	Sun protection factor (SPF) is affected by application density, water resistance and other factors.	Water	64-69	SEC14 like lipid binding 2	Homo sapiens	23-26
12440694-2	2002	More recently, this dogma was challenged by the suggestion that secondary active transporters such as the Na/glucose cotransporter (SGLT1) could perform secondary active water transport with a fixed stoichiometry.	Water	170-175	solute carrier family 5 member 1	Homo sapiens	132-137
12440694-3	2002	In the case of SGLT1, the stoichiometry would consist of one glucose molecule to two Na+ ions to 220-400 water molecules.	Water	105-110	solute carrier family 5 member 1	Homo sapiens	15-20
11751290-1	2002	The redox-driven proton pump cytochrome c oxidase is that enzymatic machinery of the respiratory chain that transfers electrons from cytochrome c to molecular oxygen and thereby splits molecular oxygen to form water.	Water	210-215	cytochrome c, somatic	Homo sapiens	29-41
11751290-1	2002	The redox-driven proton pump cytochrome c oxidase is that enzymatic machinery of the respiratory chain that transfers electrons from cytochrome c to molecular oxygen and thereby splits molecular oxygen to form water.	Water	210-215	cytochrome c, somatic	Homo sapiens	133-145
11914159-0	2002	Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle"s loop and a kidney-derived cell line.	Water	28-33	aquaporin 1 (Colton blood group)	Homo sapiens	42-53
11914159-1	2002	BACKGROUND: Aquaporin-1 (AQP1) channels are constitutively active water channels that allow rapid transmembrane osmotic water flux, and also serve as cyclic-GMP-gated ion channels.	Water	66-71	aquaporin 1 (Colton blood group)	Homo sapiens	12-23
11914159-1	2002	BACKGROUND: Aquaporin-1 (AQP1) channels are constitutively active water channels that allow rapid transmembrane osmotic water flux, and also serve as cyclic-GMP-gated ion channels.	Water	66-71	aquaporin 1 (Colton blood group)	Homo sapiens	25-29
11914159-1	2002	BACKGROUND: Aquaporin-1 (AQP1) channels are constitutively active water channels that allow rapid transmembrane osmotic water flux, and also serve as cyclic-GMP-gated ion channels.	Water	120-125	aquaporin 1 (Colton blood group)	Homo sapiens	12-23
11914159-1	2002	BACKGROUND: Aquaporin-1 (AQP1) channels are constitutively active water channels that allow rapid transmembrane osmotic water flux, and also serve as cyclic-GMP-gated ion channels.	Water	120-125	aquaporin 1 (Colton blood group)	Homo sapiens	25-29
11914159-2	2002	Tetraethylammonium chloride (TEA; 0.05 to 10 mM) was shown previously to inhibit the osmotic water permeability of human AQP1 channels expressed in Xenopus oocytes.	Water	93-98	aquaporin 1 (Colton blood group)	Homo sapiens	121-125
11914159-5	2002	RESULTS: TEA blocked water permeability of AQP1 channels in kidney and kidney-derived cells, demonstrating this effect is not limited to the oocyte expression system.	Water	21-26	aquaporin 1 (Colton blood group)	Homo sapiens	43-47
11914159-8	2002	CONCLUSIONS: TEA selectively inhibits osmotic water permeability through native and heterologously expressed AQP1 channels.	Water	46-51	aquaporin 1 (Colton blood group)	Homo sapiens	109-113
11914159-9	2002	The pathways for water and ions in AQP1 differ in pharmacological sensitivity to TEA, and are consistent with the idea of independent solute pathways within the channel structure.	Water	17-22	aquaporin 1 (Colton blood group)	Homo sapiens	35-39
11740968-11	2002	The mechanism of slow NaF release may be the formation of a hydrophobic polysiloxane layer on the surface of NaF powder and resulting slow water diffusion to NaF powder.	Water	139-144	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
11762843-3	2002	The purpose of this study was to delineate the effects of microclimate pH and polymer water content on the stability of encapsulated bovine serum albumin (BSA) by comparing the effects of Mg(OH)2 with those of another excipient, sucrose, which increases polymer water content without significantly affecting acid-base chemistry of the polymer.	Water	86-91	albumin	Homo sapiens	140-153
12421578-0	2002	Giant vacuoles arising during ADH-induced transcellular bulk water flow across the epithelium of the frog urinary bladder.	Water	61-66	arginine vasopressin	Homo sapiens	30-33
12421578-1	2002	Structural changes of the cytoplasm of urinary bladder granular cells after an antidiuretic hormone (ADH) stimulation of water transport were studied using standard and cryogenic methods of electron microscopy.	Water	121-126	arginine vasopressin	Homo sapiens	101-104
12036386-1	2002	The renin-angiotensin system exerts a cardinal role in the maintenance of blood pressure and in the regulation of water and sodium excretion through its multiple effects on the vasculature, the kidneys, the heart, the adrenal glands and the brain.	Water	114-119	renin	Homo sapiens	4-9
12036388-1	2002	The octapeptide angiotensin II (Ang II), the potent effector molecule of the renin-angiotensin-aldosterone system (RAAS), is involved in the control of blood pressure, cardiac and vascular function as well as sodium and water homeostasis.	Water	220-225	angiotensinogen	Homo sapiens	16-30
12036388-1	2002	The octapeptide angiotensin II (Ang II), the potent effector molecule of the renin-angiotensin-aldosterone system (RAAS), is involved in the control of blood pressure, cardiac and vascular function as well as sodium and water homeostasis.	Water	220-225	angiotensinogen	Homo sapiens	32-38
12036388-1	2002	The octapeptide angiotensin II (Ang II), the potent effector molecule of the renin-angiotensin-aldosterone system (RAAS), is involved in the control of blood pressure, cardiac and vascular function as well as sodium and water homeostasis.	Water	220-225	renin	Homo sapiens	77-82
11849298-0	2002	Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake.	Water	153-158	hypocretin neuropeptide precursor	Rattus norvegicus	0-6
11849298-0	2002	Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake.	Water	153-158	hypocretin neuropeptide precursor	Rattus norvegicus	106-112
11849298-1	2002	The neuropeptides orexin-A and orexin-B are produced in neurons of the lateral hypothalamic area and have been implicated to be involved in the regulation of food/water intake and sleep-wake control.	Water	163-168	hypocretin neuropeptide precursor	Rattus norvegicus	18-26
11849298-1	2002	The neuropeptides orexin-A and orexin-B are produced in neurons of the lateral hypothalamic area and have been implicated to be involved in the regulation of food/water intake and sleep-wake control.	Water	163-168	hypocretin neuropeptide precursor	Rattus norvegicus	18-24
12484230-0	2002	Colonic luminal contents (faecal water) induce COX-2.	Water	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
12097826-6	2002	Mice lacking AQP3 are markedly polyuric due to low water permeability across the cortical and outer medullary collecting duct.	Water	51-56	aquaporin 3	Mus musculus	13-17
11792767-7	2002	Low solute sieving across the peritoneal membrane was first identified in 1966, a phenomenon that is now attributed to the presence of water-only transport pathways mediated by aquaporin-1.	Water	135-140	aquaporin 1 (Colton blood group)	Homo sapiens	177-188
11952238-2	2002	Aquaporin-1, the water channel of human erythrocytes, is the first channel demonstrated to conduct water, by expression in Xenopus oocytes.	Water	17-22	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
11952238-2	2002	Aquaporin-1, the water channel of human erythrocytes, is the first channel demonstrated to conduct water, by expression in Xenopus oocytes.	Water	99-104	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
12182551-10	2002	Water contact angles and XPS, used to characterize the surfaces, suggest that there was some PEO enrichment at the surface of the polymers.	Water	0-5	twinkle mtDNA helicase	Homo sapiens	93-96
12017983-4	2002	We report an 18-year-old diabetic female with rapid insulin-induced weight gain due to excessive body water retention, found by serial BIA measurement.	Water	102-107	insulin	Homo sapiens	52-59
11837439-9	2002	There was an increase in N2O release as the overlying water NO3- concentration increased.	Water	54-59	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
12134630-2	2002	The CF gene codes for a transmembrane glycoprotein called CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), a chloride channel which regulates the luminal secretion of chloride and the active ion and water transport in the airway epithelial cells.	Water	210-215	CF transmembrane conductance regulator	Homo sapiens	58-62
12134630-2	2002	The CF gene codes for a transmembrane glycoprotein called CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), a chloride channel which regulates the luminal secretion of chloride and the active ion and water transport in the airway epithelial cells.	Water	210-215	CF transmembrane conductance regulator	Homo sapiens	64-115
11885981-4	2002	Furthermore, when amide-lipid NOEs were combined with amide-water chemical exchange cross-peaks of selectively 15N-labeled P16 peptides, valuable information was obtained about the position of selected residues relative to the membrane-water interface.	Water	236-241	cyclin dependent kinase inhibitor 2A	Homo sapiens	123-126
12017983-10	2002	Rapid weight gain shortly after insulin therapy may be due to excessive but reversible water retention, detected by repeated BIA measurements.	Water	87-92	insulin	Homo sapiens	32-39
12358694-5	2002	Water-soluble filter-sterile extracts were tested for their ability to inhibit growth of E. coli and several indicator microorganisms and to inhibit adhesion of ETEC K88.	Water	0-5	ETEC	Sus scrofa	161-165
11888178-1	2002	Rain data are collected all over the world because water is of paramount importance to all human life.	Water	51-56	Ras interacting protein 1	Homo sapiens	0-4
11773613-1	2002	The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of how water specifically crosses biological membranes.	Water	91-96	aquaporin 1 (Colton blood group)	Homo sapiens	17-28
11773613-1	2002	The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of how water specifically crosses biological membranes.	Water	91-96	aquaporin 1 (Colton blood group)	Homo sapiens	30-34
11773613-4	2002	AQP2 is exclusively expressed in the principal cells of the connecting tubule and collecting duct and is the predominant vasopressin-regulated water channel.	Water	143-148	arginine vasopressin	Homo sapiens	121-132
11773613-11	2002	Vasopressin regulates acutely the water permeability of the kidney collecting duct by trafficking of AQP2 from intracellular vesicles to the apical plasma membrane.	Water	34-39	arginine vasopressin	Homo sapiens	0-11
12436927-3	2002	Fortunately, the degree of the hyponatremia is limited by a process that counters the water-retaining action of vasopressin, namely "vasopressin escape".	Water	86-91	arginine vasopressin	Rattus norvegicus	112-123
12436927-3	2002	Fortunately, the degree of the hyponatremia is limited by a process that counters the water-retaining action of vasopressin, namely "vasopressin escape".	Water	86-91	arginine vasopressin	Rattus norvegicus	133-144
12436927-8	2002	Using this model, we demonstrated that the onset of vasopressin escape (increased urine volume coupled to decreased urine osmolality) coincided temporally with a marked decrease in renal aquaporin-2 (water channel) protein and mRNA expression in renal collecting ducts.	Water	200-205	arginine vasopressin	Rattus norvegicus	52-63
11981455-5	2002	Pre-incubation of the cells with the MPO-specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) and the heme enzyme inhibitor 3-aminotriazole (100 microM each) resulted in complete and partial inhibition, respectively, of intracellular MPO, caspase-3 activity, and apoptosis following addition of 50 microM H(2)O(2).	Water	308-313	myeloperoxidase	Homo sapiens	37-40
11812914-8	2002	Dialysis water quality (both chemical and biological) is also important in determining the response to epoetin; "ultrapure" water reduces epoetin requirements.	Water	9-14	erythropoietin	Homo sapiens	103-110
11812914-8	2002	Dialysis water quality (both chemical and biological) is also important in determining the response to epoetin; "ultrapure" water reduces epoetin requirements.	Water	124-129	erythropoietin	Homo sapiens	138-145
12027013-1	2002	The water-selective pathway through aquaporin 1 (AQP1) membrane channel has been visualized by fitting an atomic model to a 3.7 A resolution three-dimensional density map.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	36-47
12027013-1	2002	The water-selective pathway through aquaporin 1 (AQP1) membrane channel has been visualized by fitting an atomic model to a 3.7 A resolution three-dimensional density map.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	49-53
12431131-2	2002	One of the principal mechanisms controlling urine output is vasopressin which is released from the posterior pituitary gland and enhances water reabsorption from the renal collecting duct.	Water	138-143	arginine vasopressin	Homo sapiens	60-71
12431131-11	2002	In a small number of children the defect is a primary abnormality of the vasopressin receptor or one of the water channel proteins (aquaporins) involved in water transport.	Water	108-113	arginine vasopressin	Homo sapiens	73-84
12006677-8	2002	Double transgenic mice expressing both the hREN gene and SYN-hAGT transgene exhibited normal BP and water intake but had an increased preference for salt.	Water	100-105	joined toes	Mus musculus	57-60
12099765-1	2002	Inhalation of ultrasonically nebulised distilled water (fog) induces cough; however, the receptor type(s) mediating this reflex are poorly defined.	Water	49-54	zinc finger protein, FOG family member 1	Homo sapiens	56-59
12391575-0	2002	Effect of water treatment on analyte and matrix ion yields in matrix-assisted time-of-flight secondary ion mass spectrometry: the case of insulin in and on hydroxycinnamic acid.	Water	10-15	insulin	Homo sapiens	138-145
12391575-8	2002	Water treatment resulted in a pronounced decrease in the 4HCCA yield, typically by a factor of five, in parallel with an increase of the insulin yield, by up to a factor of four.	Water	0-5	insulin	Homo sapiens	137-144
12391575-11	2002	The typically 20-fold increase in the insulin-to-4HCCA yield ratio, generated by water exposure of the samples, provides the explanation for the high yield ratios observed previously with water-treated samples.	Water	81-86	insulin	Homo sapiens	38-45
12391575-11	2002	The typically 20-fold increase in the insulin-to-4HCCA yield ratio, generated by water exposure of the samples, provides the explanation for the high yield ratios observed previously with water-treated samples.	Water	188-193	insulin	Homo sapiens	38-45
12391575-12	2002	Spraying with water or repeated exposure to water droplets caused a pronounced degradation of the insulin parent yields in combination with an increasing appearance of signals due to the B- and A-chains of insulin.	Water	14-19	insulin	Homo sapiens	98-105
12391575-12	2002	Spraying with water or repeated exposure to water droplets caused a pronounced degradation of the insulin parent yields in combination with an increasing appearance of signals due to the B- and A-chains of insulin.	Water	14-19	insulin	Homo sapiens	206-213
12391575-12	2002	Spraying with water or repeated exposure to water droplets caused a pronounced degradation of the insulin parent yields in combination with an increasing appearance of signals due to the B- and A-chains of insulin.	Water	44-49	insulin	Homo sapiens	98-105
12391575-12	2002	Spraying with water or repeated exposure to water droplets caused a pronounced degradation of the insulin parent yields in combination with an increasing appearance of signals due to the B- and A-chains of insulin.	Water	44-49	insulin	Homo sapiens	206-213
12391575-16	2002	With both methods of sample preparation, however, high secondary ion yields of insulin were only obtained after exposure of the samples to water.	Water	139-144	insulin	Homo sapiens	79-86
11785064-9	2002	Also, activation of the renin-angiotensin system increases the levels of angiotensin II in the plasma, leading to generalized vasoconstriction, or locally in the kidneys, leading to salt and water retention.	Water	191-196	angiotensinogen	Homo sapiens	73-87
11598110-7	2001	Interestingly, the H(2)O(2)-induced activation of Akt was entirely mediated by upstream stimulation of PI 3"-kinase activity, since treatment of 3T3-L1 adipocytes with the PI 3"-kinase inhibitors wortmannin or LY294002 completely blocked the subsequent activation of Akt by exogenous H(2)O(2).	Water	19-24	AKT serine/threonine kinase 1	Homo sapiens	50-53
11598110-7	2001	Interestingly, the H(2)O(2)-induced activation of Akt was entirely mediated by upstream stimulation of PI 3"-kinase activity, since treatment of 3T3-L1 adipocytes with the PI 3"-kinase inhibitors wortmannin or LY294002 completely blocked the subsequent activation of Akt by exogenous H(2)O(2).	Water	19-24	AKT serine/threonine kinase 1	Homo sapiens	267-270
11773604-5	2001	Osmotic water permeability values for Aqp0(+/-) and Aqp0(-/-) lenses were reduced to approximately 46% and approximately 20% of wild-type values, respectively, and the focusing power of Aqp0(+/-) lenses was significantly lower than that of wild type.	Water	8-13	major intrinsic protein of lens fiber	Mus musculus	38-42
11773604-5	2001	Osmotic water permeability values for Aqp0(+/-) and Aqp0(-/-) lenses were reduced to approximately 46% and approximately 20% of wild-type values, respectively, and the focusing power of Aqp0(+/-) lenses was significantly lower than that of wild type.	Water	8-13	major intrinsic protein of lens fiber	Mus musculus	52-56
11773604-5	2001	Osmotic water permeability values for Aqp0(+/-) and Aqp0(-/-) lenses were reduced to approximately 46% and approximately 20% of wild-type values, respectively, and the focusing power of Aqp0(+/-) lenses was significantly lower than that of wild type.	Water	8-13	major intrinsic protein of lens fiber	Mus musculus	52-56
11780053-0	2001	Structural basis of water-specific transport through the AQP1 water channel.	Water	20-25	aquaporin 1 (Colton blood group)	Homo sapiens	57-61
11780053-0	2001	Structural basis of water-specific transport through the AQP1 water channel.	Water	62-67	aquaporin 1 (Colton blood group)	Homo sapiens	57-61
11780053-4	2001	In mammals, there are currently 10 families of water channels, referred to as aquaporins (AQP): AQP0-AQP9.	Water	47-52	major intrinsic protein of lens fiber	Homo sapiens	96-100
11780053-4	2001	In mammals, there are currently 10 families of water channels, referred to as aquaporins (AQP): AQP0-AQP9.	Water	47-52	aquaporin 9	Homo sapiens	101-105
11780053-5	2001	Here we report the structure of the aquaporin 1 (AQP1) water channel to 2.2 A resolution.	Water	55-60	aquaporin 1 (Colton blood group)	Homo sapiens	36-47
11744329-4	2001	Bcl-2 transfectants of both cell lines were more resistant to H(2)O(2) and showed increases in GSH level and Cu/Zn-superoxide dismutase (SOD1) activity, but not in Mn-superoxide dismutase, glutathione peroxidase, or glutathione reductase activities.	Water	62-67	BCL2 apoptosis regulator	Homo sapiens	0-5
11590144-6	2001	Furthermore, the downstream effector of PI3K, protein kinase B/AKT, is activated by NRG in the presence of H(2)O(2), and protein kinase B/AKT activation is inhibited by LY294002.	Water	107-112	AKT serine/threonine kinase 1	Homo sapiens	63-66
11717407-1	2001	Molecular-dynamics simulations were performed on the structures of the water channel aquaporin-1.	Water	71-76	aquaporin 1 (Colton blood group)	Homo sapiens	85-96
11717407-8	2001	Moreover, mutations based on the simulation also have been suggested for further experimental investigation of the water-permeation mechanism of aquaporin-1.	Water	115-120	aquaporin 1 (Colton blood group)	Homo sapiens	145-156
11717483-1	2001	A single-crystal neutron diffraction study of cyclodecaamylose (CA10) was carried out at 20 K. CA10 crystallizes with 27.18 water molecules [(C(6)H(10)O(5))(10).27.18H(2)O] in space group C2 with unit-cell constants a = 29.31 (5), b = 9.976 (10), c = 19.34 (2) A, beta = 121.07 (2) degrees.	Water	124-129	carbonic anhydrase 10	Homo sapiens	64-68
11717483-1	2001	A single-crystal neutron diffraction study of cyclodecaamylose (CA10) was carried out at 20 K. CA10 crystallizes with 27.18 water molecules [(C(6)H(10)O(5))(10).27.18H(2)O] in space group C2 with unit-cell constants a = 29.31 (5), b = 9.976 (10), c = 19.34 (2) A, beta = 121.07 (2) degrees.	Water	124-129	carbonic anhydrase 10	Homo sapiens	95-99
11717483-5	2001	A total of 13.59 water molecules in the asymmetric unit are distributed over 23 positions; 20 of which are in the CA10 cavity, and the other three occupy intermolecular interstices.	Water	17-22	carbonic anhydrase 10	Homo sapiens	114-118
11717483-7	2001	Water molecules and O-H groups of CA10 form an extended network with cooperative O-H...O-H...O-H hydrogen bonds.	Water	0-5	carbonic anhydrase 10	Homo sapiens	34-38
11577079-10	2001	We also report the activation of NF-kappaB DNA binding by the automodification reaction of PARP-1 in cultured HeLa cells following exposure to H(2)O(2).	Water	143-148	nuclear factor kappa B subunit 1	Homo sapiens	33-42
11577079-10	2001	We also report the activation of NF-kappaB DNA binding by the automodification reaction of PARP-1 in cultured HeLa cells following exposure to H(2)O(2).	Water	143-148	poly(ADP-ribose) polymerase 1	Homo sapiens	91-97
11780053-5	2001	Here we report the structure of the aquaporin 1 (AQP1) water channel to 2.2 A resolution.	Water	55-60	aquaporin 1 (Colton blood group)	Homo sapiens	49-53
11701449-4	2001	Treatment with GH increased C(Li) and changed the tubular handling of sodium and water.	Water	81-86	growth hormone 1	Homo sapiens	15-17
11701449-6	2001	The data demonstrate that GH-induced activation of the RAAS can be blocked by concomitant PG synthesis inhibition and that the tubular effects of GH include increased distal nephron sodium and water reabsorption.	Water	193-198	growth hormone 1	Homo sapiens	26-28
11701449-1	2001	To investigate the mechanisms behind the water- and sodium-retaining effects of growth hormone (GH), we studied the effect of GH on 1) water and sodium homeostasis, 2) the renin-angiotensin-aldosterone system (RAAS), and 3) lithium clearance (C(Li)) with and without concomitant prostaglandin (PG) synthesis inhibition with ibuprofen.	Water	41-46	growth hormone 1	Homo sapiens	80-94
11701449-6	2001	The data demonstrate that GH-induced activation of the RAAS can be blocked by concomitant PG synthesis inhibition and that the tubular effects of GH include increased distal nephron sodium and water reabsorption.	Water	193-198	growth hormone 1	Homo sapiens	146-148
11701449-1	2001	To investigate the mechanisms behind the water- and sodium-retaining effects of growth hormone (GH), we studied the effect of GH on 1) water and sodium homeostasis, 2) the renin-angiotensin-aldosterone system (RAAS), and 3) lithium clearance (C(Li)) with and without concomitant prostaglandin (PG) synthesis inhibition with ibuprofen.	Water	41-46	growth hormone 1	Homo sapiens	96-98
11679273-1	2001	The fiber-optic biosensor consisting of an acetylcholinesterase (AChE)-immobilized Langmuir-Blodgett (LB) film was developed to detect organophosphorus compounds in contaminated water.	Water	178-183	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-69
11743202-0	2001	Water permeation across biological membranes: mechanism and dynamics of aquaporin-1 and GlpF.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	72-83
11743202-1	2001	"Real time" molecular dynamics simulations of water permeation through human aquaporin-1 (AQP1) and the bacterial glycerol facilitator GlpF are presented.	Water	46-51	aquaporin 1 (Colton blood group)	Homo sapiens	77-88
11743202-1	2001	"Real time" molecular dynamics simulations of water permeation through human aquaporin-1 (AQP1) and the bacterial glycerol facilitator GlpF are presented.	Water	46-51	aquaporin 1 (Colton blood group)	Homo sapiens	90-94
11743202-5	2001	In AQP1, a fine-tuned water dipole rotation during passage is essential for water selectivity.	Water	22-27	aquaporin 1 (Colton blood group)	Homo sapiens	3-7
11743202-5	2001	In AQP1, a fine-tuned water dipole rotation during passage is essential for water selectivity.	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	3-7
11785303-6	2001	Tap water boiled for 2 h in an aluminum vessel has virtually no genotoxic effect on wheat cells.	Water	4-9	common wheat expressed sequence tag	Triticum aestivum	0-3
11738060-6	2001	In cultured rat cardiac myocytes, significant amounts of MIF were produced in response to hypoxia and hydrogen peroxide (H(2)O(2)), but not to angiotensin II, endothelin-1, interleukin-1beta (IL-1beta) or tumor necrosis factor alpha (TNFalpha).	Water	121-126	macrophage migration inhibitory factor	Rattus norvegicus	57-60
11954662-14	2001	These changes might impair renal tubular Na+ reabsorption and hence increase Na+ and water excretion in ACTH stimulation, thus acting as a counterbalance to normalize blood pressure in ACTH-stimulated animals.	Water	85-90	proopiomelanocortin	Homo sapiens	104-108
11848043-0	2001	Water-imbalance-induced expression of FGF-2 in fluid-regulatory centers: choroid plexus and neurohypophysis.	Water	0-5	fibroblast growth factor 2	Homo sapiens	38-43
11745754-3	2001	Using the analytical equations derived from the model and experimental sugar content dependencies of the water sorption at various relative humidities, the amount of hydration water for bovine serum albumin, and the minimum amount of sugar to embed the protein were determined.	Water	176-181	albumin	Homo sapiens	193-206
11447308-4	2001	ET(B) receptors may mediate some critical processes in the kidney such as sodium and water excretion in addition to releasing vasodilator substances such as NO and prostacyclin from endothelial cells.	Water	85-90	endothelin receptor type B	Homo sapiens	0-4
11740905-6	2001	The pulse sequences are demonstrated on two proteins, 30.4-kDa Cel6A in diluted liquid crystal phase and 18-kDa human cardiac troponin C in water.	Water	140-145	troponin C1, slow skeletal and cardiac type	Homo sapiens	118-136
11883203-13	2001	The water tub bath during delivery was estimated good by all of the women.	Water	4-9	TUB bipartite transcription factor	Homo sapiens	10-13
11724902-0	2001	Tissue distribution and membrane localization of aquaporin-9 water channel: evidence for sex-linked differences in liver.	Water	61-66	aquaporin 9	Rattus norvegicus	49-60
11724902-1	2001	Aquaporin-9 (AQP9) is a water channel membrane protein also permeable to small solutes such as urea, glycerol, and 5-fluorouracil, a chemotherapeutic agent.	Water	24-29	aquaporin 9	Rattus norvegicus	0-11
11724902-1	2001	Aquaporin-9 (AQP9) is a water channel membrane protein also permeable to small solutes such as urea, glycerol, and 5-fluorouracil, a chemotherapeutic agent.	Water	24-29	aquaporin 9	Rattus norvegicus	13-17
11785697-1	2001	PURPOSE: The aim of this study was to assess insulin stability by monitoring in situ time-course of insulin aggregation induced by a water-organic solvent (o/w) interface that occurs during the microencapsulation process.	Water	133-138	insulin	Homo sapiens	45-52
11850235-4	2001	Constructs encoding the native and chimeric porcine and human P450arom enzymes were transiently expressed and activity was assessed using the tritiated water assay.	Water	152-157	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	62-70
11750883-12	2001	The DAGAT activity was restored from delipidated oil bodies and from microsomes after the preparations had been resuspended in methanol/acetic acid/water (1:1:1, v/v).	Water	148-153	Diacylglycerol O-acyltransferase 1-2	Zea mays	4-9
11786201-4	2001	The correlations observed between plasma osmolality and CAP, and plasma CAP and ACE suggested a contribution of these activities to the restoration of basal water-electrolyte and blood pressure conditions through the hydrolysis of vasopressin, oxytocin, angiotensin I and bradykinin.	Water	157-162	angiotensin I converting enzyme	Rattus norvegicus	80-83
11786201-4	2001	The correlations observed between plasma osmolality and CAP, and plasma CAP and ACE suggested a contribution of these activities to the restoration of basal water-electrolyte and blood pressure conditions through the hydrolysis of vasopressin, oxytocin, angiotensin I and bradykinin.	Water	157-162	arginine vasopressin	Rattus norvegicus	231-242
11712605-5	2001	Seventy percent of the variation of the PCB particulate-dissolved phase coefficient (Kd) was correlated with temperature and log octanol-water (Kow)).	Water	137-142	pyruvate carboxylase	Homo sapiens	40-43
11682148-3	2001	In this study we observed that intracerebroventricular (ICV) injection of human NPFF, at early light phase in fasted rats, acutely reduced food intake and caused a large increase in water intake compared with saline injected controls.	Water	182-187	neuropeptide FF-amide peptide precursor	Homo sapiens	80-84
11546818-2	2001	A surface accessibility investigation for two structurally well-defined proteins, tendamistat and bovine pancreatic trypsin inhibitor, is performed here by a combined analysis of water-protein Overhauser effects and paramagnetic perturbation profiles induced by the soluble spin-label 4-hydroxy-2,2,6,6-tetramethyl-piperidine-1-oxyl on NMR spectra.	Water	179-184	trophoblast Kunitz domain protein 1	Bos taurus	116-133
12805827-7	2001	The average NO3--N concentration in tile drainwater was 18.8 and 3.2 mg/l in borehole water on farms where both were monitored.	Water	46-51	NBL1, DAN family BMP antagonist	Homo sapiens	12-15
11689072-8	2001	The larger chlorine atom displaces a water molecule (H(2)O1(S1)) that binds near residue 190 in all the complexes of 1, and related inhibitors, in uPA, thrombin, and trypsin.	Water	37-42	plasminogen activator, urokinase	Homo sapiens	147-150
11689072-8	2001	The larger chlorine atom displaces a water molecule (H(2)O1(S1)) that binds near residue 190 in all the complexes of 1, and related inhibitors, in uPA, thrombin, and trypsin.	Water	37-42	coagulation factor II, thrombin	Homo sapiens	152-160
11696353-1	2001	In an attempt to isolate protein kinase A anchoring proteins (AKAPs) involved in vasopressin-mediated water reabsorbtion, the complete sequence of the human AKAP Ht31 was determined and a partial cDNA of its rat orthologue (Rt31) was cloned.	Water	102-107	arginine vasopressin	Homo sapiens	81-92
11696353-8	2001	Ht31/Rt31 have the potential to integrate Rho and protein kinase A signaling pathways, and thus, are prime candidates to regulate vasopressin-mediated water reabsorbtion.	Water	151-156	A-kinase anchoring protein 13	Homo sapiens	0-4
11696353-8	2001	Ht31/Rt31 have the potential to integrate Rho and protein kinase A signaling pathways, and thus, are prime candidates to regulate vasopressin-mediated water reabsorbtion.	Water	151-156	arginine vasopressin	Homo sapiens	130-141
11743870-0	2001	Internal water molecules as mobile polar groups for light-induced proton translocation in bacteriorhodopsin and rhodopsin as studied by difference FTIR spectroscopy.	Water	9-14	rhodopsin	Homo sapiens	98-107
11717661-12	2001	These results suggest that aquaporin-8 may be a water channel that mediates amniotic fluid resorption by way of the intramembranous pathway.	Water	48-53	aquaporin 8	Homo sapiens	27-38
11641146-1	2001	We examined the effects of hypotension and fluid depletion on water and sodium ingestion in rats in response to intracerebroventricular infusions of ANG II.	Water	62-67	angiotensinogen	Rattus norvegicus	149-155
11641146-3	2001	Hypotension increased water intake in response to intracerebroventricular ANG II (30 ng/h) but not intake of 0.3 M NaCl solution and caused significant urinary retention of water and sodium.	Water	22-27	angiotensinogen	Rattus norvegicus	74-80
11641146-5	2001	Fluid depletion increased water intake in response to the highest dose of intracerebroventricular ANG II but did not affect saline intake.	Water	26-31	angiotensinogen	Rattus norvegicus	98-104
11641146-6	2001	In the presence of captopril, fluid depletion increased intakes of both water and saline in response to both doses of intracerebroventricular ANG II.	Water	72-77	angiotensinogen	Rattus norvegicus	142-148
11641146-7	2001	Because captopril administration causes hypotension in fluid-depleted animals, the results of the two experiments suggest that hypotension in fluid-replete animals preferentially increases water intake in response to intracerebroventricular ANG II and in fluid-depleted animals increases both salt and water intake in response to intracerebroventricular ANG II.	Water	189-194	angiotensinogen	Rattus norvegicus	241-247
11696054-3	2001	METHODS: The sera of patients (10 atopic and 10 non-atopic) previously diagnosed as suffering from irritable bowel syndrome and complaining of symptoms after wheat ingestion were analysed by immunoblotting for IgE binding to water/salt-soluble and insoluble wheat flour proteins.	Water	225-230	immunoglobulin heavy constant epsilon	Homo sapiens	210-213
11731301-9	2001	The increase in selectivity results from the displacement of a single bound water molecule common to the S1 site of both the uPA target and the tPA anti-target because of the ensuing deficit in hydrogen bonding of the arylamidine inhibitor when bound in the Ala190 protease anti-target.	Water	76-81	plasminogen activator, urokinase	Homo sapiens	125-128
11731301-9	2001	The increase in selectivity results from the displacement of a single bound water molecule common to the S1 site of both the uPA target and the tPA anti-target because of the ensuing deficit in hydrogen bonding of the arylamidine inhibitor when bound in the Ala190 protease anti-target.	Water	76-81	plasminogen activator, tissue type	Homo sapiens	144-147
11828179-2	2001	In this regard, angiotensin II maintains and regulates salt and water balance, is critically involved in cardiovascular function, and governs thirst.	Water	64-69	angiotensinogen	Homo sapiens	16-30
11758006-7	2001	Correlation analysis revealed no relationship between plasma ANP and U(URO)V. CONCLUSIONS: Moderate variations in the levels of ANP in water-loaded volunteers do not induce parallel changes in the urinary excretion of urodilatin.	Water	135-140	natriuretic peptide A	Homo sapiens	128-131
11677212-10	2001	A polyethylene glycol drinking water solution resulted in diarrhea, higher gut-to-carcass ratios, and induction of guanylin and uroguanylin in both GC-C heterozygous and null animals.	Water	31-36	guanylate cyclase 2c	Mus musculus	148-152
11568845-14	2001	Sulfates (SO4) and nitrates (NO3) are found in the area in low concentrations, even below the WHO standards for drinking water, but are significantly higher in the surface water compared to the groundwater.	Water	121-126	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
11568845-14	2001	Sulfates (SO4) and nitrates (NO3) are found in the area in low concentrations, even below the WHO standards for drinking water, but are significantly higher in the surface water compared to the groundwater.	Water	172-177	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
11824790-0	2001	Expression and immunolocalization of the aquaporin-8 water channel in rat gastrointestinal tract.	Water	53-58	aquaporin 8	Rattus norvegicus	41-52
11824790-12	2001	The cellular and subcellular distribution of AQP8 suggest physiological roles for this aquaporin in the absorption of water in the intestine and the secretion of bile and pancreatic juice in liver and pancreas, respectively.	Water	118-123	aquaporin 8	Rattus norvegicus	45-49
11855180-5	2001	When the concentration of NO3(-)-N was 28.8 mg/L in inlet water, the optimum applied density was 9 mA, the highest hydraulic load of the reactor was 35 ml/h, and the reactor performed a practical buffering capacity to pH.	Water	58-63	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
11711512-11	2001	Extrarenal water losses, partly originating from the lung, were reduced by high plasma vasopressin level.	Water	11-16	arginine vasopressin	Rattus norvegicus	87-98
11855184-9	2001	With the increase of temperature and biomass, NH4+ and NO3- in the surface water were largely consumed and decreased as a result; while organic N and particle P increased as the enhancement of suspending biological particles.	Water	75-80	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
12369967-5	2001	Most of the A(3) AR antagonists are highly lipophilic and exhibit very poor water-solubility.	Water	76-81	adenosine A3 receptor	Homo sapiens	12-19
11484195-2	2001	Previously we reported that the water-soluble matrix (WSM) of nacre obtained from the inner shell layer of the oyster Pinctada maxima, promoted an increase in ALP activity that was dose-dependent.	Water	32-37	alkaline phosphatase, placental	Homo sapiens	159-162
11714141-9	2001	In pure water, GBL reacted to form an equilibrium mixture comprising ca.	Water	8-13	MTOR associated protein, LST8 homolog	Homo sapiens	15-18
11703600-8	2001	Switching from NaHCO(3) to distilled water resulted in rapid recovery of NHE-3 and NBC-1 protein expression toward normal levels.	Water	37-42	solute carrier family 4 member 4	Rattus norvegicus	83-88
11790013-5	2001	Depending on pH and total TNT concentration, the relative distribution of TNT* among water, POM, and DOM varied between 60 to 90, 10 to 30, and 0.5 to 6%, respectively, after 22 h of equilibration.	Water	85-90	chromosome 16 open reading frame 82	Homo sapiens	74-78
11763362-5	2001	In water, the structure is best described as a left-handed polyproline type II (PPII) helix for the mid segment region Asp2 to Pro6.	Water	3-8	beta-secretase 1	Homo sapiens	119-123
11676542-10	2001	For thrombin, smaller negative DeltaC(p) values are observed for ligand binding in the presence of sodium ions compared to the other alkali ions, probably due to stabilising effects on the protein or changes in the bound water structure.	Water	221-226	coagulation factor II, thrombin	Homo sapiens	4-12
11735996-2	2001	We have investigated the dynamics of protons along chains of hydrogen-bonded water molecules adsorbed on the surface of the globular protein lysozyme.	Water	77-82	lysozyme	Homo sapiens	141-149
11735996-4	2001	We find that the relaxation time diverges at a singular hydration that coincides with the critical water content required to trigger lysozyme enzymatic activity.	Water	99-104	lysozyme	Homo sapiens	133-141
11790410-7	2001	5-HT(1B) KO males drank strikingly more water.	Water	40-45	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	0-7
11790410-15	2001	Lifelong absence of 5-HT(1B) receptors in mice resulted in clear phenotypic differences in body weights and food and water intake.	Water	117-122	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	20-27
11536078-6	2001	In Xenopus oocytes injected with mutant AQP2 cRNAs, the osmotic water permeability (Pf) was much smaller than that of oocytes with the AQP2 wild-type (14%-17%).	Water	64-69	aquaporin 2 S homeolog	Xenopus laevis	40-44
11597928-7	2001	A specific inhibitor for CaM kinase II, KN93, and a calmodulin antagonist, W-7, attenuated eNOS induction by H(2)O(2).	Water	109-114	nitric oxide synthase 3	Bos taurus	91-95
11693606-1	2001	Bond Elut C18 solid-phase extraction cartridges were used for preconcentration and pre-column derivatization with 3,5-dinitrobenzoyl chloride (DNB) of aliphatic amines in water.	Water	171-176	Bardet-Biedl syndrome 9	Homo sapiens	10-13
11576341-1	2001	BACKGROUND: In a state of chronic arginine vasopressin (AVP) excess, the action of antidiuresis has been attenuated, resulting in some water diuresis.	Water	135-140	arginine vasopressin	Rattus norvegicus	43-54
11680608-0	2001	Expression of cyclooxygenase-2 in human neutrophils activated by Helicobacter pylori water-soluble proteins: possible involvement of NF-kappaB and MAP kinase signaling pathway.	Water	85-90	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-30
11573986-2	2001	Water deprivation reduced basal CRH mRNA levels but the increments following 4 h of restraint or 6 h lipopolysaccharide (LPS) injection were similar to those in controls.	Water	0-5	corticotropin releasing hormone	Rattus norvegicus	32-35
11573986-4	2001	VP expression in magnocellular paraventricular and supraoptic nuclei, and plasma sodium and vasopressin were higher in water-deprived rats, changes which were unaffected by restraint.	Water	119-124	arginine vasopressin	Rattus norvegicus	0-2
11573986-4	2001	VP expression in magnocellular paraventricular and supraoptic nuclei, and plasma sodium and vasopressin were higher in water-deprived rats, changes which were unaffected by restraint.	Water	119-124	arginine vasopressin	Rattus norvegicus	92-103
11532515-2	2001	Since a serious environmental contamination of areas in this locality with armament wastes containing toluene-derivatives has been known for a long time, the hypothesis arose that TNT production and the related severe contamination of soil and water might be responsible for the observed higher risk.	Water	244-249	chromosome 16 open reading frame 82	Homo sapiens	180-183
11581003-1	2001	DESIGN: Growth hormone (GH) has demonstrated water-retaining effects in subjects at rest, whereas other research has indicated that GH may stimulate sweating.	Water	45-50	growth hormone 1	Homo sapiens	8-22
11581003-1	2001	DESIGN: Growth hormone (GH) has demonstrated water-retaining effects in subjects at rest, whereas other research has indicated that GH may stimulate sweating.	Water	45-50	growth hormone 1	Homo sapiens	24-26
11573975-6	2001	Chronic (7-day) studies were performed in which vasopressin levels were elevated either endogenously by water restriction of Sprague-Dawley rats or exogenously through infusion of the vasopressin V2-receptor-selective agonist, dDAVP (1-deamino-8d-arginine-vasopressin), to Brattleboro rats.	Water	104-109	arginine vasopressin	Rattus norvegicus	48-59
11576341-1	2001	BACKGROUND: In a state of chronic arginine vasopressin (AVP) excess, the action of antidiuresis has been attenuated, resulting in some water diuresis.	Water	135-140	arginine vasopressin	Rattus norvegicus	56-59
11606828-2	2001	The Colton blood group antigens are expressed by the water channel aquaporin 1 (aqp1; also known as channel-forming integral protein, CHIP-28), which is a highly conserved RBC integral membrane protein.	Water	53-58	aquaporin 1 (Colton blood group)	Homo sapiens	80-84
11687943-4	2001	Furthermore, during glucose-induced osmosis during PD, nearly 40% of the total osmotic water flow occurs through molecular water channels, termed "aquaporin-1."	Water	87-92	aquaporin 1 (Colton blood group)	Homo sapiens	147-158
12060293-2	2001	This hypothesis is consistent with experimental evidence of the role of water as a limiting factor in (1) seed maturation and viviparous germination, (2) the elongation and phototropism of hypocotyls and coleoptiles, (3) the NO3--induced germination of dormant seeds, and (4) the release of buds from correlative inhibition.	Water	72-77	NBL1, DAN family BMP antagonist	Homo sapiens	225-228
11606828-2	2001	The Colton blood group antigens are expressed by the water channel aquaporin 1 (aqp1; also known as channel-forming integral protein, CHIP-28), which is a highly conserved RBC integral membrane protein.	Water	53-58	aquaporin 1 (Colton blood group)	Homo sapiens	134-141
11447225-8	2001	Furthermore, although H(2)O(2) strongly induced serine 15 phosphorylation of p53, it failed to induce serine 20 phosphorylation in Plk3-dificient Daudi cells.	Water	22-27	tumor protein p53	Homo sapiens	77-80
11447225-7	2001	Also serine 20-phosphorylated p53 was coimmunoprecipitated with Plk3 in cells treated with H(2)O(2).	Water	91-96	tumor protein p53	Homo sapiens	30-33
11447225-7	2001	Also serine 20-phosphorylated p53 was coimmunoprecipitated with Plk3 in cells treated with H(2)O(2).	Water	91-96	polo like kinase 3	Homo sapiens	64-68
11561613-1	2001	The influence of heating or boiling on the formation and behavior of disinfection by-products (DBPs) was investigated in DBP-spiked reagent water, municipal tap water, and synthetic water containing chlorinated aquatic humic substances.	Water	140-145	D-box binding PAR bZIP transcription factor	Homo sapiens	95-98
11559087-4	2001	This reaction presumably occurs by net double Cl-atom transfer to PPh3 to give Cl2PPh3 that subsequently undergoes hydrolysis by trace H2O to give the final product, OPPh3.	Water	135-138	caveolin 1	Homo sapiens	66-70
11578610-5	2001	Caloric vestibular stimulation with cold water increased the plasma VP levels to 262% of the control group, which received caloric stimulation with water at 37 degrees C, and stimulation with warm water tended to increase the plasma VP levels.	Water	41-46	arginine vasopressin	Rattus norvegicus	68-70
11578610-5	2001	Caloric vestibular stimulation with cold water increased the plasma VP levels to 262% of the control group, which received caloric stimulation with water at 37 degrees C, and stimulation with warm water tended to increase the plasma VP levels.	Water	41-46	arginine vasopressin	Rattus norvegicus	233-235
11560489-8	2001	Relative to the structure of PLA2, the subunit contact surface in proPLA2 displays a tilted orientation, an altered mode of inhibitor binding, displacement of a mechanistically significant loop that includes Tyr69, and a critical active site water seen in PLA2 that is not seen in proPLA2.	Water	242-247	phospholipase A2, major isoenzyme	Sus scrofa	29-33
11560489-8	2001	Relative to the structure of PLA2, the subunit contact surface in proPLA2 displays a tilted orientation, an altered mode of inhibitor binding, displacement of a mechanistically significant loop that includes Tyr69, and a critical active site water seen in PLA2 that is not seen in proPLA2.	Water	242-247	phospholipase A2, major isoenzyme	Sus scrofa	69-73
11560489-11	2001	Together, a comparison of the structures of the anion-assisted dimers of PLA2 and proPLA2 not only offers an explanation of why the zymogen form is k(cat)-impaired and binds poorly even to the anionic interface but also supports a mechanism for the activated enzyme that includes a critical second-sphere assisting water bridging His48 and the calcium-coordinated catalytic water.	Water	315-320	phospholipase A2, major isoenzyme	Sus scrofa	73-77
11560489-11	2001	Together, a comparison of the structures of the anion-assisted dimers of PLA2 and proPLA2 not only offers an explanation of why the zymogen form is k(cat)-impaired and binds poorly even to the anionic interface but also supports a mechanism for the activated enzyme that includes a critical second-sphere assisting water bridging His48 and the calcium-coordinated catalytic water.	Water	374-379	phospholipase A2, major isoenzyme	Sus scrofa	73-77
11551197-3	2001	The crystal structure of ATP A2 at 1.45 A resolution at 100 K showed a water molecule only 2.1 A from heme iron [Ostergaard, L., et al.	Water	71-76	peroxidase 2	Arabidopsis thaliana	25-31
11551525-6	2001	Pretreatment with dl-buthionine (SR)-sulfoximine, which decreased intracellular glutathione, increased NF-kappaB binding induced by H(2)O(2) and increased lactate dehydrogenase (LDH) release (P &lt; 0.001).	Water	132-137	nuclear factor kappa B subunit 1	Homo sapiens	103-112
11518698-1	2001	Aquaporin-2 (AQP-2) is the vasopressin-regulated water channel expressed in the apical membrane of principal cells in the collecting duct and is involved in the urinary concentrating mechanism.	Water	49-54	arginine vasopressin	Rattus norvegicus	27-38
11524020-2	2001	It was found that PT insulin has a highly flexible structure in pure water and is present in at least two different conformations, although with an overall tertiary structure similar to that of native insulin.	Water	69-74	insulin	Homo sapiens	21-28
11524020-5	2001	In contrast, in TFE/water solution the mutant reveals a propensity of forming a well-defined structure at the secondary structure level, similar to monomeric native insulin.	Water	20-25	insulin	Homo sapiens	165-172
11524020-8	2001	The obtained results suggest that only an overall tertiary fold, as observed for PT insulin in pure water, is necessary for expressing the biological activity of insulin, as long as the molecule is flexible and retains the propensity to form the secondary structure required for its receptor binding.	Water	100-105	insulin	Homo sapiens	84-91
11524020-8	2001	The obtained results suggest that only an overall tertiary fold, as observed for PT insulin in pure water, is necessary for expressing the biological activity of insulin, as long as the molecule is flexible and retains the propensity to form the secondary structure required for its receptor binding.	Water	100-105	insulin	Homo sapiens	162-169
11783639-3	2001	Water removal from municipal reservoirs increases the downstream concentration of NO3- and SO4(2-) over that predicted by land use changes, showing that removal of high quality upstream water concentrates pollutants downstream.	Water	0-5	NBL1, DAN family BMP antagonist	Homo sapiens	82-85
11783639-3	2001	Water removal from municipal reservoirs increases the downstream concentration of NO3- and SO4(2-) over that predicted by land use changes, showing that removal of high quality upstream water concentrates pollutants downstream.	Water	186-191	NBL1, DAN family BMP antagonist	Homo sapiens	82-85
11518698-2	2001	In the rat distal colon, vasopressin stimulates water absorption through an unknown mechanism.	Water	48-53	arginine vasopressin	Rattus norvegicus	25-36
11803485-7	2001	At nontoxic concentrations of tBH and H(2)O(2), a dose dependent increase in FGF-2 expression was seen as a function of culture density.	Water	38-43	fibroblast growth factor 2	Homo sapiens	77-82
11509366-1	2001	We determined the influence of the two hydrophobic proteins, SP-B and SP-C, on the thermodynamic barriers that limit adsorption of pulmonary surfactant to the air-water interface.	Water	163-168	surfactant protein B	Bos taurus	61-65
11589680-10	2001	The wt GR has direct and water mediated contact with the phosphate groups of the glucocorticoid responsive element (GRE) whereas, in the model, the mutation R477H has no contact with the GRE.	Water	25-30	nuclear receptor subfamily 3 group C member 1	Homo sapiens	7-9
11599777-9	2001	ANG II receptor block reduced the Vo2 response and prevented the decrease in V/Vo2 following water loading by oral gavage, but did not affect the transient stimulation of V. Unlike larger mammals, decreased osmolality does not stimulate respiration in the SD rat.	Water	93-98	angiotensinogen	Rattus norvegicus	0-6
11504796-1	2001	We compared the effects of dopamine and norepinephrine on vasopressin (AVP)-stimulated increases in osmotic water permeability (Pf) and cAMP accumulation in the rat inner medullary collecting duct (IMCD).	Water	108-113	arginine vasopressin	Rattus norvegicus	58-69
11683923-0	2001	Caspase-3 activity and expression of Bcl-2 family in human neutrophils by Helicobacter pylori water-soluble proteins.	Water	94-99	caspase 3	Homo sapiens	0-9
11683923-0	2001	Caspase-3 activity and expression of Bcl-2 family in human neutrophils by Helicobacter pylori water-soluble proteins.	Water	94-99	BCL2 apoptosis regulator	Homo sapiens	37-42
11549643-11	2001	In both men and women, the total body water and fat free mass increases were closely related to the IGF-I increments (P &lt; 0.001 by Pearson"s correlation test).	Water	38-43	insulin like growth factor 1	Homo sapiens	100-105
11549643-16	2001	Probably because of these gender differences in IGF-I responsivity, the increases of total body water and fat free mass to rhGH replacement were greater in men than in women.	Water	96-101	insulin like growth factor 1	Homo sapiens	48-53
11577858-6	2001	The NO3 concentrations were usually higher in water flowing from the sand aquifer than in water flowing from the basalt aquifer or in perched water tables in the basalt aquifer.	Water	46-51	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
11577858-6	2001	The NO3 concentrations were usually higher in water flowing from the sand aquifer than in water flowing from the basalt aquifer or in perched water tables in the basalt aquifer.	Water	90-95	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
11577858-6	2001	The NO3 concentrations were usually higher in water flowing from the sand aquifer than in water flowing from the basalt aquifer or in perched water tables in the basalt aquifer.	Water	90-95	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
11578104-0	2001	Improved activity and stability of lysozyme at the water/CH2Cl2 interface: enzyme unfolding and aggregation and its prevention by polyols.	Water	51-56	lysozyme	Homo sapiens	35-43
11578104-3	2001	When lysozyme was exposed to a large water/CH2Cl2 interface achieved by homogenization, lysozyme aggregation occurred.	Water	37-42	lysozyme	Homo sapiens	5-13
11578104-3	2001	When lysozyme was exposed to a large water/CH2Cl2 interface achieved by homogenization, lysozyme aggregation occurred.	Water	37-42	lysozyme	Homo sapiens	88-96
11578104-6	2001	The observed loss in specific enzyme activity of soluble lysozyme was caused by the irreversible formation of an unfolded lysozyme species, which was found to be monomeric, and was able to leave the water/CH2Cl2 interface and accumulate in the aqueous phase.	Water	199-204	lysozyme	Homo sapiens	57-65
11578104-6	2001	The observed loss in specific enzyme activity of soluble lysozyme was caused by the irreversible formation of an unfolded lysozyme species, which was found to be monomeric, and was able to leave the water/CH2Cl2 interface and accumulate in the aqueous phase.	Water	199-204	lysozyme	Homo sapiens	122-130
11769217-2	2001	In the research of laboratory, when the voltage between two electrodes was 12 kV, 4 x 10(3) Pa H2S was discharged in air for 5 seconds, about 100% of H2S was transformed into H2O and SO2; 1.33 x 10(3) Pa CS2 was discharged in air for 15 seconds, about 80% of CS2 was transformed into CO2, CO and SO2.	Water	175-178	chorionic somatomammotropin hormone 2	Homo sapiens	204-207
11769217-2	2001	In the research of laboratory, when the voltage between two electrodes was 12 kV, 4 x 10(3) Pa H2S was discharged in air for 5 seconds, about 100% of H2S was transformed into H2O and SO2; 1.33 x 10(3) Pa CS2 was discharged in air for 15 seconds, about 80% of CS2 was transformed into CO2, CO and SO2.	Water	175-178	chorionic somatomammotropin hormone 2	Homo sapiens	259-262
11693469-1	2001	In the freshwater pulmonate pond snail and flateye snail, contact of the pneumostoma (the respiratory organ) with the water surface and tactile stimulation of the mantle induced phase-coordinated excitation and inhibition of activation of symmetrical pedal neurons RPeD1 (the GDC--giant dopamine cell) and LPeD1 (the GSC--giant serotonin cell).	Water	12-17	snail family transcriptional repressor 1	Homo sapiens	33-38
11410596-2	2001	The aquaporin-1 (AQP1) water channel protein is known to facilitate the rapid movement of water across cell membranes, but a proposed secondary role as an ion channel is still unsettled.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	4-15
12580109-3	2001	The mobile phase consisted of acetonitrile-water-formic acid (20:80:1), at a flow-rate of 0.4 mL.min-1.	Water	43-48	CD59 molecule (CD59 blood group)	Homo sapiens	97-102
11580389-1	2001	We study the potential energy surface (PES) sampled by a liquid modeled via the widely studied extended simple point charge (SPC/E) model for water.	Water	142-147	proline rich protein gene cluster	Homo sapiens	125-128
11597198-0	2001	Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta.	Water	0-5	aquaporin 9	Homo sapiens	32-36
11597198-5	2001	Since AQP3 is not only a water channels, but also permits the rapid passage of both urea and glycerol, while AQP9 also mediates the passage of carbamides, polyols, purines, and pyrimidines, we have speculated that these proteins could be involved in the transport of water and solutes from mother to fetus.	Water	267-272	aquaporin 9	Homo sapiens	109-113
11532455-1	2001	A refined structure of the human water channel aquaporin-1 is presented.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	47-58
11532455-5	2001	Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel.	Water	133-138	aquaporin 1 (Colton blood group)	Homo sapiens	25-36
11532456-0	2001	Molecular dynamics study of aquaporin-1 water channel in a lipid bilayer.	Water	40-45	aquaporin 1 (Colton blood group)	Homo sapiens	28-39
11532456-1	2001	The aquaporin-1 water channel was modeled in a palmitoyl-oleoyl-phosphatidyl-choline lipid bilayer, by means of molecular dynamics simulations.	Water	16-21	aquaporin 1 (Colton blood group)	Homo sapiens	4-15
11498256-3	2001	Biozzi ABH mice were found to be susceptible to EAU induction with native bovine IRBP.	Water	48-51	alkB homolog 1, histone H2A dioxygenase	Mus musculus	7-10
11527586-1	2001	The complex formed by the interaction of the amphiphilic penicillin drug nafcillin and human serum albumin (HSA) in water at 25 degrees C has been characterised using a range of physicochemical techniques.	Water	116-121	albumin	Homo sapiens	93-106
11410596-2	2001	The aquaporin-1 (AQP1) water channel protein is known to facilitate the rapid movement of water across cell membranes, but a proposed secondary role as an ion channel is still unsettled.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	17-21
11410596-2	2001	The aquaporin-1 (AQP1) water channel protein is known to facilitate the rapid movement of water across cell membranes, but a proposed secondary role as an ion channel is still unsettled.	Water	90-95	aquaporin 1 (Colton blood group)	Homo sapiens	4-15
11410596-2	2001	The aquaporin-1 (AQP1) water channel protein is known to facilitate the rapid movement of water across cell membranes, but a proposed secondary role as an ion channel is still unsettled.	Water	90-95	aquaporin 1 (Colton blood group)	Homo sapiens	17-21
11410596-3	2001	Here we describe a method to simultaneously measure water permeability and ion conductance of purified human AQP1 after reconstitution into planar lipid bilayers.	Water	52-57	aquaporin 1 (Colton blood group)	Homo sapiens	109-113
11410596-5	2001	Comparisons with the known single channel water permeability of AQP1 indicate that the planar lipid bilayers contain from 10(6) to 10(7) water channels.	Water	42-47	aquaporin 1 (Colton blood group)	Homo sapiens	64-68
11410596-5	2001	Comparisons with the known single channel water permeability of AQP1 indicate that the planar lipid bilayers contain from 10(6) to 10(7) water channels.	Water	137-142	aquaporin 1 (Colton blood group)	Homo sapiens	64-68
11410596-10	2001	Deletion of the putative cGMP binding motif at the C terminus by introduction of a stop codon at position 237 yielded a truncated AQP1 protein that was still permeated by water but not by ions.	Water	171-176	aquaporin 1 (Colton blood group)	Homo sapiens	130-134
11502182-2	2001	Hydrogen bonding of these water molecules to the protein backbone or side chains may contribute favorably to the Ca2+ affinity, as suggested in an earlier study of two calbindin D(9k) mutants [E60D and E60Q; Linse et al.	Water	26-31	S100 calcium binding protein G	Homo sapiens	168-182
11502182-4	2001	To investigate the generality of this conclusion, another side chain, Gln 22, which hydrogen bonds to a Ca2+-coordinating water molecule in calbindin D(9k), was mutated.	Water	122-127	S100 calcium binding protein G	Homo sapiens	140-154
11502182-0	2001	Symmetrical stabilization of bound Ca2+ ions in a cooperative pair of EF-hands through hydrogen bonding of coordinating water molecules in calbindin D(9k).	Water	120-125	S100 calcium binding protein G	Homo sapiens	139-153
11476729-3	2001	The development of nonpeptide AVP V2 receptor antagonists represents a promising treatment option to directly antagonize the effects of elevated plasma AVP concentrations by increasing the water permeability of renal collecting tubules, thereby promoting excretion of retained water and normalizing hypoosmolar hyponatremia.	Water	189-194	arginine vasopressin	Homo sapiens	30-33
11476737-5	2001	Vasopressin regulates water and ion transport through V2 receptor-mediated ion channels and transporters.	Water	22-27	arginine vasopressin	Homo sapiens	0-11
11476729-3	2001	The development of nonpeptide AVP V2 receptor antagonists represents a promising treatment option to directly antagonize the effects of elevated plasma AVP concentrations by increasing the water permeability of renal collecting tubules, thereby promoting excretion of retained water and normalizing hypoosmolar hyponatremia.	Water	189-194	arginine vasopressin	Homo sapiens	152-155
11476729-3	2001	The development of nonpeptide AVP V2 receptor antagonists represents a promising treatment option to directly antagonize the effects of elevated plasma AVP concentrations by increasing the water permeability of renal collecting tubules, thereby promoting excretion of retained water and normalizing hypoosmolar hyponatremia.	Water	277-282	arginine vasopressin	Homo sapiens	30-33
11493008-5	2001	In the first structure, a water molecule, made nucleophilic by coordination to His57 of alpha-thrombin, is bonded to the pentacoordinated phosphorus atom.	Water	26-31	coagulation factor II, thrombin	Homo sapiens	94-102
11397793-11	2001	Grx1 and Grx2 were sensitive to inactivation by iodoacetamide and H(2)O(2) and exhibited similar pH dependence of catalytic activity.	Water	66-72	glutaredoxin 2	Homo sapiens	9-13
11487658-8	2001	Stool water and colon motility were increased in most SERT -/- animals; however, the increase in motility (diarrhea) occasionally alternated irregularly with decreased motility (constipation).	Water	6-11	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	54-58
11513412-2	2001	Most of the organic matter responsible for the major DBP precursors in the Pan-Hsin water are small compounds with a molecular weight less than 1 kDa.	Water	84-89	D-box binding PAR bZIP transcription factor	Homo sapiens	53-56
11466204-3	2001	Therefore, we used a specific antibody to map the cellular distribution of another AQP, AQP9 (which is permeable to water and to some solutes), in the male reproductive tract.	Water	116-121	aquaporin 9	Rattus norvegicus	88-92
11569790-1	2001	Puddles of rain water on the surfaces of rock exposures are a little known but very common habitat for freshwater-dwelling animals.	Water	16-21	Rho kinase	Drosophila melanogaster	41-45
11482649-4	2001	It was found that riboflavin significantly enhanced the degradation of TNT in natural water environment.	Water	86-91	chromosome 16 open reading frame 82	Homo sapiens	71-74
11482649-5	2001	Thus it is a potentially useful photosensitizing agent for the treatment of TNT-contaminated surface water.	Water	101-106	chromosome 16 open reading frame 82	Homo sapiens	76-79
11513412-4	2001	Therefore, effective removal of small molecules or hydrophobic acidic organics prior to disinfection process will significantly reduce the DBP concentration in the finished water.	Water	173-178	D-box binding PAR bZIP transcription factor	Homo sapiens	139-142
11531928-1	2001	OBJECTIVE: The present study was undertaken to determine whether the hydro-osmotic action of arginine vasopressin (AVP) is exaggerated in pathological states of impaired water excretion by measuring urinary excretion of the aquaporin-2 (AQP-2) water channel.	Water	170-175	arginine vasopressin	Homo sapiens	102-113
11397633-0	2001	Rotational and translational dynamics of lysozyme in water-glycerol solution.	Water	53-58	lysozyme	Homo sapiens	41-49
11397633-2	2001	For this, we investigated the dynamical properties of lysozyme in mixtures water-glycerol by means of parallel measurements of photon correlation spectroscopy (PCS) and dielectric spectroscopy at radiofrequencies (DS).	Water	75-80	lysozyme	Homo sapiens	54-62
11397633-5	2001	In order to ascertain if this effect is present also in our sample, we performed PCS and DS measurements on lysozyme-water-glycerol solutions.	Water	117-122	lysozyme	Homo sapiens	108-116
11397633-9	2001	These results indicate that the diffusive behavior of lysozyme in the water-glycerol mixture is coherent with the Debye-Stokes-Einstein hydrodynamic model.	Water	70-75	lysozyme	Homo sapiens	54-62
11565844-0	2001	Substance P (free acid) adopts different conformation than native peptide in DMSO, water and DPPC bilayers.	Water	83-88	tachykinin precursor 1	Homo sapiens	0-11
12945278-2	2001	This method is based on the quenching of fluorescence of Triton X-100/n-C5H11OH/n-C9H20/H2O microemulsion system due to the formation of complex Ni(II)-SAF-Triton X-100.	Water	88-91	FAS antisense RNA 1	Homo sapiens	152-155
11513708-0	2001	Interface characterization and aging of bovine serum albumin stabilized oil-in-water emulsions as revealed by front-surface fluorescence.	Water	79-84	albumin	Homo sapiens	47-60
11565844-1	2001	The conformation of substance P (free acid) (SPOH) has been investigated in dimethylsulfoxide (DMSO), water and dipalmitoylphosphotidylcholine (DPPC) bilayers by two-dimensional NMR and restraint molecular dynamics simulations.	Water	102-107	tachykinin precursor 1	Homo sapiens	20-31
11523091-4	2001	The data obtained with lysozyme allow detection of minor conformational changes upon glycerol addition to the native protein, and suggest that the protein structure in the presence of the additive is slightly compressed compared with its state in water.	Water	247-252	lysozyme	Homo sapiens	23-31
11497570-7	2001	As examples, we first study the contributions of the partial dynamic structure factor to the generalized dynamic structure factor computed from molecular dynamics simulation of SPC/E model water.	Water	189-194	proline rich protein gene cluster	Homo sapiens	177-180
11599176-3	2001	The rate constants are 1.8 x 10(-3) M-1 sec-1, 7.2 x 10(3) M-1 sec-1, and 1.5 x 10(6) sec-1 for acid, base and water catalysis, respectively.	Water	111-116	myoregulin	Homo sapiens	36-45
11599176-3	2001	The rate constants are 1.8 x 10(-3) M-1 sec-1, 7.2 x 10(3) M-1 sec-1, and 1.5 x 10(6) sec-1 for acid, base and water catalysis, respectively.	Water	111-116	myoregulin	Homo sapiens	59-68
11375982-7	2001	Although some calpain 10 was detectable in the water-soluble protein fraction of these tissues, it was preferentially found in the water-insoluble fraction.	Water	47-52	calpain 10	Homo sapiens	14-24
11587640-5	2001	RESULTS: Here we report the high-resolution crystal structures of complexes of QR1 with three chemotherapeutic prodrugs: RH1, a water-soluble homolog of dimethylaziridinylbenzoquinone; EO9, an aziridinylindolequinone; and ARH019, another aziridinylindolequinone.	Water	128-133	NAD(P)H quinone dehydrogenase 1	Homo sapiens	79-82
11466051-3	2001	The CD intensities of the Co(III) complexes with aromatic amino acids measured in the d-d region ( approximately 20.5 x 10(3) cm(-)(1)) are significantly decreased in ethanol solutions relative to water.	Water	197-202	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	26-33
11375982-7	2001	Although some calpain 10 was detectable in the water-soluble protein fraction of these tissues, it was preferentially found in the water-insoluble fraction.	Water	131-136	calpain 10	Homo sapiens	14-24
11478250-0	2001	Reactivity of Pb(II) at the Mn(III,IV) (oxyhydr)oxide--water interface.	Water	55-60	submaxillary gland androgen regulated protein 3B	Homo sapiens	14-20
11489355-0	2001	H(2)O(2) mediates oxidative stress-induced epidermal growth factor receptor phosphorylation.	Water	0-5	epidermal growth factor receptor	Homo sapiens	43-75
11448682-1	2001	Sucrose forms a dicationic complex with cobalt(III)bis(phenanthroline) which can be isolated as the sparingly water-soluble triiodide salt or the water-soluble chloride.	Water	110-115	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	47-50
11448682-1	2001	Sucrose forms a dicationic complex with cobalt(III)bis(phenanthroline) which can be isolated as the sparingly water-soluble triiodide salt or the water-soluble chloride.	Water	146-151	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	47-50
11448682-4	2001	The 1H NMR spectrum in DMSO-d(6) shows that OH-2(g) is deprotonated and the signal of OH-1(f) is shifted strongly downfield by complexation with Co(III).	Water	44-48	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	145-152
11451441-0	2001	Structure of the YSPTSPS repeat containing two SPXX motifs in the CTD of RNA polymerase II: NMR studies of cyclic model peptides reveal that the SPTS turn is more stable than SPSY in water.	Water	183-188	CTD	Homo sapiens	66-69
11401827-2	2001	In the principal cells of the kidney collecting duct, water reabsorption is mediated by the combined action of AQP2 in the apical membrane and both AQP3 and AQP4 in the basolateral membrane, and the expression of AQP2 and AQP3 is regulated by antidiuretic hormone and water restriction.	Water	54-59	aquaporin 3	Canis lupus familiaris	148-152
11399641-10	2001	COX-2 inhibition leads to apoptosis of MICs in response to hypertonicity in vitro and after water deprivation in vivo.	Water	92-97	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
11401827-2	2001	In the principal cells of the kidney collecting duct, water reabsorption is mediated by the combined action of AQP2 in the apical membrane and both AQP3 and AQP4 in the basolateral membrane, and the expression of AQP2 and AQP3 is regulated by antidiuretic hormone and water restriction.	Water	54-59	aquaporin 3	Canis lupus familiaris	222-226
11516016-6	2001	This study also provides the protocols to assess DBP simulations in the water treatment systems.	Water	72-77	D-box binding PAR bZIP transcription factor	Homo sapiens	49-52
11287074-3	2001	In both groups, previous injections of the ANG II antagonist saralasin (Sar, 10(-10) M, 0.2 microl) into the SFO significantly attenuated the water intake caused by the ANG II injection, suggesting that the ANG II-induced drinking response may be mediated by the angiotensinergic LHA projections to the SFO.	Water	142-147	angiotensinogen	Rattus norvegicus	43-49
11287074-3	2001	In both groups, previous injections of the ANG II antagonist saralasin (Sar, 10(-10) M, 0.2 microl) into the SFO significantly attenuated the water intake caused by the ANG II injection, suggesting that the ANG II-induced drinking response may be mediated by the angiotensinergic LHA projections to the SFO.	Water	142-147	angiotensinogen	Rattus norvegicus	169-175
11431445-3	2001	Aquaporin (AQP)-1 is a hexahelical integral membrane protein that functions as a regulated channel for water and cations in fluid-secreting and -absorbing tissues.	Water	103-108	aquaporin 1 (Colton blood group)	Homo sapiens	11-17
11479740-1	2001	Catalase is an important antioxidant enzyme that detoxifies H2O2 into oxygen and water and thus limits the deleterious effects of reactive oxygen species (ROS).	Water	81-86	catalase	Homo sapiens	0-8
11447862-7	2001	This ground water probability map was then correlated with an independent set of NO2 + NO3-N data to demonstrate its effectiveness in predicting elevated NO2 + NO3-N concentrations in ground water.	Water	12-17	NBL1, DAN family BMP antagonist	Homo sapiens	160-163
11510755-5	2001	Treating Ang II-infused rats with L-NAME (75 mg/l in drinking water for 10 days, n=11) resulted in higher MAP (166+/-6 mmHg) and TPR (1.89+/-0.18 mmHg/min/ml) and lower CO (87+/-7 m/min) than untreated Ang II-infused rats.	Water	62-67	angiotensinogen	Rattus norvegicus	9-15
11435885-5	2001	Hyperoxaluria in groups 2 and 3 rats was induced by administering 1% ethylene glycol, a precursor for oxalates, in the tap water continuously throughout the whole study.	Water	123-128	nuclear RNA export factor 1	Rattus norvegicus	119-122
11433224-1	2001	VPA-985 is an orally active, competitive vasopressin V(2) receptor antagonist that in normal human beings increases water excretion without affecting solute excretion.	Water	116-121	arginine vasopressin receptor 2	Homo sapiens	41-66
11454169-0	2001	Molecular dynamics simulation of the antimicrobial salivary peptide histatin-5 in water and in trifluoroethanol: a microscopic description of the water destructuring effect.	Water	82-87	histatin 3	Homo sapiens	68-78
11454169-0	2001	Molecular dynamics simulation of the antimicrobial salivary peptide histatin-5 in water and in trifluoroethanol: a microscopic description of the water destructuring effect.	Water	146-151	histatin 3	Homo sapiens	68-78
11454169-1	2001	The results of 520 ps molecular dynamics simulation of histatin-5, a small peptide present in human saliva and possessing antimicrobial activity, dissolved in water and in 2,2,2-trifluoroethanol, are reported.	Water	159-164	histatin 3	Homo sapiens	55-65
11454169-2	2001	The simulations indicate that histatin-5 is destabilized in water and begins to unfold after 250 ps, while in organic solvent it maintains a regular secondary structure throughout the trajectory.	Water	60-65	histatin 3	Homo sapiens	30-40
11444611-1	2001	Electrochemical reduction of the iron bound in the heme group of cytochrome c is shown to occur in the nano-electrospray capillary if the protein is sprayed from neutral water using a steel wire as the electrical contact.	Water	170-175	cytochrome c, somatic	Homo sapiens	65-77
11431160-7	2001	In view of the fact that CFTR is highly expressed in pancreatic ductal cells where uroguanylin and its receptor are also localized, we assume that uroguanylin, an intrinsic pancreatic peptide, is involved in the regulation of electrolyte/water secretion in the ductal system via GC-C and CFTR.	Water	238-243	CF transmembrane conductance regulator	Homo sapiens	25-29
11479374-1	2001	Water flux across cell membranes has been shown to occur not only through the lipid bilayer, but also through aquaporins, which are members of the major intrinsic protein (MIP) super-family of channel proteins.	Water	0-5	major intrinsic protein of lens fiber	Homo sapiens	172-175
11479374-10	2001	This down-regulation of MIP gene expression may result in reduced membrane water permeability and may encourage cellular water conservation during periods of dehydration stress.	Water	75-80	major intrinsic protein of lens fiber	Homo sapiens	24-27
11479374-10	2001	This down-regulation of MIP gene expression may result in reduced membrane water permeability and may encourage cellular water conservation during periods of dehydration stress.	Water	121-126	major intrinsic protein of lens fiber	Homo sapiens	24-27
11297563-4	2001	Addition of H(2)O(2) to myoglobin (Mb), followed by catalase to quench excess H(2)O(2) before the addition of LPO, still yields LPO cross-linked products.	Water	12-17	myoglobin	Equus caballus	24-33
11575131-0	2001	[Effect of vasopressin on water permeability of epithelial cells in the kidney collecting duct during postnatal ontogenesis in rats].	Water	26-31	arginine vasopressin	Rattus norvegicus	11-22
11414818-1	2001	Catalysis of (18)O exchange between CO(2) and water catalyzed by a Co(II)-substituted mutant of human carbonic anhydrase II is analyzed to show the rate of release of H(2)(18)O from the active site.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11488456-3	2001	In the crude polysaccharide fraction (F-2) obtained by EtOH precipitation of the water extract, a significant life-prolonging effect was observed by the administration of 70 mg/kg/day.	Water	81-86	coagulation factor II	Mus musculus	38-41
11530945-10	2001	Intracerebroventricular infusion of angiotensin II caused significant increases in urine flow, electrolytes excretion, osmolar clearance, and free water reabsorption rate of both normotensive and controlled hypertensive rats.	Water	147-152	angiotensinogen	Rattus norvegicus	36-50
11297563-4	2001	Addition of H(2)O(2) to myoglobin (Mb), followed by catalase to quench excess H(2)O(2) before the addition of LPO, still yields LPO cross-linked products.	Water	78-83	myoglobin	Equus caballus	24-33
11373392-3	2001	The higher symmetry is broken mainly by the two independent water molecules in the unit cell, some reflections which would be absent in P2(1)/c having strong intensities in both the X-ray and neutron data.	Water	60-65	cyclin dependent kinase inhibitor 1A	Homo sapiens	136-141
11409751-3	2001	On the other hand, in the water-reinforced pecking task, pre-training lesions of LPO severely impaired immediate reinforcement as well as formation of the association memory.	Water	26-31	lactoperoxidase	Homo sapiens	81-84
11446632-0	2001	Pre-reactive complexes in mixtures of water vapour with halogens: characterisation of H2O...ClF and H2O...F2 by a combination of rotational spectroscopy and ab initio calculations.	Water	86-89	CLQTL1	Homo sapiens	92-95
11442298-7	2001	For example, women generally appear at higher risk than men, as do people with lower levels of education; depression is probably prodromal; head injury is an established risk factor, and may interact with the apoE gene; several occupational exposures appear hazardous, and exposure to aluminum in the water supply confers excess risk.	Water	301-306	apolipoprotein E	Homo sapiens	209-213
11446632-1	2001	Complexes H2O...ClF and H2O...F2 were detected by means of their ground-state rotational spectra in mixtures of water vapour with chlorine monofluoride and difluorine, respectively.	Water	10-13	CLQTL1	Homo sapiens	16-19
11446632-1	2001	Complexes H2O...ClF and H2O...F2 were detected by means of their ground-state rotational spectra in mixtures of water vapour with chlorine monofluoride and difluorine, respectively.	Water	112-117	CLQTL1	Homo sapiens	16-19
11446632-5	2001	Isotopic substitution showed that in each complex the H2O molecule acts as the electron donor and either CIF or F2 acts as the electron acceptor, with nuclei in the order H2O...ClF or H2O...F2.	Water	54-57	CLQTL1	Homo sapiens	177-180
11446632-6	2001	For H2O...ClF, the angle phi between the bisector of the HOH angle and the O...Cl internuclear line has the value 58.9(16)degrees, while the distance r(O...Cl)= 2.6081(23) A.	Water	4-7	CLQTL1	Homo sapiens	10-13
11446632-11	2001	The barrier at the planar C2v conformation was V0= 174cm(-1) for H2O...ClF and 7cm(-1) for H2O...F2.	Water	65-68	CLQTL1	Homo sapiens	71-74
11414046-4	2001	All of the peaks finally disappeared after 20 h. For the treated water, the transcriptional estrogenic activity in response to human estrogen receptor in a yeast hybrid assay decreased drastically to less than 1% of the initial BPA"s activity within 4 h. On the basis of these results, we conclude that TiO2 photocatalysis could be a useful technology for the purification of water containing BPA without generating any serious secondary pollution.	Water	65-70	estrogen receptor 1	Homo sapiens	133-150
11423385-0	2001	Effects of cholinergic agents on the vasopressin-mediated water transport in the isolated toad bladder.	Water	58-63	arginine vasopressin	Homo sapiens	37-48
11414046-4	2001	All of the peaks finally disappeared after 20 h. For the treated water, the transcriptional estrogenic activity in response to human estrogen receptor in a yeast hybrid assay decreased drastically to less than 1% of the initial BPA"s activity within 4 h. On the basis of these results, we conclude that TiO2 photocatalysis could be a useful technology for the purification of water containing BPA without generating any serious secondary pollution.	Water	376-381	estrogen receptor 1	Homo sapiens	133-150
11278554-4	2001	In the current study, the effect of prior water immersion stress on caerulein and tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB activation in the pancreas was evaluated.	Water	42-47	tumor necrosis factor	Rattus norvegicus	82-109
11346485-3	2001	Animals given a diet containing 2-acetylaminofluorene (2-AAF) for 12 weeks and then a basal diet and tap water containing caffeine for 18 weeks showed statistically significant decreases in the incidence, multiplicity (the number of hepatic tumors per rat) and histological grade compared with rats fed a diet containing carcinogen for 12 weeks followed by tap water alone.	Water	105-110	nuclear RNA export factor 1	Rattus norvegicus	101-104
11346485-3	2001	Animals given a diet containing 2-acetylaminofluorene (2-AAF) for 12 weeks and then a basal diet and tap water containing caffeine for 18 weeks showed statistically significant decreases in the incidence, multiplicity (the number of hepatic tumors per rat) and histological grade compared with rats fed a diet containing carcinogen for 12 weeks followed by tap water alone.	Water	105-110	nuclear RNA export factor 1	Rattus norvegicus	357-360
11346485-3	2001	Animals given a diet containing 2-acetylaminofluorene (2-AAF) for 12 weeks and then a basal diet and tap water containing caffeine for 18 weeks showed statistically significant decreases in the incidence, multiplicity (the number of hepatic tumors per rat) and histological grade compared with rats fed a diet containing carcinogen for 12 weeks followed by tap water alone.	Water	361-366	nuclear RNA export factor 1	Rattus norvegicus	101-104
11369592-0	2001	Expression and localization of the aquaporin-8 water channel in rat testis.	Water	47-52	aquaporin 8	Rattus norvegicus	35-46
11278554-4	2001	In the current study, the effect of prior water immersion stress on caerulein and tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB activation in the pancreas was evaluated.	Water	42-47	tumor necrosis factor	Rattus norvegicus	111-120
11495243-1	2001	Hydration site lifetimes of slowly diffusing water molecules at the protein/DNA interface of the vnd/NK-2 homeodomain DNA complex were determined using novel three-dimensional NMR techniques.	Water	45-50	NK2 homeobox 1	Homo sapiens	101-105
11495243-9	2001	A homology model based on the X-ray structures was created to visualize the conserved water molecules detected at the vnd/NK-2 homeodomain DNA interface.	Water	86-91	NK2 homeobox 1	Homo sapiens	122-126
11884206-0	2001	Colocalization of vasopressin and oxytocin in hypothalamic magnocellular neurons in water-deprived rats.	Water	84-89	arginine vasopressin	Rattus norvegicus	18-29
11382807-1	2001	Several aquaporin-type water channels are expressed in mammalian airways and lung: AQP1 in microvascular endothelia, AQP3 in upper airway epithelia, AQP4 in upper and lower airway epithelia, and AQP5 in alveolar epithelia.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	83-87
11382807-7	2001	Osmotic water permeability in upper airways, measured by an in vivo instillation/sample method, was reduced by approximately 40% by AQP3/AQP4 deletion.	Water	8-13	aquaporin 3	Mus musculus	132-136
11884209-6	2001	The increase of AVP and V(1b)R mRNAs in the choroid plexus further shows the involvement of AVP in the regulation of brain water content and cerebral edema.	Water	123-128	arginine vasopressin	Rattus norvegicus	16-19
11884209-6	2001	The increase of AVP and V(1b)R mRNAs in the choroid plexus further shows the involvement of AVP in the regulation of brain water content and cerebral edema.	Water	123-128	arginine vasopressin	Rattus norvegicus	92-95
11358302-8	2001	For all waters tested, DBP formation of source and corresponding reconstituted source water agreed within 95% confidence intervals.	Water	8-14	D-box binding PAR bZIP transcription factor	Homo sapiens	23-26
11358302-8	2001	For all waters tested, DBP formation of source and corresponding reconstituted source water agreed within 95% confidence intervals.	Water	8-13	D-box binding PAR bZIP transcription factor	Homo sapiens	23-26
11394288-0	2001	Investigation of water environments in a C18 bonded silica phase using 1H magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy.	Water	17-22	Bardet-Biedl syndrome 9	Homo sapiens	41-44
11410240-0	2001	Cell death by reactive oxygen species generated from water-soluble cationic metalloporphyrins as superoxide dismutase mimics.	Water	53-58	superoxide dismutase 1	Homo sapiens	97-117
11410240-1	2001	We investigated the effect on cell death of reactive oxygen species induced by water-soluble cationic metalloporphyrins with superoxide dismutase (SOD) activity.	Water	79-84	superoxide dismutase 1	Homo sapiens	125-145
11410240-1	2001	We investigated the effect on cell death of reactive oxygen species induced by water-soluble cationic metalloporphyrins with superoxide dismutase (SOD) activity.	Water	79-84	superoxide dismutase 1	Homo sapiens	147-150
11410240-6	2001	These findings suggest that FeMPy(4)P as SOD mimic converts intracellular O2(*-) to H(2)O(2) and that it rapidly reacts with H(2)O(2) to form *OH, causing DNA damage and inducing cell death.	Water	84-89	superoxide dismutase 1	Homo sapiens	41-44
11327899-1	2001	The conceptually simple mixed-valent diiron compound (NEt(4))(5)[(NC)(5)Fe(mu-tz)Fe(CN)(5)] with the 1,2,4,5-tetrazine (tz) bridging ligand was obtained as a thermally and air-stable material that displays large and highly variable electrochemical comproportionation constants between about 10(8) (in water) and 10(19.0) (in acetonitrile).	Water	301-306	tetraspanin 5	Homo sapiens	54-60
11330996-9	2001	Considering only the high-affinity site, there is a diminution in the enthalpy of binding through the series Co(II) --&gt; Zn(II) --&gt; Cu(II) that mirrors the enthalpy of hydration; this observation reinforces the notion that the thermodynamics of solute association with water is at least as important as the thermodynamics of solute-solute interaction and that these effects must be considered when interpreting association in aqueous solution.	Water	274-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
11350820-3	2001	Mice exposed to 1% ovalbumin (OVA), dissolved in the drinking water for 5 consecutive days, became unresponsive to subsequent immunogenic OVA challenges.	Water	62-67	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	19-28
11436986-11	2001	The localization of immunoreactive aquaporin-8 indicated functions for this water channel in the secretion of bile and pancreatic juice, and the secretion or absorption of water in the colon and jejunum, and the maturation or liberation of spermatogenic cells in the testis.	Water	76-81	aquaporin 8	Rattus norvegicus	35-46
11436986-11	2001	The localization of immunoreactive aquaporin-8 indicated functions for this water channel in the secretion of bile and pancreatic juice, and the secretion or absorption of water in the colon and jejunum, and the maturation or liberation of spermatogenic cells in the testis.	Water	172-177	aquaporin 8	Rattus norvegicus	35-46
11405245-11	2001	Water transport, on the other hand, was reversed from net absorption to secretion by prolactin.	Water	0-5	prolactin	Rattus norvegicus	85-94
11372825-0	2001	Application of the new C18 speedisks to the analysis of polychlorinated dibenzo-p-dioxins and dibenzofurans in water and effluent samples.	Water	111-116	Bardet-Biedl syndrome 9	Homo sapiens	23-26
11372825-1	2001	A recently introduced disk for solid-phase extraction of pollutants from water (C18 Speedisk) has been tested for the analysis of polychlorinated dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF).	Water	73-78	Bardet-Biedl syndrome 9	Homo sapiens	80-83
11386875-0	2001	Water content in an engineered dermal replacement during permeation of Me2SO solutions using rapid MR imaging.	Water	0-5	malic enzyme 2	Homo sapiens	71-74
11405245-12	2001	We propose that this prolactin-induced water secretion is probably mediated by recycling of luminal sodium in the vicinity of tight junctions.	Water	39-44	prolactin	Rattus norvegicus	21-30
11405245-0	2001	Study of acute pharmacologic effects of prolactin on calcium and water transport in the rat colon by an in vivo perfusion technique.	Water	65-70	prolactin	Rattus norvegicus	40-49
11788859-1	2001	The dynamic phase diagrams of the water-ethylene glycol (EG) system have been plotted at the warming rate of 0.4 degrees C/min(-1) after cooling of samples down to -196 degrees C by quenching in liquid nitrogen or slow cooling at the rate of approximately 0.15 degrees C/min(-1).	Water	34-39	CD59 molecule (CD59 blood group)	Homo sapiens	123-129
11405245-1	2001	We investigated the acute effect of intraperitoneally administered prolactin on calcium and water transport in colon of sexually mature female Wistar rats using an in vivo perfusion technique.	Water	92-97	prolactin	Rattus norvegicus	67-76
11405245-8	2001	The stimulatory effect of prolactin on water transport was completely abolished by reducing the perfusion rate from 1.0 mL x min(-1) to zero.	Water	39-44	prolactin	Rattus norvegicus	26-35
11405245-9	2001	The stimulatory effect of prolactin on water secretion at perfusion rate of 1.0 mL x min(-1) was also abolished when luminal [Na+] was reduced from 180 to 80 mM.	Water	39-44	prolactin	Rattus norvegicus	26-35
11975794-0	2001	Water-losing and water-retaining states: role of water channels and vasopressin receptor antagonists.	Water	0-5	arginine vasopressin	Homo sapiens	68-79
11476157-1	2001	Thioacetamide (TAA) administration (0.3 g/l of tap water for a period of 3 months) to rats resulted in hepatic cirrhosis as assessed by biochemical and histopathological findings.	Water	51-56	nuclear RNA export factor 1	Rattus norvegicus	47-50
11316770-8	2001	We therefore examined the effect of water immersion-restraint stress on c-Fos protein accumulation in PrRP- and TH-immunoreactive neurons.	Water	36-41	prolactin releasing hormone	Homo sapiens	102-106
11291067-5	2001	Catalase and bathocuproine inhibited the DNA damage, suggesting the involvement of H(2)O(2) and Cu(I).	Water	83-88	catalase	Homo sapiens	0-8
11368594-7	2001	Calcium salts and GDL-treated SPI films had lower water-vapor permeability than the SPI control film.	Water	50-55	chromogranin A	Homo sapiens	30-33
11292726-0	2001	Reversal of the CD4(+)/CD8(+) T-cell ratio in lymph node cells upon in vitro mitogenic stimulation by highly purified, water-soluble S3-S4 dimer of pertussis toxin.	Water	119-124	CD4 molecule	Homo sapiens	16-19
11401257-6	2001	The NO3-N concentrations fluctuated between 5 mg L(-1) at deep ground water levels and 15 mg L(-1) at shallow levels, due to variations in water flow.	Water	139-144	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
11401257-3	2001	A new flow-proportional drainage water sampling method for submerged drains has been developed to monitor NO3-N leaching.	Water	33-38	NBL1, DAN family BMP antagonist	Homo sapiens	106-109
11401257-7	2001	A flow-proportional drainage water sampling method is required to measure NO3-N leaching accurately under these conditions.	Water	29-34	NBL1, DAN family BMP antagonist	Homo sapiens	74-77
11401257-8	2001	Errors of up to 43% may occur when NO3-N concentrations in the drainage water are only measured at intervals of 30 d and when the precipitation excess is used to estimate cumulative NO3-N leaching.	Water	72-77	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
11351513-8	2001	It appears likely that spatially and temporally dynamic redox zonation at the plume transect will prevent future sustained reductive dehalogenation of highly chlorinated solvents, for during the course of a year, the predominant TEAP at the highly contaminated water table shifted from methanogenesis to iron- and sulfate-reduction.	Water	261-266	tumor protein p53 inducible nuclear protein 1	Homo sapiens	229-233
11401257-9	2001	Measurements of NO3-N concentrations in ground water cannot be used to accurately estimate NO3-N leaching in drained soils.	Water	47-52	NBL1, DAN family BMP antagonist	Homo sapiens	16-19
11499339-5	2001	RESULTS: Under 2.5 atm HBO status, the PO2 of UROCITRA solution was 365 +/- 44 mmHg, which was significantly higher than that of tap water (113 +/- 62 mmHg) and UROCITRA solution (125 +/- 12 mmHg) under normobaric condition (p &lt; 0.001).	Water	133-138	SEC14 like lipid binding 2	Homo sapiens	129-132
11323456-1	2001	PURPOSE: To describe the changes in brain water diffusibility in five anatomic locations in children with neurofibromatosis type 1 (NF 1) compared with these changes in control subjects and to describe the water diffusibility changes associated with hyperintense basal ganglia lesions in children with NF 1.	Water	42-47	neurofibromin 1	Homo sapiens	106-130
11323456-1	2001	PURPOSE: To describe the changes in brain water diffusibility in five anatomic locations in children with neurofibromatosis type 1 (NF 1) compared with these changes in control subjects and to describe the water diffusibility changes associated with hyperintense basal ganglia lesions in children with NF 1.	Water	42-47	neurofibromin 1	Homo sapiens	132-136
11335105-1	2001	Channels of the major intrinsic protein (MIP) of the lens transport water, thus playing an important role in lens fiber cell homeostasis.	Water	68-73	major intrinsic protein of lens fiber	Homo sapiens	41-44
11312289-0	2001	A novel role of vasopressin in the brain: modulation of activity-dependent water flux in the neocortex.	Water	75-80	arginine vasopressin	Homo sapiens	16-27
11312289-3	2001	Because vasopressin is known to regulate aquaporin expression and translocation in kidney collecting ducts and thereby control water reabsorption, we hypothesized that vasopressin might serve a similar function in the brain.	Water	127-132	arginine vasopressin	Homo sapiens	8-19
11312289-9	2001	These data suggest that vasopressin and V1a receptors play a crucial role in the regulation of brain water and ion homeostasis, most probably by modulating aquaporin-mediated water flux through astrocyte plasma membranes.	Water	101-106	arginine vasopressin	Homo sapiens	24-35
11312289-9	2001	These data suggest that vasopressin and V1a receptors play a crucial role in the regulation of brain water and ion homeostasis, most probably by modulating aquaporin-mediated water flux through astrocyte plasma membranes.	Water	175-180	arginine vasopressin	Homo sapiens	24-35
11319714-13	2001	In conclusion, within 1 to 3 months, GH therapy accelerates lean tissue accrual, especially the water and protein components, but has a smaller effect on reducing fat mass.	Water	96-101	growth hormone 1	Homo sapiens	37-39
11320486-1	2001	The discovery of aquaporin-1 (AQP1) by Agre and associates answered the longstanding biophysical question of how water specifically crosses biological membranes.	Water	113-118	aquaporin 1 (Colton blood group)	Homo sapiens	17-28
11320486-1	2001	The discovery of aquaporin-1 (AQP1) by Agre and associates answered the longstanding biophysical question of how water specifically crosses biological membranes.	Water	113-118	aquaporin 1 (Colton blood group)	Homo sapiens	30-34
11329675-6	2001	Significant DMTS production also occurred with Wanneroo water that contained added omega-thio-containing compounds such as cysteine (1400 ng L-1 DMTS), and 3-mercaptopropionate (210 ng L-1).	Water	56-61	immunoglobulin kappa variable 1-16	Homo sapiens	141-144
11329675-6	2001	Significant DMTS production also occurred with Wanneroo water that contained added omega-thio-containing compounds such as cysteine (1400 ng L-1 DMTS), and 3-mercaptopropionate (210 ng L-1).	Water	56-61	immunoglobulin kappa variable 1-16	Homo sapiens	185-188
11331298-5	2001	Furthermore, H(2)O(2-) or UV-stimulated SAPK activity was higher in mouse embryonic fibroblast (MEF) cells from PS1-null mice than in MEF cells from PS(+/+) mice.	Water	13-18	mitogen-activated protein kinase 9	Homo sapiens	40-44
12528518-2	2001	METHOD: A RP-HPLC method was set up, using Hypersil-18 column, acetonitrile: water(30:70) as mobile phase with a flow rate of 0.8 ml.min-1.	Water	77-82	CD59 molecule (CD59 blood group)	Homo sapiens	133-138
11278590-4	2001	Presumably, colipase functions by anchoring and orienting PTL at the oil-water interface.	Water	73-78	colipase	Homo sapiens	12-20
11278901-0	2001	Roles of water in heme peroxidase and catalase mechanisms.	Water	9-14	catalase	Homo sapiens	38-46
11231042-0	2001	Atypical angiotensin receptors may mediate water intake induced by central injections of angiotensin II and of serotonin in pigeons.	Water	43-48	angiotensinogen	Homo sapiens	89-103
11231042-9	2001	At the doses presently used both 5-HT and ANGII treatments evoked comparable water intake amounts with similar behavioral profiles.	Water	77-82	angiotensinogen	Homo sapiens	42-47
11231042-10	2001	While pretreatment with SAR dose-dependently reduced the water intake evoked by both 5-HT and ANGII, neither losartan nor PD 123,319 pretreatment affected the drinking induced by these treatments.	Water	57-62	angiotensinogen	Homo sapiens	94-99
11278499-2	2001	Recently, it has been reported that mRNA for the water channel, aquaporin-8 (AQP8), is present in hepatocytes.	Water	49-54	aquaporin 8	Rattus norvegicus	64-75
11349907-3	2001	From the mechanistic point of view the reaction is found to be similar to a SN2 mechanism and coupled with water-mediated proton transfer in accordance with the intriguing findings of Bianco and Hynes [R. Bianco, J. T. Hynes.	Water	107-112	solute carrier family 38 member 5	Homo sapiens	76-79
11278499-2	2001	Recently, it has been reported that mRNA for the water channel, aquaporin-8 (AQP8), is present in hepatocytes.	Water	49-54	aquaporin 8	Rattus norvegicus	77-81
11246949-8	2001	When H2O is added prior to pressing, the DCPA produced reacts with the remaining TetCP forming HAp.	Water	5-8	BAG cochaperone 1	Homo sapiens	95-98
11124966-3	2001	In addition, water-mediated interactions replace the hydrogen bonding interactions between the N(6) of anti-cAMP bound in the N-terminal domains of each subunit and the OH groups of the Thr(127) and Ser(128) residues in the C alpha-helix of wild type CRP.	Water	13-18	C-reactive protein	Homo sapiens	251-254
11795517-5	2001	As a result, both water and methanol extracts were found to cause not only significant increases in rat liver cytosolic SOD, catalase, and GSEH-px activities, but also a significant decrease in MDA production in TBA reactant assay in rats.	Water	18-23	catalase	Rattus norvegicus	125-133
11795518-10	2001	Expressions of TNF-alpha and IL-6 were inhibited in the lungs of these mice after treatment with green tea in drinking water for 4 months.	Water	119-124	tumor necrosis factor	Mus musculus	15-24
11795518-10	2001	Expressions of TNF-alpha and IL-6 were inhibited in the lungs of these mice after treatment with green tea in drinking water for 4 months.	Water	119-124	interleukin 6	Mus musculus	29-33
11457013-1	2001	A 7.6 ns molecular dynamics trajectory of the betaARK1 PH domain in explicit water with appropriate ions was calculated at 300 K. Spectral densities at omega = 0, omega(N), and 0.87omega(H) and the model-free parameters were evaluated from the experimental as well as the simulated data, taking the anisotropic overall motion of the protein into account.	Water	77-82	G protein-coupled receptor kinase 2	Homo sapiens	46-54
28091051-2	2001	The RCN is to be congratulated for supporting water fluoridation in its manifesto (letters March 14).	Water	46-51	reticulocalbin 1	Homo sapiens	4-7
11482452-2	2001	Original water extracts from mycelia (Fraction A-0) and fruiting bodies (Fraction B-0) induced TNF-alpha secretion by macrophages derived from rat bone marrow.	Water	9-14	tumor necrosis factor	Rattus norvegicus	95-104
11403985-0	2001	Role of the alpha(1)- and alpha(2)-adrenoceptors of the paraventricular nucleus on the water and salt intake, renal excretion, and arterial pressure induced by angiotensin II injection into the medial septal area.	Water	87-92	angiotensinogen	Homo sapiens	160-174
11403985-2	2001	ANG II injection into the MSA induced water and sodium intake, diuresis, natriuresis, and pressor responses.	Water	38-43	angiotensinogen	Homo sapiens	0-6
11403985-4	2001	Previous injection of a nonselective alpha-adrenergic antagonist, regitin, into the PVN blocked the urinary excretion, and reduced the water and sodium intake, sodium intake, and pressor responses induced by ANG II injected into the MSA.	Water	135-140	angiotensinogen	Homo sapiens	208-214
11309250-7	2001	The second component (4 - 5 h) of the oxLDL-induced EGFR activation is antioxidant-sensitive, since it is blocked by antioxidants such as trolox, caffeic acid or PDTC, which act by blocking the cellular oxidative stress (H(2)O(2) generation) evoked by oxLDL.	Water	221-226	epidermal growth factor receptor	Homo sapiens	52-56
11371070-1	2001	Co(III) hexamethylenedithiocarbamate has been applied as a collector in colloid flotation preconcentration of Cd from water prior to electrothermal atomic absorption spectrometry (ETAAS).	Water	118-123	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	0-7
11566011-3	2001	It selectively prevents vasopressin-dependent water resorption, increasing water excretion with low electrolyte loss [266993] and is selective towards the human V2 versus V1 receptors [295987].	Water	46-51	arginine vasopressin	Homo sapiens	24-35
11411093-4	2001	Five days after water deprivation, AVP and NKB immunoreactivity decreased drastically, while NKBp-immunoreactivity increased in both the PVN and SON magnocellular neurons.	Water	16-21	arginine vasopressin	Rattus norvegicus	35-38
11411093-7	2001	After five days of water deprivation, AVP mRNA in the PVN and NKB mRNA in both the PVN and the SON increased considerably.	Water	19-24	arginine vasopressin	Rattus norvegicus	38-41
11348089-5	2001	The optimized gas and water flow rates were approximately 1.2 and approximately 14 mL min(-1), respectively, giving a response time of less than 15 min and a CO-extraction yield of approximately 80%.	Water	22-27	CD59 molecule (CD59 blood group)	Homo sapiens	86-92
11411093-8	2001	These results indicate that synthesis and release of NKB, which colocalizes to AVP neurons, are enhanced by water deprivation in the same manner as AVP in the PVN and SON.	Water	108-113	arginine vasopressin	Rattus norvegicus	79-82
11170215-0	2001	Dynamics of internal water in fatty acid binding protein: computer simulations and comparison with experiments.	Water	21-26	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	30-56
11358674-1	2001	Growth hormone (GH) treatment causes salt and water retention, and this effect has been suggested to be mediated by activation of epithelial sodium channel (ENaC).	Water	46-51	growth hormone 1	Homo sapiens	0-14
11358674-1	2001	Growth hormone (GH) treatment causes salt and water retention, and this effect has been suggested to be mediated by activation of epithelial sodium channel (ENaC).	Water	46-51	growth hormone 1	Homo sapiens	16-18
11349819-3	2001	Particular emphasis is placed on: (1) demonstrating the relationship between the total empirical HINT score and free energy of association, deltaGinteraction; (2) showing that the HINT hydrophobic-polar interaction sub-score represents the energy cost of desolvation upon binding for interacting biomolecules; and (3) a new methodology for treating constrained water molecules as discrete independent small ligands.	Water	361-366	histidine triad nucleotide binding protein 1	Homo sapiens	97-101
11349819-3	2001	Particular emphasis is placed on: (1) demonstrating the relationship between the total empirical HINT score and free energy of association, deltaGinteraction; (2) showing that the HINT hydrophobic-polar interaction sub-score represents the energy cost of desolvation upon binding for interacting biomolecules; and (3) a new methodology for treating constrained water molecules as discrete independent small ligands.	Water	361-366	histidine triad nucleotide binding protein 1	Homo sapiens	180-184
11316437-3	2001	The labels are visualized in situ by differently colored water-insoluble precipitates using alkaline phosphatase- or beta-galactosidase-based immunoassays.	Water	57-62	Alkaline phosphatase 4	Drosophila melanogaster	92-112
11259763-1	2001	Angiotensin II (ANG-II) and atrial natriuretic peptide (ANP) have opposing actions on water and salt intake and excretion.	Water	86-91	angiotensinogen	Homo sapiens	0-14
11118442-9	2001	Moreover, the inhibition of NF-kappaB nuclear translocation by NO donors directly correlated with the intracellular concentration of H(2)O(2) and was reversed by the addition of exogenous H(2)O(2).	Water	133-138	nuclear factor kappa B subunit 1	Homo sapiens	28-37
11259763-5	2001	Injection of ANG-II (12.5 ng) into the anteroventral region of the third ventricle (AV3V) at the effective dose to increase water intake increased plasma ANP concentrations (P&lt;0.01) within 5 min.	Water	124-129	angiotensinogen	Homo sapiens	13-19
11274397-5	2001	USA 93, 13367--13370] that SGLT1, the high affinity intestinal and renal sodium/glucose cotransporter carries water molecules along with the cosubstrates with a strict stoichiometry of two Na(+), one glucose, and approximately 220 water molecules per transport cycle.	Water	110-115	solute carrier family 5 member 1	Homo sapiens	27-32
11274397-5	2001	USA 93, 13367--13370] that SGLT1, the high affinity intestinal and renal sodium/glucose cotransporter carries water molecules along with the cosubstrates with a strict stoichiometry of two Na(+), one glucose, and approximately 220 water molecules per transport cycle.	Water	231-236	solute carrier family 5 member 1	Homo sapiens	27-32
11274397-7	2001	The osmotic water permeability of oocytes expressing human SGLT1 (L(p) +/- SE) averaged 3.8 +/- 0.3 x 10(-4) cm x s(-1) (n = 15) and addition of 100 microM phlorizin (a specific SGLT1 inhibitor) reduced the permeability to 2.2 +/- 0.2 x 10(-4) cm x s(-1) (n = 15), confirming the presence of a significant water permeability closely associated with the cotransporter.	Water	12-17	solute carrier family 5 member 1	Homo sapiens	59-64
11274397-12	2001	It is concluded that, in SGLT1-expressing oocytes, alpha MG-dependent water influx is induced by a local osmotic gradient by using both endogenous and SGLT1-dependent water permeability.	Water	70-75	solute carrier family 5 member 1	Homo sapiens	25-30
11274397-12	2001	It is concluded that, in SGLT1-expressing oocytes, alpha MG-dependent water influx is induced by a local osmotic gradient by using both endogenous and SGLT1-dependent water permeability.	Water	70-75	solute carrier family 5 member 1	Homo sapiens	151-156
11274397-12	2001	It is concluded that, in SGLT1-expressing oocytes, alpha MG-dependent water influx is induced by a local osmotic gradient by using both endogenous and SGLT1-dependent water permeability.	Water	167-172	solute carrier family 5 member 1	Homo sapiens	151-156
11254388-0	2001	Core and surface mutations affect folding kinetics, stability and cooperativity in IL-1 beta: does alteration in buried water play a role?	Water	120-125	interleukin 1 beta	Homo sapiens	83-92
11259763-6	2001	As described before, previous injection of phenylephrine (an alpha(1)-adrenergic agonist) or clonidine (an alpha(2)-adrenergic agonist) into the AV3V region significantly reduced ANG-II-induced water intake.	Water	194-199	angiotensinogen	Homo sapiens	179-185
11259763-8	2001	These results suggest that the inhibitory effect of both alpha-adrenergic agonists on ANG-II-induced water intake can be explained, at least in part, by the increase in ANP content and presumed release from these neural structures.	Water	101-106	angiotensinogen	Homo sapiens	86-92
11259763-8	2001	These results suggest that the inhibitory effect of both alpha-adrenergic agonists on ANG-II-induced water intake can be explained, at least in part, by the increase in ANP content and presumed release from these neural structures.	Water	101-106	natriuretic peptide A	Homo sapiens	169-172
11259772-11	2001	The water contents in the ipsilateral basal ganglia 24 h after infusion of thrombin five units were 82.6+/-0.8%, 79.2+/-0.4% and 81.8+/-1.9% in the control, TPC alone and TPC plus PD 098059 groups, respectively.	Water	4-9	coagulation factor II	Rattus norvegicus	75-83
11259763-1	2001	Angiotensin II (ANG-II) and atrial natriuretic peptide (ANP) have opposing actions on water and salt intake and excretion.	Water	86-91	angiotensinogen	Homo sapiens	16-22
11259763-1	2001	Angiotensin II (ANG-II) and atrial natriuretic peptide (ANP) have opposing actions on water and salt intake and excretion.	Water	86-91	natriuretic peptide A	Homo sapiens	28-54
11259763-1	2001	Angiotensin II (ANG-II) and atrial natriuretic peptide (ANP) have opposing actions on water and salt intake and excretion.	Water	86-91	natriuretic peptide A	Homo sapiens	56-59
11245904-2	2001	Antioxidant enzymes, superoxide dismutases (SOD, converting superoxide anion into H2O2) and catalase (converting H2O2 into water), are candidate drugs for augmentation of antioxidant defenses in endothelium.	Water	123-128	superoxide dismutase 1	Homo sapiens	44-47
11267655-11	2001	Our findings suggest that two promoters regulate transcription of the four UT-A isoforms, and that stimulation of transcription by vasopressin, mediated by cAMP and CRE sequences, and controlled by an intronic promoter, may contribute to the increase in UT-A2 expression during water deprivation.	Water	278-283	arginine vasopressin	Rattus norvegicus	131-142
11251046-5	2001	SGLT1 has two modes of water transport.	Water	23-28	solute carrier family 5 member 1	Homo sapiens	0-5
11251046-6	2001	First, it acts as a molecular water pump: for each 2 Na+ and 1 sugar molecule 264 water molecules were cotransported in the human SGLT1 (hSGLT1), 424 for the rabbit SGLT1 (rSGLT1).	Water	30-35	solute carrier family 5 member 1	Homo sapiens	130-135
11251046-6	2001	First, it acts as a molecular water pump: for each 2 Na+ and 1 sugar molecule 264 water molecules were cotransported in the human SGLT1 (hSGLT1), 424 for the rabbit SGLT1 (rSGLT1).	Water	30-35	solute carrier family 5 member 1	Homo sapiens	137-143
11251046-6	2001	First, it acts as a molecular water pump: for each 2 Na+ and 1 sugar molecule 264 water molecules were cotransported in the human SGLT1 (hSGLT1), 424 for the rabbit SGLT1 (rSGLT1).	Water	30-35	solute carrier family 5 member 1	Homo sapiens	138-143
11251046-6	2001	First, it acts as a molecular water pump: for each 2 Na+ and 1 sugar molecule 264 water molecules were cotransported in the human SGLT1 (hSGLT1), 424 for the rabbit SGLT1 (rSGLT1).	Water	82-87	solute carrier family 5 member 1	Homo sapiens	130-135
11251046-6	2001	First, it acts as a molecular water pump: for each 2 Na+ and 1 sugar molecule 264 water molecules were cotransported in the human SGLT1 (hSGLT1), 424 for the rabbit SGLT1 (rSGLT1).	Water	82-87	solute carrier family 5 member 1	Homo sapiens	137-143
11251046-6	2001	First, it acts as a molecular water pump: for each 2 Na+ and 1 sugar molecule 264 water molecules were cotransported in the human SGLT1 (hSGLT1), 424 for the rabbit SGLT1 (rSGLT1).	Water	82-87	solute carrier family 5 member 1	Homo sapiens	138-143
11251046-15	2001	With the given expression levels, the steady state water transport was divided about equally between cotransport, osmosis across the SGLT1 and osmosis across the native oocyte membrane.	Water	51-56	solute carrier family 5 member 1	Homo sapiens	133-138
11251046-17	2001	Coexpression of AQP1 with the SGLT1 increased the water permeability more than 10-fold and steady state isotonic transport was achieved after less than 2 s of sugar activation.	Water	50-55	aquaporin 1 (Colton blood group)	Homo sapiens	16-20
11251046-17	2001	Coexpression of AQP1 with the SGLT1 increased the water permeability more than 10-fold and steady state isotonic transport was achieved after less than 2 s of sugar activation.	Water	50-55	solute carrier family 5 member 1	Homo sapiens	30-35
11251046-20	2001	The data suggest that SGLT1 has three roles in isotonic water transport: it cotransports water directly, it supplies a passive pathway for osmotic water transport, and it generates an osmotic driving force that can be employed by other pathways, for example aquaporins.	Water	56-61	solute carrier family 5 member 1	Homo sapiens	22-27
11251046-20	2001	The data suggest that SGLT1 has three roles in isotonic water transport: it cotransports water directly, it supplies a passive pathway for osmotic water transport, and it generates an osmotic driving force that can be employed by other pathways, for example aquaporins.	Water	89-94	solute carrier family 5 member 1	Homo sapiens	22-27
11251046-20	2001	The data suggest that SGLT1 has three roles in isotonic water transport: it cotransports water directly, it supplies a passive pathway for osmotic water transport, and it generates an osmotic driving force that can be employed by other pathways, for example aquaporins.	Water	89-94	solute carrier family 5 member 1	Homo sapiens	22-27
11258916-4	2001	The 1.65 A crystal structure of Mss4 reveals a network of direct and water-mediated interactions that stabilize a partially exposed structural subdomain derived from four highly conserved but nonconsecutive sequence elements.	Water	69-74	RAB interacting factor	Homo sapiens	32-36
11245904-2	2001	Antioxidant enzymes, superoxide dismutases (SOD, converting superoxide anion into H2O2) and catalase (converting H2O2 into water), are candidate drugs for augmentation of antioxidant defenses in endothelium.	Water	123-128	catalase	Homo sapiens	92-100
11396161-1	2001	BACKGROUND: VIP acts as a neuroendocrine mediator under physiological conditions, with an important role in water and electrolyte secretion in the gut.	Water	108-113	vasoactive intestinal peptide	Homo sapiens	12-15
11245926-1	2001	In order to identify cell surface proteins that interact with the amyloid precursor protein (APP), we biotinylated H4 human neuroglioma cells in culture with a water soluble biotinylating agent, immunoprecipitated APP with an antibody specific to the intracellular domain, and probed the precipitated proteins with anti-biotin.	Water	160-165	amyloid beta precursor protein	Homo sapiens	66-91
11245926-5	2001	Interaction of APP and LRP on the surface of living cells was demonstrated by crosslinking APP and LRP with the water-soluble cross-linking agent BS(3).	Water	112-117	LDL receptor related protein 1	Homo sapiens	23-26
11245926-5	2001	Interaction of APP and LRP on the surface of living cells was demonstrated by crosslinking APP and LRP with the water-soluble cross-linking agent BS(3).	Water	112-117	LDL receptor related protein 1	Homo sapiens	99-102
11254529-5	2001	We found that both LPS and ventilation with -25 cm H2O (overventilation; OV) caused translocation of NF-kappaB, which was abolished by pretreatment with the steroid dexamethasone.	Water	51-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
11289956-1	2001	The conductance of sodium ions through a simplified channel-membrane system immersed in a reservoir of 1M NaCl in SPC/E water is examined by molecular dynamics simulation.	Water	120-125	proline rich protein gene cluster	Homo sapiens	114-117
11300810-1	2001	(1/2)H2O and in the spin crossover complexes [Co(II)(terpy)2]X2.nH2O (X = Cl and ClO4): a Mossbauer emission spectroscopic study.	Water	5-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
11248229-0	2001	Molecular organization of the human serotonin transporter at the air/water interface.	Water	69-74	solute carrier family 6 member 4	Homo sapiens	36-57
11357353-1	2001	The effect of bidistilled modified water obtained by treating bidistilled water with static electric field in the cathode compartment of a diaphragm electrolyzer on the production of tumor necrosis factor and activity of natural killer cells of mice was studied.	Water	35-40	tumor necrosis factor	Mus musculus	183-204
11259078-7	2001	The Ad5mIL6 infection (known to induce excessive IL-6 levels over five days) transiently reduced food, water, and sucrose intake, as well as rectal temperature in MRL +/+ and AKR/J mice.	Water	103-108	interleukin 6	Mus musculus	49-53
11441521-1	2001	Angiotensin II plays an important role in blood pressure control and in water and salt homeosthasis.	Water	72-77	angiotensinogen	Homo sapiens	0-14
11357353-1	2001	The effect of bidistilled modified water obtained by treating bidistilled water with static electric field in the cathode compartment of a diaphragm electrolyzer on the production of tumor necrosis factor and activity of natural killer cells of mice was studied.	Water	74-79	tumor necrosis factor	Mus musculus	183-204
11357353-2	2001	It was found that bidistilled modified water added to cultured murine macrophages increases the tumor necrosis factor production 2.5-3-fold.	Water	39-44	tumor necrosis factor	Mus musculus	96-117
11357353-3	2001	A similar degree of stimulation of tumor necrosis factor production was observed after peroral administration of bidistilled modified water for 10-25 days.	Water	134-139	tumor necrosis factor	Mus musculus	35-56
11269608-8	2001	In the second and third trimesters of pregnancy, insulin requirements were inversely associated with total, water soluble, and insoluble fiber intakes; the correlation coefficients ranged from -0.22 to -0.17 (P=.02 to .08).	Water	108-113	insulin	Homo sapiens	49-56
11237445-1	2001	We investigated the As(III) and As(V) adsorption complexes forming at the gamma-Al(2)O(3)/water interface as a function of pH and ionic strength (I), using a combination of adsorption envelopes, electrophoretic mobility (EM) measurements, and X-ray absorption spectroscopy (XAS).	Water	90-95	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	32-37
11277716-2	2001	From a previous reported density function for lysozyme in water a simulated spectrum, without the superposition of statistical fluctuation and spectrometer resolution effects, was generated.	Water	58-63	lysozyme	Homo sapiens	46-54
11226886-12	2001	Based on the generally accepted catalytic mechanism for serine protease, we propose that a water molecule located at the catalytic site plays an important role in blocking the catalytic function of the reactive Ser193 OH group.	Water	91-96	coagulation factor II, thrombin	Homo sapiens	56-71
11239067-2	2001	At least two molecules might be involved in UF failure: aquaporin-1 (AQP1), a water channel thought to be the ultra small pore of the peritoneal membrane (PM), and nitric oxide (NO), which might regulate effective peritoneal surface area and microvascular permeability.	Water	78-83	aquaporin 1 (Colton blood group)	Homo sapiens	56-67
11325026-1	2001	Water extract from commercial English tea has a potent inhibitory activity against human placenta aldose reductase (NADPH oxidoreductase, E.C.1.1.1.21.).	Water	0-5	aldo-keto reductase family 1 member B	Homo sapiens	98-114
11239067-5	2001	RESULTS: AQP1 is located in the endothelium lining peritoneal capillaries, and its expression is remarkably stable in samples ranging from normal to highly inflamed peritoneum and even when transcellular water permeability is absent (loss of sodium sieving).	Water	204-209	aquaporin 1 (Colton blood group)	Homo sapiens	9-13
11321952-1	2001	The feasible methods for oxidation and removal of arsenite[As(III)] from dispersed drinking water were based on the removal of arsenate[As(V)] by ferric sulfate.	Water	92-97	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	136-141
11287109-7	2001	The NPY antagonist D-NPY partially reduced ethanol self-administration and completely blocked the effects of an intermediate dose of NPY (10 fmol) on ethanol intake, preference, and water intake.	Water	182-187	neuropeptide Y	Rattus norvegicus	4-7
11287109-7	2001	The NPY antagonist D-NPY partially reduced ethanol self-administration and completely blocked the effects of an intermediate dose of NPY (10 fmol) on ethanol intake, preference, and water intake.	Water	182-187	neuropeptide Y	Rattus norvegicus	21-24
11287109-7	2001	The NPY antagonist D-NPY partially reduced ethanol self-administration and completely blocked the effects of an intermediate dose of NPY (10 fmol) on ethanol intake, preference, and water intake.	Water	182-187	neuropeptide Y	Rattus norvegicus	21-24
11287109-6	2001	All doses of NPY significantly increased ethanol self-administration and preference, and decreased water intake.	Water	99-104	neuropeptide Y	Rattus norvegicus	13-16
11321952-2	2001	The results showed that the spotaneous oxidation of As(III) to As(V) was very slow and could not be enhanced by aerating for 24 h. The removal rate of As(III) could reach that of As(V) when pre-aerating water samples with ozone for 60 s, putting 7.5 ml/L hydrogen peroxide solution, adding 2.5 mg/L javelle water (sodium hypochlorite) or 15 mg/L bleaching powder(numerated by chlorine).	Water	203-208	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	63-68
11321952-2	2001	The results showed that the spotaneous oxidation of As(III) to As(V) was very slow and could not be enhanced by aerating for 24 h. The removal rate of As(III) could reach that of As(V) when pre-aerating water samples with ozone for 60 s, putting 7.5 ml/L hydrogen peroxide solution, adding 2.5 mg/L javelle water (sodium hypochlorite) or 15 mg/L bleaching powder(numerated by chlorine).	Water	203-208	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	179-184
11321952-2	2001	The results showed that the spotaneous oxidation of As(III) to As(V) was very slow and could not be enhanced by aerating for 24 h. The removal rate of As(III) could reach that of As(V) when pre-aerating water samples with ozone for 60 s, putting 7.5 ml/L hydrogen peroxide solution, adding 2.5 mg/L javelle water (sodium hypochlorite) or 15 mg/L bleaching powder(numerated by chlorine).	Water	307-312	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	63-68
11321952-2	2001	The results showed that the spotaneous oxidation of As(III) to As(V) was very slow and could not be enhanced by aerating for 24 h. The removal rate of As(III) could reach that of As(V) when pre-aerating water samples with ozone for 60 s, putting 7.5 ml/L hydrogen peroxide solution, adding 2.5 mg/L javelle water (sodium hypochlorite) or 15 mg/L bleaching powder(numerated by chlorine).	Water	307-312	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	179-184
11321952-3	2001	The oxidation by using javelle water was rather stable when samples were varied in pH value, hardness, initial concentration of As(III) and As(III)/As(V) ratio.	Water	31-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	148-153
11456705-4	2001	This similarity is consistent with the presence of two axial ligands to the heme iron within the PS2.M--hemin complex, one of which is a water molecule.	Water	137-142	taste 2 receptor member 64 pseudogene	Homo sapiens	97-100
11329272-7	2001	Eosinophil peroxidase required H(2)O(2) and Br(-) to produce 5-bromouracil, implicating HOBr as an intermediate in the reaction.	Water	31-36	eosinophil peroxidase	Homo sapiens	0-21
11456705-6	2001	Low-temperature EPR analysis coupled with parallel spin-trapping investigations following the reaction of the PS2.M--hemin complex and hydrogen peroxide (H(2)O(2)) indicated the formation of a carbon-centered radical, most likely on the PS2.M oligonucleotide.	Water	154-159	taste 2 receptor member 64 pseudogene	Homo sapiens	110-113
11250200-5	2001	The structure of this 1:1 complex was determined and the hormone-receptor interface shown to be characterized by a number of hydrophilic interactions mediated by several highly ordered water networks.	Water	185-190	nuclear receptor subfamily 4 group A member 1	Homo sapiens	57-73
11171962-1	2001	The water-selective pathway through the aquaporin-1 membrane channel has been visualized by fitting an atomic model to a 3.7-A resolution three-dimensional density map.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	40-51
11162114-0	2001	Water and ion binding around r(UpA)12 and d(TpA)12 oligomers--comparison with RNA and DNA (CpG)12 duplexes.	Water	0-5	proline rich acidic protein 1	Homo sapiens	31-34
11076939-0	2001	Assembly and ligand binding properties of the water-soluble extracellular domains of the glutamate receptor 1 subunit.	Water	46-51	glutamate receptor 1	Xenopus laevis	89-109
11162114-1	2001	The structural and dynamic properties of the water and ion first coordination shell of the r(A-U) and d(A-T) base-pairs embedded within the r(UpA)12 and d(TpA)12 duplexes are described on the basis of two 2.4 ns molecular dynamics simulations performed in a neutralizing aqueous environment with 0.25 M added KCl.	Water	45-50	proline rich acidic protein 1	Homo sapiens	142-145
11310508-1	2001	The aquaporin (AQP)-9 gene was recently isolated from human and rat liver cDNA libraries as a member of the water channel family for water and neutral solutes.	Water	108-113	aquaporin 9	Homo sapiens	4-21
11310508-1	2001	The aquaporin (AQP)-9 gene was recently isolated from human and rat liver cDNA libraries as a member of the water channel family for water and neutral solutes.	Water	133-138	aquaporin 9	Homo sapiens	4-21
11310508-10	2001	These findings suggest a specific role for AQP9 in the transport of water and non-charged solutes in hepatocytes and Leydig cells.	Water	68-73	aquaporin 9	Rattus norvegicus	43-47
11157876-2	2001	CO(2) permeability (P:CO(2)) measurements in an oocyte expression system and in reconstituted proteoliposomes have suggested that the water channel AQP1 can transport CO(2).	Water	134-139	aquaporin 1	Bos taurus	148-152
11308026-1	2001	Acid sphingomyelinase is a water-soluble, lysosomal glycoprotein that catalyzes the degradation of membrane-bound sphingomyelin into phosphorylcholine and ceramide.	Water	27-32	sphingomyelin phosphodiesterase 1	Homo sapiens	0-21
11158210-8	2001	The water-loaded rats were hyponatremic (plasma Na+, 98 to 122 mmol/L) and manifested the expected early natriuresis and diuresis of vasopressin escape.	Water	4-9	arginine vasopressin	Rattus norvegicus	133-144
11158210-13	2001	These data suggest that several distal sodium reabsorptive mechanisms are upregulated during vasopressin escape; this may help to attenuate the developing hyponatremia resulting from water loading when vasopressin levels are inappropriately elevated.	Water	183-188	arginine vasopressin	Rattus norvegicus	93-104
11289406-9	2001	VEGF may be the factor that enhances the hepatic mass with water-soluble iodinated contrast agent in CT.	Water	59-64	vascular endothelial growth factor A	Homo sapiens	0-4
11253018-2	2001	A study with polychlorinated biphenyls (PCBs) found that diurnal PCB air/water exchange rates exceeded nocturnal exchange rates by 32%.	Water	73-78	pyruvate carboxylase	Homo sapiens	40-43
11253018-3	2001	Given that the exchange rates of both PCBs and elemental mercury are dominated by the resistance in the aqueous thin film at the air/water interface and that water column elemental mercury concentrations in natural water bodies also display a diel cycle (and water column PCB concentrations do not) the findings here suggest that PCBs can serve as a tracer to assess the relative contribution of diel atmospheric temperature variations on elemental mercury air/water exchange rates.	Water	133-138	pyruvate carboxylase	Homo sapiens	38-41
11293414-1	2001	The water proton relaxation rate enhancement of the hepatospecific Gd-(S)-EOB-DTPA (Eovist) and of its (R) isomer in aqueous solutions free of protein, in serum and in 4% human serum albumin solution, are compared.	Water	4-9	albumin	Homo sapiens	177-190
11244570-3	2001	The main requirements for them are (1) high IFN-inducing activity, (2) absence of side effects, (3) wide spectrum of antimicrobial activity, (4) broad therapeutic security and, (5) good solubility in water and biologic liquids.	Water	200-205	interferon alpha 1	Homo sapiens	44-47
11252407-0	2001	GLP-1 inhibits gastric emptying of water but does not influence plasma.	Water	35-40	glucagon	Homo sapiens	0-5
11158269-1	2001	The water transport properties of the human Na+-coupled glutamate cotransporter (EAAT1) were investigated.	Water	4-9	solute carrier family 1 member 3	Homo sapiens	81-86
11158269-3	2001	Water transport by EAAT1 was bimodal.	Water	0-5	solute carrier family 1 member 3	Homo sapiens	19-24
11158269-13	2001	In the absence of glutamate, EAAT1 contributed a passive water permeability (Lp) of (11.3 +/- 2.0) x 10(-6) cm s(-1) (osmol l(-1))(-1).	Water	57-62	solute carrier family 1 member 3	Homo sapiens	29-34
11179430-8	2001	By testing the water-soluble MPD analog mannose-beta-1-P-citronellol in an in vitro system in which the MPD utilization defect was preserved by permeabilization with streptolysin-O, it was determined that Lec35p is not directly required for the enzymatic transfer of mannose from the donor to the acceptor substrate.	Water	15-20	mevalonate diphosphate decarboxylase	Homo sapiens	29-32
11273012-0	2001	Encapsulation of bovine serum albumin in poly(lactide-co-glycolide) microspheres by the solid-in-oil-in-water technique.	Water	104-109	albumin	Homo sapiens	24-37
11252407-9	2001	CONCLUSION: GLP-1 has a profound inhibitory effect on the gastric emptying of water in man, but no short-term effect on water homeostasis.	Water	78-83	glucagon	Homo sapiens	12-17
11456574-8	2001	Significantly, the tryptophan strand substitution is highly stabilizing with all turns tested, and peptides that display model turns or the less stable C"-C" " turn of CD4 on this tryptophan "stem" are highly structured beta-hairpins in water.	Water	237-242	CD4 molecule	Homo sapiens	168-171
11166419-3	2001	Prior to encapsulation, IGF-I was exposed to ultrasonication in a water/dichloromethane dispersion, and its stability tested in the presence and absence of various excipients in the W(1) phase.	Water	66-71	insulin like growth factor 1	Homo sapiens	24-29
11162605-7	2001	A mechanism involving a tyrosine-9-bound water molecule acting as a proton shuttle is proposed for the Michael additions catalyzed by GST A4-4.	Water	41-46	glutathione S-transferase alpha 4	Homo sapiens	134-142
11164508-6	2001	Previous injections of Sar into the SFO significantly reduced the water intake caused by ANG II injected into the LHA, whereas treatment with Sar in the ventral hippocampal commissure (VHC) or third ventricle (3V) was without effect.	Water	66-71	angiotensinogen	Rattus norvegicus	89-95
11121265-10	2001	In conclusion, it was demonstrated that HK activity depends on the microenvironment such as the electrostatic field, the physical properties of water, and the hydrophobicity.	Water	144-149	hexokinase 1	Homo sapiens	40-42
11227282-7	2001	At the regional scale, surface-water NO3 concentration in afforested catchments was negatively correlated with soil C/N ratios below 20.	Water	31-36	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
11181968-6	2001	EP1 and EP3 mRNA expression predominates in the collecting duct and thick limb, respectively, where their stimulation reduces NaCl and water absorption, promoting natriuresis and diuresis.	Water	135-140	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	0-3
11169715-0	2001	Structure and Base Catalysis of Supercritical Water in the Noncatalytic Benzaldehyde Disproportionation Using Water at High Temperatures and Pressures This work has been supported by CREST, JST (Japan Science and Technology Corporation), 4-1-8 Honcho, Kawaguchi 332-0012 (Japan).	Water	46-51	SS18L1 subunit of BAF chromatin remodeling complex	Homo sapiens	183-188
11199980-4	2001	The chain collapse mechanism for the C18 stationary phase at higher concentrations of water seems to be inhibited in the presence of 1-propanol, and partitioning is the predominant solute retention mechanism.	Water	86-91	Bardet-Biedl syndrome 9	Homo sapiens	37-40
11121887-7	2001	These results demonstrate that in astroglia-rich cultures catalase is strongly expressed in the predominant astroglial cells and in the minor population of oligodendroglial cells and that the enzyme is rapidly inactivated during the disposal of H(2)O(2), if the glutathione system of the cells is compromised.	Water	245-250	catalase	Rattus norvegicus	58-66
11035042-1	2001	Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes.	Water	16-21	aquaporin 3	Mus musculus	30-34
11035042-1	2001	Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes.	Water	91-96	aquaporin 3	Mus musculus	30-34
11270501-1	2001	Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel protein that plays an important role in electrolyte and water transport through the respiratory epithelial cells.	Water	137-142	CF transmembrane conductance regulator	Homo sapiens	0-51
11270501-1	2001	Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel protein that plays an important role in electrolyte and water transport through the respiratory epithelial cells.	Water	137-142	CF transmembrane conductance regulator	Homo sapiens	53-57
11124154-5	2001	min(-1) ANG II, attenuation of the induced increases in arterial pressure with the arteriolar vasodilator diazoxide resulted in greater water intakes and shorter latencies to drink.	Water	136-141	angiotensinogen	Rattus norvegicus	8-14
12203646-1	2001	The adhesion forces between individual molecules of Lewis(X) trisaccharide antigen (Le(X) ) have been measured in water and in calcium solution by using atomic force microscopy (AFM, see graph).	Water	114-119	fucosyltransferase 4	Homo sapiens	84-89
11181969-6	2001	Mutations have been identified in the aquaporin-2 gene (AQP2), which is located in chromosome region 12q13 and codes for the vasopressin-sensitive water channel.	Water	147-152	arginine vasopressin	Homo sapiens	125-136
12718659-2	2001	However, the species of glutathione S-transferases (GSTP1-1) linked to neoplasia of rat and human were recently shown to be selective for hydrophilic carcinogens such as acrolein and hydroxyalkenals (Satoh, 1998; Satoh et al., 1999) in accord with the finding of a water-network in the active site of the human GSTP1-1 by X-ray analysis (Hu et al.	Water	265-270	glutathione S-transferase pi 1	Rattus norvegicus	52-59
11233478-6	2001	Linear regression analysis showed an excellent correlation between the real volume of water in the balloons and volumes given in real time 3-dimensional echocardiography (y = 0.94x + 5.5, r = 0.99, p &lt; 0.001, D = -10 +/- 4.5 ml).	Water	86-91	CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion	Homo sapiens	212-219
11509828-9	2001	CONCLUSIONS: Our findings suggest that a non-AVP factor present in pregnancy plays a role in the control of the excretion of AQP-2 water channels.	Water	131-136	arginine vasopressin	Homo sapiens	45-48
11231887-4	2001	The isolated gene fragment was identical to Aquaporin 8 (AQP8), a water channel protein.	Water	66-71	aquaporin 8	Homo sapiens	44-55
11231887-4	2001	The isolated gene fragment was identical to Aquaporin 8 (AQP8), a water channel protein.	Water	66-71	aquaporin 8	Homo sapiens	57-61
11517855-1	2001	The aim of this study was to evaluate the antiinflammatory effect of Avene spring water on skin fragments stimulated by a neuromediator, vasoactive intestinal peptide (VIP).	Water	82-87	vasoactive intestinal peptide	Homo sapiens	168-171
11195058-6	2001	Whereas COX1 expression does not exhibit dynamic regulation, COX2 expression is subject to regulation by several environmental conditions, including salt intake, water intake, medullary tonicity, growth factors, cytokines, and adrenal steroids.	Water	162-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
11447767-0	2001	Inhibitory effect of sofalcone on tumor necrosis factor-alpha and interleukin-1 beta production in human monocytes stimulated by Helicobacter pylori water extract.	Water	149-154	tumor necrosis factor	Homo sapiens	34-61
11447767-0	2001	Inhibitory effect of sofalcone on tumor necrosis factor-alpha and interleukin-1 beta production in human monocytes stimulated by Helicobacter pylori water extract.	Water	149-154	interleukin 1 beta	Homo sapiens	66-84
11345542-10	2001	Both aeration and the C18 column treatments were effective in reducing toxicity from the pore water of the two stations included in the TIE.	Water	94-99	Bardet-Biedl syndrome 9	Homo sapiens	22-25
11517855-12	2001	Moreover, treatment with cellulose patches containing Avene spring water showed a decrease in TNF-alpha compared with skins treated with VIP.	Water	67-72	tumor necrosis factor	Homo sapiens	94-103
11215662-3	2001	This investigation studied the attenuation of nitrate (NO3- -N) as wastewater effluent flowed through the shallow ground water of a forested headwater riparian zone within the Appalachian Valley and Ridge physiographic province.	Water	72-77	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
11134245-6	2001	Restriction of water intake to increase vasopressin levels also significantly increased TAL ROMK immunolabeling and abundance in immunoblots.	Water	15-20	arginine vasopressin	Rattus norvegicus	40-51
16233144-7	2001	The water-insoluble sample greatly enhanced the growth of the human T cell line (H9) up to 1 x 10(5) with sample supplementation at 1.0 mg/l concentration from 4.3 x 10(4) without sample supplementation as well as improved the secretion level of both IL-6 and TNF-alpha up to 100 pg/ml from approximately 40 pg/ml without sample supplementation.	Water	4-9	interleukin 6	Homo sapiens	251-255
16233144-7	2001	The water-insoluble sample greatly enhanced the growth of the human T cell line (H9) up to 1 x 10(5) with sample supplementation at 1.0 mg/l concentration from 4.3 x 10(4) without sample supplementation as well as improved the secretion level of both IL-6 and TNF-alpha up to 100 pg/ml from approximately 40 pg/ml without sample supplementation.	Water	4-9	tumor necrosis factor	Homo sapiens	260-269
11215662-4	2001	Ground water flow and NO3- -N measurements indicated that NO3- -N discharged to the riparian zone preferentially flowed through the A and B horizons of depressional wetlands located in relic meander scars, with NO3- -N decreasing from &gt; 12 to &lt; 0.5 mg L(-1).	Water	7-12	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
11215662-4	2001	Ground water flow and NO3- -N measurements indicated that NO3- -N discharged to the riparian zone preferentially flowed through the A and B horizons of depressional wetlands located in relic meander scars, with NO3- -N decreasing from &gt; 12 to &lt; 0.5 mg L(-1).	Water	7-12	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
11136607-11	2001	The two deep-water species (false killer whale and striped dolphin) had significantly higher myoglobin concentrations than the three species (dusky, humpbacked and bottlenose dolphins) that occur in shallow, coastal waters.	Water	13-18	myoglobin	Tursiops truncatus	93-102
11155210-0	2001	Vasopressin regulates water flow in a rat cortical collecting duct cell line not containing known aquaporins.	Water	22-27	arginine vasopressin	Rattus norvegicus	0-11
11192702-3	2001	The crystal structure of bis(1,10-phenanthroline)(2-methyl-4-chloro-phenoxyacetato)copper(ll) chloride-methanol(1/1)-water(1/0.6), 1 has been determined and refined by least-squares methods using three-dimensional MoK, data.	Water	117-122	MOK protein kinase	Homo sapiens	214-217
11686391-2	2001	The control group received solid diet (Purina rat chow) and tap water ad libitum.	Water	64-69	nuclear RNA export factor 1	Rattus norvegicus	60-63
15348370-3	2001	We examined the action of a water-soluble extract of nacre on the osteoblast phenotype of cells isolated from rat neonatal calvaria by measuring alkaline phosphatase (ALP) activity and by localization of the anti-apoptotic protein Bcl-2 by immunocytochemistry.	Water	28-33	BCL2, apoptosis regulator	Rattus norvegicus	231-236
11321891-10	2001	Water extracts from cagA positive strains enhanced the release of PGC in mucosal biopsy supernatants (p &lt; 0.05) when patients were considered overall and the release of TNF alpha (p &lt; 0.05) when only patients with duodenal ulcer were considered.	Water	0-5	progastricsin	Homo sapiens	66-69
11321891-10	2001	Water extracts from cagA positive strains enhanced the release of PGC in mucosal biopsy supernatants (p &lt; 0.05) when patients were considered overall and the release of TNF alpha (p &lt; 0.05) when only patients with duodenal ulcer were considered.	Water	0-5	tumor necrosis factor	Homo sapiens	172-181
11321891-13	2001	In conclusion, pepsinogen C and TNF alpha can be induced by cagA positive water extracts and may contribute to damage the gastric and duodenal mucosa.	Water	74-79	tumor necrosis factor	Homo sapiens	32-41
11174016-6	2001	Intracerebroventricular AII (500 ng) increased water intake, and induced a significant increase in CNP expression at 4 h in olfactory regions, but not in other brain sites.	Water	47-52	angiotensinogen	Rattus norvegicus	24-27
11190985-2	2001	Growth hormone has been shown to increase amino acid, water, and electrolyte absorption from the small intestine.	Water	54-59	growth hormone 1	Homo sapiens	0-14
11601531-8	2001	The sum of PCB concentrations in water were higher in the Bering Sea area compared to the Chukchi Sea (1.0 vrs 0.67 ng/L) and lower for air (0.46 vrs 0.23 ng/m3).	Water	33-38	pyruvate carboxylase	Homo sapiens	11-14
11174021-4	2001	A high VP level is beneficial in the short term because it limits to some extent the amount of water required for the excretion of a markedly enhanced load of osmoles (mainly glucose).	Water	95-100	arginine vasopressin	Rattus norvegicus	7-9
11301205-5	2001	Voltage-gated Ca2+ channel blockade with the L-type antagonist nitrendipine (10 microM) decreased Ca entry and modestly preserved CA1 cell elemental composition and water content.	Water	165-170	carbonic anhydrase 2	Rattus norvegicus	14-17
11311543-0	2001	Transgenic mice with neuronal overexpression of bcl-2 gene present navigation disabilities in a water task.	Water	96-101	B cell leukemia/lymphoma 2	Mus musculus	48-53
11093266-9	2001	In the case of one of the substrates, CpA, we have also identified the presence of a water molecule that invariantly bridges the B2 base with the protein.	Water	85-90	carboxypeptidase A1	Homo sapiens	38-41
11280499-2	2001	In patients with normal renal function, vasopressin is needed to prevent the excretion of electrolyte-free water.	Water	107-112	arginine vasopressin	Homo sapiens	40-51
11734357-2	2001	In experiment 1, apoE-knockout and wild-type mice were repeatedly subjected to an environmental challenge (i.e. exposure to rats) and the effect was monitored on Morris water maze performance.	Water	169-174	apolipoprotein E	Mus musculus	17-21
11734357-3	2001	Naive apoE-knockout mice were impaired, but surprisingly after rat stress their water maze performance improved and switched to a goal-directed search strategy.	Water	80-85	apolipoprotein E	Mus musculus	6-10
11219814-3	2001	The water sorption behaviour of the pectin-DHP complex was determined at several relative vapour pressures and compared with those obtained on pectin, DHP and a blend of both polymers in the same proportion as in the complex.	Water	4-9	dihydropyrimidinase	Homo sapiens	43-46
11724482-1	2001	The objective of the project is to establish a conceptual groundwater model over the lower Nam Kam Basin in order to apply a numerical technique for the prediction of the impact of saline water transport due to the proposed weir across the Nam Kam River.	Water	64-69	SH3 and cysteine rich domain 3	Homo sapiens	91-94
11957779-9	2001	The concentration of NO3- in water was determined (in situ) with the Merckoquant Nitrate test kits of the Merck Company.	Water	29-34	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
11957779-10	2001	The obtained results show that the NO3- concentration in the water of the majority of studied wells exceeds clearly the acceptable NO3- drinking water standard established for drinking water by WHO.	Water	61-66	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
11957779-10	2001	The obtained results show that the NO3- concentration in the water of the majority of studied wells exceeds clearly the acceptable NO3- drinking water standard established for drinking water by WHO.	Water	145-150	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
11957779-10	2001	The obtained results show that the NO3- concentration in the water of the majority of studied wells exceeds clearly the acceptable NO3- drinking water standard established for drinking water by WHO.	Water	145-150	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
11957779-10	2001	The obtained results show that the NO3- concentration in the water of the majority of studied wells exceeds clearly the acceptable NO3- drinking water standard established for drinking water by WHO.	Water	145-150	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
11957779-10	2001	The obtained results show that the NO3- concentration in the water of the majority of studied wells exceeds clearly the acceptable NO3- drinking water standard established for drinking water by WHO.	Water	145-150	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
11394278-3	2001	The best pilot plant operational condition was obtained applying only 4.0 g/m3 (S*) with Vh around 18 cm.min-1 for treatment of water coagulated with a Al2(SO4)3 dosage of 40 mg.l-1.	Water	128-133	CD59 molecule (CD59 blood group)	Homo sapiens	105-110
11770034-12	2001	We conclude that removal of bradykinin and a decrease in the levels of NH3, potassium, and pH play a significant role in reducing water retention and postoperative lung injury.	Water	130-135	kininogen 1	Homo sapiens	28-38
11724482-1	2001	The objective of the project is to establish a conceptual groundwater model over the lower Nam Kam Basin in order to apply a numerical technique for the prediction of the impact of saline water transport due to the proposed weir across the Nam Kam River.	Water	64-69	SH3 and cysteine rich domain 3	Homo sapiens	240-243
11140684-2	2000	In the water maze, hAPP mice are impaired before and after amyloid plaque deposition.	Water	7-12	amyloid beta precursor protein	Homo sapiens	19-23
12516391-7	2000	The water contents were positive linar correlated with IL-1 beta or TNF-alpha(P &gt; 0.05).	Water	4-9	interleukin 1 beta	Homo sapiens	55-64
12516391-7	2000	The water contents were positive linar correlated with IL-1 beta or TNF-alpha(P &gt; 0.05).	Water	4-9	tumor necrosis factor	Homo sapiens	68-77
12516391-8	2000	The water contents were positive linear correlated with IL-1 beta or TNF-alpha contents(r = 0.9381, 0.8349, P &lt; 0.01).	Water	4-9	interleukin 1 beta	Homo sapiens	56-65
12516391-8	2000	The water contents were positive linear correlated with IL-1 beta or TNF-alpha contents(r = 0.9381, 0.8349, P &lt; 0.01).	Water	4-9	tumor necrosis factor	Homo sapiens	69-78
11144281-0	2000	Effect of water-soluble matrix fraction extracted from the nacre of Pinctada maxima on the alkaline phosphatase activity of cultured fibroblasts.	Water	10-15	alkaline phosphatase, placental	Homo sapiens	91-111
11113627-8	2000	In RHEC, high glucose (22 mM) and H(2)O(2) (100 microM) were able to increase the mRNA encoding ecNOS, but not iNOS.	Water	34-39	nitric oxide synthase 2	Rattus norvegicus	111-115
11118622-7	2000	This cDNA encodes a 274-amino acid protein showing a high sequence identity with mammalian aquaporin-8 (AQP8) water channel (35%) and d-TIP (34%), an AQP of Arabidopsis.	Water	110-115	aquaporin 8	Homo sapiens	91-102
11118622-7	2000	This cDNA encodes a 274-amino acid protein showing a high sequence identity with mammalian aquaporin-8 (AQP8) water channel (35%) and d-TIP (34%), an AQP of Arabidopsis.	Water	110-115	aquaporin 8	Homo sapiens	104-108
11233675-1	2000	This study reports a comparison of Fluorine-18 deoxyglucose positron emission tomography (FDG-PET) and O-15 water (H2(15)O) PET with regard to lateralization of the seizure focus in patients with complex partial epilepsy.	Water	108-113	immunoglobulin kappa variable 2-36 (pseudogene)	Homo sapiens	103-107
11152270-1	2000	Polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS) was used to follow the hydrolysis of phospholipid monolayers at the air-water interface by phospholipase A2 (PLA2).	Water	150-155	phospholipase A2 group IB	Homo sapiens	169-185
11152270-1	2000	Polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS) was used to follow the hydrolysis of phospholipid monolayers at the air-water interface by phospholipase A2 (PLA2).	Water	150-155	phospholipase A2 group IB	Homo sapiens	187-191
11152270-5	2000	This observation supports our previously postulated mechanism for the formation of PLA2 domains at the air-water interface.	Water	107-112	phospholipase A2 group IB	Homo sapiens	83-87
11145096-1	2000	In the kidney, binding of arginine vasopressin to the vasopressin type-2 receptor (V2R) causes redistribution of aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical cell membrane, a process which initiates urine concentration.	Water	132-137	arginine vasopressin	Homo sapiens	35-46
11145096-1	2000	In the kidney, binding of arginine vasopressin to the vasopressin type-2 receptor (V2R) causes redistribution of aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical cell membrane, a process which initiates urine concentration.	Water	132-137	arginine vasopressin receptor 2	Homo sapiens	54-86
11121486-1	2000	The dynamic behavior of HIV-1 TAR and its complex with argininamide is investigated by means of molecular dynamics simulations starting from NMR structures, with explicit inclusion of water and periodic boundary conditions particle mesh Ewald representation of the electrostatic energy.	Water	184-189	RNA binding motif protein 8A	Homo sapiens	30-33
11042546-0	2000	Phase equilibria in the lysozyme-ammonium sulfate-water system.	Water	50-55	lysozyme	Homo sapiens	24-32
11118975-1	2000	The Co(II) ion lies on an inversion centre and is octahedrally coordinated to two trimesate anions and four water molecules.	Water	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
11108250-3	2000	In the present study, a 7-day intracerebroventricular infusion to male rats of either the MC receptor antagonist SHU9119 or porcine NPY (10 nmol/day) was shown to strongly stimulate food and water intake and to markedly increase fat pad mass.	Water	191-196	neuropeptide Y	Rattus norvegicus	132-135
11097619-6	2000	In contrast, administration of NH(4)Cl in the drinking water for 2 wk (free access to water) revealed a significant increase in AQP6 protein abundance (194 +/- 9% of control), but this was associated with increased water intake.	Water	86-91	aquaporin 6	Rattus norvegicus	128-132
11097619-7	2000	Combined, this suggests that AQP6 expression was not affected by acid loading per se but rather was in response to changes in water intake.	Water	126-131	aquaporin 6	Rattus norvegicus	29-33
11097619-8	2000	Consistent with this, water loading for 48 h was associated with increased AQP6 protein abundance, compared with thirsted rats.	Water	22-27	aquaporin 6	Rattus norvegicus	75-79
11201437-10	2000	When carcases were held overnight in the rig at 11 degrees C after chilling, microbe counts on dry-chilled carcases remained stable, but increased on carcases that had been sprayed with chlorinated water.	Water	198-203	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	41-44
11097629-12	2000	This suggests that vasopressin-mediated renal water reabsorption capacity was increased in the cirrhotic rats.	Water	46-51	arginine vasopressin	Rattus norvegicus	19-30
11097629-13	2000	Semiquantitative immunoblotting revealed that the expression of the vasopressin-regulated water channel aquaporin-2 was unchanged in membrane fractions of both whole kidney and inner medulla from cirrhotic rats.	Water	90-95	arginine vasopressin	Rattus norvegicus	68-79
11097629-14	2000	Together, these results suggest a relative escape from vasopressin on collecting duct water reabsorption in rats with decompensated liver cirrhosis.	Water	86-91	arginine vasopressin	Rattus norvegicus	55-66
11085929-10	2000	Microinjection of mENT1, mENT1b or mENT2 cRNA into Xenopus oocytes resulted in enhanced uptake of [(3)H]uridine by the oocytes relative to that seen in water-injected controls.	Water	152-157	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	35-40
11091117-3	2000	Mutations that abrogate the production and/or release of AVP from the pituitary have diabetes insipidus as their most dramatic manifestation, indicating that the maintenance of water homeostasis is the most important physiological role of this neuropeptide.	Water	177-182	arginine vasopressin	Homo sapiens	57-60
11228040-0	2000	A case of isolated ACTH deficiency who developed autoimmune-mediated hypothyroidism and impaired water diuresis during glucocorticoid replacement therapy.	Water	97-102	proopiomelanocortin	Homo sapiens	19-23
11228040-1	2000	A case of isolated ACTH deficiency who developed autoimmune-mediated hypothyroidism and still showed impaired water diuresis during glucocorticoid replacement therapy is reported.	Water	110-115	proopiomelanocortin	Homo sapiens	19-23
11120759-6	2000	Catalase, which dismutates H(2)O(2) to form water and oxygen, inhibited EDHF-mediated relaxation and hyperpolarization, but it did not affect endothelium-independent relaxation following treatment with the K(+) channel opener levcromakalim.	Water	44-49	catalase	Mus musculus	0-8
11137977-5	2000	RESULTS: Body temperature, heart rate, systolic blood pressure and plasma growth hormone (GH) were significantly elevated in both groups after swimming in water of either temperature (P &lt; 0.01).	Water	155-160	growth hormone 1	Homo sapiens	74-88
11137977-5	2000	RESULTS: Body temperature, heart rate, systolic blood pressure and plasma growth hormone (GH) were significantly elevated in both groups after swimming in water of either temperature (P &lt; 0.01).	Water	155-160	growth hormone 1	Homo sapiens	90-92
11091002-9	2000	It was established that activities of NAD(P)H reductase and content of cytochrome P450 were normalised in liver microsomes of hyperlipidemic rats, if the animals were treated with STF1 (2 g/bwkg for 9 days in drinking water parallel with fat-rich diet feeding).	Water	218-223	pancreatic and duodenal homeobox 1	Rattus norvegicus	180-184
12903404-2	2000	METHODS: The experiment was carried out under the low water activity condition, using tosylate chloride activating side-chain hydroxyl group of Sepharose CL-4B agarose to form a high active group which could react with the free amino-group of ACE to link the enzyme with agarose.	Water	54-59	angiotensin I converting enzyme	Homo sapiens	243-246
10992240-0	2000	Peroxidase-catalyzed asymmetric sulfoxidation in organic solvents versus in water.	Water	76-81	peroxidase	Glycine max	0-10
11101232-4	2000	It was found that by employing an amperometric pulse detection mode and pure water as eluent, the detection limit of the ionode detector could be lowered to ppt level of salt concentrations under flowing conditions.	Water	77-82	tachykinin precursor 1	Homo sapiens	157-160
11076974-1	2000	In renal principal cells, vasopressin regulates the shuttling of the aquaporin (AQP)2 water channel between intracellular vesicles and the apical plasma membrane.	Water	86-91	arginine vasopressin	Homo sapiens	26-37
10992240-6	2000	Sulfoxidation of thioanisole catalyzed by four other hemoproteins (soybean peroxidase, myoglobin, hemoglobin, and cytochrome c) is also much faster in isopropyl alcohol than in water.	Water	177-182	peroxidase	Glycine max	75-85
10992240-1	2000	Peroxidase-catalyzed asymmetric sulfoxidations, while synthetically attractive, suffer from relatively low reaction rates due to poor substrate solubilities in water and from appreciable spontaneous oxidation of substrates (especially aryl alkyl sulfides) with H(2)O(2).	Water	160-165	peroxidase	Glycine max	0-10
10992240-1	2000	Peroxidase-catalyzed asymmetric sulfoxidations, while synthetically attractive, suffer from relatively low reaction rates due to poor substrate solubilities in water and from appreciable spontaneous oxidation of substrates (especially aryl alkyl sulfides) with H(2)O(2).	Water	261-266	peroxidase	Glycine max	0-10
10992240-4	2000	In addition, the rates of asymmetric sulfoxidation of thioanisole in isopropyl alcohol and in methanol catalyzed by horseradish peroxidase (HRP) were determined to be tens to hundreds of times faster than in water under otherwise identical conditions.	Water	208-213	peroxidase	Glycine max	128-138
11080323-12	2000	Water accumulations at a 45 degrees angle were: AeroVent 0.765 +/- 0.152 g; OptiVent 1.894 +/- 0.228 g; and ACE 4.043 +/- 0.665 g through 6 hours of use.	Water	0-5	angiotensin I converting enzyme	Homo sapiens	108-111
11061988-6	2000	These results support a CYP3A-dependent mechanism of side chain metabolism of tocopherols to water-soluble carboxychromans, and provide the first evidence of a specific enzyme involved in vitamin E metabolism.	Water	93-98	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	24-29
11053145-0	2000	Molecular dynamics of solid-state lysozyme as affected by glycerol and water: a neutron scattering study.	Water	71-76	lysozyme	Homo sapiens	34-42
11053145-8	2000	Upon the addition of glycerol or water, anharmonicity was recovered above a dynamic transition temperature (T(d)), which may contribute to the reduction of T(m) values for dehydrated lysozyme in the presence of glycerol.	Water	33-38	lysozyme	Homo sapiens	183-191
11053145-9	2000	The greatest degree of anharmonicity, as well as the lowest T(d), was observed for lysozyme solvated with water.	Water	106-111	lysozyme	Homo sapiens	83-91
10973964-2	2000	In the renal collecting duct, vasopressin increases osmotic water permeability (P(f)) by triggering trafficking of aquaporin-2 vesicles to the apical plasma membrane.	Water	60-65	arginine vasopressin	Homo sapiens	30-41
11063906-0	2000	Mitochondrial or cytosolic catalase reverses the MnSOD-dependent inhibition of proliferation by enhancing respiratory chain activity, net ATP production, and decreasing the steady state levels of H(2)O(2).	Water	196-201	catalase	Homo sapiens	27-35
11065345-7	2000	The overall effect of NHE3 inactivation on BP may also involve absorptive defects in the intestine and colon, where the exchanger normally reabsorbs significant amounts of Na(+) and water.	Water	182-187	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	22-26
11053490-1	2000	Previous studies have established that the vasopressin-regulated water channel of the collecting duct, aquaporin-2, is excreted in the urine, providing a means for assessment of regulation and dysregulation of aquaporin-2 in humans.	Water	65-70	arginine vasopressin	Homo sapiens	43-54
11073261-2	2000	The charge state distributions of cytochrome c and myoglobin, formed from 47%/50%/3% water/solvent/acetic acid solutions, shift to lower charge (higher m/z) when the 50% solvent fraction is changed from water to methanol, to acetonitrile, to isopropanol.	Water	85-90	cytochrome c, somatic	Homo sapiens	34-46
11073261-7	2000	Addition of even small amounts of two solvents that are less volatile than water, ethylene glycol and 2-methoxyethanol, also results in preferential deprotonation of higher charge state ions of small peptides, but these solvents actually produce an enhancement in the higher charge state ions for both cytochrome c and myoglobin.	Water	75-80	cytochrome c, somatic	Homo sapiens	302-314
11073261-2	2000	The charge state distributions of cytochrome c and myoglobin, formed from 47%/50%/3% water/solvent/acetic acid solutions, shift to lower charge (higher m/z) when the 50% solvent fraction is changed from water to methanol, to acetonitrile, to isopropanol.	Water	203-208	cytochrome c, somatic	Homo sapiens	34-46
11071255-2	2000	Water contaminated with inflammatory substances induced the pro-inflammatory hormone interleukin 6 (IL-6).	Water	0-5	interleukin 6	Homo sapiens	85-98
11104257-0	2000	Viscoelastic properties of oil-water interfaces covered by bovine beta-casein tryptic peptides.	Water	31-36	casein beta	Bos taurus	66-77
11104257-2	2000	Identification of the peptides produced by trypsin hydrolysis of beta-CN in emulsion at 37 degrees C provided information on the structure of beta-CN adsorbed at the oil-water interface.	Water	170-175	casein beta	Bos taurus	65-72
11104257-2	2000	Identification of the peptides produced by trypsin hydrolysis of beta-CN in emulsion at 37 degrees C provided information on the structure of beta-CN adsorbed at the oil-water interface.	Water	170-175	casein beta	Bos taurus	142-149
11104257-6	2000	Film made with the purified peptide beta-CN (f114-169) was merely elastic at the triolein-water interface.	Water	90-95	casein beta	Bos taurus	36-43
11124587-1	2000	Previous studies in female rats have shown that estrogen treatment attenuates angiotensin II (AngII)-induced water intake.	Water	109-114	angiotensinogen	Rattus norvegicus	78-92
11124587-1	2000	Previous studies in female rats have shown that estrogen treatment attenuates angiotensin II (AngII)-induced water intake.	Water	109-114	angiotensinogen	Rattus norvegicus	94-99
11124587-4	2000	Therefore, an estrogen-modulated change in neuronal pathways relevant to AngII-induced water intake was tested in ovariectomized (OVX) female rats using immunohistochemistry for the immediate early gene c-Fos as a marker for neuronal activation.	Water	87-92	angiotensinogen	Rattus norvegicus	73-78
11124587-8	2000	Such changes in neuronal activation may explain the estrogen modulation of AngII-induced water intake that has been previously reported; it may be due to increased water retention to maintain plasma osmolality or to induction of a pressor response.	Water	89-94	angiotensinogen	Rattus norvegicus	75-80
11124587-8	2000	Such changes in neuronal activation may explain the estrogen modulation of AngII-induced water intake that has been previously reported; it may be due to increased water retention to maintain plasma osmolality or to induction of a pressor response.	Water	164-169	angiotensinogen	Rattus norvegicus	75-80
11205061-12	2000	Our evidence for the basolateral localization of rAQP8 in acinar cells, coupled with previous findings that AQP5 is localized apically in the same cells, raises the possibility that water crosses the acinar epithelium through these channels during primary saliva formation.	Water	182-187	aquaporin 8	Rattus norvegicus	49-54
11063421-1	2000	Insulin-loaded microparticles were produced from blends of poly(ethylene glycol) (PEG) with poly (L-lactide) (PLA) homopolymer and poly (DL-lactide co-glycolide) copolymers (PLG) using a water-in-oil solvent extraction method.	Water	187-192	insulin	Homo sapiens	0-7
11050138-3	2000	Four hours after injection of IL-1beta (1 ng in 1 microliter), cerebral blood volume was significantly increased, the blood-brain barrier (BBB) became permeable to intravenously administered contrast agent between 4.5 and 5 hr, and the apparent diffusion coefficient (ADC) of brain water fell by 6 hr (5.42 +/- 0.	Water	282-287	interleukin 1 beta	Rattus norvegicus	30-38
11050138-9	2000	The presence of neutrophils within the brain parenchyma significantly contributed to the IL-1beta-induced changes in cerebral blood volume and the ADC of brain water.	Water	160-165	interleukin 1 beta	Rattus norvegicus	89-97
11071255-2	2000	Water contaminated with inflammatory substances induced the pro-inflammatory hormone interleukin 6 (IL-6).	Water	0-5	interleukin 6	Homo sapiens	100-104
11071255-3	2000	All water samples collected from the Eerste River, Stellenbosch, induced IL-6 secretion, and the quantity of IL-6 secreted is dependent on the concentration and origin of the sample.	Water	4-9	interleukin 6	Homo sapiens	73-77
11015223-3	2000	Ferric PGHS-1 has a predominant six-coordinate high-spin heme at room temperature, with water as the sixth ligand.	Water	88-93	prostaglandin-endoperoxide synthase 1	Homo sapiens	7-13
11198421-1	2000	The chlorophyll a-binding protein CP47 directs excitation energy to the reaction center of photosystem II (PSII) during oxygenic photosynthesis and has additional structural and functional roles associated with the PSII water-oxidizing complex.	Water	220-225	beaded filament structural protein 2	Homo sapiens	34-38
11027237-5	2000	Under water-depleted conditions, c-fos expression was markedly elevated in neurons in the subfornical organ and organum vasculosum laminae terminalis compared with wild-type animals, suggesting a hyperactive state in the Na(v)2-null mice.	Water	6-11	neuron navigator 2	Mus musculus	221-227
11036156-0	2000	Effects of subtypes alpha- and beta-adrenoceptors of the lateral hypothalamus on the water and sodium intake induced by angiotensin II injected into the subfornical organ.	Water	85-90	angiotensinogen	Rattus norvegicus	120-134
11036156-3	2000	These data show that injection of 5-methylurapidil into the LH prior to ANG II into the SFO increased the water and sodium intake induced by the injection of ANG II.	Water	106-111	angiotensinogen	Rattus norvegicus	158-164
11036156-5	2000	Thus, the alpha(1)- and beta-adrenoceptors of the LH are possibly involved with central mechanisms dependent on ANG II and SFO that control water and sodium intake.	Water	140-145	angiotensinogen	Rattus norvegicus	112-118
11041868-9	2000	Release of P(i), after hydrolysis, caused a decrease in the accessibility of MRP1 to the water phase which brings the protein back to its initial conformation.	Water	89-94	ATP binding cassette subfamily C member 1	Homo sapiens	77-81
11032997-9	2000	Besides the previously demonstrated importance for the control of ANG II-dependent water and NaCl intake, the data show that the serotonergic inhibitory mechanisms of the LPBN are also involved in the control of DOCA-induced NaCl intake.	Water	83-88	angiotensinogen	Rattus norvegicus	66-72
11034202-0	2000	Structural determinants of water permeation through aquaporin-1.	Water	27-32	aquaporin 1 (Colton blood group)	Homo sapiens	52-63
11052097-6	2000	The new analogue, containing an additional hydroxyl group at C21, exhibits advantages over other epothilones in terms of water solubility, and can serve as a readily functionalizable handle to produce other useful compounds for pertinent biological studies.	Water	121-126	TBL1X/Y related 1	Homo sapiens	61-64
11034202-1	2000	Human red cell AQP1 is the first functionally defined member of the aquaporin family of membrane water channels.	Water	97-102	aquaporin 1 (Colton blood group)	Homo sapiens	15-19
11037022-4	2000	CONCLUSIONS: As a consequence of age-associated diminished renal concentrating capacity, diminished sodium conserving ability, loss of the circadian rhythm of antidiuretic hormone secretion, decreased secretion of renin-angiotensin-aldosterone, and increased secretion of atrial natriuretic hormone, there is an age-related alteration in the circadian rhythm of water excretion leading to increased nighttime urine production in older people.	Water	362-367	renin	Homo sapiens	214-219
10998045-11	2000	The simplest mechanism for the overall reaction which fit the experimental data is the following: MPO+H2O2 &amp;rlarr;k-1k1 MPO-I+H2O MPO-I+Cl- &amp;rlarr;k-2k2 MPO-I-Cl- MPO-I-Cl- --&gt;k3 MPO+HOCl where MPO-I-Cl- is a chlorinating intermediate.	Water	102-105	myeloperoxidase	Homo sapiens	98-101
10998045-11	2000	The simplest mechanism for the overall reaction which fit the experimental data is the following: MPO+H2O2 &amp;rlarr;k-1k1 MPO-I+H2O MPO-I+Cl- &amp;rlarr;k-2k2 MPO-I-Cl- MPO-I-Cl- --&gt;k3 MPO+HOCl where MPO-I-Cl- is a chlorinating intermediate.	Water	102-105	myeloperoxidase	Homo sapiens	124-127
10998045-11	2000	The simplest mechanism for the overall reaction which fit the experimental data is the following: MPO+H2O2 &amp;rlarr;k-1k1 MPO-I+H2O MPO-I+Cl- &amp;rlarr;k-2k2 MPO-I-Cl- MPO-I-Cl- --&gt;k3 MPO+HOCl where MPO-I-Cl- is a chlorinating intermediate.	Water	102-105	myeloperoxidase	Homo sapiens	124-127
10998045-11	2000	The simplest mechanism for the overall reaction which fit the experimental data is the following: MPO+H2O2 &amp;rlarr;k-1k1 MPO-I+H2O MPO-I+Cl- &amp;rlarr;k-2k2 MPO-I-Cl- MPO-I-Cl- --&gt;k3 MPO+HOCl where MPO-I-Cl- is a chlorinating intermediate.	Water	102-105	myeloperoxidase	Homo sapiens	124-127
10998045-11	2000	The simplest mechanism for the overall reaction which fit the experimental data is the following: MPO+H2O2 &amp;rlarr;k-1k1 MPO-I+H2O MPO-I+Cl- &amp;rlarr;k-2k2 MPO-I-Cl- MPO-I-Cl- --&gt;k3 MPO+HOCl where MPO-I-Cl- is a chlorinating intermediate.	Water	102-105	myeloperoxidase	Homo sapiens	124-127
10998045-11	2000	The simplest mechanism for the overall reaction which fit the experimental data is the following: MPO+H2O2 &amp;rlarr;k-1k1 MPO-I+H2O MPO-I+Cl- &amp;rlarr;k-2k2 MPO-I-Cl- MPO-I-Cl- --&gt;k3 MPO+HOCl where MPO-I-Cl- is a chlorinating intermediate.	Water	102-105	myeloperoxidase	Homo sapiens	124-127
10998045-11	2000	The simplest mechanism for the overall reaction which fit the experimental data is the following: MPO+H2O2 &amp;rlarr;k-1k1 MPO-I+H2O MPO-I+Cl- &amp;rlarr;k-2k2 MPO-I-Cl- MPO-I-Cl- --&gt;k3 MPO+HOCl where MPO-I-Cl- is a chlorinating intermediate.	Water	102-105	myeloperoxidase	Homo sapiens	124-127
11033421-5	2000	(1) The inhibition by H(2)O(2) of VP-16-induced apoptosis and cellular caspase-3 activity can be overcome by adding inhibitors of poly(ADP-ribose) polymerase (PARP) at sub-stoichiometric concentrations.	Water	22-27	caspase 3	Homo sapiens	71-80
11033421-5	2000	(1) The inhibition by H(2)O(2) of VP-16-induced apoptosis and cellular caspase-3 activity can be overcome by adding inhibitors of poly(ADP-ribose) polymerase (PARP) at sub-stoichiometric concentrations.	Water	22-27	poly(ADP-ribose) polymerase 1	Homo sapiens	130-157
11033421-5	2000	(1) The inhibition by H(2)O(2) of VP-16-induced apoptosis and cellular caspase-3 activity can be overcome by adding inhibitors of poly(ADP-ribose) polymerase (PARP) at sub-stoichiometric concentrations.	Water	22-27	poly(ADP-ribose) polymerase 1	Homo sapiens	159-163
11033421-8	2000	(4) Addition of H(2)O(2) to cells inhibits activation of caspase-9, which is required for activation of caspase-3.	Water	16-21	caspase 3	Homo sapiens	104-113
11017197-0	2000	von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule.	Water	89-94	von Willebrand factor	Homo sapiens	0-21
11043582-1	2000	In the kidney, water reabsorption is mainly regulated by the binding of arginine vasopressin to vasopressin type 2 (V2) receptors.	Water	15-20	arginine vasopressin	Homo sapiens	81-92
11043582-1	2000	In the kidney, water reabsorption is mainly regulated by the binding of arginine vasopressin to vasopressin type 2 (V2) receptors.	Water	15-20	arginine vasopressin	Homo sapiens	96-107
10956231-0	2000	Water ingestion provides an early signal inhibiting osmotically stimulated vasopressin secretion in rats.	Water	0-5	arginine vasopressin	Rattus norvegicus	75-86
10942736-12	2000	Deferoxamine, a metal chelator, inhibited p53 activation by chelating Cr(V) to make it incapable of generating radicals from H(2)O(2).	Water	125-130	tumor protein p53	Homo sapiens	42-45
10957645-0	2000	Crystallization and preliminary X-ray crystallographic analysis of water channel AQP1.	Water	67-72	aquaporin 1	Bos taurus	81-85
10957645-1	2000	Aquaporin-1 (AQP1), a water channel from bovine red blood cells has been deglycosylated, purified to homogeneity and crystallized in a form suitable for X-ray crystallographic study.	Water	22-27	aquaporin 1	Bos taurus	0-11
10957645-1	2000	Aquaporin-1 (AQP1), a water channel from bovine red blood cells has been deglycosylated, purified to homogeneity and crystallized in a form suitable for X-ray crystallographic study.	Water	22-27	aquaporin 1	Bos taurus	13-17
10956231-1	2000	Dehydrated dogs are known to inhibit secretion of vasopressin (VP) within minutes after drinking water, before plasma osmolality (P(osmol)) diminishes.	Water	97-102	arginine vasopressin	Rattus norvegicus	50-61
10994965-8	2000	The signal-to-noise ratio from the infusion of a 10 nM cytochrome c solution in 100% water at 100 nL/min was 450:1.	Water	85-90	cytochrome c, somatic	Homo sapiens	55-67
11028030-0	2000	Dynamic Observations of the Hydrolysis of a DPPC Monolayer at the Air/Water Interface Catalyzed by Phospholipase A(2) This work was supported by the research contract between the German Max-Planck-Society and the Chinese Academy of Sciences as well as the National Natural Science Foundation of China (NNSF).	Water	70-75	phospholipase A2 group IB	Homo sapiens	99-116
10950813-5	2000	During water deprivation, JNK-2 increased in the supraoptic nucleus but not in the cortex.	Water	7-12	mitogen-activated protein kinase 9	Homo sapiens	26-31
10969004-1	2000	The effect of monolayer domain formation on the electrostatic coupling of cytochrome c from the subphase to a monolayer at the air/water interface was studied using a combination of neutron reflection (NR) and infrared reflection absorption spectroscopy (IRRAS) techniques.	Water	131-136	cytochrome c, somatic	Homo sapiens	74-86
11858448-4	2000	Water-soluble fiber appears to have a greater potential to reduce postprandial blood glucose, insulin, and serum lipid levels than insoluble fiber.	Water	0-5	insulin	Homo sapiens	94-101
10976868-1	2000	The time-resolved fluorescence intensity and anisotropy decays of the immunophilin domain of FKBP59 (FKBP59-I)--a protein containing two tryptophan residues (the W89, buried in a hydrophobic pocket and the W59, water exposed)--were studied using the time-correlated single photon counting (TCSPC) technique.	Water	211-216	FKBP prolyl isomerase 4	Homo sapiens	93-99
10976868-1	2000	The time-resolved fluorescence intensity and anisotropy decays of the immunophilin domain of FKBP59 (FKBP59-I)--a protein containing two tryptophan residues (the W89, buried in a hydrophobic pocket and the W59, water exposed)--were studied using the time-correlated single photon counting (TCSPC) technique.	Water	211-216	FKBP prolyl isomerase 4	Homo sapiens	101-109
10974048-4	2000	The elastic modulus of chicken apoA-IV at the air/water interface was 13.7 mN/m, versus 21.7 mN/m for human apoA-IV and 7.6 mN/m for apoA-I.	Water	50-55	apolipoprotein A1	Homo sapiens	31-37
12189288-10	2000	These data would strongly suggest that the selective cyclo-oxygenase-2 inhibitors could decrease glomerular filtration rate and stimulate salt and water retention, comparable to what occurs with nonselective NSAIDs.	Water	147-152	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-70
10973923-2	2000	We previously reported on the ability of TGF-beta1 to activate a cell surface-associated NADH:flavin:O(2) oxidoreductase (NADH oxidase) that generates extracellular H(2)O(2).	Water	165-170	transforming growth factor beta 1	Homo sapiens	41-50
10942539-0	2000	Incompatibility and Phase Separation in a Bovine Serum Albumin/beta-Casein/Water Ternary Film at the Air-Water Interface.	Water	105-110	albumin	Homo sapiens	49-62
10990371-4	2000	Mice lacking AQP3, a basolateral membrane water channel expressed mainly in the cortical collecting duct, are remarkably polyuric but are able to generate a partly concentrated urine after water deprivation.	Water	42-47	aquaporin 3	Mus musculus	13-17
10990371-4	2000	Mice lacking AQP3, a basolateral membrane water channel expressed mainly in the cortical collecting duct, are remarkably polyuric but are able to generate a partly concentrated urine after water deprivation.	Water	189-194	aquaporin 3	Mus musculus	13-17
10969149-4	2000	Ethanol intake (g/kg body weight) did not differ between genotypes, while body weights (20-25%) and water intake (50%) were elevated in 5-HT(1B) receptor knockout mice.	Water	100-105	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	136-153
10995295-7	2000	Endogenous LPO in unpasteurized milk was activated at 25 degrees C by adding 1 mM H(2)O(2).	Water	82-87	lactoperoxidase	Homo sapiens	11-14
10946299-8	2000	We found that phenol/water-extracts of the two strains use TLRs differently with T. brennaborense-stimulating cells in a TLR-4-dependent fashion, while T. maltophilum-mediated activation apparently involved TLR-2.	Water	21-26	Tlr2	Cricetulus griseus	207-212
10974049-4	2000	At the triolein/water interface apolipoprotein A-IV displayed maximal surface activity only at long interface ages, with an adsorption rate constant of 1.0 3 10(-)(3) sec(-)(1), whereas apolipoprotein B-17 lowered interfacial tension even at the shortest interface ages, with an adsorption rate constant of 9.3 3 10(-)(3) sec(-)(1).	Water	16-21	apolipoprotein A4	Homo sapiens	32-51
10974049-5	2000	Apolipoprotein A-IV displayed an expanded conformation at the air/water interface and a biphasic compression isotherm, suggesting that its hydrophilic amphipathic helices move in and out of the interface in response to changes in surface pressure.	Water	66-71	apolipoprotein A4	Homo sapiens	0-19
10959955-7	2000	The increased wetting of the C18 interphase in the order water &lt; methanol &lt; acetonitrile &lt; tetrahydrofuran agreed with data for the miscibility of these solvents with n-hexadecane.	Water	57-62	Bardet-Biedl syndrome 9	Homo sapiens	29-32
10982394-2	2000	For the human aquaporin water channel AQP1, however, the initial four-segment-spanning topology at the ER membrane differs from the mature six-segment-spanning topology at the plasma membrane.	Water	24-29	aquaporin 1 (Colton blood group)	Homo sapiens	38-42
10982394-7	2000	AQP1 topological reorientation was also associated with maturation from a protease-sensitive conformation to a protease-resistant structure with water channel function.	Water	145-150	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
10997721-1	2000	Vasopressin V2-receptor antagonists are promising agents for the use in water-retaining diseases.	Water	72-77	arginine vasopressin receptor 2	Rattus norvegicus	0-23
10933813-4	2000	Thus we describe the tertiary structure of porcine PYY in water at pH 5.5, 25 degrees C, and 150 mM NaCl, as determined from 2D (1)H NMR data recorded at 500 MHz.	Water	58-63	peptide YY	Homo sapiens	51-54
10925260-9	2000	Upon stimulation with dendritic cells in the presence of the water-soluble DNFB analogue, DNBS, CTLA-4+ T cells from DNFB-tolerized mice secreted high levels of IL-10, TGF-beta, and IFN-gamma; low levels of IL-2; and no IL-4, resembling the cytokine pattern of T regulatory 1 cells.	Water	61-66	interleukin 10	Mus musculus	161-166
11039725-6	2000	In contrast, detectable levels of FMRP within the somatosensory cortex show either a decrease or no change after a kainic acid induced seizure compared to water treated controls.	Water	155-160	fragile X messenger ribonucleoprotein 1	Rattus norvegicus	34-38
10925260-9	2000	Upon stimulation with dendritic cells in the presence of the water-soluble DNFB analogue, DNBS, CTLA-4+ T cells from DNFB-tolerized mice secreted high levels of IL-10, TGF-beta, and IFN-gamma; low levels of IL-2; and no IL-4, resembling the cytokine pattern of T regulatory 1 cells.	Water	61-66	interferon gamma	Mus musculus	182-191
10924044-2	2000	We previously demonstrated that H(2)O(2) opens the large-conductance, calcium- and voltage-activated (BK(Ca)) potassium channel of coronary myocytes (2) and now report physiological and biochemical evidence that the effect of H(2)O(2) on coronary smooth muscle involves the phospholipase A(2) (PLA(2))/arachidonic acid (AA) signaling cascades.	Water	32-37	phospholipase A2 group IB	Homo sapiens	274-292
10926515-0	2000	Three-dimensional fold of the human AQP1 water channel determined at 4 A resolution by electron crystallography of two-dimensional crystals embedded in ice.	Water	41-46	aquaporin 1 (Colton blood group)	Homo sapiens	36-40
10924044-2	2000	We previously demonstrated that H(2)O(2) opens the large-conductance, calcium- and voltage-activated (BK(Ca)) potassium channel of coronary myocytes (2) and now report physiological and biochemical evidence that the effect of H(2)O(2) on coronary smooth muscle involves the phospholipase A(2) (PLA(2))/arachidonic acid (AA) signaling cascades.	Water	226-231	phospholipase A2 group IB	Homo sapiens	274-292
11144661-4	2000	For example, the high water permeability of the proximal tubule has been shown to be imparted by the water channel, aquaporin AQP1; however, genetic knockout of this water channel is at least partially compensated by intrarenal feedback mechanisms.	Water	22-27	aquaporin 1 (Colton blood group)	Homo sapiens	126-130
11144661-4	2000	For example, the high water permeability of the proximal tubule has been shown to be imparted by the water channel, aquaporin AQP1; however, genetic knockout of this water channel is at least partially compensated by intrarenal feedback mechanisms.	Water	101-106	aquaporin 1 (Colton blood group)	Homo sapiens	126-130
11144661-4	2000	For example, the high water permeability of the proximal tubule has been shown to be imparted by the water channel, aquaporin AQP1; however, genetic knockout of this water channel is at least partially compensated by intrarenal feedback mechanisms.	Water	101-106	aquaporin 1 (Colton blood group)	Homo sapiens	126-130
10812266-1	2000	Atrial natriuretic peptide (ANP) plays a part in the regulation of volume homeostasis and possibly, in the pathophysiology of water and electrolyte disorder.	Water	126-131	natriuretic peptide A	Homo sapiens	0-26
10960832-7	2000	SYN-2869 was separated from the matrix components on a symmetry C(18) column using a aqueous mobile phase of acetonitrile and water with a flow rate of 1 mL/min.	Water	126-131	joined toes	Mus musculus	0-3
10812266-1	2000	Atrial natriuretic peptide (ANP) plays a part in the regulation of volume homeostasis and possibly, in the pathophysiology of water and electrolyte disorder.	Water	126-131	natriuretic peptide A	Homo sapiens	28-31
11036784-9	2000	The intake with the fodder of some substances such as Fe or NO3- is many times higher than the intake with the water.	Water	111-116	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
10974488-7	2000	The injection of yohimbine (an alpha-2-adrenergic antagonist) and prazosin (an alpha-1-adrenergic antagonist) into the LH, which was done before injecting ANGII into the LV, also reduced the water intake induced by ANGII.	Water	191-196	angiotensinogen	Rattus norvegicus	215-220
10974488-1	2000	The circumventricular structures and the lateral hypothalamus (LH) have been shown to be important for the central action of angiotensin II (ANGII) on water and electrolyte regulation.	Water	151-156	angiotensinogen	Rattus norvegicus	125-139
10974488-1	2000	The circumventricular structures and the lateral hypothalamus (LH) have been shown to be important for the central action of angiotensin II (ANGII) on water and electrolyte regulation.	Water	151-156	angiotensinogen	Rattus norvegicus	141-146
10974488-3	2000	The present experiments were conducted to investigate the role of the alpha-adrenergic antagonists and agonistic injected into the LH on the water intake, sodium and potassium excretion elicited by injections of ANGII into the lateral ventricle (LV).	Water	141-146	angiotensinogen	Rattus norvegicus	212-217
10974488-6	2000	The injection of ANGII into the LV increased the water intake, which was reduced by previous injection of clonidine (an alpha-2-adrenergic agonist) into the LH.	Water	49-54	angiotensinogen	Rattus norvegicus	17-22
11001488-4	2000	This water channel, which is expressed in the renal collecting duct, is redistributed to the apical membrane in response to a intracellular signaling cascade, initiated by binding of the antidiuretic hormone vasopressin to its receptor.	Water	5-10	arginine vasopressin	Homo sapiens	208-219
11126569-4	2000	The amount of Mvp1 mRNA, transcribed from a single gene, is different in E and L seeds after water uptake.	Water	93-98	GDSL-like Lipase/Acylhydrolase superfamily protein	Arabidopsis thaliana	14-18
10946007-5	2000	In RFASMC, catalase protein, mRNA, and the enzyme activity are increased in response to oxidized linoleic acid (13-hydroperoxy-9,11-octadecadienoic acid [13-HPODE] and 13-hydroxy-9,11-octadecadienoic acid [13-HODE]), MO-LDL, or hydrogen peroxide (H(2)O(2)).	Water	247-252	catalase	Homo sapiens	11-19
10956090-1	2000	The paper describes the relationship between the physicochemical characteristics of model oi-in-water emulsion systems containing oil droplets and soluble fragments (monomers and micelles) and the activity of pure soybean lipoxygenase 1.	Water	96-101	seed linoleate 13S-lipoxygenase-1	Glycine max	222-236
11185650-2	2000	The ethanol-fed rats drank ethanol (5 to 30% vol/vol) in tap water for 5 wk.	Water	61-66	nuclear RNA export factor 1	Rattus norvegicus	57-60
10962518-1	2000	Both leptin and the renin-angiotensin system (RAS) can influence the activity of the sympathetic nervous system, water and electrolyte metabolism as well as vascular remodelling, which are all involved in the regulation of arterial blood pressure.	Water	113-118	renin	Homo sapiens	20-25
10961544-3	2000	There are three aspartame molecules and two water molecules in the asymmetric unit of the monoclinic space group P2(1).	Water	44-49	cyclin dependent kinase inhibitor 1A	Homo sapiens	113-118
10910438-1	2000	BACKGROUND: It has been suggested that urinary excretion of the vasopressin-dependent water channel of the kidney collecting duct, aquaporin-2 (AQP2), reflects renal vasopressin action and might be used clinically.	Water	86-91	arginine vasopressin	Homo sapiens	64-75
10910438-1	2000	BACKGROUND: It has been suggested that urinary excretion of the vasopressin-dependent water channel of the kidney collecting duct, aquaporin-2 (AQP2), reflects renal vasopressin action and might be used clinically.	Water	86-91	arginine vasopressin	Homo sapiens	166-177
10930459-2	2000	Thioredoxin peroxidase, Tsa1p, of the thioredoxin system, was found to be essential for the transcriptional induction of other components of the thioredoxin system, TRX2 (thioredoxin) and TRR1 (thioredoxin reductase), in response to H(2)O(2).	Water	233-238	thioredoxin TRX2	Saccharomyces cerevisiae S288C	165-169
11056378-5	2000	The water treated by igneous rock, both directly soaked or indirectly in contact, induced increased activities of glucose oxidase, catalase, peroxidase, and superoxide dismutase.	Water	4-9	catalase	Homo sapiens	131-139
10891268-1	2000	The lens major intrinsic protein (MIP, AQP0) is known to function as a water and solute channel.	Water	71-76	major intrinsic protein of lens fiber	Homo sapiens	39-43
10801894-5	2000	Catalase blocked ERK activation by H(2)O(2), but not by ONOO(-), demonstrating that the effect of ONOO(-) was not due to the generation of H(2)O(2).	Water	35-40	catalase	Rattus norvegicus	0-8
10801894-5	2000	Catalase blocked ERK activation by H(2)O(2), but not by ONOO(-), demonstrating that the effect of ONOO(-) was not due to the generation of H(2)O(2).	Water	35-40	Eph receptor B1	Rattus norvegicus	17-20
11196900-1	2000	A variety of lariat ethers were employed to solubilize water-soluble cytochrome c in methanol, in which alcohol, ether, ester, amine, and amide functionalities were attached as cation-ligating side arms to 18-crown-6, 15-crown-5, and 12-crown-4 rings.	Water	55-60	cytochrome c, somatic	Homo sapiens	69-81
10926680-0	2000	Water permeability in rat oocytes at different maturity stages: aquaporin-9 expression.	Water	0-5	aquaporin 9	Rattus norvegicus	64-75
10926680-10	2000	AQP9 has been recently described as a "broad selective channel" responsible for solute and water transfers in highly active cells.	Water	91-96	aquaporin 9	Rattus norvegicus	0-4
10905295-3	2000	Kinetic studies revealed that the aquation of iridium complexes activated them toward the oxidation of insulin in acidic solutions; e.g., the rate constant was equal to 25, 900, and 8,400 L mol(-1) s(-1) for the oxidation of insulin by the IrCl62-, Ir(H2O)CI5-, and Ir(H2O)2Cl4 complexes, respectively.	Water	252-255	insulin	Homo sapiens	103-110
10825558-4	2000	The efficiency of lysozyme entrapment by a double emulsion method was found to depend on the swelling behavior of the polymers in water and decreased from 100% for polymers with a degree of swelling of less than 1.8 to 11% for PEG-PBT copolymers with a degree of swelling of 3.6.	Water	130-135	lysozyme	Homo sapiens	18-26
10898713-7	2000	H(2)O(2) mediates changes in ERK1/ERK2 phosphorylation, increases endothelial solute permeability, and alters occludin localization and phosphorylation were all blocked by PD-98059, a specific mitogen-activated protein (MAP) or ERK kinase 1 inhibitor.	Water	0-5	mitogen-activated protein kinase 3	Homo sapiens	29-33
10898713-7	2000	H(2)O(2) mediates changes in ERK1/ERK2 phosphorylation, increases endothelial solute permeability, and alters occludin localization and phosphorylation were all blocked by PD-98059, a specific mitogen-activated protein (MAP) or ERK kinase 1 inhibitor.	Water	0-5	mitogen-activated protein kinase 1	Homo sapiens	34-38
10894793-9	2000	Our results suggest that renal medullary synthesized ET-1 may be a natriuretic factor and may participate in the intrarenal regulation of water and salt homeostasis in prehypertensive DOCA-and salt-treated rats.	Water	138-143	endothelin 1	Rattus norvegicus	53-57
10905295-3	2000	Kinetic studies revealed that the aquation of iridium complexes activated them toward the oxidation of insulin in acidic solutions; e.g., the rate constant was equal to 25, 900, and 8,400 L mol(-1) s(-1) for the oxidation of insulin by the IrCl62-, Ir(H2O)CI5-, and Ir(H2O)2Cl4 complexes, respectively.	Water	252-255	insulin	Homo sapiens	225-232
10933509-4	2000	Well-ordered crystals of the water channel human aquaporin-1 (hAQP1) that diffract to 4 A resolution have been obtained with this approach.	Water	29-34	aquaporin 1 (Colton blood group)	Homo sapiens	49-60
11710113-2	2000	Cytochrome c and rGPIb alpha; a water-soluble fragment of the alpha chain of a recombinant platelet glycoprotein (GP)Ib containing a von Willebrand factor (vWf)-binding site were selected as a receptor protein.	Water	32-37	von Willebrand factor	Homo sapiens	156-159
10860590-2	2000	Sodium [(99m)Tc]pertechnetate was employed as the imaging agent and served as a marker for the amount of water present in the foam during the foam fractionation of bovine serum albumin.	Water	105-110	albumin	Homo sapiens	171-184
10909962-0	2000	Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.	Water	153-156	insulin	Homo sapiens	42-49
10943948-6	2000	The concentrations of various cations of water in this ecosystem were in the order of Na+ &gt; Mg2+ &gt; K+ = Ca2+, and those of anions of water were in the order of Cl- &gt; SO4(2-) &gt; NO3- &gt; PO4(3-).	Water	41-46	NBL1, DAN family BMP antagonist	Homo sapiens	188-191
10933509-4	2000	Well-ordered crystals of the water channel human aquaporin-1 (hAQP1) that diffract to 4 A resolution have been obtained with this approach.	Water	29-34	aquaporin 1 (Colton blood group)	Homo sapiens	62-67
10909728-3	2000	The differences in the NO2-/NO3- ratio found between various studies can be satisfactorily explained though a mechanism where HNO2 and HNO3 are formed in the gas phase of the imploding cavity, and then dissolve in the water and dissociate to ions.	Water	218-223	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
10909729-2	2000	The rate of OH radical formation from water is 19.8 microM min-1 under argon and 14.7 microM min-1 under air in the same sonolysis conditions.	Water	38-43	CD59 molecule (CD59 blood group)	Homo sapiens	59-64
10909729-2	2000	The rate of OH radical formation from water is 19.8 microM min-1 under argon and 14.7 microM min-1 under air in the same sonolysis conditions.	Water	38-43	CD59 molecule (CD59 blood group)	Homo sapiens	93-98
18967999-6	2000	The developed method was applied to Co(II) determination in potable water.	Water	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
10903416-5	2000	Hypophysectomy-induced increase in the CYP2E1 mRNA was completely abolished by glucose feeding in drinking water (10%) for 7 days.	Water	107-112	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	39-45
10764744-11	2000	These results suggest that catalase, overexpressed in the cytosolic or especially the mitochondrial compartment, potentiates TNF-alpha-induced apoptosis and activation of caspases by removal of H(2)O(2).	Water	194-199	tumor necrosis factor	Homo sapiens	125-134
10873606-2	2000	Like the kidney, the eye contains multiple water channel proteins (aquaporins) that transport water through membranes, including two (AQP1 and AQP4) in the ciliary body, the site of aqueous humor production.	Water	43-48	aquaporin 1 (Colton blood group)	Homo sapiens	134-138
10873606-3	2000	Previous results from our laboratory demonstrated that water channel activity of AQP1 was significantly increased by protein kinase A (PKA) activators such as cyclic-AMP (cAMP) and forskolin.	Water	55-60	aquaporin 1 (Colton blood group)	Homo sapiens	81-85
10873606-4	2000	The purpose of this study is to determine whether PKA-dependent protein phosphorylation is involved in the regulation of water channel activity of AQP1.	Water	121-126	aquaporin 1 (Colton blood group)	Homo sapiens	147-151
10873606-8	2000	In addition, they suggest important potential roles for AQP1 in several clinical disorders involving rapid water transport such as glaucoma.	Water	107-112	aquaporin 1 (Colton blood group)	Homo sapiens	56-60
10841753-3	2000	In the study presented here, (113)Cd magic-angle spinning solid-state NMR spectroscopy is used to probe the Ca(2+)-binding site in the water-oxidizing complex of (113)Cd(2+)-substituted PS2.	Water	135-140	taste 2 receptor member 64 pseudogene	Homo sapiens	186-189
10828976-6	2000	In the folded state, both side chains are involved in the "solvation of the same water molecule WAT1.	Water	81-86	MTOR associated protein, LST8 homolog	Homo sapiens	96-100
10848527-2	2000	The hypothesis was therefore tested that an increase in arterial pulse pressure is the stimulus for suppression of AVP release during central blood volume expansion by water immersion.	Water	168-173	arginine vasopressin	Homo sapiens	115-118
10963933-8	2000	In the single fluid access (one-bottle) test, nicotine-treated mice consumed both more ethanol (2%, 4%, or 6% concentrations) and more tap water than control mice.	Water	139-144	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	135-138
10963934-8	2000	All these effects underline the crucial role played by catalase which, on one hand converts hydrogen peroxide to water and, on the other hand, ethanol to acetaldehyde.	Water	113-118	catalase	Homo sapiens	55-63
10864891-0	2000	Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock.	Water	36-41	poly(ADP-ribose) polymerase 1	Homo sapiens	87-115
10864891-2	2000	Here we report on (i) a new synthesis of a water-soluble and potent PARP inhibitor, 5-aminoisoquinolinone (5-AIQ) and (ii) investigate the effects of 5-AIQ on the circulatory failure and the organ injury/dysfunction caused by haemorrhage and resuscitation in the anaesthetized rat.	Water	43-48	poly(ADP-ribose) polymerase 1	Homo sapiens	68-72
10938462-1	2000	We have examined the release of H(2)O(2) from PAF or TNFalpha-stimulated human eosinophils on fibronectin (FN)-coated polystyrene plates.	Water	32-37	tumor necrosis factor	Homo sapiens	53-61
11050685-0	2000	Vasopressin and A1 noradrenaline turnover during food or water deprivation in the rat.	Water	57-62	arginine vasopressin	Rattus norvegicus	0-11
11050682-2	2000	Also, a decrease in the water soluble antioxidant mechanism reflected in the activities of the enzymes superoxide dismutase (SOD), catalase and the glutathione peroxidase (GTPx) was found in the liver but not in the kidney.	Water	24-29	catalase	Rattus norvegicus	131-139
10938462-1	2000	We have examined the release of H(2)O(2) from PAF or TNFalpha-stimulated human eosinophils on fibronectin (FN)-coated polystyrene plates.	Water	32-37	fibronectin 1	Homo sapiens	94-105
10940221-0	2000	The Alzheimer"s peptide a beta adopts a collapsed coil structure in water.	Water	68-73	amyloid beta precursor protein	Homo sapiens	24-30
10825386-6	2000	It is also repressed by the transfection of a CYP2E1 expression vector, which elicits an intracellular H(2)O(2) generation.	Water	103-108	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	46-52
29544011-3	2000	The results of 4-h incubations just below the water surface show that, compared with ambient UVBR conditions, UVBR exclusion generally increased NO3- , NH4+ , and urea uptakes.	Water	46-51	NBL1, DAN family BMP antagonist	Homo sapiens	145-148
10847173-6	2000	Denitrification in sediments in both loughs can play a potentially significant role in removal of NO3- from the overlying water.	Water	122-127	NBL1, DAN family BMP antagonist	Homo sapiens	98-101
10880703-7	2000	It is suggested that central 5-HT(4) receptors exert a dualistic role on the control of water intake potentiating angiotensin II-induced drinking and inhibiting thirst induced by central cholinergic activation	Water	88-93	angiotensinogen	Rattus norvegicus	114-128
10806370-0	2000	Induction of oxidative stress and TNF-alpha secretion by dichloroacetonitrile, a water disinfectant by-product, as possible mediators of apoptosis or necrosis in a murine macrophage cell line (RAW).	Water	81-86	tumor necrosis factor	Mus musculus	34-43
10799532-5	2000	In contrast to tunicamycin treatment, water stress condition stimulated phosphorylation of BiP species in soybean cultured cells and stressed leaves.	Water	38-43	ER-binding immunoglobulin protein BIP2	Glycine max	91-94
10779555-12	2000	The NKCC2 mutant animals should be valuable for uncovering new pathophysiologic and therapeutic aspects of genetic disturbances in water and electrolyte recovery by the kidney.	Water	131-136	solute carrier family 12, member 1	Mus musculus	4-9
10794696-6	2000	The first one is important for obtaining bioavailable thrombin inhibitors, devoid of the high basicity of the commonly used arginine/amidine-based inhibitors, whereas the second one may lead to improved water solubility of such compounds due to facilitated metal (sodium) salts formation (at the relatively acidic SO(2)NHCO protons) as well as increased stability at hydrolysis (in vivo).	Water	203-208	coagulation factor II, thrombin	Homo sapiens	54-62
10959011-2	2000	A review of previous studies reveals that ANP is an important regulator of water and nutrient intake, which acts via multiple signaling pathways including activation of guanylyl cyclase to produce its biologic responses.	Water	75-80	natriuretic peptide A	Homo sapiens	42-45
10748080-6	2000	CYP2E1-overexpressing cells showed a 40-50% increase in intracellular H(2)O(2); a 30% increase in total GSH levels; a 50% increase in the GSH synthesis rate; and a 2-fold increase in gamma-glutamylcysteine synthetase heavy subunit (GCS-HS) mRNA, the rate-limiting enzyme in GSH synthesis.	Water	70-75	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
10847161-4	2000	Epilithic leucine aminopeptidase activity and leucine assimilation were both potentially controlled by epilithic microbial variables (bacterial abundance and chlorophyll a) while leucine aminopeptidase activity was also strongly related to water-quality variables, especially temperature, pH and conductivity.	Water	240-245	carboxypeptidase Q	Homo sapiens	187-201
10847178-0	2000	The water quality of a tributary of the Thames, the Pang, southern England.	Water	4-9	contactin 3	Homo sapiens	52-56
10847178-1	2000	The water quality of a tributary of the Thames, the Pang, draining a rural part of the Thames basin is described and related to the influences of inputs from farming activity and groundwater from the underlying chalk aquifer as modified by biological within-stream processes.	Water	4-9	contactin 3	Homo sapiens	52-56
11227442-3	2000	CO2 and water were found to be suitable for the quantitative extraction of all PCB.	Water	8-13	pyruvate carboxylase	Homo sapiens	79-82
10831252-5	2000	This results in a preferential release of vasopressin over oxytocin that promotes conservation of water.	Water	98-103	arginine vasopressin	Homo sapiens	42-53
10775127-1	2000	Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are cardiac hormones that are involved in water and electrolyte homeostasis in heart failure.	Water	111-116	natriuretic peptide B	Rattus norvegicus	37-62
10775127-1	2000	Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are cardiac hormones that are involved in water and electrolyte homeostasis in heart failure.	Water	111-116	natriuretic peptide B	Rattus norvegicus	64-67
10779387-2	2000	For AQP1, inhibition by mercury has been attributed to the formation of a mercaptide bond with cysteine residue 189 found in the putative pore-forming region loop E. Here we show that the nonmercurial compound, tetraethylammonium (TEA) chloride, reduces the water permeability of human AQP1 channels expressed in Xenopus oocytes.	Water	258-263	aquaporin 1 (Colton blood group)	Homo sapiens	4-8
10779387-0	2000	Inhibition of aquaporin-1 water permeability by tetraethylammonium: involvement of the loop E pore region.	Water	26-31	aquaporin 1 (Colton blood group)	Homo sapiens	14-25
10779387-1	2000	Previously, the only known blockers of water permeability through aquaporin-1 (AQP1) water channels were mercurial reagents such as HgCl(2).	Water	39-44	aquaporin 1 (Colton blood group)	Homo sapiens	66-77
10779387-1	2000	Previously, the only known blockers of water permeability through aquaporin-1 (AQP1) water channels were mercurial reagents such as HgCl(2).	Water	39-44	aquaporin 1 (Colton blood group)	Homo sapiens	79-83
10779387-1	2000	Previously, the only known blockers of water permeability through aquaporin-1 (AQP1) water channels were mercurial reagents such as HgCl(2).	Water	85-90	aquaporin 1 (Colton blood group)	Homo sapiens	66-77
10779387-1	2000	Previously, the only known blockers of water permeability through aquaporin-1 (AQP1) water channels were mercurial reagents such as HgCl(2).	Water	85-90	aquaporin 1 (Colton blood group)	Homo sapiens	79-83
10779387-3	2000	After preincubation of the oocytes for 15 min with 100 microM TEA, AQP1 water permeability was reduced by 20 to 40%, a degree of partial block similar to that obtained with 15 min of incubation in 100 microM HgCl(2).	Water	72-77	aquaporin 1 (Colton blood group)	Homo sapiens	67-71
10779387-8	2000	Oocyte expression of the mutant AQP1 channels showed that the water permeability of Y186F was equivalent to that of wild-type AQP1; the other mutant channels did not conduct water.	Water	62-67	aquaporin 1 (Colton blood group)	Homo sapiens	32-36
10779387-8	2000	Oocyte expression of the mutant AQP1 channels showed that the water permeability of Y186F was equivalent to that of wild-type AQP1; the other mutant channels did not conduct water.	Water	174-179	aquaporin 1 (Colton blood group)	Homo sapiens	32-36
10773751-1	2000	Many previous studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine and that the excretion increases in response to vasopressin.	Water	84-89	arginine vasopressin	Homo sapiens	62-73
10779387-10	2000	These results suggest that TEA reduces AQP1 water permeability by interacting with loop E.	Water	44-49	aquaporin 1 (Colton blood group)	Homo sapiens	39-43
10773751-1	2000	Many previous studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine and that the excretion increases in response to vasopressin.	Water	84-89	arginine vasopressin	Homo sapiens	172-183
10845788-2	2000	Raman spectroscopy is used to characterize the behavior of the C18 bonded ligands equilibrated at temperatures from 45 to 2 degrees C in neat, single-component, mobile phase solvents including: water, acetonitrile, methanol, and chloroform.	Water	194-199	Bardet-Biedl syndrome 9	Homo sapiens	63-66
10802646-3	2000	MIP is a member of the aquaporin family of membrane-bound water channels.	Water	58-63	major intrinsic protein of lens fiber	Homo sapiens	0-3
10843238-3	2000	We therefore measured the effect of distilled water-lysed human RBCs on cultured LLC-PK1 cell function.	Water	46-51	pyruvate kinase L/R	Homo sapiens	85-88
10773159-1	2000	The Mn(4) complex which is involved in water oxidation in photosystem II is known to exhibit three types of EPR signals in the S(2) state, one of the five redox states of the enzyme cycle: a multiline signal (spin 1/2), signals at g5 (spin 5/2) and a signal at g=4.1 (or g=4.25).	Water	39-44	spindlin family member 2A	Homo sapiens	235-243
10733927-1	2000	Incubation of myeloperoxidase (MPO) with H(2)O(2) in the presence of the spin trap DBNBS (3,5-dibromo-4-nitrosobenzenesulfonic acid) results in the EPR-detectable formation of a partially immobilized protein radical.	Water	41-46	myeloperoxidase	Homo sapiens	14-29
10737773-1	2000	Aquaporin-3 (AQP3) is a water channel expressed at the basolateral plasma membrane of kidney collecting-duct epithelial cells.	Water	24-29	aquaporin 3	Mus musculus	0-11
10737773-1	2000	Aquaporin-3 (AQP3) is a water channel expressed at the basolateral plasma membrane of kidney collecting-duct epithelial cells.	Water	24-29	aquaporin 3	Mus musculus	13-17
10737773-7	2000	After 1-desamino-8-d-arginine-vasopressin administration or water deprivation, the AQP3 null mice were able to concentrate their urine partially to approximately 30% of that in wild-type mice.	Water	60-65	aquaporin 3	Mus musculus	83-87
10737773-8	2000	Osmotic water permeability of cortical collecting-duct basolateral membrane, measured by a spatial filtering optics method, was &gt;3-fold reduced by AQP3 deletion.	Water	8-13	aquaporin 3	Mus musculus	150-154
10760512-0	2000	Ligand interaction with the purified serotonin transporter in solution and at the air/water interface.	Water	86-91	solute carrier family 6 member 4	Homo sapiens	37-58
10760512-1	2000	The purified serotonin transporter (SERT) was spread at the air/water interface and the effects both of its surface density and of the temperature on its interfacial behavior were studied.	Water	64-69	solute carrier family 6 member 4	Homo sapiens	13-34
10760512-1	2000	The purified serotonin transporter (SERT) was spread at the air/water interface and the effects both of its surface density and of the temperature on its interfacial behavior were studied.	Water	64-69	solute carrier family 6 member 4	Homo sapiens	36-40
10742606-7	2000	We observed three distance populations for bradykinin in water, that merged to two populations when the solvent was trifluoroethanol (TFE).	Water	57-62	kininogen 1	Homo sapiens	43-53
10733927-1	2000	Incubation of myeloperoxidase (MPO) with H(2)O(2) in the presence of the spin trap DBNBS (3,5-dibromo-4-nitrosobenzenesulfonic acid) results in the EPR-detectable formation of a partially immobilized protein radical.	Water	41-46	myeloperoxidase	Homo sapiens	31-34
10751213-1	2000	The amiloride-sensitive epithelial sodium channel (ENaC) and the vasopressin-dependent water channel aquaporin-2 (AQP2) mediate mineralocorticoid-regulated sodium- and vasopressin-regulated water reabsorption, respectively.	Water	87-92	aquaporin-2	Oryctolagus cuniculus	101-112
10751223-7	2000	Our studies reveal the role of vasopressin in long-term regulation of UT1 and UT2 expression during water restriction.	Water	100-105	arginine vasopressin	Rattus norvegicus	31-42
10751227-10	2000	They support a role for oxidants in conveying the stimulatory signal from 5-HT, because 1) chemical antioxidants attenuate the 5-HT signal, 2) oxidants and 5-HT selectively activate ERK to a similar degree, 3) 5-HT produces superoxide and H(2)O(2) in these cells, and 4) a specific enzyme [NAD(P)H oxidase] has been implicated as the source of the ROS, which react selectively downstream of classical PKC.	Water	239-244	Eph receptor B1	Rattus norvegicus	182-185
10751213-1	2000	The amiloride-sensitive epithelial sodium channel (ENaC) and the vasopressin-dependent water channel aquaporin-2 (AQP2) mediate mineralocorticoid-regulated sodium- and vasopressin-regulated water reabsorption, respectively.	Water	87-92	aquaporin-2	Oryctolagus cuniculus	114-118
10751327-1	2000	Aquaporin 2 (AQP2), the vasopressin-regulated water channel, was originally identified in renal collecting duct principal cells.	Water	46-51	arginine vasopressin	Rattus norvegicus	24-35
10751213-9	2000	The differences between rabbits and rats in the distribution patterns of ENaC and AQP2 may explain functional differences in renal salt and water handling between these species.	Water	140-145	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	73-77
10751327-2	2000	However, our recent description of AQP2 in the vas deferens indicated that this water channel may have extra-renal functions, possibly related to sperm concentration in the male reproductive tract.	Water	80-85	arginine vasopressin	Rattus norvegicus	47-50
10733994-1	2000	Water proton spin-lattice relaxation is studied in dilute solutions of bovine serum albumin as a function of magnetic field strength, oxygen concentration, and solvent deuteration.	Water	0-5	albumin	Homo sapiens	78-91
10711969-5	2000	With regard to the similar microporous hollow fiber membranes, a PEO-b-PSF membrane had a dynamic water contact angle of 33 degrees +/- 2 compared to a 111 degrees +/- 3 for a polysulfone membrane.	Water	98-103	insulin like growth factor binding protein 7	Homo sapiens	71-74
11130462-1	2000	The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel controls salt and water transport across epithelial tissues.	Water	98-103	CF transmembrane conductance regulator	Homo sapiens	4-55
11130462-1	2000	The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel controls salt and water transport across epithelial tissues.	Water	98-103	CF transmembrane conductance regulator	Homo sapiens	57-61
11390879-1	2000	The cystic fibrosis gene encodes a chloride channel (CFTR) that regulates transepithelial salt and water transport.	Water	99-104	CF transmembrane conductance regulator	Homo sapiens	53-57
10737528-17	2000	Moreover, knockout mice given L-arginine supplemented water for 2 weeks had even greater cortical thinning than after 1 week or than mice given tap water for 1 to 2 weeks (p&lt;0.05).	Water	148-153	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	144-147
11033692-3	2000	In one form of hyponatremia seen among the elderly, total body sodium content is normal, but water is retained because of increased antidiuretic hormone (ADH) secretion.	Water	93-98	arginine vasopressin	Homo sapiens	132-152
11033692-3	2000	In one form of hyponatremia seen among the elderly, total body sodium content is normal, but water is retained because of increased antidiuretic hormone (ADH) secretion.	Water	93-98	arginine vasopressin	Homo sapiens	154-157
10757171-3	2000	Based on PSD analyses of serine- or threonine-containing bradykinin and its analogs, which have been ethyl-esterified or 18O labeled at their C termini, the [b(k) + H2O] (where k denotes the position adjacent to the left of the Ser/Thr residue) ion is generally thought to be formed by the transfer of the hydroxyl moiety of a serine or threonine residue to the carbonyl group of the residue to its left accompanied by the loss of the remaining C-terminal portion of the peptide.	Water	165-168	kininogen 1	Homo sapiens	57-67
10716998-9	2000	Accordingly, H(2)O(2) and the glutathione-depleting drug buthionine sulfoximine increased to different extents CCR2, CCR5, and CXCR4 mRNA expression.	Water	13-18	C-C motif chemokine receptor 2	Homo sapiens	111-115
10784341-2	2000	Null mutations in the water channel aquaporin 1 (AQP1) or the Na/H exchanger NHE3, two major fluid transporters in the proximal tubule, are states in which a reduction in proximal fluid absorption is accompanied by proportionate decrements in glomerular filtration rate.	Water	22-27	aquaporin 1 (Colton blood group)	Homo sapiens	49-53
10809059-4	2000	At the same time, reduction of Cu(qo)2 x H2O with PPh3 result in entirely different unstable radical spectrum (g = 2.0046) which is further converted to another relatively stable Cu-containing radical signal (g = 2.0052).	Water	41-44	caveolin 1	Homo sapiens	50-54
10715211-4	2000	Sixteen conserved water molecules common to EF-Tu and other G-proteins in the GDP-binding site are described.	Water	18-23	Tu translation elongation factor, mitochondrial	Bos taurus	44-49
10722699-8	2000	In addition, overexpression of thioredoxin restored glucocorticoid receptor action on the alpha-ENaC GRE in the presence of exogenous H(2)O(2).	Water	134-139	nuclear receptor subfamily 3 group C member 1	Homo sapiens	52-75
10722699-8	2000	In addition, overexpression of thioredoxin restored glucocorticoid receptor action on the alpha-ENaC GRE in the presence of exogenous H(2)O(2).	Water	134-139	sodium channel epithelial 1 subunit alpha	Homo sapiens	90-100
10699430-0	2000	A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1).	Water	58-63	superoxide dismutase 1	Homo sapiens	29-49
10710543-1	2000	Prostaglandin E(2) (PGE(2)) antagonizes the action of arginine vasopressin (AVP) on collecting duct water permeability.	Water	100-105	arginine vasopressin	Rattus norvegicus	54-74
10710543-1	2000	Prostaglandin E(2) (PGE(2)) antagonizes the action of arginine vasopressin (AVP) on collecting duct water permeability.	Water	100-105	arginine vasopressin	Rattus norvegicus	76-79
10784090-4	2000	Simulated impulse responses from the system, analogous to tracer water outflow dilution curves, showed flow-limited behavior over a range of flows from about 2 to 5 ml min(-1) g(-1), as is observed for water in the heart in vivo.	Water	202-207	CD59 molecule (CD59 blood group)	Homo sapiens	168-174
10776533-2	2000	It was shown that water with additions of Ca2+, Na+, K+ and Cl- ions preliminarily treated with weak combined constant (42 microT) and low-frequency alternating (0.06 microT) magnetic fields affects the intrinsic fluorescence of bovine serum albumin, the magnitude of the effect being dependent on the frequency of the alternating field and ionic composition of the aqueous salt solution.	Water	18-23	albumin	Homo sapiens	236-249
10702234-0	2000	pH and calcium regulate the water permeability of aquaporin 0.	Water	28-33	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	50-61
10702234-3	2000	Lowering pH to 6.5 increased the water permeability of aquaporin (AQP0) 3.4 +/- 0.4-fold.	Water	33-38	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	66-70
10702234-9	2000	Three different calmodulin inhibitors each increased AQP0 water permeability, suggesting that Ca(2+) may act through calmodulin.	Water	58-63	calmodulin-1	Xenopus laevis	16-26
10702234-9	2000	Three different calmodulin inhibitors each increased AQP0 water permeability, suggesting that Ca(2+) may act through calmodulin.	Water	58-63	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	53-57
10702234-9	2000	Three different calmodulin inhibitors each increased AQP0 water permeability, suggesting that Ca(2+) may act through calmodulin.	Water	58-63	calmodulin-1	Xenopus laevis	117-127
10702234-11	2000	Because the greatest change in AQP0 water permeability is in the normal pH range found in the lens (7.2-6.5), this paper provides evidence for regulation of an aquaporin by pH under physiological conditions.	Water	36-41	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	31-35
18967890-4	2000	A flow-rate of 0.9 ml min(-1) with a water fraction of 0.64 in the ACN-water mixture and a column temperature of 10 degrees C gave the most efficient separation conditions.	Water	37-42	CD59 molecule (CD59 blood group)	Homo sapiens	22-28
10766399-1	2000	Aquaporin-2 (AQP-2) is an arginine vasopressin (AVP)-regulated water channel in renal collecting duct cells.	Water	63-68	arginine vasopressin	Homo sapiens	48-51
10732968-1	2000	The efficient synthesis of a water-soluble C11a-epi-analogue (6b) of quinocarcin is described.	Water	29-34	endogenous retrovirus group K member 25	Homo sapiens	43-47
10677382-1	2000	Atrial natriuretic peptide (ANP) plays an important role in the regulation of blood pressure through sodium-water homoeostasis.	Water	108-113	natriuretic peptide A	Homo sapiens	0-26
10699430-2	2000	Water-soluble tetrazolium, the sodium salt of 4-[3-(4iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-be nzene disulfonate, was used as a detector of superoxide radical generated by xanthine oxidase and hypoxanthine, in the presence of a range of concentrations of superoxide dismutase.	Water	0-5	superoxide dismutase 1	Homo sapiens	267-287
10677382-1	2000	Atrial natriuretic peptide (ANP) plays an important role in the regulation of blood pressure through sodium-water homoeostasis.	Water	108-113	natriuretic peptide A	Homo sapiens	28-31
10694901-8	2000	Osmotic water permeability (P( f)) measurements confirmed that functional AQP1 water channels are expressed in human NPE cells and the P(f) for these cells was 9.8 x 10( -3) cm/s at 10 degrees C. CONCLUSIONS: The presence of AQP1 in human NPE cells suggests that it may have a role in the fluid flow across epithelial membranes.	Water	8-13	aquaporin 1 (Colton blood group)	Homo sapiens	74-78
10694901-8	2000	Osmotic water permeability (P( f)) measurements confirmed that functional AQP1 water channels are expressed in human NPE cells and the P(f) for these cells was 9.8 x 10( -3) cm/s at 10 degrees C. CONCLUSIONS: The presence of AQP1 in human NPE cells suggests that it may have a role in the fluid flow across epithelial membranes.	Water	79-84	aquaporin 1 (Colton blood group)	Homo sapiens	74-78
10694901-8	2000	Osmotic water permeability (P( f)) measurements confirmed that functional AQP1 water channels are expressed in human NPE cells and the P(f) for these cells was 9.8 x 10( -3) cm/s at 10 degrees C. CONCLUSIONS: The presence of AQP1 in human NPE cells suggests that it may have a role in the fluid flow across epithelial membranes.	Water	79-84	aquaporin 1 (Colton blood group)	Homo sapiens	225-229
10749317-0	2000	Discrepancies between effects of recombinant human growth hormone on absorption and secretion of water and electrolytes on the human jejunum compared to results reported on rat jejunum.	Water	97-102	growth hormone 1	Homo sapiens	51-65
10757221-3	2000	In recent years, it has become apparent that endothelin-1 contributes to the regulation of renal salt and water excretion and that it is a major contributor to the hypertension associated with salt-dependency.	Water	106-111	endothelin 1	Homo sapiens	45-57
10681368-3	2000	In this study we demonstrated that 7-hydroxyfluperlapine, the major metabolite of fluperlapine in humans, is oxidized to a reactive intermediate by HOCl and by myeloperoxidase in the presence of H(2)O(2) and Cl(-).	Water	195-200	myeloperoxidase	Homo sapiens	160-175
10749317-1	2000	Previous studies in rats showed that the administration of recombinant human growth hormone markedly increased intestinal absorption of electrolytes and water and suggested that growth hormone would be a useful antidiarrheal agent.	Water	153-158	growth hormone 1	Homo sapiens	77-91
10749317-1	2000	Previous studies in rats showed that the administration of recombinant human growth hormone markedly increased intestinal absorption of electrolytes and water and suggested that growth hormone would be a useful antidiarrheal agent.	Water	153-158	growth hormone 1	Homo sapiens	178-192
10713206-0	2000	Influence of water activity and aqueous solvent ordering on enzyme kinetics of alcohol dehydrogenase, lysozyme, and beta-galactosidase.	Water	13-18	lysozyme	Homo sapiens	102-110
10713206-1	2000	Effects of the water activity (a(w)) and the solvent ordering, as determined by the activity coefficient of water, were investigated on the enzyme kinetics of alcohol dehydrogenase, lysozyme, and beta-galactosidase in various aqueous solutions.	Water	15-20	lysozyme	Homo sapiens	182-190
10751106-11	2000	Plasma renin activity was reduced as during immersion in water at the highest temperature.	Water	57-62	renin	Homo sapiens	7-12
10713206-1	2000	Effects of the water activity (a(w)) and the solvent ordering, as determined by the activity coefficient of water, were investigated on the enzyme kinetics of alcohol dehydrogenase, lysozyme, and beta-galactosidase in various aqueous solutions.	Water	108-113	lysozyme	Homo sapiens	182-190
10795928-15	2000	The acute direct and delayed indirect actions of vasopressin on renal urea transporters will increase medullary urea accumulation and thus the ability of the kidney to conserve water.	Water	177-182	arginine vasopressin	Homo sapiens	49-60
10795926-5	2000	First, physiological elevations of plasma vasopressin concentration seen with 48 h of water restriction reduce blood flow to the inner medulla (via V1 receptors) while maintaining a constancy of blood flow to the outer medulla.	Water	86-91	arginine vasopressin	Rattus norvegicus	42-53
10803477-1	2000	Generalized edema due to water retention is a very rare complication of insulin therapy.	Water	25-30	insulin	Homo sapiens	72-79
10692499-1	2000	Aquaporin-1 (AQP1) is a member of the membrane intrinsic protein (MIP) gene family and is known to provide pathways for water flux across cell membranes.	Water	120-125	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
10684907-9	2000	Finally, Apoe(-/-) mice showed age-dependent increases in food and water intake, stomach and body weights, and decreases in brown and white adipose tissues.	Water	67-72	apolipoprotein E	Mus musculus	9-13
10692499-1	2000	Aquaporin-1 (AQP1) is a member of the membrane intrinsic protein (MIP) gene family and is known to provide pathways for water flux across cell membranes.	Water	120-125	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
10692499-2	2000	We show here that cloned human AQP1 not only mediates water flux but also serves as a cGMP-gated ion channel.	Water	54-59	aquaporin 1 (Colton blood group)	Homo sapiens	31-35
10755752-10	2000	CONCLUSIONS: In order to confirm the diagnosis of ARPKD, RARE-MR urography seems to be a non-invasive imaging tool that shows directly the microcystic dilated water-filled collecting ducts.	Water	159-164	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Homo sapiens	50-55
10713987-1	2000	The kinetics of water penetration and escape in cytochrome c (cyt c) is studied by molecular dynamics (MD) simulations at various temperatures.	Water	16-21	cytochrome c, somatic	Homo sapiens	48-60
10763585-2	2000	A water extract (500 mg/kg/day, one week administration) of the leaves of A. venetum showed protective effects against carbon tetrachloride (CCl4, 30 microliters/mouse) or D-galactosamine (D-GalN, 700 mg/kg)/lipopolysaccharide (LPS, 20 micrograms/kg)-induced liver injury in mice.	Water	2-7	galanin and GMAP prepropeptide	Mus musculus	191-195
10694534-9	2000	LPS-induced pulmonary leukocyte infiltration and increases in lung water content were also significantly attenuated in Tg mice.	Water	67-72	toll-like receptor 4	Mus musculus	0-3
10681509-9	2000	Amplification of ethanol effects on MII formation and acyl chain packing by osmolytes suggests that ethanol increases the equilibrium concentration of MII both by disordering acyl chain packing and by disrupting rhodopsin-water hydrogen bonds, demonstrating a direct effect of ethanol on rhodopsin.	Water	222-227	rhodopsin	Homo sapiens	212-221
12212263-0	2000	[Derivative-ratio derivative spectrum method for determining nitrate and nitrite radicals (NO3- and NO2-) in environmental water].	Water	123-128	NBL1, DAN family BMP antagonist	Homo sapiens	91-94
12212263-4	2000	The results suggest that this method is better than ratio derivative spectrum method and it can be applied for determining nitrate and nitrite (NO3- and NO2-) in environment water samples.	Water	174-179	NBL1, DAN family BMP antagonist	Homo sapiens	144-147
10679488-5	2000	However, cotreatment with paraquat and either Cu(2+)/Zn(2+) superoxide dismutase or the superoxide dismutase mimetic tetrakis(4-benzoic acid)porphyrin chloride increased eNOS mRNA by 2.3- and 2.2-fold, respectively, implicating a role for H(2)O(2).	Water	239-244	nitric oxide synthase 3	Bos taurus	170-174
10662512-4	2000	The oppositely charged bovine serum albumin (BSA)-DOTAC-water system forms only a large, clear solution phase and a narrow, bluish solution region within a very limited surfactant concentration range.	Water	56-61	albumin	Homo sapiens	30-43
10713987-1	2000	The kinetics of water penetration and escape in cytochrome c (cyt c) is studied by molecular dynamics (MD) simulations at various temperatures.	Water	16-21	cytochrome c, somatic	Homo sapiens	62-67
10656833-1	2000	Human catalase is an heme-containing peroxisomal enzyme that breaks down hydrogen peroxide to water and oxygen; it is implicated in ethanol metabolism, inflammation, apoptosis, aging and cancer.	Water	94-99	catalase	Homo sapiens	6-14
10656833-3	2000	5 A resolution human enzyme structure, both with and without bound NADPH, establishes the conserved features of mammalian catalase fold and assembly, implicates Tyr370 as the tyrosine radical, suggests the structural basis for redox-sensitive binding of cognate mRNA via the catalase NADPH binding site, and identifies an unexpectedly substantial number of water-mediated domain contacts.	Water	357-362	catalase	Homo sapiens	122-130
10642194-0	2000	Hubble Space Telescope and Very Large Array Observations of the H2O Gigamaser Galaxy TXS 2226-184.	Water	64-67	thromboxane A synthase 1	Homo sapiens	85-88
10713987-3	2000	Water molecules in the interior of cyt c have 0-3 water molecules in their first hydration shell and this coordination number persists for extended periods of time.	Water	0-5	cytochrome c, somatic	Homo sapiens	35-40
10713987-3	2000	Water molecules in the interior of cyt c have 0-3 water molecules in their first hydration shell and this coordination number persists for extended periods of time.	Water	50-55	cytochrome c, somatic	Homo sapiens	35-40
10841144-6	2000	Use of vasopressin analogues to induce water retention in elderly patients with nocturnal polyuria is illogical and potentially hazardous; nocturia can be more safely alleviated by diuretic therapy.	Water	39-44	arginine vasopressin	Homo sapiens	7-18
10652212-5	2000	[(3)H] water method was employed to measure Arom activity.	Water	7-12	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	44-48
10660595-6	2000	We propose that in addition to Glu-145 in mouse MPG, which functions as the activator of a water molecule for nucleophilic attack, Asp-152 plays an essential role either by donating a proton to the substrate base and, thus, facilitating its release or by stabilizing the steric configuration of the active site pocket.	Water	91-96	N-methylpurine-DNA glycosylase	Mus musculus	48-51
10664478-2	2000	The oral absorption of ABPP is poor because its low solubility in water.	Water	66-71	amyloid beta precursor protein	Homo sapiens	23-27
10662729-10	2000	Because rats with common bile duct ligation (CBL) have a reduced vasopressin-mediated water reabsorption compared with normal rats (V: -24%; C(H(2)O): -28%, and 86% downregulation of AQP2), the effect of canrenoate combined with OPC-31260 was tested.	Water	86-91	arginine vasopressin	Rattus norvegicus	65-76
10662729-13	2000	This strongly supports the view that aldosterone plays a significant role for vasopressin-mediated water reabsorption.	Water	99-104	arginine vasopressin	Rattus norvegicus	78-89
10713556-4	2000	The interaction of PDSG with catalase in water and in phosphate buffer was accompanied by significant changes in CD spectra in the far UV-region that indicated disturbances in the secondary structure of catalase subunits induced by the bioantioxidant; the latter was suggested to initiate the reaction of thiol--disulfide exchange with the enzyme.	Water	41-46	catalase	Homo sapiens	29-37
10662724-5	2000	RT-PCR of microdissected segments showed that the water channel aquaporin-1 (AQP1) and the urea transporter UT-A2 were expressed in pure DTL, but not in pure ATL, and in DTL-type, but not in ATL-type, regions of mixed-type thin limbs.	Water	50-55	aquaporin 1 (Colton blood group)	Homo sapiens	77-81
10662729-0	2000	Decreased vasopressin-mediated renal water reabsorption in rats with chronic aldosterone-receptor blockade.	Water	37-42	arginine vasopressin	Rattus norvegicus	10-21
10662729-1	2000	Previous studies have suggested that mineralocorticoids are needed for a normal action of vasopressin on collecting duct osmotic water permeability.	Water	129-134	arginine vasopressin	Rattus norvegicus	90-101
10655141-8	2000	Western blot shows that LEP503 is present as a specific approximately 6.9 kDa band in the water-insoluble-urea-soluble fraction of lens cortex where lens epithelium is included.	Water	90-95	lens epithelial protein	Rattus norvegicus	24-30
10664478-3	2000	The purpose of this study is to develop a technological procedure useful to increase the water solubility of ABPP.	Water	89-94	amyloid beta precursor protein	Homo sapiens	109-113
10664478-4	2000	To this end, the interaction of ABPP with several cyclodextrin derivatives-alpha-, beta-, gamma- and hydroxypropyl-beta-cyclodextrin with a degree of substitution 2.7 (HPbetaCD) was studied and the effect of the complexation process on the water solubility of the drug was evaluated.	Water	240-245	amyloid beta precursor protein	Homo sapiens	32-36
10659020-7	2000	The in vivo degradability of the hydrogels, which varied according to water content, played an important role in skull bone regeneration induced by TGFbeta1 -hydrogels.	Water	70-75	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	148-156
10718175-2	2000	Angiotensin II (A II) is well-known in the systemic control of water and electrolyte homeostasis and haemodynamics, but recent evidence points to an additional local renin-angiotensin system (RAS) with possible long-term trophic effects including carcinogenesis.	Water	63-68	angiotensinogen	Homo sapiens	0-14
10718175-2	2000	Angiotensin II (A II) is well-known in the systemic control of water and electrolyte homeostasis and haemodynamics, but recent evidence points to an additional local renin-angiotensin system (RAS) with possible long-term trophic effects including carcinogenesis.	Water	63-68	angiotensinogen	Homo sapiens	16-20
10709930-6	2000	Lysine uptake occurred by a transport mechanism with a Km of approximately 1.4 mM and a Vmax of 7.9 mmol x kg cell water(-1) x 30 min(-1).	Water	115-120	CD59 molecule (CD59 blood group)	Homo sapiens	130-136
10740356-10	2000	Contrary to other sanitization concepts all secondary-contaminated PCB materials were also removed with a high-pressure water method specially developed for such cases.	Water	120-125	pyruvate carboxylase	Homo sapiens	67-70
10675364-1	2000	The CFTR Cl(-) channel controls salt and water transport across epithelial tissues.	Water	41-46	CF transmembrane conductance regulator	Homo sapiens	4-8
11450080-4	2000	The first tested the effect of intracerebral infusion of a small dose (1 U) of thrombin on brain water content.	Water	97-102	coagulation factor II, thrombin	Homo sapiens	79-87
11272543-5	2000	[1]3+ was converted to an aza-capped Co4(III)Zn4(II) octanuclear complex, [Zn4O[Co(L)]4]6+ ([2]6+), by reaction with I- in the presence of Zn2+ and ZnO in water.	Water	155-160	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	41-44
11272543-9	2000	Treatment of [2]6+ with a basic aqueous solution resulted in a cleavage of the Zn-S bonds to produce an aza-capped Co(III) mononuclear complex, [Co(L)] ([3]), from which [1]3+ is readily reproduced by the reaction with Ag+ in water.	Water	226-231	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	115-122
10606771-0	2000	Temperature-dependent beta-sheet formation in beta-amyloid Abeta(1-40) peptide in water: uncoupling beta-structure folding from aggregation.	Water	82-87	amyloid beta precursor protein	Homo sapiens	59-64
10790760-5	2000	As cardiac diseases progress, the heart dilates, plasma norepinephrine increases, atrial natriuretic factor is released and the renin-angiotensin-aldosterone system is suppressed to maintain water and sodium excretion.	Water	191-196	renin	Homo sapiens	128-133
10790760-7	2000	In more advanced stages, atrial natriuretic factor suppression of the renin-angiotensin-aldosterone system is overridden by overt sympathetic activation and sodium and water retention ensues.	Water	168-173	renin	Homo sapiens	70-75
11046433-2	2000	This model is appropriate for supercooled water where the cage effect is dominant and the existence of an alpha relaxation is evident from molecular-dynamics (MD) simulation data of extended simple point charge (SPC/E) model water.	Water	225-230	proline rich protein gene cluster	Homo sapiens	212-215
10654625-1	2000	In the current study, a novel role for the microfilaments in vasopressin-induced water transport in toad urinary bladders, a popular model for the mammalian collecting duct, was established.	Water	81-86	arginine vasopressin	Homo sapiens	61-72
10654625-2	2000	Vasopressin-induced water transport was not affected by cytochalasin D (CD, 20 microM) or latrunculin B (Lat B, 0.5-2 microM), microfilament-disrupting reagents, suggesting that the initial trafficking of vesicles containing water channels and insertion of membranes into the apical membrane are microfilament-independent.	Water	20-25	arginine vasopressin	Homo sapiens	0-11
10654625-2	2000	Vasopressin-induced water transport was not affected by cytochalasin D (CD, 20 microM) or latrunculin B (Lat B, 0.5-2 microM), microfilament-disrupting reagents, suggesting that the initial trafficking of vesicles containing water channels and insertion of membranes into the apical membrane are microfilament-independent.	Water	225-230	arginine vasopressin	Homo sapiens	0-11
10636892-1	2000	Cytochrome c oxidase, the terminal enzyme in the electron transfer chain, catalyzes the reduction of oxygen to water in a multiple step process by utilizing four electrons from cytochrome c.	Water	111-116	cytochrome c, somatic	Homo sapiens	0-12
10636892-1	2000	Cytochrome c oxidase, the terminal enzyme in the electron transfer chain, catalyzes the reduction of oxygen to water in a multiple step process by utilizing four electrons from cytochrome c.	Water	111-116	cytochrome c, somatic	Homo sapiens	177-189
10631021-1	2000	The phase diagram of the ternary surfactant system tetradecyldimethylamine oxide (TDMAO)/HCl/1-hexanol/water shows with increasing cosurfactant concentration an L(1) phase, two L(alpha) phases (a vesicle phase L(alpha1) and a stacked bilayer phase L(alphah)), and an L(3) phase, which are separated by the corresponding two-phase regions L(1)/L(alpha) and L(alpha)/L(3).	Water	103-108	Brown hair color	Homo sapiens	89-94
10648896-8	2000	In contrast, SHSY5Y cells exhibit a much stronger JNK1 activation accompanied with a higher degree in cell death after exposure to H(2)O(2).	Water	131-136	mitogen-activated protein kinase 8	Homo sapiens	50-54
10681016-4	2000	A C18 solid-phase mini-column was used for the pre-concentration, allowing a 12-fold enrichment (as an average value) of the pesticides from fortified water samples.	Water	151-156	Bardet-Biedl syndrome 9	Homo sapiens	2-5
10691781-7	2000	In the gastrointestinal tract, physiological quantities of ANG II stimulate the AT2 receptor releasing NO and cGMP leading to increased sodium and water absorption.	Water	147-152	angiotensinogen	Homo sapiens	59-65
11045315-12	2000	Our results suggest that AQP-1 and AQP-4 may be important factors in water transport in patients undergoing CAPD.	Water	69-74	aquaporin 1 (Colton blood group)	Homo sapiens	25-30
10644652-6	2000	Several of the mammalian aquaporins (e.g., AQP1, AQP2, AQP4, and AQP5) appear to be highly selective for the passage of water, whereas others (recently termed aquaglyceroporins) also transport glycerol (e.g., AQP3 and AQP8) and even larger solutes (AQP9).	Water	120-125	aquaporin 1 (Colton blood group)	Homo sapiens	43-47
11193601-8	2000	Recent work suggests a more direct link between Na+, glucose, and water transport; that is, water is cotransported along with Na+ and sugar through SGLT1.	Water	66-71	solute carrier family 5 member 1	Homo sapiens	148-153
11193820-1	2000	Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide that has several functions, including the regulation of water and electrolyte secretion, hormone and cytokine release, bronchodilitation, and neurogenesis.	Water	119-124	vasoactive intestinal peptide	Homo sapiens	31-34
11193601-8	2000	Recent work suggests a more direct link between Na+, glucose, and water transport; that is, water is cotransported along with Na+ and sugar through SGLT1.	Water	92-97	solute carrier family 5 member 1	Homo sapiens	148-153
10639082-7	2000	We found that conjugates with polyanionic/EAK-[C(110-121)] or polycationic/SAK-[C(110-121)], AK-[C(110-121)]/character were capable to form monomolecular layers at the air/water interface with structure dependent stability in the following order: EAK-[C(110-121)] &gt; SAK-[C(110-121)] &gt; AK-[C(110-121)].	Water	172-177	polo like kinase 4	Homo sapiens	75-78
10912628-1	2000	Glycophorin A (GPA), the major sialoglycoprotein of human erythrocyte membranes, was isolated separately from blood group A and B erythrocytes using phenol-water extraction.	Water	156-161	glycophorin A (MNS blood group)	Homo sapiens	0-19
10639082-7	2000	We found that conjugates with polyanionic/EAK-[C(110-121)] or polycationic/SAK-[C(110-121)], AK-[C(110-121)]/character were capable to form monomolecular layers at the air/water interface with structure dependent stability in the following order: EAK-[C(110-121)] &gt; SAK-[C(110-121)] &gt; AK-[C(110-121)].	Water	172-177	polo like kinase 4	Homo sapiens	269-272
10766956-1	2000	We used 206.5-nm excited resonance Raman measurements to examine the angiotensin II (AII) secondary structure in H(2)O in the presence of dodecylphosphocholine (DPC) micelles, sodium dodecylsulfate (SDS) monomers and micelles, and in a 70% acetonitrile (ACN-d)-30% water solution.	Water	113-118	angiotensinogen	Homo sapiens	69-83
11237202-3	2000	Furthermore, treatment with 0.1% green tea extract in drinking water reduced TNF-alpha gene expression as well as TNF-alpha protein level in the lung of TNF-alpha transgenic mice; and IL-1beta and IL-10 gene expression in the lung was also inhibited by treatment with green tea extract, indicating that green tea inhibits both TNF-alpha and the cytokines induced by TNF-alpha in organs.	Water	63-68	tumor necrosis factor	Mus musculus	77-86
11237202-3	2000	Furthermore, treatment with 0.1% green tea extract in drinking water reduced TNF-alpha gene expression as well as TNF-alpha protein level in the lung of TNF-alpha transgenic mice; and IL-1beta and IL-10 gene expression in the lung was also inhibited by treatment with green tea extract, indicating that green tea inhibits both TNF-alpha and the cytokines induced by TNF-alpha in organs.	Water	63-68	tumor necrosis factor	Mus musculus	114-123
11237202-3	2000	Furthermore, treatment with 0.1% green tea extract in drinking water reduced TNF-alpha gene expression as well as TNF-alpha protein level in the lung of TNF-alpha transgenic mice; and IL-1beta and IL-10 gene expression in the lung was also inhibited by treatment with green tea extract, indicating that green tea inhibits both TNF-alpha and the cytokines induced by TNF-alpha in organs.	Water	63-68	tumor necrosis factor	Mus musculus	114-123
11237202-3	2000	Furthermore, treatment with 0.1% green tea extract in drinking water reduced TNF-alpha gene expression as well as TNF-alpha protein level in the lung of TNF-alpha transgenic mice; and IL-1beta and IL-10 gene expression in the lung was also inhibited by treatment with green tea extract, indicating that green tea inhibits both TNF-alpha and the cytokines induced by TNF-alpha in organs.	Water	63-68	tumor necrosis factor	Mus musculus	114-123
11237202-3	2000	Furthermore, treatment with 0.1% green tea extract in drinking water reduced TNF-alpha gene expression as well as TNF-alpha protein level in the lung of TNF-alpha transgenic mice; and IL-1beta and IL-10 gene expression in the lung was also inhibited by treatment with green tea extract, indicating that green tea inhibits both TNF-alpha and the cytokines induced by TNF-alpha in organs.	Water	63-68	tumor necrosis factor	Mus musculus	114-123
10904236-5	2000	The renin-angiotensin system (RAS), through the important effector peptide, angiotensin II (Ang II), has potent effects on blood pressure, salt and water homeostasis, and target-organ damage.	Water	148-153	angiotensinogen	Homo sapiens	76-90
10904236-5	2000	The renin-angiotensin system (RAS), through the important effector peptide, angiotensin II (Ang II), has potent effects on blood pressure, salt and water homeostasis, and target-organ damage.	Water	148-153	angiotensinogen	Homo sapiens	92-98
10766956-1	2000	We used 206.5-nm excited resonance Raman measurements to examine the angiotensin II (AII) secondary structure in H(2)O in the presence of dodecylphosphocholine (DPC) micelles, sodium dodecylsulfate (SDS) monomers and micelles, and in a 70% acetonitrile (ACN-d)-30% water solution.	Water	113-118	angiotensinogen	Homo sapiens	85-88
11122720-1	2000	The cytochrome P450 (CYP) is a group of enzymes that oxidatively modify drugs to a more water-soluble form for renal excretion.	Water	88-93	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-19
10705470-1	2000	Arginine vasopressin (AVP) has a dual action mainly in the periphery, i.e., vasoconstriction and water reabsorption via V1A and V2 receptors; it may play a role in a number of diseases, including congestive heart failure (CHF), hypertension, renal disease, edema, and hyponatremia.	Water	97-102	arginine vasopressin	Homo sapiens	9-20
10705470-1	2000	Arginine vasopressin (AVP) has a dual action mainly in the periphery, i.e., vasoconstriction and water reabsorption via V1A and V2 receptors; it may play a role in a number of diseases, including congestive heart failure (CHF), hypertension, renal disease, edema, and hyponatremia.	Water	97-102	arginine vasopressin	Homo sapiens	22-25
10654821-6	2000	EP1 and EP3 messenger RNA expression predominate in the collecting duct and thick limb, respectively, where their stimulation reduces sodium chloride and water absorption, promoting natriuresis and diuresis.	Water	154-159	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	0-3
11122720-1	2000	The cytochrome P450 (CYP) is a group of enzymes that oxidatively modify drugs to a more water-soluble form for renal excretion.	Water	88-93	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-24
10614652-5	2000	This receptor down-regulation began by day 2 of water loading, which correlated with the initiation of renal vasopressin escape; by day 3 of water loading, vasopressin V2 receptor expression fell to 43% of DDAVP-treated levels.	Water	141-146	arginine vasopressin receptor 2	Rattus norvegicus	156-179
10695605-7	2000	The time course of SGLT1 protein expression corresponded with that of increased Na+ and water absorption.	Water	88-93	solute carrier family 5 member 1	Canis lupus familiaris	19-24
10614652-4	2000	Water loading induced a marked further down-regulation of vasopressin V2 receptor binding.	Water	0-5	arginine vasopressin receptor 2	Rattus norvegicus	58-81
10614652-7	2000	This study demonstrates that vasopressin V2 receptor binding capacity is down-regulated during renal escape from vasopressin-induced antidiuresis and suggests that both vasopressin-dependent mechanisms as well as vasopressin-independent mechanisms associated with water loading are involved in this receptor down-regulation.	Water	264-269	arginine vasopressin receptor 2	Rattus norvegicus	29-52
10614652-5	2000	This receptor down-regulation began by day 2 of water loading, which correlated with the initiation of renal vasopressin escape; by day 3 of water loading, vasopressin V2 receptor expression fell to 43% of DDAVP-treated levels.	Water	48-53	arginine vasopressin	Rattus norvegicus	109-120
10614652-7	2000	This study demonstrates that vasopressin V2 receptor binding capacity is down-regulated during renal escape from vasopressin-induced antidiuresis and suggests that both vasopressin-dependent mechanisms as well as vasopressin-independent mechanisms associated with water loading are involved in this receptor down-regulation.	Water	264-269	arginine vasopressin	Rattus norvegicus	29-40
10614652-7	2000	This study demonstrates that vasopressin V2 receptor binding capacity is down-regulated during renal escape from vasopressin-induced antidiuresis and suggests that both vasopressin-dependent mechanisms as well as vasopressin-independent mechanisms associated with water loading are involved in this receptor down-regulation.	Water	264-269	arginine vasopressin	Rattus norvegicus	113-124
10614652-7	2000	This study demonstrates that vasopressin V2 receptor binding capacity is down-regulated during renal escape from vasopressin-induced antidiuresis and suggests that both vasopressin-dependent mechanisms as well as vasopressin-independent mechanisms associated with water loading are involved in this receptor down-regulation.	Water	264-269	arginine vasopressin	Rattus norvegicus	113-124
10552271-11	2000	Ad libitum water consumption was higher in HT [HT: GP vs EA, 18.9 (SEM 2.9) vs 13.5 (SEM 1.7) ml x kg(-1) x h(-1); MT: GP vs EA, 12.7 (SEM 3.7) vs 8.5 (SEM 1.5) ml x kg(-1) x h(-1); main effect, group, n.s.	Water	11-16	semaphorin 3G	Homo sapiens	67-72
10938796-12	2000	The aquaporin encoded by AtPIP1 is known to have its water permeation blocked by Hg binding.	Water	53-58	plasma membrane intrinsic protein 1A	Arabidopsis thaliana	25-31
10644880-1	2000	BACKGROUND: Stimulation of arginine vasopressin results in an immediate redistribution of water channels (aquaporin 2; AQP2) in the apical membrane of the collecting ducts, leading to water reabsorption.	Water	90-95	arginine vasopressin	Rattus norvegicus	36-47
10659969-5	2000	The insulin clamp treatments increased milk protein yield by 15 and 25% during abomasal infusion of water or casein plus branched-chain amino acids, respectively.	Water	100-105	insulin	Homo sapiens	4-11
11931114-5	2000	Oxidation of [RuII(Por)-(NH2tBu)2] by bromine in dichloromethane in the presence of tert-butylamine and traces of water produced oxo(imido)ruthenium(VI) porphyrins, [RuVI-O(Por)(NtBu)] (Por=TPP, 3,4,5-MeO-TPP, TTP, 4-Cl-TPP, 3,5-Cl-TPP).	Water	114-119	cytochrome p450 oxidoreductase	Homo sapiens	19-22
11931114-5	2000	Oxidation of [RuII(Por)-(NH2tBu)2] by bromine in dichloromethane in the presence of tert-butylamine and traces of water produced oxo(imido)ruthenium(VI) porphyrins, [RuVI-O(Por)(NtBu)] (Por=TPP, 3,4,5-MeO-TPP, TTP, 4-Cl-TPP, 3,5-Cl-TPP).	Water	114-119	cytochrome p450 oxidoreductase	Homo sapiens	173-176
11931114-5	2000	Oxidation of [RuII(Por)-(NH2tBu)2] by bromine in dichloromethane in the presence of tert-butylamine and traces of water produced oxo(imido)ruthenium(VI) porphyrins, [RuVI-O(Por)(NtBu)] (Por=TPP, 3,4,5-MeO-TPP, TTP, 4-Cl-TPP, 3,5-Cl-TPP).	Water	114-119	cytochrome p450 oxidoreductase	Homo sapiens	173-176
10919092-2	2000	Injection of dopamine and angiotensin-II into this nucleus has been documented to affect water and food intake in rats.	Water	89-94	angiotensinogen	Rattus norvegicus	26-40
10619865-1	2000	The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia, AQP4 in airway epithelia, and AQP5 at the apical plasma membrane in type I cells of alveolar epithelia.	Water	29-34	aquaporin 1 (Colton blood group)	Homo sapiens	56-60
10995066-7	2000	The first one is important for obtaining bioavailable thrombin inhibitors, devoid of the high basicity of the commonly used arginine/amidine-based inhibitors, whereas the second one may lead to improved water solubility of such compounds.	Water	203-208	coagulation factor II, thrombin	Homo sapiens	54-62
10719760-2	2000	Water deprivation caused comparable dehydration, increased plasma VP (pVP), and decreased posterior pituitary (PP) VP content in 4-, 15-, and 28-month-old rats.	Water	0-5	arginine vasopressin	Rattus norvegicus	66-68
10719760-4	2000	The elevated pVP in the water-deprived aged rats indicates that even without an increase in VP mRNA content, PP VP storage was adequate to maintain elevated pVP.	Water	24-29	arginine vasopressin	Rattus norvegicus	14-16
10667860-7	2000	However, Lyso reactivity reached a maximum when the concentration of micelles was approximately 1 x 10(-5), the same as the protein concentration In AOT reverse micelles, the quenching rate constants decreased &gt; 75% with respect to water.	Water	235-240	lysozyme	Homo sapiens	9-13
10728802-10	2000	Two families of drugs, the V2 vasopressin receptor antagonists and the kappa-opioid agonists, have been shown to improve free water clearance and correct dilutional hyponatremia in human and experimental cirrhosis with ascites.	Water	126-131	arginine vasopressin	Homo sapiens	30-41
10720884-6	2000	Administration of superoxide dismutase (SOD), which dismutates.O(-)(2) to H(2)O(2), and of catalase which reacts with H(2)O(2) to form H(2)O and molecular oxygen failed to inhibit the increased extravasation of the macromolecular tracer when administered separately.	Water	118-123	catalase	Rattus norvegicus	91-99
11043826-5	2000	A part of animals drank melatonin in a concentration 100 microg/ml of tap water, continuously from the beginning of irradiation and 26 weeks after its end.	Water	74-79	nuclear RNA export factor 1	Rattus norvegicus	70-73
10790965-0	2000	[Effects of angiotensin-converting enzyme (ACE) inhibitors on water-salt homeostasis in hypertensive patients living in Far North].	Water	62-67	angiotensin I converting enzyme	Homo sapiens	12-41
10790965-0	2000	[Effects of angiotensin-converting enzyme (ACE) inhibitors on water-salt homeostasis in hypertensive patients living in Far North].	Water	62-67	angiotensin I converting enzyme	Homo sapiens	43-46
10790965-1	2000	The aim of the study was evaluation of ACE inhibitors (captopril and ramipril) effect on water-salt homeostasis in the treatment of patients with arterial hypertension (AH) living in the Far North of Russia.	Water	89-94	angiotensin I converting enzyme	Homo sapiens	39-42
10638636-7	2000	(-)-Bremazocine was slightly more potent in suppressing vasopressin in 24-h water-deprived males than females.	Water	76-81	arginine vasopressin	Rattus norvegicus	56-67
10682705-1	2000	Increasing evidence suggests that Angiotensin II, classically known from its many effects regulating salt and water homeostasis, is also involved in brain development and cognitive functions through activation of AT1 Angiotensin II receptors.	Water	110-115	angiotensinogen	Homo sapiens	34-48
10682705-1	2000	Increasing evidence suggests that Angiotensin II, classically known from its many effects regulating salt and water homeostasis, is also involved in brain development and cognitive functions through activation of AT1 Angiotensin II receptors.	Water	110-115	angiotensinogen	Homo sapiens	217-231
12110907-5	2000	betaB2-crystallin comprised about 30% of the total bacterial proteins and it is water-soluble.	Water	80-85	crystallin, beta B2	Rattus norvegicus	0-17
11227384-7	2000	These peptides are slowly metabolised and their plasma concentration is higher than ANF suggesting their important role in water-electrolyte homeostasis and regulation of vascular tone.	Water	123-128	natriuretic peptide A	Homo sapiens	84-87
11195196-4	2000	The vasopressin plays a leading role in pathogenesis of disturbed water metabolism in the liver cirrhosis.	Water	66-71	arginine vasopressin	Homo sapiens	4-15
11195196-7	2000	Using in practice vasopressin-type 2 (V-2) receptor antagonists gives hopeful results in medical treatment of water-electrolyte disturbances in patients with advanced liver cirrhosis.	Water	110-115	arginine vasopressin	Homo sapiens	18-29
10626806-6	1999	Moreover, the combination of TRAIL and CPT-11, a water-soluble analogue of camptothecin, greatly enhanced the antitumor activity of TRAIL in vivo.	Water	49-54	TNF superfamily member 10	Homo sapiens	29-34
10600179-7	1999	These results indicate that the inhibition of PKCalpha by resveratrol can be mediated, at least partially, by membrane effects exerted near the lipid-water interface.	Water	150-155	protein kinase C alpha	Homo sapiens	46-54
10626806-6	1999	Moreover, the combination of TRAIL and CPT-11, a water-soluble analogue of camptothecin, greatly enhanced the antitumor activity of TRAIL in vivo.	Water	49-54	TNF superfamily member 10	Homo sapiens	132-137
10619595-2	1999	Because Ang II affects blood pressure control, sodium and water homeostasis, and cardiovascular function and structure, a great deal of research effort has been directed toward blocking the RAS.	Water	58-63	angiotensinogen	Homo sapiens	8-14
10585414-1	1999	Lactoperoxidase (LPO) reacts with H(2)O(2) to sequentially give two Compound I intermediates: the first with a ferryl (Fe(IV)=O) species and a porphyrin radical cation, and the second with the same ferryl species and a presumed protein radical.	Water	34-39	lactoperoxidase	Homo sapiens	0-15
10585414-1	1999	Lactoperoxidase (LPO) reacts with H(2)O(2) to sequentially give two Compound I intermediates: the first with a ferryl (Fe(IV)=O) species and a porphyrin radical cation, and the second with the same ferryl species and a presumed protein radical.	Water	34-39	lactoperoxidase	Homo sapiens	17-20
10587459-1	1999	Aquaporin-2 (AQP2), a vasopressin-regulated water channel, plays a major role in urinary concentration.	Water	44-49	aquaporin 2 S homeolog	Xenopus laevis	13-17
10587459-3	1999	Despite the similarities of these proteins, however, the water channel activity of AQP2 is much higher than that of MIP.	Water	57-62	aquaporin 2 S homeolog	Xenopus laevis	83-87
10587459-5	1999	When expressed in Xenopus oocytes, the osmotic water permeability (P(f)) of MIP and AQP2 was 48 and 245 x 10(-)(4) cm/s, respectively.	Water	47-52	aquaporin 2 S homeolog	Xenopus laevis	84-88
10497287-2	1999	The water-soluble amphiphilic phospholipid polymer, poly[2-methacryloyloxyethyl phosphorylcholine (MPC)-co-styrene (St)] was synthesized, and its stabilizing functions for the antibody were compared with conventional stabilizers of the antibody conjugated with enzyme (enzyme-antibody conjugate), such as bovine serum albumin (BSA) and casein.	Water	4-9	albumin	Homo sapiens	312-331
10619573-4	1999	Angiotensin II also alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.	Water	44-49	angiotensinogen	Homo sapiens	0-14
10583370-1	1999	A water-soluble iron complex with N-dithiocarboxysarcosine (Fe-DTCS) has been developed as an ESR spin-trapping agent for NO and successfully applied to ESR imaging of endogenous NO production in mice.	Water	2-7	esterase 5 regulator	Mus musculus	94-97
10547529-5	1999	In this study, we use molecular dynamics simulations of 2-Zn insulin in water solvent to explore the further effect of vicinal polar or charged groups on hydrophobic hydration at a biomolecular surface.	Water	72-77	insulin	Homo sapiens	61-68
10547529-6	1999	In contrast to the case for solvent more isolated from such polar solute influences, the binding energies of the water that is proximal to the hydrophobic dimeric interface of insulin and vicinal to polar and charged groups are comparable to the bulk solvent value, a result of compensating interaction primarily with the solute counterions.	Water	113-118	insulin	Homo sapiens	176-183
10590225-5	1999	The mean DNA damage, expressed as the ratio of tail intensity (fluorescence in the tail) to total intensity of the comet after incubation with faecal water from volunteers consuming diet 1 was about twice as high as for diet 2.	Water	150-155	MAM and LDL receptor class A domain containing 1	Homo sapiens	182-188
10583370-1	1999	A water-soluble iron complex with N-dithiocarboxysarcosine (Fe-DTCS) has been developed as an ESR spin-trapping agent for NO and successfully applied to ESR imaging of endogenous NO production in mice.	Water	2-7	esterase 5 regulator	Mus musculus	153-156
10600556-1	1999	Aquaporin-1 is a water channel found in mammalian red blood cells that is responsible for high water permeability of its membrane.	Water	17-22	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
10701943-3	1999	The binding of phenoxazine derivatives to bovine serum albumin is correlated with their octanol-water partition coefficient, log10P.	Water	96-101	albumin	Homo sapiens	49-62
10578016-5	1999	The permeability and binding selectivity patterns of CFTR differed only by a multiplicative constant from that of the PVC-TDMAC membrane; and a continuum electrostatic model suggested that both patterns could be understood in terms of the differences in the relative stabilization of anions by water and the polarizable interior of the channel or synthetic membrane.	Water	294-299	CF transmembrane conductance regulator	Homo sapiens	53-57
10600556-1	1999	Aquaporin-1 is a water channel found in mammalian red blood cells that is responsible for high water permeability of its membrane.	Water	95-100	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
10600556-6	1999	A pore found close to the center of the aquaporin-1 monomer is suggested to be the course of water flow with implications for the water selectivity.	Water	93-98	aquaporin 1 (Colton blood group)	Homo sapiens	40-51
10600556-6	1999	A pore found close to the center of the aquaporin-1 monomer is suggested to be the course of water flow with implications for the water selectivity.	Water	130-135	aquaporin 1 (Colton blood group)	Homo sapiens	40-51
10596388-4	1999	The activity of CRH neurons was assessed by changes in CRH mRNA levels in response to both stimulatory and inhibitory conditions induced by immobilization and water deprivation, respectively.	Water	159-164	corticotropin releasing hormone	Rattus norvegicus	16-19
10633465-4	1999	The CaR also affects the renal handling of sodium, magnesium and water.	Water	65-70	calcium sensing receptor	Homo sapiens	4-7
10657732-4	1999	Salt-loading (2% NaCl as drinking water), an animal model which increases the expression and secretion of hormones from hypothalamic magnocellular neurons, resulted in significantly increased mRNA levels for VAMP-2 (36%, 28%), munc-18 (74%, 68%) and SNAP-25a (59%, 77%) in the PVN and SON, respectively.	Water	34-39	vesicle associated membrane protein 2	Homo sapiens	208-214
10596388-4	1999	The activity of CRH neurons was assessed by changes in CRH mRNA levels in response to both stimulatory and inhibitory conditions induced by immobilization and water deprivation, respectively.	Water	159-164	corticotropin releasing hormone	Rattus norvegicus	55-58
11970595-4	1999	The dramatic change in water"s dynamic and structural properties as a function of pressure allows us to confirm the predictions of MCT over a much broader range of the von Schweidler exponent values than has been studied for simple atomic liquids.	Water	23-28	solute carrier family 16 member 1	Homo sapiens	131-134
10705716-5	1999	The superoxide dismutase enzyme (SOD) catalyzes dismutation of the superoxide radical into hydrogen peroxide and oxygen hydrogen peroxide is in turn reduced to water and oxygen by peroxidase glutathione and catalase enzymes.	Water	160-165	superoxide dismutase 1	Homo sapiens	4-31
10705716-5	1999	The superoxide dismutase enzyme (SOD) catalyzes dismutation of the superoxide radical into hydrogen peroxide and oxygen hydrogen peroxide is in turn reduced to water and oxygen by peroxidase glutathione and catalase enzymes.	Water	160-165	superoxide dismutase 1	Homo sapiens	33-36
10705716-5	1999	The superoxide dismutase enzyme (SOD) catalyzes dismutation of the superoxide radical into hydrogen peroxide and oxygen hydrogen peroxide is in turn reduced to water and oxygen by peroxidase glutathione and catalase enzymes.	Water	160-165	catalase	Homo sapiens	207-215
10594930-1	1999	Superoxide dismutase (SOD) converts superoxide radical to H(2)O(2), which is in turn broken down to water and oxygen by catalase.	Water	100-105	catalase	Homo sapiens	120-128
10639821-10	1999	Congenital NDI with an autosomal recessive inheritance has mutations of Aquaporin-2 gene, a vasopressin-sensitive water channel in the renal inner medullary collecting duct (IMCD).	Water	114-119	arginine vasopressin	Homo sapiens	92-103
10611403-1	1999	To model the molten globule structure of alpha-lactalbumin, molecular dynamics (MD) simulations were carried out for the protein in explicit water at high temperature.	Water	141-146	lactalbumin alpha	Homo sapiens	41-58
10567349-13	1999	An increase in the capacity to remove H(2)O(2) was observed when TGF-beta was removed by neutralizing antibodies.	Water	38-43	transforming growth factor, beta 1	Rattus norvegicus	65-73
10506412-5	1999	Recombinant apolipoprotein A-1, the Milano variant, was extracted from E. coli fermentation solution in a primary Breox-starch phase system followed by thermal separation of the Breox phase where the target protein was recovered in the water phase.	Water	236-241	apolipoprotein A1	Homo sapiens	12-30
10563795-1	1999	Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed.	Water	68-73	cytochrome c, somatic	Homo sapiens	0-12
10579822-2	1999	We have investigated the conformational behavior of PmB and PmE in water solution, free and bound to LPS, by homonuclear NMR and molecular modeling methods.	Water	67-72	cystatin B	Homo sapiens	60-63
10564779-1	1999	The fragmentation of human Cu,Zn-superoxide dismutase (SOD) was observed during incubation with H(2)O(2).	Water	96-101	superoxide dismutase 1	Homo sapiens	27-53
10564779-1	1999	The fragmentation of human Cu,Zn-superoxide dismutase (SOD) was observed during incubation with H(2)O(2).	Water	96-101	superoxide dismutase 1	Homo sapiens	55-58
10556530-1	1999	The classical short-term effect (within minutes) of arginine vasopressin (AVP) consists in increasing sodium, chloride and water transport in kidney cells.	Water	123-128	arginine vasopressin	Rattus norvegicus	61-72
10556530-1	1999	The classical short-term effect (within minutes) of arginine vasopressin (AVP) consists in increasing sodium, chloride and water transport in kidney cells.	Water	123-128	arginine vasopressin	Rattus norvegicus	74-77
10564231-2	1999	We recently identified a broad selective-neutral solute channel, AQP9, from rat liver that allows the passage of a wide variety of water and neutral solutes (H. Tsukaguchi, C. Shayakul, U. V. Berger, B. Mackenzie, S. Devidas, W. B. Guggino, A. N. van Hoek, and M. A. Hediger.	Water	131-136	aquaporin 9	Rattus norvegicus	65-69
10556905-1	1999	The membrane-permeating indicator DAF-FM DA is transformed by intracellular esterases into the highly water-soluble dye DAF-FM, which traps NO produced by NO synthase (NOS) to yield a highly fluorescent triazole compound in cells (see schematic diagram).	Water	102-107	nitric oxide synthase 2	Homo sapiens	155-166
10564231-6	1999	A human homolog (hAQP9) with 76% amino acid sequence identity to rat AQP9 (rAQP9) was described, but its permeability was found to be restricted to water and urea (K. Ishibashi, M. Kuwahara, Y. Gu, Y. Tanaka, F. Marumo, and S. Sasaki.	Water	148-153	aquaporin 9	Homo sapiens	17-22
10564231-6	1999	A human homolog (hAQP9) with 76% amino acid sequence identity to rat AQP9 (rAQP9) was described, but its permeability was found to be restricted to water and urea (K. Ishibashi, M. Kuwahara, Y. Gu, Y. Tanaka, F. Marumo, and S. Sasaki.	Water	148-153	aquaporin 9	Rattus norvegicus	18-22
10690135-2	1999	Aquaporin-2 (AQP2) is an arginine vasopressin (AVP)-regulated water channel protein localized to the apical region of renal collecting duct cells and is involved in the regulation of water permeability.	Water	62-67	arginine vasopressin	Homo sapiens	47-50
15374053-3	1999	Under stress (emotional-painful stress, water deprivation) the potential capabilities of the VP-ergic system decreased with age.	Water	40-45	arginine vasopressin	Homo sapiens	93-95
10559843-2	1999	Water intake increased in all animals after angiotensin II (ANG II) injection into the LV, with values of 14.2 +/- 1.4 ml/h.	Water	0-5	angiotensinogen	Rattus norvegicus	44-58
10559843-2	1999	Water intake increased in all animals after angiotensin II (ANG II) injection into the LV, with values of 14.2 +/- 1.4 ml/h.	Water	0-5	angiotensinogen	Rattus norvegicus	60-66
10650912-0	1999	Modulation of tumor necrosis factor alpha expression in mouse brain after exposure to aluminum in drinking water.	Water	107-112	tumor necrosis factor	Mus musculus	14-41
10690135-2	1999	Aquaporin-2 (AQP2) is an arginine vasopressin (AVP)-regulated water channel protein localized to the apical region of renal collecting duct cells and is involved in the regulation of water permeability.	Water	183-188	arginine vasopressin	Homo sapiens	47-50
10537135-3	1999	iv infusion of a nondipsogenic dose of angiotensin II (0.5 microg/h), combined with relaxin (40 microg/kg x h), almost tripled the relaxin-induced water intake.	Water	147-152	angiotensinogen	Rattus norvegicus	39-53
10889318-7	1999	The first one is important for obtaining bioavailable thrombin inhibitors, devoid of the high basicity of the commonly used arginine/amidine-based inhibitors, whereas the second one may lead to improved water solubility of such compounds due to facilitated salt formation as well as increased stability at hydrolysis (in vivo).	Water	203-208	coagulation factor II, thrombin	Homo sapiens	54-62
10541904-3	1999	The purpose of this study was to investigate the role of B7-1 and B7-2 in the EAU model in mice.	Water	78-81	CD80 antigen	Mus musculus	57-70
12552705-1	1999	A method to decrease the detection limit of trace benzene in CS2 extract from coastal water by gas chromatography has been studied.	Water	86-91	chorionic somatomammotropin hormone 2	Homo sapiens	61-64
10587314-7	1999	cyclo(-D-Asp1-Asp2-Gly3-Ahd4-Ahd5-Gly6-) (C3) clearly exhibits two different conformations with a shifted beta,beta-turn motif in CDCI3 and SDS/H2O solutions.	Water	144-147	beta-secretase 1	Homo sapiens	14-18
10549650-8	1999	The propensity of B10.RIII mice to mount a more polarized Th1 response to IRBP than other strains may contribute to their ability to develop EAU without pertussis adjuvant.	Water	141-144	negative elongation factor complex member C/D, Th1l	Mus musculus	58-61
12552705-5	1999	The experiment showed that the trace water in the organic phase and the too small purge flow of the direct injection port could cause serious tailing of CS2 peak.	Water	37-42	chorionic somatomammotropin hormone 2	Homo sapiens	153-156
10512702-0	1999	Dissecting the stability of a beta-hairpin peptide that folds in water: NMR and molecular dynamics analysis of the beta-turn and beta-strand contributions to folding.	Water	65-70	amyloid beta precursor protein	Homo sapiens	28-34
10521352-1	1999	The cystic fibrosis gene encodes a chloride channel, CFTR (cystic fibrosis transmembrane conductance regulator), that regulates salt and water transport across epithelial tissues.	Water	137-142	CF transmembrane conductance regulator	Homo sapiens	53-57
10521352-1	1999	The cystic fibrosis gene encodes a chloride channel, CFTR (cystic fibrosis transmembrane conductance regulator), that regulates salt and water transport across epithelial tissues.	Water	137-142	CF transmembrane conductance regulator	Homo sapiens	59-110
10505693-1	1999	Aquaporin-2 (AQP-2), a water channel located on the apical membrane of collecting duct cells, regulates water reabsorption under the control of vasopressin (AVP).	Water	104-109	arginine vasopressin	Homo sapiens	144-155
10510262-7	1999	When the effect of lead administration on angiotensin II-induced water and salt intake was studied, normohydrated animals received third ventricle injections of angiotensin II (9.6 nmol/rat) after pretreatment with 3.0 nmol/rat of PbAc (experimental group, N = 10) or NaAc (controls, N = 8).	Water	65-70	angiotensinogen	Rattus norvegicus	42-56
10520782-0	1999	Improvement of myocardial blood flow to ischemic regions by angiotensin-converting enzyme inhibition with quinaprilat IV: a study using [15O] water dobutamine stress positron emission tomography.	Water	142-147	angiotensin I converting enzyme	Homo sapiens	60-89
10544890-7	1999	In combination with a simple solid-phase extraction step (200 ml of water on a 500 mg C18-bonded silica) the analytical procedure provides a high sample throughput.	Water	68-73	Bardet-Biedl syndrome 9	Homo sapiens	86-89
10591010-2	1999	Control rats receiving tap water did not show a significant change in blood pressure or abnormalities in the kidney.	Water	27-32	nuclear RNA export factor 1	Rattus norvegicus	23-26
10497050-2	1999	The use of this water flipback technique is shown to significantly enhance signal in 3D 15N-edited ROESY in a 20 kDa complex of the vnd/NK-2 homeodomain bound to DNA.	Water	16-21	NK2 homeobox 1	Homo sapiens	136-140
10547152-1	1999	CNI-1493, a newly developed, water-soluble tetravalent guanylhydrazone, is a powerful inhibitor of tumor necrosis factor (TNF) and interleukin-1 (IL-1) synthesis.	Water	29-34	tumor necrosis factor	Rattus norvegicus	122-125
10563586-0	1999	Comparison of the structures of beta amyloid peptide (25-35) and substance P in trifluoroethanol/water solution.	Water	97-102	amyloid beta precursor protein	Homo sapiens	32-52
10563586-0	1999	Comparison of the structures of beta amyloid peptide (25-35) and substance P in trifluoroethanol/water solution.	Water	97-102	tachykinin precursor 1	Homo sapiens	65-76
10451552-0	1999	Explicit and implicit water simulations of a beta-hairpin peptide.	Water	22-27	amyloid beta precursor protein	Homo sapiens	43-49
10451552-1	1999	The conformational properties of a beta-hairpin peptide (YITNSDGTWT) were studied by using both explicit and implicit water simulations.	Water	118-123	amyloid beta precursor protein	Homo sapiens	33-39
10479713-7	1999	Fos-like immunoreactivity (FLI) was significantly higher in the superficial laminae of dorsomedial and ventrolateral Vc in animals treated with carbonated water versus controls.	Water	155-160	FLII actin remodeling protein	Homo sapiens	0-25
10534423-13	1999	Increased expression of NHE-3 secondary to SBR and/or EGF treatment with loss of this increase following salivarectomy implies a common mechanism to enhance enterocyte proliferation and luminal absorption of NaCl and water.	Water	217-222	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	24-29
10522494-7	1999	The total number and area of GST-P positive foci in DEN-treated rats exposed to the full seven-chemical mixture was increased as compared with the DEN-water controls, but this was statistically significant only for total focus area in the 1x dose group.	Water	151-156	glutathione S-transferase pi 1	Rattus norvegicus	29-34
10526122-4	1999	The efficacy of orexin-A was almost comparable with that of angiotensin II, and the effect lasted more than 3 h. Prepro-orexin mRNA level was up-regulated when rats were deprived of water.	Water	182-187	hypocretin neuropeptide precursor	Rattus norvegicus	16-24
10526122-4	1999	The efficacy of orexin-A was almost comparable with that of angiotensin II, and the effect lasted more than 3 h. Prepro-orexin mRNA level was up-regulated when rats were deprived of water.	Water	182-187	hypocretin neuropeptide precursor	Rattus norvegicus	16-22
10469539-4	1999	Based on EXAFS results and bond valence analysis, plausible surface complexation reactions for Co(II) sorption on these two surfaces can be written as represent surface water molecules, hydroxyl groups, and oxygens bonded to one, two, and three Al cations, respectively.	Water	169-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
10479713-7	1999	Fos-like immunoreactivity (FLI) was significantly higher in the superficial laminae of dorsomedial and ventrolateral Vc in animals treated with carbonated water versus controls.	Water	155-160	FLII actin remodeling protein	Homo sapiens	27-30
10628383-5	1999	In addition, the water-soluble derivatives were able to induce apoptosis in the examined DLD-1 and KM20L2 colon carcinoma cell lines in contrast to the parent compound 7 beta HC, as shown by DNA fragmentation, by the cleavage of DNA repair enzyme poly(ADP) ribose polymerase (PARP), and by the proteolytic cleavage of caspase-3 (CPP32).	Water	17-22	poly(ADP-ribose) polymerase 1	Homo sapiens	276-280
10473575-6	1999	In view of the comparable protection by catalase overexpressed in the cytosol versus the mitochondria, catalase produced in both cellular compartments might act as a sink to decompose H(2)O(2) and move diffusable H(2)O(2) down its concentration gradient.	Water	184-189	catalase	Homo sapiens	103-111
10473575-6	1999	In view of the comparable protection by catalase overexpressed in the cytosol versus the mitochondria, catalase produced in both cellular compartments might act as a sink to decompose H(2)O(2) and move diffusable H(2)O(2) down its concentration gradient.	Water	213-218	catalase	Homo sapiens	103-111
10485245-10	1999	CONCLUSION: RARE-MR-urography is a noninvasive method which demonstrates the pathognomonic water-filled cystic structures throughout the kindeys in ARPKD.	Water	91-96	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Homo sapiens	148-153
10544378-1	1999	BACKGROUND: Adult growth hormone (GH) deficiency is associated with changes in body composition, with lower total body water (TBW) and fat free mass (FFM) and higher fat mass (FM).	Water	119-124	growth hormone 1	Homo sapiens	18-32
10518953-6	1999	Three-dimensional reconstruction of negatively stained lattices revealed the p42(1)2 packing arrangement that is also observed with the human erythrocyte water channel (AQP1).	Water	154-159	aquaporin 1 (Colton blood group)	Homo sapiens	169-173
10628383-5	1999	In addition, the water-soluble derivatives were able to induce apoptosis in the examined DLD-1 and KM20L2 colon carcinoma cell lines in contrast to the parent compound 7 beta HC, as shown by DNA fragmentation, by the cleavage of DNA repair enzyme poly(ADP) ribose polymerase (PARP), and by the proteolytic cleavage of caspase-3 (CPP32).	Water	17-22	caspase 3	Homo sapiens	318-327
10628383-5	1999	In addition, the water-soluble derivatives were able to induce apoptosis in the examined DLD-1 and KM20L2 colon carcinoma cell lines in contrast to the parent compound 7 beta HC, as shown by DNA fragmentation, by the cleavage of DNA repair enzyme poly(ADP) ribose polymerase (PARP), and by the proteolytic cleavage of caspase-3 (CPP32).	Water	17-22	caspase 3	Homo sapiens	329-334
10499190-12	1999	These results suggest that vasopressin elevation in DM contributes to increase urinary concentrating activity and thus to limit water requirements induced by the metabolic derangements of DM.	Water	128-133	arginine vasopressin	Rattus norvegicus	27-38
10465766-8	1999	Our data indicate that 1) electrostatic interaction is the main driving force for binding of multivalent cations to DNA; 2) DNA condensation is dependent on the structure of the condensing agent; and 3) the hydration pattern or polarization of water molecules on the surface of condensing agents plays an important role in DNA condensation and chiral recognition.	Water	244-249	DNA replication helicase/nuclease 2	Homo sapiens	116-122
10485491-5	1999	By delivering the VEGF gene within the self-contained tetracycline-regulated retroviral vector (Retro-Tet) into hepatocellular carcinoma (HCC) cells, we manipulated VEGF expression by providing tetracycline in the drinking water to assess the tumor kinetics mediated exclusively by VEGF.	Water	223-228	vascular endothelial growth factor A	Homo sapiens	18-22
10489388-1	1999	The renin-angiotensin-aldosterone system plays an important role in blood pressure regulation by influencing salt-water homeostasis and vascular tone.	Water	114-119	renin	Homo sapiens	4-9
10499781-4	1999	In fact it improves by about 60% the sensitivity of the FOX1 method for water soluble peroxides, and by 7-8 times that of the FOX2 method for lipid soluble peroxides.	Water	72-77	RNA binding fox-1 homolog 1	Homo sapiens	56-60
10559675-0	1999	Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes.	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
10498302-8	1999	In vessels perfused for 2 hours with TNF at 10 ng/mL, Lp was 0.96+/-0.33 x 10(-7) cm/(s x cm H2O) (n = 4, p = 0.66).	Water	93-96	tumor necrosis factor	Homo sapiens	37-40
10477136-1	1999	Four prostaglandin E2 receptor subtypes designated EP1, EP2, EP3, and EP4 have been shown to mediate a variety of effects of prostaglandin E2 (PGE2) on glomerular hemodynamics, tubular salt and water reabsorption, and on blood vessels in the human kidney.	Water	194-199	prostaglandin E receptor 3	Homo sapiens	61-64
10559675-6	1999	Finally, by measuring the rate of change in cell size induced by changes in external osmolarity and demonstrating that water transport can be inhibited with mercuric chloride, we show that AQP-1 is responsible for water transport across human VSMC membranes.	Water	119-124	aquaporin 1 (Colton blood group)	Homo sapiens	189-194
10559675-6	1999	Finally, by measuring the rate of change in cell size induced by changes in external osmolarity and demonstrating that water transport can be inhibited with mercuric chloride, we show that AQP-1 is responsible for water transport across human VSMC membranes.	Water	214-219	aquaporin 1 (Colton blood group)	Homo sapiens	189-194
10452808-5	1999	The MPO-specific reaction is believed to proceed in two steps: (i) the enzymatic generation of hypobromous acid (HOBr) from KBr and H(2)O(2) at pH 5 and (ii) the spontaneous reaction of HOBr and H(2)O(2) with luminol to give a Br-CL signal.	Water	132-137	myeloperoxidase	Homo sapiens	4-7
10461037-1	1999	Parathyroid hormone (PTH) has multiple effects on water and electrolyte transport along the nephron.	Water	50-55	parathyroid hormone	Rattus norvegicus	0-19
10461037-1	1999	Parathyroid hormone (PTH) has multiple effects on water and electrolyte transport along the nephron.	Water	50-55	parathyroid hormone	Rattus norvegicus	21-24
10449741-3	1999	Surprisingly, our computational analysis of the binding of a buried water molecule to bovine pancreatic trypsin inhibitor shows that the protein actually becomes more flexible, as revealed by an increase in the vibrational entropy.	Water	68-73	trophoblast Kunitz domain protein 1	Bos taurus	104-121
10449741-4	1999	We find that this effect must be common in proteins, because the large entropic cost of immobilizing a single water molecule [-TDeltaS = 20.6 kcal/mol (1 kcal = 4.18 kJ) for the lost translational and rotational degrees of freedom] can only be partly compensated by water-protein interactions, even when they are nearly perfect, as in the case of bovine pancreatic trypsin inhibitor (DeltaE = -19.8 kcal/mol), leaving no room for a further decrease in entropy from protein tightening.	Water	110-115	trophoblast Kunitz domain protein 1	Bos taurus	365-382
10449741-4	1999	We find that this effect must be common in proteins, because the large entropic cost of immobilizing a single water molecule [-TDeltaS = 20.6 kcal/mol (1 kcal = 4.18 kJ) for the lost translational and rotational degrees of freedom] can only be partly compensated by water-protein interactions, even when they are nearly perfect, as in the case of bovine pancreatic trypsin inhibitor (DeltaE = -19.8 kcal/mol), leaving no room for a further decrease in entropy from protein tightening.	Water	266-271	trophoblast Kunitz domain protein 1	Bos taurus	365-382
10452808-5	1999	The MPO-specific reaction is believed to proceed in two steps: (i) the enzymatic generation of hypobromous acid (HOBr) from KBr and H(2)O(2) at pH 5 and (ii) the spontaneous reaction of HOBr and H(2)O(2) with luminol to give a Br-CL signal.	Water	195-200	myeloperoxidase	Homo sapiens	4-7
10484175-7	1999	Calculation of the number of water molecules that additionally bind to unfolded RNase A resulted in surprisingly low numbers for both osmolytes.	Water	29-34	ribonuclease pancreatic	Bos taurus	80-87
10446070-3	1999	In this study, we describe the stable overexpression of human catalase in smooth muscle cells and the resistance of these cells to cytotoxicity induced not only by the addition of H(2)O(2) but also by the addition of 13-hydroperoxyoctadecadienoic acid (13-HPODE).	Water	180-185	catalase	Homo sapiens	62-70
10474781-10	1999	The water diuretic effect of BK was abolished in dogs given both NOARG and ibuprofen (12.5 mg/kg bolus injection plus 12.5 mg/kg per h of sustained infusion intravenously), a cyclooxygenase inhibitor.	Water	4-9	kininogen 1	Canis lupus familiaris	29-31
10474781-13	1999	Renal vasodilative and natriuretic responses are mainly linked to NO generation, while both NO and prostaglandin biosynthesis are involved in the BK-induced water diuresis.	Water	157-162	kininogen 1	Canis lupus familiaris	146-148
10468195-2	1999	The role of H2O2 in these rats may be studied modulating the amount or activity of catalase, which breakdowns H2O2 to water and oxygen.	Water	118-123	catalase	Rattus norvegicus	83-91
10643675-5	1999	Removal of IV-VI semiconductor laser structures from the silicon growth substrate by dissolving BaF2 buffer layers with water is also demonstrated.	Water	120-125	BANF family member 2	Homo sapiens	96-100
10774668-4	1999	The investigation indicated that snail distribution and human schistosomiasis prevalence differed significantly between years which had typically high, middle and low typical water levels in the Yangzte.	Water	175-180	snail family transcriptional repressor 1	Homo sapiens	33-38
10443503-5	1999	The aim of this study was to assess the effects of a water-soluble cigarette smoke extract on the production of tumor necrosis factor alpha and nitric oxide from human monocytes in response to staphylococcal toxic shock syndrome toxin 1 or infection of the monocytes with respiratory syncytial virus.	Water	53-58	tumor necrosis factor	Homo sapiens	112-139
28060624-6	1999	A precipitation event collected during westerly winds contained fourfold higher  -PAH and twelvefold higher  -PCB concentrations at the over-water site than at the rural background location, further indicating that the urban plume extends from Baltimore, MD, over the northern Chesapeake Bay over a spatial scale of approximately 30 km.	Water	141-146	pyruvate carboxylase	Homo sapiens	110-113
10460304-2	1999	The congenital disorder is charaterized by a lack or major reduction of catalase, an enzyme that catalyzes the decomposition of hydrogen peroxide to oxygen and water.	Water	160-165	catalase	Homo sapiens	72-80
10439510-1	1999	Hydrogen/deuterium (H/D) exchange chemistry monitored by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is used to study solution phase conformational changes of bradykinin, alpha-melanocyte stimulating hormone, and melittin as water is added to methanol-d4, acetonitrile, and isopropanol-d8 solutions.	Water	270-275	kininogen 1	Homo sapiens	204-214
10440381-1	1999	Cell respiration in mitochondria and some bacteria is catalysed by cytochrome c oxidase, which reduces O2 to water, coupled with translocation of four protons across the mitochondrial or bacterial membrane.	Water	109-114	cytochrome c, somatic	Homo sapiens	67-79
10423240-5	1999	Two-dimensional proton NMR spectroscopy of histatin-5 in a trifluoroethanol/water mixture (a membrane mimetic environment) has been performed and the results analyzed by means of distance geometry and restrained molecular dynamics simulations.	Water	76-81	histatin 3	Homo sapiens	43-53
10423240-7	1999	Comparison of the chemical shifts of the individual amino acids in histatin-5 with those recently reported in other solvents indicates that trifluoroethanol/water has a structuring capability somewhere between water and dimethyl sulfoxide.	Water	157-162	histatin 3	Homo sapiens	67-77
10423240-7	1999	Comparison of the chemical shifts of the individual amino acids in histatin-5 with those recently reported in other solvents indicates that trifluoroethanol/water has a structuring capability somewhere between water and dimethyl sulfoxide.	Water	210-215	histatin 3	Homo sapiens	67-77
10419471-0	1999	Transport of water and glycerol in aquaporin 3 is gated by H(+).	Water	13-18	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	35-46
10419471-2	1999	For AQP3 the osmotic water permeability, L(p), was abolished at acid pH values with a pK of 6.4 and a Hill coefficient of 3.	Water	21-26	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	4-8
10419471-8	1999	For AQP3, water and glycerol interacted by competing for titratable site(s): sigma(Gl) was 0.15 at neutral pH but doubled at pH 6.4.	Water	10-15	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	4-8
10419471-11	1999	We suggest that water and polyols permeate AQP3 by forming successive hydrogen bonds with titratable sites.	Water	16-21	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	43-47
10435757-2	1999	The objective of this study was to examine the effects of a water-soluble cigarette smoke extract (CSE) and/or respiratory syncytial virus (RSV) infection on release from monocytes of the blood from donors of tumour necrosis factor alpha (TNF-alpha) and nitric oxide (NO).	Water	60-65	tumor necrosis factor	Homo sapiens	239-248
10437737-2	1999	Angiotensin II is the principal effector hormone in the RAS, causing vasoconstriction and increased sodium and water retention, leading to increased blood pressure.	Water	111-116	angiotensinogen	Homo sapiens	0-14
10407081-1	1999	The interaction of p-10,12-pentacosadiyne-1-n-phenylamide alpha-D-mannopyranoside (MPDA) with protein concanavalin A (Con A) was studied at the air/water interface.	Water	148-153	S100 calcium binding protein A10	Homo sapiens	19-23
10442213-1	1999	Thiamphenicol glycinate acetylcysteinate (TGA, CAS 20192-91-0) is a water soluble ester of thiamphenicol (TAP) that allows a rapid utilization by the systemic route but also a direct local action when used as aerosol.	Water	68-73	breast cancer anti-estrogen resistance 1	Mus musculus	47-50
10440099-5	1999	Lipid-soluble HMG-CoA reductase inhibitors, lovastatin (10(-6) M) and simvastatin (10(-6) M) partially and significantly inhibited the angiotensin II-induced increases in these parameters, but a water-soluble HMG-CoA reductase inhibitor, pravastatin (10(-6) M) did not.	Water	195-200	angiotensinogen	Rattus norvegicus	135-149
10409270-0	1999	Intracerebroventricular infusion of angiotensin II increases water and ethanol intake in rats.	Water	61-66	angiotensinogen	Rattus norvegicus	36-50
10409270-3	1999	In both groups of rats, infusion of ANG II caused a large increase in water intake (7-fold) and a lesser increase in 10% ethanol intake (2-fold).	Water	70-75	angiotensinogen	Rattus norvegicus	36-42
10446418-8	1999	In order to apply a permanent H(2)O(2)-induced oxidative stress to astroglial cells the generation of H(2)O(2) by the coupled reactions of xanthine oxidase (XO) and superoxide dismutase (SOD) was studied and this system was applied to cultured astroglial cells.	Water	30-35	superoxide dismutase 1	Homo sapiens	165-185
10446418-8	1999	In order to apply a permanent H(2)O(2)-induced oxidative stress to astroglial cells the generation of H(2)O(2) by the coupled reactions of xanthine oxidase (XO) and superoxide dismutase (SOD) was studied and this system was applied to cultured astroglial cells.	Water	30-35	superoxide dismutase 1	Homo sapiens	187-190
10424847-8	1999	ANG II-induced water intake (2.8 +/- 0.9 vs. control = 7.9 +/- 1.7 ml/1 h) and i.c.v.	Water	15-20	angiotensinogen	Rattus norvegicus	0-6
10424847-15	1999	RX 821002 (80 and 160 nmol/1 microl) completely abolished the antidipsogenic action of moxonidine on ANG II-induced water intake.	Water	116-121	angiotensinogen	Rattus norvegicus	101-107
10405197-1	1999	Clinical studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine, and that the excretion increases in response to vasopressin.	Water	79-84	arginine vasopressin	Rattus norvegicus	57-68
10369799-22	1999	Decreased synthesis of ET-1, which normally antagonizes the action of [Arg8]vasopressin, may allow increased water (and sodium) reabsorption at the level of the inner medullary collecting duct.	Water	109-114	endothelin 1	Rattus norvegicus	23-27
10405197-1	1999	Clinical studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine, and that the excretion increases in response to vasopressin.	Water	79-84	arginine vasopressin	Rattus norvegicus	168-179
10381372-6	1999	Ethanol acts as an alternate substrate in place of water for PLD producing phosphatidylethanol (PEt) instead of phosphatidic acid.	Water	51-56	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	61-64
10448972-9	1999	The motifs determined by the NMR analysis of YSFKPMPLaR in H2O and DMSO may represent structural elements important for C5a agonist activity and thus can be used to design the next generation of C5a agonist, partial agonist and antagonist analogs.	Water	59-62	complement C5a receptor 1	Homo sapiens	120-123
10448972-9	1999	The motifs determined by the NMR analysis of YSFKPMPLaR in H2O and DMSO may represent structural elements important for C5a agonist activity and thus can be used to design the next generation of C5a agonist, partial agonist and antagonist analogs.	Water	59-62	complement C5a receptor 1	Homo sapiens	195-198
10509709-4	1999	Two hours post-training there was an increase in the number of Fos-positive stained nuclei in right intermediate medial hyperstriatum ventrale (IMHV) (P &lt; 0.01), left IMHV (P &lt; 0.05), right lobus parolfactorius (LPO) (P &lt; 0.025) and left LPO (P &lt; 0.05) of birds trained on the bitter bead compared with controls that had pecked a water-coated bead.	Water	342-347	Fos proto-oncogene, AP-1 transcription factor subunit	Gallus gallus	63-66
10403428-1	1999	Two-dimensional nuclear magnetic resonance techniques and a combination of distance geometry and molecular dynamics calculations were utilised to determine the three dimensional solution structure of an ET-1 analogue, ET-1[Aib1,3,11,15, Nle7], in a methanol-d3/water co-solvent.	Water	261-266	endothelin 1	Homo sapiens	203-207
10403428-1	1999	Two-dimensional nuclear magnetic resonance techniques and a combination of distance geometry and molecular dynamics calculations were utilised to determine the three dimensional solution structure of an ET-1 analogue, ET-1[Aib1,3,11,15, Nle7], in a methanol-d3/water co-solvent.	Water	261-266	endothelin 1	Homo sapiens	218-222
10373701-8	1999	Passive Na+ and water transport through SGLT1 were blocked by phlorizin with the same sensitivity (inhibitory constant (Ki), 3-5 microM).	Water	16-21	solute carrier family 5 member 1	Homo sapiens	40-45
10373701-12	1999	The activation energies (Ea) for passive Na+ and water transport through SGLT1 were 21 and 5 kcal mol-1, respectively.	Water	49-54	solute carrier family 5 member 1	Homo sapiens	73-78
10373701-15	1999	GAT1 also behaved as an SKF89976A-sensitive water channel.	Water	44-49	solute carrier family 6 member 1	Homo sapiens	0-4
10373701-19	1999	In the case of SGLT1, we suggest that both the water channel and water cotransport could contribute to isotonic fluid transport across the intestinal brush border membrane.	Water	47-52	solute carrier family 5 member 1	Homo sapiens	15-20
10401760-4	1999	Plasma ET-1 levels in Fisher 344 (F344) recipients were 0.8+/-0.1 pg/ml in water-treated rats and 0.2+/-0.2 pg/ml (P&lt;0.01) in PA-treated rats, demonstrating that the PA treatment protocol effectively lowered ET-1 biosynthesis.	Water	75-80	endothelin 1	Rattus norvegicus	7-11
10364230-1	1999	The productive folding pathway of cytochrome c passes through an obligatory HW intermediate in which the heme is coordinated by a solvent water molecule and a native ligand, His-18, prior to the formation of the folded HM state with both the native His-18 and Met-80 heme coordination.	Water	138-143	cytochrome c, somatic	Homo sapiens	34-46
10357775-6	1999	We demonstrated that diluted lipid extracts, from all of the faecal water samples examined, significantly induced AP-1-dependent gene transcription in the colonic cells, and that this effect differed markedly between the extracts.	Water	68-73	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	114-118
10339354-0	1999	Adsorption Dynamics of alpha-Lactalbumin and beta-Lactoglobulin at Air-Water Interfaces.	Water	71-76	lactalbumin alpha	Homo sapiens	23-40
10339354-1	1999	Dynamics of adsorption of 14C radiolabeled beta-lactoglobulin and alpha-lactalbumin at the air-water interface was investigated through the measurement of surface pressure (pi) and surface concentration (Gamma) via a radiotracer technique.	Water	95-100	lactalbumin alpha	Homo sapiens	66-83
10339354-10	1999	The model calculations seem to indicate that alpha-lactalbumin changes its orientation at the air-water interface from side-on to other orientations at higher surface concentrations.	Water	98-103	lactalbumin alpha	Homo sapiens	45-62
16211669-5	1999	Water flow over the dam is analogous to glucose leaving the blood for tissues, which is controlled by insulin.	Water	0-5	insulin	Homo sapiens	102-109
10750587-1	1999	Angiotensin II modulates beat-to-beat cardiac performance as a potent vasocontrictor, inotrope, and regulator of water and electrolyte balance.	Water	113-118	angiotensinogen	Homo sapiens	0-14
10394380-1	1999	VASOPRESSIN: The action of vasopressin (AVP) is not limited to regulating water excretion but also plays an essential role in regulating the corticotropic axis during stress.	Water	74-79	arginine vasopressin	Homo sapiens	0-11
10394380-1	1999	VASOPRESSIN: The action of vasopressin (AVP) is not limited to regulating water excretion but also plays an essential role in regulating the corticotropic axis during stress.	Water	74-79	arginine vasopressin	Homo sapiens	27-38
10357775-7	1999	We confirmed that the faecal water lipid extracts, at the same dilution at which they increased AP-1 activity, significantly induced proliferation in the same cell line.	Water	29-34	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	96-100
10357775-8	1999	These data suggest that lipid components of human faecal water, which is in direct contact with the colon epithelium and may be physiologically more active than the solid phase, can activate AP-1, a transcription factor whose activation has been associated with the promotion of neoplastic transformation.	Water	57-62	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	191-195
11969658-1	1999	We analyze a set of 10 M-step molecular dynamics (MD) data of low-temperature SPC/E model water with a phenomenological analytical model.	Water	90-95	proline rich protein gene cluster	Homo sapiens	78-81
10336607-1	1999	The NMR features of bradykinin were investigated in dimethylsulfoxide containing 1% water.	Water	84-89	kininogen 1	Homo sapiens	20-30
10404348-7	1999	Head-out water immersion produced greater increases in plasma ANP levels in group 2 subjects with longer DTs despite similar degrees of circulatory volume expansion in each group.	Water	9-14	natriuretic peptide A	Homo sapiens	62-65
10388844-3	1999	Analysis of one 1.5 ns molecular dynamics trajectory of apoE-RBD performed in water indicates that the lipid-free domain adopts a structure that exhibits characteristics found in native proteins: it has very stable helices and presents a compact structure.	Water	78-83	apolipoprotein E	Homo sapiens	56-60
10445625-3	1999	In thirty normal subjects, coughing was induced by inhalation of threshold (T) and suprathreshold (1.6 x T) concentrations of ultrasonically nebulized distilled water (fog).	Water	161-166	zinc finger protein, FOG family member 1	Homo sapiens	168-171
10524357-6	1999	The ACE inhibitor fraction was characterized as follows: no significant absorbance, a zwitterion, a water-soluble substance and a positive ninhydrin reaction.	Water	100-105	angiotensin I converting enzyme	Rattus norvegicus	4-7
10382234-5	1999	Real-time recorded [NO] obtained with nasal CNP of -5 cm H2O was again lower than that measured with a noseclip at any expiratory flow rate examined, indicating nasal NO contamination was eliminated irrespective of the flow rate.	Water	57-60	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	44-47
10382234-6	1999	In conclusion, because a nasal CNP of -5 cm H2O was easily tolerated without any discomfort, this technique is a simple, easy and effective technique to eliminate nasal NO which should be widely applicable for the measurement of exhaled [NO].	Water	44-47	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	31-34
10222084-0	1999	Structural Conformation of Bovine Serum Albumin Layers at the Air-Water Interface Studied by Neutron Reflection.	Water	66-71	albumin	Homo sapiens	34-47
10472642-3	1999	The pathophysiologic cascade starts with CFTR dysfunction resulting from mutations of the CFTR gene, and leading to abnormal ion and water transport across airway epithelia.	Water	133-138	CF transmembrane conductance regulator	Homo sapiens	41-45
10472642-3	1999	The pathophysiologic cascade starts with CFTR dysfunction resulting from mutations of the CFTR gene, and leading to abnormal ion and water transport across airway epithelia.	Water	133-138	CF transmembrane conductance regulator	Homo sapiens	90-94
10350584-5	1999	Among the other water samples, 19 in Trad-MCN assay and 17 in Trad-SHM assay show significantly higher genotoxicity than the control.	Water	16-21	RAD51 paralog D	Homo sapiens	37-41
10350584-5	1999	Among the other water samples, 19 in Trad-MCN assay and 17 in Trad-SHM assay show significantly higher genotoxicity than the control.	Water	16-21	RAD51 paralog D	Homo sapiens	62-66
10350584-9	1999	The peak frequencies for the Trad-MCN assays were observed in the water samples obtained from the sites that were near industrial and municipal wastewater that ran into the river as effluent.	Water	66-71	RAD51 paralog D	Homo sapiens	29-33
10350586-7	1999	Both the Trad-MCN and Trad-SHM assays were highly effective for the detection of mutagens in the water samples.	Water	97-102	RAD51 paralog D	Homo sapiens	9-13
10350586-7	1999	Both the Trad-MCN and Trad-SHM assays were highly effective for the detection of mutagens in the water samples.	Water	97-102	RAD51 paralog D	Homo sapiens	22-26
10350602-5	1999	Results of Trad-MCN tests showed a 1.66-4.75 fold increase of MCN frequencies in contaminated soil solution samples and shallow well water samples as compared with the frequencies of the controls.	Water	133-138	RAD51 paralog D	Homo sapiens	11-15
10222084-1	1999	The adsorption of bovine serum albumin (BSA) at the air-water interface has been studied by specular neutron reflection.	Water	56-61	albumin	Homo sapiens	25-38
10342787-5	1999	Inhibition of iNOS by aminoguanidine (0.1% in drinking water) for 9 months, beginning at 13 months of age, reduced blood pressure, improved glomerular filtration rate by 70%, and renal plasma flow by 40%, whereas glomerular sclerosis was considerably reduced.	Water	55-60	nitric oxide synthase 2	Rattus norvegicus	14-18
10399677-3	1999	DuP 753, EXP 3174, saralasin and sarmesin (peptides and non-peptides) dose-dependently inhibited ANGII-induced water intake.	Water	111-116	angiotensinogen	Rattus norvegicus	97-102
10235568-0	1999	Molecular identification and immunolocalization of the water channel protein aquaporin 1 in CBCECs.	Water	55-60	aquaporin 1 (Colton blood group)	Homo sapiens	77-88
10414857-0	1999	Expression of aquaporin 1 (AQP1) water channels in human labial salivary glands.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	14-25
10414857-0	1999	Expression of aquaporin 1 (AQP1) water channels in human labial salivary glands.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	27-31
10232700-1	1999	Several aquaporin-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the collecting duct; AQP6 in the papilla; and AQP7 in the proximal tubule.	Water	23-28	aquaporin 3	Mus musculus	145-149
10232700-1	1999	Several aquaporin-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the collecting duct; AQP6 in the papilla; and AQP7 in the proximal tubule.	Water	23-28	aquaporin 6	Mus musculus	184-188
10235127-3	1999	In rats subjected to water immersion restraint stress over a 6-hour period, the concentration of gastric mucosal nitrite/nitrate, breakdown products of NO, increased with the development of gastric mucosal lesions and a decrease in cNOS activity and a drastic increase in iNOS activity in the gastric mucosal tissue.	Water	21-26	nitric oxide synthase 2	Rattus norvegicus	272-276
10399677-5	1999	The imidazole compound increased ANGII-induced water intake suggesting its AT1 receptor agonistic properties.	Water	47-52	angiotensinogen	Rattus norvegicus	33-38
10399677-6	1999	PD 123319 inhibited ANGII-induced water intake at a higher dose (64 nmol), allowing to assume AT1 receptor agonistic properties.	Water	34-39	angiotensinogen	Rattus norvegicus	20-25
10231442-0	1999	High water intake ameliorates tubulointerstitial injury in rats with subtotal nephrectomy: possible role of TGF-beta.	Water	5-10	transforming growth factor, beta 1	Rattus norvegicus	108-116
10375960-5	1999	Aquaporin-2 (AQP-2) is an AVP-dependent water channel in renal collecting duct cells.	Water	40-45	arginine vasopressin	Homo sapiens	26-29
10344351-8	1999	An oral water load test revealed a highly significant (P &lt; 0.0001) inverse correlation between the plasma endothelin-1 concentrations and the ability to excrete a given water load.	Water	8-13	endothelin 1	Homo sapiens	109-121
10344351-8	1999	An oral water load test revealed a highly significant (P &lt; 0.0001) inverse correlation between the plasma endothelin-1 concentrations and the ability to excrete a given water load.	Water	172-177	endothelin 1	Homo sapiens	109-121
10344351-13	1999	We observed a highly significant inverse correlation between the plasma endothelin-1 concentrations and the ability to excrete a given water and sodium load, suggesting that the endothelin system plays a role in the regulation of water excretion in patients with liver cirrhosis.	Water	135-140	endothelin 1	Homo sapiens	72-84
10344351-13	1999	We observed a highly significant inverse correlation between the plasma endothelin-1 concentrations and the ability to excrete a given water and sodium load, suggesting that the endothelin system plays a role in the regulation of water excretion in patients with liver cirrhosis.	Water	230-235	endothelin 1	Homo sapiens	72-84
10361429-3	1999	Angiotensin II in the brain increases water and sodium intake, raises blood pressure, attenuates baro-reflex function, and increases vasopressin secretion.	Water	38-43	angiotensinogen	Homo sapiens	0-14
10400164-4	1999	The control group comprised rats that drank tap water after subtotal nephrectomy.	Water	48-53	nuclear RNA export factor 1	Rattus norvegicus	44-47
10206998-2	1999	Subsequent studies have shown that CFTR activates an endogenous water permeability in oocytes, but that CFTR itself is not the water channel.	Water	64-69	CF transmembrane conductance regulator	Homo sapiens	35-39
11864472-0	1999	[Evaluation of potential harmful effects of organic pollutants in tap water on mice in vivo].	Water	70-75	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	66-69
11864472-4	1999	RESULTS: Micronucleus rate and chromosome aberration rate increased by 1.7 and 3.5 folds, respectively, after administration of high dose of organic pollutants from the tap water (200 liters of tap water per kilograms of body weight) for three days.	Water	173-178	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	169-172
11864472-4	1999	RESULTS: Micronucleus rate and chromosome aberration rate increased by 1.7 and 3.5 folds, respectively, after administration of high dose of organic pollutants from the tap water (200 liters of tap water per kilograms of body weight) for three days.	Water	173-178	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	194-197
11864472-4	1999	RESULTS: Micronucleus rate and chromosome aberration rate increased by 1.7 and 3.5 folds, respectively, after administration of high dose of organic pollutants from the tap water (200 liters of tap water per kilograms of body weight) for three days.	Water	198-203	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	169-172
11864472-4	1999	RESULTS: Micronucleus rate and chromosome aberration rate increased by 1.7 and 3.5 folds, respectively, after administration of high dose of organic pollutants from the tap water (200 liters of tap water per kilograms of body weight) for three days.	Water	198-203	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	194-197
11864472-6	1999	In addition, organic concentrates from tap water also could significantly induce the activity of EROD, with a good dose-dependent relationship.	Water	43-48	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	39-42
11864472-7	1999	CONCLUSION: Organic concentrates from tap water could cause chromosome damage to somatic and germ cells and decrease in immune functions in the mice, as well as they could induce the activity of cytochrome P448 in the liver microsome.	Water	42-47	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	38-41
10350055-0	1999	Water-soluble 2,3,7,8-tetrachlorodibenzo-p-dioxin complex with human alpha-fetoprotein: properties, toxicity in vivo and antitumor activity in vitro.	Water	0-5	alpha fetoprotein	Homo sapiens	69-86
10343396-3	1999	In the former case, OGCHI was bound to N,N"-disuccinimidyl carbonate-activated aminopropyl-silica gels, while in the latter case OGCHI activated by a water-soluble carbodiimide and N-hydroxysulfosuccinimide was bound to aminopropyl-silica gels.	Water	150-155	orosomucoid 1 (ovoglycoprotein)	Gallus gallus	20-25
10343396-3	1999	In the former case, OGCHI was bound to N,N"-disuccinimidyl carbonate-activated aminopropyl-silica gels, while in the latter case OGCHI activated by a water-soluble carbodiimide and N-hydroxysulfosuccinimide was bound to aminopropyl-silica gels.	Water	150-155	orosomucoid 1 (ovoglycoprotein)	Gallus gallus	129-134
10206998-3	1999	Here, we show CFTR-dependent activation of endogenous water permeability in normal but not in cystic fibrosis human airway epithelial cells.	Water	54-59	CF transmembrane conductance regulator	Homo sapiens	14-18
10206998-5	1999	Glycerol uptake and antisense studies suggest CFTR-dependent regulation of aquaporin 3 (AQP3) water channels in airway epithelial cells.	Water	94-99	CF transmembrane conductance regulator	Homo sapiens	46-50
10327623-11	1999	It was found that effects of salt dominated over the temperature effect for the water-soluble proteins lysozyme, bovine serum albumin and cytochrome c.	Water	80-85	albumin	Homo sapiens	120-133
10327170-5	1999	Analysis of behavioral performance in the Morris water maze showed that while apolipoprotein E-deficient mice performed poorly, overexpression of apolipoprotein-E3 and, to a lower extent apolipoprotein-E4, resulted in an improved performance.	Water	49-54	apolipoprotein E	Homo sapiens	146-163
10327156-4	1999	MCAO was accomplished by an insertion of nylon thread with silicone coating for 24 h. Application of anti-P-selectin antibody significantly reduced infarct size and brain water content at 24 h of MCAO.	Water	171-176	selectin P	Rattus norvegicus	106-116
10327623-11	1999	It was found that effects of salt dominated over the temperature effect for the water-soluble proteins lysozyme, bovine serum albumin and cytochrome c.	Water	80-85	cytochrome c, somatic	Homo sapiens	138-150
10320046-1	1999	Newly developed antiviral compounds consisting of an adamantane derivative chemically linked to a water-soluble polyanionic matrix were shown to inhibit HIV-1 infection in lymphoblastoid cells, HeLa CD4+ beta-galactosidase (MAGI) cells and macrophages.	Water	98-103	CD4 molecule	Homo sapiens	199-202
10097254-6	1999	During the experimental period, body weight gain was greater in the insulin-treated groups than in the control groups whereas water intake was considerably decreased in the insulin-treated groups.	Water	126-131	insulin	Homo sapiens	173-180
10319425-1	1999	The sodium hydrogen exchanger isoform, NHE-1 plays an important role in electrolyte and water homeostasis.	Water	88-93	solute carrier family 9 member A1	Homo sapiens	39-44
10319425-8	1999	Suppression of NHE-1 might render the placenta with impaired uptake of water and electrolytes and therefore may be involved in the pathogenesis of preeclampsia.	Water	71-76	solute carrier family 9 member A1	Homo sapiens	15-20
10999014-10	1999	Gastric emptying of the water load was significantly delayed by the GLP-1 infusion.	Water	24-29	glucagon	Homo sapiens	68-73
10191086-3	1999	Expression in Xenopus oocytes indicated that Aqp2 encoded a mercurial-sensitive, water-selective channel.	Water	81-86	aquaporin 2 S homeolog	Xenopus laevis	45-49
10103067-10	1999	CD measurements for calmodulin in buffered solution revealed that its alpha-helical content was significantly higher than that for calmodulin in acetonitrile/water solutions, consistent with a proposition that changes in charge state distributions observed in the MS experiments reflect differing states of calmodulin folding.	Water	158-163	calmodulin 1	Homo sapiens	20-30
10103131-8	1999	Furthermore, FGF-5, when infused into the third ventricle, consistently reduced food intake, water intake and body weight gain, all in a dose-dependent manner.	Water	93-98	fibroblast growth factor 5	Rattus norvegicus	13-18
10103067-9	1999	With the use of denaturing solutions (1 : 1 acetonitrile/water + 1% formic acid), relatively high charge states (20 &lt; z &lt; 10) of monomeric calmodulin ions were detected, whereas when calmodulin was electrosprayed from buffer, monomers ions with only 5-10 charges were detected.	Water	57-62	calmodulin 1	Homo sapiens	145-155
10191086-8	1999	The mutant Aqp2-T126M was water permeable when expressed in Xenopus oocytes, but was retained at the endoplasmic reticulum (ER) in transfected mammalian cells.	Water	26-31	aquaporin 2 S homeolog	Xenopus laevis	11-15
10102286-3	1999	RESULTS: Binding of lysozyme to high-water-content, ionic contact lenses (etafilcon A and vifilcon A) was dominated by a penetration process.	Water	37-42	lysozyme	Homo sapiens	20-28
10203352-10	1999	Blood values of arginine vasopressin and aldosterone were significantly increased by water deprivation, whereas they were unchanged by water overloading.	Water	85-90	arginine vasopressin	Rattus norvegicus	25-36
10102291-11	1999	Rolipram inhibited EAU in IL-10 knockout mice equally well compared with controls and suppressed their primed lymph node cells in culture.	Water	19-22	interleukin 10	Mus musculus	26-31
10413917-1	1999	UNLABELLED: The acute phase response (APR) is characterized by proteolysis with decreased body cell mass, hyperglycemia, body water retention and renal dysfunction, which we hypothesised could affect magnesium serum levels.	Water	126-131	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	38-41
10457613-3	1999	The control group received solid diet (Purina rat chow) and tap water ad libitum.	Water	64-69	nuclear RNA export factor 1	Rattus norvegicus	60-63
10211818-6	1999	The ability of WAT1 to form four hydrogen bonds may explain why evolution has preserved a water molecule, rather than a side-chain atom, at the center of this intricate hydrogen bond network.	Water	90-95	MTOR associated protein, LST8 homolog	Homo sapiens	15-19
10372513-7	1999	Phenylephrine increased the dipsogenic responses produced by ANG II, whereas previous treatment with clonidine injected into the LH reduced the water intake induced by ANG II administration into the SFO.	Water	144-149	angiotensinogen	Homo sapiens	168-174
10399883-5	1999	P450AROM concentrations measured by [11C]vorozole binding correlated positively with aromatisation of [1beta-3H]androst-4-ene-3,17-dione measured as [3H]water release, and a positive association was also found with the ovarian in vivo response to follicle-stimulating hormone (FSH) stimulation expressed as 1000 times the ratio of the number of oocytes recovered from a patient and the total dose of recombinant FSH administered.	Water	153-158	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-8
10372513-0	1999	Effects of the alpha antagonists and agonists injected into the lateral hypothalamus on the water and sodium intake induced by angiotensin II injection into the subfornical organ.	Water	92-97	angiotensinogen	Homo sapiens	127-141
10372513-1	1999	The subfornical organ (SFO) and the lateral hypothalamus (LH) have been shown to be important for the central action of angiotensin II (ANG II) on water and salt regulation.	Water	147-152	angiotensinogen	Homo sapiens	120-134
10049533-1	1999	The SN2 reaction of Br- with methylnaphthalene-2-sulfonate (MeONs) in water is accelerated by micelles of tetradecyldialkyl amine oxide (alkyl = methyl, n-propyl) and rates increase sharply in HBr due to increased binding of Br- to the protonated amine oxide.	Water	70-75	solute carrier family 38 member 5	Homo sapiens	4-7
10070029-4	1999	With the use of 3-O-[3H]methyl-D-glucose to determine water space, AVP treatment resulted in significantly increased 3-O-methyl-D-glucose water space within 30 s of hypotonic exposure (P = 0.0001) and remained significantly elevated above baseline (1.	Water	54-59	arginine vasopressin	Homo sapiens	67-70
10066748-7	1999	Small angle neutron scattering measurements on the lacDNA.CRP(cAMP)2 complex in D2O/H2O mixtures show that the DNA is bent around the cAMP-ligated protein in solution.	Water	84-87	C-reactive protein	Homo sapiens	58-61
10066454-2	1999	NaCl and D(+)-raffinose increased (2-2.5 fold) AQP-1 expression when medium osmolarity was 400 and 500 mOsm/kg.H2O.	Water	111-114	aquaporin 1 (Colton blood group)	Homo sapiens	47-52
10066454-5	1999	Furthermore, HRPTE cells increased (3-4 fold) AQP-1 expression when exposed to hyperosmolar Reno-60 and Hypaque-76 (diatrizoates, ionic) contrast agents at 400 and 500 mOsm/kg.H2O.	Water	176-179	aquaporin 1 (Colton blood group)	Homo sapiens	46-51
10066454-6	1999	Isosmolar (290 mOsm/kg H2O) Visipaque (iodixanol, non-ionic) at 10% (v/v) concentrations also increased AQP-1 expression, and 25% v/v of Visipaque rendered morphological alterations of HRPTE cells and a 3-fold increase in AQP-1 expression after 24h exposure.	Water	23-26	aquaporin 1 (Colton blood group)	Homo sapiens	104-109
10372513-1	1999	The subfornical organ (SFO) and the lateral hypothalamus (LH) have been shown to be important for the central action of angiotensin II (ANG II) on water and salt regulation.	Water	147-152	angiotensinogen	Homo sapiens	136-142
10372513-3	1999	The present experiments were conducted to investigate the role of the alpha-adrenergic antagonists and agonists injected into the LH on the water and salt intake elicited by injections of ANG II into the SFO.	Water	140-145	angiotensinogen	Homo sapiens	188-194
10372513-6	1999	Previous treatment with prazosin and propranolol reduced the water intake induced by ANG II.	Water	61-66	angiotensinogen	Homo sapiens	85-91
10070029-4	1999	With the use of 3-O-[3H]methyl-D-glucose to determine water space, AVP treatment resulted in significantly increased 3-O-methyl-D-glucose water space within 30 s of hypotonic exposure (P = 0.0001) and remained significantly elevated above baseline (1.	Water	138-143	arginine vasopressin	Homo sapiens	67-70
10070029-17	1999	Taken together, these data suggest that AVP treatment of brain astrocytes in culture appears to increase 3-O-methyl-D-glucose water space during RVD through V1 receptor-mediated mechanisms.	Water	126-131	arginine vasopressin	Homo sapiens	40-43
9952318-3	1999	We concluded that cis-platinum accelerated the generation of superoxide anion in the cells, and the superoxide anion produced was converted into H2O by the cooperative roles of catalase and Cu,Zn-SOD.	Water	145-148	catalase	Homo sapiens	177-185
9952318-3	1999	We concluded that cis-platinum accelerated the generation of superoxide anion in the cells, and the superoxide anion produced was converted into H2O by the cooperative roles of catalase and Cu,Zn-SOD.	Water	145-148	superoxide dismutase 1	Homo sapiens	190-199
9973596-2	1999	Additionally, two water-soluble proteins, transketolase (TKT) and aldehyde dehydrogenase class 1 (ALDH1), isolated from rabbit keratocytes showed unexpectedly abundant expression ( approximately 30% of the soluble protein) in transparent corneas and markedly reduced levels in opaque scleral fibroblasts or keratocytes from hazy, freeze injured regions of the cornea.	Water	18-23	transketolase	Oryctolagus cuniculus	42-55
10073616-3	1999	Aquaporin-1 (AQP1) is extremely abundant in the proximal tubule and descending thin limb, where it appears to provide the chief route for proximal nephron water reabsorption.	Water	155-160	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
10073616-3	1999	Aquaporin-1 (AQP1) is extremely abundant in the proximal tubule and descending thin limb, where it appears to provide the chief route for proximal nephron water reabsorption.	Water	155-160	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
10073616-4	1999	AQP2 is abundant in the collecting duct principal cells and is the chief target for vasopressin to regulate collecting duct water reabsorption.	Water	124-129	arginine vasopressin	Homo sapiens	84-95
10212383-1	1999	Arginine vasopressin (AVP) has a dual action, i.e. vasoconstriction and water reabsorption via V1A and V2 receptors, and may play a role in a number of diseases, including congestive heart failure (CHF), hypertension, renal disease, edema, and hyponatremia.	Water	72-77	arginine vasopressin	Homo sapiens	9-20
9973596-2	1999	Additionally, two water-soluble proteins, transketolase (TKT) and aldehyde dehydrogenase class 1 (ALDH1), isolated from rabbit keratocytes showed unexpectedly abundant expression ( approximately 30% of the soluble protein) in transparent corneas and markedly reduced levels in opaque scleral fibroblasts or keratocytes from hazy, freeze injured regions of the cornea.	Water	18-23	transketolase	Oryctolagus cuniculus	57-60
10067735-13	1999	Growth hormone may have therapeutic potential in intestinal diseases characterized by epithelial atrophy and loss of water and electrolytes.	Water	117-122	growth hormone 1	Homo sapiens	0-14
10231710-1	1999	The solution structure of a biologically active modified linear endothelin-1 analogue, ET1-21[Cys(Acm)1,15, Aib3,11, Leu7], has been determined for the first time by two-dimensional nuclear magnetic resonance spectroscopy in a methanol-d3/water solvent mixture.	Water	239-244	endothelin 1	Homo sapiens	64-76
10231710-1	1999	The solution structure of a biologically active modified linear endothelin-1 analogue, ET1-21[Cys(Acm)1,15, Aib3,11, Leu7], has been determined for the first time by two-dimensional nuclear magnetic resonance spectroscopy in a methanol-d3/water solvent mixture.	Water	239-244	endothelin 1	Homo sapiens	87-90
10199162-4	1999	CaSR may also play a role in water metabolism.	Water	29-34	calcium sensing receptor	Homo sapiens	0-4
10333361-9	1999	HS + IL-8 treatment caused cervices to increase their water content and become oedematous.	Water	54-59	interleukin-8	Oryctolagus cuniculus	5-9
10077841-2	1999	We report that deletion of the NHA1 gene resulted in an increase of cytoplasmic pH in cells suspended in water or acidic buffers.	Water	105-110	Nha1p	Saccharomyces cerevisiae S288C	31-35
10358994-6	1999	65 patients with dumping-syndrome following a course of drinking mineral water demonstrated improvement in clinical symptoms of the disease and changed hormonal response to glucose which manifested with activation of insulin secretion early phase and reduced rise of hydrocortisone levels.	Water	73-78	insulin	Homo sapiens	217-224
9988736-1	1999	The antidiuretic hormone arginine-vasopressin (AVP) regulates water reabsorption in renal collecting duct principal cells by inducing a cAMP-dependent translocation of water channels (aquaporin-2, AQP-2) from intracellular vesicles into the apical cell membranes.	Water	62-67	arginine vasopressin	Rattus norvegicus	34-45
9990012-1	1999	Hen egg-white lysozyme dissolved in glycerol containing 1% water was studied by using CD and amide proton exchange monitored by two-dimensional 1H NMR.	Water	59-64	lysozyme	Homo sapiens	14-22
9990012-2	1999	The far- and near-UV CD spectra of the protein showed that the secondary and tertiary structures of lysozyme in glycerol were similar to those in water.	Water	146-151	lysozyme	Homo sapiens	100-108
9990012-6	1999	The results point to a highly ordered, native-like structure of lysozyme in glycerol, with the stability exceeding that in water.	Water	123-128	lysozyme	Homo sapiens	64-72
9950956-1	1999	Aquaporin-2 (AQP2), the protein that mediates arginine vasopressin (AVP)-regulated apical water transport in the renal collecting duct, possesses a single consensus phosphorylation site for cAMP-dependent protein kinase A (PKA) at Ser256.	Water	90-95	arginine vasopressin	Rattus norvegicus	55-66
9931478-5	1999	Water deprivation for 48 h, leading to extracellular hypertonic hypovolemia with elevated circulating AngII concentrations within the physiological range, caused a significant increase in AoGen-specific hybridization signals in the rostral and medial SFO regions.	Water	0-5	angiotensinogen	Rattus norvegicus	102-107
9931478-5	1999	Water deprivation for 48 h, leading to extracellular hypertonic hypovolemia with elevated circulating AngII concentrations within the physiological range, caused a significant increase in AoGen-specific hybridization signals in the rostral and medial SFO regions.	Water	0-5	angiotensinogen	Rattus norvegicus	188-193
9931262-0	1999	Water molecules in the binding cavity of intestinal fatty acid binding protein: dynamic characterization by water 17O and 2H magnetic relaxation dispersion.	Water	0-5	fatty acid binding protein 2	Homo sapiens	41-78
9931262-0	1999	Water molecules in the binding cavity of intestinal fatty acid binding protein: dynamic characterization by water 17O and 2H magnetic relaxation dispersion.	Water	108-113	fatty acid binding protein 2	Homo sapiens	41-78
9931262-1	1999	The hydration of intestinal fatty acid binding protein (IFABP) in apo-form and complexed with palmitate, oleate, and 1-anilino-8-naphthalene sulfonate (ANS) has been studied by water 17O and 2H magnetic relaxation dispersion (MRD) measurements.	Water	177-182	fatty acid binding protein 2	Homo sapiens	17-54
9931262-1	1999	The hydration of intestinal fatty acid binding protein (IFABP) in apo-form and complexed with palmitate, oleate, and 1-anilino-8-naphthalene sulfonate (ANS) has been studied by water 17O and 2H magnetic relaxation dispersion (MRD) measurements.	Water	177-182	fatty acid binding protein 2	Homo sapiens	56-61
9950956-1	1999	Aquaporin-2 (AQP2), the protein that mediates arginine vasopressin (AVP)-regulated apical water transport in the renal collecting duct, possesses a single consensus phosphorylation site for cAMP-dependent protein kinase A (PKA) at Ser256.	Water	90-95	arginine vasopressin	Rattus norvegicus	68-71
9950956-11	1999	The results indicate that AVP stimulates phosphorylation of AQP2 at Ser256 via activation of PKA, supporting the idea that this is one of the first steps leading to increased water permeability in collecting duct cells.	Water	175-180	arginine vasopressin	Rattus norvegicus	26-29
9916024-10	1999	Furthermore, treatment with a water-permeable form of cholesterol that bypasses the requirement for StAR partially restored hCG-stimulated testosterone secretion from testes isolated from rats treated icv with IL-1beta.	Water	30-35	steroidogenic acute regulatory protein	Rattus norvegicus	100-104
10207612-2	1999	Moreover, benzene oxidation to water-soluble metabolites was suppressed by 0.1 mM diethyldithiocarbamate, supposedly a specific inhibitor of CYP2E1 at this level.	Water	31-36	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	141-147
9916024-10	1999	Furthermore, treatment with a water-permeable form of cholesterol that bypasses the requirement for StAR partially restored hCG-stimulated testosterone secretion from testes isolated from rats treated icv with IL-1beta.	Water	30-35	interleukin 1 beta	Rattus norvegicus	210-218
9916045-0	1999	Membrane dynamics of the water transport protein aquaporin-1 in intact human red cells.	Water	25-30	aquaporin 1 (Colton blood group)	Homo sapiens	49-60
9916045-1	1999	Aquaporin-1 (AQP1) is the prototype integral membrane protein water channel.	Water	62-67	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
10095951-0	1999	[Tap water magnesium deficiency modulate arterial blood pressure, Ca and Mg tissue distribution, and compartmentation of membrane-bound calcium in thrombocytes of normotensive WKY rats].	Water	5-10	nuclear RNA export factor 1	Rattus norvegicus	1-4
9916045-1	1999	Aquaporin-1 (AQP1) is the prototype integral membrane protein water channel.	Water	62-67	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
10063906-0	1999	Helicobacter pylori water extract induces interleukin-8 production by gastric epithelial cells.	Water	20-25	C-X-C motif chemokine ligand 8	Homo sapiens	42-55
10205677-7	1999	The large discrepancy of tissue distribution between hAQP9 and rAQP9L suggest that rAQP9L is a new aquaporin, which is involved in transport of urea as well as water in liver.	Water	160-165	aquaporin 9	Homo sapiens	53-58
10063906-3	1999	The aims of the present study were to determine whether an H. pylori water extract (HPE) induces IL-8 production by gastric epithelial cells and to characterize IL-8-inducing substances in HPE.	Water	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
9973310-2	1999	The liquid water and the water in the solution are in equilibrium when piH2Ol is the osmotic pressure of the water in the solution.	Water	11-16	PIH2	Homo sapiens	71-75
9973310-2	1999	The liquid water and the water in the solution are in equilibrium when piH2Ol is the osmotic pressure of the water in the solution.	Water	25-30	PIH2	Homo sapiens	71-75
9973310-2	1999	The liquid water and the water in the solution are in equilibrium when piH2Ol is the osmotic pressure of the water in the solution.	Water	25-30	PIH2	Homo sapiens	71-75
10195378-6	1999	ACTH levels decreased during the 5% dextrose in water and the EDTA infusions but increased during the calcium infusion.	Water	48-53	proopiomelanocortin	Homo sapiens	0-4
10021464-1	1999	The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia.	Water	29-34	aquaporin 1 (Colton blood group)	Homo sapiens	56-60
10023655-0	1999	Expression of aquaporin-1 in a long-term peritoneal dialysis patient with impaired transcellular water transport.	Water	97-102	aquaporin 1 (Colton blood group)	Homo sapiens	14-25
10023655-1	1999	Aquaporin-1 (AQP1) has been claimed to be the molecular counterpart of the transcellular pathway for free-water movement across the peritoneum during peritoneal dialysis.	Water	106-111	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
10023655-1	1999	Aquaporin-1 (AQP1) has been claimed to be the molecular counterpart of the transcellular pathway for free-water movement across the peritoneum during peritoneal dialysis.	Water	106-111	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
10023655-2	1999	We report the case of a 67-year-old man, on peritoneal dialysis for 11 years, in whom ultrafiltration failure due to an abolition of the transcellular water transfer (documented by a loss of sodium sieving) was associated with an apparently normal expression of AQP1.	Water	151-156	aquaporin 1 (Colton blood group)	Homo sapiens	262-266
9882643-10	1999	During systemic acidosis, apical gill NHE-2 (which is sensitive to external amiloride and low [Na+]) in parallel with a dramatic suppression of basolateral NHE-1 activity enhances net capdelta H+ transfers to the water.	Water	213-218	solute carrier family 9 member A1	Homo sapiens	156-161
10093213-2	1999	Fragment ions corresponding to the elimination of H2O and HN=C=NH are observed in the product ion mass spectra of Lys1-bradykinin and des-Arg1-bradykinin but not in the spectra of bradykinin or des-Arg9-bradykinin.	Water	50-53	kininogen 1	Homo sapiens	119-129
10093213-2	1999	Fragment ions corresponding to the elimination of H2O and HN=C=NH are observed in the product ion mass spectra of Lys1-bradykinin and des-Arg1-bradykinin but not in the spectra of bradykinin or des-Arg9-bradykinin.	Water	50-53	kininogen 1	Homo sapiens	143-153
10093213-2	1999	Fragment ions corresponding to the elimination of H2O and HN=C=NH are observed in the product ion mass spectra of Lys1-bradykinin and des-Arg1-bradykinin but not in the spectra of bradykinin or des-Arg9-bradykinin.	Water	50-53	kininogen 1	Homo sapiens	143-153
10093213-2	1999	Fragment ions corresponding to the elimination of H2O and HN=C=NH are observed in the product ion mass spectra of Lys1-bradykinin and des-Arg1-bradykinin but not in the spectra of bradykinin or des-Arg9-bradykinin.	Water	50-53	kininogen 1	Homo sapiens	143-153
10048334-1	1999	The serine protease subtilisin BPN" is a useful catalyst for peptide synthesis when dissolved in high concentrations of a water-miscible organic co-solvent such as N,N-dimethylformamide (DMF).	Water	122-127	coagulation factor II, thrombin	Homo sapiens	4-19
10063636-6	1999	The water in the by-pass section was then released into the main pipe-rig and sampled downstream.	Water	4-9	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	70-73
10063636-8	1999	Finally, the flow in the main pipe-rig and in the by-pass was increased to dislodge any deposits and biofilm into the water.	Water	118-123	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	35-38
10063642-1	1999	Helicobacter pylori NCTC 11637 produces a water-insoluble biofilm when grown under defined conditions with a high carbon:nitrogen ratio in continuous culture and in 10% strength Brucella broth supplemented with 3 g l-1 glucose.	Water	42-47	immunoglobulin kappa variable 1-16	Homo sapiens	215-218
9932713-4	1999	These results demonstrate the important role of vasopressin in the development of antidiuresis and disturbances in brain water and electrolyte balance in response to subarachnoid haemorrhage.	Water	121-126	arginine vasopressin	Homo sapiens	48-59
9915811-2	1999	The kinetics of PI-PLCgamma1 toward a water-soluble substrate (inositol 1,2-cyclic phosphate, cIP) and phosphatidylinositol (PI) in detergent mixed micelles were monitored by 31P NMR spectroscopy.	Water	38-43	phospholipase C gamma 1	Homo sapiens	19-28
9882456-6	1999	In contrast to the Alpha and Mu classes being selective for strongly electrophilic compounds, the neoplastic P1-1 species was indicated to be selective for weakly electrophilic and water-soluble carcinogens such as acrolein and hydroxyalkenals.	Water	181-186	S100 calcium binding protein A10	Homo sapiens	109-113
9888793-6	1999	The second Gal-beta1,4-GlcNAc-Epo moiety was recognized via the carbohydrate-carbohydrate interaction with the first Gal-beta1, 4-GlcNAc-Epo moiety in addition to the protein-carbohydrate interaction with the "right-side" catalytic cleft of HL through a number of hydrogen bonds including water-mediated ones as well as many van der Waals contacts.	Water	289-294	erythropoietin	Homo sapiens	30-33
9888793-6	1999	The second Gal-beta1,4-GlcNAc-Epo moiety was recognized via the carbohydrate-carbohydrate interaction with the first Gal-beta1, 4-GlcNAc-Epo moiety in addition to the protein-carbohydrate interaction with the "right-side" catalytic cleft of HL through a number of hydrogen bonds including water-mediated ones as well as many van der Waals contacts.	Water	289-294	erythropoietin	Homo sapiens	137-140
9878411-3	1999	A comparative two-dimensional NMR study of cytochrome b5 and its E44/56A mutant in water solution has been achieved.	Water	83-88	cytochrome b5 type A	Bos taurus	43-56
10389187-1	1999	A significant increase in the water permeability was found in the rat outer medullary collecting duct (OMCD) cells in presence of 10-7M of vasopressin.	Water	30-35	arginine vasopressin	Rattus norvegicus	139-150
9874779-1	1999	Water in the hydrophobic cavity of human interleukin 1beta, which was detected by NMR spectroscopy but was invisible by high resolution x-ray crystallography, has been mapped quantitatively by measurement and phasing of all of the low resolution x-ray diffraction data from a single crystal.	Water	0-5	interleukin 1 beta	Homo sapiens	41-58
10872456-1	1999	The high water permeability characteristic of mammalian red cell membranes is now known to be caused by the protein AQP1.	Water	9-14	aquaporin 1 (Colton blood group)	Homo sapiens	116-120
9887181-0	1999	Ovarian steroid regulation of angiotensin II-induced water intake in the rat.	Water	53-58	angiotensinogen	Rattus norvegicus	30-44
9887181-7	1999	A central interaction between the peptide hormone ANG II and estrogen, involving a genomic mechanism, may underlie the cyclicity in water intake behavior observed in the rat.	Water	132-137	angiotensinogen	Rattus norvegicus	50-56
10872456-7	1999	Orthodox aquaporins are water-selective and include AQP2, a vasopressin-regulated water channel in renal collecting duct, in addition to AQP0, AQP4, and AQP5.	Water	82-87	arginine vasopressin	Homo sapiens	60-71
10099706-0	1999	Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.	Water	35-40	arginine vasopressin	Homo sapiens	14-25
10872456-8	1999	Multifunctional aquaglyceroporins AQP3, AQP7, and AQP9 are permeated by water, glycerol, and some other solutes.	Water	72-77	aquaporin 9	Homo sapiens	50-54
10099706-1	1999	Vasopressin or AVP regulates water reabsorption by the kidney inner medullary collecting duct (IMCD) through the insertion and removal of aquaporin (AQP) 2 water channels into the IMCD apical membrane.	Water	29-34	arginine vasopressin	Homo sapiens	0-11
10099706-1	1999	Vasopressin or AVP regulates water reabsorption by the kidney inner medullary collecting duct (IMCD) through the insertion and removal of aquaporin (AQP) 2 water channels into the IMCD apical membrane.	Water	156-161	arginine vasopressin	Homo sapiens	0-11
10578095-5	1999	The partitioning behavior of three proteins (lysozyme, bovine serum albumin, and apolipoprotein A-1) in water/HM-EOPO two-phase systems has been studied, as well as the effect of various ions, pH, and temperature on protein partitioning.	Water	104-109	apolipoprotein A1	Homo sapiens	81-99
10883320-1	1999	Vasopressin and bradykinin are two of the most important peptides in regulating vascular tone, water, and ionic balance in the body, and thus they play a key role in controlling blood pressure.	Water	95-100	arginine vasopressin	Homo sapiens	0-11
10883320-1	1999	Vasopressin and bradykinin are two of the most important peptides in regulating vascular tone, water, and ionic balance in the body, and thus they play a key role in controlling blood pressure.	Water	95-100	kininogen 1	Homo sapiens	16-26
10883320-3	1999	We review here the primary evidence for the localization of the vasopressin and kinin receptors and their role in ionic and water regulation in the kidney.	Water	124-129	arginine vasopressin	Homo sapiens	64-75
11068827-0	1999	Photochemical mineralization of synthetic lignin in lake water indicates enhanced turnover of aromatic organic matter under solar radiation The degradation of 14C-[ring]-labelled synthetic lignin (14C-DHP) and dissolved organic carbon (DOC) from lake water were studied simultaneously.	Water	57-62	dihydropyrimidinase	Homo sapiens	201-204
11068827-0	1999	Photochemical mineralization of synthetic lignin in lake water indicates enhanced turnover of aromatic organic matter under solar radiation The degradation of 14C-[ring]-labelled synthetic lignin (14C-DHP) and dissolved organic carbon (DOC) from lake water were studied simultaneously.	Water	251-256	dihydropyrimidinase	Homo sapiens	201-204
11068827-3	1999	Under solar radiation (116 MJ m(-2)), 17-21% of the 14C-labelled carbons in DHP and 18-23% of the indigenous DOC were mineralized in 7 d. Simultaneously the water solubility of 14C-DHP increased.	Water	157-162	dihydropyrimidinase	Homo sapiens	181-184
27393255-0	1999	Spectrophotometric Assay for Superoxide Dismutase Based on the Reduction of Highly Water-soluble Tetrazolium Salts by Xanthine-Xanthine Oxidase.	Water	83-88	superoxide dismutase 1	Homo sapiens	29-49
10578095-13	1999	By adding a new water/buffer phase at higher pH and with 100 mM NaClO(4), and raising the temperature for separation, the apolipoprotein A-1 could be back-extracted from the HM-EOPO phase into the new water phase.	Water	16-21	apolipoprotein A1	Homo sapiens	122-140
10578095-13	1999	By adding a new water/buffer phase at higher pH and with 100 mM NaClO(4), and raising the temperature for separation, the apolipoprotein A-1 could be back-extracted from the HM-EOPO phase into the new water phase.	Water	201-206	apolipoprotein A1	Homo sapiens	122-140
10037245-2	1999	To investigate if the water retaining effect of GH persists for a longer time we examined the impact of 4 months GH treatment on extracellular volume (ECV) and plasma volume (PV) in GH deficient adults.	Water	22-27	growth hormone 1	Homo sapiens	48-50
10394626-3	1999	MBP has been extensively studied in its water-soluble form, but it is also known in a detergent-soluble form, which is purified with endogenous myelin lipids and should correspond to the native form of the protein in the membrane.	Water	40-45	myelin basic protein	Bos taurus	0-3
10460343-0	1999	Molecular dynamics simulation of alpha-melanocyte stimulating hormone in a water-membrane model interface.	Water	75-80	proopiomelanocortin	Homo sapiens	33-69
10460343-1	1999	The conformation of the tridecapeptide alpha-melanocyte stimulating hormone in the presence of a double water-membrane interface was studied by molecular dynamics simulation, using the computational package THOR.	Water	104-109	proopiomelanocortin	Homo sapiens	39-75
10701203-11	1999	Unprotected well water was the cause of 59.2 p. 100 of diarrheal episodes reported by gardeners at Tel Zatar.	Water	17-22	ETS variant transcription factor 6	Homo sapiens	99-102
9892151-11	1999	These effects on water handling are consistent with previous findings that chronic angiotensin II inhibition inhibits water reabsorption in the kidney.	Water	17-22	angiotensinogen	Rattus norvegicus	83-97
9892151-11	1999	These effects on water handling are consistent with previous findings that chronic angiotensin II inhibition inhibits water reabsorption in the kidney.	Water	118-123	angiotensinogen	Rattus norvegicus	83-97
10702726-9	1999	ISIS 2922 only partially inhibited the upregulation of IL-8 in infected cells treated with H(2)O(2), whereas cotreatment with ISIS 2922 and antioxidants inhibited the upregulation almost completely.	Water	91-96	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
10100486-0	1999	Principal cells of the vas deferens are involved in water transport and steroid synthesis in the adult rat.	Water	52-57	arginine vasopressin	Rattus norvegicus	23-26
10100486-8	1999	Taken together, these observations suggested water transport from the lumen of the vas deferens via the dilated spaces to underlying vascular channels, the function of which may be to concentrate sperm.	Water	45-50	arginine vasopressin	Rattus norvegicus	83-86
10100486-15	1999	In summary, principal cells of the vas deferens appear to be involved in synthesis and secretion of steroids and in eliminating water from the lumen of the vas deferens.	Water	128-133	arginine vasopressin	Rattus norvegicus	35-38
10100486-15	1999	In summary, principal cells of the vas deferens appear to be involved in synthesis and secretion of steroids and in eliminating water from the lumen of the vas deferens.	Water	128-133	arginine vasopressin	Rattus norvegicus	156-159
10445046-1	1999	Dimethyl sulfoxide (DMSO), a solvent popularly used for dissolving water-insoluble compounds, is a weak inhibitor of poly(ADP-ribose) synthetase, that is a nuclear enzyme producing (ADP-ribose)n from NAD+.	Water	67-72	poly(ADP-ribose) polymerase 1	Homo sapiens	117-144
9972502-2	1999	The preparation process was further developed in the present study to reduce the particle size and to increase the loading capacity of brilliant blue, bovine serum albumin (BSA) and tumour necrosis factor-alpha (TNF-alpha) which were used as water soluble model drug substances.	Water	242-247	tumor necrosis factor	Homo sapiens	212-221
9864411-0	1999	A polyclonal antibody against synthetic peptide conserved in N-Myc protein reacts with water-soluble recombinant N-Myc protein.	Water	87-92	MYCN proto-oncogene, bHLH transcription factor	Rattus norvegicus	61-66
10609609-1	1999	The active entity responsible for inducing interleukin-6 production by human gingival fibroblasts was partially purified by ion-exchange chromatography from the water-soluble fraction of Mycoplasma salivarium cells.	Water	161-166	interleukin 6	Homo sapiens	43-56
10207260-9	1999	GH may also raise preload through its sodium-retaining action and its interference with the hormonal system that regulates water and electrolyte metabolism.	Water	123-128	growth hormone 1	Homo sapiens	0-2
10614048-7	1999	MAS-NMR analysis of [15N]lysine-labelled rhodopsin reveals the presence of a "soft" counterion, requiring intermediate water molecules for stabilization.	Water	119-124	rhodopsin	Homo sapiens	41-50
9894975-1	1999	OBJECTIVE: Recent experimental evidence suggests that centrally released arginine vasopressin plays a significant role in brain capillary water permeability as well as in pathogenesis of vasogenic brain edema.	Water	138-143	arginine vasopressin	Rattus norvegicus	82-93
9864411-0	1999	A polyclonal antibody against synthetic peptide conserved in N-Myc protein reacts with water-soluble recombinant N-Myc protein.	Water	87-92	MYCN proto-oncogene, bHLH transcription factor	Rattus norvegicus	113-118
9864411-2	1999	We attempted to obtain a water-soluble N-Myc protein, and an antibody highly specific for the N-Myc protein.	Water	25-30	MYCN proto-oncogene, bHLH transcription factor	Rattus norvegicus	39-44
9864411-4	1999	Newly obtained N-Myc (rN-Myc) was water-soluble with a M.W.	Water	34-39	MYCN proto-oncogene, bHLH transcription factor	Rattus norvegicus	15-20
9864411-4	1999	Newly obtained N-Myc (rN-Myc) was water-soluble with a M.W.	Water	34-39	MYCN proto-oncogene, bHLH transcription factor	Rattus norvegicus	22-28
9922383-11	1999	At the airway surface, deletion of CFTR causes hyperabsorption of sodium chloride and a reduction in the periciliary salt and water content, which impairs mucociliary clearance.	Water	126-131	CF transmembrane conductance regulator	Homo sapiens	35-39
9922383-12	1999	In submucosal glands, loss of CFTR-mediated salt and water secretion compromises the clearance of mucins and a variety of defense substances onto the airway surface.	Water	53-58	CF transmembrane conductance regulator	Homo sapiens	30-34
10573789-0	1999	Effects of water balance, diet and antidiuretic-hormone administration on the renal excretion of water.	Water	97-102	arginine vasopressin	Homo sapiens	35-55
10578499-1	1999	The purpose of this work was to examine the sorption and desorption of water by various samples of microcrystalline cellulose, MCC (Avicel PH-101), taken from the extrusion/marumerization process, and to provide data that may explain how water affects the MCC polymer matrix during the formation of beads.	Water	71-76	MCC regulator of WNT signaling pathway	Homo sapiens	127-130
10578499-1	1999	The purpose of this work was to examine the sorption and desorption of water by various samples of microcrystalline cellulose, MCC (Avicel PH-101), taken from the extrusion/marumerization process, and to provide data that may explain how water affects the MCC polymer matrix during the formation of beads.	Water	71-76	MCC regulator of WNT signaling pathway	Homo sapiens	256-259
10578499-9	1999	The results suggest that the internal structure of the MCC polymer fibers must change with the sorption and desorption of water, supporting the autohesion theory.	Water	122-127	MCC regulator of WNT signaling pathway	Homo sapiens	55-58
10375953-0	1999	[Renal renin-angiotensin system in homeostatic water-electrolyte regulation].	Water	47-52	renin	Homo sapiens	7-12
10526369-1	1999	Three-dimensional (3D) models of four CASP3 targets were calculated using a simple modeling procedure that includes prediction of regular secondary structure, analysis of possible beta-sheet topologies, assembly of amphiphilic helices and beta-sheets to bury their nonpolar surfaces, and adjustment of side-chain conformers and loops to provide close packing and saturation of the "hydrogen bond potential" (exposure of all polar groups to water or their involvement in intramolecular hydrogen bonds).	Water	440-445	caspase 3	Homo sapiens	38-43
9920380-1	1998	The structure of a synthesized peptide with the sequence of NHILPNESAYDQKNIRRRVYDALNVLMAMNIISK that corresponds to residues 151-184 of transcription factor DP-1 (Girling et al., Nature 362 (1993) 83-87) was determined by 1H-nuclear magnetic resonance in water and 40% d3-trifluoroethanol/water, respectively.	Water	254-259	transcription factor Dp-1	Homo sapiens	156-160
10101953-0	1999	Selective COX-2 inhibitors: is the water becoming muddy?	Water	35-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
9918778-6	1998	The alpha-helical structure of the peptide in the TFE/H2O cosolvent was found to be identical to that in the crystal structure of intact cyclin A.	Water	54-57	cyclin A2	Homo sapiens	137-145
9874275-1	1998	Aquaporin 1 (AQP1) is the archetypal member of a family of integral membrane proteins that function as water channels.	Water	103-108	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
9874275-1	1998	Aquaporin 1 (AQP1) is the archetypal member of a family of integral membrane proteins that function as water channels.	Water	103-108	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
10380284-1	1999	Structural changes in organization of the microtubule system in granular cells of frog urinary bladder after water transport induction by vasopressin were studied by methods of electron microscopy and immunocytochemistry.	Water	109-114	arginine vasopressin	Homo sapiens	138-149
9837877-3	1998	To determine the roles of lipid composition and the aquaporin 1 (AQP1) water channel in altering CO2 flux across membranes, we developed a fluorometric assay to measure CO2 entry into vesicles.	Water	71-76	aquaporin 1 (Colton blood group)	Homo sapiens	52-63
9837877-3	1998	To determine the roles of lipid composition and the aquaporin 1 (AQP1) water channel in altering CO2 flux across membranes, we developed a fluorometric assay to measure CO2 entry into vesicles.	Water	71-76	aquaporin 1 (Colton blood group)	Homo sapiens	65-69
9837877-6	1998	When AQP1 purified from human red blood cells was reconstituted into proteoliposomes, however, it increased water and CO2 permeabilities markedly.	Water	108-113	aquaporin 1 (Colton blood group)	Homo sapiens	5-9
9837877-9	1998	AQP1 clearly serves to increase CO2 permeation, likely through the water pore; under certain circumstances, gas permeation through membranes is protein-mediated.	Water	67-72	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
9920380-1	1998	The structure of a synthesized peptide with the sequence of NHILPNESAYDQKNIRRRVYDALNVLMAMNIISK that corresponds to residues 151-184 of transcription factor DP-1 (Girling et al., Nature 362 (1993) 83-87) was determined by 1H-nuclear magnetic resonance in water and 40% d3-trifluoroethanol/water, respectively.	Water	288-293	transcription factor Dp-1	Homo sapiens	156-160
9843718-3	1998	Immunofluorescence demonstrated that in isolated cells the Na+-K+-ATPase, Na+-K+-2Cl- cotransporter, and aquaporin 1 water channel remained localized to the brush border, whereas the Cl-/HCO-3 (anion) exchanger type 2 was confined to the basolateral membrane.	Water	117-122	aquaporin 1 (Colton blood group)	Homo sapiens	105-116
9920685-6	1998	A physiological role for ANG II in water intake induced by sodium depletion has recently been disputed, but the simplest explanation for the data remains that elevated levels of circulating ANG II bind to receptors in the SFO to generate daytime water drinking during sodium depletion.	Water	35-40	angiotensinogen	Rattus norvegicus	190-196
9920685-6	1998	A physiological role for ANG II in water intake induced by sodium depletion has recently been disputed, but the simplest explanation for the data remains that elevated levels of circulating ANG II bind to receptors in the SFO to generate daytime water drinking during sodium depletion.	Water	246-251	angiotensinogen	Rattus norvegicus	190-196
10052722-5	1998	L-NAME (0.5 g/L in drinking water) caused further enhancement of the angiogenic response produced by human recombinant bFGF (p&lt;0.001), bovine purified bFGF (p&lt;0.05) or murine recombinant IL-1 (p&lt;0.05).	Water	28-33	fibroblast growth factor 2	Homo sapiens	119-123
9951557-0	1998	Role of angiotensin II and vasopressin receptors within the supraoptic nucleus in water and sodium intake induced by the injection of angiotensin II into the medial septal area.	Water	82-87	angiotensinogen	Rattus norvegicus	8-22
10052722-5	1998	L-NAME (0.5 g/L in drinking water) caused further enhancement of the angiogenic response produced by human recombinant bFGF (p&lt;0.001), bovine purified bFGF (p&lt;0.05) or murine recombinant IL-1 (p&lt;0.05).	Water	28-33	fibroblast growth factor 2	Bos taurus	154-158
9951557-0	1998	Role of angiotensin II and vasopressin receptors within the supraoptic nucleus in water and sodium intake induced by the injection of angiotensin II into the medial septal area.	Water	82-87	angiotensinogen	Rattus norvegicus	134-148
9951557-9	1998	These results suggest that both AT1 and V1 receptors within the SON may be involved in water and sodium intake induced by the activation of ANG II receptors within the MSA.	Water	87-92	angiotensinogen	Rattus norvegicus	140-146
9854715-3	1998	Thrombin (1000 U) was dissolved (0.8 sterile water, 0.2 ml aminocaproic acid) and warmed (37 C).	Water	45-50	coagulation factor II, thrombin	Homo sapiens	0-8
9891258-0	1998	Isolation and identification of some major water-soluble peptides in Feta cheese.	Water	43-48	alpha fetoprotein	Homo sapiens	69-73
9891258-1	1998	Peptides were isolated from the water-soluble fraction of Feta cheese by reversed-phase HPLC in three successive steps.	Water	32-37	alpha fetoprotein	Homo sapiens	58-62
9891258-6	1998	beta-Lactoglobulin and alpha-lactalbumin were also identified in the water extract of Feta cheese.	Water	69-74	lactalbumin alpha	Homo sapiens	23-40
9891258-6	1998	beta-Lactoglobulin and alpha-lactalbumin were also identified in the water extract of Feta cheese.	Water	69-74	alpha fetoprotein	Homo sapiens	86-90
9865924-4	1998	RH1, a water-soluble analogue of MeDZQ synthesized in this work, was a better substrate for recombinant human NQO1 than the parent compound.	Water	7-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	110-114
9837854-4	1998	We now demonstrate by RNase protection analysis, Western blot, and immunohistochemistry that the expression of NOS II mRNA and protein is markedly induced in colonic enterocytes of mice that ingest LPS with their drinking water.	Water	222-227	nitric oxide synthase 2, inducible	Mus musculus	111-117
9848772-3	1998	Dysregulation of aquaporin-2 (AQP2), the predominant vasopressin-regulated water channel, is known to be associated with a range of congenital and acquired water balance disorders including nephrogenic diabetes insipidus and states of water retention.	Water	75-80	arginine vasopressin	Rattus norvegicus	53-64
9848772-3	1998	Dysregulation of aquaporin-2 (AQP2), the predominant vasopressin-regulated water channel, is known to be associated with a range of congenital and acquired water balance disorders including nephrogenic diabetes insipidus and states of water retention.	Water	156-161	arginine vasopressin	Rattus norvegicus	53-64
9869500-7	1998	In the guinea pig isolated aorta, the relaxation to bradykinin was abolished by long-term in vivo treatment with L-nitro-arginine-methyl-ester (L-NAME; 1.5 mg/ml, in the drinking water for &gt; or =4 days).	Water	179-184	kininogen 1	Canis lupus familiaris	52-62
9893450-6	1998	The presence and distribution of ET-1 in salivary glands and salivary gland tumors suggests a possible role for ET-1 in the regulation of electrolytes and water transport in salivary glands, and as a growth-promoting factor for tumors.	Water	155-160	endothelin 1	Homo sapiens	33-37
9893450-6	1998	The presence and distribution of ET-1 in salivary glands and salivary gland tumors suggests a possible role for ET-1 in the regulation of electrolytes and water transport in salivary glands, and as a growth-promoting factor for tumors.	Water	155-160	endothelin 1	Homo sapiens	112-116
9824541-0	1998	Aquaporins (water channels): role in vasopressin-activated water transport.	Water	12-17	arginine vasopressin	Homo sapiens	37-48
9824541-4	1998	Aquaporin-1 is involved in water reabsorption in the kidney"s proximal tubules and the thin descending Henle"s loop, aqueous humor formation in eye, cerebrospinal fluid formation in brain, and airway hydration in lung.	Water	27-32	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
9824541-5	1998	Aquaporin-2 is the only water channel that is activated by vasopressin to enhance water reabsorption in the kidney collecting duct.	Water	24-29	arginine vasopressin	Homo sapiens	59-70
9877005-4	1998	Following the substitution of caffeine solution for tap water, behavior was temporarily disrupted as evidenced by decreases in responding and QL values which reached a maximum after 72 h (rate 60% and QL 30% below baseline levels).	Water	56-61	nuclear RNA export factor 1	Rattus norvegicus	52-55
9824541-5	1998	Aquaporin-2 is the only water channel that is activated by vasopressin to enhance water reabsorption in the kidney collecting duct.	Water	82-87	arginine vasopressin	Homo sapiens	59-70
9824541-12	1998	The major focus of this review is a discussion of aquaporins in renal epithelia, and particularly the mechanisms associated with vasopressin-mediated water transport involving aquaporin-2 and the signal transduction pathways linked to vasopressin action.	Water	150-155	arginine vasopressin	Homo sapiens	129-140
9834037-5	1998	This CP47 reaction centre, which has a relative molecular mass of 160K, can perform light-mediated energy and electron-transfer reactions but is unable to oxidize water.	Water	163-168	beaded filament structural protein 2	Homo sapiens	5-9
9819374-2	1998	In rats, 24 h water restriction increased mean urinary osmolality (Uosm) from 2, 179+/-153 mOsm/kg to 2,944+/-294 mOsm/kg (P &lt; 0.001) and was associated with significant (P &lt; 0.05) increases in the papillary activity of c-Jun NH2-terminal protein kinase (JNK) by 22%, extracellular signal-regulated protein kinase (ERK) by 49%, and p38 MAPK by 15%.	Water	14-19	Eph receptor B1	Rattus norvegicus	274-319
9806845-7	1998	The expression of human AQP8 cRNA in Xenopus oocytes increased osmotic water permeability by 10-fold.	Water	71-76	aquaporin 8	Homo sapiens	24-28
9844570-1	1998	A method has been developed for determination of (ultra)trace amounts of As(III) and As(V) in water by flow injection on-line sorption preconcentration and separation coupled with inductively coupled plasma mass spectrometry (ICPMS) using a knotted reactor (KR).	Water	94-99	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	85-90
9795050-1	1998	A new method for encapsulating a model protein, lysozyme into hydrophilic uncapped poly(d,l-lactic-co-glycolic acid) (PLGA) microspheres was developed using an oil/water (O/W) single emulsion technique.	Water	164-169	lysozyme	Homo sapiens	48-56
9857473-1	1998	The title compound, C7H8NO3+.Cl-.H2O, crystallized in the centrosymmetric space group P2(1)/c in an ionic form, the proton from HCl having been transferred to the amino N atom.	Water	33-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	86-93
9819374-2	1998	In rats, 24 h water restriction increased mean urinary osmolality (Uosm) from 2, 179+/-153 mOsm/kg to 2,944+/-294 mOsm/kg (P &lt; 0.001) and was associated with significant (P &lt; 0.05) increases in the papillary activity of c-Jun NH2-terminal protein kinase (JNK) by 22%, extracellular signal-regulated protein kinase (ERK) by 49%, and p38 MAPK by 15%.	Water	14-19	Eph receptor B1	Rattus norvegicus	321-324
9819374-3	1998	Conversely, 24 h of water-loading (Uosm 473+/-33 mOsm/kg) caused suppression of JNK activity by 43% (P &lt; 0.001), ERK by 39% (P &lt; 0.05), and p38 MAPK by 26% (P &lt; 0.05).	Water	20-25	Eph receptor B1	Rattus norvegicus	116-119
9815137-1	1998	Cultured renal epithelial cells rapidly downregulate expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2).	Water	93-98	arginine vasopressin	Rattus norvegicus	71-82
9835469-0	1998	Wound irrigation with tap water.	Water	26-31	nuclear RNA export factor 1	Rattus norvegicus	22-25
9835469-1	1998	OBJECTIVE: The study hypothesis was that irrigation with tap water is as efficacious as irrigation with sterile saline in removing bacteria from simple lacerations in preparation for wound closure.	Water	61-66	nuclear RNA export factor 1	Rattus norvegicus	57-60
9835469-9	1998	The wounds irrigated with saline had a mean reduction in bacterial count of 54.7% (SD=+/-28%), while the wounds irrigated with tap water had a mean reduction in bacterial count of 80.6% (SD=+/-20%) (p &lt; 0.05, 2-tailed, paired t-test).	Water	131-136	nuclear RNA export factor 1	Rattus norvegicus	127-130
9835469-12	1998	In certain instances, such as with upper-extremity lacerations, tap water irrigation would likely be cheaper and less labor-intensive than irrigation with normal saline from a syringe.	Water	68-73	nuclear RNA export factor 1	Rattus norvegicus	64-67
9822111-5	1998	Acutely, vasopressin induces exocytic insertion of AQP2 into the apical plasma membrane to increase collecting duct water reabsorption.	Water	116-121	arginine vasopressin	Homo sapiens	9-20
9822112-2	1998	This process predominantly occurs in renal collecting duct cells, where transcellular water reabsorption is induced after binding of the pituitary hormone arginine-vasopressin to its vasopressin type-2 receptor and the subsequent insertion of aquaporin-2 (AQP2) water channels in the apical membrane of these cells.	Water	86-91	arginine vasopressin	Homo sapiens	164-175
9822112-2	1998	This process predominantly occurs in renal collecting duct cells, where transcellular water reabsorption is induced after binding of the pituitary hormone arginine-vasopressin to its vasopressin type-2 receptor and the subsequent insertion of aquaporin-2 (AQP2) water channels in the apical membrane of these cells.	Water	86-91	arginine vasopressin	Homo sapiens	183-194
9822112-2	1998	This process predominantly occurs in renal collecting duct cells, where transcellular water reabsorption is induced after binding of the pituitary hormone arginine-vasopressin to its vasopressin type-2 receptor and the subsequent insertion of aquaporin-2 (AQP2) water channels in the apical membrane of these cells.	Water	262-267	arginine vasopressin	Homo sapiens	164-175
9822112-4	1998	Nephrogenic diabetes insipidus is characterized by the inability of the kidney to concentrate urine in response to vasopressin; the vasopressin type-2 receptor and the AQP2 water channel have both been shown to be involved in this disease.	Water	173-178	arginine vasopressin	Homo sapiens	115-126
9791058-5	1998	Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present.	Water	79-84	angiotensinogen	Rattus norvegicus	64-70
9815132-1	1998	Vesicle targeting proteins ("SNAREs") have been proposed to direct vasopressin-induced trafficking of aquaporin-2 water channels in kidney collecting ducts.	Water	114-119	arginine vasopressin	Rattus norvegicus	67-78
9823712-1	1998	Ion abundances in the MALDI TOF mass spectra of the model peptides (bradykinin, alpha-melanocyte stimulating hormone, and melittin) change significantly as water is added to the solution used for dried droplet sample preparation.	Water	156-161	kininogen 1	Homo sapiens	68-78
9823712-1	1998	Ion abundances in the MALDI TOF mass spectra of the model peptides (bradykinin, alpha-melanocyte stimulating hormone, and melittin) change significantly as water is added to the solution used for dried droplet sample preparation.	Water	156-161	proopiomelanocortin	Homo sapiens	80-130
10193258-4	1998	In two patients, in whom water deprivation tests were equivocal or impractical, an inappropriately low antidiuretic hormone (ADH) concentration (&lt; 1 pmol/l) was demonstrated in the presence of an adequate osmotic stimulus (plasma osmolality &gt; 295 mosmol/kg).	Water	25-30	arginine vasopressin	Homo sapiens	103-123
10193258-4	1998	In two patients, in whom water deprivation tests were equivocal or impractical, an inappropriately low antidiuretic hormone (ADH) concentration (&lt; 1 pmol/l) was demonstrated in the presence of an adequate osmotic stimulus (plasma osmolality &gt; 295 mosmol/kg).	Water	25-30	arginine vasopressin	Homo sapiens	125-128
9873154-0	1998	Vasopressin induces dopamine release and cyclic AMP efflux from the brain of water-deprived rats: inhibitory effect of vasopressin V2 receptor-mediated phosphorylation.	Water	77-82	arginine vasopressin	Rattus norvegicus	0-11
9809195-12	1998	Higher levels of AngII in the bloodstream activate additional neurons in the outer parts of the SFO that connect to the supraoptic, paraventricular and median preoptic nuclei and these probably mediate water drinking and vasopressin secretion induced by blood-borne AngII.	Water	202-207	angiotensinogen	Homo sapiens	17-22
9846621-7	1998	Unexpectedly, the water-insoluble fraction of rat lens contained enzymatically active Lp82.	Water	18-23	calpain 3	Rattus norvegicus	86-90
9878126-8	1998	Expression of mRNAs for IL-1alpha and IL-1beta was observed in the large intestine of mice which received distilled water containing 3% DSS for 5 days.	Water	116-121	interleukin 1 beta	Mus musculus	38-46
9824501-2	1998	The purified MOBP was soluble in water and showed retarded migration on sodium dodecyl sulphate-polyacrylamide gel electrophoresis similar to myelin basic protein (MBP).	Water	33-38	myelin-associated oligodendrocytic basic protein	Mus musculus	13-17
9822113-1	1998	Several aquaporin-type water channels are expressed in mammalian kidney and lung: AQP1 in lung microvessels and kidney proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 in apical membrane of collecting duct epithelium; AQP3 and AQP4 in basolateral membranes of airway and collecting duct epithelium; and AQP5 in alveolar epithelium.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	82-86
9822113-3	1998	In the kidney, water permeability is high in proximal tubule and thin descending limb of Henle, and regulated by vasopressin in collecting duct.	Water	15-20	arginine vasopressin	Homo sapiens	113-124
9822114-1	1998	Traditionally, arginine vasopressin modulation of renal water, sodium, and urea excretion has been considered somewhat in isolation from factors that control divalent mineral ion homeostasis.	Water	56-61	arginine vasopressin	Homo sapiens	24-35
9831428-4	1998	In &lt;10% of the families studied, congenital NDI has an autosomal recessive inheritance and mutations of the aquaporin-2 gene (AQP2), ie, the vasopressin-sensitive water channel, have been identified.	Water	166-171	arginine vasopressin receptor 2	Homo sapiens	47-50
9831428-4	1998	In &lt;10% of the families studied, congenital NDI has an autosomal recessive inheritance and mutations of the aquaporin-2 gene (AQP2), ie, the vasopressin-sensitive water channel, have been identified.	Water	166-171	arginine vasopressin	Homo sapiens	144-155
9868963-1	1998	We treated two cases of diabetes mellitus who developed acute pulmonary edema following accidental aspiration of sweetened water for emergency treatment, when they had fallen into hypoglycemic coma following an overdose of injectable insulin.	Water	123-128	insulin	Homo sapiens	234-241
9799680-1	1998	Two pulse sequences are described that employ a modified water flipback technique to enhance the signal intensity of weak side chain resonances at the protein-DNA interface of the vnd/NK-2 homeodomain/DNA complex in an 15N-edited three-dimensional NOESY-HMQC spectrum.	Water	57-62	NK2 homeobox 1	Homo sapiens	184-188
9814488-5	1998	In the control group, minimal urinary osmolality was as low as 131 mosmol/kg H2O, which was responsible for the decrease in plasma arginine vasopressin (AVP) levels after the reduction in plasma osmolality.	Water	77-80	arginine vasopressin	Homo sapiens	140-151
9799702-1	1998	The magnetic coupling between methyl lactate protons and water protons in samples of cross-linked bovine serum albumin (BSA) is studied.	Water	57-62	albumin	Homo sapiens	105-118
9826210-1	1998	Aquaporin-2 (AQP-2) encodes the vasopressin-regulated "water channels" of the renal collecting duct and is excreted in human urine.	Water	55-60	arginine vasopressin	Homo sapiens	32-43
9799415-1	1998	The anti-diuretic hormone vasopressin (AVP) regulates water excretion from the kidney by increasing the water permeability of the collecting duct.	Water	54-59	arginine vasopressin	Homo sapiens	4-37
10068041-4	1998	Inspection of the structure of the complex suggested that it might be possible to convert the scFv into a bond-specific protease by the introduction of three catalytic residues: a glutamate to increase the nucleophilicity of a nearby water molecule, a lysine to increase the polarizability of the carbonyl group and a histidine to provide a proton to convert the amine into a better leaving group.	Water	234-239	immunglobulin heavy chain variable region	Homo sapiens	94-98
9799415-1	1998	The anti-diuretic hormone vasopressin (AVP) regulates water excretion from the kidney by increasing the water permeability of the collecting duct.	Water	54-59	arginine vasopressin	Homo sapiens	39-42
9799415-1	1998	The anti-diuretic hormone vasopressin (AVP) regulates water excretion from the kidney by increasing the water permeability of the collecting duct.	Water	104-109	arginine vasopressin	Homo sapiens	4-37
9799415-1	1998	The anti-diuretic hormone vasopressin (AVP) regulates water excretion from the kidney by increasing the water permeability of the collecting duct.	Water	104-109	arginine vasopressin	Homo sapiens	39-42
9799415-3	1998	By this mechanism AVP controls water reabsorption in the kidney.	Water	31-36	arginine vasopressin	Homo sapiens	18-21
10518920-10	1998	cm-2.min-1/degree C. The results of this study clearly demonstrated the temperature-dependency of flux rates of water across vaginal mucosa, and this should be taken into account whenever the in vitro vaginal/buccal model is used at room temperature for predicting in vivo buccal drug absorption kinetics.	Water	112-117	CD59 molecule (CD59 blood group)	Homo sapiens	5-10
9834976-5	1998	In low output heart failure non-peptide selective orally active vasopressin V2-receptor antagonists correct the hyponatremia, hypoosmolality, and water retention and decrease urinary aquaporin-2 water channels, supporting the role of vasopressin in the water retention seen in heart failure.	Water	146-151	arginine vasopressin receptor 2	Homo sapiens	64-87
9834976-5	1998	In low output heart failure non-peptide selective orally active vasopressin V2-receptor antagonists correct the hyponatremia, hypoosmolality, and water retention and decrease urinary aquaporin-2 water channels, supporting the role of vasopressin in the water retention seen in heart failure.	Water	146-151	arginine vasopressin	Homo sapiens	64-75
9834976-5	1998	In low output heart failure non-peptide selective orally active vasopressin V2-receptor antagonists correct the hyponatremia, hypoosmolality, and water retention and decrease urinary aquaporin-2 water channels, supporting the role of vasopressin in the water retention seen in heart failure.	Water	195-200	arginine vasopressin receptor 2	Homo sapiens	64-87
9834976-5	1998	In low output heart failure non-peptide selective orally active vasopressin V2-receptor antagonists correct the hyponatremia, hypoosmolality, and water retention and decrease urinary aquaporin-2 water channels, supporting the role of vasopressin in the water retention seen in heart failure.	Water	195-200	arginine vasopressin	Homo sapiens	64-75
9834976-5	1998	In low output heart failure non-peptide selective orally active vasopressin V2-receptor antagonists correct the hyponatremia, hypoosmolality, and water retention and decrease urinary aquaporin-2 water channels, supporting the role of vasopressin in the water retention seen in heart failure.	Water	195-200	arginine vasopressin receptor 2	Homo sapiens	64-87
9834976-5	1998	In low output heart failure non-peptide selective orally active vasopressin V2-receptor antagonists correct the hyponatremia, hypoosmolality, and water retention and decrease urinary aquaporin-2 water channels, supporting the role of vasopressin in the water retention seen in heart failure.	Water	195-200	arginine vasopressin	Homo sapiens	64-75
9788998-1	1998	Cytochrome c oxidase catalyzes the reduction of oxygen to water that is accompanied by pumping of four protons across the mitochondrial or bacterial membrane.	Water	58-63	cytochrome c, somatic	Homo sapiens	0-12
9818392-1	1998	Octadecyl (C18)-bonded porous silica was evaluated for the extraction of triazines, organochlorine, carbamates and acidic pesticides from surface and ground water.	Water	157-162	Bardet-Biedl syndrome 9	Homo sapiens	11-14
9818399-5	1998	Using the C18 pre-column, up to 50 ml of water sample could be percolated without peak broadening of any compound.	Water	41-46	Bardet-Biedl syndrome 9	Homo sapiens	10-13
9715667-5	1998	However, calorimetric measurements provide data revealing only the two-state mechanism of alpha-lactalbumin unfolding in both water and in aqueous ethanol solutions.	Water	126-131	lactalbumin alpha	Homo sapiens	90-107
26735121-6	1998	Co-treatment with yohimbine dissolved in the tap water (70 mg/l) decreased the number of jumps upon naloxone challenge, an effect which did not seem to be related with a sedative or toxic effect of the drug.	Water	49-54	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	45-48
9790367-1	1998	OBJECTIVE: Fetal arginine vasopressin contributes to fetal and amniotic fluid homeostasis by increasing water resorption in the kidney and, at higher plasma levels, circulatory homeostasis by vasopressor effects.	Water	104-109	arginine vasopressin	Rattus norvegicus	26-37
9755064-1	1998	Acute hypotonic shock (50% dilution of medium with sterile water, but not with isotonic NaCl) activated the extracellular signal response kinase (ERK) mitogen-activated protein (MAP) kinases in renal medullary cells, as measured by Western analysis with a phospho-ERK-specific antibody and by in vitro kinase assay of epitope-tagged ERKs immunoprecipitated from stable HA-ERK transfectants.	Water	59-64	mitogen-activated protein kinase 1	Homo sapiens	108-144
9755064-1	1998	Acute hypotonic shock (50% dilution of medium with sterile water, but not with isotonic NaCl) activated the extracellular signal response kinase (ERK) mitogen-activated protein (MAP) kinases in renal medullary cells, as measured by Western analysis with a phospho-ERK-specific antibody and by in vitro kinase assay of epitope-tagged ERKs immunoprecipitated from stable HA-ERK transfectants.	Water	59-64	mitogen-activated protein kinase 1	Homo sapiens	146-149
10412431-5	1998	Assuming that water is the only species transported under these conditions, a water transport model of the form dV/dT = f(Lpg([CPA]), ELp([CPA]), T(t)) was curve-fit to the experimental data to obtain the biophysical parameters of water transport--the reference hydraulic permeability (Lpg) and activation energy of water transport (ELp)--for each DMSO concentration.	Water	78-83	lens epithelial protein	Rattus norvegicus	333-336
9856589-3	1998	The bFGF sorption was almost independent of the sorption temperature except for 4 degrees C and the hydrogel water content.	Water	109-114	fibroblast growth factor 2	Homo sapiens	4-8
9792413-9	1998	CDD/ANP-1-126, cleaved from a precursor of 126 amino acids in the heart to a 28-amino acid-containing circulating molecular form (CDD/ANP-99-126), and urodilatin (CDD/ANP-95-126) share similar biochemical features and biological functions, but urodilatin may be more involved in the regulation of body fluid volume and water-electrolyte excretion, while circulating CDD/ANP-99-126 is responsible for blood pressure regulation.	Water	319-324	natriuretic peptide A	Homo sapiens	0-3
9792416-1	1998	Aquaporin 2 (AQP2) transfected into LLC-PK1 cells functions as a vasopressin-regulated water channel that recycles between intracellular vesicles and the plasma membrane upon vasopressin stimulation.	Water	87-92	vasopressin	Sus scrofa	65-76
9792416-1	1998	Aquaporin 2 (AQP2) transfected into LLC-PK1 cells functions as a vasopressin-regulated water channel that recycles between intracellular vesicles and the plasma membrane upon vasopressin stimulation.	Water	87-92	vasopressin	Sus scrofa	175-186
10412431-5	1998	Assuming that water is the only species transported under these conditions, a water transport model of the form dV/dT = f(Lpg([CPA]), ELp([CPA]), T(t)) was curve-fit to the experimental data to obtain the biophysical parameters of water transport--the reference hydraulic permeability (Lpg) and activation energy of water transport (ELp)--for each DMSO concentration.	Water	78-83	lens epithelial protein	Rattus norvegicus	333-336
10412431-5	1998	Assuming that water is the only species transported under these conditions, a water transport model of the form dV/dT = f(Lpg([CPA]), ELp([CPA]), T(t)) was curve-fit to the experimental data to obtain the biophysical parameters of water transport--the reference hydraulic permeability (Lpg) and activation energy of water transport (ELp)--for each DMSO concentration.	Water	78-83	lens epithelial protein	Rattus norvegicus	333-336
10412432-9	1998	The biophysical parameters of water transport for rat liver tissue at 5 degrees C/min were obtained as Lpg = 3.16 x 10(-13) m3/Ns (1.9 microns/min-atm), ELp = 265 kJ/mole (63.4 kcal/mole), respectively.	Water	30-35	lens epithelial protein	Rattus norvegicus	153-156
9845004-1	1998	Prolactin (PRL) has been reported to promote antidiuresis and increase intestinal water-electrolyte absorption, whereas osmolar changes have been shown to influence PRL secretion.	Water	82-87	prolactin	Homo sapiens	0-9
9767520-1	1998	Since 1992 and the discovery of an MIP (major intrinsic protein of lens fiber cell) homologue protein that selectively permeates water, aquaporin (AQP), there has been an explosion of research in this field.	Water	129-134	major intrinsic protein of lens fiber	Homo sapiens	35-38
9767520-4	1998	To date 10 aquaporins have been discovered and a plethora of MIP members, and their prevalance in almost all organisms is a testament to their indispensible roles in the body, possibly as water and small neutral solute transporting channels.	Water	188-193	major intrinsic protein of lens fiber	Homo sapiens	61-64
9761646-1	1998	We have studied the adsorption of lysozyme layers at a hydrophobic silicon water interface using specular neutron reflection.	Water	75-80	lysozyme	Homo sapiens	34-42
9845004-1	1998	Prolactin (PRL) has been reported to promote antidiuresis and increase intestinal water-electrolyte absorption, whereas osmolar changes have been shown to influence PRL secretion.	Water	82-87	prolactin	Homo sapiens	11-14
9845004-5	1998	In healthy women (21-39 y, n=6), an oral water load (OWL, 20 ml/bw) significantly suppressed the plasma levels of AVP, OXT and cortisol, and the PRL level too tended to decrease.	Water	41-46	prolactin	Homo sapiens	145-148
9845004-6	1998	In hyperprolactinaemic females (22-41 y, n=6, three with pituitary adenomas), water retention was registered following an OWL, together with paradoxical AVP and OXT level increases, whereas the cortisol response remained normal, and the PRL level did not change at all.	Water	78-83	prolactin	Homo sapiens	237-240
9733774-3	1998	Here we report the expression cloning of a liver cDNA encoding a unique promiscuous solute channel (AQP9) that confers high permeability for both solutes and water.	Water	158-163	aquaporin 9	Homo sapiens	100-104
11670645-1	1998	Synthesis and Structures of Amino-Containing Cyclopentadienyl Derivatives of Cobalt(I) and -(III) Including Water-Soluble Compounds.	Water	108-113	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	93-96
9733774-5	1998	The properties of AQP9 define a new evolutionary branch of the major intrinsic protein family of aquaporin proteins and describe a previously unknown mechanism by which a large variety of solutes and water can pass through a single pore, enabling rapid cellular uptake or exit of metabolites with minimal osmotic perturbation.	Water	200-205	aquaporin 9	Homo sapiens	18-22
9735295-14	1998	(3) Three well-ordered water molecules in hydrogen bond distance to side-chains of the catalytic triad may be significant for the proton release steps in DADH catalysis.A ternary structure-based sequence alignment with ten members of the SDR family with known three-dimensional structure has suggested to define a model consisting of four groups of residues, which relates the observed low degree of sequence identity to quite similar folding patterns and nearly identical distributions of residues involved in catalysis.	Water	23-28	Alcohol dehydrogenase	Drosophila melanogaster	154-158
9801832-2	1998	The crystal structure reveals that both the amide carbonyl oxygen and the terminal amino nitrogen of Gly-Tyr coordinate to the active site zinc ion of CPA in a bidentate fashion, whereby the zinc-bound water molecule is displaced by the amino group.	Water	202-207	carboxypeptidase A1	Homo sapiens	151-154
9735207-7	1998	Globule-like macroions such as LZ and BSA show high surface activity at isoelectric point above m* accompanied with orientation of the molecules along the air-water interface.	Water	159-164	lysozyme	Homo sapiens	31-33
9753693-5	1998	RESULTS: Here we use a combination of nanoflow electrospray ionization mass spectrometry (ESI-MS), isothermal titration calorimetry and structural data to investigate the effect of water molecules in complexes formed between the SH2 domain of tyrosine kinase Src and tyrosyl phosphopeptides.	Water	181-186	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	259-262
9748556-8	1998	This unique spectral feature was therefore analyzed to show that the myoglobin is in equilibrium between two species, depending upon the presence or absence of a water molecule at the sixth coordinate position.	Water	162-167	myoglobin	Loxodonta africana	69-78
9801832-3	1998	As to the catalytic mechanism of CPA, it is generally believed that while in the cases of ester substrates the carboxylate of Glu-270 functions as the nucleophile which attacks the scissile carbonyl carbon (anhydride pathway), in the case of peptide substrates the zinc-bound water molecule attacks the scissile peptide bond (general base pathway).	Water	276-281	carboxypeptidase A1	Homo sapiens	33-36
9745408-9	1998	Abnormalities in arginine vasopressin responses to water deprivation or hypertonic saline infusion were seen only in four patients who had preexisting diabetes insipidus (DI); one patient who later developed DI had normal findings.	Water	51-56	arginine vasopressin	Homo sapiens	26-37
9789303-3	1998	Recent basic experimental data show the most possible mechanism for the transport of peripheral AVP across the BBB is binding of V1 receptor of AVP at the capillary luminal membrane and consequently transports AVP to neuronal cell and changes in permeability of amino acid, ion and water at the BBB.	Water	282-287	arginine vasopressin	Homo sapiens	96-99
9855025-2	1998	Because angiotensin II affects blood pressure control, sodium and water homeostasis, and cardiovascular function and structure, a great deal of research effort has been directed toward blocking the renin-angiotensin system.	Water	66-71	angiotensinogen	Homo sapiens	8-22
9741688-0	1998	The hydrophobic surface of colipase influences lipase activity at an oil-water interface.	Water	73-78	colipase	Homo sapiens	27-35
9741688-1	1998	The interaction of pancreatic triglyceride lipase and colipase at an oil-water interface is required for efficient digestion of dietary fats and provides a model system for the interaction of proteins at biological membranes.	Water	73-78	colipase	Homo sapiens	54-62
9736261-5	1998	EP3 receptor activation inhibits cAMP generation via Gi, thus inhibiting vasopressin-stimulated water reabsorption in the CD.	Water	96-101	prostaglandin E receptor 3	Homo sapiens	0-3
9736267-4	1998	V2 AVP receptor antagonists correct the impaired water excretion in rats with low-output CF, increase solute free water clearance, correct the hyponatremia in congestive CF patients, and normalize urinary concentrations of the aquaporin-2 (AQP-2) water channels.	Water	49-54	arginine vasopressin	Rattus norvegicus	3-6
9736267-4	1998	V2 AVP receptor antagonists correct the impaired water excretion in rats with low-output CF, increase solute free water clearance, correct the hyponatremia in congestive CF patients, and normalize urinary concentrations of the aquaporin-2 (AQP-2) water channels.	Water	114-119	arginine vasopressin	Rattus norvegicus	3-6
9736267-11	1998	In summary, AVP-mediated water retention through collecting duct AQP-2 water channels is important in both low-output CF and high-output states such as cirrhosis and pregnancy.	Water	25-30	arginine vasopressin	Rattus norvegicus	12-15
9789303-3	1998	Recent basic experimental data show the most possible mechanism for the transport of peripheral AVP across the BBB is binding of V1 receptor of AVP at the capillary luminal membrane and consequently transports AVP to neuronal cell and changes in permeability of amino acid, ion and water at the BBB.	Water	282-287	arginine vasopressin	Homo sapiens	144-147
9789303-3	1998	Recent basic experimental data show the most possible mechanism for the transport of peripheral AVP across the BBB is binding of V1 receptor of AVP at the capillary luminal membrane and consequently transports AVP to neuronal cell and changes in permeability of amino acid, ion and water at the BBB.	Water	282-287	arginine vasopressin	Homo sapiens	144-147
9789303-4	1998	An increase in peripheral AVP results in suppression of amino acid permeability and increases in transport of sodium, potassium ions and water.	Water	137-142	arginine vasopressin	Homo sapiens	26-29
9756089-2	1998	Aquaporin-2 is the vasopressin-responsive water channel in the collecting duct, and vasopressin control of water permeability in the collecting duct occurs in two ways: a short-term regulation and a long-term adaptation.	Water	107-112	arginine vasopressin	Homo sapiens	84-95
9714073-1	1998	Pretreatment and removal of vasopressin (ADH) in toad urinary bladder renal model tissues induces endocytosis at 25 degrees C. The objective of the current study is to determine if apical membrane remodeling, as well as transepithelial water flow, can be affected by lowering the temperature to 15 degrees C. Control toad urinary bladders in the presence of an osmotic gradient at either 25 degrees C or 15 degrees C when visualized by scanning electron microscopy (SEM) show a typical apical membrane surface with no apparent surface differences.	Water	236-241	arginine vasopressin	Homo sapiens	28-39
9756088-2	1998	This is a rare, but now well described entity secondary to either mutations in the AVPR2 gene that codes for the vasopressin antidiuretic (V2) receptor or to mutations in the AQP2 gene that codes for the vasopressin-dependent water channel.	Water	226-231	arginine vasopressin receptor 2	Homo sapiens	83-88
9756089-2	1998	Aquaporin-2 is the vasopressin-responsive water channel in the collecting duct, and vasopressin control of water permeability in the collecting duct occurs in two ways: a short-term regulation and a long-term adaptation.	Water	42-47	arginine vasopressin	Homo sapiens	19-30
9756090-1	1998	A series of recent studies have demonstrated that expression of aquaporin-2 (AQP2), the vasopressin-regulated water channel of the kidney collecting duct, is greatly reduced in acquired forms of nephrogenic diabetes insipidus (NDI).	Water	110-115	arginine vasopressin	Homo sapiens	88-99
9712891-1	1998	Vasopressin is the key regulator of water homeostasis in vertebrates.	Water	36-41	arginine vasopressin	Rattus norvegicus	0-11
9712891-5	1998	Treatment of CD8 cells with pertussis toxin (PTX) inhibited both the vasopressin-induced increase in water permeability and the redistribution of AQP2 from an intracellular compartment to the apical membrane.	Water	101-106	arginine vasopressin	Rattus norvegicus	69-80
9679185-2	1998	The hypothesis was tested that in hydrated humans the release of arginine vasopressin and angiotensin II is suppressed by water immersion (WI) and that this is a mechanism of the immersion-induced diuresis and natriuresis.	Water	122-127	arginine vasopressin	Homo sapiens	74-85
18286054-1	1998	We measure the second- and third-order dispersion coefficients, d(2)k/domega(2) and d(3)k/domega(3), of water for wavelengths from 0.45 to 1.3 mum using a Michelson white-light interferometer.	Water	104-109	latexin	Homo sapiens	143-146
18286054-3	1998	We observe an oscillation in d(2)k/domega(2) near 1.1 mum that is due to water absorption features near that wavelength.	Water	73-78	latexin	Homo sapiens	54-57
9679185-2	1998	The hypothesis was tested that in hydrated humans the release of arginine vasopressin and angiotensin II is suppressed by water immersion (WI) and that this is a mechanism of the immersion-induced diuresis and natriuresis.	Water	122-127	angiotensinogen	Homo sapiens	90-104
9692992-1	1998	Phospholipid hydrolysis to free fatty acid and 1-lyso-phospholipid by water-soluble phospholipase A2 (PLA2) at the surface of lipid membranes exhibits a poorly understood transition from a low-activity lag phase to a burst regime of rapid hydrolysis.	Water	70-75	phospholipase A2 group IB	Homo sapiens	84-100
9766251-1	1998	Insulin (Ins) spontaneously and easily complexed with the hydrogel nanoparticle of hydrophobized cholesterol-bearing pullulan (CHP) in water.	Water	135-140	insulin	Homo sapiens	0-7
9729254-3	1998	The intake of 0.3 M NaCl and water was induced by combined administration of the diuretic, furosemide (FURO), and the angiotensin-converting enzyme inhibitor, captopril (CAP).	Water	29-34	angiotensin I converting enzyme	Homo sapiens	118-147
9692992-1	1998	Phospholipid hydrolysis to free fatty acid and 1-lyso-phospholipid by water-soluble phospholipase A2 (PLA2) at the surface of lipid membranes exhibits a poorly understood transition from a low-activity lag phase to a burst regime of rapid hydrolysis.	Water	70-75	phospholipase A2 group IB	Homo sapiens	102-106
9721005-7	1998	Following repeated immersions in water at 15 degrees C, the fR, VI and fH responses of the H group over the first 30 s of immersion were reduced (P &lt; 0.01) from 33.3 breaths x min(-1), 50.5 l x min(-1) and 114 beats x min(-1) respectively, to 19.8 breaths x min(-1) 26.41 x min(-1) and 98 beats x min(-1), respectively.	Water	33-38	CD59 molecule (CD59 blood group)	Homo sapiens	179-185
9721005-8	1998	In water at 10 degrees C these responses were reduced (P &lt; 0.01) from 47.3 breaths x min(-1), 67.61 x min(-1) and 128 beats x min(-1) to 24.0 breaths x min(-1), 29.5 l x min(-1) and 109 beats x min(-1), respectively over a corresponding period of immersion.	Water	3-8	CD59 molecule (CD59 blood group)	Homo sapiens	105-111
9688688-13	1998	The data demonstrate that ANG II mediates jejunal sodium and water absorption by an action at the AT2 receptor involving cGMP formation.	Water	61-66	angiotensinogen	Rattus norvegicus	26-32
9721005-8	1998	In water at 10 degrees C these responses were reduced (P &lt; 0.01) from 47.3 breaths x min(-1), 67.61 x min(-1) and 128 beats x min(-1) to 24.0 breaths x min(-1), 29.5 l x min(-1) and 109 beats x min(-1), respectively over a corresponding period of immersion.	Water	3-8	CD59 molecule (CD59 blood group)	Homo sapiens	105-111
9721005-7	1998	Following repeated immersions in water at 15 degrees C, the fR, VI and fH responses of the H group over the first 30 s of immersion were reduced (P &lt; 0.01) from 33.3 breaths x min(-1), 50.5 l x min(-1) and 114 beats x min(-1) respectively, to 19.8 breaths x min(-1) 26.41 x min(-1) and 98 beats x min(-1), respectively.	Water	33-38	CD59 molecule (CD59 blood group)	Homo sapiens	197-203
9721005-8	1998	In water at 10 degrees C these responses were reduced (P &lt; 0.01) from 47.3 breaths x min(-1), 67.61 x min(-1) and 128 beats x min(-1) to 24.0 breaths x min(-1), 29.5 l x min(-1) and 109 beats x min(-1), respectively over a corresponding period of immersion.	Water	3-8	CD59 molecule (CD59 blood group)	Homo sapiens	105-111
9721005-8	1998	In water at 10 degrees C these responses were reduced (P &lt; 0.01) from 47.3 breaths x min(-1), 67.61 x min(-1) and 128 beats x min(-1) to 24.0 breaths x min(-1), 29.5 l x min(-1) and 109 beats x min(-1), respectively over a corresponding period of immersion.	Water	3-8	CD59 molecule (CD59 blood group)	Homo sapiens	105-111
9721005-8	1998	In water at 10 degrees C these responses were reduced (P &lt; 0.01) from 47.3 breaths x min(-1), 67.61 x min(-1) and 128 beats x min(-1) to 24.0 breaths x min(-1), 29.5 l x min(-1) and 109 beats x min(-1), respectively over a corresponding period of immersion.	Water	3-8	CD59 molecule (CD59 blood group)	Homo sapiens	105-111
9721005-7	1998	Following repeated immersions in water at 15 degrees C, the fR, VI and fH responses of the H group over the first 30 s of immersion were reduced (P &lt; 0.01) from 33.3 breaths x min(-1), 50.5 l x min(-1) and 114 beats x min(-1) respectively, to 19.8 breaths x min(-1) 26.41 x min(-1) and 98 beats x min(-1), respectively.	Water	33-38	CD59 molecule (CD59 blood group)	Homo sapiens	197-203
9721005-7	1998	Following repeated immersions in water at 15 degrees C, the fR, VI and fH responses of the H group over the first 30 s of immersion were reduced (P &lt; 0.01) from 33.3 breaths x min(-1), 50.5 l x min(-1) and 114 beats x min(-1) respectively, to 19.8 breaths x min(-1) 26.41 x min(-1) and 98 beats x min(-1), respectively.	Water	33-38	CD59 molecule (CD59 blood group)	Homo sapiens	197-203
9721005-7	1998	Following repeated immersions in water at 15 degrees C, the fR, VI and fH responses of the H group over the first 30 s of immersion were reduced (P &lt; 0.01) from 33.3 breaths x min(-1), 50.5 l x min(-1) and 114 beats x min(-1) respectively, to 19.8 breaths x min(-1) 26.41 x min(-1) and 98 beats x min(-1), respectively.	Water	33-38	CD59 molecule (CD59 blood group)	Homo sapiens	197-203
9721005-7	1998	Following repeated immersions in water at 15 degrees C, the fR, VI and fH responses of the H group over the first 30 s of immersion were reduced (P &lt; 0.01) from 33.3 breaths x min(-1), 50.5 l x min(-1) and 114 beats x min(-1) respectively, to 19.8 breaths x min(-1) 26.41 x min(-1) and 98 beats x min(-1), respectively.	Water	33-38	CD59 molecule (CD59 blood group)	Homo sapiens	197-203
9721005-8	1998	In water at 10 degrees C these responses were reduced (P &lt; 0.01) from 47.3 breaths x min(-1), 67.61 x min(-1) and 128 beats x min(-1) to 24.0 breaths x min(-1), 29.5 l x min(-1) and 109 beats x min(-1), respectively over a corresponding period of immersion.	Water	3-8	CD59 molecule (CD59 blood group)	Homo sapiens	88-94
9730169-1	1998	We present a molecular dynamics simulation of xylitol in SPC/E water using classical Gibbs ensemble molecular dynamics simulation.	Water	63-68	proline rich protein gene cluster	Homo sapiens	57-60
9693274-4	1998	We have successfully shown that ryegrass pollen ruptures upon contact with water, releasing about 700 starch granules which not only contain the major allergen Lol p 5, but have been shown to trigger both in vitro and in vivo IgE-mediated responses.	Water	75-80	immunoglobulin heavy constant epsilon	Homo sapiens	226-229
9788291-10	1998	The water-soluble forskolin analogue L-858051, 7-deacetyl-7beta-(gamma-N-methylpiperazino)-butyryl forskolin, significantly inhibited ET-1-stimulated IPs accumulation.	Water	4-9	endothelin 1	Canis lupus familiaris	134-138
9845315-1	1998	This work investigates the noise properties of O-15 water PET images in an attempt to increase the sensitivity of activation studies.	Water	52-57	immunoglobulin kappa variable 2-36 (pseudogene)	Homo sapiens	47-51
9845315-4	1998	Saturation occurs at an activity concentration of 2.2 mCi/l which corresponds to a 75-mCi O-15 water injection into a normal person of average weight.	Water	95-100	immunoglobulin kappa variable 2-36 (pseudogene)	Homo sapiens	90-94
9794709-3	1998	In addition to its direct vascular effects, endothelin-1 has inotropic and mitogenic properties, influences homeostasis of salt and water, alters central and peripheral sympathetic activity and stimulates the renin-angiotensin-aldosterone system.	Water	132-137	endothelin 1	Homo sapiens	44-56
9745898-6	1998	31P NMR experiments clearly indicated that N-terminal domain of statherin exists mainly in disordered state in water whereas, upon addition of structure stabilizing co-solvent, 2,2,2-trifluorethanol (TFE), it showed a strong propensity for helical conformation.	Water	111-116	statherin	Homo sapiens	64-73
9739568-0	1998	Interaction of human serum albumin with dipalmitoylphosphatidylcholine in spread monolayers at the air/water interface (short communication).	Water	103-108	albumin	Homo sapiens	27-34
10082366-10	1998	The structural similarity of the active sites of BS-RNase and RNase A includes some specific water molecules believed to be relevant to catalytic activity.	Water	93-98	ribonuclease pancreatic	Bos taurus	62-69
9764813-1	1998	The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is characterized by hyponatraemia due to water retention resulting from the persistent release of antidiuretic hormone (vasopressin).	Water	113-118	arginine vasopressin	Homo sapiens	43-63
9764813-1	1998	The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is characterized by hyponatraemia due to water retention resulting from the persistent release of antidiuretic hormone (vasopressin).	Water	113-118	arginine vasopressin	Homo sapiens	192-203
9705577-13	1998	In comparison, control and DOCA-treated rats drinking water showed lower levels of AVP mRNA.	Water	54-59	arginine vasopressin	Rattus norvegicus	83-86
9705577-16	1998	In rats offered salt solution and water to drink, DOCA effects on AVP mRNA developed before changes occurred in serum sodium levels.	Water	34-39	arginine vasopressin	Rattus norvegicus	66-69
9692974-3	1998	CA VII has steady-state constants similar to two of the most active isozymes of carbonic anhydrase, CA II and IV; also, it is very strongly inhibited by the sulfonamides ethoxzolamide and acetazolamide, yielding the lowest Ki values measured by the exchange of 18O between CO2 and water for any of the mammalian isozymes of carbonic anhydrase.	Water	281-286	carbonic anhydrase 7	Homo sapiens	0-6
18967255-6	1998	On the other hand, the low stabilization of OH(-) in the mixed solvents relative to that in water and the electrostatic effect are the main factors in determining the solvent effect on pK(b).	Water	92-97	AKT serine/threonine kinase 1	Homo sapiens	185-190
9714539-2	1998	Here we report on the immobilisation of a fusion protein between plant cytochrome P450-71B1 (CYP71B1) and its electron donor, plant NADPH cytochrome P450 reductase using an oil-in-water macro-emulsion, termed polyaphron, which contains a proportion of internal organic phase (phi) greater than 0.74.	Water	180-185	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	71-86
9668062-0	1998	O-glycosylated MUC2 monomer and dimer from LS 174T cells are water-soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds.	Water	61-66	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	15-19
9714539-2	1998	Here we report on the immobilisation of a fusion protein between plant cytochrome P450-71B1 (CYP71B1) and its electron donor, plant NADPH cytochrome P450 reductase using an oil-in-water macro-emulsion, termed polyaphron, which contains a proportion of internal organic phase (phi) greater than 0.74.	Water	180-185	cytochrome p450 oxidoreductase	Homo sapiens	132-163
9657677-9	1998	N-TIMP-1 binding causes the amide of Tyr223 of MMP-3(DeltaC) bound by N-TIMP-1 to exchange with water rapidly, implying a lack of the hydrogen bond observed in the crystal structure.	Water	96-101	TIMP metallopeptidase inhibitor 1	Homo sapiens	0-8
9657677-9	1998	N-TIMP-1 binding causes the amide of Tyr223 of MMP-3(DeltaC) bound by N-TIMP-1 to exchange with water rapidly, implying a lack of the hydrogen bond observed in the crystal structure.	Water	96-101	matrix metallopeptidase 3	Homo sapiens	47-52
9672456-6	1998	There was a mean reduction in bacterial counts of 81.6% with saline and 65.3% with tap water (P = .34).	Water	87-92	nuclear RNA export factor 1	Rattus norvegicus	83-86
9672456-7	1998	One tap water specimen had markedly aberrant bacterial counts compared with others.	Water	8-13	nuclear RNA export factor 1	Rattus norvegicus	4-7
9672456-8	1998	Excluding this specimen, the mean reduction for tap water was 80.2%.	Water	52-57	nuclear RNA export factor 1	Rattus norvegicus	48-51
9689012-1	1998	In the rat cortical collecting duct (CCD), epinephrine inhibits vasopressin (AVP)-dependent water permeability and Na+ reabsorption.	Water	92-97	arginine vasopressin	Rattus norvegicus	64-75
9647215-2	1998	However, in IFN-gamma-deficient mice, EAU develops in the context of an effector response having Th2-like elements, and administration of IL-12 to mice immunized for EAU induction can be protective.	Water	38-41	interferon gamma	Mus musculus	12-21
9720886-6	1998	Covalent immobilization of bovine serum albumin (BSA), gamma-globulin (gamma-Gl) and alkaline phosphatase (APh) was achieved by coupling with a water soluble carbodiimide.	Water	144-149	albumin	Homo sapiens	34-47
9662488-0	1998	Renal haemodynamics, sodium and water reabsorption during continuous intravenous infusion of recombinant interleukin-2.	Water	32-37	interleukin 2	Homo sapiens	105-118
9674641-1	1998	Angiotensin II exerts its effects on cardiovascular function and water and sodium homeostasis by interacting with plasma membrane receptors on target organs.	Water	65-70	angiotensinogen	Rattus norvegicus	0-14
9688911-1	1998	The hormone arginine vasopressin (AVP) contributes to water retention and vasoconstriction in congestive heart failure (CHF) through effects at the V2 and V1a receptors, respectively.	Water	54-59	arginine vasopressin	Rattus norvegicus	34-37
9688911-10	1998	These results suggest that AVP plays a major role in water retention through the renal V2R in a rat model of CHF.	Water	53-58	arginine vasopressin	Rattus norvegicus	27-30
9717743-0	1998	Effect of Na+ and K+ ions on the initial crystallization process of lysozyme in the presence of D2O and H2O.	Water	104-107	lysozyme	Homo sapiens	68-76
9720310-6	1998	UV and O2 consumption measurements showed that the reaction of Co with water consumed molecular oxygen and generated Co(II).	Water	71-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
9717743-4	1998	The initial aggregation rate of lysozyme in H2O was slower than in D2O.	Water	44-47	lysozyme	Homo sapiens	32-40
9717743-2	1998	In the present studies, we examined the initial aggregation process of lysozyme (initial crystallization process of lysozyme) in D2O/H2O with sodium ions or potassium ions, and investigated the relationship between the surface hydrophobicity and the aggregation rate of lysozyme.	Water	133-136	lysozyme	Homo sapiens	71-79
9717743-7	1998	These results suggest that the interaction between lysozyme molecules is stronger in D2O than in H2O.	Water	97-100	lysozyme	Homo sapiens	51-59
9717743-2	1998	In the present studies, we examined the initial aggregation process of lysozyme (initial crystallization process of lysozyme) in D2O/H2O with sodium ions or potassium ions, and investigated the relationship between the surface hydrophobicity and the aggregation rate of lysozyme.	Water	133-136	lysozyme	Homo sapiens	116-124
9717743-2	1998	In the present studies, we examined the initial aggregation process of lysozyme (initial crystallization process of lysozyme) in D2O/H2O with sodium ions or potassium ions, and investigated the relationship between the surface hydrophobicity and the aggregation rate of lysozyme.	Water	133-136	lysozyme	Homo sapiens	116-124
9683734-4	1998	AQP0 with loop E of AQP2 was not impaired in its routing and revealed a low water permeability equal to that of wild-type AQP0.	Water	76-81	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	0-4
9723198-2	1998	The control group received solid diet (Purina rat chow) and tap water ad libitum.	Water	64-69	nuclear RNA export factor 1	Rattus norvegicus	60-63
9648077-0	1998	Low Na+ diet inhibits Na+ and water transport response to vasopressin in rat cortical collecting duct.	Water	30-35	arginine vasopressin	Rattus norvegicus	58-69
9683734-5	1998	AQP2 with loop B of AQP0 was also routed normally and gave a high water permeability, similar to that of wild-type AQP2.	Water	66-71	aquaporin 2 S homeolog	Xenopus laevis	0-4
9683734-5	1998	AQP2 with loop B of AQP0 was also routed normally and gave a high water permeability, similar to that of wild-type AQP2.	Water	66-71	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	20-24
9683734-4	1998	AQP0 with loop E of AQP2 was not impaired in its routing and revealed a low water permeability equal to that of wild-type AQP0.	Water	76-81	aquaporin 2 S homeolog	Xenopus laevis	20-24
9624156-1	1998	The three-dimensional structure of calcium-loaded regulatory, i.e. N-terminal, domain (1-91) of human cardiac troponin C (cNTnC) was determined by NMR in water/trifluoroethanol (91:9 v/v) solution.	Water	154-159	troponin C1, slow skeletal and cardiac type	Homo sapiens	102-120
9683734-7	1998	However, the plasma membrane expression was high enough to expect an increase in water permeability, as loops B and E of AQP2 confer AQP2"s water permeability to AQP0.	Water	81-86	aquaporin 2 S homeolog	Xenopus laevis	121-125
9683734-7	1998	However, the plasma membrane expression was high enough to expect an increase in water permeability, as loops B and E of AQP2 confer AQP2"s water permeability to AQP0.	Water	81-86	aquaporin 2 S homeolog	Xenopus laevis	133-137
9683734-7	1998	However, the plasma membrane expression was high enough to expect an increase in water permeability, as loops B and E of AQP2 confer AQP2"s water permeability to AQP0.	Water	81-86	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	162-166
9683734-7	1998	However, the plasma membrane expression was high enough to expect an increase in water permeability, as loops B and E of AQP2 confer AQP2"s water permeability to AQP0.	Water	140-145	aquaporin 2 S homeolog	Xenopus laevis	121-125
9683734-7	1998	However, the plasma membrane expression was high enough to expect an increase in water permeability, as loops B and E of AQP2 confer AQP2"s water permeability to AQP0.	Water	140-145	aquaporin 2 S homeolog	Xenopus laevis	133-137
9683734-7	1998	However, the plasma membrane expression was high enough to expect an increase in water permeability, as loops B and E of AQP2 confer AQP2"s water permeability to AQP0.	Water	140-145	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	162-166
9683734-8	1998	Although it is unclear for the dual chimera (AQP0-2BE), the parental water permeabilities obtained in oocytes expressing AQP0 with loop E of AQP2 or AQP2 with loop B of AQP0 indicate that, besides loops B and E, other parts of the AQP protein are important in the determination of the characteristics of the channel.	Water	69-74	aquaporin 2 S homeolog	Xenopus laevis	141-145
9683734-8	1998	Although it is unclear for the dual chimera (AQP0-2BE), the parental water permeabilities obtained in oocytes expressing AQP0 with loop E of AQP2 or AQP2 with loop B of AQP0 indicate that, besides loops B and E, other parts of the AQP protein are important in the determination of the characteristics of the channel.	Water	69-74	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	121-125
10193529-3	1998	BDP has a lower water solubility than either 17-BMP or budesonide, which have similar water solubilities.	Water	16-21	AT-rich interaction domain 3B	Homo sapiens	0-3
10193529-3	1998	BDP has a lower water solubility than either 17-BMP or budesonide, which have similar water solubilities.	Water	86-91	AT-rich interaction domain 3B	Homo sapiens	0-3
9618471-8	1998	Contrary to earlier reports, the present results indicate that a significant fraction of DMPO/.OH formed during the reaction of SOD and familial ALS SOD mutants with H2O2 is derived from the incorporation of oxygen from water due to oxidation of DMPO to DMPO/.OH presumably via DMPO radical cation.	Water	220-225	superoxide dismutase 1	Homo sapiens	128-131
9767808-13	1998	In our patient, the weak vasopressin response to the end of water restriction at post partum when the diabetes insipidus symptoms had disappeared would suggest partial central diabetes insipidus revealed by pregnancy.	Water	60-65	arginine vasopressin	Homo sapiens	25-36
9702011-0	1998	[Diagnosis of water-electrolyte imbalance by analysis of vasopressin and atrial natriuretic hormone].	Water	14-19	arginine vasopressin	Homo sapiens	57-68
9622590-3	1998	Inhibition of ANG II synthesis in unoperated rats with 100 mg/kg of captopril reduced water intake only during the initial 15 min after a gavage of 1200 mOsm/kg saline.	Water	86-91	angiotensinogen	Rattus norvegicus	14-20
9596523-6	1998	The lateral location of XOMP1 and medial location of XOMP2 correspond to the suggested locations of olfactory receptor neurons responsive to water-borne and air-borne odorants, respectively.	Water	141-146	olfactory marker protein S homeolog	Xenopus laevis	24-29
9596523-6	1998	The lateral location of XOMP1 and medial location of XOMP2 correspond to the suggested locations of olfactory receptor neurons responsive to water-borne and air-borne odorants, respectively.	Water	141-146	olfactory marker protein S homeolog	Xenopus laevis	53-58
9630476-2	1998	Upon addition of human serum albumin (HSA), formation of two different ternary adducts of stoichiometry HSA-Ln(MAL)x(H2O)q (x=2, q=2; x=2, q=4) is detected.	Water	117-120	albumin	Homo sapiens	23-36
9686304-4	1998	Following isolation with the standard distilled water washing procedure, the HSPG layer and AA protein filaments detached from their core and dispersed into the water.	Water	48-53	syndecan 2	Mus musculus	77-81
9609747-1	1998	During the perinatal period, a dramatic reversal of lung transepithelial ion and water transport occurs that involves the amiloride-inhibitable Na+ channel (ENaC).	Water	81-86	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	157-161
9609747-8	1998	Exposure to ambient 21% O2 may contribute to increases in AQP-4 and ENaC expression to facilitate water transport across neonatal airway epithelia in the immediate postnatal period.	Water	98-103	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	68-72
9686304-4	1998	Following isolation with the standard distilled water washing procedure, the HSPG layer and AA protein filaments detached from their core and dispersed into the water.	Water	161-166	syndecan 2	Mus musculus	77-81
9693974-3	1998	TNF-alpha activity was neutralized in vivo with a p55 TNF-alpha receptor-Ig fusion protein (sTNFr-Ig), administered 8 and 10 days after induction of EAU with heterologous retinal antigens.	Water	149-152	tumor necrosis factor	Rattus norvegicus	0-9
9841553-2	1998	The physiological state associated with water and sodium ingestion was produced by the concurrent subcutaneous administration of the diuretic furosemide (10 mg/kg) and a low dose of the angiotensin-converting enzyme (ACE) inhibitor captopril (5 mg/kg; Furo/Cap treatment).	Water	40-45	angiotensin I converting enzyme	Rattus norvegicus	217-220
9841555-8	1998	The demonstration of MCT1 on the apical membrane and MCT3 on the basal membrane identifies specific proteins involved in the discriminate and critical regulation of water and lactate transport from the retina to the choroid.	Water	165-170	solute carrier family 16 member 1	Rattus norvegicus	21-25
9841509-1	1998	Previously, we demonstrated that escape from vasopressin-induced antidiuresis ("vasopressin escape") in rats is associated with a large, selective decrease in whole kidney expression of aquaporin-2, the vasopressin-regulated water channel.	Water	225-230	arginine vasopressin	Rattus norvegicus	45-56
9841509-1	1998	Previously, we demonstrated that escape from vasopressin-induced antidiuresis ("vasopressin escape") in rats is associated with a large, selective decrease in whole kidney expression of aquaporin-2, the vasopressin-regulated water channel.	Water	225-230	arginine vasopressin	Rattus norvegicus	80-91
9841509-1	1998	Previously, we demonstrated that escape from vasopressin-induced antidiuresis ("vasopressin escape") in rats is associated with a large, selective decrease in whole kidney expression of aquaporin-2, the vasopressin-regulated water channel.	Water	225-230	arginine vasopressin	Rattus norvegicus	80-91
9841509-2	1998	Here, we show that isolated perfused inner medullary collecting ducts (IMCDs) from vasopressin-escape rats desamino-[D-arginine]vasopressin (DDAVP)/water-loaded have dramatically reduced vasopressin-dependent osmotic water permeabilities [46% of control rats (DDAVP alone)], which coincides with a fall in inner medullary aquaporin-2 protein abundance as measured by immunoblotting in the opposite kidney.	Water	148-153	arginine vasopressin	Rattus norvegicus	83-94
9841509-2	1998	Here, we show that isolated perfused inner medullary collecting ducts (IMCDs) from vasopressin-escape rats desamino-[D-arginine]vasopressin (DDAVP)/water-loaded have dramatically reduced vasopressin-dependent osmotic water permeabilities [46% of control rats (DDAVP alone)], which coincides with a fall in inner medullary aquaporin-2 protein abundance as measured by immunoblotting in the opposite kidney.	Water	217-222	arginine vasopressin	Rattus norvegicus	83-94
9841509-2	1998	Here, we show that isolated perfused inner medullary collecting ducts (IMCDs) from vasopressin-escape rats desamino-[D-arginine]vasopressin (DDAVP)/water-loaded have dramatically reduced vasopressin-dependent osmotic water permeabilities [46% of control rats (DDAVP alone)], which coincides with a fall in inner medullary aquaporin-2 protein abundance as measured by immunoblotting in the opposite kidney.	Water	217-222	arginine vasopressin	Rattus norvegicus	128-139
9841509-2	1998	Here, we show that isolated perfused inner medullary collecting ducts (IMCDs) from vasopressin-escape rats desamino-[D-arginine]vasopressin (DDAVP)/water-loaded have dramatically reduced vasopressin-dependent osmotic water permeabilities [46% of control rats (DDAVP alone)], which coincides with a fall in inner medullary aquaporin-2 protein abundance as measured by immunoblotting in the opposite kidney.	Water	217-222	arginine vasopressin	Rattus norvegicus	128-139
9841509-6	1998	The decreased cAMP levels can contribute to the demonstrated decrease in collecting duct water permeability in two ways: 1) by causing a decrease in aquaporin-2 expression and 2) by limiting the acute action of vasopressin to increase collecting duct water permeability.	Water	89-94	arginine vasopressin	Rattus norvegicus	211-222
9841509-6	1998	The decreased cAMP levels can contribute to the demonstrated decrease in collecting duct water permeability in two ways: 1) by causing a decrease in aquaporin-2 expression and 2) by limiting the acute action of vasopressin to increase collecting duct water permeability.	Water	251-256	arginine vasopressin	Rattus norvegicus	211-222
9841525-5	1998	We suggest that 1) in vivo, under near-isotonic conditions, caveolae may alternate frequently between brief open and closed-off states; 2) aquaporin-1-caveolin-3 colocalization may be energy dependent; and 3) while closed off from the interstitium, each caveola transiently functions as an osmometer that experiences, monitors, and reacts to net water flow from or into the subcaveolar cytosol of the myocyte.	Water	346-351	caveolin 3	Rattus norvegicus	151-161
9635771-5	1998	That result and the equivalent efficiency of Glu64 and Asp64 as proton donors in the catalysis by CA III demonstrate a lack of specificity in proton transfer from these sites, which is indirect evidence of a number of proton conduction pathways through different structures of intervening water chains.	Water	289-294	carbonic anhydrase 3	Homo sapiens	98-104
9720254-4	1998	Here, we report the crystal structure of the pancreatic activated lipase/colipase/micelle complex as determined using the D2O/H2O contrast variation low resolution neutron diffraction method.	Water	126-129	colipase	Homo sapiens	73-81
9678762-2	1998	IL-10-deficient mice were susceptible to EAU, indicating that pathogenesis can occur without presence of IL-10.	Water	41-44	interleukin 10	Mus musculus	0-5
9678762-3	1998	Treatment of normal mice with IL-10 for 5 days after uveitogenic immunization ameliorated subsequent EAU scores, and down-regulated antigen-specific production of tumor necrosis factor-alpha and IFN-gamma.	Water	101-104	interleukin 10	Mus musculus	30-35
9678762-8	1998	Systemic neutralization of IL-10 during the expression phase of EAU resulted in elevated disease scores.	Water	64-67	interleukin 10	Mus musculus	27-32
9704899-2	1998	The localisation of atrial natriuretic peptide (ANP) in the human brain was considered to be both interesting and relevant to the understanding of neurochemistry and brain water-electrolyte homeostasis.	Water	172-177	natriuretic peptide A	Homo sapiens	20-46
9704899-2	1998	The localisation of atrial natriuretic peptide (ANP) in the human brain was considered to be both interesting and relevant to the understanding of neurochemistry and brain water-electrolyte homeostasis.	Water	172-177	natriuretic peptide A	Homo sapiens	48-51
11324577-6	1998	The result also showed that prior to the incubation in 43 degrees C water bath for 30 min strongly increased IL-6 release 6 h (P &lt; 0.05) after HSR.	Water	68-73	interleukin 6	Rattus norvegicus	109-113
9710328-6	1998	Therefore, altered water metabolism resulting from inappropriate release and/or response to arginine vasopressin (AVP) is proposed as a pathophysiological basis of certain chronic fatigue disorders.	Water	19-24	arginine vasopressin	Homo sapiens	101-112
9626295-8	1998	However, when either thrombolytic was infused concomitantly with thrombin (1 or 5 U), brain water, sodium, and potassium content all demonstrated a potentiation of thrombin-induced brain injury (P &lt; 0.05).	Water	92-97	coagulation factor II	Rattus norvegicus	164-172
9659395-0	1998	X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture.	Water	64-69	lysozyme	Homo sapiens	30-38
18273271-4	1998	Numerical results are compared with experimental data of a 10-mum wire located in water 50.0 mm from a 10-mm-thick glass window, and good agreement is demonstrated.	Water	82-87	latexin	Homo sapiens	62-65
9593782-2	1998	In Xenopus oocytes expressing AQP2 cRNAs, single-channel water permeabilities of mutants L22V, T126M, and A147T were similar to that of wild-type AQP2, whereas R187C and C181W were nonfunctional.	Water	57-62	aquaporin 2 S homeolog	Xenopus laevis	30-34
9612245-7	1998	Food intake was not altered, but water intake was increased in ANG II-infused rats.	Water	33-38	angiotensinogen	Rattus norvegicus	63-69
9652391-4	1998	Only the water-soluble hexacarboxylic acid derivative of C60 was found to prevent TGF-beta-induced apoptosis.	Water	9-14	transforming growth factor beta 1	Homo sapiens	82-90
9572868-6	1998	Using two different methods to analyze Forster resonance energy transfer, the distance of the Pgp-bound probes from the lipid-water interfacial region of the bilayer was estimated to be 31-35 A.	Water	126-131	ATP binding cassette subfamily B member 1	Homo sapiens	94-97
9612221-9	1998	These studies demonstrate selective expression of AQP1, AQP3, AQP4, and AQP5 in distinct ocular epithelia, predicting specific roles for each in the complex network through which water movements occur in the eye.	Water	179-184	aquaporin 1 (Colton blood group)	Homo sapiens	50-54
9578548-11	1998	The acyl-enzyme inhibitor hydroxyl is properly positioned for nucleophilic attack on the ester carbonyl and therefore relactonization; furthermore, the higher resolution structure of alpha-thrombin/GR133487 shows this hydroxyl to be effectively superimposable with the recently proposed deacylating water for peptide substrate hydrolysis [Wilmouth, R. C., et al.	Water	299-304	coagulation factor II, thrombin	Homo sapiens	189-197
9630829-13	1998	CONCLUSIONS: Even though a hyporesponsiveness was observed in the group of patients with cirrhosis compared with the healthy group, the novel vasopressin-2 antagonist induced hypotonic diuresis in patients with cirrhosis, suggesting a therapeutic potential in managing water excess.	Water	269-274	arginine vasopressin	Homo sapiens	142-153
9612328-0	1998	Regional time-dependent changes in vasopressin V2 receptor expression in the rat kidney during water restriction.	Water	95-100	arginine vasopressin receptor 2	Rattus norvegicus	35-58
9612328-1	1998	Elevations of arginine vasopressin (AVP) binding to renal vasopressin V2 receptors (V2R) enhance water and urea reabsorption in the collecting duct epithelium.	Water	97-102	arginine vasopressin	Rattus norvegicus	23-34
9612328-1	1998	Elevations of arginine vasopressin (AVP) binding to renal vasopressin V2 receptors (V2R) enhance water and urea reabsorption in the collecting duct epithelium.	Water	97-102	arginine vasopressin	Rattus norvegicus	58-69
9612328-1	1998	Elevations of arginine vasopressin (AVP) binding to renal vasopressin V2 receptors (V2R) enhance water and urea reabsorption in the collecting duct epithelium.	Water	97-102	arginine vasopressin receptor 2	Rattus norvegicus	84-87
9612328-2	1998	This study was designed to quantify the levels of V2R mRNA and protein within the distinct regions of the Sprague-Dawley rat kidney (i.e., the cortex and outer and inner medulla) during 24 and 48 h of water restriction.	Water	201-206	arginine vasopressin receptor 2	Rattus norvegicus	50-53
9612328-5	1998	The results showed that the steady-state levels of the V2R mRNA decreased in a time-dependent manner in the cortex and outer and inner medulla throughout 48 h of water restriction.	Water	162-167	arginine vasopressin receptor 2	Rattus norvegicus	55-58
9612328-6	1998	Western blot analysis revealed that the V2R protein in the renal cortex decreased after the initial 24 h of water restriction and remained decreased at 48 h. In contrast, outer medullary V2R protein decreased significantly only after 48 h of water restriction, whereas no significant change in the inner medullary V2R protein was observed throughout the 48 h of water restriction.	Water	108-113	arginine vasopressin receptor 2	Rattus norvegicus	40-43
9612328-7	1998	These results suggest that water restriction leads to a regional time-dependent downregulation of the V2R mRNA and protein within the rat kidney.	Water	27-32	arginine vasopressin receptor 2	Rattus norvegicus	102-105
9612328-8	1998	The stability of the plasma membrane V2R protein within the inner medulla may allow for the optimization of urine concentration and minimize water loss during periods of water restriction.	Water	141-146	arginine vasopressin receptor 2	Rattus norvegicus	37-40
9612328-8	1998	The stability of the plasma membrane V2R protein within the inner medulla may allow for the optimization of urine concentration and minimize water loss during periods of water restriction.	Water	170-175	arginine vasopressin receptor 2	Rattus norvegicus	37-40
9623770-4	1998	The procedure is also suitable for a rapid and reliable assay of the water-soluble phospholipase A2 activity; the relationship between the aggregation state of substrate phospholipids (mixed micelles, multilamellar and unilamellar vesicles) and the enzyme activity has been studied.	Water	69-74	phospholipase A2 group IB	Homo sapiens	83-99
9692673-2	1998	Neuronal AT1 receptors mediate the stimulatory actions of Ang II on blood pressure, water and salt intake, and secretion of vasopressin.	Water	84-89	angiotensinogen	Homo sapiens	58-64
9612336-5	1998	Physiological doses of desmopressin reproduced the effects of water deprivation on mRNA and intracellular protein levels, suggesting that pIgR expression may be regulated by a vasopressin-coupled mechanism.	Water	62-67	arginine vasopressin	Rattus norvegicus	176-187
9612337-0	1998	Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats.	Water	21-26	arginine vasopressin	Rattus norvegicus	0-11
9612337-1	1998	To investigate how hypercalcemia blunts renal concentrating ability, alterations in basal and arginine vasopressin (AVP)-elicited osmotic water (Pf) and urea (Purea) permeabilities were measured in isolated perfused terminal inner medullary collecting ducts (IMCD) from control and chronically hypercalcemic rats after dihydrotachysterol (DHT) (M. Levi, L. Peterson, and T. Berl.	Water	138-143	arginine vasopressin	Rattus norvegicus	103-114
9621410-0	1998	Synthesis and evaluation of water-soluble non-prodrug analogs of docetaxel bearing sec-aminoethyl group at the C-10 position.	Water	28-33	homeobox C10	Homo sapiens	111-115
9705080-8	1998	The apparent Km and Vmax estimated by the release of [3H]water was 5.8+/-0.6 nM and 10.8+/-1.4 pmol/mg per 6 h in the presence of DEX + IL-1beta.	Water	57-62	interleukin 1 beta	Homo sapiens	136-144
9654063-6	1998	The results of the present study exclude Fenton-type chemistry and prove that the minicatalyst is able to catalyze the oxygen incorporation by both peroxidase and cytochrome P-450 types of reaction pathways, while exchange occurs between the high-valency iron-oxo species and H2O.	Water	276-279	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	163-179
9572809-7	1998	With water ingestion, plasma catecholamines increased significantly, whereas insulin fell (P &lt; 0.05).	Water	5-10	insulin	Homo sapiens	77-84
9691674-8	1998	A study of this region using the published 3 dimensional x-ray crystallographic structure of l-asparaginase revealed that the C-terminal region is exposed and can interact with water.	Water	177-182	asparaginase and isoaspartyl peptidase 1	Homo sapiens	93-107
9545259-11	1998	These results indicate that UT3 functions as a urea/water channel utilizing a common aqueous pathway.	Water	52-57	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	28-31
9570029-1	1998	Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel of the renal collecting duct and is excreted in human urine.	Water	47-52	arginine vasopressin	Homo sapiens	25-36
9545259-0	1998	Urea transporter UT3 functions as an efficient water channel.	Water	47-52	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	17-20
9545259-7	1998	UT3-mediated water and urea transport were weakly temperature-dependent (activation energy &lt;4 kcal/mol), inhibited &gt; 75% by the urea transport inhibitor 1,3-dimethylthiourea, but not inhibited by the water transport inhibitor HgCl2.	Water	13-18	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	0-3
9545259-7	1998	UT3-mediated water and urea transport were weakly temperature-dependent (activation energy &lt;4 kcal/mol), inhibited &gt; 75% by the urea transport inhibitor 1,3-dimethylthiourea, but not inhibited by the water transport inhibitor HgCl2.	Water	206-211	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	0-3
9570032-6	1998	Increased stool number was noted in infants in group C. Increased VIP levels in jaundiced infants under phototherapy may be the cause of increased stool frequency, through stimulation of intestinal water and electrolyte secretion.	Water	198-203	vasoactive intestinal peptide	Homo sapiens	66-69
9627397-1	1998	Animal fibrous proteins (AFPs) such as egg-shell membrane (ESM), chicken feather (CF), wool, silk, or elastin are an intricate network of stable and water-insoluble fibers with high surface area and are abundant bioresources.	Water	149-154	elastin	Gallus gallus	102-109
9648521-1	1998	This study deals with the production of chitosan microparticles containing insulin by interfacial crosslinkage of chitosan solubilized in the aqueous phase of a water/oil dispersion in the presence of ascorbyl palmitate.	Water	161-166	insulin	Homo sapiens	75-82
9570001-5	1998	Nifedipine plasma concentration-time profiles in the GJRS, OJRS, and (tap) water groups displayed a single peak.	Water	75-80	nuclear RNA export factor 1	Rattus norvegicus	70-73
9545028-9	1998	Analysis of solvent structure reveals an inhomogeneity in the mobility of water in the vicinity of the protein, which is attributable to the hydrophobic effect exerted by calmodulin"s binding sites for target peptides.	Water	74-79	calmodulin 1	Homo sapiens	171-181
9578279-3	1998	RESULTS: Water deprivation-vasopressin administration tests demonstrated partial central DI, corrected with vasopressin in week 12, but only with desmopressin in the third trimester, when placental cystylamino peptidase (vasopressinase) contributes to the severity of the DI.	Water	9-14	arginine vasopressin	Homo sapiens	27-38
9532733-4	1998	A comparison of the results of PCB-quantification in unfiltered water samples with the results for solid phase material (SPM-phase) in river water is presented.	Water	64-69	pyruvate carboxylase	Homo sapiens	31-34
9531515-2	1998	In the present study, we describe a non-high pressure liquid chromatography assay (HPLC) of CYP3A4/5 activity based on the release of tritium (with formation of tritiated water) upon incubation of [1,2,6,7-3H]testosterone with human liver microsomes and NADPH.	Water	171-176	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	92-98
9604313-0	1998	Characterization of Aplysia attractin, the first water-borne peptide pheromone in invertebrates.	Water	49-54	attractin	Homo sapiens	28-37
9604313-12	1998	Attractin is the first water-borne peptide pheromone characterized in molluscs, and the first in invertebrates.	Water	23-28	attractin	Homo sapiens	0-9
9528924-7	1998	Moreover, the AVP messenger RNA levels in PVN and SON in the APX group were also significantly lower than in the Sham group after water deprivation for 3 days.	Water	130-135	arginine vasopressin	Rattus norvegicus	14-17
9578279-3	1998	RESULTS: Water deprivation-vasopressin administration tests demonstrated partial central DI, corrected with vasopressin in week 12, but only with desmopressin in the third trimester, when placental cystylamino peptidase (vasopressinase) contributes to the severity of the DI.	Water	9-14	arginine vasopressin	Homo sapiens	108-119
9630397-3	1998	The highest dose of ANG II and ANG III also induced drinking responses of 4.3+/-0.78 and 2.91+/-0.54 ml water/15 min, respectively.	Water	104-109	angiotensinogen	Rattus norvegicus	20-26
9514918-0	1998	Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.	Water	123-128	aquaporin 9	Homo sapiens	54-58
9514766-2	1998	To complement experiment and to obtain more detailed information about the structure and dynamic behavior of the denatured state, we have performed eleven 2.5 ns molecular dynamics simulations of reduced bovine pancreatic trypsin inhibitor (BPTI) at high temperature in water and a control simulation at 298 K, for a total of 30 ns of simulation time.	Water	270-275	trophoblast Kunitz domain protein 1	Bos taurus	222-239
9490810-16	1998	The finding of a molecular water pump allows for new models of cellular water transport which include coupling between ion and water fluxes at the protein level; the hSGLT1 could account for almost half the daily reuptake of water from the small intestine.	Water	27-32	solute carrier family 5 member 1	Homo sapiens	166-172
9490810-16	1998	The finding of a molecular water pump allows for new models of cellular water transport which include coupling between ion and water fluxes at the protein level; the hSGLT1 could account for almost half the daily reuptake of water from the small intestine.	Water	72-77	solute carrier family 5 member 1	Homo sapiens	166-172
9490810-16	1998	The finding of a molecular water pump allows for new models of cellular water transport which include coupling between ion and water fluxes at the protein level; the hSGLT1 could account for almost half the daily reuptake of water from the small intestine.	Water	72-77	solute carrier family 5 member 1	Homo sapiens	166-172
9490810-16	1998	The finding of a molecular water pump allows for new models of cellular water transport which include coupling between ion and water fluxes at the protein level; the hSGLT1 could account for almost half the daily reuptake of water from the small intestine.	Water	72-77	solute carrier family 5 member 1	Homo sapiens	166-172
9559655-0	1998	Solution conformation of an ET(B) selective agonist, ET-1[Cys(Acm)1,15,Ala3,Leu7,Aib11], in CD3OH/H2O by 1H NMR and molecular modelling.	Water	98-101	beta-1,3-glucuronyltransferase 1	Homo sapiens	76-80
9497312-2	1998	Like the kidney, the eye contains multiple water channel proteins (aquaporins) that transport water through membranes, including two (AQP1 and AQP4) in the ciliary body, the site of aqueous humor production.	Water	43-48	aquaporin 1 (Colton blood group)	Homo sapiens	134-138
9497312-3	1998	However, because humans with defective AQP1 are phenotypically normal and because the ocular application of phorbol esters reduce intraocular pressure, we postulated that the water channel activity of AQP4 may be regulated by these agents.	Water	175-180	aquaporin 1 (Colton blood group)	Homo sapiens	39-43
9546200-0	1998	NMR triple-quantum filtered relaxation analysis of 17O-water in insulin solutions: an insight into the aggregation of insulin and the properties of its bound water.	Water	55-60	insulin	Homo sapiens	64-71
9518582-3	1998	Monolayers of pure SP-B or SP-C isolated from butanol lipid extracts spread at the air-water interface showed larger molecular areas than those determined in films of SP-B or SP-C isolated from chloroform surfactant extracts.	Water	87-92	surfactant protein C	Homo sapiens	27-31
9518582-4	1998	Aqueous dispersions of dipalmitoylphosphatidylcholine (DPPC) supplemented with 2.5 and 5.0 wt% of SP-B or SP-C obtained from butanol extracts adsorbed faster to the air-water interface than their counterparts reconstituted with proteins isolated from chloroform extracts.	Water	169-174	surfactant protein C	Homo sapiens	106-110
9514918-4	1998	Injection of AQP9-cRNA into Xenopus oocytes stimulated the osmotic water permeability 7-folds with a low activation energy (4.2 kcal/mol) which was inhibited by 0.3 mM mercury chloride by 48%.	Water	67-72	aquaporin 9	Homo sapiens	13-17
9514918-8	1998	The possible role of AQP9 in the immunological function of leukocytes is intriguing and the identification of AQP9 with unique permeability profile may expand our understanding of water and small solute transport in the body.	Water	180-185	aquaporin 9	Homo sapiens	110-114
9485441-2	1998	Microsomal epoxide hydrolase (MEH) catalyzes the addition of water to epoxides in a two-step reaction involving initial attack of an active site carboxylate on the oxirane to give an ester intermediate followed by hydrolysis of the ester.	Water	61-66	epoxide hydrolase 1	Rattus norvegicus	0-28
9546200-0	1998	NMR triple-quantum filtered relaxation analysis of 17O-water in insulin solutions: an insight into the aggregation of insulin and the properties of its bound water.	Water	55-60	insulin	Homo sapiens	118-125
9546200-0	1998	NMR triple-quantum filtered relaxation analysis of 17O-water in insulin solutions: an insight into the aggregation of insulin and the properties of its bound water.	Water	158-163	insulin	Homo sapiens	64-71
9546200-1	1998	Transverse triple-quantum filtered NMR spectroscopy (TTQF) of 17O-water was used to study the properties of water in insulin solutions at different Zn2+ concentrations and pH values.	Water	108-113	insulin	Homo sapiens	117-124
9546200-2	1998	It was established that strongly bound water molecules are already present in Zn-free insulin.	Water	39-44	insulin	Homo sapiens	86-93
9546200-3	1998	On the assumption that the effective correlation time of a strongly bound water molecule, tau sb, is 10 ns, the apparent number of strongly bound water molecules was approximately 3 to 4 per insulin monomer.	Water	74-79	insulin	Homo sapiens	191-198
9546200-3	1998	On the assumption that the effective correlation time of a strongly bound water molecule, tau sb, is 10 ns, the apparent number of strongly bound water molecules was approximately 3 to 4 per insulin monomer.	Water	146-151	insulin	Homo sapiens	191-198
9485441-2	1998	Microsomal epoxide hydrolase (MEH) catalyzes the addition of water to epoxides in a two-step reaction involving initial attack of an active site carboxylate on the oxirane to give an ester intermediate followed by hydrolysis of the ester.	Water	61-66	epoxide hydrolase 1	Rattus norvegicus	30-33
9685935-2	1998	L-Asparaginase was encapsulated in PLG nanospheres using a water-in-oil-in-water solvent evaporation technique.	Water	59-64	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
9685935-2	1998	L-Asparaginase was encapsulated in PLG nanospheres using a water-in-oil-in-water solvent evaporation technique.	Water	75-80	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
9524553-4	1998	In MeCN/H2O electrochemical reduction is irreversible, indicating rapid substitution of H2O into the coordination sphere of the Co(II) intermediate.	Water	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
9524553-4	1998	In MeCN/H2O electrochemical reduction is irreversible, indicating rapid substitution of H2O into the coordination sphere of the Co(II) intermediate.	Water	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
9528693-0	1998	Identification and determination of low-molecular weight organic compounds in contaminated fog water using proton nuclear magnetic resonance spectroscopy.	Water	95-100	zinc finger protein, FOG family member 1	Homo sapiens	91-94
9512049-0	1998	Low-frequency Raman spectra of lysozyme crystals and oriented DNA films: dynamics of crystal water.	Water	93-98	lysozyme	Homo sapiens	31-39
9568746-4	1998	Currently, the cause of BFD is believed to be artesian drinking water containing a high concentration of arsenic and/or humic substances, although the mechanism of EC destruction is not entirely understood.	Water	64-69	complement factor properdin	Homo sapiens	24-27
9527870-4	1998	The equilibrium phase diagram of Me2SO is found to be eutectic with two compounds formed of water and Me2SO in the ratio of 3:1 and 2:1.	Water	92-97	malic enzyme 2	Homo sapiens	33-36
9606255-0	1998	Identification and Determination of Low-Molecular Weight Organic Compounds in Contaminated Fog Water Using Proton Nuclear Magnetic Resonance Spectroscopy	Water	95-100	zinc finger protein, FOG family member 1	Homo sapiens	91-94
9531426-10	1998	Overall, the turn-like structural motifs in the C-terminal region of the peptide in both H2O and DMSO (but not in TFE) agreed with the biologically important conformations obtained earlier by the structure-function analysis of a panel of C5a agonist peptides.	Water	89-92	complement C5a receptor 1	Homo sapiens	238-241
9501916-1	1998	Folding of cytochrome c from its low pH guanidine hydrochloride (Gdn-HCl) denatured state revealed a new intermediate, a five-coordinate high spin species with a water molecule coordinated to the heme.	Water	162-167	cytochrome c, somatic	Homo sapiens	11-23
9501916-3	1998	In this new model, unfolded cytochrome c is converted to its native structure through an obligatory folding intermediate, the histidine-water coordination state, whereas the five-coordinate state and a bis-histidine state are off-pathway intermediates.	Water	136-141	cytochrome c, somatic	Homo sapiens	28-40
9769915-1	1998	Arterial tone and water-electrolyte homeostasis are regulated by several peptides, including angiotensin II (AII), bradykinin (BK), atrial natriuretic peptide (ANP) and endothelins (ETs).	Water	18-23	angiotensinogen	Rattus norvegicus	93-107
9548645-4	1998	The water absorption response could be induced by intraperitoneal and intracerebroventricular injection of angiotensin II, demonstrating that components of the renin-angiotensin system on both sides of the blood-brain barrier have a dipsogenic function in amphibians.	Water	4-9	angiotensinogen	Homo sapiens	107-121
9548645-4	1998	The water absorption response could be induced by intraperitoneal and intracerebroventricular injection of angiotensin II, demonstrating that components of the renin-angiotensin system on both sides of the blood-brain barrier have a dipsogenic function in amphibians.	Water	4-9	renin	Homo sapiens	160-165
9445403-0	1998	Hydrogen bonding changes of internal water molecules in rhodopsin during metarhodopsin I and metarhodopsin II formation.	Water	37-42	rhodopsin	Homo sapiens	56-65
9452503-2	1998	At micromolar concentration in water, LL-37 exhibits a circular dichroism spectrum consistent with a disordered structure.	Water	31-36	cathelicidin antimicrobial peptide	Homo sapiens	38-43
9863366-9	1998	Renal V2 receptors mediate vasopressin-induced water reabsorption via induction of intracellular cAMP production in collecting duct cells.	Water	47-52	arginine vasopressin	Homo sapiens	27-38
9523923-0	1998	Effects of L-arginine on angiotensin II-related water and salt intakes.	Water	48-53	angiotensinogen	Rattus norvegicus	25-39
9523923-5	1998	We confirmed that icv administration of L-arg (50 microg) reduced water intakes induced by both 24 h water deprivation and icv Ang II (250 ng).	Water	66-71	angiotensinogen	Rattus norvegicus	127-133
9523923-6	1998	We additionally showed that L-arg inhibited the water intake induced by peripheral injection of Ang II and the intake of 0.3 M NaCl following 24 h sodium depletion.	Water	48-53	angiotensinogen	Rattus norvegicus	96-102
9486146-10	1998	Coexpression of AQP3 and AQP4 in Xenopus laevis oocytes showed additive water permeabilities, suggesting that AQP4 deletion does not affect AQP3 function.	Water	72-77	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	16-20
9445403-5	1998	Compared with earlier work, several negative bands associated with water molecules in unphotolysed rhodopsin were detected, which shift to lower frequencies upon formation of the Meta I and Meta II intermediates.	Water	67-72	rhodopsin	Homo sapiens	99-108
9569067-5	1998	This result can be interpreted as indicating that lubricin is not the lubricant per se, but, as a water-soluble, macromolecular, proteinaceous carrier for phospholipid, its destruction caused more SAPL to be deposited as the true load-bearing lubricant.	Water	98-103	proteoglycan 4	Bos taurus	50-58
9490052-1	1998	Two- and three-dimensional heteronuclear NMR experiments have been performed to identify internally bound water molecules in the solution structure of bovine heart fatty-acid-binding protein (heart FABP).	Water	106-111	fatty acid binding protein 3	Bos taurus	198-202
9490052-2	1998	NOE and rotating-frame NOE (ROE) cross peaks between protein protons and protons of bound water molecules were observed in two-dimensional H2O-ROE/NOE-1H,15N-heteronuclear single quantum coherence spectra recorded from a uniformly 13C/15N-enriched sample of bovine heart FABP.	Water	90-95	fatty acid binding protein 3	Bos taurus	271-275
9490052-2	1998	NOE and rotating-frame NOE (ROE) cross peaks between protein protons and protons of bound water molecules were observed in two-dimensional H2O-ROE/NOE-1H,15N-heteronuclear single quantum coherence spectra recorded from a uniformly 13C/15N-enriched sample of bovine heart FABP.	Water	139-142	fatty acid binding protein 3	Bos taurus	271-275
9490052-7	1998	In the delipidated heart FABP additional contacts between water molecules and NH protons could be observed using a three-dimensional rotating frame Overhauser 1H,15N heteronuclear single quantum coherence experiment obtained with a 15N-labeled sample of apo-heart FABP.	Water	58-63	fatty acid binding protein 3	Bos taurus	25-29
9490052-7	1998	In the delipidated heart FABP additional contacts between water molecules and NH protons could be observed using a three-dimensional rotating frame Overhauser 1H,15N heteronuclear single quantum coherence experiment obtained with a 15N-labeled sample of apo-heart FABP.	Water	58-63	fatty acid binding protein 3	Bos taurus	264-268
9480747-4	1998	After butyrate-induced erythroid differentiation, AQP1 transcript expression increased strongly, producing water-permeable cells with plasma membrane localization of immunoreactive AQP1.	Water	107-112	aquaporin 1 (Colton blood group)	Homo sapiens	50-54
9450593-6	1998	In addition, the water plant"s radium laden iron filters contributed 7 Bq L-1 and 60 Bq L-1 of 222Rn to the finished water in What Cheer, Iowa, and Wellman, Iowa, respectively.	Water	17-22	L1 cell adhesion molecule	Homo sapiens	74-100
9457545-7	1998	As indicated by increased alkaline phosphatase-specific activity, increased cell-surface and matrix-associated protein, and 1.25 (OH2) vitamin D3-stimulated osteocalcin production, a more differentiated osteoblast-like phenotype was observed on the sintered HA surfaces compared to the as-received HA and calcined HA surfaces.	Water	130-133	bone gamma-carboxyglutamate protein	Homo sapiens	157-168
9480747-1	1998	Water channel aquaporin-1 (AQP1) is expressed in erythrocytes and various epithelia and endothelia.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	14-25
9480747-1	1998	Water channel aquaporin-1 (AQP1) is expressed in erythrocytes and various epithelia and endothelia.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	27-31
10923422-1	1998	OBJECTIVE: To study aquaporin-2 (AQP2) that mediates vasopressin-regulated collecting duct water permeability.	Water	91-96	arginine vasopressin	Rattus norvegicus	53-64
9476992-7	1998	All rats drinking caffeine showed tolerance to its locomotor stimulant effects, whereas rats drinking drug-free tap water did not.	Water	116-121	nuclear RNA export factor 1	Rattus norvegicus	112-115
9507489-1	1998	We have measured the peak scatter factor (PSF) for electron beams which in analogy to photon beams is defined as the ratio of the absorbed dose to water at the depth of dose maximum in a water phantom to the absorbed dose in free air at the same location for a given incident beam.	Water	147-152	insulin like growth factor binding protein 7	Homo sapiens	21-40
9507489-1	1998	We have measured the peak scatter factor (PSF) for electron beams which in analogy to photon beams is defined as the ratio of the absorbed dose to water at the depth of dose maximum in a water phantom to the absorbed dose in free air at the same location for a given incident beam.	Water	147-152	insulin like growth factor binding protein 7	Homo sapiens	42-45
9507489-1	1998	We have measured the peak scatter factor (PSF) for electron beams which in analogy to photon beams is defined as the ratio of the absorbed dose to water at the depth of dose maximum in a water phantom to the absorbed dose in free air at the same location for a given incident beam.	Water	187-192	insulin like growth factor binding protein 7	Homo sapiens	21-40
9507489-1	1998	We have measured the peak scatter factor (PSF) for electron beams which in analogy to photon beams is defined as the ratio of the absorbed dose to water at the depth of dose maximum in a water phantom to the absorbed dose in free air at the same location for a given incident beam.	Water	187-192	insulin like growth factor binding protein 7	Homo sapiens	42-45
9581026-7	1998	The DBA strain reached the highest whole-body steady state level of mercury (19 micrograms Hg) whereas B10.S mice, when considering the drinking water consumption, had the lowest steady-state retention of mercury (15 micrograms Hg).	Water	145-150	granzyme C	Mus musculus	103-106
9537672-2	1998	Moreover, plasma and gastric mucosal endothelin-1 (ET-1) levels rose appreciably in a time-related manner during water immersion, with a higher concentration detected in gastric mucosa.	Water	113-118	endothelin 1	Rattus norvegicus	37-49
9537672-2	1998	Moreover, plasma and gastric mucosal endothelin-1 (ET-1) levels rose appreciably in a time-related manner during water immersion, with a higher concentration detected in gastric mucosa.	Water	113-118	endothelin 1	Rattus norvegicus	51-55
9537672-3	1998	Thus, the percentage increases in plasma (gastric mucosal) ET-1, relative to basal levels, after 1, 4 and 8 h of water immersion were 86(172), 169(322) and 210(391)%, respectively.	Water	113-118	endothelin 1	Rattus norvegicus	59-63
9580081-2	1998	After irradiation the water samples were preconcentrated using C18 solid-phase disk extraction and analysis by gas chromatography-electron capture and mass spectrometric detection.	Water	22-27	Bardet-Biedl syndrome 9	Homo sapiens	63-66
10026831-1	1998	In animal models of the syndrome of inappropriate antidiuresis (SIADH), sustained administration of vasopressin and water results in free-water retention and progressive hyponatremia for several days, which is then followed by escape from the vasopressin-induced antidiuresis.	Water	116-121	arginine vasopressin	Rattus norvegicus	243-254
10026831-11	1998	Our results therefore suggest that escape from vasopressin-induced antidiuresis is attributable, at least in part, to a vasopressin-independent and osmolality-independent decrease in aquaporin-2 water channel expression in the renal collecting duct.	Water	195-200	arginine vasopressin	Rattus norvegicus	47-58
9458917-8	1998	Our data suggest that E2 augments osmotic AVP secretion, thereby implicating elevated AVP as a contributor to water retention in high E2 states; however, an increase in renal sodium reabsorption was a major component of the enhanced fluid retention.	Water	110-115	arginine vasopressin	Homo sapiens	86-89
9871450-1	1998	Blood-borne angiotensin II (AngII) is known to mediate water-intake by its excitatory effect on neurons in the subfornical organ (SFO).	Water	55-60	angiotensinogen	Rattus norvegicus	12-26
9871450-1	1998	Blood-borne angiotensin II (AngII) is known to mediate water-intake by its excitatory effect on neurons in the subfornical organ (SFO).	Water	55-60	angiotensinogen	Rattus norvegicus	28-33
9575638-3	1998	The fall in urine osmolality is mainly due to a reduction of free water reabsorption which is associated with a suppression of insensible water loss and the attendant inhibition of antidiuretic hormone (ADH) system.	Water	66-71	arginine vasopressin	Homo sapiens	181-201
9646871-1	1998	Cytochrome c oxidase, the terminal enzyme of the respiratory chains of mitochondria and aerobic bacteria, catalyzes electron transfer from cytochrome c to molecular oxygen, reducing the latter to water.	Water	196-201	cytochrome c, somatic	Homo sapiens	0-12
9646871-1	1998	Cytochrome c oxidase, the terminal enzyme of the respiratory chains of mitochondria and aerobic bacteria, catalyzes electron transfer from cytochrome c to molecular oxygen, reducing the latter to water.	Water	196-201	cytochrome c, somatic	Homo sapiens	139-151
9833105-9	1998	When administering bradykinin, MRI scans taken immediately after completion of the experiment showed substantial oedema in the femoral muscular system, but without any changes of osseous signals in T1- or short time inversion recovery (STIR)-weighted images, nor did any changes occur when solutions of 20% NaCl or distilled H2O were injected.	Water	325-328	kininogen 1	Canis lupus familiaris	19-29
9575638-3	1998	The fall in urine osmolality is mainly due to a reduction of free water reabsorption which is associated with a suppression of insensible water loss and the attendant inhibition of antidiuretic hormone (ADH) system.	Water	66-71	arginine vasopressin	Homo sapiens	203-206
9858984-0	1998	[Immobilized catalase in water purification systems].	Water	25-30	catalase	Homo sapiens	13-21
9858984-10	1998	Catalase included in cellulase triacetate has effectively functioned during a period of 2 years purifying the distilled water containing 50 mg/l of hydrogen peroxide.	Water	120-125	catalase	Homo sapiens	0-8
9923693-2	1998	Histatin 5 has no defined structure in H2O but adopts a more helical conformation in dimethyl sulfoxide and aqueous trifluoroethanol.	Water	39-42	histatin 3	Homo sapiens	0-10
9477163-0	1998	Augmentation of sinecomitant immunity in mice by gamma-(9H-purine-6-yl)thiomethyl L-glutamate (6-MPG), a water-soluble derivative of 6-mercaptopurine.	Water	105-110	N-methylpurine-DNA glycosylase	Mus musculus	97-100
9477163-1	1998	Effects of the administration of gamma-(9H-purine-6-yl)thiomethyl L-glutamate (6-MPG), a water-soluble derivative of 6-mercaptopurine, on concomitant and sinecomitant immunity against the implanted MethA tumor were studied in BALB/c mice.	Water	89-94	N-methylpurine-DNA glycosylase	Mus musculus	81-84
9923693-5	1998	The NMR analysis of H3 in H2O at pH 7.4 reveals that its conformational mobility is less than that of H5 as indicated by the observation of backbone cross peaks alphaN (i, i + 1) and NN (i, i + 1) and the slow exchanging amide protons in the C-terminus.	Water	26-29	histatin 3	Homo sapiens	20-22
9701701-0	1998	Water and sodium retention during short-term administration of growth hormone to short normal children.	Water	0-5	growth hormone 1	Homo sapiens	63-77
9433185-1	1998	The solution structure of human salivary histatin 5 (D-S-H-A-K-R-H-H-G-Y-K-R-K-F-H-E-K-H-H-S-H-R-G-Y) was examined in water (pH 3.8) and dimethyl sulfoxide solutions using 500 MHz homo- and heteronuclear two-dimensional (2D) nmr.	Water	118-123	histatin 3	Homo sapiens	41-51
27392566-4	1998	The obtained (R)- and (S)-ACE were efficiently recrystallized from water, taking account of the solubility of (RS)-ACE, to give them in optically pure form.	Water	67-72	angiotensin I converting enzyme	Homo sapiens	26-29
27392566-4	1998	The obtained (R)- and (S)-ACE were efficiently recrystallized from water, taking account of the solubility of (RS)-ACE, to give them in optically pure form.	Water	67-72	angiotensin I converting enzyme	Homo sapiens	115-118
9806939-0	1998	Anatomy by computer experiment of the exchange of a water molecule buried in human apolipoprotein E.	Water	52-57	apolipoprotein E	Homo sapiens	83-99
9806939-3	1998	RESULTS: The exchange of a crystal water molecule buried in the low-density lipoprotein receptor-binding domain of human apolipoprotein E with a water molecule from the external solvent was detected and monitored in a molecular dynamics simulation.	Water	35-40	apolipoprotein E	Homo sapiens	121-137
9806939-3	1998	RESULTS: The exchange of a crystal water molecule buried in the low-density lipoprotein receptor-binding domain of human apolipoprotein E with a water molecule from the external solvent was detected and monitored in a molecular dynamics simulation.	Water	145-150	apolipoprotein E	Homo sapiens	121-137
9556762-4	1998	It was found that the PEO containing polyurethanes absorbed large amounts of water while the PCL containing ones did not, indicating a large difference in bulk hydrophilicity.	Water	77-82	twinkle mtDNA helicase	Homo sapiens	22-25
9453338-19	1998	We conclude that during adolescent development, Ang II may be an important factor in the regulation of salt and water metabolism, but not renal hemodynamics.	Water	112-117	angiotensinogen	Rattus norvegicus	48-54
9493069-2	1998	Water soluble polymer (PEG Mw = 20 KD) beads of 100-150 microns were added (12% by volume) to the fibrinogen to obtain a porous and rough structure.	Water	0-5	fibrinogen beta chain	Homo sapiens	98-108
9469597-15	1998	This model is based on the dominant role CER 1 plays in the formation of the long periodicity phase, electron density distribution calculations, and observations, such as i) the bimodal distribution of the fatty acid chain lengths of the ceramides, ii) the phase separation between long-chain ceramides and short-chain ceramides in a monolayer approach, and iii) the absence of swelling of the lamellae upon increasing the water content organization in SC.	Water	423-428	CER1	Sus scrofa	41-46
9491923-0	1998	Kinetic studies on the initial crystallization process of lysozyme in the presence of D2O and H2O.	Water	94-97	lysozyme	Homo sapiens	58-66
9705571-6	1998	Pretreatment with hydrocortisone normalized the response of plasma vasopressin to the water load was well as the diuretic response during the hypothyroid state.	Water	86-91	arginine vasopressin	Homo sapiens	67-78
9491923-6	1998	Lysozyme showed a critical concentration for nucleus formation whose value in H2O was lower than in D2O at 3% salt concentration.	Water	78-81	lysozyme	Homo sapiens	0-8
9491923-10	1998	Therefore, the effect of lysozyme concentration on the aggregation process in H2O may be smaller than in D2O.	Water	78-81	lysozyme	Homo sapiens	25-33
9496709-2	1998	AVP regulates the water channel (aquaporin-2:AQP2) through V2 receptors and increases the water permeability of the collecting duct.	Water	18-23	arginine vasopressin	Rattus norvegicus	0-3
9496709-2	1998	AVP regulates the water channel (aquaporin-2:AQP2) through V2 receptors and increases the water permeability of the collecting duct.	Water	90-95	arginine vasopressin	Rattus norvegicus	0-3
9501505-2	1998	When an animal explores an environment such as the water maze, the combination of place fields and correlational (Hebbian) long-term potentiation produces a weight matrix in the CA3 recurrent collaterals such that cells with overlapping place fields are more strongly interconnected than cells with nonoverlapping fields.	Water	51-56	carbonic anhydrase 3	Homo sapiens	178-181
9483507-5	1998	However, the Y2 receptor expression and arginine-8-vasopressin content declined, showing that the neuropeptide Y system is dynamic and suggesting that it plays a physiological role in salt and water homeostasis.	Water	193-198	neuropeptide Y	Rattus norvegicus	98-112
9437747-5	1998	injection of the TK agonist neuropeptide gamma (NP gamma), 31-250 ng/rat, markedly inhibited AngII-induced water intake.	Water	107-112	angiotensinogen	Rattus norvegicus	93-98
9437750-0	1998	Intracerebroventricular angiotensin II increases intraoral intake of water in rats.	Water	69-74	angiotensinogen	Rattus norvegicus	24-38
9437750-2	1998	Central angiotensin II increases ad lib intake from water bottles, but its effect on intraoral intake has not been examined.	Water	52-57	angiotensinogen	Rattus norvegicus	8-22
9437750-6	1998	Angiotensin II increased intraoral intake and increased ad lib water intake from bottles after the intraoral test.	Water	63-68	angiotensinogen	Rattus norvegicus	0-14
9437750-6	1998	Angiotensin II increased intraoral intake and increased ad lib water intake from bottles after the intraoral test.	Water	63-68	leucine rich repeat containing 15	Rattus norvegicus	59-62
9437750-7	1998	Thus angiotensin II increases water intake during both appetitive and consummatory phases of drinking.	Water	30-35	angiotensinogen	Rattus norvegicus	5-19
9443338-3	1998	The most conspicuous example is the water channel present in the specificity pocket of trypsin and thrombin.	Water	36-41	coagulation factor II, thrombin	Homo sapiens	99-107
9443338-4	1998	In thrombin, other vitamin K-dependent proteases, and some complement factors, Na+ binds in this water channel and enhances allosterically the catalytic activity of the enzyme, whereas digestive and fibrinolytic proteases are devoid of such regulation.	Water	97-102	coagulation factor II, thrombin	Homo sapiens	3-11
9520346-4	1998	A control group was given tap water (&lt; 0.001 mg U/L).	Water	30-35	nuclear RNA export factor 1	Rattus norvegicus	26-29
9453414-0	1998	The expression of water channels AQP1 and AQP2 in a large series of ADPKD kidneys.	Water	18-23	aquaporin 1 (Colton blood group)	Homo sapiens	33-37
9623527-1	1998	Exposure to the trace elements and micropollutions of tap water may be very considerable in dialysis patients.	Water	58-63	SEC14 like lipid binding 2	Homo sapiens	54-57
9623527-3	1998	NO3- and SO4(2-) were somewhat elevated in our tap water (22.2+/-7.6 and 21.8+/-11.3 mg/l) but decreased (P&lt;0.001) after 2RO (1.4+/-1.5 and 0.9+/-1.1 mg/l); the other anions, which were at a very low level, remained unchanged.	Water	51-56	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
9623527-3	1998	NO3- and SO4(2-) were somewhat elevated in our tap water (22.2+/-7.6 and 21.8+/-11.3 mg/l) but decreased (P&lt;0.001) after 2RO (1.4+/-1.5 and 0.9+/-1.1 mg/l); the other anions, which were at a very low level, remained unchanged.	Water	51-56	SEC14 like lipid binding 2	Homo sapiens	47-50
9648123-1	1998	Chronic schizophrenic patients are reported to develop imbalanced water homeostasis by the pathological secretion of vasopressin and aldosterone.	Water	66-71	arginine vasopressin	Homo sapiens	117-128
9769711-10	1998	Recent in vitro data suggest that the CaR directly regulates renal water handling in the collecting duct.	Water	67-72	calcium sensing receptor	Homo sapiens	38-41
9769711-11	1998	Indeed, patients with FHH concentrate their urine normally, despite their hypercalcemia, while those with autosomal dominant hypocalcemia can exhibit impaired urinary concentration at normal or even low Ca2+o, suggesting that the CaR enables coordination of renal calcium and water handling.	Water	276-281	calcium sensing receptor	Homo sapiens	230-233
9499589-3	1998	Two-dimensional protein arrays of ferritin and catalase, prepared at air/water interface and transferred onto silicon wafer, could be imaged both in air and in water by AFM using this sharp EBD-tip in contact mode.	Water	73-78	catalase	Homo sapiens	47-55
9499589-3	1998	Two-dimensional protein arrays of ferritin and catalase, prepared at air/water interface and transferred onto silicon wafer, could be imaged both in air and in water by AFM using this sharp EBD-tip in contact mode.	Water	160-165	catalase	Homo sapiens	47-55
9398305-1	1997	Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site.	Water	211-216	carbonic anhydrase 3	Homo sapiens	95-117
9496640-0	1997	Biogeochemical assessment of natural attenuation of JP-4-contaminated ground water in the presence of fluorinated surfactants.	Water	77-82	junctophilin 4	Homo sapiens	52-56
9398305-1	1997	Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site.	Water	211-216	carbonic anhydrase 3	Homo sapiens	119-125
9462893-8	1997	with either 25 or 100 microg nifedipine, followed by 25 pmol Ang II, drank significantly less water than controls during the first 15 min after infusion.	Water	94-99	angiotensinogen	Rattus norvegicus	61-67
9502583-4	1997	This ELISA used an IgG fraction of a rabbit polyclonal anti-IgE antibody coupled to the carboxylated surface, which prior to coupling had been preactivated with a water soluble carbodiimide.	Water	163-168	immunoglobulin heavy constant epsilon	Homo sapiens	60-63
9398185-10	1997	This resonance shows a pH-independent exchange rate with water (kex = 3900 s-1 at 30 degrees C, Eact = 8.9 kcal/mol) which may reflect the dissociation of the TIM-PGH complex, and meets the criteria for a low-barrier hydrogen bond on the basis of the significant downfield shift of 6.2 ppm from the NOH proton of the model compound acetohydroxamic acid, and a very low fractionation factor phi = 0.38 +/- 0.06.	Water	57-62	triosephosphate isomerase 1	Homo sapiens	159-162
9398185-4	1997	In the TIM-PGH complex, His-95 N epsilon H shows a slow, pH-independent exchange rate with water (kex = 80 s-1 at 30 degrees C, Eact = 19 kcal/mol), which is 44-fold slower than that of an exposed histidine suggesting partial shielding from bulk solvent, and a fractionation factor phi = 0.71 +/- 0.02 consistent with its donation of a normal hydrogen bond.	Water	91-96	triosephosphate isomerase 1	Homo sapiens	7-10
9435667-1	1997	The aim of this study was to investigate the effects of the antidiuretic hormone arginine vasopressin (AVP), which is released in vivo during dehydration and hypovolemia to prevent further water loss, on the activity of neurons in the subfornical organ (SFO).	Water	189-194	arginine vasopressin	Rattus norvegicus	90-101
9435667-1	1997	The aim of this study was to investigate the effects of the antidiuretic hormone arginine vasopressin (AVP), which is released in vivo during dehydration and hypovolemia to prevent further water loss, on the activity of neurons in the subfornical organ (SFO).	Water	189-194	arginine vasopressin	Rattus norvegicus	103-106
9435667-2	1997	The SFO is a brain structure with an open blood-brain barrier and is critically involved in angiotensin II (ANG II)-dependent water intake.	Water	126-131	angiotensinogen	Rattus norvegicus	92-106
9435667-2	1997	The SFO is a brain structure with an open blood-brain barrier and is critically involved in angiotensin II (ANG II)-dependent water intake.	Water	126-131	angiotensinogen	Rattus norvegicus	108-114
9371692-1	1997	In this work, we determined the effects of sphingosine 1-phosphate (S1P) on phospholipase D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn), and evaluated the effects of the water-soluble product ethanolamine on S1P-induced DNA synthesis in NIH 3T3 cells.	Water	189-194	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	93-96
9494194-12	1997	The PURR curvature diminished from 0.27416 to 0.15964 cms H2O (ml/sec2) (p &lt; 0.01).	Water	58-61	fucosyltransferase 2	Homo sapiens	66-70
9474757-1	1997	Enthalpy changes on the immersion of human serum albumin (HSA) into n-butanol, n-propanol, ethanol and methanol containing different amounts of water have been measured calorimetrically at 25 degrees C. Water sorption isotherms on HSA were also determined in water-n-butanol and water-ethanol mixtures.	Water	259-264	albumin	Homo sapiens	43-56
9474757-1	1997	Enthalpy changes on the immersion of human serum albumin (HSA) into n-butanol, n-propanol, ethanol and methanol containing different amounts of water have been measured calorimetrically at 25 degrees C. Water sorption isotherms on HSA were also determined in water-n-butanol and water-ethanol mixtures.	Water	259-264	albumin	Homo sapiens	43-56
9428674-0	1997	A central role for water in the control of the spin state of cytochrome P-450scc.	Water	19-24	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	61-80
9421280-4	1997	In a rodent model of acute thermal nociception, the mouse tail immersion test, Dex, in wild type (WT) control animals, produced a dose-dependent increase in the threshold for tail withdrawal from a 52 degrees C water bath with mean ED50 values of 99.9+/-14.5 (alpha2A), 94.6+/-17.8 (alpha2B) and 116.0/-17.1 (alpha2C) microg kg(-1), i.p.	Water	211-216	adrenergic receptor, alpha 2a	Mus musculus	260-267
9384586-8	1997	The observed water network might acount for differences in binding specificity between NF-kappaB p52 and NF-kappaB p50 homodimers.	Water	13-18	nuclear factor kappa B subunit 1	Homo sapiens	87-96
9384586-8	1997	The observed water network might acount for differences in binding specificity between NF-kappaB p52 and NF-kappaB p50 homodimers.	Water	13-18	nuclear factor kappa B subunit 2	Homo sapiens	97-100
9384586-8	1997	The observed water network might acount for differences in binding specificity between NF-kappaB p52 and NF-kappaB p50 homodimers.	Water	13-18	nuclear factor kappa B subunit 1	Homo sapiens	105-118
9532514-2	1997	Blocking this enzymatic cascade has been the focus of considerable research to the extent that the renin-angiotensin system is implicated in the control of blood pressure, sodium and water homeostasis, and cardiovascular function and structure.	Water	183-188	renin	Homo sapiens	99-104
9400022-10	1997	Interestingly, OTA-induced long-term activation of ERK1/2 in MDCK-C7 cells was associated with epithelial dedifferentiation, as assessed by analysis of vectorial solute and water transport as well as cell morphology.	Water	173-178	mitogen-activated protein kinase 1	Canis lupus familiaris	51-57
9473738-5	1997	ESR spin trapping with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) showed hydroxy radical (OH) generation in the reaction of H2O2 with either Cu,Zn-SOD or ceruloplasmin.	Water	70-85	superoxide dismutase 1	Homo sapiens	138-147
9423146-4	1997	Because of its low solubility in water and aqueous ethanol solution, zinc insulin was dissolved in 10% acetic acid-water solution for eye devices preparation.	Water	33-38	insulin	Homo sapiens	74-81
9423146-4	1997	Because of its low solubility in water and aqueous ethanol solution, zinc insulin was dissolved in 10% acetic acid-water solution for eye devices preparation.	Water	115-120	insulin	Homo sapiens	74-81
9374520-1	1997	A new water channel (aquaporin-8, gene symbol AQP8) was isolated from rat pancreas and liver by homology cloning.	Water	6-11	aquaporin 8	Rattus norvegicus	21-32
9374520-1	1997	A new water channel (aquaporin-8, gene symbol AQP8) was isolated from rat pancreas and liver by homology cloning.	Water	6-11	aquaporin 8	Rattus norvegicus	46-50
9369468-5	1997	When AQP3 was expressed in Xenopus oocytes, incubation with 0.3 mM HgCl2 decreased its osmotic water permability (Pf) by approximately 30%.	Water	95-100	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	5-9
9369468-15	1997	These results suggest that the structure of the aqueous pore of AQP3 resembles those of AQP1 and AQP2 and support the hypothesis that water and small molecules share a common pore in AQP3.	Water	134-139	aquaporin 1 (Colton blood group)	Homo sapiens	88-92
9428661-1	1997	The phospholipase A2 (PLA2) catalyzed synthesis and hydrolysis of phosphatidylcholine (PC) was studied in a water activity controlled organic medium.	Water	108-113	phospholipase A2 group IB	Homo sapiens	4-20
9428661-1	1997	The phospholipase A2 (PLA2) catalyzed synthesis and hydrolysis of phosphatidylcholine (PC) was studied in a water activity controlled organic medium.	Water	108-113	phospholipase A2 group IB	Homo sapiens	22-26
9428661-9	1997	Studies on PLA2 at water activity controlled conditions resulted in a more complete understanding of the enzymatic reaction and allowed to find the conditions most favorable for the synthetic reaction.	Water	19-24	phospholipase A2 group IB	Homo sapiens	11-15
9354635-2	1997	ApoA-I(142-187) is mainly unstructured in water but helical in SDS or dodecylphosphocholine (DPC), although the peptide only associates with DPC at approximately the critical micellar concentration.	Water	42-47	apolipoprotein A1	Homo sapiens	0-6
9425633-0	1997	Purification and functional reconstitution of the human CHIP28 water channel expressed in Saccharomyces cerevisiae.	Water	63-68	aquaporin 1 (Colton blood group)	Homo sapiens	56-62
9425633-1	1997	The yeast Saccharomyces cerevisiae was used for heterologous expression of the human CHIP28 water Aquaporin-1 channel (Aquaporin-1).	Water	92-97	aquaporin 1 (Colton blood group)	Homo sapiens	85-91
9425633-1	1997	The yeast Saccharomyces cerevisiae was used for heterologous expression of the human CHIP28 water Aquaporin-1 channel (Aquaporin-1).	Water	92-97	aquaporin 1 (Colton blood group)	Homo sapiens	98-109
9425633-1	1997	The yeast Saccharomyces cerevisiae was used for heterologous expression of the human CHIP28 water Aquaporin-1 channel (Aquaporin-1).	Water	92-97	aquaporin 1 (Colton blood group)	Homo sapiens	119-130
9374641-1	1997	The aquaporin-1 (AQP1) water channel protein is expressed in multiple mammalian tissues by several different developmental programs; however, the genetic regulation is undefined.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	4-15
9394482-4	1997	Industrial pollutants such as PCB-compounds and heavy metals, but also the use of large quantities of pesticides to control parasites and weeds have accumulated not only in water, but also in soil and have been deposited over large areas by atmospheric transport to enter the food chain leading to humans.	Water	173-178	pyruvate carboxylase	Homo sapiens	30-33
9374641-1	1997	The aquaporin-1 (AQP1) water channel protein is expressed in multiple mammalian tissues by several different developmental programs; however, the genetic regulation is undefined.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	17-21
9374816-13	1997	The less efficient sodium excretion occurring at low V is probably due to the influence of vasopressin on water, urea, and sodium movements across the collecting ducts.	Water	106-111	arginine vasopressin	Homo sapiens	91-102
9391772-9	1997	While the mechanism(s) remain speculative, salt and water retention through several factors operating in parallel, coupled with increased total peripheral vascular resistance, via increased renal endothelin-1 synthesis, are potentially important.	Water	52-57	endothelin 1	Homo sapiens	196-208
9370429-3	1997	The initial globular domain (1-47) of apolipoprotein A-I was excluded from the model, which was hydrated with an 8-A shell of water molecules.	Water	126-131	apolipoprotein A1	Homo sapiens	38-56
9365934-0	1997	A structural rationale for the design of water soluble peptide-derived neurokinin-1 antagonists.	Water	41-46	tachykinin precursor 1	Homo sapiens	71-83
9463054-2	1997	In the 1960s, PCBs were found in soil and water, and research confirmed that some PCB congeners degrade very slowly in the environment and can build up in the food chain.	Water	42-47	pyruvate carboxylase	Homo sapiens	14-17
9467970-0	1997	Solution structure determination of endothelin-1 in methanol/water by NMR and molecular modelling methods.	Water	61-66	endothelin 1	Homo sapiens	36-48
9467970-1	1997	To understand the structural requirements for the biological activity of endothelin peptides and to develop receptor selective endothelin analogues further, the solution structure of the bicyclic 21 amino acid residue vasoactive peptide, endothelin-1, has been determined in methanol-d3/water using high-resolution 1H-NMR spectroscopy.	Water	287-292	endothelin 1	Homo sapiens	238-250
9406916-1	1997	The role of centrally synthesised angiotensinogen in neural mechanisms subserving water drinking in rats was investigated by injecting antisense oligonucleotides complementary to rat angiotensinogen mRNA into the brain with the aim of inhibiting cerebral angiotensinogen synthesis.	Water	82-87	angiotensinogen	Rattus norvegicus	34-49
9404963-2	1997	Liver cirrhosis was induced by administering carbon tetrachloride (CCl4) in water solution to male Wistar rats.	Water	76-81	C-C motif chemokine ligand 4	Rattus norvegicus	67-71
9360608-4	1997	The iron binding site of hFBP incorporates a water and an exogenous phosphate ion as iron ligands and exhibits nearly ideal octahedral metal coordination.	Water	45-50	ECB2	Homo sapiens	25-29
9359399-6	1997	In this study we have examined the HSF DNA-binding activity in HeLa cells maintained in the sorbitol/water binary solution over a wide concentration range (0.1-0.9 M) and in Dulbecco"s medium supplemented with sorbitol or NaCl.	Water	101-106	interleukin 6	Homo sapiens	35-38
9335575-8	1997	Binding of native cytochrome c in water (NW) to DOPS vesicles is driven by the electrostatic interaction between positively charged residues in the protein and the negatively charged lipid headgroups on the membrane surface.	Water	34-39	cytochrome c, somatic	Homo sapiens	18-30
11671822-1	1997	The "ligandless" palladium acetate-catalyzed Suzuki cross-coupling reaction of ArX with aryl- and vinylboronic acids in water without organic cosolvent in the presence of tetrabutylammonium bromide is reported.	Water	120-125	aristaless related homeobox	Homo sapiens	79-82
9341907-2	1997	PC and 1,8-octanediol were conjugated by transesterification reaction of Streptomyces phospholipase D (PLD) under a water-chloroform biphasic system to afford phosphatidyloctanol, which was condensed with a protected 2-chloro-2-deoxyneuraminic acid derivative by using silver trifluoromethanesulfonate as an activator in chloroform and converted, after deprotection, to SPL.	Water	116-121	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	86-101
9341907-2	1997	PC and 1,8-octanediol were conjugated by transesterification reaction of Streptomyces phospholipase D (PLD) under a water-chloroform biphasic system to afford phosphatidyloctanol, which was condensed with a protected 2-chloro-2-deoxyneuraminic acid derivative by using silver trifluoromethanesulfonate as an activator in chloroform and converted, after deprotection, to SPL.	Water	116-121	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	103-106
9322478-9	1997	IMPLICATIONS: Continuous intravenous infusion of atrial natriuretic peptide, 0.1 microgram.kg-1.min-1, during gastrectomy was associated with higher water and sodium excretion and lower arterial blood pressure.	Water	149-154	natriuretic peptide A	Homo sapiens	49-75
9362293-1	1997	Previous studies indicate that rats with lesions centered on the area postrema (AP) drink more saline and consume abnormally large amounts of water after treatment with subcutaneous isoproterenol (Iso) angiotensin II.	Water	142-147	angiotensinogen	Rattus norvegicus	202-216
9302264-0	1997	Identification and characterization of aquaporin-2 water channel mutations causing nephrogenic diabetes insipidus with partial vasopressin response.	Water	51-56	arginine vasopressin	Homo sapiens	127-138
9324955-4	1997	However, when the water-soluble bisulfite addition product of menadione was used as the electron acceptor, an artifactual activity for DT-diaphorase was detected in these cell lines.	Water	18-23	NAD(P)H quinone dehydrogenase 1	Homo sapiens	135-148
9367582-0	1997	Surface and Spectroscopic Properties of Acetylcholinesterase Monolayer at the Air/Water Interface The behavior of the enzyme acetylcholinesterase was studied at the air/water interface.	Water	82-87	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-60
9594425-1	1997	Extent of water vapour adsorption (n1) of gelatin and bovine serum albumin and their mixtures in different proportion respectively has been measured by isopiestic vapour pressure methods at various values of water activity (a1) ranging between zero and unity.	Water	10-15	albumin	Homo sapiens	61-74
9367582-0	1997	Surface and Spectroscopic Properties of Acetylcholinesterase Monolayer at the Air/Water Interface The behavior of the enzyme acetylcholinesterase was studied at the air/water interface.	Water	169-174	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-60
9367582-0	1997	Surface and Spectroscopic Properties of Acetylcholinesterase Monolayer at the Air/Water Interface The behavior of the enzyme acetylcholinesterase was studied at the air/water interface.	Water	169-174	acetylcholinesterase (Cartwright blood group)	Homo sapiens	125-145
9367582-5	1997	The long-term stability of acetylcholinesterase at the air/water interface was demonstrated for pH 6.5 and a salt concentration of 10(-2) M (KCl).	Water	59-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	27-47
9413005-2	1997	There are several hypotheses to explain ACTH-induced brain shrinkage: 1) a catabolic effect of ACTH on brain tissue, 2) a mineralocorticoid effect resulting in a loss of water and 3) an increase in cerebrospinal fluid (CSF) pressure compressing the brain.	Water	170-175	proopiomelanocortin	Homo sapiens	40-44
9338654-3	1997	METHODS: Excretion rates of sodium and water were correlated with the excretion of urodilatin and with circulating levels of atrial natriuretic factor, antidiuretic hormone, aldosterone, and plasma renin activity during a period of 16 hours in 12 patients having had coronary artery bypass operations and with approximately a 400% elevation in levels of atrial natriuretic factor.	Water	39-44	renin	Homo sapiens	198-203
9284075-7	1997	Performance in the Morris water maze, which tests spatial memory, showed a marked learning deficit of the apolipoprotein E-deficient mice when compared with injured controls, which was apparent for at least 40 days.	Water	26-31	apolipoprotein E	Mus musculus	106-122
9505242-6	1997	After heating soymilk in a water-bath for 15 min at 75 and 100 degrees C, TI activity decreased to 35 and 12%, respectively.	Water	27-32	kunitz trypsin protease inhibitor	Glycine max	74-76
9360150-10	1997	With cuprophan, instead the reduced SOD/catalase ratio causes a greater H2O2 generation and a lower conversion to water.	Water	114-119	superoxide dismutase 1	Homo sapiens	36-39
9299519-1	1997	Aquaporin 1 (AQP1), a six-transmembrane domain protein that functions as a water channel, is present in many fluid secreting and absorbing tissues such as kidney, brain, heart, and eye.	Water	75-80	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
9299519-1	1997	Aquaporin 1 (AQP1), a six-transmembrane domain protein that functions as a water channel, is present in many fluid secreting and absorbing tissues such as kidney, brain, heart, and eye.	Water	75-80	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
9299519-2	1997	It is believed that among the five known mammalian aquaporins, kidney aquaporin (AQP2) is the only water channel that is regulated by arginine vasopressin (AVP).	Water	99-104	arginine vasopressin	Homo sapiens	143-154
9299519-5	1997	In addition, our data reveal that atrial natriuretic peptide (ANP), a peptide hormone that plays an important role in the regulation of body fluid homeostasis, blocks the AQP1-mediated increase in water permeability.	Water	197-202	natriuretic peptide A	Homo sapiens	34-60
9299519-5	1997	In addition, our data reveal that atrial natriuretic peptide (ANP), a peptide hormone that plays an important role in the regulation of body fluid homeostasis, blocks the AQP1-mediated increase in water permeability.	Water	197-202	natriuretic peptide A	Homo sapiens	62-65
9299519-5	1997	In addition, our data reveal that atrial natriuretic peptide (ANP), a peptide hormone that plays an important role in the regulation of body fluid homeostasis, blocks the AQP1-mediated increase in water permeability.	Water	197-202	aquaporin 1 (Colton blood group)	Homo sapiens	171-175
9299519-6	1997	Incubation with 8-bromo-cAMP or direct 8-bromo-cAMP injection into oocytes expressing AQP1 cRNA significantly increased membrane permeability to water, suggesting that stimulation of AQP1 activity by AVP may involve a cAMP-dependent mechanism.	Water	145-150	aquaporin 1 (Colton blood group)	Homo sapiens	86-90
9299519-6	1997	Incubation with 8-bromo-cAMP or direct 8-bromo-cAMP injection into oocytes expressing AQP1 cRNA significantly increased membrane permeability to water, suggesting that stimulation of AQP1 activity by AVP may involve a cAMP-dependent mechanism.	Water	145-150	aquaporin 1 (Colton blood group)	Homo sapiens	183-187
9299519-7	1997	Regulation of water permeability by AVP and ANP has potential relevance to active water transport in a variety of tissues that express AQP1 including kidney, brain, and eye.	Water	14-19	natriuretic peptide A	Homo sapiens	44-47
9299519-7	1997	Regulation of water permeability by AVP and ANP has potential relevance to active water transport in a variety of tissues that express AQP1 including kidney, brain, and eye.	Water	14-19	aquaporin 1 (Colton blood group)	Homo sapiens	135-139
9299519-7	1997	Regulation of water permeability by AVP and ANP has potential relevance to active water transport in a variety of tissues that express AQP1 including kidney, brain, and eye.	Water	82-87	natriuretic peptide A	Homo sapiens	44-47
9299519-7	1997	Regulation of water permeability by AVP and ANP has potential relevance to active water transport in a variety of tissues that express AQP1 including kidney, brain, and eye.	Water	82-87	aquaporin 1 (Colton blood group)	Homo sapiens	135-139
9299328-3	1997	We have applied labeling pulses in H2O to the deuterated GroEL-CypA-complex.	Water	35-38	GroEL	Escherichia coli	57-62
9337079-6	1997	This effect was attributed to taurine depletion since maintenance of the taurine-depleted rats on tap water for 2 days to remove the effects of beta-alanine yielded the same pattern as the taurine-depleted rats exposed to beta-alanine at the time of the experiment.	Water	102-107	nuclear RNA export factor 1	Rattus norvegicus	98-101
9284304-0	1997	Molecular dynamics study of water and Na+ ions in models of the pore region of the nicotinic acetylcholine receptor.	Water	28-33	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	83-115
9404730-6	1997	Control administrations of water and saline also evoked elevation in plasma CCK-LI, but the responses were so transient that amino acid effects were not obscured.	Water	27-32	cholecystokinin	Felis catus	76-79
9404730-8	1997	Cholecystokinin-8, 33 and 58 were among the CCK molecular forms identified by HPLC in plasma after administrations of phenylalanine and water.	Water	136-141	cholecystokinin	Felis catus	0-15
9404730-8	1997	Cholecystokinin-8, 33 and 58 were among the CCK molecular forms identified by HPLC in plasma after administrations of phenylalanine and water.	Water	136-141	cholecystokinin	Felis catus	44-47
9312012-3	1997	Here, we present the neutron structure of the activated lipase-colipase-micelle complex as determined using the D2O/H2O contrast variation low resolution diffraction method.	Water	116-119	colipase	Homo sapiens	63-71
9360150-10	1997	With cuprophan, instead the reduced SOD/catalase ratio causes a greater H2O2 generation and a lower conversion to water.	Water	114-119	catalase	Homo sapiens	40-48
9327205-2	1997	Vasopressin is inappropriately elevated in the majority of patients with hyponatremia and causes free water retention by stimulating V2-receptors in the collecting ducts.	Water	102-107	arginine vasopressin	Homo sapiens	0-11
9334989-4	1997	ANG II (10 pmol) injection into the MnPO of sham-lesioned rats induced water and sodium intake and pressor responses.	Water	71-76	angiotensinogen	Rattus norvegicus	0-6
9334989-5	1997	VMH-lesion reduced ANG II-induced water intake and increased saline intake.	Water	34-39	angiotensinogen	Rattus norvegicus	19-25
9334989-6	1997	In sham rats phenylephrine (80 nmol) into MnPO increased, whereas norepinephrine (80 nmol) and clonidine (40 nmol) reduced ANG II-induced water intake while sodium intake was reduced only by clonidine into MnPO.	Water	138-143	angiotensinogen	Rattus norvegicus	123-129
9311665-1	1997	The endocrine and neural peptide, peptide YY, inhibits intestinal secretion of water and electrolytes in several animal species and in man.	Water	79-84	peptide YY	Homo sapiens	34-44
9306136-1	1997	Aluminum is present in tap water, antiperspirants and cosmetics up to 20%.	Water	27-32	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	23-26
9323711-12	1997	CONCLUSIONS: Our finding that aquaporin-1 mRNA is reproducibly induced in lung following CPB/HCA with 6 hr of reperfusion suggests an important role for the water channel in the setting of pulmonary edema.	Water	157-162	aquaporin 1 (Colton blood group)	Homo sapiens	30-41
9288180-1	1997	BACKGROUND: Antioxidant enzymes (AEs), which catalyze the conversion of reactive oxygen species (ROS) to water, include catalase (CAT), manganese-containing superoxide dismutase (MnSOD), and copper and zinc-containing superoxide dismutase (CuZnSOD).	Water	105-110	catalase	Homo sapiens	130-133
9314187-4	1997	Moreover IK-1 and, to a lesser extent IK-2, reduced the lipid peroxidation induced in the microsomes by the water-soluble azo-initiator 2,2"-Azobis (2-methylpropionamidine) dihydrochloride (AMPH), indicating the IK-1 and IK-2 ability as chain-breaking antioxidants.	Water	108-113	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	9-13
9338132-0	1997	Improper fuse in ICS Medical NCI-480 water caloric stimulator.	Water	37-42	Polykaryocytosis inducer	Homo sapiens	9-13
9288180-1	1997	BACKGROUND: Antioxidant enzymes (AEs), which catalyze the conversion of reactive oxygen species (ROS) to water, include catalase (CAT), manganese-containing superoxide dismutase (MnSOD), and copper and zinc-containing superoxide dismutase (CuZnSOD).	Water	105-110	catalase	Homo sapiens	120-128
9311665-3	1997	The aim of the present study was to investigate the mechanisms of the peptide YY effect on vasoactive intestinal peptide (VIP)-stimulated jejunal net water flux in the rat.	Water	150-155	vasoactive intestinal peptide	Rattus norvegicus	122-125
9311665-5	1997	A small peptide YY dose (10 pmol/kg) inhibited significantly (P &lt; 0.005) the jejunal net water flux produced by 30 microg/kg per h of VIP.	Water	92-97	vasoactive intestinal peptide	Rattus norvegicus	137-140
9264547-8	1997	Analysis of kinetic and dissociation constants proves the mechanism of barley chitinase is consistent with a Bi-Bi kinetic model for hydrolysis, with (GlcNAc)4 and water as substrates and (GlcNAc)2 as products.	Water	164-169	Chi	Hordeum vulgare	78-87
9311665-7	1997	These results suggest that peptide YY inhibits VIP-stimulated jejunal net water flux in vivo through a neural mechanism implicating the participation of nicotinic synapses, alpha2-adrenoceptors and sigma receptors.	Water	74-79	vasoactive intestinal peptide	Rattus norvegicus	47-50
9301120-0	1997	Long-term effects of water-soluble corn bran hemicellulose on glucose tolerance in obese and non-obese patients: improved insulin sensitivity and glucose metabolism in obese subjects.	Water	21-26	insulin	Homo sapiens	122-129
21639331-3	1997	The background due to diffusion of water from the air was normally in the range 0.3-0.9 mug of water min(-1) depending on environmental humidity.	Water	35-40	CD59 molecule (CD59 blood group)	Homo sapiens	101-107
21639331-3	1997	The background due to diffusion of water from the air was normally in the range 0.3-0.9 mug of water min(-1) depending on environmental humidity.	Water	95-100	CD59 molecule (CD59 blood group)	Homo sapiens	101-107
9283697-19	1997	In contrast, the more selective iNOS inhibitor S-methyl-isothiourea (SMT) (10 micrograms ml-1) in drinking water) significantly reduced PMNs and lymphocyte influx in the sponge having no effect on monocyte influx.	Water	107-112	nitric oxide synthase 2	Rattus norvegicus	32-36
9261056-1	1997	Vasopressin regulates water excretion from the kidney by increasing the osmotic water permeability of the renal collecting duct.	Water	22-27	arginine vasopressin	Homo sapiens	0-11
9468598-10	1997	It is assumed that the water channel recruitment mechanism, found for vasopressin acting on the collecting duct principal cells in mammals, is also involved when vasotocin and hydrins stimulate their hydroosmotic target cells and that hormone-regulated aquaporin 2-like proteins could be identified in the three osmoregulatory organs of amphibians.	Water	23-28	arginine vasopressin	Homo sapiens	70-81
9468604-1	1997	It is well known that arginine vasopressin (AVP) produces up to a 40-fold increase (0.1 to 4.0 microL/min.cm2) in net water flux across the amphibian urinary bladder under an osmotic gradient (mucosal side 10% hypotonic).	Water	118-123	arginine vasopressin	Homo sapiens	31-42
9468604-1	1997	It is well known that arginine vasopressin (AVP) produces up to a 40-fold increase (0.1 to 4.0 microL/min.cm2) in net water flux across the amphibian urinary bladder under an osmotic gradient (mucosal side 10% hypotonic).	Water	118-123	arginine vasopressin	Homo sapiens	44-47
9261056-1	1997	Vasopressin regulates water excretion from the kidney by increasing the osmotic water permeability of the renal collecting duct.	Water	80-85	arginine vasopressin	Homo sapiens	0-11
9261056-2	1997	The aquaporin-2 water channel has been demonstrated to be the target for this action of vasopressin.	Water	16-21	arginine vasopressin	Homo sapiens	88-99
9272103-1	1997	The release of arginine vasopressin (AVP) and atrial natriuretic hormone (ANH) and their involvement in renal water and electrolyte metabolism in primary aldosteronism in humans were studied.	Water	110-115	arginine vasopressin	Homo sapiens	15-35
9272103-7	1997	After the operation, baseline plasma AVP was normal and decreased in response to the decrease in Posm after the water load, with normal urinary dilution and diuresis.	Water	112-117	arginine vasopressin	Homo sapiens	37-40
15481764-10	1997	(2) The water load-induced inhibition of ADH secretion and stimulation of ANP secretion or ANP activity, more defective in the upright position than in the recumbent one, is probably another major contributing factor to orthostatic oedema.	Water	8-13	arginine vasopressin	Homo sapiens	41-44
9285248-0	1997	Study on the mechanism of immunopotentiating antitumor effect of 6-MPG, a water-soluble derivative of 6-mercaptopurine.	Water	74-79	N-methylpurine-DNA glycosylase	Mus musculus	67-70
9268566-0	1997	Tryptophan, Tryptophan-Leucine, and BSA Adsorption at an Oil-Water Interface Adsorption of the amino acid tryptophan, the peptide tryptophan-leucine and the protein bovine serum albumin (BSA) at buffered water-oleyl alcohol interfaces has been studied by ellipsometry.	Water	61-66	albumin	Homo sapiens	172-185
9301044-1	1997	The phosphorescence decay of bovine serum albumin in water-glycerol solutions at room temperature is analysed by the maximum entropy method.	Water	53-58	albumin	Homo sapiens	36-49
9260257-3	1997	We propose that the inappropriately high plasma level of ADH led to the inability to excrete sufficient amounts of free water during a hyperhydration protocol with a relatively hypotonic fluid, which resulted in acute hyponatremia and central nervous system involvement.	Water	120-125	arginine vasopressin	Homo sapiens	57-60
14759824-9	1997	Water vapor fluxes, derived from the sap flow method, lagged behind those derived by the branch bag method by 1 to 2 h. The sap flow method also suffered from sampling errors caused by the non-uniformity of flow across the sapwood and the spatial variability of sapwood cross section throughout the forest.	Water	0-5	SH2 domain containing 1A	Homo sapiens	37-40
9269868-1	1997	A long-acting depot formulation of recombinant human interferon-gamma (rhIFN-gamma) was achieved by microencapsulation of rhIFN-gamma in polylactic-coglycolic acid (PLGA) microspheres by a water-in-oil-in-water technique.	Water	189-194	interferon gamma	Homo sapiens	53-69
9269868-1	1997	A long-acting depot formulation of recombinant human interferon-gamma (rhIFN-gamma) was achieved by microencapsulation of rhIFN-gamma in polylactic-coglycolic acid (PLGA) microspheres by a water-in-oil-in-water technique.	Water	205-210	interferon gamma	Homo sapiens	53-69
9251973-1	1997	In this study, we investigated the participation of adrenergic receptors of the median preoptic area (MnPO) and the participation of ventromedial hypothalamus (VMH) in angiotensin II-(ANG II)-induced water intake and pressor responses.	Water	200-205	angiotensinogen	Rattus norvegicus	168-182
9251973-1	1997	In this study, we investigated the participation of adrenergic receptors of the median preoptic area (MnPO) and the participation of ventromedial hypothalamus (VMH) in angiotensin II-(ANG II)-induced water intake and pressor responses.	Water	200-205	angiotensinogen	Rattus norvegicus	184-190
9251973-4	1997	In VMH-lesioned rats ANG II-induced water intake increased with a previous injection of noradrenaline, phenylephrine, or isoproterenol.	Water	36-41	angiotensinogen	Rattus norvegicus	21-27
15481764-10	1997	(2) The water load-induced inhibition of ADH secretion and stimulation of ANP secretion or ANP activity, more defective in the upright position than in the recumbent one, is probably another major contributing factor to orthostatic oedema.	Water	8-13	natriuretic peptide A	Homo sapiens	74-77
15481764-10	1997	(2) The water load-induced inhibition of ADH secretion and stimulation of ANP secretion or ANP activity, more defective in the upright position than in the recumbent one, is probably another major contributing factor to orthostatic oedema.	Water	8-13	natriuretic peptide A	Homo sapiens	91-94
9201991-2	1997	Renin is a rate-limiting enzyme of the renin-angiotensin system that regulates blood pressure and water-electrolyte balance.	Water	98-103	renin	Homo sapiens	0-5
9240424-1	1997	Changes in gastric mucosal constitutive NO synthase (cNOS) and inducible NO synthase (iNOS) activities with the development of gastric mucosal lesions induced by water immersion restraint (WIR) stress were investigated in rats pretreated with and without NOS inhibitors.	Water	162-167	nitric oxide synthase 2	Rattus norvegicus	63-84
9240424-1	1997	Changes in gastric mucosal constitutive NO synthase (cNOS) and inducible NO synthase (iNOS) activities with the development of gastric mucosal lesions induced by water immersion restraint (WIR) stress were investigated in rats pretreated with and without NOS inhibitors.	Water	162-167	nitric oxide synthase 2	Rattus norvegicus	86-90
9201991-2	1997	Renin is a rate-limiting enzyme of the renin-angiotensin system that regulates blood pressure and water-electrolyte balance.	Water	98-103	renin	Homo sapiens	39-44
9201993-8	1997	Sap C increased the rate of hydrolysis of both the artificial water soluble substrate, 4-methylumbelliferyl-beta-D-glucopyranoside, and the lipid substrate, glucosylceramide, while Sap A only stimulated degradation of the sphingolipid.	Water	62-67	SH2 domain containing 1A	Homo sapiens	0-3
9252492-0	1997	Water deprivation upregulates ANG II AT1 binding and mRNA in rat subfornical organ and anterior pituitary.	Water	0-5	angiotensinogen	Rattus norvegicus	30-36
9247722-4	1997	The ESR parameters of 2 components agreed with those of probes dissolved in water and lipidic phases.	Water	76-81	esterase 5 regulator	Mus musculus	4-7
9274054-1	1997	Two thermophilic anaerobic bacterial consortia (ALK-1 and LLNL-1), capable of degrading the aromatic fuel hydrocarbons, benzene, toluene, ethylbenzene, and the xylenes (BTEX compounds), were developed at 60 degrees C from the produced water of ARCO"S Kuparuk oil field at Alaska and the subsurface water at the Lawrence Livermore National Laboratory gasoline-spill site, respectively.	Water	235-240	secretory leukocyte peptidase inhibitor	Homo sapiens	48-53
9274054-1	1997	Two thermophilic anaerobic bacterial consortia (ALK-1 and LLNL-1), capable of degrading the aromatic fuel hydrocarbons, benzene, toluene, ethylbenzene, and the xylenes (BTEX compounds), were developed at 60 degrees C from the produced water of ARCO"S Kuparuk oil field at Alaska and the subsurface water at the Lawrence Livermore National Laboratory gasoline-spill site, respectively.	Water	298-303	secretory leukocyte peptidase inhibitor	Homo sapiens	48-53
9274054-4	1997	Use of [ring-14C]toluene in the BTEX mixture incubated at 50 degrees C verified that 41% and 31% of the biodegraded toluene was metabolized within 14 days to water-soluble products by ALK-1 and LLNL-1, respectively.	Water	158-163	secretory leukocyte peptidase inhibitor	Homo sapiens	184-189
9248673-7	1997	In addition, an interaction between TGF and angiotensin II (AngII) seems to be essential to maintaining GFR despite large variations in daily intake of salt and water.	Water	161-166	angiotensinogen	Homo sapiens	44-58
9199811-1	1997	SP-C, a pulmonary surfactant-specific protein, aids the spreading of the main surfactant phospholipid L-alpha-dipalmitoylphosphatidylcholine (DPPC) across air/water interfaces, a process that has possible implications for in vivo function.	Water	159-164	surfactant protein C	Homo sapiens	0-4
9247770-2	1997	As a corollary, information would be gained about the role of centrally synthesised angiotensinogen in the neural mechanisms subserving water drinking in rats.	Water	136-141	angiotensinogen	Rattus norvegicus	84-99
9263686-2	1997	Aquaporin-2, "vasopressin-regulated water channel", is regulated by vasopressin in two ways to account for overall control of collecting duct water permeability.	Water	36-41	arginine vasopressin	Homo sapiens	14-25
9263686-2	1997	Aquaporin-2, "vasopressin-regulated water channel", is regulated by vasopressin in two ways to account for overall control of collecting duct water permeability.	Water	36-41	arginine vasopressin	Homo sapiens	68-79
9263686-3	1997	First, vasopressin has a short-term effect in triggering translocation of aquaporin-2-containing intracytoplasmic vesicles to the apical plasma membrane, thus increasing principal cell water permeability.	Water	185-190	arginine vasopressin	Homo sapiens	7-18
9263686-4	1997	Second, vasopressin has a long-term effect in increasing the abundance of aquaporin-2 in collecting duct principal cells, increasing the maximal attainable water permeability.	Water	156-161	arginine vasopressin	Homo sapiens	8-19
9219154-7	1997	The pressor response to intravenous injection of Big endothelin-1 (1 nmol/kg, intravenously) was inhibited by &gt; 50% in rats given A-127722 at 10 mg/kg per d, which confirms the efficacy of A-127722 in blocking ETA-mediated responses when placed in drinking water.	Water	260-265	endothelin 1	Rattus norvegicus	53-65
9333407-0	1997	[Water as a stabilizer and plasticizer of the globular structure of lysozyme].	Water	1-6	lysozyme	Homo sapiens	68-76
9812585-0	1997	[Studies of malignant transformation of human fetal lung cells induced by organic extract from tap water].	Water	99-104	USO1 vesicle transport factor	Homo sapiens	95-98
9252963-5	1997	When 1% NaCl was replaced with tap water, the survival time was prolonged by approximately 80%.	Water	35-40	nuclear RNA export factor 1	Rattus norvegicus	31-34
9247544-4	1997	We examined the expression of His1-3 at the RNA and protein levels and found that it is induced specifically by water stress.	Water	112-117	histone H1-3	Arabidopsis thaliana	30-36
9812585-1	1997	Expression of P53 protein was determined in the process and the end of induction of malignant transformation in human fetal lung cells, with organic extract from tap water in a river of City G, to study its molecular mechanism.	Water	166-171	tumor protein p53	Homo sapiens	14-17
9812585-1	1997	Expression of P53 protein was determined in the process and the end of induction of malignant transformation in human fetal lung cells, with organic extract from tap water in a river of City G, to study its molecular mechanism.	Water	166-171	USO1 vesicle transport factor	Homo sapiens	162-165
9177354-2	1997	The archetypal aquaporin AQP1 is a partly glycosylated water-selective channel that is widely expressed in the plasma membranes of several water-permeable epithelial and endothelial cells.	Water	55-60	aquaporin 1 (Colton blood group)	Homo sapiens	25-29
9224700-0	1997	Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer"s disease and Down"s syndrome brains.	Water	17-22	amyloid beta precursor protein	Homo sapiens	31-43
9224700-5	1997	Both pyroglutamate-modified peptides and the full-length A beta form a stable aggregate that is water soluble.	Water	96-101	amyloid beta precursor protein	Homo sapiens	57-63
9184137-4	1997	The C=NH stretching frequencies of rhodopsin, the green cone pigment, and the red cone pigment in H2O (D2O) are found at 1656 (1623), 1640 (1618), and 1644 cm(-1), respectively.	Water	98-101	rhodopsin	Homo sapiens	35-44
9169447-1	1997	The aquaporin-2 (AQP2) vasopressin water channel is translocated to the apical membrane upon vasopressin stimulation.	Water	35-40	vasopressin	Sus scrofa	23-34
9169447-1	1997	The aquaporin-2 (AQP2) vasopressin water channel is translocated to the apical membrane upon vasopressin stimulation.	Water	35-40	vasopressin	Sus scrofa	93-104
9177354-2	1997	The archetypal aquaporin AQP1 is a partly glycosylated water-selective channel that is widely expressed in the plasma membranes of several water-permeable epithelial and endothelial cells.	Water	139-144	aquaporin 1 (Colton blood group)	Homo sapiens	25-29
9255572-6	1997	It is this new, MXR-inhibiting property, unrecognized as yet, that classifies these chemicals among top-rank hazardous water pollutants.	Water	119-124	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	16-19
9219896-9	1997	(1) For apoA-I-complexes, the partition of cis-PA between water and lipid phase at temperatures below and above the transition temperature of DPPC (T(t)) was insensitive to Chol and temperature, while partition of trans-PA into the lipid phase of Chol-containing complex was increased at high temperature and decreased at low temperature.	Water	58-63	apolipoprotein A1	Homo sapiens	8-14
9284546-6	1997	The relationship between the orientation of cytochrome P450scc-adrenodoxin complex in monolayers on the water-air interface and the pressure produced at the interface at the moment of monolayer formation was found.	Water	104-109	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	44-62
9247028-1	1997	It has been shown that micro-injections of angiotensin II in the Organum cavum pre-lamina terminalis (OCPLT) of the rat brain trigger water intake.	Water	134-139	angiotensinogen	Rattus norvegicus	43-57
9194511-3	1997	The drinking water contained 10% glucose to prevent hypoglycemia in the insulin-injected rats.	Water	13-18	insulin	Homo sapiens	72-79
9227644-2	1997	Furthermore, the vasopressin-induced increase in apical membrane water permeability of renal principal cells is dependent on a rise in intracellular adenosine 3",5"-cyclic monophosphate and activation of protein kinase A (PKA).	Water	65-70	vasopressin	Sus scrofa	17-28
9189869-0	1997	Studies on the movement of water through the isolated toad bladder and its modification by vasopressin.	Water	27-32	arginine vasopressin	Homo sapiens	91-102
9189853-1	1997	Antidiuretic hormone leads to an increase in the permeability for water and urea in the inner medullary collecting duct.	Water	66-71	arginine vasopressin	Homo sapiens	0-20
9188045-5	1997	In amorphous solids at low water content (glassy state), the cyclic anhydride intermediate of insulin reacts predominantly with water to form deamidated insulin, whereas the intermolecular reaction with another insulin molecule to form a covalent dimer accounts for &lt; or = 15% of the total degradation.	Water	27-32	insulin	Homo sapiens	94-101
9241159-3	1997	Based on FTIR transmission spectra to describe the water structure of ionic solutions, in situ FTIR/internal reflection spectroscopy (FTIR/IRS) has been used to spectroscopically characterize interfacial water at fluoride salt surfaces.	Water	204-209	isoleucyl-tRNA synthetase 1	Homo sapiens	139-142
9188045-5	1997	In amorphous solids at low water content (glassy state), the cyclic anhydride intermediate of insulin reacts predominantly with water to form deamidated insulin, whereas the intermolecular reaction with another insulin molecule to form a covalent dimer accounts for &lt; or = 15% of the total degradation.	Water	128-133	insulin	Homo sapiens	153-160
9182817-7	1997	The production of TNF was paralleled by accumulation of skin water; this was partially prevented by intraperitoneal injection of antibody against murine TNF.	Water	61-66	tumor necrosis factor	Mus musculus	18-21
9182817-7	1997	The production of TNF was paralleled by accumulation of skin water; this was partially prevented by intraperitoneal injection of antibody against murine TNF.	Water	61-66	tumor necrosis factor	Mus musculus	153-156
9188045-6	1997	Increasing water content reduces the glass transition temperature of insulin to &lt; 35 degrees C, and covalent dimer formation becomes increasingly favored relative to deamidation.	Water	11-16	insulin	Homo sapiens	69-76
9188045-5	1997	In amorphous solids at low water content (glassy state), the cyclic anhydride intermediate of insulin reacts predominantly with water to form deamidated insulin, whereas the intermolecular reaction with another insulin molecule to form a covalent dimer accounts for &lt; or = 15% of the total degradation.	Water	128-133	insulin	Homo sapiens	94-101
9188045-9	1997	The kinetics and product distribution of human insulin in lyophilized powders between pH 3 and 5 illustrate the differential sensitivities of various solid-state reaction types to the effects of water activity and solid-phase behavior.	Water	195-200	insulin	Homo sapiens	47-54
9188045-5	1997	In amorphous solids at low water content (glassy state), the cyclic anhydride intermediate of insulin reacts predominantly with water to form deamidated insulin, whereas the intermolecular reaction with another insulin molecule to form a covalent dimer accounts for &lt; or = 15% of the total degradation.	Water	128-133	insulin	Homo sapiens	153-160
9174082-2	1997	Angiotensin II (1 mg/kg subcutaneously) caused significant increases in the 1-h intakes of water and 1.8% NaCl compared to controls, the effect on water intake being the greater.	Water	91-96	angiotensinogen	Rattus norvegicus	0-14
9174082-2	1997	Angiotensin II (1 mg/kg subcutaneously) caused significant increases in the 1-h intakes of water and 1.8% NaCl compared to controls, the effect on water intake being the greater.	Water	147-152	angiotensinogen	Rattus norvegicus	0-14
9187257-6	1997	In Xenopus laevis oocytes injected with the cRNA of hOCT1, the specific uptake of the organic cation 3H-1-methyl-4-phenylpyridinium (3H-MPP+) was significantly enhanced (8-fold) over that in water-injected oocytes.	Water	191-196	solute carrier family 22 member 1	Homo sapiens	52-57
9152098-11	1997	CONCLUSION: Psychotic exacerbations are associated with enhanced antidiuretic hormone secretion, for unknown reasons, in schizophrenic patients with hyponatremia and polydipsia, thereby placing them at increased risk of life-threatening water intoxication.	Water	237-242	arginine vasopressin	Homo sapiens	65-85
9174342-3	1997	With a view to gain insight into domain-domain interactions within this region, fragment C1r (gamma-B)2, obtained by autolytic proteolysis of the active protease, was cross-linked with the water-soluble reagent 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide.	Water	189-194	complement C1r	Homo sapiens	89-92
9174342-3	1997	With a view to gain insight into domain-domain interactions within this region, fragment C1r (gamma-B)2, obtained by autolytic proteolysis of the active protease, was cross-linked with the water-soluble reagent 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide.	Water	189-194	tryptophanyl-tRNA synthetase 1	Homo sapiens	94-103
9140566-7	1997	Oral water load caused Hgb, PCV, PTP, serum electrolyte and creatinine, SCOP, and urine osmolality values to remain unchanged or decrease slowly and pH, BE, HCO3-, FECa values to increase slightly by 180 minutes.	Water	5-10	lithostathine	Bos taurus	33-36
9194128-9	1997	It is the scatter in the replacement plug in the surface of the water phantom which was effectively ignored by previous workers, and which explains the underestimates of around 2% in PSF and TAR.	Water	64-69	insulin like growth factor binding protein 7	Homo sapiens	183-186
9176367-4	1997	DVR endothelium probably contains a "water-only" pathway most likely mediated by the aquaporin-1 (AQP1) water channel.	Water	37-42	aquaporin 1 (Colton blood group)	Homo sapiens	85-96
9176367-4	1997	DVR endothelium probably contains a "water-only" pathway most likely mediated by the aquaporin-1 (AQP1) water channel.	Water	37-42	aquaporin 1 (Colton blood group)	Homo sapiens	98-102
9176367-4	1997	DVR endothelium probably contains a "water-only" pathway most likely mediated by the aquaporin-1 (AQP1) water channel.	Water	104-109	aquaporin 1 (Colton blood group)	Homo sapiens	85-96
9176367-4	1997	DVR endothelium probably contains a "water-only" pathway most likely mediated by the aquaporin-1 (AQP1) water channel.	Water	104-109	aquaporin 1 (Colton blood group)	Homo sapiens	98-102
9176368-0	1997	Evidence that aquaporin-1 mediates NaCl-induced water flux across descending vasa recta.	Water	48-53	aquaporin 1 (Colton blood group)	Homo sapiens	14-25
9176368-7	1997	We conclude that OMDVR water flux driven by NaCl gradients is most likely mediated by the AQP1 water channel and that NaCl and urea gradients drive water efflux in vivo by this route.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	90-94
9176368-7	1997	We conclude that OMDVR water flux driven by NaCl gradients is most likely mediated by the AQP1 water channel and that NaCl and urea gradients drive water efflux in vivo by this route.	Water	95-100	aquaporin 1 (Colton blood group)	Homo sapiens	90-94
9176368-7	1997	We conclude that OMDVR water flux driven by NaCl gradients is most likely mediated by the AQP1 water channel and that NaCl and urea gradients drive water efflux in vivo by this route.	Water	95-100	aquaporin 1 (Colton blood group)	Homo sapiens	90-94
9136830-7	1997	Plasma PYY was correlated negatively (P &lt; 0.01) with net fluxes of water, Cl-, Na+, and K+.	Water	70-75	peptide YY	Homo sapiens	7-10
9125517-4	1997	A chemical catalytic mechanism of proteolysis consistent with the kinetic data is proposed, in which Tyr216-ArO-, in the course of being released from the active-site metal ion, deprotonates a water molecule attacking the Zn2+-activated substrate linkage, leading to a metal-coordinated tetrahedral oxyanion adduct that subsequently fragments.	Water	193-198	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	108-111
9198011-1	1997	Alkaline ionized water (AKW) produced by the electrolysis of tap water (TPW) was given to pregnant rats throughout gestation.	Water	17-22	nuclear RNA export factor 1	Rattus norvegicus	61-64
9198011-1	1997	Alkaline ionized water (AKW) produced by the electrolysis of tap water (TPW) was given to pregnant rats throughout gestation.	Water	65-70	nuclear RNA export factor 1	Rattus norvegicus	61-64
9140125-5	1997	Quantitation of aromatase activity by the [3H] water assay yielded values of 27.23 +/- 6.87 and 26.52 +/- 9.12 fmol/hr/mg of protein for BPH (nine patients) and PC (nine patients), respectively.	Water	47-52	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	16-25
9178136-7	1997	Water turnover rate of the cows was dependent on dry matter intake, milk yield, and respiratory-cutaneous water loss.	Water	0-5	Weaning weight-maternal milk	Bos taurus	68-72
9178136-8	1997	The milk-free water balance (water turnover rate minus water secreted in milk) could be very efficiently predicted for lactating and nonlactating cows by the following equation: milk-free water balance (kilograms per day) = digestible energy intake (megacalories per day) x 0.58 + respiratory-cutaneous loss (kilograms per day) x 0.97 (n = 18; R2 = 0.97).	Water	14-19	Weaning weight-maternal milk	Bos taurus	4-8
9178136-8	1997	The milk-free water balance (water turnover rate minus water secreted in milk) could be very efficiently predicted for lactating and nonlactating cows by the following equation: milk-free water balance (kilograms per day) = digestible energy intake (megacalories per day) x 0.58 + respiratory-cutaneous loss (kilograms per day) x 0.97 (n = 18; R2 = 0.97).	Water	14-19	Weaning weight-maternal milk	Bos taurus	73-77
9178136-8	1997	The milk-free water balance (water turnover rate minus water secreted in milk) could be very efficiently predicted for lactating and nonlactating cows by the following equation: milk-free water balance (kilograms per day) = digestible energy intake (megacalories per day) x 0.58 + respiratory-cutaneous loss (kilograms per day) x 0.97 (n = 18; R2 = 0.97).	Water	14-19	Weaning weight-maternal milk	Bos taurus	73-77
9178136-8	1997	The milk-free water balance (water turnover rate minus water secreted in milk) could be very efficiently predicted for lactating and nonlactating cows by the following equation: milk-free water balance (kilograms per day) = digestible energy intake (megacalories per day) x 0.58 + respiratory-cutaneous loss (kilograms per day) x 0.97 (n = 18; R2 = 0.97).	Water	29-34	Weaning weight-maternal milk	Bos taurus	4-8
9200142-3	1997	The G-Cd group was given Cd during pregnancy, but given tap water after birth.	Water	60-65	nuclear RNA export factor 1	Rattus norvegicus	56-59
18966796-2	1997	In the presence of the oxidant potassium iodate, BTASPAP reacts with Co(III), Ni(II), V(V) and Fe(III) to form stable, negatively charged, water-soluble chelates.	Water	139-144	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	69-76
18966796-2	1997	In the presence of the oxidant potassium iodate, BTASPAP reacts with Co(III), Ni(II), V(V) and Fe(III) to form stable, negatively charged, water-soluble chelates.	Water	139-144	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	72-75
9226398-9	1997	These findings demonstrate that somatostatin and octreotide modulate the release of nitric oxide, TNF, H2O be Kupffer cells depending on the concentration of hormones used.	Water	103-106	somatostatin	Rattus norvegicus	32-44
9109429-3	1997	A significant increase in urine volume in the water-loaded rats was observed by the second day of water loading, indicating onset of vasopressin escape.	Water	46-51	arginine vasopressin	Rattus norvegicus	133-144
9109429-3	1997	A significant increase in urine volume in the water-loaded rats was observed by the second day of water loading, indicating onset of vasopressin escape.	Water	98-103	arginine vasopressin	Rattus norvegicus	133-144
9109429-8	1997	The results suggest that escape from vasopressin-induced antidiuresis is attributable, at least in part, to a vasopressin-independent decrease in aquaporin-2 water channel expression in the renal collecting duct.	Water	158-163	arginine vasopressin	Rattus norvegicus	37-48
9109429-8	1997	The results suggest that escape from vasopressin-induced antidiuresis is attributable, at least in part, to a vasopressin-independent decrease in aquaporin-2 water channel expression in the renal collecting duct.	Water	158-163	arginine vasopressin	Rattus norvegicus	110-121
9251761-2	1997	These neurons act to inhibit water and salt intake by blocking the action of angiotensin II.	Water	29-34	angiotensinogen	Homo sapiens	77-91
9095083-6	1997	The renal cytolocalization of the Ang II/AVP receptor to the outer medullary thick ascending limb tubules and inner medullary collecting ducts is consistent with the well-established AVP stimulation of sodium and water reabsorption in these tubules.	Water	213-218	arginine vasopressin	Homo sapiens	41-44
9060369-0	1997	Biodegradation of DEHP, DBP, and DINP: poorly water soluble and widely used phthalate plasticizers.	Water	46-51	D-box binding PAR bZIP transcription factor	Homo sapiens	24-27
9095083-6	1997	The renal cytolocalization of the Ang II/AVP receptor to the outer medullary thick ascending limb tubules and inner medullary collecting ducts is consistent with the well-established AVP stimulation of sodium and water reabsorption in these tubules.	Water	213-218	arginine vasopressin	Homo sapiens	183-186
9326738-0	1997	Effect of rilmenidine injection into the paraventricular nucleus of the hypothalamus on the water intake induced by application of angiotensin II to the subfornical organ.	Water	92-97	angiotensinogen	Homo sapiens	131-145
9119993-1	1997	Aquaporin-2 (AQP2) mediates vasopressin-regulated collecting duct water permeability.	Water	66-71	arginine vasopressin	Rattus norvegicus	28-39
9119993-12	1997	The results indicate a major role for vasopressin in the upregulation of AQP2 water channels and water retention in experimental CHF in the rat.	Water	78-83	arginine vasopressin	Rattus norvegicus	38-49
9119993-12	1997	The results indicate a major role for vasopressin in the upregulation of AQP2 water channels and water retention in experimental CHF in the rat.	Water	97-102	arginine vasopressin	Rattus norvegicus	38-49
9174977-1	1997	The effect of the water soluble fraction of the ethanol extract of Nyctanthes arbor-tristis (NAT) on tumor necrosis factor-alpha (TNF-alpha) level in plasma of arthritic and soluble protein A (SpA)-treated Balb/c mice has been studied.	Water	18-23	tumor necrosis factor	Mus musculus	101-128
9174977-1	1997	The effect of the water soluble fraction of the ethanol extract of Nyctanthes arbor-tristis (NAT) on tumor necrosis factor-alpha (TNF-alpha) level in plasma of arthritic and soluble protein A (SpA)-treated Balb/c mice has been studied.	Water	18-23	tumor necrosis factor	Mus musculus	130-139
9111231-8	1997	The sensitivity of LC1 epitopes to proton and water activities may reflect molecular properties important to LC1"s roles in vivo.	Water	46-51	annexin A1	Rattus norvegicus	19-22
9111231-8	1997	The sensitivity of LC1 epitopes to proton and water activities may reflect molecular properties important to LC1"s roles in vivo.	Water	46-51	annexin A1	Rattus norvegicus	109-112
9188188-2	1997	To this end, the oxidized chain B from insulin (INS) (S = 5% in demineralized water) was subjected to tryptic proteolysis (E/S = 1/50; pH 5; 37 degrees C; 24 h).	Water	78-83	insulin	Homo sapiens	39-46
9095192-0	1997	Molecular design of aquaporin-1 water channel as revealed by electron crystallography.	Water	32-37	aquaporin 1 (Colton blood group)	Homo sapiens	20-31
9095192-1	1997	The electron crystallographic structure of the aquaporin-1 water channel, determined at approximately 6A, reveals that the protein has six transmembrane alpha-helices forming a trapezoid-like cylinder.	Water	59-64	aquaporin 1 (Colton blood group)	Homo sapiens	47-58
9140137-7	1997	The partition coefficient of rac-DMSA in the n-octanol/water system was found to be about 2.8.	Water	55-60	Rac family small GTPase 2	Rattus norvegicus	29-32
9100605-4	1997	The time-restricted food and water intakes were associated with variations of gastric pH, plasma gastrin, insulin, glucose, and calcium documented on a circadian basis.	Water	29-34	insulin	Homo sapiens	106-113
11669706-12	1997	The complexes [In(bped)](+) and [In(bped)(OH)] are proposed to contain 7-coordinate In(III) with water and hydroxide completing the respective coordination spheres.	Water	97-102	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	87-90
9096382-1	1997	A replication-deficient, recombinant adenovirus encoding human aquaporin-1 (hAQP1), the archetypal water channel, was constructed.	Water	99-104	aquaporin 1 (Colton blood group)	Homo sapiens	63-74
9096382-1	1997	A replication-deficient, recombinant adenovirus encoding human aquaporin-1 (hAQP1), the archetypal water channel, was constructed.	Water	99-104	aquaporin 1 (Colton blood group)	Homo sapiens	76-81
9131991-8	1997	At the oil-water interface, in the absence or presence of bile salts below their CMC, it can be concluded that the colipase is a true lipase cofactor, i.e, it increases the enzyme turnover (approximately 10-15-fold) and does not affect the interfacial lipase adsorption.	Water	11-16	colipase	Homo sapiens	115-123
9077550-0	1997	Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct.	Water	95-100	arginine vasopressin	Rattus norvegicus	74-85
9077550-1	1997	During antidiuresis, increases in vasopressin (AVP)-elicited osmotic water permeability in the terminal inner medullary collecting duct (tIMCD) raise luminal calcium concentrations to levels (&gt; or = 5 mM) above those associated with the formation of calcium-containing precipitates in the urine.	Water	69-74	arginine vasopressin	Rattus norvegicus	34-45
9095349-0	1997	Mitogenic activities of water-soluble and -insoluble insulin conjugates.	Water	24-29	insulin	Homo sapiens	53-60
9095349-1	1997	Insulin was covalently bound to water-soluble polymers such as poly(oxyethylene) and poly(acrylic acid).	Water	32-37	insulin	Homo sapiens	0-7
9095367-4	1997	The PEO-modified myoglobin, cast on the electrode from water or a methanol solution, showed quasi-reversible redox reactions in PEO (average MW of 400).	Water	55-60	myoglobin	Equus caballus	17-26
9095349-3	1997	Insulin was also bound to a poly(acrylic acid)-grafted polystyrene film, to form a water-insoluble multivalent conjugate.	Water	83-88	insulin	Homo sapiens	0-7
9095349-6	1997	A concentration of immobilized insulin much lower than that of native insulin and the water-soluble insulin conjugates accelerated cell growth.	Water	86-91	insulin	Homo sapiens	31-38
9095349-8	1997	The findings suggest that the mitogenic effect of the water-insoluble, multivalent insulin conjugate lasts longer than that of the water-soluble conjugates, owing to the absence of internalization into the cell.	Water	54-59	insulin	Homo sapiens	83-90
9089759-5	1997	The day after the first administration of TNF (acute phase), food and water intake, as well as body weight, of all rats decreased.	Water	70-75	tumor necrosis factor	Rattus norvegicus	42-45
9138683-19	1997	These results suggest that the central NK3 receptor, probably located in the hypothalamus, is implicated in the renal control of water and electrolyte homeostasis through the release of vasopressin in the conscious saline-loaded rat.	Water	129-134	arginine vasopressin	Rattus norvegicus	186-197
9074995-8	1997	Examples from a recording of a 13-wk-old full-term infant obtained by using the system give evaporative water loss rates of approximately 0.02 mgH2O.cm-2.min-1 for normothermic baseline conditions and values up to 0.4 mgH2O.cm-2.	Water	104-109	CD59 molecule (CD59 blood group)	Homo sapiens	154-159
9071281-13	1997	The experimental results are more consistent with water interacting with a paramagnetic substance or low molecular weight molecule (e.g., vasopressin, neurophysins).	Water	50-55	arginine vasopressin	Homo sapiens	138-149
9075137-2	1997	In this study we show how the equilibrated postdialysis urea concentration (Ceq) and Kt/V corrected for double-pool urea kinetics (Kt/Vdp) can be accurately determined using an on-line sensor providing a continuous measure of blood water urea.	Water	232-237	USO1 vesicle transport factor	Homo sapiens	134-137
9094741-7	1997	In addition, comparison of the water residence times at nonpolar, polar, positively charged, or negatively charged sites on the surface of SP-C or titin does not reveal pronounced or definite differences.	Water	31-36	surfactant protein C	Homo sapiens	139-143
9111950-4	1997	The iron transport protein transferrin showed distinct differences in adsorption to a variety of hydroxyapatite and tricalcium phosphate powders, with higher concentrations of transferrin adsorbed to powders which caused no change or a drop in the pH of cell culture medium or water.	Water	277-282	transferrin	Homo sapiens	27-38
9119028-9	1997	When astrocytes were incubated first with eicosatetraynoic acid, a structural analogue competing in arachidonic acid metabolism, the stimulation of JNK by H2O was also inhibited, suggesting the involvement of arachidonic acid metabolites.	Water	155-158	mitogen-activated protein kinase 8	Homo sapiens	148-151
9062505-0	1997	Deuterium and bromide dilution, and bioimpedance spectrometry independently show that growth hormone-deficient adults have an enlarged extracellular water compartment related to intracellular water.	Water	149-154	growth hormone 1	Homo sapiens	86-100
9062505-0	1997	Deuterium and bromide dilution, and bioimpedance spectrometry independently show that growth hormone-deficient adults have an enlarged extracellular water compartment related to intracellular water.	Water	192-197	growth hormone 1	Homo sapiens	86-100
9296068-12	1997	Angiotensiongen is the substrate of renin, and the renin-angiotensinogen reaction is the first and limiting step in the pathway that leads to production of angiotensin II, a peptide with important effects on blood pressure control and the metabolism of water and sodium.	Water	253-258	renin	Homo sapiens	36-41
9296068-12	1997	Angiotensiongen is the substrate of renin, and the renin-angiotensinogen reaction is the first and limiting step in the pathway that leads to production of angiotensin II, a peptide with important effects on blood pressure control and the metabolism of water and sodium.	Water	253-258	renin	Homo sapiens	51-56
9296068-12	1997	Angiotensiongen is the substrate of renin, and the renin-angiotensinogen reaction is the first and limiting step in the pathway that leads to production of angiotensin II, a peptide with important effects on blood pressure control and the metabolism of water and sodium.	Water	253-258	angiotensinogen	Homo sapiens	57-72
9296068-12	1997	Angiotensiongen is the substrate of renin, and the renin-angiotensinogen reaction is the first and limiting step in the pathway that leads to production of angiotensin II, a peptide with important effects on blood pressure control and the metabolism of water and sodium.	Water	253-258	angiotensinogen	Homo sapiens	156-170
9089759-7	1997	Specifically, after the third administration, the rats treated with TNF had a higher amount of water intake than the control rats.	Water	95-100	tumor necrosis factor	Rattus norvegicus	68-71
9108691-7	1997	This channel, extending from the active site to the opposite surface of the enzyme, was first noted in the hirudin-thrombin structure and contains about 20 conserved water molecules linked together by a hydrogen bonding network that connects to the main chain of thrombin.	Water	166-171	coagulation factor II, thrombin	Homo sapiens	115-123
9124394-2	1997	We determined whether the abrupt decrease in circulating arginine vasopressin (AVP) by giving excess water affects the expression of AQP-2 mRNA and subcellular localization of AQP-2 in collecting duct cells of the dehydrated rats.	Water	101-106	arginine vasopressin	Rattus norvegicus	66-77
9124394-2	1997	We determined whether the abrupt decrease in circulating arginine vasopressin (AVP) by giving excess water affects the expression of AQP-2 mRNA and subcellular localization of AQP-2 in collecting duct cells of the dehydrated rats.	Water	101-106	arginine vasopressin	Rattus norvegicus	79-82
9124394-3	1997	The 72-h water deprivation increased plasma AVP levels to 3.1 pg/ml and the expression of AQP-2 mRNA by 336% in rats, which were concomitantly abolished by the 40 ml/kg oral water load.	Water	9-14	arginine vasopressin	Rattus norvegicus	44-47
9124394-3	1997	The 72-h water deprivation increased plasma AVP levels to 3.1 pg/ml and the expression of AQP-2 mRNA by 336% in rats, which were concomitantly abolished by the 40 ml/kg oral water load.	Water	174-179	arginine vasopressin	Rattus norvegicus	44-47
9115611-4	1997	The wound produced by applying a lint for 10 s, and no treatment applied thereafter, and the wound produced by applying a lint for 10 s and immediately after soaked with tap water for 1 min, resulted in moderate damage.	Water	174-179	nuclear RNA export factor 1	Rattus norvegicus	170-173
9048343-0	1997	New mutations in the AQP2 gene in nephrogenic diabetes insipidus resulting in functional but misrouted water channels.	Water	103-108	aquaporin 2 S homeolog	Xenopus laevis	21-25
9048343-2	1997	The autosomal recessive form of NDI is caused by mutations in the AQP2 gene, encoding the vasopressin-regulated water channel of the kidney collecting duct.	Water	112-117	aquaporin 2 S homeolog	Xenopus laevis	66-70
9048343-4	1997	Expression of the A147T and T126M mutant AQP2 proteins in Xenopus oocytes revealed a relatively small, but significant increase in water permeability, whereas the water permeability of N68S expressing oocytes was not increased.	Water	131-136	aquaporin 2 S homeolog	Xenopus laevis	41-45
9144834-3	1997	The trained mice underwent a 6-week swimming program (1 h/day, 5 days/week) in water at 35-36 degrees C. Cu,Zn-superoxide dismutase (Cu,Zn-SOD) activity was significantly decreased with aging but was not influenced by swimming training, such changes being similar to those noted for catalase activity rather than for glutathione peroxidase activity.	Water	79-84	superoxide dismutase 1, soluble	Mus musculus	105-131
9144834-3	1997	The trained mice underwent a 6-week swimming program (1 h/day, 5 days/week) in water at 35-36 degrees C. Cu,Zn-superoxide dismutase (Cu,Zn-SOD) activity was significantly decreased with aging but was not influenced by swimming training, such changes being similar to those noted for catalase activity rather than for glutathione peroxidase activity.	Water	79-84	superoxide dismutase 1, soluble	Mus musculus	133-142
10325618-0	1997	[The method to remove nitrite from tap water by tea].	Water	39-44	SEC14 like lipid binding 2	Homo sapiens	35-38
10325618-5	1997	As a natural antioxidant, tea contains several antioxidants, such as ascorbic acid and catechins, which removed NO2- from tap water effectively.	Water	126-131	SEC14 like lipid binding 2	Homo sapiens	122-125
9098972-3	1997	The C18 silica rods gave minimum plate heights of 10-15 microns for aromatic hydrocarbons in 80% methanol and of 20-30 microns for insulin in acetonitrile-water mixtures in the presence of trifluoroacetic acid.	Water	155-160	insulin	Homo sapiens	131-138
9063092-1	1997	The water extract from the root of Salvia miltiorhiza Bunge showed a protective effect on cultured rat hepatocytes against carbon tetrachloride (CCl4)-induced necrosis.	Water	4-9	C-C motif chemokine ligand 4	Rattus norvegicus	145-149
9020785-0	1997	Structural dynamics of water and the peptide backbone around the Schiff base associated with the light-activated process of octopus rhodopsin.	Water	23-28	rhodopsin	Homo sapiens	132-141
9020791-2	1997	This study investigated the effect of cholesterol on the way in which hydrophobic SP-B and SP-C modulated the adsorption of lipid into the air-water interface and their respreading from collapsed phase produced on overcompression of the surface film.	Water	143-148	surfactant protein C	Homo sapiens	91-95
9108691-7	1997	This channel, extending from the active site to the opposite surface of the enzyme, was first noted in the hirudin-thrombin structure and contains about 20 conserved water molecules linked together by a hydrogen bonding network that connects to the main chain of thrombin.	Water	166-171	coagulation factor II, thrombin	Homo sapiens	263-271
9108691-9	1997	A water molecule with octahedral coordination has also been identified in factor Xa at the topologically equivalent Na+ site position of thrombin.	Water	2-7	coagulation factor II, thrombin	Homo sapiens	137-145
9028884-0	1997	Surface Tension Kinetics of the Wild Type and Four Synthetic Stability Mutants of T4 Phage Lysozyme at the Air-Water Interface Surface tension kinetics exhibited by the wild type and selected stability mutants of T4 lysozyme at the air-water interface were monitored with DuNouy tensiometry.	Water	111-116	lysozyme	Homo sapiens	91-99
9016333-1	1997	The natural peptide [Thr6]-bradykinin, Arg1-Pro2-Pro3-Gly4-Phe5-Thr6-Pro7-Phe8-Arg9, has been conformationally examined by molecular dynamics simulations using a two-phase box consisting of H2O and CCl4 to mimic the micellar environment utilized in the 1H-NMR studies.	Water	190-193	kininogen 1	Homo sapiens	27-37
9030899-5	1997	We suggest that endothelin-1 and the endothelin ETA receptor play an important role in water and sodium retention, and in renal vasoconstriction in this model of hypertension.	Water	87-92	endothelin 1	Rattus norvegicus	16-28
8995362-14	1997	We conclude that the tryptophan cluster Trp390-Trp393-Trp394 contributes to binding of lipoprotein lipase to lipid/water interfaces.	Water	115-120	lipoprotein lipase	Rattus norvegicus	87-105
9014028-10	1997	The control group was not made thiamin deficient and consumed lab chow and tap water throughout.	Water	79-84	nuclear RNA export factor 1	Rattus norvegicus	75-78
9479425-1	1997	Centrally released arginine vasopressin (AVP) has been implicated in the regulation of the brain water content and is elevated in the cerebrospinal fluid of patients with ischaemic and traumatic brain injuries.	Water	97-102	arginine vasopressin	Rattus norvegicus	28-39
9360641-0	1997	Water channel AQP1, 3, and 4 in the human peritoneum and peritoneal dialysate.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	14-18
9356672-1	1997	The recently identified molecular structure of the Colton blood group system is characterized by an amino acid substitution at position 45 (Colton a: alanine, Colton b: valine) of the archetypical water channel protein Aquaporin-1 (AQP1), which regulates water homeostasis in the erythrocyte membrane and in the proximal tubule of the nephron.	Water	197-202	aquaporin 1 (Colton blood group)	Homo sapiens	219-230
9356672-1	1997	The recently identified molecular structure of the Colton blood group system is characterized by an amino acid substitution at position 45 (Colton a: alanine, Colton b: valine) of the archetypical water channel protein Aquaporin-1 (AQP1), which regulates water homeostasis in the erythrocyte membrane and in the proximal tubule of the nephron.	Water	197-202	aquaporin 1 (Colton blood group)	Homo sapiens	232-236
18629952-3	1997	The ability of immobilized transferrin to produce clean water was demonstrated.	Water	56-61	transferrin	Homo sapiens	27-38
9192044-7	1997	One approach is illustrated in which antigen and adjuvant are incorporated in the inner water phase of a water-in-oil-in-water or multiple emulsion, thus protecting antigen and delivering it into GALT.	Water	88-93	galactose-1-phosphate uridylyltransferase	Homo sapiens	196-200
9192044-7	1997	One approach is illustrated in which antigen and adjuvant are incorporated in the inner water phase of a water-in-oil-in-water or multiple emulsion, thus protecting antigen and delivering it into GALT.	Water	105-110	galactose-1-phosphate uridylyltransferase	Homo sapiens	196-200
9192044-7	1997	One approach is illustrated in which antigen and adjuvant are incorporated in the inner water phase of a water-in-oil-in-water or multiple emulsion, thus protecting antigen and delivering it into GALT.	Water	105-110	galactose-1-phosphate uridylyltransferase	Homo sapiens	196-200
9360697-11	1997	The supine position allowed the 25% Pip increment from 10.2 +/- 2.5 to 12.5 +/- 3.1 cm water, without any obvious clinical side effects.	Water	87-92	prolactin induced protein	Homo sapiens	36-39
9002526-3	1997	ET-1 exerts a wide range of biologic effects in the kidney, including constriction of most renal vessels, mesangial cell contraction, inhibition of sodium and water reabsorption by the nephron, enhancement of glomerular cell proliferation, and stimulation of extracellular matrix accumulation.	Water	159-164	endothelin 1	Homo sapiens	0-4
9002526-10	1997	Deranged ET-1 production in the nephron may cause inappropriate sodium and water retention, thereby contributing to the development and/or maintenance of hypertension.	Water	75-80	endothelin 1	Homo sapiens	9-13
9039031-3	1997	In hydrated rats, the graded infusion of vasopressin (10-1,000 pg.min 1.kg body wt-1) resulted in a dose-dependent antidiuresis: decreases in urine flow and free water clearance and an increase in urine osmolality.	Water	162-167	arginine vasopressin	Rattus norvegicus	41-52
9039031-8	1997	In a separate experiment in rats without water hydration and urine collection, infusion of pressor doses of vasopressin (1,000-6,000 pg.min-1.kg body wt-1) resulted in a greater increase in blood pressure in male than in nonestrous female rats.	Water	41-46	arginine vasopressin	Rattus norvegicus	108-119
9039043-4	1997	One of these water channels, aquaporin-2, has been shown to be the target for short-term regulation of collecting duct water permeability by vasopressin.	Water	13-18	arginine vasopressin	Homo sapiens	141-152
9039043-4	1997	One of these water channels, aquaporin-2, has been shown to be the target for short-term regulation of collecting duct water permeability by vasopressin.	Water	119-124	arginine vasopressin	Homo sapiens	141-152
9039043-5	1997	In addition, two collecting duct water channels, aquaporin-2 and aquaporin-3, are targets for long-term regulation by vasopressin through effects on the absolute expression levels of the water channel proteins.	Water	33-38	arginine vasopressin	Homo sapiens	118-129
9349414-6	1997	We conclude that susceptibility to EAU is connected with a Th1-dominant response, but resistance can involve either a "null", F344-like response (Th1-low/Th2-low) or a Th2-dominant response.	Water	35-38	negative elongation factor complex member C/D, Th1l	Mus musculus	59-62
15093378-0	1997	Removal of TNT and RDX from water and soil using iron metal.	Water	28-33	chromosome 16 open reading frame 82	Homo sapiens	11-14
15093378-2	1997	Our objective was to determine if zero-valent iron (Fe(0)) could be used to promote remediation of water and soil contaminated with 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX).	Water	99-104	chromosome 16 open reading frame 82	Homo sapiens	155-158
9241582-4	1997	In this report we describe enclosure of insulin-releasing cells into water-insoluble poly(2-hydroxyethyl methacrylate) and poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) membranes using X-ray contrast medium as a solvent without use of any special apparatus.	Water	69-74	insulin	Homo sapiens	40-47
9362389-4	1997	In addition to sensing Ca2+o and Mg2+o abnormally (the latter suggesting the CaR acts as an Mg2+o-sensing receptor), persons with FHH have alterations in their handling of water, supporting a role for the CaR in integrating mineral ion and water metabolism.	Water	172-177	calcium sensing receptor	Homo sapiens	77-80
9362389-4	1997	In addition to sensing Ca2+o and Mg2+o abnormally (the latter suggesting the CaR acts as an Mg2+o-sensing receptor), persons with FHH have alterations in their handling of water, supporting a role for the CaR in integrating mineral ion and water metabolism.	Water	240-245	calcium sensing receptor	Homo sapiens	77-80
9043798-13	1997	Aquaporin 2, also called WCH-CD, is the water channel of the principal cell of the cortical and medullary collecting duct, and is located in cytoplasmic vesicles unless arginine vasopressin is acting, when it is translocated to the apical membrane by synaptobrevins or vesicle associated membrane protein 2 (VAMP2).	Water	40-45	vesicle associated membrane protein 2	Homo sapiens	269-306
9043798-13	1997	Aquaporin 2, also called WCH-CD, is the water channel of the principal cell of the cortical and medullary collecting duct, and is located in cytoplasmic vesicles unless arginine vasopressin is acting, when it is translocated to the apical membrane by synaptobrevins or vesicle associated membrane protein 2 (VAMP2).	Water	40-45	vesicle associated membrane protein 2	Homo sapiens	308-313
9043814-2	1997	In addition to its effects at the renal tubules to influence water retention and at vascular smooth muscle to cause vasoconstriction, the hormone arginine vasopressin also appears to modulate cardiovascular reflex control of the sympathetic nervous system.	Water	61-66	arginine vasopressin	Homo sapiens	155-166
9505202-4	1997	When the hydrogel complexed with lysozyme was placed in deionized water and various KCl solutions, of varying concentrations of up to 0.5 M KCl, no lysozyme was released in deionized water, while increasing amounts of lysozyme were released as the KCl concentration increased.	Water	66-71	lysozyme	Homo sapiens	33-41
9505202-4	1997	When the hydrogel complexed with lysozyme was placed in deionized water and various KCl solutions, of varying concentrations of up to 0.5 M KCl, no lysozyme was released in deionized water, while increasing amounts of lysozyme were released as the KCl concentration increased.	Water	183-188	lysozyme	Homo sapiens	33-41
9591199-11	1997	Moreover, water-soluble OSCs such as S-methylcysteine and cysteine similarly decreased GST-P focus formation.	Water	10-15	glutathione S-transferase pi 1	Rattus norvegicus	87-92
9453452-0	1997	Influence of water immersion on plasma erythropoietin concentration in patients with essential hypertension.	Water	13-18	erythropoietin	Homo sapiens	39-53
8987761-1	1997	The activation of neurons in the subfornical organ (SFO) by angiotensin II (AngII) is well established and is widely regarded as the basis for the AngII-induced increase in water intake.	Water	173-178	angiotensinogen	Homo sapiens	60-74
8987761-1	1997	The activation of neurons in the subfornical organ (SFO) by angiotensin II (AngII) is well established and is widely regarded as the basis for the AngII-induced increase in water intake.	Water	173-178	angiotensinogen	Homo sapiens	76-81
9050237-8	1997	The localization of the CaSR transcripts and protein in the kidney not only provides a basis for a direct Ca2+0 (or Mg2+0)-mediated regulation of Ca2+ (and Mg2+) excretion but also suggests a functional link between divalent mineral and water metabolism.	Water	237-242	calcium sensing receptor	Homo sapiens	24-28
9050237-10	1997	Recent studies have suggested models whereby extracellular Ca2+, via the CaSR expressed in the TAL as well as in the collecting duct system, modulates both Ca2+ 0 and Mg2+ 0 as well as water reabsorbtion.	Water	185-190	calcium sensing receptor	Homo sapiens	73-77
8987761-1	1997	The activation of neurons in the subfornical organ (SFO) by angiotensin II (AngII) is well established and is widely regarded as the basis for the AngII-induced increase in water intake.	Water	173-178	angiotensinogen	Homo sapiens	147-152
8987761-7	1997	These electrophysiological results suggest an important role for NO in SFO-mediated responses and offer a plausible explanation for the in vivo-observed opposite effects of AngII and NO on water intake.	Water	189-194	angiotensinogen	Homo sapiens	173-178
9453452-8	1997	CONCLUSIONS: (1) water immersion induced increase in plasma EPO both in healthy subjects and patients with essential hypertension.	Water	17-22	erythropoietin	Homo sapiens	60-63
8989324-1	1997	Submillisecond folding of cytochrome c reveals that a nascent phase appears within the mixing dead time of 100 microseconds, followed by a ligand exchange reaction during which His 26/33, water and Met 80 are inter-exchanged as haem ligands through a thermodynamically controlled equilibrium.	Water	188-193	cytochrome c, somatic	Homo sapiens	26-38
8995537-13	1997	In the future, analogues of nociceptin may prove to be the first clinically useful water diuretics for patients with water-retaining diseases.	Water	83-88	prepronociceptin	Homo sapiens	28-38
8995537-13	1997	In the future, analogues of nociceptin may prove to be the first clinically useful water diuretics for patients with water-retaining diseases.	Water	117-122	prepronociceptin	Homo sapiens	28-38
9357055-1	1997	The role of brain angiotensin II (ANG II) in water, Na and food intake of rats was studied.	Water	45-50	angiotensinogen	Rattus norvegicus	18-32
9171309-7	1997	In addition, restriction of water or administration of demeclocycline improved plasma sodium and plasma vasopressin levels relative to plasma osmolality to be normal.	Water	28-33	arginine vasopressin	Homo sapiens	104-115
9149296-0	1997	Interactions between angiotensin II and delta opioid receptor subtype agonists upon water intake in rats.	Water	84-89	angiotensinogen	Rattus norvegicus	21-35
9149296-8	1997	In contrast, pairing ineffective doses of Delt II (5 ug) and AII (0.2 ng) significantly increased water intake that persisted when either the Delt II dose (1 ug) or the AII dose (0.02 ng) was lowered.	Water	98-103	angiotensinogen	Rattus norvegicus	61-64
9149296-8	1997	In contrast, pairing ineffective doses of Delt II (5 ug) and AII (0.2 ng) significantly increased water intake that persisted when either the Delt II dose (1 ug) or the AII dose (0.02 ng) was lowered.	Water	98-103	angiotensinogen	Rattus norvegicus	169-172
9149296-10	1997	Thus, delta2 opioid agonism appeared more consistent and reliable than delta1 opioid agonism in stimulating water intake when paired with AII, and these data indicate interactions between delta1 and delta2 agonists and AII in mediating water intake.	Water	236-241	angiotensinogen	Rattus norvegicus	219-222
8970186-1	1997	An enhancing activity for the release of tumor necrosis factor-alpha from macrophages of C3H/HeJ mice was detected in the hot water-soluble extract of an edible brown alga, Hijikia fusiforme (Hijiki in Japanese).	Water	126-131	tumor necrosis factor	Mus musculus	41-68
9285931-2	1997	injection of tachykinins (TKs) inhibits ethanol intake and angiotensin II-induced water intake; the effects are apparently mediated by NK-3 and NK-1 receptors, respectively.	Water	82-87	angiotensinogen	Rattus norvegicus	59-73
9357055-1	1997	The role of brain angiotensin II (ANG II) in water, Na and food intake of rats was studied.	Water	45-50	angiotensinogen	Rattus norvegicus	34-40
9357055-7	1997	In conclusion, evidence was consistent with a role for brain ANG II in both food and water intake after food deprivation but not in thirst subsequent to water deprivation or Na intake after Na depletion alone.	Water	85-90	angiotensinogen	Rattus norvegicus	61-67
9165602-2	1997	Vasopressin plays an important role in regulation of water metabolism, and under normal conditions the kidney collecting duct is extremely sensitive to vasopressin.	Water	53-58	arginine vasopressin	Homo sapiens	0-11
9396069-2	1997	PYY3-36 has been found in human and rabbit blood within 30 min of the beginning of the meal, when the peak of water and electrolyte secretion occurs in the duodeno-jejunum.	Water	110-115	peptide YY 3 (pseudogene)	Homo sapiens	0-4
9373873-4	1997	Seeds were sprouted either in distilled- or tap-water and in five different electrolyte solutions to investigate the concentration-dependent uptake.	Water	48-53	common wheat expressed sequence tag	Triticum aestivum	44-47
9039242-2	1997	Vasopressin, a powerful antidiuretic hormone involved in salt and water homeostasis, is released in response to acute hypoxia.	Water	66-71	arginine vasopressin	Rattus norvegicus	0-11
9003357-0	1996	Lactase phlorhizin hydrolase turnover in vivo in water-fed and colostrum-fed newborn pigs.	Water	49-54	lactase phlorizin hydrolase	Sus scrofa	0-28
8978549-6	1996	We calculate the changes in the lower critical solution temperature (LCST) for the C8E5 micelle-salt-water mixture as a function of salt concentration for the salts NaF, NaCl, NaBr, NaI, and Na2SO4 and compare the trends seen with experiments.	Water	101-106	C-X-C motif chemokine ligand 8	Homo sapiens	165-168
9000620-1	1996	Aquaporin-1 (AQP1) is an abundant protein in human erythrocyte membranes which functions as a specific and constitutively active water conducting pore.	Water	129-134	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
9000620-1	1996	Aquaporin-1 (AQP1) is an abundant protein in human erythrocyte membranes which functions as a specific and constitutively active water conducting pore.	Water	129-134	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
9022219-0	1996	Effects of distearoylphosphatidylglycerol and lysozyme on the structure of the monoolein-water cubic phase: X-ray diffraction and Raman scattering studies.	Water	89-94	lysozyme	Homo sapiens	11-54
9017229-7	1996	These findings suggest that NK-3 receptors in the PVN may be involved in water regulation by stimulation of vasopressin secretion from the posterior pituitary gland, and that vasopressin caused water reabsorbtion via the kidney V2 receptor.	Water	73-78	arginine vasopressin	Rattus norvegicus	108-119
9017229-7	1996	These findings suggest that NK-3 receptors in the PVN may be involved in water regulation by stimulation of vasopressin secretion from the posterior pituitary gland, and that vasopressin caused water reabsorbtion via the kidney V2 receptor.	Water	194-199	arginine vasopressin	Rattus norvegicus	175-186
9003357-1	1996	We have estimated the synthesis rates in vivo of precursor and brush-border (BB) polypeptides of lactase phlorhizin hydrolase (LPH) in newborn pigs fed with water or colostrum for 24h post partum.	Water	157-162	lactase phlorizin hydrolase	Sus scrofa	97-125
9003357-1	1996	We have estimated the synthesis rates in vivo of precursor and brush-border (BB) polypeptides of lactase phlorhizin hydrolase (LPH) in newborn pigs fed with water or colostrum for 24h post partum.	Water	157-162	lactase phlorizin hydrolase	Sus scrofa	127-130
9003357-11	1996	However, the proportion of newly synthesized proLPHh processed to BB LPH was 48% lower in colostrum-fed than in water-fed animals.	Water	112-117	lactase phlorizin hydrolase	Sus scrofa	48-51
8971291-12	1996	Water immersion stress increased gastric mucosal IL-1 beta and IL-2 contents 6 h after stress treatment, and these increases were prevented by FK506.	Water	0-5	interleukin 1 beta	Rattus norvegicus	49-58
8972697-14	1996	(vi) Comparison of the calculated dipoles with those estimated for the crystalline conformation of the [MoNa(H2O)2] and [MoK(H2O)2] complexes reveals that the MoNa may exist in the membrane at its crystal configuration, while the MoK definitely attains a structure having a dipole moment larger than in the crystal.	Water	109-112	MOK protein kinase	Homo sapiens	230-233
8972697-14	1996	(vi) Comparison of the calculated dipoles with those estimated for the crystalline conformation of the [MoNa(H2O)2] and [MoK(H2O)2] complexes reveals that the MoNa may exist in the membrane at its crystal configuration, while the MoK definitely attains a structure having a dipole moment larger than in the crystal.	Water	125-128	MOK protein kinase	Homo sapiens	121-124
19245448-0	1996	Effect of Vichy water on catalase activity in the stratum corneum.	Water	16-21	catalase	Homo sapiens	25-33
8957033-15	1996	It is concluded that in progressive chronic nephropathy ACE-inhibitor treatment was associated with different adaptive tubular changes in the handling of sodium, water, and protein compared with conventional antihypertensive therapy.	Water	162-167	angiotensin I converting enzyme	Homo sapiens	56-59
8946804-9	1996	The solvent-water molecule forms two hydrogen bonds with peptide molecule involving NH of Val1 as an acceptor and another with CO of a symmetry related (1-x, y-1/2, 1/2 -z) delta Phe3 as a donor.	Water	12-17	RNA, Ro60-associated Y1	Homo sapiens	158-171
19245448-7	1996	Considering the involvement of catalase in skin defence against oxygen-derived free radicals generated, its increased activity may explain the beneficial role of Vichy water observed in various dermatoses.	Water	168-173	catalase	Homo sapiens	31-39
8910473-1	1996	The gene mutated in cystic fibrosis codes for the cystic fibrosis transmembrane conductance regulator (CFTR), a cyclic AMP-activated chloride channel thought to be critical for salt and water transport by epithelial cells.	Water	186-191	CF transmembrane conductance regulator	Homo sapiens	50-101
8958221-10	1996	Taken together, our data show that UT1 corresponds to the previously characterized vasopressin-regulated urea transporter in the apical membrane of the terminal IMCD which plays a critical role in renal water conservation.	Water	203-208	arginine vasopressin	Rattus norvegicus	83-94
8939759-7	1996	The two inhibitors based on 4-aminopyridine bind in notably different ways: one forms a water-mediated hydrogen bond to the active site Ser195, the other induces a rotation of the Ser214-Trp215 peptide plane that is unprecedented in thrombin structures.	Water	88-93	coagulation factor II, thrombin	Homo sapiens	233-241
8920898-1	1996	Aquaporin 1 is an integral membrane protein which functions as a water channel.	Water	65-70	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
8910473-1	1996	The gene mutated in cystic fibrosis codes for the cystic fibrosis transmembrane conductance regulator (CFTR), a cyclic AMP-activated chloride channel thought to be critical for salt and water transport by epithelial cells.	Water	186-191	CF transmembrane conductance regulator	Homo sapiens	103-107
8909288-4	1996	We report here that an active congener, A beta (10-35)-NH2, displays time dependence, pH-activity profile, and kinetic order of deposition similar to A beta (1-40), and is sufficiently soluble for NMR spectroscopy in water under conditions where it actively deposits.	Water	217-222	amyloid beta precursor protein	Homo sapiens	40-46
8951168-2	1996	The water extract of propolis (PWE) showed a strong hepatoprotective activity against CCl4-toxicity in rats and D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver injury in mice.	Water	4-9	C-C motif chemokine ligand 4	Rattus norvegicus	86-90
8912743-2	1996	The ventilatory effect of CFI (15 +/- 2 L/min) generating a positive pressure of about 10 cm H2O with concomitant chest compression was studied first.	Water	93-96	complement factor I	Sus scrofa	26-29
8980165-2	1996	Both insulin and lack of natriuretic counteracting response lead to water expansion, while hyperglycemica-induced osmotic diuresis leads to water depletion.	Water	68-73	insulin	Homo sapiens	5-12
8921953-2	1996	Here we report that a selected adjuvant comprising block copolymers in a water-in-oil emulsion can induce balanced TH1/TH2 responses in BALB/c mice primed at 1 week of age with an immunodominant tetanus peptide vaccine.	Water	73-78	negative elongation factor complex member C/D, Th1l	Mus musculus	115-118
9196552-5	1996	These results indicate that both DuP753 and PD123329, administered into the PVN, blocked the water and sodium intake induced by administration of ANG II into the same site.	Water	93-98	angiotensinogen	Rattus norvegicus	146-152
9019714-0	1996	AVP-independent high osmotic water permeability of frog urinary bladder and autacoids.	Water	29-34	arginine vasopressin	Homo sapiens	0-3
9022280-2	1996	Angiotensin II, the end product of the reaction, is an extremely potent vasoconstrictor and a major determinant of salt and water homeostasis.	Water	124-129	angiotensinogen	Homo sapiens	0-14
9022285-6	1996	Anoxia exposure of turtles in vivo, via submergence in N2-gassed water at 7 degrees C, altered the activity and subcellular distribution of PKC in liver.	Water	65-70	proline rich transmembrane protein 2	Homo sapiens	140-143
9091852-0	1996	[The influence of water immersion on serum erythropoietin concentration in patients with essential arterial hypertension].	Water	18-23	erythropoietin	Homo sapiens	43-57
8887526-1	1996	A lower limit of detection of 0.04 Bq L-1 for measuring 131I in milk or water with a gamma-ray spectrometer was achieved with a large 118% intrinsic germanium detector.	Water	72-77	immunoglobulin kappa variable 1-16	Homo sapiens	38-41
9019714-2	1996	This increase of the osmotic water permeability was of the same magnitude as that of the effect of 1 nM AVP.	Water	29-34	arginine vasopressin	Homo sapiens	104-107
9019714-4	1996	Immunocytochemical studies using anti-actin monoclonal antibodies indicated depolymerization of F-actin following the AVP-independent change in water permeability.	Water	144-149	arginine vasopressin	Homo sapiens	118-121
8890892-1	1996	Cu(2+)-mediated complex formation between polyacrylic acid (PAA) and negatively charged bovine serum albumin (BSA) was studied in neutral water in the presence of Cu2+.	Water	138-143	albumin	Homo sapiens	95-108
8953655-6	1996	There is one Bet v 1 molecule per asymmetric unit and the water content is 41%.	Water	58-63	putative DNA recombination protein Bet	Escherichia coli	13-16
8885834-8	1996	A total of seven tightly bound water molecules were found in the FGF-2 structure, two of which are located in the heparin binding site.	Water	31-36	fibroblast growth factor 2	Homo sapiens	65-70
8828472-9	1996	CRH (10(-8) M) suppressed the production of tritiated water (equivalent to estrogen production) from homogenates of rat granulosa cells incubated with a half-maximal concentration of FSH.	Water	54-59	corticotropin releasing hormone	Rattus norvegicus	0-3
8921199-0	1996	A lectin screening method for membrane glycoproteins: application to the human CHIP28 water channel (AQP-1).	Water	86-91	aquaporin 1 (Colton blood group)	Homo sapiens	101-106
8899896-11	1996	However, the physiological role of brain-derived AVP and Ang II in the control of water intake awaits further examination.	Water	82-87	angiotensinogen	Rattus norvegicus	57-63
8899900-6	1996	In evaluating the effect of antagonists to angiotensin II on the intake of water and NaCl in response to perturbations of hydromineral balance, difference in the route of administration of the stimulus and strain of the animals used must therefore be taken into account.	Water	75-80	angiotensinogen	Rattus norvegicus	43-57
8904632-4	1996	We conclude that angiotensin II is secreted into proximal tubular fluid and, in the anaesthetized rat, is maintained at a concentration that inhibits sodium and water transport via AT1 receptors.	Water	161-166	angiotensinogen	Rattus norvegicus	17-31
8899886-11	1996	Combining this approach with other methods allows cellular events in the brain to be related to the functional effects of Ang-II and its adaptive role in regulating water and salt metabolism.	Water	165-170	angiotensinogen	Rattus norvegicus	122-128
8899888-6	1996	Kininase II inhibitors, such as captopril, acutely potentiate drinking to Ang I, but after chronic exposure they may inhibit water intake.	Water	125-130	angiotensin I converting enzyme	Rattus norvegicus	0-11
8899891-1	1996	The physiological role of brain Ang II and acetylcholine in mediating water deprivation-induced drinking was assessed in male Sprague-Dawley rats.	Water	70-75	angiotensinogen	Rattus norvegicus	32-38
8899896-1	1996	It is now well recognized that systemically released angiotensin II (Ang II) and arginine vasopressin (AVP) act in concert in regulation of blood pressure and water-electrolyte balance.	Water	159-164	angiotensinogen	Rattus norvegicus	53-67
8899896-1	1996	It is now well recognized that systemically released angiotensin II (Ang II) and arginine vasopressin (AVP) act in concert in regulation of blood pressure and water-electrolyte balance.	Water	159-164	angiotensinogen	Rattus norvegicus	69-75
8899896-1	1996	It is now well recognized that systemically released angiotensin II (Ang II) and arginine vasopressin (AVP) act in concert in regulation of blood pressure and water-electrolyte balance.	Water	159-164	arginine vasopressin	Rattus norvegicus	90-101
21619279-2	1996	The nonpolar compounds (stearyl or butyl methacrylate) used for the introduction of hydrophobic ligands (C18, C4) are rendered water-soluble in the aqueous monomer mixture used for the synthesis of the matrix by the addition of a surfactant.	Water	127-132	Bardet-Biedl syndrome 9	Homo sapiens	105-108
8841131-2	1996	Secondary kH/kT kinetic isotope effects in H2O and kH/kT or kD/kT isotope effects in D2O have been measured for the triosephosphate isomerase-catalyzed conversion of dihydroxyacetone 3-phosphate (DHAP) to D-glyceraldehyde 3-phosphate.	Water	43-46	triosephosphate isomerase 1	Homo sapiens	116-141
8915966-8	1996	The benzenacetamide kappa agonist U-50488 had no effect on the response to 1 pM vasopressin but the kappa antagonist norbinaltorphimine significantly increased the effects of 1 pM vasopressin; this action was exerted earlier on in the initiation of water transport, as norbinaltorphimine did not affect the response to Sp-cAMPS, an activator of cAMP-dependent kinases.	Water	249-254	arginine vasopressin	Rattus norvegicus	180-191
8893027-1	1996	The C. elegans tax-4 mutants are abnormal in multiple sensory behaviors: they fail to respond to temperature or to water-soluble or volatile chemical attractants.	Water	115-120	Cyclic nucleotide-gated cation channel	Caenorhabditis elegans	15-20
8843907-12	1996	CONCLUSIONS: Neutralization of systemic TNF ameliorates EAU.	Water	56-59	tumor necrosis factor	Mus musculus	40-43
8923507-2	1996	administration of the kappa-opiate receptor agonist U 69.593 induces a rapid and short lasting suppression of oxytocin (OXT) levels in plasma of water deprived rats, whereas only a tendency towards a suppression of vasopressin (AVP) levels in plasma is observed.	Water	145-150	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	120-123
8914428-4	1996	Several mechanisms mediated by hyperinsulinemia can be entertained as follows: 1) sodium and water retention, 2) increased sympathetic nerve activity and reduced catecholamine clearance, 3) increased intracellular calcium concentration and reduced magnesium concentration, 4) increased coagulant activity and impaired fibrinolytic activity, 5) impaired endothelium-dependent NO synthesis and release, 6) increased vascular responsiveness for the vasoactive substrates, 7) increased proliferation of vascular smooth muscle cell by activation of protein kinase C or mediated by insulin and IGF-1 action.	Water	93-98	insulin	Homo sapiens	36-43
8874011-4	1996	Labeled SP-C adsorbed into the air-water interface in the company of the lipids.	Water	35-40	surfactant protein C	Homo sapiens	8-12
8887439-11	1996	The wave of S-phase synthesis and cell cycle progression returned to control levels in the H2O + CCl4 group by 60 hr but continued up to 72 hr in the ISOP + CCl4 group.	Water	91-94	C-C motif chemokine ligand 4	Rattus norvegicus	97-101
8794740-2	1996	The catalytic properties of wild-type murine CA V suggest the presence of a proton shuttle residue having pKa = 9.2, the role of which is to transfer a proton from zinc-bound water to solution in the hydration direction to regenerate the zinc hydroxide form of the enzyme.	Water	175-180	carbonic anhydrase 5a, mitochondrial	Mus musculus	45-49
8853387-8	1996	These data indicate that the vessels supplying the renal medullary circulation are sensitive within the range of plasma AVP concentrations observed with moderate water restriction.	Water	162-167	arginine vasopressin	Homo sapiens	120-123
9552306-1	1996	The mechanical strengths of oven-dried pellets of microcrystalline cellulose, MCC, prepared by extruder/marumerizer technology are weaker when ethanol/water mixtures are used as granulating solutions than when granulated with water.	Water	151-156	MCC regulator of WNT signaling pathway	Homo sapiens	78-81
9552306-1	1996	The mechanical strengths of oven-dried pellets of microcrystalline cellulose, MCC, prepared by extruder/marumerizer technology are weaker when ethanol/water mixtures are used as granulating solutions than when granulated with water.	Water	226-231	MCC regulator of WNT signaling pathway	Homo sapiens	78-81
8903111-4	1996	Plasma VIP concentrations increased slightly following the carbohydrate meal and following water loading.	Water	91-96	vasoactive intestinal peptide	Homo sapiens	7-10
8879347-3	1996	Responses to water immersion without epinephrine were characterized by significant suppression of plasma renin activity (PRA), plasma aldosterone concentration, and renal norepinephrine excretion, and an augmentation of natriuresis and diuresis.	Water	13-18	renin	Homo sapiens	105-110
8869414-15	1996	Parathyroid hormone, calcitriol and markers of bone resorption increased when patients were changed from the high-calcium, alkaline to the low-calcium drinking water.	Water	160-165	parathyroid hormone	Homo sapiens	0-19
21143281-7	1996	Circulating AngII acts on AT(1) receptors in the subfornical organ and organum vasculosum of the lamina terminalis (OVLT) to stimulate neurons that may have a role in initiating water drinking.	Water	178-183	angiotensinogen	Rattus norvegicus	12-17
21143283-2	1996	The effects of angiotensin II (AngII) on water and electrolyte transport are biphasic and dose-dependent, such that low concentrations (10(-12) to 10(-9) mol/L) stimulate reabsorption and high concentrations (10(-7) to 10(-6) mol/L) inhibit reabsorption.	Water	41-46	angiotensinogen	Homo sapiens	15-29
21143283-2	1996	The effects of angiotensin II (AngII) on water and electrolyte transport are biphasic and dose-dependent, such that low concentrations (10(-12) to 10(-9) mol/L) stimulate reabsorption and high concentrations (10(-7) to 10(-6) mol/L) inhibit reabsorption.	Water	41-46	angiotensinogen	Homo sapiens	31-36
8703203-3	1996	Recently, however, very strong evidence has been presented that the 28 kDa protein, CHIP28, found in the red cell membrane, is the locus of the water channel (see Agre et al., 1993).	Water	144-149	aquaporin 1 (Colton blood group)	Homo sapiens	84-90
8703203-4	1996	CHIP28 transports water very rapidly but does not transport small nonelectrolytes such as urea.	Water	18-23	aquaporin 1 (Colton blood group)	Homo sapiens	0-6
8703203-11	1996	Thus, the conclusion on irreversible thermodynamic and other grounds that urea and water share a common channel is in disagreement with the view that CHIP28 provides the sole channel for water entrance into the cell.	Water	187-192	aquaporin 1 (Colton blood group)	Homo sapiens	150-156
8890563-9	1996	The gene for water channel of erythrocyte is designated as AQP1 and is one of gene family, MIP, consisting of 20 genes.	Water	13-18	aquaporin 1 (Colton blood group)	Homo sapiens	59-63
8790265-2	1996	The renin-angiotensin-aldosterone system, the sympathetic nervous system, and arginine vasopressin are responsible for sodium and water retention in patients with cirrhosis.	Water	130-135	renin	Homo sapiens	4-9
8790265-2	1996	The renin-angiotensin-aldosterone system, the sympathetic nervous system, and arginine vasopressin are responsible for sodium and water retention in patients with cirrhosis.	Water	130-135	arginine vasopressin	Homo sapiens	87-98
22692140-2	1996	This laboratory has previously reported the simultaneous determination of eight water-soluble vitamin standards that is, B1, B2, B6, B12, C, niacin, niacinamide and folic acid.	Water	80-85	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	121-131
8873237-4	1996	In the presence of food, 1-10 micrograms neuropeptide Y produced a dose-dependent increase in food and water intake and serum insulin.	Water	103-108	neuropeptide Y	Rattus norvegicus	41-55
8873237-6	1996	In the absence of food, 1-20 micrograms neuropeptide Y produced a dose-dependent increase in water intake, whereas 1-5 micrograms produced a does-dependent increase in serum insulin.	Water	93-98	neuropeptide Y	Rattus norvegicus	40-54
8873245-1	1996	Previous reports indicate rats with lesions of the lateral parabrachial nucleus (IPBN) or lesions of the area postrema (AP) and adjacent nucleus of the solitary tract (NTS) consume abnormally large amounts of water after treatment with SC isoproterenol (ISOP) or angiotensin II.	Water	209-214	angiotensinogen	Rattus norvegicus	263-277
8752313-5	1996	The rates of formation of both hydrogen atoms and hydroxyl radicals were estimated to be equal to 25 microM min-1 in the sonolysis of pure water under argon.	Water	139-144	CD59 molecule (CD59 blood group)	Homo sapiens	108-113
8888443-6	1996	CONCLUSIONS: These results suggest that increased CGRP may play a role in the systemic vasodilatation in cirrhosis and may contribute to the abnormal distribution of the blood volume, which may lead to abnormal sodium and water handling.	Water	222-227	calcitonin related polypeptide alpha	Homo sapiens	50-54
8718890-6	1996	The ability of the three SHA oxygen atoms to closely duplicate the hydrogen-bonding pattern of these three water molecules in the native enzyme is postulated to account for the strong binding of this inhibitor to MPO.	Water	107-112	myeloperoxidase	Homo sapiens	213-216
8780523-3	1996	Evidence for Mn2+ as an electrophilic catalyst was supported by the observation that the nonenzymatic transfer of L-fucose from GDP-Fuc to the hydroxyl group of water in the presence of 10 mM MnCl2 at 20 degrees C was accelerated from K(obs)= 3.5 x 10(-6) to 3.8 x 10(-5) min-1.	Water	161-166	CD59 molecule (CD59 blood group)	Homo sapiens	272-277
8880739-6	1996	Water deprivation resulted in elevated basal intranuclear and plasma VP levels.	Water	0-5	arginine vasopressin	Rattus norvegicus	69-71
8880739-7	1996	Intraperitoneal hypertonic saline (HS) and direct osmotic stimulation of the SON increased VP release into the SON in both the control and water-deprived groups.	Water	139-144	arginine vasopressin	Rattus norvegicus	91-93
8718890-8	1996	Similarities in the hydrogen-bonding patterns of amino acid residues and water molecules in the distal heme pockets of myeloperoxidase and the nonhomologous cytochrome c peroxidase suggest that they may have similar mechanisms of compound I formation.	Water	73-78	myeloperoxidase	Homo sapiens	119-134
8718890-8	1996	Similarities in the hydrogen-bonding patterns of amino acid residues and water molecules in the distal heme pockets of myeloperoxidase and the nonhomologous cytochrome c peroxidase suggest that they may have similar mechanisms of compound I formation.	Water	73-78	cytochrome c, somatic	Homo sapiens	157-169
8770171-3	1996	At doses &gt; or = 1 microM, dopamine inhibited arginine vasopressin (AVP)-dependent Na+ and water transport (measured by the unidirectional lumen-to-bath 22Na+ flux and the transepithelial voltage) and osmotic water permeability (Pf).	Water	93-98	arginine vasopressin	Rattus norvegicus	57-68
8765133-11	1996	Temperature-induced phase separation was studied with EO30/PO70 at 45 degrees C. Both BSA and lysozyme were completely partitioned to the water phase formed above the cloud point of EO30/PO70.	Water	138-143	lysozyme	Homo sapiens	94-102
8698857-7	1996	In other experiments, water deprivation increased cGK II mRNA and protein three to fourfold in the inner medulla where both cGK II, and a kidney specific CI- channel shown by others to be regulated by dehydration, are localized in the ATL.	Water	22-27	protein kinase cGMP-dependent 2	Rattus norvegicus	50-56
15048380-1	1996	Suppressed ion chromatography has been applied to the determination of S(IV) species in cloud and fog water in the range 0.012-2.4 mg S(IV)-S/L.	Water	102-107	zinc finger protein, FOG family member 1	Homo sapiens	98-101
8698857-7	1996	In other experiments, water deprivation increased cGK II mRNA and protein three to fourfold in the inner medulla where both cGK II, and a kidney specific CI- channel shown by others to be regulated by dehydration, are localized in the ATL.	Water	22-27	protein kinase cGMP-dependent 2	Rattus norvegicus	124-130
8764602-3	1996	Because PUT-SOD had the highest PS values, SOD was modified in the present experiments by activating carboxylic acid groups to the reactive ester with water-soluble carbodiimide and then reacted with PUT as the nucleophilic reagent.	Water	151-156	superoxide dismutase 1	Homo sapiens	12-15
8877703-2	1996	The results of a series of molecular dynamics simulations of methane in SPC/E water at different temperatures are reported.	Water	78-83	proline rich protein gene cluster	Homo sapiens	72-75
8764602-3	1996	Because PUT-SOD had the highest PS values, SOD was modified in the present experiments by activating carboxylic acid groups to the reactive ester with water-soluble carbodiimide and then reacted with PUT as the nucleophilic reagent.	Water	151-156	superoxide dismutase 1	Homo sapiens	43-46
8840909-2	1996	Ang II infusion in alcohol-naive mice increased daily water intake from 3.7 +/- 0.2 ml (mean +/- SE, n = 6) to 11.0 +/- 1.5 ml on day 4 (p &lt; 0.001) and to 18.3 +/- 2.6 ml on day 8 (p &lt; 0.001).	Water	54-59	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
8840263-11	1996	However, when plasma from Li-treated PTX rats was used, the AVP induced increase in water permeability (54.7 +/- 11.2%) was not significantly different from that observed in PTX control rats.	Water	84-89	arginine vasopressin	Rattus norvegicus	60-63
8865303-12	1996	CONCLUSIONS: The decomposition of human insulin in lyophilized powders between pH 3-5 is a water induced solid-state reaction accelerated by the plasticization effect of sorbed water.	Water	91-96	insulin	Homo sapiens	40-47
8865303-12	1996	CONCLUSIONS: The decomposition of human insulin in lyophilized powders between pH 3-5 is a water induced solid-state reaction accelerated by the plasticization effect of sorbed water.	Water	177-182	insulin	Homo sapiens	40-47
8692933-5	1996	Water (ice) was recognized early as a potential matrix because of its strong O-H stretching mode near 3 microm.	Water	0-5	carboxylesterase 2	Homo sapiens	7-10
8755733-4	1996	Thermodynamic analysis of the data shows that the transfer of the peptides from water into bilayers at 298 K is driven by the entropic term (-T delta Str) with values ranging from -6.7 to -10 kcal mol-1, opposed by the enthalpic term (delta Htr) by approximately 4 kcal mol-1, and accompanied by a change in heat capacity (delta Cp) ranging from -117 to -208 cal K-1 mol-1.	Water	80-85	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	197-202
8755733-4	1996	Thermodynamic analysis of the data shows that the transfer of the peptides from water into bilayers at 298 K is driven by the entropic term (-T delta Str) with values ranging from -6.7 to -10 kcal mol-1, opposed by the enthalpic term (delta Htr) by approximately 4 kcal mol-1, and accompanied by a change in heat capacity (delta Cp) ranging from -117 to -208 cal K-1 mol-1.	Water	80-85	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	270-275
8755733-4	1996	Thermodynamic analysis of the data shows that the transfer of the peptides from water into bilayers at 298 K is driven by the entropic term (-T delta Str) with values ranging from -6.7 to -10 kcal mol-1, opposed by the enthalpic term (delta Htr) by approximately 4 kcal mol-1, and accompanied by a change in heat capacity (delta Cp) ranging from -117 to -208 cal K-1 mol-1.	Water	80-85	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	270-275
8693005-6	1996	Mechanisms integrated in the hypothalamus (the evolutionary ancient midbrain) control water retention and facilitate excretion of sodium, and also control the secretion of renin by the kidney.	Water	86-91	renin	Homo sapiens	172-177
8660611-4	1996	GSL containing silica gel was scraped off and extracted with chloroform:methanol:water (30:60:8, by vol).	Water	81-86	cathepsin A	Homo sapiens	0-3
8686761-5	1996	Quantitation of aromatase activity with the tritiated water method demonstrated 41.62 +/- 9.15 pmol/hour/mg protein in 11 ovarian carcinomas.	Water	54-59	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	16-25
8836324-0	1996	Angiotensin II reduces alcohol intake and choice in water- or food-restricted rats.	Water	52-57	angiotensinogen	Rattus norvegicus	0-14
8836324-6	1996	Following adaptation, rats were randomly assigned to receive IP saline or 200 micrograms/kg of AII prior to presentation of a choice of ethanol or water for 1 h. AII reduced ethanol intake and increased water intake at 0-30 min after injection.	Water	147-152	angiotensinogen	Rattus norvegicus	162-165
8836324-6	1996	Following adaptation, rats were randomly assigned to receive IP saline or 200 micrograms/kg of AII prior to presentation of a choice of ethanol or water for 1 h. AII reduced ethanol intake and increased water intake at 0-30 min after injection.	Water	203-208	angiotensinogen	Rattus norvegicus	162-165
8760244-1	1996	Aquaporin-2 (AQP-2) is the arginine vasopressin-regulated water channel of the renal collecting ducts.	Water	58-63	arginine vasopressin	Rattus norvegicus	36-47
11666563-3	1996	AcMP8 is the Cys-14-acetylated water-soluble heme-octapeptide fragment obtained proteolytically from cytochrome c.	Water	31-36	cytochrome c, somatic	Homo sapiens	101-113
8760258-1	1996	Aquaporin-1 (AQP1), located in proximal tubules (PT) and descending thin limbs of Henle (DTL), and aquaporin-2 (AQP2), located in collecting ducts (CD), are channels involved in water transport across renal tubule epithelia.	Water	178-183	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
8673608-2	1996	Cytochrome P450eryF is unusual in having alanine in place of this threonine and an ordered active site water molecule (Wat 519) which is hydrogen bonded to the substrate 5-hydroxyl group and is in position to operate as an acid catalyst required for cleaving dioxygen.	Water	103-108	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
8865375-7	1996	This could be due to the significantly reduced amount of azosemide excreted in 12 h urine, significantly higher plasma osmolarity, and increased blood vasopressin concentration in the water-deprived rats.	Water	184-189	arginine vasopressin	Rattus norvegicus	151-162
8828810-1	1996	The involvement of protein kinase C (PKC) in vasopressin-induced effects on renal water reabsorption is still unresolved.	Water	82-87	vasopressin	Sus scrofa	45-56
8675685-1	1996	Systemic and/or locally produced angiotensin II stimulates salt and water reabsorption in the renal proximal tubule.	Water	68-73	angiotensinogen	Rattus norvegicus	33-47
8675687-3	1996	In this paper, we demonstrate that the arcades are a site of expression of two proteins, aquaporin-2 (the vasopressin-regulated water channel) and the V2 vasopressin receptor, that are important to regulated water transport in the kidney.	Water	128-133	arginine vasopressin	Rattus norvegicus	106-117
8675687-3	1996	In this paper, we demonstrate that the arcades are a site of expression of two proteins, aquaporin-2 (the vasopressin-regulated water channel) and the V2 vasopressin receptor, that are important to regulated water transport in the kidney.	Water	128-133	arginine vasopressin	Rattus norvegicus	154-165
8675687-3	1996	In this paper, we demonstrate that the arcades are a site of expression of two proteins, aquaporin-2 (the vasopressin-regulated water channel) and the V2 vasopressin receptor, that are important to regulated water transport in the kidney.	Water	208-213	arginine vasopressin	Rattus norvegicus	106-117
8675687-3	1996	In this paper, we demonstrate that the arcades are a site of expression of two proteins, aquaporin-2 (the vasopressin-regulated water channel) and the V2 vasopressin receptor, that are important to regulated water transport in the kidney.	Water	208-213	arginine vasopressin	Rattus norvegicus	154-165
8675687-8	1996	Thus, these results indicate that the arcades contain the specific proteins associated with vasopressin-regulated water transport, and may be a heretofore unrecognized site of free water absorption.	Water	114-119	arginine vasopressin	Rattus norvegicus	92-103
8675687-8	1996	Thus, these results indicate that the arcades contain the specific proteins associated with vasopressin-regulated water transport, and may be a heretofore unrecognized site of free water absorption.	Water	181-186	arginine vasopressin	Rattus norvegicus	92-103
8675692-4	1996	In terminal IMCDs, arginine vasopressin (AVP)-stimulated osmotic water permeability was significantly reduced in rats fed 8% protein compared to rats fed 18% protein.	Water	65-70	arginine vasopressin	Rattus norvegicus	28-39
8675692-4	1996	In terminal IMCDs, arginine vasopressin (AVP)-stimulated osmotic water permeability was significantly reduced in rats fed 8% protein compared to rats fed 18% protein.	Water	65-70	arginine vasopressin	Rattus norvegicus	41-44
8675692-5	1996	In initial IMCDs, AVP-stimulated osmotic water permeability was unaffected by dietary protein.	Water	41-46	arginine vasopressin	Rattus norvegicus	18-21
8675692-6	1996	Thus, AVP-stimulated osmotic water permeability is significantly reduced in terminal IMCDs but not in initial IMCDs.	Water	29-34	arginine vasopressin	Rattus norvegicus	6-9
8675692-7	1996	Next, we determined if the amount of immunoreactive aquaporin-2 (AQP2, the AVP-regulated water channel) or AQP3 protein was altered.	Water	89-94	arginine vasopressin	Rattus norvegicus	75-78
8675692-11	1996	Together, the results suggest that the decrease in AVP-stimulated osmotic water permeability results, at least in part, in the decrease in AQP2 protein.	Water	74-79	arginine vasopressin	Rattus norvegicus	51-54
8676388-1	1996	Molecular dynamics simulations with umbrella sampling are used to perform free energy simulations of C-terminal and N-terminal helix propagation in small helices of Ace-(Ala)n-NMe, with n= (4,5,10,15), in water.	Water	205-210	angiotensin I converting enzyme	Homo sapiens	165-168
8664315-6	1996	An 11-fold increase in 5-methyltetrahydrofolate (5-MTHF) uptake was observed in oocytes injected with 10 ng IFC1(RFC1) cRNA compared to water-injected controls.	Water	136-141	replication factor C (activator 1) 1	Mus musculus	113-117
8679526-19	1996	As in the ecDHFR dideazatetrahydrofolate complex, in both the P6(1) and P6(5) structures a water molecule bridges pteridine O4 and Trp-22(N epsilon 1) with ideal geometry for hydrogen bonding, perhaps contributing to the slow release of 5,6,7,8-tetrahydrofolate from the enzyme-product complex.	Water	91-96	dihydrofolate reductase	Escherichia coli	10-16
8654144-2	1996	A water extract of H. pylori that was prepared from biopsy materials obtained from a patient with gastric ulcer increased the surface expression of CD18 on human neutrophils isolated from peripheral blood, the adhesion of neutrophil-endothelial cells, and the production of active oxygen species by neutrophils.	Water	2-7	integrin subunit beta 2	Homo sapiens	148-152
8793299-3	1996	PLD can use primary alcohols in preference to water during the hydrolytic step, generating the corresponding phosphatidylalcohol instead of PA, its normal product.	Water	46-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
8753021-8	1996	In river water, CNP was degraded rapidly and converted to amino-CNP.	Water	9-14	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	16-19
8753021-8	1996	In river water, CNP was degraded rapidly and converted to amino-CNP.	Water	9-14	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	64-67
8753021-9	1996	Change in mutagenicity of river water to which CNP was added seemed to reflect changes in amino-CNP concentration in river water.	Water	32-37	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	47-50
8753021-9	1996	Change in mutagenicity of river water to which CNP was added seemed to reflect changes in amino-CNP concentration in river water.	Water	32-37	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	96-99
8753021-9	1996	Change in mutagenicity of river water to which CNP was added seemed to reflect changes in amino-CNP concentration in river water.	Water	123-128	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	47-50
8753021-9	1996	Change in mutagenicity of river water to which CNP was added seemed to reflect changes in amino-CNP concentration in river water.	Water	123-128	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	96-99
8793792-4	1996	The only difference between groups thus concerned the water intake-vasopressin axis.	Water	54-59	arginine vasopressin	Rattus norvegicus	67-78
8856149-0	1996	An NMR, CD, molecular dynamics and fluorometric study of the conformation of bradykinin antagonists B9340, B9430, B9436 and B9452 in water and in aqueous micellar solutions.	Water	133-138	kininogen 1	Homo sapiens	77-87
8743462-5	1996	We have shown that both parameters do increase when normal rats are submitted to chronic alterations in the water intake/vasopressin axis within the normal range of physiologic regulation.	Water	108-113	arginine vasopressin	Rattus norvegicus	121-132
8731216-2	1996	In this study, insulin was covalently attached to two water-soluble polymers containing N-(2-hydroxypropyl)methacrylamide using the mixed anhydride method.	Water	54-59	insulin	Homo sapiens	15-22
8642417-0	1996	Endogenous substance P mediates cold water stress-induced increase in interleukin-6 secretion from peritoneal macrophages.	Water	37-42	interleukin 6	Mus musculus	70-83
8642417-3	1996	The stress paradigm involved subjecting male C57BL/6J mice to 5 min swim tests in 10 +/- 2 degrees C water twice daily for 4 d. Cold water stress augments the lipopolysaccharide-induced IL-6 secretion from peritoneal macrophages, elevates immunoreactive SP (iSP) in the peritoneal wash fluid, and reduces iSP in certain peritoneum-containing tissues or organs (i.e., diaphragm, abdominal wall, ileum, and rectum).	Water	101-106	interleukin 6	Mus musculus	186-190
8642417-3	1996	The stress paradigm involved subjecting male C57BL/6J mice to 5 min swim tests in 10 +/- 2 degrees C water twice daily for 4 d. Cold water stress augments the lipopolysaccharide-induced IL-6 secretion from peritoneal macrophages, elevates immunoreactive SP (iSP) in the peritoneal wash fluid, and reduces iSP in certain peritoneum-containing tissues or organs (i.e., diaphragm, abdominal wall, ileum, and rectum).	Water	133-138	interleukin 6	Mus musculus	186-190
8642417-6	1996	Moreover, RP67,580, a specific SP antagonist, eliminates the cold water stress-induced augmentation of IL-6 secretion from peritoneal macrophages.	Water	66-71	interleukin 6	Mus musculus	103-107
8743482-2	1996	Together with the recent cloning of the vasopressin-regulated water channel in the apical membrane of the collecting duct tubule and of the identification of rare autosomal recessive nephrogenic diabetes insipidus patients with mutations in the AQP2 gene, these developments enable carrier detection and early diagnosis of infants with congenital nephrogenic diabetes insipidus.	Water	62-67	arginine vasopressin	Homo sapiens	40-51
8743483-6	1996	Short-term regulation of collecting duct water permeability by vasopressin is largely a consequence of regulated trafficking of AQP2-containing vesicles to and from the apical plasma membrane.	Water	41-46	arginine vasopressin	Homo sapiens	63-74
8643603-6	1996	Immunoblots demonstrated RUT labeling in both plasma membrane and intracellular vesicle-enriched membrane fractions from inner medulla, a subcellular distribution similar to that of the vasopressin-regulated water channel, aquaporin-2.	Water	208-213	arginine vasopressin	Rattus norvegicus	186-197
12226294-2	1996	CaM mRNA levels increased rapidly and transiently following incubation of aleurone layers in H2O, CaCl2, or GA3.	Water	93-96	calmodulin	Hordeum vulgare	0-3
8646535-3	1996	We report here the results of water (17)O and (2)H magnetic relaxation dispersion measurements on wild-type and mutant bovine pancreatic trypsin inhibitor in aqueous solution at 4-80 degrees C. These data lead to the first determination of the exchange rate of a water molecule buried in a protein.	Water	30-35	trophoblast Kunitz domain protein 1	Bos taurus	137-154
8646535-3	1996	We report here the results of water (17)O and (2)H magnetic relaxation dispersion measurements on wild-type and mutant bovine pancreatic trypsin inhibitor in aqueous solution at 4-80 degrees C. These data lead to the first determination of the exchange rate of a water molecule buried in a protein.	Water	263-268	trophoblast Kunitz domain protein 1	Bos taurus	137-154
8627387-4	1996	The present study was designed to evaluate the efforts of NGF on recent memory in a task that used escape from water as the motivating stimulus and used the same design as forced-choice recognition tasks given to humans.	Water	111-116	nerve growth factor	Homo sapiens	58-61
11666533-1	1996	A theoretical framework is presented for analysis of all three "multiline" EPR spectra (MLS) arising from the tetramanganese (Mn(4)) cluster in the S(2) oxidation state of the photosynthetic water oxidizing complex (WOC).	Water	191-196	holocytochrome c synthase	Homo sapiens	88-91
8634257-4	1996	We have characterized the hydrodynamic properties of Triton X-100 solubilized peripherin/rds-rom-1 complexes from bovine ROS membranes by gel exclusion chromatography on Sepharose C1-6B and velocity sedimentation through H2O- and D2O-based sucrose gradients.	Water	221-224	peripherin	Bos taurus	78-88
8928911-5	1996	An intravenous infusion of ANG II in Cap-blocked rats brought MAP into the normal range and elicited water and salt drinking within 90 min.	Water	101-106	angiotensinogen	Rattus norvegicus	27-33
8671659-2	1996	Mice were continuously exposed to ovalbumin in their drinking water for a minimal period of 20 days and then immunized against antigen in either complete Freund"s adjuvant or Al(OH)3.	Water	62-67	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	34-43
8630079-4	1996	We concluded that ferric Cyt c produced some radical species from water-soluble oxygen in the presence of CL (CL-Cyt c system) and that radicals oxidized free LA or CL.	Water	66-71	cytochrome c, somatic	Homo sapiens	25-30
9065138-7	1996	RESULTS: In 1-deamino-[8-D-arginine] vasopressin-treated women, maternal urine flow increased with oral water loading, decreased with 1-deamino-[8-D-arginine] vasopressin administration, and remained reduced for 8 hours.	Water	104-109	arginine vasopressin	Homo sapiens	37-48
8625684-14	1996	The role of ANF in the water and salt retention induced by MV with PEEP might be limited to hypervolemic conditions.	Water	23-28	natriuretic peptide A	Homo sapiens	12-15
8933206-10	1996	Stimulation with a sonicated B. burgdorferi preparation in the presence of the water-soluble compound Prednisolone-21-hemisuccinate considerably reduced expression of ICAM-1, and marginally also of E-selectin, whereas the level of P-selectin and VCAM-1 remained unaltered.	Water	79-84	selectin, endothelial cell	Mus musculus	198-208
8928911-7	1996	Sodium and water balances tended to be more positive during ANG II than during phenylephrine infusions.	Water	11-16	angiotensinogen	Rattus norvegicus	60-66
8933206-10	1996	Stimulation with a sonicated B. burgdorferi preparation in the presence of the water-soluble compound Prednisolone-21-hemisuccinate considerably reduced expression of ICAM-1, and marginally also of E-selectin, whereas the level of P-selectin and VCAM-1 remained unaltered.	Water	79-84	selectin, platelet	Mus musculus	231-241
8933210-0	1996	Augmentation of tumor immunity by 6-MPG, a water-soluble derivative of 6-mercaptopurine, in mice.	Water	43-48	N-methylpurine-DNA glycosylase	Mus musculus	36-39
8725148-8	1996	The PCB uptake in Caco-2 cells exceeded the uptake as expected from monomer diffusion only, indicating that bile salt micelles facilitate the PCB transport over the unstirred water layer.	Water	175-180	pyruvate carboxylase	Homo sapiens	4-7
8605210-1	1996	In bee venom phospholipase A2, histidine-34 probably functions as a Bronsted base to deprotonate the attacking water.	Water	111-116	phospholipase A2 group IB	Homo sapiens	13-29
8611526-12	1996	This effect is attributed to loss of water from the hydration shell of the insulin hexamer with increasing temperature and consequently reduces the entropic contributions to the T &lt;--&gt; R transition in the phenol/2Zn(II)-insulin hexamer system.	Water	37-42	insulin	Homo sapiens	75-82
8611526-12	1996	This effect is attributed to loss of water from the hydration shell of the insulin hexamer with increasing temperature and consequently reduces the entropic contributions to the T &lt;--&gt; R transition in the phenol/2Zn(II)-insulin hexamer system.	Water	37-42	insulin	Homo sapiens	226-233
8797177-1	1996	Recent studies indicate that centrally released arginine vasopressin (AVP) facilitates brain water permeability in normal and pathological conditions.	Water	93-98	arginine vasopressin	Rattus norvegicus	57-68
8738251-0	1996	Role of the alpha 1-, and alpha 2- and beta-adrenoceptors of the median preoptic area on the water intake, renal excretion, and arterial pressure induced by ANG II.	Water	93-98	angiotensinogen	Homo sapiens	157-163
8738251-2	1996	Prazosin (an alpha 1-adrenergic receptor antagonist) and yohimbine (an alpha 2-adrenergic receptor antagonist) antagonized the water ingestion, Na+, K+, and urine excretion induced by ANG II.	Water	127-132	angiotensinogen	Homo sapiens	184-190
11666437-2	1996	The molecular composition of a transient green intermediate generated from [Fe(2)O(5-Me(3)-TPA)(2)(OH)(H(2)O)](ClO(4))(3) with H(2)O(2) in CH(3)CN at -40 degrees C was determined by introducing the solution via a precooled syringe to the inlet of the mass spectrometer.	Water	103-109	plasminogen activator, tissue type	Homo sapiens	91-94
8928752-2	1996	This includes such examples as gramicidin A, the proximal tubule basolateral membrane, and the aquaporin 1 (CHIP28) water channel.	Water	116-121	aquaporin 1 (Colton blood group)	Homo sapiens	95-106
8928752-2	1996	This includes such examples as gramicidin A, the proximal tubule basolateral membrane, and the aquaporin 1 (CHIP28) water channel.	Water	116-121	aquaporin 1 (Colton blood group)	Homo sapiens	108-114
8928752-10	1996	This limiting condition corresponds to a water channel completely filled by water and may be applicable to the aquaporin 1 water channel.	Water	41-46	aquaporin 1 (Colton blood group)	Homo sapiens	111-122
8928752-10	1996	This limiting condition corresponds to a water channel completely filled by water and may be applicable to the aquaporin 1 water channel.	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	111-122
8928752-10	1996	This limiting condition corresponds to a water channel completely filled by water and may be applicable to the aquaporin 1 water channel.	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	111-122
8829535-2	1996	Drinking deaerated water decreased the levels of serum alkaline phosphatase (SAP) and serum urea nitrogen (SUN), and increased the serum potassium (SK) and serum phosphorus (SP) levels.	Water	19-24	amyloid P component, serum	Rattus norvegicus	77-80
8967344-0	1996	Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney.	Water	87-92	arginine vasopressin	Rattus norvegicus	59-70
8967344-2	1996	In this study, we examined the effect of BUO and release of BUO on the expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2) in rat kidney.	Water	111-116	arginine vasopressin	Rattus norvegicus	89-100
8931343-1	1996	Renin-angiotensin system plays a prominent role in the sodium and water homeostasis.	Water	66-71	renin	Homo sapiens	0-5
8736116-4	1996	The water intake induced by injection of ANG II and water deprivation was also reduced from 9.2 +/- 1.4 and 12.7 +/- 1.4 ml/h to 0.8 +/- 0.2 and 1.7 +/- 0.3 ml/h (N = 6 and N = 8), respectively.	Water	4-9	angiotensinogen	Rattus norvegicus	41-47
8736116-5	1996	These data indicate a correlation between noradrenergic pathways and angiotensinergic receptors and lead us to conclude that noradrenaline-induced water intake may be due to the release of ANG II by the brain.	Water	147-152	angiotensinogen	Rattus norvegicus	189-195
8736116-6	1996	The finding that water intake was reduced by DUP-753 in water-deprived animals suggests that dehydration releases ANG II, and that AT1 receptors of the brain play an important role in the regulation of water intake induced by deprivation.	Water	17-22	angiotensinogen	Rattus norvegicus	114-120
8717071-4	1996	Endothelins inhibit vasopressin-stimulated cAMP accumulation and water reabsorption in the collecting duct; endothelins may also inhibit sodium reabsorption in the proximal tubule and collecting duct.	Water	65-70	arginine vasopressin	Homo sapiens	20-31
8717072-6	1996	Endothelin can inhibit sodium reabsorption and, in the rat, vasopressin-induced water transport.	Water	80-85	arginine vasopressin	Rattus norvegicus	60-71
8634085-3	1996	We now report further characterization of the full-length OS-9 cDNA sequence consists of 2785 bp from which an open reading frame (ORF) with 667 amino-acid residues was deduced, The predicted polypeptide was water soluble and acidic.	Water	208-213	OS9 endoplasmic reticulum lectin	Homo sapiens	58-62
8839452-2	1996	Exposure of the membrane-bound RyR to the water soluble carboxyl reagents 1-ethyl-3 (3-(dimethylamino) propyl carbodiimide (EDC) or N-ethyl-pheny-lisoxazolium-3"-sulfonate (WRK) only slightly affects their ryanodine binding capacity.	Water	42-47	ryanodine receptor 1	Homo sapiens	31-34
8778848-8	1996	The greater water consumption in females is consistent with other studies demonstrating sex differences in plasma vasopressin levels, as well as differences in vasopressin sensitivity.	Water	12-17	arginine vasopressin	Rattus norvegicus	114-125
8778848-8	1996	The greater water consumption in females is consistent with other studies demonstrating sex differences in plasma vasopressin levels, as well as differences in vasopressin sensitivity.	Water	12-17	arginine vasopressin	Rattus norvegicus	160-171
8738333-6	1996	The procedure has been applied to the quantitation of a recently identified protein, aquaporin (CHIP28), assumed to be a major water channel in the red blood cell membrane.	Water	127-132	aquaporin 1 (Colton blood group)	Homo sapiens	96-102
11536750-1	1996	The reaction of iron sulfide (FeS) with H2S in water, in presence of CO2 under anaerobic conditions was found to yield H2 and a variety of organic sulfur compounds, mainly thiols and small amounts of CS2 and dimethyldisulfide.	Water	47-52	chorionic somatomammotropin hormone 2	Homo sapiens	200-203
8931343-3	1996	Theoretically, administering of angiotensin converting enzyme inhibitors can enhance sodium and water retention in cirrhotic patients with ascites.	Water	96-101	angiotensin I converting enzyme	Homo sapiens	32-61
8630383-8	1996	In addition, cross-linking studies using a water-soluble cross linking reagent bis-sulfosuccinimidyl-suberate showed that immobilized YB5.B8 MoAb induced dimerization and activation of KIT.	Water	43-48	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	185-188
22097391-3	1996	First, PL D hydrolysis of stable 1,2-diacyl-sn-glycero-3-phosphocholine (PC) films by PL D generated a stable 1,2-diacyl-sn-glycero-3-phosphate (PA) film and water-soluble choline.	Water	158-163	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	7-11
22097391-3	1996	First, PL D hydrolysis of stable 1,2-diacyl-sn-glycero-3-phosphocholine (PC) films by PL D generated a stable 1,2-diacyl-sn-glycero-3-phosphate (PA) film and water-soluble choline.	Water	158-163	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	86-90
8632435-0	1996	An NMR, CD, molecular dynamics, and fluorometric study of the conformation of the bradykinin antagonist B-9340 in water and in aqueous micellar solutions.	Water	114-119	kininogen 1	Homo sapiens	82-92
8619400-1	1996	We have previously shown that humic acid (well-water humic acid, HA, and synthetic humic acid, SHA) enhances cell surface expression of tissue factor (TF).	Water	47-52	coagulation factor III, tissue factor	Canis lupus familiaris	136-149
11666389-0	1996	Oxidation Kinetics of the Potent Insulin Mimetic Agent Bis(maltolato)oxovanadium(IV) (BMOV) in Water and in Methanol.	Water	95-100	insulin	Homo sapiens	33-40
8814646-6	1996	Water shifted the P-31 resonant frequency of DPPC downfield, and the effect magnitude varied with water concentration.	Water	0-5	ATPase H+ transporting V1 subunit E1	Homo sapiens	18-22
8814646-6	1996	Water shifted the P-31 resonant frequency of DPPC downfield, and the effect magnitude varied with water concentration.	Water	98-103	ATPase H+ transporting V1 subunit E1	Homo sapiens	18-22
8619400-1	1996	We have previously shown that humic acid (well-water humic acid, HA, and synthetic humic acid, SHA) enhances cell surface expression of tissue factor (TF).	Water	47-52	coagulation factor III, tissue factor	Canis lupus familiaris	151-153
8851540-8	1996	In Experiment 3, monkeys obtained food or saccharin by pressing keys; the fixed ratio of presses per food pellet was increased once when tap water was each monkey"s only source of fluid, again when each monkey"s water was sweetened with saccharin, and a third time when each monkey had concurrent access to the saccharin solution and plain water.	Water	141-146	nuclear RNA export factor 1	Rattus norvegicus	137-140
8780219-1	1996	Our previous demonstration of sexual dimorphism in the antidiuretic response to exogenous vasopressin prompted us to investigate the response to moderately high levels of endogenous vasopressin stimulated by water deprivation in conscious rats.	Water	208-213	arginine vasopressin	Rattus norvegicus	182-193
8780219-3	1996	Plasma concentrations of vasopressin were higher in females than in males after water deprivation, but plasma osmolality did not differ.	Water	80-85	arginine vasopressin	Rattus norvegicus	25-36
8733900-2	1996	Arginine-vasopressin (AVP) is involved in the regulation of several centrally mediated events such as modulation of fever and the ease with which water permeates into and out of the brain.	Water	146-151	arginine vasopressin	Homo sapiens	0-20
8733900-2	1996	Arginine-vasopressin (AVP) is involved in the regulation of several centrally mediated events such as modulation of fever and the ease with which water permeates into and out of the brain.	Water	146-151	arginine vasopressin	Homo sapiens	22-25
8963438-8	1996	In the frontal and parietal cortex, a significant correlation occurred between the latency to find the invisible platform in the water maze and somatostatin mRNA (r = -0.54 and 0.59 respectively, P &lt; 0.02).	Water	129-134	somatostatin	Rattus norvegicus	144-156
8704108-1	1996	This study was designed to assess whether contrast-enhanced dynamic 1H magnetic resonance imaging (DMRI) can be used to detect the effects of the loop diuretic furosemide and the vasoactive peptide angiotensin II on tubular water reabsorption in the rat kidney.	Water	224-229	angiotensinogen	Rattus norvegicus	198-212
8643669-4	1996	The multiphasic kinetics in cytochrome c oxidase can largely be attributed to the presence Of CuA as the donor of a fourth electron, which rereduces the originally oxidized low-spin heme and completes the reduction of O2 to water.	Water	224-229	cytochrome c, somatic	Homo sapiens	28-40
8868478-3	1996	The structure of the active site part of the inhibitor shows a network of water molecules connecting both the side-chain and backbone atoms of thrombin and the inhibitor.	Water	74-79	coagulation factor II, thrombin	Homo sapiens	143-151
15157485-4	1996	Some activator proteins bind to GSLs and form water-soluble complexes, which lift out of the membrane and give the water-soluble hydrolysing enzymes access to the regions of the GSL that would otherwise be obscured by the membrane.	Water	46-51	cathepsin A	Homo sapiens	32-35
15157485-4	1996	Some activator proteins bind to GSLs and form water-soluble complexes, which lift out of the membrane and give the water-soluble hydrolysing enzymes access to the regions of the GSL that would otherwise be obscured by the membrane.	Water	115-120	cathepsin A	Homo sapiens	32-35
8626743-0	1996	Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.	Water	0-5	amyloid beta precursor protein	Homo sapiens	14-19
8626743-1	1996	Ultracentrifugation and graded molecular sieving, as well as a sensitive sandwich enzyme-linked immunosorbent assay were used to isolate and quantitate the amounts of water-soluble oligomers of beta amyloid (Abeta) peptides N-40 and N-42 in cerebral cortex of normal and Alzheimer disease (AD) brains.	Water	167-172	amyloid beta precursor protein	Homo sapiens	208-213
8626743-2	1996	AD brains contained 6-fold more water-soluble Abeta (wsAbeta) than control brains.	Water	32-37	amyloid beta precursor protein	Homo sapiens	46-51
8626743-10	1996	Therefore, it is likely that the water-soluble Abeta peptides we quantified are precursors to its insoluble, filamentous form.	Water	33-38	amyloid beta precursor protein	Homo sapiens	47-52
8772586-0	1996	Short-term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure.	Water	104-109	growth hormone 1	Homo sapiens	11-25
8772586-0	1996	Short-term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure.	Water	104-109	growth hormone 1	Homo sapiens	27-29
8594192-8	1996	In the case of thrombin, the water molecule singled out by valence calculations is, in fact, a bound Na ion as demonstrated by molecular replacement with Rb+.	Water	29-34	coagulation factor II, thrombin	Homo sapiens	15-23
8652550-9	1996	Of the added solvent groups, five ordered water molecules are conserved in each of the four independent structures of human aFGF.	Water	42-47	fibroblast growth factor 1	Homo sapiens	124-128
8674648-0	1996	FTIR spectroscopic structural analysis of the CHIP28 water channel protein.	Water	53-58	aquaporin 1 (Colton blood group)	Homo sapiens	46-52
8629540-1	1996	Pharmacologic agents that attenuate the influence of the renin-angiotensin-aldosterone system are known to reduce systemic arterial blood pressure through vasodilatory action and enhanced renal clearance of sodium and water.	Water	218-223	renin	Homo sapiens	57-62
8819827-3	1996	With the developed procedure, the nerve agents sarin, tabun, soman, DFP and VX can be determined in freshly prepared water samples at ppt levels.	Water	117-122	tachykinin precursor 1	Homo sapiens	134-137
8575077-4	1996	Recombinant human IL-2 (10(6) U IV per rat, n = 6) elevated lung water, myeloperoxidase activity, and protein accumulation in bronchoalveolar lavage fluid and induced tissue hypoxia.	Water	65-70	interleukin 2	Homo sapiens	18-22
8731356-6	1996	The AT1 receptor antagonist DUP-753 (50 nmol/microliters) injected into the LV reduced water intake induced by ANG II (10 nmol/microliters) from 9.2 +/- 1.4 to 0.4 +/- 0.1 ml/h (N = 8), and water intake induced by carbachol (2 nmol/microliters) from 9.8 +/- 1.4 ml/h to 3.7 +/- 0.8 ml/h (N = 8).	Water	87-92	angiotensinogen	Rattus norvegicus	111-117
8734306-2	1996	RESULTS: VIP-stimulated net water flux was efficiently inhibited by both peptides at all three intestinal levels studied; PYY (ID50 about 30 pmol/kg.h) was 3 to 18 fold more potent than NPY.	Water	28-33	vasoactive intestinal peptide	Rattus norvegicus	9-12
8734306-3	1996	PGE2-stimulated net water flux was also efficiently inhibited in the jejunum and ileum; PYY (ID50 about 10 pmol/kg.h) was 30 to 90 fold more potent than NPY.	Water	20-25	neuropeptide Y	Rattus norvegicus	153-156
8734306-5	1996	CONCLUSIONS: PYY and NPY display potent inhibitory effects of stimulated net water flux at the three studied levels of the small intestine, except in the PGE2-stimulated duodenum.	Water	77-82	neuropeptide Y	Rattus norvegicus	21-24
8683474-6	1996	The inhibitory effect of EHNA on vasopressin-induced water flow was dose dependent.	Water	53-58	arginine vasopressin	Homo sapiens	33-44
8609221-12	1996	Antibody localization of water channels showed strong expression of the mercurial-insensitive water channel (AQP-4) at the basolateral membrane of airway epithelial cells.	Water	25-30	aquaporin-4	Cavia porcellus	109-114
8609221-12	1996	Antibody localization of water channels showed strong expression of the mercurial-insensitive water channel (AQP-4) at the basolateral membrane of airway epithelial cells.	Water	94-99	aquaporin-4	Cavia porcellus	109-114
8824885-2	1996	In this study we investigate the effects of a perturbation in the ratio of Cu/Zn-superoxide dismutase activity (Sod1 dismutases .O2-to H2O2) to glutathione peroxidase activity (Gpx1 catalyses H2O2 conversion to H2O) on cell growth and development.	Water	135-138	superoxide dismutase 1	Homo sapiens	75-101
8824885-2	1996	In this study we investigate the effects of a perturbation in the ratio of Cu/Zn-superoxide dismutase activity (Sod1 dismutases .O2-to H2O2) to glutathione peroxidase activity (Gpx1 catalyses H2O2 conversion to H2O) on cell growth and development.	Water	135-138	superoxide dismutase 1	Homo sapiens	112-116
8906881-1	1996	We present here results on 260 pico seconds (ps) molecular dynamics (MD) simulation of substance P (SP) in hydrated bilayer of dimyristoyl phosphatidyl choline (DMPC) (39 molecules of DMPC with 776 water molecules).	Water	198-203	tachykinin precursor 1	Homo sapiens	87-98
8683474-9	1996	EHNA also inhibited the maintenance of the high rate of water flow established by prior exposure to vasopressin.	Water	56-61	arginine vasopressin	Homo sapiens	100-111
8683474-16	1996	The results are consistent with the hypothesis that dynein is involved in the microtubule-based delivery of water channel-containing vesicles to the apical membrane of the granular epithelial cells during both the onset and maintenance of the water permeability response to vasopressin.	Water	108-113	arginine vasopressin	Homo sapiens	274-285
8758444-6	1996	PAF receptor antagonist BN52021 could reduced water content and Even"s blue content of injured spinal cord tissue, also improve pathological change of spinal cord tissue after trauma.	Water	46-51	platelet activating factor receptor	Felis catus	0-12
8563764-2	1996	Several members of the MIP family transport water (aquaporins), glycerol and other small molecules in microbial, plant and animal cells.	Water	44-49	major intrinsic protein of lens fiber	Mus musculus	23-26
8867877-2	1996	Rats lapped drops of tap water from a force-sensing disk.	Water	25-30	nuclear RNA export factor 1	Rattus norvegicus	21-24
8596489-4	1996	Ingestion of 75 g glucose in 225 mL water (33.3% solution) increased plasma CCK bioactivity to a similar degree to that observed following Trelan G-75 (peak response, 4.5 +/- 0.4 pmol/L).	Water	36-41	cholecystokinin	Homo sapiens	76-79
8596489-6	1996	A smaller dose of glucose (50 b/150 mL water) increased plasma CCK concentration, although the peak level (3.0 +/- 0.5 pmol/L) was less than that observed following 75 g glucose.	Water	39-44	cholecystokinin	Homo sapiens	63-66
8628918-11	1996	Several cases of methemoglobinemia have been reported in infants in the United States using water containing nitrate at levels higher than the current maximum contaminant level (MCL) of 45 ppm (mg/liter) nitrate (NO3) or 10 ppm nitrate-nitrogen (nitrate-N), but none at or lower than the MCL.	Water	92-97	NBL1, DAN family BMP antagonist	Homo sapiens	213-216
8576117-9	1996	In contrast, AQP1 contributes &gt; 85% (Pf = 19 x 10(-3) cm/s) of the total osmotic water permeability pathway, and lipid permeation apparently comprises only approximately 10%.	Water	84-89	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
8576117-2	1996	The aquaporin-1 (AQP1) water transport protein contains a polymorphism corresponding to the Colton red blood cell antigens.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	4-15
8576117-2	1996	The aquaporin-1 (AQP1) water transport protein contains a polymorphism corresponding to the Colton red blood cell antigens.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	17-21
8576117-3	1996	To define the fraction of membrane water permeability mediated by AQP1, red cells were obtained from human kindreds with the rare Colton-null phenotype.	Water	35-40	aquaporin 1 (Colton blood group)	Homo sapiens	66-70
8955763-4	1996	The patients with a decreased response to water load had hyponatremia, hypervolemia, high cardiac index, low systemic vascular resistance, high plasma arginine vasopressin, high plasma renin activity, high plasma norepinephrine, low creatinine and p-aminohippurate clearances, low urine sodium and high urine osmolality.	Water	42-47	arginine vasopressin	Homo sapiens	160-171
8576117-8	1996	AQP1 contributes approximately 64% (Pd = 1.5 x 10(-3) cm/s) of the total diffusional water permeability pathway, and lipid permeation apparently comprises approximately 23%.	Water	85-90	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
8955763-4	1996	The patients with a decreased response to water load had hyponatremia, hypervolemia, high cardiac index, low systemic vascular resistance, high plasma arginine vasopressin, high plasma renin activity, high plasma norepinephrine, low creatinine and p-aminohippurate clearances, low urine sodium and high urine osmolality.	Water	42-47	renin	Homo sapiens	185-190
8955763-6	1996	The findings suggest that a decreased response to water load is due to peripheral vasodilatation which results in a decreased effective blood volume leading to the release of vasopressin and norepinephrine, increased renin activity and decreased renal hemodynamics.	Water	50-55	arginine vasopressin	Homo sapiens	175-186
8955763-6	1996	The findings suggest that a decreased response to water load is due to peripheral vasodilatation which results in a decreased effective blood volume leading to the release of vasopressin and norepinephrine, increased renin activity and decreased renal hemodynamics.	Water	50-55	renin	Homo sapiens	217-222
8770209-17	1996	This value indicates that apo-A1 binding to a fluid surface like egg yolk phosphatidylcholine or probably DPPC at 45 degrees C is hydrophobic and is consistent with hydrocarbon lipid or protein moities coming together and excluding water.	Water	232-237	apolipoprotein A1	Homo sapiens	26-32
8734452-2	1996	Renal V2 receptors mediate vasopressin-induced water reabsorption via induction of intracellular cAMP production in collecting duct cells.	Water	47-52	arginine vasopressin	Homo sapiens	27-38
9352681-6	1996	In the cases of cytochrome c and lysozyme, the water concentration was larger than that in the protein-free system in spite of the same AOT condition.	Water	47-52	cytochrome c, somatic	Homo sapiens	16-28
9352681-6	1996	In the cases of cytochrome c and lysozyme, the water concentration was larger than that in the protein-free system in spite of the same AOT condition.	Water	47-52	lysozyme	Homo sapiens	33-41
8993847-7	1996	Circulating AngII acts on AT1 receptors in the subfornical organ and organum vasculosum of the lamina terminalis (OVLT) to stimulate neurons that may have a role in initiating water drinking.	Water	176-181	angiotensinogen	Rattus norvegicus	12-17
8993849-2	1996	The effects of angiotensin II (AngII) on water and electrolyte transport are biphasic and dose-dependent, such that low concentrations (10(-12) to 10(-9) mol/L) stimulate reabsorption and high concentrations (10(-7) to 10(-6) mol/L) inhibit reabsorption.	Water	41-46	angiotensinogen	Homo sapiens	15-29
8993849-2	1996	The effects of angiotensin II (AngII) on water and electrolyte transport are biphasic and dose-dependent, such that low concentrations (10(-12) to 10(-9) mol/L) stimulate reabsorption and high concentrations (10(-7) to 10(-6) mol/L) inhibit reabsorption.	Water	41-46	angiotensinogen	Homo sapiens	31-36
8769841-0	1996	Nitric oxide inhibits ADH-stimulated osmotic water permeability in cortical collecting ducts.	Water	45-50	arginine vasopressin	Homo sapiens	22-25
8769841-2	1996	We hypothesized that NO inhibits antidiuretic hormone (ADH)-stimulated fluid reabsorption (J(r)) by the isolated rat cortical collecting duct (CCD) by decreasing water permeability (Pf) and sodium reabsorption (Jna).	Water	162-167	arginine vasopressin	Homo sapiens	55-58
8769841-16	1996	We concluded that 1) NO decreases ADH-stimulated water and sodium transport in the isolate CCD, and 2) water reabsorption is inhibited by a primary effect on Pf.	Water	49-54	arginine vasopressin	Homo sapiens	34-37
8772426-5	1996	The majority of molecular-level information about water-transporting mechanisms comes from studies on CHIP28, a 28-kDa glycoprotein that forms tetramers in membranes; each monomer contains six putative helical domains surrounding a central aqueous pathway and functions independently as a water-selective channel.	Water	50-55	aquaporin 1 (Colton blood group)	Homo sapiens	102-108
8772426-5	1996	The majority of molecular-level information about water-transporting mechanisms comes from studies on CHIP28, a 28-kDa glycoprotein that forms tetramers in membranes; each monomer contains six putative helical domains surrounding a central aqueous pathway and functions independently as a water-selective channel.	Water	289-294	aquaporin 1 (Colton blood group)	Homo sapiens	102-108
8815812-4	1996	Aquaporin-2 mediates vasopressin-dependent renal collecting duct water permeability; mutations or downregulation can cause nephrogenic diabetes insipidus.	Water	65-70	arginine vasopressin	Homo sapiens	21-32
8821517-4	1996	Only high concentrations of propolis extracts inhibited these enzymatic activities but especially the water-soluble derivatives showed stimulatory effect on the activity of commercially available human myeloperoxidase.	Water	102-107	myeloperoxidase	Homo sapiens	202-217
8907184-3	1996	In an air/water interface, the lipid displayed unique surface pressure-surface area isotherms with a limiting area of 105-190 Angstrom/molecule at 10-20 degrees C. The lipid was a substrate of phospholipase A2 (Naja mocambique), which afforded 1-palmitoyl-sn-glycero-3-phosphocholine and dotriacontanedioic acid as final products.	Water	10-15	phospholipase A2 group IB	Homo sapiens	193-209
8973842-0	1996	An immunotoxin, anti-VIP antibody-ricin A chain conjugate eliminates neurons in the hypothalamic suprachiasmatic nucleus selectively and abolishes the circadian rhythm of water intake.	Water	171-176	vasoactive intestinal peptide	Rattus norvegicus	21-24
8973842-8	1996	These findings suggest that SCN neurons bearing VIP receptors such as AVP neurons, but not VIP neurons, may be involved in the mechanism of the circadian rhythm of water intake.	Water	164-169	vasoactive intestinal peptide	Rattus norvegicus	48-51
8801137-4	1996	It is revealed that at each time point after E2 and PRL or metoclopramide treatment almost all the tested parameters were lower than those in control rats treated with E2 and distilled water.	Water	185-190	prolactin	Rattus norvegicus	52-55
8617893-8	1996	Previous work from this laboratory reported that osmotic water permeability in the skin of the toad Bufo arenarum was increased by angiotensin II, the effect being blocked by the peptide antagonist Leu8 angiotensin II.	Water	57-62	angiotensinogen	Homo sapiens	131-145
8617893-8	1996	Previous work from this laboratory reported that osmotic water permeability in the skin of the toad Bufo arenarum was increased by angiotensin II, the effect being blocked by the peptide antagonist Leu8 angiotensin II.	Water	57-62	angiotensinogen	Homo sapiens	203-217
8569695-6	1996	Expressed human microsomal epoxide hydrolase and HLM catalyzed the attack of water predominantly (approximately 96%) at C5 of the 5R,6S-oxide, whereas 5S,6R-oxide was attacked less selectivity (approximately 60% at C5).	Water	77-82	oxysterol binding protein 2	Homo sapiens	49-52
8818115-1	1996	Aquaporin-2 (AQP-2) has been shown to be a vasopressin-sensitive water channel in collecting duct (CD) cells of the kidney.	Water	65-70	arginine vasopressin	Rattus norvegicus	43-54
9019668-2	1996	The antidiuretic hormone arginine-vasopressin increases the water permeability of the renal collecting ducts and induces the reabsorption of 11 liters of water: the final urinary osmolality is 1200 mmol/kg for a urinary flow rate of 1 litre per 24 hours.	Water	60-65	arginine vasopressin	Homo sapiens	34-45
8987045-6	1996	AQP2 is expressed only in the principal cells of renal collecting duct where it is the predominant vasopressin (ADH, antidiuretic hormone) regulated water channel.	Water	149-154	arginine vasopressin	Homo sapiens	99-110
8987045-6	1996	AQP2 is expressed only in the principal cells of renal collecting duct where it is the predominant vasopressin (ADH, antidiuretic hormone) regulated water channel.	Water	149-154	arginine vasopressin	Homo sapiens	117-137
9019668-2	1996	The antidiuretic hormone arginine-vasopressin increases the water permeability of the renal collecting ducts and induces the reabsorption of 11 liters of water: the final urinary osmolality is 1200 mmol/kg for a urinary flow rate of 1 litre per 24 hours.	Water	154-159	arginine vasopressin	Homo sapiens	34-45
8728163-5	1996	Water channels, like aquaporin-CHIP, could be the morphological equivalent of these pores.	Water	0-5	aquaporin 1 (Colton blood group)	Homo sapiens	21-35
8855132-6	1996	These investigations suggest that the removal of large quantities of water and salt in each dialysis session may cause excessive secretion of renin.	Water	69-74	renin	Homo sapiens	142-147
8677192-1	1996	The role of the atrial natriuretic peptide (ANP) in Na and water metabolism is well recognized.	Water	59-64	natriuretic peptide A	Homo sapiens	16-42
8677192-1	1996	The role of the atrial natriuretic peptide (ANP) in Na and water metabolism is well recognized.	Water	59-64	natriuretic peptide A	Homo sapiens	44-47
8771197-10	1996	Simulation of CRP:(cAMP)2 in solution showed that a transition from the open to the closed state also occurs when water is explicitly included in the calculations.	Water	114-119	C-reactive protein	Homo sapiens	14-25
8768547-2	1996	The electron microscopic study of these cells by the freeze-fracture technique showed that the enhancement of water permeability by AVP-independent manner was related to the appearance of intramembranous particle aggregates in luminal membrane of granular cell, that are usually observed only under the action of AVP.	Water	110-115	arginine vasopressin	Homo sapiens	132-135
12237720-2	1996	The glycolipid-enzyme complex (SOD-2C(12)GE) is insoluble in water but soluble in organic solvents such as ethanol, acetone, glycerin and dioxane.	Water	61-66	superoxide dismutase 1	Homo sapiens	31-34
8731978-7	1996	AQP-CHIP assembles into homotetramers in the plasma membrane and each CHIP monomer appears to form a functional water pore.	Water	112-117	aquaporin 1 (Colton blood group)	Homo sapiens	0-8
18966460-0	1996	Study of chemical modifiers for direct determination of silver in sea water by ETA-AAS with deuterium background correction.	Water	70-75	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	83-86
8768547-2	1996	The electron microscopic study of these cells by the freeze-fracture technique showed that the enhancement of water permeability by AVP-independent manner was related to the appearance of intramembranous particle aggregates in luminal membrane of granular cell, that are usually observed only under the action of AVP.	Water	110-115	arginine vasopressin	Homo sapiens	313-316
8768547-3	1996	The immunocytochemical experiments with monoclonal antibodies against actin revealed the similarity in intracellular actin distribution under the action of AVP and AVP-independent increase of water permeability.	Water	192-197	arginine vasopressin	Homo sapiens	164-167
8686251-4	1996	TPA painting was followed by skin papilloma development in 20.9% of males and 36.6% females injected distilled water neonatally, tumors regressing in 88.4% of males and 85.4% of females by the end of the experiment.	Water	111-116	promotion susceptibility QTL 1	Mus musculus	0-3
8597423-3	1995	Macrophages are sensitive to stress in that cold-water stress causes increased cytokine production, either spontaneously (IL-1), or after induction with LPS (IL-6, TNF alpha).	Water	49-54	interleukin 6	Mus musculus	158-162
8762459-4	1996	After the onset of stroke, tap water and normal food was given instead of that containing NaCl.	Water	31-36	nuclear RNA export factor 1	Rattus norvegicus	27-30
8597423-3	1995	Macrophages are sensitive to stress in that cold-water stress causes increased cytokine production, either spontaneously (IL-1), or after induction with LPS (IL-6, TNF alpha).	Water	49-54	tumor necrosis factor	Mus musculus	164-173
8554523-7	1995	BK was also able to increase the release of [14C]ethanolamine, a water-soluble product of hydrolysis of phosphatidylethanolamine (PtdEtn), through PLD activation in young and old cells.	Water	65-70	kininogen 1	Homo sapiens	0-2
8750736-5	1995	In vivo, L-N6-(1-iminoethyl)-lysine (0.4-9 mM in the drinking water) suppressed inducible NO-synthase activity and caused a dramatic exacerbation of leishmaniasis, despite a counterregulatory increase of inducible NO-synthase protein in the tissue.	Water	62-67	nitric oxide synthase 2, inducible	Mus musculus	80-101
8927035-2	1995	Several compounds including those currently used as insulin-mimetic agents in animal and human studies are stable upon dissolution in distilled water but lack such stability in distilled water at pH 7.	Water	144-149	insulin	Homo sapiens	52-59
8599674-1	1995	For hydrated metmyoglobin, methemoglobin, and lysozyme powders, the freezable water fraction of between approximately 0.3-0.4 g water/g protein up to approximately 0.7-0.8 g water/g protein has been fully vitrified by cooling at rates up to approximately 1500 K min-1 and the influence of cooling rate characterized by x-ray diffractograms.	Water	78-83	lysozyme	Homo sapiens	46-54
8594881-2	1995	In the present studies, we examined the effects of nucleotides (ATP, UTP, and ADP; 10 microM each) on the arginine vasopressin (AVP, 0.1 nM)-stimulated osmotic water permeability (Pf) in in vitro perfused terminal inner medullary collecting ducts (IMCD) of rat.	Water	160-165	arginine vasopressin	Rattus norvegicus	115-126
8594930-2	1995	Intraperitoneal injection of 0.12 nmol/rat IL-1 beta decreased food and water intake and elevated body temperature.	Water	72-77	interleukin 1 beta	Rattus norvegicus	43-52
8599674-1	1995	For hydrated metmyoglobin, methemoglobin, and lysozyme powders, the freezable water fraction of between approximately 0.3-0.4 g water/g protein up to approximately 0.7-0.8 g water/g protein has been fully vitrified by cooling at rates up to approximately 1500 K min-1 and the influence of cooling rate characterized by x-ray diffractograms.	Water	78-83	CD59 molecule (CD59 blood group)	Homo sapiens	262-267
8599674-1	1995	For hydrated metmyoglobin, methemoglobin, and lysozyme powders, the freezable water fraction of between approximately 0.3-0.4 g water/g protein up to approximately 0.7-0.8 g water/g protein has been fully vitrified by cooling at rates up to approximately 1500 K min-1 and the influence of cooling rate characterized by x-ray diffractograms.	Water	128-133	lysozyme	Homo sapiens	46-54
8599674-1	1995	For hydrated metmyoglobin, methemoglobin, and lysozyme powders, the freezable water fraction of between approximately 0.3-0.4 g water/g protein up to approximately 0.7-0.8 g water/g protein has been fully vitrified by cooling at rates up to approximately 1500 K min-1 and the influence of cooling rate characterized by x-ray diffractograms.	Water	128-133	lysozyme	Homo sapiens	46-54
8787777-3	1995	An acidic polysaccharide (TAP) was isolated from a hot-water extract of the fruiting bodies of Tremella aurantia.	Water	55-60	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	26-29
8599674-3	1995	Measurements by differential scanning calorimetry have shown that this vitreous but freezable water fraction undergoes, on reheating at a rate of 30 K min-1, a glass--&gt;liquid transition with an onset temperature of between approximately 164 and approximately 174 K, with a width of between approximately 9 and approximately 16 degrees and an increase in heat capacity of between approximately 20 and approximately 40 J K-1 (mol of freezable water)-1 but that the glass transition disappears upon crystallization of the freezable water.	Water	94-99	CD59 molecule (CD59 blood group)	Homo sapiens	151-156
8846844-2	1995	The natriuretic peptides, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are vasodilators with variable effects on electrolyte and water transport at sites such as the nephron.	Water	187-192	natriuretic peptide B	Rattus norvegicus	60-85
8846844-2	1995	The natriuretic peptides, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are vasodilators with variable effects on electrolyte and water transport at sites such as the nephron.	Water	187-192	natriuretic peptide B	Rattus norvegicus	87-90
7490395-11	1995	Water load testing revealed abnormal water handling consistent with the syndrome of inappropriate antidiuretic hormone (ADH) secretion in 18 of 23 patients who had a history of hyponatremia.	Water	0-5	arginine vasopressin	Homo sapiens	120-123
8543757-7	1995	At 900 mOsm/kg H2O, which has been suggested as the osmolarity of the fluid lining the airways during exercise, we observed a significant increase (Wilcoxon W test) in the release of 15-hydroxyeicosatetraenoic acid (p &lt; 0.008), leukotriene B4 (p &lt; 0.008), and prostaglandin2 (p &lt; 0.008), but no significant increase in the release of fibronectin was seen.	Water	15-18	fibronectin 1	Homo sapiens	343-354
7490619-6	1995	Concentrations of human thrombin as low as 1 U/microliter resulted in a significant increase in brain water content.	Water	102-107	coagulation factor II, thrombin	Homo sapiens	24-32
8847275-10	1995	Antidiuretic hormone concentrations (ADH) were significantly reduced from prehyperhydration levels during both hyperhydration trials but tended (P = 0.07) to rise during GI compared with WI at the very time urine flow and free water clearance differences were also evident.	Water	227-232	arginine vasopressin	Homo sapiens	0-20
8825722-0	1995	A one nanosecond molecular dynamics simulation of the glucocorticoid receptor protein in complex with a glucocorticoid response element DNA sequence in a 10 Angstrom water layer.	Water	166-171	nuclear receptor subfamily 3 group C member 1	Homo sapiens	54-77
8825722-1	1995	We investigated protein/DNA interactions, using molecular dynamics simulations computed for one nanosecond, between a 10 Angstom water layer model of the glucocorticoid receptor (GR) DNA binding domain (DBD) amino acids and DNA of a glucocorticoid receptor response element (GRE) consisting of 29 nucleotide base pairs.	Water	129-134	nuclear receptor subfamily 3 group C member 1	Homo sapiens	154-177
8653552-2	1995	IL-1 beta decreased food and water intake and elevated body temperature.	Water	29-34	interleukin 1 beta	Rattus norvegicus	0-9
8554732-1	1995	Plasma active renin consists of multiple glycoforms, which are differentially stored and secreted by the kidney, have varying plasma half-lives, and appear to have differing effects on renal sodium and water metabolism.	Water	202-207	renin	Homo sapiens	14-19
8903836-9	1995	Total body water (l) increased significantly during GH administration (placebo, 50.8 +/- 2.6; 3 IU m-2, 52.6 +/- 2.3; 6 IU m-2, 53.9 +/- 1.8, p&lt;0.05).	Water	11-16	growth hormone 1	Homo sapiens	52-54
8903836-12	1995	In conclusion, GH administration induces an elevation in total body water which may involve a stimulation of plasma renin and an increased ECV without any changes in PV or diurnal blood pressure.	Water	68-73	growth hormone 1	Homo sapiens	15-17
8903836-12	1995	In conclusion, GH administration induces an elevation in total body water which may involve a stimulation of plasma renin and an increased ECV without any changes in PV or diurnal blood pressure.	Water	68-73	renin	Homo sapiens	116-121
7488137-2	1995	Using this and the H2O2-Cyt-c system, we proved that monoepoxide production from linoleic acid was due to hydroxy radical formation by the reaction of Cyt-c with H2O2 and not to the formation of other active oxygen species.	Water	106-121	cytochrome c, somatic	Homo sapiens	24-29
7488137-2	1995	Using this and the H2O2-Cyt-c system, we proved that monoepoxide production from linoleic acid was due to hydroxy radical formation by the reaction of Cyt-c with H2O2 and not to the formation of other active oxygen species.	Water	106-121	cytochrome c, somatic	Homo sapiens	151-156
7479859-5	1995	Eight days after pituitary stalk transection the NL AVP mRNA diminished in animals given water to drink, whereas in those given 2% saline for 18 h followed by 6 h of water, a treatment repeated on 6 successive days beginning 2 days after surgery, the 0.62-kb AVP mRNA was present.	Water	89-94	arginine vasopressin	Rattus norvegicus	52-55
7578036-11	1995	Some differences in sequence, however, create a larger binding site that contains six more water molecules than in the aldose reductase ternary complex structure.	Water	91-96	aldo-keto reductase family 1 member B	Homo sapiens	119-135
15299771-4	1995	In addition to this hydrated DNA helix, the monoclinic unit cell (space group P2(1)) accommodates about 20 sodium ions and 12 water molecules in the vicinity of phosphate groups.	Water	126-131	cyclin dependent kinase inhibitor 1A	Homo sapiens	78-83
8808225-10	1995	RESULTS: The water and solute excretion in DI-1 and DI-2 were similar.	Water	13-18	arginine vasopressin receptor 2	Homo sapiens	43-47
8537610-2	1995	The in vitro proliferative response of bone marrow (BM) cells to interleukin-3 (IL-3) was significantly increased when mice were provided with 0.1% MMI in water (w/v) ad librium for 4 to 6 weeks.	Water	155-160	interleukin 3	Mus musculus	65-78
7503290-4	1995	ANG II-induced water intake and pressor responses.	Water	15-20	angiotensinogen	Rattus norvegicus	0-6
7503290-9	1995	These results are consistent with Other observations indicating that the LPBN is associated with inhibitory mechanisms controlling water intake induced by ANG II treatment and suggest that serotonergic pathways may be involved in this effect.	Water	131-136	angiotensinogen	Rattus norvegicus	155-161
8608666-11	1995	We conclude that simultaneous measurements of plasma BNP and ANP further discriminate salt-water and hemodynamic abnormalities in dialysis patients.	Water	91-96	natriuretic peptide A	Homo sapiens	61-64
8537610-2	1995	The in vitro proliferative response of bone marrow (BM) cells to interleukin-3 (IL-3) was significantly increased when mice were provided with 0.1% MMI in water (w/v) ad librium for 4 to 6 weeks.	Water	155-160	interleukin 3	Mus musculus	80-84
9223015-7	1995	Induced lipid interaction via N-terminal lipo-derivatization of gastrin and CCK allowed to translocate quantitatively the two hormones into phospholipid bilayers and to examine the effect of extravesicular Ca2+ on the conformation of the peptide headgroups and on their display at the water/lipid interphase.	Water	285-290	cholecystokinin	Homo sapiens	76-79
8606364-8	1995	Correction of PHA for those temperature effects considered to be independent of lipid chain order (i.e., enthalpy of transfer from water to decane and activation energy for diffusion in bulk hydrocarbon) yielded an improved correlation (kappa = -11.7 +/- 0.5 (r = 0.96)).	Water	131-136	lamin B receptor	Homo sapiens	14-17
8637618-6	1995	Angiotensin II stimulated intakes of both water and NaCl.	Water	42-47	angiotensinogen	Rattus norvegicus	0-14
7485521-2	1995	CRP was shown to detract from the ability of surfactant to rapidly adsorb to the air-water interface at a molar ratio of 0.03:1 (protein:phospholipid) (weight ratio, 0.5:1).	Water	85-90	C-reactive protein	Homo sapiens	0-3
7589481-0	1995	Functional expression of the human CHIP28 water channel in a yeast secretory mutant.	Water	42-47	aquaporin 1 (Colton blood group)	Homo sapiens	35-41
7589481-1	1995	The temperature-sensitive Saccharomyces cerevisiae mutant strain NY17, deficient in the secretory pathway (sec6-4 mutation), is used for the heterologous expression of the human CHIP28 water channel.	Water	185-190	aquaporin 1 (Colton blood group)	Homo sapiens	178-184
7589481-3	1995	Immunodetection and water transport studies, directly made on the vesicles, showed that CHIP28 is highly expressed and active in the yeast membranes.	Water	20-25	aquaporin 1 (Colton blood group)	Homo sapiens	88-94
16296241-3	1995	Atrial natriuretic peptide (ANP), realized from the heart during hypervolaemia, increases glomerular filtration rate, renal sodium and water elimination in both experimental animals and healthy men.	Water	135-140	natriuretic peptide A	Homo sapiens	0-26
16296241-3	1995	Atrial natriuretic peptide (ANP), realized from the heart during hypervolaemia, increases glomerular filtration rate, renal sodium and water elimination in both experimental animals and healthy men.	Water	135-140	natriuretic peptide A	Homo sapiens	28-31
8556339-3	1995	Centrally injected ANG II (50 ng/1 microliters) induced water intake (10.2 +/- 0.8 ml/h) and pressor responses (22 +/- 1 mmHg).	Water	56-61	angiotensinogen	Rattus norvegicus	19-25
8556339-8	1995	ANG II are consistent with electrolytic and neurotoxic lesion studies and suggest that the LPBN is associated with inhibitory mechanisms controlling water intake induced by ANG II.	Water	149-154	angiotensinogen	Rattus norvegicus	0-6
8556339-8	1995	ANG II are consistent with electrolytic and neurotoxic lesion studies and suggest that the LPBN is associated with inhibitory mechanisms controlling water intake induced by ANG II.	Water	149-154	angiotensinogen	Rattus norvegicus	173-179
7485521-6	1995	These data suggest that the potent inhibition of surfactant adsorption by CRP is primarily a result of a specific interaction between CRP and the phosphocholine headgroup of surfactant lipids in the subphase and that it can be reversed by the water-soluble CRP ligand, phosphocholine.	Water	243-248	C-reactive protein	Homo sapiens	74-77
7485521-6	1995	These data suggest that the potent inhibition of surfactant adsorption by CRP is primarily a result of a specific interaction between CRP and the phosphocholine headgroup of surfactant lipids in the subphase and that it can be reversed by the water-soluble CRP ligand, phosphocholine.	Water	243-248	C-reactive protein	Homo sapiens	134-137
7485521-6	1995	These data suggest that the potent inhibition of surfactant adsorption by CRP is primarily a result of a specific interaction between CRP and the phosphocholine headgroup of surfactant lipids in the subphase and that it can be reversed by the water-soluble CRP ligand, phosphocholine.	Water	243-248	C-reactive protein	Homo sapiens	134-137
7578943-1	1995	The conformation of two highly potent parathyroid hormone (PTH) antagonists was investigated in water/2,2,2-trifluoroethanol mixtures.	Water	96-101	parathyroid hormone	Homo sapiens	38-57
7496476-7	1995	After water loading, patient remained euvolemic, with a negative free water clearance and an increased plasma ADH level with concomitant hyposmolality.	Water	6-11	arginine vasopressin	Homo sapiens	110-113
7578943-1	1995	The conformation of two highly potent parathyroid hormone (PTH) antagonists was investigated in water/2,2,2-trifluoroethanol mixtures.	Water	96-101	parathyroid hormone	Homo sapiens	59-62
7669916-9	1995	Conformers of ET-1 favored by the electrostatic solvation energy in water include conformers with helical secondary structure in the region of residues 9-15.	Water	68-73	endothelin 1	Homo sapiens	14-18
8534822-3	1995	The dielectric constant for water in this system is 41, which is much smaller than 71 for pure SPC/E water, because of the strong restriction imposed on the motion of water molecules by the DNA and the ions.	Water	28-33	proline rich protein gene cluster	Homo sapiens	95-98
8534822-3	1995	The dielectric constant for water in this system is 41, which is much smaller than 71 for pure SPC/E water, because of the strong restriction imposed on the motion of water molecules by the DNA and the ions.	Water	101-106	proline rich protein gene cluster	Homo sapiens	95-98
8534822-3	1995	The dielectric constant for water in this system is 41, which is much smaller than 71 for pure SPC/E water, because of the strong restriction imposed on the motion of water molecules by the DNA and the ions.	Water	101-106	proline rich protein gene cluster	Homo sapiens	95-98
8528653-3	1995	The large estimated partition coefficient of 1,2,3,4-TCDD in 10% 2-propanol/water (&gt; 1000) indicates that on the C18 stationary phase, both the saturated hydrocarbon chains and the absorbed 2-propanol may act as proton donors and accelerate the photolysis.	Water	76-81	Bardet-Biedl syndrome 9	Homo sapiens	116-119
7560075-2	1995	Body water balance is controlled by vasopressin, which regulates Aquaporin-2 (AQP2) water channels in kidney collecting duct cells by vesicular trafficking between intracellular vesicles and the plasma membrane.	Water	5-10	arginine vasopressin	Homo sapiens	36-47
7560075-14	1995	In conclusion, VAMP2, a component of the neuronal SNARE complex, is expressed in vesicles carrying AQP2, suggesting a role in vasopressin-regulated vesicle trafficking of AQP2 water channels.	Water	176-181	vesicle associated membrane protein 2	Homo sapiens	15-20
7560075-14	1995	In conclusion, VAMP2, a component of the neuronal SNARE complex, is expressed in vesicles carrying AQP2, suggesting a role in vasopressin-regulated vesicle trafficking of AQP2 water channels.	Water	176-181	arginine vasopressin	Homo sapiens	126-137
8569144-0	1995	Role of atrial natriuretic peptide in disturbed water and electrolyte metabolism of guinea pigs infected with Pichinde virus.	Water	48-53	natriuretic peptide A	Homo sapiens	8-34
8569144-6	1995	To determine a possible relationship between atrial natriuretic peptide (ANP) and urinary Na+ and water excretion over intake, we measured plasma ANP concentrations.	Water	98-103	natriuretic peptide A	Homo sapiens	45-71
8569144-6	1995	To determine a possible relationship between atrial natriuretic peptide (ANP) and urinary Na+ and water excretion over intake, we measured plasma ANP concentrations.	Water	98-103	natriuretic peptide A	Homo sapiens	73-76
8569144-10	1995	Among other pathophysiologic mechanisms, the increased plasma ANP concentration may have played a role in the development of disturbed water and electrolytes metabolism during Pichinde virus infection.	Water	135-140	natriuretic peptide A	Homo sapiens	62-65
7547939-5	1995	The catalyzed hydrolysis of substrate, corrected for the effect of hydrophobic partitioning, was demonstrated to be sixth order in water for gelatinase A and third order in water for stromelysin 1.	Water	131-136	matrix metallopeptidase 3	Homo sapiens	183-196
7547939-5	1995	The catalyzed hydrolysis of substrate, corrected for the effect of hydrophobic partitioning, was demonstrated to be sixth order in water for gelatinase A and third order in water for stromelysin 1.	Water	173-178	matrix metallopeptidase 3	Homo sapiens	183-196
7573395-1	1995	Aquaporin-2 (AQP2) is the predominant vasopressin-regulated water channel of the renal collecting duct.	Water	60-65	arginine vasopressin	Rattus norvegicus	38-49
7573395-6	1995	This increase averaged 2.0-fold in untreated rats and 2.9-fold in rats water loaded for 12 h. Water loading, presumably by suppressing circulating vasopressin levels, decreased the fraction of AQP2 associated with the plasma membrane by 55%, suggesting retrieval of AQP2 from the plasma membrane.	Water	71-76	arginine vasopressin	Rattus norvegicus	147-158
7573395-6	1995	This increase averaged 2.0-fold in untreated rats and 2.9-fold in rats water loaded for 12 h. Water loading, presumably by suppressing circulating vasopressin levels, decreased the fraction of AQP2 associated with the plasma membrane by 55%, suggesting retrieval of AQP2 from the plasma membrane.	Water	94-99	arginine vasopressin	Rattus norvegicus	147-158
8540707-8	1995	In tissues challenged with 0.5 to 1.0 mIU of ADH per ml, 1.0 to 10 mM foscarnet increased water flow but did not alter urea flux.	Water	90-95	arginine vasopressin	Homo sapiens	45-48
8540707-11	1995	These results indicate that foscarnet stimulates water flow induced by 0.5 to 1.0 mIU of ADH per ml at a site proximal to that of the generation of cyclic AMP and inhibits urea flux induced by a maximal dose of ADH at a separate site.	Water	49-54	arginine vasopressin	Homo sapiens	89-92
8574327-0	1995	Induction and intracellular localization of a 72-kDa heat shock protein in rat gastric mucosa after water-immersion stress.	Water	100-105	selenoprotein K	Rattus norvegicus	53-71
8574327-1	1995	We investigated the expression and changes in the intracellular localization of a 72-kDa heat shock protein (HSP72) in rat gastric pyloric and fundic mucosa before and after water-immersion stress.	Water	174-179	selenoprotein K	Rattus norvegicus	89-107
8569068-5	1995	The results indicate that CHIP28 transports water selectively, that CHIP28 monomers are assembled in membranes as tetramers, but that individual monomers function independently.	Water	44-49	aquaporin 1 (Colton blood group)	Homo sapiens	26-32
8569068-5	1995	The results indicate that CHIP28 transports water selectively, that CHIP28 monomers are assembled in membranes as tetramers, but that individual monomers function independently.	Water	44-49	aquaporin 1 (Colton blood group)	Homo sapiens	68-74
8569068-7	1995	Based on these data and recent electron crystallography results, a model for water transport is proposed in which water moves through narrow pores located within individual CHIP28 monomers.	Water	77-82	aquaporin 1 (Colton blood group)	Homo sapiens	173-179
8569068-7	1995	Based on these data and recent electron crystallography results, a model for water transport is proposed in which water moves through narrow pores located within individual CHIP28 monomers.	Water	114-119	aquaporin 1 (Colton blood group)	Homo sapiens	173-179
8569070-0	1995	Molecular mechanisms for the regulation of water transport in amphibian epithelia by antidiuretic hormone.	Water	43-48	arginine vasopressin	Homo sapiens	85-105
9979776-0	1995	Water adsorption on a BaF2(111) surface in air observed with force microscopy.	Water	0-5	BANF family member 2	Homo sapiens	22-26
7573412-5	1995	Cellubrevin, therefore, is in a position to mediate one or more steps in arginine vasopressin-induced water channel cycling.	Water	102-107	arginine vasopressin	Rattus norvegicus	82-93
8845824-5	1995	The sham-operated rats (sham group) were fed a normal diet and tap water.	Water	67-72	nuclear RNA export factor 1	Rattus norvegicus	63-66
8593329-0	1995	[Effect of muscarinic agonists and antagonists on vasopressin-stimulated water transport in the amphibian bladder].	Water	73-78	arginine vasopressin	Homo sapiens	50-61
8580890-0	1995	Progesterone administration to ovariectomized rats reduces water and salt intake induced by central administration of angiotensin II.	Water	59-64	angiotensinogen	Rattus norvegicus	118-132
8580890-2	1995	ANG II injected in intact rats (4, 6, 12, 25, and 50 ng, icv, in 0.5 microliter saline) induced an increase in water intake (4.3 +/- 0.6, 5.4 +/- 0.7, 7.8 +/- 0.8, 10.4 +/- 1.2, 11.2 +/- 1.4 ml/120 min, respectively) (N = 43).	Water	111-116	angiotensinogen	Rattus norvegicus	0-6
8580890-4	1995	When administered to ovariectomized rats ANG II induced comparable amounts of water intake (4.0 +/- 0.5, 4.8 +/- 0.6, 6.9 +/- 0.7, 9.6 +/- 0.8, and 10.9 +/- 1.2 ml/120 min, respectively) (N = 43) but there was a significant decrease of 3% NaCl solution ingestion (0.3 +/- 0.1, 0.4 +/- 0.1, 0.8 +/- 0.2, 0.7 +/- 0.2, and 0.6 +/- 0.2 ml/120 min, respectively) (N = 44).	Water	78-83	angiotensinogen	Rattus norvegicus	41-47
7498247-0	1995	Direct assessment of extracellular water volume by the bromide-dilution method in growth hormone-deficient adults.	Water	35-40	growth hormone 1	Homo sapiens	82-96
8564440-3	1995	It has been shown that aquaporin-collecting duct is a vasopressin-responsive water channel, and that it is regulated by a membrane shuttle mechanism.	Water	77-82	arginine vasopressin	Homo sapiens	54-65
8542675-3	1995	The acute effect of increasing plasma concentrations of ethanol was evaluated in a water diuretic anaesthetized rat model which inhibits endogenous arginine vasopressin (AVP) release.	Water	83-88	arginine vasopressin	Rattus norvegicus	157-168
8542675-3	1995	The acute effect of increasing plasma concentrations of ethanol was evaluated in a water diuretic anaesthetized rat model which inhibits endogenous arginine vasopressin (AVP) release.	Water	83-88	arginine vasopressin	Rattus norvegicus	170-173
8567519-10	1995	Aldosterone response to renin was maintained among the SLH group but was attenuated in the HA groups, possibly owing to a protective mechanism against salt and water retention.	Water	160-165	renin	Homo sapiens	24-29
7584123-2	1995	Administration of plasmid DNA encoding the chloramphenicol acetyltransferase gene (CAT) in sterile water lead to CAT transgene expression that peaked between 1 and 3 days and was detected up to 28 days after DNA administration.	Water	99-104	catalase	Mus musculus	83-86
7584123-2	1995	Administration of plasmid DNA encoding the chloramphenicol acetyltransferase gene (CAT) in sterile water lead to CAT transgene expression that peaked between 1 and 3 days and was detected up to 28 days after DNA administration.	Water	99-104	catalase	Mus musculus	113-116
8963034-2	1995	Rats drank a solution of nicotine 25 micrograms/mL tap water for periods of 10, 30 or 45 days.	Water	55-60	nuclear RNA export factor 1	Rattus norvegicus	51-54
8963034-3	1995	Pentagastrin increased the gastric secretory volume and acid output in pylorus-ligated control animals that drank tap water.	Water	118-123	nuclear RNA export factor 1	Rattus norvegicus	114-117
7562492-3	1995	Preliminary studies indicated that SB 203220 (600 ppm in the diet) and captopril (250 mg/l in drinking water) significantly attenuated the pressor activity of exogenous angiotensin II and angiotensin I, respectively.	Water	103-108	angiotensinogen	Rattus norvegicus	169-183
7552739-0	1995	The CHIP28 water channel visualized in ice by electron crystallography.	Water	11-16	aquaporin 1 (Colton blood group)	Homo sapiens	4-10
8558359-4	1995	The sensitivity of the Tb(III) decay rate to deuterated solvent was also measured and is consistent with a single water molecule bound to the metal in both the calmodulin and calmodulin-M13 complex.	Water	114-119	calmodulin 1	Homo sapiens	160-170
8558359-4	1995	The sensitivity of the Tb(III) decay rate to deuterated solvent was also measured and is consistent with a single water molecule bound to the metal in both the calmodulin and calmodulin-M13 complex.	Water	114-119	calmodulin 1	Homo sapiens	175-185
7552739-1	1995	Electron crystallography of frozen-hydrated two-dimensional crystals of deglycosylated human erythrocyte CHIP28 reveals an aqueous vestibule in each monomer leading to the water-selective channel that is enclosed by multiple transmembrane alpha-helices.	Water	172-177	aquaporin 1 (Colton blood group)	Homo sapiens	105-111
7552740-1	1995	Using cryo-electron microscopy we have determined a projection map of the structure of the water selective pore aquaporin-1.	Water	91-96	aquaporin 1 (Colton blood group)	Homo sapiens	112-123
7671346-4	1995	Metabolism of BaP to water-soluble metabolites by HepG2 cells in culture was 50% lower in fluorescein isothiocyanate (FITC)-insulin-CYP1A1-antibody-conjugate-treated cells than in control cells.	Water	21-26	insulin	Homo sapiens	124-131
7545008-1	1995	Two sandwich enzyme linked immunosorbent assays (ELISA) were developed for evaluating the surface excess at the lipid/water interface of the human gastric lipase (HGL) and two anti-HGL monoclonal antibodies (mAbs).	Water	118-123	lipase F, gastric type	Homo sapiens	147-161
7545008-9	1995	At a given lipase concentration in the water subphase, the interfacial binding of HGL to the nonhydrolyzable egg yolk phosphatidylcholine (egg PC) monolayers was found to be 10 times lower than that in the case of dicaprin monolayers.	Water	39-44	lipase F, gastric type	Homo sapiens	82-85
7646505-1	1995	The conformational analysis of the CCK-B binding peptide cyclo (Asp-Trp-Met-Asp-Phe) has been carried out in DMSO-d6 and in a mixture of H2O/DMSO-d6 by NMR spectroscopy and by restrained molecular dynamics methods.	Water	137-140	cholecystokinin B receptor	Homo sapiens	35-40
7646471-0	1995	Thrombin-thrombomodulin interaction: energetics and potential role of water as an allosteric effector.	Water	70-75	coagulation factor II, thrombin	Homo sapiens	0-8
7615197-2	1995	The aim of this study was to investigate the mechanism of action of IL-1 beta on colonic net water flux and the role of tachykinins and nitric oxide.	Water	93-98	interleukin 1 beta	Rattus norvegicus	68-77
7544530-1	1995	In the toad urinary bladder, antidiuretic hormone (ADH)-mediated changes in water permeability depend on exocytic insertion and endocytic retrieval of water channels into and from the apical membrane, respectively.	Water	76-81	arginine vasopressin	Homo sapiens	29-49
7544530-1	1995	In the toad urinary bladder, antidiuretic hormone (ADH)-mediated changes in water permeability depend on exocytic insertion and endocytic retrieval of water channels into and from the apical membrane, respectively.	Water	76-81	arginine vasopressin	Homo sapiens	51-54
7544530-6	1995	Therefore, we suggest that the ADH-dependent cycling of water channels could be controlled by one or more G proteins associated with the apical membrane and/or the water channel-carrying vesicles.	Water	56-61	arginine vasopressin	Homo sapiens	31-34
7628384-8	1995	Upon treatment of the animals with the mild goitrogenic agent n-propylthiouracil (200 mg/liter drinking water), a fast reduction in the transcript levels of the TRH-degrading ectoenzyme became evident.	Water	104-109	thyrotropin-releasing hormone degrading enzyme	Rattus norvegicus	161-185
7675830-5	1995	Water consumption was significantly enhanced by both peptides at both sites and could be attenuated by prior treatment with the ANG II antagonist Sar1Thr8-ANG II.	Water	0-5	angiotensinogen	Rattus norvegicus	128-134
8655189-6	1995	A linear relationship was obtained between log K (the partitioning of the beta-blocker in DMPC and also in octanol/water) and the potencies of these beta1-antagonists.	Water	115-120	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	149-154
7675830-5	1995	Water consumption was significantly enhanced by both peptides at both sites and could be attenuated by prior treatment with the ANG II antagonist Sar1Thr8-ANG II.	Water	0-5	angiotensinogen	Rattus norvegicus	155-161
7481879-5	1995	of angiotensin II at a rate of 0.2 nmol/h for 2 days by using a miniosmotic pump resulted in a significant increase in daily water intake.	Water	125-130	angiotensinogen	Rattus norvegicus	3-17
7481879-12	1995	It is therefore suggested that the administration of ANG II enhances AVP gene transcription in the hypothalamus, especially when water intake is limited.	Water	129-134	arginine vasopressin	Rattus norvegicus	69-72
7608188-4	1995	SP-C enhances the adsorption of phospholipids into an air-water interface.	Water	58-63	surfactant protein C	Homo sapiens	0-4
7570434-8	1995	Vasopressin levels were abnormally raised for the osmolality in patients in group C and in those with autonomic dysfunction throughout the water load and at 240 minutes after the salt load.	Water	139-144	arginine vasopressin	Homo sapiens	0-11
7583314-1	1995	In the rat, the cellular dehydration induced by water deprivation rapidly increases CRH mRNA in magnocellular neurosecretory neurons, but gradually reduces mRNA levels in hypothalamic paraventricular parvicellular neurosecretory neurons.	Water	48-53	corticotropin releasing hormone	Rattus norvegicus	84-87
7583314-2	1995	Using in situ hybridization we investigated a possible role for corticosterone as a mediator of the effects of water deprivation on the levels of CRH mRNA in the paraventricular and supraoptic nuclei.	Water	111-116	corticotropin releasing hormone	Rattus norvegicus	146-149
7583314-3	1995	Following adrenalectomy and water deprivation, the reduction of CRH mRNA in the medial parvicellular part of the paraventricular nucleus was inhibited.	Water	28-33	corticotropin releasing hormone	Rattus norvegicus	64-67
7583314-6	1995	We conclude that an intact adrenal gland is required for the decreased levels of CRH mRNA seen during water deprivation in parvicellular paraventricular neurosecretory neurons, but not magnocellular neurosecretory neurons.	Water	102-107	corticotropin releasing hormone	Rattus norvegicus	81-84
7611241-10	1995	The results of the present analysis show that acute water loading per se may enhance renal sodium excretion and hence modify the level of activity of the renin-angiotensin system expected from a given sodium diet.	Water	52-57	renin	Homo sapiens	154-159
7631792-7	1995	Pretreatment of the animals with both atropine and the VIP antagonist completely abolished ileal and jejunal water secretion stimulated by cerebral TRH.	Water	109-114	vasoactive intestinal peptide	Rattus norvegicus	55-58
7543252-9	1995	Nevertheless, immunofluorescence studies of inner medullary tissue from Brattleboro rats revealed a marked redistribution of the aquaporin-CD water channels to a predominantly apical and subapical localization in IMCD cells in response to water restriction, similar to the redistribution seen in response to vasopressin.	Water	142-147	arginine vasopressin	Rattus norvegicus	308-319
7543252-9	1995	Nevertheless, immunofluorescence studies of inner medullary tissue from Brattleboro rats revealed a marked redistribution of the aquaporin-CD water channels to a predominantly apical and subapical localization in IMCD cells in response to water restriction, similar to the redistribution seen in response to vasopressin.	Water	239-244	arginine vasopressin	Rattus norvegicus	308-319
7543252-11	1995	We conclude that oxytocin can function physiologically as an antidiuretic hormone, mimicking the short-term action of vasopressin on water permeability, albeit with somewhat lower potency.	Water	133-138	arginine vasopressin	Rattus norvegicus	118-129
7575330-1	1995	The advances in our understanding of the pathophysiology of defects in the antidiuretic hormone, the V2 receptor and the water channel, owing to mutations in the prepro-AVP-NPII, AVPR2 and AQP2 genes respectively, is providing insight into inherited diabetes insipidus as well as the more numerous sporadic cases.	Water	121-126	arginine vasopressin	Homo sapiens	169-177
7575330-1	1995	The advances in our understanding of the pathophysiology of defects in the antidiuretic hormone, the V2 receptor and the water channel, owing to mutations in the prepro-AVP-NPII, AVPR2 and AQP2 genes respectively, is providing insight into inherited diabetes insipidus as well as the more numerous sporadic cases.	Water	121-126	arginine vasopressin receptor 2	Homo sapiens	179-184
7575330-2	1995	Further structure-function analyses of these mutated genes will increase our understanding of normal vasopressin-regulated water transport across the kidney epithelium at the molecular level.	Water	123-128	arginine vasopressin	Homo sapiens	101-112
7671564-7	1995	Infusion of arginine vasopressin alone (0.5 m-units/min) caused a marked reduction in both fractional clearance of free water (10.7% +/- 1.2% to -1.2% +/- 0.2%, P &lt; 0.001) and flow rate factored for glomerular filtration rate (14.0 +/- 1.5 to 0.8 +/- 0.2%; P &lt; 0.001) while the fractional excretion of lithium showed only a small non-significant decrease (25.3% +/- 2.0% to 23.3% +/- 2.2%).	Water	120-125	arginine vasopressin	Homo sapiens	21-32
8751046-1	1995	Prazosin (PRZ) in conventional tablet form (P-CT) has the disadvantages of a relatively short terminal half-life, a slight solubility in water and the well-recognized adverse effect of symptomatic orthostatic hypotension.	Water	137-142	calcitonin related polypeptide alpha	Homo sapiens	44-48
7580750-0	1995	[The role of protein kinase C and muscarinic cholinoreceptors in vasopressin-stimulated water transport].	Water	88-93	arginine vasopressin	Homo sapiens	65-76
7580750-1	1995	The role of protein kinase C (PKC) in the control of vasopressin-stimulated water transport in the frog urinary bladder and its modulation by M2-agonist oxotremorine has been studied.	Water	76-81	arginine vasopressin	Homo sapiens	53-64
7580750-2	1995	Using the PKC inhibitor, staurosporine we showed that PKC in the region pf the basal membrane suppressed vasopressin-stimulated water transport, whereas PKC in the apical region potentiated this transport.	Water	128-133	arginine vasopressin	Homo sapiens	105-116
24283639-5	1995	It can be concluded that AVP plays important roles in the development of antidiuresis after water loading and in the disturbance of the brain water and electrolyte balance following experimental SAH.	Water	92-97	arginine vasopressin	Rattus norvegicus	25-28
24283639-5	1995	It can be concluded that AVP plays important roles in the development of antidiuresis after water loading and in the disturbance of the brain water and electrolyte balance following experimental SAH.	Water	142-147	arginine vasopressin	Rattus norvegicus	25-28
7558597-3	1995	A significant contribution from a slow rotational component supports either the persistence, on the nano-second timescale at least, of a non-flexible alpha-helical structure for the C-terminal tail residues of endothelin-1 in water as solvent, as seen in the X-ray crystallographic structure, or the interaction of the C-terminal tail residues 16-21 with the constrained disulfide-bridged core residues 1-15.	Water	226-231	endothelin 1	Homo sapiens	210-222
7790382-6	1995	The suppression of PLC-gamma 1 tyrosine phosphorylation was accompanied by a decreased production of water soluble inositol phosphates.	Water	101-106	phospholipase C gamma 1	Homo sapiens	19-30
7671564-8	1995	A similar dissociation was noted between fluid and lithium excretion when arginine vasopressin was superimposed on mannitol infusion with reductions in the fractional clearance of free water (12.7% +/- 1.0% to -0.9% +/- 0.7%, P &lt; 0.001) and flow rate (18.6% +/- 1.5% to 5.7% +/- 1.0%; P &lt; 0.001), while the fractional excretion of lithium showed a significant increase (28.4% +/- 1.7% to 33.1% +/- 2.4%; P &lt; 0.05).	Water	185-190	arginine vasopressin	Homo sapiens	83-94
7473422-7	1995	These results indicate that the erythrocyte and proximal tubule water channel, CHIP28, is not present in sperm membranes but that sperm membrane glucose transporters may have a secondary water channel function.	Water	64-69	aquaporin 1 (Colton blood group)	Homo sapiens	79-85
7473422-7	1995	These results indicate that the erythrocyte and proximal tubule water channel, CHIP28, is not present in sperm membranes but that sperm membrane glucose transporters may have a secondary water channel function.	Water	187-192	aquaporin 1 (Colton blood group)	Homo sapiens	79-85
7491270-1	1995	Permeabilities to glycerol and small non-electrolytes of three Aquaporin 1 CHIP (AQP1) water channels were measured in AQP1 cRNA-injected Xenopus laevis oocytes and in human AQP1 channels reconstituted in proteoliposomes.	Water	87-92	aquaporin 1 (Colton blood group)	Homo sapiens	119-123
7630141-3	1995	The purpose of this study was to examine the effects of intraluminal administration of a new substituted PYY (22-36) analog on intestinal absorption of electrolytes and water.	Water	169-174	peptide YY	Homo sapiens	105-108
7630141-11	1995	We are describing for the first time a synthetic peptide analog of PYY that produces significant water and electrolyte absorption in the ileum and colon when administered luminally.	Water	97-102	peptide YY	Homo sapiens	67-70
7491270-8	1995	In AQP1 cRNA-injected oocytes and in proteoliposomes, the value of the glycerol reflection coefficient was 0.74-0.80, indicating that water and glycerol share the same pathway.	Water	134-139	aquaporin 1 (Colton blood group)	Homo sapiens	3-7
7560756-4	1995	ANGII injection into the MnPO induced water and sodium intake, and natriuretic, diuretic, pressor and tachycardic responses.	Water	38-43	angiotensinogen	Rattus norvegicus	0-5
7667423-1	1995	Exogenous angiotensin II (AII) administration produces a robust drinking response, even in water-satiated rats.	Water	91-96	angiotensinogen	Rattus norvegicus	10-24
7667423-1	1995	Exogenous angiotensin II (AII) administration produces a robust drinking response, even in water-satiated rats.	Water	91-96	angiotensinogen	Rattus norvegicus	26-29
7667423-8	1995	MSG-treated rats drank significantly less water after 100 ug/kg, sc AII than control rats.	Water	42-47	angiotensinogen	Rattus norvegicus	68-71
7483671-5	1995	Reaction of the BP, 6-FBP, 6-ClBP and 6-BrBP radical cation perchlorates with H2O produced BP 1,6-, 3,6- and 6,12- dione, whereas 6-CH3BP.+ClO4-.AgI yielded 6-CH2OHBP.	Water	78-81	ECB2	Homo sapiens	22-25
7483671-7	1995	When BP.+ClO4-.AgI and 6-FBP.+ClO4-.AgI were reacted with NaOAc in H2O/CH3CN (9:1), 6-OAcBP was formed, in addition to the quinones.	Water	67-70	ECB2	Homo sapiens	25-28
7797503-3	1995	We investigated the structure of hPTH(1-37) in H2O/buffer solution under near physiological conditions, that is pH 6.0 and 270 mM salt, by circular dichroism, ultracentrifugation, nuclear magnetic resonance spectroscopy, and molecular dynamics calculations.	Water	47-50	parathyroid hormone	Homo sapiens	33-37
7791219-9	1995	These two water molecules are not located in the structure of beef liver catalase, but are supposed to account for the catalytic mechanism.	Water	10-15	catalase	Homo sapiens	73-81
7612670-1	1995	In the presence of excess water, enzymatic activity of phospholipase A2 (PLA2) depends on the physical state of the lipid substrate.	Water	26-31	phospholipase A2 group IB	Homo sapiens	55-71
7612670-1	1995	In the presence of excess water, enzymatic activity of phospholipase A2 (PLA2) depends on the physical state of the lipid substrate.	Water	26-31	phospholipase A2 group IB	Homo sapiens	73-77
8948435-5	1995	Recombinant C4BP bound C4(H2O) (used instead of C4b) equally as well as native C4BP, functioned equally as well as factor I cofactor in the degradation of C4(H2O) and bound to SAP.	Water	26-29	complement component 4 binding protein alpha	Homo sapiens	12-16
8948435-5	1995	Recombinant C4BP bound C4(H2O) (used instead of C4b) equally as well as native C4BP, functioned equally as well as factor I cofactor in the degradation of C4(H2O) and bound to SAP.	Water	158-161	complement component 4 binding protein alpha	Homo sapiens	12-16
7541941-0	1995	Vasopressin increases AQP-CD water channel in apical membrane of collecting duct cells in Brattleboro rats.	Water	29-34	arginine vasopressin	Rattus norvegicus	0-11
7573805-2	1995	In contrast, in alcoholics during withdrawal from alcohol, vasopressin release is stimulated, resulting in water retention (antidiuresis) and dilutional hyponatremia.	Water	107-112	arginine vasopressin	Homo sapiens	59-70
7779774-3	1995	With a view to identify domain-domain interactions within this region, the gamma-B fragment of C1s, obtained by limited proteolysis with plasmin, was chemically cross-linked with the water-soluble carbodiimide 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide; then cross-linked peptides were isolated after CNBr cleavage and thermolytic digestion.	Water	183-188	complement C1s	Homo sapiens	95-98
7541941-3	1995	In rats given vasopressin 15 min before death, the number of immunogold particles for AQP-CD in the apical membrane increased significantly (P &lt; 0.002) from 1.8 +/- 0.2 to 10.0 +/- 0.4/microns with a significant decrease (P &lt; 0.05) of cytoplasmic labeling from 32.6 +/- 6.4 to 24.6 +/- 5.6/microns 2, indicating that AQP-CD is the vasopressin-regulated water channel predicted by the "shuttle" hypothesis.	Water	359-364	arginine vasopressin	Rattus norvegicus	14-25
8547853-10	1995	The water-soluble fraction contained a substance with hRf = 20 which was the same as that of authentic SMFA.	Water	4-9	CD59 molecule (CD59 blood group)	Homo sapiens	54-62
7611515-2	1995	ANG II (10 ng) microinjected into the OCPLT significantly increased water consumption but did not induce intake of a hypertonic (3%) NaCl solution.	Water	68-73	angiotensinogen	Homo sapiens	0-6
7611515-6	1995	These findings suggest that water intake produced by microinjection of ANG II into the OCPLT is mediated by AT1 receptors uniquely and that, in contrast to other regions of the brain, these receptors do not induce salt intake when stimulated by ANG II.	Water	28-33	angiotensinogen	Homo sapiens	71-77
7548538-6	1995	Compared with Escherichia coli LPS, the phenol/water extract of B. fragilis was sevenfold more active in the LAL assay and marginally less active (five-to seven-fold) in the bioassay for TNF induction.	Water	47-52	tumor necrosis factor	Homo sapiens	187-190
7670390-0	1995	[Autacoids regulate regeneration of water-impermeable epithelium after exposure to vasopressin].	Water	36-41	arginine vasopressin	Homo sapiens	83-94
7593010-4	1995	Fibrinogen may undergo unfolding or spreading on the TFE-treated surfaces to minimize interfacial free energy (in water) and maximize protein-surface interactions.	Water	114-119	fibrinogen beta chain	Homo sapiens	0-10
7641972-7	1995	Water content, collagen content, neutrophil counts, elastase activity and collagenase activity of the cervix were increased by IL-8, but they did not increase by IL-8 with UTI.	Water	0-5	interleukin-8	Oryctolagus cuniculus	127-131
15299307-1	1995	Studies on the low-humidity (88%) forms of tetragonal and monoclinic lysozyme, resulting from water-mediated transformations, have provided a wealth of information on the variability in protein hydration, its structural consequences and the water structure associated with proteins, in addition to facilitating the delineation of the rigid and the flexible regions in the protein molecule and the invariant features in its hydration shell.	Water	94-99	lysozyme	Homo sapiens	69-77
7670125-3	1995	Treatment with TRH resulted in significantly decreased hypothalamic oxytocin content in both euhydrated (i.e. given tap water ad libitum) and salt-loaded rats.	Water	120-125	nuclear RNA export factor 1	Rattus norvegicus	116-119
7670125-4	1995	In rats drinking tap water, neurohypophysial oxytocin content decreased.	Water	21-26	nuclear RNA export factor 1	Rattus norvegicus	17-20
8685078-2	1995	CLS.H2O given by the oral route (300 mg kg(-1)) significantly reduced neutrophil infiltration into the airway lumen induced by intratracheal injection of IL-1 beta in rats.	Water	4-7	interleukin 1 beta	Rattus norvegicus	154-163
7540151-0	1995	Identification of Rab3-, Rab5a- and synaptobrevin II-like proteins in a preparation of rat kidney vesicles containing the vasopressin-regulated water channel.	Water	144-149	RAB3A, member RAS oncogene family	Rattus norvegicus	18-22
7540151-0	1995	Identification of Rab3-, Rab5a- and synaptobrevin II-like proteins in a preparation of rat kidney vesicles containing the vasopressin-regulated water channel.	Water	144-149	RAB5A, member RAS oncogene family	Rattus norvegicus	25-30
7540151-0	1995	Identification of Rab3-, Rab5a- and synaptobrevin II-like proteins in a preparation of rat kidney vesicles containing the vasopressin-regulated water channel.	Water	144-149	arginine vasopressin	Rattus norvegicus	122-133
7540151-1	1995	According to the "shuttle hypothesis", vasopressin increases the water permeability of renal epithelial cells by exocytotic fusion of vesicles containing the water channel AQP-CD with the apical plasma membrane, whereas withdrawal of vasopressin results in endocytotic uptake of AQP-CD.	Water	65-70	arginine vasopressin	Rattus norvegicus	39-50
7540151-1	1995	According to the "shuttle hypothesis", vasopressin increases the water permeability of renal epithelial cells by exocytotic fusion of vesicles containing the water channel AQP-CD with the apical plasma membrane, whereas withdrawal of vasopressin results in endocytotic uptake of AQP-CD.	Water	158-163	arginine vasopressin	Rattus norvegicus	39-50
7794949-0	1995	Calcium ions and interactions of pulmonary surfactant proteins SP-B and SP-C with phospholipids in spread monolayers at the air/water interface.	Water	128-133	surfactant protein C	Homo sapiens	72-76
7631311-8	1995	The results suggest a water exclusion effect, inducing cryoprecipitation of otherwise soluble fibrin/fibrinogen complexes.	Water	22-27	fibrinogen beta chain	Homo sapiens	101-111
7789625-6	1995	Infusion of 1.2 pmol.kg-1.min-1 GLP-I with 20 g glucose (10% dextrose in water) injected intravenously over 60 min enhanced plasma responses of immunoreactive CP; the mean incremental areas under concentration curves (0-60 min) increased sixfold, but the glycemic excursion was not affected.	Water	73-78	insulin	Homo sapiens	159-161
7742317-0	1995	Structure and rotational dynamics of fluorescently labeled insulin in aqueous solution and at the amphiphile-water interface of reversed micelles.	Water	109-114	insulin	Homo sapiens	59-66
7572202-7	1995	The decrease of ANP after exercise was slow, which may be connected to the regulation of water and electrolytes.	Water	89-94	natriuretic peptide A	Homo sapiens	16-19
15299307-1	1995	Studies on the low-humidity (88%) forms of tetragonal and monoclinic lysozyme, resulting from water-mediated transformations, have provided a wealth of information on the variability in protein hydration, its structural consequences and the water structure associated with proteins, in addition to facilitating the delineation of the rigid and the flexible regions in the protein molecule and the invariant features in its hydration shell.	Water	241-246	lysozyme	Homo sapiens	69-77
7539214-2	1995	Other membrane proteins, including transporters and cystic fibrosis transmembrane conductance regulator, have also revealed a finite permeability to water.	Water	149-154	CF transmembrane conductance regulator	Homo sapiens	52-103
7537761-0	1995	Water channels encoded by mutant aquaporin-2 genes in nephrogenic diabetes insipidus are impaired in their cellular routing.	Water	0-5	aquaporin 2 S homeolog	Xenopus laevis	33-44
7590000-5	1995	RESULTS: C7-sorbin was the minimal peptide able to decrease duodenal VIP-stimulated fluxes of water, Na and bicarbonate.	Water	94-99	vasoactive intestinal peptide	Rattus norvegicus	69-72
7620857-1	1995	In the vasopressin-stimulated inner medullary collecting duct (IMCD), urea is transported through a pathway which is distinct from a water channel.	Water	133-138	arginine vasopressin	Homo sapiens	7-18
7537761-2	1995	Recently, we reported mutations in the gene encoding the water channel of the collecting duct, aquaporin-2 (AQP-2) causing an autosomal recessive form of nephrogenic diabetes insipidus (NDI).	Water	57-62	aquaporin 2 S homeolog	Xenopus laevis	95-106
7537761-2	1995	Recently, we reported mutations in the gene encoding the water channel of the collecting duct, aquaporin-2 (AQP-2) causing an autosomal recessive form of nephrogenic diabetes insipidus (NDI).	Water	57-62	aquaporin 2 S homeolog	Xenopus laevis	108-113
7537761-3	1995	Expression of these mutant AQP-2 proteins (Gly64Arg, Arg187Cys, Ser216Pro) in Xenopus oocytes revealed nonfunctional water channels.	Water	117-122	aquaporin 2 S homeolog	Xenopus laevis	27-32
7537761-4	1995	Here we report further studies into the inability of these missense AQP-2 proteins to facilitate water transport in Xenopus oocytes.	Water	97-102	aquaporin 2 S homeolog	Xenopus laevis	68-73
7537761-9	1995	Therefore, we conclude that in Xenopus oocytes the inability of Gly64-Arg, Arg187Cys or Ser216Pro substituted AQP-2 proteins to facilitate water transport is caused by an impaired routing to the plasma membrane.	Water	139-144	aquaporin 2 S homeolog	Xenopus laevis	110-115
7740426-11	1995	The prosecretory response of vasoactive intestinal polypeptide on ileal fluxes of water and electrolytes was unchanged, whereas the proabsorptive response to norepinephrine increased after this model of autotransplantation.	Water	82-87	vasoactive intestinal peptide	Canis lupus familiaris	29-62
7740582-1	1995	BACKGROUND AND PURPOSE: Atrial natriuretic peptide (ANP) and arginine vasopressin regulate brain water and electrolytes.	Water	97-102	arginine vasopressin	Rattus norvegicus	70-81
7643964-4	1995	In addition, four weeks following transfer to toxicant-free water after exposure to 1 mg monocrotophos, nile tilapia fish brain regained 95% of control AChE activity.	Water	60-65	acetylcholinesterase	Oreochromis niloticus	152-156
7711039-0	1995	1H NMR of A beta amyloid peptide congeners in water solution.	Water	46-51	amyloid beta precursor protein	Homo sapiens	10-16
7718556-4	1995	CD spectra and two-dimensional NMR experiments were performed to investigate the KR-ET-1 three-dimensional structure in water in the carboxylic acid and carboxylate states.	Water	120-125	endothelin 1	Homo sapiens	84-88
7733894-7	1995	Furthermore, the helical structure of both native and depalmitoylated SP-C in dodecylphosphocholine micelles is very resistant to thermal denaturation, exhibiting ordered structure at 90 degrees C. The alpha-helical content grossly parallels the peptide-induced acceleration of the spreading of phospholipids at an air/water interface and the increase of surface pressure.	Water	319-324	surfactant protein C	Homo sapiens	70-74
7733868-2	1995	We demonstrated here for the first time that exposure of HeLa cells to a hypotonic medium (30% growth medium and 70% water) prominently induced the binding activity of the heat shock transcription factor (HSF).	Water	117-122	interleukin 6	Homo sapiens	172-203
7733868-2	1995	We demonstrated here for the first time that exposure of HeLa cells to a hypotonic medium (30% growth medium and 70% water) prominently induced the binding activity of the heat shock transcription factor (HSF).	Water	117-122	interleukin 6	Homo sapiens	205-208
7744069-6	1995	The data suggest that the hydrophobic C-terminal part allows the anchorage of SP-C in the lipid bilayer in such a manner that the N-terminal domain adopts an optimal conformation and orientation for the rapid adsorption of phospholipids at the air/water interface, and/or that a membrane-spanning helix as such is needed for this activity.	Water	248-253	surfactant protein C	Homo sapiens	78-82
7733406-3	1995	The experiment was performed at the 10th to 12th wk in conscious, chronically instrumented rats hydrated with tap water (2% body wt).	Water	114-119	nuclear RNA export factor 1	Rattus norvegicus	110-113
7726835-5	1995	Proliferating cells in low density cultures had lower pHi and NHE-1 activity (per litre of cell water) than contact inhibited confluent cultures.	Water	96-101	solute carrier family 9 member A1	Homo sapiens	62-67
7537470-6	1995	In conclusion, the mechanism of increased microvessel permeability in response to substance P appears to be the result of receptor-mediated increase in nitric oxide production and formation of water-filled convective pathways presumably located between adjacent endothelial cells.	Water	193-198	tachykinin precursor 1	Homo sapiens	82-93
7723032-2	1995	Two additional simulations were performed on truncated SP-C with a five-residue N-terminal deletion at 300 K and 500 K in water, the high temperature run in order to increase the rate of peptide denaturation.	Water	122-127	surfactant protein C	Homo sapiens	55-59
7723032-3	1995	Indications of destabilization appear in chloroform during 1 ns while the SP-C alpha-helix is remarkably stable during 1 ns in methanol and water.	Water	140-145	surfactant protein C	Homo sapiens	74-78
7711446-0	1995	Participation of the kidney in the kinetics of arginine vasopressin in the water-loaded rat.	Water	75-80	arginine vasopressin	Rattus norvegicus	56-67
7540052-4	1995	Together with the low activation energy of human spermatozoa for Lp, this suggests that CHIP28 water channel may be present in the plasma membrane of human spermatozoa.	Water	95-100	aquaporin 1 (Colton blood group)	Homo sapiens	88-94
7541280-7	1995	administration of 25 pmol AII evoked an increase in mean arterial blood pressure (MAP) and water intake behaviour, accompanied by a transient bradycardia, whereas 25 pmol [MePhe7]NKB caused a transient increase in MAP and heart rate (HR) concurrently with marked wet dog shake behaviour.	Water	91-96	angiotensinogen	Rattus norvegicus	26-29
7793338-0	1995	Age-associated alterations in thirst and arginine vasopressin in response to a water or sodium load.	Water	79-84	arginine vasopressin	Homo sapiens	50-61
7627260-4	1995	The plasma levels of AVP were increased after water loadings.	Water	46-51	arginine vasopressin	Homo sapiens	21-24
7627260-7	1995	The water loading test itself stimulated the release of AVP and a suppression of the renin-aldosterone system played a more important role in natriuresis than ANP in this case.	Water	4-9	arginine vasopressin	Homo sapiens	56-59
7883561-2	1995	The mean 3H concentration was found to be 1.4 +/- 0.4 Bq L-1 and 1.0 +/- 0.4 Bq L-1 (combustion water) for free water 3H and organically-bound 3H, respectively, excluding the abnormally high data of one city.	Water	96-101	immunoglobulin kappa variable 1-16	Homo sapiens	57-68
7883561-2	1995	The mean 3H concentration was found to be 1.4 +/- 0.4 Bq L-1 and 1.0 +/- 0.4 Bq L-1 (combustion water) for free water 3H and organically-bound 3H, respectively, excluding the abnormally high data of one city.	Water	112-117	immunoglobulin kappa variable 1-16	Homo sapiens	57-68
7603640-4	1995	We gavaged simulated tap water, containing a low level of radioactive soluble aluminum (26Al), into the stomachs of rats.	Water	25-30	nuclear RNA export factor 1	Rattus norvegicus	21-24
7778097-4	1995	In particular, ANF seems to intensely stimulate the GCp activity along the lateral membranes of the epithelial cells delimiting enlarged intercellular spaces, which are probably dilated for the transport of water and solutes.	Water	207-212	natriuretic peptide A	Homo sapiens	15-18
7778097-4	1995	In particular, ANF seems to intensely stimulate the GCp activity along the lateral membranes of the epithelial cells delimiting enlarged intercellular spaces, which are probably dilated for the transport of water and solutes.	Water	207-212	golgin B1	Homo sapiens	52-55
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	29-34	interleukin 1 beta	Homo sapiens	106-124
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	29-34	interleukin 1 beta	Homo sapiens	126-136
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	64-69	interleukin 1 beta	Homo sapiens	106-124
7624014-1	1995	Angiotensin II (ANGII) is known to activate neurons in the subfornical organ (SFO) of mammals and birds and this activation is regarded as the basis for the ANGII induced increase in water intake.	Water	183-188	angiotensinogen	Homo sapiens	0-14
7624014-1	1995	Angiotensin II (ANGII) is known to activate neurons in the subfornical organ (SFO) of mammals and birds and this activation is regarded as the basis for the ANGII induced increase in water intake.	Water	183-188	angiotensinogen	Homo sapiens	16-21
7624014-1	1995	Angiotensin II (ANGII) is known to activate neurons in the subfornical organ (SFO) of mammals and birds and this activation is regarded as the basis for the ANGII induced increase in water intake.	Water	183-188	angiotensinogen	Homo sapiens	157-162
7624014-3	1995	These data, in combination with the histochemical detection of NO synthase in the duck SFO, demonstrate the involvement of NO in SFO mediated responses and might represent the cellular basis for the observed opposite effects of ANGII and NO on water intake.	Water	244-249	angiotensinogen	Homo sapiens	228-233
7709417-8	1995	In contrast, administration of anti-IL-1 beta and ZnPP into the left cerebral ventricle attenuated the postischemic increase of brain water content and decreased the size of brain infarction (83.5 +/- 2.0% and 79.9 +/- 2.0% in the dorsal and ventral parts of the caudate putamen, respectively, in rats treated with 10 micrograms anti-IL-1 beta; P &lt; .01).	Water	134-139	interleukin 1 beta	Rattus norvegicus	36-45
7709417-10	1995	CONCLUSIONS: Application of rhIL-1 beta augmented the increase of brain water content, and application of anti-IL-1 beta depressed the increase of water content.	Water	72-77	interleukin 1 beta	Rattus norvegicus	30-39
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	64-69	interleukin 1 beta	Homo sapiens	126-136
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	64-69	interleukin 1 beta	Homo sapiens	106-124
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	64-69	interleukin 1 beta	Homo sapiens	126-136
7890036-0	1995	Native like structure and stability of apo AI in a n-propanol/water solution as determined by 13C NMR.	Water	62-67	apolipoprotein A1	Homo sapiens	39-45
7893740-10	1995	On the other hand, SP-C had a main beta-sheet secondary structure in all the assayed TFE/water mixtures, with 30-40% alpha-helix and around 50% beta-structure.	Water	89-94	surfactant protein C	Homo sapiens	19-23
7535000-2	1995	In proximal tubules and thin descending limbs of normal kidneys, the high transepithelial water permeability of these segments is due to the presence of the water channel protein, aquaporin-CHIP (AQP-CHIP, i.e., AQP-1).	Water	90-95	aquaporin 1 (Colton blood group)	Homo sapiens	180-194
7535000-2	1995	In proximal tubules and thin descending limbs of normal kidneys, the high transepithelial water permeability of these segments is due to the presence of the water channel protein, aquaporin-CHIP (AQP-CHIP, i.e., AQP-1).	Water	90-95	aquaporin 1 (Colton blood group)	Homo sapiens	196-204
7535000-2	1995	In proximal tubules and thin descending limbs of normal kidneys, the high transepithelial water permeability of these segments is due to the presence of the water channel protein, aquaporin-CHIP (AQP-CHIP, i.e., AQP-1).	Water	157-162	aquaporin 1 (Colton blood group)	Homo sapiens	180-194
7535000-2	1995	In proximal tubules and thin descending limbs of normal kidneys, the high transepithelial water permeability of these segments is due to the presence of the water channel protein, aquaporin-CHIP (AQP-CHIP, i.e., AQP-1).	Water	157-162	aquaporin 1 (Colton blood group)	Homo sapiens	196-204
7736706-3	1995	We therefore studied the effect of a mildly vasoconstrictive dose of angiotensin II on tubular handling of water, sodium (Na+) and lithium (Li+) in rats by means of free-flow micropuncture at the late proximal tubule and the early distal tubule.	Water	107-112	angiotensinogen	Rattus norvegicus	69-83
7606386-1	1995	A novel total enzymatic synthesis of [Leu]- and [Met]-enkephalin derivatives was accomplished in low-water content systems at a preparative scale.	Water	101-106	proopiomelanocortin	Homo sapiens	49-64
24394272-3	1995	Generally, GH increases the amount of body cell mass and extracellular water and decreases body fat.	Water	71-76	growth hormone 1	Homo sapiens	11-13
7542715-2	1995	Intravenous injections of water extracts of P. betle inflorescence (PBE), eugenol, and safrole in rats induced hypotensive and bradycardiac effects, whereas both intraarterial and intrathecal injections of PBE, eugenol and safrole resulted in hypotensive and tachycardiac effects.	Water	26-31	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Rattus norvegicus	68-71
7542715-2	1995	Intravenous injections of water extracts of P. betle inflorescence (PBE), eugenol, and safrole in rats induced hypotensive and bradycardiac effects, whereas both intraarterial and intrathecal injections of PBE, eugenol and safrole resulted in hypotensive and tachycardiac effects.	Water	26-31	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Rattus norvegicus	206-209
7616606-1	1995	In the choroid plexus carbonic anhydrase II (CAII) supports the transport of bicarbonate ions, sodium ions, and water from blood to the CSF, and in the myelin sheath CAII supports compaction of myelin by stimulating cotransport of ions and water out from between the myelin membranes.	Water	112-117	carbonic anhydrase 2	Mus musculus	22-43
7616606-1	1995	In the choroid plexus carbonic anhydrase II (CAII) supports the transport of bicarbonate ions, sodium ions, and water from blood to the CSF, and in the myelin sheath CAII supports compaction of myelin by stimulating cotransport of ions and water out from between the myelin membranes.	Water	112-117	carbonic anhydrase 2	Mus musculus	45-49
7616606-1	1995	In the choroid plexus carbonic anhydrase II (CAII) supports the transport of bicarbonate ions, sodium ions, and water from blood to the CSF, and in the myelin sheath CAII supports compaction of myelin by stimulating cotransport of ions and water out from between the myelin membranes.	Water	240-245	carbonic anhydrase 2	Mus musculus	45-49
7616606-1	1995	In the choroid plexus carbonic anhydrase II (CAII) supports the transport of bicarbonate ions, sodium ions, and water from blood to the CSF, and in the myelin sheath CAII supports compaction of myelin by stimulating cotransport of ions and water out from between the myelin membranes.	Water	240-245	carbonic anhydrase 2	Mus musculus	166-170
7742711-7	1995	Because of this, and slightly lower VP levels at hyperbaria, a decrease in VP in response to the water load was significantly detectable only at 1 atm abs during the daytime.	Water	97-102	arginine vasopressin	Homo sapiens	36-38
7742711-7	1995	Because of this, and slightly lower VP levels at hyperbaria, a decrease in VP in response to the water load was significantly detectable only at 1 atm abs during the daytime.	Water	97-102	arginine vasopressin	Homo sapiens	75-77
7532304-0	1995	Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.	Water	22-27	arginine vasopressin	Rattus norvegicus	0-11
7532004-9	1995	In reconstituted proteoliposomes, deglycosylated CHIP28 had a single channel water permeability (pf) of 3.1 x 10(-14) cm3/s (10 degrees C), not different from that of 3.2 x 10(-14) cm3/s for native CHIP28.	Water	77-82	aquaporin 1 (Colton blood group)	Homo sapiens	49-55
7873554-6	1995	A hitherto unobserved water molecule is hydrogen bonded to the pteridine N5 and O4 in both molecules of the asymmetric unit of the folate complex (but not the 5dfol or ddTHF complexes), supporting the hypothesis that N5 protonation of bound substrate, an important step of the DHFR reaction, occurs by way of such a water molecule.	Water	22-27	dihydrofolate reductase	Escherichia coli	277-281
7532304-1	1995	Water excretion by the kidney is regulated by the peptide hormone vasopressin.	Water	0-5	arginine vasopressin	Rattus norvegicus	66-77
7532304-2	1995	Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed from collecting duct urine to blood.	Water	26-31	arginine vasopressin	Rattus norvegicus	0-11
7532304-2	1995	Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed from collecting duct urine to blood.	Water	95-100	arginine vasopressin	Rattus norvegicus	0-11
7532304-6	1995	Here, we test the hypothesis that vasopressin increases cellular water permeability by inducing exocytosis of AQP-CD-laden vesicles, transferring water channels from IVs to APM.	Water	65-70	arginine vasopressin	Rattus norvegicus	34-45
7532304-9	1995	Vasopressin exposure induced increases in water permeability and the absolute labeling density of AQP-CD in the APM.	Water	42-47	arginine vasopressin	Rattus norvegicus	0-11
7761626-8	1995	It can be suggested that NTS-DMN complex could be a site of action of VIP since injection of VIP in it produced a more pronounced inhibitory effect on water and Ala absorption than that produced by VIP injection in the LV.	Water	151-156	vasoactive intestinal peptide	Rattus norvegicus	70-73
7761626-4	1995	Water movement was not affected by VIP injection in the lateral ventricle, while VIP injections in the NTS-DMN inhibited significantly (P &lt; 0.05) jejunal water absorption by 10-12%.	Water	157-162	vasoactive intestinal peptide	Rattus norvegicus	81-84
7761626-8	1995	It can be suggested that NTS-DMN complex could be a site of action of VIP since injection of VIP in it produced a more pronounced inhibitory effect on water and Ala absorption than that produced by VIP injection in the LV.	Water	151-156	vasoactive intestinal peptide	Rattus norvegicus	93-96
7532304-11	1995	Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability.	Water	173-178	arginine vasopressin	Rattus norvegicus	28-39
7761626-8	1995	It can be suggested that NTS-DMN complex could be a site of action of VIP since injection of VIP in it produced a more pronounced inhibitory effect on water and Ala absorption than that produced by VIP injection in the LV.	Water	151-156	vasoactive intestinal peptide	Rattus norvegicus	93-96
7532304-12	1995	We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.	Water	43-48	arginine vasopressin	Rattus norvegicus	17-28
7532304-12	1995	We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.	Water	136-141	arginine vasopressin	Rattus norvegicus	17-28
7720345-2	1995	It has been demonstrated that parathyroid hormone can increase adenylate cyclase activity in the rat papilla, produce a small antidiuretic effect and in vitro can interfere with the action of arginine vasopressin on water transport.	Water	216-221	parathyroid hormone	Rattus norvegicus	30-49
7836427-5	1995	(i) When a single cis-carbon-carbon double bond (delta) is incorporated into a saturated diacylphosphatidylcholine molecule at any position within the central segment of the long sn-2 acyl chain, the resulting monoenoic lipid molecules will, in excess water, exhibit reduced phase transition temperature (Tm) and transition enthalpy (delta H) as they undergo the gel to liquid-crystalline phase transition.	Water	252-257	solute carrier family 38 member 5	Homo sapiens	179-183
7864076-4	1995	The ANG II-stimulated release of the water-soluble metabolites of PC breakdown (phosphorylcholine and choline) was blocked by ANF and SNP.	Water	37-42	angiotensinogen	Rattus norvegicus	4-10
7746497-3	1995	Three days of water deprivation significantly increased plasma arginine vasopressin and markedly potentiated the expression of PACAP mRNA in ARC.	Water	14-19	arginine vasopressin	Rattus norvegicus	72-83
7531248-1	1995	Water oxygen-17 spin relaxation was used to study hydration and dynamics of the globular proteins bovine pancreatic trypsin inhibitor (BPTI) and ubiquitin in aqueous solution.	Water	0-5	trophoblast Kunitz domain protein 1	Bos taurus	116-133
7531249-1	1995	Water deuteron (2H) spin relaxation was used to study hydrogen exchange, hydration, and protein dynamics in aqueous solutions of the globular proteins bovine pancreatic trypsin inhibitor (BPTI) and ubiquitin.	Water	0-5	trophoblast Kunitz domain protein 1	Bos taurus	169-186
7864103-3	1995	Fat-free mass (FFM) and total body water increased more in the GH group.	Water	35-40	growth hormone 1	Homo sapiens	63-65
7720345-2	1995	It has been demonstrated that parathyroid hormone can increase adenylate cyclase activity in the rat papilla, produce a small antidiuretic effect and in vitro can interfere with the action of arginine vasopressin on water transport.	Water	216-221	arginine vasopressin	Rattus norvegicus	201-212
7712167-1	1995	We have previously shown that peripheral injection of bradykinin in combination with the kininase II inhibitor, captopril, to rats produces a robust water intake.	Water	149-154	angiotensin I converting enzyme	Rattus norvegicus	89-100
7858731-0	1995	Impaired response of atrial natriuretic peptide to acute water load in obesity and in anorexia nervosa.	Water	57-62	natriuretic peptide A	Homo sapiens	21-47
7858731-6	1995	The response of ANP to acute water load was markedly blunted in anorexia nervosa and in obesity (delta % = 232% in control group, 14% in anorexia nervosa and 21% in obesity.	Water	29-34	natriuretic peptide A	Homo sapiens	16-19
7716222-2	1995	Intraperitoneal (ip) injection of IL-1 beta suppressed food and water intake and elevated rectal temperature.	Water	64-69	interleukin 1 beta	Rattus norvegicus	34-43
7716222-3	1995	The suppressive effect of IL-1 beta on water intake was converted to an increase when 4.0 mM Rg1 was continuously infused into the third cerebroventricle (ICV) at a rate of 0.966 microliters/h.	Water	39-44	interleukin 1 beta	Rattus norvegicus	26-35
7716222-6	1995	These results suggest that sustained ICV infusion of Rg1 may modulate the effects of IL-1 beta on ingestive behaviors, i.e., increase in water intake and sustained decrease in food intake, resulting in a lowering of body temperature.	Water	137-142	interleukin 1 beta	Rattus norvegicus	85-94
7882126-7	1995	Mean PFM strength was 18.1 cm H2O.	Water	30-33	msh homeobox 2	Homo sapiens	5-8
7539496-0	1995	The AQP2 water channel: effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats.	Water	9-14	arginine vasopressin	Rattus norvegicus	34-45
7539496-7	1995	This behavior is consistent with the idea that AQP2 is the vasopressin-sensitive water channel.	Water	81-86	arginine vasopressin	Rattus norvegicus	59-70
7539501-1	1995	Aquaporin CHIP, a 28 kDa channel forming protein, has been proposed to function as water channel in both erythrocyte and kidney proximal tubule.	Water	83-88	aquaporin 1 (Colton blood group)	Homo sapiens	0-14
7894018-3	1995	Expression of btg-26 is induced in leaf tissue within 72 h of withholding water.	Water	74-79	aldehyde dehydrogenase family 7 member A1	Brassica napus	14-20
18966220-4	1995	The polymer used in this study was Polymin Water-Free and its complexation with Hg(II), Cd(II), Pb(II), Co(II) and Ni(II) was successfully modelled.	Water	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
7827090-8	1995	In both the rhodopsin and bathorhodopsin models, we have included a structural water molecule hydrogen bonded with the Schiff base to account for the high C = N stretching vibrations previously observed.	Water	79-84	rhodopsin	Homo sapiens	12-21
7814372-11	1995	It is concluded that CETP converts rHDL to small, TG-enriched, apoA-I-depleted particles with increased lipid-water interfacial hydration and less ordered phospholipid packing.	Water	110-115	cholesteryl ester transfer protein	Homo sapiens	21-25
7814372-11	1995	It is concluded that CETP converts rHDL to small, TG-enriched, apoA-I-depleted particles with increased lipid-water interfacial hydration and less ordered phospholipid packing.	Water	110-115	apolipoprotein A1	Homo sapiens	63-69
7712167-3	1995	Water intake increases with dose of dose of bradykinin, but has an inverted U-shaped relationship with dose of kininase II inhibitor.	Water	0-5	angiotensin I converting enzyme	Rattus norvegicus	111-122
7840327-0	1995	Gut-brain signaling of water absorption inhibits vasopressin in rats.	Water	23-28	arginine vasopressin	Rattus norvegicus	49-60
7810534-8	1995	In PNS rats, plasma AVP was significantly higher than in control rats (control 0.77 +/- 0.10 pg/mL v PNS 2.13 +/- 0.42 pg/mL; P &lt; 0.005, n = 12), even though there were no differences in plasma osmolality (control 292.0 +/- 2.0 mOsm/kg H2O v PNS 290.3 +/- 2.5 mOsm/kg H2O; P = NS, n = 12) or serum sodium concentration (control 142.7 +/- 0.7 v PNS 142.1 +/- 1.1; PNS, n = 12).	Water	239-242	arginine vasopressin	Rattus norvegicus	20-23
7810534-8	1995	In PNS rats, plasma AVP was significantly higher than in control rats (control 0.77 +/- 0.10 pg/mL v PNS 2.13 +/- 0.42 pg/mL; P &lt; 0.005, n = 12), even though there were no differences in plasma osmolality (control 292.0 +/- 2.0 mOsm/kg H2O v PNS 290.3 +/- 2.5 mOsm/kg H2O; P = NS, n = 12) or serum sodium concentration (control 142.7 +/- 0.7 v PNS 142.1 +/- 1.1; PNS, n = 12).	Water	271-274	arginine vasopressin	Rattus norvegicus	20-23
7840248-1	1995	Prolonged fluid restriction in rats is accompanied by functional modifications of the terminal part of the inner medullary collecting duct (IMCD) revealed by a sustained increase in arginine vasopressin (AVP)-independent transepithelial osmotic water permeability (PTE) in vitro.	Water	245-250	arginine vasopressin	Rattus norvegicus	204-207
7840248-6	1995	However, when IMCDs of thirsted rats were exposed to AVP in vitro, their transcellular Posm (36.0 +/- 2.4 microns/s) was significantly smaller than their PTE determined simultaneously (51.8 +/- 7.1 microns/s), suggesting that part of the water flow may follow a paracellular route.	Water	238-243	arginine vasopressin	Rattus norvegicus	53-56
7840327-1	1995	The mechanism for inhibition of vasopressin (AVP) by gastric water infusion was examined in 24- or 48-h dehydrated conscious rats (n = 136 rats, 255 experiments; mean AVP baseline = 6.3 pg/ml).	Water	61-66	arginine vasopressin	Rattus norvegicus	32-43
7565483-5	1995	Lastly, ET-1 is also an autocrine inhibitor of collecting duct sodium and water reabsorption; reduced nephron ET-1 production may result in fluid retention in essential hypertension.	Water	74-79	endothelin 1	Homo sapiens	8-12
7874476-2	1995	In the current debate on the amendment of the European Drinking Water Directive (80/778/EEC) it is proposed that maximum admissible concentrations for pesticides and related products intended for human consumption shall be based on toxicological evidence.	Water	64-69	Ectrodactyly, ectodermal dysplasia, cleft lip/palate, 1	Homo sapiens	88-91
7558688-8	1995	Osmotic transport of H2O through specific H2O channels such as CHIP 28 is hydraulic if the pore is impermeable to the solute and diffusive if the pore is permeable.	Water	21-24	aquaporin 1 (Colton blood group)	Homo sapiens	63-70
7714669-1	1995	We improved our previously devised enzyme immunoassay (FIA) system for basic fibroblast growth factor (bFGF) using biotinylated antibody prepared with sulfosuccinimidyl-6-(biotinamido)hexanoate (NHS-LC-Biotin, Pierce), a water-soluble biotin analogue, with an extended spacer arm.	Water	221-226	fibroblast growth factor 2	Homo sapiens	103-107
7730960-2	1995	The water-soluble model protein, bovine serum albumin (BSA) was microencapsulated into biodegradable poly(D,L-lactic acid) using the following 10 different polymer solvents: acetaldehyde dimethyl acetal, acetone, dichloromethane, dioxane, ethyl acetate, ethyl vinyl ether, nitromethane, tetrahydrofuran, 1,1,1-trichloroethane, and 1,1,2-trichloroethylene.	Water	4-9	albumin	Homo sapiens	40-53
18475677-2	1995	In this system, myeloperoxidase catalyses the conversion of H(2)O(2) and CI(-) to the cytotoxic agent HOCl.	Water	60-65	myeloperoxidase	Homo sapiens	16-31
8546441-0	1995	Validation of extracellular water determination by bioelectrical impedance analysis in growth hormone-deficient adults.	Water	28-33	growth hormone 1	Homo sapiens	87-101
9251753-4	1995	A control group, transplanted with tumor cells received tap drinking water.	Water	69-74	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	56-59
8590217-1	1995	The peptide hormones angiotensin II and vasopressin play a major role in water and electrolyte homeostasis.	Water	73-78	angiotensinogen	Homo sapiens	21-35
8590217-1	1995	The peptide hormones angiotensin II and vasopressin play a major role in water and electrolyte homeostasis.	Water	73-78	arginine vasopressin	Homo sapiens	40-51
8590218-4	1995	There are constitutive water channels (aquaporin 1), which are involved in the bulk of water reabsorption in the kidney.	Water	23-28	aquaporin 1 (Colton blood group)	Homo sapiens	39-50
8590218-4	1995	There are constitutive water channels (aquaporin 1), which are involved in the bulk of water reabsorption in the kidney.	Water	87-92	aquaporin 1 (Colton blood group)	Homo sapiens	39-50
7843759-5	1995	Infusion of angiotensin II into a subset of captopril-treated rats increased pulse pressure and restored blood pressure to levels of water-treated rats.	Water	133-138	angiotensinogen	Rattus norvegicus	12-26
8587436-11	1995	We therefore suggest that the upregulation of medullary ETB in cirrhotic rats is involved int he regulation of water excretion in rats with CCl4-induced cirrhosis.	Water	111-116	C-C motif chemokine ligand 4	Rattus norvegicus	140-144
8577072-6	1995	The EGF signal was transduced through a pathway including protein kinase C. GLUT1 is reported to work as a water transporter, and so EGF can be considered as one of the possible agent which stimulate water transport activity through the corneal endothelial cells.	Water	107-112	LOC521832	Bos taurus	4-7
8577072-6	1995	The EGF signal was transduced through a pathway including protein kinase C. GLUT1 is reported to work as a water transporter, and so EGF can be considered as one of the possible agent which stimulate water transport activity through the corneal endothelial cells.	Water	107-112	LOC521832	Bos taurus	133-136
8745066-1	1995	Pretreatment of rats with intrahypothalamic injections of pituitary adenylate cyclase activating peptide (PACAP) 10 min prior to the injection of neuropeptide Y (NPY) significantly reduced food and water intake during the 4-h measurement period.	Water	198-203	neuropeptide Y	Rattus norvegicus	146-160
7630470-4	1995	A higher production of vasopressin and aldosterone enhances the tubular processes of water and electrolyte reabsorption, stabilising therefore the homeostasis during exercise.	Water	85-90	arginine vasopressin	Homo sapiens	23-34
8538922-8	1995	Likewise the changes in renal handling of sodium and water in response to ET-1 infusion were unaffected by pretreatment with placebo or isradipine, e.g. sodium excretion (-44.6% versus -40.8%), urine flow rate (-49.8% versus -38.9%) and clearance of lithium (-32.0% versus -29.1%).	Water	53-58	endothelin 1	Homo sapiens	74-78
8538922-9	1995	CONCLUSIONS: Intravenous infusion of ET-1 in healthy humans discretely increases diastolic blood pressure and profoundly decreases renal haemodynamics and excretion of sodium and water.	Water	179-184	endothelin 1	Homo sapiens	37-41
8745066-1	1995	Pretreatment of rats with intrahypothalamic injections of pituitary adenylate cyclase activating peptide (PACAP) 10 min prior to the injection of neuropeptide Y (NPY) significantly reduced food and water intake during the 4-h measurement period.	Water	198-203	neuropeptide Y	Rattus norvegicus	162-165
8714353-0	1995	[A morphofunctional analysis of the changes in the Golgi apparatus in the epitheliocytes of the frog bladder under conditions of the vasopressin stimulation of water transport].	Water	160-165	arginine vasopressin	Homo sapiens	133-144
7534555-8	1995	Studies with protoplasts from plants transformed with an antisense construct revealed a water transport capacity of the AthH2 protein.	Water	88-93	plasma membrane intrinsic protein 1B	Arabidopsis thaliana	120-125
8542028-1	1995	The recent identification of the red cell water transporter (AQP1) has led to the identification of the "aquaporins", a new class of membrane proteins which function as water-selective transport proteins and are involved in many physiological processes.	Water	42-47	aquaporin 1 (Colton blood group)	Homo sapiens	61-65
8714353-1	1995	Structural and chemical peculiarities of the Golgi apparatus elements in granular cells of the normal frog urinary epithelium and under vasopressin stimulation of water transport have been studied with different electron microscopic methods: standard chemical fixation, prolonged osmification, freeze-substitution, freeze-fracture, immunocytochemistry, and electron-probe X-ray microanalysis.	Water	163-168	arginine vasopressin	Homo sapiens	136-147
7809170-1	1994	We have measured the oxygen concentration in the body water of murine FSa and NFSa fibrosarcomas using a new method for quantitative oxygen concentration determination deep in the tissues of a living animal.	Water	54-59	RIKEN cDNA 4932438A13 gene	Mus musculus	70-73
7528536-3	1994	A novel protocol has been developed that enables the site-specific (N-terminus) attachment of hydrophobic peptides to a water-soluble carrier protein [bovine pancreatic trypsin inhibitor (BPTI)] using a heterobifunctional crosslinker (SPDP).	Water	120-125	trophoblast Kunitz domain protein 1	Bos taurus	169-186
7634256-3	1994	Angiotensin II and renin also regulate the input of water and salt through an unequivocal dipsogenic effect.	Water	52-57	renin	Homo sapiens	19-24
7527658-8	1994	Also, infrared spectra of the lipid carbonyl stretching region show evidence that MBP limits the accessibility of water molecules to the interfacial part of the lipid bilayer.	Water	114-119	myelin basic protein	Bos taurus	82-85
7898322-5	1994	In adrenalectomized rats given an overnight supplement of dexamethasone in their drinking water, the expression of both vasopressin and VIP mRNA in the SCN was elevated the following morning at ZT6 when compared to adrenalectomised rats kept on 0.9% saline.	Water	90-95	arginine vasopressin	Rattus norvegicus	120-131
7898322-5	1994	In adrenalectomized rats given an overnight supplement of dexamethasone in their drinking water, the expression of both vasopressin and VIP mRNA in the SCN was elevated the following morning at ZT6 when compared to adrenalectomised rats kept on 0.9% saline.	Water	90-95	vasoactive intestinal peptide	Rattus norvegicus	136-139
7999778-7	1994	A correlation was found for both BSA and lysozyme in KAsp, NaGlu, LysHCl, ArgGlu, and LysGlu between the surface tension effect and the observed preferential interactions, indicating that the change in the surface free energy of the protein-containing cavity due to the surface tension increase for water by these amino acid salts contributes dominantly to the observed increase in the chemical potential of the protein by their addition.	Water	299-304	N-acetyl-alpha-glucosaminidase	Homo sapiens	59-64
10319157-1	1994	The water soluble long-chain crosslinker, sulfo-succinimidyl-6-[3"-(2-pyridyldithio)-propionamido]hexanoate (S-LC-SPDP) was used to prepare ricin A chain (RTA) immunotoxins constructed with whole IgG and Fab fragments of the anti-common acute lymphoblastic leukemia antigen (CALLA) monoclonal antibody.	Water	4-9	membrane metalloendopeptidase	Homo sapiens	225-273
10319157-1	1994	The water soluble long-chain crosslinker, sulfo-succinimidyl-6-[3"-(2-pyridyldithio)-propionamido]hexanoate (S-LC-SPDP) was used to prepare ricin A chain (RTA) immunotoxins constructed with whole IgG and Fab fragments of the anti-common acute lymphoblastic leukemia antigen (CALLA) monoclonal antibody.	Water	4-9	membrane metalloendopeptidase	Homo sapiens	275-280
7634256-1	1994	At least theoretically, ACE-inhibitors may influence each of the factors involved in the regulation of salt and water metabolism.	Water	112-117	angiotensin I converting enzyme	Homo sapiens	24-27
7634256-3	1994	Angiotensin II and renin also regulate the input of water and salt through an unequivocal dipsogenic effect.	Water	52-57	angiotensinogen	Homo sapiens	0-14
7808428-2	1994	Because inflammatory cytokines, e.g., interleukin-1 and tumor necrosis factor-alpha, are considered to activate collagenase gene expression through activation of the transcription factor activator protein-1, we examined whether the water-soluble gold compound aurothiomalate (AuTM) influenced collagenase gene expression, using phorbol ester-treated human fibroblasts.	Water	232-237	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	187-206
7699203-6	1994	The state of self-association of apoE as tetramers within this concentration range was confirmed by cross-linking experiments with a water-soluble bifunctional reagent.	Water	133-138	apolipoprotein E	Homo sapiens	33-37
7536292-6	1994	It may correspond to CHIP28, the water channel of the human erythrocyte.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	21-27
7961799-11	1994	Increasing concentrations of A beta lower the surface tension of water up to a critical concentration, above which little further decrease in surface tension is observed.	Water	65-70	amyloid beta precursor protein	Homo sapiens	29-35
7990707-11	1994	ANF and BNP but not CNP act on mTAL to control water excretion.	Water	47-52	natriuretic peptide B	Rattus norvegicus	8-11
7756988-0	1994	The structures of RNase A complexed with 3"-CMP and d(CpA): active site conformation and conserved water molecules.	Water	99-104	carboxypeptidase A1	Homo sapiens	54-57
18407235-3	1994	In addition to this hypocalcemie effect, calcitonin modulates the renal transport of water and several ions other than calcium and acts on the central nervous system to induce analgesia, anorexia, and gastric secretion.	Water	85-90	calcitonin related polypeptide alpha	Homo sapiens	41-51
18407239-3	1994	The genes involved encode proteins that reside at both ends of the cellular vasopressin signaling cascade, namely the vasopressin V(2) receptor and the aquaporin-2 water channel.	Water	164-169	arginine vasopressin	Homo sapiens	76-87
18407239-4	1994	Analysis of naturally occurring mutations in the V(2) receptor and the aquaporin-2 water channel will facilitate the study of structure-function correlates of both proteins, which will lead to substantial progress in elucidating the cellular mechanisms involved in the antidiuretic effect of vasopressin.	Water	83-88	arginine vasopressin	Homo sapiens	292-303
7961799-13	1994	A beta aggregation is also correlated with the formation of a hydrophobic environment that excludes water.	Water	100-105	amyloid beta precursor protein	Homo sapiens	0-6
7526388-9	1994	Injection of the complementary RNA of AQP3 into Xenopus oocytes markedly increased the osmotic water permeability.	Water	95-100	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	38-42
7969474-3	1994	Here we describe the crystal structure of transducin alpha.GDP activated with aluminium fluoride (Gt alpha.GDP.AIF-4.H2O) at 1.7 A, a resolution sufficient to establish the coordination geometry of the bound aluminium fluoride as well as the extensive network of direct and water-mediated interactions that stabilize it.	Water	117-120	itchy E3 ubiquitin protein ligase	Homo sapiens	111-116
7998936-2	1994	Released Cu2+ from the glycated Cu,Zn-SOD probably facilitates a Fenton reaction to convert H2O2 into hydroxy radical, which then participates in the non-specific fragmentation [Ookawara et al.	Water	102-117	superoxide dismutase 1	Homo sapiens	32-41
7998936-14	1994	These results suggest that hydroxy radical is produced through a Fenton reaction by Cu2+ and H2O2 released from the glycated Cu,Zn-SOD, and participates in nuclear DNA cleavage.	Water	27-42	superoxide dismutase 1	Homo sapiens	125-134
7850474-8	1994	CRH mRNA in the PVN was reduced by 27% after food deprivation and by 67% after water deprivation, but simultaneous food and water deprivation caused a significantly smaller reduction similar to that in food deprivation alone.	Water	79-84	corticotropin releasing hormone	Rattus norvegicus	0-3
7969474-3	1994	Here we describe the crystal structure of transducin alpha.GDP activated with aluminium fluoride (Gt alpha.GDP.AIF-4.H2O) at 1.7 A, a resolution sufficient to establish the coordination geometry of the bound aluminium fluoride as well as the extensive network of direct and water-mediated interactions that stabilize it.	Water	274-279	itchy E3 ubiquitin protein ligase	Homo sapiens	111-116
7969474-7	1994	Thus the Gt alpha.GDP.AIF-4.H2O structure provides new insight into the mechanism of GTP hydrolysis.	Water	28-31	itchy E3 ubiquitin protein ligase	Homo sapiens	22-27
7850474-3	1994	Basal plasma vasopressin levels were normal in food deprived rats, but significantly increased in water deprived and simultaneously food and water deprived rats.	Water	98-103	arginine vasopressin	Rattus norvegicus	13-24
7524655-0	1994	Projection structure of the CHIP28 water channel in lipid bilayer membranes at 12-A resolution.	Water	35-40	aquaporin 1 (Colton blood group)	Homo sapiens	28-34
7702968-0	1994	Optimal dose of injection in activation study with O-15 water and PET.	Water	56-61	immunoglobulin kappa variable 2-36 (pseudogene)	Homo sapiens	51-55
7702968-1	1994	In activation studies with the bolus method for O-15 water and PET, the radiotracer concentration may reach the limits of the system in terms of dead time correction and accidental coincidence.	Water	53-58	immunoglobulin kappa variable 2-36 (pseudogene)	Homo sapiens	48-52
7977842-1	1994	Simultaneous administration of the diuretic furosemide (10 mg/kg) and a low dose of the angiotensin-converting enzyme (ACE) inhibitor captopril (5 mg/kg) results in short-latency thirst and sodium appetite (i.e., the rapid ingestion of water and NaCl solution).	Water	236-241	angiotensin I converting enzyme	Rattus norvegicus	119-122
7524655-1	1994	Osmotic water transport across plasma membranes in erythrocytes and several epithelial cell types is facilitated by CHIP28, a water-selective membrane channel protein.	Water	8-13	aquaporin 1 (Colton blood group)	Homo sapiens	116-122
7828353-1	1994	OBJECTIVE: Growth hormone (GH) replacement therapy in hypopituitary adults is associated with sodium and water retention.	Water	105-110	growth hormone 1	Homo sapiens	11-25
7873639-1	1994	The freezing water solutions of serum albumin in presence of additives of several organic compounds have been studied by 1H NMR spectroscopy.	Water	13-18	albumin	Homo sapiens	38-45
7828353-1	1994	OBJECTIVE: Growth hormone (GH) replacement therapy in hypopituitary adults is associated with sodium and water retention.	Water	105-110	growth hormone 1	Homo sapiens	27-29
7824567-3	1994	We report here that microinjections of 5 and 30 ng (286 fmol and 1.71 pmol) of recombinant human IL-1 beta in the ventromedial nucleus of the hypothalamus (VMH) of adult male rats time- and dose-dependently induce anorexia and weight loss in two experimental paradigms: rats allowed free-access to food and water and food-restricted rats trained to press a lever for food on a fixed ratio 10 schedule.	Water	307-312	interleukin 1 beta	Homo sapiens	97-106
7962346-8	1994	These facts support the proposal that adrenomedullary BNP along with ANP may play some role in water and electrolyte homeostasis or act in a paracrine manner to regulate adrenocortical functions.	Water	95-100	natriuretic peptide A	Homo sapiens	69-72
7890899-5	1994	In the excretors, increased free water excretion was associated with suppressed vasopressin levels (below 0.5 pg/ml) and normal renal function.	Water	33-38	arginine vasopressin	Homo sapiens	80-91
7876998-1	1994	We evaluated the dynamic response of renin, aldosterone, and vasopressin to intravenous water loading (20 ml 5% glucose/kg b.w.)	Water	88-93	arginine vasopressin	Homo sapiens	61-72
7876998-12	1994	We conclude that failure to suppress vasopressin activity after central volume expansion may be one of the early mechanisms responsible for water-electrolyte imbalance in liver cirrhosis in children.	Water	140-145	arginine vasopressin	Homo sapiens	37-48
7829988-5	1994	Water deprivation for 24 h increased plasma AVP levels to 7.2 pmol/l and increased Uosm to 2160 mOsmol/kg H2O.	Water	0-5	arginine vasopressin	Rattus norvegicus	44-47
7824567-0	1994	Reduction in food and water intake induced by microinjection of interleukin-1 beta in the ventromedial hypothalamus of the rat.	Water	22-27	interleukin 1 beta	Rattus norvegicus	64-82
7824567-4	1994	IL-1 beta (5 ng) diminished food and water consumption by 45 and 30%, respectively, and decreased body weight for at least 24 h postinjection in rats fed ad lib.	Water	37-42	interleukin 1 beta	Rattus norvegicus	0-9
17020832-1	1994	The conformational equilibrium of a decapeptide renin inhibitor (Renin Inhibitory Peptide (RIP), NH-P-H-P-F-H-F-F-V-Y-K-CO2H) in water, methanol and trifluoroethanol has been investigated.	Water	129-134	renin	Homo sapiens	48-53
7526855-0	1994	Cloning of a novel cDNA homologous to CHIP28 water channel from ocular ciliary epithelium.	Water	45-50	aquaporin 1 (Colton blood group)	Homo sapiens	38-44
7820657-0	1994	Regional suppression by water intake of c-fos expression induced by intraventricular infusions of angiotensin II.	Water	24-29	angiotensinogen	Rattus norvegicus	98-112
7820657-4	1994	Allowing rats to drink water after AII infusions suppressed c-fos expression both AVP- and OXY-stained magnocellular neurons.	Water	23-28	angiotensinogen	Rattus norvegicus	35-38
7820657-10	1994	These results indicate that AVP and OXY-containing neurons in the magnocellular parts of the SON and PVN alter their immediate-early gene response to AII after water intake, and that this does not depend upon oro-pharyngeal factors.	Water	160-165	angiotensinogen	Rattus norvegicus	150-153
7943311-1	1994	Progressive dehydration due to water deprivation and streptozotocin diabetes both produce increased activity of the hypothalamoneurohypophysial system and enhanced vasopressin secretion.	Water	31-36	arginine vasopressin	Rattus norvegicus	164-175
7859070-4	1994	However, the Fos reaction of vasopressin cells in response to either stimulus was greater than that of oxytocin cells in the supraoptic and paraventricular nuclei, and in the perifornical posterior nucleus and nucleus circularis in response to water deprivation.	Water	244-249	arginine vasopressin	Rattus norvegicus	29-40
7947956-5	1994	A close resemblance to the structure of PTH(1-34)amide in water was noted.	Water	58-63	parathyroid hormone	Homo sapiens	40-43
7524358-1	1994	Vasopressin-regulated water permeability of the kidney collecting duct is a key component of the urine concentration machinery.	Water	22-27	arginine vasopressin	Rattus norvegicus	0-11
17020832-1	1994	The conformational equilibrium of a decapeptide renin inhibitor (Renin Inhibitory Peptide (RIP), NH-P-H-P-F-H-F-F-V-Y-K-CO2H) in water, methanol and trifluoroethanol has been investigated.	Water	129-134	renin	Homo sapiens	65-70
7965715-5	1994	When endothelin-1 or phenylephrine was infused into the liver, portal pressure was increased, reaching maximal levels (50 +/- 17 and 46 +/- 7 mm of H2O, respectively) and then decreasing gradually.	Water	148-151	endothelin 1	Rattus norvegicus	5-17
7928185-10	1994	These results suggest that susceptibility to EAU is in some part mediated by the ability of mice to produce TNF.	Water	45-48	tumor necrosis factor	Mus musculus	108-111
7965715-6	1994	Ebselen reduced the maximal increase in portal pressure induced by endothelin-1 (18 +/- 2 mm of H2O) by 64% (P &lt; .05).	Water	96-99	endothelin 1	Rattus norvegicus	67-79
7820634-2	1994	Water intake stimulated by peripheral administration of the beta-adrenergic agonist, isoproterenol is attenuated by naloxone and is thought to be mediated by release of renin and production of ANG II.	Water	0-5	angiotensinogen	Rattus norvegicus	193-199
7530838-1	1994	The aquaporin CHIP, AQP-CHIP, is a 28-kDa integral membrane protein that functions as a water channel in kidney and red blood cells.	Water	88-93	aquaporin 1 (Colton blood group)	Homo sapiens	20-28
7530838-10	1994	Further, this study provides strong evidence that AQP-CHIP is an endothelial cell water channel found within salivary gland tissue which may contribute to water permeability in the capillary beds.	Water	82-87	aquaporin 1 (Colton blood group)	Homo sapiens	50-58
7530838-10	1994	Further, this study provides strong evidence that AQP-CHIP is an endothelial cell water channel found within salivary gland tissue which may contribute to water permeability in the capillary beds.	Water	155-160	aquaporin 1 (Colton blood group)	Homo sapiens	50-58
7531528-3	1994	Unlike in methanol, the melittin-TASP self-aggregates in water.	Water	57-62	LanC like 2	Homo sapiens	33-37
7531528-6	1994	A partition coefficient of 1.5 x 10(9) M-1 was evaluated from changes of the Trp fluorescence spectra of the TASP in water and in the lipid bilayer.	Water	117-122	LanC like 2	Homo sapiens	109-113
7820620-7	1994	Immersion of one hand in water heated at 47 degrees C produced a short-lasting ES2 reduction.	Water	25-30	ess-2 splicing factor homolog	Homo sapiens	79-82
7831501-10	1994	It is concluded that AII, by controlling CSF formation, may influence the water and electrolyte balance in the brain.	Water	74-79	angiotensinogen	Rattus norvegicus	21-24
7522327-0	1994	Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat.	Water	30-35	arginine vasopressin	Rattus norvegicus	58-69
7835893-1	1994	Human microsomal epoxide hydrolase (mEH) is a xenobiotic-metabolizing enzyme that detoxifies reactive epoxides to more water soluble dihydrodiol compounds.	Water	119-124	epoxide hydrolase 1, microsomal	Mus musculus	36-39
8092222-4	1994	RESULTS: Betamethasone plus thyrotropin-releasing hormone significantly increased fetal lung compliance expressed as milliliters of air per gram of wet weight at 40 cm H2O and 5 cm H2O (0.82 +/- 0.13 and 0.35 +/- 0.10 ml/gm wet lung, respectively) versus betamethasone (0.37 +/- 0.02 and 0.07 +/- 0.02), thyrotropin-releasing hormone (0.38 +/- 0.02 and 0.14 +/- 0.03), and control (0.25 +/- 0.03 and 0.09 +/- 0.01) groups.	Water	168-171	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	28-57
8071329-13	1994	In heavy water (D2O), the Ca(2+)-induced formation of CaM.CaN complex as well as the activity of CaN were decreased, indicating a solvent deuterium isotope effect.	Water	9-14	calmodulin 1	Homo sapiens	54-57
7521540-1	1994	The gene aquaporin-1 encodes channel-forming integral protein (CHIP), a member of a large family of water transporters found throughout nature.	Water	100-105	aquaporin 1 (Colton blood group)	Homo sapiens	9-20
7524336-1	1994	The water channel CHIP28 accounts for the high water permeability of proximal tubules and thin descending limbs of Henle; a homologous water channel, WCH-CD, in the apical membrane of collecting duct principal cells, may be the vasopressin-sensitive water channel.	Water	4-9	aquaporin 1 (Colton blood group)	Homo sapiens	18-24
7524336-1	1994	The water channel CHIP28 accounts for the high water permeability of proximal tubules and thin descending limbs of Henle; a homologous water channel, WCH-CD, in the apical membrane of collecting duct principal cells, may be the vasopressin-sensitive water channel.	Water	47-52	aquaporin 1 (Colton blood group)	Homo sapiens	18-24
7524336-1	1994	The water channel CHIP28 accounts for the high water permeability of proximal tubules and thin descending limbs of Henle; a homologous water channel, WCH-CD, in the apical membrane of collecting duct principal cells, may be the vasopressin-sensitive water channel.	Water	47-52	aquaporin 1 (Colton blood group)	Homo sapiens	18-24
7524336-1	1994	The water channel CHIP28 accounts for the high water permeability of proximal tubules and thin descending limbs of Henle; a homologous water channel, WCH-CD, in the apical membrane of collecting duct principal cells, may be the vasopressin-sensitive water channel.	Water	47-52	aquaporin 1 (Colton blood group)	Homo sapiens	18-24
8092222-4	1994	RESULTS: Betamethasone plus thyrotropin-releasing hormone significantly increased fetal lung compliance expressed as milliliters of air per gram of wet weight at 40 cm H2O and 5 cm H2O (0.82 +/- 0.13 and 0.35 +/- 0.10 ml/gm wet lung, respectively) versus betamethasone (0.37 +/- 0.02 and 0.07 +/- 0.02), thyrotropin-releasing hormone (0.38 +/- 0.02 and 0.14 +/- 0.03), and control (0.25 +/- 0.03 and 0.09 +/- 0.01) groups.	Water	181-184	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	28-57
7531521-3	1994	AQP CHIP is localized to the luminal and contraluminal membranes of the proximal tubule and descending thin limb cells, i.e., in tubule segments that exhibit a constitutive high permeability to water that is insensitive to vasopressin.	Water	194-199	aquaporin 1 (Colton blood group)	Homo sapiens	0-8
16349370-5	1994	The model output faithfully represented the profiles of O(2) and NO(3) and rates of nitrification, denitrification, and O(2) consumption as the O(2) concentration in the overlying water was increased from 10 to 600 muM.	Water	180-185	latexin	Homo sapiens	215-218
7531521-5	1994	Its intracellular distribution depends on vasopressin or hydration status of the animal and, thus, may represent the vasopressin-sensitive water channel.	Water	139-144	arginine vasopressin	Homo sapiens	42-53
7531521-5	1994	Its intracellular distribution depends on vasopressin or hydration status of the animal and, thus, may represent the vasopressin-sensitive water channel.	Water	139-144	arginine vasopressin	Homo sapiens	117-128
7521882-3	1994	The red cell water channel-forming integral protein (Aquaporin CHIP) is a homotetramer with only one N-glycosylated subunit, however no CHIP-associated blood group antigens have yet been identified.	Water	13-18	aquaporin 1 (Colton blood group)	Homo sapiens	53-67
7818866-0	1994	Activation of the vasopressin-sensitive water permeability pathway in the toad bladder by N-ethyl maleimide.	Water	40-45	arginine vasopressin	Homo sapiens	18-29
7818866-1	1994	Vasopressin stimulates transepithelial water flow in the toad urinary bladder.	Water	39-44	arginine vasopressin	Homo sapiens	0-11
7818866-8	1994	Our data suggest that NEM stimulates transepithelial water flow by irreversibly activating cellular mechanisms normally triggered by vasopressin, hence causing the insertion of water channels.	Water	53-58	arginine vasopressin	Homo sapiens	133-144
8049250-1	1994	Pancreatic colipase plays an essential role in the intestinal fat digestion by anchoring lipase on lipid/water interfaces in the presence of bile salts.	Water	105-110	pancreatic lipase	Equus caballus	13-19
7940435-1	1994	BACKGROUND: Patients with the sleep apnoea/hypopnoea syndrome have increased salt and water excretion at night which has been reported to be associated with an increase in plasma levels of atrial natriuretic peptide (ANP).	Water	86-91	natriuretic peptide A	Homo sapiens	189-215
7940435-1	1994	BACKGROUND: Patients with the sleep apnoea/hypopnoea syndrome have increased salt and water excretion at night which has been reported to be associated with an increase in plasma levels of atrial natriuretic peptide (ANP).	Water	86-91	natriuretic peptide A	Homo sapiens	217-220
8831270-1	1994	Studies in humans and experimental animal models suggest that volume overload increases and volume underload decreases release of atrial natriuretic peptide (ANP), a hormone intimately linked to water and electrolyte homeostasis.	Water	195-200	natriuretic peptide A	Homo sapiens	130-156
8831270-1	1994	Studies in humans and experimental animal models suggest that volume overload increases and volume underload decreases release of atrial natriuretic peptide (ANP), a hormone intimately linked to water and electrolyte homeostasis.	Water	195-200	natriuretic peptide A	Homo sapiens	158-161
7982096-1	1994	Low and high doses of angiotensin converting enzyme (ACE) inhibitors have been shown either to enhance or suppress, respectively, the water intake of rats induced by acute administration of isoproterenol.	Water	134-139	angiotensin I converting enzyme	Rattus norvegicus	22-51
7982096-1	1994	Low and high doses of angiotensin converting enzyme (ACE) inhibitors have been shown either to enhance or suppress, respectively, the water intake of rats induced by acute administration of isoproterenol.	Water	134-139	angiotensin I converting enzyme	Rattus norvegicus	53-56
7749375-1	1994	In the kidney, renal atrial natriuretic peptide (ANP) is considered to play an important role in water and salt homeostasis.	Water	97-102	natriuretic peptide A	Homo sapiens	21-47
8067465-5	1994	Thus the calculated doses of vasopressin to reduce urine flow and free water clearance, as well as to increase urinary osmolality 50% from their control values, were significantly higher in nonestrous females than in males and estrous females.	Water	71-76	arginine vasopressin	Rattus norvegicus	29-40
7749375-1	1994	In the kidney, renal atrial natriuretic peptide (ANP) is considered to play an important role in water and salt homeostasis.	Water	97-102	natriuretic peptide A	Homo sapiens	49-52
7981272-4	1994	Distribution of the binding energy of water molecules has been found from IRS data about water sorption and isotherms of hydration at different temperatures.	Water	38-43	isoleucyl-tRNA synthetase 1	Homo sapiens	74-77
7529179-1	1994	Aquaporin-CHIP, a 28 kDa channel forming protein already referred to as CHIP28, has been identified as the water channel in red blood cells as well as in mammalian renal tubule cells.	Water	107-112	aquaporin 1 (Colton blood group)	Homo sapiens	0-14
7529179-1	1994	Aquaporin-CHIP, a 28 kDa channel forming protein already referred to as CHIP28, has been identified as the water channel in red blood cells as well as in mammalian renal tubule cells.	Water	107-112	aquaporin 1 (Colton blood group)	Homo sapiens	72-78
7529179-3	1994	The present study investigates the possible presence of CHIP28-like proteins in amphibian urinary bladder, where the presence of water channels has been postulated.	Water	129-134	aquaporin 1 (Colton blood group)	Homo sapiens	56-62
8528362-0	1994	Plasma CRH response to water immersion-restraint stress in rats bearing a hypothalamic knife cut.	Water	23-28	corticotropin releasing hormone	Rattus norvegicus	7-10
8528362-1	1994	We reported earlier that the plasma level of corticotropin-releasing hormone (CRH) remained high 120 min after the onset of such strong sustained stress as ether-laparotomy or water immersion-restraint, which reflected the persistent secretion of CRH from the hypothalamic median eminence (ME).	Water	176-181	corticotropin releasing hormone	Rattus norvegicus	45-76
8528362-1	1994	We reported earlier that the plasma level of corticotropin-releasing hormone (CRH) remained high 120 min after the onset of such strong sustained stress as ether-laparotomy or water immersion-restraint, which reflected the persistent secretion of CRH from the hypothalamic median eminence (ME).	Water	176-181	corticotropin releasing hormone	Rattus norvegicus	78-81
8528362-2	1994	We investigated the change in plasma CRH during water immersion-restraint stress in rats bearing an anterolateral cut around the medial basal hypothalamus (MBH) which cuts the CRH neurons from the PVN to the ME.	Water	48-53	corticotropin releasing hormone	Rattus norvegicus	37-40
7517548-13	1994	AQP3 may function as a water and urea exit mechanism in antidiuresis in collecting duct cells.	Water	23-28	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	0-4
7518522-0	1994	Comparison of the conformation of active and nonactive backbone cyclic analogs of substance P as a tool to elucidate features of the bioactive conformation: NMR and molecular dynamics in DMSO and water.	Water	196-201	tachykinin precursor 1	Homo sapiens	82-93
7518522-1	1994	The conformations of two backbone-cyclized substance P analogs as derived from 1H NMR and molecular dynamics simulations carried out in DMSO and water are described.	Water	145-150	tachykinin precursor 1	Homo sapiens	43-54
8024453-10	1994	Survival was poor in both groups when only tap water was offered to the animals after hepatectomy (31% vs 12%).	Water	47-52	nuclear RNA export factor 1	Rattus norvegicus	43-46
7528593-8	1994	A correlation between the content in CHIP 28 and the relative water permeability among RBC from different vertebrate species was attempted.	Water	62-67	aquaporin 1 (Colton blood group)	Homo sapiens	37-44
20692968-3	1994	Isolated myeloperoxidase (MPO) in conjunction with hydrogen peroxide (H(2)O(2)) activates BP-7,8-diol to (+)-anti-BPDE.	Water	70-75	myeloperoxidase	Homo sapiens	9-24
7517548-5	1994	We named this channel aquaporin 3 (AQP3) for its predominant water permeability.	Water	61-66	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	22-33
7517548-5	1994	We named this channel aquaporin 3 (AQP3) for its predominant water permeability.	Water	61-66	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	35-39
7517548-8	1994	Osmotic water permeability of Xenopus oocytes measured by videomicroscopy was 10-fold higher in oocytes injected with AQP3 transcript than with water-injected oocytes.	Water	8-13	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	118-122
7948589-3	1994	Surface analysis by static secondary ion mass spectroscopy revealed the presence of PEO-PPO at the microsphere surface after cleaning by centrifuging and resuspension in water, and after further cleaning by dialysis.	Water	170-175	protoporphyrinogen oxidase	Homo sapiens	88-91
7981272-4	1994	Distribution of the binding energy of water molecules has been found from IRS data about water sorption and isotherms of hydration at different temperatures.	Water	89-94	isoleucyl-tRNA synthetase 1	Homo sapiens	74-77
8035321-2	1994	The mechanism of kappa agonist-induced water diuresis is unclear but may involve inhibition of vasopressin secretion and/or an adrenomedullary factor.	Water	39-44	arginine vasopressin	Rattus norvegicus	95-106
8054469-3	1994	The effect of increasing concentration of TFE in water on the difference ellipticity at 222 nm was examined and showed that BK may be a mixture of at least two different conformers, one of which largely forms when the TFE concentration is increased beyond 80%.	Water	49-54	kininogen 1	Homo sapiens	124-126
8013090-7	1994	With diminished ADH secretion and normal renal function, a substantial volume of free water is cleared in response to hypotonic stimuli.	Water	86-91	arginine vasopressin	Homo sapiens	16-19
8035321-8	1994	The data suggest that kappa agonists cause a water diuresis by both a central mechanism involving inhibition of vasopressin secretion and a peripheral mechanism involving stimulation of renal alpha-2 receptors.	Water	45-50	arginine vasopressin	Rattus norvegicus	112-123
8072215-4	1994	Vasopressin-regulated water channel in the apical membrane of the collecting duct and water channel in the basolateral side of the membrane were cloned.	Water	22-27	arginine vasopressin	Homo sapiens	0-11
7933842-1	1994	The present study was undertaken to determine whether a non-peptide arginine vasopressin (AVP) antagonist [5-dimethylamino-1-(4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetra hydro-1H- benzazepine] (OPC-31260) improves the impaired water excretion in rats with experimental liver cirrhosis.	Water	230-235	arginine vasopressin	Rattus norvegicus	90-93
24197033-1	1994	The prothrombin time of the normal human pooled plasma was shortened by Aldrich humic acid well water humic substances and lignin at final concentrations ranging from 5 x 10(-3) mg mL(-1) to 5 x 10(-2) mg mL(-1), with a maxmum effect at 1 x 10(-2) mg mL(-1).	Water	96-101	coagulation factor II, thrombin	Homo sapiens	4-15
8177268-1	1994	BACKGROUND: The renin-angiotensin system is a powerful pressor system with a major influence on salt and water homeostasis.	Water	105-110	renin	Homo sapiens	16-21
7525117-1	1994	Alkaline phosphatase (ALP) isoforms can be distinguished from each other by their partition characteristics in aqueous two-phase systems composed of water-soluble polymers, the phases of which are differentially sensitive to the presence of glycan-phosphatidylinositol anchors.	Water	149-154	alkaline phosphatase, placental	Homo sapiens	0-20
7525117-1	1994	Alkaline phosphatase (ALP) isoforms can be distinguished from each other by their partition characteristics in aqueous two-phase systems composed of water-soluble polymers, the phases of which are differentially sensitive to the presence of glycan-phosphatidylinositol anchors.	Water	149-154	alkaline phosphatase, placental	Homo sapiens	22-25
7938947-0	1994	Role of membrane traffic in the water and Na+ responses to vasopressin.	Water	32-37	arginine vasopressin	Homo sapiens	59-70
7922029-5	1994	CONCLUSIONS: Stearate, elaidate and oleate each adopt highly similar U-shaped conformations when they bind to M-FABP within a large interior binding cavity, which also contains 13 ordered water molecules.	Water	188-193	fatty acid binding protein 3	Homo sapiens	110-116
7922526-3	1994	In Long Evans rats, AII-induced water intake and pressor effects were inhibited by EXP 3174 and PD 123319 (although with different time courses).	Water	32-37	angiotensinogen	Rattus norvegicus	20-23
7922526-9	1994	AII-induced water intake, these results cannot be easily reconciled with a simple model of thirst in which AT2-receptors are involved in a final common pathway for drinking.	Water	12-17	angiotensinogen	Rattus norvegicus	0-3
8204630-0	1994	Deamidation of triosephosphate isomerase in reverse micelles: effects of water on catalysis and molecular wear and tear.	Water	73-78	triosephosphate isomerase 1	Homo sapiens	15-40
8204630-4	1994	In order to explore this interaction, triosephosphate isomerase was entrapped in reverse micelles with different water contents that support different catalytic rates.	Water	113-118	triosephosphate isomerase 1	Homo sapiens	38-63
8196772-1	1994	Redox-dependent changes in the position of bound water inside cytochrome c in solution may be important for its function as an electron transfer protein.	Water	49-54	cytochrome c, somatic	Homo sapiens	62-74
8199199-0	1994	Native-like structure and self-association behavior of apolipoprotein A-I in a water/n-propanol solution.	Water	79-84	apolipoprotein A1	Homo sapiens	55-73
8203370-3	1994	Mechanisms by which angiotensin II, hypokalemia, and proteinuria can affect salt and water balances, and the role of angiotensin II as a cause of heavy proteinuria are discussed.	Water	85-90	angiotensinogen	Homo sapiens	20-34
8194694-1	1994	BACKGROUND/AIMS: Interleukin 1 beta (IL-1 beta) is known to regulate intestinal ion and water transport in vitro through prostaglandin release.	Water	88-93	interleukin 1 beta	Rattus norvegicus	17-35
8194694-1	1994	BACKGROUND/AIMS: Interleukin 1 beta (IL-1 beta) is known to regulate intestinal ion and water transport in vitro through prostaglandin release.	Water	88-93	interleukin 1 beta	Rattus norvegicus	37-46
7520397-4	1994	A 60-kDa heat shock protein was induced by pre-treatment with water-immersion stress in the pancreas.	Water	62-67	selenoprotein K	Rattus norvegicus	9-27
8194694-2	1994	This study investigated the effect of IL-1 beta on colonic net water flux in vivo to determine its nature (nerve mediation versus action on the epithelium), the mediators involved, and its relationship with mast cell degranulation.	Water	63-68	interleukin 1 beta	Rattus norvegicus	38-47
7916865-5	1994	Furthermore a significant reduction in the parameter AOX and an improvement of the data H 17 and COD could be achieved at the waste water outlet of the machine and at the waste pipe of the whole kitchen without any reduction of the hygienic demands.	Water	132-137	acyl-CoA oxidase 1	Bos taurus	53-56
8071385-8	1994	The presence of air at the water-carbon interface seems to prevent the surface denaturation of fibrinogen.	Water	27-32	fibrinogen beta chain	Homo sapiens	95-105
7931364-2	1994	This substance is a water-soluble, competitive, irreversible inhibitor of Interleukin-1 beta Converting Enzyme that is inactive against papain and trypsin.	Water	20-25	caspase 1	Homo sapiens	74-110
8196050-5	1994	The catalytic water was clearly observed between the two aspartates which were not perfectly co-planar, and in this structure the active site cleft is more restricted than for either inhibitor bound or ligand-free HIV-1 proteinase.	Water	14-19	endogenous retrovirus group K member 25	Homo sapiens	220-230
8203619-0	1994	Role of endogenous vasopressin in development of gastric ulcer induced by restraint and water immersion.	Water	88-93	arginine vasopressin	Rattus norvegicus	19-30
8185624-4	1994	The percentages of Thy 1.2-(pan T cells), L3T4-(helper T cells) and Lyt2-(cytotoxic T cells) positive cell population were significantly increased in the mice orally administered hot water soluble fraction from wild Panax ginseng as compared to control by 31.2, 17.9 and 30.1 percent, respectively.	Water	183-188	thymus cell antigen 1, theta	Mus musculus	19-26
8062074-7	1994	Before and after surgery, all groups drank equivalent amounts of water in response to s.c. angiotensin II and to s.c. hypertonic saline, indicating the lesions specifically affected salt appetite.	Water	65-70	angiotensinogen	Rattus norvegicus	91-105
7513799-1	1994	Tritium beta radiation (3H beta-radiation) in the form of tritiated water was used to induce mutations at the alcohol dehydrogenase (Adh) locus in male Drosophila melanogaster post-meiotic germ cells.	Water	68-73	Alcohol dehydrogenase	Drosophila melanogaster	110-131
8063672-5	1994	The present study shows that, at thermal steady state during partial immersion in water at 20 degrees C, the convective heat transfer between the blood and the forearm tissue is the major heat source of the tissue and accounts for 85% of the total heat loss to the environment.	Water	82-87	cullin associated and neddylation dissociated 2 (putative)	Homo sapiens	102-103
8063672-7	1994	At thermal steady state during partial immersion in water at 38 degrees C, the blood has the role of a heat sink, carrying away from the limb the heat gained from the environment and, to a lesser extent (25%), the metabolic and conductive heats.	Water	52-57	cullin associated and neddylation dissociated 2 (putative)	Homo sapiens	72-73
8072247-7	1994	Random migration of peritoneal macrophages obtained from rats with urethral obstruction given L-arginine prior to obstruction was significantly lower than that of peritoneal macrophages obtained from similar rats given tap water alone prior to obstruction.	Water	223-228	nuclear RNA export factor 1	Rattus norvegicus	219-222
7935197-6	1994	For model 6711 I-125 seeds at 1 cm in PMMA and WT1, the calculated ratios of dose rate to water to dose rate to water in the solid phantom are 0.893 and 1.038, respectively.	Water	90-95	WT1 transcription factor	Homo sapiens	47-50
8003621-4	1994	The beta-turn forming potential of bradykinin in three vastly different local chemical environments, DMSO, 9:1 dioxane/water, and in the presence of 7.4 mM lyso phosphatidylcholine micelles, was investigated using two-dimensional homonuclear nmr experiments coupled with simulated annealing calculations.	Water	119-124	kininogen 1	Homo sapiens	35-45
7513799-1	1994	Tritium beta radiation (3H beta-radiation) in the form of tritiated water was used to induce mutations at the alcohol dehydrogenase (Adh) locus in male Drosophila melanogaster post-meiotic germ cells.	Water	68-73	Alcohol dehydrogenase	Drosophila melanogaster	133-136
7935197-6	1994	For model 6711 I-125 seeds at 1 cm in PMMA and WT1, the calculated ratios of dose rate to water to dose rate to water in the solid phantom are 0.893 and 1.038, respectively.	Water	112-117	WT1 transcription factor	Homo sapiens	47-50
8184959-1	1994	Centrally released vasopressin plays an important role in the regulation of brain water and electrolyte composition and can affect brain intracellular pH and ATP synthesis in vivo.	Water	82-87	arginine vasopressin	Rattus norvegicus	19-30
8179604-8	1994	A beta(25-35) rapidly quenches the paramagnetism of membrane-bound 12-nitroxyl stearate spin probe deep within the lipid bilayer, but reacts poorly with the 5-nitroxyl isomer whose paramagnetic center is near the lipid/water interface.	Water	219-224	amyloid beta precursor protein	Homo sapiens	0-6
8161522-0	1994	Characterization of acylating and deacylating activities of an extracellular phospholipase A2 in a water-restricted environment.	Water	99-104	phospholipase A2 group IB	Homo sapiens	77-93
8159683-1	1994	Guanylin, a bioactive peptide, has recently been isolated from the intestine; this peptide activates intestinal guanylate cyclase (i.e., guanylate cyclase C) and thus is potentially involved in the regulation of water/electrolyte transport in the gastrointestinal mucosa.	Water	212-217	guanylin	Cavia porcellus	0-8
7520041-7	1994	In addition, functional studies on reconstituted and oocyte-expressed MIP26 excluded the possibility that MIP26 might be a basolateral water channel in the kidney.	Water	135-140	major intrinsic protein of lens fiber	Homo sapiens	106-111
8038386-0	1994	Pulmonary surfactant proteins SP-B and SP-C in spread monolayers at the air-water interface: II.	Water	76-81	surfactant protein C	Homo sapiens	39-43
8038386-2	1994	The interaction of the hydrophobic pulmonary surfactant protein SP-C with dipalmitoylphosphatidylcholine (DPPC), dipalmitoylphosphatidylglycerol (DPPG) and DPPC:DPPG (7:3, mol:mol) in spread monolayers at the air-water interface has been studied.	Water	213-218	surfactant protein C	Homo sapiens	64-68
8038386-7	1994	The results suggest a potential role for SP-C to modify the composition of the monolayer at the air-water interface in the alveoli.	Water	100-105	surfactant protein C	Homo sapiens	41-45
8038387-0	1994	Pulmonary surfactant proteins SP-B and SP-C in spread monolayers at the air-water interface: III.	Water	76-81	surfactant protein C	Homo sapiens	39-43
8038387-2	1994	Spread binary monolayers of surfactant-associated proteins SP-B and SP-C were formed at the air-water interface.	Water	96-101	surfactant protein C	Homo sapiens	68-72
8187317-5	1994	In the diabetes insipidus group, water deprivation caused a twofold increase in plasma renin activities (48 +/- 13.8 ng/l min) while in the control group plasma renin activity levels were not significantly altered (10.2 +/- 1.2 ng/l min).	Water	33-38	renin	Homo sapiens	87-92
8187317-5	1994	In the diabetes insipidus group, water deprivation caused a twofold increase in plasma renin activities (48 +/- 13.8 ng/l min) while in the control group plasma renin activity levels were not significantly altered (10.2 +/- 1.2 ng/l min).	Water	33-38	renin	Homo sapiens	161-166
8187317-10	1994	There is a dissociation between renin and aldosterone in patients with diabetes insipidus under basal conditions, which is exaggerated during water deprivation.	Water	142-147	renin	Homo sapiens	32-37
7520041-1	1994	Two recently cloned water channels, CHIP28 and WCH-CD, are homologous to MIP26, an integral membrane channel-forming protein found in lens fiber plasma membranes.	Water	20-25	aquaporin 1 (Colton blood group)	Homo sapiens	36-42
7520041-1	1994	Two recently cloned water channels, CHIP28 and WCH-CD, are homologous to MIP26, an integral membrane channel-forming protein found in lens fiber plasma membranes.	Water	20-25	major intrinsic protein of lens fiber	Homo sapiens	73-78
8038384-0	1994	Evidence for a bound water molecule next to the retinal Schiff base in bacteriorhodopsin and rhodopsin: a resonance Raman study of the Schiff base hydrogen/deuterium exchange.	Water	21-26	rhodopsin	Homo sapiens	79-88
8038384-9	1994	Remarkably, the water-catalyzed exchange, which has a half-time of 16 +/- 2 ms and which dominates at pH 3.0 and below, is slower than the exchange rate of the Schiff base in rhodopsin and bacteriorhodopsin.	Water	16-21	rhodopsin	Homo sapiens	175-184
8187167-1	1994	Carbonic anhydrase II (CA II), an enzyme catalyzing the interconversion of CO2 and water to HCO3- and protons, has a key role in osteoclastic bone resorption, but little is known of the regulation of CA II gene expression by calcitonin.	Water	83-88	carbonic anhydrase 2	Rattus norvegicus	0-21
8187167-1	1994	Carbonic anhydrase II (CA II), an enzyme catalyzing the interconversion of CO2 and water to HCO3- and protons, has a key role in osteoclastic bone resorption, but little is known of the regulation of CA II gene expression by calcitonin.	Water	83-88	carbonic anhydrase 2	Rattus norvegicus	23-28
8027368-8	1994	Fragments of the p53 gene were successfully amplified up to 408 base pairs in water boiled extracts, up to 647 in Chelex boiled preparates, and up to 984 in proteinase K digested and proteinase K digested-Chelex boiled samples, although with decreased sensitivity in the last case.	Water	78-83	tumor protein p53	Homo sapiens	17-20
8064168-8	1994	Moreover, ANF induced an increase in fractional free-water excretion and a decrease in fractional free-water reabsorption.	Water	53-58	natriuretic peptide A	Homo sapiens	10-13
8064168-8	1994	Moreover, ANF induced an increase in fractional free-water excretion and a decrease in fractional free-water reabsorption.	Water	103-108	natriuretic peptide A	Homo sapiens	10-13
8140421-0	1994	Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine.	Water	27-32	arginine vasopressin	Homo sapiens	57-68
8174620-1	1994	In order to eliminate Pseudomonas (P.) aeruginosa from a contaminated nude mouse colony, the following procedures were carried out: improvement of environmental sanitation using an effective disinfectant against the organism; supply of tap water acidified with hydrochloric acid at pH2.5-3.0; elimination of mice positive in isolation of P. aeruginosa from the nude mouse colony.	Water	240-245	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	236-239
8023324-1	1994	Vasopressin (ADH) increases transepithelial water flow in renal epithelia by a process that involves the insertion of water channels into the apical membrane.	Water	44-49	arginine vasopressin	Homo sapiens	0-11
8019847-0	1994	Water-avoidance stress-induced c-fos expression in the rat brain and stimulation of fecal output: role of corticotropin-releasing factor.	Water	0-5	corticotropin releasing hormone	Rattus norvegicus	106-136
8140421-4	1994	A male patient with an autosomal recessive form of NDI was found to be a compound heterozygote for two mutations in the gene encoding aquaporin-2, a water channel.	Water	149-154	arginine vasopressin receptor 2	Homo sapiens	51-54
8122110-3	1994	A molecular dynamics simulation of acetylcholinesterase in water reveals the transient opening of a short channel, large enough to pass a water molecule, through a thin wall of the active site near tryptophan-84.	Water	59-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-55
7907586-5	1994	PrP 106-126 exhibited a predominantly beta-sheet structure in 200 mM phosphate buffer, pH 5.0, but a combination of beta-sheet and random coil structure in 200 mM phosphate buffer, pH 7.0, or in deionized water.	Water	205-210	prion protein	Homo sapiens	0-3
8145219-0	1994	High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group.	Water	26-31	cholecystokinin B receptor	Homo sapiens	67-71
8145219-0	1994	High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group.	Water	26-31	cholecystokinin B receptor	Homo sapiens	72-88
8122110-3	1994	A molecular dynamics simulation of acetylcholinesterase in water reveals the transient opening of a short channel, large enough to pass a water molecule, through a thin wall of the active site near tryptophan-84.	Water	138-143	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-55
8156731-15	1994	An increased plasma renin activity associated with the lack of blood pressure rise would reinforce sodium and water retention.	Water	110-115	renin	Homo sapiens	20-25
8160789-8	1994	It is suggested that ET-1 at plasma concentrations found in certain pathophysiological conditions in humans may influence renal perfusion and renal sodium and water excretion.	Water	159-164	endothelin 1	Homo sapiens	21-25
8203747-4	1994	The water-insoluble form was reacted with taurine to achieve water solubility and this squaraine-taurine conjugate displayed a very high affinity for bovine serum albumin.	Water	4-9	albumin	Homo sapiens	157-170
8203747-4	1994	The water-insoluble form was reacted with taurine to achieve water solubility and this squaraine-taurine conjugate displayed a very high affinity for bovine serum albumin.	Water	61-66	albumin	Homo sapiens	157-170
8019752-10	1994	Big ET-1 but not ET-1, produced a significant increase in water and sodium excretion.	Water	58-63	endothelin 1	Rattus norvegicus	4-8
8076430-2	1994	Epidermal growth factor is a potent mitogen that causes natriuresis, diuresis and inhibition of arginine vasopressin-induced water reabsorption.	Water	125-130	arginine vasopressin	Homo sapiens	105-116
8205752-14	1994	Finally, by comparing the effects of enalapril and indomethacin in experimental groups with an equivalent degree of KD, evidence is provided in favour of the interaction between renin-angiotensin and prostanoid systems in controlling the glomerular filtration rate and the salt and water handling by renal tubules.	Water	282-287	renin	Homo sapiens	178-183
8133054-8	1994	Because this compound is known to inhibit the SAP-C4BP interaction, this indicated direct binding of SAP to C4BP to be required for inhibition of C4(H2O) degradation.	Water	149-152	complement component 4 binding protein alpha	Homo sapiens	50-54
7851230-2	1994	DeFronzo et al has used the analogy that insulin resistance can be viewed as a large iceberg submerged just below the water.	Water	118-123	insulin	Homo sapiens	41-48
7516776-1	1994	Human microsomal epoxide hydrolase (mEH) is a biotransformation enzyme that metabolizes reactive epoxide intermediates to more water-soluble trans-dihydrodiol derivatives.	Water	127-132	epoxide hydrolase 1, microsomal	Mus musculus	36-39
8133054-9	1994	Even though C4BP, C4(H2O), and SAP form a multimolecular complex in fluid phase, SAP was found to inhibit binding of C4BP to immobilized C4(H2O).	Water	140-143	complement component 4 binding protein alpha	Homo sapiens	117-121
8156731-10	1994	Six months of treatment with recombinant human growth hormone caused significant increases in total body water, erythrocyte sodium content and sodium transmembrane influx.	Water	105-110	growth hormone 1	Homo sapiens	47-61
8156731-12	1994	After 6 months on recombinant human growth hormone total body water showed a significant negative correlation with plasma renin activity.	Water	62-67	growth hormone 1	Homo sapiens	36-50
8156731-12	1994	After 6 months on recombinant human growth hormone total body water showed a significant negative correlation with plasma renin activity.	Water	62-67	renin	Homo sapiens	122-127
8119540-0	1994	Plasma arginine vasopressin response to oral, gastric, and intravenous water load in patients with cirrhosis.	Water	71-76	arginine vasopressin	Homo sapiens	16-27
8005750-2	1994	A beta-turn conformation was identified from the NOE connectivities observed for the peptide in a mixed solvent of water and DMSO, indicating that this is the biologically active conformation of the peptide.	Water	115-120	amyloid beta precursor protein	Homo sapiens	0-6
8011979-6	1994	However, by 15 to 16 wk postnephrectomy, values of glomerular capillary pressure and efferent arteriolar resistance were significantly greater and the glomerular capillary ultrafiltration coefficient was significantly lower in rats drinking tap water than in rats drinking tap water supplemented with L-arginine.	Water	245-250	nuclear RNA export factor 1	Rattus norvegicus	241-244
8011979-6	1994	However, by 15 to 16 wk postnephrectomy, values of glomerular capillary pressure and efferent arteriolar resistance were significantly greater and the glomerular capillary ultrafiltration coefficient was significantly lower in rats drinking tap water than in rats drinking tap water supplemented with L-arginine.	Water	277-282	nuclear RNA export factor 1	Rattus norvegicus	241-244
8027921-1	1994	The water-insoluble aluminium salt of beta-cyclodextrin sulphate (Al.beta-CyD-Sul) was used as a stabilizer and sustained-release carrier for recombinant human basic fibroblast growth factor (bFGF).	Water	4-9	fibroblast growth factor 2	Homo sapiens	160-190
8027921-1	1994	The water-insoluble aluminium salt of beta-cyclodextrin sulphate (Al.beta-CyD-Sul) was used as a stabilizer and sustained-release carrier for recombinant human basic fibroblast growth factor (bFGF).	Water	4-9	fibroblast growth factor 2	Homo sapiens	192-196
8133054-11	1994	Heparin, which is known to inhibit the interaction between SAP and C4BP, was also found to counteract the inhibitory effect of SAP on C4BP binding to C4(H2O).	Water	153-156	complement component 4 binding protein alpha	Homo sapiens	67-71
8133054-11	1994	Heparin, which is known to inhibit the interaction between SAP and C4BP, was also found to counteract the inhibitory effect of SAP on C4BP binding to C4(H2O).	Water	153-156	complement component 4 binding protein alpha	Homo sapiens	134-138
8133054-12	1994	However, the effect of heparin was biphasic because high concentrations of heparin directly inhibited binding of C4(H2O) to C4BP.	Water	116-119	complement component 4 binding protein alpha	Homo sapiens	124-128
8027921-2	1994	An adsorbate of bFGF with Al.beta-CyD-Sul was prepared by incubating the protein with a suspension of Al.beta-CyD-Sul in water.	Water	121-126	fibroblast growth factor 2	Homo sapiens	16-20
8133054-8	1994	Because this compound is known to inhibit the SAP-C4BP interaction, this indicated direct binding of SAP to C4BP to be required for inhibition of C4(H2O) degradation.	Water	149-152	complement component 4 binding protein alpha	Homo sapiens	108-112
8190756-1	1994	Blockade of central angiotensin receptors with the specific antagonist [Leu8]-ANG II abolished water ingestion and water and sodium excretion induced by infusion of angiotensin II (ANGII) into the lateral ventricle (LV) of rats.	Water	95-100	angiotensinogen	Rattus norvegicus	165-179
8171048-0	1994	Intravenous losartan inhibits the increase in plasma luteinizing hormone and water intake produced by intraventricular angiotensin II.	Water	77-82	angiotensinogen	Rattus norvegicus	119-133
8139483-3	1994	In control rats receiving PB in drinking water (0.5 mg/mL), serum insulin and triglyceride levels were diminished without any change in glucose and cholesterol concentrations in the fed state.	Water	41-46	insulin	Homo sapiens	66-73
8208755-5	1994	Alcohol consumption was attenuated and water intake elevated in the groups receiving ANG II and was unaffected by the vehicle injections.	Water	39-44	angiotensinogen	Rattus norvegicus	85-91
8208755-10	1994	DuP753 produced a dose-dependent attenuation in the suppressive effect of ANG II on alcohol intake and antagonized the dipsogenic effect of ANG II on water intake.	Water	150-155	angiotensinogen	Rattus norvegicus	140-146
8202463-4	1994	The water molecule present in the active site close to the copper ion in wild type (WT) SOD is missing in the MD average structure of the Thr-137--&gt;Ile mutant, while this molecule is present in the MD average structures of all the other mutants and of WT SOD.	Water	4-9	superoxide dismutase 1	Homo sapiens	88-91
8202463-4	1994	The water molecule present in the active site close to the copper ion in wild type (WT) SOD is missing in the MD average structure of the Thr-137--&gt;Ile mutant, while this molecule is present in the MD average structures of all the other mutants and of WT SOD.	Water	4-9	superoxide dismutase 1	Homo sapiens	258-261
8119932-8	1994	On incubation of purified LPL with chylomicrons in an ethanol/water mixture, FAEE was formed in the presence of a high concentration of bovine serum albumin.	Water	62-67	lipoprotein lipase	Rattus norvegicus	26-29
7908853-0	1994	Role of adrenergic pathways of the medial preoptic area in ANGII-induced water intake and renal excretion in rats.	Water	73-78	angiotensinogen	Rattus norvegicus	59-64
7908853-1	1994	In this study, we investigated the participation of adrenergic neurotransmission in angiotensin II- (ANGII)-induced water intake and urinary electrolyte excretion by means of injection of the alpha 1-, alpha 2-, and beta-adrenoceptor antagonists and ANGII into the medial preoptic area (MPOA) in rats.	Water	116-121	angiotensinogen	Rattus norvegicus	84-98
8190756-1	1994	Blockade of central angiotensin receptors with the specific antagonist [Leu8]-ANG II abolished water ingestion and water and sodium excretion induced by infusion of angiotensin II (ANGII) into the lateral ventricle (LV) of rats.	Water	95-100	angiotensinogen	Rattus norvegicus	181-186
7908853-1	1994	In this study, we investigated the participation of adrenergic neurotransmission in angiotensin II- (ANGII)-induced water intake and urinary electrolyte excretion by means of injection of the alpha 1-, alpha 2-, and beta-adrenoceptor antagonists and ANGII into the medial preoptic area (MPOA) in rats.	Water	116-121	angiotensinogen	Rattus norvegicus	101-106
7908853-2	1994	Prazosin (an alpha 1-adrenergic antagonist) antagonized the water ingestion, Na+, K+ and urine excretion induced by ANGII, whereas yohimbine (an alpha 2-adrenergic antagonist) enhanced the Na+, K+ and urine excretion induced by ANGII.	Water	60-65	angiotensinogen	Rattus norvegicus	116-121
8190756-1	1994	Blockade of central angiotensin receptors with the specific antagonist [Leu8]-ANG II abolished water ingestion and water and sodium excretion induced by infusion of angiotensin II (ANGII) into the lateral ventricle (LV) of rats.	Water	115-120	angiotensinogen	Rattus norvegicus	165-179
8190756-1	1994	Blockade of central angiotensin receptors with the specific antagonist [Leu8]-ANG II abolished water ingestion and water and sodium excretion induced by infusion of angiotensin II (ANGII) into the lateral ventricle (LV) of rats.	Water	115-120	angiotensinogen	Rattus norvegicus	181-186
8190756-4	1994	When central ANGII infusion was combined with peripheral DOCA, the water intake was similar to that induced by ANGII alone and the ingestion of 3% NaCl was increased, whereas sodium excretion was inhibited.	Water	67-72	angiotensinogen	Rattus norvegicus	13-18
8190756-6	1994	Combined administration of ANGII and DOCA induce significant changes in water and sodium balance.	Water	72-77	angiotensinogen	Rattus norvegicus	27-32
8190756-8	1994	The data support an interaction of central ANGII and DOCA on sodium intake and water and sodium balance.	Water	79-84	angiotensinogen	Rattus norvegicus	43-48
8190778-2	1994	Sexually inert newts injected with prolactin (PRL) and human chorionic gonadotropin (HCG) in combination preferred the water in which newts of the opposite sex had been kept, whereas saline-injected specimens did not.	Water	119-124	prolactin	Homo sapiens	35-44
8177860-16	1994	Finally, CGRP increases electrolyte and water flow in the colon and its bronchoconstrictor effect could be implicated in asthma.	Water	40-45	calcitonin related polypeptide alpha	Homo sapiens	9-13
8190778-4	1994	The water in which PRL plus HCG-treated newts had been kept attracted the opposite sex more intensely than the water in which PRL-, HCG-, or saline-injected newts had been kept.	Water	4-9	prolactin	Homo sapiens	19-22
8293571-6	1994	Recombinant human IL-2 (intravenously for 60 minutes) at 10(6) U per rat (n = 4) elevated lung water content (37 +/- 6%, P &lt; .05), myeloperoxidase activity (162 +/- 49%, P &lt; .05), and serum thromboxane B2 (30 +/- 1 pg/100 microL, P &lt; .01) and had no effect on serum tumor necrosis factor-alpha sCR-1 at 30 mg/kg (n = 5), but not at 10 mg/kg (n = 6), attenuated the elevation of lung water content (18 +/- 2%, P &lt; .05) and myeloperoxidase activity (42 +/- 9%, P &lt; .05) but failed to alter serum thromboxane B2 response to IL-2.	Water	392-397	interleukin 2	Homo sapiens	18-22
8179847-3	1994	Head out of water immersion (HOI) in a thermoneutral bath induces diuresis and natriuresis, an increase in plasma ANF, and reductions in plasma renin activity and aldosterone concentrations.	Water	12-17	natriuretic peptide A	Homo sapiens	114-117
8179847-3	1994	Head out of water immersion (HOI) in a thermoneutral bath induces diuresis and natriuresis, an increase in plasma ANF, and reductions in plasma renin activity and aldosterone concentrations.	Water	12-17	renin	Homo sapiens	144-149
8293571-6	1994	Recombinant human IL-2 (intravenously for 60 minutes) at 10(6) U per rat (n = 4) elevated lung water content (37 +/- 6%, P &lt; .05), myeloperoxidase activity (162 +/- 49%, P &lt; .05), and serum thromboxane B2 (30 +/- 1 pg/100 microL, P &lt; .01) and had no effect on serum tumor necrosis factor-alpha sCR-1 at 30 mg/kg (n = 5), but not at 10 mg/kg (n = 6), attenuated the elevation of lung water content (18 +/- 2%, P &lt; .05) and myeloperoxidase activity (42 +/- 9%, P &lt; .05) but failed to alter serum thromboxane B2 response to IL-2.	Water	95-100	interleukin 2	Homo sapiens	18-22
8157176-0	1994	Murine experimental autoimmune uveoretinitis induced by interphotoreceptor retinoid-binding protein and Klebsiella pneumoniae 03 lipopolysaccharide (K03-LPS): a relation between H-2 haplotype and EAU induction.	Water	196-199	histocompatibility-2, MHC	Mus musculus	178-181
7951559-0	1994	Effects of an acute water load on plasma ANP and AVP, and renal water handling in hypothyroidism: comparison of before and after L-thyroxine treatment.	Water	20-25	natriuretic peptide A	Homo sapiens	41-44
7951559-1	1994	To assess whether atrial natriuretic peptide (ANP) and arginine vasopressin (AVP) participate in impaired water excretion in patients with hypothyroid states (HS), an oral acute water loading (WL) test (20 ml/kg.BW/45 min) was performed before and after L-thyroxine (T4) treatment in 5 hypothyroid patients.	Water	106-111	natriuretic peptide A	Homo sapiens	46-49
8157176-3	1994	Based on the incidence of EAU induction using B10 congenic mice and other strains, the susceptibility to EAU was, at least in part, controlled by the I-Ak haplotype of the H-2 subregion.	Water	26-29	histocompatibility-2, MHC	Mus musculus	172-175
8157176-3	1994	Based on the incidence of EAU induction using B10 congenic mice and other strains, the susceptibility to EAU was, at least in part, controlled by the I-Ak haplotype of the H-2 subregion.	Water	105-108	histocompatibility-2, MHC	Mus musculus	172-175
8134401-1	1994	Subchronic (30 days) exposure of rats to Co(NO3)2 or NiSO4 (20 mg.kg-1) in drinking water caused suppression of the isolated vas deferens contractile responses to exogenous adenosine 5"-triphosphate (ATP), noradrenaline, and l-phenylephrine, shifting the concentration-response curves to the relevant agonist to the right.	Water	84-89	arginine vasopressin	Rattus norvegicus	125-128
8106635-2	1994	Water immersion alone induced a marked, comparable natriuresis (P &lt; 0.001) in both hypertensive groups where a slight reduction of already suppressed renin-angiotensin system and a marked stimulation of atrial natriuretic peptide was also observed (P &lt; 0.03 and P &lt; 0.002, respectively).	Water	0-5	renin	Homo sapiens	153-158
8288866-1	1994	We studied the effect of chronic exposure (6 weeks and 6 months) of mice to drinking (tap) water containing 1.76% (0.06 M) aluminum lactate on some cytochemical properties of the blood-brain barrier (BBB).	Water	91-96	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	86-89
8126382-5	1994	Vasopressin was decreased during the water immersion and increased after the exercise, but plasma renin activity was decreased in these two conditions.	Water	37-42	arginine vasopressin	Homo sapiens	0-11
8126382-6	1994	The hANP concentration was significantly (p &lt; 0.001) increased after the exercise in water and correlated with the urine volume (ml/hour) during the examination.	Water	88-93	natriuretic peptide A	Homo sapiens	4-8
8126930-5	1994	The maximum levels of CNP concentrations were 871 and 554 ng/l in river and faucet water, respectively on May 6, 1992 in Niigata City.	Water	83-88	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	22-25
8126930-6	1994	The concentration of CNP in faucet water was well correlated with that in river water.	Water	35-40	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	21-24
8126930-8	1994	As to the concentrations of CNP in faucet water in Joetsu City, they fluctuated between the levels of 2 and 9 ng/l.	Water	42-47	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	28-31
8126930-9	1994	In the case of CNP-amino concentrations in faucet water, a clear-cut difference was evident between the two cities; 384 ng/l in Niigata and under the quantity limit in Joetsu.	Water	50-55	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	15-18
8146209-2	1994	These studies demonstrate that the effect of NPY on food and water intake are seen after infusion into either the third (3V) or fourth (4V) ventricle and that this is a specific effect, as it was not seen with the deaminated form.	Water	61-66	neuropeptide Y	Rattus norvegicus	45-48
8283058-3	1994	EAU-susceptible B10.A mice treated with a mAb to IFN-gamma developed much more severe EAU than did the controls and had increased delayed hypersensitivity (DH) responses to IRBP.	Water	0-3	interferon gamma	Mus musculus	49-58
8146209-8	1994	Lateral knife cuts virtually abolish the effect of 4V NPY on stimulating water intake.	Water	73-78	neuropeptide Y	Rattus norvegicus	54-57
8146209-9	1994	3V NPY in the presence of NPY has a less clear effect at 1 h, but mildly attenuated the NPY effect on water intake at 2 h in lateral knife cut rats.	Water	102-107	neuropeptide Y	Rattus norvegicus	3-6
8146209-10	1994	Medial knife cuts slightly attenuate the effect of 3V NPY on water intake.	Water	61-66	neuropeptide Y	Rattus norvegicus	54-57
8173956-2	1994	Water intake is stimulated by both central administration of angiotensin II (ANG II) and peripheral administration of a hypertonic saline solution; both responses are reduced by general opioid antagonists.	Water	0-5	angiotensinogen	Rattus norvegicus	61-75
8173956-2	1994	Water intake is stimulated by both central administration of angiotensin II (ANG II) and peripheral administration of a hypertonic saline solution; both responses are reduced by general opioid antagonists.	Water	0-5	angiotensinogen	Rattus norvegicus	77-83
8173956-4	1994	Whereas systemic naltrexone (0.1-2.5 mg/kg, s.c.) reduced water intake induced by either peripheral ANGII (500 micrograms/kg, s.c.) or hypertonic saline (3 ml/kg, 10%), intracerebroventricular (i.c.v.)	Water	58-63	angiotensinogen	Rattus norvegicus	100-105
8283058-11	1994	We conclude that endogenously produced IFN-gamma at the systemic level acts to down-regulate EAU in the mouse and that IFN-gamma-related mechanisms may be involved in conferring resistance to EAU in some mouse genotypes.	Water	93-96	interferon gamma	Mus musculus	39-48
8283058-11	1994	We conclude that endogenously produced IFN-gamma at the systemic level acts to down-regulate EAU in the mouse and that IFN-gamma-related mechanisms may be involved in conferring resistance to EAU in some mouse genotypes.	Water	192-195	interferon gamma	Mus musculus	119-128
8280754-0	1994	Conformational changes of bovine serum albumin upon its adsorption in dodecane-in-water emulsions as revealed by front-face steady-state fluorescence.	Water	82-87	albumin	Homo sapiens	33-46
8003666-2	1994	Thirteen animals received 20% alcohol for 15 weeks ad libitum, and 18 were kept under identical conditions drinking tap water.	Water	120-125	nuclear RNA export factor 1	Rattus norvegicus	116-119
8059586-3	1994	We can conclude that: 1) a remarkable variance in saline and tap water pH is observed.	Water	65-70	nuclear RNA export factor 1	Rattus norvegicus	61-64
8054883-2	1994	In order to precise the characteristics and the specific cellular mechanisms of this reduced hydro-osmotic response we used a sensitive volumetric technique to monitor net water flow and studied the correlation between the antidiuretic hormone (ADH)-induced net water flow and the fine ultrastructural appearance of the urinary bladder epithelium.	Water	262-267	arginine vasopressin	Homo sapiens	223-243
7905713-0	1994	Vasopressin-independent regulation of collecting duct water permeability.	Water	54-59	arginine vasopressin	Rattus norvegicus	0-11
7905713-3	1994	In the present studies, the vasopressin-independent osmotic water permeability was sustained at approximately 300 microns/s for at least 90 min.	Water	60-65	arginine vasopressin	Rattus norvegicus	28-39
7905713-8	1994	These effects were partially blocked by calphostin C, an inhibitor of protein kinase C. These results demonstrate that activation of phosphatidylinositol hydrolysis and/or activation of protein kinase C markedly inhibits osmotic water permeability in isolated perfused IMCD segments, even in the absence of prior stimulation by vasopressin.	Water	229-234	arginine vasopressin	Rattus norvegicus	328-339
8010758-2	1994	Vasopressin stimulates water and cation transport, primarily through a V2/Gs-coupled receptor that activates adenylyl cyclase, which raises cAMP.	Water	23-28	arginine vasopressin	Homo sapiens	0-11
7850414-6	1994	In addition, endothelin stimulates the renin-angiotensin-aldosterone system and atrial natriuretic peptide release and inhibits arginine vasopressin-mediated water reabsorption in the inner medullary collecting duct.	Water	158-163	arginine vasopressin	Homo sapiens	137-148
8055345-3	1994	Male rats were osmotically stimulated by supplying with 2% NaCl solution instead of tap water for 10 days, and then they were rehydrated with tap water.	Water	146-151	nuclear RNA export factor 1	Rattus norvegicus	142-145
7954533-6	1994	Activation of the renin-angiotensin system favours the proximal tubular reabsorption of sodium and water, which may result in dilutional hyponatraemia.	Water	99-104	renin	Homo sapiens	18-23
7875032-2	1994	While vasopressin responsiveness correlates with increased urea/water permeability in some epithelia, oocytes provide a single cell system to determine the coupling relationship.	Water	64-69	arginine vasopressin	Homo sapiens	6-17
7504987-0	1994	The human gene for water channel aquaporin 1 (AQP1) is localized on chromosome 7p15--&gt;p14.	Water	19-24	aquaporin 1 (Colton blood group)	Homo sapiens	33-44
7504987-0	1994	The human gene for water channel aquaporin 1 (AQP1) is localized on chromosome 7p15--&gt;p14.	Water	19-24	aquaporin 1 (Colton blood group)	Homo sapiens	46-50
7795547-5	1994	ANF may also be a long-term regulator of salt and water homeostasis by modulating the renal excretion of sodium.	Water	50-55	natriuretic peptide A	Homo sapiens	0-3
8012894-1	1994	Intracerebroventricular administration of vasoactive intestinal peptide (VIP) disturbed the learning by rats of the location of a platform submerged in a water pool.	Water	154-159	vasoactive intestinal peptide	Rattus norvegicus	42-71
8012894-1	1994	Intracerebroventricular administration of vasoactive intestinal peptide (VIP) disturbed the learning by rats of the location of a platform submerged in a water pool.	Water	154-159	vasoactive intestinal peptide	Rattus norvegicus	73-76
7504987-1	1994	The chromosomal localization of the gene encoding aquaporin 1 (previously called CHIP28), which acts as a water channel in erythrocytes and in the renal proximal tubules and descending limbs of Henle, was determined.	Water	106-111	aquaporin 1 (Colton blood group)	Homo sapiens	50-61
7504987-1	1994	The chromosomal localization of the gene encoding aquaporin 1 (previously called CHIP28), which acts as a water channel in erythrocytes and in the renal proximal tubules and descending limbs of Henle, was determined.	Water	106-111	aquaporin 1 (Colton blood group)	Homo sapiens	81-87
7517730-3	1994	Male Donryu rats were divided into three groups given 0.02% ammonia, 0.1% ammonia or tap water.	Water	89-94	nuclear RNA export factor 1	Rattus norvegicus	85-88
7522207-1	1994	Human growth hormone (GH) mediates longitudinal bone growth and also exerts a variety of other biological effects, e.g. lactogenic, insulin-like, diabetogenic, lipolytic, protein-anabolic and sodium/water-retaining effects.	Water	199-204	growth hormone 1	Homo sapiens	6-20
7875437-6	1994	RESULTS: Results show that C20-sorbin and C7-sorbin decreased the VIP-stimulated net flux of water (inhibition of 40 and 37%, respectively), Na (inhibition of 31 and 30%), C1 (inhibition of 80 and 63%) and HCO3 (inhibition of 15 and 25%).	Water	93-98	vasoactive intestinal peptide	Rattus norvegicus	66-69
7522207-1	1994	Human growth hormone (GH) mediates longitudinal bone growth and also exerts a variety of other biological effects, e.g. lactogenic, insulin-like, diabetogenic, lipolytic, protein-anabolic and sodium/water-retaining effects.	Water	199-204	growth hormone 1	Homo sapiens	22-24
8120182-4	1994	Milk production was correlated positively with DMI and water intake within and across parities.	Water	55-60	Weaning weight-maternal milk	Bos taurus	0-4
8140052-5	1994	This process is accelerated by increasing the temperature and water content of the insulin powder or by performing lyophilization and/or dissolution of insulin in alkaline media.	Water	62-67	insulin	Homo sapiens	83-90
7719662-1	1994	Studies on rats treated for 15 months with ethanol (10%, w/v, solution in drinking water) revealed that the stimulation of hepatic cytochrome P-450 monooxygenases activity was accompanied by enhanced microsomal malondialdehyde formation, a lipid peroxidation index and a decreased level of the antioxidant, alpha-tocopherol.	Water	83-88	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	131-147
7937353-2	1994	In water-deprived rats, a twofold increase in plasma angiotensin(1-7) was associated with similar increases in plasma renin activity, and angiotensin I and angiotensin II levels.	Water	3-8	angiotensinogen	Rattus norvegicus	138-170
8140052-7	1994	The water sorption isotherm for insulin reveals that the extent of aggregation directly correlates with the water uptake by the lyophilized insulin powder, thus pointing to the critical role of protein conformational mobility in the aggregation process.	Water	4-9	insulin	Homo sapiens	32-39
8140052-7	1994	The water sorption isotherm for insulin reveals that the extent of aggregation directly correlates with the water uptake by the lyophilized insulin powder, thus pointing to the critical role of protein conformational mobility in the aggregation process.	Water	4-9	insulin	Homo sapiens	140-147
8140052-7	1994	The water sorption isotherm for insulin reveals that the extent of aggregation directly correlates with the water uptake by the lyophilized insulin powder, thus pointing to the critical role of protein conformational mobility in the aggregation process.	Water	108-113	insulin	Homo sapiens	32-39
8140052-7	1994	The water sorption isotherm for insulin reveals that the extent of aggregation directly correlates with the water uptake by the lyophilized insulin powder, thus pointing to the critical role of protein conformational mobility in the aggregation process.	Water	108-113	insulin	Homo sapiens	140-147
7985515-4	1994	A mixture of acetonitrile and water (80: 20) as mobile phase was used at a flow rate of 1 ml.min-1.	Water	30-35	CD59 molecule (CD59 blood group)	Homo sapiens	93-98
8085219-1	1994	Fluoridated toothpicks (John O. Butler Co.), containing an average of 0.80 mg F as NaF, demonstrated a quick F release in vitro after 1 min immersion in distilled water (0.13 mg; 16%).	Water	163-168	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
24201737-3	1993	This study investigates the toxicity of the water soluble fraction (WSF) of JP-4 using the Standard Aquatic Microcosm (SAM).	Water	44-49	junctophilin 4	Homo sapiens	76-80
8265605-1	1993	Vasopressin (antidiuretic hormone) regulates body water balance by controlling water permeability of the renal collecting ducts.	Water	50-55	arginine vasopressin	Rattus norvegicus	0-11
8265605-3	1993	How this occurs is unknown, but indirect evidence exists for the "shuttle" hypothesis, which states that vasopressin causes exocytic insertion of water channel-laden vesicles from the apical cytosol.	Water	146-151	arginine vasopressin	Rattus norvegicus	105-116
8285268-2	1993	Infusion of vasopressin (3-100 pg.kg-1.min) into conscious, chronically instrumented water-loaded rats resulted in a dose-dependent antidiuresis in both male and female rats.	Water	85-90	arginine vasopressin	Rattus norvegicus	12-23
8285268-4	1993	Thus the effective doses of vasopressin (pg.kg-1.min-1) to decrease urine flow to 30 microliters.min-1.100 g-1 (18 +/- 5 in males; 58 +/- 12 in females), to increase urine osmolality to 600 mosmol/kgH2O (35 +/- 5 in males; 119 +/- 15 in females), and to decrease free water clearance to 30 microliters.min-1.100 g-1 (8 +/- 3 in males; 28 +/- 7 in females) were significantly (P &lt; 0.05) lower in males.	Water	268-273	arginine vasopressin	Rattus norvegicus	28-39
8287854-6	1993	The average ventilation rate at this workload is below 25 l.min-1, with predicted inspiratory mouth pressure equal to, or less than, 20 mm H2O.	Water	139-142	CD59 molecule (CD59 blood group)	Homo sapiens	60-65
24201737-6	1993	The water phase, which contains the water-soluble fraction of JP-4 is then collected.	Water	4-9	junctophilin 4	Homo sapiens	62-66
24201737-6	1993	The water phase, which contains the water-soluble fraction of JP-4 is then collected.	Water	36-41	junctophilin 4	Homo sapiens	62-66
8244709-4	1993	For tritium-in-water analysis, commercial low-level liquid scintillation spectrometers capable of detecting tritium-in-water concentrations as low as 0.65 Bq L-1 for counting times of 500 min are available.	Water	119-124	immunoglobulin kappa variable 1-16	Homo sapiens	158-161
8269922-0	1993	Conformation of thymosin beta 4 in water determined by NMR spectroscopy.	Water	35-40	thymosin beta 4 X-linked	Homo sapiens	16-31
8269922-1	1993	The conformational preferences of a 43-amino-acid G-actin-binding peptide, thymosin beta 4, in water at 1, 4 and 14 degrees C, and at pH 3.0 and 6.5 were studied by NMR.	Water	95-100	thymosin beta 4 X-linked	Homo sapiens	75-90
8269922-2	1993	NMR showed that thymosin beta 4 lacks a uniquely folded conformation in water.	Water	72-77	thymosin beta 4 X-linked	Homo sapiens	16-31
8148042-8	1993	This finding suggests that the increases in plasma and pituitary prolactin levels in larvae at metamorphic climax and in adults that remain in or migrate into water, as reported previously, accompany the increase in prolactin synthesis.	Water	159-164	prolactin	Homo sapiens	65-74
8254021-2	1993	Solute-free water diuretics (aquaretics) by antagonizing hydrosmotic vasopressin receptors (V2) may be useful in treating water-retaining diseases.	Water	12-17	arginine vasopressin	Homo sapiens	69-80
8254021-2	1993	Solute-free water diuretics (aquaretics) by antagonizing hydrosmotic vasopressin receptors (V2) may be useful in treating water-retaining diseases.	Water	122-127	arginine vasopressin	Homo sapiens	69-80
8253872-3	1993	Evidence that bFGF was released from endothelial cells exposed to sustained hydrostatic pressure or compression was provided by the following experimental results: 1) Cells exposed to control (3 mm H2O) pressure displayed intense nuclear and cytoplasmic bFGF staining by immunocytochemical techniques; this staining was absent in cells exposed to 10 cm H2O for 7 days.	Water	198-201	fibroblast growth factor 2	Bos taurus	14-18
8253872-3	1993	Evidence that bFGF was released from endothelial cells exposed to sustained hydrostatic pressure or compression was provided by the following experimental results: 1) Cells exposed to control (3 mm H2O) pressure displayed intense nuclear and cytoplasmic bFGF staining by immunocytochemical techniques; this staining was absent in cells exposed to 10 cm H2O for 7 days.	Water	353-356	fibroblast growth factor 2	Bos taurus	14-18
8253872-4	1993	2) Conditioned medium from endothelial cells exposed to 10 cm H2O for 7 days contained a transferable, growth-promoting activity exhibiting heparin-Sepharose affinity, lability to both heat and freeze/thawing, and neutralization by anti-bovine bFGF.	Water	62-65	fibroblast growth factor 2	Bos taurus	244-248
8136324-3	1993	Maps of the water distribution in the cubic insulin crystal show some well-ordered waters, which are bound to surrounding protein atoms by multiple hydrogen bonds, and an ill-defined solvent structure at a greater distance from the protein surface.	Water	12-17	insulin	Homo sapiens	44-51
8148042-8	1993	This finding suggests that the increases in plasma and pituitary prolactin levels in larvae at metamorphic climax and in adults that remain in or migrate into water, as reported previously, accompany the increase in prolactin synthesis.	Water	159-164	prolactin	Homo sapiens	216-225
8263761-1	1993	We characterized the endothelin (ET) receptor subtype responsible for the inhibition of vasopressin (AVP)-induced increases in osmotic water permeability (Pf) and cAMP accumulation in rat inner medullary collecting ducts (IMCD).	Water	135-140	arginine vasopressin	Rattus norvegicus	88-99
8263611-4	1993	On d 19 of pregnancy, the fructose-fed dams had significantly heavier livers and significantly higher plasma glucose and insulin concentrations than dams consuming tap water.	Water	168-173	nuclear RNA export factor 1	Rattus norvegicus	164-167
8263611-5	1993	Five days after litters were weaned, dams fed fructose had the heaviest body weights, significantly higher plasma glucose concentration compared with the group receiving tap water and significantly higher plasma triglyceride concentration compared with the glucose-fed group.	Water	174-179	nuclear RNA export factor 1	Rattus norvegicus	170-173
8263611-6	1993	Weanlings of the fructose-fed dams had significantly lower plasma glucose concentration but a significantly higher plasma insulin concentration than the weanlings of the group receiving tap water.	Water	190-195	nuclear RNA export factor 1	Rattus norvegicus	186-189
8214739-4	1993	In the first technique, designated the positive pressure technique of bronchial cuff inflation (PPT), the bronchial side of the DLT is pressurized during connection of the tracheal side to a beaker of water.	Water	201-206	tachykinin precursor 1	Homo sapiens	96-99
8218257-0	1993	Nonpolar environment of tryptophans in erythrocyte water channel CHIP28 determined by fluorescence quenching.	Water	51-56	aquaporin 1 (Colton blood group)	Homo sapiens	65-71
8218257-1	1993	CHIP28 is an abundant water-transporting protein in erythrocytes, kidney proximal tubule, and other fluid-transporting tissues.	Water	22-27	aquaporin 1 (Colton blood group)	Homo sapiens	0-6
8218257-3	1993	Functional analysis showed that CHIP28 water permeability was not affected by the polar quenchers iodide and acrylamide nor the nonpolar n-anthroyloxy fatty acids (n-AF).	Water	39-44	aquaporin 1 (Colton blood group)	Homo sapiens	32-38
8238623-2	1993	Intracerebroventricular injection of 6, 12, and 20 ng ET-2 resulted in a significant, dose-related inhibition of water drinking in response to subsequent injection of 100 pmol angiotensin II (ANG II).	Water	113-118	angiotensinogen	Rattus norvegicus	176-190
8238623-2	1993	Intracerebroventricular injection of 6, 12, and 20 ng ET-2 resulted in a significant, dose-related inhibition of water drinking in response to subsequent injection of 100 pmol angiotensin II (ANG II).	Water	113-118	angiotensinogen	Rattus norvegicus	192-198
8139450-5	1993	We report measurements of the magnetic field dependence of 1/T1 of water protons in cross-linked bovine serum albumin (BSA), for partially deuterated solvent and, in order to separate these two contributions, of 1/T1 of deuterons.	Water	67-72	albumin	Homo sapiens	104-117
8309951-10	1993	It is suggested that by inhibiting kininase II, ACE inhibitors extend the duration of action of bradykinin and thereby unmask a potent inhibition of alcohol intake mediated by kinins--an effect that is dissociable from the accompanying stimulation of water intake.	Water	251-256	angiotensin I converting enzyme	Rattus norvegicus	35-46
8309951-10	1993	It is suggested that by inhibiting kininase II, ACE inhibitors extend the duration of action of bradykinin and thereby unmask a potent inhibition of alcohol intake mediated by kinins--an effect that is dissociable from the accompanying stimulation of water intake.	Water	251-256	angiotensin I converting enzyme	Rattus norvegicus	48-51
8293516-7	1993	Entrapment of SOD thus became more efficient due to the enhanced electrostatic attraction between the positively charged membranes and the negatively charged SOD, and/or the electrostatic repulsive interactions between positively charged membranes; the latter interactions induced a thickening of the water layer in MLVs.	Water	301-306	superoxide dismutase 1	Homo sapiens	14-17
8298017-2	1993	First alpha-actinin was incorporated in lipid films at the air/water interface.	Water	63-68	actinin alpha 1	Homo sapiens	6-19
8311944-1	1993	Intracerebroventricular injection of the putative AT2 agonist, p-aminophenylalanine6 angiotensin II (p-NH2Phe6-Ang II), caused dose-dependent increases in intakes of water and NaCl similar to those produced by angiotensin II but requiring more than one thousand times the dose.	Water	166-171	angiotensinogen	Rattus norvegicus	85-99
8311944-1	1993	Intracerebroventricular injection of the putative AT2 agonist, p-aminophenylalanine6 angiotensin II (p-NH2Phe6-Ang II), caused dose-dependent increases in intakes of water and NaCl similar to those produced by angiotensin II but requiring more than one thousand times the dose.	Water	166-171	angiotensinogen	Rattus norvegicus	111-117
7693713-1	1993	Channel forming integral protein of 28 kD (CHIP28) functions as a water channel in erythrocytes, kidney proximal tubule and thin descending limb of Henle.	Water	66-71	aquaporin 1 (Colton blood group)	Homo sapiens	43-49
8112708-1	1993	The renin-angiotensin system (RAS) is known as a system which constricts vessels and enhances renal retention of sodium and water to raise the blood pressure.	Water	124-129	renin	Homo sapiens	4-9
7693713-3	1993	Liposomes reconstituted with HPLC-purified CHIP28 from human erythrocytes had a high osmotic water permeability (Pf0.04 cm/s) that was inhibited by HgCl2.	Water	93-98	aquaporin 1 (Colton blood group)	Homo sapiens	43-49
7693713-10	1993	These results provide a morphological signature for CHIP28 water channels and evidence for a tetrameric assembly of CHIP28 monomers in reconstituted proteoliposomes and cell membranes.	Water	59-64	aquaporin 1 (Colton blood group)	Homo sapiens	52-58
8222514-12	1993	Head-out water immersion suppressed plasma renin activity only in the normal group, whereas the plasma aldosterone level was suppressed in both groups.	Water	9-14	renin	Homo sapiens	43-48
8227349-8	1993	During a 72-h water restriction state, the plasma AVP level increased and V2 receptor mRNA decreased in collecting ducts.	Water	14-19	arginine vasopressin	Rattus norvegicus	50-53
8164338-0	1993	Effects of long-term infusion of synthetic atrial natriuretic factor on hemodynamics and water input-output balance in patients with acute myocardial infarction.	Water	89-94	natriuretic peptide A	Homo sapiens	43-68
8215255-3	1993	Synthetic peptides homologous to A beta form amyloid-like fibrils spontaneously in water or physiological solutions.	Water	83-88	amyloid beta precursor protein	Homo sapiens	33-39
8264158-6	1993	Estimates of renal cortical blood flow by O-15 water in human volunteers were also linearly correlated with those by N-13 ammonia and the Patlak graphical analysis (y = 0.71 + 0.84x, r = 0.86).	Water	47-52	immunoglobulin kappa variable 2-36 (pseudogene)	Homo sapiens	42-46
8413668-5	1993	Antibodies that inhibit the activity of Acanthamoeba myosin-IC in vitro interfere with expulsion of excess water by the contractile vacuole in vivo, leading to overfilling of this organelle and cell lysis.	Water	107-112	myosin IC	Homo sapiens	53-62
8413668-6	1993	Myosin-IC may generate the force required to contract the vacuole and may also be involved in transfer of water to the contractile vacuole during refilling.	Water	106-111	myosin IC	Homo sapiens	0-9
8405432-4	1993	If this were the case, oxygen from solvent H2O would be incorporated into the formyl group of the N10-derivative.	Water	43-46	nuclear receptor subfamily 4 group A member 1	Homo sapiens	98-101
7694481-0	1993	Aquaporin CHIP: the archetypal molecular water channel.	Water	41-46	aquaporin 1 (Colton blood group)	Homo sapiens	0-14
8404613-6	1993	Activation of the magnocellular vasopressinergic system by 60 h of water deprivation increased plasma VP levels from 0.5 +/- 0.1 to 11.8 +/- 0.6 pg/ml, but had no effect on the anterior pituitary CRH receptor concentration in control rats or animals receiving CRH infusion (100 ng/min for 48 h).	Water	67-72	arginine vasopressin	Rattus norvegicus	102-104
8269029-0	1993	Water and ion shifts in mouse intestinal cells following VIP stimulation.	Water	0-5	vasoactive intestinal polypeptide	Mus musculus	57-60
8404613-6	1993	Activation of the magnocellular vasopressinergic system by 60 h of water deprivation increased plasma VP levels from 0.5 +/- 0.1 to 11.8 +/- 0.6 pg/ml, but had no effect on the anterior pituitary CRH receptor concentration in control rats or animals receiving CRH infusion (100 ng/min for 48 h).	Water	67-72	corticotropin releasing hormone	Rattus norvegicus	196-199
8404613-6	1993	Activation of the magnocellular vasopressinergic system by 60 h of water deprivation increased plasma VP levels from 0.5 +/- 0.1 to 11.8 +/- 0.6 pg/ml, but had no effect on the anterior pituitary CRH receptor concentration in control rats or animals receiving CRH infusion (100 ng/min for 48 h).	Water	67-72	corticotropin releasing hormone	Rattus norvegicus	260-263
8404613-7	1993	The CRH receptor concentration was significantly increased in neurointermediate pituitary membranes from water-deprived rats.	Water	105-110	corticotropin releasing hormone	Rattus norvegicus	4-7
7504503-3	1993	Antidiuretic hormone (ADH) stimulation rapidly increases collecting duct epithelial cell Pf by fusion of water channel-containing vesicles (WCV) with their apical membranes.	Water	105-110	arginine vasopressin	Homo sapiens	0-20
8282651-0	1993	Role of vasopressin and atrial natriuretic factor in response to head-out water immersion.	Water	74-79	arginine vasopressin	Homo sapiens	8-19
8406671-1	1993	Arginine vasopressin is a nine-amino acid neuropeptide hormone important in the regulation of water metabolism.	Water	94-99	arginine vasopressin	Rattus norvegicus	9-20
8277781-2	1993	Here we describe a simple and sensitive radioimmunohistochemical assay (RIHA) to quantify a peptide, vasopressin (VP), in discrete brain regions of rats with 3-day water deprivation.	Water	164-169	arginine vasopressin	Rattus norvegicus	101-112
8277781-2	1993	Here we describe a simple and sensitive radioimmunohistochemical assay (RIHA) to quantify a peptide, vasopressin (VP), in discrete brain regions of rats with 3-day water deprivation.	Water	164-169	arginine vasopressin	Rattus norvegicus	114-116
8277781-7	1993	RIHA with aid of a computer-assisted image analysis system revealed that the VP content was significantly reduced in the paraventricular hypothalamic nucleus (PVN) and supraoptic nucleus (SON) of rats with 3-day water deprivation, whereas a parallel in situ hybridization study further demonstrated that VP mRNAs in the PVN and SON were greatly increased.	Water	212-217	arginine vasopressin	Rattus norvegicus	77-79
7504503-3	1993	Antidiuretic hormone (ADH) stimulation rapidly increases collecting duct epithelial cell Pf by fusion of water channel-containing vesicles (WCV) with their apical membranes.	Water	105-110	arginine vasopressin	Homo sapiens	22-25
8216891-1	1993	Experiments replicated the previous finding that rats with high immobilization time in the forced swim test (passive rats) consumed more 15% ethanol solution in a free choice situation with tap water than rats with active behavior (active rats).	Water	194-199	nuclear RNA export factor 1	Rattus norvegicus	190-193
8242374-10	1993	The first experiment showed that rats preferred a corticosterone solution to tap water, developing self-administration in a dose-dependent manner.	Water	81-86	nuclear RNA export factor 1	Rattus norvegicus	77-80
8405302-2	1993	Type II carbonic anhydrase (CAII) in the cytoplasm of the retinal pigment epithelium (RPE) may contribute to the transport of water and solutes across the RPE.	Water	126-131	carbonic anhydrase 2	Oryctolagus cuniculus	28-32
7505413-0	1993	Central administration of senktide, a tachykinin NK-3 agonist, has an antidiuretic action by stimulating AVP release in water-loaded rats.	Water	120-125	arginine vasopressin	Rattus norvegicus	105-108
8214151-1	1993	Intracerebroventricular (icv) infusion of angiotensin II (ANG II) in rats elicits greater water intake under hypotensive, compared with normotensive, conditions.	Water	90-95	angiotensinogen	Rattus norvegicus	42-56
8214031-1	1993	In amphibian bladder, arginine vasopressin (AVP) depolymerizes F-actin in the apical region of the granular cell, promoting fusion of water channel-carrying vesicles with the apical membrane.	Water	134-139	arginine vasopressin	Rattus norvegicus	31-42
8214031-1	1993	In amphibian bladder, arginine vasopressin (AVP) depolymerizes F-actin in the apical region of the granular cell, promoting fusion of water channel-carrying vesicles with the apical membrane.	Water	134-139	arginine vasopressin	Rattus norvegicus	44-47
7692740-1	1993	In toad bladder granular cells, antidiuretic hormone (ADH) stimulates insertion of vesicles containing water channels (WCV), markedly increasing apical membrane osmotic water permeability (Pf).	Water	103-108	arginine vasopressin	Homo sapiens	32-52
7692740-1	1993	In toad bladder granular cells, antidiuretic hormone (ADH) stimulates insertion of vesicles containing water channels (WCV), markedly increasing apical membrane osmotic water permeability (Pf).	Water	103-108	arginine vasopressin	Homo sapiens	54-57
8214151-1	1993	Intracerebroventricular (icv) infusion of angiotensin II (ANG II) in rats elicits greater water intake under hypotensive, compared with normotensive, conditions.	Water	90-95	angiotensinogen	Rattus norvegicus	58-64
8214151-2	1993	The present experiments used sinoaortic baroreceptor-denervated (SAD) rats and sham-operated rats to examine if the modulatory effects of arterial blood pressure on water intake in response to icv ANG II are mediated by arterial baroreceptors.	Water	165-170	angiotensinogen	Rattus norvegicus	197-203
8214151-8	1993	Water intake elicited by icv ANG II was inversely related to changes in MAP.	Water	0-5	angiotensinogen	Rattus norvegicus	29-35
8372830-7	1993	Atrial natriuretic peptide (ANP), which increases sodium and water excretion, has been suspected to participate in fluid retention.	Water	61-66	natriuretic peptide A	Homo sapiens	0-26
8372830-7	1993	Atrial natriuretic peptide (ANP), which increases sodium and water excretion, has been suspected to participate in fluid retention.	Water	61-66	natriuretic peptide A	Homo sapiens	28-31
8214151-9	1993	Specifically, rats drank more water in response to icv ANG II when MAP was reduced by minoxidil but drank less water when MAP was elevated by phenylephrine.	Water	30-35	angiotensinogen	Rattus norvegicus	55-61
8241386-5	1993	Our interpretation is that the cytochrome c-cytochrome b5 complex excludes water.	Water	75-80	cytochrome c, somatic	Homo sapiens	31-43
8241408-12	1993	In particular, the amount of water affects the membrane fluidity, monitored by R perpendicular for CSL, solely by the structural changes it induces in the membrane for the compositions studied.	Water	29-34	chorionic somatomammotropin hormone like 1	Homo sapiens	99-102
8262701-5	1993	However, at similar lactate levels, heart rate during rowing on the water was approximately 10 beats.min-1 higher than during the ergometer multistage step test, due to the different duration of exercise.	Water	68-73	CD59 molecule (CD59 blood group)	Homo sapiens	101-106
8401176-6	1993	The cytolytic activity of faecal water and intestinal alkaline phosphatase activity in faecal water were not affected by supplemental calcium phosphate.	Water	94-99	alkaline phosphatase, intestinal	Homo sapiens	43-74
8105791-8	1993	Angiotensin II releases vasopressin; this could explain water intoxication, which occurs later in the syndrome.	Water	56-61	angiotensinogen	Homo sapiens	0-14
8226515-4	1993	Fiber bundles from rat diaphragm were incubated with exogenous catalase (an antioxidant enzyme that dehydrates hydrogen peroxide to molecular oxygen and water) to decrease the tissue concentration of reactive oxygen intermediates.	Water	153-158	catalase	Rattus norvegicus	63-71
8354920-3	1993	Water samples from the indoor hot tub were culture-negative for legionellae using standard techniques, coculture with amebae, and intraperitoneal inoculation of guinea pigs.	Water	0-5	tubby protein homolog	Cavia porcellus	34-37
8105791-8	1993	Angiotensin II releases vasopressin; this could explain water intoxication, which occurs later in the syndrome.	Water	56-61	arginine vasopressin	Homo sapiens	24-35
8284259-0	1993	Influence of chronic intracerebroventricular infusion of vasoactive intestinal peptide (VIP) on memory processes in Morris water pool test in the rat.	Water	123-128	vasoactive intestinal peptide	Rattus norvegicus	57-86
8371984-8	1993	Model building of Co(II) binding to guanine N7 in B-DNA indicates that the coordinated waters in the axial positions would have a van der Waals clash with the neighboring base on the 5" side.	Water	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
7690183-3	1993	The classical baroceptor, neurogenic, and macula densa mechanisms regulate renin expression at the cellular level by Ca2+, adenosine 3",5"-cyclic monophosphate (cAMP), and chemiosmotic forces (K+, Cl-, and water flux coupled to H+ movement).	Water	206-211	renin	Homo sapiens	75-80
8347590-2	1993	Threonine-199 is a hydrogen bond acceptor for the zinc-bound water, and Phe-198 forms part of the hydrophobic side of the active-site cavity of carbonic anhydrase III.	Water	61-66	carbonic anhydrase 3	Homo sapiens	144-166
8396343-0	1993	Kinetic model of water and urea permeability regulation by vasopressin in collecting duct.	Water	17-22	arginine vasopressin	Homo sapiens	59-70
8396343-1	1993	We present a mathematical model describing the kinetics of water-channel and urea-carrier regulation by vasopressin in the apical membrane of collecting duct cells.	Water	59-64	arginine vasopressin	Homo sapiens	104-115
8368402-5	1993	During maximal water diuresis, plasma vasopressin concentrations were reduced to unquantifiable levels in all subjects.	Water	15-20	arginine vasopressin	Homo sapiens	38-49
8360301-2	1993	A 1-1 sample of water was preconcentrated by passage through a 500-mg C18 solid phase extraction column.	Water	16-21	Bardet-Biedl syndrome 9	Homo sapiens	70-73
8403781-10	1993	Using the servo-control technique, the expected action of 1-desamino-8-D-arginine vasopressin on renal water handling was demonstrated, but the natriuretic effect reported by some workers was not evident.	Water	103-108	arginine vasopressin	Rattus norvegicus	82-93
8228733-2	1993	The PRL-like bioactivity in the water-soluble fraction of rat milk was high and exceeded its immunoreactivity 5.8-, 4.0- and 2.1-fold, on days 2, 12 and 22 of lactation respectively.	Water	32-37	prolactin	Rattus norvegicus	4-7
8393637-5	1993	We hypothesized that under these circumstances, ANP improves pulmonary gas exchange by attenuating the transvascular permeation of plasma (water).	Water	139-144	natriuretic peptide A	Homo sapiens	48-51
8226450-8	1993	Free water clearance (P = 0.05) but not sodium excretion (P = NS) increased during continuous ANP infusion.	Water	5-10	natriuretic peptide A	Homo sapiens	94-97
8346245-2	1993	The aquaporin CHIP (channel-forming integral membrane protein of 28 kDa), a molecular water channel, is abundant in erythrocytes and water-permeable segments of the nephron.	Water	86-91	aquaporin 1 (Colton blood group)	Homo sapiens	20-71
8346245-2	1993	The aquaporin CHIP (channel-forming integral membrane protein of 28 kDa), a molecular water channel, is abundant in erythrocytes and water-permeable segments of the nephron.	Water	133-138	aquaporin 1 (Colton blood group)	Homo sapiens	20-71
8340403-2	1993	Aquaporin-CHIP is the first known molecular water channel.	Water	44-49	aquaporin 1 (Colton blood group)	Homo sapiens	0-14
8393623-0	1993	Dual actions of vasopressin and oxytocin in regulation of water permeability in terminal collecting duct.	Water	58-63	arginine vasopressin	Rattus norvegicus	16-27
8338170-1	1993	Angiotensin II is known to regulate motility and ion and water absorption in the intestine.	Water	57-62	angiotensinogen	Rattus norvegicus	0-14
8393341-1	1993	1H NMR chemical shift assignments for neuropeptide K (NPK) and neurokinin A (NKA) have been determined at 600 MHz in 28% trifluoroethanol/water solution.	Water	138-143	tachykinin precursor 1	Homo sapiens	38-52
8393341-1	1993	1H NMR chemical shift assignments for neuropeptide K (NPK) and neurokinin A (NKA) have been determined at 600 MHz in 28% trifluoroethanol/water solution.	Water	138-143	tachykinin precursor 1	Homo sapiens	54-57
8393341-1	1993	1H NMR chemical shift assignments for neuropeptide K (NPK) and neurokinin A (NKA) have been determined at 600 MHz in 28% trifluoroethanol/water solution.	Water	138-143	tachykinin precursor 1	Homo sapiens	63-75
8393341-1	1993	1H NMR chemical shift assignments for neuropeptide K (NPK) and neurokinin A (NKA) have been determined at 600 MHz in 28% trifluoroethanol/water solution.	Water	138-143	tachykinin precursor 1	Homo sapiens	77-80
8393341-8	1993	A comparison of the tail region of NPK with the related peptide homologue, neurokinin A, in the same solvent system, indicates that both show increasing order when trifluoroethanol is titrated into water solution, with the appearance of sequential NOEs between backbone amide protons.	Water	198-203	tachykinin precursor 1	Homo sapiens	35-38
8393341-8	1993	A comparison of the tail region of NPK with the related peptide homologue, neurokinin A, in the same solvent system, indicates that both show increasing order when trifluoroethanol is titrated into water solution, with the appearance of sequential NOEs between backbone amide protons.	Water	198-203	tachykinin precursor 1	Homo sapiens	75-87
8393623-7	1993	The oxytocin/vasopressin-receptor antagonist [des-glycinamide9,d(CH2)5(1),O-Me-Tyr2,Thr4,Orn8]vasot ocin, which almost completely blocks vasopressin-induced calcium mobilization, also blocked the ability of 10 nM vasopressin to inhibit osmotic water permeability relative to that found with 0.1 nM vasopressin.	Water	244-249	arginine vasopressin	Rattus norvegicus	13-24
8393623-9	1993	1) Oxytocin, like vasopressin, has dual effects on osmotic water permeability, increasing it at subnanomolar concentrations and inhibiting it at suprananomolar concentrations.	Water	59-64	arginine vasopressin	Rattus norvegicus	18-29
8393623-2	1993	Vasopressin and oxytocin were found to have both stimulatory effects (at 0.1 nM) and inhibitory effects (at 10 nM) on osmotic water permeability.	Water	126-131	arginine vasopressin	Rattus norvegicus	0-11
8323965-9	1993	While alpha-helix was the main secondary structure of SP-C in ACN/water mixtures--around 50%--, it had almost exclusively beta-structure when dissolved in 70% TFE.	Water	66-71	surfactant protein C	Homo sapiens	54-58
8393623-10	1993	2) Oxytocin, like vasopressin, can increase cAMP production, perhaps accounting for the increase in water permeability.	Water	100-105	arginine vasopressin	Rattus norvegicus	18-29
7859027-7	1993	Second is the elucidation of several important protein structures via complementary DNA cloning, including the arginine vasopressin V1 and V2 receptors, several organic osmolyte transporters, and the CHIP28 water channel.	Water	207-212	aquaporin 1 (Colton blood group)	Homo sapiens	200-206
7689863-3	1993	The variation of emission parameters with micellar water content was interpreted to suggest that while the tryptophan in alpha-MSH lies in close vicinity of the water-AOT molecular interface, that in delta-MSH is solubilized in the central water pool.	Water	51-56	proopiomelanocortin	Homo sapiens	121-130
7689863-3	1993	The variation of emission parameters with micellar water content was interpreted to suggest that while the tryptophan in alpha-MSH lies in close vicinity of the water-AOT molecular interface, that in delta-MSH is solubilized in the central water pool.	Water	51-56	proopiomelanocortin	Homo sapiens	127-130
7689863-3	1993	The variation of emission parameters with micellar water content was interpreted to suggest that while the tryptophan in alpha-MSH lies in close vicinity of the water-AOT molecular interface, that in delta-MSH is solubilized in the central water pool.	Water	161-166	proopiomelanocortin	Homo sapiens	121-130
7689863-3	1993	The variation of emission parameters with micellar water content was interpreted to suggest that while the tryptophan in alpha-MSH lies in close vicinity of the water-AOT molecular interface, that in delta-MSH is solubilized in the central water pool.	Water	161-166	proopiomelanocortin	Homo sapiens	127-130
7689863-3	1993	The variation of emission parameters with micellar water content was interpreted to suggest that while the tryptophan in alpha-MSH lies in close vicinity of the water-AOT molecular interface, that in delta-MSH is solubilized in the central water pool.	Water	161-166	proopiomelanocortin	Homo sapiens	121-130
7689863-3	1993	The variation of emission parameters with micellar water content was interpreted to suggest that while the tryptophan in alpha-MSH lies in close vicinity of the water-AOT molecular interface, that in delta-MSH is solubilized in the central water pool.	Water	161-166	proopiomelanocortin	Homo sapiens	127-130
8395894-1	1993	The dependence on temperature of the heat capacity of cytochrome c has been measured in the range 4-40 K at various water content.	Water	116-121	cytochrome c, somatic	Homo sapiens	54-66
24202475-4	1993	Eel ANP inhibited water and Na(+) absorption by the intestine of SW eels.	Water	18-23	natriuretic peptide A	Homo sapiens	4-7
8376293-2	1993	Overdrinking was obtained by presenting tap water and sweet water to the rats.	Water	44-49	nuclear RNA export factor 1	Rattus norvegicus	40-43
8504098-0	1993	Influence of amino acid replacement at position 198 on catalytic properties of zinc-bound water in human carbonic anhydrase III.	Water	90-95	carbonic anhydrase 3	Homo sapiens	105-127
8402539-1	1993	Changes in the cytoskeleton of granular cells of the frog urinary bladder under conditions of low and vasopressin-induced water permeability were investigated.	Water	122-127	arginine vasopressin	Homo sapiens	102-113
8396270-9	1993	As well, change in osmolality and/or angiotensin II level, associated with alterations in water and electrolyte balance, act as stimuli to ventilation and interact with chemical control.	Water	90-95	angiotensinogen	Homo sapiens	37-51
8507633-2	1993	For hexokinase both the equilibrium dissociation constant and the kinetic Michaelis-Menten constant for glucose vary linearly, and to the same extent, with the activity of water in the protein medium, as adjusted with large molecular weight (&gt; 2000) osmolytes.	Water	172-177	hexokinase 1	Homo sapiens	4-14
8400617-7	1993	Thus, the well-known tendency of this region of the GRF peptide to form alpha-helix in isotropic mixed-solvent systems (e.g., methanol/water, trifluoroethanol (TFE)/water) is seen also in SDS/aqueous systems.	Water	135-140	growth hormone releasing hormone	Homo sapiens	52-55
8400617-7	1993	Thus, the well-known tendency of this region of the GRF peptide to form alpha-helix in isotropic mixed-solvent systems (e.g., methanol/water, trifluoroethanol (TFE)/water) is seen also in SDS/aqueous systems.	Water	165-170	growth hormone releasing hormone	Homo sapiens	52-55
8328798-3	1993	Attempts to use highly competent PCB-cometabolizing strains in the environment in the absence of biphenyl have not been successful, while the addition of biphenyl is limited by its human toxicity and low water solubility.	Water	204-209	pyruvate carboxylase	Homo sapiens	33-36
8328798-7	1993	The resulting PCB-degrading plasmids were transferred to the FAV host Pseudomonas paucimobilis 1IGP4, which utilizes the nontoxic, water-soluble, nonionic surfactant Igepal CO-720 as a selective growth substrate.	Water	131-136	pyruvate carboxylase	Homo sapiens	14-17
8326825-3	1993	In mammals, MCH modulates ACTH release in vivo and participates as a neuromediator in the control of complex behaviors such as water and food intake.	Water	127-132	pro-melanin concentrating hormone	Homo sapiens	12-15
8508761-0	1993	The vacuolar membrane protein gamma-TIP creates water specific channels in Xenopus oocytes.	Water	48-53	gamma tonoplast intrinsic protein	Arabidopsis thaliana	30-39
8508761-3	1993	gamma-TIP increased the osmotic water permeability of oocytes 6- to 8-fold, to values in the range 1-1.5 x 10(-2) cm/s.	Water	32-37	gamma tonoplast intrinsic protein	Arabidopsis thaliana	0-9
8508761-4	1993	Similar results were obtained with the homologous human erythrocyte protein CHIP28, recently identified as the erythrocyte water channel.	Water	123-128	aquaporin 1 (Colton blood group)	Homo sapiens	76-82
8504772-1	1993	Physiological and ligand binding studies have shown that Angiotensin II (AII) exerts various functions along different segments of the nephron, via the type-1 receptor (AT1R), resulting in the control of glomerular filtration rate (GFR) and water and salt homeostasis.	Water	241-246	angiotensinogen	Rattus norvegicus	57-71
8504772-1	1993	Physiological and ligand binding studies have shown that Angiotensin II (AII) exerts various functions along different segments of the nephron, via the type-1 receptor (AT1R), resulting in the control of glomerular filtration rate (GFR) and water and salt homeostasis.	Water	241-246	angiotensinogen	Rattus norvegicus	73-76
8508761-7	1993	Voltage clamp experiments provided evidence showing that gamma-TIP induced no electrogenic ion transport in oocytes, especially during osmotic challenge that resulted in massive transport of water.	Water	191-196	gamma tonoplast intrinsic protein	Arabidopsis thaliana	57-66
8508761-8	1993	These results allow us to conclude that the various protein members of the MIP family have unique and specific transport functions and that the plant protein gamma-TIP likely functions as a water specific channel in the vacuolar membrane.	Water	190-195	gamma tonoplast intrinsic protein	Arabidopsis thaliana	158-167
8346313-7	1993	CCK injections also reduced water intake, but there was no interaction between estradiol and CCK on drinking.	Water	28-33	cholecystokinin	Homo sapiens	0-3
8349411-7	1993	SP-4 behaves as an amphiphilic alpha-helical peptide at the air-water interface and bound to siliconized quartz slides.	Water	64-69	transcription factor Sp4	Oryctolagus cuniculus	0-4
7683841-1	1993	The present study was undertaken to examine vasopressin gene expression in response to a normal versus hypertonic sodium chloride (506 mOsm/kg H2O) intake for 7 days in Sprague-Dawley rats.	Water	143-146	arginine vasopressin	Rattus norvegicus	44-55
8397430-7	1993	Whereas the adaptation to brackish water decreased the immunoreactivity to anti-ACTH serum on the MSH cells, the volume and the nuclear area of these cells increased although without statistical significance.	Water	35-40	proopiomelanocortin	Homo sapiens	80-84
8388718-3	1993	Similarly, the increase in the surface pressure of sphingosine/eggPA monolayers on an air/water interface due to the membrane penetration of either cyt c or Adr was progressively reduced by increasing the content of sphingosine in the monolayers.	Water	90-95	cytochrome c, somatic	Homo sapiens	148-153
8496923-4	1993	These water-soluble cyclopeptides behave as time-dependent inhibitors of bovine trypsin and human urokinase (u-PA) but have no effect on tissue plasminogen activator (t-PA) and no or poor effect on plasmin and thrombin.	Water	6-11	plasminogen activator, urokinase	Homo sapiens	109-113
8496923-4	1993	These water-soluble cyclopeptides behave as time-dependent inhibitors of bovine trypsin and human urokinase (u-PA) but have no effect on tissue plasminogen activator (t-PA) and no or poor effect on plasmin and thrombin.	Water	6-11	coagulation factor II, thrombin	Homo sapiens	210-218
8496918-0	1993	Orally active water-soluble N,O-acyl transfer products of a beta,gamma-bishydroxyl amide containing renin inhibitor.	Water	14-19	renin	Homo sapiens	100-105
8496330-8	1993	These facts support the proposal that extraatrial (medullary) ANP synthesis might act in a paracrine or endocrine manner to regulate water and electrolyte homeostasis.	Water	133-138	natriuretic peptide A	Homo sapiens	62-65
8498571-3	1993	Thus we hypothesized that bradykinin would also increase transcapillary water flux.	Water	72-77	kininogen 1	Homo sapiens	26-36
8393713-1	1993	The conformation of two agonist-antagonist pairs of bradykinin (Arg1-Pro2-Pro2-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9) analogues were studied in CD3OH/H2O solution by 1H-nmr techniques.	Water	142-145	kininogen 1	Homo sapiens	52-62
7688055-0	1993	Substance P injected into the hypothalamic supraoptic nucleus causes antidiuresis through the release of arginine-vasopressin in water-loaded and ethanol-anesthetized rats.	Water	129-134	arginine vasopressin	Rattus norvegicus	105-125
8340928-3	1993	Washing with SO4-Ringer caused a several-fold increase in net water flow (Jw) and osmotic permeability coefficient (Pf) that was reversed by re-exposure to Cl- or NO3-Ringer and mimicked by gluconate-Ringer.	Water	62-67	NBL1, DAN family BMP antagonist	Homo sapiens	163-166
7683104-3	1993	Twelve NMRI male mice were given lead chloride in the drinking water and 12 male mice received tap water without lead chloride.	Water	99-104	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	95-98
8366814-6	1993	Purified phenol-water LPS (2.5 micrograms) produced Arthus reactivity which could be confused with DTH.	Water	16-21	toll-like receptor 4	Mus musculus	22-25
8316042-1	1993	Most saturated diacyl phosphatidylcholines C(X):C(Y)PC (saturated 1,2-diacyl-sn-glycero-3-phosphocholine with X carbons in the sn-1 acyl chain and Y carbons in the sn-2 acyl chain), in excess water, can self-assemble into lamellae which, upon heating, may undergo multiple thermotropic phase transitions at well-defined, discrete temperatures.	Water	192-197	solute carrier family 38 member 3	Homo sapiens	127-131
8327648-9	1993	Insulin-mediated modulation of capillary permeability to water and electrolytes may also be involved.	Water	57-62	insulin	Homo sapiens	0-7
8465202-4	1993	Measurements of peroxide photoformation rates in authentic atmospheric water samples demonstrate that aqueous-phase photochemical reactions are a significant, and in some cases dominant, source of hydrogen peroxide to cloud and fog drops.	Water	71-76	zinc finger protein, FOG family member 1	Homo sapiens	228-231
8338615-3	1993	The transfer of the expression plasmid of human insulin pSW3 by natural transformation and by transduction with phage P1 was investigated in laboratory media and in surface water samples.	Water	173-178	insulin	Homo sapiens	48-55
8475372-0	1993	Determination of phenoxyacid herbicides in drinking water at the ppt-level by liquid chromatography and on-line selective preconcentration.	Water	52-57	tachykinin precursor 1	Homo sapiens	65-68
8348675-6	1993	1023, 365-379] has shown that PLA2 hydrolysis of pure phospholipid monolayers results in formation of large PLA2 domains at the air-water interface.	Water	132-137	phospholipase A2 group IB	Homo sapiens	30-34
17793535-1	1993	When samples of rain and fog water were exposed to ultraviolet and visible light, reactive transients such as hydrogen peroxide were formed and dissolved organic matter and sulfur dioxide were depleted.	Water	29-34	zinc finger protein, FOG family member 1	Homo sapiens	25-28
8476094-1	1993	We examined whether the generation of tumor necrosis factor (TNF-alpha) after lipopolysaccharide (LPS) challenge contributes to increases in lung vascular permeability and water content.	Water	172-177	tumor necrosis factor	Homo sapiens	38-59
8476094-1	1993	We examined whether the generation of tumor necrosis factor (TNF-alpha) after lipopolysaccharide (LPS) challenge contributes to increases in lung vascular permeability and water content.	Water	172-177	tumor necrosis factor	Homo sapiens	61-70
8348675-6	1993	1023, 365-379] has shown that PLA2 hydrolysis of pure phospholipid monolayers results in formation of large PLA2 domains at the air-water interface.	Water	132-137	phospholipase A2 group IB	Homo sapiens	108-112
8097684-4	1993	Somatostatin had a biphasic effect on basal collecting duct diffusional water permeability with 10(-9) mol/l somatostatin producing a 14% reduction in permeability, whereas concentrations of 10(-6) and 10(-5) mol/l significantly increased basal water permeability by 13% and 22%, respectively.	Water	245-250	somatostatin	Rattus norvegicus	0-12
8097684-0	1993	Somatostatin as a modulator of distal nephron water permeability.	Water	46-51	somatostatin	Rattus norvegicus	0-12
8097684-4	1993	Somatostatin had a biphasic effect on basal collecting duct diffusional water permeability with 10(-9) mol/l somatostatin producing a 14% reduction in permeability, whereas concentrations of 10(-6) and 10(-5) mol/l significantly increased basal water permeability by 13% and 22%, respectively.	Water	72-77	somatostatin	Rattus norvegicus	0-12
8097684-5	1993	Somatostatin (10(-9) mol/l) also inhibited the increase in water permeability produced by arginine vasopressin, although this inhibitory effect was reduced by a 10-fold increase in arginine vasopressin concentration (5 ng/ml).	Water	59-64	somatostatin	Rattus norvegicus	0-12
8097684-5	1993	Somatostatin (10(-9) mol/l) also inhibited the increase in water permeability produced by arginine vasopressin, although this inhibitory effect was reduced by a 10-fold increase in arginine vasopressin concentration (5 ng/ml).	Water	59-64	arginine vasopressin	Rattus norvegicus	99-110
8097684-7	1993	In the anaesthetized water-diuretic rat, low dose somatostatin (60 micrograms/h) increased free water clearance by 23% (P &lt; 0.01), whereas increasing the somatostatin concentration (600 micrograms/h) produced a transitory 40% fall in free water clearance (P &lt; 0.01).	Water	21-26	somatostatin	Rattus norvegicus	50-62
8097684-7	1993	In the anaesthetized water-diuretic rat, low dose somatostatin (60 micrograms/h) increased free water clearance by 23% (P &lt; 0.01), whereas increasing the somatostatin concentration (600 micrograms/h) produced a transitory 40% fall in free water clearance (P &lt; 0.01).	Water	96-101	somatostatin	Rattus norvegicus	50-62
8097684-7	1993	In the anaesthetized water-diuretic rat, low dose somatostatin (60 micrograms/h) increased free water clearance by 23% (P &lt; 0.01), whereas increasing the somatostatin concentration (600 micrograms/h) produced a transitory 40% fall in free water clearance (P &lt; 0.01).	Water	96-101	somatostatin	Rattus norvegicus	50-62
8097684-13	1993	These results suggest that circulating somatostatin may have a physiological role in modulating distal nephron water transport with a low concentration directly inhibiting and a high concentration facilitating water transport.	Water	111-116	somatostatin	Rattus norvegicus	39-51
8097684-13	1993	These results suggest that circulating somatostatin may have a physiological role in modulating distal nephron water transport with a low concentration directly inhibiting and a high concentration facilitating water transport.	Water	210-215	somatostatin	Rattus norvegicus	39-51
8389746-1	1993	Cytochrome c oxidase oxidizes cytochrome c and reduces molecular oxygen to water.	Water	75-80	cytochrome c, somatic	Homo sapiens	0-12
7951507-0	1993	Effects of ether-laparotomy and water immersion-restraint stress on CRH concentration in the hypothalamus, extrahypothalamic tissues and peripheral blood.	Water	32-37	corticotropin releasing hormone	Rattus norvegicus	68-71
7951507-1	1993	The effect of sustained stress on the plasma CRH level was studied in rats subjected to the stress of laparotomy conducted under ether anesthesia or water immersion-restraint.	Water	149-154	corticotropin releasing hormone	Rattus norvegicus	45-48
7951507-6	1993	In the animals subjected to water immersion-restraint stress, plasma CRH tended to increase during the time course of the stress, reaching levels that were at least two times higher than the control.	Water	28-33	corticotropin releasing hormone	Rattus norvegicus	69-72
8388368-2	1993	The tryptic condensation strategy was applied to the synthesis of the 13-peptide, alpha-melanocyte stimulating hormone (alpha-MSH), which contains two susceptible points to trypsin, in a low-water-containing solvent system, 4% H2O in HFIP/DMF (1/1, v/v).	Water	191-196	proopiomelanocortin	Homo sapiens	82-118
8388368-2	1993	The tryptic condensation strategy was applied to the synthesis of the 13-peptide, alpha-melanocyte stimulating hormone (alpha-MSH), which contains two susceptible points to trypsin, in a low-water-containing solvent system, 4% H2O in HFIP/DMF (1/1, v/v).	Water	191-196	proopiomelanocortin	Homo sapiens	120-129
8388368-2	1993	The tryptic condensation strategy was applied to the synthesis of the 13-peptide, alpha-melanocyte stimulating hormone (alpha-MSH), which contains two susceptible points to trypsin, in a low-water-containing solvent system, 4% H2O in HFIP/DMF (1/1, v/v).	Water	227-230	proopiomelanocortin	Homo sapiens	82-118
8388368-2	1993	The tryptic condensation strategy was applied to the synthesis of the 13-peptide, alpha-melanocyte stimulating hormone (alpha-MSH), which contains two susceptible points to trypsin, in a low-water-containing solvent system, 4% H2O in HFIP/DMF (1/1, v/v).	Water	227-230	proopiomelanocortin	Homo sapiens	120-129
7685786-10	1993	Frozen sections of the thyroids and livers from iodine-treated rats were compared to tap-water controls after staining with Mercury Orange for GSH and Schiff"s reagent for evidence of lipid peroxidation.	Water	89-94	nuclear RNA export factor 1	Rattus norvegicus	85-88
7682789-4	1993	Physiologically, ET-1 reversibly and significantly inhibited AVP-stimulated water permeability in inner medullary collecting duct (IMCD).	Water	76-81	endothelin 1	Rattus norvegicus	17-21
7682789-12	1993	As for the osmotic water permeability (microns/s), 10(-8) M ET-1 significantly inhibited this from 320.1 +/- 50.9 to 202.1 +/- 42.2 (n = 7, P &lt; 0.01) in the presence of 10(-9) M AVP.	Water	19-24	endothelin 1	Rattus norvegicus	60-64
8448195-0	1993	Two-dimensional crystallization of catalase on a monolayer film of poly(1-benzyl-L-histidine) spread at the air/water interface.	Water	112-117	catalase	Homo sapiens	35-43
8382948-2	1993	Hexokinase and glycerokinase were found to be specific for the delta beta, gamma-bidentate Rh(H2O)4ATP isomer as substrate while adenylate kinase was found to specifically catalyze the reaction of the delta beta,gamma-bidentate Rh(H2O)4ATP isomer.	Water	94-97	hexokinase 1	Homo sapiens	0-10
15299528-1	1993	The molecular structure of calf gammaB-crystallin (previously called gammaII), a lens-specific protein, has been refined to a crystallographic R factor of 18.1% for all reflection data, between 8.0 and 1.47 A, 25 959 hkl measured at 293 (1) K. 230 water molecules have been defined by difference Fourier techniques and included in a restrained least-squares refinement.	Water	248-253	crystallin gamma B	Bos taurus	32-49
8484016-2	1993	Administration of exogenous EGF modulates the reabsorption of Na+ and the vasopressin stimulated reabsorption of water in the collecting tubules.	Water	113-118	arginine vasopressin	Rattus norvegicus	74-85
8484016-7	1993	IN CONCLUSION: it seems unlikely that nephrogenous EGF excreted in the urine plays a physiological role in the regulation of the renal excretion of Na+ and H+ and in the vasopressin stimulated reabsorption of water in the rat.	Water	209-214	arginine vasopressin	Rattus norvegicus	170-181
8457007-6	1993	Thus, during pregnancy, the lower tonicity of plasma is perceived as normal by both VP and OT neuroendocrine systems enabling excretion of an acute sodium or water load.	Water	158-163	arginine vasopressin	Rattus norvegicus	84-86
8469710-0	1993	Angiotensin II mediates a conditioned taste aversion in water-replete rats.	Water	56-61	angiotensinogen	Rattus norvegicus	0-14
8458096-1	1993	OBJECTIVE: We investigated the effect of growth hormone (GH) treatment on salt and water metabolism and the renin-angiotensin-aldosterone system in children with short stature.	Water	83-88	growth hormone 1	Homo sapiens	41-55
8215714-2	1993	Angiotensin II (100 ng), injected into the preoptic area, and water deprivation increased the intake of water and of a 2.7% NaCl solution in spontaneously hypertensive as well as in Wistar-Kyoto rats.	Water	104-109	angiotensinogen	Rattus norvegicus	0-14
8458096-1	1993	OBJECTIVE: We investigated the effect of growth hormone (GH) treatment on salt and water metabolism and the renin-angiotensin-aldosterone system in children with short stature.	Water	83-88	growth hormone 1	Homo sapiens	57-59
8458096-14	1993	Clinical signs consistent with transient salt and water retention are observed with GH therapy, however, suggesting either a direct effect of GH or of IGF-I on renal tubular function.	Water	50-55	growth hormone 1	Homo sapiens	84-86
8319653-11	1993	Consumption of water containing 15 ppm monochloramine may be associated with increased levels of plasma apolipoprotein B.	Water	15-20	apolipoprotein B	Homo sapiens	104-120
8003705-3	1993	Treatment with TRH resulted in significantly increased hypothalamic vasopressin content in both euhydrated (i.e. given tap water ad libitum) and salt-loaded rats.	Water	123-128	arginine vasopressin	Rattus norvegicus	68-79
8450052-1	1993	Recent evidence has implicated endothelin-1 (ET-1) as an autocrine inhibitor of inner medullary collecting duct (IMCD) sodium and water transport.	Water	130-135	endothelin 1	Rattus norvegicus	31-43
8450052-1	1993	Recent evidence has implicated endothelin-1 (ET-1) as an autocrine inhibitor of inner medullary collecting duct (IMCD) sodium and water transport.	Water	130-135	endothelin 1	Rattus norvegicus	45-49
8450052-9	1993	We speculate that extracellular sodium concentration, via regulation of ET-1 production, provides a link between volume status and IMCD sodium and water reabsorption.	Water	147-152	endothelin 1	Rattus norvegicus	72-76
8094956-3	1993	We have undertaken a detailed NMR conformational study in a DMSOd6/H2O cryomixture at 278 K of the CCK analog H-Arg-Asp-Tyr(SO3H)-Thr-Gly-Trp-Nle-Asp-PheNH2 (CCK9) which retains all the bioactivities of CCK8, but was found to be remarkably more stable in acidic media and unaffected by air oxidation due to Met replacements.	Water	67-70	cholecystokinin	Homo sapiens	99-102
8476775-3	1993	In the experiments described here the presence of aromatase (assayed by the tritiated water method) has been evaluated in the two main cellular components of the brain: neurons and glia.	Water	86-91	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	50-59
8474636-0	1993	Effect of paraventricular injection of neuropeptide Y on milk and water intake of preweanling rats.	Water	66-71	neuropeptide Y	Rattus norvegicus	39-53
8474636-6	1993	Injection of NPY into the PVN enhanced milk and water intake equally at 2 days of age.	Water	48-53	neuropeptide Y	Rattus norvegicus	13-16
8464801-9	1993	Supplementing the saline drinking water with any of the three Zn compounds significantly reduced the incidence of eggshell defects and in some cases improved shell breaking strength, the concentration of CaBP, and the activity of CA.	Water	34-39	calcium-binding protein	Gallus gallus	204-208
8096392-2	1993	Water homeostasis is regulated by arginine vasopressin (AVP), the renin-angiotensin system and natriuretic hormones.	Water	0-5	arginine vasopressin	Homo sapiens	43-54
8096392-2	1993	Water homeostasis is regulated by arginine vasopressin (AVP), the renin-angiotensin system and natriuretic hormones.	Water	0-5	renin	Homo sapiens	66-71
8395245-2	1993	The enzymatic activity of purified human 5-lipoxygenase was dependent on the ratio of arachidonic acid to phospholipids rather than on the bulk arachidonic acid concentration, suggesting that the concentration of substrate at the lipid-water interface is important for the rate of the 5-LO reaction.	Water	236-241	arachidonate 5-lipoxygenase	Homo sapiens	41-55
8236531-6	1993	Alcohol dehydrogenase reaction maximum speed for short-sleeping group is close to that for animals preferring ethanol or water.	Water	121-126	aldo-keto reductase family 1 member A1	Rattus norvegicus	0-21
7679107-1	1993	Lysozyme and 10 other proteins are solubilized in reverse micelles formed by 0.1 M sodium di-2-ethyl-hexylsulfosuccinate and 2.0-2.5 M water (pH 7.4) in isooctane solvent.	Water	135-140	lysozyme	Homo sapiens	0-8
8436142-10	1993	The former pKa value probably represents ionization of an imidazole group and the latter the zinc/water ionization in SDH.	Water	98-103	L-iditol 2-dehydrogenase	Ovis aries	118-121
8381363-2	1993	The H-D exchange reaction was initiated by transferring the lysozyme adsorbed on hydroxyapatite powder from H2O into D2O.	Water	108-111	lysozyme	Homo sapiens	60-68
8434831-11	1993	Dextrose 5% water is the primary vehicle for drug delivery during CPR.	Water	12-17	cytochrome p450 oxidoreductase	Homo sapiens	66-69
8429910-2	1993	Concentrated urine is produced in response to vasopressin by the transepithelial recovery of water from the lumen of the kidney collecting tubule through highly water-permeable membranes.	Water	93-98	arginine vasopressin	Rattus norvegicus	46-57
8429910-2	1993	Concentrated urine is produced in response to vasopressin by the transepithelial recovery of water from the lumen of the kidney collecting tubule through highly water-permeable membranes.	Water	161-166	arginine vasopressin	Rattus norvegicus	46-57
8429910-3	1993	In this nephron segment, vasopressin regulates water permeability by endo- and exocytosis of water channels from or to the apical membrane.	Water	47-52	arginine vasopressin	Rattus norvegicus	25-36
8417817-5	1993	Intestinal alkaline phosphatase activity in fecal water was measured with the use of the uncompetitive inhibitor L-phenylalanine.	Water	50-55	alkaline phosphatase, intestinal	Homo sapiens	0-31
7680915-5	1993	Failure of the CFTR channel in CF reduces epithelial salt and water secretion, leading to a dehydration of epithelial surfaces which initiates the pathology of the disease.	Water	62-67	CF transmembrane conductance regulator	Homo sapiens	15-19
8430879-6	1993	After maternal water access maternal plasma AVP decreased rapidly in comparison to the gradual decrease in maternal pOSM.	Water	15-20	arginine vasopressin	Homo sapiens	44-47
8427657-5	1993	These results suggest that the secretion of EPO is increased in response to hemodilution caused by the salt loading and the increased EPO concentration in plasma which may contribute to the increase in blood pressure through an expansion of total blood volume due to an enhanced red cell generation in combination with salt and water retentions.	Water	328-333	erythropoietin	Homo sapiens	44-47
8427657-5	1993	These results suggest that the secretion of EPO is increased in response to hemodilution caused by the salt loading and the increased EPO concentration in plasma which may contribute to the increase in blood pressure through an expansion of total blood volume due to an enhanced red cell generation in combination with salt and water retentions.	Water	328-333	erythropoietin	Homo sapiens	134-137
8380616-8	1993	The perfect duplex contains three A.T basepairs as expected, resulting in three very intense T imino-AH2 cross-peaks in the H2O NOESY experiment.	Water	124-127	zinc finger RANBP2-type containing 3	Homo sapiens	101-104
8213931-10	1993	The patients with environmental risk factors (professional exposure, tap water consumption and older houses) had PbC levels higher than patients without (p = 0.01).	Water	73-78	dihydrolipoamide S-acetyltransferase	Homo sapiens	113-116
8430881-5	1993	Water intakes to both doses of intracerebroventricular ANG II were increased, and UV and electrolyte excretion were reduced during hypotensive conditions compared with normotensive conditions.	Water	0-5	angiotensinogen	Rattus norvegicus	55-61
8453484-2	1993	A low dose (5 ng) of KA, which stimulates neurons, decreased the amount of water intake induced by hypertonic saline (IP) and angiotensin II (SC).	Water	75-80	angiotensinogen	Rattus norvegicus	126-140
8453484-8	1993	The rats normally drank water in response to angiotensin II and to polyethylene glycol solution.	Water	24-29	angiotensinogen	Rattus norvegicus	45-59
8457908-1	1993	Lateral ventricular administration of angiotensin II (ANG II) produces potent dipsogenic effects in water-sated rats.	Water	100-105	angiotensinogen	Rattus norvegicus	38-52
8448971-2	1993	The atrial natriuretic peptide (ANP) is part of a new family of cardiac hormones regulating water and salt homeostasis.	Water	92-97	natriuretic peptide A	Homo sapiens	4-30
8457908-1	1993	Lateral ventricular administration of angiotensin II (ANG II) produces potent dipsogenic effects in water-sated rats.	Water	100-105	angiotensinogen	Rattus norvegicus	54-60
8448971-2	1993	The atrial natriuretic peptide (ANP) is part of a new family of cardiac hormones regulating water and salt homeostasis.	Water	92-97	natriuretic peptide A	Homo sapiens	32-35
8071467-5	1993	The observed correlation between plasma atrial natriuretic factor concentration and vascular volume together with the atrial natriuretic factor-induced modulation of renal salt and water elimination is consistent with the concept that in the chicken this peptide has a physiological role as a regulatory hormone in volume homeostasis.	Water	181-186	natriuretic peptide A	Gallus gallus	118-143
8262469-0	1993	Effects of growth hormone on the metabolism of lipids and water and their potential in causing adverse events during growth hormone treatment.	Water	58-63	growth hormone 1	Homo sapiens	11-25
8262469-0	1993	Effects of growth hormone on the metabolism of lipids and water and their potential in causing adverse events during growth hormone treatment.	Water	58-63	growth hormone 1	Homo sapiens	117-131
8448448-2	1993	The water sample is first passed through a cartridge or disk containing a solid matrix coated with a chemically bonded C18 organic phase capable of extracting those organic compounds.	Water	4-9	Bardet-Biedl syndrome 9	Homo sapiens	119-122
8144705-4	1993	In the principal cell, the antidiuretic hormone, vasopressin, induces the insertion of vesicles that contain proteinaceous water channels into the apical cell membrane, thus increasing the permeability to water of the epithelial layer.	Water	123-128	arginine vasopressin	Homo sapiens	49-60
8144705-4	1993	In the principal cell, the antidiuretic hormone, vasopressin, induces the insertion of vesicles that contain proteinaceous water channels into the apical cell membrane, thus increasing the permeability to water of the epithelial layer.	Water	205-210	arginine vasopressin	Homo sapiens	49-60
8380375-1	1993	The contribution of the magnocellular vasopressinergic system to the regulation of ACTH secretion was studied by analysis of hypothalamic-adrenal axis function in rats subjected to water deprivation for 48 h. Water deprivation resulted in marked increases in plasma osmolarity and vasopressin (VP) levels and hypothalamic VP mRNA and immunoreactive (ir) VP in magnocellular neurons.	Water	209-214	arginine vasopressin	Rattus norvegicus	38-49
8454567-5	1993	The upfield shift of 2-13C of MCAD relative to that of FMN in the aqueous medium and its downfield shift relative to that of tetraacetylriboflavin in an apolar medium imply that a weaker hydrogen bond exists between C(2) = O and apoMCAD or a water molecule than that of free FMN with a water molecule.	Water	242-247	acyl-CoA dehydrogenase medium chain	Homo sapiens	30-34
8454567-5	1993	The upfield shift of 2-13C of MCAD relative to that of FMN in the aqueous medium and its downfield shift relative to that of tetraacetylriboflavin in an apolar medium imply that a weaker hydrogen bond exists between C(2) = O and apoMCAD or a water molecule than that of free FMN with a water molecule.	Water	286-291	acyl-CoA dehydrogenase medium chain	Homo sapiens	30-34
7775887-3	1993	The amount of insecticide residue detected using GLC indicated that, tap water, sodium hydroxide solution and potassium permanganate solution gave high percent removal.	Water	73-78	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	69-72
8349883-8	1993	In vivo water uptake in tap water acclimated animals was very small, and was higher in the other groups.	Water	8-13	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) L homeolog	Xenopus laevis	24-27
8349883-8	1993	In vivo water uptake in tap water acclimated animals was very small, and was higher in the other groups.	Water	28-33	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) L homeolog	Xenopus laevis	24-27
8350667-1	1993	Using the toad urinary bladder, we examined the effects of submaximal levels of atrial natriuretic factor (ANF) upon the hydroosmotic water flux caused by physiologic concentrations of vasopressin (VP).	Water	134-139	natriuretic peptide A	Homo sapiens	80-105
8298608-3	1993	It is known that VIP has various effects on intestinal functions: i) it is a potent stimulant of mucosal water and electrolyte secretion; ii) it is involved in the peristaltic reflex; and iii) plays an inhibitory role on immune cell function.	Water	105-110	vasoactive intestinal peptide	Homo sapiens	17-20
8350667-1	1993	Using the toad urinary bladder, we examined the effects of submaximal levels of atrial natriuretic factor (ANF) upon the hydroosmotic water flux caused by physiologic concentrations of vasopressin (VP).	Water	134-139	natriuretic peptide A	Homo sapiens	107-110
8350667-1	1993	Using the toad urinary bladder, we examined the effects of submaximal levels of atrial natriuretic factor (ANF) upon the hydroosmotic water flux caused by physiologic concentrations of vasopressin (VP).	Water	134-139	arginine vasopressin	Homo sapiens	185-196
8350667-2	1993	Pretreatment with ANF prior to the addition of VP (10(-9)M) significantly enhanced water transport (123 +/- 23%) compared to tissues exposed to VP alone.	Water	83-88	natriuretic peptide A	Homo sapiens	18-21
8350667-2	1993	Pretreatment with ANF prior to the addition of VP (10(-9)M) significantly enhanced water transport (123 +/- 23%) compared to tissues exposed to VP alone.	Water	83-88	arginine vasopressin	Homo sapiens	47-49
8350667-4	1993	When the concentration of VP was progressively increased during time course experiments, an inhibitory effect of ANF on water transport followed the early stimulatory response to this peptide.	Water	120-125	arginine vasopressin	Homo sapiens	26-28
8350667-4	1993	When the concentration of VP was progressively increased during time course experiments, an inhibitory effect of ANF on water transport followed the early stimulatory response to this peptide.	Water	120-125	natriuretic peptide A	Homo sapiens	113-116
8350667-6	1993	Moreover, the stimulatory effect of submaximal doses of ANF to cyclic-AMP mediated water transport suggest the possibility that modulation by ANF may occur at a site following the VP receptor-linked adenylate cyclase system.	Water	83-88	natriuretic peptide A	Homo sapiens	56-59
8350667-6	1993	Moreover, the stimulatory effect of submaximal doses of ANF to cyclic-AMP mediated water transport suggest the possibility that modulation by ANF may occur at a site following the VP receptor-linked adenylate cyclase system.	Water	83-88	natriuretic peptide A	Homo sapiens	142-145
1447179-10	1992	Moreover, through the information of the tertiary structures of the apo- and holomutant lysozyme, it was confirmed that the entropy release (10 kcal/mol) upon the binding of Ca2+ arises primarily from the release of bound water molecules hydrating the free Ca2+.	Water	222-227	lysozyme	Homo sapiens	88-96
1334431-2	1992	We found 16 equivalent water sites conserved in trypsin/ogen, chymotrypsin/ogen, elastase, kallikrein, thrombin, rat tonin and rat mast cell protease, and 5 additional water sites in enzymes which share the primary specificity of trypsin.	Water	23-28	coagulation factor II	Rattus norvegicus	103-111
1471690-8	1992	Fetal plasma arginine vasopressin concentration increased during indomethacin infusion (p &lt; 0.05) and was correlated with the fall in urinary flow rate and free water clearance (p = 0.002).	Water	164-169	arginine vasopressin	Homo sapiens	22-33
1339167-3	1992	Treatment of the water-soluble LH/hCG receptor occurring in follicular fluid with PL-A2 produced no inhibitory effect on gonadotropin binding in spite of digestion of phospholipids.	Water	17-22	phospholipase A2 group IB	Homo sapiens	82-87
1362543-3	1992	The diuretic-induced loss of salt and water activates several hormonal systems such as vasopressin, the renin-angiotensin-aldosterone system or the sympathetic nervous system which tend to compensate for the changes in sodium and water balance.	Water	38-43	renin	Homo sapiens	104-109
1471690-11	1992	The reduction in free water clearance may be mediated by increases in plasma arginine vasopressin concentrations.	Water	22-27	arginine vasopressin	Homo sapiens	86-97
1431262-4	1992	The increase of rCBF and brain water content in infected untreated rats was significantly attenuated by catalase 6 h after intracisternal challenge.	Water	31-36	catalase	Rattus norvegicus	104-112
1448828-1	1992	BACKGROUND AND PURPOSE: Injection of arginine vasopressin into the cerebral ventricles in animals with brain injury increased brain water, whereas injection of atrial natriuretic peptide reduced water content.	Water	132-137	arginine vasopressin	Rattus norvegicus	46-57
1488127-3	1992	In animals not allowed access to water after infusion, angiotensin II induced intense c-fos expression in a band of neurons extending throughout the anterior region of the third ventricle region, including the organum vasculosum of the lamina terminalis, the median preoptic nucleus (nucleus medianus) and the subfornical organ.	Water	33-38	angiotensinogen	Rattus norvegicus	55-69
1363933-3	1992	The molecular mass of this modified species was determined by electrospray mass spectrometry to be 18 Da less than normal porcine somatotropin, indicative of a loss of 1 H2O molecule.	Water	170-173	growth hormone 1	Homo sapiens	130-142
1487697-3	1992	These differences were fully reversed after 7 days of vasopressin replacement in DI rats to restore normal water turnover.	Water	107-112	arginine vasopressin	Rattus norvegicus	54-65
1337114-1	1992	Vasopressin is thought to play an important role, not only in the metabolism of water and electrolytes, but also in the regulation of renal hemodynamics.	Water	80-85	arginine vasopressin	Rattus norvegicus	0-11
1448828-7	1992	RESULTS: The arginine vasopressin V1 receptor antagonist and atrial natriuretic peptide significantly (p &lt; 0.05) reduced water and sodium contents in the posterior edematous regions.	Water	124-129	arginine vasopressin	Rattus norvegicus	22-33
1336524-8	1992	Angiotensin II alone also increased fractional reabsorption of sodium delivered to the distal nephron, as evaluated by both the CLi method and by estimation of solute-free water clearance.	Water	172-177	angiotensinogen	Homo sapiens	0-14
1332612-2	1992	Fractionation of organic extracts by thin layer chromatography in chloroform/acetone/methanol/acetic acid/water (50/20/10/10/5, v/v) revealed two insulin-sensitive glucosaminyl lipid fractions, the TLC origin (the Rf 0.0 fraction) and a fraction that migrated with Rf 0.18-0.2 (the Rf 0.2 fraction).	Water	106-111	insulin	Homo sapiens	146-153
1426259-0	1992	A critical role of protein-bound water in the catalytic cycle of cytochrome P-450 camphor.	Water	33-38	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-81
1415001-0	1992	Is the impedance index (ht2/R) significant in predicting total body water?	Water	68-73	telomerase RNA component	Homo sapiens	24-29
1415001-4	1992	The single best predictor of total body water (TBW) was height2/resistance (ht2/R), which explained 99% of the variation in TBW (SEE = 1.67 kg).	Water	40-45	telomerase RNA component	Homo sapiens	56-81
1332568-7	1992	As elevated serum AVP levels may not be clinically apparent unless associated with excessive water ingestation, it is possible that an even higher percentage of patients may have increased serum AVP levels.	Water	93-98	arginine vasopressin	Homo sapiens	18-21
16348811-5	1992	The average bacterial size was always larger in water which was passed through 1-mum-pore-size filters (1-mum-filtered water) (which was predator free) than in 5-mum-filtered water (which contained flagellates only) or in unfiltered water (in which all bacterivores were present).	Water	119-124	latexin	Homo sapiens	106-109
16348811-5	1992	The average bacterial size was always larger in water which was passed through 1-mum-pore-size filters (1-mum-filtered water) (which was predator free) than in 5-mum-filtered water (which contained flagellates only) or in unfiltered water (in which all bacterivores were present).	Water	119-124	latexin	Homo sapiens	106-109
16348811-6	1992	The increase of bacterial-cell size in 1-mum-filtered water was caused by a shift in the size structure of the bacterioplankton population.	Water	54-59	latexin	Homo sapiens	41-44
1335395-13	1992	Free water clearance was significantly reduced in normal subjects during the arginine vasopressin infusion from 8.19 +/- 2.61 to -1.41 +/- 0.51 ml/min (P &lt; 0.001), but was unchanged in the patients with renal failure after attaining comparable plasma arginine vasopressin concentrations.	Water	5-10	arginine vasopressin	Homo sapiens	86-97
1335395-13	1992	Free water clearance was significantly reduced in normal subjects during the arginine vasopressin infusion from 8.19 +/- 2.61 to -1.41 +/- 0.51 ml/min (P &lt; 0.001), but was unchanged in the patients with renal failure after attaining comparable plasma arginine vasopressin concentrations.	Water	5-10	arginine vasopressin	Homo sapiens	263-274
1416134-9	1992	In the positive pressure technique of cuff inflation (PPT), the blocker lumen was connected to a beaker of water while maintaining pressure of +30 mm Hg within the breathing system.	Water	107-112	tachykinin precursor 1	Homo sapiens	54-57
16348811-5	1992	The average bacterial size was always larger in water which was passed through 1-mum-pore-size filters (1-mum-filtered water) (which was predator free) than in 5-mum-filtered water (which contained flagellates only) or in unfiltered water (in which all bacterivores were present).	Water	48-53	latexin	Homo sapiens	81-84
16348811-5	1992	The average bacterial size was always larger in water which was passed through 1-mum-pore-size filters (1-mum-filtered water) (which was predator free) than in 5-mum-filtered water (which contained flagellates only) or in unfiltered water (in which all bacterivores were present).	Water	119-124	latexin	Homo sapiens	106-109
16348811-5	1992	The average bacterial size was always larger in water which was passed through 1-mum-pore-size filters (1-mum-filtered water) (which was predator free) than in 5-mum-filtered water (which contained flagellates only) or in unfiltered water (in which all bacterivores were present).	Water	119-124	latexin	Homo sapiens	106-109
16348811-5	1992	The average bacterial size was always larger in water which was passed through 1-mum-pore-size filters (1-mum-filtered water) (which was predator free) than in 5-mum-filtered water (which contained flagellates only) or in unfiltered water (in which all bacterivores were present).	Water	119-124	latexin	Homo sapiens	106-109
16348811-5	1992	The average bacterial size was always larger in water which was passed through 1-mum-pore-size filters (1-mum-filtered water) (which was predator free) than in 5-mum-filtered water (which contained flagellates only) or in unfiltered water (in which all bacterivores were present).	Water	119-124	latexin	Homo sapiens	106-109
1428117-1	1992	Endothelin-1 inhibits sodium and water transport systems in the inner medullary collecting duct.	Water	33-38	endothelin 1	Rattus norvegicus	0-12
1428117-2	1992	Endothelin-1 levels are reduced in the medulla of spontaneously hypertensive rats (SHR), raising the possibility that decreased inner medullary collecting duct production of endothelin-1 could contribute to inappropriate sodium and water retention.	Water	232-237	endothelin 1	Rattus norvegicus	174-186
1415733-2	1992	This segment of the nephron synthesizes ET-1, expresses endothelin receptors, and responds to exogenous ET-1 by reducing Na(+)-K(+)-ATPase activity and water transport.	Water	152-157	endothelin 1	Rattus norvegicus	104-108
1445672-2	1992	Conversion of ap-9-pivaloylfluorene, ap-(I), into lithiated (I)-9-anion followed by the addition of MeOH, then H2O, led to unexpected hydroxylation to provide 20-40% of sp-9-hydroxy-9-pivaloyfluorene, sp-(II), and 60-80% recovery of ap-(I).	Water	111-114	Sp9 transcription factor	Homo sapiens	169-173
1445672-2	1992	Conversion of ap-9-pivaloylfluorene, ap-(I), into lithiated (I)-9-anion followed by the addition of MeOH, then H2O, led to unexpected hydroxylation to provide 20-40% of sp-9-hydroxy-9-pivaloyfluorene, sp-(II), and 60-80% recovery of ap-(I).	Water	111-114	integrin binding sialoprotein	Homo sapiens	201-207
1329565-7	1992	2) ANG II blockade blunted the glucocorticoid and ACTH responses to hypotension in water-deprived dogs, but not water-replete dogs.	Water	83-88	proopiomelanocortin	Canis lupus familiaris	50-54
1329565-8	1992	In contrast, vasopressin blockade reduced the ACTH response only in water-replete dogs.	Water	68-73	proopiomelanocortin	Canis lupus familiaris	46-50
1329565-9	1992	3) Vasopressin or combined vasopressin and ANG II blockade reduced the plasma level of glucocorticoids related either to the fall in arterial pressure or to the increase in plasma ACTH concentration in water-replete dogs, and this effect was enhanced in water-deprived dogs.	Water	202-207	proopiomelanocortin	Canis lupus familiaris	180-184
1390775-1	1992	The fibronectin C-terminal interchain disulfide-linked heptapeptide dimer (Val-Asn-Cys-Pro-Ile-Glu-Cys)2 has been investigated via 1H NMR spectroscopy in both water and dimethyl sulfoxide (DMSO) solutions.	Water	159-164	fibronectin 1	Homo sapiens	4-15
1333144-1	1992	Biological activity of water soluble fractions F-1 and F-2, which were extracted from hop, was studied and its action mechanism was speculated using the immature female SD rats.	Water	23-28	coagulation factor II	Rattus norvegicus	55-58
1333144-1	1992	Biological activity of water soluble fractions F-1 and F-2, which were extracted from hop, was studied and its action mechanism was speculated using the immature female SD rats.	Water	23-28	stress-induced phosphoprotein 1	Rattus norvegicus	86-89
1415100-8	1992	Altered relationships between intrarenal hormone systems, such as the renin-angiotensin and kallikrein-kinin systems, may be important in salt and water retention.	Water	147-152	renin	Homo sapiens	70-75
1327601-6	1992	By inhibiting this potent vasoconstrictor and suppressing its degradation of the powerful vasodilator bradykinin, and by promoting sodium and water excretion, ACE inhibitors contribute to the restoration of normal ventricular function.	Water	142-147	angiotensin I converting enzyme	Homo sapiens	159-162
1280488-7	1992	The values for pure water permeability and overall mass transfer coefficients for urea, creatinine, and vitamin B12 are quite adequate for hemodialysis.	Water	20-25	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	112-115
1490249-0	1992	Role of sodium and water excretion in the antihypertensive effect of vasopressin in the spontaneously hypertensive rat.	Water	19-24	arginine vasopressin	Rattus norvegicus	69-80
1416418-0	1992	Effect of atrial natriuretic peptide given by intravenous infusion on bronchoconstriction induced by ultrasonically nebulized distilled water (fog).	Water	136-141	zinc finger protein, FOG family member 1	Homo sapiens	143-146
1416418-2	1992	Bronchoconstriction caused by inhalation of ultrasonically nebulized distilled water (fog), in contrast to histamine-induced bronchoconstriction, has features in common with exercise-induced asthma but can be given more easily in a dose-response fashion.	Water	79-84	zinc finger protein, FOG family member 1	Homo sapiens	86-89
1447076-2	1992	Catalase or DMSO significantly prevented the increase in plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha over 3 h after alloxan and the accumulation of extravascular lung water after 3 h [3.95 +/- 0.52 (SE) g/g with catalase, 3.06 +/- 0.42 g/g with DMSO] but not early pulmonary arterial pressor response.	Water	179-184	catalase	Canis lupus familiaris	0-8
1328300-0	1992	Endothelin inhibits vasopressin-stimulated water permeability in rat terminal inner medullary collecting duct.	Water	43-48	arginine vasopressin	Rattus norvegicus	20-31
1328300-2	1992	To characterize direct effects of the recently discovered peptide endothelin (ET) on renal tubule transport, we determined signaling mechanisms for ET effects on vasopressin (AVP)-stimulated water permeability (PF) in rat terminal inner medullary collecting duct (IMCD) perfused in vitro.	Water	191-196	arginine vasopressin	Rattus norvegicus	162-173
1435164-5	1992	For a given VO2, heart rate was 8-11 beats.min-1 lower during water running than during treadmill running, irrespective of exercise intensity.	Water	62-67	CD59 molecule (CD59 blood group)	Homo sapiens	43-48
1394607-0	1992	Vasopressin antagonist disrupts the circadian rhythm of water intake on suprachiasmatic injection.	Water	56-61	arginine vasopressin	Rattus norvegicus	0-11
1394607-1	1992	The present study makes an attempt to find out the action of arginine vasopressin (AVP) and its antagonist d-(CH2)5 Tyr (Me) AVP applied at the suprachiasmatic nuclei (SCN) on the circadian rhythm of water intake.	Water	200-205	arginine vasopressin	Rattus norvegicus	70-81
1394607-1	1992	The present study makes an attempt to find out the action of arginine vasopressin (AVP) and its antagonist d-(CH2)5 Tyr (Me) AVP applied at the suprachiasmatic nuclei (SCN) on the circadian rhythm of water intake.	Water	200-205	arginine vasopressin	Rattus norvegicus	83-86
1394607-1	1992	The present study makes an attempt to find out the action of arginine vasopressin (AVP) and its antagonist d-(CH2)5 Tyr (Me) AVP applied at the suprachiasmatic nuclei (SCN) on the circadian rhythm of water intake.	Water	200-205	arginine vasopressin	Rattus norvegicus	125-128
1394607-5	1992	The findings are suggestive of the involvement of AVP as a mediator of the circadian rhythm of water intake at the level of the neural pacemaker, SCN.	Water	95-100	arginine vasopressin	Rattus norvegicus	50-53
1388176-1	1992	Endocytic vesicles that are involved in the vasopressin-stimulated recycling of water channels to and from the apical membrane of kidney collecting duct principal cells were isolated from rat renal papilla by differential and Percoll density gradient centrifugation.	Water	80-85	arginine vasopressin	Rattus norvegicus	44-55
1338105-0	1992	Effect of colcemid on the water permeability response to vasopressin in isolated perfused rabbit collecting tubules.	Water	26-31	arginine vasopressin	Homo sapiens	57-68
1338105-2	1992	The effect of the microtubule-disruptive agent, colcemid (N-deacetyl-N-methyl-colchicine), on the water permeability response to vasopressin has been investigated in isolated cortical collecting tubules from the rabbit kidney perfused in vitro.	Water	98-103	arginine vasopressin	Homo sapiens	129-140
1338105-4	1992	Pretreatment of collecting tubules with colcemid inhibited the increase in water permeability elicited by vasopressin, 50 microU ml-1, in a time- and dose-dependent manner.	Water	75-80	arginine vasopressin	Homo sapiens	106-117
1357660-9	1992	In conclusion, the results of the present study indicate a direct catalytic role for Glu-296 in the peptidase reaction of LTA4 hydrolase, where it presumably acts as a base to polarize water, whereas its function, if any, is apparently not essential in the epoxide hydrolase reaction.	Water	185-190	leukotriene A4 hydrolase	Homo sapiens	122-136
1279517-5	1992	A direct correlation between the value of ADH-stimulated water flow, cAMP content in bladder tissue and frequency of particle aggregates in the granular cell apical membrane was observed.	Water	57-62	arginine vasopressin	Homo sapiens	42-45
16653067-3	1992	Exudation of sap from stem segments subjected to freeze/thaw cycles was small (&lt;10 mL/kg) in the fall, but substantial exudation (45-50 mL/kg) occurred following the decline in water content.	Water	180-185	SH2 domain containing 1A	Homo sapiens	13-16
16653067-9	1992	Exudation volume was increased 200 to 300% in maple stems originally at high water content (&gt;0.80) after perfusion with sucrose and dehydration at -12 degrees C. Sap flow was also induced in butternut stem segments after the same treatment.	Water	77-82	SH2 domain containing 1A	Homo sapiens	165-168
16653067-11	1992	Sap flow could not be increased in stem segments dehydrated at 4 degrees C. Migration of water molecules from small ice crystals in fibers to larger crystals in vessels while stems were frozen may account for increase exudation after dehydration at -12 degrees C. This would result in preferential dehydration of fibers and a distribution of gas and sap favorable for stem-based sap flow.	Water	89-94	SH2 domain containing 1A	Homo sapiens	0-3
1525155-6	1992	The absence of side chains at the P2 and P1" positions of this inhibitor allows water molecules to occupy the respective pockets in the complex.	Water	80-85	inorganic pyrophosphatase 1	Homo sapiens	34-43
16653067-11	1992	Sap flow could not be increased in stem segments dehydrated at 4 degrees C. Migration of water molecules from small ice crystals in fibers to larger crystals in vessels while stems were frozen may account for increase exudation after dehydration at -12 degrees C. This would result in preferential dehydration of fibers and a distribution of gas and sap favorable for stem-based sap flow.	Water	89-94	SH2 domain containing 1A	Homo sapiens	350-353
16653067-11	1992	Sap flow could not be increased in stem segments dehydrated at 4 degrees C. Migration of water molecules from small ice crystals in fibers to larger crystals in vessels while stems were frozen may account for increase exudation after dehydration at -12 degrees C. This would result in preferential dehydration of fibers and a distribution of gas and sap favorable for stem-based sap flow.	Water	89-94	SH2 domain containing 1A	Homo sapiens	379-382
16653072-2	1992	beta-Amylase activity increased during caryopsis development to a maximum value at the beginning of the water content plateau (at this stage the enzyme was located primarily within the pericarp) and then decreased.	Water	104-109	beta-amylase	Zea mays	0-12
18965533-1	1992	Single-phase solutions (1.72 x 10(-2)M in TTA) of water/ethanol/MIBK, when added to an excess of water, break down into two immiscible liquid layers and TTA complexes of Fe(III), Co(II), Ni(II), Cu(II) and PB(II) are extracted into the organic layer.	Water	50-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
1390631-1	1992	Fluorescence quenching and energy-transfer studies have been carried out to determine the position of FAD and FMN groups of NADPH-cytochrome P450 reductase and of the heme and substrate groups of cytochrome P450 with respect to the lipid/water interphase.	Water	238-243	cytochrome p450 oxidoreductase	Homo sapiens	124-155
1526967-0	1992	Functional reconstitution of the isolated erythrocyte water channel CHIP28.	Water	54-59	aquaporin 1 (Colton blood group)	Homo sapiens	68-74
1526967-6	1992	We report direct evidence that CHIP28 is the erythrocyte water channel.	Water	57-62	aquaporin 1 (Colton blood group)	Homo sapiens	31-37
1526967-12	1992	These data establish a procedure to reconstitute functional water channels into liposomes and demonstrate that CHIP28 is the erythrocyte water channel.	Water	60-65	aquaporin 1 (Colton blood group)	Homo sapiens	111-117
1526967-12	1992	These data establish a procedure to reconstitute functional water channels into liposomes and demonstrate that CHIP28 is the erythrocyte water channel.	Water	137-142	aquaporin 1 (Colton blood group)	Homo sapiens	111-117
1467344-1	1992	Two-dimensional NMR studies were performed on the complexes of porcine pancreatic phospholipase A2, bound to a micellar lipid-water interface of fully deuterated dodecylphosphocholine, with competitive inhibitors derived from the following general structure: [formula: see text] X and Y are alkyl chains with various "reporter groups".	Water	126-131	phospholipase A2 group IB	Homo sapiens	82-98
1415580-8	1992	Induction of water diuresis was not secondary to an inhibition of vasopressin secretion since it could be demonstrated in homozygous Brattleboro rats in which antidiuresis was produced by the infusion of vasopressin at a rate of 200 microU.kg-1.min-1.	Water	13-18	arginine vasopressin	Rattus norvegicus	204-215
1457334-4	1992	This review concentrates on the effects of GH (derived from either pituitary or recombinant technology) and IGF-1 in three main areas: (1) sodium and water homeostasis; (2) calcium and phosphate balance, bone density and interactions with mineral regulating hormones; (3) fat and lean body mass.	Water	150-155	growth hormone 1	Homo sapiens	43-45
1393612-1	1992	Nonpeptide angiotensin AT-1 and AT-2 receptor antagonists were administered cerebroventricularly to rats and their effects on various types of angiotensin II (AII)-stimulated water and NaCl intakes examined.	Water	175-180	angiotensinogen	Rattus norvegicus	143-157
1393612-1	1992	Nonpeptide angiotensin AT-1 and AT-2 receptor antagonists were administered cerebroventricularly to rats and their effects on various types of angiotensin II (AII)-stimulated water and NaCl intakes examined.	Water	175-180	angiotensinogen	Rattus norvegicus	159-162
1393612-2	1992	The AT-1 receptor blocker, losartan potassium (DUP 753), inhibited water intake evoked by central administration of AII, with the 50% inhibitory dose being less than 0.1 microgram.	Water	67-72	angiotensinogen	Rattus norvegicus	116-119
1393612-3	1992	The functional inhibition by higher doses lasted at least 1 h. The AT-2 receptor antagonist PD 123319 also inhibited AII-induced water intake, but at doses about tenfold higher than losartan.	Water	129-134	angiotensinogen	Rattus norvegicus	117-120
1500196-4	1992	Three forms of LPS (H+ form, Mg2+ salt, and triethanolamine salt) showed different solubilities in water, the acidic form of LPS, with the most pronounced hydrophobic properties, being capable of practically complete association with liposomal membranes.	Water	99-104	toll-like receptor 4	Mus musculus	15-18
1500196-4	1992	Three forms of LPS (H+ form, Mg2+ salt, and triethanolamine salt) showed different solubilities in water, the acidic form of LPS, with the most pronounced hydrophobic properties, being capable of practically complete association with liposomal membranes.	Water	99-104	toll-like receptor 4	Mus musculus	125-128
1447418-3	1992	The comparative study of the inhibitory action of water-soluble derivatives of hindered phenols and fatty-soluble ionol made it possible to reveal possible contributions to the inhibition of both direct and mediated (by the membrane microsurroundings) effects on the membrane-bound AChE by the studied synthetic bioantioxidants.	Water	50-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	282-286
1432637-0	1992	Preparation of neurotensin analogue-containing poly(dl-lactic acid) microspheres formed by oil-in-water solvent evaporation.	Water	98-103	neurotensin	Homo sapiens	15-26
1387698-6	1992	Urinary albumin excretion was significantly increased in salt-loaded groups (1,790 +/- 272 micrograms/d in control, 1,617 +/- 174 micrograms/d in NIDDM rats) compared with tap-water groups (691 +/- 75 micrograms/d in control, P less than .05; 616 +/- 69 micrograms/d in NIDDM rats, P less than .001), irrespective of STZ injection, but endogenous creatinine clearance was not different among the groups.	Water	176-181	nuclear RNA export factor 1	Rattus norvegicus	172-175
1333262-2	1992	Spin-echo spectra with long TEs (270 ms; water suppressed by presaturation) eliminated lipid resonances from 1H spectra of RIF-1 and decreased lipid contamination in spectra of EMT6/SF; however, spectral sensitivity was substantially reduced.	Water	41-46	replication timing regulatory factor 1	Mus musculus	123-128
1381588-1	1992	Ozone is shown to react with lysozyme in reverse micelles formed by 0.1 M sodium di-2-ethylhexylsulfosuccinate and 1.2-3 M water (pH 7.4) in isooctane solvent.	Water	123-128	lysozyme	Homo sapiens	29-37
1510932-0	1992	Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein.	Water	29-34	aquaporin 1 (Colton blood group)	Homo sapiens	86-92
1510956-1	1992	Water proton nuclear magnetic resonance (NMR) relaxation rates were used to identify metal sites on protein kinase C (PKC) isozymes alpha and beta using paramagnetic Gd3+ as a probe.	Water	0-5	protein kinase C alpha	Homo sapiens	118-121
1510956-2	1992	The paramagnetic effect of Gd3+ on water proton relaxation was enhanced with PKC isozymes alpha and beta in the presence of diheptanoylphosphatidylcholine/1,2-dioleoyl-sn-glycerol (PC7/DO).	Water	35-40	protein kinase C alpha	Homo sapiens	77-80
1510932-7	1992	The magnitude of CHIP28-mediated water flux (11.7 x 10(-14) cm3/s per CHIP28) corresponds to the known Pf of intact RBCs.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	17-23
1510956-2	1992	The paramagnetic effect of Gd3+ on water proton relaxation was enhanced with PKC isozymes alpha and beta in the presence of diheptanoylphosphatidylcholine/1,2-dioleoyl-sn-glycerol (PC7/DO).	Water	35-40	proprotein convertase subtilisin/kexin type 7	Homo sapiens	181-184
1510956-4	1992	Titration with Ca2+ abolished the observed enhancement of water proton relaxation by the PKC alpha.Gd3+ complex, consistent with displacement of Gd3+ by Ca2+.	Water	58-63	protein kinase C alpha	Homo sapiens	89-98
1510932-7	1992	The magnitude of CHIP28-mediated water flux (11.7 x 10(-14) cm3/s per CHIP28) corresponds to the known Pf of intact RBCs.	Water	33-38	aquaporin 1 (Colton blood group)	Homo sapiens	70-76
1510956-5	1992	Titrations of the PKC alpha.Gd3+ complex with Co(NH3)4ATP, a substitution-inert analogue of ATP, caused a substantial decrease in the observed water proton relaxation enhancement, consistent with formation of a ternary enzyme.metal.substrate complex with a KPKC alpha.Gd.	Water	143-148	protein kinase C alpha	Homo sapiens	18-27
1510932-8	1992	These results demonstrate that CHIP28 protein functions as a molecular water channel and also indicate that CHIP28 is responsible for most transmembrane water movement in RBCs.	Water	71-76	aquaporin 1 (Colton blood group)	Homo sapiens	31-37
1510932-8	1992	These results demonstrate that CHIP28 protein functions as a molecular water channel and also indicate that CHIP28 is responsible for most transmembrane water movement in RBCs.	Water	71-76	aquaporin 1 (Colton blood group)	Homo sapiens	108-114
1510932-8	1992	These results demonstrate that CHIP28 protein functions as a molecular water channel and also indicate that CHIP28 is responsible for most transmembrane water movement in RBCs.	Water	153-158	aquaporin 1 (Colton blood group)	Homo sapiens	31-37
1510932-8	1992	These results demonstrate that CHIP28 protein functions as a molecular water channel and also indicate that CHIP28 is responsible for most transmembrane water movement in RBCs.	Water	153-158	aquaporin 1 (Colton blood group)	Homo sapiens	108-114
1497021-7	1992	Oral water loading studies revealed normal urinary diluting ability and appropriate suppression of plasma vasopressin concentrations.	Water	5-10	arginine vasopressin	Homo sapiens	106-117
1324603-2	1992	For example, in the kidney, prostaglandin (PG) E2 synthesized by collecting tubule epithelia in response to arginine vasopressin (AVP) acts on the parent collecting tubule as well as the neighboring thick limb to modulate NaCl and water reabsorption occurring in response to AVP.	Water	231-236	arginine vasopressin	Homo sapiens	117-128
1400058-0	1992	Vasopressin inhibits diuresis induced by water immersion in humans.	Water	41-46	arginine vasopressin	Homo sapiens	0-11
1400058-1	1992	We tested the hypothesis that 1-desamino-8-D-arginine vasopressin (DDAVP), a V2-receptor agonist, could inhibit the diuresis induced by water immersion in humans.	Water	136-141	arginine vasopressin	Homo sapiens	54-65
1422154-10	1992	Under the conditions studied, residues 17-38 in human big endothelin-1 in water at pH 3.0 between 20-30 degrees C appear to be represented by a series of conformers in dynamic equilibrium.	Water	74-79	endothelin 1	Homo sapiens	58-70
1619653-0	1992	A 500 ps molecular dynamics simulation study of interleukin-1 beta in water.	Water	70-75	interleukin 1 beta	Homo sapiens	48-66
1322428-1	1992	Atrial natriuretic peptide (ANP) has been shown to affect water and ion transport and specific ANP binding has been identified in several secretory tissues.	Water	58-63	natriuretic peptide A	Homo sapiens	0-26
1436630-2	1992	Morphine was self-administered orally in tap water by the rats.	Water	45-50	nuclear RNA export factor 1	Rattus norvegicus	41-44
1627659-1	1992	Addition of calpain II (EC 3.4.22.17) to soluble proteins from 10-day-old rat lens caused an increase in turbidity and production of water-insoluble protein.	Water	133-138	calpain 2	Rattus norvegicus	12-22
1426981-1	1992	Vasopressin and its synthetic analogs were studied for their effect on transepithelial water flux in frog urinary bladder.	Water	87-92	arginine vasopressin	Homo sapiens	0-11
1426981-2	1992	As compared with AVP, 1-deamino-8-D-arginine vasopressin (dDAVP) was about 40 times less effective in stimulating osmotic water flow.	Water	122-127	arginine vasopressin	Homo sapiens	45-56
1426981-4	1992	Any of the above analogs did not influence basal, but antagonized vasopressin-stimulated water flux.	Water	89-94	arginine vasopressin	Homo sapiens	66-77
1322428-1	1992	Atrial natriuretic peptide (ANP) has been shown to affect water and ion transport and specific ANP binding has been identified in several secretory tissues.	Water	58-63	natriuretic peptide A	Homo sapiens	28-31
1322428-10	1992	We propose that ANP may affect local salt and water metabolism, may be involved in the secretory evolution of glandular and stromal cells, and may further facilitate endometrial development via modulation of local vascular tone and endothelial permeability.	Water	46-51	natriuretic peptide A	Homo sapiens	16-19
1402780-0	1992	Role of atrial natriuretic factor in salt and water homeostasis.	Water	46-51	natriuretic peptide A	Homo sapiens	8-33
1402780-1	1992	Studies over the past 10 years suggest that the atrial natriuretic factor (ANF) plays an important role in salt and water homeostasis.	Water	116-121	natriuretic peptide A	Homo sapiens	48-73
1402780-1	1992	Studies over the past 10 years suggest that the atrial natriuretic factor (ANF) plays an important role in salt and water homeostasis.	Water	116-121	natriuretic peptide A	Homo sapiens	75-78
1357215-2	1992	The gastric ir-somatostatin concentrations in the group treated with 0.01% ammonia (pH 9.6) for four weeks were significantly higher than those in both the group treated with 0.1% ammonia (pH 10.4), 0.1 mM-NaOH (pH 9.6), or distilled water (pH 7.0) for four weeks and the group treated with 0.01% ammonia for two weeks.	Water	234-239	somatostatin	Rattus norvegicus	15-27
1641760-0	1992	Growth hormone attenuates the abnormal distribution of body water in critically ill surgical patients.	Water	60-65	growth hormone 1	Homo sapiens	0-14
1619653-2	1992	We report the results of a 500 ps molecular dynamics simulation of the cytokine interleukin-1 beta, a protein of 153 amino acids, immersed in a sphere of 3783 bulk water molecules with a radius of 33 A.	Water	164-169	interleukin 1 beta	Homo sapiens	80-98
1636745-6	1992	1) IP endosomes labeled 10 min after ADH withdrawal (ADH IP) represented a highly purified population of WCV with high water permeability (Pf) that exhibited a low-activation energy and sensitivity to organic mercurials.	Water	119-124	arginine vasopressin	Homo sapiens	53-56
1379002-1	1992	Antidiuretic hormone (ADH) increases the osmotic water permeability (Pf) of the toad urinary bladder by insertion of water channels into the apical cell membrane.	Water	49-54	arginine vasopressin	Homo sapiens	0-20
1379002-1	1992	Antidiuretic hormone (ADH) increases the osmotic water permeability (Pf) of the toad urinary bladder by insertion of water channels into the apical cell membrane.	Water	49-54	arginine vasopressin	Homo sapiens	22-25
1379002-1	1992	Antidiuretic hormone (ADH) increases the osmotic water permeability (Pf) of the toad urinary bladder by insertion of water channels into the apical cell membrane.	Water	117-122	arginine vasopressin	Homo sapiens	0-20
1379002-1	1992	Antidiuretic hormone (ADH) increases the osmotic water permeability (Pf) of the toad urinary bladder by insertion of water channels into the apical cell membrane.	Water	117-122	arginine vasopressin	Homo sapiens	22-25
1322053-1	1992	Previous data suggest that atrial natriuretic factor (ANF) and bradykinin (BK) interact to increase Na+ and water excretion.	Water	108-113	natriuretic peptide A	Homo sapiens	27-52
1636745-10	1992	4) High permeability to protons (PH+) was seen in ADH IP endosomes but not the other fractions, providing strong evidence that the ADH water channel conducts protons.	Water	135-140	arginine vasopressin	Homo sapiens	50-53
1322053-1	1992	Previous data suggest that atrial natriuretic factor (ANF) and bradykinin (BK) interact to increase Na+ and water excretion.	Water	108-113	natriuretic peptide A	Homo sapiens	54-57
1322053-1	1992	Previous data suggest that atrial natriuretic factor (ANF) and bradykinin (BK) interact to increase Na+ and water excretion.	Water	108-113	kininogen 1	Homo sapiens	63-73
1636745-10	1992	4) High permeability to protons (PH+) was seen in ADH IP endosomes but not the other fractions, providing strong evidence that the ADH water channel conducts protons.	Water	135-140	arginine vasopressin	Homo sapiens	131-134
1322053-1	1992	Previous data suggest that atrial natriuretic factor (ANF) and bradykinin (BK) interact to increase Na+ and water excretion.	Water	108-113	kininogen 1	Homo sapiens	75-77
1382517-1	1992	The molecular structure of plasma and erythrocyte selenium-dependent glutathione peroxidase (GSH-Px) was studied in rats drinking water containing [75Se]selenious acid, 1.3 mg Se/L.	Water	130-135	glutathione peroxidase 1	Rattus norvegicus	93-99
1333234-9	1992	The bimane-modified lysine-13 protein, and to a lesser extent that modified at lysine 8, show the interesting effect of enhanced complex formation with cytochrome c oxidase when subjected to pressure, possibly because of entrapment of water at the newly created interface of the complex.	Water	235-240	cytochrome c, somatic	Homo sapiens	152-164
1437709-6	1992	Mantyl-bradykinin had excitation and fluorescence maxima at 350 nm and 426 nm in water and water/acetonitrile (ACN)/trifluoroacetic acid (TFA) solvent mixtures, respectively.	Water	81-86	kininogen 1	Homo sapiens	7-17
1525481-1	1992	We previously reported that HgCl2 inhibits water and urea flux in tissues fixed with glutaraldehyde after antidiuretic hormone (ADH) stimulation and suggested that the ADH-induced water channel may share characteristics of the red blood cell and proximal tubule water transport pathway.	Water	43-48	arginine vasopressin	Homo sapiens	168-171
1525481-1	1992	We previously reported that HgCl2 inhibits water and urea flux in tissues fixed with glutaraldehyde after antidiuretic hormone (ADH) stimulation and suggested that the ADH-induced water channel may share characteristics of the red blood cell and proximal tubule water transport pathway.	Water	180-185	arginine vasopressin	Homo sapiens	128-131
1525481-1	1992	We previously reported that HgCl2 inhibits water and urea flux in tissues fixed with glutaraldehyde after antidiuretic hormone (ADH) stimulation and suggested that the ADH-induced water channel may share characteristics of the red blood cell and proximal tubule water transport pathway.	Water	180-185	arginine vasopressin	Homo sapiens	168-171
1525481-1	1992	We previously reported that HgCl2 inhibits water and urea flux in tissues fixed with glutaraldehyde after antidiuretic hormone (ADH) stimulation and suggested that the ADH-induced water channel may share characteristics of the red blood cell and proximal tubule water transport pathway.	Water	180-185	arginine vasopressin	Homo sapiens	128-131
1525481-1	1992	We previously reported that HgCl2 inhibits water and urea flux in tissues fixed with glutaraldehyde after antidiuretic hormone (ADH) stimulation and suggested that the ADH-induced water channel may share characteristics of the red blood cell and proximal tubule water transport pathway.	Water	180-185	arginine vasopressin	Homo sapiens	168-171
1525481-3	1992	In tissues fixed after ADH stimulation, water flow and urea and sucrose permeabilities are maintained from mucosal bath pH 2.5 through pH 12.	Water	40-45	arginine vasopressin	Homo sapiens	23-26
1286691-1	1992	The experiments have been carried out on four intact awake dogs to study the influence of intragastric introduction of deionized water, 5 mmol/l of calcium and magnesium chloride solutions in a dose of 3 ml/kg on release of gastrin and insulin into blood.	Water	129-134	gastrin	Canis lupus familiaris	224-231
1286691-2	1992	It is stated that during the first 4 min after infusion of deionized water the release of gastrin decreases by 89 +/- 32 conventional units (c.u.	Water	69-74	gastrin	Canis lupus familiaris	90-97
1437997-1	1992	The Syntex adjuvant formulation (SAF) containing [thr1]-muramyldipeptide in an oil-in-water emulsion has proven to be an effective adjuvant eliciting both cell-mediated and humoral immune response.	Water	86-91	FAS antisense RNA 1	Homo sapiens	4-37
1352879-5	1992	We now report the design and synthesis of a small molecule (M(r) 810, as its trifluoroacetate salt), water soluble, proteolytically stable mimetic of residues Gln40-Thr45 of the complementarity-determining 2-like region of CD4.	Water	101-106	CD4 molecule	Homo sapiens	223-226
1437709-6	1992	Mantyl-bradykinin had excitation and fluorescence maxima at 350 nm and 426 nm in water and water/acetonitrile (ACN)/trifluoroacetic acid (TFA) solvent mixtures, respectively.	Water	91-96	kininogen 1	Homo sapiens	7-17
10045744-0	1992	Water adsorption on (111) surfaces of BaF2 and CaF2.	Water	0-5	BANF family member 2	Homo sapiens	38-42
1320335-0	1992	Kinetics of urea and water permeability activation by vasopressin in rat terminal IMCD.	Water	21-26	arginine vasopressin	Rattus norvegicus	54-65
1320335-2	1992	To assess whether these transporters may be activated by common mechanisms, we investigated the time course of increase of urea and water permeability in response to vasopressin in isolated perfused terminal IMCD segments.	Water	132-137	arginine vasopressin	Rattus norvegicus	166-177
1385963-4	1992	Water loading increased ANP levels in EH-I patients (P less than .001) and caused less marked increases of ANP in control and EH-II women and men.	Water	0-5	natriuretic peptide A	Homo sapiens	24-27
1385963-4	1992	Water loading increased ANP levels in EH-I patients (P less than .001) and caused less marked increases of ANP in control and EH-II women and men.	Water	0-5	natriuretic peptide A	Homo sapiens	107-110
1385963-7	1992	The role of ANP and DLF in hypertension are likely to be compensatory and directed against water-electrolyte metabolism disorders associated with elevated arterial pressure.	Water	91-96	natriuretic peptide A	Homo sapiens	12-15
1320335-6	1992	The lag periods between vasopressin addition and the initial rise in permeability were the same for urea (34.2 +/- 8.8 s) and water (34.8 +/- 8.9 s) transport activation.	Water	126-131	arginine vasopressin	Rattus norvegicus	24-35
1320335-9	1992	The results are consistent with the view that the rate-limiting step in vasopressin-induced activation is the same for both the urea carrier and water channel and may lie at a step beyond generation of adenosine 3",5"-cyclic monophosphate.	Water	145-150	arginine vasopressin	Rattus norvegicus	72-83
1500553-4	1992	Daily milk yield (range 16 to 52 kg/d) was related linearly to water consumption (.60 L/kg of milk), and season effect in lactating cows was curvilinear; peak water intake was in late June and nadir in late December.	Water	63-68	Weaning weight-maternal milk	Bos taurus	6-10
1396230-0	1992	Effect of atrial natriuretic factor (ANF) on water homeostasis of the neonate.	Water	45-50	natriuretic peptide A	Homo sapiens	10-35
1396230-0	1992	Effect of atrial natriuretic factor (ANF) on water homeostasis of the neonate.	Water	45-50	natriuretic peptide A	Homo sapiens	37-40
1396230-5	1992	As a result, ANF may be released to control the extracellular volume and may have a role in the complex mechanisms that regulate the water homeostasis in neonates.	Water	133-138	natriuretic peptide A	Homo sapiens	13-16
1498275-5	1992	With the osmotic gradient oriented as predicted by the model (lumen greater than bath), vasopressin increased the osmotic water permeability from 286 to 852 microns/s.	Water	122-127	arginine vasopressin	Rattus norvegicus	88-99
1498275-6	1992	Three additional series of experiments confirmed the high water permeability in the presence of vasopressin.	Water	58-63	arginine vasopressin	Rattus norvegicus	96-107
1354583-8	1992	Oxytocin, which is chemically related to the antidiuretic hormone vasopressin, influences the water metabolism in protozoa; vasopressin develops a similar effect after imprinting.	Water	94-99	arginine vasopressin	Homo sapiens	66-77
1500553-4	1992	Daily milk yield (range 16 to 52 kg/d) was related linearly to water consumption (.60 L/kg of milk), and season effect in lactating cows was curvilinear; peak water intake was in late June and nadir in late December.	Water	63-68	Weaning weight-maternal milk	Bos taurus	94-98
1434117-6	1992	A 1% NaCl solution was given as drinking water to the second group (control-saline), while tap water was given to the third group (control-water).	Water	95-100	nuclear RNA export factor 1	Rattus norvegicus	91-94
1351096-12	1992	Clonidine on the other hand increases free water clearance and this effect is mediated through an interaction with the renal actions of vasopressin.	Water	43-48	arginine vasopressin	Rattus norvegicus	136-147
1385832-1	1992	Water immersion to the neck is able to provoke a profound suppression of the renin-angiotensin system in several clinical conditions associated with hyper-reninaemia.	Water	0-5	renin	Homo sapiens	77-82
1434117-6	1992	A 1% NaCl solution was given as drinking water to the second group (control-saline), while tap water was given to the third group (control-water).	Water	95-100	nuclear RNA export factor 1	Rattus norvegicus	91-94
1386466-0	1992	Intracerebroventricular administration of a specific IL-1 receptor antagonist blocks food and water intake suppression induced by interleukin-1 beta.	Water	94-99	interleukin 1 beta	Rattus norvegicus	130-148
1386466-1	1992	Intracerebroventricular (ICV) microinfusion of recombinant human interleukin-1 beta (rhIL-1 beta, 1.0 ng/rat) suppressed the short-term (2 h) food and water intakes in rats.	Water	151-156	interleukin 1 beta	Homo sapiens	65-83
1614946-0	1992	Response to angiotensin II after selective lesioning of brain regions believed to be involved in water intake regulation.	Water	97-102	angiotensinogen	Homo sapiens	12-26
1641429-1	1992	Decrease in water intake after intraperitoneal injection of interleukin-1 beta (IL-1 beta) was studied in the rat.	Water	12-17	interleukin 1 beta	Rattus norvegicus	60-78
1641429-1	1992	Decrease in water intake after intraperitoneal injection of interleukin-1 beta (IL-1 beta) was studied in the rat.	Water	12-17	interleukin 1 beta	Rattus norvegicus	80-89
1641429-3	1992	Interleukin-1 beta also decreased spontaneous intake of water but not that of 1.8% saline.	Water	56-61	interleukin 1 beta	Rattus norvegicus	0-18
1641429-4	1992	The results suggest that the decrease in water intake by IL-1 beta is caused, at least in part, by suppression of osmotic thirst but not by general suppression of behavior.	Water	41-46	interleukin 1 beta	Rattus norvegicus	57-66
1641429-6	1992	Pretreatment with indomethacin blocked the decrease in water intake by IL-1 beta, suggesting the involvement of production of prostaglandins.	Water	55-60	interleukin 1 beta	Rattus norvegicus	71-80
1614946-9	1992	Feed intake was suppressed and water intake increased by ANGII injection.	Water	31-36	angiotensinogen	Homo sapiens	57-62
1614946-10	1992	The present study indicates that the SFO, but not the OVLT, plays a role in ANGII-induced water intake in broiler chicks.	Water	90-95	angiotensinogen	Homo sapiens	76-81
1534149-1	1992	Antidiuresis, the recovery of water from the lumen of the renal collecting tubule, is regulated by the hypothalamic release of antidiuretic hormone (ADH), which binds to specific receptors on renal collecting tubule cells, stimulates adenylyl cyclase and promotes the cyclic AMP-mediated incorporation of water pores into the luminal surface of these cells.	Water	30-35	arginine vasopressin	Homo sapiens	127-147
1534149-1	1992	Antidiuresis, the recovery of water from the lumen of the renal collecting tubule, is regulated by the hypothalamic release of antidiuretic hormone (ADH), which binds to specific receptors on renal collecting tubule cells, stimulates adenylyl cyclase and promotes the cyclic AMP-mediated incorporation of water pores into the luminal surface of these cells.	Water	30-35	arginine vasopressin	Homo sapiens	149-152
1534149-1	1992	Antidiuresis, the recovery of water from the lumen of the renal collecting tubule, is regulated by the hypothalamic release of antidiuretic hormone (ADH), which binds to specific receptors on renal collecting tubule cells, stimulates adenylyl cyclase and promotes the cyclic AMP-mediated incorporation of water pores into the luminal surface of these cells.	Water	305-310	arginine vasopressin	Homo sapiens	127-147
1534149-1	1992	Antidiuresis, the recovery of water from the lumen of the renal collecting tubule, is regulated by the hypothalamic release of antidiuretic hormone (ADH), which binds to specific receptors on renal collecting tubule cells, stimulates adenylyl cyclase and promotes the cyclic AMP-mediated incorporation of water pores into the luminal surface of these cells.	Water	305-310	arginine vasopressin	Homo sapiens	149-152
1577711-8	1992	These results demonstrate that at least one intracellular mammalian phospholipase A2 employs a catalytic strategy distinct from that utilized by extracellular phospholipases A2 (i.e. formation of an acyl-enzyme intermediate by nucleophilic attack versus activation of a water molecule) and that arachidonic acid in endogenous phospholipid storage depots can, in principle, be sequentially transferred through an acyl-enzyme intermediate without the prior obligatory release of free arachidonic acid.	Water	270-275	phospholipase A2 group IB	Homo sapiens	68-84
1316150-5	1992	An "S3"-type signal and YZ+ were also formed in PS2 samples treated with the water analogue ammonia.	Water	77-82	taste 2 receptor member 64 pseudogene	Homo sapiens	48-51
1599508-3	1992	Purified rabbit liver aldehyde oxidase readily reduced azo dyes which are mainly water soluble and contain charged groups.	Water	81-86	aldehyde oxidase 1	Homo sapiens	22-38
1534205-4	1992	Atrial natriuretic peptide concentration was higher (P less than 0.05) and plasma renin activity was lower (P less than 0.05) in water than on land at 40% peak VO2 through minute 5 of recovery.	Water	129-134	renin	Homo sapiens	82-87
1576035-4	1992	There are numerous pathologic and iatrogenic causes for water imbalance, the most troublesome being disorders of antidiuretic hormone (ADH) secretion.	Water	56-61	arginine vasopressin	Homo sapiens	113-133
1576035-5	1992	Antidiuretic hormone plays a pivotal role in conserving water by increasing reabsorption of water by the kidney.	Water	56-61	arginine vasopressin	Homo sapiens	0-20
1576035-5	1992	Antidiuretic hormone plays a pivotal role in conserving water by increasing reabsorption of water by the kidney.	Water	92-97	arginine vasopressin	Homo sapiens	0-20
1577735-0	1992	Adsorption of apolipoprotein A-IV to phospholipid monolayers spread at the air/water interface.	Water	79-84	apolipoprotein A4	Homo sapiens	14-33
1577735-3	1992	We therefore used a surface balance and surface radioactivity detector to investigate the adsorption of apoA-IV to egg phosphatidylcholine monolayers spread at the air/water interface.	Water	168-173	apolipoprotein A4	Homo sapiens	104-111
1534205-5	1992	Plasma aldosterone and arginine vasopressin concentrations were lower (P less than 0.05) in water at peak exercise and at minutes 1 and 5 of recovery.	Water	92-97	arginine vasopressin	Homo sapiens	32-43
1449564-3	1992	To somewhat increase plasma ANF level, the subjects were slightly loaded with water before the trial.	Water	78-83	natriuretic peptide A	Homo sapiens	28-31
1318095-0	1992	Regulation of water flow by actin-binding protein-induced actin gelatin.	Water	14-19	sex hormone binding globulin	Homo sapiens	28-49
1318095-9	1992	These effects depend on actin filament immobilization, because the ABP concentration that causes initial impairment of water flow by actin filaments corresponds to the gel point measured viscometrically and because gelsolin, which noncovalently severs actin filaments, solates actin gels and restores water flow in a solution of actin cross-linked by ABP.	Water	119-124	sex hormone binding globulin	Homo sapiens	67-70
1318095-9	1992	These effects depend on actin filament immobilization, because the ABP concentration that causes initial impairment of water flow by actin filaments corresponds to the gel point measured viscometrically and because gelsolin, which noncovalently severs actin filaments, solates actin gels and restores water flow in a solution of actin cross-linked by ABP.	Water	301-306	sex hormone binding globulin	Homo sapiens	67-70
1314853-4	1992	Intravenous infusion (60 min) of recombinant human IL-2 at 10(5)-10(6) U/rat (n = 7-9) dose-dependently elevated lung water content (27 +/- 1%, P less than 0.01), myeloperoxidase activity (+84 +/- 23%, P less than 0.05), and serum thromboxane B2 (990 +/- 70%, P less than 0.01), but failed to alter blood pressure, hematocrit, serum tumor necrosis factor-alpha, and circulating leukocytes and platelets.	Water	118-123	interleukin 2	Homo sapiens	51-55
1535825-2	1992	infusion (20 micrograms/h) over 3 h) of human alpha-atrial natriuretic peptide (ANP) on Na and water intake of sheep was studied.	Water	95-100	natriuretic peptide A	Homo sapiens	46-78
1535825-2	1992	infusion (20 micrograms/h) over 3 h) of human alpha-atrial natriuretic peptide (ANP) on Na and water intake of sheep was studied.	Water	95-100	natriuretic peptide A	Homo sapiens	80-83
1567910-2	1992	The interaction of pancreatic phospholipase A2 with micellar lipid/water interfaces of competitive inhibitors.	Water	67-72	phospholipase A2 group IB	Homo sapiens	30-46
1613430-4	1992	The ratio of plasma oxytocin:vasopressin reached a significant peak at about 02.00 h which might be related to the feeding activity of the rats, food and water intake being largely confined to the night, as was fluid excretion.	Water	154-159	arginine vasopressin	Rattus norvegicus	29-40
1328796-9	1992	of 1.58 +/- 0.13 X 10(9) M-1 s-1 and 1.88 +/- 0.14 X 10(9) M-1 s-1 was measured in the Fenton model and in the water radiolysis system, respectively.	Water	111-116	myoregulin	Homo sapiens	25-38
1441548-7	1992	The most important biological function of decidual prolactin is its effect on water and electrolyte transport for the needs of the fetus, and this transport takes place mainly across the fetal membranes.	Water	78-83	prolactin	Homo sapiens	51-60
1572354-7	1992	The expression of lactate dehydrogenase activity in the low-water system was higher with the heart than with the muscle enzyme compared to their activities in all-water media (about 260 and 600 mumol min-1 mg-1 in the heart and muscle enzymes respectively).	Water	60-65	CD59 molecule (CD59 blood group)	Homo sapiens	200-210
1507935-3	1992	Patients with heart failure may exhibit hyponatremia due to a decrease in water excretion, which may be related to the enhanced release of both angiotensin and vasopressin and can be exaggerated by diuretic therapy.	Water	74-79	arginine vasopressin	Homo sapiens	160-171
1567910-12	1992	The modified PLA2 still adsorbs to micellar lipid/water interfaces but cannot bind either of the two enantiomers into its active site and similar dissociation constants were found for lipid-protein complexes with micelles of either the (R) or the (S) inhibitors.	Water	50-55	phospholipase A2 group IB	Homo sapiens	13-17
1515929-6	1992	These results demonstrate that centrally administered ANG II and ANG III increase both water intake and blood pressure via the AT1 receptor subtype.	Water	87-92	angiotensinogen	Rattus norvegicus	54-60
1387020-6	1992	OPC-31260 at doses of 10 to 100 micrograms kg-1, i.v., inhibited the antidiuretic action of exogenously administered AVP in water-loaded, alcohol-anaesthetized rats in a dose-dependent manner.	Water	124-129	arginine vasopressin	Rattus norvegicus	117-120
1533821-3	1992	In the volume-expanded state, ANF was almost twice as high (p less than 0.025) in diabetic-uremics than in control uremics (152 +/- 29 vs 84 +/- 10 pg/ml) in the face of similar right atrial pressure (14 +/- 3 vs 12 +/- 1 cm H2O).	Water	225-228	natriuretic peptide A	Homo sapiens	30-33
1617435-5	1992	In 11 of these 33 regions, ingestion of a small amount of water was associated with a reversal of AII-induced elevation in blood flow [i.e., AII (W+) less than AII (W-)]; these regions included the organum vasculosum lamina terminalis, rostral lateral hypothalamus, supraoptic nuclei, rostral zona incerta, and median eminence.	Water	58-63	angiotensinogen	Rattus norvegicus	98-101
1617435-5	1992	In 11 of these 33 regions, ingestion of a small amount of water was associated with a reversal of AII-induced elevation in blood flow [i.e., AII (W+) less than AII (W-)]; these regions included the organum vasculosum lamina terminalis, rostral lateral hypothalamus, supraoptic nuclei, rostral zona incerta, and median eminence.	Water	58-63	angiotensinogen	Rattus norvegicus	141-144
1617435-5	1992	In 11 of these 33 regions, ingestion of a small amount of water was associated with a reversal of AII-induced elevation in blood flow [i.e., AII (W+) less than AII (W-)]; these regions included the organum vasculosum lamina terminalis, rostral lateral hypothalamus, supraoptic nuclei, rostral zona incerta, and median eminence.	Water	58-63	angiotensinogen	Rattus norvegicus	141-144
1516268-4	1992	The effects of AII on water and electrolyte transport are biphasic and dose-dependent, such that low concentrations (10(-12)-10(-9) mol/L) stimulate reabsorption whereas high concentrations (10(-7)-10(-6) mol/L) inhibit reabsorption.	Water	22-27	angiotensinogen	Homo sapiens	15-18
1594678-6	1992	Electrolytic lesions of rACE produced a very profound PA deficit and also blocked the rapid development of gastric erosions by water-restraint stress, effects that were not found with ibotenate lesions in this location.	Water	127-132	angiotensin I converting enzyme	Rattus norvegicus	24-28
1516268-2	1992	Independent of its effects on renal haemodynamics and glomerular filtration, angiotensin II (AII) has direct actions on the proximal tubule involving transepithelial Na+, H+, HCO3-, and water reabsorption, ammoniagenesis, gluconeogenesis and renal growth.	Water	186-191	angiotensinogen	Homo sapiens	77-91
1516268-2	1992	Independent of its effects on renal haemodynamics and glomerular filtration, angiotensin II (AII) has direct actions on the proximal tubule involving transepithelial Na+, H+, HCO3-, and water reabsorption, ammoniagenesis, gluconeogenesis and renal growth.	Water	186-191	angiotensinogen	Homo sapiens	93-96
1618742-2	1992	The lipoprotein lipase retained tributyrin, water-soluble substrate, hydrolyzing activity (esterase activity).	Water	44-49	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	4-22
1527475-6	1992	When human HDL was delipidated, the trypanocidal activity was associated with the water-soluble protein (apolipoprotein) fraction and not with the lipid constituents.	Water	82-87	apolipoprotein E	Homo sapiens	105-119
1557381-2	1992	A prime experimental method of identifying H-2 odortypes is the specially designed Y-maze in which mice are trained, by water deprivation and reward, to distinguish odors conducted to the arms of the maze from H-2-dissimilar mice or their urines.	Water	120-125	histocompatibility-2, MHC	Mus musculus	43-46
1377630-7	1992	substance P (measured as peak increases in lung resistance in cm H2O/ml per s) at 6 h following antigen was noted in the presence of IL-1ra (30 mg/kg i.p.).	Water	65-68	tachykinin precursor 1	Homo sapiens	0-11
1442451-5	1992	Water-induced bronchoconstriction improved in 66% of LIT group (4/6) compared with none of SIT group (0/4).	Water	0-5	TNF receptor superfamily member 10c	Homo sapiens	53-56
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	Water	161-166	interleukin 1 beta	Homo sapiens	18-36
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	Water	161-166	interleukin 1 beta	Homo sapiens	40-49
1735647-3	1992	Results showed a uranium concentration in drinking water of 0.67-20.26 micrograms L-1.	Water	51-56	immunoglobulin kappa variable 1-16	Homo sapiens	82-85
1533481-0	1992	Plasma vasopressin and atrial natriuretic hormone levels in hypopituitarism with and without hydrocortisone treatments: responses to an acute water load.	Water	142-147	arginine vasopressin	Homo sapiens	7-18
1533481-5	1992	These results demonstrate that the impaired arginine vasopressin response to acute water loading play an essential role in deranged renal water and electrolyte handling in the state of glucocorticoid deficiency; the impaired release of atrial natriuretic hormone also may affect these disorders.	Water	83-88	arginine vasopressin	Homo sapiens	53-64
1533481-5	1992	These results demonstrate that the impaired arginine vasopressin response to acute water loading play an essential role in deranged renal water and electrolyte handling in the state of glucocorticoid deficiency; the impaired release of atrial natriuretic hormone also may affect these disorders.	Water	138-143	arginine vasopressin	Homo sapiens	53-64
1312459-9	1992	These findings suggest that loss of water not only from periventricular white matter but also from cortex is the main etiological factor of brain shrinkage induced by ACTH.	Water	36-41	proopiomelanocortin	Homo sapiens	167-171
1627273-8	1992	The SOD mimetic activity of PS-K resisted treatment by 0.7N HCl, 0.7N NaOH, boiling for 30 minutes in a double water bath, and digestion by pronase.	Water	111-116	superoxide dismutase 1	Homo sapiens	4-7
1571785-6	1992	NPY injections into PVN increased food and water consumption in both young and aged satiated rats 30, 90 and 240 min after injection.	Water	43-48	neuropeptide Y	Rattus norvegicus	0-3
1324077-1	1992	The magnocellular hypothalamo-neurohypophysial system is, via a release of vasopressin from nerve terminals in the neurohypophysis to the peripheral blood, centrally involved in the regulation of body salt and water homeostasis.	Water	210-215	arginine vasopressin	Rattus norvegicus	75-86
1581643-1	1992	The features of the far UV CD spectrum of endothelin 1 (ET 1) in water-containing solutions rules out the presence of any alpha-helical contribution, thus questioning the conclusions made by several authors on the basis of NMR investigations.	Water	65-70	endothelin 1	Homo sapiens	42-54
1581643-1	1992	The features of the far UV CD spectrum of endothelin 1 (ET 1) in water-containing solutions rules out the presence of any alpha-helical contribution, thus questioning the conclusions made by several authors on the basis of NMR investigations.	Water	65-70	endothelin 1	Homo sapiens	56-60
1324077-8	1992	This raises evidence that NPY containing hypothalamo-neurohypophysial neurons as well as peripherally released NPY may be involved in the regulation of water homeostasis via NPY receptors in the neurohypophysis.	Water	152-157	neuropeptide Y	Rattus norvegicus	26-29
1324077-8	1992	This raises evidence that NPY containing hypothalamo-neurohypophysial neurons as well as peripherally released NPY may be involved in the regulation of water homeostasis via NPY receptors in the neurohypophysis.	Water	152-157	neuropeptide Y	Rattus norvegicus	111-114
1324077-8	1992	This raises evidence that NPY containing hypothalamo-neurohypophysial neurons as well as peripherally released NPY may be involved in the regulation of water homeostasis via NPY receptors in the neurohypophysis.	Water	152-157	neuropeptide Y	Rattus norvegicus	111-114
1310614-4	1992	The water-lipid interface induces a secondary folding of apocytochrome c, whereas cytochrome c is suggested to partially lose its tertiary structure.	Water	4-9	cytochrome c, somatic	Homo sapiens	60-72
1310614-0	1992	A water-lipid interface induces a highly dynamic folded state in apocytochrome c and cytochrome c, which may represent a common folding intermediate.	Water	2-7	cytochrome c, somatic	Homo sapiens	68-80
1736987-1	1992	The conformational features of endothelin-1 (ET-1) in mixed water/ethylene glycol media have been studied by two-dimensional 1H NMR experiments throughout the pH range 3.2-7.2.	Water	60-65	endothelin 1	Homo sapiens	31-43
1371649-1	1992	It is clearly established that the changes induced by antidiuretic hormone (ADH) in its target epithelial cells result from the insertion in the apical membrane of new components that contain channels for water.	Water	205-210	arginine vasopressin	Homo sapiens	54-74
1371649-1	1992	It is clearly established that the changes induced by antidiuretic hormone (ADH) in its target epithelial cells result from the insertion in the apical membrane of new components that contain channels for water.	Water	205-210	arginine vasopressin	Homo sapiens	76-79
1371649-4	1992	The results obtained clearly demonstrated a preferential labeling by the selected antibodies of morphological structures such as the groove arrays and the fusion images that are generally accepted as being involved in ADH-induced changes in water permeability of the apical membrane.	Water	241-246	arginine vasopressin	Homo sapiens	218-221
1596738-6	1992	Central IL-1 beta administration was also more potent than IP injection in inhibiting overnight food and water intake.	Water	105-110	interleukin 1 beta	Mus musculus	8-17
1310279-2	1992	Synthetic chicken ANF (chANF) was applied iv at doses of 10, 50, and 90 ng/min.kg BW for 10 min and caused dose-dependent transient increases in urine flow, osmolal excretion, glomerular filtration rate, effective renal plasma flow, and fractional water clearance at decreased urinary osmolality.	Water	248-253	natriuretic peptide A	Gallus gallus	18-21
1551237-1	1992	We developed a simple, kinetic method for the determination of catalase activity in which i) the enzyme catalyzes the peroxidation of ethanol by hydrogen peroxide to acetaldehyde and water, and ii) the acetaldehyde so formed is rapidly oxidized to acetic acid and NADPH by the addition of an excess of NADP+ and aldehyde dehydrogenase.	Water	183-188	catalase	Homo sapiens	63-71
1310279-5	1992	ANF-induced modulation of renal salt and water elimination via glomerular and tubular receptor interactions is consistent with the concept that this hormone has a physiological role in avian volume homeostasis.	Water	41-46	natriuretic peptide A	Homo sapiens	0-3
1373060-1	1992	A common epitope on S-antigen (arrestin), a potent autoantigen inducing experimental autoimmune uveoretinitis (EAU), and on human tumor necrosis factor alpha (hTNF alpha) was revealed using two monoclonal antibodies to S-antigen which inhibit EAU induction.	Water	111-114	tumor necrosis factor	Homo sapiens	130-157
1376798-5	1992	Expected pharmacologic effects of an ACE inhibitor were observed at all doses and included increased urine output, increased water consumption, decreased serum aldosterone (65 or 25% of control at 10 or 400 mg/kg, respectively, on day 28), increased plasma renin activity (PRA, up to two- to threefold higher than controls at day 28), and hypertrophy of the juxtaglomerular apparatus.	Water	125-130	angiotensin I converting enzyme	Rattus norvegicus	37-40
1418524-1	1992	It was demonstrated that the water extract of Pilose Antler (WEPA) showed a higher inhibitory effect on MAO-B activities in the liver and brain tissues of aged mice, but nearly no effect on NAO-A.	Water	29-34	monoamine oxidase B	Mus musculus	104-109
1311103-1	1992	The present studies examine the effect of the nonpeptide angiotensin II (AII) type 1 receptor antagonist, DuP 753, on water intake in rats treated with dipsogenic stimuli, which are thought to induce drinking via release of renin and subsequent formation of AII.	Water	118-123	angiotensinogen	Rattus norvegicus	57-71
1311103-1	1992	The present studies examine the effect of the nonpeptide angiotensin II (AII) type 1 receptor antagonist, DuP 753, on water intake in rats treated with dipsogenic stimuli, which are thought to induce drinking via release of renin and subsequent formation of AII.	Water	118-123	angiotensinogen	Rattus norvegicus	73-76
1311103-7	1992	The results are discussed in terms of the importance of AII in mediating isoproterenol-, serotonin-, and 5-hydroxytryptophan-induced water intake and suggest a need to readdress this mechanism.	Water	133-138	angiotensinogen	Rattus norvegicus	56-59
1611776-16	1992	A water-load test demonstrated failure of both water diuresis and inhibition of ADH secretion.	Water	2-7	arginine vasopressin	Homo sapiens	80-83
1737576-6	1992	PYY inhibited the reduction in net absorption of sodium chloride and water evoked by vasoactive intestinal peptide (VIP), but did not affect the VIP-evoked increase in net potassium secretion.	Water	69-74	vasoactive intestinal peptide	Rattus norvegicus	116-119
1310400-1	1992	Heavy water (D2O) has been used as a putative inhibitor of the plasma membrane H(+)-ATPase and the plasma membrane redox system.	Water	6-11	membrane H(+)-ATPase 1	Zea mays	63-90
1618259-2	1992	Angiotensin II (0.1-1.0 mg/kg s.c.) caused a dose-dependent increase in drinking in water-replete rats.	Water	84-89	angiotensinogen	Rattus norvegicus	0-14
1609649-0	1992	Bradykinin modulation of the hydroosmotic effect of the antidiuretic hormone in water-transporting epithelia.	Water	80-85	kininogen 1	Homo sapiens	0-10
1310248-4	1992	Angiotensin II, 0.25 mg/kg, reliably reduced intake of ethanol when it was presented alone during the 1st h of the daily 2-h drinking session, and reliably increased intake of water when it was subsequently presented alone during the 2nd h. Thus the reduction in intake of ethanol seen when the alcoholic beverage is presented concurrently with water is probably not merely due to the increase in intake of water.	Water	176-181	angiotensinogen	Rattus norvegicus	0-14
1310248-4	1992	Angiotensin II, 0.25 mg/kg, reliably reduced intake of ethanol when it was presented alone during the 1st h of the daily 2-h drinking session, and reliably increased intake of water when it was subsequently presented alone during the 2nd h. Thus the reduction in intake of ethanol seen when the alcoholic beverage is presented concurrently with water is probably not merely due to the increase in intake of water.	Water	345-350	angiotensinogen	Rattus norvegicus	0-14
1310248-4	1992	Angiotensin II, 0.25 mg/kg, reliably reduced intake of ethanol when it was presented alone during the 1st h of the daily 2-h drinking session, and reliably increased intake of water when it was subsequently presented alone during the 2nd h. Thus the reduction in intake of ethanol seen when the alcoholic beverage is presented concurrently with water is probably not merely due to the increase in intake of water.	Water	345-350	angiotensinogen	Rattus norvegicus	0-14
1304187-2	1992	Because PRL is thought to be involved in the regulation of brain water and electrolyte content attempt has been made to determine CSF and plasma PRL and dopamine (DA) concentrations, osmolality, and sodium level in 21 newborn infants undergoing lumbar punction because of apneic spells, fever, or perinatal asphyxia.	Water	65-70	prolactin	Homo sapiens	8-11
1609649-0	1992	Bradykinin modulation of the hydroosmotic effect of the antidiuretic hormone in water-transporting epithelia.	Water	80-85	arginine vasopressin	Homo sapiens	56-76
1609649-2	1992	Amongst them, considerable evidence suggests that the diuretic effects of endogenous bradykinin are, in part, mediated by inhibition of vasopressin-stimulated water transport.	Water	159-164	kininogen 1	Homo sapiens	85-95
1609649-2	1992	Amongst them, considerable evidence suggests that the diuretic effects of endogenous bradykinin are, in part, mediated by inhibition of vasopressin-stimulated water transport.	Water	159-164	arginine vasopressin	Homo sapiens	136-147
1316115-7	1992	With MPO-H2O2-chloride, MPO-H2O2-iodide and LPO-H2O2-iodide systems, we observed the increased degradation of EtHg in deuterium oxide (D2O) medium better than that in H2O medium.	Water	9-12	myeloperoxidase	Homo sapiens	5-8
1733292-1	1992	The brain angiotensin (ANG II and III) system is known to play an important role in the central control of cardiovascular function and body water homeostasis.	Water	140-145	angiotensinogen	Rattus norvegicus	23-37
1524247-2	1992	The study has revealed 3 types of reactions in hormones regulating water-electrolyte homeostasis: type I--a decrease in vasopressin (VP) concentration and renin-angiotensin-aldosterone system (RAAS) activity; type II--VP increase and RAAS activation; type III--an increase in VP content and RAAS disbalance.	Water	67-72	arginine vasopressin	Homo sapiens	120-131
1633072-7	1992	Activity of the renin-angiotensin system is associated with sodium and water retention and plasma volume expansion.	Water	71-76	renin	Homo sapiens	16-21
1420615-5	1992	During CPAP of 4 cm H2O, significant increases occurred in mean right atrial pressure (Pra) (2.1 +/- 0.3 to 3.3 +/- 0.4 mm Hg; p less than 0.01), left ventricular end-diastolic pressure (LVEDP) (2.8 +/- 0.4 to 3.7 +/- 0.3 mm Hg; p less than 0.01), and mean pulmonary artery pressure (Ppa) (12.9 +/- 0.8 to 15.1 +/- 0.8 mm Hg; p less than 0.01).	Water	20-23	S100 calcium binding protein A6	Homo sapiens	87-90
1420615-6	1992	CPAP of 8 cm H2O produced marked increases in Pra (2.1 +/- 0.2 to 4.9 +/- 0.7 mm Hg; p less than 0.01), LVEDP (2.7 +/- 0.5 to 4.5 +/- 0.4 mm Hg; p less than 0.01) and Ppa (12.8 +/- 0.8 to 17.7 +/- 0.6 mm Hg; p less than 0.01).	Water	13-16	S100 calcium binding protein A6	Homo sapiens	46-49
1316186-10	1992	An experiment using 17O-enriched water revealed that the Co(II)-ethylenediamine complex caused the DMPO to react with solvent water to form the DMPO/.OH adduct.	Water	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
1342827-0	1992	In vitro action of vasopressin on water absorption by rat colon.	Water	34-39	arginine vasopressin	Rattus norvegicus	19-30
1342827-2	1992	Vasopressin (10 mM) significantly stimulated water absorption in both the proximal (4.85 +/- 3.78 vs 1.51 +/- 1.16 ml/mg) and distal (10.39 +/- 3.52 vs 7.22 +/- 3.58 ml/mg) colon, which corresponds to an increase of 220% and 50%, respectively.	Water	45-50	arginine vasopressin	Rattus norvegicus	0-11
1342827-3	1992	The results indicate the need for a study of the possible physiological function of vasopressin in enhancing intestinal water absorption, when it is released in response to plasma hyperosmolarity.	Water	120-125	arginine vasopressin	Rattus norvegicus	84-95
1316186-10	1992	An experiment using 17O-enriched water revealed that the Co(II)-ethylenediamine complex caused the DMPO to react with solvent water to form the DMPO/.OH adduct.	Water	126-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
1732025-4	1992	Children needing CPR in an emergency room setting have poor outcome unless the submersion incident occurred in ice-water and the patient is hypothermic upon arrival in the emergency room.	Water	115-120	cytochrome p450 oxidoreductase	Homo sapiens	17-20
1385043-1	1992	Common epitopes on S-antigen (arrestin), a potent autoantigen inducing experimental autoimmune uveoretinitis (EAU), and on human tumor necrosis factor alpha (hTNF alpha) are revealed with monoclonal antibodies (mAb) to S-antigen, which inhibit EAU induction.	Water	110-113	tumor necrosis factor	Homo sapiens	129-156
1425651-2	1992	We tested the hypothesis that elevated plasma concentrations of vasopressin and/or aldosterone above that seen with water ingestion may explain this observation.	Water	116-121	arginine vasopressin	Homo sapiens	64-75
1385043-1	1992	Common epitopes on S-antigen (arrestin), a potent autoantigen inducing experimental autoimmune uveoretinitis (EAU), and on human tumor necrosis factor alpha (hTNF alpha) are revealed with monoclonal antibodies (mAb) to S-antigen, which inhibit EAU induction.	Water	110-113	tumor necrosis factor	Homo sapiens	158-168
1486803-1	1992	Two posterior pituitary hormones oxytocin and arginine-vasopressin control the important activities of water excretion, parturition and lactation.	Water	103-108	arginine vasopressin	Homo sapiens	55-66
15091969-3	1992	These clear water streams are low in ANC (0-70 microeq litre(-1)), with variations caused by changing concentrations of base cations, SO4, NO3 and Cl.	Water	12-17	NBL1, DAN family BMP antagonist	Homo sapiens	139-142
1592181-11	1992	Upon reconstitution of freeze-dried IFN by vigorous shaking with distilled water, filtration of the solution may become difficult because polymers might have been formed during vigorous shaking.	Water	75-80	interferon alpha 1	Homo sapiens	36-39
1360400-0	1992	[Use of bovine serum albumin conjugates with polyalkyleneoxides for studying the inhibiting effect of water-insoluble dihydroriboflavin esters].	Water	102-107	albumin	Homo sapiens	15-28
1577837-14	1992	The distribution of adsorbed fibrinogen molecules indicates that surface-adsorbed fibrinogen may form a two-phase system, containing significant amounts of water.	Water	156-161	fibrinogen beta chain	Homo sapiens	29-39
1727759-8	1992	It is concluded that intact prostaglandin synthesis is necessary for the actions of neurotensin and secretin (but not that of cholecystokinin) on pancreatic exocrine secretion of water and bicarbonate and for neurotensin- (but not cholecystokinin-) stimulated release of pancreatic polypeptide.	Water	179-184	neurotensin	Canis lupus familiaris	84-95
1577837-14	1992	The distribution of adsorbed fibrinogen molecules indicates that surface-adsorbed fibrinogen may form a two-phase system, containing significant amounts of water.	Water	156-161	fibrinogen beta chain	Homo sapiens	82-92
1338637-3	1992	There is indeed an increased number of radioresistant types of microbes with intensified activity of catalase and nuclease in pool water of atomic reactors.	Water	131-136	catalase	Homo sapiens	101-109
1382164-7	1992	A kinin induced increase in collecting duct PG synthesis may account for the water diuresis seen clinically with ACE inhibitors.	Water	77-82	angiotensin I converting enzyme	Homo sapiens	113-116
1284427-7	1992	The high water-solubility of Cbz-Arg-Leu-Val-Gly-CHN2 allowing it to be dissolved to molar concentrations without use of non-physiological additives, makes it suitable for in vitro and in vivo cysteine proteinase inhibition studies.	Water	9-14	chimerin 2	Homo sapiens	49-53
1494029-1	1992	The amphibian antidiuretic hormone, arginine vasotocin, stimulated osmotic water flow across isolated skin from the pelvic but not the pectoral skin of the toad, Bufo woodhouseii.	Water	75-80	arginine vasopressin	Homo sapiens	14-34
1436296-7	1992	In vitro measurements of 3H2O permeability of perfused IMCD of normal rats showed that vasopressin (50 microU/ml) added to the bath increased the diffusional water permeability (43.4 +/- 4.8 vs. 105.6 +/- 9.1 x 10(-5) cm/s), while in acyclovir rats, the control value (58.8 +/- 9.1 x 10(-5) cm/s) did not increase significantly in the presence of vasopressin (71.3 +/- 13.6 x 10(-5) cm/s).	Water	158-163	arginine vasopressin	Rattus norvegicus	87-98
1289564-3	1992	It was found that the activity of glutamate decarboxylase can increase by 30% in magnetized water.	Water	92-97	glutamate-ammonia ligase	Homo sapiens	34-57
1291859-6	1992	Water permeability in the presence of submaximal concentrations of AVP (20 microU/ml) was also significantly increased with lower concentrations of ethanol (0.12, 0.24 and 0.48 g%) but fell to control levels with higher concentrations.	Water	0-5	arginine vasopressin	Rattus norvegicus	67-70
1539068-2	1992	AII induced the expected abrupt increase in water intake and a more gradual increase in urine output.	Water	44-49	angiotensinogen	Rattus norvegicus	0-3
1509176-2	1992	It emphasizes the situation within the Community of European Countries by referring to limit values used in the EEC and some of its member states for emissions to water, air and soil.	Water	163-168	Ectrodactyly, ectodermal dysplasia, cleft lip/palate, 1	Homo sapiens	112-115
1410430-5	1992	Alternatively, the elevated level of blood-borne angiotensin II may well explain the higher metabolic response of the SFO following water deprivation compared to salt ingestion.	Water	132-137	angiotensinogen	Rattus norvegicus	49-63
1814758-0	1991	Enhanced sensitivity to anorexia and consumption of drinking water induced by interleukin-1 beta in obese yellow mice.	Water	61-66	interleukin 1 beta	Mus musculus	78-96
1481680-6	1992	As an example, the interaction between water-soluble vitamins--Vit B1, Vit B2, Vit C and nicotinamide was determined.	Water	39-44	vitrin	Homo sapiens	63-66
1481680-6	1992	As an example, the interaction between water-soluble vitamins--Vit B1, Vit B2, Vit C and nicotinamide was determined.	Water	39-44	vitrin	Homo sapiens	71-74
1481680-6	1992	As an example, the interaction between water-soluble vitamins--Vit B1, Vit B2, Vit C and nicotinamide was determined.	Water	39-44	vitrin	Homo sapiens	71-74
1815144-1	1991	Topical stimulation of the subfornical organ (SFO) with angiotensin II (ANG II) or acetylcholine (ACh) increased blood pressure, water intake, and the activity of the hypothalamo-neurohypophysial system (HNS).	Water	129-134	angiotensinogen	Rattus norvegicus	56-70
1815144-1	1991	Topical stimulation of the subfornical organ (SFO) with angiotensin II (ANG II) or acetylcholine (ACh) increased blood pressure, water intake, and the activity of the hypothalamo-neurohypophysial system (HNS).	Water	129-134	angiotensinogen	Rattus norvegicus	72-78
1814572-1	1991	Intake of rat chow and water was reduced 4 and 8 h after the intrahypothalamic injection of 5 ng interleukin-1a (IL-1a).	Water	23-28	interleukin 1 alpha	Rattus norvegicus	97-111
1814572-1	1991	Intake of rat chow and water was reduced 4 and 8 h after the intrahypothalamic injection of 5 ng interleukin-1a (IL-1a).	Water	23-28	interleukin 1 alpha	Rattus norvegicus	113-118
1814538-5	1991	Significant increases of daily water intake indicated impaired vasopressin release following both types of surgical transection.	Water	31-36	arginine vasopressin	Rattus norvegicus	63-74
1752966-9	1991	Our results suggest that in the setting of water deprivation, TGF-beta 2 is localized in a manner which would allow it to act either as a growth factor for or as a phenotypic modulator of the JGA and renal arterioles.	Water	43-48	transforming growth factor, beta 2	Mus musculus	62-72
1815533-8	1991	Levonorgestrel moderated water imbibition in CCl4 impairment.	Water	25-30	C-C motif chemokine ligand 4	Rattus norvegicus	45-49
1661085-0	1991	Endothelin-1 inhibits AVP-stimulated osmotic water permeability in rat inner medullary collecting duct.	Water	45-50	endothelin 1	Rattus norvegicus	0-12
1661085-0	1991	Endothelin-1 inhibits AVP-stimulated osmotic water permeability in rat inner medullary collecting duct.	Water	45-50	arginine vasopressin	Rattus norvegicus	22-25
1661085-4	1991	Endothelin, at 10(-10) and 10(-8) M, reversibly inhibited 10(-11) M arginine vasopressin (AVP)-stimulated osmotic water permeability (Pf) by 18 and 24%, respectively.	Water	114-119	arginine vasopressin	Rattus norvegicus	77-88
1661085-4	1991	Endothelin, at 10(-10) and 10(-8) M, reversibly inhibited 10(-11) M arginine vasopressin (AVP)-stimulated osmotic water permeability (Pf) by 18 and 24%, respectively.	Water	114-119	arginine vasopressin	Rattus norvegicus	90-93
1684820-6	1991	Administration of the vasopressin receptor antagonist, SK&amp;F 105494, to either dogs or cynomolgus monkeys demonstrated that antagonism of the vasopressin V2 receptor could result in a brisk water diuresis in both species.	Water	193-198	arginine vasopressin	Rattus norvegicus	22-33
1684820-6	1991	Administration of the vasopressin receptor antagonist, SK&amp;F 105494, to either dogs or cynomolgus monkeys demonstrated that antagonism of the vasopressin V2 receptor could result in a brisk water diuresis in both species.	Water	193-198	arginine vasopressin	Rattus norvegicus	145-156
1660261-9	1991	Hormone-induced changes of intracellular water space could sufficiently explain accompanying liver mass changes induced by glucagon, cAMP, adenosine or vasopressin, but not those by phenylephrine and extracellular ATP.	Water	41-46	arginine vasopressin	Rattus norvegicus	152-163
1932015-5	1991	The data show that the guanine amino group of the nucleotide interacts differently with both EF-Tu and p21 than it does with water, showing a change in hydrogen-bonding properties upon binding.	Water	125-130	Tu translation elongation factor, mitochondrial	Homo sapiens	93-98
1687373-5	1991	Stimulation of the vasopressin/oxytocin neurosecretory system by water deprivation increased glutamate content in pituicytes and mitochondria within neurosecretory endings but had little influence on microvesicle glutamate content.	Water	65-70	arginine vasopressin	Rattus norvegicus	19-30
1659234-3	1991	Vasopressin infusion (0.01 ng.kg-1.min-1) in five dogs resulted in a decrease in free water clearance from 2.90 +/- 0.42 to -0.34 +/- 0.08 ml/min.	Water	86-91	arginine vasopressin	Rattus norvegicus	0-11
1951766-2	1991	Angiotensin II has been shown to have a role in water deprivation-induced thirst.	Water	48-53	angiotensinogen	Rattus norvegicus	0-14
1658188-3	1991	To this, membrane lipids of the human histiocytic cell line U937 were labeled by incubation with various radioactive precursors, and TNF-induced changes in phospholipid, neutral lipid, and water-soluble metabolites were analyzed by thin layer chromatography.	Water	189-194	tumor necrosis factor	Homo sapiens	133-136
1782804-5	1991	The results suggest that TGF-beta synthesized by the endothelial cells and pericytes may regulate the synthesis and composition of extracellular matrix components in the vascular basal lamina during the course of EAU development.	Water	213-216	transforming growth factor, beta 1	Rattus norvegicus	25-33
1784343-6	1991	A transient increase of water intake was detected on the day of VP-Ab treatment only, which provides direct evidence for at least partial neutralization of vasopressin in the circulation.	Water	24-29	arginine vasopressin	Rattus norvegicus	156-167
1784343-8	1991	Furthermore, these results support the assumption that disturbance in the regulation of water and electrolyte balance at the level of the neuro-intermediate lobe of the pituitary gland may alter PRL secretion during lactation.	Water	88-93	prolactin	Rattus norvegicus	195-198
1937681-2	1991	Nonosmotic vasopressin release has been implicated in the water retention of these edematous disorders.	Water	58-63	arginine vasopressin	Homo sapiens	11-22
1937681-9	1991	The slower response to restoring EABV involves vasopressin-mediated water retention and aldosterone-mediated sodium retention.	Water	68-73	arginine vasopressin	Homo sapiens	47-58
1937681-10	1991	The resultant renal vasoconstriction limits the distal tubular delivery of sodium and water, thus maximizing the water-retaining effect of vasopressin and impairing the normal escape from the sodium-retaining effects of aldosterone.	Water	86-91	arginine vasopressin	Homo sapiens	139-150
1937681-10	1991	The resultant renal vasoconstriction limits the distal tubular delivery of sodium and water, thus maximizing the water-retaining effect of vasopressin and impairing the normal escape from the sodium-retaining effects of aldosterone.	Water	113-118	arginine vasopressin	Homo sapiens	139-150
1961202-1	1991	Murine T cells synthesize and express a cell-surface glycophospholipid anchored 40 kDa and a secreted water-soluble 39 kDa Qa-2 polypeptide.	Water	102-107	Qa lymphocyte antigen 2 region	Mus musculus	123-127
1961202-2	1991	We have examined the biosynthetic pathways which lead to the production of the membrane-bound and water-soluble isoforms of the Qa-2 molecule.	Water	98-103	Qa lymphocyte antigen 2 region	Mus musculus	128-132
1961202-6	1991	Pulse chase experiments and molecular weights of the deglycosylated core polypeptides suggest a precursor to product relationship between the intracellular water-soluble species and the mature 39-kDa secreted Qa-2 molecule.	Water	156-161	Qa lymphocyte antigen 2 region	Mus musculus	209-213
1961202-7	1991	This relationship is supported by the observation that murine L cells transfected with the Qa-2 encoding class I gene Q7 fail to express membrane-bound Qa-2 molecules yet synthesize both intracellular water-soluble and secreted Qa-2 molecules.	Water	201-206	Qa lymphocyte antigen 2 region	Mus musculus	91-95
1931971-9	1991	These results can be seen to be consistent with UVCD and resolution-enhanced FTIR spectra of alpha-lactalbumin and lysozyme in both D2O and H2O environments.	Water	140-143	lactalbumin alpha	Homo sapiens	93-110
1931971-9	1991	These results can be seen to be consistent with UVCD and resolution-enhanced FTIR spectra of alpha-lactalbumin and lysozyme in both D2O and H2O environments.	Water	140-143	lysozyme	Homo sapiens	115-123
1833052-1	1991	A recombinant human alpha-interferon A/D (IFN), also known to be effective in mice, was conjugated to gelatin with a water-soluble carbodiimide.	Water	117-122	interferon alpha 1	Homo sapiens	20-46
1797318-9	1991	Chlorpropamide potentiated ADH-induced water flow, in keeping with the hypothesis that chlorpropamide sensitizes the renal tubules to ADH-induced water flow.	Water	146-151	arginine vasopressin	Homo sapiens	27-30
1911779-12	1991	We also discuss the effect of proline mutations on the energetics of the folding pathway of the h-lysozyme in water.	Water	110-115	lysozyme	Homo sapiens	98-106
1911755-9	1991	Quantitative analysis of the FT-IR spectra of calmodulin (67% alpha-helix) and parvalbumin (68% alpha-helix) in H2O in the presence of Ca2+ gives helical contents similar to those reported by X-ray studies.	Water	112-115	calmodulin 1	Homo sapiens	46-56
1896087-2	1991	The translocation of apo B100 into the endoplasmic reticulum (ER) and its subsequent assembly into lipoprotein particles is of particular interest as the protein is both very large (relative molecular mass 512,000) and insoluble in water.	Water	232-237	apolipoprotein B	Homo sapiens	21-29
1797318-4	1991	The influence of carbamazepine, chlorpropamide and demeclocycline on the antidiuretic hormone (ADH)-induced water flow rate was examined.	Water	108-113	arginine vasopressin	Homo sapiens	95-98
1928422-5	1991	After recovery from surgery, water consumption by lesioned rats was significantly greater than consumption by vehicle or uninjected control rats when challenged with subcutaneous angiotensin II or isoproterenol to stimulate drinking.	Water	29-34	angiotensinogen	Rattus norvegicus	179-193
1797318-9	1991	Chlorpropamide potentiated ADH-induced water flow, in keeping with the hypothesis that chlorpropamide sensitizes the renal tubules to ADH-induced water flow.	Water	146-151	arginine vasopressin	Homo sapiens	134-137
1797318-6	1991	No antidiuretic activity due to carbamazepine alone was observed but a slight inhibition due to ADH-induced water flow was observed in the presence of carbamazepine over a selected dose-range.	Water	108-113	arginine vasopressin	Homo sapiens	96-99
1797318-9	1991	Chlorpropamide potentiated ADH-induced water flow, in keeping with the hypothesis that chlorpropamide sensitizes the renal tubules to ADH-induced water flow.	Water	39-44	arginine vasopressin	Homo sapiens	27-30
1797318-11	1991	Demeclocycline inhibited ADH-induced water flow.	Water	37-42	arginine vasopressin	Homo sapiens	25-28
1764817-0	1991	Vasopressin response to haemorrhage in rats: effect of hypoxia and water restriction.	Water	67-72	arginine vasopressin	Rattus norvegicus	0-11
1657493-4	1991	Urinary excretion of arginine-vasopressin was increased in hyperthyroid and reduced in hypothyroid rats with respect to controls, in response to water deprivation or a hypertonic saline load.	Water	145-150	arginine vasopressin	Rattus norvegicus	30-41
1838023-5	1991	The short-term action of ANF to accelerate salt and water excretion may play a role in the overall response to acute volume overload.	Water	52-57	natriuretic peptide A	Homo sapiens	25-28
1838023-7	1991	In contrast, contributions of ANF to the precise day-to-day regulation of salt and water excretion are likely to be chiefly due to ANF-mediated inhibition of NaCl and water absorption in collecting ducts, but may also involve actions of ANF on the loop of Henle.	Water	83-88	natriuretic peptide A	Homo sapiens	30-33
1838023-7	1991	In contrast, contributions of ANF to the precise day-to-day regulation of salt and water excretion are likely to be chiefly due to ANF-mediated inhibition of NaCl and water absorption in collecting ducts, but may also involve actions of ANF on the loop of Henle.	Water	83-88	natriuretic peptide A	Homo sapiens	131-134
1838023-7	1991	In contrast, contributions of ANF to the precise day-to-day regulation of salt and water excretion are likely to be chiefly due to ANF-mediated inhibition of NaCl and water absorption in collecting ducts, but may also involve actions of ANF on the loop of Henle.	Water	83-88	natriuretic peptide A	Homo sapiens	131-134
1838023-7	1991	In contrast, contributions of ANF to the precise day-to-day regulation of salt and water excretion are likely to be chiefly due to ANF-mediated inhibition of NaCl and water absorption in collecting ducts, but may also involve actions of ANF on the loop of Henle.	Water	167-172	natriuretic peptide A	Homo sapiens	30-33
1838023-7	1991	In contrast, contributions of ANF to the precise day-to-day regulation of salt and water excretion are likely to be chiefly due to ANF-mediated inhibition of NaCl and water absorption in collecting ducts, but may also involve actions of ANF on the loop of Henle.	Water	167-172	natriuretic peptide A	Homo sapiens	131-134
1838023-7	1991	In contrast, contributions of ANF to the precise day-to-day regulation of salt and water excretion are likely to be chiefly due to ANF-mediated inhibition of NaCl and water absorption in collecting ducts, but may also involve actions of ANF on the loop of Henle.	Water	167-172	natriuretic peptide A	Homo sapiens	131-134
1764817-2	1991	The aim of the present study was to determine the effect of water restriction and/or hypoxia on the vasopressin response to haemorrhage in conscious rats.	Water	60-65	arginine vasopressin	Rattus norvegicus	100-111
1764817-7	1991	Water restricted rats had elevated pre-haemorrhage vasopressin levels.	Water	0-5	arginine vasopressin	Rattus norvegicus	51-62
1764817-9	1991	Water restriction (N - W) or hypoxia (H + W) each augmented the vasopressin response to haemorrhage.	Water	0-5	arginine vasopressin	Rattus norvegicus	64-75
1764817-12	1991	Hypoxia or water restriction per se augment the vasopressin response to haemorrhage.	Water	11-16	arginine vasopressin	Rattus norvegicus	48-59
1764817-13	1991	This augmented vasopressin response to haemorrhage is not maintained when hypoxia and water restriction are combined.	Water	86-91	arginine vasopressin	Rattus norvegicus	15-26
1915064-5	1991	Ang II elicited water intake at doses of 50 and 500 ng, but not at the 10- or 1-ng doses.	Water	16-21	angiotensinogen	Rattus norvegicus	0-6
1915064-10	1991	These results demonstrate that, in male rats, the inhibitory effects of icv administration of Ang II on PRL secretion are very sensitive and are observed at doses which do not affect water intake.	Water	183-188	angiotensinogen	Rattus norvegicus	94-100
1795759-3	1991	Immobilization stress for 18 hours (which was accompanied by food and water deprivation) significantly increased MT levels in the frontal cortex, pons plus medulla oblongata and hypothalamus, but not in midbrain and hippocampus.	Water	70-75	metallothionein 1	Rattus norvegicus	113-115
1684731-15	1991	The data suggest that the discharge of central alpha-adrenergic receptors has a dual (inhibitory and excitatory) effect on water intake induced by central AII.	Water	123-128	angiotensinogen	Rattus norvegicus	155-158
33874131-7	1991	Net CO2 uptake integrated over 24 h, which is more pertinent to productivity than are instantaneous CO2 uptake rates, is similar for the three pathways, although the higher water-use efficiency of CAM plants can be an advantage during drought.	Water	173-178	calmodulin 3	Homo sapiens	197-200
33874131-14	1991	Thus, CAM plants are capable of similar high productivities, which can become especially advantageous in regions of substantial water stress.	Water	128-133	calmodulin 3	Homo sapiens	6-9
1653534-1	1991	We have used the isolated perfused tubule technique, measurements of adenosine 3",5"-cyclic monophosphate (cAMP) content in single tubules, and freeze-fracture electron microscopy to study the basis of high vasopressin-independent (basal) osmotic water permeability (Pf) in the terminal inner medullary collecting duct (IMCD) of the rat.	Water	247-252	arginine vasopressin	Rattus norvegicus	207-218
1806308-0	1991	[Effect of water extract of 4 Chinese herbal drugs on the binding of insulin with human erythrocyte insulin receptor].	Water	11-16	insulin	Homo sapiens	69-76
1806308-0	1991	[Effect of water extract of 4 Chinese herbal drugs on the binding of insulin with human erythrocyte insulin receptor].	Water	11-16	insulin	Homo sapiens	100-107
1812278-6	1991	The active principles for the protection of CCl4-induced liver injury were recognized in a fraction (EF 3-3) obtained by using silica gel chromatography (solvent: CHCl3-MeOH-H2O).	Water	174-177	C-C motif chemokine ligand 4	Rattus norvegicus	44-48
1920434-9	1991	An RGD sequence, which is generally known to be involved in cell surface receptor interactions, occurs in thrombin and is associated with a long solvent channel filled with water molecules leading to the surface from the end of the S1 site.	Water	173-178	coagulation factor II, thrombin	Homo sapiens	106-114
1920440-6	1991	Water molecules interacting with alpha-helices occur mainly at the amino and carbonyl termini of the helices, in which case the solvent sites maintain the hydrogen bonding by bridging between residues i and i-3 or i-4 at the amino terminus and between i and i+3 or i+4 at the carbonyl terminus.	Water	0-5	PPP1R2C family member C	Homo sapiens	214-217
1654278-1	1991	The interaction of Zn2+ with angiotensin I, a decapeptide containing two histidyl residues, has been studied by 1H-NMR spectroscopy in both water and dimethylsulfoxide.	Water	140-145	angiotensinogen	Homo sapiens	29-42
1653534-3	1991	They also showed that the basal Pf of the terminal IMCD is regulated by in vivo factors related to water intake, such that a very high vasopressin-independent Pf can be induced in isolated tubules by prior in vivo thirsting.	Water	99-104	arginine vasopressin	Rattus norvegicus	135-146
1653534-6	1991	Water loading of the rats suppressed the incidence of clusters almost entirely but did not fully suppress the basal Pf in the terminal IMCD, raising the possibility that a component of transepithelial water transport may occur independently of the vasopressin-regulated IMP clusters.	Water	0-5	arginine vasopressin	Rattus norvegicus	248-259
1837330-4	1991	We hypothesise that ANP may also play a role in the pathogenesis of asthma through changes in the transport of water and ions across the airway epithelium.	Water	111-116	natriuretic peptide A	Homo sapiens	20-23
1887951-1	1991	Water and 3% NaCl intake were increased by the injection of 4 ng angiotensin II (ANG II) into the anteroventral third ventricle (AV3V) region of rats.	Water	0-5	angiotensinogen	Rattus norvegicus	65-79
1887951-1	1991	Water and 3% NaCl intake were increased by the injection of 4 ng angiotensin II (ANG II) into the anteroventral third ventricle (AV3V) region of rats.	Water	0-5	angiotensinogen	Rattus norvegicus	81-87
8577140-3	1991	Vitamin B1 deficiency (hydroxy thiamine in drinking water at a dose of 2 mg/kg body weight for 15 days) led to a substantial decrease of TK in blood, AlAT and AsAT in the spleen; it diminished AsAT and increased AlAT in the thymus.	Water	52-57	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	159-163
8577140-3	1991	Vitamin B1 deficiency (hydroxy thiamine in drinking water at a dose of 2 mg/kg body weight for 15 days) led to a substantial decrease of TK in blood, AlAT and AsAT in the spleen; it diminished AsAT and increased AlAT in the thymus.	Water	52-57	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	193-197
1887951-2	1991	Pretreatment with two specific ANG II receptor antagonists, [octanoyl-Leu8]ANG II and [Leu8]ANG II, significantly reduced ANG II-induced water and saline intake.	Water	137-142	angiotensinogen	Rattus norvegicus	31-37
1887951-2	1991	Pretreatment with two specific ANG II receptor antagonists, [octanoyl-Leu8]ANG II and [Leu8]ANG II, significantly reduced ANG II-induced water and saline intake.	Water	137-142	angiotensinogen	Rattus norvegicus	70-81
1887951-2	1991	Pretreatment with two specific ANG II receptor antagonists, [octanoyl-Leu8]ANG II and [Leu8]ANG II, significantly reduced ANG II-induced water and saline intake.	Water	137-142	angiotensinogen	Rattus norvegicus	87-98
1887951-2	1991	Pretreatment with two specific ANG II receptor antagonists, [octanoyl-Leu8]ANG II and [Leu8]ANG II, significantly reduced ANG II-induced water and saline intake.	Water	137-142	angiotensinogen	Rattus norvegicus	75-81
1887951-4	1991	In rats with electrolytic lesion of the bilateral ventromedial nucleus of hypothalamus (VMH), the effect of ANG II on water intake was not different from that observed in sham rats, but saline ingestion increased.	Water	118-123	angiotensinogen	Rattus norvegicus	108-114
1874176-1	1991	A water-soluble quinone, coenzyme Q0 (CoQ0), was shown to stimulate insulin release, and dicumarol, an inhibitor of quinone reductase, inhibited glucose-induced insulin release in pancreatic islets.	Water	2-7	insulin	Homo sapiens	68-75
1758237-3	1991	It was demonstrated in 12 patients in a controlled study that besides other known secretions of gastrointestinal hormones, there is also a significant rise of the plasma level of neurotensin when Bad Mergentheimer Karlsquelle mineral water containing sulfate (3.7 g SO4/l) is drunk on an empty stomach (300 ml, 26 degrees C).	Water	234-239	neurotensin	Homo sapiens	179-190
1909176-8	1991	Phe-198 is thus a major contributor to the low CO2 hydration activity, the weak binding of acetazolamide, and the low pKa of the zinc-bound water in carbonic anhydrase III.	Water	140-145	carbonic anhydrase 3	Homo sapiens	149-171
1944811-0	1991	Vasopressin mRNA expression in individual magnocellular neuroendocrine cells of the supraoptic and paraventricular nucleus in response to water deprivation.	Water	138-143	arginine vasopressin	Homo sapiens	0-11
1944811-3	1991	Analysis of autoradiographic silver grain densities from in situ hybridization of an [125I]dCTP-labeled oligonucleotide specific for vasopressin mRNA revealed a wide variety of resting vasopressin mRNA levels and differential responses to water deprivation in the magnocellular neuroendocrine cells.	Water	239-244	arginine vasopressin	Homo sapiens	133-144
1944811-4	1991	During water deprivation, the vasopressin mRNA content of the paraventricular nucleus increases rapidly and with shorter latency and greater incremental response than the supraoptic nucleus.	Water	7-12	arginine vasopressin	Homo sapiens	30-41
1783623-1	1991	Octadecyl (C18)-bonded porous silica was evaluated for the extraction of triazine and organophosphorus pesticides from natural water.	Water	127-132	Bardet-Biedl syndrome 9	Homo sapiens	11-14
1783623-2	1991	The extraction results showed an effective performance when 11 of water was passed through small glass columns containing 500 mg of 50-100-microns C18 bonded porous silica.	Water	66-71	Bardet-Biedl syndrome 9	Homo sapiens	147-150
1962535-4	1991	Water deprivation increased AVP mRNA in both nuclei as previously reported.	Water	0-5	arginine vasopressin	Rattus norvegicus	28-31
1831329-8	1991	High circulating ANP levels may be responsible in part for the suppression of vasopressin levels and water diuresis seen during states of volume expansion.	Water	101-106	natriuretic peptide A	Homo sapiens	17-20
1678278-0	1991	Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy.	Water	76-81	prion protein	Homo sapiens	63-72
1867185-6	1991	These studies show that marked impairment of renal water excretion coupled with unrestricted water intake can result in altered osmoregulation of vasopressin release in association with persistent plasma hypo-osmolality, which can be corrected by fluid restriction.	Water	51-56	arginine vasopressin	Homo sapiens	146-157
1962535-8	1991	Plasma AVP and osmolality levels were significantly elevated in water-deprived rats but not in food-deprived rats.	Water	64-69	arginine vasopressin	Rattus norvegicus	7-10
1868846-1	1991	One- and two-dimensional NMR studies were performed on the complexes of porcine pancreatic phospholipase A2 with substrate analogs bound to a micellar lipid-water interface of fully deuterated dodecylphosphocholine.	Water	157-162	phospholipase A2 group IB	Homo sapiens	91-107
1930852-4	1991	Otherwise, plasma renin activity and plasma aldosterone were significantly reduced (P less than .05 and P less than .01 respectively) by water immersion and plasma aldosterone invariably fell below 10 ng/dL in patients with idiopathic aldosteronism.	Water	137-142	renin	Homo sapiens	18-23
1833019-0	1991	The interaction between atrial natriuretic peptides and angiotensin II in controlling sodium and water excretion in the rat.	Water	97-102	angiotensinogen	Rattus norvegicus	56-70
1833019-9	1991	In another group of rats given captopril, angiotensin II at ongkg-1 min1 was also infused; this had no effect on blood pressure or renal haemodynamics, but partially restored basal levels of sodium and water excretion to those obtained before captopril.	Water	202-207	angiotensinogen	Rattus norvegicus	42-56
1830455-0	1991	Quantitation and topography of membrane proteins in highly water-permeable vesicles from ADH-stimulated toad bladder.	Water	59-64	arginine vasopressin	Homo sapiens	89-92
1653713-14	1991	Moreover, it is considered that ANP increases sodium and water excretion through its effect on both renal glomeruli and distal tubules in EH.	Water	57-62	natriuretic peptide A	Homo sapiens	32-35
1650249-1	1991	Protonic conduction studies are reported for lysozyme as a function of the number of bound water molecules.	Water	91-96	lysozyme	Homo sapiens	45-53
1951063-3	1991	Under similar conditions, however, the rate of hydrolysis for tetramethoxysilane in deionized water was measured to be considerably slower (k = 0.022 min-1; t 1/2 = 32 min) than that of trimethoxysilane (k greater than 8.1 min-1, t 1/2 less than 0.09 min).	Water	94-99	CD59 molecule (CD59 blood group)	Homo sapiens	150-155
1951063-3	1991	Under similar conditions, however, the rate of hydrolysis for tetramethoxysilane in deionized water was measured to be considerably slower (k = 0.022 min-1; t 1/2 = 32 min) than that of trimethoxysilane (k greater than 8.1 min-1, t 1/2 less than 0.09 min).	Water	94-99	CD59 molecule (CD59 blood group)	Homo sapiens	223-228
1951063-4	1991	However, the rates of hydrolysis for methyltrimethoxysilane in water, sodium phosphate buffer at pH 7.4, and 10% rat serum were measured to be 0.03 min-1 (t 1/2 = 24 min), 0.10 min-1 (t 1/2 = 6.7 min), and 0.08 min-1 (t 1/2 = 8.6 min), respectively.	Water	63-68	CD59 molecule (CD59 blood group)	Homo sapiens	148-153
2069952-1	1991	The structure of human parathyroid hormone fragment (1-34) in a solvent mixture of water and trifluoroethanol has been determined by 1H nuclear magnetic resonance spectroscopy and a combination of distance geometry and molecular dynamic simulations.	Water	83-88	parathyroid hormone	Homo sapiens	23-42
1830455-1	1991	Antidiuretic hormone (ADH) stimulation of toad bladder granular cells rapidly increases the osmotic water permeability (Pf) of their apical membranes by insertion of highly selective water channels.	Water	100-105	arginine vasopressin	Homo sapiens	0-20
1830455-1	1991	Antidiuretic hormone (ADH) stimulation of toad bladder granular cells rapidly increases the osmotic water permeability (Pf) of their apical membranes by insertion of highly selective water channels.	Water	100-105	arginine vasopressin	Homo sapiens	22-25
1830455-5	1991	Protein components of the ADH water channel contained within these retrieved vesicles would be expected to be integral membrane protein(s) that span the vesicle"s lipid bilayer to create narrow aqueous channels.	Water	30-35	arginine vasopressin	Homo sapiens	26-29
1858896-0	1991	ADH-induced water permeability and particle aggregates: alteration by a synthetic estrogen.	Water	12-17	arginine vasopressin	Homo sapiens	0-3
1858896-1	1991	In the amphibian urinary bladder, the increase in water permeability induced by antidiuretic hormone (ADH) is accompanied by the appearance of apical intramembrane particle (IMP) aggregates that are believed to contain specific channels for water.	Water	50-55	arginine vasopressin	Homo sapiens	80-100
1832749-0	1991	Central effects of antiserum against human atrial natriuretic polypeptide on water and electrolyte metabolism and plasma arginine-8-vasopressin level in conscious rats.	Water	77-82	natriuretic peptide A	Homo sapiens	43-73
1858896-1	1991	In the amphibian urinary bladder, the increase in water permeability induced by antidiuretic hormone (ADH) is accompanied by the appearance of apical intramembrane particle (IMP) aggregates that are believed to contain specific channels for water.	Water	50-55	arginine vasopressin	Homo sapiens	102-105
1858896-1	1991	In the amphibian urinary bladder, the increase in water permeability induced by antidiuretic hormone (ADH) is accompanied by the appearance of apical intramembrane particle (IMP) aggregates that are believed to contain specific channels for water.	Water	241-246	arginine vasopressin	Homo sapiens	80-100
1858896-1	1991	In the amphibian urinary bladder, the increase in water permeability induced by antidiuretic hormone (ADH) is accompanied by the appearance of apical intramembrane particle (IMP) aggregates that are believed to contain specific channels for water.	Water	241-246	arginine vasopressin	Homo sapiens	102-105
1858896-4	1991	The results point to a selective inhibition of the ADH-induced net water flow, probably due to an interference with one of the last steps of the response to the hormone.	Water	67-72	arginine vasopressin	Homo sapiens	51-54
1858896-8	1991	These results suggest that 1) apical DADES treatment stimulates the insertion of IMP aggregates in the apical membrane of the urinary bladder and 2) DADES inhibits the ADH-induced water flow by interfering with the aggregates and thus probably by blocking the specific water channels.	Water	180-185	arginine vasopressin	Homo sapiens	168-171
1858896-8	1991	These results suggest that 1) apical DADES treatment stimulates the insertion of IMP aggregates in the apical membrane of the urinary bladder and 2) DADES inhibits the ADH-induced water flow by interfering with the aggregates and thus probably by blocking the specific water channels.	Water	269-274	arginine vasopressin	Homo sapiens	168-171
1905326-5	1991	In the presence of 10(-8) M arginine vasopressin, urea permeability increased when NaCl was added to raise osmolality from 290 to 490 mOsm/kg H2O but there was no further increase at 690 mOsm/kg H2O.	Water	142-145	arginine vasopressin	Rattus norvegicus	37-48
1905326-5	1991	In the presence of 10(-8) M arginine vasopressin, urea permeability increased when NaCl was added to raise osmolality from 290 to 490 mOsm/kg H2O but there was no further increase at 690 mOsm/kg H2O.	Water	195-198	arginine vasopressin	Rattus norvegicus	37-48
1930800-3	1991	Oversecretion or undersecretion of vasopressin, eg, diabetes insipidus (DI) or syndrome of inappropriate secretion of antidiuretic hormone (SIADH) results in an imbalance of the salt-to-water ratio.	Water	186-191	arginine vasopressin	Homo sapiens	35-46
2058742-0	1991	Involvement of angiotensin II in water intake of genetically polydipsic mice.	Water	33-38	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	15-29
1682981-0	1991	Structural-functional features of antidiuretic hormone-induced water transport in the collecting duct.	Water	63-68	arginine vasopressin	Homo sapiens	34-54
1819046-0	1991	Glycation of lysozyme in a restricted water environment.	Water	38-43	lysozyme	Homo sapiens	13-21
1819046-1	1991	Fast atom bombardment mass spectrometry (FAB) was used to determine the glycation sites of lysozyme in a restricted water environment.	Water	116-121	lysozyme	Homo sapiens	91-99
2058742-8	1991	Similarly the ANG II antagonist saralasin, [Sar1,-Ile8]ANG II, injected into the lateral cerebroventricle just before the dark period, significantly reduced water intake for 6 h after injection in the polydipsic mice only.	Water	157-162	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	14-20
2048762-9	1991	In humans, exposure to the acetylcholinesterase inhibitor, Aldicarb, was received through contaminated well water.	Water	108-113	acetylcholinesterase (Cartwright blood group)	Homo sapiens	27-47
2058742-8	1991	Similarly the ANG II antagonist saralasin, [Sar1,-Ile8]ANG II, injected into the lateral cerebroventricle just before the dark period, significantly reduced water intake for 6 h after injection in the polydipsic mice only.	Water	157-162	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	55-61
1804235-1	1991	Antidiuretic hormone increases the water permeability of its target epithelial tissues by triggering the insertion into the apical cell membrane of aggregated intramembrane particles that contain channels specific for water.	Water	35-40	arginine vasopressin	Homo sapiens	0-20
1657215-4	1991	The results obtained are suggestive of the direct involvement of vasopressin in the regulation of membrane protein phosphorylation by cAMP-dependent protein kinase which may increase the permeability of cells for H2O.	Water	213-216	arginine vasopressin	Homo sapiens	65-76
1804235-1	1991	Antidiuretic hormone increases the water permeability of its target epithelial tissues by triggering the insertion into the apical cell membrane of aggregated intramembrane particles that contain channels specific for water.	Water	218-223	arginine vasopressin	Homo sapiens	0-20
1958826-2	1991	The water soluble fraction (infranatant) of pooled milk samples obtained on days 2, 12 or 22 postpartum stimulated Nb2 cell growth in the range of 0.08-2.5 microliters/well.	Water	4-9	contactin 5	Rattus norvegicus	115-118
1958826-11	1991	These initial results indicate the presence of a water-soluble antimitogenic factor in rat milk (rMAF) which inhibits the Nb2 lymphoma cell response to prolactin in a non-competitive manner.	Water	49-54	contactin 5	Rattus norvegicus	122-125
1958841-2	1991	The PRL-like bioactivity in the water-soluble fraction of rat milk (infranatant prepared by ultracentrifugation) exceeded its immunoreactivity 3-7-fold.	Water	32-37	prolactin	Rattus norvegicus	4-7
1919616-0	1991	Molecular dynamics simulation of the renin inhibitor H142 in water.	Water	61-66	renin	Homo sapiens	37-42
1885995-1	1991	We describe a method for plan-view transmission electron microscopy (TEM) sample preparation that takes advantage of extreme etch-rate selectivity in GaAs and AlAs in HF/H2O solutions.	Water	170-173	5'-aminolevulinate synthase 1	Homo sapiens	159-163
1821983-2	1991	Recent studies suggest that low prolactin secretion may be a trait characteristic in SAD and this hormone is known to influence on transport mechanism of water and electrolytes from blood to aqueous humor.	Water	154-159	prolactin	Homo sapiens	32-41
2043649-3	1991	Long-lifetime tyrosinate fluorescence (LTF) of angiotensin II (ANG II) was observed in propylene glycol, trifluoroethanol and isopropanol but not in DMSO or water.	Water	157-162	angiotensinogen	Rattus norvegicus	63-69
2043649-4	1991	The addition of SDS at a concentration sufficient to induce micelle formation in water resulted in LTF for ANG II.	Water	81-86	angiotensinogen	Rattus norvegicus	107-113
2026592-7	1991	A solvent deuterium isotope effect of 1.39 +/- 0.02 was noted for inactivation by 2 and one of 1.31 +/- 0.01 for its hydrolysis, in keeping with a proposed promoted water hydrolytic pathway for peptide hydrolysis by CPA (Christanson, D. W., and Lipscomb, W. N. (1989) Acc.	Water	165-170	carboxypeptidase A1	Homo sapiens	216-219
1908454-7	1991	For limited sample volumes, the eluate from the C18 column is mixed with water, added to an immunosorbent affinity column, and washed with water to remove excess sample matrix and impurities.	Water	139-144	Bardet-Biedl syndrome 9	Homo sapiens	48-51
1866378-2	1991	The use of a 30/70 mixture of trichlorofluoromethane (P11) and dichlorodifluoromethane (P12) resulted in the formation of stable, isotropic systems containing 0.5-2.0% (w/v) SPC and solubilized water; R (moles water/moles SPC), 0.9 to 4.28.	Water	194-199	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	88-91
1665414-6	1991	Water loading test revealed impaired water excretion and poor suppression of plasma ADH.	Water	0-5	arginine vasopressin	Homo sapiens	84-87
1750738-4	1991	The mean tear lysozyme levels of rigid (1.12 +/- 0.54 g/L, P less than .05) and high water-content (1.20 +/- 0.43 g/L, P less than .03) contact lens wearers were increased in comparison with the control group.	Water	85-90	lysozyme	Homo sapiens	14-22
1750738-5	1991	The tear lysozyme difference was significant (P less than .03) between high and low water-content (0.82 +/- 0.20 g/L) contact lens users.	Water	84-89	lysozyme	Homo sapiens	9-17
1750738-7	1991	Contact lens wear is irritating to the cornea and conjunctiva, and tear lysozyme physiology is disturbed most by high water-content contact lenses.	Water	118-123	lysozyme	Homo sapiens	72-80
2067204-3	1991	Previous studies in lupus-prone MRL-lpr/lpr mice treated with 1% DFMO in drinking water have been associated with improved lifespan, and reduced anti-DNA antibody production, lymphadenopathy, and splenic polyamine levels.	Water	82-87	Fas (TNF receptor superfamily member 6)	Mus musculus	40-43
1902909-1	1991	The potent bacterial mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]- furanone) (MX), which is formed during chlorination of drinking water and accounts for about one third of the Ames mutagenicity of tap water, has been studied with respect to its genotoxicity in vitro and in vivo.	Water	138-143	nuclear RNA export factor 1	Rattus norvegicus	205-208
1866378-2	1991	The use of a 30/70 mixture of trichlorofluoromethane (P11) and dichlorodifluoromethane (P12) resulted in the formation of stable, isotropic systems containing 0.5-2.0% (w/v) SPC and solubilized water; R (moles water/moles SPC), 0.9 to 4.28.	Water	210-215	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	88-91
1866378-5	1991	Dynamic fractionation of the output from pressurized aerosols using a four-stage liquid impinger showed that the respirable fraction (as measured by the percentage of emitted droplets with aerodynamic diameters less than 5.5 microns) was highly dependent on SPC concentration and R. A significant correlation between RF and actuator score, based on orifice diameter and length, was also found and confirmed that the highest RF values were achieved with the systems of lowest SPC and water concentrations sprayed through an actuator with the smallest and shortest orifice dimensions.	Water	483-488	proline rich protein gene cluster	Homo sapiens	258-261
2015897-1	1991	The solution conformation of a 21-residue vasoconstrictor peptide endothelin-1 (ET-1) in water-ethylene glycol has been determined by two-dimensional 1H-NMR spectroscopy and constrained molecular dynamics simulations.	Water	89-94	endothelin 1	Homo sapiens	66-78
2021606-1	1991	Protein engineering techniques were used to construct a derivative of the serine protease subtilisin that ligates peptides efficiently in water.	Water	138-143	coagulation factor II, thrombin	Homo sapiens	74-89
2021617-2	1991	On the basis of a limited set of published surface areas, we previously proposed that heat capacity changes (delta C degrees p) for the transfer of hydrocarbons from water to the pure liquid phase and for the folding of globular proteins exhibit the same proportionality to the reduction in water-accessible nonpolar surface area (delta Anp) [Spolar, R.S., Ha, J.H., &amp; Record, M.T., Jr. (1989) Proc.	Water	166-171	natriuretic peptide A	Homo sapiens	337-340
2021617-2	1991	On the basis of a limited set of published surface areas, we previously proposed that heat capacity changes (delta C degrees p) for the transfer of hydrocarbons from water to the pure liquid phase and for the folding of globular proteins exhibit the same proportionality to the reduction in water-accessible nonpolar surface area (delta Anp) [Spolar, R.S., Ha, J.H., &amp; Record, M.T., Jr. (1989) Proc.	Water	291-296	natriuretic peptide A	Homo sapiens	337-340
2021617-7	1991	The consequence of this proposal is that the experimental delta C degrees p for protein folding can be used to obtain estimates of delta Anp and of the contribution to the stability of the folded state from removal of a nonpolar surface from water.	Water	242-247	natriuretic peptide A	Homo sapiens	137-140
1851091-0	1991	Complex formation between chlorophyll a and cytochrome c: surface properties at the air-water interface.	Water	88-93	cytochrome c, somatic	Homo sapiens	44-56
1850253-0	1991	The polyphasic reduction of oxygen to water by purified cytochrome c oxidase.	Water	38-43	cytochrome c, somatic	Homo sapiens	56-68
2051802-4	1991	Antidiuretic hormone (ADH) was measured by plasma/urine osmolality after water deprivation and, in some cases, by administration of hypertonic saline.	Water	73-78	arginine vasopressin	Homo sapiens	0-20
2051802-4	1991	Antidiuretic hormone (ADH) was measured by plasma/urine osmolality after water deprivation and, in some cases, by administration of hypertonic saline.	Water	73-78	arginine vasopressin	Homo sapiens	22-25
2015897-1	1991	The solution conformation of a 21-residue vasoconstrictor peptide endothelin-1 (ET-1) in water-ethylene glycol has been determined by two-dimensional 1H-NMR spectroscopy and constrained molecular dynamics simulations.	Water	89-94	endothelin 1	Homo sapiens	80-84
2049253-10	1991	Whatever the dose, PGE1 induced secretion of water, Na+, K+ and Cl- which was dose-dependent and saturable, with a mean Km of congruent to 6-8 pmol kg-1 min-1, suggesting that at the pharmacological doses used, enterocytes have a saturable membrane site similar to a single class of receptor for PGE1.	Water	45-50	CD59 molecule (CD59 blood group)	Homo sapiens	153-158
1829383-1	1991	The activities of PLD and PLC were examined in purified mast cells by quantitating the mass of the water-soluble hydrolysis products choline and phosphorylcholine, respectively.	Water	99-104	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	18-21
1882708-3	1991	The Stern-Volmer plots yielded the second-order rate constants of 2.94 x 10(9) M-1 S-1 and 3.83 x 10(8) M-1 S-1 for quenching 1O2 with MCLA and NaN3 in water at pH 5.4, respectively.	Water	152-157	tumor associated calcium signal transducer 2	Homo sapiens	79-92
1649430-7	1991	The combined C-ANF/ANF infusion further increased plasma ANF concentration to 2394 +/- 532 pg/mL and resulted in significant increases in urinary flow rate, sodium excretion, osmolar clearance, GFR, and free water clearance compared with C-ANF infusion alone (p less than 0.05).	Water	208-213	natriuretic peptide A	Homo sapiens	13-18
1649430-7	1991	The combined C-ANF/ANF infusion further increased plasma ANF concentration to 2394 +/- 532 pg/mL and resulted in significant increases in urinary flow rate, sodium excretion, osmolar clearance, GFR, and free water clearance compared with C-ANF infusion alone (p less than 0.05).	Water	208-213	natriuretic peptide A	Homo sapiens	15-18
1649430-7	1991	The combined C-ANF/ANF infusion further increased plasma ANF concentration to 2394 +/- 532 pg/mL and resulted in significant increases in urinary flow rate, sodium excretion, osmolar clearance, GFR, and free water clearance compared with C-ANF infusion alone (p less than 0.05).	Water	208-213	natriuretic peptide A	Homo sapiens	19-22
1713498-3	1991	), a cholecystokinin analog, decreased the intake of ethanol while the consumption of tap water remained unchanged in a choice paradigm.	Water	90-95	nuclear RNA export factor 1	Rattus norvegicus	86-89
2049821-1	1991	We used the heat denaturation of lysozyme to induce the in vitro formation of protein deposits on 60 poly-HEMA contact lenses (38.6% water).	Water	133-138	lysozyme	Homo sapiens	33-41
1646259-1	1991	Insulin resistance associated with a hyperinsulinemic response to oral glucose intake has been found in patients with essential hypertension and is believed to play a role in inducing hypertension by causing renal sodium and water retention.	Water	225-230	insulin	Homo sapiens	0-7
2002992-1	1991	Primary peripheral arterial vasodilation with relative underfilling of the arterial circulation occurs in early pregnancy and leads to several consequences, including decreased systolic and diastolic blood pressures, enhanced cardiac output secondary to afterload reduction, stimulation of the renin-angiotensin-aldosterone axis, nonosmotic stimulation of thirst and vasopressin release, and renal sodium and water retention with expansion of the extracellular fluid and plasma volume compartments.	Water	409-414	renin	Homo sapiens	294-299
1851783-6	1991	Arteries from rats undergoing DOCA-salt treatment for 5-7 days and from DOCA-treated rats drinking tap water for 4-6 weeks were less responsive to TPA than were arteries from the DOCA-salt hypertensive rats after 4-6 weeks of treatment.	Water	103-108	nuclear RNA export factor 1	Rattus norvegicus	99-102
1912409-0	1991	Antidiuretic hormone modulates membrane phosphoproteins in toad urinary bladder and retrieved water channel containing apical membrane vesicles.	Water	94-99	arginine vasopressin	Homo sapiens	0-20
1912409-1	1991	Antidiuretic hormone (ADH) dramatically increases the water permeability of toad urinary bladder by insertion of unique highly selective water channels into the apical membranes of granular cells.	Water	54-59	arginine vasopressin	Homo sapiens	0-20
1912409-1	1991	Antidiuretic hormone (ADH) dramatically increases the water permeability of toad urinary bladder by insertion of unique highly selective water channels into the apical membranes of granular cells.	Water	54-59	arginine vasopressin	Homo sapiens	22-25
1912409-3	1991	ADH stimulation causes aggrephore fusion with the granular cell apical membrane and increases water permeability.	Water	94-99	arginine vasopressin	Homo sapiens	0-3
1912409-4	1991	Transepithelial osmotic water flow causes a rapid attenuation of the ADH-elicited increase in water permeability through a process called flux inhibition.	Water	24-29	arginine vasopressin	Homo sapiens	69-72
1912409-4	1991	Transepithelial osmotic water flow causes a rapid attenuation of the ADH-elicited increase in water permeability through a process called flux inhibition.	Water	94-99	arginine vasopressin	Homo sapiens	69-72
1652748-0	1991	[Levels of ACTH and cortisol in patients with kidney transplantation examined during water immersion].	Water	85-90	proopiomelanocortin	Homo sapiens	11-15
1901021-3	1991	To examine whether endocytic vesicles which contain the vasopressin-sensitive water channel fuse with acidic vesicles for entry into a lysosomal pathway, ATP-dependent acidification and osmotic water permeability were measured in endosomes from control bladders and bladders treated with vasopressin (VP) and/or phorbol myristate acetate (PMA).	Water	78-83	arginine vasopressin	Homo sapiens	56-67
2003483-4	1991	In both patients, the vasopressin secretion did not respond to either osmotic or nonosmotic stimuli or was suppressed by a water load.	Water	123-128	arginine vasopressin	Homo sapiens	22-33
2028917-5	1991	To the author"s knowledge, this paper is the first to quantify and compare a Freon-based system with a circulating ice water system.	Water	119-124	carboxylesterase 2	Homo sapiens	115-118
2037676-5	1991	The SPC water sampler (Millipore Corp., Bedford, Mass.)	Water	8-13	proline rich protein gene cluster	Homo sapiens	4-7
1854946-3	1991	The important role in the mechanism of the decrease in the water reabsorption in SHR plays the decrease in the content of vasopressin in the blood and urea in the kidney interstitium while in NR a more marked inhibition of the water reabsorption is caused by the decrease in the concentration of both urea and sodium in the kidney layers.	Water	59-64	arginine vasopressin	Rattus norvegicus	122-133
1881392-0	1991	[Study of heat denaturation of human serum albumin in water-alcohol and water-salt solutions in the presence of organic ligands].	Water	54-59	albumin	Homo sapiens	43-50
1854946-3	1991	The important role in the mechanism of the decrease in the water reabsorption in SHR plays the decrease in the content of vasopressin in the blood and urea in the kidney interstitium while in NR a more marked inhibition of the water reabsorption is caused by the decrease in the concentration of both urea and sodium in the kidney layers.	Water	227-232	arginine vasopressin	Rattus norvegicus	122-133
2014161-4	1991	In response to the maternal water restriction, significant increases were noted in maternal and fetal plasma osmolalities (306.6 +/- 1.2 to 315.4 +/- 2.4; 300.5 +/- 1.5 to 311.0 +/- 1.6 mosmol/kg, respectively) and arginine vasopressin concentrations (1.9 +/- 0.2 to 22.6 +/- 5.0; 1.5 +/- 0.1 to 8.5 +/- 2.2 pg/mL, respectively).	Water	28-33	arginine vasopressin	Homo sapiens	224-235
2059662-5	1991	The interaction of apo-alpha-lactalbumin with melittin causes some changes in the environment of its aromatic amino acid residues and drastically alters the conformation of melittin, increasing its alpha-helical content but leaving its single tryptophan residue accessible to water.	Water	276-281	lactalbumin alpha	Homo sapiens	23-40
1988713-9	1991	A decrease in plasma renin activity immediately after treatment is explained by the water immersion and the extracellular volume expansion during treatment.	Water	84-89	renin	Homo sapiens	21-26
1709222-7	1991	ANP (0.005 micrograms/kg/min for 3 h) was administered during maximal water diuresis on both sodium intake levels with and without nitrendipine.	Water	70-75	natriuretic peptide A	Homo sapiens	0-3
19215447-4	1991	A high VP output was found to coincide with increased inhibition of OT release: Subcutaneous injection of graded doses of naloxone (30 min prior to decapitation), augmented OT plasma levels significantly more in 24 h water-deprived male rats than in normally hydrated rats.	Water	217-222	arginine vasopressin	Rattus norvegicus	7-9
1824917-7	1991	These results suggest that production and secretion of both BNP and ANP are concomitantly stimulated by a decreased renal ability to eliminate sodium and water, but this secretion is insufficient to induce effective natriuresis in nephrotic rats.	Water	154-159	natriuretic peptide B	Rattus norvegicus	60-63
1988957-0	1991	Water structure in cubic insulin crystals.	Water	0-5	insulin	Homo sapiens	25-32
1988044-1	1991	The structure of human calcitonin gene-related peptide 1 (hCGRP-1) has been determined by 1H NMR in a mixed-solvent system of 50% trifluoroethanol/50% H2O at pH 3.7 and 27 degrees C. Complete resonance assignment was achieved by using two-dimensional methods.	Water	151-154	calcitonin related polypeptide alpha	Homo sapiens	23-56
1988044-1	1991	The structure of human calcitonin gene-related peptide 1 (hCGRP-1) has been determined by 1H NMR in a mixed-solvent system of 50% trifluoroethanol/50% H2O at pH 3.7 and 27 degrees C. Complete resonance assignment was achieved by using two-dimensional methods.	Water	151-154	calcitonin related polypeptide alpha	Homo sapiens	58-65
1999290-8	1991	A method based on acidification of the water-soluble protein fraction to pH 4.0 has been developed that allows for the isolation of 80%-pure re-hIL-1 beta.	Water	39-44	interleukin 1 beta	Homo sapiens	144-154
1672792-2	1991	The sex of the patients, the history of parental consanguinity, and the fact that both parents formed normally concentrated urine suggested that the NDI in the 2 sisters was the result of inheritance of an autosomal recessive mutation affecting renal tubular water reabsorption.	Water	259-264	arginine vasopressin receptor 2	Homo sapiens	149-152
1833942-1	1991	The potent diuretic and natriuretic properties of atrial natriuretic factor (ANF) suggest that atrial hormones may participate to the regulation of salt and water excretion under physiological conditions.	Water	157-162	natriuretic peptide A	Homo sapiens	50-75
1833942-1	1991	The potent diuretic and natriuretic properties of atrial natriuretic factor (ANF) suggest that atrial hormones may participate to the regulation of salt and water excretion under physiological conditions.	Water	157-162	natriuretic peptide A	Homo sapiens	77-80
1833942-4	1991	ANF may also contribute to the excretion of free water by inhibiting both the secretion of vasopressin and its antidiuretic action.	Water	49-54	natriuretic peptide A	Homo sapiens	0-3
1833942-4	1991	ANF may also contribute to the excretion of free water by inhibiting both the secretion of vasopressin and its antidiuretic action.	Water	49-54	arginine vasopressin	Homo sapiens	91-102
1833942-10	1991	In addition to the well-known osmoregulatory pathways of water metabolism, we recently found that ANF could be involved in the volume adjustment to acute water intake in normal man.	Water	57-62	natriuretic peptide A	Homo sapiens	98-101
1833942-10	1991	In addition to the well-known osmoregulatory pathways of water metabolism, we recently found that ANF could be involved in the volume adjustment to acute water intake in normal man.	Water	154-159	natriuretic peptide A	Homo sapiens	98-101
1668636-2	1991	If the experimental rats are changed to tap water after 15 months of the high sodium diet, the results are partially reversed.	Water	44-49	nuclear RNA export factor 1	Rattus norvegicus	40-43
1668636-5	1991	On the other hand, when the rats on the high sodium diet are changed to control conditions (drinking tap water), their Na+ and Cl- contents decrease, approaching control values.	Water	105-110	nuclear RNA export factor 1	Rattus norvegicus	101-104
1825965-5	1991	Preliminary studies using this technique show that basal skin water loss is significantly diminished in patients with established diabetic neuropathy (0.91 +/- 0.18 g (+/- SD) cm-2 h-1) compared with normal subjects (1.21 +/- 0.39 g cm-2 h-1; p = 0.04) and non-neuropathic diabetic subjects (1.32 +/- 0.48 g cm-2 h-1; p = 0.04), and that local sweating induced by iontophoresis of 10 g l-1 acetylcholine is significantly reduced in diabetic subjects up to 5 min of recording (0.95 +/- 0.43 vs 1.26 +/- 0.40 mg; p = 0.02).	Water	62-67	L1 cell adhesion molecule	Homo sapiens	386-389
1842937-3	1991	Expansion of the extracellular volume stimulates secretion of ANF which consequently contributes to renal excretion of sodium and water.	Water	130-135	natriuretic peptide A	Homo sapiens	62-65
1647232-3	1991	Preincubation of bladders in 10(-4) M neomycin led to a 26% increase in vasopressin-stimulated water flow, a block of PIP2 breakdown, and a reduction in PGE synthesis of 62%.	Water	95-100	arginine vasopressin	Homo sapiens	72-83
2070435-6	1991	The reactions responsible for the BH4-antioxidation system may consist of the non-enzymatic and the peroxidase-catalyzed reduction of H2O2 to H2O by BH4 and the regeneration of BH4 by DHPR using NADH as the cofactor.	Water	134-137	quinoid dihydropteridine reductase	Homo sapiens	184-188
1711973-2	1991	This is observed either at relatively high water content at a given cytochrome c concentration or at low content on increasing the cytochrome c concentration.	Water	43-48	cytochrome c, somatic	Homo sapiens	68-80
1761185-5	1991	In the present study we investigated whether central administration of prolactin would increase food intake in satiated pigs trained to make operant responses for food and water.	Water	172-177	prolactin	Sus scrofa	71-80
1761187-8	1991	injected angiotensin II (ANG II)-induced water intake.	Water	41-46	angiotensinogen	Rattus norvegicus	9-23
1761187-8	1991	injected angiotensin II (ANG II)-induced water intake.	Water	41-46	angiotensinogen	Rattus norvegicus	25-31
1846120-7	1991	Restriction of dietary NaCl (0.13% in chow, tap water to drink) completely prevented DOCA-induced hypertension, organ and CCT hypertrophy, and enhancement of vasopressin-stimulated cAMP formation in the CCT.	Water	48-53	nuclear RNA export factor 1	Rattus norvegicus	44-47
2046458-2	1991	The intracerebroventricular (icv) administration of IL-1 beta significantly inhibited the occurrence of water-immersion restraint stress-induced gastric erosion at doses of 200 ng, 500 ng and 1 microgram, whereas the intravenous (iv) administration of IL-1 beta altered the occurrence of gastric erosion only at a dose of 1 microgram.	Water	104-109	interleukin 1 beta	Rattus norvegicus	52-61
26185965-0	1991	Activation to the transition state: reactant and solvent energy flow for a model SN2 reaction in water.	Water	97-102	solute carrier family 38 member 5	Homo sapiens	81-84
1725429-1	1991	We assessed whether there is an interaction between angiotensin II (Ang II) and endothelin-1 (ET-1) in the regulation of blood pressure and sodium and water metabolism in rats.	Water	151-156	endothelin 1	Rattus norvegicus	94-98
2051714-0	1991	[Effect of water immersion on the cortisol, glucose, growth hormone and prolactin levels in patients with transplanted heart].	Water	11-16	growth hormone 1	Homo sapiens	53-67
2051714-0	1991	[Effect of water immersion on the cortisol, glucose, growth hormone and prolactin levels in patients with transplanted heart].	Water	11-16	prolactin	Homo sapiens	72-81
1725405-1	1991	Circular dichroism of endothelin-1 synthesized through a continuous flow process reveals, when dissolved in water, a strong concentration dependence of the spectrum.	Water	108-113	endothelin 1	Homo sapiens	22-34
1705651-1	1991	Haloperidol, administered to mice in their drinking water, produced a 21% increase in striatal D2 dopamine receptor density after seven days of continuous exposure.	Water	52-57	dopamine receptor D2	Mus musculus	95-115
1648652-0	1991	Site-specific water proton relaxation enhancement of iron(III) chelates noncovalently bound to human serum albumin.	Water	14-19	albumin	Homo sapiens	101-114
1648652-3	1991	Interestingly, binding results in a decrease in the diamagnetic component of the water relaxivity due to HSA, while the expected enhancement of the paramagnetic component of water proton relaxation rates occurs due to the increase in the rotational correlation times of the protein-bound agents.	Water	81-86	albumin	Homo sapiens	105-108
1663207-3	1991	Even the small (30.3%) and brief (45 min) reduction in fractional water excretion with the maximal (1 nM/kg/h) hPTH concentration was approximated by PTHrP.	Water	66-71	parathyroid hormone	Homo sapiens	111-115
1663207-4	1991	It is concluded that the structural homology between hPTH and PTHrP allows a similar action on renal electrolyte transport, including the partial agonist effect of higher concentrations of PTH on vasopressin-induced water transport.	Water	216-221	parathyroid hormone	Homo sapiens	53-57
1663207-4	1991	It is concluded that the structural homology between hPTH and PTHrP allows a similar action on renal electrolyte transport, including the partial agonist effect of higher concentrations of PTH on vasopressin-induced water transport.	Water	216-221	arginine vasopressin	Homo sapiens	196-207
1652115-6	1991	In conclusion, reduced water and sodium excretion after frusemide in the nephrotic syndrome is accompanied by a diminished reduction of blood volume, a delayed decrease in atrial natriuretic peptide, and a blunted increase in angiotensin II and aldosterone compared with healthy subjects.	Water	23-28	angiotensinogen	Homo sapiens	226-240
1775251-0	1991	Aluminium content of water for injection used with recombinant human erythropoietin.	Water	21-26	erythropoietin	Homo sapiens	69-83
1803312-3	1991	The untreated control group received tap water.	Water	41-46	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	37-40
1754319-2	1991	Sodium and water retention in patients with the nephrotic syndrome favours an increase of the content of antidiuretic hormone and plasma renin activity.	Water	11-16	renin	Homo sapiens	137-142
2017469-4	1991	Water intake was higher after insulin than saline at 60" and 90".	Water	0-5	insulin	Homo sapiens	30-37
2006398-0	1991	Antidiuretic hormone and renal function after water loading in patients with cirrhosis of the liver.	Water	46-51	arginine vasopressin	Homo sapiens	0-20
2006398-5	1991	In these patients ADH remained abnormally high after water loading.	Water	53-58	arginine vasopressin	Homo sapiens	18-21
1832746-5	1991	(2) In the natriuretic patients, water immersion resulted in a similar magnitude of natriuresis but a higher degree of plasma ANP increment in comparison to the normal controls.	Water	33-38	natriuretic peptide A	Homo sapiens	126-129
1832746-6	1991	(3) Natriuretic and plasma ANP responses to water immersion were not different between the steroid-responsive patients and normal controls.	Water	44-49	natriuretic peptide A	Homo sapiens	27-30
1832746-7	1991	(4) The increase in plasma ANP and the suppression of PRA and PA after 25 g albumin infusion did not result in natriuresis until the further suppression of PRA and PA and the further stimulation of plasma ANP by subsequent water immersion.	Water	223-228	natriuretic peptide A	Homo sapiens	205-208
1832746-8	1991	The above results indicate that the natriuretic and plasma ANP responses to water immersion are related to the basal Na status in nephrotic patients.	Water	76-81	natriuretic peptide A	Homo sapiens	59-62
1906643-3	1991	Verapamil, which inhibits antidiuretic hormone (ADH)-mediated water flow, increased the number, size and distribution of dense calcium-containing secretory granules in bladder epithelial cells.	Water	62-67	arginine vasopressin	Homo sapiens	26-46
1906643-3	1991	Verapamil, which inhibits antidiuretic hormone (ADH)-mediated water flow, increased the number, size and distribution of dense calcium-containing secretory granules in bladder epithelial cells.	Water	62-67	arginine vasopressin	Homo sapiens	48-51
2260984-5	1990	These trifluoromethyl ketones were found to be rapidly reversible, competitive inhibitors of NTE with I50 values 1.3 x 10(-4) M to 4.9 x 10(-8) M. Correlation of I50 values with octanol/water partition coefficients (P), in the range of log P = 1.5 to 5.9. indicated that the optimal lipophilicity for NTE substrates and inhibitors is in the range of log P = 3.0 to 3.4.	Water	186-191	patatin like phospholipase domain containing 6	Gallus gallus	93-96
1796634-6	1991	In more severe heart failure vasoconstrictor, sodium and water-retaining mechanisms like the renin-angiotensin-aldosterone system are activated with the consequence of an increase of systemic vascular resistance, a reduction of renal blood flow, and an increased fluid retention.	Water	57-62	renin	Homo sapiens	93-98
2268666-0	1990	The topography of bovine beta-casein at an oil/water interface as determined from the kinetics of trypsin-catalysed hydrolysis.	Water	47-52	casein beta	Bos taurus	25-36
2268666-1	1990	The topography of bovine beta-casein at a soya oil/water interface was studied by following the kinetics of the trypsin-catalysed hydrolysis.	Water	51-56	casein beta	Bos taurus	25-36
2265703-0	1990	Evidence for aggregation of endothelin 1 in water.	Water	44-49	endothelin 1	Homo sapiens	28-40
2268666-6	1990	This suggests that with the exception of the large hydrophilic moiety in the N-terminal region, most of the beta-casein molecule is inaccessible to the proteinase, and lies fairly flat on the oil/water interface.	Water	196-201	casein beta	Bos taurus	108-119
2265703-1	1990	In this report it is shown by CD spectroscopy that endothelin 1, when dissolved in water, is able to present intermolecular interactions leading to formation of aggregates.	Water	83-88	endothelin 1	Homo sapiens	51-63
1701969-1	1990	Vasopressin action in the renal collecting duct is believed to be mediated by the cycling of water channels in principal and, possibly, intercalated cells.	Water	93-98	arginine vasopressin	Rattus norvegicus	0-11
2280429-5	1990	The experimental animals receiving tap water plus table salt had the highest blood pressure levels, although they consumed the lowest quantity of sodium.	Water	39-44	nuclear RNA export factor 1	Rattus norvegicus	35-38
2174655-4	1990	SRI 63-441 (10 to 20 mg/kg/h) attenuated the endotoxin-induced pulmonary hypertension (peak pulmonary arterial pressure, 53 +/- 12 versus 65 +/- 7 cm H2O; p greater than 0.05) and fall in dynamic compliance of the lungs (to 65.1 +/- 9.8% baseline versus 32.6 +/- 5.1% baseline).	Water	150-153	sorcin	Ovis aries	0-3
2256575-4	1990	These "in vitro" studies have shown an important dose-dependent inhibitory effect of S-H2O on mitogen induced T lymphocyte proliferation and on IL2 production.	Water	87-90	interleukin 2	Homo sapiens	144-147
2207286-1	1990	13C-nmr spectra of lysozyme obtained at 50.3 MHz using both static and magic-angle-spinning-cross-polarization methods are reported at several water contents.	Water	143-148	lysozyme	Homo sapiens	19-27
2280429-6	1990	Analysis of the tap water samples showed "soft water" by analysis of calcium and magnesium concentration.	Water	20-25	nuclear RNA export factor 1	Rattus norvegicus	16-19
2280429-6	1990	Analysis of the tap water samples showed "soft water" by analysis of calcium and magnesium concentration.	Water	47-52	nuclear RNA export factor 1	Rattus norvegicus	16-19
2280429-9	1990	The zinc and copper present in tap water may play an exacerbating role.	Water	35-40	nuclear RNA export factor 1	Rattus norvegicus	31-34
2126286-3	1990	Hot tub water, bath water, chlorinated water, or water from stagnant ponds may pose a risk for either otitis media or otitis externa.	Water	8-13	TUB bipartite transcription factor	Homo sapiens	4-7
2176710-3	1990	In rats drinking 2% NaCl-water for 0,2,4, or 10 days, or for 10 days and then tap water for 14 days, the levels of VP mRNA in the NIL were altered in a fashion that paralleled changes in the hypothalamus.	Water	25-30	arginine vasopressin	Rattus norvegicus	115-117
2247838-3	1990	The purpose of this study was to investigate the role of somatostatin and its analogue octreotide on water and electrolyte transport in the small intestine.	Water	101-106	somatostatin	Oryctolagus cuniculus	57-69
2247838-8	1990	Somatostatin at 10(-5) mol/L yielded a proabsorptive effect on the flux of water and electrolytes.	Water	75-80	somatostatin	Oryctolagus cuniculus	0-12
2240195-1	1990	In human red blood cells, when chloride was replaced isosmotically with a permeant chaotropic anion of the lyotropic series (NO3, I, or SCN), an immediate and significant loss of cell water was observed.	Water	184-189	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
2078164-8	1990	Also, short-term loss of body weight when saline drinking water is replaced with tap water predicts the degree of degeneration of the granule cell layer.	Water	85-90	nuclear RNA export factor 1	Rattus norvegicus	81-84
2078904-6	1990	These results indicate that ILI in the brain may play a role in the secretion of AVP, and that this mechanism could be operated to control a water-sodium balance.	Water	141-146	arginine vasopressin	Rattus norvegicus	81-84
2243344-9	1990	In conscious rats, DuP 753 at 10 mg/kg s.c. but not PD123177 at 100 mg/kg s.c. inhibited the AII-induced water drinking.	Water	105-110	angiotensinogen	Rattus norvegicus	93-96
2226825-0	1990	The actin gelling activity of chicken gizzard alpha-actinin at physiological temperature is triggered by water sequestration.	Water	105-110	actinin, alpha 4	Gallus gallus	46-59
2170353-0	1990	The unstirred water layer as a site of control of apolipoprotein B secretion.	Water	14-19	apolipoprotein B	Homo sapiens	50-66
2170353-4	1990	Polyclonal blocking antibodies to the low density lipoprotein receptor markedly increased apoB output, and varying the width of the unstirred water layer around the cells also changed apoB output, consistent with local reuptake.	Water	142-147	apolipoprotein B	Homo sapiens	184-188
2170353-6	1990	We conclude that a major site of apoB secretory control resides in the unstirred water layer, external to the cell.	Water	81-86	apolipoprotein B	Homo sapiens	33-37
2268141-0	1990	Insulin stimulation of water intake in humans.	Water	23-28	insulin	Homo sapiens	0-7
2268141-2	1990	Water intake was significantly higher after insulin than after saline administration during the 90-min period studied.	Water	0-5	insulin	Homo sapiens	44-51
2268141-3	1990	Plasma glucose decreased significantly in individuals receiving insulin and the time of the maximum decrease (30 min) was concurrent with the beginning of water intake.	Water	155-160	insulin	Homo sapiens	64-71
2128753-10	1990	The results suggest that apolipoproteins may play a role in the regulation of hydrolysis of cholesteryl esters in lipoproteins, that have been transferred to the liver, and that the inhibition of acid CEH activity by apo A-I may be a characteristic of the lipid-binding protein or be due to changes of the lipid/water interface.	Water	312-317	apolipoprotein A1	Homo sapiens	217-224
1965238-4	1990	Aromatase activity was determined by measuring the tritiated water (3H2O) in the medium after incubating stromal cells with [1 beta-3H]androstenedione.	Water	61-66	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
1702320-8	1990	Upon increasing the packing density to concentrations larger than 10(-5) M the surface area was only half as large (148 +/- 5 A2 to 124 +/- 3 A2) suggesting now a relatively extended conformation of the SP molecule with its long molecular axis perpendicular to the air/water interface.	Water	269-274	tachykinin precursor 1	Homo sapiens	203-205
2121338-2	1990	The rate of accumulation of water soluble inositol phosphates in response to several growth factors was much higher in bcl-2 transfected NIH3T3 clones than in untransfected control.	Water	28-33	BCL2 apoptosis regulator	Homo sapiens	119-124
2268737-7	1990	The present investigation thus showed that prolactin, besides stimulating 1,25(OH2)D3 production, may also enhance calcium absorption directly.	Water	79-82	prolactin	Rattus norvegicus	43-52
2176710-3	1990	In rats drinking 2% NaCl-water for 0,2,4, or 10 days, or for 10 days and then tap water for 14 days, the levels of VP mRNA in the NIL were altered in a fashion that paralleled changes in the hypothalamus.	Water	82-87	nuclear RNA export factor 1	Rattus norvegicus	78-81
2176710-3	1990	In rats drinking 2% NaCl-water for 0,2,4, or 10 days, or for 10 days and then tap water for 14 days, the levels of VP mRNA in the NIL were altered in a fashion that paralleled changes in the hypothalamus.	Water	82-87	arginine vasopressin	Rattus norvegicus	115-117
2150808-8	1990	Results also suggest that high circulating ANP might play an important role in sodium and water metabolism and hemodynamic changes in hyperthyroidism.	Water	90-95	natriuretic peptide A	Homo sapiens	43-46
1979609-1	1990	Osmotic water permeability (Pf) in toad bladder is regulated by the vasopressin (VP)-dependent movement of vesicles containing water channels between the cytoplasm and apical membrane of granular cells.	Water	8-13	arginine vasopressin	Homo sapiens	68-79
1979609-1	1990	Osmotic water permeability (Pf) in toad bladder is regulated by the vasopressin (VP)-dependent movement of vesicles containing water channels between the cytoplasm and apical membrane of granular cells.	Water	8-13	arginine vasopressin	Homo sapiens	81-83
1979609-1	1990	Osmotic water permeability (Pf) in toad bladder is regulated by the vasopressin (VP)-dependent movement of vesicles containing water channels between the cytoplasm and apical membrane of granular cells.	Water	127-132	arginine vasopressin	Homo sapiens	68-79
1979609-1	1990	Osmotic water permeability (Pf) in toad bladder is regulated by the vasopressin (VP)-dependent movement of vesicles containing water channels between the cytoplasm and apical membrane of granular cells.	Water	127-132	arginine vasopressin	Homo sapiens	81-83
1979609-11	1990	Pf of endosomes containing the VP-sensitive water channel decreased fourfold by increasing membrane fluidity with hexanol or chloroform (0-75 mM); Pf of phosphatidylcholine liposomes (0.002 cm/s) increased 2.5-fold under the same conditions.	Water	44-49	arginine vasopressin	Homo sapiens	31-33
1979609-13	1990	We conclude that: (a) water channels cycled in endocytic vesicles are functional and not subject to physiological regulation, (b) VP and forskolin do not have cAMP-independent cellular actions, (c) activation of protein kinase C stimulates trafficking of water channels, but does not increase the number of apical membrane water channels induced by maximal VP, and (d) water channel function is sensitive to membrane fluidity.	Water	22-27	arginine vasopressin	Homo sapiens	357-359
1979609-14	1990	By using VP and PMA together, large quantities of endosomes containing the VP-sensitive water channel are labeled with fluid-phase endocytic markers.	Water	88-93	arginine vasopressin	Homo sapiens	9-11
1979609-14	1990	By using VP and PMA together, large quantities of endosomes containing the VP-sensitive water channel are labeled with fluid-phase endocytic markers.	Water	88-93	arginine vasopressin	Homo sapiens	75-77
2151903-0	1990	Water immersion induced alterations of plasma atrial natriuretic peptide (ANP), diuresis and natriuresis in kidney transplant patients.	Water	0-5	natriuretic peptide A	Homo sapiens	46-72
2213199-7	1990	Washing with water through small C18-bonded phase silica cartridges eliminates labeled water and the majority of boron-containing impurities.	Water	13-18	Bardet-Biedl syndrome 9	Homo sapiens	33-36
2213199-7	1990	Washing with water through small C18-bonded phase silica cartridges eliminates labeled water and the majority of boron-containing impurities.	Water	87-92	Bardet-Biedl syndrome 9	Homo sapiens	33-36
2213375-9	1990	This study supports the hypothesis that serum AVP concentrations are elevated in patients with meningitis because of hypovolemia and become normal when sufficient sodium is given to facilitate reabsorption of water by the proximal tubule of the kidney.	Water	209-214	arginine vasopressin	Homo sapiens	46-49
2151903-0	1990	Water immersion induced alterations of plasma atrial natriuretic peptide (ANP), diuresis and natriuresis in kidney transplant patients.	Water	0-5	natriuretic peptide A	Homo sapiens	74-77
2132633-0	1990	Water immersion (WI) induced alterations of plasma vasopressin (AVP) levels in patients with noninflammatory acute renal failure (NARF) and in patients with chronic renal failure (CRF).	Water	0-5	arginine vasopressin	Homo sapiens	51-62
1964888-1	1990	The physiological mechanism regulating secretion of alpha-human atrial natriuretic polypeptide (alpha hANP) was studied by measuring plasma alpha hANP (P alpha hANP) with radioimmunoassay during water immersion (WI).	Water	195-200	natriuretic peptide A	Homo sapiens	102-106
2132633-0	1990	Water immersion (WI) induced alterations of plasma vasopressin (AVP) levels in patients with noninflammatory acute renal failure (NARF) and in patients with chronic renal failure (CRF).	Water	0-5	arginine vasopressin	Homo sapiens	64-67
2132633-1	1990	Water immersion (WI) induced alterations of plasma vasopressin (AVP), plasma osmolality, plasma volume (PV) and plasma sodium and potassium concentration were examined in 12 patients with noninflammatory acute renal failure (NARF) at the anuric/oliguric phase, 20 patients with chronic renal failure (CRF) and 15 healthy persons.	Water	0-5	arginine vasopressin	Homo sapiens	51-62
2132633-1	1990	Water immersion (WI) induced alterations of plasma vasopressin (AVP), plasma osmolality, plasma volume (PV) and plasma sodium and potassium concentration were examined in 12 patients with noninflammatory acute renal failure (NARF) at the anuric/oliguric phase, 20 patients with chronic renal failure (CRF) and 15 healthy persons.	Water	0-5	arginine vasopressin	Homo sapiens	64-67
2280821-0	1990	Rat brain natriuretic peptide (BNP) reduces water intake following dehydration.	Water	44-49	natriuretic peptide B	Rattus norvegicus	4-29
2280821-0	1990	Rat brain natriuretic peptide (BNP) reduces water intake following dehydration.	Water	44-49	natriuretic peptide B	Rattus norvegicus	31-34
2280821-2	1990	Following dehydration for 18h, intracerebroventricular injections of 5 micrograms of rat BNP significantly reduced water consumption 0-2 h after the injections, but not 2-4 h afterwards.	Water	115-120	natriuretic peptide B	Rattus norvegicus	89-92
2280821-6	1990	These findings suggest that BNP may be involved in the central regulation of water consumption.	Water	77-82	natriuretic peptide B	Rattus norvegicus	28-31
1964888-7	1990	These results suggest that alpha hANP is released into the circulation by acute central hypervolemia and plays a physiologically important role in maintaining water and electrolytes homeostasis in normal subjects and that the increased alpha hANP level in nephrotic syndrome makes compensatory regulation in water and electrolytes disorders.	Water	159-164	natriuretic peptide A	Homo sapiens	33-37
2291291-2	1990	Treatment with iontophoresis using tap water resulted in a gradual relief from the pain.	Water	39-44	SEC14 like lipid binding 2	Homo sapiens	35-38
1964888-7	1990	These results suggest that alpha hANP is released into the circulation by acute central hypervolemia and plays a physiologically important role in maintaining water and electrolytes homeostasis in normal subjects and that the increased alpha hANP level in nephrotic syndrome makes compensatory regulation in water and electrolytes disorders.	Water	308-313	natriuretic peptide A	Homo sapiens	33-37
1964888-7	1990	These results suggest that alpha hANP is released into the circulation by acute central hypervolemia and plays a physiologically important role in maintaining water and electrolytes homeostasis in normal subjects and that the increased alpha hANP level in nephrotic syndrome makes compensatory regulation in water and electrolytes disorders.	Water	308-313	natriuretic peptide A	Homo sapiens	242-246
2386243-4	1990	In addition, both peptides increased water intake when food was present but not when food was absent, suggesting that a neural substrate supporting a direct action of NPY and PYY on water intake is not present in the hindbrain.	Water	182-187	neuropeptide Y	Rattus norvegicus	167-170
2394737-1	1990	Evaluation of the double-quantum filter for sodium was performed on several sample series of bovine serum albumin in water.	Water	117-122	albumin	Homo sapiens	100-113
2203255-0	1990	Water volume and consumption time: influence on the glycemic and insulinemic responses in non-insulin-dependent diabetic subjects.	Water	0-5	insulin	Homo sapiens	65-72
2273853-1	1990	The authors discuss the results of application of proteinase preparations immobilized on a water soluble carrier (Immozymase) and a water insoluble carrier (Profezyme) in the management of ++pyo-necrotic processes of various etiology and localization in 1,059 patients.	Water	91-96	endogenous retrovirus group K member 25	Homo sapiens	50-60
2261438-1	1990	The conformation of the polypeptide thymosin beta 4 in solutions of 60% (v/v) trifluoroethanol-d3 and 50% (v/v) hexafluoroisopropyl-d2 alcohol in water is investigated by nuclear magnetic resonance (NMR) spectroscopy.	Water	146-151	thymosin beta 4 X-linked	Homo sapiens	36-51
1696788-1	1990	Antidiuretic hormone (ADH) stimulation of toad urinary bladder granular cells causes simultaneous increases in transepithelial water and H+ permeabilities (PF and PH+, respectively), suggesting that ADH-elicited water channels inserted into granular cell apical membranes might be permeable to both water and H+.	Water	127-132	arginine vasopressin	Homo sapiens	0-20
1696788-1	1990	Antidiuretic hormone (ADH) stimulation of toad urinary bladder granular cells causes simultaneous increases in transepithelial water and H+ permeabilities (PF and PH+, respectively), suggesting that ADH-elicited water channels inserted into granular cell apical membranes might be permeable to both water and H+.	Water	127-132	arginine vasopressin	Homo sapiens	22-25
1696788-1	1990	Antidiuretic hormone (ADH) stimulation of toad urinary bladder granular cells causes simultaneous increases in transepithelial water and H+ permeabilities (PF and PH+, respectively), suggesting that ADH-elicited water channels inserted into granular cell apical membranes might be permeable to both water and H+.	Water	127-132	arginine vasopressin	Homo sapiens	199-202
1696788-1	1990	Antidiuretic hormone (ADH) stimulation of toad urinary bladder granular cells causes simultaneous increases in transepithelial water and H+ permeabilities (PF and PH+, respectively), suggesting that ADH-elicited water channels inserted into granular cell apical membranes might be permeable to both water and H+.	Water	212-217	arginine vasopressin	Homo sapiens	0-20
1696788-1	1990	Antidiuretic hormone (ADH) stimulation of toad urinary bladder granular cells causes simultaneous increases in transepithelial water and H+ permeabilities (PF and PH+, respectively), suggesting that ADH-elicited water channels inserted into granular cell apical membranes might be permeable to both water and H+.	Water	212-217	arginine vasopressin	Homo sapiens	22-25
1696788-1	1990	Antidiuretic hormone (ADH) stimulation of toad urinary bladder granular cells causes simultaneous increases in transepithelial water and H+ permeabilities (PF and PH+, respectively), suggesting that ADH-elicited water channels inserted into granular cell apical membranes might be permeable to both water and H+.	Water	212-217	arginine vasopressin	Homo sapiens	199-202
2396712-1	1990	This study was designed to investigate the effects on water drinking of acute and chronic increases in circulating angiotensin II (ANG II) concentrations in rats.	Water	54-59	angiotensinogen	Rattus norvegicus	115-129
2396712-1	1990	This study was designed to investigate the effects on water drinking of acute and chronic increases in circulating angiotensin II (ANG II) concentrations in rats.	Water	54-59	angiotensinogen	Rattus norvegicus	131-137
2147645-0	1990	Effect of acute water loading on plasma levels of antidiuretic hormone AVP aldosterone, ANP fractional excretion of sodium and plasma and urine osmolalities in myxedema.	Water	16-21	arginine vasopressin	Homo sapiens	50-70
2387259-8	1990	The highest basal release of VP was observed in the explants maintained under isotonic conditions (299 mosm/kg H2O).	Water	111-114	arginine vasopressin	Rattus norvegicus	29-31
2387259-10	1990	Basal VP release was lower in explants maintained in hypertonic medium (greater than 304 mosmol/kg H2O), and these explants did not respond to the acute hypertonic pulse.	Water	99-102	arginine vasopressin	Rattus norvegicus	6-8
2172546-12	1990	Another function of in vivo IMCD cells, vasopressin-dependent formation of endosomes containing water channels, was absent in the cultured cells.	Water	96-101	arginine vasopressin	Rattus norvegicus	40-51
2236903-2	1990	Single organic- and water-soluble metabolites increased with BaP concentration in both types of HSF, but the ratio normal/variant increased with BaP concentration.	Water	20-25	interleukin 6	Homo sapiens	96-99
1696788-1	1990	Antidiuretic hormone (ADH) stimulation of toad urinary bladder granular cells causes simultaneous increases in transepithelial water and H+ permeabilities (PF and PH+, respectively), suggesting that ADH-elicited water channels inserted into granular cell apical membranes might be permeable to both water and H+.	Water	212-217	arginine vasopressin	Homo sapiens	0-20
1696788-1	1990	Antidiuretic hormone (ADH) stimulation of toad urinary bladder granular cells causes simultaneous increases in transepithelial water and H+ permeabilities (PF and PH+, respectively), suggesting that ADH-elicited water channels inserted into granular cell apical membranes might be permeable to both water and H+.	Water	212-217	arginine vasopressin	Homo sapiens	22-25
1696788-1	1990	Antidiuretic hormone (ADH) stimulation of toad urinary bladder granular cells causes simultaneous increases in transepithelial water and H+ permeabilities (PF and PH+, respectively), suggesting that ADH-elicited water channels inserted into granular cell apical membranes might be permeable to both water and H+.	Water	212-217	arginine vasopressin	Homo sapiens	199-202
1696788-10	1990	The apparent high PH+ of the ADH water channel may have important implications for intracellular trafficking of these water channels in ADH-responsive epithelial cells.	Water	33-38	arginine vasopressin	Homo sapiens	29-32
1696788-10	1990	The apparent high PH+ of the ADH water channel may have important implications for intracellular trafficking of these water channels in ADH-responsive epithelial cells.	Water	33-38	arginine vasopressin	Homo sapiens	136-139
2144031-1	1990	The heart atria represent the major site of synthesis of atrial natriuretic peptide (ANP) in mammals including man, and its function as a regulator of water and salt homeostasis has been repeatedly suggested.	Water	151-156	natriuretic peptide A	Homo sapiens	57-83
1974209-3	1990	Using as examples gamma-glutamyltransferase (in AOT reversed micelles in octane) and aminopeptidase (in Brij 96 reversed micelles in cyclohexane), the principal difference in the catalytic activity regulation of water-soluble and membrane forms is demonstrated.	Water	212-217	carboxypeptidase Q	Homo sapiens	85-99
1696262-0	1990	Endocytic vesicles from renal papilla which retrieve the vasopressin-sensitive water channel do not contain a functional H+ ATPase.	Water	79-84	arginine vasopressin	Rattus norvegicus	57-68
1696262-1	1990	The water permeability of the kidney collecting duct epithelium is regulated by vasopressin (VP)-induced recycling of water channels between an intracellular vesicular compartment and the plasma membrane of principal cells.	Water	4-9	arginine vasopressin	Rattus norvegicus	80-91
1696262-1	1990	The water permeability of the kidney collecting duct epithelium is regulated by vasopressin (VP)-induced recycling of water channels between an intracellular vesicular compartment and the plasma membrane of principal cells.	Water	4-9	arginine vasopressin	Rattus norvegicus	93-95
2164058-1	1990	Vasopressin regulates transepithelial osmotic water permeability in the kidney collecting duct and in target cells in other tissues.	Water	46-51	arginine vasopressin	Homo sapiens	0-11
2164058-3	1990	Because cytochalasin B and D greatly reduce the response of these cells to vasopressin, actin filaments are believed to participate in the events leading to an increase in transepithelial water permeability.	Water	188-193	arginine vasopressin	Homo sapiens	75-86
2395065-4	1990	Water transport was also impaired at 144 h PI.	Water	0-5	histocompatibility 52	Mus musculus	41-45
2125706-6	1990	Serum vasopressin concentration was increased following water deprivation, and the increase was comparable in all age groups.	Water	56-61	arginine vasopressin	Rattus norvegicus	6-17
2145657-7	1990	ANP plasma levels tend to be increased in diseases with salt and water retention, such as essential hypertension, congestive heart failure, renal failure or liver cirrhosis.	Water	65-70	natriuretic peptide A	Homo sapiens	0-3
2144031-1	1990	The heart atria represent the major site of synthesis of atrial natriuretic peptide (ANP) in mammals including man, and its function as a regulator of water and salt homeostasis has been repeatedly suggested.	Water	151-156	natriuretic peptide A	Homo sapiens	85-88
2165402-3	1990	Serum albumin was treated with the water-soluble carbodiimide N-ethyl-N"-(3-dimethylaminopropyl) carbodiimide hydrochloride and the resultant positively charged N-acylurea albumin covalently conjugated to insulin by glutaraldehyde cross-linkage.	Water	35-40	albumin	Homo sapiens	0-13
2193561-6	1990	The renal vasoconstriction, which accompanies either decreased cardiac output or peripheral arterial vasodilation, causes a decreased distal tubular delivery of sodium and water, thus maximizing the water-retaining effect of vasopressin and impairing normal escape from the sodium-retaining effect of aldosterone.	Water	172-177	arginine vasopressin	Homo sapiens	225-236
2193561-6	1990	The renal vasoconstriction, which accompanies either decreased cardiac output or peripheral arterial vasodilation, causes a decreased distal tubular delivery of sodium and water, thus maximizing the water-retaining effect of vasopressin and impairing normal escape from the sodium-retaining effect of aldosterone.	Water	199-204	arginine vasopressin	Homo sapiens	225-236
2169869-3	1990	Imidazole enhanced the rate of release of 18O-labeled water from the active site of wild-type carbonic anhydrase III and caused a much greater enhancement, up to 20-fold, for the K64H, R67H, and R67N mutants of this isozyme.	Water	54-59	carbonic anhydrase 3	Homo sapiens	94-116
2169869-2	1990	We report that buffers of small size, especially imidazole, increase the rate of catalysis by human carbonic anhydrase III (HCA III) of (1) 18O exchange between HCO3- and water measured by membrane-inlet mass spectrometry and (2) the dehydration of HCO3- measured by stopped-flow spectrophotometry.	Water	171-176	carbonic anhydrase 3	Homo sapiens	100-122
2146596-5	1990	This effect was accompanied by decreased ANG II-stimulated water intake.	Water	59-64	angiotensinogen	Rattus norvegicus	41-47
2114228-4	1990	The neutrophil-dependent pulmonary edema induced by TNF was associated with a combination of increased capillary permeability (capillary filtration coefficient [Kf,c], 0.170 +/- 0.048 g/min/cm H2O/g at 30 minutes versus 0.118 +/- 0.008 g/min/cm H2O/g at baseline) and increased pulmonary capillary pressure (Ppc, 12.8 +/- 0.8 cm H2O at 60 minutes versus 6.0 +/- 0.3 cm H2O at baseline).	Water	193-196	tumor necrosis factor	Homo sapiens	52-55
2114228-4	1990	The neutrophil-dependent pulmonary edema induced by TNF was associated with a combination of increased capillary permeability (capillary filtration coefficient [Kf,c], 0.170 +/- 0.048 g/min/cm H2O/g at 30 minutes versus 0.118 +/- 0.008 g/min/cm H2O/g at baseline) and increased pulmonary capillary pressure (Ppc, 12.8 +/- 0.8 cm H2O at 60 minutes versus 6.0 +/- 0.3 cm H2O at baseline).	Water	245-248	tumor necrosis factor	Homo sapiens	52-55
2114228-4	1990	The neutrophil-dependent pulmonary edema induced by TNF was associated with a combination of increased capillary permeability (capillary filtration coefficient [Kf,c], 0.170 +/- 0.048 g/min/cm H2O/g at 30 minutes versus 0.118 +/- 0.008 g/min/cm H2O/g at baseline) and increased pulmonary capillary pressure (Ppc, 12.8 +/- 0.8 cm H2O at 60 minutes versus 6.0 +/- 0.3 cm H2O at baseline).	Water	245-248	tumor necrosis factor	Homo sapiens	52-55
2114228-4	1990	The neutrophil-dependent pulmonary edema induced by TNF was associated with a combination of increased capillary permeability (capillary filtration coefficient [Kf,c], 0.170 +/- 0.048 g/min/cm H2O/g at 30 minutes versus 0.118 +/- 0.008 g/min/cm H2O/g at baseline) and increased pulmonary capillary pressure (Ppc, 12.8 +/- 0.8 cm H2O at 60 minutes versus 6.0 +/- 0.3 cm H2O at baseline).	Water	245-248	tumor necrosis factor	Homo sapiens	52-55
2167992-9	1990	The present data suggest that brain ACE is more involved in compound 48/80-induced water intake than peripheral systemic ACE.	Water	83-88	angiotensin I converting enzyme	Rattus norvegicus	36-39
2375429-2	1990	AVP at 1 pg.min-1.kg-1 (approximately 10(-15) mol.min-1.kg-1) decreased urine flow (12.2 +/- 1.7 to 7.4 +/- 1.5 ml/min) and free water clearance (9.7 +/- 1.5 to 4.8 +/- 1.4 ml/min) and increased urine osmolality (Uosmol; 71 +/- 6 to 115 +/- 15 mosmol/kgH2O); 5 pg.min-1.kg-1 elicited pronounced antidiuresis (14.4 +/- 0.9 to 0.9 +/- 0.3 ml/min) with maximal Uosmol of 621 +/- 95 mosmol/kg.	Water	129-134	arginine vasopressin	Homo sapiens	0-3
2378427-2	1990	The present study describes alterations in brain CRF neuronal systems that accompanied the voluntary high consumption of ethanol by Wistar rats presented with a free choice between 6% ethanol and tap water.	Water	200-205	nuclear RNA export factor 1	Rattus norvegicus	196-199
2383553-0	1990	Identification and localization of bound internal water in the solution structure of interleukin 1 beta by heteronuclear three-dimensional 1H rotating-frame Overhauser 15N-1H multiple quantum coherence NMR spectroscopy.	Water	50-55	interleukin 1 beta	Homo sapiens	85-103
2383553-1	1990	The presence and location of bound internal water molecules in the solution structure of interleukin 1 beta have been investigated by means of three-dimensional 1H rotating-frame Overhauser 1H-15N multiple quantum coherence spectroscopy (ROESY-HMQC).	Water	44-49	interleukin 1 beta	Homo sapiens	89-107
2383553-4	1990	By this means, the problems that prevent, in all but a very few limited cases, the interpretation, identification, and assignment of ROE peaks between NH protons and water in a 2D 1H-1H ROESY spectrum of a large protein such as interleukin 1 beta, namely, extensive NH chemical shift degeneracy and ROE peaks obscured by much stronger chemical exchange peaks, are completely circumvented.	Water	166-171	interleukin 1 beta	Homo sapiens	228-246
2383553-8	1990	209, 779-791], the results can be attributed to 11 water molecules that are involved in interactions bridging hydrogen-bonding interactions with backbone amide and carbonyl groups which stabilize the 3-fold pseudosymmetric topology of interleukin 1 beta and thus constitute an integral part of the protein structure in solution.	Water	51-56	interleukin 1 beta	Homo sapiens	235-253
2253582-0	1990	Acute decrease in vitellogenin synthesis by deprivation of food and water in laying hens.	Water	68-73	vitellogenin 2	Gallus gallus	18-30
2133180-5	1990	Taking a value of 1.00 for F absorption from sodium fluoride (NaF) in water, relative values of 0.58 and 0.32 were obtained for tea ingestion on a fasting stomach, and together with solid food, respectively.	Water	70-75	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
2133180-7	1990	Through another bioavailability experiment it was shown that the absorption of F (from MFP) in milk, is as high as that of F (from NaF) in water.	Water	139-144	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
2347488-0	1990	Prolactin cell activity and sodium balance in the acid-tolerant mudminnow Umbra pygmaea in acid and neutral water.	Water	108-113	prolactin	Sus scrofa	0-9
2347488-1	1990	In East-American mudminnows, obtained from lakes and bogs of different water pH levels, prolactin cell size and ultrastructure reflect higher secretory activity in neutral water than in water of pH 3.5-6.5.	Water	172-177	prolactin	Sus scrofa	88-97
2347488-1	1990	In East-American mudminnows, obtained from lakes and bogs of different water pH levels, prolactin cell size and ultrastructure reflect higher secretory activity in neutral water than in water of pH 3.5-6.5.	Water	172-177	prolactin	Sus scrofa	88-97
2347488-2	1990	This contrasts with observations on other species in which prolactin cell activity is higher at low water pH.	Water	100-105	prolactin	Sus scrofa	59-68
2347488-3	1990	Laboratory experiments involving acute exposure of mudminnows from pH 5.5 for 48 hr to different pH levels showed that prolactin secretion increased in water below pH 3 and above pH 6.5, which could be correlated with losses of blood electrolytes.	Water	152-157	prolactin	Sus scrofa	119-128
2347488-5	1990	Acclimation of fish for 5 to 6 months to either pH 4.5 or 7.2 confirmed that prolactin cell activity, as estimated with ultrastructural morphometry, was significantly higher in water of neutral pH than of pH 4.5.	Water	177-182	prolactin	Sus scrofa	77-86
2347488-9	1990	The reduction of Na+ efflux at pH 7.0 is in line with increased secretion of prolactin since this hormone is known to limit the branchial permeability to water and ions, including Na+.	Water	154-159	prolactin	Sus scrofa	77-86
2360714-2	1990	When human serum albumin is present, it is bound to the sensor and shields the fluorescent label from the solvent water, and a significant increase in the label fluorescence results.	Water	114-119	albumin	Homo sapiens	11-24
2140025-7	1990	The decreases in renal water and solute excretion in response to atriopeptin could be accounted for by the decrease in GFR, since there were no significant changes in fractional water or solute excretion.	Water	23-28	natriuretic peptide A	Homo sapiens	65-76
2188439-2	1990	This class of agents effectively inhibits the conversion of angiotensin I to the active vasoconstrictor angiotensin II, a hormone that also promotes, via aldosterone stimulation, increased sodium and water retention.	Water	200-205	angiotensinogen	Homo sapiens	60-73
2188439-2	1990	This class of agents effectively inhibits the conversion of angiotensin I to the active vasoconstrictor angiotensin II, a hormone that also promotes, via aldosterone stimulation, increased sodium and water retention.	Water	200-205	angiotensinogen	Homo sapiens	104-118
2185149-1	1990	Angiotensin II has recently been shown to exert potent control over sodium and water absorption in the proximal convoluted tubule.	Water	79-84	angiotensinogen	Homo sapiens	0-14
2376549-1	1990	Extraction of several nitrogen-containing pesticides from water on solid-phase C18 cartridges was rapid and accurate.	Water	58-63	Bardet-Biedl syndrome 9	Homo sapiens	79-82
2143212-1	1990	The protein moiety of Lp[a] consisting of apoB and apo[a] covalently linked to each other, once freed of lipids by delipidation at pH 8.0 with mixtures of diethyl ether and ethanol, is freely water-soluble at pH values above 6.4.	Water	192-197	apolipoprotein B	Homo sapiens	42-46
2143212-2	1990	This is in contrast to apoB which, if prepared by similar delipidation techniques, is only soluble at alkaline pH, indicating that the coupling of the carbohydrate-rich apo[a] to apoB confers water solubility to this apolipoprotein that it does not possess on its own.	Water	192-197	apolipoprotein B	Homo sapiens	179-183
2349271-4	1990	Angiotensin II reduced the intake of 6% alcohol and stimulated the intake of water similarly in both GVX and sham groups.	Water	77-82	angiotensinogen	Rattus norvegicus	0-14
2349271-7	1990	Angiotensin II decreased 6% alcohol intake and increased water intake similarly in both groups.	Water	57-62	angiotensinogen	Rattus norvegicus	0-14
2343162-4	1990	Vasopressin and desmopressin reduced water intake, plasma osmolality and plasma Na+ concentration similarly.	Water	37-42	arginine vasopressin	Rattus norvegicus	0-11
2191538-5	1990	However, degradation of the native Chr A and intermediates below 47 kDa could be prevented by extraction directly from intact CG, notably in cold or boiling distilled water.	Water	167-172	chromogranin A	Bos taurus	35-40
2327423-9	1990	Plasma vasopressin, measured in 11 of 22 patients as well as in six others not subjected to water loading, was detectable despite hypo-osmolality in 16 of 17.	Water	92-97	arginine vasopressin	Homo sapiens	7-18
2327423-10	1990	Vasopressin levels declined after water loading, from 1.85 +/- 1.32 to 0.77 +/- 0.25 pg/mL (p less than 0.05).	Water	34-39	arginine vasopressin	Homo sapiens	0-11
2345198-9	1990	Chilled drinking water lowered respiration rates and body temperatures and increased feed intake and milk yield.	Water	17-22	Weaning weight-maternal milk	Bos taurus	101-105
2360994-1	1990	A 2D NMR NOESY spectrum of integral CaM in water(148 residues) reveals a series of downfield-shifted crosspeaks stemming from the NH protons of the Ca2(+)-binding loops III and IV.	Water	43-48	calmodulin 1	Homo sapiens	36-39
2361004-4	1990	The GROMOS force field and the SPC model for water are shown to give an accurate theoretical account of the experimental data.	Water	45-50	proline rich protein gene cluster	Homo sapiens	31-34
2179419-7	1990	It was concluded that accelerated epithelization underneath the highly water vapor permeable polyetherurethane film dressing is associated with the presence of a gelatinous coagulum containing fibrin(ogen) and fibronectin.	Water	71-76	fibronectin 1	Homo sapiens	210-221
2187283-8	1990	In light of these data, mechanisms in which H2O is used to promote the C-10-C-19 bond cleavage or those in which the conversion of the 19-oxoandrostenedione into estrogen is considered to occur via the sequence -CHO----(-)CH(OH)2----estrogen are eliminated.	Water	44-47	homeobox C10	Homo sapiens	71-75
2334946-8	1990	For both measures of oxytocin and vasopressin mRNA levels, maximum-likelihood estimation indicated that this model adequately described empirical findings obtained from rats drinking tap water or salt water.	Water	187-192	arginine vasopressin	Rattus norvegicus	34-45
2168725-1	1990	The isolated and water-soluble complex of subunits I and II (core proteins) of ubiquinone:cytochrome c reductase from Neurospora mitochondria forms filaments below pH 6.0.	Water	17-22	cytochrome c, somatic	Homo sapiens	90-102
2139185-5	1990	Water intake induced by AII was attenuated by coadministration of ANP.	Water	0-5	angiotensinogen	Rattus norvegicus	24-27
2139185-9	1990	Water intake induced by AII infusion was attenuated by coadministration of ANP.	Water	0-5	angiotensinogen	Rattus norvegicus	24-27
2139185-10	1990	Taken together, these experiments demonstrate that, in contrast to the antagonistic interaction of ANP and AII on water intake, the peptides affect reproductive hormone secretion in the same direction and, under particular experimental conditions, display additive effects in stimulating LH and inhibiting prolactin release.	Water	114-119	angiotensinogen	Rattus norvegicus	107-110
2190928-8	1990	The water intake and pressor responses to intracerebroventricular angiotensin II (100 pmol) were inhibited by intracerebroventricular IMI (25 or 50 nmol) in conscious Sprague-Dawley rats.	Water	4-9	angiotensinogen	Rattus norvegicus	66-80
2143248-1	1990	To determine the effect of pregnancy on the plasma beta-endorphin response to exercise in the water, 12 women were tested during the 15th, 25th, and 35th wk of pregnancy and 10 wk post partum.	Water	94-99	proopiomelanocortin	Homo sapiens	51-65
2372541-0	1990	Estimation of disk membrane lateral pressure and molecular area of rhodopsin by the measurement of its orientation at the nitrogen-water interface from an ellipsometric study.	Water	131-136	rhodopsin	Homo sapiens	67-76
2372541-4	1990	The orientation of rhodopsin at the nitrogen-water interface was determined by using ellipsometry, which can measure the thickness of the film.	Water	45-50	rhodopsin	Homo sapiens	19-28
2337196-1	1990	In fresh-water rainbow trout, Oncorhynchus mykiss (formerly called Salmo gairdneri), experimentally induced mild hypercalcemia results in release of immunoreactive stanniocalcin from the corpuscles of Stannius (CS) and stimulated synthetic and releasing activities of the glands as measured in vitro.	Water	9-14	stanniocalcin	Oncorhynchus mykiss	164-177
1694105-2	1990	After prolonged administration of 2% sodium chloride as drinking water (salt-loading), the treatment increased the levels of VP, OXY, TH, GAL, DYN and CCK mRNA in the PVN and SON.	Water	65-70	arginine vasopressin	Rattus norvegicus	125-127
1694105-2	1990	After prolonged administration of 2% sodium chloride as drinking water (salt-loading), the treatment increased the levels of VP, OXY, TH, GAL, DYN and CCK mRNA in the PVN and SON.	Water	65-70	galanin and GMAP prepropeptide	Rattus norvegicus	138-141
2139879-1	1990	To examine a possible role for atrial natriuretic peptide (ANP) in water and sodium metabolism disturbances associated with abnormal vasopressin (AVP) secretion, we measured plasma ANP concentrations in 15 patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and in 17 patients with central diabetes insipidus (DI).	Water	67-72	natriuretic peptide A	Homo sapiens	59-62
2139879-3	1990	When hyponatremia was corrected by water restriction or demeclocycline administration, plasma ANP levels decreased significantly and fell into the normal range (12.5 +/- 4.3 pmol/L).	Water	35-40	natriuretic peptide A	Homo sapiens	94-97
2163414-3	1990	However, the magnitude of the increase in mean arterial pressure was significantly lower in the DOCA-hypertensive rats than in the two groups of rats drinking tap water and 1% NaCl after 4 and 6 weeks, but there was no significant difference after 2 weeks.	Water	163-168	nuclear RNA export factor 1	Rattus norvegicus	159-162
2163414-5	1990	However, the extent of the fall in renal blood flow was reduced in the DOCA-hypertensive rats compared with the control rats drinking tap water.	Water	138-143	nuclear RNA export factor 1	Rattus norvegicus	134-137
2116072-1	1990	To elucidate the role of antidiuretic hormone (ADH) on water and electrolyte balance in patients with asthmatic attacks, urinary arginine vasopressin (AVP) was assayed in 28 asthmatic patients.	Water	55-60	arginine vasopressin	Homo sapiens	47-50
1691384-0	1990	Hypotensive effects of angiotensin II analogues and angiotensin converting enzyme inhibitors in water-deprived Brattleboro rats.	Water	96-101	angiotensin I converting enzyme	Rattus norvegicus	52-81
2338532-0	1990	Vasopressin responses to hypoxia in conscious rats: interaction with water restriction.	Water	69-74	arginine vasopressin	Rattus norvegicus	0-11
2338532-1	1990	The purpose of this study was to determine the effect of water restriction on the vasopressin response to hypoxia in conscious Long-Evans rats.	Water	57-62	arginine vasopressin	Rattus norvegicus	82-93
2338532-6	1990	Hypoxia led to a very small and transient increase in vasopressin in the water-replete rats.	Water	73-78	arginine vasopressin	Rattus norvegicus	54-65
2338532-7	1990	The combination of hypoxia and water restriction led to a greatly augmented vasopressin response at 1 h (60 +/- 16 pmol/l); this response was also not sustained.	Water	31-36	arginine vasopressin	Rattus norvegicus	76-87
2338532-9	1990	Water restriction, hypoxia and water restriction plus hypoxia all led to decreased pituitary vasopressin content.	Water	0-5	arginine vasopressin	Rattus norvegicus	93-104
2338532-9	1990	Water restriction, hypoxia and water restriction plus hypoxia all led to decreased pituitary vasopressin content.	Water	31-36	arginine vasopressin	Rattus norvegicus	93-104
2338532-10	1990	We conclude that the vasopressin response to hypoxia in conscious rats is small and transient, and that concomitant water restriction augments the vasopressin response to acute but not chronic hypoxia.	Water	116-121	arginine vasopressin	Rattus norvegicus	147-158
2406266-9	1990	CD studies provided evidence that histatin 5 and the longer fragments, C16, N16, and C14 preferred alpha-helical conformations in non-aqueous solvents such as trifluoroethanol and methanol, while in water and pH 7.4 phosphate buffers, they favored random coil structures.	Water	199-204	histatin 3	Homo sapiens	34-44
2138237-3	1990	ANP increased NaCl excretion, fractional lithium excretion (FELi) and decreased diluting segment reabsorption estimated from free water clearance.	Water	130-135	natriuretic peptide A	Homo sapiens	0-3
2362587-0	1990	[The effect of structural-chemical characteristics of water-soluble polyelectrolyte complexes of ovalbumin on their immunological properties].	Water	54-59	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	97-106
2138727-7	1990	These results suggest that elevated plasma AVP level may be related with pulmonary abnormalities and that atrial natriuretic factor may hence compensate the water retention resulted from the functionally activated AVP in the early stage of BPD.	Water	157-162	arginine vasopressin	Homo sapiens	214-217
2140208-0	1990	The effect of fluorescent humic substances existing in the well water of Blackfoot disease endemic areas in Taiwan on prothrombin time and activated partial thromboplastin time in vitro.	Water	64-69	coagulation factor II, thrombin	Homo sapiens	118-129
2253582-6	1990	On day 3 the circulating vitellogenin concentrations, measured by a newly established RIA system, was markedly decreased by deprivation of food and water to 22% of the pretreatment level.	Water	148-153	vitellogenin 2	Gallus gallus	25-37
2253582-13	1990	Thus, these results demonstrated for the first time that the decrease in egg production induced by deprivation of food and water closely related to the decrease in vitellogenin synthesis as well as gonadal and pituitary functions.	Water	123-128	vitellogenin 2	Gallus gallus	164-176
1689289-9	1990	Raman spectra of SP in water indicates that SP near 30 mM forms an ensemble of structures in water that is distinct from completely unfolded peptide and from the aggregated beta-sheet form observed in saline solutions.	Water	23-28	tachykinin precursor 1	Homo sapiens	17-19
1689289-9	1990	Raman spectra of SP in water indicates that SP near 30 mM forms an ensemble of structures in water that is distinct from completely unfolded peptide and from the aggregated beta-sheet form observed in saline solutions.	Water	23-28	tachykinin precursor 1	Homo sapiens	44-46
1689289-9	1990	Raman spectra of SP in water indicates that SP near 30 mM forms an ensemble of structures in water that is distinct from completely unfolded peptide and from the aggregated beta-sheet form observed in saline solutions.	Water	93-98	tachykinin precursor 1	Homo sapiens	44-46
2178449-3	1990	The inhibitory effect of 100 mg/kg CA on water-to-food ratio was prevented by a dipsogenically subthreshold subcutaneous dose (5 micrograms/kg) of ANG II.	Water	41-46	angiotensinogen	Rattus norvegicus	147-153
2154994-3	1990	Cardiac taurine levels were reduced by half in rats given tap water containing a beta-amino transport inhibitor, beta-alanine.	Water	62-67	nuclear RNA export factor 1	Rattus norvegicus	58-61
2314632-0	1990	Vasopressin mRNA in parvocellular neurons of the rat suprachiasmatic nucleus exhibits increased poly (A) tail length following water deprivation.	Water	127-132	arginine vasopressin	Rattus norvegicus	0-11
2155002-7	1990	Insulin may increase absorption of sodium in the diluting segment of the distal nephron with consequent water retention.	Water	104-109	insulin	Homo sapiens	0-7
2137703-4	1990	ANP infusion into essential hypertensive patients increased the urinary excretion of water by 125%, Na by 205%, Hct by 4.2% and plasma total protein (TP) by 5.2% (each P less than .001).	Water	85-90	natriuretic peptide A	Homo sapiens	0-3
2337634-0	1990	[Effects of continuous infusion of vasopressin on circadian rhythms of food and water intake, urine output and electrolyte excretion in Brattleboro rats].	Water	80-85	arginine vasopressin	Rattus norvegicus	35-46
2137988-1	1990	Acute plasma volume reduction by atrial natriuretic peptide (ANP) may be mediated, at least in part, by increased exchange vessel water conductivity (Lp).	Water	130-135	natriuretic peptide A	Homo sapiens	33-59
2137988-1	1990	Acute plasma volume reduction by atrial natriuretic peptide (ANP) may be mediated, at least in part, by increased exchange vessel water conductivity (Lp).	Water	130-135	natriuretic peptide A	Homo sapiens	61-64
1692742-1	1990	The catalytic function of catalase and its peroxidatic activity during tetramethylbenzidine (TMB) oxidation by cumene hydroperoxide were studied in reversed micelles of Aerosol OT (AOT) in octane relative to the [H2O]/[AOT] ratio and the initial catalase concentration.	Water	213-216	catalase	Homo sapiens	26-34
1688888-0	1990	Angiotensin converting enzyme inhibition ameliorates glomerular filtration of macromolecules and water and lessens glomerular injury in the rat.	Water	97-102	angiotensin I converting enzyme	Rattus norvegicus	0-29
2298864-7	1990	In two patients who showed mild to moderate hyponatremia in the basal state and mild urinary diluting defect during water loading, plasma AVP was appropriately suppressed in each case.	Water	116-121	arginine vasopressin	Homo sapiens	138-141
2309887-0	1990	Apical membrane vesicles of ADH-stimulated toad bladder are highly water permeable.	Water	67-72	arginine vasopressin	Homo sapiens	28-31
2309887-10	1990	We conclude that these vesicles are highly permeable to water, and this is consistent with their postulated function of retrieving water channels that have been inserted into the apical membrane in response to ADH.	Water	56-61	arginine vasopressin	Homo sapiens	210-213
2163402-1	1990	Seven well-resolved signals could be observed in the field lower than 9.5 ppm in the 1H-NMR spectrum of the H2O solution of cyclic AMP receptor protein (CRP).	Water	108-111	C-reactive protein	Homo sapiens	124-151
2163402-1	1990	Seven well-resolved signals could be observed in the field lower than 9.5 ppm in the 1H-NMR spectrum of the H2O solution of cyclic AMP receptor protein (CRP).	Water	108-111	C-reactive protein	Homo sapiens	153-156
2106755-1	1990	The renin angiotensin system is an important system for the regulation of blood pressure and salt and water homeostasis.	Water	102-107	renin	Homo sapiens	4-9
2282064-1	1990	Treatment of cancer patients with disseminating malignancy using human recombinant interleukin-2 (rIL-2) is usually complicated by some adverse effects such as hypotension, an increase in vascular permeability and water retention due to the so-called "capillary leak syndrome".	Water	214-219	interleukin 2	Homo sapiens	83-96
2161258-1	1990	Interaction of low-molecular ligands (LML) isolated from blood serum albumin (SA) and serum proteins leads to higher T1 values for water protons compared with those observed in LML-free solutions, although the total amount of bound water increases.	Water	131-136	albumin	Homo sapiens	63-81
2161258-1	1990	Interaction of low-molecular ligands (LML) isolated from blood serum albumin (SA) and serum proteins leads to higher T1 values for water protons compared with those observed in LML-free solutions, although the total amount of bound water increases.	Water	232-237	albumin	Homo sapiens	63-81
2147380-8	1990	CSF-ANP may be of great importance in the regulation of water and ion content of central nervous system and probably liquor formation.	Water	56-61	natriuretic peptide A	Homo sapiens	4-7
2118717-12	1990	considerably decreased the SAP; Edema formation measured by water and Na+ content 24 hr after trauma was then reduced.	Water	60-65	amyloid P component, serum	Rattus norvegicus	27-30
2161258-2	1990	The latter was revealed by low-temperature NMR spectroscopy, as well as by the amount of water sorbed on SA + LML at a relative humidity P/Ps greater than 0.7.	Water	89-94	albumin	Homo sapiens	105-107
2147579-3	1990	This moderate increase in ANF is not likely to be explained by hypervolemia and is associated with sodium and water retention rather than natriuresis and diuresis.	Water	110-115	natriuretic peptide A	Homo sapiens	26-29
2161258-3	1990	In the region 0.2 less than P/Ps less than 0.6 the amount of SA + LML-sorbed water decreased, as compared with that in SA indicating that the oppositely charged groups of LML screen some charged groups of the protein.	Water	77-82	albumin	Homo sapiens	61-63
2344458-1	1990	An electrochemical system of cytochrome P-450 reduction in the presence of the water-soluble redox carrier methylviologen has been developed.	Water	79-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	29-45
2191853-2	1990	In patients with moderate to severe heart failure, therapeutic interventions incorporating diuretics, digoxin and selected vasodilators, specifically angiotensin-converting enzyme (ACE) inhibitors, are designed to correct pathophysiological mechanisms such as left ventricular dysfunction, excessive vasoconstriction and renal reabsorption of sodium and water.	Water	354-359	angiotensin I converting enzyme	Homo sapiens	150-179
2257720-9	1990	Redistribution of intrarenal blood flow with increased medullary flow, in addition, will antagonize the hydroosmotic effect of vasopressin, thus resulting in a rise in free-water clearance.	Water	173-178	arginine vasopressin	Homo sapiens	127-138
2090377-4	1990	Catalase effects the breakdown of H2O2 to O2 and H2O and offers protection against the toxic effects of oxygen radicals.	Water	34-37	catalase	Mus musculus	0-8
2111763-1	1990	Two tissue-specific water-soluble antigens AG1 and AG2 are revealed in immunobiochemical analysis of human squamous epithelium extract.	Water	20-25	NBPF member 10	Homo sapiens	43-46
2159399-3	1990	When compared with water-injected oocytes (controls), an increase in Ca2(+) channels was not detected until postnatal day 7.	Water	19-24	carbonic anhydrase 2	Mus musculus	69-72
2191853-2	1990	In patients with moderate to severe heart failure, therapeutic interventions incorporating diuretics, digoxin and selected vasodilators, specifically angiotensin-converting enzyme (ACE) inhibitors, are designed to correct pathophysiological mechanisms such as left ventricular dysfunction, excessive vasoconstriction and renal reabsorption of sodium and water.	Water	354-359	angiotensin I converting enzyme	Homo sapiens	181-184
2149337-2	1990	Twenty minutes head-out water immersion in a supine position in a thermo-neutral water bath attenuated the increase in PV induced by 20 min in a supine position in air, but increased the mean plasma [ANF] from 32.0 pg.ml-1, SEM 5.1 to 53.3 pg.ml-1, SEM 3.6 and decreased the mean plasma [AVP] from 1.4 pg.ml-1, SEM 0.1 to 0.9 pg.ml-1, SEM 0.04.	Water	24-29	natriuretic peptide A	Homo sapiens	200-204
1981183-5	1990	Plasma GH increased significantly (p less than 0.01) under DH after 2 and 3 h of exercise; this increase was prevented by rehydration with water, AISO and NISO.	Water	139-144	growth hormone 1	Homo sapiens	7-9
1981183-11	1990	It is concluded that progressive rehydration with water is sufficient to prevent the exercise-induced increase in plasma GH.	Water	50-55	growth hormone 1	Homo sapiens	121-123
2149337-2	1990	Twenty minutes head-out water immersion in a supine position in a thermo-neutral water bath attenuated the increase in PV induced by 20 min in a supine position in air, but increased the mean plasma [ANF] from 32.0 pg.ml-1, SEM 5.1 to 53.3 pg.ml-1, SEM 3.6 and decreased the mean plasma [AVP] from 1.4 pg.ml-1, SEM 0.1 to 0.9 pg.ml-1, SEM 0.04.	Water	81-86	natriuretic peptide A	Homo sapiens	200-204
2165464-5	1990	[Lys5] NKA(4-10) is a water soluble NK-2 potent agonist.	Water	22-27	tachykinin precursor 1	Homo sapiens	7-10
2347321-10	1990	We hypothesize that immersion in water caused prolactin levels to decline.	Water	33-38	prolactin	Homo sapiens	46-55
2165464-5	1990	[Lys5] NKA(4-10) is a water soluble NK-2 potent agonist.	Water	22-27	tachykinin precursor 1	Homo sapiens	36-40
2190994-8	1990	Conversely, vasopressin, which stimulates absorption of Na+ and water across colorectal epithelium, leads to a small increase in intercellular spaces in the monolayer.	Water	64-69	arginine vasopressin	Homo sapiens	12-23
2104396-2	1990	In recent years, the use of a sensitive radioimmunoassay for plasma vasopressin has implicated the role of nonosmotic vasopressin release in the water retention of these edematous disorders.	Water	145-150	arginine vasopressin	Homo sapiens	68-79
2104396-2	1990	In recent years, the use of a sensitive radioimmunoassay for plasma vasopressin has implicated the role of nonosmotic vasopressin release in the water retention of these edematous disorders.	Water	145-150	arginine vasopressin	Homo sapiens	118-129
2104396-10	1990	The slower response to restoring EABV involves vasopressin-mediated water retention and aldosterone-mediated sodium retention.	Water	68-73	arginine vasopressin	Homo sapiens	47-58
2115856-1	1990	Growth hormone-releasing hormone, GHRH(1-44), was administered intranasally to 16 healthy young adult male volunteers in a placebo-controlled study using a dose of 1,000 micrograms dissolved in two different solvent vehicles: water alone and water with the surface tension-lowering agent Tween 80 (0.12%).	Water	242-247	growth hormone releasing hormone	Homo sapiens	0-32
2210986-0	1990	Water immersion induced alterations of plasma vasopressin levels and activity of the renin-angiotensin-aldosterone system in noninflammatory acute renal failure and end-stage renal failure.	Water	0-5	arginine vasopressin	Homo sapiens	46-57
2210986-0	1990	Water immersion induced alterations of plasma vasopressin levels and activity of the renin-angiotensin-aldosterone system in noninflammatory acute renal failure and end-stage renal failure.	Water	0-5	renin	Homo sapiens	85-90
2210986-1	1990	UNLABELLED: Water immersion (WI) induced alterations of plasma renin activity (PRA), plasma aldosterone (Aldo), vasopressin (AVP), sodium and potassium concentrations and plasma volume (PV) were examined in 12 patients with noninflammatory acute renal failure (NARF) in the anuric/oliguric phase, in 20 patients with chronic renal failure (CRF) and in 15 healthy subjects.	Water	12-17	renin	Homo sapiens	63-68
2210986-1	1990	UNLABELLED: Water immersion (WI) induced alterations of plasma renin activity (PRA), plasma aldosterone (Aldo), vasopressin (AVP), sodium and potassium concentrations and plasma volume (PV) were examined in 12 patients with noninflammatory acute renal failure (NARF) in the anuric/oliguric phase, in 20 patients with chronic renal failure (CRF) and in 15 healthy subjects.	Water	12-17	arginine vasopressin	Homo sapiens	112-123
2137185-2	1990	This characteristic of the medullary circulation plays an important role in the kidney"s ability to excrete a dilute or concentrated urine in concert with changes in water and sodium transport in the distal nephron secondary to the action of vasopressin, prostaglandins, the renal nerves, and other hormones without significant other renal hemodynamic changes.	Water	166-171	arginine vasopressin	Homo sapiens	242-253
2136743-1	1990	Arginine vasopressin (AVP) and atrial natriuretic peptide (ANP) have important influences on water and electrolyte metabolism, and studies on the interactions between these hormones may have important implications.	Water	93-98	arginine vasopressin	Homo sapiens	9-20
2136743-1	1990	Arginine vasopressin (AVP) and atrial natriuretic peptide (ANP) have important influences on water and electrolyte metabolism, and studies on the interactions between these hormones may have important implications.	Water	93-98	arginine vasopressin	Homo sapiens	22-25
2273635-1	1990	Thermally dehydrated rats were given isotonic KCl, NaCl solution, or tap water ad libitum for 17 h and the differences of the restoration rate in fluid and cation were compared between the groups to elucidate the effect of Na+ and K+ ions on the replacement of each body fluid compartment during rehydration.	Water	73-78	nuclear RNA export factor 1	Rattus norvegicus	69-72
2248733-2	1990	The intravenous injection of MCP induced dose-related increases in plasma VP levels in water-loaded rats.	Water	87-92	arginine vasopressin	Rattus norvegicus	74-76
2151394-1	1990	In 6 heart transplant patients [HTP] and in 10 healthy subjects the influence of water immersion [WI] on blood levels of glucose, insulin and atrial natriuretic peptide [ANP] were studied.	Water	81-86	natriuretic peptide A	Homo sapiens	170-173
2151394-2	1990	HTP showed significantly higher baseline ANP levels and a reduced response of ANP to water immersion as compared with normals.	Water	85-90	natriuretic peptide A	Homo sapiens	78-81
1966626-4	1990	The attenuation in transplant recipients of the well-documented suppression of plasma renin activity during water immersion was probably due to a combination of factors, namely lack of renal innervation and an increase in circulating ANF.	Water	108-113	renin	Homo sapiens	86-91
2118391-0	1990	[An immunochemical analysis of the induction of cytochrome P-450 isoforms in the liver of fresh-water fishes by 3-methylcholanthrene, beta-naphthoflavone and aroclor 1254].	Water	96-101	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	48-64
1966626-4	1990	The attenuation in transplant recipients of the well-documented suppression of plasma renin activity during water immersion was probably due to a combination of factors, namely lack of renal innervation and an increase in circulating ANF.	Water	108-113	natriuretic peptide A	Homo sapiens	234-237
2141389-0	1990	Change in renal tubular sodium and water handling during progression of polycystic kidney disease: relationship to atrial natriuretic peptide.	Water	35-40	natriuretic peptide A	Homo sapiens	115-141
2098068-2	1990	OA is a "weak" mucosal antigen and we could only induce intestinal anti-OA responses by intraperitoneal, primary injection of OA in water-in-oil emulsion and a mucosal booster with OA.	Water	132-137	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-2
2098068-2	1990	OA is a "weak" mucosal antigen and we could only induce intestinal anti-OA responses by intraperitoneal, primary injection of OA in water-in-oil emulsion and a mucosal booster with OA.	Water	132-137	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	72-74
2343089-4	1990	However, a hint at the group of halogenated hydrocarbons is only possible, if additional information about miscibility with water is accessible.	Water	124-129	histidine triad nucleotide binding protein 1	Homo sapiens	11-15
2151585-4	1990	With institution of 10 cm of H2O of PEEP all 7 patients had a significant (p less than 0.05) decrease in the circulating concentrations of pro ANFs 1-98, 31-67 and ANF.	Water	29-32	natriuretic peptide A	Homo sapiens	143-146
2098068-2	1990	OA is a "weak" mucosal antigen and we could only induce intestinal anti-OA responses by intraperitoneal, primary injection of OA in water-in-oil emulsion and a mucosal booster with OA.	Water	132-137	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	72-74
2098068-2	1990	OA is a "weak" mucosal antigen and we could only induce intestinal anti-OA responses by intraperitoneal, primary injection of OA in water-in-oil emulsion and a mucosal booster with OA.	Water	132-137	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	72-74
2238253-7	1990	Similar signals were received in the partly degassed water of the lithotripter tub.	Water	53-58	TUB bipartite transcription factor	Homo sapiens	79-82
2296770-1	1990	Although carbon tetrachloride (CCl4) is of concern as a drinking water contaminant, it has been necessary in most oral toxicity studies to give CCl4 in an oil vehicle due to its limited water solubility.	Water	65-70	C-C motif chemokine ligand 4	Rattus norvegicus	31-35
2296770-9	1990	Both the 10 and 25 mg/kg oral doses of CCl4 in water caused significant elevations in serum enzymes and hepatic centrolobular vacuolation.	Water	47-52	C-C motif chemokine ligand 4	Rattus norvegicus	39-43
2152706-0	1990	[Atriopeptin: a new hormone in water-salt regulation].	Water	31-36	natriuretic peptide A	Homo sapiens	1-12
2275025-0	1990	[Ultrastructural changes in the cells of the vasopressin-sensitive epithelia during the stimulation of water transport].	Water	103-108	arginine vasopressin	Homo sapiens	45-56
2389602-2	1990	The renin-angiotensin-aldosterone system was found to play a certain role in controlling the water-electrolyte balance in premature infants.	Water	93-98	renin	Homo sapiens	4-9
2275025-1	1990	The author"s own and literary data are reviewed on the ultrastructural changes in cells of tight epithelia at the stimulation of osmotic water flows by vasopressin.	Water	137-142	arginine vasopressin	Homo sapiens	152-163
2934736-0	1985	Atrial natriuretic factor inhibits dehydration- and angiotensin II-induced water intake in the conscious, unrestrained rat.	Water	75-80	angiotensinogen	Rattus norvegicus	52-66
2934736-2	1985	In general, these peptides, called atrial natriuretic factors (ANFs), oppose the actions of the water-conservatory peptides angiotensin II and vasopressin and are released from the heart in response to atrial stretch as a consequence of increased venous return.	Water	96-101	angiotensinogen	Rattus norvegicus	124-138
2934736-2	1985	In general, these peptides, called atrial natriuretic factors (ANFs), oppose the actions of the water-conservatory peptides angiotensin II and vasopressin and are released from the heart in response to atrial stretch as a consequence of increased venous return.	Water	96-101	arginine vasopressin	Rattus norvegicus	143-154
2934736-6	1985	Water intake induced by central infusion of angiotensin II (9.6 and 25 pmol) in normally hydrated rats was significantly inhibited by prior infusion of 2.0 nmol of ANF.	Water	0-5	angiotensinogen	Rattus norvegicus	44-58
2934736-7	1985	Water intake induced by higher doses of angiotensin II was not altered significantly by prior infusion of ANF.	Water	0-5	angiotensinogen	Rattus norvegicus	40-54
33774820-8	2021	The effect of thaw depth on sap flow has implications for seasonal water-use patterns and warming impacts on tundra ecohydrology.	Water	67-72	SH2 domain containing 1A	Homo sapiens	28-31
33799262-1	2021	Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy (ATR-FTIR), in combination with chemometrics, was explored as a rapid method of detecting sugar adulteration in coconut water.	Water	189-194	ATR serine/threonine kinase	Homo sapiens	70-73
7307046-0	1981	[Radioimmunoassay of plasma and urine arginine-vasopressin in the diagnosis of water and osmotic balance disorders (author"s transl)].	Water	79-84	arginine vasopressin	Homo sapiens	47-58
33766377-7	2021	Thus, the synthesized MKa@4%CB can be a promising adsorbent in effectively removing Pb(II) and Cd(II) from water.	Water	107-112	submaxillary gland androgen regulated protein 3B	Homo sapiens	84-90
33033908-1	2021	Vitamin C (Vit C) is an ideal antioxidant as it is easily available, water soluble, very potent, least toxic, regenerates other antioxidants particularly Vit E, and acts as a cofactor for different enzymes.	Water	69-74	vitrin	Homo sapiens	0-3
33971470-8	2021	The NO3- content is highest in Cl type water, followed by SO4 type and HCO3 type water.	Water	39-44	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
33939414-13	2021	There is a good linear correlation, with a slope of 0.74, between the values of DeltaG  and DeltaG  determined by electron valence bond (EVB) calculations to model deprotonation of dihydroxyacetone phosphate (DHAP) in water and when bound to wild-type and variant forms of TIM to form the enediolate reaction intermediate.	Water	218-223	triosephosphate isomerase 1	Homo sapiens	273-276
33033908-1	2021	Vitamin C (Vit C) is an ideal antioxidant as it is easily available, water soluble, very potent, least toxic, regenerates other antioxidants particularly Vit E, and acts as a cofactor for different enzymes.	Water	69-74	vitrin	Homo sapiens	11-14
33766313-0	2021	Parts per trillion detection of heavy metals in as-is tap water using carbon nanotube microelectrodes.	Water	58-63	SEC14 like lipid binding 2	Homo sapiens	54-57
33766313-3	2021	To our knowledge, no electrochemical sensor for heavy metals with parts per trillion (PPT) limits of detection (LOD) in as-is tap water has been reported or developed.	Water	130-135	SEC14 like lipid binding 2	Homo sapiens	126-129
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Water	110-115	caveolin 1	Homo sapiens	329-339
33823595-0	2021	Dimethyl Sulfoxide-Free and Water-Soluble Fluorescent Probe for Detection of Bovine Serum Albumin Prepared by Ionic Co-assembly of Amphiphiles.	Water	28-33	albumin	Homo sapiens	84-97
33811441-3	2021	Specifically, a two-component gas mixture of water-soluble nitrogen and water-insoluble octafluoropropane as the gas phase are used in a microfluidic bubble generator.	Water	45-50	gastrin	Mus musculus	30-33
33811441-3	2021	Specifically, a two-component gas mixture of water-soluble nitrogen and water-insoluble octafluoropropane as the gas phase are used in a microfluidic bubble generator.	Water	72-77	gastrin	Mus musculus	30-33
33811441-4	2021	First, monodisperse microbubbles (MBs) with a classical microfluidic flow-focusing junction is generated, then the MBs shrink down to  100 nm diameter, due to the dissolution of the water-soluble components in the gas mixture.	Water	182-187	gastrin	Mus musculus	214-217
33811441-5	2021	The degree of shrinkage is controlled by tuning the ratio of water-soluble to water-insoluble gas components.	Water	78-83	gastrin	Mus musculus	94-97
33811938-4	2021	Recent studies in animal models of hepatocellular cholestasis show that the hepatic delivery of AdhAQP1, an adenovector encoding for the archetypical water channel human aquaporin-1 (hAQP1), improves bile secretion and restores to normal the elevated serum bile salt levels.	Water	150-155	aquaporin 1 (Colton blood group)	Homo sapiens	170-181
33811938-4	2021	Recent studies in animal models of hepatocellular cholestasis show that the hepatic delivery of AdhAQP1, an adenovector encoding for the archetypical water channel human aquaporin-1 (hAQP1), improves bile secretion and restores to normal the elevated serum bile salt levels.	Water	150-155	aquaporin 1 (Colton blood group)	Homo sapiens	98-103
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Water	110-115	aquaporin 1 (Colton blood group)	Homo sapiens	2-7
33825702-5	2021	These included the partial denaturation of KBP by air-water interfaces, protein aggregation resulting from carbon interaction and preferential orientation.	Water	54-59	kinesin family binding protein	Homo sapiens	43-46
33794341-1	2021	Water transport in the brain is tightly controlled by blood-brain-barrier (BBB) composed of capillary endothelial cells expressing AQP1/AQP11 and glial foot processes expressing AQP4.	Water	0-5	aquaporin 11	Mus musculus	136-141
33810181-6	2021	In comparison with a pure PSF membrane, GO/PSF composite membrane presented the higher hydrophilicity (water contact angles of 62.9 ) and more attractive permeability (178.5 L/m2h) by reducing the adhesion of hydrophobic foulants.	Water	103-108	insulin like growth factor binding protein 7	Homo sapiens	40-46
33819882-0	2021	Facile synthesis and characterization of polypyrrole - iron oxide - seaweed (PPy-Fe3O4-SW) nanocomposite and its exploration for adsorptive removal of Pb(II) from heavy metal bearing water.	Water	183-188	submaxillary gland androgen regulated protein 3B	Homo sapiens	151-157
33774793-3	2021	The aim of this paper was to classify the water quality and also predict potentially toxic anions (PTAs; e.g., Cl, SO4, HCO3, and NO3) and potentially toxic heavy metals (PTHMs; e.g., Fe, Zn, Ni, Cr, and Pb) in water resources in Ojoto and its surroundings, Nigeria.	Water	42-47	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
33807063-4	2021	For that purpose a pipe flow test rig is operated with a water-magnetite ferronanofluid.	Water	57-62	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	34-37
33775756-4	2021	Herein, we report a freestanding and self-adhesive bovine serum albumin/polypyrrole (BSA/PPy) hybrid film at the air/water interface.	Water	117-122	albumin	Homo sapiens	58-71
33804761-3	2021	Not only beta-CD, but also gamma-CD, tended to form a water-insoluble aggregate with Toc in aqueous media.	Water	54-59	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	9-16
33799551-2	2021	By grafting poly(2-dimethylaminoethyl methacrylate) (pDMAEMA) onto polyethylene (PP) membrane via ultraviolet (UV)-initiated polymerization, the obtained PP-g-pDMAEMA membrane presented positively in water and negatively in an alkaline buffer (pH 9.0), respectively.	Water	200-205	serglycin	Homo sapiens	154-158
33799840-0	2021	Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents.	Water	21-26	interleukin 6	Homo sapiens	72-85
33777930-4	2021	Aquaporin (AQP) 1, 3, and 5 are water channels that contribute to the progression of esophageal squamous cell carcinoma (ESCC) and GC.	Water	32-37	aquaporin 1 (Colton blood group)	Homo sapiens	0-27
33803313-13	2021	Meanwhile, the addition of hook steel fiber to the geopolymer concrete shows a higher density and water absorption compared to the sample with the addition of straight steel fibers.	Water	98-103	hook	Drosophila melanogaster	27-31
33800074-8	2021	This is the first study to show that mungbean water extract increased cellular glucose uptake and improved insulin sensitivity of insulin-resistant HepG2 cells through PTP-1B inhibition and modulating the expression of genes related to glucose metabolism.	Water	46-51	insulin	Homo sapiens	107-114
33803441-5	2021	Suppression of EAU derived in part from inhibiting pathogenic responses of Th17 cells while inducing expansion of regulatory lymphocytes that secrete IL-10 and/or IL-35 in the eye and peripheral lymphoid tissues.	Water	15-18	interleukin 10	Mus musculus	150-155
33800074-0	2021	Water Extract of Mungbean (Vigna radiata L.) Inhibits Protein Tyrosine Phosphatase-1B in Insulin-Resistant HepG2 Cells.	Water	0-5	insulin	Homo sapiens	89-96
33800074-1	2021	The present study aimed to investigate the effects of mungbean water extract (MWE) on insulin downstream signaling in insulin-resistant HepG2 cells.	Water	63-68	insulin	Homo sapiens	86-93
33762929-2	2020	To overcome these drawbacks, the sustained-release galantamine pamoate microspheres (GLT-PM-MS) were successfully developed using an oil/water emulsion solvent evaporation method in this study.	Water	137-142	solute carrier family 1 member 2	Rattus norvegicus	85-88
33800074-1	2021	The present study aimed to investigate the effects of mungbean water extract (MWE) on insulin downstream signaling in insulin-resistant HepG2 cells.	Water	63-68	insulin	Homo sapiens	118-125
33800074-8	2021	This is the first study to show that mungbean water extract increased cellular glucose uptake and improved insulin sensitivity of insulin-resistant HepG2 cells through PTP-1B inhibition and modulating the expression of genes related to glucose metabolism.	Water	46-51	insulin	Homo sapiens	130-137
32891005-12	2020	Most notably, the expression of the aquaporin family of genes (e.g. AQP1 and AQP9) were found to be significantly higher in the placentas of active women suggesting an adaptive response for the transport of water and glycerol in this population.	Water	207-212	aquaporin 1 (Colton blood group)	Homo sapiens	68-72
33486948-9	2021	The device was fabricated and its applicability has been demonstrated by delivering ~1.8 mL of water at a 10 +- 2 muLmin-1 flow rate at 2 V constant applied voltage over a period of 3 h. Such a wearable device can be programed to deliver model insulin or pain medication drugs for chronic diseases.	Water	95-100	insulin	Homo sapiens	244-251
33232115-3	2020	We have determined by NMR spectroscopy the structures of the transmembrane domain of amyloid precursor protein in TFE/water and compared it to that of four mutants: two FAD mutants, V44M and I45T, and the two diglycine hinge mutants, G38L and G38P.	Water	118-123	amyloid beta precursor protein	Homo sapiens	85-110
33941356-11	2021	Treatment with t-PA TBNI demonstrated superior clot dissolution at 30 minutes post-treatment (dissolved mm3: t-PA TBNI 625.4 +- 156.6 vs t-PA intravenously: 181.6 +- 94.3, P = .0003 vs distilled water TBNI 42.5 +- 33.0, P < .0001).	Water	195-200	plasminogen activator, tissue type	Sus scrofa	15-19
32890995-3	2020	Biological evaluation of these compounds revealed two compounds, 10 and 11, as new ATX enzyme inhibitors with potencies in the range of 218-220 nM and water solubility (>100 microg/mL), but with no LPAR1 inhibitory activity.	Water	151-156	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	83-86
33807998-3	2021	Aquaporin 1 (AQP1), as component of transmembrane-water-channel family proteins, has been documented in different human tumors and, recently, also in ovarian carcinoma.	Water	50-55	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
33807998-3	2021	Aquaporin 1 (AQP1), as component of transmembrane-water-channel family proteins, has been documented in different human tumors and, recently, also in ovarian carcinoma.	Water	50-55	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
33815893-0	2021	Electrocatalytic Water Oxidation with alpha-[Fe(mcp)(OTf)2] and Analogues.	Water	17-22	CD46 molecule	Homo sapiens	48-51
33807738-3	2021	Herein, a bismuth film-coated gold ultramicroelectrode array (BF-UMEA) was used for the detection of Pb(II) and Cd(II) in water samples via square wave anodic stripping voltammetry (SWASV).	Water	122-127	submaxillary gland androgen regulated protein 3B	Homo sapiens	101-107
33807738-8	2021	These results demonstrate the potential use of a BF-UMEA in SWASV for the trace quantification of Pb(II) and Cd(II) in water samples.	Water	119-124	submaxillary gland androgen regulated protein 3B	Homo sapiens	98-104
33589649-22	2021	Percepta"s main ingredient, PTI-00703 cat"s claw, has previously been shown to reduce brain amyloid plaques and Abeta 1-42/40 insoluble/soluble levels in brain (in plaque-producing transgenic mice) with marked concurrent memory improvements (shown by Morris water maze testing) (Snow et al.	Water	258-263	cathepsin S	Mus musculus	38-43
33232737-4	2021	We, however, previously demonstrated sex differences in the relationship between body weight and angiotensin II (AngII)-stimulated water intake.	Water	131-136	angiotensinogen	Rattus norvegicus	97-111
33232737-4	2021	We, however, previously demonstrated sex differences in the relationship between body weight and angiotensin II (AngII)-stimulated water intake.	Water	131-136	angiotensinogen	Rattus norvegicus	113-118
33232737-5	2021	Only after a pharmacological dose of AngII did water intake correlate with body weight, and only in males.	Water	47-52	angiotensinogen	Rattus norvegicus	37-42
33237239-12	2020	An application of topical NaF varnishes was effective in reducing TSL and enamel roughness after erosion challenges, being the CCP-ACP/NaF varnish more effective than NaF varnish and water after 3 days of erosion.	Water	183-188	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
32797882-7	2020	The analysis of natural water samples showed that total mercury levels ranged from concentrations lower than the method detection limit (2.0 ng L-1) to 10.9 ng L-1.	Water	24-29	L1 cell adhesion molecule	Homo sapiens	160-163
32797882-9	2020	To our knowledge, the developed method is the first ICP-MS method for the analysis of humic-rich natural water samples at ng L-1 concentrations without the need for hyphenated techniques or preconcentration procedures.	Water	105-110	L1 cell adhesion molecule	Homo sapiens	125-128
32891005-12	2020	Most notably, the expression of the aquaporin family of genes (e.g. AQP1 and AQP9) were found to be significantly higher in the placentas of active women suggesting an adaptive response for the transport of water and glycerol in this population.	Water	207-212	aquaporin 9	Homo sapiens	77-81
32629840-0	2020	Transferable Extended-Spectrum beta-Lactamase (ESBL) Plasmids in Enterobacteriaceae from Irrigation Water.	Water	100-105	EsbL	Escherichia coli	13-45
32860622-0	2021	Bioaccumulation and translocation of trace elements in soil-irrigation water-wheat in arid agricultural areas of Xin Jiang, China.	Water	71-76	xin actin binding repeat containing 1	Homo sapiens	113-116
32795534-8	2020	Our results further show an altered water-mediated H-bond network around the central transmembrane region of mutant rhodopsin, which is reminiscent of the active Meta-II state.	Water	36-41	rhodopsin	Homo sapiens	116-125
32795534-9	2020	This altered water-mediated H-bond network may cause thermal isomerization of the chromophore and facilitate rhodopsin dark activation.	Water	13-18	rhodopsin	Homo sapiens	109-118
25800359-4	2015	To better understand the parameters that may be responsible for this change, we report the systematic examination of a series of factors that can affect the behavior of the protein human serum albumin (HSA) when in contact with silicone oil in water.	Water	244-249	albumin	Homo sapiens	187-200
33774620-9	2020	In the short term, water supplementation in habitual low drinkers with high copeptin may reduce fasting glucose or glucagon, generating a proof of concept for the role of water supplementation in reducing incident metabolic disease.	Water	19-24	arginine vasopressin	Homo sapiens	76-84
33774620-9	2020	In the short term, water supplementation in habitual low drinkers with high copeptin may reduce fasting glucose or glucagon, generating a proof of concept for the role of water supplementation in reducing incident metabolic disease.	Water	19-24	glucagon	Homo sapiens	115-123
27016911-0	2016	A highly selective and picomolar level photoelectrochemical sensor for PCB 101 detection in environmental water samples.	Water	106-111	pyruvate carboxylase	Homo sapiens	71-74
27016911-1	2016	A highly selective and sensitive photoelectrochemical (PEC) sensor was fabricated for fast and convenient detection of PCB 101 in environmental water samples with a low detection limit of 1.0x10(-14)molL(-1) based on single crystalline TiO2 nanorods (NRs).	Water	144-149	pyruvate carboxylase	Homo sapiens	119-122
24605519-1	2014	Exposure to heat disturbs the homeostasis of body water, serum osmosis, and core temperature, resulting in the development of heat cramp, heat syncope, heat exhaustion, and heat stroke.	Water	50-55	cathelicidin antimicrobial peptide	Homo sapiens	131-136
25388559-2	2015	Surface application of aluminium (Al)-based water treatment residuals (Al-WTRs) to vegetated buffer strip (VBS) soils can enhance P removal from surface runoff during single runoff events.	Water	44-49	WTRS	Homo sapiens	74-78
25304826-0	2014	Intake of hot water-extracted apple protects against myocardial injury by inhibiting apoptosis in an ischemia/reperfusion rat model.	Water	14-19	alcohol dehydrogenase, iron containing, 1	Rattus norvegicus	10-13
25756677-7	2015	TLF was inversely related to water temperature (regression slope range: -1.57 to -2.50).	Water	29-34	TATA-box binding protein like 1	Homo sapiens	0-3
34875432-3	2022	Compared to hot water extraction (HE), UE-treated CSP led to a higher extraction efficiency and decreased average CSP molecular weight.	Water	16-21	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	114-117
22382020-2	2012	The amyloid-like fibrils are prepared in a two step procedure, where insulin and magnetic nanoparticles are mixed simply by grinding in the solid state, resulting in a water soluble hybrid material.	Water	168-173	insulin	Homo sapiens	69-76
21574399-0	2011	[Preparation of hydrophilic C18 material and its application for solid phase extraction of phenols in water].	Water	102-107	Bardet-Biedl syndrome 9	Homo sapiens	28-31
21574399-1	2011	A C18 monolithic material with a hydrophilic character was obtained by copolymerizing stearyl methacrylate (SMA) and a hydrophilic monomer poly (ethylene glycol) methyl ether methacrylate (PEGMEA) with porogen of 1-propanol/1,4-butanediol, and the resulting material was used for solid phase extraction (SPE) of phenols in water sample.	Water	323-328	Bardet-Biedl syndrome 9	Homo sapiens	2-5
12477195-1	2002	An interlaboratory study was conducted to assess the suitability of C18 solid-phase extraction disks to retain and ship different pesticides from water samples.	Water	146-151	Bardet-Biedl syndrome 9	Homo sapiens	68-71
9691010-0	1998	Decreased vasopressin-mediated renal water reabsorption in rats with compensated liver cirrhosis.	Water	37-42	arginine vasopressin	Rattus norvegicus	10-21
9691010-1	1998	Experiments were performed to investigate vasopressin type 2 receptor (V2)-mediated renal water reabsorption and the renal expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2) in cirrhotic rats with sodium retention but without ascites.	Water	163-168	arginine vasopressin	Rattus norvegicus	141-152
9691010-11	1998	Since daily urine flow rate was similar in cirrhotic and sham-operated rats, we suggest that non-vasopressin-mediated water reabsorption is increased in cirrhotic rats probably as a result of an increased corticomedullary gradient due to exaggerated NaCl reabsorption in the thick ascending limb of Henle"s loop.	Water	118-123	arginine vasopressin	Rattus norvegicus	97-108
1418126-9	1992	A negative correlation was observed between logarithm of urine AVP/Ccr ratio and free water clearance (p &lt; 0.01).	Water	86-91	arginine vasopressin	Homo sapiens	63-66
34619120-0	2022	Synthesis of gold nanoclusters-loaded lysozyme nanoparticles for ratiometric fluorescent detection of cyanide in tap water, cyanogenic glycoside-containing plants, and soils.	Water	117-122	lysozyme	Homo sapiens	38-46
23852584-2	2013	Disinfection for drinking water reduces the risk of pathogenic infection but may pose a chemical threat to human health due to disinfection residues and their by-products (DBP) when the organic and inorganic precursors are present in water.	Water	26-31	D-box binding PAR bZIP transcription factor	Homo sapiens	172-175
23852584-2	2013	Disinfection for drinking water reduces the risk of pathogenic infection but may pose a chemical threat to human health due to disinfection residues and their by-products (DBP) when the organic and inorganic precursors are present in water.	Water	234-239	D-box binding PAR bZIP transcription factor	Homo sapiens	172-175
34973200-1	2022	In order to effectively remove refractory bisphenol A (BPA) from water, a novel nitrogen doped organic porous functional azo linked polymer (ALP-p) was designed and prepared according to the physicochemical characteristics of propane linked to two phenol hydroxyl groups.	Water	65-70	alkaline phosphatase, placental	Homo sapiens	141-146
34929594-0	2022	The genotoxic potential of mixed nitrosamines in drinking water involves oxidative stress and Nrf2 activation.	Water	58-63	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
34865979-1	2022	A colorimetric gold nanoparticles (AuNPs)-based acetylcholinesterase (AChE) assay was designed for the first time to measure the concentration of parathion-methyl (PM) in lake water samples.	Water	176-181	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74
34931704-3	2022	The mechanism includes two major steps: the formation of the carbon-carbon bond and the removal of SiH3 /BF2 by water.	Water	112-117	forkhead box G1	Homo sapiens	105-108
34743794-1	2022	The green and efficient removal of nitrate (NO3-) in groundwater is a primary concern nowadays, and membrane capacitive deionization (MCDI) is an emerging technology for the removal of nitrate (NO3-) from water.	Water	205-210	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
34743794-1	2022	The green and efficient removal of nitrate (NO3-) in groundwater is a primary concern nowadays, and membrane capacitive deionization (MCDI) is an emerging technology for the removal of nitrate (NO3-) from water.	Water	205-210	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
34509486-1	2022	Pb(II) is a heavy metal that is a prominent contaminant in water contamination.	Water	59-64	submaxillary gland androgen regulated protein 3B	Homo sapiens	0-6
34871704-4	2022	Using the water maze test, we show that NPY (1 pmol) injected into the dorsal hippocampus impaired memory consolidation and that previous restraint stress (30 min) potentiates NPY effects, i.e. further impaired memory consolidation.	Water	10-15	neuropeptide Y	Rattus norvegicus	40-43
34871704-4	2022	Using the water maze test, we show that NPY (1 pmol) injected into the dorsal hippocampus impaired memory consolidation and that previous restraint stress (30 min) potentiates NPY effects, i.e. further impaired memory consolidation.	Water	10-15	neuropeptide Y	Rattus norvegicus	176-179
34626964-4	2022	Therefore, the resultant ZnO/Ag/beta-CD/PAN membrane displays splendid separation performance for oil/dye/water complex emulsions and high flux recovery (>90%).	Water	106-111	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	32-39
34879556-1	2022	In this study, a novel adsorbent made from kiwi branch biochar modified with Zn-Fe (KB/Zn-Fe) was compared with original biochar to the Pb(II)"s adsorptivity from waste water.	Water	169-174	submaxillary gland androgen regulated protein 3B	Homo sapiens	136-142
34688060-1	2022	A water-soluble, stable, simple and dual ligands (bovine serum albumin and L-histidine)-enhanced copper nanoclusters (BSA-CuNCs@L-His) was synthesized by one-step wet chemical method.	Water	2-7	albumin	Homo sapiens	57-70
34749258-6	2022	The in-situ time-dependent ATR-FTIR spectra provide evidence of water bonding to: the mu-OH group, the carboxylate anion COO- in 2,5-FDCA2- linker, oxygen atom in the furan ring of the linker, and the C-C and C-H bonds of the furan ring of the linker.	Water	64-69	ATR serine/threonine kinase	Homo sapiens	27-30
34749258-7	2022	Then, we conduct mechanistic and kinetic study of sorption of water vapor on MIL-160(Al) in air using the combination of two complementary in-situ time-dependent methods: the ATR-FTIR spectroscopy and gravimetric analysis.	Water	62-67	ATR serine/threonine kinase	Homo sapiens	175-178
34749258-9	2022	Chemical kinetics of water sorption on MIL-160(Al) follows a pseudo-first order rate law and it is consistent with dynamics and timescale revealed by in-situ time-dependent ATR-FTIR.	Water	21-26	ATR serine/threonine kinase	Homo sapiens	173-176
34488091-9	2022	In the final step, Pt-Pd-CdO/SWCNTs/ds-DNA/GE has been successfully utilized for the monitoring of cyanazine herbicide in food and water samples.	Water	131-136	cell adhesion associated, oncogene regulated	Homo sapiens	25-28
34627746-6	2022	AQP1 is mainly a water channel and thus is thought to be involved in the response to hyper-osmotic stress by efflux of water during hyperglycemia.	Water	17-22	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
34627746-6	2022	AQP1 is mainly a water channel and thus is thought to be involved in the response to hyper-osmotic stress by efflux of water during hyperglycemia.	Water	119-124	aquaporin 1 (Colton blood group)	Homo sapiens	0-4
34662568-3	2022	For chain segments at the beginning of the hydrocarbon region, (alpha2)-values are markedly restricted and temperature independent in DPPC with the lowest water content, whereas they increase with temperature in the low and fully hydrated bilayers, particularly at the highest temperatures.	Water	155-160	glycoprotein hormone subunit alpha 2	Homo sapiens	64-70
34687684-2	2022	In this study, we used TiO2-supported Pd catalysts to selectively hydrogenate the CC bonds in the Adda moiety, achieving rapid detoxification of MC-LR in water under ambient conditions.	Water	154-159	adducin 1	Homo sapiens	98-102
34920220-0	2022	KHCO3 activated biochar supporting MgO for Pb(II) and Cd(II) adsorption from water: Experimental study and DFT calculation analysis.	Water	77-82	submaxillary gland androgen regulated protein 3B	Homo sapiens	43-49
34973384-4	2022	Here, we collected water samples from an oxic urban river (Xin"an River, China; annual mean dissolved oxygen concentration was 9.91 +- 1.99 mg L-1) with a stony riverbed containing very little organic sediment.	Water	19-24	xin actin binding repeat containing 1	Homo sapiens	59-62
34883381-8	2022	This work illustrates Fe(VI) could remove BP-1 in water environments efficiently, and the newly proposed dioxygen transfer mechanism herein may contribute to the development of Fe(VI) chemistry.	Water	50-55	BP1	Homo sapiens	42-46
34749145-5	2022	In addition, the Nb2O5/g-C3N4 heterojunction possesses a large surface area, which contributes to the interfacial contact between photocatalyst and water.	Water	148-153	NBPF member 1	Homo sapiens	17-24
34774314-0	2022	rGO decorated ZnO/CdO heterojunction as a photoanode for photoelectrochemical water splitting.	Water	78-83	cell adhesion associated, oncogene regulated	Homo sapiens	18-21
34626626-0	2022	Local fresh- and sea-water effects on fog occurrence.	Water	21-26	zinc finger protein, FOG family member 1	Homo sapiens	38-41
34626626-2	2022	Two essential prerequisites of fog formation are the presence of fog condensation nuclei and water in the atmosphere.	Water	93-98	zinc finger protein, FOG family member 1	Homo sapiens	31-34
34626626-3	2022	The aim of our study was to examine in detail how fog occurrence is influenced by water areas in the immediate vicinity of the fog observation site.	Water	82-87	zinc finger protein, FOG family member 1	Homo sapiens	50-53
34626626-3	2022	The aim of our study was to examine in detail how fog occurrence is influenced by water areas in the immediate vicinity of the fog observation site.	Water	82-87	zinc finger protein, FOG family member 1	Homo sapiens	127-130
34626626-6	2022	A radius of 9 km appeared to be the most influential when considering the water area in a circle around the fog observation station.	Water	74-79	zinc finger protein, FOG family member 1	Homo sapiens	108-111
34626626-7	2022	Based on our results, we concluded that (i) the water area in the vicinity of the station is a factor influencing fog occurrence, (ii) the water"s effect differs according to water type (freshwater or seawater proximity), and (iii) GIS-derived topographical indices are informative for the explanation of fog occurrence and their inclusion enhanced the fit of the models substantially.	Water	48-53	zinc finger protein, FOG family member 1	Homo sapiens	114-117
34626626-7	2022	Based on our results, we concluded that (i) the water area in the vicinity of the station is a factor influencing fog occurrence, (ii) the water"s effect differs according to water type (freshwater or seawater proximity), and (iii) GIS-derived topographical indices are informative for the explanation of fog occurrence and their inclusion enhanced the fit of the models substantially.	Water	48-53	zinc finger protein, FOG family member 1	Homo sapiens	305-308
34626626-7	2022	Based on our results, we concluded that (i) the water area in the vicinity of the station is a factor influencing fog occurrence, (ii) the water"s effect differs according to water type (freshwater or seawater proximity), and (iii) GIS-derived topographical indices are informative for the explanation of fog occurrence and their inclusion enhanced the fit of the models substantially.	Water	139-144	zinc finger protein, FOG family member 1	Homo sapiens	305-308
34627881-0	2022	Adsorption of serine at the anatase TiO2/water interface: A combined ATR-FTIR and DFT study.	Water	41-46	ATR serine/threonine kinase	Homo sapiens	69-72
34474358-0	2022	Cerium-doped MIL-101-NH2(Fe) as superior adsorbent for simultaneous capture of phosphate and As(V) from Yangzonghai coastal spring water.	Water	131-136	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	93-98
34474358-7	2022	FT-IR and XPS analyses showed that the main mechanism for the removal of phosphate and As(V) from water by 1Ce-MIL-101-NH2 was the formation of an Fe/CeOP inner complex through ligand complexation and electrostatic attraction.	Water	98-103	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	87-92
34474358-8	2022	Furthermore, 1Ce-MIL-101-NH2 exhibited high selectivity and excellent efficiency in removing phosphate and As(V) in contaminated spring water in the presence of competing anions; this further confirms the application potential of the novel adsorbent.	Water	136-141	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	107-112
34788938-2	2022	Biological reduction of Pb(II) to metallic Pb is an attractive method for the remediation of Pb(II)-contaminated water and sediments.	Water	113-118	submaxillary gland androgen regulated protein 3B	Homo sapiens	24-30
34788938-2	2022	Biological reduction of Pb(II) to metallic Pb is an attractive method for the remediation of Pb(II)-contaminated water and sediments.	Water	113-118	submaxillary gland androgen regulated protein 3B	Homo sapiens	93-99
34836709-9	2022	The water extract of WBG improved the imbalance in inflammation in TNF-alpha-stimulated RAW264.7 cells by regulating 179 differential genes.	Water	4-9	tumor necrosis factor	Mus musculus	67-76
34779902-4	2022	The adsorption of thrombin onto the sorbent was achieved within 30 min and the desorption was realized using 5.0 mL of acetonitrile/water (80/20, v/v).	Water	132-137	coagulation factor II, thrombin	Homo sapiens	18-26
34723386-10	2022	Overall, this work demonstrates engineered hLFABP is a useful platform for detection of PFAS in environmental water samples and highlights its ease of use and versatility in field applications.	Water	110-115	fatty acid binding protein 1	Homo sapiens	43-49
34798707-7	2022	On this basis, using bovine serum albumin (BSA) as a model, the effect of tribo-catalytic reaction on controlling proteins in water was studied by fluorescence excitation-emission matrix spectroscopy (3D EEM) and infrared microscope, and the transformation of proteins was further analyzed.	Water	126-131	albumin	Homo sapiens	28-41
34455318-2	2022	In this study, we encapsulated insulin and quercetin using a self-assembled water-in-oil-in-water (W/O/W) double emulsion.	Water	76-81	insulin	Homo sapiens	31-38
34455318-2	2022	In this study, we encapsulated insulin and quercetin using a self-assembled water-in-oil-in-water (W/O/W) double emulsion.	Water	92-97	insulin	Homo sapiens	31-38
34767646-0	2022	Evidence for distinct isotopic compositions of sap and tissue water in tree stems: consequences for plant water source identification.	Water	106-111	SH2 domain containing 1A	Homo sapiens	47-50
34955193-6	2022	Second, 611 chemicals that had been recommended as hazardous pollutants for various water bodies in previous literatures were summarized, and a dataset DHP for hazardous pollutants in water was obtained.	Water	184-189	dihydropyrimidinase	Homo sapiens	152-155
34955193-7	2022	Third, meta-analysis on these two datasets (DPR and DHP) was performed, a new dataset DHPR for hazardous pollutants in reclaimed water was established, including 265 candidates.	Water	129-134	dihydropyrimidinase	Homo sapiens	52-55
34955193-7	2022	Third, meta-analysis on these two datasets (DPR and DHP) was performed, a new dataset DHPR for hazardous pollutants in reclaimed water was established, including 265 candidates.	Water	129-134	quinoid dihydropteridine reductase	Homo sapiens	86-90
34955193-8	2022	Finally, 59 substances out of dataset DHPR were identified as priority pollutants for reclaimed water based on their recommendation frequency.	Water	96-101	quinoid dihydropteridine reductase	Homo sapiens	38-42
34767646-3	2022	Using a novel technique to extract selectively sap water from xylem conduits, we show that, in cut stems and potted plants, the isotopic composition of sap water reflects that of irrigation water, demonstrating unambiguously that no isotopic fractionation occurs during root water uptake or sap water extraction.	Water	51-56	SH2 domain containing 1A	Homo sapiens	47-50
34767646-3	2022	Using a novel technique to extract selectively sap water from xylem conduits, we show that, in cut stems and potted plants, the isotopic composition of sap water reflects that of irrigation water, demonstrating unambiguously that no isotopic fractionation occurs during root water uptake or sap water extraction.	Water	156-161	SH2 domain containing 1A	Homo sapiens	152-155
34767646-6	2022	Data collected at a riparian forest indicate that sap water matches best unbound soil water from depth below -70cm, while bulk stem and soil water differ markedly.	Water	54-59	SH2 domain containing 1A	Homo sapiens	50-53
34269936-4	2022	We present a case-control study designed to evaluate efficacy in reducing the risk of SAP between two swallowing screening tools, the classic water swallow test (WST) and a recently validated tool such as the GLOBE-3S (the Sapienza GLObal Bedside Evaluation of Swallowing after Stroke), which is a highly sensitive swallowing screening tool particularly accurate in detecting silent aspiration as well.	Water	142-147	SH2 domain containing 1A	Homo sapiens	86-89
34914911-3	2022	In this study, we made an attempt to elucidate the molecular mechanism of water transportation in AQP1 from walking catfish (Clarias batrachus), a model species capable of breathing in air and inhabits in challenging environments.	Water	74-79	aquaporin 1 (Colton blood group)	Homo sapiens	98-102
34808107-5	2022	Turning their attention to brain swelling caused by liver disease, Dr. Brusilow and colleagues developed the Osmotic Gliopathy Hypothesis to help explain the mechanism of ammonia toxicity, postulating that high ammonia drives glutamine synthetase in astrocytes to produce elevated levels of glutamine that act as a potent osmolyte, drawing water into the cell and causing cerebral edema.	Water	340-345	glutamate-ammonia ligase	Homo sapiens	226-246
34520830-0	2022	Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulation JAK2/STAT3-mediated iNOS expression.	Water	0-5	signal transducer and activator of transcription 3	Mus musculus	132-137
34520830-0	2022	Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulation JAK2/STAT3-mediated iNOS expression.	Water	0-5	nitric oxide synthase 2, inducible	Mus musculus	147-151
34914357-1	2022	Electrocatalytic nitrate (NO3-) reduction to N2 via atomic hydrogen (H*) is a promising approach for advanced water treatment.	Water	110-115	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
34579536-4	2022	Here we discuss these methodologies and show how they can be applied to understand the downstream effects of GPCR signaling, specifically looking at how the neurohypophyseal peptide hormone vasopressin, working through the V2 receptor and PKA activation, regulates the water channel aquaporin-2.	Water	269-274	arginine vasopressin	Homo sapiens	190-201
34936333-0	2022	Reactive Nitrogen Species Generated by Gas-Liquid Dielectric Barrier Discharge for Efficient Degradation of Perfluorooctanoic Acid from Water.	Water	136-141	PAXIP1 associated glutamate rich protein 1	Homo sapiens	39-42
34852210-3	2022	PON2 and PON3 are expressed in the aldosterone-sensitive distal nephron of the kidney and have been shown to negatively regulate expression of the epithelial sodium channel (ENaC), a trimeric ion channel that orchestrates salt and water homeostasis.	Water	231-236	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	174-178
34592449-0	2022	One-pot synthesis of Ca-based magnetic hydrochar derived from consecutive hydrothermal and pyrolysis processing of bamboo for high-performance scavenging of Pb(II) and tetracycline from water.	Water	186-191	submaxillary gland androgen regulated protein 3B	Homo sapiens	157-163
34592449-6	2022	Overall, the Ca-MBHC could be viewed as an excellent adsorbent for scavenging Pb(II) and tetracycline from water.	Water	107-112	submaxillary gland androgen regulated protein 3B	Homo sapiens	78-84
34687497-4	2022	FAS can be easily reproduced in zebrafish by exposing the embryos to different concentrations of ethanol in water.	Water	108-113	Fas cell surface death receptor	Danio rerio	0-3
34563777-4	2022	Herein, we predicted the human health risk of binary pollutant mixtures (i.e., binary combinations of As(III), Cd(II), Cr(VI), Pb(II) and F(I)) in water using in vitro biological assays and deep learning methods.	Water	147-152	submaxillary gland androgen regulated protein 3B	Homo sapiens	127-142
34303053-0	2022	Efficient removal of a low concentration of Pb(II), Fe(III) and Cu(II) from simulated drinking water by co-immobilization between low-dosages of metal-resistant/adapted fungus Penicillium janthinillum and graphene oxide and activated carbon.	Water	95-100	submaxillary gland androgen regulated protein 3B	Homo sapiens	44-50
34517237-3	2022	Economically, amongst many wastewater treatment approaches, adsorption is both cheap and environmentally friendly for removing Pb(II) ion from contaminated water.	Water	156-161	submaxillary gland androgen regulated protein 3B	Homo sapiens	127-133
34303907-0	2022	Using simple and easy water quality parameters to predict trihalomethane occurrence in tap water.	Water	22-27	SEC14 like lipid binding 2	Homo sapiens	87-90
34303907-0	2022	Using simple and easy water quality parameters to predict trihalomethane occurrence in tap water.	Water	91-96	SEC14 like lipid binding 2	Homo sapiens	87-90
34303907-4	2022	Yet current models could not be well applied into practice because of the improper dataset (e.g. not from real tap water) they used or involving the parameters that are difficult to measure or require expensive instruments.	Water	115-120	SEC14 like lipid binding 2	Homo sapiens	111-114
34303907-5	2022	In this study, four simple and easy water quality parameters (temperature, pH, UVA254 and Cl2) were used to predict trihalomethane (THMs) occurrence in tap water.	Water	36-41	SEC14 like lipid binding 2	Homo sapiens	152-155
34303907-5	2022	In this study, four simple and easy water quality parameters (temperature, pH, UVA254 and Cl2) were used to predict trihalomethane (THMs) occurrence in tap water.	Water	156-161	SEC14 like lipid binding 2	Homo sapiens	152-155
34303907-7	2022	64 observations from tap water samples were used to develop and test models.	Water	25-30	SEC14 like lipid binding 2	Homo sapiens	21-24
34347242-6	2022	In addition, the detection of RAAS-related genes (AGT gene in the liver, REN in the kidney, ACE in the lung) demonstrates that after using salt-contaminated water, the transcription levels of AGT, REN, and ACE rise significantly, and the concentration of angiotensin II (Ang II) also increases significantly.	Water	157-162	angiotensinogen	Gallus gallus	50-53
34923327-2	2022	Many samples (32%) are above or approaching the recommended level of NO3- for safe drinking water.	Water	92-97	NBL1, DAN family BMP antagonist	Homo sapiens	69-72
34923327-7	2022	The HQ > 1 indicates non-carcinogenic health risk due to consumption of high NO3- in drinking water.	Water	94-99	NBL1, DAN family BMP antagonist	Homo sapiens	77-80
34686957-2	2022	In recent years, beta-cyclodextrin (beta-CD)-based polymers and nanosystems have been extensively studied as adsorbents for the purpose of water purification.	Water	139-144	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	36-43
34347242-6	2022	In addition, the detection of RAAS-related genes (AGT gene in the liver, REN in the kidney, ACE in the lung) demonstrates that after using salt-contaminated water, the transcription levels of AGT, REN, and ACE rise significantly, and the concentration of angiotensin II (Ang II) also increases significantly.	Water	157-162	angiotensinogen	Gallus gallus	192-195
34212318-3	2022	beta-CD, which is normally insoluble in water, is used in demanding wastewater applications by being modified with the help of different agents to be water soluble or transformed into polymeric adsorbents as a result of co-polymerization via cross-linkers.	Water	40-45	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	0-7
34212318-3	2022	beta-CD, which is normally insoluble in water, is used in demanding wastewater applications by being modified with the help of different agents to be water soluble or transformed into polymeric adsorbents as a result of co-polymerization via cross-linkers.	Water	150-155	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	0-7
34864529-4	2022	We have studied the effect of ionizing radiation on the activity of MPO, as measured by the capacity retained by the enzyme to produce hypochlorous acid as reactive oxygen species after exposure to successive doses of solvated electrons, the strongest possible one-e- reducing agent in water.	Water	286-291	myeloperoxidase	Homo sapiens	68-71
34786723-11	2022	Ap-CS showed significantly higher water absorption, Ca release, lysozyme adsorption, and collagenase resistance than CS.	Water	34-39	APCS	Canis lupus familiaris	0-5
34498364-1	2022	Stomatal closure is an important process to prevent water loss in plants response to drought stress, which is finely modulated by ion channels together with their regulators in guard cells, especially the S-type anion channel AtSLAC1 in Arabidopsis.	Water	52-57	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	226-233
34880492-7	2022	The structures, together with molecular dynamics simulations and functional studies, define the architecture of SGLTs, uncover the mechanism of substrate binding and selectivity, and shed light on water permeability of SGLT1.	Water	197-202	solute carrier family 5 member 1	Homo sapiens	219-224
34635270-0	2022	A molecularly imprinted biosensor based on water-compatible and electroactive polymeric nanoparticles for lysozyme detection.	Water	43-48	lysozyme	Homo sapiens	106-114
34635270-1	2022	A molecularly imprinted biosensor for lysozyme based on the polymer nanoparticles self-assembled from water-soluble and electroactive poly (gamma-glutamic acid) modified with 3-aminothiophene copolymer were prepared.	Water	102-107	lysozyme	Homo sapiens	38-46
34635270-2	2022	The water-soluble copolymer made imprinting of lysozyme in aqueous solution possible and thus facilitated improvement of the activity of LYS.	Water	4-9	lysozyme	Homo sapiens	47-55
34966186-1	2021	Elevated copeptin, a surrogate marker of vasopressin, is linked to low water intake and increased diabetes risk.	Water	71-76	arginine vasopressin	Homo sapiens	9-17
34965587-0	2021	Age-Dependent Dose Due to Intake of 40K, 228Ra, 226Ra in Spring Water in Petra District, Jordan.	Water	64-69	renin binding protein	Homo sapiens	0-3
34964524-0	2022	Brain myelin water fraction is associated with APOE4 allele status in patients with cognitive impairment.	Water	13-18	apolipoprotein E	Homo sapiens	47-52
34966186-1	2021	Elevated copeptin, a surrogate marker of vasopressin, is linked to low water intake and increased diabetes risk.	Water	71-76	arginine vasopressin	Homo sapiens	41-52
34966186-2	2021	Water supplementation in habitual low-drinkers with high copeptin significantly lowers both fasting plasma (fp) copeptin and glucose.	Water	0-5	arginine vasopressin	Homo sapiens	57-65
34966186-2	2021	Water supplementation in habitual low-drinkers with high copeptin significantly lowers both fasting plasma (fp) copeptin and glucose.	Water	0-5	arginine vasopressin	Homo sapiens	112-120
34936181-1	2022	Fog collection can be a sustainable solution to water scarcity in many regions around the world.	Water	48-53	zinc finger protein, FOG family member 1	Homo sapiens	0-3
34961483-15	2021	Environmental assessment showed that residents emptied their feces into a drainage channel connected to Well C. Drinking water from Well C was associated with illness (ORM-H = 21, 95% CI 4.6-93).	Water	121-126	orosomucoid 1	Homo sapiens	168-171
34961483-16	2021	Drinking water from a public tap (ORM-H = 0.07, 95% CI 0.014-0.304) was protective.	Water	9-14	orosomucoid 1	Homo sapiens	34-37
34878772-2	2021	The remarkable water adsorption and capture abilities of octopus tentacles inspired the construction of a novel TFC nanofiltration (NF) membrane with octopus arm-sucker morphology using carbon nanotubes (CNTs) and beta-cyclodextrin (beta-CD) during interfacial polymerization (IP).	Water	15-20	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	233-240
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	359-363
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	553-557
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	stomagen	Arabidopsis thaliana	747-752
34418621-9	2021	While the Zymo Quick-RNA Fecal/Soil Microbe MicroPrep Kit (also known as the Zymo Environ Water RNA Kit) only recovered approximately 73% (+-38%) SARS-CoV-2 RNA compared to the Zymo Quick-RNA Viral kit, it was the most time efficient kit to yield comparable results.	Water	90-95	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	54-57
34847328-1	2021	The structure, stability, and enzymatic activity of the adduct formed upon the reaction of the V-picolinato (pic) complex (VIVO(pic)2(H2O)), with an octahedral geometry and the water ligand in cis to the V O group, with the bovine pancreatic ribonuclease (RNase A) were studied.	Water	134-137	ribonuclease pancreatic	Bos taurus	256-263
34847328-1	2021	The structure, stability, and enzymatic activity of the adduct formed upon the reaction of the V-picolinato (pic) complex (VIVO(pic)2(H2O)), with an octahedral geometry and the water ligand in cis to the V O group, with the bovine pancreatic ribonuclease (RNase A) were studied.	Water	177-182	ribonuclease pancreatic	Bos taurus	256-263
34847328-3	2021	Crystallographic data demonstrate that the VIVO(pic)2 moiety coordinates the side chain of Glu111 of RNase A, by substituting the equatorial water molecule at acidic pH.	Water	141-146	ribonuclease pancreatic	Bos taurus	101-108
34927377-1	2022	Nitrate (NO 3 - ) as a common pollutant under groundwater causes drinking water safety problems and seriously endangers people"s health.	Water	74-79	NBL1, DAN family BMP antagonist	Homo sapiens	9-13
34946614-2	2021	S-nitrosocaptopril monohydrate (Cap-NO H2O) is a novel crystal form of S-nitrosocaptopril (Cap-NO), and is not only a nitric oxide (NO) donor, but also an angiotensin-converting enzyme inhibitor (ACEI).	Water	39-42	angiotensin I converting enzyme	Homo sapiens	155-184
34929145-0	2021	Surgical Management of Aortic Valve Endocarditis-The High-Water Mark?	Water	58-63	microtubule affinity regulating kinase 1	Homo sapiens	64-68
34303220-1	2021	A stable, water-soluble, heightened quantum yields (QYs) Au nanoclusters by the alliance between doping Ag and dual ligands (thiosalicylic acid and bovine serum albumin) (TSA/BSA-Au/AgNCs) was prepared using one-step wet chemical synthesis.	Water	10-15	albumin	Homo sapiens	155-168
34742842-7	2021	The findings herein reveal that P-CS is a promising adsorbent for the removal of anionic dyes such as AR88 or similar pollutants from water.	Water	134-139	PCS	Homo sapiens	32-36
34963947-1	2021	The current study pertains to the synthesis of an EDTA-functionalized beta-cyclodextrin-chitosan (beta-CD-CS-EDTA) composite via a two-step process for the adsorptive removal of toxic heavy metallic ions (i.e., Pb(II), Cu(II), and Ni(II)) and antibiotic micropollutant, i.e., ciprofloxacin (CIP), from water.	Water	302-307	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	98-105
34886821-4	2021	The level of SOD of subjects in high fluorine drinking water was low compared with those in normal areas.	Water	55-60	superoxide dismutase 1	Homo sapiens	13-16
34890091-2	2022	Here, we found that overexpression of a TaABFs-regulated PYL gene, TaPYL1-1B, exhibited higher ABA sensitivity, photosynthetic capacity, and water-use efficiency (WUE), all contributed to higher drought tolerance than that of wild-type plants.	Water	141-146	secreted frizzled related protein 4	Homo sapiens	57-60
34948707-2	2021	In this study, an adaptive population and water-food-energy (WFE) management framework (APRF) incorporating vulnerability assessment, uncertainty analysis, and systemic optimization methods is developed for optimizing the relationship between population development and WFE management (P-WFE) under combined policies.	Water	42-47	signal transducer and activator of transcription 3	Homo sapiens	88-92
34426342-1	2021	This review reports on the increasing interest in technical designs, calibration, and application of PIM-based devices in sample pre-treatment and passive sampling in environmental water monitoring from 2010 to 2021.	Water	181-186	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	101-104
34943069-3	2021	DPPH  was used as a reactivity model of reactive oxygen species and solubilized in water using beta-cyclodextrin (beta-CD).	Water	83-88	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	114-121
34817179-2	2021	In this work, properties of heptakis(2,6-O-dimethyl)-beta-cyclodextrin (DM-beta-CD) in vacuo and in water, as well as its ability to bind the antidepressant drug mianserin (MIA) in aqueous solution, are investigated computationally.	Water	100-105	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	75-82
34817179-6	2021	Both the B3LYP-GD2 and M062X-GD3 results show that all tested inclusion and noninclusion complexes of MIA:DM-beta-CD in stoichiometry 1:1 are stable in water.	Water	152-157	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	109-116
34818019-8	2021	The Csp2-H blue shift of Csp2-H...Z bonds in the halogenated aldehydes is converted into a red shift when H2O is replaced by a heavier analogue, such as H2S, H2Se, or H2Te.	Water	106-109	regulator of calcineurin 2	Homo sapiens	4-8
34818019-8	2021	The Csp2-H blue shift of Csp2-H...Z bonds in the halogenated aldehydes is converted into a red shift when H2O is replaced by a heavier analogue, such as H2S, H2Se, or H2Te.	Water	106-109	regulator of calcineurin 2	Homo sapiens	25-29
34947158-0	2021	Potential Application of Pin-to-Liquid Dielectric Barrier Discharge Structure in Decomposing Aqueous Phosphorus Compounds for Monitoring Water Quality.	Water	137-142	dynein light chain LC8-type 1	Homo sapiens	25-28
34947158-1	2021	Here, we proposed a pin-to-liquid dielectric barrier discharge (DBD) structure that used a water-containing vessel body as a dielectric barrier for the stable and effective treatment of aqueous solutions in an open atmosphere.	Water	91-96	dynein light chain LC8-type 1	Homo sapiens	20-23
34947158-4	2021	Moreover, we proposed that the pin-to-liquid DBD reactor could be used to decompose phosphorus compounds in water in the form of phosphate as a promising pretreatment method for monitoring total phosphorus in water.	Water	108-113	dynein light chain LC8-type 1	Homo sapiens	31-34
34947158-4	2021	Moreover, we proposed that the pin-to-liquid DBD reactor could be used to decompose phosphorus compounds in water in the form of phosphate as a promising pretreatment method for monitoring total phosphorus in water.	Water	209-214	dynein light chain LC8-type 1	Homo sapiens	31-34
34947158-5	2021	The decomposition of phosphorus compounds using the pin-to-liquid DBD reactor demonstrated excellent performance-comparable to the thermochemical pretreatment method-which could be a standard pretreatment method for decomposing phosphorus compounds in water.	Water	252-257	dynein light chain LC8-type 1	Homo sapiens	52-55
34917778-0	2021	The role of water in the reversibility of thermal denaturation of lysozyme in solid and liquid states.	Water	12-17	lysozyme	Homo sapiens	66-74
34917778-2	2021	We evaluated the reversibility of thermal unfolding of lysozyme with respect to the water content using a combination of thermodynamic and structural techniques such as differential scanning calorimetry, synchrotron small and wide-angle X-ray scattering (SWAXS) and Raman spectroscopy.	Water	84-89	lysozyme	Homo sapiens	55-63
34917778-7	2021	A phase diagram of thermal unfolding/denaturation in lysozyme - water system was constructed based on the experimental data.	Water	64-69	lysozyme	Homo sapiens	53-61
34876210-2	2021	Catalase, a peroxisomal enzyme, plays an important role in maintaining intracellular redox homeostasis by decomposing hydrogen peroxide to either water or oxygen that oxidize and provide fuel for cellular metabolism.	Water	146-151	catalase	Mus musculus	0-8
34926901-1	2021	Nitrate (NO3 -) contamination is becoming a major concern due to the negative effects of an excessive NO3 - presence in water which can have detrimental effects on human health.	Water	120-125	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
34870594-1	2021	The phosphorylation-activated anion channel CFTR is gated by an ATP hydrolysis cycle at its two cytosolic nucleotide binding domains, and is essential for epithelial salt-water transport.	Water	171-176	CF transmembrane conductance regulator	Homo sapiens	44-48
34899874-8	2021	Keywords were classified into five clusters, indicating the five main research focuses on CED studies: hydrological cycle, effects of climate change, carbon and water balance, productivity, and carbon-nitrogen-phosphorous coupling cycles.	Water	161-166	intraflagellar transport 122	Homo sapiens	90-93
34899874-10	2021	In future CED studies, basic themes (such as "water", "yield", and "salinity") and motor themes (such as "climate change", "sustainability", and "remote sensing") will be the focus of research on CED.	Water	46-51	intraflagellar transport 122	Homo sapiens	196-199
34917955-6	2021	SPs like SP-A and SP-D have antimicrobial activities providing a crucial first line of defense against infections in lungs whereas SP-B and SP-C are mainly involved in respiratory cycle and reduction of surface tension at air-water interface.	Water	226-231	surfactant protein C	Homo sapiens	140-144
34947629-3	2021	Herein, we report successful swelling of a graphene/PSS/PAH composite in a vapor atmosphere, and the relation with the mass fraction of water is uncovered.	Water	136-141	PSS	Homo sapiens	52-55
34788019-3	2021	Reaction of either PyAH or the pharmacophore-bearing PyAH ligand (L1H) with fac-(M(CO)3)+ core in water yielded the intermediate fac-(M(CO)3(PyA)(H2O)) complexes.	Water	98-103	FA complementation group C	Homo sapiens	76-79
34788019-3	2021	Reaction of either PyAH or the pharmacophore-bearing PyAH ligand (L1H) with fac-(M(CO)3)+ core in water yielded the intermediate fac-(M(CO)3(PyA)(H2O)) complexes.	Water	98-103	FA complementation group C	Homo sapiens	129-132
34788019-3	2021	Reaction of either PyAH or the pharmacophore-bearing PyAH ligand (L1H) with fac-(M(CO)3)+ core in water yielded the intermediate fac-(M(CO)3(PyA)(H2O)) complexes.	Water	146-149	FA complementation group C	Homo sapiens	76-79
34788019-3	2021	Reaction of either PyAH or the pharmacophore-bearing PyAH ligand (L1H) with fac-(M(CO)3)+ core in water yielded the intermediate fac-(M(CO)3(PyA)(H2O)) complexes.	Water	146-149	FA complementation group C	Homo sapiens	129-132
34926901-1	2021	Nitrate (NO3 -) contamination is becoming a major concern due to the negative effects of an excessive NO3 - presence in water which can have detrimental effects on human health.	Water	120-125	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
34926901-2	2021	Sensitive, real-time, low-cost, and portable measurement systems able to detect extremely low concentrations of NO3 - in water are thus becoming extremely important.	Water	121-126	NBL1, DAN family BMP antagonist	Homo sapiens	112-115
34926901-3	2021	In this work, we present a novel method to realize a low-cost and easy to fabricate amperometric sensor capable of detecting small concentrations of NO3 - in real water samples.	Water	163-168	NBL1, DAN family BMP antagonist	Homo sapiens	149-152
34926901-7	2021	The proposed sensors were also used to detect NO3 - in real samples, including tap and river water, through the standard addition method, and the results were compared with the outcomes of high-performance liquid chromatography (HPLC).	Water	93-98	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
34517785-3	2021	The results showed that recombinant serotonin transporter (SERT) messenger ribonucleic acid (mRNA) level of the constipation population fecal fluid gavage group and the relative expression level of SERT mRNA were 1.61 +- 0.08 and 1.49 +- 0.06, which were higher markedly than those of distilled water group (P < 0.05).	Water	295-300	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	36-57
34265040-6	2021	Studies assessing the effects of plant-based dietary components added to diet and/or water on uncoupling protein 1 (UCP1) expression in BAT and/or WAT were included.	Water	85-90	uncoupling protein 1	Rattus norvegicus	94-114
34432538-3	2021	In response to stimulation with the antidiuretic hormone, arginine vasopressin, aquaporin-2 containing vesicles fuse with the plasma membrane, which increases collecting duct water reabsorption and thus, urine concentration.	Water	175-180	arginine vasopressin	Homo sapiens	36-56
34432538-3	2021	In response to stimulation with the antidiuretic hormone, arginine vasopressin, aquaporin-2 containing vesicles fuse with the plasma membrane, which increases collecting duct water reabsorption and thus, urine concentration.	Water	175-180	arginine vasopressin	Homo sapiens	67-78
34152256-8	2021	However, observed in rats, the water content of the brain tissue of rats with increased miR-497 expression was reduced, and the neuronal apoptosis rate of the brain tissue was inhibited.	Water	31-36	microRNA 497	Rattus norvegicus	88-95
34700226-5	2021	The albumin/genipin bioglue is formed by simple mixing of bovine serum albumin (BSA) and genipin (GP) under a 35  C water bath for 24 h without further purification.	Water	116-121	albumin	Homo sapiens	4-11
34519633-0	2021	Special electromagnetic field-treated water and far-infrared radiation alleviates lipopolysaccharide-induced acute respiratory distress syndrome in rats by regulating haptoglobin.	Water	38-43	haptoglobin	Rattus norvegicus	167-178
34717965-9	2021	IGF-1 induced activation of YAP/TAZ, which resulted in improved cell viability in vitro, and reduced neurological deficits, brain water content, neuronal death and apoptosis, and cerebral infarct volume in vivo.	Water	130-135	Yes1 associated transcriptional regulator	Rattus norvegicus	28-31
34246937-11	2021	As 200 mug/L of bromide was added to the water, bromate concentration increased significantly and then decreased as H2O2/O3 (g/g) increased and more H2O2 would be needed for bromate control.	Water	41-46	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	116-123
34560942-2	2021	Copper nanoparticles immobilized-beta-cyclodextrin functionalized reduced graphene oxide (Cu/beta-CD/rGO) were successfully prepared as an efficient extractor of tetracycline (TC), oxytetracycline (OTC) and doxycycline (DC) antibiotics from different environmental water samples.	Water	265-270	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	93-100
34560942-7	2021	The Cu/beta-CD/rGO nanocomposite was applied for removing TCs from tap water and the Nile River water samples.	Water	71-76	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	7-14
34560942-7	2021	The Cu/beta-CD/rGO nanocomposite was applied for removing TCs from tap water and the Nile River water samples.	Water	96-101	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	7-14
34481349-0	2021	Two-dimensional BCN nanosheets self-assembled with hematite nanocrystals for sensitively detecting trace toxic Pb(II) ions in natural water.	Water	134-139	submaxillary gland androgen regulated protein 3B	Homo sapiens	111-117
34273081-1	2021	Nitrate (NO3-) contamination has become a dominant international problem in the aquatic environment, so identifying the sources and transformations of NO3- is the basis for improving water quality.	Water	183-188	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
34273081-1	2021	Nitrate (NO3-) contamination has become a dominant international problem in the aquatic environment, so identifying the sources and transformations of NO3- is the basis for improving water quality.	Water	183-188	NBL1, DAN family BMP antagonist	Homo sapiens	151-154
34537554-2	2021	Multiple analysis of crystal structures reveals the presence of W1, W2, and W3 water locations in the active site pocket of Mpro; W1 and W2 are unstable and are weakly bonded with protein in comparison to W3 of Mpro-native.	Water	79-84	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	124-128
34523520-4	2021	The released Cd concentrations in overlying water with nFe2O3@BC capping decreased by 1.6-11.0 times compared to those of BC capping, indicating nFe2O3@BC presented a higher capping efficiency.	Water	44-49	nuclear factor, erythroid 2	Homo sapiens	145-149
34523520-5	2021	Notably, the increases of acidity and disturbance intensity of overlying water weakened the capping efficiencies of nFe2O3@BC and BC.	Water	73-78	nuclear factor, erythroid 2	Homo sapiens	116-120
34926555-1	2021	The complex of soy protein isolate (SPI)/bamboo shoot protein concentrate (BPC) was developed to stabilize camellia oil-in-water (O/W) emulsions.	Water	123-128	chromogranin A	Homo sapiens	36-39
34967854-8	2021	Conclusions: Our data demonstrate the therapeutic effect of IL-38 on EAU, and suggest that the effect of IL-38 may be caused by dampening of the GM-CSF/IL-23R/IL-23 feedback loop between Th17 cells and APCs.	Water	69-72	interleukin 23 receptor	Mus musculus	152-158
34197988-6	2021	The larger lipid-water interfacial area provided by the DODAP self-assemblies at pH <= 4.5 allowed for an adequate encapsulation efficiency of LL-37, favouring the formation of vesicles in a concentration-dependent manner.	Water	17-22	cathelicidin antimicrobial peptide	Homo sapiens	143-148
34601164-3	2021	Herein we report the interaction of (Ru2(Ibp)4Cl) and of (Ru2(Ac)4(H2O)2)PF6 (Ac, acetate) with the 4-aminopyridine (4Apy) drug.	Water	67-70	DEF6 guanine nucleotide exchange factor	Homo sapiens	41-44
34601164-3	2021	Herein we report the interaction of (Ru2(Ibp)4Cl) and of (Ru2(Ac)4(H2O)2)PF6 (Ac, acetate) with the 4-aminopyridine (4Apy) drug.	Water	67-70	adenylate cyclase 4	Homo sapiens	57-66
33557644-1	2021	The aim of this study was to prepare and characterise inclusion complexes of a low water-soluble drug, mefenamic acid (MA), with beta-cyclodextrin (beta-CD).	Water	83-88	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	148-155
34748042-1	2021	Na+,K+-ATPase (NKA) is essential for maintenance of cellular and whole-body water and ion homeostasis.	Water	76-81	tachykinin precursor 1	Homo sapiens	0-13
34748042-1	2021	Na+,K+-ATPase (NKA) is essential for maintenance of cellular and whole-body water and ion homeostasis.	Water	76-81	tachykinin precursor 1	Homo sapiens	15-18
34537554-4	2021	Virtual screening is employed to find out best analogs of HCQ, molecular docking is used for water displacement from catalytic region of Mpro, and finally, MD simulations are conducted for validation of these findings.	Water	93-98	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	137-141
34191610-0	2021	Multidrug-Resistant Extended-Spectrum beta-Lactamase-Producing Escherichia coli Pathotypes in North Eastern Region of India: Backyard Small Ruminants-Human-Water Interface.	Water	156-161	EsbL	Escherichia coli	20-52
34673427-7	2021	The log BAF values of SCCP homologues (1.33-4.75) increased significantly with the increase of their logarithm octanol-water partition coefficients (log KOW) values, indicating that hydrophobicity is the major factor controlling the bioaccumulation of SCCPs.	Water	119-124	BAF nuclear assembly factor 1	Homo sapiens	8-11
34310496-0	2021	Energy Expenditure of a Male and Female Tennis Player during ATP/WTA and Grand Slam Events Measured by Doubly Labelled Water.	Water	119-124	signaling lymphocytic activation molecule family member 1	Homo sapiens	79-83
34600953-1	2021	Due to its low molecular weight and abundant functional groups, water-soluble lignin (WSL) is considered as a more potent antioxidant than traditional industrial lignin in biofields.	Water	64-69	tumor necrosis factor receptor superfamily, member 25	Mus musculus	86-89
34510301-0	2021	Deuterium-depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration.	Water	19-24	insulin	Homo sapiens	75-82
34510301-12	2021	Based on our experimental data, deuterium-depleted water could be used to treat patients with metabolic syndrome (MS) by increasing insulin sensitivity.	Water	51-56	insulin	Homo sapiens	132-139
34491405-1	2021	RATIONALE: Cd81 -/- (knockout) mice have previously been reported to have reduced cocaine preference and increased striatal dopamine content and dopamine turnover, but normal learning and memory in the Morris water maze.	Water	209-214	CD81 antigen	Mus musculus	11-15
34943879-2	2021	The GH/IGF1 system plays a key role in normal kidney development, glomerular hemodynamic regulation, as well as tubular water, sodium, phosphate, and calcium handling.	Water	120-125	insulin like growth factor 1	Homo sapiens	7-11
34779863-3	2021	In the present study, male Sprague-Dawley rats were treated with PM2.5 suspension for 12 weeks and/or fed with tap water containing an antioxidant tempol.	Water	115-120	nuclear RNA export factor 1	Rattus norvegicus	111-114
34884753-7	2021	Its binding to the vasopressin V2 receptor promotes AQP2 targeting to the apical membrane and thus enables water reabsorption.	Water	107-112	arginine vasopressin receptor 2	Homo sapiens	19-42
34767375-1	2021	Fog collection plays an important role in alleviating the global water shortage.	Water	65-70	zinc finger protein, FOG family member 1	Homo sapiens	0-3
34824221-2	2021	Integrated into membranes they use four electrons from cytochrome c molecules to reduce molecular oxygen (dioxygen) to water.	Water	119-124	cytochrome c, somatic	Homo sapiens	55-67
34887234-5	2021	The prediction was that treated water would result in increased cell proliferation, that more cells would enter the cell cycle growth phase, and that there would be increased expression of genes (NANOG, OCT4 and SOX2) associated with improved cell growth and decreased expression of genes (p16, p21, and p53) associated with a decline in cell growth.	Water	32-37	cyclin dependent kinase inhibitor 2A	Homo sapiens	290-293
34887234-5	2021	The prediction was that treated water would result in increased cell proliferation, that more cells would enter the cell cycle growth phase, and that there would be increased expression of genes (NANOG, OCT4 and SOX2) associated with improved cell growth and decreased expression of genes (p16, p21, and p53) associated with a decline in cell growth.	Water	32-37	tumor protein p53	Homo sapiens	304-307
34782902-7	2021	However, in contrast to what is observed upon pressurisation (~50 GPa), where the presence of the water counterions triggers methane ionisation and other reactions, methane molecules preserve their integrity up to the strongest field explored (i.e., 0.50 V A-1).	Water	98-103	glycophorin A (MNS blood group)	Homo sapiens	66-69
34885735-5	2021	The results showed that the prepared beta-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.	Water	154-159	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	37-44
34884463-1	2021	Lens water transport generates a hydrostatic pressure gradient that is regulated by a dual-feedback system that utilizes the mechanosensitive transient receptor potential vanilloid (TRPV) channels, TRPV1 and TRPV4, to sense changes in mechanical tension and extracellular osmolarity.	Water	5-10	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	198-203
34884463-8	2021	These reciprocal changes in TRPV1/4 membrane localization are consistent with the channels acting as mechanosensitive transducers of a dual-feedback pathway that regulates lens water transport.	Water	177-182	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	28-35
34767375-2	2021	Despite great progress in creating bionic surfaces to collect fog, water droplets still could adhere to the microscale hydrophilic region and reach the thermodynamic stable state before falling, which delays the transport of water and hinders the continuous fog collection.	Water	67-72	zinc finger protein, FOG family member 1	Homo sapiens	258-261
34767375-2	2021	Despite great progress in creating bionic surfaces to collect fog, water droplets still could adhere to the microscale hydrophilic region and reach the thermodynamic stable state before falling, which delays the transport of water and hinders the continuous fog collection.	Water	225-230	zinc finger protein, FOG family member 1	Homo sapiens	62-65
34795427-5	2021	Intriguingly, animals with a double-hit, i.e. injury and ApoE conditionally inactivated in astrocytes, demonstrated the most pronounced impairments in the hippocampal-dependent Morris water maze test, failing to exhibit spatial memory after both acquisition and reversal training trials.	Water	184-189	apolipoprotein E	Mus musculus	57-61
34830416-0	2021	Aquaporin-1 Facilitates Transmesothelial Water Permeability: In Vitro and Ex Vivo Evidence and Possible Implications in Peritoneal Dialysis.	Water	41-46	aquaporin 1 (Colton blood group)	Homo sapiens	0-11
34830416-1	2021	We previously showed that mesothelial cells in human peritoneum express the water channel aquaporin 1 (AQP1) at the plasma membrane, suggesting that, although in a non-physiological context, it may facilitate osmotic water exchange during peritoneal dialysis (PD).	Water	76-81	aquaporin 1 (Colton blood group)	Homo sapiens	103-107
34830416-1	2021	We previously showed that mesothelial cells in human peritoneum express the water channel aquaporin 1 (AQP1) at the plasma membrane, suggesting that, although in a non-physiological context, it may facilitate osmotic water exchange during peritoneal dialysis (PD).	Water	217-222	aquaporin 1 (Colton blood group)	Homo sapiens	103-107
34830416-8	2021	Real-time transmesothelial water flux, in response to an increase of osmolarity in the apical solution, indicated that, in the presence of AQP1, the rate of TEA+ dilution was up to four-fold higher than in its absence.	Water	27-32	aquaporin 1 (Colton blood group)	Homo sapiens	139-143
34792465-1	2021	Two neural circuits control the release of vasopressin in response to eating and drinking before there are any detectable changes in blood water levels.	Water	139-144	arginine vasopressin	Homo sapiens	43-54
34880830-0	2021	Apelin and Vasopressin: The Yin and Yang of Water Balance.	Water	44-49	apelin	Homo sapiens	0-6
34880830-0	2021	Apelin and Vasopressin: The Yin and Yang of Water Balance.	Water	44-49	arginine vasopressin	Homo sapiens	11-22
34880830-4	2021	In humans and rodents, if plasma osmolality is increased by hypertonic saline infusion/water deprivation or decreased by water loading, plasma vasopressin and apelin are conversely regulated to maintain body fluid homeostasis.	Water	121-126	arginine vasopressin	Homo sapiens	143-154
34783031-7	2022	Here, we orally treated SOD1G93A mice with Trimetazidine, solubilized in drinking water at a dose of 20 mg/kg, from disease onset.	Water	82-87	superoxide dismutase 1, soluble	Mus musculus	24-28
34869555-13	2021	Conclusion: Preoperative CHO and drinking water are associated with decreased levels of IL-6, IL-8, and TNF.	Water	42-47	interleukin 6	Homo sapiens	88-92
34869555-13	2021	Conclusion: Preoperative CHO and drinking water are associated with decreased levels of IL-6, IL-8, and TNF.	Water	42-47	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
34869555-13	2021	Conclusion: Preoperative CHO and drinking water are associated with decreased levels of IL-6, IL-8, and TNF.	Water	42-47	tumor necrosis factor	Homo sapiens	104-107
34746944-9	2021	It is found from our calculations that the first solvation shell of insulin is readily occupied by choline and geranate ions in the presence of water.	Water	144-149	insulin	Homo sapiens	68-75
34746944-10	2021	Moreover, the geranate ions strongly interacted with the water molecules and thereby, eliminating the intermolecular hydrogen bonding (H-bonding) interactions towards the insulin at 0.30-0.50 mole fraction of CAGE ILs.	Water	57-62	insulin	Homo sapiens	171-178
34746944-11	2021	The most desirable 0.30-0.50 mole fraction of CAGE invigorates water-mediated H-bonding interactions with geranate ions, which also enhances the electrostatic behavior around the vicinity of the insulin dimer.	Water	63-68	insulin	Homo sapiens	195-202
34791149-4	2022	Using a gravimetric platform, we show that IL20 maintained higher root water influx and gas exchange under drought stress, which supported a greater growth.	Water	71-76	interleukin 20	Homo sapiens	43-47
34821675-7	2021	By changing the water saturation of the continuous phase, the equation of state of lysozyme in solution was determined through the relation of the osmotic pressure between protein molecules and the volume fraction of protein inside the droplets.	Water	16-21	lysozyme	Homo sapiens	83-91
34791149-5	2022	Interestingly, the advantage of IL20 in root water influx and transpiration was expressed earlier during the daily diurnal cycle under lower VPD and therefore supported higher transpiration efficiency.	Water	45-50	interleukin 20	Homo sapiens	32-36
34358868-9	2021	In conclusion, the oxidative stress and inflammation response are closely correlated with cellular responses in THP-1 derived macrophages induced by water soluble components of PM2.5, and cell cycle dysregulation may play an important role in biological effects induced by organic components.	Water	149-154	GLI family zinc finger 2	Homo sapiens	112-117
34808511-8	2021	Water fluoride concentrations were positively associated with AChE and negatively associated with ChAT and ACh, trends were same for urinary fluoride except for ACh.	Water	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-66
34808511-10	2021	The mediation proportion by AChE between water fluoride and either developing DF or IQ < 120 was 15.7%.	Water	41-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-32
34420733-5	2021	The tight and water-separated ion pairs existed at w:IL-5:5 and w:IL-4:6 mixtures allow adequate ions to interact with starch to facilitate the disaggregation of starch.	Water	14-19	interleukin 4	Homo sapiens	66-70
34699174-1	2021	In this study, the novel application of ATR-FTIR spectroscopy and macro ATR-FTIR spectroscopic imaging overcame an analytical challenge in conservation science: the time-resolved, chemical, and spatial investigation of the reaction of inorganic treatments for stone conservation (ammonium oxalate, AmOx; ammonium phosphate, DAP) occurring in water-based solutions.	Water	342-347	ATR serine/threonine kinase	Homo sapiens	72-75
34767107-5	2021	Non-carcinogenic risk due to NO3- exposure through consumption of drinking water was assessed, and the associated zoning maps were presented using geographic information system (GIS).	Water	75-80	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
34605524-1	2021	From pasta to biological tissues to contact lenses, gel and gel-like materials inherently soften as they swell with water.	Water	116-121	solute carrier family 45 member 1	Homo sapiens	5-10
34420733-3	2021	Compared with pure water, existed hydrated free ions in w:IL-9:1 and w:IL-7:3 restrict starch-water interactions to disaggregate of starch, thus hampering gelatinization of starch.	Water	19-24	interleukin 7	Homo sapiens	71-75
34420733-3	2021	Compared with pure water, existed hydrated free ions in w:IL-9:1 and w:IL-7:3 restrict starch-water interactions to disaggregate of starch, thus hampering gelatinization of starch.	Water	94-99	interleukin 7	Homo sapiens	71-75
34702033-2	2021	Herein, the electric active CoII ion is selected to coordinate with redox-active S-rich tetrathiafulvalene (TTF) derivatives to create two TTF-Co-MOFs, formulated as (Co2(py-TTF-py)2(BDC)2) 2DMF H2O (TTF-Co-MOF 1) and (Co2(py-TTF-py)2(BPDC)2) 3DMF 3H2O (TTF-Co-MOF 2), where py-TTF-py = 2,6-bis(4"-pyridyl)tetrathiafulvalene, H2BDC = terephthalic acid, H2BPDC = biphenyl-4,4"-dicarboxylic acid, and DMF = N,N-dimethylformamide.	Water	195-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
34352479-1	2021	The increase in NO3- content in surface water caused by intensive mining activities in Huainan City, China, has attracted considerable attention owing to the deterioration of water quality and the degradation of ecosystems in recent years.	Water	40-45	NBL1, DAN family BMP antagonist	Homo sapiens	16-19
34352479-1	2021	The increase in NO3- content in surface water caused by intensive mining activities in Huainan City, China, has attracted considerable attention owing to the deterioration of water quality and the degradation of ecosystems in recent years.	Water	175-180	NBL1, DAN family BMP antagonist	Homo sapiens	16-19
34352479-10	2021	Therefore, NO3- in the surface water of the mining area primarily originates from chemical fertilizers and manure sewage.	Water	31-36	NBL1, DAN family BMP antagonist	Homo sapiens	11-14
34352479-12	2021	These findings highlight the value of classifying different types of surface water in tracing NO3- contamination sources, and provide relevant theoretical basis for tracing nitrate sources in other areas.	Water	77-82	NBL1, DAN family BMP antagonist	Homo sapiens	94-97
34827686-6	2021	In particular, protein unfolding is always prior to knot untying and starts preferentially from separation of two alpha-helices (alpha1 and alpha5), which protect the hydrophobic core consisting of beta-sheets (beta1-beta4) from exposure to water.	Water	241-246	BCL2 related protein A1	Homo sapiens	129-146
34755247-11	2022	CONCLUSIONS: A spatial relation of water diffusion, as measured by DW-MRI, and cellular proliferation, as measured by (18F)FLT PET, cannot be detected in the experimental datasets investigated in this study.	Water	35-40	fms related receptor tyrosine kinase 1	Homo sapiens	123-126
34700330-1	2021	Two luminescent Cd(II)-organic frameworks (Cd2(L1)(tdc)2(H2O))n (1) and (Cd(L2)0.5(tdc))n (2) (L1 = 1,5-bis(1-(pyridine-4-ylmethyl)-1H-benzo(d)imidazol-2-yl)pentane, L2 = 1,6-bis(1-(pyridine-4-ylmethyl)-1H-benzo(d)imidazol-2-yl)hexane, and H2tdc = 2,5-thiophenedicarboxylic acid) were hydrothermally synthesized and characterized.	Water	57-60	L1 cell adhesion molecule	Homo sapiens	43-49
34747561-3	2022	METHODS: Prothrombin time was determined, with a manual hook technique, in glass test tubes in a water bath at a controlled temperature.	Water	97-102	coagulation factor II, thrombin	Homo sapiens	9-20
34510664-0	2021	A Water-Soluble Peptoid Chelator that Can Remove Cu2+ from Amyloid-beta and Stop the Formation of Reactive Oxygen Species Associated with Alzheimer"s Disease.	Water	2-7	amyloid beta precursor protein	Homo sapiens	59-71
34510664-4	2021	Herein we describe P3, a water-soluble peptidomimetic chelator that selectively removes Cu(II) from Cu-Abeta in the presence of Zn and prevent the formation of ROS even in a reductive environment.	Water	25-30	amyloid beta precursor protein	Homo sapiens	103-108
34674526-0	2021	Structural Stability of Insulin Oligomers and Protein Association-Dissociation Processes: Free Energy Landscape and Universal Role of Water.	Water	134-139	insulin	Homo sapiens	24-31
34769501-1	2021	Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically associated with their regulatory role in reproduction, water homeostasis, and social behaviors.	Water	134-139	arginine vasopressin	Homo sapiens	18-29
34738875-2	2021	Experimentalists have identified the possibility of Cd(II) reducing the activity of human uracil DNA glycosylase (hUNG) by binding with the enzyme replacing the catalytic water molecule.	Water	171-176	uracil DNA glycosylase	Homo sapiens	90-112
34674526-3	2021	We focus on the solvation of the insulin monomer in water, stability and dissociation of its dimer, and structural integrity of the hexamer.	Water	52-57	insulin	Homo sapiens	33-40
34674526-5	2021	Ten water molecules inside the central cavity stabilize the structure of the insulin hexamer.	Water	4-9	insulin	Homo sapiens	77-84
34834279-3	2021	Here we aimed to analyse the structural properties of water in a sample of an aqueous solution of IFNgamma via terahertz time-domain spectroscopy (THz-TDS).	Water	54-59	interferon gamma	Homo sapiens	98-106
34469051-3	2021	The cognitive decline in patients with AD has been reported to be closely related to the deposition of amyloid-beta (Abeta) in the hippocampus of the brain, and the Morris water maze (MWM) test is a widely used method for assessing the behavior of animal models.	Water	172-177	amyloid beta precursor protein	Homo sapiens	103-115
34726676-1	2021	Herein a 1D Co(II) coordination polymer of formula (Co(eta1-L1)(eta2-L1)(py)2(H2O))n (CoCP) has been synthesised using the rigid H2L1 proligand, containing a long spacer bearing two triple bonds.	Water	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
34743518-2	2022	The enantiomeric excess (ee) of chiral (E)-isomer (1E) produced was a critical function of all the internal and external factors examined, in particular, the sensitizer structure and the solvent conditions, to afford (R)-1E in record-high ee"s of up to 67% upon sensitization with the meta-substituted beta-CD host in water and salt solutions but neither in 50% aqueous ethanol nor with the ortho- and para-substituted hosts.	Water	318-323	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	302-309
34469051-3	2021	The cognitive decline in patients with AD has been reported to be closely related to the deposition of amyloid-beta (Abeta) in the hippocampus of the brain, and the Morris water maze (MWM) test is a widely used method for assessing the behavior of animal models.	Water	172-177	amyloid beta precursor protein	Homo sapiens	117-122
34687821-9	2021	Meanwhile, C10 with a high stability in aquacultural water in immersion suppressed IHNV horizontal transmission by decreasing the viral loads in recipient fish.	Water	53-58	homeobox C10	Homo sapiens	11-14
34364573-1	2021	The purpose of this study was to use hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as a novel carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral bioavailability of poorly water-soluble dexibuprofen.	Water	200-205	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	73-80
34543987-2	2021	Arginine vasopressin (AVP) which is involve in the regulation of body osmotic system, body water content, blood pressure and plasma volume, that are highly disturbed in Covid-19 and linked with poor clinical outcomes.	Water	91-96	arginine vasopressin	Homo sapiens	9-20
34543987-2	2021	Arginine vasopressin (AVP) which is involve in the regulation of body osmotic system, body water content, blood pressure and plasma volume, that are highly disturbed in Covid-19 and linked with poor clinical outcomes.	Water	91-96	arginine vasopressin	Homo sapiens	22-25
34906039-1	2021	The effect of exogenous cytochrome c (cyt c) on kinetics of photoelectric responses (Deltapsi) of two types of photosystem II (PSII) core complexes (intact - PSII with active water-oxidizing complex and Mn-depleted complex) reconstituted into liposomes has been investigated by direct electrometric technique.	Water	175-180	cytochrome c, somatic	Homo sapiens	24-36
34906039-1	2021	The effect of exogenous cytochrome c (cyt c) on kinetics of photoelectric responses (Deltapsi) of two types of photosystem II (PSII) core complexes (intact - PSII with active water-oxidizing complex and Mn-depleted complex) reconstituted into liposomes has been investigated by direct electrometric technique.	Water	175-180	cytochrome c, somatic	Homo sapiens	38-43
34688406-1	2021	The calcium-sensing receptor (CaSR) is important in the skin, contributing to several epidermal functions, including differentiation, water permeability barrier repair, and wound healing.	Water	134-139	calcium sensing receptor	Homo sapiens	4-28
34688406-1	2021	The calcium-sensing receptor (CaSR) is important in the skin, contributing to several epidermal functions, including differentiation, water permeability barrier repair, and wound healing.	Water	134-139	calcium sensing receptor	Homo sapiens	30-34
34596809-0	2021	Recombinant water stress protein 1 (Re-WSP1) suppresses colon cancer cell growth through the miR-539/beta-catenin signaling pathway.	Water	12-17	microRNA 539	Homo sapiens	93-100
34652342-5	2021	Mice were fed sugar water (SUG; control) or TCW for a week and then subjected to 60 min of liver ischemia followed by reperfusion for 6 h. Plasma alanine transaminase levels, tissue damage, and mRNA levels of Nos2, Tnf, and Il6 were significantly lower in mice fed TCW prior to I/R.	Water	20-25	nitric oxide synthase 2, inducible	Mus musculus	209-213
34454183-13	2021	RESULTS: In in vivo experiments, NKILA significantly reduced cerebral infarction volume, brain water content and neurological score caused by MCAO/R.	Water	95-100	NF-kappaB interacting lncRNA	Homo sapiens	33-38
34725482-4	2021	Investigating environmental water, Escherichia coli, and human plasma extracts with HERMES, we achieved an increased biological specificity of MS2 scans, leading to improved mass spectral similarity scoring and identification rates when compared with a state-of-the-art data-dependent acquisition (DDA) approach.	Water	28-33	RNA binding protein, mRNA processing factor	Homo sapiens	84-90
34549505-6	2021	And the amorphous Co(II) component accelerates the water dissociation.	Water	51-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
34652342-5	2021	Mice were fed sugar water (SUG; control) or TCW for a week and then subjected to 60 min of liver ischemia followed by reperfusion for 6 h. Plasma alanine transaminase levels, tissue damage, and mRNA levels of Nos2, Tnf, and Il6 were significantly lower in mice fed TCW prior to I/R.	Water	20-25	tumor necrosis factor	Mus musculus	215-218
34652342-5	2021	Mice were fed sugar water (SUG; control) or TCW for a week and then subjected to 60 min of liver ischemia followed by reperfusion for 6 h. Plasma alanine transaminase levels, tissue damage, and mRNA levels of Nos2, Tnf, and Il6 were significantly lower in mice fed TCW prior to I/R.	Water	20-25	interleukin 6	Mus musculus	224-227
34828864-1	2021	This study shows the chemical-physical and nutritional results obtained using food-grade sea water for the preparation of fresh pasta Gnocchi with respect to those prepared with tap water.	Water	93-98	solute carrier family 45 member 1	Homo sapiens	128-133
34714059-6	2021	The harvested NF-PAA/PIP membrane showed an ~70% rise in water permeability (up to 23.5 L m-2 h-1 bar-1) while retaining high Na2SO4 and dye rejections.	Water	57-62	prolactin induced protein	Homo sapiens	14-24
34765796-3	2021	The brain acetylcholinesterase (AChE) as an indicator of neurotoxicity was significantly (P < 0.01) decreased after 10 days exposure of fish to heavy metal contained river water, while plasma glutamate oxalacetate transaminase and plasma glutamate pyruvate transaminase were significantly increased (P < 0.01).	Water	172-177	acetylcholinesterase	Oreochromis niloticus	32-36
34672575-5	2021	When voltage is applied, the ATR-SEIRA signal from encaged THF rapidly decreases, and the water characteristic O-H absorption peak exhibits an appreciable blue-shift.	Water	90-95	ATR serine/threonine kinase	Homo sapiens	29-32
34832056-9	2021	The flux rate and bovine serum albumin flux were also assessed, and the results showed an increase from 105 L/m2h to 114 L/m2h for water flux and the antifouling determined by bovine serum albumin flux increased from 23 L/m2h to 51 L/m2h.	Water	131-136	albumin	Homo sapiens	25-38
34586126-2	2021	Treatment of the PtII2PdII2 tetranuclear complex (Pd2{Pt(NH3)2(D-pen)2}2) ((1); D-H2pen = D-penicillamine) with CoX2 (X = Cl, Br) provided (PtII2PdII2CoII2)n coordination polymers (Co2(H2O)6(1))X4 ((2)X4), in which the PtII2PdII2 units of (1) are linked by (Co2(mu-H2O)(H2O)5)4+ moieties in a 3D network structure.	Water	185-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
34586126-2	2021	Treatment of the PtII2PdII2 tetranuclear complex (Pd2{Pt(NH3)2(D-pen)2}2) ((1); D-H2pen = D-penicillamine) with CoX2 (X = Cl, Br) provided (PtII2PdII2CoII2)n coordination polymers (Co2(H2O)6(1))X4 ((2)X4), in which the PtII2PdII2 units of (1) are linked by (Co2(mu-H2O)(H2O)5)4+ moieties in a 3D network structure.	Water	265-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
34586126-2	2021	Treatment of the PtII2PdII2 tetranuclear complex (Pd2{Pt(NH3)2(D-pen)2}2) ((1); D-H2pen = D-penicillamine) with CoX2 (X = Cl, Br) provided (PtII2PdII2CoII2)n coordination polymers (Co2(H2O)6(1))X4 ((2)X4), in which the PtII2PdII2 units of (1) are linked by (Co2(mu-H2O)(H2O)5)4+ moieties in a 3D network structure.	Water	270-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
34586126-3	2021	(2)X4 showed a colour change from orange to dark green upon dehydration, reflecting the geometrical conversion of the CoII centres in (Co2(mu-H2O)(H2O)5)4+ from an octahedron to a tetrahedron by the removal of aqua ligands.	Water	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
34586126-3	2021	(2)X4 showed a colour change from orange to dark green upon dehydration, reflecting the geometrical conversion of the CoII centres in (Co2(mu-H2O)(H2O)5)4+ from an octahedron to a tetrahedron by the removal of aqua ligands.	Water	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
34586126-4	2021	While both (2)Cl4 and (2)Br4 electrochemically catalysed water reduction to H2 in the solid state due to the presence of PdII active centres, water oxidation to O2 was catalysed only by (2)Br4, which is ascribed to the presence of Br- ions that mediate the catalytic reactions that occurred at CoII active centres.	Water	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
34586126-4	2021	While both (2)Cl4 and (2)Br4 electrochemically catalysed water reduction to H2 in the solid state due to the presence of PdII active centres, water oxidation to O2 was catalysed only by (2)Br4, which is ascribed to the presence of Br- ions that mediate the catalytic reactions that occurred at CoII active centres.	Water	142-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
34715525-7	2021	The bioinspired material exhibited an efficient water collection rate (WCR) of 14.9 +- 0.2 mg min-1 cm-2, which was 5.3 and 2.5 times larger than that on uniformed superhydrophilic and superhydrophobic surfaces, respectively.	Water	48-53	CD59 molecule (CD59 blood group)	Homo sapiens	94-104
34613323-0	2021	Water biocatalytic effect attenuates cytochrome P450-mediated carcinogenicity of diethylnitrosamine: A computational insight.	Water	0-5	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	37-52
34636556-4	2021	It is particularly noteworthy that SOD can effectively catalyze dismutation of the  O2- to produce H2O2 and O2, and Au@PANI with a good reduction and catalytic property can catalyze the produced H2O2 into H2O and O2.	Water	205-208	superoxide dismutase 1	Homo sapiens	35-38
34686053-0	2021	Influence of water models on water movement through AQP1.	Water	13-18	aquaporin 1 (Colton blood group)	Homo sapiens	52-56
34745183-7	2021	These include two water to water reactions mediated by Plastid terminal oxidase (PTOX) and Mehler and the ascorbate-glutathione (ASC-GSH) cycle, as a main non-enzymatic antioxidant.	Water	18-23	PYD and CARD domain containing	Homo sapiens	129-132
34745183-7	2021	These include two water to water reactions mediated by Plastid terminal oxidase (PTOX) and Mehler and the ascorbate-glutathione (ASC-GSH) cycle, as a main non-enzymatic antioxidant.	Water	27-32	PYD and CARD domain containing	Homo sapiens	129-132
34686053-0	2021	Influence of water models on water movement through AQP1.	Water	29-34	aquaporin 1 (Colton blood group)	Homo sapiens	52-56
34686053-6	2021	We present a numerical study of water diffusion through AQP1 comparing three water models: TIP3P, OPC, and TIP4P/2005.	Water	32-37	aquaporin 1 (Colton blood group)	Homo sapiens	56-60
34686053-6	2021	We present a numerical study of water diffusion through AQP1 comparing three water models: TIP3P, OPC, and TIP4P/2005.	Water	77-82	aquaporin 1 (Colton blood group)	Homo sapiens	56-60
34832695-8	2021	Furthermore, the limit of detection is around 0.70 ppb and 0.53 ppb for Hg(II) and Pb(II), respectively, which is lower than the maximum limits of 6 ppb and 10 ppb prescribed by the World Health Organization (WHO) for Hg(II) and Pb(II) in drinking water, respectively.	Water	248-253	submaxillary gland androgen regulated protein 3B	Homo sapiens	83-89
34670044-2	2021	Variants in AQP1, the gene that encodes the archetypal water channel aquaporin-1, may contribute to that variability.	Water	55-60	aquaporin 1 (Colton blood group)	Homo sapiens	12-16
34832695-8	2021	Furthermore, the limit of detection is around 0.70 ppb and 0.53 ppb for Hg(II) and Pb(II), respectively, which is lower than the maximum limits of 6 ppb and 10 ppb prescribed by the World Health Organization (WHO) for Hg(II) and Pb(II) in drinking water, respectively.	Water	248-253	submaxillary gland androgen regulated protein 3B	Homo sapiens	229-235
34636836-5	2021	The presence of water molecules around the encapsulated Pt6 cluster further enhances its stability, while the oxidation states of the encapsulated Ptn cluster are largely affected by the BAS site and the surrounding water molecules.	Water	216-221	pleiotrophin	Homo sapiens	147-150
34542146-3	2021	In the design of 4VPCB, one to three carbon atoms are inserted between the positive charge and negative charge (carbon space length, CSL) of the pyridyl-containing side chain to adjust hydration with water molecules.	Water	200-205	chorionic somatomammotropin hormone like 1	Homo sapiens	133-136
34146814-2	2021	These widespread communities in the intershrub spaces of drylands are able to use non-rainfall water inputs (NRWI) (fog, dewfall and water vapour) to become active and fix carbon dioxide (CO2), converting biocrusts into the main soil C contributors during periods in which vegetation remains inactive.	Water	95-100	zinc finger protein, FOG family member 1	Homo sapiens	116-119
34553710-0	2021	Facile water oxidation by dinuclear mixed-valence CoIII/CoII complexes: the role of coordinated water.	Water	7-12	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	50-55
34553710-0	2021	Facile water oxidation by dinuclear mixed-valence CoIII/CoII complexes: the role of coordinated water.	Water	96-101	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	50-55
34553710-3	2021	We have chosen dinuclear mixed-valence CoIIICoII complexes of the general formula of (CoIIICoII(LH2)2(X)(H2O)) (X = OAc or Cl) which bear a coordinated water molecule in the primary coordination sphere.	Water	105-108	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	39-48
34553710-3	2021	We have chosen dinuclear mixed-valence CoIIICoII complexes of the general formula of (CoIIICoII(LH2)2(X)(H2O)) (X = OAc or Cl) which bear a coordinated water molecule in the primary coordination sphere.	Water	105-108	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	86-95
34553710-3	2021	We have chosen dinuclear mixed-valence CoIIICoII complexes of the general formula of (CoIIICoII(LH2)2(X)(H2O)) (X = OAc or Cl) which bear a coordinated water molecule in the primary coordination sphere.	Water	152-157	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	39-48
34553710-3	2021	We have chosen dinuclear mixed-valence CoIIICoII complexes of the general formula of (CoIIICoII(LH2)2(X)(H2O)) (X = OAc or Cl) which bear a coordinated water molecule in the primary coordination sphere.	Water	152-157	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	86-95
34670899-1	2022	Serum tonicity is defined by the serum concentrations of sodium (sNa) and glucose, which can promote free water movement across intra/extracellular compartments.	Water	106-111	snail family transcriptional repressor 1	Homo sapiens	65-68
34685360-2	2021	A thermoresponsive polymer with upper critical solution temperature, poly(N-acryloyl glycinamide) (PNAGA), which is soluble in water at elevated temperatures but phase separates at low temperatures, has been shown to bind lysozyme, chosen as a model enzyme, at a low temperature (10  C and lower) but not at room temperature (around 25  C).	Water	127-132	lysozyme	Homo sapiens	222-230
34182389-3	2021	This study examined both the long-term trends in atmospheric nitrogen (N) deposition from the 1990s to the 2010s and the response of stream water nitrate (NO3-) leaching from forested areas in western Japan.	Water	140-145	NBL1, DAN family BMP antagonist	Homo sapiens	155-158
34664163-0	2022	Synthesis and application of graphene oxide as a nanoadsorbent to remove Cd (II) and Pb (II) from water: adsorption equilibrium, kinetics, and regeneration.	Water	98-103	submaxillary gland androgen regulated protein 3B	Homo sapiens	73-92
34622888-5	2021	Based on MD simulations, we propose that the magnitude of cation excess (which is salt specific) depends on the ability of the electrolyte to perturb the water network at the DNA interface: In the NaF atmosphere, the ions reduce the strength of interactions between water and the DNA more than in case of a NaCl electrolyte.	Water	154-159	C-X-C motif chemokine ligand 8	Homo sapiens	197-200
34622888-5	2021	Based on MD simulations, we propose that the magnitude of cation excess (which is salt specific) depends on the ability of the electrolyte to perturb the water network at the DNA interface: In the NaF atmosphere, the ions reduce the strength of interactions between water and the DNA more than in case of a NaCl electrolyte.	Water	266-271	C-X-C motif chemokine ligand 8	Homo sapiens	197-200
34635888-0	2021	Improving the surface hydrophobicity by the solvent effect to reduce the water erosion of the CL-20/TNT cocrystal explosive.	Water	73-78	epithelial membrane protein 1	Homo sapiens	94-99
34635888-4	2021	CL-20/TNT-water interfacial models were constructed, based on four important stable surfaces predicted using crystal morphology theory.	Water	10-15	epithelial membrane protein 1	Homo sapiens	0-5
34339711-2	2021	Consistent with the human data, NF1 heterozygous (Het) mice show impaired spatial learning and memory in the water maze and extinction of contextual fear memory.	Water	109-114	neurofibromin 1	Homo sapiens	32-35
34182389-9	2021	Concentrations of NO3- in the stream water samples from three of the four locations decreased significantly at an annual rate of -3.7 to -0.7% yr-1.	Water	37-42	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
34182389-10	2021	However, stream water NO3- concentrations increased in one watershed where understory vegetation has been deteriorating owing to the increased deer population.	Water	16-21	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
34684781-3	2021	XRD analysis showed a slight decrease in the interlayer space of halloysite in ionogels containing MCC, which may have been associated with the removal of residual water molecules resulting from hydrophilic IL anions and polymer macromolecules.	Water	164-169	MCC regulator of WNT signaling pathway	Homo sapiens	99-102
34591472-0	2021	DFT Study of Microsolvated (NO3 (H2O)n)- (n = 1-12) Clusters and Molecular Dynamics Simulation of Nitrate Solution.	Water	33-36	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
34591472-3	2021	In this work, we used a particle swarm optimization technique driven by density functional theory to sample the potential energy surface of various microsolvated (NO3 (H2O)n)- (n = 1-12) clusters.	Water	168-171	NBL1, DAN family BMP antagonist	Homo sapiens	163-166
34591472-5	2021	Moreover, by conducting ab initio molecular dynamics simulations, we showed that at low concentrations (~0.2 M) the NO3- species tend to be located on the surface of water solution.	Water	166-171	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
34591472-7	2021	As a result, from our calculations, we expect that at low concentration there could be oppositely signed concentration gradients for NO3- and K+ ions in a thin water film.	Water	160-165	NBL1, DAN family BMP antagonist	Homo sapiens	133-136
34523939-3	2021	Compared to native beta-CD, methylated beta cyclodextrins complexed with cholesterols demonstrated higher mechanical stabilities due to the loss of more high-energy water molecules inside the methylated beta-CD cavities.	Water	165-170	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	19-26
34523939-3	2021	Compared to native beta-CD, methylated beta cyclodextrins complexed with cholesterols demonstrated higher mechanical stabilities due to the loss of more high-energy water molecules inside the methylated beta-CD cavities.	Water	165-170	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	203-210
34590815-2	2021	Two main approaches to collect water from the atmosphere exist: the first is to capture it from fog, whereas the second is through condensation of vapor on surfaces with a temperature below the dew point.	Water	31-36	zinc finger protein, FOG family member 1	Homo sapiens	96-99
34633768-1	2022	Recent fragment-based drug design efforts have generated huge amounts of information on water and small molecule fragment binding sites on SARS-CoV-2 Mpro and preference of the sites for various types of chemical moieties.	Water	88-93	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	150-154
34712659-9	2021	In addition, knockdown of ATP2B1-AS1 decreased the latency time, increased the time of passing the platform position, reduced the cerebral infarct volume, decreased neurological deficit scores, and reduced the number of damaged neurons of MCAO/IR rats that were subjected to the Morris water maze test.	Water	286-291	ATPase plasma membrane Ca2+ transporting 1	Rattus norvegicus	26-32
34684730-3	2021	Catalase (CAT) can degrade hydrogen peroxide so that it produces less toxic water (H2O) and oxygen (O2) in order to reduce the harm caused by H2O2.	Water	76-81	catalase	Mus musculus	0-8
34684730-3	2021	Catalase (CAT) can degrade hydrogen peroxide so that it produces less toxic water (H2O) and oxygen (O2) in order to reduce the harm caused by H2O2.	Water	76-81	catalase	Mus musculus	10-13
34684730-3	2021	Catalase (CAT) can degrade hydrogen peroxide so that it produces less toxic water (H2O) and oxygen (O2) in order to reduce the harm caused by H2O2.	Water	83-86	catalase	Mus musculus	0-8
34684730-3	2021	Catalase (CAT) can degrade hydrogen peroxide so that it produces less toxic water (H2O) and oxygen (O2) in order to reduce the harm caused by H2O2.	Water	83-86	catalase	Mus musculus	10-13
34636042-1	2022	BACKGROUND: Based on the interrelationship among photosynthesis (Pn), water consumption and drought resistance physiology under water changes, this study aims to explore whether easily measured photosynthesis could be used to reflect the physiological state of winter wheat and soil moisture.	Water	128-133	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	65-67
34633768-4	2022	In this study, information on water and small molecule fragments bound to Mpro has been utilized to develop a novel Water Pharmacophore (Waterphore) model.	Water	30-35	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	74-78
34633768-4	2022	In this study, information on water and small molecule fragments bound to Mpro has been utilized to develop a novel Water Pharmacophore (Waterphore) model.	Water	116-121	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	74-78
34380286-10	2021	From the perspective of societal development scenarios, SSP1 provided better results for both the risk of food security and water security in the 21st century.	Water	124-129	SUMO specific peptidase 6	Homo sapiens	56-60
34087736-3	2021	First, we measured the chemical characteristics of water produced by a unique atmospheric water generator (AWG) apparatus in Tel Aviv, Israel.	Water	51-56	ETS variant transcription factor 6	Homo sapiens	125-128
34087736-3	2021	First, we measured the chemical characteristics of water produced by a unique atmospheric water generator (AWG) apparatus in Tel Aviv, Israel.	Water	90-95	ETS variant transcription factor 6	Homo sapiens	125-128
34380282-1	2021	Naturally occurring goethite commonly undergoes Al-substitution, while how changes in microstructure induced by Al-substitution affect the interactive reaction of Pb(II) or As(V) at the goethite-water interface remains poorly understood.	Water	195-200	submaxillary gland androgen regulated protein 3B	Homo sapiens	163-169
34380282-5	2021	CD-MUSIC modeling results further revealed that the affinity constant of Pb(II) complex (log KPb) at the goethite-water interface and the adsorption capacity of goethite for Pb(II) decreased with increasing amount of Al-substitution, while an opposite tendency was observed for As(V) adsorption.	Water	114-119	submaxillary gland androgen regulated protein 3B	Homo sapiens	73-79
34581118-9	2021	The NO3- concentration in the groundwater in this area exceeded the class III water standard but did not change the hydrochemical type classification.	Water	78-83	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
34623713-5	2021	Furthermore, the adsorption energy of water ( Delta E H 2 O    ) of Co sites in the CuCo-CAT is significantly lower than that of Cu sites upon coupling Cu with Co, effectively accelerating the Volmer step in the HER process.	Water	38-43	catalase	Homo sapiens	89-92
34581118-11	2021	The NO3-type water occurs in acidic or weakly acidic environments, typically characterized by low TDS and total hardness concentrations, and high Cl-, SO42-, and K+ concentrations.	Water	13-18	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
34581118-12	2021	The formation of NO3-type water is mainly affected by domestic sewage, industrial wastewater, agricultural nitrogen fertilizer, septic tank outflows, and landfill leachate leakage.	Water	26-31	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
34790737-3	2021	Results: The behavior data showed that overexpression of CysLT1R in hippocampal DG or administration of YM-17690 deteriorated behavioral performance in Morris water maze (MWM), Y-maze tests, and novel object recognition (NOR) in young APP/PS1 mice.	Water	159-164	cysteinyl leukotriene receptor 1	Mus musculus	57-64
34692569-3	2021	The loss of CFTR function alters chloride, bicarbonate, and water transport through the plasma membrane, promoting the production of a thick and sticky mucus in which bacteria including Pseudomonas aeruginosa and Burkholderia cenocepacia can produce chronic infections that eventually decrease the lung function and increase the risk of mortality.	Water	60-65	CF transmembrane conductance regulator	Homo sapiens	12-16
34691115-12	2021	Overall, these data provide new insights into the roles and modes of action of RabA2b during water stresses, and indicate that increased RabA2b mediated PM trafficking can affect the PM proteome and increase drought tolerance.	Water	93-98	RAB GTPase homolog A2B	Arabidopsis thaliana	79-85
34497177-6	2021	However, 2,6-di-O-methylated beta-CD (2,6-DMCD) formed a water-soluble inclusion complex with Toc, effectively enhancing its solubility.	Water	57-62	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	29-36
34549963-3	2021	We propose an in situ ATR-IR approach combining Gaussian fitting to qualitatively and quantitatively explore the temperature-dependent structural stability and transformation of the three water components, multimer water (MW), intermediate water (IW), and network water (NW), on interfaces with different wettabilities.	Water	188-193	ATR serine/threonine kinase	Homo sapiens	22-25
34601609-9	2021	RESULTS: Adipose expression of miR-130b and miR-17-5p correlated with parameters of muscle mass including intracellular water (miR-130b: r = 0.191, P = 0.02; miR-17-5p: r = 0.211, P = 0.013) and lean tissue mass (miR-130b: r = 0.180, P = 0.03; miR-17-5p: r = 0.176, P = 0.004).	Water	120-125	microRNA 130b	Homo sapiens	31-39
34601609-9	2021	RESULTS: Adipose expression of miR-130b and miR-17-5p correlated with parameters of muscle mass including intracellular water (miR-130b: r = 0.191, P = 0.02; miR-17-5p: r = 0.211, P = 0.013) and lean tissue mass (miR-130b: r = 0.180, P = 0.03; miR-17-5p: r = 0.176, P = 0.004).	Water	120-125	microRNA 130b	Homo sapiens	127-135
34549749-5	2021	Moreover, the shielding effectiveness of SPC can be enhanced from 10 dB to 30 dB with the assistance of water, ascribed to the super-wettability performance.	Water	104-109	surfactant protein C	Homo sapiens	41-44
34581383-0	2021	Biomimicking spider webs for effective fog water harvesting with electrospun polymer fibers.	Water	43-48	zinc finger protein, FOG family member 1	Homo sapiens	39-42
34581383-1	2021	Fog is an underestimated source of water, especially in regions where conventional methods of water harvesting are impossible, ineffective, or challenging for low-cost water resources.	Water	35-40	zinc finger protein, FOG family member 1	Homo sapiens	0-3
34581383-1	2021	Fog is an underestimated source of water, especially in regions where conventional methods of water harvesting are impossible, ineffective, or challenging for low-cost water resources.	Water	94-99	zinc finger protein, FOG family member 1	Homo sapiens	0-3
34581383-1	2021	Fog is an underestimated source of water, especially in regions where conventional methods of water harvesting are impossible, ineffective, or challenging for low-cost water resources.	Water	168-173	zinc finger protein, FOG family member 1	Homo sapiens	0-3
34581383-4	2021	We showed how fiber morphology and wetting properties can increase the fog collection rate, and also observed the influence of fog water collection parameters on testing their efficiency.	Water	131-136	zinc finger protein, FOG family member 1	Homo sapiens	127-130
34581383-6	2021	This is extremely important, as fog collection under laboratory conditions is the first step toward creating a new water harvesting technology.	Water	115-120	zinc finger protein, FOG family member 1	Homo sapiens	32-35
34690766-17	2021	In PI-IBS rats, the lack of PTRF not only reduced fecal water content and suppressed depressive behavior but also increased the body weight.	Water	56-61	caveolae associated protein 1	Rattus norvegicus	28-32
34639140-10	2021	This review discusses the most recent research investigations about the Abeta dynamics in water, close contact with cell membranes, and several therapeutic strategies to remove plaque formation.	Water	90-95	amyloid beta precursor protein	Homo sapiens	72-77
34641597-10	2021	The EDIdrink values for DMP, DEP, DIBP, DBP, BMEP, DAP, BEEP, BBP, DCP, DHP, BMPP, BBEP, DEHP, DOP, and DNP through the consumption of bottled mineral water (based on mean concentrations) were 0.45, 0.33, 12.5, 3.67, 2.10, 0.06, 0.32, 0.16, 0.10, 0.09, 0.05, 0.81, 112, 0.13, and 0.20 ng/kg-bw/d, respectively, for Chinese adults.	Water	151-156	dihydropyrimidinase	Homo sapiens	72-75
34473159-2	2021	On treatment with Cu(ClO4)2, HL1 yields a dinuclear mu-phenolatocopper(II) complex having the molecular formula (Cu2(L1)2)(ClO4)2(H2O)1.5 (1).	Water	130-133	asialoglycoprotein receptor 1	Homo sapiens	29-32
34477710-4	2021	Here we explore the roles of atmospheric water and carbon dioxide in mediating the transformation of the tetrahedrally coordinated potassium aluminate dimer salt (K2Al2O(OH)6) to gibbsite versus potassium dawsonite (KAl(CO3)(OH)2).	Water	41-46	anosmin 1	Homo sapiens	216-219
34671324-4	2021	In this study, we investigated the prevalence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolated from produce and irrigation water across 17 provinces of Ecuador.	Water	153-158	EsbL	Escherichia coli	49-81
34641564-1	2021	Here we present the synthesis, structure and magnetic properties of complexes of general formula (Mn)(Me2NH2)4)(Mn3(mu-L)6(H2O)6) and (Me2NH2)6(M3(mu-L)6(H2O)6) (M = CoII, NiII and CuII); L-2 = 4-(1,2,4-triazol-4-yl) ethanedisulfonate).	Water	154-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-170
34266892-1	2021	We used stable isotope-labeled glucose and palmitate tracer infusions, a hyperinsulinemic-euglycemic clamp, positron-emission tomography of muscles and adipose tissue after (18F)fluorodeoxyglucose and (15O)water injections, and subcutaneous adipose tissue (SAT) biopsy to test the hypotheses that: i) increased glucose uptake in SAT is responsible for high insulin-stimulated whole-body glucose uptake in people with obesity who are insulin-sensitive, and ii) putative SAT factors thought to cause insulin resistance are present in people with obesity who are insulin-resistant but not in those who are insulin-sensitive.	Water	206-211	insulin	Homo sapiens	357-364
34224008-2	2021	Renal unresponsiveness to the antidiuretic hormone vasopressin impairs aquaporin-2 (AQP2) water channel activity and water reabsorption from urine, resulting in polyuria.	Water	90-95	arginine vasopressin	Homo sapiens	51-62
34224008-2	2021	Renal unresponsiveness to the antidiuretic hormone vasopressin impairs aquaporin-2 (AQP2) water channel activity and water reabsorption from urine, resulting in polyuria.	Water	117-122	arginine vasopressin	Homo sapiens	51-62
34175740-10	2021	Taken together, novel ultrasmall mesoporous Ce-BGn showed remarkable catalase-mimic activity via surface containing Ce3+/Ce4+ ions which can scavenge ROS (Ce3+  Ce4+) and decompose H2O2 molecules into H2O and O2.	Water	201-204	biglycan	Homo sapiens	47-50
34763504-8	2021	RESULTS: After treatment, the serum levels of hypoxia inducible factor-1 (HIF-1alpha) and vascular endothelial growth factor (VEGF) in the observation group were significantly decreased and statistically lower than those in the control group (both P<0.05); the malignant pleural and abdominal water volume, average urine volume, and average chest circumference of the observation group were improved, and the difference was statistically significant compared with the control group (all P<0.05).	Water	293-298	vascular endothelial growth factor A	Homo sapiens	90-124
34763504-8	2021	RESULTS: After treatment, the serum levels of hypoxia inducible factor-1 (HIF-1alpha) and vascular endothelial growth factor (VEGF) in the observation group were significantly decreased and statistically lower than those in the control group (both P<0.05); the malignant pleural and abdominal water volume, average urine volume, and average chest circumference of the observation group were improved, and the difference was statistically significant compared with the control group (all P<0.05).	Water	293-298	vascular endothelial growth factor A	Homo sapiens	126-130
34185366-14	2021	Moreover, higher serum hs-CRP levels may be related to body fat and water alteration concomitant to a higher ED intake.	Water	68-73	C-reactive protein	Homo sapiens	26-29
34319541-1	2021	PURPOSE: Familial neurohypophysial diabetes insipidus (FNDI), commonly caused by autosomal dominant arginine vasopressin (AVP) mutations, is a rare condition in which vasopressin fails in regulating body"s level of water with final polyuria and polydipsia.	Water	215-220	arginine vasopressin	Homo sapiens	167-178
34224705-8	2021	The use of beta-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.	Water	118-123	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	11-18
34224705-8	2021	The use of beta-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.	Water	237-242	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	11-18
34224705-8	2021	The use of beta-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.	Water	313-318	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	11-18
34224705-11	2021	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and beta-CD/AuNPs was 0.005/min.	Water	74-79	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	119-126
34228952-9	2021	Moreover, the catalyst D-Pd1/Sn1 reached a complete nitrate removal in the municipal wastewater treatment plant effluent water within 3 h. The results provide a prospect for denitrification in biological wastewater treatment plants.	Water	121-126	transforming growth factor beta 1	Homo sapiens	23-28
34228952-9	2021	Moreover, the catalyst D-Pd1/Sn1 reached a complete nitrate removal in the municipal wastewater treatment plant effluent water within 3 h. The results provide a prospect for denitrification in biological wastewater treatment plants.	Water	121-126	solute carrier family 38 member 3	Homo sapiens	29-32
34363947-1	2021	Aquaporin-8 (AQP8) is a peroxiporin, a transmembrane water and hydrogen peroxide (H2O2) transport protein expressed in the mitochondrial and plasma membranes of pancreatic beta-cells.	Water	53-58	aquaporin 8	Rattus norvegicus	0-11
34363947-1	2021	Aquaporin-8 (AQP8) is a peroxiporin, a transmembrane water and hydrogen peroxide (H2O2) transport protein expressed in the mitochondrial and plasma membranes of pancreatic beta-cells.	Water	53-58	aquaporin 8	Rattus norvegicus	13-17
34087531-2	2021	The presented study describes these transformation processes around NO3- degradation at a water catchment in the Lower Rhine Embayment, Germany.	Water	90-95	NBL1, DAN family BMP antagonist	Homo sapiens	68-71
34266982-0	2021	Associations of Community Water Lead Concentrations with Hemoglobin Concentrations and Erythropoietin-Stimulating Agent Use among Patients with Advanced CKD.	Water	26-31	erythropoietin	Homo sapiens	87-101
34087531-11	2021	Substantial NO3- reduction in the vadose zone was observed: dependent on soil type, reduction capacity and water residence time, up to 25% of the NO3- was reduced here.	Water	107-112	NBL1, DAN family BMP antagonist	Homo sapiens	12-15
34087531-11	2021	Substantial NO3- reduction in the vadose zone was observed: dependent on soil type, reduction capacity and water residence time, up to 25% of the NO3- was reduced here.	Water	107-112	NBL1, DAN family BMP antagonist	Homo sapiens	146-149
34524834-6	2021	The thermal denaturation free energy change DeltaDeltaG value calculated for the long-lived structure at higher temperatures of 348 and 363 K ranges from 2.58 to 2.78 kcal/mol for the SPC/E water model, which agrees well with the experimentally reported thermal denaturation free energy range of 2.874 kcal/mol of SARS CoV-NP at normal pH.	Water	190-195	surfactant protein C	Homo sapiens	184-187
34252873-4	2021	We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T2 relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter.	Water	36-41	renin binding protein	Homo sapiens	17-20
34252873-4	2021	We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T2 relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter.	Water	36-41	renin binding protein	Homo sapiens	222-225
34252873-4	2021	We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T2 relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter.	Water	259-264	renin binding protein	Homo sapiens	17-20
34252873-4	2021	We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T2 relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter.	Water	259-264	renin binding protein	Homo sapiens	222-225
34252873-4	2021	We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T2 relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter.	Water	393-398	renin binding protein	Homo sapiens	17-20
34849123-13	2021	The predominance of TIMP-1 over MMP-1 in blood serum can potentially limit TEWL and maintain the proper water content of the epidermis.	Water	104-109	TIMP metallopeptidase inhibitor 1	Homo sapiens	20-26
34102274-7	2021	In conclusion, PGE2 injection resulted in decreased food and water intake that likely involves BDNF and ghrelin originating in the PVN.	Water	61-66	brain derived neurotrophic factor	Gallus gallus	95-99
34588880-7	2021	It was observed that the level of cytokines pro-inflammatory (IL-17, IL-6, IL-2, IL-4, INF-gamma) in serum was normalized in mice treated with ICE, which would indicate that polyP prevents the local inflammatory response in the respiratory tract.	Water	143-146	interleukin 6	Mus musculus	69-73
34107028-0	2021	APS reductase and sulfite oxidase regulate sulfite-induced water loss in Arabidopsis.	Water	59-64	sulfite oxidase	Arabidopsis thaliana	18-33
34665768-8	2021	It can be concluded that the traditional CPF is a viable option for water supply treatment at the household level for the removal of chemical contaminants.	Water	68-73	nuclear receptor subfamily 5 group A member 2	Homo sapiens	41-44
34215136-0	2021	MWCNTs-CoP hybrids for dual-signal electrochemical immunosensing of carcinoembryonic antigen based on overall water splitting.	Water	110-115	CEA cell adhesion molecule 3	Homo sapiens	68-92
34514483-5	2021	We show that Zn2+ coordinates with the catalytic dyad at the enzyme active site along with two previously unknown water molecules in a tetrahedral geometry to form a stable inhibited Mpro-Zn2+ complex.	Water	114-119	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	183-187
34524834-7	2021	At higher temperatures, the stability of RNA conformation is found to be due to the existence of non-native base pairs in the SPC/E water model.	Water	132-137	surfactant protein C	Homo sapiens	126-129
34810776-5	2021	Some characters of taxa from the lilljeborgi-group are convergently similar to the characters of the species of genus Graptoleberis Sars, 1862; both groups are adapted to a snail-like crawling on the surface of water macrophytes.	Water	211-216	snail family transcriptional repressor 1	Homo sapiens	173-178
34659087-10	2021	It is suggested that long-lasting high levels of plasma vasopressin could have adverse effects on inner ear water metabolism and the subsequent Meniere"s disease symptoms.	Water	108-113	arginine vasopressin	Homo sapiens	56-67
34585668-4	2021	Vasopressin (AVP) is a key hormone regulating water balance and is released during hyperosmolality to limit renal water excretion.	Water	46-51	arginine vasopressin	Homo sapiens	0-11
34415632-1	2021	Water is the most sustainable source for H2 production, and the efficient electrocatalytic production of H2 from mixed water/acetonitrile solutions by using two new air-stable nickel(II) pincer complexes, (Ni(kappa3 -2,6-{Ph2 PNR}2 (NC5 H3 )Br2 ) (R=H I, Me II) is reported.	Water	0-5	trefoil factor 1	Homo sapiens	226-231
34515779-4	2021	It has been shown that sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA, protects against cigarette smoke (CS)-induced emphysema/COPD in mice.	Water	64-69	ATPase, class II, type 9A	Mus musculus	41-44
34598583-5	2021	We show how our CG model qualitatively captures the experimental radius of the gyration trend of a subset of intrinsically disordered proteins and reproduces the experimental protein concentration and water percentage of the human fused in sarcoma (FUS) low-complexity-domain droplets at physiological salt concentration.	Water	201-206	FUS RNA binding protein	Homo sapiens	231-247
34598583-5	2021	We show how our CG model qualitatively captures the experimental radius of the gyration trend of a subset of intrinsically disordered proteins and reproduces the experimental protein concentration and water percentage of the human fused in sarcoma (FUS) low-complexity-domain droplets at physiological salt concentration.	Water	201-206	FUS RNA binding protein	Homo sapiens	249-252
34415632-1	2021	Water is the most sustainable source for H2 production, and the efficient electrocatalytic production of H2 from mixed water/acetonitrile solutions by using two new air-stable nickel(II) pincer complexes, (Ni(kappa3 -2,6-{Ph2 PNR}2 (NC5 H3 )Br2 ) (R=H I, Me II) is reported.	Water	119-124	trefoil factor 1	Homo sapiens	226-231
34632041-6	2021	On the other hand, the average concentration of E. coli in the water samples was 2.0 x 108 CFU/100 mL, and the ratio of ESBL-producing E. coli was 12.8% of total E. coli.	Water	63-68	EsbL	Escherichia coli	120-124
34603816-9	2021	The results of the present study suggest that new adsorbents can be effectively utilized for As(III), Pb(II), and Zn(II) removal from water.	Water	134-139	submaxillary gland androgen regulated protein 3B	Homo sapiens	102-108
34491745-2	2021	beta-Cyclodextrin (beta-CD) is a water-dispersible molecule with a hydrophobic core that can encapsulate and protect non-polar substances.	Water	33-38	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	19-26
34680401-5	2021	In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology.	Water	23-28	amyloid beta precursor protein	Homo sapiens	77-89
34685367-1	2021	We combined broad-band depolarized light scattering and infrared spectroscopies to study the properties of hydration water in a lysozyme-trehalose aqueous solution, where trehalose is present above the concentration threshold (30% in weight) relevant for biopreservation.	Water	117-122	lysozyme	Homo sapiens	128-136
34584907-3	2021	Our results showed that 1 h exposure to water avoidance stress (WAS) for 7 consecutive days decreased histone acetylation at the GR promoter and increased histone acetylation at the CRH promoter in the CeA.	Water	40-45	corticotropin releasing hormone	Rattus norvegicus	182-185
34546425-6	2021	Upon arrival, arginines on HD5 interact with lipid A head groups (a top part of LPS) and then drag these charged moieties down into a hydrophobic core resulting in the formation of water-filled pore.	Water	181-186	defensin alpha 5	Homo sapiens	27-30
34575135-5	2021	In addition, ET-1 is involved in the complex regulation of BP through synergistic interactions with angiotensin II, regulates the production of catecholamines and sympathetic activity, affects renal hemodynamics and water-salt balance, and regulates baroreceptor activity and myocardial contractility.	Water	216-221	endothelin 1	Homo sapiens	13-17
34575135-5	2021	In addition, ET-1 is involved in the complex regulation of BP through synergistic interactions with angiotensin II, regulates the production of catecholamines and sympathetic activity, affects renal hemodynamics and water-salt balance, and regulates baroreceptor activity and myocardial contractility.	Water	216-221	angiotensinogen	Homo sapiens	100-114
34574332-7	2021	The water-only washed SPC showed the highest viscosity, and formed gels with the highest gel strength and hardness among all the SPCs at a similar protein concentration.	Water	4-9	surfactant protein C	Homo sapiens	22-25
34090073-5	2021	Two types of reclaimed water, i.e., secondary effluent and MBR (membrane bioreactor) effluent, were found to induce pulmonary injury and inflammation in the wild-type mice and Tlr4-/- mutants.	Water	23-28	toll-like receptor 4	Mus musculus	176-180
34090073-7	2021	In summary, non-TLR4 signalling pathways are related to lung inflammation caused by long-term exposure to reclaimed water.	Water	116-121	toll-like receptor 4	Mus musculus	16-20
34578073-3	2021	Additionally, the capacity of cellulose derivatives to adsorb Pb(II) ions in an aqueous solution was studied through the determination of Pb(II) ions concentration in water, using microwave plasma atomic emission spectroscopy (MP-AES).	Water	167-172	submaxillary gland androgen regulated protein 3B	Homo sapiens	62-68
34578073-3	2021	Additionally, the capacity of cellulose derivatives to adsorb Pb(II) ions in an aqueous solution was studied through the determination of Pb(II) ions concentration in water, using microwave plasma atomic emission spectroscopy (MP-AES).	Water	167-172	submaxillary gland androgen regulated protein 3B	Homo sapiens	138-144
34531392-1	2021	To address the global water shortage crisis, one of the promising solutions is to collect freshwater from the environmental resources such as fog.	Water	22-27	zinc finger protein, FOG family member 1	Homo sapiens	142-145
34938576-1	2021	Fog harvesting through bionic strategies to solve water shortage has drawn considerable attention.	Water	50-55	zinc finger protein, FOG family member 1	Homo sapiens	0-3
34102366-3	2021	Moreover, SAFe-OCN showed excellent performance for contaminant degradation in complex water matrices and high stability in oxidation.	Water	87-92	bone gamma-carboxyglutamate protein	Homo sapiens	15-18
34574656-7	2021	Subjects" drinking water arsenic concentrations were positively associated with total urinary arsenic concentrations and the percentages of MMA, as well as inversely associated with the percentages of DMA and the secondary methylation index (SMI).	Water	19-24	monocyte to macrophage differentiation associated	Homo sapiens	140-143
34516009-2	2022	Association with human serum albumin (HSA), a water-soluble protein, causes dissociation of the self-aggregation, resulting in recovery of the photosensitizer activity of EGP(V)TBPP.	Water	46-51	albumin	Homo sapiens	23-36
34938576-8	2021	This easy manufacturing and low-cost fog collector may represent a useful tool for harvesting fog water for production and living and pave the way for further investigations.	Water	98-103	zinc finger protein, FOG family member 1	Homo sapiens	37-40
34938576-8	2021	This easy manufacturing and low-cost fog collector may represent a useful tool for harvesting fog water for production and living and pave the way for further investigations.	Water	98-103	zinc finger protein, FOG family member 1	Homo sapiens	94-97
34557519-3	2021	In this study, we focus on the Disp from water bear, a primitive animal known as the most indestructible on Earth.	Water	41-46	dispatched	Drosophila melanogaster	31-35
34537801-10	2021	Contrast water therapy resulted in significantly higher (g = 0.56) interleukin-6 concentrations vs. HWI.	Water	9-14	interleukin 6	Bos taurus	67-80
34574240-2	2021	The study aimed to examine how cooking pasta (1) in salted water (1 teaspoon-16 g of salt per 1 litre of water) or unsalted water and (2) rinsing cooked pasta with running water affects the content of minerals.	Water	59-64	solute carrier family 45 member 1	Homo sapiens	39-44
34574240-2	2021	The study aimed to examine how cooking pasta (1) in salted water (1 teaspoon-16 g of salt per 1 litre of water) or unsalted water and (2) rinsing cooked pasta with running water affects the content of minerals.	Water	105-110	solute carrier family 45 member 1	Homo sapiens	39-44
34574240-2	2021	The study aimed to examine how cooking pasta (1) in salted water (1 teaspoon-16 g of salt per 1 litre of water) or unsalted water and (2) rinsing cooked pasta with running water affects the content of minerals.	Water	172-177	solute carrier family 45 member 1	Homo sapiens	39-44
34574240-2	2021	The study aimed to examine how cooking pasta (1) in salted water (1 teaspoon-16 g of salt per 1 litre of water) or unsalted water and (2) rinsing cooked pasta with running water affects the content of minerals.	Water	172-177	solute carrier family 45 member 1	Homo sapiens	153-158
34574240-13	2021	The best method of culinary treatment of pasta is cooking in unsalted water without rinsing.	Water	70-75	solute carrier family 45 member 1	Homo sapiens	41-46
34575829-0	2021	Multi-Systemic Alterations by Chronic Exposure to a Low Dose of Bisphenol A in Drinking Water: Effects on Inflammation and NAD+-Dependent Deacetylase Sirtuin1 in Lactating and Weaned Rats.	Water	88-93	sirtuin 1	Rattus norvegicus	123-158
34557519-4	2021	Using a zebrafish model, we show that the water bear homolog possesses the function of Disp.	Water	42-47	dispatched	Drosophila melanogaster	87-91
34557519-6	2021	Consistent with the evolutional conservation of the pathway, the water bear Disp structure is overall similar to the previously reported structures of the fruit fly and human homologs.	Water	65-70	dispatched	Drosophila melanogaster	76-80
34557519-7	2021	Although not revealing much detail at this resolution, the water bear Disp shows a different conformation compared to published structures, suggesting that they represent different functional snapshots.	Water	59-64	dispatched	Drosophila melanogaster	70-74
34527169-8	2021	The pathways related to these genes were the estrogen signaling pathway, vasopressin-regulated water reabsorption, thyroid hormone synthesis, aldosterone synthesis and secretion, insulin secretion, circadian entrainment, insulin resistance, cholinergic synapse, dopaminergic synapse, cGMP-PKG signaling pathway, cAMP signaling pathway, PI3K-Akt signaling pathway, TNF signaling pathway, and AMPK signaling pathway.	Water	95-100	arginine vasopressin	Rattus norvegicus	73-84
34416109-4	2021	We report here a bioinspired NiII complex built on an ATCUN-like binding motif modulated with one cysteine, which demonstrates catalytic SOD activity in water (kcat = 8.4(2) x 105 M-1 s-1 at pH = 8.1).	Water	153-158	superoxide dismutase 1	Homo sapiens	137-140
34406771-1	2021	We calculate the rate of dissociation of an insulin dimer into two monomers in water.	Water	79-84	insulin	Homo sapiens	44-51
34216844-1	2021	This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified beta-cyclodextrin (Ag-beta-CD) composite.	Water	92-97	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	155-162
34229395-6	2021	The reusability of G-nZVI-BC and the PNP removal effect in water body conditions indicated that G-nZVI-BC had a good application prospect in the field of water treatment.	Water	59-64	purine nucleoside phosphorylase	Homo sapiens	37-40
34229395-6	2021	The reusability of G-nZVI-BC and the PNP removal effect in water body conditions indicated that G-nZVI-BC had a good application prospect in the field of water treatment.	Water	154-159	purine nucleoside phosphorylase	Homo sapiens	37-40
34475406-1	2021	Peroxisome, a special cytoplasmic organelle, possesses one or more kinds of oxidases for hydrogen peroxide (H2O2) production and catalase for H2O2 degradation, which serves as an intracellular H2O2 regulator to degrade toxic peroxides to water.	Water	238-243	catalase	Homo sapiens	129-137
34167403-6	2021	RESULTS: Treatment with coconut water significantly (P < 0.05) increased red blood cell, packed cell volume, haemoglobin, high density lipoprotein, glutathione, superoxide dismutase, catalase, total protein, and albumin compared to the negative control in both sexes of the rats.	Water	32-37	catalase	Rattus norvegicus	183-191
34265335-4	2021	Here, it is shown that insertion of small amounts of 4-(2-hydroxyethyl)-1-piperazineethanesulfonate (HEPES, 0.1 M) as a second additive to lysozyme-NaCl-water solutions near physiological ionic strength (0.2 M) is an essential step for triggering conversion of protein-rich droplets into another phase.	Water	153-158	lysozyme	Homo sapiens	139-147
34182310-13	2021	The current compounds (H2L, VOL, ZrOL and ZnL(H2O)2) and STI were found to bind with C-kit of TKR with HBs at ILE789.A, ILE808.A, ASP810.A, GLU640.A and TYR846 amino acid residue and the binding energies were - 8.9, -8.93, -8.83, -1.48 and -10.39 kcal/mol respectively.	Water	46-49	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	85-90
34334113-3	2021	Silencing ZEB2 alleviated ICH-induced neurologic deficits and the increase of BBB permeability, brain water content and ZEB2 expression.	Water	102-107	zinc finger E-box binding homeobox 2	Rattus norvegicus	10-14
34265181-7	2021	The excellent method recoveries were in the range of 90.0-98.4%, 92.0-98.2%, and 92.0-98.0% for river water, lake water, and tap water sample, respectively.	Water	129-134	SEC14 like lipid binding 2	Homo sapiens	125-128
34409609-3	2021	Herein, a high-efficiency and eco-friendly preparation method of an inclusion (allicin@alpha-CD) formed by allicin and alpha-CD was designed, which turned liquid allicin into crystal particles with high-speed stirring (10,000 r/min) at 25 C for 10 min in water.	Water	255-260	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	87-95
34409609-3	2021	Herein, a high-efficiency and eco-friendly preparation method of an inclusion (allicin@alpha-CD) formed by allicin and alpha-CD was designed, which turned liquid allicin into crystal particles with high-speed stirring (10,000 r/min) at 25 C for 10 min in water.	Water	255-260	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	119-127
34175710-0	2021	PM2.5 and water-soluble components induce airway fibrosis through TGF-beta1/Smad3 signaling pathway in asthmatic rats.	Water	10-15	transforming growth factor, beta 1	Rattus norvegicus	66-75
34146651-2	2021	METHODS: We developed a new multi-inversion-recovery (mIR) water mapping-MRF based on an unbalanced steady-state coherent sequence (FISP).	Water	59-64	microRNA 615	Mus musculus	54-57
34146651-4	2021	Data from our proposed mIR MRF was used to quantify different compartments, including myelin water, gray matter free water, and white matter free water, of brain water by virtue of the iterative non-negative least square (NNLS) with reweighting.	Water	93-98	microRNA 615	Mus musculus	23-26
34146651-4	2021	Data from our proposed mIR MRF was used to quantify different compartments, including myelin water, gray matter free water, and white matter free water, of brain water by virtue of the iterative non-negative least square (NNLS) with reweighting.	Water	117-122	microRNA 615	Mus musculus	23-26
34175710-0	2021	PM2.5 and water-soluble components induce airway fibrosis through TGF-beta1/Smad3 signaling pathway in asthmatic rats.	Water	10-15	SMAD family member 3	Rattus norvegicus	76-81
34146651-4	2021	Data from our proposed mIR MRF was used to quantify different compartments, including myelin water, gray matter free water, and white matter free water, of brain water by virtue of the iterative non-negative least square (NNLS) with reweighting.	Water	146-151	microRNA 615	Mus musculus	23-26
34146651-4	2021	Data from our proposed mIR MRF was used to quantify different compartments, including myelin water, gray matter free water, and white matter free water, of brain water by virtue of the iterative non-negative least square (NNLS) with reweighting.	Water	162-167	microRNA 615	Mus musculus	23-26
34175710-6	2021	Meanwhile, PM2.5, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1).	Water	32-37	interleukin 6	Rattus norvegicus	140-153
34146651-8	2021	As compared to the conventional MRF technique with single IR, our proposed mIR improved the detection of myelin water content.	Water	112-117	microRNA 615	Mus musculus	75-78
34146651-11	2021	Meanwhile, 5 IR MRF showed fewer artifacts in myelin water detection.	Water	53-58	microRNA 615	Mus musculus	13-15
34175710-6	2021	Meanwhile, PM2.5, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1).	Water	32-37	interleukin 6	Rattus norvegicus	155-159
34175710-6	2021	Meanwhile, PM2.5, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1).	Water	32-37	transforming growth factor, beta 1	Rattus norvegicus	162-194
34175710-6	2021	Meanwhile, PM2.5, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1).	Water	32-37	transforming growth factor, beta 1	Rattus norvegicus	196-205
34175710-6	2021	Meanwhile, PM2.5, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1).	Water	32-37	SMAD family member 3	Rattus norvegicus	208-228
34175710-6	2021	Meanwhile, PM2.5, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1).	Water	32-37	SMAD family member 3	Rattus norvegicus	230-235
34175710-6	2021	Meanwhile, PM2.5, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1).	Water	32-37	SMAD family member 3	Rattus norvegicus	244-249
34175710-7	2021	However, pretreating asthmatic rats with SB432542, the inhibitor of TGF-beta1, and SIS3 HCl, the antagonist of Smad3, both reversed the activation of airway fibrosis induced by water-soluble extracts.	Water	177-182	transforming growth factor, beta 1	Rattus norvegicus	68-77
34175710-7	2021	However, pretreating asthmatic rats with SB432542, the inhibitor of TGF-beta1, and SIS3 HCl, the antagonist of Smad3, both reversed the activation of airway fibrosis induced by water-soluble extracts.	Water	177-182	SMAD family member 3	Rattus norvegicus	111-116
34175710-8	2021	Therefore, TGF-beta1/Smad3 signaling pathway may be responsible for the pathological process of airway fibrosis in asthmatic rats following PM2.5 and water-soluble components exposure.	Water	150-155	transforming growth factor, beta 1	Rattus norvegicus	11-20
34175710-8	2021	Therefore, TGF-beta1/Smad3 signaling pathway may be responsible for the pathological process of airway fibrosis in asthmatic rats following PM2.5 and water-soluble components exposure.	Water	150-155	SMAD family member 3	Rattus norvegicus	21-26
34483144-7	2021	The anti-inflammatory effect of betaine was confirmed by the downregulation of pro-inflammation-related molecules, including vascular cell adhesion molecule 1 and interleukin-1beta in the retinas of rats with EAU.	Water	209-212	interleukin 1 beta	Rattus norvegicus	163-180
34246991-8	2021	However, in real water samples, the selectivity and efficiency for HEDP removal in the Co(II)/PMS process are higher than that in free radicals-mediated advanced oxidation processes.	Water	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
34468866-3	2021	Here, we have studied the interaction between 2-hydroxypropyl beta-CD (HPbetaCD) and three water-soluble drugs, namely naloxone (NX), oxycodone (OC), and tramadol (TR), by isothermal titration calorimetry (ITC) combined with molecular modeling in view of the potential impact on drug release.	Water	91-96	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	62-69
34214612-4	2021	MATERIALS AND METHODS: In a bottom-up approach starting from the chemical track evolution of 1 MeV electrons in oxygenated water simulated with the TRAX-CHEM Monte Carlo code, we determine the oxygen consumption and radiolytic reactive oxygen species production following a short radiation pulse.	Water	123-128	translin associated factor X	Homo sapiens	148-152
34380313-2	2021	We recently reported a Co(III)-N2O2 complex with a 2,2"-bipyridine-based ligand backbone which showed alternative selectivity: H2O was observed as the primary reduction product from O2 (71 +- 5%) with decamethylferrocene as a chemical reductant and acetic acid as a proton donor in methanol solution.	Water	127-130	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	23-30
34532317-8	2021	The IL-6-mediated enhanced osmotic sensitivity of RA-FLS likely involves NKCC1 and aquaporin-1, which mainly constitute the volume-associated ion transporter and water channel elements.	Water	162-167	interleukin 6	Homo sapiens	4-8
34455763-4	2021	Results: Ctnnd2-KO mice were with typical autism-like behaviors as evidenced by reduced social interaction in three-chamber sociability test, more frequent stereotypic behaviors (self-grooming), and deficits in spatial learning and memory tested by the Morris water maze.	Water	260-265	catenin (cadherin associated protein), delta 2	Mus musculus	9-15
34341816-2	2021	In our work, a ball-flower-like NiS/Zn3In2S6/g-C3N4 photocatalyst fabricated by a hydrothermal method exhibited superior performance for photocatalytic water splitting.	Water	152-157	solute carrier family 5 member 5	Homo sapiens	32-35
34448973-13	2021	Interleukin (IL) 1beta, IL-6, IL-8, and TNFalpha were also increased in the T1DM mice with water deprivation.	Water	91-96	interleukin 6	Mus musculus	24-28
34448973-13	2021	Interleukin (IL) 1beta, IL-6, IL-8, and TNFalpha were also increased in the T1DM mice with water deprivation.	Water	91-96	tumor necrosis factor	Mus musculus	40-48
34532317-8	2021	The IL-6-mediated enhanced osmotic sensitivity of RA-FLS likely involves NKCC1 and aquaporin-1, which mainly constitute the volume-associated ion transporter and water channel elements.	Water	162-167	aquaporin 1 (Colton blood group)	Homo sapiens	83-94
34532317-9	2021	These results suggest that RA-FLS provide enhanced electrolytes and concomitant water movement through NKCC1 and aquaporin-1, thereby inducing cellular swelling ultimately resulting in cytotoxic edema.	Water	80-85	aquaporin 1 (Colton blood group)	Homo sapiens	113-124
34577578-9	2021	In addition, it is possible that increased expression of AQP3, which plays an important role in skin water retention, is a contributor to the mechanism.	Water	101-106	aquaporin 3	Mus musculus	57-61
34428264-3	2021	Out of 40 water samples, characteristic growth (E. coli and the KESC group) on Chromagar ESBL plates was observed for 33 samples.	Water	10-15	EsbL	Escherichia coli	89-93
34578494-7	2021	The investigation of the fibrous layers produced determined that following contact with water the polyvinyl alcohol dissolved leading to the release of the albumin accompanied by the swelling of the alginate and the formation of a hydrogel.	Water	88-93	albumin	Homo sapiens	156-163
34405223-4	2021	The water balance mainly depends on the regulation of aquaporin-2 (AQP2) by arginine vasopressin (AVP) in renal collecting duct principal cells.	Water	4-9	arginine vasopressin	Homo sapiens	85-96
34428264-10	2021	We confirmed the presence of highly diverse ESBL strains with multiple drug resistance patterns in the Tricity water reservoirs.	Water	111-116	EsbL	Escherichia coli	44-48
34417312-3	2021	We demonstrate this 2D-EVSFG technique by investigating photoexcited interface-active (E)-4-((4-(dihexylamino) phenyl)diazinyl)-1-methylpyridin-1- lum (AP3) molecules at the air-water interface as an example.	Water	178-183	lumican	Homo sapiens	147-150
34420198-13	2022	In conclusion, our observations suggested that water and electrolyte imbalance in adipsic hypernatremia is characterized by a certain amount of vasopressin release regardless of serum sodium concentrations with no response to hyperosmolarity.	Water	47-52	arginine vasopressin	Homo sapiens	144-155
34452273-8	2021	Lipophilicity of insulin in terms of log Poctanol/water was improved from -1.8 to 2.1.	Water	50-55	insulin	Homo sapiens	17-24
34269774-1	2021	Herein we report heteroleptic Co(ii) diimine complexes (Co(H2bip)2Cl2) (1), (Co(H2bip)2Br2) (2), (Co(H2bip)3)Br2 1MeOH (3) and (Co(H2bip)2(Me2bpy))Br2 (MeCN)0.5 (H2O)0.25 (4) (H2bip = 2,2"-bi-1,4,5,6-tetrahydropyrimidine, bpy = 2,2"-dipyridyl, Me2bpy = 4,4"-Me-2,2"-dipyridyl), purposefully prepared to enable a systematic study of magnetic property changes arising from the increase of overall ligand field from sigma/pi-donor chlorido (1) to pi-acceptor 4,4"Me-2,2"bpy (4).	Water	162-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
34337627-1	2021	Introduction of the propyl-sulfonic acid group at N1 of the coordinated 2-(2-pyridyl)benzimidazole ligand (L) in (RhCl(eta5-C5Me5)L)(CF3SO3) gives rise to a water-soluble complex, which can bind to the model protein lysozyme via non-covalent interactions.	Water	157-162	lysozyme	Homo sapiens	216-224
34342968-1	2021	It has recently been demonstrated that harps harvest substantively more fog water than conventional mesh nets, but the optimal design for fog harps remains unknown.	Water	76-81	zinc finger protein, FOG family member 1	Homo sapiens	72-75
34820582-6	2022	PLGA/nHA30 VEGF had an average pore size of 227.6 mum and a water contact angle of 56.5  with a sustained release profile of vascular endothelial growth factor (VEGF).	Water	60-65	vascular endothelial growth factor A	Homo sapiens	11-15
34418454-6	2022	Additionally, both water-soluble rhodamine B- and liposoluble coumarin 6-labeled MLNs were found to penetrate deeply into the skin through the hair follicles and could be internalized by fibroblasts (CCC-ESF-1).	Water	19-24	ESF1 nucleolar pre-rRNA processing protein homolog	Homo sapiens	204-209
34451009-5	2021	TNT was dissolved in water as well as in hexane.	Water	21-26	chromosome 16 open reading frame 82	Homo sapiens	0-3
34355571-3	2021	We found the oxygen evolution reaction is controlled by the formation of empty Ir 5d states in the surface ascribed to the formation of formally IrV species leading to the appearance of electron-deficient oxygen species bound to single iridium atoms (mu1-O and mu1-OH) that are responsible for water activation and oxidation.	Water	294-299	glutathione S-transferase mu 1	Homo sapiens	251-254
34355571-3	2021	We found the oxygen evolution reaction is controlled by the formation of empty Ir 5d states in the surface ascribed to the formation of formally IrV species leading to the appearance of electron-deficient oxygen species bound to single iridium atoms (mu1-O and mu1-OH) that are responsible for water activation and oxidation.	Water	294-299	glutathione S-transferase mu 1	Homo sapiens	261-264
34408222-1	2021	Nitrate (NO3-) pollution is a serious global problem, and the quantitative analysis of its sources contributions is essential for devising effective water-related environmental-protection policies.	Water	149-154	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
34408222-5	2021	The NO3- in surface water from the mid-upper reaches of the drainage basin mainly originates from soil nitrogen (SN) and chemical fertilizer (CF), with contribution rates of 48% and 32%, respectively, and the NO3- in downstream areas mainly originates from CF and manure and sewage (MS), with contribution rates of 48% and 33%, respectively.	Water	20-25	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
34342421-1	2021	A class of water-soluble electrochemiluminescence (ECL) nanodots were prepared by encapsulating ECL-active iridium complexes into biocompatible horse spleen apoferritin (apoHSF) nanocages for immunoassays.	Water	11-16	ferritin heavy chain	Equus caballus	157-168
34584766-1	2021	The asymmetric unit of the polymeric title compound {(Co2(C12H7NO8)(H2O)2) 1.6H2O} n comprises two CoII ions, which are coordinated by fully deprotonated 2-aminodi-acetic terephthalic acid (adtp4-) and terminal water mol-ecules in distorted octa-hedral N1O5 and O6 coordination environments.	Water	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
34584766-1	2021	The asymmetric unit of the polymeric title compound {(Co2(C12H7NO8)(H2O)2) 1.6H2O} n comprises two CoII ions, which are coordinated by fully deprotonated 2-aminodi-acetic terephthalic acid (adtp4-) and terminal water mol-ecules in distorted octa-hedral N1O5 and O6 coordination environments.	Water	211-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
34328001-3	2021	Herein, inspired by a recent unveiled structure of Zn6(H2O)3(BTP)4 and by means of an amide-functionalized preliminary single tricarboxylate, a subsequent mixed tricarboxylate, and dicarboxylate linkers, an intricate three-way rod MOF and the next three isoreticular three-way rod MOFs have been successfully realized, namely, 3W-ROD-1 and 3W-ROD-2-X (X = -OH, -F, and -CH3), respectively.	Water	55-58	polypyrimidine tract binding protein 3	Homo sapiens	330-342
34225168-3	2021	The model system of hCA VII included the core catalytic center, the Zn2+ ion, its three histidine ligands and a hydroxide ion or water molecule coordinated to it.	Water	129-134	carbonic anhydrase 7	Homo sapiens	20-27
34492822-3	2021	Carboxylated polypropylene (PP-g-AA) fibers-ball with high selectivity as adsorbent was used in the Cd(II) contaminated soil-water system.	Water	125-130	serglycin	Homo sapiens	28-32
34492822-5	2021	Moreover, Cd(II) desorbed from soil to water could be continuously adsorbed by PP-g-AA fibers-ball, which kept the Cd2+ concentration always at a low level.	Water	39-44	serglycin	Homo sapiens	79-83
34492822-7	2021	Here, the migratory pathway for the acid-extractable fraction Cd(II) to be released from contaminated soil to water and adsorbed simultaneously on the surface of PP-g-AA fibers-ball was established.	Water	110-115	serglycin	Homo sapiens	162-166
34492950-3	2021	Therefore, in this study, the MIIP strategy was employed for simultaneous extraction and enrichment of Sb(III), Cd(II), Pb(II) and Te(IV) ions from drinking water sources.	Water	157-162	submaxillary gland androgen regulated protein 3B	Homo sapiens	120-126
34342225-3	2021	In the present study, we combine field-dependent NMR relaxation (NMRD) and theory to probe water dynamics on the surface of proteins in concentrated aqueous solutions of hen egg-white lysozyme (LZM) and bovine serum albumin (BSA).	Water	91-96	lysozyme	Homo sapiens	184-192
34342225-3	2021	In the present study, we combine field-dependent NMR relaxation (NMRD) and theory to probe water dynamics on the surface of proteins in concentrated aqueous solutions of hen egg-white lysozyme (LZM) and bovine serum albumin (BSA).	Water	91-96	lysozyme	Homo sapiens	194-197
34342225-3	2021	In the present study, we combine field-dependent NMR relaxation (NMRD) and theory to probe water dynamics on the surface of proteins in concentrated aqueous solutions of hen egg-white lysozyme (LZM) and bovine serum albumin (BSA).	Water	91-96	albumin	Homo sapiens	210-223
34342225-4	2021	The experiments reveal that the presence of salts (NaCl or NaI) leads to an opposite ion-specific response for the two proteins: an addition of salt to LZM solutions increases water relaxation rates with respect to the salt-free case, while for BSA solutions, a decrease is observed.	Water	176-181	lysozyme	Homo sapiens	152-155
34421841-1	2021	Woodchip bioreactors are increasingly used to remove nitrate (NO3 -) from agricultural drainage water in order to protect aquatic ecosystems from excess nitrogen.	Water	96-101	NBL1, DAN family BMP antagonist	Homo sapiens	62-65
34333978-3	2021	Different from natural desert beetle-inspired water-harvesting materials, these surfaces utilize limited hydrophilic domains to condense fog, and transport of formed tiny droplets relies on a hydrophobic background.	Water	46-51	zinc finger protein, FOG family member 1	Homo sapiens	137-140
34440774-2	2021	AQP0 has several functions in the lens including water transport and adhesion.	Water	49-54	major intrinsic protein of lens fiber	Homo sapiens	0-4
34373563-3	2021	We found that EtOH in the water for 2 h (22-24 h post fertilization) increases the number of Hcrt neurons on the left but not right side of the brain through a stimulation of cell proliferation, this is accompanied by a decrease in locomotor activity under novel conditions but not after habituation, and these effects are evident in both larvae and adults indicating they are long lasting.	Water	26-31	hypocretin (orexin) neuropeptide precursor	Danio rerio	93-97
34421841-10	2021	This trait may be favorable for the development of common microbiological strategies to increase the NO3 - removal from agricultural drainage water.	Water	142-147	NBL1, DAN family BMP antagonist	Homo sapiens	101-104
34442749-7	2021	Correlation analyses further showed that diel expressions of carbon, nitrogen, phosphorous, and micronutrient (iron and vitamin B12) metabolizing genes were significantly coordinated between Microcystis and the microbiome in the whole-water microcosm.	Water	235-240	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	128-131
34314184-6	2021	When the surface H-bonding is disrupted, Bid becomes sensitive to the temperature-dependent internal hydrophobicity such that it exhibits a reversible cold unfolding above water"s freezing point.	Water	172-177	BH3 interacting domain death agonist	Homo sapiens	41-44
34443342-0	2021	A Fast and Convenient Synthesis of New Water-Soluble, Polyanionic Dendrimers.	Water	39-44	Fas activated serine/threonine kinase	Homo sapiens	2-6
34301147-8	2021	Meanwhile, through the study of insulin centroid trajectory, we have claimed two different diffusion mechanisms of insulin in polymer solution: The movement of insulin in the HA and water solution follows the Brownian motion rule.	Water	182-187	insulin	Homo sapiens	32-39
34441574-6	2021	The results proved that increasing the storage temperature accelerated the loss of water and glycerol, and decreased the mechanical properties of the SPI film.	Water	83-88	chromogranin A	Homo sapiens	150-153
34301147-8	2021	Meanwhile, through the study of insulin centroid trajectory, we have claimed two different diffusion mechanisms of insulin in polymer solution: The movement of insulin in the HA and water solution follows the Brownian motion rule.	Water	182-187	insulin	Homo sapiens	115-122
34301147-8	2021	Meanwhile, through the study of insulin centroid trajectory, we have claimed two different diffusion mechanisms of insulin in polymer solution: The movement of insulin in the HA and water solution follows the Brownian motion rule.	Water	182-187	insulin	Homo sapiens	160-167
34301147-9	2021	In comparison, the hopping effect of insulin has been observed in the PVA solution due to poor intermolecular affinity as well as lower polymer water solubility.	Water	144-149	insulin	Homo sapiens	37-44
34121354-0	2021	Asymmetric sulfoxidation of thioether catalyzed by soybean pod shell peroxidase to form enantiopure sulfoxide in water-in-oil microemulsions:kinetic model.	Water	113-118	peroxidase	Glycine max	69-79
34060391-4	2021	RT-qPCR identified that miR-379-5p level was increased in serum of EAU mice.	Water	67-70	microRNA 379	Mus musculus	24-31
34120034-8	2021	To our knowledge, this study is the first to localize and quantify the expression of cyp19a1a and cyp19a1b in the cells of brain and ovary after fish exposure to different BPA concentrations in water.	Water	194-199	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	98-106
34060391-9	2021	Furthermore, we demonstrated that knockdown of miR-379-5p significantly reversed the increased clinical scores and inflammatory response resulting from EAU treatment and this effect was further countervailed by SEMA3A silencing.	Water	152-155	microRNA 379	Mus musculus	47-54
34149894-7	2021	The water isolated site (WA) and ethyl acetate isolated site (EA) significantly reversed complete Freund"s adjuvant (CFA)-induced changes in the levels of NO, IL-6, TNF-alpha, IgG and IFN-gamma, while the n-butanol isolated site (NB) only reversed the changes in IL-6 and IgG contents.	Water	4-9	interleukin 6	Rattus norvegicus	159-163
34087204-1	2021	Lens-specific beaded filament (BF) proteins CP49 and filensin interact with the C-terminus of the water channel Aquaporin 0 (AQP0).	Water	98-103	beaded filament structural protein 2, phakinin	Mus musculus	44-48
34087204-1	2021	Lens-specific beaded filament (BF) proteins CP49 and filensin interact with the C-terminus of the water channel Aquaporin 0 (AQP0).	Water	98-103	major intrinsic protein of lens fiber	Mus musculus	112-123
34087204-1	2021	Lens-specific beaded filament (BF) proteins CP49 and filensin interact with the C-terminus of the water channel Aquaporin 0 (AQP0).	Water	98-103	major intrinsic protein of lens fiber	Mus musculus	125-129
34087204-3	2021	This investigation was undertaken to find out whether the total loss of the BF structural proteins alter the optical properties of the lens and cause optical aberrations similar to those in AQP0DeltaC/DeltaC lenses; also, to map the changes in the optical quality as a function of age in the single or double BF protein knockouts (KOs) as well as to assess whether there is any significant change in the water channel function of AQP0 in these KOs.	Water	404-409	major intrinsic protein of lens fiber	Mus musculus	430-434
34149894-7	2021	The water isolated site (WA) and ethyl acetate isolated site (EA) significantly reversed complete Freund"s adjuvant (CFA)-induced changes in the levels of NO, IL-6, TNF-alpha, IgG and IFN-gamma, while the n-butanol isolated site (NB) only reversed the changes in IL-6 and IgG contents.	Water	4-9	tumor necrosis factor	Rattus norvegicus	165-174
34366002-3	2021	Pot experiments using wheat plants subjected to drought stress showed that SiO2 nanopriming enhanced the ability of wheat plants to withstand water deficit conditions by balancing the production of reactive oxygen species and the activity of enzymatic antioxidants like peroxidase, catalase, and superoxide dismutase.	Water	142-147	catalase	Homo sapiens	282-290
34361559-6	2021	The stability of (BA beta-CD) complex in H2O-EtOH and H2O-DMSO solvents, obtained by different methods, are compared.	Water	41-44	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	21-28
34287875-5	2021	Protein contents, pH (based on FFA and OA), salt in the moisture (S/M), and water activity (aw ) (based on VC and SA) were highly correlated with PC2, resulted in two distinct groups.	Water	76-81	polycystin 2, transient receptor potential cation channel	Homo sapiens	146-149
34143299-4	2021	The GH/IGF-1 system regulates glomerular hemodynamics, renal gluconeogenesis, tubular sodium and water, phosphate, and calcium handling, as well as renal synthesis of 1,25 (OH)2 vitamin D3 and the antiaging hormone Klotho.	Water	97-102	insulin like growth factor 1	Homo sapiens	7-12
34097964-3	2021	PLGA-beta-CD and PEI-BM were synthesized by amidation reaction, the amphipathic polymer nanoparticles with 108.37 +- 1.02 nm were self-assembled in water.	Water	148-153	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	5-12
34372120-4	2021	PLA fiber mats with 3% OTOA content were characterized by a highly porous surface morphology, an increased specific surface area and high-water sorption.	Water	138-143	otoancorin	Homo sapiens	23-27
34291322-2	2021	Saturated buffers are a relatively new conservation practice that diverts tile water into a distribution tile installed in a riparian buffer parallel to a stream with the intent of enhancing NO3-N processing within the buffer.	Water	79-84	NBL1, DAN family BMP antagonist	Homo sapiens	191-194
34291322-5	2021	Results showed that the two saturated buffers are reducing NO3-N concentrations in tile drainage water from input concentrations of approximately 15 mg/l to levels < 1.5 mg/l at the streamside well locations.	Water	97-102	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
34385833-8	2021	Effects of the four water extracts on 15-LOX activity were determined.	Water	20-25	arachidonate 15-lipoxygenase	Homo sapiens	38-44
34258994-2	2021	Fog harvesting is attracting great attention as a method to collect water without any energy input.	Water	68-73	zinc finger protein, FOG family member 1	Homo sapiens	0-3
34107280-6	2021	Using a non-cleavable substrate analog, 2"-deoxy-pseudouridine, we determined the first structure of an enzyme-substrate complex for wild-type MBD4, which confirms interactions that mediate lesion recognition and suggests that a catalytic Asp, highly conserved in HhH enzymes, binds the putative nucleophilic water molecule and stabilizes the transition state.	Water	309-314	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	143-147
34360593-1	2021	Water transport in epithelia occurs transcellularly (aquaporins) and paracellularly (claudin-2, claudin-15).	Water	0-5	claudin 2	Homo sapiens	85-94
34360593-1	2021	Water transport in epithelia occurs transcellularly (aquaporins) and paracellularly (claudin-2, claudin-15).	Water	0-5	claudin 15	Homo sapiens	96-106
34360593-2	2021	Recently, we showed that downregulated tricellulin, a protein of the tricellular tight junction (tTJ, the site where three epithelial cells meet), increased transepithelial water flux.	Water	173-178	MARVEL domain containing 2	Homo sapiens	39-50
34258996-6	2021	The YTHDC1"s preference for the 5"-Gm6A-3" motif is partially facilitated by a network of water-mediated interactions between the 2-amino group of the guanosine and residues in the m6A binding pocket.	Water	90-95	YTH domain containing 1	Homo sapiens	4-10
34361559-3	2021	In this paper, NMR results for the molecular complex formation between BA and beta-CD ((BA beta-CD)) in D2O-DMSO-d6 and in D2O-EtOH have shown that the stability of the complex in the H2O-DMSO-d6 varies within the experimental error, while decreases in H2O-EtOH.	Water	184-187	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-85
34361559-3	2021	In this paper, NMR results for the molecular complex formation between BA and beta-CD ((BA beta-CD)) in D2O-DMSO-d6 and in D2O-EtOH have shown that the stability of the complex in the H2O-DMSO-d6 varies within the experimental error, while decreases in H2O-EtOH.	Water	184-187	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	91-98
34361559-3	2021	In this paper, NMR results for the molecular complex formation between BA and beta-CD ((BA beta-CD)) in D2O-DMSO-d6 and in D2O-EtOH have shown that the stability of the complex in the H2O-DMSO-d6 varies within the experimental error, while decreases in H2O-EtOH.	Water	253-256	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-85
34361559-3	2021	In this paper, NMR results for the molecular complex formation between BA and beta-CD ((BA beta-CD)) in D2O-DMSO-d6 and in D2O-EtOH have shown that the stability of the complex in the H2O-DMSO-d6 varies within the experimental error, while decreases in H2O-EtOH.	Water	253-256	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	91-98
34361559-4	2021	Changes in the Gibbs energy of BA resolvation in water and water-dimethylsulfoxide mixtures have been obtained and have been used in the analysis of the reagent solvation contributions into the Gibbs energy changes of the (BA beta-CD) molecular complex formation.	Water	49-54	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	226-233
34361559-4	2021	Changes in the Gibbs energy of BA resolvation in water and water-dimethylsulfoxide mixtures have been obtained and have been used in the analysis of the reagent solvation contributions into the Gibbs energy changes of the (BA beta-CD) molecular complex formation.	Water	59-64	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	226-233
34361559-6	2021	The stability of (BA beta-CD) complex in H2O-EtOH and H2O-DMSO solvents, obtained by different methods, are compared.	Water	54-57	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	21-28
34143166-0	2021	Converting p-terphenyl into a novel organo-catalyst for LED-driven energy and electron transfer photoreactions in water.	Water	114-119	small integral membrane protein 10 like 2A	Homo sapiens	56-59
34267173-11	2021	Notably, we found that neurobehavioral scores, brain water content, and neuronal apoptosis were decreased and caspase3 activity was reduced in MEG3-shRNA-treated ICH rats, while we observed the opposite result in ICH+MEG3-shRNA+miR-181b inhibitor rats.	Water	53-58	similar to GTL2, imprinted maternally expressed untranslated	Rattus norvegicus	143-147
34267173-11	2021	Notably, we found that neurobehavioral scores, brain water content, and neuronal apoptosis were decreased and caspase3 activity was reduced in MEG3-shRNA-treated ICH rats, while we observed the opposite result in ICH+MEG3-shRNA+miR-181b inhibitor rats.	Water	53-58	similar to GTL2, imprinted maternally expressed untranslated	Rattus norvegicus	217-221
34356889-8	2021	Also, the EE had a positive effect on mice exposed to water through the transient receptor potential vanilloid 1 (TRPV1) and anandamide (AEA)-dependent MPP long-term potentiation (MPP-LTP).	Water	54-59	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	72-112
34356889-8	2021	Also, the EE had a positive effect on mice exposed to water through the transient receptor potential vanilloid 1 (TRPV1) and anandamide (AEA)-dependent MPP long-term potentiation (MPP-LTP).	Water	54-59	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	114-119
34101209-5	2021	Using NMR, we determined a high-resolution structure of the Bax core region, revealing a dimer with the nonpolar surface covering the lipid bilayer edge and the polar surface exposed to water.	Water	186-191	BCL2 associated X, apoptosis regulator	Homo sapiens	60-63
34336785-1	2021	A 3D supermolecular structure (Co3(L)2 (2,2"-bipy)2)(DMF)3(H2O)3 1) (H3L = 4,4",4""-nitrilotribenzoic acid) has been constructed based on H3L, and 2,2"-bipy ligands under solvothermal conditions.	Water	59-62	H3 clustered histone 2	Homo sapiens	69-72
34336785-1	2021	A 3D supermolecular structure (Co3(L)2 (2,2"-bipy)2)(DMF)3(H2O)3 1) (H3L = 4,4",4""-nitrilotribenzoic acid) has been constructed based on H3L, and 2,2"-bipy ligands under solvothermal conditions.	Water	59-62	H3 clustered histone 2	Homo sapiens	138-141
34225448-3	2021	Here, the joint effect of galvanic corrosion and redeposition has been utilized to develop bimetallic transient nanocomposites, which can be printed and water-sintered to yield high-performance transient PCB circuits with excellent electrical conductivity and mechanical robustness.	Water	153-158	pyruvate carboxylase	Homo sapiens	204-207
34299138-6	2021	By immunizing IL-27Ralpha-/- mice and their wild-type (WT) littermates for EAU, we demonstrated that IL-27 signaling deficiency exacerbated EAU with severe ocular inflammation and impairment of visual function.	Water	140-143	interleukin 27 receptor, alpha	Mus musculus	14-25
34160508-2	2021	The one-pot synthesis involves the following steps: heating RuCl3 3H2O at 80  C in 2-ethoxyethanol for 2 h, addition of three equivalents of KOH, heating at 135  C for 2 h, addition of a fourth equivalent of KOH and heating at 135  C for 1 h. The resulting K(1) salt is transformed into (NEt4)(1) upon metathesis with (NEt4)Br in H2O.	Water	330-333	tetraspanin 5	Homo sapiens	288-292
34189916-5	2021	Fog harvesting studies show that the patterned substrate has a higher water collection rate, a factor of 1.32, than the nonpatterned substrates.	Water	70-75	zinc finger protein, FOG family member 1	Homo sapiens	0-3
34253193-2	2021	In CF, mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein impair transepithelial electrolyte and water transport, resulting in airway dehydration, and a thickening of the mucus associated with abnormal viscoelastic properties.	Water	148-153	CF transmembrane conductance regulator	Homo sapiens	42-93
34152719-3	2021	Albumin is the most abundant protein in blood serum and serves as a carrier for several molecules that exhibit poor water solubility.	Water	116-121	albumin	Homo sapiens	0-7
34253193-2	2021	In CF, mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein impair transepithelial electrolyte and water transport, resulting in airway dehydration, and a thickening of the mucus associated with abnormal viscoelastic properties.	Water	148-153	CF transmembrane conductance regulator	Homo sapiens	95-99
34307302-3	2021	Prior to CO2 hydration, the proton transfer from the water molecule (WT1) to H64 is the rate-limiting step with the free energy barrier of 10.4 kcal/mol, which leads to the ready state with the Zn-bound OH-.	Water	53-58	WT1 transcription factor	Homo sapiens	69-72
34356639-4	2021	Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.	Water	224-229	catalase	Homo sapiens	64-72
34356639-4	2021	Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.	Water	224-229	catalase	Homo sapiens	74-77
34356639-4	2021	Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.	Water	231-234	catalase	Homo sapiens	64-72
34356639-4	2021	Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.	Water	231-234	catalase	Homo sapiens	74-77
34308050-8	2021	The achieved results are important for the research toward integrated monitoring and sensing platforms for Pb(II) contamination in drinking water.	Water	140-145	submaxillary gland androgen regulated protein 3B	Homo sapiens	107-113
34245030-11	2022	Inoculated plants increased their root colonization ability and biomass; however, PS2 showed higher survival (95%), relative water content (59%), chlorophyll (30%), glycine betaine (38%), proline (23%), and reduced MDA (43%) in shoots than irrigated control under induced water deprivation.	Water	125-130	inorganic pyrophosphatase 1	Arabidopsis thaliana	82-85
34244555-6	2021	Higher plasma corticosterone levels were seen in mice subjected to PCMS, whereas TNF-alpha expression was found higher in the hypothalamus in the W and the trigeminal ganglion in the MW group.	Water	146-147	tumor necrosis factor	Mus musculus	81-90
34244555-7	2021	The W group had higher expression levels of IL-6 in the thalamus as well.	Water	4-5	interleukin 6	Mus musculus	44-48
34305821-7	2021	CB1R could also participate to water and sodium balance and to blood pressure regulation but its precise role remains to decipher.	Water	31-36	cannabinoid receptor 1	Homo sapiens	0-4
34233546-7	2021	The partial replacement of WPI by SPI changed the microstructure of the foams and had an antagonistic effect on the FS of the samples, due to the negative effect of insoluble soy protein aggregates and/or insoluble co-aggregates on the reinforcement of the air-water interfacial film.	Water	261-266	chromogranin A	Homo sapiens	34-37
34357160-4	2021	The AGO-3 membrane showed the highest water flux of about 153 Lm-2h-1.	Water	38-43	argonaute RISC catalytic component 3	Homo sapiens	4-9
34184020-5	2021	At lower temperatures, we found an unusual temperature dependence of S and thetac for each PYS alkane on SPC/E water.	Water	111-116	surfactant protein C	Homo sapiens	105-108
34184020-7	2021	For octane-SPC/E water, this unusual behavior of thetac occurs due to the presence of second inflection points (SIP) in the vapor-water and the octane-water interfacial tensions, whereas the SIP effect is much less important for the nonane-water system.	Water	17-22	surfactant protein C	Homo sapiens	11-14
34184020-7	2021	For octane-SPC/E water, this unusual behavior of thetac occurs due to the presence of second inflection points (SIP) in the vapor-water and the octane-water interfacial tensions, whereas the SIP effect is much less important for the nonane-water system.	Water	130-135	surfactant protein C	Homo sapiens	11-14
34184020-7	2021	For octane-SPC/E water, this unusual behavior of thetac occurs due to the presence of second inflection points (SIP) in the vapor-water and the octane-water interfacial tensions, whereas the SIP effect is much less important for the nonane-water system.	Water	151-156	surfactant protein C	Homo sapiens	11-14
34184020-8	2021	The unusual temperature dependence of thetac observed for nonane on SPC/E water is also found for nonane on TIP4P/2005 water.	Water	74-79	surfactant protein C	Homo sapiens	68-71
34361144-6	2021	In addition, porous microcapsules with different pore sizes were prepared by adding a varying amount of porogen bovine serum albumin (BSA) to the internal water phase.	Water	155-160	albumin	Homo sapiens	119-132
34170128-8	2021	All these results demonstrate lysozyme amyloid fibrils as an appropriate natural bio-flocculant for removing dispersed MPs, NOM, and turbid particles from water.	Water	155-160	lysozyme	Homo sapiens	30-38
34229994-8	2021	Other important pathways such as vasopressin regulated water reabsorption, fluid shear stress, relaxin signaling, and renin secretion were also highlighted.	Water	55-60	arginine vasopressin	Homo sapiens	33-44
34284710-0	2021	Involvement of Carbonic Anhydrase CAH3 in the Structural and Functional Stabilization of the Water-Oxidizing Complex of Photosystem II from Chlamydomonas reinhardtii.	Water	93-98	uncharacterized protein	Chlamydomonas reinhardtii	34-38
34284710-2	2021	However, so far only for CAH3 from Chlamydomonas reinhardtii there is evidence for its association with the donor side of PSII, where the CA activity of CAH3 can influence the functioning of the water-oxidizing complex (WOC).	Water	195-200	uncharacterized protein	Chlamydomonas reinhardtii	25-29
34284710-2	2021	However, so far only for CAH3 from Chlamydomonas reinhardtii there is evidence for its association with the donor side of PSII, where the CA activity of CAH3 can influence the functioning of the water-oxidizing complex (WOC).	Water	195-200	uncharacterized protein	Chlamydomonas reinhardtii	153-157
34215821-3	2021	Therefore, the aim of this study was to examine the metabolic effects of chronic treatment with the GC corticosterone (Cort, 75 mug/ml in drinking water) in mice lacking the glucocorticoid receptor (GR) on AgRP neurons.	Water	147-152	agouti related neuropeptide	Mus musculus	206-210
34242940-2	2021	This study was aimed to examine the impacts of two water-based exercise programs (interval vs. continuous) without dietary intervention on body weight and blood lipid parameters, and its potential interactive effects and the activity of cholesteryl ester transfer protein (CETP) in obese older men with a sedentary lifestyle.	Water	51-56	cholesteryl ester transfer protein	Homo sapiens	237-271
34242940-2	2021	This study was aimed to examine the impacts of two water-based exercise programs (interval vs. continuous) without dietary intervention on body weight and blood lipid parameters, and its potential interactive effects and the activity of cholesteryl ester transfer protein (CETP) in obese older men with a sedentary lifestyle.	Water	51-56	cholesteryl ester transfer protein	Homo sapiens	273-277
34281190-3	2021	Vasopressin secretion is maintained in pregnancy and lactation despite reduced osmolality (the principal stimulus for vasopressin secretion) to increase water retention to cope with the cardiovascular demands of pregnancy and lactation.	Water	153-158	arginine vasopressin	Rattus norvegicus	118-129
34281190-9	2021	Furthermore, supraoptic nucleus DeltaN-TRPV1 mRNA expression was not different between non-pregnant and late-pregnant rats, suggesting that sustained activity of DeltaN-TRPV1 channels might maintain vasopressin neuron activity to increase water retention during pregnancy and lactation.	Water	239-244	arginine vasopressin	Rattus norvegicus	199-210
34293079-0	2021	Age-Dependent Changes in Total and Free Water Content of In Vivo Human Lenses Measured by Magnetic Resonance Imaging.	Water	40-45	renin binding protein	Homo sapiens	0-3
34293079-1	2021	Purpose: To use magnetic resonance imaging (MRI) to measure age-dependent changes in total and free water in human lenses in vivo.	Water	100-105	renin binding protein	Homo sapiens	60-63
34085703-3	2021	Structural data at 2.74 A resolution reveals strong hydrophobic interactions in the plant PSI-Pc ternary complex, leading to exclusion of water molecules from PsaA-PsaB / Pc interface once the PSI-Pc complex forms.	Water	138-143	pyruvate carboxylase	Homo sapiens	171-173
34293079-7	2021	However, this initially parabolic free water gradient gradually developed an enhanced central plateau, as indicated by increasing profile shape parameter values (anterior: 0.067/y, P = 0.004; posterior: 0.050/y, P = 0.020) and central free water content (1.932 ms/y, P = 0.022) with age.	Water	39-44	renin binding protein	Homo sapiens	283-286
34293079-7	2021	However, this initially parabolic free water gradient gradually developed an enhanced central plateau, as indicated by increasing profile shape parameter values (anterior: 0.067/y, P = 0.004; posterior: 0.050/y, P = 0.020) and central free water content (1.932 ms/y, P = 0.022) with age.	Water	240-245	renin binding protein	Homo sapiens	283-286
34293079-9	2021	The observation that the lens steady-state free, but not total, water gradient is abolished with age raises the possibility that alterations in protein-water interactions are an underlying cause of the degradation in lens optics and overall vision observed with aging.	Water	64-69	renin binding protein	Homo sapiens	97-100
34293079-9	2021	The observation that the lens steady-state free, but not total, water gradient is abolished with age raises the possibility that alterations in protein-water interactions are an underlying cause of the degradation in lens optics and overall vision observed with aging.	Water	152-157	renin binding protein	Homo sapiens	97-100
34106680-6	2021	The CsPb1-xErxBr3-ZBLAN fluoride glass can prevent the perovskite from being destroyed by water, oxygen, and laser.	Water	90-95	mitogen-activated protein kinase 14	Homo sapiens	4-9
34105560-7	2021	A focused analysis on the highly conserved water network in the binding site of BRD4-BD1 is performed to identify the positions of these water molecules across the crystal structures.	Water	43-48	bromodomain containing 4	Homo sapiens	80-84
34105560-7	2021	A focused analysis on the highly conserved water network in the binding site of BRD4-BD1 is performed to identify the positions of these water molecules across the crystal structures.	Water	43-48	defensin beta 1	Homo sapiens	85-88
34105560-7	2021	A focused analysis on the highly conserved water network in the binding site of BRD4-BD1 is performed to identify the positions of these water molecules across the crystal structures.	Water	137-142	bromodomain containing 4	Homo sapiens	80-84
34105560-7	2021	A focused analysis on the highly conserved water network in the binding site of BRD4-BD1 is performed to identify the positions of these water molecules across the crystal structures.	Water	137-142	defensin beta 1	Homo sapiens	85-88
34159985-3	2021	Here, the self-consistent field theory of Scheutjens and Fleer (SF-SCF) in which a lattice refinement has been implemented, is used to scrutinize how various additives modify the self-assembled phase behaviour of monoolein (MO) and 1,2-dioleoyl-phosphatidylcholine (DOPC) lipids in water.	Water	282-287	tetratricopeptide repeat domain 30B	Homo sapiens	57-62
34248399-1	2021	In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are (Co3(opda)3(mbib)4(H2O)4) 2H2O (1, H2opda is 1,2-phenylenediacetic acid) and (Co(mpda)(mbib)) H2O (2, H2mpda is 1,3-phenylenediacetic acid).	Water	320-323	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
34248399-1	2021	In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are (Co3(opda)3(mbib)4(H2O)4) 2H2O (1, H2opda is 1,2-phenylenediacetic acid) and (Co(mpda)(mbib)) H2O (2, H2mpda is 1,3-phenylenediacetic acid).	Water	320-323	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
34248399-1	2021	In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are (Co3(opda)3(mbib)4(H2O)4) 2H2O (1, H2opda is 1,2-phenylenediacetic acid) and (Co(mpda)(mbib)) H2O (2, H2mpda is 1,3-phenylenediacetic acid).	Water	395-398	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
34248399-1	2021	In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are (Co3(opda)3(mbib)4(H2O)4) 2H2O (1, H2opda is 1,2-phenylenediacetic acid) and (Co(mpda)(mbib)) H2O (2, H2mpda is 1,3-phenylenediacetic acid).	Water	395-398	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
34323033-2	2021	Methods: The formulation of insulin-loaded water-in-oil-in-water solid lipid nanoparticles (INS-SNPs) was prepared by using a methanol-chloroform mixed solvent.	Water	43-48	insulin	Homo sapiens	28-35
34323033-2	2021	Methods: The formulation of insulin-loaded water-in-oil-in-water solid lipid nanoparticles (INS-SNPs) was prepared by using a methanol-chloroform mixed solvent.	Water	59-64	insulin	Homo sapiens	28-35
34619845-9	2021	For patients with suspected CNDI, water-inhibiting vasopressin test and genetic testing should be performed in time so as to confirm diagnosis and treat as early as possible.	Water	34-39	arginine vasopressin	Homo sapiens	51-62
34206920-9	2021	Finally, the differential pulse adsorptive stripping voltammetric (DPAdSV) procedure using the aSPCE/SDS was successfully applied for the determination of PA, DF, and TR in river water and serum samples as well as pharmaceuticals.	Water	179-184	coagulation factor II thrombin receptor	Homo sapiens	167-169
34085703-4	2021	Upon oxidation of Pc, a slight tilt of bound oxidized Pc allows water molecules to accommodate the space between Pc and PSI to drive Pc dissociation.	Water	64-69	pyruvate carboxylase	Homo sapiens	18-20
34085703-4	2021	Upon oxidation of Pc, a slight tilt of bound oxidized Pc allows water molecules to accommodate the space between Pc and PSI to drive Pc dissociation.	Water	64-69	pyruvate carboxylase	Homo sapiens	54-56
34085703-4	2021	Upon oxidation of Pc, a slight tilt of bound oxidized Pc allows water molecules to accommodate the space between Pc and PSI to drive Pc dissociation.	Water	64-69	pyruvate carboxylase	Homo sapiens	113-115
34085703-4	2021	Upon oxidation of Pc, a slight tilt of bound oxidized Pc allows water molecules to accommodate the space between Pc and PSI to drive Pc dissociation.	Water	64-69	pyruvate carboxylase	Homo sapiens	133-135
34234438-12	2021	MiR-126a-5p agomir obviously reduced the neurological deficit, infarct volume, brain water content, oxidative stress, and apoptosis in I/R rats.	Water	85-90	microRNA 126a	Rattus norvegicus	0-8
34114821-0	2021	Twist and Stretch: Assignment and Surface Charge Sensitivity of a Water Combination Band and Its Implications for Vibrational Sum Frequency Spectra Interpretations.	Water	66-71	twist family bHLH transcription factor 1	Homo sapiens	0-5
34202308-1	2021	The effect of bovine serum albumin (BSA) upon interaction between CdTe QD functionalized by 3-Mercaptopropionic Acid (CdTe-3-MPA QD) and two water soluble porphyrins: positively charged meso-tetra methyl pyridyl porphyrin (TMPyP) and negatively charged meso-tetrakis(p-sulfonato-phenyl) porphyrin (TPPS4), was studied in function of pH using the steady-state and time resolved optical absorption and fluorescence spectroscopies.	Water	141-146	albumin	Homo sapiens	21-34
34170847-8	2021	PD-1 antibody or BMS-1 was successfully conjugated to the decellularized rat thoracic artery patch by hyaluronic acid with altered morphology and reduced the water contact angle (WCA).	Water	158-163	BMS1 ribosome biogenesis factor	Rattus norvegicus	17-22
34203003-2	2021	In the first step, a functional electrospun fiber mat composed of poly(acrylic acid) (PAA) and beta-cyclodextrin (beta-CD) was obtained, showing high water insolubility and great adhesion increased by means of a thermal crosslinking process (denoted as PAA + beta-CD).	Water	150-155	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	114-121
34105349-10	2021	Our results demonstrate the versatility of the KAT ligation for the covalent attachment of a variety of water-soluble molecules onto SAM surfaces under dilute and biocompatible conditions to form stable, natural amide bonds.	Water	104-109	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	47-50
34096270-6	2021	In addition, TPI-An-Py can be applied to the detection of Cu2+ in real samples with satisfactory recoveries in the range of 100-112% in lake water and 98-101% in tap water.	Water	141-146	triosephosphate isomerase 1	Homo sapiens	13-16
34096270-6	2021	In addition, TPI-An-Py can be applied to the detection of Cu2+ in real samples with satisfactory recoveries in the range of 100-112% in lake water and 98-101% in tap water.	Water	166-171	triosephosphate isomerase 1	Homo sapiens	13-16
34241272-0	2021	Molecular dynamics study of water channels in natural and synthetic amyloid-beta fibrils.	Water	28-33	amyloid beta precursor protein	Homo sapiens	68-80
34241277-0	2021	Immiscibility in N2-H2O solids up to 140 GPa.	Water	20-23	glycophorin A (MNS blood group)	Homo sapiens	41-44
34205315-7	2021	The mRNA and protein expression levels of cutaneous aquaporin-3 (AQP3), which is involved in wound healing and increases in dermal water content, were significantly increased by treatment with Kumazasa extract.	Water	131-136	aquaporin 3	Mus musculus	65-69
34100579-2	2021	We constructed an acid-/base-stable Co(II)-framework with a unique network topology, wherein unidirectional porous channels are decorated by anionic (Co2(mu2-OH)(COO)4(H2O)3) secondary building units and neutral (CoN2(COO)2) nodes.	Water	168-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
34467355-1	2021	NO3   can compete with omnipotent  OH/SO4  - in decomposing aqueous pollutants because of its lengthy lifespan and significant tolerance to background scavengers present in H2O matrices, albeit with moderate oxidizing power.	Water	173-176	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
34156031-0	2021	Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting.	Water	40-45	serine/threonine kinase 24	Mus musculus	7-12
34156031-4	2021	Here, we found that mice deficient of Pdcd10 or Stk24/25 in the kidney tubules developed polyuria and displayed increased water consumption.	Water	122-127	serine/threonine kinase 24	Mus musculus	48-56
34205326-7	2021	Eighteen radiation-induced genes and sixteen non-radiation-induced gene players have been identified from the ATR/ATM protein interaction complexes involved in heat, salt, water, osmotic stress responses, and plant organogenesis.	Water	172-177	Ataxia telangiectasia-mutated and RAD3-like protein	Arabidopsis thaliana	110-113
34081434-9	2021	The response time of CAC devices can be as fast as 10-100 ms, making them ideal for applications as self-powered water detectors.	Water	113-118	Fas activated serine/threonine kinase	Homo sapiens	43-47
34222311-8	2021	Moreover, it could reveal the interaction between the water structure and Ara h1 from the perspective of water molecules, and explain the effect of temperature on the Ara h1 structure and hydrogen-bonding system.	Water	54-59	allergen Ara h 1, clone P17	Arachis hypogaea	74-80
34222311-8	2021	Moreover, it could reveal the interaction between the water structure and Ara h1 from the perspective of water molecules, and explain the effect of temperature on the Ara h1 structure and hydrogen-bonding system.	Water	54-59	allergen Ara h 1, clone P17	Arachis hypogaea	167-173
34222311-8	2021	Moreover, it could reveal the interaction between the water structure and Ara h1 from the perspective of water molecules, and explain the effect of temperature on the Ara h1 structure and hydrogen-bonding system.	Water	105-110	allergen Ara h 1, clone P17	Arachis hypogaea	74-80
34222311-8	2021	Moreover, it could reveal the interaction between the water structure and Ara h1 from the perspective of water molecules, and explain the effect of temperature on the Ara h1 structure and hydrogen-bonding system.	Water	105-110	allergen Ara h 1, clone P17	Arachis hypogaea	167-173
34137636-0	2021	Genome Sequences for Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Strains Isolated from Different Water Sources.	Water	113-118	EsbL	Escherichia coli	21-53
34075755-6	2021	Importantly, via the SAP-based "water pump" design, we improved the eta of the Co-Sn alloy@PTFE film to 89%, mainly because the SAP not only effectively performed water transportation but also markedly reduced the heat loss of the Co-Sn alloy@PTFE film.	Water	32-37	SH2 domain containing 1A	Homo sapiens	21-24
34075755-6	2021	Importantly, via the SAP-based "water pump" design, we improved the eta of the Co-Sn alloy@PTFE film to 89%, mainly because the SAP not only effectively performed water transportation but also markedly reduced the heat loss of the Co-Sn alloy@PTFE film.	Water	32-37	SH2 domain containing 1A	Homo sapiens	128-131
34075755-6	2021	Importantly, via the SAP-based "water pump" design, we improved the eta of the Co-Sn alloy@PTFE film to 89%, mainly because the SAP not only effectively performed water transportation but also markedly reduced the heat loss of the Co-Sn alloy@PTFE film.	Water	163-168	SH2 domain containing 1A	Homo sapiens	21-24
34075755-6	2021	Importantly, via the SAP-based "water pump" design, we improved the eta of the Co-Sn alloy@PTFE film to 89%, mainly because the SAP not only effectively performed water transportation but also markedly reduced the heat loss of the Co-Sn alloy@PTFE film.	Water	163-168	SH2 domain containing 1A	Homo sapiens	128-131
34207422-1	2021	Denitrifying woodchip bioreactors (WBR), which aim to reduce nitrate (NO3-) pollution from agricultural drainage water, are less efficient when cold temperatures slow down the microbial transformation processes.	Water	113-118	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
34139912-9	2021	In the KEGG enrichment analysis, the DEGs mainly involved glycosaminoglycan degradation, vasopressin-regulated water reabsorption, and pyruvate metabolism.	Water	111-116	arginine vasopressin	Homo sapiens	89-100
34100598-5	2021	The "sp C-O-Mo hybridization" facilitates charge transfer and boosts the dissociation process of H2O molecules, leading to outstanding HER activity with high-current density (>1.2 A cm-2) in alkaline electrolyte and a decent activity and stability in natural seawater.	Water	97-100	surfactant protein C	Homo sapiens	5-9
34208733-5	2021	The linear relationship between the predicted and the actual values of NO3-, NO2-, salinity, and the recovery of spiked water samples suggest that the proposed PLS model can be a valuable alternative method to the wet chemical methods.	Water	120-125	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
34208733-9	2021	The proposed method was applied to the analysis of NO3-, NO2-, and salinity in the Changjiang (Yangtze River) estuary water samples and the results are comparable with that determined by the colorimetric Griess assay.	Water	118-123	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
34179093-3	2021	The resulting multiscale decomposition of energy and entropy components for water, sodium chloride, excipients and lysozyme reveals that lysozyme is more stabilised by the interaction of tripolyphosphate with basic residues.	Water	76-81	lysozyme	Homo sapiens	137-145
34111968-0	2021	Inspecting Insulin Products Using Water Proton NMR.	Water	34-39	insulin	Homo sapiens	11-18
34111968-4	2021	METHODS: Four insulin products for patient self-injection presented as prefilled pens have been noninvasively and quantitatively inspected using the water proton NMR technology.	Water	149-154	insulin	Homo sapiens	14-21
34111968-9	2021	CONCLUSIONS: Water proton NMR can noninvasively and quantitatively inspect insulin pens.	Water	13-18	insulin	Homo sapiens	75-82
34105321-1	2021	OBJECTIVES: The present study aimed to explore the effect of water-based rhythmic exercise training on fasting blood sugar (FBS), homeostatic model assessment (HOMA), insulin, thyroid stimulating hormone (TSH), and T4 in postmenopausal women with metabolic syndrome.	Water	61-66	insulin	Homo sapiens	167-174
34169131-1	2021	We present a CTD dataset of repeated sections across the Vema Channel in the South Atlantic approximately along 31 12" S between longitudes 39 18.0 W and 39 30.0" W. The Vema Channel is a narrow conduit for Antarctic Bottom Water across the Rio Grande Rise.	Water	224-229	CTD	Homo sapiens	13-16
34108029-9	2021	Cox proportional hazard analysis demonstrated that CRS (+ 10 mL/cm H2O) was only associated with being discharge from the ICU within 28 days (HR 1.14, 95% CI 1.02-1.28, p = 0.018).	Water	67-70	twist family bHLH transcription factor 1	Homo sapiens	51-54
34103500-2	2021	Dispelling water at the considerably reduced scale of fog or dew, however, constitutes a significant challenge, owing to the comparable size of droplets and structures.	Water	11-16	zinc finger protein, FOG family member 1	Homo sapiens	54-57
34240976-0	2021	Structural and dynamical heterogeneity of water trapped inside Na+-pumping KR2 rhodopsin in the dark state.	Water	42-47	rhodopsin	Homo sapiens	79-88
34240976-4	2021	In this paper, we systematically investigate the localization, structure, dynamics, and energetics of the water molecules along the channel for the resting/dark state of KR2 rhodopsin.	Water	106-111	rhodopsin	Homo sapiens	174-183
34554478-5	2021	In antimicrobial tests, chloroform, ethyl acetate, butanol, and water extracts inhibited the growth of S. aureus and MRSA, while butanol and water fractions were effective against E. coli, and water extract for E. coli ESBL and K. pneumoniae ESBL.	Water	141-146	EsbL	Escherichia coli	219-223
34199569-1	2021	Vitamin B12 (also known as cobalamin) is an essential water-soluble vitamin that plays a pivotal role for several physiologic functions during one"s lifespan.	Water	54-59	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
34199635-7	2021	Here, the hydrophilicity and the GRP receptor binding affinities were found to be especially strongly influenced by the number of negative charges and peptide copies, showing logD (1-octanol-water-distribution coefficient) and IC50 (half maximal inhibitory concentration) values of -2.2 +- 0.1 and 59.1 +- 1.5 nM for the homodimer, and -1.9 +- 0.1 and 99.8 +- 3.2 nM for the homotetramer, respectively.	Water	191-196	superoxide dismutase 1	Homo sapiens	321-340
34204637-4	2021	Indeed, the direct or water mediated interaction with hydrophilic residues of the relatively narrower beta2 minus side through the elements decorating the aromatic ring and the stabilization of the latter by facing to the not conserved beta2-Phe119 result as key distinctive features for the alpha4beta2 affinity.	Water	22-27	glycoprotein hormone subunit alpha 2	Homo sapiens	102-107
34204637-4	2021	Indeed, the direct or water mediated interaction with hydrophilic residues of the relatively narrower beta2 minus side through the elements decorating the aromatic ring and the stabilization of the latter by facing to the not conserved beta2-Phe119 result as key distinctive features for the alpha4beta2 affinity.	Water	22-27	glycoprotein hormone subunit alpha 2	Homo sapiens	236-241
34554478-5	2021	In antimicrobial tests, chloroform, ethyl acetate, butanol, and water extracts inhibited the growth of S. aureus and MRSA, while butanol and water fractions were effective against E. coli, and water extract for E. coli ESBL and K. pneumoniae ESBL.	Water	193-198	EsbL	Escherichia coli	219-223
34554478-5	2021	In antimicrobial tests, chloroform, ethyl acetate, butanol, and water extracts inhibited the growth of S. aureus and MRSA, while butanol and water fractions were effective against E. coli, and water extract for E. coli ESBL and K. pneumoniae ESBL.	Water	193-198	EsbL	Escherichia coli	242-246
34075115-3	2021	The effects of two adsorption positions on the EpCAM were analysed, and it is found that the AptEpA adsorption configuration located within the EpCAM pocket-like structure is more stable and the energy barrier is lower due to the interaction with water.	Water	247-252	epithelial cell adhesion molecule	Homo sapiens	47-52
34093973-7	2021	CONCLUSIONS: The results suggest that the inclusion of a water extract of C. zedoaria in a HCD is closely correlated with reducing the risk of vascular inflammatory diseases in an ApoE mouse model.	Water	57-62	apolipoprotein E	Mus musculus	180-184
34075115-3	2021	The effects of two adsorption positions on the EpCAM were analysed, and it is found that the AptEpA adsorption configuration located within the EpCAM pocket-like structure is more stable and the energy barrier is lower due to the interaction with water.	Water	247-252	epithelial cell adhesion molecule	Homo sapiens	144-149
34075115-4	2021	By the root mean square deviation (RMSD), the configuration of EpCAM in water is more conservative when the AptEpA binds to EpCAM by attaching to the pocket space of the EpCAM dimer.	Water	72-77	epithelial cell adhesion molecule	Homo sapiens	63-68
34075115-4	2021	By the root mean square deviation (RMSD), the configuration of EpCAM in water is more conservative when the AptEpA binds to EpCAM by attaching to the pocket space of the EpCAM dimer.	Water	72-77	epithelial cell adhesion molecule	Homo sapiens	170-175
34075115-7	2021	This study has proposed a new numerical process for applying the STUN-BH-DMD with the CG model, which can reduce computational details and directly find a more stable AptEpA/EpCAM complex in water.	Water	191-196	epithelial cell adhesion molecule	Homo sapiens	174-179
34072871-5	2021	Here, we used the response surface methodology to optimize the production of COs by enzymatic hydrolysis of water-soluble chitin (WSC) with hen egg-white lysozyme.	Water	108-113	lysozyme	Homo sapiens	154-162
34070757-5	2021	Anthocyanins, water-soluble flavonoid species, responsible for the red-blue color in plants and commonly found in berries, exert favorable effects on the endothelial function, oxidative stress, inhibit COX-1, and COX-2 enzymes, exert antiatherogenic, antihypertensive, antiglycation, antithrombotic, and anti-inflammatory activity, ameliorate dyslipidemia and arterial stiffness.	Water	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
34073002-4	2021	We performed a combination of experiments and multi-scale molecular modeling to understand the binding of FBG in vacuum and water-solvated surfaces of LNO.	Water	124-129	fibrinogen beta chain	Homo sapiens	106-109
34072552-6	2021	Subsequent to MP treatment, concentrations of chloride ion and expressions of its channel (CFTR and CIC-2) were decreased, whereas expressions of aquaporin (AQP)3 and 8 for water transportation were downregulated by activation of the mitogen-activated protein kinase (MAPK)/nuclear factor (NF)-kappaB signaling pathway.	Water	173-178	aquaporin 3	Mus musculus	157-162
34151097-0	2021	Selective and Fast Detection of Fluoride-Contaminated Water Based on a Novel Salen-Co-MOF Chemosensor.	Water	54-59	Fas activated serine/threonine kinase	Homo sapiens	14-18
34151097-9	2021	Additionally, the applicability of the current Co(II)-MOF approach in different real water samples, such as tap water, drinking water, Nile River water, and wastewater, was extended.	Water	85-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
34151097-9	2021	Additionally, the applicability of the current Co(II)-MOF approach in different real water samples, such as tap water, drinking water, Nile River water, and wastewater, was extended.	Water	112-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
34151097-9	2021	Additionally, the applicability of the current Co(II)-MOF approach in different real water samples, such as tap water, drinking water, Nile River water, and wastewater, was extended.	Water	128-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
34151097-9	2021	Additionally, the applicability of the current Co(II)-MOF approach in different real water samples, such as tap water, drinking water, Nile River water, and wastewater, was extended.	Water	146-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
34071663-5	2021	A water-in-oil reverse microemulsion method was utilized to encapsulate ginsenoside CK via the hydrophobic cavity of beta-CD.	Water	2-7	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	117-124
34167616-5	2021	Our experimental results showed that the PLGAgrafted gamma-Fe2O3 nanoparticles could simulate the activity of catalase and decompose hydrogen peroxide into H2O and oxygen in neutral tumor microenvironment, thus reducing the oxidative damage caused by hydrogenperoxide to lung adenocarcinoma A549 cells.	Water	156-159	catalase	Homo sapiens	110-118
34071911-7	2021	The 70% EtOH, CH2Cl2-soluble fraction, and water-soluble fraction inhibited the production of prostaglandin E2, interleukin-6, and tumor necrosis factor-alpha, as well as markedly blocking LPS-induced expression of inducible NO synthase and cyclooxygenase-2 via inactivation of the nuclear factor-kappa B pathway.	Water	43-48	interleukin 6	Mus musculus	112-125
34113255-0	2021	ANG II and Aldosterone Acting Centrally Participate in the Enhanced Sodium Intake in Water-Deprived Renovascular Hypertensive Rats.	Water	85-90	angiotensinogen	Rattus norvegicus	0-6
34073767-6	2021	The cultivation method strongly influences anthocyanin content in rice plants; water conditions, light quantity and quality, and available nutrients in the soil are important factors, while the low stability of anthocyanins means that they can be dramatically degraded under high-temperature conditions.	Water	79-84	DDB1 and CUL4 associated factor 7	Homo sapiens	43-54
34084477-1	2021	Metabolic alkalosis induced by ingestion of alkaline water may enhance insulin sensitivity in type 1 diabetes mellitus.	Water	53-58	insulin	Homo sapiens	71-78
34067423-4	2021	The 50/50 hybrid HEMA/SBMA hydrogel with 30 mg/mL nanoclay showed outstanding mechanical properties (3 MPa) and water content (60%) compared to pure polyHEMA hydrogels.	Water	112-117	androgen receptor	Homo sapiens	22-26
34093583-5	2021	Systemic suppression of SIRPalpha+ DCs in animals deficient in CD47 resulted in the inability of autoreactive CD4+ T cells to develop, which is crucial to induction of EAU.	Water	168-171	signal regulatory protein alpha	Homo sapiens	24-33
34093583-5	2021	Systemic suppression of SIRPalpha+ DCs in animals deficient in CD47 resulted in the inability of autoreactive CD4+ T cells to develop, which is crucial to induction of EAU.	Water	168-171	CD4 molecule	Homo sapiens	110-113
34093583-7	2021	These results identify CD47 as a significant regulator in the development of SIRPalpha+ DCs that is vital to disease induction in EAU.	Water	130-133	signal regulatory protein alpha	Homo sapiens	77-86
34134954-8	2021	OBJECTIVE: Compared with those in MCAO group, the neurological scores (P < 0.001) and brain water content (P < 0.001) were significantly increased in DJ-1 siRNA group.	Water	92-97	Parkinsonism associated deglycase	Rattus norvegicus	150-154
34071911-7	2021	The 70% EtOH, CH2Cl2-soluble fraction, and water-soluble fraction inhibited the production of prostaglandin E2, interleukin-6, and tumor necrosis factor-alpha, as well as markedly blocking LPS-induced expression of inducible NO synthase and cyclooxygenase-2 via inactivation of the nuclear factor-kappa B pathway.	Water	43-48	tumor necrosis factor	Mus musculus	131-158
34071911-7	2021	The 70% EtOH, CH2Cl2-soluble fraction, and water-soluble fraction inhibited the production of prostaglandin E2, interleukin-6, and tumor necrosis factor-alpha, as well as markedly blocking LPS-induced expression of inducible NO synthase and cyclooxygenase-2 via inactivation of the nuclear factor-kappa B pathway.	Water	43-48	nitric oxide synthase 2, inducible	Mus musculus	215-236
34069360-8	2021	The oil/water emulsion permeability was improved by three-fold from 45 +- 0 to 139 +- 1 L/(m2 h bar) for PSF/PEG-0 membrane in comparison to the most optimum one of PSF/PEG-60.	Water	8-13	insulin like growth factor binding protein 7	Homo sapiens	105-108
34257875-4	2021	The tetracobalt Weakley sandwich (CoII 4(H2O)2(B-alpha-PW9O34)2)10- (Co4-WS) has been one of the most extensively studied.	Water	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-38
34104310-9	2021	The water extract was the most effective in counteracting lipopolysaccharide-induced neuroinflammation in microglial BV-2 cells by strongly reducing the expression of proinflammatory mediators through the modulation of the TLR4/NF-kappaB pathway.	Water	4-9	toll-like receptor 4	Mus musculus	223-227
34104310-9	2021	The water extract was the most effective in counteracting lipopolysaccharide-induced neuroinflammation in microglial BV-2 cells by strongly reducing the expression of proinflammatory mediators through the modulation of the TLR4/NF-kappaB pathway.	Water	4-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	228-237
34069343-1	2021	Soy protein isolate (SPI) powders often have poor water solubility, particularly at pH values close to neutral, which is an attribute that is an issue for its incorporation into complex nutritional systems.	Water	50-55	chromogranin A	Homo sapiens	21-24
34066108-5	2021	In vivo behavioral experiments (Y-maze and Morris water maze test) confirmed that LOS-ME alleviated cognitive impairments induced by scopolamine and the amount of iNOS expression decreased in the hippocampus of the mouse brain.	Water	50-55	nitric oxide synthase 2, inducible	Mus musculus	163-167
34306978-4	2021	X-ray absorption fine spectra reveal that the activation of Co (II) ions (in NH4CoPO4 H2O) to Co (III) species constructs the electrocatalytic active sites.	Water	86-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-67
34063653-5	2021	The experimental results indicated that: (1) when the CAR was 4:6, the optimum water content and the maximum dry density reached their maximum values of 10.1% and 2.03 g/cm3, respectively, the maximum CBR value was 42.5%, and the shear strength reached its maximum value.	Water	79-84	carnation	Drosophila melanogaster	54-57
34062954-7	2021	BChE KO and (R)-bambuterol administered mice rescued age-related spatial memory and general activity in the water maze test and open field test.	Water	108-113	butyrylcholinesterase	Mus musculus	0-4
34846462-7	2021	A reversible torsional fiber artificial muscle showed 122.4  mm-1 rotation, homochiral and heterochiral fiber artificial muscles showed 94% contraction and 3000% elongation, respectively, and a maximum work capacity and energy density of 6.35 J kg-1 and 69.8 kJ m-3, respectively, were realized, on exposure to water fog.	Water	311-316	zinc finger protein, FOG family member 1	Homo sapiens	317-320
34177327-0	2021	Two aquaporins, SIP1;1 and PIP1;2, mediate water transport for pollen hydration in the Arabidopsis pistil.	Water	43-48	small and basic intrinsic protein 1A	Arabidopsis thaliana	16-22
34392523-10	2021	Water-related disasters accounted for nearly three-fourths of the natural disasters (hurricanes 40 percent, N = 12; floods, 33.3 percent, N = 10; total 73.3 percent, N = 22), then snow/ice storms (13.3 percent, N = 4).	Water	0-5	nuclear receptor subfamily 4 group A member 1	Homo sapiens	138-144
34074109-2	2021	Due to technological difficulties with stability in solution, glucagon in currently available preparations was contained in a form of powder, which needs to be first dissolved in the water before application.	Water	183-188	glucagon	Homo sapiens	62-70
34177327-0	2021	Two aquaporins, SIP1;1 and PIP1;2, mediate water transport for pollen hydration in the Arabidopsis pistil.	Water	43-48	plasma membrane intrinsic protein 1B	Arabidopsis thaliana	27-33
34177327-4	2021	Coupled with a time-series imaging analysis of pollination and a reverse genetic analysis using T-DNA insertion Arabidopsis mutants, we found that two aquaporins, the ER-bound SIP1;1 and the plasma membrane-bound PIP1;2, are key players in water transport from papilla cell to pollen during pollination.	Water	240-245	small and basic intrinsic protein 1A	Arabidopsis thaliana	176-182
34177327-4	2021	Coupled with a time-series imaging analysis of pollination and a reverse genetic analysis using T-DNA insertion Arabidopsis mutants, we found that two aquaporins, the ER-bound SIP1;1 and the plasma membrane-bound PIP1;2, are key players in water transport from papilla cell to pollen during pollination.	Water	240-245	plasma membrane intrinsic protein 1A	Arabidopsis thaliana	213-217
34177327-8	2021	In addition, sip1;1 pip1;2 double knockout mutant showed a similar impairment of pollen hydration to individual single mutants, suggesting that their coordinated regulation is critical for proper water transport, in terms of speed and amount, in the pistil to accomplish successful pollen hydration.	Water	196-201	Raffinose synthase family protein	Arabidopsis thaliana	13-17
34177327-8	2021	In addition, sip1;1 pip1;2 double knockout mutant showed a similar impairment of pollen hydration to individual single mutants, suggesting that their coordinated regulation is critical for proper water transport, in terms of speed and amount, in the pistil to accomplish successful pollen hydration.	Water	196-201	plasma membrane intrinsic protein 1A	Arabidopsis thaliana	20-24
34178828-7	2021	Conclusion: To sum up, the present study revealed that pre-meal water intake is associated with lower BMI, body weight, WC, FBS, TG, LDL-C and copeptin levels in patients with T2DM.	Water	64-69	arginine vasopressin	Homo sapiens	143-151
34178828-0	2021	Effect of pre-meal water intake on the serum levels of Copeptin, glycemic control, lipid profile and anthropometric indices in patients with type 2 diabetes mellitus: a randomized, controlled trial.	Water	19-24	arginine vasopressin	Homo sapiens	55-63
34150225-0	2021	Effect of water-soluble PM10 on the production of TNF-alpha by human monocytes and induction of apoptosis in A549 human lung epithelial cells.	Water	10-15	tumor necrosis factor	Homo sapiens	50-59
34178828-1	2021	Background: Water pre-load affects insulin secretion by altering the level of copeptin (C-terminal component of the arginine vasopressin hormone (AVP)) and preventing obesity by reducing food intake.	Water	12-17	insulin	Homo sapiens	35-42
34178828-1	2021	Background: Water pre-load affects insulin secretion by altering the level of copeptin (C-terminal component of the arginine vasopressin hormone (AVP)) and preventing obesity by reducing food intake.	Water	12-17	arginine vasopressin	Homo sapiens	78-86
34178828-1	2021	Background: Water pre-load affects insulin secretion by altering the level of copeptin (C-terminal component of the arginine vasopressin hormone (AVP)) and preventing obesity by reducing food intake.	Water	12-17	arginine vasopressin	Homo sapiens	125-136
34178828-6	2021	At the end of the trial, the concentrations of fasting blood sugar (FBS) (P < 0.0001), triglyceride (TG) (P < 0.05), low-density lipoprotein cholesterol (LDL-C) (P < 0.05) and copeptin (P < 0.05) were significantly reduced following water drinking before meals.	Water	233-238	arginine vasopressin	Homo sapiens	176-184
34163637-0	2021	Single-atom nickel terminating sp2 and sp3 nitride in polymeric carbon nitride for visible-light photocatalytic overall water splitting.	Water	120-125	Sp2 transcription factor	Homo sapiens	31-34
34163637-0	2021	Single-atom nickel terminating sp2 and sp3 nitride in polymeric carbon nitride for visible-light photocatalytic overall water splitting.	Water	120-125	Sp3 transcription factor	Homo sapiens	39-42
34150225-2	2021	The aim of the study was to evaluate the effects of water-soluble PM10 particles in the Middle East Dust (MED) storm in Ahvaz, Iran, on the production of TNF-alpha by human monocytes.	Water	52-57	tumor necrosis factor	Homo sapiens	154-163
34097279-2	2021	As it is used, RDX is widely found in many locations and caused soil and water contamination.	Water	73-78	radixin	Mus musculus	15-18
34238461-1	2021	Vasopressin is the key hormone involved in water conservation and regulation of water balance, essential for life.	Water	43-48	arginine vasopressin	Homo sapiens	0-11
34238461-1	2021	Vasopressin is the key hormone involved in water conservation and regulation of water balance, essential for life.	Water	80-85	arginine vasopressin	Homo sapiens	0-11
34238461-2	2021	In the renal collecting duct, vasopressin binds to the V2 receptor, increasing water permeability through activation of aquaporin-2 redistribution to the luminal membrane.	Water	79-84	arginine vasopressin	Homo sapiens	30-41
35568214-9	2022	The results of the measured and simulated data sets demonstrated the importance of air-water interfacial adsorption for the distribution of the longer-chain PFAS within soil samples.	Water	87-92	phosphoribosylformylglycinamidine synthase	Homo sapiens	157-161
34155432-3	2021	The complexes (M(GA)2(H2O)2), where (M = Mn(II), Co(II), and Ni(II)) form octahedral structures, while (M(GA)2) complexes (M = Zn(II), Cd(II), and Hg(II)) display four-coordination geometry.	Water	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
34989203-11	2021	Drinking 1% H<sub>2</sub>O<sub>2</sub> water significantly (p<u><</u>0.01)decreased the estrous cycle time, body, ovary and uterus weights, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone and estrogen (E2) levels, uterine and ovarian superoxide dismutase (SOD) activity and reduced glutathione (GSH) level while caused a substantial increase (p<u><</u>0.01) in uterine and ovarian malondialdehyde (MDA) level, DNA fragmentation percent, caspase-3 (Casp-3), 8-hydroxydeoxyguanosine (8-OHdG), tumour necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2) levels as well as cyclooxygenase-2 (COX-2) activity.	Water	39-44	tumor necrosis factor	Rattus norvegicus	554-563
34336022-1	2021	Introduction: Catalase (CAT), an antioxidant enzyme, catalyzes conversion of hydrogen peroxide to water and molecular oxygen, protecting cells against oxidative stress.	Water	98-103	catalase	Homo sapiens	14-22
34336022-1	2021	Introduction: Catalase (CAT), an antioxidant enzyme, catalyzes conversion of hydrogen peroxide to water and molecular oxygen, protecting cells against oxidative stress.	Water	98-103	catalase	Homo sapiens	24-27
35576711-1	2022	Researchers have long been committed to identify nitrate sources in groundwater and to develop an advanced technique for its remediation because better apply remediation solution and management of water quality is highly dependent on the identification of the NO3- sources contamination in water.	Water	197-202	NBL1, DAN family BMP antagonist	Homo sapiens	260-263
35489491-7	2022	Shapley Additive Explanations (SHAP) analysis identified pH, SiO2, E, K+, Ca2+, K+/Na+ and NO3- as the most relevant variables for water type discrimination.	Water	131-136	NBL1, DAN family BMP antagonist	Homo sapiens	91-94
35509165-3	2022	An important finding was that alpha- and gamma-gliadins were extracted from wheat flour with water, even to an extent that they in the present work comprised 62-71% of the extract proteins.	Water	93-98	Gli-G1	Triticum aestivum	30-55
35576711-1	2022	Researchers have long been committed to identify nitrate sources in groundwater and to develop an advanced technique for its remediation because better apply remediation solution and management of water quality is highly dependent on the identification of the NO3- sources contamination in water.	Water	290-295	NBL1, DAN family BMP antagonist	Homo sapiens	260-263
35500463-2	2022	The sensor was composed of flexible reference electrode, pH response electrode and K+ selective electrode, which were prepared through printing beta-CD functionalized graphene (beta-CD/RGO) water suspension on conductive PET substrate with microelectronic printer.	Water	190-195	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	144-151
35504133-5	2022	SPC-Sponge not only effectively overcome the limitations of traditional synthetic modification methods on the shape and size of porous sponge materials, but also has excellent oil-water selection function, liquid absorption speed, and liquid absorption capacity compared with common porous materials.	Water	180-185	surfactant protein C	Homo sapiens	0-3
35525057-1	2022	beta-cyclodextrin/graphene oxide (GO-beta-CD) was applied for dispersive micro-solid phase extraction (DMSPE) of uranyl ions (UO22+) from water samples and their determination by energy-dispersive (EDXRF) and total-reflection X-ray fluorescence spectrometry (TXRF).	Water	138-143	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	37-44
35569782-8	2022	Likewise, the liver acetylcholinesterase (AChE) activity decreased by 50% in frogs exposed to salt water and CPF and 40% in those exposed only to CPF, which suggest an additive effect of salinity on inhibition of AChE.	Water	99-104	acetylcholinesterase (Cartwright blood group) L homeolog	Xenopus laevis	20-40
35569782-8	2022	Likewise, the liver acetylcholinesterase (AChE) activity decreased by 50% in frogs exposed to salt water and CPF and 40% in those exposed only to CPF, which suggest an additive effect of salinity on inhibition of AChE.	Water	99-104	acetylcholinesterase (Cartwright blood group) L homeolog	Xenopus laevis	42-46
35569782-8	2022	Likewise, the liver acetylcholinesterase (AChE) activity decreased by 50% in frogs exposed to salt water and CPF and 40% in those exposed only to CPF, which suggest an additive effect of salinity on inhibition of AChE.	Water	99-104	acetylcholinesterase (Cartwright blood group) L homeolog	Xenopus laevis	213-217
35447191-5	2022	We found that the concentration of total phosphorus, which is mainly affected by land-use intensity and influenced by water depth, was the primary (positive) driver of changes in both FDc and FRic, while RUE was mainly explained by phytoplankton FD (i.e., FRic).	Water	118-123	CMD1B	Homo sapiens	184-187
35276195-1	2022	Groundwater is an important source of water supply in the Tak Special Economic Zone of Thailand.	Water	38-43	cyclin dependent kinase 9	Homo sapiens	58-61
35395261-2	2022	This work proposes a new method of preparing Mg-Al-Fe Hydrotalcite-like compounds (MAF-HTCLs) by recycling DWTRs as the raw material to selectively adsorb anions in the waste water.	Water	175-180	MAF bZIP transcription factor	Homo sapiens	83-86
35598422-5	2022	The studies on the interaction with two proteins, lysozyme (Lyz) chosen as a representative model of a small protein, and human serum albumin (HSA) show that two types of binding are possible: a non-covalent binding through the accessible residues on protein surface with (VIVO(L1-3)(LNN)) keeping its octahedral structure, and a covalent binding upon the replacement of water in (VIVO(L1-3)(H2O)) with His-N donors to form VIVO(L1-3)(HSA).	Water	371-376	lysozyme	Homo sapiens	50-58
35598422-5	2022	The studies on the interaction with two proteins, lysozyme (Lyz) chosen as a representative model of a small protein, and human serum albumin (HSA) show that two types of binding are possible: a non-covalent binding through the accessible residues on protein surface with (VIVO(L1-3)(LNN)) keeping its octahedral structure, and a covalent binding upon the replacement of water in (VIVO(L1-3)(H2O)) with His-N donors to form VIVO(L1-3)(HSA).	Water	371-376	lysozyme	Homo sapiens	60-63
35598422-5	2022	The studies on the interaction with two proteins, lysozyme (Lyz) chosen as a representative model of a small protein, and human serum albumin (HSA) show that two types of binding are possible: a non-covalent binding through the accessible residues on protein surface with (VIVO(L1-3)(LNN)) keeping its octahedral structure, and a covalent binding upon the replacement of water in (VIVO(L1-3)(H2O)) with His-N donors to form VIVO(L1-3)(HSA).	Water	371-376	albumin	Homo sapiens	128-141
35598422-5	2022	The studies on the interaction with two proteins, lysozyme (Lyz) chosen as a representative model of a small protein, and human serum albumin (HSA) show that two types of binding are possible: a non-covalent binding through the accessible residues on protein surface with (VIVO(L1-3)(LNN)) keeping its octahedral structure, and a covalent binding upon the replacement of water in (VIVO(L1-3)(H2O)) with His-N donors to form VIVO(L1-3)(HSA).	Water	392-395	lysozyme	Homo sapiens	50-58
35598422-5	2022	The studies on the interaction with two proteins, lysozyme (Lyz) chosen as a representative model of a small protein, and human serum albumin (HSA) show that two types of binding are possible: a non-covalent binding through the accessible residues on protein surface with (VIVO(L1-3)(LNN)) keeping its octahedral structure, and a covalent binding upon the replacement of water in (VIVO(L1-3)(H2O)) with His-N donors to form VIVO(L1-3)(HSA).	Water	392-395	lysozyme	Homo sapiens	60-63
35598422-5	2022	The studies on the interaction with two proteins, lysozyme (Lyz) chosen as a representative model of a small protein, and human serum albumin (HSA) show that two types of binding are possible: a non-covalent binding through the accessible residues on protein surface with (VIVO(L1-3)(LNN)) keeping its octahedral structure, and a covalent binding upon the replacement of water in (VIVO(L1-3)(H2O)) with His-N donors to form VIVO(L1-3)(HSA).	Water	392-395	albumin	Homo sapiens	128-141
35500463-2	2022	The sensor was composed of flexible reference electrode, pH response electrode and K+ selective electrode, which were prepared through printing beta-CD functionalized graphene (beta-CD/RGO) water suspension on conductive PET substrate with microelectronic printer.	Water	190-195	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	177-188
35447448-4	2022	This study therefore proposed a multicriteria life-cycle analysis model, which embeds not only vehicle lifetime distribution but also dynamics of vehicle fuel efficiency and emission factors, to examine the environmental effects of AVRP more comprehensively in terms of material, water, and energy consumption as well as emission of greenhouse gas, air pollutants and water pollutants.	Water	368-373	arginine vasopressin	Homo sapiens	232-236
35351576-0	2022	The water extract of Radix scutellariae, its total flavonoids and baicalin inhibited CYP7A1 expression, improved bile acid, and glycolipid metabolism in T2DM mice.	Water	4-9	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	85-91
35351576-3	2022	Our previous studies found that the water extract of Radix scutellariae (WESB) could exert hypoglycemic and hypolipidemic efficacies by adjusting the ileum FXR-medicated interaction between gut microbiota and bile acid (BA) metabolism.	Water	36-41	nuclear receptor subfamily 1, group H, member 4	Mus musculus	156-159
35364162-4	2022	Here, using a hydrological-hydrodynamic modeling system that includes the major dams in the MRB, we show that while climate variability has been a key driver of inter-decadal variabilities in the lake"s water balance, the operation of Mekong dams has exerted a growing influence-especially after 2010-on the Mekong flood pulse, Tonle Sap River"s flow reversal, and the TSL"s inundation dynamics.	Water	203-208	SH2 domain containing 1A	Homo sapiens	334-337
35364179-10	2022	ESBL-Ec is ubiquitous in drinking water, wastewater and surface water bodies in both rural and urban areas of Bangladesh.	Water	34-39	EsbL	Escherichia coli	0-4
35364179-10	2022	ESBL-Ec is ubiquitous in drinking water, wastewater and surface water bodies in both rural and urban areas of Bangladesh.	Water	64-69	EsbL	Escherichia coli	0-4
35447448-6	2022	In the medium term, the AVRP would slightly increase material, energy and water consumption, sulfur-oxide, greenhouse gas and water pollutants, but significantly or moderately reduce other air pollutants.	Water	74-79	arginine vasopressin	Homo sapiens	24-28
35447448-6	2022	In the medium term, the AVRP would slightly increase material, energy and water consumption, sulfur-oxide, greenhouse gas and water pollutants, but significantly or moderately reduce other air pollutants.	Water	126-131	arginine vasopressin	Homo sapiens	24-28
35576740-6	2022	Among these, we found that the water and ethanol extracts of Polygoni Multiflori Radix (PMR) significantly inhibited S-protein binding to ACE2, 3CL protease activity, and viral entry into the cell and fish models.	Water	31-36	angiotensin I converting enzyme 2	Danio rerio	138-142
35282401-5	2022	There has, therefore, been a high demand for water across the world in a bid to address the problem.	Water	45-50	BH3 interacting domain death agonist	Homo sapiens	73-76
35594706-4	2022	The neuroendocrine roles of VGF and its derived polypeptides in regulating energy, water electrolyte balance, circadian rhythm and reproductive activities were also summarized.	Water	83-88	VGF nerve growth factor inducible	Rattus norvegicus	28-31
35427741-6	2022	This prepared water-soluble luteolin inhibits the polarization of inflammatory macrophages by decreasing the expression of pro-inflammatory cytokine genes interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in vitro.	Water	14-19	interleukin 6	Mus musculus	155-168
35427741-6	2022	This prepared water-soluble luteolin inhibits the polarization of inflammatory macrophages by decreasing the expression of pro-inflammatory cytokine genes interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in vitro.	Water	14-19	interleukin 6	Mus musculus	170-174
35427741-6	2022	This prepared water-soluble luteolin inhibits the polarization of inflammatory macrophages by decreasing the expression of pro-inflammatory cytokine genes interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in vitro.	Water	14-19	tumor necrosis factor	Mus musculus	180-207
35427741-6	2022	This prepared water-soluble luteolin inhibits the polarization of inflammatory macrophages by decreasing the expression of pro-inflammatory cytokine genes interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in vitro.	Water	14-19	tumor necrosis factor	Mus musculus	209-218
35476966-5	2022	Pursuing this objective, we first investigated the therapeutic effect of intranasal insulin on Abeta oligomer (AbetaO)-induced memory impairment in male rats using the Morris water maze task.	Water	175-180	insulin	Homo sapiens	84-91
35381514-5	2022	Most importantly, CCNT significantly increased the oil absorption capacity, improved the mechanical properties, accelerated phonon conduction, enhanced thermal conductivity (80.57 mW m-1 K-1), improved the temperature response rate, shortened the oil desorption time (15 min), and improved the oil/water separation efficiency of PNI-Si@CCNT/CA because a strong interface interaction occurred between CCNT and chitosan.	Water	298-303	cyclin T1	Homo sapiens	18-22
35470695-5	2022	Accordingly, we further hypothesized that, in T2D individuals, seven days of passive heat treatment via hot water immersion to waist-level would improve leg blood flow responses to an oral glucose load (i.e., endogenous insulin stimulation) via induction of endothelial HSP72.	Water	108-113	insulin	Homo sapiens	220-227
35490797-7	2022	Formation of these products occurs via SN1 ionisation to resonance-stabilised allylic cations which are captured by water.	Water	116-121	solute carrier family 38 member 3	Homo sapiens	39-42
35218834-4	2022	The following conclusions are drawn from this study: (i) The proposed model has a high degree of accuracy with the NSE values of key hydraulic variables greater than 0.8 and the GSA indicates that Manning roughness coefficients for surface and sewer flows, inlet weir and orifice discharge coefficients, are the most relevant parameters to influence the simulated results; (ii) vehicles are vulnerable to larger water depths while human stability is significantly influenced by higher flow velocities, with the overall flood risk of people being less than that of vehicles; and (iii) about 88.7% of the total inflow volume was drained to the sewer network, and the sewer drainage system greatly reduced the flood risks to people and vehicles except the local areas with large inundation water depths, where the sewer drainage increased the local flow velocity leading to higher flood risks especially for people.	Water	412-417	GNAS complex locus	Homo sapiens	178-181
35139479-2	2022	In general, the SPI-WPI composite emulsion gel was found to have better water-holding capacity and texture than the emulsion gels formed by the single protein.	Water	72-77	chromogranin A	Homo sapiens	16-19
35271927-6	2022	Colder water limited NO3- removal processes averaging 17.1 mg N m-2 d-1 in the range of 5-14  C, before increasing almost 3-fold in the 20  C treatments at 50.6 mg N m-2 d-1.	Water	7-12	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
35218834-4	2022	The following conclusions are drawn from this study: (i) The proposed model has a high degree of accuracy with the NSE values of key hydraulic variables greater than 0.8 and the GSA indicates that Manning roughness coefficients for surface and sewer flows, inlet weir and orifice discharge coefficients, are the most relevant parameters to influence the simulated results; (ii) vehicles are vulnerable to larger water depths while human stability is significantly influenced by higher flow velocities, with the overall flood risk of people being less than that of vehicles; and (iii) about 88.7% of the total inflow volume was drained to the sewer network, and the sewer drainage system greatly reduced the flood risks to people and vehicles except the local areas with large inundation water depths, where the sewer drainage increased the local flow velocity leading to higher flood risks especially for people.	Water	787-792	GNAS complex locus	Homo sapiens	178-181
35490765-1	2022	The current work aimed to enhance the oral bioavailability of water-insoluble drug Artemisinin (ART) by the inclusion of ART with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and then loaded with porous starch (PS).	Water	62-67	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	166-173
35384203-3	2022	The POM/beta-CD hybrid can be dispersed in water and interact at a water/oil interface with ligands dissolved in an oil phase through electrostatic or host-guest interactions, thereby generating POM-surfactants (POMSs) having pH, redox, and guest-competitive responsiveness, respectively.	Water	43-48	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	8-15
35384203-3	2022	The POM/beta-CD hybrid can be dispersed in water and interact at a water/oil interface with ligands dissolved in an oil phase through electrostatic or host-guest interactions, thereby generating POM-surfactants (POMSs) having pH, redox, and guest-competitive responsiveness, respectively.	Water	67-72	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	8-15
35483153-1	2022	In this study, the subcritical water hydrolysis of N-acetyl-d-glucosamine (NAG), a monomer of abundant renewable marine biopolymer chitin, for production of value-added chemicals is investigated.	Water	31-36	N-acetyl-alpha-glucosaminidase	Homo sapiens	75-78
35594491-0	2022	Gelation Dynamics upon Pressure-Induced Liquid-Liquid Phase Separation in a Water-Lysozyme Solution.	Water	76-81	lysozyme	Homo sapiens	82-90
35594491-1	2022	Employing X-ray photon correlation spectroscopy, we measure the kinetics and dynamics of a pressure-induced liquid-liquid phase separation (LLPS) in a water-lysozyme solution.	Water	151-156	lysozyme	Homo sapiens	157-165
35255332-0	2022	Enhanced Pb(II) removal from water using conductive carbonaceous nanomaterials as bacterial scaffolds: An experimental and modelling approach.	Water	29-34	submaxillary gland androgen regulated protein 3B	Homo sapiens	9-15
35483153-2	2022	The enhanced ionization of water at subcritical conditions (200  C; 50-100 bar), provides enough acidity for deacetylation of NAG resulting in 80% yield of acetic acid along with traces of formic acid, lactic acid, glucose, fructose, 5-hydroxymethylfurfural (5-HMF),etc.	Water	27-32	N-acetyl-alpha-glucosaminidase	Homo sapiens	126-129
35483153-6	2022	Subcritical water enables greener conversion of NAG to platform chemicals wherein the selective production can be achieved by tuning the process conditions.	Water	12-17	N-acetyl-alpha-glucosaminidase	Homo sapiens	48-51
35453033-1	2022	Defects of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein affect the homeostasis of chloride, bicarbonate, sodium, and water in the airway surface liquid, influencing the mucus composition and viscosity, which induces a severe condition of infection and inflammation along the whole life of CF patients.	Water	148-153	CF transmembrane conductance regulator	Homo sapiens	15-71
35453033-1	2022	Defects of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein affect the homeostasis of chloride, bicarbonate, sodium, and water in the airway surface liquid, influencing the mucus composition and viscosity, which induces a severe condition of infection and inflammation along the whole life of CF patients.	Water	148-153	CF transmembrane conductance regulator	Homo sapiens	73-77
35092094-0	2022	Subsecond accurate myelin water fraction reconstruction from FAST-T2 data with 3D UNET.	Water	26-31	Fas activated serine/threonine kinase	Homo sapiens	61-65
35398811-6	2022	The in vitro heat transfer experiment showed that the BHE efficiently cooled the simulated blood from the initial 37  C-5.8  C within 150 s by using cold water (200 ml min-1, 0  C).	Water	154-159	CD59 molecule (CD59 blood group)	Homo sapiens	168-179
35219795-5	2022	Pb exposure altered body and organs weight, food and water consumption, rectal temperature, Pb residue levels in tissues, liver and kidney function, sperm quality parameters, serum metabolic and hematology profiles, and impaired the oxidative/antioxidative balance in the testicular and hepato-renal tissue, as shown by the decreased antioxidant proteins (superoxide dismutase, catalase, glutathione peroxidase, and reduced glutathione) and increased the oxidative (MDA, lipid hydroperoxides, conjugated dienes, protein carbonyl, fragmented DNA and GSH:GSSG ratio) stress and inflammatory (IL-1, IL-6, TNF-alpha, prostaglandin, LTB4, NO, myeloperoxidase, LDH) markers.	Water	53-58	serine peptidase inhibitor, Kunitz type, 2	Rattus norvegicus	0-2
35227848-1	2022	Nitrate (NO3-) pollution in water bodies has received widespread attention, but studies on nitrogen transformation and pollution risk assessment are still limited, especially in rare earth mining areas.	Water	28-33	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
35227848-3	2022	The results showed that the NO3- concentrations ranged from 1.61 to 453.11 mg/L, with 35% of surface water and 53.3% of groundwater samples exceeding the WHO standard (i.e., 50 mg/L).	Water	101-106	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
35092094-1	2022	PURPOSE: To develop a 3D UNET convolutional neural network for rapid extraction of myelin water fraction (MWF) maps from six-echo fast acquisition with spiral trajectory and T2 -prep data and to evaluate its accuracy in comparison with multilayer perceptron (MLP) network.	Water	90-95	Fas activated serine/threonine kinase	Homo sapiens	130-134
35582984-0	2022	Investigating the competing E2 and SN2 mechanisms for the microsolvated HO-(H2O)n=0-4 + CH3CH2X (X = Cl, Br, I) reactions.	Water	76-79	solute carrier family 38 member 5	Homo sapiens	35-38
35582984-1	2022	We characterized the anti-E2, syn-E2, inv-SN2, and ret-SN2 reaction channels for the reaction of microsolvated HO-(H2O)n anions with CH3CH2X (X = Cl, Br, I), using the CCSD(T)/PP/t//MP2/ECP/d level method, to understand how a solvent influences the competing E2 and SN2 reactions.	Water	115-118	solute carrier family 38 member 5	Homo sapiens	42-45
35582984-1	2022	We characterized the anti-E2, syn-E2, inv-SN2, and ret-SN2 reaction channels for the reaction of microsolvated HO-(H2O)n anions with CH3CH2X (X = Cl, Br, I), using the CCSD(T)/PP/t//MP2/ECP/d level method, to understand how a solvent influences the competing E2 and SN2 reactions.	Water	115-118	solute carrier family 38 member 5	Homo sapiens	55-58
35582984-1	2022	We characterized the anti-E2, syn-E2, inv-SN2, and ret-SN2 reaction channels for the reaction of microsolvated HO-(H2O)n anions with CH3CH2X (X = Cl, Br, I), using the CCSD(T)/PP/t//MP2/ECP/d level method, to understand how a solvent influences the competing E2 and SN2 reactions.	Water	115-118	solute carrier family 38 member 5	Homo sapiens	266-269
35582984-7	2022	In terms of E2/SN2 competition, the barrier difference, , first increases then decreases as the number of explicit water molecules increases, under both microsolvation and bulk solvation conditions, but the inv-SN2 pathway is always favored over the anti-E2 pathway.	Water	115-120	solute carrier family 38 member 5	Homo sapiens	15-18
35561157-8	2022	Based on the EPA data set, NO3 - concentration in groundwater and surface water was significantly less after restoration while the control site showed no change.	Water	74-79	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
35582984-7	2022	In terms of E2/SN2 competition, the barrier difference, , first increases then decreases as the number of explicit water molecules increases, under both microsolvation and bulk solvation conditions, but the inv-SN2 pathway is always favored over the anti-E2 pathway.	Water	115-120	solute carrier family 38 member 5	Homo sapiens	211-214
35477044-0	2022	A prospective study of myeloperoxidase levels in water immersion.	Water	49-54	myeloperoxidase	Homo sapiens	23-38
35477044-1	2022	INTRODUCTION: We aimed to compare myeloperoxidase levels in cord blood samples of mothers undergoing water immersion or conventional labor.	Water	101-106	myeloperoxidase	Homo sapiens	34-49
35477044-6	2022	The mean myeloperoxidase level was significantly lower in the water immersion group (759.8 +- 391.5 U/L) compared to that in the conventional labor group (1832.2 +- 1011.9 U/L, p = 0.004).	Water	62-67	myeloperoxidase	Homo sapiens	9-24
35477044-7	2022	DISCUSSION: Immersion in water during the first stage of labor seems to be associated with low myeloperoxidase levels, suggesting reduced oxidative stress in this delivery method.	Water	25-30	myeloperoxidase	Homo sapiens	95-110
35367942-7	2022	Additionally, ClO2 pre-oxidation reduced the genotoxicity (SOS/umu test) and cytotoxicity (Hep G2 cytotoxicity assay) of UV/chlorine-treated water by 26% and 20%, respectively.	Water	141-146	xylosyltransferase 2	Homo sapiens	59-62
35344716-10	2022	RESULTS: Water-soluble (PW) and ethyl acetate (PE) polar parts of DHZCP affected the HCC immune system by inhibiting the differentiation of Tregs, reversing the balance of Treg/Th1, and significantly reduced the tumor volume and weight.	Water	9-14	negative elongation factor complex member C/D, Th1l	Mus musculus	177-180
35149967-1	2022	Cystic fibrosis (CF) is due to a mutation in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which leads to unusual water and chloride secretion across epithelial surfaces.	Water	137-142	CF transmembrane conductance regulator	Homo sapiens	49-100
35149967-1	2022	Cystic fibrosis (CF) is due to a mutation in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which leads to unusual water and chloride secretion across epithelial surfaces.	Water	137-142	CF transmembrane conductance regulator	Homo sapiens	107-111
35325404-1	2022	BACKGROUND: Immunoglobulin A (IgA) nephropathy (IgAN) is one of an important cause of progressive kidney disease and occurs when IgA settles in the kidney resulted in disrupts kidney"s ability to filter waste and excess water.	Water	220-225	CD79a molecule	Homo sapiens	12-28
35325404-1	2022	BACKGROUND: Immunoglobulin A (IgA) nephropathy (IgAN) is one of an important cause of progressive kidney disease and occurs when IgA settles in the kidney resulted in disrupts kidney"s ability to filter waste and excess water.	Water	220-225	CD79a molecule	Homo sapiens	30-33
35325404-1	2022	BACKGROUND: Immunoglobulin A (IgA) nephropathy (IgAN) is one of an important cause of progressive kidney disease and occurs when IgA settles in the kidney resulted in disrupts kidney"s ability to filter waste and excess water.	Water	220-225	CD79a molecule	Homo sapiens	129-132
35583237-4	2022	Repeated washing of primary beta-/gamma-TiP with hydrochloric acid results in formation of a weakly ordered solid, TiO(OH)(H2PO4) H2O, TiP1-H.	Water	130-133	Tax1 binding protein 3	Homo sapiens	135-139
35561157-10	2022	Long-term trends in surface water NO3 - concentrations based on USGS surface water data showed downward trends after restoration at both the restored and control sites, whereas specific conductance showed no trend.	Water	28-33	NBL1, DAN family BMP antagonist	Homo sapiens	34-37
35561157-10	2022	Long-term trends in surface water NO3 - concentrations based on USGS surface water data showed downward trends after restoration at both the restored and control sites, whereas specific conductance showed no trend.	Water	77-82	NBL1, DAN family BMP antagonist	Homo sapiens	34-37
35614180-0	2022	Longer amplicons provide better sensitivity for electrochemical sensing of viral nucleic acid in water samples using PCB electrodes.	Water	97-102	pyruvate carboxylase	Homo sapiens	117-120
35624485-15	2022	Furthermore, the ROS/ TXNIP/ HIF-1alpha pathway was shown to mediate the therapeutic effect of melatonin in EAU.	Water	108-111	thioredoxin interacting protein	Mus musculus	22-27
35618264-4	2022	Forest wildfire affected ecosystems can also benefit from biosolids applications; application rates of up to 80 Mg ha-1 can lead to greater plant establishment, soil microbial activity, nutrient turnover, and reduced nutrient and heavy metal concentrations in runoff below livestock and US EPA drinking water standards.	Water	303-308	Rho GTPase activating protein 45	Homo sapiens	115-119
35611976-3	2022	For each sample, we determined the solubility and dissolution kinetics of 17 elements in a solution simulating fog water in the winter season in the Po Valley (pH 4.7, T 5  C, and water content ~0.5 g m-3).	Water	115-120	zinc finger protein, FOG family member 1	Homo sapiens	111-114
35531873-0	2022	Monitoring the water content in NADES extracts from spirulina biomass by means of ATR-IR spectroscopy.	Water	15-20	ATR serine/threonine kinase	Homo sapiens	82-85
35531873-1	2022	Attenuated total reflectance-infrared spectroscopy (ATR-IR) coupled with partial least squares regression (PLSR) was evaluated as a rapid, label free and cost-effective tool to quantify water content in extracts obtained from spirulina wet biomass using a glucose glycerol natural deep eutectic solvent (NADES).	Water	186-191	ATR serine/threonine kinase	Homo sapiens	52-55
35613378-0	2022	Myelin water imaging using a short-TR adiabatic inversion-recovery (STAIR) sequence.	Water	7-12	coagulation factor II thrombin receptor	Homo sapiens	35-37
35613378-1	2022	PURPOSE: To develop a new myelin water imaging (MWI) technique using a short-TR adiabatic inversion-recovery (STAIR) sequence on a clinical 3T MR scanner.	Water	33-38	coagulation factor II thrombin receptor	Homo sapiens	77-79
35613378-3	2022	A STAIR sequence with a short TR was designed to efficiently suppress long T1 signals from intracellular/extracellular water, and therefore allow selective imaging of MW, which has a much shorter T1 .	Water	119-124	coagulation factor II thrombin receptor	Homo sapiens	30-32
35623520-1	2022	Occurrence of profiles of the carbapenem-resistant Escherichia coli (CRE-E) and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (ESBL-E) in an urban river in a sub-catchment of the Yodo River Basin, one of the representative water systems of Japan was investigated.	Water	244-249	EsbL	Escherichia coli	80-112
35609523-5	2022	The effects of TRIM44 knockdown on inflammation, neurological function, and TLR4-NF-kappaB signaling in TBI rats were revealed by the detection of proinflammatory cytokines and TLR4-NF-kappaB signaling molecules, modified neurological severity score, brain water content, and Evans blue permeability.	Water	257-262	tripartite motif-containing 44	Rattus norvegicus	15-21
35609013-0	2022	Morphology Tuned Pt3 Ge Accelerates Water Dissociation to Industrial Standard Hydrogen Production over a wide pH Range.	Water	36-41	zinc finger protein 135	Homo sapiens	17-20
35609013-2	2022	We introduce a novel electrocatalyst, Pt3 Ge, engineered with a desired crystallographic facet (202) accelerates hydrogen production by water electrolysis and records industrially desired operational stability compared to the commercial catalyst platinum.	Water	136-141	zinc finger protein 135	Homo sapiens	38-41
35609523-5	2022	The effects of TRIM44 knockdown on inflammation, neurological function, and TLR4-NF-kappaB signaling in TBI rats were revealed by the detection of proinflammatory cytokines and TLR4-NF-kappaB signaling molecules, modified neurological severity score, brain water content, and Evans blue permeability.	Water	257-262	toll-like receptor 4	Rattus norvegicus	177-181
35590479-3	2022	Intensive thinning led to the lowest NO3 -N concentration in soil water at all depths (0-100 cm) and highest FRB at shallow depths (0-50 cm).	Water	66-71	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
35631996-7	2022	The water-soluble excipient (HP-beta-CD) effectively enhance the dissolution rate of BDP from composite particles.	Water	4-9	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	32-39
35625336-0	2022	Whole-Genome Characterisation of ESBL-Producing E. coli Isolated from Drinking Water and Dog Faeces from Rural Andean Households in Peru.	Water	79-84	EsbL	Escherichia coli	33-37
35625336-3	2022	We aimed to confirm the identity and antimicrobial resistance (AMR) profile of two ESBL isolates from dog faeces and drinking water of rural Andean households and determine serotype, phylogroup, sequence type (ST)/clonal complex (CC), pathogenicity, virulence genes, ESBL genes, and their plasmids.	Water	126-131	EsbL	Escherichia coli	83-87
35630742-6	2022	The insertion of H2O2, H2O, N2O, and CO2 had significant influence on the electrostatic potential (ESP), van der Waals (vdW) potential and chemical bonding of CL-20.	Water	23-26	epithelial membrane protein 1	Homo sapiens	159-164
35631269-2	2022	In this study, the ability to regulate the production of IL-8 of the water-soluble non-starch polysaccharide (WS-NSP) from taro corm (Tc-WS-NSP) extracted using a conventional (CE) or improved conventional (ICE) extraction method, of the probiotics Lactobacillus acidophilus, Bifidobacterium breve, and Bifidobacterium infantis, and their synbiotic mixtures were evaluated.	Water	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
35584119-2	2022	Our osmotic stress studies of the visual receptor rhodopsin have redefined the standard model of GPCR signaling by revealing the essential role of bulk water.	Water	152-157	rhodopsin	Homo sapiens	50-59
35584119-3	2022	We show results consistent with a large number of water molecules flooding the rhodopsin interior during activation to stabilize the effector binding conformation.	Water	50-55	rhodopsin	Homo sapiens	79-88
35523200-3	2022	We demonstrate by detailed fluorescence studies the ability of a water-dispersible composite of dMOR-2 with polyvinylpyrrolidone for real-time detection of Cu2+, Pb2+, and Hg2+ in aqueous media.	Water	65-70	screw	Drosophila melanogaster	96-102
35635857-0	2022	Performance evaluation of a European wide proficiency test on gross alpha/beta activity determination in drinking water.	Water	114-119	amyloid beta precursor protein	Homo sapiens	26-27
35635857-0	2022	Performance evaluation of a European wide proficiency test on gross alpha/beta activity determination in drinking water.	Water	114-119	amyloid beta precursor protein	Homo sapiens	68-78
35635857-1	2022	JRC-Geel organised a Europe-wide proficiency test on gross alpha/beta activity concentration measurements in water with 154 participants from the field of environmental radioactivity monitoring.	Water	109-114	amyloid beta precursor protein	Homo sapiens	59-69
35395356-7	2022	DOCK2 downregulation improved long-term neurological function, which was assessed by the Morris water-maze test.	Water	96-101	dedicator of cyto-kinesis 2	Mus musculus	0-5
35587736-6	2022	The HGs embody more than 70% water amenable for hosting insulin in the matrix.	Water	29-34	insulin	Homo sapiens	56-63
35588257-5	2022	Model results show an increase in radial water exchange due to a decrease in sap viscosity leading to increased sugar front speed and axial mass transport across a wide range of phloem conduit lengths.	Water	41-46	SH2 domain containing 1A	Homo sapiens	77-80
35581939-6	2022	This phenotype is caused by defects in water reabsorption that are the result of reduced Na-K-2Cl cotransporter 2 (NKCC2) levels in the kidney.	Water	39-44	solute carrier family 12, member 1	Mus musculus	89-113
35575940-1	2022	BACKGROUND: Plants use different mechanisms to transport the collected fog water.	Water	75-80	zinc finger protein, FOG family member 1	Homo sapiens	71-74
35575940-2	2022	Leaf traits of wheat play an important role in directing fog water through leaf rolling and leaf angle into the root zone, where it can be stored for consumption.	Water	61-66	zinc finger protein, FOG family member 1	Homo sapiens	57-60
35576931-4	2022	The PTFEMA-r-SBMA membrane exhibits exceptional permeability and selectivity to primary ions in water solutions.	Water	96-101	androgen receptor	Homo sapiens	13-17
35580255-4	2022	By overlapping the roughness ranges with previous studies on Au, the limitation of surface roughness (RMS = 1 nm) to observation of the odd-even effect using water as probing liquid was confirmed, but other probing liquid yielded different roughness-dependent behaviors, with more polar solvent showing more roughness-dependent behavior.	Water	158-163	odd-skipped related transcription factor 1	Homo sapiens	136-139
35512266-8	2022	Moreover, the two-electrode system with CoS-5 as the anode and Pt/C as the cathode requires only 1.56 V to attain 10 mA cm-2 in the overall water-splitting reaction.	Water	140-145	zinc finger protein 69	Homo sapiens	40-45
35581939-6	2022	This phenotype is caused by defects in water reabsorption that are the result of reduced Na-K-2Cl cotransporter 2 (NKCC2) levels in the kidney.	Water	39-44	solute carrier family 12, member 1	Mus musculus	115-120
35581939-8	2022	These findings provide novel insight into CDK12 being necessary for maintaining renal homeostasis by regulating NKCC2 transcription, which explains the critical water and electrolyte disturbance that occurs during the application of CDK12 inhibitors for cancer treatment.	Water	161-166	solute carrier family 12, member 1	Mus musculus	112-117
35570193-2	2022	Herein we report three heterobimetallic uranyl phosphonates, namely, ((UO2)3M(2-pmbH)4(H2O)4) 2H2O (MU, M = Co(II), CoU; Mn(II), MnU; Zn(II), ZnU; 2-pmbH3 = 2-(phosphonomethyl)benzoic acid).	Water	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
35499316-2	2022	However, Janus membranes have an inherent disadvantage in terms of aerodynamic efficiency in harvesting fog because of the clogged water bridges caused by the small pore size.	Water	131-136	zinc finger protein, FOG family member 1	Homo sapiens	104-107
35183854-4	2022	Wairakite compressed in water medium has a polymorphic transformation at T   300  C and P   0.4 GPa.	Water	24-29	glycophorin A (MNS blood group)	Homo sapiens	96-99
35549028-4	2022	The adsorption of insulin onto the different materials is characterized through the conformational changes with respect to its conformation in water and the interfacial regions, which are described by specific arrangements of polymer chains, water, insulin, and plasticizer molecules.	Water	143-148	insulin	Homo sapiens	18-25
35549028-4	2022	The adsorption of insulin onto the different materials is characterized through the conformational changes with respect to its conformation in water and the interfacial regions, which are described by specific arrangements of polymer chains, water, insulin, and plasticizer molecules.	Water	242-247	insulin	Homo sapiens	18-25
35499316-4	2022	For a clogged mesh with a small hole size, capillary water transport to the mesh back via the wettability gradient in the direction of fog flow helps harvest more fog by enhancing water drainage, similarly to the Janus membrane.	Water	53-58	zinc finger protein, FOG family member 1	Homo sapiens	135-138
35499316-4	2022	For a clogged mesh with a small hole size, capillary water transport to the mesh back via the wettability gradient in the direction of fog flow helps harvest more fog by enhancing water drainage, similarly to the Janus membrane.	Water	53-58	zinc finger protein, FOG family member 1	Homo sapiens	163-166
35499316-4	2022	For a clogged mesh with a small hole size, capillary water transport to the mesh back via the wettability gradient in the direction of fog flow helps harvest more fog by enhancing water drainage, similarly to the Janus membrane.	Water	180-185	zinc finger protein, FOG family member 1	Homo sapiens	135-138
35499316-4	2022	For a clogged mesh with a small hole size, capillary water transport to the mesh back via the wettability gradient in the direction of fog flow helps harvest more fog by enhancing water drainage, similarly to the Janus membrane.	Water	180-185	zinc finger protein, FOG family member 1	Homo sapiens	163-166
35499316-5	2022	The advantage of the capillary water transport extends to a clog-free mesh with larger hole sizes but more preferably to a Janus mesh with a superhydrophilic back, which presents the highest level of fog-harvesting yield because of the fast shedding frequency and short onset time.	Water	31-36	zinc finger protein, FOG family member 1	Homo sapiens	200-203
35499316-6	2022	In contrast, a Janus mesh with a superhydrophobic front, which also has a wettability gradient along the fog flow, produces a lower fog-harvesting performance, particularly at slow fog speeds, because of the dropwise deposition of large water drops that locally disturb fog flow around a protruding water surface.	Water	237-242	zinc finger protein, FOG family member 1	Homo sapiens	105-108
35499316-6	2022	In contrast, a Janus mesh with a superhydrophobic front, which also has a wettability gradient along the fog flow, produces a lower fog-harvesting performance, particularly at slow fog speeds, because of the dropwise deposition of large water drops that locally disturb fog flow around a protruding water surface.	Water	237-242	zinc finger protein, FOG family member 1	Homo sapiens	132-135
35499316-6	2022	In contrast, a Janus mesh with a superhydrophobic front, which also has a wettability gradient along the fog flow, produces a lower fog-harvesting performance, particularly at slow fog speeds, because of the dropwise deposition of large water drops that locally disturb fog flow around a protruding water surface.	Water	237-242	zinc finger protein, FOG family member 1	Homo sapiens	181-184
35499316-6	2022	In contrast, a Janus mesh with a superhydrophobic front, which also has a wettability gradient along the fog flow, produces a lower fog-harvesting performance, particularly at slow fog speeds, because of the dropwise deposition of large water drops that locally disturb fog flow around a protruding water surface.	Water	237-242	zinc finger protein, FOG family member 1	Homo sapiens	270-273
35499316-6	2022	In contrast, a Janus mesh with a superhydrophobic front, which also has a wettability gradient along the fog flow, produces a lower fog-harvesting performance, particularly at slow fog speeds, because of the dropwise deposition of large water drops that locally disturb fog flow around a protruding water surface.	Water	299-304	zinc finger protein, FOG family member 1	Homo sapiens	105-108
35499316-6	2022	In contrast, a Janus mesh with a superhydrophobic front, which also has a wettability gradient along the fog flow, produces a lower fog-harvesting performance, particularly at slow fog speeds, because of the dropwise deposition of large water drops that locally disturb fog flow around a protruding water surface.	Water	299-304	zinc finger protein, FOG family member 1	Homo sapiens	132-135
35499316-6	2022	In contrast, a Janus mesh with a superhydrophobic front, which also has a wettability gradient along the fog flow, produces a lower fog-harvesting performance, particularly at slow fog speeds, because of the dropwise deposition of large water drops that locally disturb fog flow around a protruding water surface.	Water	299-304	zinc finger protein, FOG family member 1	Homo sapiens	181-184
35499316-6	2022	In contrast, a Janus mesh with a superhydrophobic front, which also has a wettability gradient along the fog flow, produces a lower fog-harvesting performance, particularly at slow fog speeds, because of the dropwise deposition of large water drops that locally disturb fog flow around a protruding water surface.	Water	299-304	zinc finger protein, FOG family member 1	Homo sapiens	270-273
35236025-7	2022	This work illustrates the application value of SAC combined with activated persulfate and the low energy consumption of the LED light in the field of environment, which provides a new strategy for reducing the salinity and treatment cost of treated water.	Water	249-254	small integral membrane protein 10 like 2A	Homo sapiens	124-127
35629829-11	2022	In the process of filtration of tap water contaminated with phthalate, the presence of imprints in the membrane structure resulted in more than three times higher sorption values (3.09 micromol/g) than in the case of non-imprinted membranes (1.12 micromol/g).	Water	36-41	SEC14 like lipid binding 2	Homo sapiens	32-35
35467876-4	2022	The novelty is emblematic for water, with alpha1 = 1.54 instead of alpha (Kamlet-Taft) = 1.17.	Water	30-35	BCL2 related protein A1	Homo sapiens	42-48
35630064-7	2022	These reasons led to a particularly complicated diagnosis of ALS in a 66-year-old Caucasian female patient complaining of dyspnoea and coughing while drinking water.	Water	159-164	superoxide dismutase 1	Homo sapiens	61-64
35510373-7	2022	Hypersecretion of pro-inflammatory cytokines, mainly IL-6, and increased infiltration of CD4+ and CD8+ T cells were observed in ascites mice treated by OH2, compared with those treated by 5-fluorouracil or nonresponders.	Water	152-155	interleukin 6	Mus musculus	53-57
35510373-8	2022	Furthermore, the initial-stage blocking of the IL-6 pathway was able to considerably suppress antitumor immune responses driven by OH2.	Water	131-134	interleukin 6	Mus musculus	47-51
35510373-10	2022	CONCLUSIONS: OH2 could safely eliminate malignant ascites of colon cancer and convert the cold immune microenvironment by inducing a remarkably regional cytokine storm in ascites, mainly IL-6, in the early stage of antitumor immune responses beyond directed oncolytic virotherapy.	Water	13-16	interleukin 6	Mus musculus	187-191
35135006-7	2022	RESULTS: D-allulose and erythritol induced a significant release of CCK, GLP-1 and PYY compared to tap water (all PHolm < 0.0001, dz > 1).	Water	103-108	cholecystokinin	Homo sapiens	68-71
35135006-7	2022	RESULTS: D-allulose and erythritol induced a significant release of CCK, GLP-1 and PYY compared to tap water (all PHolm < 0.0001, dz > 1).	Water	103-108	SEC14 like lipid binding 2	Homo sapiens	99-102
35135006-9	2022	Erythritol significantly delayed gastric emptying, increased fullness and decreased prospective food consumption compared to tap water (PHolm = 0.0002, dz = -1.05, PHolm = 0.0190, dz = 0.69 and PHolm = 0.0442, dz = -0.62, respectively).	Water	129-134	SEC14 like lipid binding 2	Homo sapiens	125-128
35452245-2	2022	A tightly focused laser on graphene under water introduces an sp3-type chemical defect by photo-oxidation.	Water	42-47	Sp3 transcription factor	Homo sapiens	62-65
35571246-13	2022	TXNIP knockdown dramatically ameliorated the 7-day survival rate, cognitive decline, brain damage, neuronal apoptosis, and the brain water content, inhibited the activation of microglia, downregulated the NLRP3/caspase-1 signaling pathway, and reduced the oxidative stress and the neuroinflammatory cytokine levels at 24 h post-LPS injection.	Water	133-138	thioredoxin interacting protein	Mus musculus	0-5
35512380-4	2022	We show that the amphiphilic headgroup of PS20 is too hydrophobic to partition in the water phase, which drives the binding of PS20 to the amphiphilic drug-binding domain of P-gp and thereby causes the inhibition of the protein.	Water	86-91	ATP binding cassette subfamily B member 1	Homo sapiens	174-178
35602050-7	2022	In addition, water chemistry (especially NO3 --N and Cl-) contributed more to explaining community assembly (especially the composition) than geographic distance and land use in the dry season, while the bacterioplankton community (especially the bacterioplankton network) was more influenced by distance (especially the length of rivers and dendritic streams) and land use (especially forest regions) in the wet season.	Water	13-18	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
35085740-2	2022	High (HAP) and Low (LAP) alcohol preferring mice are replicate lines of mice selectively bred to prefer 10% (v/v) ethanol to water and water to ethanol respectively in a free access two-bottle choice scenario.	Water	125-130	eye lens aplasia	Mus musculus	20-23
35445232-3	2022	However, our in situ Raman results show that the onset transition pressure can be as low as 9.7 GPa when using the methanol-ethanol-water (MEW) mixture as the pressure-transmitting medium (PTM), indicated by an additional GD Raman peak caused by the sp3 bonding between adjacent graphite layers.	Water	132-137	Sp3 transcription factor	Homo sapiens	250-253
35414170-13	2022	The purpose of this Account is to provide an overview of the breadth of new research perspectives that emerged from the development of water-soluble fac-(Ir(ppy))3 complexes (ppy = 2-phenylpyridine) with sulfonated ligands.	Water	135-140	FA complementation group C	Homo sapiens	149-152
35435655-5	2022	In the first section we summarize how specific examples of (hetero)arylboronic acids can decompose via aqueous protodeboronation processes: Ar-B(OH)2 + H2O   ArH + B(OH)3.	Water	152-155	low density lipoprotein receptor adaptor protein 1	Homo sapiens	158-161
35266301-8	2022	Under these optimal conditions, the limits of detection and limits of quantitation determined were in the range of 0.5-2.8 mug L-1 and 1.5-9 mug L-1 , for water, urine and plasma samples, respectively.	Water	155-160	L1 cell adhesion molecule	Homo sapiens	127-140
35151821-2	2022	METHODS: Lysozyme/PHC mixtures with 1:1 and 1:3 (w/w) ratios are freeze-dried from either H2O or D2O solutions.	Water	90-93	lysozyme	Homo sapiens	9-17
35196505-12	2022	Significant suppression of EAU was seen with alpha-MSH or PL8331 treatment.	Water	27-30	STAM binding protein	Mus musculus	45-54
35196505-17	2022	Our previous studies show the melanocortin system"s importance in maintaining ocular immune privilege and that alpha-MSH-treatment accelerates recovery and induces retinal-antigen-specific regulatory immunity in EAU.	Water	212-215	STAM binding protein	Mus musculus	111-120
35323077-7	2022	RESULTS: Relative to thermoneutral water immersion, hot water immersion increased core temperature (+1.66 C (+1.47, +1.87), P<0.01), heart rate (+34 bpm (+24, +44), P<0.01), antegrade shear rate (+96 s-1 (+57, +134), P<0.01), and IL-6 (+1.38 pg/mL (+0.31, +2.45), P=0.01).	Water	56-61	interleukin 6	Homo sapiens	230-234
35414397-5	2022	Based on the principle, in the presence of thrombin, the water of the plasma solution cannot flow along with the test paper as the water molecules are trapped in the fibrin.	Water	57-62	coagulation factor II, thrombin	Homo sapiens	43-51
35414397-5	2022	Based on the principle, in the presence of thrombin, the water of the plasma solution cannot flow along with the test paper as the water molecules are trapped in the fibrin.	Water	131-136	coagulation factor II, thrombin	Homo sapiens	43-51
35414397-6	2022	Upon the inactivation of thrombin by the inhibitors, water can flow along the test paper.	Water	53-58	coagulation factor II, thrombin	Homo sapiens	25-33
35063548-0	2022	Surface migration of Pb(II) from water and soil using an aerogel/graphite felt primary cell system.	Water	33-38	submaxillary gland androgen regulated protein 3B	Homo sapiens	21-27
35063548-1	2022	To develop a zero energy consumption electrokinetic remediation method of Pb(II) in water and soil, a primary cell system was constructed via synergistic effects of the electromigration, ion exchange, precipitation and hydrogen bond.	Water	84-89	submaxillary gland androgen regulated protein 3B	Homo sapiens	74-80
35354245-3	2022	In the proximal tubule (PT), claudin-2 forms paracellular channels selective for water, Na+ , K+ , and Ca2+.	Water	81-86	claudin 2	Homo sapiens	29-38
35488182-13	2022	These findings suggest that the EAU risk groups could be improved with the addition of PSMA PET.	Water	32-35	folate hydrolase 1	Homo sapiens	87-91
35302684-3	2022	Rhodopsin (RH1) is the only opsin responsible for dim-light vision in vertebrates and has been shown to evolve in response to the respective light conditions, including along a water depth gradient in fishes.	Water	177-182	rhodopsin	Homo sapiens	0-9
35491241-3	2022	Herein, the design and synthesis of an sp2 -carbon conjugated COF (sp2 -TPE-COF) are reported with surfactant-assisted water dispersion for detecting traces of copper ions based on the photo-induced electron transfer (PET) mechanism.	Water	119-124	Sp2 transcription factor	Homo sapiens	39-42
35084714-8	2022	In addition, an increased expression of water and ion channels, including AQP3, CFTR, ENaCA, and CRISP2 was also observed which could also be inhibited by ETA.	Water	40-45	CF transmembrane conductance regulator	Homo sapiens	80-84
35084714-8	2022	In addition, an increased expression of water and ion channels, including AQP3, CFTR, ENaCA, and CRISP2 was also observed which could also be inhibited by ETA.	Water	40-45	sodium channel epithelial 1 subunit alpha	Homo sapiens	86-91
35566207-3	2022	The appended beta-CD units in OFP-CD enabled the forming of host-guest complexes with dabsyl chloride moieties in water, resulting in fluorescence quenching of the oligofluorene through intermolecular energy transfer.	Water	114-119	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	13-20
35436087-3	2022	We report here a water-soluble Pd(II) molecular boat (MB1) with unusual structural topology that was obtained by assembling a flexible tetrapyridyl donor (L) with a cis-Pd(II) acceptor.	Water	17-22	CD79a molecule	Homo sapiens	54-57
35602962-4	2022	Similarly, higher carbon fixation potential of AOA, evaluated by the ratios of amoA to accA gene, was also observed below euphotic zone and the ratios increased with increasing water depth.	Water	177-182	G protein-coupled receptor 3	Homo sapiens	87-91
35439020-4	2022	The box with NO3-   water wires confers high proton conductivity and presents the first example that manifests redox and ionic functionality in an organic electron-deficient macrocycle.	Water	20-25	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
35574007-0	2022	Gender- and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Based Water-Fat MRI.	Water	174-179	renin binding protein	Homo sapiens	12-15
35416654-7	2022	With a suitably tuned oxidant strength, we found an ET-limited reaction at pH < 4 and weakly pH-dependent rates at pH > ~5 that are intrinsic to the PCET of the indole group with water (H2O) as the proton acceptor.	Water	179-184	major facilitator superfamily domain containing 11	Homo sapiens	52-54
35416654-7	2022	With a suitably tuned oxidant strength, we found an ET-limited reaction at pH < 4 and weakly pH-dependent rates at pH > ~5 that are intrinsic to the PCET of the indole group with water (H2O) as the proton acceptor.	Water	186-189	major facilitator superfamily domain containing 11	Homo sapiens	52-54
35470441-8	2022	Water-exposed females drinking ethanol showed more social investigation as well as significantly higher hypothalamic OXTR, AVP, and AVPR1b gene expression than their counterparts ingesting supersac and AIE females drinking ethanol.	Water	0-5	arginine vasopressin	Rattus norvegicus	123-126
35590930-2	2022	In this work, a hybrid model (dubbed MR-CART) is proposed, based on a combination of MR (multiple regression) and CART (classification and regression tree) machine-learning methods, applied to an IARR predicted data series obtained from a set of non-parametric and empirical water balance models in five climatic floors of northern Algeria between 1960 and 2020.	Water	275-280	CART prepropeptide	Homo sapiens	40-44
35460327-6	2022	The developed method was successfully applied for the determination of 20 beta-blockers and eight beta2-agonists in river water, human urine, and freeze-dried pork liver powder.	Water	122-127	ATPase H+ transporting V0 subunit a2	Homo sapiens	98-103
35566085-5	2022	Methods: In this study, a novel water-soluble 3H-indocyanine-type bioluminescent dye-Cy5-labeled prostate-specific membrane antigen (PSMA) ligand (PSMA-Cy5) was synthesized by liquid phase synthesis.	Water	32-37	folate hydrolase 1	Homo sapiens	147-151
35590930-2	2022	In this work, a hybrid model (dubbed MR-CART) is proposed, based on a combination of MR (multiple regression) and CART (classification and regression tree) machine-learning methods, applied to an IARR predicted data series obtained from a set of non-parametric and empirical water balance models in five climatic floors of northern Algeria between 1960 and 2020.	Water	275-280	CART prepropeptide	Homo sapiens	114-118
35591378-6	2022	Two phase transitions were identified in water confined within 2 nm wide slit-shaped nanopores: (1) at p1 = 3.3-3.4 GPa, the liquid transforms to a solid phase with a hexagonal close-packed (HCP) crystal structure, and (2) at p2 = 6.7-7.1 GPa, a further transformation to face-centered cubic (FCC) crystals occurs.	Water	41-46	glycophorin A (MNS blood group)	Homo sapiens	116-119
35624684-6	2022	Despite the lesser glutathione response in cotton, hydrogen peroxide levels were low in water-stressed cotton compared with maize roots and were associated with higher catalase, ascorbate peroxidase, and superoxide dismutase activities in cotton.	Water	88-93	peroxidase 1	Zea mays	188-198
35522490-1	2022	Structural transformation of hot dense water ice is investigated by combining synchrotron x-ray diffraction and a laser-heating diamond anvil cell above 25 GPa.	Water	39-44	glycophorin A (MNS blood group)	Homo sapiens	156-159
35591378-6	2022	Two phase transitions were identified in water confined within 2 nm wide slit-shaped nanopores: (1) at p1 = 3.3-3.4 GPa, the liquid transforms to a solid phase with a hexagonal close-packed (HCP) crystal structure, and (2) at p2 = 6.7-7.1 GPa, a further transformation to face-centered cubic (FCC) crystals occurs.	Water	41-46	glycophorin A (MNS blood group)	Homo sapiens	239-242
35591378-8	2022	In this case, water transforms directly from the liquid phase to an FCC-like phase at 3.2-3.3 GPa.	Water	14-19	glycophorin A (MNS blood group)	Homo sapiens	94-97
35514354-2	2022	We provided evidence that high calcium delivery to the collecting duct reduces local Aquaporin 2 (AQP2)-mediated water reabsorption under vasopressin action, thus limiting the maximal urinary concentration to reduce calcium saturation.	Water	113-118	arginine vasopressin	Homo sapiens	138-149
35411772-2	2022	The Lorentz-Berthelot combining rules were adopted for the unlike-pair interactions of Na+, Cl-, and the oxygen site in SPC/E water, and geometric combining rules were utilized for the remainder of the cross interactions.	Water	126-131	surfactant protein C	Homo sapiens	120-123
35518645-1	2022	Aquaporin-4 (AQP4) is the predominant water channel in the brain; it is enriched in astrocytic foot processes abutting vessels where it is anchored through an interaction with the dystrophin-associated protein (DAP) complex.	Water	38-43	death-associated protein	Mus musculus	180-209
35514354-4	2022	We report here that 10 days of inactivity are associated with a transient, significant decrease (day 5) in vasopressin (copeptin) paralleled by a decrease in AQP2 excretion, consistent with an increased central volume to the heart, resulting in reduced water reabsorption.	Water	253-258	arginine vasopressin	Homo sapiens	107-118
35518645-1	2022	Aquaporin-4 (AQP4) is the predominant water channel in the brain; it is enriched in astrocytic foot processes abutting vessels where it is anchored through an interaction with the dystrophin-associated protein (DAP) complex.	Water	38-43	death-associated protein	Mus musculus	211-214
35514354-4	2022	We report here that 10 days of inactivity are associated with a transient, significant decrease (day 5) in vasopressin (copeptin) paralleled by a decrease in AQP2 excretion, consistent with an increased central volume to the heart, resulting in reduced water reabsorption.	Water	253-258	arginine vasopressin	Homo sapiens	120-128
35514996-4	2022	A combination of oral AHCC  and dual immune checkpoint blockade (DICB), including PD-1/CTLA-4 blockade, had reduced tumor growth and increased granzyme B and Ki-67 expression by tumor-infiltrating CD8+ T cells in MC38 colon cancer bearing mice compared to a combination of water and DICB.	Water	273-278	programmed cell death 1	Mus musculus	82-86
35457188-6	2022	Our results indicated that 27-OHC-treated mice showed worse learning and memory ability and higher immune responses, but lower expression level of interleukin-10 (IL-10) and interferon (IFN-lambda2) compared with saline-treated mice, while 24S-OHC mice performed better in the Morris water maze test than control mice.	Water	284-289	interleukin 10	Mus musculus	147-161
35384955-3	2022	The limiting stage is the stage of cyclization involving the intramolecular attack by the amino group of the precyclic intermediate on the carbon atom bound to the hydroxyl group with the simultaneous release of a water molecule according to the SN2 mechanism.	Water	214-219	solute carrier family 38 member 5	Homo sapiens	246-249
35447164-7	2022	For instance, central infusion of IL-1beta or TNF-alpha can directly affect sodium and water consumption in animal models.	Water	87-92	tumor necrosis factor	Homo sapiens	46-55
35437791-4	2022	In this study, the human esophageal epithelial cells (Het-1A) were used to explore potential mechanisms of the activation of NLRP3 inflammasome under co-exposure to nine nitrosamines commonly found in drinking water at the doses of 0, 4, 20, 100, 500 and 2500 ng/mL.	Water	210-215	NLR family pyrin domain containing 3	Homo sapiens	125-130
35457188-6	2022	Our results indicated that 27-OHC-treated mice showed worse learning and memory ability and higher immune responses, but lower expression level of interleukin-10 (IL-10) and interferon (IFN-lambda2) compared with saline-treated mice, while 24S-OHC mice performed better in the Morris water maze test than control mice.	Water	284-289	interferon lambda 2	Mus musculus	186-197
35497774-2	2022	The present work aimed to encapsulate iron in a water-in-oil-in-water double emulsion (W1/O/W2), which was formed with whey protein isolate and polyglycerol polyricinoleate as the emulsifying agents, tara gum as a thickening agent, and sucrose as an osmotic active substance.	Water	48-53	TRIO and F-actin binding protein	Homo sapiens	200-204
35007575-13	2022	In the alluvial aquifer, the transfer of NO3- is limited both physically (through groundwater-surface water disconnection) and chemically (through denitrification).	Water	102-107	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
35421131-7	2022	The water mist is fragmented into smaller fog droplets under the action of rotating airflow, which improves the dust catching effect of the fog curtain.	Water	4-9	zinc finger protein, FOG family member 1	Homo sapiens	42-45
35421131-7	2022	The water mist is fragmented into smaller fog droplets under the action of rotating airflow, which improves the dust catching effect of the fog curtain.	Water	4-9	zinc finger protein, FOG family member 1	Homo sapiens	140-143
35312312-6	2022	In the absence of water, the low-frequency vibrations of CaM are stiffened by ligand binding.	Water	18-23	calmodulin 1	Homo sapiens	57-60
35458686-4	2022	Abeta peptides tend to exist at hydrophilic/hydrophobic interfaces and form more beta-hairpin structures than in bulk water.	Water	118-123	amyloid beta precursor protein	Homo sapiens	0-5
35547777-3	2022	Methods: C11G3-TBP dendrons were synthesized via divergent synthesis and self-assembled to generate nanomicelles in a water environment to load hydrophobic drug Cur.	Water	118-123	TATA box binding protein	Mus musculus	15-18
35358381-7	2022	Further, the investigation of the ORR activity of Co(10-DMIC) using a combination of electrochemical and chemical reduction studies revealed that this simple, unadorned monomeric Co(II) tetrapyrrole is ~85% selective for the 4e-/4H+ reduction of O2 to H2O over the more kinetically facile 2e-/2H+ process that delivers H2O2.	Water	252-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
35456840-7	2022	Along the salinity gradient, OTU1 abundance increased with decreasing water temperatures and increasing rainfalls, and it showed a maximum in January; OTU2 increased with increasing BOD5 and it showed the highest abundances in the period August-October, and OTU 3194 increased at decreasing salinities.	Water	70-75	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	29-33
35393843-7	2022	Compared with those under fresh water irrigation, soil sucrase, alkaline phosphatase, and catalase activities under saline water irrigation decreased by 57.24%, 35.15%, and 3.91%, respectively, whereas urease activity increased by 26.73%.	Water	123-128	catalase	Homo sapiens	90-98
35403324-6	2022	Specifically, the regulatory function of ATF4 and demethylase JMJD3 on the ischemic injury was explored via using ectopic expression and depletion by determination of modified neurologic severity score, blood-brain barrier, brain water content, apoptosis, infarct size, oxidative stress, and inflammation.	Water	230-235	activating transcription factor 4	Rattus norvegicus	41-45
35081773-1	2022	Attenuated total reflection-far-ultraviolet (ATR-FUV) spectra in the 145 - 250 nm region were studied for four kinds of proteins (two alpha-helix rich proteins; bovine serum albumin (BSA) and lysozyme, and two beta-sheet rich proteins; concanavalin A and gamma-globulin) in different solutions (pure water and phosphate buffered saline (PBS)) with different concentrations.	Water	300-305	ATR serine/threonine kinase	Homo sapiens	45-48
35393820-3	2022	In terms of the detection rate and concentration of each monomer PAEs, DiBP, DBP, and DEHP were the main PAEs components in the water body.	Water	128-133	D-box binding PAR bZIP transcription factor	Homo sapiens	77-80
35454420-5	2022	The absorption capacity of I-SAP in the synthetic pore solution and deionised water was examined and compared with that of a conventional SAP, and the former was absorbed more by I-SAP.	Water	78-83	SH2 domain containing 1A	Homo sapiens	27-32
35464209-0	2022	First-Principles Calculations of Two-Dimensional CdO/HfS2 Van der Waals Heterostructure: Direct Z-Scheme Photocatalytic Water Splitting.	Water	120-125	cell adhesion associated, oncogene regulated	Homo sapiens	49-52
35464209-4	2022	Importantly, the CdO/HfS2 vdW heterostructure possesses an intrinsic Z-scheme photocatalytic characteristic for water splitting by obtaining decent band edge positions.	Water	112-117	cell adhesion associated, oncogene regulated	Homo sapiens	17-20
35464209-6	2022	The CdO/HfS2 vdW heterostructure also has excellent optical absorption capacity, showing a promising role as a photocatalyst to decompose the water.	Water	142-147	cell adhesion associated, oncogene regulated	Homo sapiens	4-7
35454420-7	2022	Although the compressive strength of hydrated cement paste with I-SAP reduced in water or sealed curing conditions, no loss of strength in the paste cured at 60% RH was seen.	Water	81-86	SH2 domain containing 1A	Homo sapiens	64-69
35424977-1	2022	Among the cyclodextrins screened for the synthesis of 2-hydroxy-1,2-diphenylethanone (benzoin) in water, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) exhibited the highest yield in the benzoin condensation reactions, and HP-beta-CD can be recycled several times with little loss of activity through the addition of fresh VB1.	Water	98-103	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	143-150
35407333-1	2022	A pyrazole derivative (CB1) was previously evaluated in vivo for various pharmacological activities (with the exception of antimicrobial effects), using DMSO as the administrative medium, mainly due to its water insolubility.	Water	206-211	cannabinoid receptor 1	Homo sapiens	23-26
35407333-2	2022	Considering the global necessity for new antimicrobial agents, CB1 attracted our attention as a candidate to meet this need, mainly because the secondary amine group in its structure would make it possible to obtain its hydrochloride salt (CB1H), thus effortlessly solving its water-solubility drawbacks.	Water	277-282	cannabinoid receptor 1	Homo sapiens	63-66
35444557-0	2022	Metformin Inhibits Na+/H+ Exchanger NHE3 Resulting in Intestinal Water Loss.	Water	65-70	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	36-40
35444557-7	2022	We found that metformin decreased intestinal water absorption mediated by NHE3.	Water	45-50	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	74-78
35442497-0	2022	Randomized, double-blind, crossover, placebo-controlled clinical trial to evaluate the effects of chicken hot water extract on insulin secretion.	Water	110-115	insulin	Gallus gallus	127-134
35182949-8	2022	The Evans Blue leakage and brain water content were obviously reduced (P < 0.05) in vasoactive intestinal peptide-treated rats compared with those of control rats at 72 and 96 h after stroke.	Water	33-38	vasoactive intestinal peptide	Rattus norvegicus	84-113
35425690-1	2022	The self-assembly of the tobacco mosaic virus coat protein is significantly altered in alcohol-water mixtures.	Water	95-100	golgi phosphoprotein 3	Homo sapiens	46-58
35337572-2	2022	The length of broccoli sprouts and bulk water content were decreased after LED light treatments, especially white, green, and purple LED lights.	Water	40-45	small integral membrane protein 10 like 2A	Homo sapiens	75-78
35337572-2	2022	The length of broccoli sprouts and bulk water content were decreased after LED light treatments, especially white, green, and purple LED lights.	Water	40-45	small integral membrane protein 10 like 2A	Homo sapiens	133-136
35174545-6	2022	Interestingly, melatonin-alleviated symptoms of leaf senescence and starch degradation were compromised when the first key gene for starch degradation, alpha-glucan water dikinase (GWD), was overexpressed.	Water	165-170	glucan water dikinase	Solanum lycopersicum	181-184
35482377-4	2022	A total of 21 water samples were contaminated with E. coli and 15 isolates were identified as ESBL producers harboring blaTEM (40%) and blaCTX-M (33.33%) genes.	Water	14-19	EsbL	Escherichia coli	94-98
35482377-7	2022	The recovery of ESBL E. coli isolates resistant to higher generation Cephalosporins, Monobactam, and Carbapenems from water samples indicated an alarming situation.	Water	118-123	EsbL	Escherichia coli	16-20
35063424-3	2022	A notable exception are LHA neurons expressing neurotensin (LHANts neurons): activating these neurons promotes water intake but modestly restrains feeding.	Water	111-116	neurotensin	Homo sapiens	47-58
35311602-1	2022	AIM: To prepare ecdysterone(ES)/hydroxypropyl-beta-cyclodextrin(HP-beta-CD) inclusion complex, thus improving the water solubility and bioavailability of ES.	Water	114-119	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	67-74
35193743-1	2022	Sap flow, the transport of fluid in the water-conducting xylem tissues of plants, is commonly measured in studies of plant-water relationships by the heat pulse velocity method.	Water	40-45	SH2 domain containing 1A	Homo sapiens	0-3
35193743-1	2022	Sap flow, the transport of fluid in the water-conducting xylem tissues of plants, is commonly measured in studies of plant-water relationships by the heat pulse velocity method.	Water	123-128	SH2 domain containing 1A	Homo sapiens	0-3
35367247-8	2022	Altogether, the LT-HP-beta-CD represents a potential carrier for enhancing the water solubility and oral bioavailability of LT coupled with antitumor activity enhancement.	Water	79-84	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	22-29
35453560-0	2022	Oxidative Stress-Induced Alterations of Cellular Localization and Expression of Aquaporin 1 Lead to Defected Water Transport upon Peritoneal Fibrosis.	Water	109-114	aquaporin 1 (Colton blood group)	Homo sapiens	80-91
35408665-5	2022	This Achilles" heel prompted us to implement a new strategy to obtain a series of dyes that retain all the photophysical features of dEAF in water, conjugate readily with oligonucleotides, and furthermore demonstrate sensitivity to hydration, thus paving the way for a high-performance fluorogenic DNA hybridization probe.	Water	141-146	ELL-associated factor	Drosophila melanogaster	133-137
35453560-6	2022	Functional interference of aquaporin 1 on free water transport would result in PD failure in patients.	Water	47-52	aquaporin 1 (Colton blood group)	Homo sapiens	27-38
35347618-5	2022	In the river water and leaf litter leachate, the abundant humic-like components were quenched by 6-17% while the protein-like component kept stable (2-4%) by the addition of Pb(II).	Water	13-18	submaxillary gland androgen regulated protein 3B	Homo sapiens	174-180
35340071-1	2022	BACKGROUND: Vasopressin concentration is typically higher at night, during stress, and in males, but readily lowered by water intake.	Water	120-125	arginine vasopressin	Homo sapiens	12-23
35408623-3	2022	1H NMR spin-lattice relaxation experiments were performed for the collection of products in a broad frequency range from 4 KHz to 30 MHz to get insight into the influence of different sugar types and SPI on the dynamics of water in composite gel systems.	Water	223-228	chromogranin A	Homo sapiens	200-203
35408623-6	2022	The influence of the sample composition (the type of sugar and/or the presence of SPI) on the water mobility was thoroughly discussed.	Water	94-99	chromogranin A	Homo sapiens	82-85
35401584-3	2022	Tree water use was assessed via radial patterns of sap flow in eight dominant canopy trees, each a different species with a range in diameter, height, and wood density.	Water	5-10	SH2 domain containing 1A	Homo sapiens	51-54
35364374-3	2022	The NO3- concentration supplied by the fish water was 47% of the control solution.	Water	44-49	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
35401584-9	2022	Stand level water use, based on multiple plots encompassing sap flow and adjacent trees, varied from ~1.7 to 3.3 mm per day, increasing linearly with plot basal area.	Water	12-17	SH2 domain containing 1A	Homo sapiens	60-63
35275642-1	2022	Using time-resolved wide-angle X-ray scattering, we investigated the early stages (10 mus-1 ms) of crystallization of supercooled water, obtained by the ultrafast heating of high- and low-density amorphous ice (HDA and LDA) up to a temperature T = 205 K +- 10 K. We have determined that the crystallizing phase is stacking disordered ice (Isd), with a maximum cubicity of chi = 0.6, in agreement with predictions from molecular dynamics simulations at similar temperatures.	Water	130-135	carboxylesterase 2	Homo sapiens	206-209
35275642-1	2022	Using time-resolved wide-angle X-ray scattering, we investigated the early stages (10 mus-1 ms) of crystallization of supercooled water, obtained by the ultrafast heating of high- and low-density amorphous ice (HDA and LDA) up to a temperature T = 205 K +- 10 K. We have determined that the crystallizing phase is stacking disordered ice (Isd), with a maximum cubicity of chi = 0.6, in agreement with predictions from molecular dynamics simulations at similar temperatures.	Water	130-135	carboxylesterase 2	Homo sapiens	334-337
35407694-9	2022	It is shown that the work of adhesion of water to lime is 28.9 erg/cm2, and that of the sol is 32.8 erg/cm2.	Water	41-46	ETS transcription factor ERG	Homo sapiens	63-66
35332243-5	2022	These AR events are playing prominent role in enhancing water vapor over IGP region by 19 +- 5%; in turn fueling the intensification of fog and haze through aerosol-water vapor interaction.	Water	56-61	zinc finger protein, FOG family member 1	Homo sapiens	136-139
35332243-5	2022	These AR events are playing prominent role in enhancing water vapor over IGP region by 19 +- 5%; in turn fueling the intensification of fog and haze through aerosol-water vapor interaction.	Water	165-170	zinc finger protein, FOG family member 1	Homo sapiens	136-139
35274635-8	2022	The method is here applied to six SN2 reactions in water at 295.15 K, which differ in the nucleophile and the leaving group.	Water	51-56	solute carrier family 38 member 5	Homo sapiens	34-37
35327814-0	2022	Copeptin Concentrations in Plasma of Healthy Neonates in Relation to Water-Electrolyte Homeostasis in the Early Adaptation Period.	Water	69-74	arginine vasopressin	Homo sapiens	0-8
35411221-8	2022	Given the increased water-solubility, hydrogen bonds were found on Ala262 and Ile347 residues in the docked complex of derivative (HD2) to produce more steady interaction and initiate signaling pathways that were not observed in the case of heliomycin.	Water	20-25	histone deacetylase 2	Homo sapiens	131-134
35304555-1	2022	Shortages of freshwater have become increasingly common around the world, and various studies have been conducted to solve this problem by collecting and reusing the water in nature or from factories and power plants that produce large fog plumes.	Water	166-171	zinc finger protein, FOG family member 1	Homo sapiens	236-239
35304555-7	2022	Finally, to reduce loss during the draining of collected water droplets, the discharge direction of the fog flow was changed to follow the same direction as fog-laden flows in nature.	Water	57-62	zinc finger protein, FOG family member 1	Homo sapiens	104-107
35304555-7	2022	Finally, to reduce loss during the draining of collected water droplets, the discharge direction of the fog flow was changed to follow the same direction as fog-laden flows in nature.	Water	57-62	zinc finger protein, FOG family member 1	Homo sapiens	157-160
35370790-3	2022	Neurosecretory magnocellular neurons (MCNs) of the PVN are the main source of the hormones vasopressin (VP), responsible for water conservation and hydromineral balance, and oxytocin (OT), involved in parturition and milk ejection during lactation.	Water	125-130	arginine vasopressin	Homo sapiens	91-102
35382326-0	2022	A Novel Coordination Polymer as Adsorbent Used to Remove Hg(II) and Pb(II) from Water with Different Adsorption Mechanisms.	Water	80-85	submaxillary gland androgen regulated protein 3B	Homo sapiens	68-74
35411221-10	2022	Taken together, these findings clearly show that SIRT1 is targeted and downregulated by heliomycin and its water-soluble 4-aminomethylated derivative (HD2) possibly through autophagic and/or proteasomal degradation, leading to cell death and growth suppression of T24 bladder cancer cells.	Water	107-112	histone deacetylase 2	Homo sapiens	151-154
35371288-2	2022	Methods: The novel p-HLP was isolated from Bachu mushroom through hot water extraction, ethanol precipitation, and column chromatography.	Water	70-75	cysteine rich protein 2	Mus musculus	21-24
35219956-1	2022	Benzophenone-3 (BP-3) is widely used in a variety of cosmetics and is prevalent in drinking water or food, and women were under notable high exposure burden of BP-3.	Water	92-97	BP3	Homo sapiens	16-20
35234225-0	2022	A tetra Co(II/III) complex with an open cubane Co4O4 core and square-pyramidal Co(II) and octahedral Co(III) centres: bifunctional electrocatalytic activity towards water splitting at neutral pH.	Water	165-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
35234225-0	2022	A tetra Co(II/III) complex with an open cubane Co4O4 core and square-pyramidal Co(II) and octahedral Co(III) centres: bifunctional electrocatalytic activity towards water splitting at neutral pH.	Water	165-170	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	101-108
35291774-0	2022	Insulin aspart dimer dissociation in water.	Water	37-42	insulin	Homo sapiens	0-7
35329028-4	2022	beta-HCH levels were positively related to age, body mass index (BMI), mother"s occupation in agriculture during pregnancy, living in Poniente and Alpujarras, white fish, milk and water consumption, and negatively related to being male, living near to an agricultural area, working >=10 years in agriculture, and beer consumption.	Water	180-185	nuclear receptor subfamily 0 group B member 1	Homo sapiens	0-8
35291774-8	2022	Additionally, water plays a vital role in the dissociation of the insulin aspart by stabilizing the monomers in the dissociated state.	Water	14-19	insulin	Homo sapiens	66-73
35336811-2	2022	These mechanisms include synthesis of auxins, especially indoleacetic acid, which directly promotes plant growth; synthesis of antioxidant enzymes such as catalase, superoxide dismutase and peroxidase, which prevents the deleterious effects of reactive oxygen species; synthesis of small molecule osmolytes, e.g., trehalose and proline, which structures the water content within plant and bacterial cells and reduces plant turgor pressure; nitrogen fixation, which directly improves plant growth; synthesis of exopolysaccharides, which protects plant cells from water loss and stabilizes soil aggregates; synthesis of antibiotics, which protects stress-debilitated plants from soil pathogens; and synthesis of the enzyme 1-aminocyclopropane-1-carboxylate (ACC) deaminase, which lowers the level of ACC and ethylene in plants, thereby decreasing stress-induced plant senescence.	Water	358-363	catalase	Homo sapiens	155-163
35336811-2	2022	These mechanisms include synthesis of auxins, especially indoleacetic acid, which directly promotes plant growth; synthesis of antioxidant enzymes such as catalase, superoxide dismutase and peroxidase, which prevents the deleterious effects of reactive oxygen species; synthesis of small molecule osmolytes, e.g., trehalose and proline, which structures the water content within plant and bacterial cells and reduces plant turgor pressure; nitrogen fixation, which directly improves plant growth; synthesis of exopolysaccharides, which protects plant cells from water loss and stabilizes soil aggregates; synthesis of antibiotics, which protects stress-debilitated plants from soil pathogens; and synthesis of the enzyme 1-aminocyclopropane-1-carboxylate (ACC) deaminase, which lowers the level of ACC and ethylene in plants, thereby decreasing stress-induced plant senescence.	Water	562-567	catalase	Homo sapiens	155-163
35359364-3	2022	By conjugating heavy water (D2O) probed Raman scattering with label-free two-photon fluorescence (TPF) microscopy, we observed altered de novo lipogenesis, 3D lipid droplet morphology, and lipid peroxidation under various methionine and insulin concentrations.	Water	21-26	insulin	Homo sapiens	237-244
35213168-7	2022	The Raman and ATR-FTIR spectral analysis suggest a variation in the microstructure of the water/oil interface due to the differential interaction of the counterions with AOT headgroups and water.	Water	90-95	ATR serine/threonine kinase	Homo sapiens	14-17
35195417-4	2022	Compound 15 bearing a -CF2H motif emerged as a water-soluble, orally bioavailable CNS-permeant potent inhibitor of both human AChE (IC50 = 550 nM) and MAO B (IC50 = 8.2 nM, B/A selectivity > 1200).	Water	47-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-130
35424765-0	2022	Facile preparation of fluorescent water-soluble non-conjugated polymer dots and fabricating an acetylcholinesterase biosensor.	Water	34-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-115
35309493-1	2022	Water shortages have become a serious issue, so the importance of developing innovative cellulose-based superabsorbent polymer (SAP) was experimentally assessed as an environmentally friendly alternative to acrylate-based SAPs for the optimization of water consumption.	Water	0-5	SH2 domain containing 1A	Homo sapiens	128-131
35213680-0	2022	Dielectric relaxations of ice and uncrystallized water in partially crystallized bovine serum albumin-water mixtures.	Water	102-107	albumin	Homo sapiens	88-101
35617891-2	2022	In this study, we explored the possibility of using prokaryotic water-soluble cytochrome P450 (CYP) to produce human metabolites.	Water	64-69	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	78-93
35617891-2	2022	In this study, we explored the possibility of using prokaryotic water-soluble cytochrome P450 (CYP) to produce human metabolites.	Water	64-69	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	95-98
35309493-1	2022	Water shortages have become a serious issue, so the importance of developing innovative cellulose-based superabsorbent polymer (SAP) was experimentally assessed as an environmentally friendly alternative to acrylate-based SAPs for the optimization of water consumption.	Water	251-256	SH2 domain containing 1A	Homo sapiens	128-131
35309493-4	2022	In distilled water (d-water), the equilibrium water absorption capacity (EW) of the synthesized composite hydrogels (SAP-IPN1) is 1200 g (d-water/1g hydrogel) which is superior to any other commercial polyacrylate SAP hydrogels, while in saline water the EW is 650 g (s-water/1g hydrogel).	Water	46-51	SH2 domain containing 1A	Homo sapiens	117-125
35309493-4	2022	In distilled water (d-water), the equilibrium water absorption capacity (EW) of the synthesized composite hydrogels (SAP-IPN1) is 1200 g (d-water/1g hydrogel) which is superior to any other commercial polyacrylate SAP hydrogels, while in saline water the EW is 650 g (s-water/1g hydrogel).	Water	245-250	SH2 domain containing 1A	Homo sapiens	117-125
35309493-4	2022	In distilled water (d-water), the equilibrium water absorption capacity (EW) of the synthesized composite hydrogels (SAP-IPN1) is 1200 g (d-water/1g hydrogel) which is superior to any other commercial polyacrylate SAP hydrogels, while in saline water the EW is 650 g (s-water/1g hydrogel).	Water	270-275	SH2 domain containing 1A	Homo sapiens	117-125
35309493-7	2022	The new SAP-IPN can work with commercial SAP, which is recommended for application as a water reservoir in arid land for irrigation for agriculture purposes.	Water	88-93	SH2 domain containing 1A	Homo sapiens	41-44
35172100-0	2022	Catalytic Mechanism of Competing Proton Transfer Events from Water and Acetic Acid by (CoII(bpbH2)Cl2) for Water Splitting Processes.	Water	107-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-91
35269497-6	2022	However, exposure of Tph2-/- animals to ethanol resulted in the normalization of water intake to the level of wild-type mice.	Water	81-86	tryptophan hydroxylase 2	Mus musculus	21-25
35172100-0	2022	Catalytic Mechanism of Competing Proton Transfer Events from Water and Acetic Acid by (CoII(bpbH2)Cl2) for Water Splitting Processes.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-91
35172100-1	2022	We performed first principles simulations to explore the water reduction process of the cobalt complex (CoII(bpbH2)Cl2), where bpbH2 = N,N"-bis(2"-pyridine carboxamide)-1,2-benzene.	Water	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-108
35172100-8	2022	The second proton transfer from water to the CoII-H moiety requires less free energy than acetic acid and is the rate-limiting step.	Water	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
35121106-8	2022	The specific inhibitor of Galectin-3, TD139 was found to ameliorate the clinical and histological manifestations of EAU mice.	Water	116-119	lectin, galactose binding, soluble 3	Mus musculus	26-36
35166520-0	2022	Integrated Bifunctional Electrodes Based on Amorphous Co-Ni-S Nanoflake Arrays with Atomic Dispersity of Active Sites for Overall Water Splitting.	Water	130-135	solute carrier family 5 member 5	Homo sapiens	57-61
35255957-12	2022	CONCLUSION: These results suggested that sEV-IL10 effectively ameliorates EAU by regulating the proliferation and differentiation of T-cells, indicating sEVs as a potential novel therapy for autoimmune uveitis or other autoimmune diseases.	Water	74-77	interleukin 10	Mus musculus	45-49
35107027-2	2022	In the mouse lens, this water transport through gap junction channels generates an intracellular hydrostatic pressure gradient, which is subjected to a dual feedback regulation that is mediated by the reciprocal modulation of the transient receptor potential vanilloid channels, TRPV1 and TRPV4.	Water	24-29	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	279-284
35107027-9	2022	Hence, our results suggest that the TRPV1/4 mediated feedback control of lens hydrostatic pressure operates to ensure that any fluctuations in lens water transport, and consequently water content, do not result in changes in lens power and therefore overall vision quality.	Water	148-153	TRPV1	Bos taurus	36-43
35107027-9	2022	Hence, our results suggest that the TRPV1/4 mediated feedback control of lens hydrostatic pressure operates to ensure that any fluctuations in lens water transport, and consequently water content, do not result in changes in lens power and therefore overall vision quality.	Water	182-187	TRPV1	Bos taurus	36-43
35122737-8	2022	In contrast, the water pore AQP0 displayed a high structural stability and an only faint effect on the surrounding membrane environment that is connected to its wedge-like shape.	Water	17-22	major intrinsic protein of lens fiber	Homo sapiens	28-32
35364923-8	2022	The optimized function was cL(rho)=0.35(rho-rhow)+ cL,w m/s, where w denotes water, giving the tested laminae a mean bulk density of 1600 +- 30 kg/m3 and a mean bulk cL of 1670 +- 60 m/s.	Water	77-82	rhodopsin	Homo sapiens	27-34
35299942-5	2022	At 6 months of age, prior to the onset of plaque pathology, E3, but not E4, protected against hAPP/Abeta-induced impairments in spatial memory retention in the Morris water maze.	Water	167-172	amyloid beta precursor protein	Homo sapiens	94-98
35299942-5	2022	At 6 months of age, prior to the onset of plaque pathology, E3, but not E4, protected against hAPP/Abeta-induced impairments in spatial memory retention in the Morris water maze.	Water	167-172	amyloid beta precursor protein	Homo sapiens	99-104
35124009-3	2022	Although it has been reported that PPARgamma agonists including thiazolidinediones can induce plasma volume expansion by enhancing renal sodium and water retention, the role of azPC in renal transport functions is unknown.	Water	148-153	peroxisome proliferator activated receptor gamma	Homo sapiens	35-44
34982299-0	2022	Deep Sea Water Alleviates Tau Phosphorylation and Cognitive Impairment via PI3K/Akt/GSK-3beta Pathway.	Water	9-14	AKT serine/threonine kinase 1	Homo sapiens	80-83
35006485-2	2022	Human insulin (Actrapid ) was labelled with fluorescein isothiocyanate (FITC) and the synthesised conjugate identified using reverse phase high performance liquid chromatography (RP-HPLC) on a C18 column and a gradient method with mobile phase A containing 0.1% trifluoroacetic acid (TFA) in Millipore water and mobile phase B containing 90% Acetonitrile, 10% Millipore water and 0.1% TFA.	Water	302-307	insulin	Homo sapiens	6-13
35006485-2	2022	Human insulin (Actrapid ) was labelled with fluorescein isothiocyanate (FITC) and the synthesised conjugate identified using reverse phase high performance liquid chromatography (RP-HPLC) on a C18 column and a gradient method with mobile phase A containing 0.1% trifluoroacetic acid (TFA) in Millipore water and mobile phase B containing 90% Acetonitrile, 10% Millipore water and 0.1% TFA.	Water	370-375	insulin	Homo sapiens	6-13
35104488-4	2022	Catalase decomposes hydrogen peroxide into water and oxygen with the release of energy.	Water	43-48	catalase	Homo sapiens	0-8
35270394-6	2022	DEHP and DBP were the dominant PAEs in the middle-lower Hanjiang River in surface water and sediments.	Water	82-87	D-box binding PAR bZIP transcription factor	Homo sapiens	9-12
35270394-7	2022	SPSS analysis showed that dissolved organic carbon (DOC) in surface water was significantly correlated with the concentration of DBP, DEHP, and the  6PAEs, while organic matter (OM) was significantly correlated with the concentration of the  6PAEs in sediments.	Water	68-73	D-box binding PAR bZIP transcription factor	Homo sapiens	129-132
35108001-5	2022	Ligand optimization resulted in the displacement of a coordinated water molecule from the Keap1 binding site and a significantly altered thermodynamic profile.	Water	66-71	kelch like ECH associated protein 1	Homo sapiens	90-95
35166284-5	2022	The detection limits of Pb(II), As(III), and Hg(II) are 2.6, 1.5, and 4.2 mug L-1, all lower than the permissible limits of the WHO for drinking water (the permissible level of Pb(II) and As(III) is 10.0 mug L-1, and the permissible level of Hg(II) is 6.0 mug L-1), respectively.	Water	145-150	submaxillary gland androgen regulated protein 3B	Homo sapiens	24-30
35142761-0	2022	Fast, sensitive and selective simultaneous determination of paraquat and glyphosate herbicides in water samples using a compact electrochemical sensor.	Water	98-103	Fas activated serine/threonine kinase	Homo sapiens	0-4
35195865-6	2022	In comparison with raw sludge, adsorption water proportion in TB-EPS and S-EPS was reduced after lysozyme (LZM) or freezing-thaw conditioning, which was ascribed to reduction of EPS viscosity and the weakness of water adsorption capacity.	Water	42-47	lysozyme	Homo sapiens	97-105
35142217-1	2022	Fog collection is an effective method for addressing water shortages in arid areas.	Water	53-58	zinc finger protein, FOG family member 1	Homo sapiens	0-3
35142217-8	2022	This surface allows for the simultaneous collection and detection of fog, which can provide insights into the preparation of Janus multifunction structures and how such structures can play a key role in the subsequent purification and usage of water resources.	Water	244-249	zinc finger protein, FOG family member 1	Homo sapiens	69-72
35195865-6	2022	In comparison with raw sludge, adsorption water proportion in TB-EPS and S-EPS was reduced after lysozyme (LZM) or freezing-thaw conditioning, which was ascribed to reduction of EPS viscosity and the weakness of water adsorption capacity.	Water	42-47	lysozyme	Homo sapiens	107-110
35195865-6	2022	In comparison with raw sludge, adsorption water proportion in TB-EPS and S-EPS was reduced after lysozyme (LZM) or freezing-thaw conditioning, which was ascribed to reduction of EPS viscosity and the weakness of water adsorption capacity.	Water	212-217	lysozyme	Homo sapiens	97-105
35195865-6	2022	In comparison with raw sludge, adsorption water proportion in TB-EPS and S-EPS was reduced after lysozyme (LZM) or freezing-thaw conditioning, which was ascribed to reduction of EPS viscosity and the weakness of water adsorption capacity.	Water	212-217	lysozyme	Homo sapiens	107-110
35195865-10	2022	In addition, after LZM or freezing-thaw conditioning, the sludge particle size significantly increased after TB-EPS extraction, while the sludge particle more easily absorbed water molecules, thereby increasing adsorption water and capillary water within the sludge flocs.	Water	175-180	lysozyme	Homo sapiens	19-22
35195865-10	2022	In addition, after LZM or freezing-thaw conditioning, the sludge particle size significantly increased after TB-EPS extraction, while the sludge particle more easily absorbed water molecules, thereby increasing adsorption water and capillary water within the sludge flocs.	Water	222-227	lysozyme	Homo sapiens	19-22
35195865-10	2022	In addition, after LZM or freezing-thaw conditioning, the sludge particle size significantly increased after TB-EPS extraction, while the sludge particle more easily absorbed water molecules, thereby increasing adsorption water and capillary water within the sludge flocs.	Water	242-247	lysozyme	Homo sapiens	19-22
35090651-5	2022	BANP was found to be a turn-on fluorescent probe for DBP in water with a detection limit of 0.13 mug/g; the DBP-water system acts as a hydrogen bond switch to turn on the fluorescence.	Water	60-65	BTG3 associated nuclear protein	Homo sapiens	0-4
35090651-5	2022	BANP was found to be a turn-on fluorescent probe for DBP in water with a detection limit of 0.13 mug/g; the DBP-water system acts as a hydrogen bond switch to turn on the fluorescence.	Water	112-117	BTG3 associated nuclear protein	Homo sapiens	0-4
35090651-8	2022	Taken together, BANP is a DBP-responsive probe for sensitive DBP detection in water, cells, and fish meats.	Water	78-83	BTG3 associated nuclear protein	Homo sapiens	16-20
35135190-1	2022	We have designed and synthesized two unprecedented microporous three-dimensional metal-organic frameworks, {(Cd6(TPOM)3(L)6) 12DMF 3H2O}n (1) and {(Zn2(TPOM)(L)2) 2DMF H2O}n (2), based on a flexible quadritopic ligand, tetrakis(4-pyridyloxymethylene)methane (TPOM), and a bent dicarboxylic acid, 4,4"-(dimethylsilanediyl)bis-benzoic acid (H2L).	Water	168-171	CD6 molecule	Homo sapiens	109-112
35192167-0	2022	Water quality index modeling using random forest and improved SMO algorithm for support vector machine in Saf-Saf river basin.	Water	0-5	FAS antisense RNA 1	Homo sapiens	106-109
35192167-0	2022	Water quality index modeling using random forest and improved SMO algorithm for support vector machine in Saf-Saf river basin.	Water	0-5	FAS antisense RNA 1	Homo sapiens	110-113
35203238-0	2022	The Role of Aquaporin 7 in the Movement of Water and Cryoprotectants in Bovine In Vitro Matured Oocytes.	Water	43-48	aquaporin-7	Bos taurus	12-23
35203238-7	2022	AQP7 facilitated water diffusion when bovine MII oocytes were in presence of Me2SO solution but not EG or sucrose solution.	Water	17-22	aquaporin-7	Bos taurus	0-4
35203238-10	2022	Water diffusion appears to be improved when AQP7 overexpressed oocytes are exposed to Me2SO, shortening the time required for oocytes to achieve osmotic balance with cryoprotectant solutions.	Water	0-5	aquaporin-7	Bos taurus	44-48
35192167-2	2022	This research constructs a hybrid artificial intelligence model namely sequential minimal optimization-support vector machine (SMO-SVM) along with random forest (RF) as a benchmark model for predicting water quality values at the Wadi Saf-Saf river basin in Algeria.	Water	202-207	FAS antisense RNA 1	Homo sapiens	235-238
35192167-2	2022	This research constructs a hybrid artificial intelligence model namely sequential minimal optimization-support vector machine (SMO-SVM) along with random forest (RF) as a benchmark model for predicting water quality values at the Wadi Saf-Saf river basin in Algeria.	Water	202-207	FAS antisense RNA 1	Homo sapiens	239-242
35157081-3	2022	Competition for water among plants is often assumed to be size-symmetric, i.e., exponents (beta1) of power functions (water use   biomassbeta1) equal to 1, with all sizes using the same amount of water proportionally to their size.	Water	16-21	BCL2 related protein A1	Homo sapiens	91-96
35107451-9	2022	At the interface of the Mpro dimer, we detected three regions that are rich in interfacial water which stabilize the SARS-CoV-2 Mpro dimer by forming hydrogen bonds with two protomers.	Water	91-96	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	24-28
35107451-9	2022	At the interface of the Mpro dimer, we detected three regions that are rich in interfacial water which stabilize the SARS-CoV-2 Mpro dimer by forming hydrogen bonds with two protomers.	Water	91-96	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	128-132
35107451-10	2022	The key residues and rich water regions provide important targets for the future design of anti-SARS-CoV-2 drugs through inhibiting Mpro dimerization.	Water	26-31	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	132-136
35063895-2	2022	Original CD4 mimics such as NBD-556, which has an aromatic ring, an oxalamide linker and a piperidine moiety, possess significant anti-HIV activity but with their hydrophobic aromatic ring-containing structures are poorly soluble in water.	Water	233-238	CD4 molecule	Homo sapiens	9-12
35157081-3	2022	Competition for water among plants is often assumed to be size-symmetric, i.e., exponents (beta1) of power functions (water use   biomassbeta1) equal to 1, with all sizes using the same amount of water proportionally to their size.	Water	118-123	BCL2 related protein A1	Homo sapiens	91-96
35157081-10	2022	Spatial comparisons across the entire data set showed that beta1 correlated only weakly (R2 < 12%) with stand structure or climate, suggesting that inter-specific variability in beta1 and hence the symmetry of competition for water may be largely related to inter-specific differences in tree architecture or physiology rather than to climate or stand structure.	Water	226-231	BCL2 related protein A1	Homo sapiens	59-64
35151337-13	2022	CONCLUSIONS: Apoptotic changes and altered AQP-1 expression may contribute to CPEC dysfunction and subsequently reduce cerebrospinal fluid production, affecting the water homeostasis in the brains of patients with CM.	Water	165-170	aquaporin 1 (Colton blood group)	Homo sapiens	43-48
35224360-2	2022	Compared to pure CFP, applying PTFE on the CFP increases the breakthrough pressure by 0.2 times, while it decreases the water flow rate at initial penetration by 0.06 times, owing to the strong hydrophobicity of PTFE-CFP.	Water	120-125	complement factor properdin	Homo sapiens	17-20
35138533-8	2022	But when there is 0.1 M Ca2+ or Mg2+ in the water, the order of Cd2+ adsorption capacity becomes TNT/HC (44.28, 49.04 mg/g) > TNT/C (58.84, 69.32 mg/g) > TNT (65.52, 70.6 mg/g).	Water	44-49	troponin T2, cardiac type	Homo sapiens	126-131
35118802-9	2022	At T3, there was no difference in distilled water groups, while the statistically highest DeltaE00 were obtained in TPF and GCP in coffee, cola and wine.	Water	44-49	golgin B1	Homo sapiens	124-127
35089712-5	2022	The composition dependences of Tr and DeltaHr in H2O-imidazole mixtures were analyzed with linear cooperative transition theory for the solvent-stabilizing effect in the mixture with active compounds.	Water	49-52	coagulation factor II thrombin receptor	Homo sapiens	31-33
35162013-6	2022	However, the compression and water level decrease tests showed that the system (R2 = 0.97142) had greater linearity with FBG2 (0.94123) and lower linearity with FBG1 (0.98271).	Water	29-34	F-box protein 2	Homo sapiens	161-165
35137852-1	2022	Hypovolemia induced by hemorrhage is a common clinical complication, which stimulates vasopressin (AVP) secretion by the neurohypophysis in order to retain body water and maintain blood pressure.	Water	161-166	arginine vasopressin	Homo sapiens	86-97
35137852-1	2022	Hypovolemia induced by hemorrhage is a common clinical complication, which stimulates vasopressin (AVP) secretion by the neurohypophysis in order to retain body water and maintain blood pressure.	Water	161-166	arginine vasopressin	Homo sapiens	99-102
35121663-3	2022	Human exposure risk, given water contact, is driven by the production of free-living cercariae by snail populations.	Water	27-32	snail family transcriptional repressor 1	Homo sapiens	98-103
35159611-3	2022	In contrast, MCC-SPI gels exhibited decreased water-holding capacity, gel strength, and viscoelastic modulus.	Water	46-51	chromogranin A	Homo sapiens	17-20
35051764-1	2022	Karst water as the vital water supply source is generally suffered from NO3- contamination in intensive agricultural areas worldwide.	Water	6-11	NBL1, DAN family BMP antagonist	Homo sapiens	72-75
35043137-2	2022	Herein, we report a reductant-free reductive (3 + 2 + 1) annulation of beta-keto amides with CS2 enabled by the synergy of electro/copper/base using water as an innocuous anodic sacrifice with O2 as a sustainable by-product.	Water	149-154	chorionic somatomammotropin hormone 2	Homo sapiens	93-96
35051764-4	2022	The results showed that the NO3- concentrations ranged from the below detection limit to 117 mg/L, with 30.8% of GW samples obtained from the north central part of the study area exceeding the maximum permissible limit for drinking water, and posing significant non-carcinogenic health risks for native people through drinking water pathway.	Water	232-237	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
35051764-4	2022	The results showed that the NO3- concentrations ranged from the below detection limit to 117 mg/L, with 30.8% of GW samples obtained from the north central part of the study area exceeding the maximum permissible limit for drinking water, and posing significant non-carcinogenic health risks for native people through drinking water pathway.	Water	327-332	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
35060724-5	2022	Compared with the alpha2-helix structure in water, the membrane stabilizes the structure of the alpha2-helix, whereas the unfolding of the alpha2-helix reduces the binding affinity of P2 on the membrane.	Water	44-49	glycoprotein hormone subunit alpha 2	Homo sapiens	96-102
35074739-12	2022	In addition, AOM exhibited to be more toxic to the colon in the nitrite-treated mice in comparison with normal water-treated mice, and it might be due to the expression of Hspa1a and Hspa1b in the colon.	Water	111-116	heat shock protein 1B	Mus musculus	183-189
35051764-1	2022	Karst water as the vital water supply source is generally suffered from NO3- contamination in intensive agricultural areas worldwide.	Water	25-30	NBL1, DAN family BMP antagonist	Homo sapiens	72-75
35091547-0	2022	Decisive role of water and protein dynamics in residence time of p38alpha MAP kinase inhibitors.	Water	17-22	mitogen-activated protein kinase 14	Homo sapiens	65-73
35161367-8	2022	The Arabidopsis boron transport mutant, bor1, expressed greater water loss and, based on the lesion area of leaf tissue, a greater susceptibility to Colletotrichum higginsianum and Botrytis cinerea.	Water	64-69	HCO3- transporter family	Arabidopsis thaliana	40-44
35559994-13	2022	We also identified a cluster of genes (Krt8, Krt7, Cldn4, and Aqp3) that exerted functional roles in cell-cell junctions and water homeostasis during hatching.	Water	125-130	aquaporin 3	Mus musculus	62-66
35225386-5	2022	Compared to Gwp, Gcp had higher weight (80.0 vs. 64.2 kg), body mass index (BMI) (26 vs. 20.8 kg m-2 ), body surface area (BSA) (1.94 vs. 1.78 m2 ), waist-to-hip ratio (WHR) (87.29% vs. 80.23%), body circumferences (except for forearm circumference), skinfold thickness of all the local parts, volume of expired air (VE) (50.97 vs. 40.81 L/min), and body fat rate (BFR) (24.44% vs. 14.07%), but had a lower specific surface area (SSA) (0.02477 vs. 0.02791 m2 /kg), resting metabolic rate (RMR) per kilogram (1.21 vs. 1.47 W/kg), diastolic blood pressure (DBP) (65.30 vs. 74.69 mmHg), and percentages of muscle (71.17% vs. 80.95%), total water (55.35% vs. 63.14%), skeletal muscle (42.47% vs. 47.94%), protein (14.90% vs. 16.94%), inorganic salt (5.29% vs. 5.86%), and bone mineral (0.044% vs. 0.048%).	Water	637-642	golgin B1	Homo sapiens	17-20
35126516-8	2022	Altogether, incorporation of Nintedanib into folate modified albumin microspheres is a new approach to improve water solubility and targeting effect of the drug.	Water	111-116	albumin	Homo sapiens	61-68
35015542-8	2022	In the case of the hydrophobic amino acids in the protein lysozyme, the slow down in the thermal relaxation relative to that in water appears to be controlled primarily by the size of the side chain.	Water	128-133	lysozyme	Homo sapiens	58-66
34991150-4	2022	The Co(II) complex with 3,9-PC2AMtBu shows a similar six-coordinate structure in the solid state, while the Co(II) complex with 3,9-PC2AMH contains a seven-coordinate metal ion, seventh coordination being completed by the presence of an inner-sphere water molecule.	Water	250-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
35014636-5	2022	A new binding mode of CYP2D6 is defined, and two key residues (residue Asp301 and residue Glu216) are discovered working simultaneously to stabilize the DM at the reactive site by forming water bridge hydrogen bonds when CYP2D6 binds DM.	Water	188-193	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	22-28
35014636-5	2022	A new binding mode of CYP2D6 is defined, and two key residues (residue Asp301 and residue Glu216) are discovered working simultaneously to stabilize the DM at the reactive site by forming water bridge hydrogen bonds when CYP2D6 binds DM.	Water	188-193	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	221-227
35082168-8	2022	Recombinant PGRN significantly reduced EAU severity in association with a decreased frequency of Th17 and Th1 cells.	Water	39-42	granulin precursor	Homo sapiens	12-16
35076718-1	2022	The occurrence and health risk of hexabromocyclododecane (HBCD), a brominated flame retardant with its three diastereoisomers, in drinking water sources in the lower Yangtze River in China was investigated.	Water	139-144	amyloid beta precursor protein	Homo sapiens	65-66
34991150-4	2022	The Co(II) complex with 3,9-PC2AMtBu shows a similar six-coordinate structure in the solid state, while the Co(II) complex with 3,9-PC2AMH contains a seven-coordinate metal ion, seventh coordination being completed by the presence of an inner-sphere water molecule.	Water	250-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
34991150-10	2022	The presence of highly shifted 1H NMR signals due to the amide protons in slow exchange with bulk water results in sizeable CEST signals, which are observed at +67 and +15 ppm for the Co(II) complex with 3,9-PC2AMH and +42 and +7 ppm for the Ni(II) analogue at 25  C.	Water	98-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
34985089-10	2022	Animal experiments revealed that both PM water extract and its susceptibility component of liver injury, cis-stilbene glucoside, could cause liver injury in the mice pre-stimulated using TNF-alpha.	Water	41-46	tumor necrosis factor	Mus musculus	187-196
35159734-0	2022	Advancement of Fluorescent and Structural Properties of Bovine Serum Albumin-Gold Bioconjugates in Normal and Heavy Water with pH Conditioning and Ageing.	Water	116-121	albumin	Homo sapiens	63-76
35155954-0	2022	Composition of Formation Water and Natural Gas as an Indicator of Shale Gas Preservation Conditions: A Case Study of the Marine Shale of the Niutitang Formation in the Cengong Block in Northern Guizhou, China.	Water	25-30	PAXIP1 associated glutamate rich protein 1	Homo sapiens	72-75
35128288-1	2022	A gas-solid separation fluidized bed, which belongs to dry separation and can save a lot of water resources, is an important method for coal quality improvement.	Water	92-97	PAXIP1 associated glutamate rich protein 1	Homo sapiens	2-5
35160450-5	2022	Firstly, we investigated albumin dynamics and calculated electrostatic surfaces at experimental pH values in water by using molecular dynamics methods.	Water	109-114	albumin	Homo sapiens	25-32
35057802-2	2022	These neurons are connected with the pituitary gland, subsequently producing antidiuretic hormone to reabsorb water from urine in the kidneys, and to the forebrain to generate thirst and trigger drinking behavior.	Water	110-115	arginine vasopressin	Homo sapiens	77-97
35065580-4	2022	Besides water adsorption bands, linearly bonded CO, bridge-bonded CO, adsorbed formate, adsorbed formic acid, and adsorbed CHO bands were observed by ATR-FTIR spectroscopy during methanol and formic acid oxidation on Pt.	Water	8-13	ATR serine/threonine kinase	Homo sapiens	150-153
35160409-1	2022	Combining the characteristics of rare earth extractants and water-soluble polymer complexants, a novel complexant phosphorylated chitosan (PCS) was synthesized by Kabachnik-Fields reaction with alkalized chitosan, dimethyl phosphonate, and formaldehyde as raw materials and toluene-4-sulfonic acid monohydrate (TsOH) as catalyst.	Water	60-65	PCS	Homo sapiens	139-142
35160409-4	2022	The results indicate that the PCS has better water solubility compared with chitosan and good complex ability to rare earths, which can be used for rare earth separation by the complexation-ultrafiltration process.	Water	45-50	PCS	Homo sapiens	30-33
35051932-1	2022	INTRODUCTION: Water homeostasis is achieved by secretion of peptide hormones arginine vasopressin (AVP) and oxytocin (OXT) that are synthesised by separate populations of magnocellular neurones (MCNs) in the hypothalamus.	Water	14-19	arginine vasopressin	Rattus norvegicus	86-97
35048226-9	2022	Total ingested liquid including purgative and water was lower in the 2L PEG + Asc group (2.9 L) than in the 4L PEG group (4.2 L, P < 0.001).	Water	46-51	PYD and CARD domain containing	Homo sapiens	78-81
35051932-1	2022	INTRODUCTION: Water homeostasis is achieved by secretion of peptide hormones arginine vasopressin (AVP) and oxytocin (OXT) that are synthesised by separate populations of magnocellular neurones (MCNs) in the hypothalamus.	Water	14-19	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	108-116
35051932-1	2022	INTRODUCTION: Water homeostasis is achieved by secretion of peptide hormones arginine vasopressin (AVP) and oxytocin (OXT) that are synthesised by separate populations of magnocellular neurones (MCNs) in the hypothalamus.	Water	14-19	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	118-121
35276816-4	2022	We found that unimproved water access was linked to a lower likelihood of achieving dietary diversity (OR = 0.65, 95% CI 0.44 to 0.98, p = 0.039); lower height-for-age z-score (beta = -0.34, 95% CI -0.49 to -0.19, p < 0.001) and hemoglobin concentration (beta = -2.78, 95% CI -5.16 to -0.41, p = 0.022); higher odds of stunting (OR = 1.50, 95% CI 1.01 to 2.25, p = 0.047) and anemia (OR = 1.34, 95% CI 1.02 to 1.77, p = 0.037).	Water	25-30	ATPase H+ transporting V0 subunit a2	Homo sapiens	255-264
35200618-6	2022	The results obtained showed that at low concentration (1 g L-1), alginate stimulated PAL activity in date palm roots 5 times more compared to the negative control (water-treated) after 24 h following treatment and 2.5 times more compared to the laminarin used as a positive stimulator of plant natural defenses (positive control of induction).	Water	164-169	phenylalanine ammonia-lyase	Phoenix dactylifera	85-88
34985293-2	2022	The organization of saturated tristearin (C18:0) monolayer was probed thanks to grazing incidence X-ray diffraction: one observes a hexagonal packing of the chains perpendicular to the air-water interface, in contrast to what is described in the literature.	Water	189-194	Bardet-Biedl syndrome 9	Homo sapiens	42-45
35095982-6	2021	In this study, a kind of all-solid ISE system combined with a temperature sensor and a pH electrode is proposed to automatically measure the concentrations of the NO 3 -  -N. In this study, a soil water content calibration function was established, which significantly reduces a relative error (RE) by 13.09%.	Water	197-202	NBL1, DAN family BMP antagonist	Homo sapiens	163-167
35023456-6	2022	METHODS: Water in oil in water (W-O-W) microemulsion solvent evaporation technique was used for the preparation of nanoparticles consisting from positively charged poly (D, L-lactide-co-glycolide) coated with chitosan and loaded with insulin.	Water	9-14	insulin	Homo sapiens	234-241
35023456-6	2022	METHODS: Water in oil in water (W-O-W) microemulsion solvent evaporation technique was used for the preparation of nanoparticles consisting from positively charged poly (D, L-lactide-co-glycolide) coated with chitosan and loaded with insulin.	Water	25-30	insulin	Homo sapiens	234-241
35205859-6	2022	Office-derived indoor water samples (n = 4/4) were toxic to human THP-1 macrophages.	Water	22-27	GLI family zinc finger 2	Homo sapiens	66-71
35049597-2	2022	In all situations, CMC1 values of CPC + PVP system were found to be higher in water than in attendance of salts (NaCl and Na2SO4).	Water	78-83	C-X9-C motif containing 1	Homo sapiens	19-23
35095982-2	2021	During the period of precipitation or irrigation, an excessive NO 3 -  -N readily causes its leaching or runoff from the soil surface to rivers due to inaccurate fertilization and water management, leading to non-point source pollution.	Water	180-185	NBL1, DAN family BMP antagonist	Homo sapiens	63-67
35095982-4	2021	Ion-selective electrodes (ISEs) support the possibility of NO 3 -  -N measurement by measuring the nitrate ( NO 3 -  ) ions in soil quickly and accurately due to the high water solubility and mobility of NO 3 -  ions.	Water	171-176	NBL1, DAN family BMP antagonist	Homo sapiens	59-63
35095982-4	2021	Ion-selective electrodes (ISEs) support the possibility of NO 3 -  -N measurement by measuring the nitrate ( NO 3 -  ) ions in soil quickly and accurately due to the high water solubility and mobility of NO 3 -  ions.	Water	171-176	NBL1, DAN family BMP antagonist	Homo sapiens	109-113
35425273-4	2022	It is found that a considerable blue-shift of Csp2 -H stretching frequency in the Csp2 -H O H-bond is mainly determined by an addition of water into the complexes along with the low polarity of the Csp2 -H covalent bond in formaldehyde and acetaldehyde.	Water	138-143	regulator of calcineurin 2	Homo sapiens	82-86
35425273-0	2022	Importance of water and intramolecular interaction governs substantial blue shift of Csp2 -H stretching frequency in complexes between chalcogenoaldehydes and water.	Water	14-19	regulator of calcineurin 2	Homo sapiens	85-89
35425273-4	2022	It is found that a considerable blue-shift of Csp2 -H stretching frequency in the Csp2 -H O H-bond is mainly determined by an addition of water into the complexes along with the low polarity of the Csp2 -H covalent bond in formaldehyde and acetaldehyde.	Water	138-143	regulator of calcineurin 2	Homo sapiens	198-202
35425273-0	2022	Importance of water and intramolecular interaction governs substantial blue shift of Csp2 -H stretching frequency in complexes between chalcogenoaldehydes and water.	Water	159-164	regulator of calcineurin 2	Homo sapiens	85-89
35425273-4	2022	It is found that a considerable blue-shift of Csp2 -H stretching frequency in the Csp2 -H O H-bond is mainly determined by an addition of water into the complexes along with the low polarity of the Csp2 -H covalent bond in formaldehyde and acetaldehyde.	Water	138-143	regulator of calcineurin 2	Homo sapiens	46-50
35425273-7	2022	Upon the addition of H2O into the binary systems, halogenated complexes witness a decreasing magnitude of the Csp2 -H stretching frequency blue-shift in the Csp2 -H O H-bond, whereas CH3-substituted complexes experience the opposite trend.	Water	21-24	regulator of calcineurin 2	Homo sapiens	110-114
35425273-7	2022	Upon the addition of H2O into the binary systems, halogenated complexes witness a decreasing magnitude of the Csp2 -H stretching frequency blue-shift in the Csp2 -H O H-bond, whereas CH3-substituted complexes experience the opposite trend.	Water	21-24	regulator of calcineurin 2	Homo sapiens	157-161
35087537-7	2021	Drinking the DSS-supplementing water also increased disease activity index (DAI) and serum urea nitrogen level (P <0.05), shortened colonic length (P <0.05), impaired colonic enterocyte apoptosis, cell cycle, and the ZO-1 mRNA expression (P <0.05), increased the ratio of CD11c-, CD64-, and CD169-positive cells in colon (P <0.05), and induced extensive ulcer, infiltration of inflammatory cells, and collagenous fiber hyperplasia in colon.	Water	31-36	tight junction protein 1	Homo sapiens	217-221
35013892-6	2022	Furthermore, high relative humidity greater than 83% near the ground indicates a high condensation rate for water vapors to form fog near the ground.	Water	108-113	zinc finger protein, FOG family member 1	Homo sapiens	129-132
34983480-20	2022	CONCLUSION: These results show that QAF water extract effectively prevents skin photoaging by enhancing collagen deposition and inhibiting MMP-1 via the ERK/AP-1 signaling pathway.	Water	40-45	mitogen-activated protein kinase 1	Homo sapiens	153-156
35071853-6	2022	A few species such as water-soluble organic and inorganic carbon (WSOC and WSIC), K+, SO4 2-, and NO3 -, owing to their hygroscopic nature, were efficiently scavenged, resulting in their lower concentration within the interstitial aerosol during fog episodes.	Water	22-27	NBL1, DAN family BMP antagonist	Homo sapiens	98-101
35071853-6	2022	A few species such as water-soluble organic and inorganic carbon (WSOC and WSIC), K+, SO4 2-, and NO3 -, owing to their hygroscopic nature, were efficiently scavenged, resulting in their lower concentration within the interstitial aerosol during fog episodes.	Water	22-27	zinc finger protein, FOG family member 1	Homo sapiens	246-249
35087426-7	2021	In addition, CGRP is able to stimulate ion and water secretion into the intestinal lumen.	Water	47-52	calcitonin related polypeptide alpha	Homo sapiens	13-17
35087426-9	2021	We therefore conclude that the constipation elicited by antibodies targeting CGRP or its receptor results from interference with the physiological function of CGRP in the small and large intestine in which it contributes to the maintenance of peristaltic motor activity, ion and water secretion and intestinal transit.	Water	279-284	calcitonin related polypeptide alpha	Homo sapiens	77-81
35087426-9	2021	We therefore conclude that the constipation elicited by antibodies targeting CGRP or its receptor results from interference with the physiological function of CGRP in the small and large intestine in which it contributes to the maintenance of peristaltic motor activity, ion and water secretion and intestinal transit.	Water	279-284	calcitonin related polypeptide alpha	Homo sapiens	159-163
34877950-1	2022	Divalent transition metals such as Co(II) are important targets for removal from water sources, due to their potential toxicity as well as their high value.	Water	81-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
34983480-20	2022	CONCLUSION: These results show that QAF water extract effectively prevents skin photoaging by enhancing collagen deposition and inhibiting MMP-1 via the ERK/AP-1 signaling pathway.	Water	40-45	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-161
35009482-6	2022	After various powder recycling events, no significant deterioration in tensile properties was measured, indicating that the water atomized powder could be a sustainable feedstock candidate for L-PBF.	Water	124-129	PTTG1 interacting protein	Homo sapiens	195-198
35155866-13	2022	The vasopressin-mediated water reabsorption was activated more in females than males irrespective of tolvaptan administration.	Water	25-30	arginine vasopressin	Homo sapiens	4-15
35008929-4	2022	We concluded that CAM-based therapies have demonstrated benefits for controlling EAU severity with decreases in immune cell migration, especially via ICAM-1/LFA-1 and VCAM-1/VLA-4 (integrin) pathways.	Water	81-84	calmodulin 3	Homo sapiens	18-21
35008929-4	2022	We concluded that CAM-based therapies have demonstrated benefits for controlling EAU severity with decreases in immune cell migration, especially via ICAM-1/LFA-1 and VCAM-1/VLA-4 (integrin) pathways.	Water	81-84	vascular cell adhesion molecule 1	Homo sapiens	167-173
35145895-8	2022	Notably, the 400 mg/kg dose of cold-water extract was more effective than metformin in reduction of TNF-alpha and IL-6 (p<0.01 and p<0.05, respectively).	Water	36-41	tumor necrosis factor	Mus musculus	100-109
35145895-8	2022	Notably, the 400 mg/kg dose of cold-water extract was more effective than metformin in reduction of TNF-alpha and IL-6 (p<0.01 and p<0.05, respectively).	Water	36-41	interleukin 6	Mus musculus	114-118
35228389-1	2022	We previously isolated an aminobutadiene derivative as a by-product in the synthesis of a 1,4-dihydropyridine (1,4-DHP) derivative by the reaction of methyl propiolate with excess ammonium acetate in water, and we proposed that it is an intermediate in the formation of 1,4-DHP.	Water	200-205	dihydropyrimidinase	Homo sapiens	115-118
35228389-1	2022	We previously isolated an aminobutadiene derivative as a by-product in the synthesis of a 1,4-dihydropyridine (1,4-DHP) derivative by the reaction of methyl propiolate with excess ammonium acetate in water, and we proposed that it is an intermediate in the formation of 1,4-DHP.	Water	200-205	dihydropyrimidinase	Homo sapiens	274-277
35228389-6	2022	These results suggest that the predominant reaction pathway from the intermediate to 1,4-DHP in water involves Michael addition of a second amine molecule and reaction with methyl propiolate, followed by intramolecular cyclization and elimination of amine.	Water	96-101	dihydropyrimidinase	Homo sapiens	89-92
35309246-11	2022	Literature shows that fog is being harnessed to address water insecurity in various countries, however, coastal areas of Angola, Namibia and South Africa, Kenya, Eastern Yemen, Oman, China, India, Sri Lanka, Mexico, along with the mountainous regions of Peru, Chile, and Ecuador, are some of the potential sites that can benefit from the installation of fog water harvesting systems.	Water	56-61	zinc finger protein, FOG family member 1	Homo sapiens	22-25
35309246-11	2022	Literature shows that fog is being harnessed to address water insecurity in various countries, however, coastal areas of Angola, Namibia and South Africa, Kenya, Eastern Yemen, Oman, China, India, Sri Lanka, Mexico, along with the mountainous regions of Peru, Chile, and Ecuador, are some of the potential sites that can benefit from the installation of fog water harvesting systems.	Water	56-61	zinc finger protein, FOG family member 1	Homo sapiens	354-357
35309246-11	2022	Literature shows that fog is being harnessed to address water insecurity in various countries, however, coastal areas of Angola, Namibia and South Africa, Kenya, Eastern Yemen, Oman, China, India, Sri Lanka, Mexico, along with the mountainous regions of Peru, Chile, and Ecuador, are some of the potential sites that can benefit from the installation of fog water harvesting systems.	Water	358-363	zinc finger protein, FOG family member 1	Homo sapiens	22-25
35002068-5	2022	Intermediate urine osmolality and markedly high plasma AVP levels were observed in the water deprivation test.	Water	87-92	arginine vasopressin	Homo sapiens	55-58
35059257-0	2022	Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial.	Water	27-32	insulin	Homo sapiens	85-92
35060824-4	2021	Herein, we review in vivo genotoxicity studies for Cr(VI) to inform the MOA for Cr(VI)-induced tumors observed in a two-year cancer bioassay in mice and rats exposed via drinking water.	Water	179-184	periphilin 1	Mus musculus	80-86
35306010-6	2022	Also, the fragrance-released beta-CD-Cel composite film showed high transparency, strong water resistance, and good flexibility.	Water	89-94	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	29-36
35275056-5	2021	Clinically, in patients with inappropriate antidiuresis syndrome (SIAD), the apelin/AVP balance is altered, which contributes to water metabolism defect.	Water	129-134	apelin	Homo sapiens	77-83
35275056-5	2021	Clinically, in patients with inappropriate antidiuresis syndrome (SIAD), the apelin/AVP balance is altered, which contributes to water metabolism defect.	Water	129-134	arginine vasopressin	Homo sapiens	84-87
35356115-4	2022	Considering an active involvement of the aquaporin (AQP) genes in water transport and desiccation tolerance besides several basic functions, their potential role in abiotic stress tolerance was systematically characterized and functionally validated.	Water	66-71	aquaporin PIP2-7-like	Nicotiana tabacum	41-50
2589964-7	1989	Thus, the lungs of the TNF-treated rats were stiffer, with reduced compliance values, and heavier due to increased water content and increased cellularity.	Water	115-120	tumor necrosis factor-like	Rattus norvegicus	23-26
2558010-0	1989	Crosslinking of cytochrome c and cytochrome b5 with a water-soluble carbodiimide.	Water	54-59	LOC104968582	Bos taurus	16-28
2632071-4	1989	The C-3 substituent affects the physicochemical and biochemical properties of POM ester, such as lipophilicity, water solubility, chemical stability and enzymatic stability.	Water	112-117	complement component 3	Mus musculus	4-7
2632071-12	1989	The effect of the C-3 substituent on water solubility was not important for the absorption of cephalosporin employed in the present study.	Water	37-42	complement component 3	Mus musculus	18-21
2583289-1	1989	The water soluble carbodiimide N-cyclohexyl-N"-2-morpholinoethyl-carbodiimide-methyl-p-toluolsulfona te was found to effectively covalently cross-link pancreatic colipase to lipase as evidenced by Western blotting experiments using antibodies directed either against lipase or colipase.	Water	4-9	colipase	Equus caballus	162-170
2552916-0	1989	Effects of inhibitors of the renin-angiotensin system on water intake after insulin administration.	Water	57-62	renin	Rattus norvegicus	29-34
2622326-4	1989	The treponemal butanol/water extract did induce production of IL-1 and TNF but at doses 5- to 50-fold higher than E. coli LPS.	Water	23-28	tumor necrosis factor	Sus scrofa	71-74
2527852-7	1989	Comparison of data obtained for micellar solutions of tryptophan or ATPase indicated that the tryptophan residues in the protein are protected from exposure to water.	Water	160-165	dynein axonemal heavy chain 8	Homo sapiens	68-74
2527852-8	1989	Correlation of water effects on emission intensity and lifetimes suggested that interaction with solvent may result in structural changes that cause a mixture of dynamic and static quenching of ATPase intrinsic fluorescence.	Water	15-20	dynein axonemal heavy chain 8	Homo sapiens	194-200
2569390-6	1989	The water-soluble fraction (infranatant) of rat milk contained immunoreactive (ir) rat GH-releasing hormone (rGHRH)-like material (725.06 +/- 81.29 pg/ml), ir-somatostatin-like activity (1.64 +/- 0.2 ng/ml), and irGH (4.79 +/- 0.73 ng/ml).	Water	4-9	growth hormone releasing hormone	Rattus norvegicus	109-114
16667006-2	1989	When axis-detached cotyledons were imbibed in water with seed-coats attached, alpha-amylase activity did not increase and remained low.	Water	46-51	alpha-amylase	Vigna radiata	78-91
2490218-6	1989	Adhesive strength to etched dentin : P-30 diluted with Enamel Bond showed the highest values of 64 kg/cm2 after 24-hour immersion in water, and 63 kg/cm2 after 300 thermal cycles.	Water	133-138	centromere protein V	Homo sapiens	37-41
2752025-4	1989	In these crystalline PS-Mg2+ complexes the phosphate group loses its water of hydration but the serine carboxylate remains hydrated.	Water	69-74	mucin 7, secreted	Homo sapiens	24-27
2617452-3	1989	Twitch Pdi during bilateral phrenic nerve stimulation ranged from 8.8 to 33 cm H2O in the control subjects and from 3.1 to 27 cm H2O in the 10 patients in whom a measurement could be obtained.	Water	79-82	prolyl 4-hydroxylase subunit beta	Homo sapiens	7-10
2533454-1	1989	The aim of this study was to investigate if atrial natriuretic peptide (ANP) plays a role in the control of water balance in goats and whether ANP affects the increase in mean arterial blood pressure (MAP) which accompanies drinking in water-deprived animals.	Water	108-113	natriuretic peptides A	Capra hircus	72-75
2546496-0	1989	Catalytic activity of cytochrome oxidase and cytochrome c in apolar solvents containing phospholipids and low amounts of water.	Water	121-126	LOC104968582	Bos taurus	45-57
2546496-3	1989	In the low water ternary system, cytochrome c could be reduced by ascorbate introduced via inverted micelles.	Water	11-16	LOC104968582	Bos taurus	33-45
2669838-4	1989	It is concluded that (a) brain ANG receptors for water and saline intakes are more accessible from the forebrain than the hindbrain ventricles and (b) receptors for water drinking, but not saline intake, after captopril reside in part in the SFO.	Water	49-54	angiogenin	Homo sapiens	31-34
2669838-4	1989	It is concluded that (a) brain ANG receptors for water and saline intakes are more accessible from the forebrain than the hindbrain ventricles and (b) receptors for water drinking, but not saline intake, after captopril reside in part in the SFO.	Water	165-170	angiogenin	Homo sapiens	31-34
2777275-3	1989	A colchicine bovine serum albumin (Col-BSA) conjugate, prepared using a water soluble carbodiimide coupling technique, formed the basis of an enzyme linked immunosorbent assay used for screening hybridomas for colchicine specific antibody secretion and for determining the relative affinity and specificity profile of the monoclonal antibodies.	Water	72-77	albumin	Mus musculus	20-33
2746239-1	1989	Prolonged intake of low levels of aluminum from the drinking water has been found to increase the aluminum content in rat brain homogenates and to reduce the activity of hexokinase and glucose-6-phosphate dehydrogenase (G6PD).	Water	61-66	glucose-6-phosphate dehydrogenase	Rattus norvegicus	185-218
2746239-1	1989	Prolonged intake of low levels of aluminum from the drinking water has been found to increase the aluminum content in rat brain homogenates and to reduce the activity of hexokinase and glucose-6-phosphate dehydrogenase (G6PD).	Water	61-66	glucose-6-phosphate dehydrogenase	Rattus norvegicus	220-224
2502682-0	1989	Role of Ca2+ and Mg2+ for endothelial permeability of water and albumin in vitro.	Water	54-59	mucin 7, secreted	Homo sapiens	17-20
2585755-2	1989	Legionella spp., the causative organism of legionnaires" disease, were isolated from more than 80% of water samples in cooling towers before washing.	Water	102-107	histocompatibility minor 13	Homo sapiens	11-14
2521797-4	1989	20 A from the lipid/water interface suggesting that the Ca2+ binding sites on the ATPase are also 20 A from the lipid/water interface.	Water	20-25	dynein axonemal heavy chain 8	Homo sapiens	82-88
2521797-4	1989	20 A from the lipid/water interface suggesting that the Ca2+ binding sites on the ATPase are also 20 A from the lipid/water interface.	Water	118-123	dynein axonemal heavy chain 8	Homo sapiens	82-88
11537376-5	1989	The reaction of the 5"-AMP with water soluble  carbodiimide in the presence of Na(+)-montmorillonite results in the formation of 2",5"-pApA (18.9%), 3",5"-pApA (11%), and AppA (4.8%).	Water	32-37	pappalysin 1	Homo sapiens	135-139
11537376-5	1989	The reaction of the 5"-AMP with water soluble  carbodiimide in the presence of Na(+)-montmorillonite results in the formation of 2",5"-pApA (18.9%), 3",5"-pApA (11%), and AppA (4.8%).	Water	32-37	pappalysin 1	Homo sapiens	155-159
2664120-6	1989	The type-specific polysaccharide of B-III-streptococci prepared by phenol-water extraction followed by gel-chromatography can be used as a screening antigen for the production of monoclonal antibodies against B-III-streptococci.	Water	74-79	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	36-41
2664120-6	1989	The type-specific polysaccharide of B-III-streptococci prepared by phenol-water extraction followed by gel-chromatography can be used as a screening antigen for the production of monoclonal antibodies against B-III-streptococci.	Water	74-79	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	209-214
18620263-6	1989	Estimates of the bound water content of tardigrades by DSC show that this can account for the dehydrated masses of these chloroform-rinsed animals and that all free water is probably transpired.	Water	23-28	desmocollin 3	Homo sapiens	55-58
2904771-8	1988	Our results suggest that an IAP substrate, probably Gi, 1) is required for signal transduction by renal alpha 2-adrenoceptors, 2) may tonically modulate the response to vasopressin in the CCT but not of parathyroid hormone in the proximal convoluted tubule, and 3) participates in renal water and electrolyte reabsorption independent of exogenous adenylate cyclase stimulation.	Water	287-292	Cd47 molecule	Rattus norvegicus	28-31
2850910-3	1988	Evidence from antibiotic MIC studies on porin-deficient mutants compared with their porin-sufficient parent strains has provided strong support for the proposal that some antibiotics, particularly beta-lactams, pass across the outer membrane through the water-filled channels of a class of proteins called porins.	Water	254-259	voltage dependent anion channel 1	Homo sapiens	40-45
2850910-3	1988	Evidence from antibiotic MIC studies on porin-deficient mutants compared with their porin-sufficient parent strains has provided strong support for the proposal that some antibiotics, particularly beta-lactams, pass across the outer membrane through the water-filled channels of a class of proteins called porins.	Water	254-259	voltage dependent anion channel 1	Homo sapiens	84-89
3287209-5	1988	Renin (5 mU), injected into the preoptic area, elicited a marked increase in the intake of water and salt, which lasted for about 3 days.	Water	91-96	renin	Rattus norvegicus	0-5
3362292-5	1988	Conjugase was semi-purified 24 fold in H2O and found to have a pH optimum of 5.0.	Water	39-42	gamma-glutamyl hydrolase	Rattus norvegicus	0-9
3415433-5	1988	Water-soluble nitrosoureas induce significant less inhibition of glutathione reductase as compared with established compounds.	Water	0-5	glutathione-disulfide reductase	Homo sapiens	65-86
3178784-2	1988	One hour after tetanization (electrical stimulation of area dentata granular cells and recording from CA3 pyramids) an inverse translocation of these Ca++-binding proteins was observed: an increase in the calmodulin content in the water-soluble and a decrease in the Lubrol-soluble fractions, while an increase in S-100 protein in the Triton-soluble and a decrease in the water-soluble fractions occurred.	Water	231-236	calmodulin 1	Rattus norvegicus	205-215
3178784-2	1988	One hour after tetanization (electrical stimulation of area dentata granular cells and recording from CA3 pyramids) an inverse translocation of these Ca++-binding proteins was observed: an increase in the calmodulin content in the water-soluble and a decrease in the Lubrol-soluble fractions, while an increase in S-100 protein in the Triton-soluble and a decrease in the water-soluble fractions occurred.	Water	372-377	calmodulin 1	Rattus norvegicus	205-215
3163519-6	1988	It was also observed that the presence of lauryl sulfate increased the solubility of CaF2 in water.	Water	93-98	CCR4-NOT transcription complex subunit 8	Homo sapiens	85-89
3335285-1	1988	Peptide YY inhibits the pancreatic exocrine secretion (bicarbonate, water, and protein) that is stimulated by cholecystokinin, secretin, or neurotensin in the dog, but whether peptide YY inhibits the release of gut peptides that stimulate pancreatic exocrine secretion is not known.	Water	68-73	peptide YY	Canis lupus familiaris	0-10
2827759-5	1987	These probes, as well as a benzaldehyde analogue of phosphatidic acid, and a water-soluble benzaldehyde reagent were covalently attached to bovine heart cytochrome c oxidase.	Water	77-82	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	153-173
3320348-5	1987	Nonopioid compounds, such as d-amphetamine, pentobarbital, phencyclidine and (+)-SKF 10,047 produced responding predominantly on the water-appropriate key in both U50,488- and morphine-trained pigeons.	Water	133-138	small nucleolar RNA, C/D box 50B	Homo sapiens	163-166
3032717-6	1987	Simultaneous feeding of sorbinil to inhibit aldose reductase resulted in normalization of both total nerve water and of the prolongation of T1 relaxation time.	Water	107-112	aldo-keto reductase family 1 member B1	Rattus norvegicus	44-60
3032951-7	1987	ATP triggers a conformational change on the water-exposed surface of cytochrome c oxidase; in this process, carboxyl groups forming the cluster of negative charges responsible for binding cytochrome c change their accessibility to water-soluble protein modifier reagents; as a consequence the electrostatic field that controls the enzyme-substrate interaction is altered and cytochrome c appears to bind differently to oxidase; photolabeling experiments with the enzyme from bovine heart and other eukaryotic sources show that ATP cross-links specifically to the cytoplasmic subunits IV and VIII.	Water	44-49	LOC104968582	Bos taurus	69-81
3032951-7	1987	ATP triggers a conformational change on the water-exposed surface of cytochrome c oxidase; in this process, carboxyl groups forming the cluster of negative charges responsible for binding cytochrome c change their accessibility to water-soluble protein modifier reagents; as a consequence the electrostatic field that controls the enzyme-substrate interaction is altered and cytochrome c appears to bind differently to oxidase; photolabeling experiments with the enzyme from bovine heart and other eukaryotic sources show that ATP cross-links specifically to the cytoplasmic subunits IV and VIII.	Water	44-49	LOC104968582	Bos taurus	188-200
3032951-7	1987	ATP triggers a conformational change on the water-exposed surface of cytochrome c oxidase; in this process, carboxyl groups forming the cluster of negative charges responsible for binding cytochrome c change their accessibility to water-soluble protein modifier reagents; as a consequence the electrostatic field that controls the enzyme-substrate interaction is altered and cytochrome c appears to bind differently to oxidase; photolabeling experiments with the enzyme from bovine heart and other eukaryotic sources show that ATP cross-links specifically to the cytoplasmic subunits IV and VIII.	Water	44-49	LOC104968582	Bos taurus	188-200
3032951-7	1987	ATP triggers a conformational change on the water-exposed surface of cytochrome c oxidase; in this process, carboxyl groups forming the cluster of negative charges responsible for binding cytochrome c change their accessibility to water-soluble protein modifier reagents; as a consequence the electrostatic field that controls the enzyme-substrate interaction is altered and cytochrome c appears to bind differently to oxidase; photolabeling experiments with the enzyme from bovine heart and other eukaryotic sources show that ATP cross-links specifically to the cytoplasmic subunits IV and VIII.	Water	231-236	LOC104968582	Bos taurus	69-81
3032951-7	1987	ATP triggers a conformational change on the water-exposed surface of cytochrome c oxidase; in this process, carboxyl groups forming the cluster of negative charges responsible for binding cytochrome c change their accessibility to water-soluble protein modifier reagents; as a consequence the electrostatic field that controls the enzyme-substrate interaction is altered and cytochrome c appears to bind differently to oxidase; photolabeling experiments with the enzyme from bovine heart and other eukaryotic sources show that ATP cross-links specifically to the cytoplasmic subunits IV and VIII.	Water	231-236	LOC104968582	Bos taurus	188-200
3032951-7	1987	ATP triggers a conformational change on the water-exposed surface of cytochrome c oxidase; in this process, carboxyl groups forming the cluster of negative charges responsible for binding cytochrome c change their accessibility to water-soluble protein modifier reagents; as a consequence the electrostatic field that controls the enzyme-substrate interaction is altered and cytochrome c appears to bind differently to oxidase; photolabeling experiments with the enzyme from bovine heart and other eukaryotic sources show that ATP cross-links specifically to the cytoplasmic subunits IV and VIII.	Water	231-236	LOC104968582	Bos taurus	188-200
3576008-1	1987	Crude extracts obtained by water extraction from the muscle of an ascidian (Halocynthia rotezi) are shown to possess an inhibitory activity on ATPase [(Na, K) ATPase, TF1-ATPase, HMM-ATPase].	Water	27-32	dynein axonemal heavy chain 8	Homo sapiens	143-149
3576008-1	1987	Crude extracts obtained by water extraction from the muscle of an ascidian (Halocynthia rotezi) are shown to possess an inhibitory activity on ATPase [(Na, K) ATPase, TF1-ATPase, HMM-ATPase].	Water	27-32	dynein axonemal heavy chain 8	Homo sapiens	159-165
3576008-1	1987	Crude extracts obtained by water extraction from the muscle of an ascidian (Halocynthia rotezi) are shown to possess an inhibitory activity on ATPase [(Na, K) ATPase, TF1-ATPase, HMM-ATPase].	Water	27-32	dynein axonemal heavy chain 8	Homo sapiens	159-165
3576008-1	1987	Crude extracts obtained by water extraction from the muscle of an ascidian (Halocynthia rotezi) are shown to possess an inhibitory activity on ATPase [(Na, K) ATPase, TF1-ATPase, HMM-ATPase].	Water	27-32	dynein axonemal heavy chain 8	Homo sapiens	159-165
3822822-7	1987	Results from high resolution mass spectrometry and 1H NMR indicate that the new photoproduct comprises a mixture of two stereoisomers whose formation involves covalent coupling of the adenine bases in d(ApA) and concomitant incorporation of the elements of one molecule of water.	Water	273-278	glutamyl aminopeptidase	Homo sapiens	203-206
3791245-6	1987	The finding of 4-ABP adducts in all nonsmokers was not anticipated but is consistent with low-level ubiquitous contamination of air, food, or water.	Water	142-147	amine oxidase copper containing 1	Homo sapiens	17-20
3618265-6	1987	Water loss distribution in relation to total water loss during control exercise was as follows: (Ediff + Eres) 14.8% (Esk) 59.6%; and (mdrip) 25.6%.	Water	0-5	TTK protein kinase	Homo sapiens	118-121
3794390-6	1987	Wide interindividual variation was observed in basal cytochrome P-450-dependent aryl hydrocarbon hydroxylase (AHH) activity which ranged from 0.6-17.6 fmol water-soluble BP metabolites/h/hair follicle (mean +/- SE of 32 individuals was 9.7 +/- 0.9).	Water	156-161	aryl hydrocarbon receptor repressor	Homo sapiens	110-113
3561338-4	1987	In the case of dual energy scanning, the error arises because when normalized to that of water, the mass attenuation coefficient of fat increases with photon energy while the reverse is true for K2HPO4.	Water	89-94	FAT atypical cadherin 1	Homo sapiens	132-135
3574489-5	1987	Dialysis of such homogenates for 4 h in distilled water at 37 degrees C (but not at 13 degrees C) led to a complete return of the MAO activity.	Water	50-55	monoamine oxidase A	Rattus norvegicus	130-133
3574489-9	1987	In brain homogenates prepared in, and dialysed against, distilled water or KRB at 37 degrees C (but not at 13 degrees C), MAO-A inhibited by moclobemide (100-300 mumol/kg) to approx.	Water	66-71	monoamine oxidase A	Rattus norvegicus	122-127
3628547-1	1987	Calcitonin suppresses food and water intake.	Water	31-36	calcitonin-related polypeptide alpha	Rattus norvegicus	0-10
3628548-1	1987	Evidence indicates that intra-third cerebroventricular (III-ICV) administration of calcitonin suppresses food and water intake of rats.	Water	114-119	calcitonin-related polypeptide alpha	Rattus norvegicus	83-93
3628548-3	1987	Administration of calcitonin (0.5 U/rat) suppressed food and water intake in male Wistar rats.	Water	61-66	calcitonin-related polypeptide alpha	Rattus norvegicus	18-28
3628548-6	1987	The results suggest that decrease in water intake by III-ICV calcitonin may be a consequence of the food intake suppression, i.e., reduced prandial drinking.	Water	37-42	calcitonin-related polypeptide alpha	Rattus norvegicus	61-71
3800385-5	1986	When the apparent Km for ATP of CKm was estimated by measuring creatine phosphate synthesis, the values obtained using water-treated mitochondria (0.21 mM) were slightly higher than those of intact mitochondria (0.12 mM) but the difference was not significant.	Water	119-124	creatine kinase M-type	Oryctolagus cuniculus	32-35
2948559-8	1986	50% of the tryptophan residues of the ATPase are located close to the lipid-water interface of the membrane.	Water	76-81	dynein axonemal heavy chain 8	Homo sapiens	38-44
3021771-2	1986	To specifically characterize the molecular identity of the high affinity site and to compare it with the low affinity site, the water-soluble carbodiimide EDC was used to cross-link 125I-NGF to NGF receptors on: rat PC12 cells, PC12nnr5 cells (PC12 mutants that have only low affinity NGF binding), SH-SY5Y human neuroblastoma cells (which have only high affinity binding sites), and cultured rat sympathetic ganglion cells.	Water	128-133	nerve growth factor	Rattus norvegicus	187-190
3021771-2	1986	To specifically characterize the molecular identity of the high affinity site and to compare it with the low affinity site, the water-soluble carbodiimide EDC was used to cross-link 125I-NGF to NGF receptors on: rat PC12 cells, PC12nnr5 cells (PC12 mutants that have only low affinity NGF binding), SH-SY5Y human neuroblastoma cells (which have only high affinity binding sites), and cultured rat sympathetic ganglion cells.	Water	128-133	nerve growth factor	Rattus norvegicus	194-197
3021771-2	1986	To specifically characterize the molecular identity of the high affinity site and to compare it with the low affinity site, the water-soluble carbodiimide EDC was used to cross-link 125I-NGF to NGF receptors on: rat PC12 cells, PC12nnr5 cells (PC12 mutants that have only low affinity NGF binding), SH-SY5Y human neuroblastoma cells (which have only high affinity binding sites), and cultured rat sympathetic ganglion cells.	Water	128-133	nerve growth factor	Rattus norvegicus	194-197
2439047-1	1986	Porcine follicular fluid has been shown to have a specific water-soluble receptor for human chorionic gonadotropin (hCG).	Water	59-64	chorionic gonadotropin subunit beta 5	Homo sapiens	92-120
3803465-4	1986	After intracameral injection of 1 microgram VIP, the outflow facility was higher in the experimental eye than in the control; 0.42 +/- 0.46 compared with 0.33 +/- 0.03 microliter cm H20-1 min-1, difference 0.09 +/- 0.04 microliter cm H2O-1 min-1.	Water	234-237	VIP peptides	Oryctolagus cuniculus	44-47
2428399-1	1986	A purified (Na+ + K+)-ATPase large subunit obtained from microsomes by water-alcohol extraction was incorporated into a bilayer lipid membrane.	Water	71-76	dynein axonemal heavy chain 8	Homo sapiens	22-28
3790520-7	1986	Similarly, there was an increase in protein C23 extracted into the water layer after irradiation.	Water	67-72	nucleolin	Homo sapiens	44-47
3745178-5	1986	The results for interfacial lipoprotein lipase catalysis, along with previously determined kinetic parameters for the water-soluble esters p-nitrophenyl acetate and p-nitrophenyl butyrate, indicate that lipoprotein lipase has highest specificity for the substrates that have fatty acyl chains of intermediate length (i.e. p-nitrophenyl butyrate and p-nitrophenyl caprylate).	Water	118-123	lipoprotein lipase	Bos taurus	203-221
3518497-3	1986	Although plasma Na+ concentration, osmolality, and hematocrit of dehydrated rats had returned to control replete levels by 2-4 h after the return of water, the plasma renin and angiotensin II levels exhibited a further increase on rehydration and remained significantly above dehydration levels for 2-4 h after the return of water.	Water	325-330	renin	Rattus norvegicus	167-191
3717543-11	1986	From the literature it is known that beta 2-mimetics can aggravate the increased water and sodium retention during pregnancy and cause pulmonary edema by an additional increase in pulmonary artery pressure.	Water	81-86	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	37-43
3516179-6	1986	Evidence for this suggestion has been gathered from studies of the myelin basic protein, a water-soluble protein with a number of hydrophobic residues.	Water	91-96	myelin basic protein	Homo sapiens	67-87
2431896-0	1986	Electrostatic lock-and-key model for the study of biological isosterism: role of structural water in the binding of basic pancreatic trypsin inhibitor to beta-trypsin.	Water	92-97	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	133-150
2431896-0	1986	Electrostatic lock-and-key model for the study of biological isosterism: role of structural water in the binding of basic pancreatic trypsin inhibitor to beta-trypsin.	Water	92-97	serine protease 1	Homo sapiens	154-166
2811618-3	1989	Good correlation is found between the fat and water content measured by imaging and that measured by other means except for the inability to differentiate unsaturated fat protons from water protons.	Water	46-51	FAT atypical cadherin 1	Homo sapiens	38-41
2811618-4	1989	Longitudinal (T1) and transverse (T2) relaxation times for water and fat are also shown to be measurable independently when fat and water signal are suppressed accordingly.	Water	59-64	FAT atypical cadherin 1	Homo sapiens	124-127
2811618-4	1989	Longitudinal (T1) and transverse (T2) relaxation times for water and fat are also shown to be measurable independently when fat and water signal are suppressed accordingly.	Water	132-137	FAT atypical cadherin 1	Homo sapiens	69-72
2660910-1	1989	The enzyme activity of glutathione reductase (NAD(P)H:oxidized-glutathione oxidoreductase, EC 1.6.4.2) incorporated in CTAB/H2O/CHCl3-isooctane (1:1, v/v) reverse micelles has been investigated.	Water	124-127	glutathione-disulfide reductase	Homo sapiens	23-44
2513789-8	1989	After beta-glucuronidase cleavage, 80% to 95% of the water soluble derivatives were released as free steroids.	Water	53-58	glucuronidase beta	Homo sapiens	6-24
2703526-5	1989	Incorporation of tritiated water into fatty acids in the liver was increased 45% 1-2 h after TNF and 87% at 16-17 h. These results indicate that the TNF-induced increase in circulating lipid levels can occur in the absence of a TNF-induced inhibition of adipose tissue lipoprotein lipase activity.	Water	27-32	tumor necrosis factor-like	Rattus norvegicus	93-96
2703526-5	1989	Incorporation of tritiated water into fatty acids in the liver was increased 45% 1-2 h after TNF and 87% at 16-17 h. These results indicate that the TNF-induced increase in circulating lipid levels can occur in the absence of a TNF-induced inhibition of adipose tissue lipoprotein lipase activity.	Water	27-32	tumor necrosis factor-like	Rattus norvegicus	149-152
2703526-5	1989	Incorporation of tritiated water into fatty acids in the liver was increased 45% 1-2 h after TNF and 87% at 16-17 h. These results indicate that the TNF-induced increase in circulating lipid levels can occur in the absence of a TNF-induced inhibition of adipose tissue lipoprotein lipase activity.	Water	27-32	tumor necrosis factor-like	Rattus norvegicus	149-152
2710002-1	1989	We propose a family of hybrid chemical-shift sequences which combines two physical principles for water/lipid separation to minimize artifacts introduced by B0 and B1 inhomogeneities.	Water	98-103	CD80 molecule	Homo sapiens	157-166
2483074-4	1989	Both main-stream and side-stream cigarette smoke condensates and some fractions, containing water-soluble bases, water-insoluble bases, and polycyclic aromatic hydrocarbons, were found to induce AHH activity in lung and liver, the lung being induced to the greatest extent.	Water	92-97	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	195-198
2720108-1	1989	Leucine-enkephalin (Try1-Gly2-Gly3-Phe4-Leu5) has been crystallized as a trihydrate from water solution.	Water	89-94	serine protease 1	Homo sapiens	20-24
3239782-2	1988	Cellooligomers (DP3-DP8) can be isolated by high-resolution size-exclusion chromatography on Bio-Gel P 4 using water as eluent.	Water	111-116	APC regulator of WNT signaling pathway	Homo sapiens	16-23
3180089-4	1988	Photoinactivation of acetylcholinesterase was the same in D2O as in H2O and was not quenched by superoxide dismutase.	Water	68-71	acetylcholinesterase	Mus musculus	21-41
3203685-3	1988	Besides this Cys72, proteinase K has two disulfide bonds, Cys34--Cys123 and Cys178--Cys249, which contribute to the stability of the tertiary structure consisting of an extended central parallel beta-sheet decorated by six alpha-helices, three short antiparallel beta-sheets, 18 beta-turns and involving several internal, structurally important water molecules.	Water	345-350	endogenous retrovirus group K member 7	Homo sapiens	20-30
3203685-10	1988	Based on these experiments, a reaction mechanism is proposed where the peptide substrate forms a three-stranded antiparallel pleated sheet with the recognition site of proteinase K consisting of Ser132--Leu133--Gly134 on one side and Gly100--Ser101 on the other, followed by expulsion of the oxyanion hole water W335 and hydrolytic cleavage by the Asp39--His69--Serr224 triad.	Water	306-311	endogenous retrovirus group K member 7	Homo sapiens	168-178
2976327-8	1988	The administration of ANP (2 micrograms/kg bodyweight) to rabbits in water diuresis did not alter systemic blood pressure but induced a marked natriuresis and increases in urine flow and potassium excretion.	Water	69-74	natriuretic peptides A	Oryctolagus cuniculus	22-25
3069523-7	1988	63-75) we showed that thirst elicited by activation of the brain"s renin-angiotensin system in the suckling becomes specific to water after 16 days of age.	Water	128-133	renin	Rattus norvegicus	67-72
2855257-5	1988	The estimations of the values K1 and K2 in water-alcohol mixtures and in aqueous micellar solutions of surfactant together with kinetical and spectral data show that the increase of K1 and K2 in reversed micelles is caused generally by redox potential changes of low-molecular reagents.	Water	43-48	keratin 1	Homo sapiens	30-39
2855257-5	1988	The estimations of the values K1 and K2 in water-alcohol mixtures and in aqueous micellar solutions of surfactant together with kinetical and spectral data show that the increase of K1 and K2 in reversed micelles is caused generally by redox potential changes of low-molecular reagents.	Water	43-48	keratin 1	Homo sapiens	182-191
2844852-10	1988	These results suggest that EGF can modulate both salt and water transport in the CCT via a receptor linked to protein kinase C activation.	Water	58-63	pro-epidermal growth factor	Oryctolagus cuniculus	27-30
2845965-1	1988	The steady-state kinetics of ubiquinol cytochrome c reductase was investigated in submitochondrial particles using ubiquinol-1 as electron donor in media of increasing viscosities obtained by water-polyethylene glycol mixtures.	Water	192-197	LOC104968582	Bos taurus	39-51
3415847-3	1988	Lipase production was assayed using water-insoluble substrates (radiolabelled triglyceride emulsions).	Water	36-41	lipase	Staphylococcus aureus	0-6
2899463-9	1988	The results suggest that high circulating atrial natriuretic peptide levels may prevent or limit salt and water retention, either directly or indirectly, by inhibiting the renin-angiotensin-aldosterone system.	Water	106-111	renin	Rattus norvegicus	172-177
3203921-0	1988	[Experimental substantiation of maximum permissible levels of DPF-1 and DPF-1N in reservoir water].	Water	92-97	double PHD fingers 1	Homo sapiens	62-67
3138476-0	1988	[Thyrotropin-releasing hormone levels under water-immersion stress in rats].	Water	44-49	thyrotropin releasing hormone	Rattus norvegicus	1-30
2897232-6	1988	The activity of TH in the SCG of animals that drank 10 mM, 30 mM, and 100 mM NaCl was 143 +/- 24, 167 +/- 12, and 272 +/- 13 mol DOPA.h-1.mol TH-1, respectively, compared to 119 +/- 10 for animals that drank water.	Water	208-213	tyrosine hydroxylase	Rattus norvegicus	16-18
2897232-8	1988	In animals that drank water, 10 mM, 30 mM, and 100 mM NaCl, the amounts (pmol) of TH were, respectively, 0.28 +/- 0.03, 0.31 +/- 0.04, 0.23 +/- 0.02, and 0.21 +/- 0.01 per ME and 0.67 +/- 0.06, 0.72 +/- 0.11, 0.37 +/- 0.01, and 0.34 +/- 0.02 per SCG.	Water	22-27	tyrosine hydroxylase	Rattus norvegicus	82-84
3128444-9	1988	Our results strongly support the hypothesis that the rate-limiting step in CO2 hydration catalyzed by carbonic anhydrase III is the protolysis of metal-bound water.	Water	158-163	carbonic anhydrase 3	Bos taurus	102-124
2966640-4	1988	ATPase derivatization with [14C]DCCD under mild conditions produced selective inhibition of ATPase hydrolytic catalysis (EP + H2O in equilibrium E + Pi) without significant incorporation of the 14C radioactive label.	Water	126-129	dynein axonemal heavy chain 8	Homo sapiens	0-6
2966640-4	1988	ATPase derivatization with [14C]DCCD under mild conditions produced selective inhibition of ATPase hydrolytic catalysis (EP + H2O in equilibrium E + Pi) without significant incorporation of the 14C radioactive label.	Water	126-129	dynein axonemal heavy chain 8	Homo sapiens	92-98
3287209-0	1988	Gamma-aminobutyric acid and taurine antagonize the central effects of angiotensin II and renin on the intake of water and salt, and on blood pressure in rats.	Water	112-117	renin	Rattus norvegicus	89-94
2434771-4	1986	Inhibition of the renin-angiotensin system following administration of d(CH2)5DAVP causes a greater hypotension in PEG-treated than in water-deprived Long-Evans rats.	Water	135-140	renin	Rattus norvegicus	18-23
4074780-3	1985	It was shown that in uncoupled reactions cytochrome P-450, besides O2- generation catalyzes direct two- and four-electron reduction of O2 to produce H2O2 and water, respectively.	Water	158-163	cytochrome P-450	Oryctolagus cuniculus	41-57
2684960-6	1989	A region of the amino acid sequence of Pol I (peptide I) consisting of residues 728-777 has been synthesized and found to contain significant secondary structure by CD both in water and 50% methanol/water.	Water	176-181	DNA polymerase iota	Homo sapiens	39-44
4086944-3	1985	In intestine and liver, however, large amounts of rac-1-O-[1"-14C]dodecylglycerol were catabolized by oxidative cleavage of the ether bond followed by degradation of the radioactive cleavage product, i.e., lauric acid, to water-soluble metabolites that were excreted in the urine at a fast rate.	Water	222-227	Rac family small GTPase 1	Mus musculus	50-55
2446664-2	1988	Although myelin basic protein is a water soluble protein which binds electrostatically only to acidic lipids, unlike polylysine it has several short hydrophobic regions.	Water	35-40	myelin basic protein	Homo sapiens	9-29
3364244-6	1988	By comparing the measured reaction rates of O2 and CO with the theoretical rates obtained from the numerical solutions of the partial differential equations of the diffusions of O2 and CO, the transfer coefficients of O2 and CO (eta O2 and eta CO) in the RBC boundary, including the RBC membrane and water layer around the RBC, were estimated.	Water	300-305	endothelin receptor type A	Homo sapiens	229-232
2684960-6	1989	A region of the amino acid sequence of Pol I (peptide I) consisting of residues 728-777 has been synthesized and found to contain significant secondary structure by CD both in water and 50% methanol/water.	Water	199-204	DNA polymerase iota	Homo sapiens	39-44
2812055-0	1989	Why the need for LAL testing in water treatment?	Water	32-37	lipase A, lysosomal acid type	Homo sapiens	17-20
3276572-1	1988	Renin (1 ng) was injected into the 3rd ventricle of the brain of rat pups at various ages, and their ingestion was measured by weighing them either after 40 min of oral infusion of water or milk while they were away from their dam (off-dam), or after 40 min of suckling from their dams (on-dam).	Water	181-186	renin	Rattus norvegicus	0-5
3276572-5	1988	These findings reveal that the adult characteristics of the dipsogenic action of the renin-angiotensin system in the brain emerge at 15 days, at which age the increased intake becomes entirely specific for water.	Water	206-211	renin	Rattus norvegicus	85-90
2994494-1	1985	Parathyroid hormone (PTH), through the generation of cAMP, inhibits the transport of sodium, bicarbonate, and water in the proximal convoluted tubule.	Water	110-115	parathyroid hormone	Oryctolagus cuniculus	0-19
2994494-1	1985	Parathyroid hormone (PTH), through the generation of cAMP, inhibits the transport of sodium, bicarbonate, and water in the proximal convoluted tubule.	Water	110-115	parathyroid hormone	Oryctolagus cuniculus	21-24
2819035-5	1989	The comparison of substrate specificity among beta beta isoenzymes for primary straight-chain alcohols indicates that there is a positive correlation between Vmax/KM and the log octanol/water partition coefficient for alcohols with beta 2 beta 2 and beta 3 beta 3 but not with beta 1 beta 1.	Water	186-191	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	232-238
3876134-3	1985	rCBF was measured when the external auditory meatus was irrigated with water at body temperature as a control to vestibular stimulation.	Water	71-76	CCAAT/enhancer binding protein zeta	Rattus norvegicus	0-4
2835132-5	1987	The low cardiovascular activity of NKB cannot be attributed to its hydrophobicity, as the water soluble analogue of NKB, [Arg0]NKB, elicits a response as weak as the native peptide.	Water	90-95	tachykinin precursor 3	Rattus norvegicus	35-38
2835132-5	1987	The low cardiovascular activity of NKB cannot be attributed to its hydrophobicity, as the water soluble analogue of NKB, [Arg0]NKB, elicits a response as weak as the native peptide.	Water	90-95	tachykinin precursor 3	Rattus norvegicus	116-119
2835132-5	1987	The low cardiovascular activity of NKB cannot be attributed to its hydrophobicity, as the water soluble analogue of NKB, [Arg0]NKB, elicits a response as weak as the native peptide.	Water	90-95	tachykinin precursor 3	Rattus norvegicus	116-119
3995064-1	1985	Diethyl-p-nitrophenyl phosphate is an active site-directed irreversible inhibitor of bovine milk lipoprotein lipase catalyzed hydrolysis of the water-soluble substrate, p-nitrophenyl butyrate.	Water	144-149	lipoprotein lipase	Bos taurus	97-115
2819035-5	1989	The comparison of substrate specificity among beta beta isoenzymes for primary straight-chain alcohols indicates that there is a positive correlation between Vmax/KM and the log octanol/water partition coefficient for alcohols with beta 2 beta 2 and beta 3 beta 3 but not with beta 1 beta 1.	Water	186-191	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	239-245
3308700-2	1987	Renin injected into the preoptic area increased water intake and evoked salt (2.7% NaCl solution) intake, and angiotensin II injected into this area increased water intake, but not salt intake, in both SHR and control normotensive Wistar-Kyoto rats (WKY).	Water	48-53	renin	Rattus norvegicus	0-5
2671515-5	1989	Renin injections by either procedure evoked copious drinking of water (224 +/- 23 ml/24 h) and 3% NaCl (44 +/- 9.1 ml/24 h) at smaller doses than previously reported.	Water	64-69	renin	Rattus norvegicus	0-5
3983096-6	1985	Thyroglobulin was iodinated with KI + I2 water solution, pH 9.2, at 37 C for 30 min.	Water	41-46	thyroglobulin	Homo sapiens	0-13
3631310-3	1987	In the presence of food, NPY caused enhancement of water intake, whereas in the absence of food, NPY suppressed water intake.	Water	51-56	neuropeptide Y	Mus musculus	25-28
2780515-13	1989	Both alcohol/water and water extracted adrenal inhibited hCG secretion.	Water	13-18	hypertrichosis 2 (generalised, congenital)	Homo sapiens	57-60
3631310-3	1987	In the presence of food, NPY caused enhancement of water intake, whereas in the absence of food, NPY suppressed water intake.	Water	112-117	neuropeptide Y	Mus musculus	97-100
6518370-4	1984	In vivo, lead exposure through drinking water enhances [3H]NDP binding to crude synaptosomal membrane preparations.	Water	40-45	norrin cystine knot growth factor NDP	Rattus norvegicus	59-62
2780515-13	1989	Both alcohol/water and water extracted adrenal inhibited hCG secretion.	Water	23-28	hypertrichosis 2 (generalised, congenital)	Homo sapiens	57-60
2960520-1	1987	The specific recognition by mitochondria of the precursor of porin and the insertion into the outer membrane were studied with a radiolabeled water-soluble form of porin derived from the mature protein.	Water	142-147	voltage dependent anion channel 1	Homo sapiens	164-169
2960520-6	1987	Water-soluble porin competed for the specific binding and import of the precursor of the ADP/ATP carrier, an inner membrane protein.	Water	0-5	voltage dependent anion channel 1	Homo sapiens	14-19
2787509-6	1989	They are absent from other vasotocin-bearers such as birds and could be involved specifically in water-electrolyte regulation of amphibians.	Water	97-102	arginine vasopressin S homeolog	Xenopus laevis	27-36
3663605-2	1987	Water proton relaxation rates of various complexes of cholesterol side chain cleavage cytochrome P-450 (-450scc) were investigated to gain information about the structure and dynamics of the steroid binding site.	Water	0-5	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	97-111
6512726-2	1984	Without prior exposure to reducing conditions, a high percent excysted after incubation in a mixture of trypsin and bile salts in Ringer"s solution; fewer excysted after incubation in tap water, even fewer after incubation in salt solutions, and none after incubation in saliva.	Water	188-193	tracheal antimicrobial peptide	Bos taurus	184-187
6480586-5	1984	Plots of 1/fluorescence versus T/eta yield straight lines for both alcohols and glycerol/water mixtures.	Water	89-94	endothelin receptor type A	Homo sapiens	33-36
2472293-1	1989	Negatively charged carboxyl groups of mitochondrial porin have been converted into positively charged ones by means of reaction with water-soluble carbodiimide in the presence of ethylenediamine.	Water	133-138	voltage dependent anion channel 1	Homo sapiens	52-57
6470051-1	1984	Positron emission tomographic (PET) measurements of regional cerebral blood flow (rCBF) with intravenously administered 15O-labeled water and an adaptation of the Kety autoradiographic model are well suited to the study of functional-anatomical correlations within the human brain.	Water	132-137	CCAAT/enhancer binding protein zeta	Rattus norvegicus	82-86
3662051-5	1987	Two forms of diaphorase were found-water-soluble and Triton X-100 soluble, showing low activity-0.36 U/ml and 0.26 U/ml.	Water	35-40	dihydrolipoamide dehydrogenase	Homo sapiens	13-23
3118602-6	1987	An explanation can be the structure of stomach mucous gel can be solubilized in water and thus the ions are liberized inside of the stomach mucin.	Water	80-85	LOC100508689	Homo sapiens	140-145
2713842-4	1989	Sprague-Dawley rats injected with TNF (250 micrograms/kg) show a significant decrease in weight over the next 24 h which can be accounted for by decreases in food and water intake accompanied by an increase in urine output.	Water	167-172	tumor necrosis factor-like	Rattus norvegicus	34-37
3610446-6	1987	The study results indicate that THM in Wisconsin drinking water does not pose a significant colon cancer risk.	Water	58-63	THM	Homo sapiens	32-35
6466700-2	1984	Hepatic triacylglycerol lipase (EC 3.1.1.3) hydrolyzes water-insoluble fatty acid esters, e.g., trioleoylglycerol (lipase activity) and water-soluble fatty acid esters, e.g., tributyrin (esterase activity).	Water	55-60	lipase C, hepatic type	Homo sapiens	0-30
2539284-0	1989	Intravenous calcitonin gene-related peptide stimulates net water secretion in rat colon in vivo.	Water	59-64	calcitonin-related polypeptide alpha	Rattus norvegicus	12-43
6466700-2	1984	Hepatic triacylglycerol lipase (EC 3.1.1.3) hydrolyzes water-insoluble fatty acid esters, e.g., trioleoylglycerol (lipase activity) and water-soluble fatty acid esters, e.g., tributyrin (esterase activity).	Water	136-141	lipase C, hepatic type	Homo sapiens	0-30
6725248-1	1984	The water-soluble carbodiimide, N-ethyl-3-(3-dimethylaminopropyl)carbodiimide was found to effectively cross-link ferredoxin to ferredoxin-NADP+ reductase.	Water	4-9	ferredoxin reductase	Homo sapiens	128-154
6724293-0	1984	Growth hormone and prolactin secretion in water-deprived chickens.	Water	42-47	growth hormone	Gallus gallus	0-14
6724293-3	1984	The deprivation of water had no effect on basal level of pituitary GH release in vitro but abolished the stimulatory effect of the hypothalamus on in vitro GH secretion.	Water	19-24	growth hormone	Gallus gallus	156-158
6699007-6	1984	From these results, we propose that Hg(II) reacts with the double bond between C-5 and C-6 to form a mercuronium ion which is opened by the nucleophilic attack of water on C-6.	Water	163-168	complement C6	Homo sapiens	87-90
6426767-2	1984	A mutant unable to make the lipoprotein (lpo) was extremely sensitive to freezing and thawing in water or saline and to challenge with detergent, while the mutant unable to make the porin proteins (ompB) was more resistant than the isogenic wild type; strains unable to make the tsx and ompA proteins were slightly more sensitive to the stresses.	Water	97-102	lipoprotein	Escherichia coli	28-39
6426767-2	1984	A mutant unable to make the lipoprotein (lpo) was extremely sensitive to freezing and thawing in water or saline and to challenge with detergent, while the mutant unable to make the porin proteins (ompB) was more resistant than the isogenic wild type; strains unable to make the tsx and ompA proteins were slightly more sensitive to the stresses.	Water	97-102	lipoprotein	Escherichia coli	41-44
6548205-1	1984	HbA2 Fitzroy is a new delta-chain variant with the amino acid substitution delta 142 (H2O) Ala----Asp.	Water	86-89	hemoglobin subunit alpha 2	Homo sapiens	0-4
6706914-1	1984	To determine the steric course of the reaction of bacterial ornithine decarboxylase [EC 4.1.1.17], we have carried out the decarboxylation of L-ornithine in 2H2O and that of DL-[2-2H]ornithine in H2O, and obtained putrescine bearing a single deuterium atom in the C-1 position.	Water	158-161	ornithine decarboxylase 1	Homo sapiens	60-83
6399313-3	1984	Increased circulating renin after captopril treatment in adrenalectomized rats (Elfont and Fitzsimons, 1981), or in renal hypertension following partial inter-renal aortic ligation (Costales et al., 1982), also leads to increased intakes of 2.7% NaCl and water.	Water	255-260	renin	Rattus norvegicus	22-27
6399315-11	1984	Its vasoconstrictive action on the efferent glomerular arteriole might enable the renin-angiotensin system to participate in the control of renal excretion of salt and water.	Water	168-173	renin	Rattus norvegicus	82-87
6708133-6	1984	Distribution of radioactivity content of CDP-choline among brain areas 10 min after its administration showed a noticeable enrichment of the nucleotide and water-soluble-related compounds in the examined areas, but to a lesser degree in the cerebral cortex.	Water	156-161	cut-like homeobox 1	Rattus norvegicus	41-44
6708133-8	1984	This last result is probably due to a dilution effect brought about by the administered cold CDP-choline upon the (14C)-containing water-soluble metabolites.	Water	131-136	cut-like homeobox 1	Rattus norvegicus	93-96
6382275-6	1984	Because of the frequent isolation of E coli in calcium bilirubinate stone cases, beta-glucuronidase from E coli has been thought to be responsible for the formation of calcium bilirubinate stones by effecting hydrolysis of bilirubin glucuronide to free bilirubin, which is insoluble in water.	Water	286-291	glucuronidase beta	Homo sapiens	81-99
6484515-0	1984	[Aeration of water as aid in water protection--the Teltow Canal example].	Water	13-18	activation induced cytidine deaminase	Homo sapiens	22-25
6484515-0	1984	[Aeration of water as aid in water protection--the Teltow Canal example].	Water	29-34	activation induced cytidine deaminase	Homo sapiens	22-25
6226318-5	1983	It was assumed that all the compounds tested influenced soluble ATPase by changing the nucleophilic activity of H2O.	Water	112-115	dynein, axonemal, heavy chain 8	Mus musculus	64-70
6344331-2	1983	Relative to time controls (TC), rats chronically exposed to 500 ppm lead in drinking water had significantly elevated basal plasma renin concentrations (PRC) (Pb = 12.0 +/- 1.6 ng/ml/hr, TC = 7.6 +/- 0.8).	Water	85-90	renin	Rattus norvegicus	131-136
6349938-2	1983	The volume loss due to water efflux was quantified optically for the cooling rates 2.4, 12, 48, and 120 degrees K/min.	Water	23-28	FANCD2 and FANCI associated nuclease 1	Homo sapiens	112-117
6348202-2	1983	Several authors have reported a reduction of the human myocardial Mg2+ content in areas with (Mg2+ poor) soft water, without a significant alteration of Mg2+ in serum or skeletal muscle.	Water	110-115	mucin 7, secreted	Homo sapiens	66-69
6348202-2	1983	Several authors have reported a reduction of the human myocardial Mg2+ content in areas with (Mg2+ poor) soft water, without a significant alteration of Mg2+ in serum or skeletal muscle.	Water	110-115	mucin 7, secreted	Homo sapiens	94-97
6348202-2	1983	Several authors have reported a reduction of the human myocardial Mg2+ content in areas with (Mg2+ poor) soft water, without a significant alteration of Mg2+ in serum or skeletal muscle.	Water	110-115	mucin 7, secreted	Homo sapiens	94-97
6854316-4	1983	Reaction with the form HL-2 (only the amino nitrogen protonated), the dominant form of this species, proceeds by the expected rat limiting water loss (dissociative or Eigen) mechanism with rate constants of 9.3 X 10(7) M-1 sec-1 (+/- 24%) for mono and 5.1 X 10(7) M-1 sec-1 (+/- 25%) for bis complex formation.	Water	139-144	asialoglycoprotein receptor 2	Rattus norvegicus	23-27
6348254-6	1983	A single preoptic injection of less than 0.75 pmol (26.5 ng) purified mouse renin caused mean intakes of 250.4 +/- 26.2 ml water and 44.8 +/- 12.5 ml 2.7% NaCl by five naive rats in 24 h. After the largest dose (265 ng) intakes of water and 2.7% NaCl reached about 80% and 20% body weight respectively.4.	Water	231-236	renin	Rattus norvegicus	76-81
6348254-7	1983	Weekly injections of renin resulted in progressively larger intakes of NaCl and water in response to the injections.5.	Water	80-85	renin	Rattus norvegicus	21-26
6348254-13	1983	Increased intakes of water and 2.7% NaCl caused by renin resulted in the rats going into and remaining in positive fluid and sodium balance throughout the 24 h experiment.8.	Water	21-26	renin	Rattus norvegicus	51-56
6342533-1	1983	Verification of membrane filter total coliform colonies from drinking water was increased 87% by testing for the presence of beta-galactosidase and cytochrome oxidase, compared with verification by determination of gas production in lauryl tryptose broth.	Water	70-75	galactosidase beta 1	Homo sapiens	125-143
6337511-6	1983	Plasma renin activity tended to increase as the length of the water-deprivation period increased.	Water	62-67	renin	Rattus norvegicus	7-12
6849393-9	1983	These alterations in motility with concomitant secretion of water and electrolytes may contribute to the diarrhea induced by VIP infusion.	Water	60-65	VIP peptides	Oryctolagus cuniculus	125-128
6297972-1	1982	Two water-soluble carbodiimides, differing in molecular dimensions, have been used to characterize the cytochrome c binding site of bovine heart cytochrome c oxidase.	Water	4-9	LOC104968582	Bos taurus	103-115
3114407-2	1987	A significant reduction in salt and water outputs, glomerular filtration rate and renal plasma flow was produced within 10 min of infusion of 12 micrograms TRH over 30 min.	Water	36-41	thyrotropin releasing hormone	Rattus norvegicus	156-159
3571255-14	1987	Like the CD site in oncomodulin, site III in troponin C has not only a lower affinity for calcium relative to the CD site of parvalbumins but also aspartic acid at its -X position; a water molecule bridges the gap between bound metal and the carboxyl group of the relatively short side chain of Asp-114 (Herzberg, O.	Water	183-188	oncomodulin	Homo sapiens	20-31
3571255-16	1987	Hence, we suggest that Asp-59 in oncomodulin binds metal only indirectly through an intervening water molecule, a proposal which is consistent with the CD site"s reduced affinity for ions the size of Ca(II) or smaller.	Water	96-101	oncomodulin	Homo sapiens	33-44
3111194-0	1987	Inhibition of intestinal diamine oxidase by detergents: a problem for drug formulations with water insoluble agents applied by the intravenous route?	Water	93-98	D-amino acid oxidase	Canis lupus familiaris	25-40
3111194-1	1987	One hundred and twenty four water-insoluble drugs were included in a study for their action on diamine oxidase (DAO) after solubilization with 61 detergents.	Water	28-33	D-amino acid oxidase	Canis lupus familiaris	95-110
3111194-1	1987	One hundred and twenty four water-insoluble drugs were included in a study for their action on diamine oxidase (DAO) after solubilization with 61 detergents.	Water	28-33	D-amino acid oxidase	Canis lupus familiaris	112-115
3111194-4	1987	Only 5 detergents fulfilled all prerequisites for our DAO assay, including the solubilization of 76 water-insoluble drugs.	Water	100-105	D-amino acid oxidase	Canis lupus familiaris	54-57
3826356-9	1987	These data reveal the presence, in the lease dense fraction of normal human erythrocytes, of a pathway for K+ transport that is dependent on volume, pH, and chloride, is inhibited by internal Mg2+, and possibly plays a role in determining the erythrocyte water and cation content.	Water	255-260	mucin 7, secreted	Homo sapiens	192-195
3805723-4	1987	We established that lymphocytes from IRBP immunized donor rats were capable of transferring EAU after in vitro stimulation with either IRBP (lymph node or spleen cells) or concanavalin A (spleen cells only).	Water	92-95	retinol binding protein 3	Homo sapiens	37-41
3029085-10	1987	Also, CDP-choline is the preferred water-soluble substrate when compared to CDP-ethanolamine.	Water	35-40	cut-like homeobox 1	Rattus norvegicus	6-9
3029264-2	1987	The G6PD-stimulating activity of both hypothalamic extract and plasma is soluble in water and insoluble in chloroform.	Water	84-89	glucose-6-phosphate dehydrogenase	Rattus norvegicus	4-8
3789193-1	1986	We investigated whether the increased intake of water during dietary electrolyte depletion is related to activation of the renin-angiotensin system.	Water	48-53	renin	Rattus norvegicus	123-128
3801398-8	1986	Interesting features of the structure include possible intra- and interchain sugar-phosphate attractions and a hydration tunnel inside the minor groove capable of accommodating three types of water molecules that aid in helix stabilization via hydrogen bonding.	Water	192-197	activation induced cytidine deaminase	Homo sapiens	213-216
3797454-2	1986	To determine the rate constants of hydrolysis (in 50% water-ethanol medium) the model of successive reactions of first order A----B----C has been used.	Water	54-59	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	125-136
2941420-1	1986	Chemical reduction of human plasma lipoprotein(a) (Lp(a)) yielded two water-soluble products which were separated by rate zonal ultracentrifugation.	Water	70-75	lipoprotein(a)	Homo sapiens	51-56
3725464-3	1986	Mean Pdi was 53 +/- 17 cm H2O and ranged from a minimum of 29 cm H2O to a maximum of 83 cm H2O.	Water	26-29	prolyl 4-hydroxylase subunit beta	Homo sapiens	5-8
3725464-3	1986	Mean Pdi was 53 +/- 17 cm H2O and ranged from a minimum of 29 cm H2O to a maximum of 83 cm H2O.	Water	65-68	prolyl 4-hydroxylase subunit beta	Homo sapiens	5-8
3725464-3	1986	Mean Pdi was 53 +/- 17 cm H2O and ranged from a minimum of 29 cm H2O to a maximum of 83 cm H2O.	Water	65-68	prolyl 4-hydroxylase subunit beta	Homo sapiens	5-8
3090567-1	1986	The effect of long-term TRH administration through drinking water (0.2 mg/ml) on food and water intake and body weight has been studied in three groups of female rats: (1) thyroidectomized, (2) thyroidectomized receiving daily 250 micrograms/kg of L-T4, (3) sham-operated.	Water	60-65	thyrotropin releasing hormone	Rattus norvegicus	24-27
3718921-1	1986	Laser Raman spectroscopy has been employed to study the structure of the hen egg yolk protein phosvitin in H2O and D2O solutions at neutral and acidic pH (pD) and in the solid state.	Water	107-110	casein kinase 2 beta	Homo sapiens	94-103
18964116-7	1986	It has been shown that the specific surface area for water (S(H(2)O), calculated from aquametric isotherms by using the BET equation, corresponds to the hydrophilic anion-exchanger surface area, as compared to the SH(2)O value calculated from gravimetric isotherms.	Water	53-58	delta/notch like EGF repeat containing	Homo sapiens	120-123
3016558-1	1986	The sodium pump, (Na+ + K+)-ATPase, which is involved in the transport of cations and water movement by the colonic mucosa, may be decreased in various diarrhoeal states.	Water	86-91	dynein axonemal heavy chain 8	Homo sapiens	28-34
3092194-5	1986	rGRF induced a slight water and electrolyte secretion, with an efficacy about ten times smaller than secretin, and a potency about thirty times smaller.	Water	22-27	growth hormone releasing hormone	Rattus norvegicus	0-4
3003189-7	1985	In other experiments, hypertension was reversed in RRM-saline hypertensive rats by restricting their salt intake (substitution of distilled water for drinking).	Water	140-145	RNA binding motif protein 39	Rattus norvegicus	51-54
2416356-3	1985	The inactivation rate of the enzyme in the course of the reaction does not depend on the water content in the system and is described by a Kin value commensurable with the Kin in an aqueous solution.	Water	89-94	Kin17 DNA and RNA binding protein	Homo sapiens	139-142
2416356-3	1985	The inactivation rate of the enzyme in the course of the reaction does not depend on the water content in the system and is described by a Kin value commensurable with the Kin in an aqueous solution.	Water	89-94	Kin17 DNA and RNA binding protein	Homo sapiens	172-175
3903101-9	1985	However, citric acid or phenol-water extracts of diseased cementum shavings (highly endotoxin positive) significantly suppressed HGF growth 58% and 61%, respectively.	Water	31-36	hepatocyte growth factor	Homo sapiens	129-132
4018564-9	1985	The plasma PRL in females increased to about 8 ng/ml 1 day after transfer to fresh water, and high levels (2-4 ng/ml) were maintained during 3-7 days after the transfer.	Water	83-88	prolactin	Oncorhynchus mykiss	11-14
4064560-3	1985	The range of Pdi during maximal sniffs (82-204 cm H2O) had better defined lower limits than Pdi during PImax.	Water	50-53	prolyl 4-hydroxylase subunit beta	Homo sapiens	13-16
3924342-3	1985	The BET measurement was then used to determine the optimum time for animal sacrifice for subsequent measurement of CBF and Ew to minimize both intravascular contamination and washout of butanol and water.	Water	198-203	delta/notch like EGF repeat containing	Homo sapiens	4-7
6297972-1	1982	Two water-soluble carbodiimides, differing in molecular dimensions, have been used to characterize the cytochrome c binding site of bovine heart cytochrome c oxidase.	Water	4-9	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	145-165
2539284-1	1989	We have studied the effect of exogenous calcitonin gene-related peptide on net fluxes of water and electrolytes in the rat small and large intestine.	Water	89-94	calcitonin-related polypeptide alpha	Rattus norvegicus	40-71
3993542-2	1985	The dimer of MDI and MDI treated with water (compound X) were evaluated as possible candidates for the "complex MDI matrix".	Water	38-43	MAFD2	Homo sapiens	21-24
2539284-3	1989	Subsequently, using a single-pass perfusion technique, we observed an immediate dose-dependent secretion of water by the rat colon upon intravenous administration of CGRP.	Water	108-113	calcitonin-related polypeptide alpha	Rattus norvegicus	166-170
3993542-2	1985	The dimer of MDI and MDI treated with water (compound X) were evaluated as possible candidates for the "complex MDI matrix".	Water	38-43	MAFD2	Homo sapiens	21-24
3993542-5	1985	Suggested from these experiments is that MDI forms a hydrate with water and that this hydrate might be the explanation for the ambiguous results obtained when sampling MDI by different techniques in the industrial atmosphere.	Water	66-71	MAFD2	Homo sapiens	41-44
6182336-9	1982	Under the conditions existing in these experimental animals, the linear relationship between FE beta 2M and FE H2O is evidence to suggest that factors affecting proximal tubular water reabsorption also affect beta 2M reabsorption.	Water	111-114	B2M	Canis lupus familiaris	96-103
2526914-4	1989	After hemolysis in water, females showed a significant increase in erythrocyte protein concentration (p less than 0.01) and in (Mg++)ATPase activity (p less than 0.005), whereas males showed a significant decrease in (Ca++)ATPase activity (p less than 0.02).	Water	19-24	dynein axonemal heavy chain 8	Homo sapiens	133-139
6182336-9	1982	Under the conditions existing in these experimental animals, the linear relationship between FE beta 2M and FE H2O is evidence to suggest that factors affecting proximal tubular water reabsorption also affect beta 2M reabsorption.	Water	111-114	B2M	Canis lupus familiaris	209-216
6182336-9	1982	Under the conditions existing in these experimental animals, the linear relationship between FE beta 2M and FE H2O is evidence to suggest that factors affecting proximal tubular water reabsorption also affect beta 2M reabsorption.	Water	178-183	B2M	Canis lupus familiaris	96-103
3968071-3	1985	One monoclonal antibody, bLPL-mAb-7, inhibited completely the apolipoprotein C-II (apo-C-II)-dependent enzymic hydrolysis of trioleoylglycerol in a phospholipid-stabilized emulsion, but had no effect on the hydrolysis of the water-soluble substrate p-nitro-phenylacetate.	Water	225-230	apolipoprotein C2	Bos taurus	62-81
2711403-1	1989	The effects on the choroid plexus (CP) of chronic (22 weeks) exposure to 1, 10 or 100 ppm Cd2+ in the drinking water was studied in adult mice.	Water	111-116	CD2 antigen	Mus musculus	90-93
6095635-1	1984	Oat or bean products, rich in water-soluble fiber, have distinct hypocholesterolemic effects in humans.	Water	30-35	ornithine aminotransferase	Homo sapiens	0-3
6954312-4	1982	The mutation frequencies (determined for the HPRT locus) induced by the process water and NUV radiation were as great as those frequencies seen for far UV light alone.	Water	80-85	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	45-49
2541954-0	1989	mu- and K-opiate receptor agonists reduce plasma neurohypophysial hormone concentrations in water-deprived and normally hydrated rats.	Water	92-97	opioid related nociceptin receptor 1	Rattus norvegicus	0-25
6276149-5	1982	These findings have demonstrated that a proportion (5-10%) of ovarian LH/hCG membrane receptors can be rendered water soluble with preservation of their binding properties and that the specific binding site for LH/hCG is present in proteins much smaller than the predominant 6.5S (mol wt, 194,000) form extracted by nonionic detergents.	Water	112-117	chorionic gonadotropin subunit beta 5	Homo sapiens	73-76
6276149-5	1982	These findings have demonstrated that a proportion (5-10%) of ovarian LH/hCG membrane receptors can be rendered water soluble with preservation of their binding properties and that the specific binding site for LH/hCG is present in proteins much smaller than the predominant 6.5S (mol wt, 194,000) form extracted by nonionic detergents.	Water	112-117	chorionic gonadotropin subunit beta 5	Homo sapiens	214-217
6571571-1	1984	Paramagnetic ions have been used to alter the magnetic relaxation rates 1/T1 and 1/T2 of solvent water protons since the first observations of a proton resonance signal almost four decades ago.	Water	97-102	interleukin 1 receptor like 1	Homo sapiens	74-82
2786129-12	1989	The effect of the mixture of IL-1 alpha and PGE2 compared with the two agents administered separately was greater than the predicted additive effect at transmural pressures above 6 cm H2O.	Water	184-187	interleukin 1 alpha	Bos taurus	29-39
6431661-3	1984	The sterile AHF concentrate, dispensed at 1000 u per vial and lyophilized, was completely dissolved within 3 minutes upon addition of 30 ml of pure water.	Water	148-153	coagulation factor VIII	Homo sapiens	12-15
6293671-2	1982	Kept wet at room temperature, this phosphate is hydrolyzed according to the reaction PO4(3-) + H2O leads to HPO4(2-) + OH-; a tricalcium orthophosphate series is then formed, its general formula is Ca9 (HPO4)x (PO4)6-x (OH)x, O less than or equal to x less than or equal to 1.	Water	95-98	carbonic anhydrase 9	Homo sapiens	198-201
2523740-8	1989	In water, the former transition observed at lower temperature for a low molecular weight sample, U-1, is centered at 3 degrees C and characterized by the specific enthalpy, delta hcal = 3.29 J g-1.	Water	3-8	RNA, U1 small nuclear 1	Homo sapiens	97-100
6120788-2	1982	Ovine growth hormone appears to stimulate equally the absorption of water and NaCl in both the proximal jejunum and in the distal ileum.	Water	68-73	gonadotropin releasing hormone receptor	Rattus norvegicus	6-20
2483074-4	1989	Both main-stream and side-stream cigarette smoke condensates and some fractions, containing water-soluble bases, water-insoluble bases, and polycyclic aromatic hydrocarbons, were found to induce AHH activity in lung and liver, the lung being induced to the greatest extent.	Water	113-118	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	195-198
2920782-1	1989	Assays were carried out to determine the trypsin inhibitor activity present in the water-soluble and water-insoluble fractions of human lenses of various ages.	Water	83-88	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	41-58
7337689-6	1981	Esterase-16 is completely insoluble in water.	Water	39-44	esterase 16	Mus musculus	0-11
2920782-1	1989	Assays were carried out to determine the trypsin inhibitor activity present in the water-soluble and water-insoluble fractions of human lenses of various ages.	Water	101-106	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	41-58
2920782-10	1989	A low molecular weight trypsin inhibitor was isolated from the water-soluble and water-insoluble fractions of human lenses.	Water	63-68	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	23-40
2920782-10	1989	A low molecular weight trypsin inhibitor was isolated from the water-soluble and water-insoluble fractions of human lenses.	Water	81-86	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	23-40
2625294-3	1989	Using new cubic-shaped thermoluminescence detectors (TLD) with small volume the dose distribution is examined in water equivalent material (RW-1).	Water	113-118	transmembrane protein 131	Homo sapiens	140-144
7284228-3	1981	Air samples could be aspirated into the collection bag at flow rates of as low as 1 ml min-1 by allowing the water to drain from the cylinder at a controlled rate.	Water	109-114	prostaglandin D2 receptor	Homo sapiens	79-83
11542186-6	1989	Mg2+ catalysis is attributed to the reaction of the zwitterionic form of the substrate (SH+/-, imidazolide moiety protonated) with OH- rather than reaction of the anionic form (S-, imidazolide moiety deprotonated) with water.	Water	219-224	mucin 7, secreted	Homo sapiens	0-3
7275184-2	1981	Water-in-oil emulsions of metabolizable fatty acid esters, with the non-toxic surfactant Pluronic L122 as emulsifying agent, potentiated the humoral response to bovine serum albumin and staphylococcal toxoid in the mouse.	Water	0-5	albumin	Mus musculus	168-181
6169847-2	1981	Cleavage performed in the presence of 0.15% Nonidet P-40 in water yielded polypeptides of approximately 40,000 (P40) and 25,000 (P25) Mr.	Water	60-65	interleukin 9	Homo sapiens	112-115
11542186-8	1989	In contrast, the absence of Mg2+ the reaction of S- with water competes with the reaction of SH+/- with OH-.	Water	57-62	mucin 7, secreted	Homo sapiens	28-31
3262418-6	1988	In RIF-1 tumors, the extracell water volume at 12 h after IL-1 (395 microI/g) was nearly twice that in untreated controls (215 microI/g).	Water	31-36	interleukin 1 complex	Mus musculus	58-62
6115031-1	1981	Water was chosen as the optimal medium for the extraction of tyrosine hydroxylase (TH) from rat brain.	Water	0-5	tyrosine hydroxylase	Rattus norvegicus	61-81
6115031-1	1981	Water was chosen as the optimal medium for the extraction of tyrosine hydroxylase (TH) from rat brain.	Water	0-5	tyrosine hydroxylase	Rattus norvegicus	83-85
2846391-6	1988	The water-soluble intermediates of the CDP-choline pathway, phosphorylcholine and CDP-choline, accumulated to a lesser extent under Ca2+-free conditions; however, glucose enhanced the levels of these intermediates in the presence and absence of Ca2+.	Water	4-9	cut like homeobox 1	Homo sapiens	39-42
6270682-8	1981	Analysis of the intermediate complexes showed that C5b was the subunit most exposed to water in membrane-bound C5b-7, and C5b and C8 beta were the water-exposed subunits in C5b-8.	Water	147-152	complement C8 beta chain	Homo sapiens	130-137
2846391-6	1988	The water-soluble intermediates of the CDP-choline pathway, phosphorylcholine and CDP-choline, accumulated to a lesser extent under Ca2+-free conditions; however, glucose enhanced the levels of these intermediates in the presence and absence of Ca2+.	Water	4-9	cut like homeobox 1	Homo sapiens	82-85
2460484-3	1988	The overnight rise of plasma BP-28 was significantly altered in children who ate a light meal at 0130 h; in them BP-28 levels started to fall after 0300 h, reached nadir levels at 0400 h, began to rise again by 0700 h, and returned to control levels by 0800 h. Such changes did not occur in children given water alone.	Water	306-311	BP28	Homo sapiens	29-34
6112220-1	1981	The stereochemical course of the phosphoric residue transfer from ADP to water catalyzed by the (Mg2+ + Ca2+)-dependent ATPase of sarcoplasmic reticulum has been determined.	Water	73-78	dynein axonemal heavy chain 8	Homo sapiens	120-126
7334940-4	1981	The strains can grow in peptone water with 1.0 to 4.0% NaC1, but not with no NaC1 or 6.0% NaC1.	Water	32-37	nucleus accumbens associated 1	Homo sapiens	55-59
3183973-4	1988	By administering ethanol in the drinking water, or as part of a low-fat (5% of energy) liquid diet, a significant induction of P450IIE1 and of the activities of the microsomal ethanol oxidizing system and p-nitrophenol hydroxylase was demonstrated in the absence of any significant increase in blood acetone with minimal increase in liver total lipids.	Water	41-46	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	127-135
7419720-11	1980	The effect of AVP on hydraulic water permeability (Lp) was examined by adding raffinose to the bathing medium in both the presence and the absence of AVP.	Water	31-36	arginine vasopressin	Mus musculus	14-17
3247255-6	1988	Water and ethanol intakes were increased only at 10.0 and 0.37 micrograms NPY, respectively.	Water	0-5	pro-neuropeptide Y	Mesocricetus auratus	74-77
7419720-14	1980	These results suggest that AVP has a second site of action in the kidney to increase chloride transport by the medullary thick ascending limb in addition to its well-known effect on the water permeability of the collecting tubule.	Water	186-191	arginine vasopressin	Mus musculus	27-30
3062573-0	1988	Renin-dependent water intake in hypovolemia.	Water	16-21	renin	Rattus norvegicus	0-5
7002532-1	1980	In healthy male subjects the hyperthermic water bath (40 degrees C for 30 min) induced an increase of growth hormone (GH) level in plasma with the increment higher than 5 ng ml-1.	Water	42-47	interleukin 17F	Homo sapiens	174-178
3062573-1	1988	The role of the renin-angiotensin system as a mediator of water intake, induced by hypovolemia after polyethylene glycol (PEG) injection, was investigated.	Water	58-63	renin	Rattus norvegicus	16-21
6105878-0	1980	Purification of a water-soluble Mg2+-ATPase from human erythrocyte membranes.	Water	18-23	dynein axonemal heavy chain 8	Homo sapiens	37-43
3062573-7	1988	We conclude that water intake due to isotonic depletion of the extracellular fluid compartment may depend on the activity of the renin-angiotensin system.	Water	17-22	renin	Rattus norvegicus	129-134
6105878-1	1980	A water-soluble Mg2+-ATPase previously reported (White, M.D.	Water	2-7	dynein axonemal heavy chain 8	Homo sapiens	21-27
2976957-0	1988	Atrial natriuretic peptide inhibits water and sodium intake in rabbits.	Water	36-41	natriuretic peptides A	Oryctolagus cuniculus	0-26
7418271-17	1980	It is suggested that release occurs in response to low alcohol concentrations altering the nature of the water-cell membrane interface, thus producing changes in membrane protein configuration and activation of phospholipase A.	Water	105-110	phospholipase A and acyltransferase 1	Rattus norvegicus	211-226
2971569-1	1988	Water proton nuclear relaxation measurements are used to detect and characterize four distinct intermediate states for Gd3+ bound to Ca2+ sites of sarcoplasmic reticulum Ca2+-ATPase in complexes with ATP analogues.	Water	0-5	dynein axonemal heavy chain 8	Homo sapiens	175-181
7377376-1	1980	Activation of the renin-angiotensin system (RAS) or administration of angiotensin II (AII) will induce water intake.	Water	103-108	renin	Rattus norvegicus	18-23
2971569-2	1988	In the absence of nucleotides, Gd3+ binds to two occluded Ca2+ transport sites on Ca2+-ATPase which have a low accessibility to solvent water.	Water	136-141	dynein axonemal heavy chain 8	Homo sapiens	87-93
2843029-1	1988	Oat and bean products, which contain large amounts of water-soluble fiber, are particularly effective hypocholesterolemic agents.	Water	54-59	ornithine aminotransferase	Homo sapiens	0-3
6329428-1	1984	Rats equipped with stimulating and recording electrodes in the hippocampus were trained to lap water on a variable interval schedule.	Water	95-100	leucine aminopeptidase 3	Rattus norvegicus	91-94
6699007-6	1984	From these results, we propose that Hg(II) reacts with the double bond between C-5 and C-6 to form a mercuronium ion which is opened by the nucleophilic attack of water on C-6.	Water	163-168	complement C6	Homo sapiens	172-175
2460343-5	1988	This repetition also implies that parts of the "pro" portion are very similar to parts of mature LPH, and hence that the "pro" portion may be a water-soluble beta-glycosidase with another cellular location than LPH.	Water	144-149	lactase	Homo sapiens	97-100
6970286-0	1980	A quantitative study of the inhibitory effect of Na+ and Mg2+ on the Ca2+ response of water fibers in the frog tongue.	Water	86-91	mucin 7, secreted	Homo sapiens	57-60
6099783-8	1984	Intravenous infusion of the water soluble renin inhibitor, pepstatinyl-arginine-o-methyl ester (500 micrograms/min), also inhibited pressor responses to renin (approx.	Water	28-33	renin	Rattus norvegicus	42-47
2460343-5	1988	This repetition also implies that parts of the "pro" portion are very similar to parts of mature LPH, and hence that the "pro" portion may be a water-soluble beta-glycosidase with another cellular location than LPH.	Water	144-149	lactase	Homo sapiens	211-214
6099783-8	1984	Intravenous infusion of the water soluble renin inhibitor, pepstatinyl-arginine-o-methyl ester (500 micrograms/min), also inhibited pressor responses to renin (approx.	Water	28-33	renin	Rattus norvegicus	153-158
510507-1	1979	The ingestion of 2 different water loads (7.5 and 15 ml/kg) by healthy subjects stimulated the release of plasma motilin, gastrin, pancreatic polypeptide and VIP.	Water	29-34	pancreatic polypeptide	Homo sapiens	131-153
2970848-1	1988	At least four of the intermediate states of Ca2+-ATPase (and presumably ion transport) can be trapped and characterized using water proton relaxation measurements.	Water	126-131	dynein axonemal heavy chain 8	Homo sapiens	49-55
42854-11	1979	ATX II lowers the surface tension of water.	Water	37-42	diencephalon/mesencephalon homeobox 1	Mus musculus	0-3
6527355-1	1984	Activation and deactivation of the chick thymus glucocorticoid receptor protein was studied in ordinary and heavy water by DNA-cellulose binding of the tritiated triamcinolone acetonide-receptor complex.	Water	114-119	nuclear receptor subfamily 3 group C member 1	Gallus gallus	48-71
2970848-2	1988	Gd3+ binds to two occluded Ca2+ transport sites on Ca2+-ATPase which have a low accessibility to solvent water.	Water	105-110	dynein axonemal heavy chain 8	Homo sapiens	56-62
6226653-4	1983	Upon binding to chloroplast reversible ATPase, the metal coordinates 1 water molecule while the Eu3+-ATP complex does not retain any associated solvent.	Water	71-76	dynein axonemal heavy chain 8	Homo sapiens	39-45
2464514-6	1988	Administration of the aldose reductase inhibitor Statil (ICI 128436) throughout the experiment prevented the increased susceptibility to pressure and the increase in nerve galactitol and water content.	Water	187-192	aldo-keto reductase family 1 member B1	Oryctolagus cuniculus	22-38
6414881-1	1983	The hypothesis that thyrotropin-releasing hormone (TRH) affects salt and water transport in gastropod skin by means of altering the secretion of epithelial surface mucus was tested.	Water	73-78	thyrotropin releasing hormone	Homo sapiens	51-54
472708-4	1979	It is thus proved that the insulin-receptor protein obtained by this method is completely soluble in water.	Water	101-106	insulin receptor	Homo sapiens	27-43
3264549-5	1988	Neonatal rats treated with exogenous EGF exhibited: (1) a dose-dependent reduction in skin redundancy measured by decrease in the height of the dorsal skinfold; (2) a diminution in integumental water content determined by wet weight/dry weight ratios and relative tissue specific gravities; and (3) a rapid fall in midscapular skin temperature within 60 minutes of systemic administration of EGF.	Water	194-199	epidermal growth factor like 1	Rattus norvegicus	37-40
446481-1	1979	In this paper evidence is provided that one of the protein components of the water-soluble fraction of the calf lens binds specifically to deoxyribonuclease I (DNAse I).	Water	77-82	deoxyribonuclease 1	Bos taurus	139-158
446481-1	1979	In this paper evidence is provided that one of the protein components of the water-soluble fraction of the calf lens binds specifically to deoxyribonuclease I (DNAse I).	Water	77-82	deoxyribonuclease 1	Bos taurus	160-167
6305935-2	1983	It was found that the NADPH-dependent transformation of benzene to water-soluble metabolites and to phenol catalyzed by cytochrome P-450 LM2 in membrane vesicles was inhibited by catalase, horseradish peroxidase, superoxide dismutase, and hydroxyl radical scavengers such as mannitol, dimethyl sulfoxide, and catechol, indicating the participation of hydrogen peroxide, superoxide anions, and hydroxyl radicals in the process.	Water	67-72	cytochrome P-450	Oryctolagus cuniculus	120-136
3194576-0	1988	[Is the renin-angiotensin system implicated in the hypertensive effect of a water-soluble tissue extract?].	Water	76-81	renin	Rattus norvegicus	8-13
6555123-6	1983	Water retention in tocolysis with beta 2 stimulants is one of the most important causes for the information of a pulmonary oedema.	Water	0-5	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	34-40
153910-1	1979	The capacity of various ATPase preparations from beef heart mitochondria to catalyze exchange of phosphate oxygens with water has been evaluated.	Water	120-125	dynein axonemal heavy chain 8	Homo sapiens	24-30
153910-5	1979	The purified, soluble ATPase from mitochondria catalyzed little or no intermediate Pi equilibrium HOH exchange at 5 mM ATP but showed pronounced increase in capacity for such exchange as ATP concentration was lowered.	Water	98-101	dynein axonemal heavy chain 8	Homo sapiens	22-28
3163350-4	1988	The prevalence of dental fluorosis in the earliest formed teeth was higher in the area where powdered milk was suspended in fluoride-containing tap water than where pasteurized cow"s milk was used.	Water	148-153	tracheal antimicrobial peptide	Bos taurus	144-147
720830-3	1978	The high concentration of water soluble S-100 protein in whole brain is a recessive character.	Water	26-31	S100 calcium binding protein A1	Mus musculus	40-45
720830-4	1978	The inheritance of total S-100 protein in whole brain and of the level of its water soluble fraction in brain cortex and hippocampus is complex.	Water	78-83	S100 calcium binding protein A1	Mus musculus	25-30
6620356-9	1983	Finally extraction of Triton-insoluble pellet with 0.05 mM ATP-0.10 mM MgCl2 X 6 H2O solubilized 57% of the renal dipeptidase.	Water	81-84	dipeptidase 1	Homo sapiens	108-125
2838982-2	1988	ESR studies on spin-labeled amorphous RNase A as a function of varying concentrations of sorbed H2O and D2O will be presented.	Water	96-99	ribonuclease A family member 1, pancreatic	Homo sapiens	38-45
7174585-7	1982	The method is sensitive to 1 pCi/sample of food ash and to 1 pCi/L of water.	Water	70-75	serpin family A member 5	Homo sapiens	61-64
661225-11	1978	The primary water-soluble metabolite released with arylsulfatase and beta-glucuronidase was 3-hydroxybenzo[alpha]pyrene.	Water	12-17	glucuronidase beta	Homo sapiens	69-87
3148252-6	1988	The acylation-rate constants, kappa 2, are: kappa H2O = 0.32 +/- 0.02 s-1 and kappa NaCl = 3.5 +/- 0.5 s-1, and they correlate to beta-trypsin (the most rapid single-chained form of the enzyme).	Water	50-53	serine protease 1	Homo sapiens	130-142
707000-0	1978	Increased intestinal absorption of insulin in a micellar solution: water-in-oil-in-water insulin micelles.	Water	67-72	insulin	Oryctolagus cuniculus	35-42
707000-0	1978	Increased intestinal absorption of insulin in a micellar solution: water-in-oil-in-water insulin micelles.	Water	67-72	insulin	Oryctolagus cuniculus	89-96
707000-0	1978	Increased intestinal absorption of insulin in a micellar solution: water-in-oil-in-water insulin micelles.	Water	83-88	insulin	Oryctolagus cuniculus	35-42
707000-1	1978	Water-in-oil-in-water (W/O/W) insulin micelles were prepared, and the possibility of insulin absorption in a micellar form was examined.	Water	0-5	insulin	Oryctolagus cuniculus	30-37
6818682-6	1982	The intragastric basal pressure was immediately reduced in all after TRH injection (-2.5 +/- 0.48 cm H2O pressure).	Water	101-104	thyrotropin releasing hormone	Homo sapiens	69-72
7143478-5	1982	Hepatic mitochondrial aldehyde dehydrogenase (ALDH) was decreased, compared to controls, by hypobarometric pressure in water-drinking animals.	Water	119-124	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	46-50
3391159-1	1988	Adenosine deaminase from bovine skeletal muscle catalyzes the hydrolytic deamination of adenosine to inosine and ammonia via an ordered Uni-Bi mechanism, if water is not considered as a true second substrate, as deduced from the inhibition pattern products.	Water	157-162	adenosine deaminase	Bos taurus	0-19
6813881-5	1982	It was concluded that the medial hypothalamus is the most sensitive site of TRH-induced anorexia and adipsia and the action of TRH on the lateral hypothalamus is also a possible mechanism mediating the decrease in water intake.	Water	214-219	thyrotropin releasing hormone	Rattus norvegicus	127-130
3653518-14	1987	Third, following incubation of the eggs in water for activation, the time course of the appearance of 9-kDa PSGP and the breakdown of 200-kDa PSGP was observed.	Water	43-48	polysialoglycoprotein	Oncorhynchus mykiss	108-112
16662415-4	1982	(d) The generation of water-oxidation activity was not affected by the inhibitors of ATP formation and CO(2) fixation, but was inhibited by nitrite, methylviologen and phenylmercuric acetate which suppress or inhibit the reduction of ferredoxin in intact chloroplasts.	Water	22-27	ferredoxin-6, chloroplastic	Triticum aestivum	234-244
590427-1	1977	The authors have developed a method for long-term permanent application of water soluble substances by a intraperitoneal depot capsule [KLINGENBERG et al., Exp.	Water	75-80	muscleblind like splicing regulator 1	Homo sapiens	156-159
404133-5	1977	At a dose of 3 nmoles, LHRH, SRIF, and TRH suppressed water intake alh.	Water	54-59	thyrotropin releasing hormone	Rattus norvegicus	39-42
3653518-14	1987	Third, following incubation of the eggs in water for activation, the time course of the appearance of 9-kDa PSGP and the breakdown of 200-kDa PSGP was observed.	Water	43-48	polysialoglycoprotein	Oncorhynchus mykiss	142-146
7044934-1	1982	A possibility of interaction between effects of insulin and vasopressin (ADH) on renal handling of water and electrolytes was examined in continuously hydrated rats whose hypothalamo-hypophysial antidiuretic system was blocked with ethanol.	Water	99-104	alcohol dehydrogenase 1C (class I), gamma polypeptide	Rattus norvegicus	73-76
3504965-3	1987	The simulation of the crystalline state (MDC) concerns a system of 4 unit cells containing 16 cyclosporin A molecules and 22 water molecules, which is simulated using crystalline periodic boundary conditions.	Water	125-130	C-C motif chemokine ligand 22	Homo sapiens	41-44
7032773-0	1981	Induction of leucocyte migration inhibitory factor (LIF) by stimulation with free hapten and water-insoluble epoxy resin.	Water	93-98	leukemia inhibitory factor	Cavia porcellus	52-55
7236849-1	1981	The assigned exchangeable proton signals in the proton nuclear magnetic resonance spectra of sperm whale deoxy and Met-cyano myoglobin in H2O solution were found to exhibit pH-dependent saturation transfer from the bulk water, which allowed determination of the kinetics and mechanism of the labile proton exchange with solvent.	Water	138-141	myoglobin	Physeter catodon	125-134
7236849-1	1981	The assigned exchangeable proton signals in the proton nuclear magnetic resonance spectra of sperm whale deoxy and Met-cyano myoglobin in H2O solution were found to exhibit pH-dependent saturation transfer from the bulk water, which allowed determination of the kinetics and mechanism of the labile proton exchange with solvent.	Water	220-225	myoglobin	Physeter catodon	125-134
7262045-5	1981	Both, the reduced GFR as well as the impaired free water clearance are functionally linked to the diminished transport capacity of the diluting segment by the tubuloglomerular feedback mechanism and the ADH mechanism respectively.	Water	51-56	alcohol dehydrogenase 1C (class I), gamma polypeptide	Rattus norvegicus	203-206
7225466-8	1981	The interaction between lipase and colipase is enhanced when the complex is adsorbed at the lipid-water interface.	Water	98-103	colipase	Equus caballus	35-43
7260125-3	1981	In "pathological" thyroglobulin in the regions inaccessible for water there are located only 68% of trypthophanyls.	Water	64-69	thyroglobulin	Homo sapiens	18-31
7446616-1	1980	Measurements with the use of tritiated water (3H2O) in human volunteers indicate that the mean tritiated water half life (t1/2 3H2O) in the uterine cavity is 1.3 minutes.	Water	39-44	interleukin 1 receptor like 1	Homo sapiens	122-131
7446616-1	1980	Measurements with the use of tritiated water (3H2O) in human volunteers indicate that the mean tritiated water half life (t1/2 3H2O) in the uterine cavity is 1.3 minutes.	Water	105-110	interleukin 1 receptor like 1	Homo sapiens	122-131
7446616-4	1980	According to the formula aVc divided by 2 x 1,440 divided by (t1/2 3H2O) water turnover in the human endometrial canal is calculated to range from 222 to 332 ml/24 hours.	Water	73-78	interleukin 1 receptor like 1	Homo sapiens	62-71
6995929-5	1980	These data indicate a critical role of renin in the rise of blood pressure and water intake after initial application of a renal artery clip as well as after reapplication of the clip to declipped rats.	Water	79-84	renin	Rattus norvegicus	39-44
6104674-3	1980	A mixture of MIF and its metabolites derivatized with Dns chloride was adequately resolved by two-dimensional chromatography on polyamide layer with solvent systems, formic acid-water (3:97) and benzene-acetic acid (9:1).	Water	178-183	macrophage migration inhibitory factor	Homo sapiens	13-16
6769091-8	1980	Acid maltase is almost completely extracted with water, whereas renal maltase is extracted only with Triton.	Water	49-54	alpha glucosidase	Homo sapiens	0-12
7381776-8	1980	It is proposed that the quantitative relationship between ADH and urine flow is dependent upon the previous history of water consumption.	Water	119-124	alcohol dehydrogenase 4 (class II), pi polypeptide	Rattus norvegicus	58-61
6991212-0	1980	Secretion of arginin-vasopressin, aldosterone and corticosterone and plasma-renin activity in water-deprived rats.	Water	94-99	renin	Rattus norvegicus	76-81
396073-8	1979	The injection of a mixture of renin and kallikrein attenuated the effect of renin alone, indicating that both enzymes exert antagonistic actions on the excretion of electrolytes and water by the kidneys.	Water	182-187	renin	Rattus norvegicus	30-35
396073-10	1979	A purified fraction of kidney extract containing no kallikrein and only traces of renin activity, had a stimulatory effect on kallikrein, water and electrolyte excretion.	Water	138-143	renin	Rattus norvegicus	82-87
518552-12	1979	Band ultracentrifugation in (2)H(2)O-containing iso-osmotic buffers showed that mucin 1 contained a major fast-sedimenting component (s(o)=37+/-2S), and a minor amount of a slower-sedimenting component.	Water	31-36	mucin 1, cell surface associated	Homo sapiens	80-87
447727-5	1979	It is concluded that trioleoylglycerol was present in lenses on the surface of the aqueous subphase, that hydrolysis by lipoprotein lipase occurred in or near the lipid/argon-water interface, and that lipolytic products immediately located and spread throughout the interface, displacing substances with lower spreading pressures from the interface.	Water	175-180	lipoprotein lipase	Bos taurus	120-138
153149-3	1978	A quantitative treatment of ATP in equilibrium HOH exchange is given to allow extraction of elementary rate constants from the data.	Water	47-50	ATPase phospholipid transporting 8A2	Homo sapiens	28-31
216760-1	1978	Inhibition of adenosinetriphosphatase (ATPase) by vanadium pentoxide (dissolved in water or in sodium hydroxide solution) was studied in microsomal fractions and tissue homogenates of kidney, brain, and heart of several species, including humans (kidney only).	Water	83-88	ATPase Na+/K+ transporting subunit beta 1	Homo sapiens	14-37
656460-3	1978	T/eta (a and b are temperature-independent constants, T is the temperature (K), eta is the viscosity of water, (cP).	Water	104-109	endothelin receptor type A	Homo sapiens	2-5
656460-3	1978	T/eta (a and b are temperature-independent constants, T is the temperature (K), eta is the viscosity of water, (cP).	Water	104-109	endothelin receptor type A	Homo sapiens	80-83
148870-0	1978	Increased conformational stability of mitochondrial soluble ATPase (F1) by substitution of H2O for D2O.	Water	91-94	dynein axonemal heavy chain 8	Homo sapiens	60-66
580813-4	1978	The inhibitory effect of albumin was potentiated by humidity; saturation of the atmosphere with water vapor at 37 degrees C abolished the DPL character of DPL-RSA mixtures and prevented its return (zero surface tension) upon reversal of the atmosphere from saturated water vapor to dry air.	Water	96-101	prion like protein doppel	Homo sapiens	138-141
580813-4	1978	The inhibitory effect of albumin was potentiated by humidity; saturation of the atmosphere with water vapor at 37 degrees C abolished the DPL character of DPL-RSA mixtures and prevented its return (zero surface tension) upon reversal of the atmosphere from saturated water vapor to dry air.	Water	96-101	prion like protein doppel	Homo sapiens	155-158
626921-2	1978	Highly significant differences in the concentrations of the water-soluble S-100 protein were found between some strains.	Water	60-65	S100 calcium binding protein A1	Mus musculus	74-79
560299-2	1977	Longitudinal and transverse proton relaxation rates for water in the hydration spheres of Gd(III) bound to the non-immune rabbit IgG fragments Fc (C-terminal half of heavy-chain dimer), pFc" (C-terminal quarter of heavy-chain dimer) and Fab (N-terminal half of heavy and light chain) have been measured at a number of frequencies and temperatures using pulsed nuclear magnetic resonance spectrometry.	Water	56-61	immunoglobulin heavy chain (V7183 family)	Mus musculus	129-132
844914-3	1977	Aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity and metabolism of benzo(a)pyrene to water-soluble products were measured in cultures of body fibroblasts and kidney epithelial cells from different human embryos.	Water	97-102	aryl hydrocarbon receptor repressor	Homo sapiens	47-50
265081-6	1977	Enamel fluorosis can be avoided or minimized in areas with up to at least 1.2 mgF/l water if F-supply, e.g. water-diluted gruel and/or supplementary fluoride, is not commenced until 6 months of age when body weight is higher.	Water	84-89	interferon beta 1	Homo sapiens	90-94
1021223-1	1976	The injection or infusion of NIAMDD prolactin (NIH P-S-10) into unanesthetized rats resulted in water and electrolyte retention with a large increase in urine osmolality but no effect on glomerular filtration rate.	Water	96-101	eukaryotic translation elongation factor 1 alpha 2	Rattus norvegicus	51-57
959674-4	1976	In 5 subjects a transient increase in Pdi of 25-150 cm H2O consistently produced a transient increase in expired N2 concentration of 1.80 +/- 0.06% (Mean +/- 1 SE); in 1 subject N2 concentration decreased by 0.8% to 2.7% N2, and in one subject the alveolar plateau was uninfluenced by changes in Pdi.	Water	55-58	prolyl 4-hydroxylase subunit beta	Homo sapiens	38-41
1276900-4	1976	(4) In a second series of 12 animals lesions of the subfornical organ attenuated water intake in response to a peripheral injection of renin or isoproteronol without disrupting drinking to peripheral administration of hypertonic saline or polyethylene glycol or to 24 h water deprivation.	Water	81-86	renin	Rattus norvegicus	135-140
400-2	1976	Digestion of intact membrane vesicles with soluble trypsin inactivates the water-splitting system, the 3-(3,4-dichlorophenyl)-1,1-dimethylurea inhibition site of Photosystem II, the electron transport between the two photosystems as well as the ferredoxin NADP reductase.	Water	75-80	ferredoxin reductase	Homo sapiens	245-270
60142-3	1976	Rat alpha-foetoprotein (AFP) was shown to inhibit the formation of water soluble metabolities of oestrone and oestradiol by incubation with microsomes from rat liver in the presence of NADPH.	Water	67-72	alpha-fetoprotein	Rattus norvegicus	4-22
60142-3	1976	Rat alpha-foetoprotein (AFP) was shown to inhibit the formation of water soluble metabolities of oestrone and oestradiol by incubation with microsomes from rat liver in the presence of NADPH.	Water	67-72	alpha-fetoprotein	Rattus norvegicus	24-27
189473-6	1976	The cytochrome c conformation in water solution and in the complex does not differ significantly.	Water	33-38	LOC104968582	Bos taurus	4-16
810901-1	1975	Plasma renin activity was found to be correlated positively with muscle water content and the presence of oedema in rats with protein energy malnutrition, whereas the muscle potassium content showed a negative correlation with muscle water content.	Water	72-77	renin	Rattus norvegicus	7-12
810901-4	1975	It is therefore concluded that, although the inability to balance consumption and excretion of water may in part be the result of increased effective plasma renin activity, the increased plasma concentration results from increased secretion rather than from decreased inactivation.	Water	95-100	renin	Rattus norvegicus	157-162
1158888-10	1975	Mild acid hydrolysis of the 1/10.3 soluble material released water-soluble, neutral 14C-oligosaccharides which eluted from Sephadex G-50 in two or three peaks between the standards cytochrome c and GDP-mannose...	Water	61-66	LOC104968582	Bos taurus	181-193
169890-3	1975	The nuclear magnetic relaxation (NMR) rate of formate and water protons is enhanced by the presence of ferric horse liver catalase.	Water	58-63	catalase	Equus caballus	122-130
169890-6	1975	Evidence that water forms an innersphere complex with the iron atom of the catalase heme is presented.	Water	14-19	catalase	Equus caballus	75-83
809721-6	1975	A relationship was found in rats between the amount of TRH ingested in drinking water and plasma levels of PRL and TSH; hormonal stores in the adenohypophysis usually declined.	Water	80-85	thyrotropin releasing hormone	Rattus norvegicus	55-58
4549968-0	1974	Analytical application of the stereospecific hydrogen exchange reaction between (R)-carnitine and water, catalyzed by (R)-carnitine dehydrogenase and alpha-lipoamide dehydrogenase (diaphorase).	Water	98-103	dihydrolipoamide dehydrogenase	Homo sapiens	181-191
4523049-0	1973	Fluoride contents of water supply in different regions in Irag.	Water	21-26	inositol 1,4,5-triphosphate receptor associated 1	Homo sapiens	58-62
4339394-2	1972	Synthetic angiotensin II (Hypertensin, Ciba, Basel) was incubated with a water-insoluble preparation of plasmin (E.C.	Water	73-78	plasminogen	Homo sapiens	104-111
5419436-0	1970	Mathematical models as an aid in the solution of water pollution control problems.	Water	49-54	activation induced cytidine deaminase	Homo sapiens	26-29
5881657-2	1965	When solutions of ;soluble" or transfer RNA (s-RNA) and of cytochrome c in phenol-acetic acid-water were mixed, intractable coacervates were formed.	Water	94-99	cytochrome c	Oryctolagus cuniculus	59-71
146396-2	1978	In the control animals receiving the solvent mixture (glycerol:ethanol:water in 1:1:1) a transient decrease in the lactate dehydrogenase and citrate synthase activity levels was observed.	Water	71-76	citrate synthase	Rattus norvegicus	141-157
710363-24	1978	Vestibular stimulation with cold or warm water in the ear gives an increase of rCBF in the parietal regions.	Water	41-46	CCAAT/enhancer binding protein zeta	Rattus norvegicus	79-83
2443589-7	1987	The water-soluble singlet oxygen scavengers L-histidine (50 mmol/L) and sodium azide (100 mmol/L) completely prevented the photodynamic effects of uroporphyrin (100 mumol/L) on HBP.	Water	4-9	heme binding protein 1	Homo sapiens	177-180
625013-3	1978	Pharmacological activation of the renin-angiotensin system with isoprenaline or phentolamine caused increased intake of water but did not stimulate sodium appetite in sodium-replete adrenalectomized rats, and decreased sodium appetite in sodium-depleted adrenalectomized animals.3.	Water	120-125	renin	Rattus norvegicus	34-39
625013-11	1978	In conclusion, peripheral activation of the renin-angiotensin system stimulates water intake but has no direct effect on sodium appetite.	Water	80-85	renin	Rattus norvegicus	44-49
590636-7	1977	These results, which give no evidence of a direct effect of insulin on electrolyte transport in brain, are in sharp contrast with those found in anesthetized rabbits, which suggested that insulin affects brain potassium and water content before any change in plasma glucose occurs.	Water	224-229	insulin	Oryctolagus cuniculus	188-195
14261580-0	1965	WATER COOLING: FIRST-AID TREATMENT FOR SCALDS AND BURNS.	Water	0-5	activation induced cytidine deaminase	Homo sapiens	21-24
3673112-10	1987	14C-TR-2 incubated anaerobically in sheep ileum contents was 95% transformed into more polar metabolites, the majority of the radiolabelled metabolites isolated being water soluble.	Water	167-172	nuclear receptor subfamily 2, group C, member 1	Rattus norvegicus	4-8
14193929-0	1964	SOME EFFECTS OF GROWTH HORMONE ON WATER DIURESIS IN RATS.	Water	34-39	gonadotropin releasing hormone receptor	Rattus norvegicus	16-30
411504-1	1977	Proton relaxation studies of the interactions with hog kidney diamine oxidase of water, substrate-analogue inhibitors, and product analogues indicate that the active site Cu(II) is not located near the oxidizing site of the enzyme, rather near the nonoxidized end of the binding substrate.	Water	81-86	amine oxidase copper containing 1	Homo sapiens	62-77
3581863-3	1987	On the other hand, S-Ag was found to induce EAU in the majority of immunized guinea pigs, with changes more severe than those induced by IRBP.	Water	44-47	S-arrestin	Cavia porcellus	19-23
321006-1	1977	Measurements of the relaxation rate of water protons (PRR) have been used to study the interaction of yeast phosphoglycerate kinase with the manganous complexes of a number of nucleotides.	Water	39-44	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	108-131
320258-2	1977	Sera from animals treated with niridazole blocked the in vitro production of migration inhibitory factor (MIF) while niridazole itself was inactive, suggesting that these effects are caused by water soluble mediators.	Water	193-198	macrophage migration inhibitory factor	Homo sapiens	77-104
13969508-0	1962	[Action of different inhibitors of L-DOPA decarboxylase on the water ration, diuresis and urinary sodium and potassium elimination in rats].	Water	63-68	dopa decarboxylase	Rattus norvegicus	35-55
13797759-0	1960	[A "drinking aid" for the seriously ill and its significance for maintenance of water-electrolyte balance].	Water	80-85	activation induced cytidine deaminase	Homo sapiens	13-17
320258-2	1977	Sera from animals treated with niridazole blocked the in vitro production of migration inhibitory factor (MIF) while niridazole itself was inactive, suggesting that these effects are caused by water soluble mediators.	Water	193-198	macrophage migration inhibitory factor	Homo sapiens	106-109
3103674-3	1986	Using membrane-inlet mass spectrometry, we have measured 18O exchange between CO2 and H2O catalyzed by native zinc-containing and cobalt(II)-substituted carbonic anhydrase III from bovine skeletal muscle near pH 7.5.	Water	86-89	carbonic anhydrase 3	Bos taurus	153-175
920254-2	1977	With the aid of tritiated water it was possible to estimate the fluid turnover in the cysts and compare it with their volume, pressure and potassium and creatinine levels.	Water	26-31	activation induced cytidine deaminase	Homo sapiens	9-12
32196151-3	1960	The corrosion current-density for mint silver in sheet form is 1.1 x 10-8 amp cm-2 for 20 percent aqueous solutions of perchloric acid, 1.3x10-9 amp cm-2 for 20 percent aqueous solutions of perchloric acid containing 0.5 percent silver perchlorate, and within the limits of detection is zero for conductivity water.	Water	309-314	spen family transcriptional repressor	Homo sapiens	34-38
3799198-4	1986	Determinations of chloroform:water partition coefficients showed that lipophilic complexes are formed at equilibrations between Ni2+ or Cd2+ and zinc pyridinethione.	Water	29-34	CD2 antigen	Mus musculus	136-139
194267-6	1977	Water deprivation increased plasma (Na+), hematocrit, vasopressin content and renin activity but saralasin treatment did not reduce water intake after 30 or 60 min.	Water	0-5	renin	Rattus norvegicus	78-83
3524679-1	1986	Ferredoxin which had been modified with glycine ethylester in the presence of a water-soluble carbodiimide to the extent of one carboxyl-group modified per ferredoxin was subjected to peptide mapping in an attempt to locate the site(s) of modification.	Water	80-85	ferredoxin reductase	Homo sapiens	0-10
986542-9	1976	The results indicate that in such an environment, adenosine aminohydrolase would be expected to be less efficient a catalyst, but equally susceptible to product inhibition, as compared to media of dielectric constant approaching that of water.	Water	237-242	adenosine deaminase	Bos taurus	50-74
2873058-2	1986	At 70 degrees C and an initial water concentration of 13 microliters per ml organic solvent (toluene), the half-life of the ATPase was approx.	Water	31-36	dynein axonemal heavy chain 8	Homo sapiens	124-130
8823-3	1976	Upon saturation of the atmosphere with water vapor in equilibrium with the aqueous phase at 37 degrees C in a closed chamber, DPL lost the ability to produce zero surface tension, and the gamma min of the DPL film increased from zero to 22 dyne/cm.	Water	39-44	prion like protein doppel	Homo sapiens	126-129
8823-3	1976	Upon saturation of the atmosphere with water vapor in equilibrium with the aqueous phase at 37 degrees C in a closed chamber, DPL lost the ability to produce zero surface tension, and the gamma min of the DPL film increased from zero to 22 dyne/cm.	Water	39-44	prion like protein doppel	Homo sapiens	205-208
8823-5	1976	However, when the chloroform solution of DPL was added to 0.15 M NaCl before sonication, the adsorbed film produced immediately a stable gamma min of zero in a saturated atmosphere, 37 degrees C. In the absence of chloroform, with DPL adsorbed from either distilled water or 0.15 M NaCl, the effect of humidity was reversed either by removing the chamber and returning the wet film to room air or by introducing small quantities of dispersing agents such as cholesteryl palmitate.	Water	266-271	prion like protein doppel	Homo sapiens	41-44
2873058-4	1986	At this latter concentration of water the half-life of the ATPase at 90, 80 and 70 degrees C was 5, 48 and 96 h, respectively.	Water	32-37	dynein axonemal heavy chain 8	Homo sapiens	59-65
133717-0	1976	A water-soluble Mg2+-ATPase from erythrocyte membranes.	Water	2-7	dynein axonemal heavy chain 8	Homo sapiens	21-27
133717-1	1976	A ouabain-insensitive ATPase activity associated with the water-soluble proteins of the human and bovine erythrocyte membrane is demonstrated by means of activity-staining in polyacrylamide gels.	Water	58-63	dynein axonemal heavy chain 8	Homo sapiens	22-28
3697358-3	1986	Since OSCN- can form the weak acid HOSCN (pKa = 5.3), the equilibrium constant expression (Kox) for thiocyanate peroxidation is dependent on the concentration of hydrogen ions as well as the concentrations of H2O2, SCN-, HOSCN, OSCN- and water, and on the HOSCN ionization constant, Ka: (Formula: see text).	Water	238-243	NADPH oxidase 4	Homo sapiens	91-94
2282-8	1976	Gn-RH, therefore, appears to behave as a random coil polypeptide in water devoid of any intrachain residue interactions.	Water	68-73	gonadotropin releasing hormone 1	Homo sapiens	0-5
2282-10	1976	In contrast to its behavior in water, Gn-RH in trifluoroethanol exhibits a conformational transition, with the formation of a beta structure.	Water	31-36	gonadotropin releasing hormone 1	Homo sapiens	38-43
3697358-4	1986	The concentration of water is assumed to be constant and unaffected by the other components and is omitted from the Kox equation.	Water	21-26	NADPH oxidase 4	Homo sapiens	116-119
3005043-3	1986	The presence of tris(picolinato)manganese(II) [MnII(PA)2(PAH)(H2O)], a model complex for mitochondrial superoxide dismutase, (i) efficiently catalyzes the disproportionation of O2.-, (ii) precludes the formation HO2., and thereby (iii) prevents hydrogen abstraction from allylic and thiol groups.	Water	62-65	heme oxygenase 2	Homo sapiens	212-215
2125-1	1975	Water soluble pig insulin (4 x 10(-8) to 4 x 10(-7) g/ml) produced a marked and long-lasting increase in the contractile force of the rabbit auricle in vitro.	Water	0-5	insulin	Oryctolagus cuniculus	18-25
3786512-6	1986	It appears that reduced secretion of GH and TSH observed in water restricted rats would be due to the concomitant reduction in food intake.	Water	60-65	gonadotropin releasing hormone receptor	Rattus norvegicus	37-39
825378-8	1975	Furthermore, these results suggest a complex interrelationship between PG-synthetase action, activation of the renal renin-angiotensin system and urinary water and sodium excretion.	Water	154-159	renin	Rattus norvegicus	117-122
131792-3	1975	The rate of H-meromyosin ATPase in the steady state decreased in D2O to 60% of that in H2O.	Water	87-90	dynein axonemal heavy chain 8	Homo sapiens	25-31
3913393-4	1985	In such renin-depleted rats with subnormal plasma renin levels, morphine and isoprenaline-induced water intakes were linearly related to pre-injection basal plasma renin level.	Water	98-103	renin	Rattus norvegicus	8-13
1190111-5	1975	The increase in fat was accompanied by an increase in water content.	Water	54-59	FAT atypical cadherin 1	Homo sapiens	16-19
3913755-8	1985	Afferent and efferent renal nerve activity appear to be closely related since recent experiments by our group have provided further evidence of the existence of neural renorenal reflexes by which one kidney exerts a tonic inhibitory effect on the release of renin from juxtaglomerular cells and on tubular sodium and water reabsorption of the contralateral kidney.	Water	317-322	renin	Rattus norvegicus	258-263
124244-0	1975	[Proton transfer from water to octane, catalyzed by soluble bacterial ATPase].	Water	22-27	dynein axonemal heavy chain 8	Homo sapiens	70-77
4080819-1	1985	A water-equivalent plastic material RW-1, in the form of thin foils as well as of thicker sheets, has been produced by melting powdered polyethylene together with CaCO3 and MgO.	Water	2-7	transmembrane protein 131	Homo sapiens	36-40
4052438-1	1985	The mechanism of cholesterol esterase- (carboxylic ester hydrolase, EC 8.1.1.1) catalyzed hydrolysis of the water-soluble ester p-nitrophenyl butyrate has been characterized for commercially available preparations from bovine and porcine pancreas and for a purified preparation from porcine pancreas.	Water	108-113	carboxyl ester lipase	Bos taurus	17-37
163209-0	1975	Charge transfer between water and octane phases by soluble mitochondrial ATPase (F1), bacteriorhodopsin and respiratory chain enzymes.	Water	24-29	ATP synthase F1 subunit epsilon	Homo sapiens	59-79
4369372-6	1974	Donated H bonds from OH-3, OH-4 and OH-6 and an accepted H bond to OH-2 of the d-hexose are important for the binding of the sugar substrate to galactokinase.	Water	67-71	galactokinase	Saccharomyces cerevisiae S288C	144-157
3160805-7	1985	Treatment of surface-bound 125I-IL-1 with bivalent water-soluble crosslinkers identified a membrane polypeptide of Mr 79,500 to which IL-1 is crosslinked.	Water	51-56	interleukin 1 complex	Mus musculus	32-36
4738150-0	1973	The specific interaction of myelin basic protein with lipids at the air-water interface.	Water	72-77	myelin basic protein	Homo sapiens	28-48
3160805-7	1985	Treatment of surface-bound 125I-IL-1 with bivalent water-soluble crosslinkers identified a membrane polypeptide of Mr 79,500 to which IL-1 is crosslinked.	Water	51-56	interleukin 1 complex	Mus musculus	134-138
4056689-3	1985	Within 1 day after transfer to full seawater we observed a plasma PRL decrease, which stayed significantly lower (3-5 ng/ml) than the fresh water control group (10-15 ng/ml) during the entire experiment.	Water	39-44	prolactin	Oncorhynchus mykiss	66-69
4685082-7	1973	When plasma glucose was rapidly lowered to normal with insulin, there was gross brain edema, increases in brain content of water, Na+, K+, Cl- and idiogenic osmoles, and a significant osmotic gradient from brain (326 mosmol/kg H(2)O) to plasma (287 mosmol/kg).	Water	123-128	insulin	Oryctolagus cuniculus	55-62
4056689-4	1985	Pituitary PRL content showed an initial abrupt increase, but after 3 weeks in seawater pituitary PRL content had decreased to the same level as in the fresh water control group.	Water	81-86	prolactin	Oncorhynchus mykiss	97-100
4056689-5	1985	On the contrary, transfer from seawater to fresh water was followed within 1 day by a rise in plasma PRL levels, which stayed high (10-15 ng/ml) after 3 weeks in fresh water.	Water	34-39	prolactin	Oncorhynchus mykiss	101-104
4056689-5	1985	On the contrary, transfer from seawater to fresh water was followed within 1 day by a rise in plasma PRL levels, which stayed high (10-15 ng/ml) after 3 weeks in fresh water.	Water	49-54	prolactin	Oncorhynchus mykiss	101-104
4340120-0	1972	Water-insoluble enzymes for peptide sequencing: dipeptidyl aminopeptidase I (cathepsin C), an enzyme with subunit structure.	Water	0-5	cathepsin C	Homo sapiens	77-88
3897519-1	1985	Captopril caused a renin-dependent increase in water intake in rats with bilateral ureteric ligation.	Water	47-52	renin	Rattus norvegicus	19-24
4998809-0	1971	A new assay for histaminase activity: measurement of tritiated water from beta (side chain label)-H 3-histamine.	Water	63-68	amine oxidase copper containing 1	Homo sapiens	16-27
2931284-6	1985	5,7-DHT and PCPA pretreatment decreased forebrain 5-HT content and prevented ADH increases involved by water deprivation, suggesting that 5HT is necessary for the hormonal response to osmotic stimuli.	Water	103-108	alcohol dehydrogenase 1C (class I), gamma polypeptide	Rattus norvegicus	77-80
24174191-12	1970	The first water-soluble fraction contains a Mg(++)-activated ATPase.	Water	10-15	dynein axonemal heavy chain 8	Homo sapiens	61-67
4006555-5	1985	The PIP was less than 75 cm H2O in only one patient and delta PDI was greater than 45 cm H2O in all ten patients evaluated.	Water	89-92	prolyl 4-hydroxylase subunit beta	Homo sapiens	62-65
4251799-0	1970	[The effect of thiophosphamide on the ATP-ase activity of the strucuural and water-soluble proteins of Guerin carcinoma and its drug resistant variant].	Water	77-82	dynein axonemal heavy chain 8	Homo sapiens	38-45
5455644-0	1970	Comparison of renal tubular transport of urate and PAH in water snakes: evidence for differences in mechanisms and sites of transport.	Water	58-63	phenylalanine hydroxylase	Homo sapiens	51-54
14411379-0	1959	The effects of an intracarotid injection of hyperosmotic NaC1 solutions on water, sodium and potassium excretion in the human being.	Water	75-80	nucleus accumbens associated 1	Homo sapiens	57-61
3838941-6	1985	Human manganese superoxide dismutase was also found to dismute the superoxide radical to hydrogen peroxide and water.	Water	111-116	superoxide dismutase 2	Homo sapiens	6-36
5762606-1	1969	As judged from the midpoints of the denaturation transition of 31 water-miscible alcohols, ureas, and amides, the effectiveness of these denaturing agents on sperm-whale myoglobin increases with increasing chain length and hydrocarbon content, as expected in view of the disorganization of the hydrophobic interior of this protein.	Water	66-71	myoglobin	Physeter catodon	170-179
13331607-0	1956	Use of coco-nut water in treatment of congestive cardiac failure.	Water	16-21	NUT midline carcinoma family member 1	Homo sapiens	12-15
3920663-0	1985	Intraventricular administration of cyclo(His-Pro), a metabolite of thyrotropin-releasing hormone (TRH), decreases water intake in the rat.	Water	114-119	thyrotropin releasing hormone	Rattus norvegicus	67-96
13218677-0	1954	[Inhalation experiments with P32-labelled Wiesbaden Kochbrunnen water in humans].	Water	64-69	inhibitor of growth family member 2	Homo sapiens	29-32
11946256-0	1968	- No Title - The blockage of the carboxyl groups of a pancreatic trypsin inhibitor (inhibitor of Kunitz) has been performed with a water-soluble carbodiimide and glycine ethyl ester.	Water	131-136	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	65-103
3920663-0	1985	Intraventricular administration of cyclo(His-Pro), a metabolite of thyrotropin-releasing hormone (TRH), decreases water intake in the rat.	Water	114-119	thyrotropin releasing hormone	Rattus norvegicus	98-101
4878010-0	1968	Gripe water.	Water	6-11	Ral GTPase activating protein catalytic subunit alpha 1	Homo sapiens	0-5
2982285-1	1985	Parathyroid hormone (PTH) and cAMP inhibit sodium, water, and bicarbonate reabsorption in the proximal tubule.	Water	51-56	parathyroid hormone	Oryctolagus cuniculus	0-19
6050548-0	1967	Water soluble contrast medium used as an aid in the therapeutic diagnosis of intestinal obstruction.	Water	0-5	activation induced cytidine deaminase	Homo sapiens	41-44
29009142-0	1934	The Mica Myth in Darjeeling Water.	Water	28-33	MHC class I polypeptide-related sequence A	Homo sapiens	4-8
2982285-1	1985	Parathyroid hormone (PTH) and cAMP inhibit sodium, water, and bicarbonate reabsorption in the proximal tubule.	Water	51-56	parathyroid hormone	Oryctolagus cuniculus	21-24
3999121-7	1985	MIP26-incorporated (but not control) vesicles swell under isotonic conditions indicating sucrose entry (via channels) followed by water to maintain osmotic balance.	Water	130-135	major intrinsic protein of lens fiber	Bos taurus	0-5
34051663-9	2021	Furthermore, nano-Cu, micro-Cu, and CuCl2.2 H2O upregulated the expression of the autophagy-related proteins, Beclin-1 and LC3 II/ LC3 I, and downregulated that of p62.	Water	44-47	beclin 1	Rattus norvegicus	110-118
34051663-9	2021	Furthermore, nano-Cu, micro-Cu, and CuCl2.2 H2O upregulated the expression of the autophagy-related proteins, Beclin-1 and LC3 II/ LC3 I, and downregulated that of p62.	Water	44-47	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	164-167
17821320-1	1961	Interstitial waters of Recent muds off Cape Cod have salinities higher than the present ocean water in the same location and pH values lower than normal sea water in equilibrium with the atmosphere.	Water	13-18	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	44-47
17821320-1	1961	Interstitial waters of Recent muds off Cape Cod have salinities higher than the present ocean water in the same location and pH values lower than normal sea water in equilibrium with the atmosphere.	Water	94-99	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	44-47
14456331-0	1961	[Activity of water-soluble adenosinetriphosphatase in transplanted tumors and in the spleen].	Water	13-18	ATPase Na+/K+ transporting subunit beta 1	Homo sapiens	27-50
6432777-2	1984	Modification of the three carboxyl groups on adrenodoxin using a water-soluble carbodiimide (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) caused a weakening of the binding of this iron-sulfur protein to both its electron donor protein, adrenodoxin reductase, and its electron acceptor protein, cytochrome P-450scc.	Water	65-70	ferredoxin reductase	Homo sapiens	238-259
14396343-0	1955	[The possibility of water fluoridation with natural calcium fluoride (CaF2)].	Water	20-25	CCR4-NOT transcription complex subunit 8	Homo sapiens	70-74
6466689-2	1984	The mechanism of action of hepatic triacylglycerol lipase (EC 3.1.1.3) was examined by comparing the hydrolysis of a water-soluble substrate, tributyrin, with that of triolein by hepatic triacylglycerol lipase purified from human post-heparin plasma.	Water	117-122	lipase C, hepatic type	Homo sapiens	27-57
6205158-3	1984	To determine the difference between the conformations, a protein (trypsin inhibitor) dissolved in water has been simulated using the method of molecular dynamics and the results are compared with those obtained from a simulation of the full crystalline unit cell.	Water	98-103	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	66-83
14885451-0	1951	Effects of renin on excretion of sodium, chloride and water in the rat.	Water	54-59	renin	Rattus norvegicus	11-16
6328535-0	1984	Effect of cAMP and calmodulin inhibitors on water absorption in rat proximal tubule.	Water	44-49	calmodulin 1	Rattus norvegicus	19-29
6328535-5	1984	The addition of either of two compounds with affinity for calmodulin, trifluoperazine (TFP) or W-13, reversed the cAMP-induced inhibition of water absorption.	Water	141-146	calmodulin 1	Rattus norvegicus	58-68
6328535-9	1984	These results demonstrate the presence of calmodulin in the kidney of the rat and suggest that calmodulin may be involved in cAMP-associated inhibition of water and electrolyte transport in the proximal tubule of the rat.	Water	155-160	calmodulin 1	Rattus norvegicus	42-52
6328535-9	1984	These results demonstrate the presence of calmodulin in the kidney of the rat and suggest that calmodulin may be involved in cAMP-associated inhibition of water and electrolyte transport in the proximal tubule of the rat.	Water	155-160	calmodulin 1	Rattus norvegicus	95-105
6724743-6	1984	It is likely that C3b or C3(H2O) was the previously unidentified anti-tumour factor activated in serum by S. aureus treatment or serum fractionation and described elsewhere.	Water	28-31	endogenous retrovirus group K member 3	Homo sapiens	18-21
6093165-1	1984	Disturbances in body water and electrolytes that trigger sodium appetite, such as sodium depletion or hypovolemia, are potent activators of the renin-angiotensin system.	Water	21-26	renin	Rattus norvegicus	144-149
6379988-3	1984	The purified connectin-like protein obtained had a rubbery appearance and was insoluble in water and immobile on SDS gel-electrophoresis.	Water	91-96	titin	Homo sapiens	13-22
6740235-6	1984	This will result in an increase in hydration of the mucin by the association of water molecules with the uncomplexed sialic acid molecules of the glycoproteins.	Water	80-85	LOC100508689	Homo sapiens	52-57
6661246-7	1983	The half-life of DES quinone in water was approximately 40 min; in methanol it was approximately 70 min.	Water	32-37	desmin	Rattus norvegicus	17-20
6141212-3	1983	Gel filtration (Sephadex G25) was more effective than dialysis against water in the removal of inhibitors of N-acetyl-beta-D-glucosaminidase and beta-glucuronidase.	Water	71-76	O-GlcNAcase	Rattus norvegicus	109-140
16663330-1	1983	The effects of water stress on nitrate reductase and nitrite reductase activities in symbiotic nodules were examined in field-grown soybean plants (Glycine max L Merr.	Water	15-20	inducible nitrate reductase [NADH] 1	Glycine max	31-48
6414881-1	1983	The hypothesis that thyrotropin-releasing hormone (TRH) affects salt and water transport in gastropod skin by means of altering the secretion of epithelial surface mucus was tested.	Water	73-78	thyrotropin releasing hormone	Homo sapiens	20-49
6578233-4	1983	This phenomenon may partially explain the observed reduction in caries for populations whose drinking water contains optimum levels of Sr at 5-10 mg/l and F at 1-2 mg/l.	Water	102-107	FAT atypical cadherin 1	Homo sapiens	155-163
6358461-15	1983	In conclusion, subcutaneous captopril causes increased water intake through activation of the renal renin-angiotensin system, an effect that is enhanced when the system has already been partly activated by ureteric ligation.	Water	55-60	renin	Rattus norvegicus	100-105
6309819-2	1983	Likewise, during net ATP hydrolysis by the Mg2+-activated chloroplast ATPase, the extent of water oxygen incorporation into each Pi released increases as the ATP, GTP, or ITP concentration is decreased.	Water	92-97	dynein axonemal heavy chain 8	Homo sapiens	70-76
6356172-6	1983	The alpha 2-adrenergic agonist, clonidine (6.25 micrograms/kg, SC), which suppresses renin release from the kidney, attenuated serotonin-induced water intake.	Water	145-150	renin	Rattus norvegicus	85-90
6307354-0	1983	The use of a water-soluble carbodiimide to cross-link cytochrome c to plastocyanin.	Water	13-18	LOC104968582	Bos taurus	54-66
6352282-3	1983	The compound 48/80-induced water intake seems to be mainly mediated by stimulation of the renin-angiotensin system.	Water	27-32	renin	Rattus norvegicus	90-95
16593332-11	1983	With added plastocyanin, ferredoxin, and ferredoxin-NADP(+) reductase, the inside-out vesicles enriched in PSII gave a significant photoreduction of NADP(+) with water as electron donor, under experimental conditions that appear to exclude the participation of PSI.	Water	162-167	ferredoxin reductase	Homo sapiens	41-69
6410971-9	1983	After TRH in group A, the mean (+/- SE) Pdct increased by 10 +/- 3 cm H2O (p less than 0.05) in study I and by 10 +/- 3 cm H2O (p less than 0.05) in study II whereas the mean compliance decreased by 37 +/- 20 ml/cm H2O (NS) in study I and by 44 +/- 18 ml/cm H2O (p less than 0.05) in study II.	Water	70-73	thyrotropin releasing hormone	Homo sapiens	6-9
34031970-3	2021	However, the extremely poor water solubility of CA4 hinders its biomedical applications.	Water	28-33	carbonic anhydrase 4	Mus musculus	48-51
6410971-9	1983	After TRH in group A, the mean (+/- SE) Pdct increased by 10 +/- 3 cm H2O (p less than 0.05) in study I and by 10 +/- 3 cm H2O (p less than 0.05) in study II whereas the mean compliance decreased by 37 +/- 20 ml/cm H2O (NS) in study I and by 44 +/- 18 ml/cm H2O (p less than 0.05) in study II.	Water	123-126	thyrotropin releasing hormone	Homo sapiens	6-9
6410971-9	1983	After TRH in group A, the mean (+/- SE) Pdct increased by 10 +/- 3 cm H2O (p less than 0.05) in study I and by 10 +/- 3 cm H2O (p less than 0.05) in study II whereas the mean compliance decreased by 37 +/- 20 ml/cm H2O (NS) in study I and by 44 +/- 18 ml/cm H2O (p less than 0.05) in study II.	Water	123-126	thyrotropin releasing hormone	Homo sapiens	6-9
6410971-9	1983	After TRH in group A, the mean (+/- SE) Pdct increased by 10 +/- 3 cm H2O (p less than 0.05) in study I and by 10 +/- 3 cm H2O (p less than 0.05) in study II whereas the mean compliance decreased by 37 +/- 20 ml/cm H2O (NS) in study I and by 44 +/- 18 ml/cm H2O (p less than 0.05) in study II.	Water	123-126	thyrotropin releasing hormone	Homo sapiens	6-9
33845472-10	2021	These results indicate that pH is a relevant parameter in green-synthesis protocols with the capability to control the nanoparticle"s geometry, and pave the way to computational studies exploring the effect of water monolayers on the adsorption of small molecules on wet gold surfaces.	Water	210-215	phenylalanine hydroxylase	Homo sapiens	28-30
17000438-3	1983	Following deposition of the monolayer or multilayer of Chl a or Chl b onto a plate, repetitive scans showed some modifications in the infrared spectra which are interpreted as a reorganization of the molecules as some water molecules leave the array.	Water	218-223	chordin like 1	Homo sapiens	55-58
33610988-1	2021	Characterized by high ammonium (NH4+ - N) and low ratio of chemical oxygen demand (COD) to total nitrogen (COD/TN), discharge of piggery wastewater has been identified as a primary pollution source resulting in water eutrophication.	Water	142-147	C-type lectin domain family 3 member B	Homo sapiens	111-113
17000438-3	1983	Following deposition of the monolayer or multilayer of Chl a or Chl b onto a plate, repetitive scans showed some modifications in the infrared spectra which are interpreted as a reorganization of the molecules as some water molecules leave the array.	Water	218-223	chordin like 1	Homo sapiens	64-67
34018189-8	2021	The gel structure and water holding capacity of MP/WG were improved by the cross-linking of TGase.	Water	22-27	transglutaminase 1	Homo sapiens	92-97
6348254-4	1983	The stimulating effect of renin on intake of water and hypertonic (2.7%) NaCl was continuous and persisted for at least a week after the largest (265 ng) dose of purified renin.3.	Water	45-50	renin	Rattus norvegicus	26-31
6348254-6	1983	A single preoptic injection of less than 0.75 pmol (26.5 ng) purified mouse renin caused mean intakes of 250.4 +/- 26.2 ml water and 44.8 +/- 12.5 ml 2.7% NaCl by five naive rats in 24 h. After the largest dose (265 ng) intakes of water and 2.7% NaCl reached about 80% and 20% body weight respectively.4.	Water	123-128	renin	Rattus norvegicus	76-81
34031621-4	2021	The binding affinity and the number of hot-spot residues of EG01377/NRP1 complex were higher than those of CendR and EG00229 systems, in line with the reported experimental data as well as with the lower water accessibility at the ligand-binding site.	Water	204-209	neuropilin 1	Homo sapiens	68-72
33689984-6	2021	FINDINGS: When the AFM tip passed through the water droplet surface, an attraction was observed due to capillary effects, such that the thickness of the water film was estimated and hence the profile of the droplet obtained.	Water	46-51	afamin	Homo sapiens	19-22
7159570-0	1982	Lipoprotein lipase catalyzed hydrolysis of water-soluble p-nitrophenyl esters.	Water	43-48	lipoprotein lipase	Bos taurus	0-18
33689984-6	2021	FINDINGS: When the AFM tip passed through the water droplet surface, an attraction was observed due to capillary effects, such that the thickness of the water film was estimated and hence the profile of the droplet obtained.	Water	153-158	afamin	Homo sapiens	19-22
33988981-7	2021	For the first time, we present a cocrystal structure of SAMHD1 with a substrate, Rp-dGTPalphaS, in which an Fe-Mg-bridging water species is poised for nucleophilic attack on the Palpha.	Water	123-128	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
34009575-5	2021	Furthermore, the NH4+-N and TN contents in the overlying water in the crab box were significantly higher than those of the control box, indicating that crab disturbances also had significant effects on the concentrations of NH4+-N, NO3--N, and TN in the overlying water.	Water	57-62	C-type lectin domain family 3 member B	Homo sapiens	28-30
34009575-6	2021	The existence of crab caves greatly promoted the nitrogen exchange flux at the sediment-water interface, and the mean exchange fluxes of NH4+-N, NO3--N and TN were 51.40 mmol (m2 day)-1, -13.44 mmol (m2 day)-1 and 39.74 mmol (m2 day)-1, respectively (much higher than those measured in the control box), implying that NH4+-N and TN were released from the sediment to the overlying water, while NO3--N was released from the overlying water to the sediment.	Water	88-93	C-type lectin domain family 3 member B	Homo sapiens	156-158
34009575-6	2021	The existence of crab caves greatly promoted the nitrogen exchange flux at the sediment-water interface, and the mean exchange fluxes of NH4+-N, NO3--N and TN were 51.40 mmol (m2 day)-1, -13.44 mmol (m2 day)-1 and 39.74 mmol (m2 day)-1, respectively (much higher than those measured in the control box), implying that NH4+-N and TN were released from the sediment to the overlying water, while NO3--N was released from the overlying water to the sediment.	Water	381-386	C-type lectin domain family 3 member B	Homo sapiens	156-158
34009575-6	2021	The existence of crab caves greatly promoted the nitrogen exchange flux at the sediment-water interface, and the mean exchange fluxes of NH4+-N, NO3--N and TN were 51.40 mmol (m2 day)-1, -13.44 mmol (m2 day)-1 and 39.74 mmol (m2 day)-1, respectively (much higher than those measured in the control box), implying that NH4+-N and TN were released from the sediment to the overlying water, while NO3--N was released from the overlying water to the sediment.	Water	381-386	C-type lectin domain family 3 member B	Homo sapiens	156-158
34059808-6	2021	18O- and 2H-labelling studies evidence the direct evolution of O2 through the nucleophilic attack of a H2O molecule on the highly electrophilic metal-oxo species via the formation of eta2-1iv-OO.	Water	103-106	DNA polymerase iota	Homo sapiens	183-187
7159570-2	1982	Bovine milk lipoprotein lipase (LpL) catalyzes the hydrolysis of the water-soluble esters p-nitrophenyl acetate (PNPA) and p-nitrophenyl butyrate (PNPB).	Water	69-74	lipoprotein lipase	Bos taurus	12-30
7159570-2	1982	Bovine milk lipoprotein lipase (LpL) catalyzes the hydrolysis of the water-soluble esters p-nitrophenyl acetate (PNPA) and p-nitrophenyl butyrate (PNPB).	Water	69-74	lipoprotein lipase	Bos taurus	32-35
34032448-1	2021	A striking dependence on the method of workup has been found for annulation of benzonitriles ArC N to N-methyl 2-toluamide (1), facilitated by n-BuLi (2 equiv): quenching the reaction by a slow addition of water produced the expected 1-isoquinolones 2; by contrast, slow pouring of the reaction mixture into water afforded the cyclic aminals 5 (retaining the NMe group of the original toluamide).	Water	206-211	activity regulated cytoskeleton associated protein	Homo sapiens	93-96
7159570-3	1982	The same protein and same active site are involved in hydrolysis of water-soluble p-nitrophenyl esters and emulsified trioleoylglycerol since (a) trioleoylglycerol hydrolysis and PNPB hydrolysis activities coelute from the heparin-Sepharose affinity column used to purify LpL and (b) LpL-catalyzed hydrolyses of trioleoylglycerol and PNPB are inhibited to equal extents by phenylmethanesulfonyl fluoride.	Water	68-73	lipoprotein lipase	Bos taurus	272-275
34032448-1	2021	A striking dependence on the method of workup has been found for annulation of benzonitriles ArC N to N-methyl 2-toluamide (1), facilitated by n-BuLi (2 equiv): quenching the reaction by a slow addition of water produced the expected 1-isoquinolones 2; by contrast, slow pouring of the reaction mixture into water afforded the cyclic aminals 5 (retaining the NMe group of the original toluamide).	Water	308-313	activity regulated cytoskeleton associated protein	Homo sapiens	93-96
7159570-3	1982	The same protein and same active site are involved in hydrolysis of water-soluble p-nitrophenyl esters and emulsified trioleoylglycerol since (a) trioleoylglycerol hydrolysis and PNPB hydrolysis activities coelute from the heparin-Sepharose affinity column used to purify LpL and (b) LpL-catalyzed hydrolyses of trioleoylglycerol and PNPB are inhibited to equal extents by phenylmethanesulfonyl fluoride.	Water	68-73	lipoprotein lipase	Bos taurus	284-287
33609931-4	2021	Long-term trends of bacterial concentrations and community structures were likely caused by changes in the water physical-chemical quality (i.e. pH and conductivity).	Water	107-112	phenylalanine hydroxylase	Homo sapiens	145-147
6757528-0	1982	The effect of water deprivation on the osmotic release of renin.	Water	14-19	renin	Rattus norvegicus	58-63
33609931-9	2021	On the other hand, FCM data correlated with water pH and conductivity, underlining the relation between physical-chemical and microbiological water quality.	Water	44-49	phenylalanine hydroxylase	Homo sapiens	50-52
33621846-5	2021	The content of water-stable macroaggregates (>=0.25 mm) increased by 8.3-35.0%, and the increase was the highest (35%) when biochar was applied at a rate of 30 t/ha 2) After applying biochar, the content of air-dried aggregates on the surface layer increased by 112.6-168.5%.	Water	15-20	dull endosperm 1	Zea mays	162-166
34027667-4	2021	The results from the molecular dynamics study shows that tozasertib-Aurora kinase A complex is stabilized through hydrogen bonding, polar interactions, and water bridges.	Water	156-161	aurora kinase A	Rattus norvegicus	68-83
6757528-1	1982	The effect of water deprivation on the osmotic release of renin was evaluated in conscious rats previously prepared with right nephrectomy and cannulations of left renal artery and lower abdominal aorta.	Water	14-19	renin	Rattus norvegicus	58-63
34029665-3	2021	The ability of thiolated hydroxypropyl-beta-cyclodextrin (HP- beta -CD-SH, 100 mM) to increase the water solubility of BUD (SHP- beta-CD-SH = 10.9 10-3 M) more than pristine hydroxypropyl- beta -cyclodextrin (HP- beta-CD, SHP- beta-CD = 4.3 10-3 M) has been previously demonstrated.	Water	99-104	nuclear receptor subfamily 0 group B member 2	Homo sapiens	124-127
6757528-6	1982	It is concluded that some intrarenal functional or structural change induced by water deprivation sensitizes the renin-secreting mechanism to colloid osmotic stimuli.	Water	80-85	renin	Rattus norvegicus	113-118
6127337-11	1982	In dark-maintained, thermally treated membranes, ATPase activity, i.e., the proton pump associated with it, also restored the lower level of acetic anhydride labeling, and again acetic anhydride no longer inhibited water oxidation.	Water	215-220	dynein axonemal heavy chain 8	Homo sapiens	49-55
33891402-2	2021	The polyanion of 1 can be described as a dimer of two similar trimers {(AsW9O33)3Dy2W5O12(H2O)6} that are linked by Dy cation and two mu2-oxo groups, and the Dy(III) ions in 1 are arranged in a linear fashion.	Water	90-93	adaptor related protein complex 1 subunit mu 2	Homo sapiens	134-137
33984041-6	2021	Hydrogen bonding, salt-bridge and water mediated interactions supported by MM-GBSA free energy of binding revealed strong binding of cordifolide A and sitoindoside IX to RdRP.	Water	34-39	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	170-174
6127337-12	1982	Because photosystem I activity did not elicit this type of response to acetic anhydride, there appears to be a pathway for ATPase pumped protons which allows them to reach a restricted domain, perhaps intramembrane, common with the photosystem II water oxidation mechanism and unavailable to protons pumped by photosystem I.	Water	247-252	dynein axonemal heavy chain 8	Homo sapiens	123-129
34030114-9	2021	Moreover, the HP4 PR adopted curled flap tip conformers which coordinated several water molecules into the active site in a manner that may reduce inhibitor binding affinity.	Water	82-87	defensin alpha 4	Homo sapiens	14-17
33963994-7	2021	Despite these influences, deoxygenation coefficient values were typical for clean water, and the reaeration coefficient findings show that the RGN is efficient at biological degradation of the organic matter even receiving untreated domestic sewage from riparian communities.	Water	82-87	regucalcin	Homo sapiens	143-146
6954312-2	1982	An enhancement of sevenfold to ninefold was seen in photoinduced cytotoxicity (by a colony-forming assay) and mutagenicity [at the hypoxanthine phosphoribosyltransferase (HPRT) locus] for cells pretreated with the process water compared to effects seen in cells exposed to sunlight only.	Water	222-227	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	131-169
6954312-2	1982	An enhancement of sevenfold to ninefold was seen in photoinduced cytotoxicity (by a colony-forming assay) and mutagenicity [at the hypoxanthine phosphoribosyltransferase (HPRT) locus] for cells pretreated with the process water compared to effects seen in cells exposed to sunlight only.	Water	222-227	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	171-175
33949124-3	2021	Our study comprises three steps: atom-by-atom generation of new molecules around a receptor, structural similarity mapping to existing approved and investigational drugs, and validation of their binding strengths to the viral spike proteins based on rigorous all-atom, explicit-water well-tempered metadynamics free energy calculations.	Water	278-283	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	226-231
6287253-3	1982	The hepatoma cells metabolized about 90% of 5 microM benzo[a]pyrene into water-soluble products within 24 h. Aryl hydrocarbon hydroxylase activity in huH-1 cells was induced to 24 times higher than the basal level by treatment with 13 microM benz[a]anthracene for 24 h. Metabolic activation of benzo[a]pyrene, dimethylnitrosamine and aflatoxin B1 by huH-1 cells was observed by cell-mediated sister-chromatid exchange assay.	Water	73-78	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	109-137
33950296-2	2021	The model has been expanded to study the effect of various pH by adding hydronium and hydroxide ions solvated by water molecules to the template-monomer system, to mimic acidic and basic environments, respectively.	Water	113-118	phenylalanine hydroxylase	Homo sapiens	59-61
33830743-1	2021	Although >700 disinfection byproducts (DBPs) have been identified, >50% of the total organic halogen (TOX) in drinking water chlorination is unknown, and the DBPs responsible for the chlorination-associated health risks remain largely unclear.	Water	119-124	thymocyte selection associated high mobility group box	Homo sapiens	102-105
33830743-3	2021	This raises a fascinating and important question: how much of the TOX and developmental toxicity of chlorinated drinking water can be attributed to aromatic halo-DBPs?	Water	121-126	thymocyte selection associated high mobility group box	Homo sapiens	66-69
6804102-7	1982	The mechanism behind the concentration of water-insoluble methyl sulphone and hydroxylated metabolites of triCB in an aquatic phase is discussed.	Water	42-47	MARVEL (membrane-associating) domain containing 2	Mus musculus	106-111
33660401-4	2021	AKAPs such as AKAP18, AKAP220, AKAP-Lbc and STUB1, and PDE4 coordinate arginine-vasopressin (AVP)-induced water reabsorption by collecting duct principal cells.	Water	106-111	A-kinase anchoring protein 7	Homo sapiens	14-20
33660401-4	2021	AKAPs such as AKAP18, AKAP220, AKAP-Lbc and STUB1, and PDE4 coordinate arginine-vasopressin (AVP)-induced water reabsorption by collecting duct principal cells.	Water	106-111	STIP1 homology and U-box containing protein 1	Homo sapiens	44-49
7070045-5	1982	The rubber IRP-1136, when contacting with dechlorinated tap water, alters its organoleptic and physico-chemical properties.	Water	60-65	Wnt family member 2	Homo sapiens	11-14
33429261-2	2021	Bi2S3@Ag2S heterojunction supported on surface of carbon fiber cloth (CC) are fabricated through hydrothermal in-situ growth method combined with ultrasonic loading strategy, which can be self-floated on water surface.	Water	204-209	angiotensin II receptor type 1	Homo sapiens	6-10
6132368-7	1982	Similarly, in the SSD procedure only post-training MIF markedly attenuated water intake on the day after training.	Water	75-80	macrophage migration inhibitory factor	Homo sapiens	51-54
33736588-7	2021	Extravascular lung water was correlated with total, conjugated, and unconjugated bilirubin and albumin (r = 0.342/P = .005; r = 0.338/ P = .005; r = 0.394/P = .001, and r = 0.358/P = .003) but not with aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and serum creatinine.	Water	19-24	glutamic--pyruvic transaminase	Homo sapiens	230-254
6132368-8	1982	In a separate experiment we have found that in the dose of 1.0 mg/kg, but not 0.1 mg/kg, MIF significantly inhibited water intake.	Water	117-122	macrophage migration inhibitory factor	Homo sapiens	89-92
33858963-8	2021	Maternal IgZ in zygotes showed a broad bacteriostatic activity to different microbes examined, and this reactivity can be manipulated by orchestrating desired bacteria in water where parent fish live or immunizing the parent fish through vaccination.	Water	171-176	immunoglobulin heavy constant tau	Danio rerio	9-12
7030085-9	1981	These results indicate that the hypotensive effect of water restriction in the two-kidney one-clip hypertensive rat model may be mediated, at least in part, through elevated circulating levels of vasopressin that subsequently inhibit renin release.	Water	54-59	renin	Rattus norvegicus	234-239
7323151-2	1981	It is shown that, due to the different water content of the various constituents of a blood cell suspension, the average dose D beta absorbed by a certain type of cells for a tritium nominal concentration Co and an irradiation time t is given by D beta(t) = KEnCo eta t. Typical values of the factor eta are calculated for lymphocytes.	Water	39-44	endothelin receptor type A	Homo sapiens	129-132
33197483-5	2021	Although S1pr2-/- mouse skin have no difference in its phenotype and barrier function compared to wildtype (wt), after tape stripping, S1pr2-/- mice showed significantly higher transepidermal water loss (TEWL) and required another 24 more hours to normalize their TEWL levels.	Water	192-197	sphingosine-1-phosphate receptor 2	Mus musculus	135-140
7323151-2	1981	It is shown that, due to the different water content of the various constituents of a blood cell suspension, the average dose D beta absorbed by a certain type of cells for a tritium nominal concentration Co and an irradiation time t is given by D beta(t) = KEnCo eta t. Typical values of the factor eta are calculated for lymphocytes.	Water	39-44	endothelin receptor type A	Homo sapiens	249-252
33264473-10	2021	Behaviorally induced defecation (caused by water avoidance stress) was reduced by the DRD2 antagonist, sulpiride.	Water	43-48	dopamine receptor D2	Homo sapiens	86-90
6168313-0	1981	Conformational properties of central nervous system myelin basic protein, beta-endorphin, and beta-lipotropin in water and in the presence of anionic lipids.	Water	113-118	myelin basic protein	Homo sapiens	52-72
6787052-2	1981	Colonic mucin was prepared by phenol-water partition extraction of th colonic mucosa, followed by ethanol precipitation of the water-soluble material, molecular sieve chromatography, and reductive sodium dodecyl sulfate-disc gel electrophoresis in an agarose-polyacrylamide gradient gel.	Water	37-42	LOC100508689	Homo sapiens	8-13
34025146-2	2021	The data procured from current investigation indicated that water stress significantly declined the plant growth, leaf area in addition to photosynthetic efficiency, nitrate reductase activity and crop yield at various stages of growth such as vegetative (VS), flowering (FS) and pod filling stage (PFS).	Water	60-65	inducible nitrate reductase [NADH] 1	Glycine max	166-183
33933518-4	2021	Here, we report on the in vitro and in vivo evaluation of a nano-encapsulated potent, but poorly water-soluble lead PNKP inhibitor, namely A83B4C63, as a new targeted therapeutic for PTEN-deficient CRC.	Water	97-102	polynucleotide kinase 3'- phosphatase	Mus musculus	116-120
6787052-2	1981	Colonic mucin was prepared by phenol-water partition extraction of th colonic mucosa, followed by ethanol precipitation of the water-soluble material, molecular sieve chromatography, and reductive sodium dodecyl sulfate-disc gel electrophoresis in an agarose-polyacrylamide gradient gel.	Water	127-132	LOC100508689	Homo sapiens	8-13
6941288-5	1981	In a glycerol/water mixture (eta = 180 centipoise) a concentration-dependent geminate recombination process is also seen.	Water	14-19	endothelin receptor type A	Homo sapiens	29-32
33900021-2	2021	We compare the coverage of two cases of water poisonings-one in a primarily-white town and the other in an Indigenous community-in 282 newspaper articles from the Toronto Star, the Globe and Mail, the National Post, and Windspeaker.	Water	40-45	steroidogenic acute regulatory protein	Homo sapiens	171-175
33900021-2	2021	We compare the coverage of two cases of water poisonings-one in a primarily-white town and the other in an Indigenous community-in 282 newspaper articles from the Toronto Star, the Globe and Mail, the National Post, and Windspeaker.	Water	40-45	NFKB inhibitor zeta	Homo sapiens	191-195
7460276-3	1981	For this reason, we developed an indirect assay for ionized magnesium in which Mg2+ is determined as the difference between ultrafiltrable magnesium, as measured in plasma water after ultracentrifugation, and complexed magnesium, as obtained after fixation of the ionized and protein-bound magnesium on Amberlite IR-120(H) cation-exchange resin.	Water	172-177	mucin 7, secreted	Homo sapiens	79-82
33997368-7	2021	Thus, Codonopsis Radix may regulate water and electrolytes homeostasis by affecting AT1R expression and aldosterone biosynthesis, possibly through downregulating SP1 and TEF transcription.	Water	36-41	angiotensin II receptor type 1	Homo sapiens	84-88
6259580-3	1981	Type Ib glycogen storage disease was suggested by the low normal activity of glucose-6-phosphatase (G-6-Pase) which reached 1.8 units/g (normal, 2 to 10 units/g) and the normal activity of other glycogenolytic enzymes, measured in homogenates prepared in H2O (mean +/- S.E.	Water	255-258	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	100-108
33919152-10	2021	In males, cold water swimming decreased PTH and PGE2 which resulted in a decrease in phosphorus content in bones (with no effect on bone density), an increase in 1,25-dihydroxyvitamin D3, and increase in T and GH, and may have positive consequences especially in bones and muscle tissue for the prevention of elderly sarcopenia.	Water	15-20	gamma-glutamyl hydrolase	Rattus norvegicus	210-212
6267562-5	1981	Unexpectedly, TRH (20 and 40 mg/kg, IP) potentiated the action of ethanol by increasing punished licking in water-deprived rats, rather than antagonizing this acute action of ethanol.	Water	108-113	thyrotropin releasing hormone	Rattus norvegicus	14-17
33707294-4	2021	Water deprivation for 24 hours caused greater increases in serum osmolality and losses in body weight in PLCdelta1 KO mice than it did in control mice.	Water	0-5	phospholipase C delta 1	Homo sapiens	105-114
6795619-0	1981	[Experimental studies for the hygienic standardization of Lasso in water].	Water	67-72	teneurin transmembrane protein 2	Rattus norvegicus	58-63
33874992-4	2021	We first tested Prdx6-/- mice on a Morris water maze task and found that their memory performance was defective, along with reduced long-term potentiation (LTP) in CA3-CA1 hippocampal synapses recorded from hippocampal sections of home-caged mice.	Water	42-47	peroxiredoxin 6	Mus musculus	16-21
6795619-5	1981	On the base of the experimental studies, differentiated hygienic norms (MAC) of lasso were elaborated in the three categories water-reservoirs - I mg/1 for I category and 5 mg/1 for II and II category.	Water	126-131	teneurin transmembrane protein 2	Rattus norvegicus	80-85
33857507-8	2021	As a result, CS-LLNEs film presented higher water vapor and oxygen barrier abilities and mechanical properties in comparison with CS-LL film.	Water	44-49	citrate synthase	Homo sapiens	13-15
7000955-1	1980	Rats given free access to food, water and 2.7% NaCl and injected with either renin or angiotensin II into the preoptic area showed an immediate increase in water intake followed by an increase in intake of 2.7% NaCl.	Water	156-161	renin	Rattus norvegicus	77-82
33868761-2	2021	Here, we present a Human Angiotensin-converting-enzyme 2 (ACE2)-functionalized gold "virus traps" nanostructure as an extremely sensitive SERS biosensor, to selectively capture and rapidly detect S-protein expressed coronavirus, such as the current SARS-CoV-2 in the contaminated water, down to the single-virus level.	Water	280-285	angiotensin converting enzyme 2	Homo sapiens	25-56
7000955-4	1980	However, the increased water intake during the 18 h after the administration of renin was reduced to normal levels in adrenalectomized rats.	Water	23-28	renin	Rattus norvegicus	80-85
33868761-2	2021	Here, we present a Human Angiotensin-converting-enzyme 2 (ACE2)-functionalized gold "virus traps" nanostructure as an extremely sensitive SERS biosensor, to selectively capture and rapidly detect S-protein expressed coronavirus, such as the current SARS-CoV-2 in the contaminated water, down to the single-virus level.	Water	280-285	angiotensin converting enzyme 2	Homo sapiens	58-62
7411436-2	1980	Intracranial injections of components of the renin-angiotensin system in rats in normal water and Na balance caused an immediate thirst followed by a progressive increase in Na appetite during a test session which lasted 18 h. The effect on water and Na intake was dose-dependent.	Water	88-93	renin	Rattus norvegicus	45-50
33836192-7	2021	While Fast diffusion and denaturation of SF on (NH4)2SO4 solution lead to the formation of microporous, water-unstable membrane SFM-2.	Water	104-109	cullin 4B	Homo sapiens	128-133
7411436-2	1980	Intracranial injections of components of the renin-angiotensin system in rats in normal water and Na balance caused an immediate thirst followed by a progressive increase in Na appetite during a test session which lasted 18 h. The effect on water and Na intake was dose-dependent.	Water	241-246	renin	Rattus norvegicus	45-50
508733-13	1979	The greatest action towards cytochrome b-559 photooxidation was obtained with the most active acceleration of the deactivation reactions of the water-splitting enzyme system Y agents: carbonylcyanide-p-trifluoromethoxyphenylhydrazone, ANT 2p and ANT 2s.	Water	144-149	uncharacterized protein	Chlamydomonas reinhardtii	235-241
33244811-6	2021	The obtained gel contains homogeneously dispersed star PNIPAAms as crosslinking points and exhibits thermoresponsive swelling behavior in water depending on the star contents.	Water	138-143	steroidogenic acute regulatory protein	Homo sapiens	50-54
33244811-6	2021	The obtained gel contains homogeneously dispersed star PNIPAAms as crosslinking points and exhibits thermoresponsive swelling behavior in water depending on the star contents.	Water	138-143	steroidogenic acute regulatory protein	Homo sapiens	161-165
33991463-1	2021	Functional interaction between the selective water channel AQP4 and several ion channels, such as TRPV4, NKCC1, and Na+ /K+ -ATPase, closely participate to regulate osmotic homeostasis.	Water	45-50	solute carrier family 12 member 2	Rattus norvegicus	105-110
546446-2	1979	Modification of pancreatic trypsin inhibitor by carboxymethyl dextran with the aid of carboxyl groups of the carrier activated by water-soluble carbodiimide has been carried out.	Water	130-135	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	27-44
33923302-8	2021	Prioritizing family mental health and functioning as a primary need that parallels that of accessing physical medical care, sanitation and clean water must be the definitive next step in humanitarian aid.	Water	145-150	activation induced cytidine deaminase	Homo sapiens	200-203
33967817-4	2021	CFS with 2% CS was selected based on the swelling degree, water absorption, and moisture retention.	Water	58-63	citrate synthase	Rattus norvegicus	12-14
33561713-5	2021	A framework is developed to aid in device selection by water and waste managers, which highlights the need for a watershed assessment, an understanding of site conditions, the attainment of community buy-in, and a long-term maintenance plan.	Water	55-60	activation induced cytidine deaminase	Homo sapiens	28-31
509413-2	1979	These cells contain aryl hydrocarbon hydroxylase (AHH) as determined by fluorescent measurements of water-soluble product from the metabolism of polycyclic aromatic hydrocarbons (PAH).	Water	100-105	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	20-48
33749067-7	2021	Both agonists stimulated colonic glass bead expulsion, and 5-HT4 LA1 activation stimulated fecal output and increased fecal water content.	Water	124-129	hypothermia due to alcohol sensitivity 4	Mus musculus	61-64
509413-2	1979	These cells contain aryl hydrocarbon hydroxylase (AHH) as determined by fluorescent measurements of water-soluble product from the metabolism of polycyclic aromatic hydrocarbons (PAH).	Water	100-105	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	50-53
157270-7	1979	Rats injected with 19-nor-DOCA and given water to drink showed enhanced growth and developed thymus enlargement and displayed hypokalemia and a reduction in both serum renin activity and corticosterone concentration.	Water	41-46	renin	Rattus norvegicus	168-173
33915921-2	2021	Due to the hot climate and intermittent water supply, the West Bank, Palestine, can be considered a high-risk area for this often fatal atypical pneumonia.	Water	40-45	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	63-67
504454-0	1979	Water intake and plasma renin activity of rats after intravenous infusions of rat renin.	Water	0-5	renin	Rattus norvegicus	82-87
33967458-8	2021	The results of the present study suggest that genetic manipulation of HSP90.2 homologs in other crops can offer promising leads to develop plant with better root biomass and architecture and improved agronomics traits, like better water and mineral absorption, salinity and drought tolerance potential.	Water	231-236	heat shock protein 90	Solanum lycopersicum	70-75
33924144-8	2021	A sensory analysis indicated that lupin cheese produced from PBA Jurien lupin milk using vinegar, 7.80% expressed as acetic acid, and ground in 45  C water, was the most acceptable.	Water	150-155	5'-nucleotidase, cytosolic IIIA	Homo sapiens	34-39
443387-8	1979	These data are interpreted to mean that the renin released into the incubation medium is inactivated at the air-water interface.	Water	112-117	renin	Rattus norvegicus	44-49
33872333-5	2021	HLp-nF1 treated rats showed improvements in fecal pellet number, weight, water content, intestinal transit length, and contractility compared to the constipation-induced rats.	Water	73-78	3-hydroxy-3-methylglutaryl-CoA lyase	Rattus norvegicus	0-3
33846238-2	2021	Experiments with nondiabetic HF rats tested the hypothesis that the SGLT2 inhibitor empagliflozin (EMPA) inhibits proximal tubule (PT) NHE3 activity and improves renal salt and water handling.	Water	177-182	solute carrier family 5 member 2	Rattus norvegicus	68-73
33869963-0	2021	Synthesis of FAU-Zeolite Membrane by a Secondary Growth Method: Influence of Seeding on Membrane Growth and Its Performance in the Dehydration of Isopropyl Alcohol-Water Mixture.	Water	164-169	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	13-16
33630985-1	2021	To establish how the hydrophobic surfactant proteins, SP-B and SP-C, promote adsorption of lipids to an air/water interface, we used X-ray diffuse scattering (XDS) to determine an order parameter of the lipid chains (Sxray) and the bending modulus of the lipid bilayers (KC).	Water	108-113	surfactant protein C	Bos taurus	63-67
475753-3	1979	For glucose 6-phosphate dehydrogenase, hexokinase and fumarase, enzyme activity became detectable (about 0.05% of the fully hydrated rate) when the water content was about 0.2g/g of reaction mixture, and for phosphoglucose isomerase, around 0.15g/g of reaction mixture.	Water	148-153	glucose-6-phosphate isomerase	Homo sapiens	208-232
33595294-3	2021	For the first time, CPAN precursors were screened by conducting formation potential (FP) tests on real water samples from six drinking water treatment plants (DWTPs).	Water	103-108	DNA fragmentation factor subunit beta	Homo sapiens	20-24
33595294-3	2021	For the first time, CPAN precursors were screened by conducting formation potential (FP) tests on real water samples from six drinking water treatment plants (DWTPs).	Water	135-140	DNA fragmentation factor subunit beta	Homo sapiens	20-24
33846438-9	2021	The results show that: (1) the annual runoff indicates an increasing trend in the future in contrast with the base period, while the ascending rate of the basin under RCP 4.5 is 4.47%; (2) a nonlinear relationship has been identified between the optimal allocation of water resources and water availability, while a linear association exists between the former and water demand; (3) increased water supply are needed in the water donor area, the middle and lower reaches should be supplemented with 4.495 billion m3 water in 2030.	Water	268-273	CGRP receptor component	Homo sapiens	167-170
33846438-9	2021	The results show that: (1) the annual runoff indicates an increasing trend in the future in contrast with the base period, while the ascending rate of the basin under RCP 4.5 is 4.47%; (2) a nonlinear relationship has been identified between the optimal allocation of water resources and water availability, while a linear association exists between the former and water demand; (3) increased water supply are needed in the water donor area, the middle and lower reaches should be supplemented with 4.495 billion m3 water in 2030.	Water	288-293	CGRP receptor component	Homo sapiens	167-170
33846438-9	2021	The results show that: (1) the annual runoff indicates an increasing trend in the future in contrast with the base period, while the ascending rate of the basin under RCP 4.5 is 4.47%; (2) a nonlinear relationship has been identified between the optimal allocation of water resources and water availability, while a linear association exists between the former and water demand; (3) increased water supply are needed in the water donor area, the middle and lower reaches should be supplemented with 4.495 billion m3 water in 2030.	Water	288-293	CGRP receptor component	Homo sapiens	167-170
33846438-9	2021	The results show that: (1) the annual runoff indicates an increasing trend in the future in contrast with the base period, while the ascending rate of the basin under RCP 4.5 is 4.47%; (2) a nonlinear relationship has been identified between the optimal allocation of water resources and water availability, while a linear association exists between the former and water demand; (3) increased water supply are needed in the water donor area, the middle and lower reaches should be supplemented with 4.495 billion m3 water in 2030.	Water	288-293	CGRP receptor component	Homo sapiens	167-170
33846438-9	2021	The results show that: (1) the annual runoff indicates an increasing trend in the future in contrast with the base period, while the ascending rate of the basin under RCP 4.5 is 4.47%; (2) a nonlinear relationship has been identified between the optimal allocation of water resources and water availability, while a linear association exists between the former and water demand; (3) increased water supply are needed in the water donor area, the middle and lower reaches should be supplemented with 4.495 billion m3 water in 2030.	Water	288-293	CGRP receptor component	Homo sapiens	167-170
33846438-9	2021	The results show that: (1) the annual runoff indicates an increasing trend in the future in contrast with the base period, while the ascending rate of the basin under RCP 4.5 is 4.47%; (2) a nonlinear relationship has been identified between the optimal allocation of water resources and water availability, while a linear association exists between the former and water demand; (3) increased water supply are needed in the water donor area, the middle and lower reaches should be supplemented with 4.495 billion m3 water in 2030.	Water	288-293	CGRP receptor component	Homo sapiens	167-170
33595294-12	2021	This study provides a powerful theoretical foundation for controlling CPAN formation in drinking water.	Water	97-102	DNA fragmentation factor subunit beta	Homo sapiens	70-74
33796071-2	2021	In particular, the degree of production and release of arginine vasopressin (AVP) in the hypothalamus is affected by plasma osmolality, and that hypothalamic AVP is responsible for thirst and osmolality-dependent water and metabolic balance.	Water	213-218	arginine vasopressin	Mus musculus	55-75
710591-2	1978	First, although administration of exogenous renin consistently increases water intake, the plasma renin activities that are produced seem to be outside of the normal physiological range when the elicited drinking is substantial.	Water	73-78	renin	Rattus norvegicus	44-49
33796071-2	2021	In particular, the degree of production and release of arginine vasopressin (AVP) in the hypothalamus is affected by plasma osmolality, and that hypothalamic AVP is responsible for thirst and osmolality-dependent water and metabolic balance.	Water	213-218	arginine vasopressin	Mus musculus	77-80
33796071-5	2021	Our immunohistochemical work shows that hypothalamic AVP cellular activity, as recognized by c-fos, was enhanced in parallel with an elevation in TonEBP expression within AVP cells following water deprivation.	Water	191-196	arginine vasopressin	Mus musculus	53-56
33689398-6	2021	An improved structure of the inactive kinase domain of WNK1, and a comparison with the structure of a monophosphorylated form of WNK1, suggests that large cavities, greater hydration, and specific bound water may participate in the osmosensing mechanism.	Water	203-208	WNK lysine deficient protein kinase 1	Homo sapiens	55-59
710591-3	1978	Second, although plasma renin activities are elevated following caval ligation, colloid, or isoproterenol treatment, this activity of the renin-angiotensin system appears to account for only a small portion of the observed water intake.	Water	223-228	renin	Rattus norvegicus	138-143
33689398-6	2021	An improved structure of the inactive kinase domain of WNK1, and a comparison with the structure of a monophosphorylated form of WNK1, suggests that large cavities, greater hydration, and specific bound water may participate in the osmosensing mechanism.	Water	203-208	WNK lysine deficient protein kinase 1	Homo sapiens	129-133
33144020-2	2021	Chitosan(CS), a biomaterial, has shown excellent results in water treatment.	Water	60-65	citrate synthase	Homo sapiens	9-11
81231-5	1978	In contrast, subcellular fractionation of water-lysed mast cells yielded arylsulfatase B with the heparin- and chymase-containing granule fraction and arylsulfatase A in the aqueous fraction comprised of cell sap and granule water eluate.	Water	42-47	arylsulfatase B	Rattus norvegicus	73-88
33916516-1	2021	The water-salt solutions of star-shaped six-arm poly-2-alkyl-2-oxazines and poly-2-alkyl-2-oxazolines were studied by light scattering and turbidimetry.	Water	4-9	steroidogenic acute regulatory protein	Homo sapiens	28-32
33620218-0	2021	Water-Soluble Near-Infrared Fluorescent Probes for Specific Detection of Monoamine Oxidase A in Living Biosystems.	Water	0-5	monoamine oxidase A	Mus musculus	73-92
153770-0	1978	[Inhibition of mitochondrial ATPase by water-soluble carbodiimide].	Water	39-44	ATP synthase F1 subunit epsilon	Homo sapiens	15-35
33687876-0	2022	Water Mapping and Scoring approaches to predict the role of Hydration sites in Binding Affinity of PAK1 inhibitors.	Water	0-5	p21 (RAC1) activated kinase 1	Homo sapiens	99-103
32557100-3	2021	This study was designed to test the hypothesis that exposure of mothers to Pb in drinking water may alter the expression of Clstn2 and Clstn3 in offspring, which contributes to the Pb-induced learning deficiency.	Water	90-95	calsyntenin 2	Mus musculus	124-130
412766-1	1977	The effect of TRH induced secretion of TSH and prolactin (hPrl) on plasma renin activity (PRA), water and electrolyte excretion, was studied in 7 normal males before and after an intravenous injection of 2 ml normal saline or 200 microgram TRH.	Water	96-101	thyrotropin releasing hormone	Homo sapiens	14-17
33517146-7	2021	While a 12-residue region of the CTP binds strongly to anionic bilayers containing phosphatidylserine lipids, the CTP termini fray from the membrane allowing for accommodation of the RIT1 globular domain at the membrane-water interface.	Water	220-225	Ras like without CAAX 1	Homo sapiens	183-187
576877-2	1977	The results showed that urine oxmolality rose progressively with increasing caloric concentration and was 78, 111, and 163 mOsm/kg H2O on 67, 80, and 100 kCal/dl SMA, respectively.	Water	131-134	survival of motor neuron 1, telomeric	Homo sapiens	162-165
32683650-3	2021	Member of the peroxisome proliferator-activated receptor (PPAR) family, especially PPARgamma agonists, has been well known for their insulin-sensitizing actions, but due to low water solubility, poor penetration into the brain and associated toxicity limit their use clinically.	Water	177-182	peroxisome proliferator activated receptor gamma	Mus musculus	83-92
851179-3	1977	(-)-Hydroxycitrate, and inhibitor of ATP citrate lyase, markedly reduced tritiated water incorporation into fatty acids by lung tissue slices.	Water	83-88	ATP citrate lyase	Rattus norvegicus	37-54
33898734-3	2021	This study was carried out to investigate how the social distancing measures could have influenced the Ibitinga reservoir"s water transparency in Sao Paulo State, Brazil.	Water	124-129	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	146-149
853971-5	1977	In mitochondria and bacteria the state of ordered water is identified with the energised state, which can be generated either by passage of electrons down the electron chain, or by ATPase activity.	Water	50-55	dynein axonemal heavy chain 8	Homo sapiens	181-187
33213908-5	2021	Special attention was given to the faecal indicator, Enterococcus spp., whose occurrence and antimicrobial resistance were tested in water and wastewater samples.	Water	133-138	histocompatibility minor 13	Homo sapiens	66-69
33833863-7	2021	In general, the use of a combination of acidifier and dextrose with the lowest dose, that is, 1 g/3.75 liters of drinking water can still give good results to Hen Day Production and Feed Conversion Ratio for laying hens infected with APEC.	Water	122-127	FCR	Gallus gallus	182-203
1017483-1	1976	The in vitro and in vivo activity of a new water soluble polyene antibiotic, anmed SPA-S-222, has been studied on numerous Candida and Cryptococcus species.	Water	43-48	surfactant associated protein A1	Mus musculus	83-86
33360547-4	2021	Following 7 days of water-sediment microcosm experiments, the levels of total nitroten (TN) and organic nitrogen (OrgN) were significantly increased by 50 mg/L Ag+ treatment when compared with the non-Ag control (P < 0.05).	Water	20-25	C-type lectin domain family 3 member B	Homo sapiens	88-90
821964-2	1976	The effect of TRH induced acute elevation of endogenous serum prolactin on renal water, sodium, potassium and total solute excretion was investigated during metabolic balance conditions and during escape form mineralocorticoid excess in 8 normal volunteers (6 males, 2 females)...	Water	81-86	thyrotropin releasing hormone	Homo sapiens	14-17
33082019-15	2021	The permeate streams of TR-BE-BW, TR-NE90-NF and BW30-RO membranes complied with the irrigation water standards in terms of EC, TDS and arsenic concentration while boron concentration remained above the allowable limit.	Water	96-101	BW30	Homo sapiens	49-53
1017417-9	1976	Furthermore, rats chronically exposed to 100 ppm paraquat in the water had elevated pulmonary activities of glucose-6-phosphate dehydrogenase and GSH reductase.	Water	65-70	glucose-6-phosphate dehydrogenase	Rattus norvegicus	108-141
776622-4	1976	Mild alkaline hydrolysis of the product gave three water-soluble phosphate esters which had the same electrophoretic mobilities as CMP, CDP-glycerol and glycerol 3-phosphate.	Water	51-56	cut like homeobox 1	Homo sapiens	136-139
131585-0	1976	[Proton transfer from water to octane coupled with the reaction of ATP hydrolysis by soluble ATPase from chloroplasts].	Water	22-27	dynein axonemal heavy chain 8	Homo sapiens	93-99
33436245-3	2021	Results indicated that introduction of SA could improve water retention capabilities of TN hydrogels.	Water	56-61	C-type lectin domain family 3 member B	Homo sapiens	88-90
131585-1	1976	It has been shown that soluble ATPase from chloroplasts adsorbed at the octane/water interface generates an ATP hydrolysis coupled potential charge (deltapi) at the interphase.	Water	79-84	dynein axonemal heavy chain 8	Homo sapiens	31-37
1249472-14	1976	In contrast, water reabsorption after BUL was slightly but significantly suppressed proximally (TF/Pin 1.95 +/- 0.02) and markedly depressed distally (TF/Pin 3.35 +/- 0.29).	Water	13-18	dynein light chain LC8-type 1	Rattus norvegicus	99-102
33025712-4	2021	The preparation of an artificial (synthetic) oral fluid (AOF) was conducted by dissolving its components (salts, surfactant, anti-microbial agent and mucin) in water.	Water	160-165	LOC100508689	Homo sapiens	150-155
1249472-14	1976	In contrast, water reabsorption after BUL was slightly but significantly suppressed proximally (TF/Pin 1.95 +/- 0.02) and markedly depressed distally (TF/Pin 3.35 +/- 0.29).	Water	13-18	dynein light chain LC8-type 1	Rattus norvegicus	154-157
33127052-0	2021	Enriched oxygen vacancies of Cu2O/SnS2/SnO2 heterostructure for enhanced photocatalytic reduction of CO2 by water and nitrogen fixation.	Water	108-113	sodium voltage-gated channel alpha subunit 11	Homo sapiens	34-38
33127052-2	2021	Herein, we formed a heterostructure between Cu2O and SnS2/SnO2 nanocomposite using a solvothermal reactor, which reduced CO2 by H2O at ambient conditions to produce CO, H2, and CH4.	Water	128-131	sodium voltage-gated channel alpha subunit 11	Homo sapiens	53-57
4020-0	1976	Interaction of hemopexin with water-soluble porphyrins.	Water	30-35	hemopexin	Homo sapiens	15-24
1192618-4	1975	These observations indicate that, at a critically high BP level, it is salt and water loss which, by activating the renin-angiotensin system, trigger the vicious circle of malignant renal hypertension in rats.	Water	80-85	renin	Rattus norvegicus	116-121
33334509-2	2021	To search for the new commercial sorbent and treatment strategy, an organic acrylic amine fiber (AAF) and phosphorus loading inorganic-organic AAF (P-AAF) were prepared and used for lead (Pb) removal from water.	Water	205-210	proteasomal ATPase associated factor 1	Homo sapiens	148-153
240032-8	1975	It is proposed that Mg2+ accelerates the splitting of the phosphate by favoring the conversion of the phosphoprotein from a state of low reactivity to a state of high reactivity towards water.	Water	186-191	mucin 7, secreted	Homo sapiens	20-23
33648537-14	2021	rCCL17 treatment decreased brain water content, attenuated short- and long-term neurological deficits, deceased activation of microglia/macrophages and infiltration of neutrophils, and inhibited neuronal apoptosis in the perihematomal region post-ICH.	Water	33-38	C-C motif chemokine ligand 17	Rattus norvegicus	0-6
129837-7	1975	Further, rats without growth hormone were determined to have a lower myocardial water content than rats with growth hormone.	Water	80-85	gonadotropin releasing hormone receptor	Rattus norvegicus	22-36
33718726-1	2021	This work reports a simple water-phase microwave method for the synthesis of water-soluble red emission Ag2S quantum dots at low temperatures without the need for an anaerobic process.	Water	27-32	angiotensin II receptor type 1	Homo sapiens	104-108
33718726-1	2021	This work reports a simple water-phase microwave method for the synthesis of water-soluble red emission Ag2S quantum dots at low temperatures without the need for an anaerobic process.	Water	77-82	angiotensin II receptor type 1	Homo sapiens	104-108
33718726-2	2021	It is worth noting that the prepared water-soluble Ag2S quantum dots enjoy positive water dispersion stability.	Water	37-42	angiotensin II receptor type 1	Homo sapiens	51-55
33718726-2	2021	It is worth noting that the prepared water-soluble Ag2S quantum dots enjoy positive water dispersion stability.	Water	84-89	angiotensin II receptor type 1	Homo sapiens	51-55
4724607-0	1973	The immobilization of beta-galactosidase through encapsulation in water-insoluble microcapsules.	Water	66-71	galactosidase beta 1	Homo sapiens	22-40
4697833-2	1973	Prevention of experimental allergic encephalomyelitis by a water-soluble spinal cord protein,   1 -SCP.	Water	59-64	solute carrier family 50 member 1	Homo sapiens	99-102
33560846-8	2021	Measured HNO profiles indicate that this component is formed directly by NH2 + HO2   HNO + H2O (R1b), but theoretical work indicates that R1b is only a minor channel.	Water	91-94	heme oxygenase 2	Homo sapiens	79-82
5019179-0	1972	Erythrocyte glutathione reductase activity and riboflavin concentration in experimental deficiency of some water soluble vitamins.	Water	107-112	glutathione-disulfide reductase	Homo sapiens	12-33
33668869-3	2021	Installed in laboratory long water-tube gauges allowing to determine the functions of tectonic activity-TAF, and their derivatives.	Water	29-34	TATA-box binding protein associated factor 8	Homo sapiens	104-107
4325461-9	1971	It is suggested that the actions of ovarian steroids on water and electrolyte metabolism might be due to increased activity of both the adrenal cortex and the renin-angiotensin system.	Water	56-61	renin	Rattus norvegicus	159-164
33570421-1	2021	The Kapitza resistance (Rk) at the water-carbon nanotube (CNT) interface, with water on the inside of the nanotube, was investigated using molecular dynamics simulations.	Water	35-40	ribokinase	Homo sapiens	4-27
33570421-1	2021	The Kapitza resistance (Rk) at the water-carbon nanotube (CNT) interface, with water on the inside of the nanotube, was investigated using molecular dynamics simulations.	Water	79-84	ribokinase	Homo sapiens	4-27
33570421-4	2021	Rk between the CNT and the confined water strongly depends on the diameter of the nanotube and is found to decrease with an increase in the CNT diameter, the opposite to what is reported in the literature when water is on the outside of the nanotube.	Water	36-41	ribokinase	Homo sapiens	0-2
33570421-4	2021	Rk between the CNT and the confined water strongly depends on the diameter of the nanotube and is found to decrease with an increase in the CNT diameter, the opposite to what is reported in the literature when water is on the outside of the nanotube.	Water	210-215	ribokinase	Homo sapiens	0-2
4325462-5	1971	renin into the angiotensin-sensitive region causes the water-replete rat to drink.	Water	55-60	renin	Rattus norvegicus	0-5
33570421-5	2021	Rk is furthermore found to converge to the planar graphene surface value as the number of water molecules per unit surface area approaches the value in the graphene surface and a higher overlap of the vibrational spectrum.	Water	90-95	ribokinase	Homo sapiens	0-2
4325462-7	1971	Synthetic tetradecapeptide renin substrate and angiotensin I were as effective as angiotensin II at causing water-replete rats to drink.4.	Water	108-113	renin	Rattus norvegicus	27-32
33744681-2	2021	Because of its high redox potential and ability to reduce oxygen directly to water, human ceruloplasmin, HCp, the only blue multicopper oxidase present in human plasma, appears to be the ultimate biocatalyst for oxygen biosensors and also biocathodes in biological power sources.	Water	77-82	coproporphyrinogen oxidase	Homo sapiens	105-108
4239805-0	1969	[Use of water-insoluble derivatives of the trypsin-kallikrein inhibitor for the isolation of kallikrein and plasmin].	Water	8-13	plasminogen	Homo sapiens	108-115
33594885-5	2021	The water vapor permeability of the HCS/KGM composite film was also improved significantly with the incorporation of beta-CD.	Water	4-9	holocarboxylase synthetase	Homo sapiens	36-39
5274763-0	1969	[Changes in the P32 and I-131 deposit in animals under the effect of water with various fluorine content].	Water	69-74	inhibitor of growth family member 2	Homo sapiens	16-19
33382083-2	2021	The proposed method aims at a more accurate conversion of CT Hounsfield Units (HU) into proton stopping power relative to water (SPR) to be used in proton-therapy treatment planning.	Water	122-127	sepiapterin reductase	Homo sapiens	129-132
33213921-4	2021	Exploring the complex relationships between water environment and landscape background, and Chl a concentration in the reservoir bays are crucial for ensuring high-quality drinking water from reservoirs.	Water	181-186	chordin like 1	Homo sapiens	92-95
33213921-9	2021	The net effect of water chemistry on Chl a concentration was more pronounced during the discharge period (total effect = 0.61, 37% of the total effect on Chl a), while the net effect of land-use composition on Chl a concentration was more significant during the storage period (total effect = 0.57, 30% of the total effect on Chl a).	Water	18-23	chordin like 1	Homo sapiens	37-40
33617397-6	2021	Conclusion: alpha-MSH treatment of EAU mediates a MC5r-dependent recovery of RPE suppression of phagolysosome activation in macrophages possibly altering antigen processing and presentation.	Water	35-38	melanocortin 5 receptor	Mus musculus	50-54
33669286-5	2021	The 22 neurosecretory cells (abdominal LK neurons, ABLKs) of the abdominal neuromeres co-express LK and a diuretic hormone (DH44), and together, these regulate water and ion homeostasis and associated stress as well as food intake.	Water	160-165	Diuretic hormone 44	Drosophila melanogaster	124-128
5700255-0	1968	[The concentration of K40 in the water and vegetables of irrigated areas of the Southern Ukraine].	Water	33-38	keratin 40	Homo sapiens	22-25
33475646-3	2021	Because the associated emission spectra were consistent with those of [Ir(tpy)2]Cl3 in water and [Ir(tpy)2](PF6)3 in the crystalline state, respectively, this dual emission is attributed to emissions from the [Ir(tpy)2]3+ cation and its ion pair [Ir(tpy)2]3+ PF6-.	Water	87-92	sperm associated antigen 17	Homo sapiens	259-262
32738166-1	2021	In the last two decades, environmental experts have focused on the development of several biological, chemical, physical and thermal methods/technologies for remediation of PAH polluted water.	Water	186-191	phenylalanine hydroxylase	Homo sapiens	173-176
32738166-5	2021	Water is an essential component of the ecosystem and highly susceptible to PAH contamination due to crude oil exploration and spillage, and improper municipal and industrial waste management, yet comprehensive reviews on PAH remediation are only available for contaminated soils, despite the several treatment methods developed for the remediation of PAH polluted water.	Water	0-5	phenylalanine hydroxylase	Homo sapiens	75-78
33443520-5	2021	Most strikingly, the strong blue light emission by nitrogen and sulfur co-doped carbon dots (N,S-CDs) could be encapsulated in 1 to generate a dual-emission composite, namely, N,S-CDs@Eu-MOF, which shows solvent-dependent photoluminescence: N,S-CD-related blue luminescence in water and Eu-MOF-related red emission in organic solvents.	Water	277-282	lysine acetyltransferase 8	Homo sapiens	187-190
13748680-0	1961	[Comparative studies on the effect of ADH, hypertensin and renin on the renal excretion of water and electrolytes in the rat].	Water	91-96	renin	Rattus norvegicus	59-64
33443520-5	2021	Most strikingly, the strong blue light emission by nitrogen and sulfur co-doped carbon dots (N,S-CDs) could be encapsulated in 1 to generate a dual-emission composite, namely, N,S-CDs@Eu-MOF, which shows solvent-dependent photoluminescence: N,S-CD-related blue luminescence in water and Eu-MOF-related red emission in organic solvents.	Water	277-282	lysine acetyltransferase 8	Homo sapiens	290-293
33557073-4	2021	cer3-6, a known Arabidopsis wax-deficient mutant (with distinct reduction in aldehydes, n-alkanes, secondary n-alcohols, and ketones compared to wild type (WT)), was most sensitive to water loss, while dewax, a known wax overproducer (greater alkanes and ketones compared to WT), was more resistant to dehydration compared to WT.	Water	184-189	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-6
33164127-12	2021	The effects of pH, Eh, and total suspended solids (TSS) on suspended Pd were reduced in the response process of the receiving water body.	Water	126-131	phenylalanine hydroxylase	Homo sapiens	15-17
33098181-7	2021	RESULTS: Histological analyses revealed that topical administration with EAP effectively attenuated dryness-like skin condition, including less percutaneous water loss rate, less infiltrate inflammation cells, and less epidermal thickening.	Water	157-162	glutamyl aminopeptidase	Homo sapiens	73-76
33115999-7	2021	SDR showed the lowest hygroscopic expansion of the four tested materials when immersed in deionized water and artificial saliva.	Water	100-105	caveolae associated protein 2	Homo sapiens	0-3
33563512-1	2021	We recently reported the fat fraction percentage of white adipose tissue in adolescents and adults measured by the water-fat separation method, but there was limited discussion about the change in adipose tissue fat fraction with growth.	Water	115-120	FAT atypical cadherin 1	Homo sapiens	25-28
33563512-1	2021	We recently reported the fat fraction percentage of white adipose tissue in adolescents and adults measured by the water-fat separation method, but there was limited discussion about the change in adipose tissue fat fraction with growth.	Water	115-120	FAT atypical cadherin 1	Homo sapiens	121-124
33563512-1	2021	We recently reported the fat fraction percentage of white adipose tissue in adolescents and adults measured by the water-fat separation method, but there was limited discussion about the change in adipose tissue fat fraction with growth.	Water	115-120	FAT atypical cadherin 1	Homo sapiens	121-124
33584618-0	2021	Antarctic Water Tracks: Microbial Community Responses to Variation in Soil Moisture, pH, and Salinity.	Water	10-15	phenylalanine hydroxylase	Homo sapiens	85-87
33481890-5	2021	Meanwhile, aquaculture water had high content of nitrogen, total phosphorus, chlorophyll a (Chl.a), total organic carbon (TOC), and chemical oxygen demand (COD).	Water	23-28	kelch domain containing 8B	Homo sapiens	92-95
33075589-8	2021	Plasma analyses showed that water-insoluble but not -soluble fraction of DEP increased circulating corticosterone and ACTH levels.	Water	28-33	pro-opiomelanocortin-alpha	Mus musculus	118-122
33356147-6	2021	It provides evidence that the reaction is dependent on hydride transfer to form an imine intermediate, which is subsequently hydrolyzed by a water molecule to produce l-Dap.	Water	141-146	death associated protein	Homo sapiens	169-172
33349474-11	2021	Meanwhile, 1, 2, 4, 5, and 6 significantly increased the expression of AQP3 protein (p < 0.05) to promote the excretion of water in the colon.	Water	123-128	aquaporin 3a	Danio rerio	71-75
33602214-11	2021	A 0.5 mg/L higher water fluoride level was associated with 34% higher relative risk of reporting sleeping less than the recommended duration for age [unweighted: RRR = 1.34, 95% CI: 1.03, 1.73; p = .026]; the relative risk was higher, though less precise, using survey-weighted data [RRR = 1.96, 95% CI: 0.99, 3.87; p = .05].	Water	18-23	dishevelled binding antagonist of beta catenin 3	Homo sapiens	162-169
33602214-11	2021	A 0.5 mg/L higher water fluoride level was associated with 34% higher relative risk of reporting sleeping less than the recommended duration for age [unweighted: RRR = 1.34, 95% CI: 1.03, 1.73; p = .026]; the relative risk was higher, though less precise, using survey-weighted data [RRR = 1.96, 95% CI: 0.99, 3.87; p = .05].	Water	18-23	dishevelled binding antagonist of beta catenin 3	Homo sapiens	284-291
33512170-4	2021	The achieved hybrid nanomaterial exhibited a low overpotential of 128 mV versus NHE at a current density of 10 mA cm-2 in the electrocatalytic water oxidation at pH 7.	Water	143-148	solute carrier family 9 member C1	Homo sapiens	80-83
33309854-7	2021	Furthermore, incubation of surfactant with an anti-SP-B antibody not only blocked membrane permeability but also affected lipid transfer into the air-water interface, as observed in a captive bubble surfactometer device.	Water	150-155	surfactant protein B	Homo sapiens	51-55
33475199-0	2021	Multiscale Assembly of [AgS4 ] Tetrahedrons into Hierarchical Ag-S Networks for Robust Photonic Water.	Water	96-101	G protein signaling modulator 3	Homo sapiens	24-28
31999938-10	2021	Moreover, miR-126 participated in the regulation of phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (Akt)/ glycogen synthase kinase-3beta (GSK-3beta) and extracellular signal-regulated kinase (ERK)1/2 signaling in EPCs, where both pathways were activated after miR-126 overexpression in H2O2-treated EPCs.	Water	294-298	glycogen synthase kinase 3 beta	Rattus norvegicus	114-144
31999938-11	2021	Overall, we showed that miR-126 promoted the biological function of EPCs under H2O2-induced oxidative stress by activating the PI3K/Akt/GSK-3beta and ERK1/2 signaling pathway, which may serve as a new therapeutic approach to treat AMI.	Water	79-83	glycogen synthase kinase 3 alpha	Rattus norvegicus	136-145
31999938-11	2021	Overall, we showed that miR-126 promoted the biological function of EPCs under H2O2-induced oxidative stress by activating the PI3K/Akt/GSK-3beta and ERK1/2 signaling pathway, which may serve as a new therapeutic approach to treat AMI.	Water	79-83	mitogen activated protein kinase 3	Rattus norvegicus	150-156
33416077-1	2021	This study investigated the effects of hot water extracts of 22 medicinal plants used traditionally to treat diabetes on Dipeptidyl peptidase-IV (DPP-IV) activity both in vitro and in vivo in high fat fed (HFF) obese-diabetic rats.	Water	43-48	dipeptidylpeptidase 4	Rattus norvegicus	121-144
33416077-1	2021	This study investigated the effects of hot water extracts of 22 medicinal plants used traditionally to treat diabetes on Dipeptidyl peptidase-IV (DPP-IV) activity both in vitro and in vivo in high fat fed (HFF) obese-diabetic rats.	Water	43-48	dipeptidylpeptidase 4	Rattus norvegicus	146-152
33487138-6	2021	Levels in domestic and public tap water were 4.57 +- 0.4 mg/L and 4.74 +- 0.8 mg/L, respectively.	Water	34-39	tracheal antimicrobial peptide	Bos taurus	30-33
33553942-5	2021	The SMG dispersion by blocking the dominant water pathway produced remaining oil areas that were difficult to be swept water flooding and then enlarged the swept volume.	Water	44-49	small nuclear ribonucleoprotein polypeptide G	Homo sapiens	4-7
33553942-5	2021	The SMG dispersion by blocking the dominant water pathway produced remaining oil areas that were difficult to be swept water flooding and then enlarged the swept volume.	Water	119-124	small nuclear ribonucleoprotein polypeptide G	Homo sapiens	4-7
33325709-6	2021	At relatively high polarization or pH, the limiting photoactivity shows a linear response to increasing photon flux and is attributed to a mechanism involving reduction of substrate water.	Water	182-187	phenylalanine hydroxylase	Homo sapiens	35-37
33389440-11	2022	The aptamer is also predicted to be non-antigenic, non-allergenic, non-hemolytic, non-inflammatory, water-soluble with high affinity toward ACE2 than serum albumin.	Water	100-105	angiotensin converting enzyme 2	Homo sapiens	140-144
32799138-2	2021	In this study, a new HMW framework was proposed, which divided the factors affecting coagulation into three parts consisting of hydraulic condition (H), metal salt (M), and background water matrix (W).	Water	184-189	cilia and flagella associated protein 97	Homo sapiens	21-24
32799138-8	2021	The ANN model was able to optimize the composition of the HMW framework improving the efficiency of DOM removal through the components of HMW such as velocity gradient (G value), coagulant dosage, solution pH, and background water matrix.	Water	225-230	cilia and flagella associated protein 97	Homo sapiens	58-61
33296998-8	2021	Thus, pH regulation is an environment-friendly and cost-effective method to remove Microcystis unicells, which can be potentially applied to water treatment.	Water	141-146	phenylalanine hydroxylase	Homo sapiens	6-8
33297034-2	2021	In this study, we reported an Ag coated membrane (PAN-Si-Cu-Ag) with a high catalytic activity to reduce 4-nitrophenol (4-NP) and methyl orange (MO) from water.	Water	154-159	adenosine deaminase 2	Homo sapiens	50-53
16654550-0	1953	Water-cooled Lamp Systems with Refluxing Aqueous Filters.	Water	0-5	lysosomal associated membrane protein 3	Homo sapiens	13-17
13081638-0	1952	[Nature of action and excretion of water soluble adenosinetriphosphatase in the kidneys].	Water	35-40	ATPase Na+/K+ transporting subunit beta 1	Homo sapiens	49-72
17770343-0	1949	Preparation of Radioautographs of Tissues without Loss of Water-Soluble P32.	Water	58-63	inhibitor of growth family member 2	Homo sapiens	72-75
34003715-6	2021	Likewise, SEB reported they were also significantly more likely to utilise massage (SEB 35, 59%, SDB 11, 29%, P = 0.001) and cold-water immersion (CWI) (SEB 28, 47%, SDB 10, 29%, P = 0.016) as recovery modes, compared to their SDB counterparts.	Water	130-135	SET binding protein 1	Homo sapiens	10-13
34023434-10	2021	We found that FGF-2 treatment effectively reduced the number of TUNEL-positive cells, decreased the brain water content, and improved the neurological function of rats after SAH.	Water	106-111	fibroblast growth factor 2	Rattus norvegicus	14-19
34020383-2	2021	In this work, a new kind of water-soluble RE-CDs nanocomposite (CDs@CaF2:Eu3+) was developed for the ratiometric determination of doxycycline (DOX).	Water	28-33	CCR4-NOT transcription complex subunit 8	Homo sapiens	68-72
33739584-1	2021	A novel charge-reversible surfactant, (CH 3 ) 2 N-(CH 2 ) 10 COONa, was designed and synthesized, which together with silica nanoparticles can stabilize a smart n -octane-in-water emulsion responsive to pH.	Water	174-179	phenylalanine hydroxylase	Homo sapiens	203-205
33524719-0	2021	Effect of pH and urea on the proteins secondary structure at the water/air interface and in solution.	Water	65-70	phenylalanine hydroxylase	Homo sapiens	10-12
33949520-4	2021	At a later time of the reaction, absorption bands of H2O and formyl chloride (CHClO) at 1782.9 cm-1 were observed; these species were likely produced from the secondary reactions of CH2ClO + O2   CHClO + HO2 and OH + HCl   H2O + Cl according to temporal profiles of CMHP, H2O, and CHClO; formation of CH2ClO + OH via decomposition of internally excited CMHP was predicted by theory and both HCl and O2 are major species in the system.	Water	53-56	heme oxygenase 2	Homo sapiens	204-207
33949520-4	2021	At a later time of the reaction, absorption bands of H2O and formyl chloride (CHClO) at 1782.9 cm-1 were observed; these species were likely produced from the secondary reactions of CH2ClO + O2   CHClO + HO2 and OH + HCl   H2O + Cl according to temporal profiles of CMHP, H2O, and CHClO; formation of CH2ClO + OH via decomposition of internally excited CMHP was predicted by theory and both HCl and O2 are major species in the system.	Water	223-226	heme oxygenase 2	Homo sapiens	204-207
33949520-4	2021	At a later time of the reaction, absorption bands of H2O and formyl chloride (CHClO) at 1782.9 cm-1 were observed; these species were likely produced from the secondary reactions of CH2ClO + O2   CHClO + HO2 and OH + HCl   H2O + Cl according to temporal profiles of CMHP, H2O, and CHClO; formation of CH2ClO + OH via decomposition of internally excited CMHP was predicted by theory and both HCl and O2 are major species in the system.	Water	223-226	heme oxygenase 2	Homo sapiens	204-207
34000322-6	2021	Behavioral experiments showed that homozygous ATRN rats spent significantly more time searching for the escape platform in the acquisition trial and significantly less time in the target area in the probe trial in the Morris water maze (MWM) test and traveled a significantly shorter distance in the open field test (OFT) than wild-type rats.	Water	225-230	attractin	Rattus norvegicus	46-50
33884795-7	2021	Compared with the catchment where traditional agricultural practices were followed, the agroforestry-water complex catchment effectively reduced the loss of nitrogen and decreased the first TN peak value and DN/TN and NN/DN values.	Water	101-106	C-type lectin domain family 3 member B	Homo sapiens	190-192
33297090-6	2021	Consequently, the formation of THM4, HAA9, HAN6, and TOX in the examined chlorinated water samples were reduced significantly.	Water	85-90	thymocyte selection associated high mobility group box	Homo sapiens	53-56
33585447-6	2020	Mitochondrial Ca2+ overload from the intracellular Ca2+-flux system located at the ER-mitochondrial axis can induce mitochondrial dilation during paraptosis, while the accumulation of misfolded proteins within the ER lumen is believed to exert an osmotic force and draw water from the cytoplasm to distend the ER lumen.	Water	270-275	epiregulin	Homo sapiens	83-85
33297090-7	2021	The maximum reduction in THM4 and TOX (66-69% and 61%, respectively) from wastewater effluent was achieved by the mixed resin system, which also reduced the THM4 and TOX by 77% and 77%, respectively, from raw source water.	Water	79-84	thymocyte selection associated high mobility group box	Homo sapiens	34-37
33884795-7	2021	Compared with the catchment where traditional agricultural practices were followed, the agroforestry-water complex catchment effectively reduced the loss of nitrogen and decreased the first TN peak value and DN/TN and NN/DN values.	Water	101-106	C-type lectin domain family 3 member B	Homo sapiens	208-213
33297090-7	2021	The maximum reduction in THM4 and TOX (66-69% and 61%, respectively) from wastewater effluent was achieved by the mixed resin system, which also reduced the THM4 and TOX by 77% and 77%, respectively, from raw source water.	Water	79-84	thymocyte selection associated high mobility group box	Homo sapiens	166-169
33932069-9	2021	What"s more, tumor promoting effect of NAXE knockdown in HCC xenograft can be abolished by giving mice NAC in drinking water.	Water	119-124	NAD(P)HX epimerase	Mus musculus	39-43
33521425-6	2021	Cellular uptake of the compounds 99mTc-Acdien-LHRH, Re-Acdien-LHRH, and Re-Acdien-peg-LHRH was found to be significantly enhanced compared to that of untargeted 99mTc alone and unlabeled [Re(CO)3(H2O)3]+.	Water	196-199	gonadotropin releasing hormone 1	Homo sapiens	46-50
33521425-6	2021	Cellular uptake of the compounds 99mTc-Acdien-LHRH, Re-Acdien-LHRH, and Re-Acdien-peg-LHRH was found to be significantly enhanced compared to that of untargeted 99mTc alone and unlabeled [Re(CO)3(H2O)3]+.	Water	196-199	gonadotropin releasing hormone 1	Homo sapiens	62-66
33521425-6	2021	Cellular uptake of the compounds 99mTc-Acdien-LHRH, Re-Acdien-LHRH, and Re-Acdien-peg-LHRH was found to be significantly enhanced compared to that of untargeted 99mTc alone and unlabeled [Re(CO)3(H2O)3]+.	Water	196-199	gonadotropin releasing hormone 1	Homo sapiens	62-66
33680469-10	2021	The architectural history of Casa Ippolito reveals how it supported its inhabitants" wellbeing in terms of shelter, water and food.	Water	116-121	casein alpha s1	Homo sapiens	29-33
33607352-2	2021	These wastes have created global issues in increasing the levels of BOD or COD in water as well as in soil or air segments.	Water	82-87	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	75-78
32830360-6	2021	We show that APH-1B adopts a 7TM topology with a water channel topology similar to APH-1A.	Water	49-54	aph-1 homolog B, gamma-secretase subunit	Homo sapiens	13-19
33325693-6	2021	Using these data, together with a bottom-up fuel-based inventory of vehicle emissions and volatile chemical products (FIVE-VCP) inventory, we identify tracer compounds for different VCP categories: decamethylcyclopentasiloxane (D5-siloxane) for personal care products, monoterpenes for fragrances, p-dichlorobenzene for insecticides, D4-siloxane for adhesives, para-chlorobenzotrifluoride (PCBTF) for solvent-based coatings, and Texanol for water-based coatings.	Water	441-446	valosin containing protein	Homo sapiens	182-185
33930030-6	2021	In septic syndecan-1 knockout mice, extravascular lung water content was higher, and early death was observed.	Water	55-60	syndecan 1	Mus musculus	10-20
32652421-5	2021	The removal performance assay found that MACS-NIL-Cu-lac had a good removal efficiency with 100.0 % for 2,4-dichlorophenol in water at 25  C, even when the concentration reached 50 mg/L.	Water	126-131	myristoylated alanine rich protein kinase C substrate	Homo sapiens	41-45
32830360-9	2021	This produces different accessibility of water molecules for the catalytic aspartates of PS1, critical for Abeta production.	Water	41-46	presenilin 1	Homo sapiens	89-92
32830360-11	2021	Our structural-dynamic model of APH-1B alone and in gamma-secretase suggests generally similar topology but some notable differences in water accessibility which may be relevant to the protein"s existence in two forms and their specific function and location.	Water	136-141	aph-1 homolog B, gamma-secretase subunit	Homo sapiens	32-38
33946988-4	2021	The hydrosols with MC water were characterized by a lower pH, decreased viscosity, a lower contact angle, and only slightly lower antioxidant activity than control samples.	Water	22-27	phenylalanine hydroxylase	Homo sapiens	58-60
33105135-0	2021	Syndecan-1 and Glypican-1 Knockout Alters Body Water Balance and Urine Response to Fluid Challenge in Mice.	Water	47-52	syndecan 1	Mus musculus	0-10
33105135-3	2021	Sdc-1 and Gpc-1 KO mice had higher starting blood water content versus strain-matched controls.	Water	50-55	syndecan 1	Mus musculus	0-5
33105135-4	2021	Sdc-1 KO mice exhibited a significantly higher diuretic response (87%; p < 0.05), higher excreted volume/infusion volume ratio (p < 0.01), higher extravascular/infused ratio, and greater tissue water concentration (60 vs. 52%).	Water	194-199	syndecan 1	Mus musculus	0-5
33389163-2	2021	The DFT (density functional theory)-B3LYP method coupled with 6-31G(d) basis set has been performed to investigate the optimized structures of transition states (TSs) and intermediates (IMs) of two processes in water: (i) the attack of 5"-deoxyadenosyl radical to complex PLP-L-lysine and (ii) hydrolysis to liberate L-beta-lysine.	Water	211-216	coiled-coil domain containing 177	Homo sapiens	272-277
33872010-3	2021	It is found that the vertical detachment energies (VDEs) of CaCl2(H2O)n-, CaBr2(H2O)n-, and CaI2(H2O)n- show a similar trend with increasing cluster size, while the VDEs of CaF2(H2O)n- show a different trend.	Water	66-69	CCR4-NOT transcription complex subunit 8	Homo sapiens	173-177
33401736-1	2021	Application of glass- or carbon-fiber-reinforced polymer (GFRP/CFRP) bars makes the direct use of seawater and sea sand concrete (SWSSC) in construction feasible, which is of high interest in order to conserve the limited resources of fresh water and river sand.	Water	101-106	GTP cyclohydrolase I feedback regulator	Homo sapiens	58-62
33108664-2	2021	Necroptosis occurs when mixed-lineage kinase domain-like protein (MLKL) punctures the cytoplasmic membrane allowing a rapid influx of water leading to a loss of cellular integrity.	Water	134-139	mixed lineage kinase domain like pseudokinase	Homo sapiens	24-64
33108664-2	2021	Necroptosis occurs when mixed-lineage kinase domain-like protein (MLKL) punctures the cytoplasmic membrane allowing a rapid influx of water leading to a loss of cellular integrity.	Water	134-139	mixed lineage kinase domain like pseudokinase	Homo sapiens	66-70
33252660-9	2020	Urine output and water intake of IRAP knockout mice were ~45% less than wildtype mice at late gestation.	Water	17-22	leucyl/cystinyl aminopeptidase	Mus musculus	33-37
33872010-4	2021	The VDEs of CaF2(H2O)n- are much lower than those of CaCl2(H2O)n-, CaBr2(H2O)n-, and CaI2(H2O)n-.	Water	17-20	CCR4-NOT transcription complex subunit 8	Homo sapiens	12-16
33872010-8	2021	However, in CaF2(H2O)n-/0, the Ca atom coordinates directly with only 2 or 3 H2O molecules.	Water	17-20	CCR4-NOT transcription complex subunit 8	Homo sapiens	12-16
33872010-8	2021	However, in CaF2(H2O)n-/0, the Ca atom coordinates directly with only 2 or 3 H2O molecules.	Water	77-80	CCR4-NOT transcription complex subunit 8	Homo sapiens	12-16
33932364-8	2021	The SSU rRNA sequence analysis revealed two animal-specific subtypes, including ST10 in cattle and sheep and ST14 in water buffaloes.	Water	117-122	suppressor of tumorigenicity 14 protein	Ovis aries	109-113
33312878-1	2020	The biotinidase (BTD) enzyme is essential for recycling biotin, a water-soluble B-complex vitamin that is the coenzyme of four carboxylases involved in fatty acid synthesis, amino acid catabolism and gluconeogenesis.	Water	66-71	biotinidase	Homo sapiens	4-15
33569432-10	2021	Exposure to glyphosate alone or glyphosate plus hard water increased the levels of oxidative stress markers and inflammatory biomarkers, namely, thromboxane A2 (TX-A2), leukotriene B4 (LTB4), prostaglandin E2 (PGE2), nitric oxide synthase (NOS), and nitric oxide (NO).	Water	53-58	nitric oxide synthase 1, neuronal	Mus musculus	217-238
33569432-13	2021	Conclusions: These findings suggested that hard water combined with glyphosate can induce renal tubular injury in mice, and this may involve mitogen-activated protein kinases (MAPK)/cytosolic phospholipase A2 (cPLA2)/arachidonic acid (AA) and its downstream factors.	Water	48-53	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	182-208
33569432-13	2021	Conclusions: These findings suggested that hard water combined with glyphosate can induce renal tubular injury in mice, and this may involve mitogen-activated protein kinases (MAPK)/cytosolic phospholipase A2 (cPLA2)/arachidonic acid (AA) and its downstream factors.	Water	48-53	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	210-215
33925363-1	2021	Inquiries into the participation of short hydrogen bonds in stabilizing transition states and intermediate states in the thrombin, factor Xa, plasmin and activated protein C-catalyzed reactions revealed that specific binding of effectors at Sn, n = 1-4 and S"n, n = 1-3 and at remote exosites elicit complex patterns of hydrogen bonding and involve water networks.	Water	349-354	plasminogen	Homo sapiens	142-149
32820436-4	2021	PAH contamination was observed slightly lower in the summer season from the pollution characteristics of water bodies in most areas of the Baiyangdian Lake, and the levels of PAH pollution in the water body of urban residential regions and rural residential regions were relatively higher than those in tourist regions and low human disturbance regions.	Water	105-110	phenylalanine hydroxylase	Homo sapiens	0-3
32820436-4	2021	PAH contamination was observed slightly lower in the summer season from the pollution characteristics of water bodies in most areas of the Baiyangdian Lake, and the levels of PAH pollution in the water body of urban residential regions and rural residential regions were relatively higher than those in tourist regions and low human disturbance regions.	Water	196-201	phenylalanine hydroxylase	Homo sapiens	175-178
33273142-0	2020	Removing the C-terminal protecting group enlarges the crystal size: Z-(Gly-Aib)2-OH H2O.	Water	84-87	ANIB2	Homo sapiens	75-80
31903787-9	2020	In addition, HYP decreased the production of phosphorylated Jun N-terminal kinase (JNK) and p38 levels of osteoblastic MC3T3-E1 cells induced by H2O2.	Water	145-149	mitogen-activated protein kinase 14	Mus musculus	92-95
33997408-2	2021	Although numerous chemical species such as water soluble ionic species (e.g. Na+, K+, Cl-, Ca2+, Mg2+) and acid leachable heavy metal fractions (e.g. Fe, Cd, Al, Mo, Sb, As, Cu, Zn, Pb, and Mn) can be used to characterize tsunami deposits, the knowledge of PAH congeners as alternative chemical species for identifying tsunami backwash deposits is strictly limited.	Water	43-48	phenylalanine hydroxylase	Homo sapiens	257-260
33989927-7	2021	We probed water adsorption in mica pores from which disjoining pressure, grand potential (swelling free energy), and structural properties of confined water and ions were calculated.	Water	10-15	MHC class I polypeptide-related sequence A	Homo sapiens	30-34
32976971-10	2020	This could prevent the binding of the second substrate in the right orientation and results in the preferential transfer of the acetyl group to water, thus exhibiting hydrolase rather than transferase activity.	Water	144-149	transferase	Mycobacterium tuberculosis H37Rv	189-200
33406451-4	2021	The valance band and conduction band of the synthesized semiconductor were also positioned appropriately (w.r.t NHE) so that the required redox reactions with water in presence of the photogenerated excitons are facilitated.	Water	159-164	solute carrier family 9 member C1	Homo sapiens	112-115
33260659-2	2020	Amongst a variety of parameters such as level (or depth), temperature, conductivity, turbidity, and pH, the water level is the most fundamental one that needs to be monitored on a real-time basis for securing the water management system.	Water	108-113	phenylalanine hydroxylase	Homo sapiens	100-102
33185198-0	2020	Molecular level picture of the interplay between pH and phosphate binding at the goethite-water interface.	Water	90-95	phenylalanine hydroxylase	Homo sapiens	49-51
33508402-7	2021	The data obtained from this study showed that the use of miR mimic and Q10 increased the level of miR-149, decreased the extent of neurological defects and tissue damage, increased BBB integrity, decreased brain water percentage and also decreased the level of inflammatory cytokines and MMPs.	Water	212-217	matrix metallopeptidase 2	Rattus norvegicus	288-292
33185198-3	2020	The target of the current contribution is to draw a molecular level picture of the interplay between pH and phosphate binding at the goethite-water interface via a joint experimental-theoretical approach.	Water	142-147	phenylalanine hydroxylase	Homo sapiens	101-103
33058832-1	2020	Aquaporin 1 (AQP1), a transmembrane protein that forms water channels, has previously been shown to facilitate growth and progression of many types of tumors by modulating tumor cell migration, proliferation and angiogenesis.	Water	55-60	aquaporin 1	Mus musculus	0-11
33058832-1	2020	Aquaporin 1 (AQP1), a transmembrane protein that forms water channels, has previously been shown to facilitate growth and progression of many types of tumors by modulating tumor cell migration, proliferation and angiogenesis.	Water	55-60	aquaporin 1	Mus musculus	13-17
32767676-7	2021	Superficial to mid (0-60% depth) cartilage CA4+ partitions correlated with water content (R<-0.521, p<0.05), whereas in deeper (40-100%) cartilage, CA4+ correlated only with proteoglycans (R>0.671, p<0.01).	Water	75-80	carbonic anhydrase 4	Homo sapiens	43-46
32937706-6	2020	Meanwhile, the EP/BP-RGO2.0 nanocomposites exhibited satisfying air stability even after being immersed in water for a month.	Water	107-112	epiregulin	Homo sapiens	15-20
33358303-1	2021	Aquaporin 1 (AQP1) is the archetype of all aquaporins and involved in rapid cellular water fluxes and cell volume regulation.	Water	85-90	aquaporin 1	Rattus norvegicus	0-11
32721743-5	2020	Precipitation >30.0 mm d-1 recharged the shallow groundwater by piston flow when the water table in the check dam was <4.0 m. When the water table varied from the head (>4.0 m) to the middle and tail (<4.0 m) of the check dam, the influx of precipitation was by runoff in the catchment above the trench head, replenishing the groundwater vertically through the trench head and then moving laterally underground to the end of the dam.	Water	55-60	leiomodin 1	Homo sapiens	23-26
32721743-5	2020	Precipitation >30.0 mm d-1 recharged the shallow groundwater by piston flow when the water table in the check dam was <4.0 m. When the water table varied from the head (>4.0 m) to the middle and tail (<4.0 m) of the check dam, the influx of precipitation was by runoff in the catchment above the trench head, replenishing the groundwater vertically through the trench head and then moving laterally underground to the end of the dam.	Water	85-90	leiomodin 1	Homo sapiens	23-26
33358303-1	2021	Aquaporin 1 (AQP1) is the archetype of all aquaporins and involved in rapid cellular water fluxes and cell volume regulation.	Water	85-90	aquaporin 1	Rattus norvegicus	13-17
33506506-1	2021	Brain water and some critically important energy metabolites, such as lactate or glucose, are present in both intracellular and extracellular spaces (ICS/ECS) at significant levels.	Water	6-11	epistatic circling SWR/J	Mus musculus	154-157
33194517-5	2020	We fabricated HAp nanoparticles using the water-in-oil (W/O) emulsion method and used these nanoparticles as the delivery vector for transfecting cardiomyocyte-derived HL-1 cells.	Water	42-47	reticulon 3	Homo sapiens	14-17
33251259-0	2020	Polymorphisms in TLR4 Gene Associated With Somatic Cell Score in Water Buffaloes (Bubalus bubalis).	Water	65-70	toll-like receptor 4	Bubalus bubalis	17-21
33751889-9	2021	We attribute the surface PCET and stability to the presence of a water ligand in the coordination sphere of immobilized Ru-Cat1 and Ru-Cat2 which can H-bond with negatively charged carboxylate groups of the cross-linked PAA brushes.	Water	65-70	solute carrier family 7 member 2	Homo sapiens	135-139
32768841-5	2020	We have demonstrated that the top and bottom CNCs-coated TEMPO-CNF substrates (CNC/TEMPO-CNF/CNC) have excellent mechanical and good water vapor barrier properties.	Water	133-138	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	45-48
32768841-5	2020	We have demonstrated that the top and bottom CNCs-coated TEMPO-CNF substrates (CNC/TEMPO-CNF/CNC) have excellent mechanical and good water vapor barrier properties.	Water	133-138	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	83-96
33994109-9	2021	Gene analysis showed higher expression of the adipocyte markers aP2 and GLUT4 in the adipocyte-differentiated water jet cell preparations, and ELISA indicated increased secretion of adiponectin from these cells.	Water	110-115	solute carrier family 2 member 4	Homo sapiens	72-77
32768841-6	2020	The resulting CNC/TEMPO-CNF/CNC films revealed a high tensile strength of 114 MPa and a low specific water vapor transmission rate (SWVTR) of 19 g mm/m2 day.	Water	101-106	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	14-17
32768841-6	2020	The resulting CNC/TEMPO-CNF/CNC films revealed a high tensile strength of 114 MPa and a low specific water vapor transmission rate (SWVTR) of 19 g mm/m2 day.	Water	101-106	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	28-31
32768841-7	2020	In addition, the CNC/TEMPO-CNF/CNC films were resistant to various solvents including water, ethanol, tetrahydrofuran (THF), and acetone.	Water	86-91	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	17-20
32768841-7	2020	In addition, the CNC/TEMPO-CNF/CNC films were resistant to various solvents including water, ethanol, tetrahydrofuran (THF), and acetone.	Water	86-91	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	31-34
33169164-2	2021	In this study, we focused on HvPIP1; 2, a PIP1 in barley (Hordeum vulgare), to dissect the molecular mechanisms that evoke HvPIP1-mediated water transport.	Water	139-144	HvPIP1;2	Hordeum vulgare	29-38
32889694-8	2020	However, the Morris water maze test uncovered a deficit in spatial learning and memory in TPC1-/- mice.	Water	20-25	two pore channel 1	Mus musculus	90-94
33135143-3	2021	The static simulation method and related analysis techniques were used to explore the release characteristics of different forms of inorganic nitrogen and its effect on TN and Chla in overlying water from the different water layers.	Water	194-199	C-type lectin domain family 3 member B	Homo sapiens	169-171
33169164-9	2021	These data provided evidence that the HvPIP1; 2 molecule has own water transport activity and an interaction with the middle part of the HvPIP2; 4 protein (except for the N- and C- termini) is required for HvPIP1; 2 functionality as water channel.	Water	65-70	HvPIP1;2	Hordeum vulgare	38-47
33135143-8	2021	NO3--N in sediments was the main contributor of TN and Chla changes in the overlying water and its content can reflect the nitrogen pollution trend of the water body to a certain extent.	Water	85-90	C-type lectin domain family 3 member B	Homo sapiens	48-50
33135143-8	2021	NO3--N in sediments was the main contributor of TN and Chla changes in the overlying water and its content can reflect the nitrogen pollution trend of the water body to a certain extent.	Water	155-160	C-type lectin domain family 3 member B	Homo sapiens	48-50
33169164-9	2021	These data provided evidence that the HvPIP1; 2 molecule has own water transport activity and an interaction with the middle part of the HvPIP2; 4 protein (except for the N- and C- termini) is required for HvPIP1; 2 functionality as water channel.	Water	65-70	HvPIP1;2	Hordeum vulgare	206-215
33169164-9	2021	These data provided evidence that the HvPIP1; 2 molecule has own water transport activity and an interaction with the middle part of the HvPIP2; 4 protein (except for the N- and C- termini) is required for HvPIP1; 2 functionality as water channel.	Water	233-238	HvPIP1;2	Hordeum vulgare	38-47
33169164-9	2021	These data provided evidence that the HvPIP1; 2 molecule has own water transport activity and an interaction with the middle part of the HvPIP2; 4 protein (except for the N- and C- termini) is required for HvPIP1; 2 functionality as water channel.	Water	233-238	HvPIP1;2	Hordeum vulgare	206-215
33127873-1	2020	BACKGROUND Our study aims to investigate the role of segmental multi-frequency bioelectrical impedance analysis (SMF-BIA) in the monitoring of upper limb water changes of patients with breast cancer before and after surgery to aid in establishing a new approach to preventing lymphedema.	Water	154-159	activation induced cytidine deaminase	Homo sapiens	227-230
33268258-3	2021	Spiking the porcine epidemic diarrhea virus (PEDV), an enveloped virus surrogate for SARS-CoV-2, together with the mengovirus, we demonstrated that PEG-precipitation and SENS-kit better recovered PEDV (13.10 +- 0.66%) from tap water, while centrifugal filtration resulted the best option to recover mengovirus regardless of the detection kit used.	Water	227-232	potassium channel tetramerization domain containing 1	Homo sapiens	170-174
33073268-0	2020	Retraction: Water-soluble multidentate polymers compactly coating Ag2S quantum dots with minimized hydrodynamic size and bright emission tunable from red to second near-infrared region.	Water	12-17	angiotensin II receptor type 1	Homo sapiens	66-70
33073268-1	2020	Retraction of "Water-soluble multidentate polymers compactly coating Ag2S quantum dots with minimized hydrodynamic size and bright emission tunable from red to second near-infrared region" by Rijun Gui et al., Nanoscale, 2014, 6, 5467-5473, DOI: 10.1039/C4NR00282B.	Water	15-20	angiotensin II receptor type 1	Homo sapiens	69-73
33348098-0	2021	Presence of fluoride in water diminishes fast the SPR peak of silver nanocrystals showing large red shift with quick sedimentation - A fast sensing and fast removal case.	Water	24-29	sepiapterin reductase	Homo sapiens	50-53
32503021-2	2020	Here, we propose a high-resolution nanoscale patterning method based on field-emission scanning probe lithography (FE-SPL) that crosslinks the biomaterial silk on conductive indium tin oxide promoting the use of a biodegradable material as resist and water as a developer.	Water	251-256	sphingosine-1-phosphate lyase 1	Homo sapiens	118-121
32993285-0	2020	Competition between Solvent-Solvent and Solvent-Solute Interactions in the Microhydration of the Hexafluorophosphate Anion, PF6-(H2O)n=1,2.	Water	129-132	sperm associated antigen 17	Homo sapiens	124-127
33713045-1	2021	In vertebrates, the mineralocorticoid receptor (MR) is a steroid-activated nuclear receptor (NR) that plays essential roles in water-electrolyte balance and blood pressure homeostasis.	Water	127-132	nuclear receptor subfamily 3 group C member 2	Homo sapiens	20-46
32993285-1	2020	This study systematically examines the interactions of the hexafluorophosphate anion (PF6-) with one or two solvent water molecules (PF6-(H2O)n where n = 1, 2).	Water	116-121	sperm associated antigen 17	Homo sapiens	86-89
32993285-3	2020	Five new stationary points of PF6-(H2O)2 have been identified, one of which has an electronic energy of approximately 2 kcal mol-1 lower than the only other dihydrate structure reported for this system.	Water	35-38	sperm associated antigen 17	Homo sapiens	30-33
32993285-4	2020	The CCSD(T) computations also reveal that the detailed interactions between PF6- and H2O can be quite difficult to model reliably, with some methods struggling to correctly characterize stationary points for n = 1 or accurately reproduce the vibrational frequency shifts induced by the formation of the hydrated complex.	Water	85-88	sperm associated antigen 17	Homo sapiens	76-79
32993285-5	2020	Although the interactions between the solvent and ionic solute are quite strong (CCSD(T) electronic dissociation energy  10 kcal mol-1 for the monohydrate minimum), the solvent-solvent interactions in the lowest-energy PF6-(H2O)2 minimum give rise to appreciable cooperative effects not observed in the other dihydrate minima.	Water	224-227	sperm associated antigen 17	Homo sapiens	219-222
33069055-0	2021	Discovery of heterocycle-containing alpha-naphthoflavone derivatives as water-soluble, highly potent and selective CYP1B1 inhibitors.	Water	72-77	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	115-121
33202247-5	2021	Consistent with previous work, loss of AVP signaling increases water consumption and accelerates recovery to simulated jetlag.	Water	63-68	arginine vasopressin	Mus musculus	39-42
33713045-1	2021	In vertebrates, the mineralocorticoid receptor (MR) is a steroid-activated nuclear receptor (NR) that plays essential roles in water-electrolyte balance and blood pressure homeostasis.	Water	127-132	nuclear receptor subfamily 3 group C member 2	Homo sapiens	48-50
33650064-1	2022	The current study aimed to identify correlative and regressive dependencies between the water iodine concentration and the levels of TSH (thyroid-stimulating hormone), thyroglobulin antibodies (TgAbs), and thyroid peroxidase (TPOAb) in the serum of 168 in patients (34 men and 134 women) with a hypothyroid form of Hashimoto"s thyroiditis who use water from the supply network and individual wells.	Water	88-93	thyroglobulin	Homo sapiens	168-181
34019472-4	2021	Results demonstrated that Ki67 immunoexpression was higher in hepatocytes exposed to both sampling site, while caspase-3 demonstrated downregulation in rat liver exposed to estuarine water.	Water	183-188	caspase 3	Rattus norvegicus	111-120
33047747-7	2020	Furthermore, the photocatalytic performance indicates that the hBP-XMY (M = Mo, W; (X   Y) = S, Se, Te) vdW heterostructures in model-I are suitable for water splitting at pH = 0.	Water	153-158	heme binding protein 1	Homo sapiens	63-66
32955892-0	2020	Multivalent Surface Cations Enhance Heterogeneous Freezing of Water on Muscovite Mica.	Water	62-67	MHC class I polypeptide-related sequence A	Homo sapiens	81-85
33462659-0	2021	Water-stable perovskite-on-polymer fluorescent microspheres for simultaneous monitoring of pH, urea, and urease.	Water	0-5	phenylalanine hydroxylase	Homo sapiens	91-93
32955892-2	2020	We investigate the effect of surface cations on freezing of water on muscovite mica.	Water	60-65	MHC class I polypeptide-related sequence A	Homo sapiens	79-83
32955892-9	2020	These clusters also have a large fraction of free water that can reorient to take ice-like configurations, which are promoted by the regions on mica devoid of the ions.	Water	50-55	MHC class I polypeptide-related sequence A	Homo sapiens	144-148
33100271-9	2021	Administration of MET for two weeks in drinking water (2 mg/mL) or subcutaneously (15 mg/kg/day) also resulted in NE-induced constriction of CA in vivo.	Water	48-53	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	18-21
33339539-4	2020	RESULTS: Optimal results were obtained when swabs stored in UTM were diluted 1/5 and 1/2 in RNase-free water.	Water	103-108	diluted 1/5 and 1/2	None	69-88
33050393-3	2020	EGF-Cur-NLC was prepared by a modified water-in-oil-in-water (w/o/w) double-emulsion method.	Water	39-44	epidermal growth factor like 1	Rattus norvegicus	0-3
33513284-10	2021	Therefore, our data extend to kinesin-2 the two-water ATP hydrolysis mechanism and further suggest that it is universal within the kinesin superfamily.	Water	48-53	kinesin family member 2A	Homo sapiens	30-39
33050393-3	2020	EGF-Cur-NLC was prepared by a modified water-in-oil-in-water (w/o/w) double-emulsion method.	Water	55-60	epidermal growth factor like 1	Rattus norvegicus	0-3
32798720-4	2020	QE-PEG-Ag2S has ideal water-solubility and biocompatibility and can rapidly enter cells and preferentially accumulate in cell lysosomes.	Water	22-27	angiotensin II receptor type 1	Homo sapiens	7-11
33381489-5	2020	In addition, the LC50 value is >1,000,000 mg/L water-soluble fraction; therefore, its toxicity is <10% of that of diesel in oil-based drilling fluid and, as the flash point of NSF is about 134 C, the related fire hazard is low.	Water	47-52	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	176-179
33609736-3	2021	Using a water maze competition task in which both dorsal hippocampus-dependent spatial and striatum-dependent cue navigation strategies are effective to solve the maze, we found that pharmacological inhibition of G9a/GLP activity immediately after learning disrupts long-term consolidation of previously learned spatial information in male mice, hence producing cue bias on the competition test performed 24h later.	Water	8-13	euchromatic histone methyltransferase 1	Mus musculus	217-220
33186453-5	2020	Trpm4-/--SE mice also showed less water content and cerebral edema assessed by magnetic resonance imaging, and decreased blood-brain barrier breakdown after SE.	Water	34-39	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	0-5
32806443-0	2020	Activation of percarbonate by water treatment sludge-derived biochar for the remediation of PAH-contaminated sediments.	Water	30-35	phenylalanine hydroxylase	Homo sapiens	92-95
33338789-5	2021	Inlet water from the river exhibited AhR and AR antagonistic activities.	Water	6-11	aryl hydrocarbon receptor	Homo sapiens	37-40
32645509-4	2020	The experiment investigated the physiological changes in the abundance of ESR1 in brain, pituitary and testes of immature male chickens after stress like water restriction.	Water	154-159	estrogen receptor 1	Gallus gallus	74-78
33644198-13	2021	CONCLUSION: The TEP1 (rs938886), TEP1 (rs1713449), and RECQL5 (rs820196) SNPs were associated with changes in heart rate >= 30% during intraperitoneal lavage using distilled water after gastrectomy for gastric cancer.	Water	174-179	RecQ like helicase 5	Homo sapiens	55-61
33350260-3	2020	The characteristics of moisture migration and moisture phase state in the moistening process of Paeoniae Radix Alba were that the total water content increased and existed in the form of free water, with an increased moisture mobility.	Water	136-141	afamin	Homo sapiens	111-115
33350260-3	2020	The characteristics of moisture migration and moisture phase state in the moistening process of Paeoniae Radix Alba were that the total water content increased and existed in the form of free water, with an increased moisture mobility.	Water	192-197	afamin	Homo sapiens	111-115
33350260-6	2020	The free water content and the total water content of Paeoniae Radix Alba had extremely negative correlations with hardness, surface toughness, internal toughness, Paeoniflorin and albiflorin contents(P<0.01).	Water	9-14	afamin	Homo sapiens	69-73
33350260-6	2020	The free water content and the total water content of Paeoniae Radix Alba had extremely negative correlations with hardness, surface toughness, internal toughness, Paeoniflorin and albiflorin contents(P<0.01).	Water	37-42	afamin	Homo sapiens	69-73
33291618-1	2020	The hydrogen production reaction of the proton exchange membrane (PEM) water electrolysis cell stack is the reverse reaction of the fuel cell, but the water electrolysis operation requires high pressure, and the high pressure decomposes hydrogen molecules, thus aging or causing failure in the water electrolysis cell stack.	Water	71-76	mucin 1, cell surface associated	Homo sapiens	66-69
33291618-1	2020	The hydrogen production reaction of the proton exchange membrane (PEM) water electrolysis cell stack is the reverse reaction of the fuel cell, but the water electrolysis operation requires high pressure, and the high pressure decomposes hydrogen molecules, thus aging or causing failure in the water electrolysis cell stack.	Water	151-156	mucin 1, cell surface associated	Homo sapiens	66-69
33291618-1	2020	The hydrogen production reaction of the proton exchange membrane (PEM) water electrolysis cell stack is the reverse reaction of the fuel cell, but the water electrolysis operation requires high pressure, and the high pressure decomposes hydrogen molecules, thus aging or causing failure in the water electrolysis cell stack.	Water	151-156	mucin 1, cell surface associated	Homo sapiens	66-69
33291618-4	2020	This study discusses the causes for aging or failure, and develops an internal real-time microscopic diagnosis tool for accelerated aging of the PEM water electrolysis cell stack.	Water	149-154	mucin 1, cell surface associated	Homo sapiens	145-148
33291618-5	2020	A flexible integrated (current, voltage, flow, pressure and temperature) microsensor applicable to the inside (high voltage and electrochemical environment) of the PEM water electrolysis cell stack is developed by using micro-electro-mechanical systems (MEMS) technology; it is embedded in the PEM water electrolysis cell stack for microscopic diagnosis of accelerated aging, and 100-h durability and reliability tests are performed.	Water	168-173	mucin 1, cell surface associated	Homo sapiens	164-167
33291618-5	2020	A flexible integrated (current, voltage, flow, pressure and temperature) microsensor applicable to the inside (high voltage and electrochemical environment) of the PEM water electrolysis cell stack is developed by using micro-electro-mechanical systems (MEMS) technology; it is embedded in the PEM water electrolysis cell stack for microscopic diagnosis of accelerated aging, and 100-h durability and reliability tests are performed.	Water	298-303	mucin 1, cell surface associated	Homo sapiens	164-167
33291618-5	2020	A flexible integrated (current, voltage, flow, pressure and temperature) microsensor applicable to the inside (high voltage and electrochemical environment) of the PEM water electrolysis cell stack is developed by using micro-electro-mechanical systems (MEMS) technology; it is embedded in the PEM water electrolysis cell stack for microscopic diagnosis of accelerated aging, and 100-h durability and reliability tests are performed.	Water	298-303	mucin 1, cell surface associated	Homo sapiens	294-297
33291618-6	2020	The distribution of important physical parameters inside the PEM water electrolysis cell stack can be measured instantly and accurately, so as to adjust it to the optimal operating conditions, and the local aging and failure problems are discussed.	Water	65-70	mucin 1, cell surface associated	Homo sapiens	61-64
33538599-10	2021	The improved performance of the present water models over our previous parameter sets for the TIP3P, TIP4P, and SPC/E water models (Li, P. et al J. Chem.	Water	40-45	urocortin 3	Homo sapiens	112-115
33061995-0	2020	Birzeit University Students" Perception of Bottled Water Available in the West Bank Market.	Water	51-56	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	79-83
33061995-3	2020	The objective of the study is to assess the perception of Birzeit University students" of the bottled water marketed in the West Bank and its impact on the humans and the environment.	Water	102-107	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	129-133
32993154-13	2020	Our results showed that cold water was free from microbiological hazards, but Legionella spp., was detected when the mean cold water temperature was 19.1 +- 2.2  C. This may considered close to the suboptimal value for the Legionella growth (more then 20  C).	Water	127-132	histocompatibility minor 13	Homo sapiens	89-92
32675584-0	2020	Combining Postmortem Cerebrospinal Fluid Biochemistry With Lung-to-Body Ratio to Aid the Diagnosis of Salt Water Drowning.	Water	107-112	activation induced cytidine deaminase	Homo sapiens	81-84
33129164-7	2021	Upon reducing the ambient brine salinity, this layer decomposes and the investigated surfaces of mica and - somewhat less pronounced - silica become more water wet.	Water	154-159	MHC class I polypeptide-related sequence A	Homo sapiens	97-101
32598327-1	2020	Water pollution by heavy metals due to discharge from gold mining activity has threatened the aquatic environment and human health of the community around Kao Bay.	Water	0-5	amine oxidase copper containing 1	Homo sapiens	155-158
33492922-1	2021	In this work, SnS-SnS2 heterostructured upright nanosheet frameworks are constructed on FTO substrates, which demonstrate promising photocatalytic performances for the conversion of CO2 and water to C2 (acetaldehyde) and C3 (acetone) hydrocarbons without H2 formation.	Water	190-195	sodium voltage-gated channel alpha subunit 11	Homo sapiens	18-22
32883079-7	2020	The assembly of Al4 polyanions with equivalent Ln ions afforded a series of zigzag chain structures [LnAl4(L)4(Cat)2(DMF)2(H2O)3] Hdma (Ln = Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb) (AlOC-13-Ln).	Water	123-126	solute carrier family 7 member 2	Homo sapiens	101-116
33175186-4	2020	The concentrations of E2alpha, E1, E2beta and EE2 in the bottom water were higher than the surface water due to the impact of sediment release.	Water	64-69	transcription factor 3	Homo sapiens	22-33
33175186-4	2020	The concentrations of E2alpha, E1, E2beta and EE2 in the bottom water were higher than the surface water due to the impact of sediment release.	Water	64-69	transcription factor 3	Homo sapiens	35-41
32750620-6	2020	The blending of hydrophilic PAN (0-10 wt%) in PES affects the fiber diameter, hydrophilicity, water uptake, and roughness of the ESNF membrane substrates.	Water	94-99	pescadillo ribosomal biogenesis factor 1	Homo sapiens	46-49
33492922-4	2021	The experimental results and DFT calculations suggest that the SnS-SnS2 heterojunction nanosheet framework photocatalyst experiences Z-scheme charge transfer dynamic to allow the water oxidation and CO2 reduction reactions occurring on the surfaces of SnS2 and SnS, respectively.	Water	179-184	sodium voltage-gated channel alpha subunit 11	Homo sapiens	67-71
32961653-4	2020	Subsequent reaction of HL1 and HL2 with CuCl2 2H2O in 1:1 molar ratio in methanol produced the complexes [CuII(HL1)Cl2] H2O (1 H2O) and [CuII(HL2)Cl2] (2).	Water	47-50	intelectin 2	Homo sapiens	31-34
32961653-4	2020	Subsequent reaction of HL1 and HL2 with CuCl2 2H2O in 1:1 molar ratio in methanol produced the complexes [CuII(HL1)Cl2] H2O (1 H2O) and [CuII(HL2)Cl2] (2).	Water	47-50	intelectin 2	Homo sapiens	142-145
32961653-4	2020	Subsequent reaction of HL1 and HL2 with CuCl2 2H2O in 1:1 molar ratio in methanol produced the complexes [CuII(HL1)Cl2] H2O (1 H2O) and [CuII(HL2)Cl2] (2).	Water	120-123	intelectin 2	Homo sapiens	31-34
33492922-4	2021	The experimental results and DFT calculations suggest that the SnS-SnS2 heterojunction nanosheet framework photocatalyst experiences Z-scheme charge transfer dynamic to allow the water oxidation and CO2 reduction reactions occurring on the surfaces of SnS2 and SnS, respectively.	Water	179-184	sodium voltage-gated channel alpha subunit 11	Homo sapiens	252-256
33495344-8	2021	The discovery of NST1 as a key substrate for phosphorylation by SnRK2 suggests that the ABA-mediated core-signaling cascade provided land plants with a hormone-modulated, competitive desiccation-tolerance strategy allowing them to differentiate water-conducting and supporting tissues built of cells with thicker cell walls.	Water	245-250	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	17-21
32736212-0	2020	Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of human soluble epoxide hydrolase inhibitors.	Water	81-86	epoxide hydrolase 2	Homo sapiens	107-132
32519438-3	2020	The results were linear in water over the concentration range 50-600 ng ml-1 with a correlation coefficient r = 0.9999 and intercept 1.1555.	Water	27-32	interleukin 17F	Homo sapiens	72-76
33595653-2	2021	Here, we drastically enhance water solubility of FY26 through the replacement of the PF6- counter-anion with chloride using a novel synthesis method.	Water	29-34	sperm associated antigen 17	Homo sapiens	85-88
33239623-3	2020	The temperature responsive luminescence behavior of PSS-[Tb2(TCAn)2] within 293-333 K range in water is modulated by reversible changes derived from the back energy transfer from metal to ligand (M*   T1) correlating with the energy gap between the triplet levels of ligands and resonant 5D4 level of Tb3+ ion.	Water	95-100	receptor accessory protein 5	Homo sapiens	57-60
33345501-7	2020	Soil water storage in 0-300 cm profile of PRF and PMS increased by 59.7 mm and 41.8 mm from sowing to seedling stage.	Water	5-10	proline rich protein BstNI subfamily 1	Homo sapiens	50-53
33345501-8	2020	Water consumption of PRF and PMS increased by 46.1 mm and 39.8 mm from seedling to filling stage.	Water	0-5	proline rich protein BstNI subfamily 1	Homo sapiens	29-32
32789767-4	2021	We find that SHP can fragment river systems in ways that reduce irrigation water availability, provoke changes to agricultural practices, and negatively impact river health.	Water	75-80	nuclear receptor subfamily 0 group B member 2	Homo sapiens	13-16
33124283-5	2020	The TN/TP ratios in water-passing lakes, deep reservoirs and eutrophic lakes were 20.41+-9.25, 40.97+-33.37, and 14.38+-7.40 during spring, and were 22.62+-6.48, 96.38+-45.91, and 10.91+-4.44 during summer, respectively.	Water	20-25	C-type lectin domain family 3 member B	Homo sapiens	4-9
33124283-6	2020	The TN/TP of the water-passing lakes and deep reservoirs increased significantly in summer, while that of the eutrophic lakes decreased significantly, which indicates that TN/TP changes and lake nutritional status are closely related.	Water	17-22	C-type lectin domain family 3 member B	Homo sapiens	4-9
33124283-6	2020	The TN/TP of the water-passing lakes and deep reservoirs increased significantly in summer, while that of the eutrophic lakes decreased significantly, which indicates that TN/TP changes and lake nutritional status are closely related.	Water	17-22	C-type lectin domain family 3 member B	Homo sapiens	172-177
33007552-3	2020	An earlier somewhat water soluble sEH inhibitor taken to the clinic for blood pressure control had mediocre potency (both affinity and kinetics) and a short in vivo half-life.	Water	20-25	epoxide hydrolase 2	Homo sapiens	34-37
33274009-9	2020	NDP-MSH treatment significantly attenuated the neurological deficits and brain water content 24 hours after ICH, which was accompanied by the inhibition of oxidative stress and neuronal apoptosis.	Water	79-84	Norrie disease (pseudoglioma) (human)	Mus musculus	0-3
32920270-5	2021	SlPG2, SlEXP1, and SlCEL2 mRNAs accumulation was reduced in OG-elicited tomato fruit compared to water-treated fruit with subsequent retardation of the fruit softening during ripening.	Water	97-102	endo-1,4-beta-glucanase precursor	Solanum lycopersicum	19-25
32640387-5	2020	While individual storm events released high THM precursor concentrations over short periods, dry season agricultural irrigation as well as urban landscapes have the potential to release water high in THM precursors for several months.	Water	186-191	THM	Homo sapiens	200-203
32640387-7	2020	This finding has considerable implications for water managers, who may therefore consider THM precursor management strategies that target even sources located far upstream.	Water	47-52	THM	Homo sapiens	90-93
33014978-9	2020	In addition, practice of HIP was significantly associated with the aforementioned factors, as well as with water source and knowledge of HIP.	Water	107-112	hedgehog interacting protein	Homo sapiens	25-28
33417258-1	2021	Aldosterone, the main mineralocorticoid hormone in humans, plays a pivotal role in the control of water and salt reabsorption via activation of the mineralocorticoid receptor (MR).	Water	98-103	nuclear receptor subfamily 3 group C member 2	Homo sapiens	148-174
31822117-3	2020	GPx1 and GPx4 dampen phosphorylation cascades predominantly via prevention of inactivation of phosphatases by H2O2 or lipid hydroperoxides.	Water	110-114	glutathione peroxidase GPX1	Saccharomyces cerevisiae S288C	0-4
33124233-4	2020	The landscape characteristics for the 300 m and 100 m buffer zones appeared to have slightly greater effects on the water quality index TN and TP, respectively.	Water	116-121	C-type lectin domain family 3 member B	Homo sapiens	136-138
33417258-1	2021	Aldosterone, the main mineralocorticoid hormone in humans, plays a pivotal role in the control of water and salt reabsorption via activation of the mineralocorticoid receptor (MR).	Water	98-103	nuclear receptor subfamily 3 group C member 2	Homo sapiens	176-178
33109505-9	2021	RESULTS: Based on multivariable models, each 8 oz of additional daily juice and water/SFB decreased expected DFSAR by 53% (95% confidence interval [CI]: 17%-73%) and 29% (95% CI: 7%-46%), respectively, and 8 additional oz SSBs increased expected DFSAR by 42% (95% CI: 5%-92%), after adjustment for other beverage intakes, toothbrushing, total fluoride intake excluding SSB fluoride (non-SSB total fluoride), sex, and baseline socioeconomic status.	Water	80-85	small RNA binding exonuclease protection factor La	Homo sapiens	222-225
33171990-2	2020	EAU was induced in C57/BL6 mice by injection of human interphotoreceptor retinoid-binding protein (IRBP) peptides.	Water	0-3	retinol binding protein 3	Homo sapiens	54-97
33171990-2	2020	EAU was induced in C57/BL6 mice by injection of human interphotoreceptor retinoid-binding protein (IRBP) peptides.	Water	0-3	retinol binding protein 3	Homo sapiens	99-103
32629019-0	2020	Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1.	Water	47-52	carboxylesterase 1	Homo sapiens	135-153
32629019-2	2020	In this study, design, synthesis and evaluation of water-soluble phenytoin prodrugs were performed with consideration of the substrate recognition ability of hCES1.	Water	51-56	carboxylesterase 1	Homo sapiens	158-163
31975412-5	2020	The results of this study showed that lncRNA H19 expression was significantly upregulated in mouse hearts subjected to myocardial IP, in rat H9C2 cells exposed to H2 O2 preconditioning (H2 O2 -PC), and in neonatal rat cardiomyocytes subjected to hypoxia preconditioning.	Water	163-168	H19, imprinted maternally expressed transcript	Mus musculus	45-48
33109505-9	2021	RESULTS: Based on multivariable models, each 8 oz of additional daily juice and water/SFB decreased expected DFSAR by 53% (95% confidence interval [CI]: 17%-73%) and 29% (95% CI: 7%-46%), respectively, and 8 additional oz SSBs increased expected DFSAR by 42% (95% CI: 5%-92%), after adjustment for other beverage intakes, toothbrushing, total fluoride intake excluding SSB fluoride (non-SSB total fluoride), sex, and baseline socioeconomic status.	Water	80-85	small RNA binding exonuclease protection factor La	Homo sapiens	369-372
31975412-5	2020	The results of this study showed that lncRNA H19 expression was significantly upregulated in mouse hearts subjected to myocardial IP, in rat H9C2 cells exposed to H2 O2 preconditioning (H2 O2 -PC), and in neonatal rat cardiomyocytes subjected to hypoxia preconditioning.	Water	186-191	H19, imprinted maternally expressed transcript	Mus musculus	45-48
31975412-6	2020	H19 knockdown abrogated the H2 O2 -PC-mediated protection in cardiomyocytes evidenced by the decreased cell viability and increased caspase-3 activity.	Water	28-33	caspase 3	Rattus norvegicus	132-141
33526798-2	2021	It is well recognised that the mineralocorticoid receptor (MR) plays an important role in blood pressure regulation via its effect on salt and water retention in renal tubules, with hypertension being a key feature in primary aldosteronism patients with excess adrenal production of aldosterone, the primary ligand for MRs in the epithelial tissues.	Water	143-148	nuclear receptor subfamily 3 group C member 2	Homo sapiens	31-57
31975412-8	2020	In addition, H19 overexpression increased the expression of nucleolin, whereas H19 ablation abrogated H2 O2 -PC-induced upregulation of nucleolin in cardiomyocytes.	Water	102-107	nucleolin	Rattus norvegicus	136-145
33139847-9	2021	In the multivariate analysis, the predictive factors for VUR were: (1) maximum detrusor pressure at first visit >= 75 cm of water (HRadj: 2.4 [95% CI: 1.4-4.1]); (2) indwelling urethral catheterization (IUC) (HRadj: 11.1 [95% CI: 3.9-31.7]) and clean intermittent catheterization (CIC) (HRadj: 6.5 [95% CI: 2.2-18.7]); (3) age >= 60 years at onset of SCI (HRadj: 1.7 [95% CI: 1.1-2.8]); and, (4) absence of antimuscarinic medication (HRadj: 3.8 [95% CI: 2.4-6.1]).	Water	124-129	VUR	Homo sapiens	57-60
33526798-2	2021	It is well recognised that the mineralocorticoid receptor (MR) plays an important role in blood pressure regulation via its effect on salt and water retention in renal tubules, with hypertension being a key feature in primary aldosteronism patients with excess adrenal production of aldosterone, the primary ligand for MRs in the epithelial tissues.	Water	143-148	nuclear receptor subfamily 3 group C member 2	Homo sapiens	59-61
32434129-3	2020	It is well-known that uric acid is an organic compound and the water-soluble final product of purine catabolism, which is catalysed by xanthine oxidoreductase and excreted by kidneys.	Water	63-68	xanthine dehydrogenase	Homo sapiens	135-158
33491619-13	2021	Most caregivers (64%-99%) would employ recommended first aid practices to manage common injuries, such as running cool water over a burn injury or tying a bleeding laceration with a piece of cloth.	Water	119-124	activation induced cytidine deaminase	Homo sapiens	57-60
32736673-6	2020	The findings revealed that inhibition of TREM-1 by administering LP17 improved cerebral damage and decreased ischemic areas and brain water contents.	Water	134-139	triggering receptor expressed on myeloid cells 1	Rattus norvegicus	41-47
32836698-7	2020	There are also massive volumes of fresh water trapped in hydrates that could aid in fighting droughts and desertification.	Water	40-45	activation induced cytidine deaminase	Homo sapiens	77-80
33517493-4	2021	In the present study, we have highlighted the role of water molecules in hydrogen-bond optimization, in determining pKa values and protonation states of titratable residues in JH2 domain of JAK2 apo protein.	Water	54-59	Janus kinase 2	Homo sapiens	190-194
32853485-9	2020	The ROCK2, PMVK, ADCY2, MAP2K6, BMP10 and GFPT1 genes are main candidates for reproductive traits in water dairy buffaloes and, these results may have future applications in animal breeding programs or in gene expression studies of the species.	Water	101-106	dual specificity mitogen-activated protein kinase kinase 6	Bubalus bubalis	24-30
32702990-2	2020	Inward-rectifier K+ (Kir) channels are often activated by anionic lipids endemic to their native membranes and require accessible water along their K+ conductance pathway.	Water	130-135	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	21-24
33469018-5	2021	We report that, at this developmental stage, the ChP showed increased ATP production and increased expression of ATP-dependent K+ transporters, particularly the Na+, K+, Cl-, and water cotransporter NKCC1.	Water	179-184	solute carrier family 12, member 2	Mus musculus	199-204
32619376-1	2020	Objectives: The aim of this study is to evaluate the association between the single nucleotide polymorphism (SNP) rs4284505 within the gene that codifies microRNA17 (miRNA17) and dental fluorosis (DF) in a group of children.Methods: Children living in a city with fluoridation of public water supplies were included.	Water	287-292	microRNA 17	Homo sapiens	154-164
32619376-1	2020	Objectives: The aim of this study is to evaluate the association between the single nucleotide polymorphism (SNP) rs4284505 within the gene that codifies microRNA17 (miRNA17) and dental fluorosis (DF) in a group of children.Methods: Children living in a city with fluoridation of public water supplies were included.	Water	287-292	microRNA 17	Homo sapiens	166-173
33304224-1	2020	Mixed ionic electronic conducting ceramics Nd6-y WO12-delta (delta is the oxygen deficiency) provide excellent stability in harsh environments containing strongly reactive gases such as CO2, CO, H2, H2O or H2S.	Water	199-202	mitochondrially encoded NADH dehydrogenase 6	Homo sapiens	43-46
32985179-5	2020	Vibrational sum-frequency generation spectroscopy reveals that H-mica induces substantially less orientation ordering than Na-/K-mica within the contact water layer at the interface.	Water	153-158	MHC class I polypeptide-related sequence A	Homo sapiens	65-69
32985179-6	2020	Molecular dynamics simulations suggest that the HIN efficiency of mica depends on the positional arrangement and orientation of the interfacial water.	Water	144-149	MHC class I polypeptide-related sequence A	Homo sapiens	66-70
32985179-7	2020	The formation of the hexagonal ice Ih basal-type structure in the first water layer atop the mica surface facilitates HIN, which is determined by the size of the protruding ions atop the mica surface and by the surface adsorption energy.	Water	72-77	MHC class I polypeptide-related sequence A	Homo sapiens	93-97
32985179-7	2020	The formation of the hexagonal ice Ih basal-type structure in the first water layer atop the mica surface facilitates HIN, which is determined by the size of the protruding ions atop the mica surface and by the surface adsorption energy.	Water	72-77	MHC class I polypeptide-related sequence A	Homo sapiens	187-191
32626923-6	2020	Cell Counting Kit-8 assays, Hoechst staining, calcein-AM/PI staining, immunostaining, water maze tests and rotarod tests demonstrated that BDNF-AS silencing protected against hypoxia-induced primary hippocampal neuron injury in vitro and HI-induced brain injury in vivo.	Water	86-91	BDNF antisense RNA	Homo sapiens	139-146
33280699-3	2021	Benefiting from the appreciable loading of Eu-pbmc nanoparticles and high water permeation flux, PEM possesses effective detection for MnO4- with a limit of detection (LOD) of 17 nM.	Water	74-79	mucin 1, cell surface associated	Homo sapiens	97-100
32458405-5	2020	Here, we report that repeated exposures of neonatal mice (P7-9 days old) to anesthesia with sevoflurane (3 h/day for 3 days) led to cognitive impairment that was detectable at the age of 18-19 months, as assessed by using novel object recognition, Morris water maze, and fear conditioning tests.	Water	255-260	leucine rich repeat containing 49	Mus musculus	58-62
32985179-8	2020	The orienta-tional distribution is optimal for HIN when 25% of the water molecules in the first water layer atop the mica surface have one OH group pointing up and 25% have one OH group pointing down, which, in turn, is determined by the surface charge distribution.	Water	67-72	MHC class I polypeptide-related sequence A	Homo sapiens	117-121
32985179-8	2020	The orienta-tional distribution is optimal for HIN when 25% of the water molecules in the first water layer atop the mica surface have one OH group pointing up and 25% have one OH group pointing down, which, in turn, is determined by the surface charge distribution.	Water	96-101	MHC class I polypeptide-related sequence A	Homo sapiens	117-121
33466953-2	2021	This study assessed the association between the presence of household hand-washing facilities with water and soap and diarrhea episodes among children U5 in Lao PDR.	Water	99-104	interleukin 4 induced 1	Homo sapiens	157-160
32544584-1	2020	In this paper, a novel acidic polysaccharide (CPS-1) was successively prepared from Gynostemma pentaphyllum using hot water isolation method to explore its antitumor and antioxidant activities.	Water	118-123	carbamoyl-phosphate synthase 1	Homo sapiens	46-51
33402063-7	2022	The results show that the effective thermal conductivity and the heat capacity decrease with the reduction of the water content from 2.60 W m-1 K-1 and 2.52 J g-1 K-1 for a wet sludge to 1.71 W m-1 K-1 and 0.78 J g-1 K-1 for a dry sludge respectively.	Water	114-119	keratin 1	Homo sapiens	144-153
33173592-4	2020	Taking into account the mechanisms of hydrophobic interaction, hydration shell, surface tension, and the shielding effect of water molecules, this study reveals a hydrophobic-interaction-based mechanism by means of which SARS-CoV-2 S and ACE2 bind together in an aqueous environment.	Water	125-130	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	221-222
33173592-4	2020	Taking into account the mechanisms of hydrophobic interaction, hydration shell, surface tension, and the shielding effect of water molecules, this study reveals a hydrophobic-interaction-based mechanism by means of which SARS-CoV-2 S and ACE2 bind together in an aqueous environment.	Water	125-130	angiotensin converting enzyme 2	Homo sapiens	238-242
33402063-7	2022	The results show that the effective thermal conductivity and the heat capacity decrease with the reduction of the water content from 2.60 W m-1 K-1 and 2.52 J g-1 K-1 for a wet sludge to 1.71 W m-1 K-1 and 0.78 J g-1 K-1 for a dry sludge respectively.	Water	114-119	keratin 1	Homo sapiens	198-207
33146549-0	2021	Water intake accelerates ATP release from myofibroblast cells in rats: ATP-mediated podoplanin-dependent control for physiological function and immunity.	Water	0-5	podoplanin	Rattus norvegicus	84-94
33090513-0	2020	Water-soluble fraction of particulate matter <2.5 mum promoted lung epithelia cells apoptosis by regulating the expression of caveolin-1 and Kruppel-like factor 5.	Water	0-5	Kruppel like factor 5	Homo sapiens	141-162
33017321-3	2020	Li4[Ru2OCl10] 10H2O crystallizes into a low-symmetry triclinic structure (P1) due to the much smaller Li+ cation compared to K+ cation in the tetragonal complex K4[Ru2OCl10] H2O.	Water	16-19	lipase family member N	Homo sapiens	0-3
33146549-7	2021	Water intake accelerated immunohistochemical expressions of podoplanin and IL-22 in the interepithelial layers and lamina propria of the jejunum.	Water	0-5	podoplanin	Rattus norvegicus	60-70
33146549-10	2021	In conclusion, water intake-mediated shear stress stimulation-dependent ATP release from myofibroblast cells maintains higher tissue colloid osmotic pressure in the jejunal microcirculation through podoplanin upregulation in the interepithelial layers.	Water	15-20	podoplanin	Rattus norvegicus	198-208
33297218-7	2021	The use of biochar results in a decrease (i.e. up to 20%) of the PAH degradation during bioaugmentation and phytoremediation of sediments, as a consequence of the reduction of PAH bioavailability and an increase of water and nutrient retention.	Water	215-220	phenylalanine hydroxylase	Homo sapiens	65-68
31880198-8	2020	In conclusion, our research reveals a novel molecular mechanism that oxidative modification at Cys292 and Cys361 sites regulates ATG4B function, which modulates autophagy.Abbreviations: Air-ox: air-oxidation; ATG4B: autophagy related 4B cysteine peptidase; BCNU: 1,3-bis(2-chloroethyl)-1-nitrosourea; CBB: Coomassie Brilliant Blue; CM: complete medium; CQ: chloroquine; DTT: dithiothreitol; GSH: reduced glutathione; GSNO: S-nitrosoglutathione; GSSG: oxidized glutathione; HMW: high molecular weight; H2O2: hydrogen peroxide; NAC: N-acetyl-L-cysteine; NEM: N-ethylmaleimide; PE: phosphatidylethanolamine; PTM: post-translational modification; ROS, reactive oxygen species; WT: wild type.	Water	501-505	autophagy related 4B cysteine peptidase	Homo sapiens	129-134
31880198-8	2020	In conclusion, our research reveals a novel molecular mechanism that oxidative modification at Cys292 and Cys361 sites regulates ATG4B function, which modulates autophagy.Abbreviations: Air-ox: air-oxidation; ATG4B: autophagy related 4B cysteine peptidase; BCNU: 1,3-bis(2-chloroethyl)-1-nitrosourea; CBB: Coomassie Brilliant Blue; CM: complete medium; CQ: chloroquine; DTT: dithiothreitol; GSH: reduced glutathione; GSNO: S-nitrosoglutathione; GSSG: oxidized glutathione; HMW: high molecular weight; H2O2: hydrogen peroxide; NAC: N-acetyl-L-cysteine; NEM: N-ethylmaleimide; PE: phosphatidylethanolamine; PTM: post-translational modification; ROS, reactive oxygen species; WT: wild type.	Water	501-505	autophagy related 4B cysteine peptidase	Homo sapiens	209-214
33009206-2	2021	Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water.	Water	209-214	superoxide dismutase 2	Homo sapiens	70-100
33009206-2	2021	Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water.	Water	209-214	superoxide dismutase 2	Homo sapiens	102-106
32439913-1	2020	The Hippocratic text On Airs, Waters, Places advises physicians to attend to all aspects of the environment-the seasons, the wind direction, and the soil and water quality, i.e., the ecosystem-when addressing people"s health.	Water	158-163	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	24-28
33186174-2	2021	The fat concentration was measured on fat (water)-based images.	Water	43-48	FAT atypical cadherin 1	Homo sapiens	4-7
33092334-4	2021	Peak2 is the maximum speed in the first downward kick after the arm entry into the water.	Water	83-88	PEAK1 related, kinase-activating pseudokinase 1	Homo sapiens	0-5
33077138-2	2020	AQP1, AQP3 and AQP5 are isoforms of aquaporin known to aid in transepithelial water movement.	Water	78-83	activation induced cytidine deaminase	Homo sapiens	55-58
33376867-4	2020	The peroxone process had 75-88.5% chemical oxygen demand (COD) reduction efficiency at pH 5-11 in 3 h. Adsorption by activated char further reduced the COD to 85.4-92.7% for pH 5-11 in 2.5 h. All other water quality parameters were significantly decreased (>73% removal) during ozonation.	Water	202-207	phenylalanine hydroxylase	Homo sapiens	174-176
33169770-1	2020	Water-dispersed gold nanoparticles decorated with an amphiphilic cyclotetrasiloxane scaffold hold promise for the catalytic transformation of diorganosilanes to tetraorganodisiloxane-1,3-diols, (RR1SiOH)2O [R = Me or Ph R1 = Ph, cyclo-Hex] via en route formation of a Pickering emulsion.	Water	0-5	hematopoietically expressed homeobox	Homo sapiens	235-238
33196716-0	2020	Water-induced mica/ionic liquid interfacial nanostructure switches revealed by AFM.	Water	0-5	MHC class I polypeptide-related sequence A	Homo sapiens	14-18
33196716-1	2020	Glovebox-AFM-based force curve measurements have been employed to investigate the effect of controlled small amounts of water on the interfacial structure of mica/a pyrrolidinium-based ionic liquid.	Water	120-125	MHC class I polypeptide-related sequence A	Homo sapiens	158-162
33231595-6	2020	Three different product complexes, ketene HO2, ketene H2O HO2 and ketene (H2O)2 HO2, are formed from the reaction.	Water	54-57	heme oxygenase 2	Homo sapiens	58-61
33231595-6	2020	Three different product complexes, ketene HO2, ketene H2O HO2 and ketene (H2O)2 HO2, are formed from the reaction.	Water	54-57	heme oxygenase 2	Homo sapiens	58-61
33273526-2	2020	A variant in PRCD previously identified in Portuguese Water Dogs (PWDs) underlies prcd (progressive rod-cone degeneration), an autosomal recessive progressive retinal atrophy (PRA) with a late onset at 3-6 years of age or older.	Water	54-59	photoreceptor disc component	Canis lupus familiaris	13-17
33273526-2	2020	A variant in PRCD previously identified in Portuguese Water Dogs (PWDs) underlies prcd (progressive rod-cone degeneration), an autosomal recessive progressive retinal atrophy (PRA) with a late onset at 3-6 years of age or older.	Water	54-59	photoreceptor disc component	Canis lupus familiaris	82-86
33354281-8	2020	Fluid restriction and water hydration mildly increased urine osmolality and induced a 15% fall in CrCl while increased the markers of tubular damage by NAG and KIM-1.	Water	22-27	sodium voltage-gated channel alpha subunit 7	Rattus norvegicus	152-155
32822237-6	2020	We discovered that VEA caused dose-dependent increases in lung water and BAL protein compared with control and JUUL-exposed mice in association with increased BAL neutrophils, oil-laden macrophages, multinucleated giant cells, and inflammatory cytokines.	Water	63-68	CD69 antigen	Mus musculus	19-22
31088264-0	2020	Bromate removal from water by acid activated and surfactant enriched Red Mud - the case of cooling water.	Water	21-26	adaptor related protein complex 5 subunit mu 1	Homo sapiens	73-76
32529957-1	2020	Bordering the wealthy town of Apex, North Carolina, is a majority African-American neighborhood, Irongate Drive, without town water service, relying on private wells.	Water	126-131	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	30-34
31088264-1	2020	Red Mud is a hazardous by-product of the Bayer process, used to produce alumina from bauxite, with ability to adsorb anions from water.	Water	129-134	adaptor related protein complex 5 subunit mu 1	Homo sapiens	4-7
32950517-6	2020	The cake layer with a higher thickness was observed to be rapidly formed on the membrane surface at the presence of SA in water.	Water	122-127	acyl-CoA synthetase medium chain family member 3	Homo sapiens	116-118
32849690-8	2020	JAC1 has positive effect on water use efficiency (WUE) by reducing stomatal aperture and water vapor conductance.	Water	28-33	J-domain protein required for chloroplast accumulation response 1	Arabidopsis thaliana	0-4
32849690-8	2020	JAC1 has positive effect on water use efficiency (WUE) by reducing stomatal aperture and water vapor conductance.	Water	89-94	J-domain protein required for chloroplast accumulation response 1	Arabidopsis thaliana	0-4
33170663-5	2020	The measured Hamaker constant for silver-water-mica was consistent with Lifshitz theory.	Water	41-46	MHC class I polypeptide-related sequence A	Homo sapiens	47-51
32731584-0	2020	Characterisation of the Interaction among Oil-In-Water Nanocapsules and Mucin.	Water	49-54	LOC100508689	Homo sapiens	72-77
32711646-1	2020	Herein, we report the synthesis of SnO, Cu2O and SnO-Cu2O mixed oxide thin films on fluorinedoped tin oxide (FTO) substrate by Aerosol-Assisted Chemical Vapour Deposition (AACVD) process using [Cu (dmae)2(H2O)] and [Sn (dmae) (OAc)]2 as molecular precursors for SnO and Cu2O, respectively at 400  C. The X-ray diffraction (XRD) pattern can be ascribed to the tetragonal phase of SnO crystals with space group P4 and cubic phase of Cu2O crystals with space group Pn- 3m/nmm, respectively.	Water	205-208	strawberry notch homolog 1	Homo sapiens	35-38
32239715-0	2020	Surface charges at the CaF2 water interface allow very fast intermolecular vibrational energy transfer.	Water	28-33	CCR4-NOT transcription complex subunit 8	Homo sapiens	23-27
32711646-1	2020	Herein, we report the synthesis of SnO, Cu2O and SnO-Cu2O mixed oxide thin films on fluorinedoped tin oxide (FTO) substrate by Aerosol-Assisted Chemical Vapour Deposition (AACVD) process using [Cu (dmae)2(H2O)] and [Sn (dmae) (OAc)]2 as molecular precursors for SnO and Cu2O, respectively at 400  C. The X-ray diffraction (XRD) pattern can be ascribed to the tetragonal phase of SnO crystals with space group P4 and cubic phase of Cu2O crystals with space group Pn- 3m/nmm, respectively.	Water	205-208	strawberry notch homolog 1	Homo sapiens	49-52
32711646-1	2020	Herein, we report the synthesis of SnO, Cu2O and SnO-Cu2O mixed oxide thin films on fluorinedoped tin oxide (FTO) substrate by Aerosol-Assisted Chemical Vapour Deposition (AACVD) process using [Cu (dmae)2(H2O)] and [Sn (dmae) (OAc)]2 as molecular precursors for SnO and Cu2O, respectively at 400  C. The X-ray diffraction (XRD) pattern can be ascribed to the tetragonal phase of SnO crystals with space group P4 and cubic phase of Cu2O crystals with space group Pn- 3m/nmm, respectively.	Water	205-208	strawberry notch homolog 1	Homo sapiens	49-52
32711646-1	2020	Herein, we report the synthesis of SnO, Cu2O and SnO-Cu2O mixed oxide thin films on fluorinedoped tin oxide (FTO) substrate by Aerosol-Assisted Chemical Vapour Deposition (AACVD) process using [Cu (dmae)2(H2O)] and [Sn (dmae) (OAc)]2 as molecular precursors for SnO and Cu2O, respectively at 400  C. The X-ray diffraction (XRD) pattern can be ascribed to the tetragonal phase of SnO crystals with space group P4 and cubic phase of Cu2O crystals with space group Pn- 3m/nmm, respectively.	Water	205-208	strawberry notch homolog 1	Homo sapiens	49-52
32627788-3	2020	In an attempt to understand the role played by intermolecular interactions in the election of CGAT as the alphabet of life, we present here a thorough experimental and computational study on the interaction of theobromine with water.	Water	227-232	solute carrier family 18 member A1	Homo sapiens	94-98
32686492-1	2022	A novel water-soluble polysaccharide, named ICP-1, was isolated and purified by Sephadex G-200 after extracting the crude polysaccharide (ICP) from Imperial Chrysanthemum.	Water	8-13	ATPase phospholipid transporting 8B1	Homo sapiens	44-49
33268890-8	2020	In addition, mechanical perturbation of the water at frequencies similar to the movements of the zebrafish tail was sufficient to rescue the levels of pth2 in previously isolated fish.	Water	44-49	parathyroid hormone 2	Danio rerio	151-155
32650545-0	2020	Potential Metabolite Nymphayol Isolated from Water Lily (Nymphaea stellata) Flower Inhibits MCF-7 Human Breast Cancer Cell Growth via Upregulation of Cdkn2a, pRb2, p53 and Downregulation of PCNA mRNA Expressions.	Water	45-50	proline rich protein BstNI subfamily 2	Homo sapiens	158-162
32936726-6	2020	It warrants mentioning that we have identified that HSFA6a and HSFA6b also involved in other major ABA responses, including ABA-inhibited seed germination, stomatal movement, and water loss.	Water	179-184	heat shock transcription factor A6B	Arabidopsis thaliana	63-69
32549616-0	2020	Mungbean seed coat water extract inhibits inflammation in LPS-induced acute liver injury mice and LPS-stimulated RAW 246.7 macrophages via the inhibition of TAK1/IkappaBalpha/NF-kappaB.	Water	19-24	mitogen-activated protein kinase kinase kinase 7	Mus musculus	157-161
33203675-7	2020	Thus, a water-mediated clamp and DNA interface enables the PCNA clamp to "waterskate" along the duplex with minimum drag.	Water	8-13	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	59-63
32325220-7	2020	However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine).	Water	308-313	dipeptidase 1	Homo sapiens	29-34
33292360-0	2020	Water treadmill training attenuates blood-spinal cord barrier disruption in rats by promoting angiogenesis and inhibiting matrix metalloproteinase-2/9 expression following spinal cord injury.	Water	0-5	matrix metallopeptidase 2	Rattus norvegicus	122-150
32744432-3	2020	Here, the overexpression of Lateral Organ Boundaries Domain 15 (LBD15) showed abscisic acid (ABA) hypersensitivity and water-deficit stress tolerance, whereas its loss-of-function mutant lbd15 presented decreased sensitivity to ABA and increased sensitivity to water-deficit stress.	Water	119-124	LOB domain-containing protein 15	Arabidopsis thaliana	64-69
32695023-0	2020	Aquaporin-7: A Dynamic Aquaglyceroporin With Greater Water and Glycerol Permeability Than Its Bacterial Homolog GlpF.	Water	53-58	aquaporin 7	Homo sapiens	0-11
33235538-7	2021	Plasma-activated water after room-temperature storage of 30 days remained capable of significantly reducing the RBD binding with hACE2.	Water	17-22	angiotensin converting enzyme 2	Homo sapiens	129-134
32695023-1	2020	Xenopus oocytes expressing human aquaporin-7 (AQP7) exhibit greater osmotic water permeability and 3H-glycerol uptake vs. those expressing the bacterial glycerol facilitator GlpF.	Water	76-81	aquaporin 7	Homo sapiens	33-44
32695023-1	2020	Xenopus oocytes expressing human aquaporin-7 (AQP7) exhibit greater osmotic water permeability and 3H-glycerol uptake vs. those expressing the bacterial glycerol facilitator GlpF.	Water	76-81	aquaporin 7	Homo sapiens	46-50
33350260-0	2020	[Correlation between water state and texture during moistening of Paeoniae Radix Alba by LF-NMR/MRI].	Water	21-26	afamin	Homo sapiens	81-85
33184370-1	2020	The renin-angiotensin system is known to regulate blood pressure as well as water- and electrolyte balance.	Water	76-81	renin	Rattus norvegicus	4-9
33013321-6	2020	To this end, the overexpression of GSK-3beta remained OFF during embryonic and postnatal development by administration of doxycycline in drinking water for 6 months, while it was turned ON in adult animals by removal of the treatment for 6 months.	Water	146-151	glycogen synthase kinase 3 alpha	Mus musculus	35-44
32470284-3	2020	The hydrogen bonds network which are constructed by the uncoordinated anionic tetrazolium, and the coordinated and free water molecules endowed this Eu-MOF with the highest proton conductivity of 4.45x10-2 S/cm at 373 K and 93% RH.	Water	120-125	lysine acetyltransferase 8	Homo sapiens	152-155
32780796-9	2020	This suggests that CCTalpha not only displays structural but also functional adaptations to deep water conditions.	Water	97-102	t-complex 1	Homo sapiens	19-27
32525150-0	2020	Ion and water transport reasonably involves rotation and pseudorotation: measurement and modeling the temperature dependence of small-angle neutron scattering from aqueous SrI2.	Water	8-13	chromosome 17 open reading frame 75	Homo sapiens	172-176
32657342-1	2020	In this study, we propose a methodology for temperature determination of the temperature and pressure correction factor, PTP, by analyzing the temperature distribution of the modeled ionization chamber taking into account the thermal effect of a water phantom on neighboring materials in the process.	Water	246-251	protein tyrosine phosphatase receptor type U	Homo sapiens	121-124
32976262-0	2020	Fat-Water Swaps in Iterative Decomposition of Water and Fat With Echo Asymmetry and Least-Squares Estimation Magnetic Resonance Imaging for Postinstrumentation Spine.	Water	4-9	FAT atypical cadherin 1	Homo sapiens	0-3
32579978-8	2020	Mice with RIP140 overexpression in the SGZ exhibited deficits in cognitive function and spatial learning and memory, measured in the Morris water maze, object-place recognition test, and novel object recognition test.	Water	140-145	nuclear receptor interacting protein 1	Mus musculus	10-16
32579978-9	2020	However, overexpression of RIP140 in SVZ only impaired performance in the Morris water maze and novel object recognition test but not in the object-place recognition test.	Water	81-86	nuclear receptor interacting protein 1	Mus musculus	27-33
32556285-9	2020	Furthermore, supplementation of the drinking water with butyrate, the most immunologically active SCFA, successfully achieved attenuation of the FVIII immune response.	Water	45-50	coagulation factor VIII	Mus musculus	145-150
32576884-8	2020	For example, in the case of the electrolysis of acidic water at an overpotential of 0.15 V, Type I shows a Tafel slope of 29 mV dec-1 and a current density of 27.5 mA cm-2.	Water	55-60	deleted in esophageal cancer 1	Homo sapiens	128-133
32976262-0	2020	Fat-Water Swaps in Iterative Decomposition of Water and Fat With Echo Asymmetry and Least-Squares Estimation Magnetic Resonance Imaging for Postinstrumentation Spine.	Water	4-9	FAT atypical cadherin 1	Homo sapiens	56-59
32976262-0	2020	Fat-Water Swaps in Iterative Decomposition of Water and Fat With Echo Asymmetry and Least-Squares Estimation Magnetic Resonance Imaging for Postinstrumentation Spine.	Water	46-51	FAT atypical cadherin 1	Homo sapiens	0-3
32589929-0	2020	Molecular characterization and expression analysis of tumor necrosis factor receptor-associated factor 6 (traf6) like gene involved in antibacterial innate immune of fresh water crayfish, Procambarus clarkii.	Water	172-177	TNF-receptor-associated factor 6	Drosophila melanogaster	54-104
32976262-1	2020	OBJECTIVE: To determine the frequencies of fat-water swaps in iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) water-only images of the postinstrumentation spine and discuss the efficiency of in-phase imaging in improving visibility of the thecal sac.	Water	47-52	FAT atypical cadherin 1	Homo sapiens	43-46
32589929-0	2020	Molecular characterization and expression analysis of tumor necrosis factor receptor-associated factor 6 (traf6) like gene involved in antibacterial innate immune of fresh water crayfish, Procambarus clarkii.	Water	172-177	TNF-receptor-associated factor 6	Drosophila melanogaster	106-111
32173726-5	2020	CRISPR-Cas9 gid1 mutants were able to maintain higher leaf water content under water-deficit conditions.	Water	59-64	gibberellin receptor GID1b-1	Solanum lycopersicum	12-16
32976262-1	2020	OBJECTIVE: To determine the frequencies of fat-water swaps in iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) water-only images of the postinstrumentation spine and discuss the efficiency of in-phase imaging in improving visibility of the thecal sac.	Water	47-52	FAT atypical cadherin 1	Homo sapiens	99-102
32976262-1	2020	OBJECTIVE: To determine the frequencies of fat-water swaps in iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) water-only images of the postinstrumentation spine and discuss the efficiency of in-phase imaging in improving visibility of the thecal sac.	Water	89-94	FAT atypical cadherin 1	Homo sapiens	43-46
32432590-0	2020	Li2(Se2O5)(H2O)1.5 CuCl2, a salt-inclusion diselenite structurally based on tetranuclear Li4 complexes.	Water	11-14	ATP binding cassette subfamily A member 12	Homo sapiens	0-3
32976262-1	2020	OBJECTIVE: To determine the frequencies of fat-water swaps in iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) water-only images of the postinstrumentation spine and discuss the efficiency of in-phase imaging in improving visibility of the thecal sac.	Water	89-94	FAT atypical cadherin 1	Homo sapiens	43-46
32432590-0	2020	Li2(Se2O5)(H2O)1.5 CuCl2, a salt-inclusion diselenite structurally based on tetranuclear Li4 complexes.	Water	11-14	lipase family member N	Homo sapiens	89-92
32976262-4	2020	The images were reviewed by two radiologists to identify fat-water swaps that were divided into 3 groups: extraspinal swaps, intraspinal swaps in sagittal images, and intraspinal swaps in axial images.	Water	61-66	FAT atypical cadherin 1	Homo sapiens	57-60
32976262-7	2020	RESULTS: In patient-based data of 276 patients, extraspinal fat-water swaps were noted in 10 patients (3.6%) and intraspinal swaps were noted in 160 patients (58.0%).	Water	64-69	FAT atypical cadherin 1	Homo sapiens	60-63
32687683-0	2020	An Ag2 S@ZnS coated fiber for efficient, long-life solid-phase microextraction of polycyclic aromatic hydrocarbons in water.	Water	118-123	angiotensin II receptor type 1	Homo sapiens	3-8
32976262-12	2020	CONCLUSION: Iterative decomposition of water and fat with echo asymmetry and least-squares estimation sequence can provide good fat suppression in most spine MRI with metallic devices but the loss of cerebrospinal fluid signal intensities due to fat-water swaps are noted in more than half of postinstrumentation spine.	Water	39-44	FAT atypical cadherin 1	Homo sapiens	128-131
32976262-12	2020	CONCLUSION: Iterative decomposition of water and fat with echo asymmetry and least-squares estimation sequence can provide good fat suppression in most spine MRI with metallic devices but the loss of cerebrospinal fluid signal intensities due to fat-water swaps are noted in more than half of postinstrumentation spine.	Water	39-44	FAT atypical cadherin 1	Homo sapiens	128-131
32490447-2	2020	Herein, we explore the microhydration structure in mass-selected protonated pyrimidine-water clusters (H+Pym-Wn, n = 1-4) by a combination of infrared photodissociation spectroscopy (IRPD) between 2450 and 3900 cm-1 and density functional theory (DFT) calculations at the dispersion-corrected B3LYP-D3/aug-cc-pVTZ level.	Water	87-92	PYM homolog 1, exon junction complex associated factor	Homo sapiens	105-108
32976262-12	2020	CONCLUSION: Iterative decomposition of water and fat with echo asymmetry and least-squares estimation sequence can provide good fat suppression in most spine MRI with metallic devices but the loss of cerebrospinal fluid signal intensities due to fat-water swaps are noted in more than half of postinstrumentation spine.	Water	250-255	FAT atypical cadherin 1	Homo sapiens	49-52
32618114-9	2020	Treatment with anti-CD40 antibody significantly alleviated clinical and pathological activities related to EAU.	Water	107-110	CD40 molecule	Homo sapiens	20-24
32976262-13	2020	Routine reconstruction of in-phase images is recommended to improve evaluation of the thecal sac by avoiding pitfall caused by fat-water swaps.	Water	131-136	FAT atypical cadherin 1	Homo sapiens	127-130
32618114-10	2020	Compared with the control mice, antibody-treated EAU mice showed few CD11c+ CD40+ DC and CD11c+ CD40+ MHC-II+ DC frequencies in splenocytes.	Water	49-52	integrin alpha X	Mus musculus	69-74
32618114-10	2020	Compared with the control mice, antibody-treated EAU mice showed few CD11c+ CD40+ DC and CD11c+ CD40+ MHC-II+ DC frequencies in splenocytes.	Water	49-52	CD40 antigen	Mus musculus	76-80
32433911-5	2020	Signal transmission between the allosteric and catalytic sites take place through intramolecular aromatic interactions and a hydrogen bond network that involves residues and water molecules of the MIF solvent channel.	Water	174-179	macrophage migration inhibitory factor	Homo sapiens	197-200
32618114-10	2020	Compared with the control mice, antibody-treated EAU mice showed few CD11c+ CD40+ DC and CD11c+ CD40+ MHC-II+ DC frequencies in splenocytes.	Water	49-52	integrin alpha X	Mus musculus	89-94
32758789-9	2020	Further, all water extracts inhibited zebrafish PR, while only one extract showed weak anti-progestagenic activity for human PR.	Water	13-18	progesterone receptor	Homo sapiens	48-50
32618114-10	2020	Compared with the control mice, antibody-treated EAU mice showed few CD11c+ CD40+ DC and CD11c+ CD40+ MHC-II+ DC frequencies in splenocytes.	Water	49-52	CD40 antigen	Mus musculus	96-100
32618114-12	2020	CONCLUSIONS: The increased expression of CD40 and major histocompatibility complex (MHC) class II molecules in the splenocytes of EAU mice were correlated with inflammatory activity.	Water	130-133	CD40 antigen	Mus musculus	41-45
32433911-7	2020	These results provide mechanistic insights into the regulation of catalytic activity and the role of solvent channel water molecules in MIF catalysis.	Water	117-122	macrophage migration inhibitory factor	Homo sapiens	136-139
32446363-7	2020	The expression of HSF2 increased in the WT + DSS group compared with that in the WT + H2O group.	Water	86-89	heat shock factor 2	Mus musculus	18-22
32639731-0	2020	Solvation Thermodynamics in Different Solvents - Water-Chloroform Partition Coefficients from Grid Inhomogeneous Solvation Theory.	Water	49-54	GRB2 related adaptor protein 2	Homo sapiens	94-98
33036955-10	2021	In CD, high-sensitive C reactive protein levels (hsCRP) and extra-cellular to intra-cellular water ratio (ECW/ICW), an index of cellular inflammation, were inversely correlated with stimulated GLP-1 (p < 0.05 and p < 0.01, respectively) levels.	Water	93-98	glucagon like peptide 1 receptor	Homo sapiens	193-198
32831170-2	2020	We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze.	Water	119-124	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	50-55
33028705-7	2020	We show that hydrogen peroxide (H2O2), produced extracellularly, is necessary for the hypertrophic response of isolated cardiac myocytes and that AQP1 facilitates the transmembrane transport of H2O2 through its water pore, resulting in activation of oxidant-sensitive kinases in cardiac myocytes.	Water	211-216	aquaporin 1	Mus musculus	146-150
32828084-5	2020	Here, we performed all-atom molecular dynamics (MD) simulations starting from closed and open states of the S protein trimer in the presence of explicit water and ions.	Water	153-158	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	108-109
33028705-8	2020	Structural analysis of the amino acid residues lining the water pore of AQP1 supports its permeation by H2O2 Deletion of Aqp1 or selective blockade of the AQP1 intrasubunit pore inhibited H2O2 transport in mouse and human cells and rescued the myocyte hypertrophy in human induced pluripotent stem cell-derived engineered heart muscle.	Water	58-63	aquaporin 1	Mus musculus	72-76
33028705-8	2020	Structural analysis of the amino acid residues lining the water pore of AQP1 supports its permeation by H2O2 Deletion of Aqp1 or selective blockade of the AQP1 intrasubunit pore inhibited H2O2 transport in mouse and human cells and rescued the myocyte hypertrophy in human induced pluripotent stem cell-derived engineered heart muscle.	Water	58-63	aquaporin 1	Mus musculus	121-125
33028705-8	2020	Structural analysis of the amino acid residues lining the water pore of AQP1 supports its permeation by H2O2 Deletion of Aqp1 or selective blockade of the AQP1 intrasubunit pore inhibited H2O2 transport in mouse and human cells and rescued the myocyte hypertrophy in human induced pluripotent stem cell-derived engineered heart muscle.	Water	58-63	aquaporin 1	Mus musculus	155-159
33028705-10	2020	We conclude that cardiac hypertrophy is mediated by the transmembrane transport of H2O2 by the water channel AQP1 and that inhibitors of AQP1 represent new possibilities for treating hypertrophic cardiomyopathies.	Water	95-100	aquaporin 1	Mus musculus	109-113
32913917-5	2020	By assessing the needs of each participant, we were able to aid with food, water and medicine.	Water	75-80	activation induced cytidine deaminase	Homo sapiens	60-63
32546481-9	2020	Taken together, our observations suggest that DPP3 regulates the RAS pathway and water homeostasis by degrading circulating angiotensin peptides.	Water	81-86	dipeptidylpeptidase 3	Mus musculus	46-50
32807174-2	2020	Angiotensin AT1 and AT2 receptors, mainly known for their role in regulating water homeostasis and blood pressure and able to form heterodimers (AT1/2Hets), are present in the central nervous system.	Water	77-82	angiotensin II receptor, type 1a	Rattus norvegicus	12-15
32807174-2	2020	Angiotensin AT1 and AT2 receptors, mainly known for their role in regulating water homeostasis and blood pressure and able to form heterodimers (AT1/2Hets), are present in the central nervous system.	Water	77-82	angiotensin II receptor, type 2	Rattus norvegicus	20-23
32535493-8	2020	The combination of MP-SPR and QCM-D measurements allowed the estimation of the number of water molecules associated with the lysozymes films.	Water	89-94	sepiapterin reductase	Homo sapiens	22-25
32422127-10	2020	Microglia were persistently activated, and COX-2 levels remained elevated in the hippocampus, which paralleled increased spatial memory performance in the Morris Water Maze behavioral task.	Water	162-167	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	43-48
32585478-7	2020	Albumin was found to play crucial roles in the synthesis process: a constrained-microenvironment reactor for particle growth, a water-soluble layer for colloidal stability and a carrier for multi-functionality.	Water	128-133	albumin	Mus musculus	0-7
32464419-10	2020	Such changes in THM, HAA, and NDMA precursors following wildfires pose a potential treatability challenge for drinking water treatment, but the effects are relatively short-term (<=1 year).	Water	119-124	THM	Homo sapiens	16-19
32677465-0	2020	Helicobacter Pylori cagA+ Genotype is Associated With Consumption of Untreated Drinking Water in North-Eastern Brazil.	Water	88-93	S100 calcium binding protein A8	Homo sapiens	20-24
32903548-6	2020	Water contact angles were reduced in the polymers containing PEG functionalization (PLLA-PEG: 69.8  +- 2.3, PCL-PEG: 61.2  +- 7.5) versus those without (PLLA: 79.5  +- 3.2, PCL: 76.4  +- 10.2) while the materials PCL-PEG550, PLCL-PEG550 90:10 and PLCL-PEG550 70:30 demonstrated best endothelial cell adhesion.	Water	0-5	phospholipase C like 1 (inactive)	Homo sapiens	225-229
32903548-6	2020	Water contact angles were reduced in the polymers containing PEG functionalization (PLLA-PEG: 69.8  +- 2.3, PCL-PEG: 61.2  +- 7.5) versus those without (PLLA: 79.5  +- 3.2, PCL: 76.4  +- 10.2) while the materials PCL-PEG550, PLCL-PEG550 90:10 and PLCL-PEG550 70:30 demonstrated best endothelial cell adhesion.	Water	0-5	phospholipase C like 1 (inactive)	Homo sapiens	247-251
32677465-10	2020	Untreated drinking water consumption was associated with the presence of the cagA+ genotype in both the univariate (p = 0.03; OR = 2.55; 95% CI: 1.008-6.48) and multivariate (p = 0.03; OR = 2.89; 95% CI: 1.08-7.67) analyses.	Water	19-24	S100 calcium binding protein A8	Homo sapiens	77-81
33192626-10	2020	EGR3 gene transfection decreased the total moved distance in the open field test and the duration in the Q5 zone of the Morris water maze.	Water	127-132	early growth response 3	Rattus norvegicus	0-4
31800011-2	2020	Recent evidence suggests vaso-protective properties of H2O2 produced by main endothelial NADPH oxidase isoform 4 (Nox4) in the vasculature.	Water	55-59	NADPH oxidase 4	Mus musculus	89-112
31800011-2	2020	Recent evidence suggests vaso-protective properties of H2O2 produced by main endothelial NADPH oxidase isoform 4 (Nox4) in the vasculature.	Water	55-59	NADPH oxidase 4	Mus musculus	114-118
31800011-7	2020	Both H2O2 release and phosphorylation of AKT1 were diminished in aortas of Nox4-/- mice.	Water	5-9	NADPH oxidase 4	Mus musculus	75-79
32870229-1	2020	Employing TBN/TEMPO as the catalysts and oxygen as the oxidant, the biologically and pharmaceutically significant tetrahydro-beta-carboline and beta-carboline alkaloid scaffolds that used to be obtained by multi-step processes can now be selectively obtained in only one-step via direct aerobic oxidative Pictet-Spengler reactions of tryptamines with alcohols under mild conditions, with water generated as the byproduct.	Water	388-393	TATA-box binding protein associated factor 8	Homo sapiens	10-13
31800011-10	2020	Supplementing H2O2 increased phenylephrine-induced contraction in Nox4-/- mice.Exercise induced peroxisome proliferative activated receptor gamma, coactivator 1 alpha (Ppargc1a), as key regulator of mitochondria biogenesis in wild-type but not Nox4-/- mice.	Water	14-18	NADPH oxidase 4	Mus musculus	66-70
31800011-10	2020	Supplementing H2O2 increased phenylephrine-induced contraction in Nox4-/- mice.Exercise induced peroxisome proliferative activated receptor gamma, coactivator 1 alpha (Ppargc1a), as key regulator of mitochondria biogenesis in wild-type but not Nox4-/- mice.	Water	14-18	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	96-166
31800011-10	2020	Supplementing H2O2 increased phenylephrine-induced contraction in Nox4-/- mice.Exercise induced peroxisome proliferative activated receptor gamma, coactivator 1 alpha (Ppargc1a), as key regulator of mitochondria biogenesis in wild-type but not Nox4-/- mice.	Water	14-18	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	168-176
31800011-10	2020	Supplementing H2O2 increased phenylephrine-induced contraction in Nox4-/- mice.Exercise induced peroxisome proliferative activated receptor gamma, coactivator 1 alpha (Ppargc1a), as key regulator of mitochondria biogenesis in wild-type but not Nox4-/- mice.	Water	14-18	NADPH oxidase 4	Mus musculus	244-248
31800011-13	2020	CONCLUSIONS: Nox4 derived H2O2 plays a key role in exercise-induced adaptations of eNOS and Ppargc1a pathway and intracellular calcium release.	Water	26-30	NADPH oxidase 4	Mus musculus	13-17
31800011-13	2020	CONCLUSIONS: Nox4 derived H2O2 plays a key role in exercise-induced adaptations of eNOS and Ppargc1a pathway and intracellular calcium release.	Water	26-30	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	92-100
32901640-0	2020	van der Waals heterostructures based on MSSe (M = Mo, W) and graphene-like GaN: enhanced optoelectronic and photocatalytic properties for water splitting.	Water	138-143	gigaxonin	Homo sapiens	75-78
32865956-4	2020	While a molecular layer of water blocks charge transfer between mica and graphene, a layer of the organic molecules allows for it.	Water	27-32	MHC class I polypeptide-related sequence A	Homo sapiens	64-68
32485369-7	2020	The results indicated that climate change will negatively impact water availability in both reservoirs, especially under RCP8.5.	Water	65-70	CGRP receptor component	Homo sapiens	121-124
33036527-8	2020	After c-myc silenced cells were treated with PM2.5 water soluble solution, The mRNA levels of c-myc, c-fos, and k-ras decreased by 84.1%, 45.4%, and 54.6% (P<0.05) , p53 increased by 192.9% (P<0.05) , and the expression of Caspase-3, Caspase-8, and Caspase-9 decreased by 24.4%, 36.1%, 60.9% (P<0.05) .	Water	51-56	caspase 8	Homo sapiens	234-243
33042982-3	2020	Formulations of CS-based injectable hydrogels with thermo/pH-response are advantageous in terms of their high-water imbibing capability, minimal invasiveness, porous networks, and ability to mold perfectly into an irregular defect.	Water	110-115	citrate synthase	Homo sapiens	16-18
32930879-7	2021	The Ca2+-activated K+ channels of large and intermediate conductance, KCa3.1 and KCa1.1, and the volume-regulated anion channel, whose combined activity results in the extrusion of KCl and osmotic water, control cell volume, and in turn migration, invasion, and apoptotic cell death.	Water	197-202	potassium calcium-activated channel subfamily N member 4	Homo sapiens	70-76
32729869-1	2020	We showed a reversible bond-switching ferroelastic phase transition at near room temperature in a novel organic-inorganic hybrid, (Me3NNH2)2[Co(CN)6Na(H2O)], to afford a latent heat of 43.7 kJ kg-1 and a large entropy change of 146 J K-1 kg-1.	Water	151-154	keratin 1	Homo sapiens	234-242
32626677-0	2020	Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Drinking Water Samples From a Forcibly Displaced, Densely Populated Community Setting in Bangladesh.	Water	72-77	beta-lactamase	Escherichia coli	18-32
33013812-7	2020	Our experimental data, supported by genomic sequencing, showed that, when exposed to pure water, ED1 strain was able to acquire exogenous DNA with frequencies (10-8-10-9) statistically higher than the ones observed for DH5alpha strain (10-10).	Water	90-95	ectodysplasin A	Homo sapiens	97-100
32596620-8	2020	PS and mica could reduce the pore size distribution and porosity and are helpful to establish a waterproof structure, leading to water absorption and the alkali leaching rate being significantly suppressed.	Water	96-101	MHC class I polypeptide-related sequence A	Homo sapiens	7-11
32887288-2	2020	The water extract of WB inhibited degranulation and expression of allergic and inflammatory mediators such as tumor necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase in antigen-stimulated RBL-2H3 cells.	Water	4-9	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	139-155
32112796-8	2020	Intestinal tissues and derived enteroids from MYO5B(P663L) piglets had reduced apical levels and diffuse sub-apical levels of NHE3 and SGLT1, which regulate transport of sodium, glucose, and water, compared with tissues from control piglets.	Water	191-196	myosin VB	Homo sapiens	46-51
32776612-5	2020	Here we show that nighttime melatonin supplementation in the drinking water of melatonin-deficient C57BL/6J mice mimics photoperiodic variations in the expression of the genes Tshb, Dio2, Dio3, and Rfrp, as observed in melatonin-proficient mammals.	Water	70-75	thyroid stimulating hormone, beta subunit	Mus musculus	176-180
32160330-5	2020	RESULTS: In monoculture 1,25(OH)2 D3 suppressed CD4+ T-lymphocyte proliferation, increased the percentage of CD4+ FoxP3+ CD25+ FoxP3+ Tregs and enhanced IL-10 and TGF-beta1 production.	Water	28-33	forkhead box P3	Homo sapiens	114-119
32160330-5	2020	RESULTS: In monoculture 1,25(OH)2 D3 suppressed CD4+ T-lymphocyte proliferation, increased the percentage of CD4+ FoxP3+ CD25+ FoxP3+ Tregs and enhanced IL-10 and TGF-beta1 production.	Water	28-33	interleukin 2 receptor subunit alpha	Homo sapiens	121-125
32160330-5	2020	RESULTS: In monoculture 1,25(OH)2 D3 suppressed CD4+ T-lymphocyte proliferation, increased the percentage of CD4+ FoxP3+ CD25+ FoxP3+ Tregs and enhanced IL-10 and TGF-beta1 production.	Water	28-33	forkhead box P3	Homo sapiens	127-132
33022199-5	2020	From the Brunauer, Emmett and Teller (BET) theory, total pore volume obtained from the literature by nitrogen adsorption, and the sorption data from this work, it has been possible to show that the sorbed water in hair does not distribute uniformly in the hair.	Water	205-210	delta/notch like EGF repeat containing	Homo sapiens	38-41
32279773-2	2020	D-P1 (Ac-D-Phe-D-Phe-D-Phe-Gly-D-Lys) gelated aqueous buffer solution and water at a minimum gelation concentration of 0.5 wt%.	Water	74-79	prostaglandin D2 receptor	Homo sapiens	0-4
32279825-5	2020	Formulations of CS-based injectable hydrogels are advantageous in terms of their high-water imbibing capability, minimal invasiveness, porous networks, and ability to mold perfectly into an irregular defect.	Water	86-91	citrate synthase	Homo sapiens	16-18
32812377-5	2020	Theoretical calculations show that O vacancies at high-index {112} facet of Cox Oy nanocrystallite are preferential sites for trapping single atoms, which guarantee strong interface adhesion of Pd species to cobalt-based support and play a pivotal role in preventing the decrement of activity, even under moisture-rich conditions ( 2% water vapor).	Water	335-340	cytochrome c oxidase subunit 8A	Homo sapiens	76-79
32120108-6	2020	The aim of this study was to identify the toxic effects that the pollutants present in the water of the Madin Dam can generate on a human cell line (SH SY5Y) evaluating the cell viability and the participation of the Aril Hydrocarbon Receptor (AhR) and Pregnane X receptor (PXR) through of the expression of the CYP1A1 and CYP3A4 (canonical genes).	Water	91-96	aryl hydrocarbon receptor	Homo sapiens	244-247
32862402-6	2021	TREM-1 inhibition with LP17 improved neurological deficits, mitigated brain water content, and preserved brain-blood barrier integrity 24 h after SAH, whereas recombinant TREM-1, a mimic of TREM-1, deteriorated these outcomes.	Water	76-81	triggering receptor expressed on myeloid cells 1	Mus musculus	0-6
32321240-2	2020	Herein we report the optimization of a series of phenyl sulfonamides that exhibit a novel mode of binding to non-bromodomain and extra terminal domain (non-BET) bromodomains through displacement of a normally conserved network of four water molecules.	Water	235-240	delta/notch like EGF repeat containing	Homo sapiens	156-159
32982746-0	2020	MEK1/2 Inhibition in Murine Heart and Aorta After Oral Administration of Refametinib Supplemented Drinking Water.	Water	107-112	mitogen-activated protein kinase kinase 1	Mus musculus	0-6
32376801-0	2020	C3(H2O) prevents rescue of complement-mediated C3 glomerulopathy in Cfh-/- Cfd-/- mice.	Water	3-6	complement component factor h	Mus musculus	68-71
32376801-0	2020	C3(H2O) prevents rescue of complement-mediated C3 glomerulopathy in Cfh-/- Cfd-/- mice.	Water	3-6	complement factor D (adipsin)	Mus musculus	75-78
32672784-2	2020	PAZ:PSS can achieve an overall conductivity up to 0.1 S cm-1, and an ion Seebeck coefficient as high as 4500 muV K-1, demonstrating that PAZ:PSS is another promising water-dispersible polymer for thermoelectrics.	Water	166-171	keratin 1	Homo sapiens	113-116
32457767-9	2020	The decrease of water content and the increase of water loss rate in leaf exacerbated the decline of photosynthetic rate in cytosolic APX-suppressed lines.	Water	16-21	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	134-137
32457767-9	2020	The decrease of water content and the increase of water loss rate in leaf exacerbated the decline of photosynthetic rate in cytosolic APX-suppressed lines.	Water	50-55	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	134-137
32174138-1	2020	Emerging evidence has demonstrated that (pro)renin receptor (PRR)-mediated activation of intrarenal renin-angiotensin system (RAS) plays an essential role in renal handling of Na+ and water balance and blood pressure.	Water	184-189	renin	Rattus norvegicus	45-50
32497760-4	2020	The Morris water maze test showed that the swimming times of PTD-ChAT-treated (4 mg/kg) and donepezil-treated (0.5 mg/kg) mice with mild and moderate dementia were significantly shortened (P < 0.01 vs aged dementia mice), and no significant changes were observed between the PTD-ChAT- and donepezil-treated groups.	Water	11-16	choline acetyltransferase	Mus musculus	65-69
32300978-2	2020	The chemical formula of this polymer is {[Tb2(PBA)3(H2O)3] DMF 3H2O}n (1).	Water	52-55	receptor accessory protein 5	Homo sapiens	42-45
32025801-10	2020	After treatment with H2O2, the effects of diphenyleneiodonium and or dimethylthiourea on proline content and activities of P5CS and ProDH were reversed.	Water	21-25	delta-1-pyrroline-5-carboxylate synthase 1	Triticum aestivum	123-127
32807914-3	2020	Water molecules present in the CS beads diffused outward upon contact with the cellulose-IL mixture and acted as an anti-solvent.	Water	0-5	citrate synthase	Homo sapiens	31-33
32372285-3	2020	Nax gene knockout mice showed significantly attenuated water intake after an intracerebroventricular (ICV) injection of a hypertonic NaCl solution; however, the induction of a certain amount of water intake still remained, suggesting that another unknown [Na+]-dependent pathway besides the Nax/TRPV4 pathway contributes to water intake.	Water	194-199	sodium channel, voltage-gated, type VII, alpha	Mus musculus	0-3
32742357-8	2020	The injection of GSK-3beta overexpression agent into the hippocampus of adult mice resulted in a marked increase in escape latency and a significant decrease in the number of times of crossing platforms in the water maze test.	Water	210-215	glycogen synthase kinase 3 alpha	Mus musculus	17-26
32661130-4	2020	Subtracting the water-injected urea uptake or P f values from those of UT-injected oocytes yielded UT-dependent values*.	Water	16-21	methylmalonyl-Coenzyme A mutase	Mus musculus	99-101
31500521-8	2020	In conclusion, ASL-MRI and 15O-H2O-PET measurements of rCBF are highly correlated across different perfusion states, but with variable correlation within and between hemodynamic states, and systematic differences in regional distribution.	Water	31-34	CCAAT/enhancer binding protein zeta	Rattus norvegicus	55-59
32293183-7	2020	In this article, we review recent researches on these MOF composites, including their synthetic methods and potential applications in energy storage devices, heavy metal ion adsorption, and water purification.	Water	190-195	lysine acetyltransferase 8	Homo sapiens	54-57
32661130-5	2020	We demonstrate for the first time that UT-A2 and UT-A3 can transport water, and we confirm that UT-B is permeable to water.	Water	117-122	solute carrier family 14 (urea transporter), member 1	Mus musculus	96-100
32661130-8	2020	Furthermore, UT-mediated water transport activity must be considered when developing UT-inhibitors as novel diuretics.	Water	25-30	methylmalonyl-Coenzyme A mutase	Mus musculus	13-15
32638585-5	2020	The p-GaN/AuNPs/RuCY photocathode was coupled with a hematite photoanode to drive photoelectrochemical CO2 reduction along with water oxidation.	Water	128-133	gigaxonin	Homo sapiens	6-9
32349316-14	2020	Using this extracellular approach, water-soluble fluorescent CdS, CdSAg, and Ag2S Quantum Dots with a tunable emission ranging from 400 to 800 nm were generated.	Water	35-40	angiotensin II receptor type 1	Homo sapiens	77-81
32661130-8	2020	Furthermore, UT-mediated water transport activity must be considered when developing UT-inhibitors as novel diuretics.	Water	25-30	methylmalonyl-Coenzyme A mutase	Mus musculus	85-87
32875240-1	2020	In this work, Kraft lignin (KL) was polymerized with 2-acrylamido-2-methylpropane sulfonic acid (AMPS) to generate an anionic water-soluble KL-g-AMPS polymer.	Water	126-131	lactase like	Homo sapiens	140-144
32390848-2	2020	We found that the water extract of D. morbiferus leaves significantly inhibited tyrosinase activity and melanin formation in alpha-melanocyte stimulating hormone (MSH)-induced B16-F10 cells.	Water	18-23	pro-opiomelanocortin-alpha	Mus musculus	125-161
33029079-1	2020	1"-(2-Acryloxyethyl)-3,3"-dimethyl-6-nitrospiro[2 H-1-benzopyran-2,2"-indoline] (SPA) was synthesized and grafted onto a water-soluble carboxymethyl chitin (CMCH) macromolecule to prepare a photochromic copolymer (CMCH-g-SPA).	Water	121-126	surfactant protein A1	Homo sapiens	81-84
33029079-2	2020	The structure of CMCH-g-SPA was characterized by Fourier-transform infrared (FT-IR) spectroscopy, thermogravimetric (TG) analysis, X-ray diffraction (XRD) analysis, water-solubility evaluation, and UV-vis spectroscopy.	Water	165-170	surfactant protein A1	Homo sapiens	24-27
33029079-3	2020	XRD patterns of CMCH-g-SPA revealed that grafting copolymerization disrupts the CMCH semicrystalline structure, thus improving water solubility.	Water	127-132	surfactant protein A1	Homo sapiens	23-26
33029079-4	2020	UV-vis spectroscopy results supported the negative photochromic behavior of the merocyanine (MC) form of CMCH-g-SPA (CMCH-g-MCA) present in a water solution of the target copolymer.	Water	142-147	surfactant protein A1	Homo sapiens	112-115
32373171-0	2020	Assessment of Changes in Concentration of Total Antioxidant Status, Acute-Phase Protein, and Prolactin in Patients with Osteoarthritis Subjected to a Complex Spa Treatment with Radon Water: Preliminary Results.	Water	183-188	surfactant protein A1	Homo sapiens	158-161
32463670-10	2020	Investigation of the tribochemical mechanism revealed that lubrication enhancement is because of the electrostatic stabilization of SCFs and mucin recruitment, which is accompanied by strong water fixation and reduced water evaporation.	Water	191-196	LOC100508689	Homo sapiens	141-146
32129332-4	2020	The experimental results indicated that compared with the micron-sized crystals obtained using a classical synthesis method, the catalytic activity, stability and dispersity in water of the colloidal Zr-PorMOF were obviously enhanced.	Water	177-182	lysine acetyltransferase 8	Homo sapiens	203-209
32774757-7	2020	In addition, higher expression of miR-135b and miR-29c was observed after the consumption of alkaline water for 5 months.	Water	102-107	microRNA 29c	Homo sapiens	47-54
32463670-10	2020	Investigation of the tribochemical mechanism revealed that lubrication enhancement is because of the electrostatic stabilization of SCFs and mucin recruitment, which is accompanied by strong water fixation and reduced water evaporation.	Water	218-223	LOC100508689	Homo sapiens	141-146
32744246-6	2020	The crystal structure of CDK2 bound to CVT-313 was determined to a resolution of 1.74 A and clearly demonstrated that CVT-313 binds in the ATP-binding pocket, interacting with Leu83, Asp86 and Asp145 directly, and the binding was further stabilized by a water-mediated interaction with Asn132.	Water	254-259	cyclin dependent kinase 2	Homo sapiens	25-29
32224376-1	2020	A novel kind of cationic metal-organic framework(MOF) based mixed-matrix membrane(MMM) namely cationic MOF-MMM was firstly designed and used for simultaneous dispersive membrane extraction(DME) of six phenoxy carboxylic acid(PCA) herbicides from water samples followed by determination using ultrahigh-performance liquid chromatography tandem mass spectrometry.	Water	246-251	lysine acetyltransferase 8	Homo sapiens	49-52
32224376-1	2020	A novel kind of cationic metal-organic framework(MOF) based mixed-matrix membrane(MMM) namely cationic MOF-MMM was firstly designed and used for simultaneous dispersive membrane extraction(DME) of six phenoxy carboxylic acid(PCA) herbicides from water samples followed by determination using ultrahigh-performance liquid chromatography tandem mass spectrometry.	Water	246-251	lysine acetyltransferase 8	Homo sapiens	103-106
32224376-7	2020	By relying on the obtained results, the present work implied cationic MOF-MMM based DME can be a versatile and worthy utility for extraction of pollutants from different water samples with high throughput.	Water	170-175	lysine acetyltransferase 8	Homo sapiens	70-73
32018941-10	2020	Our results demonstrate that AR and AhR activities are commonly found in Iowa drinking water, and that their detection varies by season and utility/sample characteristics.	Water	87-92	aryl hydrocarbon receptor	Homo sapiens	36-39
32410834-4	2020	We found that Rg1 effectively ameliorates spatial learning and memory deficits in aging mice demonstrated by their improved performance in step down avoidance tests and Morris water maze experiments.	Water	176-181	protein phosphatase 1, regulatory subunit 3A	Mus musculus	14-17
31772043-10	2020	A 1-point increase in CS was associated with 1.9% (95% CI 0.2% to 3.7%) lowered lesion water uptake in follow-up CT .	Water	87-92	citrate synthase	Homo sapiens	22-24
32296124-5	2020	Analysis of air temperature at 850 mb and precipitable water (RCP4.5 and RCP8.5) indicates an intensification of Indian Ocean Dipole in future, which will enhance the monsoon throughout India.	Water	55-60	CGRP receptor component	Homo sapiens	62-65
32685851-0	2020	Self-Assembly of Ag2S Colloidal Nanoparticles Stabilized by MPS in Water Solution.	Water	67-72	angiotensin II receptor type 1	Homo sapiens	17-21
32019005-0	2020	Monitoring the spatiotemporal terrestrial water storage changes in the Yarlung Zangbo River Basin by applying the P-LSA and EOF methods to GRACE data.	Water	42-47	PLSA1	Homo sapiens	114-127
32731324-6	2020	Pure water and organic solvent fluxes generally followed the trend NF270 > NF90 > BW30 > XLE, with the solvent choice playing a major role in the separation process.	Water	5-10	BW30	Homo sapiens	82-86
32707664-2	2020	METHODS: Uptake of two water-soluble functionalized C70 fullerenes with different types of aromatic addends (ethylphenylmalonate and thienylacetate) in human fetal lung fibroblasts, intracellular ROS visualization, superoxide scavenging potential, NOX4 expression, NRF2 expression, oxidative DNA damage, repair genes, cell proliferation and cell cycle were studied.	Water	23-28	NADPH oxidase 4	Homo sapiens	248-252
33455346-0	2020	Efficient Oral Delivery of Poorly Water-Soluble Drugs Using Carnitine/Organic Cation Transporter 2-Mediated Polymeric Micelles.	Water	34-39	solute carrier family 22 (organic cation transporter), member 2	Mus musculus	70-98
32339710-4	2020	The incorporation of beta-CD-crHA significantly improved the surface hydrophilicity, water uptake ability, oxygen permeability, and flexibility of pHEMA hydrogel, but did not compromise light transmission.	Water	85-90	LOW QUALITY PROTEIN: adrenocortical dysplasia protein homolog	Oryctolagus cuniculus	21-28
32624516-1	2020	A new ionic pentanuclear FeIII cluster, namely, triethylazanium tetrakis(mu2-5-amino-1,2,3,4-tetrazolido)tetrakis(mu3-4-chloro-2-{[(1H-tetrazol-1-id-5-yl)imino]methyl}phenolato)di-mu3-oxido-pentairon(III) acetonitrile monosolvate monohydrate, (C6H16N)[Fe5(C8H4ClN5O)4(CH2N5)4O2] CH3CN H2O, was synthesized using microvial synthesis methods and characterized by elemental analysis, FT-IR spectroscopy, single-crystal X-ray diffraction and thermogravimetric analysis.	Water	285-288	adaptor related protein complex 1 subunit mu 2	Homo sapiens	73-76
32708548-5	2020	Thus, for TFC membrane on the PAN-4 substrate the optimal transport characteristics in pervaporation dehydration of isopropanol (12-90 wt.% water) were achieved: 0.22-1.30 kg/(m2h), 99.9 wt.% water in the permeate.	Water	140-145	NLR family pyrin domain containing 8	Homo sapiens	30-35
32374711-1	2020	Oral lubrication mediated by mucin and protein containing salivary conditioning films (SCFs) with strong water retainability can get impaired due to disease such as xerostomia, that is, a subjective dry mouth feel associated with the changed salivary composition and low salivary flow rate.	Water	105-110	LOC100508689	Homo sapiens	29-34
32276671-9	2020	IGF1 overexpressing animals performed better during radial arm water maze reversal testing, a neurogenesis-dependent cognitive test.	Water	63-68	insulin-like growth factor 1	Mus musculus	0-4
32708548-5	2020	Thus, for TFC membrane on the PAN-4 substrate the optimal transport characteristics in pervaporation dehydration of isopropanol (12-90 wt.% water) were achieved: 0.22-1.30 kg/(m2h), 99.9 wt.% water in the permeate.	Water	192-197	NLR family pyrin domain containing 8	Homo sapiens	30-35
32664537-7	2020	The cognitive function of Bean-PS was assessed using the Morris water maze (MWM) test and a passive avoidance task (PAT).	Water	64-69	brain expressed, associated with NEDD4, 1	Rattus norvegicus	26-30
32215444-8	2020	Complex formation between the positively charged FNR:NADP+ pre-complex and the negatively charged PetF is not only entropically favored, but in addition the solvent reorganization into more bulk-like water assists the molecular recognition process.	Water	200-205	ferredoxin reductase	Homo sapiens	49-52
32612190-1	2020	While designing the anti-inflammatory agents targeting cyclooxygenase-2 (COX-2), we first identified a water loop around the heme playing critical role in the enzyme catalysis.	Water	103-108	prostaglandin-endoperoxide synthase 2	Mus musculus	55-71
32612190-1	2020	While designing the anti-inflammatory agents targeting cyclooxygenase-2 (COX-2), we first identified a water loop around the heme playing critical role in the enzyme catalysis.	Water	103-108	prostaglandin-endoperoxide synthase 2	Mus musculus	73-78
32848308-1	2020	Aim: This study aimed to investigate the association of single nucleotide polymorphism of the myostatin (MSTN) and fatty acid-binding protein 4 (FABP4) genes on the total water, ash, fat, protein, and cholesterol contents of sirloin (gluteus medius muscle) and silverside (biceps femoris muscle) meats of cull female Aceh cattle.	Water	171-176	myostatin	Bos taurus	94-103
32848308-1	2020	Aim: This study aimed to investigate the association of single nucleotide polymorphism of the myostatin (MSTN) and fatty acid-binding protein 4 (FABP4) genes on the total water, ash, fat, protein, and cholesterol contents of sirloin (gluteus medius muscle) and silverside (biceps femoris muscle) meats of cull female Aceh cattle.	Water	171-176	myostatin	Bos taurus	105-109
32664537-10	2020	RESULTS: Treatment with Bean-PS enhanced memory function in the Morris water maze (MWM) test.	Water	71-76	brain expressed, associated with NEDD4, 1	Rattus norvegicus	24-28
32695023-9	2020	Moreover, GlpF-W48 (analogous to AQP7-F74) undergoes rare but long-lasting conformational changes that block the pore to H2O and glycerol.	Water	121-124	aquaporin 7	Homo sapiens	33-37
32095822-5	2020	The slac1 and ost1 mutants tended to keep their stomata open in fluctuating light, resulting in lower water-use efficiency (WUE) than the wild-type.	Water	102-107	Protein kinase superfamily protein	Arabidopsis thaliana	14-18
32376028-2	2020	By means of aqueous two-phase extraction (ATPE), using aqueous two-phase system (ATPS) of butanol-water as the extractant, 11 common antidiabetics could be effectively extracted to the upper and lower phases, respectively.	Water	98-103	ATP synthase F1 subunit epsilon	Homo sapiens	42-46
31982658-1	2020	O-H   O=C Hydrogen bonding (H-bonding) results in spectral shifts in both nuO-H and nuC=O modes.	Water	0-9	nucleobindin 1	Homo sapiens	84-87
32234538-16	2020	In cells isolated from the colonic LMMP, incubation with the TLR2 agonist increased the percentage of neurons originating from ENPCs to approximately 10%, compared to approximately 0.01% in cells incubated with the TLR4 agonist or distilled water.	Water	241-246	toll-like receptor 2	Mus musculus	61-65
31862296-3	2020	Thus, it has been shown that H2O2 directly recruits neutrophils via the Src-family tyrosine kinase Lyn and indirectly by the activation of several signaling pathways involved in inflammation, such as nuclear factor kappaB, mitogen activated kinases and the transcription factor AP1.	Water	29-33	LYN proto-oncogene, Src family tyrosine kinase	Danio rerio	99-102
32606873-3	2020	Results: In vitro antioxidant experiments showed that both of the extracts could scavenge free radicals and exhibited inhibitory effects on glucosidase and aldose reductase with differential effects between water extract and alcohol extract.	Water	207-212	aldo-keto reductase family 1 member B1	Rattus norvegicus	140-172
32487560-6	2020	Water-loaded endothelin A receptor knockout mice, compared with control mice, had markedly enhanced urine volume and reduced urine osmolality associated with increased urinary endothelin-1 and PGE2 excretion, increased cyclooxygenase-2 protein expression, and decreased inner medullary aquaporin-2 protein content.	Water	0-5	endothelin receptor type A	Mus musculus	13-34
32418927-0	2020	Detection of hepatocyte growth factor in oral rinses using water for possible periodontal diagnosis.	Water	59-64	hepatocyte growth factor	Homo sapiens	13-37
32418927-1	2020	The aim of this study is to analyze the relationship between Hepatocyte Growth Factor (HGF) levels in oral rinses using water and clinical parameters of periodontitis; and furthermore, to evaluate the potential of a prototype HGF immunochromatographic paper test strip (HGF-TS) for screening of periodontitis, in comparison with a commercially-available occult blood (hemoglobin) test strip (Hb-TS).	Water	120-125	hepatocyte growth factor	Homo sapiens	61-85
32418927-1	2020	The aim of this study is to analyze the relationship between Hepatocyte Growth Factor (HGF) levels in oral rinses using water and clinical parameters of periodontitis; and furthermore, to evaluate the potential of a prototype HGF immunochromatographic paper test strip (HGF-TS) for screening of periodontitis, in comparison with a commercially-available occult blood (hemoglobin) test strip (Hb-TS).	Water	120-125	hepatocyte growth factor	Homo sapiens	87-90
32487560-6	2020	Water-loaded endothelin A receptor knockout mice, compared with control mice, had markedly enhanced urine volume and reduced urine osmolality associated with increased urinary endothelin-1 and PGE2 excretion, increased cyclooxygenase-2 protein expression, and decreased inner medullary aquaporin-2 protein content.	Water	0-5	prostaglandin-endoperoxide synthase 2	Mus musculus	219-235
32437601-9	2020	Changing the dihydrothiophene (3) into pyrrolidine (4), N-methyl pyrrolidine (5) or dihydrofuran (6) induced flexibility in the position of a binding-site water molecule and changes in the hydrogen-bonding network between compound, water and GluA2.	Water	155-160	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	242-247
32662446-8	2020	The expression of cbln11 mRNA was analysed by qPCR in the first generation (F0) of European sea bass broodstock exposed since larval stages to water pH of 8.0 (control) or 7.6 (predicted for year 2100) and in their offspring (F1) maintained in the environmental conditions of their parents.	Water	143-148	cerebellin 11	Danio rerio	18-24
32555429-2	2020	Electrophysiological investigation and immunohistochemical techniques of c-fos expression were combined to determine which neural elements within the lumbar segments and in the central nucleus of the amygdala (CeA) are activated under skeletal muscle fatigue development with prior application of C60 fullerenes (dissolved in dimethyl sulfoxide and in distilled water, FDS).	Water	362-367	carcinoembryonic antigen gene family 4	Rattus norvegicus	210-213
32629946-5	2020	The QPECH/PAEK-API1 membrane showed quite high hydroxide ion conductivity, from 0.022 S cm-1 (30  C) to 0.033 S cm-1 (80  C), and excellent mechanical strength, associated with the low water uptake of less than 40%, even at 80  C. Such high conductivity at relatively low water uptake is attributed to the concentrated cationic groups, in a cross-linked structure, facilitating feasible ion transport.	Water	185-190	baculoviral IAP repeat containing 2	Homo sapiens	10-19
32560078-7	2020	In leaves, isoprene caused the downregulation of COR15A and P5CS genes, suggesting that the enhanced tolerance to water-deprivation stress observed in isoprene-emitting plants may be mediated chiefly by an enhanced membrane integrity and tolerance to osmotic stress.	Water	114-119	cold-regulated 15a	Arabidopsis thaliana	49-55
32629946-5	2020	The QPECH/PAEK-API1 membrane showed quite high hydroxide ion conductivity, from 0.022 S cm-1 (30  C) to 0.033 S cm-1 (80  C), and excellent mechanical strength, associated with the low water uptake of less than 40%, even at 80  C. Such high conductivity at relatively low water uptake is attributed to the concentrated cationic groups, in a cross-linked structure, facilitating feasible ion transport.	Water	272-277	baculoviral IAP repeat containing 2	Homo sapiens	10-19
32612446-1	2020	Background: Refillable water containers are commonly used in rural areas of Lao PDR, and they act as Aedes mosquito breeding sites.	Water	23-28	interleukin 4 induced 1	Homo sapiens	76-79
32930175-6	2020	We further show that the detection of Cr3+ using gamma-PGA-Au NPs has excellent selectivity, and the recovery percentage is higher than 82% for different water samples such as lake water, river water, tap water or mineral water.	Water	154-159	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	38-41
31756475-3	2020	WM-NP-60 was a water-soluble polysaccharide.	Water	15-20	glyoxylate reductase 1 homolog	Homo sapiens	3-8
32930175-6	2020	We further show that the detection of Cr3+ using gamma-PGA-Au NPs has excellent selectivity, and the recovery percentage is higher than 82% for different water samples such as lake water, river water, tap water or mineral water.	Water	181-186	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	38-41
32517121-14	2020	These results suggest that storing contaminated water samples for 2 to 4 weeks in the dark at an ambient temperature prior to culturing can improve the isolation of Leptospira spp.	Water	48-53	histocompatibility minor 13	Homo sapiens	176-179
32930175-6	2020	We further show that the detection of Cr3+ using gamma-PGA-Au NPs has excellent selectivity, and the recovery percentage is higher than 82% for different water samples such as lake water, river water, tap water or mineral water.	Water	181-186	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	38-41
32517121-19	2020	The animal species using a water source influenced the likelihood of water samples being contaminated with Leptospira spp.	Water	27-32	histocompatibility minor 13	Homo sapiens	118-121
32517121-19	2020	The animal species using a water source influenced the likelihood of water samples being contaminated with Leptospira spp.	Water	69-74	histocompatibility minor 13	Homo sapiens	118-121
32930175-6	2020	We further show that the detection of Cr3+ using gamma-PGA-Au NPs has excellent selectivity, and the recovery percentage is higher than 82% for different water samples such as lake water, river water, tap water or mineral water.	Water	181-186	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	38-41
32930175-6	2020	We further show that the detection of Cr3+ using gamma-PGA-Au NPs has excellent selectivity, and the recovery percentage is higher than 82% for different water samples such as lake water, river water, tap water or mineral water.	Water	181-186	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	38-41
32930175-7	2020	Our study demonstrates that gamma-PGA-Au NPs can be utilized as an efficient probe for colorimetric sensing of Cr3+ ions in a water environment.	Water	126-131	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	111-114
32587380-4	2020	It was recently reported that angulin-2/ILDR1 knockout mice have water transport abnormalities in the kidney.	Water	65-70	immunoglobulin-like domain containing receptor 1	Mus musculus	40-45
32292064-8	2020	Importantly, losartan pretreatment blocked the effect of phoenixin on water drinking, and knockdown of Gpr173 using short interfering RNA constructs significantly attenuated water drinking in response to overnight fluid deprivation.	Water	174-179	G protein-coupled receptor 173	Homo sapiens	103-109
32581267-1	2020	The physiological role of the renal ClC-Ka/ClC-K1 channels is to confer a high Cl- permeability to the thin Ascending Limb of Henle (tAL), which in turn is essential for establishing the high osmolarity of the renal medulla that drives water reabsorption from collecting ducts.	Water	236-241	chloride voltage-gated channel Ka	Homo sapiens	43-49
31819159-3	2020	Here, we evaluated whether the mitochondrial enzyme monoamine oxidase-A (MAO-A), which generates H2O2 as a by-product of catecholamine metabolism, is a source of deleterious 4-HNE in HF.	Water	97-101	monoamine oxidase A	Mus musculus	52-71
32576829-0	2020	Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.	Water	73-78	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	22-28
31819159-3	2020	Here, we evaluated whether the mitochondrial enzyme monoamine oxidase-A (MAO-A), which generates H2O2 as a by-product of catecholamine metabolism, is a source of deleterious 4-HNE in HF.	Water	97-101	monoamine oxidase A	Mus musculus	73-78
32348877-3	2020	Recently, for a clinical application, a few potent (highly cell-permeable and water-soluble) PAK1 blockers have been developed from natural or synthetic PAK1 blockers (triptolide, vitamin D3 and ketorolac) via a series of "chemical evolutions" that boost pharmacological activities >500 times.	Water	78-83	p21 (RAC1) activated kinase 1	Homo sapiens	93-97
32348877-3	2020	Recently, for a clinical application, a few potent (highly cell-permeable and water-soluble) PAK1 blockers have been developed from natural or synthetic PAK1 blockers (triptolide, vitamin D3 and ketorolac) via a series of "chemical evolutions" that boost pharmacological activities >500 times.	Water	78-83	p21 (RAC1) activated kinase 1	Homo sapiens	153-157
32575551-2	2020	Catalase is an antioxidant enzyme that plays a significant role in cellular protection against oxidative damage by the degradation of hydrogen peroxide to oxygen and water.	Water	166-171	catalase	Bos taurus	0-8
32146590-1	2020	PURPOSE: AQP7, a water/glycerol transporting protein, regulates adipocyte glycerol efflux and influences lipid and glucose homeostasis.	Water	17-22	aquaporin 7	Homo sapiens	9-13
32086095-0	2020	In-situ fabrication of nanoarchitectured MOF filter for water purification.	Water	56-61	lysine acetyltransferase 8	Homo sapiens	41-44
33187584-9	2020	Network pharmacology analysis suggested that EF water extract not only regulated the proliferation and differentiation of osteoblasts but also caused a regulatory effect on osteoclasts via multiple signaling pathways, such as RANKL-RANK-induced signaling and TGF-beta signaling.	Water	48-53	transforming growth factor alpha	Homo sapiens	259-267
32363808-5	2020	Furthermore, the layered nanochannels of the SmA liquid crystal allow efficient water permeation compared to other types of liquid-crystalline membrane consisting of nanopores.	Water	80-85	survival of motor neuron 1, telomeric	Homo sapiens	45-48
32506854-0	2020	Electroacupuncture relieves irritable bowel syndrome by increasing expression of nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6 in water-avoidance stress mice.	Water	181-186	Mediterranean fever	Mus musculus	152-157
32548473-12	2020	In addition, E-AM/AMPS powder had a high specific surface area so that it can be dissolved in water faster, greatly reducing the time and difficulty of configuring drilling fluid.	Water	94-99	adenylosuccinate lyase	Homo sapiens	13-22
32373844-6	2020	We demonstrate this method for the water-CaF2 and water-protein interfaces.	Water	35-40	CCR4-NOT transcription complex subunit 8	Homo sapiens	41-45
32466181-7	2020	With 50% hCS, the calcium ion release was higher than 50% CS in the distilled water at the initial time.	Water	78-83	holocarboxylase synthetase	Homo sapiens	9-12
32014500-6	2020	The elevated levels of H2O2 (a biomarker of oxidative stress) and the free radicals (NO  and O2 -) reduced the concentration of dominant pathogens and regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1).	Water	23-27	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	161-197
32014500-6	2020	The elevated levels of H2O2 (a biomarker of oxidative stress) and the free radicals (NO  and O2 -) reduced the concentration of dominant pathogens and regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1).	Water	23-27	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	199-203
32466181-7	2020	With 50% hCS, the calcium ion release was higher than 50% CS in the distilled water at the initial time.	Water	78-83	holocarboxylase synthetase	Homo sapiens	10-12
32466181-9	2020	The water sorption and solubility had an increasing trend as increasing proportions of hCS were added.	Water	4-9	holocarboxylase synthetase	Homo sapiens	87-90
32455981-9	2020	Thus, the validated dual colorimetric and ratiometric method can find various analytical applications for the ultrasensitive and rapid detection of AMG antibiotics in water samples.	Water	167-172	amelogenin X-linked	Homo sapiens	148-151
32608846-5	2020	CA/ClAP addition not only reduced the concentration of soluble reactive P (SRP) in the overlying water, but also decreased the concentration of SRP in the pore water.	Water	97-102	BCL10 immune signaling adaptor	Homo sapiens	3-7
32608846-5	2020	CA/ClAP addition not only reduced the concentration of soluble reactive P (SRP) in the overlying water, but also decreased the concentration of SRP in the pore water.	Water	160-165	BCL10 immune signaling adaptor	Homo sapiens	3-7
32608846-6	2020	The addition of CA/ClAP in sediments caused an increase in the content of P in the sediments, but the increased P mainly existed in the form of calcium-bound P (HCl-P), which was difficult to be re-released into the water column under anoxic and common pH (5-9) conditions.	Water	216-221	BCL10 immune signaling adaptor	Homo sapiens	19-23
32608846-7	2020	The reduction of SRP in the pore water after the addition of CA/ClAP played an important role in the prevention of sedimentary P liberation into the overlying water by the CA/ClAP amendment.	Water	33-38	BCL10 immune signaling adaptor	Homo sapiens	64-68
32608846-7	2020	The reduction of SRP in the pore water after the addition of CA/ClAP played an important role in the prevention of sedimentary P liberation into the overlying water by the CA/ClAP amendment.	Water	159-164	BCL10 immune signaling adaptor	Homo sapiens	64-68
32608846-8	2020	The results of this work indicate that CA/ClAP can be used as an amendment material for interception of the release of P from sediments into overlying water.	Water	151-156	BCL10 immune signaling adaptor	Homo sapiens	42-46
32455721-1	2020	Porous Pt electrocatalysts have been developed as an example of carbon-free porous metal catalysts in anticipation of polymer electrolyte membrane (PEM) fuel cells and PEM water electrolyzers through the assembly of the metal precursor and surfactant.	Water	172-177	mucin 1, cell surface associated	Homo sapiens	168-171
32226486-4	2020	Furthermore, the quantification of brain water content and the extravasation of Evans blue dye revealed a significant reduction in SAH-induced brain edema and blood-brain barrier permeability at 72 h due to treatment with the calpastatin peptide when compared with untreated SAH controls.	Water	41-46	calpastatin	Rattus norvegicus	226-237
32314827-6	2020	The same structure acts as an efficient photocatalyst in the generation of H 2 from water under visible illumination with rate of 0.136 mmole/g h of H 2 , which is 20 times higher than pristine SnS 2 under visible light.	Water	84-89	sodium voltage-gated channel alpha subunit 11	Homo sapiens	194-199
31978470-4	2020	Meanwhile, the coordination structure of Bridge-chitosan-N(OH)3(H2O) and morphology of regenerated fibrillar sponge of CS/Cr(III) were further certified.	Water	64-67	citrate synthase	Homo sapiens	119-121
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Water	105-110	deleted in esophageal cancer 1	Homo sapiens	170-175
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Water	105-110	deleted in esophageal cancer 1	Homo sapiens	244-249
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Water	328-333	deleted in esophageal cancer 1	Homo sapiens	170-175
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Water	328-333	deleted in esophageal cancer 1	Homo sapiens	244-249
31057084-7	2020	Glycan influence the interaction of the complex with the water molecules whereas free protein MOG interaction with water molecules was not affected by the glycosylation.	Water	115-120	myelin oligodendrocyte glycoprotein	Homo sapiens	94-97
32383886-0	2020	Preparation of CaF2 Microspheres with Nanopetals for Water Vapor Adsorption.	Water	53-58	CCR4-NOT transcription complex subunit 8	Homo sapiens	15-19
31492290-8	2020	In addition, NF-TGH electrode can potentially be utilized in water purification due to its high degradation activity, stable porous structure and easy separation from waste water.	Water	61-66	carboxylesterase 1	Homo sapiens	16-19
32383886-5	2020	The adsorption of water vapor on CaF2 is irreversible because CaF2 can interact with the adsorbed water molecules strongly.	Water	18-23	CCR4-NOT transcription complex subunit 8	Homo sapiens	33-37
31492290-8	2020	In addition, NF-TGH electrode can potentially be utilized in water purification due to its high degradation activity, stable porous structure and easy separation from waste water.	Water	173-178	carboxylesterase 1	Homo sapiens	16-19
32383886-5	2020	The adsorption of water vapor on CaF2 is irreversible because CaF2 can interact with the adsorbed water molecules strongly.	Water	18-23	CCR4-NOT transcription complex subunit 8	Homo sapiens	62-66
32383886-5	2020	The adsorption of water vapor on CaF2 is irreversible because CaF2 can interact with the adsorbed water molecules strongly.	Water	98-103	CCR4-NOT transcription complex subunit 8	Homo sapiens	33-37
32383886-5	2020	The adsorption of water vapor on CaF2 is irreversible because CaF2 can interact with the adsorbed water molecules strongly.	Water	98-103	CCR4-NOT transcription complex subunit 8	Homo sapiens	62-66
32383886-6	2020	The dual-site Langmuir model was used to describe the measured adsorption isotherms of water vapor on FL-CaF2 at low water vapor pressures and 298, 308, and 318 K. FL-CaF2 has a much higher water-adsorption capacity than those reported in the literature.	Water	87-92	CCR4-NOT transcription complex subunit 8	Homo sapiens	105-109
32300368-1	2020	Like several parts in the Middle East, the West Bank is in a significant water scarcity status.	Water	73-78	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	48-52
32383886-6	2020	The dual-site Langmuir model was used to describe the measured adsorption isotherms of water vapor on FL-CaF2 at low water vapor pressures and 298, 308, and 318 K. FL-CaF2 has a much higher water-adsorption capacity than those reported in the literature.	Water	87-92	CCR4-NOT transcription complex subunit 8	Homo sapiens	167-171
32300368-2	2020	Palestinians use groundwater as the main water source, supplying more than 90% of the consumed water in the West Bank.	Water	23-28	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	113-117
32300368-2	2020	Palestinians use groundwater as the main water source, supplying more than 90% of the consumed water in the West Bank.	Water	41-46	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	113-117
32383886-6	2020	The dual-site Langmuir model was used to describe the measured adsorption isotherms of water vapor on FL-CaF2 at low water vapor pressures and 298, 308, and 318 K. FL-CaF2 has a much higher water-adsorption capacity than those reported in the literature.	Water	117-122	CCR4-NOT transcription complex subunit 8	Homo sapiens	105-109
32300368-3	2020	The aim of this study is to enhance the knowledge on drinking water quality in the West Bank.	Water	62-67	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	88-92
32383886-6	2020	The dual-site Langmuir model was used to describe the measured adsorption isotherms of water vapor on FL-CaF2 at low water vapor pressures and 298, 308, and 318 K. FL-CaF2 has a much higher water-adsorption capacity than those reported in the literature.	Water	117-122	CCR4-NOT transcription complex subunit 8	Homo sapiens	167-171
32300368-6	2020	The findings of this study revealed that groundwater in the north of the West Bank comply with several drinking water requirements including total hardness, pH, and sodium and chloride content.	Water	47-52	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	78-82
32383886-6	2020	The dual-site Langmuir model was used to describe the measured adsorption isotherms of water vapor on FL-CaF2 at low water vapor pressures and 298, 308, and 318 K. FL-CaF2 has a much higher water-adsorption capacity than those reported in the literature.	Water	117-122	CCR4-NOT transcription complex subunit 8	Homo sapiens	105-109
32383886-6	2020	The dual-site Langmuir model was used to describe the measured adsorption isotherms of water vapor on FL-CaF2 at low water vapor pressures and 298, 308, and 318 K. FL-CaF2 has a much higher water-adsorption capacity than those reported in the literature.	Water	117-122	CCR4-NOT transcription complex subunit 8	Homo sapiens	167-171
32429458-6	2020	Nek1 shRNA HeLa cells were grafted into NOD/SCID/IL-2Rgammac-/- (NSG) mice and Nek1 KD was induced by Dox-infused drinking water resulting in a significant cytostatic effect if combined with a 6 h fractionation (3 x 2 Gy) regime.	Water	123-128	NIMA related kinase 1	Homo sapiens	0-4
31825903-0	2020	Highly dispersive Pt-Pd nanoparticles on graphene oxide sheathed carbon fiber microelectrodes for electrochemical detection of H2O2 released from living cells.	Water	127-131	protein tyrosine phosphatase receptor type D	Homo sapiens	18-23
31825903-1	2020	We report a facile strategy for the synthesis of surfactant-free, small and highly dispersive Pt-Pd nanoparticles on graphene oxide (Pt-Pd NPs/GO) by electroless deposition method, which is sheathed on carbon fiber microelectrodes (CFMs) as an electrochemical sensing platform for highly sensitive and selective detection of hydrogen peroxide (H2O2) released from the living cells.	Water	344-348	protein tyrosine phosphatase receptor type D	Homo sapiens	94-99
32161135-1	2020	Above 2 GPa the phase diagram of water simplifies considerably and exhibits only two solid phases up to 60 GPa, ice VII and ice VIII.	Water	33-38	cytochrome c oxidase subunit 8A	Homo sapiens	128-132
32068061-5	2020	The spherical-like CUR-conjugated system (CUR-CS-ZnO) with the average particle size of 40 nm presented significantly enhanced water dispersibility versus free CUR.	Water	127-132	citrate synthase	Homo sapiens	46-48
32210322-10	2020	The results obtained revealed BiVO4/Ag2S as a suitable photoanode for removing recalcitrant pharmaceutical molecules in water.	Water	120-125	angiotensin II receptor type 1	Homo sapiens	36-40
32302123-5	2020	X-ray crystallography indicates that the amino groups of some compounds occupy a water-filled pocket surrounding an nNOS-specific aspartate residue (absent in eNOS).	Water	81-86	nitric oxide synthase 1	Homo sapiens	116-120
32210208-0	2020	Mechanical Properties, Microstructure, and Chloride Content of Alkali-Activated Fly Ash Paste Made with Sea Water.	Water	108-113	scheggia	Drosophila melanogaster	104-107
32210208-1	2020	The aim of the present study is to investigate the potential of sea water as a feasible alternative to produce alkali-activated fly ash material.	Water	68-73	scheggia	Drosophila melanogaster	64-67
32210208-4	2020	The results provided new insights demonstrating that sea water can be effectively used to produce alkali activated fly ash material.	Water	57-62	scheggia	Drosophila melanogaster	53-56
32210208-5	2020	The presence of chloride in sea water contributed to increase compressive strength, refine microstructure, and mineralogical characteristics.	Water	32-37	scheggia	Drosophila melanogaster	28-31
32414058-9	2020	Rapid blood clearance and poor binding to serum albumin identify Fe(L1)(OH2) for development as an extracellular fluid contrast agent.	Water	72-75	albumin	Mus musculus	42-55
32210208-6	2020	Furthermore, a higher degree of polymerization on the sea water-based sample was observed by FT-IR and 29Si NMR analysis.	Water	58-63	scheggia	Drosophila melanogaster	54-57
32210208-7	2020	However, the higher amount of free chloride ion even after immobilization in sea water-based alkali-activated material, should be considered before application in reinforced structural elements.	Water	81-86	scheggia	Drosophila melanogaster	77-80
32251313-6	2020	We further found that compared with control mice, CAST KO mice drank significantly less water when nurturing and had a greater preference for sucrose during pregnancy.	Water	88-93	calpastatin	Mus musculus	50-54
32414109-5	2020	Another two groups were treated with lectin product (0.5 mL/L drinking water) for three days before the challenge.	Water	71-76	galectin 3	Gallus gallus	37-43
32392886-1	2020	The reaction between Dy(NO3)3 6H2O and the bulky Schiff base ligand, N-naphthalidene-2-amino-5-chlorobenzoic acid (nacbH2), in the presence of the organic base NEt3 has led to crystallization and structural, spectroscopic and magnetic characterization of a new heptanuclear [Dy7(OH)6(OMe)2(NO3)1.5(nacb)2(nacbH)6(MeOH)(H2O)2](NO3)1.5 (1) compound in ~40% yield.	Water	31-34	tetraspanin 2	Homo sapiens	160-164
32005731-7	2020	Overall, these findings demonstrate that Sml1 could be a novel regulator that mediates Rev1 dephosphorylation to inhibit its activity during oxidative stress.IMPORTANCE Rev1 was critical for cell growth in S. cerevisiae, and the deletion of REV1 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2 Furthermore, we found that Sml1 physically interacted with Rev1 and inhibited Rev1 phosphorylation, thereby inhibited Rev1 DNA antioxidant activity.	Water	321-325	ribonucleotide reductase inhibiting protein SML1	Saccharomyces cerevisiae S288C	41-45
32291614-2	2020	Arsenic (2.90 ng ml-1) and Se (1.41 ng ml-1) in water had the highest concentrations in the return flow drains (Hardy River and Xochimilco Lagoon, respectively).	Water	48-53	interleukin 17F	Homo sapiens	39-43
32258885-0	2020	Synthesis of a New Water-Soluble Melatonin Derivative with Low Toxicity and a Strong Effect on Sleep Aid.	Water	19-24	activation induced cytidine deaminase	Homo sapiens	101-104
32372285-2	2020	We previously demonstrated that Nax signals are involved in the control of water intake behavior through the Nax/TRPV4 pathway.	Water	75-80	sodium channel, voltage-gated, type VII, alpha	Mus musculus	32-35
32180006-5	2020	The results of electrochemical tests indicate that CDP-DA effectively retards the anodic and cathodic reactions and improves the interfacial charge transfer resistance of mild steel in condensate water, which can be categorized as the mixed-type inhibitor.	Water	196-201	cut like homeobox 1	Homo sapiens	51-54
32372285-2	2020	We previously demonstrated that Nax signals are involved in the control of water intake behavior through the Nax/TRPV4 pathway.	Water	75-80	sodium channel, voltage-gated, type VII, alpha	Mus musculus	109-112
32372285-3	2020	Nax gene knockout mice showed significantly attenuated water intake after an intracerebroventricular (ICV) injection of a hypertonic NaCl solution; however, the induction of a certain amount of water intake still remained, suggesting that another unknown [Na+]-dependent pathway besides the Nax/TRPV4 pathway contributes to water intake.	Water	55-60	sodium channel, voltage-gated, type VII, alpha	Mus musculus	0-3
32372285-3	2020	Nax gene knockout mice showed significantly attenuated water intake after an intracerebroventricular (ICV) injection of a hypertonic NaCl solution; however, the induction of a certain amount of water intake still remained, suggesting that another unknown [Na+]-dependent pathway besides the Nax/TRPV4 pathway contributes to water intake.	Water	194-199	sodium channel, voltage-gated, type VII, alpha	Mus musculus	0-3
32168914-10	2020	The electrokinetic treatment of a sludge from a water treatment plant contaminated with Mn was effective when pH control on the cathode was used.	Water	48-53	phenylalanine hydroxylase	Homo sapiens	110-112
32334318-2	2020	This work aimed to prepare a novel hollow starch nanoparticles (HSNPs) from debranched waxy corn starch (DBS) via an oil-in-water (O/W) emulsion templating method.	Water	124-129	MCF.2 cell line derived transforming sequence like	Homo sapiens	105-108
31945542-10	2020	Unexpectedly, NEIL1 and NEIL3 were trapped following H2O2 treatment, but not detectably in cells exposed to CuOP.	Water	53-57	nei like DNA glycosylase 3	Homo sapiens	24-29
32223143-1	2020	We report the rational design and synthesis of a new, water-stable metal-organic framework (MOF), Fe-HAF-1, constructed from supramolecular, Fe3+-hydroxamate-based polyhedra with mononuclear metal nodes.	Water	54-59	lysine acetyltransferase 8	Homo sapiens	67-96
32191981-2	2020	Without any indication of eardrum perforation, ear irrigation with warm water is a safe, effective and fast aid.	Water	72-77	activation induced cytidine deaminase	Homo sapiens	108-111
32290497-4	2020	The results suggested that intense water dissociation occurred at the cathodic side of the commercial anion-exchange membrane (HDX) during the overlimiting test.	Water	35-40	highly divergent homeobox	Homo sapiens	127-130
32093246-1	2020	The influence of the compensating cation (Na+, Li+, Mg2+) nature on the water adsorption properties of LTA and FAU-type zeolites was investigated.	Water	72-77	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	111-114
32223947-5	2020	EGF was given 8 weeks after sialoadenectomy in a dose of 1 mug /ml/day in drinking water for 2 weeks.	Water	83-88	epidermal growth factor like 1	Rattus norvegicus	0-3
32093246-6	2020	This improvement facilitates the adsorption of water with an increase in the water uptake up to 30% for the LTA and FAU type zeolites exchanged with magnesium.	Water	47-52	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	116-119
32093246-6	2020	This improvement facilitates the adsorption of water with an increase in the water uptake up to 30% for the LTA and FAU type zeolites exchanged with magnesium.	Water	77-82	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	116-119
32258491-4	2020	The strategy in the novel system of using mucin loading insulin into the inner core of prepared water in oil microemulsion to provide sustained released, increased in vivo stability and enhanced drug absorption in the gastrointestinal tract.	Water	96-101	LOC100508689	Homo sapiens	42-47
31953370-5	2020	Water-restricted male rats learned to associate a light-tone cue (CS) with water delivery into a port.	Water	0-5	citrate synthase	Rattus norvegicus	66-68
32321826-10	2020	We observe experimentally and predict theoretically fast reaction of syn-MVK-oxide with SO2 and formic acid, similar to smaller alkyl-substituted CIs, and by contrast, slow removal in the presence of water.	Water	200-205	mevalonate kinase	Homo sapiens	73-76
31953370-5	2020	Water-restricted male rats learned to associate a light-tone cue (CS) with water delivery into a port.	Water	75-80	citrate synthase	Rattus norvegicus	66-68
31825903-1	2020	We report a facile strategy for the synthesis of surfactant-free, small and highly dispersive Pt-Pd nanoparticles on graphene oxide (Pt-Pd NPs/GO) by electroless deposition method, which is sheathed on carbon fiber microelectrodes (CFMs) as an electrochemical sensing platform for highly sensitive and selective detection of hydrogen peroxide (H2O2) released from the living cells.	Water	344-348	protein tyrosine phosphatase receptor type D	Homo sapiens	133-138
31825903-5	2020	Moreover, the Pt-Pd NPs/GO sheathed CFMs exhibit an excellent electrocatalytic activity for the reduction of H2O2 with a low detection limit of 0.3 muM and good selectivity.	Water	109-113	protein tyrosine phosphatase receptor type D	Homo sapiens	14-19
32210322-0	2020	Towards visible light driven photoelectrocatalysis for water treatment: Application of a FTO/BiVO4/Ag2S heterojunction anode for the removal of emerging pharmaceutical pollutants.	Water	55-60	angiotensin II receptor type 1	Homo sapiens	99-103
31830435-0	2020	Quantitative determination of H2O2 for detection of alanine aminotransferase using thin film electrodes.	Water	30-34	glutamic--pyruvic transaminase	Homo sapiens	52-76
31874304-0	2020	Effect of salinity, Mg2+ and SO42- on "smart water"-induced carbonate wettability alteration in a model oil system.	Water	45-50	mucin 7, secreted	Homo sapiens	20-23
31830435-4	2020	The aim of this study was to adapt the alanine aminotransferase (ALT) enzyme to the platinum (Pt) thin film electrode system and quantitatively determine the enzyme levels via enzymatically generated H2O2 with differential pulse voltammetry (DPV).	Water	200-204	glutamic--pyruvic transaminase	Homo sapiens	39-63
31992638-7	2020	As a result, we identified more than 5,000 putative target sites of osmotic stress-activated SnRK2.4 and SnRK2.6, abscisic acid-activated protein kinases SnRK2.6 and casein kinase 1-like 2 (CKL2), elicitor-activated protein kinase CDPK11 and MPK6, cold-activated protein kinase MPK6, H2O2-activated protein kinase OXI1 and MPK6, and salt-induced protein kinase SOS1 and MPK6, as well as the low-potassium-activated protein kinase CIPK23.	Water	284-288	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	361-365
32105282-0	2020	Reaction pathways and kinetics study on a syngas combustion system: CO + HO2 in an H2O environment.	Water	83-86	heme oxygenase 2	Homo sapiens	73-76
32033139-7	2020	In the ex-vivo study, a similar correlation was observed between the concentration of a glucose/water solution and the S21 parameters 56.6 GHz.	Water	96-101	ribosomal protein S21	Homo sapiens	119-122
32105282-3	2020	Firstly, the potential energy surface (PES) of CO + HO2 (water-free) is revisited.	Water	57-62	heme oxygenase 2	Homo sapiens	52-55
32105282-5	2020	In the presence of water, the title reaction has three different pre-reactive complexes (i.e., RC2: COHO2 + H2O, RC3: COH2O + HO2, and RC4: HO2H2O + CO), depending on the initial hydrogen bond formation.	Water	19-24	neurogranin	Homo sapiens	113-116
32105282-5	2020	In the presence of water, the title reaction has three different pre-reactive complexes (i.e., RC2: COHO2 + H2O, RC3: COH2O + HO2, and RC4: HO2H2O + CO), depending on the initial hydrogen bond formation.	Water	19-24	heme oxygenase 2	Homo sapiens	102-105
31858814-5	2020	The biological significance of miR-132-3p, TUG1, and HDAC3 was assessed using miR-132-3p mimic, siRNA targeting TUG1, and HDAC3 inhibitor RGF966, respectively, in H2O2-challenged cells in vitro or I/R-induced AMI in vivo.	Water	163-167	histone deacetylase 3	Homo sapiens	53-58
31917504-2	2020	Herein, we report a new stable and flexible eightfold interpenetrated three-dimensional (3D) metal-organic framework (MOF), [Zn(oba)(pip)]n (JUK-8) based on 4,4"-oxybis(benzenedicarboxylate) (oba) and 4-pyridyl functionalized benzene-1,3-dicarbohydrazide (pip) linkers, featuring distinct switchability in response to guest molecules (H2O and CO2) or temperature.	Water	335-338	lysine acetyltransferase 8	Homo sapiens	93-123
31858814-5	2020	The biological significance of miR-132-3p, TUG1, and HDAC3 was assessed using miR-132-3p mimic, siRNA targeting TUG1, and HDAC3 inhibitor RGF966, respectively, in H2O2-challenged cells in vitro or I/R-induced AMI in vivo.	Water	163-167	histone deacetylase 3	Homo sapiens	122-127
31858814-6	2020	RESULTS: miR-132-3p was down-regulated, while TUG1 up-regulated in H2O2-challenged cardiomyocytes.	Water	67-71	taurine up-regulated 1	Homo sapiens	46-50
31858814-7	2020	Overexpressing miR-132-3p or knocking down TUG1 significantly improved viability, inhibited apoptosis, and reduced ROS production in H2O2-stressed cardiomyocytes in vitro, and alleviated I/R-induced AMI in vivo.	Water	133-137	taurine up-regulated 1	Homo sapiens	43-47
31715260-3	2020	Recently we have demonstrated that the activation of extracellular signal-regulated kinase (Erk) 1/2 as well as p38 is required for hydrogen peroxide (H2O2)-increased cytosolic phospholipase A2 (cPLA2) phosphorylation in bEnd3 cells.	Water	151-155	mitogen-activated protein kinase 3	Mus musculus	53-100
31943675-3	2020	As demonstrated, MOF with a cationic skeleton is impervious to extremely acidic, oxidative, reductive, and high ionic strength conditions such as 12 M HCl (301 days), aqua regia (86 days), H 2 O 2 (30 days), and seawater (30 days), which is surprisingly unprecedented in MOFs.	Water	189-196	lysine acetyltransferase 8	Homo sapiens	17-20
31715260-3	2020	Recently we have demonstrated that the activation of extracellular signal-regulated kinase (Erk) 1/2 as well as p38 is required for hydrogen peroxide (H2O2)-increased cytosolic phospholipase A2 (cPLA2) phosphorylation in bEnd3 cells.	Water	151-155	mitogen-activated protein kinase 14	Mus musculus	112-115
31715260-3	2020	Recently we have demonstrated that the activation of extracellular signal-regulated kinase (Erk) 1/2 as well as p38 is required for hydrogen peroxide (H2O2)-increased cytosolic phospholipase A2 (cPLA2) phosphorylation in bEnd3 cells.	Water	151-155	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	167-193
31715260-3	2020	Recently we have demonstrated that the activation of extracellular signal-regulated kinase (Erk) 1/2 as well as p38 is required for hydrogen peroxide (H2O2)-increased cytosolic phospholipase A2 (cPLA2) phosphorylation in bEnd3 cells.	Water	151-155	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	195-200
31715260-4	2020	Using this in vitro ischemic-like model, we found that both blockade and interference of CRHR1 inhibited H2O2-enhancd p38, Erk1/2 and cPLA2 phosphorylation and in turn suppressed monolayer hyperpermeability and ZO-1 redistribution.	Water	105-109	mitogen-activated protein kinase 14	Mus musculus	118-121
31896068-14	2020	In addition, the expression of Fus was downregulated in the AMI mouse models and in H2O2-treated cardiomyocytes.	Water	84-88	fused in sarcoma	Mus musculus	31-34
31715260-4	2020	Using this in vitro ischemic-like model, we found that both blockade and interference of CRHR1 inhibited H2O2-enhancd p38, Erk1/2 and cPLA2 phosphorylation and in turn suppressed monolayer hyperpermeability and ZO-1 redistribution.	Water	105-109	mitogen-activated protein kinase 3	Mus musculus	123-129
31715260-4	2020	Using this in vitro ischemic-like model, we found that both blockade and interference of CRHR1 inhibited H2O2-enhancd p38, Erk1/2 and cPLA2 phosphorylation and in turn suppressed monolayer hyperpermeability and ZO-1 redistribution.	Water	105-109	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	134-139
32476736-11	2020	Tap water was used for washing utensils.	Water	4-9	tracheal antimicrobial peptide	Bos taurus	0-3
31566298-6	2020	Furthermore, aging markers such as senescence-associated beta-galactosidase p53, p21Cip1/WAF1 , and p16INK4A were upregulated under H2 O2 exposure and galangin could reverse its effects.	Water	132-137	galactosidase beta 1	Homo sapiens	57-75
31578723-5	2020	The results in our study demonstrated that hydrogen peroxide (H2 O2 ) treatment reduced BMSC viability and this effect could be reversed via additional supplementation of miR181-c.	Water	62-67	microRNA 181c	Homo sapiens	171-179
31348608-0	2020	The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein.	Water	36-41	interleukin 4 induced 1	Homo sapiens	102-105
31758626-9	2020	Water-use rates and ecotypic differences in stress response (Psileaf decline, leaf loss) are lower in NLL than yellow lupin (YL).	Water	0-5	5'-nucleotidase, cytosolic IIIA	Homo sapiens	118-123
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Water	198-202	transcription factor EB	Sus scrofa	137-160
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Water	198-202	transcription factor EB	Sus scrofa	162-166
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Water	198-202	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	320-324
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Water	198-202	transcription factor EB	Sus scrofa	367-371
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Water	198-202	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	387-391
32115039-4	2020	Meanwhile, the increased hydration state and the decreased apparent viscosity suggested the disruption of protein-protein interactions and the strengthening of myosin-water interactions in pressurized myosin, ultimately resulting in increased solubility of the pressurized myosin with both organic potassium salts.	Water	167-172	myosin, heavy chain 7B, cardiac muscle, beta	Gallus gallus	160-166
31502715-1	2020	PURPOSE: To develop a fast MR fingerprinting (MRF) sequence for simultaneous estimation of water T1 (T1H2O ) and fat fraction (FF) in fat infiltrated skeletal muscles.	Water	91-96	trafficking protein particle complex subunit 9	Homo sapiens	97-99
31502715-1	2020	PURPOSE: To develop a fast MR fingerprinting (MRF) sequence for simultaneous estimation of water T1 (T1H2O ) and fat fraction (FF) in fat infiltrated skeletal muscles.	Water	91-96	trafficking protein particle complex subunit 9	Homo sapiens	101-106
31502715-10	2020	CONCLUSION: The MRF T1-FF sequence derived T1H2O and FF values in voxels containing a mixture of water and fat protons.	Water	97-102	trafficking protein particle complex subunit 9	Homo sapiens	43-48
31502715-11	2020	This method can be used to comprehend and characterize the effects of tissue water compartmentation and distribution on muscle T1 values in patients affected by chronic fat infiltration.	Water	77-82	trafficking protein particle complex subunit 9	Homo sapiens	127-129
32115039-4	2020	Meanwhile, the increased hydration state and the decreased apparent viscosity suggested the disruption of protein-protein interactions and the strengthening of myosin-water interactions in pressurized myosin, ultimately resulting in increased solubility of the pressurized myosin with both organic potassium salts.	Water	167-172	myosin, heavy chain 7B, cardiac muscle, beta	Gallus gallus	201-207
31317382-6	2020	When water-soluble zinc porphyrin is coupled with FDH, visible light drives CO2 to produce formic acid.	Water	5-10	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	50-53
32115039-4	2020	Meanwhile, the increased hydration state and the decreased apparent viscosity suggested the disruption of protein-protein interactions and the strengthening of myosin-water interactions in pressurized myosin, ultimately resulting in increased solubility of the pressurized myosin with both organic potassium salts.	Water	167-172	myosin, heavy chain 7B, cardiac muscle, beta	Gallus gallus	201-207
32059723-0	2020	Chinese medicine Di-Huang-Yi-Zhi protects PC12 cells from H2O2-induced apoptosis by regulating ROS-ASK1-JNK/p38 MAPK signaling.	Water	58-62	mitogen activated protein kinase 14	Rattus norvegicus	108-111
31846305-6	2020	The instrument is employed to monitor the minuscule heat evolution in an acid-base reaction and the decomposition of H2O2 by bovine liver catalase.	Water	117-121	catalase	Bos taurus	138-146
31904232-5	2020	With lead-optimization studies, we have developed several novel EP2 antagonists with improved water solubility, brain penetration, high EP2 potency, and selectivity.	Water	94-99	prostaglandin E receptor 2	Homo sapiens	64-67
31872818-12	2020	As similar mechanisms are also prevalent in other motors, and GTPase and ATPase enzymes, the present finding spells out the definitive requirement of a proton relay process through an extended water-chain as one of the key components in an enzymatic ATP hydrolysis reaction.	Water	193-198	dynein axonemal heavy chain 8	Homo sapiens	73-79
32166333-0	2020	Assessment of River Water Quality in an Agricultural Region of Brazil Using Biomarkers in a Native Neotropical Fish, Astyanax spp.	Water	20-25	histocompatibility minor 13	Homo sapiens	126-129
32166333-4	2020	Thus, this study aimed to estimate the influence of pesticide residues and water parameters to biomarker responses in the native fish Astyanax spp.	Water	75-80	histocompatibility minor 13	Homo sapiens	143-146
32046059-1	2020	The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.	Water	178-183	gap junction protein, beta 6	Mus musculus	106-117
31912910-8	2020	In addition, GLA treatment suppressed the H2 O2 -induced expression of inducible nitric oxide synthase, NADPH oxidase (NOX) 2, and NOX4 in HCASMCs.	Water	42-47	NADPH oxidase 4	Homo sapiens	131-135
31635745-2	2020	IN, a functional prebiotic modifier, was found to significantly (p < 0.05) decrease emulsion viscosity and particle size, with OSA/CS/IN particles having significantly (p < 0.05) improved water solubility (4.96%) and wettability (749 s) compared to OSA/CS particles.	Water	188-193	citrate synthase	Homo sapiens	127-136
31635745-2	2020	IN, a functional prebiotic modifier, was found to significantly (p < 0.05) decrease emulsion viscosity and particle size, with OSA/CS/IN particles having significantly (p < 0.05) improved water solubility (4.96%) and wettability (749 s) compared to OSA/CS particles.	Water	188-193	citrate synthase	Homo sapiens	131-133
32046059-1	2020	The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.	Water	178-183	gap junction protein, beta 6	Mus musculus	119-123
31696991-6	2020	Two iron complexes [(mtL42)FeCl](PF6) and [(mtL42)Fe(OTf)2]) were obtained and their reactivity studied towards aromatic substrates in the presence of H2O2.	Water	151-155	sperm associated antigen 17	Homo sapiens	33-36
32266027-6	2020	However, uro-D was only detected in the culture of rat intestinal microflora suspension with the water decoction of cassia seed, and uro-B-glur was only detected in the culture of human intestinal microflora with the water decoction of cassia seed.	Water	97-102	uroporphyrinogen decarboxylase	Rattus norvegicus	9-14
31896574-6	2020	We show that exposure to the oxidant H2O2 induced MMT1 expression, but not MMT2 expression, and identified the transcription factor Yap1 as being involved in oxidant-mediated MMT1 expression.	Water	37-41	Mmt1p	Saccharomyces cerevisiae S288C	175-179
32202681-4	2020	Water transport is activated and, IP3 R, TRPA1, TRPV4, and Aquaporin-4 are all involved in shaping the dynamics of infrared pulse-evoked intracellular calcium signal.	Water	0-5	transient receptor potential cation channel subfamily V member 4	Homo sapiens	48-53
31858814-4	2020	METHODS: In primary cardiomyocytes challenged with H2O2, expressions of miR-132-3p, TUG1 and other target proteins were measured by RT-qPCR or Western blot; cell viability by MTT assay; apoptosis by Annexin V and PI staining; the abundance of acetylated H3K9 or histone deacetylase 3 (HDAC3) within the promoter of target genes by chromatin immunoprecipitation; the direct interaction between miR-132-3p and HDAC3 or TUG1 by luciferase reporter assay.	Water	51-55	taurine up-regulated 1	Homo sapiens	84-88
31923239-3	2020	We measured: (i) the external limiting membrane-retinal pigment epithelium region thickness (ELM-RPE; OCT), which decreases substantially with upregulation of a pH-sensitive water removal co-transporter on the apical portion of the RPE, and (ii) the outer retina R1 (= 1/(spin lattice relaxation time (T1), an MRI parameter proportional to oxygen / free radical content.	Water	174-179	plexin A2	Mus musculus	102-105
31858814-4	2020	METHODS: In primary cardiomyocytes challenged with H2O2, expressions of miR-132-3p, TUG1 and other target proteins were measured by RT-qPCR or Western blot; cell viability by MTT assay; apoptosis by Annexin V and PI staining; the abundance of acetylated H3K9 or histone deacetylase 3 (HDAC3) within the promoter of target genes by chromatin immunoprecipitation; the direct interaction between miR-132-3p and HDAC3 or TUG1 by luciferase reporter assay.	Water	51-55	histone deacetylase 3	Homo sapiens	262-283
31858814-4	2020	METHODS: In primary cardiomyocytes challenged with H2O2, expressions of miR-132-3p, TUG1 and other target proteins were measured by RT-qPCR or Western blot; cell viability by MTT assay; apoptosis by Annexin V and PI staining; the abundance of acetylated H3K9 or histone deacetylase 3 (HDAC3) within the promoter of target genes by chromatin immunoprecipitation; the direct interaction between miR-132-3p and HDAC3 or TUG1 by luciferase reporter assay.	Water	51-55	histone deacetylase 3	Homo sapiens	285-290
31825623-4	2020	With the help of certain amounts of H2O (from 100 to 2000 ppm) in the electrolyte, adequate Li2O formed on the lithium anode surface after high current pretreatment, which is necessary for a robust and uniform solid electrolyte interphase (SEI) layer to protect Li metal during the long-term discharge-charge cycling process.	Water	36-39	ATP binding cassette subfamily A member 12	Homo sapiens	92-95
31858814-4	2020	METHODS: In primary cardiomyocytes challenged with H2O2, expressions of miR-132-3p, TUG1 and other target proteins were measured by RT-qPCR or Western blot; cell viability by MTT assay; apoptosis by Annexin V and PI staining; the abundance of acetylated H3K9 or histone deacetylase 3 (HDAC3) within the promoter of target genes by chromatin immunoprecipitation; the direct interaction between miR-132-3p and HDAC3 or TUG1 by luciferase reporter assay.	Water	51-55	histone deacetylase 3	Homo sapiens	408-413
32937621-10	2020	Erosive tooth wear in enamel was associated with a lower fluoride level (<=1 ppm) in the drinking water (OR 2.1, 95% CI 1.1-4.2).	Water	98-103	olfactory receptor family 6 subfamily B member 2	Homo sapiens	105-111
31150667-0	2020	Nax-positive glial cells in the organum vasculosum laminae terminalis produce epoxyeicosatrienoic acids to induce water intake in response to increases in [Na+] in body fluids.	Water	114-119	sodium channel, voltage-gated, type VII, alpha	Mus musculus	0-3
31150667-2	2020	We recently demonstrated that Nax signals are involved in the control of not only salt intake but also water intake behavior.	Water	103-108	sodium channel, voltage-gated, type VII, alpha	Mus musculus	30-33
31150667-3	2020	Our pharmacological experiments suggested that Nax signals led to activation of neurons bearing TRPV4 by using epoxyeicosatrienoic acids (EETs) as gliotransmitters to stimulate water intake.	Water	177-182	sodium channel, voltage-gated, type VII, alpha	Mus musculus	47-50
31858814-4	2020	METHODS: In primary cardiomyocytes challenged with H2O2, expressions of miR-132-3p, TUG1 and other target proteins were measured by RT-qPCR or Western blot; cell viability by MTT assay; apoptosis by Annexin V and PI staining; the abundance of acetylated H3K9 or histone deacetylase 3 (HDAC3) within the promoter of target genes by chromatin immunoprecipitation; the direct interaction between miR-132-3p and HDAC3 or TUG1 by luciferase reporter assay.	Water	51-55	taurine up-regulated 1	Homo sapiens	417-421
31499302-10	2020	Our study demonstrated that, beyond the P fertilization rate, the increase in organic C content and even more so in pH induced by a decade of organic fertilizer applications in soil decreased the Pi sorption capacity and consequently increased Pi-water in soil.	Water	247-252	phenylalanine hydroxylase	Homo sapiens	116-118
31866360-11	2020	Although H2O2 at 100 muM did not yield any response, it enhanced the mechanically activated TRPA1-dependent Ca2+ response.	Water	9-13	transient receptor potential cation channel subfamily A member 1	Homo sapiens	92-97
31682917-4	2020	For example, TRPM2, TRPC5, TRPV1, and TRPA1 are known as redox sensors activated by hydrogen peroxide (H2O2), nitric oxide (NO), and electrophiles.	Water	103-107	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
31150667-5	2020	These experiments revealed that the Nax channel in the organum vasculosum laminae terminalis (OVLT) functions as a [Na+] sensor for the control of water intake behavior.	Water	147-152	sodium channel, voltage-gated, type VII, alpha	Mus musculus	36-39
31150667-9	2020	Collectively, these results indicate that Nax-positive glial cells produce EETs to activate TRPV4-positive neurons which may stimulate water intake, in response to increases in [Na+] of body fluids.	Water	135-140	sodium channel, voltage-gated, type VII, alpha	Mus musculus	42-45
31682917-4	2020	For example, TRPM2, TRPC5, TRPV1, and TRPA1 are known as redox sensors activated by hydrogen peroxide (H2O2), nitric oxide (NO), and electrophiles.	Water	103-107	transient receptor potential cation channel subfamily A member 1	Homo sapiens	38-43
31776182-4	2020	The ppd5 mutants showed increased H2O2 accumulation in guard cells and enhanced stomatal closure in response to drought stress.	Water	34-38	PsbP domain protein (Mog1/PsbP/DUF1795-like photosystem II reaction center PsbP family protein)	Arabidopsis thaliana	4-8
30661460-0	2020	Identification of Pak1 inhibitors using water thermodynamic analysis.	Water	40-45	p21 (RAC1) activated kinase 1	Homo sapiens	18-22
32266936-6	2020	Direct binding of HODE isomers to PPARgamma LBD was determined by water-ligand observed via gradient spectroscopy (WaterLOGSY) nuclear magnetic resonance experiments.	Water	66-71	peroxisome proliferator activated receptor gamma	Mus musculus	34-43
32165497-1	2020	Cytochrome c oxidase (CcO) reduces O2 to water, coupled with a proton-pumping process.	Water	41-46	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
32165497-1	2020	Cytochrome c oxidase (CcO) reduces O2 to water, coupled with a proton-pumping process.	Water	41-46	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
30661460-10	2020	Five structurally diverse novel Pak1 inhibitors (4835785, 32198676, 32407813, 76038049, and 32945545) were obtained from virtual screening, water thermodynamics and WM/MM DeltaG binding energy.	Water	140-145	p21 (RAC1) activated kinase 1	Homo sapiens	32-36
31776182-6	2020	Double mutant ppd5-2ost1-3 exhibited phenotypes resembling the ost1-3 single mutant with decreased stomatal closure, increased water loss, reduced H2O2 accumulation in guard cells and hypersensitivity to drought stress.	Water	147-151	PsbP domain protein (Mog1/PsbP/DUF1795-like photosystem II reaction center PsbP family protein)	Arabidopsis thaliana	14-18
31776182-7	2020	These results indicate that the chloroplast protein PPD5 negatively regulates drought resistance by modulating guard cell H2O2 accumulation via an OST1-dependent pathway.	Water	122-126	PsbP domain protein (Mog1/PsbP/DUF1795-like photosystem II reaction center PsbP family protein)	Arabidopsis thaliana	52-56
32331523-10	2020	Compared to the mice of ICH, exogenous rDKK3 administration reduced the brain water content and affected the neurological functions in ICH mice.	Water	78-83	dickkopf WNT signaling pathway inhibitor 3	Rattus norvegicus	39-44
32082162-2	2019	Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3beta/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes.	Water	0-5	glycogen synthase kinase 3 alpha	Homo sapiens	82-90
32155053-3	2020	Herein, we reported a bimetallic metal-organic framework (MOF) (NKMOF-1-Ni) which possesses a narrow pore size (5.36 A) and ultrahigh stability (e.g., stable in water for 1.5 years).	Water	161-166	lysine acetyltransferase 8	Homo sapiens	22-62
31908576-5	2020	In cultured VSMCs, hydrogen peroxide (H2O2) dose-dependently induced senescence, which was associated with increased numbers of senescence-associated beta-galactosidase-positive cells, decreased expression of SMP30, and activation of p53-p21 and p16 pathways.	Water	38-42	galactosidase beta 1	Homo sapiens	150-168
31908576-5	2020	In cultured VSMCs, hydrogen peroxide (H2O2) dose-dependently induced senescence, which was associated with increased numbers of senescence-associated beta-galactosidase-positive cells, decreased expression of SMP30, and activation of p53-p21 and p16 pathways.	Water	38-42	regucalcin	Homo sapiens	209-214
32038695-6	2019	In addition, overexpression of WRKY25 mediated higher tolerance to oxidative stress and the intracellular H2O2 level is lower in WRKY25 overexpressing plants and higher in wrky25 mutants compared to wildtype plants suggesting that WRKY25 is also involved in controlling intracellular redox conditions.	Water	106-110	WRKY DNA-binding protein 25	Arabidopsis thaliana	31-37
31144003-7	2020	The population dynamics of SAR11-OTU in dmdA-detected GW waters suggest that water mass mixing plays a major role in shaping bacterial communities involved in phytoplankton-derived DMSP demethylation.	Water	57-62	sarcoglycan gamma	Homo sapiens	40-44
32181660-6	2020	The reversible nature of water sorption was further manifested by TGA and PXRD studies.	Water	25-30	T-box transcription factor 1	Homo sapiens	66-69
32092287-12	2020	The differential protein localisation of Cldn2 in the RPE during the day-night cycle suggest that Cldn2 may facilitate paracellular water and sodium transport during the day.	Water	132-137	claudin 2	Mus musculus	41-46
32092287-12	2020	The differential protein localisation of Cldn2 in the RPE during the day-night cycle suggest that Cldn2 may facilitate paracellular water and sodium transport during the day.	Water	132-137	claudin 2	Mus musculus	98-103
31994353-11	2020	In conclusion, the SGLT2 inhibitor ipragliflozin induced a sustained glucosuria, diuresis, and natriuresis, with compensatory increases in fluid intake and vasopressin-induced TcH2O in proportion to the reduced fluid balance to maintain BFV.	Water	176-181	solute carrier family 5 member 2	Rattus norvegicus	19-24
32038695-6	2019	In addition, overexpression of WRKY25 mediated higher tolerance to oxidative stress and the intracellular H2O2 level is lower in WRKY25 overexpressing plants and higher in wrky25 mutants compared to wildtype plants suggesting that WRKY25 is also involved in controlling intracellular redox conditions.	Water	106-110	WRKY DNA-binding protein 25	Arabidopsis thaliana	129-135
31557719-2	2020	SELENBP1 is associated with cellular redox and thiol homeostasis in several respects, including its established role as a methanethiol oxidase that is involved in degradation of methanethiol, a methionine catabolite, generating hydrogen sulfide (H2S) and hydrogen peroxide (H2O2).	Water	274-278	selenium binding protein 1	Homo sapiens	0-8
32038695-6	2019	In addition, overexpression of WRKY25 mediated higher tolerance to oxidative stress and the intracellular H2O2 level is lower in WRKY25 overexpressing plants and higher in wrky25 mutants compared to wildtype plants suggesting that WRKY25 is also involved in controlling intracellular redox conditions.	Water	106-110	WRKY DNA-binding protein 25	Arabidopsis thaliana	172-178
32038695-6	2019	In addition, overexpression of WRKY25 mediated higher tolerance to oxidative stress and the intracellular H2O2 level is lower in WRKY25 overexpressing plants and higher in wrky25 mutants compared to wildtype plants suggesting that WRKY25 is also involved in controlling intracellular redox conditions.	Water	106-110	WRKY DNA-binding protein 25	Arabidopsis thaliana	129-135
31557719-3	2020	As both H2S and reactive oxygen species (such as H2O2) are major regulators of Caenorhabditis elegans lifespan and stress resistance, we hypothesized that a SELENBP1 ortholog in C. elegans would likely be involved in regulating these aspects.	Water	49-53	selenium binding protein 1	Homo sapiens	157-165
32038695-7	2019	Consistently, WRKY25 overexpressers had higher and wrky mutants lower H2O2 scavenging capacity.	Water	70-74	WRKY DNA-binding protein 25	Arabidopsis thaliana	14-20
32357726-2	2020	The instrument is primarily targeted for measuring the evolving ratio of HDO/H2O during experiments in the "Aerosol Interaction and Dynamics in the Atmosphere" (AIDA) cloud chamber.	Water	77-80	axin interactor, dorsalization associated	Homo sapiens	161-165
31812751-8	2020	Moreover, GA-g-CMCS had a protective effect against hydrogen peroxide (H2O2)-induced oxidative damage in RAW264.7 cells.	Water	71-75	cerebral malaria susceptibility in CBA/N	Mus musculus	15-19
32258491-5	2020	We report how microemulsion composed of varying ratios of snail mucin and Tween  80 (1:9-9:1) using oil/water emulsion preparation method influenced insulin performance after oral administration.	Water	104-109	LOC100508689	Homo sapiens	64-69
32159545-6	2020	Confocal microscopy and scanning electron microscopy (SEM) with energy dispersion X-ray analysis (EDAX) were used to confirm the fractal self-assembly of amylin in water and PBS buffer, respectively.	Water	164-169	islet amyloid polypeptide	Homo sapiens	154-160
32023021-0	2020	Hydrogen Peroxide Topical Solution, 40% (w/w) for the Treatment of Seborrheic Keratoses: A Review HP40 (Eskata ) is a stabilized, topical solution of 40% hydrogen peroxide (H2O2) packaged in an applicator pen that isUS FDA-approved to treat seborrheic keratoses (SKs).	Water	173-177	interleukin 9	Homo sapiens	98-102
32023021-1	2020	By harnessing the oxidative capabilities of H2O2 , 1-2 treatments with HP40 produced a higher rate of clearance of four SKs per patient compared to vehicle in two phase 3 trials.	Water	44-48	interleukin 9	Homo sapiens	71-75
31812751-9	2020	As compared with H2O2-treatment alone, the pretreatment of the cells with 100, 200 and 400 mug/mL of GA-g-CMCS significantly increased cell viability, reduced apoptosis and intracellular reactive oxygen species production, and improved membrane integrity and intracellular antioxidant enzyme (superoxide dismutase, catalase, glutathione peroxidase) activity.	Water	17-21	cerebral malaria susceptibility in CBA/N	Mus musculus	106-110
33417790-6	2019	The Sil-MA water solution with the addition of a photoinitiator (LAP) allows the opening, under UV radiation, of a double carbon-carbon bond and radical polymerization.	Water	11-16	STIL centriolar assembly protein	Homo sapiens	4-7
31940881-5	2020	Here, it was found that in vivo visfatin levels in human dental pulp tissues increase with age and are upregulated in vitro in hDPCs during premature senescence activated by H2O2, suggesting a correlation between visfatin and senescence.	Water	174-178	nicotinamide phosphoribosyltransferase	Homo sapiens	32-40
31787746-8	2019	Our data identified the KLF5 was downregulated by miR-9 overexpression and knockdown of KLF5 inhibited cardiomyocyte apoptosis induced by H2O2.	Water	138-142	Kruppel-like factor 5	Mus musculus	24-28
31787746-8	2019	Our data identified the KLF5 was downregulated by miR-9 overexpression and knockdown of KLF5 inhibited cardiomyocyte apoptosis induced by H2O2.	Water	138-142	Kruppel-like factor 5	Mus musculus	88-92
32083865-2	2020	While performing Arrhenius studies during H2 oxidation over Au/TiO2 catalysts, we found different apparent activation energies (Eapp) depending on the feed water pressure.	Water	156-161	E2F associated phosphoprotein	Homo sapiens	128-132
32083865-4	2020	Constant water coverage studies showed two kinetic regimes: fast heterolytic H2 activation directly at the MSI (Eapp ~25 kJ/mol) and significantly slower heterolytic H2 activation mediated by water (Eapp ~45 kJ/mol).	Water	192-197	E2F associated phosphoprotein	Homo sapiens	199-203
32220711-11	2020	Taken together, the author hypothesized that given appropriate concentration or dose of AQP1 agonist AqF026, the AqF026 may induce oncosis of cancer cells preferentially rather than normal cells by causing overloaded water influx via AQP1 and consequent irreversible cell swelling.	Water	217-222	aquaporin 1	Mus musculus	88-92
31735209-9	2020	Significant improvement of the detected particulate fraction in Taihu water samples was achieved by increasing the membrane pore size for pre-filtration and by using the APEX for introduction of the eluate from FFF into ICP-MS.	Water	70-75	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	170-174
31654807-5	2020	Excessive residues (>360 kg/hm2) resulted in obvious phenomenon of preferential flow, which increased the wetting distance, wetted volume, and water content in the lower part of the wetted volume and the concentration of nitrate at the boundary of the wetted volume.	Water	143-148	cholinergic receptor muscarinic 2	Homo sapiens	28-31
31645458-5	2019	SIK3 promotes the cytosolic localization of HDAC4, thereby relieving inhibition of Mef2-dependent transcription of K+ and water transport molecules.	Water	122-127	Histone deacetylase 4	Drosophila melanogaster	44-49
31903507-6	2020	With the participation of H2O2, Fe-MOF can induce the Fenton reaction which degrades MB covered by Au-rGO on the substrate.	Water	26-30	lysine acetyltransferase 8	Homo sapiens	35-38
31606532-4	2019	The hierarchical microstructure endows the GO-CTS-CS biomaterials with good tensile strength, compatible breathability, and water absorption.	Water	124-129	citrate synthase	Homo sapiens	50-52
33020707-5	2020	The binding affinity and the number of hot-spot residues, atomic contacts, and H-bond formations of the SFG/nsp16 complex were distinctly higher than those of the SAH/nsp16 system, consistent with the lower water accessibility at the enzyme active site.	Water	207-212	acyl-CoA synthetase medium chain family member 3	Homo sapiens	163-166
31621699-6	2019	Once the OSA reached the tumor site, the high level of H2O2 triggered the degradation of DPL and led to the release of Cin and Ce6.	Water	55-59	prion like protein doppel	Homo sapiens	89-92
32004873-5	2020	The nPM lacks water-insoluble PAHs (polycyclic aromatic hydrocarbons) and is depleted by >50% in bioactive metals (e.g., copper, iron, nickel), inorganic ions, black carbon, and other organic compounds.	Water	14-19	nucleophosmin 1	Homo sapiens	4-7
32106267-4	2020	Qualitative (FTIR) and quantitative (TGA) measurements confirmed the presence of trapped water within the crust.	Water	89-94	T-box transcription factor 1	Homo sapiens	37-40
31488359-9	2020	Adults collecting water is associated with increased relative risk of childhood death (RR 1.04 to 1.05), children collecting water is associated with increased odds of diarrheal disease (OR 1.10 to 1.13) and women or girls collecting water is associated with reduced uptake of antenatal care (beta-0.04 to -0.06) and increased odds of leaving a child under five alone for one or more hours, one or more days per week (OR 1.07 to 1.16).	Water	18-23	ribonucleotide reductase catalytic subunit M1	Homo sapiens	87-91
31526977-6	2019	Results show that in TS1, maize-related VW flowed from the water-scarce North to the water-rich South, with an increase of 40% over the study period (from 43 to 61 billion m3 y-1).	Water	59-64	linoleate 13S-lipoxygenase8	Zea mays	21-24
31849956-10	2019	Further, poly(I:C)-induced IFNbeta gene expression was reduced after pre-treatment with H2O2.	Water	88-92	interferon beta 1	Homo sapiens	27-34
31749326-8	2020	In addition, PPAR-gamma was up-regulated by ACART and inhibition of PPAR-gamma abolished the regulatory effects of ACART on cell apoptosis and the expression of Bcl-2, Bax and Cyt-C under H2 O2 treatment.	Water	188-193	peroxisome proliferator activated receptor gamma	Mus musculus	13-23
31849956-12	2019	Pre-treatment with H2O2 did not alter antioxidant responses in COPD bronchial epithelial cells and, more modestly than in asthma, reduced poly(I:C)-induced IFNbeta gene expression.	Water	19-23	interferon beta 1	Homo sapiens	156-163
31849956-13	2019	Knockdown of TLR3 but not RIG-I/MDA5 abrogated impairment of poly(I:C)-induced IFNbeta gene expression by H2O2.	Water	106-110	toll like receptor 3	Homo sapiens	13-17
31849956-13	2019	Knockdown of TLR3 but not RIG-I/MDA5 abrogated impairment of poly(I:C)-induced IFNbeta gene expression by H2O2.	Water	106-110	interferon beta 1	Homo sapiens	79-86
32111009-7	2020	Enzyme supplementation at 1.5 mL/L water significantly enhanced feed conversion ratio (FCR) by 4.3% during days 1-21 of age, and FCR by 5.2% and European production index (EPI) by 10.4% during days 1-35 of age compared to the group on 0.5 mL/L water.	Water	35-40	FCR	Gallus gallus	87-90
32111009-9	2020	A similar trend was observed due to intermittent multienzymes at 1 mL/L drinking water that resulted in increased BWG by (6.4%) and improved FCR by (6.7%) and EPI by (12.7%).	Water	81-86	FCR	Gallus gallus	141-144
32083427-13	2020	By contrast, serum BNP levels were significantly higher in the group with free water intake(4 studies, WMD=223.76 pg/ml ; 95% CI: 158.8 to 288.72 pg/ml; p&lt;0.001).	Water	79-84	natriuretic peptide B	Homo sapiens	19-22
31749326-8	2020	In addition, PPAR-gamma was up-regulated by ACART and inhibition of PPAR-gamma abolished the regulatory effects of ACART on cell apoptosis and the expression of Bcl-2, Bax and Cyt-C under H2 O2 treatment.	Water	188-193	peroxisome proliferator activated receptor gamma	Mus musculus	68-78
31670727-3	2019	The crystal structure was determined from powder X-ray diffraction data and the compound shows porosity towards N2 and H2O, exhibiting a BET surface area of 340 m2 g-1.	Water	119-122	delta/notch like EGF repeat containing	Homo sapiens	137-140
31730792-8	2020	CST incubation with the H2O2-challenged cardiomyocytes led to reduction of apoptosis, which was demonstrated by less Hoechst 33342 positive staining of nuclei, less caspase-3 activation, and DNA fragmentation.	Water	24-28	caspase 3	Rattus norvegicus	165-174
31646308-0	2019	Atmospheric chemistry of the self-reaction of HO2 radicals: stepwise mechanism versus one-step process in the presence of (H2O)n (n = 1-3) clusters.	Water	123-126	heme oxygenase 2	Homo sapiens	46-49
31646308-2	2019	In the present work, the HO2 + HO2 reactions with (H2O)n (n = 1-3) have been investigated using quantum chemical methods and canonical variational transition state theory with small curvature tunneling.	Water	51-54	heme oxygenase 2	Homo sapiens	25-28
31646308-2	2019	In the present work, the HO2 + HO2 reactions with (H2O)n (n = 1-3) have been investigated using quantum chemical methods and canonical variational transition state theory with small curvature tunneling.	Water	51-54	heme oxygenase 2	Homo sapiens	31-34
32110017-2	2020	However, poor water solubility and high side toxicities have severely restricted the clinical applications of CEL.	Water	14-19	carboxyl ester lipase	Mus musculus	110-113
32149243-1	2020	We report new calculations, which include the influence of the band gap and exciton states, of the electron inelastic mean free path (IMFP) for liquid water, LiF, CaF2, and Al2O3 from the band gap to 433 keV.	Water	151-156	CCR4-NOT transcription complex subunit 8	Homo sapiens	163-167
31921270-9	2019	The cpk33 mutant is impaired in H2O2-induced stomatal closure, but not in SL-mediated H2O2 production.	Water	32-36	calcium-dependent protein kinase 33	Arabidopsis thaliana	4-9
31896574-6	2020	We show that exposure to the oxidant H2O2 induced MMT1 expression, but not MMT2 expression, and identified the transcription factor Yap1 as being involved in oxidant-mediated MMT1 expression.	Water	37-41	Mmt1p	Saccharomyces cerevisiae S288C	50-54
30982748-0	2019	Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.	Water	14-19	FAT atypical cadherin 1	Homo sapiens	34-37
31706864-4	2019	Phase-solubility studies demonstrated the capability of HP-beta-CD-SH (100 mM) to form a reversible water soluble inclusion complex with BUD (SHP-beta-CD-SH = 10.9 10-3 M; K1:1 = 2013.52 M-1), which increases its permanence on the target site as proved by mucoadhesive studies on porcine oesophagus mucosa.	Water	100-105	nuclear receptor subfamily 0 group B member 2	Homo sapiens	142-145
30982748-3	2019	The aim of this study was to analyze the effects of 28-day hydrogen-rich water intake on liver fat deposition, body composition and lab chemistry profiles in overweight patients suffering from mild-to-moderate NAFLD.	Water	73-78	FAT atypical cadherin 1	Homo sapiens	95-98
31515767-7	2019	In the MAZ soil, metals were less available as shown by their low extractability rate, low capacity of metal resupply from the solid phase to pore water, and low phytoavailability.	Water	147-152	MYC associated zinc finger protein	Homo sapiens	7-10
31713255-7	2020	The reaction of NADPH in the chemical system with singlet oxygen was found to proceed in two ways, each consisting of two steps, that is, NADPH firstly reacts with 1 O2 barrierlessly to form NADP+ and HO2 - , from which H2 O2 is formed in a spontaneous reaction with H+ , or 1 O2 and H+ initially form 1 HO2 + , which further reacts with NADPH to yield NADP+ and H2 O2 .	Water	220-225	heme oxygenase 2	Homo sapiens	201-204
31713255-7	2020	The reaction of NADPH in the chemical system with singlet oxygen was found to proceed in two ways, each consisting of two steps, that is, NADPH firstly reacts with 1 O2 barrierlessly to form NADP+ and HO2 - , from which H2 O2 is formed in a spontaneous reaction with H+ , or 1 O2 and H+ initially form 1 HO2 + , which further reacts with NADPH to yield NADP+ and H2 O2 .	Water	220-225	heme oxygenase 2	Homo sapiens	304-307
31713255-7	2020	The reaction of NADPH in the chemical system with singlet oxygen was found to proceed in two ways, each consisting of two steps, that is, NADPH firstly reacts with 1 O2 barrierlessly to form NADP+ and HO2 - , from which H2 O2 is formed in a spontaneous reaction with H+ , or 1 O2 and H+ initially form 1 HO2 + , which further reacts with NADPH to yield NADP+ and H2 O2 .	Water	363-368	heme oxygenase 2	Homo sapiens	201-204
31713255-7	2020	The reaction of NADPH in the chemical system with singlet oxygen was found to proceed in two ways, each consisting of two steps, that is, NADPH firstly reacts with 1 O2 barrierlessly to form NADP+ and HO2 - , from which H2 O2 is formed in a spontaneous reaction with H+ , or 1 O2 and H+ initially form 1 HO2 + , which further reacts with NADPH to yield NADP+ and H2 O2 .	Water	363-368	heme oxygenase 2	Homo sapiens	304-307
31288169-0	2019	A water-soluble molecular probe with aggregation-induced emission for discriminative detection of Al3+ and Pb2+ and imaging in seedling root of Arabidopsis.	Water	2-7	alfin-like 3	Arabidopsis thaliana	98-101
31612523-10	2020	Mechanism analysis indicated that morphine alleviated serum deprivation and H2 O2 -induced angiogenesis inhibition via reducing oxidative stress and damage, and activating Akt/mTOR/eIF4E signaling.	Water	76-81	eukaryotic translation initiation factor 4E	Homo sapiens	181-186
31415124-10	2019	In addition, the Emx1-Lgl1-/- mice displayed impaired behavioral performance in the Morris water maze and fear conditioning test.	Water	91-96	empty spiracles homeobox 1	Mus musculus	17-21
33324137-3	2019	In this paper, we show the reconstructed simultaneous impacts of Hurricane Bob on the vegetative cover of the Mattapoisett river watershed and the water quality of the Mattapoisett Harbor with the aid of remote sensing for earth observations.	Water	129-134	G protein-coupled receptor 15	Homo sapiens	75-78
31550675-7	2019	SCAMP1 depletion attenuated cell viability and promoted apoptosis under H2O2 treatment.	Water	72-76	secretory carrier membrane protein 1	Homo sapiens	0-6
31671815-1	2019	Recent studies showed that KGN cells, derived from a human granulosa cell tumor (GCT), express NADPH oxidase 4 (NOX4), an important source of H2O2.	Water	142-146	NADPH oxidase 4	Homo sapiens	95-110
31671815-1	2019	Recent studies showed that KGN cells, derived from a human granulosa cell tumor (GCT), express NADPH oxidase 4 (NOX4), an important source of H2O2.	Water	142-146	NADPH oxidase 4	Homo sapiens	112-116
31907700-0	2020	Silencing of soluble epoxide hydrolase 2 gene reduces H2O2-induced oxidative damage in rat intestinal epithelial IEC-6 cells via activating PI3K/Akt/GSK3beta signaling pathway.	Water	54-58	glycogen synthase kinase 3 beta	Rattus norvegicus	149-157
31907700-12	2020	We proved that siEPHX2 had a protective effect on H2O2-induced oxidative damage in IEC-6 cells through activating PI3K/Akt/GSK3beta signaling pathway.	Water	50-54	glycogen synthase kinase 3 beta	Rattus norvegicus	123-131
31845242-2	2020	This study reported eco-friendly and reusable EPS/Fe3O4 was applied in the sulfonamide-contaminated water treatment, including sulfamethoxazole (SMX), sulfamerazine (SM1), sulfamethazine (SM2) and sulfadiazine (SDZ), respectively.	Water	100-105	SM2	Homo sapiens	188-191
31708788-12	2019	Moreover, BIBO3304 and FoxO4 siRNA significantly increased the cell activity, inhibited the cell apoptosis, and decreased caspase-3 expression and activity in H2O2-treated cardiomyocytes that NPY presented the opposite effect.	Water	159-163	forkhead box O4	Rattus norvegicus	23-28
31550675-8	2019	Then, miR-429 was identified as downstream effector for SCAMP1-mediated tumorigenesis under H2O2 treatment.	Water	92-96	secretory carrier membrane protein 1	Homo sapiens	56-62
31708788-12	2019	Moreover, BIBO3304 and FoxO4 siRNA significantly increased the cell activity, inhibited the cell apoptosis, and decreased caspase-3 expression and activity in H2O2-treated cardiomyocytes that NPY presented the opposite effect.	Water	159-163	caspase 3	Rattus norvegicus	122-131
31585206-7	2019	Further studies showed that H2O2 regulated biological rhythm by PRX2-STAT3-REV-ERBalpha/beta pathway.	Water	28-32	paired related homeobox 2	Mus musculus	64-68
31513396-5	2019	In the presence of PF6- ions that are derived from hydrofluoric acid, a macrocyclic uranyl-phosphonate discrete compound, 1, whose cavity contains PF6- ions, hydronium ions, and water molecules, is obtained.	Water	178-183	sperm associated antigen 17	Homo sapiens	19-22
31830634-6	2020	The results achieved in this study would lay a foundation for future development of selective, potent, low-toxic and water-soluble CYP1B1 inhibitors.	Water	117-122	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	131-137
31776182-7	2020	These results indicate that the chloroplast protein PPD5 negatively regulates drought resistance by modulating guard cell H2O2 accumulation via an OST1-dependent pathway.	Water	122-126	ribophorin I	Homo sapiens	147-151
31776182-9	2020	These results indicate that both OST1-dependent and OST1-independent pathways exist in the regulation of H2O2 production in chloroplasts of guard cells under drought stress conditions.	Water	105-109	ribophorin I	Homo sapiens	33-37
31776182-9	2020	These results indicate that both OST1-dependent and OST1-independent pathways exist in the regulation of H2O2 production in chloroplasts of guard cells under drought stress conditions.	Water	105-109	ribophorin I	Homo sapiens	52-56
31776360-4	2019	The mechanism involves signaling by mitochondria-generated H2O2 (mH2O2) acting via the redox sensor, peroxiredoxin-1, a thiol peroxidase with high reactivity towards H2O2 that activates c-Jun N-terminal kinase-2alpha2 (JNK2alpha2).	Water	59-63	jun proto-oncogene	Mus musculus	186-191
31632242-11	2019	Additionally, we also show that H2O2 (100 muM) produces a robust increase in Ca2+ entry in cell cultures which is enhanced by TNF-alpha via the TRPV1 channel and which involves ERK1/2 phosphorylation.	Water	32-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	144-149
31632242-11	2019	Additionally, we also show that H2O2 (100 muM) produces a robust increase in Ca2+ entry in cell cultures which is enhanced by TNF-alpha via the TRPV1 channel and which involves ERK1/2 phosphorylation.	Water	32-36	mitogen activated protein kinase 3	Rattus norvegicus	177-183
31854429-1	2020	A novel approach for the detection and separation of toxic ions was successfully developed via the introduction of competitive reactions into a long-alkyl-chained acylhydrazone-based coumarin supramolecular polymer, chemosensor OGC (3%, n-BuOH/H2O), which showed sequential detection and separation of CN-, Fe3+ and S2-, Ag+ in the gel state with high selectivity and sensitivity.	Water	244-247	solute carrier family 25 member 11	Homo sapiens	228-231
31776360-4	2019	The mechanism involves signaling by mitochondria-generated H2O2 (mH2O2) acting via the redox sensor, peroxiredoxin-1, a thiol peroxidase with high reactivity towards H2O2 that activates c-Jun N-terminal kinase-2alpha2 (JNK2alpha2).	Water	66-70	jun proto-oncogene	Mus musculus	186-191
31776360-4	2019	The mechanism involves signaling by mitochondria-generated H2O2 (mH2O2) acting via the redox sensor, peroxiredoxin-1, a thiol peroxidase with high reactivity towards H2O2 that activates c-Jun N-terminal kinase-2alpha2 (JNK2alpha2).	Water	66-70	jun proto-oncogene	Mus musculus	186-191
31505255-6	2019	This study also indicates the important role of CXCR7 molecule in maintaining CNS homeostasis by balancing M1/M2 microglia, A1/A2 astrocytes, long term potentiation/long term depression markers which ultimately ameliorates HMGB1 induced neurodegeneration, synaptic depression and memory loss (assessed by both radial arm maze and Morris water maze) in male mice model of dementia.	Water	337-342	high mobility group box 1	Mus musculus	223-228
31992828-7	2020	H2O2-induced intracellular ROS and apoptosis in endothelial cells and fibroblasts were suppressed by apelin in vitro.	Water	0-4	apelin	Mus musculus	101-107
31922647-2	2020	A preliminary survey of their reactivity includes ring reduction of Li(THF)4 [PcUCl3 ] with KC8 leading to the first structurally characterized Pc4- actinide complex, hydrolysis of PcDyCl(DMSO) to PcDyOH(H2 O)3 and preparation of a unique trimeric triangular Li(PcDy)3 (OH)4 (H2 O) cluster.	Water	204-208	proprotein convertase subtilisin/kexin type 4	Homo sapiens	144-147
31845953-1	2020	Reactions of CuX with the bis(triazolyl) ligand Hbtm [bis(1-benzyl-1H-1,2,3-triazol-4-yl)phenylmethanol] in CH2Cl2 afforded trinuclear copper(ii) complexes with a core structure (mu-X)Cu3(mu-kappa3-N,O,N-btm)3(L)2+ [X = Cl, L = CH3OH (1); X = Br, L = H2O (2)], while a similar reaction of [Cu(CH3CN)4](PF6) with the mono(triazolyl) ligand HPhtm [(1-benzyl-1H-1,2,3-triazol-4-yl)diphenylmethanol] resulted in the mononuclear complex [Cu(kappa2-N,O-Phtm)(kappa2-N,O-HPhtm)(kappa1-N-HPhtm)][PF6] (3).	Water	251-258	cut like homeobox 1	Homo sapiens	13-16
31063681-2	2019	In the aquaporin (AQP) water channel family, AQP1 and AQP4 play critical roles in the progress of cerebral oedema of various neuropathological events.	Water	23-28	aquaporin 1	Rattus norvegicus	45-49
31100203-7	2019	As the mechanism of indirect effect, H2 in drinking water induces ghrelin production and release from the stomach via beta1-adrenergic receptor stimulation.	Water	52-57	ghrelin	Mus musculus	66-73
31422192-1	2019	In this work, a water-soluble okra polysaccharide (OP-2) was prepared by hot water extraction, and the effects of OP-2 on the spermatogenesis of KKAy mice were investigated.	Water	16-21	bone morphogenetic protein 8a	Mus musculus	51-55
31357126-8	2019	Therefore, PEZ-alt-PEG polymeric micelles, with their high thermodynamic stability, high drug-loading capacity, enhanced drug uptake and improved pharmacodynamic effects, could serve as efficient and promising nanocarriers for poorly water-soluble drugs.	Water	234-239	protein tyrosine phosphatase non-receptor type 14	Homo sapiens	11-14
31660977-10	2019	Treatment with NDP-MSH remarkably improved neurological function and reduced BBB disruption, brain water content, and the number of microglia in the peri-hematoma tissue after ICH.	Water	99-104	Norrie disease (pseudoglioma) (human)	Mus musculus	15-18
31286686-4	2019	The average dmdA:recA gene ratio over the sampling period was 0.40 +- 0.24 in marine snow and 0.48 +- 0.21 in the ambient water.	Water	122-127	sarcoglycan gamma	Homo sapiens	12-16
31822063-0	2020	pH-Neutralization, Redox-Balanced Process with Coupled Formate Dehydrogenase and Glucose Dehydrogenase Supports Efficient Xylitol Production in Pure Water.	Water	149-154	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	81-102
31440975-6	2019	The developed model is then applied to forecast the surface water quality variations for real-time early warning in Ashi River, China, comparing with simple BPNN model.	Water	60-65	NADH:ubiquinone oxidoreductase subunit B8	Homo sapiens	116-120
31708788-9	2019	Moreover, NPY type 1 receptor antagonist BIBO3304 can reverse miR-499 decrease and FoxO4 increase in H2O2-induced cardiomyocytes.	Water	101-105	forkhead box O4	Rattus norvegicus	83-88
32021088-1	2020	Purpose: Our previous studies have indicated that non-muscle myosin heavy chain IIA (NMMHC IIA) is involved in H2O2-induced neuronal apoptosis, which is associated with the positive feedback loop of caspase-3/ROCK1/MLC pathway.	Water	111-115	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	209-214
31708788-10	2019	NPY siRNA inhibited cell apoptosis in H2O2-treated H9c2 cells that were reversed by miR-499 inhibitor.	Water	38-42	microRNA 499a	Rattus norvegicus	84-91
31527118-10	2019	Here we identified that the water accessibility around transmembrane domain 3 in presenilin 1 was increased along with a reduction in toxic amyloid-beta production.	Water	28-33	presenilin 1	Homo sapiens	81-93
31474480-0	2020	Cool Running Water First Aid Decreases Skin Grafting Requirements in Pediatric Burns: A Cohort Study of Two Thousand Four Hundred Ninety-five Children.	Water	13-18	activation induced cytidine deaminase	Homo sapiens	25-28
31241990-10	2019	Fibroblast growth factor 21, an endocrine regulator of sweetness preference, was significantly higher in female CDNOS1KO mice, suggesting that this was reducing their drive to drink the sucrose water.	Water	194-199	fibroblast growth factor 21	Mus musculus	0-27
31624912-0	2019	Assessment of spa mineral water quality from Vrnjacka Banja, Serbia: geochemical, bacteriological, and health risk aspects.	Water	26-31	surfactant protein A1	Homo sapiens	14-17
31228813-2	2019	The objective of the present study is to explore the role of miR-21-5p in EAU.	Water	74-77	microRNA 21a	Mus musculus	61-67
32219956-2	2020	TJs in intestinal epithelial cells are composed of different junctional molecules, such as claudin and occludin, and regulate the paracellular permeability of water, ions, and macromolecules in adjacent cells.	Water	159-164	occludin	Homo sapiens	103-111
31408344-4	2019	9-Methylguanine (9-meG) in complex with six water molecules (9-meG 6H2O) is found out to be the most accurate one for describing GMP in two different bright electronic states.	Water	44-49	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	19-22
32811404-5	2020	Moreover, the hydrophobic subunits of daidzin, in a conformationally more restricted environment (such as the cata-lytic site of ALDH-2), promote the better organization of the water molecules when immersed in the solvent, also resulting in an entropic gain.	Water	177-182	aldehyde dehydrogenase 2 family member	Homo sapiens	129-135
31480555-0	2019	Confined Dynamics of Water in Transmembrane Pore of TRPV1 Ion Channel.	Water	21-26	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
31480555-5	2019	In this work, the results of molecular dynamics (MD) simulations of water in the pore and selectivity filter domains of TRPV1 (Transient Receptor Potential Vanilloid type 1) membrane channel are considered.	Water	68-73	transient receptor potential cation channel subfamily V member 1	Homo sapiens	120-125
31480555-5	2019	In this work, the results of molecular dynamics (MD) simulations of water in the pore and selectivity filter domains of TRPV1 (Transient Receptor Potential Vanilloid type 1) membrane channel are considered.	Water	68-73	transient receptor potential cation channel subfamily V member 1	Homo sapiens	127-172
31480555-9	2019	Presumably, these water "blobs" play an important role in the functional activity of TRPV1.	Water	18-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	85-90
31480555-10	2019	In particular, they take part in hydration of the hydrophobic TRPV1 pore by localizing up to six waters near the so-called "lower gate" of the channel and reducing by this way the free energy barrier for ion and water transport.	Water	97-102	transient receptor potential cation channel subfamily V member 1	Homo sapiens	62-67
31408344-4	2019	9-Methylguanine (9-meG) in complex with six water molecules (9-meG 6H2O) is found out to be the most accurate one for describing GMP in two different bright electronic states.	Water	44-49	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	63-66
31576861-1	2019	A new flexible triazine-based polycarboxylate coordination polymer, {[Co3(H3TTHA)2(4,4"-bipy)5(H2O)8] 12H2O}n (1), where H6TTHA = 1,3,5-triazine-2,4,6-triamine hexaacetic acid, has been synthesized under hydrothermal conditions and structurally characterized by infrared spectroscopy, elemental analysis, TGA, XRD and X-ray single-crystal diffraction.	Water	68-109	T-box transcription factor 1	Homo sapiens	305-308
31274304-3	2019	The parameters allowed exchange of the water molecules coordinating the zinc ion and proved to be robust enough to enable reliable modeling not only of human DPP III and its orthologues but also of the other zinc-dependent peptidases with the zinc ion coordination similar to that in dipeptidyl peptidases III, i.e., peptidases with the zinc ion coordinated with two histidines and one glutamate.	Water	39-44	dipeptidyl peptidase 3	Homo sapiens	158-165
31305832-3	2019	The MOF was applied as an efficient bifunctional hydrogen-bonding catalyst for Michael additions of 1,3-dicarbonyl compounds to nitroalkenes in pure water, boosting the catalytic efficiency by up to approximately five times the value afforded by the homogeneous control and exhibiting a highly size-selective catalytic performance and good renewability.	Water	149-154	lysine acetyltransferase 8	Homo sapiens	4-7
31578149-7	2019	The regenerated fibroin hydrogels with good water uptake properties rapidly swelled to a 17.3-fold maximum swelling behavior over 12 h and a total amount of 40.48 +- 1.28% hydrogels was lost within 15 days.	Water	44-49	fibroin light chain	Bombyx mori	16-23
31503597-7	2019	The errors of the sensor data records (SDR or Level-1B radiance) due to the polarization effect can be as large as ~1% for bands M1 and M2, and those in the ocean normalized water-leaving radiances are about 13% and 10% for wavelengths at 411 nm (band M1) and 445 nm (band M2), respectively.	Water	174-179	caveolae associated protein 2	Homo sapiens	39-42
31355977-6	2019	Furthermore, the facile chemical transformation of Ag3 PO4 in the composite scaffold into Ag2 S provided an analogous unidirectional composite silk scaffold that displays both efficient solar water evaporation effect and antibacterial activity.	Water	192-197	angiotensin II receptor type 1	Homo sapiens	90-95
31359624-3	2019	Relative to the parent PSMs, peptide zp3 (GIIAGIIIKIKK-NH2 ) was found to possess greatly improved physicochemical properties (soluble in water) and antibacterial activity (MIC=8 mum for E. coli, B. subtilis, and C. freundii) while maintaining low hemolytic activity (<5 % at 256 mum) and cytotoxicity (HEK293 cells IC50 >80 mum).	Water	138-143	zona pellucida glycoprotein 3	Homo sapiens	37-40
31226241-4	2019	Passive remediation is one method used to naturally allow the metals to precipitate out and aid in cleaning up the water.	Water	115-120	activation induced cytidine deaminase	Homo sapiens	92-95
31365247-6	2019	Powder second harmonic generation measurements disclosed that In3(SO4)(TeO3)2F3(H2O) exhibits a weak frequency-doubling efficiency about 11% of the commercial KDP.	Water	80-83	WNK lysine deficient protein kinase 1	Homo sapiens	159-162
31393117-5	2019	This LHRH-platinum(IV) conjugate is highly soluble in water and quite stable in a PBS buffer.	Water	54-59	gonadotropin releasing hormone 1	Homo sapiens	5-9
31412646-4	2019	Prior to hydrolysis, 3F and nPM are insoluble in water and form a lens at the bottom (3F) or top (nPM) of the solutions.	Water	49-54	nucleophosmin 1	Homo sapiens	28-31
31061242-4	2019	In the present study, the SRS interferometer developed by the authors is applied to distinguish whether water or air is present in the trenches on the water-substrate interface buried by water.	Water	104-109	Russell-Silver dwarfism	Homo sapiens	26-29
31061242-4	2019	In the present study, the SRS interferometer developed by the authors is applied to distinguish whether water or air is present in the trenches on the water-substrate interface buried by water.	Water	151-156	Russell-Silver dwarfism	Homo sapiens	26-29
31061242-4	2019	In the present study, the SRS interferometer developed by the authors is applied to distinguish whether water or air is present in the trenches on the water-substrate interface buried by water.	Water	151-156	Russell-Silver dwarfism	Homo sapiens	26-29
31061242-5	2019	By obtaining the SRS interference signal generated from water while scanning the sample position, the phase shift of the SRS interference signal due to the microstructure on the interface was observed.	Water	56-61	Russell-Silver dwarfism	Homo sapiens	17-20
31061242-5	2019	By obtaining the SRS interference signal generated from water while scanning the sample position, the phase shift of the SRS interference signal due to the microstructure on the interface was observed.	Water	56-61	Russell-Silver dwarfism	Homo sapiens	121-124
31141395-1	2019	Arginine-vasopressin (AVP)-mediated translocation of aquaporin-2 (AQP2) protein-forming water channels from storage vesicles to the membrane of renal collecting ducts is critical for the renal conservation of water.	Water	88-93	aquaporin 2	Sus scrofa	53-64
31141395-1	2019	Arginine-vasopressin (AVP)-mediated translocation of aquaporin-2 (AQP2) protein-forming water channels from storage vesicles to the membrane of renal collecting ducts is critical for the renal conservation of water.	Water	88-93	aquaporin 2	Sus scrofa	66-70
31141395-1	2019	Arginine-vasopressin (AVP)-mediated translocation of aquaporin-2 (AQP2) protein-forming water channels from storage vesicles to the membrane of renal collecting ducts is critical for the renal conservation of water.	Water	209-214	aquaporin 2	Sus scrofa	53-64
31141395-1	2019	Arginine-vasopressin (AVP)-mediated translocation of aquaporin-2 (AQP2) protein-forming water channels from storage vesicles to the membrane of renal collecting ducts is critical for the renal conservation of water.	Water	209-214	aquaporin 2	Sus scrofa	66-70
31103825-3	2019	In this study we investigated the effect of Haematococcus pluvialis algae water extract enriched in bioaccumulation process in magnesium ions (Hp_Mg(II)) on equine adipose derived mesenchymal stromal stem cells, in which insulin resistance was induced by palmitic acid (IR-EqASCs).	Water	74-79	INS	Equus caballus	221-228
30999038-5	2019	The water-soluble pristine C60 fullerene at the concentration of 20 mug/ml and 40 mug/ml leads to the activation of the mus209 gene in D. melanogaster larvae salivary glands, which can indicate higher levels of DNA damage.	Water	4-9	Proliferating cell nuclear antigen	Drosophila melanogaster	120-126
31359137-2	2019	In this study, soil column experiments were conducted to assess the rate of salt removal and estimate the amount of water required for leaching in order to reduce salinity (EC) to &lt;= 4 dS m-1 and sodicity (ESP) to &lt; 10.	Water	116-121	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	209-212
31357724-2	2019	In this study, smooth 2D amorphous tin disulfide (SnS2) films were fabricated by atomic layer deposition (ALD), and applied for the first time to photoelectrochemical water splitting.	Water	167-172	sodium voltage-gated channel alpha subunit 11	Homo sapiens	50-54
31396333-8	2019	This mechanism induces an interaction with sirtuin 1 (SIRT1)/p53 pathway suggesting a link between ghrelin and SIRT1 in the regulation of salt and water metabolism.	Water	147-152	ghrelin	Mus musculus	99-106
31396333-12	2019	Water movement across biological cell membranes is enhanced or facilitated by tetrameric membrane-bound channels, named aquaporin (AQP) family, and in particular, AQP1 and AQP2 proteins.	Water	0-5	aquaporin 1	Mus musculus	163-167
31257867-7	2019	Computationally modeled structures of LnX3 show a systematic increase in the lanthanide-2 coordination number (CNLa-mc = 2 (NO3-), 4 (Cl-), 5 (H2O, model for OTf-)) and a decrease in the mean Ln-N bond length (La-Naverage = 2.91 A (NO3-), 2.78 A (Cl-), 2.68 A (H2O)), further suggesting that a decrease in the anion coordination number correlates with an increase in the metal-macrocycle interaction.	Water	143-146	PDZ domain containing ring finger 3	Homo sapiens	38-42
31257867-7	2019	Computationally modeled structures of LnX3 show a systematic increase in the lanthanide-2 coordination number (CNLa-mc = 2 (NO3-), 4 (Cl-), 5 (H2O, model for OTf-)) and a decrease in the mean Ln-N bond length (La-Naverage = 2.91 A (NO3-), 2.78 A (Cl-), 2.68 A (H2O)), further suggesting that a decrease in the anion coordination number correlates with an increase in the metal-macrocycle interaction.	Water	261-264	PDZ domain containing ring finger 3	Homo sapiens	38-42
32402638-1	2020	The mineralocorticoid receptor (MR) has classically been studied in the renal epithelium for its role in regulating sodium and water balance and, subsequently, blood pressure.	Water	127-132	nuclear receptor subfamily 3 group C member 2	Homo sapiens	4-30
32402638-1	2020	The mineralocorticoid receptor (MR) has classically been studied in the renal epithelium for its role in regulating sodium and water balance and, subsequently, blood pressure.	Water	127-132	nuclear receptor subfamily 3 group C member 2	Homo sapiens	32-34
31746362-9	2020	Additionally, H2O2 induced an upregulation of HDAC2 in NRK-52E cells, while NaBu inhibited this process.	Water	14-18	histone deacetylase 2	Rattus norvegicus	46-51
31897224-12	2020	The results from generalized multifactor dimensionality reduction (GMDR) model showed that there was interaction effect with abnormities of vagina cleanness, H2O2, beta-glucuronidase and neuraminidase on CIN2/3 in HPV16 negative group, while, there was interaction effect with abnormities of vagina cleanness, beta-glucuronidase and neuraminidase on CIN1 and with abnormities of vagina cleanness, PH, H2O2, beta-glucuronidase, neuraminidase and leukocyte esterase on CIN2/3 in HPV16 positive group.	Water	401-405	neuraminidase 1	Homo sapiens	187-200
31869409-9	2020	Treatment with H2O2 increased apoptosis and the activity of the pro-apoptotic factors caspase-8 and caspase-3, both of which were attenuated by TUDCA.	Water	15-19	caspase 8	Homo sapiens	86-95
31902877-6	2020	Hypoxia enhanced H2O2-induced TRPA1 responses in human TRPA1-expressing cells and cultured mouse dorsal root ganglion neurons, with this hypoxia-induced TRPA1 sensitization to H2O2 being associated with hypoxia-induced inhibition of the hydroxylation of prolyl hydroxylases.	Water	17-21	transient receptor potential cation channel subfamily A member 1	Homo sapiens	30-35
31261295-11	2019	CONCLUSIONS: Chronic, advanced stage IgAN is associated with renal softening and restricted water diffusion.	Water	92-97	IGAN1	Homo sapiens	37-41
31902877-6	2020	Hypoxia enhanced H2O2-induced TRPA1 responses in human TRPA1-expressing cells and cultured mouse dorsal root ganglion neurons, with this hypoxia-induced TRPA1 sensitization to H2O2 being associated with hypoxia-induced inhibition of the hydroxylation of prolyl hydroxylases.	Water	17-21	transient receptor potential cation channel subfamily A member 1	Homo sapiens	55-60
31902877-6	2020	Hypoxia enhanced H2O2-induced TRPA1 responses in human TRPA1-expressing cells and cultured mouse dorsal root ganglion neurons, with this hypoxia-induced TRPA1 sensitization to H2O2 being associated with hypoxia-induced inhibition of the hydroxylation of prolyl hydroxylases.	Water	176-180	transient receptor potential cation channel subfamily A member 1	Homo sapiens	30-35
31902877-6	2020	Hypoxia enhanced H2O2-induced TRPA1 responses in human TRPA1-expressing cells and cultured mouse dorsal root ganglion neurons, with this hypoxia-induced TRPA1 sensitization to H2O2 being associated with hypoxia-induced inhibition of the hydroxylation of prolyl hydroxylases.	Water	176-180	transient receptor potential cation channel subfamily A member 1	Homo sapiens	55-60
31755338-7	2019	As a result, treatment of mice with 10% high glucose enriched water increased secretion of insulin/IGF1 and reduced A20 protein level, the effects were blunted in Akt2-/- mice.	Water	62-67	insulin-like growth factor 1	Mus musculus	99-103
31957390-7	2020	As the optimal treatments found by the model, we obtained the suitable water-fertilizer application range of shallow-buried drip irrigation with higher target yield of 8000-8810 kg hm-2, that was, the irrigation amount was 43-61 mm, nitrogen 138-343 kg hm-2 and potassium 79-163 kg hm-2 under the ambient natural rainfall.	Water	71-76	Putative anthocyanidin reductase	Zea mays	181-185
31957390-7	2020	As the optimal treatments found by the model, we obtained the suitable water-fertilizer application range of shallow-buried drip irrigation with higher target yield of 8000-8810 kg hm-2, that was, the irrigation amount was 43-61 mm, nitrogen 138-343 kg hm-2 and potassium 79-163 kg hm-2 under the ambient natural rainfall.	Water	71-76	Putative anthocyanidin reductase	Zea mays	253-257
31957390-7	2020	As the optimal treatments found by the model, we obtained the suitable water-fertilizer application range of shallow-buried drip irrigation with higher target yield of 8000-8810 kg hm-2, that was, the irrigation amount was 43-61 mm, nitrogen 138-343 kg hm-2 and potassium 79-163 kg hm-2 under the ambient natural rainfall.	Water	71-76	Putative anthocyanidin reductase	Zea mays	253-257
31755338-7	2019	As a result, treatment of mice with 10% high glucose enriched water increased secretion of insulin/IGF1 and reduced A20 protein level, the effects were blunted in Akt2-/- mice.	Water	62-67	tumor necrosis factor, alpha-induced protein 3	Mus musculus	116-119
31349414-9	2019	Films" wettability was enhanced by the presence of CS as shown by the decrease of water contact angle.	Water	82-87	citrate synthase	Homo sapiens	51-53
31789022-0	2019	AAAA-DDDD Quadruple H-Bond-Assisted Ionic Interactions: Robust Bis(guanidinium)/Dicarboxylate Heteroduplexes in Water.	Water	112-117	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	5-9
31533957-6	2019	Structural comparison of the monomer and dimer revealed that a hydrogen bond network of water molecules is formed at the entry surface of the proton transfer pathway, termed the K-pathway, in monomeric CcO, whereas this network is altered in dimeric CcO.	Water	88-93	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	202-205
31742379-4	2019	Here, a hierarchically assembled GO composite membrane was developed that can achieve high-efficiency water purification performance and self-healing property via the synergistic effect of the metal-organic framework (MOF) and the coated hydrophilic layer of chitosan.	Water	102-107	lysine acetyltransferase 8	Homo sapiens	193-222
31657199-4	2019	Herein, we constructed a novel probe: H2O2 responding fluorophore donor was linked by MMP2-sensitive peptides tagged a FRET Cy5 acceptor.	Water	38-42	matrix metallopeptidase 2	Homo sapiens	86-90
31657199-7	2019	The stimulation with H2O2 made probe-loaded living cells emit multicolor fluorescence: mainly red fluorescence in normal RAW264.7 cells and poorly-invasive MCF7 cells; only green fluorescence in highly-invasive MDA-MA-231 cells, owing to different expression of MMP2.	Water	21-25	matrix metallopeptidase 2	Homo sapiens	262-266
31533957-6	2019	Structural comparison of the monomer and dimer revealed that a hydrogen bond network of water molecules is formed at the entry surface of the proton transfer pathway, termed the K-pathway, in monomeric CcO, whereas this network is altered in dimeric CcO.	Water	88-93	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	250-253
31576091-12	2019	After treatment with Sirt1-siRNA or Sirt1 inhibitor (EX527), the hyperacetylated HMGB1 in hepatocytes increased, and Sirt1 activity inhibited by H2O2 could be reversed by Parp1 inhibitor (DIQ).	Water	145-149	high mobility group box 1	Mus musculus	81-86
31398611-8	2019	Considering the high adsorption properties, good water stability, especially easy separation, and excellent recyclability, Al-MOF/SA-CS composite beads could be a promising adsorbent for the removal of BPA from contaminated water.	Water	224-229	lysine acetyltransferase 8	Homo sapiens	126-129
31555995-8	2019	Our results suggest that the P. stutzeri species-specific ncRNA NfiS acts as a regulator that integrates adaptation to H2O2 with other cellular stress responses and helps protect E. coli cells against oxidative damage.	Water	119-123	ffs	Pseudomonas stutzeri	58-63
31468975-4	2019	This is due to differences in contact angle being up to 40  when comparing results from pL- and muL-sized water-based droplets.	Water	106-111	tripartite motif containing 37	Homo sapiens	96-99
31601978-5	2019	Consequently, two cytokinin downstream type-A response regulators, ARR16 and ARR17, were found to be up-regulated at the lower water potential side, causing increased cell division in the meristem zone, which allows the root to bend towards higher water potential side.	Water	127-132	response regulator 17	Arabidopsis thaliana	77-82
31601978-5	2019	Consequently, two cytokinin downstream type-A response regulators, ARR16 and ARR17, were found to be up-regulated at the lower water potential side, causing increased cell division in the meristem zone, which allows the root to bend towards higher water potential side.	Water	248-253	response regulator 17	Arabidopsis thaliana	77-82
31460527-2	2019	The in situ encapsulation of a dye into the MOF matrix can expressly tune the phosphorescence color from green to a rare example of red emission with a lifetime of 450 ms, highly enhancing the photoelectrocatalytic water splitting.	Water	215-220	lysine acetyltransferase 8	Homo sapiens	44-47
31522024-3	2019	As a result, the CBD conjugated Lipase-A (LipA-CBD) demonstrated a multi-layer self-assemble on cotton fabric surface and enhanced hydrophobicity as detected by both scanning electron microscope and water contact angle measurement.	Water	199-204	lipase A, lysosomal acid type	Homo sapiens	42-46
31585206-6	2019	In addition, H2O2 modulated the circadian rhythm of Bmal1-luciferase via RORalpha, REV-ERBalpha (NR1D1), and REV-ERBbeta (NR1D2).	Water	13-17	nuclear receptor subfamily 1, group D, member 2	Mus musculus	109-120
31585206-6	2019	In addition, H2O2 modulated the circadian rhythm of Bmal1-luciferase via RORalpha, REV-ERBalpha (NR1D1), and REV-ERBbeta (NR1D2).	Water	13-17	nuclear receptor subfamily 1, group D, member 2	Mus musculus	122-127
31408307-0	2019	Influence of Water on Structure, Dynamics, and Electrostatics of Hydrophilic and Hydrophobic Ionic Liquids in Charged and Hydrophilic Confinement between Mica Surfaces.	Water	13-18	MHC class I polypeptide-related sequence A	Homo sapiens	154-158
31638263-9	2019	We found that ectopic expression of miR-455 protected cells from damage caused by H2O2.	Water	82-86	microRNA 455	Homo sapiens	36-43
31511569-2	2019	In this study, gas chromatography coupled with mass spectrometry (GC-MS) was employed for the determination of signatures found in ER+/PR+ breast cancer cells derived from MCF-7 using different extraction solvents including: A, formic acid in water; B, ammonium hydroxide in water; C, ethyl acetate; D, methanol: water (1:1, v/v); and E, acetonitrile: water (1:1, v/v).	Water	243-248	epiregulin	Homo sapiens	131-133
31728857-8	2019	Further experiments verified that PF pretreatment alleviated H2O2-induced oxidative stress through increasing cell viability, inhibiting cell apoptosis, reducing ROS generation and activating JAK2/STAT3 and ERK1/2 pathways.	Water	61-65	mitogen-activated protein kinase 3	Mus musculus	207-213
31511569-2	2019	In this study, gas chromatography coupled with mass spectrometry (GC-MS) was employed for the determination of signatures found in ER+/PR+ breast cancer cells derived from MCF-7 using different extraction solvents including: A, formic acid in water; B, ammonium hydroxide in water; C, ethyl acetate; D, methanol: water (1:1, v/v); and E, acetonitrile: water (1:1, v/v).	Water	275-280	epiregulin	Homo sapiens	131-133
31728857-11	2019	These results indicated that PF can alleviate H2O2-induced oxidative stress by down-regulation of miR-135a via activation of JAK2/STAT3 and ERK1/2 pathways.	Water	46-50	mitogen-activated protein kinase 3	Mus musculus	140-146
31305545-4	2019	The excess electrons induce a strong electrostatic field, leading to the transformation from water to an ice-VIII structure.	Water	93-98	cytochrome c oxidase subunit 8A	Homo sapiens	109-113
31511569-2	2019	In this study, gas chromatography coupled with mass spectrometry (GC-MS) was employed for the determination of signatures found in ER+/PR+ breast cancer cells derived from MCF-7 using different extraction solvents including: A, formic acid in water; B, ammonium hydroxide in water; C, ethyl acetate; D, methanol: water (1:1, v/v); and E, acetonitrile: water (1:1, v/v).	Water	275-280	epiregulin	Homo sapiens	131-133
31511569-2	2019	In this study, gas chromatography coupled with mass spectrometry (GC-MS) was employed for the determination of signatures found in ER+/PR+ breast cancer cells derived from MCF-7 using different extraction solvents including: A, formic acid in water; B, ammonium hydroxide in water; C, ethyl acetate; D, methanol: water (1:1, v/v); and E, acetonitrile: water (1:1, v/v).	Water	275-280	epiregulin	Homo sapiens	131-133
31506286-5	2019	Superoxide dismutase 2 (SOD2) is a mitochondrial-specific antioxidant enzyme that dismutates superoxide to hydrogen peroxide, which is then converted to water by catalase and glutathione peroxidase.	Water	153-158	superoxide dismutase 2	Homo sapiens	0-22
30991320-0	2019	Sustainable synthesis and remarkable adsorption capacity of MOF/graphene oxide and MOF/CNT based hybrid nanocomposites for the removal of Bisphenol A from water.	Water	155-160	lysine acetyltransferase 8	Homo sapiens	60-63
30991320-0	2019	Sustainable synthesis and remarkable adsorption capacity of MOF/graphene oxide and MOF/CNT based hybrid nanocomposites for the removal of Bisphenol A from water.	Water	155-160	lysine acetyltransferase 8	Homo sapiens	83-86
30508150-0	2019	A SIMPLIFIED METHOD FOR THE WATER-EQUIVALENT DIAMETER CALCULATION TO ESTIMATE PATIENT DOSE IN CT EXAMINATIONS.	Water	28-33	mitochondrial calcium uptake 1	Homo sapiens	54-65
30508150-1	2019	We proposed and evaluated a water-equivalent diameter calculation without using a region of interest (ROI), (Dw,t) and compared it with the results of using a ROI fitted to the patient border (Dw,f).	Water	28-33	mitochondrial calcium uptake 1	Homo sapiens	54-65
31506286-5	2019	Superoxide dismutase 2 (SOD2) is a mitochondrial-specific antioxidant enzyme that dismutates superoxide to hydrogen peroxide, which is then converted to water by catalase and glutathione peroxidase.	Water	153-158	superoxide dismutase 2	Homo sapiens	24-28
31551934-12	2019	Among genes involved in ROS metabolism, the mRNA level of the H2O2 generating enzyme NOX4 was found upregulated in the presence of HG.	Water	62-66	NADPH oxidase 4	Homo sapiens	85-89
31254312-2	2019	The obtained CoFe-LDH hollow nanocubes could effectively catalyze water oxidation at a low overpotential of 270 mV @ 10 mA cm-2 , low Tafel slope of 58.3 mV dec-1 and show a long-term stability in alkali.	Water	66-71	deleted in esophageal cancer 1	Homo sapiens	157-162
31472313-2	2019	Hierarchical strand networks of hydrophobic PS/PB blocks anchored via PEO blocks to the water surface, with an internal phase-separation structure consisting of periodic domains of PS blocks surrounded and connected by a matrix of PB blocks, are generated by the interplay of interfacial amphiphilic block copolymer aggregation and polymer/polymer phase separation.	Water	88-93	surfactant protein B	Homo sapiens	44-49
33405568-6	2019	Bombyx mori silk fibroin was selected as the backbone of the adhesive network because it can be processed into an aqueous solution yet later be rendered insoluble in water through the assembly of its hydrophobic protein core.	Water	166-171	fibroin light chain	Bombyx mori	17-24
31422819-12	2019	Knockdown of got2a in zebrafish resulted in a brain developmental defect associated with seizure-like electroencephalography spikes, which could be rescued by supplying pyridoxine in embryo water.	Water	190-195	glutamic-oxaloacetic transaminase 2a, mitochondrial	Danio rerio	13-18
31252675-8	2019	Nevertheless, HAp addition promoted an increase of the pore wall thickness (from ~13 to 28 microm) and a decrease on porosity (from ~87% to 64%) and mean pore size (from ~12 to 20 microm), as well as on the degradability and water retention capabilities.	Water	225-230	reticulon 3	Homo sapiens	14-17
31233537-4	2019	When mobilized by the Arabidopsis thaliana beta-glucosidase 1 (AtBG1), the glucose ester-conjugated inactive form of ABA has proven to be a source of the active hormone that is essential for the adaptation of the plant to water deficit, as evidenced by the impaired stomatal closure of atbg1 mutants in response to water stress.	Water	222-227	Glycosyl hydrolase superfamily protein	Arabidopsis thaliana	43-61
31472313-2	2019	Hierarchical strand networks of hydrophobic PS/PB blocks anchored via PEO blocks to the water surface, with an internal phase-separation structure consisting of periodic domains of PS blocks surrounded and connected by a matrix of PB blocks, are generated by the interplay of interfacial amphiphilic block copolymer aggregation and polymer/polymer phase separation.	Water	88-93	surfactant protein B	Homo sapiens	47-49
31233537-4	2019	When mobilized by the Arabidopsis thaliana beta-glucosidase 1 (AtBG1), the glucose ester-conjugated inactive form of ABA has proven to be a source of the active hormone that is essential for the adaptation of the plant to water deficit, as evidenced by the impaired stomatal closure of atbg1 mutants in response to water stress.	Water	315-320	Glycosyl hydrolase superfamily protein	Arabidopsis thaliana	43-61
31486928-3	2019	The transmembrane water channel AQP1 is important for cardiorespiratory endurance (CE) because it influences fluid transfers in erythrocytes, endothelial, and pulmonary cells and is vital for transport of ammonium, bicarbonate, carbon dioxide, glycerol, nitric oxide, potassium ion, water, and trans-epithelial and renal water.	Water	18-23	aquaporin 1	Mus musculus	32-36
32704899-1	2019	Fat products have been historically thought to have too low water activity to harbor pathogens.	Water	60-65	FAT atypical cadherin 1	Homo sapiens	0-3
31486928-3	2019	The transmembrane water channel AQP1 is important for cardiorespiratory endurance (CE) because it influences fluid transfers in erythrocytes, endothelial, and pulmonary cells and is vital for transport of ammonium, bicarbonate, carbon dioxide, glycerol, nitric oxide, potassium ion, water, and trans-epithelial and renal water.	Water	283-288	aquaporin 1	Mus musculus	32-36
31037999-7	2019	Ang-(1-7) attenuated motor deficits at 3 dpi and improved performance in the Morris Water Maze at 28 dpi.	Water	84-89	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	0-8
31503666-0	2019	AuAg alloy film-based colorful SPR imaging sensor for highly sensitive immunodetection of benzo[a]pyrene in water.	Water	108-113	sepiapterin reductase	Homo sapiens	31-34
30926011-1	2019	Carboxymethyl chitosan (CMCS), a water-soluble derivative of chitosan possessing numerous enhanced physicochemical and biological properties, has emerged as a promising biopolymer carrier for new drug delivery.	Water	33-38	cerebral malaria susceptibility in CBA/N	Mus musculus	24-28
31228801-0	2019	Antidiabetic effects of water-soluble Korean pine nut protein on type 2 diabetic mice.	Water	24-29	NUT midline carcinoma family member 1	Homo sapiens	50-53
31507028-0	2019	Plasma Triggered O-S Bond and P-N Junction Near the Surface of SnS2 Nanosheet Array Enable Efficient Solar Water Oxidation.	Water	107-112	sodium voltage-gated channel alpha subunit 11	Homo sapiens	63-67
31228801-2	2019	This study evaluated the effects of water-soluble proteins of Korean pine nut obtained from a dilute alkali extract on carbohydrate metabolism of type 2 diabetic mice on a model of diabetes induced using a high fat diet combined with streptozotocin.	Water	36-41	NUT midline carcinoma family member 1	Homo sapiens	74-77
30801087-4	2019	Moreover, the catalytic performance of [1(H2O)2] was further accelerated by using [Ir(ppy)2(dtBubpy)](PF6) [Ir-PS-3] as a PS; 9886 TON (H2 per Rh ion) was verified after 12 h of irradiation.	Water	41-45	sperm associated antigen 17	Homo sapiens	102-105
31319075-8	2019	For water soluble SHP-n-Q derivative, the self-assembled structures have a size close to 100 nm at critical association concentration (0.01 M).	Water	4-9	nuclear receptor subfamily 0 group B member 2	Homo sapiens	18-21
30950579-11	2019	The characteristic time constant of the mass transport of water and hydroxide ions across the liquid phase within the ODC is determined to be tau  mt ,  H  2 O    0.176 s, whereas the time constant of oxygen mass transport into the reaction zone is several magnitudes smaller: tau  mt ,  O  2     1.70x10-6  s. Finally, a sensitivity analysis confirms that the overall performance is best improved by adjusting mass transport properties in the liquid phase.	Water	58-63	ornithine decarboxylase 1	Homo sapiens	118-121
31694346-7	2019	Additionally, the exposure of human sperm to H2O2 resulted in a significant decrease in sperm viability and motility and an increase in the levels of HSF1, HSP90, HSP60, HSP27, and eIF2alpha; all proteins involved in sensing and response to unfolded proteins.	Water	45-49	heat shock transcription factor 1	Homo sapiens	150-154
31556251-4	2019	By replacing K+ and PF6 - with H3 O+ and [FeCl4 ]- respectively, we obtained a new molecular ferroelectric [H3 O(18-crown-6)]+ [FeCl4 ]- , 1.	Water	31-36	sperm associated antigen 17	Homo sapiens	20-23
31163378-6	2019	Further, the toxicity of the treated water was assessed with the nematode Caenorhabditis elegans species at different time intervals by observing the expressions of important stress-responsive genes viz., sod-3, hsp-16.2, ctl-1,2,3 and gst-4.	Water	37-42	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	205-210
31009752-7	2019	The UVR8 (UV Resistance Locus 8) signaling pathway originated during the movement of plants from the deeper sea to shallow water and enabled plants to deal with ultraviolet B light (UV-B).	Water	123-128	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	4-8
31009752-7	2019	The UVR8 (UV Resistance Locus 8) signaling pathway originated during the movement of plants from the deeper sea to shallow water and enabled plants to deal with ultraviolet B light (UV-B).	Water	123-128	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	10-31
31363004-4	2019	Our results suggest that a catalytic Mg2+ ion makes inner-sphere contact with G33:N7 and outer-sphere coordination to the pro-R P of the scissile phosphate, promoting electrostatic stabilization of the dianionic transition state and neutralization of the developing charge of the leaving group through a metal-coordinated water molecule that is made more acidic by a hydrogen bond donated from the 2"OH of P32.	Water	322-327	complement C1q binding protein	Homo sapiens	406-409
31163378-6	2019	Further, the toxicity of the treated water was assessed with the nematode Caenorhabditis elegans species at different time intervals by observing the expressions of important stress-responsive genes viz., sod-3, hsp-16.2, ctl-1,2,3 and gst-4.	Water	37-42	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	212-220
31163378-6	2019	Further, the toxicity of the treated water was assessed with the nematode Caenorhabditis elegans species at different time intervals by observing the expressions of important stress-responsive genes viz., sod-3, hsp-16.2, ctl-1,2,3 and gst-4.	Water	37-42	Catalase-2	Caenorhabditis elegans	222-231
30547280-3	2019	The LIM was modified by arginine to improve its water solubility and biological activities.	Water	48-53	PDZ and LIM domain 5	Mus musculus	4-7
31781339-7	2019	In H2O2-treated DAergic neurons differentiated from PD-iPSCs, NC001-8 rescued the aberrant increase in ROS and cleaved caspase 3 by upregulating NRF2 and NQO1.	Water	3-7	down-regulator of transcription 1	Homo sapiens	62-69
30955600-3	2019	Current results showed that microbial transglutaminase (TGase) remarkably enhanced the gel strength, water holding capacity and viscoelasticity of HFT.	Water	101-106	transglutaminase 1	Homo sapiens	38-54
31033370-11	2019	Conclusions: The SBE-beta-CD inclusions offer a potential alternative strategy for ocular administration of poorly water-soluble drugs in the conjunctival sac.	Water	115-120	LOW QUALITY PROTEIN: adrenocortical dysplasia protein homolog	Oryctolagus cuniculus	21-28
30897425-3	2019	EXPERIMENTS: We use a recently developed humidity scanning (HS) QCM-D method to obtain water sorption-desorption isotherms of mucin films under controlled conditions where water diffusion is not the limiting factor, neither in the vapor phase nor in the glassy mucin film.	Water	87-92	LOC100508689	Homo sapiens	126-131
30955600-3	2019	Current results showed that microbial transglutaminase (TGase) remarkably enhanced the gel strength, water holding capacity and viscoelasticity of HFT.	Water	101-106	transglutaminase 1	Homo sapiens	56-61
30897425-3	2019	EXPERIMENTS: We use a recently developed humidity scanning (HS) QCM-D method to obtain water sorption-desorption isotherms of mucin films under controlled conditions where water diffusion is not the limiting factor, neither in the vapor phase nor in the glassy mucin film.	Water	172-177	LOC100508689	Homo sapiens	126-131
31429557-9	2019	Our simulation results along with the principal component analysis and water pathway analysis suggest four different interfaces as the most plausible: symmetrical transmembrane (TM)1,2,8; TM5; TM4; and TM4,5 AT1R dimer interfaces that consist of one inactive and one active protomer.	Water	71-76	angiotensin II receptor type 1	Homo sapiens	208-212
30826947-6	2019	In addition, both Rock1+/- and Rock2+/- mice showed deficits in long-term potentiation at hippocampal CA1 synapses and were impaired in spatial learning and memory based on the water maze and contextual fear conditioning tests.	Water	177-182	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	18-23
31481470-1	2019	The tight junctional pore-forming protein claudin-2 (CLDN-2) mediates paracellular Na+ and water transport in leaky epithelia and alters cancer cell proliferation.	Water	91-96	claudin 2	Mus musculus	42-51
30897425-4	2019	FINDINGS: We present new results on the water sorption-desorption behavior of glassy mucin films with nanoscale thicknesses.	Water	40-45	LOC100508689	Homo sapiens	85-90
30996002-7	2019	Critically, although mice deficient in IL-1 signaling have extensive acute inflammation following C. albicans water-soluble complex challenge, they do not develop coronary vasculitis.	Water	110-115	interleukin 1 complex	Mus musculus	39-43
31481470-1	2019	The tight junctional pore-forming protein claudin-2 (CLDN-2) mediates paracellular Na+ and water transport in leaky epithelia and alters cancer cell proliferation.	Water	91-96	claudin 2	Mus musculus	53-59
31413809-0	2019	DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines.	Water	39-44	cathepsin C	Homo sapiens	65-69
30921633-2	2019	The aim of this study was to investigate the influence of different water salinities on the expression of HSP70, PCNA and caspase-3 during spermatogenesis of Nile tilapia.	Water	68-73	proliferating cell nuclear antigen	Oreochromis niloticus	113-117
31347761-3	2019	The Tb-MOF exhibits a water-stable 3D bnn framework.	Water	22-27	lysine acetyltransferase 8	Homo sapiens	7-10
31413809-2	2019	The S2 pocket structure-activity relationship for these compounds shows significant gains in potency for DPP1 from interacting further with target residues and a network of water molecules in the binding pocket.	Water	173-178	cathepsin C	Homo sapiens	105-109
31413809-3	2019	Herein we describe the X-ray crystal structures of several of these compounds alongside an analysis of factors influencing the inhibitory potency toward DPP1 of which stabilization of the water network, demonstrated using Grand Canonical Monte Carlo simulations and free energy calculations, is attributed as a main factor.	Water	188-193	cathepsin C	Homo sapiens	153-157
31351645-4	2019	The interactions between CNC and PUE caused the increased thermal and thermo-mechanical properties, and decreased water absorption of nanocomposites.	Water	114-119	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	25-28
31145794-6	2019	Under salt conditions, AtHSFA7b regulates its target genes to mediate serial physiological changes, including maintaining cellular ion homeostasis, reducing water loss rate, decreasing reactive oxygen species accumulation, and adjusting osmotic potential, which ultimately leads to improved salt tolerance.	Water	157-162	winged-helix DNA-binding transcription factor family protein	Arabidopsis thaliana	23-31
31121880-3	2019	The ability of water incorporation was due to not only by the presence of oxygen vacancies, but also due to the presence of La-O blocks in the structure.	Water	15-20	interleukin 4 induced 1	Homo sapiens	124-128
31351645-5	2019	Importantly, the initial degradation temperature of PUE with 2 wt% content CNC (CNC/PUE2) increased by 21  C. CNC/PUE2 had the better comprehensive properties with the worse water absorption, which made CNC/PUE2 appealing in load bearing and outdoor applications.	Water	174-179	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	80-88
31351645-5	2019	Importantly, the initial degradation temperature of PUE with 2 wt% content CNC (CNC/PUE2) increased by 21  C. CNC/PUE2 had the better comprehensive properties with the worse water absorption, which made CNC/PUE2 appealing in load bearing and outdoor applications.	Water	174-179	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	110-118
31108985-6	2019	These results suggest that the CuS-CNF/GCE can be used as an efficient electrochemical sensor for the simultaneous determination of co-existing environmental pollutants such as HQ and CC in water environments with high selectivity and acceptable reproducibility.	Water	190-195	glycine decarboxylase	Homo sapiens	39-42
31351645-5	2019	Importantly, the initial degradation temperature of PUE with 2 wt% content CNC (CNC/PUE2) increased by 21  C. CNC/PUE2 had the better comprehensive properties with the worse water absorption, which made CNC/PUE2 appealing in load bearing and outdoor applications.	Water	174-179	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	110-118
31369782-0	2019	Binding interactions of a series of sulfonated water-soluble resorcinarenes with bovine liver catalase.	Water	47-52	catalase	Bos taurus	94-102
33405568-13	2019	Phenolic functionalization and oxidative cross-linking of silk fibroin was found to afford a new route to water-soluble, catechol-functionalized polymers, which were found to display excellent adhesion to mucosal tissue and whose secondary structure provides an additional mode to control strength and swelling of adhesive gels.	Water	106-111	fibroin light chain	Bombyx mori	63-70
31210211-1	2019	We demonstrate a ligand-free green chemical method for the rapid growth of nanoporous Ca0.35CoO2 thin films on sapphire and mica substrates from a water-based precursor ink, formulated by dissolving the precursor solid, composed of in situ prepared Ca2+-DMF and Co2+-DMF complexes.	Water	147-152	MHC class I polypeptide-related sequence A	Homo sapiens	38-42
31601240-7	2019	We found that mothe as a term of land usage was followed by mothee, nut"athee, gadnhe, or muinhe; these primarily refer to the topographic position of the parcel and the form of access to water for irrigation.	Water	188-193	NUT midline carcinoma family member 1	Homo sapiens	68-71
31555385-11	2019	The results revealed that miR-370 expression was downregulated and FOXO1 expression was increased in H9C2 cells induced by H2O2.	Water	123-127	forkhead box O1	Rattus norvegicus	67-72
31406952-1	2019	Arterial Spin Labeling (ASL) is a perfusion-based functional magnetic resonance imaging technique that uses water in arterial blood as a freely diffusible tracer to measure regional cerebral blood flow (rCBF) noninvasively.	Water	108-113	CCAAT/enhancer binding protein zeta	Rattus norvegicus	203-207
30849732-3	2019	In this study, a bioanalytical approach was used, measuring oxidative stress (Nrf2 activity), genotoxicity (micronucleus test), and aryl hydrocarbon receptor (AhR) activation to evaluate an innovative water treatment process, including suspended ion exchange, ozonation, in-line coagulation, ceramic microfiltration, and granular activated carbon.	Water	201-206	aryl hydrocarbon receptor	Homo sapiens	132-157
30849732-3	2019	In this study, a bioanalytical approach was used, measuring oxidative stress (Nrf2 activity), genotoxicity (micronucleus test), and aryl hydrocarbon receptor (AhR) activation to evaluate an innovative water treatment process, including suspended ion exchange, ozonation, in-line coagulation, ceramic microfiltration, and granular activated carbon.	Water	201-206	aryl hydrocarbon receptor	Homo sapiens	159-162
31258696-8	2019	Notably, disrupting miR-155 also increased nitric oxide (NO) production and the expression of endothelial NO synthase (eNOS), leading to downregulation of brain water content and Evans blue levels.	Water	161-166	microRNA 155	Mus musculus	20-27
31038506-3	2019	In this work, a new synthetic hot-injection strategy is presented to synthesize Ag2S NCs which are easily ligand exchangeable in water.	Water	129-134	angiotensin II receptor type 1	Homo sapiens	80-84
31555385-13	2019	The ELISA and flow cytometry assay revealed that miR-370 overexpression and FOXO1 silencing reversed H2O2-induced oxidative stress and apoptosis.	Water	101-105	forkhead box O1	Rattus norvegicus	76-81
31555385-14	2019	The results indicated that miR-370 could inhibit the oxidative stress and apoptosis of H9C2 cells induced by H2O2 by targeting FOXO1.	Water	109-113	forkhead box O1	Rattus norvegicus	127-132
30940592-8	2019	The reusability of as-synthesized NST/CS was assessed which due to its high recoverability can be applied as an effective catalyst for degradation of organic substances in water and wastewater especially for degradation of emerging pollutants such pharmaceutical pollutants.	Water	172-177	citrate synthase	Homo sapiens	38-40
31378493-18	2019	The water activities and diameters of the fat globules in the commercial milk powder were highly correlated with their oxidation stabilities during storage.	Water	4-9	FAT atypical cadherin 1	Homo sapiens	42-45
30763638-1	2019	A Mg2+-water bridge between the C-3, C-4 diketo moiety of fluoroquinolones and the conserved amino acid residues in the GyrA/ParC subunit is critical for the binding of a fluoroquinolone to a topoisomerase-DNA covalent complex.	Water	7-12	C-C motif chemokine ligand 18	Homo sapiens	125-129
31367070-10	2019	Results: The mean maximum IRP reached during baseline evaluation was 25 cm of water which was set as the maximum permissible limit of the IPRS.	Water	78-83	Wnt family member 2	Homo sapiens	26-29
29333914-0	2019	Hybrid PET/MRI imaging in healthy unsedated newborn infants with quantitative rCBF measurements using 15O-water PET.	Water	106-111	CCAAT/enhancer binding protein zeta	Rattus norvegicus	78-82
29333914-9	2019	In this study, we demonstrated for the first time, a minimally invasive PET/MRI method using low activity 15O-water PET for quantitative rCBF assessment in unsedated healthy newborn infants and found a white/grey matter CBF ratio similar to that of the adult human brain.	Water	110-115	CCAAT/enhancer binding protein zeta	Rattus norvegicus	137-141
29333914-9	2019	In this study, we demonstrated for the first time, a minimally invasive PET/MRI method using low activity 15O-water PET for quantitative rCBF assessment in unsedated healthy newborn infants and found a white/grey matter CBF ratio similar to that of the adult human brain.	Water	110-115	CCAAT/enhancer binding protein zeta	Rattus norvegicus	138-141
31543430-6	2019	RESULTS: In the present study, we found that H2O2-induced oxidative stress directly activated the AHR signaling pathway in melanocytes, whereas abnormal activation of AHR signaling pathway enhanced oxidative damage to mitochondria and melanocytes.	Water	45-49	aryl hydrocarbon receptor	Homo sapiens	98-101
31327223-7	2019	Results: Compared to healthy controls, IBS-D patients displayed elevated antral TRPA1 expression, which was associated with symptom scores after cold (4 C) water intake.	Water	156-161	transient receptor potential cation channel subfamily A member 1	Homo sapiens	80-85
31329997-2	2019	The investigated balneotherapeutic facility and its natural hot spa water are used for treatments and rehabilitations of rheumatic patients.	Water	68-73	surfactant protein A1	Homo sapiens	64-67
31601077-6	2019	A Morris water maze test was performed and showed that overexpression of miR-361-3p improved cognitive deficits in APP/PS1 mice.	Water	9-14	microRNA 361	Mus musculus	73-80
31576091-0	2019	High mobility group box-1 release from H2O2-injured hepatocytes due to sirt1 functional inhibition.	Water	39-43	high mobility group box 1	Mus musculus	0-25
30779993-7	2019	As for LA conversion, these water-born modulated ZrF MOFs are validated to successfully convert LA to GVL.	Water	28-33	metal regulatory transcription factor 1	Homo sapiens	49-52
30779993-9	2019	These water-born modulated ZrF also exhibit even higher catalytic activities than the typical DMF-based ZrF and reported Zr-based MOFs in LA conversion to GVL.	Water	6-11	metal regulatory transcription factor 1	Homo sapiens	27-30
30779993-9	2019	These water-born modulated ZrF also exhibit even higher catalytic activities than the typical DMF-based ZrF and reported Zr-based MOFs in LA conversion to GVL.	Water	6-11	metal regulatory transcription factor 1	Homo sapiens	104-107
31109623-8	2019	HgCl2 changed histological integrity of kidney and expression of 8-hydroxy-2"-deoxyguanosine (8-OHdG) while caused a decrease in aquaporin 1 (AQP1) water channel protein level.	Water	148-153	aquaporin 1	Rattus norvegicus	129-140
31124301-1	2019	SLC4A11 is a multifunctional membrane transporter involved with H+ transport, NH3 and alkaline pH stimulated H+ transport, and water transport.	Water	127-132	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Mus musculus	0-7
31562333-3	2019	While H2O2 exposure substantially decreases cell proliferation and increases p53, p21, p16, and p19 in cells from mice and rats, cells from spiny mice and rabbits are highly resistant to H2O2.	Water	6-10	interleukin 23, alpha subunit p19	Mus musculus	96-99
31109623-8	2019	HgCl2 changed histological integrity of kidney and expression of 8-hydroxy-2"-deoxyguanosine (8-OHdG) while caused a decrease in aquaporin 1 (AQP1) water channel protein level.	Water	148-153	aquaporin 1	Rattus norvegicus	142-146
31261964-8	2019	When PPN were separated from ethanol and re-dispersed in deionized water (pH 7), they were stable over four weeks, although some solubilization of proteins leading to a loss in particle size was observed.	Water	67-72	porcupine O-acyltransferase	Homo sapiens	5-8
31486461-6	2019	Galvanostatic cycling of these PBAs shows that the presence of Mg2+ in the lattice framework results in the dissolution of Mg1.5FeIII(CN)6 in water during oxidation.	Water	142-147	mucin 7, secreted	Homo sapiens	63-66
31486461-6	2019	Galvanostatic cycling of these PBAs shows that the presence of Mg2+ in the lattice framework results in the dissolution of Mg1.5FeIII(CN)6 in water during oxidation.	Water	142-147	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	123-126
31490518-5	2019	Starting from the metastable coiled conformations in water, hIAPP monomers tend to adopt transient alpha-helical and beta-sheet structures when adsorbing to the membrane surface.	Water	53-58	islet amyloid polypeptide	Homo sapiens	60-65
31641423-13	2019	H2O2 leads to SGK1 overexpression in HK-2 cells, which protects human renal tubule cells from oxidative stress injury by improving mitochondrial function and inactivating GSK3beta.	Water	0-4	glycogen synthase kinase 3 beta	Homo sapiens	171-179
31551758-4	2019	Here, we observe that appoptosin protein levels are induced by hydrogen peroxide (H2O2) exposure through the inhibition of proteasomal appoptosin degradation.	Water	82-86	solute carrier family 25 member 38	Homo sapiens	22-32
31551758-4	2019	Here, we observe that appoptosin protein levels are induced by hydrogen peroxide (H2O2) exposure through the inhibition of proteasomal appoptosin degradation.	Water	82-86	solute carrier family 25 member 38	Homo sapiens	135-145
31551758-6	2019	Importantly, knockdown of appoptosin can ameliorate H2O2-induced JNK activation and apoptosis in primary neurons.	Water	52-56	solute carrier family 25 member 38	Homo sapiens	26-36
31128511-6	2019	The hydrodynamic diameter of modified, water soluble Ag2S QDs is about 10 nm and is only slightly larger than their original size.	Water	39-44	angiotensin II receptor type 1	Homo sapiens	53-57
31267390-4	2019	As a result, the purified water, with lower total dissolved solids (TDS) and pH, was a suitable candidate for injection into the adjacent wells of the crude oil desalting unit.	Water	26-31	phenylalanine hydroxylase	Homo sapiens	77-79
31267390-8	2019	The analysis shows that the refined water from the reverse osmosis (RO) process was a suitable and low-cost economical option for injection in onshore and offshore fields, due to the low amount of salts, the concentration of susceptible ions in scaling formation, and the appropriate pH.	Water	36-41	phenylalanine hydroxylase	Homo sapiens	284-286
30474149-6	2019	This method was then successfully applied to quantify the phosvitin-Fe(III) loading in mayonnaise water phase by liquid NMR, whereas 31 P NMR MAS could only provide a qualitative measure.	Water	98-103	casein kinase 2 beta	Homo sapiens	58-67
31480597-0	2019	Production of SnS2 Nanostructure as Improved Light-Assisted Electrochemical Water Splitting.	Water	76-81	sodium voltage-gated channel alpha subunit 11	Homo sapiens	14-18
31210007-3	2019	A beta-cyclodextrin polymer linked with tetrafluoroterephthalonitrile (TFN-CDP) has high affinity for cationic and many neutral MPs from contaminated water because of anionic groups incorporated during the polymerization.	Water	150-155	cut like homeobox 1	Homo sapiens	75-78
31396614-4	2019	Herein we present the water soluble MEG-PBI showing interesting aggregation in water and in the solid state.	Water	22-27	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	36-39
31396614-4	2019	Herein we present the water soluble MEG-PBI showing interesting aggregation in water and in the solid state.	Water	79-84	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	36-39
31396614-5	2019	Unlike its hydrophobic counterparts, MEG-PBI aggregates in water with increasing temperature, indicating entropy-driven self-assembly.	Water	59-64	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	37-40
31283237-6	2019	We also demonstrate the use of PES-Learn machine learning models in carrying out high-level vibrational configuration interaction computations on water and formaldehyde.	Water	146-151	pescadillo ribosomal biogenesis factor 1	Homo sapiens	31-34
31398818-6	2019	When both subunits were initially positioned in the same bilayer, SP-B induced the formation of a defect in the bilayer, with water penetrating into the centre of the bilayer.	Water	126-131	surfactant protein B	Homo sapiens	66-70
31386675-11	2019	Moreover, our data support the involvement of ICs in water homeostasis, at least partly mediated by V-ATPase, in a sex-dependent manner.	Water	53-58	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	100-108
31382552-2	2019	In this work, a synthesis method for bone morphogenetic protein (BMP-2)-loaded PLGA NPs was developed and optimized, in order to carry out and control the release of BMP-2, based on the double-emulsion (water/oil/water, W/O/W) solvent evaporation technique.	Water	203-208	bone morphogenetic protein 2	Homo sapiens	65-70
31382552-2	2019	In this work, a synthesis method for bone morphogenetic protein (BMP-2)-loaded PLGA NPs was developed and optimized, in order to carry out and control the release of BMP-2, based on the double-emulsion (water/oil/water, W/O/W) solvent evaporation technique.	Water	203-208	bone morphogenetic protein 2	Homo sapiens	166-171
31382552-2	2019	In this work, a synthesis method for bone morphogenetic protein (BMP-2)-loaded PLGA NPs was developed and optimized, in order to carry out and control the release of BMP-2, based on the double-emulsion (water/oil/water, W/O/W) solvent evaporation technique.	Water	213-218	bone morphogenetic protein 2	Homo sapiens	65-70
31382552-2	2019	In this work, a synthesis method for bone morphogenetic protein (BMP-2)-loaded PLGA NPs was developed and optimized, in order to carry out and control the release of BMP-2, based on the double-emulsion (water/oil/water, W/O/W) solvent evaporation technique.	Water	213-218	bone morphogenetic protein 2	Homo sapiens	166-171
31141415-6	2019	We previously reported that nesfatin-1 inhibited angiotensin II-induced water drinking in male rats but found no effect of nesfatin-1 in females in diestrus.	Water	72-77	nucleobindin 2	Rattus norvegicus	28-38
30790544-0	2019	BFSP1 C-terminal domains released by post-translational processing events can alter significantly the calcium regulation of AQP0 water permeability.	Water	129-134	beaded filament structural protein 1 L homeolog	Xenopus laevis	0-5
31273977-6	2019	Satisfied recoveries have also been obtained for detection of Cr3+ and Pb2+ in real water samples.	Water	84-89	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	62-65
31315302-6	2019	The results revealed a very high surface water component explained by urbanization of Sete Lagoas, which hampers the recharge of 7.9 hm3 yr-1 of storm water.	Water	41-46	cholinergic receptor muscarinic 3	Homo sapiens	133-136
31315302-6	2019	The results revealed a very high surface water component explained by urbanization of Sete Lagoas, which hampers the recharge of 7.9 hm3 yr-1 of storm water.	Water	151-156	cholinergic receptor muscarinic 3	Homo sapiens	133-136
31315302-7	2019	They also exposed a very large negative difference (-8.3 hm3 yr-1) between groundwater availability (6.3 hm3 yr-1) and current groundwater abstraction from the karst aquifer (14.6 hm3 yr-1), which is in keeping with previously reported water table declines around drilled wells that can reach 48 m in old wells used for public water supply.	Water	81-86	cholinergic receptor muscarinic 3	Homo sapiens	57-60
31315302-7	2019	They also exposed a very large negative difference (-8.3 hm3 yr-1) between groundwater availability (6.3 hm3 yr-1) and current groundwater abstraction from the karst aquifer (14.6 hm3 yr-1), which is in keeping with previously reported water table declines around drilled wells that can reach 48 m in old wells used for public water supply.	Water	81-86	cholinergic receptor muscarinic 3	Homo sapiens	105-108
31315302-7	2019	They also exposed a very large negative difference (-8.3 hm3 yr-1) between groundwater availability (6.3 hm3 yr-1) and current groundwater abstraction from the karst aquifer (14.6 hm3 yr-1), which is in keeping with previously reported water table declines around drilled wells that can reach 48 m in old wells used for public water supply.	Water	81-86	cholinergic receptor muscarinic 3	Homo sapiens	105-108
31413809-0	2019	DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines.	Water	39-44	cathepsin C	Homo sapiens	0-4
30559078-8	2019	The developed sensor was successfully employed for the determination of NDF in real lake water, commercial NDF tablet and urine samples with acceptable recovery.	Water	89-94	neuregulin 1	Homo sapiens	72-75
31041308-2	2019	Hence, a new 3D metal-organic framework (MOF) [Cd2(btc)(bib)(HCOO)(H2O) H2O]n (1) has been synthesized using mixed ligand strategy by solvothermal reaction of cadmium acetate with two ligands viz.	Water	67-70	lysine acetyltransferase 8	Homo sapiens	13-45
31041308-2	2019	Hence, a new 3D metal-organic framework (MOF) [Cd2(btc)(bib)(HCOO)(H2O) H2O]n (1) has been synthesized using mixed ligand strategy by solvothermal reaction of cadmium acetate with two ligands viz.	Water	72-75	lysine acetyltransferase 8	Homo sapiens	13-45
30843538-0	2019	A Cd-MOF as a fluorescent probe for highly selective, sensitive and stable detection of antibiotics in water.	Water	103-108	lysine acetyltransferase 8	Homo sapiens	5-8
30843538-4	2019	The highly selective response of this MOF probe to ceftriaxone sodium (an antibiotic) can reach up to the ppb level in water, along with a fast response time, acid and alkali resistance, and anti-interference ability.	Water	119-124	lysine acetyltransferase 8	Homo sapiens	38-41
30856299-0	2019	MOF-Based Hierarchical Structures for Solar-Thermal Clean Water Production.	Water	58-63	lysine acetyltransferase 8	Homo sapiens	0-3
30576237-6	2019	Conversely, if NKCC1 works in the net influx mode, it would have an absorptive function, contributing to intracellular Cl- concentration ([Cl-]i) and cell water volume (CWV) maintenance needed for CSF secretion.	Water	155-160	solute carrier family 12, member 2	Mus musculus	15-20
30576237-8	2019	NKCC1-mediated ion and associated water fluxes are tightly linked, thus their direction is inferred by measuring CWV changes.	Water	34-39	solute carrier family 12, member 2	Mus musculus	0-5
31022570-5	2019	Integration of GPCR crystallography or homology modelling with FMO reveals atomistic details of the individual contributions of each residue and water molecule towards ligand binding, including an analysis of their chemical nature.	Water	145-150	G protein-coupled receptor 166 pseudogene	Homo sapiens	15-19
30703746-6	2019	Berries also protected the aorta from fibrosis and modulated the expression of aquaporin-1, a channel involved in endothelial water and nitric oxide permeability.	Water	126-131	aquaporin 1	Rattus norvegicus	79-90
31142117-4	2019	The optimal water-soluble d-MoS2 NSs display excellent HER activities, including a low overpotential of 71.5 mV at a current density of -10 mA cm-2, a small Tafel slope of 58.3 mV dec-1, and good cycling stability.	Water	12-17	deleted in esophageal cancer 1	Homo sapiens	180-185
30755137-7	2019	The brain water content at 24 h post-insult was significantly smaller in PAI-2-KO mice.	Water	10-15	serine (or cysteine) peptidase inhibitor, clade B, member 2	Mus musculus	73-78
30909048-7	2019	There were few studies describing ESP activities related to mechanized piped water systems.	Water	77-82	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	34-37
30965132-0	2019	Applicability and reproducibility of 2D multi-slice GRASE myelin water fraction with varying acquisition acceleration.	Water	65-70	glutathione-disulfide reductase	Homo sapiens	52-57
31150248-2	2019	Here, we present the design and characterization of pH-sensitive nano-self-assemblies of the poorly water-soluble anticancer drug 2-hydroxyoleic acid (2OHOA) with glycerol monooleate (GMO).	Water	100-105	phenylalanine hydroxylase	Homo sapiens	52-54
31058500-7	2019	In contrast, binding of GTP to EF-Tu is entropically driven by the liberation of bound water during the GDP- to GTP-bound transition.	Water	87-92	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	31-36
31150248-4	2019	zeta-potential measurements highlight that the pH-driven deprotonation of the carboxylic group of 2OHOA, and the resulting charge-repulsions at the lipid-water interface account for these nanostructural alterations.	Water	154-159	phenylalanine hydroxylase	Homo sapiens	47-49
31117447-6	2019	The light-to-heat conversion efficiency (eta) of water evaporation reached a value of 82% for our as-prepared Final-PTFE membrane under two sun irradiation conditions.	Water	49-54	endothelin receptor type A	Homo sapiens	41-44
31161168-1	2019	The reaction OH + HO2  H2O + O2 is of great significance in interstellar media, the atmosphere, and combustion.	Water	23-26	heme oxygenase 2	Homo sapiens	18-21
31094202-6	2019	We revealed that water-soluble PMB at the 30 mol % MPC unit (i.e., PMB30W) penetrated into the cytosol of model mammalian cells without any proton leaks, in contrast to conventional cell-penetrating peptides, TAT and R8 as well as the surfactant, Triton X-100.	Water	17-22	tyrosine aminotransferase	Homo sapiens	209-219
29607747-3	2019	This paper describes a polar-HPLC method employed polar RP-C18 (5 mum, 250 x 4.6 mm) using pure water as the mobile phase and a column temperature of 30  C, coupled with a flow rate at 1.0 mL/min and detected under a UV detector at wavelength of 210 nm.	Water	96-101	RNA polymerase II, I and III subunit H	Homo sapiens	56-62
31093695-8	2019	The probe was further successfully applied to determine CNO- in real samples such as tap water, human urine and serum samples, which offered a promising approach in practical applications.	Water	89-94	biogenesis of lysosomal organelles complex 1 subunit 4	Homo sapiens	56-59
30802033-5	2019	The detection method showed an ultralow detection limit of 1.4 nM (nanomole) for Cr3+ in ultrapure water and 11.5 nM in human serum sample, respectively.	Water	99-104	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	81-84
30802033-6	2019	On the basis of colorimetry, the lowest concentration of ~50 nM for Cr3+ in ultrapure water and human serum can be detected by the naked eye.	Water	86-91	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	68-71
31312077-3	2019	In O2- bound structure, hydration potentiality of CuRS (Cu1106) type-I copper center is observed to be unique, where two water molecules (W1-W2) are interacting with the metal sites, which was not found in X-ray structures of hCP.	Water	121-126	alpha-1-microglobulin/bikunin precursor	Homo sapiens	226-229
30499006-5	2019	We found that soluble FKN over expression by cells lining the ventricles significantly improved cognitive performance on the novel mouse recognition and radial arm water maze tasks.	Water	164-169	chemokine (C-X3-C motif) ligand 1	Mus musculus	22-25
31212731-5	2019	In August-September 2005 Hurricanes Katrina and Rita storm surges flooded parts of the city with sediment-loaded water.	Water	113-118	RBPJ interacting and tubulin associated 1	Homo sapiens	48-52
31112175-8	2019	Chloride abstraction of 5 with TlPF6 in tetrahydrofuran (thf) afforded [Ir(tpp)(PPh3)(thf)](PF6) (6) that reacted with CsOH H2O and Li2S to give the hydroxo [Ir(tpp)(OH)(PPh3)] (7) and hydrosulfido [Ir(tpp)(PPh3)(SH)] (8) complexes, respectively.	Water	124-127	sperm associated antigen 17	Homo sapiens	33-36
30758936-0	2019	Hierarchical SnS2/CuInS2 Nanosheet Heterostructure Films Decorated with C60 for Remarkable Photoelectrochemical Water Splitting.	Water	112-117	sodium voltage-gated channel alpha subunit 11	Homo sapiens	13-17
30758936-2	2019	Herein, hierarchical SnS2/CuInS2 nanosheet heterostructure porous films were fabricated and decorated with C60 to form photocathodes for PEC water reduction.	Water	141-146	sodium voltage-gated channel alpha subunit 11	Homo sapiens	21-25
33117975-2	2019	The retention of these peptides on the Sil-ODA18 stationary phase decreased as the water content in the mobile phase was lowered from 80% (v/v) to ca.	Water	83-88	STIL centriolar assembly protein	Homo sapiens	39-42
31058518-2	2019	The resulting hybrid films were statically hydrophilic (static water contact angles (CAs) were in the range of 30-45 ), but water droplets (50 muL) could move smoothly on an inclined surface (minimum sliding angle was 6 ) without pinning or tailing because of low CA hysteresis (5 +- 1 ).	Water	124-129	tripartite motif containing 37	Homo sapiens	143-146
33117975-7	2019	These changes in the retention behaviour of these TRAP peptides are consistent with the generation of water or acetonitrile clusters in the mobile phase depending on the volume fractions of the organic solvent as the Sil-ODA18 stationary phase transitions from its crystalline to its isotropic state.	Water	102-107	STIL centriolar assembly protein	Homo sapiens	217-220
31006946-7	2019	Our findings highlight the key role played by water molecules in mediating H-bond formation in beta2 -sheets commonly found in amyloidogenic glutamic acid-rich aggregates.	Water	46-51	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	95-100
30614619-8	2019	The results suggested that NTN-1 improved the neurological deficits, reduced the brain water content and alleviated neuronal apoptosis.	Water	87-92	netrin 1	Mus musculus	27-32
31263329-9	2019	Twenty-six percent of recreational water were identified as Acanthamoeba spp.	Water	35-40	histocompatibility minor 13	Homo sapiens	73-76
30735295-0	2019	Aluminum-Tailored Energy Level and Morphology of Co3- x Alx O4 Porous Nanosheets toward Highly Efficient Electrocatalysts for Water Oxidation.	Water	126-131	hematopoietic SH2 domain containing	Homo sapiens	56-59
31137508-5	2019	Our results showed that EAP water extract significantly inhibits ROS production, adipogenesis, and lipogenesis during differentiation of 3T3-L1 preadipocytes.	Water	28-33	glutamyl aminopeptidase	Mus musculus	24-27
31137508-9	2019	These results suggest that EAP water extract can exert ROS-linked anti-obesity effect through the mechanism that might involve inhibition of ROS production, adipogenesis and lipogenesis via an activating AMPK signaling pathway.	Water	31-36	glutamyl aminopeptidase	Mus musculus	27-30
31041964-7	2019	Powder second-harmonic generation (SHG) measurements indicate that beta-RbCdI3 H2O and CsCdI3 H2O show phase-matchable SHG responses of 2.7 and 2.6 times that of KH2PO4 (KDP).	Water	79-82	WNK lysine deficient protein kinase 1	Homo sapiens	170-173
31023968-1	2019	Aquaporin 1 (AQP1) is a glycoprotein responsible for water passive transport quickly across biological membrane.	Water	53-58	aquaporin 1	Mus musculus	0-11
31023968-1	2019	Aquaporin 1 (AQP1) is a glycoprotein responsible for water passive transport quickly across biological membrane.	Water	53-58	aquaporin 1	Mus musculus	13-17
31023968-7	2019	Mechanistic studies confirmed that AQP1 gene products regulate the secretory function and participated in balancing the osmotic water flux across the peritoneal membrane.	Water	128-133	aquaporin 1	Mus musculus	35-39
30808749-1	2019	Cytochrome c oxidase (CcO) reduces dioxygen to water and harnesses the chemical energy to drive proton translocation across the inner mitochondrial membrane by an unresolved mechanism.	Water	47-52	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
30808749-1	2019	Cytochrome c oxidase (CcO) reduces dioxygen to water and harnesses the chemical energy to drive proton translocation across the inner mitochondrial membrane by an unresolved mechanism.	Water	47-52	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
31041964-7	2019	Powder second-harmonic generation (SHG) measurements indicate that beta-RbCdI3 H2O and CsCdI3 H2O show phase-matchable SHG responses of 2.7 and 2.6 times that of KH2PO4 (KDP).	Water	94-97	WNK lysine deficient protein kinase 1	Homo sapiens	170-173
31049535-6	2019	Chromic behaviour and its mechanism were investigated using IR, solid-state UV-Vis, XRD, PXRD and TGA indicating the coordination/de-coordination of water molecules to be the key factor that influences the colour changes.	Water	149-154	T-box transcription factor 1	Homo sapiens	98-101
30600941-3	2019	In this work, induced CPL of [Eu(pda)2 ]- and [Eu(bda)2 ]- in water solutions containing a mixture of d- and l- amino acids were examined.	Water	62-67	bone morphogenetic protein 2	Homo sapiens	50-55
30907040-0	2019	Doping-Induced Amorphization, Vacancy, and Gradient Energy Band in SnS2 Nanosheet Arrays for Improved Photoelectrochemical Water Splitting.	Water	123-128	sodium voltage-gated channel alpha subunit 11	Homo sapiens	67-71
31156579-8	2019	Extended spectrum beta lactamase (ESBL) containing E. coli with the bla ctx-M was found in three water and nine fecal isolates while bla cmy-2 in 19 water and 16 fecal isolates.	Water	97-102	beta-lactamase	Escherichia coli	68-71
30630617-3	2019	IM-BIM@Sil in a methanol/water (60:40, v/v) solution at 60  C extracted the highest amount of aristolochic acid (16.69 mg/g) compared to the other sorbents examined.	Water	25-30	STIL centriolar assembly protein	Homo sapiens	7-10
30739425-2	2019	Methods: BMP-2 gelatin/chitosan hydrogel microspheres were prepared by water-in-oil solution.	Water	71-76	bone morphogenetic protein 2	Homo sapiens	9-14
30990703-4	2019	The RPMD rate coefficients for H + H2O2   OH + H2O are larger than H + H2O2   H2 + HO2, but at very low temperatures below the room temperature, the H2 + HO2 channel becomes dominant due to significant quantum tunneling effects in the H atom transfer process.	Water	35-38	heme oxygenase 2	Homo sapiens	154-157
31156579-8	2019	Extended spectrum beta lactamase (ESBL) containing E. coli with the bla ctx-M was found in three water and nine fecal isolates while bla cmy-2 in 19 water and 16 fecal isolates.	Water	149-154	beta-lactamase	Escherichia coli	133-136
30849732-12	2019	AhR activity was observed in the water produced by the conventional process and in the raw water, but the activity was clearly decreased by the ozonation step in the innovative water treatment process.	Water	33-38	aryl hydrocarbon receptor	Homo sapiens	0-3
30849732-12	2019	AhR activity was observed in the water produced by the conventional process and in the raw water, but the activity was clearly decreased by the ozonation step in the innovative water treatment process.	Water	91-96	aryl hydrocarbon receptor	Homo sapiens	0-3
30610951-2	2019	Thyrotropin releasing hormone (TRH), a water soluble drug used for treating suicidal patients, was incorporated into a fast degrading poly(sebacic anhydride) (PSA) NPs.	Water	39-44	thyrotropin releasing hormone	Homo sapiens	0-29
30610951-2	2019	Thyrotropin releasing hormone (TRH), a water soluble drug used for treating suicidal patients, was incorporated into a fast degrading poly(sebacic anhydride) (PSA) NPs.	Water	39-44	thyrotropin releasing hormone	Homo sapiens	31-34
30707930-10	2019	Intriguingly, water-soluble fraction of PM2.5 were found responsible for the enhancement of FcepsilonRI-mediated signaling, mast cell degranulation, and cytokine production.	Water	14-19	Fc epsilon receptor Ia	Homo sapiens	92-103
30610951-8	2019	Further, the in vitro release profile of TRH from NPs lasted for 12 h with most TRH released within the first hour in water.	Water	118-123	thyrotropin releasing hormone	Homo sapiens	41-44
30849732-12	2019	AhR activity was observed in the water produced by the conventional process and in the raw water, but the activity was clearly decreased by the ozonation step in the innovative water treatment process.	Water	91-96	aryl hydrocarbon receptor	Homo sapiens	0-3
30610951-8	2019	Further, the in vitro release profile of TRH from NPs lasted for 12 h with most TRH released within the first hour in water.	Water	118-123	thyrotropin releasing hormone	Homo sapiens	80-83
30707930-11	2019	Our data suggest that PM2.5, mainly water-soluble fraction of PM2.5, could affect mast cell activation through enhancing FcepsilonRI-mediated signaling.	Water	36-41	Fc epsilon receptor Ia	Homo sapiens	121-132
31052217-7	2019	The products NHC-B(S2C2H4)(C C-R1) are remarkably stable towards water and air, which suggests their use as boron-based building blocks for applications akin to oxygen-based boronate esters.	Water	65-70	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	29-33
30736297-4	2019	In the 6-hydroxydopamine (6-OHDA)-injected mouse model, cognitive and motor function, and the levels of alpha-syn, Abeta, and oligomer A11 after inhibition of NOX4 expression in the hippocampal dentate gyrus (DG) were measured by the Morris water maze, novel object recognition, rotation, and rotarod tests, as well as immunoblotting and immunohistochemistry.	Water	241-246	NADPH oxidase 4	Mus musculus	159-163
30616342-1	2019	In order to accurately and conveniently measure temperature and water content in bioethanol, a dual-function ratiometric luminescence sensor has been fabricated successfully based on mixed lanthanide metal-organic frameworks (MOFs) Eu0.02Dy0.18-MOF.	Water	64-69	lysine acetyltransferase 8	Homo sapiens	226-229
30616342-2	2019	In this MOF, the two lanthanides and ligand (H4L) form three luminescence centers, and they have different sensitivity toward water and temperature.	Water	126-131	lysine acetyltransferase 8	Homo sapiens	8-11
30988011-1	2019	BACKGROUND: Arginine-vasopressin (AVP) binding to vasopressin V2 receptors promotes redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane of renal collecting duct principal cells.	Water	106-111	arginine vasopressin	Mus musculus	12-32
30951053-1	2019	Ultrasmall and monodisperse sulfur nanoparticle (S-NP) intercalated CoAl-layered double hydroxide (CoAl-LDH) electrocatalyst exhibits an excellent electrocatalytic activity towards water oxidation with a low overpotential of 250 mV at a high current density of 7.9 mA cm-2 and a Tafel slope of 61 mV dec-1 at the neutral pH condition.	Water	181-186	deleted in esophageal cancer 1	Homo sapiens	300-305
30988011-1	2019	BACKGROUND: Arginine-vasopressin (AVP) binding to vasopressin V2 receptors promotes redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane of renal collecting duct principal cells.	Water	106-111	arginine vasopressin	Mus musculus	34-37
30616342-3	2019	Using the ratio of luminescence intensity at 416 and 614 nm, the MOF could quantitatively determine the concentration of water in dry ethanol and in bioethanol with recoveries of 91% -107%, and a detection limit of 0.1%, which is much lower than that in hydrated ethyl alcohol fuel (AEHC), 0.8% in China, 1.0% in the United States, and 4.9% in Brazil.	Water	121-126	lysine acetyltransferase 8	Homo sapiens	65-68
30508412-4	2019	The present results are the first to demonstrate that PKC/p38 MAPK signaling is involved in ANGII-induced water and sodium intake and oxytocin (OT) secretion in OVX rats.	Water	106-111	mitogen activated protein kinase 14	Rattus norvegicus	58-61
30826056-2	2019	Structural data demonstrate that two metal ions and two water molecules are located in the active site of PP5 and are involved in the dephosphorylations of the substrate.	Water	56-61	protein phosphatase 5 catalytic subunit	Homo sapiens	106-109
30508412-4	2019	The present results are the first to demonstrate that PKC/p38 MAPK signaling is involved in ANGII-induced water and sodium intake and oxytocin (OT) secretion in OVX rats.	Water	106-111	mitogen activated protein kinase 3	Rattus norvegicus	62-66
30658295-4	2019	In the water industry, gas chlorination units require strong HSE plans to mitigate the possibility of chlorine explosion and leak.	Water	7-12	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	61-64
30826056-3	2019	Recently, the catalytic reaction of PP5 has been studied by a density functional theory (DFT) method, and the role of the water molecules in regulating the substrate binding of PP5 was explored by our previous molecular dynamics (MD) study.	Water	122-127	protein phosphatase 5 catalytic subunit	Homo sapiens	36-39
31114482-8	2019	Prolonged (30 consecutive days), voluntary alcohol intake under the homecage 2-bottle "alcohol vs. water" regimen strongly increased CGRP intensity in BNST of sP rats in a subnucleus-specific manner: in BNST-AL, BNST-AVm, and BNST-AM.	Water	99-104	calcitonin-related polypeptide alpha	Rattus norvegicus	133-137
30724601-7	2019	"Spa pool of medicinal water" treatment was the most common care in each year which incidence showed a downward trend during the past years: 2 544  617 treatments were performed in 2009 but 2016 showed only 1 898  338 treatments.	Water	23-28	surfactant protein A1	Homo sapiens	1-4
30826056-3	2019	Recently, the catalytic reaction of PP5 has been studied by a density functional theory (DFT) method, and the role of the water molecules in regulating the substrate binding of PP5 was explored by our previous molecular dynamics (MD) study.	Water	122-127	protein phosphatase 5 catalytic subunit	Homo sapiens	177-180
30826056-10	2019	Furthermore, combined with the simulation data of our previous study, the sequential steps for PP5 binding of the substrate, the two active site water molecules, and the two Mn2+ ions are proposed.	Water	145-150	protein phosphatase 5 catalytic subunit	Homo sapiens	95-98
30704045-3	2019	Based on these considerations, the purpose of this work was to use the strategy of complexation with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in order to obtain an aqueous preparation of DAS, which is characterized by a low water solubility (6.49 x 10-4 mg/mL).	Water	228-233	beta-carotene oxygenase 1	Mus musculus	137-144
30617606-8	2019	For public water supplies, having a first PC score for health standards (primarily summarized selenium, nitrate, and lead) in the third quintile (RR = 1.101, 95% CrI 1.019-1.188), fourth quintile (RR = 1.088, 95% CrI 1.003-1.180), or fifth quintile (RR = 1.115, 95% CrI 1.026-1.213) was associated with an increase in 2010 diabetes prevalence compared with the first quintile.	Water	11-16	EP300 interacting inhibitor of differentiation 1	Homo sapiens	162-167
30656304-4	2019	The rate of HO2 production decreased significantly over the range of relative humidities between 8.7 and 36.9%, suggesting competitive adsorption of water vapour inhibits HO2 production.	Water	149-154	heme oxygenase 2	Homo sapiens	12-15
30656304-4	2019	The rate of HO2 production decreased significantly over the range of relative humidities between 8.7 and 36.9%, suggesting competitive adsorption of water vapour inhibits HO2 production.	Water	149-154	heme oxygenase 2	Homo sapiens	171-174
30656304-6	2019	The increased coverage of H2O onto the TiO2 aerosol surface may inhibit HO2 production by decreasing the effective surface area of the TiO2 particle and lowering the binding energy of O2 on the aerosol surface, hence shortening its desorption lifetime.	Water	26-29	heme oxygenase 2	Homo sapiens	72-75
30592213-10	2019	Water addition to guanine radical cation is the preferred path for forming 8oxoG at pH 2.5.	Water	0-5	phenylalanine hydroxylase	Homo sapiens	84-86
30380007-2	2019	Activation of MR by aldosterone in the kidney controls water and electrolyte homeostasis.	Water	55-60	nuclear receptor subfamily 3 group C member 2	Homo sapiens	14-16
30565613-1	2019	A Cd(ii)-based metal-organic framework (MOF) {[Cd(PA)(4,4"-bpy)2](H2O)}n (where, PA = pamoic acid, and bpy = bipyridine) has been demonstrated to have trifunctional properties, namely as (i) an efficient and selective adsorbent for dyes, (ii) a visible-light-active photocatalyst for the degradation of dyes and (iii) a photocatalyst for Cr(vi) reduction.	Water	66-69	lysine acetyltransferase 8	Homo sapiens	15-44
30572703-0	2019	Membrane-Water Partition Coefficients to Aid Risk Assessment of Perfluoroalkyl Anions and Alkyl Sulfates.	Water	9-14	activation induced cytidine deaminase	Homo sapiens	41-44
30348394-2	2019	A novel, ratiometric water-soluble fluorescent probe (FLM) for beta-gal was developed.	Water	21-26	galactosidase beta 1	Homo sapiens	63-71
30565626-6	2019	Benefiting from the decent water adsorption/dissociation capability of the edge sites, the optimal MoS2/MoSe2 heterostructure shows exceptional catalytic activity in 1 M KOH with an overpotential of 235 mV at 10 mA cm-2 and a Tafel slope of 96 mV dec-1, which is substantially improved as compared with the individual MoSe2 (330 mV, 135 mV dec-1) and MoS2 (400 mV, 157 mV dec-1).	Water	27-32	deleted in esophageal cancer 1	Homo sapiens	247-252
30565626-6	2019	Benefiting from the decent water adsorption/dissociation capability of the edge sites, the optimal MoS2/MoSe2 heterostructure shows exceptional catalytic activity in 1 M KOH with an overpotential of 235 mV at 10 mA cm-2 and a Tafel slope of 96 mV dec-1, which is substantially improved as compared with the individual MoSe2 (330 mV, 135 mV dec-1) and MoS2 (400 mV, 157 mV dec-1).	Water	27-32	deleted in esophageal cancer 1	Homo sapiens	340-345
30565626-6	2019	Benefiting from the decent water adsorption/dissociation capability of the edge sites, the optimal MoS2/MoSe2 heterostructure shows exceptional catalytic activity in 1 M KOH with an overpotential of 235 mV at 10 mA cm-2 and a Tafel slope of 96 mV dec-1, which is substantially improved as compared with the individual MoSe2 (330 mV, 135 mV dec-1) and MoS2 (400 mV, 157 mV dec-1).	Water	27-32	deleted in esophageal cancer 1	Homo sapiens	340-345
27996318-7	2019	Pro-BNP acts as a key regulator in the homeostasis of water and salt excretion and in the maintenance of blood pressure, mainly by inhibiting the renin-angiotensin-aldosterone axis and blocking the sympathetic nervous activity.	Water	54-59	natriuretic peptide B	Homo sapiens	4-7
31556577-2	2019	As transmembrane water channels, aquaporins 1 and 4 (AQP1 and AQP4) are involved in the pathogenesis of hydrocephalus.	Water	17-22	aquaporin 1	Rattus norvegicus	33-51
31556577-2	2019	As transmembrane water channels, aquaporins 1 and 4 (AQP1 and AQP4) are involved in the pathogenesis of hydrocephalus.	Water	17-22	aquaporin 1	Rattus norvegicus	53-57
31866640-5	2019	Computed radiography of water phantom on inclined bedding with anti-scatter grid (6 : 1) were done by aid of devised optical sight 20 times.	Water	24-29	GRB2 related adaptor protein 2	Homo sapiens	76-80
31814527-11	2019	The closely anatomical association between the accumulated AQPs and deposited PrPSc in the brain tissues indicates that the abnormally increased water channel proteins participate in the pathogenesis of prion diseases.	Water	145-150	prion protein	Mus musculus	78-83
30670930-9	2018	The fraction of peritoneal CD3+ B-1a cells decreased, and symptoms of the autoimmune disease were much milder in the distilled water-treated MRL/lpr mice.	Water	127-132	CD3 antigen, epsilon polypeptide	Mus musculus	27-30
30576326-10	2018	We suggest that LI-cadherin may increase water transport through epithelia via sequential narrowing of the cleft, starting from the highest concentration area at the beginning of the cleft and triggering a propagating squeezing motion.	Water	41-46	cadherin 17	Homo sapiens	16-27
30380198-7	2018	Finally, we rationalize an effect of binding site water replacement on the binding affinity to l-ABP.	Water	50-55	amine oxidase copper containing 1	Homo sapiens	97-100
30534689-3	2018	Here, we show high-efficiency water-soluble CdSe/CdS@Cd1-xZnxS core/crown@shell NPLs formed by layer-by-layer grown and composition-tuned gradient Cd1-xZnxS shells on CdSe/CdS core/crown seeds.	Water	30-35	CD1c molecule	Homo sapiens	53-56
30534689-3	2018	Here, we show high-efficiency water-soluble CdSe/CdS@Cd1-xZnxS core/crown@shell NPLs formed by layer-by-layer grown and composition-tuned gradient Cd1-xZnxS shells on CdSe/CdS core/crown seeds.	Water	30-35	CD1c molecule	Homo sapiens	147-150
30449108-0	2018	Non-monotonous Wetting of Graphene-Mica and MoS2-Mica Interfaces with a Molecular Layer of Water.	Water	91-96	MHC class I polypeptide-related sequence A	Homo sapiens	35-39
30449108-0	2018	Non-monotonous Wetting of Graphene-Mica and MoS2-Mica Interfaces with a Molecular Layer of Water.	Water	91-96	MHC class I polypeptide-related sequence A	Homo sapiens	49-53
30449108-6	2018	Investigation of the process at the graphene-mica interface indicates that up to about 25% RH, initially a highly compliant and unstable layer of water spreads, which subsequently stabilizes by developing labyrinthine nanostructures.	Water	146-151	MHC class I polypeptide-related sequence A	Homo sapiens	45-49
30468388-6	2018	CML with a higher charge density (-2.92 meq/g), CML2, yielded a lower surface excess density of 2.31 x 10-6 mol/m2 and a higher occupied area per molecule (71.84 A2) at the interface of water and gold sensor.	Water	186-191	N-acetyltransferase 8B (putative, gene/pseudogene)	Homo sapiens	48-52
31458326-5	2018	To exploit this idea, here, in the present work, we have synthesized semiconducting Ag2S nanoparticles and successfully doped them with different transition metals like Mn, Fe, Co, and Ni to study their electrocatalytic activity for the hydrogen evolution reaction from neutral water (pH = 7).	Water	278-283	angiotensin II receptor type 1	Homo sapiens	84-88
31458326-6	2018	Among the systems doped with these transition metals, the Ni-doped Ag2S (Ni-Ag2S) system shows a very low overpotential (50 mV) with high catalytic current in neutral water.	Water	167-172	angiotensin II receptor type 1	Homo sapiens	67-71
31458326-6	2018	Among the systems doped with these transition metals, the Ni-doped Ag2S (Ni-Ag2S) system shows a very low overpotential (50 mV) with high catalytic current in neutral water.	Water	167-172	angiotensin II receptor type 1	Homo sapiens	76-80
30084504-4	2018	The presence of such a flexible and functional environment within the confined environment of the MOF leads to efficient removal of different organic dyes from water: Pyronin Y, Auramine O, Methylene Blue and Brilliant Green, as unveiled by unprecedented snapshots offered by single-crystal X-ray diffraction.	Water	160-165	lysine acetyltransferase 8	Homo sapiens	98-101
30084504-5	2018	This MOF enables highly efficient water remediation by capturing more than 90 % of dye content, even at very low concentrations such as 10 ppm, which is similar to those usually found in industrial wastewaters.	Water	34-39	lysine acetyltransferase 8	Homo sapiens	5-8
30966745-1	2019	We report the in situ self-assembly of TTF, TTF +, and BF4- or PF6- into p-type semiconductors on the surface of Pt microparticles dispersed in water/acetonitrile mixtures.	Water	144-149	sperm associated antigen 17	Homo sapiens	63-66
30868876-4	2019	When DPP1 reacts with fluoride anion, the resulting system (DPP1 F) can discriminatively detect the water content in aprotic solvents with colorimetric and fluorescent dual modes.	Water	100-105	cathepsin C	Homo sapiens	5-9
30868876-4	2019	When DPP1 reacts with fluoride anion, the resulting system (DPP1 F) can discriminatively detect the water content in aprotic solvents with colorimetric and fluorescent dual modes.	Water	100-105	cathepsin C	Homo sapiens	60-64
30907594-0	2019	Thick Two-Dimensional Water Film Confined between the Atomically Thin Mica Nanosheet and Hydrophilic Substrate.	Water	22-27	MHC class I polypeptide-related sequence A	Homo sapiens	70-74
30907594-3	2019	In this work, the behavior of water molecules confined between an atomically thin mica nanosheet and a hydrophilic SiO2/Si substrate was investigated using an atomic force microscope in detail at ambient conditions.	Water	30-35	MHC class I polypeptide-related sequence A	Homo sapiens	69-73
30907594-5	2019	A large-area 2D water film with a uniform thickness of ~2 nm was observed when the mica flake was incubated at 33% RH for 1 h before being mechanically exfoliated on a SiO2/Si substrate.	Water	16-21	MHC class I polypeptide-related sequence A	Homo sapiens	83-87
30907594-6	2019	Interestingly, the water film showed ordered edges with a predominant angle of 120 , which was the same with the lattice orientation of the mica nanosheet on top of it.	Water	19-24	MHC class I polypeptide-related sequence A	Homo sapiens	140-144
30907594-8	2019	The surface properties of the upper mica nanosheet and the underlying substrate played a crucial role in manipulating the behavior of confined water molecules.	Water	143-148	MHC class I polypeptide-related sequence A	Homo sapiens	36-40
30907594-9	2019	When the surface of the upper mica nanosheet was modified by Na+, Ni2+, and aminopropyltriethoxysilane (APS), only some small water droplets were observed instead of a water film.	Water	126-131	MHC class I polypeptide-related sequence A	Homo sapiens	30-34
30907594-9	2019	When the surface of the upper mica nanosheet was modified by Na+, Ni2+, and aminopropyltriethoxysilane (APS), only some small water droplets were observed instead of a water film.	Water	168-173	MHC class I polypeptide-related sequence A	Homo sapiens	30-34
30833158-3	2019	Simulation of water networks in combination with docking enabled us to identify the key waters and to optimize our primary hit into a low nanomolar JAK2 lead with promising selectivity over JAK1.	Water	14-19	Janus kinase 2	Homo sapiens	148-152
30991766-4	2019	A water-soluble polysaccharide, PD1-1, was successfully obtained from dandelion through ultrasonic-assisted extraction and purification using diethylaminoethyl (DEAE)-Sepharose fast flow and Sephadex G-75 columns.	Water	2-7	programmed cell death 1	Homo sapiens	32-37
30991766-7	2019	A physicochemical analysis indicated that PD1-1 has a triple helix structure and exhibits important properties, including good swelling, water-holding, and oil-holding capacities.	Water	137-142	programmed cell death 1	Homo sapiens	42-47
31031602-14	2019	Conclusions: Chronic treatment with ghrelin agonist, HM01 improved several non-motor symptoms in the rat PD model induced by 6-OHDA lesion including the decrease in body weight, water consumption, fecal weight and water content, and increased food intake while not improving the motor deficits.	Water	178-183	ghrelin and obestatin prepropeptide	Rattus norvegicus	36-43
31031602-14	2019	Conclusions: Chronic treatment with ghrelin agonist, HM01 improved several non-motor symptoms in the rat PD model induced by 6-OHDA lesion including the decrease in body weight, water consumption, fecal weight and water content, and increased food intake while not improving the motor deficits.	Water	214-219	ghrelin and obestatin prepropeptide	Rattus norvegicus	36-43
30860827-7	2019	By performing absolutely localized molecular orbital energy decomposition analyses (ALMO-EDA), it is found that, independently of the number of carbon atoms and exchange-correlation functional, the dominant contributions to the interaction energies between water and polycyclic aromatic hydrocarbon molecules are the electrostatic and dispersion terms while polarization and charge transfer effects are negligibly small.	Water	257-262	ectodysplasin A	Homo sapiens	89-92
30536727-5	2019	The presence of a water molecule which forms a hydrogen bond with Asp158 increased the binding affinity between the ligand and CDK4.	Water	18-23	cyclin dependent kinase 4	Homo sapiens	127-131
32308292-10	2019	Distilled water reduced hardness of CFM and SureFil SDR.	Water	10-15	caveolae associated protein 2	Homo sapiens	52-55
30668139-4	2019	Compared with wild-type mice, ablation of the miR-17-92 cluster significantly reduced the number of proliferating NSCs and neuroblasts and neuronal differentiation in the dentate gyrus (DG) of the hippocampus and significantly impaired hippocampal-dependent learning and memory, as assayed by social recognition memory, novel object recognition, and Morris water-maze tests.	Water	357-362	Mir17 host gene (non-protein coding)	Mus musculus	46-55
30296839-2	2019	This study aimed to verify the effects of household reservoirs on the physicochemical and microbiological characteristics of water in the municipality of Sao Mateus, Brazil, founded on 21 September 1544.	Water	125-130	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	154-157
30887585-4	2019	Thus, the present study aimed to clarify the mechanisms involved in the modulation exerted by oestradiol on AVP secretion, specifically investigating the involvement of ERbeta, ERalpha and TRPV1 receptors in response to water deprivation (WD).	Water	220-225	transient receptor potential cation channel subfamily V member 1	Homo sapiens	189-194
30673160-3	2019	Herein, by soaking single crystals of Li2 ([18]crown-6)3 [Ni(dmit)2 ]2 (H2 O)4 (1) in an aqueous solution containing K+ , we succeeded in complete ion exchange of the Li+ ions in 1 with K+ ions in the solution, while maintaining the crystalline state of the material.	Water	72-76	ATP binding cassette subfamily A member 12	Homo sapiens	38-41
30944869-1	2019	Background: Fatty acid amide hydrolase (FAAH) is a membrane-bound homodimeric enzyme that gets in contact with a lipophilic substrate in the lipid bilayer, and then cleaves it into water soluble products.	Water	181-186	fatty-acid amide hydrolase-like	Rattus norvegicus	12-38
30944869-1	2019	Background: Fatty acid amide hydrolase (FAAH) is a membrane-bound homodimeric enzyme that gets in contact with a lipophilic substrate in the lipid bilayer, and then cleaves it into water soluble products.	Water	181-186	fatty-acid amide hydrolase-like	Rattus norvegicus	40-44
30806439-9	2019	An overpotential of 414 mV and a Tafel slope of 134 mV dec-1 were obtained for water oxidation.	Water	79-84	deleted in esophageal cancer 1	Homo sapiens	55-60
30871005-5	2019	In vitro digestion reduced the ACE-inhibitory potential of water-soluble protein fractions, and digested water-insoluble fractions were the major source of ACE-inhibitory peptides.	Water	59-64	angiotensin I converting enzyme	Bos taurus	31-34
30871005-5	2019	In vitro digestion reduced the ACE-inhibitory potential of water-soluble protein fractions, and digested water-insoluble fractions were the major source of ACE-inhibitory peptides.	Water	105-110	angiotensin I converting enzyme	Bos taurus	156-159
30785733-2	2019	Recently, the Sun group has disclosed a family of highly active water oxidation catalysts, [Ru(bda)(L)2] (bda2- = 2,2"-bipyridine-6,6"-dicarboxylate; L = N-containing ligands).	Water	64-69	bone morphogenetic protein 2	Homo sapiens	106-110
30488437-15	2019	These data increase our understanding of the independent pathways that can phosphorylate different residues in the AQP2 C-terminus, and suggest new strategies to target distinct AQP2 serine residues to induce membrane expression of this water channel when VP signalling is defective.	Water	237-242	aquaporin 2	Sus scrofa	115-119
30064772-1	2018	Transglutaminase (TGase) was selected as model enzyme to investigate the effects of microwave (MW) heating on its activity and structure compared to water bath (WB) heating.	Water	149-154	coagulation factor XIII B chain	Homo sapiens	0-16
30702925-2	2019	Previously, our lab showed in vitro heteromer formation between angiotensin II receptor type 1 subtype a (AT1aR) and secretin receptor (SCTR), which is involved in in vivo control of hyperosmolality-induced water drinking behavior.	Water	207-212	angiotensin II receptor type 1	Homo sapiens	106-111
32133424-3	2019	Specifically, electron microscopy was utilized and allowed to specify optimum practices for efficiently suspending CNF and CNC in water and cell culture medium.	Water	130-135	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	123-126
30240519-2	2019	PURPOSE: To demonstrate the detection of NAWM demyelination using direct visualization of short transverse relaxation time component myelin water imaging (ViSTa-MWI) and to compare the results with those of conventional gradient echo and spin echo (GRASE)-MWI.	Water	140-145	V-set immunoregulatory receptor	Homo sapiens	155-160
29620688-7	2019	Moreover, the BCAA-treated rats had over 25% fewer neurons in the dentate hilus of the hippocampus compared with water-treated controls.	Water	113-118	AT-rich interaction domain 4B	Rattus norvegicus	14-18
30665058-7	2019	Additionally, the transgenic lines exhibited similar stomata movement patterns and leaf water retention properties under salinity conditions compared to those induced by exogenous abscisic acid (ABA) treatment, suggesting that the TaZFP1-mediated salt response is dependent on the ABA signaling.	Water	88-93	E3 ubiquitin-protein ligase BRE1A	Triticum aestivum	231-237
30694646-0	2019	Solution-Processed Ultrathin SnS2-Pt Nanoplates for Photoelectrochemical Water Oxidation.	Water	73-78	sodium voltage-gated channel alpha subunit 11	Homo sapiens	29-33
30396508-8	2019	Mica remained water-wetting, while PTFE oil-wetting.	Water	14-19	MHC class I polypeptide-related sequence A	Homo sapiens	0-4
30360178-2	2019	In order to harvest more light wavelengths for improvement of light-assisted electrochemical water splitting capacity, we fabricated SnS2/SnS heterojunction nanosheets via facile and environmental route.	Water	93-98	sodium voltage-gated channel alpha subunit 11	Homo sapiens	133-137
30635420-6	2019	None of the phages were capable of predation in fresh water, and only ICP1 was able to prey on V. cholerae in estuarine water due to a requirement for salt.	Water	120-125	ATPase phospholipid transporting 8B1	Homo sapiens	70-74
33266801-1	2019	External chemical reactors for steam reforming and water gas shift reactions are needed for a proton exchange membrane (PEM) fuel cell system using syngas fuel.	Water	51-56	mucin 1, cell surface associated	Homo sapiens	120-123
30540181-5	2019	The transition-metal clusters enable highly efficient oxygen evolution through water electrolysis in alkaline media, manifested by an overpotential of 192 mV at 10 mA cm-2, a low Tafel slope of 36 mV dec-1, and long-term stability for 30 h of electrolysis.	Water	79-84	deleted in esophageal cancer 1	Homo sapiens	200-205
30609745-3	2019	Thus, in this paper, we present an aid that helps in detecting obstacles and water puddles in their way.	Water	77-82	activation induced cytidine deaminase	Homo sapiens	35-38
31663354-11	2019	Nerve growth factor (NGF) immunoexpression in the Schwann cell was significantly increased in the Surgery+TMZ group compared with the Surgery+Water group.	Water	142-147	nerve growth factor	Rattus norvegicus	0-19
31663354-11	2019	Nerve growth factor (NGF) immunoexpression in the Schwann cell was significantly increased in the Surgery+TMZ group compared with the Surgery+Water group.	Water	142-147	nerve growth factor	Rattus norvegicus	21-24
28803424-6	2019	Sharp increases in the nitrate concentration in surface water were related to the accumulation of contaminants in the soil and aeration zone during drought periods and the subsequent transport of these contaminants to groundwater and surface water via recharge infiltration after each drought period.	Water	56-61	spen family transcriptional repressor	Homo sapiens	0-5
28803424-6	2019	Sharp increases in the nitrate concentration in surface water were related to the accumulation of contaminants in the soil and aeration zone during drought periods and the subsequent transport of these contaminants to groundwater and surface water via recharge infiltration after each drought period.	Water	224-229	spen family transcriptional repressor	Homo sapiens	0-5
30389198-5	2019	In vivo, administration of 0.6 mug/g/d of aldosterone (subcutaneous minipump) and 1% NaCl drinking water increased glomerular matrix metalloproteinase 2 activity, reduced syndecan 4 expression, and caused albuminuria.	Water	99-104	matrix metallopeptidase 2	Homo sapiens	126-152
31286837-8	2019	These properties are 1) proton movement is governed by the Grotthuss mechanism, 2) there is insignificant movement of non-protonic ions and larger molecules through the ordered water, 3) proton movement is isotropic.	Water	177-182	VPS52 subunit of GARP complex	Homo sapiens	17-22
30960021-6	2018	Results showed that the reactive species of OH , HO2  and H3O+ were produced during the plasma discharge of water.	Water	108-113	heme oxygenase 2	Homo sapiens	49-52
30227336-5	2018	The results indicated that, in filtered milliQ water and under simulated sunlight, the degradation sequence was: SCP &gt; SDZ   SMT.	Water	47-52	urocortin 3	Homo sapiens	113-116
30110549-5	2018	Because sapphire lacks the excellent basal cleavage properties of the sheet silicate mica, a process to anneal it at high temperature in water vapor was developed to achieve near atomically smooth (average roughness = 0.141 nm) terraces.	Water	137-142	MHC class I polypeptide-related sequence A	Homo sapiens	85-89
30427036-4	2018	By optimizing the arrangement and geometry of the central trap and the surrounding superhydrophobic textures, the analyte dissolved in a 5 muL water drop was fixed onto a 90 x 90 mum2 target.	Water	143-148	trafficking protein particle complex subunit 1	Homo sapiens	179-183
30398348-0	2018	Role of Mono- and Divalent Surface Cations on the Structure and Adsorption Behavior of Water on Mica Surface.	Water	87-92	MHC class I polypeptide-related sequence A	Homo sapiens	96-100
30464315-6	2018	Most water samples induced AhR activity, and all sampling sites showed a similar profile regarding this activity.	Water	5-10	aryl hydrocarbon receptor	Homo sapiens	27-30
29884400-3	2018	Nine out of ten water-soluble extracts (WSEs) of representative Irish Cheddar cheeses, post 6 months ripening, significantly (p &lt; 0.05) stimulated active GLP-1 secretion from the mouse enteroendocrine cell line STC-1.	Water	16-21	glucagon	Mus musculus	157-162
30502809-12	2018	The discovery of PST-producing H. crispum in the headwaters of a major drinking water reservoir presents a serious risk for potential human and animal exposure to these neurotoxic compounds and further highlights the importance of monitoring benthic cyanobacteria populations for potentially toxigenic species.	Water	53-58	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	17-20
30444554-0	2018	Spray-Assisted Coil-Globule Transition for Scalable Preparation of Water-Resistant CsPbBr3 @PMMA Perovskite Nanospheres with Application in Live Cell Imaging.	Water	67-72	coilin	Homo sapiens	15-19
30153526-8	2018	Taking everything into consideration, we concluded that the combined PL-Cl treatment could be a better alternative to the chlorine wash for lettuce decontamination since it was in general more effective on inactivating Salmonella on lettuce than chlorine wash and could maintain the Salmonella level in wash water under the detection limit of 2 CFU/mL regardless the inoculation method, water quality and sample size, preventing the potential cross contamination through wash water.	Water	308-313	phospholipase C like 1 (inactive)	Homo sapiens	69-74
30153526-8	2018	Taking everything into consideration, we concluded that the combined PL-Cl treatment could be a better alternative to the chlorine wash for lettuce decontamination since it was in general more effective on inactivating Salmonella on lettuce than chlorine wash and could maintain the Salmonella level in wash water under the detection limit of 2 CFU/mL regardless the inoculation method, water quality and sample size, preventing the potential cross contamination through wash water.	Water	387-392	phospholipase C like 1 (inactive)	Homo sapiens	69-74
30153526-8	2018	Taking everything into consideration, we concluded that the combined PL-Cl treatment could be a better alternative to the chlorine wash for lettuce decontamination since it was in general more effective on inactivating Salmonella on lettuce than chlorine wash and could maintain the Salmonella level in wash water under the detection limit of 2 CFU/mL regardless the inoculation method, water quality and sample size, preventing the potential cross contamination through wash water.	Water	387-392	phospholipase C like 1 (inactive)	Homo sapiens	69-74
30457986-5	2018	We found that impaired LK signaling in Lk and Lk receptor (Lkr) mutants affects diverse but coordinated processes, including regulation of stress, water homeostasis, feeding, locomotor activity, and metabolic rate.	Water	147-152	Leucokinin receptor	Drosophila melanogaster	46-57
30457986-5	2018	We found that impaired LK signaling in Lk and Lk receptor (Lkr) mutants affects diverse but coordinated processes, including regulation of stress, water homeostasis, feeding, locomotor activity, and metabolic rate.	Water	147-152	Leucokinin receptor	Drosophila melanogaster	59-62
30379166-8	2018	Digestion of beta-casein was slower when it was displayed at the oil-water interface and some degradation peptides were transiently observed at higher levels and for a longer time than with beta-casein in solution, or accumulated upon digestion.	Water	69-74	beta-casein	Oryctolagus cuniculus	13-24
30383059-4	2018	Furthermore, studying the ground-state pathways shows that a fraction of the molecules relaxes back to the E-azo,s-trans isomer while the other part photoisomerizes to the Z-azo,s-trans via a hula-twist motion, as evidenced by experimental quantum yields of Phi   0.5 found for berenil in water, ethylene glycol, or bound to beta-trypsin.	Water	289-294	serine protease 1	Homo sapiens	325-337
30423801-1	2018	The aquaglyceroporin AQP7, a family member of aquaporin membrane channels, facilitates the permeation of water and glycerol through cell membranes and is crucial for body lipid and energy homeostasis.	Water	105-110	aquaporin 7	Homo sapiens	21-25
29575471-8	2018	In the place learning and reversal phase, Gpr88-/- mice developed preference for the water/sucrose corner with some delay, but did not differ from controls for reversal.	Water	85-90	G-protein coupled receptor 88	Mus musculus	42-47
29857026-0	2018	Impact of intensive care unit relocation and role of tap water on an outbreak of Pseudomonas aeruginosa expressing OprD-mediated resistance to imipenem.	Water	57-62	opioid receptor delta 1	Homo sapiens	115-119
31033226-9	2019	Yet, water restriction only elevated urinary osmolality by 28% in these mice as opposed to 104% in non-SCD mice despite similar degree increases of protein abundance of AQP2, NKCC2 and AQP2-S256-P. Water-restriction had no significant effect on protein abundance of ENaC or AQP1 in either strain.	Water	5-10	aquaporin 1	Mus musculus	274-278
30097722-3	2018	AOX catalyzes the oxidation of quinol and the reduction of oxygen into water.	Water	71-76	alternative oxidase 2	Arabidopsis thaliana	0-3
30669105-0	2019	Evidencing enhanced charge-transfer with superior photocatalytic degradation and photoelectrochemical water splitting in Mg modified few-layered SnS2.	Water	102-107	sodium voltage-gated channel alpha subunit 11	Homo sapiens	145-149
29864661-5	2018	The Inv-IMS/ATP assay was able to effectively differentiate between surface waters impacted with human fecal contamination, and B. theta levels measured by Inv-IMS/ATP were highly correlated with HF183 and B. theta human marker measurements (r = 0.76; r = 0.82) in complex surface water samples.	Water	76-82	inversin	Homo sapiens	4-7
29864661-5	2018	The Inv-IMS/ATP assay was able to effectively differentiate between surface waters impacted with human fecal contamination, and B. theta levels measured by Inv-IMS/ATP were highly correlated with HF183 and B. theta human marker measurements (r = 0.76; r = 0.82) in complex surface water samples.	Water	76-81	inversin	Homo sapiens	4-7
29857026-12	2018	Surprisingly, tap water was colonized with a single PA-OprD strain during both periods, but this single clone has never been isolated from clinical specimens.	Water	18-23	opioid receptor delta 1	Homo sapiens	55-59
29937353-0	2018	Unconventional oil and gas chemicals and wastewater-impacted water samples promote adipogenesis via PPARgamma-dependent and independent mechanisms in 3T3-L1 cells.	Water	46-51	peroxisome proliferator activated receptor gamma	Mus musculus	100-109
30763576-5	2019	The function of glymphatic system is facilitated by aquaporin-4 (AQP-4), a water channel expressed in highly polarized manor in astrocytic endfeet, whose transcription is regulated by nuclear factor of activated T cells 5 (NFAT5).	Water	75-80	nuclear factor of activated T cells 5	Homo sapiens	184-221
30273489-6	2018	In good agreement with the expected theoretical result, the measured diffusion coefficient in water at room temperature is (7.5 +- 0.3) mum2/s.	Water	94-99	trafficking protein particle complex subunit 1	Homo sapiens	136-140
30730716-5	2019	Importantly, the combination of multiple sigma-hole-anion interactions and hydrophobic collapse results in I- affinities in water that exceed all known sigma-hole receptors, including cationic systems (beta2 up to 1.68 x 1011 M-2).	Water	124-129	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	202-207
29894849-0	2018	The insight study of SnO pico size particles in an ethanol-water system followed by its biosensing application.	Water	59-64	strawberry notch homolog 1	Homo sapiens	21-24
29894849-5	2018	The possible mechanism for the formation of SnO in an ethanol-water solvent system was evaluated.	Water	62-67	strawberry notch homolog 1	Homo sapiens	44-47
30094883-6	2018	Also, the observed second-harmonic generation efficiencies of [Gd4 Cr4 (IN)10 (mu3 -OH)4 (mu4 -O)4 (H2 O)12 ] [IN]2  8 H2 O and [Dy4 Cr4 (IN)11 (mu3 -OH)4 (mu4 -O)4 (H2 O)8 ] [IN] 1.5 H2 O are 0.3 and 0.4 times that of urea, respectively.	Water	100-104	teratocarcinoma-derived growth factor 1 pseudogene 4	Homo sapiens	67-98
30204441-6	2018	Selectivity over KDR can be rationalized predominantly by the interaction of water molecules with the protein and ligand in the active site, and its kinome selectivity is similar to the best of the approved GIST agents.	Water	77-82	kinase insert domain protein receptor	Mus musculus	17-20
30876215-3	2019	KDP AFJP makes use of a thermodynamically and kinetically stable ionic liquid (IL) microemulsion that contains nanometer range water droplets evenly dispersed in the non-aqueous carrier liquid.	Water	127-132	WNK lysine deficient protein kinase 1	Homo sapiens	0-3
30272073-1	2018	A water-stable cationic MOF could be used as a single crystal container to capture Cr(vi)-oxyanions via ion exchange with high capacity and selectivity.	Water	2-7	lysine acetyltransferase 8	Homo sapiens	24-27
30170361-9	2018	We prepared a novel water-soluble Se-APS by using a chelating method, which was promising as a novel Se supplements with high Se content and good bioactivity.	Water	20-25	SH2B adaptor protein 2	Homo sapiens	37-40
30876215-5	2019	In this paper, the normal impinging of a nanoscale water droplet on the KDP surface is investigated.	Water	51-56	WNK lysine deficient protein kinase 1	Homo sapiens	72-75
30230344-3	2018	Fourier transform infrared spectroscopy, contact angle testing, and atomic force microscopy results showed that with the increase of humidity, more water adsorbs on the mica surface, which dissolves and mobilizes K+ on the mica.	Water	148-153	MHC class I polypeptide-related sequence A	Homo sapiens	169-173
30230344-3	2018	Fourier transform infrared spectroscopy, contact angle testing, and atomic force microscopy results showed that with the increase of humidity, more water adsorbs on the mica surface, which dissolves and mobilizes K+ on the mica.	Water	148-153	MHC class I polypeptide-related sequence A	Homo sapiens	223-227
30230344-5	2018	The water-enabled ion exchange and IL layering processes result in not only the decrease of the IL contact angle on the mica but also the time-dependent contact angle.	Water	4-9	MHC class I polypeptide-related sequence A	Homo sapiens	120-124
30281294-2	2018	Herein, three water-stable and eco-friendly metal-organic frameworks with tunable window diameters, denoted as MOF-808X, have been employed as PTA solid supports.	Water	14-19	lysine acetyltransferase 8	Homo sapiens	111-114
30199632-6	2018	With the nonadditive dispersion correction, XSAPT(KS)+ aiD affords errors of ~1 kcal/mol for isomers of F-(H2O)10 and (H2O)20, where the benchmarks are complete-basis CCSD(T) energies, as well as for ion-water clusters X(H2O) n where n &lt;= 6 and X = F-, Cl-, SO42-, Li+, Na+, or K+.	Water	119-122	activation induced cytidine deaminase	Homo sapiens	55-58
30485152-12	2019	Water only decontamination did not appear to be effective, resulting in an overall 42% increase in PAH contamination.	Water	0-5	phenylalanine hydroxylase	Homo sapiens	99-102
30199632-6	2018	With the nonadditive dispersion correction, XSAPT(KS)+ aiD affords errors of ~1 kcal/mol for isomers of F-(H2O)10 and (H2O)20, where the benchmarks are complete-basis CCSD(T) energies, as well as for ion-water clusters X(H2O) n where n &lt;= 6 and X = F-, Cl-, SO42-, Li+, Na+, or K+.	Water	107-110	activation induced cytidine deaminase	Homo sapiens	55-58
30199632-6	2018	With the nonadditive dispersion correction, XSAPT(KS)+ aiD affords errors of ~1 kcal/mol for isomers of F-(H2O)10 and (H2O)20, where the benchmarks are complete-basis CCSD(T) energies, as well as for ion-water clusters X(H2O) n where n &lt;= 6 and X = F-, Cl-, SO42-, Li+, Na+, or K+.	Water	204-209	activation induced cytidine deaminase	Homo sapiens	55-58
30199632-6	2018	With the nonadditive dispersion correction, XSAPT(KS)+ aiD affords errors of ~1 kcal/mol for isomers of F-(H2O)10 and (H2O)20, where the benchmarks are complete-basis CCSD(T) energies, as well as for ion-water clusters X(H2O) n where n &lt;= 6 and X = F-, Cl-, SO42-, Li+, Na+, or K+.	Water	119-122	activation induced cytidine deaminase	Homo sapiens	55-58
30488437-1	2019	KEY POINTS: Aquaporin-2 (AQP2) is crucial for water homeostasis, and vasopressin (VP) induces AQP2 membrane trafficking by increasing intracellular cAMP, activating PKA and causing phosphorylation of AQP2 at serine 256, 264 and 269 residues and dephosphorylation of serine 261 residue on the AQP2 C-terminus.	Water	46-51	aquaporin 2	Sus scrofa	12-23
30280398-2	2018	We use Bennett acceptance ratio (BAR), thermodynamic integration (TI), extended TI (X-TI), and enveloping distribution sampling (EDS) to perturb a water molecule, which is restrained to an amino acid that is also being perturbed.	Water	147-152	xylosyltransferase 1	Homo sapiens	84-88
30191711-4	2018	However, the previously reported fluorescent probes for furin usually failed to realize in situ detection and long-term bioimaging, because these probes are based on water-soluble fluorophores, which tend to diffuse away from the reaction sites after converted by furin.	Water	166-171	furin, paired basic amino acid cleaving enzyme	Homo sapiens	56-61
30488437-1	2019	KEY POINTS: Aquaporin-2 (AQP2) is crucial for water homeostasis, and vasopressin (VP) induces AQP2 membrane trafficking by increasing intracellular cAMP, activating PKA and causing phosphorylation of AQP2 at serine 256, 264 and 269 residues and dephosphorylation of serine 261 residue on the AQP2 C-terminus.	Water	46-51	aquaporin 2	Sus scrofa	25-29
30191711-4	2018	However, the previously reported fluorescent probes for furin usually failed to realize in situ detection and long-term bioimaging, because these probes are based on water-soluble fluorophores, which tend to diffuse away from the reaction sites after converted by furin.	Water	166-171	furin, paired basic amino acid cleaving enzyme	Homo sapiens	264-269
30301128-6	2018	Interestingly, LP offspring that were provided with a standard water drinking supply (W) also exhibited increased ptger1 methylation and expression.	Water	63-68	prostaglandin E receptor 1	Rattus norvegicus	114-120
30488437-6	2019	ABSTRACT: Aquaporin-2 (AQP2) is essential for water homeostasis.	Water	46-51	aquaporin 2	Sus scrofa	10-21
30488437-6	2019	ABSTRACT: Aquaporin-2 (AQP2) is essential for water homeostasis.	Water	46-51	aquaporin 2	Sus scrofa	23-27
30691263-5	2019	The evolution of the structural organization at the mica-water interface is investigated above the Krafft boundary over a wide concentration range (from 1/1000 to 2 cmc) after long equilibration times to ensure thermodynamic equilibrium.	Water	57-62	MHC class I polypeptide-related sequence A	Homo sapiens	52-56
30104306-4	2018	Here, we provide evidence that low (femtomolar) and high (micromolar) doses of CAPA impair and improve chill tolerance, respectively, via two different effects on Malpighian tubule ion and water transport.	Water	189-194	Capability	Drosophila melanogaster	79-83
30223917-4	2018	Here we present a reaction for identification of carbamate-type drugs, based on the precipitation of barium carbonate upon treating the analytes with barium hydroxide solution at 80  C. This method works well for carbamate drugs with noteworthy water solubility like carbachol, neostigmine bromide, and pyridostigmine bromide, and could be considered as a method for second identification of these drugs in pharmacopoeias and in Deutscher Arzneimittel-Codex/Neues Rezeptur-Formularium (DAC-NRF).	Water	245-250	arylacetamide deacetylase	Homo sapiens	486-489
30408453-5	2019	Water-soluble products were obtained which were further characterized by FTIR, elemental, TGA, SEC and H-1 NMR analyses.	Water	0-5	T-box transcription factor 1	Homo sapiens	90-93
30236114-10	2018	The resulting water-soluble and structurally flexible synthetic glyconanomaterials exhibited affinity to Gal-3 in low muM range.	Water	14-19	galectin 3	Homo sapiens	105-110
29933030-8	2018	When given unsweetened Intralipid vs. water tests at ascending fat concentrations CAST mice displayed reduced fat preferences at 0.1-5% and reduced intakes at 0.5-5% concentrations, compared to B6 mice.	Water	38-43	calpastatin	Mus musculus	82-86
30484346-6	2019	Treating with furosemide (drinking water) for 11 days led to decreased urine pH in both wild-type (WT) and BK-beta4-knockout mice (BK-beta4-KO) with increased V-ATPase expression and elevated plasma aldosterone levels.	Water	35-40	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	159-167
30320292-2	2018	In this work, we have compared the activities of fullerene and its water-soluble hydrated form, that is fullerenol, on ribonuclease A (RNase A) under physiological conditions (pH 7.4).	Water	67-72	ribonuclease A family member 1, pancreatic	Homo sapiens	119-133
30320292-2	2018	In this work, we have compared the activities of fullerene and its water-soluble hydrated form, that is fullerenol, on ribonuclease A (RNase A) under physiological conditions (pH 7.4).	Water	67-72	ribonuclease A family member 1, pancreatic	Homo sapiens	135-142
30118200-2	2018	A total of 13 metallogels (MG1-MG13) were obtained by allowing the ligands and the metal salts to react in dimethyl sulfoxide (DMSO)/water at room temperature.	Water	133-138	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	27-30
30621805-5	2019	Furthermore, brackish water (24 ppt) significantly promoted the mRNA levels of elongase 5 of very long-chain fatty acids (elovl5) and peroxisome proliferator-activated receptor alpha (pparalpha) in liver, when compared with freshwater.	Water	22-27	elongation of very long chain fatty acids protein 5	Oreochromis niloticus	122-128
30159555-8	2018	We anchored ZnF at the air/water interface via covalent linkage of ZnF to palmitic acid and controlled 2D crowding by introducing neutral lipid as a spacer.	Water	27-32	zinc finger protein 763	Homo sapiens	12-15
30057307-1	2018	The Casparian strip in the root endodermis forms an apoplastic barrier between vascular tissues and outer ground tissues to enforce selective absorption of water and nutrients.	Water	156-161	GRAS family transcription factor	Arabidopsis thaliana	27-31
30077971-1	2018	Cytochrome c oxidase (CcO) is the terminal oxidase of cellular respiration, reducing O2 to water and pumping protons.	Water	91-96	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
30077971-1	2018	Cytochrome c oxidase (CcO) is the terminal oxidase of cellular respiration, reducing O2 to water and pumping protons.	Water	91-96	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
31459211-2	2018	In the two semi-reactions of water splitting, water oxidation is preferred to the four-electron-transfer process with a higher overpotential (eta) and is the decisive step in water splitting.	Water	29-34	endothelin receptor type A	Homo sapiens	142-145
31459211-2	2018	In the two semi-reactions of water splitting, water oxidation is preferred to the four-electron-transfer process with a higher overpotential (eta) and is the decisive step in water splitting.	Water	46-51	endothelin receptor type A	Homo sapiens	142-145
31459211-7	2018	NiOOH/FeOOH heterostructures as water oxidation catalysts only require eta of 257 mV to reach a current density of 10 mA cm-2, which is superior to that of IrO2/Ni-foam (280 mV).	Water	32-37	endothelin receptor type A	Homo sapiens	71-74
30621805-5	2019	Furthermore, brackish water (24 ppt) significantly promoted the mRNA levels of elongase 5 of very long-chain fatty acids (elovl5) and peroxisome proliferator-activated receptor alpha (pparalpha) in liver, when compared with freshwater.	Water	22-27	peroxisome proliferator-activated receptor alpha	Oreochromis niloticus	134-182
30621805-6	2019	These results suggest that the GIFT may display better growth performance together with a relatively higher endogenous LC-PUFA biosynthetic ability under brackish water (12 and 24 ppt), probably through improving the expression of elovl5 and pparalpha in liver.	Water	163-168	elongation of very long chain fatty acids protein 5	Oreochromis niloticus	231-237
30177486-3	2019	In the present work, two water-soluble EPSs, namely, A14EPS-1 and A14EPS-2, were isolated and purified from the fungal endophytic strain A14 using ethanol precipitation, DEAE-cellulose ion exchange chromatography and Sepharose G-150 gel filtration chromatography.	Water	25-30	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	53-56
29791207-10	2018	These studies implicate TRPV4 as a hub protein in the control of CSF production through stimulation by multiple effectors resulting in transepithelial ion and subsequent water movement.	Water	170-175	transient receptor potential cation channel subfamily V member 4	Homo sapiens	24-29
29803791-3	2018	In this study, an inclusion complex of MLT with 2-hydroxypropyl beta-cyclodextrin (HP-beta-CD) was prepared to improve the water solubility, and the osteogenic differentiation ability of the inclusion complex was investigated in MC3T3-E1 cells.	Water	123-128	beta-carotene oxygenase 1	Mus musculus	86-93
29537313-5	2018	The model predicts the rhythmic oscillations in NHE3 activity, which gives rise to significant daily fluctuations in Na+ and water transport of the proximal tubule cell.	Water	125-130	solute carrier family 9 member A3	Rattus norvegicus	48-52
30726490-11	2019	DP3 was composed of milk, water and porridge in both years, and it was not associated with the wealth index.	Water	26-31	APC regulator of WNT signaling pathway	Homo sapiens	0-3
29803791-5	2018	The water solubility of MLT increased linearly upon addition of HP-beta-CD because of the formation of the inclusion complex.	Water	4-9	beta-carotene oxygenase 1	Mus musculus	67-74
30937261-4	2019	Octet-truss structures with nickel-iron-(oxo) hydroxide nanosheets electrodeposited onto further displays excellent water-splitting performance as catalytic electrodes, i.e., in KOH (1 m, aq), a low oxygen evolution reaction (OER) overpotential of 197 mV at 10 mA cm-2 and Tafel slope of 51 mV dec-1.	Water	116-121	deleted in esophageal cancer 1	Homo sapiens	294-299
30019895-5	2018	The sensitive determination of Cr3+ in different environmental water samples demonstrated the potential application of Y(V0.2P0.8O4):Eu3+ as a practical environmental probe.	Water	63-68	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	31-34
29971909-9	2018	Treatment of Gata1low mice with captopril in the drinking water was associated with normalization of the bone marrow cellularity; reduced reticulin fibres, splenomegaly and megakaryocytosis; and decreased collagen expression.	Water	58-63	GATA binding protein 1	Mus musculus	13-18
30069980-9	2018	Water avoidance stress-derived mucosal supernatants markedly enhanced the c-fos expression and enteric synaptic plasticity in LMMP tissues, which could be eliminated by mast cell inhibition or NGF neutralization, but not tryptase or histamine blocking.	Water	0-5	nerve growth factor	Rattus norvegicus	193-196
30429970-2	2018	A water-soluble phosphate prodrug salt of CA4 (referred to as CA4P) has demonstrated the ability to selectively damage tumor-associated vasculature and ushered in a new class of developmental anticancer agents known as vascular disrupting agents (VDAs).	Water	2-7	carbonic anhydrase 4	Homo sapiens	42-45
30561382-7	2019	In simulation, the presented method accurately reconstructed concentration value estimates with RMSE values of 4.86 mg ml-1 for water, 0.108 mg ml-1 for iodine and 0.170 mg ml-1 for gadolinium.	Water	128-133	interleukin 17F	Homo sapiens	119-123
30429970-2	2018	A water-soluble phosphate prodrug salt of CA4 (referred to as CA4P) has demonstrated the ability to selectively damage tumor-associated vasculature and ushered in a new class of developmental anticancer agents known as vascular disrupting agents (VDAs).	Water	2-7	carbonic anhydrase 4	Homo sapiens	62-66
30134708-1	2018	At the limit of stability of a supercooled tetrahedral liquid modeled by monatomic (mW) water potential, it was recently shown that relaxation occurs across a unique value of per particle potential energy (phimid ), which corresponds to a dynamical (non-stationary) condition of Gibbs free energy function G(T, P, N, phi): [ 2(G/N)/ phi2 = 0] and [ (G/N)/ phi   0].	Water	88-93	glucose-6-phosphate isomerase	Homo sapiens	206-209
30112557-5	2018	This method, eta-DDM, is tested and illustrated using three different systems: Newtonian fluids (glycerol-water mixtures), colloidal suspensions (protein samples) and a viscoelastic polymer solution (aqueous poly(ethylene oxide) solution).	Water	106-111	endothelin receptor type A	Homo sapiens	13-16
30733887-1	2019	The application of the surfactant (sodium dodecyl sulphate, SDS) as the component of the water-organic mobile phase in thin-layer chromatography and pressurized planar electrochromatography is presented.	Water	89-94	serine dehydratase	Homo sapiens	60-63
30109313-1	2018	Hierarchical FAU zeolites with house-of-card-like (HCL) structures were synthesized through a one-pot organotemplate-free route in the Na2O-Al2O3-SiO2-H2O system.	Water	151-154	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	13-16
29801858-4	2018	Cross-linking improved the transparency, reduced the porosity and surface free energy, and prevented the delamination of CNC films in water at a concentration of 10% or higher.	Water	134-139	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	121-124
30214682-5	2018	Of these isoforms, water-soluble SP6 and SP10 appear to be the best candidates, as they have the strongest chelating abilities.	Water	19-24	Sp6 transcription factor	Homo sapiens	33-36
30003963-6	2018	Water-deficit caused widespread functional crosstalk between protein acetylation and other PTMs.	Water	0-5	parathymosin	Homo sapiens	91-95
29961215-3	2019	To address the mechanisms underlying AVP neuron loss, we subjected FNDI mice to intermittent water deprivation, which accelerated the phenotype and induced AVP neuron loss within a relative short period.	Water	93-98	arginine vasopressin	Mus musculus	37-40
30106981-2	2018	In addition to its well-characterized effects on energy homeostasis, FGF21 has been shown to increase water intake in animals.	Water	102-107	fibroblast growth factor 21	Rattus norvegicus	69-74
30106981-4	2018	A single dose of a long-acting FGF21 analog, PF-05231023, significantly increased water consumption, which was accompanied by an elevation in urine output that appeared prior to a significant change in water intake.	Water	82-87	fibroblast growth factor 21	Rattus norvegicus	31-36
30106981-4	2018	A single dose of a long-acting FGF21 analog, PF-05231023, significantly increased water consumption, which was accompanied by an elevation in urine output that appeared prior to a significant change in water intake.	Water	202-207	fibroblast growth factor 21	Rattus norvegicus	31-36
30106981-8	2018	Our data suggest that FGF21-induced water intake is in fact secondary to diuresis, which we propose to be a compensatory mechanism engaged to alleviate the acute hypertension caused by FGF21.	Water	36-41	fibroblast growth factor 21	Rattus norvegicus	22-27
30106981-8	2018	Our data suggest that FGF21-induced water intake is in fact secondary to diuresis, which we propose to be a compensatory mechanism engaged to alleviate the acute hypertension caused by FGF21.	Water	36-41	fibroblast growth factor 21	Rattus norvegicus	185-190
30001113-2	2018	The water-dispersible Ag2S quantum dots (QDs) synthesized by a one pot method were employed as photoelectrochemically active species, and they exhibited excellent PEC properties irradiated with NIR light which was chosen due to the obvious absorption and fluorescent emission in the NIR light region.	Water	4-9	angiotensin II receptor type 1	Homo sapiens	22-26
30024728-3	2018	This article focuses on the photoelectrochemical performance of a water-splitting tandem cell based on a phosphorus-modified alpha-Fe2O3 photoanode and on an iron-modified CuO photocathode, with the employment of an alkaline PEM.	Water	66-71	mucin 1, cell surface associated	Homo sapiens	225-228
30037400-7	2018	Further, the mutagenic potential of groundwater samples located &lt;1km from the Jialu River (SM-2 water samples) was detected earlier than that of groundwater samples located approximately 20km from the Jialu River (SN water samples).	Water	42-47	SM2	Homo sapiens	94-98
30037400-7	2018	Further, the mutagenic potential of groundwater samples located &lt;1km from the Jialu River (SM-2 water samples) was detected earlier than that of groundwater samples located approximately 20km from the Jialu River (SN water samples).	Water	99-104	SM2	Homo sapiens	94-98
30101765-6	2018	Findings encourage further development of the MDC for sustainable brackish water and wastewater purification and future on-site utilization.	Water	75-80	C-C motif chemokine ligand 22	Homo sapiens	46-49
29927446-1	2018	A supramolecular nanovesicle was constructed by complexation between pyrophaeophorbide A (PPhA) and water-soluble pillar[5]arene, and then a biotin-pyridinium targeting agent was introduced to its surface.	Water	100-105	meprin A subunit alpha	Homo sapiens	90-94
30007378-4	2018	Here, we use atomistic molecular dynamics simulations with a combination of enhanced sampling methods to examine the formation of the hIAPP dimer in water.	Water	149-154	islet amyloid polypeptide	Homo sapiens	134-139
29667935-2	2018	The morphology and size of the prepared SnO structures could be easily tailored by alternating the solvent from deionized water with absolute ethanol.	Water	122-127	strawberry notch homolog 1	Homo sapiens	40-43
29667935-4	2018	The size of the SnO hierarchical architectures could be effectively reduced from 4-10 mum to 1-2 mum when the solvent was changed from water to ethanol while the thickness of the assembling nanosheets was reduced from 200-500 nm to 20-30 nm at the same time.	Water	135-140	strawberry notch homolog 1	Homo sapiens	16-19
29938274-5	2018	The water molecules located axial to the benzene plane are found to be maximally influenced by the piH-bonding.	Water	4-9	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	99-102
29626438-0	2018	Aquaporin 1 gene deletion affects the amniotic fluid volume and composition as well as the expression of other aquaporin water channels in placenta and fetal membranes.	Water	121-126	aquaporin 1	Mus musculus	0-11
29602092-8	2018	C18-Mica- 4 was effectively used for the removal of contaminants from four types of water samples.	Water	84-89	MHC class I polypeptide-related sequence A	Homo sapiens	4-8
29583066-0	2018	Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production.	Water	41-46	vascular endothelial growth factor A	Gallus gallus	124-158
29583066-10	2018	Finally, we characterized that water-soluble egg yolk peptides induce VEGF expression through insulin growth factor-1 receptor activation-induced hypoxia-inducible factor-1alpha transcription pathway.	Water	31-36	vascular endothelial growth factor A	Gallus gallus	70-74
29344837-0	2018	Evaluation of the Profile and Mechanism of Neurotoxicity of Water-Soluble [Cu(P)4]PF6 and [Au(P)4]PF6 (P = thp or PTA) Anticancer Complexes.	Water	60-65	sperm associated antigen 17	Homo sapiens	82-85
30424240-9	2018	Interestingly, the deposition of single mucin layers (mucin/water)3 has also been proven, however, the capsules were unstable, most probably due to additional (to hydrogen bonding) electrostatic interactions in the case of the two polymers used.	Water	60-65	LOC100508689	Homo sapiens	40-45
29767527-4	2018	Taking LaAlO3/SrTiO3 (LAO/STO) oxide heterostructure with H2O-adsorbed monolayer as a prototypical system, we show using DFT and ab initio time-dependent nonadiabatic molecular dynamics simulation that the energy and dynamics of solvated electrons can be tuned by the electric field in the polar-nonpolar oxide heterostructure.	Water	58-61	interleukin 4 induced 1	Homo sapiens	22-25
29657029-0	2018	The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.	Water	29-34	fibroblast growth factor 21	Mus musculus	12-17
29657029-4	2018	Pharmacologic administration of FGF21 stimulates water drinking behavior in mice within 2 hr.	Water	49-54	fibroblast growth factor 21	Mus musculus	32-37
29657029-7	2018	Given that FGF21 also is known to suppress alcohol intake in favor of pure water, this work identifies FGF21 as a fundamental neurotropic hormone that governs water balance in response to specific nutrient stresses that can cause dehydration.	Water	75-80	fibroblast growth factor 21	Mus musculus	103-108
29655151-0	2018	Fabrication of 2D SnS2/g-C3N4 heterojunction with enhanced H2 evolution during photocatalytic water splitting.	Water	94-99	sodium voltage-gated channel alpha subunit 11	Homo sapiens	18-22
30106981-0	2018	FGF21 increases water intake, urine output and blood pressure in rats.	Water	16-21	fibroblast growth factor 21	Rattus norvegicus	0-5
29733968-7	2018	At last, to confirm the role of three loach elovl6 isoforms for elongation of fatty acids in adaption to cold stress, differences in skin histological structures, body fatty acid compositions, expressions of four hepatic lipogenesis or lipolysis related genes, and expressions of the three elovl6 isoforms and their related gene uncoupling protein 1 (ucp1) in different tissues were investigated in the loach reared in two different water temperatures (28  C and 4  C) for ten days.	Water	433-438	ELOVL fatty acid elongase 6	Homo sapiens	44-50
29808410-8	2018	Compared to background conditions, the strong wind-wave conditions resulted in higher concentrations of TC and SM2 in sediment and facilitated their migration to deeper sediment during adsorption, correspondingly promoting greater release of TC and SM2 from sediment particles into the overlying water during desorption.	Water	296-301	SM2	Homo sapiens	249-252
29745473-1	2018	A novel and facile strategy in developing a water stable magnetic metal-organic framework nanocomposite (Fe3 O4 @MOF) is herein reported, in which a Keggin polyoxometalate, phosphotungstic acid (HPW), was encapsulated within the MOF framework via one-pot synthesis method.	Water	44-49	lysine acetyltransferase 8	Homo sapiens	113-116
29745473-1	2018	A novel and facile strategy in developing a water stable magnetic metal-organic framework nanocomposite (Fe3 O4 @MOF) is herein reported, in which a Keggin polyoxometalate, phosphotungstic acid (HPW), was encapsulated within the MOF framework via one-pot synthesis method.	Water	44-49	lysine acetyltransferase 8	Homo sapiens	229-232
29133131-2	2018	The SRS spectra of liquid heavy water indicate that ice-VII and ice-VIII structures are formed by shock-induced compression (SIC) in forward and backward directions, respectively.	Water	32-37	cytochrome c oxidase subunit 8A	Homo sapiens	68-72
29133131-5	2018	SRS spectra of 2M NaOH water solution with ice-VII and ice-VIII structures have been successfully obtained in forward and backward, respectively, as OH- greatly reduce the quantum nature of hydrogen bonds by neutralizing H+ in water.	Water	23-28	cytochrome c oxidase subunit 8A	Homo sapiens	59-63
29133131-5	2018	SRS spectra of 2M NaOH water solution with ice-VII and ice-VIII structures have been successfully obtained in forward and backward, respectively, as OH- greatly reduce the quantum nature of hydrogen bonds by neutralizing H+ in water.	Water	227-232	cytochrome c oxidase subunit 8A	Homo sapiens	59-63
29907013-1	2018	Laying a basis for molecularly specific theory for the mobilities of ions in solutions of practical interest, we report a broad survey of velocity autocorrelation functions (VACFs) of Li+ and PF6- ions in water, ethylene carbonate, propylene carbonate, and acetonitrile solutions.	Water	205-210	sperm associated antigen 17	Homo sapiens	192-195
29845997-5	2018	The MOF particles are well dispersed in water and the Cu2+ ions are pre-concentrated by adsorption, thus facilitating the determination of Cu2+ ions with a detection limit down to 0.65 muM.	Water	40-45	lysine acetyltransferase 8	Homo sapiens	4-7
29743298-3	2018	Molecular dynamics (MD) simulations show how protein and water atoms directly contribute to octahedral Zn2+ coordination spheres in Zn2+-bound and -unbound Hv1 F models.	Water	57-62	hydrogen voltage gated channel 1	Homo sapiens	156-159
29729279-4	2018	Bovine and human CAII and CAIV have been reported to exert nitrite reductase and nitrous anhydride activity: 2 NO2- + 2 H+   [2 HONO]   N2O3 + H2O.	Water	143-146	carbonic anhydrase 4	Homo sapiens	26-30
29962845-6	2018	The goal of the present study was to evaluate the relationship between Phi, time, intracellular water content, and weight for head-and-neck cancer patients undergoing radiotherapy.	Water	96-101	glucose-6-phosphate isomerase	Homo sapiens	71-74
29962845-7	2018	The results demonstrate that Phi decreases with time and increases with intracellular water content and weight.	Water	86-91	glucose-6-phosphate isomerase	Homo sapiens	29-32
29574648-6	2018	Water with relatively high pH (e.g., ~ 8-9) favors the dissociated forms of TCH- and TC2- which are most susceptible to photochemical loss processes compared to neutral TC.	Water	0-5	transcobalamin 2	Homo sapiens	85-88
30956748-4	2018	The DSS aims to aid water treatment operation via source water impact analysis.	Water	20-25	activation induced cytidine deaminase	Homo sapiens	16-19
30956748-4	2018	The DSS aims to aid water treatment operation via source water impact analysis.	Water	57-62	activation induced cytidine deaminase	Homo sapiens	16-19
29624370-5	2018	Electrostatic and Lennard-Jones parameters for the model compounds are developed in the context of the polarizable SWM4-NDP water model, with emphasis on assuring that the hydration free energies are consistent with previously reported parameters for atomic ions.	Water	124-129	norrin cystine knot growth factor NDP	Homo sapiens	120-123
29735675-1	2018	Polypentagonal water networks were recently observed in a protein capable of binding to ice crystals, or ice-binding protein (IBP).	Water	15-20	trafficking protein particle complex subunit 9	Homo sapiens	105-124
29735675-1	2018	Polypentagonal water networks were recently observed in a protein capable of binding to ice crystals, or ice-binding protein (IBP).	Water	15-20	trafficking protein particle complex subunit 9	Homo sapiens	126-129
29735675-6	2018	These results suggest that a fine-tuning of the surface of Zoarcidae-derived IBP assisted by a side-chain group regulates the holding property of its polypentagonal water network, the function of which is to freeze the host protein to specific ice planes.	Water	165-170	trafficking protein particle complex subunit 9	Homo sapiens	77-80
29694779-4	2018	With the ad hoc inclusion of the isotropic polarizability, the polarizable SPC-3f(0.6) water model recovers the many-body effect of the second solvation shell.	Water	87-92	signal peptidase complex subunit 3	Homo sapiens	75-80
29769447-2	2018	We hypothesized that water entry was mediated by the water channel aquaporin-1 (AQP1) and aimed to determine its role in the platelet procoagulant response and thrombosis.	Water	21-26	aquaporin 1	Mus musculus	80-84
29769447-2	2018	We hypothesized that water entry was mediated by the water channel aquaporin-1 (AQP1) and aimed to determine its role in the platelet procoagulant response and thrombosis.	Water	53-58	aquaporin 1	Mus musculus	80-84
29729279-3	2018	Renal CAII and CAIV are involved in the reabsorption of nitrite, the autoxidation product of the signalling molecule nitric oxide (NO): 4 NO + O2 + 2 H2O   4 ONO- + 4 H+.	Water	150-153	carbonic anhydrase 4	Homo sapiens	15-19
29486360-7	2018	The results indicate that the presence of NOM in water samples may lead to false positive results for AhR activity and false positive results for AR and Nrf2 activity, when assessing inhibition of induced bioactivities from anthropogenic substances.	Water	49-54	aryl hydrocarbon receptor	Homo sapiens	102-105
29961215-3	2019	To address the mechanisms underlying AVP neuron loss, we subjected FNDI mice to intermittent water deprivation, which accelerated the phenotype and induced AVP neuron loss within a relative short period.	Water	93-98	arginine vasopressin	Mus musculus	156-159
29917204-10	2018	Intraventricular injection of Sesn2 siRNA lentivirus aggravated nerve function damage in MCAO model, increased cerebral infarction area and water content.	Water	140-145	sestrin 2	Rattus norvegicus	30-35
29961215-6	2019	Furthermore, the cytoplasm was entirely occupied with large vacuoles in AVP neurons of FNDI mice subjected to water deprivation for 12 weeks, at which stage 30-40% of AVP neurons were lost.	Water	110-115	arginine vasopressin	Mus musculus	72-75
29961215-6	2019	Furthermore, the cytoplasm was entirely occupied with large vacuoles in AVP neurons of FNDI mice subjected to water deprivation for 12 weeks, at which stage 30-40% of AVP neurons were lost.	Water	110-115	arginine vasopressin	Mus musculus	167-170
29408005-3	2018	When using matched water-DMSO blanks, thermal events at low temperatures are linked to the negation of mucin-DMSO interactions, while events at higher temperatures are linked to the break-up of hydrogen bonds connecting the sugars of the individual macromolecules.	Water	19-24	LOC100508689	Homo sapiens	103-108
29686047-8	2018	Cerebellar lobule I-IV, Broca area 44, and PMv showed greater voxel pattern differences for unconstrained than constrained grasping, which suggests their sensitivity to monitor the online coincidence of planned and actual digit positions and correct for a mismatch by force modulation.SIGNIFICANCE STATEMENT To pick up a water glass without slipping, tipping, or spilling requires anticipatory planning of fingertip load forces before the lift commences.	Water	321-326	Mitral valve prolapse, familial	Homo sapiens	43-46
30472169-7	2019	The detected complexes in the cCa fraction are mainly Ca(eta2-HPO4)(H2O)4 and Ca(eta1-HCO3)(H2O)5+, in which HPO42- and HCO3- serve as bidentate and unidentate ligands, respectively.	Water	68-71	DNA polymerase iota	Homo sapiens	57-61
29435998-6	2018	Exposure of immature granulosa cells to the polar fraction exerting 9 ng of 17beta-estradiol equivalents per liter of water of estrogenic activity increased mRNA expression of the key enzymes of progesterone biosynthetic pathway Star and Hsd3b1, but did not alter the level of Cyp19a1 and Lhr.	Water	118-123	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	277-284
29472120-6	2018	RESULTS: In CD6 KO mice with EAU, we found significantly decreased retinal inflammation and reduced autoreactive T-cell responses, and confirmed the impaired uveitogenic capacity of T cells from these mice in an adoptive transfer experiment.	Water	29-32	CD6 antigen	Mus musculus	12-15
31148068-1	2019	During exposure of cells to acute high dose-rate ionizing radiation (IR), oxidants from the radiolysis of water can overwhelm antioxidant systems.	Water	106-111	insulin receptor	Homo sapiens	69-71
29760327-3	2018	Therefore, with the incorporation of PSO4 into DPPC membranes, the amount of water required to reach the fully hydrated state was enhanced as indicated by the constant values of the main phase transition temperature (Tm) and the bilayer repeat distance (d).	Water	77-82	pre-mRNA processing factor 19	Homo sapiens	37-41
29760327-4	2018	For example, with the addition of 20 mol% of PSO4, the saturation point was shifted to ~70 wt% water compared to ~40 wt% for pure DPPC and 47 wt% for DPPC-cholesterol.	Water	95-100	pre-mRNA processing factor 19	Homo sapiens	45-49
29501193-6	2018	The SERS analysis of thiram dissolved in Aveiro Estuary water and in fruit juices have provided enhancement factors of 1.67 x 107 and 3.86 x 105, respectively, using the Ag/LCP composites.	Water	56-61	kelch domain containing 2	Homo sapiens	173-176
29501193-9	2018	SERS active Ag/LCP/PA filter membranes were also prepared using Ag/LCP composites supported by a polyamide (PA) filter, which can be an easy alternative to prepare simple, highly efficient and low-cost SERS active filter membranes for water analysis.	Water	235-240	kelch domain containing 2	Homo sapiens	12-21
29501193-9	2018	SERS active Ag/LCP/PA filter membranes were also prepared using Ag/LCP composites supported by a polyamide (PA) filter, which can be an easy alternative to prepare simple, highly efficient and low-cost SERS active filter membranes for water analysis.	Water	235-240	kelch domain containing 2	Homo sapiens	15-18
30219292-5	2019	Using this method, we detect increased BBB water permeability in a rat model of AD that is associated with reduced expression of the tight junction protein occludin.	Water	43-48	occludin	Rattus norvegicus	156-164
29721641-1	2018	In this work, we prepared CdTe quantum dots, and series of Cd1-xMnxTe-alloyed quantum dots with narrow size distribution by an ion-exchange reaction in water solution.	Water	152-157	CD1c molecule	Homo sapiens	59-62
29667677-6	2018	Regarding (ii), the influence of the interaction with ice on the Vertical Ionisation Potentials (VIPs) of the series of PAHs was determined using the constrained SCC-DFTB scheme benchmarked against correlated wavefunction results for PAH-(H2O)n (n = 1-6, 13) clusters.	Water	239-242	phenylalanine hydroxylase	Homo sapiens	120-123
29393658-4	2018	We propose that rapid water exchange through AQP1 coupled with large capacity for volume change may allow erythrocytes to play an important role in water regulation.	Water	22-27	aquaporin 1	Mus musculus	45-49
29393658-4	2018	We propose that rapid water exchange through AQP1 coupled with large capacity for volume change may allow erythrocytes to play an important role in water regulation.	Water	148-153	aquaporin 1	Mus musculus	45-49
29393658-7	2018	Constructing a microfluidic device resembling capillary flow with an extracellular fluorescent reporter demonstrated that water exchanges between erythrocytes and their hypotonic or hypertonic surroundings in vitro reached steady state in ~60 ms. AQP1 KO erythrocytes, however, did not show significant change.	Water	122-127	aquaporin 1	Mus musculus	247-251
29315935-4	2018	Here, we report molecular dynamics (MD) simulations of a solvated beta-galactosidase monomer, which illustrate how a water molecule located at the pi face of an indole side chain of tryptophan can adapt to the position of proximate residues and "select" its binding mode.	Water	117-122	galactosidase beta 1	Homo sapiens	66-84
29393658-14	2018	We conclude that fast water transport by aquaporin-1 coupled with large volume-change capacity allows erythrocytes to enhance water exchange with local tissues.	Water	22-27	aquaporin 1	Mus musculus	41-52
30507194-5	2018	The growth of water clusters changes the peak heights of the radial distribution functions in PF6 and NTf2 systems.	Water	14-19	sperm associated antigen 17	Homo sapiens	94-97
29393658-14	2018	We conclude that fast water transport by aquaporin-1 coupled with large volume-change capacity allows erythrocytes to enhance water exchange with local tissues.	Water	126-131	aquaporin 1	Mus musculus	41-52
30573626-0	2018	Root branching toward water involves posttranslational modification of transcription factor ARF7.	Water	22-27	ADP ribosylation factor like GTPase 14	Homo sapiens	92-96
29712953-4	2018	Additionally, exposure to original surface water sample collected from backwater area altered the expressions of sod-2, sod-5, clk-1, and mev-1.	Water	43-48	5-demethoxyubiquinone hydroxylase, mitochondrial	Caenorhabditis elegans	127-132
29632404-7	2018	The results showed that the organic molecules introduced by the herbal medicines are significant precursors to the formation of THMs in spa pool water.	Water	145-150	surfactant protein A1	Homo sapiens	136-139
29632404-8	2018	Since at least 50% of THMs were produced within the first six hours of the reaction time, the presence of herbal medicines in spa water could present a parallel route for THM exposure.	Water	130-135	surfactant protein A1	Homo sapiens	126-129
30560905-0	2018	Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells.	Water	134-139	cysteinyl-tRNA synthetase 1	Homo sapiens	71-75
29964986-8	2018	BDE-2 (65.80%) composed the main part of PBEDs in the surface water, and it mainly originated from atmospheric long-distance transmission and degradation of high brominated diphenyl ethers; BDE-209 (63.82%) constituted the main part of PBDEs in the surface sediment, and it mainly originated from the commercial Deca-BDEs.	Water	62-67	parathyroid hormone like hormone	Homo sapiens	0-5
28960009-0	2018	Effect of a single water molecule on the HO2 + ClO reaction.	Water	19-24	heme oxygenase 2	Homo sapiens	41-44
28960009-1	2018	The catalytic effect of a single water molecule on the HO2 + ClO reaction has been investigated at the CCSD(T)/aug-cc-pVTZ//B3LYP-D3/aug-cc-pVDZ level of theory.	Water	33-38	heme oxygenase 2	Homo sapiens	55-58
28960009-2	2018	Four H-abstraction paths and two kinds of products, among which the paths for HOCl + O2 formation are dominant, have been found for the HO2 + ClO reaction without water.	Water	163-168	heme oxygenase 2	Homo sapiens	136-139
28960009-6	2018	The most favorable paths, reactions between H2OHO2 and ClO, and between ClOH2O and HO2, are 7-10 and 6-9 orders of magnitude slower than the reaction in the absence of water, respectively.	Water	168-173	heme oxygenase 2	Homo sapiens	47-50
29471473-5	2018	The water-soluble GPR119 agonist, AR440006 (that cannot traverse epithelial tight junctions), elicited responses, when added apically or basolaterally in mouse and human colonic mucosae.	Water	4-9	G-protein coupled receptor 119	Mus musculus	18-24
30558326-6	2018	Thermal analysis (TGA-DSC) results showed that water desorption from microfibres at T = 150  C was close to 17 wt.%, a value in agreement with the adsorption capacity of pure SAPO-34.	Water	47-52	desmocollin 3	Homo sapiens	22-25
29414568-7	2018	Finally, the functionalized Ag NPs were successfully applied to detect Cr3+ and Hg2+ ions in water samples with satisfactory recoveries.	Water	93-98	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	71-74
30253178-4	2018	However, rate of water ingress of specimens was nearly same, but, the CCS/NGQD NC 8 wt% showed the more water absorption ability than the CCS.	Water	104-109	copper chaperone for superoxide dismutase	Homo sapiens	70-83
29304449-7	2018	In addition, PB/PAN exhibited excellent wettability with water.	Water	57-62	adenosine deaminase 2	Homo sapiens	16-19
29564896-1	2018	Two water-soluble [Au(9 N-adeninate)(PR3)] complexes (PR3 = PMe3 (1); PTA (3)) were synthesized by the coordination of the respective cationic [Au(PR3)]+ fragment to the 9 N position of the adeninate anion.	Water	4-9	proteinase 3	Homo sapiens	54-57
29513989-3	2018	Here, we demonstrate how the novel spectral decomposition techniques can extract important information from the computed IR spectra of aqueous solutions of BF4- and PF6-, interesting weakly coordinating anions that have been known for a long time to alter the IR spectrum of water in an unusual manner.	Water	275-280	sperm associated antigen 17	Homo sapiens	165-168
29513989-5	2018	We find, in accordance with previous experiments, a considerable blue shift of the nuOH stretching band of liquid water by 264 cm-1 for BF4- and 306 cm-1 for PF6-, with the affected numbers being 3.7 and 4.2, respectively.	Water	114-119	sperm associated antigen 17	Homo sapiens	158-161
29564896-1	2018	Two water-soluble [Au(9 N-adeninate)(PR3)] complexes (PR3 = PMe3 (1); PTA (3)) were synthesized by the coordination of the respective cationic [Au(PR3)]+ fragment to the 9 N position of the adeninate anion.	Water	4-9	proteinase 3	Homo sapiens	54-57
30253178-4	2018	However, rate of water ingress of specimens was nearly same, but, the CCS/NGQD NC 8 wt% showed the more water absorption ability than the CCS.	Water	104-109	copper chaperone for superoxide dismutase	Homo sapiens	70-73
29746796-0	2018	Detection of Bacteria in Water with beta-Galactosidase-Coated Magnetic Nanoparticles.	Water	25-30	galactosidase beta 1	Homo sapiens	36-54
28748627-10	2018	CONCLUSIONS: We propose that CAIX converts protons that either backflux or are extruded from the cells rapidly to CO2 and H2 O, contributing to tight junction protection and gastric epithelial pHi regulation.	Water	122-126	carbonic anhydrase 9	Mus musculus	29-33
29556787-6	2018	Thirdly, the cooperative action of Ang II acting on AT1R and AVP stimulating both V1aR and V2 receptors in the kidney is necessary for the appropriate regulation of renal blood flow and the efficient resorption of sodium and water.	Water	225-230	angiotensin II receptor type 1	Homo sapiens	52-56
29556787-6	2018	Thirdly, the cooperative action of Ang II acting on AT1R and AVP stimulating both V1aR and V2 receptors in the kidney is necessary for the appropriate regulation of renal blood flow and the efficient resorption of sodium and water.	Water	225-230	arginine vasopressin receptor 1A	Homo sapiens	82-86
30566098-3	2018	NO2-, NO3-, Fe3+ and Fe2+ extensively present in natural water can accelerate CN-1 photoconversion via generating  OH, which may induce indirect photooxidation of CN-1.	Water	57-62	5'-nucleotidase, cytosolic IA	Homo sapiens	78-82
29223455-8	2018	More importantly, the developed sensor manifests good stability at room temperature for 3months, which has been successfully used to determine Cr3+ and Pb2+ in the real water samples with a high sensitivity.	Water	169-174	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	143-146
29351432-0	2018	Diurnal pattern in skin Na+ and water content is associated with salt-sensitive hypertension in ETB receptor-deficient rats.	Water	32-37	endothelin receptor type B	Rattus norvegicus	96-99
30566098-3	2018	NO2-, NO3-, Fe3+ and Fe2+ extensively present in natural water can accelerate CN-1 photoconversion via generating  OH, which may induce indirect photooxidation of CN-1.	Water	57-62	5'-nucleotidase, cytosolic IA	Homo sapiens	163-167
29544301-2	2018	Our simulations clearly show that even at relatively high temperature of 270 K, the NQEs play a definite role in the pressure-induced proton order (ice VIII)-disorder (ice VII) transition occurring at ~30 GPa in our H2O ice and the subsequent transition to the symmetric phase ice X suggested to occur at ~80 GPa.	Water	216-219	cytochrome c oxidase subunit 8A	Homo sapiens	152-156
30398837-10	2018	And the removal efficiency for Cr3+ ions at 10 ppb can arrive at 99.2 wt % in the toluene-in-water emulsion.	Water	93-98	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	31-34
29492505-4	2018	We identify two characteristic temperatures (Tc1 and Tc2) at which the water desorption rate changes abruptly.	Water	71-76	transcobalamin 2	Homo sapiens	53-56
29678287-2	2018	AT1R plays a crucial role in the regulation of blood pressure and salt-water homeostasis, and in the development of pathological conditions, such as hypertension, heart failure, cardiovascular remodeling, renal fibrosis, inflammation, and metabolic disorders.	Water	71-76	angiotensin II receptor type 1	Homo sapiens	0-4
30442970-7	2018	The correlative biochemical analysis demonstrated that reduction of water content during dentin hybridization by the innovative dry-bonding approaches with DMSO is effective to inactivate host-derived MMP-2 and MMP-9 and thus reduce collagen degradation while simultaneously optimizing resin-dentin bonding.	Water	68-73	matrix metallopeptidase 2	Homo sapiens	201-206
29937596-7	2018	Under low water level, spatial structuring of environment decreased and pure environmental factors gained relevance for phytoplankton and rotifers.Our results suggest that although beta2 diversity between water sections is a major component of regional diversity, long-term spatial processes responding to connectivity across the wetland structure phytoplankton, rotifer and microcrustacean communities.	Water	10-15	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	181-186
29937596-7	2018	Under low water level, spatial structuring of environment decreased and pure environmental factors gained relevance for phytoplankton and rotifers.Our results suggest that although beta2 diversity between water sections is a major component of regional diversity, long-term spatial processes responding to connectivity across the wetland structure phytoplankton, rotifer and microcrustacean communities.	Water	205-210	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	181-186
29520400-0	2018	Role of the (H2O)n (n = 1-3) cluster in the HO2 + HO  3O2 + H2O reaction: mechanistic and kinetic studies.	Water	13-16	heme oxygenase 2	Homo sapiens	44-47
29520400-0	2018	Role of the (H2O)n (n = 1-3) cluster in the HO2 + HO  3O2 + H2O reaction: mechanistic and kinetic studies.	Water	60-63	heme oxygenase 2	Homo sapiens	44-47
32254215-3	2018	Here, water-soluble Cr3+-doped ZnGa2O4 PLNPs with the highest quantum yield (eta = 20%) ever reported, bright NIR emission, and excellent colloidal stability were successfully prepared by a one-step hydrothermal method.	Water	6-11	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	20-23
30441791-5	2018	An increase of residual chlorine in municipal drinking water was associated with a decrease in HFMD and AHC 2 and 3 months later.	Water	55-60	ATPase Na+/K+ transporting subunit alpha 3	Homo sapiens	104-115
29520400-2	2018	Our results show that upon incorporation of (H2O)n (n = 1-3) into the channel of H2O + 3O2 formation, two different reactions, i.e. HO + HO2(H2O)n (n = 1-3) and HO2 + HO(H2O)n (n = 1-3), have been observed, and these two reactions are competitive with each other.	Water	45-48	heme oxygenase 2	Homo sapiens	137-140
29520400-2	2018	Our results show that upon incorporation of (H2O)n (n = 1-3) into the channel of H2O + 3O2 formation, two different reactions, i.e. HO + HO2(H2O)n (n = 1-3) and HO2 + HO(H2O)n (n = 1-3), have been observed, and these two reactions are competitive with each other.	Water	45-48	heme oxygenase 2	Homo sapiens	161-164
30354154-0	2018	Cationic Hofmeister Series of Wettability Alteration in Mica-Water-Alkane Systems.	Water	61-66	MHC class I polypeptide-related sequence A	Homo sapiens	56-60
29590585-5	2018	The first or innermost hydration shell of the Mg2+ ion, however, is retained during the simulation because of the strong ion-water electrostatic attraction.	Water	125-130	mucin 7, secreted	Homo sapiens	46-49
29590585-6	2018	As a result, water-mediated hydrogen bonding remains an important form for Mg2+-RNA interaction.	Water	13-18	mucin 7, secreted	Homo sapiens	75-78
29422120-6	2018	These were due to the SWM4-NDP inherently overestimating the diffusion constant of water, a problem that was validated by calculation of the aqueous diffusion constants using the SWM6-NDP water model.	Water	83-88	norrin cystine knot growth factor NDP	Homo sapiens	27-30
29422120-6	2018	These were due to the SWM4-NDP inherently overestimating the diffusion constant of water, a problem that was validated by calculation of the aqueous diffusion constants using the SWM6-NDP water model.	Water	83-88	norrin cystine knot growth factor NDP	Homo sapiens	184-187
29422120-6	2018	These were due to the SWM4-NDP inherently overestimating the diffusion constant of water, a problem that was validated by calculation of the aqueous diffusion constants using the SWM6-NDP water model.	Water	188-193	norrin cystine knot growth factor NDP	Homo sapiens	27-30
29422120-6	2018	These were due to the SWM4-NDP inherently overestimating the diffusion constant of water, a problem that was validated by calculation of the aqueous diffusion constants using the SWM6-NDP water model.	Water	188-193	norrin cystine knot growth factor NDP	Homo sapiens	184-187
30141815-2	2018	CDT1 can offer an increase in the dispersibility of graphene in water and subsequent complexation of graphene and TiO2.	Water	64-69	chromatin licensing and DNA replication factor 1	Homo sapiens	0-4
29355738-1	2018	Carbonic anhydrase II (CA II) is a zinc metalloenzyme that catalyzes the reversible interconversion of water and CO2 to bicarbonate and a proton.	Water	103-108	carbonic anhydrase 2	Bos taurus	0-21
29355738-1	2018	Carbonic anhydrase II (CA II) is a zinc metalloenzyme that catalyzes the reversible interconversion of water and CO2 to bicarbonate and a proton.	Water	103-108	carbonic anhydrase 2	Bos taurus	23-28
29147935-0	2018	Nucleotide and octapeptide-repeat variations of the prion protein coding gene (PRNP) in Anatolian, Murrah, and crossbred water buffaloes.	Water	121-126	major prion protein	Bubalus bubalis	79-83
29147935-4	2018	Previous studies have demonstrated that the PRNP gene in water buffalo consists mostly of insertion alleles at both loci; nevertheless, whether or not water buffaloes are genetically resistant to BSE and the role of indel polymorphisms in their resistance status is not clear.	Water	57-62	major prion protein	Bubalus bubalis	44-48
29943435-4	2018	Male rats were exposed to the stress hormone corticosterone (Cort) in their drinking water, a vehicle control (2.5% ethanol), or water, for 7 days before being tested on a novel Object/Place task 6 days or 6 weeks later.	Water	85-90	cortistatin	Rattus norvegicus	61-65
29277736-2	2018	Sufficiently dilute suspensions are isotropic fluids, but as the concentration of CNC in water is increased, a critical concentration is reached where a spontaneously ordered phase is observed.	Water	89-94	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	82-85
29262302-13	2018	Water loss during milling was measured with TGA, showing lower water content for the lactose amorphized through milling compared to spray dried amorphous lactose.	Water	63-68	T-box transcription factor 1	Homo sapiens	44-47
30368623-4	2018	The MD analyses focus on the location of the ligands with respect to the experimental binding site and on the direct and water-mediated hydrogen bonds (H bonds) they form with CD58.	Water	121-126	CD58 molecule	Homo sapiens	176-180
29449549-3	2018	The fifth sentence of the second paragraph of the same section originally incorrectly read "In contrast, in the western section of the Nordic Seas, under the presence of warm Atlantic waters of the Norwegian Current, Nps was found to calcify deeper in the water column (100-200 m), whereas in the east under the influence of the EGC polar waters it calcified closer to the surface at a similar depth as Tq23."	Water	184-189	neuropeptide S	Homo sapiens	217-220
28858298-6	2018	The hydrogen bond mediated by crystallographic water between MS0 and His191 or Val350 of NAMPT did not exist in FK866.	Water	47-52	nicotinamide phosphoribosyltransferase	Homo sapiens	89-94
29179254-9	2018	Features essential for T4 lysozyme structure and function such as the distance between catalytic groups, salt bridge and presence of nucleophilic water are conserved in DLP12 endolysin and other endolysins analyzed.	Water	146-151	dynein axonemal heavy chain 12	Homo sapiens	169-174
29134712-8	2018	This is a typical case of degradation where co-solvents acetonitrile-water (50:50, v/v) and methanol-water (50:50, v/v) react with CAN under acid hydrolytic conditions leading to the formation of pseudo-DPs, DP3 and DP4, respectively.	Water	69-74	APC regulator of WNT signaling pathway	Homo sapiens	208-211
30500804-7	2018	In addition, composites with Ag2S loading of 1% possessed the highest hydrogen production ability of photolysis water, indicating that the introduction of Ag2S had significantly enhanced the catalytic performance.	Water	112-117	angiotensin II receptor type 1	Homo sapiens	29-33
29134712-8	2018	This is a typical case of degradation where co-solvents acetonitrile-water (50:50, v/v) and methanol-water (50:50, v/v) react with CAN under acid hydrolytic conditions leading to the formation of pseudo-DPs, DP3 and DP4, respectively.	Water	101-106	APC regulator of WNT signaling pathway	Homo sapiens	208-211
29445244-1	2018	Aquaporin TIP2;1 is a protein channel permeable to both water and ammonia.	Water	56-61	zinc finger and BTB domain containing 7A	Homo sapiens	10-16
29369758-7	2018	Model outputs yielded ranges for water and SSB prices that increased water demand without loss of profit from combined water and SSB sales.	Water	69-74	small RNA binding exonuclease protection factor La	Homo sapiens	43-46
29369758-8	2018	RESULTS: A 20% SSB price increase allowed lowering water prices by up to 20% while maintaining profit and increased water demand by 9% and 14%, for stores selling SSBs in 12-oz cans and 16- to 20-oz bottles, respectively.	Water	51-56	small RNA binding exonuclease protection factor La	Homo sapiens	15-18
29369758-8	2018	RESULTS: A 20% SSB price increase allowed lowering water prices by up to 20% while maintaining profit and increased water demand by 9% and 14%, for stores selling SSBs in 12-oz cans and 16- to 20-oz bottles, respectively.	Water	116-121	small RNA binding exonuclease protection factor La	Homo sapiens	15-18
29369758-10	2018	Sensitivity analysis showed that stores with a higher volume of SSB sales could reduce water prices the most without loss of profit.	Water	87-92	small RNA binding exonuclease protection factor La	Homo sapiens	64-67
29369758-11	2018	CONCLUSION: Various combinations of SSB and water prices could encourage water consumption while maintaining or increasing store owners" profits.	Water	73-78	small RNA binding exonuclease protection factor La	Homo sapiens	36-39
30500804-7	2018	In addition, composites with Ag2S loading of 1% possessed the highest hydrogen production ability of photolysis water, indicating that the introduction of Ag2S had significantly enhanced the catalytic performance.	Water	112-117	angiotensin II receptor type 1	Homo sapiens	155-159
30374933-3	2018	Although there is a relatively high removal percent of bacterial contamination from the water sources, however, several bacterial pathogens were identified in the produced water prepared for drinking including Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, and Shigella spp.	Water	172-177	histocompatibility minor 13	Homo sapiens	288-291
29360731-7	2018	After 48 h of inoculation, PR-8 expression in thyme-treated and inoculated apples was 4- and 6-fold higher than in inoculated and water-treated apples.	Water	130-135	pathogenesis-related protein 8	Malus domestica	27-31
29197144-3	2018	Here we report that water-soluble cyclic diselenides mimic the multifunctional activity of the PDI family by facilitating oxidative folding, disulfide formation/reduction, and repair of the scrambled disulfide bonds in misfolded proteins.	Water	20-25	prolyl 4-hydroxylase subunit beta	Homo sapiens	95-98
30080916-0	2018	Effectiveness of the monitoring program for ensuring the quality of water treated for dialysis in the state of Sao Paulo.	Water	68-73	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	111-114
29118028-1	2018	Although the functionality of the lens water channels aquaporin 1 (AQP1; epithelium) and AQP0 (fiber cells) is well established, less is known about the role of AQP5 in the lens.	Water	39-44	aquaporin 1	Rattus norvegicus	54-65
29118028-1	2018	Although the functionality of the lens water channels aquaporin 1 (AQP1; epithelium) and AQP0 (fiber cells) is well established, less is known about the role of AQP5 in the lens.	Water	39-44	aquaporin 1	Rattus norvegicus	67-71
29118028-2	2018	Since in other tissues AQP5 functions as a regulated water channel with a water permeability (PH2O) some 20 times higher than AQP0, AQP5 could function to modulate PH2O in lens fiber cells.	Water	53-58	aquaporin 5	Sus scrofa	23-27
29118028-2	2018	Since in other tissues AQP5 functions as a regulated water channel with a water permeability (PH2O) some 20 times higher than AQP0, AQP5 could function to modulate PH2O in lens fiber cells.	Water	53-58	aquaporin 5	Sus scrofa	132-136
29338044-6	2018	Using knock-in mouse models previously generated in our laboratory, in the present work, we identified genes that exhibited altered abundance in the mutant lenses, including decreased transcripts for Clic5, an intracellular water channel in Cryaa-R49C heterozygous mutant lenses, and increased transcripts for Eno1b in Cryab-R120G heterozygous mutant lenses.	Water	224-229	chloride intracellular channel 5	Mus musculus	200-205
29118028-2	2018	Since in other tissues AQP5 functions as a regulated water channel with a water permeability (PH2O) some 20 times higher than AQP0, AQP5 could function to modulate PH2O in lens fiber cells.	Water	74-79	aquaporin 5	Sus scrofa	23-27
30096751-6	2018	The concentrations of HANs, HKs, and their compounds, including chloropicrin (CPK), were highly variable in different water systems in Quebec.	Water	118-123	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	78-81
29118028-2	2018	Since in other tissues AQP5 functions as a regulated water channel with a water permeability (PH2O) some 20 times higher than AQP0, AQP5 could function to modulate PH2O in lens fiber cells.	Water	74-79	aquaporin 5	Sus scrofa	132-136
29103486-1	2018	We designed an injectable hydrogel by dissolving MoS2/Bi2S3-PEG (MBP), doxorubicin (DOX) and agar into water for the concurrent tumor photothermal and chemotherapy.	Water	103-108	myelin basic protein	Homo sapiens	65-68
30096751-8	2018	Factors such as system size, water source, season, pH, total organic carbon content, free residual chlorine and disinfectant types cause significant variations in the concentrations of HANs, HKs and their constituent compounds, including CPK, in drinking water in Quebec.	Water	255-260	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	238-241
28873532-0	2018	Effect of sodium alginate with three molecular weight forms on the water holding capacity of chicken breast myosin gel.	Water	67-72	myosin, heavy chain 15	Gallus gallus	108-114
28960813-5	2018	This new type of NIR emission in Ag2 S with sizes greater than 5 nm is due to the proximity of a highly deficient CdS shell with strong red emission that was stable for more than 6 months in water.	Water	191-196	angiotensin II receptor type 1	Homo sapiens	33-38
29954556-4	2018	The optimized NiCoOx provided a synergistic effect for efficient water oxidation, with an overpotential of 250 mV and a low Tafel slope of 48 mV   dec-1.	Water	65-70	deleted in esophageal cancer 1	Homo sapiens	147-152
29278318-4	2018	The phosphine gas generated from the thermal decomposition of NaH2PO2 H2O induces the formation of P-g-C3N4 nanotubes from g-C3N4 nanosheets, leads to an enlarged BET surface area and a unique mesoporous structure, and creates an amino-rich surface.	Water	70-73	delta/notch like EGF repeat containing	Homo sapiens	163-166
28873532-4	2018	This aggregation induced the increased turbidity, transition temperature and the decreased surface hydrophobicity of myosin-SA solutions and the formation of an inhomogeneous network with large cavities for entrapping water.	Water	218-223	myosin, heavy chain 15	Gallus gallus	117-123
28873577-9	2018	Dissociation of the kafirin molecules in GAA, assuming a alpha-helical conformation may have enhanced water binding, enabling viscoelastic mass formation.	Water	102-107	alpha glucosidase	Homo sapiens	41-44
30176720-8	2018	Human respiration, palm sweat, urine, and water droplets were delicately detected by the SnS2/Zn2SnO4 humidity sensor, indicating its great potential in multifarious application fields.	Water	42-47	sodium voltage-gated channel alpha subunit 11	Homo sapiens	89-93
28985278-7	2018	RESULTS: SBP was lower by 5.1 +- 1.0 mm Hg after WATER than CONTROL over 21 hours (P &lt; 0.001), over awake hours by 5.7 +- 1.1 mm Hg (P &lt; 0.001), and sleep hours by 4.5 +- 0.4 mm Hg (P = 0.004).	Water	49-54	selenium binding protein 1	Homo sapiens	9-12
29299926-7	2018	The present study implied highly promising perspectives of water-compatible eco-friendly mt-MIBP for highly effective multiresidue analysis in complicated matrixes.	Water	59-64	nicotinamide riboside kinase 2	Homo sapiens	92-96
30596177-12	2019	Conclusion: Reduced NCC expression and increased AQP2 expression would be expected to result in saliuresis and water reabsorption in TIH patients.	Water	111-116	solute carrier family 12 member 3	Homo sapiens	20-23
29373601-16	2018	A time effect was observed for the cell membrane sodium-dependent glucose transporter SLC5A1, for the major carbohydrate facilitated transporter SLC2A2, and water transport function AQP3, where SLC5A1 and AQP3 had a negative quadratic effect over time.	Water	157-162	aquaporin 3	Bos taurus	182-186
29373601-16	2018	A time effect was observed for the cell membrane sodium-dependent glucose transporter SLC5A1, for the major carbohydrate facilitated transporter SLC2A2, and water transport function AQP3, where SLC5A1 and AQP3 had a negative quadratic effect over time.	Water	157-162	solute carrier family 5 member 1	Bos taurus	194-200
29320695-7	2018	The gating transition is accompanied by a large increase in the protein-water electrostatic interaction energy, which supports the contribution of desolvation of polar/charged residues to the temperature-sensitive TRPV1 gating.	Water	72-77	transient receptor potential cation channel subfamily V member 1	Homo sapiens	214-219
28854386-0	2018	First principles computational study on hydrolysis of hazardous chemicals phosphorus trichloride and oxychloride (PCl3 and POCl3) catalyzed by molecular water clusters.	Water	153-158	PHD finger protein 19	Homo sapiens	114-118
28854386-1	2018	Using first principles calculations we unveil fundamental mechanism of hydrolysis reactions of two hazardous chemicals PCl3 and POCl3 with explicit molecular water clusters nearby.	Water	158-163	PHD finger protein 19	Homo sapiens	119-123
30237422-6	2018	The total loss area of natural ecological systems (forests, shrubs and meadows) for a new ski resort is 117.27 hm2, which will lead to ecosystem function loss such as water and soil conservation and will potentially impact ecological systems.	Water	167-172	cholinergic receptor muscarinic 2	Homo sapiens	111-114
29354070-2	2017	Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel.	Water	51-56	aquaporin 1	Mus musculus	0-11
29354070-2	2017	Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel.	Water	51-56	aquaporin 1	Mus musculus	13-17
29354070-2	2017	Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel.	Water	74-79	aquaporin 1	Mus musculus	0-11
29354070-2	2017	Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel.	Water	74-79	aquaporin 1	Mus musculus	13-17
29354070-11	2017	CAII associates with and increases water flux through aquaporin-1.	Water	35-40	aquaporin 1	Mus musculus	54-65
29266947-2	2018	By using the interacting quantum atoms (IQA) approach together with electron distribution functions (EDF) and the natural adaptive orbitals (NAdOs) picture, we show that, in agreement with orbital-based analyses, the interaction in simple sigma and pi complexes formed by BeX2 (X = H, F, Cl) with water, ammonia, ethylene, and acetylene is dominated by electrostatic terms, albeit covalent contributions cannot be ignored.	Water	297-302	brain expressed X-linked 2	Homo sapiens	272-276
29354070-12	2017	Water flux through aquaporin-1 in the TDL of the loop of Henle is essential to the concentration of urine, as this is required to generate a concentrated medullary interstitium.	Water	0-5	aquaporin 1	Mus musculus	19-30
30237459-3	2018	Nevertheless, the surface water sample collected from backwater area induced the significant increase in expressions of genes (sod-2 and sod-3) encoding Mn-SODs in wild-type nematodes.	Water	26-31	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	137-142
29354070-15	2017	We propose therefore that reduced water flux through aquaporin-1 in the TDL in the absence of CAII prevents the generation of a maximally concentrated medullary interstitium.	Water	34-39	aquaporin 1	Mus musculus	53-64
29313861-0	2018	Investigation of the water-stimulated Mg2+ insertion mechanism in an electrodeposited MnO2 cathode using X-ray photoelectron spectroscopy.	Water	21-26	mucin 7, secreted	Homo sapiens	38-41
30237459-4	2018	Among the examined five original surface water samples, exposure to the original surface water sample collected from backwater area could further cause the toxicity in decreasing locomotion behavior and in inducing intestinal ROS production in sod-3 mutant nematodes.	Water	41-46	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	244-249
30237459-4	2018	Among the examined five original surface water samples, exposure to the original surface water sample collected from backwater area could further cause the toxicity in decreasing locomotion behavior and in inducing intestinal ROS production in sod-3 mutant nematodes.	Water	89-94	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	244-249
30237459-5	2018	Moreover, the solid phase of surface water sample collected from backwater area might mainly contribute to the observed toxicity in sod-3 mutant nematodes.	Water	37-42	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	132-137
29250616-4	2018	Thus, the activated indium MOF was applied for As removal from water for the first time and showed a high arsenate uptake capacity of 103.1 mg g-1 at neutral pH, which is higher than the commercial adsorbents (usually less than 100 mg g-1 at neutral pH).	Water	63-68	lysine acetyltransferase 8	Homo sapiens	27-30
29170024-0	2018	Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.	Water	13-18	delta/notch like EGF repeat containing	Homo sapiens	77-80
29891287-2	2018	The introduction of an amine at the C-6 position of chitosan has led to the synthesis of a water-soluble chitosan derivative, 6-deoxy-6-amino chitosan.	Water	91-96	complement C6	Homo sapiens	36-39
29863060-3	2018	Because 2% surfactant was contained in S-55, the UTI injection solution formed a water-in-oil type emulsion as a suppository base.	Water	81-86	alpha-1-microglobulin/bikunin precursor	Homo sapiens	49-52
29172489-0	2018	Ligand-Directed Reactivity in Dioxygen and Water Binding to cis-[Pd(NHC)2(eta2-O2)].	Water	43-48	DNA polymerase iota	Homo sapiens	74-78
29172489-4	2018	In addition to reaction with O2, cis-[Pd(IPr)2(eta2-O2)] reacts at low temperature with H2O in methanol/ether solution to form trans-[Pd(IPr)2(OH)(OOH)].	Water	88-91	DNA polymerase iota	Homo sapiens	47-54
29767557-8	2018	Conversely, mRNA expression levels in kidney of genes encoding solute and water transporters in the proximal tubule ( Abcg2 and Slc34a1) and collecting duct ( Aqp2, Scnn1a, and Scnn1b) remained comparable between control and iKsp- Pkd1-/- mice, although a water reabsorption defect was observed in iKsp- Pkd1-/- mice.	Water	74-79	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	118-123
30471658-6	2018	The maximum concentrations of metformin and guanylurea in surface water samples were as high as 59,000 and 4502ngL-1, respectively.	Water	66-71	Netrin-G1 ligand	Salmo salar	111-116
29127639-0	2018	Reactivation and reuse of TiO2-SnS2 composite catalyst for solar-driven water treatment.	Water	72-77	sodium voltage-gated channel alpha subunit 11	Homo sapiens	31-35
29879534-6	2018	The radon concentrations in tap water samples were found to be in the range of 0.98 Bq/L-27.28 Bq/L.	Water	32-37	ribosomal protein L27	Homo sapiens	87-91
29127639-3	2018	Such a catalytic system was applied in solar-driven treatment, solar/TiO2-SnS2/H2O2, for the purification of water contaminated with diclofenac (DCF).	Water	109-114	sodium voltage-gated channel alpha subunit 11	Homo sapiens	74-78
29127639-8	2018	Such alteration, repeated through consecutive reactivation and reuse, was reflected through gradual activity loss of TiO2-SnS2 composite in applied solar-driven water treatment.	Water	161-166	sodium voltage-gated channel alpha subunit 11	Homo sapiens	122-126
28906027-0	2018	SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling.	Water	71-76	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	5-10
28906027-5	2018	Here, using co-immunoprecipitation and Forster resonance energy transfer, we report that AQP4 physically co-assembles with the sulfonylurea receptor 1-transient receptor potential melastatin 4 (SUR1-TRPM4) monovalent cation channel to form a novel heteromultimeric water/ion channel complex.	Water	265-270	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	199-204
28906027-6	2018	In vitro cell-swelling studies using calcein fluorescence imaging of COS-7 cells expressing various combinations of AQP4, SUR1, and TRPM4 showed that the full tripartite complex, comprised of SUR1-TRPM4-AQP4, was required for fast, high-capacity transmembrane water transport that drives cell swelling, with these findings corroborated in cultured primary astrocytes.	Water	260-265	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	197-202
28906027-8	2018	Together, these findings demonstrate a novel molecular mechanism involving the SUR1-TRPM4-AQP4 complex to account for bulk water influx during astrocyte swelling.	Water	123-128	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	84-89
29101691-5	2018	First, the nitrogen (N) and phosphorus (P) emission loads to water environment were estimated to be 1.44 Tg N and 0.06 Tg P, respectively.	Water	61-66	transglutaminase 4	Homo sapiens	119-123
28834703-6	2018	Therefore, the as-prepared CTS-g-AMPS magnetic adsorbent is potential to be used for adsorption removal of antibiotics from water.	Water	124-129	adenylosuccinate lyase	Homo sapiens	33-37
29943426-2	2018	In humans, several P450 isoforms constitute the largest part of phase I metabolizing enzymes and catalyze oxidation reactions which convert lipophilic xenobiotics, including drugs, to more water soluble species.	Water	189-194	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	19-23
28939924-2	2018	The objective of this study was to characterize PAH levels in people living near oil drilling operations in relation to fish consumption, occupation, source of water and other socio-demographic characteristics.	Water	160-165	phenylalanine hydroxylase	Homo sapiens	48-51
29692019-9	2018	The highest water consumption and daily water consumption intensity were both obtained under 90000 plants hm-2 treatment, which increased by 6.8%-15.7% and 7.0%-20.0% compared with other plant density treatments.	Water	12-17	Putative anthocyanidin reductase	Zea mays	106-110
29692019-9	2018	The highest water consumption and daily water consumption intensity were both obtained under 90000 plants hm-2 treatment, which increased by 6.8%-15.7% and 7.0%-20.0% compared with other plant density treatments.	Water	40-45	Putative anthocyanidin reductase	Zea mays	106-110
29112376-5	2017	In our current experiment, we achieved thermal isolation from the environment and studied the fully reversible ice-liquid water transition for water confined between graphene and muscovite mica.	Water	122-127	MHC class I polypeptide-related sequence A	Homo sapiens	189-193
29112376-5	2017	In our current experiment, we achieved thermal isolation from the environment and studied the fully reversible ice-liquid water transition for water confined between graphene and muscovite mica.	Water	143-148	MHC class I polypeptide-related sequence A	Homo sapiens	189-193
29135237-6	2017	Moreover, the initial degradation of PVP and the subsequent transformation of PES could be highly responsible for the increased water permeability and the enlargement of membrane pores, respectively, both leading to serious fouling with humic acid filtration.	Water	128-133	pescadillo ribosomal biogenesis factor 1	Homo sapiens	78-81
28888859-1	2017	We developed an electrochemical microalgal bioassay for the determination of heavy metal toxicity in water on the basis of the alkaline phosphatase (ALP) enzyme inhibition of Chlamydomonas reinhardtii.	Water	101-106	uncharacterized protein	Chlamydomonas reinhardtii	127-147
28888859-1	2017	We developed an electrochemical microalgal bioassay for the determination of heavy metal toxicity in water on the basis of the alkaline phosphatase (ALP) enzyme inhibition of Chlamydomonas reinhardtii.	Water	101-106	uncharacterized protein	Chlamydomonas reinhardtii	149-152
28531916-2	2017	Geological fluorapatite (FAp) is the dominant mineral-weathering source of P. In this study, FAp was added into water and soil under elevated CO2 to investigate the pathway of P release.	Water	112-117	fibroblast activation protein alpha	Homo sapiens	93-96
29165378-4	2017	The main driving factors which influenced sediment phosphorus flux velocity in the sediment-water interface were sediment B-SO42-, B-MBN and A-MBP content.	Water	92-97	myelin basic protein	Homo sapiens	143-146
29165378-6	2017	Sediment B-SO42-, B-MBN and A-MBP content and the interaction between them were the main factors affecting sediment phosphorus release rates in the sediment-water interface.	Water	157-162	alpha-1-microglobulin/bikunin precursor	Homo sapiens	9-33
29023122-4	2017	They offer highly oxidizing potentials (&gt;1 V vs NHE in aqueous solution) that are sufficient to drive a water oxidation catalyst and excited-state potentials (~-1.2 V vs NHE) sufficient to inject into TiO2.	Water	107-112	solute carrier family 9 member C1	Homo sapiens	51-54
29023122-4	2017	They offer highly oxidizing potentials (&gt;1 V vs NHE in aqueous solution) that are sufficient to drive a water oxidation catalyst and excited-state potentials (~-1.2 V vs NHE) sufficient to inject into TiO2.	Water	107-112	solute carrier family 9 member C1	Homo sapiens	173-176
28894966-6	2017	Naturally occurring 1 and its analog 3 that adopt similar conformation in water bind preferentially L-fucose, and to a lesser degree D-galactose and N-acetyl-D-galactosamine, typically found within the mucin O-glycan core structures.	Water	74-79	LOC100508689	Homo sapiens	202-207
28401699-3	2017	Subsequent to contraction of the ventral pouch and concomitant expulsion of the mouthful of ingested water, these three structures together, we contend, aid in (1) channeling prey posteriorly toward the esophageal opening; (2) concentrating prey as excess water is squeezed from (what is presumed to be) the slurry-like mixture of nektonic and/or planktonic prey and water; and (3) guiding prey into the isthmus of the fauces while simultaneously (4) facilitating expulsion of water.	Water	101-106	activation induced cytidine deaminase	Homo sapiens	153-156
28401699-3	2017	Subsequent to contraction of the ventral pouch and concomitant expulsion of the mouthful of ingested water, these three structures together, we contend, aid in (1) channeling prey posteriorly toward the esophageal opening; (2) concentrating prey as excess water is squeezed from (what is presumed to be) the slurry-like mixture of nektonic and/or planktonic prey and water; and (3) guiding prey into the isthmus of the fauces while simultaneously (4) facilitating expulsion of water.	Water	256-261	activation induced cytidine deaminase	Homo sapiens	153-156
28401699-3	2017	Subsequent to contraction of the ventral pouch and concomitant expulsion of the mouthful of ingested water, these three structures together, we contend, aid in (1) channeling prey posteriorly toward the esophageal opening; (2) concentrating prey as excess water is squeezed from (what is presumed to be) the slurry-like mixture of nektonic and/or planktonic prey and water; and (3) guiding prey into the isthmus of the fauces while simultaneously (4) facilitating expulsion of water.	Water	256-261	activation induced cytidine deaminase	Homo sapiens	153-156
28401699-3	2017	Subsequent to contraction of the ventral pouch and concomitant expulsion of the mouthful of ingested water, these three structures together, we contend, aid in (1) channeling prey posteriorly toward the esophageal opening; (2) concentrating prey as excess water is squeezed from (what is presumed to be) the slurry-like mixture of nektonic and/or planktonic prey and water; and (3) guiding prey into the isthmus of the fauces while simultaneously (4) facilitating expulsion of water.	Water	256-261	activation induced cytidine deaminase	Homo sapiens	153-156
28976750-4	2017	Arctii Fructus water extract (AFW) or ethanol extract (AFE) and ARC reduced the production of histamine and pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-6, IL-8, and TNF-alpha in mast cells.	Water	15-20	chemokine (C-X-C motif) ligand 15	Mus musculus	173-177
28981265-0	2017	Solid-in-Oil-in-Water Emulsions for Delivery of Lactase To Control in Vitro Hydrolysis of Lactose in Milk.	Water	16-21	lactase	Homo sapiens	48-55
28981265-2	2017	In this work, spray-dried lactase powder was encapsulated in solid-in-oil-in-water (S/O/W) emulsions to fabricate delivery systems.	Water	77-82	lactase	Homo sapiens	26-33
29311752-3	2017	Because of poor solubility, water-soluble prodrugs of CA-4 and CA-1 have been developed, which are currently in human clinical trials.	Water	28-33	carbonic anhydrase 4	Homo sapiens	54-58
28074609-6	2017	Fat-water separation in a single acquisition was performed using both multi-echo fast spin echo and GRASE as compared to conventional multiacquisition fast spin echo with echo shifts.	Water	4-9	glutathione-disulfide reductase	Homo sapiens	100-105
29088069-0	2017	Refined Deep-Sea Water Suppresses Inflammatory Responses via the MAPK/AP-1 and NF-kappaB Signaling Pathway in LPS-Treated RAW 264.7 Macrophage Cells.	Water	17-22	jun proto-oncogene	Mus musculus	70-74
29629084-0	2018	Overcoming double-step CO2 adsorption and minimizing water co-adsorption in bulky diamine-appended variants of Mg2(dobpdc).	Water	53-58	mucin 7, secreted	Homo sapiens	115-121
28495631-6	2017	More strikingly, Ag2S-Chitosan nanocomposites and Ag2S-chitosan nanohybrids are also demonstrated to nearly completely remove Clindamycin from drinking water.	Water	152-157	angiotensin II receptor type 1	Homo sapiens	17-21
28495631-6	2017	More strikingly, Ag2S-Chitosan nanocomposites and Ag2S-chitosan nanohybrids are also demonstrated to nearly completely remove Clindamycin from drinking water.	Water	152-157	angiotensin II receptor type 1	Homo sapiens	50-54
30656065-3	2018	Water insoluble combretastatin (CA4) was conjugated to a small-sized water soluble G3-succinamic acid PAMAM dendrimer.	Water	0-5	carbonic anhydrase 4	Rattus norvegicus	32-35
30656065-3	2018	Water insoluble combretastatin (CA4) was conjugated to a small-sized water soluble G3-succinamic acid PAMAM dendrimer.	Water	69-74	carbonic anhydrase 4	Rattus norvegicus	32-35
28947304-7	2018	In multivariable Cox-regression analyses, EAU intermediate- and high-risk categories were associated with a higher risk of disease recurrence (P&lt;0.001) and progression (P&lt;0.001) compared to low-risk patients.	Water	42-45	cytochrome c oxidase subunit 8A	Homo sapiens	17-20
32264571-5	2017	Amphiphilic self-assembled PeptiSomes in water were capable of disassembling and releasing the encapsulated self-quenched fluorescence dye (calcein) via enzymatic activation by MT1-MMP.	Water	41-46	matrix metallopeptidase 14	Homo sapiens	177-184
29148721-2	2017	Herein, a guest-encapsulation metal-organic framework (MOF), Ru@MIL-NH2, is prepared with 2-aminoterephthalic acid, AlCl3, and Ru(bpy)32+ by a simple one-pot method for ratiometric fluorescence sensing of water in organic solvents.	Water	205-210	lysine acetyltransferase 8	Homo sapiens	30-59
29184932-1	2017	The conveniently obtained water-soluble small-molecule L1-5 were selective for RNA with remarkable "off-on" two-photon fluorescence responses in vitro and in vivo, showing that L1-5 can surprisingly stain mitochondria or nucleoli individually with orange fluorescence under different focal lengths.	Water	26-31	immunoglobulin kappa variable 1D-16	Homo sapiens	55-59
29184932-1	2017	The conveniently obtained water-soluble small-molecule L1-5 were selective for RNA with remarkable "off-on" two-photon fluorescence responses in vitro and in vivo, showing that L1-5 can surprisingly stain mitochondria or nucleoli individually with orange fluorescence under different focal lengths.	Water	26-31	immunoglobulin kappa variable 1D-16	Homo sapiens	177-181
29210997-6	2017	Chronic tempol supplementation in the drinking water increased diaphragm functional capacity and citrate synthase and lactate dehydrogenase enzymatic activities, restoring all values to wild-type levels.	Water	47-52	citrate synthase	Mus musculus	97-113
28744670-7	2017	Our data shed new light on the crucial role of HuR as a stabilizing factor for the MR transcript and provide evidence for a short autoregulatory loop in which expression of a nuclear receptor transcriptionally regulating water and sodium balance is controlled by osmotic tone.	Water	221-226	nuclear receptor subfamily 3 group C member 2	Homo sapiens	83-85
28940861-7	2017	Thus, Ang-(1-7)-induced increases in sodium and water excretion are dependent upon functional Mas and AT1 receptors.	Water	48-53	angiotensin II receptor, type 1a	Rattus norvegicus	102-105
29107214-6	2017	We found that ICH promoted Tim-3 expression and M1 polarization in the perihematomal region of WT mice, leading to increased brain water content and neurological impairment.	Water	131-136	hepatitis A virus cellular receptor 2	Mus musculus	27-32
29107214-7	2017	However, deletion of Tim-3 expression attenuated M1 polarization, decreased rain water content and improved neurological function of ICH mice.	Water	81-86	hepatitis A virus cellular receptor 2	Mus musculus	21-26
29196683-0	2017	Preferential selection of Arginine at the lipid-water-interface of TRPV1 during vertebrate evolution correlates with its snorkeling behaviour and cholesterol interaction.	Water	48-53	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-72
29196683-4	2017	Here we analysed the molecular evolution of TRPV1 at the lipid-water-interface region (LWI), typically defined as a layer of 6 A thickness on each side of the membrane with less availability of free water.	Water	63-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	44-49
29196683-4	2017	Here we analysed the molecular evolution of TRPV1 at the lipid-water-interface region (LWI), typically defined as a layer of 6 A thickness on each side of the membrane with less availability of free water.	Water	199-204	transient receptor potential cation channel subfamily V member 1	Homo sapiens	44-49
28963036-8	2017	Overall, this data indicated that the co-delivery of PLP and dexamethasone with a water-in-oil emulsion is effective in treating a murine autoimmune model.	Water	82-87	proteolipid protein (myelin) 1	Mus musculus	53-56
28865376-2	2017	The microbial growth potential (MGP) of the finished water was measured with the assimilable organic carbon (AOC) method using pure cultures and the biomass production potential (BPP) test.	Water	53-58	matrix Gla protein	Homo sapiens	32-35
29209206-4	2017	In this paper, we synthesized a targeting drug delivery system (TDDS) to improve the water-solubility of photosensitizer and enhance the ability of targeted TFR positive tumor cells.	Water	85-90	transferrin receptor	Mus musculus	157-160
29250399-8	2017	In both salt and co-crystal, the water mol-ecule links the chloranilic acid and 2-carb-oxy-pyridine mol-ecules through O-H O and N-H O hydrogen bonds.	Water	33-38	syntaxin 8	Homo sapiens	82-86
29250399-11	2017	The water mol-ecule links the chloranilic acid and 2-carb-oxy-quinoline mol-ecules through O-H O hydrogen bonds.	Water	4-9	syntaxin 8	Homo sapiens	53-57
28689602-3	2017	MATERIALS AND METHODS: Maceration of the herb in water afforded malva nut polysaccharide which was standardized.	Water	49-54	NUT midline carcinoma family member 1	Homo sapiens	70-73
28074609-1	2017	PURPOSE: To investigate the feasibility of chemical shift encoded, single-slab 3D GRASE for rapid fat-water separation within a single acquisition.	Water	102-107	glutathione-disulfide reductase	Homo sapiens	82-87
28985466-0	2017	Charge Induced Dynamics of Water in a Graphene-Mica Slit Pore.	Water	27-32	MHC class I polypeptide-related sequence A	Homo sapiens	47-51
28985466-1	2017	We use atomic force microscopy to in situ investigate the dynamic behavior of confined water at the interface between graphene and mica.	Water	87-92	MHC class I polypeptide-related sequence A	Homo sapiens	131-135
28985466-3	2017	At high humidity, a third water layer will intercalate between graphene and mica.	Water	26-31	MHC class I polypeptide-related sequence A	Homo sapiens	76-80
29750207-3	2017	The conventional GTPase mechanism such as in H-Ras requires a conserved glutamine (Q64) in the switch-II region of RheB to align the catalytic water molecule for efficient GTP hydrolysis.	Water	143-148	Ras homolog, mTORC1 binding	Homo sapiens	115-119
29629084-4	2018	This two-step behavior likely results from steric interactions between ammonium carbamate chains induced by the asymmetrical hexagonal pores of Mg2(dobpdc) and leads to decreased CO2 working capacities and increased water co-adsorption under humid conditions.	Water	216-221	mucin 7, secreted	Homo sapiens	144-155
29061187-12	2017	Injection of miR-129-5p mimic preserved motor function and prevented BSCB leakage based on increased Basso Mouse Scale scores and decreased EB extravasation and water content, whereas injection rHMGB1 and Poly(I:C) aggravated these injuries.	Water	161-166	microRNA 297b	Mus musculus	13-16
31966366-11	2017	Overexpression of miR-21 or knockdown of PDCD4 promoted ATII cell proliferation and inhibited ATII cell apoptosis after treatment with H2O2.	Water	135-139	programmed cell death 4	Homo sapiens	41-46
30010841-5	2018	qnrA, intI1 and sul1 genes in surface water were significantly higher than erm(B) and tet(W); however, no difference was present in sediment samples.	Water	38-43	dihydropteroate synthase	Escherichia coli	16-20
28614117-9	2017	SUMMARY: AMPK in the kidney plays a unique role at the crossroads of energy metabolism, ion and water transport, inflammation, and stress.	Water	96-101	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	9-13
30070818-0	2018	Extra Water- and Acid-Stable MOF-801 with High Proton Conductivity and Its Composite Membrane for Proton-Exchange Membrane.	Water	6-11	lysine acetyltransferase 8	Homo sapiens	29-32
30070818-3	2018	In this study, we demonstrate that MOF-801 shows remarkable proton conductance with sigma = 1.88 x 10-3 S cm-1 at 298 K and 98% relative humidity (RH), specifically, together with extra stability to hydrochloric acid or diluting sodium hydroxide aqueous solutions and boiling water.	Water	276-281	lysine acetyltransferase 8	Homo sapiens	35-38
28572445-5	2017	Use of a water-soluble p38 inhibitor curtailed activation in vivo of MAPKs and Akt in LV CMs as well as the appearance of cytokines and histones in plasma from CLP mice.	Water	9-14	mitogen-activated protein kinase 14	Mus musculus	23-26
29944367-1	2018	Monte Carlo sampling calculations were performed to determine the anharmonic sum of states, Nanh( E), for I-(H2O), (H2O)2, and I-(H2O)2 versus internal energy up to their dissociation energies.	Water	109-112	neuraminidase 1	Homo sapiens	92-96
28498931-2	2017	Although short- or long-term intake of spa water is effective in increasing gastric mucosal blood flow, and spa water therapy is useful for treating chronic gastritis and gastric ulcer, the underlying mechanisms for and precise effects of radon protection against mucosal injury are unclear.	Water	43-48	surfactant associated protein A1	Mus musculus	39-42
30104609-11	2018	Results of MD simulations clearly revealed the influence of TM4-TM5 interface in modulating the water transport of ZmPIP1;2.	Water	96-101	aquaporin PIP1-2	Zea mays	115-123
28498931-2	2017	Although short- or long-term intake of spa water is effective in increasing gastric mucosal blood flow, and spa water therapy is useful for treating chronic gastritis and gastric ulcer, the underlying mechanisms for and precise effects of radon protection against mucosal injury are unclear.	Water	112-117	surfactant associated protein A1	Mus musculus	108-111
30104609-12	2018	MD simulations indicate the importance of I93 residue from the TM2 segment of ZmPIP2;5 for the increased water transport in ZmPIP1;2.	Water	105-110	aquaporin PIP1-2	Zea mays	124-132
28546106-3	2017	We improved the solubility of EPL in water by adding beta-CD derivatives.	Water	37-42	beta-carotene oxygenase 1	Mus musculus	53-60
29730553-3	2018	The dual behavior of SB Cr3+ conjugates i.e. self-aggregation in high water fraction (fw &gt; 50%) and dissolution in low water fraction (fw &lt; 50%) proves this conjugation excellent tool for monitoring Cr3+ ions.	Water	70-75	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	24-27
28703592-2	2017	The hydrophilic aromatic groups of all five beta2 agonists show maximum distribution in the lipid/water interface, but distinct location and dynamic behavior were observed for the lipophilic aromatic rings.	Water	98-103	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	44-49
29730553-3	2018	The dual behavior of SB Cr3+ conjugates i.e. self-aggregation in high water fraction (fw &gt; 50%) and dissolution in low water fraction (fw &lt; 50%) proves this conjugation excellent tool for monitoring Cr3+ ions.	Water	122-127	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	24-27
29730553-4	2018	The SB Cr3+ conjugate in methanol-water (70:30 v/v) allows quantification of Cr3+ ions with limit of detection 0.44 muM and its self-aggregation in high water fraction facilitates extraction of Cr3+ ions with 95% extraction efficiency.	Water	34-39	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	7-10
29730553-4	2018	The SB Cr3+ conjugate in methanol-water (70:30 v/v) allows quantification of Cr3+ ions with limit of detection 0.44 muM and its self-aggregation in high water fraction facilitates extraction of Cr3+ ions with 95% extraction efficiency.	Water	34-39	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	77-80
29730553-4	2018	The SB Cr3+ conjugate in methanol-water (70:30 v/v) allows quantification of Cr3+ ions with limit of detection 0.44 muM and its self-aggregation in high water fraction facilitates extraction of Cr3+ ions with 95% extraction efficiency.	Water	34-39	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	77-80
29730553-4	2018	The SB Cr3+ conjugate in methanol-water (70:30 v/v) allows quantification of Cr3+ ions with limit of detection 0.44 muM and its self-aggregation in high water fraction facilitates extraction of Cr3+ ions with 95% extraction efficiency.	Water	153-158	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	7-10
28835918-1	2017	The violation of the Stokes-Einstein (SE) relation D ~ (eta/T)-1 between the shear viscosity eta and the translational diffusion constant D at temperature T is of great importance for characterizing anomalous dynamics of supercooled water.	Water	233-238	endothelin receptor type A	Homo sapiens	56-59
29334282-6	2018	The amount of distilled water passed through each dentin disc (muL/min) under a constant pressure was determined.	Water	24-29	tripartite motif containing 37	Homo sapiens	63-66
28835918-1	2017	The violation of the Stokes-Einstein (SE) relation D ~ (eta/T)-1 between the shear viscosity eta and the translational diffusion constant D at temperature T is of great importance for characterizing anomalous dynamics of supercooled water.	Water	233-238	endothelin receptor type A	Homo sapiens	93-96
28835918-3	2017	We provide comprehensive simulation results of the dynamic properties involving eta and D in the TIP4P/2005 supercooled water.	Water	120-125	endothelin receptor type A	Homo sapiens	80-83
28731122-2	2017	Mechanistic investigations show that RhIII(ttp)H, which can be derived from the reaction of [RhII(ttp)]2 with water without a sacrificial reductant, plays an important role in promoting bimetallic reductive elimination to give the hydrogenation product.	Water	110-115	ZFP36 ring finger protein	Homo sapiens	43-46
30383070-2	2018	Among the different genes that are upregulated by hypoxia is carbonic anhydrase IX, which combines carbon dioxide and water to form bicarbonate and hydrogen.	Water	118-123	carbonic anhydrase 9	Homo sapiens	61-82
29808410-6	2018	In the desorption experiments, SM2 released to the overlying water was an order of magnitude greater than TC.	Water	61-66	SM2	Homo sapiens	31-34
29654607-3	2018	We incorporated a representation of HR into the Community Land Model (CLM4.5) and found the new model improved predictions of water, energy, and system-scale carbon fluxes observed by eddy covariance at four seasonally dry yet ecologically diverse temperate and tropical AmeriFlux sites.	Water	126-131	CD300 molecule like family member d	Homo sapiens	70-74
28731122-2	2017	Mechanistic investigations show that RhIII(ttp)H, which can be derived from the reaction of [RhII(ttp)]2 with water without a sacrificial reductant, plays an important role in promoting bimetallic reductive elimination to give the hydrogenation product.	Water	110-115	ZFP36 ring finger protein	Homo sapiens	98-101
28661666-3	2017	Y-shp-MOF-5 exhibits exceptional structural integrity, robustness, and unique humidity-control performance, as confirmed by the large number (thousand) of conducted water vapor adsorption-desorption cycles.	Water	165-170	nuclear receptor subfamily 0 group B member 2	Homo sapiens	2-5
28092075-3	2017	Addition of 20 (3) and 40 (6) mg/L (mg/kg BW) of boron to drinking water significantly increased rat serum IgG concentrations, splenic IFN-gamma and IL-4 expression as well as the number of splenic CD3+, CD4+ and proliferating cell nuclear antigen (PCNA)+ cells.	Water	67-72	interleukin 4	Rattus norvegicus	149-153
29123474-0	2017	Brain Interleukin-1 Facilitates Learning of a Water Maze Spatial Memory Task in Young Mice.	Water	46-51	interleukin 1 complex	Mus musculus	6-19
29044144-2	2017	The stability of this novel gem-diol compound is found owning to the hydrogen bonds with lattice water molecules and electrophilic tetrazolyl groups.	Water	97-102	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	28-31
28807355-0	2017	Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.	Water	19-24	regucalcin	Mus musculus	81-86
28807355-9	2017	Administration of H2-rich water attenuated the CS-induced lung damage in the SMP30-KO mice and reduced the mean linear intercept and destructive index of the lungs.	Water	26-31	regucalcin	Mus musculus	77-82
28906099-4	2017	In this study, one-dimensional (1D) HAp nanostructures with tunable length were synthesized by an oleic acid assisted solvothermal method by adjusting the alcohol/water ratio (eta).	Water	163-168	reticulon 3	Homo sapiens	36-39
28943456-5	2017	In order to investigate if the Nurr1 up-regulation induced by PERM, was associated to the pro-oxidant activity of the pesticide, anti-oxidants as glutathione (GSH), tocotrienols (TOC) and Electrolyzed Reduced Water (ERW) were tested.	Water	209-214	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	31-36
28698029-8	2017	Knockdown of EphA4 using EphA4 siRNA injection intracerebroventricularly (i.c.v) reduced Evans blue extravasation, decreased brain water content, and alleviated neurobehavioral dysfunction after SAH.	Water	131-136	Eph receptor A4	Rattus norvegicus	13-18
28698029-8	2017	Knockdown of EphA4 using EphA4 siRNA injection intracerebroventricularly (i.c.v) reduced Evans blue extravasation, decreased brain water content, and alleviated neurobehavioral dysfunction after SAH.	Water	131-136	Eph receptor A4	Rattus norvegicus	25-30
28636458-12	2017	Field decontamination using dish soap, water, and scrubbing was able to reduce PAH contamination on turnout jackets by a median of 85%.	Water	39-44	phenylalanine hydroxylase	Homo sapiens	79-82
28673740-0	2017	Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia.	Water	53-58	torsin family 1, member A (torsin A)	Mus musculus	23-30
28746744-0	2017	Enzyme-Responsive LipoCEST Agents: Assessment of MMP-2 Activity by Measuring the Intra-liposomal Water 1 H NMR Shift.	Water	97-102	matrix metallopeptidase 2	Homo sapiens	49-54
28809112-6	2017	The NDC-Y-fcu-MOF based sensor exhibited excellent performance for sensing ammonia for simulated breathing system in the presence of the mixture of carbon dioxide and/or humidity (water vapor), with no major alteration in the detection signal.	Water	180-185	lysine acetyltransferase 8	Homo sapiens	14-17
28732164-3	2017	Interlayer water in V2O5 and MnO2 has been shown to improve Mg2+ intercalation kinetics in nonaqueous electrolytes.	Water	11-16	mucin 7, secreted	Homo sapiens	60-63
28732164-11	2017	These results demonstrate that tungsten oxides are potential candidates for Mg2+ cathodes, that in these materials structural water can lead to improved Mg2+ kinetics at the expense of capacity, and that the type of structural water affects stability.	Water	126-131	mucin 7, secreted	Homo sapiens	153-156
28732164-11	2017	These results demonstrate that tungsten oxides are potential candidates for Mg2+ cathodes, that in these materials structural water can lead to improved Mg2+ kinetics at the expense of capacity, and that the type of structural water affects stability.	Water	227-232	mucin 7, secreted	Homo sapiens	153-156
28793192-5	2017	The sorption and diffusion behavior of water and methanol was well described by means of the type II sorption model (BET theory).	Water	39-44	delta/notch like EGF repeat containing	Homo sapiens	117-120
28836758-6	2017	We found that, for controlled in vitro culture at water-PFC interfaces, expression of myogenin, myogenic regulatory factors (MRF) family gene, is remarkably attenuated even when myogenic differentiation was induced by reducing levels of growth factors, although MyoD was expressed at the usual level (MyoD up-regulates myogenin under an elastic and/or viscoelastic environment).	Water	50-55	myogenin	Homo sapiens	86-94
28836758-6	2017	We found that, for controlled in vitro culture at water-PFC interfaces, expression of myogenin, myogenic regulatory factors (MRF) family gene, is remarkably attenuated even when myogenic differentiation was induced by reducing levels of growth factors, although MyoD was expressed at the usual level (MyoD up-regulates myogenin under an elastic and/or viscoelastic environment).	Water	50-55	myogenin	Homo sapiens	319-327
29803395-0	2018	The potential role of thyrotropin-releasing hormone in colonic dysmotility induced by water avoidance stress in rats.	Water	86-91	thyrotropin releasing hormone	Rattus norvegicus	22-51
28666065-1	2017	We describe two water-soluble ruthenium complexes, [1]Cl2 and [2]Cl2 , that photodissociate to release a cytotoxic nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a low dose (21 J cm-2 ) of red light in an oxygen-independent manner.	Water	16-21	nicotinamide phosphoribosyltransferase	Homo sapiens	155-160
29803395-1	2018	OBJECTIVE: This study sought to investigate the effect and underlying mechanism of thyrotrophin releasing hormone (TRH) on colonic contractile disorders induced by chronic water avoidance stress (WAS).	Water	172-177	thyrotropin releasing hormone	Rattus norvegicus	115-118
28874822-2	2017	AS1411, a nucleolin aptamer, is wrapped around water-soluble carbon dots and used as a probe for the detection of several types of cancer cells.	Water	47-52	nucleolin	Homo sapiens	10-19
29897643-8	2018	The CEST MRI results were analyzed using Z-spectra, in which the normalized water signal saturation (Ssat /S0 ) is measured as a function of saturation frequency.	Water	76-81	spermidine/spermine N1-acetyl transferase 1	Mus musculus	101-105
28932620-11	2017	The resulting thioester intermediate (INT1) is converted by water attack on the thioester into a second intermediate, a diol (INT2), which is released by proton abstraction by Cys189.	Water	60-65	fibroblast growth factor 3	Homo sapiens	126-130
30060820-10	2018	Thus, the decrease in AQP1 protein levels in the endothelium and AQP5 in gland ductal cells of irradiated animals may have hindered the removal of water from the lumen of ductal cells, inducing a delay in water absorption and triggering a slight lumen increase.	Water	147-152	aquaporin 1	Rattus norvegicus	22-26
28715873-0	2017	Subcritical water-hydrolyzed fish collagen ameliorates survival of endotoxemic mice by inhibiting HMGB1 release in a HO-1-dependent manner.	Water	12-17	high mobility group box 1	Mus musculus	98-103
31957297-1	2017	A new metal-organic framework (MOF), {Zn(oba)(3-bpdh)0.5 }   2 H2 O (1 Zn; oba=4,4"-oxybis(benzoic acid), 3-bpdh=N,N"-bis(1-pyridine-3-yl-ethylidene)hydrazine), was successfully assembled in a solvothermal system.	Water	63-67	lysine acetyltransferase 8	Homo sapiens	6-36
28433886-5	2017	The lowest and the highest water uptake was observed for the films incorporated with 4%MCM-41NPs and 4%MCM-41-APS-10%MET, respectively.	Water	27-32	SH2B adaptor protein 2	Homo sapiens	103-113
27876637-5	2017	Ghrelin injected into either ventricle reduced both water and 1.8% NaCl intake that was stimulated by AngII.	Water	52-57	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
28813053-2	2017	The Cu(ii)/Cu(i) redox potential of probe 1 (0.14 V vs. NHE) was lower than that of 2 (0.233 V vs. NHE) in water.	Water	107-112	solute carrier family 9 member C1	Homo sapiens	99-102
28696262-8	2017	Examination of available sequence data suggests that Arg-135 may have originated for l-THA-like beta-elimination function in earlier evolutionary variants, and examination of available structural data suggests that a Ser84-H2O-Lys114 hydrogen-bonding network in human serine racemase lowers the pKa of the Ser84re-face base.	Water	223-226	serine racemase	Homo sapiens	268-283
28742347-6	2017	While Mg2+ ions cause a bathochromic shift of the water lone pair orbital, the 3p orbital of the Cl- ions causes an additional peak in the water emission spectrum at around 528 eV.	Water	50-55	mucin 7, secreted	Homo sapiens	6-9
27426435-6	2017	MD simulation of BMP-2 monomer and dimer in water and vacuum environments shows the major contribution of water in structure stabilization.	Water	44-49	bone morphogenetic protein 2	Homo sapiens	17-22
27426435-6	2017	MD simulation of BMP-2 monomer and dimer in water and vacuum environments shows the major contribution of water in structure stabilization.	Water	106-111	bone morphogenetic protein 2	Homo sapiens	17-22
28601707-1	2017	Organometallic carbonyl clusters (OMCC) of group VIII elements are water soluble, bio-compatible and stable high-contrast photoacoustic agents for live cell imaging.	Water	67-72	cytochrome c oxidase subunit 8A	Homo sapiens	49-53
28569366-0	2017	The water avoidance stress induces bladder pain due to a prolonged alpha1A adrenoceptor stimulation.	Water	4-9	adrenoceptor alpha 1A	Homo sapiens	67-87
28587991-1	2017	The influence of controlled water deficit on the phenolic composition and gene expression of VvLAR2, VvMYBPA1, VvMYBPA2 and VvMYB4a in Cabernet Sauvignon grape skins throughout ripening was investigated.	Water	28-33	leucoanthocyanidin reductase 2	Vitis vinifera	93-99
28640997-3	2017	Herein, we present a facile, highly efficient, and versatile "1D to 2D" strategy for preparation of free-standing single-monomer-thick conjugated 2D polymers in water without any aid.	Water	161-166	leiomodin 1	Homo sapiens	61-64
28526196-2	2017	Investigations of PAH air-water exchange are mostly based on observational data obtained using complicated field sampling processes.	Water	26-31	phenylalanine hydroxylase	Homo sapiens	18-21
28526196-3	2017	This study proposes a new approach to improve the estimation of long-term PAH air-water exchange fluxes by using a multivariate regression model to simulate hourly gaseous PAH concentrations.	Water	82-87	phenylalanine hydroxylase	Homo sapiens	74-77
28526196-3	2017	This study proposes a new approach to improve the estimation of long-term PAH air-water exchange fluxes by using a multivariate regression model to simulate hourly gaseous PAH concentrations.	Water	82-87	phenylalanine hydroxylase	Homo sapiens	172-175
28769782-5	2017	Tlr2-/- mice also consumed less food and water, and moved less during the circadian light cycle.	Water	41-46	toll-like receptor 2	Mus musculus	0-4
28740863-1	2017	Bovine cytochrome c oxidase (CcO), a 420-kDa membrane protein, pumps protons using electrostatic repulsion between protons transferred through a water channel and net positive charges created by oxidation of heme a (Fe a ) for reduction of O2 at heme a3 (Fe a3).	Water	145-150	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	7-27
28740863-1	2017	Bovine cytochrome c oxidase (CcO), a 420-kDa membrane protein, pumps protons using electrostatic repulsion between protons transferred through a water channel and net positive charges created by oxidation of heme a (Fe a ) for reduction of O2 at heme a3 (Fe a3).	Water	145-150	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	29-32
27677603-4	2017	The amphiphilic bio-conjugate self-assembles in water into stable spherical nano-particles with a mean diameter of 200nm and CPT substitution percentage of 27%w/w.	Water	48-53	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	125-128
27677603-6	2017	In addition, PEG4-CPT nano-particles are able to load a co-drug, water soluble or non-water soluble doxorubicin and release them simultaneously with the free CPT.	Water	65-70	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	13-21
27677603-6	2017	In addition, PEG4-CPT nano-particles are able to load a co-drug, water soluble or non-water soluble doxorubicin and release them simultaneously with the free CPT.	Water	65-70	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	18-21
27677603-6	2017	In addition, PEG4-CPT nano-particles are able to load a co-drug, water soluble or non-water soluble doxorubicin and release them simultaneously with the free CPT.	Water	86-91	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	13-21
27677603-6	2017	In addition, PEG4-CPT nano-particles are able to load a co-drug, water soluble or non-water soluble doxorubicin and release them simultaneously with the free CPT.	Water	86-91	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	18-21
27677603-8	2017	Thus, in this approach CPT acts in two ways: As the hydrophobic segment that enables self-assembly in water and as a potent anticancer agent.	Water	102-107	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	23-26
29441935-8	2017	Wetting time of both tablets was in the range of 12-21.7 s. Water absorption ratio was 1.41+-0.03 for ODT1 and 1.96+-0.10 for ODT2.	Water	60-65	ectodysplasin A	Homo sapiens	102-112
28358225-3	2017	The formed optimal formulation of AP-M were provided with small size (178.5 nm) and spherical shape at ratio of 4:1 (Soluplus :Pluronic F127), as well as increasing solubility of to 5.61 mg/mL in water which was about 3442-fold compared to that of free AP.	Water	196-201	alanyl aminopeptidase, membrane	Homo sapiens	34-38
28774625-1	2017	Determination of halogen-specific total organic halogen (TOX) is vital for studies of disinfection of waters containing bromide, since total organic bromine (TOBr) is likely to be more problematic than total organic chlorine.	Water	102-108	thymocyte selection associated high mobility group box	Homo sapiens	57-60
28774625-3	2017	The optimised halogen-specific TOX method was validated based on the recovery of model compounds covering different classes of disinfection by-products (haloacetic acids, haloacetonitriles, halophenols and halogenated benzenes) and the recovery of total bromine (mass balance of TOBr and bromide concentrations) during disinfection of waters containing dissolved organic matter and bromide.	Water	335-341	thymocyte selection associated high mobility group box	Homo sapiens	31-34
28774625-8	2017	Excellent recoveries of total bromine (92%-95%) were also obtained from chlorination of a synthetic water containing dissolved organic matter and bromide, demonstrating the validity of the halogen-specific TOX method for TOBr measurement.	Water	100-105	thymocyte selection associated high mobility group box	Homo sapiens	206-209
28774625-9	2017	The halogen-specific TOX method is an important tool to monitor and better understand the formation of halogenated organic compounds, in particular brominated organic compounds, in drinking water systems.	Water	190-195	thymocyte selection associated high mobility group box	Homo sapiens	21-24
28774627-11	2017	These data may form the foundation of novel research to define the major forcing agents of DBP-mediated toxicity in disinfected water and may play an important role in achieving the goal of making safe drinking water better.	Water	128-133	D site-binding protein	Cricetulus griseus	91-94
28774627-11	2017	These data may form the foundation of novel research to define the major forcing agents of DBP-mediated toxicity in disinfected water and may play an important role in achieving the goal of making safe drinking water better.	Water	211-216	D site-binding protein	Cricetulus griseus	91-94
27996090-8	2017	The highest water contact value 123.09  (eta = 25%) indicated a better surface hydrophobicity.	Water	12-17	endothelin receptor type A	Homo sapiens	41-44
28695953-7	2017	Addition of NEt3 attenuated the water and alcohol loss from 5-9 to allow 1H, 13C, 31P, and 11B NMR data to be collected for all the compounds, confirming the determined structures.	Water	32-37	tetraspanin 2	Homo sapiens	12-16
32908434-8	2017	However, these conformation parameters showed low correlation with water-holding capacity, which was determined as thawing and drip loss of the samples.	Water	67-72	DL	Gallus gallus	127-136
28525373-7	2017	CONCLUSIONS: Liquid water metabolic abnormalities and intestine permeability alteration might be the mechanism of IBS by down-regulating AQP1, AQP3 and AQP8 via NF-kappaB pathway.	Water	20-25	aquaporin 1	Rattus norvegicus	137-141
28653842-3	2017	Thermal treatment of [Mg0.74Al0.26(OH)2](SO4)0.1(CO3)0.03 0.62(H2O) 0.04(acetone) prepared by the aqueous miscible organic solvent treatment method (Mg2.84Al-SO4-A AMO-LDH) is shown to yield a mixed metal oxide above 300  C by a combination of thermogravimetric analysis, powder X-ray diffraction (PXRD), BET surface area analysis, and FTIR spectroscopy.	Water	63-66	delta/notch like EGF repeat containing	Homo sapiens	305-308
30108870-5	2017	The issue of solubility was also addressed by the development of water soluble prodrugs of CA-4.	Water	65-70	carbonic anhydrase 4	Homo sapiens	91-95
27986960-5	2017	For thermal water from Ladek-Zdroj (Ladek-Zdroj L-2), significantly elevated doses were observed both for workers (10.8 mSv) and clients (194 muSv).	Water	12-17	immunoglobulin kappa variable 3-15	Homo sapiens	48-51
28411809-2	2017	Here we report one pot solvothermal synthesis of polyethylenimine (PEI) coated CaF2: 1%Er3+, 2%Yb3+ UCNPs with good water-solubility and biocompatibility.	Water	116-121	CCR4-NOT transcription complex subunit 8	Homo sapiens	79-83
28642502-0	2017	Quasi-stabilized hydration layers on muscovite mica under a thin water film grown from humid air.	Water	65-70	MHC class I polypeptide-related sequence A	Homo sapiens	47-51
28513173-3	2017	Here, we provide a complete mechanistic picture of the excited state relaxation of dCyd/5mdCyd in three solvents-water, acetonitrile, and tetrahydrofuran-by combining femtosecond fluorescence experiments, addressing the effect of solvent proticity on the relaxation dynamics of dCyd and 5mdCyd for the first time, and two complementary quantum mechanical approaches (CASPT2/MM and PCM/TD-CAM-B3LYP).	Water	113-118	Cyd	Drosophila melanogaster	83-87
28513173-3	2017	Here, we provide a complete mechanistic picture of the excited state relaxation of dCyd/5mdCyd in three solvents-water, acetonitrile, and tetrahydrofuran-by combining femtosecond fluorescence experiments, addressing the effect of solvent proticity on the relaxation dynamics of dCyd and 5mdCyd for the first time, and two complementary quantum mechanical approaches (CASPT2/MM and PCM/TD-CAM-B3LYP).	Water	113-118	Cyd	Drosophila melanogaster	90-94
33429562-3	2017	Macromonomer is polymerized via olefin metathesis living cyclopolymerization method using the Grubbs-Hoveyda catalyst to produce a water-soluble Dox-Peg-Rcp-Fmoc polymer.	Water	131-136	CGRP receptor component	Homo sapiens	153-156
33429562-6	2017	The newly designed Dox-Peg-Rcp polymer shows nanoaggregation in water.	Water	64-69	CGRP receptor component	Homo sapiens	27-30
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Water	107-112	solute carrier family 51 subunit beta	Rattus norvegicus	181-187
28541290-3	2017	The higher activities in zeolites BEA and FAU than in water are caused by more positive activation entropies that more than offset higher activation enthalpies.	Water	54-59	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	42-45
28482601-9	2017	Selected non water permeable nanoscale coating on PEEK showed strong bioactivity by being viable for human osteoblast (hFOB) and human fibroblast (hGF) cells without toxicity issues.	Water	13-18	hepatocyte growth factor	Homo sapiens	147-150
30060820-10	2018	Thus, the decrease in AQP1 protein levels in the endothelium and AQP5 in gland ductal cells of irradiated animals may have hindered the removal of water from the lumen of ductal cells, inducing a delay in water absorption and triggering a slight lumen increase.	Water	205-210	aquaporin 1	Rattus norvegicus	22-26
28125526-9	2017	MiR-155-transfected mice showed alleviation of inflammation, lower water content in lung tissues, increased number of autophagy bodies, increased expression of microtubule-associated protein 1 light chain 3 (LC3 II/I), reduced expressions of cysteinyl aspartate-specific protease-1 (Caspase-1), and TAB2, and decreased cytokines levels.	Water	67-72	microRNA 155	Mus musculus	0-7
28461473-5	2017	Microperfusion of live renal distal tubules reveals that they are impermeable to water in normal animals but become highly permeable to water in Ildr1 knockout animals whereas paracellular ionic permeabilities in the Ildr1 knockout mouse renal tubules are not affected.	Water	136-141	immunoglobulin-like domain containing receptor 1	Mus musculus	145-150
28461473-7	2017	In cultured renal epithelial cells normally lacking the expression of Ildr1, overexpression of Ildr1 significantly reduces the paracellular water permeability.	Water	140-145	immunoglobulin-like domain containing receptor 1	Mus musculus	95-100
30059171-4	2018	This creates a 1.5 microm thick protection layer composed of Ge, GeOx , Li2 CO3 , LiOH, LiCl, and Li2 O on Li surface that allows stable cycling of Li electrodes both in Li-symmetrical cells and Li-O2 cells, especially in "moist" electrolytes (with 1000-10 000 ppm H2 O) and humid O2 atmosphere (relative humidity (RH) of 45%).	Water	265-269	ATP binding cassette subfamily A member 12	Homo sapiens	72-75
28651550-2	2017	Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked to cooling) but not TRPV1 or TRPA1 (linked to nociception) and tested C3 in subjects with mild forms of dry eye disease.	Water	23-28	transient receptor potential cation channel subfamily M member 8	Homo sapiens	37-42
28651550-2	2017	Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked to cooling) but not TRPV1 or TRPA1 (linked to nociception) and tested C3 in subjects with mild forms of dry eye disease.	Water	23-28	transient receptor potential cation channel subfamily M member 8	Homo sapiens	141-146
28651550-2	2017	Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked to cooling) but not TRPV1 or TRPA1 (linked to nociception) and tested C3 in subjects with mild forms of dry eye disease.	Water	23-28	transient receptor potential cation channel subfamily V member 1	Homo sapiens	175-180
28651550-2	2017	Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked to cooling) but not TRPV1 or TRPA1 (linked to nociception) and tested C3 in subjects with mild forms of dry eye disease.	Water	23-28	transient receptor potential cation channel subfamily A member 1	Homo sapiens	184-189
30046000-2	2018	Dysfunction of the proximal tubule segment can lead to Fanconi renotubular syndrome (FRTS), with major symptoms such as excess excretion of water, glucose, and phosphate in the urine.	Water	140-145	FRTS1	Homo sapiens	85-89
28509528-0	2017	Synthesis of Water-Soluble Ag2S Quantum Dots with Fluorescence in the Second Near-Infrared Window for Turn-On Detection of Zn(II) and Cd(II).	Water	13-18	angiotensin II receptor type 1	Homo sapiens	27-31
28509528-3	2017	We have developed a facile two-step route to synthesize the water-soluble Ag2S QDs, constituting of a green hydrothermal process and followed surface ligands exchange.	Water	60-65	angiotensin II receptor type 1	Homo sapiens	74-78
28406644-11	2017	Finally, in H2O-MeCN mixtures, [3a]PF6 showed selective photosubstitution of l-proline, thus demonstrating the active role played by the solvent on the photoreactivity of this series of complexes.	Water	12-15	sperm associated antigen 17	Homo sapiens	35-38
28540970-3	2017	In this work, a water-ethanol solution spin coating approach has been applied to directly deposit CZTS nanocrystallites on rutile TiO2 nanorods grown on an FTO substrate (TNR) for evaluation in a sensitized solar cell configuration.	Water	16-21	tenascin R	Homo sapiens	171-174
30037108-2	2018	The decomposition of LiPF6 in the electrolyte of lithium-ion batteries produces the reactive PF6, which reacts with the residual water and generates HF.	Water	129-134	sperm associated antigen 17	Homo sapiens	23-26
28695146-7	2017	RESULTS: Glialcam-null mice had early-onset megalencephaly and increased brain water content.	Water	79-84	hepatocyte cell adhesion molecule	Mus musculus	9-17
28695146-10	2017	Glialcam-null astrocytes showed abolished expression of MLC1, reduced expression of the chloride channel ClC-2 and increased expression and redistribution of the water channel aquaporin4.	Water	162-167	hepatocyte cell adhesion molecule	Mus musculus	0-8
27774651-9	2017	Results suggest that in non-acute exposures, basic and neutral organic compounds in the water-soluble fraction of OSPW inhibit activity of P-gp, which suggests that OSPW has the potential to cause adverse effects by chemosensitization.	Water	88-93	glycerol-3-phosphate phosphatase	Oryzias latipes	139-143
29562865-7	2018	During the presence of Dox in the drinking water, plasma GDNF was at a basal level, whereas during the absence of Dox, plasma GDNF was significantly elevated, indicating reliable regulation of therapeutic gene expression.	Water	43-48	glial cell line derived neurotrophic factor	Mus musculus	57-61
28284699-6	2017	The Tgase-treated WPI polymers had a larger particle size (~2.6-fold) than native WPI, which may have reduced coalescence and flocculation in an oil-in-water emulsion system.	Water	152-157	transglutaminase 1	Homo sapiens	4-9
28284699-10	2017	However, the improved emulsifying properties of WPI cross-linked by Tgase may be useful in food processing at higher NaCl concentrations due to the formation of the thicker steric barrier at the oil-water interface.	Water	199-204	transglutaminase 1	Homo sapiens	68-73
28377431-4	2017	Binding ANP or BNP to natriuretic peptide receptor A induces cyclic guanylyl monophosphate as second messenger in the target cells to mediate the following: natriuresis; water diuresis; increasing glomerular filtration rate; decreasing systemic sympathetic activities; plasma volume; cardiac output and blood pressure; and curbing mitoses of heart fibroblasts and hypertrophy of cardiovascular muscle cells.	Water	170-175	natriuretic peptide B	Homo sapiens	15-18
29926723-3	2018	Here, we explore deionized (DI) water as a solution top-gate for field-effect switching of layered semiconductors including SnS2, MoS2, and black phosphorus.	Water	32-37	sodium voltage-gated channel alpha subunit 11	Homo sapiens	124-128
28724101-6	2017	Correlation analysis indicated that the water quality improved at approximately 30% (COD) and 20% (NH-N) of monitoring sites with the reduction of water pollutant emissions from industrial sources.	Water	40-45	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	85-88
29938274-7	2018	The piH-bonded water molecules are found to reorient through large-amplitude angular jumps where the jump-angle amplitude increases at higher temperatures and lower densities.	Water	15-20	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	4-7
29123324-7	2017	SLC-off Landsat 7 imagery was integrated by applying a customized interpolation that mapped water in missing data gaps with 99% user"s accuracy.	Water	92-97	C-C motif chemokine ligand 21	Homo sapiens	0-3
28587495-1	2017	Manganese superoxide dismutase (MnSOD) is a mitochondrial-resident enzyme that reduces superoxide to hydrogen peroxide (H2O2), which can be further reduced to water by glutathione peroxidase (GPX1).	Water	159-164	superoxide dismutase 2	Homo sapiens	0-30
28587495-1	2017	Manganese superoxide dismutase (MnSOD) is a mitochondrial-resident enzyme that reduces superoxide to hydrogen peroxide (H2O2), which can be further reduced to water by glutathione peroxidase (GPX1).	Water	159-164	superoxide dismutase 2	Homo sapiens	32-37
29938274-9	2018	Water molecules in the axial conical shells are also found to diffuse at a faster rate than bulk molecules due to the relatively weaker benzene-water piH-bonding interactions in the axial region of the hydration shell.	Water	0-5	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	150-153
30013886-2	2018	In the case of SiGe, which constitutes the most challenging process, we show the reliability of the SC1 chemical solution (NH4OH/H2O2/H2O) with its slow etch rate, stoichiometry conservation and low roughness generation.	Water	129-132	transcription factor 19	Homo sapiens	100-103
28371293-0	2017	GaP/GaNP Heterojunctions for Efficient Solar-Driven Water Oxidation.	Water	52-57	minichromosome maintenance complex component 3 associated protein	Homo sapiens	4-8
28371293-1	2017	The growth and characterization of an n-GaP/i-GaNP/p+ -GaP thin film heterojunction synthesized using a gas-source molecular beam epitaxy (MBE) method, and its application for efficient solar-driven water oxidation is reported.	Water	199-204	minichromosome maintenance complex component 3 associated protein	Homo sapiens	46-50
28371293-4	2017	The photocurrent at the water oxidation potential (1.23 V vs RHE) is 1.46 and 7.26 mA cm-2 for the coated n-GaP and n-GaP/i-GaNP/p+ -GaP photoanodes, respectively.	Water	24-29	minichromosome maintenance complex component 3 associated protein	Homo sapiens	124-128
28371293-7	2017	The high low-bias performance and broad absorption of the wide-bandgap GaP/GaNP heterojunctions render them as a promising photoanode material for tandem photoelectrochemical (PEC) cells to carry out overall solar water splitting.	Water	214-219	minichromosome maintenance complex component 3 associated protein	Homo sapiens	75-79
28382338-2	2017	The results show that H2O and CO molecules were physisorbed on the S-vacancy SnS2 monolayer, whereas NH3, NO, and NO2 molecules were chemisorbed on the S-vacancy SnS2 monolayer via strong covalent bonds.	Water	22-25	sodium voltage-gated channel alpha subunit 11	Homo sapiens	77-81
28368432-2	2017	Our result shows that the computed binding free energies for five CDK2-ligand complexes using the IE method have a significantly linear correlation with the experimentally measured values with a correlation coefficient of 0.98 in consideration of the bridging water under the PPC force field.	Water	260-265	cyclin dependent kinase 2	Homo sapiens	66-70
29911863-4	2018	Photocatalytic experiments demonstrate that this Cu(I)-MOF exhibits high reactivity for reduction of Cr(VI) in water, with 95% Cr(VI) converting to Cr(III) in 10 min by using MeOH as scavenger under visible-light illumination.	Water	111-116	lysine acetyltransferase 8	Homo sapiens	55-58
29965130-3	2017	The results showed that the total concentrations of measured water-soluble inorganic ions were (8.91+-7.27) and (11.34+-9.37) mug m-3 in PM2.1 and PM2.1-9, respectively.	Water	61-66	KDEL endoplasmic reticulum protein retention receptor 1	Homo sapiens	147-154
28822153-2	2017	The results showed that water in Paeoniae Radix Alba fresh products was major of free water, and in the boiling process, the content of free water increased whereas the content of bound water declined.	Water	24-29	afamin	Homo sapiens	48-52
28822153-2	2017	The results showed that water in Paeoniae Radix Alba fresh products was major of free water, and in the boiling process, the content of free water increased whereas the content of bound water declined.	Water	86-91	afamin	Homo sapiens	48-52
28822153-2	2017	The results showed that water in Paeoniae Radix Alba fresh products was major of free water, and in the boiling process, the content of free water increased whereas the content of bound water declined.	Water	86-91	afamin	Homo sapiens	48-52
28822153-2	2017	The results showed that water in Paeoniae Radix Alba fresh products was major of free water, and in the boiling process, the content of free water increased whereas the content of bound water declined.	Water	86-91	afamin	Homo sapiens	48-52
29845241-0	2018	Water-soluble nano-pearl powder promotes MC3T3-E1 cell differentiation by enhancing autophagy via the MEK/ERK signaling pathway.	Water	0-5	midkine	Mus musculus	102-105
28231498-7	2017	Due to the presence of highly water-soluble polymer chains, dispersion of PEPn Na NPs in aqueous media was stable for at least 1 week.	Water	30-35	alanyl aminopeptidase, membrane	Homo sapiens	74-78
28231498-11	2017	Both PEPn Na NPs and PEG NPs adsorbed well onto HAp microparticles in distilled water with binding equilibrium constants (KHAp) for PEPn Na NPs and PEG NPs of 3.6x106 and 7.9x106, respectively.	Water	80-85	alanyl aminopeptidase, membrane	Homo sapiens	5-9
27709349-9	2017	Only one protein, far upstream element binding protein 2 (FUBP2), was similarly downregulated in the epidermis after bathing in CO2-enriched water with both techniques.	Water	141-146	KH-type splicing regulatory protein	Rattus norvegicus	18-56
27709349-9	2017	Only one protein, far upstream element binding protein 2 (FUBP2), was similarly downregulated in the epidermis after bathing in CO2-enriched water with both techniques.	Water	141-146	KH-type splicing regulatory protein	Rattus norvegicus	58-63
27709349-10	2017	Low FUBP2 expression was associated with low c-Myc immune-expression in keratinocytes.Long-term bathing in CO2-enriched water showed a cellular protein response of epithelial cells in the epidermis which was detectable by two different methods.	Water	120-125	KH-type splicing regulatory protein	Rattus norvegicus	4-9
29875071-4	2018	Studies, primarily using the Salmonella mutagenicity assay, have continued to show that chlorination or chloramination of source waters results in finished, tap, or swimming pool/spa water that is more mutagenic than the original source water.	Water	129-134	surfactant protein A1	Homo sapiens	179-182
28362358-3	2017	A distal water molecule located about 6.1 A away from the attacking amine plays as a proton acceptor and results in a charge-separated intermediate that is stabilized by the N terminus of L27 and the A-site A76 5"-phosphate.	Water	9-14	ribosomal protein L27	Homo sapiens	188-191
28167137-6	2017	Catecholaminergic deletion of Rictor increases water, sucrose, and morphine intake but not preference in a two-bottle choice assay in stress-naive mice, and these effects are maintained after stress.	Water	47-52	RPTOR independent companion of MTOR, complex 2	Mus musculus	30-36
28167137-7	2017	VTA-specific knockout of Rictor increases water and sucrose intake after physical CSDS, but does not alter consummatory behavior in the absence of stress.	Water	42-47	RPTOR independent companion of MTOR, complex 2	Mus musculus	25-31
29875071-4	2018	Studies, primarily using the Salmonella mutagenicity assay, have continued to show that chlorination or chloramination of source waters results in finished, tap, or swimming pool/spa water that is more mutagenic than the original source water.	Water	183-188	surfactant protein A1	Homo sapiens	179-182
28468242-1	2017	Water-fed photo-electrolysis cells equipped with perfluorosulfonic acid (Nafion  115) and quaternary ammonium-based (Fumatech  FAA3) ion exchange membranes as separator for hydrogen and oxygen evolution reactions were investigated.	Water	0-5	transforming growth factor beta receptor 2	Homo sapiens	127-131
29733206-6	2018	Thus, sharp increase in the values of TDelta SA and Delta HA was demonstrated for the betaine-based solutions with 30-40 wt % water.	Water	126-131	spen family transcriptional repressor	Homo sapiens	6-11
28252939-1	2017	A copper-based metal-organic framework (MOF), [Cu3(TMA)2(H2O)3]n (also known as HKUST-1, where TMA stands for trimesic acid), and its TiO2 nanocomposites were directly synthesized in micrometer-sized droplets via a rapid aerosol route for the first time.	Water	57-60	lysine acetyltransferase 8	Homo sapiens	15-45
29715036-1	2018	Carbonic anhydrase IX (CAIX) is a membrane-spanning zinc metalloenzyme that catalyzes the reversible consumption of CO2 and water to form H+ + HCO3-.	Water	124-129	carbonic anhydrase 9	Homo sapiens	0-21
28251928-4	2017	IFIT1 forms a water-filled, positively charged RNA-binding tunnel with a separate hydrophobic extension that unexpectedly engages the cap in multiple conformations (syn and anti) giving rise to a relatively plastic and nonspecific mode of binding, in stark contrast to eIF4E.	Water	14-19	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	0-5
28271890-4	2017	CD14 in GB implicit water model (Igb5) was found mostly in an opened conformation with average circularity of 0.39 +- 0.16 and a slight bend with average biplanar angle of 145.5 +- 16.0 .	Water	20-25	CD14 molecule	Homo sapiens	0-4
28271890-5	2017	In contrast, CD14 in TIP3P explicit water solvation is significantly twisted with average circularity of 0.16 +- 0.10, while 29.1% are ODCs.	Water	36-41	CD14 molecule	Homo sapiens	13-17
28271890-6	2017	In addition, classification of CD14 conformations using a Gaussian mixture model (GMM) shows that 85.0% of all CD14 in implicit water at 300 K correspond to the elliptical conformation, in contrast to 82.3% in twisted form in explicit water.	Water	128-133	CD14 molecule	Homo sapiens	31-35
28271890-6	2017	In addition, classification of CD14 conformations using a Gaussian mixture model (GMM) shows that 85.0% of all CD14 in implicit water at 300 K correspond to the elliptical conformation, in contrast to 82.3% in twisted form in explicit water.	Water	128-133	CD14 molecule	Homo sapiens	111-115
28124814-0	2017	High Redox Capacity of Al-Doped La1-x Srx MnO3-delta Perovskites for Splitting CO2 and H2 O at Mn-Enriched Surfaces.	Water	87-91	sulfiredoxin 1	Homo sapiens	38-41
29715036-1	2018	Carbonic anhydrase IX (CAIX) is a membrane-spanning zinc metalloenzyme that catalyzes the reversible consumption of CO2 and water to form H+ + HCO3-.	Water	124-129	carbonic anhydrase 9	Homo sapiens	23-27
28325097-8	2018	Our multivariate Cox Proportional Hazard model yielded two main risk factors for regaining water swallowing function: the number of medical tubes such as catheters at admission to the post-acute department (adjusted hazard ratio [HR] = 1.282; 95% confidence interval [CI]: 1.099-1.495) and the time until weaning from the respirator in days (adjusted HR =1.02 per day; 95%CI: 0.998 to 1.008).	Water	91-96	cytochrome c oxidase subunit 8A	Homo sapiens	17-20
28287712-2	2017	epsilon-PL, which possesses multiple amino groups, is highly soluble in water, where it forms the antimicrobial polycationic chain (PLn+).	Water	72-77	phospholamban	Homo sapiens	132-135
28287712-4	2017	Here, we report on the preparation and availability of a water-insoluble complex formed with PLn+ and an anionic surfactant, bis(2-ethylhexyl) sulfosuccinate (BEHS-, is also commercialized as AOT) anion.	Water	57-62	phospholamban	Homo sapiens	93-96
28287712-5	2017	The PLn+/BEHS--complex, which is soluble in organic solvents, was successfully used as a coating material for a cellulose acetate membrane to create a water-resistant antimicrobial membrane.	Water	151-156	phospholamban	Homo sapiens	4-7
28257013-2	2017	Despite the presence of these species within its pores, JDF-2 can hydrate upon exposure to atmospheric moisture to give AlPO-53(A), an isostructural material whose crystal structure contains one molecule of H2O per formula unit.	Water	207-210	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Homo sapiens	56-61
29266331-5	2018	The CYP19-RT-LAMP assay rapidly identified the LPS-induced downregulation of the CYP19 gene within 30 min at 63 C in a water bath.	Water	119-124	lysosomal associated membrane protein 3	Homo sapiens	13-17
28034894-10	2017	Plasma angiopoietin-1 levels significantly increased at 25 minutes after 500 ml water ingestion compared to those at baseline.	Water	80-85	angiopoietin 1	Homo sapiens	7-21
28034894-13	2017	CONCLUSIONS: The hypo-osmotic stimulus of water ingestion increases angiopoietin-1 secretion and subsequently activates the Tie-2/Akt/eNOS signaling pathway in RBCs, thereby revealing a novel biological mechanism simultaneously occurring with the osmopressor response.	Water	42-47	angiopoietin 1	Homo sapiens	68-82
28209058-10	2017	After glucose loading, the nuclear export of glucokinase was significantly increased in the RSS group compared to the water group.	Water	118-123	glucokinase	Rattus norvegicus	45-56
28034894-13	2017	CONCLUSIONS: The hypo-osmotic stimulus of water ingestion increases angiopoietin-1 secretion and subsequently activates the Tie-2/Akt/eNOS signaling pathway in RBCs, thereby revealing a novel biological mechanism simultaneously occurring with the osmopressor response.	Water	42-47	TEK receptor tyrosine kinase	Homo sapiens	124-129
29974703-3	2018	The results showed that the soil water storage (0-100 cm) at 300 and 450 kg N hm-2 in middle and late growing period of maize was significantly increased by 10.1% and 9.0%.	Water	33-38	Putative anthocyanidin reductase	Zea mays	78-82
28261150-1	2017	A synthetic peptide with antisecretory activity, antisecretory factor (AF)-16, improves injury-related deficits in water and ion transport and decreases intracranial pressure after experimental cold lesion injury and encephalitis although its role in traumatic brain injury (TBI) is unknown.	Water	115-120	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Rattus norvegicus	49-69
28380032-1	2017	Aquaporin 1 (AQP1) is a member of the transmembrane water channel family of proteins with special structural features, and two AQP1 paralogous genes (aqp1aa and aqp1ab) are reported in teleosts.	Water	52-57	aquaporin-1	Cynoglossus semilaevis	0-11
28380032-1	2017	Aquaporin 1 (AQP1) is a member of the transmembrane water channel family of proteins with special structural features, and two AQP1 paralogous genes (aqp1aa and aqp1ab) are reported in teleosts.	Water	52-57	aquaporin-1	Cynoglossus semilaevis	13-17
28380032-1	2017	Aquaporin 1 (AQP1) is a member of the transmembrane water channel family of proteins with special structural features, and two AQP1 paralogous genes (aqp1aa and aqp1ab) are reported in teleosts.	Water	52-57	aquaporin-1	Cynoglossus semilaevis	127-131
29722987-0	2018	Interaction of Myelin Basic Protein with Myelin-like Lipid Monolayers at Air-Water Interface.	Water	77-82	myelin basic protein	Homo sapiens	15-35
28220996-5	2017	As a result of the nanostructuring and shortened charge collection distance, the nanotube photoanode shows a greatly improved PEC water oxidation activity, exhibiting a photocurrent density of 1.5 mA cm-2 at 1.23 V (vs. reversible hydrogen electrode, RHE), which is the highest among hematite nanotube photoanodes without co-catalysts.	Water	130-135	factor interacting with PAPOLA and CPSF1	Homo sapiens	251-254
29722994-2	2018	The hydrophilic beta-Tg monolayer separated the bilayer from the gold substrate and created a water-rich spacer region, which better represents natural cell membranes.	Water	94-99	pro-platelet basic protein	Homo sapiens	16-23
28093242-9	2017	Moreover, colonocytic ZnR/GPR39 and KCC1 reduce water loss during diarrhea and may therefore serve as effective drug targets.	Water	48-53	G protein-coupled receptor 39	Mus musculus	26-31
28106394-6	2017	In water, FeL1-MEPE forms a viscous gel at 20  C (c = 8 mM).	Water	3-8	matrix extracellular phosphoglycoprotein	Homo sapiens	15-19
29861476-4	2018	Wild-type (WT) and IDH2 knockout (KO) mice were treated with either water or 34% fructose water over six weeks.	Water	68-73	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	19-23
28088105-4	2017	The present work aims to evaluate the photodynamic potential of hydro-alcoholic extract from Tectona grandis LF leaves (TGE) and the same extract prepared as the oil-water nanoemulsion (TGE-NE) against melanoma B16 F10 cells.	Water	166-171	transglutaminase 3, E polypeptide	Mus musculus	186-189
28093242-9	2017	Moreover, colonocytic ZnR/GPR39 and KCC1 reduce water loss during diarrhea and may therefore serve as effective drug targets.	Water	48-53	solute carrier family 12, member 4	Mus musculus	36-40
29797541-13	2018	The BBB score, spinal cord water content, and BSCB destruction were also ameliorated by MANF treatment.	Water	27-32	mesencephalic astrocyte-derived neurotrophic factor	Rattus norvegicus	88-92
28337713-11	2017	In rats fed with high-fructose water to induce mild hypertension, 4-week treatment with recombinant FGF21 led to normalization of systolic blood pressure and improved serum lipid profile.	Water	31-36	fibroblast growth factor 21	Rattus norvegicus	100-105
28193331-0	2017	Colorimetric enumeration of bacterial contamination in water based on beta-galactosidase gold nanoshell activity.	Water	55-60	galactosidase beta 1	Homo sapiens	70-88
27960107-3	2017	Conditional depletion of Rheb selectively in the forebrain of mice obtained from crossing Rhebf/f and CamKIICre results in spontaneous signs of age-related memory loss, that is, spatial memory deficits (T-maze, Morris water maze) without affecting locomotor (open-field test), anxiety-like (elevated plus maze), or contextual fear conditioning functions.	Water	218-223	Ras homolog enriched in brain	Mus musculus	25-29
29881721-4	2018	The interaction of MgGa mixed oxides with pure water resulted in reconstruction of the HTC structure already after 15 s of the rehydration with maximum crystallinity achieved after 60 s. TGA-MS experiments proved a substantial decrease in carbonates in all rehydrated samples compared with their as-prepared counterparts.	Water	47-52	T-box transcription factor 1	Homo sapiens	187-190
28258339-6	2017	The concentrations of COD, BOD5, and chlorides (Cl) of surface water samples increased by 12.3-105.7 times.	Water	63-68	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	22-25
28166210-0	2017	A water-mediated allosteric network governs activation of Aurora kinase A.	Water	2-7	aurora kinase A	Homo sapiens	58-73
29706066-0	2018	Interface Engineering of Monolayer MoS2/GaN Hybrid Heterostructure: Modified Band Alignment for Photocatalytic Water Splitting Application by Nitridation Treatment.	Water	111-116	gigaxonin	Homo sapiens	40-43
28222316-7	2017	These potent cell-permeable and water-soluble CYP1B1 inhibitors are likely to have useful roles in the treatment of cancer, glaucoma, ischemia and obesity.	Water	32-37	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	46-52
27836341-4	2017	The efficiency of the three surfactants used (CTAB, TRITON X-100 and SDS) to retard the evaporation rate of SO2 and DMS from water was estimated by the decrease of the kc values in the presence of the three surfactants, compared to those in the absence of surfactants.	Water	125-130	serine dehydratase	Homo sapiens	52-72
29780024-5	2018	In human alveolar macrophages (AM) in vitro, the exposure to water-soluble tobacco smoke components (WTC) enhanced IL-26 gene and protein.	Water	61-66	interleukin 26	Homo sapiens	115-120
27822596-0	2017	Investigation of the prion protein gene (PRNP) polymorphisms in Anatolian, Murrah, and crossbred water buffaloes (Bubalus bubalis).	Water	97-102	major prion protein	Bubalus bubalis	41-45
28170260-5	2017	As a demonstration, SDS was first applied to maltodextrin binding protein (MBP) in explicit water to reproduce structural transitions between the open and closed states of MBP.	Water	92-97	myelin basic protein	Homo sapiens	45-73
28170260-5	2017	As a demonstration, SDS was first applied to maltodextrin binding protein (MBP) in explicit water to reproduce structural transitions between the open and closed states of MBP.	Water	92-97	myelin basic protein	Homo sapiens	75-78
29634249-5	2018	As a result, a photocurrent approximately 10 times larger than that for a conventional powder-based photoanode is obtained, which indicates the potential of (GaN)1- x(ZnO) x nanowires in the preparation of superior photoanodes for enhanced water splitting.	Water	240-245	gigaxonin	Homo sapiens	158-163
28272461-7	2017	For water-limited ecosystems where GPP are strongly dependent of EVI and EVI are sensitive to precipitation, parameter optimization has limited effects.	Water	4-9	Wnt ligand secretion mediator	Homo sapiens	65-68
28272461-7	2017	For water-limited ecosystems where GPP are strongly dependent of EVI and EVI are sensitive to precipitation, parameter optimization has limited effects.	Water	4-9	Wnt ligand secretion mediator	Homo sapiens	73-76
27956191-8	2017	In conclusion, addition of large amount of excipients, especially water soluble ones in Polyox  based ADF tablets increase the risk of abuse by various routes of administration.	Water	66-71	destrin, actin depolymerizing factor	Homo sapiens	102-105
28100489-0	2017	TALE-induced bHLH transcription factors that activate a pectate lyase contribute to water soaking in bacterial spot of tomato.	Water	84-89	probable pectate lyase P18	Solanum lycopersicum	64-69
29634249-6	2018	It is anticipated that the water-splitting capability of (GaN)1- x(ZnO) x nanowire can be further increased through alignment control for enhanced visible light absorption and reduction of charge transfer resistance.	Water	27-32	gigaxonin	Homo sapiens	58-63
29864887-4	2018	The DAC is kept under inert gas overpressure during the whole process, in order to avoid contamination from atmospheric O2, CO2, and H2O.	Water	133-136	arylacetamide deacetylase	Homo sapiens	4-7
28039837-3	2017	The crystal structure of a potent inhibitor bound to the active CDK2/cyclin A complex revealed that the biphenyl substituent at position 5 of the pyrazolo[1,5-a]pyrimidine scaffold was located in a previously unexplored pocket and that six water molecules resided in the active site.	Water	240-245	cyclin dependent kinase 2	Homo sapiens	64-68
28117969-2	2017	Herein, we first report an oxygen-evolving cobalt-citrate metal-organic framework (MOF, UTSA-16) for highly efficient electrocatalytic water oxidation.	Water	135-140	lysine acetyltransferase 8	Homo sapiens	58-95
29339227-3	2018	The ligand exhibits colorimetric and fluorometric sensing of Zn2+ and Mg2+ ions in semi-aqueous medium (DMSO-H2O).	Water	109-112	mucin 7, secreted	Homo sapiens	70-73
26798062-1	2017	The membrane water channel aquaporin (AQP) family is composed of 13 isoforms in mammals, eight of which are reportedly expressed in the kidney: AQP1, 2, 3, 4, 6, 7, 8, and 11.	Water	13-18	aquaporin 1	Mus musculus	144-174
28496972-3	2017	The HO  and HO2  originating from both Fenton"s reagent and VUV photolysis of water were identified with suitable radical scavengers.	Water	78-83	heme oxygenase 2	Homo sapiens	12-15
29656344-3	2018	This river receives water from a rich karst aquifer when crossing Cib Gorge.	Water	20-25	calcium and integrin binding 1	Homo sapiens	66-69
28001352-4	2017	Compared with GO membrane, these MOF@GO membranes combine the unique properties of MOF and GO and thus have significant enhancements of pervaporation (PV) permeation flux and separation factor simultaneously for ethyl acetate/water mixtures (98/2, w/w) through the PV process, which are also superior to the reported other kinds of membranes.	Water	226-231	lysine acetyltransferase 8	Homo sapiens	33-36
28001352-4	2017	Compared with GO membrane, these MOF@GO membranes combine the unique properties of MOF and GO and thus have significant enhancements of pervaporation (PV) permeation flux and separation factor simultaneously for ethyl acetate/water mixtures (98/2, w/w) through the PV process, which are also superior to the reported other kinds of membranes.	Water	226-231	lysine acetyltransferase 8	Homo sapiens	83-86
28001352-5	2017	Especially, for MOF@GO-0.3 membrane (corresponding MOF loading: 23.08 wt %), the increments are 159% and 244%, respectively, at 303 K, and the permeate water content can reach as high as 99.5 wt % (corresponding separation factor, 9751) with a high permeation flux of 2423 g m-2 h-1.	Water	152-157	lysine acetyltransferase 8	Homo sapiens	16-19
28001352-5	2017	Especially, for MOF@GO-0.3 membrane (corresponding MOF loading: 23.08 wt %), the increments are 159% and 244%, respectively, at 303 K, and the permeate water content can reach as high as 99.5 wt % (corresponding separation factor, 9751) with a high permeation flux of 2423 g m-2 h-1.	Water	152-157	lysine acetyltransferase 8	Homo sapiens	51-54
26462440-7	2017	Consistent with these data, upregulation of the water channel aquaporin 3 (AQP3) mRNA was observed in blastocysts supplemented with 1.25% OF compared with C- and C+.	Water	48-53	aquaporin 3	Bos taurus	75-79
28077210-2	2017	Here, we analyzed 16 PAH occurrences in water, suspended particulate matter (SPM), and sediment monthly for a year in the Maozhou River mainstream (Shenzhen, South China).	Water	40-45	phenylalanine hydroxylase	Homo sapiens	21-24
29632404-4	2018	Although there have been many studies on DBP formation in swimming pools, the role of organic matter derived from herbal medicines applied in herbal spa water has been largely neglected.	Water	153-158	surfactant protein A1	Homo sapiens	149-152
28077210-3	2017	Monthly rainfall positively correlated with both total PAH concentrations in filtered water (water PAHs) and SPM.	Water	86-91	phenylalanine hydroxylase	Homo sapiens	55-58
29632404-5	2018	Accordingly, the present study investigated the effect of herbal medicines on the formation of trihalomethanes (THMs) in simulated herbal spa water.	Water	142-147	surfactant protein A1	Homo sapiens	138-141
29504394-5	2018	A key feature of the [Ru(bpy)3](PF6)2-catalyzed method is the use of ascorbic acid as reductive quencher in a neutral, buffered, two-phase acetonitrile/water mixture, granting fast and highly selective deprotection for all presented examples.	Water	152-157	sperm associated antigen 17	Homo sapiens	32-35
28034658-11	2017	CONCLUSIONS: RSG water-extracts had protective effects against GM-induced kidney injury in rats, and its mechanism of action was related to oxidative stress-induced apoptosis by inhibiting caspase-3 activation.	Water	17-22	caspase 3	Rattus norvegicus	189-198
27916520-0	2017	Water-Bridge Mediates Recognition of mRNA Cap in eIF4E.	Water	0-5	eukaryotic translation initiation factor 4E	Homo sapiens	49-54
29445781-1	2018	The enzyme catechol-O-methyltransferase (COMT) has water soluble (S-COMT) and membrane associated (MB-COMT), bitopic, isoforms.	Water	51-56	catechol-O-methyltransferase	Homo sapiens	11-39
27544874-1	2017	Facilitatory and inhibitory mechanisms in the central nucleus of the amygdala (CeA) and the lateral parabrachial nucleus (LPBN), respectively, are important for the control of sodium and water intake.	Water	187-192	carcinoembryonic antigen gene family 4	Rattus norvegicus	79-82
27544874-2	2017	Here we investigated the importance of the opioid mechanisms in the CeA for water and 0.3M NaCl intake in euhydrated or hyperosmotic rats treated with injections of muscimol (GABAA agonist) or moxonidine (alpha2 adrenergic/imidazoline agonist) into the LPBN, respectively.	Water	76-81	carcinoembryonic antigen gene family 4	Rattus norvegicus	68-71
28104434-10	2017	All together, the food and water intake effects of opiorphin may be due to the protection of the endogenous angiotensin and opioid peptides from degradation by NEP or APN.	Water	27-32	membrane metallo endopeptidase	Mus musculus	160-163
28107010-10	2017	The HBP water and united-atom n-alkane models underestimate water content in the n-alkane-rich phase; this underestimation is likely due to the neglect of electrostatic and induction energies in the united-atom model.	Water	8-13	heme binding protein 1	Homo sapiens	4-7
29445781-1	2018	The enzyme catechol-O-methyltransferase (COMT) has water soluble (S-COMT) and membrane associated (MB-COMT), bitopic, isoforms.	Water	51-56	catechol-O-methyltransferase	Homo sapiens	41-45
28107010-10	2017	The HBP water and united-atom n-alkane models underestimate water content in the n-alkane-rich phase; this underestimation is likely due to the neglect of electrostatic and induction energies in the united-atom model.	Water	60-65	heme binding protein 1	Homo sapiens	4-7
29564896-1	2018	Two water-soluble [Au(9 N-adeninate)(PR3)] complexes (PR3 = PMe3 (1); PTA (3)) were synthesized by the coordination of the respective cationic [Au(PR3)]+ fragment to the 9 N position of the adeninate anion.	Water	4-9	proteinase 3	Homo sapiens	37-40
28427307-3	2018	The total binding enthalpy energies have been obtained by MM-PBSA thermodynamic computations and the favorability of p32.LyP-1 complex in water has been shown by explicit water MD computations.	Water	138-143	inhibitor of growth family member 2	Homo sapiens	117-120
27619973-7	2017	The main resonance centred at g=1.975 indicated that the majority of Cr3+ occupied the interlayer region as [Cr(H2O)6]3+.	Water	112-115	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	69-72
27619973-8	2017	The substitution of Ca2+ by Cr3+ also greatly affected the vibration of the hydrogens associate to water, ranged from 3500 to 2600cm-1 in FTIR.	Water	99-104	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	28-31
28451182-5	2017	A "composite base" consisting of Ser73, Glu99, a bridging water molecule, and GTP was found to activate the nucleophilic water, thus disclosing the complex nature of the general base in hGBP1.	Water	58-63	guanylate binding protein 1	Homo sapiens	186-191
28451182-5	2017	A "composite base" consisting of Ser73, Glu99, a bridging water molecule, and GTP was found to activate the nucleophilic water, thus disclosing the complex nature of the general base in hGBP1.	Water	121-126	guanylate binding protein 1	Homo sapiens	186-191
28451182-7	2017	The subsequent GDP hydrolysis in hGBP1 was also found to follow a water-mediated proton shuttle mechanism.	Water	66-71	guanylate binding protein 1	Homo sapiens	33-38
28451182-8	2017	It is expected that the proton shuttle mechanisms unravelled for hGBP1 apply to many classes of GTPases/ATPases that possess an optimally-arranged hydrogen bonding network, which connects the catalytic water to a proton acceptor.	Water	202-207	guanylate binding protein 1	Homo sapiens	65-70
28427307-3	2018	The total binding enthalpy energies have been obtained by MM-PBSA thermodynamic computations and the favorability of p32.LyP-1 complex in water has been shown by explicit water MD computations.	Water	171-176	inhibitor of growth family member 2	Homo sapiens	117-120
27788633-7	2017	When both the water and light conditions were matched to those at the supplier"s facility, we observed a further reduction in adrenal weight, increased thymus weight, and decreased pro-inflammatory cytokine secretion of isolated and anti-CD3/28-stimulated mesenteric lymph node cells.	Water	14-19	CD3 antigen, epsilon polypeptide	Mus musculus	238-241
27976525-3	2017	The electrocatalyst oxidized water with a turnover frequency (TOF) of (0.2+-0.1) s-1 at 1.71 V versus the normal hydrogen electrode (NHE) in buffered solution (pH~7) and exhibited structural and electrochemical stability.	Water	29-34	solute carrier family 9 member C1	Homo sapiens	133-136
31352939-5	2018	The p-MS/CA could significantly accelerate water absorption and block off the damaged tissue, and thereby efficiently promoted platelet and plasma protein adhesion, enhanced wound adherence, facilitated the contact activation pathway of coagulation cascade with desirable hemostasis.	Water	43-48	proline rich protein BstNI subfamily 1	Homo sapiens	4-8
28098324-1	2017	Polar solvents like water support the bulk dissociation of themselves and their solutes into ions, and the re-association of these ions into neutral molecules in a dynamic equilibrium, e.g., H2O2   H+ + HO2-.	Water	20-25	heme oxygenase 2	Homo sapiens	203-206
27923288-8	2017	Western blotting showed expression in the adrenal of P450scc (CYP11A1), the first rate-limiting enzyme in the synthesis of steroids, was increased 4 h after water immersion restraint stress or LPS treatment in WT mice, but was conversely decreased in TLR4-/- mice after either stressor.	Water	157-162	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	53-60
27923288-8	2017	Western blotting showed expression in the adrenal of P450scc (CYP11A1), the first rate-limiting enzyme in the synthesis of steroids, was increased 4 h after water immersion restraint stress or LPS treatment in WT mice, but was conversely decreased in TLR4-/- mice after either stressor.	Water	157-162	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	62-69
29601621-2	2018	Previous comparative skin explant studies demonstrated greater efficacy of RHA serum than topical non-crosslinked high or low molecular weight hyaluronic acid in decreasing trans-epidermal water loss, increasing epidermal hydration, and improving corneocyte microstructure.	Water	189-194	HCL2	Homo sapiens	75-78
27966855-0	2016	MOF-Derived Noble Metal Free Catalysts for Electrochemical Water Splitting.	Water	59-64	lysine acetyltransferase 8	Homo sapiens	0-3
27942632-1	2016	By using Gd2O3, propanedioic acid (H2pda) and oxalic acid (H2ox), a new Gd-based metal-organic framework (MOF) [Gd(pda)(ox)0.5(H2O)2]n (1) has been successfully constructed and structurally characterized.	Water	127-130	lysine acetyltransferase 8	Homo sapiens	81-110
27882370-6	2016	In 3T3-L1 cells, a water extract (WAF) and 70% EtOH extract (EtAF) of Arctii Fructus significantly inhibited adipogenesis and suppressed the expression of proliferator-activated receptor gamma and CCAAT/enhancer-binding protein alpha.	Water	19-24	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	155-233
27832996-6	2016	Results showed that: Ecto-5"-nucleotidase activity decreased in methimazole/water group and the treatment with quercetin 25mg/kg decreased NTPDase, 5"-nucleotidase and adenosine deaminase activities.	Water	76-81	5' nucleotidase, ecto	Rattus norvegicus	21-41
27262414-0	2016	Relationship between the water-exchangeable fraction of PAH and the organic matter composition of sediments.	Water	25-30	phenylalanine hydroxylase	Homo sapiens	56-59
27262414-3	2016	Simultaneously, the water-exchangeable fraction of the sorbed PAH defined as the amount of PAH freely exchanged between the water and the sediment (by opposition to the PAH harshly sorbed to the sediments particles) was determined using a passive sampler methodology recently developed.	Water	20-25	phenylalanine hydroxylase	Homo sapiens	62-65
27262414-3	2016	Simultaneously, the water-exchangeable fraction of the sorbed PAH defined as the amount of PAH freely exchanged between the water and the sediment (by opposition to the PAH harshly sorbed to the sediments particles) was determined using a passive sampler methodology recently developed.	Water	20-25	phenylalanine hydroxylase	Homo sapiens	91-94
27262414-3	2016	Simultaneously, the water-exchangeable fraction of the sorbed PAH defined as the amount of PAH freely exchanged between the water and the sediment (by opposition to the PAH harshly sorbed to the sediments particles) was determined using a passive sampler methodology recently developed.	Water	20-25	phenylalanine hydroxylase	Homo sapiens	91-94
27262414-3	2016	Simultaneously, the water-exchangeable fraction of the sorbed PAH defined as the amount of PAH freely exchanged between the water and the sediment (by opposition to the PAH harshly sorbed to the sediments particles) was determined using a passive sampler methodology recently developed.	Water	124-129	phenylalanine hydroxylase	Homo sapiens	62-65
27262414-3	2016	Simultaneously, the water-exchangeable fraction of the sorbed PAH defined as the amount of PAH freely exchanged between the water and the sediment (by opposition to the PAH harshly sorbed to the sediments particles) was determined using a passive sampler methodology recently developed.	Water	124-129	phenylalanine hydroxylase	Homo sapiens	91-94
27262414-3	2016	Simultaneously, the water-exchangeable fraction of the sorbed PAH defined as the amount of PAH freely exchanged between the water and the sediment (by opposition to the PAH harshly sorbed to the sediments particles) was determined using a passive sampler methodology recently developed.	Water	124-129	phenylalanine hydroxylase	Homo sapiens	91-94
27262414-5	2016	Hence, the present study provides the distribution coefficients of PAH between the water and 4 different OM fractions combusted at a specific temperature range.	Water	83-88	phenylalanine hydroxylase	Homo sapiens	67-70
27720708-3	2016	To examine the role of NKT cells in the development of uveitis, EAU was elicited by immunization with a peptide from the human interphotoreceptor retinoid-binding protein (hIRBP1-20) in complete Freund"s adjuvant and histopathology scores were evaluated in C57BL/6 (WT) and NKT cell-deficient mice.	Water	64-67	retinol binding protein 3	Homo sapiens	127-170
26965951-4	2016	Results indicate an increased expression of AVP mRNA as well as peptide in the hypothalamus of WD2 mice and the expression was further upregulated after 4days of water deprivation but the expression of CRH remained unchanged compare to their respective controls.	Water	162-167	arginine vasopressin	Mus musculus	44-47
27916848-0	2016	Water Will Be the Coal of the Future-The Untamed Dream of Jules Verne for a Solar Fuel.	Water	0-5	potassium voltage-gated channel interacting protein 3	Homo sapiens	49-54
27561482-6	2016	Furthermore, TGase resulted in an improvement in the water vapor barrier properties and mechanical properties of WPC-CMC (75:25 and 50:50, v/v) composite films, and there was no impairment of thermal stability of composite films.	Water	53-58	transglutaminase 1	Homo sapiens	13-18
27853241-4	2016	Supplementing drinking water with D-serine (600 mg/L from P28 to P56) prevented the onset of cognitive deficits in adult offspring after MIA, in a significant manner.	Water	23-28	cyclin dependent kinase like 2	Homo sapiens	65-68
27854243-5	2016	In this study, combining extensive all-atom molecular dynamics (MD) and replica exchange molecular dynamics (REMD) simulations in explicit water, we shed some light on the differences between the amidated and non-amidated hIAPP conformational ensembles.	Water	139-144	islet amyloid polypeptide	Homo sapiens	222-227
27605664-0	2016	The Mg2+-containing Water Cluster of Mammalian Cytochrome c Oxidase Collects Four Pumping Proton Equivalents in Each Catalytic Cycle.	Water	20-25	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	47-67
27605664-1	2016	Bovine heart cytochrome c oxidase (CcO) pumps four proton equivalents per catalytic cycle through the H-pathway, a proton-conducting pathway, which includes a hydrogen bond network and a water channel operating in tandem.	Water	187-192	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	13-33
27605664-1	2016	Bovine heart cytochrome c oxidase (CcO) pumps four proton equivalents per catalytic cycle through the H-pathway, a proton-conducting pathway, which includes a hydrogen bond network and a water channel operating in tandem.	Water	187-192	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	35-38
27605664-5	2016	The present x-ray structures of oxidized/reduced bovine CcO are improved from 1.8/1.9 to 1.5/1.6 A resolution, increasing the structural information by 1.7/1.6 times and revealing that a large water cluster, which includes a Mg2+ ion, is linked to the H-pathway.	Water	193-198	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	56-59
27605664-7	2016	The redox-coupled x-ray structural changes in Glu198, which bridges the Mg2+ and CuA (the initial electron acceptor from cytochrome c) sites, suggest that the CuA-Glu198-Mg2+ system drives redox-coupled transfer of protons pooled in the water cluster to the H-pathway.	Water	237-242	LOC104968582	Bos taurus	121-133
27605664-8	2016	Thus, these x-ray structures indicate that the Mg2+-containing water cluster is the crucial structural element providing the effective proton pumping in bovine CcO.	Water	63-68	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	160-163
27774543-1	2016	Taking a natural triterpenoid as the building block, we have regulated a pyridinium-functionalized methyl glycyrrhetate (C4-MGP) into P-type helices in water primarily driven by hydrophobic forces.	Water	152-157	matrix Gla protein	Homo sapiens	124-127
27722457-2	2016	At neutral pH the in situ generated aqueous K[H2VVO4] reacts with ligands I and II, forming potassium salts, K(H2O)2[VVO2(bp-bhz)] 5 and K(H2O)2[VVO2(bp-fah)] 6, while ligands III and IV give neutral complexes, [VVO2(Hbp-nah)] 9 and [VVO2(Hbp-inh)] 10, respectively.	Water	111-114	heme binding protein 1	Homo sapiens	217-220
27722457-2	2016	At neutral pH the in situ generated aqueous K[H2VVO4] reacts with ligands I and II, forming potassium salts, K(H2O)2[VVO2(bp-bhz)] 5 and K(H2O)2[VVO2(bp-fah)] 6, while ligands III and IV give neutral complexes, [VVO2(Hbp-nah)] 9 and [VVO2(Hbp-inh)] 10, respectively.	Water	111-114	heme binding protein 1	Homo sapiens	239-242
27783233-6	2016	Furthermore, the natural bond orbital (NBO) and localized molecular orbital energy decomposition analysis (LMO-EDA) methods enable energy analyses of the interaction between NO and H2O in the complexes 1 ., 1 + , and 1 - .	Water	181-184	ectodysplasin A	Homo sapiens	111-114
27762493-4	2017	Here, we have addressed this limitation through the development of a controlled release system, matrix-metalloproteinase (MMP)-sensitive and arg-gly-asp-ser (RGDS) peptide functionalized poly (ethylene-glycol) (PEG) particles which are synthesized via visible-light-induced water-in-water emulsion polymerization.	Water	274-279	ral guanine nucleotide dissociation stimulator	Homo sapiens	158-162
27762493-4	2017	Here, we have addressed this limitation through the development of a controlled release system, matrix-metalloproteinase (MMP)-sensitive and arg-gly-asp-ser (RGDS) peptide functionalized poly (ethylene-glycol) (PEG) particles which are synthesized via visible-light-induced water-in-water emulsion polymerization.	Water	283-288	ral guanine nucleotide dissociation stimulator	Homo sapiens	158-162
28005355-4	2017	The rate coefficients calculated over the 6 x 10-4 - 400 bar range are smaller at least in a factor of about 60 than the consensus value determined for the main reaction channel HO + HO2   H2O + O2, indicating that the recombination pathway is irrelevant.	Water	189-192	heme oxygenase 2	Homo sapiens	183-186
28001352-6	2017	Moreover, the procedures of both the synthesis of MOF and membranes preparation are environmentally friendly that only water was used as solvent.	Water	119-124	lysine acetyltransferase 8	Homo sapiens	50-53
28045152-0	2017	Water-gas-shift reaction on reduced gold-substituted Ce1-xO2(111) surfaces: the role of Au charge.	Water	0-5	carboxylesterase 1	Homo sapiens	53-56
27986625-3	2017	A water-soluble analog of lobelane, R-N-(1,2-dihydroxypropyl)-2,6-cis-di-(4-methoxyphenethyl)piperidine hydrochloride (GZ-793A), also interacts selectively with VMAT2 to inhibit the effects of methamphetamine, but does not produce behavioral tolerance.	Water	2-7	solute carrier family 18 member A2	Homo sapiens	161-166
28024836-9	2017	CONCLUSIONS: Elevated expression of AQP-1, 2, 4, 6 and 7 under testosterone influence in kidneys could lead to increase H2O reabsorption which eventually lead to increase in blood pressure.	Water	120-123	aquaporin 1	Rattus norvegicus	36-41
27966717-0	2017	Ag2S nanoparticle-decorated MoS2 for enhanced electrocatalytic and photoelectrocatalytic activity in water splitting.	Water	101-106	angiotensin II receptor type 1	Homo sapiens	0-4
27966717-2	2017	The A@M composite was used as a catalyst in water splitting which exhibits higher electrocatalytic and photoelectrocatalytic activity than the respective pure MoS2 and Ag2S counterparts.	Water	44-49	angiotensin II receptor type 1	Homo sapiens	168-172
27789039-0	2017	Quantitative assessment of human exposure to extended spectrum and AmpC beta-lactamases bearing E. coli in lettuce attributable to irrigation water and subsequent horizontal gene transfer.	Water	142-147	beta-lactamase	Escherichia coli	67-71
27443479-10	2017	CONCLUSION: Increased AQP1 and AQP4 levels in the heart tissue may be correlated with the maintenance of water and electrolytes balance, which decreases with aging.	Water	105-110	aquaporin 1	Mus musculus	22-26
27836474-2	2017	In this work, we investigated the chemical transformation of AgCl and Ag2S under simulated sunlight (in water) and incineration (in sludge and simulated municipal solid waste, SMSW).	Water	104-109	angiotensin II receptor type 1	Homo sapiens	70-74
26502830-11	2017	G-CSF reduced water content of the edematous poisoned brains (100 microg/kg) and BBB permeability (100 and 150 microg/kg) (P &lt; 0.05).	Water	14-19	colony stimulating factor 3	Rattus norvegicus	0-5
29459481-8	2018	These data implicate the activities of EPHX2 and EPHX3 in production of the linoleate triols detected as end products of the 12R-LOX pathway in the epidermis and implicate their functioning in formation of the mammalian water permeability barrier.	Water	220-225	epoxide hydrolase 2	Homo sapiens	39-44
28840613-8	2018	CONCLUSION: Errors in expected enhancement occur in DCE breast MRI subtraction images because of differential enhancement of fat and water and incomplete fat signal suppression.	Water	133-138	24-dehydrocholesterol reductase	Homo sapiens	52-55
29534032-0	2018	Laser Induced Damage of Potassium Dihydrogen Phosphate (KDP) Optical Crystal Machined by Water Dissolution Ultra-Precision Polishing Method.	Water	89-94	WNK lysine deficient protein kinase 1	Homo sapiens	56-59
29534032-2	2018	In this study, KDP optical crystals are initially machined with single point diamond turning (SPDT), followed by water dissolution ultra-precision polishing (WDUP) and then tested with 355 nm nanosecond pulsed-lasers.	Water	113-118	WNK lysine deficient protein kinase 1	Homo sapiens	15-18
29513647-1	2018	A major source of uncertainty in proton therapy is the conversion of Hounsfield unit (HU) to proton stopping power ratio relative to water (SPR).	Water	133-138	sepiapterin reductase	Homo sapiens	140-143
29225316-5	2017	Analysis by micro-computerized tomography showed that MBP significantly increased tibia cortical bone mineral density and femur trabecular bone volume to tissue volume compared with mice provided deionized water.	Water	206-211	myelin basic protein	Mus musculus	54-57
29282552-10	2018	The water pK a in Mn-SOD is higher than that in Fe-SOD by 3.5 pH units, which is similar to the shift measured experimentally.	Water	4-9	superoxide dismutase 2	Homo sapiens	18-24
27908549-4	2017	RESULTS: The water extracts (dose-dependently for noni leaves) increased bone regeneration biomarker (runt-related transcription factor 2, bone morphogenetic protein 2, osteoprotegerin, estrogen receptor 1 [ESR1], collagen type I alpha 1A) expressions and reduced the inflammatory biomarkers (interleukin-6, tumor necrosis factor-alpha, nuclear factor [NF]-kappaB, and receptor activator of NF-kappaB ligand) mRNA expressions/levels in the rats.	Water	13-18	bone morphogenetic protein 2	Rattus norvegicus	139-167
29282552-10	2018	The water pK a in Mn-SOD is higher than that in Fe-SOD by 3.5 pH units, which is similar to the shift measured experimentally.	Water	4-9	superoxide dismutase 2	Homo sapiens	21-24
28606565-4	2017	METHODS: MBP was chronically administered to mice in their drinking water for 3 wk, and body weight, water intake, and bone mineral density were measured.	Water	68-73	myelin basic protein	Mus musculus	9-12
29147935-5	2018	We examined the coding region of PRNP to determine the nucleotide and octapeptide-repeat (octarepeats) variations of Anatolian, Murrah and Murrah x Anatolian (M x A) water buffaloes.	Water	166-171	major prion protein	Bubalus bubalis	33-37
28606565-4	2017	METHODS: MBP was chronically administered to mice in their drinking water for 3 wk, and body weight, water intake, and bone mineral density were measured.	Water	101-106	myelin basic protein	Mus musculus	9-12
29681968-5	2018	By screening over 500 types of herbal extracts, the water extract of Ginkgo Folium, the leaf of Ginkgo biloba, showed a strong binding to NGF.	Water	52-57	nerve growth factor	Rattus norvegicus	138-141
27924355-5	2017	Antidiuretic hormone (AVP) is known to increase active NaCl transport to support collecting duct water reabsorption.	Water	97-102	arginine vasopressin	Mus musculus	22-25
27997616-2	2016	In this study, a water soluble polysaccharide, which we designated as UP2, with an average molecular weight of 3.33 x 105 Da, was isolated from U. esculenta cultivated in the Huangshan Mountain, by consecutive hot water extraction and anion-exchange chromatography.	Water	17-22	uroplakin 2	Mus musculus	70-73
29411808-1	2018	An Al(iii) metal-organic framework (MOF) called Al-MIL-53-N3 (1) was synthesized under solvothermal reaction conditions using Al(NO3)3 9H2O and H2BDC-N3 (H2BDC-N3 = 2-azido-1,4-benzenedicarboxylic acid) ligand in a DMF/water (DMF = N,N-dimethylformamide) mixture.	Water	219-224	lysine acetyltransferase 8	Homo sapiens	11-40
27619383-0	2016	About the nanostructure of the ternary system water - [BMIm]PF6 - TX-100.	Water	46-51	sperm associated antigen 17	Homo sapiens	60-63
29411808-7	2018	The detection limits (90.47 nM for H2S and 0.03 muM for Fe(iii) ions in water) of 1" are lower than those of the formerly reported MOF type of fluorescent sensors.	Water	72-77	lysine acetyltransferase 8	Homo sapiens	131-134
27934386-1	2016	An unprecedented hydration/transfer hydrogenation tandem process for the catalytic conversion of beta-ketonitriles into synthetically useful beta-hydroxyamides in water has been developed, making use of the ruthenium(II) complex [RuCl2(eta6-p-cymene){P(4-C6H4F)2Cl}] in combination with sodium formate.	Water	163-168	endothelin receptor type A	Homo sapiens	98-101
28958545-1	2018	The objective of this work was to study solid/oil/water (S/O/W) emulsions as delivery systems with retained lactase in milk and controlled release during in vitro digestion.	Water	50-55	lactase	Homo sapiens	108-115
26927538-8	2016	RESULTS: After one cycle, SnF2 resulted in least step height followed by NaF and water (1.3 mum (0.63), 2.3 mum (0.39), 4.3 mum (0.41) respectively; P &lt; 0.0001).	Water	81-86	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	26-30
29350908-0	2018	Light Modulation and Water Splitting Enhancement Using a Composite Porous GaN Structure.	Water	21-26	gigaxonin	Homo sapiens	74-77
26845478-4	2016	The water-solubility of SV increased linearly upon the addition of both HP-beta-CD and RM-beta-CD, due to the formation of inclusion complexes.	Water	4-9	beta-carotene oxygenase 1	Mus musculus	75-82
29350908-2	2018	Compared to the plane GaN, the composite porous GaN structure with the combination of the vertical holes can help to reduce UV reflectance and increase the saturation photocurrent during water splitting by a factor of ~4.5.	Water	187-192	gigaxonin	Homo sapiens	48-51
26845478-4	2016	The water-solubility of SV increased linearly upon the addition of both HP-beta-CD and RM-beta-CD, due to the formation of inclusion complexes.	Water	4-9	beta-carotene oxygenase 1	Mus musculus	90-97
29427239-2	2018	METHODS: PLG nanoparticles were prepared by a double emulsion (water-in-oil-in-water; W/O/W) method.	Water	63-68	plasminogen	Mus musculus	9-12
26845478-8	2016	Accordingly, it is concluded that the inclusion complexation of SV with RM-beta-CD is a potential formulation for bone regenerative therapy to improve water-solubility and osteodifferentiation efficiency.	Water	151-156	beta-carotene oxygenase 1	Mus musculus	75-82
27538264-0	2016	The c.-360 T&gt;C mutation affects PGAM2 transcription activity and is linked with the water holding capacity of the longissimus lumborum muscle in pigs.	Water	87-92	phosphoglycerate mutase 2	Sus scrofa	35-40
29427239-2	2018	METHODS: PLG nanoparticles were prepared by a double emulsion (water-in-oil-in-water; W/O/W) method.	Water	79-84	plasminogen	Mus musculus	9-12
27538264-2	2016	This study examined a functional mutation in the PGAM2 gene and evaluated its relationship with water holding capacity (WHC).	Water	96-101	phosphoglycerate mutase 2	Sus scrofa	49-54
27308947-3	2016	In water containing air gas close to the saturation concentration (within ~40%), cap-shaped nanostructures (or interfacial nanobubbles) and ordered-stripe domains were observed on graphene-covered regions but not on pure mica regions.	Water	3-8	MHC class I polypeptide-related sequence A	Homo sapiens	221-225
29139396-1	2018	In this study, an oil-soluble Ag2S quantum dot (QD) was synthesized through thermal decomposition using the single-source precursor method, and Pluronic F127 (PF127), a triblock copolymer functionalized with folic acid (FA), was deposited on the surface of the QD, then a water-soluble PF127-FA@Ag2S nanoprobe with targeting ability was fabricated.	Water	272-277	angiotensin II receptor type 1	Homo sapiens	30-34
27577115-6	2016	Leaves of the myb94 myb96 mutant lost water through the cuticle faster than those of myb94 or myb96 plants.	Water	38-43	myb domain protein 96	Arabidopsis thaliana	20-25
27723961-5	2016	The visible light (lambda &gt; 400 nm) driven photocatalytic properties of CNF@SnS2 are evaluated by the reduction of water-soluble Cr(VI).	Water	118-123	sodium voltage-gated channel alpha subunit 11	Homo sapiens	79-83
27474578-3	2016	Four water-soluble polysaccharides named as BP1-1, BP1-2, BP1-3 and BP1-4, with molecular weight of 35.8, 32.4, 30.1 and 27.7kDa, were purified by DEAE Sepharose and Superdex 200 chromatography.	Water	5-10	BP11	Homo sapiens	44-49
27474578-3	2016	Four water-soluble polysaccharides named as BP1-1, BP1-2, BP1-3 and BP1-4, with molecular weight of 35.8, 32.4, 30.1 and 27.7kDa, were purified by DEAE Sepharose and Superdex 200 chromatography.	Water	5-10	BP13	Homo sapiens	58-63
27659807-8	2016	The film structure at the air-water interface could differentiate the SPC- and HSPC-comprising systems through the formation of organized regions, especially at a higher surface pressure.	Water	30-35	proteasome 20S subunit alpha 7	Homo sapiens	79-83
27653243-6	2016	Stabilizing hydrogen bonds (H-bonds) formed by the hydroxyl substituent in 5hmC or from a bridging water in the 5mC structure provide approximately 1.5-2 kcal/mol per interaction of stability to the junction, which is mostly offset by entropy compensation, thereby leaving the overall stability of the G5hmCC and G5mCC constructs similar to that of the GCC core.	Water	99-104	guanylate cyclase 2C	Homo sapiens	353-356
28138374-9	2016	RESULTS: Twenty-seven (45%) out of 60 water samples were positive to Acanthamoeba spp.	Water	38-43	histocompatibility minor 13	Homo sapiens	82-85
27465993-0	2016	The EP3 receptor regulates water excretion in response to high salt intake.	Water	27-32	prostaglandin E receptor 3	Rattus norvegicus	4-7
27129881-1	2016	Four Astragalus polysaccharides (APS1-APS4) were isolated from the water extract of Radix Astragali and purified through ethanol precipitation with 20 %, 40 %, 60 % and 80 % ethanol, respectively.	Water	67-72	nudix hydrolase 11	Homo sapiens	33-37
24130076-7	2016	The optimal water content of the hydrogel and bFGF dose was determined as 96% and 30 microg per sheet, respectively.	Water	12-17	fibroblast growth factor 2	Rattus norvegicus	46-50
27782721-14	2016	When adding noise to the theoretical CT numbers the SPR parametrization gave the lowest water equivalent range errors of all four tested SPR estimation methods (maximum error reduced to 0.4 mm).	Water	88-93	sepiapterin reductase	Homo sapiens	52-55
27618652-6	2016	Ex vivo culture of human adult peripheral T cells with sterile fecal water from NGM3 subjects increased the proportion of CD4+ cells producing interleukin (IL)-4 and reduced the relative abundance of CD4+CD25+FOXP3+ cells.	Water	69-74	forkhead box P3	Homo sapiens	209-214
27618652-7	2016	12,13-DiHOME, enriched in NGM3 versus lower-risk NGM states, recapitulated the effect of NGM3 fecal water on relative CD4+CD25+FOXP3+ cell abundance.	Water	100-105	forkhead box P3	Homo sapiens	127-132
27598838-1	2016	In this work, we report the synthesis of Cd1-xZnxS zinc blende/wurtzite (ZB/WZ) heterophase nanojunctions with highly efficient charge separation by a solvothermal method in a mixed solution of diethylenetriamine (DETA) and distilled water.	Water	234-239	CD1c molecule	Homo sapiens	41-44
27649492-0	2016	Upper Limb Evaluation in Duchenne Muscular Dystrophy: Fat-Water Quantification by MRI, Muscle Force and Function Define Endpoints for Clinical Trials.	Water	58-63	FAT atypical cadherin 1	Homo sapiens	54-57
27649492-6	2016	3-Tesla MRI fat-water quantification was used to measure forearm muscle fat transformation in non-ambulant DMD boys compared with healthy controls.	Water	16-21	FAT atypical cadherin 1	Homo sapiens	12-15
27484443-2	2016	The reaction of CuCl2, HL 2HCl and triethylamine (NEt3) in a molar ratio of 1 : 1 : 3 in water was found to generate a novel organometallic tetrazole derivative Cu2L2Cl2.	Water	89-94	tetraspanin 2	Homo sapiens	50-54
27532805-9	2016	The present investigation reveals that CdS nanosheets together with SPR Au NPs improve the photoelectrochemical water splitting activity and stability of LaBTC MOFs.	Water	112-117	sepiapterin reductase	Homo sapiens	68-71
27529544-1	2016	A robust and water-stable metal-organic framework (MOF), featuring hexagonal channels decorated with methionine residues (1), selectively captures toxic species such as CH3 Hg(+) and Hg(2+) from water.	Water	195-200	lysine acetyltransferase 8	Homo sapiens	26-55
27529544-2	2016	1 exhibits the largest Hg(2+) uptake capacity ever reported for a MOF, decreasing the [Hg(2+) ] and [CH3 Hg(+) ] concentrations in potable water from highly hazardous 10 ppm to the much safer values of 6 and 27 ppb, respectively.	Water	139-144	lysine acetyltransferase 8	Homo sapiens	66-69
28217276-2	2016	The discovery that a water-soluble phosphate prodrug salt of CA4 (referred to as CA4P) is capable of imparting profound and selective damage to tumor-associated blood vessels paved the way for the development of a new therapeutic approach for cancer treatment utilizing small-molecule inhibitors of tubulin polymerization that also act as vascular disrupting agents (VDAs).	Water	21-26	carbonic anhydrase 4	Mus musculus	61-64
28217276-2	2016	The discovery that a water-soluble phosphate prodrug salt of CA4 (referred to as CA4P) is capable of imparting profound and selective damage to tumor-associated blood vessels paved the way for the development of a new therapeutic approach for cancer treatment utilizing small-molecule inhibitors of tubulin polymerization that also act as vascular disrupting agents (VDAs).	Water	21-26	carbonic anhydrase 4	Mus musculus	81-85
28078254-0	2016	Achyranthes japonica Nakai Water Extract Suppresses Binding of IgE Antibody to Cell Surface FceRI.	Water	27-32	Fc epsilon receptor Ia	Homo sapiens	92-97
27788576-4	2016	The high selectivity and easy separation of the as-prepared material have shown tremendous potential for practical applications in the nuclear industry or radioactive water treatment, and the functionalized MOF can be extended readily upon the versatility of click chemistry.	Water	167-172	lysine acetyltransferase 8	Homo sapiens	207-210
27809469-0	2016	Superacidity in Nafion/MOF Hybrid Membranes Retains Water at Low Humidity to Enhance Proton Conduction for Fuel Cells.	Water	52-57	lysine acetyltransferase 8	Homo sapiens	23-26
27728765-3	2016	Sequentially, the functionalization of PorMOF with streptavidin results in a water-stable electrochemical tracer for detection of telomerase.	Water	77-82	lysine acetyltransferase 8	Homo sapiens	39-45
27632703-4	2016	In the present study, we demonstrated that a water-soluble bis-malonic acid fullerene derivative (C60-dicyclopropane-1,1,1",1"-tetracarboxylic acid) markedly diminished the IL-33-induced expression of IL-6 in bone marrow-derived mast cells (BMMC).	Water	45-50	interleukin 33	Homo sapiens	173-178
27711732-2	2016	However, to meet the demands of large-scale water treatment, a SnS2 photocatalyst with a red-shifted band gap, increased surface area and accelerated molecule and ion diffusion is required.	Water	44-49	sodium voltage-gated channel alpha subunit 11	Homo sapiens	63-67
27607355-0	2016	Highly Dispersed Polyoxometalate-Doped Porous Co3 O4 Water Oxidation Photocatalysts Derived from POM@MOF Crystalline Materials.	Water	53-58	lysine acetyltransferase 8	Homo sapiens	101-104
27704794-3	2016	In biomimicry and bioremediation, an important reaction relates to the detoxification of ClOx- in water, which can lead to a mixture of products through bifurcated reactions.	Water	98-103	cut like homeobox 1	Homo sapiens	89-93
27828080-0	2016	Effects of temperature on the removal efficiency of KDP crystal during the process of magnetorheological water-dissolution polishing.	Water	105-110	WNK lysine deficient protein kinase 1	Homo sapiens	52-55
27828080-2	2016	Based on the dissolution mechanism of solid materials, the factors that affect the material removal rate of KDP crystal in magnetorheological (MR) water-dissolution polishing are investigated to improve the machining efficiency.	Water	147-152	WNK lysine deficient protein kinase 1	Homo sapiens	108-111
27647193-14	2016	CONCLUSIONS: Hydrogen-rich water may improve serum AMH levels and reduce ovarian GC apoptosis in a mouse immune POF model induced by ZP3.	Water	27-32	anti-Mullerian hormone	Mus musculus	51-54
27625114-3	2016	The other reaction product, water, is removed in situ through a hydrophilic Na-LTA layer, which is located between the porous alumina support and the H-FAU top layer.	Water	28-33	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	152-155
27541982-4	2016	As compared to its precursor, [C12mpip][AcSa] has low CAC values, indicating enhanced favorable interactions between the [alkylmpip]+ cation   bulky [AcSa]- anion and also hydrogen bonding of both of the ions with water.	Water	214-219	acyl-CoA synthetase short chain family member 2	Homo sapiens	40-44
27109486-4	2016	This work re-analyzed data from a recent study in healthy controls and patients with minimal (mHE) or grade I (HE 1) hepatic encephalopathy, a disease associated with slight elevation of brain water content.	Water	193-198	NPC intracellular cholesterol transporter 2	Homo sapiens	111-115
26992959-4	2016	Evidence based on the sweet water aftertastes of several novel sweetness inhibitors is presented providing new support for constitutive activity in T1R2/T1R3.	Water	28-33	taste 1 receptor member 3	Homo sapiens	153-157
27593465-8	2016	Furthermore, AtABCG25 overexpression enhanced drought tolerance, probably resulting from maintenance of water contents over the common threshold for survival after drought stress treatment.	Water	104-109	ATP-binding casette family G25	Arabidopsis thaliana	13-21
27593465-9	2016	Finally, we observed enhanced water use efficiency by overexpression of AtABCG25, in addition to drought tolerance.	Water	30-35	ATP-binding casette family G25	Arabidopsis thaliana	72-80
27680940-3	2016	Here we show that the sleep period in mice (Zeitgeber time, ZT0-12) is preceded by an increase in water intake promoted entirely by the central clock, and not motivated by physiological need.	Water	98-103	zinc finger protein 125	Mus musculus	60-66
27653548-7	2016	Furthermore, urinary NGAL levels were greater in water-restricted than control SHR.	Water	49-54	lipocalin 2	Rattus norvegicus	21-25
27524311-0	2016	Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2.	Water	37-42	solute carrier family 18 member A2	Homo sapiens	112-145
27599590-0	2016	Anti-inflammatory effects of Sanguisorbae Radix water extract on the suppression of mast cell degranulation and STAT-1/Jak-2 activation in BMMCs and HaCaT keratinocytes.	Water	48-53	Janus kinase 2	Homo sapiens	119-124
27486675-3	2016	The interaction of the IL ions of [Rmim][NTf2] with water molecules through hydrogen bonding is suspected to disrupt IL ion layering and precursor film growth on mica.	Water	52-57	MHC class I polypeptide-related sequence A	Homo sapiens	162-166
27529544-1	2016	A robust and water-stable metal-organic framework (MOF), featuring hexagonal channels decorated with methionine residues (1), selectively captures toxic species such as CH3 Hg(+) and Hg(2+) from water.	Water	13-18	lysine acetyltransferase 8	Homo sapiens	26-55
27391840-0	2016	Direct Synthesis of Water-Soluble Aptamer-Ag2 S Quantum Dots at Ambient Temperature for Specific Imaging and Photothermal Therapy of Cancer.	Water	20-25	angiotensin II receptor type 1	Homo sapiens	42-47
27391840-1	2016	Water-soluble Ag2 S near-infrared (NIR) fluorescent quantum dots (QDs) are directly synthesized at ambient temperature for specific cancer imaging and photothermal therapy (PTT) using a designed aptamer (Apt43) as template, which consists of the following two fragments: an aptamer S2.2 sequence for specifically recognizing the cancer cells and an 18-cytosine (18-C) extending spacer for growing Ag2 S QDs.	Water	0-5	angiotensin II receptor type 1	Homo sapiens	14-19
27391840-1	2016	Water-soluble Ag2 S near-infrared (NIR) fluorescent quantum dots (QDs) are directly synthesized at ambient temperature for specific cancer imaging and photothermal therapy (PTT) using a designed aptamer (Apt43) as template, which consists of the following two fragments: an aptamer S2.2 sequence for specifically recognizing the cancer cells and an 18-cytosine (18-C) extending spacer for growing Ag2 S QDs.	Water	0-5	angiotensin II receptor type 1	Homo sapiens	397-402
29393883-9	2018	Likewise, it was observed that for higher proportions of carboxylate groups in the polymeric structure, the capability to retain water is increased and, only can be eliminated by drying at temperatures greater than 160  C. On the other hand, the modification of PAM-18 to its ionized forms led to the formation of powder materials with low flowability and surfaces that ranged from very hydrophobic to slightly wettable.	Water	129-134	DnaJ heat shock protein family (Hsp40) member C19	Homo sapiens	262-268
27239970-3	2016	The results show that F(-) ions in shallow groundwater at the study area come mainly from the dissolution of fluorinated minerals in a form of fluorite (CaF2), the so-called water-rock interaction, and there is a higher possibility for the occurrence of fluorine water where the ratio of (K(+) + Na(+))/Ca(2+) exceeds a value of 2.1.	Water	49-54	CCR4-NOT transcription complex subunit 8	Homo sapiens	153-157
27239970-3	2016	The results show that F(-) ions in shallow groundwater at the study area come mainly from the dissolution of fluorinated minerals in a form of fluorite (CaF2), the so-called water-rock interaction, and there is a higher possibility for the occurrence of fluorine water where the ratio of (K(+) + Na(+))/Ca(2+) exceeds a value of 2.1.	Water	174-179	CCR4-NOT transcription complex subunit 8	Homo sapiens	153-157
29408790-1	2018	A new reconstruction method, coined MIRAGE, is presented for accurate, fast, and robust parameter mapping of multiple-echo gradient-echo (MEGE) imaging, the basis sequence of novel quantitative magnetic resonance imaging techniques such as water content and susceptibility mapping.	Water	240-245	sterile alpha motif domain containing 9	Homo sapiens	36-42
27255319-3	2016	The activity of TiO2-FeZ, immobilized on glass support, was evaluated under solar irradiation for removal of diclofenac (DCF) in water.	Water	129-134	FEZ family zinc finger 1	Homo sapiens	21-24
27255324-5	2016	Symmetric and dissymmetric Gemini surfactants have opposite effect on the aspect of removing of PAH attributing to their solubilization and sorption behavior in soil-water system.	Water	166-171	phenylalanine hydroxylase	Homo sapiens	96-99
27658468-2	2016	By combining prior information from dynamic contrast enhanced (DCE) and diffusion weighted (DW) MR images, the absolute bias errors of HbT and water in the tumor were reduced by 22% and 18%, 21% and 6%, and 10% and 11%, compared to that in the no-prior, DCE- or DW-guided reconstructed images in three-dimensional simulations, respectively.	Water	143-148	24-dehydrocholesterol reductase	Homo sapiens	63-66
27658468-2	2016	By combining prior information from dynamic contrast enhanced (DCE) and diffusion weighted (DW) MR images, the absolute bias errors of HbT and water in the tumor were reduced by 22% and 18%, 21% and 6%, and 10% and 11%, compared to that in the no-prior, DCE- or DW-guided reconstructed images in three-dimensional simulations, respectively.	Water	143-148	24-dehydrocholesterol reductase	Homo sapiens	254-257
27658468-3	2016	In addition, the apparent contrast values of HbT and water were increased in patient image reconstruction from 1.4 and 1.4 (DCE) or 1.8 and 1.4 (DW) to 4.6 and 1.6.	Water	53-58	24-dehydrocholesterol reductase	Homo sapiens	124-127
27558862-3	2016	Both type I and type III NRG1 improves deficits in the Morris water-maze behavioral task.	Water	62-67	neuregulin 1	Mus musculus	25-29
27560924-6	2016	The sum of water-soluble metabolites per total protein was 17% higher in ABCB5-WT vs. ABCB5-KD G3361 variants, but no difference was found for the sum of PLs.	Water	11-16	ATP binding cassette subfamily B member 5	Homo sapiens	73-78
27560924-6	2016	The sum of water-soluble metabolites per total protein was 17% higher in ABCB5-WT vs. ABCB5-KD G3361 variants, but no difference was found for the sum of PLs.	Water	11-16	ATP binding cassette subfamily B member 5	Homo sapiens	86-91
27242198-3	2016	Both two H-shape GLCL molecules could individually self-assemble into cationic nanoparticles in water phase and complex with negatively-charged siRNA into nanoplexes with particle size of ~200nm and zeta potential of ~ +30mV, and exhibit effective siRNA delivery both in vitro and in vivo.	Water	96-101	glutamate-cysteine ligase catalytic subunit	Homo sapiens	17-21
27460349-0	2016	A Cu(ii) MOF with a flexible bifunctionalised terpyridine as an efficient catalyst for the single-pot hydrocarboxylation of cyclohexane to carboxylic acid in water/ionic liquid medium.	Water	158-163	lysine acetyltransferase 8	Homo sapiens	9-12
27508436-3	2016	However, previous studies have shown that SP-A also aids in the formation and biophysical properties of pulmonary surfactant films at the air-water interface.	Water	142-147	surfactant protein A1	Homo sapiens	42-46
27493996-3	2016	This particular MOF can be used as a reservoir for storage of cargo in water, and the cargo-loaded MOF can be further capped to construct a mechanized MOF through the binding of beta-cyclodextrin with the azobenzene stalks on the MOF surface.	Water	71-76	lysine acetyltransferase 8	Homo sapiens	16-19
27493996-3	2016	This particular MOF can be used as a reservoir for storage of cargo in water, and the cargo-loaded MOF can be further capped to construct a mechanized MOF through the binding of beta-cyclodextrin with the azobenzene stalks on the MOF surface.	Water	71-76	lysine acetyltransferase 8	Homo sapiens	99-102
27493996-3	2016	This particular MOF can be used as a reservoir for storage of cargo in water, and the cargo-loaded MOF can be further capped to construct a mechanized MOF through the binding of beta-cyclodextrin with the azobenzene stalks on the MOF surface.	Water	71-76	lysine acetyltransferase 8	Homo sapiens	99-102
27493996-3	2016	This particular MOF can be used as a reservoir for storage of cargo in water, and the cargo-loaded MOF can be further capped to construct a mechanized MOF through the binding of beta-cyclodextrin with the azobenzene stalks on the MOF surface.	Water	71-76	lysine acetyltransferase 8	Homo sapiens	99-102
27252474-0	2016	Nax signaling evoked by an increase in [Na+] in CSF induces water intake via EET-mediated TRPV4 activation.	Water	60-65	sodium channel, voltage-gated, type VII, alpha	Mus musculus	0-3
27252474-3	2016	We herein investigated voluntary water intake immediately induced after an intracerebroventricular administration of a hypertonic NaCl solution in TRPV1-, TRPV4-, Nax-, and their double-gene knockout (KO) mice.	Water	33-38	sodium channel, voltage-gated, type VII, alpha	Mus musculus	163-166
27108109-7	2016	The immobilized PLA1 was more active when water addition was above 0.5 wt %.	Water	42-47	lipase H	Homo sapiens	16-20
27490440-5	2016	The resulting electrode, i.e., [Ce(III)(DMF) (HSO4)3]-l-cysteine-Au stacks shows high electrocatalytic water oxidation behavior at an overpotential of eta   0.34 V under neutral pH conditions.	Water	103-108	endothelin receptor type A	Homo sapiens	151-154
27601896-2	2016	To synergistically and completely reverse MDR by simultaneous inhibition of pump and non-pump cellular resistance, three-in-one multifunctional lipid-sodium glycocholate (GcNa) nanocarriers (TMLGNs) have been designed for controlled co-delivery of water-soluble cationic mitoxantrone hydrochloride (MTO), cyclosporine A (CsA - BCRP inhibitor), and GcNa (Bcl-2 inhibitor).	Water	248-253	germ cell nuclear acidic peptidase	Homo sapiens	171-175
27477824-4	2016	We further show that the water splitting occurs through a surface Ru(VIII) intermediate, and, contrary to common opinion, the presence of Ir does not hinder its formation.	Water	25-30	cytochrome c oxidase subunit 8A	Homo sapiens	69-73
27454810-2	2016	In several cases, even the neutral ligands, in addition to their protonated HL(+) and H2L(2+) (L = L1 and L2) forms, bind anions such as F(-), NO3(-), PF6(-), ClO4(-), and SO4(2-) to form stable complexes in water.	Water	208-213	sperm associated antigen 17	Homo sapiens	151-154
27493996-2	2016	We report the design and synthesis of a water-stable zirconium MOF (Zr-MOF) that bears photoresponsive azobenzene groups.	Water	40-45	lysine acetyltransferase 8	Homo sapiens	63-66
27493996-2	2016	We report the design and synthesis of a water-stable zirconium MOF (Zr-MOF) that bears photoresponsive azobenzene groups.	Water	40-45	lysine acetyltransferase 8	Homo sapiens	71-74
27292613-5	2016	The amphiphilic macromolecules (termed TAT-PEG-Asp8-Dox) could self-assemble into nanoparticles (NPs) in water.	Water	105-110	tyrosine aminotransferase	Homo sapiens	39-42
27358027-3	2016	The haemodynamic and non-haemodynamic effects of Ang II, including its ability to regulate blood pressure, maintain water-electrolyte balance and promote vasoconstriction and cellular growth are well-documented to be mediated primarily by the AT1R.	Water	116-121	angiotensin II receptor type 1	Homo sapiens	243-247
27179807-5	2016	After ischemia-reperfusion injury, we found that HSPA12B overexpression decreased spinal cord water content and infarct volume.	Water	94-99	heat shock protein family A (Hsp70) member 12B	Homo sapiens	49-56
27469628-0	2016	Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis.	Water	87-92	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	30-34
28401489-6	2018	In addition, the expression of CXCR3 and CXCL10 was increased in the spinal cord in the dry skin model induced by acetone and diethyl ether followed by water (AEW).	Water	152-157	chemokine (C-X-C motif) ligand 10	Mus musculus	41-47
27181510-1	2016	Aquaporin-1 (AQP1) is a water channel expressed in the choroid plexus and participates in forming cerebrospinal fluid.	Water	24-29	aquaporin 1	Rattus norvegicus	0-11
27181510-1	2016	Aquaporin-1 (AQP1) is a water channel expressed in the choroid plexus and participates in forming cerebrospinal fluid.	Water	24-29	aquaporin 1	Rattus norvegicus	13-17
29322157-2	2018	X-ray structure analyses of both the anhydrous 1P and penta-hydrated 1P 5H2O phases clearly reveal the activation of intermolecular PtPt interactions through the adsorption of water vapour.	Water	176-181	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	132-136
27181510-10	2016	AQP1 upregulation/AQP4 downregulation induced under subtoxic 3NP treatment may play a pivotal role in water homeostasis and cell viability in the striatum.	Water	102-107	aquaporin 1	Rattus norvegicus	0-4
29215207-4	2018	As a result, the Pt@MOF/Au presents an exceptionally high photocatalytic H2 production rate by water splitting under visible light irradiation, far superior to Pt/MOF/Au, MOF/Au and other counterparts with similar Pt or Au contents, highlighting the important role of each component and the Pt location in the catalyst.	Water	95-100	lysine acetyltransferase 8	Homo sapiens	20-23
27337245-1	2016	The effect of confinement between mica and graphene on the structure and dynamics of alcohol-water mixtures has been studied in situ and in real time at the molecular level by atomic force microscopy (AFM) at room temperature.	Water	93-98	MHC class I polypeptide-related sequence A	Homo sapiens	34-38
27452615-0	2016	The Effect of Water and Confinement on Self-Assembly of Imidazolium Based Ionic Liquids at Mica Interfaces.	Water	14-19	MHC class I polypeptide-related sequence A	Homo sapiens	91-95
29182696-1	2018	The effect of the functional ionic group of 4,4"-bipyridinium salt derivatives (4,4"-BPs) as the electron carrier on the visible-light driven conversion of CO2 to formic acid with the system consisting of water-soluble zinc tetraphenylporphyrin tetrasulfonate (ZnTPPS) and formate dehydrogenase (FDH) in the presence of triethanolamine (TEOA) as an electron donor was investigated.	Water	205-210	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	296-299
27452672-8	2016	Adropin levels were inversely correlated with body mass, lean tissue mass, total, intracellular, and extracellular water, and albumin concentrations in patients with ESRD.	Water	115-120	energy homeostasis associated	Homo sapiens	0-7
27455244-2	2016	In our previous study, we found the co-expression of the AQP1 water channel and AQP7 in the mouse WAT.	Water	62-67	aquaporin 1	Mus musculus	57-61
27455244-7	2016	In conclusion, the AQP1 water channel located in the vessels of WAT is up-regulated in response to prolonged starvation in the WAT of AQP7 KO mice.	Water	24-29	aquaporin 1	Mus musculus	19-23
28864207-9	2018	These results suggest that RXFP1 is involved in the RLN3 stimulation of water intake and activation of the HPA and HPG axes.	Water	72-77	relaxin family peptide receptor 1	Rattus norvegicus	27-32
27140531-2	2016	We focus on the first stage of peptide bond cleavage by matrix metalloproteinase-2 (MMP-2), that is, the nucleophilic attack of the zinc-coordinating water molecule on the carbonyl carbon atom of the scissile fragment of the substrate.	Water	150-155	matrix metallopeptidase 2	Homo sapiens	56-82
27140531-2	2016	We focus on the first stage of peptide bond cleavage by matrix metalloproteinase-2 (MMP-2), that is, the nucleophilic attack of the zinc-coordinating water molecule on the carbonyl carbon atom of the scissile fragment of the substrate.	Water	150-155	matrix metallopeptidase 2	Homo sapiens	84-89
29208522-2	2018	Thus, structure-based virtual screening was performed to identify novel scaffolds of GSK-3beta inhibitors, and we observed that conserved water molecules of GSK-3beta were suitable for virtual screening.	Water	138-143	glycogen synthase kinase 3 beta	Homo sapiens	85-94
27140531-6	2016	Since the substrate in MMP-2 is located on the protein surface, we investigate the influence of the thickness of the water layer around the enzyme on the QM/MM energy profile.	Water	117-122	matrix metallopeptidase 2	Homo sapiens	23-28
27185047-0	2016	Interactions of the "piano-stool" [ruthenium(II)(eta(6) -arene)(quinolone)Cl](+) complexes with water; DFT computational study.	Water	96-101	endothelin receptor type A	Homo sapiens	49-52
27405371-10	2016	BiP overexpression also conferred tolerance to water stress in Arabidopsis, most likely due to modulation of the drought-induced NRP-mediated cell death response.	Water	47-52	Heat shock protein 70 (Hsp 70) family protein	Arabidopsis thaliana	0-3
29208522-2	2018	Thus, structure-based virtual screening was performed to identify novel scaffolds of GSK-3beta inhibitors, and we observed that conserved water molecules of GSK-3beta were suitable for virtual screening.	Water	138-143	glycogen synthase kinase 3 beta	Homo sapiens	157-166
29101877-9	2018	Finally, C18-Mica-4 was applied successfully to the removal of the target compounds from influent and effluent wastewater, surface water and tap water samples.	Water	116-121	MHC class I polypeptide-related sequence A	Homo sapiens	13-17
29101877-9	2018	Finally, C18-Mica-4 was applied successfully to the removal of the target compounds from influent and effluent wastewater, surface water and tap water samples.	Water	131-136	MHC class I polypeptide-related sequence A	Homo sapiens	13-17
29066420-9	2018	Ionic releases (Cu+/Cu2+, Ca2+, PO42- and OH-) in water and in simulated body media were investigated on as-synthesized ceramics to establish a pretreatment before biological applications.	Water	50-55	ERC2 intronic transcript 1	Homo sapiens	32-36
27409596-0	2016	Photocatalytic Water Splitting-The Untamed Dream: A Review of Recent Advances.	Water	15-20	potassium voltage-gated channel interacting protein 3	Homo sapiens	43-48
29526897-1	2018	A method capable of accurately and selectively measuring Cr3+ in water is required and was therefore studied.	Water	65-70	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	57-60
27599507-1	2016	The effect of single nucleotide polymorphisms (SNP) of TRPV4 gene on the development of airway hyperresponsiveness (39.7% of cases) in response to the decrease in osmolarity under inspiration of distilled water aerosol was studies in 189 patients with uncontrolled bronchial asthma.	Water	205-210	transient receptor potential cation channel subfamily V member 4	Homo sapiens	55-60
27648015-10	2016	CONCLUSION: Fluid volume imbalance between intra- and extracellular water regulated by decreased cell mass was independently associated with BNP levels, which may explain the reserve capacity for fluid accumulation in patients with CKD.	Water	68-73	natriuretic peptide B	Homo sapiens	141-144
29526897-5	2018	This method should be readily adapted for the routine and selective determination of Cr3+ in bottled mineral drinking water with (or without) the supplementation of Cr3+ or in natural water such as mineral or pipe water with the presence of Cr6+.	Water	118-123	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	85-88
27089053-6	2016	Interestingly, three species of Ceratopogonidae and a cold-water species of Chironomidae exhibited high constitutive levels of Hsp70 mRNA and high basal levels of Hsp70.	Water	59-64	Heat-shock-protein-70Ab	Drosophila melanogaster	127-132
27089422-7	2016	A linear regression method was used to examine the association between water salinity exposure categories and systolic BP (SBP) and diastolic BP (DBP) level.	Water	71-76	selenium binding protein 1	Homo sapiens	110-144
29526897-5	2018	This method should be readily adapted for the routine and selective determination of Cr3+ in bottled mineral drinking water with (or without) the supplementation of Cr3+ or in natural water such as mineral or pipe water with the presence of Cr6+.	Water	184-189	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	85-88
27089422-9	2016	Multivariable linear regression analyses identified that compared to the low water salinity exposure category (&lt;600 mg/L), those in the high water salinity category (&gt;600 mg/L), had statistically significantly higher SBP (B 3.46, 95% CI 0.75, 6.17; p = 0.01) and DBP (B 2.77, 95% CI 0.31, 5.24; p = 0.03).	Water	144-149	selenium binding protein 1	Homo sapiens	223-226
27089053-6	2016	Interestingly, three species of Ceratopogonidae and a cold-water species of Chironomidae exhibited high constitutive levels of Hsp70 mRNA and high basal levels of Hsp70.	Water	59-64	Heat-shock-protein-70Ab	Drosophila melanogaster	163-168
29526897-5	2018	This method should be readily adapted for the routine and selective determination of Cr3+ in bottled mineral drinking water with (or without) the supplementation of Cr3+ or in natural water such as mineral or pipe water with the presence of Cr6+.	Water	184-189	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	85-88
29170024-3	2018	BET BD1 and BD2 bromodomains differ at five positions near the substrate binding pocket: the variation in the ZA channel induces different water networks nearby.	Water	139-144	delta/notch like EGF repeat containing	Homo sapiens	0-3
27260501-1	2016	The presence of Aquaporins 1 (AQP1) and 9 (AQP9), integral membrane water channels that facilitate rapid passive movement of water and solutes, was immunohistochemically detected in the excurrent ducts collected from sexually mature buffalo bulls of proven fertility during the mating (late autumn-winter) and non-mating (late spring to the beginning of autumn) seasons.	Water	68-73	aquaporin-9	Bubalus bubalis	43-47
28631388-7	2018	RESULTS: There was no significant difference in cell viability amongst HBSS, SAT and EMT groups up to 6 h. SAT was effective in maintaining cell viability only up to 12 h and then became detrimental to HPDLF; after 24 h, the effectiveness of SAT in maintaining cell viability was similar to that of water (P &gt; 0.05).	Water	299-304	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	107-110
27345527-1	2016	A polysaccharide fraction, here called POP1, was purified from the leaves of Platycladus orientalis (L.) Franco by water extraction and alcohol precipitation.	Water	115-120	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	39-43
27373895-3	2016	Upon blue-light irradiation, complex [3](PF6 )2 releases the cholesterol-thioether ligand 2 and an aqua ruthenium complex [1](PF6 )2 .	Water	99-103	sperm associated antigen 17	Homo sapiens	41-44
26971623-4	2016	The crystal and molecular structure of [{(eta(6)-p-cymene)Ru}2(mu(2)-alpha-alahaH-1)(H2O)Br]Br H2O (1) and [{(eta(6)-p-cymene)Ru}2(mu(2)-alpha-alahaH-1)(H2O)Cl]BF4 H2O (2) was determined by single crystal X-ray diffraction method.	Water	85-88	endothelin receptor type A	Homo sapiens	42-45
27037876-0	2016	Assessing the relation between anthropogenic pressure and PAH concentrations in surface water in the Seine River basin using multivariate analysis.	Water	88-93	phenylalanine hydroxylase	Homo sapiens	58-61
26992666-7	2016	A comparison of water quality in shallow and deep monitoring wells showed a more dramatic performance reduction in the deeper section of the concrete PRB, which was attributed to an influx of sediment into the barrier and settling of particulates from the upper portions of the PRBs.	Water	16-21	RB transcriptional corepressor 1	Homo sapiens	150-153
27373895-3	2016	Upon blue-light irradiation, complex [3](PF6 )2 releases the cholesterol-thioether ligand 2 and an aqua ruthenium complex [1](PF6 )2 .	Water	99-103	sperm associated antigen 17	Homo sapiens	126-129
28631388-7	2018	RESULTS: There was no significant difference in cell viability amongst HBSS, SAT and EMT groups up to 6 h. SAT was effective in maintaining cell viability only up to 12 h and then became detrimental to HPDLF; after 24 h, the effectiveness of SAT in maintaining cell viability was similar to that of water (P &gt; 0.05).	Water	299-304	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	107-110
27347685-3	2016	The dry etching of single-layer SiO2 nanosphere-coated GaN produces a pyramidal shape of the GaN, making the pores open at both sides and shortening the escape path of evolved gas bubbles produced inside pores during the water oxidation.	Water	221-226	gigaxonin	Homo sapiens	55-58
27272082-9	2016	Transepidermal water loss was reduced for the EGF/RHA over the TNS at week 12 (&lt;em&gt;P&lt;/em&gt; =0.005).	Water	15-20	HCL2	Homo sapiens	50-53
28887202-0	2018	Hospital sewage water: a reservoir for variants of New Delhi metallo-beta-lactamase (NDM)- and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae.	Water	16-21	New Delhi metallo-beta-lactamase	Escherichia coli	51-83
27347685-3	2016	The dry etching of single-layer SiO2 nanosphere-coated GaN produces a pyramidal shape of the GaN, making the pores open at both sides and shortening the escape path of evolved gas bubbles produced inside pores during the water oxidation.	Water	221-226	gigaxonin	Homo sapiens	93-96
29925711-9	2018	The decrease in salivary pH was significantly suppressed after water gargling in Exp.	Water	63-68	muscleblind like splicing regulator 1	Homo sapiens	81-84
27462276-3	2016	Therefore, the present study aimed to test the hypothesis that DPPIV inhibition by vildagliptin improves renal water and salt handling and exerts anti-proteinuric effects in rats with established HF.	Water	111-116	dipeptidylpeptidase 4	Rattus norvegicus	63-68
29925711-12	2018	Dilution of the sports drink had an interactive effect with water gargling in Exp.	Water	60-65	muscleblind like splicing regulator 1	Homo sapiens	78-81
27109604-9	2016	Interestingly, the Phe220Ala mutation in the transmembrane domain 5 of PIP1;2 activated its water-channel activity and, at the same time, inactivated PIP2;5 within a heterotetramer.	Water	92-97	aquaporin PIP1-2	Zea mays	71-77
26754561-1	2016	Mitochondrial cytochrome c oxidase utilizes electrons provided by cytochrome c for the active vectorial transport of protons across the inner mitochondrial membrane through the reduction of molecular oxygen to water.	Water	210-215	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	14-34
29199425-1	2017	Coumarin 6 (C6) briskly aggregates in water, and as a result, rapidly loses fluorescence.	Water	38-43	complement C6	Homo sapiens	0-14
26754561-1	2016	Mitochondrial cytochrome c oxidase utilizes electrons provided by cytochrome c for the active vectorial transport of protons across the inner mitochondrial membrane through the reduction of molecular oxygen to water.	Water	210-215	LOC104968582	Bos taurus	14-26
27083257-6	2016	The affinity for C18/SCX-SPME for tested organic cations without Hbond capacities increased with longer alkyl chains, ranging from logarithmic fiber-water distribution coefficients (log Dfw) of 1.8 (benzylamine) to 5.8 (triflupromazine).	Water	149-154	scleraxis bHLH transcription factor	Homo sapiens	21-24
26988281-5	2016	We investigated insulin receptor activation in the ventral striatum of rats receiving water or 16% glucose either orally or intragastrically.	Water	86-91	insulin receptor	Rattus norvegicus	16-32
26939885-4	2016	The crystals diffracted to 1.75A presenting the highest resolution structure of a SOX/DNA complex presently available revealing water structure, structural adjustments at the DNA contact interface and non-canonical conformations of the DNA backbone.	Water	128-133	quiescin Q6 sulfhydryl oxidase 1	Mus musculus	82-85
27147445-2	2016	Imbibing seeds to a water content of 45% or greater prior to PEF treatment increased the glutathione level and activities of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and ascorbate peroxidase in the resultant seedlings, compared to untreated controls.	Water	20-25	glutathione-disulfide reductase	Homo sapiens	157-178
26842727-0	2016	Comprehensive study on critical micellar concentrations of SDS in acetonitrile-water solvents.	Water	79-84	serine dehydratase	Homo sapiens	59-62
29923387-0	2016	[Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury].	Water	26-31	aquaporin 1	Rattus norvegicus	53-64
29923387-12	2016	The mRNA and protein expressions of AQP1 in cerebral cortex were significantly decreased after hydrogen-rich water treatment [24-hour AQP1 mRNA (2-  Ct):5.40+-0.21 vs.7.50+-0.26, 24-hour AQP1 protein (gray value): 1.246+-0.137 vs.1.986+-0.110, both P &lt; 0.05].	Water	109-114	aquaporin 1	Rattus norvegicus	36-40
29923387-12	2016	The mRNA and protein expressions of AQP1 in cerebral cortex were significantly decreased after hydrogen-rich water treatment [24-hour AQP1 mRNA (2-  Ct):5.40+-0.21 vs.7.50+-0.26, 24-hour AQP1 protein (gray value): 1.246+-0.137 vs.1.986+-0.110, both P &lt; 0.05].	Water	109-114	aquaporin 1	Rattus norvegicus	134-138
29923387-12	2016	The mRNA and protein expressions of AQP1 in cerebral cortex were significantly decreased after hydrogen-rich water treatment [24-hour AQP1 mRNA (2-  Ct):5.40+-0.21 vs.7.50+-0.26, 24-hour AQP1 protein (gray value): 1.246+-0.137 vs.1.986+-0.110, both P &lt; 0.05].	Water	109-114	aquaporin 1	Rattus norvegicus	134-138
29923387-14	2016	Early treatment with an intraperitoneally injection of hydrogen-rich water is capable of attenuating the extent of TBI-induced up-regulation of AQP1 mRNA and protein, alleviating cerebral edema, and achieving its protective effects.	Water	69-74	aquaporin 1	Rattus norvegicus	144-148
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Water	35-40	fibroblast growth factor 21	Mus musculus	182-209
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Water	35-40	fibroblast growth factor 21	Mus musculus	211-216
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Water	42-47	fibroblast growth factor 21	Mus musculus	182-209
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Water	42-47	fibroblast growth factor 21	Mus musculus	211-216
27048724-1	2016	The only crystals that could be grown from racemic solutions of the PF6(-) salt of the resolvable cation [Ru(2,9-dimethyl-1,10-phenanthroline)2(dipyrido[3,2-d:2",3"-f]quinoxaline)](2+) have translational symmetry only (space group P1), contain nine independent sets of ions, and include numerous independent solvent molecules (11 acetone, one diethyl ether and possibly several water molecules).	Water	378-383	sperm associated antigen 17	Homo sapiens	68-71
27081266-8	2016	TSLP showed a decreased trend in both distilled water and thermomineral water bath groups.	Water	48-53	thymic stromal lymphopoietin	Mus musculus	0-4
27081266-8	2016	TSLP showed a decreased trend in both distilled water and thermomineral water bath groups.	Water	72-77	thymic stromal lymphopoietin	Mus musculus	0-4
27026206-8	2016	Over-expression of caspase-1 (the IL-1beta converting enzyme) and excessive reactive oxygen species (ROS) production in the hippocampus and prefrontal cortex (PFC) was successfully suppressed by hydrogen-rich water treatment.	Water	209-214	caspase 1	Mus musculus	19-28
27026206-8	2016	Over-expression of caspase-1 (the IL-1beta converting enzyme) and excessive reactive oxygen species (ROS) production in the hippocampus and prefrontal cortex (PFC) was successfully suppressed by hydrogen-rich water treatment.	Water	209-214	caspase 1	Mus musculus	34-60
26841310-6	2016	Our spectroscopic studies suggest that TsrM binds cobalamin in an uncharacteristic five-coordinate base-off/His-off conformation, whereby the dimethylbenzimidazole group is replaced by a non-nitrogenous ligand, which is likely a water molecule.	Water	229-234	TSRM	Homo sapiens	39-43
26866384-6	2016	In addition, the CH3CN-bound analogue, [Cu2(CH3CN)2(dpypp)2](BF4)2, was successfully mechanochemically converted to Cu-X by grinding with solid KX in the presence of a trace amount of assisting water.	Water	194-199	cut like homeobox 1	Homo sapiens	116-120
26711671-7	2016	In addition, the ceramide increasing effect of HA4 on skin in UVA-irradiated hairless mice was assessed by water content of stratum corneum (SC) and transepidermal water loss (TEWL) methods.	Water	107-112	keratin 33B	Mus musculus	47-50
26834178-5	2016	Although the total amount of mucilage was comparable with the wild type (WT), the partition between water-soluble and adherent layers was significantly altered in irx14-1, with redistribution from the adherent layer to the water-soluble layer.	Water	100-105	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	163-168
26834178-5	2016	Although the total amount of mucilage was comparable with the wild type (WT), the partition between water-soluble and adherent layers was significantly altered in irx14-1, with redistribution from the adherent layer to the water-soluble layer.	Water	223-228	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	163-168
26834178-6	2016	The monosaccharide composition analysis revealed that xylose content was significantly reduced in irx14-1 water-soluble and adherent mucilage compared with the WT.	Water	106-111	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	98-103
26834178-7	2016	The macromolecular characteristics of the water-soluble mucilage were modified in irx14-1 with a loss of the larger polymeric components.	Water	42-47	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	82-87
27239852-6	2016	Mitochondrion membrane potential was reduced, cytochrome released into the cytoplasm and caspase-9 and caspase-3 were significantly increased (P &lt; 0.01) after treatment with H(2)O(2).	Water	177-182	caspase 3	Rattus norvegicus	103-112
27275663-2	2016	The nanobubbles are created between graphene and mica by reducing intercalated water to hydrogen.	Water	79-84	MHC class I polypeptide-related sequence A	Homo sapiens	49-53
27131017-9	2016	The results suggested that both water and organic soluble fractions of dust caused cytotoxicity, oxidative damage, inflammatory response, and activation of AhR inducible genes, with organic extracts having higher potential to induce adverse effects on primary HCE cells.	Water	32-37	aryl hydrocarbon receptor	Homo sapiens	156-159
27254650-0	2016	The catalytic effect of water, water dimers and water trimers on H2S + (3)O2 formation by the HO2 + HS reaction under tropospheric conditions.	Water	24-29	heme oxygenase 2	Homo sapiens	94-97
27254650-0	2016	The catalytic effect of water, water dimers and water trimers on H2S + (3)O2 formation by the HO2 + HS reaction under tropospheric conditions.	Water	31-36	heme oxygenase 2	Homo sapiens	94-97
27254650-0	2016	The catalytic effect of water, water dimers and water trimers on H2S + (3)O2 formation by the HO2 + HS reaction under tropospheric conditions.	Water	31-36	heme oxygenase 2	Homo sapiens	94-97
27254650-1	2016	In this article, the reaction mechanisms of H2S + (3)O2 formation by the HO2 + HS reaction without and with catalyst X (X = H2O, (H2O)2 and (H2O)3) have been investigated theoretically at the CCSD(T)/6-311++G(3df,2pd)//B3LYP/6-311+G(2df,2p) level of theory, coupled with rate constant calculations by using conventional transition state theory.	Water	124-127	heme oxygenase 2	Homo sapiens	73-76
27254650-1	2016	In this article, the reaction mechanisms of H2S + (3)O2 formation by the HO2 + HS reaction without and with catalyst X (X = H2O, (H2O)2 and (H2O)3) have been investigated theoretically at the CCSD(T)/6-311++G(3df,2pd)//B3LYP/6-311+G(2df,2p) level of theory, coupled with rate constant calculations by using conventional transition state theory.	Water	130-133	heme oxygenase 2	Homo sapiens	73-76
27254650-1	2016	In this article, the reaction mechanisms of H2S + (3)O2 formation by the HO2 + HS reaction without and with catalyst X (X = H2O, (H2O)2 and (H2O)3) have been investigated theoretically at the CCSD(T)/6-311++G(3df,2pd)//B3LYP/6-311+G(2df,2p) level of theory, coupled with rate constant calculations by using conventional transition state theory.	Water	130-133	heme oxygenase 2	Homo sapiens	73-76
27254650-3	2016	Meanwhile, the catalytic effect of water, water dimers and water trimers is mainly taken from the contribution of a single water vapor molecule, since the total effective rate constant of HO2H2O + HS and H2OHO2 + HS reactions was, respectively, larger by 7-9 and 9-12 orders of magnitude than that of SH + HO2(H2O)2 and SH + HO2(H2O)3 reactions.	Water	35-40	heme oxygenase 2	Homo sapiens	188-191
27254650-3	2016	Meanwhile, the catalytic effect of water, water dimers and water trimers is mainly taken from the contribution of a single water vapor molecule, since the total effective rate constant of HO2H2O + HS and H2OHO2 + HS reactions was, respectively, larger by 7-9 and 9-12 orders of magnitude than that of SH + HO2(H2O)2 and SH + HO2(H2O)3 reactions.	Water	35-40	heme oxygenase 2	Homo sapiens	207-210
27254650-3	2016	Meanwhile, the catalytic effect of water, water dimers and water trimers is mainly taken from the contribution of a single water vapor molecule, since the total effective rate constant of HO2H2O + HS and H2OHO2 + HS reactions was, respectively, larger by 7-9 and 9-12 orders of magnitude than that of SH + HO2(H2O)2 and SH + HO2(H2O)3 reactions.	Water	42-47	heme oxygenase 2	Homo sapiens	188-191
27254650-3	2016	Meanwhile, the catalytic effect of water, water dimers and water trimers is mainly taken from the contribution of a single water vapor molecule, since the total effective rate constant of HO2H2O + HS and H2OHO2 + HS reactions was, respectively, larger by 7-9 and 9-12 orders of magnitude than that of SH + HO2(H2O)2 and SH + HO2(H2O)3 reactions.	Water	42-47	heme oxygenase 2	Homo sapiens	207-210
27254650-3	2016	Meanwhile, the catalytic effect of water, water dimers and water trimers is mainly taken from the contribution of a single water vapor molecule, since the total effective rate constant of HO2H2O + HS and H2OHO2 + HS reactions was, respectively, larger by 7-9 and 9-12 orders of magnitude than that of SH + HO2(H2O)2 and SH + HO2(H2O)3 reactions.	Water	42-47	heme oxygenase 2	Homo sapiens	188-191
27254650-3	2016	Meanwhile, the catalytic effect of water, water dimers and water trimers is mainly taken from the contribution of a single water vapor molecule, since the total effective rate constant of HO2H2O + HS and H2OHO2 + HS reactions was, respectively, larger by 7-9 and 9-12 orders of magnitude than that of SH + HO2(H2O)2 and SH + HO2(H2O)3 reactions.	Water	42-47	heme oxygenase 2	Homo sapiens	207-210
27254650-3	2016	Meanwhile, the catalytic effect of water, water dimers and water trimers is mainly taken from the contribution of a single water vapor molecule, since the total effective rate constant of HO2H2O + HS and H2OHO2 + HS reactions was, respectively, larger by 7-9 and 9-12 orders of magnitude than that of SH + HO2(H2O)2 and SH + HO2(H2O)3 reactions.	Water	42-47	heme oxygenase 2	Homo sapiens	188-191
27254650-3	2016	Meanwhile, the catalytic effect of water, water dimers and water trimers is mainly taken from the contribution of a single water vapor molecule, since the total effective rate constant of HO2H2O + HS and H2OHO2 + HS reactions was, respectively, larger by 7-9 and 9-12 orders of magnitude than that of SH + HO2(H2O)2 and SH + HO2(H2O)3 reactions.	Water	42-47	heme oxygenase 2	Homo sapiens	207-210
27409114-3	2016	Abrasive-free water-dissolution magnetorheological finishing is used in KDP figuring in our lab.	Water	14-19	WNK lysine deficient protein kinase 1	Homo sapiens	72-75
27196628-5	2016	At small insulator thickness, a record for a Schottky junction photoanode of 623 mV photovoltage is achieved, yielding a photocurrent turn-on at 0.92 V vs NHE or -0.303 V with respect to the thermodynamic potential for water oxidation.	Water	219-224	solute carrier family 9 member C1	Homo sapiens	155-158
27219867-0	2016	Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.	Water	16-21	TATA-box binding protein associated factor 1	Homo sapiens	65-69
27219867-0	2016	Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.	Water	16-21	bromodomain containing 9	Homo sapiens	74-78
26995650-0	2016	PGE2 receptor EP3 inhibits water reabsorption and contributes to polyuria and kidney injury in a streptozotocin-induced mouse model of diabetes.	Water	27-32	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	14-17
26995650-2	2016	The prostaglandin E2 (PGE2) receptor EP3 antagonises arginine vasopressin (AVP)-mediated water reabsorption and its expression is increased in the diabetic kidney.	Water	89-94	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	37-40
26995650-6	2016	RESULTS: Ep 3 (-/-)-STZ mice exhibited attenuated polyuria and increased urine osmolality compared with wild-type STZ (WT-STZ) mice, suggesting enhanced water reabsorption.	Water	153-158	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	9-13
26995650-9	2016	In WT non-injected and WT-STZ mice, EP3 activation with sulprostone (PGE2 analogue) abrogated AVP-mediated water reabsorption; this effect was absent in mice lacking EP3.	Water	107-112	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	36-39
27228426-1	2016	Herein we report a study on water adsorption/desorption-triggered single-crystal to single-crystal transformations in a MOF, by single-crystal and humidity-controlled powder X-ray diffraction and water-sorption measurements.	Water	28-33	lysine acetyltransferase 8	Homo sapiens	120-123
27228426-1	2016	Herein we report a study on water adsorption/desorption-triggered single-crystal to single-crystal transformations in a MOF, by single-crystal and humidity-controlled powder X-ray diffraction and water-sorption measurements.	Water	196-201	lysine acetyltransferase 8	Homo sapiens	120-123
27064286-6	2016	1D and 2D (1)H NMR studies revealed that in water, the longer chain (C6 and C8) alkyl groups in the hydrogel NPs were engaged in intrachain association, rendering them less available to interact with LPS.	Water	44-49	complement C6	Homo sapiens	69-78
26497277-3	2016	The identification of a water-filled pore that is mainly constituted by Pex5 and Pex14 led to the assumption that proteins are translocated through a large, probably transient, protein-conducting channel.	Water	24-29	peroxisomal biogenesis factor 5	Homo sapiens	72-76
29997800-1	2016	A highly luminescent and water-stable homochiral Zn-MOF, i.e., Zn-PLA, has been developed based on a pyrene-tetralactic acid, which inherently features concave shapes for guest inclusion, to explore sensing of amino acids by fluorescence quenching; the solid-state fluorescence quantum yield of the MOF was found to be 46%.	Water	25-30	lysine acetyltransferase 8	Homo sapiens	52-55
29997800-1	2016	A highly luminescent and water-stable homochiral Zn-MOF, i.e., Zn-PLA, has been developed based on a pyrene-tetralactic acid, which inherently features concave shapes for guest inclusion, to explore sensing of amino acids by fluorescence quenching; the solid-state fluorescence quantum yield of the MOF was found to be 46%.	Water	25-30	lysine acetyltransferase 8	Homo sapiens	299-302
26991533-2	2016	CLC-K chloride channels and their accessory subunit barttin play a pivotal role in kidney by controlling chloride and water absorption.	Water	118-123	barttin CLCNK type accessory subunit beta	Rattus norvegicus	52-59
27010186-2	2016	In this approach, elaborately controlling the reaction temperature and volume ratio of i-PrOH and H2O enabled TaF5 to transform into intermediate coordination complex ions of [TaOF3 2F](2-) and [TaF7](2-), which subsequently produced tantalum oxyfluoride ACHNs via a secondary nucleation and growth due to a stepwise change in hydrolysis rates of the two complex ions.	Water	98-101	TATA-box binding protein associated factor 7	Homo sapiens	195-199
27117219-10	2016	The HBP significantly influenced the water sorption and solubility of the neat resin(P&lt;0.05).	Water	37-42	heme binding protein 1	Homo sapiens	4-7
26934836-1	2016	Sub-20 nm core-shell and water-soluble SrF2:Yb,Tm@CaF2:Gd heteronanoparticles with both upconversion luminescence (UCL) and magnetic resonance imaging (MRI) capabilities were designed and synthesized via a two-step hydrothermal method.	Water	25-30	CCR4-NOT transcription complex subunit 8	Homo sapiens	50-54
26841230-9	2016	Fulvic acid and turbidity in water reduced TOX photodegradation.	Water	29-34	thymocyte selection associated high mobility group box	Homo sapiens	43-46
26985956-7	2016	Porcine EFNB2 is a water-soluble protein with a theoretical molecular weight of 36,928.1 Da, an isoelectric point of 8.98, and a hydrophilic transmembrane-spanning region.	Water	19-24	ephrin B2	Sus scrofa	8-13
26854536-1	2016	The inositol polyphosphate 5-phosphatase INPP5B hydrolyzes the 5-phosphate group from water- and lipid-soluble signaling messengers.	Water	86-91	inositol polyphosphate-5-phosphatase B	Homo sapiens	41-47
26788555-7	2016	Oseltamivir-conjugated water soluble pPEGMEMA, dose dependently, both inhibited sialidase activity associated with Neu1, and reduced viability of PANC1 cells.	Water	23-28	neuraminidase 1	Homo sapiens	115-119
26250106-6	2016	It was confirmed that the precipitate that was formed by zinc ions in the presence of HPbetaCD and DF-Na contained no cyclodextrin and most likely it was a mixture of the complexes: DF2-Zn and DF-Zn with some molecules of water.	Water	222-227	serine protease 57	Rattus norvegicus	182-185
26988683-1	2016	OBJECTIVE: To investigate the relationship between blood aryl hydrocarbon receptor(AhR)mRNA and cytochrome P450(CYP)1A1 mRNA expression and corrected QT interval among residents exposed to arsenic via drinking water.	Water	210-215	aryl hydrocarbon receptor	Homo sapiens	57-82
26988683-1	2016	OBJECTIVE: To investigate the relationship between blood aryl hydrocarbon receptor(AhR)mRNA and cytochrome P450(CYP)1A1 mRNA expression and corrected QT interval among residents exposed to arsenic via drinking water.	Water	210-215	aryl hydrocarbon receptor	Homo sapiens	83-86
27019634-8	2016	We also demonstrated that intracerebroventricular injection of GSK-3beta siRNA in rats ameliorated neurological deficits, reduced brain infarct volume and water content, and reduced damage to cerebral cortical neurons after MCAO.	Water	155-160	glycogen synthase kinase 3 beta	Rattus norvegicus	63-72
29295550-2	2017	Drinking and recreational water contaminated with Cryptosporidium spp.	Water	26-31	histocompatibility minor 13	Homo sapiens	66-69
26955272-5	2016	PEDF gene loaded CPPC nanoparticles (D-NPs) were fabricated by a modified double-emulsion water-in-oil-in-water (W/O/W) solvent evaporation method.	Water	90-95	serpin family F member 1	Homo sapiens	0-4
26955272-5	2016	PEDF gene loaded CPPC nanoparticles (D-NPs) were fabricated by a modified double-emulsion water-in-oil-in-water (W/O/W) solvent evaporation method.	Water	106-111	serpin family F member 1	Homo sapiens	0-4
26887358-5	2016	According to these mechanisms, we suggest that a water-miscible tetraphenylethene BSPOTPE is a potent inhibitor to rescue hIAPP-induced cytotoxicity.	Water	49-54	islet amyloid polypeptide	Homo sapiens	122-127
26887358-7	2016	The micelle-like hIAPP-BSPOTPE clusters tend to be retained in the water/membrane interface and aggregate therein rather than penetrate into the membrane.	Water	67-72	islet amyloid polypeptide	Homo sapiens	17-22
26847163-7	2016	On average, a single piH-bond is found to be formed between water and benzene in the 45  axial conical region of the solvation shell.	Water	60-65	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	21-24
29035854-7	2017	This investigation provides further evidence that the T4 genotype is the most prevalent in water samples and demonstrates that there is a need for taking more consideration to water sources in order to prevent complications associated with pathogenic Acanthamoeba spp.	Water	176-181	histocompatibility minor 13	Homo sapiens	264-267
26847163-8	2016	The piH-bonded water molecules are found to have faster translational dynamics and also found to follow a fast jump mechanism of reorientation to change their hydrogen bonded partners.	Water	15-20	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	4-7
26850728-6	2016	RESULTS: Spinal water content and EB extravasation were suggested as a bimodal distribution in directly proportion to AQP1, since all maximal changes were detected at 12 and 48 h after reperfusion.	Water	16-21	aquaporin 1	Rattus norvegicus	118-122
29210372-2	2017	Herein, a novel tumor-targeting Magnetic Resonance Imaging (MRI) contrast agent was developed based on Mn2+-chelating ultrasmall water-soluble melanin nanoparticles (MNP-PEG-Mn).	Water	129-134	modifier of Niemann Pick type C1	Mus musculus	166-169
26727708-0	2016	Comparative Study of Water Adsorption on a H(+) and K(+) Ion Exposed Mica Surface: Monte Carlo Simulation Study.	Water	21-26	MHC class I polypeptide-related sequence A	Homo sapiens	69-73
26727708-3	2016	We investigated the role of surface ions in the adsorption of water molecules by using a muscovite mica surface populated with two different, H(+) and K(+), surface ions.	Water	62-67	MHC class I polypeptide-related sequence A	Homo sapiens	99-103
27458325-2	2016	The ABC block copolypeptoids undergo sol-to-gel transitions with increasing temperature in water and biological media at low concentrations (2.5-10 wt %).	Water	91-96	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	4-7
26727708-4	2016	A series of grand canonical Monte Carlo (GCMC) simulations at various relative vapor pressures (p/p0) were performed to obtain the water structure and adsorption isotherm on the H(+)-exposed mica (H-mica) surface.	Water	131-136	MHC class I polypeptide-related sequence A	Homo sapiens	191-195
28898779-1	2017	Microbial desalination cell (MDC) is a new approach of water desalination methods, which is based on ionic species removal from water in proportion to the electric current generated by bacteria.	Water	55-60	C-C motif chemokine ligand 22	Homo sapiens	29-32
26727708-5	2016	The obtained results were compared to the recent simulation data of water adsorption on the K(+)-exposed mica (K-mica) surface reported by Malani and Ayyappa (Malani, A.; Ayappa, K. G. J. Phys.	Water	68-73	MHC class I polypeptide-related sequence A	Homo sapiens	105-109
26727708-5	2016	The obtained results were compared to the recent simulation data of water adsorption on the K(+)-exposed mica (K-mica) surface reported by Malani and Ayyappa (Malani, A.; Ayappa, K. G. J. Phys.	Water	68-73	MHC class I polypeptide-related sequence A	Homo sapiens	113-117
26727708-8	2016	Water molecules formed two prominent layers adjacent to the H-mica surface, whereas molecular layering was observed adjacent to the K-mica surface.	Water	0-5	MHC class I polypeptide-related sequence A	Homo sapiens	62-66
26727708-9	2016	The adsorption isotherm of water on the K-mica surface was characterized by three stages that corresponded to rapid adsorption in the initial regime below p/p0 = 0.1, followed by a linear development regime for p/p0 = 0.1-0.7 and rapid film thickening for p/p0 &gt;= 0.7, whereas only latter two regimes were observed in the H-mica system.	Water	27-32	MHC class I polypeptide-related sequence A	Homo sapiens	42-46
26727708-9	2016	The adsorption isotherm of water on the K-mica surface was characterized by three stages that corresponded to rapid adsorption in the initial regime below p/p0 = 0.1, followed by a linear development regime for p/p0 = 0.1-0.7 and rapid film thickening for p/p0 &gt;= 0.7, whereas only latter two regimes were observed in the H-mica system.	Water	27-32	MHC class I polypeptide-related sequence A	Homo sapiens	327-331
26546505-7	2016	The volume of the brain edema lesion and the water content of the brain were significantly increased in mice treated with AK-7 (20 mg/kg), compared with the vehicle group, following TBI (p &lt; 0.05 at 1 day and p &lt; 0.05 at 3 days, respectively).	Water	45-50	adenylate kinase 7	Mus musculus	122-126
28766956-5	2017	However, KCN1 and its earlier analogs have poor water solubility, which hamper their applications.	Water	48-53	potassium voltage-gated channel subfamily A member 10	Homo sapiens	9-13
26653463-5	2016	hIAPP(11-20) displayed similar self-aggregation in both HEPES and pure water.	Water	71-76	islet amyloid polypeptide	Homo sapiens	0-5
26727708-10	2016	In addition, the film thickness of adsorbed water molecules for p/p0 &lt; 0.7 was lower as compared to that for the K-mica surface and comparable beyond.	Water	44-49	MHC class I polypeptide-related sequence A	Homo sapiens	118-122
26660873-4	2016	The CuI block imparts water stability to the host; with the tunable luminescence from the lanthanide ions, this creates the first white-emitting MOF that is stable in boiling water.	Water	22-27	lysine acetyltransferase 8	Homo sapiens	145-148
27433728-6	2016	The solubility of OXA in water was approximately 7.07 mg/mL, whereas the water solubility of OXA/DCK was approximately 2.04 mg/mL and its partition coefficient was approximately 1.2-fold higher than that of OXA.	Water	73-78	deoxycytidine kinase	Homo sapiens	97-100
28766956-7	2017	We found that replacing the benzopyran group of KCN1 with a phenyl group with a morpholinomethyl moiety at the para positions had minimal effect on potency and improved the water solubility of two new compounds by more than 10-fold compared to KCN1, the lead compound.	Water	173-178	potassium voltage-gated channel subfamily A member 10	Homo sapiens	48-52
26660873-4	2016	The CuI block imparts water stability to the host; with the tunable luminescence from the lanthanide ions, this creates the first white-emitting MOF that is stable in boiling water.	Water	175-180	lysine acetyltransferase 8	Homo sapiens	145-148
29542267-5	2017	The kmWap65-1 gene showed sequence homology with teleost Wap65-1 and mammalian hemopexin, and was highly expressed in response to increased water temperature and bacterial lipopolysaccharide (LPS) exposure.	Water	140-145	hemopexin	Homo sapiens	79-88
26586115-5	2016	These compounds also displayed different AIE performances: when the fraction of water in the THF solutions of these compounds was increased, we observed a significant improvement in the PhiF of compounds SAF-2-TriPE and SAF-3-TriPE; in contrast, compound SAF-4-TriPE showed an abnormal phenomenon, in that it emitted a strong fluorescence in both pure THF solution and in the aggregated state without a significant change in PhiF .	Water	80-85	MYC associated zinc finger protein	Homo sapiens	220-225
26822858-4	2016	Compared to incubations with normal (5 mmol/L) glucose concentrations, cells exposed to both high glucose and high mannitol (at 30.5 or 50.5 mmol/L) increased expression of the water channel aquaporin-1 (AQP1) and cyclooxygenase (COX)-2.	Water	177-182	aquaporin 1	Mus musculus	204-208
26822858-4	2016	Compared to incubations with normal (5 mmol/L) glucose concentrations, cells exposed to both high glucose and high mannitol (at 30.5 or 50.5 mmol/L) increased expression of the water channel aquaporin-1 (AQP1) and cyclooxygenase (COX)-2.	Water	177-182	cytochrome c oxidase II, mitochondrial	Mus musculus	214-236
26587568-4	2016	Herein, a water-soluble curcumin derivative, CurDAc, is used to investigate the mitigation of hIAPP aggregation in the absence and presence of lipid membrane.	Water	10-15	islet amyloid polypeptide	Homo sapiens	94-99
32262957-0	2016	Reverse micelles-in-microspheres with sustained release of water-soluble combretastatin A4 phosphate for S180 tumor treatment.	Water	59-64	carbonic anhydrase 4	Homo sapiens	73-90
29030969-7	2017	It is shown that adropin reduced brain water content and improved neurological functions.	Water	39-44	energy homeostasis associated	Mus musculus	17-24
32262957-1	2016	Combretastatin A4 phosphate (CA4P), the water-soluble phosphate pro-drug of combretastatin A4 (CA4), acts as a novel vascular disrupting agent (VDA).	Water	40-45	carbonic anhydrase 4	Homo sapiens	0-17
32262957-1	2016	Combretastatin A4 phosphate (CA4P), the water-soluble phosphate pro-drug of combretastatin A4 (CA4), acts as a novel vascular disrupting agent (VDA).	Water	40-45	carbonic anhydrase 4	Homo sapiens	29-32
29143044-3	2017	Herein, we report a cobalt-based robust homogeneous water oxidation catalyst, which can electrocatalyze water oxidation at a high pH and a low overpotential (eta = 520 mV) in phosphate buffer.	Water	52-57	endothelin receptor type A	Homo sapiens	158-161
26615669-5	2016	Under light illumination, PSII can split water into protons, oxygen, and electrons and can generate a proton gradient for ATPase to produce ATP.	Water	41-46	dynein axonemal heavy chain 8	Homo sapiens	122-128
26663535-6	2016	We found that the HexNAc-derived m/z 126 and 144 oxonium ions, differing in mass by H2 O, had completely different structures and that high-mannose N-glycopeptides generated abundant Hex-derived oxonium ions.	Water	84-88	hematopoietically expressed homeobox	Homo sapiens	18-21
29143044-3	2017	Herein, we report a cobalt-based robust homogeneous water oxidation catalyst, which can electrocatalyze water oxidation at a high pH and a low overpotential (eta = 520 mV) in phosphate buffer.	Water	104-109	endothelin receptor type A	Homo sapiens	158-161
26808839-0	2016	Water First Aid Is Beneficial In Humans Post-Burn: Evidence from a Bi-National Cohort Study.	Water	0-5	activation induced cytidine deaminase	Homo sapiens	12-15
29143044-4	2017	This homogeneous system exhibits a high turnover frequency (about 5 s-1) of catalyzing water oxidation to produce oxygen at eta = 720 mV.	Water	87-92	endothelin receptor type A	Homo sapiens	124-127
26808839-3	2016	The current recommendation for optimum first aid after burn is water cooling for 20 minutes within three hours.	Water	63-68	activation induced cytidine deaminase	Homo sapiens	45-48
26415878-8	2016	Furthermore, structures of wild type and mutant GUSBp were subjected to molecular dynamics simulation to examine the relative structural behaviors in the explicit conditions of water.	Water	177-182	glucuronidase beta	Homo sapiens	48-53
29023730-0	2017	CrossTalk opposing view: proton transfer in Hv1 utilizes a water wire, and does not require transient protonation of a conserved aspartate in the S1 transmembrane helix.	Water	59-64	hydrogen voltage gated channel 1	Homo sapiens	44-47
26808839-6	2016	The aim of the study was to quantify the magnitude of effects of water cooling first aid after burn on indicators of burn severity in a large human cohort.	Water	65-70	activation induced cytidine deaminase	Homo sapiens	85-88
26653077-1	2016	Recently we presented structure-reactivity correlations for the gas-phase ambient-temperature rate constants for hydrogen abstraction from sp(3)-hybridized carbon by chlorine atom and hydroxyl radical (Cl /HO  + HCR3   HCl/HOH +  CR3); the reaction enthalpy effect was represented by the independent variable DeltarH and the "polar effect" by the independent variables F and R, the Hammett constants for field/inductive and resonance effects.	Water	223-226	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	213-216
26468603-3	2016	UV-C light (254 nm wavelength, 40 W power) was applied to BPA contaminated water at natural pH (pHN) under room temperature conditions.	Water	75-80	carbamoyl-phosphate synthase 1	Homo sapiens	96-99
29123088-0	2017	A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer.	Water	2-7	nucleolin	Homo sapiens	16-25
26760974-1	2016	The water channel aquaporin-1 (AQP1) mediates about 50% ultrafiltration during a 2-hour hypertonic dwell in global AQP1 knockout (AQP1-/-) mice.	Water	4-9	aquaporin 1	Mus musculus	31-35
26760974-1	2016	The water channel aquaporin-1 (AQP1) mediates about 50% ultrafiltration during a 2-hour hypertonic dwell in global AQP1 knockout (AQP1-/-) mice.	Water	4-9	aquaporin 1	Mus musculus	115-119
26556064-7	2016	Interestingly, animals receiving CORT via injection or drinking water had lower numbers of doublecortin-positive cells in the ventral DG one week after the last CORT administration compared to animals implanted with a CORT pellet.	Water	64-69	cortistatin	Rattus norvegicus	161-165
29123088-3	2017	Here we design and synthesize a highly water-soluble nucleolin aptamer-paclitaxel conjugate (NucA-PTX) that selectively delivers PTX to the tumor site.	Water	39-44	nucleolin	Homo sapiens	53-62
26556064-7	2016	Interestingly, animals receiving CORT via injection or drinking water had lower numbers of doublecortin-positive cells in the ventral DG one week after the last CORT administration compared to animals implanted with a CORT pellet.	Water	64-69	cortistatin	Rattus norvegicus	161-165
26760974-1	2016	The water channel aquaporin-1 (AQP1) mediates about 50% ultrafiltration during a 2-hour hypertonic dwell in global AQP1 knockout (AQP1-/-) mice.	Water	4-9	aquaporin 1	Mus musculus	115-119
26760974-6	2016	During a 1-hour 3.86% mini-peritoneal equilibration test (mini-PET), AQP1fl/fl; Cdh5-Cre+ mice exhibited strongly decreased indices for AQP1-related transcellular water transport (43.0% in net ultrafiltration, 93.0% in sodium sieving and 57.9% in free water transport) compared to controls.	Water	163-168	aquaporin 1	Mus musculus	69-73
26760974-6	2016	During a 1-hour 3.86% mini-peritoneal equilibration test (mini-PET), AQP1fl/fl; Cdh5-Cre+ mice exhibited strongly decreased indices for AQP1-related transcellular water transport (43.0% in net ultrafiltration, 93.0% in sodium sieving and 57.9% in free water transport) compared to controls.	Water	163-168	aquaporin 1	Mus musculus	136-140
26760974-6	2016	During a 1-hour 3.86% mini-peritoneal equilibration test (mini-PET), AQP1fl/fl; Cdh5-Cre+ mice exhibited strongly decreased indices for AQP1-related transcellular water transport (43.0% in net ultrafiltration, 93.0% in sodium sieving and 57.9% in free water transport) compared to controls.	Water	252-257	aquaporin 1	Mus musculus	136-140
29052412-0	2017	Co(II)-Doped Cd-MOF as an Efficient Water Oxidation Catalyst: Doubly Interpenetrated Boron Nitride Network with the Encapsulation of Free Ligand Containing Pyridine Moieties.	Water	36-41	lysine acetyltransferase 8	Homo sapiens	16-19
26611638-7	2016	Additionally, Li-doped single-layer SnS2 is active for overall water splitting under visible light radiation whereas Mg and Al-doped SnS2 are only suitable for oxygen evolution.	Water	63-68	sodium voltage-gated channel alpha subunit 11	Homo sapiens	36-40
26760974-6	2016	During a 1-hour 3.86% mini-peritoneal equilibration test (mini-PET), AQP1fl/fl; Cdh5-Cre+ mice exhibited strongly decreased indices for AQP1-related transcellular water transport (43.0% in net ultrafiltration, 93.0% in sodium sieving and 57.9% in free water transport) compared to controls.	Water	252-257	aquaporin 1	Mus musculus	69-73
26502791-1	2016	We herein report a water-stable 3D dysprosium-based metal-organic framework (MOF) that can non-covalently interact with probe ss-DNA.	Water	19-24	lysine acetyltransferase 8	Homo sapiens	52-81
29052412-4	2017	CoCd-MOF exhibited very high catalytic activity in water oxidation reaction.	Water	51-56	lysine acetyltransferase 8	Homo sapiens	5-8
28777991-2	2017	An increase in water flux was observed when an external voltage was applied to the FO equipped with the PEM; as expected, the trend became more dramatic with both concentration of draw solution and applied voltage raised.	Water	15-20	mucin 1, cell surface associated	Homo sapiens	104-107
26288996-6	2016	It was confirmed that the precipitate that was formed by zinc ions in the presence of HPbetaCD and DF-Na contained no cyclodextrin and most likely it was a mixture of the complexes: DF2-Zn and DF-Zn with some molecules of water.	Water	222-227	serine protease 57	Rattus norvegicus	182-185
28787638-5	2017	The results of heating of a treated water in the presence of residuals showed that TOX concentrations of chlorinated samples increased rapidly when chlorine residuals were present and then gradually decreased after chlorine residuals were exhausted.	Water	36-41	thymocyte selection associated high mobility group box	Homo sapiens	83-86
25811939-11	2016	High mountain stream water sub-catchments dominated by nearly undisturbed forest and grassland contribute nitrate with delta(15)NNO3 and delta(18)ONO3 values of -1 and -3.5 %, respectively.	Water	21-26	NNO3	Homo sapiens	128-132
28602994-3	2017	Subcritical water-hydrolyzed fish collagen peptide (SWFCP) significantly inhibited lipid accumulation during the differentiation of 3T3-L1 preadipocytes, which was accompanied by decreased expression of CCAAT-enhancer-binding protein-alpha (C/EBP-alpha), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and adipocyte protein 2 (aP2) genes, key regulators of differentiation and maintenance of adipocytes.	Water	12-17	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	241-252
26649316-5	2016	We find that the adsorption of hIAPP to POPC bilayer is mainly initiated from the C-terminal region and the peptide adopts a helical structure with multiple binding orientations, while the adsorption to POPG bilayer is mostly initiated from the N-terminal region and hIAPP displays one preferential binding orientation, with its hydrophobic residues exposed to water.	Water	361-366	islet amyloid polypeptide	Homo sapiens	31-36
28602994-3	2017	Subcritical water-hydrolyzed fish collagen peptide (SWFCP) significantly inhibited lipid accumulation during the differentiation of 3T3-L1 preadipocytes, which was accompanied by decreased expression of CCAAT-enhancer-binding protein-alpha (C/EBP-alpha), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and adipocyte protein 2 (aP2) genes, key regulators of differentiation and maintenance of adipocytes.	Water	12-17	peroxisome proliferator activated receptor gamma	Mus musculus	305-315
31966420-5	2017	We demonstrated that Abeta peptide and H2O2 treatment could result in the translocation of RXRalpha and Nur77 from the nucleus to the mitochondria, and the ligand of RXR, 9-cis-RA, treatment can block the above phenomenon.	Water	39-43	retinoid X receptor alpha	Mus musculus	91-99
26480200-0	2016	Electrolytically generated acid functional water inhibits NF-kappaB activity by attenuating nuclear-cytoplasmic shuttling of p65 and p50 subunits.	Water	43-48	RELA proto-oncogene, NF-kB subunit	Homo sapiens	125-128
27508374-2	2016	In previous studies, DPS could be reliably estimated from water-soluble P (WSP) for European and Brazilian soils.	Water	58-63	decaprenyl diphosphate synthase subunit 1	Homo sapiens	21-24
29107287-13	2017	When FGF21-KO mice consumed 30% ethanol in drinking water, along with a normal chow diet, there was no mortality observed even after 16 weeks, but the FGF21-KO mice had significant liver pathology compared to WT mice.	Water	52-57	fibroblast growth factor 21	Mus musculus	5-13
27508381-10	2016	Ozonation of secondary wastewater attained the South African water standards in terms of COD required for wastewater discharge and dissolved organic carbon in drinking water and increased significantly the biodegradability of primary wastewater.	Water	28-33	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	89-92
28898570-1	2017	Considering the sizable band gap and wide spectrum response of tin disulfide (SnS2 ), ultrathin SnS2 nanosheets are utilized as solar-driven photocatalyst for water splitting.	Water	159-164	sodium voltage-gated channel alpha subunit 11	Homo sapiens	78-82
27197485-0	2016	[Effects of AQP1 overexpression on morphology and water transport in mouse Schwann cells].	Water	50-55	aquaporin 1	Mus musculus	12-16
27197485-9	2016	CONCLUSIONS: AQP1 is an important factor responsible for the fast water transport of cultured Schwann cells.	Water	66-71	aquaporin 1	Mus musculus	13-17
28898570-1	2017	Considering the sizable band gap and wide spectrum response of tin disulfide (SnS2 ), ultrathin SnS2 nanosheets are utilized as solar-driven photocatalyst for water splitting.	Water	159-164	sodium voltage-gated channel alpha subunit 11	Homo sapiens	96-100
29089526-2	2017	Enormous fresh water flux into the BoB and consequent salinity stratification significantly weaken the convective mixing and wind driven processes which are commonly responsible for transport of nutrients to the euphotic zone driving primary productivity.	Water	15-20	G protein-coupled receptor 15	Homo sapiens	35-38
26639216-2	2015	A simple, cheap and accessible electrospinning method was employed to prepare a water stable CH3MOF-5/PAN composite.	Water	80-85	adenosine deaminase 2	Homo sapiens	102-105
29058608-6	2017	Phosphoproteome characterization of SGBPs under water-deficit treatment demonstrated a reduced level of phosphorylation of main starch synthesis enzymes, particularly for granule-bound starch synthase (GBSS I), starch synthase II-a (SS II-a), and starch synthase III (SS III).	Water	48-53	soluble starch synthase 2-3, chloroplastic/amyloplastic	Triticum aestivum	211-231
26675475-0	2015	Subcritical Water Hydrolysis Effectively Reduces the In Vitro Seeding Activity of PrPSc but Fails to Inactivate the Infectivity of Bovine Spongiform Encephalopathy Prions.	Water	12-17	prion protein	Mus musculus	82-87
28899515-0	2017	The water extract of Liuwei dihuang possesses multi-protective properties on neurons and muscle tissue against deficiency of survival motor neuron protein.	Water	4-9	survival motor neuron 1	Mus musculus	125-154
26568062-3	2015	Herein we reveal that a 2.5 nm-sized, fullerene-shaped molecular cluster Li48+m K12(OH)m [UO2(O2)(OH)]60-(H2O)n (m   20 and n   310) (U60) shows selective permeability to different alkali ions.	Water	106-109	small nucleolar RNA, C/D box 60	Homo sapiens	134-137
26568062-4	2015	The subnanometer pores on the water-ligand-rich surface of U60 are able to block Rb(+) and Cs(+) ions from passing through, while allowing Na(+) and K(+) ions, which possess larger hydrated sizes, to enter the interior space of U60.	Water	30-35	small nucleolar RNA, C/D box 60	Homo sapiens	59-62
26568062-4	2015	The subnanometer pores on the water-ligand-rich surface of U60 are able to block Rb(+) and Cs(+) ions from passing through, while allowing Na(+) and K(+) ions, which possess larger hydrated sizes, to enter the interior space of U60.	Water	30-35	small nucleolar RNA, C/D box 60	Homo sapiens	228-231
28807355-12	2017	These results demonstrated that H2-rich pure water attenuated CS-induced emphysema in SMP30-KO mice by reducing CS-induced oxidative DNA damage and premature cell senescence in the lungs.	Water	45-50	regucalcin	Mus musculus	86-91
28535987-1	2017	A novel three-chambered microbial desalination cell (MDC) was designed for evaluating desalination of synthetic ground water with simultaneous energy generation and resource recovery.	Water	119-124	C-C motif chemokine ligand 22	Homo sapiens	53-56
26659061-0	2015	Erratum for the Research Article ""Water-in-salt" electrolyte enables high-voltage aqueous lithium-ion chemistries" by Liumin Suo, Oleg Borodin, Tao Gao, Marco Olguin, Janet Ho, Xiulin Fan, Chao Luo, Chunsheng Wang, Kang Xu.	Water	35-40	macrophage receptor with collagenous structure	Homo sapiens	154-159
28535987-7	2017	MDC can function as sustainable and alternative solution for ground and surface water treatment with power productivity and resource recovery.	Water	80-85	C-C motif chemokine ligand 22	Homo sapiens	0-3
28111811-4	2017	Combining imiquimod with detergent-containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP3 or AQP3 and AQP10.	Water	46-51	aquaporin 10	Homo sapiens	188-193
26257077-3	2015	This strategy, coupled with the high water stability of the materials, led to enhanced MOF-driven photocatalytic degradation, under ultraviolet-visible light, of organic dye pollutants commonly found in wastewater.	Water	37-42	lysine acetyltransferase 8	Homo sapiens	87-90
28527993-4	2017	The derivative modified by sodium metaphosphate (J-5) was easily hydrated in water and had extremely low viscosity.	Water	77-82	immunoglobulin kappa joining 5	Homo sapiens	49-52
26358135-1	2015	PURPOSE: The 4,5-diarylimidazole brimamin is an analog of the natural vascular-disrupting agent combretastatin A-4 (CA-4) with improved water solubility, tolerance by animals and efficacy in multidrug-resistant tumors.	Water	136-141	carbonic anhydrase 4	Homo sapiens	116-120
28726316-0	2017	Deprotonation states of the two active site water molecules regulate the binding of protein phosphatase 5 with its substrate: A molecular dynamics study.	Water	44-49	protein phosphatase 5 catalytic subunit	Homo sapiens	84-105
26297350-3	2015	To test our hypothesis that peripheral and hypothalamic nesfatin-1 overexpression should play an important role in the stress response and the associated hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis, acute stress (AS) was induced using water avoidance stress (WAS), and chronic unpredictable mild stress (CUMS) was also induced using 3 consecutive weeks of 7 different stressors.	Water	250-255	nucleobindin 2	Rattus norvegicus	56-66
26298003-11	2015	First acetaldehyde indirectly activates AT1R in the dipsogenic centers via the peripheral renin-angiotensin system following the depressor response and induces both water and salt intake.	Water	165-170	angiotensin II receptor, type 1a	Rattus norvegicus	40-44
28726316-5	2017	The theoretical study gives us an insight into the catalytic mechanism of PP5, but the knowledge of how the deprotonation states of the two water molecules affect the binding of PP5 with its substrate is still lacking.	Water	140-145	protein phosphatase 5 catalytic subunit	Homo sapiens	74-77
26845138-3	2016	Previous studies showed that disodium phosphate salt of CA-4, a water-soluble prodrug is well tolerated at therapeutically useful doses.	Water	64-69	carbonic anhydrase 4	Homo sapiens	56-60
28726316-5	2017	The theoretical study gives us an insight into the catalytic mechanism of PP5, but the knowledge of how the deprotonation states of the two water molecules affect the binding of PP5 with its substrate is still lacking.	Water	140-145	protein phosphatase 5 catalytic subunit	Homo sapiens	178-181
26488458-10	2015	The 30% ethanol dramatically accelerated the adsorption of Cytc on the water surface.	Water	71-76	LOC104968582	Bos taurus	59-63
28934248-8	2017	Intriguingly, cell surface targeting of SLC4A11, a membrane transport protein (OH- /H+ /NH3 /H2O) of corneal endothelium, whose mutations have been identified in patients with corneal dystrophy, was impaired in Vps35-deficient cells and cornea.	Water	93-96	VPS35 retromer complex component	Homo sapiens	211-216
26488458-12	2015	Taken together, our data show that when incorporated in a lipid monolayer or after adsorption on the water-air interface, Cytc undergoes conformational transition.	Water	101-106	LOC104968582	Bos taurus	122-126
26135921-13	2016	From SPE, the 50:50 water:ethanol volume fraction of CWAF contained this activity, and LC-MS indicated that major components of COREXIT contribute to PPARgamma transactivation in the CWAF.	Water	20-25	peroxisome proliferator activated receptor gamma	Mus musculus	150-159
28779986-5	2017	It is shown that atypical isotherm features and issues of applying BET theory to the calculation of SBET are linked to the presence of hydrated water and that these depend on the hydration state: being more pronounced for the di-hydrate than the mono-hydrate.	Water	144-149	delta/notch like EGF repeat containing	Homo sapiens	67-70
26302870-2	2016	In this study, to achieve tumor-targeted delivery, styrene-maleic acid-copolymer conjugated ZnPP (SMA-ZnPP) was synthesized via amide bond, which showed good water solubility, having ZnPP loading of 15%.	Water	158-163	survival of motor neuron 1, telomeric	Homo sapiens	98-101
25547287-1	2015	Hydrogen release from the splitting of water by simply using sunlight as the only energy source is an old human dream that could finally become a reality.	Water	39-44	potassium voltage-gated channel interacting protein 3	Homo sapiens	112-117
28438322-6	2017	Movement artefacts were more frequent in set 1 whereas five cases (18.5%) exhibited swap artefacts between silicone and water in set 2.	Water	120-125	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	129-134
26227349-7	2015	Moreover, Morris water maze tasks demonstrated that mice treated with AAV-TRE-CD74 showed improved learning and memory compared to AAV-TRE-GFP control animals.	Water	17-22	CD74 molecule	Homo sapiens	78-82
26646616-4	2016	The surface roughness and water contact angle of PLA films increased by CPT and further increased during storage for 56 d. The printability of the PLA films increased following CPT and remained stable throughout the storage period.	Water	26-31	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	72-75
26646616-9	2016	These results demonstrate the potential of CPT for modifying the stiffness, water contact angle, and chemical structure of PLA films and improving the printability and biodegradability of the films for food packaging.	Water	76-81	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	43-46
26565476-1	2015	By combining molecular dynamics simulations and quantum mechanics calculations, we show the formation of a composite structure composed of embedded water molecules and the COOH matrix on carboxyl-terminated self-assembled monolayers (COOH SAMs) with appropriate packing densities.	Water	148-153	methionine adenosyltransferase 1A	Homo sapiens	239-243
28713956-1	2017	MDG-1, a water-soluble polysaccharide extracted from Ophiopogon japonicus, has been reported to serve a role in antimyocardial ischemia by protecting cardiomyocytes from hypoxia/reoxygenation-induced damage.	Water	9-14	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	0-5
26565476-3	2015	This explains the seeming contradiction on the stability of the surface water on COOH SAMs observed in experiments.	Water	72-77	methionine adenosyltransferase 1A	Homo sapiens	86-90
26565476-4	2015	The existence of the composite structure at appropriate packing densities results in the two-step distribution of contact angles of water droplets on COOH SAMs, around 0  and 35 , which compares favorably to the experimental measurements of contact angles collected from forty research articles over the past 25 years.	Water	132-137	methionine adenosyltransferase 1A	Homo sapiens	155-159
26344240-0	2015	AT1 receptor blockade in the central nucleus of the amygdala attenuates the effects of muscimol on sodium and water intake.	Water	110-115	angiotensin II receptor, type 1a	Rattus norvegicus	0-3
26876677-0	2016	Synthesis and Characterization of Dioctanoyl Glycerate as Water-soluble Trypsin Inhibitor.	Water	58-63	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	72-89
26404667-8	2016	Water treatment was associated with significantly lower odds of B hominis (0 52, 0 34-0 78), E histolytica or E dispar (0 61, 0 38-0 99), G intestinalis (0 63, 0 50-0 80), and Cryptosporidium spp infections (0 83, 0 70-0 98).	Water	0-5	histocompatibility minor 13	Homo sapiens	192-195
28625546-6	2017	Losartan (AT1 antagonist, 100mug) or atropine (muscarinic antagonist, 20 nmol) injected icv abolished the effects on water and 0.3M NaCl of moxonidine combined to either 2M NaCl intragastrically or carbachol icv.	Water	117-122	angiotensin II receptor, type 1a	Rattus norvegicus	10-13
26340743-1	2016	Fat- and nonfat-containing meat gels structurally became coarser and porous by partial substitution of whey protein isolate for myofibrillar protein, creating a weaker texture plus greater cook loss (CL: fat+water) and expressible water (EW).	Water	208-213	FAT atypical cadherin 1	Homo sapiens	0-3
26340743-1	2016	Fat- and nonfat-containing meat gels structurally became coarser and porous by partial substitution of whey protein isolate for myofibrillar protein, creating a weaker texture plus greater cook loss (CL: fat+water) and expressible water (EW).	Water	231-236	FAT atypical cadherin 1	Homo sapiens	0-3
26340743-5	2016	Only when large pores or continuous fissures are structurally present can water be released, allowing liquid fat to also migrate and coalesce.	Water	74-79	FAT atypical cadherin 1	Homo sapiens	109-112
26344240-1	2015	The blockade of the central nucleus of the amygdala (CeA) with the GABAA receptor agonist muscimol significantly reduces hypertonic NaCl and water intake by sodium-depleted rats.	Water	141-146	carcinoembryonic antigen gene family 4	Rattus norvegicus	53-56
26344240-2	2015	In the present study we investigated the effects of previous injection of losartan, an angiotensin II type-1 (AT1) receptor antagonist, into the CeA on 0.3M NaCl and water intake reduced by muscimol bilaterally injected into the same areas in rats submitted to water deprivation-partial rehydration (WD-PR) and in rats treated with the diuretic furosemide (FURO).	Water	166-171	carcinoembryonic antigen gene family 4	Rattus norvegicus	145-148
26344240-4	2015	Bilateral injections of muscimol (0.2 nmol/0.5 mul, n=8 rats/group) into the CeA in WD-PR-treated rats reduced 0.3M NaCl intake and water intake, and pre-treatment of the CeA with losartan (50 mug/0.5 mul) reversed the inhibitory effect of muscimol.	Water	132-137	carcinoembryonic antigen gene family 4	Rattus norvegicus	77-80
28808020-3	2017	By contrast, in epithelial cells from the colon, stomach, and kidney, KCNE3 coassembles with KCNQ1 to form K+ channels that are voltage-independent K+ channels in the physiological voltage range and important for controlling water and salt secretion and absorption.	Water	225-230	potassium voltage-gated channel subfamily E regulatory subunit 3	Homo sapiens	70-75
26427906-3	2015	We report here the presence of a cryptic pocket at the protein-binding interface of eIF4E, which opens transiently during molecular dynamics simulations of the protein in solvent water and is observed to be stable when solvent water is mixed with benzene molecules.	Water	179-184	eukaryotic translation initiation factor 4E	Homo sapiens	84-89
27508381-10	2016	Ozonation of secondary wastewater attained the South African water standards in terms of COD required for wastewater discharge and dissolved organic carbon in drinking water and increased significantly the biodegradability of primary wastewater.	Water	61-66	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	89-92
26427906-3	2015	We report here the presence of a cryptic pocket at the protein-binding interface of eIF4E, which opens transiently during molecular dynamics simulations of the protein in solvent water and is observed to be stable when solvent water is mixed with benzene molecules.	Water	227-232	eukaryotic translation initiation factor 4E	Homo sapiens	84-89
28697599-0	2017	Enhancement of Friction by Water Intercalated between Graphene and Mica.	Water	27-32	MHC class I polypeptide-related sequence A	Homo sapiens	67-71
26642107-5	2015	High bound water content avoids the membrane dehydration, and most optimal (SCP-1.33) membrane exhibited about ~2.5-fold high bound water content in comparison with that of Nafion117 membrane.	Water	11-16	synaptonemal complex protein 1	Homo sapiens	76-81
26642107-5	2015	High bound water content avoids the membrane dehydration, and most optimal (SCP-1.33) membrane exhibited about ~2.5-fold high bound water content in comparison with that of Nafion117 membrane.	Water	132-137	synaptonemal complex protein 1	Homo sapiens	76-81
28697599-7	2017	Density functional theory calculations show that water broadens the spectral range of graphene vibrations-particularly the low-frequency flexural modes-thus providing new excitation channels and also by increasing the overlap with the atomic vibrations of the mica substrate, which facilitates coupling and energy transfer.	Water	49-54	MHC class I polypeptide-related sequence A	Homo sapiens	260-264
26393288-4	2015	Its corresponding coating showed excellent water vapor barrier ability for a typical water-soluble crystal, potassium dihydrogen phosphate (KDP).	Water	43-48	WNK lysine deficient protein kinase 1	Homo sapiens	140-143
26393288-4	2015	Its corresponding coating showed excellent water vapor barrier ability for a typical water-soluble crystal, potassium dihydrogen phosphate (KDP).	Water	85-90	WNK lysine deficient protein kinase 1	Homo sapiens	140-143
28576715-5	2017	DOX and CA4 were co-loaded into the hydrogel, and the release of DOX showed much faster than that of CA4 due to their difference in water solubility.	Water	132-137	carbonic anhydrase 4	Mus musculus	8-11
26487787-1	2015	We report a transport behavior-specifically, rapid retraction movement-of small (~muL) deionized water plugs traveling in series within a small wettable tubular geometry.	Water	97-102	tripartite motif containing 37	Homo sapiens	82-85
26517941-0	2015	Evaluation of the boundary condition influence on PAH concentrations in the water column during the sediment dredging of a port.	Water	76-81	phenylalanine hydroxylase	Homo sapiens	50-53
26517941-3	2015	The results showed relatively low background PAH concentrations in the water column and confirmed the dredging as the primary rising factor of concentrations in the water column, but also showed a complex scenario in which the different environmental and dredging factors forced the concentrations at different levels and moments.	Water	71-76	phenylalanine hydroxylase	Homo sapiens	45-48
26652006-3	2015	To this end, we have developed acoustogenic probes for copper(II)-1 and -2 (APC-1 and APC-2, a water-soluble congener) for the chemoselective visualization of Cu(II), a metal ion which plays a crucial role in chronic neurological disorders such as Alzheimer"s disease.	Water	95-100	APC regulator of WNT signaling pathway 2	Homo sapiens	86-91
28576715-5	2017	DOX and CA4 were co-loaded into the hydrogel, and the release of DOX showed much faster than that of CA4 due to their difference in water solubility.	Water	132-137	carbonic anhydrase 4	Mus musculus	101-104
26555823-4	2015	In particular, the reaction of organic peroxy radicals with the HO2 radical and the H2 O HO2 radical complex represent an autocatalytic source of atmospheric HO2 .	Water	84-88	heme oxygenase 2	Homo sapiens	89-92
26555823-4	2015	In particular, the reaction of organic peroxy radicals with the HO2 radical and the H2 O HO2 radical complex represent an autocatalytic source of atmospheric HO2 .	Water	84-88	heme oxygenase 2	Homo sapiens	89-92
28689291-0	2017	TiO2-SnS2 nanocomposites: solar-active photocatalytic materials for water treatment.	Water	68-73	sodium voltage-gated channel alpha subunit 11	Homo sapiens	5-9
28689291-1	2017	The study is aimed at evaluating TiO2-SnS2 composites as effective solar-active photocatalysts for water treatment.	Water	99-104	sodium voltage-gated channel alpha subunit 11	Homo sapiens	38-42
26862587-1	2016	This data article presents an analysis of structural water molecules in the high affinity interaction between a potent tumor growth inhibiting antibody (fragment), J22.9-xi, and the tumor marker antigen CD269 (B cell maturation antigen, BCMA).	Water	53-58	tumor necrosis factor receptor superfamily, member 17	Mus musculus	210-235
28639422-8	2017	The medaka cntn1b mutants had defective optokinetic response (OKR) adaptation and abnormal rheotaxis (body positioning relative to water flow).	Water	131-136	contactin 1b	Danio rerio	11-17
26862587-1	2016	This data article presents an analysis of structural water molecules in the high affinity interaction between a potent tumor growth inhibiting antibody (fragment), J22.9-xi, and the tumor marker antigen CD269 (B cell maturation antigen, BCMA).	Water	53-58	tumor necrosis factor receptor superfamily, member 17	Mus musculus	237-241
26470817-2	2015	Failures in pHi homeostasis could alter critical cellular functions such as water transport and cell volume.	Water	76-81	glucose-6-phosphate isomerase	Homo sapiens	12-15
28631499-0	2017	The microbial contamination and the presence of beta-lactamase producing Gram-negative bacteria in the water and on the surfaces of public recreation water facilities.	Water	103-108	beta-lactamase	Escherichia coli	48-62
26470817-3	2015	Here, we evaluated whether alterations in syncytiotrophoblast pHi could modify water uptake mediated by aquaporins (AQPs) and the contribution of NHEs to this mechanism.	Water	79-84	glucose-6-phosphate isomerase	Homo sapiens	62-65
28774629-2	2017	A major portion of total organic halogen (TOX), a collective parameter for all halogenated DBPs, formed in ClO2-treated drinking water is still unknown.	Water	129-134	thymocyte selection associated high mobility group box	Homo sapiens	42-45
28506525-7	2017	Further examination of occurrences in these eight contexts led to the characterization of three different Mg2+ binding modes: 1) direct binding via N7 coordination, 2) direct binding via O6 coordination, and 3) binding via hydrogen-bonding interaction with the first-shell water molecules.	Water	273-278	mucin 7, secreted	Homo sapiens	106-109
28594118-3	2017	Notably, the presence of guest ions (K+ ) and molecules (H2 O) can substantially switch thermal expansion of YFe(CN)6 from negative (alphav =-33.67x10-6  K-1 ) to positive (alphav =+42.72x10-6  K-1 )-a range that covers the thermal expansion of most inorganic compounds.	Water	57-61	keratin 1	Homo sapiens	154-157
28594118-3	2017	Notably, the presence of guest ions (K+ ) and molecules (H2 O) can substantially switch thermal expansion of YFe(CN)6 from negative (alphav =-33.67x10-6  K-1 ) to positive (alphav =+42.72x10-6  K-1 )-a range that covers the thermal expansion of most inorganic compounds.	Water	57-61	keratin 1	Homo sapiens	194-197
28561856-7	2017	Finally, we improve upon the physical characterization of La(dpp)3 to include a single crystal X-ray structure, which exhibits an 8-coorindate La3+ centre with two bound water molecules, and a disordered exoclathrate-type hydrogen bonded network.	Water	170-175	dipeptidyl peptidase 3	Homo sapiens	58-66
28437020-1	2017	The activity of the water reduction catalyst [CoIII (L1 )(pyr)2 ]PF6 (1), where (L1 )2- is a bis-amido pyridine ligand and pyr is pyrrolidine, is investigated.	Water	20-25	sperm associated antigen 17	Homo sapiens	65-68
28634368-5	2017	Therefore, the as-prepared PP-AM-HBP-NH2 fibers showed a high adsorption capacity (5.64 mmol/g) for CO2 in the presence of water at 25  C, and the utilization efficiency of alkyl amino groups could reach 88.2%, demonstrating that the hyperbranched structure of adsorbents can greatly promote adsorption capacity and efficiency.	Water	123-128	heme binding protein 1	Homo sapiens	33-36
28618266-4	2017	Permeability increases were limited to small molecules, as expected for the paracellular water and Na+ channel formed by claudin-2.	Water	89-94	claudin 2	Mus musculus	121-130
28618266-7	2017	Chemically induced osmotic diarrhea reduced colitis severity and C. rodentium burden in claudin-2-deficient, but not transgenic, mice, demonstrating that claudin-2-mediated protection is the result of enhanced water efflux.	Water	210-215	claudin 2	Mus musculus	154-163
28572558-1	2017	Pyrroloquinoline quinone (PQQ) is a water-soluble quinone compound first identified as a cofactor of alcohol- and glucose-dehydrogenases (ADH and GDH) in bacteria.	Water	36-41	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	146-149
28943996-3	2017	The GCM simulates basic state changes associated with increasing CO2 that are consistent with results from earlier studies: column water vapor increases at ~7.1% K-1, precipitation also increases but at a lower rate (~3% K-1), and column relative humidity shows little change.	Water	131-136	keratin 1	Homo sapiens	162-165
28295351-13	2017	Importantly, isosmotic cell swelling obtained by parallel activation of the co-expressed water-translocating Na+ /K+ /2Cl- cotransporter promoted TRPV4 activation despite the absence of the substantial osmotic gradients frequently employed for activation.	Water	89-94	transient receptor potential cation channel subfamily V member 4	Homo sapiens	146-151
28492629-1	2017	A new 3D metal-organic framework (MOF), in which 2D layers are interlaced to form a 3D architecture, was synthesized by a reaction of Cu(BF4)2 and 1,3-bis(4-pyridyl)propane (bpp) in a water/1-hexanol solvent system, and the crystal structure of the MOF was successfully solved.	Water	184-189	lysine acetyltransferase 8	Homo sapiens	6-38
28492629-1	2017	A new 3D metal-organic framework (MOF), in which 2D layers are interlaced to form a 3D architecture, was synthesized by a reaction of Cu(BF4)2 and 1,3-bis(4-pyridyl)propane (bpp) in a water/1-hexanol solvent system, and the crystal structure of the MOF was successfully solved.	Water	184-189	lysine acetyltransferase 8	Homo sapiens	34-37
28588500-4	2017	Anoctamin 1 (ANO1, also known as TMEM16A) and Aquaporin 5 (AQP5) play an important role in the transport of ions and water in the submandibular glands (SGs).	Water	117-122	anoctamin 1	Rattus norvegicus	0-11
28588500-4	2017	Anoctamin 1 (ANO1, also known as TMEM16A) and Aquaporin 5 (AQP5) play an important role in the transport of ions and water in the submandibular glands (SGs).	Water	117-122	anoctamin 1	Rattus norvegicus	13-17
28588500-4	2017	Anoctamin 1 (ANO1, also known as TMEM16A) and Aquaporin 5 (AQP5) play an important role in the transport of ions and water in the submandibular glands (SGs).	Water	117-122	anoctamin 1	Rattus norvegicus	33-40
28461473-0	2017	ILDR1 is important for paracellular water transport and urine concentration mechanism.	Water	36-41	immunoglobulin-like domain containing receptor 1	Mus musculus	0-5
28461473-2	2017	Here, we provide evidence that the tricellular tight junction is important for paracellular water permeation and that Ig-like domain containing receptor 1 (ILDR1) regulates its permeability.	Water	92-97	immunoglobulin-like domain containing receptor 1	Mus musculus	156-161
28467818-6	2017	Here we develop surrogate Wnt agonists, water-soluble FZD-LRP5/LRP6 heterodimerizers, with FZD5/FZD8-specific and broadly FZD-reactive binding domains.	Water	40-45	frizzled class receptor 5	Homo sapiens	91-95
28490769-6	2017	Heat stroke cases showed an increase in brain water content, which was found to be positively correlated with MMP9, OCLN, ZO1 and CLDN5 mRNA.	Water	46-51	occludin	Homo sapiens	116-120
28490769-6	2017	Heat stroke cases showed an increase in brain water content, which was found to be positively correlated with MMP9, OCLN, ZO1 and CLDN5 mRNA.	Water	46-51	claudin 5	Homo sapiens	130-135
28361396-3	2017	The photocatalytic performances of the RGO-TiO2 composites were evaluated by the degradation of orange II (AO7) in water under UV light irradiation.	Water	115-120	ring finger protein 25	Homo sapiens	107-110
25585014-9	2015	G-CSF treatment reduced brain water content and neuroinflammation by downregulating IKKbeta, NF-kappaB, TNF-alpha, IL-1beta, and IL-12 and upregulating IL-10, thereby reducing neutrophil infiltration.	Water	30-35	colony stimulating factor 3	Rattus norvegicus	0-5
28406644-6	2017	In H2O, upon visible-light irradiation in the presence of oxygen, no photosubstitution took place, but the amine of complex [1a]PF6 was photooxidized to an imine.	Water	3-6	sperm associated antigen 17	Homo sapiens	128-131
26491313-9	2015	The composite film had higher water absorption than the pure PCL, and increasing the concentration of the HAp increased the water absorption.	Water	124-129	reticulon 3	Homo sapiens	106-109
28088116-8	2017	This method is successfully applied to practical detection of Cr3+ ion in industrial waste water.	Water	91-96	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	62-65
27665014-2	2017	Its unstirred water layer (USWL) at the lumen interface involves membrane associated mucin linearly protruding from underlying microvilli that entangles secretory mucin released from local goblet cells.	Water	14-19	LOC100508689	Homo sapiens	85-90
25330738-7	2015	Importantly, overexpression of miR-30a-5p in the mPFC produced an escalation of alcohol intake and a preference over water.	Water	117-122	microRNA 30a	Homo sapiens	31-38
27665014-2	2017	Its unstirred water layer (USWL) at the lumen interface involves membrane associated mucin linearly protruding from underlying microvilli that entangles secretory mucin released from local goblet cells.	Water	14-19	LOC100508689	Homo sapiens	163-168
28541955-2	2017	Dye removal ability of the modified nanofiber (PVA/DETA/EDA/GA) as a nanoadsorbent from water was studied.	Water	88-93	ectodysplasin A	Homo sapiens	56-62
26308256-5	2015	Under normal operating conditions, the packed column contains about 131 +- 4 muL/m of water phase (around a 5% m/m coating), which is over 25x greater than the capillary column and also affords it a 20-fold larger sample capacity.	Water	86-91	tripartite motif containing 37	Homo sapiens	77-80
23719850-0	2015	Low concentrations of copper in drinking water increase AP-1 binding in the brain.	Water	41-46	jun proto-oncogene	Mus musculus	56-60
28414753-8	2017	Moreover, CCL18 levels in effluent at year 3 of PD were independently associated with a risk of PMF development, adjusted for the classical (water and creatinine) peritoneal transport parameters.	Water	141-146	C-C motif chemokine ligand 18	Homo sapiens	10-15
26499907-10	2015	As an application of CeO2 NPs towards the degradation of water pollutants, we demonstrated that the Ce1-xEuxO2 (0 &lt;=x&lt;= 0.3) NPs can serve as effective photocatalyst materials towards the degradation of the methyl-orange aqueous pollutant dye under UV light irradiation.	Water	57-62	carboxylesterase 1	Homo sapiens	100-103
26400305-8	2015	CD68 and pro-inflammatory cytokine mRNA increased in the kidneys of control (BDL-water) rats.	Water	81-86	Cd68 molecule	Rattus norvegicus	0-4
26348407-1	2015	Many studies have determined that AQP1 plays an important role in edema formation and resolution in various tissues via water transport across the cell membrane.	Water	120-125	aquaporin 1	Mus musculus	34-38
28368432-0	2017	Effect of electrostatic polarization and bridging water on CDK2-ligand binding affinities calculated using a highly efficient interaction entropy method.	Water	50-55	cyclin dependent kinase 2	Homo sapiens	59-63
26348407-4	2015	Under physiological conditions, AQP1-/- mice develop normally; however, in the setting of MI, they exhibit cardioprotective properties, as shown by reduced cardiac infarct size determined via NBT staining, improved cardiac function determined via left ventricular catheter measurements, decreased AQP1-dependent myocardial edema determined via water content assays, and decreased apoptosis determined via TUNEL analysis.	Water	344-349	aquaporin 1	Mus musculus	32-36
26443860-5	2015	Mapped accessibility data revealed deep water penetration through hHv1, suggesting a highly focused electric field, comprising two turns of helix along the fourth transmembrane segment.	Water	40-45	hydrogen voltage gated channel 1	Homo sapiens	66-70
28368432-1	2017	A new highly efficient interaction entropy (IE) method combined with the polarized protein-specific charge (PPC) force field is employed to investigate the interaction mechanism of CDK2-ligand binding and the effect of the bridging water.	Water	232-237	cyclin dependent kinase 2	Homo sapiens	181-185
26358148-2	2015	In the present study, we investigated the importance of the facilitatory mechanisms of the CeA on NaCl and water intake produced by the deactivation of LPBN inhibitory mechanisms.	Water	107-112	carcinoembryonic antigen gene family 4	Rattus norvegicus	91-94
28424593-7	2017	In vivo, combined treatment with Prdx6-iPLA2 activity inhibitor MJ33 showed a greater diminution in neurologic deficits, cerebral infarction, brain water content and inflammatory molecules than Prdx6-siRNA treatment alone.	Water	148-153	peroxiredoxin 6	Rattus norvegicus	33-38
26358148-5	2015	The GABAA agonist muscimol (0.25 nmol/0.2 mul) injected bilaterally into the CeA abolished the effects of moxonidine into the LPBN on 0.3M NaCl (2.8 +- 1.6 ml/2h) and water intake (3.3 +- 2.3 ml/2h).	Water	167-172	carcinoembryonic antigen gene family 4	Rattus norvegicus	77-80
26358148-7	2015	Muscimol (0.5 nmol/0.2 mul) into the CeA also abolished 0.3M NaCl (0.1 +- 0.04 ml/4h) and water intake (0.1 +- 0.02 ml/4h) in euhydrated treated with muscimol into the LPBN.	Water	90-95	carcinoembryonic antigen gene family 4	Rattus norvegicus	37-40
26242895-10	2015	Biofilm production was associated with the presence of esp (P &lt; 0.001) and ace genes (P = 0.021), being higher in infecting (P &lt; 0.001) and water (P 0.005) isolates as compared with colonizing ones.	Water	146-151	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	55-58
26344240-7	2015	These results suggest that the deactivation of CeA facilitatory mechanisms by muscimol injection into the CeA is promoted by endogenous angiotensin II acting on AT1 receptors in the CeA, which prevents rats from ingesting large amounts of hypertonic NaCl and water.	Water	259-264	carcinoembryonic antigen gene family 4	Rattus norvegicus	47-50
26344240-7	2015	These results suggest that the deactivation of CeA facilitatory mechanisms by muscimol injection into the CeA is promoted by endogenous angiotensin II acting on AT1 receptors in the CeA, which prevents rats from ingesting large amounts of hypertonic NaCl and water.	Water	259-264	carcinoembryonic antigen gene family 4	Rattus norvegicus	106-109
26344240-7	2015	These results suggest that the deactivation of CeA facilitatory mechanisms by muscimol injection into the CeA is promoted by endogenous angiotensin II acting on AT1 receptors in the CeA, which prevents rats from ingesting large amounts of hypertonic NaCl and water.	Water	259-264	angiotensin II receptor, type 1a	Rattus norvegicus	161-164
26344240-7	2015	These results suggest that the deactivation of CeA facilitatory mechanisms by muscimol injection into the CeA is promoted by endogenous angiotensin II acting on AT1 receptors in the CeA, which prevents rats from ingesting large amounts of hypertonic NaCl and water.	Water	259-264	carcinoembryonic antigen gene family 4	Rattus norvegicus	106-109
26241578-0	2015	Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury.	Water	0-5	matrix metallopeptidase 9	Mus musculus	14-19
26241578-7	2015	MMP-9 inhibition by a water-soluble thiirane inhibitor is a promising therapy for treatment of TBI.	Water	22-27	matrix metallopeptidase 9	Mus musculus	0-5
26290367-1	2015	Vasopressin (VP) stimulates a signaling cascade that results in phosphorylation and apical membrane accumulation of aquaporin-2 (AQP2), leading to water reabsorption by kidney collecting ducts.	Water	147-152	aquaporin 2	Sus scrofa	116-127
26290367-1	2015	Vasopressin (VP) stimulates a signaling cascade that results in phosphorylation and apical membrane accumulation of aquaporin-2 (AQP2), leading to water reabsorption by kidney collecting ducts.	Water	147-152	aquaporin 2	Sus scrofa	129-133
26177482-9	2015	Our results indicate that ER, GR and PR, were capable of screening for different water quality, i.e., the highest bioactivity was observed in the plant influent, which also contained the highest concentrations of endocrine active chemicals measured by LC-MS/MS.	Water	81-86	progesterone receptor	Homo sapiens	37-39
26280941-1	2015	A lanthanide-functionalized MOF with extremely high water tolerance was developed as a fluorescent probe for hippuric acid (HA) in urine which is considered as the biological indicators of toluene exposure.	Water	52-57	lysine acetyltransferase 8	Homo sapiens	28-31
26033954-1	2015	Water-soluble cyclic beta(2,3)-aminoxy peptides have been successfully prepared and characterized in polar organic solvents and aqueous media.	Water	0-5	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	21-29
26120029-7	2015	The results suggest that water and sodium ingestion in response to hypovolemic/hypotensive stimuli are disturbed in nephrotic rats, and provide evidence that the disordered behaviors reflect disturbances of the peripheral renin-angiotensin-aldosterone system.	Water	25-30	renin	Rattus norvegicus	222-227
26424896-15	2015	Specifically, water influx through AQP4 drives calcium influx via TRPV4 in the glial end foot, which regulates expression of Aqp4 and Kir4.1 genes and facilitates the time course and amplitude of hypotonicity-induced swelling and regulatory volume decrease.	Water	14-19	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	134-140
26245860-4	2015	Compared with NiO, CoO and Fe2O3, the NiO/CoO/Fe2O3 composite exhibits a lower overpotential and a much smaller Tafel slope of 49 mV dec(-1) for water oxidation.	Water	145-150	deleted in esophageal cancer 1	Homo sapiens	133-139
26335828-5	2015	This structure corresponds to an antiferroelectric configuration where the dipole moments of CuOH molecules belonging to adjacent arrays are antiparallel and are arranged in the same way as the water molecules in ice-VIII.	Water	194-199	cytochrome c oxidase subunit 8A	Homo sapiens	217-221
26078194-4	2015	UGT71A15 (a uridine 5"-diphosphate alpha-D-glucose-dependent glucosyltransferase from apple) was used to synthesize resveratrol 3,5-beta-D-diglucoside; this was about 1700-fold more water-soluble than the unglucosylated molecule (~0.18 mM), yet retained most of the antioxidant activity.	Water	182-187	uDP-glycosyltransferase 71A15	Malus domestica	0-8
26331261-6	2015	Interestingly, our data show that the reconfiguration dynamics of CGRP is significantly slower than that of human IAPP in water but not in denaturant, providing experimental evidence for roughness in the energy landscape, or internal friction, in these peptides.	Water	122-127	islet amyloid polypeptide	Homo sapiens	114-118
26270023-1	2015	Lung surfactant protein B (SP-B) is an essential protein found in the surfactant fluid at the air-water interface of the lung.	Water	98-103	surfactant protein B	Homo sapiens	5-25
26270023-1	2015	Lung surfactant protein B (SP-B) is an essential protein found in the surfactant fluid at the air-water interface of the lung.	Water	98-103	surfactant protein B	Homo sapiens	27-31
25681551-6	2015	(2) The mean electrostatic force exerted on the ligand by the water molecules polarized by E(ext) is thought to result from the dielectric polarization (P(protein)) in the region occupied by the protein, where P(protein) is proportional to -E(ext).	Water	62-67	OCA2 melanosomal transmembrane protein	Homo sapiens	153-163
25681551-6	2015	(2) The mean electrostatic force exerted on the ligand by the water molecules polarized by E(ext) is thought to result from the dielectric polarization (P(protein)) in the region occupied by the protein, where P(protein) is proportional to -E(ext).	Water	62-67	OCA2 melanosomal transmembrane protein	Homo sapiens	210-220
25896562-1	2015	The terminal respiratory enzyme cytochrome c oxidase (CcO) reduces molecular oxygen to water, and pumps protons across the inner mitochondrial membrane, or the plasma membrane of bacteria.	Water	87-92	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	32-52
25896562-1	2015	The terminal respiratory enzyme cytochrome c oxidase (CcO) reduces molecular oxygen to water, and pumps protons across the inner mitochondrial membrane, or the plasma membrane of bacteria.	Water	87-92	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	54-57
25896562-4	2015	We have performed classical atomistic molecular dynamics (MD) simulations on a three-subunit CcO, which show the formation of water wires between the polar head groups of lipid molecules bound to subunit III and the proton uptake site Asp91 (Bos taurus enzyme numbering).	Water	126-131	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	93-96
26338870-3	2015	This study investigated the role of the aquaporin (AQP) water channel in the osmotic uptake of water during oogenesis in the silk moth Bombyx mori Linnaeus, 1758.	Water	56-61	aquaporin	Bombyx mori	40-49
26338870-3	2015	This study investigated the role of the aquaporin (AQP) water channel in the osmotic uptake of water during oogenesis in the silk moth Bombyx mori Linnaeus, 1758.	Water	56-61	aquaporin	Bombyx mori	51-54
26338870-3	2015	This study investigated the role of the aquaporin (AQP) water channel in the osmotic uptake of water during oogenesis in the silk moth Bombyx mori Linnaeus, 1758.	Water	95-100	aquaporin	Bombyx mori	40-49
26338870-3	2015	This study investigated the role of the aquaporin (AQP) water channel in the osmotic uptake of water during oogenesis in the silk moth Bombyx mori Linnaeus, 1758.	Water	95-100	aquaporin	Bombyx mori	51-54
26287328-1	2015	BACKGROUND: Water jet-assisted liposuction (WAL) and power-assisted liposuction (PAL) are used for autologous fat grafting.	Water	12-17	FAT atypical cadherin 1	Homo sapiens	110-113
26287328-5	2015	Furthermore, in order to determine particle size, an optically evaluable water-fat emulsion was analysed by macroscopic inspection and light microscopy.	Water	73-78	FAT atypical cadherin 1	Homo sapiens	79-82
25930667-3	2015	Endogenous GC-C agonists - guanylin peptides: guanylin and uroguanylin, by the regulation of water and electrolyte transport, are involved in the maintenance of homeostasis in the intestines and integrity of the intestinal mucosa.	Water	93-98	guanylate cyclase 2C	Homo sapiens	11-15
26197201-3	2015	Computer simulations, expression studies and functional analyses in Aqp1 knockout mice demonstrated the critical role of the water channel aquaporin-1 (AQP1) in water removal during peritoneal dialysis.	Water	125-130	aquaporin 1	Mus musculus	68-72
26197201-3	2015	Computer simulations, expression studies and functional analyses in Aqp1 knockout mice demonstrated the critical role of the water channel aquaporin-1 (AQP1) in water removal during peritoneal dialysis.	Water	125-130	aquaporin 1	Mus musculus	152-156
26197201-3	2015	Computer simulations, expression studies and functional analyses in Aqp1 knockout mice demonstrated the critical role of the water channel aquaporin-1 (AQP1) in water removal during peritoneal dialysis.	Water	161-166	aquaporin 1	Mus musculus	152-156
26139825-7	2015	This expression pattern suggests that reduced water uptake and limited cell wall extension are associated with the closed state of stomata of bam1 mutant plants.	Water	46-51	beta-amylase 1	Arabidopsis thaliana	142-146
26615663-4	2015	Soybean contains Bet v 1-related antigen (Gly m 4), and soy milk often causes the OAS with severe symptoms such as precordial and abdominal burning sensation because soy milk undergoes little denaturation, and this water-soluble liquid is consumed by most people rather quickly.	Water	215-220	SPARC related modular calcium binding 1	Homo sapiens	82-85
26123650-1	2015	BACKGROUNDS: This study aims to estimate the impact of preventing urinary tract infections (UTI), using a strategy of increased water intake, from the payer"s perspective in the French health care system.	Water	128-133	alpha-1-microglobulin/bikunin precursor	Homo sapiens	92-95
26123650-8	2015	With adequate water intake, the model indicates a potential cost savings of $2.288 millions annually, by preventing 27 million UTI episodes.	Water	14-19	alpha-1-microglobulin/bikunin precursor	Homo sapiens	127-130
26983216-5	2015	The results showed that ethyl acetate extract is the active part of Kansui Radix stir-baked with vinegar on the function of expelling water retention with drastic purgative on the cancerous ascites model rats, alleviating the water-electrolyte disorder and body fluid acid-base imbalance, regulating the renin angiotensin aldosterone system.	Water	226-231	renin	Rattus norvegicus	304-309
26160054-3	2015	BNP and ANP, acting through a guanylyl cyclase receptor, increase sodium and water excretion by the kidney, induce vasodilation, reduce blood pressure, counteract the bioactivity of the renin-angiotensin-aldosterone and sympathetic nervous systems and possess anti-hypertrophic and anti-fibrotic properties.	Water	77-82	natriuretic peptide B	Homo sapiens	0-3
28412005-2	2015	In this research, the potential use of an extruded flour-water paste as fat replacer in an oil-in-water emulsion was studied.	Water	57-62	FAT atypical cadherin 1	Homo sapiens	72-75
26396698-2	2015	OBJECTIVES: As urine enters the ureters and renal pelvis during voiding in vesicoureteral reflux (VUR), we hypothesized that change in body water composition before and after voiding may be less different in children with VUR.	Water	140-145	VUR	Homo sapiens	98-101
26396698-2	2015	OBJECTIVES: As urine enters the ureters and renal pelvis during voiding in vesicoureteral reflux (VUR), we hypothesized that change in body water composition before and after voiding may be less different in children with VUR.	Water	140-145	VUR	Homo sapiens	222-225
26026161-4	2015	ApoC-II adsorption to a triacylglycerol/water interface resulted in large increases in surface pressure.	Water	40-45	apolipoprotein C2	Homo sapiens	0-7
26026161-8	2015	We characterized apoC-II at phospholipid/triacylglycerol/water interfaces, which more closely mimic lipoprotein surfaces.	Water	57-62	apolipoprotein C2	Homo sapiens	17-24
26054741-1	2015	Two luminescent probes [Eu.L1-2]+ are reported for the rapid detection of fluoride in water.	Water	86-91	LINE1 retrotransposable element 1	Homo sapiens	27-31
26203226-3	2015	MATERIALS AND METHODS: BMP-2 NPs were prepared using a water-in-oil-in-water double-emulsion solvent evaporation/extraction method.	Water	55-60	bone morphogenetic protein 2	Homo sapiens	23-28
26203226-3	2015	MATERIALS AND METHODS: BMP-2 NPs were prepared using a water-in-oil-in-water double-emulsion solvent evaporation/extraction method.	Water	71-76	bone morphogenetic protein 2	Homo sapiens	23-28
26100876-1	2015	The richness of the phase diagram of water reduces drastically at very high pressures where only two molecular phases, proton-disordered ice VII and proton-ordered ice VIII, are known.	Water	37-42	cytochrome c oxidase subunit 8A	Homo sapiens	168-172
26149818-0	2015	Synthesis of magnetic metal-organic framework (MOF) for efficient removal of organic dyes from water.	Water	95-100	lysine acetyltransferase 8	Homo sapiens	22-51
26149818-1	2015	A novel, simple and efficient strategy for fabricating a magnetic metal-organic framework (MOF) as sorbent to remove organic compounds from simulated water samples is presented and tested for removal of methylene blue (MB) as an example.	Water	150-155	lysine acetyltransferase 8	Homo sapiens	66-95
26373083-1	2015	Silver sulfide (Ag2S) near-infrared quantum dots have been synthesized by one pot process and the water solubility of the quantum dots was enhanced by ligand exchange.	Water	98-103	angiotensin II receptor type 1	Homo sapiens	16-20
25947374-5	2015	Crystal structures of hpol eta mutant ternary complexes reveal that polarized water molecules can mimic and partially compensate for the missing side chains of Arg-61 and Gln-38 in the Q38A/R61A mutant.	Water	78-83	endothelin receptor type A	Homo sapiens	27-30
25839832-5	2015	The MDC achieved the highest salt removal rate of 1.2 g L(-1) d(-1) with an initial salinity of 5.9 g L(-1) and a hydraulic retention time (HRT) of 0.8 d. The desalinated brackish water could meet the irrigation standard of both salinity (450 mg L(-1) TDS) and the concentrations of major ionic species, given a sufficient HRT.	Water	180-185	C-C motif chemokine ligand 22	Homo sapiens	4-7
25839832-7	2015	A previously developed MDC model was improved for brackish water desalination, and could well predict salinity variation and the concentrations of individual ions.	Water	59-64	C-C motif chemokine ligand 22	Homo sapiens	23-26
25988324-0	2015	Can a single water molecule really affect the HO2 + NO2 hydrogen abstraction reaction under tropospheric conditions?	Water	13-18	heme oxygenase 2	Homo sapiens	46-49
25988324-1	2015	The effect of a single water molecule on the HO2 + NO2 hydrogen abstraction reaction has been investigated by employing B3LYP and CCSD(T) theoretical approaches with the aug-cc-pVTZ basis set.	Water	23-28	heme oxygenase 2	Homo sapiens	45-48
25988324-2	2015	The reaction without water has three types of reaction channels on both singlet and triplet potential energy surfaces, depending on how the HO2 radical approaches NO2.	Water	21-26	heme oxygenase 2	Homo sapiens	140-143
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Water	9-14	heme oxygenase 2	Homo sapiens	118-121
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Water	9-14	heme oxygenase 2	Homo sapiens	129-132
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Water	9-14	heme oxygenase 2	Homo sapiens	149-164
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Water	112-115	heme oxygenase 2	Homo sapiens	118-121
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Water	112-115	heme oxygenase 2	Homo sapiens	129-132
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Water	112-115	heme oxygenase 2	Homo sapiens	149-164
25996798-0	2015	Effects of Water on Solvation Layers of Imidazolium-Type Room Temperature Ionic Liquids on Silica and Mica.	Water	11-16	MHC class I polypeptide-related sequence A	Homo sapiens	102-106
25947336-1	2015	A water-stable copper metal-organic framework (MOF), {[Cu2(HL)2(mu2-OH)2(H2O)5] H2O}n (1, H2L = 2,5-dicarboxylic acid-3,4-ethylene dioxythiophene), was applied for the electrochemical detection of ascorbic acid (AA) without further post-modification.	Water	2-7	lysine acetyltransferase 8	Homo sapiens	22-52
26212084-3	2015	Claudin-2 is a tight junction protein that mediates paracellular water transport in intestinal epithelia, rendering them "leaky".	Water	65-70	claudin 2	Mus musculus	0-9
26019178-7	2015	In addition, our further calculations show that, the PMF between A-RNAs could become strongly attractive either at very high [Co-Hex] or when the bottom of deep major groove is fixed with a layer of water.	Water	199-204	hematopoietically expressed homeobox	Homo sapiens	129-132
26067160-0	2015	Droplet-based microreactor for synthesis of water-soluble Ag2S quantum dots.	Water	44-49	angiotensin II receptor type 1	Homo sapiens	58-62
26067160-1	2015	A droplet-based microreactor was used for synthesis of water-soluble Ag2S quantum dots (QDs).	Water	55-60	angiotensin II receptor type 1	Homo sapiens	69-73
28421085-12	2017	This study demonstrated that expression of AtSHN1, can increase surface wax load and reduce the post-harvest water loss in mulberry.	Water	109-114	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	43-49
26153706-1	2015	The hydrophobic surfactant proteins SP-B and SP-C greatly accelerate the adsorption of vesicles containing the surfactant lipids to form a film that lowers the surface tension of the air/water interface in the lungs.	Water	187-192	surfactant protein B	Homo sapiens	36-40
25839973-0	2015	MOF-derived magnetic carbonaceous nanocomposite as a heterogeneous catalyst to activate oxone for decolorization of Rhodamine B in water.	Water	131-136	lysine acetyltransferase 8	Homo sapiens	0-3
26082696-9	2015	In the novel object recognition and water-finding tests, MGL KO mice exhibited enhanced memory acquisition.	Water	36-41	monoglyceride lipase	Mus musculus	57-60
28487819-7	2017	The effectiveness of Au-DNA nanocomposites was further verified by comparing the known concentration (50-120 ppm) of Mg2+ ions in synthetic tap water and a real life sample of Gelusil (300-360 ppm Mg2+), a widely used antacid medicine.	Water	144-149	mucin 7, secreted	Homo sapiens	117-120
25931204-2	2015	Aldosterone and vasopressin modulate ion transporters and channels crucial in sodium (Na) and water reabsorption such as the epithelium Na channel and the renal thiazide-sensitive NaCl cotransporter (NCC).	Water	94-99	solute carrier family 12 member 3	Homo sapiens	180-198
25931204-2	2015	Aldosterone and vasopressin modulate ion transporters and channels crucial in sodium (Na) and water reabsorption such as the epithelium Na channel and the renal thiazide-sensitive NaCl cotransporter (NCC).	Water	94-99	solute carrier family 12 member 3	Homo sapiens	200-203
26122204-0	2015	Water extract of brewers" rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/beta-catenin downstream signaling pathway in brewers" rice-treated rats with azoxymethane-induced colon carcinogenesis.	Water	0-5	caspase 8	Homo sapiens	114-123
26035438-10	2015	The nearby exchangeable proton in both the no-substrate and Arg-containing nNOS samples is located outside the H-bonding range and, on the basis of the obtained structural constraints, can belong to the active site water (or OH).	Water	215-220	nitric oxide synthase 1	Homo sapiens	75-79
28328214-4	2017	This superior-water-stability MOF shows striking proton conductivity with sigma = 7.58 x 10-3 S cm-1 at 315 K and 99% relative humidity.	Water	14-19	lysine acetyltransferase 8	Homo sapiens	30-33
25682067-6	2015	The predictions were validated and tested by comparison to more than 1500 crystallographic water positions in 20 hydrated protein molecules including enzymes of biomedical importance such as cyclin-dependent kinase 2.	Water	91-96	cyclin dependent kinase 2	Homo sapiens	191-216
26221267-7	2015	In sharp contrast to the C:M phase, water phase was mainly responsible for the production of IL-37.	Water	36-41	interleukin 37	Homo sapiens	93-98
26221267-8	2015	Since ManLAM is the major component of water phase, we found that ManLAM induced IL-37 mRNA and protein expression in a time and dose-dependent manner, while this activity was almost totally abolished by the ERK1/2 (U0126) and p38 (SB203580) inhibitor.	Water	39-44	interleukin 37	Homo sapiens	81-86
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Water	191-196	heme oxygenase 2	Homo sapiens	118-121
28452574-0	2017	Water transport through the intestinal epithelial barrier under different osmotic conditions is dependent on LI-cadherin trans-interaction.	Water	0-5	cadherin 17	Homo sapiens	109-120
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Water	191-196	heme oxygenase 2	Homo sapiens	129-132
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Water	191-196	heme oxygenase 2	Homo sapiens	149-164
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Water	31-34	heme oxygenase 2	Homo sapiens	37-40
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Water	31-34	heme oxygenase 2	Homo sapiens	182-185
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Water	31-34	heme oxygenase 2	Homo sapiens	182-185
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Water	188-191	heme oxygenase 2	Homo sapiens	37-40
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Water	188-191	heme oxygenase 2	Homo sapiens	182-185
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Water	188-191	heme oxygenase 2	Homo sapiens	182-185
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Water	188-191	heme oxygenase 2	Homo sapiens	37-40
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Water	188-191	heme oxygenase 2	Homo sapiens	182-185
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Water	188-191	heme oxygenase 2	Homo sapiens	182-185
25659484-0	2015	Aquaporin-1 facilitates pressure-driven water flow across the aortic endothelium.	Water	40-45	aquaporin 1	Rattus norvegicus	0-11
25659484-1	2015	Aquaporin-1, a ubiquitous water channel membrane protein, is a major contributor to cell membrane osmotic water permeability.	Water	26-31	aquaporin 1	Rattus norvegicus	0-11
25659484-6	2015	Impaired aquaporin-1 endothelia consistently showed reduced engineering flow metrics (transendothelial water flux and hydraulic conductivity).	Water	103-108	aquaporin 1	Rattus norvegicus	9-20
25659484-12	2015	In conclusion, aquaporin-1 significantly contributes to hydrostatic pressure-driven water transport across aortic endothelial monolayers, both in culture and in whole rat aortas.	Water	84-89	aquaporin 1	Rattus norvegicus	15-26
28452574-3	2017	It has been hypothesized that LI-cadherin is important in this process by keeping the intercellular cleft narrow facilitating the buildup of an osmotic gradient allowing water reabsorption.	Water	170-175	cadherin 17	Homo sapiens	30-41
26067490-8	2015	RESULTS: The Lrrk2 (-/-) mice developed lower levels of EAU, DTH responses and cytokine production by lymphocytes than did their WT controls.	Water	56-59	leucine-rich repeat kinase 2	Mus musculus	13-18
28452574-7	2017	This inhibitory peptide was used to measure LI-cadherin dependency of water transport through a monolayer of epithelial CACO2 cells under various osmotic conditions.	Water	70-75	cadherin 17	Homo sapiens	44-55
28452574-8	2017	If LI-cadherin trans-interaction was inhibited by use of the peptide, water transport from the luminal to the basolateral side was impaired and even reversed in the case of hypertonic conditions whereas no effect could be observed at isotonic conditions.	Water	70-75	cadherin 17	Homo sapiens	3-14
27932501-10	2017	These findings show, for the first time, that SVCT-1 and SVCT-2 are differentially expressed along the intestinal tract and that this pattern of expression is, at least in part, mediated via transcriptional/epigenetic mechanisms.NEW &amp; NOTEWORTHY Our findings show, for the first time, that transporters of the water-soluble vitamin ascorbic acid (i.e., the vitamin C transporters SVCT-1 and SVCT-2) are differentially expressed along the length of the intestinal tract and that the pattern of expression is mediated, at least in part, by transcriptional and epigenetic mechanism(s) affecting both Slc23a1 and Slc23a2 genes.	Water	314-319	solute carrier family 23 member 2	Homo sapiens	57-63
26053757-1	2015	The aim of this study was to evaluate whether water soluble compounds present in aqueous extracts from seven Mediterranean demosponges exert biological activity towards matrix metalloproteinases (MMPs), which represent important pathogenic factors of human diseases.	Water	46-51	matrix metallopeptidase 2	Rattus norvegicus	196-200
26053757-3	2015	Our results demonstrated that the studied extracts contain water soluble compounds able to inhibit MMP-2 and MMP-9 activity and expression.	Water	59-64	matrix metallopeptidase 2	Rattus norvegicus	99-104
26053757-6	2015	Taken together, our results indicate that the aqueous extracts from the selected Mediterranean demosponges possess a variety of water-soluble bioactive compounds, which are able to inhibit MMPs at different levels.	Water	128-133	matrix metallopeptidase 2	Rattus norvegicus	189-193
25985258-1	2015	The water-soluble cationic nickel(II) complex of meso-tetrakis(4-N-methylpyridyl)porphyrin (1) can electrocatalyze water oxidation to O2 in neutral aqueous solution (pH 7.0) with the onset of the catalytic wave appearing at ~1.0 V (vs NHE).	Water	4-9	solute carrier family 9 member C1	Homo sapiens	235-238
25985258-1	2015	The water-soluble cationic nickel(II) complex of meso-tetrakis(4-N-methylpyridyl)porphyrin (1) can electrocatalyze water oxidation to O2 in neutral aqueous solution (pH 7.0) with the onset of the catalytic wave appearing at ~1.0 V (vs NHE).	Water	115-120	solute carrier family 9 member C1	Homo sapiens	235-238
26221479-5	2015	Furthermore, the water extract, but not the ethanol extract, of the GJ dose-dependently inhibited LPS-induced JNK2/1 and slightly p38 mitogen-activated protein kinases (MAPK), and cyclooxygenase-2 (COX-2) expression in BV-2 cells.	Water	17-22	prostaglandin-endoperoxide synthase 2	Mus musculus	180-196
26221479-5	2015	Furthermore, the water extract, but not the ethanol extract, of the GJ dose-dependently inhibited LPS-induced JNK2/1 and slightly p38 mitogen-activated protein kinases (MAPK), and cyclooxygenase-2 (COX-2) expression in BV-2 cells.	Water	17-22	prostaglandin-endoperoxide synthase 2	Mus musculus	198-203
26042980-0	2015	Extraction, characterization and application of malva nut gum in water treatment.	Water	65-70	NUT midline carcinoma family member 1	Homo sapiens	54-57
26042980-3	2015	In this study, malva nut gum (MNG), a new plant-based flocculant, and its composite with Fe in water treatment using single mode mixing are demonstrated.	Water	95-100	NUT midline carcinoma family member 1	Homo sapiens	21-24
26030904-0	2015	Multidrug-Resistant and Extended Spectrum Beta-Lactamase-Producing Escherichia coli in Dutch Surface Water and Wastewater.	Water	101-106	beta-lactamase	Escherichia coli	42-56
25820867-1	2015	The free energy profiles for the chemical reaction of the guanosine triphosphate hydrolysis GTP + H2O   GDP + Pi by Ras-GAP for the wild-type and G13V mutated Ras were computed by using molecular dynamics protocols with the QM(ab initio)/MM potentials.	Water	98-101	RAS p21 protein activator 1	Homo sapiens	116-123
25961720-3	2015	OBJECTIVES: One important example of a standard in humanitarian aid in a disaster setting is "water quantity."	Water	94-99	activation induced cytidine deaminase	Homo sapiens	64-67
25667219-6	2015	To validate these findings, we show that both zebrafish Aqp0a and -0b are functional water channels with respective pH sensitivities toward alkaline or acid pH ranges and that an N-terminal allelic variant (Ser(19)) of Aqp0b exists that abolishes water transport in Xenopus laevis oocytes.	Water	85-90	major intrinsic protein of lens fiber a	Danio rerio	56-61
25865253-0	2015	Hydration and Hydrogen Bond Network of Water during the Coil-to-Globule Transition in Poly(N-isopropylacrylamide) Aqueous Solution at Cloud Point Temperature.	Water	39-44	coilin	Homo sapiens	56-60
25865253-3	2015	Though water plays an important role in this coil-to-globule transition of P-NIPAAm, the behavior of water molecules and the associated hydrogen-bond (HB) network of the surrounding bulk water are still veiled in uncertainty.	Water	7-12	coilin	Homo sapiens	45-49
25865253-4	2015	In this study, we elucidate changes in the hydration state and the dynamical structure of the water HB network of P-NIPAAm aqueous solutions during the coil-to-globule transition by analyzing the complex dielectric constant in the terahertz region (0.25-12 THz), where bulk water reorientations and intermolecular vibrations of water can be selectively probed.	Water	94-99	coilin	Homo sapiens	152-156
25865253-7	2015	The HB network of bulk water becomes more structured as the coil-to-globule phase transition takes place, via decreases in non-HB water and reduction in the orderliness of the tetrahedral HB architecture.	Water	23-28	coilin	Homo sapiens	60-64
25865253-7	2015	The HB network of bulk water becomes more structured as the coil-to-globule phase transition takes place, via decreases in non-HB water and reduction in the orderliness of the tetrahedral HB architecture.	Water	130-135	coilin	Homo sapiens	60-64
25865253-8	2015	Together these results indicate that the coil-to-globule transition is associated with a shift to hydrophobic-dominated interactions that drive thermoresponsive structural changes in the surrounding water molecules.	Water	199-204	coilin	Homo sapiens	41-45
25799264-6	2015	Finally, we obtained water-soluble naphthoflavone (11f) which could obviously eliminate the docetaxel-resistance caused by the enhanced expression of CYP1B1 in MCF-7/1B1 cells.	Water	21-26	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	150-156
25825923-4	2015	The subsequent RE-1,4-NDC-fcu-MOF structural features, contracted windows/pores and high concentration of open metal sites combined with exceptional hydrothermal and chemical stabilities, yielded notable gas/solvent separation properties, driven mostly by adsorption kinetics as exemplified in this work for n-butane/methane, butanol/methanol, and butanol/water pair systems.	Water	356-361	lysine acetyltransferase 8	Homo sapiens	30-33
25858030-11	2015	Pharmacological blockade of the AT1 receptor with losartan prior to RNS abolished both the functional and the molecular responses, suggesting that intrarenal Ang II acting via the AT1 receptor is a major factor for NHE3-mediated sodium and water reabsorption induced by RNS.	Water	240-245	angiotensin II receptor type 1	Homo sapiens	32-35
25858030-11	2015	Pharmacological blockade of the AT1 receptor with losartan prior to RNS abolished both the functional and the molecular responses, suggesting that intrarenal Ang II acting via the AT1 receptor is a major factor for NHE3-mediated sodium and water reabsorption induced by RNS.	Water	240-245	angiotensin II receptor type 1	Homo sapiens	180-183
25807267-7	2015	During MD, NTSR1-GW5 becomes more hydrated compared to wild type NTSR1, with tight hydrogen bonded water clusters within the transmembrane core of the receptor, thus providing evidence that water plays an important role in improving helical packing in the thermostable mutant.	Water	99-104	neurotensin receptor 1	Homo sapiens	11-16
25807267-7	2015	During MD, NTSR1-GW5 becomes more hydrated compared to wild type NTSR1, with tight hydrogen bonded water clusters within the transmembrane core of the receptor, thus providing evidence that water plays an important role in improving helical packing in the thermostable mutant.	Water	190-195	neurotensin receptor 1	Homo sapiens	11-16
25573755-1	2015	Water channel aquaporin-1 (AQP1) is expressed at epithelial cell plasma membranes in renal proximal tubules and thin descending limb of Henle.	Water	0-5	aquaporin 1	Mus musculus	14-25
25573755-1	2015	Water channel aquaporin-1 (AQP1) is expressed at epithelial cell plasma membranes in renal proximal tubules and thin descending limb of Henle.	Water	0-5	aquaporin 1	Mus musculus	27-31
25843576-4	2015	The present research is the first to investigate the frictional behavior of a typical intact vertebrate mucin (loach skin mucin), which can recover the gel structure of mucus via hydrophobic association under physiological conditions (5-10 mg/mL loach skin mucin dissolved in water).	Water	276-281	LOC100508689	Homo sapiens	104-109
25843576-4	2015	The present research is the first to investigate the frictional behavior of a typical intact vertebrate mucin (loach skin mucin), which can recover the gel structure of mucus via hydrophobic association under physiological conditions (5-10 mg/mL loach skin mucin dissolved in water).	Water	276-281	LOC100508689	Homo sapiens	122-127
25843576-4	2015	The present research is the first to investigate the frictional behavior of a typical intact vertebrate mucin (loach skin mucin), which can recover the gel structure of mucus via hydrophobic association under physiological conditions (5-10 mg/mL loach skin mucin dissolved in water).	Water	276-281	LOC100508689	Homo sapiens	122-127
25843576-6	2015	Up to 10 mg/mL loach skin mucin dissolved in water led to a 10-fold reduction in boundary friction of the two substrates.	Water	45-50	LOC100508689	Homo sapiens	26-31
26685501-7	2015	CONCLUSION: The increase in HR and SBP in the luteal phase could be because increased water and salt retention due to the ovarian steroids.	Water	86-91	selenium binding protein 1	Homo sapiens	35-38
26353540-3	2015	It is found that at the same temperature the predicted thermal conductivity of PEM increases with the water content, and at the same water content the predicted thermal conductivity decreases with the temperature.	Water	102-107	mucin 1, cell surface associated	Homo sapiens	79-82
26353540-3	2015	It is found that at the same temperature the predicted thermal conductivity of PEM increases with the water content, and at the same water content the predicted thermal conductivity decreases with the temperature.	Water	133-138	mucin 1, cell surface associated	Homo sapiens	79-82
26353540-4	2015	So both the water content and temperature are important factors affecting thermal conductivities of PEM.	Water	12-17	mucin 1, cell surface associated	Homo sapiens	100-103
25649854-0	2015	Potential ghrelin-mediated benefits and risks of hydrogen water.	Water	58-63	ghrelin	Mus musculus	10-17
24939700-3	2015	Exposure of larvae to water enriched with NaCl (1 mM NaCl) caused a pronounced reduction in Na(+) uptake which was prevented by pharmacological inhibition of cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), two key enzymes involved in the endogenous synthesis of H2S.	Water	22-27	cystathionine beta-synthase a	Danio rerio	158-185
25662390-3	2015	It was suggested that the positions of water molecules in Gal-3 ligand-binding site could be replaced by appropriate chemical groups of ideal inhibitors.	Water	39-44	galectin 3	Homo sapiens	58-63
25662390-4	2015	However, the reported structures of Gal-3 carbohydrate recognition domain (CRD) complexed with lactose showed that the number of water molecules are different and the water positions are inconsistent in the ligand-binding site.	Water	129-134	galectin 3	Homo sapiens	36-41
25662390-4	2015	However, the reported structures of Gal-3 carbohydrate recognition domain (CRD) complexed with lactose showed that the number of water molecules are different and the water positions are inconsistent in the ligand-binding site.	Water	167-172	galectin 3	Homo sapiens	36-41
25662390-5	2015	This study reported four high-resolution (1.24-1.19 A) structures of Gal-3 CRD complexed with lactose, and accurately located 12 conserved water molecules in the water network of Gal-3 CRD ligand-binding site by merging these structures.	Water	139-144	galectin 3	Homo sapiens	69-74
25662390-5	2015	This study reported four high-resolution (1.24-1.19 A) structures of Gal-3 CRD complexed with lactose, and accurately located 12 conserved water molecules in the water network of Gal-3 CRD ligand-binding site by merging these structures.	Water	139-144	galectin 3	Homo sapiens	179-184
25662390-5	2015	This study reported four high-resolution (1.24-1.19 A) structures of Gal-3 CRD complexed with lactose, and accurately located 12 conserved water molecules in the water network of Gal-3 CRD ligand-binding site by merging these structures.	Water	162-167	galectin 3	Homo sapiens	69-74
25662390-5	2015	This study reported four high-resolution (1.24-1.19 A) structures of Gal-3 CRD complexed with lactose, and accurately located 12 conserved water molecules in the water network of Gal-3 CRD ligand-binding site by merging these structures.	Water	162-167	galectin 3	Homo sapiens	179-184
25662390-6	2015	These water molecules either directly stabilize the binding of Gal-3 CRD and lactose, or hold the former water molecules at the right place.	Water	6-11	galectin 3	Homo sapiens	63-68
25662390-6	2015	These water molecules either directly stabilize the binding of Gal-3 CRD and lactose, or hold the former water molecules at the right place.	Water	105-110	galectin 3	Homo sapiens	63-68
25527541-6	2015	Cytoplasmic expression of Agp (in E. coli Origami B) gave a functional enzyme preparation (kcat for phosphoryl transfer from alphaGlc 1-P to water, 40 s(-1)) that was shown by mass spectrometry to exhibit no free cysteines and the native intramolecular disulfide bond between Cys(189) and Cys(195).	Water	141-146	glucose-1-phosphatase precursor	Escherichia coli	26-29
25527541-9	2015	By examining phosphoryl transfer from alphaGlc 1-P to an acceptor substrate other than water (d-fructose or d-glucose), we discovered that Agp exhibited pronounced synthetic activity, unlike Had13, which utilized alphaGlc 1-P mainly for phosphoryl transfer to water.	Water	260-265	glucose-1-phosphatase precursor	Escherichia coli	139-142
24888328-1	2015	Water-soluble CdS quantum dots (QDs) were prepared using mercaptoacetic acid (TGA) as the stabilizer in an aqueous system.	Water	0-5	T-box transcription factor 1	Homo sapiens	78-81
25747587-3	2015	Since adenylyl cyclase 3 (AC3) is expressed throughout nephron, we investigated its role in the physiologic regulation of renal Na(+) and water transport.	Water	138-143	adenylate cyclase 3	Mus musculus	6-24
25747587-3	2015	Since adenylyl cyclase 3 (AC3) is expressed throughout nephron, we investigated its role in the physiologic regulation of renal Na(+) and water transport.	Water	138-143	adenylate cyclase 3	Mus musculus	26-29
25646717-5	2015	On the basis of ~20 mus REMD simulations started from a random coil conformation of the peptide placed in water, we find that unfolded h(r)IAPP(1-19) can insert into the bilayers and the membrane-bound peptide stays mainly at the lipid head-tail interface.	Water	106-111	islet amyloid polypeptide	Homo sapiens	139-143
25460687-1	2015	Water-dispersible CaF2 and Yb(3+)/Er(3+) codoped CaF2 (CaF2:Yb(3+)/Er(3+)) nanocrystals with different sizes and different Yb(3+) and Er(3+) dopant concentrations were synthesized using ionic liquid 1-n-butyl-3-methyl imidazolium tetrafluoroborate as a fluorine source by the rapid microwave-assisted solvothermal method.	Water	0-5	CCR4-NOT transcription complex subunit 8	Homo sapiens	18-22
25460687-1	2015	Water-dispersible CaF2 and Yb(3+)/Er(3+) codoped CaF2 (CaF2:Yb(3+)/Er(3+)) nanocrystals with different sizes and different Yb(3+) and Er(3+) dopant concentrations were synthesized using ionic liquid 1-n-butyl-3-methyl imidazolium tetrafluoroborate as a fluorine source by the rapid microwave-assisted solvothermal method.	Water	0-5	CCR4-NOT transcription complex subunit 8	Homo sapiens	49-53
25460687-1	2015	Water-dispersible CaF2 and Yb(3+)/Er(3+) codoped CaF2 (CaF2:Yb(3+)/Er(3+)) nanocrystals with different sizes and different Yb(3+) and Er(3+) dopant concentrations were synthesized using ionic liquid 1-n-butyl-3-methyl imidazolium tetrafluoroborate as a fluorine source by the rapid microwave-assisted solvothermal method.	Water	0-5	CCR4-NOT transcription complex subunit 8	Homo sapiens	49-53
25481447-2	2015	Topical application of CsA has the potential to overcome this hurdle; however, its use is limited by poor water solubility and low permeability.	Water	106-111	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	23-26
25569307-1	2015	Gel-like coacervates that adhere to both hydrophilic and hydrophobic substrates under water have recently been prepared by ionically cross-linking poly(allylamine) (PAH) with pyrophosphate (PPi) and tripolyphosphate (TPP).	Water	86-91	phenylalanine hydroxylase	Homo sapiens	165-168
25542578-4	2015	Then, [NH4][PF6] was added into the extract to form a water-insoluble ionic liquid [C4MIM][PF6] via a simple metathesis reaction, and the analytes were enriched into the ionic liquid phase.	Water	54-59	sperm associated antigen 17	Homo sapiens	12-15
25542578-4	2015	Then, [NH4][PF6] was added into the extract to form a water-insoluble ionic liquid [C4MIM][PF6] via a simple metathesis reaction, and the analytes were enriched into the ionic liquid phase.	Water	54-59	sperm associated antigen 17	Homo sapiens	91-94
25367751-7	2015	Thus, we demonstrate that IL-18 and caspase-1/11 are components of the response to immunization with the TLR4 agonist/squalene oil-in-water based adjuvant, GLA-SE, providing implications for other adjuvants that combine oils with TLR agonists.	Water	134-139	interleukin 18	Mus musculus	26-31
25367751-7	2015	Thus, we demonstrate that IL-18 and caspase-1/11 are components of the response to immunization with the TLR4 agonist/squalene oil-in-water based adjuvant, GLA-SE, providing implications for other adjuvants that combine oils with TLR agonists.	Water	134-139	caspase 1	Mus musculus	36-45
24666302-4	2015	Most likely, the compounds can displace the zinc-bound water molecule of hCA XII to form a direct interaction with the Zn(2+) ion.	Water	55-60	carbonic anhydrase 12	Homo sapiens	73-80
25790516-4	2015	The emissions inventory revealed that PAH emissions to water were almost entirely attributable to the cokemaking process, with emissions factors ranging from 20 to 55 mg/tonne of coke.	Water	55-60	phenylalanine hydroxylase	Homo sapiens	38-41
25625279-4	2015	Differential scanning calorimetry tests testified that the insoluble Mg2/Al-Ac- LDH evidently decreased the freeze point (FP) of water to -10.68 C. X-ray photoelectron spectroscopy analyses confirmed that the Ac- were strongly confined by the metal layers of LDHs.	Water	129-134	mucin 7, secreted	Homo sapiens	69-72
28061371-7	2017	Multivariable Cox-proportional hazards regression with Efron approximation was employed to evaluate TTP as a function of drinking water arsenic concentrations among planned pregnancies, adjusted for covariates.	Water	130-135	ZFP36 ring finger protein	Homo sapiens	100-103
25340313-0	2015	Combined quantum mechanics/molecular mechanics (QM/MM) simulations for protein-ligand complexes: free energies of binding of water molecules in influenza neuraminidase.	Water	125-130	neuraminidase 1	Homo sapiens	154-167
25340313-2	2015	Here, we apply QM/MM Monte Carlo simulations to investigate binding of water molecules to influenza neuraminidase.	Water	71-76	neuraminidase 1	Homo sapiens	100-113
27102941-3	2017	Stomach ghrelin mRNA was significantly higher at day 2 of water deprivation but then returned to the same levels as water-replete (day 0) mice for the duration of the experiment.	Water	58-63	ghrelin	Mus musculus	8-15
25251268-3	2015	A postulated typical stable water structure characterizes consistent patterns in vertical profiles of Chl, phytoplankton biomass, nutrients, and light across a trophic gradient structured by the vertical flux of nutrients and characterized by the average daily irradiance at the nutricline.	Water	28-33	chordin like 1	Homo sapiens	102-105
27102941-7	2017	In the hypothalamus, water deprivation caused a significant up-regulation in both ghrelin and neuropeptide Y mRNA expression, respectively.	Water	21-26	ghrelin	Mus musculus	82-89
28166210-4	2017	Tpx2 further activates AurA by stabilizing a water-mediated allosteric network that links the C-helix to the active site through an unusual polar residue in the regulatory spine.	Water	45-50	aurora kinase A	Homo sapiens	23-27
28166210-5	2017	The polar spine residue and water network of AurA are essential for phosphorylation-driven activation, but an alternative form of the water network found in related kinases can support Tpx2-driven activation, suggesting that variations in the water-mediated hydrogen bond network mediate regulatory diversification in protein kinases.	Water	28-33	aurora kinase A	Homo sapiens	45-49
28166210-5	2017	The polar spine residue and water network of AurA are essential for phosphorylation-driven activation, but an alternative form of the water network found in related kinases can support Tpx2-driven activation, suggesting that variations in the water-mediated hydrogen bond network mediate regulatory diversification in protein kinases.	Water	134-139	aurora kinase A	Homo sapiens	45-49
28166210-5	2017	The polar spine residue and water network of AurA are essential for phosphorylation-driven activation, but an alternative form of the water network found in related kinases can support Tpx2-driven activation, suggesting that variations in the water-mediated hydrogen bond network mediate regulatory diversification in protein kinases.	Water	134-139	aurora kinase A	Homo sapiens	45-49
28190227-6	2017	Water-soluble CoQ10 prevented mitochondrial dynamic imbalance by reducing Drp1 and Fis1 protein expression to pre-rotenone levels, as well as reducing rotenone treatment-associated mitochondrial fragmentation.	Water	0-5	fission, mitochondrial 1	Mus musculus	83-87
28241728-0	2017	AMPK/alpha-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs.	Water	51-56	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	0-4
25745578-7	2015	Rural background, inadequate water intake, and unsatisfactory toilet habits were found to be strong predictors of UTI.	Water	29-34	alpha-1-microglobulin/bikunin precursor	Homo sapiens	114-117
26579544-8	2015	The results showed that T-1 can be used as a lysosomal tracker with high stability and water solubility within pHs of 4-6, while T-2 and T-3 can be used as probes for cell cytoplasm.	Water	87-92	interleukin 1 receptor like 1	Homo sapiens	24-27
27171126-9	2015	The addition of the c-Met inhibitor crizotinib to the water in which the larvae were kept reduced the migration and proliferation of UM cells expressing c-Met.	Water	54-59	MET proto-oncogene, receptor tyrosine kinase	Danio rerio	20-25
27171126-9	2015	The addition of the c-Met inhibitor crizotinib to the water in which the larvae were kept reduced the migration and proliferation of UM cells expressing c-Met.	Water	54-59	MET proto-oncogene, receptor tyrosine kinase	Danio rerio	153-158
25666608-10	2015	In x-ray structures of hpol eta with a non-hydrolyzable analog of dATP or dGTP opposite an abasic site, H-bonding was observed between the phosphate 5" to the abasic site and water H-bonded to N1 and N6 of A and N1 and O6 of G nucleoside triphosphate analogs, offering an explanation for what appears to be a "purine rule."	Water	175-180	endothelin receptor type A	Homo sapiens	28-31
25977852-5	2015	Here we employ the surfaces of CaF2, on which nanoscale water films form, to report on the range and force profiles that might originate by dynamic capillary interactions occurring between an AFM tip and nanoscale water patches.	Water	56-61	CCR4-NOT transcription complex subunit 8	Homo sapiens	31-35
25977852-5	2015	Here we employ the surfaces of CaF2, on which nanoscale water films form, to report on the range and force profiles that might originate by dynamic capillary interactions occurring between an AFM tip and nanoscale water patches.	Water	214-219	CCR4-NOT transcription complex subunit 8	Homo sapiens	31-35
25793528-7	2015	The pro-inflammatory cytokine, interferon-gamma may contribute to diarrhea associated with intestinal inflammation in part through regulation of the epithelial aquaporin-1 water channel via a non-classical JAK/STAT receptor signalling pathway.	Water	172-177	aquaporin 1	Mus musculus	160-171
25611433-9	2015	Treatment with AICAR significantly decreased the gut damage score and the water content, indicating improvement in histological integrity.	Water	74-79	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	15-20
25521553-2	2015	An amphiphilic peptide designed with a cationic amino acid as a hydrophilic residue turned an anionic mica substrate into a water-repellent surface, simply by adsorbing it on the substrate surface.	Water	124-129	MHC class I polypeptide-related sequence A	Homo sapiens	102-106
25609088-0	2015	Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction.	Water	10-15	aquaporin 1	Mus musculus	35-46
25609088-1	2015	Aquaporin-1 (AQP1) enables greatly enhanced water flux across plasma membranes.	Water	44-49	aquaporin 1	Mus musculus	0-11
25609088-1	2015	Aquaporin-1 (AQP1) enables greatly enhanced water flux across plasma membranes.	Water	44-49	aquaporin 1	Mus musculus	13-17
25609088-8	2015	This motif was also necessary for CAII to increase AQP1-mediated water flux.	Water	65-70	aquaporin 1	Mus musculus	51-55
25609088-11	2015	These data are consistent with CAII increasing water conductance through AQP1 by a physical interaction between the two proteins.	Water	47-52	aquaporin 1	Mus musculus	73-77
25762321-1	2015	The renal outer medullary potassium channel (ROMK, or Kir1.1, encoded by KCNJ1) critically regulates renal tubule electrolyte and water transport and hence blood volume and pressure.	Water	130-135	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	45-49
25762321-1	2015	The renal outer medullary potassium channel (ROMK, or Kir1.1, encoded by KCNJ1) critically regulates renal tubule electrolyte and water transport and hence blood volume and pressure.	Water	130-135	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	54-60
25762321-1	2015	The renal outer medullary potassium channel (ROMK, or Kir1.1, encoded by KCNJ1) critically regulates renal tubule electrolyte and water transport and hence blood volume and pressure.	Water	130-135	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	73-78
25762321-2	2015	The discovery of loss-of-function mutations in KCNJ1 underlying renal salt and water wasting and lower blood pressure has sparked interest in developing new classes of antihypertensive diuretics targeting ROMK.	Water	79-84	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	47-52
25888997-13	2015	CONCLUSION: The results of the present study demonstrated that a GLP-1 analog and a DPP4 inhibitor may have beneficial effects on renal sodium and water handling.	Water	147-152	dipeptidylpeptidase 4	Rattus norvegicus	84-88
25638571-7	2015	On the other hand, resveratrol significantly perturbs the interaction of IAPP with negatively charged membranes by anchoring specific hydrophobic regions (23FGA25 and 32VGS34) of the peptide and forming a stable 1:2 IAPP:resveratrol complex at the water/membrane interphase.	Water	248-253	islet amyloid polypeptide	Homo sapiens	73-77
25793825-2	2015	We observe stick-slip dynamics for thin water films confined by mica sheets, involving periodic breaking-reforming transitions of atomic-scale capillary water bridges formed around the potassium ions of mica.	Water	40-45	MHC class I polypeptide-related sequence A	Homo sapiens	64-68
25793825-2	2015	We observe stick-slip dynamics for thin water films confined by mica sheets, involving periodic breaking-reforming transitions of atomic-scale capillary water bridges formed around the potassium ions of mica.	Water	40-45	MHC class I polypeptide-related sequence A	Homo sapiens	203-207
25793825-2	2015	We observe stick-slip dynamics for thin water films confined by mica sheets, involving periodic breaking-reforming transitions of atomic-scale capillary water bridges formed around the potassium ions of mica.	Water	153-158	MHC class I polypeptide-related sequence A	Homo sapiens	64-68
25793825-2	2015	We observe stick-slip dynamics for thin water films confined by mica sheets, involving periodic breaking-reforming transitions of atomic-scale capillary water bridges formed around the potassium ions of mica.	Water	153-158	MHC class I polypeptide-related sequence A	Homo sapiens	203-207
25793825-3	2015	However, only smooth sliding without stick-slip events is observed for water confined by graphene, as well as for thicker water layers confined by mica.	Water	122-127	MHC class I polypeptide-related sequence A	Homo sapiens	147-151
25662501-4	2015	The resulting C60(OH)10/HP-beta-CD nanoparticles were stable in water and showed no aggregation over a 1 month period.	Water	64-69	beta-carotene oxygenase 1	Mus musculus	27-34
25585012-0	2015	Aquaporin-1 water permeability as a novel determinant of axonal regeneration in dorsal root ganglion neurons.	Water	12-17	aquaporin 1	Mus musculus	0-11
25585012-2	2015	Water channel aquaporin-1 (AQP1) is expressed at the plasma membrane of cell bodies and axons of DRG neurons, where it modulates the sensing of certain types of pain.	Water	0-5	aquaporin 1	Mus musculus	14-25
25585012-2	2015	Water channel aquaporin-1 (AQP1) is expressed at the plasma membrane of cell bodies and axons of DRG neurons, where it modulates the sensing of certain types of pain.	Water	0-5	aquaporin 1	Mus musculus	27-31
25585012-3	2015	Here, we found that AQP1 is also involved in DRG axonal growth and regeneration by a mechanism that may involve water transport-facilitated extension of axonal outgrowths.	Water	112-117	aquaporin 1	Mus musculus	20-24
25585012-5	2015	Axonal growth in AQP1-deficient DRG cultures was rescued by transfection with AQP1 or a different water-transporting AQP (AQP4), but not by a non-water-transporting AQP1 mutant.	Water	98-103	aquaporin 1	Mus musculus	17-21
25531406-13	2015	The ratio of unknown total organic halide (UTOX) to TOX was substantially lower in the hot tap water as the THM to TOX ratio became correspondingly larger.	Water	95-100	thymocyte selection associated high mobility group box	Homo sapiens	44-47
25531406-13	2015	The ratio of unknown total organic halide (UTOX) to TOX was substantially lower in the hot tap water as the THM to TOX ratio became correspondingly larger.	Water	95-100	thymocyte selection associated high mobility group box	Homo sapiens	52-55
26448944-2	2015	MR has been traditionally associated with the control of water and electrolyte homeostasis in order to keep blood pressure through aldosterone activation.	Water	57-62	nuclear receptor subfamily 3 group C member 2	Homo sapiens	0-2
26451371-7	2015	Some of the roles that have been attributed to SLC4A11 include H(+) and NH4 (+) permeation, electrogenic Na(+)-H(+) exchange, and water transport.	Water	130-135	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Mus musculus	47-54
25161120-10	2015	Since the cilium sense and transduce mechanical and chemical stimuli, ASIC2 expression in this location might be related to detection of aquatic environment pH variations or to detection of water movement through the nasal cavity.	Water	190-195	acid-sensing (proton-gated) ion channel 2	Danio rerio	70-75
28241728-11	2017	Collectively, AKG plays an important role in increasing water and ion homeostasis through modulating the AMPK pathway.	Water	56-61	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	105-109
25581854-1	2015	Subphthalocyanine (SubPc), a putative fluorophore for optical imaging (OI), was conjugated to chelating ligands (DOTA, DTPA) affording water-soluble conjugates complexed with (non-radioactive) metals relevant to the following medical imaging techniques/therapies: MRI (Gd), PET (Cu, Ga), SPECT (In, Ga, Lu), RIT (Cu, Lu, Y), and NCT (Gd).	Water	135-140	Ras like without CAAX 1	Homo sapiens	308-311
28297654-0	2017	Role of Pore-Lining Residues in Defining the Rate of Water Conduction by Aquaporin-0.	Water	53-58	lens fiber major intrinsic protein	Ovis aries	73-84
25686321-4	2015	Activation of TRPV1 increased the intracellular Ca(2+) concentration, upregulated the expression of aquaporin 5 (AQP5), the main transporter that mediate water secretion through transcellular pathway, and led to AQP5 redistribution.	Water	154-159	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
25602335-0	2015	A STELLA Model to Estimate Water and Nitrogen Dynamics in a Short-Rotation Woody Crop Plantation.	Water	27-32	developmental pluripotency associated 3	Homo sapiens	2-8
28297654-1	2017	Compared to other aquaporins (AQPs), lens-specific AQP0 is a poor water channel, and its permeability was reported to be pH-dependent.	Water	66-71	lens fiber major intrinsic protein	Ovis aries	51-55
28297654-3	2017	Experiments with purified AQP0 reconstituted into liposomes are challenging because the water permeability of AQP0 is only slightly higher than that of pure lipid bilayers.	Water	88-93	lens fiber major intrinsic protein	Ovis aries	110-114
28297654-4	2017	By reconstituting high amounts of AQP0 and using high concentrations of cholesterol to reduce the permeability of the lipid bilayer, we improved the signal-to-noise ratio of water permeability measurements on AQP0 proteoliposomes.	Water	174-179	lens fiber major intrinsic protein	Ovis aries	34-38
31456824-0	2015	Coil-helix transition of polypeptide at water-lipid interface.	Water	40-45	coilin	Homo sapiens	0-4
28297654-4	2017	By reconstituting high amounts of AQP0 and using high concentrations of cholesterol to reduce the permeability of the lipid bilayer, we improved the signal-to-noise ratio of water permeability measurements on AQP0 proteoliposomes.	Water	174-179	lens fiber major intrinsic protein	Ovis aries	209-213
25884220-11	2015	P4, E2, AA, FSK and cAMP cause translocation of AQP5 from apical to the basolateral plasma membrane of the epithelial cells, which might affect the transcellular water movement (through epithelial cells) between uterine lumen and blood vessels.	Water	162-167	aquaporin 5	Sus scrofa	48-52
28297654-5	2017	Our measurements show that mutation of two pore-lining tyrosine residues, Tyr-23 and Tyr-149 in sheep AQP0, to the corresponding residues in the high-permeability water channel AQP1 have additive effects and together increase the water permeability of AQP0 40-fold to a level comparable to that of AQP1.	Water	163-168	lens fiber major intrinsic protein	Ovis aries	102-106
28297654-5	2017	Our measurements show that mutation of two pore-lining tyrosine residues, Tyr-23 and Tyr-149 in sheep AQP0, to the corresponding residues in the high-permeability water channel AQP1 have additive effects and together increase the water permeability of AQP0 40-fold to a level comparable to that of AQP1.	Water	163-168	lens fiber major intrinsic protein	Ovis aries	252-256
25681923-8	2015	Below Tc2 (in phase III), the reorientations of certain part of the H2O ligands significantly slow down, while others continue their fast reorientation with an activation energy of ca 2 kJ mole(-1).	Water	68-71	transcobalamin 2	Homo sapiens	6-9
26596112-3	2015	In oral intake of hyperchlorination drinkable water products, the study revealed main genes having polymorphism associated with endocrine disorders: overweight and obesity--APOE, PPARG, HTR2A, characterizing antioxidant system state--SOD2 and detoxication--SULTA.	Water	46-51	superoxide dismutase 2	Homo sapiens	234-238
28297654-5	2017	Our measurements show that mutation of two pore-lining tyrosine residues, Tyr-23 and Tyr-149 in sheep AQP0, to the corresponding residues in the high-permeability water channel AQP1 have additive effects and together increase the water permeability of AQP0 40-fold to a level comparable to that of AQP1.	Water	230-235	lens fiber major intrinsic protein	Ovis aries	102-106
25615007-2	2015	Here we report on nanophase separated patterns of water and ethanol within monomolecularly thin films confined between the cleavage plane of mica and single or a few layers of graphene.	Water	50-55	MHC class I polypeptide-related sequence A	Homo sapiens	141-145
28297654-5	2017	Our measurements show that mutation of two pore-lining tyrosine residues, Tyr-23 and Tyr-149 in sheep AQP0, to the corresponding residues in the high-permeability water channel AQP1 have additive effects and together increase the water permeability of AQP0 40-fold to a level comparable to that of AQP1.	Water	230-235	lens fiber major intrinsic protein	Ovis aries	252-256
28072485-1	2017	Water-soluble polymer nanoparticles NP-1 and NP-2 were prepared by using a three-component self-assembly of an iridium complex, poly(4-vinyl pyridine-b-ethylene oxide) (P4VP-b-PEO), and methane sulfonic acid (MSA).	Water	0-5	neuronal pentraxin 1	Mus musculus	36-40
26347850-9	2015	The protective effect of QP water extract was found to be via inhibiting MEK/ERK pathway and reversing PI3-K/Akt/GSK3beta pathway.	Water	28-33	glycogen synthase kinase 3 beta	Rattus norvegicus	113-121
28194910-4	2017	Herein, we report a hierarchical hollow FeV composite, which is Ni- and Co-free and highly efficient for electrocatalytic water oxidation with low overpotential 390 mV (10 mA cm-2 catalytic current density), low Tafel slope of 36.7 mV dec-1 , and a considerable durability.	Water	122-127	deleted in esophageal cancer 1	Homo sapiens	235-240
25127247-5	2015	Knowing that the H2O2 measured experimentally during sonication of water comes from the recombination of hydroxyl (OH) and perhydroxyl (HO2) radicals in the liquid phase and assuming that in sonochemistry applications, the cavitation is transient and the bubble fragments at the first collapse, the number of bubbles formed per unit time per unit volume is then easily determined using material balances for H2O2, OH and HO2 in the liquid phase.	Water	67-72	heme oxygenase 2	Homo sapiens	136-139
25127247-5	2015	Knowing that the H2O2 measured experimentally during sonication of water comes from the recombination of hydroxyl (OH) and perhydroxyl (HO2) radicals in the liquid phase and assuming that in sonochemistry applications, the cavitation is transient and the bubble fragments at the first collapse, the number of bubbles formed per unit time per unit volume is then easily determined using material balances for H2O2, OH and HO2 in the liquid phase.	Water	67-72	heme oxygenase 2	Homo sapiens	421-424
25519227-3	2015	We calculate the temperature (Theta) and frequency (omega) dependences of the spin-lattice NMR relaxation rates for segments and NMR active CH2 groups in poly-L-lysine (PLL) dendrimers in water, on the basis of full-atomic molecular dynamics simulations.	Water	188-193	interleukin 1 receptor like 1	Homo sapiens	52-57
25529427-2	2015	Of the aquaporins (AQP), which are a family of membrane-spanning proteins that are predominantly involved in the movement of water, AQP-3, AQP-7, and AQP-10 are also permeable to urea, but it is not clear if they contribute to urea transport across the ruminal epithelium.	Water	125-130	aquaporin 3	Bos taurus	132-137
28287453-4	2017	Both solutions require a scale factor examined by the CLM4.0 model to obtain the actual water storage signal.	Water	88-93	CD300 molecule like family member d	Homo sapiens	54-58
25514470-1	2015	A combination of atomic force microscopy (AFM) and reflection interference contrast microscopy (RICM) was used to measure simultaneously the interaction force and the spatiotemporal evolution of the thin water film between a bubble in water and mica surfaces with varying degrees of hydrophobicity.	Water	204-209	MHC class I polypeptide-related sequence A	Homo sapiens	245-249
26214870-5	2015	The influence of water extracts of crude and wine-processed Rhei Radix et Rhizoma on the activities of Na+, K-ATPase, Ca2+ -ATPase and succinic dehydrogenase(SDH) in the mice were compared.	Water	17-22	serine dehydratase	Mus musculus	158-161
25487062-2	2015	Presented herein is a Mg(2+) metal-organic framework (MOF), which exhibits the remarkable capability to rapidly detect traces of water (0.05-5 % v/v) in various organic solvents through an unusual turn-on luminescence sensing mechanism.	Water	129-134	lysine acetyltransferase 8	Homo sapiens	29-58
28772632-6	2017	Based on the interface reaction dynamics, KDP aqueous solutions with different concentrations (cKDP) were applied to replace water in the traditional water-in-oil (W/O) microemulsion.	Water	125-130	WNK lysine deficient protein kinase 1	Homo sapiens	42-45
25487062-3	2015	The extraordinary sensitivity and fast response of this MOF for water, and its reusability make it one of the most powerful water sensors known.	Water	64-69	lysine acetyltransferase 8	Homo sapiens	56-59
25487062-3	2015	The extraordinary sensitivity and fast response of this MOF for water, and its reusability make it one of the most powerful water sensors known.	Water	124-129	lysine acetyltransferase 8	Homo sapiens	56-59
25705423-0	2014	Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study.	Water	136-141	elastase, neutrophil expressed	Homo sapiens	22-41
28772632-6	2017	Based on the interface reaction dynamics, KDP aqueous solutions with different concentrations (cKDP) were applied to replace water in the traditional water-in-oil (W/O) microemulsion.	Water	150-155	WNK lysine deficient protein kinase 1	Homo sapiens	42-45
25493718-7	2015	The results suggest that in SerR, similarly to the related enzyme alanine racemase, the unprotonated PLP-substrate intermediate is stabilized mostly due to solvation effects contributed by water molecules and active-site residues, as well as long-range electrostatic interactions with the enzyme environment.	Water	189-194	serine racemase	Homo sapiens	28-32
25377662-3	2014	The RbxWO3/Rb1-yLaNb2O7 bilayer photoanodes exhibited enhanced photoelectrochemical water splitting compared with the RbxWO3 and RbLaNb2O7 monolayer photoanodes.	Water	84-89	RB transcriptional corepressor 1	Homo sapiens	11-14
25493718-7	2015	The results suggest that in SerR, similarly to the related enzyme alanine racemase, the unprotonated PLP-substrate intermediate is stabilized mostly due to solvation effects contributed by water molecules and active-site residues, as well as long-range electrostatic interactions with the enzyme environment.	Water	189-194	pyridoxal phosphatase	Homo sapiens	101-104
28192984-5	2017	Interestingly, transmission electron microscopy (TEM) and dynamic light scattering (DLS) confirmed that, in water, NDPP forms loose micelle-like fluorescent ONPs with a hydrohobic TDPP portion encapsulated inside.	Water	108-113	caspase recruitment domain family member 8	Homo sapiens	115-119
25064222-8	2014	In control group, AQP4-positive cells significantly increased after model establishment, which reached maximum on third day, and positive cells in group C were significantly less than in group A, group B and group D. We also found that AQP4 expression were positively correlated with brain tissue water content (r = 0.719, p &lt; 0.05) demonstrated by significantly increased AQP4 expression along with increased brain tissue water content.	Water	297-302	aquaporin-4	Oryctolagus cuniculus	236-240
25064222-8	2014	In control group, AQP4-positive cells significantly increased after model establishment, which reached maximum on third day, and positive cells in group C were significantly less than in group A, group B and group D. We also found that AQP4 expression were positively correlated with brain tissue water content (r = 0.719, p &lt; 0.05) demonstrated by significantly increased AQP4 expression along with increased brain tissue water content.	Water	297-302	aquaporin-4	Oryctolagus cuniculus	236-240
25064222-8	2014	In control group, AQP4-positive cells significantly increased after model establishment, which reached maximum on third day, and positive cells in group C were significantly less than in group A, group B and group D. We also found that AQP4 expression were positively correlated with brain tissue water content (r = 0.719, p &lt; 0.05) demonstrated by significantly increased AQP4 expression along with increased brain tissue water content.	Water	426-431	aquaporin-4	Oryctolagus cuniculus	236-240
25064222-8	2014	In control group, AQP4-positive cells significantly increased after model establishment, which reached maximum on third day, and positive cells in group C were significantly less than in group A, group B and group D. We also found that AQP4 expression were positively correlated with brain tissue water content (r = 0.719, p &lt; 0.05) demonstrated by significantly increased AQP4 expression along with increased brain tissue water content.	Water	426-431	aquaporin-4	Oryctolagus cuniculus	236-240
28192984-8	2017	In addition, NDPP ONPs show good water solubility and high selectivity to Hg2+ in neutral or alkalescent water.	Water	33-38	caspase recruitment domain family member 8	Homo sapiens	13-17
28192984-8	2017	In addition, NDPP ONPs show good water solubility and high selectivity to Hg2+ in neutral or alkalescent water.	Water	105-110	caspase recruitment domain family member 8	Homo sapiens	13-17
28206762-4	2017	Comparing the two possible terminations of the polar (001)-oriented surface, we find that the LaO-terminated surface is more reactive toward water, forming hydroxyl species and adsorbing molecular water at lower relative humidity than its FeO2-terminated counterpart.	Water	141-146	interleukin 4 induced 1	Homo sapiens	94-97
28206762-4	2017	Comparing the two possible terminations of the polar (001)-oriented surface, we find that the LaO-terminated surface is more reactive toward water, forming hydroxyl species and adsorbing molecular water at lower relative humidity than its FeO2-terminated counterpart.	Water	197-202	interleukin 4 induced 1	Homo sapiens	94-97
28182184-5	2017	We found electrochemical photovoltage and photocurrent responses as SPP-induced hot carriers drive both solution-based oxidation of methanol and the anodic half-reaction of photoelectrochemical water-splitting in sodium hydroxide solution.	Water	194-199	histocompatibility minor 13	Homo sapiens	68-71
25394287-6	2014	Traces of water and dioxygen in solutions of (iPr2)6/(iPr2)7 yield the di(mu-oxido) complex [Mo(V)((iPr2)L)O]2(mu-O)2 ((iPr2)4) with reduced steric congestion due to dissociation of the bulky chelate ligands.	Water	10-15	adaptor related protein complex 1 subunit mu 2	Homo sapiens	111-117
28401088-4	2017	In brief, RSL powder was fractionated into n-hexane, chloroform, ethyl acetate, n-butanol, and water-soluble fractions.	Water	95-100	regulator of sex limited protein-Slp	Mus musculus	10-13
25473302-13	2014	CONCLUSION: Our study revealed that E. coli isolates from river water exhibit a higher level of hemolysin production, beta-lactamase production, and biofilm formation than feces isolates may be due to long adaptation.	Water	64-69	beta-lactamase	Escherichia coli	118-132
28230209-4	2017	Here we follow the dynamics of single Rb+ and H3O+ ions at the surface of mica in water using high-resolution atomic force microscopy with 25 ms resolution.	Water	82-87	MHC class I polypeptide-related sequence A	Homo sapiens	74-78
25189376-0	2014	Multicycle water vapour stability of microporous breathing MOF aluminium isophthalate CAU-10-H.	Water	11-16	lysine acetyltransferase 8	Homo sapiens	59-62
25189376-4	2014	In combination with high water adsorption capacity, hydrophilic CAU-10-H is the first breathing-like MOF with a structural change which is a promising candidate for the use in heat transformation processes.	Water	25-30	lysine acetyltransferase 8	Homo sapiens	101-104
28260893-6	2017	BCA solubility in water increased to 5.0 mg/mL after encapsulation, and the drug-loading efficiency was 5.88%+-0.76%.	Water	18-23	B cell linker	Homo sapiens	0-3
25192149-8	2014	Previously it was proposed that the catalytic mechanism of DPP III is similar to that of thermolysin, which assumes exchange of five and four coordinated Zn(2+), and activation of Zn-bound water by a nearby Glu.	Water	189-194	dipeptidyl peptidase 3	Homo sapiens	59-66
28218285-3	2017	The so prepared super-hydrophobic E-DA-TiO2(Ag)@PC coatings could present the lotus leaf-like porous architectures, high adhesion stability, and especially the visible-light photocatalysis for organic contaminant degradation, thus promising the wide outdoor and indoor applications like water proofing, metal erosion protection, and surface self-cleaning.	Water	287-292	ectodysplasin A	Homo sapiens	34-38
25068494-11	2014	Consistent with these findings, osmotic gradient-driven water flow was significantly reduced in hepatocyte bile canaliculi and bile ducts isolated from Cldn2(-/-) mice, compared with Cldn2(+/+) mice.	Water	56-61	claudin 2	Mus musculus	152-157
25068494-14	2014	CONCLUSIONS: Based on studies of Cldn2(-/-) mice, claudin 2 regulates paracellular ion and water flow required for proper regulation of bile composition and flow.	Water	91-96	claudin 2	Mus musculus	50-59
28107010-3	2017	The HBP water model describes hydrogen bonds between water and CO2 explicitly.	Water	8-13	heme binding protein 1	Homo sapiens	4-7
28107010-3	2017	The HBP water model describes hydrogen bonds between water and CO2 explicitly.	Water	53-58	heme binding protein 1	Homo sapiens	4-7
28007386-3	2017	In general, the PAH levels of the water samples from Chabahar Bay were higher in postmonsoon than in premonsoon (p&lt;0.05).	Water	34-39	phenylalanine hydroxylase	Homo sapiens	16-19
25008241-2	2014	Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins that allow the movement of water, but also of small solutes, such as glycerol, across cell membranes.	Water	110-115	aquaporin 7	Homo sapiens	25-29
25008241-2	2014	Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins that allow the movement of water, but also of small solutes, such as glycerol, across cell membranes.	Water	110-115	aquaporin 10	Homo sapiens	40-45
27684563-3	2017	The OPG-chitosan gel was formulated using human OPG protein and water-soluble chitosan.	Water	64-69	TNF receptor superfamily member 11b	Homo sapiens	4-7
25341953-4	2014	We mutated the constriction of water-selective rat AQP1 to mimic that of the ammonia-permeable human AQP8 by replacing Phenylalanine 56 with histidine, Histidine 180 with isoleucine, and Cysteine 189 with glycine, alone and in combination.	Water	31-36	aquaporin 1	Rattus norvegicus	51-55
27956191-5	2017	It was found that presence of 50% or more of water soluble or swellable excipient in the ADF tablets significantly affected the tablet hardness, particle size distribution following mechanical manipulation and drug extraction while small amount (5%) of excipients had either minimal or no effect on ADPs of these tablets.	Water	45-50	destrin, actin depolymerizing factor	Homo sapiens	89-92
25162938-4	2014	Only a small water oxidation overpotential (eta) of 257 mV is needed for a current density of 80 mA cm(-2) with a Tafel slope of 53 mV per decade.	Water	13-18	endothelin receptor type A	Homo sapiens	44-47
27923930-5	2017	We report that Mg2+ assigned near imine nitrogens derive mostly from poor interpretations of electron density patterns and are most often misidentified Na+, K+, NH4+ ions, water molecules or spurious density peaks.	Water	172-177	mucin 7, secreted	Homo sapiens	15-18
28157866-1	2017	GaN&lt;sub&gt;1-x&lt;/sub&gt;Sb&lt;sub&gt;x&lt;/sub&gt; with x~5%-7% is a highly mismatched alloy predicted to have favorable properties for application as an electrode in a photoelectrochemical cell for solar water splitting.	Water	210-215	gigaxonin	Homo sapiens	0-3
25140358-3	2014	Surprisingly, a high adsorption energy (~550 meV per molecule) of water has been unveiled on C4F via density functional theory studies, implying anomalous superhydrophilicity of C4F.	Water	66-71	complement C4B (Chido blood group)	Homo sapiens	93-96
25140358-3	2014	Surprisingly, a high adsorption energy (~550 meV per molecule) of water has been unveiled on C4F via density functional theory studies, implying anomalous superhydrophilicity of C4F.	Water	66-71	complement C4B (Chido blood group)	Homo sapiens	178-181
27933691-3	2017	As a proof-of-concept, spike-like transients of a stochastic nature are reported in the current-time response of 1,2-dichloroethane(DCE) water(W) submilli-interfaces after injection of DCE-in-W emulsions.	Water	137-142	24-dehydrocholesterol reductase	Homo sapiens	132-135
25037330-1	2014	Various amounts of carboxyl groups were introduced at C-6 of the non-ionic, water soluble polysaccharide, i.e. pullulan, by applying the well-established TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl), sodium hypochlorite/sodium bromide oxidation protocol, varying the reaction time.	Water	76-81	complement C6	Homo sapiens	54-57
27933691-3	2017	As a proof-of-concept, spike-like transients of a stochastic nature are reported in the current-time response of 1,2-dichloroethane(DCE) water(W) submilli-interfaces after injection of DCE-in-W emulsions.	Water	137-142	24-dehydrocholesterol reductase	Homo sapiens	185-188
27497091-4	2017	Besides these roles, some TRP channels control endothelial/epithelial barrier functions and vascular integrity, while KCa3.1 channels provide the driving force required for Cl- and water transport in some cells and most secretory epithelia.	Water	181-186	potassium calcium-activated channel subfamily N member 4	Homo sapiens	118-124
25336922-6	2014	Moreover, Te-PC and Te-APC showed dose-dependent protection on erythrocytes against the water-soluble free radical initiator 2,2"-azo(2-asmidinopropane)dihydrochloride-induced hemolysis.	Water	88-93	APC regulator of WNT signaling pathway	Homo sapiens	23-26
28258571-1	2017	Several aquaporin (AQP )-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 -6 in the collecting duct; AQP7 in the proximal tubule; AQP8 in the proximal tubule and collecting duct; and AQP11 in the endoplasmic reticulum of proximal tubule cells.	Water	30-35	aquaporin 1	Mus musculus	70-74
25031229-4	2014	SST-14 and cortistatin (CST-14) (1 mug/rat icv) increased water intake by 3.1- and 2.7-fold, respectively, while both peptides did not alter food intake at 1 h postinjection in the light phase.	Water	58-63	cortistatin	Rattus norvegicus	11-22
27356941-1	2017	AMP-activated protein kianse (AMPK) is a master sensor of cellular energy levels and a crucial regulator of nutrient metabolism such as the synthesis of fatty acids, glucose and protein as well as their oxidation to CO2 and water .	Water	224-229	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-28
25150542-5	2014	In the current studies we tested the hypothesis that chronically exposing infant rats to CORT, either indirectly (through maternal drinking water) or directly (via insertion of an osmotic pump), leads to an early transition into the adult-like extinction system (i.e., evidence of the renewal effect).	Water	140-145	cortistatin	Rattus norvegicus	89-93
27356941-1	2017	AMP-activated protein kianse (AMPK) is a master sensor of cellular energy levels and a crucial regulator of nutrient metabolism such as the synthesis of fatty acids, glucose and protein as well as their oxidation to CO2 and water .	Water	224-229	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	30-34
27836116-10	2017	The highest concentration of TEGDMA was 146mug/mL for SDR Bulk fill at a layer thickness of 6mm after 7 d in water.	Water	109-114	caveolae associated protein 2	Homo sapiens	54-57
25016431-3	2014	Here, a cyclometalated iridium(III) solvent complex [Ir(pdz)2(H2O)2](+)[OTf](-) (IrC1) was designed and synthesized as a phosphorescent indicator of cell death.	Water	62-65	CD300a molecule	Homo sapiens	81-85
26677774-7	2015	Water is treated as a co-reactant for unfurling the affinity studies in ZFP-DNA binding equilibria that takes into account the unavoidable change in hydration that occurs when these two solvated surfaces come into contact.	Water	0-5	zinc finger with KRAB and SCAN domains 7	Homo sapiens	72-75
28607573-4	2017	Our data also indicated differentially expressed genes (DEGs) related to water metabolism involved secretion, ion transport, water homeostasis, regulation of body fluid levels, and water channel activity; the expression of AQP1, AQP3, AQP4, AQP5, AQP6, and AQP8 was improved; calcium, cAMP, MAPK, PPAR, AMPK, and PI3K-Akt signaling pathway may be related to water metabolism.	Water	73-78	aquaporin 1	Rattus norvegicus	223-227
26236385-5	2015	Here, we show that KRG water extract increases the expression of TrxR1 in human umbilical vein endothelial cells via the p38 and PKC-delta signaling pathways.	Water	23-28	protein kinase C delta	Homo sapiens	129-138
28697571-6	2017	The open field test, Morris water maze test, and fear condition test revealed that PSD-93 overexpression ameliorated spatial memory deficits in APP/PS1 mice.	Water	28-33	discs large MAGUK scaffold protein 2	Mus musculus	83-89
25262292-1	2015	An annual-basis study of the impacts of the anthropogenic inputs from Fez urban area on the water geochemistry of the Sebou and Fez Rivers was conducted mostly focusing on base flow conditions, in addition to the sampling of industrial wastewater characteristic of the various pressures in the studied environment.	Water	92-97	FEZ family zinc finger 1	Homo sapiens	70-73
25262292-1	2015	An annual-basis study of the impacts of the anthropogenic inputs from Fez urban area on the water geochemistry of the Sebou and Fez Rivers was conducted mostly focusing on base flow conditions, in addition to the sampling of industrial wastewater characteristic of the various pressures in the studied environment.	Water	92-97	FEZ family zinc finger 1	Homo sapiens	128-131
25262292-7	2015	Conversely, most of the studied trace metals/metalloids, originated from anthropogenic sources, underwent significant changes of Kd and behaved non-conservatively in the Sebou/Fez water mixing.	Water	180-185	FEZ family zinc finger 1	Homo sapiens	176-179
27514909-4	2017	When a water sample without antibiotics is applied to the paper discs, beta-galactosidase can be synthesized, and it hydrolyzes a colorimetric substrate, resulting in a color change from yellow to purple.	Water	7-12	galactosidase beta 1	Homo sapiens	71-89
25544246-8	2014	The strongest affinity to water was observed on the ZIC cHILIC stationary phases, where more than nine water layer equivalents were adsorbed onto its surface at its saturation capacity.	Water	26-31	Zic family member 1	Homo sapiens	52-55
25544246-8	2014	The strongest affinity to water was observed on the ZIC cHILIC stationary phases, where more than nine water layer equivalents were adsorbed onto its surface at its saturation capacity.	Water	103-108	Zic family member 1	Homo sapiens	52-55
24607774-6	2014	However, various animal studies indicate that blocking the renal tubular ETAR and ETBR causes water and salt retention partially mediated via the epithelial sodium transporter in tubular cells.	Water	94-99	endothelin receptor type A	Homo sapiens	73-77
25251501-1	2014	A new heteropolyoxovanadium compound, [NaV6O6{(OCH2CH2)2NH}6] (OH)0.5Cl0.5 3(H2O), was synthesized and characterized by single-crystal X-ray diffraction analysis, cyclic voltammetry, FTIR and UV-vis spectroscopy, and TGA.	Water	77-80	T-box transcription factor 1	Homo sapiens	217-220
27871117-1	2017	A water-soluble polysaccharide (SCP-80-I) was isolated from sweet corncob using microwave-assisted compound-enzyme extraction and column chromatography.	Water	2-7	cysteine-rich secretory protein 3	Rattus norvegicus	32-35
25258405-9	2014	Myo5b kd cells showed a decrease in net water absorption that could be reverted with PDK1 inhibitors.	Water	40-45	myosin VB	Homo sapiens	0-5
27956722-15	2017	A strap tightness of at least 45 cm H2O is required for reliable vHIT recording and gain calculations.	Water	36-39	serine/threonine kinase receptor associated protein	Homo sapiens	2-7
25119450-9	2014	Under a constant water level, the abundance of Daphnia spp.	Water	17-22	histocompatibility minor 13	Homo sapiens	55-58
27595571-6	2017	Growth assays of yeast cells expressing these mutated HvPIP2;5 proteins suggested that Ser-126 in HvPIP2;5 has a large impact on H2 O2 transport with a minor influence on the HvPIP2;5-mediated water transport.	Water	193-198	PIP2;5	Hordeum vulgare	54-62
25070268-8	2014	Gonad morphological masculinization as well as the decrease of vitellogenin persisted after depuration over 40 d in clean water.	Water	122-127	vitellogenin	Danio rerio	63-75
27595571-6	2017	Growth assays of yeast cells expressing these mutated HvPIP2;5 proteins suggested that Ser-126 in HvPIP2;5 has a large impact on H2 O2 transport with a minor influence on the HvPIP2;5-mediated water transport.	Water	193-198	PIP2;5	Hordeum vulgare	98-106
27595571-6	2017	Growth assays of yeast cells expressing these mutated HvPIP2;5 proteins suggested that Ser-126 in HvPIP2;5 has a large impact on H2 O2 transport with a minor influence on the HvPIP2;5-mediated water transport.	Water	193-198	PIP2;5	Hordeum vulgare	98-106
25752050-0	2014	[Experimental research of turbidity influence on water quality monitoring of COD in UV-visible spectroscopy].	Water	49-54	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	77-80
27756127-6	2016	When ions traveled through nanopores, Li+ had to overcome a greater energy barrier than Mg2+ because it had to shed more water molecules and break more hydrogen bonds in the second hydration shell compared with Mg2+.	Water	121-126	mucin 7, secreted	Homo sapiens	88-91
25752050-7	2014	Then we make multiplicative scatter correction for the three selected UV liquid-visible absorption spectroscopy, experimental results shows that on the premise of saving the characteristic of the Ultraviolet-Visible absorption spectrum of water samples, which not only improve the quality of COD spectroscopy detection SNR, but also for providing an efficient data conditioning regimen for establishing an accurate of the chemical measurement methods.	Water	239-244	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	292-295
27989170-1	2016	A highly stable layered zirconium phosphate, (NH4)2[ZrF2(HPO4)2] (ZrP-1), was synthesized by an ionothermal method and contains an extremely dense two-dimensional hydrogen-bond network that is thermally stable up to 573 K, leading to combined ultrahigh water-assisted proton conductivities of 1.45 x 10-2 S cm-1 at 363 K/95% relative humidity and sustainable anhydrous proton conductivity of 1.1 x 10-5 S cm-1 at 503 K.	Water	253-258	thyroid hormone receptor interactor 6	Homo sapiens	66-71
25205065-4	2014	Under electrochemical conditions, water oxidation is conducted on the deposited indium-tin-oxide anode, and a turnover number higher than 15,000 per water oxidation catalyst (WOC) 1 is obtained during 10 h of electrolysis under 1.42 V vs. NHE, corresponding to a turnover frequency of 0.41 s(-1).	Water	34-39	solute carrier family 9 member C1	Homo sapiens	239-242
25205065-4	2014	Under electrochemical conditions, water oxidation is conducted on the deposited indium-tin-oxide anode, and a turnover number higher than 15,000 per water oxidation catalyst (WOC) 1 is obtained during 10 h of electrolysis under 1.42 V vs. NHE, corresponding to a turnover frequency of 0.41 s(-1).	Water	149-154	solute carrier family 9 member C1	Homo sapiens	239-242
27897422-3	2016	These hybrid solid state materials are exceptionally stable molecular water-oxidation anodes capable of carrying out more than a million turnover numbers (TNs) at pH 7 with an Eapp =1.45 V vs. NHE without any sign of degradation.	Water	70-75	solute carrier family 9 member C1	Homo sapiens	193-196
25197950-8	2014	SPR was used to measure the amount of bound polyamines, and when combined with QCM-D, the data indicate that the layer condensation leads to a small release of water from the highly hydrated DNA films.	Water	160-165	sepiapterin reductase	Homo sapiens	0-3
25198146-2	2014	The MOF can be treated with liquid water, leading to the reversible displacement of 50% of its pillars by water molecules and resulting in a most unusual crystalline and permanently porous structure.	Water	35-40	lysine acetyltransferase 8	Homo sapiens	4-7
25198146-2	2014	The MOF can be treated with liquid water, leading to the reversible displacement of 50% of its pillars by water molecules and resulting in a most unusual crystalline and permanently porous structure.	Water	106-111	lysine acetyltransferase 8	Homo sapiens	4-7
27784676-7	2016	Moreover, knockdown of NCC prevented the increased uptake of both Na+ and Cl- after exposure to acidic water.	Water	103-108	solute carrier family 12 member 3	Homo sapiens	23-26
25007996-1	2014	Ang II, the primary effector pleiotropic hormone of the renin-angiotensin system (RAS) cascade, mediates physiological control of blood pressure and electrolyte balance through its action on vascular tone, aldosterone secretion, renal sodium absorption, water intake, sympathetic activity and vasopressin release.	Water	254-259	angiogenin	Homo sapiens	0-3
27210243-3	2016	All patients had undergone dynamic magnetic resonance imaging (MRI) with chemical-shift-encoded water-fat imaging (CSI).	Water	96-101	FAT atypical cadherin 1	Homo sapiens	102-105
24951857-6	2014	Pharmacogenetic stimulation of orexin neurons simultaneously increased locomotive activity, food intake, water intake and the respiratory exchange ratio (RER).	Water	105-110	hypocretin	Mus musculus	31-37
24951857-8	2014	Accordantly, 83% ablation of orexin neurons resulted in decreased food and water intake, while 70% ablation had almost no effect on these parameters.	Water	75-80	hypocretin	Mus musculus	29-35
28115760-0	2016	The improvement effect and mechanism of citrus fiber on the water-binding ability of low-fat frankfurters.	Water	60-65	FAT atypical cadherin 1	Homo sapiens	89-92
32481889-1	2014	Water dispersible Gd3+,Yb3+,Er3+ and Gd3+,Yb3+,Tm3+ doped CaF2 nanoparticles (NPs) were prepared by one-pot hydrothermal synthesis using citrate ions as capping agents without the need for any post-synthesis reaction.	Water	0-5	CCR4-NOT transcription complex subunit 8	Homo sapiens	58-62
28115760-1	2016	Water-binding ability is a major quality attribute of low-fat meat products.	Water	0-5	FAT atypical cadherin 1	Homo sapiens	58-61
24990857-5	2014	The remainder may be due to the Cl(-)/HCO3 (-) exchanger and Na(+)-Cl(-) cotransporter (NCC), since inhibitors for these transporters almost nullified the remaining water absorption.	Water	165-170	solute carrier family 12 member 3	Homo sapiens	61-86
28115760-2	2016	This study aimed to evaluate the effects of citrus fiber on the water-binding ability of low-fat frankfurters.	Water	64-69	FAT atypical cadherin 1	Homo sapiens	93-96
24990857-5	2014	The remainder may be due to the Cl(-)/HCO3 (-) exchanger and Na(+)-Cl(-) cotransporter (NCC), since inhibitors for these transporters almost nullified the remaining water absorption.	Water	165-170	solute carrier family 12 member 3	Homo sapiens	88-91
28115760-9	2016	In conclusion, citrus fiber effectively improved the water-binding ability of low-fat frankfurters by increasing the hydrophobic interactions of myofibrillar proteins and changing the frankfurter microstructure.	Water	53-58	FAT atypical cadherin 1	Homo sapiens	82-85
27752975-3	2016	properties of highly crystalline water-dispersible CaF2:Ce/Tb nanocrystals (core-nanocrystals).	Water	33-38	CCR4-NOT transcription complex subunit 8	Homo sapiens	51-55
25199026-2	2014	Here we investigate the condensation of water vapour occurring in both the hydrophobic-hydrophilic interface (graphene/mica) and the hydrophilic-hydrophilic interface (MoS2/mica) by in situ thermally controlled atomic force microscopy.	Water	40-45	MHC class I polypeptide-related sequence A	Homo sapiens	119-123
25199026-2	2014	Here we investigate the condensation of water vapour occurring in both the hydrophobic-hydrophilic interface (graphene/mica) and the hydrophilic-hydrophilic interface (MoS2/mica) by in situ thermally controlled atomic force microscopy.	Water	40-45	MHC class I polypeptide-related sequence A	Homo sapiens	173-177
27102906-0	2016	AM-DMC-AMPS Multi-Functionalized Magnetic Nanoparticles for Efficient Purification of Complex Multiphase Water System.	Water	105-110	adenylosuccinate lyase	Homo sapiens	7-11
25186362-2	2014	Water-rich aluminium halide hydrates: AlCl3   15H2O, AlBr3   15H2O, AlI3   15H2O, AlI3   17H2O and AlBr3   9H2O.	Water	0-5	adhesion molecule with Ig like domain 3	Homo sapiens	68-72
25186362-2	2014	Water-rich aluminium halide hydrates: AlCl3   15H2O, AlBr3   15H2O, AlI3   15H2O, AlI3   17H2O and AlBr3   9H2O.	Water	0-5	adhesion molecule with Ig like domain 3	Homo sapiens	82-86
24986423-1	2014	Vascular endothelial growth factor (VEGF), a cytokine that increases vascular permeability to water and proteins and induces angiogenesis, has been implicated in the development of pleural effusions.	Water	94-99	vascular endothelial growth factor A	Ovis aries	0-34
24986423-1	2014	Vascular endothelial growth factor (VEGF), a cytokine that increases vascular permeability to water and proteins and induces angiogenesis, has been implicated in the development of pleural effusions.	Water	94-99	vascular endothelial growth factor A	Ovis aries	36-40
27696322-1	2016	A novel method of fabricating water-soluble bio-probes with ultra-small size such as NaYF4:Yb,Er (18 nm), NaGdF4:Yb,Er (8 nm), CaF2:Yb,Er (10 nm), PbS (7 nm), and ZnS (12 nm) has been developed to provide for the solubility switch of nanoparticles from oil-soluble to water-soluble in terms of hydrion rivalry aided by ultrasonic.	Water	30-35	CCR4-NOT transcription complex subunit 8	Homo sapiens	127-131
25422551-14	2014	RESULTS: The water-extraction of Astragali Radix and Lycopi Herba significantly lowered fasting glucose and urine albumin in diabetic rats through inhibition of TGF-beta1 mRNA and protein expression in the STZ-induced diabetic rats, and regulation of the Smad3, Smad7, Smurf1, Smurf2 mRNA and protein expression, as well as elevated 26S proteasome activity to play control effect in DN.	Water	13-18	SMAD specific E3 ubiquitin protein ligase 1	Rattus norvegicus	269-275
25000480-1	2014	The mineralocorticoid receptor (MR) plays a central role in salt and water homeostasis via the kidney; however, inappropriate activation of the MR in the heart can lead to heart failure.	Water	69-74	nuclear receptor subfamily 3 group C member 2	Homo sapiens	4-30
25000480-1	2014	The mineralocorticoid receptor (MR) plays a central role in salt and water homeostasis via the kidney; however, inappropriate activation of the MR in the heart can lead to heart failure.	Water	69-74	nuclear receptor subfamily 3 group C member 2	Homo sapiens	32-34
25739268-5	2014	The effects of the contents of water, salt concentration and pH on the retention of nucleosides and nucleic acid bases were respectively investigated, and the results indicated that Sil-IEASP is of hydrophilic interaction chromatographic nature.	Water	31-36	STIL centriolar assembly protein	Homo sapiens	182-185
27669396-5	2016	Water use efficiency increased at 2 DPI in D, DV, and V, but at 6 DPI only in D and DV compared to C. Photochemical parameters (effective quantum efficiency of photosystem II and electron transport rate) decreased in D and DV compared to C, especially at 6 DPI.	Water	0-5	angiotensin II receptor type 2	Homo sapiens	31-35
25246974-3	2014	Alcohols were activated as 3,5-bis(trifluoromethyl)-substituted benzoates and irradiation with blue light in the presence of [Ir(ppy)2(dtb-bpy)](PF6) as visible light photocatalyst and Hunig"s base as sacrificial electron donor in an acetonitrile/water mixture generally gave good to excellent yields of the desired defunctionalized compounds.	Water	247-252	sperm associated antigen 17	Homo sapiens	145-148
25318172-3	2014	Higher relative water content (by 13%) and superoxide dismutase (SOD) activity, lower electrolyte leakage (up 1.4-fold) and smaller increase in chlorophyll a and carotenoid contents in cyp11A1 canola leaves in comparison with wild-type plants under stress allowed to conclude cyp11A1 plants are more tolerant to high temperature than the control ones.	Water	16-21	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	185-192
27896585-3	2016	DBA/1J mice were orally administered the water extract of CPN (100 and 500 mg/kg) and indomethacin (1 mg/kg) or vehicle (water) 3 times per week for 6 weeks.	Water	41-46	carboxypeptidase N, polypeptide 1	Mus musculus	58-61
25005536-3	2014	This Perspective article focuses on the catalytic applications in aqueous media of (eta(6)-arene)-ruthenium(ii) complexes containing water-soluble phosphines, and related hydrophilic P-donor ligands.	Water	133-138	endothelin receptor type A	Homo sapiens	84-87
27450342-3	2016	Further kinetic analysis reveals that the oxidation of individual PAH in the biphasic tar/water system follows the first-order kinetics, and individual PAH oxidation rate is primary determined by the mass transfer coefficients, tar/water interfacial areas, the aqueous solubility of individual PAH and its concentration in coal tar.	Water	90-95	phenylalanine hydroxylase	Homo sapiens	66-69
25184686-7	2014	It would be tempting to suggest that AQP3 and AQP1 are involved in the secretion of water into milk.	Water	84-89	aquaporin 1	Rattus norvegicus	46-50
25044119-1	2014	Aquaporin 0 (AQP0) is an integral membrane protein that facilitates water transport and cellular adhesion in the lens.	Water	68-73	major intrinsic protein of lens fiber	Bos taurus	0-11
25044119-1	2014	Aquaporin 0 (AQP0) is an integral membrane protein that facilitates water transport and cellular adhesion in the lens.	Water	68-73	major intrinsic protein of lens fiber	Bos taurus	13-17
25007886-6	2014	These SLC4A11 mutants, expressed in HEK293 cells, had defects in either their cell surface expression or functional activity (rate of osmotically driven water flux).	Water	153-158	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Mus musculus	6-13
27450342-3	2016	Further kinetic analysis reveals that the oxidation of individual PAH in the biphasic tar/water system follows the first-order kinetics, and individual PAH oxidation rate is primary determined by the mass transfer coefficients, tar/water interfacial areas, the aqueous solubility of individual PAH and its concentration in coal tar.	Water	232-237	phenylalanine hydroxylase	Homo sapiens	66-69
24771509-6	2014	These miRs silenced ZO-1 and ZO-2 to compromise tight junction function, resulting in leaky skin as measured by transepidermal water loss (TEWL).	Water	127-132	tight junction protein 2	Homo sapiens	29-33
24871046-0	2014	TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective.	Water	74-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
24871046-0	2014	TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective.	Water	74-79	transient receptor potential cation channel subfamily M member 8	Homo sapiens	18-23
24871046-8	2014	It is demonstrated how and why these TRP channels (TRPV1, TRP ankyrin type 1 (TRPA1), and TRP melastatin type 8 (TRPM8)) are important to start up a systemic response of energy expenditure, energy allocation, and water retention and how this is linked to a continuously activated immune system in chronic inflammatory diseases.	Water	213-218	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
24871046-8	2014	It is demonstrated how and why these TRP channels (TRPV1, TRP ankyrin type 1 (TRPA1), and TRP melastatin type 8 (TRPM8)) are important to start up a systemic response of energy expenditure, energy allocation, and water retention and how this is linked to a continuously activated immune system in chronic inflammatory diseases.	Water	213-218	transient receptor potential cation channel subfamily A member 1	Homo sapiens	58-76
24871046-8	2014	It is demonstrated how and why these TRP channels (TRPV1, TRP ankyrin type 1 (TRPA1), and TRP melastatin type 8 (TRPM8)) are important to start up a systemic response of energy expenditure, energy allocation, and water retention and how this is linked to a continuously activated immune system in chronic inflammatory diseases.	Water	213-218	transient receptor potential cation channel subfamily A member 1	Homo sapiens	78-83
24871046-8	2014	It is demonstrated how and why these TRP channels (TRPV1, TRP ankyrin type 1 (TRPA1), and TRP melastatin type 8 (TRPM8)) are important to start up a systemic response of energy expenditure, energy allocation, and water retention and how this is linked to a continuously activated immune system in chronic inflammatory diseases.	Water	213-218	transient receptor potential cation channel subfamily M member 8	Homo sapiens	90-111
24871046-8	2014	It is demonstrated how and why these TRP channels (TRPV1, TRP ankyrin type 1 (TRPA1), and TRP melastatin type 8 (TRPM8)) are important to start up a systemic response of energy expenditure, energy allocation, and water retention and how this is linked to a continuously activated immune system in chronic inflammatory diseases.	Water	213-218	transient receptor potential cation channel subfamily M member 8	Homo sapiens	113-118
24731472-1	2014	Application of Advanced Oxidation Processes (AOP) such as sono, photo and sonophoto catalysis in the purification of polluted water under ambient conditions involve the formation and participation of Reactive Oxygen Species (ROS) like  OH, HO2 , O2(-), H2O2 etc.	Water	126-131	heme oxygenase 2	Homo sapiens	240-243
25105470-3	2014	In this report, we systematically characterize the water dynamics at the interface and in the active site of a tight binding polymerase (pol beta) in its binary complex and ternary state using tryptophan as a local optical probe.	Water	51-56	DNA polymerase beta	Homo sapiens	137-145
25114210-1	2014	Cytochrome c oxidase (CcO) uses the energy released by reduction of O2 to H2O to drive eight charges from the high pH to low pH side of the membrane, increasing the electrochemical gradient.	Water	74-77	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
25114210-1	2014	Cytochrome c oxidase (CcO) uses the energy released by reduction of O2 to H2O to drive eight charges from the high pH to low pH side of the membrane, increasing the electrochemical gradient.	Water	74-77	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
24875439-2	2014	The state of the art of MOF stability in water, a crucial issue to many applications in which MOFs are promising candidates, is discussed here.	Water	41-46	lysine acetyltransferase 8	Homo sapiens	24-27
24875439-5	2014	Water adsorption properties of more than 60 MOF samples are reported.	Water	0-5	lysine acetyltransferase 8	Homo sapiens	44-47
26278096-1	2014	The behavior of water confined in MIL-53(Cr), a flexible metal-organic framework (MOF), is investigated through computational infrared spectroscopy.	Water	16-21	lysine acetyltransferase 8	Homo sapiens	57-86
24911396-4	2014	The dG-O serves as a moisture barrier for water-soluble PVA, and the dG-O/PVA composite films were shown to be effective humidity sensors over the relative humidity range 40-100%.	Water	42-47	diego	Drosophila melanogaster	4-8
25013908-2	2014	Here, we improved the solubility of pedunculoside (PE) by generating a water-soluble inclusion complex composed of PE and the polymer beta-cyclodextrin (CDP).	Water	71-76	cut like homeobox 1	Homo sapiens	153-156
25013908-6	2014	In contrast to the low solubility of PE, the water-solubility of the PE-CDP complex was greatly enhanced.	Water	45-50	cut like homeobox 1	Homo sapiens	72-75
25013908-9	2014	As a result, the formation of inclusion complexes by water-soluble CDP opens up possible aqueous applications of insoluble drug candidates in drug delivery.	Water	53-58	cut like homeobox 1	Homo sapiens	67-70
25019638-2	2014	With optimal conditions, the proposed probe P showed good selectivity to Mg2+ compared to other common metal ions, and worked in a wide linear range of 5.0 x 10(-7)-6.0 x 10(-6) M with a detection limit of 1.7 x 10(-7) M Mg2+ in ethanol-water solution (9:1, v/v, 20 mM HEPES, pH = 10.0).	Water	237-242	mucin 7, secreted	Homo sapiens	73-76
25019638-2	2014	With optimal conditions, the proposed probe P showed good selectivity to Mg2+ compared to other common metal ions, and worked in a wide linear range of 5.0 x 10(-7)-6.0 x 10(-6) M with a detection limit of 1.7 x 10(-7) M Mg2+ in ethanol-water solution (9:1, v/v, 20 mM HEPES, pH = 10.0).	Water	237-242	mucin 7, secreted	Homo sapiens	221-224
25842512-2	2014	Most organized crystallographic pattern was shown to observe in a drop of water after treatment Bioptron lamp (content of liquid-crystal associates (LCA)--6.90 +- 0.23), and stored in a silver vessel (content LCA--6.28 +- 0.17), and the least organized, almost amorphous precipitate is formed in a drop of water stored in plastic containers (content LCA--2.92 +- 0.15%).	Water	74-79	retinoid isomerohydrolase RPE65	Homo sapiens	350-356
25082856-0	2014	Arabidopsis SNAREs SYP61 and SYP121 coordinate the trafficking of plasma membrane aquaporin PIP2;7 to modulate the cell membrane water permeability.	Water	129-134	syntaxin of plants 121	Arabidopsis thaliana	29-35
25272505-8	2014	Aconiti Kusnezoffii Radix water decoction could keep body temperature, blood oxygen saturation, red cell ATPase and blood rheology, and improve intratumor hypoxia, capillary permeability and GJIC in tumor bearing mice, which led to slower tumor growth and less metastasis.	Water	26-31	dynein, axonemal, heavy chain 8	Mus musculus	105-111
24957380-7	2014	However, upon ingestion of iodine in the drinking water, autoimmune thyroiditis does develop in Tg-BID transgenic mice, as shown by a significant increase in anti-Tg antibody and mononuclear cell infiltration in the thyroid glands in 30% of mice tested.	Water	50-55	BH3 interacting domain death agonist	Mus musculus	96-102
24874819-11	2014	In stark contrast to protonated adenine, more than one solvating water molecule is required to re-establish the absorption of ThyH(+) and UraH(+) in aqueous solution.	Water	65-70	urate (hydroxyiso-) hydrolase, pseudogene	Homo sapiens	138-142
24741673-5	2014	According to the computed energy barriers of water exchange reactions, it was found that the reactivity of eta-OH2 decreases as a function of fluorine bridges.	Water	45-50	endothelin receptor type A	Homo sapiens	107-110
24328827-9	2014	For all AQP1 constructs, infection increased AQP1 protein levels, water permeability, and the change in cell volume induced by hypotonic challenge.	Water	66-71	aquaporin 1	Rattus norvegicus	8-12
24328827-11	2014	Our results suggest that AQP1 controls proliferation and migration in PASMCs and that the mechanism requires the C-terminal tail of the protein but is independent of water transport or the EF-hand motif.	Water	166-171	aquaporin 1	Rattus norvegicus	25-29
25024958-9	2014	VUR occurred at a lower intravesical pressure compared to that known as the critical detrusor pressure (&gt;=40 cm H2O) required for the development of VUR.	Water	115-118	VUR	Homo sapiens	0-3
25024958-9	2014	VUR occurred at a lower intravesical pressure compared to that known as the critical detrusor pressure (&gt;=40 cm H2O) required for the development of VUR.	Water	115-118	VUR	Homo sapiens	152-155
24636993-9	2014	These results demonstrate that GATA2 regulates the Aqp2 gene expression in CD cells and contributes to the maintenance of the body water homeostasis.	Water	131-136	GATA binding protein 2	Mus musculus	31-36
24736110-4	2014	RESULTS: The iCAT Classic extended height acquisition with 4-cm central overlap and reconstruction of 2 groups of 300 projections per rotation for the water and quality-assurance CBCT phantoms resulted in improved apparent density fidelity.	Water	151-156	catenin beta interacting protein 1	Homo sapiens	13-17
24728046-0	2014	Water-soluble multidentate polymers compactly coating Ag2S quantum dots with minimized hydrodynamic size and bright emission tunable from red to second near-infrared region.	Water	0-5	angiotensin II receptor type 1	Homo sapiens	54-58
24832299-4	2014	In this paper we use the grand canonical Monte Carlo technique and an atomistic force field to simulate the behavior of a mica supported phospholipid bilayer in pure water as a function of the distance between the bilayer and the support.	Water	166-171	MHC class I polypeptide-related sequence A	Homo sapiens	122-126
24705959-9	2014	Ten nucleosides and bases were separated, using only water as the mobile phase, within a very short time using the Sil-poly(ImC18-AAL), which is otherwise difficult to achieve using conventional hydrophobic columns such as ODS.	Water	53-58	STIL centriolar assembly protein	Homo sapiens	115-118
24565525-3	2014	DOX-miR-34a co-loaded HA-CS NPs were successfully prepared through ionotropic gelation method in water.	Water	97-102	microRNA 34a	Homo sapiens	4-11
25390002-5	2014	SGK1 is a member of the serine/threonine kinase gene family that plays an important role in the absorption of Na+ and water through the Na+ channel in the apical membrane of tubular epithelial cells.	Water	118-123	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	0-4
24356714-2	2014	Recently, however, central actions of SCT have drawn intense research interest and are supported by the broad distribution of SCT in specific neuronal populations and by in vivo physiological studies regarding its role in water homeostasis and food intake.	Water	222-227	secretin	Mus musculus	38-41
24410201-2	2014	The objective of this study is to investigate the effect of time period of basic fibroblast growth factor (bFGF) release that is modified by the hydrogel water content, on the bone regeneration.	Water	154-159	fibroblast growth factor 2	Mus musculus	75-105
24410201-2	2014	The objective of this study is to investigate the effect of time period of basic fibroblast growth factor (bFGF) release that is modified by the hydrogel water content, on the bone regeneration.	Water	154-159	fibroblast growth factor 2	Mus musculus	107-111
24410201-4	2014	The gelatin hydrogels incorporating bFGF exhibited significantly stronger bone regeneration than the bFGF solution, although the extent depended on the water content of hydrogels.	Water	152-157	fibroblast growth factor 2	Mus musculus	36-40
24410201-5	2014	Bone regeneration induced by gelatin hydrogels incorporating bFGF increased with a decrease in their water content.	Water	101-106	fibroblast growth factor 2	Mus musculus	61-65
24410201-6	2014	Histological and biochemical examinations indicated that the area of bone tissue newly formed and the level of osteogenic genes were enhanced for the hydrogels incorporating bFGF of lower water content compared with those of higher one.	Water	188-193	fibroblast growth factor 2	Mus musculus	174-178
24964631-1	2014	OBJECTIVE: To detect ERbeta mRNA expression of subjects exposed to different arsenic drinking water, and to analyze the potential relationship between their abnormal expression and heart injury caused by arsenic in order to study the endocrine disturbing effect of arsenic.	Water	94-99	estrogen receptor 2	Homo sapiens	21-27
24964631-4	2014	RESULTS: The level of ERbeta mRNA expression rose with increasing of water As and urine As (r = 0.159, 0.21, P &lt; 0.05).	Water	69-74	estrogen receptor 2	Homo sapiens	22-28
24584511-0	2014	Heme bound amylin self-assembled monolayers on an Au electrode: an efficient bio-electrode for O2 reduction to H2O.	Water	111-114	islet amyloid polypeptide	Homo sapiens	11-17
24584511-1	2014	Self-assembled monolayers of the water soluble hydrophilic part of naturally occurring amylin and its Arg11 mutant have been assembled on an Au surface, which are found to efficiently catalyze selective 4e(-)/4H(+) O2 reduction reaction (ORR) upon binding heme with a kcat of ~10(7) M(-1) s(-1) under ambient conditions, where the Arg11 residue plays the key role of proton transfer in determining the rate of ORR.	Water	33-38	islet amyloid polypeptide	Homo sapiens	87-93
24654998-6	2014	The mass of the adsorbed mucin layers, including the adsorbed mucin and water trapped in the layer, was found to be significantly higher for PSGL-1/mIgG2b than for BSM.	Water	72-77	mucin 1, cell surface associated	Bos taurus	25-30
32481991-3	2014	The surfaces of the CLAC modified PES membranes were characterized using X-ray photoelectron spectroscopic analysis, Fourier transform infrared and water contact angle measurements.	Water	148-153	collagen type XXV alpha 1 chain	Homo sapiens	20-24
24356583-1	2014	The APEX software predicts the photochemical transformation kinetics of xenobiotics in surface waters as a function of: photoreactivity parameters (direct photolysis quantum yield and second-order reaction rate constants with transient species, namely  OH, CO3(-) , (1)O2 and the triplet states of chromophoric dissolved organic matter, (3)CDOM*), water chemistry (nitrate, nitrite, bicarbonate, carbonate, bromide and dissolved organic carbon, DOC), and water depth (more specifically, the optical path length of sunlight in water).	Water	95-100	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	4-8
24356583-1	2014	The APEX software predicts the photochemical transformation kinetics of xenobiotics in surface waters as a function of: photoreactivity parameters (direct photolysis quantum yield and second-order reaction rate constants with transient species, namely  OH, CO3(-) , (1)O2 and the triplet states of chromophoric dissolved organic matter, (3)CDOM*), water chemistry (nitrate, nitrite, bicarbonate, carbonate, bromide and dissolved organic carbon, DOC), and water depth (more specifically, the optical path length of sunlight in water).	Water	348-353	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	4-8
24356583-1	2014	The APEX software predicts the photochemical transformation kinetics of xenobiotics in surface waters as a function of: photoreactivity parameters (direct photolysis quantum yield and second-order reaction rate constants with transient species, namely  OH, CO3(-) , (1)O2 and the triplet states of chromophoric dissolved organic matter, (3)CDOM*), water chemistry (nitrate, nitrite, bicarbonate, carbonate, bromide and dissolved organic carbon, DOC), and water depth (more specifically, the optical path length of sunlight in water).	Water	348-353	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	4-8
24550514-0	2014	Dissociation of the trimeric gp41 ectodomain at the lipid-water interface suggests an active role in HIV-1 Env-mediated membrane fusion.	Water	58-63	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	107-110
24499396-6	2014	For births planned in FMUs, immersion in water was associated with a lower risk of intrapartum caesarean section (RR 0.61; 95% CI 0.44-0.84) and a higher chance of a straightforward vaginal birth (RR 1.09; 95% CI 1.04-1.15).	Water	41-46	ribonucleotide reductase catalytic subunit M1	Homo sapiens	197-201
23919619-11	2014	Thus, the Ero1alpha/GPx7/PDI triad generates two disulfide bonds and two H2O molecules at the expense of a single O2 molecule.	Water	73-76	glutathione peroxidase 7	Homo sapiens	20-24
23919619-11	2014	Thus, the Ero1alpha/GPx7/PDI triad generates two disulfide bonds and two H2O molecules at the expense of a single O2 molecule.	Water	73-76	prolyl 4-hydroxylase subunit beta	Homo sapiens	25-28
24176888-1	2014	We describe here the synthesis, characterization, bioconjugation, and application of water-soluble thioglycolic acid TGA-capped CdTe/CdS quantum dots (TGA-QDs) for targeted cellular imaging.	Water	85-90	T-box transcription factor 1	Homo sapiens	117-120
24176888-1	2014	We describe here the synthesis, characterization, bioconjugation, and application of water-soluble thioglycolic acid TGA-capped CdTe/CdS quantum dots (TGA-QDs) for targeted cellular imaging.	Water	85-90	T-box transcription factor 1	Homo sapiens	151-154
23625137-1	2014	PURPOSE: Aquaporin-1 (AQP1) is the predominant water channel in the heart, linked to cardiovascular homeostasis.	Water	47-52	aquaporin 1	Rattus norvegicus	9-20
23625137-1	2014	PURPOSE: Aquaporin-1 (AQP1) is the predominant water channel in the heart, linked to cardiovascular homeostasis.	Water	47-52	aquaporin 1	Rattus norvegicus	22-26
24081304-3	2014	We found that water maze training downregulated STAT1 expression in the rat hippocampal CA1 area, and spatial learning and memory function was enhanced in Stat1-knockout mice.	Water	14-19	signal transducer and activator of transcription 1	Rattus norvegicus	48-53
24081304-3	2014	We found that water maze training downregulated STAT1 expression in the rat hippocampal CA1 area, and spatial learning and memory function was enhanced in Stat1-knockout mice.	Water	14-19	signal transducer and activator of transcription 1	Rattus norvegicus	155-160
23553997-5	2014	Exposing the cells to 1600 microg/ml of the water fraction resulted in several gene changes that may also be beneficial in the treatment of colon cancer: NME4, TEK, and THBS1.	Water	44-49	TEK receptor tyrosine kinase	Homo sapiens	160-163
24369906-6	2014	In vivo, Mb apparently forms a natural electrostatic complex with cytochrome b5 (cyt-b5) through the "dynamic" (loose) docking pattern, allowing for a slow ET that is intrinsically coupled to the water"s removal from the "defective" heme iron (altogether shaping the biological repair mechanism for Mb"s "met" form).	Water	196-201	cytochrome b5 type A	Equus caballus	66-79
24369906-6	2014	In vivo, Mb apparently forms a natural electrostatic complex with cytochrome b5 (cyt-b5) through the "dynamic" (loose) docking pattern, allowing for a slow ET that is intrinsically coupled to the water"s removal from the "defective" heme iron (altogether shaping the biological repair mechanism for Mb"s "met" form).	Water	196-201	cytochrome b5 type A	Equus caballus	81-87
24285389-3	2014	METHODS: Water equilibrated with air under controlled conditions was filled into copper capillaries to produce small (about 1 muL) air-equilibrated water samples (so-called muAEWs).	Water	9-14	tripartite motif containing 37	Homo sapiens	126-129
24285389-3	2014	METHODS: Water equilibrated with air under controlled conditions was filled into copper capillaries to produce small (about 1 muL) air-equilibrated water samples (so-called muAEWs).	Water	148-153	tripartite motif containing 37	Homo sapiens	126-129
24196830-10	2014	Collectively, the current data demonstrate that metformin given in the drinking water effectively inhibited skin tumor promotion in both overweight and obese mice and that the mechanism involves activation of epidermal AMPK and attenuated signaling downstream of mTORC1.	Water	80-85	CREB regulated transcription coactivator 1	Mus musculus	263-269
24638840-3	2014	Several investigations recently reported that sulfidation of AgNPs to Ag2S was the predominant mechanism controlling the fate of AgNP in soil-water environments.	Water	142-147	angiotensin II receptor type 1	Homo sapiens	70-74
24705861-5	2014	Also, significantly increased by the binge alcohol treatments was aquaporin-4 (AQP4), a water channel enriched in astrocytes that, when augmented, may trigger brain (esp.	Water	88-93	protein tyrosine phosphatase, receptor type, V	Rattus norvegicus	166-169
25072708-3	2014	Forty-eight hours after infection of the hepatocytes with recombinant StarD1 adenovirus, a water-soluble oxysterol product was isolated and purified by chemical extraction and reverse-phase HPLC.	Water	91-96	steroidogenic acute regulatory protein	Homo sapiens	70-76
24815422-4	2014	bFGF-loaded NP (bFGF-NP) were prepared with Poloxamer 188-grafted heparin copolymer using water-in-water technique, and the morphology, encapsulation efficiency, and bioactivity of bFGF-NP were studied.	Water	90-95	fibroblast growth factor 2	Rattus norvegicus	0-4
24815422-4	2014	bFGF-loaded NP (bFGF-NP) were prepared with Poloxamer 188-grafted heparin copolymer using water-in-water technique, and the morphology, encapsulation efficiency, and bioactivity of bFGF-NP were studied.	Water	99-104	fibroblast growth factor 2	Rattus norvegicus	0-4
25020237-6	2014	The predicted densities for neat ionic liquids and the [P6,6,6,14][BOB] sample, with a water content of approximately 2.3-2.5 wt %, are in excellent agreement with available experimental data.	Water	87-92	G protein-coupled receptor 15	Homo sapiens	67-70
24911289-5	2014	Here, we present QM/MM MD simulations of the cyclization step involved in the formation of G[8-5m]T from the guanine-thymine (GpT) DM in water, with the aim of comparing our results to our previous investigation of the same reaction in DNA ( Garrec , J. , Patel , C. , Rothlisberger , U. , and Dumont , E. ( 2012 ) J.	Water	137-142	glutamic--pyruvic transaminase	Homo sapiens	126-129
24911289-12	2014	This effect is due to the Watson-Crick H-bonds, which are absent in the {GpT+water} system and restrain the relative positioning of the reactive nucleobases in DNA.	Water	77-82	glutamic--pyruvic transaminase	Homo sapiens	73-76
25015569-3	2014	The use of albumin as a complexing agent for a hydrophobic drug is expected to improve the water solubility and consequently their bioavailability.This study investigated the antitumor activity of a novel complex between albumin and 4-HPR in a mouse model of human lung cancer and focuses on role and mechanism of Cav-1 mainly involved in regulating cancer and ACSVL3 mainly connected with tumor growth.	Water	91-96	albumin	Mus musculus	11-18
25015569-3	2014	The use of albumin as a complexing agent for a hydrophobic drug is expected to improve the water solubility and consequently their bioavailability.This study investigated the antitumor activity of a novel complex between albumin and 4-HPR in a mouse model of human lung cancer and focuses on role and mechanism of Cav-1 mainly involved in regulating cancer and ACSVL3 mainly connected with tumor growth.	Water	91-96	albumin	Mus musculus	221-228
25101170-0	2014	Synthesis, modification and graft polymerization of magnetic nano particles for PAH removal in contaminated water.	Water	108-113	phenylalanine hydroxylase	Homo sapiens	80-83
24992646-5	2014	Particulate backscattering, bbp, demonstrated multiple peaks throughout the water column, including from phytoplankton, deep scattering layers, and resuspension.	Water	76-81	transmembrane protein 158	Homo sapiens	28-31
24888581-4	2014	Here, we report measurements of water density and diffusion dynamics in the vicinity of a spin label attached to a cysteine in the Tyr71   Cys GroES mutant obtained using two magnetic resonance techniques: electron-spin echo envelope modulation and Overhauser dynamic nuclear polarization.	Water	32-37	heat shock protein family E (Hsp10) member 1	Homo sapiens	143-148
24888581-5	2014	Residue 71 in GroES is fully exposed to bulk water in free GroES and to confined water within the cavity of the GroEL-GroES complex.	Water	45-50	heat shock protein family E (Hsp10) member 1	Homo sapiens	14-19
24888581-5	2014	Residue 71 in GroES is fully exposed to bulk water in free GroES and to confined water within the cavity of the GroEL-GroES complex.	Water	45-50	heat shock protein family E (Hsp10) member 1	Homo sapiens	59-64
24888581-5	2014	Residue 71 in GroES is fully exposed to bulk water in free GroES and to confined water within the cavity of the GroEL-GroES complex.	Water	45-50	heat shock protein family E (Hsp10) member 1	Homo sapiens	59-64
24888581-5	2014	Residue 71 in GroES is fully exposed to bulk water in free GroES and to confined water within the cavity of the GroEL-GroES complex.	Water	81-86	heat shock protein family E (Hsp10) member 1	Homo sapiens	14-19
24888581-7	2014	Interestingly, the diffusion dynamics of water near the GroES surface are found to be unusually fast relative to other protein surfaces studied.	Water	41-46	heat shock protein family E (Hsp10) member 1	Homo sapiens	56-61
24833134-4	2014	P2X double knockout and wild-type mice were given 24-h choice tests (vs. water) with ascending concentrations of Polycose and Intralipid.	Water	73-78	purinergic receptor P2X, ligand-gated ion channel, 1	Mus musculus	0-3
24434597-2	2014	Comparative studies over the last six decades have revealed that a conserved function for prolactin across vertebrates is the regulation of ion and water transport in a variety of tissues including those responsible for whole-organism ion homeostasis.	Water	148-153	prolactin	Danio rerio	90-99
24434597-3	2014	In teleost fishes, prolactin was identified as the "freshwater-adapting hormone", promoting ion-conserving and water-secreting processes by acting on the gill, kidney, gut and urinary bladder.	Water	57-62	prolactin	Danio rerio	19-28
24265116-3	2014	In a Matrigel invasion assay, IL-18-induced migration of primary mouse CF was dependent on both IKK/NF-kappaB- and JNK/AP-1-mediated MMP9 induction and Sp1-mediated RECK suppression, mechanisms that required Nox4-dependent H(2)O(2) generation.	Water	223-228	interleukin 18	Mus musculus	30-35
25034304-0	2014	Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10.	Water	85-90	presenilin 1	Homo sapiens	53-65
24836941-2	2014	Ti-MOF-Ru(tpy)2 promotes photocatalytic hydrogen production from water containing a sacrificial electron donor under visible-light irradiation up to 620 nm.	Water	65-70	lysine acetyltransferase 8	Homo sapiens	3-6
24863918-3	2014	Here, we show that water-suspended fullerene C60 nanocrystals (nano-C60) interact with and modulate the function of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), a multimeric intracellular serine/threonine kinase central to Ca(2+) signal transduction, in a fashion that rivals the well-documented interaction between the NMDA (N-methyl-d-aspartate) receptor subunit NR2B protein and CaMKII.	Water	19-24	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	120-165
24863918-3	2014	Here, we show that water-suspended fullerene C60 nanocrystals (nano-C60) interact with and modulate the function of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), a multimeric intracellular serine/threonine kinase central to Ca(2+) signal transduction, in a fashion that rivals the well-documented interaction between the NMDA (N-methyl-d-aspartate) receptor subunit NR2B protein and CaMKII.	Water	19-24	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	167-173
24863918-3	2014	Here, we show that water-suspended fullerene C60 nanocrystals (nano-C60) interact with and modulate the function of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), a multimeric intracellular serine/threonine kinase central to Ca(2+) signal transduction, in a fashion that rivals the well-documented interaction between the NMDA (N-methyl-d-aspartate) receptor subunit NR2B protein and CaMKII.	Water	19-24	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	397-403
26580766-6	2014	Based on results for the lowest excitation energies computed with the HSE hybrid functional and a Davidson diagonalization scheme, the CTTS transition has been found 0.6 eV below the first absorption band of liquid water.	Water	215-220	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	70-73
24898794-8	2014	CD73 activity in these rats was increased by 46% with the 28-day GTA treatment compared to the water-treated rats.	Water	95-100	5' nucleotidase, ecto	Rattus norvegicus	0-4
24508576-0	2014	Using the reversible inhibition of gastric lipase by Orlistat for investigating simultaneously lipase adsorption and substrate hydrolysis at the lipid-water interface.	Water	151-156	pancreatic lipase related protein 1	Canis lupus familiaris	43-49
24636993-0	2014	GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts.	Water	21-26	GATA binding protein 2	Mus musculus	0-5
24648513-4	2014	Substitution of Rheb Gly-63 with alanine impaired both intrinsic and TSC2 GTPase-activating protein (GAP)-mediated GTP hydrolysis by displacing the hydrolytic water molecule, whereas introduction of a bulkier valine side chain selectively blocked GTP binding by steric occlusion of the gamma-phosphate.	Water	159-164	Ras homolog, mTORC1 binding	Homo sapiens	16-20
24518984-9	2014	The results also implicate that intestinal AhR might act not only as a sensor for xenobiotics in diet and water but also for commensal bacterial activity because DHNA is a precursor of vitamin K2 produced by vitamin K2-synthesizing commensal bacteria as well as propionic bacteria.	Water	106-111	aryl hydrocarbon receptor	Homo sapiens	43-46
24021664-6	2014	Overexpression of IL-27p28 in vivo ameliorated EAU as well as EAE pathology and reduced tissue infiltration by Th1 and Th17 cells in a disease prevention, as well as in a disease reversal protocol.	Water	47-50	interleukin 27	Homo sapiens	18-26
24492487-9	2014	Some progestogens can mitigate estradiol effects on water and sodium retention through competition with aldosterone for the mineralocorticoid receptor and attenuating aldosterone-mediated sodium retention in the distal tubule.	Water	52-57	nuclear receptor subfamily 3 group C member 2	Homo sapiens	124-150
24679819-1	2014	In this work, the Li-rich oxide Li1.23Ni0.09Co0.12Mn0.56O2 was synthesized through a facile route called aqueous solution-evaporation route that is simple and without waste water.	Water	173-178	transglutaminase 1	Homo sapiens	32-35
24599952-10	2014	The structure reported here is not only the first of any bacterial amidase in which both the PGN component and the water molecule that carries out the nucleophilic attack on the carbonyl carbon of the scissile bond are present; it is also the first peptidoglycan amidase complex structure of an important human pathogen.	Water	115-120	AT695_RS13185	Staphylococcus aureus	67-74
24599952-10	2014	The structure reported here is not only the first of any bacterial amidase in which both the PGN component and the water molecule that carries out the nucleophilic attack on the carbonyl carbon of the scissile bond are present; it is also the first peptidoglycan amidase complex structure of an important human pathogen.	Water	115-120	AT695_RS13185	Staphylococcus aureus	263-270
24709946-2	2014	In dat-1(ok157) animals, DA is not taken back up presynaptically but instead reaches extrasynpatic sites, where it activates the dopamine receptor DOP-3 on choligeneric motor neurons and causes animals to become paralyzed in water.	Water	225-230	Dopamine receptor 3	Caenorhabditis elegans	147-152
24882978-9	2014	A substantial reduction was observed in the lesional mRNA levels of IL-17A and IL-23 in the mineral water group.	Water	100-105	interleukin 23, alpha subunit p19	Mus musculus	79-84
24374967-4	2014	Administration of HMGB1 antagonists inhibited severity of EAU significantly via mechanisms that include inhibition of IRBP-specific T cell proliferation and their IFN-gamma and IL-17 production.	Water	58-61	high mobility group box 1	Mus musculus	18-23
24663151-5	2014	Remarkably, this water network and Na+ ion is highly conserved between beta1AR and the adenosine A2A receptor (rmsd of 0.3 A), despite an overall rmsd of 2.4 A for all Calpha atoms and only 23% amino acid identity in the transmembrane regions.	Water	17-22	adrenoceptor beta 1	Homo sapiens	71-78
24663151-7	2014	Mutation of amino acid side chains that are involved in the co-ordination of either Na+ or water molecules in the network decreases the stability of beta1AR by 5-10 C. The data suggest that the intramembrane Na+ and associated water network stabilise the ligand-free state of beta1AR, but still permits the receptor to form the activated state which involves the collapse of the Na+ binding pocket on agonist binding.	Water	91-96	adrenoceptor beta 1	Homo sapiens	149-156
24663151-7	2014	Mutation of amino acid side chains that are involved in the co-ordination of either Na+ or water molecules in the network decreases the stability of beta1AR by 5-10 C. The data suggest that the intramembrane Na+ and associated water network stabilise the ligand-free state of beta1AR, but still permits the receptor to form the activated state which involves the collapse of the Na+ binding pocket on agonist binding.	Water	91-96	adrenoceptor beta 1	Homo sapiens	276-283
24663151-7	2014	Mutation of amino acid side chains that are involved in the co-ordination of either Na+ or water molecules in the network decreases the stability of beta1AR by 5-10 C. The data suggest that the intramembrane Na+ and associated water network stabilise the ligand-free state of beta1AR, but still permits the receptor to form the activated state which involves the collapse of the Na+ binding pocket on agonist binding.	Water	227-232	adrenoceptor beta 1	Homo sapiens	149-156
24663151-7	2014	Mutation of amino acid side chains that are involved in the co-ordination of either Na+ or water molecules in the network decreases the stability of beta1AR by 5-10 C. The data suggest that the intramembrane Na+ and associated water network stabilise the ligand-free state of beta1AR, but still permits the receptor to form the activated state which involves the collapse of the Na+ binding pocket on agonist binding.	Water	227-232	adrenoceptor beta 1	Homo sapiens	276-283
24440342-2	2014	Here, male mice were exposed to 50 mug/kg BW/day CYP, 100 mug/kg BW/day ATZ or 1 mug/kg BW/day EE2 supplied in their drinking water for 20 weeks.	Water	126-131	esterase 3	Mus musculus	95-98
24485149-2	2014	Relative to EAE mice that received vehicle (water, 10 ml/kg/day), oral administration of AF4 (25mg/kg/day) beginning 24h after the onset of clinical signs reduced disease severity from days 19-31 post-immunization.	Water	44-49	immunoglobulin kappa variable 4-80	Mus musculus	89-92
24269730-4	2014	We report that a chronic treatment with fluoxetine administered in the drinking water normalizes GABA release and promotes recovery of spatial memory abilities, spatial working memory for alternation, and hippocampal synaptic plasticity in adult Ts65Dn mice.	Water	80-85	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	246-252
24504533-10	2014	Data on the occurrence of alien species in different water environments play an important role in actions which are taken to prevent new invasions and spread of non-native species as well as to reduce future impacts of invaders.	Water	53-58	COP9 signalosome subunit 2	Homo sapiens	26-31
24449516-1	2014	Looking for water-soluble inhibitors of matrix metalloproteinase-2 (MMP-2 or gelatinase A), we have previously reported compound 1, a potent MMP-2 inhibitor with a promising selectivity over the structurally homologous MMP-9 (gelatinase B).	Water	12-17	matrix metallopeptidase 2	Homo sapiens	40-66
24449516-1	2014	Looking for water-soluble inhibitors of matrix metalloproteinase-2 (MMP-2 or gelatinase A), we have previously reported compound 1, a potent MMP-2 inhibitor with a promising selectivity over the structurally homologous MMP-9 (gelatinase B).	Water	12-17	matrix metallopeptidase 2	Homo sapiens	68-73
24496471-2	2014	The metal iodides (MgI2, AlI3, ZnI2, FeI2) were synthesized directly from metal and iodine powder with water as a catalyzer.	Water	103-108	adhesion molecule with Ig like domain 3	Homo sapiens	25-29
23826797-1	2014	Four different aquaporins (AQP1, 2, 5 and 9), integral membrane water channels that facilitate rapid passive movement of water, were immuno-localized in the excurrent ducts collected from sexually mature cats during orchiectomy.	Water	64-69	aquaporin-1	Felis catus	27-43
24498108-6	2014	In this study we initially conducted in-vitro investigations of the new cationic water-soluble photo sensitizer tetrahydroporphyrin-tetratosylat (THPTS) regarding its photodynamic effect on human Rb-1 and Y79 retinoblastoma cells.	Water	81-86	RB transcriptional corepressor 1	Homo sapiens	196-200
24318650-7	2014	DF-LMP2 will be used in future studies because its overall performance in describing the relative binding energies and the geometrical parameters of Cl(-)(H2O)n (n = 1-4) was outstanding in this study.	Water	155-158	proteasome 20S subunit beta 9	Homo sapiens	3-7
24359273-5	2014	Under the same conditions, the enzymes arginase and agmatinase accelerate substrate hydrolysis 4 x 10(14)-fold and 6 x 10(12)-fold, respectively, by mechanisms that appear to involve metal-mediated water attack.	Water	198-203	agmatinase	Homo sapiens	52-62
24523642-0	2014	Use of heavy water (D2O) in developing thermostable recombinant p26 protein based enzyme-linked immunosorbent assay for serodiagnosis of equine infectious anemia virus infection.	Water	13-18	transmembrane p24 trafficking protein 3	Homo sapiens	64-67
24523642-2	2014	In view of the above observations, effect of heavy water on in situ thermostabilization of recombinant p26 protein on enzyme-linked immunosorbent assay (ELISA) for serodiagnosis of equine infectious anemia virus (EIAV) infection was investigated in the present study.	Water	51-56	transmembrane p24 trafficking protein 3	Homo sapiens	103-106
24095673-9	2014	Strikingly, HO2 radicals were an order of magnitude more concentrated in the headgroups region than in water, implying a large shift in the acid-base equilibrium between HO2 and O2(-).	Water	103-108	heme oxygenase 2	Homo sapiens	12-15
24672546-4	2014	The ingestion of the mineral water (rich in sodium bicarbonate and with higher potassium, calcium, and magnesium content than the tap water used as control) reduced/prevented not only the fructose-induced increase of heart rate, plasma triacylglycerols, insulin and leptin levels, hepatic catalase activity, and organ weight to body weight ratios (for liver and both kidneys) but also the decrease of hepatic glutathione peroxidase activity and oxidized glutathione content.	Water	29-34	leptin	Rattus norvegicus	266-272
24261925-14	2014	CONCLUSION: Changes in the diffusion of water within the lumbar intervertebral discs at the L1-2, L2-3, and L5-S1 levels appear to be related to differences in within-session pain reports following a single treatment of spinal manipulative therapy.	Water	40-45	LINE1 retrotransposable element 1	Homo sapiens	92-96
25302337-1	2014	Recently, the frequent seasonal drought in Southwest China has brought considerable concerns and continuous heated arguments on the "water pump" viewpoint (i.e., the water demand from Hevea spp.	Water	133-138	histocompatibility minor 13	Homo sapiens	190-193
24004749-1	2014	BACKGROUND: The Mark 3 (M3) water power pump is an integral piece of wildfire fighting equipment.	Water	28-33	microtubule affinity regulating kinase 3	Homo sapiens	16-22
24004749-1	2014	BACKGROUND: The Mark 3 (M3) water power pump is an integral piece of wildfire fighting equipment.	Water	28-33	microtubule affinity regulating kinase 3	Homo sapiens	24-26
24316079-5	2013	Similarly to ACBP(-/-) mice, K14-ACBP(-/-) mice exhibit an increased transepidermal water loss, and we show that the hepatic phenotype is caused specifically by the epidermal barrier defect, which leads to increased lipolysis in white adipose tissue.	Water	84-89	diazepam binding inhibitor	Mus musculus	33-37
26120456-8	2013	At the same time, basic science discovered the water channel aquaporin-1 (AQP-1), and a few years later, studies in transgenic mice confirmed that AQP-1 was the ultrasmall pore.	Water	47-52	aquaporin 1	Mus musculus	74-79
24444133-1	2013	OBJECTIVE: During 2009-2011, Pike County, Kentucky, experienced a series of severe weather events that resulted in property damage, insufficient potable water, and need for temporary shelters.	Water	153-158	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	Homo sapiens	29-33
23249140-1	2013	Catalase is an important antioxidant enzyme that catalyzes the disproportionation of H2O2 into harmless water and molecular oxygen.	Water	104-109	catalase	Bos taurus	0-8
24269248-7	2014	n-Butanol soluble fraction of the water extract of Chinese toon fruit reduced the levels of nitrate, nitrite, lipid peroxidation, cyclooxygenase-1, thromboxane in post-ischemic brain.	Water	34-39	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	130-146
24844894-2	2014	The total PAH concentrations (sum of the concentrations of 17 individual PAH compounds) in water samples ranged from 67 to 96 ng L(-1), which were predominated by two- and three-ring PAHs.	Water	91-96	phenylalanine hydroxylase	Homo sapiens	10-13
24844894-2	2014	The total PAH concentrations (sum of the concentrations of 17 individual PAH compounds) in water samples ranged from 67 to 96 ng L(-1), which were predominated by two- and three-ring PAHs.	Water	91-96	phenylalanine hydroxylase	Homo sapiens	73-76
23934013-3	2014	It was found that water shortage resulted in an increase of membrane injury, lipoxygenase (LOX) activity, lipid peroxidation and proline concentration in cucumber roots during progressive dehydration.	Water	18-23	probable linoleate 9S-lipoxygenase 5-like	Cucumis sativus	77-89
23934013-3	2014	It was found that water shortage resulted in an increase of membrane injury, lipoxygenase (LOX) activity, lipid peroxidation and proline concentration in cucumber roots during progressive dehydration.	Water	18-23	probable linoleate 9S-lipoxygenase 5-like	Cucumis sativus	91-94
27450342-3	2016	Further kinetic analysis reveals that the oxidation of individual PAH in the biphasic tar/water system follows the first-order kinetics, and individual PAH oxidation rate is primary determined by the mass transfer coefficients, tar/water interfacial areas, the aqueous solubility of individual PAH and its concentration in coal tar.	Water	232-237	phenylalanine hydroxylase	Homo sapiens	152-155
25416390-4	2014	Use of CO as metabolic fuel for microbes relies on enzymes like carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS), which catalyze conversions resembling processes that eventually initiated the dawn of life.CODHs catalyze the (reversible) oxidation of CO with water to CO2 and come in two different flavors with unprecedented active site architectures.	Water	276-281	acyl-CoA synthetase short chain family member 2	Homo sapiens	105-124
24028220-2	2013	In previous studies, central administration of NPW during the light phase increased food and water intake and elevated prolactin and corticosterone levels in conscious, unrestrained male rats.	Water	93-98	neuropeptide W	Rattus norvegicus	47-50
27450342-3	2016	Further kinetic analysis reveals that the oxidation of individual PAH in the biphasic tar/water system follows the first-order kinetics, and individual PAH oxidation rate is primary determined by the mass transfer coefficients, tar/water interfacial areas, the aqueous solubility of individual PAH and its concentration in coal tar.	Water	232-237	phenylalanine hydroxylase	Homo sapiens	152-155
25416390-4	2014	Use of CO as metabolic fuel for microbes relies on enzymes like carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS), which catalyze conversions resembling processes that eventually initiated the dawn of life.CODHs catalyze the (reversible) oxidation of CO with water to CO2 and come in two different flavors with unprecedented active site architectures.	Water	276-281	acyl-CoA synthetase short chain family member 2	Homo sapiens	126-129
27751850-5	2016	We present a detailed picture of interactions between BECa and NADH, including bound water molecules located near the C1"-N glycosidic bond of NADH and the catalytically important ADP-ribosylating turn-turn (ARTT) loop.	Water	85-90	becA	Clostridium perfringens	54-58
25729239-4	2014	As a functional example, the Parathyroid Hormone-related Protein (PTHrP) signaling duplicated during the Phanerozoic water-land transition.	Water	117-122	parathyroid hormone like hormone	Homo sapiens	29-64
25729239-4	2014	As a functional example, the Parathyroid Hormone-related Protein (PTHrP) signaling duplicated during the Phanerozoic water-land transition.	Water	117-122	parathyroid hormone like hormone	Homo sapiens	66-71
24289479-10	2013	RESULTS: Expression of Tim-3 increased early in mouse peri-hematomal brain tissue after autologous blood injection, peaked at day 1, and was positively correlated with the concentrations of TNF-alpha, IL-1beta, and brain water content.	Water	221-226	hepatitis A virus cellular receptor 2	Mus musculus	23-28
27759379-4	2016	In the present work, we refine the interactions of Mg2+ with water, Cl- ions, and nucleic acid moieties using a polarizable force field based on the classical Drude oscillator model.	Water	61-66	mucin 7, secreted	Homo sapiens	51-54
24241823-7	2013	Moreover, we found that the cavity of the SCP2 domains is distinctly formed by carbon atoms, containing neither organized water nor rigid polar interactions with the ligand.	Water	122-127	sterol carrier protein 2	Homo sapiens	42-46
24173210-2	2013	The number of water molecules required to induce folding increases monotonically with the chain length and is n = 9-12, n = 13, and n = 18-19 for succinate (m = 2), adipate (m = 4), and sebacate (m = 8), respectively.	Water	14-19	prion locus lncRNA, testis expressed	Homo sapiens	196-201
27759379-6	2016	Notable is the direct modeling of steric repulsion between the water Drude oscillators and Mg2+ to treat the Pauli exclusion effects associated with overlap of the electron clouds of water molecules in the first hydration shell around Mg2+.	Water	183-188	mucin 7, secreted	Homo sapiens	91-94
24320225-2	2013	For example, X-ray diffraction studies demonstrate that [kappa(4)-Tptm]ZnF forms an adduct with water in which hydrogen bonding between the fluoride ligands and water molecules serves to link pairs of [kappa(4)-Tptm]ZnF molecules with a [F   (H-O-H)2   F] motif.	Water	96-101	zinc finger protein 763	Homo sapiens	71-74
24320225-2	2013	For example, X-ray diffraction studies demonstrate that [kappa(4)-Tptm]ZnF forms an adduct with water in which hydrogen bonding between the fluoride ligands and water molecules serves to link pairs of [kappa(4)-Tptm]ZnF molecules with a [F   (H-O-H)2   F] motif.	Water	96-101	zinc finger protein 763	Homo sapiens	216-219
24320225-2	2013	For example, X-ray diffraction studies demonstrate that [kappa(4)-Tptm]ZnF forms an adduct with water in which hydrogen bonding between the fluoride ligands and water molecules serves to link pairs of [kappa(4)-Tptm]ZnF molecules with a [F   (H-O-H)2   F] motif.	Water	161-166	zinc finger protein 763	Homo sapiens	71-74
24436993-10	2013	MMP-2 (P &lt; 0.05) and MMP-9 (P &lt; 0.01) levels were positively correlated with spinal cord water content.	Water	95-100	matrix metallopeptidase 2	Rattus norvegicus	0-5
26592300-4	2013	We find that experimentally observed water-binding sites on the surface of bovine chymosin can be identified quickly and accurately from the density distribution functions computed by molecular integral equation theory.	Water	37-42	chymosin	Bos taurus	82-90
24320404-9	2013	MD simulation of LAO in explicit water was performed for 1 mus, and the obtained trajectory of C(alpha) atoms in the backbone was analyzed by tICA.	Water	33-38	interleukin 4 induced 1	Homo sapiens	17-20
24224470-3	2013	Water-soluble Ag2S QDs were synthesized and conjugated with the CS-SNO compounds with the aid of ethylenediaminetetraacetic acid (EDTA).	Water	0-5	angiotensin II receptor type 1	Homo sapiens	14-18
24268144-4	2013	Lipid bilayer-inserted hIAPP trimers and tetramers orient inside DPPG at 60  relative to the membrane/water interface and lead to water permeation and Na(+) intrusion, consistent with ion-toxicity in islet beta-cells.	Water	102-107	islet amyloid polypeptide	Homo sapiens	23-28
24268144-4	2013	Lipid bilayer-inserted hIAPP trimers and tetramers orient inside DPPG at 60  relative to the membrane/water interface and lead to water permeation and Na(+) intrusion, consistent with ion-toxicity in islet beta-cells.	Water	130-135	islet amyloid polypeptide	Homo sapiens	23-28
24268144-5	2013	In particular, hIAPP trimers form a water-filled beta-sandwich that induce water permeability comparable with channel-forming proteins, such as aquaporins and gramicidin-A.	Water	36-41	islet amyloid polypeptide	Homo sapiens	15-20
24268144-5	2013	In particular, hIAPP trimers form a water-filled beta-sandwich that induce water permeability comparable with channel-forming proteins, such as aquaporins and gramicidin-A.	Water	75-80	islet amyloid polypeptide	Homo sapiens	15-20
24552061-7	2013	Six T&amp;O compounds (IPMP, IBMP, trans,cis-2,6-nonadienal, 2-methylbenzofuran, trans-2-decenal, and TCA) were effectively decreased in water treatment process (sedimentation and filtration) that is different from cis-3-hexenyl acetate, MIB and geosmin.	Water	137-142	suppressor of cytokine signaling 3	Homo sapiens	215-220
24054563-6	2013	In this study glycerol-water mixtures served as immersion liquids to obtain the refractive index of CaF2 at several discrete wavelengths in the spectral range 200-500 nm.	Water	23-28	CCR4-NOT transcription complex subunit 8	Homo sapiens	100-104
24147203-7	2013	Additionally, there is evidence that GLP-1 receptor agonists influence water and electrolyte balance.	Water	71-76	glucagon like peptide 1 receptor	Homo sapiens	37-51
24112444-0	2013	Does continuous endurance exercise in water elicit a higher release of ANP and BNP and a higher plasma concentration of FFAs in pre-obese and obese men than high intensity intermittent endurance exercise?	Water	38-43	natriuretic peptide B	Homo sapiens	79-82
24112444-13	2013	The aims of the study are to investigate (1) whether continuous endurance exercise or high intensity intermittent endurance exercise in water elicits both a higher release of ANP and BNP and a higher plasma concentration of glycerol and (2) to determine whether continuous endurance exercise in water or a high intensity intermittent endurance exercise in water would lead to a more pronounced short term (two hours) EPOC effect.	Water	136-141	natriuretic peptide B	Homo sapiens	183-186
24112444-14	2013	DISCUSSION: If our hypothesis would be confirmed, the most effective exercise protocol based on the combined effects of high intensity endurance exercise and water immersion on ANP and BNP release and glycerol plasma concentrations can be identified.	Water	158-163	natriuretic peptide B	Homo sapiens	185-188
23057598-5	2013	Bound water zone is predominant at elevated surfactant/oil ratios, while as the surfactant/oil ratio decreases, DSC reveals the presence of free water.	Water	145-150	desmocollin 3	Homo sapiens	112-115
23760740-2	2013	We applied NMR spectroscopy to study the partitioning of a water-soluble bile acid binding protein (BABP), belonging to the FABP family, between its free and lipid-vesicle-bound states.	Water	59-64	aldo-keto reductase family 1 member C2	Homo sapiens	73-98
23760740-2	2013	We applied NMR spectroscopy to study the partitioning of a water-soluble bile acid binding protein (BABP), belonging to the FABP family, between its free and lipid-vesicle-bound states.	Water	59-64	aldo-keto reductase family 1 member C2	Homo sapiens	100-104
24071712-7	2013	hIAPP forms pentameric aggregates with the hydrophobic residues facing the membrane core and stabilizing water-conducting pores.	Water	105-110	islet amyloid polypeptide	Homo sapiens	0-5
23702000-0	2013	Systemically administered gp100 encoding DNA vaccine for melanoma using water-in-oil-in-water multiple emulsion delivery systems.	Water	72-77	premelanosome protein	Mus musculus	26-31
23702000-0	2013	Systemically administered gp100 encoding DNA vaccine for melanoma using water-in-oil-in-water multiple emulsion delivery systems.	Water	88-93	premelanosome protein	Mus musculus	26-31
23702000-1	2013	The purpose of this study was to develop a water-in-oil-in-water (W/O/W) multiple emulsions-based vaccine delivery system for plasmid DNA encoding the gp100 peptide antigen for melanoma immunotherapy.	Water	43-48	premelanosome protein	Mus musculus	151-156
23702000-1	2013	The purpose of this study was to develop a water-in-oil-in-water (W/O/W) multiple emulsions-based vaccine delivery system for plasmid DNA encoding the gp100 peptide antigen for melanoma immunotherapy.	Water	59-64	premelanosome protein	Mus musculus	151-156
23694847-8	2013	Duplex-oil films of oxidized mineral oil/mucin (MOx/BSM), human meibum (HM), and bovine meibum (BM) reduce water evaporation by a dissolution-diffusion mechanism, as confirmed by agreement between measurement and theory.	Water	107-112	LOC100508689	Homo sapiens	41-46
23856493-3	2013	Intracerebroventricular infusion of Ang II at 1.0, 2.5, and 12.5 ng/min for 2 weeks caused dose-related increases in water intake, Ang II concentration in the cerebrospinal fluid, and blood pressure.	Water	117-122	angiogenin	Homo sapiens	36-39
23845376-0	2013	Re: glucocorticoid mediates water avoidance stress-sensitized colon-bladder cross-talk via RSK2/PSD-95/NR2B in rats.	Water	28-33	discs large MAGUK scaffold protein 4	Rattus norvegicus	96-102
23673351-7	2013	Functional assays (using heterologous expression in Xenopus laevis oocytes) of ZmTIP2;2 and ZmPIP2;8 confirmed that these aquaporins demonstrate water channel capacity.	Water	145-150	aquaporin TIP2-2	Zea mays	79-87
24187844-4	2013	In addition, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) was used to study the protein conformation and the water content of stratum corneum, and the result suggested that ACS can change the orderly arrangement of the molecules in the stratum corneum, making the stack structure of keratin become loose.	Water	143-148	acyl-CoA synthetase short chain family member 2	Homo sapiens	207-210
24187844-5	2013	And ACS can increase the water content of the stratum corneurn.	Water	25-30	acyl-CoA synthetase short chain family member 2	Homo sapiens	4-7
24558828-1	2013	OBJECTIVE: To investigate the effects of Drynariae Rhizoma water-extraction on the ability of osteogenic differentiation and the expression of TGF-beta1 and BMP-2 in inducing mesenchymal stem cells (MSCs) differentiation into osteoblast and its mechanism.	Water	59-64	bone morphogenetic protein 2	Homo sapiens	157-162
24558828-6	2013	The classic group, Drynariae Rhizoma water-extraction group and Drynariae Rhizoma water-extraction + classic group could promote the osteogenic differentiation of MSCs and increase the expression of TGF-beta1 and BMP-2.	Water	82-87	bone morphogenetic protein 2	Homo sapiens	213-218
24558828-8	2013	Epimedium water-extraction can improve the differentiation of MSC into osteoblast and its mechanism may be related to increasing the expression of TGF-beta1 and BMP-2.	Water	10-15	bone morphogenetic protein 2	Homo sapiens	161-166
23769982-10	2013	On the other hand, the highest inhibitions of beta-hexosaminidase release were recorded for the ethanol extract of leaves with IC50 value of 6.89 microg/ml followed by the water extract of the seeds and leaves with IC50 value of 78.32 and 88.44 microg/ml, respectively.	Water	172-177	O-GlcNAcase	Mus musculus	46-65
23935921-13	2013	The present study suggests that pharmacological activation of AMPK effectively reduces CTX mediated increases in intestinal chloride secretion, which is a key factor for intestinal water accumulation.	Water	181-186	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	62-66
23697579-2	2013	Here we describe the development of a polymeric NP, termed M-NP, comprising poly(D,L-lactic-co-glycolic acid)-block-poly(ethylene glycol) (PLGA-PEG), stabilized with poly(vinyl alcohol) (PVA), and loaded with a water-soluble platinum(IV) [Pt(IV)] prodrug, mitaplatin.	Water	211-216	modifier of Niemann Pick type C1	Mus musculus	59-63
23883429-0	2013	One-step synthesis of highly efficient three-dimensional Cd1-xZnxS photocatalysts for visible light photocatalytic water splitting.	Water	115-120	CD1c molecule	Homo sapiens	57-60
23875003-4	2013	3xTg-AD mice fed 0.23% w/v lipoic acid in drinking water for 4 weeks showed an insulin mimetic effect that consisted of increased brain glucose uptake, activation of the insulin receptor substrate and of the PI3K/Akt signaling pathway.	Water	51-56	insulin receptor	Homo sapiens	170-186
23707334-1	2013	ETHNOPHARMACOLOGICAL RELEVANCE: Salvianolic acid A (SAA) is one of the main water-soluble components isolated from Salvia miltiorrhiza Bunge.	Water	76-81	serum amyloid A1	Canis lupus familiaris	52-55
23631473-5	2013	The addition of water accelerates the rate of catalysis by facilitating deprotonation of the hydrogen addition product before oxidation, especially for the larger bases NEt3 and t-BuNH2.	Water	16-21	tetraspanin 2	Homo sapiens	169-173
23325502-9	2013	PAH dissipation through water leaching was limited and did not present a significant risk for the environment.	Water	24-29	phenylalanine hydroxylase	Homo sapiens	0-3
23325502-10	2013	This PAH water concentration appeared however as a good indicator of overall dissipation rate, thereby illustrating the importance of pollutant availability in predicting its degradation potential.	Water	9-14	phenylalanine hydroxylase	Homo sapiens	5-8
23624112-8	2013	Thus, the increased Lp(c) and transcription levels of TaPIP1;2 and TaPIP2;5 in wheat roots provides insight into the mechanisms underlying enhanced root water uptake with increasing chromosome ploidy during wheat evolution.	Water	153-158	PIP3	Triticum aestivum	67-75
24417139-6	2013	CONCLUSION: Yield and content of carbohydrate from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba by water extraction-ethanol precipitation are a little higher than that by water extraction-acetone precipitation, but monosaccharide compositions are almost the same.	Water	113-118	afamin	Homo sapiens	105-109
23713706-2	2013	On a diamond electrode decorated with copper nanoparticles, CO2 reduction starts from -0.1 V versus a normal hydrogen electrode (NHE) when a mixture of water and ionic liquid ([H2O] = 10 muM) is used.	Water	152-157	solute carrier family 9 member C1	Homo sapiens	129-132
23713706-2	2013	On a diamond electrode decorated with copper nanoparticles, CO2 reduction starts from -0.1 V versus a normal hydrogen electrode (NHE) when a mixture of water and ionic liquid ([H2O] = 10 muM) is used.	Water	177-180	solute carrier family 9 member C1	Homo sapiens	129-132
23692429-4	2013	O2 reduction at FTO occurs at -0.33 V vs NHE, allowing for in situ detection of oxygen as it is formed by water oxidation on the surface.	Water	106-111	solute carrier family 9 member C1	Homo sapiens	41-44
23692429-5	2013	Controlled-potential electrolysis at 1.61 V vs NHE at pH 7.2 resulted in sustained water oxidation catalysis at a current density of 0.16 mA/cm(2) with 29,000 turnovers per site over an electrolysis period of 2 h. The turnover frequency for oxygen production per Co site was 4 s(-1) at an overpotential of 800 mV at pH 7.2.	Water	83-88	solute carrier family 9 member C1	Homo sapiens	47-50
23535949-0	2013	Catalytic isomerization of allylic alcohols in water by [RuClCp(PTA)2], [RuClCp(HPTA)2]Cl2 2H2O, [RuCp(DMSO-kappaS)(PTA)2]Cl, [RuCp(DMSO-kappaS)(PTA)2](OSO2CF3) and [RuCp(DMSO-kappaS)(HPTA)2]Cl3 2H2O.	Water	47-52	hepatocyte growth factor	Homo sapiens	80-84
23535949-0	2013	Catalytic isomerization of allylic alcohols in water by [RuClCp(PTA)2], [RuClCp(HPTA)2]Cl2 2H2O, [RuCp(DMSO-kappaS)(PTA)2]Cl, [RuCp(DMSO-kappaS)(PTA)2](OSO2CF3) and [RuCp(DMSO-kappaS)(HPTA)2]Cl3 2H2O.	Water	47-52	hepatocyte growth factor	Homo sapiens	184-188
23177919-0	2013	Silicic acid in drinking water prevents age-related alterations in the endothelium-dependent vascular relaxation modulating eNOS and AQP1 expression in experimental mice: an immunohistochemical study.	Water	25-30	aquaporin 1	Mus musculus	133-137
23856264-4	2013	Demonstration that the CaSR is expressed in the kidney as well as the parathyroid glands combined with more complete characterizations of FHH and ADH established that the effects of elevated Ca(2+) on the kidney (wasting of Na(+), K(+), Cl(-), Ca(2+), Mg(2+) and H2O) are attributable to activation of the CaSR.	Water	263-266	calcium-sensing receptor	Mus musculus	23-27
23322705-8	2013	Additionally, these data implicate the water-soluble inositol polyphosphates as mediators of the Cx43-dependent amplification of the osteoblast response to FGF2, and suggest that these low molecular weight second messengers may be biologically relevant mediators of osteoblast function that are communicated by Cx43-gap junctions.	Water	39-44	gap junction protein alpha 1	Homo sapiens	311-315
23848685-9	2013	Diffusivity of water in both SAP-1 and SAP-2 are found to be lower in comparison to the bulk, and within the two samples of saponite clay diffusivity in SAP-1 is found to be lower compared to SAP-2; this has been explained on the basis of the charge on the tetrahedral layers and the charge balancing cations in the interlayer spacing.	Water	15-20	leucine rich repeat and coiled-coil centrosomal protein 1	Homo sapiens	39-44
23702803-3	2013	The results showed that the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and the ability to inhibit hydroxy radical and glutathione (GSH) content were significantly (p &lt; 0.05 or p &lt; 0.01) decreased in the 300, 600 and 900 mg/kg groups in comparison with those of the control group.	Water	149-164	catalase-3	Glycine max	70-78
23702803-3	2013	The results showed that the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and the ability to inhibit hydroxy radical and glutathione (GSH) content were significantly (p &lt; 0.05 or p &lt; 0.01) decreased in the 300, 600 and 900 mg/kg groups in comparison with those of the control group.	Water	149-164	catalase-3	Glycine max	80-83
23586781-8	2013	Crystal structures of our NHA analogues bound to nNOS have been determined, revealing the presence of an active site water molecule only in the presence of singly methylated analogues.	Water	117-122	nitric oxide synthase 1	Homo sapiens	49-53
23796545-9	2013	Compared to conventional myelin water imaging, this new method of direct visualization of short relaxation time component (ViSTa) provides high quality images.	Water	32-37	V-set immunoregulatory receptor	Homo sapiens	123-128
24312215-2	2013	AQP0 plays an important role not only in the regulation of water content but also in cell-to-cell adhesion of the lens fiber cells.	Water	59-64	major intrinsic protein of lens fiber	Bos taurus	0-4
24121499-2	2013	We present evidence that either apoC-I or apoC-III, when bound to triglyceride-rich lipoproteins, prevent binding of LPL to the lipid/water interface.	Water	134-139	apolipoprotein C1	Homo sapiens	32-38
24121499-8	2013	In the presence of the LPL activator protein apoC-II, more of apoC-I or apoC-III was needed for displacement of LPL from the lipid/water interface.	Water	131-136	apolipoprotein C2	Homo sapiens	45-52
24121499-8	2013	In the presence of the LPL activator protein apoC-II, more of apoC-I or apoC-III was needed for displacement of LPL from the lipid/water interface.	Water	131-136	apolipoprotein C1	Homo sapiens	45-51
24150760-0	2013	ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity.	Water	90-93	aryl hydrocarbon receptor	Homo sapiens	33-58
23829545-7	2013	DISCUSSION: Diluted hydrofluoric acid is present in aqueous solution of SnF2 and TiF4 (which are known to inhibit dental erosion): SnF2 + 3H2O = Sn(OH)2 + 2HF + H2O and TiF4 + 5H2O = Ti(OH)4 + 4HF + H2O.	Water	161-164	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	72-76
23829545-7	2013	DISCUSSION: Diluted hydrofluoric acid is present in aqueous solution of SnF2 and TiF4 (which are known to inhibit dental erosion): SnF2 + 3H2O = Sn(OH)2 + 2HF + H2O and TiF4 + 5H2O = Ti(OH)4 + 4HF + H2O.	Water	161-164	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	131-135
23703259-1	2013	A direct chiral LC-UV method was optimized for the determination of salbutamol (SAL) beta2 -agonist in environmental water.	Water	117-122	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	85-90
23924052-9	2013	In addition, aquaporin 4 immunoreactivity increased early post-SCI, implicating this water channel in the development of edema after SCI.	Water	85-90	aquaporin-4	Oryctolagus cuniculus	13-24
24125784-5	2013	Stimulation of 5-HT1A receptors with 8-OH-DPAT (at 0.0, 2.0, 4.0, and 8.0 mug/0.5 mul/side) caused a dose-dependent decrease in food and water intake, and reduced rearing behavior but not ambulation.	Water	137-142	5-hydroxytryptamine receptor 1A	Rattus norvegicus	15-21
23572589-6	2013	Locally, differential incorporation of sulfur compounds into pyrite leads to preservation of S MIF, which is predicted to be most highly variable in nonmarine and shallow-water settings.	Water	171-176	macrophage migration inhibitory factor	Homo sapiens	95-98
23996000-4	2013	For elucidation of the structural bases for the mechanism of the proton collection and timely closure of the water channel, conformational dynamics after photolysis of CO (an O2 analog)-bound CcO was examined using a newly developed time-resolved infrared system feasible for accurate detection of a single C=O stretch band of alpha-helices of CcO in H2O medium.	Water	109-114	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	192-195
23996000-4	2013	For elucidation of the structural bases for the mechanism of the proton collection and timely closure of the water channel, conformational dynamics after photolysis of CO (an O2 analog)-bound CcO was examined using a newly developed time-resolved infrared system feasible for accurate detection of a single C=O stretch band of alpha-helices of CcO in H2O medium.	Water	351-354	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	192-195
24137132-11	2013	Taken together, these data confirm that mechanosensitive Cx30 hemichannels mediate tubular ATP release and purinergic calcium signaling in the CD which mechanism plays an important role in the regulation of CD salt and water reabsorption.	Water	219-224	gap junction protein, beta 6	Mus musculus	57-61
24088384-1	2013	BACKGROUND: The human mineralocorticoid receptor (MR) is one of the main components of the renin-angiotensin-aldosterone system (RAAS), the system that regulates the body exchange of water and sodium.	Water	183-188	nuclear receptor subfamily 3 group C member 2	Homo sapiens	22-48
24088384-1	2013	BACKGROUND: The human mineralocorticoid receptor (MR) is one of the main components of the renin-angiotensin-aldosterone system (RAAS), the system that regulates the body exchange of water and sodium.	Water	183-188	nuclear receptor subfamily 3 group C member 2	Homo sapiens	50-52
23926134-1	2013	Neuropeptide W (NPW), an endogenous ligand for G protein-coupled receptors NPBWR1 (GPR7) and NPBWR2 (GPR8), has been detected in neurons in limbic and reticular activating system areas known to be important in arousal, as well as hypothalamic nuclei known to be important in food and water intake and the neuroendocrine response to stress.	Water	284-289	neuropeptide W	Rattus norvegicus	0-14
23677388-3	2013	AQP3 and AQP10 are aqua-glyceroporins, known to transport glycerol as well as water.	Water	78-83	aquaporin 10	Homo sapiens	9-14
24494495-4	2013	Moreover, CO2 adsorption on the TEPA-Mg/DOBDC adsorbent was promoted by water vapor, and the adsorption capacity was enhanced to 8.31 mmol CO2/g absorbent.	Water	72-77	mucin 7, secreted	Homo sapiens	40-45
23810860-9	2013	Four principal components (PCs) were extracted from PCA, which explain 80.86% of the total parameters in water chemistry: PC1, the seawater intrusion and As contamination; PC2, the water-rock interaction, surface water recharge and acidic precipitation; PC3, heavy metal pollution from industry; and PC4, agricultural pollution and sewage intrusion.	Water	105-110	proprotein convertase subtilisin/kexin type 4	Homo sapiens	300-303
24038824-1	2013	Highly decorated: Tumor-associated MUC1 glycopeptide and tetanus toxoid T-cell epitope P2 can be attached to water-soluble poly(N-(2-hydroxypropyl)methacrylamide) carriers by orthogonal ligation techniques.	Water	109-114	mucin 1, cell surface associated	Homo sapiens	35-39
24028552-5	2013	The chloride"s overall affinity to the duplex is substantial in 25% water v/v in acetonitrile (log beta2 = 12.6), and it remains strong (log beta2 = 13.0) as the water content is increased to 50%.	Water	68-73	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	99-104
24028552-5	2013	The chloride"s overall affinity to the duplex is substantial in 25% water v/v in acetonitrile (log beta2 = 12.6), and it remains strong (log beta2 = 13.0) as the water content is increased to 50%.	Water	68-73	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	141-146
24028552-5	2013	The chloride"s overall affinity to the duplex is substantial in 25% water v/v in acetonitrile (log beta2 = 12.6), and it remains strong (log beta2 = 13.0) as the water content is increased to 50%.	Water	162-167	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	141-146
23701967-1	2013	Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols through the addition of a water molecule.	Water	115-120	epoxide hydrolase 2	Homo sapiens	10-35
23701967-1	2013	Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols through the addition of a water molecule.	Water	115-120	epoxide hydrolase 2	Homo sapiens	37-40
23860663-7	2013	In this report we successfully demonstrate that this unique proton-coupled low-energy pathway actually takes place with the use of a mild oxidant such as the photogenerated [Ru(bpy)3](3+) (1.26 V vs. NHE) to drive water oxidation.	Water	214-219	solute carrier family 9 member C1	Homo sapiens	200-203
27759379-6	2016	Notable is the direct modeling of steric repulsion between the water Drude oscillators and Mg2+ to treat the Pauli exclusion effects associated with overlap of the electron clouds of water molecules in the first hydration shell around Mg2+.	Water	183-188	mucin 7, secreted	Homo sapiens	235-238
27791208-3	2016	Moreover, their excellent bifunctional catalytic performance was also explored in the overall water splitting test (eta = 760 mV for 10 mA cm-2).	Water	94-99	endothelin receptor type A	Homo sapiens	116-119
27775322-2	2016	In ozonation experiments we simultaneously determined kinetics and dose-dependent inactivation of Escherichia coli and its plasmid-encoded sulfonamide resistance gene sul1 in different water matrixes.	Water	185-190	dihydropteroate synthase	Escherichia coli	167-171
27331928-0	2016	Contrast-Enhanced Dixon Fat-Water Separation Imaging of the Spine: Added Value of Fat, In-Phase and Opposed-Phase Imaging in Marrow Lesion Detection.	Water	28-33	FAT atypical cadherin 1	Homo sapiens	24-27
27331928-1	2016	OBJECTIVE: Beyond fat suppression (FS), the efficacy of (fat-water separation or Dixon [FWD]) Dixon imaging in gadolinium-enhanced spine imaging has yet to be validated.	Water	61-66	FAT atypical cadherin 1	Homo sapiens	57-60
27404940-5	2016	Further, Dyt1 KI mice demonstrated elevated free-water (FW) in the striatum and cerebellum compared to WT mice, and increased FW was correlated with impairments in functional connectivity across basal ganglia, cerebellum, and sensorimotor cortex.	Water	49-54	torsin family 1, member A (torsin A)	Mus musculus	9-13
23831521-7	2013	In addition, AD mice treated with NEP showed improved behavioral performance on the water maze test.	Water	84-89	membrane metallo endopeptidase	Mus musculus	34-37
23692366-11	2013	Together, our results suggest that beta-CD might represent an important tool for improvement of analgesic and anti-inflammatory profiles of (-)-linalool and other water-insoluble compounds, such as lipophilic monoterpenes or essential oils.	Water	163-168	beta-carotene oxygenase 1	Mus musculus	35-42
27818670-5	2016	Indeed, overexpression of HvPIP2;5 caused higher retention of chlorophylls and water under salt and osmotic stresses than did control.	Water	79-84	PIP2;5	Hordeum vulgare	26-34
27717159-3	2016	The delta-value for aqueous GVL solvent increased from 23.1 MPa1/2 for pure GVL to 45.6 MPa1/2 for pure water.	Water	104-109	guanylate binding protein 4	Homo sapiens	88-94
23991073-2	2013	SP-B promotes spreading and adsorption of surfactant at the alveolar air-water interface and may facilitate connections between the surface layer and underlying lamellar reservoirs of surfactant material.	Water	73-78	surfactant protein B	Homo sapiens	0-4
23910967-6	2013	Specific retention of MC-LR on the mIS was demonstrated with extraction recovery above 70% in pure water.	Water	99-104	anti-Mullerian hormone	Mus musculus	35-38
27734966-6	2016	This high-resolution structure allows the accurate mapping of the interaction including water-mediated hydrogen bonds and provides, for the first time, a coherent explanation of PD-1 antagonism by pembrolizumab.	Water	88-93	programmed cell death 1	Homo sapiens	178-182
23806103-6	2013	Current densities of 10.5 and 8.70 mA/cm(2), respectively, were reached at +1.8 V vs NHE with H2O oxidation onsets at +1.3 and +1.4 V, respectively.	Water	94-97	solute carrier family 9 member C1	Homo sapiens	85-88
23806103-11	2013	Films containing Co(II) reached current densities of 6.0 mA/cm(2) at +1.8 V vs NHE in H2O.	Water	86-89	solute carrier family 9 member C1	Homo sapiens	79-82
23611340-6	2013	His18 residue of hIAPP binds heme under physiological conditions and results in an axial high-spin active site with a trans-axial water derived ligand.	Water	130-135	islet amyloid polypeptide	Homo sapiens	17-22
27699080-6	2016	An intravenous injection of AVP into the tail induced decreases in the drinking frequency and water intake in the mice, and these decreases were associated with increases in brain formaldehyde levels.	Water	94-99	arginine vasopressin	Mus musculus	28-31
23737726-6	2013	By imaging under water, the capillary force is eliminated on ODT SAMs, which leads to a lower lateral force.	Water	17-22	methionine adenosyltransferase 1A	Homo sapiens	65-69
23737726-7	2013	However, the lateral force image was reversed on MHA SAMs, which suggested that hydrophobic forces dominated in water.	Water	112-117	methionine adenosyltransferase 1A	Homo sapiens	53-57
27699080-9	2016	These data suggest that the interaction between formaldehyde and AVP affects the water intake behaviors of mice.	Water	81-86	arginine vasopressin	Mus musculus	65-68
23643891-3	2013	The main findings are the existence of a contiguous water channel across the bilayer in the presence of TAT peptide.	Water	52-57	tyrosine aminotransferase	Homo sapiens	104-107
27460145-3	2016	We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates alpha3, alpha4, alpha5, alpha6, alpha7, beta2, and beta4 nAChR subunits from human and rat cortical extracts, and rat midbrain and olfactory bulb extracts, suggesting that Lynx1 forms complexes with multiple nAChR subtypes in the human and rodent brain.	Water	53-58	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	118-148
23425894-0	2013	Health implications of PAH release from coated cast iron drinking water distribution systems in The Netherlands.	Water	66-71	phenylalanine hydroxylase	Homo sapiens	23-26
27460145-3	2016	We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates alpha3, alpha4, alpha5, alpha6, alpha7, beta2, and beta4 nAChR subunits from human and rat cortical extracts, and rat midbrain and olfactory bulb extracts, suggesting that Lynx1 forms complexes with multiple nAChR subtypes in the human and rodent brain.	Water	53-58	Ly6/neurotoxin 1	Rattus norvegicus	94-99
27656877-13	2016	There are significant changes of SP-A and SP-C levels in diseases affecting brain water circulation and elevation of intracranial pressure.	Water	82-87	surfactant protein A1	Homo sapiens	33-37
24159882-2	2013	The DSC results showed that four interlayer water molecules were lost when they were heated at 300 degrees C. As the temperature increased to 724 degrees C, Si-O-H bonds were cleaved and dehydroxylation occurred.	Water	44-49	desmocollin 3	Homo sapiens	4-7
23567951-0	2013	Bivalent angiotensin II suppresses oxidative stress-induced hyper-responsiveness of angiotensin II receptor type I. Angiotensin II receptor type I (AT1R) is a G-protein coupled receptor involved in regulation of body water-electrolyte balance and blood pressure.	Water	217-222	angiotensin II receptor type 1	Homo sapiens	148-152
27530898-2	2016	When SC1, SC2, and SC3 were suspended in water, the entrapped [Ru(bipy)3 ]2+ dye was free to diffuse from the inner pores to the solution.	Water	41-46	transcription factor 19	Homo sapiens	5-8
23619363-5	2013	Moreover, the renal responses to high serum Ang II observed in wild-type mice, including intrarenal Ang II accumulation, sodium and water retention, and activation of ion transporters in the loop of Henle (NKCC2) and distal nephron (NCC, ENaC, and pendrin) as well as the transporter activating kinases SPAK and OSR1, were effectively prevented in mice that lack kidney ACE.	Water	132-137	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	44-47
23732168-0	2013	Inhibition of water absorption and selective damage to human colonic mucosa are induced by subtilase cytotoxin produced by Escherichia coli O113:H21.	Water	14-19	proprotein convertase subtilisin/kexin type 5	Homo sapiens	91-100
23666033-2	2013	The addition of water caused the phen ligands to deviate slightly from the U2(mu2-F)2 plane, and red-shifts the U-F-terminal and U = O stretching vibrations.	Water	16-21	adaptor related protein complex 1 subunit mu 2	Homo sapiens	78-81
27450300-4	2016	The pyridine containing water soluble complexes (CuL(1) and CuL(3)) are much more cytotoxic than the corresponding pyrrole counterparts (CuL(2) and CuL(4)).	Water	24-29	cullin 1	Homo sapiens	49-55
23754513-7	2013	In the EG + 50 % ONB and EG + 100 % ONB groups, ONB water significantly decreased renal CaOx deposits, urinary NAG excretion, and renal monocyte chemoattractant protein-1, osteopontin, and hyaluronic acid expression and increased renal superoxide dismutase-1 expression compared with the EG group.	Water	52-57	O-GlcNAcase	Rattus norvegicus	111-114
23754513-7	2013	In the EG + 50 % ONB and EG + 100 % ONB groups, ONB water significantly decreased renal CaOx deposits, urinary NAG excretion, and renal monocyte chemoattractant protein-1, osteopontin, and hyaluronic acid expression and increased renal superoxide dismutase-1 expression compared with the EG group.	Water	52-57	secreted phosphoprotein 1	Rattus norvegicus	172-183
27450300-4	2016	The pyridine containing water soluble complexes (CuL(1) and CuL(3)) are much more cytotoxic than the corresponding pyrrole counterparts (CuL(2) and CuL(4)).	Water	24-29	cullin 3	Homo sapiens	60-66
27354732-3	2016	It is hoped that nature can inspire the creation of materials to aid in the supply and management of water, from water collection and purification to water source clean-up and rehabilitation from oil contamination.	Water	101-106	activation induced cytidine deaminase	Homo sapiens	65-68
24967239-3	2013	After ingestion of a salty meal, GN and UGN are secreted into the intestinal lumen, where they inhibit sodium absorption and induce anion and water secretion.	Water	142-147	guanylate cyclase activator 2b (retina)	Mus musculus	40-43
27354732-3	2016	It is hoped that nature can inspire the creation of materials to aid in the supply and management of water, from water collection and purification to water source clean-up and rehabilitation from oil contamination.	Water	113-118	activation induced cytidine deaminase	Homo sapiens	65-68
27354732-3	2016	It is hoped that nature can inspire the creation of materials to aid in the supply and management of water, from water collection and purification to water source clean-up and rehabilitation from oil contamination.	Water	113-118	activation induced cytidine deaminase	Homo sapiens	65-68
23530595-6	2013	However, when the films are exposed to water, which "switches off" the noncovalent CNC interactions, a significant mechanical contrast is observed between the same films.	Water	39-44	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	83-86
27380126-8	2016	Our results indicate that Ag-NPs entering soils through the wastewater-sludge-soil pathway pose low risk to plants due to their conversion to Ag2S in the wastewater treatment process, although bioavailability may increase in saline soils or when irrigated with high-Cl water.	Water	65-70	angiotensin II receptor type 1	Homo sapiens	142-146
23415322-5	2013	Moreover, the ectopic expression of the AtRZF1 gene was very significantly influential in drought sensitive parameters including proline content, water loss, membrane ion leakage and the expression of dehydration stress-related genes.	Water	146-151	RING/U-box superfamily protein	Arabidopsis thaliana	40-46
27252474-5	2016	Water intake by Nax/TRPV4-double KO mice was similar to that by the respective single KO mice.	Water	0-5	sodium channel, voltage-gated, type VII, alpha	Mus musculus	16-19
27252474-9	2016	These results suggest that the Na(+) signal generated in Nax-positive glial cells leads to the activation of TRPV4-positive neurons in sCVOs to stimulate water intake by using EETs as gliotransmitters.	Water	154-159	sodium channel, voltage-gated, type VII, alpha	Mus musculus	57-60
23395731-0	2013	Disruption of dystroglycan-laminin interactions modulates water uptake by astrocytes.	Water	58-63	dystroglycan 1	Homo sapiens	14-26
23395731-4	2013	Since loss of the astrocyte adhesion receptor dystroglycan has been associated with disrupted polarization of ion and water channels, we hypothesized that adhesion of astrocytes to the ECM contributes to regulation of water uptake, and that disruption of matrix adhesion impairs the ability of astrocytes to direct water transport.	Water	118-123	dystroglycan 1	Homo sapiens	46-58
27176940-8	2016	As effect-based sediment-water distribution ratios demonstrated, most of the bioactivity in the AhR-CAFLUX was attributable to hydrophobic chemicals while more hydrophilic chemicals activated AREc32, even though bioanalytical equivalents in the aqueous phase remained negligible.	Water	25-30	aryl hydrocarbon receptor	Homo sapiens	96-99
23395731-4	2013	Since loss of the astrocyte adhesion receptor dystroglycan has been associated with disrupted polarization of ion and water channels, we hypothesized that adhesion of astrocytes to the ECM contributes to regulation of water uptake, and that disruption of matrix adhesion impairs the ability of astrocytes to direct water transport.	Water	218-223	dystroglycan 1	Homo sapiens	46-58
23395731-7	2013	Moreover, inhibiting proteolytic cleavage of dystroglycan that occurs in OGD abrogated the effect of OGD, but not direct blockade of alpha-dystroglycan, indicating that interfering with dystroglycan-matrix binding itself affects water uptake.	Water	229-234	dystroglycan 1	Homo sapiens	45-57
23395731-9	2013	These studies demonstrate for the first time that water uptake in astrocytes is regulated by dystroglycan-dependent signaling associated with matrix adhesion.	Water	50-55	dystroglycan 1	Homo sapiens	93-105
23556701-2	2013	Interfacial water/substrate pseudoepitaxy turns out to be a critical parameter since ice is only formed when the lattice mismatch is small, an observation based on the absence of ice on (111) surfaces of isostructural CaF2.	Water	12-17	CCR4-NOT transcription complex subunit 8	Homo sapiens	218-222
25994218-9	2016	CONCLUSIONS: Dominant gain-of-function GUCY2C mutations lead to elevated intracellular cyclic guanosine monophosphate levels and could explain the chronic diarrhoea as a result of decreased intestinal sodium and water absorption and increased chloride secretion.	Water	212-217	guanylate cyclase 2C	Homo sapiens	39-45
23556707-0	2013	Lattice Boltzmann implementation of the three-dimensional Ben-Naim potential for water-like fluids.	Water	81-86	GTF2I repeat domain containing 1	Homo sapiens	58-61
23556707-2	2013	Ben-Naim, Molecular Theory of Water and Aqueous Solutions: Part I: Understanding Water (World Scientific Publishing Company, 2010); "Statistical mechanics of "waterlike" particles in two dimensions.	Water	30-35	GTF2I repeat domain containing 1	Homo sapiens	0-3
23556707-2	2013	Ben-Naim, Molecular Theory of Water and Aqueous Solutions: Part I: Understanding Water (World Scientific Publishing Company, 2010); "Statistical mechanics of "waterlike" particles in two dimensions.	Water	81-86	GTF2I repeat domain containing 1	Homo sapiens	0-3
23428156-5	2013	We show that weak wave turbulence is the dominant mechanism in the behavior of the system, as evident from wave height frequency spectra that closely follow the Rayleigh-Jeans spectral response eta   omega(-17/12) as a consequence of a period-halving, weakly turbulent cascade that appears within a 1 mm water drop whether driven by thickness-mode or surface acoustic Rayleigh wave excitation.	Water	304-309	endothelin receptor type A	Homo sapiens	194-197
28530326-0	2016	[SERUM THYROGLOBULIN LEVELS AND ESTIMATED IODINE INTAKE IN ADULTS EXPOSED TO IODINE-DILUTED DESALINATED DRINKING WATER].	Water	113-118	thyroglobulin	Homo sapiens	7-20
29498811-1	2016	The estates team at St George"s Hospital in south London say the deployment of a web-based software system which verifies that "responsible" staff across the site have regularly flushed low-use water outlets to maintain flow, and thus prevent potentially dangerous waterborne bacteria building up in pipework, has "very substantially" increased compliance with approved flushing practice--as set out in the HSE"s L8 Approved Code of Practice on controlling Legionella bacteria in water systems, and the new HTM 04-01, Safe Water in Healthcare Premises.	Water	194-199	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	407-410
29498811-1	2016	The estates team at St George"s Hospital in south London say the deployment of a web-based software system which verifies that "responsible" staff across the site have regularly flushed low-use water outlets to maintain flow, and thus prevent potentially dangerous waterborne bacteria building up in pipework, has "very substantially" increased compliance with approved flushing practice--as set out in the HSE"s L8 Approved Code of Practice on controlling Legionella bacteria in water systems, and the new HTM 04-01, Safe Water in Healthcare Premises.	Water	523-528	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	407-410
27600972-2	2016	The objective of the present study was to examine the ability of water soluble extracts (WSE) obtained from traditional Greek yoghurt made from bovine or ovine milk to modulate the expression of u-PA, u-PAR, PAI-1 and PAI-2 in ovine monocytes and neutrophils.	Water	65-70	serpin family E member 1	Bos taurus	208-213
23667716-4	2013	The crystal structure of the small molecule-gp120 complex reveals the displacement of crystallographic water and the formation of a hydrogen bond with a backbone carbonyl of the bridging sheet.	Water	103-108	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	44-49
23270855-2	2013	Therefore, in the present study we investigated the effects of the activation of mu-ORs in the CeA on 0.3 M NaCl and water intake in rats.	Water	117-122	carcinoembryonic antigen gene family 4	Rattus norvegicus	95-98
28461893-4	2016	Presented in this article, along with only the second neutron structure of a clinical drug-bound hCA, is an in-depth structural comparison and analyses of differences in hydrogen-bonding network, water-molecule orientation and solvent displacement that take place upon the binding of AZM and MZM in the active site of hCA II.	Water	196-201	HCA1	Homo sapiens	97-100
23270855-7	2013	injected subcutaneously, bilateral injections of DAMGO 2 nmol into the CeA increased 0.3 M NaCl intake and water intake and the blockade of mu-ORs with CTAP 1 nmol injected into the CeA reduced the increase in 0.3 M NaCl intake and water intake induced by DAMGO 2 nmol into the same site.	Water	107-112	carcinoembryonic antigen gene family 4	Rattus norvegicus	71-74
27295580-1	2016	Herein, we report the fabrication of visible-light-active NaNbO3 /Ag2 S staggered-gap core-shell semiconductor heterostructures with excellent photoelectrochemical activity toward water splitting, and the degradation of a model pollutant (methylene blue) was also monitored.	Water	180-185	angiotensin II receptor type 1	Homo sapiens	66-71
23327241-6	2013	Finally, greater exposure to fluoridated water significantly reduced the association between children"s SSB consumption and dental caries.	Water	41-46	small RNA binding exonuclease protection factor La	Homo sapiens	104-107
23327241-8	2013	However, increased exposure to fluoridated public water helped ameliorate the association between SSB consumption and dental decay.	Water	50-55	small RNA binding exonuclease protection factor La	Homo sapiens	98-101
27347685-1	2016	Parallel aligned mesopore arrays in pyramidal-shaped GaN are fabricated by using an electrochemical anodic etching technique, followed by inductively coupled plasma etching assisted by SiO2 nanosphere lithography, and used as a promising photoelectrode for solar water oxidation.	Water	263-268	gigaxonin	Homo sapiens	53-56
23324261-0	2013	One-pot synthesis of water-dispersible Ag2S quantum dots with bright fluorescent emission in the second near-infrared window.	Water	21-26	angiotensin II receptor type 1	Homo sapiens	39-43
27314147-5	2016	We find that the freezing temperature of water decreases with increasing surface hydrophobicity only when the sample volume is small (~10 muL).	Water	41-46	tripartite motif containing 37	Homo sapiens	138-141
27314147-6	2016	For a larger volume of water (~300 muL), the freezing temperature is independent of surface energy.	Water	23-28	tripartite motif containing 37	Homo sapiens	35-38
23298255-6	2013	A water molecule trapped inside the PTP-binding loop makes close contacts both with main chain and with side chain atoms.	Water	2-7	protein tyrosine phosphatase receptor type U	Homo sapiens	36-39
27383386-7	2016	Overexpression of MnSOD also increased the expression of aquaporin-1 (AQP1), a water and oxygen channel.	Water	79-84	aquaporin 1	Mus musculus	57-68
23442910-1	2013	The hydrophobic surfactant proteins, SP-B and SP-C, greatly accelerate the adsorption of the surfactant lipids to an air/water interface.	Water	121-126	surfactant protein B	Homo sapiens	37-41
27383386-7	2016	Overexpression of MnSOD also increased the expression of aquaporin-1 (AQP1), a water and oxygen channel.	Water	79-84	aquaporin 1	Mus musculus	70-74
27283444-1	2016	This report presents a systematic investigation of the interactions of water molecule(s) with a series of amino acid cations (Gly(+), Ala(+), Val(+), and Leu(+)), halogen anions (Cl(-), Br(-), BF4 (-), and PF6 (-)), and clusters (GlyCl) n (n = 1-5).	Water	71-76	sperm associated antigen 17	Homo sapiens	206-209
22057895-2	2013	In adult mouse brain, inwardly rectifying K+ (Kir4.1) and aquaporin-4 (AQP4) channels localize to astroglial endfeets in contact with brain microvessels and glutamate synapses, optimizing clearance of extracellular K(+) and water from the synaptic layers.	Water	224-229	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	46-52
22057895-9	2013	The time course and expression pattern suggests that Kir4.1 and AQP4 channels may play an important role in brain K(+) and water homeostasis in early postnatal weeks after birth and during aging.	Water	123-128	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	53-59
27350190-0	2016	Water Deprivation Increases (Pro)renin Receptor Levels in the Kidney and Decreases Plasma Concentrations of Soluble (Pro)renin Receptor.	Water	0-5	renin	Rattus norvegicus	33-38
23160514-6	2013	EP3 and microsomal PG synthase type 1 play a role in decreasing collecting duct water permeability and increasing water excretion, whereas EP2 and EP4 can bypass vasopressin signaling and increase water reabsorption through two different intracellular signaling pathways.	Water	80-85	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	0-3
23160514-6	2013	EP3 and microsomal PG synthase type 1 play a role in decreasing collecting duct water permeability and increasing water excretion, whereas EP2 and EP4 can bypass vasopressin signaling and increase water reabsorption through two different intracellular signaling pathways.	Water	114-119	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	0-3
23922885-8	2013	RESULTS: Hepatic glucokinase activity was signficantly suppressed after 2 hours in animals given an oral BPA bolus compared to those who received only water (p = 0.002-0.029 at glucose 5-20 mmol/l; overall treatment effect p&lt;0.001).	Water	151-156	glucokinase	Mus musculus	17-28
23739035-1	2013	We investigate the energetic stability and dissociation dynamics of water adsorption at the LaAlO3 surface of the n-type LaAlO3/SrTiO3 (LAO/STO) interface and its effect on the electronic properties of the interface by carrying out first-principles electronic structure calculations.	Water	68-73	interleukin 4 induced 1	Homo sapiens	136-143
23739035-3	2013	Water molecule dissociation induces an up-shift of the valence band maximum (VBM) of the LAO surface, reducing the gap between the VBM of the LAO surface and the conduction band minimum of the STO.	Water	0-5	interleukin 4 induced 1	Homo sapiens	89-92
27350190-0	2016	Water Deprivation Increases (Pro)renin Receptor Levels in the Kidney and Decreases Plasma Concentrations of Soluble (Pro)renin Receptor.	Water	0-5	renin	Rattus norvegicus	121-126
23739035-3	2013	Water molecule dissociation induces an up-shift of the valence band maximum (VBM) of the LAO surface, reducing the gap between the VBM of the LAO surface and the conduction band minimum of the STO.	Water	0-5	interleukin 4 induced 1	Homo sapiens	142-145
23739035-3	2013	Water molecule dissociation induces an up-shift of the valence band maximum (VBM) of the LAO surface, reducing the gap between the VBM of the LAO surface and the conduction band minimum of the STO.	Water	0-5	nuclear receptor binding SET domain protein 1	Homo sapiens	193-196
27350190-1	2016	Water deprivation activates the renin-angiotensin system.	Water	0-5	renin	Rattus norvegicus	32-37
23739035-4	2013	For the LAO/STO interface with three LAO unit-cell layers, once the coverage of dissociated water molecules reaches 1/2 ML the gap is closed, the interface becomes metallic and the carrier density at the LAO/STO interface increases with increasing coverage of dissociated water molecules.	Water	92-97	interleukin 4 induced 1	Homo sapiens	8-11
23739035-4	2013	For the LAO/STO interface with three LAO unit-cell layers, once the coverage of dissociated water molecules reaches 1/2 ML the gap is closed, the interface becomes metallic and the carrier density at the LAO/STO interface increases with increasing coverage of dissociated water molecules.	Water	92-97	nuclear receptor binding SET domain protein 1	Homo sapiens	12-15
27347960-4	2016	Experiments were implemented and results showed that water flow rates within a wide range of tens to hundreds of muL/min could be detected.	Water	53-58	tripartite motif containing 37	Homo sapiens	113-116
23739035-4	2013	For the LAO/STO interface with three LAO unit-cell layers, once the coverage of dissociated water molecules reaches 1/2 ML the gap is closed, the interface becomes metallic and the carrier density at the LAO/STO interface increases with increasing coverage of dissociated water molecules.	Water	92-97	interleukin 4 induced 1	Homo sapiens	37-40
23739035-4	2013	For the LAO/STO interface with three LAO unit-cell layers, once the coverage of dissociated water molecules reaches 1/2 ML the gap is closed, the interface becomes metallic and the carrier density at the LAO/STO interface increases with increasing coverage of dissociated water molecules.	Water	92-97	interleukin 4 induced 1	Homo sapiens	8-15
23739035-4	2013	For the LAO/STO interface with three LAO unit-cell layers, once the coverage of dissociated water molecules reaches 1/2 ML the gap is closed, the interface becomes metallic and the carrier density at the LAO/STO interface increases with increasing coverage of dissociated water molecules.	Water	272-277	interleukin 4 induced 1	Homo sapiens	8-11
23739035-4	2013	For the LAO/STO interface with three LAO unit-cell layers, once the coverage of dissociated water molecules reaches 1/2 ML the gap is closed, the interface becomes metallic and the carrier density at the LAO/STO interface increases with increasing coverage of dissociated water molecules.	Water	272-277	nuclear receptor binding SET domain protein 1	Homo sapiens	12-15
23739035-4	2013	For the LAO/STO interface with three LAO unit-cell layers, once the coverage of dissociated water molecules reaches 1/2 ML the gap is closed, the interface becomes metallic and the carrier density at the LAO/STO interface increases with increasing coverage of dissociated water molecules.	Water	272-277	interleukin 4 induced 1	Homo sapiens	37-40
27252118-2	2016	In this work, a hybrid probe based on guanidinium-pendent oligofluorene (G-OF) and water-soluble conjugated polythiophene (PTP) has been developed for the turn on detection of CO2 with low background signal, taking advantage of the efficient fluorescence quenching of the tight aggregate of G-OF/PTP.	Water	83-88	protein tyrosine phosphatase receptor type U	Homo sapiens	123-126
23739035-4	2013	For the LAO/STO interface with three LAO unit-cell layers, once the coverage of dissociated water molecules reaches 1/2 ML the gap is closed, the interface becomes metallic and the carrier density at the LAO/STO interface increases with increasing coverage of dissociated water molecules.	Water	272-277	interleukin 4 induced 1	Homo sapiens	8-15
23739035-5	2013	Our findings suggest two ways to control the conductivity at the LAO/STO interface: (I) an insulator-metal transition by adsorbing an amount of water at the bare surface; (II) a carrier density change by the transition between the most stable and the metastable adsorption configurations for 1 ML coverage in an ambient atmosphere at room temperature.	Water	144-149	interleukin 4 induced 1	Homo sapiens	65-68
23739035-5	2013	Our findings suggest two ways to control the conductivity at the LAO/STO interface: (I) an insulator-metal transition by adsorbing an amount of water at the bare surface; (II) a carrier density change by the transition between the most stable and the metastable adsorption configurations for 1 ML coverage in an ambient atmosphere at room temperature.	Water	144-149	nuclear receptor binding SET domain protein 1	Homo sapiens	69-72
27252118-2	2016	In this work, a hybrid probe based on guanidinium-pendent oligofluorene (G-OF) and water-soluble conjugated polythiophene (PTP) has been developed for the turn on detection of CO2 with low background signal, taking advantage of the efficient fluorescence quenching of the tight aggregate of G-OF/PTP.	Water	83-88	protein tyrosine phosphatase receptor type U	Homo sapiens	291-299
23670531-0	2013	Changes in helical content or net charge of apolipoprotein C-I alter its affinity for lipid/water interfaces.	Water	92-97	apolipoprotein C1	Homo sapiens	44-62
27306053-4	2016	Acclimation to high-Cl(-) artificial water stimulated the mRNA expression of cgrp and the receptor (crlr1) when compared with low-Cl(-) CGRP knockdown induced upregulation of the Na(+)-Cl(-) co-transporter (ncc2b), while overexpression of CGRP resulted in the downregulation of ncc2b mRNA synthesis and a simultaneous decrease in Cl(-) uptake in embryos.	Water	37-42	solute carrier family 12 member 10, tandem duplicate 2	Danio rerio	207-212
23670531-2	2013	To probe the role of alpha-helical structure in protein-lipid interactions, we used oil-drop tensiometry to characterize the interfacial behavior of apolipoprotein C-I (apoC-I) variants at triolein/water (TO/W) and 1-palmitoyl-2-oleoylphosphatidylcholine/triolein/water (POPC/TO/W) interfaces.	Water	198-203	apolipoprotein C1	Homo sapiens	149-167
23670531-2	2013	To probe the role of alpha-helical structure in protein-lipid interactions, we used oil-drop tensiometry to characterize the interfacial behavior of apolipoprotein C-I (apoC-I) variants at triolein/water (TO/W) and 1-palmitoyl-2-oleoylphosphatidylcholine/triolein/water (POPC/TO/W) interfaces.	Water	198-203	apolipoprotein C1	Homo sapiens	169-175
23782508-6	2013	This updating seems to be mediated by the activation of angiotensin AT1 receptors in the dorsal hippocampus and local infusion of human angiotensin II (ANGII) was shown to mimic the water deprivation effects on memory reconsolidation.	Water	182-187	angiotensin II receptor type 1	Homo sapiens	68-71
27306053-4	2016	Acclimation to high-Cl(-) artificial water stimulated the mRNA expression of cgrp and the receptor (crlr1) when compared with low-Cl(-) CGRP knockdown induced upregulation of the Na(+)-Cl(-) co-transporter (ncc2b), while overexpression of CGRP resulted in the downregulation of ncc2b mRNA synthesis and a simultaneous decrease in Cl(-) uptake in embryos.	Water	37-42	solute carrier family 12 member 10, tandem duplicate 2	Danio rerio	278-283
23618281-1	2013	A water-soluble inclusion complex of hypericin (HY) with beta-cyclodextrin polymer (CDP) was achieved by supramolecular interactions between HY and CDP.	Water	2-7	cut like homeobox 1	Homo sapiens	57-88
27109612-4	2016	Instead, the phenotype was associated with impaired skin barrier function and a defective stratum corneum, with SerpinB2(-/-) mice showing increased transepidermal water loss, increased overt loss of stratum corneum in inflammatory lesions, and impaired stratum corneum thickening after phorbol ester treatment.	Water	164-169	serine (or cysteine) peptidase inhibitor, clade B, member 2	Mus musculus	112-120
27115555-3	2016	The high specificity of PFI-3 for family VIII was achieved through a novel bromodomain binding mode of a phenolic headgroup that led to the unusual displacement of water molecules that are generally retained by most other bromodomain inhibitors reported to date.	Water	164-169	cytochrome c oxidase subunit 8A	Homo sapiens	41-45
23918875-1	2013	PG102, a water-soluble extract from an edible fruit, Actinidia arguta, has previously been shown to control various factors involved in allergy pathogenesis.	Water	9-14	interphotoreceptor matrix proteoglycan 2	Mus musculus	0-5
27138325-3	2016	The water peak in the NMR spectrum was selectively saturated, and the STD amplitudes for TBP were observed in the presence of TiO2, demonstrating that the side chains of the N-terminal residues Arg1 and Lys2 exhibit the strongest saturation transfer effect from water molecules; i.e., the two N-terminal residues are in contact with the TiO2 surface.	Water	4-9	arginase 1	Homo sapiens	194-198
23587488-2	2013	As the main small integral membrane proteins that selectively conduct water molecules" transportation, aquaporin (AQP)-1 downregulation significantly related to lung edema and inflammation.	Water	70-75	aquaporin 1	Rattus norvegicus	114-120
27138325-3	2016	The water peak in the NMR spectrum was selectively saturated, and the STD amplitudes for TBP were observed in the presence of TiO2, demonstrating that the side chains of the N-terminal residues Arg1 and Lys2 exhibit the strongest saturation transfer effect from water molecules; i.e., the two N-terminal residues are in contact with the TiO2 surface.	Water	262-267	arginase 1	Homo sapiens	194-198
27145200-5	2016	These mechanisms are correlated with each sorbents" resistance to accelerated liquid H2O and TGA steam treatments (H2O stability) and to oxidative degradation (thermal stability).	Water	115-118	T-box transcription factor 1	Homo sapiens	93-96
23744886-1	2013	Aquaporin-1 (AQP1) facilitates the osmotic transport of water across the capillary endothelium, among other cell types, and thereby has a substantial role in ultrafiltration during peritoneal dialysis.	Water	56-61	aquaporin 1	Mus musculus	0-11
23744886-1	2013	Aquaporin-1 (AQP1) facilitates the osmotic transport of water across the capillary endothelium, among other cell types, and thereby has a substantial role in ultrafiltration during peritoneal dialysis.	Water	56-61	aquaporin 1	Mus musculus	13-17
23744886-2	2013	At present, pharmacologic agents that enhance AQP1-mediated water transport, which would be expected to increase the efficiency of peritoneal dialysis, are not available.	Water	60-65	aquaporin 1	Mus musculus	46-50
23744886-9	2013	In summary, AqF026 directly and specifically potentiates AQP1-mediated water transport, suggesting that it deserves additional investigation for applications such as peritoneal dialysis or clinical situations associated with defective water handling.	Water	71-76	aquaporin 1	Mus musculus	57-61
27090616-6	2016	Interestingly, these MOFs represent excellent fluorescent properties, which can be efficiently quenched by trace amounts of nitrofurazone (NZF) and nitrofurantoin (NFT) antibiotics as well as 2,4,6-trinitrophenol (TNP) and 4-nitrophenol (4-NP) organic explosives in water solution.	Water	266-271	PHD finger protein 20	Homo sapiens	139-142
23322705-8	2013	Additionally, these data implicate the water-soluble inositol polyphosphates as mediators of the Cx43-dependent amplification of the osteoblast response to FGF2, and suggest that these low molecular weight second messengers may be biologically relevant mediators of osteoblast function that are communicated by Cx43-gap junctions.	Water	39-44	gap junction protein alpha 1	Homo sapiens	97-101
26951941-4	2016	We showed that the inhibitory effect of E2 on ANGII-induced water and sodium intake requires the ERK1/2 and JNK signaling pathways.	Water	60-65	mitogen activated protein kinase 3	Rattus norvegicus	97-103
24010292-0	2013	[Analysis on chemical components from water extract of paeoniae radix alba by high performance liquid chromatography-electrospray ionization-quadrupole-time of flight-mass spectrometry].	Water	38-43	afamin	Homo sapiens	70-74
24010292-1	2013	This experiment was performed to establish a qualitative analysis on chemical composition in water extract of Paeoniae Radix Alba by HPLC-ESI-Q-TOF-MS.	Water	93-98	afamin	Homo sapiens	125-129
24010292-3	2013	The results showed that eleven compounds from water extract of Paeoniae Radix Alba had been identified by analyzing positive and negative ion mass data including element composition and by comparing with data from literatures.	Water	46-51	afamin	Homo sapiens	78-82
24010292-4	2013	Since efficient separation of HPLC and the high sensitive detection of MS was used, this experiment, it will provide evidences for elucidation of the effective substance in the water extract of Paeoniae Radix Alba.	Water	177-182	afamin	Homo sapiens	209-213
26991070-2	2016	Os(VIII) complexes that contain water ligands are thermodynamically unfavoured w.r.t.	Water	32-37	cytochrome c oxidase subunit 8A	Homo sapiens	0-8
23558312-4	2013	CO2 and H2O were also directly identified at low temperature by vibrational analysis of the irradiated SAMs.	Water	8-11	methionine adenosyltransferase 1A	Homo sapiens	103-107
27071544-2	2016	This work is focused on the formation of highly functioning barrier films based on nanocrystals (NCs) of a water-scavenging metal-organic framework (MOF) and a hydrophobic cyclic olefin copolymer (COC) to overcome the current limitations.	Water	107-112	lysine acetyltransferase 8	Homo sapiens	124-153
23523120-0	2013	Water concentrations of PAH, PCB and OCP by using semipermeable membrane devices and sediments.	Water	0-5	phenylalanine hydroxylase	Homo sapiens	24-27
23531592-3	2013	In this work, a water soluble copolymer flocculant, STC-g-PDMC (starch-graft-poly (2-methacryloyloxyethyl) trimethyl ammonium chloride) was synthesized through grafting a monomer, (2-methacryloyloxyethyl) trimethyl ammonium chloride (DMC), onto starch initiated by potassium persulphate.	Water	16-21	stanniocalcin 1	Homo sapiens	52-55
26873366-10	2016	In this research, by taking advantage of the supermolecular interactions between amphiphilic graft polyphosphazene and cholesterol which was linked to aptamer AS1411, we prepared a targeted functional polymersome (PEP-DOX HCl-Ap) through a simple method with high loading of water soluble anti-cancer drug doxorubicin hydrochloride.	Water	275-280	prolyl endopeptidase	Mus musculus	214-217
23614742-3	2013	Tobacco smoke contains more than 3800 constituents, including numerous water-insoluble polycyclic aromatic hydrocarbons (PAHs) that trigger aryl hydrocarbon receptor (AhR) signalling pathways.	Water	71-76	aryl hydrocarbon receptor	Homo sapiens	167-170
23051849-7	2013	Expiratory Ptp became negative in all subjects when PEEP decreased below 8.9 +- 5.2 cm H2O.	Water	87-90	protein tyrosine phosphatase receptor type U	Homo sapiens	11-14
27068326-2	2016	Here, we present a combined theoretical/experimental study which provides a quantitative, molecular-level understanding of the ubiquitous and important CaF2/water interface.	Water	157-162	CCR4-NOT transcription complex subunit 8	Homo sapiens	152-156
23556419-5	2013	The crystal structure of the silver(I)-cysteine compound (NH4)Ag2(HCys)(Cys) H2O (1) precipitating at pH ~10 was solved and showed a layer structure with both AgS3 and AgS3N coordination to the cysteinate ligands.	Water	77-80	G protein signaling modulator 1	Homo sapiens	159-163
23557586-1	2013	The reaction of the multisite coordination ligand (LH4) with CoX2 nH2O in the presence of tetrabutylammonium hydroxide affords a series of homometallic dinuclear mixed-valence complexes, [Co(III)Co(II)(LH2)2(X)(H2O)](H2O)m (1, X = Cl and m = 4; 2, X = Br and m = 4; 3, X = NO3 and m = 3).	Water	67-70	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	202-205
23458248-8	2013	Following phosphoryl transfer, Mg2 recruits a water molecule to retain an octahedral coordination geometry suggesting the strong binding character of this magnesium ion, and Mg2 remains in the active site following complete phosphoryl transfer while Mg1 is expelled.	Water	46-51	mucin 7, secreted	Homo sapiens	31-34
23458248-8	2013	Following phosphoryl transfer, Mg2 recruits a water molecule to retain an octahedral coordination geometry suggesting the strong binding character of this magnesium ion, and Mg2 remains in the active site following complete phosphoryl transfer while Mg1 is expelled.	Water	46-51	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	250-253
23355472-6	2013	We observe a magnesium-water cluster in the APE1 active site, with only Glu-96 forming the direct protein coordination to the Mg(2+).	Water	23-28	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	44-48
23467353-5	2013	Mice expressing Galphao RGSi subunits exhibited a naltrexone-sensitive enhancement of baseline latency in both the hot-plate and warm-water tail-withdrawal tests.	Water	134-139	guanine nucleotide binding protein, alpha O	Mus musculus	16-23
22398203-13	2013	A marked increase in COX-2 indicates that it may be an important factor in reducing renal handling of sodium and water in response to PUUO.	Water	113-118	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	21-26
23260251-5	2013	Due to PAH annual fluxes through air-water exchange, Kenting seawater is a source of low molecular weight PAHs and a reservoir of high molecular weight PAHs.	Water	37-42	phenylalanine hydroxylase	Homo sapiens	7-10
23755681-0	2013	Gripe water as reducing and stabilizing agent for synthesis of size controlled gold nanoparticles.	Water	6-11	Ral GTPase activating protein catalytic subunit alpha 1	Homo sapiens	0-5
23755681-2	2013	Herein we report a new approach to synthesize gold nanoparticles (AuNPs) using gripe water as a reducing as well as stabilizing agent.	Water	85-90	Ral GTPase activating protein catalytic subunit alpha 1	Homo sapiens	79-84
23544210-0	2013	Retraction notice to Desalted deep-sea water improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus.	Water	39-44	insulin-like growth factor 1	Mus musculus	113-141
23295905-9	2013	Administration of ghrelin only in the acute hypoxia group significantly (P&lt;0.001) reduced brain water content.	Water	99-104	ghrelin and obestatin prepropeptide	Rattus norvegicus	18-25
23141842-8	2013	The bioavailable fraction of PAH was inversely correlated to the number of benzene rings and the octanol-water partition coefficient.	Water	105-110	phenylalanine hydroxylase	Homo sapiens	29-32
22983654-0	2013	Cyclo-hexa-peptides at the water/cyclohexane interface: a molecular dynamics simulation.	Water	27-32	beta-hexosaminidase subunit alpha	Equus caballus	6-10
22983654-1	2013	Molecular dynamic (MD) simulations have been performed to study the behaviors of ten kinds of cyclo-hexa-peptides (CHPs) composed of amino acids with the diverse hydrophilic/hydrophobic side chains at the water/cyclohexane interface.	Water	205-210	beta-hexosaminidase subunit alpha	Equus caballus	100-104
22834954-10	2013	Additionally, the expression level of Htr3a in the DMSTR was 1.43-fold higher in alcohol-drinking mice than in water-drinking mice (p = 0.044).	Water	111-116	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	38-43
23503468-8	2013	The theoretical findings are supported by atomic-resolution images of mica in water acquired with AM, FM and DAM under similar operating conditions.	Water	78-83	MHC class I polypeptide-related sequence A	Homo sapiens	70-74
22819876-4	2013	Unfortunately, H(2)O(2) is poorly reactive in chemical terms and the second order rate constants for the H(2)O(2)-mediated PTP inactivation are ~10M(-1)s(-1), which is too slow to be compatible with the transient signaling events occurring at the physiological concentrations of H(2)O(2).	Water	15-20	protein tyrosine phosphatase receptor type U	Homo sapiens	123-126
23176753-3	2013	Dicarba bridges were rationally introduced into minimized analogs of GAL and NPY resulting in increased alpha-helical content, in vitro metabolic stability and n-octanol/water partitioning coefficient (logD).	Water	170-175	neuropeptide Y	Mus musculus	77-80
23445506-6	2013	MD simulations were performed on vinculin tail protein both in water and in vacuo environments.	Water	63-68	vinculin	Homo sapiens	33-41
24069046-6	2013	Deep sea water-treated BMSCs showed stronger osteogenic differentiation such as BMP2, RUNX2, OPN, and OCN, and enhanced colony forming abilities, compared to the control group.	Water	9-14	secreted phosphoprotein 1	Mus musculus	93-96
23589719-2	2013	In vitro, the GLP-1 secretion in STC-1, a murine enteroendocrine cell line, was dose dependently stimulated by water extract (WE), its fractions (WEL, &gt;3 kD and WES, &lt;3 kD), and a bitter compounds-rich fraction of BG.	Water	111-116	glucagon	Mus musculus	14-19
23589719-2	2013	In vitro, the GLP-1 secretion in STC-1, a murine enteroendocrine cell line, was dose dependently stimulated by water extract (WE), its fractions (WEL, &gt;3 kD and WES, &lt;3 kD), and a bitter compounds-rich fraction of BG.	Water	111-116	stanniocalcin 1	Mus musculus	33-38
23199524-0	2013	Changes in water channel aquaporin 1 and aquaporin 5 in the small airways and the alveoli in a rat asthma model.	Water	11-16	aquaporin 1	Rattus norvegicus	25-36
23182974-5	2013	Based on single crystal structure, AMG 222 is a pentahydrate with the water molecules sitting in channels formed by the drug framework.	Water	70-75	amelogenin X-linked	Homo sapiens	35-38
23261438-0	2013	Water fluxes through aquaporin-9 prime epithelial cells for rapid wound healing.	Water	0-5	aquaporin 9	Canis lupus familiaris	21-32
22740084-7	2013	Next, the in vivo effects of HA4 on the water content of the SC and transepidermal water loss (TEWL) were investigated.	Water	40-45	keratin 33B	Mus musculus	29-32
22740084-10	2013	However, the water content of the SC was increased in the HA4 group than that of the control group in the non-UVA irradiation groups.	Water	13-18	keratin 33B	Mus musculus	58-61
22740084-11	2013	In addition, the water content of the SC was increased and TEWL and epidermal thickness were decreased in the HA4 group than those of the control and HA groups.	Water	17-22	keratin 33B	Mus musculus	110-113
23039043-1	2013	NO (nitric oxide) is described as an inhibitor of plant and mammalian respiratory chains owing to its high affinity for COX (cytochrome c oxidase), which hinders the reduction of oxygen to water.	Water	189-194	cytochrome c oxidase subunit 8A	Homo sapiens	120-123
24429815-4	2013	Cell exposure to solutions containing NH3/NH4(+) elicits changes in intracellular pH (pHi), which can in turn affect cell water volume (CWV) by activating transport mechanisms that produce net gain or loss of solutes and water.	Water	122-127	glucose-6-phosphate isomerase	Homo sapiens	82-84
23116398-4	2013	It is now generally accepted that XOR transfers the water-exchangeable -OH ligand of the molybdenum atom to the substrate.	Water	52-57	xanthine dehydrogenase	Homo sapiens	34-37
23479768-1	2013	Guanylin (GN), uroguanylin (UGN) and the GC-C receptor have been associated with two endocrine axes: the salt and water homeostasis regulating enterorenal axis and the recently described appetite-regulating UGN/GC-C extraintestinal axis.	Water	114-119	guanylate cyclase activator 2b (retina)	Mus musculus	15-26
23479768-1	2013	Guanylin (GN), uroguanylin (UGN) and the GC-C receptor have been associated with two endocrine axes: the salt and water homeostasis regulating enterorenal axis and the recently described appetite-regulating UGN/GC-C extraintestinal axis.	Water	114-119	guanylate cyclase activator 2b (retina)	Mus musculus	28-31
22899094-1	2013	PURPOSE: Aquaporin 7 (AQP7) belongs to the aquaglyceroporin family, which transports glycerol and water.	Water	98-103	aquaporin 7	Homo sapiens	9-20
22899094-1	2013	PURPOSE: Aquaporin 7 (AQP7) belongs to the aquaglyceroporin family, which transports glycerol and water.	Water	98-103	aquaporin 7	Homo sapiens	22-26
23184379-1	2013	Water and sodium retention precedes the development of high blood pressure (BP) and explains a compensatory rise in B-type natriuretic peptide (BNP) concentrations.	Water	0-5	natriuretic peptide B	Homo sapiens	116-142
23184379-1	2013	Water and sodium retention precedes the development of high blood pressure (BP) and explains a compensatory rise in B-type natriuretic peptide (BNP) concentrations.	Water	0-5	natriuretic peptide B	Homo sapiens	144-147
24094539-13	2013	The trait %CY(WATER) showed a highly positive genetic correlation with %CY(SOLIDS) (0.87), whereas their phenotypic correlation was moderate (0.37), and the fat and protein contents of milk showed high genetic correlations with %CY traits.	Water	14-19	Crystallin	Drosophila melanogaster	11-13
24094539-13	2013	The trait %CY(WATER) showed a highly positive genetic correlation with %CY(SOLIDS) (0.87), whereas their phenotypic correlation was moderate (0.37), and the fat and protein contents of milk showed high genetic correlations with %CY traits.	Water	14-19	Crystallin	Drosophila melanogaster	72-74
24094539-13	2013	The trait %CY(WATER) showed a highly positive genetic correlation with %CY(SOLIDS) (0.87), whereas their phenotypic correlation was moderate (0.37), and the fat and protein contents of milk showed high genetic correlations with %CY traits.	Water	14-19	Crystallin	Drosophila melanogaster	72-74
25464709-3	2013	Water quality indices based on four parameters (pH, DO, BOD and FC) calculated for all the sites were found to be medium to good, good to excellent and bad using modified NSF index.	Water	0-5	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	171-174
22829048-8	2013	THM levels were significantly correlated between different matrices (e.g. dibromochloromethane levels) in water and air (r=0.941); blood and water (r=0.845); and blood and air (r=0.831).	Water	106-111	THM	Homo sapiens	0-3
22829048-8	2013	THM levels were significantly correlated between different matrices (e.g. dibromochloromethane levels) in water and air (r=0.941); blood and water (r=0.845); and blood and air (r=0.831).	Water	141-146	THM	Homo sapiens	0-3
22829048-9	2013	The slopes of best-fit lines for THM levels in water vs air and blood vs air increased with increasing partition coefficient of water/air and blood/air.	Water	47-52	THM	Homo sapiens	33-36
22829048-9	2013	The slopes of best-fit lines for THM levels in water vs air and blood vs air increased with increasing partition coefficient of water/air and blood/air.	Water	128-133	THM	Homo sapiens	33-36
22829048-10	2013	The slope of the correlation plot of THM levels in water vs air decreased in a linear (r=0.995) fashion with increasing Henry"s law constant.	Water	51-56	THM	Homo sapiens	37-40
23053802-5	2013	The longer polypeptides (ELP2 and ELP4) also displayed higher specific dissipation values indicating that they established films with greater structural flexibility and associated water content than the shorter polypeptide, ELP1.	Water	180-185	elongator acetyltransferase complex subunit 4	Homo sapiens	34-38
23823914-5	2013	The muE was well-stabilized at pressures &gt; 210 bar and temperatures &gt; 55  C. At 75  C and 370 bar, SIS1 was found by spectral measurements using a water-soluble UV-light absorber to solubilize water contents up to a maximum water-to-surfactant molar ratio (W0) = 50.	Water	153-158	DnaJ heat shock protein family (Hsp40) member B1	Homo sapiens	105-109
23823914-5	2013	The muE was well-stabilized at pressures &gt; 210 bar and temperatures &gt; 55  C. At 75  C and 370 bar, SIS1 was found by spectral measurements using a water-soluble UV-light absorber to solubilize water contents up to a maximum water-to-surfactant molar ratio (W0) = 50.	Water	199-204	DnaJ heat shock protein family (Hsp40) member B1	Homo sapiens	105-109
23823914-5	2013	The muE was well-stabilized at pressures &gt; 210 bar and temperatures &gt; 55  C. At 75  C and 370 bar, SIS1 was found by spectral measurements using a water-soluble UV-light absorber to solubilize water contents up to a maximum water-to-surfactant molar ratio (W0) = 50.	Water	199-204	DnaJ heat shock protein family (Hsp40) member B1	Homo sapiens	105-109
23823917-6	2013	The Stokes equation predicts that the sedimentation velocity of water droplets dispersed in a continuous silicone oil phase simply depends on the expression (rho - rho0)/eta assuming that the droplet size is constant (where rho is the density of the dispersed water phase, rho0 is the density of the continuous silicone oil phase, and eta is the viscosity of the oil phase).	Water	64-69	endothelin receptor type A	Homo sapiens	170-173
23823917-6	2013	The Stokes equation predicts that the sedimentation velocity of water droplets dispersed in a continuous silicone oil phase simply depends on the expression (rho - rho0)/eta assuming that the droplet size is constant (where rho is the density of the dispersed water phase, rho0 is the density of the continuous silicone oil phase, and eta is the viscosity of the oil phase).	Water	64-69	endothelin receptor type A	Homo sapiens	335-338
23823917-6	2013	The Stokes equation predicts that the sedimentation velocity of water droplets dispersed in a continuous silicone oil phase simply depends on the expression (rho - rho0)/eta assuming that the droplet size is constant (where rho is the density of the dispersed water phase, rho0 is the density of the continuous silicone oil phase, and eta is the viscosity of the oil phase).	Water	260-265	endothelin receptor type A	Homo sapiens	170-173
23573940-6	2013	The alkalinity of water also helps in mobilizing fluoride from fluorite (CaF2).	Water	18-23	CCR4-NOT transcription complex subunit 8	Homo sapiens	73-77
23565247-4	2013	Long-term treatment with a ghrelin agonist was sufficient to improve the performance in the water maze.	Water	92-97	ghrelin	Mus musculus	27-34
23382902-10	2013	Aquaporin-10 silencing in human differentiated adipocytes resulted in a 50% decrease of glycerol and osmotic water permeability.	Water	109-114	aquaporin 10	Homo sapiens	0-12
23234602-3	2012	The SAMs exhibit excellent hydrophobicity, with static water contact angles of up to 119  and low critical surface tensions of 5-20 mN/m depending on the number of F atoms per molecule.	Water	55-60	methionine adenosyltransferase 1A	Homo sapiens	4-8
23555924-5	2013	The activity of P450arom was addressed by the tritiated water release assay and the expression of Cyp19 gene was evaluated by Western blotting and real time RT-PCR.	Water	56-61	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	16-24
26774574-1	2016	In this study, we develop a facile one-pot approach to the fabrication of poly(L-lactic acid) (PLLA) microsphere-incorporated calcium alginate (ALG-Ca)/hydroxyapatite (HAp) porous scaffolds based on HAp nanoparticle-stabilized oil-in-water Pickering emulsion templates, which contain alginate in the aqueous phase and PLLA in the oil phase.	Water	234-239	retinoic acid receptor, beta	Mus musculus	168-171
23129151-1	2012	Active in alkaline environment: The activity of nickel, silver, and copper catalysts for the electrochemical transformation of water to molecular hydrogen in alkaline solutions was enhanced by modification of the metal surfaces by Ni(OH)(2) (see picture; I = current density and eta = overpotential).	Water	127-132	endothelin receptor type A	Homo sapiens	214-217
26868103-0	2016	Ecological interactions and the fitness effect of water-use efficiency: Competition and drought alter the impact of natural MPK12 alleles in Arabidopsis.	Water	50-55	mitogen-activated protein kinase 12	Arabidopsis thaliana	124-129
23227925-8	2012	Antioxidant (EUK-8) and p38 MAPK inhibitor (SB202190) treatment attenuated the increase in caspase-3 activity, cell death and WDR35 expression induced by bupivacaine or H(2)O(2).	Water	169-174	mitogen-activated protein kinase 14	Mus musculus	24-32
23476269-0	2012	Adipic acid-2,6-bis-(1H-benzimidazol-2-yl)pyridine-water (1/2/4).	Water	51-56	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	7-13
24171321-1	2013	Cytochrome c oxidase (COX) employs electrons obtained from cytochrome c to bring about the reduction of oxygen to water.	Water	114-119	LOC104968582	Bos taurus	0-12
24171321-1	2013	Cytochrome c oxidase (COX) employs electrons obtained from cytochrome c to bring about the reduction of oxygen to water.	Water	114-119	LOC104968582	Bos taurus	59-71
23140329-1	2012	Prior studies have shown that the biological mixture of the two hydrophobic surfactant proteins, SP-B and SP-C, produces faster adsorption of the surfactant lipids to an air/water interface, and that they induce 1-palmitoyl-2-oleoyl phosphatidylethanolamine (POPE) to form inverse bicontinuous cubic phases.	Water	174-179	surfactant protein B	Homo sapiens	97-101
26850817-1	2016	In the present work, we prepared memantine-pamoic acid (MEM-PAM) salt by counter ion exchange in the aqueous phase to reduce the water solubility of MEM hydrochloride (native form) to make it suitable for long acting injection.	Water	129-134	peptidylglycine alpha-amidating monooxygenase	Mus musculus	60-63
23108657-10	2012	Reduction of intestinal sodium absorption by selective NHE3 inhibition in the gut reduces high blood pressure and increases feces water excretion.	Water	130-135	solute carrier family 9 member A3	Rattus norvegicus	55-59
23104155-4	2012	The nature of peptides enables their assemblies to be reconfigured at the water/MOF interface, and thus converted to fuel energy.	Water	74-79	lysine acetyltransferase 8	Homo sapiens	80-83
26935263-8	2016	Compared with the SAH group, the level of AQP4 and the cerebral content of water was significantly decreased (P&lt;0.01) by atorvastatin, and TUNEL staining and studying the expression of caspase-3 showed that the apoptosis of neurons was reduced markedly both in the hippocampus and brain cortex by atorvastatin.	Water	75-80	caspase-3	Oryctolagus cuniculus	188-197
23036579-0	2012	Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-kappaB pathways.	Water	0-5	mitogen-activated protein kinase 14	Mus musculus	98-106
27043552-3	2016	The aim of this study was to determine whether changes in the expressions of ERRalpha, Na+/K+-ATPase and epithelial sodium channel (ENaC) proteins affected the reabsorption of water and sodium in kidneys of Dahl salt-sensitive (DS) rats.	Water	176-181	estrogen related receptor, alpha	Rattus norvegicus	77-85
23247390-3	2012	In this study, we investigate the displacement of water molecules by an apolar probe in the binding pocket of two proteins, cyclin-dependent kinase 2 and tRNA-guanine transglycosylase, using the method of enveloping distribution sampling (EDS) to obtain free enthalpy differences.	Water	50-55	cyclin dependent kinase 2	Homo sapiens	124-149
22806408-2	2012	METHODS: Water-in-oil-in-water (W/O/W) multiple emulsion-based multi-compartmental vaccine delivery system containing the gp100 peptide was prepared by a two-step emulsification method.	Water	9-14	premelanosome protein	Mus musculus	122-127
22806408-2	2012	METHODS: Water-in-oil-in-water (W/O/W) multiple emulsion-based multi-compartmental vaccine delivery system containing the gp100 peptide was prepared by a two-step emulsification method.	Water	25-30	premelanosome protein	Mus musculus	122-127
26841230-4	2016	Outdoor solar photolysis experiments were performed to investigate photolytic degradation of the total organic halogen (TOX) formed by fulvic acid and real water and wastewater samples.	Water	156-161	thymocyte selection associated high mobility group box	Homo sapiens	120-123
23052011-1	2012	Using the omegaB97X-D and B3LYP density functionals, the absolutely localized molecular orbital energy decomposition method (ALMO-EDA) is applied to the water dimer through pentamer, 13-mer and 17-mer clusters.	Water	153-158	ectodysplasin A	Homo sapiens	130-133
26575718-5	2016	The monolayer moisture content, obtained by the BET equation, significantly increased during storage from 1.473 to 2.080 g water 100 g db(-1), probably because of the increase in the active sites for water binding due to the chemical and physical changes of the main components, induced by product ageing.	Water	123-128	delta/notch like EGF repeat containing	Homo sapiens	48-51
23058106-3	2012	The flexible docking results are in good agreement with the crystal structures of four exemplar benzimidazole ligands bound to CHK2 which unambiguously confirmed the binding mode of these inhibitors, including the water-mediated interaction with the hinge region, and which is significantly different from binding modes previously postulated in the literature.	Water	214-219	checkpoint kinase 2	Homo sapiens	127-131
23011948-3	2012	The corresponding water-soluble supramolecular 1:1 host-guest beta-cyclodextrin (beta-CD) adducts ((R/S)-(1-4) beta-CD 2 NO(3)) were also prepared and fully characterised.	Water	18-23	retinoschisin 1	Homo sapiens	99-109
23122813-4	2012	FS in cold water also induced phosphorylation of mitogen-activated protein kinase kinase (MEK) as well as of cAMP response element-binding protein (CREB), or dephosphorylation of alpha isoform of Ca(2+)/calmodulin-dependent protein kinase II (alphaCaMKII) in the hippocampus.	Water	11-16	midkine	Mus musculus	49-88
23122813-4	2012	FS in cold water also induced phosphorylation of mitogen-activated protein kinase kinase (MEK) as well as of cAMP response element-binding protein (CREB), or dephosphorylation of alpha isoform of Ca(2+)/calmodulin-dependent protein kinase II (alphaCaMKII) in the hippocampus.	Water	11-16	midkine	Mus musculus	90-93
23058106-2	2012	Unconstrained rigid docking of benzimidazole ligands into representative CHK2 protein crystal structures reveals an alternative binding mode involving a water-mediated interaction with the hinge region; docking which incorporates protein side chain flexibility for selected residues in the ATP binding site resulted in a refinement of the water-mediated hinge binding mode that is consistent with observed SAR.	Water	153-158	checkpoint kinase 2	Homo sapiens	73-77
23058106-2	2012	Unconstrained rigid docking of benzimidazole ligands into representative CHK2 protein crystal structures reveals an alternative binding mode involving a water-mediated interaction with the hinge region; docking which incorporates protein side chain flexibility for selected residues in the ATP binding site resulted in a refinement of the water-mediated hinge binding mode that is consistent with observed SAR.	Water	339-344	checkpoint kinase 2	Homo sapiens	73-77
22995181-3	2012	It was shown that (1) Preconditioning with H(2)O(2) at 100 mumol/L for 90 min in PC12 cells induced significant expression of iNOS and COX-2.	Water	43-48	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	135-140
22565543-2	2012	In all solvents, the activity of catalase is smaller than in water.	Water	61-66	catalase	Bos taurus	33-41
26575718-5	2016	The monolayer moisture content, obtained by the BET equation, significantly increased during storage from 1.473 to 2.080 g water 100 g db(-1), probably because of the increase in the active sites for water binding due to the chemical and physical changes of the main components, induced by product ageing.	Water	200-205	delta/notch like EGF repeat containing	Homo sapiens	48-51
26856700-5	2016	Our results showed that the effective time to administer a single dose of ADA to suppress induction of EAU was 8-14 d postimmunization, shortly before EAU expression; however, ADA treatment at other time points exacerbated disease.	Water	103-106	adenosine deaminase	Mus musculus	74-77
23323418-4	2012	Results show, four kinds of input water ratio have varying degrees COD and SS removal efficiency, however, input water ratio for 1 : 1 can substantially increase SCOD/COD ratio and VFA concentration of effluent water compared with the other three input water ratios.	Water	34-39	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	67-70
23323418-4	2012	Results show, four kinds of input water ratio have varying degrees COD and SS removal efficiency, however, input water ratio for 1 : 1 can substantially increase SCOD/COD ratio and VFA concentration of effluent water compared with the other three input water ratios.	Water	34-39	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	163-166
23323418-4	2012	Results show, four kinds of input water ratio have varying degrees COD and SS removal efficiency, however, input water ratio for 1 : 1 can substantially increase SCOD/COD ratio and VFA concentration of effluent water compared with the other three input water ratios.	Water	113-118	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	163-166
23323418-4	2012	Results show, four kinds of input water ratio have varying degrees COD and SS removal efficiency, however, input water ratio for 1 : 1 can substantially increase SCOD/COD ratio and VFA concentration of effluent water compared with the other three input water ratios.	Water	113-118	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	163-166
26922388-7	2016	The life span of Gulo-/- mice increased with the amount of ascorbate in drinking water.	Water	81-86	gulonolactone (L-) oxidase	Mus musculus	17-21
23323418-4	2012	Results show, four kinds of input water ratio have varying degrees COD and SS removal efficiency, however, input water ratio for 1 : 1 can substantially increase SCOD/COD ratio and VFA concentration of effluent water compared with the other three input water ratios.	Water	113-118	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	163-166
22587785-2	2012	5, 7, and 10 mer peptides (Leu-enkephalinamide, dermorphinamide, and a typical difficult sequence, ACP (65-74) peptide) were successfully synthesized in water according to Fmoc chemistry using water-dispersible nanoparticles with microwave irradiation.	Water	153-158	CPAT1	Homo sapiens	99-102
22587785-2	2012	5, 7, and 10 mer peptides (Leu-enkephalinamide, dermorphinamide, and a typical difficult sequence, ACP (65-74) peptide) were successfully synthesized in water according to Fmoc chemistry using water-dispersible nanoparticles with microwave irradiation.	Water	193-198	CPAT1	Homo sapiens	99-102
23115189-7	2012	The ROS-triggered transactivation of TrkB exerts neuroprotective effects, because inhibition of TrkB kinase activity or uncoupling Shc signaling from TrkB exacerbates neuronal cell death induced by H(2)O(2).	Water	198-203	neurotrophic receptor tyrosine kinase 2	Homo sapiens	37-41
22914759-0	2012	Synthesis, crystal structure and thermal properties of Ca6(C12H14O4)4(CO3)(OH)2(H2O)x--a 3D inorganic hybrid material.	Water	80-83	carbonic anhydrase 6	Homo sapiens	55-58
26879265-6	2016	In our observations, substituted V20 of Rab11A was found to interfere with proper localization of the water molecule, which mediated GTP hydrolysis, resulting in GTP being locked in an active form of Rab11A S20V.	Water	102-107	RAB11A, member RAS oncogene family	Homo sapiens	40-46
22988974-5	2012	Fluorescence quenching and electron paramagnetic resonance (EPR) studies showed that water-soluble rosmarinic acid (R0) exhibited more interactions with alpha-tocopherol than any of the tested esters (R4, R12, R20).	Water	85-90	G protein-coupled receptor 17	Homo sapiens	205-208
22925980-0	2012	Molecular structure, natural bond analysis, vibrational, and electronic spectra of aspartateguanidoacetatenickel(II), [Ni(Asp)(GAA)] H2O: DFT quantum mechanical calculations.	Water	133-136	alpha glucosidase	Homo sapiens	127-130
26879265-6	2016	In our observations, substituted V20 of Rab11A was found to interfere with proper localization of the water molecule, which mediated GTP hydrolysis, resulting in GTP being locked in an active form of Rab11A S20V.	Water	102-107	RAB11A, member RAS oncogene family	Homo sapiens	200-206
22683765-5	2012	Repeated water immersion stress for 1 and 2 weeks decreased colonic Muc2 gene levels to 40% of that of non-stressed animals, while exposure to stress for 3 days induced only a 25% decrease.	Water	9-14	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	68-72
22683765-0	2012	Repeated exposure to water immersion stress reduces the Muc2 gene level in the rat colon via two distinct mechanisms.	Water	21-26	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	56-60
28875648-1	2016	Salvianolic acid A (SAA), one of the major active water-soluble salvianolic acids of traditional Chinese medicine Salvia miltiorrhiza Bunge, has been reported to be effective on anti-myocardial ischemia, anti-oxidation and anti-thrombus.	Water	50-55	serum amyloid A1	Canis lupus familiaris	20-23
23720263-4	2012	The classic RAS can be defined as the ACE-Ang II-AT1R axis that promotes vasoconstriction, water intake, sodium retention, and other mechanisms to maintain blood pressure, as well as increase oxidative stress, fibrosis, cellular growth, and inflammation in pathological conditions.	Water	91-96	angiogenin	Homo sapiens	42-45
23720263-4	2012	The classic RAS can be defined as the ACE-Ang II-AT1R axis that promotes vasoconstriction, water intake, sodium retention, and other mechanisms to maintain blood pressure, as well as increase oxidative stress, fibrosis, cellular growth, and inflammation in pathological conditions.	Water	91-96	angiotensin II receptor type 1	Homo sapiens	49-53
22683765-8	2012	Collectively, the repeated exposure to water immersion stress decreases Muc2 synthesis in the goblet cells via decreased Cdx2 expression and subsequently reduces the goblet cell number via Notch signaling suppression.	Water	39-44	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	72-76
22243807-3	2012	Reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR analyses revealed significant increases in MT1 and MT2 mRNA expression in the hippocampus, following VPA (4 mg/ml drinking water) treatment for 17 d. Increases in the mRNA and protein expression of the novel neurotrophic factors, conserved dopamine neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor, were detected in the hippocampus and/or striatum.	Water	198-203	metallothionein 2A	Rattus norvegicus	126-129
22994915-11	2012	Two STEC O124:H19 strains isolated from rectal swabs and water with a 5-month interval harbored the stx1/stx2/saa/ehxA genotype, and showed an indistinguishable PFGE profile.	Water	57-62	syntaxin 2	Bos taurus	105-109
26721731-5	2016	Testing of 20mg nifedipine capsules in FaSSGFst (Fasted State Simulated Gastric Fluid pH 1.6; water administration) produced IVIVC with the USP3 (after time scaling) and USP4 apparatus.	Water	94-99	ubiquitin specific peptidase 3	Homo sapiens	140-144
22872137-4	2012	The computed reduction potentials of the Co(2+)/Co(+) couple imply that the Co(+)-H(H(2)O) interaction causes a greater anodic shift [5-98 mV vs. the normal hydrogen electrode (NHE) in chloroform solvent] than the analogous Co(+)-H(imidazole) interaction (1 mV vs. NHE) in the reduction potential of the Co(2+)/Co(+) couple.	Water	84-89	solute carrier family 9 member C1	Homo sapiens	177-180
22872137-4	2012	The computed reduction potentials of the Co(2+)/Co(+) couple imply that the Co(+)-H(H(2)O) interaction causes a greater anodic shift [5-98 mV vs. the normal hydrogen electrode (NHE) in chloroform solvent] than the analogous Co(+)-H(imidazole) interaction (1 mV vs. NHE) in the reduction potential of the Co(2+)/Co(+) couple.	Water	84-89	solute carrier family 9 member C1	Homo sapiens	265-268
23039629-18	2012	On a uniform water cylinder phantom, more accurate I(0) suppresses the unfaithful high-frequency signals at the object boundaries of the measured scatter, and the SPR estimation error is reduced from 0.158 to 0.014.	Water	13-18	sepiapterin reductase	Homo sapiens	163-166
26561651-9	2016	Analysis of human urinary exosomes demonstrated that water loading in human subjects significantly reduces the abundance of NCC1/2 in urinary exosomes.	Water	53-58	C-C motif chemokine ligand 13	Homo sapiens	124-128
22803810-6	2012	Compounds such as 9m with water-solubilizing moieties at the para position of the B-ring inhibited the autophosphorylation of Aurora A in MDA-MB-468 breast cancer cells.	Water	26-31	aurora kinase A	Homo sapiens	126-134
22829653-6	2012	Importantly, we show that ACBP(-/-) mice display a ~50% increased transepidermal water loss compared with ACBP(+/+) mice.	Water	81-86	diazepam binding inhibitor	Mus musculus	26-35
22829653-6	2012	Importantly, we show that ACBP(-/-) mice display a ~50% increased transepidermal water loss compared with ACBP(+/+) mice.	Water	81-86	diazepam binding inhibitor	Mus musculus	26-30
26474749-6	2016	The second group was distributed in the bottom water at the coastal side of the bay where considerably high Chl.	Water	47-52	chordin like 1	Homo sapiens	108-111
23076196-0	2012	[Changes of lung, spleen and kidney aquaporin-1 in rats with Kidney Yang Deficiency: the "water metabolism theory" in traditional Chinese medicine].	Water	90-95	aquaporin 1	Rattus norvegicus	36-47
23076196-1	2012	OBJECTIVE: To explore the experimental basis of the "water metabolism theory" in traditional Chinese medicine by observing the changes of aquaporin-1 in the lung, spleen and kidney.	Water	53-58	aquaporin 1	Rattus norvegicus	138-149
23037534-0	2012	Mn-doped GaN as photoelectrodes for the photoelectrolysis of water under visible light.	Water	61-66	gigaxonin	Homo sapiens	9-12
26475588-4	2016	The classic RAS comprises the ACE-ANG II-AT1R axis that promotes vasoconstriction; water intake; sodium retention; and increased oxidative stress, fibrosis, cellular growth, and inflammation.	Water	83-88	angiogenin	Homo sapiens	34-37
22920218-5	2012	To our knowledge, these are the first calculations for inhibitors of the hDM2 system that employ a full treatment of statistical mechanics including explicit water representation and full protein flexibility.	Water	158-163	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	73-77
22796440-5	2012	Administration of N-acetyl-L-cysteine, an antioxidant, in the drinking water improved these protein expressions in the skin of Flg(ft) mice.	Water	71-76	filaggrin	Mus musculus	127-130
23073632-1	2012	The neurohypophysial hormone arginine vasopressin (AVP) is essential for a wide range of physiological functions, including water reabsorption, cardiovascular homeostasis, hormone secretion, and social behavior.	Water	124-129	arginine vasopressin	Mus musculus	51-54
26475588-4	2016	The classic RAS comprises the ACE-ANG II-AT1R axis that promotes vasoconstriction; water intake; sodium retention; and increased oxidative stress, fibrosis, cellular growth, and inflammation.	Water	83-88	angiotensin II receptor type 1	Homo sapiens	41-45
23289156-2	2012	In order to establish an in vitro estrogen-like compound screening model, the coding region of human ERalpha and ERbeta was separately constructed into pET32-ERalpha and pET43-ERbeta prokaryotic expression vector and water-soluble recombinant ERalpha and ERbeta proteins were expressed in Escherichia coli strain BL21.	Water	217-222	estrogen receptor 2	Homo sapiens	113-119
27251497-5	2016	It has been reported that DNA polymerase eta is unable to exclude water molecules from the active site.	Water	66-71	DNA polymerase eta	Homo sapiens	26-44
23290760-7	2012	RESULTS: (1) The water-absorbing rate at PIH 24 of Allevyn foam dressing, Mepilex foam dressing, and Biatain foam dressing were respectively (646 +- 18)%, (616 +- 19)%, and (499 +- 11)% (F = 423.854, P &lt; 0.01).	Water	17-22	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	41-44
24751076-0	2012	A phenomenological and thermodynamic study of the water permeation process in corn starch/MMT films.	Water	50-55	methionine S-methyltransferase	Zea mays	90-93
27965975-0	2016	Comparison of Extended-Spectrum beta-Lactamase-Producing Escherichia coli Isolates from Drinking Well Water and Pit Latrine Wastewater in a Rural Area of China.	Water	102-107	beta-lactamase	Escherichia coli	32-46
22749806-1	2012	The mineralocorticoid receptor (MR) plays an important role in salt and water homeostasis and pathological tissue modifications, such as cardiovascular and renal fibrosis.	Water	72-77	nuclear receptor subfamily 3 group C member 2	Homo sapiens	4-30
22749806-1	2012	The mineralocorticoid receptor (MR) plays an important role in salt and water homeostasis and pathological tissue modifications, such as cardiovascular and renal fibrosis.	Water	72-77	nuclear receptor subfamily 3 group C member 2	Homo sapiens	32-34
22858721-4	2012	The results suggested that bromide anion directly participates in the acid hydrolysis reaction of MGP in a water solvent system and the participation of bromide anion is further pronounced in aqueous 74% and 82% 1,4-dioxane solvent systems.	Water	107-112	matrix Gla protein	Homo sapiens	98-101
27965975-1	2016	The present study was conducted to gain insights into the occurrence and characteristics of extended-spectrum beta-lactamase- (ESBL-) producing Escherichia coli (E. coli) from drinking well water in the rural area of Laiwu, China, and to explore the role of the nearby pit latrine as a contamination source.	Water	190-195	beta-lactamase	Escherichia coli	110-124
22949654-0	2012	The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates.	Water	91-96	NADH-ubiquinone reductase (H(+)-translocating) NDI1	Saccharomyces cerevisiae S288C	47-51
27191606-7	2016	Then, we present the relationship between the TRPV1 channel and spontaneous locomotor activity, physical performance, and modulation of several physiological responses, including water and electrolyte balance, muscle hypertrophy, and metabolic, cardiovascular, gastrointestinal, and inflammatory responses.	Water	179-184	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
22674028-4	2012	Consequently, we hypothesized that the water channel aquaporin-1 (AQP1) facilitates water flux across the basolateral membrane of TALs.	Water	39-44	aquaporin 1	Rattus norvegicus	66-70
22674028-10	2012	Water flux was decreased by ~50% in Aqp1 knockout mice compared with wild-types (4.0 +- 0.8 vs. 8.9 +- 1.7 fluorescent U/s, P &lt; 0.02; n = 7).	Water	0-5	aquaporin 1	Mus musculus	36-40
22674028-12	2012	We conclude that 1) the TAL expresses AQP1, 2) ~23% of the total pool of AQP1 is localized to the basolateral membrane, 3) AQP1 mediates a significant portion of basolateral water flux, and 4) AQP1 is upregulated in TALs of rats infused with dDAVP.	Water	174-179	aquaporin 1	Rattus norvegicus	73-77
22775299-0	2012	Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: mass spectrometric evidence for the presence of a trapped water molecule.	Water	152-157	cytidine deaminase	Homo sapiens	12-30
22742766-0	2012	An active site water broadens substrate specificity in S-ribosylhomocysteinase (LuxS): a docking, MD, and QM/MM study.	Water	15-20	Lutheran suppressor, X-linked	Homo sapiens	80-84
22622462-8	2012	When water deprived, TG mice failed to adequately concentrate urine and exhibited impaired AVP responses.	Water	5-10	arginine vasopressin	Mus musculus	91-94
27871077-9	2016	Water intake was slightly but significantly higher in Anx7-/- mice than in Anx7+/+ mice.	Water	0-5	annexin A7	Mus musculus	54-58
22622462-11	2012	We also note impaired AVP release in response to water deprivation but that TG kidneys are responsive to exogenous dDAVP or AVP.	Water	49-54	arginine vasopressin	Mus musculus	22-25
22674028-12	2012	We conclude that 1) the TAL expresses AQP1, 2) ~23% of the total pool of AQP1 is localized to the basolateral membrane, 3) AQP1 mediates a significant portion of basolateral water flux, and 4) AQP1 is upregulated in TALs of rats infused with dDAVP.	Water	174-179	aquaporin 1	Rattus norvegicus	73-77
27871077-9	2016	Water intake was slightly but significantly higher in Anx7-/- mice than in Anx7+/+ mice.	Water	0-5	annexin A7	Mus musculus	75-79
22674028-12	2012	We conclude that 1) the TAL expresses AQP1, 2) ~23% of the total pool of AQP1 is localized to the basolateral membrane, 3) AQP1 mediates a significant portion of basolateral water flux, and 4) AQP1 is upregulated in TALs of rats infused with dDAVP.	Water	174-179	aquaporin 1	Rattus norvegicus	73-77
22879717-8	2012	In addition, spa spring water attenuated the differentiation process of subsets of CD4(+) T cells, i.e., Th1, Th2 and Th17 cells.	Water	24-29	surfactant protein A1	Homo sapiens	13-16
25986427-4	2016	RESULTS: Although fat and protein preloads did not alter PE of either solids or liquids, the CAT of solids, but not liquids, was longer than that after the water preload (fat 68 +- 5 min and protein 71 +- 6 min vs. water 46 +- 5 min; P = 0.02).	Water	156-161	FAT atypical cadherin 1	Homo sapiens	171-174
24750936-1	2012	In current study, a water-soluble polysaccharide (GP-I), with a molecular mass of 33 kDa, was purified from Gynostemma pentaphyllum.	Water	20-25	glucose-6-phosphate isomerase	Homo sapiens	50-54
22821882-2	2012	The enzymatic conversion of this probe by beta-galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd(3+) complex to modulate the (1) H MR signal intensity of the surrounding water molecules.	Water	225-230	galactosidase beta 1	Homo sapiens	42-60
26615386-4	2016	In this work, we adapted a model typically used to estimate the photodegradation of organic pollutants, APEX, to explore the fate of two commonly used surrogates of human viruses (coliphages MS2 and phiX174) in waste stabilization pond and natural surface water.	Water	256-261	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	104-108
23904652-3	2012	The effect of drying method on the water sorption isotherms of dried mint samples was evaluated.	Water	35-40	spen family transcriptional repressor	Homo sapiens	69-73
23189723-7	2012	Compared with the normal group, within 7 days after the administration, water extracted components in 0.63-5.0 g x kg(-1) dose scope could cause significant damage to liver, the activity of ALT, AST, AKP, TBI elevated, while ALB reduced, and liver ratio increased, and under light microscope, the different doses" liver tissue of mice all had different degree"s edema, fatty degeneration in liver cells and interstitial congestion.	Water	72-77	albumin	Mus musculus	225-228
26791767-13	2016	EBI3(rs393581, rs4740 and rs353702), FOXP3(rs2280883, rs2232365 and rs3761548)were associated with the improvement of water discharge in nasal signs.	Water	118-123	forkhead box P3	Homo sapiens	37-42
22537808-3	2012	The GC-g-C(60) with 5x10(-4) C(60) molecules per one repeating unit of GC was soluble in water.	Water	89-94	glucagon	Mus musculus	4-8
26573055-3	2015	Upon removal of DMF and H2O solvent molecules, the compound undergoes a slight structural distortion to give the desolvated phase (Me2NH2)2[Fe2L3], and a fit to N2 adsorption data of this activated compound gives a BET surface area of 885(105) m(2)/g.	Water	24-27	delta/notch like EGF repeat containing	Homo sapiens	215-218
22669176-1	2012	New amphiphilic ABC triblock copolymers have been designed and self-assembled into water-dispersible and biodegradable polymer micelles, which exhibit good antibacterial activities without quaternary ammonium moieties or the loading of any external antibiotics due to the increased local concentration of cationic charge in the polymer micelles compared to the un-self-assembled individual polymer chains.	Water	83-88	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	16-19
26592558-2	2015	The higher the conductivity ratio (using very low conductivity sample diluents such as water), the higher the SEF.	Water	87-92	transcription factor CP2	Homo sapiens	110-113
25968479-1	2015	We evaluate the contribution of leptin-dependent anorexigenic pathways and neuropeptide Y (NPY)-dependent orexigenic pathways to the changes in hypothalamic water diffusion parameters observed in vivo by functional diffusion weighted MRI (fDWI).	Water	157-162	neuropeptide Y	Mus musculus	91-94
22716220-4	2012	The results in water, especially the activation entropy (+14 +- 2 J K(-1) mol(-1)) and activation volume (-5.9 +- 0.6 cm(3) mol(-1)), differ significantly from those found for the other solvents.	Water	15-20	keratin 1	Homo sapiens	68-73
22609658-1	2012	A modified method for calculating practical ethanol yield in the simultaneous saccharification and fermentation (SSF) at high lignocellulosic solids content and high ethanol titer is proposed considering the liquid volume change caused by high titer ethanol generation and the water consumed during cellulose degradation.	Water	277-282	peter pan homolog	Homo sapiens	113-116
32262729-3	2015	The results of Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and water contact angle (WCA) measurements confirmed the successful immobilization of Ang-1.	Water	106-111	angiopoietin 1	Homo sapiens	188-193
22526928-5	2012	M2 water treatment up-regulated GRP78 mRNA and protein expression, whereas H water treatment up-regulated mRNA and protein expression of GRP78 and caspase-12.	Water	77-82	caspase 12	Mus musculus	147-157
22526928-7	2012	M1 water exposure up-regulated GRP78 mRNA and protein expression and CHOP mRNA expression, whereas M2 water treatment up-regulated caspase-12 and Bcl-2 mRNA expression.	Water	102-107	caspase 12	Mus musculus	131-141
22580338-4	2012	Upon knockdown of SOD2 by RNA interference, UM1 cells displayed significantly reduced migration and invasion abilities; reduced activities of SOD2; lower intracellular H(2)O(2); decreased protein levels of Snail, MMP1, and pERK1/2; and increased protein levels of E-cadherin.	Water	168-173	superoxide dismutase 2	Homo sapiens	18-22
26447780-5	2015	Density functional theory (DFT) calculations are carried out at the OPBE/TZP level for three representative sizes (n = 6, 9, 13) and indicate that the vibrations responsible for the resonances correspond to bending and torsional modes between the cluster and water moieties.	Water	259-264	PHD finger protein 20	Homo sapiens	73-76
22375892-0	2012	Evidence for a role of endogenous nesfatin-1 in the control of water drinking.	Water	63-68	nucleobindin 2	Rattus norvegicus	34-44
26431706-7	2015	There was also a strong correlation between THM levels and water temperature, contact time and pH.	Water	59-64	THM	Homo sapiens	44-47
22375892-3	2012	In preliminary studies, we observed a decrease in hypothalamic NucB2 expression in response to overnight water deprivation even when food was present, which reversed when water was returned to the animals.	Water	105-110	nucleobindin 2	Rattus norvegicus	63-68
22375892-3	2012	In preliminary studies, we observed a decrease in hypothalamic NucB2 expression in response to overnight water deprivation even when food was present, which reversed when water was returned to the animals.	Water	171-176	nucleobindin 2	Rattus norvegicus	63-68
22375892-4	2012	We therefore hypothesised that the effect of nesfatin-1 on water drinking was independent of its anorexigenic action.	Water	59-64	nucleobindin 2	Rattus norvegicus	45-55
26978928-2	2015	Then water-soluble Cd1-xZnxSe ternary quantum dots with different component were prepared by colloid chemistry.	Water	5-10	CD1c molecule	Homo sapiens	19-22
22419034-7	2012	Overall, these data suggest that increases in AQP1 and NKCC1 expression under hyposmotic stress may be one of the molecular mechanisms underlying the pathophysiology of acute hyponatremia, such as the necrotic cell death of hippocampal CA1 region by increasing water transport across the blood-CSF barrier.	Water	261-266	aquaporin 1	Rattus norvegicus	46-50
22419034-7	2012	Overall, these data suggest that increases in AQP1 and NKCC1 expression under hyposmotic stress may be one of the molecular mechanisms underlying the pathophysiology of acute hyponatremia, such as the necrotic cell death of hippocampal CA1 region by increasing water transport across the blood-CSF barrier.	Water	261-266	solute carrier family 12 member 2	Rattus norvegicus	55-60
26673749-0	2015	Gripe Water Administration in Infants 1-6 months of Age-A Cross-sectional Study.	Water	6-11	Ral GTPase activating protein catalytic subunit alpha 1	Homo sapiens	0-5
22908561-4	2012	The cPLA2 and sPLA2 activities were inhibited in vitro by asiaticoside present in the water extract of C. asiatica.	Water	86-91	phospholipase A2 group IIA	Rattus norvegicus	14-19
26673749-1	2015	INTRODUCTION: Gripe water (GW) administration to young infants is common practice in this part of country.	Water	20-25	Ral GTPase activating protein catalytic subunit alpha 1	Homo sapiens	14-19
26364130-7	2015	The effective molar absorption coefficient at 492 nm for the ZnHx(PAR)2 complex at pH7.4 in buffered water solution is 71,500 M(-1) cm(-1), and the dissociation constant of the complex in these conditions is 7.08x10(-13) M(2).	Water	101-106	F2R like trypsin receptor 1	Homo sapiens	61-71
22726688-1	2012	The mineralocorticoid receptor (MR), a member of the steroid receptor superfamily, regulates water-electrolyte balance and mediates pathophysiological effects in the renocardiovascular system.	Water	93-98	nuclear receptor subfamily 3 group C member 2	Homo sapiens	4-30
22726688-1	2012	The mineralocorticoid receptor (MR), a member of the steroid receptor superfamily, regulates water-electrolyte balance and mediates pathophysiological effects in the renocardiovascular system.	Water	93-98	nuclear receptor subfamily 3 group C member 2	Homo sapiens	32-34
26102520-0	2015	Probing the Mucoadhesive Interactions Between Porcine Gastric Mucin and Some Water-Soluble Polymers.	Water	77-82	LOC100508689	Homo sapiens	62-67
22624583-0	2012	Thermodynamic impact of embedded water molecules in the unfolding of human CD2BP2-GYF domain.	Water	33-38	CD2 cytoplasmic tail binding protein 2	Homo sapiens	75-81
22624583-8	2012	By means of CASTp server, we have found seven cavities/pockets scattered throughout of the CD2BP2-GYF structure, each able to harbor at least one water molecule.	Water	146-151	CD2 cytoplasmic tail binding protein 2	Homo sapiens	91-97
22624583-9	2012	This structural feature provides rationalization for the atypical enthalpy values observed for CD2BP2-GYF because each water molecule is able to organize an extra amount of hydrogen bonds in the native state.	Water	119-124	CD2 cytoplasmic tail binding protein 2	Homo sapiens	95-101
26102520-1	2015	This study investigates the structural features of porcine gastric mucin (PGM) in aqueous dispersions and its interactions with water-soluble polymers (poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), poly(ethylene oxide), and poly(ethylene glycol)) using isothermal titration calorimetry, turbidimetric titration, dynamic light scattering, and transmission electron microscopy.	Water	128-133	LOC100508689	Homo sapiens	67-72
26315345-4	2015	Additionally, aquaporin 1 (AQP1) not only functions as a water channel molecule but also promotes cell migration by facilitating water transport in the lamellipodia of migrating cells.	Water	57-62	aquaporin 1	Rattus norvegicus	14-25
22562405-3	2012	The prepared 3D SrS/CdS exhibited improved photocatalytic activity for water splitting leading to H(2) generation (AQY 10%) and nearly complete degradation of methyl orange (MO) dye.	Water	71-76	Russell-Silver dwarfism	Homo sapiens	16-19
22620702-6	2012	RESULTS: When glucose and leucine were administered to the horses, plasma insulin concentration was significantly higher during the 6 hours immediately after exercise than it was when water was administered to the horses.	Water	184-189	INS	Equus caballus	74-81
26315345-4	2015	Additionally, aquaporin 1 (AQP1) not only functions as a water channel molecule but also promotes cell migration by facilitating water transport in the lamellipodia of migrating cells.	Water	57-62	aquaporin 1	Rattus norvegicus	27-31
26315345-4	2015	Additionally, aquaporin 1 (AQP1) not only functions as a water channel molecule but also promotes cell migration by facilitating water transport in the lamellipodia of migrating cells.	Water	129-134	aquaporin 1	Rattus norvegicus	14-25
26315345-4	2015	Additionally, aquaporin 1 (AQP1) not only functions as a water channel molecule but also promotes cell migration by facilitating water transport in the lamellipodia of migrating cells.	Water	129-134	aquaporin 1	Rattus norvegicus	27-31
26330489-1	2015	The pharmacological action of peroxisome proliferator-activated receptor (PPAR)gamma in promoting sodium and water retention is well documented as highlighted by the major side-effect of body weight gain and edema associated with thiazolidinedione use.	Water	109-114	peroxisome proliferator activated receptor gamma	Mus musculus	74-78
22326343-1	2012	Since its discovery the therapeutic use of the pancreatic hormone amylin has been limited due to its poor water solubility and propensity for amyloid aggregation.	Water	106-111	islet amyloid polypeptide	Homo sapiens	66-72
22820007-6	2012	The reproducibility of the DNP results is tested on the water soluble maltose binding protein MalE of the ABC maltose importer, where we determine a net standard deviation of 9% in the primary DNP data in the concentration range between 10 and 100 muM.	Water	56-61	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	106-109
22647790-4	2012	C.SJL-Msq1(SJL) mice had disruption of the blood-brain barrier and increased brain water content after MAV-1 infection, but these effects occurred later and were not as severe, respectively, as those noted in infected SJL mice.	Water	83-88	MAV-1 susceptibility QTL 1	Mus musculus	6-10
26995869-7	2015	These results highlight the ability of TaqMan PCR assays using dried saliva on water-soluble paper in genotyping of ADH1B and ALDH2 genes.	Water	79-84	aldehyde dehydrogenase 2 family member	Homo sapiens	126-131
22634839-6	2012	Boiling-water extract of S. baicalensis (SB-WE) could significantly inhibit PGE2 production and COX-2 expression in lipo-polysaccharide-induced RAW 264.7 cells, indicating obvious anti-inflammatory abilities.	Water	8-13	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	96-101
22612103-0	2012	Relaxation and jump dynamics of water at the mica interface.	Water	32-37	MHC class I polypeptide-related sequence A	Homo sapiens	45-49
22285741-2	2012	In this paper, we exploit syndecan-4, a heparan sulfate proteoglycan obtained from cell cultures, in lipid Langmuir monolayers at the air-water interface.	Water	138-143	syndecan 4	Homo sapiens	26-36
22285741-4	2012	Polarization-modulation infrared reflection-absorption spectroscopy (PM-IRRAS) employed in a constant surface pressure regime showed that the main chemical groups for syndecan-4 were present at the air-water interface.	Water	202-207	syndecan 4	Homo sapiens	167-177
22847497-2	2012	The goal of this study was to analyze islet cell composition in diabetic islets for the process of transforming water-soluble IAPP in beta-cells to water-insoluble amyloid deposits by Immunocytochemical staining using different dilutions of anti-IAPP antibody.	Water	112-117	islet amyloid polypeptide	Homo sapiens	126-130
22847497-2	2012	The goal of this study was to analyze islet cell composition in diabetic islets for the process of transforming water-soluble IAPP in beta-cells to water-insoluble amyloid deposits by Immunocytochemical staining using different dilutions of anti-IAPP antibody.	Water	112-117	islet amyloid polypeptide	Homo sapiens	246-250
22847497-2	2012	The goal of this study was to analyze islet cell composition in diabetic islets for the process of transforming water-soluble IAPP in beta-cells to water-insoluble amyloid deposits by Immunocytochemical staining using different dilutions of anti-IAPP antibody.	Water	148-153	islet amyloid polypeptide	Homo sapiens	126-130
22847497-11	2012	In diabetic islets, water-soluble IAPP disappeared in beta-cell granules, which transformed to water-insoluble amyloid deposits.	Water	20-25	islet amyloid polypeptide	Homo sapiens	34-38
22847497-11	2012	In diabetic islets, water-soluble IAPP disappeared in beta-cell granules, which transformed to water-insoluble amyloid deposits.	Water	95-100	islet amyloid polypeptide	Homo sapiens	34-38
22104030-12	2012	Furthermore, VO2, RER, HR, VE, RPE-Br, RPE-Legs, SF, and SBP while walking in water were significantly higher with a water current than without (P &lt; .05).	Water	117-122	selenium binding protein 1	Homo sapiens	57-60
22588904-1	2012	OBJECTIVE: To investigate the role of N-Methyl-D-aspartic acid (NMDA)-type glutamate receptors in the central nucleus of the amygdale (CeA) in food and water intake.	Water	152-157	carcinoembryonic antigen gene family 4	Rattus norvegicus	135-138
22588904-4	2012	RESULTS: Intra-CeA injection of 8.50, 17.00, or 34.00 nmol NMDA did not alter food intake but significantly increased water intake 0-1 h after the injection (F(3,32)=3.191, P=0.037) independent of food intake.	Water	118-123	carcinoembryonic antigen gene family 4	Rattus norvegicus	15-18
22588904-5	2012	Without affecting the food intake, injection of 6.34, 12.70, or 25.40 nmol D-AP-5 into the CeA significantly decreased water intake 0-1 h after the injection (F(3,28)=3.118, P=0.042) independent of food intake.	Water	119-124	carcinoembryonic antigen gene family 4	Rattus norvegicus	91-94
22588904-6	2012	CONCLUSION: NMDA receptors in the CeA may participate in the control of water intake rather than food intake.	Water	72-77	carcinoembryonic antigen gene family 4	Rattus norvegicus	34-37
23004766-12	2012	This is in stark contrast to the other water models (including the polarizable SWM4-NDP model).	Water	39-44	norrin cystine knot growth factor NDP	Homo sapiens	84-87
22392605-4	2012	Both 2 and 3 display water-induced phase transformations with chromotropism, which has been confirmed by TGA and XRPD analysis.	Water	21-26	T-box transcription factor 1	Homo sapiens	105-108
22197795-2	2012	Recent studies have confirmed the anti-ischemic properties of a water-soluble beta-D-fructan (MDG-1) from O. japonicus.	Water	64-69	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	94-99
22285686-2	2012	In the silkworm, Bombyx mori, the movement of water through the epithelia within the cryptonephric rectal complex is likely facilitated by the two aquaporins, AQP-Bom1 and AQP-Bom3.	Water	46-51	aquaporin	Bombyx mori	159-162
22285686-2	2012	In the silkworm, Bombyx mori, the movement of water through the epithelia within the cryptonephric rectal complex is likely facilitated by the two aquaporins, AQP-Bom1 and AQP-Bom3.	Water	46-51	aquaporin	Bombyx mori	172-175
22016195-3	2012	METHODS: Male Long Evans rats trained to discriminate alcohol (1 g/kg, IG) vs. water were exposed to CORT (300 mug/ml) in the home cage drinking water for 7 days.	Water	145-150	cortistatin	Rattus norvegicus	101-105
22568329-4	2012	When the hb-SMCs were given the 200 cm H2O hydrostatic pressure for 0 hour, 2 hours, 6 hours, 12 hours, and 24 hours, the mRNA expressions of TRPV1, TRPV2, and TRPV4 were detected by RT-PCR technique.	Water	39-42	transient receptor potential cation channel subfamily V member 1	Homo sapiens	142-147
22568329-4	2012	When the hb-SMCs were given the 200 cm H2O hydrostatic pressure for 0 hour, 2 hours, 6 hours, 12 hours, and 24 hours, the mRNA expressions of TRPV1, TRPV2, and TRPV4 were detected by RT-PCR technique.	Water	39-42	transient receptor potential cation channel subfamily V member 4	Homo sapiens	160-165
22568329-7	2012	The TRPV1, TRPV2, and TRPV4 genes expressed in hb-SMCs under 200 cm H2O hydrostatic pressure at 0 hour, 2 hours, 6 hours, 12 hours, and 24 hours, but the expressions had no obvious changes with time.	Water	68-71	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
22568329-7	2012	The TRPV1, TRPV2, and TRPV4 genes expressed in hb-SMCs under 200 cm H2O hydrostatic pressure at 0 hour, 2 hours, 6 hours, 12 hours, and 24 hours, but the expressions had no obvious changes with time.	Water	68-71	transient receptor potential cation channel subfamily V member 4	Homo sapiens	22-27
22568329-10	2012	As possible genes in stretch-activated cation channel, the TRPV1, TRPV2, and TRPV4 express in hb-SMCs under 200 cm H2O hydrostatic pressure.	Water	115-118	transient receptor potential cation channel subfamily V member 1	Homo sapiens	59-64
22568329-10	2012	As possible genes in stretch-activated cation channel, the TRPV1, TRPV2, and TRPV4 express in hb-SMCs under 200 cm H2O hydrostatic pressure.	Water	115-118	transient receptor potential cation channel subfamily V member 2	Homo sapiens	66-71
22568329-10	2012	As possible genes in stretch-activated cation channel, the TRPV1, TRPV2, and TRPV4 express in hb-SMCs under 200 cm H2O hydrostatic pressure.	Water	115-118	transient receptor potential cation channel subfamily V member 4	Homo sapiens	77-82
21827828-1	2012	The mineralocorticoid receptor (MR) is a steroid receptor that physiologically regulates water and electrolyte homeostasis but that can also induce pathophysiological effects in the renocardiovascular system.	Water	89-94	nuclear receptor subfamily 3 group C member 2	Homo sapiens	4-30
21827828-1	2012	The mineralocorticoid receptor (MR) is a steroid receptor that physiologically regulates water and electrolyte homeostasis but that can also induce pathophysiological effects in the renocardiovascular system.	Water	89-94	nuclear receptor subfamily 3 group C member 2	Homo sapiens	32-34
21945603-1	2012	Aldosterone controls blood pressure by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor which regulates critical genes controlling salt and water homeostasis in the kidney.	Water	179-184	nuclear receptor subfamily 3 group C member 2	Homo sapiens	54-80
21945603-1	2012	Aldosterone controls blood pressure by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor which regulates critical genes controlling salt and water homeostasis in the kidney.	Water	179-184	nuclear receptor subfamily 3 group C member 2	Homo sapiens	82-84
22366086-4	2012	Genes such as Slc2a5, Cdkn1c, Cabp2, Ranbp3, Vwce and Gcgr were induced by force-feeding with fructose compared with glucose or distilled water.	Water	138-143	cyclin-dependent kinase inhibitor 1C	Rattus norvegicus	22-28
22443769-0	2012	A detailed test study of barrier heights for the HO2 + H2O + O3 reaction with various forms of multireference perturbation theory.	Water	55-58	heme oxygenase 2	Homo sapiens	49-52
22315190-1	2012	The influence of water: crystallization of (R/S)-alpha,beta-CHF-dATP with the preorganized pol beta-DNA complex shows that (S)-alpha,beta-CHF-dATP is preferentially bound to the active site with the C=F fluorine proximal to a structural water bound to Asp276.	Water	17-22	DNA polymerase beta	Homo sapiens	91-99
22801804-1	2012	We present a molecular dynamics simulation study in which we determined the melting point of ice I(h) for the polarizable SWM4-NDP water model (Lamoureux et al., Chem.	Water	131-136	norrin cystine knot growth factor NDP	Homo sapiens	127-130
22801804-4	2012	The simulations yield the melting temperature of SWM4-NDP ice as low as T(m) = 185 +- 10 K, despite the quadrupole moment of a SWM4-NDP water molecule being close to the experimental gas phase value.	Water	136-141	norrin cystine knot growth factor NDP	Homo sapiens	54-57
22879717-10	2012	CONCLUSION: Spa spring water treatment suppressed the inflammatory cytokines production and also modulated the differentiation of CD4(+) T cells into Th1, Th2, and Th17 cells, but not the T(regs) cells.	Water	23-28	surfactant protein A1	Homo sapiens	12-15
22607208-5	2012	This property makes GapC1 sensitive to oxidation by H(2)O(2), which appears to inhibit enzyme activity by converting the thiolate of Cys(149) (-S-) into irreversible oxidized forms (-SO(2)(-) and -SO(3)(-)) via a labile sulfenate intermediate (-SO(-)).	Water	52-57	glyceraldehyde-3-phosphate dehydrogenase C subunit 1	Arabidopsis thaliana	20-25
22763878-4	2012	NADPH-d histochemistry and nNOS immunohistochemistry showed that high concentrations of silicon in drinking water were able to minimize the impairment of the function of nitrergic neurons induced by aluminium administration.	Water	108-113	nitric oxide synthase 1, neuronal	Mus musculus	27-31
22834419-2	2012	Splice variants from the AKAP7 gene (AKAP15/18) are vital components of neuronal and cardiac phosphatase complexes, ion channels, cardiac Ca2+ handling and renal water transport.	Water	162-167	A-kinase anchoring protein 7	Rattus norvegicus	25-30
22834419-2	2012	Splice variants from the AKAP7 gene (AKAP15/18) are vital components of neuronal and cardiac phosphatase complexes, ion channels, cardiac Ca2+ handling and renal water transport.	Water	162-167	A-kinase anchoring protein 7	Rattus norvegicus	37-43
22827927-7	2012	In the heart, 20 ppm of silver nanoparticles in drinking water increased the expression of VEGFA (P &lt; 0.05), at the same time decreasing FGF2 expression both on the transcriptional and translational levels.	Water	57-62	vascular endothelial growth factor A	Gallus gallus	91-96
22676410-4	2012	Water containing EDB was incubated in sealed vials with various combinations of Na(2)S (&lt;0.7 mM) and mackinawite (FeS) (180 mM).	Water	0-5	vesicle associated membrane protein 8	Homo sapiens	17-20
22724888-4	2012	When the fibers were soaked in water before exposure to the oil, the ability of the unmodified kraft fibers to sorb oil was markedly reduced, whereas the wet CTMP fibers were generally more effective than the wet kraft fibers.	Water	31-36	thioesterase superfamily member 4	Homo sapiens	158-162
22222437-6	2012	There were significant correlations between change in body water from baseline to 5150 m with both BNP and NT-proBNP (rho 0.77, P=0.001, rho 0.745, P=0.002 respectively).	Water	59-64	natriuretic peptide B	Homo sapiens	99-102
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Water	39-44	mitogen activated protein kinase 14	Rattus norvegicus	263-266
22261144-12	2012	CONCLUSIONS: The AV-shunt technique allows less invasive, quantitative and reproducible measurement of rCBF in [15O]H2O PET studies in rats than direct blood sampling and radioassay.	Water	116-119	CCAAT/enhancer binding protein zeta	Rattus norvegicus	103-107
25610572-4	2012	Tap water was available to the animals twice daily.	Water	4-9	tracheal antimicrobial peptide	Bos taurus	0-3
22616914-1	2012	Self-assembly of rationally designed asymmetric amphiphilic monomers in water produced nanotube hydrogels in the presence of chemically denatured proteins (green fluorescent protein, carbonic anhydrase, and citrate synthase) at room temperature, which were able to encapsulate the proteins in the one-dimensional channel of the nanotube consisting of a monolayer membrane.	Water	72-77	citrate synthase	Homo sapiens	207-223
22526670-4	2012	Potassium nitrite (0.05 M and 0.6 M) was reacted with 6-MAM (5-10,000 ng/mL) in both water and blank urine with pH adjusted to range from 3 to 8.	Water	85-90	sarcoglycan gamma	Homo sapiens	56-59
22492090-3	2012	Therefore, we sought to determine whether OPN is upregulated in response to ischemia and hypothesized that hydrogen peroxide (H(2)O(2)) is a critical component of the signaling mechanism by which OPN expression is upregulated in response to ischemia in vivo.	Water	126-131	secreted phosphoprotein 1	Mus musculus	196-199
22242910-9	2012	KEY RESULTS: Seven days after metformin administration in drinking water, significantly higher blood lactate, lower pH and HCO(3) (-) levels were observed in Mate1(-/-) mice, but not in Mate1(+/-) mice.	Water	67-72	solute carrier family 47, member 1	Mus musculus	158-163
22541298-1	2012	Inspired by beta-CD, a macrocyclic oligomers of D-(+)-glucopyranose and a renewable material, which could be obtained from starch, that can promote a lot of organic reactions in water, a green solvent, several amino alcohol-modified beta-CDs CD-1 to CD-7 were synthesized in the yields of 36-61%.	Water	178-183	CD1c molecule	Homo sapiens	242-246
22425592-12	2012	AQP9, a channel highly permeable to water and urea, was observed in epithelia of amnion, allantois and yolk sac.	Water	36-41	aquaporin 9	Canis lupus familiaris	0-4
22237802-6	2012	Interestingly, however, water intake and diuresis were significantly higher at baseline in ACBP(-/-) mice compared with that of (+/+) mice.	Water	24-29	diazepam binding inhibitor	Mus musculus	91-95
22237802-7	2012	Subsequent to 20-h water deprivation, ACBP(-/-) mice exhibited increased diuresis, reduced urine osmolality, elevated hematocrit, and higher relative weight loss compared with (+/+) mice.	Water	19-24	diazepam binding inhibitor	Mus musculus	38-42
22315190-1	2012	The influence of water: crystallization of (R/S)-alpha,beta-CHF-dATP with the preorganized pol beta-DNA complex shows that (S)-alpha,beta-CHF-dATP is preferentially bound to the active site with the C=F fluorine proximal to a structural water bound to Asp276.	Water	237-242	DNA polymerase beta	Homo sapiens	91-99
22130631-1	2012	BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO).	Water	206-211	superoxide dismutase 2	Homo sapiens	26-56
22130631-1	2012	BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO).	Water	206-211	superoxide dismutase 2	Homo sapiens	58-63
22115123-8	2012	Water-mediated interactions were also systematically observed in WW (protein-protein interaction domain containing two conserved tryptophan residues), UEV (ubiquitin-conjugating enzyme E2 variant) and EVH-1 [Ena/VASP (vasodilator-stimulated phosphoprotein) homology 1] structures.	Water	0-5	vasodilator stimulated phosphoprotein	Homo sapiens	212-216
22235909-5	2012	We investigated the expression of AQP water channnels (AQP1-9) in the murine larynx and examined the neural regulating mechanisms of these subtypes.	Water	38-43	aquaporin 1	Mus musculus	55-61
26407209-2	2015	CaP1 crystallizes in the monoclinic C2/c space group, with three water molecules occupying a half coordination sphere on one side of the Ca atom, while CaP2 crystallizes in the triclinic P1 space group, with two crystallographic unique Ca atoms, each coordinated by a single water molecule.	Water	65-70	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	0-4
22236806-6	2012	Bovine heart CcO has a proton conducting pathway that includes a hydrogen-bond network and a water-channel which, in tandem, connect the positive side phase with the negative side phase.	Water	93-98	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	13-16
22382682-3	2012	Heterologous expression of ASR1 protein in transgenic yeast cells improved tolerance to abiotic stresses including hydrogen peroxide (H(2)O(2)), high salinity (NaCl), heat shock, menadione, copper sulfate, sulfuric acid, lactic acid, salicylic acid, and also high concentration of ethanol.	Water	134-139	ubiquitin-protein ligase ASR1	Saccharomyces cerevisiae S288C	27-31
22392610-8	2012	Our data suggest that PRX1 has a thioredoxin peroxidase activity reducing both t-BOOH and H(2)O(2), but its cellular function is specified to t-BOOH.	Water	90-95	thioredoxin peroxidase PRX1	Saccharomyces cerevisiae S288C	22-26
26770645-7	2015	In sharp contrast to the C:M phase, water phase was mainly responsible for the production of IL-37.	Water	36-41	interleukin 37	Homo sapiens	93-98
22197056-5	2012	Silica deposition was performed by simply adding tetraethoxysilane to a water/methanol dispersion of PSt/P(St-CPEM)(theta)-g-PDMAEMA.	Water	72-77	sulfotransferase family 1A member 1	Homo sapiens	101-104
22193361-7	2012	Significantly higher oxyHb levels were observed in S1 at 20 s after the onset of water immersion condition and in the PAA at 40 s. Subsequently, oxyHb levels in the SMA and M1 increased significantly 100 s after the onset of water immersion condition.	Water	225-230	survival of motor neuron 1, telomeric	Homo sapiens	165-168
26770645-8	2015	Since ManLAM is the major component of water phase, we found that ManLAM induced IL-37 mRNA and protein expression in a time and dose-dependent manner, while this activity was almost totally abolished by the ERK1/2 (U0126) and p38 (SB203580) inhibitor.	Water	39-44	interleukin 37	Homo sapiens	81-86
22360206-10	2012	The TIP5P-Ewald model demonstrates an increased preference for water molecules to act both as tetrahedral hydrogen bond donors and acceptors, whereas the SWM4-NDP model demonstrates an increased preference for water molecules to act as planar hydrogen bond acceptors.	Water	210-215	norrin cystine knot growth factor NDP	Homo sapiens	159-162
26331790-9	2015	In this paper, we solve both problems by conjugating the hydrophobic GSK3beta inhibitor to a hydrophilic aspartic acid octapeptide using a hydrolyzable bond, thereby generating a bone fracture-targeted water-soluble form of the drug.	Water	202-207	glycogen synthase kinase 3 beta	Homo sapiens	69-77
22509599-4	2012	The Dioxin concentrations in outflow water of bamboo, straw, reed, and bagasse pulping processes (chlorination alkaline extraction hypochlorite, CEH) are 41.8 pg x L(-1), 72.7 pg x L(-1), 7.46 pg x L(-1), and 19.7 pg x L(-1) respectively, which are all around the national waste water discharge standard (30 pg x L(-1)).	Water	37-42	epoxide hydrolase 2	Homo sapiens	145-148
22204983-9	2012	Correlations between chemical, physical and microbiological water quality parameters and Campylobacter spp.	Water	60-65	histocompatibility minor 13	Homo sapiens	103-106
26491508-8	2015	RESULTS: Facial face hydration, elasticity, and transepidermal water loss values significantly improved at T 1 and T 2 (P &lt; .01).	Water	63-68	interleukin 1 receptor like 1	Homo sapiens	107-118
22543127-3	2012	After intake of sucrose solution or distilled water, activated neurons in the CeA were labeled and identified with MOR/Fos-double labeling immunohistochemistry.	Water	46-51	carcinoembryonic antigen gene family 4	Rattus norvegicus	78-81
26185928-0	2015	Hydrolysis of sweet blue lupin hull using subcritical water technology.	Water	54-59	5'-nucleotidase, cytosolic IIIA	Homo sapiens	25-30
22222967-9	2012	Furthermore, straight-chain secondary alcohols increased intracellular Ca(2+) concentrations in HEK293 cells expressing hTRPA1, and both primary and secondary alcohols showed hTRPA1 activation activities that correlated highly with their octanol/water partition coefficients.	Water	246-251	transient receptor potential cation channel subfamily A member 1	Homo sapiens	175-181
22409910-2	2012	Salvianolic acid B (SA-B), a water-soluble active component of Danshen, was found to have anti-myocardial ischemia (anti-MI) effect.	Water	29-34	SH3-domain binding protein 5	Rattus norvegicus	20-24
22158645-7	2012	In addition, AT(2)R stimulation significantly increased sodium and water excretion to a similar extent in males and females (P(Group)=0.05 and 0.005).	Water	67-72	angiotensin II receptor, type 2	Rattus norvegicus	13-19
21995763-2	2012	Classical examples of symbiotic microbes are mycorrhizal fungi that aid in the uptake of water and minerals, and Rhizobium bacteria that fix atmospheric nitrogen for the plant.	Water	89-94	activation induced cytidine deaminase	Homo sapiens	68-71
26185928-1	2015	Hydrolysis of sweet blue lupin hulls was conducted in this study using subcritical water technology.	Water	83-88	5'-nucleotidase, cytosolic IIIA	Homo sapiens	25-30
26222744-4	2015	administration in mice as water-soluble silibinin-hydroxypropyl-beta-cyclodextrin (SLB-HP-beta-CD) lyophilized product.	Water	26-31	beta-carotene oxygenase 1	Mus musculus	90-97
22210899-6	2012	Experiments performed in hydroponics showed that, when water potential was diminished by adding polyethylene glycol, akt1 adult plants lost less water than wild-type (WT) plants.	Water	55-60	K+ transporter 1	Arabidopsis thaliana	117-121
22210899-7	2012	Under long-term water stress in soil, adult akt1 plants displayed lower transpiration and less water consumption than WT plants.	Water	16-21	K+ transporter 1	Arabidopsis thaliana	44-48
22001077-7	2012	In contrast, application of an Ang II type 2 receptor blocker, PD123319, abrogated the prolonged inhibitory effect of Ang II on drinking behavior and partially suppressed the initial increases in water intake.	Water	196-201	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	31-34
22334566-6	2012	Applying an in situ formed iron-based water reduction catalyst derived from [HNEt(3)](+) [HFe(3)(CO)(11)](-) and tris[3,5-tris-(trifluoromethyl)-phenyl]phosphine as the ligand, [Ir(2-phenylbenz-oxazole)(2)-(bpy)]PF(6) proved to be the most efficient complex giving a quantum yield of 16% at 440 nm light irradiation.	Water	38-43	sperm associated antigen 17	Homo sapiens	212-217
22238345-1	2012	Cytochrome c oxidase (COX), the last enzyme of the respiratory chain of aerobic organisms, catalyzes the reduction of molecular oxygen to water.	Water	138-143	cytochrome c oxidase subunit 8A	Homo sapiens	22-25
26260792-9	2015	Mutation of Asp-663 impaired kinase activity to a much greater extent than ATPase, indicating a specific role in peptide substrate binding, whereas mutation of Gln-768 doubled ATPase activity, suggesting that it may act to exclude water from the active site.	Water	231-236	dynein axonemal heavy chain 8	Homo sapiens	176-182
21959772-4	2012	Mice that express a constitutively active Signal Transducer and Activator of Transcription 6 (STAT6VT) have increased Th2 cells and a predisposition to allergic inflammation were used in these studies, they demonstrate that topical treatment with the irritant sodium lauryl sulfate (SLS) caused increased transepidermal water loss and epidermal thickening in STAT6VT mice over similarly treated wild-type mice.	Water	320-325	signal transducer and activator of transcription 6	Mus musculus	42-92
22362238-5	2012	Drinking SPA treatment was effected with sulphurous mineral water from Terme of Telese SpA (Benevento - Italy) and the pharmacological treatment provided the use of hypoglycemic drugs normally used in diabetic disease.	Water	60-65	surfactant protein A1	Homo sapiens	9-12
26372224-4	2015	We analyze data from stored water, rainfall, and water inflow and outflow in the main reservoir serving the metropolitan area of Sao Paulo, Brazil, by means of indicators of critical regime shifts, and find a strong signal of a transition.	Water	49-54	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	129-132
22362238-9	2012	CONCLUSIONS: The data from this preliminary investigation suggest that the drinking SPA therapy with sulphurous mineral water, especially in combination with antidiabetic drug treatment, may be useful in type 2 diabetes mellitus for the improvement redox state of the organism.	Water	120-125	surfactant protein A1	Homo sapiens	84-87
22412692-1	2012	The title compound, C(11)H(7)NO(4) H(2)O, contains a 3-carb-oxy-quinolin-1-ium-2-carboxyl-ate (qda) zwitterion and one water mol-ecule.	Water	35-40	syntaxin 8	Homo sapiens	55-59
29449928-4	2015	High resolution crystal structures were obtained for four BPTI variants in complex with bovine beta-trypsin, revealing changes in the stoichiometry and dynamics of water molecules in the S1 subsite.	Water	164-169	serine protease 1	Bos taurus	95-107
22303032-8	2012	The relatively high frequency of the low-activity CYP2D6 and COMT genotypes in the population warrants further attention, since consumption of free water following ingestion of MDMA in these individuals may trigger dilutational hyponatraemia and increased risk of syndrome of inappropriate antidiuretic hormone secretion.	Water	148-153	catechol-O-methyltransferase	Homo sapiens	61-65
22497151-1	2012	A novel lanthanide 2-hydroxynicotinic acid coordination polymer 1 {[LaL(HL) (H2O)3]1/3 (SO4)2/3 (H3O)2 H2O} (H2 L = 2-hydroxynicotinic acid) has been synthesized under hydrothermal condition and characterized by crystal X-ray diffraction, IR, UV, TGA, two-dimensional infrared (2D IR) correlation spectroscopy with magnetic and thermal perturbation.	Water	103-106	T-box transcription factor 1	Homo sapiens	247-250
26178576-6	2015	PBEF also inhibited the expression of aquaporin 1 (AQP1), which caused a dysfunction and imbalance in water transport.	Water	102-107	nicotinamide phosphoribosyltransferase	Homo sapiens	0-4
22923993-0	2012	Sustained-release G-CSF microspheres using a novel solid-in-oil-in-oil-in-water emulsion method.	Water	74-79	colony stimulating factor 3 (granulocyte)	Mus musculus	18-23
22923993-3	2012	In this study, in order to improve the neutrophilic granulocyte levels in the blood after radiotherapy and chemotherapy, we developed a sustained-release granulocyte colony-stimulating factor (G-CSF) microsphere formulation using a novel solid-in-oil-in-oil-in-water (S/O/O/W) emulsification method.	Water	261-266	colony stimulating factor 3 (granulocyte)	Mus musculus	154-191
22923993-3	2012	In this study, in order to improve the neutrophilic granulocyte levels in the blood after radiotherapy and chemotherapy, we developed a sustained-release granulocyte colony-stimulating factor (G-CSF) microsphere formulation using a novel solid-in-oil-in-oil-in-water (S/O/O/W) emulsification method.	Water	261-266	colony stimulating factor 3 (granulocyte)	Mus musculus	193-198
25225606-5	2012	The 1-adamantylacetamide and para-phenylcarbonyl group were identified to be an optimal primary pharmacophore and secondary pharmacophore motif, respectively, generating sub-nanomolar sEH inhibitors with favorable water solubility.	Water	214-219	epoxide hydrolase 2	Homo sapiens	184-187
26178576-9	2015	Taken together, these results demonstrate that the increase in intracellular PBEF expression promoted the apoptosis of HPMECs and the expression of inflammatory factors and thus enhanced the inflammatory response and inhibited the expression of AQP1, which resulted in abnormal water transport, diminishing the regulatory effects of AQP1 on water transport.	Water	278-283	nicotinamide phosphoribosyltransferase	Homo sapiens	77-81
26178576-9	2015	Taken together, these results demonstrate that the increase in intracellular PBEF expression promoted the apoptosis of HPMECs and the expression of inflammatory factors and thus enhanced the inflammatory response and inhibited the expression of AQP1, which resulted in abnormal water transport, diminishing the regulatory effects of AQP1 on water transport.	Water	341-346	nicotinamide phosphoribosyltransferase	Homo sapiens	77-81
22973103-1	2012	The aim of this study was to develop a temperature-induced polyethylene glycol (PEG) water phase/polysaccharide water-phase emulsion approach for preparing interferon alpha-2b (IFNalpha-2b)-loaded polysaccharide nanoparticles.	Water	85-90	interferon alpha 2	Homo sapiens	156-175
22260483-0	2012	Water-gated charge doping of graphene induced by mica substrates.	Water	0-5	MHC class I polypeptide-related sequence A	Homo sapiens	49-53
26187140-6	2015	[3]PF6 shows a metal-to-ligand charge-transfer absorption band that is red shifted (lambdamax=492 nm in water) compared to its methionine analogue [Ru(tpy)(bpy)(kappaS-HAmet)](Cl)2 ([5](Cl)2, lambdamax=452 nm; HAmet=N-acetyl-methionine).	Water	104-109	sperm associated antigen 17	Homo sapiens	3-6
22260483-1	2012	We report on the existence of water-gated charge doping of graphene deposited on atomically flat mica substrates.	Water	30-35	MHC class I polypeptide-related sequence A	Homo sapiens	84-88
22260483-2	2012	Molecular films of water in units of ~0.4 nm thick bilayers were found to be present in regions of the interface of graphene/mica heterostacks prepared by micromechanical exfoliation of kish graphite.	Water	19-24	MHC class I polypeptide-related sequence A	Homo sapiens	125-129
22973103-1	2012	The aim of this study was to develop a temperature-induced polyethylene glycol (PEG) water phase/polysaccharide water-phase emulsion approach for preparing interferon alpha-2b (IFNalpha-2b)-loaded polysaccharide nanoparticles.	Water	112-117	interferon alpha 2	Homo sapiens	156-175
22182333-8	2012	The amount of strongly bound water present in the hydrogels were estimated from TGA and DSC analysis and the highest value was found for alginate-agarose hydrogels as about 15%.	Water	29-34	T-box transcription factor 1	Homo sapiens	80-83
22142485-0	2012	Water avoidance stress induces frequency through cyclooxygenase-2 expression: a bladder rat model.	Water	0-5	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	49-65
26187140-8	2015	[3]PF6 showed slow photosubstitution of the thiolate ligand by water under blue light irradiation, together with faster photooxidation of the thiolate ligand compared to dark conditions.	Water	63-68	sperm associated antigen 17	Homo sapiens	3-6
28338255-5	2015	The ionization in ASAP experiments is effected by Penning ionization or by the transfer of protons originating from protonated clusters of water.	Water	139-144	microtubule associated protein 9	Homo sapiens	18-22
22142485-3	2012	We investigated the voiding pattern and cyclooxygenase-2 expression in a rat bladder model of water avoidance stress.	Water	94-99	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	40-56
22125096-12	2012	A specific antagonist of the vasopressin V1A- and V2-receptor, conivaptan, promotes water excretion while sparing electrolytes through a process known as aquaresis.	Water	84-89	arginine vasopressin receptor 1A	Homo sapiens	29-61
26014508-0	2015	Osmotic water permeability diversification in primary trophoblast cultures from aquaporin 1-deficient pregnant mice.	Water	8-13	aquaporin 1	Mus musculus	80-91
22403603-1	2012	The kidney maintains water homeostasis by modulating aquaporin 2 (AQP2) on the plasma membrane of collecting duct principal cells in response to vasopressin (VP).	Water	21-26	aquaporin 2	Sus scrofa	53-64
22403603-1	2012	The kidney maintains water homeostasis by modulating aquaporin 2 (AQP2) on the plasma membrane of collecting duct principal cells in response to vasopressin (VP).	Water	21-26	aquaporin 2	Sus scrofa	66-70
22142485-10	2012	Immunohistochemistry and western blotting showed significantly higher cyclooxygenase-2 protein levels in water avoidance stress bladders.	Water	105-110	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	70-86
22142485-12	2012	All water avoidance stress-induced changes were reduced by cyclooxygenase-2 inhibitor pretreatment.	Water	4-9	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	59-75
22142485-14	2012	Further study of cyclooxygenase-2 in the water avoidance stress bladder might provide novel therapeutic modalities for interstitial cystitis.	Water	41-46	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	17-33
26014508-8	2015	The osmotic water permeability of AQP1(-/-) trophoblast cells was significantly lower than that in AQP1(+/+) trophoblast cells, in response to both hypotonic and hypertonic challenges.	Water	12-17	aquaporin 1	Mus musculus	34-38
21889554-3	2012	Herein we report an investigation of the photophysical and photobiological properties of a water soluble bioconjugate of the cationic Tat peptide with a hydrophobic tetraphenylporphyrin derivative.	Water	91-96	tyrosine aminotransferase	Homo sapiens	134-137
22327441-9	2012	CONCLUSION: Students drinking an inadequate amount of water and having a family history had a high prevalence of UTI.	Water	54-59	alpha-1-microglobulin/bikunin precursor	Homo sapiens	113-116
26014508-9	2015	CONCLUSION: The results suggest an important role of AQP1-mediated plasma membrane water permeability in maternal-fetal fluid balance and also provide a potential direction for the identification of therapeutic targets for the treatment of abnormalities in amniotic fluid volume.	Water	83-88	aquaporin 1	Mus musculus	53-57
26286528-10	2015	CONCLUSIONS: The new DUSP5 inhibitors we identify in this study typically have sulfonates 7 A apart, likely positioning them where the two phosphates of the substrate peptide (pThr-Glu-pTyr) bind, with one inhibitor also positioning a phenolic hydroxyl where the water nucleophile may reside.	Water	263-268	dual specificity phosphatase 5	Homo sapiens	21-26
22050080-3	2011	Three well-defined surfaces [H-Si(111), graphite, and functionalized mica] were investigated, and water was found to adsorb as nanodroplets (~10-100 nm in size) on all three surfaces under ambient conditions.	Water	98-103	MHC class I polypeptide-related sequence A	Homo sapiens	69-73
21880835-1	2011	It was hypothesized that cyclooxygenase-2 (COX-2) activity promotes urine concentrating ability through stimulation of vasopressin (AVP) release after water deprivation (WD).	Water	151-156	prostaglandin-endoperoxide synthase 2	Mus musculus	25-41
22289137-8	2012	The 52-week-old UT-B-null mice exhibited polyuria after water deprivation, although urine osmolality was increased.	Water	56-61	solute carrier family 14 (urea transporter), member 1	Mus musculus	16-20
26284549-2	2015	However, EAU induced by native IRBP protein or its widely used epitope amino acid residues 1 to 20 of human IRBP (hIRBP1-20) is inconsistent, often showing low scores and incidence.	Water	9-12	retinol binding protein 3	Homo sapiens	31-35
20889219-1	2012	BACKGROUND: STK39 interacts with OXSR1 and phosphorylates the sodium-chloride co-transporter (SLC12A3), which plays a critical role in regulating the salt/water balance and blood pressure.	Water	155-160	oxidative stress responsive kinase 1	Homo sapiens	33-38
20889219-1	2012	BACKGROUND: STK39 interacts with OXSR1 and phosphorylates the sodium-chloride co-transporter (SLC12A3), which plays a critical role in regulating the salt/water balance and blood pressure.	Water	155-160	solute carrier family 12 member 3	Homo sapiens	94-101
21880835-1	2011	It was hypothesized that cyclooxygenase-2 (COX-2) activity promotes urine concentrating ability through stimulation of vasopressin (AVP) release after water deprivation (WD).	Water	151-156	prostaglandin-endoperoxide synthase 2	Mus musculus	43-48
21880835-3	2011	In male COX-2(-/-), basal urine output and water intake were elevated while urine osmolality was decreased compared with WT.	Water	43-48	prostaglandin-endoperoxide synthase 2	Mus musculus	8-13
21880835-4	2011	Water deprivation resulted in lower urine osmolality, higher plasma osmolality in COX-2(-/-) mice irrespective of gender.	Water	0-5	prostaglandin-endoperoxide synthase 2	Mus musculus	82-87
21975647-4	2011	In addition to these more frequently studied effects of GLP-1R stimulation, previous reports indicate that GLP-1R agonists suppress water intake.	Water	132-137	glucagon like peptide 1 receptor	Homo sapiens	107-113
21975647-5	2011	The present experiments were designed to provide greater temporal resolution and site specificity for the effect of GLP-1 and the long-acting GLP-1R agonists, exendin-4 and liraglutide, on unstimulated water intake when food was and was not available.	Water	202-207	glucagon like peptide 1 receptor	Homo sapiens	142-148
22181675-0	2012	Water adsorption on clay minerals as a function of relative humidity: application of BET and Freundlich adsorption models.	Water	0-5	delta/notch like EGF repeat containing	Homo sapiens	85-88
22181675-2	2012	The water content as a function of RH was modeled using the Brunauer, Emmett, and Teller (BET) and Freundlich adsorption isotherm models to provide complementary multilayer adsorption analysis of water uptake on the clays.	Water	4-9	delta/notch like EGF repeat containing	Homo sapiens	90-93
21975647-6	2011	All three GLP-1R ligands suppressed water intake after peripheral intraperitoneal administration, both in the presence of and the absence of food; however, the magnitude and time frame of water intake suppression varied by drug.	Water	36-41	glucagon like peptide 1 receptor	Homo sapiens	10-16
22181675-4	2012	From the BET fit to the experimental data, the water content on each of the three clays at monolayer (ML) water coverage was determined and found to agree with previously reported gravimetric data.	Water	47-52	delta/notch like EGF repeat containing	Homo sapiens	9-12
21975647-6	2011	All three GLP-1R ligands suppressed water intake after peripheral intraperitoneal administration, both in the presence of and the absence of food; however, the magnitude and time frame of water intake suppression varied by drug.	Water	188-193	glucagon like peptide 1 receptor	Homo sapiens	10-16
21975647-8	2011	Additionally, intracerebroventricular administration of GLP-1R agonists suppressed water intake when food was absent, but the suppression of intake showed modest differences depending on whether the drug was administered to the lateral or fourth ventricle.	Water	83-88	glucagon like peptide 1 receptor	Homo sapiens	56-62
21975647-9	2011	To the best of our knowledge, this is the first demonstration of GLP-1 receptor agonists affecting unstimulated, overnight intake in the absence of food, the first test for antidipsogenic effects of hindbrain application of GLP-1 receptor agonists, and the first test of a central effect (forebrain or hindbrain) of liraglutide on water intake.	Water	331-336	glucagon like peptide 1 receptor	Homo sapiens	65-79
26284549-2	2015	However, EAU induced by native IRBP protein or its widely used epitope amino acid residues 1 to 20 of human IRBP (hIRBP1-20) is inconsistent, often showing low scores and incidence.	Water	9-12	retinol binding protein 3	Homo sapiens	108-112
25154599-1	2015	PURPOSE: To demonstrate the phase evolutions of direct visualization of short transverse relaxation time component (ViSTa) matches with those of myelin water.	Water	152-157	V-set immunoregulatory receptor	Homo sapiens	116-121
21889156-5	2011	The decreased average pore diameter and increased BET surface area of the mat, caused by spider-net like structure, can make it as a potential candidate for air/water filtration.	Water	161-166	delta/notch like EGF repeat containing	Homo sapiens	50-53
22191804-2	2012	Electrons transferred from cytochrome c to CcO"s catalytic site reduce molecular oxygen and produce a water molecule.	Water	102-107	LOC104968582	Bos taurus	27-39
25154599-8	2015	Additionally, the myelin water phase map generated using diffusion tensor imaging (DTI) information revealed a good match with the ViSTa phase image.	Water	25-30	V-set immunoregulatory receptor	Homo sapiens	131-136
22191804-2	2012	Electrons transferred from cytochrome c to CcO"s catalytic site reduce molecular oxygen and produce a water molecule.	Water	102-107	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	43-46
25154599-9	2015	CONCLUSION: The results of this study support the origin of ViSTa signal as myelin water.	Water	83-88	V-set immunoregulatory receptor	Homo sapiens	60-65
25244429-1	2015	A pH-sensitive and double functional nanoprobe was designed and synthesized in a water-soluble system using thioglycolic acid (TGA) and mercapto-acetohydrazide (TGH) as the stabilizers.	Water	81-86	carboxylesterase 1	Homo sapiens	161-164
22111949-0	2012	The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics.	Water	144-149	galectin 3	Homo sapiens	33-43
21832987-7	2011	MAO-A(Neo) mice showed a unique set of behavioral abnormalities, encompassing reduced open-field locomotion, perseverative responses, such as marble burying and water mist-induced grooming, and a lack of anxiety-like behaviors in the elevated plus-maze and light-dark box paradigms.	Water	161-166	monoamine oxidase A	Mus musculus	0-5
26076213-1	2015	Highly stable FAU-type zeolite membrane for the separation of isopropanol (IPA)-water mixture by pervaporation is described.	Water	80-85	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	14-17
22500444-1	2011	A novel method was developed for trace analysis of aliphatic aldehydes and ketones in water-based adhesive based on 2,4-dinitrophenylhydrazine (DNPH) direct derivatization-1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM] PF6) preconcentration coupled with high performance liquid chromatography (HPLC).	Water	86-91	sperm associated antigen 17	Homo sapiens	228-231
22070314-0	2011	Quasistatic computer simulations of shear behavior of water nanoconfined between mica surfaces.	Water	54-59	MHC class I polypeptide-related sequence A	Homo sapiens	81-85
22070314-4	2011	An important information is obtained by splitting the stress tensor components into contributions arising from the interaction of the opposing mica sheets between themselves and their interaction with water.	Water	201-206	MHC class I polypeptide-related sequence A	Homo sapiens	143-147
22070314-8	2011	The water-mica contribution is slightly less in magnitude but opposite in sign.	Water	4-9	MHC class I polypeptide-related sequence A	Homo sapiens	10-14
22113212-0	2012	Water transport by glucose transporter type 3 expressed in Xenopus oocytes.	Water	0-5	solute carrier family 2 member 3 L homeolog	Xenopus laevis	19-45
22113212-1	2012	The hypothesis that the facilitative glucose transporter type 3 (GLUT3) in the brain also exhibits water channel properties similar to that of GLUT1 was tested in Xenopus oocytes expressing human GLUT3 or GLUT1.	Water	99-104	solute carrier family 2 member 3 L homeolog	Xenopus laevis	37-63
22113212-1	2012	The hypothesis that the facilitative glucose transporter type 3 (GLUT3) in the brain also exhibits water channel properties similar to that of GLUT1 was tested in Xenopus oocytes expressing human GLUT3 or GLUT1.	Water	99-104	solute carrier family 2 member 3 L homeolog	Xenopus laevis	65-70
22113212-3	2012	The osmotic water permeability (Pf) for GLUT3 or GLUT1 increased significantly compared with that for oocytes-injected water.	Water	12-17	solute carrier family 2 member 3 L homeolog	Xenopus laevis	40-45
26076213-2	2015	FAU membrane showed high water permselectivity and permeance.	Water	25-30	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	0-3
22113212-4	2012	The osmotic water transport by GLUT3 was completely inhibited by treatment with a selective GLUT inhibitor, cytochalasin B.	Water	12-17	solute carrier family 2 member 3 L homeolog	Xenopus laevis	31-36
22113212-6	2012	Thus, GLUT3 in the brain also exhibits water channel properties.	Water	39-44	solute carrier family 2 member 3 L homeolog	Xenopus laevis	6-11
26076213-3	2015	Comparison of FAU membrane with a conventional LTA-type zeolite membrane revealed superior stability of FAU zeolite membrane in a mixture containing a large water content.	Water	157-162	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	104-107
21617200-10	2011	These findings suggest that TLR4 takes part in airway mucosal defense systems as a unique exogenous potentiator of electrolyte-water secretion from submucosal gland acinar cells, and that NO/cGMP/cGK signaling is involved in this rapid TLR4 signaling pathway.	Water	127-132	toll like receptor 4	Sus scrofa	28-32
25187115-5	2015	To achieve similar accuracy by the numerical solution of the MODFLOW Surface-Water Routing (SWR1) Process requires many small time steps.	Water	77-82	Snf2 related CREBBP activator protein	Homo sapiens	92-96
21703367-6	2011	However, it is shown that the ketoenamine form dominates in the absence of ring protonation when PLP is solvated by polar groups such as water.	Water	137-142	pyridoxal phosphatase	Homo sapiens	97-100
23555502-9	2012	High endothelial venules in the node strongly express Aquaporin-1, suggesting their involvement in the net absorption of water from lymph coming through afferent lymphatics.	Water	121-126	aquaporin 1	Rattus norvegicus	54-65
26136669-11	2015	We conclude that exposure to the water maze evokes ERK MAPK activation, distinct epigenetic changes and IEG induction predominantly in sparse dentate gyrus neurons.	Water	33-38	mitogen activated protein kinase 3	Rattus norvegicus	55-59
22154292-1	2012	For the quantitative assessment of the glutathione reductase (GR) activity with a (19)F NMR spectroscopy, we developed the heavy metal-free probes based on silica nanoparticles modified with water-soluble perfluorinated dendrimers via the disulfide linkers.	Water	191-196	glutathione-disulfide reductase	Homo sapiens	39-60
22154292-1	2012	For the quantitative assessment of the glutathione reductase (GR) activity with a (19)F NMR spectroscopy, we developed the heavy metal-free probes based on silica nanoparticles modified with water-soluble perfluorinated dendrimers via the disulfide linkers.	Water	191-196	glutathione-disulfide reductase	Homo sapiens	62-64
21939279-4	2011	A peak observed in the zero-shear viscosity (eta(0)) versus L-02 concentration curve shifted toward higher L-02 concentrations and the value of maximum viscosity (eta(0 max)) increased with the increasing ChEO(20) mixing fraction with water.	Water	235-240	endothelin receptor type A	Homo sapiens	45-48
21939279-4	2011	A peak observed in the zero-shear viscosity (eta(0)) versus L-02 concentration curve shifted toward higher L-02 concentrations and the value of maximum viscosity (eta(0 max)) increased with the increasing ChEO(20) mixing fraction with water.	Water	235-240	endothelin receptor type A	Homo sapiens	163-166
22139335-1	2011	Aquaporin 1 (AQP1) is a water channel protein expressed in endothelial and epithelial cells of many tissues, including the vasculature, where it serves to increase water permeability of the cell membrane.	Water	24-29	aquaporin-1	Sus scrofa	0-11
22139335-1	2011	Aquaporin 1 (AQP1) is a water channel protein expressed in endothelial and epithelial cells of many tissues, including the vasculature, where it serves to increase water permeability of the cell membrane.	Water	24-29	aquaporin-1	Sus scrofa	13-17
25962668-2	2015	Here we show that azF residues situated on the transmembrane surfaces of detergent-solubilized receptors exhibit up to 1000-fold rate enhancement relative to azF residues on water-exposed surfaces.	Water	174-179	AZF1	Homo sapiens	18-21
21973321-0	2011	The water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid.	Water	4-9	male germ cell-associated kinase	Mus musculus	100-103
21973321-4	2011	In this study, we investigated the water-soluble, polysaccharide components of Reishi (designated as MAK) in murine colitis induced by trinitrobenzene sulphonic acid (TNBS).	Water	35-40	male germ cell-associated kinase	Mus musculus	101-104
22523994-1	2012	We synthesized organic solvent-soluble and water-soluble PbS quantum dots (QDs) with different sizes.	Water	43-48	cholinergic receptor muscarinic 3	Homo sapiens	57-60
22523994-3	2012	The water-soluble PbS QDs were used to prepare bilayer structures of QDs on quartz based on alternating adsorption of polyelectrolyte.	Water	4-9	cholinergic receptor muscarinic 3	Homo sapiens	18-21
25962668-2	2015	Here we show that azF residues situated on the transmembrane surfaces of detergent-solubilized receptors exhibit up to 1000-fold rate enhancement relative to azF residues on water-exposed surfaces.	Water	174-179	AZF1	Homo sapiens	158-161
25532697-7	2015	The difference in the IC50 values for sulindac between AR (0.36 muM) and AKR1B10 (2.7 muM) might be explained by the different positioning and stacking interaction given by Phe122/Phe123, and by the presence of two buried and ordered water molecules in AKR1B10 but not in AR.	Water	234-239	aldo-keto reductase family 1 member B10	Homo sapiens	73-80
23029160-2	2012	Low-Ca(2+) fresh water stimulated Ca(2+) influx and expressions of epithelial calcium channel (ecac), vitamin D-25-hydroxylase (cyp2r1), vitamin D receptor a (vdra), and vdrb in zebrafish.	Water	17-22	transient receptor potential cation channel, subfamily V, member 6	Danio rerio	67-93
23029160-2	2012	Low-Ca(2+) fresh water stimulated Ca(2+) influx and expressions of epithelial calcium channel (ecac), vitamin D-25-hydroxylase (cyp2r1), vitamin D receptor a (vdra), and vdrb in zebrafish.	Water	17-22	transient receptor potential cation channel, subfamily V, member 6	Danio rerio	95-99
21948545-10	2011	In addition, the administration of OX40-activating antibody prolonged and exacerbated the disease course of EAU.	Water	108-111	tumor necrosis factor receptor superfamily, member 4	Mus musculus	35-39
25944897-2	2015	A substrate of IRAP is vasopressin, which controls water homeostasis.	Water	51-56	leucyl/cystinyl aminopeptidase	Mus musculus	15-19
21896864-8	2011	RESULTS: Expression of Notch1, 2, 4, and Dll4 in the eye were upregulated by EAU induction.	Water	77-80	delta like canonical Notch ligand 4	Mus musculus	41-45
22509266-9	2012	OR2eta expression in the olfactory system is restricted to the medium cavity, which participates in the detection of water-soluble odorants, suggesting that OR2etas function as receptors for water-soluble odorants.	Water	117-122	or2	Xenopus tropicalis	0-3
22509266-9	2012	OR2eta expression in the olfactory system is restricted to the medium cavity, which participates in the detection of water-soluble odorants, suggesting that OR2etas function as receptors for water-soluble odorants.	Water	191-196	or2	Xenopus tropicalis	0-3
21918198-0	2011	TLR agonists downregulate H2-O in CD8alpha- dendritic cells.	Water	26-30	CD8 antigen, alpha chain	Mus musculus	34-42
25959102-3	2015	We demonstrate that the reaction of U(VI) with formohydroxamate does not result in reduction, but rather in formation of the putative cis-aquo UO2(FHA)2(H2O)2, whose polymeric solid-state structure, UO2(FHA)2, contains an unusually bent UO2(2+) unit and a highly distorted coordination environment around a U(VI) cation in general.	Water	153-156	FHII	Homo sapiens	143-152
21918198-3	2011	In this study, we show that H2-O is markedly downregulated in vivo in mouse CD8alpha(-) DCs in response to a broad array of TLR agonists.	Water	28-32	CD8 antigen, alpha chain	Mus musculus	76-84
21918198-4	2011	In contrast, CD8alpha(+) DCs only modestly downregulated H2-O in response to TLR agonists.	Water	57-61	CD8 antigen, alpha chain	Mus musculus	13-21
23109565-5	2012	From entry point (raw sewage) to effluent level (tertiary treatment effluent water), the experimental results showed that the reduction ratios of human adenoviruses were 1.2 log10 in STP1 and 1.9 log10 in STP2.	Water	77-82	sulfotransferase family 1A member 2	Homo sapiens	205-209
21822534-6	2011	Also, 12-month-old NSE/hPen-2 Tg mice displayed behavioral dysfunction in the water maze test, motor activity and feeding behavior dysfunction in food intake/water intake/motor activity monitoring system.	Water	78-83	enolase 2, gamma neuronal	Mus musculus	19-22
21822534-6	2011	Also, 12-month-old NSE/hPen-2 Tg mice displayed behavioral dysfunction in the water maze test, motor activity and feeding behavior dysfunction in food intake/water intake/motor activity monitoring system.	Water	158-163	enolase 2, gamma neuronal	Mus musculus	19-22
21865171-8	2011	Replenishment of PM cholesterol from intracellular cholesterol stores or by the addition of water-soluble cholesterol restores amylin oligomer clustering at the PM and internalization, which consequently diminishes cell surface coverage and toxicity of amylin oligomers.	Water	92-97	islet amyloid polypeptide	Homo sapiens	127-133
25959102-3	2015	We demonstrate that the reaction of U(VI) with formohydroxamate does not result in reduction, but rather in formation of the putative cis-aquo UO2(FHA)2(H2O)2, whose polymeric solid-state structure, UO2(FHA)2, contains an unusually bent UO2(2+) unit and a highly distorted coordination environment around a U(VI) cation in general.	Water	153-156	FHII	Homo sapiens	199-208
21865171-8	2011	Replenishment of PM cholesterol from intracellular cholesterol stores or by the addition of water-soluble cholesterol restores amylin oligomer clustering at the PM and internalization, which consequently diminishes cell surface coverage and toxicity of amylin oligomers.	Water	92-97	islet amyloid polypeptide	Homo sapiens	253-259
21879047-1	2011	Zn(2)GeO(4)-ethylenediamine (ZGO-EDA) hybrid nanoribbons have been synthesized on a large-scale and directly assembled to membranes, which exhibit an excellent recyclability, high selectivity, and good thermal stability for highly efficient removal of heavy metal ions, i.e., Pb(2+), Cd(2+), Co(2+), and Cu(2+), from contaminated water.	Water	330-335	ectodysplasin A	Homo sapiens	33-36
21940485-2	2011	Proof-of-principle studies performed in rats have shown that treatment with corticosteroids upregulates the expression of AQP1 in the peritoneal capillaries, causing a significant increase in free water transport.	Water	197-202	aquaporin 1	Rattus norvegicus	122-126
25270072-1	2015	Transepithelial water flow across the renal proximal tubule is mediated predominantly by aquaporin-1 (AQP1).	Water	16-21	aquaporin 1	Mus musculus	89-100
21832082-3	2011	The mitochondrial peroxidase peroxiredoxin-3 reduces H(2)O(2) to water using reducing equivalents from NADPH supplied by thioredoxin-2 (Trx2) and, ultimately, thioredoxin reductase-2 (TrxR2).	Water	65-70	thioredoxin reductase 2	Mus musculus	159-182
21832082-3	2011	The mitochondrial peroxidase peroxiredoxin-3 reduces H(2)O(2) to water using reducing equivalents from NADPH supplied by thioredoxin-2 (Trx2) and, ultimately, thioredoxin reductase-2 (TrxR2).	Water	65-70	thioredoxin reductase 2	Mus musculus	184-189
25270072-1	2015	Transepithelial water flow across the renal proximal tubule is mediated predominantly by aquaporin-1 (AQP1).	Water	16-21	aquaporin 1	Mus musculus	102-106
25892399-3	2015	The oral insulin/DCK complex was prepared by making a physical complex of insulin aspart with DCK through ion-pair interaction in water.	Water	130-135	deoxycytidine kinase	Homo sapiens	17-20
21733844-1	2011	Human aquaporin10 (hAQP10) is a transmembrane facilitator of both water and glycerol transport in the small intestine.	Water	66-71	aquaporin 10	Homo sapiens	6-17
21733844-1	2011	Human aquaporin10 (hAQP10) is a transmembrane facilitator of both water and glycerol transport in the small intestine.	Water	66-71	aquaporin 10	Homo sapiens	19-25
21733844-5	2011	All three forms of hAQP10 where found to facilitate the transport of water, glycerol, erythritol, and xylitol, and glycosylation had little effect on functionality.	Water	69-74	aquaporin 10	Homo sapiens	19-25
22147976-8	2011	Due to high water content, mucin has a similar appearance to water on ultrasound (US), computed tomography (CT), and magnetic resonance imaging, except when thick and proteinaceous, and then it tends to be hypoechoic with fine internal echoes or have complex echogenicity on US, hyperdense on CT, and hyperintense on T1- and hypointense on T2-weighted images, compared to water.	Water	12-17	LOC100508689	Homo sapiens	27-32
22147976-8	2011	Due to high water content, mucin has a similar appearance to water on ultrasound (US), computed tomography (CT), and magnetic resonance imaging, except when thick and proteinaceous, and then it tends to be hypoechoic with fine internal echoes or have complex echogenicity on US, hyperdense on CT, and hyperintense on T1- and hypointense on T2-weighted images, compared to water.	Water	61-66	LOC100508689	Homo sapiens	27-32
22147976-8	2011	Due to high water content, mucin has a similar appearance to water on ultrasound (US), computed tomography (CT), and magnetic resonance imaging, except when thick and proteinaceous, and then it tends to be hypoechoic with fine internal echoes or have complex echogenicity on US, hyperdense on CT, and hyperintense on T1- and hypointense on T2-weighted images, compared to water.	Water	61-66	LOC100508689	Homo sapiens	27-32
22214473-2	2011	This study aimed to validate rCBF measurements by perfusion CT with positron-emission tomography [PET] and15O-labelled water [15O-H2O] in healthy subjects.	Water	119-124	CCAAT/enhancer binding protein zeta	Rattus norvegicus	29-33
22214473-2	2011	This study aimed to validate rCBF measurements by perfusion CT with positron-emission tomography [PET] and15O-labelled water [15O-H2O] in healthy subjects.	Water	130-133	CCAAT/enhancer binding protein zeta	Rattus norvegicus	29-33
25892399-3	2015	The oral insulin/DCK complex was prepared by making a physical complex of insulin aspart with DCK through ion-pair interaction in water.	Water	130-135	deoxycytidine kinase	Homo sapiens	94-97
25922513-6	2015	RESULTS: We found that 6 weeks of alcohol consumption (10% in drinking water) worsens ischemic lesions and cancels the beneficial effects of tPA-induced thrombolysis.	Water	71-76	plasminogen activator, tissue	Mus musculus	141-144
21972997-4	2011	A series of water-soluble PR-targeted magnetic resonance imaging (MRI) probes were synthesized using Cu(I)-catalyzed click chemistry and evaluated in vitro and in vivo.	Water	12-17	progesterone receptor	Homo sapiens	26-28
21989727-4	2011	METHODS: Wild-type and MC5r-/- mice were immunized to induce EAU.	Water	61-64	melanocortin 5 receptor	Mus musculus	23-27
21989727-7	2011	RESULTS: IRBPp-specific CD25+CD4+ T cells from spleens of EAU-recovered wild-type mice express a Treg cell phenotype of FoxP3 and TGF-beta compared with the effector T-cell phenotype of IFN-gamma and IL-17 production in EAU-recovered MC5r-/- mice.	Water	58-61	transforming growth factor, beta 1	Mus musculus	130-138
21989727-7	2011	RESULTS: IRBPp-specific CD25+CD4+ T cells from spleens of EAU-recovered wild-type mice express a Treg cell phenotype of FoxP3 and TGF-beta compared with the effector T-cell phenotype of IFN-gamma and IL-17 production in EAU-recovered MC5r-/- mice.	Water	58-61	melanocortin 5 receptor	Mus musculus	234-238
21684550-4	2011	Single force curves for a mica-silica system in a 10(-4)M aqueous NaCl solution at pH ~ 5.1 show oscillations with a period of about 0.25 nm, roughly the diameter of a water molecule, a consequence of a layer-by-layer dehydration of the surfaces when pushed together.	Water	168-173	MHC class I polypeptide-related sequence A	Homo sapiens	26-30
21844271-10	2011	Delayed access to feed and water increased the CD25(+) cell number in the cecal tonsil at 2, 6, and 8 d posthatch.	Water	27-32	interleukin 2 receptor subunit alpha	Homo sapiens	47-51
25853430-0	2015	A water-stable lanthanide-functionalized MOF as a highly selective and sensitive fluorescent probe for Cd(2.).	Water	2-7	lysine acetyltransferase 8	Homo sapiens	41-44
21703663-3	2011	The main metabolite is 2,6-dichlorobenzamide (BAM) which is water soluble and causes ground water contamination.	Water	60-65	structural maintenance of chromosomes 3	Homo sapiens	46-49
21703663-3	2011	The main metabolite is 2,6-dichlorobenzamide (BAM) which is water soluble and causes ground water contamination.	Water	92-97	structural maintenance of chromosomes 3	Homo sapiens	46-49
21703663-8	2011	The most unusual and extreme concentration of BAM ever found in ground water is 560 mug/L.	Water	71-76	structural maintenance of chromosomes 3	Homo sapiens	46-49
22013111-9	2011	Meanwhile, the severity of AP, determined by histological examination, tissue water content, myeloperoxidase activity, and plasma amylase activity, was markedly better in mice that received exogenous NEP treatment.	Water	78-83	membrane metallo endopeptidase	Mus musculus	200-203
25563835-3	2015	In 236 water samples tested, 54 (22.9%) contained Salmonella spp.	Water	7-12	histocompatibility minor 13	Homo sapiens	61-64
21819963-3	2011	In contrast, an N-terminally truncated Tat protein (aa 35-86) that lacks the structurally defined proline- and cysteine-rich region as well as the highly conserved tryptophan residue at position 11 generates pores in artificial POPC-membranes, through which a water-soluble dye up to a size of 10kDa can pass.	Water	260-265	tyrosine aminotransferase	Homo sapiens	39-42
21770411-2	2011	Treatment of Mn(III)SO-MOF with H(2)O(2) effects the removal of the Mn(3+) ions from the salen struts, which can then be remetalated with a variety of metal precursors to form isostructural MSO-MOF materials.	Water	32-37	lysine acetyltransferase 8	Homo sapiens	23-26
21770411-2	2011	Treatment of Mn(III)SO-MOF with H(2)O(2) effects the removal of the Mn(3+) ions from the salen struts, which can then be remetalated with a variety of metal precursors to form isostructural MSO-MOF materials.	Water	32-37	lysine acetyltransferase 8	Homo sapiens	194-197
21739967-11	2011	The EFER calculations illustrate the considerable importance of Arg183 and an O(lg)-proximal water molecule to pol beta fidelity.	Water	93-98	DNA polymerase beta	Homo sapiens	111-119
25596185-5	2015	hETHE1 contains an alphabetabetaalpha MBL-fold, which supports metal-binding by the side chains of an aspartate and two histidine residues; three water molecules complete octahedral coordination of the iron.	Water	146-151	ETHE1 persulfide dioxygenase	Homo sapiens	0-6
21718028-2	2011	From BET monolayer value to a(w) = 0.61 and 0.75 for green and roasted coffee, respectively, the solid matrix hydration occurred and water induced hardening.	Water	133-138	delta/notch like EGF repeat containing	Homo sapiens	5-8
21821260-7	2011	In the solutions containing fluorocarbon surfactants, the gamma(C) values were different taking into account the contact angle in the range of FSN100 and FSO100 concentration corresponding to their unsaturated monolayer at water-air interface or to that saturated.	Water	223-228	interleukin 2 receptor subunit gamma	Homo sapiens	58-66
25488608-0	2015	Pathogenic and commensal Escherichia coli from irrigation water show potential in transmission of extended spectrum and AmpC beta-lactamases determinants to isolates from lettuce.	Water	58-63	beta-lactamase	Escherichia coli	120-124
22328868-13	2011	Therefore, we also apply HSMD to FKBP12-L8 described by the GSBP/SSBP model of Roux"s group (implemented in the software CHARMM) where only part of the protein and water around the active site are considered and long-range electrostatic effects are taken into account.	Water	164-169	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	33-39
21372807-2	2011	The glycosylphosphatidylinositol (GPI)-anchored protein, CD73, is released from adipocytes into microvesicles in response to the lipogenic stimuli, palmitate, the antidiabetic sulfonylurea drug glimepiride, phosphoinositolglycans (PIG), and H(2)O(2).	Water	241-246	5' nucleotidase, ecto	Rattus norvegicus	57-61
25728056-3	2015	Compound 1 is a 0D discrete molecule, in which Zn(II) is in a trigonal bipyramidal coordination geometry, whereas the guest Hpta(-) as counteranion is hydrogen-bonded with the [Zn(bpz)2(H2O)3].	Water	186-189	hepatocyte growth factor	Homo sapiens	124-128
21469159-0	2011	Role of bridging water molecules in GSK3beta-inhibitor complexes: insights from QM/MM, MD, and molecular docking studies.	Water	17-22	glycogen synthase kinase 3 beta	Homo sapiens	36-44
21469159-2	2011	In this study, we employ the two-layer ONIOM-based quantum mechanics/molecular mechanics (QM/MM) calculations, molecular dynamics (MD) simulations, and molecular docking studies to investigate the effect of bridging water molecules at the GSK3beta-inhibitors interfaces.	Water	216-221	glycogen synthase kinase 3 beta	Homo sapiens	239-247
21469159-3	2011	The results obtained from the ONIOM geometry optimization and AIM analysis corroborated the presence of bridging water molecules that form hydrogen bonds with protein side chain of Thr138 and/or backbone of Gln185, and mediate interactions with inhibitors in the 10 selected GSK3beta-inhibitor complexes.	Water	113-118	glycogen synthase kinase 3 beta	Homo sapiens	275-283
21469159-4	2011	Subsequently, MD simulations carried out on a representative system of 1R0E demonstrated that the bridging water molecule is stable at the GSK3beta-inhibitor interface and appears to contribute to the stability of the protein-inhibitor interactions.	Water	107-112	glycogen synthase kinase 3 beta	Homo sapiens	139-147
21469159-5	2011	Furthermore, molecular docking studies of GSK3beta-inhibitor complexes indicated that the inhibitors can increase binding affinities and the better docked conformation of inhibitors can be obtained by inclusion of the bridging water molecules, especially for the flexible inhibitors, in docking experiments into individual protein conformations.	Water	227-232	glycogen synthase kinase 3 beta	Homo sapiens	42-50
21469159-6	2011	Our results elucidate the importance of bridging water molecules at the GSK3beta-inhibitor interfaces and suggest that they might prove useful in rational drug design.	Water	49-54	glycogen synthase kinase 3 beta	Homo sapiens	72-80
21708120-0	2011	Electron transfer mediated by membrane-bound d-fructose dehydrogenase adsorbed at an oil/water interface.	Water	89-94	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	45-69
21708120-1	2011	The catalytic activity of a membrane-bound enzyme, d-fructose dehydrogenase (FDH), at the polarized oil/water (O/W) interface was studied.	Water	104-109	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	51-75
21708120-1	2011	The catalytic activity of a membrane-bound enzyme, d-fructose dehydrogenase (FDH), at the polarized oil/water (O/W) interface was studied.	Water	104-109	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	77-80
21854740-2	2011	Aquaporin-1 (AQP1) is a water channel, overexpressed in cirrhosis, that promotes angiogenesis by enhancing endothelial invasion.	Water	24-29	aquaporin 1	Mus musculus	0-11
24893788-5	2015	However, ecac mRNA levels and the density of ecac-expressing ionocytes were increased in fish acclimated to acidic water, and maximal Ca(2+) uptake capacity (J MAX) was significantly increased when measured in control water (pH ~7.4).	Water	115-120	transient receptor potential cation channel, subfamily V, member 6	Danio rerio	9-13
21854740-2	2011	Aquaporin-1 (AQP1) is a water channel, overexpressed in cirrhosis, that promotes angiogenesis by enhancing endothelial invasion.	Water	24-29	aquaporin 1	Mus musculus	13-17
21625719-1	2011	The introduction of hydrophobic groups (e.g. methyl) at the most adjacent sites of each and every coordinating nitrogen atom of the bipyridine pillar linker in a carboxylate-based bridging MOF could shield the metal ions from attack by water molecules, and thus enhance the water resistance of the MOF structure significantly.	Water	236-241	lysine acetyltransferase 8	Homo sapiens	189-192
21625719-1	2011	The introduction of hydrophobic groups (e.g. methyl) at the most adjacent sites of each and every coordinating nitrogen atom of the bipyridine pillar linker in a carboxylate-based bridging MOF could shield the metal ions from attack by water molecules, and thus enhance the water resistance of the MOF structure significantly.	Water	236-241	lysine acetyltransferase 8	Homo sapiens	298-301
21625719-1	2011	The introduction of hydrophobic groups (e.g. methyl) at the most adjacent sites of each and every coordinating nitrogen atom of the bipyridine pillar linker in a carboxylate-based bridging MOF could shield the metal ions from attack by water molecules, and thus enhance the water resistance of the MOF structure significantly.	Water	274-279	lysine acetyltransferase 8	Homo sapiens	189-192
25834422-2	2015	MRI signal intensity is related to the relaxation times (T 1, spin-lattice relaxation and T 2, spin-spin relaxation) of in vivo water protons.	Water	128-133	interleukin 1 receptor like 1	Homo sapiens	57-60
21602033-2	2011	The targeted disruption of MC5R in mice resulted in reduced sebaceous lipid production and a severe defect in water repulsion.	Water	110-115	melanocortin 5 receptor	Mus musculus	27-31
25284167-1	2015	A novel adsorbent of expanded graphite (EG) loaded with lanthanum oxide (EG-LaO) was prepared for phosphate removal from water and characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectroscopy.	Water	121-126	interleukin 4 induced 1	Homo sapiens	76-79
21719661-3	2011	However, their identification of histidine-84 of EF-Tu as deprotonating the catalytic water molecule is problematic in relation to their atomic structure; the terminal phosphate of GTP is more likely to be the proper proton acceptor.	Water	86-91	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	49-54
21721649-2	2011	Most importantly, we find that even the water dipoles inside the CNT are maintained along the field direction, a large amount of water molecules can still transport against the field direction for short CNTs, leading to a low unidirectional transport efficiency (eta).	Water	129-134	endothelin receptor type A	Homo sapiens	263-266
25641073-5	2015	Antisecretory factor (AF) regulates ion and water transport through the intestinal cell membrane.	Water	44-49	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Rattus norvegicus	0-20
21711498-6	2011	TGA/DTA results confirmed the weight loss and the exothermic reaction due to desorption of chemisorbed water.	Water	103-108	T-box transcription factor 1	Homo sapiens	0-3
25645975-2	2015	The 131-residue polypeptide Ste2p(G31-R161), TM1-TM3, was investigated by solution NMR in trifluoroethanol/water.	Water	107-112	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	28-33
21495665-9	2011	By separating the total interaction (or potential of mean force, PMF) between plates into the direct and the water-mediated interactions, we observe that the latter changes from repulsive to attractive, clearly emphasizing the important role of water as a medium.	Water	245-250	proline rich protein BstNI subfamily 1	Homo sapiens	65-68
25600809-8	2015	We have found that CdCl2 intake in the drinking water led to the inhibition of 35% and 30% of MMP2 and MMP9 (p &lt; 0.05) at the ventral prostate and testis, respectively, in Cd(2+) treated animals when compared to controls.	Water	48-53	matrix metallopeptidase 2	Rattus norvegicus	94-98
21596572-6	2011	However, in the case of preparing the inclusion complexes of CDs with ACA by a solid phase "high-speed vibration milling" technique, the average inclusion rates of the obtained water-soluble complexes were calculated as 88+-13% (beta-CD), 70+-1% (Mebeta-CD), and 63+-2% (HPbeta-CD), respectively, by (1)H NMR analysis.	Water	177-182	beta-carotene oxygenase 1	Mus musculus	229-236
25236224-5	2015	Based on the results of SDS-PAGE, DSC and SEM, it was revealed that the movement of low molecular weight hydrophilic protein was depressed by the cross-linking network structure induced by TGase and SPI during film drying, indicating that adding SPI is essential to improve the thermal stability and water resistance properties of TGase-induced gelatin films.	Water	300-305	transglutaminase 1	Homo sapiens	189-194
21532393-5	2011	Centrally injected NKB inhibited peripherally injected angiotensin II-induced water intake.	Water	78-83	tachykinin precursor 3	Rattus norvegicus	19-22
25681923-1	2015	A (1)H and (19)F nuclear magnetic resonance study of [Mg(H2O)6](BF4)2 has confirmed the existence of two phase transitions at Tc1   257 K and Tc2   142 K, detected earlier by the DSC method.	Water	57-60	transcobalamin 2	Homo sapiens	142-145
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	22-27	MHC class I polypeptide-related sequence A	Homo sapiens	48-52
25671581-6	2015	Real-time RT-PCR analysis along with zymography revealed that the wound area of the hot spring water group exhibited a higher expression of matrix metalloproteinases-2 and -9 compared to the two other control groups.	Water	95-100	matrix metallopeptidase 2	Rattus norvegicus	140-174
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	22-27	MHC class I polypeptide-related sequence A	Homo sapiens	297-301
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	22-27	MHC class I polypeptide-related sequence A	Homo sapiens	297-301
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	42-47	MHC class I polypeptide-related sequence A	Homo sapiens	48-52
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	42-47	MHC class I polypeptide-related sequence A	Homo sapiens	297-301
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	42-47	MHC class I polypeptide-related sequence A	Homo sapiens	297-301
25664248-7	2015	Ang 1-7 reduces vasoconstriction, water retention, salt intake, cell proliferation, and reactive oxygen stress, and also has a renoprotective effect.	Water	34-39	angiopoietin 1	Homo sapiens	0-5
21266296-3	2011	Above the water percolation transition (at 320 K), the reduced hIAPP moiety presents a considerably diminished helical content remaining unstructured, while the natural cystine moiety reaches a rather compact state, presenting a radius of gyration that is almost 10% smaller and characterized by intrapeptide H-bonds that form many beta-bridges in the C-terminal region.	Water	10-15	islet amyloid polypeptide	Homo sapiens	63-68
25391898-11	2015	These results demonstrate that stimulation of ENaC by AVP plays a critical role in water homeostasis by facilitating urinary concentration, which can compensate for hypernatremia or exacerbate hyponatremia.	Water	83-88	arginine vasopressin	Mus musculus	54-57
21442446-1	2011	Noncovalent DIDS binding to Band 3 (AE1) protein in human erythrocyte membranes, modified by non-penetrating, water soluble 1-ethyl-3-(4-azonia-4,4-dimethylpentyl)-carbodiimide iodide (EAC), was studied at 0 C in the presence of 165 mM KCl.	Water	110-115	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	36-39
25592019-3	2015	METHODS: Closed tibial transverse fractures were generated in 6-wk-old male C3 H/HeJ mice given either tap water or MBP-supplemented water for 3, 7, 14, 28, and 56 d after fracture generation.	Water	133-138	myelin basic protein	Mus musculus	116-119
21371868-5	2011	Experimental results support that remaining water in the sample contributed to increase HAp crystallinity.	Water	44-49	reticulon 3	Homo sapiens	88-91
21502813-1	2011	Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins that allow the movement of water and other small solutes, especially glycerol, through cell membranes.	Water	110-115	aquaporin 10	Homo sapiens	40-45
25550365-9	2015	Exogenous Norrin treatment significantly alleviated neurobehavioral dysfunction, reduced brain water content and Evans blue extravasation, promoted beta-catenin nuclear translocation, and increased Occludin, VE-Cadherin, and ZO-1 expressions.	Water	95-100	norrin cystine knot growth factor NDP	Rattus norvegicus	10-16
21437341-0	2011	Effects of varying water adsorption on a Cu3(BTC)2 metal-organic framework (MOF) as studied by 1H and 13C solid-state NMR spectroscopy.	Water	19-24	lysine acetyltransferase 8	Homo sapiens	76-79
21437341-1	2011	The process of water adsorption on a dehydrated Cu(3)(BTC)(2) (copper (II) benzene 1,3,5-tricarboxylate) metal-organic framework (MOF) was studied with (1)H and (13)C solid-state NMR.	Water	15-20	lysine acetyltransferase 8	Homo sapiens	105-134
25451277-0	2015	Localization of aquaporin 1 water channel in the Schmidt-Lanterman incisures and the paranodal regions of the rat sciatic nerve.	Water	28-33	aquaporin 1	Rattus norvegicus	16-27
21437341-3	2011	(1)H and (13)C MAS NMR spectra of dehydrated and water-loaded Cu(3)(BTC)(2) samples gave evidence on the structural changes due to water adsorption within the MOF material as well as information on water dynamics.	Water	49-54	lysine acetyltransferase 8	Homo sapiens	159-162
21437341-3	2011	(1)H and (13)C MAS NMR spectra of dehydrated and water-loaded Cu(3)(BTC)(2) samples gave evidence on the structural changes due to water adsorption within the MOF material as well as information on water dynamics.	Water	131-136	lysine acetyltransferase 8	Homo sapiens	159-162
25451277-1	2015	Aquaporin 1 (AQP1) is a member of a family of small, integral membrane water-transporting proteins, which facilitate water movement across cell membranes in response to osmotic gradients.	Water	71-76	aquaporin 1	Rattus norvegicus	0-11
21445095-10	2011	From these results, we conclude that complex I-derived O(2) (-), produced through reverse electron transport due to enhanced metabolism and a high activity of complex I, was dismutated into H(2)O(2) by MnSOD induced via NF-kappaB activation and that the dismutated mH(2)O(2) stimulated muscle differentiation as a signaling messenger.	Water	190-195	superoxide dismutase 2	Homo sapiens	202-207
25451277-1	2015	Aquaporin 1 (AQP1) is a member of a family of small, integral membrane water-transporting proteins, which facilitate water movement across cell membranes in response to osmotic gradients.	Water	71-76	aquaporin 1	Rattus norvegicus	13-17
25451277-1	2015	Aquaporin 1 (AQP1) is a member of a family of small, integral membrane water-transporting proteins, which facilitate water movement across cell membranes in response to osmotic gradients.	Water	117-122	aquaporin 1	Rattus norvegicus	0-11
25451277-1	2015	Aquaporin 1 (AQP1) is a member of a family of small, integral membrane water-transporting proteins, which facilitate water movement across cell membranes in response to osmotic gradients.	Water	117-122	aquaporin 1	Rattus norvegicus	13-17
25552345-1	2015	We report a novel green chemical approach for the synthesis of blue light-emitting and water-soluble Ag subnanoclusters, using sodium cholate (NaC) as a template at a concentration higher than the critical micelle concentration (CMC) at room temperature.	Water	87-92	melanocyte inducing transcription factor a	Danio rerio	143-146
21273049-8	2011	Using biphasic model, the thermodynamic parameters viz; DeltaG (m), DeltaH (m) and DeltaS (m) for SDS-water and SDS-peptide-water mixed micellar systems, the standard free energy for transfer of SDS from aqueous to peptide additive environments were estimated at various temperatures.	Water	102-107	serine dehydratase	Homo sapiens	98-101
21273049-8	2011	Using biphasic model, the thermodynamic parameters viz; DeltaG (m), DeltaH (m) and DeltaS (m) for SDS-water and SDS-peptide-water mixed micellar systems, the standard free energy for transfer of SDS from aqueous to peptide additive environments were estimated at various temperatures.	Water	124-129	serine dehydratase	Homo sapiens	112-115
21273049-8	2011	Using biphasic model, the thermodynamic parameters viz; DeltaG (m), DeltaH (m) and DeltaS (m) for SDS-water and SDS-peptide-water mixed micellar systems, the standard free energy for transfer of SDS from aqueous to peptide additive environments were estimated at various temperatures.	Water	124-129	serine dehydratase	Homo sapiens	112-115
20845069-6	2011	The synergistic effect of TNF-alpha and H(2)O(2) on the NF-kappaB signaling pathway (transcriptional activity and p65 nuclear translocation) was also observed.	Water	40-45	RELA proto-oncogene, NF-kB subunit	Homo sapiens	114-117
21575091-10	2011	The atabcg22 mutation further increased the water loss of srk2e/ost1 mutants, which were defective in ABA signalling in guard cells.	Water	44-49	ribophorin I	Homo sapiens	64-68
21273049-9	2011	These results suggest that the SDS is more stable in micellized form in the SDS-water-peptide ternary systems compared to the situation in the corresponding SDS-water binary systems.	Water	80-85	serine dehydratase	Homo sapiens	31-34
25531275-5	2015	For instance, for aerogels with a sulfonation of 10%, the diffusivity of a volatile organic compound (1,2-dichloroethane, DCE) from 10 ppm aqueous solution is more than 3 orders of magnitude higher than that for the unsulfonated aerogel and is very close to the DCE diffusivity in water.	Water	281-286	24-dehydrocholesterol reductase	Homo sapiens	122-125
21273049-9	2011	These results suggest that the SDS is more stable in micellized form in the SDS-water-peptide ternary systems compared to the situation in the corresponding SDS-water binary systems.	Water	80-85	serine dehydratase	Homo sapiens	76-79
21273049-9	2011	These results suggest that the SDS is more stable in micellized form in the SDS-water-peptide ternary systems compared to the situation in the corresponding SDS-water binary systems.	Water	80-85	serine dehydratase	Homo sapiens	76-79
21273049-9	2011	These results suggest that the SDS is more stable in micellized form in the SDS-water-peptide ternary systems compared to the situation in the corresponding SDS-water binary systems.	Water	161-166	serine dehydratase	Homo sapiens	31-34
21678957-4	2011	Water contact angles were found to be 66 , 15 , and 0  for SS-BP, SS-PHEMA, and SS-PPGL, respectively.	Water	0-5	single stranded DNA binding protein 1	Homo sapiens	59-64
26633825-4	2015	It was shown that the H19 gene was significantly downmethylated in E2.5, E3.5, and E4.5 embryos from pregnant mice treated with 120 mg/l NaF in drinking water for 48 h. But methylation of both H19 and Peg3 genes was disrupted when the parent male mice were treated with NaF for 35 days.	Water	153-158	H19, imprinted maternally expressed transcript	Mus musculus	22-25
21441404-15	2011	HvPIP2;5, HvPIP2;2, and HvTIP1;1 are prime candidates to mediate water flow in cortical tissue.	Water	65-70	PIP2;5	Hordeum vulgare	0-8
21489960-2	2011	Yolk granules, which contain phosvitin, were precipitated after diluting egg yolk with 9 volumes of distilled water.	Water	110-115	casein kinase 2 beta	Homo sapiens	29-38
21431140-4	2011	These photochemical products most likely form, after hydrogen bonding between C(24)H(12) and H(2)O, through ionization of the PAH and subsequent reactivity with water upon irradiation.	Water	93-98	phenylalanine hydroxylase	Homo sapiens	126-129
21431140-4	2011	These photochemical products most likely form, after hydrogen bonding between C(24)H(12) and H(2)O, through ionization of the PAH and subsequent reactivity with water upon irradiation.	Water	161-166	phenylalanine hydroxylase	Homo sapiens	126-129
21505865-2	2011	Their response to several abiotic stimuli has also been investigated in leaves: HvSs1 is up-regulated by anoxia and HvSs3 by water deprivation while no response is observed to 150 mM NaCl treatment; HvSs1 and HvSs3 are also induced by cold temperatures.	Water	125-130	Sucrose synthase 1	Hordeum vulgare	80-85
25945116-2	2015	On the basis of our previous study regarding a water-soluble extract from the culture medium of Ganoderma lucidum mycelia (designed as MAK), which exerts antioxidative and neuroprotective effects, the present study was conducted to evaluate the preventive effects of MAK on apoptosis and necroptosis (a programmed necrosis) induced by hypoxia/ischemia (H/I) in type 2 diabetic KKAy mice.	Water	47-52	male germ cell-associated kinase	Mus musculus	135-138
21291881-0	2011	Colonic submucosal 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in water-immersion restraint stressed rats.	Water	111-116	5-hydroxytryptamine receptor 3A	Rattus norvegicus	19-35
21291881-10	2011	Taken together, these results suggest that the 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in the water-immersion restraint stressed rats, which may contribute to the acute stress-induced increase in colonic secretion.	Water	143-148	5-hydroxytryptamine receptor 3A	Rattus norvegicus	47-63
25945116-2	2015	On the basis of our previous study regarding a water-soluble extract from the culture medium of Ganoderma lucidum mycelia (designed as MAK), which exerts antioxidative and neuroprotective effects, the present study was conducted to evaluate the preventive effects of MAK on apoptosis and necroptosis (a programmed necrosis) induced by hypoxia/ischemia (H/I) in type 2 diabetic KKAy mice.	Water	47-52	male germ cell-associated kinase	Mus musculus	267-270
21639142-2	2011	In this work, we present a comparative explicit water molecular dynamics (MD) study on the free and inhibitor-bound HLE.	Water	48-53	elastase, neutrophil expressed	Homo sapiens	116-119
26667573-6	2015	Inhibition of vha-20 by RNAi leads to complex deterioration of water and pH gradients at the level of the whole organism including distention of pseudocoelome cavity.	Water	63-68	Vacuolar H ATPase	Caenorhabditis elegans	14-20
21558561-6	2011	These products are absent in 12R-LOX-deficient mice, which crucially display a near total absence of protein-bound omega-hydroxyceramides and of the corneocyte lipid envelope and die shortly after birth from transepidermal water loss.	Water	223-228	arachidonate 12-lipoxygenase, 12R type	Mus musculus	29-36
21477270-4	2011	RESULTS: Water, glycerol, propylene glycol and ethylene glycol permeability of zebrafish Aqp3a, -3b, -7, -9a, -9b, -10a and -10b, and human AQP3, was examined.	Water	9-14	aquaporin 3a	Danio rerio	89-94
21477270-7	2011	Water and ethylene glycol transport through DrAqp3a and -3b were, however, highest at pH 8.5 and completely abolished at pH 6.0.	Water	0-5	aquaporin 3a	Danio rerio	44-59
25053075-4	2015	Moreover, differential scanning calorimetry (DSC), the mechanical properties and the water vapour permeability studies revealed that TGase favoured the strong intramolecular polymerisation of the peptides in gelatin.	Water	85-90	transglutaminase 1	Homo sapiens	133-138
21250745-2	2011	In this paper, we investigate the spreading of aqueous solutions of water-soluble surfactants over entangled, aqueous mucin solutions that mimic the airway surface liquid of the lung.	Water	68-73	LOC100508689	Homo sapiens	118-123
21690334-0	2011	Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88.	Water	28-33	MYD88 innate immune signal transduction adaptor	Homo sapiens	118-123
25277410-10	2015	Induction of colitis and water avoidance stress increased levels of Mir29a and Mir29b and intestinal permeability in wild-type mice; these increased intestinal permeability in colons of far fewer Mir29(-/-) mice.	Water	25-30	microRNA 29a	Mus musculus	68-74
21671676-1	2011	A microbial desalination cell (MDC) is a new approach for desalinating water based on using the electrical current generated by exoelectrogenic bacteria.	Water	71-76	C-C motif chemokine ligand 22	Homo sapiens	31-34
21345671-0	2011	Design and synthesis of novel enhanced water soluble hydroxyethyl analogs of combretastatin A-4.	Water	39-44	carbonic anhydrase 4	Mus musculus	77-95
25751538-0	2015	An overview of a novel, water-soluble undenatured type II collagen (NEXT-II).	Water	24-29	collagen type II alpha 1 chain	Canis lupus familiaris	50-66
21188590-5	2011	The contaminated drinking water was positive for genes characteristic of various E. coli pathotypes: pic, invE, hlyA, ent, escV, eae, aggR, stx(2) , estIa and astA.	Water	26-31	hemolysin transport protein	Escherichia coli	112-116
21412259-6	2011	Our study demonstrated that heme oxygenase-1 (HO-1) was the most induced antioxidant gene in PIG1 cells after treatment with H(2)O(2).	Water	125-130	nuclear FMR1 interacting protein 2	Homo sapiens	93-97
25751538-3	2015	METHODS AND RESULTS: We developed a novel, water-soluble, undenatured type II collagen (NEXT-II) for osteoarthritis.	Water	43-48	collagen type II alpha 1 chain	Canis lupus familiaris	70-86
25751538-11	2015	Key Teaching Points:  A novel, water-soluble, undenatured type II collagen (NEXT-II) was developed for osteoarthritis.	Water	31-36	collagen type II alpha 1 chain	Canis lupus familiaris	58-74
26121019-1	2015	This study evaluates the potential for a novel semidecentralized approach that uses coagulant disinfectant products (CDPs) for humanitarian water treatment, by testing two commercially available products (CDP-W and CDP-T).	Water	140-145	cut like homeobox 1	Homo sapiens	117-120
21553841-4	2011	However, one of the findings of this study is that when SP-A is bound to detergent and lipid micelles that mimic lung surfactant phospholipids, it exists predominantly as smaller oligomers, in sharp contrast to the much larger forms observed when alone in water.	Water	256-261	surfactant protein A1	Homo sapiens	56-60
20559711-1	2011	The influence of ambient water quality on the settlement of barnacles and the green alga Enteromorpha spp.	Water	25-30	histocompatibility minor 13	Homo sapiens	102-105
25707467-1	2015	Cytochrome c oxidase (CcO) is the terminal oxidase of cell respiration which reduces molecular oxygen (O2) to H2O coupled with the proton pump.	Water	110-113	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
21248284-5	2011	Furthermore, suppression of PRDX2 resulted in the augmentation of endogenous H(2)O(2), and the ability to eliminate the exogenous H(2)O(2) was attenuated.	Water	77-82	peroxiredoxin 2	Mus musculus	28-33
21248284-5	2011	Furthermore, suppression of PRDX2 resulted in the augmentation of endogenous H(2)O(2), and the ability to eliminate the exogenous H(2)O(2) was attenuated.	Water	130-135	peroxiredoxin 2	Mus musculus	28-33
21421249-7	2011	In a laboratory-scale system, ammonium oxidation of synthetic reject water passed through the cathode chamber of an MFC, increased from 73.8 +- 8.9 mgN/L under open-circuit conditions to 160.1 +- 4.8 mgN/L when a current of 1.96 +- 0.37 mA (15.1 mA/L total MFC liquid volume) was flowing through the MFC.	Water	69-74	myelin and lymphocyte protein, T cell differentiation protein	Mus musculus	3-4
21421249-7	2011	In a laboratory-scale system, ammonium oxidation of synthetic reject water passed through the cathode chamber of an MFC, increased from 73.8 +- 8.9 mgN/L under open-circuit conditions to 160.1 +- 4.8 mgN/L when a current of 1.96 +- 0.37 mA (15.1 mA/L total MFC liquid volume) was flowing through the MFC.	Water	69-74	myelin and lymphocyte protein, T cell differentiation protein	Mus musculus	152-153
21421249-7	2011	In a laboratory-scale system, ammonium oxidation of synthetic reject water passed through the cathode chamber of an MFC, increased from 73.8 +- 8.9 mgN/L under open-circuit conditions to 160.1 +- 4.8 mgN/L when a current of 1.96 +- 0.37 mA (15.1 mA/L total MFC liquid volume) was flowing through the MFC.	Water	69-74	myelin and lymphocyte protein, T cell differentiation protein	Mus musculus	204-205
21421249-7	2011	In a laboratory-scale system, ammonium oxidation of synthetic reject water passed through the cathode chamber of an MFC, increased from 73.8 +- 8.9 mgN/L under open-circuit conditions to 160.1 +- 4.8 mgN/L when a current of 1.96 +- 0.37 mA (15.1 mA/L total MFC liquid volume) was flowing through the MFC.	Water	69-74	myelin and lymphocyte protein, T cell differentiation protein	Mus musculus	6-7
21421249-7	2011	In a laboratory-scale system, ammonium oxidation of synthetic reject water passed through the cathode chamber of an MFC, increased from 73.8 +- 8.9 mgN/L under open-circuit conditions to 160.1 +- 4.8 mgN/L when a current of 1.96 +- 0.37 mA (15.1 mA/L total MFC liquid volume) was flowing through the MFC.	Water	69-74	myelin and lymphocyte protein, T cell differentiation protein	Mus musculus	246-250
21435100-3	2011	In the present study we investigate the hypothesis that the unique water dispersible oleic acid-Triton X-100-coated Fe3O4 nanoparticles loaded with HCPT disrupt epithelial cell-cell junctions and induce human lung cancer cell apoptosis through the caspase-8 pathway.	Water	67-72	caspase 8	Homo sapiens	248-257
25707467-1	2015	Cytochrome c oxidase (CcO) is the terminal oxidase of cell respiration which reduces molecular oxygen (O2) to H2O coupled with the proton pump.	Water	110-113	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
25707467-6	2015	Each electron transfer step from heme a to the O2reduction site is coupled with the proton pump.X-ray structural and mutational analyses of bovine CcO show three possible proton transfer pathways which can transfer pump protons (H) and chemical (water-forming) protons (K and D).	Water	246-251	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	147-150
21332130-6	2011	In the present work, we show that a representative mucin glycoprotein, bovine submaxillary mucin, has impressive and unprecedented capabilities of binding and solubilizing water-insoluble materials in physiological solution.	Water	172-177	mucin 1, cell surface associated	Bos taurus	51-56
24837420-1	2015	As global fisheries decline, microbial single-cell protein (SCP) produced from brewery process water has been highlighted as a potential source of protein for sustainable animal feed.	Water	95-100	urocortin 3	Homo sapiens	60-63
21332130-6	2011	In the present work, we show that a representative mucin glycoprotein, bovine submaxillary mucin, has impressive and unprecedented capabilities of binding and solubilizing water-insoluble materials in physiological solution.	Water	172-177	mucin 1, cell surface associated	Bos taurus	91-96
21351297-3	2011	A model for this structure was obtained in a previous study of water-ligand dissociation from the hexacoordinate model complex of the X-ray crystal structure of the catalytic domain of phenylalanine hydroxylase in complex with the cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH(4)) (PAH-Fe(II)-BH(4)).	Water	63-68	phenylalanine hydroxylase	Homo sapiens	185-210
21998601-3	2011	This study was undertaken to test the hypothesis that cyclophosphamide may produce water retention via the proximal nephron, where aquaporin-1 (AQP1) and aquaporin-7 (AQP7) water channels participate in water absorption.	Water	83-88	aquaporin 1	Rattus norvegicus	131-142
21998601-9	2011	From these preliminary data, we conclude that the proximal nephron may be involved in cyclophosphamide-induced water retention via AQP1 and AQP7 water channels.	Water	111-116	aquaporin 1	Rattus norvegicus	131-135
25814919-4	2015	The water-soluble fraction of CBG-CS-2 has high anti-inflammatory activity in LPS-induced Raw264.7 macrophages.	Water	4-9	calsyntenin 2	Mus musculus	34-38
21496801-12	2011	Pharmacologic concentrations of GnRH agonist decreased NFAT5 expression, suggesting that water flows out of leiomyoma cells at pharmacologic doses.	Water	89-94	gonadotropin releasing hormone 1	Homo sapiens	32-36
21496801-12	2011	Pharmacologic concentrations of GnRH agonist decreased NFAT5 expression, suggesting that water flows out of leiomyoma cells at pharmacologic doses.	Water	89-94	nuclear factor of activated T cells 5	Homo sapiens	55-60
21252231-0	2011	Expression of water-soluble, ligand-binding concatameric extracellular domains of the human neuronal nicotinic receptor alpha4 and beta2 subunits in the yeast Pichia pastoris: glycosylation is not required for ligand binding.	Water	14-19	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	131-136
21252231-6	2011	We then linked the mutated ECDs with the 24-amino acid peptide (AGS)(8) and observed that the beta2-24-alpha4 ECD concatamer, but not the alpha4-24-beta2 one, exhibited very satisfactory water solubility and ligand binding properties.	Water	187-192	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	94-99
25909724-1	2015	Fat, oil and grease (FOG) recovered by the oil/water separator of a wastewater treatment plant (WWTP) were sampled, characterized, activated and converted into biofuel.	Water	47-52	FAT atypical cadherin 1	Homo sapiens	0-19
20584001-4	2011	To confirm the role of macrophages in EAU, we examined EAU in CCR2 KO mice.	Water	55-58	chemokine (C-C motif) receptor 2	Mus musculus	62-66
21557328-3	2011	TGFalpha-dependent ERK oscillations mediated through the epidermal growth factor receptor (EGFR) are inhibited by low dose X-irradiation (10 cGy) and low concentrations of hydrogen peroxide (0.32-3.26 microM H(2)O(2)) used as a model reactive oxygen species (ROS).	Water	208-213	transforming growth factor alpha	Homo sapiens	0-8
25479565-5	2014	Surface analysis confirmed degradation of the surface of GaN after radiation exposure in water; however, the peptide molecules successfully remained on the surface following exposure to ionizing radiation.	Water	89-94	gigaxonin	Homo sapiens	57-60
21518777-2	2011	The mucilage of the mucilage modified1 (mum1) mutant contains rhamnogalacturonan I that is more highly branched and lacks the ability to be extruded when exposed to water.	Water	165-170	LEUNIG-like protein	Arabidopsis thaliana	40-44
21198587-2	2011	Respiratory turbinates lie anteriorly and aid in heat and water conservation, while more posterior olfactory turbinates function in olfaction.	Water	58-63	activation induced cytidine deaminase	Homo sapiens	42-45
24999995-2	2014	Here, we demonstrate that the same MBP biosensor can be combined with a microfluidic system for detection of maltose in water or beer.	Water	120-125	myelin basic protein	Homo sapiens	35-38
21259319-11	2011	In the presence of 30 muM Hg2+, which inhibits water movement through AQP1 and AQP9, the hypoosmolarity-induced water influxes were reduced.	Water	47-52	aquaporin 1	Rattus norvegicus	70-74
21259319-11	2011	In the presence of 30 muM Hg2+, which inhibits water movement through AQP1 and AQP9, the hypoosmolarity-induced water influxes were reduced.	Water	112-117	aquaporin 1	Rattus norvegicus	70-74
21376373-3	2011	Here we investigated the possible involvement of sGC, NO, plasminogen activator inhibitor (PAI-1) and p38 MAP Kinase in antithrombotic effects of CO released by a novel, water-soluble, CO releasing molecule-3 (CORM-3) using rat.	Water	170-175	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	49-52
21376373-3	2011	Here we investigated the possible involvement of sGC, NO, plasminogen activator inhibitor (PAI-1) and p38 MAP Kinase in antithrombotic effects of CO released by a novel, water-soluble, CO releasing molecule-3 (CORM-3) using rat.	Water	170-175	mitogen activated protein kinase 14	Rattus norvegicus	102-105
25657739-1	2014	Thermomineral water from the Atomic Spa Gornja Trepca has been used for a century in the treatment of neurologic disease.	Water	14-19	surfactant associated protein A1	Mus musculus	36-39
21277918-3	2011	These water-soluble PAAs efficiently condense beta-galactosidase by self-assembly into nanoscaled and positively-charged complexes.	Water	6-11	galactosidase beta 1	Homo sapiens	46-64
21321232-7	2011	In stark contrast to the bulk, this 1D water wire not only exhibits enormous dielectric anomalies at approximately 175 and 277 K, respectively, but also undergoes a spontaneous transition between "1D liquid" and "1D ferroelectric ice" at approximately 277 K. Hitherto unrevealed properties of the 1D water wire will be valuable to the understanding of anomalous properties of water and synthesis of novel ferroelectric materials.	Water	39-44	leiomodin 1	Homo sapiens	196-199
21321232-7	2011	In stark contrast to the bulk, this 1D water wire not only exhibits enormous dielectric anomalies at approximately 175 and 277 K, respectively, but also undergoes a spontaneous transition between "1D liquid" and "1D ferroelectric ice" at approximately 277 K. Hitherto unrevealed properties of the 1D water wire will be valuable to the understanding of anomalous properties of water and synthesis of novel ferroelectric materials.	Water	39-44	leiomodin 1	Homo sapiens	212-215
21321232-7	2011	In stark contrast to the bulk, this 1D water wire not only exhibits enormous dielectric anomalies at approximately 175 and 277 K, respectively, but also undergoes a spontaneous transition between "1D liquid" and "1D ferroelectric ice" at approximately 277 K. Hitherto unrevealed properties of the 1D water wire will be valuable to the understanding of anomalous properties of water and synthesis of novel ferroelectric materials.	Water	300-305	leiomodin 1	Homo sapiens	196-199
21321232-7	2011	In stark contrast to the bulk, this 1D water wire not only exhibits enormous dielectric anomalies at approximately 175 and 277 K, respectively, but also undergoes a spontaneous transition between "1D liquid" and "1D ferroelectric ice" at approximately 277 K. Hitherto unrevealed properties of the 1D water wire will be valuable to the understanding of anomalous properties of water and synthesis of novel ferroelectric materials.	Water	300-305	leiomodin 1	Homo sapiens	212-215
21321232-7	2011	In stark contrast to the bulk, this 1D water wire not only exhibits enormous dielectric anomalies at approximately 175 and 277 K, respectively, but also undergoes a spontaneous transition between "1D liquid" and "1D ferroelectric ice" at approximately 277 K. Hitherto unrevealed properties of the 1D water wire will be valuable to the understanding of anomalous properties of water and synthesis of novel ferroelectric materials.	Water	300-305	leiomodin 1	Homo sapiens	196-199
21321232-7	2011	In stark contrast to the bulk, this 1D water wire not only exhibits enormous dielectric anomalies at approximately 175 and 277 K, respectively, but also undergoes a spontaneous transition between "1D liquid" and "1D ferroelectric ice" at approximately 277 K. Hitherto unrevealed properties of the 1D water wire will be valuable to the understanding of anomalous properties of water and synthesis of novel ferroelectric materials.	Water	300-305	leiomodin 1	Homo sapiens	212-215
25657739-3	2014	In this study, we investigated the effects of oral intake of thermomineral water from the Atomic Spa Gornja Trepca on nerve regeneration in a 3-month-old mouse model of spinal cord injury.	Water	75-80	surfactant associated protein A1	Mus musculus	97-100
21469708-2	2011	A variety of nanostructured oxides including TiO(2), SnO(2) and organosilicates are formed using sol-gel and nanoparticle precursors by way of molding with water-soluble polymeric templates generated from silicon masters.	Water	156-161	strawberry notch homolog 1	Homo sapiens	53-56
25298526-1	2014	The proximal tubule Na(+)/H(+) exchanger 3 (NHE3), located in the apical dense microvilli (brush border), plays a major role in the reabsorption of NaCl and water in the renal proximal tubule.	Water	157-162	solute carrier family 9 member A3	Rattus norvegicus	20-42
21310231-7	2011	On the other hand, supplementation of cysteine in the drinking water of the CSE-KO mice significantly increased plasma cysteine and glutathione levels.	Water	63-68	cystathionase (cystathionine gamma-lyase)	Mus musculus	76-79
20959966-1	2011	INTRODUCTION: In rats, activation of medial septum (MS) 5-HT(1A) receptors with the 5-HT(1A)/5-HT(7) receptor agonist 8-OH-DPAT disrupts encoding and consolidation, but not retrieval of a spatial memory in the water maze task.	Water	210-215	5-hydroxytryptamine receptor 1A	Rattus norvegicus	56-63
21322734-3	2011	A MD simulation of the LAO in explicit water was performed for 600 ns, in which slow and large-amplitude domain motions of the LAO were observed.	Water	39-44	interleukin 4 induced 1	Homo sapiens	23-26
25298526-1	2014	The proximal tubule Na(+)/H(+) exchanger 3 (NHE3), located in the apical dense microvilli (brush border), plays a major role in the reabsorption of NaCl and water in the renal proximal tubule.	Water	157-162	solute carrier family 9 member A3	Rattus norvegicus	44-48
21322734-3	2011	A MD simulation of the LAO in explicit water was performed for 600 ns, in which slow and large-amplitude domain motions of the LAO were observed.	Water	39-44	interleukin 4 induced 1	Homo sapiens	127-130
21489794-3	2011	PHB nanoparticles loaded with model drug molecule, Nile red, were prepared through oil-in-water emulsion solvent evaporation method and the surface of nanoparticles were functionalized with tumor-specific ligand, RGD4C, fused with PHA synthase that drove the coupling reaction.	Water	90-95	prohibitin 1	Homo sapiens	0-3
25078898-10	2014	In contrast to their wild-type counterparts, 12R-LOX-deficient skin equivalents showed abnormal vesicular structures in the upper epidermal layers correlating with altered lipid composition and increased transepidermal water loss, comparable with 12R-LOX-deficient mice.	Water	219-224	arachidonate 12-lipoxygenase, 12R type	Mus musculus	45-52
21333304-1	2011	Two new water soluble dendronized polymers (PLn) from acrylate Behera amine monomer of different molecular weights were successfully synthesized.	Water	8-13	phospholamban	Homo sapiens	44-47
21222441-6	2011	Similar to the rotation, the low water content mixtures obey the SE equation and show the same proportionality to eta/T as the temperature-dependent data.	Water	33-38	endothelin receptor type A	Homo sapiens	114-117
25371738-1	2014	Aquaporin-1 (AQP-1) is expressed in lung endothelial cells and regulates water transport; thus, AQP-1 plays an important role in a number of edema-associated lung diseases.	Water	73-78	aquaporin 1	Rattus norvegicus	0-11
21386137-3	2011	Manganese superoxide dismutase (MnSOD) is the primary mitochondrial ROS scavenging enzyme that converts superoxide to hydrogen peroxide, which is subsequently converted to water by catalase and other peroxidases.	Water	172-177	superoxide dismutase 2	Homo sapiens	0-30
21386137-3	2011	Manganese superoxide dismutase (MnSOD) is the primary mitochondrial ROS scavenging enzyme that converts superoxide to hydrogen peroxide, which is subsequently converted to water by catalase and other peroxidases.	Water	172-177	superoxide dismutase 2	Homo sapiens	32-37
21092980-5	2011	Arylation with Ar-COOH or Ar-SO(3)H leads to the formation of stable colloidal solutions in water and physiological media (i.e. PBS buffer), an important prerequisite for biomedical applications.	Water	92-97	cholinergic receptor muscarinic 3	Homo sapiens	128-131
21244427-9	2011	In addition, PACAP prevented the decrease of mitochondrial activity and caspase 3 activation induced by H(2)O(2).	Water	104-109	adenylate cyclase activating polypeptide 1	Rattus norvegicus	13-18
21244427-9	2011	In addition, PACAP prevented the decrease of mitochondrial activity and caspase 3 activation induced by H(2)O(2).	Water	104-109	caspase 3	Rattus norvegicus	72-81
25371738-1	2014	Aquaporin-1 (AQP-1) is expressed in lung endothelial cells and regulates water transport; thus, AQP-1 plays an important role in a number of edema-associated lung diseases.	Water	73-78	aquaporin 1	Rattus norvegicus	13-18
25371738-1	2014	Aquaporin-1 (AQP-1) is expressed in lung endothelial cells and regulates water transport; thus, AQP-1 plays an important role in a number of edema-associated lung diseases.	Water	73-78	aquaporin 1	Rattus norvegicus	96-101
24897173-14	2014	All water samples in which the leeches were kept before treatment were contaminated with Aeromonas spp., whereas these samples were negative after antibiotic feeding of animals.	Water	4-9	histocompatibility minor 13	Homo sapiens	99-102
21402710-7	2011	Together, these properties make this aptamer a promising candidate for the development of water-soluble, highly potent, and GluA2 subunit-selective drugs.	Water	90-95	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	124-129
21134770-0	2011	Fat-water selective excitation in balanced steady-state free precession using short spatial-spectral RF pulses.	Water	4-9	FAT atypical cadherin 1	Homo sapiens	0-3
21134770-2	2011	In the present work, the practicality of performing fat-water selective excitations using spatial-spectral (SPSP) RF pulses in bSSFP sequence is examined.	Water	56-61	FAT atypical cadherin 1	Homo sapiens	52-55
21134770-4	2011	Fat-water selective excitation using SPSP pulses was demonstrated in both phantom and human bSSFP imaging at 3T, and compared to results obtained using a two-point Dixon method.	Water	4-9	FAT atypical cadherin 1	Homo sapiens	0-3
24373834-5	2014	Alternatively, ETA receptor blocker (atrasentan, 5 mg kg(-1) day(-1) in drinking water) was added to the combined RAS blockade.	Water	81-86	endothelin receptor type A	Rattus norvegicus	15-18
21263408-8	2011	Using test of multiple correlation a statistically significant correlation between X-ray signs of water overload and NT pro-BNP concentration was shown, p &lt; 0.05.	Water	98-103	natriuretic peptide B	Homo sapiens	124-127
21263408-9	2011	CONCLUSION: Measurement of NT pro-BNP was increased in the beginning of water overload in patients with CKD.	Water	72-77	natriuretic peptide B	Homo sapiens	34-37
21263408-11	2011	NT pro-BNP was a useful parameter in estimation of water overload in these patients.	Water	51-56	natriuretic peptide B	Homo sapiens	7-10
21135737-2	2011	AQP1 is a water channel found in the choroid plexus (CP), and AQP4 is expressed at the brain-CSF interfaces and astrocytic end feet; excessive fluid accumulation may involve expression of changes in these AQPs during various stages of hydrocephalus.	Water	10-15	aquaporin 1	Rattus norvegicus	0-4
21047522-8	2011	Deletion of MMP-9 decreased the levels of endostatin in both water- and DSS-treated MMP-9 KO mice.	Water	61-66	matrix metallopeptidase 9	Mus musculus	12-17
22254490-0	2011	Modeling of aquaporin 1-mediated transmural water transport and the resulting oncotic paradox.	Water	44-49	aquaporin 1	Rattus norvegicus	12-23
22254490-2	2011	The discovery of the presence of aquaporin-1 (AQP) in aortic endothelial cells suggests a new possibility of water transport across the endothelial cell (EC), alongside the generally accepted paracellular route.	Water	109-114	aquaporin 1	Rattus norvegicus	33-44
22254490-2	2011	The discovery of the presence of aquaporin-1 (AQP) in aortic endothelial cells suggests a new possibility of water transport across the endothelial cell (EC), alongside the generally accepted paracellular route.	Water	109-114	aquaporin 1	Rattus norvegicus	46-49
20943249-7	2011	PCA 1, 2 and 3 reflected the influence of natural biochemical processes, atmospheric deposition and runoff respectively on lake water chemistry.	Water	128-133	prostate cancer associated transcript 1	Homo sapiens	0-14
21056684-5	2011	Aquaglyceroporin 7, permeable to water, glycerol and urea, is expressed in pancreatic beta-cells and was recently described as being involved in the control of insulin secretion.	Water	33-38	aquaporin 7	Homo sapiens	0-18
21329570-7	2011	The results indicated that 1,2-DCE induced abnormal histopathology, and significantly higher water content were confirmed in the cerebral cortex of toxic animal model in a dose- and time-dependent manner.	Water	93-98	24-dehydrocholesterol reductase	Homo sapiens	31-34
22174656-2	2011	SME exhibited scavenging activity toward the 1,1-diphenyl-2-picrylhydrazyl radicals and hydrogen peroxide (H(2)O(2)) and UVB-induced intracellular reactive oxygen species (ROS).	Water	107-112	small nuclear ribonucleoprotein polypeptide E	Homo sapiens	0-3
22072871-4	2011	RESULTS: The inclusion complexes of G5.NHAc-FI-FA/CA4 formed were stable and are able to significantly improve the water solubility of CA4 from 11.8 to 240 mug/mL.	Water	115-120	carbonic anhydrase 4	Homo sapiens	50-53
22072871-4	2011	RESULTS: The inclusion complexes of G5.NHAc-FI-FA/CA4 formed were stable and are able to significantly improve the water solubility of CA4 from 11.8 to 240 mug/mL.	Water	115-120	carbonic anhydrase 4	Homo sapiens	135-138
21535666-1	2011	Recent research has demonstrated that the critical relative humidity (RHc) values, obtained using automatic water vapor sorption instruments, can be used to detect the glassy to rubbery transition.	Water	108-113	HCL2	Homo sapiens	70-73
21535666-2	2011	However, reported time dependency of these RHc values suggests that additional research be carried out using equilibrium water vapor sorption methods.	Water	121-126	HCL2	Homo sapiens	43-46
21535666-11	2011	However, reported time dependency of these RHc values suggests that additional research be carried out using equilibrium water vapor sorption methods.	Water	121-126	HCL2	Homo sapiens	43-46
21535679-3	2011	Thus, the central objective of this study was to investigate the relationship between the glass transition temperature (Tg), determined using thermal methods, and the RHc obtained using an automatic water vapor sorption instrument.	Water	199-204	HCL2	Homo sapiens	167-170
21535679-14	2011	This research demonstrates that RHc values, obtained at constant temperature using an automatic water vapor sorption instrument, can be used to detect the glassy to rubbery transition and are similar to the Tg values obtained at constant %RH, especially considering the very different approaches of these 2 methods--a transition from surface adsorption to bulk absorption (water vapor sorption) versus a step change in the heat capacity (DSC thermal method).	Water	96-101	HCL2	Homo sapiens	32-35
21184434-0	2011	Observations of different core water cluster ions Y-(H2O)n (Y = O2, HOx, NOx, COx) and magic number in atmospheric pressure negative corona discharge mass spectrometry.	Water	31-36	cytochrome c oxidase subunit 8A	Homo sapiens	78-81
21461556-0	2011	Identification of a novel function of Id-1 in mediating the anticancer responses of SAMC, a water-soluble garlic derivative, in human bladder cancer cells.	Water	92-97	inhibitor of DNA binding 1, HLH protein	Homo sapiens	38-42
21687710-7	2011	Additional controls revealed that successful subjects added water only if it was necessary to obtain the nut.	Water	60-65	NUT midline carcinoma family member 1	Homo sapiens	105-108
21195670-5	2011	Five days after the last treatment with siRNA, the levels of tgfb1 transcripts and TGFbeta1 protein were reduced when compared with control groups treated with RNase-free water or non-targeting siRNA.	Water	171-176	transforming growth factor, beta 1	Mus musculus	61-66
20638418-0	2010	On a possible dual role for the lateral septal area 5-HT(1A) receptor system in the regulation of water intake and urinary excretion.	Water	98-103	5-hydroxytryptamine receptor 1A	Rattus norvegicus	52-59
20638418-5	2010	Injections of 8-OH-DPAT (a 5-HT(1A) agonist) blocked water intake and increased urinary excretion, while pMPPF or the OT antagonist injected bilaterally before 8-OH-DPAT blocked its inhibitory effect on water intake and its diuretic effect.	Water	53-58	5-hydroxytryptamine receptor 1A	Rattus norvegicus	27-34
20638418-6	2010	In contrast, increases in extracellular sodium levels induced by the sodium channel modulator, veratridine, enhanced 5-HT(1A) responsiveness for water intake and reduced the diuretic effects induced by 8-OH-DPAT.	Water	145-150	5-hydroxytryptamine receptor 1A	Rattus norvegicus	117-124
21070033-2	2010	However, the problems of limited water solubility, high melting point, and low metabolic stability complicated the development of 1,3-disubstituted urea-based sEH inhibitors.	Water	33-38	epoxide hydrolase 2	Homo sapiens	159-162
21077660-2	2010	In this paper, the self-assembly of three short amyloid-related peptides in a water nanofilm confined on a mica substrate was studied using drying microcontact printing (D-muCP) and atomic force microscopy (AFM).	Water	78-83	MHC class I polypeptide-related sequence A	Homo sapiens	107-111
21077660-7	2010	Through AFM investigation of the formation and transformation of the peptides" supramolecular structures, we conclude that the peptides" self-assembly process was dominated by weak interactions, such as hydrophobic and electrostatic interactions and hydrogen bonding, between the peptide molecules, the mica substrate, and the water nanofilm.	Water	327-332	MHC class I polypeptide-related sequence A	Homo sapiens	303-307
21036150-5	2010	Chloro-4-nitrobenzo-2-oxa-1,3-diazole was used to identify Cys-SOH modification of Cys36 in response to H(2)O(2), tert-butyl-hydroperoxide (tert-BHP), and cumene hydroperoxide (CHP) in Orp1(WT).	Water	104-109	RP1 axonemal microtubule associated	Homo sapiens	185-189
21330051-1	2011	The selective photocatalytic degradation of charged pollutants in water was achieved on titania encapsulated into FAU-type zeolites.	Water	66-71	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	114-117
21197617-2	2011	The water channel aquaporin-1 (AQP1) is present in the pulmonary microvascular endothelium, and a number of studies suggest the importance of AQP1 as a molecular determinant of pulmonary microvascular water transport.	Water	4-9	aquaporin 1	Rattus norvegicus	18-29
21197617-2	2011	The water channel aquaporin-1 (AQP1) is present in the pulmonary microvascular endothelium, and a number of studies suggest the importance of AQP1 as a molecular determinant of pulmonary microvascular water transport.	Water	4-9	aquaporin 1	Rattus norvegicus	31-35
21556222-7	2011	The water fraction of hawthorn fruit was determined to be safe and significantly inhibited NO production in LPS-stimulated RAW 264.7 cells and suppressed COX-2, TNF-alpha, IL-1beta, and IL-6 expression.	Water	4-9	prostaglandin-endoperoxide synthase 2	Mus musculus	154-159
21556222-8	2011	The observed anti-inflammatory effects of the water fraction of hawthorn fruit might be attributed to the down-regulation of COX-2, TNF-alpha, IL-1beta, and IL-6 expression in LPS-stimulated RAW 264.7 cells.	Water	46-51	prostaglandin-endoperoxide synthase 2	Mus musculus	125-130
21332241-1	2011	The amino acid-based anionic surfactant, N-dodecanoylglutamic acid (designated as LAD), when neutralized with 2-aminoethanol (MEA), 2,2"-iminodiethanol (DEA), or 2,2",2""-nitrilotriethanol (TEA) forms globular type of micelles in aqueous system at 25  C, and the viscosity of each solution is very close to that of pure water.	Water	320-325	dihydrolipoamide dehydrogenase	Homo sapiens	82-85
21111698-3	2011	Here we describe a rapid, straightforward, and easy protocol for PCR in a water-in-oil emulsion (ePCR) including sample recovery by DNA purification.	Water	74-79	protein C receptor	Homo sapiens	97-101
21194724-4	2011	It was observed that: (1) reactive oxygen species levels were lower in COR and IP than in the control group; (2) glutamate-cysteine ligase (catalytic subunit) expression was higher in COR than in other sites; (3) exposure to all water samples affected long-term memory (LTM) when compared to control group.	Water	229-234	glutamate-cysteine ligase, catalytic subunit	Danio rerio	113-158
21235533-0	2011	Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1.	Water	144-149	proteolipid protein (myelin) 1	Mus musculus	49-68
21235533-0	2011	Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1.	Water	144-149	proteolipid protein (myelin) 1	Mus musculus	70-73
21205212-5	2011	The structural studies on the catalytically impaired ZmPAO-K300M mutant described here show that substrates are bound in an "out-of-register" mode and the HOH309 water molecule is absent in the enzyme-substrate complexes.	Water	162-167	polyamine oxidase 1	Zea mays	53-58
21500592-2	2011	METHODS: The bFGF-2-loaded poly (lactic-co-glycolic acid) microspheres were prepared by water/oil/water (W/O/W) double-emulsion solvent evaporation method.	Water	88-93	fibroblast growth factor 2	Rattus norvegicus	13-17
21500592-2	2011	METHODS: The bFGF-2-loaded poly (lactic-co-glycolic acid) microspheres were prepared by water/oil/water (W/O/W) double-emulsion solvent evaporation method.	Water	98-103	fibroblast growth factor 2	Rattus norvegicus	13-17
21127817-2	2011	SPR analysis allows detecting mercury(II) concentrations in aqueous systems in the picomolar range, meliorating on three orders of magnitude the EU mercury(II) detection limit in drinkable water.	Water	189-194	sepiapterin reductase	Homo sapiens	0-3
21144760-4	2011	Stability of the hCG-M (M=metal ions) complexes was investigated by dialysis with respect to triple distilled water and ringer lactate solution, which has the same composition as extracellular fluid.	Water	110-115	chorionic gonadotropin subunit beta 5	Homo sapiens	17-20
21362350-2	2011	Our study aimed to explore the dynamic changes of AQP1 in pulmonary water metabolism in rats following traumatic brain injury (TBI) and the protective effect provided by shenmai injection.	Water	68-73	aquaporin 1	Rattus norvegicus	50-54
21362350-13	2011	CONCLUSIONS: The decreased AQP1 expression may be involved in the increased lung water content and dysfunction of pulmonary water metabolism following TBI.	Water	81-86	aquaporin 1	Rattus norvegicus	27-31
21362350-14	2011	The treatment with SMI could improve water metabolism by promoting AQP1 expression.	Water	37-42	aquaporin 1	Rattus norvegicus	67-71
21132547-1	2011	Improving access to clean water has the potential to make a major contribution toward poverty reduction in rural communities of Lao P.D.R.	Water	26-31	interleukin 4 induced 1	Homo sapiens	128-131
21263408-1	2011	AIM: To analyze usefulness of measurement amino-terminal pro-B type natriuretic peptide of (NT pro-BNP) as the one of parameters of water overload in patients with chronic kidney diseases.	Water	132-137	natriuretic peptide B	Homo sapiens	99-102
21263408-5	2011	Water overload was analyzed using chest x-ray in relation with concentration of NT pro-BNP in the blood.	Water	0-5	natriuretic peptide B	Homo sapiens	87-90
21145225-3	2011	AuPt-Ch-IL/GCE electrocatalyzed the reduction of H(2)O(2) and thus was suitable for the preparation of biosensors.	Water	49-54	glycine cleavage system protein H	Homo sapiens	0-14
21117699-10	2011	Removal of the final traces of water or ammonia by heating results in decomposition of the compounds to Pd and Pt metal, or in the case of the mixed-metal cyanide, the alloy, Pd(1/2)Pt(1/2), making it impossible to prepare the simple cyanides, Pd(CN)(2), Pt(CN)(2), or Pd(1/2)Pt(1/2)(CN)(2), by this method.	Water	31-36	programmed cell death 1	Homo sapiens	175-181
21117699-10	2011	Removal of the final traces of water or ammonia by heating results in decomposition of the compounds to Pd and Pt metal, or in the case of the mixed-metal cyanide, the alloy, Pd(1/2)Pt(1/2), making it impossible to prepare the simple cyanides, Pd(CN)(2), Pt(CN)(2), or Pd(1/2)Pt(1/2)(CN)(2), by this method.	Water	31-36	programmed cell death 1	Homo sapiens	269-275
22254490-4	2011	However, given the isotonic lumen, this AQP-mediated pure water inflow into the arterial subendothelial intima (SI) should set up an oncotic pressure gradient that opposes the AP-driven flow through the cell.	Water	58-63	aquaporin 1	Rattus norvegicus	40-43
21517005-0	2011	Estrogen-related receptor gamma disruption of source water and drinking water treatment processes extracts.	Water	53-58	estrogen related receptor gamma	Homo sapiens	0-31
21517005-11	2011	To our knowledge, the occurrence of ERRgamma disruption activities on source and drinking water in vitro had not been reported previously.	Water	90-95	estrogen related receptor gamma	Homo sapiens	36-44
21076345-0	2011	Regional partition coefficient of water in patients with cerebrovascular disease and its effect on rCBF assessment.	Water	34-39	CCAAT/enhancer binding protein zeta	Rattus norvegicus	99-103
21076345-1	2011	OBJECTIVE: Cerebral blood flow (CBF) estimation with C15O2 PET usually assumes a single tissue compartment model and a fixed brain-blood partition coefficient of water.	Water	162-167	CCAAT/enhancer binding protein zeta	Rattus norvegicus	32-35
21076345-3	2011	The purpose of this study was to investigate the changes in the partition coefficient of water in pathological regions and its effect on regional CBF assessment.	Water	89-94	CCAAT/enhancer binding protein zeta	Rattus norvegicus	146-149
21887296-5	2011	Acclimation to low-Ca(2+) fresh water stimulated Ca(2+) influx and expression of epithelial calcium channel (ecac), 11beta-hydroxylase and the glucocorticoid receptor (gr).	Water	32-37	transient receptor potential cation channel, subfamily V, member 6	Danio rerio	109-113
21629646-10	2011	CONCLUSIONS/SIGNIFICANCE: We provide the most highly resolved structure of a tRNA(Sec) molecule to date and assessed the influence of water molecules and metal ions on the molecule"s conformation and dynamics.	Water	134-139	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	77-86
21058708-7	2010	Time-resolved spectroscopy, ranging from femtoseconds to minutes, was used to investigate the nature of the photoactivation of C(alpha)-H bond cleavage in PLP-amino acid Schiff bases both in water and bound to AAT.	Water	191-196	pyridoxal phosphatase	Homo sapiens	155-158
21058708-8	2010	Unlike the thermal pathway, the photoactivation pathway involves a triplet state with a C(alpha)-H pK(a) that is estimated to be between 11 and 19 units lower than the ground state for the PLP-Val Schiff base in water.	Water	212-217	pyridoxal phosphatase	Homo sapiens	189-192
25393475-3	2014	In this study, we focused on the Angiotensin II type 1 receptor (AT1R), which belongs to the GPCR family and has an essential role in the control of blood pressure and water homeostasis.	Water	168-173	angiotensin II receptor type 1	Homo sapiens	33-63
20950836-1	2011	A collective parameter and a toxicity indicator for all the halogenated organic disinfection byproducts in a water sample is total organic halogen (TOX), which can be differentiated as total organic chlorine (TOCl), total organic bromine (TOBr) and total organic iodine.	Water	109-114	thymocyte selection associated high mobility group box	Homo sapiens	148-151
25393475-3	2014	In this study, we focused on the Angiotensin II type 1 receptor (AT1R), which belongs to the GPCR family and has an essential role in the control of blood pressure and water homeostasis.	Water	168-173	angiotensin II receptor type 1	Homo sapiens	65-69
20950836-2	2011	The TOX method involves concentration of organic halogens from water by adsorption onto activated carbon (AC).	Water	63-68	thymocyte selection associated high mobility group box	Homo sapiens	4-7
25325899-7	2014	For facilitating the conjugation, hydrophobic nano-FAp was made water soluble via o-phosphoethanolamine (PEA) coating, which further provides conjugating sites for QDs to anchor.	Water	64-69	fibroblast activation protein alpha	Homo sapiens	51-54
21866770-1	2011	Cellulose acetate/ polyacrylonitrile (CA/PAN) membranes were prepared and used to separate pyridine / water mixtures by pervaporation.	Water	102-107	adenosine deaminase 2	Homo sapiens	0-44
25402879-1	2014	A new nonaqueous and abrasive-free magnetorheological finishing (MRF) method is adopted for processing potassium dihydrogen phosphate (KDP) crystal due to its low hardness, high brittleness, temperature sensitivity, and water solubility.	Water	220-225	WNK lysine deficient protein kinase 1	Homo sapiens	135-138
21086984-7	2010	The redox titration of 1 by Ir(IV) and electrochemical data suggest that under basic conditions the reduction potential for the half-reaction [Fe(IV)L(=O)(OH(2))](2-) + e(-) + H(2)O   [Fe(III)L(OH)(OH(2))](2-) + OH(-) is close to 0.87 V (vs NHE).	Water	155-161	solute carrier family 9 member C1	Homo sapiens	241-244
21086984-7	2010	The redox titration of 1 by Ir(IV) and electrochemical data suggest that under basic conditions the reduction potential for the half-reaction [Fe(IV)L(=O)(OH(2))](2-) + e(-) + H(2)O   [Fe(III)L(OH)(OH(2))](2-) + OH(-) is close to 0.87 V (vs NHE).	Water	198-204	solute carrier family 9 member C1	Homo sapiens	241-244
21077627-2	2010	The triureas (L(1), L(2)) show stronger binding of sulfate than tetraureas (L(3), L(4)) in DMSO because of their better conformational complementarity with sulfate, while the tetraureas display better "water tolerance" benefiting from the chelate effect and hydrophobic effect.	Water	202-207	immunoglobulin kappa variable 3-15	Homo sapiens	20-24
21098298-4	2010	Using molecular dynamics simulations with three force fields we show that spontaneous formation of two ordered one-dimensional water wires in the pore between the two sheets of the Sup35 protofilaments results in long-lived structures, which are stabilized by a network of hydrogen bonds between the water molecules in the wires and the polar side chains in the beta-sheet.	Water	127-132	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	181-186
21098298-4	2010	Using molecular dynamics simulations with three force fields we show that spontaneous formation of two ordered one-dimensional water wires in the pore between the two sheets of the Sup35 protofilaments results in long-lived structures, which are stabilized by a network of hydrogen bonds between the water molecules in the wires and the polar side chains in the beta-sheet.	Water	300-305	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	181-186
20667715-3	2010	The re-oxidation capacity of partially reduced heptamolybdo-pentavanado-phosphate polyanion (HPA-5(red) or heteropoly blue) by ozone in water and aqueous acetone solution has been examined under conditions simulating pulp bleaching process.	Water	136-141	integrin subunit alpha 2	Homo sapiens	93-98
20667715-7	2010	Addition of organic solvent was shown to have a favorable effect on HPA-5(red) re-oxidation by ozone (k of 0.29 min(-1) vs. 0.43 min(-1) for ozonation, respectively, in water and 10%v/v acetone solution; pH 2), being evidently the principal reason for high efficiency of solvent-assisted HPA/O(3) pulp bleaching approach.	Water	169-174	integrin subunit alpha 2	Homo sapiens	68-73
20709120-8	2010	In view of the absorption differences of insulin between 20%, 50% water-containing microemulsions and an aqueous solution obtained in vitro and in vivo, it has been concluded that the acceleration in the intramucosal transport process is the result of encapsulating insulin within the nano-droplet clusters of a W/O microemulsion, while the microemulsion ingredients seems to have no direct role.	Water	66-71	insulin	Oryctolagus cuniculus	41-48
20709120-8	2010	In view of the absorption differences of insulin between 20%, 50% water-containing microemulsions and an aqueous solution obtained in vitro and in vivo, it has been concluded that the acceleration in the intramucosal transport process is the result of encapsulating insulin within the nano-droplet clusters of a W/O microemulsion, while the microemulsion ingredients seems to have no direct role.	Water	66-71	insulin	Oryctolagus cuniculus	266-273
21121287-4	2010	KhK solutions exhibited a random coil to helical transition when solvent conditions were changed from water to a trifluorethanol/water solution at acidic pH.	Water	102-107	ketohexokinase	Homo sapiens	0-3
21121287-4	2010	KhK solutions exhibited a random coil to helical transition when solvent conditions were changed from water to a trifluorethanol/water solution at acidic pH.	Water	129-134	ketohexokinase	Homo sapiens	0-3
21103359-8	2010	Consistent with the increased accumulation of alpha-syn and alterations in mGluR5 in cognitive- and motor-associated brain regions, these mice displayed impaired performance in the water maze and pole test, these behavioral alterations were reversed with the mGluR5 antagonist, MPEP.	Water	181-186	glutamate receptor, ionotropic, kainate 1	Mus musculus	259-265
20580228-6	2010	In the SmgB, correlation coefficients of 91% and 87% were obtained between lipolytic activity and oil in water and water in oil emulsifying activities, respectively.	Water	105-110	sterile alpha motif domain containing 4B	Homo sapiens	7-11
20580228-6	2010	In the SmgB, correlation coefficients of 91% and 87% were obtained between lipolytic activity and oil in water and water in oil emulsifying activities, respectively.	Water	115-120	sterile alpha motif domain containing 4B	Homo sapiens	7-11
20820615-8	2010	In all compounds, except those of [Na(H(2)O)(3){eta(6)-C(6)H(5)COO}Cr(CO)(3)], the alkali metal atoms form isocarbonyl bridges to the chromium atoms.	Water	38-43	endothelin receptor type A	Homo sapiens	48-51
20925360-3	2010	The binding energies between both sterols and Osh4 were dominated by van der Waals interactions with residues within the sterol binding pocket, and were further stabilized by water-mediated interactions with polar residues at the bottom of the binding pocket (W46, Q96, Y97, N165, Q181).	Water	175-180	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	46-50
20639513-1	2010	Expression of aquaporin-1 (AQP1) and -2 (AQP2) channels in the kidney are critical for the maintenance of water homeostasis and the operation of the urinary concentrating mechanism.	Water	106-111	aquaporin 1	Mus musculus	14-39
20959616-6	2010	Aquaporin (AQP) 1 is the only AQP present in these cells, and its deletion in AQP1 null mice significantly affects cell osmotic permeability (by ~40%) but fluid transport much less (~20%), which militates against the presence of sizable water movements across the cell.	Water	237-242	aquaporin 1	Mus musculus	11-17
20959616-6	2010	Aquaporin (AQP) 1 is the only AQP present in these cells, and its deletion in AQP1 null mice significantly affects cell osmotic permeability (by ~40%) but fluid transport much less (~20%), which militates against the presence of sizable water movements across the cell.	Water	237-242	aquaporin 1	Mus musculus	78-82
20683521-7	2010	Interestingly, compounds 1-3 exhibit water-induced reversible crystal-to-amorphous transformations with chromotropism and compound 4 also shows water-induced reversible structural phase transformation confirmed by spectroscopic techniques, elemental analyses, TGA, and XRPD.	Water	144-149	T-box transcription factor 1	Homo sapiens	260-263
20813950-0	2010	Graphene visualizes the first water adlayers on mica at ambient conditions.	Water	30-35	MHC class I polypeptide-related sequence A	Homo sapiens	48-52
20813950-3	2010	Water adlayers grew epitaxially on the mica substrate in a layer-by-layer fashion.	Water	0-5	MHC class I polypeptide-related sequence A	Homo sapiens	39-43
20525688-6	2010	The transport activity of the D340C mutant of Cys-less Hxt7, in which Asp(340) is replaced with Cys, was completely inhibited by pCMBS, indicating that Asp(340) is located in a water-accessible position.	Water	177-182	hexose transporter HXT7	Saccharomyces cerevisiae S288C	55-59
20695547-0	2010	Potential of mean force for K+ in thin water films on cleaved mica.	Water	39-44	MHC class I polypeptide-related sequence A	Homo sapiens	62-66
20695547-1	2010	The atomically smooth surface of cleaved K(+)-mica is a common substrate for investigations of various phenomena at the mineral-water interface.	Water	128-133	MHC class I polypeptide-related sequence A	Homo sapiens	7-11
20674861-1	2010	Water-soluble Niemann-Pick C2 (NPC2) and membrane-bound NPC1 are cholesterol-binding lysosomal proteins required for export of lipoprotein-derived cholesterol from lysosomes.	Water	0-5	NPC intracellular cholesterol transporter 2	Homo sapiens	14-29
20674861-1	2010	Water-soluble Niemann-Pick C2 (NPC2) and membrane-bound NPC1 are cholesterol-binding lysosomal proteins required for export of lipoprotein-derived cholesterol from lysosomes.	Water	0-5	NPC intracellular cholesterol transporter 2	Homo sapiens	31-35
20735109-4	2010	Water droplet of large volume (15 muL) had a smaller sliding angle than that of small volume (3 muL) when using the contact-mode due to the role of gravity despite the existence of large adhesive force between water droplet and the coating surface, while very small sliding angles were noted when using the drip-mode because of the existence of kinetic energy.	Water	0-5	tripartite motif containing 37	Homo sapiens	34-37
20735109-4	2010	Water droplet of large volume (15 muL) had a smaller sliding angle than that of small volume (3 muL) when using the contact-mode due to the role of gravity despite the existence of large adhesive force between water droplet and the coating surface, while very small sliding angles were noted when using the drip-mode because of the existence of kinetic energy.	Water	0-5	tripartite motif containing 37	Homo sapiens	96-99
20304634-2	2010	The selective water adsorption was conducted in a fixed-bed absorber packed with ZSG-1 to find the optimum conditions yielding 99.7 wt% anhydrous ethanol with high efficiency.	Water	14-19	sarcoglycan zeta	Homo sapiens	81-86
20362052-6	2010	Podocytes treated for 20min with H(2)O(2) (10(-4)M), which mimics reactive oxygen species generation by cells challenged by hyperglycemic or enhanced Pgc conditions, significantly increased the levels of active p38 MAPK, AKT, JNK and ERK1/2.	Water	33-38	mitogen-activated protein kinase 14	Mus musculus	211-214
20362052-6	2010	Podocytes treated for 20min with H(2)O(2) (10(-4)M), which mimics reactive oxygen species generation by cells challenged by hyperglycemic or enhanced Pgc conditions, significantly increased the levels of active p38 MAPK, AKT, JNK and ERK1/2.	Water	33-38	mitogen-activated protein kinase 3	Mus musculus	234-240
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Water	2-7	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	32-36
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Water	2-7	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	107-111
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Water	2-7	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	107-111
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Water	2-7	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	107-111
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Water	2-7	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	107-111
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Water	2-7	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	107-111
20621191-2	2010	In the present study, optimal hybridization conditions were achieved for quantifying the mRNA expression of histidine decarboxylase (HDC) by a number of alterations in a routine protocol, which included (1) during purification of the oligo-probes, glycogen was omitted as a carrier for precipitation, (2) after precipitation, the labeled probe contained within the pellet was first dissolved in water instead of in hybridization buffer (HBF), (3) during hybridization, the dithiothreitol (DTT) concentration was increased from 200 to 800 mM in HBF, and (4) stringencies during hybridization and post-hybridization washes were increased by increasing the temperature.	Water	395-400	histidine decarboxylase	Homo sapiens	108-131
20621191-2	2010	In the present study, optimal hybridization conditions were achieved for quantifying the mRNA expression of histidine decarboxylase (HDC) by a number of alterations in a routine protocol, which included (1) during purification of the oligo-probes, glycogen was omitted as a carrier for precipitation, (2) after precipitation, the labeled probe contained within the pellet was first dissolved in water instead of in hybridization buffer (HBF), (3) during hybridization, the dithiothreitol (DTT) concentration was increased from 200 to 800 mM in HBF, and (4) stringencies during hybridization and post-hybridization washes were increased by increasing the temperature.	Water	395-400	histidine decarboxylase	Homo sapiens	133-136
21139433-4	2010	Analysis of BAX inhibitor-1 (AtBI1) expression and the phenotypic response of atbi1-1 mutant under the severe water stress revealed that AtBI1 and the endoplasmic reticulum (ER) stress response pathway modulate water stress-induced PCD.	Water	110-115	BAX inhibitor 1	Arabidopsis thaliana	78-83
21139433-4	2010	Analysis of BAX inhibitor-1 (AtBI1) expression and the phenotypic response of atbi1-1 mutant under the severe water stress revealed that AtBI1 and the endoplasmic reticulum (ER) stress response pathway modulate water stress-induced PCD.	Water	110-115	BAX inhibitor 1	Arabidopsis thaliana	137-142
20856958-8	2010	We also find that one conserved water has a much stronger interaction with the protein in GluA2, GluK1 and GluK2 compared to the GluN2A receptor.	Water	32-37	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	90-95
20856958-9	2010	The position of this water molecule is such that it can influence the dynamics of the proposed switch in the GluA2 and GluK1/2 receptors.	Water	21-26	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	109-114
21085499-5	2010	Free-energy changes along the reaction coordinate for S(N)2 methyl transfer catalysed by the enzyme catechol-O-methyl transferase are described and compared with those for a model reaction in water, as computed by hybrid quantum-mechanical/molecular-mechanical molecular dynamics simulations.	Water	192-197	catechol-O-methyltransferase	Homo sapiens	100-129
20811008-6	2010	Messenger RNA for AQP-x3, a homolog of AQP-h3, could be identified by RT-PCR from the hindlimb, pectoral, and pelvic regions of the ventral skin of Xenopus laevis, although AVT had no effect on water permeability.	Water	194-199	aquaporin-x3	Xenopus laevis	18-24
21170876-2	2010	Several lines of evidence have demonstrated that the water channel aquaporin-1 (AQP1) corresponds to the ultrasmall pore predicted by the modelization of peritoneal transport.	Water	53-58	aquaporin 1	Mus musculus	80-84
21170876-3	2010	Proof-of-principle studies have shown that up-regulation of the expression of AQP1 in peritoneal capillaries is reflected by increased water permeability and ultrafiltration, without affecting the osmotic gradient and the permeability for small solutes.	Water	135-140	aquaporin 1	Mus musculus	78-82
21170876-4	2010	Inversely, studies in Aqp1 mice have shown that haploinsufficiency in AQP1 is reflected by significant attenuation of water transport.	Water	118-123	aquaporin 1	Mus musculus	70-74
20848345-10	2010	The altered centrally applied AngII response in SHR associated with increased hypothalamic JAK-2/SOCS-3 expression may suggest that abnormal regulation of the central angiotensin pathways may contribute to dysfunction of water-electrolyte homeostasis in SHR.	Water	221-226	suppressor of cytokine signaling 3	Rattus norvegicus	97-103
20947024-4	2010	Both RRM1 in RRM1-RNA and RRM2 in RRM1/2-RNA complexes use similar principles to target UGU(U/G) elements, with recognition mediated by face-to-edge stacking and water-mediated hydrogen-bonding networks.	Water	162-167	ribonucleotide reductase catalytic subunit M1	Homo sapiens	5-9
20947024-4	2010	Both RRM1 in RRM1-RNA and RRM2 in RRM1/2-RNA complexes use similar principles to target UGU(U/G) elements, with recognition mediated by face-to-edge stacking and water-mediated hydrogen-bonding networks.	Water	162-167	ribonucleotide reductase catalytic subunit M1	Homo sapiens	13-17
20947024-4	2010	Both RRM1 in RRM1-RNA and RRM2 in RRM1/2-RNA complexes use similar principles to target UGU(U/G) elements, with recognition mediated by face-to-edge stacking and water-mediated hydrogen-bonding networks.	Water	162-167	ribonucleotide reductase catalytic subunit M1	Homo sapiens	34-40
20643113-1	2010	To investigate the effect of co-exposure to cadmium (Cd) and selenium (Se) on selenoprotein P (SelP) and phospholipid hydroperoxide glutathione peroxidase (GPx4) gene expression in testis and to evaluate their possible involvement in Cd-induced testicular pathophysiology, male rats received either tap water, Cd or Cd+Se in their drinking water for 5 weeks.	Water	303-308	glutathione peroxidase 4	Rattus norvegicus	156-160
20643113-1	2010	To investigate the effect of co-exposure to cadmium (Cd) and selenium (Se) on selenoprotein P (SelP) and phospholipid hydroperoxide glutathione peroxidase (GPx4) gene expression in testis and to evaluate their possible involvement in Cd-induced testicular pathophysiology, male rats received either tap water, Cd or Cd+Se in their drinking water for 5 weeks.	Water	340-345	glutathione peroxidase 4	Rattus norvegicus	156-160
20549748-2	2010	The K(+)-Cl(-) cotransporter (KCC) family includes four isoforms (KCC1-4) that play an important role in the maintenance of cellular osmotic homeostasis via the coupled electroneutral movement of K(+) and Cl(-) with concurrent water flux.	Water	227-232	solute carrier family 12, member 4	Mus musculus	66-72
19840149-13	2010	In conclusion, AQP7 and AQP8 were identified in human spermatozoa and could play a role in glycerol metabolism and water transport respectively.	Water	115-120	aquaporin 7	Homo sapiens	15-19
25443875-5	2014	Thienopyridine-SH + H(+ (Stomach)) +  [Formula: see text]   Thienopyridine-SNO + H2O Thienopyridine-SNO (an S-nitrosothiol molecule) would have the potential to participate in all the reactions expected of native nitric oxide (NO) with added benefit that the NO "moiety" is protected, transportable and largely preserved from further reactive metabolism.	Water	81-84	strawberry notch homolog 1	Homo sapiens	75-78
21567589-1	2010	In this communication, beta-cyclodextrin modified quantum dots were used as a water-soluble "supramolecular" cross-linker (SCL) because of its surface"s supramolecular activity.	Water	78-83	selenocysteine lyase	Mus musculus	123-126
21567589-2	2010	The guest monomer-loaded SCL (mSCL) can be used to copolymerize with water-soluble monomers leading to transparent hybrid supramolecular hydrogels.	Water	69-74	selenocysteine lyase	Mus musculus	25-28
21567589-2	2010	The guest monomer-loaded SCL (mSCL) can be used to copolymerize with water-soluble monomers leading to transparent hybrid supramolecular hydrogels.	Water	69-74	selenocysteine lyase	Mus musculus	30-34
20525793-4	2010	Multiple explicit water molecular dynamics simulations of the H4 tail peptide into the catalytic cleft of PARP1 indicate that two stable intermolecular salt bridges hold the peptide in an orientation that allows K16 ADP-ribosylation.	Water	18-23	keratin 16	Homo sapiens	212-215
20853754-6	2010	This study reports a globally applicable approach for evaluating the spatial variation in relative risk of contaminating surface water by Cryptosporidium spp.	Water	129-134	histocompatibility minor 13	Homo sapiens	154-157
20853754-19	2010	The study demonstrated a semi-quantitative and readily implemented method for using spatial risk assessment for planning land management to reduce the risk of surface water contamination by Cryptosporidium spp.	Water	167-172	histocompatibility minor 13	Homo sapiens	206-209
25443875-5	2014	Thienopyridine-SH + H(+ (Stomach)) +  [Formula: see text]   Thienopyridine-SNO + H2O Thienopyridine-SNO (an S-nitrosothiol molecule) would have the potential to participate in all the reactions expected of native nitric oxide (NO) with added benefit that the NO "moiety" is protected, transportable and largely preserved from further reactive metabolism.	Water	81-84	strawberry notch homolog 1	Homo sapiens	100-103
25223979-5	2014	Outcomes indicate that inactivation of orexinergic receptors in the CeA attenuates flavor-taste preference in a two-bottle test (saccharin vs. water).	Water	143-148	carcinoembryonic antigen gene family 4	Rattus norvegicus	68-71
20504761-2	2010	Functionally, nod26 forms a low energy transport pathway for water, osmolytes, and NH(3) across the SM.	Water	61-66	nodulin-26	Glycine max	14-19
20831330-0	2010	Cellular network formation of hydrophobic alkanethiol capped gold nanoparticles on mica surface mediated by water islands.	Water	108-113	MHC class I polypeptide-related sequence A	Homo sapiens	83-87
20831330-2	2010	Using alkanethiol capped gold nanoparticles deposited on mica imaged under ambient and controlled water vapor conditions by atomic force microscope and in situ scanning electron microscope, respectively, we show a third mechanism in action.	Water	98-103	MHC class I polypeptide-related sequence A	Homo sapiens	57-61
25379929-4	2014	The application to the specific cases of nonpolar (101 0) facets of GaN and ZnO reveals a significant role for the structural motifs at the interface, including the degree of interface water dissociation and the dynamical fluctuations in the interface Zn-O and O-H bond orientations.	Water	185-190	gigaxonin	Homo sapiens	68-71
20686880-4	2010	Samples made of each polymer alone (0.3-1.0% w/w) or in mixture with mucin (mucin fixed at 1.0% w/w) in water were investigated while using high-resolution ultrasonic spectrometer at two different frequencies (5.2 and 8.2 MHz).	Water	104-109	LOC100508689	Homo sapiens	69-74
20226201-1	2010	A water deprived animal that ingests only water efficiently corrects its intracellular dehydration, but remains hypovolemic, in negative sodium balance, and with high plasma renin activity and angiotensin II.	Water	2-7	renin	Rattus norvegicus	174-179
20690651-7	2010	The looser structure of the CA relative to CAmb as confirmed by FTIR, TGA, and DSC analysis makes more sites accessible to water molecules, resulting in a higher water retention in CA (2.73% w/w) relative to CAmb (1.60% w/w) and an increased molecular mobility in the former due to a plasticizing effect.	Water	123-128	T-box transcription factor 1	Homo sapiens	70-73
25251378-10	2014	The NPC1(NTD) binding pocket is energetically unfavorable to conformational rearrangement of the hydrophobic ligand because it contains more water molecules near the ligand tail and amino acids with polar side chains.	Water	141-146	fuzzy planar cell polarity protein	Homo sapiens	9-12
20690651-7	2010	The looser structure of the CA relative to CAmb as confirmed by FTIR, TGA, and DSC analysis makes more sites accessible to water molecules, resulting in a higher water retention in CA (2.73% w/w) relative to CAmb (1.60% w/w) and an increased molecular mobility in the former due to a plasticizing effect.	Water	162-167	T-box transcription factor 1	Homo sapiens	70-73
25175037-1	2014	Size tunable aqueous Ag2S quantum dots emitting in the near-infrared region were synthesized through decomposition of meso-2,3-dimercaptosuccinic acid (DMSA) in water.	Water	161-166	angiotensin II receptor type 1	Homo sapiens	21-25
20353442-0	2010	Effect of a selective neutrophil elastase inhibitor on early recovery from body water imbalance after transthoracic esophagectomy.	Water	80-85	elastase, neutrophil expressed	Homo sapiens	22-41
20353442-2	2010	Esophagectomy with elective lymphadenectomy may induce excessive release of neutrophil elastase, which then promotes vascular permeability and an excessive water shift from the intravascular space to the peripheral compartment.	Water	156-161	elastase, neutrophil expressed	Homo sapiens	76-95
20628603-8	2010	Flies with reduced DTK or sNPF levels in these cells displayed decreased survival time at desiccation and starvation, as well as increased water loss at desiccation.	Water	139-144	Tachykinin	Drosophila melanogaster	19-22
20599966-4	2010	If AQP0 has only water permeability function, can the more efficient water channel AQP1 transgenically expressed in the fiber cells compensate and restore lens transparency in the AQP0 knockout (AQP0(-/-)) mouse?	Water	17-22	aquaporin 1	Mus musculus	83-87
25233063-3	2014	We measured static contact angles (thetas) made by water droplets on n-alkanethiolate SAMs with an odd (SAM(O)) or even (SAM(E)) number of carbons (average thetas range of 105.8-112.1 ).	Water	51-56	methionine adenosyltransferase 1A	Homo sapiens	86-90
20599966-6	2010	These transgenic mice (TgAQP1(+/+)) showed increase in fiber cell membrane water permeability without any morphological, anatomical or physiological defects compared to the wild type indicating that the main purpose of the shift in expression from AQP1 to AQP0 may not be to lessen the membrane water permeability.	Water	75-80	aquaporin 1	Mus musculus	25-29
20630323-8	2010	In water, the HXT2 gene was the only one of the transporter genes studied that showed significant variations.	Water	3-8	hexose transporter HXT2	Saccharomyces cerevisiae S288C	14-18
20543828-5	2010	Molecular dynamics simulations revealed water molecules in the central crevice of Hv1 model structures but not in homologous voltage-sensor domain (VSD) structures.	Water	40-45	hydrogen voltage gated channel 1	Homo sapiens	82-85
20543828-6	2010	Our results indicate that Hv1 most likely forms an internal water wire for selective proton transfer and that interactions between water molecules and S4 arginines may underlie coupling between voltage- and pH-gradient sensing.	Water	60-65	hydrogen voltage gated channel 1	Homo sapiens	26-29
20543828-6	2010	Our results indicate that Hv1 most likely forms an internal water wire for selective proton transfer and that interactions between water molecules and S4 arginines may underlie coupling between voltage- and pH-gradient sensing.	Water	131-136	hydrogen voltage gated channel 1	Homo sapiens	26-29
20664360-5	2010	Denaturation of HMGB1 with boiling water or coincubation with anti-HMGB1 antibody abrogated the induction of tolerance to LTA.	Water	35-40	high mobility group box 1	Homo sapiens	16-21
25379492-6	2014	RESULTS: SBP, DBP, mean BP (mBP), and RPP decreased significantly after water immersion, but HR was unchanged.	Water	72-77	myelin basic protein	Mus musculus	10-12
20580059-2	2010	The formation of trihalomethanes (THMs), haloacetic acids (HAAs), and total organic halide (TOX) upon chlorination of untreated water, and after conventional treatment, granular activated carbon treatment, and nanofiltration were quantified using ANNs.	Water	128-133	thymocyte selection associated high mobility group box	Homo sapiens	92-95
25379492-6	2014	RESULTS: SBP, DBP, mean BP (mBP), and RPP decreased significantly after water immersion, but HR was unchanged.	Water	72-77	myelin basic protein	Mus musculus	28-31
25264079-8	2014	Finally, an A. membranaceus water extract activated PPARgamma activity in either human embryonic kidney 293 (HEK293) or A549 cells in a PPARgamma-responsive element-containing luciferase reporter assay.	Water	28-33	peroxisome proliferator activated receptor gamma	Mus musculus	52-61
20824120-8	2010	Co-localization of AQP4 and Kir4.1 may indicate that water flux mediated by AQP4 is associated with K(+) siphoning.	Water	53-58	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	28-34
20494575-1	2010	Replacing the phenyl groups in the structure of the VMAT2 inhibitor, lobelane with either pyridyl, quinolyl or indolyl groups affords novel analogues with improved water solubility.	Water	164-169	solute carrier family 18 member A2	Homo sapiens	52-57
25264079-8	2014	Finally, an A. membranaceus water extract activated PPARgamma activity in either human embryonic kidney 293 (HEK293) or A549 cells in a PPARgamma-responsive element-containing luciferase reporter assay.	Water	28-33	peroxisome proliferator activated receptor gamma	Mus musculus	136-145
25693375-3	2014	The total concentrations of 16 PAH ranged from 81.5-8019 ng   L(-1) in underground river, 288.7-15,200 ng   L(-1) in karst springs, and 128.4-2,442 ng   L(-1) in surface water.	Water	170-175	phenylalanine hydroxylase	Homo sapiens	31-34
20421285-10	2010	Direct release of ADP/AMP from mucin granules is likely to provide a major source of airway surface adenosine to signal in a paracrine faction ciliated cell A(2b) receptors to activate ion/water secretion and appropriately hydrate goblet cell-released mucins.	Water	189-194	LOC100508689	Homo sapiens	31-36
20532327-8	2010	However, SAMs which are still crystalline in air, but less perfect, show rather amorphous spectral features under aqueous conditions indicating a strong interaction with water.	Water	170-175	methionine adenosyltransferase 1A	Homo sapiens	9-13
20672200-7	2010	The adsorption in PBS led to higher adsorbed amounts on both surfaces as compared to water.	Water	85-90	cholinergic receptor muscarinic 3	Homo sapiens	18-21
20335376-2	2010	When injected intracerebroventricularly, nesfatin-1, via a melanocortin 3/4 receptor-dependent mechanism, potently decreased both food and water intakes and elevated mean arterial pressure in a dose-related manner.	Water	139-144	nucleobindin 2	Rattus norvegicus	41-51
25693375-8	2014	The levels of ecological risk were generally moderately polluted and heavily polluted according to all detected PAH compounds in the water.	Water	133-138	phenylalanine hydroxylase	Homo sapiens	112-115
20335376-5	2010	We found that pretreatment with OVT reversed the effects of nesfatin-1 on both food and water intake and on mean arterial pressure, indicating that the central oxytocin system is a downstream mediator of these actions of nesfatin-1.	Water	88-93	nucleobindin 2	Rattus norvegicus	60-70
25099487-8	2014	o-HB forms the least hydrogen bonds and is therefore the most mobile, and p-HB, which forms the most hydrogen bonds with water, is the least mobile isomer.	Water	121-126	prohibitin 1	Homo sapiens	74-78
20335376-7	2010	Taken together, these data suggest that nesfatin-1 acts through a serial neuronal circuit, in which nesfatin-1 activates the central melanocortin system, which, in turn, acts through the central oxytocin system, leading to an inhibition of food and water intake and an increase in mean arterial pressure.	Water	249-254	nucleobindin 2	Rattus norvegicus	40-50
20335376-7	2010	Taken together, these data suggest that nesfatin-1 acts through a serial neuronal circuit, in which nesfatin-1 activates the central melanocortin system, which, in turn, acts through the central oxytocin system, leading to an inhibition of food and water intake and an increase in mean arterial pressure.	Water	249-254	nucleobindin 2	Rattus norvegicus	100-110
20677283-0	2010	Noise analysis for 3-point chemical shift-based water-fat separation with spectral modeling of fat.	Water	48-53	FAT atypical cadherin 1	Homo sapiens	54-57
20677283-1	2010	PURPOSE: To model the theoretical signal-to-noise ratio (SNR) behavior of 3-point chemical shift-based water-fat separation, using spectral modeling of fat, with experimental validation for spin-echo and gradient-echo imaging.	Water	103-108	FAT atypical cadherin 1	Homo sapiens	109-112
20677283-4	2010	Experimental validation in a fat-water phantom was performed and compared with theory.	Water	33-38	FAT atypical cadherin 1	Homo sapiens	29-32
20677283-7	2010	Spectral modeling of fat more accurately separates fat and water signals, with only a slight decrease in the SNR performance of the water-only image, although with a relatively large decrease in the fat SNR performance.	Water	59-64	FAT atypical cadherin 1	Homo sapiens	21-24
20677283-8	2010	CONCLUSION: The optimal echo combination that provides the best SNR performance for water using spectral modeling of fat is very similar to previous optimizations that modeled fat as a single peak.	Water	84-89	FAT atypical cadherin 1	Homo sapiens	117-120
19479332-4	2010	For both the water and sediment samples, MBT was generally the most predominant butyltin in these two estuaries.	Water	13-18	proteinase 3	Homo sapiens	41-44
25060953-0	2014	Remarkable luminescence enhancement of chloroplatinum(II) complexes of hexaethylene glycol methyl ether substituted 2,6-bis(benzimidazol-2"-yl)pyridine in water triggered by PF6-.	Water	155-160	sperm associated antigen 17	Homo sapiens	174-177
20331983-2	2010	In the present study we investigated the effects of bilateral lesions of the CeA on water and 0.3M NaCl intake induced by GABAergic receptor activation with bilateral injections of muscimol into the LPBN in satiated rats.	Water	84-89	carcinoembryonic antigen gene family 4	Rattus norvegicus	77-80
20331983-6	2010	The present results show that water and 0.3M NaCl intake induced by the blockade of LPBN neurons with muscimol depends on the integrity of the CeA, suggesting that facilitatory mechanisms present in the CeA are essential for water and hypertonic NaCl intake that arises after the blockade of the inhibitory mechanisms of the LPBN with muscimol.	Water	30-35	carcinoembryonic antigen gene family 4	Rattus norvegicus	143-146
20331983-6	2010	The present results show that water and 0.3M NaCl intake induced by the blockade of LPBN neurons with muscimol depends on the integrity of the CeA, suggesting that facilitatory mechanisms present in the CeA are essential for water and hypertonic NaCl intake that arises after the blockade of the inhibitory mechanisms of the LPBN with muscimol.	Water	30-35	carcinoembryonic antigen gene family 4	Rattus norvegicus	203-206
20331983-6	2010	The present results show that water and 0.3M NaCl intake induced by the blockade of LPBN neurons with muscimol depends on the integrity of the CeA, suggesting that facilitatory mechanisms present in the CeA are essential for water and hypertonic NaCl intake that arises after the blockade of the inhibitory mechanisms of the LPBN with muscimol.	Water	225-230	carcinoembryonic antigen gene family 4	Rattus norvegicus	143-146
20455020-8	2010	After exposure to H(2)O(2,) the quantity of NIH 3T3 cells transfected with pSIREN-Shuttle-DYT1-shRNA, which stained positively in the TUNEL assay, was significantly higher than the cells transfected with pSIREN-Shuttle-negative control-shRNA.	Water	18-23	torsin family 1, member A (torsin A)	Mus musculus	90-94
19879890-1	2010	Besides regulating water and electrolyte homeostasis, the mineralocorticoid receptor (MR) elicits pathophysiological effects in the renocardiovascular system.	Water	19-24	nuclear receptor subfamily 3 group C member 2	Homo sapiens	58-84
25080527-2	2014	COX-2 protein expression in the outer medulla increased approximately twofold in mice given free access to 1% NaCl in the drinking water for 3 days.	Water	131-136	cytochrome c oxidase II, mitochondrial	Mus musculus	0-5
19879890-1	2010	Besides regulating water and electrolyte homeostasis, the mineralocorticoid receptor (MR) elicits pathophysiological effects in the renocardiovascular system.	Water	19-24	nuclear receptor subfamily 3 group C member 2	Homo sapiens	86-88
20550193-3	2010	We found that TAT(48-60) is a highly dynamic and nearly random coil peptide in the lipid bilayer and inserts into the membrane-water interface near the glycerol backbone region.	Water	127-132	tyrosine aminotransferase	Homo sapiens	14-17
20331983-6	2010	The present results show that water and 0.3M NaCl intake induced by the blockade of LPBN neurons with muscimol depends on the integrity of the CeA, suggesting that facilitatory mechanisms present in the CeA are essential for water and hypertonic NaCl intake that arises after the blockade of the inhibitory mechanisms of the LPBN with muscimol.	Water	225-230	carcinoembryonic antigen gene family 4	Rattus norvegicus	203-206
20550193-5	2010	Together with the observation of strong peptide-water cross-peaks in (1)H spin diffusion spectra, these results indicate that TAT binding to the membrane-water interface is stabilized not only by electrostatic attraction to the anionic lipids but also by intermolecular hydrogen bonding with the lipid phosphates and water, which may take the role of intramolecular hydrogen bonds in canonical secondary structures.	Water	48-53	tyrosine aminotransferase	Homo sapiens	126-129
25080527-7	2014	COX-2 mRNA in primary mTAL cells increased twofold in response to media made hypertonic by the addition of NaCl (400 mosmol/kg H2O).	Water	127-130	cytochrome c oxidase II, mitochondrial	Mus musculus	0-5
20550193-5	2010	Together with the observation of strong peptide-water cross-peaks in (1)H spin diffusion spectra, these results indicate that TAT binding to the membrane-water interface is stabilized not only by electrostatic attraction to the anionic lipids but also by intermolecular hydrogen bonding with the lipid phosphates and water, which may take the role of intramolecular hydrogen bonds in canonical secondary structures.	Water	154-159	tyrosine aminotransferase	Homo sapiens	126-129
20550193-5	2010	Together with the observation of strong peptide-water cross-peaks in (1)H spin diffusion spectra, these results indicate that TAT binding to the membrane-water interface is stabilized not only by electrostatic attraction to the anionic lipids but also by intermolecular hydrogen bonding with the lipid phosphates and water, which may take the role of intramolecular hydrogen bonds in canonical secondary structures.	Water	154-159	tyrosine aminotransferase	Homo sapiens	126-129
25080527-8	2014	L-798106 increased COX-2 mRNA twofold in isotonic media and fourfold in cells exposed to 400 mosmol/kg H2O.	Water	103-106	cytochrome c oxidase II, mitochondrial	Mus musculus	19-24
20396815-3	2010	In the N6 octahedral 4 : 1-type complex [Co(II)(L10)4](ClO4)2 H2O (25) both axially coordinating N1 unidentate and equatorially bound N2,N(pyr) bidentate ligands L10 are observed.	Water	62-65	ribosomal protein L10	Homo sapiens	48-51
25056422-3	2014	Good agreement with respect to Coupled Cluster with singles and doubles excitations and perturbative triples (CCSD(T)) results is achieved for the adsorption of a single water molecule in a benchmark with two DFT-functionals (Perdew/Burke/Ernzerhof (PBE), B3LYP) and Grimme"s empirical dispersion and counterpoise corrections.	Water	170-175	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	226-261
20396815-3	2010	In the N6 octahedral 4 : 1-type complex [Co(II)(L10)4](ClO4)2 H2O (25) both axially coordinating N1 unidentate and equatorially bound N2,N(pyr) bidentate ligands L10 are observed.	Water	62-65	ribosomal protein L10	Homo sapiens	162-165
20396815-7	2010	Temperature-dependent magnetic susceptibility measurements of the iron(II) complexes 28 and 29 have shown the 3 : 1-type complex [Fe(II)(L10)3](ClO4)2 H2O (28) to be in the low-spin state over the range 300-2 K and the 2 : 1-type complex 29 to be a spin crossover compound with T(1/2) = 269 K whereas the dicyanamido-bridged complex 30 remains in the high-spin state even down to 113 K, according to X-ray diffraction data.	Water	151-154	ribosomal protein L10	Homo sapiens	137-140
20501650-1	2010	This study examined the effect of H(2)O(2) on the TRPC6 channel and its underlying mechanisms using a TRPC6 heterologous expression system.	Water	34-39	transient receptor potential cation channel subfamily C member 6	Homo sapiens	50-55
25167462-1	2014	A new water-soluble ruthenium hydride complex [Ru(H)(bpy)2(PTA)]PF6 (bpy = 2,2"-bipyridine, PTA = 1,3,5-triaza-7-phosphaadamantane) (1a) was prepared.	Water	6-11	sperm associated antigen 17	Homo sapiens	64-67
20423063-3	2010	In this paper, we look at the effects of aqueous Cl-, Br-, F-, and SO4(2-) on the water structure at the CaF2/H2O interface at a pH where surface hydroxylation has not yet occurred.	Water	82-87	CCR4-NOT transcription complex subunit 8	Homo sapiens	105-109
20423063-6	2010	This is in contrast to F- ions that directly interact with the surface and alter the water structure and bonding at the CaF2 surface in addition to screening the surface charge.	Water	85-90	CCR4-NOT transcription complex subunit 8	Homo sapiens	120-124
20400822-1	2010	We report here a template method for the fabrication of nanochannels with water-dissolvable NaNH(4)Mo(3)O(10).H(2)O nanowires as the sacrificial material.	Water	74-79	neuraminidase 1	Homo sapiens	92-96
20405902-7	2010	The least favored structure, G-3, can be eliminated by annealing the matrix to 35 K. Addition of the first water molecule to G-1 takes place at the carboxylic acid group, with simultaneous hydrogen bonding of the water molecule to the carboxylic acid (C=)O and (O-)H. The results are consistent with the predominance of this structure, although there is evidence for a small amount of a hydrated G-2 structure.	Water	107-112	BAG cochaperone 6	Homo sapiens	29-32
20405902-7	2010	The least favored structure, G-3, can be eliminated by annealing the matrix to 35 K. Addition of the first water molecule to G-1 takes place at the carboxylic acid group, with simultaneous hydrogen bonding of the water molecule to the carboxylic acid (C=)O and (O-)H. The results are consistent with the predominance of this structure, although there is evidence for a small amount of a hydrated G-2 structure.	Water	213-218	BAG cochaperone 6	Homo sapiens	29-32
25121925-2	2014	Their limit at very high concentration is near the "number of adsorption sites" of water molecules on the ions, obtained by the BET method.	Water	83-88	delta/notch like EGF repeat containing	Homo sapiens	128-131
20392098-0	2010	Experimental study of the rate of OH + HO2 --&gt; H2O + O2 at high temperatures using the reverse reaction.	Water	50-53	heme oxygenase 2	Homo sapiens	39-42
21391400-3	2010	From various parameters like pH, DO, BOD, COD, EC and minerals etc, it is concluded that the water is suitable for drinking.	Water	93-98	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	42-45
20606380-4	2010	In this study, we found that water extracts of Pruni Cortex, not Quercus Cortex showed a binding effect on estrogen receptor beta (ERbeta).	Water	29-34	estrogen receptor 2	Homo sapiens	107-129
20606380-4	2010	In this study, we found that water extracts of Pruni Cortex, not Quercus Cortex showed a binding effect on estrogen receptor beta (ERbeta).	Water	29-34	estrogen receptor 2	Homo sapiens	131-137
25096979-9	2014	Recombinant COR15 proteins are disordered in water, but fold into amphipathic alpha-helices at high osmolyte concentrations in the presence of membranes, a condition mimicking molecular crowding induced by dehydration during freezing.	Water	45-50	cold-regulated 15a	Arabidopsis thaliana	12-17
20107166-4	2010	RESULTS: TLR3-deficient and TLR2+4, TLR2+9, and TLR4+9 double-deficient mice were as susceptible to EAU as their control littermates.	Water	100-103	toll-like receptor 2	Mus musculus	28-34
20107166-9	2010	CONCLUSIONS: These results suggest that signaling of TLR2, TRL3, TRL4, and TRL9 is highly redundant in the adjuvant effect needed to induce EAU and that diverse microbial infections may contribute to the pathogenesis of diseases such as uveitis.	Water	140-143	toll-like receptor 2	Mus musculus	53-57
20184566-8	2010	RESULTS: With qRT-PCR, the rats chronically drinking ethanol plus water compared to water alone showed significantly higher levels of ENK mRNA, not only in the PVN but also in the VTA, NAcSh, NAcC, and mPFC, although not in the CeA.	Water	66-71	carcinoembryonic antigen gene family 4	Rattus norvegicus	228-231
20107166-9	2010	CONCLUSIONS: These results suggest that signaling of TLR2, TRL3, TRL4, and TRL9 is highly redundant in the adjuvant effect needed to induce EAU and that diverse microbial infections may contribute to the pathogenesis of diseases such as uveitis.	Water	140-143	tuberculosis resistance 4	Mus musculus	65-69
25075560-2	2014	However, the application of MDC is still limited in a scope of small-scale (milliliter) reactors and high-salinity-water desalination.	Water	115-120	C-C motif chemokine ligand 22	Homo sapiens	28-31
20362698-1	2010	Proper H(2)O to mucin ratio of airway mucus is important for mucociliary clearance.	Water	7-12	LOC100508689	Homo sapiens	16-21
20225050-4	2010	The most specific separation with Sil-CEA can be emphasized by the high separation factor (e.g., alpha = 1.39 in methanol-water (7:3, v/v) at 35 degrees C) for 17alpha and 17beta-estradiols, one of the most difficult pairs of isomers in chromatographic separation, whereas for two kinds of commercially available polymeric ODS columns as references alpha = 1.01, only, under the same conditions.	Water	122-127	STIL centriolar assembly protein	Homo sapiens	34-37
20184886-3	2010	The priming with hCG resulted in significant increases on percentage GVBD and ovulation, and stimulated follicular hydration, as judged by the increase in diameter, volume, water content, osmolality and Ca(2+) concentration.	Water	173-178	hypertrichosis 2 (generalised, congenital)	Homo sapiens	17-20
25075560-5	2014	Moreover, the SR-MDC kept a stable desalination performance (&gt;93%) when concentrate volume decreased from 2.4 to 0.1 L (diluate/concentrate volume ratio increased from 1:1 to 1:0.04), where only 0.875 L of nonfresh water was consumed to desalinate 1 L of saline water.	Water	218-223	C-C motif chemokine ligand 22	Homo sapiens	17-20
25075560-5	2014	Moreover, the SR-MDC kept a stable desalination performance (&gt;93%) when concentrate volume decreased from 2.4 to 0.1 L (diluate/concentrate volume ratio increased from 1:1 to 1:0.04), where only 0.875 L of nonfresh water was consumed to desalinate 1 L of saline water.	Water	265-270	C-C motif chemokine ligand 22	Homo sapiens	17-20
20423073-6	2010	Here, fully atomistic molecular dynamics simulations were used to study the effect of RCP-Cys at the water/SWNT interface.	Water	101-106	CGRP receptor component	Homo sapiens	86-89
24965793-5	2014	Selective production of ANG II in the SFO results in increased water intake but did not change blood pressure or resting metabolic rate.	Water	63-68	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	24-27
20499982-3	2010	We applied this method to the analysis of the muscovite mica/water interface and succeeded in visualizing a hydration structure that is site-specific on a crystal.	Water	61-66	MHC class I polypeptide-related sequence A	Homo sapiens	56-60
19937806-7	2010	Here we report that in chick and rat embryos these same blood vessels, which lie close to the neuroectoderm, express several molecules related to water and ion transport, namely AQP1, AQP4 and Kir4.1.	Water	146-151	aquaporin 1	Rattus norvegicus	178-182
25091984-5	2014	RESULTS: To this end, we developed an original strategy for P42 delivery, combining the properties of the cell penetrating peptide TAT from HIV with a nanostructure-based drug delivery system (Aonys  technology), to form a water-in-oil microemulsion (referred to as NP42T) allowing non-invasive per mucosal buccal/rectal administration of P42.	Water	223-228	cyclin-dependent kinase 20	Mus musculus	60-63
20163517-3	2010	Aquaporin (AQP), a water channel protein, plays a fundamental role in these water absorption/reabsorption processes.	Water	19-24	aquaporin	Xenopus laevis	0-9
20163517-3	2010	Aquaporin (AQP), a water channel protein, plays a fundamental role in these water absorption/reabsorption processes.	Water	19-24	aquaporin	Xenopus laevis	11-14
20163517-9	2010	By contrast, Xenopus has lost the ability to efficiently produce pelvic skin-type AQPa2 (AQP-x3) because Cys-273 of AQP-x3 and/or Cys-273-coding region of AQPx3 mRNA attenuate gene expression at a post-transcriptional step, presumably leading to the prevention of excessive water influx in this aquatic species.	Water	274-279	aquaporin-x3	Xenopus laevis	89-95
20501409-5	2010	RESULTS: The myocardial water content and AQP1 expression increased significantly 2 h after the burn injury, reaching the peak levels at 12 h and remaining higher than the normal level at 48 h. A significant positive correlation was found between myocardial water content and AQP1 expression in the rats (r=0.868, P&lt;0.01).	Water	24-29	aquaporin 1	Rattus norvegicus	276-280
20501409-5	2010	RESULTS: The myocardial water content and AQP1 expression increased significantly 2 h after the burn injury, reaching the peak levels at 12 h and remaining higher than the normal level at 48 h. A significant positive correlation was found between myocardial water content and AQP1 expression in the rats (r=0.868, P&lt;0.01).	Water	258-263	aquaporin 1	Rattus norvegicus	42-46
25091984-5	2014	RESULTS: To this end, we developed an original strategy for P42 delivery, combining the properties of the cell penetrating peptide TAT from HIV with a nanostructure-based drug delivery system (Aonys  technology), to form a water-in-oil microemulsion (referred to as NP42T) allowing non-invasive per mucosal buccal/rectal administration of P42.	Water	223-228	cyclin-dependent kinase 20	Mus musculus	267-270
20220109-7	2010	In addition, water uptake increased 1.6-fold in explants treated with hCG.	Water	13-18	chorionic gonadotropin subunit beta 5	Homo sapiens	70-73
20211974-9	2010	DiC8-PIP(2), a water-soluble PIP(2) analogue, inhibited OAG-induced TRPC6/C7 activity with an IC(50) of 0.74 microm.	Water	15-20	prolactin-inducible protein homolog	Oryctolagus cuniculus	5-8
20211974-9	2010	DiC8-PIP(2), a water-soluble PIP(2) analogue, inhibited OAG-induced TRPC6/C7 activity with an IC(50) of 0.74 microm.	Water	15-20	prolactin-inducible protein homolog	Oryctolagus cuniculus	29-32
24979337-0	2014	[Bmim]PF6-promoted ligandless Suzuki-Miyaura coupling reaction of potassium aryltrifluoroborates in water.	Water	100-105	sperm associated antigen 17	Homo sapiens	6-9
20337445-4	2010	Using the ssp polarization setting (s-polarized SFG, s-polarized visible, and p-polarized infrared), we observe changes in the amide I spectra of hIAPP at the air/water interface after addition of dipalmitoylphosphoglycerol (DPPG) that correspond to the lipid-induced changes in secondary structures.	Water	163-168	islet amyloid polypeptide	Homo sapiens	146-151
20337445-7	2010	Analyzing the achiral and chiral amide I spectra, we conclude that DPPG induces the misfolding of hIAPP from alpha-helical and random-coil structures to the parallel beta-sheet structure at the air/water interface.	Water	198-203	islet amyloid polypeptide	Homo sapiens	98-103
20211974-9	2010	DiC8-PIP(2), a water-soluble PIP(2) analogue, inhibited OAG-induced TRPC6/C7 activity with an IC(50) of 0.74 microm.	Water	15-20	short transient receptor potential channel 6	Oryctolagus cuniculus	68-73
24979337-1	2014	The Suzuki-Miyaura coupling reactions of potassium aryltrifluoroborates with aryl bromides in water are promoted by the addition of [bmim]PF6 using Pd(OAc)2 as a catalyst and Na2CO3 as a base under air.	Water	94-99	sperm associated antigen 17	Homo sapiens	138-141
25080850-2	2014	The present study aimed to assess if apelin-13 is an upstream signal regulation factor of aquaporin 7 (AQP7), a water-glycerol transporter present in the plasma membrane of adipocytes that plays a key role in the regulation of lipid accumulation.	Water	112-117	aquaporin 7	Homo sapiens	90-101
20182791-0	2010	Transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) participate in visceral hyperalgesia in chronic water avoidance stress rat model.	Water	119-124	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-40
20182791-0	2010	Transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) participate in visceral hyperalgesia in chronic water avoidance stress rat model.	Water	119-124	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	42-47
20357159-0	2010	Sedation with GPI 15715, a water-soluble prodrug of propofol, using target-controlled infusion in volunteers: retraction.	Water	27-32	glucose-6-phosphate isomerase	Homo sapiens	14-17
25080850-2	2014	The present study aimed to assess if apelin-13 is an upstream signal regulation factor of aquaporin 7 (AQP7), a water-glycerol transporter present in the plasma membrane of adipocytes that plays a key role in the regulation of lipid accumulation.	Water	112-117	aquaporin 7	Homo sapiens	103-107
20379888-3	2010	Based on functional data indicating their possible involvement in water holding capacity and their expression in skeletal muscle, we selected five positional candidates (ACO2, ADSL, CBY1, KCNJ4, PLA2AG6) out of 130 predicted genes in the QTL interval for further analysis.	Water	66-71	potassium inwardly rectifying channel subfamily J member 4	Sus scrofa	188-193
20182791-0	2010	Transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) participate in visceral hyperalgesia in chronic water avoidance stress rat model.	Water	119-124	ankyrin 1	Rattus norvegicus	53-62
25434113-12	2014	And a baseline separation of polar compounds such as amines and phenols on ESP was easily achieved by using common and cheap methanol-water mobile phases without buffer salts.	Water	134-139	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	75-78
20203135-2	2010	In the present study, neutral-pH hydrogen-enriched electrolyzed water (NHE-water; dissolved hydrogen: 0.90-1.14 parts per million [ppm]; oxido-reduced potential: -150 approximately -80 mV), which was prepared with a water-electrolysis apparatus equipped with a non-diaphragm cell and a highly compressed activated-carbon block, was evaluated for the mutagenic and genotoxic potentials, at concentrations up to 100% dose/plate, and for the subchronic toxicity.	Water	64-69	solute carrier family 9 member C1	Homo sapiens	71-74
20203135-2	2010	In the present study, neutral-pH hydrogen-enriched electrolyzed water (NHE-water; dissolved hydrogen: 0.90-1.14 parts per million [ppm]; oxido-reduced potential: -150 approximately -80 mV), which was prepared with a water-electrolysis apparatus equipped with a non-diaphragm cell and a highly compressed activated-carbon block, was evaluated for the mutagenic and genotoxic potentials, at concentrations up to 100% dose/plate, and for the subchronic toxicity.	Water	75-80	solute carrier family 9 member C1	Homo sapiens	71-74
20203135-2	2010	In the present study, neutral-pH hydrogen-enriched electrolyzed water (NHE-water; dissolved hydrogen: 0.90-1.14 parts per million [ppm]; oxido-reduced potential: -150 approximately -80 mV), which was prepared with a water-electrolysis apparatus equipped with a non-diaphragm cell and a highly compressed activated-carbon block, was evaluated for the mutagenic and genotoxic potentials, at concentrations up to 100% dose/plate, and for the subchronic toxicity.	Water	75-80	solute carrier family 9 member C1	Homo sapiens	71-74
20203135-3	2010	NHE-water did not induce reverse mutations in Salmonella typhimurium strains TA100, TA1535, TA98 and TA1537, and Escherichia coli strain WP2uvrA, in either the absence or presence of rat liver S9 for exogenous metabolic activation.	Water	4-9	solute carrier family 9 member C1	Homo sapiens	0-3
20203135-5	2010	To evaluate the subchronic toxicity, Crj:CD(SD) specific pathogen free (SPF)-rats were administered with NHE-water at a dose of 20 mL/kg/day for 28 days via intragastric infusion.	Water	109-114	solute carrier family 9 member C1	Homo sapiens	105-108
20203135-6	2010	NHE-water-related toxic changes were not seen in terms of any items such as clinical symptoms, body weight, food consumption, urinalysis, hematology, blood chemistry, necropsy, each organ weight and histopathology.	Water	4-9	solute carrier family 9 member C1	Homo sapiens	0-3
20203135-7	2010	Thus, the no-observable-adverse-effect level (NOAEL) for NHE-water was estimated to be greater than 20 mL/kg/day under the conditions examined, demonstrating the consistency with the expected safety for a human with a body weight of 60 kg to drink the NHE-water up to at least 1.2 L/day.	Water	61-66	solute carrier family 9 member C1	Homo sapiens	57-60
22131711-5	2010	The presentstudy has been conducted in eighty patients of major depressive disorder dividing them into four groups, A, B, C and D using Vamana therapy and Unmada Gajankusha Rasa in the dose of 250 mg twice daily with water.	Water	217-222	RAS p21 protein activator 1	Homo sapiens	173-177
24894112-1	2014	Mucin glycoproteins belong to a class of high molecular weight, heavy glycosylated, proteins that together with water, salts and lipids constitute mucous secretions.	Water	112-117	LOC100508689	Homo sapiens	0-5
20218570-2	2010	This general understanding of water structure has been structured on the basis of calorimetric analyses such as differential scanning calorimetry, DSC.	Water	30-35	desmocollin 3	Homo sapiens	147-150
20218570-3	2010	DSC is one of the most frequently used methods to analyze the water structure in polymer-water systems because the data obtained are relatively easy to interpret.	Water	62-67	desmocollin 3	Homo sapiens	0-3
20218570-3	2010	DSC is one of the most frequently used methods to analyze the water structure in polymer-water systems because the data obtained are relatively easy to interpret.	Water	89-94	desmocollin 3	Homo sapiens	0-3
20203135-7	2010	Thus, the no-observable-adverse-effect level (NOAEL) for NHE-water was estimated to be greater than 20 mL/kg/day under the conditions examined, demonstrating the consistency with the expected safety for a human with a body weight of 60 kg to drink the NHE-water up to at least 1.2 L/day.	Water	256-261	solute carrier family 9 member C1	Homo sapiens	57-60
20385797-6	2010	In contrast, studies in isolated, perfused S2 segments of proximal tubules showed that net transepithelial reabsorption of Na(+), Cl(-), and water was significantly decreased in Cldn2(-/-) mice and that there was an increase in paracellular shunt resistance without affecting the apical or basolateral membrane resistances.	Water	141-146	claudin 2	Mus musculus	178-183
20385840-5	2010	The proton-pumping pathway of bovine CcO comprises a hydrogen-bond network and a water channel which extend to the positive and negative side surfaces, respectively.	Water	81-86	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	37-40
20085283-3	2010	In THF-water and water the blocks are loosely segregated into P3TMAHT and PF2/6 rich domains, with PF2/6 dominating the aggregate interior.	Water	7-12	sperm associated antigen 17	Homo sapiens	74-79
20085283-3	2010	In THF-water and water the blocks are loosely segregated into P3TMAHT and PF2/6 rich domains, with PF2/6 dominating the aggregate interior.	Water	7-12	sperm associated antigen 17	Homo sapiens	99-104
20085283-3	2010	In THF-water and water the blocks are loosely segregated into P3TMAHT and PF2/6 rich domains, with PF2/6 dominating the aggregate interior.	Water	17-22	sperm associated antigen 17	Homo sapiens	74-79
20401158-3	2010	Fat-water-separated imaging in the heart by MRI is a sensitive means of detecting intramyocardial fat and characterizing fibrofatty infiltration.	Water	4-9	FAT atypical cadherin 1	Homo sapiens	0-3
20401158-3	2010	Fat-water-separated imaging in the heart by MRI is a sensitive means of detecting intramyocardial fat and characterizing fibrofatty infiltration.	Water	4-9	FAT atypical cadherin 1	Homo sapiens	98-101
20401158-5	2010	Multi-echo methods for fat and water separation provide a sensitive means of detecting small concentrations of fat with positive contrast and have a number of advantages over conventional chemical-shift fat suppression.	Water	31-36	FAT atypical cadherin 1	Homo sapiens	111-114
20401158-5	2010	Multi-echo methods for fat and water separation provide a sensitive means of detecting small concentrations of fat with positive contrast and have a number of advantages over conventional chemical-shift fat suppression.	Water	31-36	FAT atypical cadherin 1	Homo sapiens	111-114
20401158-6	2010	Furthermore, fat and water-separated imaging is useful in resolving artifacts that may arise due to the presence of fat.	Water	21-26	FAT atypical cadherin 1	Homo sapiens	116-119
20401158-7	2010	Examples of fat-water-separated imaging of the heart are presented for patients with ischemic and nonischemic cardiomyopathies, as well as general tissue classification.	Water	16-21	FAT atypical cadherin 1	Homo sapiens	12-15
20155951-5	2010	Lys111 and Lys112 are observed to bind to the N-terminal domain of chymosin displacing a conserved water molecule.	Water	99-104	chymosin	Bos taurus	67-75
20170102-6	2010	The calculated configurational entropy (S(C)) of the water molecules is found to be correlated with the self-diffusion coefficient of water in different region via Adam-Gibbs relation D = A exp(-B/TS(C)), and also with &lt;t(h)&gt;.	Water	53-58	solute carrier family 12 member 3	Homo sapiens	197-202
20170102-6	2010	The calculated configurational entropy (S(C)) of the water molecules is found to be correlated with the self-diffusion coefficient of water in different region via Adam-Gibbs relation D = A exp(-B/TS(C)), and also with &lt;t(h)&gt;.	Water	134-139	solute carrier family 12 member 3	Homo sapiens	197-202
20300630-9	2010	The conclusions are i) estrogen receptor genes are expressed during early development ii) altered expression of esr genes in response to ligand is dependent on the cellular context; iii) the estrogenic ligand 4-nonylphenol, a manufactured compound commonly found in sewage of water treatment plants, acts as an agonist of the estrogen receptor during development and has both agonist and antagonist properties in tissues of adult fish.	Water	276-281	MYC binding protein 2	Danio rerio	112-115
20141116-6	2010	Resemblance to computed representative conformations of CD26 in water was found for CD27 and CD28, with the similarity being better expressed for the former case.	Water	64-69	CD28 molecule	Homo sapiens	93-97
19997944-8	2010	In mice, the levels of plasma acylated ghrelin changed in proportion to the concentration of Rikkunshito in drinking water, and it was revealed by quantitative RT-PCR that the ghrelin mRNA expression level in the stomach was up-regulated.	Water	117-122	ghrelin	Mus musculus	176-183
20146235-3	2010	Saturation of the proton signal from protein and membrane phospholipid thus results in partial saturation of the water proton signal, allowing acquisition of an image including a portion of the water signal and the full fat signal.	Water	113-118	FAT atypical cadherin 1	Homo sapiens	220-223
20146235-4	2010	Subtraction of this image from the standard image, containing both water and fat signals, results in an image in which all fat signal is cancelled.	Water	67-72	FAT atypical cadherin 1	Homo sapiens	123-126
20146235-5	2010	This fat-free image is sensitive to magnetization transfer and to water density and relaxation time, providing the possibility of additional contrast.	Water	66-71	FAT atypical cadherin 1	Homo sapiens	5-8
20104849-4	2010	Correlations between milk water isotope ratios and purchase location tap water were significant.	Water	26-31	tracheal antimicrobial peptide	Bos taurus	69-72
20104849-4	2010	Correlations between milk water isotope ratios and purchase location tap water were significant.	Water	73-78	tracheal antimicrobial peptide	Bos taurus	69-72
20018876-1	2010	Aquaporin-1 (AQP1) water channels are expressed in the plasma membrane of dorsal root ganglion (DRG) neurons.	Water	19-24	aquaporin 1	Mus musculus	0-11
20018876-1	2010	Aquaporin-1 (AQP1) water channels are expressed in the plasma membrane of dorsal root ganglion (DRG) neurons.	Water	19-24	aquaporin 1	Mus musculus	13-17
20018876-2	2010	We found reduced osmotic water permeability in freshly isolated DRG neurons from AQP1(-/-) versus AQP1(+/+) mice.	Water	25-30	aquaporin 1	Mus musculus	81-85
20018876-2	2010	We found reduced osmotic water permeability in freshly isolated DRG neurons from AQP1(-/-) versus AQP1(+/+) mice.	Water	25-30	aquaporin 1	Mus musculus	98-102
19969073-8	2010	A kinetic model proposed earlier to rationalize results with Gpx1(-/-) erythrocytes also fits the data with Prdx2(-/-) cells and indicates that although Gpx1 and Prdx2 both participate in removing endogenous H(2)O(2), Prdx2 plays a larger role.	Water	208-213	peroxiredoxin 2	Mus musculus	162-167
19969073-8	2010	A kinetic model proposed earlier to rationalize results with Gpx1(-/-) erythrocytes also fits the data with Prdx2(-/-) cells and indicates that although Gpx1 and Prdx2 both participate in removing endogenous H(2)O(2), Prdx2 plays a larger role.	Water	208-213	peroxiredoxin 2	Mus musculus	162-167
20070118-1	2010	Cytochrome c oxidase (CcO), the terminal enzyme in the mitochondrial respiratory chain, catalyzes the four-electron reduction of dioxygen to water in a binuclear center comprised of a high-spin heme (heme a(3)) and a copper atom (Cu(B)) coordinated by three histidine residues.	Water	141-146	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
20070118-1	2010	Cytochrome c oxidase (CcO), the terminal enzyme in the mitochondrial respiratory chain, catalyzes the four-electron reduction of dioxygen to water in a binuclear center comprised of a high-spin heme (heme a(3)) and a copper atom (Cu(B)) coordinated by three histidine residues.	Water	141-146	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
19909794-2	2010	In the present study we investigated the effects of bilateral lesions of the CeA on the facilitation of water and 0.3 M NaCl intake produced by the blockade of serotonergic mechanisms or activation of alpha(2)-adrenoceptors with bilateral injections of methysergide or moxonidine, respectively, into the LPBN.	Water	104-109	carcinoembryonic antigen gene family 4	Rattus norvegicus	77-80
19909794-6	2010	Lesions of the CeA (5-18 days) abolished the increase in 0.3 M NaCl and water intake produced by bilateral injections of moxonidine (10.3+/-2.8 and 6.8+/-2.3 ml/2 h, respectively) and reduced the increase produced by methysergide (13.6+/-2.5 and 14.5+/-3.2 ml/2 h, respectively) into the LPBN.	Water	72-77	carcinoembryonic antigen gene family 4	Rattus norvegicus	15-18
19909794-7	2010	The present results show that the increase in water and 0.3 M NaCl intake produced by serotonergic blockade and alpha(2)-adrenergic activation in the LPBN depends on the integrity of the CeA, suggesting that facilitatory mechanisms present in the CeA are essential for the increase of water and hypertonic NaCl intake produced by the blockade of the inhibitory mechanisms of the LPBN.	Water	46-51	carcinoembryonic antigen gene family 4	Rattus norvegicus	187-190
19909794-7	2010	The present results show that the increase in water and 0.3 M NaCl intake produced by serotonergic blockade and alpha(2)-adrenergic activation in the LPBN depends on the integrity of the CeA, suggesting that facilitatory mechanisms present in the CeA are essential for the increase of water and hypertonic NaCl intake produced by the blockade of the inhibitory mechanisms of the LPBN.	Water	46-51	carcinoembryonic antigen gene family 4	Rattus norvegicus	247-250
19909794-7	2010	The present results show that the increase in water and 0.3 M NaCl intake produced by serotonergic blockade and alpha(2)-adrenergic activation in the LPBN depends on the integrity of the CeA, suggesting that facilitatory mechanisms present in the CeA are essential for the increase of water and hypertonic NaCl intake produced by the blockade of the inhibitory mechanisms of the LPBN.	Water	285-290	carcinoembryonic antigen gene family 4	Rattus norvegicus	187-190
19846107-7	2010	The elastic modulus, G" and complex viscosity,  eta*  of the I(1) phase increase with the dodecane concentration in the water/C(12)EO(6)/dodecane system, whereas, decreasing trend have been observed in the water/C(16)EO(6)/dodecane system.	Water	120-125	endothelin receptor type A	Homo sapiens	48-51
20023951-8	2010	The strong electrochromism of the complexes in the near-IR region has formed the basis of an optical window in which a thin film of 1(PF6)3 or 2(PF6)3 on a conductive glass surface can be reversibly and rapidly switched between redox states that alternate between strongly absorbing or near-transparent at 1100 nm, with--for 2(PF6)3--the switching being stable and reversible in water over thousands of cycles.	Water	379-384	sperm associated antigen 17	Homo sapiens	134-137
20023951-8	2010	The strong electrochromism of the complexes in the near-IR region has formed the basis of an optical window in which a thin film of 1(PF6)3 or 2(PF6)3 on a conductive glass surface can be reversibly and rapidly switched between redox states that alternate between strongly absorbing or near-transparent at 1100 nm, with--for 2(PF6)3--the switching being stable and reversible in water over thousands of cycles.	Water	379-384	sperm associated antigen 17	Homo sapiens	145-148
20023951-8	2010	The strong electrochromism of the complexes in the near-IR region has formed the basis of an optical window in which a thin film of 1(PF6)3 or 2(PF6)3 on a conductive glass surface can be reversibly and rapidly switched between redox states that alternate between strongly absorbing or near-transparent at 1100 nm, with--for 2(PF6)3--the switching being stable and reversible in water over thousands of cycles.	Water	379-384	sperm associated antigen 17	Homo sapiens	145-148
21079391-7	2010	The upregulation of de novo lipogenesis in the liver of the sucrose water-treated rats was demonstrated by an increased activity of enzymes, mRNA levels of lipogenic proteins, and nuclear levels of SREBP-1c and ChREBP.	Water	68-73	sterol regulatory element binding transcription factor 1	Rattus norvegicus	198-206
21079391-9	2010	CONCLUSION: The susceptibility of Wistar rats to sucrose water-induced MS is associated with the transactivation of SREBP-1c and ChREBP in the liver, and PTP-1B is involved in the upregulation of de novo lipogenesis in the liver and the pathology of systemic insulin resistance in rats with MS chronically induced by drinking sucrose water.	Water	57-62	sterol regulatory element binding transcription factor 1	Rattus norvegicus	116-124
21510484-2	2010	Several lines of evidence have demonstrated that the water channel aquaporin-1 (AQP1) corresponds to the ultrasmall pore predicted by the modelization of peritoneal transport.	Water	53-58	aquaporin 1	Mus musculus	80-84
21510484-3	2010	Proof-of-principle studies have shown that upregulation of the expression of AQP1 in peritoneal capillaries is reflected by increased water permeability and ultrafiltration, without affecting the osmotic gradient and the permeability for small solutes.	Water	134-139	aquaporin 1	Mus musculus	77-81
21510484-4	2010	Inversely, studies in Aqp1 mice have shown that haplo-insufficiency in AQP1 is reflected by significant attenuation of water transport.	Water	119-124	aquaporin 1	Mus musculus	71-75
20338098-4	2010	In the present study, we prepared a water-insoluble film by cross-linking pharmaceutical grade recombinant human serum albumin aiming to the clinical applications, and loaded the film with a synthetic antiplatelet drug, cilostazol.	Water	36-41	albumin	Mus musculus	113-126
20177566-6	2010	The investigation suggests that the phantom materials RW1 and Solid Water represent water-equivalent up to 20 cm from the source.	Water	84-89	transmembrane protein 131	Homo sapiens	54-57
19760484-0	2010	Centrally administered ghrelin potently inhibits water intake induced by angiotensin II and hypovolemia in rats.	Water	49-54	ghrelin and obestatin prepropeptide	Rattus norvegicus	23-30
19760484-2	2010	Recently, we showed that centrally administered ghrelin is a potent antidipsogenic hormone in 24-h water deprived rats.	Water	99-104	ghrelin and obestatin prepropeptide	Rattus norvegicus	48-55
19760484-3	2010	In this study, we examined the effect of intracerebroventricular (icv) injection of ghrelin on angiotensin II (AII)-induced water intake in rats.	Water	124-129	ghrelin and obestatin prepropeptide	Rattus norvegicus	84-91
19760484-5	2010	Water intake induced by the icv injection of AII or ip injection of PEG was significantly reduced after icv injection of ghrelin, although food intake was stimulated by the hormone.	Water	0-5	ghrelin and obestatin prepropeptide	Rattus norvegicus	121-128
20389002-0	2010	Electrochemical degradation of PAH compounds in process water: a kinetic study on model solutions and a proof of concept study on runoff water from harbour sediment purification.	Water	56-61	phenylalanine hydroxylase	Homo sapiens	31-34
20389002-0	2010	Electrochemical degradation of PAH compounds in process water: a kinetic study on model solutions and a proof of concept study on runoff water from harbour sediment purification.	Water	137-142	phenylalanine hydroxylase	Homo sapiens	31-34
19717236-2	2009	The optimum operating conditions for treatment of an aqueous solution containing 104, 105 and 103 mg/L amoxicillin, ampicillin, and cloxacillin, respectively was observed to be H(2)O(2)/COD molar ratio 1.5, H(2)O(2)/Fe(2+) molar ratio 20 and pH 3.	Water	177-182	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	186-189
19717236-2	2009	The optimum operating conditions for treatment of an aqueous solution containing 104, 105 and 103 mg/L amoxicillin, ampicillin, and cloxacillin, respectively was observed to be H(2)O(2)/COD molar ratio 1.5, H(2)O(2)/Fe(2+) molar ratio 20 and pH 3.	Water	207-212	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	186-189
19776169-1	2009	Aquaporin 1 (AQP1) is the major water channel in the renal proximal tubule (PT) and thin descending limb of Henle, but its regulation remains elusive.	Water	32-37	aquaporin 1	Rattus norvegicus	0-11
19776169-1	2009	Aquaporin 1 (AQP1) is the major water channel in the renal proximal tubule (PT) and thin descending limb of Henle, but its regulation remains elusive.	Water	32-37	aquaporin 1	Rattus norvegicus	13-17
19776169-10	2009	Thus ANG II increases AQP1 expression in vitro and in vivo via direct interaction with the AT(1) receptor, providing an important regulatory mechanism to link PT water reabsorption to body fluid homeostasis via the renin-angiotensin system.	Water	162-167	aquaporin 1	Rattus norvegicus	22-26
19812041-10	2009	Taken together, the results suggest the N170G TEM-1 enzyme hydrolyzes ampicillin efficiently because of substrate-assisted catalysis where the primary amine of the ampicillin R-group positions the hydrolytic water and allows for efficient deacylation.	Water	208-213	hypothetical protein	Escherichia coli	46-51
20158207-1	2010	Total organic halogen (TOX) is a collective parameter and a toxicity indicator for all the halogenated organic disinfection byproducts (DBPs) in a water sample.	Water	147-152	thymocyte selection associated high mobility group box	Homo sapiens	23-26
20172719-0	2010	Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway.	Water	15-20	toll-like receptor 2	Mus musculus	123-127
19891457-4	2010	The excess oxygen detected by XPS and the H(3)O(+) signal detected by ToF-SIMS for the SAMs with adsorbed peptides indicated that water molecules are associated with the adsorbed peptides, even under ultrahigh-vacuum conditions.	Water	130-135	methionine adenosyltransferase 1A	Homo sapiens	87-91
19875662-3	2010	METHODS: Filensin and CP49 were enriched by urea extraction of lens fiber cell homogenates after the water-soluble fraction was removed.	Water	101-106	beaded filament structural protein 1	Bos taurus	9-17
20084437-1	2010	The photoluminescence (PL) spectrum of water-soluble thiol-capped CdTe quantum dots (QDs) conjugated with Tat peptide in solution showed a remarkable redshift as compared to that of unconjugated QDs.	Water	39-44	tyrosine aminotransferase	Homo sapiens	106-109
20200365-2	2010	Several lines of evidence have demonstrated that the water channel aquaporin-1 (AQP1) corresponds to the ultrasmall pore predicted by the model of peritoneal transport.	Water	53-58	aquaporin 1	Mus musculus	67-78
20200365-2	2010	Several lines of evidence have demonstrated that the water channel aquaporin-1 (AQP1) corresponds to the ultrasmall pore predicted by the model of peritoneal transport.	Water	53-58	aquaporin 1	Mus musculus	80-84
20200365-3	2010	Proof-of-principle studies have shown that upregulation of the expression of AQP1 in peritoneal capillaries results in increased water permeability and ultrafiltration, without affecting the osmotic gradient or small solute permeability.	Water	129-134	aquaporin 1	Mus musculus	77-81
20200365-4	2010	Conversely, studies in Aqp1 mice have shown that haplo-insufficiency for AQP1 results in significant attenuation of water transport.	Water	116-121	aquaporin 1	Mus musculus	73-77
19955568-3	2010	Two-electrode voltage-clamp, fluorescence, and (45)Ca(2+) isotopic uptake determinations demonstrated voltage- and concentration-dependent, saturable, and substrate-inhibitable Ca(2+) transport in oocytes expressing GODZ cRNA but not in oocytes injected with water alone.	Water	259-264	zinc finger DHHC-type containing 3 S homeolog	Xenopus laevis	216-220
19768780-6	2010	Rheological study showed a very interesting melting behavior of PGN in water solution: heating PGN in water leads to two transitions, in the range of 8-12.5 degrees C and 25-60 degrees C, respectively.	Water	71-76	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	64-67
19768780-6	2010	Rheological study showed a very interesting melting behavior of PGN in water solution: heating PGN in water leads to two transitions, in the range of 8-12.5 degrees C and 25-60 degrees C, respectively.	Water	71-76	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	95-98
19768780-6	2010	Rheological study showed a very interesting melting behavior of PGN in water solution: heating PGN in water leads to two transitions, in the range of 8-12.5 degrees C and 25-60 degrees C, respectively.	Water	102-107	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	64-67
19768780-6	2010	Rheological study showed a very interesting melting behavior of PGN in water solution: heating PGN in water leads to two transitions, in the range of 8-12.5 degrees C and 25-60 degrees C, respectively.	Water	102-107	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	95-98
19768780-9	2010	The ability of PGN to undergo a conformation/viscosity transition in water upon heating is very valuable to immobilize cells or enzymes or therapeutic DNA/RNA, which makes PGN a potentially useful biomaterial.	Water	69-74	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	15-18
19768780-9	2010	The ability of PGN to undergo a conformation/viscosity transition in water upon heating is very valuable to immobilize cells or enzymes or therapeutic DNA/RNA, which makes PGN a potentially useful biomaterial.	Water	69-74	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	172-175
19796857-2	2010	Using an estimated D(5) flux to waste water of 11.6 mg cap(-1) d(-1), a 95.2% removal rate in Sewage Treatment Plants (STP) and a dilution factor of 10 results in modelled surface water concentrations that are up to an order of magnitude higher than concentrations observed downstream of STPs in two UK rivers.	Water	38-43	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	55-61
19796857-2	2010	Using an estimated D(5) flux to waste water of 11.6 mg cap(-1) d(-1), a 95.2% removal rate in Sewage Treatment Plants (STP) and a dilution factor of 10 results in modelled surface water concentrations that are up to an order of magnitude higher than concentrations observed downstream of STPs in two UK rivers.	Water	180-185	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	55-61
19796857-4	2010	Assuming the STP removal rate is reasonable, a waste water flux of 2.4 mg cap(-1) d(-1) is needed in order to obtain a reasonable match between predicted and observed in-river concentrations.	Water	53-58	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	74-80
20228419-4	2010	In water loaded animals, the mRNA levels of AGAT and CRT, and the activity of the CRT were greater in the cortex than in the medulla.	Water	3-8	glycine amidinotransferase	Rattus norvegicus	44-48
19000102-5	2010	GLU+FRU also attenuated the rise in heart rate that occurred in GLU and WATER and resulted in lower ratings of perceived exertion.	Water	72-77	zinc finger and BTB domain containing 22	Homo sapiens	4-7
20026307-6	2010	Furthermore, the C-terminus Viperin (214-361) which is insoluble in buffers but again can be solubilized in salt-free water appears to be only partially folded.	Water	118-123	radical S-adenosyl methionine domain containing 2	Homo sapiens	28-35
19640591-4	2010	Pigs immunized with a single dose of this vaccine candidate, formulated as a water-in oil emulsion, elicited an effective response against CSF as early as 7 days post-vaccination.	Water	77-82	colony stimulating factor 2	Sus scrofa	139-142
19624107-3	2009	Although both surfaces are hydrophilic, our study shows that hydration of potassium ions on the mica surface has a strong influence on the water structure and solvation force response of confined water.	Water	139-144	MHC class I polypeptide-related sequence A	Homo sapiens	96-100
19624107-3	2009	Although both surfaces are hydrophilic, our study shows that hydration of potassium ions on the mica surface has a strong influence on the water structure and solvation force response of confined water.	Water	196-201	MHC class I polypeptide-related sequence A	Homo sapiens	96-100
19780600-0	2009	Water vapor effect on the HNO3 yield in the HO2 + NO reaction: experimental and theoretical evidence.	Water	0-5	heme oxygenase 2	Homo sapiens	44-47
19647313-3	2009	Using tetrabutyl ammonium salt of HA (HA-TBA), water-insoluble anti-Flt1 peptide could be conjugated with HA in dimethyl sulfoxide (DMSO) by the amide bond formation between carboxyl groups of HA and N-terminal amine groups of GGNQWFI.	Water	47-52	Fms related receptor tyrosine kinase 1	Rattus norvegicus	68-72
19647313-9	2009	The water-soluble anti-Flt1 peptide-HA conjugate was thought to have a potential to be developed as anti-angiogenic therapeutics for the treatment of corneal neovascularization.	Water	4-9	Fms related receptor tyrosine kinase 1	Rattus norvegicus	23-27
19945674-25	2009	The specificity of the observed effect was confirmed, versus the water controls at the same dilution level by the absence of biological activity of inactive compounds such as histidine and 1-Methyl histamine and by the reversibility of this effect in the presence of a histamine receptor H2 antagonist.	Water	65-70	histamine receptor H2	Homo sapiens	269-290
19826230-9	2009	It is also envisioned that the MYB96-mediated signals are related with pathogen resistance response, which is also profoundly affected by water content in plant cells.	Water	138-143	myb domain protein 96	Arabidopsis thaliana	31-36
19549592-1	2009	Aldosterone, the endogenous ligand of the mineralocorticoid receptor (MR) in humans, is a steroid hormone that regulates salt and water homeostasis.	Water	130-135	nuclear receptor subfamily 3 group C member 2	Homo sapiens	42-68
19549592-1	2009	Aldosterone, the endogenous ligand of the mineralocorticoid receptor (MR) in humans, is a steroid hormone that regulates salt and water homeostasis.	Water	130-135	nuclear receptor subfamily 3 group C member 2	Homo sapiens	70-72
19655350-3	2009	Some important changes that occurred in the [(1)H,(13)C] HSQC NMR spectrum of cytochrome c treated with trans-[PtCl(2)(dma)(ma)] in water, after two days" incubation, most probably arose from direct platinum coordination to the protein side chain; this was proved conclusively by [(1)H,(1)H] NOESY NMR and [(1)H,(15)N] HSQC NMR measurements.	Water	132-137	LOC104968582	Bos taurus	78-90
19673520-3	2009	Here we provide the first demonstration that bovine submaxillary mucin and porcine gastric mucin accelerate the rate of fatty acid p-nitrophenol ester hydrolysis up to 337 times and a carbon-carbon bond-forming Diels-Alder reaction between N-propylmaleimide and anthracene up to 200 times relative to the rates of the reference processes, which were performed in water and chloroform, respectively.	Water	363-368	mucin 1, cell surface associated	Bos taurus	65-70
19673520-3	2009	Here we provide the first demonstration that bovine submaxillary mucin and porcine gastric mucin accelerate the rate of fatty acid p-nitrophenol ester hydrolysis up to 337 times and a carbon-carbon bond-forming Diels-Alder reaction between N-propylmaleimide and anthracene up to 200 times relative to the rates of the reference processes, which were performed in water and chloroform, respectively.	Water	363-368	mucin 1, cell surface associated	Bos taurus	91-96
19357362-3	2009	METHODS: EAU was induced and graded in C57BL/6J and CCR2(-/-) mice.	Water	9-12	chemokine (C-C motif) receptor 2	Mus musculus	52-56
19357362-10	2009	However, EAU induced in CCR2(-/-) mice was not reduced in severity, and neither was the percentage of macrophages in the retina.	Water	9-12	chemokine (C-C motif) receptor 2	Mus musculus	24-28
19478095-10	2009	Taken together, we suggest that mechanosensitive Cx30 hemichannels have an integral role in pressure natriuresis by releasing ATP into the tubular fluid, which inhibits salt and water reabsorption.	Water	178-183	gap junction protein, beta 6	Mus musculus	49-53
19638449-11	2009	These Cul3-silenced MCF7 cells are highly resistant to oxidative stress induced by H(2)O(2,) to the carcinogen benzo(a)pyrene, and to both Doxorubicin and Paclitaxel.	Water	83-88	cullin 3	Homo sapiens	6-10
19494047-4	2009	Time-resolved fluorescent immunoassay showed that arsenic suppressed hCG-induced synthesis of 11-ketotestosterone (11-KT) in testicular fragments incubated with 0.0001-100 microM arsenic and hCG for 18 h. A 0.1 microM (7 microg/l) dose of arsenic which is lower than the World Health Organization drinking water quality guideline of 10 microg/l most effectively reduced 11-KT production.	Water	306-311	chorionic gonadotropin subunit beta 5	Homo sapiens	69-72
19494047-4	2009	Time-resolved fluorescent immunoassay showed that arsenic suppressed hCG-induced synthesis of 11-ketotestosterone (11-KT) in testicular fragments incubated with 0.0001-100 microM arsenic and hCG for 18 h. A 0.1 microM (7 microg/l) dose of arsenic which is lower than the World Health Organization drinking water quality guideline of 10 microg/l most effectively reduced 11-KT production.	Water	306-311	chorionic gonadotropin subunit beta 5	Homo sapiens	191-194
19719315-5	2009	The CNT-Mica demonstrated an amphiphilic property for dispersing in water and toluene, but in an irreversible manner.	Water	68-73	MHC class I polypeptide-related sequence A	Homo sapiens	8-12
19457626-6	2009	Results further suggest the use of CST(1) to evaluate suitable combinations of salting-out agents and water-soluble polymers in this system.	Water	102-107	cystatin SN	Homo sapiens	35-41
19496603-0	2009	Peptide diffusion and self-assembly in ambient water nanofilm on mica surface.	Water	47-52	MHC class I polypeptide-related sequence A	Homo sapiens	65-69
19496603-2	2009	Here we report diffusion and self-assembly of peptides in ambient water nanofilms on mica, based on "drying microcontact printing" and ex situ atomic force microscopy imaging.	Water	66-71	MHC class I polypeptide-related sequence A	Homo sapiens	85-89
19496603-3	2009	We found that diffusion and self-assembly of several peptides in the water nanofilms on mica resulted in one-dimensional "epitaxial" nanofilaments.	Water	69-74	MHC class I polypeptide-related sequence A	Homo sapiens	88-92
19215235-0	2009	Reduced lung water transport rate associated with downregulation of aquaporin-1 and aquaporin-5 in aged mice.	Water	13-18	aquaporin 1	Mus musculus	68-79
19223077-3	2009	This study also showed that UV/Lamp2, which photolyzes water molecules and generates OH radicals, is more effective for PPCP removal than UV/lamp1.	Water	55-60	lysosomal associated membrane protein 1	Homo sapiens	141-146
19184379-4	2009	A hook type profile of rotational reorientation time (tau(r)) vs viscosity (eta) is obtained for all the solutes in dipolar aprotic mixture of dimethyl sulphoxide-water, with the rotational reorientation times being longer in organic solvent-rich zone, compared to the corresponding isoviscous point in water-rich zone due to strong hydrogen bonding.	Water	163-168	endothelin receptor type A	Homo sapiens	76-79
19184379-4	2009	A hook type profile of rotational reorientation time (tau(r)) vs viscosity (eta) is obtained for all the solutes in dipolar aprotic mixture of dimethyl sulphoxide-water, with the rotational reorientation times being longer in organic solvent-rich zone, compared to the corresponding isoviscous point in water-rich zone due to strong hydrogen bonding.	Water	303-308	endothelin receptor type A	Homo sapiens	76-79
19361929-4	2009	The PFDP/Cu and ODP/Cu SAMs were found to be very hydrophobic having water sessile drop static contact angles of more than 140 degrees , while DP/Cu and OP/Cu have contact angles of 119 degrees and 76 degrees , respectively.	Water	69-74	methionine adenosyltransferase 1A	Homo sapiens	23-27
19463562-8	2009	TbL2 was tested for the effect of some relevant interferents and the assay was applied to the determination of copper in tap water samples.	Water	125-130	transducin beta like 2	Homo sapiens	0-4
19954002-10	2009	(3) The respective PIP in the 4 groups was (33 +/- 2), (23 +/- 1), (24 +/- 2), (22 +/- 1) cm H2O; Cst was (1.1 +/- 0.3), (1.7 +/- 0.3), (1.5 +/- 0.1), (1.9 +/- 0.4) ml/cm H2O.	Water	93-96	prolactin-inducible protein homolog	Oryctolagus cuniculus	19-22
19309002-4	2009	The levels of vitellogenin (vg) mRNA and of the respective protein were significantly lowered in bees injected with bacteria or water only (injury).	Water	128-133	vitellogenin	Apis mellifera	14-26
19363093-0	2009	Phytochrome B enhances photosynthesis at the expense of water-use efficiency in Arabidopsis.	Water	56-61	phytochrome B	Arabidopsis thaliana	0-13
19363093-9	2009	In accordance to these observations, phyB reduced long-term water-use efficiency estimated by the analysis of isotopic discrimination against (13)CO(2).	Water	60-65	phytochrome B	Arabidopsis thaliana	37-41
19418079-1	2009	We prepared dense films of adsorbed brush-like macromolecules on mica substrate by transfer of compressed Langmuir monolayers from water subphase.	Water	131-136	MHC class I polypeptide-related sequence A	Homo sapiens	65-69
19230825-9	2009	Taken together, endothelial ET-1 over-expression and ETA receptor activation contributes to the increased oxidative stress, water accumulation and BBB breakdown after transient MCAO leading to more severe neurological deficit and increased infarct.	Water	124-129	endothelin receptor type A	Mus musculus	53-56
19179619-0	2009	Very high aquaporin-1 facilitated water permeability in mouse gallbladder.	Water	34-39	aquaporin 1	Mus musculus	10-21
19179619-9	2009	Our data indicate constitutively high water permeability in mouse gallbladder epithelium involving transcellular water transport through AQP1.	Water	38-43	aquaporin 1	Mus musculus	137-141
19179619-9	2009	Our data indicate constitutively high water permeability in mouse gallbladder epithelium involving transcellular water transport through AQP1.	Water	113-118	aquaporin 1	Mus musculus	137-141
19860799-9	2010	Interestingly, treatment with AM251 reduced (20%) TH gene expression in rats drinking only water.	Water	91-96	tyrosine hydroxylase	Rattus norvegicus	50-52
19944075-3	2010	Screening of loci, involved in renal water-salt balance regulation, highlighted the mineralocorticoid receptor gene NR3C2 as a potential target for several miRNAs.	Water	37-42	nuclear receptor subfamily 3 group C member 2	Homo sapiens	84-110
19944075-3	2010	Screening of loci, involved in renal water-salt balance regulation, highlighted the mineralocorticoid receptor gene NR3C2 as a potential target for several miRNAs.	Water	37-42	nuclear receptor subfamily 3 group C member 2	Homo sapiens	116-121
20396396-0	2010	B3LYP study on reduction mechanisms from O2 to H2O at the catalytic sites of fully reduced and mixed-valence bovine cytochrome c oxidases.	Water	47-50	LOC104968582	Bos taurus	116-128
20396396-1	2010	Reduction mechanisms of oxygen molecule to water molecules in the fully reduced (FR) and mixed-valence (MV) bovine cytochrome c oxidases (CcO) have been systematically examined based on the B3LYP calculations.	Water	43-48	LOC104968582	Bos taurus	115-127
19707795-2	2010	The signals of the sensing system are detected using a Handy-SPR and QCA922 when dropping 200 microL of Milli-Q water into the sensing cell.	Water	112-117	sepiapterin reductase	Homo sapiens	61-64
19854867-0	2010	Water adaptation strategy in anuran amphibians: molecular diversity of aquaporin.	Water	0-5	aquaporin	Xenopus laevis	71-80
19854867-4	2010	Aquaporin (AQP), a water channel protein, plays a fundamental role in these water absorption/reabsorption processes, which are regulated by antidiuretic hormone.	Water	19-24	aquaporin	Xenopus laevis	0-9
19854867-4	2010	Aquaporin (AQP), a water channel protein, plays a fundamental role in these water absorption/reabsorption processes, which are regulated by antidiuretic hormone.	Water	19-24	aquaporin-x3	Xenopus laevis	11-14
19748503-13	2010	Thus, the development of diabetes increases neuroretinal apoptosis, and this coincides with an altered expression pattern of GFAP and water-selective channels AQPs 1 and 4 in SDT rats.	Water	134-139	aquaporin 1	Rattus norvegicus	159-171
19766630-2	2010	Furthermore, EAU symptoms are ameliorated in OPN knockout mice or in B6 mice treated with anti-OPN antibody (M5).	Water	13-16	secreted phosphoprotein 1	Mus musculus	45-48
19766630-2	2010	Furthermore, EAU symptoms are ameliorated in OPN knockout mice or in B6 mice treated with anti-OPN antibody (M5).	Water	13-16	secreted phosphoprotein 1	Mus musculus	95-98
19766630-5	2010	EAU was induced in B6 mice by immunization with human interphotoreceptor retinoid-binding protein (hIRBP) peptide sequence 1-20.	Water	0-3	retinol binding protein 3	Homo sapiens	54-97
19766630-5	2010	EAU was induced in B6 mice by immunization with human interphotoreceptor retinoid-binding protein (hIRBP) peptide sequence 1-20.	Water	0-3	retinol binding protein 3	Homo sapiens	99-104
20008963-3	2010	Herein, we investigate the anti-ischemic properties of a water-soluble beta-d-fructan (MDG-1) from Ophiopogon japonicus, and assess the cytoprotective and proangiogenic effects of MDG-1.	Water	57-62	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	87-92
20008963-3	2010	Herein, we investigate the anti-ischemic properties of a water-soluble beta-d-fructan (MDG-1) from Ophiopogon japonicus, and assess the cytoprotective and proangiogenic effects of MDG-1.	Water	57-62	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	180-185
20482991-4	2010	Covalent binding of HMW PEI by a two-step-activation method produced the highest amino group density and the lowest water contact angle.	Water	116-121	cilia and flagella associated protein 97	Homo sapiens	20-23
21462714-2	2010	Chemical analysis of water from Binlamdoune River of the medina of Fez was conducted and the results revealed the presence of toxic elements from tanneries and other industrial activities, which strongly affected water quality.	Water	21-26	FEZ family zinc finger 1	Homo sapiens	67-70
19845481-2	2010	Silk fibroin was extracted from Bombyx mori cocoon, purified, concentrated in polyethylene glycol solution and diluted to 3 wt% with distilled water.	Water	143-148	fibroin light chain	Bombyx mori	5-12
22966257-1	2010	The present study investigated whether a water-soluble extract from the culture medium of Ganoderma lucidum (Reishi) mycelia (MAK) is able to protect the small intestine against damage induced by anti-cancer drugs.	Water	41-46	male germ cell-associated kinase	Mus musculus	126-129
21186640-1	2010	In experiment on rats in the immunodeficiency the use of recombinant epidermal growth factor was substantiated that let to speed up reparative regeneration at concentration 500 ppb/l drinking water.	Water	192-197	epidermal growth factor like 1	Rattus norvegicus	69-92
19923889-10	2009	Therefore, this review will focus on H(2)O(2) modulating cell signaling via Prdxs by discussing: (1) the activity of Prdxs towards H(2)O(2); (2) sub cellular localization and availability of other peroxidases, such as catalase or glutathione peroxidases; (3) the availability of Prdxs reducing systems, such as thioredoxin and sulfiredoxin and lastly, (4) Prdx1 interacting signaling molecules.	Water	37-42	sulfiredoxin 1	Homo sapiens	327-339
19801182-7	2009	We demonstrate that the swelling of PEM in H(2)O and D(2)O vapours is similar.	Water	43-48	mucin 1, cell surface associated	Homo sapiens	36-39
19801182-13	2009	We showed that the amount of sorbed water depends on the nature of the last layer which builds the PEM thus confirming the "odd-even effect" already shown in the literature.	Water	36-41	mucin 1, cell surface associated	Homo sapiens	99-102
19808921-6	2009	GLP-1 peak and area under the curve (AUC) were significantly higher with diet soda (AUC 24.0 +/- 15.2 pmol/l per 180 min) versus carbonated water (AUC 16.2 +/- 9.0 pmol/l per 180 min; P = 0.003).	Water	140-145	glucagon like peptide 1 receptor	Homo sapiens	0-5
19816502-0	2009	Epigenetics, essential hypertension and renin-angiotensin system upregulation in the offspring of water-deprived pregnant rats.	Water	98-103	renin	Rattus norvegicus	40-45
19827911-4	2009	Three levels (PAL 1, PAL 2, and PAL 3), distinguished by severity of toxic effects, are developed for 24-hour, 30-day, 90-day, and 2-year durations of potential drinking water and inhalation exposures for the general public.	Water	170-175	SHC binding and spindle associated 1	Homo sapiens	14-17
19957991-0	2009	Infiltration of water molecules into the oseltamivir-binding site of H274Y neuraminidase mutant causes resistance to oseltamivir.	Water	16-21	neuraminidase 1	Homo sapiens	75-88
19395026-0	2009	OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus.	Water	0-4	immunoglobulin heavy locus	Homo sapiens	50-53
19919143-6	2009	Trps 68, 156 in human gammaD- and Trp72 in human gammaS-Crystallin are buried, but water can reach amide oxygen and ring HE1 atoms through narrow channels.	Water	83-88	NPC intracellular cholesterol transporter 2	Homo sapiens	121-124
19847037-1	2009	Nafion was used for the first time to aid in preparing stable graphene dispersions in mixed water/ethanol (1:1) solvents via the reduction of graphite oxide using hydrazine.	Water	92-97	activation induced cytidine deaminase	Homo sapiens	38-41
19703534-3	2009	MATERIALS AND METHODS: The cell viability, anti-oxidative activity, and anti-apoptotic activity of a water extract of URH (URE) were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide, reactive oxygen species (ROS), total glutathione (GSH), and caspase-3 assays in PC12 cells stressed by 6-OHDA.	Water	101-106	caspase 3	Rattus norvegicus	271-280
19811924-0	2009	Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury.	Water	24-29	elastase, neutrophil expressed	Homo sapiens	58-77
19705110-4	2009	The data obtained suggested that the low water-soluble, non-polar pesticide rotenone resulted preferentially adsorbed onto HAs by hydrophobic interaction, that was the prevailing mechanism in the order HA S1 &gt; HA S2 &gt;&gt;&gt; HA SR, whereas hydrogen bonds resulted predominant in the opposite order.	Water	41-46	hyaluronan synthase 2	Homo sapiens	213-218
19388090-2	2009	RGDS peptides were further immobilized under the catalyzation of water soluble carbodiimide (EDAC).	Water	65-70	ral guanine nucleotide dissociation stimulator	Homo sapiens	0-4
20201435-1	2009	We have demonstrated a time-resolved luminescence (TRL) assay for the sensitive and selective detection of thyroglobulin (Tg), a thyroid cancer marker, in homogeneous solution using water-soluble alpha-D-mannose-conjugated Au nanodots (Man-Au NDs).	Water	182-187	thyroglobulin	Homo sapiens	107-120
19801433-9	2009	Selective gene knockdown using morpholino antisense oligonucleotides demonstrated a significant role for SLC26A3 in Cl- uptake in larval fish raised in control water and roles for A3, A4 and A6c in fish raised in water with low [Cl-].	Water	160-165	solute carrier family 26 member 3	Danio rerio	105-112
19428179-2	2009	This THM enhancement occurs for model solutions as well as for natural water (Turia river).	Water	71-76	THM	Homo sapiens	5-8
19772357-1	2009	A direct white-light metal-organic framework (MOF), [AgL](n) x nH(2)O (1, L = 4-cyanobenzoate), obtained by the reaction of deprotonated 4-cyanobenzoic acid and AgNO(3) in water, was found to exhibit tunable yellow-to-white photoluminescence by variation of excitation light.	Water	172-177	lysine acetyltransferase 8	Homo sapiens	21-51
19345005-1	2009	Potassium permanganate, widely used in water treatment, has shown its applicability to reduce PAH contamination in groundwater and soils.	Water	39-44	phenylalanine hydroxylase	Homo sapiens	94-97
19700677-2	2009	Normally, such changes are limited by the amount of water entrapped in the cheese at the time of block formation but for brined cheeses such as feta cheese brine acts as a reservoir of additional water.	Water	196-201	ATPase phospholipid transporting 8B5, pseudogene	Homo sapiens	144-148
19514753-3	2009	It was clarified that the interaction between carbonyl/carboxylic acid groups of PLLA and the HAp nanoparticles at the CH(2)Cl(2)-water interface played a crucial role to prepare the stable Pickering-type emulsion.	Water	130-135	reticulon 3	Homo sapiens	94-97
19539491-4	2009	Water stress (PEG treatment) induced beta-amylase was associated with H(2)O(2) concentration but not with ABA concentration.	Water	0-5	1,4-alpha-D-glucan maltohydrolase	Hordeum vulgare	37-49
19618900-1	2009	Cytidine deaminase (CDA) catalyzes the deamination of cytidine via a hydrated transition-state intermediate that results from the nucleophilic attack of zinc-bound water at the active site.	Water	164-169	cytidine deaminase	Homo sapiens	0-18
19618900-1	2009	Cytidine deaminase (CDA) catalyzes the deamination of cytidine via a hydrated transition-state intermediate that results from the nucleophilic attack of zinc-bound water at the active site.	Water	164-169	cytidine deaminase	Homo sapiens	20-23
19274732-1	2009	B-type natriuretic peptide (BNP) is a naturally secreted regulatory hormone that influences blood pressure and vascular water retention in human physiology.	Water	120-125	natriuretic peptide B	Homo sapiens	0-26
19274732-1	2009	B-type natriuretic peptide (BNP) is a naturally secreted regulatory hormone that influences blood pressure and vascular water retention in human physiology.	Water	120-125	natriuretic peptide B	Homo sapiens	28-31
19205024-5	2009	In this study, we used replica exchange molecular dynamics (REMD) simulations to model S1M1 and S2M3 connecting peptides of the GluR2 receptor in two implicit solvents, water and interfacial water/lipid medium characterized by lower polarity.	Water	191-196	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	128-133
19581575-4	2009	Expulsion of water, resulting in the formation of a dry interface between 2 adjacent sheets of the Sup35 fibril, occurs in 2 stages.	Water	13-18	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	99-104
20161635-0	2009	First Multi-gram Preparation SCP-123, A Novel Water Soluble Analgesic.	Water	46-51	urocortin 3	Homo sapiens	29-32
19518079-1	2009	New water-soluble cationic meso-tetraarylporphyrins (TArP, Ar = 4-C(6)H(4)) and some metal derivatives have been synthesized and characterized.	Water	4-9	uncharacterized protein LOC100335800	Bos taurus	53-57
19564604-3	2009	Central ghrelin administration (to brain ventricles or to tegmental areas involved in reward) increased alcohol intake in a 2-bottle (alcohol/water) free choice limited access paradigm in mice.	Water	142-147	ghrelin	Mus musculus	8-15
19401454-9	2009	Treatment with H(2)O(2) increased the abundance of NOX2, HSF1, and PAI-1 in EC.	Water	15-20	heat shock transcription factor 1	Homo sapiens	57-61
21783979-4	2009	Moreover, hopeahainol A could mitigate intracellular accumulation of reactive oxygen species (ROS) and Ca(2+), the loss of mitochondrial membrane potential (MMP), and the increase of caspase-3, -8 and -9 activities induced by H(2)O(2).	Water	226-231	caspase 3	Rattus norvegicus	183-203
19423692-7	2009	In co-expression experiments, P2R activation decreased membrane AQP2 and AQP2-mediated water permeability in Xenopus oocytes expressing P2X(2), P2Y(2,) or P2Y(4) receptors, but not in oocytes expressing other P2R subtypes.	Water	87-92	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	136-142
19423692-8	2009	In summary, these data suggest that AQP2-mediated water transport is downregulated not only by basolateral nucleotides, mediated by P2Y(2) receptors, but also by luminal nucleotides, mediated by P2X(2) and/or P2Y(4) receptors.	Water	50-55	purinergic receptor P2X, ligand-gated ion channel, 2	Mus musculus	195-201
19403703-1	2009	Aquaporin (AQP) water channels, essential for fluid homeostasis, are expressed in perivascular brain end-feet regions of astroglia (AQP4) and in choroid plexus (AQP1).	Water	16-21	aquaporin 1	Rattus norvegicus	161-165
19578709-6	2009	Ang-(1-7) has been reported to induce either natriuresis/diuresis or sodium and water retention, via modulation of sodium transporters in the proximal tubule and loop of Henle, and collecting duct water transport.	Water	80-85	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	0-8
19578709-6	2009	Ang-(1-7) has been reported to induce either natriuresis/diuresis or sodium and water retention, via modulation of sodium transporters in the proximal tubule and loop of Henle, and collecting duct water transport.	Water	197-202	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	0-8
19404626-7	2009	Ruthenium red, a water soluble polycationic dye, was found to block the pore of the capsaicin-operated cation channel TRPV1 thus interfering with all polymodal ways of TRPV1 activation.	Water	17-22	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	118-123
19365033-4	2009	Then EAU was induced by immunization with human interphotoreceptor retinoid-binding protein (hIRBP) peptide 1-20, followed by intravenous injection of hIRBP peptide-pulsed regulatory DCs.	Water	5-8	retinol binding protein 3	Homo sapiens	48-91
19365033-4	2009	Then EAU was induced by immunization with human interphotoreceptor retinoid-binding protein (hIRBP) peptide 1-20, followed by intravenous injection of hIRBP peptide-pulsed regulatory DCs.	Water	5-8	retinol binding protein 3	Homo sapiens	93-98
19085041-6	2009	Abnormal water metabolism was shown with AQP1, 2, 3, 4, 5 null mice, especially with AQP2 null mice: fatal at neonate due to diabetes insipidus.	Water	9-14	aquaporin 1	Mus musculus	41-45
24650158-2	2014	Simulations of an isolated water molecule embedded in 1-butyl-3-methyl imidazolium hexafluorophosphate, [bmim][PF6], were performed to shed insight into the nature of these coupled water-ion dynamics.	Water	27-32	sperm associated antigen 17	Homo sapiens	111-114
19258016-2	2009	A mutation in the EIN3 gene delayed the water-stress related increase in alpha-tocopherol and caused a reduction in the levels of this antioxidant by ca.	Water	40-45	Ethylene insensitive 3 family protein	Arabidopsis thaliana	18-22
19366375-5	2009	Functional analysis in Xenopus oocytes microinjected with the cRNA of these AQPs revealed that the AQP-Bom1 mRNA encodes a water-specific aquaporin, likely involved in the water retrieval function of the hindgut, while the AQP-Bom2 mRNA encodes an aquaglyceroporin, increasing glycerol and urea uptake.	Water	123-128	aquaporin	Xenopus laevis	138-147
19366375-5	2009	Functional analysis in Xenopus oocytes microinjected with the cRNA of these AQPs revealed that the AQP-Bom1 mRNA encodes a water-specific aquaporin, likely involved in the water retrieval function of the hindgut, while the AQP-Bom2 mRNA encodes an aquaglyceroporin, increasing glycerol and urea uptake.	Water	172-177	aquaporin	Xenopus laevis	138-147
24650158-2	2014	Simulations of an isolated water molecule embedded in 1-butyl-3-methyl imidazolium hexafluorophosphate, [bmim][PF6], were performed to shed insight into the nature of these coupled water-ion dynamics.	Water	181-186	sperm associated antigen 17	Homo sapiens	111-114
19317426-8	2009	This also defines the proximal (presumably water) channel that opens in CYP46A1 upon substrate binding.	Water	43-48	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	72-79
19289047-4	2009	We report on the structure and morphology of Cer-1-P in monomolecular layers at the air/water solution interface in the absence and presence of Ca(2+) using diverse biophysical techniques, including synchrotron x-ray reflectivity and grazing angle diffraction, to gain insight into the role and function of Cer-1-P in biomembranes.	Water	88-93	cerberus 1, DAN family BMP antagonist	Homo sapiens	45-50
24829503-5	2014	Significant increases in nesfatin-1/NucB2 mRNA levels, ~2- to 3-fold compared with control, were observed in the SFO, SON, and PVN following water deprivation for 48 h, consumption of 2% NaCl hypertonic saline in drinking water for 5 days, and polyethylene glycol-induced hypovolemia.	Water	141-146	nucleobindin 2	Rattus norvegicus	25-35
19289047-5	2009	We show that relatively small changes in pH and the presence of monovalent cations dramatically affect the behavior of Cer-1-P. On pure water Cer-1-P forms a solid monolayer despite the negative charge of the phosphomonoester headgroup.	Water	136-141	cerberus 1, DAN family BMP antagonist	Homo sapiens	119-124
19289047-5	2009	We show that relatively small changes in pH and the presence of monovalent cations dramatically affect the behavior of Cer-1-P. On pure water Cer-1-P forms a solid monolayer despite the negative charge of the phosphomonoester headgroup.	Water	136-141	cerberus 1, DAN family BMP antagonist	Homo sapiens	142-147
19385676-9	2009	In water, dB(e)/dc is linear with T/eta with zero intercept as required by the SE; however, with slope a factor of 0.73 smaller.	Water	3-8	endothelin receptor type A	Homo sapiens	36-39
24829503-5	2014	Significant increases in nesfatin-1/NucB2 mRNA levels, ~2- to 3-fold compared with control, were observed in the SFO, SON, and PVN following water deprivation for 48 h, consumption of 2% NaCl hypertonic saline in drinking water for 5 days, and polyethylene glycol-induced hypovolemia.	Water	141-146	nucleobindin 2	Rattus norvegicus	36-41
24829503-5	2014	Significant increases in nesfatin-1/NucB2 mRNA levels, ~2- to 3-fold compared with control, were observed in the SFO, SON, and PVN following water deprivation for 48 h, consumption of 2% NaCl hypertonic saline in drinking water for 5 days, and polyethylene glycol-induced hypovolemia.	Water	222-227	nucleobindin 2	Rattus norvegicus	25-35
19601870-4	2009	The analysis of P450-catalyzed reaction rates is elaborated to encompass a treatment of metabolic clearance, and satisfactory correlations are obtained with literature values for both intrinsic clearance and whole body clearance in terms of compound lipophilicity derived from log P data, where P is the octanol/water partition coefficient.	Water	312-317	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	16-20
19120059-11	2009	Combined IL-15 and IL-15R alpha treatment decreased apoptosis of NK cells from alcohol-consuming mice to levels similar to untreated water-drinking mice and greatly increased the percentage and number of NK cells in both the spleen and BM.	Water	133-138	interleukin 15 receptor, alpha chain	Mus musculus	19-31
24829503-5	2014	Significant increases in nesfatin-1/NucB2 mRNA levels, ~2- to 3-fold compared with control, were observed in the SFO, SON, and PVN following water deprivation for 48 h, consumption of 2% NaCl hypertonic saline in drinking water for 5 days, and polyethylene glycol-induced hypovolemia.	Water	222-227	nucleobindin 2	Rattus norvegicus	36-41
24829503-6	2014	In addition, nesfatin-1/NucB2 expression was increased in response to water deprivation in a time-dependent manner.	Water	70-75	nucleobindin 2	Rattus norvegicus	13-23
19408429-12	2009	The surface water tests showed three sites were positive for Cryptosporidium spp.	Water	12-17	histocompatibility minor 13	Homo sapiens	77-80
24829503-6	2014	In addition, nesfatin-1/NucB2 expression was increased in response to water deprivation in a time-dependent manner.	Water	70-75	nucleobindin 2	Rattus norvegicus	24-29
24829503-9	2014	Moreover, intracerebroventricular administration of nesfatin-1/NucB2-neutralizing antibody after 48 h of water deprivation resulted in a significant increase in food intake compared with administration of vehicle alone.	Water	105-110	nucleobindin 2	Rattus norvegicus	52-62
24829503-9	2014	Moreover, intracerebroventricular administration of nesfatin-1/NucB2-neutralizing antibody after 48 h of water deprivation resulted in a significant increase in food intake compared with administration of vehicle alone.	Water	105-110	nucleobindin 2	Rattus norvegicus	63-68
24939723-2	2014	A new triazolyl phosphonate metal-organic framework (MOF) [La3L4(H2O)6]Cl x H2O (1, L(2-) = 4-(4H-1,2,4-triazol-4-yl)phenyl phosphonate) with highly hydrophilic 1D channels was synthesized hydrothermally.	Water	65-68	lysine acetyltransferase 8	Homo sapiens	28-57
19288015-8	2009	Indomethacin in drinking water reversed the clone 20 induced decrease in body and fat weight and food intake, and simultaneously negated the clone 20 induced increase of SSAT expressions and decrease of ACC and malonyl-CoA amounts.	Water	25-30	spermidine/spermine N1-acetyl transferase 1	Mus musculus	170-174
18661534-5	2009	Phenacetin displays two peaks at 60% ethanol in ethyl acetate (23.30 MPa(1/2)) and 90% ethanol in water (delta(1) = 28.64 MPa(1/2)).	Water	98-103	guanylate binding protein 4	Homo sapiens	122-131
24854623-1	2014	1-Methylimidazole (1-MIM) and 2-methylimidazole (2-MIM) are miscible in water and imidazolium based ionic liquids (ILs), and can coordinate with soft metal ions.	Water	72-77	MTSS I-BAR domain containing 1	Homo sapiens	21-24
19097243-4	2009	In this work, two fat-water separation algorithms are developed for the concentric rings.	Water	22-27	FAT atypical cadherin 1	Homo sapiens	18-21
19097243-5	2009	A retracing design is used to sample rings near the center of k-space through multiple revolutions to characterize the fat-water phase evolution difference at multiple time points.	Water	123-128	FAT atypical cadherin 1	Homo sapiens	119-122
19097243-8	2009	The spectral information can be used to assess field variation and perform robust fat-water separation.	Water	86-91	FAT atypical cadherin 1	Homo sapiens	82-85
19228016-5	2009	Upon proteolytic cleavage of the peptide by MMP-2, the PEG chain is detached from the CA, which becomes less water soluble.	Water	109-114	matrix metallopeptidase 2	Homo sapiens	44-49
24854623-1	2014	1-Methylimidazole (1-MIM) and 2-methylimidazole (2-MIM) are miscible in water and imidazolium based ionic liquids (ILs), and can coordinate with soft metal ions.	Water	72-77	MTSS I-BAR domain containing 1	Homo sapiens	51-54
19366470-6	2009	Recent studies of water transport and the spatial buffering of K+ through glial cells have highlighted the involvement of both AQP4 and Kir channels in regulating the extracellular environment in the brain and retina.	Water	18-23	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	136-139
25050039-11	2014	Naked Neck chickens had better FCR at the 40% of ad libitum water intake level than Ovambo chickens.	Water	60-65	FCR	Gallus gallus	31-34
19170610-10	2009	Stopped-flow CD revealed that the time of unfolding of mutant StAR was 0.017 s. In contrast, the wild-type StAR protein is unfolded in 16.3 s. In summary, these results demonstrate that wild-type StAR adopts a very flexible form due to the accommodation of more water molecules, while mutant StAR is generated by an alternate folding pathway making it inactive.	Water	262-267	steroidogenic acute regulatory protein	Homo sapiens	62-66
19170610-10	2009	Stopped-flow CD revealed that the time of unfolding of mutant StAR was 0.017 s. In contrast, the wild-type StAR protein is unfolded in 16.3 s. In summary, these results demonstrate that wild-type StAR adopts a very flexible form due to the accommodation of more water molecules, while mutant StAR is generated by an alternate folding pathway making it inactive.	Water	262-267	steroidogenic acute regulatory protein	Homo sapiens	107-111
19170610-10	2009	Stopped-flow CD revealed that the time of unfolding of mutant StAR was 0.017 s. In contrast, the wild-type StAR protein is unfolded in 16.3 s. In summary, these results demonstrate that wild-type StAR adopts a very flexible form due to the accommodation of more water molecules, while mutant StAR is generated by an alternate folding pathway making it inactive.	Water	262-267	steroidogenic acute regulatory protein	Homo sapiens	107-111
19170610-10	2009	Stopped-flow CD revealed that the time of unfolding of mutant StAR was 0.017 s. In contrast, the wild-type StAR protein is unfolded in 16.3 s. In summary, these results demonstrate that wild-type StAR adopts a very flexible form due to the accommodation of more water molecules, while mutant StAR is generated by an alternate folding pathway making it inactive.	Water	262-267	steroidogenic acute regulatory protein	Homo sapiens	107-111
19296710-0	2009	Interaction of water highly diluted in 1-alkyl-3-methyl imidazolium ionic liquids with the PF6(-) and BF4(-) anions.	Water	15-20	sperm associated antigen 17	Homo sapiens	91-94
19199480-3	2009	Water-solubilizing groups could be installed conveniently at either the C-2 or C-3 position of the imidazo[1,2-b]thiazole ring.	Water	0-5	complement component 3	Mus musculus	79-82
24837571-5	2014	We determined that extinction induced synaptophysin expression and down-regulated the GluA1:GluA2 ratio throughout the fear network in water- and fluoxetine-treated mice, suggesting a common fluoxetine-independent mechanism for increased synaptic transmission and re-arrangement of AMPA-receptors by extinction training.	Water	135-140	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	86-91
19144536-0	2009	A T-DNA insertion mutant of AtHMA1 gene encoding a Cu transporting ATPase in Arabidopsis thaliana has a defect in the water-water cycle of photosynthesis.	Water	118-123	heavy metal atpase 1	Arabidopsis thaliana	28-34
19144536-0	2009	A T-DNA insertion mutant of AtHMA1 gene encoding a Cu transporting ATPase in Arabidopsis thaliana has a defect in the water-water cycle of photosynthesis.	Water	124-129	heavy metal atpase 1	Arabidopsis thaliana	28-34
19144536-2	2009	Here we showed that the water-water cycle is impaired in the T-DNA insertion mutant of AtHMA1 gene encoding a Cu transporting ATPase in chloroplasts.	Water	24-29	heavy metal atpase 1	Arabidopsis thaliana	87-93
19144536-2	2009	Here we showed that the water-water cycle is impaired in the T-DNA insertion mutant of AtHMA1 gene encoding a Cu transporting ATPase in chloroplasts.	Water	30-35	heavy metal atpase 1	Arabidopsis thaliana	87-93
19144536-7	2009	Based on the NPQ induction under 0% oxygen condition, we conclude that the water-water cycle is impaired in hma1, presumably due to the decreased level of Cu/Zn SOD in the mutant.	Water	75-80	heavy metal atpase 1	Arabidopsis thaliana	108-112
19144536-7	2009	Based on the NPQ induction under 0% oxygen condition, we conclude that the water-water cycle is impaired in hma1, presumably due to the decreased level of Cu/Zn SOD in the mutant.	Water	81-86	heavy metal atpase 1	Arabidopsis thaliana	108-112
19513415-4	2009	Water deprivation for 11 h was followed by a 4-fold increase in Cox-2 gene expression in ISIAH rats.	Water	0-5	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	64-69
24837571-5	2014	We determined that extinction induced synaptophysin expression and down-regulated the GluA1:GluA2 ratio throughout the fear network in water- and fluoxetine-treated mice, suggesting a common fluoxetine-independent mechanism for increased synaptic transmission and re-arrangement of AMPA-receptors by extinction training.	Water	135-140	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	92-97
25265850-6	2014	Transcript levels of the AOX1 gene began to increase in response to water stress before those of PTOX suggesting that alternative respiration may react faster to water stress than chlororespiration.	Water	68-73	ubiquinol oxidase 1, mitochondrial	Glycine max	25-29
18936104-0	2009	Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat.	Water	119-124	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	33-38
18676058-1	2009	The boundary between preferential flow and Richards-type flow is a priori set at a volumetric soil water content theta* at which soil water diffusivity D (theta*) = eta (= 10(-6) m(2) s(-1)), where eta is the kinematic viscosity.	Water	134-139	endothelin receptor type A	Homo sapiens	115-118
19193235-11	2009	Nospamin (49.5%) and Gripe water (43.0%) were the two frequently prescribed and self-medicated medicines for infants with colic.	Water	27-32	Ral GTPase activating protein catalytic subunit alpha 1	Homo sapiens	21-26
25265850-6	2014	Transcript levels of the AOX1 gene began to increase in response to water stress before those of PTOX suggesting that alternative respiration may react faster to water stress than chlororespiration.	Water	162-167	ubiquinol oxidase 1, mitochondrial	Glycine max	25-29
25168975-5	2014	On the whole beach sand and water isolates demonstrated clearly different prevalence levels of vancomycin resistance, biofilm formation, esp and gel gene carriage.	Water	28-33	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	137-140
19026608-0	2009	K+ binding in the G-loop and water cavity facilitates Ba2+ movement in the Kir2.1 channel.	Water	29-34	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	75-81
19047197-2	2009	Application of diC8-PIP(2), a water soluble form of PIP(2), to quiescent inside-out patches evoked single channel currents with a unitary conductance of 1.9 pS.	Water	30-35	prolactin-inducible protein homolog	Oryctolagus cuniculus	20-23
19047197-2	2009	Application of diC8-PIP(2), a water soluble form of PIP(2), to quiescent inside-out patches evoked single channel currents with a unitary conductance of 1.9 pS.	Water	30-35	prolactin-inducible protein homolog	Oryctolagus cuniculus	52-55
24849348-0	2014	Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.	Water	82-87	regulator of microtubule dynamics 3	Mus musculus	8-11
19010334-2	2009	An important enzyme in this process is superoxide dismutase, Sod1, which converts superoxide radicals into water and hydrogen peroxide.	Water	107-112	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	61-65
19032361-2	2009	We previously reported that oral administration of a water-soluble extract prepared from Actinidia arguta, code-named PG102, could modulate the level of Th1 and Th2 cytokines and suppress the production of immunoglobulin E (IgE) in the ovalbumin (OVA)-immunized murine model as well as in the in vitro cell culture system, and furthermore could significantly improve dermatitis conditions in the NC/Nga murine model.	Water	53-58	interphotoreceptor matrix proteoglycan 2	Mus musculus	118-123
19256653-8	2009	True atomic-resolution imaging of mica in water is demonstrated using the developed deflection sensor and the photothermal excitation system.	Water	42-47	MHC class I polypeptide-related sequence A	Homo sapiens	34-38
24824358-0	2014	Deep sea water prevents balloon angioplasty-induced hyperplasia through MMP-2: an in vitro and in vivo study.	Water	9-14	matrix metallopeptidase 2	Rattus norvegicus	72-77
19101552-1	2009	The deleterious effects of oxidants on proteins may be modified by overexpression of uncoupling protein 3 (UCP3) in skeletal muscle cells exposed to hyperoxia or H(2)O(2).	Water	162-167	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	85-105
19101552-1	2009	The deleterious effects of oxidants on proteins may be modified by overexpression of uncoupling protein 3 (UCP3) in skeletal muscle cells exposed to hyperoxia or H(2)O(2).	Water	162-167	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	107-111
19101552-2	2009	UCP3 overexpression significantly attenuated the increase in protein carbonylation in response to hyperoxia and H(2)O(2) exposures.	Water	112-117	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	0-4
18761029-6	2009	Ghrelin also affected water intake, but with less consistency across the conditions.	Water	22-27	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
19046076-0	2009	On the nature of the reversibility of hydration-dehydration on the crystal structure and magnetism of the ferrimagnet [MnII(enH)(H2O)][CrIII(CN)6].H2O.	Water	129-132	PDZ and LIM domain 5	Homo sapiens	124-127
24444391-5	2014	NOD mice consuming 0.2% EGCG daily dissolved in water showed higher protein levels of peroxiredoxin 6 (PRDX6), a major anti-oxidant defense protein, and catalase, while the untreated NOD mice exhibited significantly lowered levels of PRDX6.	Water	48-53	peroxiredoxin 6	Mus musculus	86-101
19526476-1	2009	Involuntary association: Anionic beta-galactosidase enzymes associate with positively charged Au nanoparticles to produce reduced-charge conjugates, which assemble at oil-water interfaces to result in stable microcapsules (see picture).	Water	171-176	galactosidase beta 1	Homo sapiens	33-51
18945830-11	2009	We conclude that changes in CLC-K1, UT-A1, UT-A3, and TonEBP play important roles in the renal response to osmotic diuresis in an attempt to minimize changes in plasma osmolality and maintain water homeostasis.	Water	192-197	nuclear factor of activated T-cells 5	Rattus norvegicus	54-60
18945954-4	2009	Zebrafish CA IX was highly expressed in the eye, brain, and gastrointestinal tract and showed increased expression in the eye, brain, and muscle in response to hypoxia (water Po(2) = 24 mmHg).	Water	169-174	carbonic anhydrase 9	Homo sapiens	10-15
24444391-5	2014	NOD mice consuming 0.2% EGCG daily dissolved in water showed higher protein levels of peroxiredoxin 6 (PRDX6), a major anti-oxidant defense protein, and catalase, while the untreated NOD mice exhibited significantly lowered levels of PRDX6.	Water	48-53	peroxiredoxin 6	Mus musculus	103-108
24444391-5	2014	NOD mice consuming 0.2% EGCG daily dissolved in water showed higher protein levels of peroxiredoxin 6 (PRDX6), a major anti-oxidant defense protein, and catalase, while the untreated NOD mice exhibited significantly lowered levels of PRDX6.	Water	48-53	peroxiredoxin 6	Mus musculus	234-239
19882607-0	2009	Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor.	Water	115-120	catechol-O-methyltransferase	Homo sapiens	44-72
19373924-1	2009	The conformational study of N-acetyl-N"-methylamide of L-3,4-dehydroproline (Ac-Dhp-NHMe, the Dhp dipeptide) is carried out using hybrid density functional methods with the self-consistent reaction field method in the gas phase and in solution (chloroform and water).	Water	260-265	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	55-58
19963769-5	2009	Blood pressures: sBP (2.8%), dBP(3.6%), and TPRI (5.3%) showed statistically significant increases after the water ingestion.	Water	109-114	selenium binding protein 1	Homo sapiens	17-20
24444391-6	2014	Similarly, pancreas samples from water-fed NOD mice were depleted in PRDX6 and superoxide dismutase, while EGCG-fed mice showed high levels of these anti-oxidant enzymes.	Water	33-38	peroxiredoxin 6	Mus musculus	69-74
24509911-0	2014	Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1.	Water	14-19	transient receptor potential cation channel subfamily V member 4	Homo sapiens	66-71
19142026-8	2009	Body weight, urine output and free water clearance increased, osmolality and the osmolar clearance decreased significantly in EGF-treated rats, despite unchanged AQP2 levels.	Water	35-40	epidermal growth factor like 1	Rattus norvegicus	126-129
19182340-3	2009	The results of kinetic analysis confirmed that the high volumetric nitrogen removal efficiency observed in the extremely shallow SSF did not depend on high response against the water temperature but on much higher basic nitrogen removal activity compared with other SSF.	Water	177-182	peter pan homolog	Homo sapiens	129-132
24509911-9	2014	Thus, physical and functional interactions between TRPV4 and ANO1 can modulate water transport in the choroid plexus.	Water	79-84	transient receptor potential cation channel subfamily V member 4	Homo sapiens	51-56
19035376-9	2008	Here, water molecules either exchange directly with the bulk or diffuse within the protein towards Arg 134/Lys129, where the exchange with the bulk occurs.	Water	6-11	eukaryotic translation initiation factor 3 subunit K	Homo sapiens	99-106
19469634-3	2009	Water extract of the roots of R. nasutus (RNR) was given to the animals intragastrically daily in the initiation and promotion phases.	Water	0-5	renin 2 tandem duplication of Ren1	Mus musculus	42-45
24272958-9	2014	Immunohistochemistry revealed alterations in the cellular distribution of the water channel aquaporin 4 in astrocytes of ASPA(Nur7/Nur7) mice.	Water	78-83	aspartoacylase	Mus musculus	121-125
19363236-1	2009	3,4-dihydroxy-phenyl lactic acid (DLA) and salvianolic acid B (SAB) are two major water-soluble components of Salvia miltiorrhiza (SM).	Water	82-87	SH3-domain binding protein 5	Rattus norvegicus	63-66
19053804-4	2008	In all four complexes, TGA and XRD show loss and reuptake of water ligands.	Water	61-66	T-box transcription factor 1	Homo sapiens	23-26
24272958-9	2014	Immunohistochemistry revealed alterations in the cellular distribution of the water channel aquaporin 4 in astrocytes of ASPA(Nur7/Nur7) mice.	Water	78-83	aspartoacylase	Mus musculus	126-130
24272958-9	2014	Immunohistochemistry revealed alterations in the cellular distribution of the water channel aquaporin 4 in astrocytes of ASPA(Nur7/Nur7) mice.	Water	78-83	aspartoacylase	Mus musculus	131-135
18835240-8	2008	There was also a significant activation of ERK1/2 by 1mM H(2)O(2) and resveratrol was able to completely prevent this activation, leading to activity values lower than control levels.	Water	57-62	mitogen activated protein kinase 3	Rattus norvegicus	43-49
19089325-6	2009	GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation.	Water	84-89	guanylate cyclase 2C	Homo sapiens	0-4
24754561-2	2014	In this system, H( ) (or HO2( ) in the presence of dissolved oxygen) and H2O2 produced by the radiolytic decomposition of water both reduce Ce(4+) ions to Ce(3+) ions, while ( )OH radicals oxidize the Ce(3+) present in the solution back to Ce(4+).	Water	122-127	heme oxygenase 2	Homo sapiens	25-28
18983920-6	2009	When expressed in Xenopus oocytes, ApAQP1 showed the hallmarks of aquaporin-mediated water transport, including an 18-fold increase in the osmotic water permeability of the oolemma, a reduced activation energy, and inhibition of elevated water transport activity by Hg ions.	Water	85-90	aquaporin	Xenopus laevis	66-75
18983920-6	2009	When expressed in Xenopus oocytes, ApAQP1 showed the hallmarks of aquaporin-mediated water transport, including an 18-fold increase in the osmotic water permeability of the oolemma, a reduced activation energy, and inhibition of elevated water transport activity by Hg ions.	Water	147-152	aquaporin	Xenopus laevis	66-75
18983920-6	2009	When expressed in Xenopus oocytes, ApAQP1 showed the hallmarks of aquaporin-mediated water transport, including an 18-fold increase in the osmotic water permeability of the oolemma, a reduced activation energy, and inhibition of elevated water transport activity by Hg ions.	Water	147-152	aquaporin	Xenopus laevis	66-75
19330092-3	2008	This study showed that modification of the composites with MAPE coupling agent increased the surface smoothness and reduced the water absorption and thickness swelling of the panels.	Water	128-133	PRAME nuclear receptor transcriptional regulator	Homo sapiens	59-63
18753266-4	2008	Baseline water and NaCl (0.3 M) intakes were significantly elevated in NSE-AT(1A) compared with nontransgenic littermates, and bolus intracerebroventricular injections of ANG II (200 ng in 200 nl) caused further enhanced water intake in NSE-AT(1A).	Water	9-14	enolase 2, gamma neuronal	Mus musculus	71-74
19638673-3	2009	Wild type alleles code puroindoline a (PINA) and puroindoline b (PINB) proteins, which form a 15-kDa friabilin present on the surface of water-washed starch granules.	Water	137-142	LOC543301	Triticum aestivum	49-63
24053164-2	2014	We analyzed the effects of dehydration induced by water deprivation for 3 days on the activities of ERK1/2 and transcription factors, Elk1 and cAMP response element-binding protein (CREB) in vasopressinergic neurons, as well as the distribution and level of the motor protein, kinesin, in the hypothalamo-neurohypophyseal system.	Water	50-55	mitogen activated protein kinase 3	Rattus norvegicus	100-106
19638673-3	2009	Wild type alleles code puroindoline a (PINA) and puroindoline b (PINB) proteins, which form a 15-kDa friabilin present on the surface of water-washed starch granules.	Water	137-142	LOC543301	Triticum aestivum	65-69
19088496-1	2009	OBJECTIVE: To explore the pathological change of water homeostasis in the secretory otitis media (SOM) middle ear, we observed the expression and regulation of aquaporin 1 (AQP1) in the SOM middle ear cavity.	Water	49-54	aquaporin-1	Cavia porcellus	160-171
19088496-1	2009	OBJECTIVE: To explore the pathological change of water homeostasis in the secretory otitis media (SOM) middle ear, we observed the expression and regulation of aquaporin 1 (AQP1) in the SOM middle ear cavity.	Water	49-54	aquaporin-1	Cavia porcellus	173-177
18752831-3	2008	Rates of degradation of MC-LR, MC-LF and NOD in individual water samples ranged from a half-life of 4 to 18d.	Water	59-64	atrophin 1	Homo sapiens	41-44
24402080-6	2014	Negative pressure (-30 cm H2O) and acidification of intracellular solution (pH 6.8 or 6.3) both enhanced TREK-1 channel open probability significantly.	Water	26-29	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	105-111
18706888-2	2008	To clarify the mechanism of hydrogen"s effect in the brain, we administered hydrogen-rich pure water (H(2)) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant.	Water	95-100	regucalcin	Mus musculus	141-146
18706888-2	2008	To clarify the mechanism of hydrogen"s effect in the brain, we administered hydrogen-rich pure water (H(2)) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant.	Water	95-100	regucalcin	Mus musculus	148-189
18821763-4	2008	Analysis of the kinetics of the reaction at 28 mM water indicates that second order rate constant for the catalytic reaction, given as kcatmax/Kd, is 4.6 x 104 M(-1) s(-1), is a factor of 8.4 x 10(10) larger than the second order rate constant (k2EtO) for the ethoxide promoted reaction of 2 in ethanol (5.5 +/- 0.3) x 10(-7) M(-1) s(-1).	Water	50-55	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	247-250
19347744-0	2009	Patients referred to an indoor air health clinic: exposure to water-damaged buildings causes an increase of lymphocytes in bronchoalveolar lavage and a decrease of CD19 leucocytes in peripheral blood.	Water	62-67	CD19 molecule	Homo sapiens	164-168
19347744-11	2009	Exposure to water damage caused a significant change in the cellular composition in BAL fluid (lymphocytosis) and blood (decrease of CD19 cells).	Water	12-17	CD19 molecule	Homo sapiens	133-137
19844064-1	2009	We describe a novel assay for simple, rapid and high-sensitive detection of Cryptosporidium oocysts in water samples using a reverse transcription-loop-mediated isothermal amplification (RT-LAMP).	Water	103-108	lysosomal associated membrane protein 3	Homo sapiens	190-194
19844064-4	2009	The developed RT-LAMP assay could more sensitively detect Cryptosporidium oocysts in real water samples than the conventional assay based on microscopic observation.	Water	90-95	lysosomal associated membrane protein 3	Homo sapiens	17-21
24389419-2	2014	The purpose of this study was to examine the effects of pre-injections of losartan (AT1 angiotensin receptor antagonist) into the CeA on 0.3 M NaCl and water intake induced by DAMGO injected bilaterally in the same area in rats submitted to water deprivation-partial rehydration (WD-PR) and in rats treated with the diuretic furosemide (FURO) combined with a low dose of the angiotensin-converting enzyme inhibitor captopril (CAP) injected subcutaneously (FURO/CAP).	Water	152-157	angiotensin II receptor, type 1a	Rattus norvegicus	84-87
19955646-5	2009	However, in estuary water samples containing relatively high concentration of sewage contamination, a linear correlation does exist between BOD(5) and COD.	Water	20-25	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	151-154
18811183-7	2008	Consequently, Pu(VIII) is in an unstable oxidation state and easily reduced back to Pu(VII) by the solvent water molecules.	Water	107-112	cytochrome c oxidase subunit 8A	Homo sapiens	17-21
18707179-0	2008	The effects of water vapor on the CH3O2 self-reaction and reaction with HO2.	Water	15-20	heme oxygenase 2	Homo sapiens	72-75
18707179-3	2008	The HO2 self-reaction rate constant is significantly enhanced by water vapor, consistent with what others have reported, whereas the CH3O2 self-reaction and the cross-reaction (CH3O2 + HO2) rate constants are nearly unaffected.	Water	65-70	heme oxygenase 2	Homo sapiens	4-7
18707179-4	2008	The enhancement in the HO2 self-reaction rate coefficient occurs because of the formation of a strongly bound (6.9 kcal mol(-1)) HO2 x H2O complex during the reaction mechanism where the H2O acts as an energy chaperone.	Water	135-138	heme oxygenase 2	Homo sapiens	23-26
18707179-4	2008	The enhancement in the HO2 self-reaction rate coefficient occurs because of the formation of a strongly bound (6.9 kcal mol(-1)) HO2 x H2O complex during the reaction mechanism where the H2O acts as an energy chaperone.	Water	135-138	heme oxygenase 2	Homo sapiens	129-132
24389419-2	2014	The purpose of this study was to examine the effects of pre-injections of losartan (AT1 angiotensin receptor antagonist) into the CeA on 0.3 M NaCl and water intake induced by DAMGO injected bilaterally in the same area in rats submitted to water deprivation-partial rehydration (WD-PR) and in rats treated with the diuretic furosemide (FURO) combined with a low dose of the angiotensin-converting enzyme inhibitor captopril (CAP) injected subcutaneously (FURO/CAP).	Water	152-157	carcinoembryonic antigen gene family 4	Rattus norvegicus	130-133
18707179-4	2008	The enhancement in the HO2 self-reaction rate coefficient occurs because of the formation of a strongly bound (6.9 kcal mol(-1)) HO2 x H2O complex during the reaction mechanism where the H2O acts as an energy chaperone.	Water	187-190	heme oxygenase 2	Homo sapiens	23-26
18707179-4	2008	The enhancement in the HO2 self-reaction rate coefficient occurs because of the formation of a strongly bound (6.9 kcal mol(-1)) HO2 x H2O complex during the reaction mechanism where the H2O acts as an energy chaperone.	Water	187-190	heme oxygenase 2	Homo sapiens	129-132
19088188-5	2008	The crystal structures of the SET8 Y334F mutant bound to histone H4 peptides bearing unmodified, monomethyl, and dimethyl Lys-20 reveal that the phenylalanine substitution attenuates hydrogen bonding to a structurally conserved water molecule adjacent to the Phe/Tyr switch, facilitating its dissociation.	Water	228-233	lysine methyltransferase 5A	Homo sapiens	30-34
24389419-4	2014	In WD-PR rats, bilateral injections of DAMGO (2 nmol in 0.5 muL) into the CeA induced 0.3 M NaCl and water intake, and pre-treatment with losartan (108 nmol in 0.5 muL) injected into the CeA reduced 0.3 M NaCl and water intake induced by DAMGO.	Water	101-106	carcinoembryonic antigen gene family 4	Rattus norvegicus	74-77
24389419-5	2014	In FURO/CAP rats, pre-treatment with losartan (108 nmol in 0.5 muL) injected into the CeA attenuated the increase in 0.3M NaCl and water intake induced by DAMGO (2 nmol in 0.5 muL) injected into the same site.	Water	131-136	carcinoembryonic antigen gene family 4	Rattus norvegicus	86-89
19367812-1	2008	The effect of block sequence on the self-assembly of ABC terpolymers in selective solvent (water/THF) was explored based on two kinds of terpolymers: polystyrene-block-poly(ethylene oxide)-block-poly(acrylic acid) (PS-b-PEO-b-PAA) and PEO-b-PS-b-PAA with the same component, comparable molecular weight, but different block sequence.	Water	91-96	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	53-56
18809654-7	2008	These findings strongly suggested that a polymer-type water-soluble PGN fragment, SEPS, exhibits both TLR2-and NOD2-agonistic activities, which induced the synergistic activation of human monocytic cells.	Water	54-59	nucleotide binding oligomerization domain containing 2	Homo sapiens	111-115
24677167-6	2014	For the [{Cu(hfac)2}2(DR1)(H2O)] complex, sufficiently strong ferromagnetic interactions (J1/k=42.7 and J2/k=14.1 K) between two coordinating CuII ions and DR1 were revealed.	Water	27-30	down-regulator of transcription 1	Homo sapiens	22-25
18257032-2	2008	For hydration water that has relatively high mobility and shows Lorentzian decay, molecular mobility as determined by spin-spin relaxation time (T(2)) was correlated with ease of evaporation under both nonisothermal and isothermal conditions, as determined by DSC and water vapor sorption isotherm analysis, respectively.	Water	14-19	desmocollin 3	Homo sapiens	260-263
19007166-8	2008	The adhesive strength and water resistance of glycinin dropped significantly at lower levels of sodium bisulfite and then increased as the amount of sodium bisulfite increased up to 24 g/L.	Water	26-31	LOC732636	Glycine max	46-54
24677167-6	2014	For the [{Cu(hfac)2}2(DR1)(H2O)] complex, sufficiently strong ferromagnetic interactions (J1/k=42.7 and J2/k=14.1 K) between two coordinating CuII ions and DR1 were revealed.	Water	27-30	down-regulator of transcription 1	Homo sapiens	156-159
19052371-2	2008	The thermophilic homologue of mitoNEET (TTHA0026) from Thermus thermophilus HB8 has been heterologously overproduced in Escherichia coli and purified as a water-soluble prototypal protein containing the mitoNEET-like [2Fe-2S] cluster.	Water	155-160	CDGSH iron-sulfur domain-containing protein	Thermus thermophilus HB8	40-48
18553175-6	2008	Moreover, the blocking of the Ras function by the farnesyltransferase inhibitor, alpha-hydroxyfarnesylphosphonic acid, led to a 40% or greater reduction in Raf-1 kinase activity, suggesting that Ras is involved in the signaling pathway mediating the H(2)O(2) activation of Raf-1.	Water	250-255	zinc fingers and homeoboxes 2	Homo sapiens	156-159
18553175-6	2008	Moreover, the blocking of the Ras function by the farnesyltransferase inhibitor, alpha-hydroxyfarnesylphosphonic acid, led to a 40% or greater reduction in Raf-1 kinase activity, suggesting that Ras is involved in the signaling pathway mediating the H(2)O(2) activation of Raf-1.	Water	250-255	zinc fingers and homeoboxes 2	Homo sapiens	273-276
24677167-7	2014	In [{Cu(hfac)2}2(DR1)(H2O)][Cu(hfac)2(H2O)], the very strong and antiferromagnetic (J/k=-416.1 K) exchange interaction between one of the coordinating CuII ions and DR1 is caused by the very short equatorial CuO bond length (1.962 A).	Water	22-25	down-regulator of transcription 1	Homo sapiens	17-20
24677167-7	2014	In [{Cu(hfac)2}2(DR1)(H2O)][Cu(hfac)2(H2O)], the very strong and antiferromagnetic (J/k=-416.1 K) exchange interaction between one of the coordinating CuII ions and DR1 is caused by the very short equatorial CuO bond length (1.962 A).	Water	22-25	down-regulator of transcription 1	Homo sapiens	165-168
24677167-7	2014	In [{Cu(hfac)2}2(DR1)(H2O)][Cu(hfac)2(H2O)], the very strong and antiferromagnetic (J/k=-416.1 K) exchange interaction between one of the coordinating CuII ions and DR1 is caused by the very short equatorial CuO bond length (1.962 A).	Water	38-41	down-regulator of transcription 1	Homo sapiens	17-20
18657370-6	2008	Overall, there were 93% more significant changes in TRH and TRH-like peptide levels in brain and 111% more in peripheral tissues of those rats ingesting various doses of CORT in drinking water compared to those with 1-3 s.c. pellets.	Water	187-192	cortistatin	Rattus norvegicus	170-174
24677167-7	2014	In [{Cu(hfac)2}2(DR1)(H2O)][Cu(hfac)2(H2O)], the very strong and antiferromagnetic (J/k=-416.1 K) exchange interaction between one of the coordinating CuII ions and DR1 is caused by the very short equatorial CuO bond length (1.962 A).	Water	38-41	down-regulator of transcription 1	Homo sapiens	165-168
18657370-7	2008	We conclude that providing rats with CORT in drinking water is a convenient model for the pathophysiological effects of hyperglucocorticoidemia in rodents.	Water	54-59	cortistatin	Rattus norvegicus	37-41
19053855-0	2008	Grifola frondosa (maitake mushroom) water extract inhibits vascular endothelial growth factor-induced angiogenesis through inhibition of reactive oxygen species and extracellular signal-regulated kinase phosphorylation.	Water	36-41	vascular endothelial growth factor A	Gallus gallus	59-93
24070090-7	2014	Leukocyte activation abated in the presence of inhibitors of HMGB1 or of catalase, which catalyzes the dismutation of hydrogen peroxide into water and molecular oxygen.	Water	141-146	high mobility group box 1	Homo sapiens	61-66
18528847-3	2008	The present work has shown that anisotropic and water-stable films are produced when fibroin solution is cast under an alternating electric field (AC).	Water	48-53	fibroin light chain	Bombyx mori	85-92
24334548-1	2014	Aquaporin 1 (AQP1) is a plasma membrane water-transporting protein expressed strongly in tumor microvascular endothelia.	Water	40-45	aquaporin 1	Mus musculus	0-11
24334548-1	2014	Aquaporin 1 (AQP1) is a plasma membrane water-transporting protein expressed strongly in tumor microvascular endothelia.	Water	40-45	aquaporin 1	Mus musculus	13-17
18980127-6	2008	The proposed method has been successfully applied in the analysis of T1(III) in standard reference materials, synthetic mixtures, and water and urine samples.	Water	134-139	interleukin 1 receptor like 1	Homo sapiens	69-76
24252381-1	2014	The mineralocorticoid receptor (MR) is a ligand-dependent transcription factor that physiologically regulates water-electrolyte homeostasis and controls blood pressure.	Water	110-115	nuclear receptor subfamily 3 group C member 2	Homo sapiens	4-30
24252381-1	2014	The mineralocorticoid receptor (MR) is a ligand-dependent transcription factor that physiologically regulates water-electrolyte homeostasis and controls blood pressure.	Water	110-115	nuclear receptor subfamily 3 group C member 2	Homo sapiens	32-34
18664402-5	2008	EXAFS and infrared spectroscopic measurements on pure water have shown previously that the ratios of ortho and para isomers of the hydrogen atoms of water occur on a similar time scale and produce regular patterns of unequally spaced oscillations similar to those observed with ECTO-NOX proteins and Cu(II)Cl(2) solutions.	Water	54-59	tripartite motif containing 33	Homo sapiens	278-282
18664402-5	2008	EXAFS and infrared spectroscopic measurements on pure water have shown previously that the ratios of ortho and para isomers of the hydrogen atoms of water occur on a similar time scale and produce regular patterns of unequally spaced oscillations similar to those observed with ECTO-NOX proteins and Cu(II)Cl(2) solutions.	Water	149-154	tripartite motif containing 33	Homo sapiens	278-282
24984482-5	2014	The fractal dimension (D) of mechanical stability in soil aggregates followed the order of CD&gt;HD&gt;ST&gt;RGL&gt;CSL&gt;GC and the water stability was in the order of GC&gt;CSL&gt;RGL&gt;HD&gt; CD&gt;ST.	Water	134-139	ral guanine nucleotide dissociation stimulator like 1	Homo sapiens	183-186
24765025-2	2014	In the crystal, mol-ecules are linked into chains running parallel to the a axis by association of the bromide ions and the water mol-ecules of crystallization with the cations via N-H O, O-H Br, C-H N and C-H Br hydrogen-bonding inter-actions.	Water	124-129	chimerin 1	Homo sapiens	196-209
18652446-7	2008	The coordinated H 2O molecules in 2 are more easily removed than those in 1 because of the strong Lewis basicity of the BF 4 (-) anion compared to the PF 6 (-) ion.	Water	16-20	sperm associated antigen 17	Homo sapiens	151-155
24550314-0	2014	Variation in MPK12 affects water use efficiency in Arabidopsis and reveals a pleiotropic link between guard cell size and ABA response.	Water	27-32	mitogen-activated protein kinase 12	Arabidopsis thaliana	13-18
18456318-6	2008	The AGA-(C8R)HNG17 peptide exhibited extensive beta-sheet structure in water, completely different from the aqueous HN and HNG structures.	Water	71-76	neurogranin	Homo sapiens	13-16
24551113-5	2014	In this work, we characterize the mechanical properties of human islet amyloid polypeptide (hIAPP) fibrils with respect to their molecular structures as well as their amino acid sequence by using all-atom explicit water molecular dynamics (MD) simulation.	Water	214-219	islet amyloid polypeptide	Homo sapiens	92-97
18504558-5	2008	These sorbents, when used in combination with ultraviolet diffuse reflectance spectroscopy (UV DRS), can be employed as a rapid screening method for detection of aromatic compounds in water and air environmental matrices.	Water	184-189	sushi repeat containing protein X-linked	Homo sapiens	95-98
18597052-1	2008	In this study, a novel pH-sensitive and reversible water-soluble polymer(P(ABC)) forming aqueous two-phase systems(ATPS) was synthesized by using 2-(dimethylamino)ethyl methacrylate, t-butyl methacrylate, and methyl methacrylate as monomers and 2,2"-azo-bis-isobutyronitrile as initiator.	Water	51-56	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	75-78
18700282-4	2008	Our results show that water maze training induces a rapid recruitment of NMDAR subunits (NR1, NR2A, NR2B) and PSD-95 to synaptic lipid rafts and decrease in the post-synaptic density plus an increase of NR2B phosphorylation at tyrosine 1472 in the rat insular cortex.	Water	22-27	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	89-92
18700282-4	2008	Our results show that water maze training induces a rapid recruitment of NMDAR subunits (NR1, NR2A, NR2B) and PSD-95 to synaptic lipid rafts and decrease in the post-synaptic density plus an increase of NR2B phosphorylation at tyrosine 1472 in the rat insular cortex.	Water	22-27	discs large MAGUK scaffold protein 4	Rattus norvegicus	110-116
18555566-0	2008	Adjuvant effect of water-soluble polysaccharide (PAP) from the mycelium of Polyporus albicans on the immune responses to ovalbumin in mice.	Water	19-24	phospholipid phosphatase 1	Mus musculus	49-52
18555566-1	2008	In our previous work, a new water-soluble polysaccharide (PAP) from the mycelium of Polyporus albicans was identified for the first time.	Water	28-33	phospholipid phosphatase 1	Mus musculus	58-61
18477469-3	2008	GSK-3 inhibitor VIII was more effective than inhibitor II, and infarct volume and water content in the VIII group were significantly decreased 24h after the onset of ischemic stroke, as compared with the control group.	Water	82-87	cytochrome c oxidase subunit 8A	Homo sapiens	103-107
27879927-7	2008	Imagery acquired shortly after Hurricane Rita made landfall showed increased water column turbidity extending over a large area of the shelf off Louisiana and Texas, consistent with intense resuspension and sediment disturbance.	Water	77-82	RBPJ interacting and tubulin associated 1	Homo sapiens	41-45
18080132-4	2008	The distribution of the water channel aquaporin-1 (AQP1), as well as its molecular structure ensuring an exquisite selectivity for water, fit with the characteristics of the ultrasmall pore.	Water	24-29	aquaporin 1	Mus musculus	38-49
18080132-4	2008	The distribution of the water channel aquaporin-1 (AQP1), as well as its molecular structure ensuring an exquisite selectivity for water, fit with the characteristics of the ultrasmall pore.	Water	24-29	aquaporin 1	Mus musculus	51-55
18080132-4	2008	The distribution of the water channel aquaporin-1 (AQP1), as well as its molecular structure ensuring an exquisite selectivity for water, fit with the characteristics of the ultrasmall pore.	Water	131-136	aquaporin 1	Mus musculus	38-49
18080132-4	2008	The distribution of the water channel aquaporin-1 (AQP1), as well as its molecular structure ensuring an exquisite selectivity for water, fit with the characteristics of the ultrasmall pore.	Water	131-136	aquaporin 1	Mus musculus	51-55
18080132-5	2008	Peritoneal transport studies using AQP1 knockout mice demonstrated that the osmotic water flux across the peritoneal membrane is mediated by AQP1.	Water	84-89	aquaporin 1	Mus musculus	35-39
18080132-5	2008	Peritoneal transport studies using AQP1 knockout mice demonstrated that the osmotic water flux across the peritoneal membrane is mediated by AQP1.	Water	84-89	aquaporin 1	Mus musculus	141-145
18080132-7	2008	Treatment with high-dose corticosteroids upregulates the expression of AQP1 in peritoneal capillaries, resulting in increased water transport and ultrafiltration in rats.	Water	126-131	aquaporin 1	Rattus norvegicus	71-75
18512960-12	2008	The dependence of the occurrence of methyl transfer on the formation of a water channel in SET8 is in accord with our previous reports on product specificity by histone lysine monomethyltransferase SET7/9, large subunit lysine dimethyltransferase (LSMT), and viral histone lysine trimethyltransferase (vSET).	Water	74-79	lysine methyltransferase 5A	Homo sapiens	91-95
18614997-6	2008	The physiological relevance of our in vitro data was confirmed by water deprivation of male C57BL6 mice, which caused a significant increase in serum osmolality along with induction of CLC-K1, barttin and SGK1.	Water	66-71	chloride channel, voltage-sensitive Ka	Mus musculus	185-191
18718505-7	2008	Results showed an increase in the brain water content and the presence of Evans blue in the brain tissue of thermally injured rats, temporally associated with an increased expression of endogenous tPA and uPA.	Water	40-45	plasminogen activator, urokinase	Rattus norvegicus	205-208
18506810-5	2008	However, long-lived association of both water and ethanol with the polar side chains of Tyr3 and Trp6 is indicated by the data.	Water	40-45	transient receptor potential cation channel subfamily C member 6	Homo sapiens	97-101
18662688-1	2008	The purpose of the study was to identify non-covalently held complexes that exist in the water-soluble high molecular weight (WS-HMW) protein fractions of normal human lenses of 20-year-old and 60- to 70-year-old, and in the age-matched 60- to 70-year-old cataractous lenses.	Water	89-94	cilia and flagella associated protein 97	Homo sapiens	129-132
18952773-10	2008	It is proposed that during evolution, NIP5;1 and NIP6;1 were diversified in terms of both the specificity of their expression in plant tissues and their water permeation properties, while maintaining their ability to be induced under low B and their boric acid transport activities.	Water	153-158	NOD26-like intrinsic protein 5;1	Arabidopsis thaliana	38-44
24551164-3	2014	The objective of this study was to evaluate the efficacy of the down-regulation of the prion protein (PrP) expression using siRNA delivered by, a water-in-oil microemulsion, as a therapeutic candidate in a preclinical study.	Water	146-151	prion protein	Mus musculus	102-105
24030355-4	2014	Data indicate that H19, a paternally imprinted gene, compared to control embryos, was less methylated in 8-cell embryos from pregnant mice treated with NaF (100 mg/l) in drinking water for 48 h. Peg3, a maternally imprinted gene, and the Line1 repeated sequence were similarly methylated in NaF-treated and control embryos.	Water	179-184	H19, imprinted maternally expressed transcript	Mus musculus	19-22
18686978-3	2008	The temperature ranges of the induced smectic A 2 (SmA 2) liquid-crystalline phases can be very broad and the onset temperatures can be below room temperature depending upon the concentration of the alcohol or water and the structure of the alcohol.	Water	210-215	survival of motor neuron 1, telomeric	Homo sapiens	38-49
18686978-3	2008	The temperature ranges of the induced smectic A 2 (SmA 2) liquid-crystalline phases can be very broad and the onset temperatures can be below room temperature depending upon the concentration of the alcohol or water and the structure of the alcohol.	Water	210-215	survival of motor neuron 1, telomeric	Homo sapiens	51-56
18693734-6	2008	The dehydration that is catalyzed by the dehydratase (DH) domains of TYLS module 2 to give the unsaturated (2E,4S,5R)-2,4-dimethyl-5-hydroxyhept-2-enoyl-ACP2 is therefore a syn elimination of water.	Water	192-197	acid phosphatase 2, lysosomal	Homo sapiens	153-157
24476486-0	2014	Women reduced the sex difference in open-water ultra-distance swimming [Formula: see text] La Traversee Internationale du Lac St-Jean, 1955-2012.	Water	41-46	lactase	Homo sapiens	122-125
18974599-8	2008	HEVs strongly express Aquaporin-1, suggesting that HEVs are involved in the net absorption of water, but not protein, from lymph coming through afferent lymphatics.	Water	94-99	aquaporin 1	Rattus norvegicus	22-33
24286224-8	2014	By generating point mutations in the selectivity filter of rat orthodox aquaporin AQP1, we established a correlation of H2O2 permeability primarily with water permeability and secondarily with the pore diameter.	Water	153-158	aquaporin 1	Rattus norvegicus	82-86
18775802-6	2008	When single, water-phenol extraction was performed, B. quintana LPS, stimulated cytokine production in a TLR2-dependent manner.	Water	13-18	toll-like receptor 2	Mus musculus	105-109
24355552-6	2014	There were 154 and 182 unique named genes that significantly differed (FDR=0.2) between the water and ethanol group in the Acb-sh and CeA, respectively.	Water	92-97	carcinoembryonic antigen gene family 4	Rattus norvegicus	134-137
19068615-1	2008	To obtain the temporal and spatial distribution and partition of PAH between water and particles in coastal area, water samples were collected from the Pearl River Estuary in July 2002 (summer) and April 2003 (spring) and polycyclic aromatic hydrocarbons (PAHs) were analysed with GC-MS in the present study.	Water	77-82	phenylalanine hydroxylase	Homo sapiens	65-68
19068615-2	2008	Total PAH concentrations in water samples were higher in spring (c(p): 4.0-39.1 ng/L; c(w): 15.9-184.2 ng/L) than in summer (c(p): 2.6-26.6 ng/L; c(w): 13.0-28.3 ng/L).	Water	28-33	phenylalanine hydroxylase	Homo sapiens	6-9
19068615-3	2008	Suspended particle matter (SPM) content, photogradation and riverine discharge were the major factors controlling the PAH concentrations in water.	Water	140-145	phenylalanine hydroxylase	Homo sapiens	118-121
19068615-7	2008	The partition coefficient (Kp) increased with the particular organic carbon content of SPM and salinity of water and decreased with the SPM content of samples, which were consistent with the PAH partition theory.	Water	107-112	phenylalanine hydroxylase	Homo sapiens	191-194
18456254-7	2008	These results suggest that 5-HT(3) receptors are involved in both abnormal colonic water transport and defecation induced by CRF, and that the inhibitory effects of 5-HT(3) receptor antagonists on CRF-induced abnormal defecation partly result from their ameliorating action on colonic water transport.	Water	83-88	5-hydroxytryptamine receptor 3A	Rattus norvegicus	27-43
18545666-8	2008	Like this, high H(2)O(2) or directed mutation of redox-sensitive ERK2 Cys(214) impeded binding to MEK1/2, caused ERK2 retention in mitochondria and restricted shuttle to nuclei.	Water	16-21	mitogen-activated protein kinase kinase 1	Mus musculus	98-104
24144934-2	2014	The soil samples were sub sectioned and analyzed to determine the concentrations of chloride, sodium and COD in the pore water.	Water	121-126	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	105-108
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	Water	119-124	sperm associated antigen 17	Homo sapiens	87-90
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	Water	168-173	sperm associated antigen 17	Homo sapiens	87-90
18582946-2	2008	In analogy to in silico studies, [Ru(eta(6)-p-cymene)Cl(H(2)O)(PTA)](+) was found to be the most abundant hydrolysis product, although the dihydrolysed species [Ru(eta(6)-p-cymene)(OH)(H(2)O)(PTA)](+) and the dichloro compound are present.	Water	56-61	endothelin receptor type A	Homo sapiens	37-40
18582946-2	2008	In analogy to in silico studies, [Ru(eta(6)-p-cymene)Cl(H(2)O)(PTA)](+) was found to be the most abundant hydrolysis product, although the dihydrolysed species [Ru(eta(6)-p-cymene)(OH)(H(2)O)(PTA)](+) and the dichloro compound are present.	Water	56-61	endothelin receptor type A	Homo sapiens	164-167
18582946-2	2008	In analogy to in silico studies, [Ru(eta(6)-p-cymene)Cl(H(2)O)(PTA)](+) was found to be the most abundant hydrolysis product, although the dihydrolysed species [Ru(eta(6)-p-cymene)(OH)(H(2)O)(PTA)](+) and the dichloro compound are present.	Water	185-190	endothelin receptor type A	Homo sapiens	37-40
24355687-12	2014	The reduced radioactivity in the mine water was due to greater than 90% removal of U and Th radioactive materials from the mine water after treatment with coal fly ash as ThO2 and UO2.	Water	38-43	tho2	Drosophila melanogaster	171-175
18953092-7	2008	Centrally applied ghrelin increased body weight after the 2(nd) injection till the end of treatment (p &lt; 0.05), which was followed by increased food and water intake (p &lt; 0.05).	Water	156-161	ghrelin and obestatin prepropeptide	Rattus norvegicus	18-25
18491992-5	2008	TSC increases the rate of oxygen diffusion between the erythrocytes and the tissues by altering the "structure" of water in blood plasma.	Water	115-120	solute carrier family 12 member 3	Homo sapiens	0-3
24355687-12	2014	The reduced radioactivity in the mine water was due to greater than 90% removal of U and Th radioactive materials from the mine water after treatment with coal fly ash as ThO2 and UO2.	Water	128-133	tho2	Drosophila melanogaster	171-175
24231830-3	2014	We investigated water flux into three representative regions of the brain, namely, the cortex, basal ganglia, and third ventricle using a newly developed water molecular MRI technique based on JJ vicinal coupling between O and adjacent protons and water molecule proton exchanges (JJVCPE imaging) in AQP-1 and AQP-4 knockout mice in vivo.	Water	154-159	aquaporin 1	Mus musculus	300-305
18335234-2	2008	We recently reported that decreased expression and function of Na+/H+ exchanger type 3 (NHE-3) in proximal tubules and epithelial Na+ channels and aquaporin 2 in collecting ducts are major mechanisms involved in Na+ and water imbalances shortly after transplantation in rat undergoing acute rejection.	Water	220-225	solute carrier family 9 member A3	Rattus norvegicus	63-86
18335234-2	2008	We recently reported that decreased expression and function of Na+/H+ exchanger type 3 (NHE-3) in proximal tubules and epithelial Na+ channels and aquaporin 2 in collecting ducts are major mechanisms involved in Na+ and water imbalances shortly after transplantation in rat undergoing acute rejection.	Water	220-225	solute carrier family 9 member A3	Rattus norvegicus	88-93
24231830-3	2014	We investigated water flux into three representative regions of the brain, namely, the cortex, basal ganglia, and third ventricle using a newly developed water molecular MRI technique based on JJ vicinal coupling between O and adjacent protons and water molecule proton exchanges (JJVCPE imaging) in AQP-1 and AQP-4 knockout mice in vivo.	Water	154-159	aquaporin 1	Mus musculus	300-305
24076070-7	2014	These correlations can be used for modeling the mechanical behavior of the hybrid layer, and are expected to aid in the design and improvement of water-compatible dentin adhesive polymers.	Water	146-151	activation induced cytidine deaminase	Homo sapiens	109-112
18403445-1	2008	This study tests the hypothesis that dysfunction of transient receptor potential vanilloid type 1 (TRPV1) channels occurs and contributes to the decrease in the glomerular filtration rate (GFR) and sodium/water excretion in Dahl salt-sensitive hypertensive rats.	Water	205-210	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-97
18403445-1	2008	This study tests the hypothesis that dysfunction of transient receptor potential vanilloid type 1 (TRPV1) channels occurs and contributes to the decrease in the glomerular filtration rate (GFR) and sodium/water excretion in Dahl salt-sensitive hypertensive rats.	Water	205-210	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	99-104
24664339-3	2014	The rate of the ligand exchange reaction did not change significantly with the addition of H2O to the DMF solvent; however, it increased when NEt3 was added to the reaction mixture.	Water	91-94	tetraspanin 2	Homo sapiens	142-146
19169376-5	2008	The studies reported here were conducted to model and understand this process by studying SAT behavior at the air-water interface.	Water	114-119	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	90-93
18558783-2	2008	The cationic functionality arises from polycations, such as PEI, poly( L-lysine), trimethyl chitosan, and (dimethylamino)ethyl methacrylate, introduced into the water phase of classical oil-in-water (o/w) solvent evaporation method of PLG microsphere fabrication.	Water	161-166	plasminogen	Homo sapiens	235-238
18583026-9	2008	Furthermore, we found that a single-headed myosin-VI-bead complex moved more processively in a high-viscous solution (40-fold higher than water) similar to cellular environment.	Water	138-143	myosin VI	Homo sapiens	43-52
18583026-10	2008	Because diffusion of the bead is 60-fold slower than myosin-VI heads alone in water, we propose a model in which the bead acts as a diffusional anchor for the myosin-VI, enhancing the head"s rebinding following detachment and supporting processive movement of the bead-monomer complex.	Water	78-83	myosin VI	Homo sapiens	53-62
18583026-10	2008	Because diffusion of the bead is 60-fold slower than myosin-VI heads alone in water, we propose a model in which the bead acts as a diffusional anchor for the myosin-VI, enhancing the head"s rebinding following detachment and supporting processive movement of the bead-monomer complex.	Water	78-83	myosin VI	Homo sapiens	159-168
18500822-4	2008	The calculated potential decrease of approximately 140 mV can explain the inhibition of Y Z oxidation in the former complexes and in turn implies that the charge localization on P D1 upon formation of the core complex increases the P680 potential to the level necessary for water oxidation.	Water	274-279	programmed cell death 1	Homo sapiens	178-182
18458367-3	2008	Furthermore, the usage of a high basic condition and a water environment are the two crucial keys in ensuring the formation of HAp in the hydrothermal/sonochemical processes.	Water	55-60	reticulon 3	Homo sapiens	127-130
18800729-3	2008	Combining with Kalman filter algorithm and spectrophotometric simultaneously determining on-line technology the water samples containing the three metal ion compounds chelated with PAN from our laboratory, Yangtze River and Jialing River were analyzed quantitatively under optimal analysis condition, and the recovery is between 90.2%-106% for samples of laboratory.	Water	112-117	adenosine deaminase 2	Homo sapiens	181-184
18454512-3	2008	This is contrary to previous findings of HO2 radical interactions with water clusters.	Water	71-76	heme oxygenase 2	Homo sapiens	41-44
18454512-4	2008	Natural bond orbital (NBO) analysis is used to analyze the bonding feature of OH to help explain the difference in behavior between OH and HO2 radicals toward a water surface.	Water	161-166	heme oxygenase 2	Homo sapiens	139-142
18412408-1	2008	Binding free energies between coenzyme (FAD and NADH) and the apoenzyme of NADH-cytochrome b5 reductase (b5R) were estimated by applying the continuum Poisson-Boltzmann (PB) model to structures sampled from molecular dynamics simulations in explicit water molecules.	Water	250-255	cytochrome b5 reductase 3	Homo sapiens	105-108
18287218-2	2008	However, suppression of cell proliferation in rats by the platform-over-water SD method has been attributed to elevated corticosterone (Cort), a potent inhibitor of cell proliferation and nonspecific correlate of this procedure.	Water	72-77	cortistatin	Rattus norvegicus	136-140
18287218-9	2008	In these latter rats, Cort intake via water was reduced by 60% during SD; upregulation of cell proliferation by reduced Cort intake may obscure inhibitory effects of sleep loss on cell proliferation.	Water	38-43	cortistatin	Rattus norvegicus	22-26
18381997-0	2008	Health effects of exposure to water-damaged New Orleans homes six months after Hurricanes Katrina and Rita.	Water	30-35	RBPJ interacting and tubulin associated 1	Homo sapiens	102-106
18205142-3	2008	The chromatographic studies suggest that PP3 strongly interacts among the three commercial hydrophobic resins leading to a drop off in selectivity, while a complete binding was achieved at low salt concentrations (below 0.5 m) and total elution only with phosphate buffer and/or water stepwise conditions.	Water	279-284	glycosylation dependent cell adhesion molecule 1	Bos taurus	41-44
18280113-5	2008	Stimulation with hydrogen peroxide (H(2)O(2), 1 mM) and A23187 (10 microM) markedly released AA in C12 cells expressing S515A and wild-type cPLA(2)alpha, but the responses in C12-S505A, C12-S727A, and C12-S505A/S515A/S727A (AAA) cells were reduced.	Water	36-41	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	140-152
17665141-0	2008	Spatio-temporal variations in water quality of Nullah Aik-tributary of the river Chenab, Pakistan.	Water	30-35	aurora kinase A	Homo sapiens	54-57
18436815-1	2008	PURPOSE: Aldehyde dehydrogenase 3a1 (Aldh3a1) represents approximately 50% of the water-soluble protein of the mouse corneal epithelial cells and thus, by analogy with the abundant lens crystallins, is considered a corneal crystallin.	Water	82-87	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	9-35
18436815-1	2008	PURPOSE: Aldehyde dehydrogenase 3a1 (Aldh3a1) represents approximately 50% of the water-soluble protein of the mouse corneal epithelial cells and thus, by analogy with the abundant lens crystallins, is considered a corneal crystallin.	Water	82-87	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	37-44
18424559-13	2008	These results illuminate a previously uncharacterized role for renal IR to reduce BP and facilitate sodium and water excretion, possibly via NO production.	Water	111-116	insulin receptor	Mus musculus	69-71
17804158-5	2008	The experimental air-water mass transfer coefficients, KGa, obtained from this study ranged from 10(-2) to 10(-3)1/min.	Water	21-26	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	55-58
18262200-1	2008	A variety of fluoroalkyl end-capped oligomers were applied to the preparation of fluorinated oligomer/hydroxyapatite (HAp) composites (particle size: 38-356 nm), which exhibit a good dispersibility in water and traditional organic solvents.	Water	201-206	reticulon 3	Homo sapiens	118-121
18262200-3	2008	In these fluorinated HAp composites thus obtained, fluoroalkyl end-capped acrylic acid oligomers and 2-methacryloyloxyethanesulfonic acid oligomer/HAp nanocomposites afforded transparent colorless solutions toward water; however, fluoroalkyl end-capped N,N-dimethylacrylamide oligomer and acryloylmorpholine oligomer were found to afford transparent colorless solutions with trace amounts of white-colored HAp precipitants under similar conditions.	Water	214-219	reticulon 3	Homo sapiens	21-24
18458694-8	2008	In the trail of human vaginal doughing water, in contrast to the control group, the levels of SP-A of VVC group were higher, which was considered to be significant (P&lt;0.05).	Water	39-44	surfactant protein A1	Homo sapiens	94-98
18242629-10	2008	Water-soluble phenol (present in low concentrations) forms aggregates with P65, which can be separated by cloud point extraction, making this study interesting for separation of phenol from the phenol-water system.	Water	0-5	RELA proto-oncogene, NF-kB subunit	Homo sapiens	75-78
18242629-10	2008	Water-soluble phenol (present in low concentrations) forms aggregates with P65, which can be separated by cloud point extraction, making this study interesting for separation of phenol from the phenol-water system.	Water	201-206	RELA proto-oncogene, NF-kB subunit	Homo sapiens	75-78
18203687-6	2008	AhR agonist activity was observed for dimethyl sulfoxide (DMSO), ethanol, and water extracts of printed newspaper, unprinted virgin paper, and black printing ink, where activation of luciferase reporter gene expression was transient, suggesting that the AhR active chemical(s) was metabolically labile.	Water	78-83	aryl hydrocarbon receptor	Homo sapiens	0-3
18318465-1	2008	A beta-glucuronidase-activated prodrug approach was applied to 10-hydroxycamptothecin, a Camptotheca alkaloid with promising antitumor activity but poor water solubility.	Water	153-158	glucuronidase beta	Homo sapiens	2-20
18184763-13	2008	ANG-(1-7) contributes to the enhanced water intake during pregnancy, allowing maintenance of the normal volume-expanded state despite diuresis produced in part by decreased AVP and AQP1.	Water	38-43	aquaporin 1	Rattus norvegicus	181-185
18545840-1	2008	Aeromonas spp is recognized as pathogenic to humans after consumption of contaminated water and food.	Water	86-91	histocompatibility minor 13	Homo sapiens	10-13
21730747-1	2008	Water-soluble poly(sodium 4-styrenesulfonate-co-acrylic acid)-grafted multiwalled carbon nanotubes (MWNT-g-P(SSS-co-AA)) with core-shell nanostructure were successfully synthesized by in situ free radical copolymerization of sodium 4-strenesulfonate (SSS) and acrylic acid (AA) in the presence of MWNTs terminated with vinyl groups; their structure was characterized by FTIR, (1)H NMR, Raman, TGA and TEM.	Water	0-5	T-box transcription factor 1	Homo sapiens	393-396
17655341-3	2008	When the mercury is negatively charged, the water forms a wetting film on mica, stabilized by electrical double layer forces.	Water	44-49	MHC class I polypeptide-related sequence A	Homo sapiens	74-78
18191867-4	2008	Double-quantum filtered correlation spectroscopy (DQF-COSY) was applied to identify DP-1 as beta-N-lactosylamlodipine by suppressing the residual water signal without affecting the sample signal and by measuring the coupling constant of the lactose anomeric proton.	Water	146-151	prostaglandin D2 receptor	Homo sapiens	84-88
18206959-12	2008	These data indicate that: (1) ERK, activated by oxidative stress, is involved only in the early phase of leptin-induced BP elevation, (2) the later phase of leptin-induced hypertension is characterized by excessive NO inactivation by superoxide, (3) the time-dependent shift from ERK to O(2)(-)-NO dependent mechanism may be associated with reduced SOD/GPx ratio, which favors formation of O(2)(-) instead of H(2)O(2).	Water	409-414	leptin	Rattus norvegicus	157-163
21693898-4	2008	Density functional simulations made with the VASP code suggested that the undoped catalyst WGS activity would be limited by the strong binding of CO intermediates, blocking the reoxidation of the reduced oxide by water.	Water	213-218	vasodilator stimulated phosphoprotein	Homo sapiens	45-49
21693898-7	2008	VASP predicted that acidic transition metal dopants such as Nb, Mo, Ta, and W would increase the oxide surface affinity for water and thus increase the turnover rate of the catalyst.	Water	124-129	vasodilator stimulated phosphoprotein	Homo sapiens	0-4
18260813-10	2008	A second cluster generated DUP-PST1-1010, found in both humans and poultry, and DUP-PST1-1079, found in water.	Water	104-109	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	84-88
17963780-4	2008	In pure aqueous solution, the J aggregates at the mica/water interface had a three-dimensional structure with the height of approximately 3 nm (multilayer structure).	Water	55-60	MHC class I polypeptide-related sequence A	Homo sapiens	50-54
18767979-6	2008	The lettuce was irrigated by water from a small stream, and water samples were positive for Stx 2 by PCR.	Water	60-65	syntaxin 2	Bos taurus	92-97
18405950-7	2008	Several genes were in common between the EtOH and both the SAC and water groups in the synaptic transmission (e.g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories.	Water	67-72	glutamate decarboxylase 1	Rattus norvegicus	137-141
19035047-6	2008	Expression of NR1, NR2A and NR2B in hippocampus of the rats drinking purified water was lower than those drinking tap water, especially at low lead exposure (50 mg/L) (P &lt; 0.05).	Water	78-83	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	14-17
19035047-8	2008	CONCLUSION: Compared with drinking tap water, drinking purified water might increase the accumulation of brain lead, lower NR1, NR2A, NR2B expression and delay the spatial learning and memory ability under chronic lead exposure in water.	Water	64-69	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	123-126
19035047-8	2008	CONCLUSION: Compared with drinking tap water, drinking purified water might increase the accumulation of brain lead, lower NR1, NR2A, NR2B expression and delay the spatial learning and memory ability under chronic lead exposure in water.	Water	64-69	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	123-126
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Water	284-289	solute carrier family 9 member A3	Rattus norvegicus	70-75
17665141-1	2008	This study reports the spatio-temporal changes in water quality of Nullah Aik, tributary of the Chenab River, Pakistan.	Water	50-55	aurora kinase A	Homo sapiens	74-77
17665141-7	2008	FA/PCA identified six significant factors (sources) which were responsible for major variations in water quality dataset of Nullah Aik.	Water	99-104	aurora kinase A	Homo sapiens	131-134
20046762-2	2008	The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm.	Water	89-94	RNA polymerase II, I and III subunit H	Homo sapiens	43-49
18398380-11	2008	The TRPV1-induced sodium and water excretion appears to be mediated by increases in glomerular filtration rate and distal tubular delivery of sodium but not by suppression of renal proximal and distal tubular reabsorption, suggesting a key role of segmental regulation of renal function by TRPV1-positive primary sensory nerves in the maintenance of sodium and water homeostasis.	Water	29-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
18601534-3	2008	We will address the ability of water-stabilized QDs to behave as effective fluorescence resonance energy transfer (FRET) donors in cells upon transferrin-receptor-(TFR) mediated endocytosis.	Water	31-36	transferrin receptor	Homo sapiens	164-167
18410888-10	2008	Reactance (representative of extracellular water) correlated with supine, sitting, and standing SBP (r = 0.55, 0.59, and 0.51, respectively; P &lt; or = .008).	Water	43-48	selenium binding protein 1	Homo sapiens	96-99
18342434-4	2008	The data obtained indicated that AEA administered via water modulates the transcription of its own receptor CB1, besides to up-regulate gene expression of sterol regulatory element binding protein (SREBP) and of the insulin-like growth factors (IGF-1 and IGF-2).	Water	54-59	cannabinoid receptor 1	Danio rerio	108-111
18342434-4	2008	The data obtained indicated that AEA administered via water modulates the transcription of its own receptor CB1, besides to up-regulate gene expression of sterol regulatory element binding protein (SREBP) and of the insulin-like growth factors (IGF-1 and IGF-2).	Water	54-59	insulin-like growth factor 1	Danio rerio	245-250
18342304-4	2008	Western blots show that Xt egg water contains a single anti-allurin cross-reactive protein whose molecular weight (20,497 Da by MALDI MS) agrees well with the molecular weight of the hypothetical gene product for a newly recognized "Crisp A" gene in the X. tropicalis genome.	Water	31-36	allurin	Xenopus tropicalis	60-67
18413745-6	2008	We found that decreasing MnSOD with small interfering RNA in MCF-7 cells resulted in (a) an associated increase in the hypoxic accumulation of HIF-1 alpha immunoreactive protein, (b) a significant increase in the levels of O(2)(*-) (P &lt; 0.01), but (c) no significant change in the steady-state level of H(2)O(2).	Water	306-311	superoxide dismutase 2	Homo sapiens	25-30
18338907-3	2008	The goal of this work was to elucidate the synergistic influence of self-originating impurities and water vapor on the degradation kinetics of the histamine H2 receptor antagonist, ranitidine HCl.	Water	100-105	histamine receptor H2	Homo sapiens	147-168
18328627-5	2008	In light-injured retinas, the immunostaining of the photoreceptor water channel aquaporin-1 disappeared along with the degeneration of the outer retina, and the outer nuclear layer contained large spherical bodies representing photoreceptor nuclei which were fused together.	Water	66-71	aquaporin 1	Mus musculus	80-91
17610126-1	2008	In this study, polyamine oxidase from maize (MPAO), which is involved in the terminal catabolism of spermidine and spermine to produce an aminoaldehyde, 1,3-diaminopropane and H(2)O(2), has been conditionally expressed at high levels in the nucleus of MCF-7 human breast cancer cells, with the aim to interfere with polyamine homeostasis and cell proliferation.	Water	176-181	polyamine oxidase 1	Zea mays	15-32
18391468-0	2008	Oral administration of a hop water extract ameliorates the development of dermatitis induced by the periodical topical application of a mite antigen in atopic dermatitis model NC/Nga mice.	Water	29-34	tetratricopeptide repeat domain 26	Mus musculus	25-28
18391468-1	2008	We investigated the inhibitory effect of an oral administration of a hop water extract (HWE) on the development of dermatitis by using NC/Nga atopic dermatitis model mice.	Water	73-78	tetratricopeptide repeat domain 26	Mus musculus	69-72
18199468-8	2008	Our findings suggest that SPMD could be of a great interest in assessing genotoxic contaminants in both raw and drinking water, with great suitability for continuous monitoring.	Water	121-126	SPPM	Homo sapiens	26-30
18266341-1	2008	The uptake of trace gases such as OH and HO2 radicals, NH3, ClONO2, N2O5, ozone, and many other gases by water, aqueous solutions of acids, and salts has been reported by numerous investigators using a variety of techniques.	Water	105-110	heme oxygenase 2	Homo sapiens	41-44
18266341-7	2008	Uptake coefficients for OH and HO2 radicals on water in wetted-wall tubes are shown to range from 0.01 to 1, and on sulfuric acid, they vary from 0.008 to 0.03.	Water	47-52	heme oxygenase 2	Homo sapiens	31-34
18186079-8	2008	Aqp4, Cx43, and Kir4.1/Kir5.1 are co-localized to astrocytic end-feet at the brain vasculature, where they regulate potassium and water transport.	Water	130-135	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	16-22
18216318-3	2008	Gene array analysis revealed that these findings were associated with significant downregulation of water channels (aquaporin-1, -2, -3, and -4) and transporters of sodium, glucose, urea, and other solutes.	Water	100-105	aquaporin 1	Rattus norvegicus	116-143
17683891-4	2008	On the other hand, in a nuclear magnetic resonance experiment, the relaxation rates of protein solutions (1/T1 and 1/T2) and also those of free water (1/T1f and 1/T2f) are measurable.	Water	144-149	interleukin 1 receptor like 1	Homo sapiens	153-162
25015800-6	2014	Although passive bidirectional movements of water and solutes occur across the intramembranous pathway, intramembranous absorption is primarily a unidirectional, vesicular, bulk transport process mediated through VEGF activation of transcytotic transport via caveolae.	Water	44-49	vascular endothelial growth factor A	Ovis aries	213-217
20200594-5	2008	Results showed that the PLN cell proliferation of mice treated with anti-CTLA-4 mAb and IL-18 remained significantly suppressed compared with water-fed controls, while a partial abrogation of suppressed IL-4 and IFN-gamma levels were observed.	Water	142-147	interleukin 18	Mus musculus	88-93
25338424-4	2014	We hypothesized that during crystalloid-induced osmosis, the osmotic water flux through the transendothelial water-exclusive aquaporin 1 (AQP1) channels is the primary mechanism whereby the endothelium is being stimulated to instigate hyperosmolality-driven vasodilation.	Water	69-74	aquaporin 1	Rattus norvegicus	125-136
18329285-6	2008	In conclusion, activation of TRPV1 in the isolated kidney decreases renal PP and increases GFR and water/sodium excretion possibly via simultaneous activation of CGRP and SP receptors upon their enhanced release, suggesting that TRPV1 plays a key role in modulating renal hemodynamics and excretory function.	Water	99-104	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	29-34
18329285-6	2008	In conclusion, activation of TRPV1 in the isolated kidney decreases renal PP and increases GFR and water/sodium excretion possibly via simultaneous activation of CGRP and SP receptors upon their enhanced release, suggesting that TRPV1 plays a key role in modulating renal hemodynamics and excretory function.	Water	99-104	calcitonin-related polypeptide alpha	Rattus norvegicus	162-166
18329285-6	2008	In conclusion, activation of TRPV1 in the isolated kidney decreases renal PP and increases GFR and water/sodium excretion possibly via simultaneous activation of CGRP and SP receptors upon their enhanced release, suggesting that TRPV1 plays a key role in modulating renal hemodynamics and excretory function.	Water	99-104	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	229-234
18160533-7	2008	The effects of drinking were examined by correlating volume of water drunk with changes in ROI rCBF from maximum thirst to postdrinking.	Water	63-68	CCAAT/enhancer binding protein zeta	Rattus norvegicus	95-99
17941896-4	2008	In the present study, we investigated the expression of the AQP1 water channel in cultured articular chondrocytes from wild-type (AQP1(+/+)) and AQP1-knockout (AQP1(-/-)) mice and characterized its function in chondrocyte proliferation, migration and adhesion.	Water	65-70	aquaporin 1	Mus musculus	60-64
17941896-4	2008	In the present study, we investigated the expression of the AQP1 water channel in cultured articular chondrocytes from wild-type (AQP1(+/+)) and AQP1-knockout (AQP1(-/-)) mice and characterized its function in chondrocyte proliferation, migration and adhesion.	Water	65-70	aquaporin 1	Mus musculus	130-134
17941896-4	2008	In the present study, we investigated the expression of the AQP1 water channel in cultured articular chondrocytes from wild-type (AQP1(+/+)) and AQP1-knockout (AQP1(-/-)) mice and characterized its function in chondrocyte proliferation, migration and adhesion.	Water	65-70	aquaporin 1	Mus musculus	130-134
17941896-4	2008	In the present study, we investigated the expression of the AQP1 water channel in cultured articular chondrocytes from wild-type (AQP1(+/+)) and AQP1-knockout (AQP1(-/-)) mice and characterized its function in chondrocyte proliferation, migration and adhesion.	Water	65-70	aquaporin 1	Mus musculus	130-134
18199454-9	2008	The reduction in diffusion coefficient is likely to due to structural changes in the AS-1 and AS-2 helices such that hydrogen bonding with the surrounding water molecules is increased, thereby increasing friction with the solvent.	Water	155-160	prostaglandin D2 receptor	Homo sapiens	85-89
25338424-4	2014	We hypothesized that during crystalloid-induced osmosis, the osmotic water flux through the transendothelial water-exclusive aquaporin 1 (AQP1) channels is the primary mechanism whereby the endothelium is being stimulated to instigate hyperosmolality-driven vasodilation.	Water	69-74	aquaporin 1	Rattus norvegicus	138-142
17957752-8	2007	Thus, AQP9 is abundantly expressed in dog male reproductive tract, in which it is an important apical pathway for transmembrane flow of water and neutral solutes.	Water	136-141	aquaporin 9	Canis lupus familiaris	6-10
25338424-4	2014	We hypothesized that during crystalloid-induced osmosis, the osmotic water flux through the transendothelial water-exclusive aquaporin 1 (AQP1) channels is the primary mechanism whereby the endothelium is being stimulated to instigate hyperosmolality-driven vasodilation.	Water	109-114	aquaporin 1	Rattus norvegicus	125-136
18270608-1	2008	Recombination events of a proton with NO3- at (H2O)8 clusters are studied by molecular dynamics, using "on-the-fly" reliable ab initio MP2 potentials.	Water	47-50	Serine protease 7	Drosophila melanogaster	135-138
25338424-4	2014	We hypothesized that during crystalloid-induced osmosis, the osmotic water flux through the transendothelial water-exclusive aquaporin 1 (AQP1) channels is the primary mechanism whereby the endothelium is being stimulated to instigate hyperosmolality-driven vasodilation.	Water	109-114	aquaporin 1	Rattus norvegicus	138-142
25338424-11	2014	We conclude that the peritoneal microvascular vasodilation caused by hyperosmolar PD fluid is instigated by the osmotic water flux through AQP1.	Water	120-125	aquaporin 1	Rattus norvegicus	139-143
25504362-7	2014	Polymorphisms of eleven genes have been associated with stones in genome-wide association studies and replicated candidate-gene association studies: VDR, SLC34A1, SLC34A4, CLDN14, and CaSR genes coding for proteins regulating tubular phosphate and calcium reabsorption; CaSR, MGP, OPN, PLAU, and UMOD genes coding for proteins preventing calcium salt precipitation; AQP1 gene coding for a water channel in the proximal tubule.	Water	389-394	solute carrier family 34 member 1	Homo sapiens	154-161
18305423-0	2008	Synthesis and properties of a new water-soluble prodrug of the adenosine A 2A receptor antagonist MSX-2.	Water	34-39	adenosine A2a receptor	Sus scrofa	63-86
18070239-1	2008	Aquaporin-1 (AQP-1), a six-transmembrane domain protein, is found to be responsible for water transport.	Water	88-93	aquaporin 1	Mus musculus	0-11
18186335-2	2007	The DGT-CID technique precipitates and immobilizes the net pore-water flux of dissolved sulfide as black Ag2S by reaction with a AgI binding gel.	Water	64-69	angiotensin II receptor type 1	Homo sapiens	105-109
18158997-1	2007	OBJECTIVE: To provide insights into the mechanisms and pathways of osteogensis by observing the effects of water-soluble matrix of nacre (WSM) on bone morphogenetic protein-2 (BMP-2) and Cbfa1 gene expressions in rabbit marrow mesenchymal stem cells (BMSCs).	Water	107-112	bone morphogenetic protein 2	Oryctolagus cuniculus	146-174
18158997-1	2007	OBJECTIVE: To provide insights into the mechanisms and pathways of osteogensis by observing the effects of water-soluble matrix of nacre (WSM) on bone morphogenetic protein-2 (BMP-2) and Cbfa1 gene expressions in rabbit marrow mesenchymal stem cells (BMSCs).	Water	107-112	bone morphogenetic protein 2	Oryctolagus cuniculus	176-181
18070239-1	2008	Aquaporin-1 (AQP-1), a six-transmembrane domain protein, is found to be responsible for water transport.	Water	88-93	aquaporin 1	Mus musculus	13-18
24046257-5	2014	Molecular dynamics revealed that myricetin interacts in its stretched conformation through water-mediated interactions with C-terminal of MGAM and by normal hydrogen bonding with the N-terminal.	Water	91-96	maltase-glucoamylase	Homo sapiens	138-142
18070239-7	2008	These findings provide valuable information on the expression of AQP-1 in male reproductive organs and suggest that AQP-1 is involved in water transport to regulate water homeostasis in male reproductive physiology.	Water	137-142	aquaporin 1	Mus musculus	116-121
18239299-8	2008	The in vivo testing in normal mice and diabetic mice suggest that this zinc-stabilized technique combined with S/O/O method in the presence of water insoluble antacid additive ZnCO(3) preserve the biological activity of GLP-1.	Water	143-148	glucagon	Mus musculus	220-225
17658579-3	2007	This paper describes a sampling campaign designed to track changes in water quality in a surface water system in Vientiane (Lao PDR) receiving significant quantities of untreated waste water.	Water	70-75	interleukin 4 induced 1	Homo sapiens	124-127
17658579-3	2007	This paper describes a sampling campaign designed to track changes in water quality in a surface water system in Vientiane (Lao PDR) receiving significant quantities of untreated waste water.	Water	97-102	interleukin 4 induced 1	Homo sapiens	124-127
24148241-5	2014	To express deviation from ideal partitioning, we define an enhancement or exclusion factor, E   k/phi1, where phi1 is hydrogel water volume fraction.	Water	127-132	protein phosphatase 1 regulatory inhibitor subunit 14B	Homo sapiens	98-102
18349501-3	2007	It is of particular importance to photosynthetic organisms in the chloroplast of which a cluster of Mn atoms at the catalytic centre function in the light-induced water oxidation by photosystem II, and also function as a cofactor for a variety of enzymes, such as Mn-SOD.	Water	163-168	superoxide dismutase 2	Homo sapiens	264-270
18042646-1	2008	CONTEXT: Dual oxidase 2 (DUOX2) is the catalytic core of the H(2)O(2) generator crucial for the iodination of thyroglobulin in thyroid hormone synthesis.	Water	61-66	thyroglobulin	Homo sapiens	110-123
24148241-5	2014	To express deviation from ideal partitioning, we define an enhancement or exclusion factor, E   k/phi1, where phi1 is hydrogel water volume fraction.	Water	127-132	protein phosphatase 1 regulatory inhibitor subunit 14B	Homo sapiens	110-114
17936362-9	2008	Thus, the time keeping oscillations of ECTO-NOX proteins appear to reflect the equilibrium dynamics of ortho-para hydrogen atom spin ratios of water where the presence of metal cations such as Cu(II) in solution determine period length.	Water	143-148	tripartite motif containing 33	Homo sapiens	39-43
25322648-5	2014	It is concluded that renin-angiotensin system (RAS) of renal tissues is involved in the mechanism of dopamine action in the kidney, acting as a modulator that prevents excessive loss of water and electrolytes with urine.	Water	186-191	renin	Rattus norvegicus	21-26
18549190-0	2008	[An exemple of artificial mineral water : famous "Lithines du Dr Gustin"].	Water	34-39	carbonic anhydrase 6	Homo sapiens	65-71
17699554-1	2007	The canonical transient receptor potential channels TRPC3 and TRPC6 are abundantly expressed along with the water channel aquaporin-2 (AQP2) in principal cells of the cortical and medullary collecting duct.	Water	108-113	transient receptor potential cation channel, subfamily C, member 3	Rattus norvegicus	52-57
23962074-2	2014	Aquaporin 1 (Aqp1) is a water channel molecule and a regulator of endothelial cell migration.	Water	24-29	aquaporin 1	Rattus norvegicus	0-11
17855494-4	2007	In the first experiment, soft water-acclimated zebrafish were exposed to 8 and 15 mug/l Cu for 48 h. This exposure resulted in significant increases in gene expression of cytochrome c oxidase subunit 17 (COX-17) and catalase, associated with both increased Cu load and protein carbonyl concentrations in the gill and liver after 48 h. In addition, we examined the potential protective effects of increased waterborne Ca(2+) (3.3 mM) and Na(+) (10 mM) on acute Cu toxicity.	Water	30-35	cytochrome c oxidase copper chaperone COX17	Danio rerio	204-210
18048366-6	2008	The hypothesis that Sln1p kinase activity is responsive to turgor was first suggested by the increased Sln1p kinase activity in mutants lacking Fps1p in which glycerol accumulation leads to water uptake.	Water	190-195	histidine kinase	Saccharomyces cerevisiae S288C	20-25
23962074-2	2014	Aquaporin 1 (Aqp1) is a water channel molecule and a regulator of endothelial cell migration.	Water	24-29	aquaporin 1	Rattus norvegicus	13-17
17656054-1	2008	The composition comprising the highly water-soluble drug meglumine antimoniate (MA) and beta-cyclodextrin (beta-CD) was shown previously to enhance the absorption of Sb by oral route and render MA orally active in a murine model of cutaneous leishmaniasis.	Water	38-43	beta-carotene oxygenase 1	Mus musculus	107-114
17927670-4	2007	Microarray studies on mRNAs differentially expressed in the SON revealed that transcripts encoding the Ywhag and Ywhaz isoforms of the 14-3-3 family of regulatory proteins, are increased in the rat SON by 3 days of water deprivation; findings that we have confirmed by the real-time polymerase chain reaction.	Water	215-220	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma	Rattus norvegicus	103-108
24376702-0	2013	Biophysical assessment of human aquaporin-7 as a water and glycerol channel in 3T3-L1 adipocytes.	Water	49-54	aquaporin 7	Homo sapiens	32-43
17959724-3	2008	We have shown previously that a BBB Na-K-Cl cotransporter (NKCC) participates in ischemia-induced brain Na and water uptake and that a BBB Na/H exchanger (NHE) may also participate.	Water	111-116	solute carrier family 9 member C1	Homo sapiens	139-153
17959724-3	2008	We have shown previously that a BBB Na-K-Cl cotransporter (NKCC) participates in ischemia-induced brain Na and water uptake and that a BBB Na/H exchanger (NHE) may also participate.	Water	111-116	solute carrier family 9 member C1	Homo sapiens	155-158
18399524-6	2008	Although the [Ag(eth-hex-en)(2)]NO(3) liquid is sparingly soluble in bulk water, it readily incorporates a small amount of water up to [water]/[metal complex] = 7:1.	Water	123-128	hematopoietically expressed homeobox	Homo sapiens	21-24
24376702-3	2013	Based on this situation, we have re-assessed the precise localization of AQP7 in adipose tissue and analyzed its function as a water and/or glycerol channel in adipose cells.	Water	127-132	aquaporin 7	Homo sapiens	73-77
18399524-6	2008	Although the [Ag(eth-hex-en)(2)]NO(3) liquid is sparingly soluble in bulk water, it readily incorporates a small amount of water up to [water]/[metal complex] = 7:1.	Water	123-128	hematopoietically expressed homeobox	Homo sapiens	21-24
18075463-2	2007	An evidence exists that PTK2B is involved in cell growth, vascular contraction, inflammatory responses, and salt and water retention through activation of the angiotensin II type 1 receptor.	Water	117-122	angiotensin II receptor type 1	Homo sapiens	159-189
24376702-6	2013	By overexpressing the human AQP7 in 3T3-L1 adipocytes it was possible to ascertain its role as a water and glycerol channel in a gain-of-function scenario.	Water	97-102	aquaporin 7	Homo sapiens	28-32
24376702-8	2013	Furthermore it is also reported for the first time a negative correlation between water permeability and the cell non-osmotic volume supporting the observation that AQP7 depleted cells are more prone to lipid accumulation.	Water	82-87	aquaporin 7	Homo sapiens	165-169
24376702-9	2013	Additionally, the strong positive correlation between the rates of water and glycerol transport highlights the role of AQP7 as both a water and a glycerol channel and reflects its expression levels in cells.	Water	67-72	aquaporin 7	Homo sapiens	119-123
24376702-9	2013	Additionally, the strong positive correlation between the rates of water and glycerol transport highlights the role of AQP7 as both a water and a glycerol channel and reflects its expression levels in cells.	Water	134-139	aquaporin 7	Homo sapiens	119-123
24376702-10	2013	In all, our results clearly document a direct involvement of AQP7 in water and glycerol transport, as well as in triglyceride content in adipocytes.	Water	69-74	aquaporin 7	Homo sapiens	61-65
23962357-2	2013	When immersed in water, an ionic mica plate initially covered by a monolayer of surfactants rearranges to a surface inhomogeneously covered by patches of surfactant bilayer and bare mica.	Water	17-22	MHC class I polypeptide-related sequence A	Homo sapiens	33-37
17949486-6	2007	We used a high-speed intravenous injection of naked plasmid DNA of transforming growth factor-beta1 (TGF-beta1) gene which is under the control of a metallothionein-regulated gene in a pPK9A expression vector into the tail vein (the hydrodynamics-based transfer) and fed the mouse with zinc sulfate (ZnSO4)-containing water simultaneously.	Water	318-323	transforming growth factor, beta 1	Mus musculus	67-99
17949486-6	2007	We used a high-speed intravenous injection of naked plasmid DNA of transforming growth factor-beta1 (TGF-beta1) gene which is under the control of a metallothionein-regulated gene in a pPK9A expression vector into the tail vein (the hydrodynamics-based transfer) and fed the mouse with zinc sulfate (ZnSO4)-containing water simultaneously.	Water	318-323	transforming growth factor, beta 1	Mus musculus	101-110
23962357-2	2013	When immersed in water, an ionic mica plate initially covered by a monolayer of surfactants rearranges to a surface inhomogeneously covered by patches of surfactant bilayer and bare mica.	Water	17-22	MHC class I polypeptide-related sequence A	Homo sapiens	182-186
23962357-7	2013	We observe that when this interaction is absent, the system undergoes phase separation into a bilayer phase and mica surface covered with water.	Water	138-143	MHC class I polypeptide-related sequence A	Homo sapiens	112-116
17693485-6	2007	Extravascular lung water was significantly increased after alphaENaC silencing and reduced after Nedd4-2 silencing.	Water	19-24	NEDD4 like E3 ubiquitin protein ligase	Rattus norvegicus	97-104
23842942-9	2013	Water soluble fraction of G. sylvestre ethanolic extract and rimonabant significantly reduced serum lipids, leptin, insulin, glucose, apolipoprotein B and LDH levels while it significantly increased the HDL-cholesterol, apolipoprotein A1 and antioxidant enzymes levels in liver tissue as compared to the HFD fed rats.	Water	0-5	leptin	Rattus norvegicus	108-114
17898307-1	2007	PURPOSE: Aquaporin-1 (AQP1) water channels are expressed widely in organ and tumor microvascular endothelia.	Water	28-33	aquaporin 1	Mus musculus	9-20
17898307-1	2007	PURPOSE: Aquaporin-1 (AQP1) water channels are expressed widely in organ and tumor microvascular endothelia.	Water	28-33	aquaporin 1	Mus musculus	22-26
24253616-0	2013	Oral "hydrogen water" induces neuroprotective ghrelin secretion in mice.	Water	15-20	ghrelin	Mus musculus	46-53
17902839-5	2007	Rabbits were anesthetized and a water tight reservoir that held the insulin was fastened on the rabbit"s thigh.	Water	32-37	insulin	Oryctolagus cuniculus	68-75
23813972-6	2013	hCNT3-expressing cells swelled no faster than control cells, whereas SLC4A11-mediated water permeation at a rate about half that of some AQP proteins.	Water	86-91	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Mus musculus	69-76
17985666-7	2007	Although a MBP layer in conjunction with water-consumptive trees can reduce vertical water losses as compared to mineral substrates, the effect is not sufficient to meet legal regulations.	Water	85-90	myelin basic protein	Homo sapiens	11-14
23813972-9	2013	Slc4a11(-/-) mice manifest corneal oedema and distorted endothelial cells, consistent with loss of a water-flux.	Water	101-106	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Mus musculus	0-7
17724204-8	2007	This novel mechanism of regulating Cx43 most likely plays an important role in maintaining the microcirculation that is essential for the movement of water and solutes in the intact lens.	Water	150-155	gap junction protein alpha 1	Homo sapiens	35-39
23829545-7	2013	DISCUSSION: Diluted hydrofluoric acid is present in aqueous solution of SnF2 and TiF4 (which are known to inhibit dental erosion): SnF2 + 3H2O = Sn(OH)2 + 2HF + H2O and TiF4 + 5H2O = Ti(OH)4 + 4HF + H2O.	Water	139-142	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	72-76
24192186-2	2013	The coordination environment of each pentacoordinated Cu(II) centre is square pyramidal (SBP), formed by three water molecules and two carboxylate O atoms from two different (btec)(4-) ligands.	Water	111-116	selenium binding protein 1	Homo sapiens	89-92
17257750-0	2007	Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons.	Water	53-58	aquaporin 1	Mus musculus	38-49
17257750-1	2007	Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues.	Water	59-64	aquaporin 1	Mus musculus	0-11
17257750-1	2007	Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues.	Water	59-64	aquaporin 1	Mus musculus	13-17
24014685-3	2013	Analysis of BrdU incorporation during long-term feeding and during chasing (delabeling) following replacement of BrdU-water with normal water shows that the CD45(neg)CD31(neg)Sca-1(pos) lung mesenchymal stromal cell compartment turns over at a rate of ~2.26% per day with a time to half-cycled of 44 days, an estimated cell proliferation rate of 0.004/day, and a cell death rate of 0.018/day.	Water	118-123	platelet/endothelial cell adhesion molecule 1	Mus musculus	166-170
17622954-3	2007	In HepG2 cells, stigmasterol acetate (StigAc), a water-soluble Stig derivative, suppressed ligand-activated expression of FXR target genes involved in adaptation to cholestasis (i.e. BSEP, FGF-19, OSTalpha/beta).	Water	49-54	nuclear receptor subfamily 1 group H member 4	Homo sapiens	122-125
24014685-3	2013	Analysis of BrdU incorporation during long-term feeding and during chasing (delabeling) following replacement of BrdU-water with normal water shows that the CD45(neg)CD31(neg)Sca-1(pos) lung mesenchymal stromal cell compartment turns over at a rate of ~2.26% per day with a time to half-cycled of 44 days, an estimated cell proliferation rate of 0.004/day, and a cell death rate of 0.018/day.	Water	136-141	platelet/endothelial cell adhesion molecule 1	Mus musculus	166-170
24073894-2	2013	Interestingly, there are two spectrally distinct hydrogen-bond (H-bond) configurations in aqueous NaPF6 solutions: water molecules that are H-bonded to PF6(-) (ODA) or other water molecules (ODW).	Water	115-120	sperm associated antigen 17	Homo sapiens	100-103
17475620-7	2007	A water molecule is observed near TTQ C-6 and is likely derived from the collapse of the preceding carbinolamine TTQ-adduct.	Water	2-7	complement C6	Homo sapiens	38-41
24073894-5	2013	In aqueous 5.0 M NaPF6 solution, water molecules switch their H-bond partners from PF6(-) to water molecule (ODA   ODW) with a time constant of 12.0 ps and from water molecule to PF6(-) (ODW   ODA) with a time constant of 21.6 ps at room temperature.	Water	33-38	sperm associated antigen 17	Homo sapiens	19-22
24073894-5	2013	In aqueous 5.0 M NaPF6 solution, water molecules switch their H-bond partners from PF6(-) to water molecule (ODA   ODW) with a time constant of 12.0 ps and from water molecule to PF6(-) (ODW   ODA) with a time constant of 21.6 ps at room temperature.	Water	33-38	sperm associated antigen 17	Homo sapiens	83-86
24073894-5	2013	In aqueous 5.0 M NaPF6 solution, water molecules switch their H-bond partners from PF6(-) to water molecule (ODA   ODW) with a time constant of 12.0 ps and from water molecule to PF6(-) (ODW   ODA) with a time constant of 21.6 ps at room temperature.	Water	93-98	sperm associated antigen 17	Homo sapiens	19-22
17049977-3	2007	METHODS: HGF were grown in 96-well plates for 24h, treated with various concentrations of TEGDMA (0.5-5.0mM) for 24h and subsequently for 90min with 0.2mM H(2)O(2) or culture medium (control).	Water	155-160	hepatocyte growth factor	Homo sapiens	9-12
24073894-5	2013	In aqueous 5.0 M NaPF6 solution, water molecules switch their H-bond partners from PF6(-) to water molecule (ODA   ODW) with a time constant of 12.0 ps and from water molecule to PF6(-) (ODW   ODA) with a time constant of 21.6 ps at room temperature.	Water	93-98	sperm associated antigen 17	Homo sapiens	19-22
24205219-3	2013	IL-1 plays a key role in inflammation-induced sickness behaviour, resulting in depressed locomotor activity, decreased exploration, reduced food and water intake and acute cognitive deficits.	Water	149-154	interleukin 1 complex	Mus musculus	0-4
17219420-8	2007	Significantly, lower blastocyst development was observed in E-cadherin and water-injected embryos following in vivo culture compared to the noninjected controls, while intermediate results were obtained following injection with Cx43 dsRNA.	Water	75-80	gap junction protein alpha 1	Bos taurus	228-232
24073915-2	2013	Meanwhile, replacement of sodium ion with an ammonium amphiphile 1 gives a lipid complex 1[Eu(nta)4] which shows distinct changes: its luminescence quantum yield Phi is remarkably increased to ~0.6 above the water content of ~60 vol.	Water	208-213	glucose-6-phosphate isomerase	Homo sapiens	162-165
17468165-0	2007	Molecular dynamics simulation of deoxy and carboxy murine neuroglobin in water.	Water	73-78	neuroglobin	Mus musculus	58-69
17468165-7	2007	We report the results of extended (90 ns) molecular dynamics simulations in water of ferrous deoxy and carboxy murine neuroglobin, which are both coordinated on the distal site, in the latter case by CO and in the former one by the distal His(64)(E7).	Water	76-81	neuroglobin	Mus musculus	118-129
23989288-0	2013	Progress towards water-soluble triazole-based selective MMP-2 inhibitors.	Water	17-22	matrix metallopeptidase 2	Homo sapiens	56-61
17553469-3	2007	The present study examined the immunolocalization of aquaporin-1 (AQP1) and -4 (AQP4), a member of the water-selective channel, in the periodontal Ruffini endings of the rat incisors and trigeminal ganglion.	Water	103-108	aquaporin 1	Rattus norvegicus	53-78
17553469-11	2007	These findings suggest that AQP1 controls water transport in the periodontal Ruffini endings.	Water	42-47	aquaporin 1	Rattus norvegicus	28-32
23989288-2	2013	In an effort to improve the water solubility of our recently reported nanomolar matrix metalloproteinase type 2 (MMP-2) inhibitors based on triazole-substituted hydroxamates, we synthesized a new series of alpha-sulfone, alpha-tetrahydropyran and alpha-piperidine, alpha-sulfone clicked hydroxamates and determined their inhibitory activities against both MMP-2 and MMP-9.	Water	28-33	matrix metallopeptidase 2	Homo sapiens	80-111
23989288-3	2013	The best results were found for 13e, a water-soluble compound that displays a low nanomolar activity against MMP-2 and is 26-fold less active against MMP-9.	Water	39-44	matrix metallopeptidase 2	Homo sapiens	109-114
23831422-6	2013	In human subjects, two-alternative forced choice (2-AFC) tests, triangle tests and sensory profiling showed that non fatty acid agonists of GPR40 dissolved in water are detected in sip and spit tests and elicit a taste similar to that of linoleic acid, whereas 2-AFC tests showed that two agonists of GPR120 in water are not perceived fattier than water alone.	Water	159-164	free fatty acid receptor 4	Homo sapiens	301-307
17532793-0	2007	Identification of central nervous system sites involved in the water diuresis response elicited by central microinjection of nociceptin/ Orphanin FQ in conscious rats via c-Fos and inducible cAMP early repressor immunocytochemistry.	Water	63-68	cAMP responsive element modulator	Rattus norvegicus	181-211
19128227-1	2008	Aldosterone is a steroid hormone that controls blood pressure by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor, and regulating genes that play a role in salt and water homeostasis in the kidney.	Water	204-209	nuclear receptor subfamily 3 group C member 2	Homo sapiens	80-106
19128227-1	2008	Aldosterone is a steroid hormone that controls blood pressure by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor, and regulating genes that play a role in salt and water homeostasis in the kidney.	Water	204-209	nuclear receptor subfamily 3 group C member 2	Homo sapiens	108-110
17548598-8	2007	Bet.-APE significantly and dose-dependently enhanced intracellular cAMP, suggesting that water-soluble factors from pollen grains bind a G(alphas)-protein-coupled receptor.	Water	89-94	delta/notch like EGF repeat containing	Homo sapiens	0-3
24021113-5	2013	We performed molecular dynamics simulations of the AmtB and RhCG proteins under different water and ammonia occupancy states of their pore.	Water	90-95	Rh family C glycoprotein	Homo sapiens	60-64
18237495-4	2008	The electrospun PVP/PLCL membranes showed the largest water absorption (501.3%) in phosphate buffer solution due to introduction of the PVP component and the core/shell fiber structure.	Water	54-59	phospholipase C like 1 (inactive)	Homo sapiens	20-24
23978402-5	2013	Acute AT1 blockade induced a significant reduction in the MAP in the OVX rats, resulting in increased HR and water intake, which were attenuated by estradiol therapy.	Water	109-114	angiotensin II receptor, type 1a	Rattus norvegicus	6-9
18022750-6	2008	RESULTS: Demineralised dentine saturated with water showed a Td of 65.6 degrees C that increased with saturation by methanol, ethanol, acetone, eta-butanol or HEMA to 148.5 degrees C. These increases in Td were inversely related to the molar concentration of the solvents and to their Hoy"s solubility parameter for hydrogen bonding (delta h, p&lt;0.01), as well as directly related to the cube root of their molecular weights (p&lt;0.001).	Water	46-51	endothelin receptor type A	Homo sapiens	144-147
23274807-0	2013	Temporal variation and spatial distribution of PAH in water of Three Gorges Reservoir during the complete impoundment period.	Water	54-59	phenylalanine hydroxylase	Homo sapiens	47-50
18781058-0	2008	Acceleration of lipid peroxidation in alpha-tocopherol transfer protein-knockout mice following the consumption of drinking water containing a radical initiator.	Water	124-129	tocopherol (alpha) transfer protein	Mus musculus	38-71
17435993-2	2007	The prepared luminescent water-soluble CdS QDs were evaluated as fluorescence probes for the detection of highly reactive hydrogen selenide ions (HSe(-) ions).	Water	25-30	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	146-149
23274807-2	2013	PAH concentrations in water of TGR in the period of completely impounding water were 15-381 ng L(-1).	Water	22-27	phenylalanine hydroxylase	Homo sapiens	0-3
17405146-7	2007	We also demonstrate that p34 (a component of the Arp2/3 complex), WASP/WAVE proteins, actin, alpha-tubulin, Rac, Cdc42, vinculin, and focal adhesion kinase are detected in water-shocked myelin purified from brain.	Water	172-177	alpha and gamma adaptin binding protein	Homo sapiens	25-28
19192719-1	2008	The properties and effects of neutral pH hydrogen-enriched electrolyzed water (NHE water) on tumor cells were examined.	Water	72-77	solute carrier family 9 member C1	Homo sapiens	79-82
17405146-7	2007	We also demonstrate that p34 (a component of the Arp2/3 complex), WASP/WAVE proteins, actin, alpha-tubulin, Rac, Cdc42, vinculin, and focal adhesion kinase are detected in water-shocked myelin purified from brain.	Water	172-177	cell division cycle 42	Homo sapiens	113-118
23274807-2	2013	PAH concentrations in water of TGR in the period of completely impounding water were 15-381 ng L(-1).	Water	74-79	phenylalanine hydroxylase	Homo sapiens	0-3
17405146-7	2007	We also demonstrate that p34 (a component of the Arp2/3 complex), WASP/WAVE proteins, actin, alpha-tubulin, Rac, Cdc42, vinculin, and focal adhesion kinase are detected in water-shocked myelin purified from brain.	Water	172-177	vinculin	Homo sapiens	120-128
19192719-2	2008	NHE water diminished hydroxyl radicals as demonstrated by ESR in a cell-free system.	Water	4-9	solute carrier family 9 member C1	Homo sapiens	0-3
23274807-5	2013	An obvious decrease of PAH concentration was observed after 175-m water impounding in 2011 in TGR.	Water	66-71	phenylalanine hydroxylase	Homo sapiens	23-26
19192719-3	2008	Human tongue carcinoma cells HSC-4 were inhibited for either colony formation efficiencies or colony sizes by NHE water without significant inhibition to normal human tongue epithelial-like cells DOK.	Water	114-119	solute carrier family 9 member C1	Homo sapiens	110-113
19192719-4	2008	Furthermore, NHE water caused growth inhibition, cell degeneration, and inhibition of invasion through the reconstituted basement membrane to human fibrosarcoma cells HT-1080.	Water	17-22	solute carrier family 9 member C1	Homo sapiens	13-16
23274807-7	2013	Passive sampling method has been successfully applied in the investigation of trace PAH in water of TGR and proved to be a useful and efficient tool for the management and sustainable development of the big reservoir.	Water	91-96	phenylalanine hydroxylase	Homo sapiens	84-87
19192719-5	2008	Intracellular oxidants such as hydroperoxides and hydrogen peroxides were scavenged in HSC-4 or HT-1080 cells by NHE water.	Water	117-122	solute carrier family 9 member C1	Homo sapiens	113-116
23721933-15	2013	NSE was significantly increased post injury in the H2O/TBI group compared with H2O/Sham but was not significantly reduced by EtOH pretreatment.	Water	51-54	enolase 2, gamma neuronal	Mus musculus	0-3
19192719-6	2008	In the human oral cavity, a dissolved hydrogen concentrations (DH) of NHE water was drastically declined from 1.1 to 0.5 ppm, but settled to 0.3-0.4 ppm until 180 s, upon static holding without gargling.	Water	74-79	solute carrier family 9 member C1	Homo sapiens	70-73
19192719-7	2008	Thus, NHE water was shown to achieve tumor-preferential growth inhibition and tumor invasion together with scavenging of intracellular oxidants, and is expected as a preventive material against tumor progression and invasion.	Water	10-15	solute carrier family 9 member C1	Homo sapiens	6-9
18173719-2	2008	The resulting water-soluble octadiazopyruvoyl PAMAM (8G.1 DAP, 1.3) was shown to undergo Wolff rearrangements upon photolysis in methanol at lambda &gt; 300 nm to yield the methyl esters of the ketenes formed from the loss of nitrogen.	Water	14-19	death associated protein	Homo sapiens	58-61
17562468-4	2007	LA and LG activities alone and their ratio with organic-C (ratio index value, RIV), straw and grain yield were higher in DCM than MSWC-treated soils, due to higher amount of biogenic organic materials like water-soluble organic carbon, carbohydrate and mineralizable nitrogen in the former.	Water	206-211	asparaginase and isoaspartyl peptidase 1	Bos taurus	0-2
17325454-2	2007	Aquaporin-3 is a water/solute channel that can transport not only water but also various cryoprotectants.	Water	17-22	aquaporin 3a	Danio rerio	0-11
23721933-15	2013	NSE was significantly increased post injury in the H2O/TBI group compared with H2O/Sham but was not significantly reduced by EtOH pretreatment.	Water	79-82	enolase 2, gamma neuronal	Mus musculus	0-3
17325454-2	2007	Aquaporin-3 is a water/solute channel that can transport not only water but also various cryoprotectants.	Water	66-71	aquaporin 3a	Danio rerio	0-11
17325454-6	2007	Thus, the permeability of immature zebrafish oocytes to water and cryoprotectants was enhanced by exogenous expression of aquaporin-3.	Water	56-61	aquaporin 3a	Danio rerio	122-133
24288995-7	2013	To some extent, higher eta and lower B value was favorable for the improvement of coagulation performance for coagulation treatment of both synthetic dyeing wastewater and simulated ground water.	Water	162-167	endothelin receptor type A	Homo sapiens	23-26
17293041-1	2007	Electrolytic transformation of benzene in water is evaluated as a potential mechanism that can be implemented for in situ remediation of benzene in groundwater.	Water	42-47	myelin and lymphocyte protein, T cell differentiation protein	Mus musculus	15-16
23184731-1	2013	Among the compensatory mechanisms restoring circulating blood volume after severe haemorrhage, increased vasopressin secretion enhances water permeability of distal nephron segments and stimulates Na(+) reabsorption in cortical collecting tubules via epithelial sodium channels (ENaC).	Water	136-141	arginine vasopressin S homeolog	Xenopus laevis	105-116
23990758-6	2013	The CE1/5 profiles supply the water geochemical and geophysical data by their better accuracy.	Water	30-35	carboxylesterase 1	Homo sapiens	4-9
17439165-3	2007	Once SA1 is completed, the hydrophobic BD-QD building blocks are blended with amphiphilic block copolymer stabilizing chains in an organic solvent; water addition induces secondary self-assembly (SA2) to form quantum dot compound micelles (QDCMs).	Water	148-153	stromal antigen 2	Homo sapiens	196-199
23714076-2	2013	Intracerebroventricular (icv) injections of Nes-1 reduce water intake, although the sites of action for this effect are not known.	Water	57-62	nucleobindin 2	Rattus norvegicus	44-49
17425297-3	2007	X-ray crystal structures of complexes of nNOS with two nNOS-selective inhibitors, (4S)-N-{4-amino-5-[(2-aminoethylamino]pentyl}-N"-nitroguanidine (1) and 4-N-(Nomega-nitro-l-argininyl)-trans-4-amino-l-proline amide (2), led to the discovery of a conserved structural water molecule that was hydrogen bonded between the two heme propionates and the inhibitors (Figure 2).	Water	267-272	nitric oxide synthase 1	Homo sapiens	41-45
17425297-6	2007	X-ray crystal structures of nNOS with inhibitors 3 and 5 bound verified that the N-hydroxyl group had, indeed, displaced the structural water molecule and provided a direct interaction with the heme propionate moiety (Figures 5 and 6).	Water	136-141	nitric oxide synthase 1	Homo sapiens	28-32
23714076-7	2013	As SFO is a pivotal central site in the regulation of water intake, a second series of experiments was done to investigate the role of direct injections of Nes-1 into SFO on water intake in conscious, freely moving rats.	Water	174-179	nucleobindin 2	Rattus norvegicus	156-161
23714076-8	2013	Nes-1 (2pmol) injections into SFO induced an increase in water intake compared to vehicle injections.	Water	57-62	nucleobindin 2	Rattus norvegicus	0-5
17438497-11	2007	This study demonstrated that cool running water appeared the most effective first aid for an acute scald burn wound in a porcine model compared with wet towels and water spray.	Water	42-47	activation induced cytidine deaminase	Homo sapiens	82-85
23680844-13	2013	The positive selection on LRRs in TLR9s of Perciformes might be associated with the adaptation to the rapidly evolving pathogens in the water.	Water	136-141	toll like receptor 9	Homo sapiens	34-38
17378553-6	2007	These studies indicated that the copper center in the CuL1 complex adopts a square-pyramidal geometry with the four nitrogen atoms of the macrocycle forming the equatorial plane and a water molecule at axial position, and the copper in the CuL2 complex is square-planar.	Water	184-189	cullin 1	Homo sapiens	54-58
23624428-1	2013	This work describes the efficiency of photoelectrocatalysis based on Ti/TiO2 nanotubes in the degradation of the azo dyes Disperse Red 1, Disperse Red 13 and Disperse Orange 1 and to remove their toxic properties, as an alternative method for the treatment of effluents and water.	Water	274-279	adenosine deaminase RNA specific B1	Homo sapiens	131-136
17457822-6	2007	PPARgamma activators significantly increased PPARgamma-regulated gene (catalase and CD36) expression, whereas reducing proinflammatory gene (tumor necrosis factor-alpha, interleukin-1beta, matrix metalloproteinase-9, and inducible nitric oxide synthase) expression, extracellular H(2)O(2) level, and neuronal damage.	Water	280-285	peroxisome proliferator activated receptor gamma	Mus musculus	0-9
23531819-0	2013	Identification and characterisation of a functional aquaporin water channel (Anomala cuprea DRIP) in a coleopteran insect.	Water	62-67	aquaporin	Xenopus laevis	52-61
17360952-7	2007	Moreover, plasma renin concentration was significantly lower in PAC1-/- compared with their wild-type littermates under control conditions as well as under a low- or high-salt diet and under treatment with the angiotensin-converting enzyme inhibitor ramipril, whereas no differences in plasma renin concentration between the genotypes were detectable after water deprivation.	Water	357-362	renin	Rattus norvegicus	17-22
23531819-1	2013	Water transport across the plasma membrane depends on the presence of the water channel aquaporin (AQP), which mediates the bulk movement of water through osmotic and pressure gradients.	Water	0-5	aquaporin	Xenopus laevis	88-97
23531819-1	2013	Water transport across the plasma membrane depends on the presence of the water channel aquaporin (AQP), which mediates the bulk movement of water through osmotic and pressure gradients.	Water	74-79	aquaporin	Xenopus laevis	88-97
23531819-1	2013	Water transport across the plasma membrane depends on the presence of the water channel aquaporin (AQP), which mediates the bulk movement of water through osmotic and pressure gradients.	Water	141-146	aquaporin	Xenopus laevis	88-97
17283064-0	2007	Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption.	Water	102-107	secretin	Mus musculus	24-32
23531819-5	2013	When expressed in Xenopus laevis oocytes, Anocu AQP1 showed the hallmarks of aquaporin-mediated water transport but no glycerol or urea permeability, and the reversible inhibition of elevated water transport through 1 mmol l(-1) HgCl2.	Water	96-101	aquaporin	Xenopus laevis	77-86
24712284-1	2013	UNLABELLED: The renin-angiotensin system plays a crucial role in the regulation of cardiovascular function and maintenance of water-electrolyte balance.	Water	126-131	renin	Rattus norvegicus	16-21
17283064-6	2007	By using SCTR(-/-) mice as controls and comparing them with wild-type animals, we performed both in vivo and in vitro studies that demonstrated a role for secretin in stimulating (i) AQP2 translocation from intracellular vesicles to the plasma membrane in renal medullary tubules and (ii) expression of this water channel under hyperosmotic conditions.	Water	308-313	secretin	Mus musculus	155-163
17317222-2	2007	We tested the hypothesis that the postprandial changes in plasma GLP-1 concentrations are associated with changes in the human brain activity in response to satiety by performing a post-hoc analysis of a cross-sectional study of neuroanatomical correlates of hunger and satiation using (15)O-water positron-emission tomography (PET).	Water	292-297	glucagon like peptide 1 receptor	Homo sapiens	65-70
23670301-12	2013	Thus, MAO-A and MAO-B are both expressed in the mouse aorta, induced by in vivo lipopolysaccharide and angiotensin II treatment and contribute via the generation of H(2)O(2) to endothelial dysfunction in vascular disease models.	Water	165-170	monoamine oxidase A	Mus musculus	6-11
17339485-5	2007	A water-soluble tanshinone IIA sodium sulfonate derivative (TSNIIA-SS), which has been widely used as a Chinese medicine for patients with cardiovascular disorders, selectively abrogated endotoxin-induced HMGB1 cytoplasmic translocation and release in a glucocorticoid receptor-independent manner.	Water	2-7	high mobility group box 1	Homo sapiens	205-210
17315976-5	2007	PPP5-R polyplex shows enhanced water solubility due to the polymer"s PEG core and also shows low cytotoxicity, representing the potential for in vivo application.	Water	31-36	protein phosphatase 5 catalytic subunit	Homo sapiens	0-4
24417139-2	2013	METHODS: Polysaccharides extracted from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba with water were precipitated by ethanol and named as BSEP-S and BSEP-C, respectively.	Water	104-109	afamin	Homo sapiens	94-98
17068482-8	2007	Previous reports suggest the existence of a water flux sensor in the epidermis, and as TRPV4 is known to be activated by osmotic pressure, our results indicate that it might be this sensor.	Water	44-49	transient receptor potential cation channel subfamily V member 4	Homo sapiens	87-92
17023553-8	2007	Water-immersion restraint stress (WIR)-induced increases in gastric tissue levels of CGRP and 6-keto-PGF(1alpha) were inhibited in ovariectomized rats.	Water	0-5	calcitonin-related polypeptide alpha	Rattus norvegicus	85-89
17171560-10	2007	Development of SPR screening methods enables application of such an approach for quantification of these compounds in water.	Water	118-123	sepiapterin reductase	Homo sapiens	15-18
17504062-4	2007	When the bone regeneration was evaluated by soft radiography and bone mineral density (BMD) examinations, the gelatin hydrogel incorporating BMP-2 exhibited significantly higher osteoinduction activity than did an insoluble bone matrix that incorporated BMP-2 (one of the best osteoinduction systems), although the activity depended on the water content of hydrogels.	Water	340-345	bone morphogenetic protein 2	Macaca fascicularis	141-146
17243837-7	2007	The reaction coordinates of the ribozyme reaction in TS, RC1-CD1 and RC4-CD2, are 2.35 and 2.33 A, respectively, compared to 2.37 and 2.36 A in water.	Water	144-149	CD1c molecule	Homo sapiens	61-64
17126319-3	2007	Free access to both water and a caffeinated solution (30 mg/100 ml) for 14 days increased total fluid intake only in adenosine A1 receptor +/+ mice (by 23+/-3%), and both total fluid intake and plasma renin concentration were no longer different between genotypes.	Water	20-25	adenosine A1 receptor	Mus musculus	117-138
17140551-1	2007	Within a set of food-related Amadori compounds, crystalline N-(1-deoxy-beta-D-fructopyranos-1-yl)-l-histidine monohydrate (Fru-l-HisxH(2)O) has an unusually low solubility in water, which we determined as 0.21 g/100 g at 25 degrees C. The majority of the other fructose-amino acid conjugates have solubilities exceeding 100 g/100 g in water at this temperature.	Water	175-180	zinc finger and BTB domain containing 22	Homo sapiens	123-126
17140551-1	2007	Within a set of food-related Amadori compounds, crystalline N-(1-deoxy-beta-D-fructopyranos-1-yl)-l-histidine monohydrate (Fru-l-HisxH(2)O) has an unusually low solubility in water, which we determined as 0.21 g/100 g at 25 degrees C. The majority of the other fructose-amino acid conjugates have solubilities exceeding 100 g/100 g in water at this temperature.	Water	335-340	zinc finger and BTB domain containing 22	Homo sapiens	123-126
17201391-0	2007	Reaction of O2 with the hydrogen atom in water up to 350 degrees C. The reaction of the H* atom with O2, giving the hydroperoxyl HO2* radical, has been investigated in pressurized water up to 350 degrees C using pulse radiolysis and deep-UV transient absorption spectroscopy.	Water	41-46	heme oxygenase 2	Homo sapiens	129-132
21204498-0	2007	TRPV4 and TRPM3 as Volume-Regulated Cation Channels Changes of the extracellular osmolarity result in swelling or shrinkage of cells by increases or decreases in intracellular water along the ionic concentration gradient, thereby changing cell volume.	Water	176-181	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
17265559-2	2007	The first two extracts, SA1 and SA2, isolated at room temperature by ethyl acetate and water extraction, respectively, neutralized the enterovirus 71-induced cytopathic effect in Vero, rhabdomyosarcoma and MRC-5 cells.	Water	87-92	stromal antigen 2	Homo sapiens	32-35
16959946-1	2007	A role of IL-18 in the induction of gastric lesions by water immersion and restraint stress (WRS) was investigated.	Water	55-60	interleukin 18	Mus musculus	10-15
23045145-2	2007	The sEH catalyzes the addition of a water molecule to an epoxide, resulting in the corresponding diol.	Water	36-41	epoxide hydrolase 2	Homo sapiens	4-7
17187938-0	2007	Inhibition of HMGB1 by deep ocean water attenuates endotoxin-induced sepsis.	Water	34-39	high mobility group box 1	Homo sapiens	14-19
17165790-4	2006	The second key finding of this study is that the mechanism of racemization of an alanine zwitterion in water is altered from an essentially concerted process to a stepwise reaction by formation of an external aldimine adduct with the PLP cofactor.	Water	103-108	pyridoxal phosphatase	Homo sapiens	234-237
17129049-2	2006	The ionic liquid C8mimC1C1N is immiscible with water and forms a nonpolarizable interface when in contact with it.	Water	47-52	homeobox C8	Homo sapiens	17-27
17154473-2	2006	In the present study, we synthesized water-soluble chitin by aminoalkylating onto chitin at the C-6 position, and its transfection efficiency was investigated.	Water	37-42	complement C6	Homo sapiens	96-99
17145855-5	2006	SMO/PAOh1 oxidizes spermine into spermidine, 3-aminopropanal, and H(2)O(2).	Water	66-71	spermine oxidase	Homo sapiens	4-9
16956955-0	2006	Identification of binding sites of non-I-helix water molecules in mammalian cytochromes p450.	Water	47-52	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	88-92
16956955-3	2006	The study of P450-bound waters has been largely restricted to bacterial enzymes that may or may not reflect the location or function of waters in human drug-metabolizing P450s.	Water	24-30	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	13-17
16956955-3	2006	The study of P450-bound waters has been largely restricted to bacterial enzymes that may or may not reflect the location or function of waters in human drug-metabolizing P450s.	Water	136-142	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	170-175
16956955-5	2006	Described herein is the identification of seven well defined water clusters in mammalian P450s identified by calculating the density of globally aligned waters as reported by Tanner and coworkers [Bottoms CA, White TA, and Tanner JJ (2006) Proteins 64:404-421 (DOI: 10.1002/prot.21014)].	Water	61-66	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	89-94
16956955-6	2006	All water binding sites were in or within the immediate vicinity of the active sites of the P450s, but most were not near the conserved I-helix threonine often implicated in P450 catalysis.	Water	4-9	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	92-97
16956955-6	2006	All water binding sites were in or within the immediate vicinity of the active sites of the P450s, but most were not near the conserved I-helix threonine often implicated in P450 catalysis.	Water	4-9	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	92-96
16956955-7	2006	Therefore, it is possible that some of the water binding sites identified here ultimately determine P450 catalytic efficiency either by working as an extension of the I-helix water network, or by acting in novel proton shuttles that modulate the nonproductive shunting of reactive oxygen species.	Water	43-48	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	100-104
16956955-7	2006	Therefore, it is possible that some of the water binding sites identified here ultimately determine P450 catalytic efficiency either by working as an extension of the I-helix water network, or by acting in novel proton shuttles that modulate the nonproductive shunting of reactive oxygen species.	Water	175-180	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	100-104
17304841-5	2006	Combined with the solid-phase extraction (SPE) procedure, the yeast assay showed an obvious inhibition of hPR activity for water works sample and the inhibition rates were more than 58 %.	Water	123-128	haptoglobin-related protein	Homo sapiens	106-109
17119521-1	2006	AIM: It has been suggested, that water exercise is less effective than weight-bearing exercise on land for body fat reduction.	Water	33-38	FAT atypical cadherin 1	Homo sapiens	112-115
17008108-4	2006	We show that neuronal overexpression of neprilysin improved the Morris water maze memory performance in mice with memory deficits resulting from overexpression of the AD-causing mutated human amyloid precursor protein (APP).	Water	71-76	membrane metallo endopeptidase	Mus musculus	40-50
17125395-1	2006	X-ray analyses of matrix metalloproteinases (MMPs) have shown that the catalytic zinc ion (Zn1) can bind to one to three water molecules in addition to three conserved histidine residues.	Water	121-126	matrix metallopeptidase 2	Homo sapiens	45-49
17125395-5	2006	On the other hand, B3LYP/OPLS-AA hybrid QM/molecular mechanical calculations in the solvated catalytic domain of the MMP-2 enzyme complemented with electrostatic Poisson-Boltzmann calculations show that the mature enzyme presents most likely a Zn1 ion coordinated by three histidine residues and two water molecules, while the active site glutamic acid is negatively charged.	Water	300-305	matrix metallopeptidase 2	Homo sapiens	117-122
17010316-1	2006	Recently we demonstrated that PP2 (4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), a potent and selective inhibitor of the Src-family tyrosine kinase, markedly enhanced Ras-independent activation of Raf-1 by the combination of phorbol myristate acetate (PMA) and hydrogen peroxide (H(2)O(2)).	Water	301-306	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	30-33
16555051-7	2006	Neuronal AT1 receptors mediate the stimulatory actions of Ang II on blood pressure, water and salt intake, and the secretion of vasopressin.	Water	84-89	angiotensin II receptor type 1	Homo sapiens	9-12
16555051-7	2006	Neuronal AT1 receptors mediate the stimulatory actions of Ang II on blood pressure, water and salt intake, and the secretion of vasopressin.	Water	84-89	angiogenin	Homo sapiens	58-61
17543218-4	2006	Aquaporin 1 (AQP1) is the only AQP present in these cells, and its deletion in AQP1 null mice significantly affects cell osmotic permeability but not fluid transport, which militates against sizable water movements across the cell.	Water	199-204	aquaporin 1	Mus musculus	0-11
17543218-4	2006	Aquaporin 1 (AQP1) is the only AQP present in these cells, and its deletion in AQP1 null mice significantly affects cell osmotic permeability but not fluid transport, which militates against sizable water movements across the cell.	Water	199-204	aquaporin 1	Mus musculus	13-17
17543218-4	2006	Aquaporin 1 (AQP1) is the only AQP present in these cells, and its deletion in AQP1 null mice significantly affects cell osmotic permeability but not fluid transport, which militates against sizable water movements across the cell.	Water	199-204	aquaporin 1	Mus musculus	79-83
17543220-5	2006	AQP7 belongs to the aquaglyceroporin subfamily to permealize glycerol as well as water.	Water	81-86	aquaporin 7	Homo sapiens	0-4
17047754-0	2006	The relaxation of OH (v=1) and OD (v=1) by H2O and D2O at temperatures from 251 to 390 K. We report rate coefficients for the relaxation of OH(v=1) and OD(v=1) by H2O and D2O as a function of temperature between 251 and 390 K. All four rate coefficients exhibit a negative dependence on temperature.	Water	43-46	immunoglobulin kappa variable 1-5	Homo sapiens	22-25
17047754-0	2006	The relaxation of OH (v=1) and OD (v=1) by H2O and D2O at temperatures from 251 to 390 K. We report rate coefficients for the relaxation of OH(v=1) and OD(v=1) by H2O and D2O as a function of temperature between 251 and 390 K. All four rate coefficients exhibit a negative dependence on temperature.	Water	43-46	immunoglobulin kappa variable 1-5	Homo sapiens	35-38
17047754-0	2006	The relaxation of OH (v=1) and OD (v=1) by H2O and D2O at temperatures from 251 to 390 K. We report rate coefficients for the relaxation of OH(v=1) and OD(v=1) by H2O and D2O as a function of temperature between 251 and 390 K. All four rate coefficients exhibit a negative dependence on temperature.	Water	43-46	immunoglobulin kappa variable 1-5	Homo sapiens	35-38
17047754-0	2006	The relaxation of OH (v=1) and OD (v=1) by H2O and D2O at temperatures from 251 to 390 K. We report rate coefficients for the relaxation of OH(v=1) and OD(v=1) by H2O and D2O as a function of temperature between 251 and 390 K. All four rate coefficients exhibit a negative dependence on temperature.	Water	163-166	immunoglobulin kappa variable 1-5	Homo sapiens	22-25
17047754-0	2006	The relaxation of OH (v=1) and OD (v=1) by H2O and D2O at temperatures from 251 to 390 K. We report rate coefficients for the relaxation of OH(v=1) and OD(v=1) by H2O and D2O as a function of temperature between 251 and 390 K. All four rate coefficients exhibit a negative dependence on temperature.	Water	163-166	immunoglobulin kappa variable 1-5	Homo sapiens	35-38
17047754-0	2006	The relaxation of OH (v=1) and OD (v=1) by H2O and D2O at temperatures from 251 to 390 K. We report rate coefficients for the relaxation of OH(v=1) and OD(v=1) by H2O and D2O as a function of temperature between 251 and 390 K. All four rate coefficients exhibit a negative dependence on temperature.	Water	163-166	immunoglobulin kappa variable 1-5	Homo sapiens	35-38
17047754-0	2006	The relaxation of OH (v=1) and OD (v=1) by H2O and D2O at temperatures from 251 to 390 K. We report rate coefficients for the relaxation of OH(v=1) and OD(v=1) by H2O and D2O as a function of temperature between 251 and 390 K. All four rate coefficients exhibit a negative dependence on temperature.	Water	163-166	immunoglobulin kappa variable 1-5	Homo sapiens	35-38
17034184-1	2006	We have observed long-lived OH-stretch (nu(OH)) excitations (v = 1) in water during ultrafast laser ablation by a mid-infrared pulse tuned to the nu(OH) absorption maximum.	Water	71-76	immunoglobulin kappa variable 1-5	Homo sapiens	61-66
17051797-2	2006	Organic carbon and PAH transfer from coal tar particles to water was investigated with closed-looped laboratory column experiments run at various particle sizes and temperatures.	Water	59-64	phenylalanine hydroxylase	Homo sapiens	19-22
17016551-3	2006	show that, in jejunum of mice injected with anti-CD3 or with TNF, fluid accumulation and changes in epithelial phenotype develop, the latter including an increase in the passive permeability to proteins, smaller solutes, and water and the endocytosis of the brush border Na+/H+ exchanger, thereby inhibiting Na+ absorption (a second cytokine, LIGHT, has the former effect, but not the latter) (see the related article beginning on page 2682).	Water	225-230	CD3 antigen, epsilon polypeptide	Mus musculus	49-52
16998070-2	2006	By contrast, lines engineered to overexpress ATGPX3 were less sensitive to drought stress than the wild type and displayed less transpirational water loss, which resulted in higher leaf surface temperature.	Water	144-149	glutathione peroxidase 3	Arabidopsis thaliana	45-51
17075179-1	2006	To investigate the role of ZmPIP1-1 and ZmPIP1-2 in water uptake of roots and drought resistance of crops, semi-quantitative PCR was used to examine the expression of ZmPIP1-1 and ZmPIP1-2 in root systems of different maize genotypes under water deficit.	Water	52-57	aquaporin PIP1-2	Zea mays	40-48
16942222-4	2006	For the inner sphere water molecule in the [Gd(DOTA)(H2O)]- complex the determined quadrupole coupling parameter chi square root of (1 + eta2/3) of 8.7 MHz is very similar to that of the liquid water (9.0 MHz).	Water	21-26	DNA polymerase iota	Homo sapiens	137-143
16942222-4	2006	For the inner sphere water molecule in the [Gd(DOTA)(H2O)]- complex the determined quadrupole coupling parameter chi square root of (1 + eta2/3) of 8.7 MHz is very similar to that of the liquid water (9.0 MHz).	Water	53-57	DNA polymerase iota	Homo sapiens	137-143
16525162-1	2006	Aquaporin-1 (AQP1) and aquaporin-3 (AQP3) water channels expressed in the kidney play a critical role in the urine concentrating mechanism.	Water	42-47	aquaporin 1	Mus musculus	0-11
16581016-0	2006	Aquaporin-1 in the peritoneal membrane: Implications for water transport across capillaries and peritoneal dialysis.	Water	57-62	aquaporin 1	Rattus norvegicus	0-11
16581016-4	2006	The distribution of the water channel aquaporin-1 (AQP1), as well as its molecular structure ensuring an exquisite selectivity for water perfectly fit with the characteristics of the ultrasmall pore.	Water	24-29	aquaporin 1	Rattus norvegicus	38-49
16581016-4	2006	The distribution of the water channel aquaporin-1 (AQP1), as well as its molecular structure ensuring an exquisite selectivity for water perfectly fit with the characteristics of the ultrasmall pore.	Water	24-29	aquaporin 1	Rattus norvegicus	51-55
16581016-4	2006	The distribution of the water channel aquaporin-1 (AQP1), as well as its molecular structure ensuring an exquisite selectivity for water perfectly fit with the characteristics of the ultrasmall pore.	Water	131-136	aquaporin 1	Rattus norvegicus	38-49
16581016-4	2006	The distribution of the water channel aquaporin-1 (AQP1), as well as its molecular structure ensuring an exquisite selectivity for water perfectly fit with the characteristics of the ultrasmall pore.	Water	131-136	aquaporin 1	Rattus norvegicus	51-55
16581016-6	2006	Studies in knockout mice provided further evidence that osmotically-driven water transport across the peritoneal membrane is mediated by AQP1.	Water	75-80	aquaporin 1	Mus musculus	137-141
16581016-10	2006	They also emphasize the critical role of AQP1 during peritoneal dialysis and suggest that manipulating AQP1 expression may be used to increase water permeability across the peritoneal membrane.	Water	143-148	aquaporin 1	Rattus norvegicus	103-107
16814584-1	2006	Neuronal NOS (nNOS) is a constitutively expressed enzyme that catalyzes the oxidation of L-arginine and water to L-citrulline and the gas nitric oxide (NO).	Water	104-109	nitric oxide synthase 1	Homo sapiens	14-18
17048570-8	2006	CONCLUSION: S. tamariscina and it"s water part and n-butanol part have estrogenic activities, effect on ERbeta is greater than ERalpha.	Water	36-41	estrogen receptor 2 (beta)	Mus musculus	104-110
16616209-4	2006	In this study, using the neurosecretory cell line-PC12 cells to set up the model of neuroprotection of preconditioning with H(2)O(2) against apoptosis, we first investigate what changes in expression of iNOS and COX-2 appear during H(2)O(2) preconditioning, then determine if both iNOS inhibitor and COX-2 inhibitor interfere with the neuroprotection elicited by preconditioning with H(2)O(2).	Water	124-129	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	212-217
16616209-4	2006	In this study, using the neurosecretory cell line-PC12 cells to set up the model of neuroprotection of preconditioning with H(2)O(2) against apoptosis, we first investigate what changes in expression of iNOS and COX-2 appear during H(2)O(2) preconditioning, then determine if both iNOS inhibitor and COX-2 inhibitor interfere with the neuroprotection elicited by preconditioning with H(2)O(2).	Water	124-129	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	300-305
16616209-5	2006	We found that preconditioning with H(2)O(2) at 10 microM significantly protected PC12 cells against apoptosis induced by lethal H(2)O(2) (50 microM) and increased the expression of iNOS and COX-2 and that selective iNOS inhibitor, aminoguanidine (AG) and COX-2 inhibitor, NS-398 obviously blocked the protective effects induced by preconditioning with 10 microM H(2)O(2).	Water	35-40	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	190-195
16616209-5	2006	We found that preconditioning with H(2)O(2) at 10 microM significantly protected PC12 cells against apoptosis induced by lethal H(2)O(2) (50 microM) and increased the expression of iNOS and COX-2 and that selective iNOS inhibitor, aminoguanidine (AG) and COX-2 inhibitor, NS-398 obviously blocked the protective effects induced by preconditioning with 10 microM H(2)O(2).	Water	35-40	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	255-260
16907385-0	2006	Hydration and distribution of ions at the mica-water interface.	Water	47-52	MHC class I polypeptide-related sequence A	Homo sapiens	42-46
16838281-0	2006	Pharmacokinetics and stability properties of catalase modified with water-soluble polysaccharides.	Water	68-73	catalase	Bos taurus	45-53
16885125-6	2006	Pegylated IFN alpha encapsulated multivesicular liposomes were prepared by double emulsification technique followed by evaporation of organic solvents from chloroform ether spherules suspended in water.	Water	196-201	interferon alpha 2	Homo sapiens	10-19
16713603-3	2006	In the present study, the effects of a potent water-soluble antioxidant, salvianolic acid B (SalB), derived from a Chinese herb, Salvia miltiorrhiza, on the expression of MMP-2 by TNF-alpha-treated human aortic smooth muscle cells (HASMCs) were investigated.	Water	46-51	matrix metallopeptidase 2	Homo sapiens	171-176
18666628-5	2008	Determination of microorganisms number and ATP level were both examinated in water inlet.	Water	77-82	ATPase phospholipid transporting 8A2	Homo sapiens	43-46
18220086-8	2008	When compared with sham, the mRNA of macrophage inflammatory protein-2 (MIP-2) in nasal tissue was significantly overexpressed after both 3 h (2.28-fold +/- 0.43-fold; P = 0.034) and 5 h (5.56-fold +/-1.88-fold; P = 0.002) of nCPAP=10 cm H2O.	Water	238-241	C-X-C motif chemokine ligand 2	Rattus norvegicus	37-70
18220086-8	2008	When compared with sham, the mRNA of macrophage inflammatory protein-2 (MIP-2) in nasal tissue was significantly overexpressed after both 3 h (2.28-fold +/- 0.43-fold; P = 0.034) and 5 h (5.56-fold +/-1.88-fold; P = 0.002) of nCPAP=10 cm H2O.	Water	238-241	C-X-C motif chemokine ligand 2	Rattus norvegicus	72-77
18220086-10	2008	CONCLUSIONS: The compression applied by nCPAP (10 cm H2O, 5 h) on the nasal wall of healthy rats is a mechanical stimulus that triggers an early inflammatory process mediated by MIP-2, resulting in neutrophil extravasation.	Water	53-56	C-X-C motif chemokine ligand 2	Rattus norvegicus	178-183
17369110-5	2007	AQP1 and AQP5 provide the principal route for osmotically driven water transport between airspace and capillary compartments; however, alveolar fluid clearance in the neonatal and adult lung is not affected by their deletion, nor is lung fluid accumulation in experimental models of lung injury.	Water	65-70	aquaporin 1	Mus musculus	0-4
17985876-2	2007	This equilibrium constant was used to calculate the reduction potential for the L2(H2O)RhOO2+/L2(H2O)RhOOH2+ couple, E0 = 0.97 V vs NHE.	Water	83-86	solute carrier family 9 member C1	Homo sapiens	132-135
17985876-2	2007	This equilibrium constant was used to calculate the reduction potential for the L2(H2O)RhOO2+/L2(H2O)RhOOH2+ couple, E0 = 0.97 V vs NHE.	Water	97-100	solute carrier family 9 member C1	Homo sapiens	132-135
17980997-2	2007	Since the HIV envelope protein gp120 plays a key role in progression of HIV infection, the aim of the present study was to evaluate the toxicity and degradation of gp120 in hepatocytes isolated from liver of alcohol-preferring rats drinking either 15% ethanol in water or pure water for 70 days.	Water	263-268	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	164-169
17299480-8	2007	In people without diabetes, the GLP-1 response was higher when high and low GI preloads were consumed compared with water (P=0.041), with no significant difference between nutritive preloads.	Water	116-121	glucagon like peptide 1 receptor	Homo sapiens	32-37
19192628-2	2007	By means of CD and NMR spectroscopy, we previously characterized four synthetic peptides containing transmembrane segments (TMSs) I, II, V and VI of the OGC, respectively, in TFE/water mixtures and SDS micelles.	Water	179-184	solute carrier family 25 member 11	Homo sapiens	153-156
18001282-1	2007	Following secretion from the posterior pituitary, the neuropeptide vasopressin (AVP) stimulates the kidney to retain water, and when released centrally it can contribute to anxiety- and depression-like behaviours.	Water	117-122	arginine vasopressin	Mus musculus	80-83
19459290-1	2007	Dissipative particle dynamics simulations were performed on the morphology and structure of multicompartment micelles and vesicles formed from pi-shaped ABC block copolymers in water.	Water	177-182	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	153-156
17725618-9	2007	The presence of the hlyA gene in clinical and water Aeromonas isolates was investigated and DNA fingerprint analysis was performed to demonstrate its possible role in Aeromonas virulence.	Water	46-51	hemolysin transport protein	Escherichia coli	20-24
17656429-2	2007	Effective mucin dispersion into ASL requires salt and water secretion onto the mucosal surface, but how mucin secretion rate is coordinated with ion and, ultimately, water transport rates is poorly understood.	Water	54-59	LOC100508689	Homo sapiens	10-15
17696455-3	2007	CnBP(FC14)2 formed a stable monolayer on water at 298.2 K, where these pi-A isotherms shifted to a larger molecular area with increasing charge separation and had no transition point from a disordered phase to an ordered one.	Water	41-46	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	0-4
17762108-2	2007	The structure of the compound exhibits a two-dimensional layer, which is formed by the interconnection of [Zn(C(7)H(6)NO(2))(H2O)]n chains via mu2-nitrate bridges or by the interconnection of [Zn(NO(3))(H2O)]n chains via mu2-4-aminobenzoate bridges.	Water	125-128	adaptor related protein complex 1 subunit mu 2	Homo sapiens	143-146
17513494-9	2007	Furthermore, myocytes acutely treated with H(2)O(2) exhibited a decrease in cleavage of desmin upon exposure to exogenous calpain-1 compared with myocytes not pretreated with H(2)O(2).	Water	43-48	desmin	Rattus norvegicus	88-94
17513494-9	2007	Furthermore, myocytes acutely treated with H(2)O(2) exhibited a decrease in cleavage of desmin upon exposure to exogenous calpain-1 compared with myocytes not pretreated with H(2)O(2).	Water	43-48	calpain 1	Rattus norvegicus	122-131
17513494-9	2007	Furthermore, myocytes acutely treated with H(2)O(2) exhibited a decrease in cleavage of desmin upon exposure to exogenous calpain-1 compared with myocytes not pretreated with H(2)O(2).	Water	175-180	desmin	Rattus norvegicus	88-94
17513494-9	2007	Furthermore, myocytes acutely treated with H(2)O(2) exhibited a decrease in cleavage of desmin upon exposure to exogenous calpain-1 compared with myocytes not pretreated with H(2)O(2).	Water	175-180	calpain 1	Rattus norvegicus	122-131
17713901-2	2007	In the present paper, eight Molecular Dynamics (MD) simulations are carried out to examine the importance of structure and dynamics of water in the active site of both CDK2 and CDK5 complexes with roscovitine and indirubin analogues.	Water	135-140	cyclin dependent kinase 2	Homo sapiens	168-172
17713901-3	2007	Together with previous results, the current work shows a highly conserved water-involved hydrogen bonding (HB) network in both CDK2- and CDK5-indirubin combinations to complete information from the X-ray crystallography.	Water	74-79	cyclin dependent kinase 2	Homo sapiens	127-131
18062230-3	2007	beta-1,3-Glucans have various functions depending on the molecular weight, degree of branching, conformation, water solubility, and intermolecular association.	Water	110-115	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	0-8
17655283-5	2007	HO2 molecules were formed by using either the termolecular association of H atoms in an excess of O2 or via the reaction of F atoms with an excess of H(2)O(2).	Water	150-155	heme oxygenase 2	Homo sapiens	0-3
17620103-5	2007	In the human ocular ciliary epithelium, Na(+) and water secretion is dependent on a novel mediator of ciliary epithelial Na(+) transport, 11beta-HSD type 1 (11beta-HSD1), that generates intraocular cortisol.	Water	50-55	RNA, U1 small nuclear 1	Homo sapiens	138-168
17525153-1	2007	Indirect evidence suggests that the Muller/glial cell water channel aquaporin-4 (AQP4) modulates K(+) channel function of the closely associated Kir4.1 protein.	Water	54-59	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	145-151
17517884-3	2007	Here, we show that exposure of cultured cells to sustained low levels of H(2)O(2) that mimic its release by inflammatory cells leads to up-regulation of transferrin receptor 1 (TfR1), the major iron uptake protein.	Water	73-78	transferrin receptor	Homo sapiens	153-175
17517884-3	2007	Here, we show that exposure of cultured cells to sustained low levels of H(2)O(2) that mimic its release by inflammatory cells leads to up-regulation of transferrin receptor 1 (TfR1), the major iron uptake protein.	Water	73-78	transferrin receptor	Homo sapiens	177-181
17616688-9	2007	Furthermore, exogenous expression of 101F6 enhanced intracellular uptake of ascorbate, leading to an accumulation of cytotoxic H(2)O(2) and a synergistic killing of tumor cells through caspase-independent apoptotic and autophagic pathways.	Water	127-132	cytochrome b561 family member D2	Homo sapiens	37-42
17510212-2	2007	In the kidney, chloride channels CLC-Ka (gene CLCNKA) and CLC-Kb (gene CLCNKB) and their subunit Barttin (gene BSND) have important effects on the control of Na(+) and water homeostasis.	Water	168-173	chloride voltage-gated channel Ka	Homo sapiens	33-39
17510212-2	2007	In the kidney, chloride channels CLC-Ka (gene CLCNKA) and CLC-Kb (gene CLCNKB) and their subunit Barttin (gene BSND) have important effects on the control of Na(+) and water homeostasis.	Water	168-173	chloride voltage-gated channel Ka	Homo sapiens	46-52
17510212-2	2007	In the kidney, chloride channels CLC-Ka (gene CLCNKA) and CLC-Kb (gene CLCNKB) and their subunit Barttin (gene BSND) have important effects on the control of Na(+) and water homeostasis.	Water	168-173	chloride voltage-gated channel Kb	Homo sapiens	58-64
17510212-2	2007	In the kidney, chloride channels CLC-Ka (gene CLCNKA) and CLC-Kb (gene CLCNKB) and their subunit Barttin (gene BSND) have important effects on the control of Na(+) and water homeostasis.	Water	168-173	chloride voltage-gated channel Kb	Homo sapiens	71-77
17551748-9	2007	At this location paracellin-1 might act as selectivity filter for the paracellular movement of ions and water during stimulated secretion.	Water	104-109	claudin 16	Homo sapiens	17-29
17616875-3	2007	The total PAH levels in water samples from all the sampling stations (except at station WB 11), were sufficiently high (&gt; 10 microg/L) to cause acute toxicity to the exposed organisms.	Water	24-29	phenylalanine hydroxylase	Homo sapiens	10-13
17899901-0	2007	Consumption of bottled water by children in the city of Bauru, State of Sao paulo, Brazil -- a brief communication.	Water	23-28	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	72-75
17899901-1	2007	OBJECTIVES: To determine the consumption of bottled water by children in the city of Bauru, State of Sao Paulo, Brazil.	Water	52-57	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	101-104
17899901-7	2007	CONCLUSIONS: An important percentage of children consume bottled water in the city of Bauru, State of Sao Paulo, Brazil.	Water	65-70	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	102-105
17631809-10	2007	RESULTS: The content of IL-8 in tumor tissue of the untreated group was significantly higher than that of the other groups (P&lt;0.01), and that of the cold water-treated group was higher than that of the cold water and WZXTR-treated group (P&lt;0.01) and the cold water and XTSJR-treated group (P&lt;0.05), respectively.	Water	210-215	chemokine (C-X-C motif) ligand 15	Mus musculus	24-28
17516632-8	2007	The structure of the SSAT-spermine-acetyl-coenzyme A complex suggested that Tyr140 acts as general acid and Glu92, through one or more water molecules, acts as the general base during catalysis.	Water	135-140	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	21-25
17555576-8	2007	However, several conserved and treatment specific responses were identified that are consistent with proliferation (Fos, Cdkn1a, Anapc1), and water imbibition (Slc30a3, Slc30a5) responses elicited by EE.	Water	142-147	solute carrier family 30 (zinc transporter), member 5	Mus musculus	169-176
17346867-5	2007	Based on the current EPA cancer slope factor for arsenic, estimated lifetime risks associated with background diet and water at the mean and 90th percentile are 1 per 10,000 and 2 per 10,000, respectively.	Water	119-124	VPS52 subunit of GARP complex	Homo sapiens	157-179
17350647-8	2007	The magnitude of the Dubinin-Radushkevich energetic parameters (E, from 7.00 to 15.00 kJ mol-1) indicates that the adsorption of the dyes onto Sil-NH2, in the absence and in the presence of DBS, is controlled by water adsorbed/dye in solution ion-exchange interactions.	Water	212-217	STIL centriolar assembly protein	Homo sapiens	143-146
17475887-7	2007	When hIRBP-immunized WT mice were administered M5 Ab reacting to SLAYGLR sequence, a cryptic binding site to integrins within OPN, EAU development was significantly ameliorated.	Water	131-134	retinol binding protein 3	Homo sapiens	5-10
17475887-7	2007	When hIRBP-immunized WT mice were administered M5 Ab reacting to SLAYGLR sequence, a cryptic binding site to integrins within OPN, EAU development was significantly ameliorated.	Water	131-134	secreted phosphoprotein 1	Mus musculus	126-129
16870248-11	2007	AQP1 appears to regulate fetal membrane water flow, and AQP3 is a likely candidate for the regulation of placental water flow.	Water	40-45	aquaporin 1	Mus musculus	0-4
17329245-7	2007	The elongation of Pen-2 N terminus caused a reduction in the water accessibility of the luminal side of the catalytic pore of PS1 in a similar manner to that caused by an Abeta42-raising gamma-secretase modulator, fenofibrate, as determined by substituted cysteine accessibility method.	Water	61-66	presenilin 1	Homo sapiens	126-129
17185407-10	2007	These data suggest that activation of AT(1) and glutamate receptors in PVN, as well as of AT1R in RVLM, contributes to BP maintenance during water deprivation.	Water	141-146	angiotensin II receptor, type 1a	Rattus norvegicus	90-94
17360020-4	2007	A net increase in THMs, HAAs and TOX was observed for a water of low humic content.	Water	56-61	thymocyte selection associated high mobility group box	Homo sapiens	33-36
17628981-11	2007	CONCLUSIONS: (1) AF, AQP1 and AQP2 have its individual specific localization in the rat inner ear, which was close to the parts of endolymph, so regulating water of the endolymph may be possible.	Water	156-161	aquaporin 1	Rattus norvegicus	21-25
17326663-10	2007	Analysis of lipid-protein interactions of the Kir models emphasizes the key role of the M0 (or "slide") helix which lies approximately parallel to the bilayer-water interface and forms a link between the transmembrane and intracellular domains of the channel.	Water	159-164	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	46-49
17360500-1	2007	X-ray structures of bovine heart cytochrome c oxidase have suggested that the enzyme, which reduces O(2) in a process coupled with a proton pumping process, contains a proton pumping pathway (H-pathway) composed of a hydrogen bond network and a water channel located in tandem across the enzyme.	Water	245-250	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	33-53
17314294-8	2007	hAPP tg mice that were treated with lithium or that were crossed with DN-GSK3beta tg mice displayed improved performance in the water maze, preservation of the dendritic structure in the frontal cortex and hippocampus, and decreased tau phosphorylation.	Water	128-133	glycogen synthase kinase 3 alpha	Mus musculus	73-81
17365288-5	2007	Deuterium water also hastened the decomposition of PAH.	Water	10-15	phenylalanine hydroxylase	Homo sapiens	51-54
17098798-4	2007	Here we study VASP-mediated actin-related proteins 2/3 (Arp2/3) complex-dependent actin dynamics using a substrate that mimics the fluid properties of the cell membrane: an oil-water interface.	Water	177-182	enabled	Drosophila melanogaster	14-18
16885197-0	2007	Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats.	Water	103-108	APC regulator of WNT signaling pathway	Rattus norvegicus	0-3
17203165-12	2007	Because BFD has been closely related to arsenic ingestion, our results suggested that continual intake of arsenic in drinking water might provoke AKR1C2 expression that could in turn induce drug resistance in UBC, and AKR1C2 could be a tumor marker for UBC.	Water	126-131	aldo-keto reductase family 1 member C2	Homo sapiens	146-152
17198718-5	2007	When expressed in Xenopus laevis oocytes Oatp1d1 increased uptake of demethylphalloin (Km approximately 2.2 microM) and microcystin-LR (Km approximately 27 microM) 2- to 3-fold over water-injected oocytes, whereas the alternative skate liver organic anion transporter, the dimeric Ostalpha/beta, exhibited no phalloidin and only minor microcystin-LR transport.	Water	182-187	solute carrier organic anion transporter family member 1A2	Homo sapiens	41-48
17198718-8	2007	The findings support the notion that Oatp1d1 is a precursor of the liver-specific mammalian Oatps/OATPs and that its transport properties are closely associated with certain forms of toxic liver injury such as for example protein phosphatase inhibition by the water-borne toxin microcystin.	Water	260-265	solute carrier organic anion transporter family member 1A2	Homo sapiens	37-44
17222344-5	2007	In silico panning was successfully applied to the selection of peptide inhibitor for water-soluble quinoprotein glucose dehydrogenase (PQQGDH).	Water	85-90	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	112-133
17009386-1	2007	A series of six new ligands (L(1)-L(6)) suitable for the formation of luminescent lanthanide complexes in water is described.	Water	106-111	transmembrane 4 L six family member 1	Homo sapiens	34-38
17150203-4	2007	RESULTS: Stimulation with low concentrations of H(2)O(2) (1-50 microM) enhances cytotrophoblastic hCG secretion, whereas concentrations of H(2)O(2) &gt;50 microM reduce hCG secretion in a dose-dependent manner.	Water	48-53	hypertrichosis 2 (generalised, congenital)	Homo sapiens	98-101
17342347-1	2007	The effect of a decoction of pulverized aloe leaves (Aloe marlothii) mixed with tap water and administered orally through a gastric tube was determined against ticks on cattle.	Water	84-89	tracheal antimicrobial peptide	Bos taurus	80-83
17106869-8	2007	Taken together, these data indicate that the water extract of Omija protects H9c2 cardiomyoblast cells from oxidative stress of H(2)O(2) through inhibition of mitochondrial dysfunction and activation of intrinsic caspase cascades, including caspase-3 and caspase-9.	Water	45-50	caspase 3	Rattus norvegicus	241-250
17147394-0	2006	Solution chemistry of a water-soluble eta2-H2 ruthenium complex: evidence for coordinated H2 acting as a hydrogen bond donor.	Water	24-29	DNA polymerase iota	Homo sapiens	38-42
17147394-3	2006	We present the synthesis of several new water-soluble ruthenium coordination complexes including an eta2-H2 complex that is surprisingly inert to substitution by water.	Water	40-45	DNA polymerase iota	Homo sapiens	100-104
17147394-3	2006	We present the synthesis of several new water-soluble ruthenium coordination complexes including an eta2-H2 complex that is surprisingly inert to substitution by water.	Water	162-167	DNA polymerase iota	Homo sapiens	100-104
17154134-4	2006	The retention characteristics of neutral and sialylated N-glycans derivatized with 2-aminopyridine (PA N-glycans) demonstrate that the retentions of the N-glycans are based primarily on hydrophilic interaction with the water-rich liquid layer generated on the surface of the ZIC-HILIC column.	Water	219-224	Zic family member 1	Homo sapiens	275-278
17079706-4	2006	METHOD: Regional CBF was measured with oxygen-15-labeled water and positron emission tomography during a public speaking task before and after placebo treatment in 12 subjects with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-defined SAD.	Water	57-62	CCAAT/enhancer binding protein zeta	Rattus norvegicus	17-20
16785034-6	2006	Overexpression of human manganese superoxide dismutase in PAEC reduced O(2)*(-) levels and attenuated cytotoxicity resulting from treatment with H(2)O(2).	Water	145-150	superoxide dismutase 2	Homo sapiens	24-54
16722672-8	2006	A simplified reaction scheme was delineated: NO + HO2 --&gt; NO2 + OH followed by OH + CH4 --&gt; CH3 + H2O and OH + C2H6 --&gt; C2H5 + H2O.	Water	136-139	heme oxygenase 2	Homo sapiens	50-53
23742636-0	2013	Aromatic naphthenic acids in oil sands process-affected water, resolved by GCxGC-MS, only weakly induce the gene for vitellogenin production in zebrafish (Danio rerio) larvae.	Water	56-61	vitellogenin	Danio rerio	117-129
17054360-4	2006	Quenching is approximately twice as effective in acetonitrile/water (95:5) (K(SV) = 3.1 x 10(5) M(-1) for CP1a and 1.1 x 10(5) M(-1) for CP1b).	Water	62-67	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	137-141
23632463-3	2013	In this study the dependence of charge separation efficiency (eta(sep)) on potential during photoelectrochemical water splitting at pH 2 has been quantified in a model electrode system (nanocrystalline, mesoporous TiO2) using two independent methods.	Water	113-118	endothelin receptor type A	Homo sapiens	62-65
17042492-2	2006	Fet3p is a ferroxidase that, like ceruloplasmin and hephaestin, couples the oxidation of 4 equiv of Fe(II) to the reduction of O2 to 2 H2O.	Water	135-138	ferroxidase FET3	Saccharomyces cerevisiae S288C	0-5
17155323-4	2006	Motivated by these results, we show that the transition from hadrons to quarks and gluons has behavior similar to helium, nitrogen, and water at and near their phase transitions in the ratio eta/s.	Water	136-141	endothelin receptor type A	Homo sapiens	191-194
23632463-5	2013	The techniques provide good agreement with each other and show that a low maximum value of eta(sep) (~0.18) is the primary cause of the low IPCE for water oxidation on these nc-TiO2 electrodes.	Water	149-154	endothelin receptor type A	Homo sapiens	91-94
23735000-1	2013	Aquaporin-1 (AQP1) is a water channel that is highly expressed on the apical side of the choroid plexus epithelium (CP) and thought to be one of the major pathways for the high water permeability of this structure.	Water	24-29	aquaporin 1	Rattus norvegicus	0-11
17003437-4	2006	METHODS: EAU was induced in OPN-null and wild-type (WT) mice by immunization with interphotoreceptor retinoid-binding protein (IRBP).	Water	9-12	secreted phosphoprotein 1	Mus musculus	28-31
17003437-7	2006	To determine whether OPN could induce an EAU-like condition, purified OPN and OPN fragments were injected intraocularly into WT mice and vitreous infiltrates were characterized and quantified.	Water	41-44	secreted phosphoprotein 1	Mus musculus	21-24
23735000-1	2013	Aquaporin-1 (AQP1) is a water channel that is highly expressed on the apical side of the choroid plexus epithelium (CP) and thought to be one of the major pathways for the high water permeability of this structure.	Water	24-29	aquaporin 1	Rattus norvegicus	13-17
23735000-1	2013	Aquaporin-1 (AQP1) is a water channel that is highly expressed on the apical side of the choroid plexus epithelium (CP) and thought to be one of the major pathways for the high water permeability of this structure.	Water	177-182	aquaporin 1	Rattus norvegicus	0-11
17044001-2	2006	At present, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules (AQP0, AQP1, AQP2, AQP4, AQP5, AQP6, and AQP8), or also glycerol and other small solutes (AQP3, AQP7, AQP9, AQP10, AQP12).	Water	121-126	aquaporin 7	Homo sapiens	233-237
23735000-1	2013	Aquaporin-1 (AQP1) is a water channel that is highly expressed on the apical side of the choroid plexus epithelium (CP) and thought to be one of the major pathways for the high water permeability of this structure.	Water	177-182	aquaporin 1	Rattus norvegicus	13-17
17044001-2	2006	At present, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules (AQP0, AQP1, AQP2, AQP4, AQP5, AQP6, and AQP8), or also glycerol and other small solutes (AQP3, AQP7, AQP9, AQP10, AQP12).	Water	121-126	aquaporin 10	Homo sapiens	245-250
23582352-7	2013	On the other hand, the four HANs, CPK and 111TCPone generally had spatial profiles involving an increase of the concentrations along the network according to increasing water residence times, whereas 11DCPone overall had a profile where concentrations increased at the beginning of the network, followed by a drop in the concentrations towards the ends of the network.	Water	169-174	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	34-37
16914136-3	2006	In the presence of 10 muM A23187, 100 nM phorbol myristate acetate (PMA) and 1 mM H(2)O(2) synergistically stimulated arachidonic acid release from L929 cells and C12-cPLA(2)alpha cells, and to a much lesser extent from C12 cells.	Water	82-87	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	167-179
24059948-17	2013	There were statistically positive correlations between AQP-1 mRNA expression and myocardial water ratio (r = 0.849, P &lt; 0.01), AQP-1 mRNA expression and the serum content of cTnI (r = 0.973, P &lt; 0.01) in scald group.	Water	92-97	aquaporin 1	Rattus norvegicus	55-60
16971984-1	2006	We report a Molecular Dynamics (MD) study of the interface between water and the hygroscopic room temperature Ionic Liquid "IL" [BMI][PF6] (1-butyl-3-methyl-imidazolium hexafluorophosphate), comparing the TIP3P, SPC/E and TIP5P models for water and two IL models where the ions are +/-1 or +/-0.9 charged.	Water	67-72	sperm associated antigen 17	Homo sapiens	134-137
16971984-1	2006	We report a Molecular Dynamics (MD) study of the interface between water and the hygroscopic room temperature Ionic Liquid "IL" [BMI][PF6] (1-butyl-3-methyl-imidazolium hexafluorophosphate), comparing the TIP3P, SPC/E and TIP5P models for water and two IL models where the ions are +/-1 or +/-0.9 charged.	Water	239-244	sperm associated antigen 17	Homo sapiens	134-137
23679914-2	2013	We found that the activation barrier of H2O dissociation at the kinked site of the Ga-terminated GaN surface is about 0.8 eV, which is significantly lower than that at the stepped site of about 1.2 eV.	Water	40-43	gigaxonin	Homo sapiens	97-100
16936111-0	2006	Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice.	Water	59-64	aquaporin 1	Mus musculus	81-92
16936111-1	2006	PURPOSE: To investigate the involvement of aquaporin (AQP)-1 in lens epithelial cell water permeability and maintenance of lens transparency in experimental models of cataract formation.	Water	85-90	aquaporin 1	Mus musculus	54-60
16936111-9	2006	AQP1 deficiency reduced plasma membrane water permeability in lens epithelium by 2.8 +/- 0.3-fold (P &lt; 0.0001).	Water	40-45	aquaporin 1	Mus musculus	0-4
23546302-7	2013	For the FAU membrane the hydrophilicity can assist the water molecules entering the nanopore with reduced pressure drop, while for the hydrophobic MFI zeolite additional pressure drop arises from the capillary resistance.	Water	55-60	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	8-11
16804678-5	2006	The detailed hydrogen-bonding geometries depicted in the active site of nNOS structures indicate that it is the ordered active-site water molecule rather than the substrate itself that would most likely serve as a direct proton donor to the diatomic ligands (CO, NO, as well as O(2)) bound to the heme.	Water	132-137	nitric oxide synthase 1	Homo sapiens	72-76
23425894-6	2013	RESULTS: During flushing, PAH levels frequently exceeded drinking water quality standards; after flushing, these levels dropped rapidly.	Water	66-71	phenylalanine hydroxylase	Homo sapiens	26-29
16845482-6	2006	The large water soluble domain of FRO2, which contains NADPH, FAD and oxidoreductase sequence motifs, was located on the inside of the membrane.	Water	10-15	ferric reduction oxidase 2	Arabidopsis thaliana	34-38
23425894-8	2013	CONCLUSIONS: The estimated margin of exposure for PAH exposure through drinking water was &gt; 10,000 for all 120 measurement locations, which suggests that PAH exposure through drinking water is of low concern for consumer health.	Water	80-85	phenylalanine hydroxylase	Homo sapiens	50-53
23425894-8	2013	CONCLUSIONS: The estimated margin of exposure for PAH exposure through drinking water was &gt; 10,000 for all 120 measurement locations, which suggests that PAH exposure through drinking water is of low concern for consumer health.	Water	80-85	phenylalanine hydroxylase	Homo sapiens	157-160
23425894-8	2013	CONCLUSIONS: The estimated margin of exposure for PAH exposure through drinking water was &gt; 10,000 for all 120 measurement locations, which suggests that PAH exposure through drinking water is of low concern for consumer health.	Water	187-192	phenylalanine hydroxylase	Homo sapiens	50-53
16844240-9	2006	The correlation between Cd uptake and DMT1 expression suggests that one route of uptake of Cd, either from the diet or from the water, could be via DMT1.	Water	128-133	solute carrier family 11 member 2	Danio rerio	38-42
23425894-8	2013	CONCLUSIONS: The estimated margin of exposure for PAH exposure through drinking water was &gt; 10,000 for all 120 measurement locations, which suggests that PAH exposure through drinking water is of low concern for consumer health.	Water	187-192	phenylalanine hydroxylase	Homo sapiens	157-160
16844240-9	2006	The correlation between Cd uptake and DMT1 expression suggests that one route of uptake of Cd, either from the diet or from the water, could be via DMT1.	Water	128-133	solute carrier family 11 member 2	Danio rerio	148-152
23425894-9	2013	However, factors that differ among water systems, such as the use of chlorination for disinfection, may influence PAH levels in other locations.	Water	35-40	phenylalanine hydroxylase	Homo sapiens	114-117
23395804-1	2013	Prolactin (PRL) is a well-known regulator of ion and water transport within osmoregulatory tissues across vertebrate species, yet how PRL acts on some of its target tissues remains poorly understood.	Water	53-58	prolactin	Danio rerio	0-9
16913678-0	2006	Infrared spectra and intensities of the H2O and N2 complexes in the range of the nu1- and nu3-bands of water.	Water	103-108	MT-RNR2 like 2 (pseudogene)	Homo sapiens	40-50
23395804-1	2013	Prolactin (PRL) is a well-known regulator of ion and water transport within osmoregulatory tissues across vertebrate species, yet how PRL acts on some of its target tissues remains poorly understood.	Water	53-58	prolactin	Danio rerio	11-14
23462864-0	2013	Reversible binding and quantification of heparin and chondroitin sulfate in water using redox-stable biferrocenylene SAMs.	Water	76-81	methionine adenosyltransferase 1A	Homo sapiens	117-121
16893168-2	2006	Here, the Ca(2+)-dependent membrane interactions of a water soluble fragment of synaptotagmin I (C2AB) that contains its two C2 domains (C2A and C2B) were determined using site-directed spin labeling.	Water	54-59	synaptotagmin 1	Homo sapiens	80-95
23614446-7	2013	In this work, we present a detailed computational analysis of the folding pathways that arise between the various conformational states of human amylin in water.	Water	155-160	islet amyloid polypeptide	Homo sapiens	145-151
16774763-0	2006	Dynamics of water droplets detached from porous surfaces of relevance to PEM fuel cells.	Water	12-17	mucin 1, cell surface associated	Homo sapiens	73-76
16774763-2	2006	CCD images taken on a purpose-built transparent fuel cell have revealed that the water produced within the PEM is forming droplets on the surface of the gas-diffusion layer.	Water	81-86	mucin 1, cell surface associated	Homo sapiens	107-110
23614446-8	2013	A free energy surface for amylin in explicit water is first constructed by resorting to advanced sampling techniques.	Water	45-50	islet amyloid polypeptide	Homo sapiens	26-32
16838159-0	2006	Measurement of hydrolysis kinetics of galactose-substituted fluorescein by beta-galactosidase at the toluene-water interface by spinning microtube fluorometry.	Water	109-114	galactosidase beta 1	Homo sapiens	75-93
24719493-4	2013	Functionality of the spectroscopic module of the prototype device is illustrated through the detection of 1Eta resonance in deionized water.	Water	134-139	endothelin receptor type A	Homo sapiens	107-110
16860289-6	2006	Although AQP7 solo knockout mice did not show a urinary concentrating defect, AQP1/AQP7 double knockout mice showed reduced urinary concentrating ability compared to AQP1 solo knockout mice, indicating that the contribution of AQP7 to water reabsorption in the proximal straight tubules is physiologically substantial.	Water	235-240	aquaporin 1	Mus musculus	78-82
16680807-6	2006	Results from DSC experiments demonstrate that only non-freezable bound water and free water can be distinguished in the fibrous membrane.	Water	71-76	desmocollin 3	Homo sapiens	13-16
16680807-6	2006	Results from DSC experiments demonstrate that only non-freezable bound water and free water can be distinguished in the fibrous membrane.	Water	86-91	desmocollin 3	Homo sapiens	13-16
23328494-1	2013	BACKGROUND: 4Z,15Z-bilirubin-IXalpha (BR), an endogenous toxic compound that is sparingly soluble in water, binds human serum albumin (HSA) with high affinity in a flexible manner.	Water	101-106	albumin	Mus musculus	120-133
16683800-4	2006	According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, solvation facilitates the transition of the chelating nitrate ligand to a eta1-bonding mode: the free energy of UO2(eta2-NO3)(eta1-NO3)(OH2)2 relative to the bis-chelating minimum drops from 3.9 kcal/mol in vacuo to 1.4 kcal/mol in water.	Water	335-340	DNA polymerase iota	Homo sapiens	219-223
16902942-0	2006	Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones.	Water	36-41	adenosine A1 receptor	Homo sapiens	56-77
23181759-2	2013	In the present study, in vivo experiments using a non-invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation.	Water	126-131	insulin receptor	Homo sapiens	394-410
32680228-3	2006	TGA and elemental analysis indicate that the water content of the incubated PVPON-PAA film is only ~4%.	Water	45-50	T-box transcription factor 1	Homo sapiens	0-3
16500969-8	2006	Because the diffusion constant of the bead is 60-fold lower than myosin-VI heads alone in water, we propose a model in which the bead acts as a diffusional anchor for the myosin-VI, enhancing its rebinding following detachment and supporting processive movement of the bead-monomer complexes.	Water	90-95	myosin VI	Homo sapiens	65-74
16500969-8	2006	Because the diffusion constant of the bead is 60-fold lower than myosin-VI heads alone in water, we propose a model in which the bead acts as a diffusional anchor for the myosin-VI, enhancing its rebinding following detachment and supporting processive movement of the bead-monomer complexes.	Water	90-95	myosin VI	Homo sapiens	171-180
16543266-8	2006	Thus, we propose that weight loss decreases Ang II-elicited water intake in the female rat by down-regulating the expression of the AT1 receptor.	Water	60-65	angiotensin II receptor, type 1a	Rattus norvegicus	132-135
16494987-8	2006	The expression in ASI neurons of human T2R16, the ligand of which, phenyl-beta-d-glucopyranoside, belong to a chemically different group of bitter tastants, also counteracted the water-soluble avoidance to this compound observed in wild-type worms.	Water	179-184	taste 2 receptor member 16	Homo sapiens	39-44
23159038-7	2013	Dissection of protonation-deprotonation reactions of both the water molecule bound to the CA XII active site and the sulfonamide group of the inhibitor yielded the intrinsic thermodynamic parameters of binding, such as binding enthalpy, entropy and Gibbs free energy.	Water	62-67	carbonic anhydrase 12	Homo sapiens	90-96
16961727-1	2006	Soluble epoxide hydrolase (sEH) is an enzyme responsible for the conversion of lipid epoxides to diols by the addition of water.	Water	122-127	epoxide hydrolase 2	Homo sapiens	0-25
16961727-1	2006	Soluble epoxide hydrolase (sEH) is an enzyme responsible for the conversion of lipid epoxides to diols by the addition of water.	Water	122-127	epoxide hydrolase 2	Homo sapiens	27-30
16824059-4	2006	The aim of the present study was to investigate the effect of water-immersion stress on serum, stomach and adipose tissue leptin levels to understand the relationship between stress and eating behavior.	Water	62-67	leptin	Rattus norvegicus	122-128
23276665-9	2013	Since donepezil and memantine have been widely used for treating patients of Alzheimer"s disease, these results also suggest that cognitive deficits in PS1/APP mice assessed in the Y-maze and Morris water maze tasks are a useful animal model for evaluating novel Alzheimer"s disease therapeutics.	Water	199-204	presenilin 1	Homo sapiens	152-159
16824059-6	2006	The leptin level in the serum, gastric mucosa and adipose tissue was measured using ELISA system before and after the initiation of water-immersion stress.	Water	132-137	leptin	Rattus norvegicus	4-10
16824059-7	2006	RESULTS: The serum leptin level was significantly increased by water-immersion stress.	Water	63-68	leptin	Rattus norvegicus	19-25
16721855-2	2006	Current views suggest that the non-structural protein 4 (NSP4) of rotavirus and the enteric nervous system (ENS) participate in water secretion and diarrhoea.	Water	128-133	serine protease 57	Homo sapiens	31-55
16721855-2	2006	Current views suggest that the non-structural protein 4 (NSP4) of rotavirus and the enteric nervous system (ENS) participate in water secretion and diarrhoea.	Water	128-133	serine protease 57	Homo sapiens	57-61
16640419-8	2006	For the interaction of H(2)O molecules adsorbed on amorphous AA films, the comparison of MIES with the DFT results of ref 1 shows that the initial phase of exposure does not lead to the formation of a top-adsorbed closed water film at 80 K. Rather, the H(2)O molecules become attached to or incorporated into the preexisting AA network by H bonding; no water network is formed in the initial stage of the water adsorption.	Water	23-28	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	118-123
23307067-2	2013	It has been applied to the data presented by Blok and Loman characterizing the oxygen effect in SSB and DSB formation (in water solution and at low-LET radiation) also in the region of very small oxygen concentrations, which cannot be studied with the help of experiments done with living cells.	Water	122-127	small RNA binding exonuclease protection factor La	Homo sapiens	96-99
16696568-3	2006	Animals, including humans, may encounter PST mixtures via consumption of tainted seafood, contaminated water, or the microalgae that produce the toxins.	Water	103-108	sulfotransferase family 1A member 1	Homo sapiens	41-44
17007350-9	2006	The bioactivity of GLP-1 was conserved with glutin as inner water phase, but in the course of in vitro release, the specific activity of CLP-1 in the microspheres decreased a little.	Water	60-65	glucagon	Mus musculus	19-24
22207603-7	2013	Swelling behavior of hydrogel in PBS (pH 6.5 and 7.4, 0.2 M) and in distilled water was found to increase with increasing AAc/HEMA ratio.	Water	78-83	glycine-N-acyltransferase	Mus musculus	122-125
16574131-2	2006	Hexafluorophosphate (PF(6)(-)) adsorption isotherms were measured from acetonitrile/water and methanol/water mixtures.	Water	84-89	sperm associated antigen 17	Homo sapiens	21-26
16574131-2	2006	Hexafluorophosphate (PF(6)(-)) adsorption isotherms were measured from acetonitrile/water and methanol/water mixtures.	Water	103-108	sperm associated antigen 17	Homo sapiens	21-26
16779580-17	2006	A viscous hydrocarbon paste uncovered in API 1 was insoluble in water but dissolved in dichloromethane.	Water	64-69	baculoviral IAP repeat containing 2	Homo sapiens	41-46
16711747-0	2006	A quantum chemical study of the catalysis for cytidine deaminase: contribution of the extra water molecule.	Water	92-97	cytidine deaminase	Homo sapiens	46-64
23288782-4	2013	In an effort to solve this problem, we have now synthesized and tested a new prodrug of 2-ME2 that is water-soluble due to a bioreversible hydrophilic group added at the 3-position and that more effectively resists metabolic inactivation due to an ester moiety added to mask the 17-position alcohol.	Water	102-107	malic enzyme 2, NAD(+)-dependent, mitochondrial	Mus musculus	90-93
16711747-2	2006	Cytidine with water is efficiently converted to uridine with ammonia in the cleft of cytidine deaminase.	Water	14-19	cytidine deaminase	Homo sapiens	85-103
16711747-5	2006	Our computations showed that the extra water molecule from the solvent has a possibility to support the catalysis of cytidine deaminase.	Water	39-44	cytidine deaminase	Homo sapiens	117-135
16776504-3	2006	In acidic solution (HCl) and at intermediate pH values (acetate buffers), water attack (k1(H2O) is rate limiting for 8-Me, 8-Et, and 8-s-Bu; the same is presumably the case for 8-t-Bu, but rates were too slow for accurate measurements at low pH.	Water	74-79	keratin 1	Homo sapiens	88-94
16785027-2	2006	We found that mitochondrial mass and the intracellular level of H(2)O(2) were increased by exogenous H(2)O(2), which was accompanied with up-regulation of functional PKCdelta.	Water	64-69	protein kinase C delta	Homo sapiens	166-174
23330548-7	2013	The developed turn-on NIR fluorescence probe offered excellent water solubility, stability, and biocompatibility, and exhibited high specificity to TfR with negligible cytotoxicity.	Water	63-68	transferrin receptor	Homo sapiens	148-151
16914952-1	2006	In the present study, involvement of D1 and D2 dopamine receptors in the antinociception and tolerance induced by water swim stress in the formalin test has been investigated.	Water	114-119	dopamine receptor D2	Homo sapiens	37-65
16508653-0	2006	Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis.	Water	39-44	aquaporin 1	Mus musculus	0-11
16508653-1	2006	The water channel aquaporin-1 (AQP1) is considered as the molecular counterpart of the ultrasmall pore predicted by the three-pore model of fluid transport across the peritoneal membrane.	Water	4-9	aquaporin 1	Mus musculus	18-29
16508653-1	2006	The water channel aquaporin-1 (AQP1) is considered as the molecular counterpart of the ultrasmall pore predicted by the three-pore model of fluid transport across the peritoneal membrane.	Water	4-9	aquaporin 1	Mus musculus	31-35
16508653-2	2006	However, the definitive proof of the implication of AQP1 in solute-free water transport, sodium sieving, and ultrafiltration (UF) during peritoneal dialysis (PD) is lacking, and the effects of its deletion on the structure of the membrane are unknown.	Water	72-77	aquaporin 1	Mus musculus	52-56
16713493-2	2006	Mice lacking AQP1 are unable to concentrate their urine because of low water permeability in the proximal tubule, thin descending limb of Henle, and outer medullary descending vasa recta, resulting in defective near-isosmolar fluid absorption in the proximal tubule and defective countercurrent multiplication.	Water	71-76	aquaporin 1	Mus musculus	13-17
16631138-6	2006	Light onset injection of ghrelin suppressed non-rapid-eye-movement sleep (NREMS) and rapid-eye-movement sleep (REMS) for 2 h. In the first hour, ghrelin induced increases in behavioral activity including feeding, exploring, and grooming and stimulated food and water intake.	Water	261-266	ghrelin and obestatin prepropeptide	Rattus norvegicus	25-32
23428980-4	2013	In contrast to the segmented duct system in the rat, all the duct cells in the monkey pancreas consistently displayed rich mitochondria in the cytoplasm, elaborate interdigitations of cell processes, and an intense immunoreactivity for AQP1 on the apical and basolateral cell membrane to favor active ion transport and osmotic water movement across the epithelium.	Water	327-332	aquaporin 1	Rattus norvegicus	236-240
16631138-6	2006	Light onset injection of ghrelin suppressed non-rapid-eye-movement sleep (NREMS) and rapid-eye-movement sleep (REMS) for 2 h. In the first hour, ghrelin induced increases in behavioral activity including feeding, exploring, and grooming and stimulated food and water intake.	Water	261-266	ghrelin and obestatin prepropeptide	Rattus norvegicus	145-152
23232969-2	2013	Clinical trials to date indicate that its water-soluble prodrug, combretastatin A-4 phosphate (CA-4P), is well tolerated at therapeutically useful doses.	Water	42-47	carbonic anhydrase 4	Homo sapiens	65-83
16420189-1	2006	Synthesis of Bz-Arg-Gly-NH(2) (N-benzoylargininylglycinamide) [a precursor dipeptide of RGDS (Arg-Gly-Asp-Ser)] catalysed by protease in water/organic co-solvent systems was studied.	Water	137-142	ral guanine nucleotide dissociation stimulator	Homo sapiens	88-92
16470870-5	2006	Maximum GOS3 synthesis was reached at a water activity interval of 0.44-0.57, with lactose concentrations of 0.06%-0.1%, while GOS4 and GOS5 maxima were reached at water activity intervals of 0.47-0.57 and 0.49-0.60, respectively.	Water	40-45	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	8-12
23184230-0	2013	Role of the putative osmosensor Arabidopsis histidine kinase1 in dehydration avoidance and low-water-potential response.	Water	95-100	protein kinase 2A	Arabidopsis thaliana	54-61
16540146-1	2006	The enzymatic mechanism of acetylcholine hydrolysis was evaluated by semiempirical molecular orbital calculations with a model constructed with the coordinates of sixteen amino acids and four water molecules from the crystallographic structure of Drosophila melanogaster acetylcholinesterase (AChE, entry 1QO9 in the Protein Data Bank).	Water	192-197	Acetylcholine esterase	Drosophila melanogaster	271-291
16430892-7	2006	These results suggest that fugu PRL regulates water and electrolyte balances through PRLR expressed in the osmoregulatory organs, as is the case with freshwater-adapted euryhaline species.	Water	46-51	prolactin receptor	Takifugu rubripes	85-89
23172365-8	2013	Finally, the water soluble azide-reactive phosphine probe, rho-TEO-phosphine (21) (rho: rhodamine), has been designed and applied to attach a chromophore to azido-(K1)RNase A via Staudinger ligation at physiological pH indicating that the introduced azido group is accessible and could be addressed by other established azide-reactive bioorthogonal reaction schemes.	Water	13-18	ribonuclease A family member 1, pancreatic	Homo sapiens	167-174
16584179-6	2006	7, 205-216] of DAP-inhibited urease (PDB code ), and the trimeric structure (2479 residues) resulted in 180K atoms after solvation by water.	Water	134-139	death associated protein	Homo sapiens	15-18
16526652-0	2006	Exploration of the potential energy surfaces, prediction of atmospheric concentrations, and prediction of vibrational spectra for the HO2...(H2O)n (n = 1-2) hydrogen bonded complexes.	Water	141-144	heme oxygenase 2	Homo sapiens	134-137
23332069-4	2013	Constrained water of hh cyt c is observed at every pH as an ~5-GHz Debye component (DC) (DR time, tau(D) ~30 ps) and its DR amplitude (DRA) is increased by 77% upon N-to-U(A) transition, when pH changes from 6.0 to 2.0.	Water	12-17	MHC class II DR alpha chain	Equus caballus	135-138
16382016-1	2006	Ingestion of a salty meal induces secretion of guanylin (GN) and uroguanylin (UGN) into the intestinal lumen, where they inhibit Na+ absorption and induce Cl-, HCO3-, and water secretion.	Water	171-176	guanylate cyclase activator 2b (retina)	Mus musculus	65-76
16382016-1	2006	Ingestion of a salty meal induces secretion of guanylin (GN) and uroguanylin (UGN) into the intestinal lumen, where they inhibit Na+ absorption and induce Cl-, HCO3-, and water secretion.	Water	171-176	guanylate cyclase activator 2b (retina)	Mus musculus	78-81
23332069-5	2013	Even in the N state, the DRA of the constrained-water component is found to be increased by 22% with decreasing pH from 6.0 to 2.9, suggesting an increase in the accessible surface area of native hh cyt c. Moreover, hypermobile water around native hh cyt c is detected at pH 6.0 as a 19-GHz DC (tau(D) ~ 8.4 ps &lt;tau(DW) = 9.4 ps), but is not found at other pH values.	Water	48-53	MHC class II DR alpha chain	Equus caballus	25-28
23332069-5	2013	Even in the N state, the DRA of the constrained-water component is found to be increased by 22% with decreasing pH from 6.0 to 2.9, suggesting an increase in the accessible surface area of native hh cyt c. Moreover, hypermobile water around native hh cyt c is detected at pH 6.0 as a 19-GHz DC (tau(D) ~ 8.4 ps &lt;tau(DW) = 9.4 ps), but is not found at other pH values.	Water	228-233	MHC class II DR alpha chain	Equus caballus	25-28
23332069-6	2013	The DRA signal of constrained water is found to return to the pH 2.9 (N-state) level upon U(A)-to-A transition.	Water	30-35	MHC class II DR alpha chain	Equus caballus	4-7
24429815-4	2013	Cell exposure to solutions containing NH3/NH4(+) elicits changes in intracellular pH (pHi), which can in turn affect cell water volume (CWV) by activating transport mechanisms that produce net gain or loss of solutes and water.	Water	122-127	glucose-6-phosphate isomerase	Homo sapiens	86-89
16469632-7	2006	MBC increased from 215.6 +/- 58.8 cc to 338.3 +/- 98.4 cc (p &lt; 0.01), MDP decreased from 43 +/- 13.7 cm H2O to 21.6 +/- 10.5 cm H2O (p &lt; 0.01) and compliance increased from 5.2 +/- 2.6 ml/cm H2O to 13 +/- 6.9 ml/cm H2O (p &lt; 0.01).	Water	107-110	dipeptidase 1	Homo sapiens	73-76
24429815-4	2013	Cell exposure to solutions containing NH3/NH4(+) elicits changes in intracellular pH (pHi), which can in turn affect cell water volume (CWV) by activating transport mechanisms that produce net gain or loss of solutes and water.	Water	221-226	glucose-6-phosphate isomerase	Homo sapiens	82-84
24429815-4	2013	Cell exposure to solutions containing NH3/NH4(+) elicits changes in intracellular pH (pHi), which can in turn affect cell water volume (CWV) by activating transport mechanisms that produce net gain or loss of solutes and water.	Water	221-226	glucose-6-phosphate isomerase	Homo sapiens	86-89
24033947-2	2013	Ang II type 1 receptor (AT1R) played important roles in hypertension since it binds with Ang II, controlling salt-water and blood pressure homeostasis.	Water	114-119	angiotensin II receptor, type 1a	Rattus norvegicus	0-22
16497074-0	2006	Hydration structure of water confined between mica surfaces.	Water	23-28	MHC class I polypeptide-related sequence A	Homo sapiens	46-50
16375918-9	2006	Thus, to obtain a new compound with higher inhibitory activities against AMF, water molecules at the inhibitor binding site of AMF should be replaced by a functional group of inhibitors in order to introduce direct interactions with the protein surface.	Water	78-83	glucose-6-phosphate isomerase 1	Mus musculus	73-76
16375918-9	2006	Thus, to obtain a new compound with higher inhibitory activities against AMF, water molecules at the inhibitor binding site of AMF should be replaced by a functional group of inhibitors in order to introduce direct interactions with the protein surface.	Water	78-83	glucose-6-phosphate isomerase 1	Mus musculus	127-130
24033947-2	2013	Ang II type 1 receptor (AT1R) played important roles in hypertension since it binds with Ang II, controlling salt-water and blood pressure homeostasis.	Water	114-119	angiotensin II receptor, type 1a	Rattus norvegicus	24-28
23728326-7	2013	When the alkyl chain length of 2C(n)Lac increases to 14, premicellar formation occurs in the solution along with adsorption at the air-water interface at concentrations below the cmc.	Water	135-140	lactase	Homo sapiens	36-39
23728327-2	2013	When a small amount of water was added to mixtures of CnEm and bmimPF6, two breaking points (cac1, cac2) were observed in the surface tension/CnEm concentration plots, suggesting the formation of two kinds of aggregates.	Water	23-28	transmembrane protein 54	Homo sapiens	93-97
23728327-5	2013	These results, together with freeze-fracture TEM observations, showed that the aggregate formed at cac1 was water in bmimPF6 emulsions, which then transformed to micelles solubilizing water in the palisade layer above cac2.	Water	108-113	transmembrane protein 54	Homo sapiens	99-103
16182444-1	2006	This study investigated the decolorization of the Reactive Red 2 in water using advanced oxidation processes (AOPs): UV/TiO2, UV/SnO2, UV/TiO2+SnO2, O3, O3+MnO2, UV/O3 and UV/O3+TiO2+SnO2.	Water	68-73	adenosine deaminase RNA specific B2 (inactive)	Homo sapiens	59-64
23728327-5	2013	These results, together with freeze-fracture TEM observations, showed that the aggregate formed at cac1 was water in bmimPF6 emulsions, which then transformed to micelles solubilizing water in the palisade layer above cac2.	Water	184-189	transmembrane protein 54	Homo sapiens	99-103
23225065-1	2013	BACKGROUND AND OBJECTIVES: Nd:YAP laser emitting at 1,342 nm appears promising for nonablative skin rejuvenation treatment, based on favorable absorption properties of water and melanin in this part of the spectrum.	Water	168-173	Yes1 associated transcriptional regulator	Homo sapiens	30-33
16449479-3	2006	METHOD: Changes in regional cerebral blood flow (rCBF) were measured with [(15)O]water positron emission tomography after induction of transient sadness in nine euthymic lithium responders and nine healthy siblings.	Water	81-86	CCAAT/enhancer binding protein zeta	Rattus norvegicus	49-53
23041223-2	2012	Salvianolic acid B (SA-B) is one of water soluble compounds derived from Salvia miltiorrhiza Bunge (Danshen in Chinese) widely used for chronic liver diseases.	Water	36-41	SH3-domain binding protein 5	Rattus norvegicus	20-24
16440060-5	2006	Replacement of corticosterone in the drinking water of Pomc mice recapitulated the hyperphagia, excess weight gain and fat accumulation, and hyperleptinemia characteristic of genetically rescued PomcTg mice.	Water	46-51	pro-opiomelanocortin-alpha	Mus musculus	55-59
23244755-0	2012	A water extract of Samchulkunbi-tang attenuates airway inflammation by inhibiting inos and MMP-9 activities in an ovalbumin-induced murine asthma model.	Water	2-7	matrix metallopeptidase 9	Mus musculus	91-96
16203122-2	2006	By transferring the magnetization of the labeled protein (13)C to lipid and water protons for detection, the CHH experiment reduces the time of the original 2D (13)C-detected experiment by two orders of magnitude.	Water	76-81	RNA component of mitochondrial RNA processing endoribonuclease	Homo sapiens	109-112
22885368-6	2012	In addition, comparison of the outputs of the fuzzy-based proposed index proposed with those of the NSF water quality index (the WQI) and Canadian Water Quality Index (CWQI) showed similar results and were sensitive to changes in the level of water quality parameters.	Water	104-109	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	100-103
16401133-2	2006	Particles form a monolayer on a water surface in a Langmuir trough, and according to in situ spectroscopic measurements, the surface plasmon resonance, SPR, band undergoes a blue-shift during the monolayer compression.	Water	32-37	sepiapterin reductase	Homo sapiens	152-155
22885368-6	2012	In addition, comparison of the outputs of the fuzzy-based proposed index proposed with those of the NSF water quality index (the WQI) and Canadian Water Quality Index (CWQI) showed similar results and were sensitive to changes in the level of water quality parameters.	Water	243-248	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	100-103
23089061-0	2012	Using slow-release permanganate candles to remediate PAH-contaminated water.	Water	70-75	phenylalanine hydroxylase	Homo sapiens	53-56
16471509-4	2006	The hollow Pt nanospheres, together with the predecessor Ag-Pt core-shell particles of the same size, were transferred from water to toluene and surface modified by dodecylamine in toluene.	Water	124-129	angiopoietin 1	Homo sapiens	57-62
23089061-6	2012	Results showed most of the 16 PAHs tested were degraded within 2-4 h. Using (14)C-labled phenanthrene and benzo(a)pyrene, we demonstrated that the wax matrix of the candle initially adsorbs the PAH, but then releases the PAH back into solution as transformed, more water soluble products.	Water	265-270	phenylalanine hydroxylase	Homo sapiens	30-33
23089061-6	2012	Results showed most of the 16 PAHs tested were degraded within 2-4 h. Using (14)C-labled phenanthrene and benzo(a)pyrene, we demonstrated that the wax matrix of the candle initially adsorbs the PAH, but then releases the PAH back into solution as transformed, more water soluble products.	Water	265-270	phenylalanine hydroxylase	Homo sapiens	194-197
23127123-4	2012	We find that water molecules lose at most 1/35 of their liquid entropy in mixtures.	Water	13-18	chromosome 8 putative open reading frame 17	Homo sapiens	37-43
17946437-1	2006	The purpose is to investigate the cervical spinal cord mapping on electrical stimulation at LI4 (Hegu) by using "signal enhancement by extravascular water protons" (SEEP)-fMRI, and to establish the response of acupoint-stimulation in spinal cord.	Water	149-154	lipase family member N	Homo sapiens	92-95
23176612-1	2012	In a mixed solvent of water and ethanol, polystyrene/titanium dioxide (PSt/TiO2) composite particles of core-shell structure were prepared by hydrolysis of tetrabutyl titanate in the presence of cationic PSt particles or anionic PSt particles surface-treated using gamma-aminopropyl triethoxysilane.	Water	22-27	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	71-74
16800153-1	2006	Novel partially biodegradable, temperature- and pH-sensitive polysaccharide-based hydrogels (NDF) were synthesized from modified dextran (dextran-maleic acid, Dex-MA) and N-isopropylacrylamide precursors over a wide range of mixed solvent ratios of dimethyl formamide (DMF) to water.	Water	277-282	neuregulin 1	Homo sapiens	93-96
23014263-0	2012	Cooperativity between hydrogen bonds and beryllium bonds in (H2O)(n)BeX2 (n = 1-3, X = H, F) complexes.	Water	61-64	brain expressed X-linked 2	Homo sapiens	68-72
16332873-2	2005	Alkaline, sulfidic, 54 to 60 degrees C, 4 to 53 million-year-old meteoric water emanating from a borehole intersecting quartzite-hosted fractures &gt;3.3 km beneath the surface supported a microbial community dominated by a bacterial species affiliated with Desulfotomaculum spp.	Water	74-79	histocompatibility minor 13	Homo sapiens	275-278
16272281-6	2005	Surprisingly, TLR2-/-, TLR4-/-, and TLR9-/- mice were fully susceptible to EAU and had unaltered adaptive responses to interphotoreceptor retinoid-binding protein.	Water	75-78	toll-like receptor 2	Mus musculus	14-18
22967089-5	2012	SF-GP conjugates having a very high content of GP formed completely water-soluble brush-like polymer that displayed very high affinity toward the lectin concanavalin-A (Con-A).	Water	68-73	hemocytin	Bombyx mori	146-152
23125098-0	2012	Glucocorticoid mediates water avoidance stress-sensitized colon-bladder cross-talk via RSK2/PSD-95/NR2B in rats.	Water	24-29	discs large MAGUK scaffold protein 4	Rattus norvegicus	92-98
16126304-7	2005	Tracer tests indicate that hydraulic performance deteriorated: the flow distribution was heterogeneous and under the influence of interfacial cementation a large portion of water was diverted around the Fe0 and transported outside the PRB.	Water	173-178	RB transcriptional corepressor 1	Homo sapiens	235-238
22750290-3	2012	Here we found that a water-soluble pyrrolidinium fullerene derivative, C(60)-bis (N, N-dimethylpyrrolidinium iodide), markedly induced apoptosis of JAK2 V617F mutant-induced transformed cells through a novel mechanism, inhibiting c-Jun N-terminal kinase (JNK) activation pathway but not generation of reactive oxygen species (ROS).	Water	21-26	Janus kinase 2	Homo sapiens	148-152
16182260-6	2005	[D-Arg1]AngIII produced a dose-dependent increase in water intake, whereas saline intake was equivalently increased by the 125 and 1250 pmol infusions.	Water	53-58	arginase 1	Rattus norvegicus	3-7
22706515-2	2012	We previously demonstrated the presence of ESBL-producing Enterobacteriaceae in sachet-packaged water bags sold in Kinshasa, the Democratic Republic of the Congo.	Water	96-101	CTX-M-15	Klebsiella pneumoniae	43-47
22706515-3	2012	In complement to the previous study, we aimed to assess the presence of ESBL-producing Enterobacteriaceae in waste waters in Kinshasa.Enterobacteriaceae isolates recovered from environmental water samples were screened and phenotypically confirmed as ESBL-producers by disk diffusion according to Clinical and Laboratory Standards Institute (CLSI) guidelines (CLSI M100-S21).	Water	115-120	CTX-M-15	Klebsiella pneumoniae	72-76
15912357-0	2005	Enhanced ferredoxin-dependent cyclic electron flow around photosystem I and alpha-tocopherol quinone accumulation in water-stressed ndhB-inactivated tobacco mutants.	Water	117-122	ndhB	Nicotiana tabacum	132-136
22867023-2	2012	Hence, the potential of a new water-soluble GPx mimic, DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)) in healing the indomethacin-induced stomach ulceration in mice was examined.	Water	30-35	peroxiredoxin 6 pseudogene 2	Mus musculus	44-47
22863679-4	2012	Intrahippocampal gene transfer of F-spondin improved spatial learning/memory in the Morris Water Maze and increased exploration of the novel object in the Novel Object Recognition test in wild-type mice.	Water	91-96	spondin 1, (f-spondin) extracellular matrix protein	Mus musculus	34-43
16024031-5	2005	The water adsorption increases with increasing S(BET) value; however, the opposite effect is observed for the content of surface hydroxyls (in mmol/m2).	Water	4-9	delta/notch like EGF repeat containing	Homo sapiens	49-52
22885233-3	2012	Muscimol (0.20, 0.35 or 0.50 nmol, in 0.2mul) that was injected bilaterally into the CeA decreased the 0.3M NaCl and water intake in a dose-dependent manner.	Water	117-122	carcinoembryonic antigen gene family 4	Rattus norvegicus	85-88
15896194-0	2005	NMR structural analysis of a peptide mimic of the bridging sheet of HIV-1 gp120 in methanol and water.	Water	96-101	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	74-79
22885233-5	2012	The inhibitory effect of muscimol (0.20 nmol) on the sodium and water intake could be blocked by pretreatment with bicuculline intra-CeA microinjection (0.4 nmol).	Water	64-69	carcinoembryonic antigen gene family 4	Rattus norvegicus	133-136
22795950-2	2012	In this work, water soluble plant protease inhibitor (PI), well characterized for its activity against insect pests, was incorporated into a BCME system and explored for permeation on hydrophobic leaf surfaces and protease inhibition activity.	Water	14-19	serpin family A member 13, pseudogene	Homo sapiens	34-52
16279736-5	2005	Water sorption rates also differed significantly (p &lt; 0.05)--namely 3.0 and 2.8 mg/cm2 for SLM-1 after one day and three months respectively, and 2.0 and 2.2 mg/cm2 for SLM-2.	Water	0-5	KH RNA binding domain containing, signal transduction associated 3	Homo sapiens	172-177
22795950-2	2012	In this work, water soluble plant protease inhibitor (PI), well characterized for its activity against insect pests, was incorporated into a BCME system and explored for permeation on hydrophobic leaf surfaces and protease inhibition activity.	Water	14-19	serpin family A member 13, pseudogene	Homo sapiens	54-56
22795950-4	2012	The PI was soluble in the water-rich bicontinuous domains, stable in the microemulsions, and protease inhibition activity was retained for a prolonged duration.	Water	26-31	serpin family A member 13, pseudogene	Homo sapiens	4-6
22759395-5	2012	Ethyl pyruvate (EP) treatment blocked H(2)O(2) (oxidative stress)-induced HMGB1 release from human umbilical vein endothelial cells in vitro, and in vivo resulted in nuclear retention and significant blunting of HMGB1 release into the circulation after IRI.	Water	38-43	high mobility group box 1	Homo sapiens	74-79
16146528-8	2005	MDAR activity in isolated Arabidopsis peroxisomes was distributed among both water-soluble matrix and KCl-insoluble membrane subfractions that contained respectively 47- and 54-kDa MDAR polypeptides.	Water	77-82	monodehydroascorbate reductase	Arabidopsis thaliana	0-4
22759395-5	2012	Ethyl pyruvate (EP) treatment blocked H(2)O(2) (oxidative stress)-induced HMGB1 release from human umbilical vein endothelial cells in vitro, and in vivo resulted in nuclear retention and significant blunting of HMGB1 release into the circulation after IRI.	Water	38-43	high mobility group box 1	Homo sapiens	212-217
16329776-2	2005	Aim of this study is to report an initial series of patients affected by HCC treated by hepatic resection utilizing a new water-cooled, high-density, monopolar device, the Tissuelink Monopolar Floating Ball (Tissuelink Medical Inc., Dover, NH, U.S.A.), in order to avoid bleeding during hepatic surgery.	Water	122-127	HCC	Homo sapiens	73-76
26605715-0	2012	Two Dimensional Epitaxial Water Adlayer on Mica with Graphene Coating: An ab Initio Molecular Dynamics Study.	Water	26-31	MHC class I polypeptide-related sequence A	Homo sapiens	43-47
16483542-4	2006	When assayed by a FITC-labeled dextran transepithelial flux, the increased permeability of the RPE barrier (induced by H(2)O(2)) was prevented by PEDF pretreatment.	Water	119-124	serpin family F member 1	Homo sapiens	146-150
15962356-3	2005	In contrast, compounds with different acyloxy groups at C-8 fragment by means of elimination of the corresponding carboxylic acids [M + H - (R(2)CO(2)H)](+) and consecutive losses of CO and H(2)O.	Water	190-195	homeobox C8	Homo sapiens	56-59
16722278-1	2006	The aim of this study is to assess the difference in duration of action after infiltration anesthesia when elevation of a periosteal flap (EPF) was accomplished with water or saline irrigation versus nonelevation of a periosteal flap (NEPF).	Water	166-171	heat shock protein family E (Hsp10) member 1	Homo sapiens	139-142
26605715-1	2012	Motivated by a recent atomic-force-microscopy (AFM) study of water adlayers on mica by Heath and co-workers (Graphene Visualizes the First Water Adlayers on Mica at Ambient Conditions.	Water	61-66	MHC class I polypeptide-related sequence A	Homo sapiens	79-83
15979170-9	2005	Two genes (CC8 and CC9) were induced by cold stress and 5 genes (CCII, CC3, CC4, CC5 and CC9) were down-regulated in response to water starvation.	Water	129-134	cystatin 4	Zea mays	76-79
16213559-3	2006	Results from this study indicate that cis- and trans-DCE were readily degraded to varying degrees by natural microbial populations in all the soil and water samples tested, with up to 44% of cis-DCE and 41% of trans-DCE degraded in the untreated soil and water samples in two weeks.	Water	151-156	24-dehydrocholesterol reductase	Homo sapiens	53-56
26605715-1	2012	Motivated by a recent atomic-force-microscopy (AFM) study of water adlayers on mica by Heath and co-workers (Graphene Visualizes the First Water Adlayers on Mica at Ambient Conditions.	Water	61-66	MHC class I polypeptide-related sequence A	Homo sapiens	157-161
16213559-7	2006	In addition, the results clearly demonstrate that while naturally occurring microorganisms are capable of aerobic biodegradation of cis- and trans-DCE, biotransformation may be affected by several factors, including isomer structure, soil type, and the amount of nutrients available in the water and soil.	Water	290-295	24-dehydrocholesterol reductase	Homo sapiens	147-150
26605715-1	2012	Motivated by a recent atomic-force-microscopy (AFM) study of water adlayers on mica by Heath and co-workers (Graphene Visualizes the First Water Adlayers on Mica at Ambient Conditions.	Water	139-144	MHC class I polypeptide-related sequence A	Homo sapiens	79-83
26605715-1	2012	Motivated by a recent atomic-force-microscopy (AFM) study of water adlayers on mica by Heath and co-workers (Graphene Visualizes the First Water Adlayers on Mica at Ambient Conditions.	Water	139-144	MHC class I polypeptide-related sequence A	Homo sapiens	157-161
16508658-1	2006	Aquaporin-1 (AQP1) water channels are expressed widely in microvascular endothelia outside of the central nervous system, including renal vasa recta and tumor microvessels, as well as in non-vascular endothelia in pleura, peritoneum, cornea, and lymphatics.	Water	19-24	aquaporin 1	Mus musculus	0-11
26605715-2	2012	Science2010, 329, 1188), we performed an ab initio molecular dynamics study of structural and dynamic properties of monolayer, bilayer, and trilayer water adlayers on the muscovite mica (001) surface with and without a graphene coating.	Water	149-154	MHC class I polypeptide-related sequence A	Homo sapiens	181-185
16508658-1	2006	Aquaporin-1 (AQP1) water channels are expressed widely in microvascular endothelia outside of the central nervous system, including renal vasa recta and tumor microvessels, as well as in non-vascular endothelia in pleura, peritoneum, cornea, and lymphatics.	Water	19-24	aquaporin 1	Mus musculus	13-17
26605715-3	2012	We find that in the first epitaxial water adlayer, water molecules that form strong hydrogen bonds with the oxygen on the mica surface show little motions, thereby solid-like, while those "bridging" water molecules on top of the first water adlayer exhibit "itinerant" behavior, thereby liquid-like.	Water	36-41	MHC class I polypeptide-related sequence A	Homo sapiens	122-126
16508658-2	2006	In kidney, AQP1-facilitated water transport in outer medullary descending vasa recta is likely an important component of the urinary concentrating mechanism.	Water	28-33	aquaporin 1	Mus musculus	11-15
16508658-6	2006	AQP1 facilitates endothelial cell migration by a mechanism that may involve facilitated water transport across cell protrusions (lamellipodia).	Water	88-93	aquaporin 1	Mus musculus	0-4
16012037-1	2005	CONCLUSIONS: Our results indicate that the electrogenic kidney Na(+)/HCO(3)(-) cotransporter (kNBC), KCl cotransporter (KCC1 and -4) and Ca(2+)-activated Cl(-) channel (CaCC1, -2, -3) mRNAs are expressed in normal nasal mucosa and nasal polyp, suggesting that altered expression of all CaCC mRNAs in nasal polyp may cause impaired electrolyte and water transport across the epithelial cells.	Water	347-352	chloride channel accessory 1	Homo sapiens	169-174
26605715-3	2012	We find that in the first epitaxial water adlayer, water molecules that form strong hydrogen bonds with the oxygen on the mica surface show little motions, thereby solid-like, while those "bridging" water molecules on top of the first water adlayer exhibit "itinerant" behavior, thereby liquid-like.	Water	51-56	MHC class I polypeptide-related sequence A	Homo sapiens	122-126
26605715-3	2012	We find that in the first epitaxial water adlayer, water molecules that form strong hydrogen bonds with the oxygen on the mica surface show little motions, thereby solid-like, while those "bridging" water molecules on top of the first water adlayer exhibit "itinerant" behavior, thereby liquid-like.	Water	51-56	MHC class I polypeptide-related sequence A	Homo sapiens	122-126
26605715-3	2012	We find that in the first epitaxial water adlayer, water molecules that form strong hydrogen bonds with the oxygen on the mica surface show little motions, thereby solid-like, while those "bridging" water molecules on top of the first water adlayer exhibit "itinerant" behavior, thereby liquid-like.	Water	51-56	MHC class I polypeptide-related sequence A	Homo sapiens	122-126
15849248-1	2005	The results of extended (80-ns) molecular dynamics simulations of wild-type and YQR triple mutant of sperm whale deoxy myoglobin in water are reported and compared with the results of the simulation of the intermediate(s) obtained by photodissociation of CO in the wild-type protein.	Water	132-137	myoglobin	Physeter catodon	119-128
26605715-4	2012	Overall, the Born-Oppenheim molecular dynamics (BOMD) simulations (based on the BLYP-D functional) show that the first water adlayer on mica exhibits a unique hybrid solid-liquid-like behavior with a very low diffusion coefficient at ambient conditions.	Water	119-124	MHC class I polypeptide-related sequence A	Homo sapiens	136-140
15849248-4	2005	In wild-type deoxy myoglobin, the passage between the distal pocket and the solvent is strictly correlated to the presence/absence of a water molecule that simultaneously interacts with the distal histidine side chain and the heme iron; conversely, in the photodissociated myoglobin, the connection with the bulk solvent is always open when CO is in the vicinity of the A pyrrole ring.	Water	136-141	myoglobin	Physeter catodon	19-28
15849248-4	2005	In wild-type deoxy myoglobin, the passage between the distal pocket and the solvent is strictly correlated to the presence/absence of a water molecule that simultaneously interacts with the distal histidine side chain and the heme iron; conversely, in the photodissociated myoglobin, the connection with the bulk solvent is always open when CO is in the vicinity of the A pyrrole ring.	Water	136-141	myoglobin	Physeter catodon	273-282
16476579-0	2006	Impaired pain sensation in mice lacking Aquaporin-1 water channels.	Water	52-57	aquaporin 1	Mus musculus	40-51
26605715-8	2012	Most importantly, the bilayer water adlayer on mica with the graphene coating becomes fully solid-like, the structure of which is the same as the bilayer slice of ice-Ih with a thickness of 7.4 A, consistent with the AFM measurement.	Water	30-35	MHC class I polypeptide-related sequence A	Homo sapiens	47-51
16476579-1	2006	Aquaporin-1 (AQP1), a membrane water channel, is expressed in choroid plexus where it contributes to cerebrospinal fluid production.	Water	31-36	aquaporin 1	Mus musculus	0-11
16476579-1	2006	Aquaporin-1 (AQP1), a membrane water channel, is expressed in choroid plexus where it contributes to cerebrospinal fluid production.	Water	31-36	aquaporin 1	Mus musculus	13-17
23037534-4	2012	Under the visible light illumination and a bias voltage below 1.2 V, the Mn-doped GaN photoelectrodes could drive the water splitting reaction for hydrogen generation.	Water	118-123	gigaxonin	Homo sapiens	82-85
16526652-4	2006	We predict that when the HO2 concentration is on the order of 10(8) molecules x cm(-3) at 298 K, that the number of HO2...H2O complexes is on the order of 10(7) molecules x cm(-3) and the number of HO2...(H2O)2 complexes is on the order of 10(6) molecules x cm(-3).	Water	122-125	heme oxygenase 2	Homo sapiens	25-28
16526652-4	2006	We predict that when the HO2 concentration is on the order of 10(8) molecules x cm(-3) at 298 K, that the number of HO2...H2O complexes is on the order of 10(7) molecules x cm(-3) and the number of HO2...(H2O)2 complexes is on the order of 10(6) molecules x cm(-3).	Water	122-125	heme oxygenase 2	Homo sapiens	116-119
16526652-4	2006	We predict that when the HO2 concentration is on the order of 10(8) molecules x cm(-3) at 298 K, that the number of HO2...H2O complexes is on the order of 10(7) molecules x cm(-3) and the number of HO2...(H2O)2 complexes is on the order of 10(6) molecules x cm(-3).	Water	122-125	heme oxygenase 2	Homo sapiens	116-119
16526652-4	2006	We predict that when the HO2 concentration is on the order of 10(8) molecules x cm(-3) at 298 K, that the number of HO2...H2O complexes is on the order of 10(7) molecules x cm(-3) and the number of HO2...(H2O)2 complexes is on the order of 10(6) molecules x cm(-3).	Water	205-208	heme oxygenase 2	Homo sapiens	25-28
16526652-4	2006	We predict that when the HO2 concentration is on the order of 10(8) molecules x cm(-3) at 298 K, that the number of HO2...H2O complexes is on the order of 10(7) molecules x cm(-3) and the number of HO2...(H2O)2 complexes is on the order of 10(6) molecules x cm(-3).	Water	205-208	heme oxygenase 2	Homo sapiens	116-119
15718388-3	2005	In renal medulla, prostaglandins derived from cyclooxygenase-2 (COX-2) stimulate sodium and water excretion, and renal medullary COX-2 expression increases after mineralocorticoid administration.	Water	92-97	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	46-62
16526652-4	2006	We predict that when the HO2 concentration is on the order of 10(8) molecules x cm(-3) at 298 K, that the number of HO2...H2O complexes is on the order of 10(7) molecules x cm(-3) and the number of HO2...(H2O)2 complexes is on the order of 10(6) molecules x cm(-3).	Water	205-208	heme oxygenase 2	Homo sapiens	116-119
22674027-6	2012	In rats on normal-salt chow, the stimulation of renal medullary ET(B) receptor by ET(B) receptor agonist sarafotoxin 6c (S6c) causes an increase in water (3.6 +- 0.4 from baseline vs. 10.5 +- 1.3 mul/min following S6c infusion; P &lt; 0.05) and sodium excretion (0.38 +- 0.06 vs. 1.23 +- 0.17 mumol/min; P &lt; 0.05).	Water	148-153	endothelin receptor type B	Rattus norvegicus	64-69
16526652-5	2006	Using the computed abundance of HO2...H2O, we predict that, at 298 K, the bimolecular rate constant for HO2...H2O + HO2 is about 10 times that for HO2 + HO2.	Water	38-41	heme oxygenase 2	Homo sapiens	32-35
16526652-5	2006	Using the computed abundance of HO2...H2O, we predict that, at 298 K, the bimolecular rate constant for HO2...H2O + HO2 is about 10 times that for HO2 + HO2.	Water	38-41	heme oxygenase 2	Homo sapiens	104-107
16526652-5	2006	Using the computed abundance of HO2...H2O, we predict that, at 298 K, the bimolecular rate constant for HO2...H2O + HO2 is about 10 times that for HO2 + HO2.	Water	38-41	heme oxygenase 2	Homo sapiens	104-107
15718388-3	2005	In renal medulla, prostaglandins derived from cyclooxygenase-2 (COX-2) stimulate sodium and water excretion, and renal medullary COX-2 expression increases after mineralocorticoid administration.	Water	92-97	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	64-69
22674027-6	2012	In rats on normal-salt chow, the stimulation of renal medullary ET(B) receptor by ET(B) receptor agonist sarafotoxin 6c (S6c) causes an increase in water (3.6 +- 0.4 from baseline vs. 10.5 +- 1.3 mul/min following S6c infusion; P &lt; 0.05) and sodium excretion (0.38 +- 0.06 vs. 1.23 +- 0.17 mumol/min; P &lt; 0.05).	Water	148-153	endothelin receptor type B	Rattus norvegicus	82-87
16526652-5	2006	Using the computed abundance of HO2...H2O, we predict that, at 298 K, the bimolecular rate constant for HO2...H2O + HO2 is about 10 times that for HO2 + HO2.	Water	38-41	heme oxygenase 2	Homo sapiens	104-107
16526652-5	2006	Using the computed abundance of HO2...H2O, we predict that, at 298 K, the bimolecular rate constant for HO2...H2O + HO2 is about 10 times that for HO2 + HO2.	Water	38-41	heme oxygenase 2	Homo sapiens	104-107
22966077-3	2012	Insulin resistance may be diagnosed by feeding supplementary water-soluble carbohydrate (WSC) and measuring blood glucose and insulin concentrations.	Water	61-66	INS	Equus caballus	0-7
16526652-5	2006	Using the computed abundance of HO2...H2O, we predict that, at 298 K, the bimolecular rate constant for HO2...H2O + HO2 is about 10 times that for HO2 + HO2.	Water	110-113	heme oxygenase 2	Homo sapiens	32-35
16526652-5	2006	Using the computed abundance of HO2...H2O, we predict that, at 298 K, the bimolecular rate constant for HO2...H2O + HO2 is about 10 times that for HO2 + HO2.	Water	110-113	heme oxygenase 2	Homo sapiens	104-107
16526652-5	2006	Using the computed abundance of HO2...H2O, we predict that, at 298 K, the bimolecular rate constant for HO2...H2O + HO2 is about 10 times that for HO2 + HO2.	Water	110-113	heme oxygenase 2	Homo sapiens	104-107
16526652-5	2006	Using the computed abundance of HO2...H2O, we predict that, at 298 K, the bimolecular rate constant for HO2...H2O + HO2 is about 10 times that for HO2 + HO2.	Water	110-113	heme oxygenase 2	Homo sapiens	104-107
16526652-5	2006	Using the computed abundance of HO2...H2O, we predict that, at 298 K, the bimolecular rate constant for HO2...H2O + HO2 is about 10 times that for HO2 + HO2.	Water	110-113	heme oxygenase 2	Homo sapiens	104-107
16526692-7	2006	In the water-rich region the behavior of eta degrees(s), M", and alpha are more complex and reflect the presence of dispersed aggregates whose size increases with temperature and concentration.	Water	7-12	endothelin receptor type A	Homo sapiens	41-44
15895215-5	2005	The proposed method combined with a partial-least-square (PLS) treatment was tested for quantitative analysis of mixtures of four PAH in a spiked drinking water.	Water	155-160	phenylalanine hydroxylase	Homo sapiens	130-133
16020282-14	2005	Only IL-4 production was clearly associated with reduced susceptibility to EAU.	Water	75-78	interleukin 4	Rattus norvegicus	5-9
22824424-7	2012	Chlorophyll a fluorescence analyses indicate a possible lack of intact Oxygen Evolving Complexes (OECs) in MSP antisense plants, which allow access to internal non-water electron donors (e.g., ascorbate and proline) and consequently increase the Photosystem II (PSII) activity of those plants.	Water	164-169	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	107-110
15896043-7	2005	The spectra of PPHA adsorbed at boehmite/water interfaces also showed changes generally consistent with our observations for SRFA sorbed on boehmite.	Water	41-46	meprin A subunit alpha	Homo sapiens	15-19
15896043-8	2005	These observations confirm that SRFA and PPHA are predominantly adsorbed at the boehmite/water interface in an outer-sphere fashion, with minor inner-sphere adsorption complexes being formed only under quite acidic conditions.	Water	89-94	meprin A subunit alpha	Homo sapiens	41-45
15896043-9	2005	They also suggest that the positively charged boehmite/water interface stabilizes SRFA and PPHA carboxyl functional groups against protonation at lower pH.	Water	55-60	meprin A subunit alpha	Homo sapiens	91-95
16506855-3	2006	PBP consumption significantly reduced oxidative stress in the mice peritoneal macrophages (MPM): Cellular lipid peroxide content decreased by up to 42%, the reduced glutathione levels increased by up to 53%, and paraoxonase 2 lactonase activity increased by up to 50%, as compared to MPM from E degrees mice that consumed only water.	Water	327-332	dedicator of cyto-kinesis 3	Mus musculus	0-3
16507454-0	2006	The impact of diet and betel nut use on skin lesions associated with drinking-water arsenic in Pabna, Bangladesh.	Water	78-83	NUT midline carcinoma family member 1	Homo sapiens	29-32
22819841-3	2012	In contrast, exposure of cancer cells (such as HeLa and MCF7 cells) to H(2)O(2) increased CDK2 activity with no accompanying change in the PCNA level, leading to cell proliferation.	Water	71-76	cyclin dependent kinase 2	Homo sapiens	90-94
16685671-7	2006	In in-vitro experiments, when the clamp was opened and the pressure difference in the hemodialysis machine was set to 50 mmHg, water flow through SMA-SVAD reached 500 ml/min.	Water	127-132	survival of motor neuron 1, telomeric	Homo sapiens	146-149
22717889-8	2012	The repulsion between OEG-SAMs was always observed independent of solution conditions [NaCl concentration (between 0 and 1 M) and pH (between 3 and 11)] and was not observed in solution mixed with ethanol, which disrupts the three-dimensional network of the water molecules.	Water	258-263	methionine adenosyltransferase 1A	Homo sapiens	26-30
16374623-0	2006	The effect of a tightly bound water molecule on scaffold diversity in the computer-aided de novo ligand design of CDK2 inhibitors.	Water	30-35	cyclin dependent kinase 2	Homo sapiens	114-118
19791408-0	2005	Kinetics of the gas phase HO2 self-reaction: effects of temperature, pressure, water and methanol vapours.	Water	79-84	heme oxygenase 2	Homo sapiens	26-29
15887969-0	2005	Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility.	Water	82-87	epoxide hydrolase 2	Homo sapiens	42-67
16374623-1	2006	We have determined the effects that tightly bound water molecules have on the de novo design of cyclin-dependent kinase-2 (CDK2) ligands.	Water	50-55	cyclin dependent kinase 2	Homo sapiens	96-121
22695145-1	2012	A novel configuration of microbial desalination cell (MDC) packed with ion-exchange resin (R-MDC) was proposed to enhance water desalination rate.	Water	122-127	C-C motif chemokine ligand 22	Homo sapiens	54-57
16374623-1	2006	We have determined the effects that tightly bound water molecules have on the de novo design of cyclin-dependent kinase-2 (CDK2) ligands.	Water	50-55	cyclin dependent kinase 2	Homo sapiens	123-127
16374623-2	2006	In particular, we have analyzed the impact of a specific structural water molecule on the chemical diversity and binding mode of ligands generated through a de novo structure-based ligand generation method in the binding site of CDK2.	Water	68-73	cyclin dependent kinase 2	Homo sapiens	229-233
16484569-0	2006	In vitro interactions of water-soluble garlic components with human cytochromes p450.	Water	25-30	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	80-84
15802103-2	2005	Studies suggest a causal relationship between sphincter of Oddi manometry (SOM) and acute pancreatitis, presumably due to water instillation in the ductal system.	Water	122-127	grainyhead like transcription factor 3	Homo sapiens	75-78
15802103-4	2005	This conclusion is based on two pieces of evidence: The first is lack of biologic plausibility: Biologic evidence is lacking to support the hypothesis that water instillation during SOM can induce acute pancreatitis.	Water	156-161	grainyhead like transcription factor 3	Homo sapiens	182-185
22695145-1	2012	A novel configuration of microbial desalination cell (MDC) packed with ion-exchange resin (R-MDC) was proposed to enhance water desalination rate.	Water	122-127	C-C motif chemokine ligand 22	Homo sapiens	93-96
22581383-0	2012	VACM-1/cul5 expression in vascular tissue in vivo is induced by water deprivation and its expression in vitro regulates aquaporin-1 concentrations.	Water	64-69	cullin 5	Rattus norvegicus	0-6
15702343-4	2005	When swimming at speeds from 1.0 to 1.4 m s(-1), eta(F) is about 0.5, power to overcome water resistance (active body drag x v) and power to give water kinetic energy increase from 50 to 100 W, and internal mechanical power from 10 to 30 W. In the same range of speeds E increases from 600 to 1,200 W and C from 600 to 800 J m(-1).	Water	88-93	endothelin receptor type A	Homo sapiens	49-52
15702343-4	2005	When swimming at speeds from 1.0 to 1.4 m s(-1), eta(F) is about 0.5, power to overcome water resistance (active body drag x v) and power to give water kinetic energy increase from 50 to 100 W, and internal mechanical power from 10 to 30 W. In the same range of speeds E increases from 600 to 1,200 W and C from 600 to 800 J m(-1).	Water	146-151	endothelin receptor type A	Homo sapiens	49-52
16293370-1	2006	The expression of aquaporin-1 (AQP1) protein, a water channel, in the choroid plexus epithelium was examined in the rat to determine the role of AQP1 in the pathophysiology of systemic hyponatremia.	Water	48-53	aquaporin 1	Rattus norvegicus	18-29
16293370-1	2006	The expression of aquaporin-1 (AQP1) protein, a water channel, in the choroid plexus epithelium was examined in the rat to determine the role of AQP1 in the pathophysiology of systemic hyponatremia.	Water	48-53	aquaporin 1	Rattus norvegicus	31-35
22581383-0	2012	VACM-1/cul5 expression in vascular tissue in vivo is induced by water deprivation and its expression in vitro regulates aquaporin-1 concentrations.	Water	64-69	cullin 5	Rattus norvegicus	7-11
16293370-7	2006	These findings suggest that AQP1-mediated excessive water influx into the brain through the blood-cerebrospinal fluid barrier during systemic hyponatremia may elevate the intracranial pressure and result in the apoptotic brain cell death.	Water	52-57	aquaporin 1	Rattus norvegicus	28-32
22581383-7	2012	To test the hypothesis that VACM-1/cul5 may be regulated by conditions that compromise water homeostasis in vivo, we determined if 24 h of water deprivation affects VACM-1/cul5 levels or the effect of VACM-1/cul5 on AQP1.	Water	87-92	cullin 5	Rattus norvegicus	28-34
16013451-3	2005	Regular oscillatory patterns of oxygen consumption with period lengths characteristic of those observed for rates of NADH oxidation by ECTO-NOX proteins were observed to provide evidence for transfer of protons and electrons to reduce oxygen to water.	Water	245-250	tripartite motif containing 33	Homo sapiens	135-139
16686191-1	2006	PBS, a new kind of biodegradable polymers (BDPs), was used as carbon source and biofilm carrier to remove nitrate from drinking water.	Water	128-133	cholinergic receptor muscarinic 3	Homo sapiens	0-3
22581383-8	2012	VACM-1 mRNA and protein levels were significantly higher in rat mesenteric arteries, skeletal muscle and the heart ventricle but not in the heart atrium from 24-h water-deprived rats when compared to the controls.	Water	163-168	cullin 5	Rattus norvegicus	0-6
22581383-9	2012	Interestingly, 24 h of water deprivation increased modification of VACM-1 by an ubiquitin-like protein, Nedd8, essential for cullin-dependent E3 ligase activity.	Water	23-28	cullin 5	Rattus norvegicus	67-73
22641337-0	2012	Water extract of Hedyotis Diffusa Willd suppresses proliferation of             human HepG2 cells and potentiates the anticancer efficacy of low-dose 5-fluorouracil             by inhibiting the CDK2-E2F1 pathway.	Water	0-5	cyclin dependent kinase 2	Homo sapiens	195-199
16282638-2	2006	Triacylglycerol hydrolase (TGH) hydrolyzes insoluble carboxylic esters at lipid/water interfaces, although the mechanism by which the enzyme adsorbs to lipid droplets is unclear.	Water	80-85	carboxylesterase 1	Homo sapiens	0-25
16282638-2	2006	Triacylglycerol hydrolase (TGH) hydrolyzes insoluble carboxylic esters at lipid/water interfaces, although the mechanism by which the enzyme adsorbs to lipid droplets is unclear.	Water	80-85	carboxylesterase 1	Homo sapiens	27-30
16404618-2	2006	Ang II and the AT1 receptor play a critical role in the cell-signaling process responsible for the actions of renin-angiotensin system in the regulation of blood pressure, water-electrolyte homeostasis and cell growth.	Water	172-177	renin	Rattus norvegicus	110-115
15808908-4	2005	In water, 26RFa exhibits mainly a random coil conformation although the presence of a nascent helix was detected between residues 6 and 15.	Water	3-8	pyroglutamylated RFamide peptide	Homo sapiens	10-15
15782373-0	2005	Stable, water-soluble Pta-based Ru-Ag organometallic polymers.	Water	8-13	pre T cell antigen receptor alpha	Homo sapiens	22-25
22712723-3	2012	In the following, the electrospun (ES) nanofibers of PF-b-PNIPAAm-b-PNMA were prepared in pure water using a single-capillary spinneret.	Water	95-100	keratin 75	Homo sapiens	53-57
16250007-9	2006	Microinjection of E-cadherin dsRNA has resulted only 22% blastocyst rate compared to 38%-40% in water injected and uninjected controls.	Water	96-101	cadherin 1	Bos taurus	18-28
22809229-0	2012	Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster.	Water	105-110	Suppressor of variegation 3-3	Drosophila melanogaster	30-49
16432219-0	2006	Water and ligand entry in myoglobin: assessing the speed and extent of heme pocket hydration after CO photodissociation.	Water	0-5	myoglobin	Physeter catodon	26-35
16432219-7	2006	The second-order rate constants for CO and H(2)O entry into the empty distal pocket of myoglobin are markedly different, 8 x 10(7) and 2 x 10(5) M(-1).s(-1), respectively, suggesting that hydrophobic partitioning of the apolar gas from the aqueous phase into the relatively apolar protein interior lowers the free energy barrier for CO entry.	Water	43-48	myoglobin	Physeter catodon	87-96
15829221-11	2005	The brain water content and BBB permeability of G-CSF-treated group decreased in the lesioned hemispheres compared with those of ICH-only group.	Water	10-15	colony stimulating factor 3	Rattus norvegicus	48-53
16293618-7	2006	These results indicate that Shank2 is a novel NHE3 interacting protein that is involved in the fine regulation of transepithelial salt and water transport through affecting NHE3 expression and activity.	Water	139-144	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	28-34
22525098-0	2012	Catalytic mechanism of human UDP-glucose 6-dehydrogenase: in situ proton NMR studies reveal that the C-5 hydrogen of UDP-glucose is not exchanged with bulk water during the enzymatic reaction.	Water	156-161	UDP-glucose 6-dehydrogenase	Homo sapiens	29-56
15755159-2	2005	TpRu(PPh3)(CH3CN)2 PF6 (10 mol %) catalyst effected the nucleophilic addition of water, alcohols, aniline, acetylacetone, pyrroles, and dimethyl malonate to unfunctionalized enediynes under suitable conditions (100 degrees C, 12-24 h) and gave functionalized benzene products in good yields.	Water	81-86	sperm associated antigen 17	Homo sapiens	19-22
16391762-1	2006	Modelling of the first step of the deacylation reaction of benzylpenicillin in the E. coli TEM1 beta-lactamase (with B3LYP/6-31G + (d)//AM1-CHARMM22 quantum mechanics/molecular mechanics methods) shows that a mechanism in which Glu166 acts as the base to deprotonate a conserved water molecule is both energetically and structurally consistent with experimental data; the results may assist the design of new antibiotics and beta-lactamase inhibitors.	Water	279-284	TEM-1 beta-lactamase	Escherichia coli	91-110
22609249-2	2012	Classically, it binds to its intracellular mineralocorticoid receptor to induce expression of proteins influencing the reabsorption of sodium and water in the distal nephron.	Water	146-151	nuclear receptor subfamily 3 group C member 2	Homo sapiens	43-69
16390183-1	2006	This paper describes a pilot process for obtaining protein isolates from white lupin seed with improved water solubility and technofunctional properties as well as reduced thermal damage.	Water	104-109	5'-nucleotidase, cytosolic IIIA	Homo sapiens	79-84
15751989-4	2005	The calculated redox potentials for the dimer Chla (P(D1/D2)) and accessory Chla (Chl(D1/D2)) were 1.11-1.30 V relative to the normal hydrogen electrode at pH 7, which is high enough for water oxidation.	Water	187-192	leiomodin 1	Homo sapiens	54-59
15751989-4	2005	The calculated redox potentials for the dimer Chla (P(D1/D2)) and accessory Chla (Chl(D1/D2)) were 1.11-1.30 V relative to the normal hydrogen electrode at pH 7, which is high enough for water oxidation.	Water	187-192	leiomodin 1	Homo sapiens	86-91
22314869-4	2012	This new probe, 2SBPO-Casp, was synthesized by coupling a water-soluble Nile Blue derivative (2SBPO) to an aspartic acid residue.	Water	58-63	cut like homeobox 1	Homo sapiens	22-26
15735342-9	2005	The hCyPJ structure shows a conserved water molecule close to His43 and Gln52 which appears to support the solvent-assisted mechanism.	Water	38-43	peptidylprolyl isomerase like 3	Homo sapiens	4-9
16118390-3	2006	In contrast, the AS-/- mice have low blood pressure, abnormal electrolyte homeostasis (increased plasma concentrations of K+, Ca2+, and Mg2+ and decreased concentrations of HCO3(-) and Cl- but no difference in the plasma Na+ level), and disturbances in water metabolism (higher urine output, decreased urine osmolality, and impaired urine concentrating and diluting ability).	Water	253-258	cytochrome P450, family 11, subfamily b, polypeptide 2	Mus musculus	17-19
16354161-1	2006	BACKGROUND INFORMATION: We have previously showed that: (i) cholangiocytes contain AQP1 (aquaporin 1) water channels sequestered in intracellular vesicles; and (ii) upon stimulation with choleretic agonists such as secretin or dibutyryl-cAMP (dbcAMP), the AQP1 vesicles move via microtubules to the apical cholangiocyte membrane to facilitate osmotically driven, passive water movement (i.e. ductal bile secretion).	Water	102-107	aquaporin 1	Rattus norvegicus	83-87
22582115-1	2012	Prostasin is a membrane-anchored protease expressed in airway epithelium, where it stimulates salt and water uptake by cleaving the epithelial Na(+) channel (ENaC).	Water	103-108	serine protease 8	Homo sapiens	0-9
16354161-1	2006	BACKGROUND INFORMATION: We have previously showed that: (i) cholangiocytes contain AQP1 (aquaporin 1) water channels sequestered in intracellular vesicles; and (ii) upon stimulation with choleretic agonists such as secretin or dibutyryl-cAMP (dbcAMP), the AQP1 vesicles move via microtubules to the apical cholangiocyte membrane to facilitate osmotically driven, passive water movement (i.e. ductal bile secretion).	Water	102-107	aquaporin 1	Rattus norvegicus	89-100
16354161-1	2006	BACKGROUND INFORMATION: We have previously showed that: (i) cholangiocytes contain AQP1 (aquaporin 1) water channels sequestered in intracellular vesicles; and (ii) upon stimulation with choleretic agonists such as secretin or dibutyryl-cAMP (dbcAMP), the AQP1 vesicles move via microtubules to the apical cholangiocyte membrane to facilitate osmotically driven, passive water movement (i.e. ductal bile secretion).	Water	102-107	aquaporin 1	Rattus norvegicus	256-260
16319186-1	2006	Aquaporin-1 (AQP1) is the principal water-transporting protein in cell plasma membranes in kidney proximal tubule, where it facilitates transepithelial water transport.	Water	36-41	aquaporin 1	Mus musculus	0-11
16319186-1	2006	Aquaporin-1 (AQP1) is the principal water-transporting protein in cell plasma membranes in kidney proximal tubule, where it facilitates transepithelial water transport.	Water	36-41	aquaporin 1	Mus musculus	13-17
16319186-1	2006	Aquaporin-1 (AQP1) is the principal water-transporting protein in cell plasma membranes in kidney proximal tubule, where it facilitates transepithelial water transport.	Water	152-157	aquaporin 1	Mus musculus	0-11
16319186-1	2006	Aquaporin-1 (AQP1) is the principal water-transporting protein in cell plasma membranes in kidney proximal tubule, where it facilitates transepithelial water transport.	Water	152-157	aquaporin 1	Mus musculus	13-17
16319186-4	2006	Cell cultures from AQP1 null mice were indistinguishable from those of wild-type mice in their appearance, growth/proliferation, and adhesiveness, although, as expected, they had reduced plasma membrane water permeability.	Water	203-208	aquaporin 1	Mus musculus	19-23
16319186-7	2006	Adenoviral-mediated expression of AQP1 in the AQP1-deficient cells, which increased their water permeability to that of wild-type cells, corrected their migration defect.	Water	90-95	aquaporin 1	Mus musculus	34-38
16319186-7	2006	Adenoviral-mediated expression of AQP1 in the AQP1-deficient cells, which increased their water permeability to that of wild-type cells, corrected their migration defect.	Water	90-95	aquaporin 1	Mus musculus	46-50
16737633-13	2006	A primary and single booster immunisation of ewes with a BMP15 peptide in a water-based adjuvant has led to 19-40% increases in lambs born per ewe lambing.	Water	76-81	bone morphogenetic protein 15	Ovis aries	57-62
16126234-0	2005	The stable aryl hydrocarbon receptor agonist potency of United Kingdom Continental Shelf (UKCS) offshore produced water effluents.	Water	114-119	aryl hydrocarbon receptor	Homo sapiens	11-36
16126234-1	2005	The in vitro aryl hydrocarbon receptor (AhR) agonist potency of offshore produced water effluents, collected from the United Kingdom Continental Shelf, was determined using the dioxin responsive (DR)-chemically activated luciferase expression (CALUX) assay.	Water	82-87	aryl hydrocarbon receptor	Homo sapiens	13-38
16126234-1	2005	The in vitro aryl hydrocarbon receptor (AhR) agonist potency of offshore produced water effluents, collected from the United Kingdom Continental Shelf, was determined using the dioxin responsive (DR)-chemically activated luciferase expression (CALUX) assay.	Water	82-87	aryl hydrocarbon receptor	Homo sapiens	40-43
16421349-1	2005	OBJECTIVE: High water consumption has been proposed as an aid to weight control and as a means of reducing the energy density of the diet.	Water	16-21	activation induced cytidine deaminase	Homo sapiens	58-61
16386429-0	2005	Response of ascorbate peroxidase isoenzymes and ascorbate regeneration system to abiotic stresses in Cucumis sativus L. Ascorbate peroxidase (APX) isoenzymes, distributing in at least four distinct cell compartments, the chloroplastic stroma (sAPX) and thylakoid membrane (tAPX), microbody (mAPX) and cytosol (cAPX), catalyze the reduction of H(2)O(2) to water by using ascorbic acid (AsA) as specific electron donor.	Water	355-360	shroom family member 1	Mus musculus	142-145
16285745-9	2005	that DcrA would act as a redox and/or oxygen sensor, in which the ligand exchange between water and an endogenous amino acid is a trigger for signal transduction.	Water	90-95	dcrA	Desulfovibrio vulgaris str. Hildenborough	5-9
16115872-6	2005	Tyr(105) is identified as playing a key role in GTP ring opening; it is hydrogen-bonded to the zinc-activated water molecule, the latter being positioned for nucleophilic attack on the guanine C-8 atom.	Water	110-115	homeobox C8	Homo sapiens	193-196
16217780-2	2005	That parameter is the proton magnetization exchange time (tau(MEX)) between water and the proteins.	Water	76-81	zinc finger SWIM-type containing 2	Homo sapiens	62-65
16277471-1	2005	We report a robust procedure for preparing superhydrophobic hybrid films on which the advancing contact angle for water is about 165 degrees and the roll-off angle of a 10-muL water droplet is 3 +/- 1 degrees .	Water	176-181	tripartite motif containing 37	Homo sapiens	172-175
16354009-2	2005	Insulin-loaded PLGA microspheres were prepared by water-in-oil-in-water double emulsion (batch A) and solid-in-oil-in-water emulsion (batch B) methods.	Water	50-55	insulin	Oryctolagus cuniculus	0-7
16354009-2	2005	Insulin-loaded PLGA microspheres were prepared by water-in-oil-in-water double emulsion (batch A) and solid-in-oil-in-water emulsion (batch B) methods.	Water	66-71	insulin	Oryctolagus cuniculus	0-7
16221847-3	2005	To address these questions, we mapped the expression of Arc/Arg 3.1 mRNA, a neuronal activity marker, in memory retention at multiple rostrocaudal levels of the dentate gyrus, CA3, CA1, subiculum, and lateral and medial entorhinal cortices after a platform search in a water-maze spatial task at 24 h and 1 month compared with swim and naive controls.	Water	269-274	activity regulated cytoskeleton associated protein	Homo sapiens	56-67
16853442-5	2005	At the interface, the OMI+ cations retain direct contacts with the bulk IL, whereas the more hydrophilic PF6(-) anions gradually dilute in the local water micro-environment and are thus isolated from the "bulk" IL.	Water	149-154	sperm associated antigen 17	Homo sapiens	105-108
16853442-7	2005	With the [BMI][PF6] liquid, the system gradually evolves from an IL-rich to a water-rich medium, leading to an ill-defined interfacial domain with high intersolvent mixing.	Water	78-83	sperm associated antigen 17	Homo sapiens	15-18
15928212-6	2005	CD ET(A) KO mice had a modestly enhanced ability to excrete an acute, but not a chronic, water load.	Water	89-94	endothelin receptor type A	Mus musculus	3-8
16172673-1	2005	Ranging from the oxidative conversion of water to O(2) to the elegant hydroxylation of olefins and to oxidative dehydrogenation of alcohols Ru-mediated oxidations are finding increasing application due to the unique properties of this extremely versatile transition metal, whose oxidation state can vary from -II to +VIII.	Water	41-46	cytochrome c oxidase subunit 8A	Homo sapiens	317-321
15927196-4	2005	The dissipative particle dynamics (DPD) method was used to simulate the adsorption of SDBS and OAS at the oil/water interface.	Water	110-115	SPARC related modular calcium binding 1	Homo sapiens	95-98
16171326-0	2005	In deuterated water the unspecific adsorption of proteins is significantly slowed down: results of an SPR study using model organic surfaces.	Water	14-19	sepiapterin reductase	Homo sapiens	102-105
16171358-2	2005	The fullerene-containing SAMs were investigated by cyclic voltammetry and water contact angle measurements.	Water	74-79	methionine adenosyltransferase 1A	Homo sapiens	25-29
16149817-1	2005	[reaction: see text] The title reactions, in 44 wt % ethanol-water at 25.0 degrees C, exhibit slightly curved Bronsted-type plots (log kN versus pKa of amines) with slopes beta1 = 0.1-0.44 (at high pKa) and beta2 ca.	Water	61-66	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	207-212
16834200-1	2005	The mechanism of the formation of supercooled ternary H(2)SO(4)/H(2)O/HNO(3) solution (STS) droplets in the polar winter stratosphere, i.e., the uptake of nitric acid and water onto background sulfate aerosols at T &lt; 195 K, was successfully mimicked during a simulation experiment at the large coolable aerosol chamber AIDA of Forschungszentrum Karlsruhe.	Water	64-69	axin interactor, dorsalization associated	Homo sapiens	322-326
16255374-9	2005	On the other hand, the brain specific CYP46A1 enzyme is responsible for the degradation of cholesterol into a water soluble metabolite, called 24S-OH cholesterol.	Water	110-115	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	38-45
16178617-1	2005	Atomic force microscopy operating in noncontact electrostatic force mode was used to study the interaction of water with films of alkylamines and alkylsilanes on mica.	Water	110-115	MHC class I polypeptide-related sequence A	Homo sapiens	162-166
16142583-3	2005	Previous studies had shown that the level of vimentin transcript was inhibited in rat embryonic heart after maternal exposure to TCE via drinking water.	Water	146-151	vimentin	Rattus norvegicus	45-53
15664623-3	2005	Superoxide dismutase (SOD) enzymes catalyze the breakdown of superoxide into hydrogen peroxide and water and are therefore central regulators of ROS levels.	Water	99-104	Superoxide dismutase 1	Drosophila melanogaster	0-20
15664623-3	2005	Superoxide dismutase (SOD) enzymes catalyze the breakdown of superoxide into hydrogen peroxide and water and are therefore central regulators of ROS levels.	Water	99-104	Superoxide dismutase 1	Drosophila melanogaster	22-25
15889427-4	2005	Among the different methods of modifying mica surface with APTES, the water solution modifying method appears to get the best results.	Water	70-75	MHC class I polypeptide-related sequence A	Homo sapiens	41-45
15824532-6	2005	The results suggest that CSR/CSA in CHF can be treated with CPAP set at a lower pressure than the conventional method, and that CPAP at 5-8 cm H2O is often effective in eliminating CSR/CSA, improving sleep quality, and presumably maintaining cardiac function.	Water	143-146	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	185-188
16833417-3	2005	In excess chlorite concentrations the reaction stoichiometry involves the complete desulfurization of PTU to yield a urea residue and sulfate: 2ClO2- + PhN(H)CSNH2 + H2O --&gt; SO4(2-) + PhN(H)CONH2 + 2Cl- + 2H+.	Water	166-169	carbamoyl-phosphate synthase 1	Homo sapiens	152-155
16833417-3	2005	In excess chlorite concentrations the reaction stoichiometry involves the complete desulfurization of PTU to yield a urea residue and sulfate: 2ClO2- + PhN(H)CSNH2 + H2O --&gt; SO4(2-) + PhN(H)CONH2 + 2Cl- + 2H+.	Water	166-169	carbamoyl-phosphate synthase 1	Homo sapiens	187-190
15589539-5	2005	The correlation between the structure of water in the vicinity of zwitterionic telomers and the resistance of the zwitterionic telomer SAMs against the nonspecific adsorption of proteins was discussed.	Water	41-46	methionine adenosyltransferase 1A	Homo sapiens	135-139
15683235-6	2005	On the basis of our computational results as well as previously published kinetic data, we propose that the product-inhibited form of MnSOD is best described as a side-on peroxo-Mn3+ adduct possessing an axial H2O ligand.	Water	210-213	superoxide dismutase 2	Homo sapiens	134-139
15659221-6	2005	Also, H(2)O(2) induced serine (Ser)-727 phosphorylation of Stat1 but not Stat3.	Water	6-11	signal transducer and activator of transcription 1	Rattus norvegicus	59-64
15699573-2	2005	Addition of H(2)O(2) to endothelial cells decreased GFRP mRNA levels, in contrast to the increase of tetrahydrobiopterin (BH(4)) content and GTPCH mRNA levels.	Water	12-17	GTP cyclohydrolase I feedback regulator	Homo sapiens	52-56
15629568-0	2005	Thermal decomposition kinetics of the Pb0.25Ba0.75(TNR).H2O complex.	Water	56-59	tenascin R	Homo sapiens	51-54
15455189-5	2005	The introduction of the different groups induces a well-balanced stepwise-like lipo-hydrophilic character (-0.2 &lt; log D(oct./water) &lt; +1.1).	Water	128-133	plexin A2	Mus musculus	123-126
15567301-1	2005	The aim of this study was to evaluate the rate and mechanism of conversion of two water-soluble prodrugs of cyclosporine A (CsA) intended for topical delivery to the eye.	Water	82-87	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	124-127
22062649-3	2005	Fat level affected water activity, colour, total viable and lactic acid bacteria counts of the sausages.	Water	19-24	FAT atypical cadherin 1	Homo sapiens	0-3
15770929-15	2005	RESULTS: Estimating the UFSP from the sodium-associated water transport according to the method by La Milia et al.	Water	56-61	UFM1 specific peptidase 1 (inactive)	Homo sapiens	24-28
15717837-3	2005	COX-2 blockade was achieved with NS-398 (1 mg x kg(-1).day(-1) in drinking water).	Water	75-80	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	0-5
15526270-12	2004	Inhibition studies using the monoclonal anti-CD14 antibody biG14, which is known to suppress binding of lipopolysaccharide (LPS) to CD14 via binding CD14 itself, revealed that free endotoxin was indeed the major inducer of proinflammatory cytokines in the river-water samples.	Water	262-267	CD14 molecule	Homo sapiens	45-49
15564445-0	2004	Prevention of spontaneous and experimentally induced diabetes in mice with zinc sulfate-enriched drinking water is associated with activation and reduction of NF-kappa B and AP-1 in islets, respectively.	Water	106-111	jun proto-oncogene	Mus musculus	174-178
15742712-7	2004	Basement water sources are substantial predictors of indoor total fungi, MIF, and Aspergillus/Penicillium spp.	Water	9-14	histocompatibility minor 13	Homo sapiens	106-109
15538275-12	2004	CONCLUSIONS: These findings suggest that COX-2 mediated prostaglandin has an important role in the down-regulation of AQP-2 water channel level in the medullary collecting duct cells after ureteral obstruction.	Water	124-129	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	41-46
15504510-1	2004	The Oslo municipal Water and Sewage Works (VAV) intends to improve the water quality in the Alna watercourse, in particular, with regards to the biological diversity.	Water	71-76	vav guanine nucleotide exchange factor 1	Homo sapiens	43-46
16094474-2	2005	Reaction of [Re(H(2)O)(3)(CO)(3)](+)(1) with L-ser yields the complex [Re(L-ser)(2)(CO)(3)](L-2).	Water	16-21	immunoglobulin kappa variable 3-15	Homo sapiens	92-95
16085137-2	2005	Tissue specimens including liver, kidneys, spleen, lungs, heart and tumor were separately homogenized in bovine serum albumin (BSA, 40 g/l) in water.	Water	143-148	albumin	Mus musculus	112-125
16210785-4	2005	Activity assay of caspases revealed that caspase-3, -8 and -9 were activated 2 h after exposure to H(2)O(2), whereas in irradiated cells caspase-3 and -9 activation occurred 4 h after exposure but increased caspase-8 activation was not observed.	Water	99-104	caspase 8	Homo sapiens	18-26
21744056-2	2012	This form of hypertension has been commonly thought to be mediated by excess sodium and water reabsorption by the renal mineralocorticoid receptor.	Water	88-93	nuclear receptor subfamily 3 group C member 2	Homo sapiens	120-146
15802372-2	2005	In recent years, evidence has been provided for an important role of MR not only in the regulation of sodium and water homeostasis but also in cardiovascular function, neuronal fate, and adipocyte differentiation.	Water	113-118	nuclear receptor subfamily 3 group C member 2	Homo sapiens	69-71
15549791-3	2004	The reduction of three aromatic ketones, acetophenone (AF), 4-methoxyacetophenone (MAF), and 3-chloroacetophenone (CAF), by NaBH(4) was followed by UV-vis spectroscopy in reverse micellar systems of water/AOT/isooctane at 25.0 degrees C (AOT is sodium 1,4-bis-2-ethylhexylsulfosuccinate).	Water	199-204	lysine acetyltransferase 2B	Homo sapiens	115-118
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	Water	195-200	lysine acetyltransferase 2B	Homo sapiens	51-54
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	Water	217-222	lysine acetyltransferase 2B	Homo sapiens	51-54
22584602-4	2012	Upon dehydration, the BET surface area of 1 is enhanced to a value of 463 +- 36 m(2) g(-1) due to removal of coordinated water molecule.	Water	121-126	delta/notch like EGF repeat containing	Homo sapiens	22-25
15543290-0	2004	Synthesis of Ag2S quantum dots in water-in-CO2 microemulsions.	Water	34-39	angiotensin II receptor type 1	Homo sapiens	13-17
15498604-5	2004	The P. amarus derived preparations blocked the interaction of HIV-1 gp120 with its primary cellular receptor CD4 at 50% inhibitory concentrations of 2.65 (water/alcohol extract) to 0.48 microg/ml (geraniin).	Water	155-160	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	68-73
16089435-0	2005	Computational study of phosphatase activity in soluble epoxide hydrolase: high efficiency through a water bridge mediated proton shuttle.	Water	100-105	epoxide hydrolase 2	Homo sapiens	47-72
16229609-4	2005	We also found that the differences in size and hydration energy of Mg2+ and Na+ ions have strong implications for the structure and the internal energy of interlayer water.	Water	166-171	mucin 7, secreted	Homo sapiens	67-70
22645333-6	2012	Interestingly, the inflorescence stems of ait1/nrt1.2 had a lower surface temperature than those of the WT because of excess water loss from open stomata.	Water	125-130	nicotinamide riboside transporter	Saccharomyces cerevisiae S288C	47-51
16122330-6	2005	Continuum calculations using the water model demonstrate that, unlike single shock compression, multiple shock compression results in pressure-temperature conditions where the ice VIII phase is thermodynamically favored over the liquid phase.	Water	33-38	cytochrome c oxidase subunit 8A	Homo sapiens	180-184
16121712-4	2005	Animal groups were pretreated with aquaporin-1 (AQP-1) blockers or water deprived to enhance the expression of AQP-1 water channels.	Water	67-72	aquaporin 1	Mus musculus	111-116
16121712-4	2005	Animal groups were pretreated with aquaporin-1 (AQP-1) blockers or water deprived to enhance the expression of AQP-1 water channels.	Water	117-122	aquaporin 1	Mus musculus	111-116
22671585-8	2012	In kidney proximal tubules, claudin-2, claudin-10, and claudin-17 allow for paracellular reabsorption of sodium, chloride, and water.	Water	127-132	claudin 17	Homo sapiens	55-65
16079275-6	2005	AQPs facilitate cell migration, as manifested by reduced tumor angiogenesis in AQP1-knockout mice, by a mechanism that might involve facilitated water transport in lamellipodia of migrating cells.	Water	145-150	aquaporin 1	Mus musculus	79-83
15711020-6	2004	Glo-bal ischemia with or without reperfusion increased cerebral water and lactate, but decreased ATP.	Water	64-69	gulonolactone (L-) oxidase	Rattus norvegicus	0-3
23894954-5	2012	After the closure, during the late Pliocene and early Pleistocene the collision of the DAC caused an uplift of the seafloor, where water depth of 2 300m became shallow waters of less than 40m depth.	Water	131-136	arylacetamide deacetylase	Homo sapiens	87-90
15799222-1	2004	Insulin-loaded poly(lactide) (PLA) microparticles were successfully prepared by 6% w/v PLA in the organic phase, 10% w/v PVP and varied types of 5%w/v electrolytes in the continuous phase, by using a water-in-oil-in-water emulsion/ solvent extraction technique.	Water	200-205	insulin	Oryctolagus cuniculus	0-7
15799222-1	2004	Insulin-loaded poly(lactide) (PLA) microparticles were successfully prepared by 6% w/v PLA in the organic phase, 10% w/v PVP and varied types of 5%w/v electrolytes in the continuous phase, by using a water-in-oil-in-water emulsion/ solvent extraction technique.	Water	216-221	insulin	Oryctolagus cuniculus	0-7
16051393-7	2005	Tracer tests indicate that hydraulic performance deteriorated: the flow distribution was heterogeneous and under the influence of interfacial cementation a large portion of water was diverted around the Fe0 and transported outside the PRB.	Water	173-178	RB transcriptional corepressor 1	Homo sapiens	235-238
22612103-1	2012	The orientational relaxation dynamics of water confined between mica surfaces is investigated using molecular dynamics simulations.	Water	41-46	MHC class I polypeptide-related sequence A	Homo sapiens	64-68
15292263-12	2004	Thus, the Rap.RapGAP catalytic machinery compensates for the absence of a cis-Gln by a trans-Asn and for the catalytic Arg by inducing a different GTP conformation that is more prone to be attacked by a water molecule.	Water	203-208	RAP1 GTPase activating protein	Homo sapiens	14-20
16014423-7	2005	Mice given LF or LPO showed a significantly lower lung consolidation score on day 6 after infection compared with the control mice that were given water instead.	Water	147-152	lactoperoxidase	Mus musculus	17-20
22612103-2	2012	The study illustrates the wide heterogeneity that exists in the dynamics of water adjacent to a strongly hydrophilic surface such as mica.	Water	76-81	MHC class I polypeptide-related sequence A	Homo sapiens	133-137
22612103-4	2012	A 10-fold increase in the survival times is observed for water directly in contact with the mica surface and a non-monotonic variation in the survival times is observed moving away from the mica surface to the bulk-like interior.	Water	57-62	MHC class I polypeptide-related sequence A	Homo sapiens	92-96
22612103-9	2012	Unlike previously observed jump dynamics in bulk water and other surfaces, jump events in the mica contact layer occur between hydrogen bonds formed by the water molecule and acceptor oxygens on the mica surface.	Water	49-54	MHC class I polypeptide-related sequence A	Homo sapiens	94-98
15982471-6	2005	An increase in the ultrasound velocity correlated with the volumetric water loss in the tissue was observed when other tissue components (proteins, fat) remained constant.	Water	70-75	FAT atypical cadherin 1	Homo sapiens	148-151
22612103-9	2012	Unlike previously observed jump dynamics in bulk water and other surfaces, jump events in the mica contact layer occur between hydrogen bonds formed by the water molecule and acceptor oxygens on the mica surface.	Water	49-54	MHC class I polypeptide-related sequence A	Homo sapiens	199-203
15476389-11	2004	In simulations beginning with the "PrP(Sc)-like" structure (derived from PrP(C) simulated at low pH in pure water) in 1 M TMAO, similar structural reorganization at the N-terminus occurred, disrupting the extended sheet.	Water	108-113	prion protein	Mus musculus	35-38
15476389-11	2004	In simulations beginning with the "PrP(Sc)-like" structure (derived from PrP(C) simulated at low pH in pure water) in 1 M TMAO, similar structural reorganization at the N-terminus occurred, disrupting the extended sheet.	Water	108-113	prion protein	Mus musculus	73-76
22612103-9	2012	Unlike previously observed jump dynamics in bulk water and other surfaces, jump events in the mica contact layer occur between hydrogen bonds formed by the water molecule and acceptor oxygens on the mica surface.	Water	156-161	MHC class I polypeptide-related sequence A	Homo sapiens	94-98
16833996-0	2005	Formation of nitric acid in the gas-phase HO2 + NO reaction: effects of temperature and water vapor.	Water	88-93	heme oxygenase 2	Homo sapiens	42-45
22612103-9	2012	Unlike previously observed jump dynamics in bulk water and other surfaces, jump events in the mica contact layer occur between hydrogen bonds formed by the water molecule and acceptor oxygens on the mica surface.	Water	156-161	MHC class I polypeptide-related sequence A	Homo sapiens	199-203
22695858-0	2012	Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells.	Water	49-54	matrix metallopeptidase 2	Homo sapiens	58-84
16852665-1	2005	Modes of adsorption of water dimer on H-ZSM-5 and H-Faujasite (H-FAU) zeolites have been investigated by a quantum embedded cluster approach, using the hybrid B3LYP density functional theory.	Water	23-28	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	65-68
15205186-4	2004	In the present study, we have identified an aquaporin (AQP) 2 homolog water channel in the medullary cones of Japanese quail, Coturnix coturnix (qAQP2), by RT-PCR-based cloning techniques.	Water	70-75	aquaporin-2	Coturnix japonica	55-61
15713911-1	2005	Aquaporin-1 is the major protein responsible for transport of water across the epithelia of the proximal tubule and thin descending limbs.	Water	62-67	aquaporin 1	Mus musculus	0-11
21713492-3	2012	In this research, three key contaminants including suspended solid, hardness as well as COD have been considered to analyze the water network.	Water	128-133	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	88-91
15936193-0	2005	Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia.	Water	0-5	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	27-32
15936193-1	2005	A water soluble choline prodrug (17) of a COX-2 selective inhibitor (16) suitable for intravenous dosing in models of cerebral ischemia has been developed.	Water	2-7	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	42-47
22361023-2	2012	The glial water channel aquaporin-4 (AQP4) is expressed in astrocytes, and along with the inwardly-rectifying K(+) channel K(ir)4.1 is thought to underlie the reuptake of H(2)O and K(+) into glial cells during neural activity.	Water	10-15	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	123-131
15957033-1	2005	Palladium acetate immobilized on reversed phase amorphous silica gel with the aid of an ionic liquid, [bmim]PF6, was highly efficient in the promotion of the Mizoroki-Heck reaction in pure water without a ligand up to the sixth re-use, in 95% average yield with TON and TOF 1,600,000 and 71,000 (h(-1)), respectively.	Water	189-194	sperm associated antigen 17	Homo sapiens	108-111
15322894-0	2004	Bounded water kinetic model of beta-galactosidase in reverse micelles.	Water	8-13	galactosidase beta 1	Homo sapiens	31-49
15454455-3	2004	Second, at pH 1.5, the water-exposed tyrosine of either thermally or chemically unfolded UBQ decays as a sum of two exponentials.	Water	23-28	ubiquitin	Bos taurus	89-92
22361023-2	2012	The glial water channel aquaporin-4 (AQP4) is expressed in astrocytes, and along with the inwardly-rectifying K(+) channel K(ir)4.1 is thought to underlie the reuptake of H(2)O and K(+) into glial cells during neural activity.	Water	171-176	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	123-131
22210893-4	2012	Previously, water-insoluble ceramides were shown to change alternative splicing and decrease SR-protein phosphorylation by activating protein phosphatase-1 (PP1).	Water	12-17	RNA binding protein with serine rich domain 1	Homo sapiens	93-103
15351689-4	2004	We used both unmodified zebrafish embryos and those with water channels (aquaporin-3 or AQP3) inserted into their membranes to increase permeability to water and cryoprotectants, examined at 100% epiboly to the 6-somite stage.	Water	57-62	aquaporin 3a	Danio rerio	73-84
15896947-5	2005	The in situ BAM and ex situ AFM observations demonstrate that the dispersion of PLG at air/water interface becomes good when it mixes with the two cationic surfactants, whereas quite poor due to the phase separation when it mixes with the nonionic amphiphilic molecule.	Water	91-96	plasminogen	Homo sapiens	80-83
15896947-6	2005	Based on these results we conclude that the cationic surfactants can affect the conformation change of PLG at air/water interface and figure a well miscibility with polymer whereas the nonionic amphiphilic molecule presents poor miscibility.	Water	114-119	plasminogen	Homo sapiens	103-106
22381655-7	2012	Overexpression of TaEXPB23 in tobacco (tabacum) conferred tolerance to salt stress by enhancing water retention ability (WRA) and decreasing osmotic potential (OP).	Water	96-101	EXPB23	Triticum aestivum	18-26
15635659-1	2005	The peptide hormones guanylin and uroguanylin are ligands of the intestinal guanylyl cyclase-C (GC-C) that is involved in the regulation of epithelial water and electrolyte transport.	Water	151-156	guanylate cyclase 2C	Homo sapiens	76-94
15635659-1	2005	The peptide hormones guanylin and uroguanylin are ligands of the intestinal guanylyl cyclase-C (GC-C) that is involved in the regulation of epithelial water and electrolyte transport.	Water	151-156	guanylate cyclase 2C	Homo sapiens	96-100
15351655-1	2004	Aquaporin-0 (AQP0), previously known as major intrinsic protein (MIP), is the only water pore protein expressed in lens fiber cells.	Water	83-88	lens fiber major intrinsic protein	Ovis aries	0-11
15351655-1	2004	Aquaporin-0 (AQP0), previously known as major intrinsic protein (MIP), is the only water pore protein expressed in lens fiber cells.	Water	83-88	lens fiber major intrinsic protein	Ovis aries	13-17
15351655-1	2004	Aquaporin-0 (AQP0), previously known as major intrinsic protein (MIP), is the only water pore protein expressed in lens fiber cells.	Water	83-88	lens fiber major intrinsic protein	Ovis aries	40-63
15351655-1	2004	Aquaporin-0 (AQP0), previously known as major intrinsic protein (MIP), is the only water pore protein expressed in lens fiber cells.	Water	83-88	lens fiber major intrinsic protein	Ovis aries	65-68
15351655-8	2004	This change of function of AQP0 from a water pore in the cortex to an adhesion molecule in the lens core constitutes another manifestation of the gene sharing concept originally proposed on the basis of the dual function of crystallins.	Water	39-44	lens fiber major intrinsic protein	Ovis aries	27-31
16833643-0	2005	Water dependence of the HO2 self reaction: kinetics of the HO2-H2O complex.	Water	0-5	heme oxygenase 2	Homo sapiens	24-27
16833643-0	2005	Water dependence of the HO2 self reaction: kinetics of the HO2-H2O complex.	Water	0-5	heme oxygenase 2	Homo sapiens	59-62
22455998-0	2012	Optimization of methods for quantification of rCBF using high-resolution [15O]H2O PET images.	Water	78-81	CCAAT/enhancer binding protein zeta	Rattus norvegicus	46-50
16833643-0	2005	Water dependence of the HO2 self reaction: kinetics of the HO2-H2O complex.	Water	63-66	heme oxygenase 2	Homo sapiens	24-27
16833643-0	2005	Water dependence of the HO2 self reaction: kinetics of the HO2-H2O complex.	Water	63-66	heme oxygenase 2	Homo sapiens	59-62
16833643-1	2005	Transient absorption spectra and decay profiles of HO2 have been measured using cw near-IR two-tone frequency modulation absorption spectroscopy at 297 K and 50 Torr in diluent of N2 in the presence of water.	Water	202-207	heme oxygenase 2	Homo sapiens	51-54
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	77-82	heme oxygenase 2	Homo sapiens	26-29
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	77-82	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	77-82	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	77-82	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	77-82	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	77-82	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	131-134	heme oxygenase 2	Homo sapiens	26-29
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	131-134	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	131-134	heme oxygenase 2	Homo sapiens	125-128
15366919-2	2004	Upon complexation with the chiral C(60)-bisadducts, only the trans-3 bisadduct exhibited the characteristic induced circular dichroism (ICD) in the UV-visible region of the polymer backbone in dimethyl sulfoxide-water mixtures due to the predominantly one-handed helix formation of poly-1, while the trans-2 and cis-3 bisadducts induced almost no apparent CD in the same region.	Water	212-217	suppressor of cytokine signaling 3	Homo sapiens	312-317
15360238-3	2004	When compared to the results obtained in dry [BMI][PF6], the present results reveal the importance of water.	Water	102-107	sperm associated antigen 17	Homo sapiens	51-54
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	131-134	heme oxygenase 2	Homo sapiens	125-128
22455998-1	2012	This study aimed to derive accurate estimates of regional cerebral blood flow (rCBF) from noisy dynamic [15O]H2O PET images acquired on the high-resolution research tomograph, while retaining as much as possible the high spatial resolution of this brain scanner (2-3 mm) in parametric maps of rCBF.	Water	109-112	CCAAT/enhancer binding protein zeta	Rattus norvegicus	79-83
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	131-134	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	131-134	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	150-153	heme oxygenase 2	Homo sapiens	26-29
15360286-3	2004	UV irradiation of the photosensitive surface of poly(NSP-co-MMA)-coated glass plates decreased the water contact angles (11 +/- 1 degrees ) and increased diameter of a water drop relative to the unexposed surface.	Water	99-104	reticulon 1	Mus musculus	53-56
21562725-1	2012	Intramyocardial fat can be observed in different pathologic processes including arrhythmogenic right ventricular cardiomyopathy (ARVC) and in old myocardial infarction (OMI) In SSFP images, fat is hyperintense and surrounded by a black boundary, called "Indian Ink" artifact that is generated when fat and water coexist in the same voxel.	Water	306-311	FAT atypical cadherin 1	Homo sapiens	16-19
15360286-3	2004	UV irradiation of the photosensitive surface of poly(NSP-co-MMA)-coated glass plates decreased the water contact angles (11 +/- 1 degrees ) and increased diameter of a water drop relative to the unexposed surface.	Water	168-173	reticulon 1	Mus musculus	53-56
17191905-10	2004	The cytochrome c oxidase-modified electrodes described here could potentially be used for the direct electroreduction of oxygen to water in a biofuel cell.	Water	131-136	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	4-24
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	150-153	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	150-153	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	150-153	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	150-153	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	150-153	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	256-261	heme oxygenase 2	Homo sapiens	26-29
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	256-261	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	256-261	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	256-261	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	256-261	heme oxygenase 2	Homo sapiens	125-128
16833643-2	2005	From the depletion of the HO2 absorption peak area following the addition of water, the equilibrium constant of the reaction HO2 + H2O &lt;--&gt; HO2-H2O was determined to be K2 = (5.2 +/- 3.2) x 10(-19) cm3 molecule(-1) at 297 K. Substituting K2 into the water dependence of the HO2 decay rate, the rate coefficient of the reaction HO2 + HO2-H2O was estimated to be (1.5 +/- 0.1) x 10(-11) cm3 molecule(-1) s(-1) at 297 K and 50 Torr with N2 as the diluent.	Water	256-261	heme oxygenase 2	Homo sapiens	125-128
16833643-3	2005	This reaction is much faster than the HO2 self-reaction without water.	Water	64-69	heme oxygenase 2	Homo sapiens	38-41
16833643-4	2005	It is suggested that the apparent rate of the HO2 self-reaction is enhanced by the formation of the HO2-H2O complex and its subsequent reaction.	Water	104-107	heme oxygenase 2	Homo sapiens	46-49
16833643-4	2005	It is suggested that the apparent rate of the HO2 self-reaction is enhanced by the formation of the HO2-H2O complex and its subsequent reaction.	Water	104-107	heme oxygenase 2	Homo sapiens	100-103
16833643-5	2005	Results are discussed with respect to the kinetics and atmospheric chemistry of the HO2-H2O complex.	Water	88-91	heme oxygenase 2	Homo sapiens	84-87
21562725-1	2012	Intramyocardial fat can be observed in different pathologic processes including arrhythmogenic right ventricular cardiomyopathy (ARVC) and in old myocardial infarction (OMI) In SSFP images, fat is hyperintense and surrounded by a black boundary, called "Indian Ink" artifact that is generated when fat and water coexist in the same voxel.	Water	306-311	FAT atypical cadherin 1	Homo sapiens	190-193
16833643-6	2005	At 297 K and 50% humidity, the concentration ratio of [HO2-H2O]/[HO2] was estimated from the value of K2 to be 0.19 +/- 0.11.	Water	59-62	heme oxygenase 2	Homo sapiens	55-58
15261731-5	2004	Enhanced levels of total cytochromes P450 (3.4 times) and b5 (2.7 times) and activity of cytochrome c (P450) reductase (2.2 times) were observed in specimens collected near the water influx from the Billings before the pumping started.	Water	177-182	cytochrome c	Oreochromis niloticus	89-101
21562725-1	2012	Intramyocardial fat can be observed in different pathologic processes including arrhythmogenic right ventricular cardiomyopathy (ARVC) and in old myocardial infarction (OMI) In SSFP images, fat is hyperintense and surrounded by a black boundary, called "Indian Ink" artifact that is generated when fat and water coexist in the same voxel.	Water	306-311	FAT atypical cadherin 1	Homo sapiens	190-193
22356282-5	2012	Application of H(2)O(2) accelerated cell death and decreased seedling viability in atj1-1.	Water	15-20	DNAJ heat shock family protein	Arabidopsis thaliana	83-89
15288339-5	2004	Insulin formulation in chitosan solution prepared with deionized water brought to a higher relative pharmacological bioavailability (Fr) value than that prepared with 50 mM pH 7.4 phosphate buffer.	Water	65-70	insulin	Oryctolagus cuniculus	0-7
15710610-1	2005	Calmodulin plays a critical role in regulation of renal collecting duct water permeability by vasopressin.	Water	72-77	calmodulin 1	Rattus norvegicus	0-10
15815633-1	2005	Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability.	Water	24-29	aquaporin 1	Mus musculus	0-11
15815633-1	2005	Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability.	Water	24-29	aquaporin 1	Mus musculus	13-17
15815633-1	2005	Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability.	Water	120-125	aquaporin 1	Mus musculus	0-11
15815633-1	2005	Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability.	Water	120-125	aquaporin 1	Mus musculus	13-17
15815633-7	2005	Motile AQP1-expressing cells had prominent membrane ruffles at the leading edge with polarization of AQP1 protein to lamellipodia, where rapid water fluxes occur.	Water	143-148	aquaporin 1	Mus musculus	7-11
22352796-4	2012	The primary cause was traced to a single amino acid change in the binding site (EGFR position 775), involving a swap from C or S (EGFR and HER2) to V (ErbB4), for which the side chain is bulkier, is hydrophobic, and lacks the ability to form a H-bond with water.	Water	256-261	erb-b2 receptor tyrosine kinase 4	Homo sapiens	151-156
15784333-3	2005	The pH-independent solubility of the N-butanoyloxymethyl derivate exceeded 1000 mg ml-1 corresponding approximately to a 10,000-fold increase in water solubility compared to that of bupivacaine base.	Water	145-150	interleukin 17F	Homo sapiens	83-87
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	116-121	keratin 1	Homo sapiens	404-412
22339618-6	2012	The application of CXLs to more complex systems (e.g., in vivo cross-linking) is illustrated by Western blot detection of Cul1 complexes including known binders, Cand1 and Skp2, in HEK 293 cells, confirming good water solubility and cell-permeability.	Water	212-217	cullin 1	Homo sapiens	122-126
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 1	Homo sapiens	404-412
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 1	Homo sapiens	404-412
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 1	Homo sapiens	404-412
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 1	Homo sapiens	404-412
15708367-9	2005	ICL and its product appear to be sensitive to oxidative damage; thus, association of CAT with ICL would afford protection from H(2)O(2).	Water	127-132	isocitrate lyase	Ricinus communis	94-97
15727871-10	2005	This is the first report on a water-soluble pol alpha-specific inhibitor, sought for precise biochemical studies of pol alpha.	Water	30-35	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	44-53
22063720-7	2012	The efficiency of lipid dilution was dependent on StarD7 electrostatic interactions with the lipid-water interface, as shown by the pH- and salt-induced modulation.	Water	99-104	StAR related lipid transfer domain containing 7	Homo sapiens	50-56
15727871-10	2005	This is the first report on a water-soluble pol alpha-specific inhibitor, sought for precise biochemical studies of pol alpha.	Water	30-35	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	116-125
15338365-7	2004	Induction of gastric mucosal HSP72 by 6-h water-immersion stress was compared between cirrhotic and control rats.	Water	42-47	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	29-34
15338365-10	2004	Baseline expression (before water-immersion stress) of mucosal HSP72 was significantly lower in cirrhotic rats compared with control rats.	Water	28-33	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	63-68
15338365-11	2004	HCl-induced gastric mucosal lesions were significantly suppressed in control rats compared with cirrhotic rats, especially when HSP72 was preinduced by water-immersion stress.	Water	152-157	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	128-133
15732963-1	2005	[Co3(HCOO)6](CH3OH)(H2O) (1), the isostructural analogue of the porous magnet of coordination framework [Mn3(HCOO)6](CH3OH)(H2O), and its desolvated form [Co3(HCOO)6] (2) were prepared and characterized by X-ray and neutron diffraction methods, IR, thermal analyses, and BET, and their magnetic properties were measured.	Water	20-23	delta/notch like EGF repeat containing	Homo sapiens	271-274
22244837-4	2012	In this study, we found that adding 10 muM water-soluble CoQ(10) to the culture medium of clk-1 mutant nematodes that were fed a diet of standard bacteria restored the pharyngeal pumping, defecation and the lifespan to levels that were comparable to those of wild-type animals.	Water	43-48	CDC like kinase 1	Homo sapiens	90-95
16004300-2	2005	The reactor was operated for 110 days to investigate the effect of influent load, retention time and spray water on the removal of BBP and the biodegradation characteristics.	Water	107-112	transmembrane protein 158	Homo sapiens	131-134
15273299-9	2004	For PQQH--&gt;PQQH2, migration of H5 to the C4 oxygen may be assisted by a weak base like water (either by crystal water Wat97 or bulk solvent, hydrogen-bonded to Glu 171-CO2- in MDH and by Wat89 in sGDH).	Water	90-95	NADH:ubiquinone oxidoreductase subunit B5	Homo sapiens	199-203
21841825-3	2012	Here we report that H-RasV12 positively regulates the NADPH oxidase system NOX4-p22(phox) that produces H(2)O(2).	Water	104-109	NADPH oxidase 4	Homo sapiens	75-79
15010357-6	2004	The ZP120C-induced aquaresis was associated with downregulation of the aquaporin-2 protein level in both rat groups, suggesting that opioid receptor-like 1 receptor stimulation produces aquaresis by inhibiting the vasopressin type-2 receptor-mediated stimulation on collecting duct water reabsorption.	Water	282-287	opioid related nociceptin receptor 1	Rattus norvegicus	133-155
15212511-1	2004	Catalytic asymmetric Mannich-type reactions in water proceeded in high yields and selectivities using a combination of ZnF2 and a chiral diamine that has the methoxy groups on the aromatic rings.	Water	47-52	zinc finger protein 2	Homo sapiens	119-123
15574706-6	2005	Instead, two hydrophobic rings, formed by alpha4-V259, alpha4-L263, and the homologous residues in the beta2-subunits, act as the gates for water flow, even though the region has a slightly larger pore radius.	Water	140-145	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	103-108
15574706-7	2005	The model offers new insight into the water transport across the (alpha4)2(beta2)3 nAChR channel, and may lead to a better understanding of the structures, dynamics, and functions of this family of ion channels.	Water	38-43	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	75-80
15675608-1	2005	GPI-15715 (PQ-1002, Aquavan), a water-soluble prodrug of propofol, is being developed by Guilford, under license from ProQuest, as a potential anesthetic agent.	Water	32-37	glucose-6-phosphate isomerase	Homo sapiens	0-3
22264166-0	2012	Apolipoprotein C-I binds more strongly to phospholipid/triolein/water than triolein/water interfaces: a possible model for inhibiting cholesterol ester transfer protein activity and triacylglycerol-rich lipoprotein uptake.	Water	64-69	apolipoprotein C1	Homo sapiens	0-18
15533949-0	2005	Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1.	Water	96-101	aquaporin 1	Mus musculus	110-121
15533949-1	2005	Aquaporin-1 (AQP1) is a water channel expressed strongly at the ventricular-facing surface of choroid plexus epithelium.	Water	24-29	aquaporin 1	Mus musculus	0-11
22264166-3	2012	To understand apoC-I"s behavior at hydrophobic lipoprotein surfaces, oil drop tensiometry was used to compare the binding to triolein/water (TO/W) and palmitoyloleoylphosphatidylcholine/triolein/water (POPC/TO/W) interfaces.	Water	134-139	apolipoprotein C1	Homo sapiens	14-20
15533949-1	2005	Aquaporin-1 (AQP1) is a water channel expressed strongly at the ventricular-facing surface of choroid plexus epithelium.	Water	24-29	aquaporin 1	Mus musculus	13-17
15533949-3	2005	Osmotically induced water transport was rapid in choroid plexus from wild-type mice and reduced by fivefold by AQP1 deletion.	Water	20-25	aquaporin 1	Mus musculus	111-115
15512981-8	2004	Exacerbation of EAU in both CD200KO mice and Lewis rats when CD200-CD200R interaction is blocked suggests that this could be an avenue for therapeutic intervention.	Water	16-19	Cd200 molecule	Rattus norvegicus	28-33
22216882-0	2012	Reversible dewetting of a molecularly thin fluid water film in a soft graphene-mica slit pore.	Water	49-54	MHC class I polypeptide-related sequence A	Homo sapiens	79-83
15203244-7	2004	Consistent with previous data suggesting that NPY modulates water drinking, Y(2)(-/-) mice of both genetic backgrounds consume significantly more water than Y(2)(+/+) mice.	Water	60-65	neuropeptide Y	Mus musculus	46-49
15533949-5	2005	By stereotaxic puncture of the lateral ventricle with a microneedle, ICP was 9.5 +/- 1.4 cm H2O in wild-type mice and 4.2 +/- 0.4 cm H2O in AQP1 null mice.	Water	133-136	aquaporin 1	Mus musculus	140-144
22216882-3	2012	We will show in the following that a molecularly thin water film confined between mica and graphene is fluid.	Water	54-59	MHC class I polypeptide-related sequence A	Homo sapiens	82-86
16399355-7	2005	While ARSA, ARSB, and PAS are water-soluble enzymes, ES has a hydrophobic domain and is presumed to be bound to the endoplasmic reticulum membrane.	Water	30-35	arylsulfatase A	Homo sapiens	6-10
22216882-6	2012	At sufficiently high humidity a continuous molecularly thin water film wets the interface between the graphene and mica.	Water	60-65	MHC class I polypeptide-related sequence A	Homo sapiens	115-119
22195978-2	2012	The water films formed spontaneously on mica substrates in a saturation humidity environment.	Water	4-9	MHC class I polypeptide-related sequence A	Homo sapiens	40-44
15590158-11	2005	Of those responsive to tap water, 47%, 50%, and 4% exhibited immunoreactivity for Glu-, SP- and CGRP, respectively.	Water	27-32	calcitonin-related polypeptide alpha	Rattus norvegicus	82-100
15250151-4	2004	The fitted curve between water percentage and the apparent viscosity (eta) at low shear rate was steeper than the others.	Water	25-30	endothelin receptor type A	Homo sapiens	70-73
22071246-8	2012	Addition of 2.5% sodium chloride to the drinking water for 48 h induced a two- to threefold upregulation of BGT1, tonicity-responsive enhancer binding protein, and sodium-myo-inositol cotransporter 1 (slc5a3) in the renal medulla, but not in the brain and barely in the liver.	Water	49-54	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	Mus musculus	108-112
15147186-2	2004	Homodimeric CDA (D-CDA) and homotetrameric CDA (T-CDA) both contain one zinc ion per subunit coordinated to the catalytic water molecule.	Water	122-127	cytidine deaminase	Homo sapiens	12-15
15147186-2	2004	Homodimeric CDA (D-CDA) and homotetrameric CDA (T-CDA) both contain one zinc ion per subunit coordinated to the catalytic water molecule.	Water	122-127	cytidine deaminase	Homo sapiens	19-22
16123570-4	2005	RESULTS: After 24 h, the concentration of transforming growth factor-beta1 (TGF-beta1) increased under intense IPL conditions (100 and 200 cm H2O) in the 15-min IPL group (p&lt;0.05, p&lt;0.01).	Water	142-145	transforming growth factor beta-1 proprotein	Canis lupus familiaris	42-74
21843503-0	2012	Water wires in atomistic models of the Hv1 proton channel.	Water	0-5	hydrogen voltage gated channel 1	Homo sapiens	39-42
16123570-4	2005	RESULTS: After 24 h, the concentration of transforming growth factor-beta1 (TGF-beta1) increased under intense IPL conditions (100 and 200 cm H2O) in the 15-min IPL group (p&lt;0.05, p&lt;0.01).	Water	142-145	transforming growth factor beta-1 proprotein	Canis lupus familiaris	76-85
15563967-2	2004	One of the such; an extract of Commelina communis L. (CE-L) after decoction in water has been traditionally used for the treatment of diabetes in Korea.	Water	79-84	carboxyl ester lipase	Mus musculus	54-58
15147186-2	2004	Homodimeric CDA (D-CDA) and homotetrameric CDA (T-CDA) both contain one zinc ion per subunit coordinated to the catalytic water molecule.	Water	122-127	cytidine deaminase	Homo sapiens	19-22
15147186-2	2004	Homodimeric CDA (D-CDA) and homotetrameric CDA (T-CDA) both contain one zinc ion per subunit coordinated to the catalytic water molecule.	Water	122-127	cytidine deaminase	Homo sapiens	48-53
21843503-8	2012	Taken together, our results suggest that proton conduction in Hv1 may occur via Grotthuss hopping along a robust water wire, with exchange of water molecules between inner and outer ends of the permeation pathway minimized by specific water-protein interactions.	Water	113-118	hydrogen voltage gated channel 1	Homo sapiens	62-65
21843503-8	2012	Taken together, our results suggest that proton conduction in Hv1 may occur via Grotthuss hopping along a robust water wire, with exchange of water molecules between inner and outer ends of the permeation pathway minimized by specific water-protein interactions.	Water	142-147	hydrogen voltage gated channel 1	Homo sapiens	62-65
15033928-9	2004	Expression of sarcolemmal AQP4 together with that of vascular AQP1 may be responsible for the fast water transfer from the blood into the muscle during intense activity.	Water	99-104	aquaporin 1	Mus musculus	62-66
15642334-2	2004	We have shown that gelsolin (an actin-severing protein) is the major water-soluble corneal protein of the zebrafish (Danio rerio) and the "four-eyed" fish (Anableps anableps).	Water	69-74	gelsolin a	Danio rerio	19-27
21843503-8	2012	Taken together, our results suggest that proton conduction in Hv1 may occur via Grotthuss hopping along a robust water wire, with exchange of water molecules between inner and outer ends of the permeation pathway minimized by specific water-protein interactions.	Water	142-147	hydrogen voltage gated channel 1	Homo sapiens	62-65
22512178-3	2012	On this basis, coating with thin PVA film of different thickness and with capacity of adsorbing water molecule on the surface of optical fiber SPR sensor probe, for the purpose of monitoring relative humidity was proposed.	Water	96-101	sepiapterin reductase	Homo sapiens	143-146
15464792-0	2004	Use of the BET adsorption isotherm equation to examine styrene adsolubilization by nonionic surfactants at the water-silica interface.	Water	111-116	delta/notch like EGF repeat containing	Homo sapiens	11-14
15464792-1	2004	A modified BET adsorption isotherm equation was used to explain adsolubilization at the water-silica interface, producing a method for understanding adsolubilization that is independent of admicelle structure.	Water	88-93	delta/notch like EGF repeat containing	Homo sapiens	11-14
15123567-9	2004	However, AT(2)R-AS-treated rats displayed significantly reduced dipsogenic responses to both angiotensin and water deprivation.	Water	109-114	angiotensin II receptor, type 2	Rattus norvegicus	9-15
22219322-7	2012	These findings were supported by the observation that in situ activation of DC before adoptive transfer of beta-galactosidase-specific T cells dramatically increased severity and incidence of EAU.	Water	192-195	galactosidase beta 1	Homo sapiens	107-125
15521012-8	2004	When mice were treated with 3% DSS in drinking water for 6 days followed by distilled water without DSS, 72% of HGFA-deficient mice died through day 12 while 75% of control mice survived injury.	Water	47-52	hepatocyte growth factor activator	Mus musculus	112-116
15521012-8	2004	When mice were treated with 3% DSS in drinking water for 6 days followed by distilled water without DSS, 72% of HGFA-deficient mice died through day 12 while 75% of control mice survived injury.	Water	86-91	hepatocyte growth factor activator	Mus musculus	112-116
15075408-4	2004	Surprisingly, refolding of the nonnative cpn10 heptamer is a simple two-state kinetic process with a folding-rate constant in water (2.1 sec(-1); pH 7.0, 20 degrees C) that is in excellent agreement with the prediction based on the native-state topology of the cpn10 monomer.	Water	126-131	heat shock protein family E (Hsp10) member 1	Homo sapiens	41-46
22639633-7	2012	The isolation of mutants with a modified suberin composition facilitated physiological studies revealing that the strong reduction in suberin in cyp86a1 mutants results in increased root water and solute permeabilities.	Water	187-192	cytochrome P450, family 86, subfamily A, polypeptide 1	Arabidopsis thaliana	145-152
15075408-4	2004	Surprisingly, refolding of the nonnative cpn10 heptamer is a simple two-state kinetic process with a folding-rate constant in water (2.1 sec(-1); pH 7.0, 20 degrees C) that is in excellent agreement with the prediction based on the native-state topology of the cpn10 monomer.	Water	126-131	heat shock protein family E (Hsp10) member 1	Homo sapiens	261-266
15165989-5	2004	In contrast, after 1-8 h of treatment with H(2)O(2), the percent of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-stained cells was more than twofold higher in WT than OPN(-/-) cells.	Water	43-48	secreted phosphoprotein 1	Mus musculus	200-203
22149476-0	2012	Anisotropic growth of water-puckered pentamers on a mica terrace.	Water	22-27	MHC class I polypeptide-related sequence A	Homo sapiens	52-56
15265288-0	2004	Transcellular water transport and stability of expression in aquaporin 1-transfected LLC-PK1 cells in the development of a portable bioartificial renal tubule device.	Water	14-19	aquaporin-1	Sus scrofa	61-72
15265288-5	2004	The expression and localization of water AQP1 were examined by Western blotting, RT-PCR, and immunofluorescence.	Water	35-40	aquaporin 1	Rattus norvegicus	41-45
15265288-7	2004	In contrast to wild-type LLC-PK(1) cells, rat AQP1-transfected cells had high transcellular osmotic water permeability.	Water	100-105	aquaporin 1	Rattus norvegicus	46-50
15326087-4	2004	The Ang-(1-7) antagonist A-779 completely blocked the antidiuretic effect of AVE. As observed previously for Ang-(1-7), the antidiuretic effect of AVE after water load was blunted in Mas-knockout mice (0.37+/-0.10 mL/60 min [n=9] versus 0.27+/-0.03 mL/60 min [n=11] AVE-treated mice).	Water	157-162	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	4-12
22149476-1	2012	Ice nucleation at mica terrace edges in air forms mounds of water molecules that grow larger as the step-edge height increases from a few Angstroms to hundreds of nanometers.	Water	60-65	MHC class I polypeptide-related sequence A	Homo sapiens	18-22
22209488-4	2012	Either with a free or acetyl capped N-terminus, these agonist peptides display significant propensity in aprotic (DMSO) or lipidic (water-SDS) solvents for turn-like conformations, which are predicted to be receptor-binding conformations in the transmembrane or loops region of PAR2.	Water	132-137	F2R like trypsin receptor 1	Homo sapiens	278-282
15907052-8	2004	The effect of injections of 5-HT1A receptor agonist is more pronounced on water intake.	Water	74-79	5-hydroxytryptamine receptor 1A	Rattus norvegicus	28-34
15907052-9	2004	The effect of injections of 5HT3 receptor antagonist is also more pronounced on water intake.	Water	80-85	5-hydroxytryptamine receptor 3A	Rattus norvegicus	28-41
15099064-1	2004	The water-immiscible ionic liquid, [C4MIM][PF6], is a solvent medium that allows complete transfer of gold nanoparticles from an aqueous phase into an organic phase.	Water	4-9	sperm associated antigen 17	Homo sapiens	43-46
22123821-5	2012	Substitution of the putative catalytic base for water attack on the thioester (Glu(161)) by an incompetent analog (Gln(161)) gave a UGDH variant (E161Q) in which the hydrolysis step had become completely rate-limiting so that a thioester enzyme intermediate accumulated at steady state.	Water	48-53	UDP-glucose 6-dehydrogenase	Homo sapiens	132-136
15144663-6	2004	SB203580 inhibited the activation of p38 MAPK, reduced the pulmonary capillary leakage permeability (24.7 +/- 2.9 vs. 42.5 +/- 4.7, P &lt; 0.01), decreased lung water content, and prevented burn-mediated lung injury.	Water	161-166	mitogen activated protein kinase 14	Rattus norvegicus	37-40
15377788-2	2004	The structure of this eukaryotic, integral membrane protein suggests that the selectivity of AQP0 for water transport is based on the identity and location of signature amino acid residues that are hallmarks of the water-selective arm of the AQP family of proteins.	Water	102-107	major intrinsic protein of lens fiber	Bos taurus	93-97
15377788-2	2004	The structure of this eukaryotic, integral membrane protein suggests that the selectivity of AQP0 for water transport is based on the identity and location of signature amino acid residues that are hallmarks of the water-selective arm of the AQP family of proteins.	Water	215-220	major intrinsic protein of lens fiber	Bos taurus	93-97
15377788-6	2004	We observed no structural change to the channel or the molecule as a whole at pH 10, which could be interpreted as the postulated pH-gating mechanism of AQP0-mediated water transport at pH &gt;6.5.	Water	167-172	major intrinsic protein of lens fiber	Bos taurus	153-157
15360238-2	2004	We report a molecular dynamics study of the solvation of the UO2(2+) and Eu3+ cations and their chloro complexes in the [BMI][PF6][H2O] "humid" room-temperature ionic liquid (IL) composed of 1-butyl-3-methylimidazolium+ and PF6- ions and H2O in a 1:1:1 ratio.	Water	131-134	sperm associated antigen 17	Homo sapiens	126-129
15014350-1	2004	Combretastatin A4 phosphate (CA4P) is a water-soluble prodrug of combretastatin A4 (CA4).	Water	40-45	carbonic anhydrase 4	Homo sapiens	0-17
22051630-2	2012	At pH &lt; 4.0 where hydrolysis of [Ru(eta(6)-p-cym)(H(2)O)(3)](2+) is negligible with increasing chloride ion concentration two chlorido complexes, [Ru(eta(6)-p-cym)(H(2)O)(2)Cl](+) and [{Ru(eta(6)-p-cym)}(2)(mu(2)-Cl)(3)](+), are detectable.	Water	53-60	endothelin receptor type A	Homo sapiens	39-42
15014350-1	2004	Combretastatin A4 phosphate (CA4P) is a water-soluble prodrug of combretastatin A4 (CA4).	Water	40-45	carbonic anhydrase 4	Homo sapiens	29-32
22101039-0	2012	Enterococcus faecium of the vanA genotype in rural drinking water, effluent, and the aqueous environment.	Water	60-65	Vancomycin Teicoplanin A-type resistance protein VanA / D-alanine--D-alanine ligase	Enterococcus faecium	28-32
22024096-2	2012	Application of synthetic hydroxyapatite (HA) and natural phosphate rock (FAP) effectively reduced the heavy metal water solubility generally by about 84-99%.	Water	114-119	fibroblast activation protein alpha	Homo sapiens	73-76
15090960-14	2004	In healthy animals, the administration of endothelin-1 induced systemic and pulmonary hypertension, increased extravascular lung water index, and evoked bradycardia and a decrease in cardiac index.	Water	129-134	EDN1	Ovis aries	42-54
12920053-6	2004	PLUNC was poorly soluble in water (50 microg/ml) or in 50 mM NaCl but was more soluble in 75% ethanol (&gt; 380 microg/ml).	Water	28-33	BPI fold containing family A member 1	Homo sapiens	0-5
22024096-5	2012	HA and FAP could significantly reduce Cd, Cu, Pb, and Zn availability in terms of water solubility in contaminated soils while minimizing soil acidification and potential risk of eutrophication associated with the application of highly soluble phosphate sources.	Water	82-87	fibroblast activation protein alpha	Homo sapiens	7-10
22830346-5	2012	Low solubility of BAT in water, high toxicity and necessity of high drug dosing are major limitations of its use as a chemotherapeutic drug.	Water	25-30	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	18-21
14637340-4	2004	Aspen wood-water sorption coefficients, Kww, were linearly correlated to octanol-water partition coefficients and the molecular weight of the studied PAH compounds.	Water	11-16	phenylalanine hydroxylase	Homo sapiens	150-153
22830346-13	2012	A series of novel BAT analogs bearing sugar residues and thiocarbonyl aminoacids, which provided better solubility in water and high cytostatic activity have been designed.	Water	118-123	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	18-21
21695538-5	2012	Optimization modeling predicted maximum (192 mug/l) TMHs formation (highest risk) level in water during chlorination was very close to the experimental value (186.8 +- 1.72 mug/l) determined in laboratory experiments.	Water	91-96	LHFPL tetraspan subfamily member 5	Homo sapiens	52-56
15499173-0	2004	Proapoptotic effect of a dietary supplement: water soluble chitosan activates caspase-8 and modulating death receptor expression.	Water	45-50	caspase 8	Homo sapiens	78-117
22486663-4	2012	The biofilms were characterized by a sorption isotherm Type III with toluene; the water desorption isotherm was fitted to the BET model and the biofilm hydrophobicity was also determined.	Water	82-87	delta/notch like EGF repeat containing	Homo sapiens	126-129
14766955-4	2004	In nondiapausing pupae, the expression of two inducible Hsps (Hsp23 and Hsp70) is upregulated by desiccation, but the water loss threshold for Hsp expression changes at different rates of dehydration.	Water	118-123	Heat-shock-protein-70Ab	Drosophila melanogaster	72-77
21541689-3	2012	Therefore, the effects of the water-soluble randomly methylated-beta-cyclodextrin (RAMEB) complex of lutein were investigated on TRPV1 and TRPA1 activation.	Water	30-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	129-134
22108714-7	2012	The cumulative water intake was significantly reduced by apelin-13 (3mug/mouse) at 4h after injection in freely feeding and fasted mice.	Water	15-20	apelin	Mus musculus	57-63
21950760-4	2012	Higher protein levels of ZmPIP1;2, ZmPIP2;1/2;2, ZmPIP2;5 and ZmPIP2;6 during the day coincided with a higher water permeability of root cortex cells during the day compared with night period.	Water	110-115	aquaporin PIP1-2	Zea mays	25-33
21950760-7	2012	These data support a role of specific PIP isoforms, in particular ZmPIP1;2 and ZmPIP2;5, in regulating root water uptake and cortex cell hydraulic conductivity in maize.	Water	108-113	aquaporin PIP1-2	Zea mays	66-74
23284675-2	2012	Selective ablation of Ctip2 in epidermis leads to increased transepidermal water loss (TEWL), impaired epidermal proliferation, terminal differentiation, as well as altered lipid composition during development.	Water	75-80	B cell leukemia/lymphoma 11B	Mus musculus	22-27
23029053-6	2012	We conclude the merging of the EVI and delta(18)O in precipitation can greatly extend the spatial and temporal data availability and thus enhance the applicability for both the EVI and water isoscape.	Water	185-190	Wnt ligand secretion mediator	Homo sapiens	31-34
23029347-0	2012	Aquaporin-1 translocation and degradation mediates the water transportation mechanism of acetazolamide.	Water	55-60	aquaporin 1	Mus musculus	0-11
23029502-1	2012	Previous studies reported that a subpopulation of mouse and rat trigeminal neurons express water channel aquaporin-1 (AQP1).	Water	91-96	aquaporin 1	Rattus norvegicus	118-122
22761926-2	2012	In the brain, a functional secretin (SCT) and secretin receptor (SCTR) axis has recently been shown to mediate central actions of angiotensin II (ANGII), including initiation of water intake and stimulation of vasopressin (VP) expression and release.	Water	178-183	secretin	Mus musculus	27-35
22761926-2	2012	In the brain, a functional secretin (SCT) and secretin receptor (SCTR) axis has recently been shown to mediate central actions of angiotensin II (ANGII), including initiation of water intake and stimulation of vasopressin (VP) expression and release.	Water	178-183	secretin	Mus musculus	37-40
22907447-5	2012	The quantitative determination of dyes spiked in real water samples was carried out successfully by PLS-1 with satisfactory recoveries for dyes (90-106%).	Water	54-59	plastin 1	Homo sapiens	100-105
22006033-0	2011	Water-catalyzed gas-phase hydrogen abstraction reactions of CH3O2 and HO2 with HO2: a computational investigation.	Water	0-5	heme oxygenase 2	Homo sapiens	70-73
22006033-0	2011	Water-catalyzed gas-phase hydrogen abstraction reactions of CH3O2 and HO2 with HO2: a computational investigation.	Water	0-5	heme oxygenase 2	Homo sapiens	79-82
21964507-10	2011	These data indicate that: (1) an increase in H(2)O(2) is necessary for glucocorticoid-induced apoptosis in lymphoid cells, (2) increased H(2)O(2) removal causes glucocorticoid resistance, and (3) MEK inhibition can sensitize oxidative stress-resistant cells to glucocorticoids.	Water	45-50	midkine	Mus musculus	196-199
15329587-1	2004	BACKGROUND: GPI 15715 is a new water-soluble prodrug that is hydrolyzed to release propofol.	Water	31-36	glucose-6-phosphate isomerase	Homo sapiens	12-15
22346781-7	2011	METHODS: EAU was induced by immunization with human interphotoreceptor retinoid-binding protein (IRBP) peptide(1-20).	Water	9-12	retinol binding protein 3	Homo sapiens	52-95
22346781-7	2011	METHODS: EAU was induced by immunization with human interphotoreceptor retinoid-binding protein (IRBP) peptide(1-20).	Water	9-12	retinol binding protein 3	Homo sapiens	97-101
21929693-8	2011	Treatment of ADX rats with CORT in the drinking water normalised this enhanced pERK1/2 response to stress.	Water	48-53	cortistatin	Rattus norvegicus	27-31
22340790-1	2011	OBJECTIVE: To observe expression pattern of aquaporin 4 (AQP4) in brain tissue of severely scalded rabbit during early stage of brain edema and its relationship with signal changes in magnetic resonance imaging (MRI), and to explore the feature of water transmembrane transportation in brain edema at early stage after severe scald.	Water	248-253	aquaporin-4	Oryctolagus cuniculus	57-61
21981450-8	2011	The agreement between macroscopic observables and molecular simulations confirms the role of water-shielded hydrogen bonds as kinetic traps and illustrates how our finding could be used as an aid in structure-based drug discovery.	Water	93-98	activation induced cytidine deaminase	Homo sapiens	192-195
21978216-10	2011	The variations in the fibrillar networks provide a comprehensive picture and detailed insights into why seemingly very similar NCl-n behave very differently during their self-assembly processes in water and organic liquids.	Water	197-202	nucleolin	Homo sapiens	127-130
21615722-4	2011	We hypothesized that a decrease in nNOS-derived H(2)O(2) contributes to the impaired vasodilatation in apolipoprotein E-deficient mice (ApoE(-/-)).	Water	48-53	nitric oxide synthase 1, neuronal	Mus musculus	35-39
14764228-6	2004	Plasma levels of endotoxin and TNF in group A and B were increased significantly after exposure of peritoneal cavity to sea water (compared with baseline values, all P&lt;0.05).	Water	124-129	tumor necrosis factor-like	Rattus norvegicus	31-34
21615722-9	2011	Inhibition of nNOS with L-Arg(NO2) -L-Dbu, knockdown of nNOS and catalase, which decomposes H(2)O(2) into oxygen and water, decreased ACh-induced relaxation by half, produced a small diminution of NO production and abolished H(2)O(2) in wild-type animals, but had no effect in ApoE(-/-) mice.	Water	117-122	nitric oxide synthase 1, neuronal	Mus musculus	14-18
21615722-9	2011	Inhibition of nNOS with L-Arg(NO2) -L-Dbu, knockdown of nNOS and catalase, which decomposes H(2)O(2) into oxygen and water, decreased ACh-induced relaxation by half, produced a small diminution of NO production and abolished H(2)O(2) in wild-type animals, but had no effect in ApoE(-/-) mice.	Water	117-122	nitric oxide synthase 1, neuronal	Mus musculus	56-60
14698296-5	2004	The IBP structure shows a direct and a water-mediated electrostatic interaction between Glu and Arg side-chains from adjacent strands, but no intra-strand interactions.	Water	39-44	trafficking protein particle complex subunit 9	Homo sapiens	4-7
22016396-8	2011	HA and TGF-beta levels were lower in homozygous UTI-KO mice that were continuously administered UTI versus those given distilled water.	Water	129-134	transforming growth factor, beta 1	Mus musculus	7-15
14704123-0	2004	Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water channel.	Water	94-99	aquaporin 1	Mus musculus	89-93
14704123-1	2004	AIM: To study the effect of topiramate on tumor metastasis and its relation with aquaporin 1 (AQP1) water channel.	Water	100-105	aquaporin 1	Mus musculus	81-92
14704123-1	2004	AIM: To study the effect of topiramate on tumor metastasis and its relation with aquaporin 1 (AQP1) water channel.	Water	100-105	aquaporin 1	Mus musculus	94-98
22413223-1	2011	We have synthesized water soluble zinc selenium (ZnSe) nanocrystals by using mercaotoacetic acid (TGA) as the stabilizer.	Water	20-25	T-box transcription factor 1	Homo sapiens	98-101
14704123-4	2004	Western blotting and immunohistochemical analysis were used to study the influence of topiramate on AQP1 water channel expression in lungs or tumor tissues of mice bearing Lewis lung carcinoma.	Water	105-110	aquaporin 1	Mus musculus	100-104
14704123-9	2004	CONCLUSION: Suppression of AQP1 water channel expression may be an important pathway for the inhibitory effect of topiramate on tumor metastasis.	Water	32-37	aquaporin 1	Mus musculus	27-31
21981964-9	2011	MC3T3-E1 cells showed mineralization at day 28. mRNA expression levels of both osteopontin and runt-related transcription factor 2 in MC3T3-E1 cells were higher in the iQPR-H2O group compared with the control group.	Water	173-176	secreted phosphoprotein 1	Mus musculus	79-90
14964364-7	2004	Relationships between water-soluble P and DPS indicate that the respective change points are: DPS(Ox) = 20%, DPS(M1) = 20%, and DPS(M3) = 16%.	Water	22-27	decaprenyl diphosphate synthase subunit 1	Homo sapiens	42-45
21850309-1	2011	Two Schiff bases: 2-(1-(methylimino)methyl)-phenol (SMA) and its chlorosubstituted derivative 2-(1-(methylimino)methyl)-6-chlorophenol (SMAC), and SMA complexes with water were studied by infrared matrix isolation spectroscopy and DFT/B3LYP/6-311G++(2d,2p) quantum chemical calculations.	Water	166-171	survival of motor neuron 1, telomeric	Homo sapiens	52-55
15307610-6	2004	Differences between the magnitude of overall migration into distilled water (0.5-1.1 mg/dm2) and 3% acetic acid are probably due to the presence of easy washable substances into the sour medium.	Water	70-75	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	88-91
15344779-10	2004	After treatment of RO, excellent water quality of permeate were under 5 mg/l, 2.5 mg/l and 150 micros/cm for COD, TOC and conductivity respectively.	Water	33-38	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	109-112
21850309-6	2011	In the argon matrices doped with SMA and H(2)O the SMA-water complexes were identified and characterized spectroscopically.	Water	41-46	survival of motor neuron 1, telomeric	Homo sapiens	51-54
21850309-6	2011	In the argon matrices doped with SMA and H(2)O the SMA-water complexes were identified and characterized spectroscopically.	Water	55-60	survival of motor neuron 1, telomeric	Homo sapiens	33-36
21850309-6	2011	In the argon matrices doped with SMA and H(2)O the SMA-water complexes were identified and characterized spectroscopically.	Water	55-60	survival of motor neuron 1, telomeric	Homo sapiens	51-54
15500082-1	2003	Treatment of female SAMP-1 mice with Neuronol (drug containing succinic acid) given with drinking water starting from the age of 2 months during the whole life prolonged the lifespan and markedly reduced mortality of animals aged 1.5-2 years.	Water	98-103	transmembrane protein 201	Mus musculus	20-26
21850309-7	2011	Interaction of SMA with one or two water molecules does not affect the photochemistry of SMA.	Water	35-40	survival of motor neuron 1, telomeric	Homo sapiens	15-18
21718684-6	2011	The proton-pumping pathway of bovine heart cytochrome c oxidase includes a hydrogen-bond network and a water channel located in tandem between the positive and negative side of the mitochondrial membrane.	Water	103-108	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	43-63
14607234-4	2003	The protic solvent effects demonstrate that mechanical couplings are different in the 1500-1700 cm(-1) range for the nuC=O and nu8b (valence of the ring) modes in NHP and NDP (or (NHP, H2O) and (NDP, D2O)).	Water	185-188	nucleobindin 1	Homo sapiens	117-120
14607234-4	2003	The protic solvent effects demonstrate that mechanical couplings are different in the 1500-1700 cm(-1) range for the nuC=O and nu8b (valence of the ring) modes in NHP and NDP (or (NHP, H2O) and (NDP, D2O)).	Water	185-188	norrin cystine knot growth factor NDP	Homo sapiens	171-174
21784787-2	2011	More recent studies show that ghrelin reduces water intake in rats and some non-mammalian species.	Water	46-51	ghrelin and obestatin prepropeptide	Rattus norvegicus	30-37
14597669-4	2003	Gelsolin is the major water-soluble protein in the zebrafish (approximately 50%) and Anableps dorsal (approximately 38%) and ventral (approximately 21%) corneal epithelia, suggesting that gelsolin was recruited for high corneal expression before these two species diverged at least 100 million years ago and that abundant corneal gelsolin is not limited to aquatic vision.	Water	22-27	gelsolin a	Danio rerio	0-8
21784787-5	2011	We found that ghrelin attenuated saline intake stimulated by angiotensin II, by water deprivation followed by partial rehydration and by dietary sodium deficiency.	Water	80-85	ghrelin and obestatin prepropeptide	Rattus norvegicus	14-21
21784787-7	2011	The finding that ghrelin reduced hypertonic saline intake in some, but not all, natriorexigenic conditions mirrors the previously published findings that in one-bottle tests of drinking, ghrelin reduces water intake in only some conditions.	Water	203-208	ghrelin and obestatin prepropeptide	Rattus norvegicus	17-24
21784787-7	2011	The finding that ghrelin reduced hypertonic saline intake in some, but not all, natriorexigenic conditions mirrors the previously published findings that in one-bottle tests of drinking, ghrelin reduces water intake in only some conditions.	Water	203-208	ghrelin and obestatin prepropeptide	Rattus norvegicus	187-194
21962197-5	2011	Merc sol was added to mice"s drinking water for 7 days (in vivo treatment) and animals were euthanised and cells were collected.	Water	38-43	hnRNP-associated with lethal yellow	Mus musculus	0-4
14597669-4	2003	Gelsolin is the major water-soluble protein in the zebrafish (approximately 50%) and Anableps dorsal (approximately 38%) and ventral (approximately 21%) corneal epithelia, suggesting that gelsolin was recruited for high corneal expression before these two species diverged at least 100 million years ago and that abundant corneal gelsolin is not limited to aquatic vision.	Water	22-27	gelsolin a	Danio rerio	188-196
21962197-7	2011	RESULTS: Macrophages showed activated morphology, both when Merc sol was added directly to the cell culture and to drinking water.	Water	124-129	hnRNP-associated with lethal yellow	Mus musculus	60-64
14652680-0	2003	Effects of water-soluble cigarette smoke extracts upon the release of beta-hexosaminidase from RBL-2H3 basophilic leukaemia cells in response to substance P, compound 48/80, concanavalin A and antigen stimulation.	Water	11-16	O-GlcNAcase	Rattus norvegicus	70-89
15517891-5	2004	Two cohorts of Her2/NeuN female mice of different age (eleven-week-old and twenty-four-week-old) chronically treated with Sasa Health in drinking water showed both a delay in the development of tumors and reduced tumor multiplicity.	Water	146-151	RNA binding protein, fox-1 homolog (C. elegans) 3	Mus musculus	20-24
21484797-8	2011	Unlike curcumin itself, the [DLys(6)]-LHRH-curcumin conjugate is water soluble which allows its intravenous administration.	Water	65-70	gonadotropin releasing hormone 1	Homo sapiens	38-42
15276721-5	2004	The measured PAH concentrations in sediments and soils (224-4222 ng/g), runoff water (8.3 microg/l) and air particles (2.3 microg/m(3)) are discussed in relation to concentrations and patterns found in the surface water bodies.	Water	214-219	phenylalanine hydroxylase	Homo sapiens	13-16
15276721-7	2004	The atmospheric PAH deposition to water bodies in the city area of Hangzhou was estimated to be 530 tons/a, while the contribution of surface runoff water was estimated to be 30.7 tons/a.	Water	34-39	phenylalanine hydroxylase	Homo sapiens	16-19
14657262-7	2003	Furthermore, the HDC-KO mice showed improved water-maze performance during both hidden and cued platform tasks, but deficient object discrimination based on temporal relationships.	Water	45-50	histidine decarboxylase	Mus musculus	17-20
21752391-1	2011	In a preceding paper it was found that, during coating with solutions of a stearin salt in water, whatever the concentration used, a considerable part of the PCC surface remains free, indicating the development of an incomplete monolayer.	Water	91-96	crystallin gamma D	Homo sapiens	158-161
14527451-6	2003	It was found that the main reason HD could not be encapsulated completely by PSt when conversion was lower was that the interfacial tension of the HD phase with water and the PSt phase with water got closer.	Water	190-195	sulfotransferase family 1A member 1	Homo sapiens	175-178
21898801-5	2011	Control of the MIP-SPE process is seen as important in helping to facilitate the selective extraction of mBP from water samples.	Water	114-119	myelin basic protein	Mus musculus	105-108
14505797-1	2003	9-aminocamptothecin glucuronide (9ACG) is a new water-soluble prodrug of 9-aminocamptothecin (9AC) that is a substrate for beta-glucuronidase and displays potent antitumor activity against human tumor xenografts.	Water	48-53	glucuronidase beta	Homo sapiens	123-141
21898801-9	2011	The developed MIP-SPE method was demonstrated to be applicable for the analysis of mBP in the bottled water.	Water	102-107	myelin basic protein	Mus musculus	83-86
21775423-5	2011	In ewes treated with exogenous gonadotrophins following a BMP15-BSA peptide immunisation in a water-based adjuvant to partially neutralise BMP15 bioactivity, the ovulation rate response was similar to the control superovulation treatment groups.	Water	94-99	bone morphogenetic protein 15	Ovis aries	139-144
12907408-2	2003	Oxalates were extracted in water by refluxing for 2 h. The method is based on the oxidation of oxalate by the oxidase and the determination of the resulting hydrogen peroxide, which in presence of peroxidase, 3-methyl-2 benzotiazinolone and 3-dimethylamino benzoic, gives an indamine compound with an absorption maximum at 590 nm.	Water	27-32	peroxidase 3	Cicer arietinum	197-207
12907315-8	2003	Spinal infusion of NGF did not affect the expression of tactile allodynia or thermal (hot) hyperalgesia in neuropathic rats, although it significantly increased cold water responses frequency at day 14.	Water	166-171	nerve growth factor	Rattus norvegicus	19-22
21775423-6	2011	Characterisation of follicular function revealed that the water-based BMP15-immunised animals had fewer non-atretic follicles 2.5-3.5 or &gt; 4.5  mm in diameter compared with controls.	Water	58-63	bone morphogenetic protein 15	Ovis aries	70-75
21792440-0	2011	A kinetic and thermodynamic study of the unexpected comproportionation reaction between cis-[Os(VIII)O4(OH)2](2-) and trans-[Os(VI)O2(OH)4](2-) to form a postulated [Os(VII)O3(OH)3](2-) complex anion.	Water	103-108	cytochrome c oxidase subunit 8A	Homo sapiens	96-100
12838423-1	2003	The expression and localization of aquaporins (AQP1-AQP5), members of the water channel family, in the developing rat submandibular gland were analysed using RT-PCR, Northern blotting and immunohistochemistry to explore their relation to the development of this salivary gland.	Water	74-79	aquaporin 1	Rattus norvegicus	47-51
21511033-11	2011	Our data suggest that the increased water permeability through AQP1 does not compensate for loss of AQP0 expression in TgAQP1(+/+)/AQP0(-/-) mice.	Water	36-41	aquaporin 1	Mus musculus	63-67
14766088-6	2003	Treatment with N-acetyl-L-cysteine and catalase could inhibit lens opacification, apoptosis and caspase-3 activation induced by H(2)O(2).	Water	128-133	caspase 3	Rattus norvegicus	96-105
21529340-0	2011	The water effect on the kinetic of the bovine liver catalase.	Water	4-9	catalase	Bos taurus	52-60
12749765-7	2003	We found that by treating the transfected cells with the small, water-soluble, thiol-reactive anionic reagent, sodium (2-sulphonatoethyl) methanethiosulphonate, methotrexate transport by several of the cysteine-substituted hRFC mutants was significantly inhibited, including Q40C, G44C, E45C and I48C.	Water	64-69	solute carrier family 19 member 1	Homo sapiens	223-227
12888658-8	2003	In contrast, the mRNA level of DNA damage-inducible transcript 1, gadd45, was significantly increased by 2.28-fold in HT-29 cells treated with selenite but not fecal water.	Water	166-171	growth arrest and DNA damage inducible alpha	Homo sapiens	31-64
12888658-8	2003	In contrast, the mRNA level of DNA damage-inducible transcript 1, gadd45, was significantly increased by 2.28-fold in HT-29 cells treated with selenite but not fecal water.	Water	166-171	growth arrest and DNA damage inducible alpha	Homo sapiens	66-72
21728337-7	2011	For the more solvent exposed binding sites of trypsin and galectin-3, no accurate continuum estimates could be obtained, even if the binding site was allowed or prohibited to be filled by continuum water.	Water	198-203	galectin 3	Homo sapiens	58-68
21849545-0	2011	Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study.	Water	31-36	solute carrier family 12, member 2	Mus musculus	133-138
12902198-1	2003	We have previously reported that the gpt transgene in G12 Chinese hamster cells could be silenced by water-insoluble nickel compounds nickel sulfide (NiS) or nickel subsulfide (Ni(3)S(2)) and showed that the transgene was silenced by de novo DNA methylation and chromatin condensation.	Water	101-106	glutamic--pyruvic transaminase	Homo sapiens	37-40
21543742-2	2011	Carbonic anhydrases (CA) provide substrate for AE1 by catalyzing the reaction, H(2)O + CO(2)   HCO(3)(-) + H(+).	Water	79-84	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	47-50
15011044-3	2003	For shear-thinning fluids with a zero yield stress (mostly xanthan-water solutions), hri decreases down to 28-30% of the radius for the most concentrated solutions.	Water	67-72	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	85-88
21487246-5	2011	Hydrogen peroxide (H 2O 2) and loss of superoxide dismutase 1 (SOD1)-mediated oxidative stress promotes cytosolic HMGB1 expression and extracellular release.	Water	19-23	high mobility group box 1	Homo sapiens	114-119
12673771-1	2003	A biohydrogen production system coupling the polysaccharide such as sucrose and maltose degradation with invertase and glucose dehydrognase (GDH) and hydrogen production with colloidal platinum as hydrogen-evolved catalyst using the visible light-induced photosensitization of water-soluble zinc porphyrin, zinc tetraphenylporphyrin tetrasulfonate (ZnTPPS) has been investigated.	Water	277-282	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	141-144
12775386-0	2003	Water, sanitation and hygiene: a situation analysis paper for Lao PDR.	Water	0-5	interleukin 4 induced 1	Homo sapiens	62-65
22007516-7	2011	Water extract of Schisandra chinensis (100-500 microg x mL(-1)) also exhibited inhibition on the activity of CYP450 isozymes in vitro, whereas multiple administrations (1.5 g x kg(-1), qd x 7d) had significant induction of CYP2E1 and inhibition on CYP2D2, no effect on CYP2C6, CYP3A1/2, CYP1A2 or CYP2C11.	Water	0-5	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	277-283
16256595-3	2003	The higher water vapor adsorption of the chemically activated products is attributed to the higher specific surface area (S(BET)) and greater hydrophilic activity (arising from the surface oxygen-containing functional groups) than in the physically activated products.	Water	11-16	delta/notch like EGF repeat containing	Homo sapiens	124-127
21708133-6	2011	The amount of CFTR chloride channel or AQP1 water channel expressed in pancreatic ducts was examined by immunoblotting with antibodies against CFTR or AQP1, respectively.	Water	44-49	aquaporin-1	Cavia porcellus	39-43
12746550-0	2003	Stabilization of quaternary structure of water-soluble quinoprotein glucose dehydrogenase.	Water	41-46	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	68-89
12746550-1	2003	Water-soluble quinoprotein glucose dehydrogenase (PQQGDH-B) is a dimeric enzyme whose application for glucose sensing is the focus of much attention.	Water	0-5	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	27-48
21558796-2	2011	The presence of large, water-filled pores with uncontrolled ion permeability, such as those formed by Sec61 complexes in the ER membrane, would interfere with the regulated release of calcium from the ER lumen into the cytosol, an essential mechanism of intracellular signaling.	Water	23-28	translocon subunit SEC61	Saccharomyces cerevisiae S288C	102-107
12835933-3	2003	GLP gene expression, oxalate oxidase protein activity, the H(2)O(2) content of stressed seedlings, but not catalase activity, were induced by stress germination conditions (e.g. excess water, NaCl, mannitol, or oxalate) in a good emerging hybrid and were not induced in a poor emerging variety.	Water	185-190	germin-like protein	Beta vulgaris subsp. vulgaris	0-3
21540348-0	2011	A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated.	Water	39-44	ATP binding cassette subfamily C member 8	Homo sapiens	87-91
21562844-4	2011	We screened ethyl methanesulfonate-treated Arabidopsis thaliana plants with a focus on stomatal aperture-dependent water loss in detached leaves and isolated a rapid transpiration in detached leaves 1 (rtl1) mutant that we identified as a novel missense mutant of CHLH.	Water	115-120	RNAse THREE-like protein 1	Arabidopsis thaliana	202-206
12768109-3	2003	HSD"s primary mechanism of action is rapid osmotic mobilization of cellular water into the blood volume.	Water	76-81	carbohydrate sulfotransferase 3	Homo sapiens	0-3
21497995-0	2011	Laboratory studies using naturally occurring "green rust" to aid metal mine water remediation.	Water	76-81	activation induced cytidine deaminase	Homo sapiens	61-64
12639918-5	2003	Scatchard analysis of radioligand binding curves showed that E(2) or captopril (Cap; 0.5 g/liter water) significantly reduced adrenal AT(1)R binding (maximum binding capacity) by 22% and 19%, respectively, compared with OVX (276 +/- 2.09 fmol/mg protein).	Water	97-102	angiotensin II receptor, type 1a	Rattus norvegicus	134-140
26596428-4	2011	We find a strongly hydrogen bound water layer close to the KDP surface, comparing closely to a highly ordered water layer observed experimentally.	Water	34-39	WNK lysine deficient protein kinase 1	Homo sapiens	59-62
12679445-11	2003	In addition, PTH may be selectively more effective than PTHrP in stimulating 1,25-(OH)(2)D production, in contrast to its phosphaturic, calcemic effects and its effects to stimulate nephrogenous cAMP excretion and renal tubular calcium reabsorption.	Water	83-88	parathyroid hormone like hormone	Homo sapiens	56-61
26596428-4	2011	We find a strongly hydrogen bound water layer close to the KDP surface, comparing closely to a highly ordered water layer observed experimentally.	Water	110-115	WNK lysine deficient protein kinase 1	Homo sapiens	59-62
21663598-5	2011	Thus it is tempting to assume that LI-cadherin regulates the water transport through the epithelium in a passive fashion by changing its binding activity in dependence on the extracellular Ca2+.	Water	61-66	cadherin 17	Homo sapiens	35-46
12742031-4	2003	The BET(H2O) surface area of PCB was 514+/-36 m2/g.	Water	8-11	delta/notch like EGF repeat containing	Homo sapiens	4-7
12742031-6	2003	A surface area value of 504+/-45 m2/g calculated using the mean crystallite dimensions was in good agreement with the BET(H2O) surface area.	Water	122-125	delta/notch like EGF repeat containing	Homo sapiens	118-121
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	42-47	MHC class I polypeptide-related sequence A	Homo sapiens	48-52
12631466-5	2003	Water deprivation for a shorter time period (24 h) or rehydration (24 h access to water following 48 h of water deprivation) also elevated kidney cul-5 mRNA levels.	Water	82-87	cullin 5	Rattus norvegicus	146-151
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	42-47	MHC class I polypeptide-related sequence A	Homo sapiens	297-301
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	42-47	MHC class I polypeptide-related sequence A	Homo sapiens	297-301
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	42-47	MHC class I polypeptide-related sequence A	Homo sapiens	48-52
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	42-47	MHC class I polypeptide-related sequence A	Homo sapiens	297-301
26295415-3	2011	We found that ordered water structures at water/mica interfaces drastically diminished at molarities of sulfuric acid equal to 0.5 M and totally disappeared when the molarities reached 5 M. The decrease in ordered water structures at the interface was caused by a combined effect of the decreased mica surface potential at low pH, the adsorption of sulfates on mica, and the lack of free water molecules in high concentrations of acidic solution.	Water	42-47	MHC class I polypeptide-related sequence A	Homo sapiens	297-301
21534603-6	2011	We observed in situ and in real time the misfolding of hIAPP from random coils to alpha-helices and then beta-sheets upon interaction with a lipid-water interface.	Water	147-152	islet amyloid polypeptide	Homo sapiens	55-60
12593862-2	2003	In this study, the correlation between IRBP-specific Th1 cells in PBLs and the histological grading in the eyes was evaluated kinetically during EAU induction.	Water	145-148	retinol binding protein 3	Homo sapiens	39-43
21420135-2	2011	Our results indicate that water stress resulted in decreased shikimate pathway (DAHP synthase, shikimate dehydrogenase, phenylalanine ammonium lyase, cinnamate 4-hydroxylase, 4-coumarate CoA ligase) and phenolic compounds (caffeoylquinic acid derivatives, quercetin and kaempferol) in the cultivars more sensitive to water stress.	Water	26-31	probable pectate lyase P18	Solanum lycopersicum	143-148
12590600-1	2003	Arginine vasopressin (AVP) is a nonapeptide long known as an endocrine and paracrine regulator of important systemic functions, namely, vasoconstriction, gluconeogenesis, corticosteroidogenesis, and excretion of water and urea.	Water	212-217	arginine vasopressin	Mus musculus	22-25
12590610-7	2003	The urea m-value of the lacI HTH (-d deltaG(o)(obs),/dC(3) = 449 +/- 11 cal mol(-)(1) M(-)(1) at 25 degrees C) is independent of C(3) up to at least 6 M. Use of the LBDM to fit the C(3)-dependence of deltaG(o)(obs) yields the local-bulk partition coefficient for accumulation of urea at the protein surface exposed upon denaturation: K(P) = 1.103 +/- 0.002 at 25 degrees C. This partition coefficient is the same within uncertainty as those previously determined by LBDM analysis of osmometric data for solutions of urea and native (folded) bovine serum albumin, as well as LBDM analysis of the proportionality of m-values to changes in water accessible surface area upon protein unfolding.	Water	637-642	tissue factor pathway inhibitor	Homo sapiens	24-28
15210285-1	2004	Water quality assessment in the region of Fez based on the physicochemical and ecotoxicological investigations is presented.	Water	0-5	FEZ family zinc finger 1	Homo sapiens	42-45
15210285-7	2004	Well water in the region of Fez has moderately poor water quality with nitrate and metal enrichments.	Water	5-10	FEZ family zinc finger 1	Homo sapiens	28-31
21502813-1	2011	Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins that allow the movement of water and other small solutes, especially glycerol, through cell membranes.	Water	110-115	aquaporin 7	Homo sapiens	25-29
15210285-7	2004	Well water in the region of Fez has moderately poor water quality with nitrate and metal enrichments.	Water	52-57	FEZ family zinc finger 1	Homo sapiens	28-31
12468529-0	2003	Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs.	Water	28-33	aquaporin 1	Rattus norvegicus	23-27
12468529-3	2003	To address this issue, we designed, synthesized, and utilized small interfering RNAs (siRNAs) selective for AQP1 and investigated their effectiveness in altering AQP1-mediated water transport in intrahepatic bile duct units (IBDUs) isolated from rat liver.	Water	176-181	aquaporin 1	Rattus norvegicus	162-166
21446714-7	2011	Such water rearrangements contribute to the recognition of DNA by indolicidin, an antimicrobial 13-mer peptide from bovine neutrophils which, despite little intrinsic structure, preferentially binds to the B(I) conformer in a water-mediated induced fit.	Water	5-10	cathelicidin-4	Bos taurus	66-77
12468529-6	2003	Suppression of AQP1 expression in cholangiocytes resulted in a decrease in water transport by IBDUs in response to both an inward osmotic gradient (200 mosm) or a secretory agonist (forskolin), the osmotic water permeability coefficient (P(f)) decreasing up to 58.8% and net water secretion (J(v)) decreasing up to 87%.	Water	75-80	aquaporin 1	Rattus norvegicus	15-19
12468529-6	2003	Suppression of AQP1 expression in cholangiocytes resulted in a decrease in water transport by IBDUs in response to both an inward osmotic gradient (200 mosm) or a secretory agonist (forskolin), the osmotic water permeability coefficient (P(f)) decreasing up to 58.8% and net water secretion (J(v)) decreasing up to 87%.	Water	206-211	aquaporin 1	Rattus norvegicus	15-19
12468529-6	2003	Suppression of AQP1 expression in cholangiocytes resulted in a decrease in water transport by IBDUs in response to both an inward osmotic gradient (200 mosm) or a secretory agonist (forskolin), the osmotic water permeability coefficient (P(f)) decreasing up to 58.8% and net water secretion (J(v)) decreasing up to 87%.	Water	206-211	aquaporin 1	Rattus norvegicus	15-19
12468529-7	2003	A strong correlation between AQP1 protein expression and water transport in IBDUs transfected with AQP1-siRNAs was consistent with the decrease in water transport by IBDUs resulting from AQP1 gene silencing by AQP1-siRNAs.	Water	57-62	aquaporin 1	Rattus norvegicus	29-33
12468529-7	2003	A strong correlation between AQP1 protein expression and water transport in IBDUs transfected with AQP1-siRNAs was consistent with the decrease in water transport by IBDUs resulting from AQP1 gene silencing by AQP1-siRNAs.	Water	57-62	aquaporin 1	Rattus norvegicus	99-103
12468529-7	2003	A strong correlation between AQP1 protein expression and water transport in IBDUs transfected with AQP1-siRNAs was consistent with the decrease in water transport by IBDUs resulting from AQP1 gene silencing by AQP1-siRNAs.	Water	57-62	aquaporin 1	Rattus norvegicus	99-103
12468529-7	2003	A strong correlation between AQP1 protein expression and water transport in IBDUs transfected with AQP1-siRNAs was consistent with the decrease in water transport by IBDUs resulting from AQP1 gene silencing by AQP1-siRNAs.	Water	57-62	aquaporin 1	Rattus norvegicus	99-103
12468529-7	2003	A strong correlation between AQP1 protein expression and water transport in IBDUs transfected with AQP1-siRNAs was consistent with the decrease in water transport by IBDUs resulting from AQP1 gene silencing by AQP1-siRNAs.	Water	147-152	aquaporin 1	Rattus norvegicus	29-33
12468529-7	2003	A strong correlation between AQP1 protein expression and water transport in IBDUs transfected with AQP1-siRNAs was consistent with the decrease in water transport by IBDUs resulting from AQP1 gene silencing by AQP1-siRNAs.	Water	147-152	aquaporin 1	Rattus norvegicus	99-103
15742554-2	2004	An insulin nasal gel was prepared by dispersing carbopol in distilled water, followed by the addition of insulin solution, then neutralization and viscosity adjustment.	Water	70-75	insulin	Oryctolagus cuniculus	3-10
15623031-0	2004	[Inactivation of T4 phage in water environment using proteinase].	Water	29-34	endogenous retrovirus group K member 7	Homo sapiens	53-64
15623031-3	2004	In the optimum conditions and 67.5 u/mL concentration, the inactivation rate of proteinase K to T4 phage in sterilized water and in sewage achieved 99.4% and 49.4% respectively in an hour, and achieved &gt;99.9% and 81.1% in three hours.	Water	119-124	endogenous retrovirus group K member 7	Homo sapiens	80-90
15623031-4	2004	The inactivation rate of the industrial proteinase 1398 to T4 phage in sterilized water achieved 74.4% in an hour.	Water	82-87	endogenous retrovirus group K member 7	Homo sapiens	40-50
15323531-6	2004	The adhesion of proteins with uncharged SAMs showed a general "step" dependence on the wettability of the surface as determined by the water contact angle under cyclooctane (thetaco).	Water	135-140	methionine adenosyltransferase 1A	Homo sapiens	40-44
21446714-7	2011	Such water rearrangements contribute to the recognition of DNA by indolicidin, an antimicrobial 13-mer peptide from bovine neutrophils which, despite little intrinsic structure, preferentially binds to the B(I) conformer in a water-mediated induced fit.	Water	226-231	cathelicidin-4	Bos taurus	66-77
12468529-7	2003	A strong correlation between AQP1 protein expression and water transport in IBDUs transfected with AQP1-siRNAs was consistent with the decrease in water transport by IBDUs resulting from AQP1 gene silencing by AQP1-siRNAs.	Water	147-152	aquaporin 1	Rattus norvegicus	99-103
21401076-5	2011	The layer of H(UPD) embedded in the Pt surface lattice minimizes the surface dipole-water dipole and surface charge-water dipole interactions, thus reduces the wetting ability of Pt.	Water	84-89	uroporphyrinogen decarboxylase	Homo sapiens	15-18
12468529-7	2003	A strong correlation between AQP1 protein expression and water transport in IBDUs transfected with AQP1-siRNAs was consistent with the decrease in water transport by IBDUs resulting from AQP1 gene silencing by AQP1-siRNAs.	Water	147-152	aquaporin 1	Rattus norvegicus	99-103
12468529-8	2003	This study is the first to demonstrate the feasibility of utilizing siRNAs to specifically reduce the expression of AQPs in epithelial cells and provides direct evidence of the contribution of AQP1 to water transport by biliary epithelia.	Water	201-206	aquaporin 1	Rattus norvegicus	193-197
15310196-5	2004	The product is an intermediate nitrene (PhN) or a protonated nitrene (PhNH(+)) which is captured by water to give PhNHOH or aniline to give PhNHNHPh.	Water	100-105	carbamoyl-phosphate synthase 1	Homo sapiens	40-43
21401076-5	2011	The layer of H(UPD) embedded in the Pt surface lattice minimizes the surface dipole-water dipole and surface charge-water dipole interactions, thus reduces the wetting ability of Pt.	Water	116-121	uroporphyrinogen decarboxylase	Homo sapiens	15-18
12636281-2	2003	The in situ profiler accumulates sulfide from the sediment interstitial water through a diffusive gel onto a AgI binding gel to form black Ag2S.	Water	72-77	angiotensin II receptor type 1	Homo sapiens	139-143
21462032-1	2011	A novel, water-soluble 20-hydroxylecdysono-20,22-phosphoric acid 2 and its sodium salt 3 were designed and synthesized from 20-hydroxylecdysone 1 in six steps and with 67% overall yield.	Water	9-14	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	60-66
12497595-3	2003	The results of the study indicate that: (1) the water molecules at the peptide-solvent interface are organized in an ordered structure similar for the two peptide systems but different from that of the bulk, (2) the peptide structure inhibits diffusion perpendicular to the peptide surface by a factor of 3 to 5 relative to diffusion parallel to the peptide surface, which is comparable to diffusion of bulk water, (3) water in the first solvation shell shows dynamical relaxation on fast (1-2 ps) and slow (10-40 ps) time scales, (4) a novel solvent relaxation master equation is shown to capture the details of the fast relaxation of water in the peptide"s first solvation shell, (5) the interaction between the peptide and the solvent is stronger in the wild type than in the E22Q mutant peptide, in agreement with earlier results obtained from computer simulations [Massi, F.; Straub, J. E. Biophys J 2001, 81, 697] correlated with the observed enhanced activity of the E22Q mutant peptide.	Water	48-53	forkhead box H1	Homo sapiens	484-493
15155720-3	2004	From this structure we propose a mechanism for PP5-mediated hydrolysis of phosphoprotein substrates, which requires the precise positioning of two metal ions within a conserved Asp271-M1:M2-W1-His427-His304-Asp274 catalytic motif (where M1 and M2 are metals and W1 is a water molecule).	Water	270-275	protein phosphatase 5 catalytic subunit	Homo sapiens	47-50
21384809-2	2011	In this paper, we report an unusual nonenzymatic degradation of DNA molecules in the confined water nanofilm on mica substrate.	Water	94-99	MHC class I polypeptide-related sequence A	Homo sapiens	112-116
15284286-3	2004	Toward this end, the expression and regulation of AE1 and SLC26A7 was examined in water deprivation, a condition known to increase the osmolality of the medulla.	Water	82-87	solute carrier family 26 member 7	Rattus norvegicus	58-65
15284286-5	2004	Northern hybridizations demonstrated that in the outer medulla, the mRNA expression of SLC26A7 increased by approximately 300% (P &lt; 0.01 versus control; n = 3), whereas the expression of AE1 decreased by approximately 50% (P &lt; 0.05 versus control, n = 3) in water-deprived rats.	Water	264-269	solute carrier family 26 member 7	Rattus norvegicus	87-94
15284286-7	2004	The expression of SLC26A7 remained unchanged in the kidney cortex and stomach in water deprivation, indicating the specificity of SLC26A7 upregulation in outer medulla.	Water	81-86	solute carrier family 26 member 7	Rattus norvegicus	18-25
12535784-0	2003	Cyclooxygenase-2 mRNA expression is associated with c-fos mRNA expression and transient water ADC reduction detected with diffusion MRI during acute focal ischemia in rats.	Water	88-93	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	0-16
15458252-2	2004	It was shown that the ATPase activity and hemolytic stability of erythrocytes, which characterize the state of cell membranes and the mobility of the near-membrane water phase, depend on the concentration of morphine, and this dependence is wave-like.	Water	164-169	dynein axonemal heavy chain 8	Homo sapiens	22-28
21456682-5	2011	As well, laser-initiated exothermic reactions in suspensions of C with CH(3)NO(2) and particulate Hg(CNO)(2) in H(2)O are shown to result in greatly enhanced photoacoustic signal amplitudes.	Water	112-117	biogenesis of lysosomal organelles complex 1 subunit 4	Homo sapiens	101-104
15283470-1	2004	The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized.	Water	11-16	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	91-94
15283470-3	2004	Reaction of the CsA intermediate with mPEG derivative in the presence of a base provides the desired water-soluble prodrugs.	Water	101-106	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	16-19
15283470-4	2004	As a model, we chose molecular weight 5 kDa mPEG in the reaction with CsA to give water soluble prodrugs.	Water	82-87	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	70-73
14753499-0	2003	Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production.	Water	37-42	aquaporin 1	Mus musculus	0-11
14753499-1	2003	Aquaporin-1 (AQP1) is a water channel that is strongly expressed at the ventricular-facing surface of choroid plexus epithelium.	Water	24-29	aquaporin 1	Mus musculus	0-11
14753499-1	2003	Aquaporin-1 (AQP1) is a water channel that is strongly expressed at the ventricular-facing surface of choroid plexus epithelium.	Water	24-29	aquaporin 1	Mus musculus	13-17
21322552-1	2011	Microbial desalination cell (MDC) is a new method to obtain clean water from brackish water using electricity generated from organic matters by exoelectrogenic bacteria.	Water	66-71	C-C motif chemokine ligand 22	Homo sapiens	29-32
14753499-3	2003	Osmotically-induced water transport was rapid in freshly isolated choroid plexus from wildtype mice as measured by a spatial-filtering optical method, and reduced by 5-fold by AQP1 deletion.	Water	20-25	aquaporin 1	Mus musculus	176-180
15146489-0	2004	Protein-water interactions in ribonuclease A and angiogenin: a molecular dynamics study.	Water	8-13	ribonuclease A family member 1, pancreatic	Homo sapiens	30-44
15146489-0	2004	Protein-water interactions in ribonuclease A and angiogenin: a molecular dynamics study.	Water	8-13	angiogenin	Homo sapiens	49-59
21108456-2	2011	Conjugating PG branches onto beta-CD not only increases its water solubility but also affects its host/guest properties deeply.	Water	60-65	beta-carotene oxygenase 1	Mus musculus	29-36
15146489-4	2004	Extensive molecular dynamics simulations followed by a detailed analysis of protein-water interactions have been carried out on two members of the ribonuclease A superfamily-RNase A and angiogenin.	Water	84-89	ribonuclease A family member 1, pancreatic	Homo sapiens	147-161
15146489-4	2004	Extensive molecular dynamics simulations followed by a detailed analysis of protein-water interactions have been carried out on two members of the ribonuclease A superfamily-RNase A and angiogenin.	Water	84-89	angiogenin	Homo sapiens	186-196
12388456-5	2003	In contrast, plasma aldosterone did not change or increased after drinking; plasma renin activity was elevated by water restriction and increased further after drinking.	Water	114-119	renin	Rattus norvegicus	83-88
22235383-1	2011	Adaptation to high-altitude conditions in rats with experimental renal failure is associated with shifts in the rennin-angiotensin-aldosterone system, which manifested in different serum levels of renin and aldosterone in response to water and salt loads depending on the stage of the compensation processes.	Water	234-239	renin	Rattus norvegicus	197-202
15261042-3	2004	Injected in the subphase buffer of a Langmuir trough, GPx-4 was able to adsorb quickly at the air-water interface whereas the GPx-1 was not.	Water	98-103	glutathione peroxidase 4	Rattus norvegicus	54-59
12797627-2	2003	All classic physiological effects of Ang II, such as vasoconstriction, aldosterone and vasopressin release, sodium and water retention and sympathetic facilitation, are mediated by the AT1 receptor.	Water	119-124	angiotensin II receptor type 1	Homo sapiens	185-188
15078916-2	2004	We previously showed that acid pH or low Ca(2+) increase the water permeability of bovine AQP0 expressed in Xenopus oocytes.	Water	61-66	major intrinsic protein of lens fiber	Bos taurus	90-94
21399723-0	2011	Synthesis, characterization and cytotoxic studies of water soluble [(eta-C(5)H(5))(2)Mo(thionucleobase/thionucleoside)]Cl complexes in breast and colon cancer cell lines.	Water	53-58	endothelin receptor type A	Homo sapiens	69-72
15078916-6	2004	In the killifish AQP0 homologue, MIPfun, with His at position 39 in loop A, alkaline rather than acid pH increased water permeability.	Water	115-120	major intrinsic protein of lens fiber	Bos taurus	17-21
21294856-6	2011	administration of 10 mug of EJHE and EJHE-water residue (WR), prepared from butanol extraction, increased significantly IFN-gamma production in the spleen (p &lt; 0.01) and lung (p &lt; 0.03) tissues at 6-48 hours and suppressed significantly TGF-beta1 production levels (p &lt; 0.001) in the spleen for as long as 48 hours.	Water	42-47	transforming growth factor, beta 1	Mus musculus	243-252
14767772-3	2004	Evidence is provided for an A1AR-mediated tonic inhibition of Na(+) reabsorption in a water-impermeable segment of the loop of Henle, possibly the thick ascending limb.	Water	86-91	adenosine A1 receptor	Mus musculus	28-32
15123901-9	2004	Six (46%) tap water immersions and no (0%) other immersions had inflicted injuries (P = 0.05).	Water	14-19	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	10-13
12815614-9	2003	However, consumption of the antioxidant in drinking water for 3 or 30 days prior to CEES exposure significantly inhibited the induction of TNF-alpha, activation of neutral and acid sphingomyelinases, production of ceramides, activation of caspases, leakage of (125)I-bovine serum albumin ((125)I-BSA) into lung tissue, and histological alterations in lung.	Water	52-57	tumor necrosis factor	Cavia porcellus	139-148
15624322-1	2003	BACKGROUND: Aquaporin-1 (AQ-1) is a transmembrane water channel protein reportedly expressed in continuous capillary endothelium and intestinal lacteals.	Water	50-55	aquaporin 1	Rattus norvegicus	12-23
15624322-1	2003	BACKGROUND: Aquaporin-1 (AQ-1) is a transmembrane water channel protein reportedly expressed in continuous capillary endothelium and intestinal lacteals.	Water	50-55	aquaporin 1	Rattus norvegicus	25-29
15624322-10	2003	Lymph protein is known to concentrate in lymph nodes by fluid loss, so AQ-1 may facilitate lymph to plasma water flux.	Water	107-112	aquaporin 1	Rattus norvegicus	71-75
15123901-11	2004	Of these, one tap water immersion, but no other immersion, was inflicted.	Water	18-23	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	14-17
20658309-2	2011	This study characterizes the different COD fractions of dormitory grey water and investigates the effect of applying different conditions in the biodegradation test.	Water	71-76	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	39-42
15123901-14	2004	Bilateral lower extremity tap water immersion scalds occurred in 100% (6/6) of abusive and 29% (2/7) of unintentional injuries (P = 0.02).	Water	30-35	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	26-29
15123901-15	2004	Buttock and perineal injuries occurred in 67% (4/6) inflicted versus 29% (2/7) unintentional tap water immersion scalds (P = 0.28).	Water	97-102	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	93-96
15048820-4	2004	Altogether, 39, 27, 49, and 32 water molecules bound to the protein were found for trajectories of the free CDK2, CDK2/ATP, CDK2/roscovitine, and CDK2/isopentenyladenine complexes, respectively.	Water	31-36	cyclin dependent kinase 2	Homo sapiens	108-112
15048820-4	2004	Altogether, 39, 27, 49, and 32 water molecules bound to the protein were found for trajectories of the free CDK2, CDK2/ATP, CDK2/roscovitine, and CDK2/isopentenyladenine complexes, respectively.	Water	31-36	cyclin dependent kinase 2	Homo sapiens	114-118
15048820-4	2004	Altogether, 39, 27, 49, and 32 water molecules bound to the protein were found for trajectories of the free CDK2, CDK2/ATP, CDK2/roscovitine, and CDK2/isopentenyladenine complexes, respectively.	Water	31-36	cyclin dependent kinase 2	Homo sapiens	114-118
15048820-4	2004	Altogether, 39, 27, 49, and 32 water molecules bound to the protein were found for trajectories of the free CDK2, CDK2/ATP, CDK2/roscovitine, and CDK2/isopentenyladenine complexes, respectively.	Water	31-36	cyclin dependent kinase 2	Homo sapiens	114-118
15048820-8	2004	In the CDK2/isopentenyladenine complex simulation, two water molecules that arrange interaction between the inhibitor and the enzyme via an H-bond were observed.	Water	55-60	cyclin dependent kinase 2	Homo sapiens	7-11
15048820-9	2004	Two stable water molecules in the trajectory of the free CDK2 were found that occupy the same position as the nitrogens N3 and N9 of the isopentenyladenine or N1 and N6 nitrogens of the adenosine triphosphate (ATP).	Water	11-16	cyclin dependent kinase 2	Homo sapiens	57-61
14610331-0	2003	Association between brain natriuretic peptide and extracellular water in hemodialysis patients.	Water	64-69	natriuretic peptide B	Homo sapiens	20-45
15048820-10	2004	The positions of structural water molecules were compared with the positions of substrate polar groups and crystallographic water molecules found in the Brookhaven Protein Data Bank for various CDK2 complexes.	Water	124-129	cyclin dependent kinase 2	Homo sapiens	194-198
20658309-4	2011	The results show that, on average, dormitory grey water COD fractions are 28% suspended, 32% colloidal and 40% dissolved.	Water	50-55	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	56-59
20691598-4	2011	A CEST effect is observed for both YbL(1) and EuL(1) complexes (B=11.7T), originating from the slow exchange of the amide protons and those of the coordinated water, respectively, whilst no CEST is detected for complexes of L(2).	Water	159-164	DNA polymerase epsilon 3, accessory subunit	Homo sapiens	35-41
15099082-2	2004	Sometimes, the enzyme converts ALL the oxygen into water, without affecting the organic substrate, thereby acting as an "oxidase" (ref 1).	Water	51-56	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	120-136
12760570-2	2003	At first, the ionic interaction between HCS and PAA in distilled water was investigated by means of rheological and turbidimetric analysis.	Water	65-70	holocarboxylase synthetase	Homo sapiens	40-43
21270274-7	2011	Chronic treatment in db/db mice (50 mg/kg/bid; 45 days) reduced postabsorptive glycemia (-38%), water consumption (-31%), and fructosamine (-30%).	Water	96-101	BH3 interacting domain death agonist	Mus musculus	42-45
12372839-1	2002	1-cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily, reduces phospholipid hydroperoxides as well as organic peroxides and H(2)O(2).	Water	144-149	peroxiredoxin 6	Rattus norvegicus	0-19
12372839-1	2002	1-cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily, reduces phospholipid hydroperoxides as well as organic peroxides and H(2)O(2).	Water	144-149	peroxiredoxin 6	Rattus norvegicus	21-29
12372839-1	2002	1-cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily, reduces phospholipid hydroperoxides as well as organic peroxides and H(2)O(2).	Water	144-149	peroxiredoxin 6	Rattus norvegicus	6-19
15875391-2	2004	However, preparing mica surfaces that are truly clean is not easy since mica is a high-energy surface that readily adsorbs water, organic contaminants, and gases from the atmosphere.	Water	123-128	MHC class I polypeptide-related sequence A	Homo sapiens	19-23
15875391-2	2004	However, preparing mica surfaces that are truly clean is not easy since mica is a high-energy surface that readily adsorbs water, organic contaminants, and gases from the atmosphere.	Water	123-128	MHC class I polypeptide-related sequence A	Homo sapiens	72-76
15080704-1	2004	Solid-state NMR measurements were performed on the complex of an 18-residue peptide derived from the V3 loop sequence of the gp120 envelope glycoprotein of the HIV-1 MN strain with Fv fragments of the human anti-gp120 monoclonal antibody 447-52D in a frozen glycerol/water solution.	Water	267-272	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	125-130
20221798-7	2011	The estimated effective doses from drinking water were found to be 2.4 muSv year(-1) (226Ra), 1.1 muSv year(-1) (232Th), and 0.51 muSv year(-1) (40K).	Water	44-49	small nuclear ribonucleoprotein U5 subunit 40	Homo sapiens	145-148
15100044-1	2004	Reduced cytochrome c oxidase binds molecular oxygen, yielding an oxygenated intermediate first (Oxy) and then converts it to water via the reaction intermediates of P, F, and O in the order of appearance.	Water	125-130	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	8-28
12382288-7	2002	Here we report a 3 ns molecular dynamics simulation of RNase A in water aimed at characterizing the dynamical behavior of the enzyme.	Water	66-71	ribonuclease A family member 1, pancreatic	Homo sapiens	55-62
12133842-14	2002	Estimating 14,000 UT-B molecules per mouse erythrocyte, the UT-B-dependent P(f) of 0.15 x 10(-4) cm/s indicated a substantial single channel water permeability of UT-B of 7.5 x 10(-14) cm(3)/s, similar to that of AQP1.	Water	141-146	solute carrier family 14 (urea transporter), member 1	Mus musculus	18-22
21109336-0	2011	Contamination by arsenic and other trace elements of tube-well water along the Mekong River in Lao PDR.	Water	63-68	interleukin 4 induced 1	Homo sapiens	95-98
12133842-14	2002	Estimating 14,000 UT-B molecules per mouse erythrocyte, the UT-B-dependent P(f) of 0.15 x 10(-4) cm/s indicated a substantial single channel water permeability of UT-B of 7.5 x 10(-14) cm(3)/s, similar to that of AQP1.	Water	141-146	solute carrier family 14 (urea transporter), member 1	Mus musculus	60-64
12133842-14	2002	Estimating 14,000 UT-B molecules per mouse erythrocyte, the UT-B-dependent P(f) of 0.15 x 10(-4) cm/s indicated a substantial single channel water permeability of UT-B of 7.5 x 10(-14) cm(3)/s, similar to that of AQP1.	Water	141-146	solute carrier family 14 (urea transporter), member 1	Mus musculus	60-64
12133842-14	2002	Estimating 14,000 UT-B molecules per mouse erythrocyte, the UT-B-dependent P(f) of 0.15 x 10(-4) cm/s indicated a substantial single channel water permeability of UT-B of 7.5 x 10(-14) cm(3)/s, similar to that of AQP1.	Water	141-146	aquaporin 1	Mus musculus	213-217
12133842-15	2002	These results provide direct functional evidence for UT-B-facilitated water transport in erythrocytes and suggest that urea traverses an aqueous pore in the UT-B protein.	Water	70-75	solute carrier family 14 (urea transporter), member 1	Mus musculus	53-57
15095898-7	2004	These results show that CYP1A mRNA determination in the gill, gut, and caudal fin, which are in direct contact with the polluted water, may become a useful method for monitoring CYP1A-inducible chemicals.	Water	129-134	cytochrome P450 1A1	Oryzias latipes	24-29
15095898-7	2004	These results show that CYP1A mRNA determination in the gill, gut, and caudal fin, which are in direct contact with the polluted water, may become a useful method for monitoring CYP1A-inducible chemicals.	Water	129-134	cytochrome P450 1A1	Oryzias latipes	178-183
21118692-9	2011	As the receptor for GPA2/GPB5 stimulates the production of cyclic AMP (cAMP) and is highly expressed in the hindgut, where cAMP stimulates water reabsorption in locusts, it is suggested that GPA2/GPB5 may be an insect anti-diuretic hormone.	Water	139-144	Glycoprotein hormone beta 5	Drosophila melanogaster	25-29
15037113-6	2004	When plated on glass coverslips, plasma membrane osmotic water permeability determined by light scattering was significantly higher for cells from wildtype vs. AQP1 null mice (in microm sec(-1): 74+/-4, n = 19 vs. 44+/-4 microm sec(-1), n = 11, p &lt; 0.001).	Water	57-62	aquaporin 1	Mus musculus	160-164
15037113-8	2004	Thus, as in other "low rate" fluid transporting epithelia, deletion of AQP1 in mice corneal endothelium reduces osmotic water permeability but not active transendothelial fluid transport.	Water	120-125	aquaporin 1	Mus musculus	71-75
12213409-0	2002	Synergistic adjuvant activity of immunostimulatory DNA and oil/water emulsions for immunization with HIV p55 gag antigen.	Water	63-68	membrane protein, palmitoylated	Mus musculus	105-108
21050869-0	2011	A mammalian melanopsin in the retina of a fresh water turtle, the red-eared slider (Trachemys scripta elegans).	Water	48-53	opsin 4	Homo sapiens	12-22
12190307-1	2002	We present new homology-based models of the glutamate binding site (in closed and open forms) of the NMDA receptor NR2B subunit derived from X-ray structures of the water soluble AMPA sensitive glutamate receptor.	Water	165-170	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	115-119
15030409-7	2004	Mitochondrial phospho-ERK1/2 increased at 1 microm hydrogen peroxide (H(2)O(2)) concentration, but it decreased at higher 50-100 microm H(2)O(2), almost disappearing after the organelles were maximally stimulated to produce H(2)O(2) with antimycin.	Water	70-75	mitogen activated protein kinase 3	Rattus norvegicus	22-28
21084312-1	2011	Threonine synthase (TS), which is a pyridoxal 5"-phosphate (PLP)-dependent enzyme, catalyzes the elimination of the gamma-phosphate group from O-phospho-L-homoserine (OPHS) and the subsequent addition of water at Cbeta to form L-threonine.	Water	204-209	threonine synthase	Thermus thermophilus HB8	0-18
15095558-1	2004	Continuous arterial spin labeling perfusion magnetic resonance imaging (CASL-pMRI) uses magnetically labeled arterial blood water as a tracer to obtain quantifiable measurements of cerebral blood flow (CBF) (mL/100 g-1/min-1).	Water	124-129	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	72-76
12099296-2	2002	DSC studies on these materials, swollen in water.	Water	43-48	desmocollin 3	Homo sapiens	0-3
21084312-1	2011	Threonine synthase (TS), which is a pyridoxal 5"-phosphate (PLP)-dependent enzyme, catalyzes the elimination of the gamma-phosphate group from O-phospho-L-homoserine (OPHS) and the subsequent addition of water at Cbeta to form L-threonine.	Water	204-209	threonine synthase	Thermus thermophilus HB8	20-22
21084312-5	2011	Global analysis of the spectral changes in the reaction of TS with L-threonine showed that compared with the more acidic sulfate ion, the phosphate ion decreased the energy levels of the transition states of the addition of water at the Cbeta of the PLP-alpha-aminocrotonate aldimine (AC) and the transaldimination to form L-threonine.	Water	224-229	threonine synthase	Thermus thermophilus HB8	59-61
15065241-5	2004	Consistent with the pathologic changes, the fat/water ratios estimated by the MR technique increased significantly at doses of 1 mg/kg and 100 mg/kg of MTP inhibitor after 14 days of continuous administration.	Water	48-53	microsomal triglyceride transfer protein	Rattus norvegicus	152-155
20940086-1	2011	Reactive Red 2 through photocatalysis coupled with water jet cavitation.	Water	51-56	adenosine deaminase RNA specific B2 (inactive)	Homo sapiens	9-14
15012112-2	2004	Recent studies have suggested that hydroperoxy radicals (HO2) have an affinity for binding to a water surface.	Water	96-101	heme oxygenase 2	Homo sapiens	57-60
15012112-4	2004	The analyses reveal that, for the binding of an HO2 radical to a water surface, the two water molecules nearest the radical are the most relevant to the bonding and the addition of other water molecules has little affect on the bonding between the radical and the two nearest waters.	Water	65-70	heme oxygenase 2	Homo sapiens	48-51
15012112-4	2004	The analyses reveal that, for the binding of an HO2 radical to a water surface, the two water molecules nearest the radical are the most relevant to the bonding and the addition of other water molecules has little affect on the bonding between the radical and the two nearest waters.	Water	88-93	heme oxygenase 2	Homo sapiens	48-51
15012112-4	2004	The analyses reveal that, for the binding of an HO2 radical to a water surface, the two water molecules nearest the radical are the most relevant to the bonding and the addition of other water molecules has little affect on the bonding between the radical and the two nearest waters.	Water	88-93	heme oxygenase 2	Homo sapiens	48-51
15060711-8	2004	The exercise-related differences in SBP, DP and Tsk between HY and NO were increased by water ingestion (P&lt;0.05).	Water	88-93	selenium binding protein 1	Homo sapiens	36-39
15202613-1	2004	PURPOSE OF REVIEW: "New" tasks have been discovered for aldosterone and its receptor, the mineralocorticoid receptor, within both epithelial tissues of vectorial ion and water transport, such as the kidney, and non-epithelial organs, including the brain, heart and vessels.	Water	170-175	nuclear receptor subfamily 3 group C member 2	Homo sapiens	90-116
14998751-11	2004	Tap water was devoid of hormonal activity.	Water	4-9	tracheal antimicrobial peptide	Bos taurus	0-3
14978158-13	2004	Both ang1 and VEGF modulate GEnC barrier properties, consistent with potential in vivo roles; ang1 stabilizing the endothelium and resisting angiogenesis while VEGF induces the high permeability to water, characteristic of the glomerular endothelium.	Water	198-203	angiopoietin 1	Homo sapiens	5-9
14998683-1	2004	The drinking water disinfection byproduct bromodichloromethane (CHBrCl(2)) was previously shown to be mutagenic in Salmonella typhimurium that overexpress rat glutathione transferase theta 1-1 (GSTT1-1).	Water	13-18	glutathione S-transferase theta 1	Rattus norvegicus	194-201
15252529-2	2004	Treatment of [Ru(trpy)(PD-N,N")Cl](PF6) with AgClO4 in a mixed solvent of acetone and H2O selectively produced the acetonyl-PD complex [1](ClO4)2, and the similar treatment in a mixed solvent of 2-methoxyethanol and H2O gave the PD complex [2](ClO4)2.	Water	86-89	sperm associated antigen 17	Homo sapiens	35-38
15252529-2	2004	Treatment of [Ru(trpy)(PD-N,N")Cl](PF6) with AgClO4 in a mixed solvent of acetone and H2O selectively produced the acetonyl-PD complex [1](ClO4)2, and the similar treatment in a mixed solvent of 2-methoxyethanol and H2O gave the PD complex [2](ClO4)2.	Water	216-219	sperm associated antigen 17	Homo sapiens	35-38
15803708-0	2004	Interaction of water with self-assembled monolayers of alkylsilanes on mica.	Water	15-20	MHC class I polypeptide-related sequence A	Homo sapiens	71-75
15803708-1	2004	The interaction of water with self-assembled alkylsilane monolayers on mica substrates has been studied using an atomic force microscope operated in contact, noncontact, and electrical polarization modes.	Water	19-24	MHC class I polypeptide-related sequence A	Homo sapiens	71-75
15803708-3	2004	On partially covered surfaces water was found to produce large changes in the conductivity and surface potential of the exposed mica regions.	Water	30-35	MHC class I polypeptide-related sequence A	Homo sapiens	128-132
14972715-12	2004	When lysozyme and/or mucin were added to the aqueous solution, hysteresis was eliminated, and equivalent and high water wetting was achieved for the three lenses.	Water	114-119	LOC100508689	Homo sapiens	21-26
15384792-1	2004	Aquaporin-1 (AQP1) has been reported to play an important role in water permeability in peritoneal dialysis.	Water	66-71	aquaporin 1	Rattus norvegicus	0-11
15384792-1	2004	Aquaporin-1 (AQP1) has been reported to play an important role in water permeability in peritoneal dialysis.	Water	66-71	aquaporin 1	Rattus norvegicus	13-17
14713391-7	2004	Faecal elastase-1 (inversely) and chymotrypsin (directly) were significantly associated with percentage faecal free water content in subjects without pancreatic disease.	Water	116-121	chymotrypsin like elastase 1	Homo sapiens	7-17
14752829-6	2004	In nontransfected NMCs, the transcellular water flow, P(f), value was relatively high (i.e., 16.4 +/- 3.2 microm/sec) and likely was a reflection of endogenous expression of AQP1 and AQP8.	Water	42-47	aquaporin 1	Mus musculus	174-178
15658611-4	2004	Water extract of BHT significantly promoted in vitro proliferative responses of mouse spleen cells (SPC) and also further enhanced the proliferation of SPC stimulated with anti-CD3 antibody.	Water	0-5	CD3 antigen, epsilon polypeptide	Mus musculus	177-180
15323352-3	2004	It was found that this water channel was present in the myometrium of the pregnant rat uterus with the intensity of AQP1 immunoreactivity increasing from day 1 to day 6 of pregnancy.	Water	23-28	aquaporin 1	Rattus norvegicus	116-120
15561418-3	2004	For example, the Na(+)-glutamate cotransporter (EAAT1) has a unit water permeability one tenth of that of aquaporin (AQP) 1.	Water	66-71	solute carrier family 1 member 3 L homeolog	Xenopus laevis	48-53
15561418-3	2004	For example, the Na(+)-glutamate cotransporter (EAAT1) has a unit water permeability one tenth of that of aquaporin (AQP) 1.	Water	66-71	aquaporin	Xenopus laevis	106-115
15370465-6	2004	There were no significant differences between HGF levels using phosphate buffered saline (PBS) (pH 7.4) or NaCL as buffer, but it was observed that levels of HGF were significantly lower in the samples that were diluted in distilled water.	Water	233-238	hepatocyte growth factor	Homo sapiens	158-161
15063831-0	2004	Inhibitory effects of Polygonum cuspidatum water extract (PCWE) and its component resveratrol [correction of rasveratrol] on acyl-coenzyme A-cholesterol acyltransferase activity for cholesteryl ester synthesis in HepG2 cells.	Water	43-48	carboxylesterase 1	Homo sapiens	125-168
14664511-2	2003	In the preliminary study, the antioxidant potential of a hot-water extract obtained from the dried fruit of C. pinnatifida (CF-H) was evaluated in terms of its capacity of quenching 1,1-diphenyl-2-picrylhydrazyl free radicals (EC(50) = 0.118 mg/mL).	Water	61-66	complement component factor h	Mus musculus	124-128
14637313-5	2003	AQP1 deletion significantly decreased osmotic water transport in pleural space by twofold, but it had no effect on isosmolar fluid clearance.	Water	46-51	aquaporin 1	Mus musculus	0-4
14588144-2	2003	Treatment of BAEC with 1 mM H(2)O(2) caused increases of DNA fragmentation, p53 expression, Bax/Bcl-2 ratio, and the activities of caspases 3 and 9.	Water	28-33	caspase 3	Bos taurus	131-147
15031899-11	2003	There were 147 water patches, with an area of 149.93 hm2, and occupied 8.54% of land, and the average and maximum area of the patch was 1.02 hm2 and 16 hm2, respectively.	Water	15-20	cholinergic receptor muscarinic 2	Homo sapiens	53-56
14581168-1	2003	The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria.	Water	44-49	monoamine oxidase A	Rattus norvegicus	128-131
14581168-1	2003	The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria.	Water	44-49	monoamine oxidase A	Rattus norvegicus	133-138
14581168-1	2003	The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria.	Water	55-60	monoamine oxidase A	Rattus norvegicus	128-131
14581168-1	2003	The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria.	Water	55-60	monoamine oxidase A	Rattus norvegicus	133-138
12128172-5	2002	TGA showed that the commercial samples are dihydrate and the sample prepared from water/ethanol (1:1) was a monohydrate.	Water	82-87	T-box transcription factor 1	Homo sapiens	0-3
12081491-8	2002	Finally, this work emphasizes the essential role of colipase in lipase catalysis at the lipid-water interface in the presence of bile.	Water	94-99	colipase	Equus caballus	52-60
12077365-7	2002	SPARC-null lenses at 1 month of age exhibited an increased penetration of dye or radioactive tracer through the capsule, as well as a higher content of water than their wild-type counterparts.	Water	152-157	secreted acidic cysteine rich glycoprotein	Mus musculus	0-5
12083555-6	2002	The results from DSC and NMR measurements show that the bound state of H2O in PEO, as well as the mobility of PEO itself, varies according to the water content in PEO-H2O samples.	Water	71-74	desmocollin 3	Homo sapiens	17-20
12083555-6	2002	The results from DSC and NMR measurements show that the bound state of H2O in PEO, as well as the mobility of PEO itself, varies according to the water content in PEO-H2O samples.	Water	146-151	desmocollin 3	Homo sapiens	17-20
12083555-6	2002	The results from DSC and NMR measurements show that the bound state of H2O in PEO, as well as the mobility of PEO itself, varies according to the water content in PEO-H2O samples.	Water	167-170	desmocollin 3	Homo sapiens	17-20
12083555-7	2002	On the other hand, DSC measurements give the result that PEO-H2O-HQ systems can be considered as homogeneous so long as the content of H2O and/or HQ is not so high.	Water	61-64	desmocollin 3	Homo sapiens	19-22
12083555-7	2002	On the other hand, DSC measurements give the result that PEO-H2O-HQ systems can be considered as homogeneous so long as the content of H2O and/or HQ is not so high.	Water	135-138	desmocollin 3	Homo sapiens	19-22
12083555-9	2002	Results of high-frequency spectroscopic measurements for the PEO-H2O and PEO-H2O-HQ systems show good agreement with those of DSC and NMR measurements.	Water	77-80	desmocollin 3	Homo sapiens	126-129
11982446-3	2002	METHODS: By means of positron emission tomography with oxygen 15-labeled water, rCBF was assessed in 18 previously untreated patients with social phobia during an anxiogenic public speaking task.	Water	73-78	CCAAT/enhancer binding protein zeta	Rattus norvegicus	80-84
12008205-1	2002	BNP7787 (2",2"-dithio-bis-ethane sulphonate sodium), a water-soluble disulphide, is chemically and mechanistically different from other sulphur-containing chemoprotective agents.	Water	55-60	natriuretic peptide B	Homo sapiens	0-3
12021528-15	2002	The induction of NHE-3 is independent of the nature of colitides, and might be important to compensate for the loss of electrolyte and water in experimental colitis.	Water	135-140	solute carrier family 9 member A3	Rattus norvegicus	17-22
12012207-2	2002	Recently, intense signal for mRNA of aquaporin 1 (AQP1) water channels was detected in isolated rat interlobular ducts.	Water	56-61	aquaporin 1	Rattus norvegicus	37-48
12012207-2	2002	Recently, intense signal for mRNA of aquaporin 1 (AQP1) water channels was detected in isolated rat interlobular ducts.	Water	56-61	aquaporin 1	Rattus norvegicus	50-54
12012207-14	2002	These results indicate that the expression and subcellular localization of AQP1 vary considerably depending on the duct size, which may reflect water transport characteristics in the different divisions of the pancreatic duct system.	Water	144-149	aquaporin 1	Rattus norvegicus	75-79
11923212-4	2002	Interestingly, the Inv-Cldn6 transgenic animals die within 2 days of birth, apparently due to the lack of an intact EPB as evidenced by increased water loss and the penetration of X-gal through the skin.	Water	146-151	involucrin	Mus musculus	19-22
11923212-4	2002	Interestingly, the Inv-Cldn6 transgenic animals die within 2 days of birth, apparently due to the lack of an intact EPB as evidenced by increased water loss and the penetration of X-gal through the skin.	Water	146-151	claudin 6	Mus musculus	23-28
11952783-11	2002	The cRNA injection of the missense mutants into Xenopus oocytes revealed the absence of the activity to transport glycerol and water in the AQPap-G264V protein.	Water	127-132	aquaporin 7	Homo sapiens	140-145
11879013-5	2002	The enzymatically generated water-soluble dextrins (maltose and DP3, DP4, DP5, and DP6 dextrins) are the most effective in preserving crumb softness during bread storage.	Water	28-33	APC regulator of WNT signaling pathway	Homo sapiens	64-67
11879013-5	2002	The enzymatically generated water-soluble dextrins (maltose and DP3, DP4, DP5, and DP6 dextrins) are the most effective in preserving crumb softness during bread storage.	Water	28-33	harakiri, BCL2 interacting protein	Homo sapiens	74-77
11814838-1	2002	A series of water soluble N(1)- and C(6)-substituted uracil pyridinium compounds were prepared as potential inhibitors of thymidine phosphorylase (TP).	Water	12-17	thymidine phosphorylase	Homo sapiens	122-145
14581168-7	2003	These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system.	Water	104-109	monoamine oxidase A	Rattus norvegicus	58-63
12944406-8	2003	Since mannitol is commonly used to reduce brain edema, understanding the regulation of AQPs and p38 MAPK in astrocytes under hyperosmotic conditions induced with mannitol may lead to a control of water movements and a new treatment for brain edema.	Water	196-201	mitogen activated protein kinase 14	Rattus norvegicus	96-99
20940086-3	2011	Reactive Red 2 was investigated using TiO(2) photocatalysis coupled with water jet cavitation.	Water	73-78	adenosine deaminase RNA specific B2 (inactive)	Homo sapiens	9-14
14674525-6	2003	If the degree of corrosion and cementation that was observed from 15 to 30 mo after installation continues, certain portions of the PRB (i.e., up-gradient entrance of the ground water to the Fe0 section of the PRB) may last less than five more years, thus reducing the effectiveness of the PRB to mitigate contaminants.	Water	178-183	RB transcriptional corepressor 1	Homo sapiens	132-135
21042611-2	2011	The Coulomb contribution for the interaction potential was damped by a factor eta varied from 1 to 0.49 for water and 1 to 0.15 for methanol.	Water	108-113	endothelin receptor type A	Homo sapiens	78-81
12939143-3	2003	Studies with animal models suggested that APJ and apelin play an important role in the hypothalamic regulation of water intake and the endocrine axis, in the regulation of blood pressure, and in cardiac contractility.	Water	114-119	apelin receptor	Homo sapiens	42-45
12924946-0	2003	NMR solution structure of attractin, a water-borne protein pheromone from the mollusk Aplysia californica.	Water	39-44	attractin	Aplysia californica	26-35
21721151-5	2011	Furthermore, the water extract, but not the ethanol extract, of ES dose-dependently inhibited LPS-induced JNK, p38 mitogen-activated protein kinases (MAPK), and slightly inhibited cyclooxygenase (COX-2) in BV-2 cells but decreased p38 MAPK and COX-2 expressions in the liver of LPS-treated rats.	Water	17-22	cytochrome c oxidase II, mitochondrial	Mus musculus	196-201
21721151-5	2011	Furthermore, the water extract, but not the ethanol extract, of ES dose-dependently inhibited LPS-induced JNK, p38 mitogen-activated protein kinases (MAPK), and slightly inhibited cyclooxygenase (COX-2) in BV-2 cells but decreased p38 MAPK and COX-2 expressions in the liver of LPS-treated rats.	Water	17-22	mitogen-activated protein kinase 14	Mus musculus	231-239
12876347-2	2003	The LolA protein, a periplasmic chaperone functioning as an outer-membrane lipoprotein carrier of the Lol system which mediates translocation of the water-insoluble outer-membrane lipoprotein across the periplasm in Gram-negative bacteria, was crystallized in two forms: orthorhombic (I222) and trigonal (P3(1)21 or P3(2)21).	Water	149-154	lysyl oxidase like 1	Homo sapiens	4-7
21721151-5	2011	Furthermore, the water extract, but not the ethanol extract, of ES dose-dependently inhibited LPS-induced JNK, p38 mitogen-activated protein kinases (MAPK), and slightly inhibited cyclooxygenase (COX-2) in BV-2 cells but decreased p38 MAPK and COX-2 expressions in the liver of LPS-treated rats.	Water	17-22	cytochrome c oxidase II, mitochondrial	Mus musculus	244-249
21036918-5	2011	Extracellular IL-16 protein was increased in cell-free BAL fluid from chronic smokers and in human blood CD8(+) cells exposed to water-soluble tobacco smoke components in vitro.	Water	129-134	interleukin 16	Homo sapiens	14-19
12869192-9	2003	In CDK2, each of the four bromine atoms makes polar contacts either to main chain oxygens in the hinge region of the kinase or to water molecules, in addition to several van der Waals contacts.	Water	130-135	cyclin dependent kinase 2	Homo sapiens	3-7
21036918-7	2011	A marker of activation (CD69) was slightly increased, whereas other markers of key cellular functions (membrane integrity, apoptosis, and proliferation) in human blood CD8(+) cells in vitro were negatively affected by water-soluble tobacco smoke components.	Water	218-223	CD69 molecule	Homo sapiens	24-28
21404492-8	2011	Following Longo et al, the concentration of fat phi(fat), was calculated from the signal intensities of water and triglycerides.	Water	104-109	FAT atypical cadherin 1	Homo sapiens	44-47
12860309-4	2003	Oral administration of the water extract (125 and 250mgkg(-1)) twice a day for 4 weeks resulted in significant reductions in blood glucose, plasma thiobarbituric acid reactive substances, hydroperoxides, ceruloplasmin and alpha-tocopherol and a significant elevation in plasma reduced glutathione and Vitamin C in diabetic rats.	Water	27-32	ceruloplasmin	Rattus norvegicus	204-217
21404492-8	2011	Following Longo et al, the concentration of fat phi(fat), was calculated from the signal intensities of water and triglycerides.	Water	104-109	FAT atypical cadherin 1	Homo sapiens	52-55
21112052-6	2011	RESULTS: Controlling for age of housing, LSL was an independent risk factor for BLLs &gt;= 10 mug/dL, and &gt;= 5 mug/dL even during time periods when water levels met the US Environmental Protection Agency (EPA) action level of 15 parts per billion (ppb).	Water	151-156	LEPQTL1	Homo sapiens	41-44
14612181-1	2003	Mate attraction in Aplysia involves long-distance water-borne signaling via the secretion of the peptide pheromone attractin from the exocrine albumen gland during egg laying.	Water	50-55	attractin	Aplysia californica	115-124
12874007-3	2003	For this purpose, a water-soluble maleimide derivative of doxorubicin (1) incorporating a MMP-2 specific peptide sequence (Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln) was developed that binds rapidly and selectively to the cysteine-34 position of circulating albumin.	Water	20-25	matrix metallopeptidase 2	Homo sapiens	90-95
21134126-0	2011	Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for "ping pong" kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione.	Water	222-227	S100 calcium binding protein A10 (calpactin)	Mus musculus	59-63
22272109-9	2011	Taken together, these results suggest that the increase in GSH level by Jeju ground water is, at least in part, due to the effects of vanadyl sulfate via the Nrf2-mediated induction of GCLC.	Water	84-89	glutamate-cysteine ligase catalytic subunit	Homo sapiens	185-189
21040272-7	2011	The presence of greater amount of the salt (50 g l(-1) ) resulted in a higher thermal stability of bacteriocin P34, suggesting that the reduction in water activity of the solution interfered on the stability of the peptide.	Water	149-154	alpha and gamma adaptin binding protein	Homo sapiens	111-114
11829510-10	2002	When numerous water molecules occur within the cup, however, then the phosphate group of PLP participates directly in the enzymatic reactions with inorganic phosphate replacing the water molecules of the cup.	Water	14-19	pyridoxal phosphatase	Homo sapiens	89-92
11829510-10	2002	When numerous water molecules occur within the cup, however, then the phosphate group of PLP participates directly in the enzymatic reactions with inorganic phosphate replacing the water molecules of the cup.	Water	181-186	pyridoxal phosphatase	Homo sapiens	89-92
22174795-1	2011	Aquaporin-1 (AQP1) is a water channel that is highly expressed in tissues with rapid O(2) transport.	Water	24-29	aquaporin 1	Mus musculus	0-11
11804854-10	2002	AQP1 of the known AQPs appears to be the main water pathway in interlobular ducts.	Water	46-51	aquaporin 1	Rattus norvegicus	0-4
11858955-3	2002	After the treatment of keratinocytes with 300 microM H(2)O(2), a translocation of NF-kappaB from the cytoplasm to nucleus was observed in an immunofluorescence study using anti-human NF-kappaB1 and anti-human RelA antibodies.	Water	53-58	RELA proto-oncogene, NF-kB subunit	Homo sapiens	209-213
11784860-1	2002	We have constructed an ALDH3a1 null mouse to investigate the role of this enzyme that comprises nearly one-half of the total water-soluble protein in the mouse corneal epithelium.	Water	125-130	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	23-30
11784860-2	2002	ALDH3a1-deficient mice are viable and fertile, have a corneal epithelium with a water-soluble protein content approximately half that of wild-type mice, and contain no ALDH3a1 as determined by zymograms and immunoblots.	Water	80-85	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	0-7
11833743-5	2002	EGF-treated group markedly enhanced the water absorption and induction of sodium glucose cotransporter (SGLTI) as compared with EGF-untreated group.	Water	40-45	epidermal growth factor like 1	Rattus norvegicus	0-3
12381934-6	2002	COX-2 appears to play an important role in promoting free water excretion in the fetal lamb.	Water	58-63	cytochrome c oxidase subunit II	Ovis aries	0-5
12751910-4	2002	Quantitative Structure-Activity Relationships (QSARs) for substrates binding to CYP2B6 indicate a key role for hydrogen bonding, and lipophilic character, as determined by the log P parameter (where P is the octanol/water partition coefficient), is also of importance for explaining the variation in experimental binding affinity for CYP2B6 substrates.	Water	216-221	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	80-86
12590200-6	2002	RESULTS: The outward-directed current was fully abolished by incubation with 1 mM ouabain and was significantly larger in oocytes expressing (S422D)SGK1, SGK1, SGK2 or SGK3, as compared to those injected with water.	Water	209-214	serum/glucocorticoid regulated kinase 1 S homeolog	Xenopus laevis	160-164
11912930-5	2002	The active site of MnSOD is dominated by a hydrogen bond network comprising the manganese-bound aqueous ligand, the side chains of four residues (Gln-143, Tyr-34, His-30, and Tyr-166 from an adjacent subunit), as well as other water molecules.	Water	227-232	superoxide dismutase 2	Homo sapiens	19-24
11737588-12	2001	The addition of 1% calcium gluconate to the drinking water significantly reduced STC mRNA levels in inner medullary CD cells of both males and females, but not those in the cortex and outer medulla.	Water	53-58	stanniocalcin 1	Homo sapiens	81-84
11778698-5	2001	Furthermore, the M118L protein associated with the IMV can be surface labeled with water-soluble biotin and is released from the purified IMV with treatment of nonionic detergent NP-40, indicating that the M118L protein is associated with the outer membrane of myxoma IMV.	Water	83-88	IMV membrane protein	Myxoma virus	17-22
11778698-5	2001	Furthermore, the M118L protein associated with the IMV can be surface labeled with water-soluble biotin and is released from the purified IMV with treatment of nonionic detergent NP-40, indicating that the M118L protein is associated with the outer membrane of myxoma IMV.	Water	83-88	IMV membrane protein	Myxoma virus	206-211
11791850-7	2001	The equilibrium PAH concentrations in the leach water from bitumens stay well below the surface water limits that exist in several EEC-countries and are also more than an order of magnitude lower than the current EEC limits for potable water.	Water	48-53	phenylalanine hydroxylase	Homo sapiens	16-19
11791850-7	2001	The equilibrium PAH concentrations in the leach water from bitumens stay well below the surface water limits that exist in several EEC-countries and are also more than an order of magnitude lower than the current EEC limits for potable water.	Water	96-101	phenylalanine hydroxylase	Homo sapiens	16-19
11791850-7	2001	The equilibrium PAH concentrations in the leach water from bitumens stay well below the surface water limits that exist in several EEC-countries and are also more than an order of magnitude lower than the current EEC limits for potable water.	Water	96-101	phenylalanine hydroxylase	Homo sapiens	16-19
11704264-4	2001	DBI suppressed the intake of 5% sucrose, water and 0.9 mM quinine-HCl and the preference for 0.05% saccharin.	Water	41-46	diazepam binding inhibitor	Mus musculus	0-3
11719968-0	2001	Water immersion pretreatment decreases pro-inflammatory cytokine production in cholecystokinin-octapeptide-induced acute pancreatitis in rats: possible role of HSP72.	Water	0-5	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	160-165
11795758-5	2001	Overall, untreated surface waters may represent a source of contamination with Campylobacter spp.	Water	27-33	histocompatibility minor 13	Homo sapiens	93-96
11642446-5	2001	Phenol structures in natural fulvic acids in DOM isolated from groundwater produced significant trihalomethanes (THM) and total organic halogen (TOX) yields upon chlorination, and these structures also were responsible for the enhanced SUVA and specific fluorescence characteristics relative to DOM in reclaimed water.	Water	69-74	thymocyte selection associated high mobility group box	Homo sapiens	145-148
11447217-2	2001	Decreased phosphorylation of focal adhesion kinase (FAK) is associated with loss of focal adhesions and actin stress fibers and precedes the onset of apoptosis in renal epithelial cells caused by nephrotoxicants (Van de Water, B., Nagelkerke, J. F., and Stevens, J. L. (1999) J. Biol.	Water	220-225	focal adhesion kinase	Sus scrofa	29-50
11447217-2	2001	Decreased phosphorylation of focal adhesion kinase (FAK) is associated with loss of focal adhesions and actin stress fibers and precedes the onset of apoptosis in renal epithelial cells caused by nephrotoxicants (Van de Water, B., Nagelkerke, J. F., and Stevens, J. L. (1999) J. Biol.	Water	220-225	focal adhesion kinase	Sus scrofa	52-55
11515650-5	2001	The absorbed dose in water measured in Rhizophora spp at d(max) for all three beams produces discrepancies of no more than 1.1% when compared with measurements made in water.	Water	21-26	histocompatibility minor 13	Homo sapiens	50-53
11509366-1	2001	We determined the influence of the two hydrophobic proteins, SP-B and SP-C, on the thermodynamic barriers that limit adsorption of pulmonary surfactant to the air-water interface.	Water	163-168	surfactant protein C	Bos taurus	70-74
11511035-0	2001	Water-soluble covalent conjugates of bovine serum albumin with anionic poly(N-isopropyl-acrylamide) and their immunogenicity.	Water	0-5	albumin	Mus musculus	44-57
11511035-1	2001	We have conjugated bovine serum albumin (BSA) to poly(N-isopropylacrylamide-co-acrylic acid) (poly(NIPAAm-AA)) by using water-soluble carbodiimide, and the effects of the bulk mass ratio of protein to polymer (r) on the formation of polymer-protein conjugates have been studied.	Water	120-125	albumin	Mus musculus	26-39
11571491-11	2001	Water and sodium depletion and water, NaCl and food deprivation induced sodium appetite, which in the short term depends on cerebral angiotensinergic activity mediated by the activation of AT1 receptors.	Water	0-5	angiotensin II receptor, type 1a	Rattus norvegicus	189-192
11571491-11	2001	Water and sodium depletion and water, NaCl and food deprivation induced sodium appetite, which in the short term depends on cerebral angiotensinergic activity mediated by the activation of AT1 receptors.	Water	31-36	angiotensin II receptor, type 1a	Rattus norvegicus	189-192
11425865-6	2001	In a molecular model of IKCa1, Thr(250) and Val(275) line a water-filled cavity just below the selectivity filter.	Water	60-65	potassium calcium-activated channel subfamily N member 4	Homo sapiens	24-29
12855358-7	2003	The above finding suggests that AQP1 may play a role in the water distribution associated with vigorous ion transport in the stria vascularis since the intermediate part of the stria vascularis contains both intermediate cells and the basolateral parts of marginal cells, both of which express ion transporters abundantly.	Water	60-65	aquaporin 1	Rattus norvegicus	32-36
12931885-2	2003	Corrosion of Fe(0) filings and the formation of precipitates can occur when the PRB material comes in contact with ground water and may reduce the lifespan and effectiveness of the barrier.	Water	122-127	RB transcriptional corepressor 1	Homo sapiens	80-83
12783566-0	2003	Imaging structured water and bound polysaccharide on mica surface at ambient temperature.	Water	19-24	MHC class I polypeptide-related sequence A	Homo sapiens	53-57
12783566-1	2003	The presence of a water layer on the surface of muscovite mica under ambient conditions is well established.	Water	18-23	MHC class I polypeptide-related sequence A	Homo sapiens	58-62
12783566-2	2003	The water molecules are well ordered and seem to be oriented, leading to an icelike monolayer (probably ferroelectric) in epitaxial relation with the mica surface.	Water	4-9	MHC class I polypeptide-related sequence A	Homo sapiens	150-154
12783566-3	2003	We have imaged and characterized the height and contact angle of ordered water layer(s) formed by wetting and de-wetting processes on mica surfaces at different states of hydration by tapping mode atomic force microscopy.	Water	73-78	MHC class I polypeptide-related sequence A	Homo sapiens	134-138
12964784-7	2003	CONCLUSION: Antibodies purified by SPA method are better than those by CAASP method, and Met monoclonal antibodies purified by SPA method can be used to prepare gold-labelled testing paper for analyzing Met residue in vegetable and drink water.	Water	238-243	surfactant protein A1	Homo sapiens	127-130
12833984-7	2003	The average activity concentrations of 40K are dependent on the water"s origin, i.e. meteoric water mixed with sea water (Gulf of Suez springs) and meteoric water (Bahariya Oasis wells).	Water	64-69	small nuclear ribonucleoprotein U5 subunit 40	Homo sapiens	39-42
12833984-7	2003	The average activity concentrations of 40K are dependent on the water"s origin, i.e. meteoric water mixed with sea water (Gulf of Suez springs) and meteoric water (Bahariya Oasis wells).	Water	94-99	small nuclear ribonucleoprotein U5 subunit 40	Homo sapiens	39-42
12788379-9	2003	The MEK1/2 inhibitor U0126 prevented the hypertrophic effect of 10 microM H(2)O(2).	Water	74-79	mitogen activated protein kinase kinase 1	Rattus norvegicus	4-10
12686552-5	2003	The crystal structure of a Smad3 MH1 domain bound to a palindromic DNA sequence, determined at 2.4-A resolution, reveals a surprisingly important role for water molecules.	Water	155-160	SMAD family member 3	Homo sapiens	27-32
12686552-7	2003	These water molecules make specific hydrogen bonds to the DNA bases, the DNA phosphate backbones, and several critical Smad3 residues.	Water	6-11	SMAD family member 3	Homo sapiens	119-124
22174795-1	2011	Aquaporin-1 (AQP1) is a water channel that is highly expressed in tissues with rapid O(2) transport.	Water	24-29	aquaporin 1	Mus musculus	13-17
22174795-4	2011	Stopped-flow light-scattering experiments confirmed an increase in the water permeability of 9L cells exposed to hypoxia, supporting the view that hypoxic Aqp1 up-regulation has a functional role.	Water	71-76	aquaporin 1	Mus musculus	155-159
22022488-8	2011	Enthalpy-entropy compensation was observed for the interaction of PDC-109 with phospholipid membranes, suggesting that water structure plays an important role in the binding process.	Water	119-124	seminal plasma protein PDC-109	Bos taurus	66-73
12598535-6	2003	Measuring the time course of Cdc42 activation and H(2)O(2) production upon ethanol stimulation revealed that the Cdc42 activation and the increase of H(2)O(2) lasted more than 3 h, which indicates the mechanisms of the long duration effects of ethanol on the cells.	Water	50-55	cell division cycle 42	Mus musculus	113-118
12600999-1	2003	Aquaporin-1 (AQP1) is a water channel that is induced by hypertonicity.	Water	24-29	aquaporin 1	Mus musculus	0-11
12600999-1	2003	Aquaporin-1 (AQP1) is a water channel that is induced by hypertonicity.	Water	24-29	aquaporin 1	Mus musculus	13-17
11525742-3	2001	Sod and Cat constitute an evolutionary conserved ROS defense system against superoxide; Sod converts superoxide anions to H(2)O(2), and Cat prevents free hydroxyl radical formation by breaking down H(2)O(2) into oxygen and water.	Water	223-228	Superoxide dismutase 1	Drosophila melanogaster	0-3
11525742-3	2001	Sod and Cat constitute an evolutionary conserved ROS defense system against superoxide; Sod converts superoxide anions to H(2)O(2), and Cat prevents free hydroxyl radical formation by breaking down H(2)O(2) into oxygen and water.	Water	223-228	Superoxide dismutase 1	Drosophila melanogaster	88-91
21287392-8	2011	The high fluoride concentration in water usually reflects the solubility of fluoride (CaF2).	Water	35-40	CCR4-NOT transcription complex subunit 8	Homo sapiens	86-90
11470088-3	2001	While BHA is water soluble at neutral pH and is known to bind to membranes via specific interactions with a viral receptor, FHA2 can only be solubilized in water with an appropriate detergent.	Water	156-161	FHII	Homo sapiens	124-128
12734807-4	2003	The formation of SHAp occurred more rapidly in Hank"s solution and distilled water than in serum.	Water	77-82	shroom family member 4	Homo sapiens	17-21
21053213-12	2010	The reaction of the {[UO(2)(salen)(4)][mu(8)-K](2)[K([18]C-6)](2)} tetramer with protons leads to disproportionation to U(IV) and U(VI) species and H(2)O confirming the crucial role of the proton in the U(V) disproportionation.	Water	148-153	complement C6	Homo sapiens	57-60
12803085-6	2003	In both cases, data obtained allowed the microviscosity of the aqueous interior at different omega 0 to be extrapolated and indicate an increase in eta w values with water content, reflecting changes in the shape of Trx-100 microemulsions, which occur at omega 0 = 8.	Water	166-171	endothelin receptor type A	Homo sapiens	148-151
11686306-3	2001	Video microscopy of cells expressing GFP-DdRab11 revealed that this Rab was associated with contractile vacuolar bladders undergoing formation, fusion and expulsion of water.	Water	168-173	RAB11A, member RAS oncogene family	Homo sapiens	43-46
20890491-1	2010	Visible-light-derived O(2) production was yielded by conjugating water oxidation catalysis by [(OH(2))(terpy)Mn(mu-O)(2)Mn(terpy)(OH(2))](3+) as an oxygen evolving center model and photo-sensitization of [Ru(bpy)(3)](2+) as a photoexcitation center model at an interlayer of mica.	Water	65-70	MHC class I polypeptide-related sequence A	Homo sapiens	275-279
11474229-9	2001	Its expression in the kidney tubules, the major site of sulphation in the kidney, suggests that CDO in the kidney may play a role in both xenobiotic metabolism and sodium and water homeostasis.	Water	175-180	cysteine dioxygenase type 1	Rattus norvegicus	96-99
12683817-2	2003	Here we show that below 15 eV such low-energy electrons induce single (SSB) and double (DSB) strand breaks in plasmid DNA exclusively via formation and decay of molecular resonances involving DNA components (base, sugar, hydration water, etc.).	Water	231-236	small RNA binding exonuclease protection factor La	Homo sapiens	71-74
20890491-1	2010	Visible-light-derived O(2) production was yielded by conjugating water oxidation catalysis by [(OH(2))(terpy)Mn(mu-O)(2)Mn(terpy)(OH(2))](3+) as an oxygen evolving center model and photo-sensitization of [Ru(bpy)(3)](2+) as a photoexcitation center model at an interlayer of mica.	Water	96-102	MHC class I polypeptide-related sequence A	Homo sapiens	275-279
12728548-4	2003	H2O, all compounds with integer lithium content exhibit good lithium ionic conductivity in their high temperature cubic phases above T = 33 degrees C. Lithium doping of samples LiX.H2O and Li2(OH)X leads to a suppression of the phase transition into the noncubic phases and the good ionic conductivity is extended down to lower temperatures (T &lt; 0 degree C).	Water	0-3	ATP binding cassette subfamily A member 12	Homo sapiens	189-192
21054786-10	2010	In PRTFDC1, a water molecule at the position of the aspartic acid side chain position in HPRT might be responsible for the low activity observed by acting as a weak base.	Water	14-19	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	89-93
12676067-9	2003	CONCLUSION: AQP1 water channels facilitated osmotic fluid transport across the pleural surface.	Water	17-22	aquaporin 1	Mus musculus	12-16
11499660-4	2001	The objective of this study was to investigate the hypothesis that intraperitoneal ampho B increases and mercury chloride inhibits aquaporin-1-mediated water transport in a chronic peritoneal dialysis model in the rabbit.	Water	152-157	lens fiber major intrinsic protein	Oryctolagus cuniculus	131-140
11499660-19	2001	administration of HgCl2 with and without in vivo fixation, accompanied by a significant decrease in aquaporin-mediated water transport, estimated as the sieving of sodium (p &lt; 0.001).	Water	119-124	lens fiber major intrinsic protein	Oryctolagus cuniculus	100-109
11499660-24	2001	Aquaporin-mediated water transport could be inhibited and consequently ultrafiltration was reduced by i.p.	Water	19-24	lens fiber major intrinsic protein	Oryctolagus cuniculus	0-9
20671274-9	2010	Full-length Aqp0a is a functional water channel when expressed in Xenopus oocytes and in yeast, whereas Aqp0b was not.	Water	34-39	major intrinsic protein of lens fiber a	Danio rerio	12-17
11488450-3	2001	The water extract potently inhibited the production of AFM1 by cytochrome P450 (CYP)1A1/2 and slightly reduced AFBO formation by CYP1A1/2, CYP2B1, CYP2C11 and CYP3A1/2 in TCDD-treated rat liver microsomes.	Water	4-9	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	139-145
20671274-10	2010	However, the addition of an HA-tag at its N terminus converted Aqp0b to a water channel in Xenopus oocytes.	Water	74-79	major intrinsic protein of lens fiber b	Danio rerio	63-68
11488450-3	2001	The water extract potently inhibited the production of AFM1 by cytochrome P450 (CYP)1A1/2 and slightly reduced AFBO formation by CYP1A1/2, CYP2B1, CYP2C11 and CYP3A1/2 in TCDD-treated rat liver microsomes.	Water	4-9	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	159-167
12649393-8	2003	hUcn II dose dependently reduced the quantity and duration of responding for food and water at doses lower (0.01-1.0 micro g) than that forming a CTA (10 micro g).	Water	86-91	urocortin 2	Homo sapiens	0-7
20671274-11	2010	CONCLUSIONS: These results suggest that Aqp0a is the primary water channel of the lens and that Aqp0b, though possibly a secondary water channel, has an unidentified function in the lens.	Water	61-66	major intrinsic protein of lens fiber a	Danio rerio	40-45
20671274-11	2010	CONCLUSIONS: These results suggest that Aqp0a is the primary water channel of the lens and that Aqp0b, though possibly a secondary water channel, has an unidentified function in the lens.	Water	131-136	major intrinsic protein of lens fiber b	Danio rerio	96-101
20723907-0	2010	Water-soluble ZnO-Au nanocomposite-based probe for enhanced protein detection in a SPR biosensor system.	Water	0-5	sepiapterin reductase	Homo sapiens	83-86
12920893-8	2003	From the year 2010 to 2030, the gross ecological water demand would be consisted of two parts (the gross stand water amount between Daxihaizi and Alagan, and the water demand by increased vegetation of 18.67 x 10(4) hm2), and the total ecological water demand during the 20 years would be 139.00 x 10(8) m3.	Water	49-54	cholinergic receptor muscarinic 2	Homo sapiens	216-219
12615353-0	2003	Computer simulation of water in cytochrome c oxidase.	Water	23-28	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	32-52
12615353-1	2003	Statistical mechanics and molecular dynamics simulations have been carried out to study the distribution and dynamics of internal water molecules in bovine heart cytochrome c oxidase (CcO).	Water	130-135	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	162-182
12615353-1	2003	Statistical mechanics and molecular dynamics simulations have been carried out to study the distribution and dynamics of internal water molecules in bovine heart cytochrome c oxidase (CcO).	Water	130-135	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	184-187
12615353-2	2003	CcO is found to be capable of holding plenty of water, which in subunit I alone amounts to about 165 molecules.	Water	48-53	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-3
11283020-10	2001	The sensitivity of KGDH and SDH to H(2)O(2)-mediated inactivation and the reversible nature of inactivation suggest a potential role for H(2)O(2) in the regulation of KGDH and SDH.	Water	35-40	oxoglutarate dehydrogenase	Rattus norvegicus	19-23
11283020-10	2001	The sensitivity of KGDH and SDH to H(2)O(2)-mediated inactivation and the reversible nature of inactivation suggest a potential role for H(2)O(2) in the regulation of KGDH and SDH.	Water	35-40	oxoglutarate dehydrogenase	Rattus norvegicus	167-171
11376685-11	2001	In addition, administration of 4-nitroquinoline-1-oxide in drinking water for 50 weeks resulted in tongue tumors only in XPA-/- mice.	Water	68-73	xeroderma pigmentosum, complementation group A	Mus musculus	121-124
20800353-3	2010	Our sample of GNS(PF6) was developed for the removal of Pb(II) or Cd(II) ions from water, and the determined adsorption capacities are 406.6 mg/g (pH=5.1) for Pb(II) and 73.42 mg/g (pH=6.2) for Cd(II), which is much higher than that by our previous sample of GNS(C8P) and carbon nanotube.	Water	83-88	sperm associated antigen 17	Homo sapiens	18-21
11426712-7	2001	Because water is cotransported with glucose molecules by the SGLT protein, its high expression in neurocysticerci may contribute to the expansive growth of these larvae in subarachnoid and intraventricular sites.	Water	8-13	solute carrier family 5 member 11	Homo sapiens	61-65
12556366-2	2003	In this study, we investigated whether the abundance and subcellular localization of pendrin are regulated in response to experimental metabolic acidosis and alkalosis with maintained water and sodium intake.	Water	184-189	solute carrier family 26 member 4	Rattus norvegicus	85-92
21055716-5	2010	Furthermore, we show that the mutation has a dominant-negative effect on KLF1 transcriptional activity and unexpectedly abolishes the expression of the water channel AQP1 and the adhesion molecule CD44.	Water	152-157	Kruppel like factor 1	Homo sapiens	73-77
12899737-2	2003	Researchers are beginning to examine the role of the phase II UDP-glucuronosyltransferase (UGT) enzymes, which produce products that are more water-soluble, less toxic and more readily excreted than the parent compounds.	Water	142-147	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	62-89
12899737-2	2003	Researchers are beginning to examine the role of the phase II UDP-glucuronosyltransferase (UGT) enzymes, which produce products that are more water-soluble, less toxic and more readily excreted than the parent compounds.	Water	142-147	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	91-94
11426712-10	2001	Furthermore, high expression of this cotransporter was seen in the branches of the uterus, suggesting that SGLT-mediated absorption of glucose and water has an important functional role within the reproductive system of adult tapeworms.	Water	147-152	solute carrier family 5 member 11	Homo sapiens	107-111
21051640-3	2010	EF-Tu is in its active conformation, the switch I loop is ordered, and the catalytic histidine is coordinating the nucleophilic water in position for inline attack on the gamma-phosphate of GTP.	Water	128-133	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	0-5
12674220-0	2003	Enhanced food and water intake in renin transgenic rats.	Water	18-23	renin	Rattus norvegicus	34-39
20947810-8	2010	The decrease of MMP-9 in mice treated with SFN was associated with decreased levels of spinal cord water content and TNF-alpha.	Water	99-104	matrix metallopeptidase 9	Mus musculus	16-21
12573807-2	2003	Water deprivation significantly increased plasma renin activity (PRA), plasma Angiotensin II (AII), vasopressin (AVP), epinephrine, aldosterone and corticosterone concentrations but did not modify the plasma adrenocorticotropin hormone (ACTH) level.	Water	0-5	renin	Rattus norvegicus	49-54
12633305-1	2003	We present a surface x-ray diffraction study on the KDP-water interface in which the structure of both the crystalline and liquid part of the interface has been measured.	Water	56-61	WNK lysine deficient protein kinase 1	Homo sapiens	52-55
11415144-0	2001	Two-state protein model with water interactions: influence of temperature on the intrinsic viscosity of myoglobin.	Water	29-34	myoglobin	Physeter catodon	104-113
11358830-7	2001	Drinking water containing TPA caused a 25.8-fold induction of AP-1 activity in the skin, whereas gavage feeding with TPA caused a 34.2-fold induction of AP-1 in the skin.	Water	9-14	jun proto-oncogene	Mus musculus	62-66
20639120-9	2010	High doses of H(2)O(2) inhibit while low doses of H(2)O(2) activate mTORC1 both in TSC2(-/-) P53(-/-) and TSC2(+/+) P53(-/-) MEFs.	Water	14-19	CREB regulated transcription coactivator 1	Mus musculus	68-74
11350166-1	2001	Two-dimensional crystals of a membrane protein, the proton ATPase from plant plasma membranes, have been obtained by a new strategy based on the use of functionalized, fluorinated lipids spread at the air-water interface.	Water	205-210	dynein axonemal heavy chain 8	Homo sapiens	59-65
19731054-8	2010	Concentrations of all gamma -ray emitting radionuclides except 40K in water samples were below the detection limits.	Water	70-75	small nuclear ribonucleoprotein U5 subunit 40	Homo sapiens	63-66
11320486-9	2001	AQP7 is abundant in the brush border of proximal tubule cells and is likely to be involved in proximal tubule water reabsorption.	Water	110-115	aquaporin 7	Homo sapiens	0-4
12604204-8	2003	In the FDH.NAD(H) binary complex reported here, Glu67 is added to the coordination environment of the active site zinc and the distance between the water molecule and zinc is increased.	Water	148-153	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	7-10
12577045-0	2003	Lafutidine, a novel histamine H2-receptor antagonist, increases serum calcitonin gene-related peptide in rats after water immersion-restraint stress.	Water	116-121	calcitonin-related polypeptide alpha	Rattus norvegicus	70-101
19731054-9	2010	The 40K sediment-water distribution coefficients of the near-shore samples were higher than the off-shore samples.	Water	17-22	small nuclear ribonucleoprotein U5 subunit 40	Homo sapiens	4-7
20628405-3	2010	In this crossover study, on three separate occasions, 10 patients who were homozygous for the C282Y mutation in the HFE gene (and fully treated) consumed a vegetarian meal containing 13.9 mg iron with: 200 ml water; 200 ml water and 140 mg silybin (Legalon Forte); or 200 ml tea.	Water	209-214	homeostatic iron regulator	Homo sapiens	116-119
12531268-4	2003	In this study six nanofiltration membranes (NF70, NF255, NTR-7450, NTR-7410, Desal-5 and TFC-S) were evaluated in improving the quality of chemically pre-treated surface water in a pilot-scale process.	Water	170-175	neurotensin receptor 1	Homo sapiens	57-60
11323233-4	2001	Spreading properties and surface activity of (99m)Tc-labelled SP-B in an air/water interface coincided with those of unlabelled SP-B.	Water	77-82	surfactant protein B	Homo sapiens	62-66
11323233-11	2001	RESULTS: The hydrophobic protein SP-B was labelled with [(99m)Tc(CO)(3)(H2O)(3)](+).	Water	72-75	surfactant protein B	Homo sapiens	33-37
11323233-15	2001	Spreading properties of (99m)Tc-labelled SP-B in an air/water interface coincided with those of unlabelled SP-B.	Water	56-61	surfactant protein B	Homo sapiens	41-45
11323233-18	2001	CONCLUSIONS: Direct and specific (99m)Tc-labelling of the hydrophobic surfactant protein B was achieved using the [(99m)Tc(CO)(3)(H2O)(3)](+) precursor.	Water	130-133	surfactant protein B	Homo sapiens	70-90
20628405-3	2010	In this crossover study, on three separate occasions, 10 patients who were homozygous for the C282Y mutation in the HFE gene (and fully treated) consumed a vegetarian meal containing 13.9 mg iron with: 200 ml water; 200 ml water and 140 mg silybin (Legalon Forte); or 200 ml tea.	Water	223-228	homeostatic iron regulator	Homo sapiens	116-119
20510528-3	2010	The fat reduction in slow fermented sausages produced an increase in the pH decline during the first stage of the process that was favoured by the higher water content of the low fat sausages.	Water	154-159	FAT atypical cadherin 1	Homo sapiens	4-7
11456923-1	2001	Molecular dynamics (MD) simulations and free energy component analysis have been performed to evaluate the molecular origins of the 5.5 kcal/mol destabilization of the complex formed between the N-terminal RNP domain of U1A and stem loop 2 of U1 snRNA upon mutation of a conserved aromatic residue, Phe56, to Ala. MD simulations, including counterions and water, have been carried out on the wild type and Phe56Ala peptide-stem loop 2 RNA complexes, the free wild type and Phe56Ala peptides, and the free stem loop 2 RNA.	Water	356-361	RNA, U1 small nuclear 1	Homo sapiens	243-251
12517123-0	2003	Aerobic oxidation of methyl p-tolyl sulfide catalyzed by a remarkably labile heteroscorpionate RuII-aqua complex, fac-[RuII(H2O)(dpp)(tppm)]2+.	Water	124-127	dentin sialophosphoprotein	Homo sapiens	129-132
12517123-3	2003	The remarkably short distance between O(40) of H2O and H(45a) of dpp confirms the heteroscorpionate ligand effect of dpp on H2O.	Water	47-50	dentin sialophosphoprotein	Homo sapiens	117-120
12517123-3	2003	The remarkably short distance between O(40) of H2O and H(45a) of dpp confirms the heteroscorpionate ligand effect of dpp on H2O.	Water	124-127	dentin sialophosphoprotein	Homo sapiens	65-68
12517123-3	2003	The remarkably short distance between O(40) of H2O and H(45a) of dpp confirms the heteroscorpionate ligand effect of dpp on H2O.	Water	124-127	dentin sialophosphoprotein	Homo sapiens	117-120
20483026-13	2010	MMP-9 knockdown mice also displayed less uptake of Evans blue and reduced brain water content compared with control siRNA-treated group.	Water	80-85	matrix metallopeptidase 9	Mus musculus	0-5
12507761-8	2003	The data suggest that AQP1 contributes to water transport across the apical membrane of the choroid plexus epithelium during CSF secretion.	Water	42-47	aquaporin 1	Rattus norvegicus	22-26
11248203-3	2001	We have then evaluated free energy (Delta F(not equal)), enthalpy (Delta H(not equal)) and entropy (Delta S(not equal)) of activation for water permeation across membranes, such as Arbacia eggs, Xenopus oocytes with or without aquaporin water channels, mammalian erythrocytes, aquaporin proteoliposomes, liposomes and collodion membrane.	Water	138-143	aquaporin	Xenopus laevis	227-236
20416860-6	2010	Clinically, the development of non-peptide analogs of the apelin receptor could provide new therapeutic tools potentially useful for the treatment of heart failure, states of water and/or electrolyte retention, and type 2 diabetes mellitus.	Water	175-180	apelin	Mus musculus	58-64
11248203-3	2001	We have then evaluated free energy (Delta F(not equal)), enthalpy (Delta H(not equal)) and entropy (Delta S(not equal)) of activation for water permeation across membranes, such as Arbacia eggs, Xenopus oocytes with or without aquaporin water channels, mammalian erythrocytes, aquaporin proteoliposomes, liposomes and collodion membrane.	Water	138-143	aquaporin	Xenopus laevis	277-286
11248203-7	2001	Largely negative Delta S(not equal) and low Delta H(not equal) values for aquaporin water channels, aquaporin proteoliposomes and porous collodion membrane could be explained by the immobilization of permeating water molecules in the membrane, i.e., the partial loss of rotational and/or translational freedoms of water molecules in water channels.	Water	84-89	aquaporin	Xenopus laevis	74-83
11248203-7	2001	Largely negative Delta S(not equal) and low Delta H(not equal) values for aquaporin water channels, aquaporin proteoliposomes and porous collodion membrane could be explained by the immobilization of permeating water molecules in the membrane, i.e., the partial loss of rotational and/or translational freedoms of water molecules in water channels.	Water	211-216	aquaporin	Xenopus laevis	74-83
11248203-7	2001	Largely negative Delta S(not equal) and low Delta H(not equal) values for aquaporin water channels, aquaporin proteoliposomes and porous collodion membrane could be explained by the immobilization of permeating water molecules in the membrane, i.e., the partial loss of rotational and/or translational freedoms of water molecules in water channels.	Water	211-216	aquaporin	Xenopus laevis	100-109
11248203-7	2001	Largely negative Delta S(not equal) and low Delta H(not equal) values for aquaporin water channels, aquaporin proteoliposomes and porous collodion membrane could be explained by the immobilization of permeating water molecules in the membrane, i.e., the partial loss of rotational and/or translational freedoms of water molecules in water channels.	Water	211-216	aquaporin	Xenopus laevis	74-83
11248203-7	2001	Largely negative Delta S(not equal) and low Delta H(not equal) values for aquaporin water channels, aquaporin proteoliposomes and porous collodion membrane could be explained by the immobilization of permeating water molecules in the membrane, i.e., the partial loss of rotational and/or translational freedoms of water molecules in water channels.	Water	211-216	aquaporin	Xenopus laevis	100-109
11248209-1	2001	Pulmonary surfactant protein SP-B is known to facilitate adsorption and spreading of surfactant components across the air/water interface.	Water	122-127	surfactant protein B	Homo sapiens	29-33
12473451-10	2003	The higher quality X-ray data for the closed ATP complex (2.2A) provide new structural details likely related to catalysis, including an extension of the KMSKS loop that engages the second lysine and serine residues, K195 and S196, with the alpha and gamma-phosphates; interactions of the K111 side-chain with the gamma-phosphate; and a water molecule bridging the consensus sequence residue T15 to the beta-phosphate.	Water	337-342	ATPase phospholipid transporting 8A2	Homo sapiens	45-48
12388241-0	2003	Role of AT2 receptor in the brain in regulation of blood pressure and water intake.	Water	70-75	angiotensin II receptor, type 2	Mus musculus	8-20
20534382-11	2010	In conclusion, measurement of the noxious heat threshold with the increasing-temperature water bath is suitable to sensitively detect the effects of TRPV1 receptor antagonists in thermal hyperalgesia models.	Water	89-94	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	149-154
12646377-4	2003	Interpretation of the thermodynamic parameters in buffered solution of water, 30% glycerol and D(2)O leads to the conclusion that the highly specific binding of CsA to hCyp18 is mainly mediated through hydrogen bonding and to a lesser degree through hydrophobic interaction.	Water	71-76	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	161-164
11312693-2	2001	The water-soluble substrates, which are derived from fluorescein, are not fluorescent until cleaved by the enzyme, and provide a convenient means to continuously monitor PI-PLC activity.	Water	4-9	phospholipase C beta 1	Homo sapiens	170-176
11285922-7	2001	Enhanced water retention capacity improved the cohesion and handling property of harvested sod.	Water	9-14	Superoxide dismutase 1	Drosophila melanogaster	91-94
12521113-8	2003	The organic carbon normalised distribution coefficient (K(oc)) also increased with the compounds" octanol/water partition coefficient (K(ow)), confirming the potential applicability of the linear free energy relationships in the modelling and prediction of PAH behaviour in marine environments.	Water	106-111	phenylalanine hydroxylase	Homo sapiens	257-260
20529870-6	2010	Overexpression of constitutive active Rac1 (V12) revealed that H(2)O(2) was derived from the mitochondria.	Water	63-68	Rac family small GTPase 1	Mus musculus	38-42
12535340-2	2003	The erd1 gene has been shown to be upregulated in response to both water stress and etiolation.	Water	67-72	Clp ATPase	Arabidopsis thaliana	4-8
11386160-1	2001	The 5-HT1A agonist 8-OH-DPAT was shown to diminish the water and 1.8% NaCl solution consumption, whereas its antagonist pMPPI--to enhance the water intake in rats.	Water	55-60	5-hydroxytryptamine receptor 1A	Rattus norvegicus	4-10
11386160-1	2001	The 5-HT1A agonist 8-OH-DPAT was shown to diminish the water and 1.8% NaCl solution consumption, whereas its antagonist pMPPI--to enhance the water intake in rats.	Water	142-147	5-hydroxytryptamine receptor 1A	Rattus norvegicus	4-10
20698073-4	2004	Most contrast agents affect the T1 and T2 relaxation of the surrounding nuclei, mainly the protons of water.	Water	102-107	interleukin 1 receptor like 1	Homo sapiens	32-34
11250198-8	2001	Interaction with the degenerate position is mediated by a purine-specific hydrogen bond to N7, ensuring specificity, and water-mediated H bonding to the purine N6/O6 and pyrimidine N4/O4, allowing degeneracy.	Water	121-126	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	181-186
12493831-11	2003	In this ligand-free OXA-1 structure, no water molecule is seen in this site, so the water molecule must enter after formation of the acyl-Ser 67 intermediate.	Water	84-89	beta-lactamase OXA-1 precursor	Escherichia coli	20-25
20698073-18	2004	The other method is indirect MRI measurement based on the enhancement of T1p relaxation of protons in water by (17)O. CMRO2 and CBF can be measured with (17)O NMR spectroscopy and MRI after inhalation of (17)O2.	Water	102-107	interleukin 1 receptor like 1	Homo sapiens	73-76
12490222-3	2002	YMP also increased the myeloperoxidase activity and the production of H(2)O(2), O(2)(-), nitric oxide (NO) and tumor necrosis factor (TNF-alpha).	Water	70-75	epithelial membrane protein 3	Mus musculus	0-3
20698074-4	2004	Most contrast agents affect the T1 and T2 relaxation of the surrounding nuclei, mainly the protons of water.	Water	102-107	interleukin 1 receptor like 1	Homo sapiens	32-34
20698074-18	2004	The other method is indirect MRI measurement based on the enhancement of T1p relaxation of protons in water by (17)O. CMRO2 and CBF can be measured with (17)O NMR spectroscopy and MRI after inhalation of (17)O2.	Water	102-107	interleukin 1 receptor like 1	Homo sapiens	73-76
12572868-6	2002	RESULTS: The analysis of downregulated genes in the DSS mice following PPARgamma administration revealed several functional gene clusters with altered expression: (1) oncogene families such as GRO1 oncogenes, (2) inflammatory mediator-related genes such as the interferon-gamma gene, (3) water electrolyte-associated genes, and (4) others.	Water	288-293	peroxisome proliferator activated receptor gamma	Mus musculus	71-80
20153100-3	2010	In vivo, hIAPP aggregation may start and proceed at the water-cell membrane interface and anionic lipid membranes strongly enhance the process of hIAPP fibrillization which is causally linked to membrane disintegration and cell degeneration.	Water	56-61	islet amyloid polypeptide	Homo sapiens	9-14
12472251-18	2002	This study demonstrated that low-dose application of TGFbeta1 and EGF significantly inhibited not only the increased water content and cross-sectional area, but also the decreased tensile strength caused by the freeze-thaw treatment, while a high dose of TGF-beta1 and EGF does not have the same beneficial effects.	Water	117-122	pro-epidermal growth factor	Oryctolagus cuniculus	66-69
18357034-4	2001	A 20-gauge cannula with a miniature CaF2 window shielded the waveguide from water.	Water	76-81	CCR4-NOT transcription complex subunit 8	Homo sapiens	36-40
20153100-11	2010	Finally, our studies show that once hIAPP is fibrillized at the water-lipid membrane interface with fibrils being attached to the lipid membrane, it cannot be disaggregated by all above peptides.	Water	64-69	islet amyloid polypeptide	Homo sapiens	36-41
11235674-3	2001	We have investigated the ability of tamoxifen to scavenge, in vitro, *OH and (or) HO2* free radicals that are produced by water radiolysis.	Water	122-127	heme oxygenase 2	Homo sapiens	82-85
20621491-1	2010	The peptide hormone ghrelin, which is the natural ligand of the membrane-bound growth hormone secretagogue receptor (GHS-R), regulates overall body and cell growth, energy homeostasis, carbohydrate, protein and lipid metabolism and water electrolyte balance.	Water	232-237	growth hormone secretagogue receptor	Homo sapiens	79-115
12419412-9	2002	It is concluded that central 5-HT(3) receptor activation exerts a specific inhibitory effect on water intake.	Water	96-101	5-hydroxytryptamine receptor 3A	Rattus norvegicus	29-45
20621491-1	2010	The peptide hormone ghrelin, which is the natural ligand of the membrane-bound growth hormone secretagogue receptor (GHS-R), regulates overall body and cell growth, energy homeostasis, carbohydrate, protein and lipid metabolism and water electrolyte balance.	Water	232-237	growth hormone secretagogue receptor	Homo sapiens	117-122
11802951-1	2001	OBJECTIVE: To explore the effects of aquaporins (AQP) 1, 4 on water transport between airspace and pulmonary capillary and high pressure pulmonary edema.	Water	62-67	aquaporin 1	Rattus norvegicus	37-55
11802951-3	2001	METHODS: The effects of AQP1, 4 on water transport between airspace and pulmonary capillary and high pressure pulmonary edema were studied by surface fluorescence methods and gravimetric method respectively, AFC and AFC in airspace with different pH were measured by isotope method.	Water	35-40	aquaporin 1	Rattus norvegicus	24-28
20931875-9	2010	The results of Canonical Correspondence Analysis suggested that the abundance of 558 bp T-RF was negatively correlated with NH4(+)-N, NO3(-)-N, TN, TP and TOC, but positively correlated with TOC/TN and the water depth; the abundance of 64.5, 164, 509, and 543 bp T-RFs were positively correlated with NH4(+)-N, NO3(-)-N, TN, TOC, TOC/TN and the water depth.	Water	206-211	interleukin 5	Homo sapiens	88-92
11802951-4	2001	RESULTS: AQP1 knockout inhibited water transport through pulmonary capillary and also reduced high pressure pulmonary edema.	Water	33-38	aquaporin 1	Rattus norvegicus	9-13
11802951-8	2001	CONCLUSIONS: AQP1 knockout significantly reduced water transport through alveolar capillary, and also reduced high pulmonary edema slightly.	Water	49-54	aquaporin 1	Rattus norvegicus	13-17
12403589-1	2002	We previously reported that the nuclear magnetic resonance (NMR) 14N spin-lattice relaxation times (T1) of CH3CN in CH3CN-H2O mixtures directly correlate with the solution viscosity when scaled for temperature (eta/T) in this common chromatographic mobile phase system."	Water	122-125	endothelin receptor type A	Homo sapiens	211-214
12413450-6	2002	Unfortunately, isothermal titration calorimetry (ITC) experiments indicated that a more water-soluble analog bound to the 47/23-mer oligonucleotide helicase substrate with low micromolar affinity as did the substituted quinazolinamine.	Water	88-93	helicase for meiosis 1	Homo sapiens	148-156
20931875-9	2010	The results of Canonical Correspondence Analysis suggested that the abundance of 558 bp T-RF was negatively correlated with NH4(+)-N, NO3(-)-N, TN, TP and TOC, but positively correlated with TOC/TN and the water depth; the abundance of 64.5, 164, 509, and 543 bp T-RFs were positively correlated with NH4(+)-N, NO3(-)-N, TN, TOC, TOC/TN and the water depth.	Water	345-350	interleukin 5	Homo sapiens	88-92
20526520-0	2010	Water adsorption in hydrophobic MOF channels.	Water	0-5	lysine acetyltransferase 8	Homo sapiens	32-35
12271491-1	2002	Aquaporin 1 (AQP1; also known as CHIP, a channel-forming integral membrane protein of 28 kDa) is the first protein to be shown to function as a water channel and has been recently shown to be present in the rat retina.	Water	144-149	aquaporin 1	Rattus norvegicus	0-11
12271491-1	2002	Aquaporin 1 (AQP1; also known as CHIP, a channel-forming integral membrane protein of 28 kDa) is the first protein to be shown to function as a water channel and has been recently shown to be present in the rat retina.	Water	144-149	aquaporin 1	Rattus norvegicus	13-17
20526520-3	2010	Moreover, we study the influence of functionalisation of the MOF organic linkers on the hydrophobicity of the material and the nature of the adsorption transition, and explain it in terms of the liquid-vapour phase diagram of water in this family of materials.	Water	226-231	lysine acetyltransferase 8	Homo sapiens	61-64
20501650-9	2010	Moreover, 1-oleoyl-2-acetyl-sn-glycerol effect on TRPC6 was significantly greater in the presence of H(2)O(2).	Water	101-106	transient receptor potential cation channel subfamily C member 6	Homo sapiens	50-55
12356727-1	2002	In the principal cell of the renal collecting duct, vasopressin regulates the expression of a gene network responsible for sodium and water reabsorption through the regulation of the water channel and the epithelial sodium channel (ENaC).	Water	134-139	arginine vasopressin S homeolog	Xenopus laevis	52-63
12356727-1	2002	In the principal cell of the renal collecting duct, vasopressin regulates the expression of a gene network responsible for sodium and water reabsorption through the regulation of the water channel and the epithelial sodium channel (ENaC).	Water	183-188	arginine vasopressin S homeolog	Xenopus laevis	52-63
20164464-15	2010	These data show that p38alpha MAPK-MSK1/2 is involved in the control of IL-17 synthesis by CD4(+) T cells and that inhibition of p38alpha MAPK in vitro suppresses IL-17 synthesis but that inhibition of this kinase in vivo did not protect from EAU.	Water	243-246	mitogen-activated protein kinase 14	Mus musculus	21-29
12395977-5	2002	RESULTS: Administration of CsA with grapefruit juice compared with water significantly increased the area under the whole blood concentration versus time curve in the interval from 0-12 hours (AUC(0-12)) of CsA, by an average of 25 +/- 19% (p = 0.002).	Water	67-72	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	207-210
12395977-11	2002	In addition, administration of CsA with grapefruit juice compared with water induced a moderate, but significant increase in systemic exposure of CsA in renal transplant recipients.	Water	71-76	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	146-149
20164464-15	2010	These data show that p38alpha MAPK-MSK1/2 is involved in the control of IL-17 synthesis by CD4(+) T cells and that inhibition of p38alpha MAPK in vitro suppresses IL-17 synthesis but that inhibition of this kinase in vivo did not protect from EAU.	Water	243-246	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	35-39
12406605-7	2002	Drinking water samples spiked with triazines were extracted using RP-C18 polar plus cartridges, and the extract could be then dansylated as a total.	Water	9-14	RNA polymerase II, I and III subunit H	Homo sapiens	66-72
20164464-15	2010	These data show that p38alpha MAPK-MSK1/2 is involved in the control of IL-17 synthesis by CD4(+) T cells and that inhibition of p38alpha MAPK in vitro suppresses IL-17 synthesis but that inhibition of this kinase in vivo did not protect from EAU.	Water	243-246	mitogen-activated protein kinase 14	Mus musculus	129-137
20102424-11	2010	CONCLUSIONS: Cov-IMS/ATP is a robust, in-field detection method for determining water quality of both fresh and marine water systems as well as differential loading of FIB from two converging channels.	Water	80-85	ATPase	Escherichia coli	13-24
20102424-11	2010	CONCLUSIONS: Cov-IMS/ATP is a robust, in-field detection method for determining water quality of both fresh and marine water systems as well as differential loading of FIB from two converging channels.	Water	119-124	ATPase	Escherichia coli	13-24
20579340-6	2010	RESULTS: In the present study, SSF was run successfully with 10% and 14% water-insoluble solids (WIS) in batch and fed-batch mode.	Water	73-78	peter pan homolog	Homo sapiens	31-34
20496117-7	2010	Water-mediated interactions between Asn267 and Asn39 of hPNMT and the amide or amine group of three potent inhibitors were additional important features for hPNMT activity.	Water	0-5	phenylethanolamine N-methyltransferase	Homo sapiens	56-61
20496117-7	2010	Water-mediated interactions between Asn267 and Asn39 of hPNMT and the amide or amine group of three potent inhibitors were additional important features for hPNMT activity.	Water	0-5	phenylethanolamine N-methyltransferase	Homo sapiens	157-162
22716472-5	2010	Polycarbophil AA1 showed highest water uptake and swelling capacity.	Water	33-38	AA1	Homo sapiens	14-17
20382894-4	2010	In addition, ectopic cell expansion was observed around both water- and OS-treated wounds in mETR1asLOX3 leaves but not in mETR1, asLOX3, or wild-type leaves.	Water	61-66	CUGBP, Elav-like family member 3	Mus musculus	93-98
20866447-4	2010	The Flory exponent nu(Phi) decreases from nu(0) 0.48 in water down to 0.3 with macromolecular crowding.	Water	56-61	glucose-6-phosphate isomerase	Homo sapiens	22-25
20588944-2	2010	The FDTD results show that in a uniform medium (water), the full width at half maximum (FWHM) (transverse resolution) of radially polarized near-field CARS (RP-CARS) radiation is approximately 7.7% narrower than that of linearly polarized near-field CARS (LP-CARS) imaging, whereas the depth of focus (DOF) of RP-CARS radiation is 6.5% longer than LP-CARS.	Water	48-53	cysteinyl-tRNA synthetase 1	Homo sapiens	151-155
20588944-2	2010	The FDTD results show that in a uniform medium (water), the full width at half maximum (FWHM) (transverse resolution) of radially polarized near-field CARS (RP-CARS) radiation is approximately 7.7% narrower than that of linearly polarized near-field CARS (LP-CARS) imaging, whereas the depth of focus (DOF) of RP-CARS radiation is 6.5% longer than LP-CARS.	Water	48-53	cysteinyl-tRNA synthetase 1	Homo sapiens	160-164
20588944-2	2010	The FDTD results show that in a uniform medium (water), the full width at half maximum (FWHM) (transverse resolution) of radially polarized near-field CARS (RP-CARS) radiation is approximately 7.7% narrower than that of linearly polarized near-field CARS (LP-CARS) imaging, whereas the depth of focus (DOF) of RP-CARS radiation is 6.5% longer than LP-CARS.	Water	48-53	cysteinyl-tRNA synthetase 1	Homo sapiens	160-164
20588944-2	2010	The FDTD results show that in a uniform medium (water), the full width at half maximum (FWHM) (transverse resolution) of radially polarized near-field CARS (RP-CARS) radiation is approximately 7.7% narrower than that of linearly polarized near-field CARS (LP-CARS) imaging, whereas the depth of focus (DOF) of RP-CARS radiation is 6.5% longer than LP-CARS.	Water	48-53	cysteinyl-tRNA synthetase 1	Homo sapiens	256-263
20588944-2	2010	The FDTD results show that in a uniform medium (water), the full width at half maximum (FWHM) (transverse resolution) of radially polarized near-field CARS (RP-CARS) radiation is approximately 7.7% narrower than that of linearly polarized near-field CARS (LP-CARS) imaging, whereas the depth of focus (DOF) of RP-CARS radiation is 6.5% longer than LP-CARS.	Water	48-53	cysteinyl-tRNA synthetase 1	Homo sapiens	160-164
20588944-2	2010	The FDTD results show that in a uniform medium (water), the full width at half maximum (FWHM) (transverse resolution) of radially polarized near-field CARS (RP-CARS) radiation is approximately 7.7% narrower than that of linearly polarized near-field CARS (LP-CARS) imaging, whereas the depth of focus (DOF) of RP-CARS radiation is 6.5% longer than LP-CARS.	Water	48-53	cysteinyl-tRNA synthetase 1	Homo sapiens	348-355
20423346-0	2010	A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse.	Water	77-82	glutamate receptor, metabotropic 7	Mus musculus	21-54
20303273-6	2010	As for pain sensitivity and its relationship with TCI, we found a low negative correlation between cold water stimulation, disorderliness (NS4) and novelty seeking (NS) in males, whereas in females we found a low positive correlation between cold water stimulation, self-acceptance (SD4) and pure-hearted principles (C5), as well as pressure stimulation and SD4.	Water	104-109	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	139-142
19731985-3	2010	Aquaporin-1 (AQP-1), a water channel found in the brain, can function as a transporter for CO2 across the cellular membrane.	Water	23-28	aquaporin 1	Rattus norvegicus	0-11
19731985-3	2010	Aquaporin-1 (AQP-1), a water channel found in the brain, can function as a transporter for CO2 across the cellular membrane.	Water	23-28	aquaporin 1	Rattus norvegicus	13-18
20298483-8	2010	Expression of BAX inhibitor-1 (AtBI1) was increased in response to water stress, and atbi1-1 displayed accelerated cell death, indicating that AtBI1 and the endoplasmic reticulum (ER) stress response pathway both modulate water stress-induced PCD.	Water	67-72	BAX inhibitor 1	Arabidopsis thaliana	14-29
20298483-8	2010	Expression of BAX inhibitor-1 (AtBI1) was increased in response to water stress, and atbi1-1 displayed accelerated cell death, indicating that AtBI1 and the endoplasmic reticulum (ER) stress response pathway both modulate water stress-induced PCD.	Water	67-72	BAX inhibitor 1	Arabidopsis thaliana	31-36
20298483-8	2010	Expression of BAX inhibitor-1 (AtBI1) was increased in response to water stress, and atbi1-1 displayed accelerated cell death, indicating that AtBI1 and the endoplasmic reticulum (ER) stress response pathway both modulate water stress-induced PCD.	Water	222-227	BAX inhibitor 1	Arabidopsis thaliana	14-29
20298483-8	2010	Expression of BAX inhibitor-1 (AtBI1) was increased in response to water stress, and atbi1-1 displayed accelerated cell death, indicating that AtBI1 and the endoplasmic reticulum (ER) stress response pathway both modulate water stress-induced PCD.	Water	222-227	BAX inhibitor 1	Arabidopsis thaliana	85-90
20298483-8	2010	Expression of BAX inhibitor-1 (AtBI1) was increased in response to water stress, and atbi1-1 displayed accelerated cell death, indicating that AtBI1 and the endoplasmic reticulum (ER) stress response pathway both modulate water stress-induced PCD.	Water	222-227	BAX inhibitor 1	Arabidopsis thaliana	143-148
20379517-1	2010	The volumetric properties of human islet amyloid polypeptide (hIAPP) in water were studied in a wide temperature range by computer simulations.	Water	72-77	islet amyloid polypeptide	Homo sapiens	62-67
20379517-2	2010	The intrinsic density rho(p) and the intrinsic thermal expansion coefficient alpha(p) of hIAPP were evaluated by taking into account the difference between the volumetric properties of hydration and bulk water.	Water	204-209	islet amyloid polypeptide	Homo sapiens	89-94
20441253-1	2010	We applied the self-consistent polarization density functional theory (SCP-DFT) to water.	Water	83-88	urocortin 3	Homo sapiens	71-74
20441253-5	2010	For liquid water, both BLYP and SCP-DFT predict radial distribution functions that are similar and overstructured compared to experiment.	Water	11-16	urocortin 3	Homo sapiens	32-35
20409474-1	2010	The hydrophobic surfactant proteins SP-B and SP-C promote rapid adsorption of pulmonary surfactant to an air/water interface.	Water	109-114	surfactant protein B	Homo sapiens	36-40
20156623-3	2010	Water sorption isotherms have a standard type II sigmoid shape obeying the BET model in the relative pressure range 0.05-0.35.	Water	0-5	delta/notch like EGF repeat containing	Homo sapiens	75-78
20156623-4	2010	A modified BET model was used to estimate the water adsorbed on primary and secondary sites, respectively.	Water	46-51	delta/notch like EGF repeat containing	Homo sapiens	11-14
20183853-3	2010	Four kinase systems (Src family, Abl/c-Kit, Syk/ZAP-70, and CDK2/4) were investigated, and differences in predicted water molecule locations and energetics were able to explain the experimentally observed binding selectivity profiles.	Water	116-121	cyclin dependent kinase 2	Homo sapiens	60-66
20177708-5	2010	In the AQP1-immunoreactive microvessels, the AQP1 probably facilitates water movement between blood and interstitium as one component of the normal fluxes that occur in these specialised sensory and secretory areas.	Water	71-76	aquaporin 1	Rattus norvegicus	7-11
11510275-0	2001	Renin-angiotensin system plays an important role in the regulation of water transport in the peritoneum.	Water	70-75	renin	Rattus norvegicus	0-5
11510275-10	2001	Our results suggest that the renin-angiotensin system plays an important role in the regulation of water transport in the peritoneum.	Water	99-104	renin	Rattus norvegicus	29-34
20177708-5	2010	In the AQP1-immunoreactive microvessels, the AQP1 probably facilitates water movement between blood and interstitium as one component of the normal fluxes that occur in these specialised sensory and secretory areas.	Water	71-76	aquaporin 1	Rattus norvegicus	45-49
20492274-6	2010	A water extract of mulberry tea sample was subjected to HPAEC-PAD in a CarboPac MA1 column with a sodium hydroxide gradient.	Water	2-7	PNMA family member 1	Homo sapiens	80-83
11121384-1	2001	Immunocytochemistry showed expression of aquaporin-1 (AQP1) water channels at sites involved in dietary fat processing, including intrahepatic cholangiocytes, gallbladder, pancreatic microvascular endothelium, and intestinal lacteals.	Water	60-65	aquaporin 1	Mus musculus	41-52
11121384-1	2001	Immunocytochemistry showed expression of aquaporin-1 (AQP1) water channels at sites involved in dietary fat processing, including intrahepatic cholangiocytes, gallbladder, pancreatic microvascular endothelium, and intestinal lacteals.	Water	60-65	aquaporin 1	Mus musculus	54-58
12513744-2	2002	This automated colorimetric assay is based on the characteristic of viable and metabolically active leukemic cells to cleave MTS/pms into a water-soluble product whose optical density is determined at 492 nm by an automated microtiter-plate reader photometer.	Water	140-145	MLRL	Homo sapiens	125-128
20423836-4	2010	RESULTS: In the burn model group, the water content in the intestinal tissue increased at 4 h after the injury, reaching the peak level at 48 h; AQP-1 expression decreased at 8 h after severe burn and reached the lowest level at 48 h. AQP-1 expression level showed a significant inverse correlation to the water content (P&lt;0.01).	Water	306-311	aquaporin 1	Rattus norvegicus	145-150
12513744-5	2002	Compared with MTT and INT assays, the reduced product of MTS/pms is water-soluble.	Water	68-73	MLRL	Homo sapiens	57-60
11321891-1	2001	In the present study we ascertained whether cagA positive and negative H. pylori strains release water soluble products that can influence the production of gastric mucosal cytokines and endocrine (gastrin) or exocrine (pepsinogen C) secretion in 23 H. pylori positive and 19 H. pylori negative patients.	Water	97-102	S100 calcium binding protein A8	Homo sapiens	44-48
11321891-5	2001	Water extracts from cagA positive, (2.)	Water	0-5	S100 calcium binding protein A8	Homo sapiens	20-24
11321891-6	2001	Water extracts from cagA negative strains or (3.)	Water	0-5	S100 calcium binding protein A8	Homo sapiens	20-24
11321891-10	2001	Water extracts from cagA positive strains enhanced the release of PGC in mucosal biopsy supernatants (p &lt; 0.05) when patients were considered overall and the release of TNF alpha (p &lt; 0.05) when only patients with duodenal ulcer were considered.	Water	0-5	S100 calcium binding protein A8	Homo sapiens	20-24
11321891-11	2001	Water extracts from cagA negative strains stimulated gastrin secretion (p &lt; 0.05).	Water	0-5	S100 calcium binding protein A8	Homo sapiens	20-24
12235484-9	2002	Finally, addition of syncollin to liposomes rendered them permeable to the water-soluble fluorescent probe 5(6)-carboxyfluorescein.	Water	75-80	syncollin	Homo sapiens	21-30
11321891-13	2001	In conclusion, pepsinogen C and TNF alpha can be induced by cagA positive water extracts and may contribute to damage the gastric and duodenal mucosa.	Water	74-79	S100 calcium binding protein A8	Homo sapiens	60-64
20423836-4	2010	RESULTS: In the burn model group, the water content in the intestinal tissue increased at 4 h after the injury, reaching the peak level at 48 h; AQP-1 expression decreased at 8 h after severe burn and reached the lowest level at 48 h. AQP-1 expression level showed a significant inverse correlation to the water content (P&lt;0.01).	Water	306-311	aquaporin 1	Rattus norvegicus	235-240
12185013-10	2002	These results suggest that colon water absorption is mostly transcellular and mediated by water channels like AQP-1.	Water	33-38	aquaporin-1	Octodon degus	110-115
20366487-0	2010	Exceptionally strong hydrogen bonds affect the surface energy of colloidal nanocrystals: methylamine and water adsorption on PbS.	Water	105-110	cholinergic receptor muscarinic 3	Homo sapiens	125-128
12185013-13	2002	The roles of AQP-8 and AQP-3 in water absorption remain to be established.	Water	32-37	aquaporin-8	Octodon degus	13-18
12193408-9	2002	As a solution, we injected zebrafish embryos with mRNA for the aquaporin-3 water channel protein and demonstrated increased membrane permeability to water and to a cryoprotectant.	Water	75-80	aquaporin 3a	Danio rerio	63-74
11479694-1	2001	Cyfra 21-1 is a tumor marker based on the determination of water-soluble cytokeratin 19 which is secreted by normal or malignantly transformed epithelial cells.	Water	59-64	keratin 19	Homo sapiens	73-87
20014788-1	2010	A large ionic water cluster H(H(2)O)(28)(+), consisting of a water shell (H(2)O)(26) and an encaged species H(H(2)O)(2)(+) as a center core, was trapped in the well-modulated cavity of a porous metal-organic framework (MOF) {[Co(4)(dpdo)(12)(PMo(12)O(40))(3)](-)}(infinity) and structurally characterized.	Water	14-19	lysine acetyltransferase 8	Homo sapiens	194-223
18968149-3	2000	Then, some examples were studied showing the necessity to take into account the formation constant of CaF(2): the supersaturation of solutions, the validity of results from the fluoride selective electrode, the difference between released fluoride in distilled water and in artificial saliva in restorative dentistry, the fluoride concentration in hard waters and its health consequences.	Water	261-266	CCR4-NOT transcription complex subunit 8	Homo sapiens	102-108
12219172-2	2002	AT1 receptor activation leads to cell growth, vascular contraction, inflammatory responses and salt and water retention, whereas AT2 receptors induce apoptosis, vasodilation and natriuresis.	Water	104-109	angiotensin II receptor type 1	Homo sapiens	0-3
12219173-5	2002	These results suggest the angiotensinergic effect of the MSA on the AT1 and AT2 receptors of the PVN in terms of water and sodium homeostasis and MAP modulation.	Water	113-118	angiotensin II receptor, type 1a	Rattus norvegicus	68-71
12219173-5	2002	These results suggest the angiotensinergic effect of the MSA on the AT1 and AT2 receptors of the PVN in terms of water and sodium homeostasis and MAP modulation.	Water	113-118	angiotensin II receptor, type 2	Rattus norvegicus	76-79
11106604-0	2000	Residence times of water molecules in the hydration sites of myoglobin.	Water	19-24	myoglobin	Physeter catodon	61-70
20178314-7	2010	These results imply that (a) upon docking charged inhibitors into the active site of kinases such as FAK, the presence of a limited number of structured water molecules is critical to enable meaningful relative energy balances and (b) accounting for an explicit polarization contribution within DeltaE is indispensable.	Water	153-158	protein tyrosine kinase 2	Homo sapiens	101-104
19904957-1	2010	Water sorption isotherms of proteins are usually interpreted with such models as BET or GAB that imply the formation of multilayers at solid-gas interface.	Water	0-5	delta/notch like EGF repeat containing	Homo sapiens	81-84
11101628-7	2000	The segmental, cellular, and subcellular distribution of CA XII along the human nephron and collecting duct suggests that it may be one of the key enzymes involved in normal renal physiology, particularly in the regulation of water homeostasis.	Water	226-231	carbonic anhydrase 12	Homo sapiens	57-63
12369739-3	2002	Under conditions of equilibrated water metabolism TRH diminished significantly the hypothalamic and neurohypophysial AVP and OT content but was without the effect on plasma oxytocin level; however, TRH in a dose of 100 ng/100 g b.w.	Water	33-38	thyrotropin releasing hormone	Rattus norvegicus	50-53
12369739-11	2002	Data from the present study suggest that TRH displays different character of action on vasopressin and oxytocin secretion in relation to the actual state of water metabolism.	Water	157-162	thyrotropin releasing hormone	Rattus norvegicus	41-44
12213495-0	2002	TRH decreases food intake and increases water intake and body temperature in rats.	Water	40-45	thyrotropin releasing hormone	Rattus norvegicus	0-3
19931935-7	2010	The results showed that the expression of GhMYB25 and GhEXP1 showed significant difference in XinFLM after -1 DPA ovule treated for 24h relative to the untreated or H2O-treated ovules, with the expression of GhMYB25 increased significantly and that of GhEXP1 decreased.	Water	165-168	expansin-A4-like	Gossypium hirsutum	54-60
12213495-2	2002	In the present study, we investigated the effects of acute and chronic TRH treatment on water intake, body temperature and feeding behavior in rats.	Water	88-93	thyrotropin releasing hormone	Rattus norvegicus	71-74
12213495-4	2002	TRH decreased food and water intake in the first few hours (P &lt; .05).	Water	23-28	thyrotropin releasing hormone	Rattus norvegicus	0-3
12213495-9	2002	These results show that whereas a single injection of TRH decreases short-term food and water intake in rats, repeated daily treatments stimulate water intake but not food intake, and, thus, the increase in water consumption is mediated independently of food intake under these conditions.	Water	88-93	thyrotropin releasing hormone	Rattus norvegicus	54-57
11180637-2	2000	In the presence of water, HN-1 (bis(2-choroethyl)ethylamine), HN-2 and HN-3 undergo hydrolysis to form N-ethyldiethanolamine, N-methyldiethanolamine and triethanolamine (TEA), respectively; these compounds can be readily detected as adsorbed species on soil particles.	Water	19-24	Jupiter microtubule associated homolog 1	Homo sapiens	26-30
11180637-2	2000	In the presence of water, HN-1 (bis(2-choroethyl)ethylamine), HN-2 and HN-3 undergo hydrolysis to form N-ethyldiethanolamine, N-methyldiethanolamine and triethanolamine (TEA), respectively; these compounds can be readily detected as adsorbed species on soil particles.	Water	19-24	MT-RNR2 like 2 (pseudogene)	Homo sapiens	62-66
20127667-1	2010	A facile way to synthesize nanometer-sized polymer (polypyrrole, PPy) particles is explored on the basis of the formation of complexes between water-soluble polymers and metal cations in aqueous solution.	Water	143-148	pancreatic polypeptide	Homo sapiens	65-68
10925182-7	2000	The growing awareness about burns prevention among school children and community members, and steady increase in the number of patients who use water as first aid, speak about the success of the strategies.	Water	144-149	activation induced cytidine deaminase	Homo sapiens	159-162
11063906-0	2000	Mitochondrial or cytosolic catalase reverses the MnSOD-dependent inhibition of proliferation by enhancing respiratory chain activity, net ATP production, and decreasing the steady state levels of H(2)O(2).	Water	196-201	superoxide dismutase 2	Homo sapiens	49-54
12173922-1	2002	Cytochrome c oxidase catalyzes the one-electron oxidation of four molecules of cytochrome c and the four-electron reduction of dioxygen to water.	Water	139-144	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
12160936-3	2002	Upon exposure to GD or H(2)O(2), uninfected and Lac-Z-expressing astrocytes showed an immediate, rapid increase in ROS accumulation that was slowed and or reduced by Bcl-x(L).	Water	23-28	BCL2-like 1	Mus musculus	166-174
20104849-5	2010	However, the amount of variation in milk delta(2)H and delta(18)O values explained by tap water was low, suggesting a single estimation of fluid input isotope ratios may not always be adequate in studies.	Water	90-95	tracheal antimicrobial peptide	Bos taurus	86-89
20039357-9	2010	By combining the data obtained from the isotherms, AFM, water contact angle measurements, and UV/Vis and fluorescence spectra, the fibers are suggested to be formed by pi-pi stacking interaction of the aromatic rod segments as the oligo(ethylene oxide) branches are submerged in the water subphase upon compression.	Water	283-288	afamin	Homo sapiens	51-54
12153575-0	2002	NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol.	Water	53-56	Vpr	Human immunodeficiency virus 1	46-49
12137539-2	2002	The yields of ssb and dsb increase slightly on increasing the level of hydration (Gamma) from vacuum-dried DNA up to DNA containing 15 mol of water per mole of nucleotide.	Water	142-147	small RNA binding exonuclease protection factor La	Homo sapiens	14-17
11071817-3	2000	This involved measuring the effect of centrally administered antisense ODNs on water drinking that occurred in response to intracerebroventricular injection of hog renin.	Water	79-84	renin	Rattus norvegicus	164-169
19920212-6	2010	Water turnover was increased in chronic ACTH-treated mice, as were hematocrit and hypertonicity: volume contraction is consistent with high levels of glucocorticoid.	Water	0-5	pro-opiomelanocortin-alpha	Mus musculus	40-44
12084581-0	2002	Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin.	Water	46-51	aquaporin 10	Homo sapiens	61-66
12084581-11	2002	When expressed in Xenopus oocytes, AQP10 stimulated osmotic water permeability sixfold in a mercury-sensitive manner.	Water	60-65	aquaporin 10	Homo sapiens	35-40
20098770-6	2010	Despite the low solubility constant of PbS in water (K(sp) = 3.4 x 10(-28)), 53% +/- 2.25 (SD) (n = 3) of the Pb was leached after ca.	Water	46-51	cholinergic receptor muscarinic 3	Homo sapiens	39-42
12123814-2	2002	Two NIPs, soybean nodulin 26 and Lotus japonicus LIMP2, show a distinct functional profile with a low intrinsic osmotic water permeability (P(f)) and the ability to flux uncharged polyols such as glycerol.	Water	120-125	LIMP2	Lotus japonicus	49-54
11010887-8	2000	When larger volumes of water (up to 40 liters) were tested after elution and concentration with PEG, 38, 19, and 14% of the seeded Pan-1 were recovered from finished, ground, and surface waters, respectively.	Water	23-28	NLR family pyrin domain containing 2	Homo sapiens	131-136
11010887-9	2000	The limit of detection of Pan-1 by RT-PCR was estimated to be 0.75 to 1.5 PFU in 40 liters of finished water.	Water	103-108	NLR family pyrin domain containing 2	Homo sapiens	26-31
19916574-0	2010	A molecular dynamics study of human defensins HBD-1 and HNP-3 in water.	Water	65-70	defensin alpha 3	Homo sapiens	56-61
11023550-13	2000	Dietary haem increased faecal cation content and cytolytic activity of faecal water at all fat levels, suggesting that the colonic mucosa was exposed to high amounts of luminal irritants.	Water	78-83	FAT atypical cadherin 1	Rattus norvegicus	91-94
12510881-0	2002	De novo ligand design with explicit water molecules: an application to bacterial neuraminidase.	Water	36-41	neuraminidase 1	Homo sapiens	81-94
12510881-2	2002	In this paper, our de novo ligand design methods are applied to the X-ray crystal structure of bacterial neuraminidase in the presence of some selected water molecules.	Water	152-157	neuraminidase 1	Homo sapiens	105-118
20503471-2	2010	In the in vitro study, we found the earthworm (EW) water extracts caused a marked enhancement of the nerve growth factor-mediated neurite outgrowth from PC12 cells as well as the expressions of growth associated protein 43 and synapsin I.	Water	51-56	growth associated protein 43	Rattus norvegicus	194-222
12091474-4	2002	Pretreatment for 14 days with 7 mm of lithium carbonate in drinking water prevents aluminum-induced translocation of cytochrome c, and up-regulates Bcl-2 and Bcl-X(L,) down-regulates Bax, abolishes caspase-3 activity and reduces DNA damage.	Water	68-73	cytochrome c	Oryctolagus cuniculus	117-129
11013071-1	2000	The renin angiotensin system (RAS) is involved in blood pressure control and water/sodium metabolism.	Water	77-82	renin	Pan troglodytes	4-9
20378983-3	2010	By proteomic analysis using rats with gastric ulcer induced by water immersion and restraint (WIR) stress as an animal model, we found quantitative changes in several serum proteins, including creatine kinase muscle M chain (CK-M) and apolipoprotein A-IV (ApoA4) in the stressed rats.	Water	63-68	creatine kinase, M-type	Rattus norvegicus	193-223
10952910-3	2000	Large increases in water content in the PS (20%) occurred in pregnant (Day 18.5) wild-type (rlx +/+) mice but not in rlx -/- animals.	Water	19-24	relaxin 1	Mus musculus	92-95
10990371-3	2000	AQP1 deletion reduces osmotic water permeability in the proximal tubule, thin descending limb of Henle and vasa recta, resulting in defective proximal tubule fluid absorption and medullary countercurrent exchange.	Water	30-35	aquaporin 1	Mus musculus	0-4
11077330-1	2000	Water-coupled Na&amp;sup+ absorption in the colon is mediated principally by Na+/H+ exchange (isoforms NHE2 and NHE3).	Water	0-5	solute carrier family 9 member A3	Rattus norvegicus	112-116
11130945-1	2000	We utilize T-cell HPRT mutations to monitor exposure to environmental mutagens in siblings of children who have developed cancer at a persistently high rate in Toms River, New Jersey, U.S.A. A preliminary epidemiological study has found a statistically-significant association between drinking public water (by pregnant mother or infant) and subsequent risk for childhood cancer.	Water	301-306	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	18-22
10989886-0	2000	Solvation of Cr3+ cation in water-acetonitrile mixture studied by IR spectroscopy: molecular penetration into the solvation shells.	Water	28-33	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	13-16
10989886-4	2000	The character of changes of the integral intensities of the subbands with time for various H2O:Cr3+ molar ratios are explained by suggesting mechanisms of molecular replacement within the solvation shells of Cr3+.	Water	91-94	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	95-98
10989886-4	2000	The character of changes of the integral intensities of the subbands with time for various H2O:Cr3+ molar ratios are explained by suggesting mechanisms of molecular replacement within the solvation shells of Cr3+.	Water	91-94	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	208-211
10866938-0	2000	Application of the primary hydration shell approach to locally enhanced sampling simulated annealing: computer simulation of thyrotropin-releasing hormone in water.	Water	158-163	thyrotropin releasing hormone	Homo sapiens	125-154
10860601-0	2000	Adhesion between Silica Particle and Mica Surfaces in Water and Electrolyte Solutions.	Water	54-59	MHC class I polypeptide-related sequence A	Homo sapiens	37-41
11031459-4	2000	The development of complications leads to staging in ABC, its stages being as follows: stage I--the initial stage, stage II--persisting metabolic acidosis and respiratory alkalosis, stage III--alkalosis, stage IV--normalization, with stage III of ABS being encouraged by hypocapnia caused by function disorders of the lungs in early posthemorrhagic period, normalization of cell metabolism, increase in the rate of urination as a reflection of the third earlier identified stage of water metabolism, with the H+ excretion in the urine at the previous level.	Water	482-487	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	53-56
10857362-0	2000	Photosensitized reduction of methyl viologen using eosin-Y in presence of a sacrificial electron donor in water-alcohol mixture Photoreduction of methyl viologen (MV2+) by eosin-Y (EY2-) in the presence of triethanolamine (TEOA) has been investigated in water-methanol mixture by means of steady-state photolysis and laser-flash photolysis in the visible/near-infrared regions.	Water	254-259	ENY2 transcription and export complex 2 subunit	Homo sapiens	181-184
10806347-13	2000	These results suggest that AZF1, AZF2, AZF3, and STZ are all involved in the water-stress response in an ABA-dependent or -independent pathway to regulate downstream genes.	Water	77-82	zinc-finger protein 2	Arabidopsis thaliana	33-37
10806347-13	2000	These results suggest that AZF1, AZF2, AZF3, and STZ are all involved in the water-stress response in an ABA-dependent or -independent pathway to regulate downstream genes.	Water	77-82	zinc-finger protein 3	Arabidopsis thaliana	39-43
10953459-2	2000	beta-Galactosidase secreted by the callus culture, or the roots of sprouting plants, hydrolyzes the substrate (6-bromo-2-naphthyl-beta-D-galactopyranoside) to produce beta-D-galactose and 6-bromo-2-naphthol, which after simultaneous azocoupling with hexazotized p-rosaniline, or basic fuchsine, produce a reddish brown compound, nearly insoluble in water (a diazonium salt).	Water	349-354	galactosidase beta 1	Homo sapiens	0-18
10810233-2	2000	The function of endothelin 3 (Et3) at the renal level is debatable, but it could have an important regulatory function in the reabsorption of water through its action on tubular type B receptors.	Water	142-147	endothelin 3	Rattus norvegicus	16-28
10771051-0	2000	Increasing the thermal stability of the water-soluble pyrroloquinoline quinone glucose dehydrogenase by single amino acid replacement.	Water	40-45	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	79-100
10771051-1	2000	Based on the characterization of a PCR mutation of water-soluble glucose dehydrogenase possessing pyrroloquinoline quinone (PQQ), PQQGDH-B, Ser231Cys, we have constructed a series of Ser231 variants.	Water	51-56	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	65-86
10702234-2	2000	We investigated the effects of external pH and Ca(2+) on water permeability of Xenopus oocytes injected with aquaporin cRNA by measuring the rate of swelling in hypotonic solutions.	Water	57-62	aquaporin	Xenopus laevis	109-118
10702234-3	2000	Lowering pH to 6.5 increased the water permeability of aquaporin (AQP0) 3.4 +/- 0.4-fold.	Water	33-38	aquaporin	Xenopus laevis	55-64
10702234-11	2000	Because the greatest change in AQP0 water permeability is in the normal pH range found in the lens (7.2-6.5), this paper provides evidence for regulation of an aquaporin by pH under physiological conditions.	Water	36-41	aquaporin	Xenopus laevis	160-169
10746821-9	2000	Thus, in rats with CHF, AT1 expression is increased in brain regions that are closely related to water intake, vasopressin release, and hemodynamic regulation.	Water	97-102	angiotensin II receptor, type 1a	Rattus norvegicus	24-27
10700504-1	2000	BACKGROUND AND PURPOSE: Continuous arterial spin-labeled perfusion MRI (CASL-PI) uses electromagnetically labeled arterial blood water as a diffusible tracer to noninvasively measure cerebral blood flow (CBF).	Water	129-134	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	72-76
10640652-4	2000	When acidic gelatin hydrogels incorporating 125I-labeled TGF-beta1 were implanted into the back subcutis of mice, the radioactivity decreased with time and the in vivo retention of TGF-beta1 was prolonged with a decrease in the water content of hydrogels.	Water	228-233	transforming growth factor, beta 1	Mus musculus	57-66
10662724-5	2000	RT-PCR of microdissected segments showed that the water channel aquaporin-1 (AQP1) and the urea transporter UT-A2 were expressed in pure DTL, but not in pure ATL, and in DTL-type, but not in ATL-type, regions of mixed-type thin limbs.	Water	50-55	denticleless E3 ubiquitin protein ligase homolog	Homo sapiens	137-140
10662724-5	2000	RT-PCR of microdissected segments showed that the water channel aquaporin-1 (AQP1) and the urea transporter UT-A2 were expressed in pure DTL, but not in pure ATL, and in DTL-type, but not in ATL-type, regions of mixed-type thin limbs.	Water	50-55	denticleless E3 ubiquitin protein ligase homolog	Homo sapiens	170-173
10695990-1	2000	Expression of cyclooxygenase (COX)-2 protein in preneoplastic and neoplastic lung lesions induced by the administration of 2000 ppm of N-nitrosobis(2-hydroxypropyl)amine (BHP) in the drinking water to Wistar male rats, was examined immunohistochemically.	Water	192-197	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	14-36
10679502-9	2000	The renoprotective effects of HRI were at least in part due to improved renal hemodynamics and distal tubular function, since HRI shifted renal pressure-diuresis/natriuresis curves leftward by approximately 35 mm Hg, increased glomerular filtration rate and renal blood flow, and shifted the fractional water and sodium excretion curves leftward.	Water	303-308	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	30-33
10679502-9	2000	The renoprotective effects of HRI were at least in part due to improved renal hemodynamics and distal tubular function, since HRI shifted renal pressure-diuresis/natriuresis curves leftward by approximately 35 mm Hg, increased glomerular filtration rate and renal blood flow, and shifted the fractional water and sodium excretion curves leftward.	Water	303-308	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	126-129
10644730-1	2000	Measurements of CO(2) permeability in oocytes and liposomes containing water channel aquaporin-1 (AQP1) have suggested that AQP1 is able to transport both water and CO(2).	Water	71-76	aquaporin 1	Mus musculus	85-96
10644730-1	2000	Measurements of CO(2) permeability in oocytes and liposomes containing water channel aquaporin-1 (AQP1) have suggested that AQP1 is able to transport both water and CO(2).	Water	71-76	aquaporin 1	Mus musculus	98-102
10644730-1	2000	Measurements of CO(2) permeability in oocytes and liposomes containing water channel aquaporin-1 (AQP1) have suggested that AQP1 is able to transport both water and CO(2).	Water	71-76	aquaporin 1	Mus musculus	124-128
10644730-1	2000	Measurements of CO(2) permeability in oocytes and liposomes containing water channel aquaporin-1 (AQP1) have suggested that AQP1 is able to transport both water and CO(2).	Water	155-160	aquaporin 1	Mus musculus	85-96
10644730-1	2000	Measurements of CO(2) permeability in oocytes and liposomes containing water channel aquaporin-1 (AQP1) have suggested that AQP1 is able to transport both water and CO(2).	Water	155-160	aquaporin 1	Mus musculus	98-102
10644730-1	2000	Measurements of CO(2) permeability in oocytes and liposomes containing water channel aquaporin-1 (AQP1) have suggested that AQP1 is able to transport both water and CO(2).	Water	155-160	aquaporin 1	Mus musculus	124-128
10644730-10	2000	Whereas osmotic water permeability in AQP1-reconstituted liposomes was &gt;100-fold greater than that in control liposomes, apparent P(CO(2)) (approximately 10(-3) cm/s) did not differ.	Water	16-21	aquaporin 1	Mus musculus	38-42
10691781-7	2000	In the gastrointestinal tract, physiological quantities of ANG II stimulate the AT2 receptor releasing NO and cGMP leading to increased sodium and water absorption.	Water	147-152	angiotensin II receptor type 2	Homo sapiens	80-83
10680722-8	2000	Rats given a choice of 2% w/v ethanol and water decreased alcohol preference after TRH (20 mg/kg) but did not reduce total fluid intake.	Water	42-47	thyrotropin releasing hormone	Rattus norvegicus	83-86
11140363-7	2000	Similar up-regulation of TAUT was observed in the small intestine of water-deprived rats.	Water	69-74	solute carrier family 6 member 6	Homo sapiens	25-29
10654821-6	2000	EP1 and EP3 messenger RNA expression predominate in the collecting duct and thick limb, respectively, where their stimulation reduces sodium chloride and water absorption, promoting natriuresis and diuresis.	Water	154-159	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	8-11
12091474-4	2002	Pretreatment for 14 days with 7 mm of lithium carbonate in drinking water prevents aluminum-induced translocation of cytochrome c, and up-regulates Bcl-2 and Bcl-X(L,) down-regulates Bax, abolishes caspase-3 activity and reduces DNA damage.	Water	68-73	apoptosis regulator BAX	Oryctolagus cuniculus	183-186
12091474-4	2002	Pretreatment for 14 days with 7 mm of lithium carbonate in drinking water prevents aluminum-induced translocation of cytochrome c, and up-regulates Bcl-2 and Bcl-X(L,) down-regulates Bax, abolishes caspase-3 activity and reduces DNA damage.	Water	68-73	caspase-3	Oryctolagus cuniculus	198-207
12208125-7	2002	The increased expression of AQP1-3 channels may in part account for the water retention in hypothyroidism.	Water	72-77	aquaporin 1	Rattus norvegicus	28-32
12164487-5	2002	IES shows that the dehydroxylation occurs as a continuous process in comparison to DTA/TGA studies where the dehydroxylation occurs abruptly at 425 degrees C. Water in these high iron bearing smectites have been observed through the stretching mode at 3430 cm(-1) and the bending mode at 1630 cm(-1).	Water	159-164	T-box transcription factor 1	Homo sapiens	87-90
12054859-8	2002	Electrostatically steered eIF4E-cap association is accompanied by additional hydration of the complex by approximately 65 water molecules, and by ionic equilibria shift.	Water	122-127	eukaryotic translation initiation factor 4E	Homo sapiens	26-31
12162729-5	2002	Mice lacking AQP1 manifest defective urinary concentrating ability, in part because of decreased water permeability in renal vasa recta microvessels.	Water	97-102	aquaporin 1	Mus musculus	13-17
12162729-8	2002	However, AQP1 in most endothelial tissues does not appear to have a physiological function despite its role in osmotically driven water transport.	Water	130-135	aquaporin 1	Mus musculus	9-13
12162729-9	2002	For example, mice lacking AQP1 have low alveolar-capillary water permeability but unimpaired lung fluid absorption, as well as unimpaired saliva and tear secretion, aqueous fluid outflow, and pleural and peritoneal fluid transport.	Water	59-64	aquaporin 1	Mus musculus	26-30
11982430-2	2002	The HDLG was prepared by heating solutions of 4% beta-LG in deionized water, pH 7.0, at 80 degrees C for 30 min and then diluted to the desired concentration in 0.6 M NaCl and 0.05 M phosphate buffer at pH 6.0, 6.5, and 7.0.	Water	70-75	discs large MAGUK scaffold protein 1	Homo sapiens	4-8
12195567-0	2002	Alternative treatment of psoriasis with balneotherapy using Leopoldine spa water.	Water	75-80	surfactant protein A1	Homo sapiens	71-74
12195567-1	2002	BACKGROUND: Leopoldine spa water is a hypotonic water rich in sulphate that has been used occasionally for balneological treatments in psoriatics.	Water	27-32	surfactant protein A1	Homo sapiens	23-26
11914078-10	2002	Specifically, a new protein dipole is introduced into the heme microenvironment as a result of the F65Y mutation, two new internal water molecules (one in hydrogen-bonding distance of Y65) are found, and in the case of F61I/F65Y/R106L (DeltaE(m) = 158 mV vs NHE), increased solvent exposure of the heme as a result of the R106L substitution is identified.	Water	131-136	solute carrier family 9 member C1	Homo sapiens	258-261
12194025-5	2002	Determination of the analytes in spiked river water samples by use of the dmAChE biosensor resulted in recoveries from 50 to 90 % for chlorpyrifos oxon at levels of 20 to 40 nmol L(-1), 50 to 100 % for paraoxon at 0.6 to 0.8 micro mol L(-1), and 140 to 190 % for malaoxon at 0.6 to 1.2 micro mol L(-1).	Water	46-51	Acetylcholine esterase	Drosophila melanogaster	74-80
11976068-5	2002	Vtg induction (LOEC) occurred in whole body homogenate at actual water concentrations of 21 ng E2/l and 3.0 ng EE2/l, respectively.	Water	65-70	vitellogenin	Danio rerio	0-3
11979726-2	2002	The heterozygous mice for the tyrosine hydroxylase (TH) gene and for the cyclic AMP (cAMP) response element binding protein (CREB) binding protein (CBP) gene showed the impairment of latent learning in the water finding task, and these mice did not develop morphine dependence.	Water	206-211	tyrosine hydroxylase	Mus musculus	30-50
11979726-2	2002	The heterozygous mice for the tyrosine hydroxylase (TH) gene and for the cyclic AMP (cAMP) response element binding protein (CREB) binding protein (CBP) gene showed the impairment of latent learning in the water finding task, and these mice did not develop morphine dependence.	Water	206-211	tyrosine hydroxylase	Mus musculus	52-54
11943215-1	2002	Nuclear magnetic resonance (NMR) spectroscopy reveals that higher-order aggregates of glucagon-like peptide-1-(7-36)-amide (GLP-1) in pure water at pH 2.5 are disrupted by 35% 2,2,2-trifluoroethanol (TFE), and form a stable and highly symmetric helical self-aggregate.	Water	139-144	glucagon like peptide 1 receptor	Homo sapiens	124-129
11890789-0	2002	Micelle-induced curvature in a water-insoluble HIV-1 Env peptide revealed by NMR dipolar coupling measurement in stretched polyacrylamide gel.	Water	31-36	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	53-56
11962736-5	2002	These results suggest that TLR2 signaling is at least partly involved in the antitumor activity of the water-soluble antitumor glycoprotein from C. vulgaris.	Water	103-108	toll-like receptor 2	Mus musculus	27-31
11851411-11	2002	Since the rates of global unfolding measured by near-UV CD and fluorescence agree well with the rates of exposure determined for all of the backbone NH probe protons, it appears that the rate-limiting step for the unfolding of RNase A is the dissolution of the entire native tertiary structure and penetration of water into the hydrophobic core.	Water	313-318	ribonuclease A family member 1, pancreatic	Homo sapiens	227-234
11805186-11	2002	These findings suggest a role for Ang1 in the maintenance of the glomerular endothelium and make it a good candidate to be a regulator of the actions of VEGF on glomerular permeability, resisting angiogenesis while allowing the induction of high permeability to water and small solutes.	Water	262-267	angiopoietin 1	Homo sapiens	34-38
11782167-5	2002	These complexes add water at room temperature, giving rise to the oxidative addition products syn-[(DMSO)2HIr(mu-OH)2(mu-Cl)IrH(DMSO)2] [IrCl2(DMSO)2] (3) and anti-[(DMSO)2(DMSO)HIr(mu-OH)2IrH(DMSO)2(DMSO)](PF6)2 (7), respectively.	Water	20-25	sperm associated antigen 17	Homo sapiens	207-210
11741725-2	2002	At least two aquaporin-type water channels are expressed in spinal cord: AQP1 in afferent sensory nerve fibers in the superficial layers of the dorsal horn, and AQP4 in glial cells throughout gray matter.	Water	28-33	aquaporin 1	Mus musculus	73-77
12067101-0	2002	Anti-hypertensive effect of water extract of danshen on renovascular hypertension through inhibition of the renin angiotensin system.	Water	28-33	renin	Rattus norvegicus	108-113
12189621-5	2002	Finally, anti-MIF antibody suppressed EAU when administered in the early phase.	Water	38-41	macrophage migration inhibitory factor	Homo sapiens	14-17
12386288-9	2002	Immediate induction of MK expression was observed when cultured tubular epithelial cells (TEpiCs) were exposed to 5 mM H(2)O(2).	Water	119-124	midkine	Mus musculus	23-25
11803240-2	2002	Studies on the effects of GH on body weight and food and water intake are scarce and have yielded controversial results.	Water	57-62	gonadotropin releasing hormone receptor	Rattus norvegicus	26-28
11803240-11	2002	Thus, injection of GH appears to modify food intake-related behavior, since the periods of enhanced food and water intake were shifted from night- to daytime.	Water	109-114	gonadotropin releasing hormone receptor	Rattus norvegicus	19-21
11773613-9	2002	AQP7 is abundant in the brush border of proximal tubule cells and is likely to be involved in proximal tubule water reabsorption.	Water	110-115	aquaporin 7	Homo sapiens	0-4
11679578-1	2001	Human cofilin possesses the tendency for self-association, as indicated by the rapid formation of dimers and oligomers when reacted with water-soluble carbodiimide, Ellman"s reagent, or glutathione disulfide.	Water	137-142	cofilin 1	Homo sapiens	6-13
11775163-6	2001	The major arsenic species in a water extract of a poultry litter sample was identified as ROX by all three methods with trace concentrations of DMA and As(V) also detected.	Water	31-36	ribosomal oxygenase 1	Homo sapiens	90-93
11705786-1	2001	The major intrinsic protein (MIP) of lens fiber cells is a member of the aquaporin (AQP) water channel family.	Water	89-94	major intrinsic protein of lens fiber b	Fundulus heteroclitus	4-27
11705786-1	2001	The major intrinsic protein (MIP) of lens fiber cells is a member of the aquaporin (AQP) water channel family.	Water	89-94	major intrinsic protein of lens fiber b	Fundulus heteroclitus	29-32
11783791-8	2001	A partial transfer of the [CoX4]2- species from a "water pool" into the CHCl3 phase by the addition of the metal salts may be suspected.	Water	51-56	cytochrome c oxidase subunit 4I2	Homo sapiens	27-33
11717653-2	2001	STUDY DESIGN: Inactivated GBS antigen was microencapsulated in poly (D, L-lactic-co-glycolic acid) (PLG) with a water-in-oil-in-water double emulsion technique.	Water	112-117	plasminogen	Mus musculus	100-103
11717653-2	2001	STUDY DESIGN: Inactivated GBS antigen was microencapsulated in poly (D, L-lactic-co-glycolic acid) (PLG) with a water-in-oil-in-water double emulsion technique.	Water	128-133	plasminogen	Mus musculus	100-103
11701288-7	2001	Using simultaneous EEG and rectal temperature monitoring during hot water immersion, we showed that epileptic discharges increased in frequency, and eventually developed into seizures at temperatures over 38 degrees C. We believe that the unique fever sensitivity observed in SME is similar to, but more intense than that of febrile convulsions.	Water	68-73	small nuclear ribonucleoprotein polypeptide E	Homo sapiens	276-279
11675398-4	2001	Water loading lowered urine osmolality and mRNA expression of sodium/myo-inositol cotransporter (SMIT), a target gene of TonEBP, in the renal medulla; dehydration doubled the urine osmolality and increased SMIT mRNA expression.	Water	0-5	solute carrier family 5 member 3	Rattus norvegicus	62-95
11675398-4	2001	Water loading lowered urine osmolality and mRNA expression of sodium/myo-inositol cotransporter (SMIT), a target gene of TonEBP, in the renal medulla; dehydration doubled the urine osmolality and increased SMIT mRNA expression.	Water	0-5	solute carrier family 5 member 3	Rattus norvegicus	97-101
11675398-4	2001	Water loading lowered urine osmolality and mRNA expression of sodium/myo-inositol cotransporter (SMIT), a target gene of TonEBP, in the renal medulla; dehydration doubled the urine osmolality and increased SMIT mRNA expression.	Water	0-5	nuclear factor of activated T-cells 5	Rattus norvegicus	121-127
11675398-4	2001	Water loading lowered urine osmolality and mRNA expression of sodium/myo-inositol cotransporter (SMIT), a target gene of TonEBP, in the renal medulla; dehydration doubled the urine osmolality and increased SMIT mRNA expression.	Water	0-5	solute carrier family 5 member 3	Rattus norvegicus	206-210
11703585-12	2001	COX-2 inhibitors might be valuable drugs to treat salt and water wasting during Bartter and Gitelman diseases.	Water	59-64	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5
11703600-8	2001	Switching from NaHCO(3) to distilled water resulted in rapid recovery of NHE-3 and NBC-1 protein expression toward normal levels.	Water	37-42	solute carrier family 9 member A3	Rattus norvegicus	73-78
11597586-11	2001	On the other side, brain areas activated by neurokinin B are known to be involved in the central regulation of blood pressure, water and salt homeostasis or control of behaviour.	Water	127-132	tachykinin precursor 3	Rattus norvegicus	44-56
11574461-4	2001	Furthermore, the residues that usually co-ordinate Mg(2+) through water molecules in the GTP-binding proteins, though conserved in SsEF-1alpha, are located quite far from the binding site.	Water	66-71	ribosomal protein S18-alanine N-acetyltransferase	Saccharolobus solfataricus	131-142
10642600-0	2000	Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta.	Water	43-48	aquaporin 1	Mus musculus	15-26
10642600-1	2000	Deletion of AQP1 in mice results in diminished urinary concentrating ability, possibly related to reduced NaCl- and urea gradient-driven water transport across the outer medullary descending vasa recta (OMDVR).	Water	137-142	aquaporin 1	Mus musculus	12-16
10758912-5	2000	Plasmids encoding nuclear localizing beta galactosidase or luciferase (pRSVLuc, pCLuc4, pSV2Luc) were complexed in water at various +/- charge ratios using cationic lipids (Lipofectin, DOTAP, DOGS), polyethylene imines (25 and 750 kDa), and with degraded 6th generation starburst polyamidoamine dendrimers.	Water	115-120	galactosidase beta 1	Homo sapiens	37-55
11578960-8	2001	Perhaps, through its hydrophilicity, the MUC5B mucin holds water in place at the endocervical canal surface at midcycle, keeping the canal patent for sperm motility.	Water	59-64	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	41-46
20378983-3	2010	By proteomic analysis using rats with gastric ulcer induced by water immersion and restraint (WIR) stress as an animal model, we found quantitative changes in several serum proteins, including creatine kinase muscle M chain (CK-M) and apolipoprotein A-IV (ApoA4) in the stressed rats.	Water	63-68	creatine kinase, M-type	Rattus norvegicus	225-229
11578960-8	2001	Perhaps, through its hydrophilicity, the MUC5B mucin holds water in place at the endocervical canal surface at midcycle, keeping the canal patent for sperm motility.	Water	59-64	LOC100508689	Homo sapiens	47-52
10640681-0	1999	Water deprivation upregulates the three calmodulin genes in exclusively the supraoptic nucleus of the rat brain.	Water	0-5	calmodulin 1	Rattus norvegicus	40-50
20930427-8	2010	A defect of mitochondrial NDUFV1 may reduce complex I, which produces most of the superoxide, which is then scavenged by the mitochondrial enzyme Mn-superoxide dismutase to produce H(2)O(2).	Water	181-186	superoxide dismutase 2	Homo sapiens	146-169
10640681-3	1999	In this study, the expression of the three CaM genes in response to osmotic stimuli by water deprivation was investigated in the rat brain, with particular interest as concerns the hypothalamic magnocellular nuclei.	Water	87-92	calmodulin 1	Rattus norvegicus	43-46
28060640-6	1999	Water suppresses CH3Br decomposition and also affects the yields of COx (CO and CO2) and organic byproducts due to the involvement of some active species generated from water.	Water	0-5	cytochrome c oxidase subunit 8A	Homo sapiens	68-71
28060640-6	1999	Water suppresses CH3Br decomposition and also affects the yields of COx (CO and CO2) and organic byproducts due to the involvement of some active species generated from water.	Water	169-174	cytochrome c oxidase subunit 8A	Homo sapiens	68-71
11600024-4	2001	The calculated polychromatic quantum efficiencies (Phi(solvent)) of acifluorfen in different solvents are as follows (units are degraded molecules photon(-1)): Phi(water) = 10(-4), Phi(acetonitrile) = 10(-4), Phi(methanol) = 10(-4), and Phi(hexane) = 10(-2).	Water	164-169	glucose-6-phosphate isomerase	Homo sapiens	51-54
20040152-4	2010	The time profile of SDF-1 release from the hydrogel of succinylated gelatin could be controlled by changing the water content of hydrogel which could be modified by changing the conditions of hydrogel preparation.	Water	112-117	C-X-C motif chemokine ligand 12	Homo sapiens	20-25
11684018-2	2001	The 1.7 A X-ray crystal structure of the PX domain from the p40(phox) subunit of NADPH oxidase bound to PtdIns(3)P shows that the PX domain embraces the 3-phosphate on one side of a water-filled, positively charged pocket and reveals how 3-phosphoinositide specificity is achieved.	Water	182-187	interleukin 9	Homo sapiens	60-114
11395509-4	2001	In-line attack by water onto the gamma-phosphate of ATP would be followed first by formation of a trigonal intermediate and then by breaking of the scissile bond between the beta- and gamma-phosphates.	Water	18-23	ATPase	Escherichia coli	52-55
10550237-1	1999	Langmuir-Blodgett films of 4-heptoxy-4"-carboxyazobenzene on mica transferred from pure water exhibit novel strip structures consisting of mono-molecular thick straight bands 80 nm wide and more than 100 microm long.	Water	88-93	MHC class I polypeptide-related sequence A	Homo sapiens	61-65
20616615-1	2010	OBJECTIVES: Hyaluronan, a major water binding component of the extracellular matrix, is synthesised within the cytosol and exported across the plasma membrane by the ABC-transporter MRP5 in fibroblasts.	Water	32-37	ATP binding cassette subfamily C member 5	Homo sapiens	182-186
11500875-0	2001	Catalytic Use of a Boron Source for Boron Enolate Mediated Stereoselective Aldol Reactions in Water This work was partially supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture, Japan.	Water	94-99	activation induced cytidine deaminase	Homo sapiens	148-151
20351429-5	2010	However, in estuary water samples containing relatively high concentration of sewage contamination, a linear correlation does exist between BOD(5) and COD.	Water	20-25	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	151-154
11466049-4	2001	The [(beta-CD-ttp)Ru(ttp)][PF(6)](2) metalloreceptor exhibits luminescence in water, centered at 640 nm, from the (3)MLCT state with a lifetime of 1.9 ns and a quantum yield of Phi = 4.1 x 10(-)(5).	Water	78-83	SH3 domain binding protein 4	Homo sapiens	14-17
11466049-4	2001	The [(beta-CD-ttp)Ru(ttp)][PF(6)](2) metalloreceptor exhibits luminescence in water, centered at 640 nm, from the (3)MLCT state with a lifetime of 1.9 ns and a quantum yield of Phi = 4.1 x 10(-)(5).	Water	78-83	SH3 domain binding protein 4	Homo sapiens	21-24
10607506-7	1999	On the basis of these results, distilled water as diluent and 2- PDS as chromophore are recommended for ChE determination in whole blood.	Water	41-46	CHE	Capra hircus	104-107
10608607-2	1999	U.S. EPA guidelines allow 10.6 micromol x L(-1) Ag+ in human drinking water for up to 10 d. Studies correlate Ag+ exposure with tissue dysfunction in humans, rats, and mice, and with altered ion transport, skeletal muscle contraction, and embryonic cell constriction in other animal cells.	Water	70-75	S100 calcium binding protein A8	Homo sapiens	42-50
19800950-4	2009	The water permeability of AQP4/V1(a)R-expressing oocytes was reduced in a vasopressin-dependent manner, as a result of V1(a)R-dependent internalization of AQP4.	Water	4-9	arginine vasopressin S homeolog	Xenopus laevis	74-85
10579058-2	1999	The major epithelial isoforms, NHE2 and NHE3, are thought to have more specialized roles in regulating Na+ and water absorption and are differentially expressed in epithelial tissues.	Water	111-116	solute carrier family 9 member A3	Rattus norvegicus	40-44
11464512-5	2001	The xenografts were found to express beta-gal when the animals were fed drinking water containing Dox.	Water	81-86	galactosidase beta 1	Homo sapiens	37-45
19968370-1	2009	Mechanical unfolding of the fourth domain of Distyostelium discoideum filamin (DDFLN4) was studied by all-atom molecular dynamics simulations, using the GROMOS96 force field 43a1 and the simple point charge explicit water solvent.	Water	216-221	filamin C	Homo sapiens	70-77
11461838-10	2001	Exposure of adult male zebrafish to EE2 via water induced a concentration-dependent induction of VTG with a lowest observed effect concentration (LOEC) &lt; or =1.67 ng EE2/l (for a 21-day exposure).	Water	44-49	vitellogenin	Danio rerio	97-100
11444478-6	2001	In the "diarrhoea" samples, elastase-1 levels were considerably higher after lyophilization--with a calculated normal water content of 75% (606 +/- 359 microg/g, mean +/- s)--compared to measurement when unprocessed (279 +/- 151 microg/g; P &lt; 0.0001).	Water	118-123	chymotrypsin like elastase 1	Homo sapiens	28-38
10580350-4	1999	A high insulin dose (1 U/kg/h) was required to normalize plasma glucose and fatty acid concentrations, water and food consumption, urine output, and body weight.	Water	103-108	insulin	Mesocricetus auratus	7-14
19966491-3	2009	Both the supernatant and the precipitate fractions were incubated with a phospholipase A(1) (PLA1) from Aspergillus orizae for 3.5 h. The PLA1-treated lipids were extracted with n-hexane/isopropanol, the hexane layer was obtained using a Na(2)SO(4) solution, and the hexane layer was further washed with water.	Water	304-309	lipase H	Homo sapiens	93-97
10477136-1	1999	Four prostaglandin E2 receptor subtypes designated EP1, EP2, EP3, and EP4 have been shown to mediate a variety of effects of prostaglandin E2 (PGE2) on glomerular hemodynamics, tubular salt and water reabsorption, and on blood vessels in the human kidney.	Water	194-199	prostaglandin E receptor 2	Homo sapiens	56-59
10532708-5	1999	Since the basis of fluid secretion is an active efflux of ions such as chloride stimulated by a humoral agent, accompanied by a passive diffusion of water across a cell wall, I hypothesize that hCG is also a secretory hormone and responsible for fluid fluxes in the above and other clinical situations.	Water	149-154	hypertrichosis 2 (generalised, congenital)	Homo sapiens	194-197
11403615-0	2001	The "wired" laccase cathode: high current density electroreduction of O(2) to water at +0.7 V (NHE) at pH 5.	Water	78-83	solute carrier family 9 member C1	Homo sapiens	95-98
19937006-1	2009	Persistence of intestinal lactase into adulthood allows humans to use milk from other mammals as a source of food and water.	Water	118-123	lactase	Homo sapiens	26-33
11747764-6	2001	Inject ion of L-AP3 600 nmol induced a great increase of brain water, Na+, and Ca2+ contents, and a decrease of brain K+ content (P &lt; 0.01).	Water	63-68	leucine aminopeptidase 3	Rattus norvegicus	14-19
11371450-8	2001	In addition, we obtain volumetric data for the transition of myelin basic protein from its initially unfolded state in water free of denaturants, to a folded, compact conformation within the water-controlled microenvironment of reverse micelles.	Water	119-124	myelin basic protein	Homo sapiens	61-81
11371450-8	2001	In addition, we obtain volumetric data for the transition of myelin basic protein from its initially unfolded state in water free of denaturants, to a folded, compact conformation within the water-controlled microenvironment of reverse micelles.	Water	191-196	myelin basic protein	Homo sapiens	61-81
11322882-0	2001	Conformational model for the consensus V3 loop of the envelope protein gp120 of HIV-1 in a 20% trifluoroethanol/water solution.	Water	112-117	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	71-76
11337875-7	2001	Overall, these studies show that the addition of high affinity sorbents effectively reduces pore-water PAH concentrations and bioavailability and suggests that sorbent addition may serve as an option for in situ remediation of some contaminated sediments.	Water	97-102	phenylalanine hydroxylase	Homo sapiens	103-106
12587203-1	2001	This paper reported the studies on the water purification of breeding Hirudo nippanica with photosynthesis bacteria (PBS).	Water	39-44	cholinergic receptor muscarinic 3	Homo sapiens	117-120
12587203-2	2001	The results showed the PBS could reduce effectively the chemical dissolved oxygen, NH(4+)-N, vulcanization and organic matter of water bottom, as well as improve the dissolved oxygen.	Water	129-134	cholinergic receptor muscarinic 3	Homo sapiens	23-26
11154696-3	2001	It has been proposed that in vivo lipase adsorption on oil-water emulsion is mediated by a preformed lipase-colipase-mixed micelle complex.	Water	59-64	colipase	Rattus norvegicus	108-116
11278374-2	2001	Since most previous in vitro investigations used micellar ganglioside GM2 as substrate, we studied the degradation of membrane-bound ganglioside GM2 by water-soluble beta-hexosaminidase A in the presence of the GM2 activator protein in a detergent-free, liposomal assay system.	Water	152-157	O-GlcNAcase	Homo sapiens	166-185
11411093-0	2001	Effects of water deprivation on neurokinin B production by the arginine-vasopressin neurons of hypothalamic paraventricular and supraoptic nuclei.	Water	11-16	tachykinin precursor 3	Rattus norvegicus	32-44
11411093-4	2001	Five days after water deprivation, AVP and NKB immunoreactivity decreased drastically, while NKBp-immunoreactivity increased in both the PVN and SON magnocellular neurons.	Water	16-21	tachykinin precursor 3	Rattus norvegicus	43-46
11411093-7	2001	After five days of water deprivation, AVP mRNA in the PVN and NKB mRNA in both the PVN and the SON increased considerably.	Water	19-24	tachykinin precursor 3	Rattus norvegicus	62-65
11411093-8	2001	These results indicate that synthesis and release of NKB, which colocalizes to AVP neurons, are enhanced by water deprivation in the same manner as AVP in the PVN and SON.	Water	108-113	tachykinin precursor 3	Rattus norvegicus	53-56
11231909-4	2001	JAK2 was activated rapidly in VSMCs treated with H(2)O(2), and signal transducers and activators of transcription (STAT) STAT1 and STAT3 were tyrosine-phosphorylated and translocated to the nucleus in a JAK2-dependent manner.	Water	49-54	signal transducer and activator of transcription 1	Rattus norvegicus	121-126
11288486-4	2001	The heterozygous mice for the tyrosine hydroxylase (TH) gene and for the cyclic AMP (cAMP) response element binding protein (CREB) binding protein (CBP) gene showed impairment of latent learning in the water finding task.	Water	202-207	tyrosine hydroxylase	Mus musculus	30-50
11288486-4	2001	The heterozygous mice for the tyrosine hydroxylase (TH) gene and for the cyclic AMP (cAMP) response element binding protein (CREB) binding protein (CBP) gene showed impairment of latent learning in the water finding task.	Water	202-207	tyrosine hydroxylase	Mus musculus	52-54
11235870-3	2001	The treatment eliminates the toxic substances and increases the biodegradability of the treated water (measured as the ratio BOD5/COD).	Water	96-101	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	130-133
11178046-3	2001	These structures include toroidal rings of water around the rotating shaft and water sheaths, which, depending on experimental conditions, can either expand to press against the inner walls of the outer stationary cylinder or contract to hug the outside of the rotating shaft.	Water	43-48	ciliogenesis and planar polarity effector complex subunit 1	Homo sapiens	238-241
11178046-3	2001	These structures include toroidal rings of water around the rotating shaft and water sheaths, which, depending on experimental conditions, can either expand to press against the inner walls of the outer stationary cylinder or contract to hug the outside of the rotating shaft.	Water	79-84	ciliogenesis and planar polarity effector complex subunit 1	Homo sapiens	238-241
11076939-7	2001	These findings show that the extracellular domains of GluR1 that are sufficient for ligand binding apparently are sufficient for subunit assembly and might be a suitable target for structural studies of a water-soluble GluR1 oligomer.	Water	205-210	glutamate receptor, ionotropic, AMPA 1 L homeolog	Xenopus laevis	54-59
11076939-7	2001	These findings show that the extracellular domains of GluR1 that are sufficient for ligand binding apparently are sufficient for subunit assembly and might be a suitable target for structural studies of a water-soluble GluR1 oligomer.	Water	205-210	glutamate receptor, ionotropic, AMPA 1 L homeolog	Xenopus laevis	219-224
11243347-9	2001	For example, FPI-CBCT images of a breast-equivalent insert in water were degraded in CNR by nearly a factor of 2 for SPR ranging from approximately 2% to 120%.	Water	62-67	sepiapterin reductase	Homo sapiens	117-120
11158584-6	2001	S. chevalieri Aqy2p is a functional water channel in oocytes and traffics to the plasma membrane of yeast.	Water	36-41	Aqy2p	Saccharomyces cerevisiae S288C	14-19
11306044-1	2001	Molecular dynamics (MD) simulation of the rat class 3 aldehyde dehydrogenase (ALDH) with nicotinamide dinucleotide (NAD) cofactors and explicit water molecules are reported.	Water	144-149	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	54-76
11306044-1	2001	Molecular dynamics (MD) simulation of the rat class 3 aldehyde dehydrogenase (ALDH) with nicotinamide dinucleotide (NAD) cofactors and explicit water molecules are reported.	Water	144-149	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	78-82
11035042-1	2001	Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes.	Water	16-21	aquaporin 1	Mus musculus	86-90
11035042-1	2001	Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes.	Water	91-96	aquaporin 1	Mus musculus	86-90
11035042-6	2001	Erythrocyte water permeability was 7-fold reduced by AQP1 deletion but not further reduced in AQP1/AQP3 null mice.	Water	12-17	aquaporin 1	Mus musculus	53-57
11484938-2	2001	The resulting water-soluble oligomers were composed of poly[(R,S)-3-hydroxybutanoic acid] (a-PHB) covalently conjugated to L-alanine and Ala-Ala-Ala oligopeptide.	Water	14-19	prohibitin 1	Homo sapiens	93-96
11150020-9	2001	Increased renin in the preglomerular arterioles may activate local angiotensin production, leading to intrarenal vasoconstriction, reduced nephron blood flow, sodium and water retention, and worsening of congestive heart failure.	Water	170-175	renin	Rattus norvegicus	10-15
11464767-5	2001	38% (9/24) raw water and 23% (10/44) tap water samples were positive for at least one virus marker with 9/10 positive tap water samples complying with bacterial criteria.	Water	41-46	tracheal antimicrobial peptide	Bos taurus	37-40
12579850-9	2001	Rg1 (5, 10 mg.kg-1) decreased the latencies and swim distances of mice to reach a hidden platform and improved the corresponding changes in search strategies occurred in the Morris water maze, and Rg1 (10 mg.kg-1, i.p.	Water	181-186	protein phosphatase 1, regulatory subunit 3A	Mus musculus	0-3
11134591-7	2000	Leptin effect on dependable variables such as food intake, water intake and body weight gain was also investigated.	Water	59-64	leptin	Rattus norvegicus	0-6
11134591-10	2000	Leptin significantly inhibited food intake, water intake and gain in body weight during recommenced feeding.	Water	44-49	leptin	Rattus norvegicus	0-6
10407150-5	1999	(1)H-NMR spectroscopy reveals that in the betaA3/betaB2-crystallin tetramer, the N-terminal extensions of betaA3-crystallin remain water-exposed and flexible, whereas both N- and C-terminal extensions of betaB2-crystallin lose their flexibility.	Water	131-136	crystallin beta B2	Homo sapiens	49-66
10476059-3	1999	(i) In the absence of water stress, a 70-80% decrease in SPS activity led to a 30-50% inhibition of sucrose synthesis and a slight (10-20%) increase of starch synthesis in tuber discs in short-term labelling experiments with low concentrations of labelled glucose.	Water	22-27	probable sucrose-phosphate synthase	Solanum tuberosum	57-60
10366670-3	1999	Phosphorylation of the Ca2+-ATPase by ATP required the presence of both water and Ca2+ in the micelles.	Water	72-77	dynein axonemal heavy chain 8	Homo sapiens	28-34
10366670-10	1999	These results suggest that: (1) the rate of conversion of the ATPase conformer E2 into E1 is greatly reduced at low water content, so that E2--&gt;E1 becomes the rate-limiting step of the catalytic cycle; and (2) in media of low water content, Pi can phosphorylate both E1Ca and E2.	Water	116-121	dynein axonemal heavy chain 8	Homo sapiens	62-68
10366670-10	1999	These results suggest that: (1) the rate of conversion of the ATPase conformer E2 into E1 is greatly reduced at low water content, so that E2--&gt;E1 becomes the rate-limiting step of the catalytic cycle; and (2) in media of low water content, Pi can phosphorylate both E1Ca and E2.	Water	229-234	dynein axonemal heavy chain 8	Homo sapiens	62-68
10397974-4	1999	The states of water in the hydrogels were determined by DSC.	Water	14-19	desmocollin 3	Homo sapiens	56-59
10339545-1	1999	Atrial natriuretic peptide (ANP) and nitric oxide (NO) are key regulators of ion and water transport in the kidney.	Water	85-90	natriuretic peptides A	Oryctolagus cuniculus	0-26
10339545-1	1999	Atrial natriuretic peptide (ANP) and nitric oxide (NO) are key regulators of ion and water transport in the kidney.	Water	85-90	natriuretic peptides A	Oryctolagus cuniculus	28-31
10419292-1	1999	Application of a modified ePHOGSY and other NMR experiments to an H2O-DMSO solution of the protein FKBP12 identified the presence of one molecule of DMSO bound in the substrate binding site.	Water	66-69	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	99-105
10392657-5	1999	It can first be demonstrated 72 h postnatally when an intracerebroventricular injection of renin elicits greater swallowing of NaCl solution than water and greater mouthing of solid fragments of NaCl than of an artificial sweetener.	Water	146-151	renin	Rattus norvegicus	91-96
10092461-1	1999	A key feature of the generally accepted catalytic mechanism of CuZn superoxide dismutase (CuZnSOD) is the breakage of the imidazolate bridge between copper and zinc and the loss of a coordinated water molecule from copper on reduction from Cu(II) to Cu(I).	Water	195-200	superoxide dismutase [Cu-Zn]	Bos taurus	63-88
10092461-1	1999	A key feature of the generally accepted catalytic mechanism of CuZn superoxide dismutase (CuZnSOD) is the breakage of the imidazolate bridge between copper and zinc and the loss of a coordinated water molecule from copper on reduction from Cu(II) to Cu(I).	Water	195-200	superoxide dismutase [Cu-Zn]	Bos taurus	90-97
10198408-1	1999	Aquaporin 1 (AQP-1) is a water channel protein that is constitutively expressed in renal proximal tubule and descending thin limb cells as well as in endothelial cells of the descending vasa recta.	Water	25-30	aquaporin 1	Rattus norvegicus	0-11
10198408-1	1999	Aquaporin 1 (AQP-1) is a water channel protein that is constitutively expressed in renal proximal tubule and descending thin limb cells as well as in endothelial cells of the descending vasa recta.	Water	25-30	aquaporin 1	Rattus norvegicus	13-18
11078688-14	2000	These results indicate rapid osmotic equilibration across the pleural surface that is facilitated by AQP1 water channels.	Water	106-111	aquaporin 1	Mus musculus	101-105
19590806-5	2009	The ENVI-Carb column recovered 87.99%-95.95% of the diazinon from water and soil with CVs of 5.08%-8.06%.	Water	66-71	syntaxin 8	Homo sapiens	9-13
11080067-3	2000	Although water bathing, in which muscle activity was slight, was sufficiently stressful to produce gastric hemorrhage and to increase gastric HDC activity, it produced no detectable elevation of HDC activity in any of the muscles examined.	Water	9-14	histidine decarboxylase	Mus musculus	142-145
19924955-7	2009	Moreover, HPLC-ICP-MS analysis of hot boiling water eluted traps showed that the corresponding oxy ions of the arsines were formed with the As-C bonds of the molecule intact, hence, allowing qualification of trapped arsine species.	Water	46-51	steroid sulfatase	Bos taurus	140-144
11112997-9	2000	In cTnI null mice made hypothyroid by addition of phenylthiouracil to the drinking water, ssTnI expression was prolonged and mice survived until day 20 or 21.	Water	83-88	troponin I, cardiac 3	Mus musculus	3-7
11152294-7	2000	The lowest-energy conformations in the presence and absence of water had beta-turns at residues Phe3-Gln4 and Gln4-Asn5 and Gln4-Asn5, respectively.	Water	63-68	dihydrolipoamide dehydrogenase	Homo sapiens	96-100
19596320-2	2009	Retinal content and immunolocalization of two water channels, AQP1 and AQP4, in the diabetic rat retinas during high-salt loading were examined in this study.	Water	46-51	aquaporin 1	Rattus norvegicus	62-66
11093802-1	2000	The human UDP-glucuronosyltransferase isoform UGT1A6 catalyzes the nucleophilic attack of phenolic xenobiotics on glucuronic acid, leading to the formation of water-soluble glucuronides.	Water	159-164	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	46-52
20376224-15	2009	The proposed formula for assay on anhydrous basis= (assay on as-is basisxPhi)/(Phi-%water) in which Phi is sum of experimental results of assay and water content tests experimentally determined, separately, on as-is basis.	Water	84-89	glucose-6-phosphate isomerase	Homo sapiens	79-82
11014933-3	2000	After 24-hour water deprivation, Clcnk1-/- mice became severely dehydrated and lethargic.	Water	14-19	chloride channel, voltage-sensitive Ka	Mus musculus	33-39
20376224-15	2009	The proposed formula for assay on anhydrous basis= (assay on as-is basisxPhi)/(Phi-%water) in which Phi is sum of experimental results of assay and water content tests experimentally determined, separately, on as-is basis.	Water	148-153	glucose-6-phosphate isomerase	Homo sapiens	79-82
19724054-0	2009	The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume.	Water	4-9	aquaporin 1	Mus musculus	18-29
11087470-7	2000	k(w2), the slope of the second linear segment of the TGA curve, was related to the loss of water due to nonenzymatic browning (NEB).	Water	91-96	T-box transcription factor 1	Homo sapiens	53-56
19724054-1	2009	Aquaporin-1 (AQP-1), the universal water channel, is responsible for rapid response of cell volume to changes in plasma tonicity.	Water	35-40	aquaporin 1	Mus musculus	0-11
11032908-6	2000	A selective inhibitor of cyclooxygenase-2, SC 58125, prevented depletion of ascorbate and thiols, the two major water-soluble antioxidants in traumatized brain.	Water	112-117	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	25-41
19724054-1	2009	Aquaporin-1 (AQP-1), the universal water channel, is responsible for rapid response of cell volume to changes in plasma tonicity.	Water	35-40	aquaporin 1	Mus musculus	13-18
19397935-6	2009	Significant decreases in water and food intake were seen in female NPY-/- as well as male and female PYY+NPY-/- mice during the photophase.	Water	25-30	neuropeptide Y	Mus musculus	67-70
11092324-0	2000	Characterization of the contribution of water activity and moisture content to the population distribution of Salmonella spp.	Water	40-45	histocompatibility minor 13	Homo sapiens	121-124
19397935-6	2009	Significant decreases in water and food intake were seen in female NPY-/- as well as male and female PYY+NPY-/- mice during the photophase.	Water	25-30	neuropeptide Y	Mus musculus	105-108
19640876-2	2009	The availability of both hydrogenated and perdeuterated samples of maltose-binding protein (MBP) allowed us to directly measure with great accuracy the signal from the protein and the hydration water alone.	Water	194-199	myelin basic protein	Homo sapiens	67-90
11015197-1	2000	The binding site of the dopamine D2 receptor, like that of homologous G-protein-coupled receptors (GPCRs), is contained within a water-accessible crevice formed among its seven transmembrane segments (TMSs).	Water	129-134	dopamine receptor D2	Homo sapiens	24-44
19640876-2	2009	The availability of both hydrogenated and perdeuterated samples of maltose-binding protein (MBP) allowed us to directly measure with great accuracy the signal from the protein and the hydration water alone.	Water	194-199	myelin basic protein	Homo sapiens	92-95
11093712-7	2000	Analysis of the data by the VTF equation yields the result that at a given concentration the self diffusion coefficients of the sugar Dc and the viscosity eta are described by identical ideal glass transition temperatures T0, while the diffusion of the water D(W) molecule decouples from these properties.	Water	253-258	endothelin receptor type A	Homo sapiens	155-158
11032857-4	2000	In response to water deprivation, COX2, but not COX1, mRNA levels increase significantly in the renal medulla, specifically in renal medullary interstitial cells (RMICs).	Water	15-20	cytochrome c oxidase II, mitochondrial	Mus musculus	34-38
19640876-5	2009	In MBP and its hydration water, the two relaxations take place with similar average characteristic times of approximately 10 and 0.2 ps.	Water	25-30	myelin basic protein	Homo sapiens	3-6
11198854-4	2000	The data analysis from EXAFS and LAXS measurements of the aqueous solution resulted in the La-O bond distances 2.52(2) and 2.65(3) A to the water molecules in the prism and the capping positions, respectively.	Water	140-145	interleukin 4 induced 1	Homo sapiens	91-95
19309260-10	2009	Exogenous H(2)O(2) or transfection of a NOX1 plasmid restored AngII responses in NOX1-deficient cells.	Water	10-15	NADPH oxidase 1	Mus musculus	81-85
10925260-9	2000	Upon stimulation with dendritic cells in the presence of the water-soluble DNFB analogue, DNBS, CTLA-4+ T cells from DNFB-tolerized mice secreted high levels of IL-10, TGF-beta, and IFN-gamma; low levels of IL-2; and no IL-4, resembling the cytokine pattern of T regulatory 1 cells.	Water	61-66	transforming growth factor, beta 1	Mus musculus	168-176
19545558-5	2009	The subzero water transport response is analyzed to determine the variables governing the rate of water loss during cooling of bovine spermatozoa, i.e. the membrane permeability parameters (reference membrane permeability, L(pg) and activation energy, E(Lp)).	Water	12-17	colostrum trypsin inhibitor	Bos taurus	252-257
10818094-1	2000	We have shown that gelsolin is one of the most prevalent water-soluble proteins in the transparent cornea of zebrafish.	Water	57-62	gelsolin a	Danio rerio	19-27
19628672-2	2009	We hypothesized that osmotically induced renin release depends on water movement through aquaporin-1 (AQP1) water channels and subsequent prostanoid formation.	Water	66-71	aquaporin 1	Mus musculus	89-100
10924349-2	2000	We demonstrate that in vitro the Na(+)/K(+)-ATPase, a non heme-protein, is able to disproportionate H(2)O(2) catalatically into dioxygen and water, as well as C(40) catalase.	Water	141-146	dynein axonemal heavy chain 8	Homo sapiens	44-50
10698532-2	1999	Investigation using deuterium-labeled oxycodone and analysis by LC/MS showed that gem diol and hemiketal adducts of oxycodone formed as a result of the equilibrium addition of water and methanol to the C-6 ketone on oxycodone.	Water	176-181	complement C6	Homo sapiens	202-205
19628672-2	2009	We hypothesized that osmotically induced renin release depends on water movement through aquaporin-1 (AQP1) water channels and subsequent prostanoid formation.	Water	66-71	aquaporin 1	Mus musculus	102-106
10084306-8	1999	Finally, occlusion with a water-impermeable membrane prevented both the air-exposure-induced increase in lipid enzyme activity, and the expression of loricrin, filaggrin, and involucrin.	Water	26-31	loricrin cornified envelope precursor protein	Rattus norvegicus	150-158
10930316-3	2000	In the present study, we evaluated EAU induction in GKO mice by the newly described H-2(b)epitope contained in residues 1-20 of human IRBP, and compared it to the response to the whole IRBP molecule.	Water	35-38	retinol binding protein 3	Homo sapiens	134-138
19628672-2	2009	We hypothesized that osmotically induced renin release depends on water movement through aquaporin-1 (AQP1) water channels and subsequent prostanoid formation.	Water	108-113	aquaporin 1	Mus musculus	89-100
19628672-2	2009	We hypothesized that osmotically induced renin release depends on water movement through aquaporin-1 (AQP1) water channels and subsequent prostanoid formation.	Water	108-113	aquaporin 1	Mus musculus	102-106
19628672-10	2009	Taken together, our results show that a 5 to 7% decrease in extracellular tonicity leads to AQP1-mediated water influx in JG cells, PLA(2)/COX-2-mediated prostaglandin-dependent formation of cAMP, and activation of PKA, which promotes exocytosis of renin.	Water	106-111	aquaporin 1	Mus musculus	92-96
10970094-3	2000	Examination of H2-O expression in freshly isolated mouse organs revealed that H2-Oa- and H2-Ob-specific transcripts are present in both lymphoid and nonlymphoid tissues.	Water	15-19	histocompatibility 2, O region beta locus	Mus musculus	89-94
19321879-12	2009	Thus, anionic lipids present within lipid membranes enhance the rate of phospholipid hydrolysis by LPLA2 at lipid-water interfaces.	Water	114-119	phospholipase A2, group XV	Mus musculus	99-104
10882485-4	2000	For the water-air-nanospheres system, n-propanol at various concentrations in water was used to aid in dispersing the nanospheres, and the enthalpy of immersion between water, air, and nanospheres was obtained by extraploting to zero n-propanol concentration.	Water	8-13	activation induced cytidine deaminase	Homo sapiens	96-99
10882485-4	2000	For the water-air-nanospheres system, n-propanol at various concentrations in water was used to aid in dispersing the nanospheres, and the enthalpy of immersion between water, air, and nanospheres was obtained by extraploting to zero n-propanol concentration.	Water	78-83	activation induced cytidine deaminase	Homo sapiens	96-99
10882485-4	2000	For the water-air-nanospheres system, n-propanol at various concentrations in water was used to aid in dispersing the nanospheres, and the enthalpy of immersion between water, air, and nanospheres was obtained by extraploting to zero n-propanol concentration.	Water	78-83	activation induced cytidine deaminase	Homo sapiens	96-99
19756840-5	2009	Phylogenetic analysis indicated that lineage-specific gene expansion and duplication may be the important forces driving the variability of ABC systems in fresh-water Synechococcus and such an expansion was likely to be relevant to their ecological tolerance.	Water	161-166	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	140-143
10898713-7	2000	H(2)O(2) mediates changes in ERK1/ERK2 phosphorylation, increases endothelial solute permeability, and alters occludin localization and phosphorylation were all blocked by PD-98059, a specific mitogen-activated protein (MAP) or ERK kinase 1 inhibitor.	Water	0-5	occludin	Homo sapiens	110-118
10852710-3	2000	Two new water molecules in Q143A MnSOD were situated in positions nearly identical with the Oepsilon1 and Nepsilon2 of the replaced Gln 143 side chain and maintained a hydrogen-bonded network connecting the manganese-bound solvent molecule to other residues in the active site.	Water	8-13	superoxide dismutase 2	Homo sapiens	33-38
10871048-3	2000	Incubations of the yeast DHOD with dideuterodihydroorotate (deuterated in the positions eliminated in the dehydrogenation) as the donor and [14C]orotate as the acceptor revealed that the C5 deuteron exchanged with H2O solvent at a rate equal to the 14C exchange rate, whereas the C6 deuteron was infrequently exchanged with H2O solvent, thus indicating that the C6 deuteron of the dihydroorotate is sticky on the flavin cofactor.	Water	214-217	dihydroorotate dehydrogenase	Saccharomyces cerevisiae S288C	25-29
10871048-3	2000	Incubations of the yeast DHOD with dideuterodihydroorotate (deuterated in the positions eliminated in the dehydrogenation) as the donor and [14C]orotate as the acceptor revealed that the C5 deuteron exchanged with H2O solvent at a rate equal to the 14C exchange rate, whereas the C6 deuteron was infrequently exchanged with H2O solvent, thus indicating that the C6 deuteron of the dihydroorotate is sticky on the flavin cofactor.	Water	324-327	dihydroorotate dehydrogenase	Saccharomyces cerevisiae S288C	25-29
10827157-2	2000	Because AQP1 is present on the basolateral cholangiocyte membrane in low amounts, we hypothesized that another AQP must be expressed at this domain to facilitate transbasolateral water movement.	Water	179-184	aquaporin 1	Rattus norvegicus	8-12
15348019-12	2000	The results of DTA/TGA indicated that loss of water and organic materials occurred in both enamel and dentin after laser treatment.	Water	46-51	T-box transcription factor 1	Homo sapiens	19-22
10799482-4	2000	We also found that human islet amylin and the prion protein fragment (PrP106-126), peptides that acquire beta-pleated sheet conformation in water solutions and have been reported to form ion channels across planar bilayer membranes, also increase cytosolic free calcium in GT1-7 neurons.	Water	140-145	islet amyloid polypeptide	Homo sapiens	31-37
10815515-2	2000	The symptoms are caused by lowered activity of uroporphyrinogen decarboxylase (URO-D) resulting in accumulation of water-soluble porphyrins in the skin.	Water	115-120	uroporphyrinogen decarboxylase	Homo sapiens	47-77
10815515-2	2000	The symptoms are caused by lowered activity of uroporphyrinogen decarboxylase (URO-D) resulting in accumulation of water-soluble porphyrins in the skin.	Water	115-120	uroporphyrinogen decarboxylase	Homo sapiens	79-84
10751223-2	2000	Studies in Sprague-Dawley rats showed that restriction of water intake for 3 days results in upregulation of urea transporter (UT) mRNA in the inner stripe of outer medulla of the kidney (2.9-kb UT2) but not in the inner medulla (4.0-kb UT1).	Water	58-63	cytochrome P450, family 2, subfamily c, polypeptide 12	Rattus norvegicus	237-240
10751223-7	2000	Our studies reveal the role of vasopressin in long-term regulation of UT1 and UT2 expression during water restriction.	Water	100-105	cytochrome P450, family 2, subfamily c, polypeptide 12	Rattus norvegicus	70-73
10750022-4	2000	A non-radioactive in situ hybridization procedure has allowed us to detect the expression of the tilapia PRL-R in the branchial chloride cells and the intestinal mucosal layer of fresh water animals, confirming the direct control exerted by prolactin on the water and ionic exchanges in tilapia.	Water	185-190	prolactin receptor	Oreochromis niloticus	105-110
10750022-4	2000	A non-radioactive in situ hybridization procedure has allowed us to detect the expression of the tilapia PRL-R in the branchial chloride cells and the intestinal mucosal layer of fresh water animals, confirming the direct control exerted by prolactin on the water and ionic exchanges in tilapia.	Water	258-263	prolactin receptor	Oreochromis niloticus	105-110
10751725-9	2000	A lower catalytic activity of enzymes such as Cu/Zn superoxide dismutase (Cu/Zn-SOD) and cytochrome-c oxidase could increase the intracellular production of active oxygen species (O(2)(-), H(2)O(2) and OH(o)) with the consequent clastogenic effects.	Water	189-194	superoxide dismutase [Cu-Zn]	Bos taurus	46-72
10751725-9	2000	A lower catalytic activity of enzymes such as Cu/Zn superoxide dismutase (Cu/Zn-SOD) and cytochrome-c oxidase could increase the intracellular production of active oxygen species (O(2)(-), H(2)O(2) and OH(o)) with the consequent clastogenic effects.	Water	189-194	superoxide dismutase [Cu-Zn]	Bos taurus	74-83
10751725-9	2000	A lower catalytic activity of enzymes such as Cu/Zn superoxide dismutase (Cu/Zn-SOD) and cytochrome-c oxidase could increase the intracellular production of active oxygen species (O(2)(-), H(2)O(2) and OH(o)) with the consequent clastogenic effects.	Water	189-194	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	89-109
10710377-1	2000	Aquaporin-1 (AQP1) is a water channel expressed abundantly at the apical pole of choroidal epithelial cells.	Water	24-29	aquaporin 1	Rattus norvegicus	0-11
10710377-1	2000	Aquaporin-1 (AQP1) is a water channel expressed abundantly at the apical pole of choroidal epithelial cells.	Water	24-29	aquaporin 1	Rattus norvegicus	13-17
10662522-1	2000	Hydrophobic helical peptide molecules with a lactose unit at the C terminal, Nap-(Ala-Aib)(n)-NHCH(2)CH(2)NH-Lac (Nap, Aib, and Lac represent 2-naphthylacetic acid group, 2-aminoisobutyric acid, and lactobionic acid group, respectively, n=4, 6, 8), were synthesized and their formation of self-assemblies in water was investigated.	Water	308-313	lactase	Homo sapiens	109-112
10662732-10	2000	These results indicate that ET(B) receptors in the renal medulla are up-regulated in the DOCA-salt hypertensive rat and may serve to maintain a lower arterial pressure by promoting salt and water excretion.	Water	190-195	endothelin receptor type B	Rattus norvegicus	28-33
10716181-4	2000	By contrast, the protection of amide protons from strand beta5 is too weak to measure in water.	Water	89-94	tubulin beta 4A class IVa	Homo sapiens	57-62
10644730-12	2000	These results provide direct evidence against physiologically significant AQP1-mediated CO(2) transport and establish an upper limit to the CO(2) permeability through single AQP1 water channels.	Water	179-184	aquaporin 1	Mus musculus	174-178
10633273-6	2000	Water immersion caused a remarkable decrease in serum calcitonin concentration as early as at 30 min.	Water	0-5	calcitonin-related polypeptide alpha	Rattus norvegicus	54-64
10613915-6	2000	Transcapillary osmotic water permeability was greatly reduced by AQP1 deletion, as measured by the same method except that the airspace saline was replaced by an inert perfluorocarbon.	Water	23-28	aquaporin 1	Mus musculus	65-69
10683568-7	2000	In the first experiment, there were significant correlations between water maze performance and the number of; (i) choline acetyltransferase- and p75(NTR)-positive neurons in the nucleus basalis magnocellularis; (ii) choline acetyltransferase-positive neurons in the striatum and; (iii) p75(NTR)-positive neurons in the medial septum.	Water	69-74	nerve growth factor receptor	Rattus norvegicus	146-149
10683568-7	2000	In the first experiment, there were significant correlations between water maze performance and the number of; (i) choline acetyltransferase- and p75(NTR)-positive neurons in the nucleus basalis magnocellularis; (ii) choline acetyltransferase-positive neurons in the striatum and; (iii) p75(NTR)-positive neurons in the medial septum.	Water	69-74	nerve growth factor receptor	Rattus norvegicus	287-290
11114031-2	2000	This produced water contains residues of oilfield chemicals added by the platform operators to the topside processing equipment to aid oil-water separation and mitigate operational problems.	Water	14-19	activation induced cytidine deaminase	Homo sapiens	131-134
11114031-2	2000	This produced water contains residues of oilfield chemicals added by the platform operators to the topside processing equipment to aid oil-water separation and mitigate operational problems.	Water	139-144	activation induced cytidine deaminase	Homo sapiens	131-134
10611376-1	1999	Production of prostaglandins involved in renal salt and water homeostasis is modulated by regulated expression of the inducible form of cyclooxygenase-2 (COX-2) at restricted sites in the rat renal cortex.	Water	56-61	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	136-152
10611376-1	1999	Production of prostaglandins involved in renal salt and water homeostasis is modulated by regulated expression of the inducible form of cyclooxygenase-2 (COX-2) at restricted sites in the rat renal cortex.	Water	56-61	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	154-159
10746170-11	1999	The character of the membrane-water interface region in the liposome controls a triggering effect for P-9-mediated fusion.	Water	30-35	exosome component 8	Homo sapiens	102-105
10682248-20	1999	The difference of 3.66 x 10(-6) (33.5%) heartbeats can be attributed to either the more advanced stage of the PSP hatchlings at hatch, to the larger mE values of these hatchlings, to the difference in water fraction of the hatchlings or all.	Water	201-206	BPI fold containing family A member 2	Homo sapiens	110-113
10619188-8	1999	(2) Pth increased the water content in lung parenchyma samples, but not in trachea or bronchi, and augmented the respiratory secretions measured through monosaccharide content in bronchoalveolar lavage.	Water	22-27	LOW QUALITY PROTEIN: parathyroid hormone	Cavia porcellus	4-7
10355303-6	1999	Significant associations were also observed between: (i) the sources of drinking water and deaths due to ARI, and (ii) conditions of latrines and deaths due to diarrhoeal diseases, after controlling for the confounding variables.	Water	81-86	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	105-108
10021457-9	1999	These results demonstrate that AQP1 is the principal water channel in TDLH and support the view that osmotic equilibration along TDLH by water transport plays a key role in the renal countercurrent concentrating mechanism.	Water	53-58	aquaporin 1	Mus musculus	31-35
10021457-9	1999	These results demonstrate that AQP1 is the principal water channel in TDLH and support the view that osmotic equilibration along TDLH by water transport plays a key role in the renal countercurrent concentrating mechanism.	Water	137-142	aquaporin 1	Mus musculus	31-35
10021464-1	1999	The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia.	Water	29-34	aquaporin 1	Mus musculus	43-54
10021464-5	1999	Microvascular endothelial water permeability, measured by a related pleural surface fluorescence method in which the airspace was filled with inert perfluorocarbon, was reduced more than 10-fold in AQP1 (-/-) vs. (+/+) mice.	Water	26-31	aquaporin 1	Mus musculus	198-202
10021464-7	1999	Both approaches indicated a more than twofold reduction in lung water accumulation in AQP1 (-/-) vs. (+/+) mice in response to a 5- to 10-cm H2O increase in pulmonary artery pressure for five minutes.	Water	64-69	aquaporin 1	Mus musculus	86-90
10021464-7	1999	Both approaches indicated a more than twofold reduction in lung water accumulation in AQP1 (-/-) vs. (+/+) mice in response to a 5- to 10-cm H2O increase in pulmonary artery pressure for five minutes.	Water	141-144	aquaporin 1	Mus musculus	86-90
10021464-10	1999	These results indicate that osmotically driven water transport across microvessels in adult lung occurs by a transcellular route through AQP1 water channels and that the microvascular endothelium is a significant barrier for airspace-capillary osmotic water transport.	Water	47-52	aquaporin 1	Mus musculus	137-141
10021464-10	1999	These results indicate that osmotically driven water transport across microvessels in adult lung occurs by a transcellular route through AQP1 water channels and that the microvascular endothelium is a significant barrier for airspace-capillary osmotic water transport.	Water	142-147	aquaporin 1	Mus musculus	137-141
10021464-10	1999	These results indicate that osmotically driven water transport across microvessels in adult lung occurs by a transcellular route through AQP1 water channels and that the microvascular endothelium is a significant barrier for airspace-capillary osmotic water transport.	Water	142-147	aquaporin 1	Mus musculus	137-141
10682062-0	1999	Water channel AQP-1 in the primary cell culture of rat peritoneum.	Water	0-5	aquaporin 1	Rattus norvegicus	14-19
9887005-1	1999	Aquaporin-1 (AQP1) water channels are present in the apical and basolateral plasma membrane domains of bile duct epithelial cells, or cholangiocytes, and mediate the transport of water in these cells.	Water	19-24	aquaporin 1	Rattus norvegicus	0-11
9887005-1	1999	Aquaporin-1 (AQP1) water channels are present in the apical and basolateral plasma membrane domains of bile duct epithelial cells, or cholangiocytes, and mediate the transport of water in these cells.	Water	19-24	aquaporin 1	Rattus norvegicus	13-17
9887005-1	1999	Aquaporin-1 (AQP1) water channels are present in the apical and basolateral plasma membrane domains of bile duct epithelial cells, or cholangiocytes, and mediate the transport of water in these cells.	Water	179-184	aquaporin 1	Rattus norvegicus	0-11
9887005-1	1999	Aquaporin-1 (AQP1) water channels are present in the apical and basolateral plasma membrane domains of bile duct epithelial cells, or cholangiocytes, and mediate the transport of water in these cells.	Water	179-184	aquaporin 1	Rattus norvegicus	13-17
19668240-13	2009	This study shows that administration of a physiological concentration of milk OPN in drinking water ameliorates the destructive host response in DSS-induced acute colitis.	Water	94-99	secreted phosphoprotein 1	Mus musculus	78-81
9872856-10	1999	However, spontaneous Pdi was only 1 to 2 cm H2O (&lt; 20% of Pdimax) despite profound hypercapnia.	Water	44-47	prolyl 4-hydroxylase subunit beta	Homo sapiens	21-24
9874700-6	1999	CsA gave many new peaks in the 1H NMR spectrum when the solvent was changed from chloroform to methanol/water, suggesting conformational diversity of CsA in polar solvents.	Water	104-109	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	0-3
9874700-6	1999	CsA gave many new peaks in the 1H NMR spectrum when the solvent was changed from chloroform to methanol/water, suggesting conformational diversity of CsA in polar solvents.	Water	104-109	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	150-153
19376232-1	2009	The secreted phospholipases A2 (sPLA2s) are water-soluble enzymes that bind to the surface of both artificial and biological lipid bilayers and hydrolyze the membrane phospholipids.	Water	44-49	phospholipase A2 group IID	Homo sapiens	32-38
9790175-4	1998	Water intake was reduced by leptin treatment only in young animals (P&lt; 0.001).	Water	0-5	leptin	Rattus norvegicus	28-34
19592295-2	2009	TGA data suggested presence of coordinated and the lattice water.	Water	59-64	T-box transcription factor 1	Homo sapiens	0-3
9765153-6	1998	Moreover, era1 plants exhibited a reduction in transpirational water loss during drought treatment.	Water	63-68	Prenyltransferase family protein	Arabidopsis thaliana	10-14
19806756-6	2009	Proof-of-concept experiments for this approach, using what we call a microbial desalination cell (MDC), was demonstrated using water at different initial salt concentrations (5, 20, and 35 g/L) with acetate used as the substrate for the bacteria.	Water	127-132	C-C motif chemokine ligand 22	Homo sapiens	98-101
9792416-1	1998	Aquaporin 2 (AQP2) transfected into LLC-PK1 cells functions as a vasopressin-regulated water channel that recycles between intracellular vesicles and the plasma membrane upon vasopressin stimulation.	Water	87-92	aquaporin 2	Sus scrofa	0-11
9792416-1	1998	Aquaporin 2 (AQP2) transfected into LLC-PK1 cells functions as a vasopressin-regulated water channel that recycles between intracellular vesicles and the plasma membrane upon vasopressin stimulation.	Water	87-92	aquaporin 2	Sus scrofa	13-17
19789157-7	2009	In contact with sea water only 0.29 mg kg-1 of V, 0.04 mg kg-1 of Cr, 0.07 mg kg-1 of Ni, 0.33 mg kg-1 of Cu, 0.67 mg kg-1 of Zn and 0.06 mg kg-1 of Pb could be remobilised from sediment material into the water column.	Water	20-25	scheggia	Drosophila melanogaster	16-19
9751776-1	1998	Aquaporin (AQP) water channels are abundant in the brain and spinal cord, where AQP1 and AQP4 are believed to play major roles in water metabolism and osmoregulation.	Water	16-21	aquaporin 1	Rattus norvegicus	80-84
9751776-1	1998	Aquaporin (AQP) water channels are abundant in the brain and spinal cord, where AQP1 and AQP4 are believed to play major roles in water metabolism and osmoregulation.	Water	130-135	aquaporin 1	Rattus norvegicus	80-84
19067418-4	2009	The water monolayer of the colyophilized sucrose/protein samples, as determined by BET analysis of water sorption data, was found to be lower than that expected based on additive contributions of pure protein and pure sucrose.	Water	4-9	delta/notch like EGF repeat containing	Homo sapiens	83-86
19661836-1	2009	PURPOSE: To investigate the influence of the water content in non-ionic hydrogel contact lenses (HCL) on the mRNA levels of human conjunctival mucin genes (MUCs).	Water	45-50	LOC100508689	Homo sapiens	143-148
9689069-1	1998	The Stokes radius characteristics of reduced and carboxamidated ribonuclease A (RCAM RNase) were determined for transfer of this "random coil" protein from water to 1 M concentrations of the naturally occurring protecting osmolytes trimethylamine N-oxide, sarcosine, sucrose, and proline and the nonprotecting osmolyte urea.	Water	156-161	coilin	Homo sapiens	137-142
9688688-13	1998	The data demonstrate that ANG II mediates jejunal sodium and water absorption by an action at the AT2 receptor involving cGMP formation.	Water	61-66	angiotensin II receptor, type 2	Rattus norvegicus	98-101
19008779-12	2009	Neuronal NOS inhibition significantly reduced lung water content and attenuated inflammatory indices such as lung tissue myeloperoxidase activity, IL-6 mRNA, and reactive nitrogen species.	Water	51-56	nitric oxide synthase, brain	Ovis aries	0-12
9745889-6	1998	In the non-coaxially stacking pseudoknot, stem 1 (S1), stem 2 (S2), and the intervening A14 involves unconventional stacking of base pairs coordinated by Na+ and/or bridging water molecules.	Water	174-179	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	88-91
19653574-0	2009	B-type natriuretic peptide after open-water and hyperbaric chamber exposure to 10 msw.	Water	38-43	natriuretic peptide B	Homo sapiens	0-26
9649343-3	1998	The NMRD data show that native RNase A contains at least three water molecules with a mean residence time of 8 ns at 27 degreesC and an activation enthalpy of ca.	Water	63-68	ribonuclease A family member 1, pancreatic	Homo sapiens	31-38
9841525-5	1998	We suggest that 1) in vivo, under near-isotonic conditions, caveolae may alternate frequently between brief open and closed-off states; 2) aquaporin-1-caveolin-3 colocalization may be energy dependent; and 3) while closed off from the interstitium, each caveola transiently functions as an osmometer that experiences, monitors, and reacts to net water flow from or into the subcaveolar cytosol of the myocyte.	Water	346-351	aquaporin 1	Rattus norvegicus	139-150
19298815-5	2009	Osmotic water permeability, as measured by calcein fluorescence quenching, was AQP1-dependent in cultured keratocytes, as was keratocyte migration following a scratch wound.	Water	8-13	aquaporin 1	Mus musculus	79-83
9622132-2	1998	Relative rCBF was assessed with [(15)O]water positron emission tomography during a working memory task, a memory span task, and two perceptual control tasks.	Water	39-44	CCAAT/enhancer binding protein zeta	Rattus norvegicus	9-13
19298815-9	2009	These results implicate AQP1 water permeability as a new determinant of keratocyte migration in cornea.	Water	29-34	aquaporin 1	Mus musculus	24-28
19735174-2	2009	Water extracts of both herbal materials were tested in vitro with a battery of assay models: lipopolysaccharide-induced thromboxane B(2) for cyclooxygenase-1 (COX-1), prostaglandin E(2) for cyclooxygenase-2 (COX-2), the translocation of nuclear factor-kappaB (NF-kappaB), and tumor necrosis factor alpha (TNFalpha) and nitric oxide (NO) production in RAW 264.7 cells.	Water	0-5	prostaglandin-endoperoxide synthase 2	Mus musculus	190-206
9575198-1	1998	We have recently identified AQPcic (for aquaporin cicadella), an insect aquaporin found in the digestive tract of homopteran insects and involved in the elimination of water ingested in excess with the dietary sap (Le Caherec, F., Deschamps, S., Delamarche, C., Pellerin, I., Bonnec, G., Guillam, M. T., Gouranton, J., Thomas, D., and Hubert, J. F. (1996) Eur.	Water	168-173	aquaporin	Xenopus laevis	40-49
9575198-1	1998	We have recently identified AQPcic (for aquaporin cicadella), an insect aquaporin found in the digestive tract of homopteran insects and involved in the elimination of water ingested in excess with the dietary sap (Le Caherec, F., Deschamps, S., Delamarche, C., Pellerin, I., Bonnec, G., Guillam, M. T., Gouranton, J., Thomas, D., and Hubert, J. F. (1996) Eur.	Water	168-173	aquaporin	Xenopus laevis	72-81
9612336-5	1998	Physiological doses of desmopressin reproduced the effects of water deprivation on mRNA and intracellular protein levels, suggesting that pIgR expression may be regulated by a vasopressin-coupled mechanism.	Water	62-67	polymeric immunoglobulin receptor	Rattus norvegicus	138-142
19735174-2	2009	Water extracts of both herbal materials were tested in vitro with a battery of assay models: lipopolysaccharide-induced thromboxane B(2) for cyclooxygenase-1 (COX-1), prostaglandin E(2) for cyclooxygenase-2 (COX-2), the translocation of nuclear factor-kappaB (NF-kappaB), and tumor necrosis factor alpha (TNFalpha) and nitric oxide (NO) production in RAW 264.7 cells.	Water	0-5	cytochrome c oxidase II, mitochondrial	Mus musculus	208-213
19585970-6	2009	The slope of k(e) as a function of T/eta for the adenosyl radical in water is in near quantitative agreement with the slope calculated using a hydrodynamic model and the Stokes-Einstein equation for the diffusion coefficients.	Water	69-74	endothelin receptor type A	Homo sapiens	37-40
19451651-2	2009	A growing body of evidence points to a role for dystroglycan and its interaction with perivascular laminin in the targeting of the dystrophin complex and the water-permeable channel, aquaporin 4 (AQP4), at astrocyte endfeet.	Water	158-163	dystroglycan 1	Homo sapiens	48-60
9573539-6	1998	Inner medullary expression of the descending limb water channel, aquaporin-1, was not significantly altered, pointing to a selective effect on the collecting duct.	Water	50-55	aquaporin 1	Rattus norvegicus	65-76
19429813-4	2009	The intake of water-borne Mg(2+) at all levels greatly attenuated or inhibited the reductions in serum SM and serum PC, activation of LP, DNA fragmentation, and the activation of caspase-3; even very low levels of Mg(2+) in drinking water (i.e., 15 parts.million(-1).day(-1)) were cardio- and vascular protective.	Water	14-19	caspase 3	Rattus norvegicus	179-188
9588195-0	1998	Aquaporin-1: an osmoinducible water channel in cultured mIMCD-3 cells.	Water	30-35	aquaporin 1	Mus musculus	0-11
9588195-7	1998	H2O) had conferred cells an 2.5 to 3-fold increase of AQP-1 expression over those grown in the 406 +/- 2 mOsm/kg.	Water	0-3	aquaporin 1	Mus musculus	54-59
19154466-11	2009	BOO caused an increase in Pdet compared to controls, with a mean (SD) of 25 (7) vs 12 (5) cm H2O.	Water	93-96	Bcl2-like 10	Mus musculus	0-3
9545071-11	1998	Immunoblot analysis showed approximately 1.4 x 10(12) aquaporin-1 water channels/cm2 of capillary surface, which accounted quantitatively for the high Pf.	Water	66-71	aquaporin 1	Mus musculus	54-65
9506966-6	1998	In contrast, in oocytes injected with PGT mRNA, the PG influx permeability coefficient was 90-157 times that of oocytes injected with water.	Water	134-139	solute carrier organic anion transporter family member 2A1	Homo sapiens	38-41
19229592-7	2009	LA, which is a water- and lipid-soluble antioxidant, decreased the protein expression of MnSOD, though mRNA levels and activities remained unchanged.	Water	15-20	superoxide dismutase 2	Homo sapiens	89-94
19268466-2	2009	The expression and immunolocalization of two water channels, AQP1 and AQP4, in the rat retina during experimental high salt loading were investigated in this study.	Water	45-50	aquaporin 1	Rattus norvegicus	61-65
9476861-6	1998	Maximal transdiaphragmatic pressures (Pdi(max)) increased from 80.3 +/- 9.5 (SE) to 110.8 +/- 9.3 cm H2O after surgery (p = 0.03), and the twitch transdiaphragmatic pressure response to phrenic nerve stimulation (Pdi(tw)) increased from 17.2 +/- 2.4 to 25.9 +/- 3.0 cm H2O (p = 0.02); these increases were greater than could be accounted for by a decrease in lung volume.	Water	101-104	prolyl 4-hydroxylase subunit beta	Homo sapiens	38-46
9476861-6	1998	Maximal transdiaphragmatic pressures (Pdi(max)) increased from 80.3 +/- 9.5 (SE) to 110.8 +/- 9.3 cm H2O after surgery (p = 0.03), and the twitch transdiaphragmatic pressure response to phrenic nerve stimulation (Pdi(tw)) increased from 17.2 +/- 2.4 to 25.9 +/- 3.0 cm H2O (p = 0.02); these increases were greater than could be accounted for by a decrease in lung volume.	Water	101-104	prolyl 4-hydroxylase subunit beta	Homo sapiens	38-41
9501468-2	1998	The solubilities of two isomers of those doubly branched beta CDs, 1,2- and 1,3-(G)2-beta CDs, in water were much higher than those of parent non-branched beta CD and mono-branched beta CD, 6-O-alpha-D-glucosyl-beta CD (G-beta CD), while the solubility of another isomer, 1,4-(G)2-beta CD, was significantly lower than these two isomers, though it was higher than that of beta CD.	Water	98-103	CD1c molecule	Homo sapiens	62-93
10613650-2	1999	The activity of bovine LPL was measured by chromogenic assay using a water-soluble chromogenic substrate, p-nitrophenyl butyrate.	Water	69-74	lipoprotein lipase	Bos taurus	23-26
19378975-6	2009	Both simulations indicate the presence of one or two internal water molecules absent in both crystal structures and essential for the stabilization of the binding pocket at the interface between transmembrane helices III, IV, and V. The different interactions arising from the substitution of Tyr308 in beta(2)AR into Phe325 in beta(1)AR induce different conformations of the homologous Asn(6.55) inside the binding pockets of the two receptors, suggesting a possible origin of receptor specificity in agonist binding.	Water	62-67	adrenoceptor beta 1	Homo sapiens	328-337
19422244-4	2009	We performed a 40 ns molecular dynamics simulation of the mGluR2/5HT(2A) heterocomplex constructed around a TM4/TM5 interface and embedded in an explicit phospholipidic bilayer surrounded by water molecules.	Water	191-196	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	58-64
9531722-1	1998	Compounds which can occur as disinfection by-products (DBP"s) in swimming pool water were examined for their mucous membrane irritating potential.	Water	79-84	vitamin D-binding protein	Oryctolagus cuniculus	55-58
9531722-10	1998	Moreover, results obtained using this assay suggest that the mucous membrane irritating potential of swimming pool water is a consequence of the effects and synergistic action of a number of DBP"s in the presence of chlorine.	Water	115-120	vitamin D-binding protein	Oryctolagus cuniculus	191-194
19332547-0	2009	The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies.	Water	4-9	aquaporin 1	Mus musculus	18-29
9435270-11	1998	These results demonstrate regulated transepithelial water permeability in epithelial cells transfected with AQP2.	Water	52-57	aquaporin 2	Sus scrofa	108-112
19385615-1	2009	A regioselective epoxy alcohol cyclization promoted by the combination of neutral water and a tetrahydropyran template was investigated through a series of mechanistic experiments carried out on an epoxy alcohol containing a tetrahydropyran ring (1a) and its carbocyclic congener (1b).	Water	82-87	ring finger protein 1	Homo sapiens	241-249
9648244-6	1998	Moreover, the presence of a 3"-O-sulfate group not only increases the water solubility tremendously, but also protects the substrate from cleavage by exo-beta-galactosidase as the 6"-O-benzyl group in 2 does.	Water	70-75	galactosidase beta 1	Homo sapiens	154-172
19385637-12	2009	The fact is that etaloc&gt;eta (DeltaH#&gt;Eeta) for compact proteins was ascribed previously to electrostatic interactions between surface sites and water rigidifying the hydration layer.	Water	150-155	endothelin receptor type A	Homo sapiens	17-20
19380834-9	2009	Sera from hypochlorite- or hydroxyl radical-treated mice and of patients with diffuse SSc contained high levels of AOPP that triggered endothelial production of H(2)O(2) and fibroblast hyperproliferation.	Water	161-166	peroxiredoxin 5	Mus musculus	115-119
9447595-7	1998	Additionally, AT1 receptor function as measured by agonist-induced water intake, was significantly attenuated in these rats.	Water	67-72	angiotensin II receptor, type 1a	Rattus norvegicus	14-17
9809651-0	1998	Effects of endothelin-3 on water and sodium excretion during extracellular volume expansion.	Water	27-32	endothelin 3	Rattus norvegicus	11-23
19271756-1	2009	It is important to study the interaction between water molecules and a host structure for understanding the adsorption mechanism of metal-organic framework (MOF) materials.	Water	49-54	lysine acetyltransferase 8	Homo sapiens	132-161
10452032-12	1998	Accentuated expression of ETB receptor on tubular epithelial cells may induce renal natriuretic action and reduction of water execretion.	Water	120-125	endothelin receptor type B	Rattus norvegicus	26-29
19271756-2	2009	The evolution of the structure of a flexible Cu-MOF, {[Cu(bpy)(H2O)2(BF4)2](bpy)} (bpy=4,4"-bipyridine), upon dehydration and rehydration was studied by thermogravimetric analysis (TGA), infrared (IR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and water adsorption.	Water	280-285	lysine acetyltransferase 8	Homo sapiens	48-51
9405461-2	1997	In transient transfection assays, an increase in promoter activity, up to 3.8-fold, was observed with osmotic stress (600 mosm/kg H2O) using a luciferase reporter gene construct containing aldose reductase promoter sequence from -1,094 base pair (bp) to +23 bp.	Water	130-133	aldo-keto reductase family 1 member B1	Rattus norvegicus	189-205
19271756-4	2009	More importantly, a unique CO2 "gate adsorption" phenomenon was observed despite the exposure of the Cu-MOF to water.	Water	111-116	lysine acetyltransferase 8	Homo sapiens	104-107
19296655-4	2009	Ultrabithorax self-assembles at the air-water interface into nanoscale fibers, which further associate to form macroscale films, sheets, ropes, and tethered encapsulates.	Water	40-45	Ultrabithorax	Drosophila melanogaster	0-13
18941904-4	2009	These effects of H(2)O(2) were suppressed by pretreatment of the cells with 1 muM of LaCl(3) for 2 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2, JNK and p38 MAPK, but only the last two were associated with the ALP activity.	Water	17-22	mitogen activated protein kinase 3	Rattus norvegicus	157-163
9413988-3	1997	Targeted disruption of the MC5-R produced mice with a severe defect in water repulsion and thermoregulation due to decreased production of sebaceous lipids.	Water	71-76	melanocortin 5 receptor	Mus musculus	27-32
9461349-3	1997	Hence to gain insight into the structure-function relationship of these hormones we have investigated the solution structure of hPTHrP(1-34) in pure water alone and have monitored the effect of adding TFE.	Water	149-154	parathyroid hormone like hormone	Homo sapiens	128-134
18941904-4	2009	These effects of H(2)O(2) were suppressed by pretreatment of the cells with 1 muM of LaCl(3) for 2 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2, JNK and p38 MAPK, but only the last two were associated with the ALP activity.	Water	17-22	mitogen activated protein kinase 14	Rattus norvegicus	173-176
18941904-4	2009	These effects of H(2)O(2) were suppressed by pretreatment of the cells with 1 muM of LaCl(3) for 2 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2, JNK and p38 MAPK, but only the last two were associated with the ALP activity.	Water	17-22	mitogen activated protein kinase 3	Rattus norvegicus	177-181
18941904-4	2009	These effects of H(2)O(2) were suppressed by pretreatment of the cells with 1 muM of LaCl(3) for 2 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2, JNK and p38 MAPK, but only the last two were associated with the ALP activity.	Water	115-120	mitogen activated protein kinase 3	Rattus norvegicus	157-163
18941904-4	2009	These effects of H(2)O(2) were suppressed by pretreatment of the cells with 1 muM of LaCl(3) for 2 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2, JNK and p38 MAPK, but only the last two were associated with the ALP activity.	Water	115-120	mitogen activated protein kinase 14	Rattus norvegicus	173-176
18941904-4	2009	These effects of H(2)O(2) were suppressed by pretreatment of the cells with 1 muM of LaCl(3) for 2 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2, JNK and p38 MAPK, but only the last two were associated with the ALP activity.	Water	115-120	mitogen activated protein kinase 3	Rattus norvegicus	177-181
19452895-5	2009	By increasing the diffusion coefficient in reservoirs (D1 and D3) more than 10 times from the value for air or water (D0), the model was sufficient to approximate the well-mixed condition and, consequently, can be used to model transient diffusion in chamber systems with external mixing devices.	Water	111-116	leiomodin 1	Homo sapiens	55-64
9448235-9	1997	In TF-treated animals, the recovery of protein in BAL fluid (TF group, 1.26 +/- 0.07 mg; Alb group, 1.78 +/- 0.10 mg; P = 0.02) and the water content of the extravascular lung tissue (TF group, 78.5 +/- 1.4%; Alb group, 83.2 +/- 1.3%; P = 0.05) were lower than in Alb-treated animals.	Water	136-141	serotransferrin	Oryctolagus cuniculus	3-5
9409467-7	1997	The following water channels were expressed in the lung, AQP1, 4 and 5.	Water	14-19	aquaporin 1	Rattus norvegicus	57-61
19217682-7	2009	Our results show that the consumption of the coffee preparation resulting from water co-extraction of green and roasted coffee beans produce an increase in the metabolic activity and/or numbers of the Bifidobacterium spp.	Water	79-84	histocompatibility minor 13	Homo sapiens	217-220
9359399-2	1997	We have demonstrated previously that an exposure of mammalian cells to hypo-osmotic stress, either in growth medium (30% growth medium and 70% water) or in binary solution containing sorbitol and water, prominently induced the DNA-binding activity of the heat-shock transcription factor (HSF1) [Huang, Caruccio, Liu and Chen (1995) Biochem.	Water	143-148	heat shock transcription factor 1	Homo sapiens	288-292
9359399-2	1997	We have demonstrated previously that an exposure of mammalian cells to hypo-osmotic stress, either in growth medium (30% growth medium and 70% water) or in binary solution containing sorbitol and water, prominently induced the DNA-binding activity of the heat-shock transcription factor (HSF1) [Huang, Caruccio, Liu and Chen (1995) Biochem.	Water	196-201	heat shock transcription factor 1	Homo sapiens	288-292
19273840-1	2009	The water channel aquaporin 1 (AQP1) and certain Rh-family members are permeable to CO(2) and NH(3).	Water	4-9	aquaporin 1	Rattus norvegicus	31-35
19293637-9	2009	Combined treatment with H(2)O(2) and HGF, resulted in a slightly increased production of HGF compared to no treatment (control).	Water	24-29	hepatocyte growth factor	Homo sapiens	89-92
9351624-7	1997	A PMI threshold of 6 cm H2O detected PTP/min &lt; 125 cm H2O s/min with a sensitivity of 0.89 and a specificity of 0.89.	Water	24-27	protein tyrosine phosphatase receptor type U	Homo sapiens	37-40
9351624-7	1997	A PMI threshold of 6 cm H2O detected PTP/min &lt; 125 cm H2O s/min with a sensitivity of 0.89 and a specificity of 0.89.	Water	57-60	protein tyrosine phosphatase receptor type U	Homo sapiens	37-40
19673129-2	2009	The PyTp and PyTp-DNA complex monolayer films were first formed at air-water interface and then transferred onto silicon substrates by Langmuir-Blodgett (LB) technique.	Water	71-76	TTK protein kinase	Homo sapiens	4-8
19673129-2	2009	The PyTp and PyTp-DNA complex monolayer films were first formed at air-water interface and then transferred onto silicon substrates by Langmuir-Blodgett (LB) technique.	Water	71-76	TTK protein kinase	Homo sapiens	13-17
9305967-0	1997	Modification of the water oxidizing complex in leaves of the dgd1 mutant of Arabidopsis thaliana deficient in the galactolipid digalactosyldiacylglycerol.	Water	20-25	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	61-65
19295156-1	2009	The involvement of matrix metalloproteinase-9 (MMP-9) activities in the development of abnormal water diffusion in the brain after cardiac arrest is not fully understood.	Water	96-101	matrix metallopeptidase 9	Mus musculus	19-45
10544015-1	1999	Based on a PCR mutant enzyme of water-soluble glucose dehydrogenase-harboring pyrroloquinoline quinone as the prosthetic group, PQQGDH-B, a site-directed mutagenesis study was carried out.	Water	32-37	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	46-67
19295156-1	2009	The involvement of matrix metalloproteinase-9 (MMP-9) activities in the development of abnormal water diffusion in the brain after cardiac arrest is not fully understood.	Water	96-101	matrix metallopeptidase 9	Mus musculus	47-52
9331414-10	1997	The lifetimes of pairs C2.C8+ and 5mC1.C7+ are 1 ms and 1 s, respectively, at 15 degrees C. Anomalous exchange properties of the T3 imino proton indicate hydrogen bonding to A6 N7 via a water bridge.	Water	186-191	VPS52 subunit of GARP complex	Homo sapiens	43-48
19291313-12	2009	CAXII expression is restricted to cells involved in secretion and water absorption such as parietal cells of the stomach, acinar cells of the salivary glands and pancreas, epithelium of the large intestine, and renal tubules.	Water	66-71	carbonic anhydrase 12	Homo sapiens	0-5
32159319-1	1997	A fluorescence lifetime-based water sensor was developed, based on a solvent-polarity-sensitive fluorescent metal-ligand compound, dipyrido1[3,2-a:2"",3""-c]phenazine, di[cis-1,2-bis(diphenylphosphino)-ethylene] osmium(II) hexafluorophosphate, [Os(dppz)(dppe)2](PF6)2.	Water	30-35	sperm associated antigen 17	Homo sapiens	262-265
10596356-5	1999	Thus, the use of glu-beta-CD and glu-glu-beta-CD permitted the stable complexation of the drug in water.	Water	98-103	beta-carotene oxygenase 1	Mus musculus	21-28
10596356-5	1999	Thus, the use of glu-beta-CD and glu-glu-beta-CD permitted the stable complexation of the drug in water.	Water	98-103	beta-carotene oxygenase 1	Mus musculus	41-48
10596356-9	1999	Sugar-branched-beta-CD gave a water-soluble and stable complex for dexamethasone and changed the disposition of dexamethasone.	Water	30-35	beta-carotene oxygenase 1	Mus musculus	15-22
19114548-3	2009	Here we showed that a gonococcal catalase (kat) mutant in strain MS11 was more sensitive to H(2)O(2) than mutants in cytochrome c peroxidase (ccp), methionine sulfoxide reductase (msrA), or the metal-binding protein (mntC) of the MntABC transporter.	Water	92-97	thiosulfate sulfurtransferase (rhodanese)-like domain containing 1	Mus musculus	43-46
10523394-9	1999	Ang II dose-dependently increased H(2)O(2) production (E(max)=57.6+/-1.7 nmol/L, pD(2)=7.7+/-0.06) and PLD activation (E(max)=207+/-3.3% of control, pD(2)=7.7+/-0.5).	Water	34-39	angiogenin	Homo sapiens	0-3
9231793-10	1997	Leptin, 10 microg/h, significantly decreased urine osmolality, increased water intake, and reduced renal potassium excretion compared with vehicle-infused rats.	Water	73-78	leptin	Rattus norvegicus	0-6
18704951-2	2009	Previously, we reported results from a molecular dynamics study that suggested that buried water (Wat3) may play a role in modulating the structure of the FK506 binding protein-12 (FKBP12) (Park and Saven, Proteins 2005; 60:450-463).	Water	91-96	FKBP prolyl isomerase 1A	Homo sapiens	155-179
9210511-1	1997	BACKGROUND: The side effects of cyclosporine (CsA)-including nephrotoxicity and abnormal differentiation of thymocytes developing in the thymus-can be decreased or even avoided using targeted conjugates of CsA, where both targeting moiety and drug are bound to water-soluble polymeric carrier based on N-(2-hydroxypropyl) methacrylamide (HPMA).	Water	261-266	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	46-49
9210511-1	1997	BACKGROUND: The side effects of cyclosporine (CsA)-including nephrotoxicity and abnormal differentiation of thymocytes developing in the thymus-can be decreased or even avoided using targeted conjugates of CsA, where both targeting moiety and drug are bound to water-soluble polymeric carrier based on N-(2-hydroxypropyl) methacrylamide (HPMA).	Water	261-266	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	206-209
10569186-1	1999	The sodium-hydrogen exchanger isoform, NHE-3 is essential for the absorption of sodium and water from intestine.	Water	91-96	solute carrier family 9 member A3	Rattus norvegicus	39-44
10458924-3	1999	In this study, we examined the distribution of the aquaporin 1 (AQP1) water channel protein in several types of transplanted tumor.	Water	70-75	aquaporin 1	Rattus norvegicus	51-62
18704951-2	2009	Previously, we reported results from a molecular dynamics study that suggested that buried water (Wat3) may play a role in modulating the structure of the FK506 binding protein-12 (FKBP12) (Park and Saven, Proteins 2005; 60:450-463).	Water	91-96	FKBP prolyl isomerase 1A	Homo sapiens	181-187
10458924-3	1999	In this study, we examined the distribution of the aquaporin 1 (AQP1) water channel protein in several types of transplanted tumor.	Water	70-75	aquaporin 1	Rattus norvegicus	64-68
10458924-11	1999	These results show that the AQP1 water channel is heterogeneously expressed in tumor cells and their vasculature, and that the level of expression is determined not only by the specific cellular origin of the tumor, but also by the location of the tumor in the host animal.	Water	33-38	aquaporin 1	Rattus norvegicus	28-32
18704951-6	2009	The structures of mutant FKBP12 show that the ligand-binding pocket is indeed remodeled as predicted by the substitution at position 60, even though the water molecule does not directly interact with any of the amino acids of the binding pocket.	Water	153-158	FKBP prolyl isomerase 1A	Homo sapiens	25-31
18955122-5	2009	The inclusion of dioclein in beta-CD increased the water solubility 44% compared to free dioclein.	Water	51-56	beta-carotene oxygenase 1	Mus musculus	29-36
11970129-2	1999	The water activity versus solute concentration was measured in three different sets of experiments corresponding to different initial concentrations of Cr3+ ions.	Water	4-9	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	152-155
11970129-8	1999	Second, solute clusters formed in the presence of Cr3+ ions demonstrate complex behavior with respect to binding water molecules: (a) at low and moderate supersaturations, they bind more water molecules than clusters formed in the absence of an impurity; and (b) at high supersaturations, they bind less water molecules than clusters formed in the absence of an impurity.	Water	113-118	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	50-53
11970129-8	1999	Second, solute clusters formed in the presence of Cr3+ ions demonstrate complex behavior with respect to binding water molecules: (a) at low and moderate supersaturations, they bind more water molecules than clusters formed in the absence of an impurity; and (b) at high supersaturations, they bind less water molecules than clusters formed in the absence of an impurity.	Water	187-192	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	50-53
11970129-8	1999	Second, solute clusters formed in the presence of Cr3+ ions demonstrate complex behavior with respect to binding water molecules: (a) at low and moderate supersaturations, they bind more water molecules than clusters formed in the absence of an impurity; and (b) at high supersaturations, they bind less water molecules than clusters formed in the absence of an impurity.	Water	187-192	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	50-53
9186490-4	1997	The high bromination activity was lost on dissolving this compound in water and the solution showed the presence of peroxovanadates (mono and di) and vanadates (V1 and oligomeric V10) in 51V-NMR spectrum.	Water	70-75	immunoglobulin kappa variable 1-5	Homo sapiens	161-182
9188697-0	1997	Differences in water release with DNA binding by ultrabithorax and deformed homeodomains.	Water	15-20	Ultrabithorax	Drosophila melanogaster	49-62
9188697-4	1997	We demonstrate in this study that water activity differentially affects Ubx-HD and Dfd-HD DNA binding affinity.	Water	34-39	Ultrabithorax	Drosophila melanogaster	72-75
18955122-10	2009	The mechanism underling the increase in bioavailability is probably a consequence of a protective effect of beta-CD against in vivo biodegradation by enzymes and possibly increased water solubility.	Water	181-186	beta-carotene oxygenase 1	Mus musculus	108-115
9188697-4	1997	We demonstrate in this study that water activity differentially affects Ubx-HD and Dfd-HD DNA binding affinity.	Water	34-39	Deformed	Drosophila melanogaster	83-86
19032361-0	2009	Anti-allergic effects of PG102, a water-soluble extract prepared from Actinidia arguta, in a murine ovalbumin-induced asthma model.	Water	34-39	interphotoreceptor matrix proteoglycan 2	Mus musculus	25-30
9188697-5	1997	The sensitivity of the protein-DNA binding constant to osmotic pressures generated by neutral solutes was measured, and the formation of the Ubx-HD-DNA complex is associated with significantly greater water release than that of the Dfd-HD-DNA complex.	Water	201-206	Ultrabithorax	Drosophila melanogaster	141-144
18801694-6	2009	The rate constants of PAH degradation increase when the water solubility, the vapour pressure and the Henry"s law constant increase.	Water	56-61	phenylalanine hydroxylase	Homo sapiens	22-25
9188697-7	1997	Experiments with chimeric Ubx-Dfd homeodomains demonstrated that the C-terminal region of the Ubx-HD is the primary determinant for the greater water release associated with DNA binding for this protein.	Water	144-149	Ultrabithorax	Drosophila melanogaster	26-29
9188697-7	1997	Experiments with chimeric Ubx-Dfd homeodomains demonstrated that the C-terminal region of the Ubx-HD is the primary determinant for the greater water release associated with DNA binding for this protein.	Water	144-149	Deformed	Drosophila melanogaster	30-33
9188697-7	1997	Experiments with chimeric Ubx-Dfd homeodomains demonstrated that the C-terminal region of the Ubx-HD is the primary determinant for the greater water release associated with DNA binding for this protein.	Water	144-149	Ultrabithorax	Drosophila melanogaster	94-97
9169447-0	1997	Phosphorylation of serine 256 is required for cAMP-dependent regulatory exocytosis of the aquaporin-2 water channel.	Water	102-107	aquaporin 2	Sus scrofa	90-101
9169447-1	1997	The aquaporin-2 (AQP2) vasopressin water channel is translocated to the apical membrane upon vasopressin stimulation.	Water	35-40	aquaporin 2	Sus scrofa	4-15
9169447-1	1997	The aquaporin-2 (AQP2) vasopressin water channel is translocated to the apical membrane upon vasopressin stimulation.	Water	35-40	aquaporin 2	Sus scrofa	17-21
9149056-5	1997	In the upper alimentary canal, CA VI may neutralize the acid by catalyzing the formation of carbon dioxide and water.	Water	111-116	carbonic anhydrase 6	Homo sapiens	31-36
9135100-10	1997	Our results showing an up-regulation of NR1-containing N-methyl-D-aspartate receptors during dehydration suggest that these receptors are involved in the regulation of body water and may represent an adaptive physiological response following activation of the hypothalamo-neurohypophysial axis.	Water	173-178	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	40-43
9140020-1	1997	This study was designed to determine if the increase in plasma renin activity (PRA) that occurs during water deprivation is mediated by the renal sympathetic nerves or adrenomedullary catecholamine release.	Water	103-108	renin	Rattus norvegicus	63-68
9140020-3	1997	In intact or sham-operated rats, 48 h of water deprivation resulted in at least a threefold increase in PRA and plasma renin concentration (PRC) but no significant change in plasma norepinephrine or epinephrine concentration.	Water	41-46	renin	Rattus norvegicus	119-124
9140020-4	1997	Renal denervation decreased basal PRA, reduced the magnitude of the dehydration-induced PRA increase by 33%, and abolished the renin-suppressing effect of l-propranolol infusion in water-deprived rats.	Water	181-186	renin	Rattus norvegicus	127-132
9106700-2	1997	Previous studies have shown that exogenous administration of intravenous PYY stimulates water and electrolyte absorption in both the small and large intestines.	Water	88-93	peptide YY	Canis lupus familiaris	73-76
9106700-3	1997	The purpose of this study was to examine the effects of intraluminal administration of PYY on colonic absorption of electrolytes and water.	Water	133-138	peptide YY	Canis lupus familiaris	87-90
9106700-8	1997	RESULTS: On intraluminal infusion of PYY, increased absorption of water, sodium, and chloride was observed in the colon.	Water	66-71	peptide YY	Canis lupus familiaris	37-40
9097943-5	1997	Under control conditions (5% CO2), pHi (measured with carboxy SNARF-1) was about 0.3 pH units more alkaline than neutral water at each temperature.	Water	121-126	glucose-6-phosphate isomerase 1	Mus musculus	35-38
9049170-2	1997	In order ot be able to study the routing of Aquaporin-1 and the regulation of Aquaporin-1-mediated transcellular water flow, we stably transfected LLC-PK1 and MDCK-HRS cell lines with an Aquaporin-1 expression construct.	Water	113-118	aquaporin-1	Sus scrofa	78-89
9049170-2	1997	In order ot be able to study the routing of Aquaporin-1 and the regulation of Aquaporin-1-mediated transcellular water flow, we stably transfected LLC-PK1 and MDCK-HRS cell lines with an Aquaporin-1 expression construct.	Water	113-118	aquaporin-1	Sus scrofa	78-89
9264053-0	1997	A protective role for calcitonin gene-related peptide in water-immersion stress-induced gastric ulcers in rats.	Water	57-62	calcitonin-related polypeptide alpha	Rattus norvegicus	22-53
9264053-1	1997	This study investigated the role of endogenous and exogenous calcitonin gene-related peptide (CGRP) in water immersion stress (WIS)-induced gastric ulcers in rats.	Water	103-108	calcitonin-related polypeptide alpha	Rattus norvegicus	61-92
9264053-1	1997	This study investigated the role of endogenous and exogenous calcitonin gene-related peptide (CGRP) in water immersion stress (WIS)-induced gastric ulcers in rats.	Water	103-108	calcitonin-related polypeptide alpha	Rattus norvegicus	94-98
12223672-6	1997	Reduced water potential delayed or prevented radicle emergence but enhanced mannanase activity in the endosperm caps.	Water	8-13	mannan endo-1,4-beta-mannosidase 2	Solanum lycopersicum	76-85
9102163-13	1997	The relevance of the modifications of the fibrinolytic balance of mouse microvascular endothelium in bFGF-induced angiogenesis was validated in vivo by a gelatin-sponge assay in which the plasmin inhibitors tranexamic acid and epsilon-aminocaproic acid given to mice in the drinking water inhibited neovascularization induced by the growth factor.	Water	283-288	fibroblast growth factor 2	Mus musculus	101-105
9070453-11	1997	In contrast to the series of peptides described here, either studies of peptides from the GH region of myoglobin show a marked tendency to populate helical structures (H), nascent helical structures (G), or turn conformations (GH peptide) in water solution.	Water	242-247	myoglobin	Physeter catodon	103-112
9094741-4	1997	For comparison, water residence times at positively and negatively charged sites are obtained from a simulation of a highly charged alpha-helical polypeptide from the protein titin in water.	Water	16-21	titin	Homo sapiens	175-180
9094741-4	1997	For comparison, water residence times at positively and negatively charged sites are obtained from a simulation of a highly charged alpha-helical polypeptide from the protein titin in water.	Water	184-189	titin	Homo sapiens	175-180
9020791-2	1997	This study investigated the effect of cholesterol on the way in which hydrophobic SP-B and SP-C modulated the adsorption of lipid into the air-water interface and their respreading from collapsed phase produced on overcompression of the surface film.	Water	143-148	surfactant protein B	Homo sapiens	82-86
9003188-0	1997	Stereocontrolled syntheses of water-soluble inhibitors of phosphatidylinositol-specific phospholipase C: inhibition enhanced by an interface.	Water	30-35	phospholipase C beta 1	Homo sapiens	58-103
8994636-3	1997	Comparison with the results obtained from relaxation time measurements of the purified enzymes in vitro and from theoretical calculations showed that two of the labeled enzymes, phosphoglycerate kinase and hexokinase, were tumbling in a cytoplasm that had a viscosity approximately twice that of water.	Water	296-301	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	178-201
9088840-7	1997	When subjects ingested water or dextrose/electrolyte solution during exercise, ANP rose by 234% and 431% respectively and BNP rose by 398% and 583% respectively without any significant increase in AVP.	Water	23-28	natriuretic peptide B	Homo sapiens	122-125
8972697-14	1996	(vi) Comparison of the calculated dipoles with those estimated for the crystalline conformation of the [MoNa(H2O)2] and [MoK(H2O)2] complexes reveals that the MoNa may exist in the membrane at its crystal configuration, while the MoK definitely attains a structure having a dipole moment larger than in the crystal.	Water	109-112	GRB2 related adaptor protein 2	Homo sapiens	104-108
8972697-14	1996	(vi) Comparison of the calculated dipoles with those estimated for the crystalline conformation of the [MoNa(H2O)2] and [MoK(H2O)2] complexes reveals that the MoNa may exist in the membrane at its crystal configuration, while the MoK definitely attains a structure having a dipole moment larger than in the crystal.	Water	109-112	GRB2 related adaptor protein 2	Homo sapiens	159-163
8972697-14	1996	(vi) Comparison of the calculated dipoles with those estimated for the crystalline conformation of the [MoNa(H2O)2] and [MoK(H2O)2] complexes reveals that the MoNa may exist in the membrane at its crystal configuration, while the MoK definitely attains a structure having a dipole moment larger than in the crystal.	Water	125-128	GRB2 related adaptor protein 2	Homo sapiens	159-163
8912741-6	1996	During acute-on-chronic hyperinflation there was a linear negative correlation of Tw Pdi with increasing lung volume of 3.5 cm H2O/L.	Water	127-130	prolyl 4-hydroxylase subunit beta	Homo sapiens	85-88
8899891-8	1996	Central blockade of AT1 receptor with KR 31080 and cholinergic receptor with atropine attenuated water intake more than 50% which was significantly greater than inhibition produced by losartan and CGP 42112A.	Water	97-102	angiotensin II receptor, type 1a	Rattus norvegicus	20-23
8904639-12	1996	We submit the hypothesis that the alpha 2a- and alpha 2b-adrenoceptor subtypes mediated the clonidine-induced osmolar and free water clearance.	Water	127-132	adrenoceptor alpha 2A	Rattus norvegicus	34-69
8874494-7	1996	A model for water-coordinated transport, providing a qualitative view of the porin transport mechanism, is also described.	Water	12-17	voltage dependent anion channel 1	Homo sapiens	77-82
8888143-4	1996	Functional group maps of the RNase A structure were calculated using the Multiple Copy Simultaneous Search (MCSS) method and compared with experimentally determined formate and water positions.	Water	177-182	ribonuclease A family member 1, pancreatic	Homo sapiens	29-36
18966629-1	1996	Considerable disparity exists in the published thermodynamic data for selected species in the Ca(2+) /CO(2)/H(2)O system near 25 degrees C and 1 atm pressure.	Water	108-113	cullin associated and neddylation dissociated 1	Homo sapiens	137-144
8987547-1	1996	Soluble egg shell membrane protein (SEP) was prepared from egg shell membrane by the combined treatment of performic acid oxidation (4 or 25 degrees C for 24 h) and pepsin digestion (25 degrees C for 24-72 h) before dialyzing against water and lyophilizing.	Water	234-239	membrane metalloendopeptidase like 1	Homo sapiens	36-39
8799714-2	1996	A different rate of interchange between the solid matrix and the water solution was found for FB1 and FB2 and some differences were found in the fate of both fumonisins between the two steeping systems studied.	Water	65-70	Protein DEHYDRATION-INDUCED 19 homolog 5	Zea mays	102-105
8690065-1	1996	Two-dimensional (2D) crystals of rabbit C-reactive protein (CRP) have been obtained by protein binding on lipid monolayers at the air/water interface.	Water	134-139	C-reactive protein	Oryctolagus cuniculus	40-58
8690065-1	1996	Two-dimensional (2D) crystals of rabbit C-reactive protein (CRP) have been obtained by protein binding on lipid monolayers at the air/water interface.	Water	134-139	C-reactive protein	Oryctolagus cuniculus	60-63
8652186-12	1996	The well-known functions of these epithelia are to elaborate cerebrospinal fluid and aqueous humor respectively by processes of active ion transport and water fluxes, probably through the aquaporin 1 (channel-forming integral membrane protein [CHIP] 28).	Water	153-158	aquaporin 1	Rattus norvegicus	188-199
8909788-2	1996	To address these questions, we developed and applied a method for measuring lipogenesis using the uptake of deuterium from heavy water into triglyceride fatty acids (TGFA) in humans.	Water	129-134	transforming growth factor alpha	Homo sapiens	166-170
8675028-4	1996	Western blotting analysis of cell extracts revealed that Pho86p, tagged with c-Myc, was fractionated into a water-insoluble fraction.	Water	108-113	Pho86p	Saccharomyces cerevisiae S288C	57-63
8647834-9	1996	Moreover, inner medullary Osp94 expression was increased during water restriction when osmolality is known to increase.	Water	64-69	heat shock protein 4 like	Mus musculus	26-31
8735618-15	1996	We therefore suggest that the upregulation of the medullary ETB in cirrhotic rats is involved in the regulation of water excretion in rats with CCl4-induced liver cirrhosis.	Water	115-120	endothelin receptor type B	Rattus norvegicus	60-63
8933206-10	1996	Stimulation with a sonicated B. burgdorferi preparation in the presence of the water-soluble compound Prednisolone-21-hemisuccinate considerably reduced expression of ICAM-1, and marginally also of E-selectin, whereas the level of P-selectin and VCAM-1 remained unaltered.	Water	79-84	intercellular adhesion molecule 1	Mus musculus	167-173
8685265-4	1996	However, although anaerobic alcohol dehydrogenase gene induction occurred in seedlings exposed to water-agar medium and in roots, related luminescence responses were absent.	Water	98-103	alcohol dehydrogenase 1	Arabidopsis thaliana	28-49
11539267-6	1996	The ligation rates observed with the different divalent metal ion catalysts (Mn2+ &gt; Mg2+ &gt; Ca2+ &gt; Sr2+ = Ba2+) vary inversely with the pKa values of their bound water molecules.	Water	170-175	mucin 7, secreted	Homo sapiens	87-90
8780259-0	1996	Direct demonstration of aquaporin-2 water channel recycling in stably transfected LLC-PK1 epithelial cells.	Water	36-41	aquaporin 2	Sus scrofa	24-35
8962641-5	1996	CONCLUSION: By itself in water the carboxyl terminal peptide of hCG lacks defined secondary structure elements and is thus likely a random coil.	Water	25-30	chorionic gonadotropin subunit beta 5	Homo sapiens	64-67
8737213-5	1996	Analysis of the mean (SD) differences in heart rate between fasting and the post-prandial state for the different meals revealed a significant increase between water and the other meals, fat (+4(6) beats.min-1 P &lt; 0.002), balanced (+9(17) beats.min-1 P &lt; 0.004), and carbohydrate (+10(12) beats.min-1 P &lt; 0.0002).	Water	160-165	FAT atypical cadherin 1	Homo sapiens	187-190
8785398-8	1996	In water-deprived, sodium-loaded, and potassium-loaded rats, the inner medullary sorbitol content increased significantly in accordance with the rise in the enzymatic activity and the level of aldose reductase mRNA.	Water	3-8	aldo-keto reductase family 1 member B1	Rattus norvegicus	193-209
8745402-3	1996	Catalytic rate measurements on single and double mutants indicate that pK1 is mainly due to the deprotonation of Lys 120 and Lys 134, with only a minor contribution from other surface basic residues, whereas pK2 is due to titration of the invariant Arg 141, likely coupled to deprotonation of the copper-bound water molecule.	Water	310-315	prokineticin 1 L homeolog	Xenopus laevis	71-74
8661821-4	1996	In this study we evaluated the effects of CCK and PYY on intestinal absorption of water and electrolytes.	Water	82-87	peptide YY	Canis lupus familiaris	50-53
8769778-6	1996	The functional role of these water channels in transport was examined in rat lungs perfused in situ with tritiated water by testing known inhibitors of aquaporin-1-mediated transmembrane water transport.	Water	29-34	aquaporin 1	Rattus norvegicus	152-163
8769778-6	1996	The functional role of these water channels in transport was examined in rat lungs perfused in situ with tritiated water by testing known inhibitors of aquaporin-1-mediated transmembrane water transport.	Water	115-120	aquaporin 1	Rattus norvegicus	152-163
8769778-6	1996	The functional role of these water channels in transport was examined in rat lungs perfused in situ with tritiated water by testing known inhibitors of aquaporin-1-mediated transmembrane water transport.	Water	115-120	aquaporin 1	Rattus norvegicus	152-163
8769778-8	1996	Just like certain epithelia, endothelia might express physiologically relevant amounts of aquaporin-1 on their cell surface to permit direct, mercurial-sensitive, transcellular transport of water.	Water	190-195	aquaporin 1	Rattus norvegicus	90-101
8925815-3	1996	With the continuation of the cold water immersions (three times a week for a duration of 6 weeks) a small, but significant, increase in the proportions of monocytes, lymphocytes with expressed IL2 receptors (CD25) and in plasma tumour necrosis factor alpha content was induced.	Water	34-39	interleukin 2 receptor subunit alpha	Homo sapiens	208-212
8822570-4	1996	Regional cerebral blood flow (rCBF) during performance of oculomotor tasks was measured with [15O]-H2O positron emission tomography (PET).	Water	99-102	CCAAT/enhancer binding protein zeta	Rattus norvegicus	30-34
8845371-1	1995	The binding site of the dopamine D2 receptor, like that of other homologous G-protein-coupled receptors, is contained within a water-accessible crevice formed among its seven membrane-spanning segments.	Water	127-132	dopamine receptor D2	Homo sapiens	24-44
8562030-8	1995	In contrast, the mean vv(nuc) of sections mounted from water was 459 microns3, approximately 30% larger (2p &lt; or = 0.02).	Water	55-60	nucleobindin 1	Homo sapiens	25-28
8789194-8	1995	Our analysis reveals that there are as many as 16 conserved water molecules at the FAD binding site of glutathione reductase between the crystal structures obtained from human and E. coli.	Water	60-65	glutathione-disulfide reductase	Homo sapiens	103-124
8576328-10	1995	Strains belonging to the same ribotypes (ribotypes VIII to X) were isolated from both patients and surface water in Bangladesh, indicating possible transmission through surface water.	Water	107-112	cytochrome c oxidase subunit 8A	Homo sapiens	51-55
8576328-10	1995	Strains belonging to the same ribotypes (ribotypes VIII to X) were isolated from both patients and surface water in Bangladesh, indicating possible transmission through surface water.	Water	177-182	cytochrome c oxidase subunit 8A	Homo sapiens	51-55
10462487-5	1999	These key features have been investigated on the water-soluble ectodomain of the hemagglutinin-neuraminidase from Sendai virus (cHN).	Water	49-54	neuraminidase 1	Homo sapiens	95-108
10434022-5	1999	This study examines the influence of the presence of traces of iron or copper ions during gamma-irradiation of plasmid DNA in water, on the possible formation of mutational hot spots in the lacI gene.	Water	126-131	tissue factor pathway inhibitor	Homo sapiens	190-194
10401872-4	1999	Surface water source was also associated with neural tube defects (POR = 1.5; 95% CI = 0.9-2.5).	Water	8-13	ADP ribosylation factor interacting protein 2	Homo sapiens	67-74
10398984-6	1999	The CSI water-selective image provided a detailed description of thymic location, shape, and dimensions.	Water	8-13	corticosteroid side chain isomerase activity	Mus musculus	4-7
10411689-3	1999	The osmotic water permeability of LLC-PK1 cells expressing AQP2 mutants was determined by stopped-flow light-scattering microphotometry.	Water	12-17	aquaporin 2	Sus scrofa	59-63
10387039-1	1999	The binding-site of the dopamine D2 receptor, like that of other homologous G protein-coupled receptors, is contained within a water-accessible crevice formed among its seven membrane-spanning segments.	Water	127-132	dopamine receptor D2	Homo sapiens	24-44
10356328-0	1999	Large-scale networks of hydration water molecules around bovine beta-trypsin revealed by cryogenic X-ray crystal structure analysis.	Water	34-39	serine protease 1	Bos taurus	64-76
10224234-10	1999	Inhibition of the downstream consequences of ST-GCC interaction reflects proximal disruption of cGMP production because 8-bromo-cGMP stimulated chloride current and water secretion in 2ClAdo-treated cells.	Water	165-170	guanylate cyclase 2C	Homo sapiens	48-51
10232700-1	1999	Several aquaporin-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the collecting duct; AQP6 in the papilla; and AQP7 in the proximal tubule.	Water	23-28	aquaporin 1	Mus musculus	63-67
10090754-3	1999	Fhit is here shown to catalyze the hydrolysis in H218O with production of adenosine 5"-[18O]phosphate and ADP, proving that the substitution of water is at Palpha and not at Pbeta.	Water	144-149	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
10090758-8	1999	1,2H ENDOR of NOHA bound to holo-nNOS in H2O and D2O discloses the presence of a single resolved exchangeable proton (H1) 4.8 A from Fe and very near the heme normal.	Water	41-44	nitric oxide synthase 1	Homo sapiens	33-37
10080163-1	1999	Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models.	Water	63-68	peptide YY	Canis lupus familiaris	119-129
10021457-0	1999	Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice.	Water	8-13	aquaporin 1	Mus musculus	90-101
10021457-2	1999	Freeze-fracture electron microscopy (FFEM) of rat TDLH has shown an exceptionally high density of intramembrane particles (IMPs), which were proposed to consist of tetramers of aquaporin-1 (AQP1) water channels.	Water	196-201	aquaporin 1	Rattus norvegicus	190-194
10077036-6	1999	The 1/T1 and 1/T2 relaxivities decreased as the temperature decreased for each generation of dendrimer studied, implying that slow water exchange of bound water molecules with the bulk solvent limits the relaxivity.	Water	131-136	interleukin 1 receptor like 1	Homo sapiens	6-14
10077036-6	1999	The 1/T1 and 1/T2 relaxivities decreased as the temperature decreased for each generation of dendrimer studied, implying that slow water exchange of bound water molecules with the bulk solvent limits the relaxivity.	Water	155-160	interleukin 1 receptor like 1	Homo sapiens	6-14
9888815-0	1999	Dynamics of protein-bound water in the heme domain of P450BM3 studied by high-pressure spectroscopy: comparison with P450cam and P450 2B4.	Water	26-31	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	54-58
10397798-5	1999	In both H2O and a 1:1 mixture of H2O and trifluoroethanol this polypeptide segment shows high helix propensity, which is a key issue in discussions on potential roles of this molecular region in conformational transitions of PrP.	Water	8-11	prion protein	Mus musculus	225-228
10397798-5	1999	In both H2O and a 1:1 mixture of H2O and trifluoroethanol this polypeptide segment shows high helix propensity, which is a key issue in discussions on potential roles of this molecular region in conformational transitions of PrP.	Water	33-36	prion protein	Mus musculus	225-228
10490684-7	1999	After 1-day immersion in water, tensile testing revealed that the bond strength was influenced by the application of cytochrome c and HEMA.	Water	25-30	LOC104968582	Bos taurus	117-129
21080262-3	1999	Its application to the binary complex formed by the inserted-domain (I-domain) of the leukocyte function-associated antigen-1 (LFA-1) with a ligand reveals the presence of H2O molecules at the binding interface.	Water	172-175	integrin subunit alpha L	Homo sapiens	86-125
21080262-3	1999	Its application to the binary complex formed by the inserted-domain (I-domain) of the leukocyte function-associated antigen-1 (LFA-1) with a ligand reveals the presence of H2O molecules at the binding interface.	Water	172-175	integrin subunit alpha L	Homo sapiens	127-132
9916798-5	1999	After 24 hours of water deprivation, Clcnk1-/- mice were severely dehydrated and lethargic, with a decrease of approximately 27% in body weight.	Water	18-23	chloride channel, voltage-sensitive Ka	Mus musculus	37-43
9838003-12	1998	We also find that many of the water-mediated hydrogen bonds between the a1 and alpha2 homeodomains and the DNA are highly conserved, indicating an important role for water in stabilization of the a1/alpha2-DNA complex.	Water	30-35	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	79-85
9838003-12	1998	We also find that many of the water-mediated hydrogen bonds between the a1 and alpha2 homeodomains and the DNA are highly conserved, indicating an important role for water in stabilization of the a1/alpha2-DNA complex.	Water	30-35	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	199-205
9838003-12	1998	We also find that many of the water-mediated hydrogen bonds between the a1 and alpha2 homeodomains and the DNA are highly conserved, indicating an important role for water in stabilization of the a1/alpha2-DNA complex.	Water	166-171	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	79-85
9838003-12	1998	We also find that many of the water-mediated hydrogen bonds between the a1 and alpha2 homeodomains and the DNA are highly conserved, indicating an important role for water in stabilization of the a1/alpha2-DNA complex.	Water	166-171	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	199-205
9951557-9	1998	These results suggest that both AT1 and V1 receptors within the SON may be involved in water and sodium intake induced by the activation of ANG II receptors within the MSA.	Water	87-92	angiotensin II receptor, type 1a	Rattus norvegicus	32-42
9822113-5	1998	AQP1 null mice are mildly growth-retarded, manifest a severe urinary concentrating defect, and have reduced water permeability between airspace and capillary compartments.	Water	108-113	aquaporin 1	Mus musculus	0-4
9772029-2	1998	Regional cerebral blood flow (rCBF) determined by 15O-water was used to flow compensate two nicotine model parameters, k1 and k2, obtained in a two-compartment kinetic model.	Water	54-59	CCAAT/enhancer binding protein zeta	Rattus norvegicus	30-34
9731010-8	1998	Transdiaphragmatic pressure (Pdi) in five patients was 66 +/- 13 cm H2O.	Water	68-71	prolyl 4-hydroxylase subunit beta	Homo sapiens	29-32
9774237-5	1998	In the current study, we analyzed the conformation of [Leu11,D-Trp12, Lys26,Asp30]PTHrP(7-34)NH2 (hybrid-lactam) in a 1:1 mixture of H2O/TFE-d3 at pH approximately equal to 4 by circular dichroism, nuclear magnetic resonance and distance geometry calculations.	Water	133-136	parathyroid hormone like hormone	Homo sapiens	82-87
9694833-6	1998	Both the Ad12 and Ad5 peptides dissolved in trifluoroethanol/water mixtures were found to adopt regular secondary structural conformations seen as a series of beta-turns.	Water	61-66	Alzheimer disease, familial, type 5	Homo sapiens	18-21
9729254-4	1998	Pretreatment of the SFO with an AT1 receptor antagonist, losartan (1 microgram/200 nl), reduced water intake but not 0.3 M NaCl intake induced by subcutaneous FURO+CAP.	Water	96-101	angiotensin II receptor type 1	Homo sapiens	32-35
9689137-1	1998	To investigate the role of aquaporin-1 (AQP1) water channels in proximal tubule function, in vitro proximal tubule microperfusion and in vivo micropuncture measurements were done on AQP1 knockout mice.	Water	46-51	aquaporin 1	Mus musculus	40-44
9689137-4	1998	Transepithelial osmotic water permeability (Pf) in isolated microperfused S2 segments of proximal tubule from AQP1 knockout [-/-] mice was 0.033 +/- 0.005 cm/s (SE, n = 6 mice, 37 degreesC), much lower than that of 0.15 +/- 0.03 cm/s (n = 8) in tubules from wild-type [+/+] mice (P &lt; 0.01).	Water	24-29	aquaporin 1	Mus musculus	110-114
9689137-9	1998	These data indicate that AQP1 deletion in mice results in decreased transepithelial proximal tubule water permeability and defective fluid absorption.	Water	100-105	aquaporin 1	Mus musculus	25-29
9689137-10	1998	Thus, the high water permeability in proximal tubule of wild-type mice is primarily transcellular, mediated by AQP1 water channels, and required for efficient near-isosmolar fluid absorption.	Water	15-20	aquaporin 1	Mus musculus	111-115
9689137-10	1998	Thus, the high water permeability in proximal tubule of wild-type mice is primarily transcellular, mediated by AQP1 water channels, and required for efficient near-isosmolar fluid absorption.	Water	116-121	aquaporin 1	Mus musculus	111-115
9651190-0	1998	Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels.	Water	82-87	podoplanin	Homo sapiens	60-67
9651190-0	1998	Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels.	Water	129-134	podoplanin	Homo sapiens	60-67
9651190-2	1998	The purpose of this study was to test the hypothesis that T1alpha functions as a water channel or a regulator of aquaporin-type water channels that are coexpressed with T1alpha.	Water	81-86	podoplanin	Homo sapiens	58-65
9651190-2	1998	The purpose of this study was to test the hypothesis that T1alpha functions as a water channel or a regulator of aquaporin-type water channels that are coexpressed with T1alpha.	Water	128-133	podoplanin	Homo sapiens	58-65
9651190-11	1998	Quantitative densitometry indicated that the single-channel water permeability of T1alpha is under 2 x 10(-16) cm3/s, suggesting that T1alpha is not involved in the high transalveolar water permeability in intact lung.	Water	60-65	podoplanin	Homo sapiens	82-89
9752691-7	1998	However, salt and water craving in dialysis patients may be influenced partially by an active ALDH2 gene.	Water	18-23	aldehyde dehydrogenase 2 family member	Homo sapiens	94-99
9649343-5	1998	These water molecules are identified with some or all of six ordered water molecules partly buried in surface pockets in the crystal structure of RNase A.	Water	6-11	ribonuclease A family member 1, pancreatic	Homo sapiens	146-153
9649343-5	1998	These water molecules are identified with some or all of six ordered water molecules partly buried in surface pockets in the crystal structure of RNase A.	Water	69-74	ribonuclease A family member 1, pancreatic	Homo sapiens	146-153
8558603-8	1995	Single molecule water permeabilities (pfs) of 1.4 x 10(-14) cm3/sec for CHIP and of 1.5 x 10(-16) cm3/sec for MIP were estimated from the ratio of the whole-oocyte water permeability (Pf) to the density of particles.	Water	16-21	major intrinsic protein of lens fiber L homeolog	Xenopus laevis	110-113
8819977-4	1995	Two water molecules formed hydrogen bond bridges between beta2 and beta3, in agreement with X-ray crystallographic data and a recent reassessment of the solution structure using time-averaged NMR restraints during MD refinement.	Water	4-9	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	57-72
19209424-1	2009	This work deals with the self-assembly in water of ABC miktoarm star terpolymers consisting of hydrophobic poly(-caprolactone), hydrophilic poly(ethylene oxide) (PEO), and pH-sensitive poly(2-vinylpyridine) (P2VP).	Water	42-47	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	51-54
8777059-2	1995	This tetrazolium, commonly referred to as MTS [3-(4,5-dimethylthiazol-2-yl)- 5-(3-carboxymethonyphenol)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt], has the unusual property that it can be reduced to a water-soluble formazan.	Water	204-209	MLRL	Homo sapiens	42-45
9585525-10	1998	In addition, a well-ordered water molecule is found in the PNP active site when purine base or nucleoside is also present.	Water	28-33	purine nucleoside phosphorylase	Bos taurus	59-62
9692673-2	1998	Neuronal AT1 receptors mediate the stimulatory actions of Ang II on blood pressure, water and salt intake, and secretion of vasopressin.	Water	84-89	angiotensin II receptor type 1	Homo sapiens	9-12
18849157-2	2009	The channel with an appropriate diameter of about 3A ( approximately 3A) existing in SAMs on Au is deduced, which is found large enough for ions and water molecules to permeate; (2) through summarizing the literature reports for various experiments (e.g. scan microscopy techniques and electrochemical methods, etc.	Water	149-154	methionine adenosyltransferase 1A	Homo sapiens	85-89
9575903-5	1998	Staining with an antibody against the aquaporin-1 water channel showed the distribution of cells from the ascending and descending limbs to be approximately equal in the isolated population.	Water	50-55	aquaporin 1	Rattus norvegicus	38-49
15348892-14	1998	HAp formed by hydrolysis in water was needle-like to globular while that formed in the sodium phosphate solution exhibited a florette-like morphology.	Water	28-33	reticulon 3	Homo sapiens	0-3
8574327-1	1995	We investigated the expression and changes in the intracellular localization of a 72-kDa heat shock protein (HSP72) in rat gastric pyloric and fundic mucosa before and after water-immersion stress.	Water	174-179	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	109-114
8574327-4	1995	HSP72 in both the soluble and insoluble fractions of the pyloric and the fundic mucosal areas was significantly increased after water-immersion stress, peaking 6h after the initiation of the stress.	Water	128-133	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	0-5
8801345-2	1995	The power-consumption-controlled extruder (pcc-extruder) is an appropriate tool to adjust the required water content to yield round pellets.	Water	103-108	crystallin gamma D	Homo sapiens	43-46
18849157-3	2009	), the existence of the ion and water channels ( approximately 3A) in close-packed C(n)SH-SAMs is verified; (3) furthermore, the effect of the ions and water molecules permeation on the studies of the SAMs" electron tunneling process is discussed.	Water	32-37	methionine adenosyltransferase 1A	Homo sapiens	90-94
9606179-8	1998	This is true for both the water- and lipid-soluble fractions of SP-A.	Water	26-31	surfactant protein A1	Homo sapiens	64-68
18849157-3	2009	), the existence of the ion and water channels ( approximately 3A) in close-packed C(n)SH-SAMs is verified; (3) furthermore, the effect of the ions and water molecules permeation on the studies of the SAMs" electron tunneling process is discussed.	Water	152-157	methionine adenosyltransferase 1A	Homo sapiens	90-94
18849157-3	2009	), the existence of the ion and water channels ( approximately 3A) in close-packed C(n)SH-SAMs is verified; (3) furthermore, the effect of the ions and water molecules permeation on the studies of the SAMs" electron tunneling process is discussed.	Water	152-157	methionine adenosyltransferase 1A	Homo sapiens	201-206
9724927-1	1998	Nonionic and anionic water-soluble amphiphiles were shown to increase strongly the binding of fluorescein isothiocyanate-conjugated annexin V (FITC-annexin V) in human erythrocytes pretreated with the aminophospholipid translocase (APLT) inhibitor n-ethylmaleimide (NEM).	Water	21-26	ATPase phospholipid transporting 8A1	Homo sapiens	201-230
9724927-1	1998	Nonionic and anionic water-soluble amphiphiles were shown to increase strongly the binding of fluorescein isothiocyanate-conjugated annexin V (FITC-annexin V) in human erythrocytes pretreated with the aminophospholipid translocase (APLT) inhibitor n-ethylmaleimide (NEM).	Water	21-26	ATPase phospholipid transporting 8A1	Homo sapiens	232-236
18849157-4	2009	This simple ideal model of the close-packed C(n)SH-SAMs established by us may clarify the controversies about the permeation mechanism of ions and water molecules in C(n)SH-SAMs.	Water	147-152	methionine adenosyltransferase 1A	Homo sapiens	51-55
7556498-1	1995	We have expressed frog (Rana pipiens) lens major intrinsic protein (MIP) in Xenopus oocytes and observed its effect on ion conductance, water permeability and neutral solute transport.	Water	136-141	major intrinsic protein of lens fiber L homeolog	Xenopus laevis	68-71
18849157-4	2009	This simple ideal model of the close-packed C(n)SH-SAMs established by us may clarify the controversies about the permeation mechanism of ions and water molecules in C(n)SH-SAMs.	Water	147-152	methionine adenosyltransferase 1A	Homo sapiens	173-177
7556498-5	1995	MIP increased oocyte water permeability by a factor of 1.9 +/- 0.2, whereas the permeability to sucrose, 2-deoxyglucose, inositol, sorbitol, reduced glutathione or urea was unchanged.	Water	21-26	major intrinsic protein of lens fiber L homeolog	Xenopus laevis	0-3
9514739-6	1998	However, a number of water molecules found in the free SEB may be displaced in the complex or contribute further to its stability.	Water	21-26	SET binding protein 1	Homo sapiens	55-58
19439982-0	2009	Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Actinidia arguta.	Water	97-102	interphotoreceptor matrix proteoglycan 2	Mus musculus	88-93
9518582-3	1998	Monolayers of pure SP-B or SP-C isolated from butanol lipid extracts spread at the air-water interface showed larger molecular areas than those determined in films of SP-B or SP-C isolated from chloroform surfactant extracts.	Water	87-92	surfactant protein B	Homo sapiens	19-23
9518582-4	1998	Aqueous dispersions of dipalmitoylphosphatidylcholine (DPPC) supplemented with 2.5 and 5.0 wt% of SP-B or SP-C obtained from butanol extracts adsorbed faster to the air-water interface than their counterparts reconstituted with proteins isolated from chloroform extracts.	Water	169-174	surfactant protein B	Homo sapiens	98-102
9578142-2	1998	Aquaporin 1 (AQP1, also known as CHIP, channel forming integral membrane protein of 28 kDa) is the first identified protein to function as a water channel and has been recently shown to be present in the rat retina.	Water	141-146	aquaporin 1	Rattus norvegicus	0-11
7544358-6	1995	To determine if this activity was associated with the expression of the prototypical water channel (aquaporin, AQP) AQP1, we used three separate experimental approaches; Northern analysis and reverse transcription-polymerase chain reaction (RT-PCR) analysis of isolated mRNA, and Western analysis of cell membranes.	Water	85-90	aquaporin 1	Rattus norvegicus	116-120
7550325-2	1995	Biotinidase-deficient children cannot recycle endogenous biotin, an essential water-soluble B vitamin.	Water	78-83	biotinidase	Homo sapiens	0-11
9578142-2	1998	Aquaporin 1 (AQP1, also known as CHIP, channel forming integral membrane protein of 28 kDa) is the first identified protein to function as a water channel and has been recently shown to be present in the rat retina.	Water	141-146	aquaporin 1	Rattus norvegicus	13-17
18830379-4	2009	The expression of MIP-2 correlates with NF-kappaB activation and brain water content.	Water	71-76	C-X-C motif chemokine ligand 2	Rattus norvegicus	18-23
9510962-3	1998	Catalase activates the decomposition of H2O2 into water and oxygen, thus removing an initiator of free radical chain reactions leading to lipid peroxidation.	Water	50-55	catalase	Bos taurus	0-8
8539241-2	1995	These hydration sites include a subset of the observed water molecules plus some sites that are occupied by neighboring protein atoms in the FK506-FKBP12 crystal structure.	Water	55-60	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	147-153
8539241-3	1995	Two hydration prediction algorithms, AUTO-SOL and AQUARIUS2, showed significant increases in apparent efficacy using these consensus water sites, suggesting that our proposed set of consensus hydration sites is truly a better representation of the hydration properties of FKBP12 in solution.	Water	133-138	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	272-278
19192361-4	2009	The dry body of HAp/PAM nanocomposite cracked after the immersion test in water, but the cross-linked sample using glutaraldehyde did not crack.	Water	74-79	reticulon 3	Homo sapiens	16-19
7559079-0	1995	Elevated serum growth hormone accelerates gastric tumorigenesis in F344 rats after treatment with N-methyl-N-nitrosourea in their drinking water.	Water	139-144	gonadotropin releasing hormone receptor	Rattus norvegicus	15-29
9521541-1	1998	Event-related potentials (ERP) and regional cerebral blood flow (rCBF) activation using 15O-labeled water associated with retrieval and retention of episodic memory were studied during a visual paired-association task with delayed response in eight healthy subjects.	Water	100-105	CCAAT/enhancer binding protein zeta	Rattus norvegicus	65-69
19192361-5	2009	The macrocomposite of HAp/GEL nanocomposite and HAp/PAM nanocomposite showed good toughness, but cracked after the immersion test in water.	Water	133-138	reticulon 3	Homo sapiens	22-25
19192361-5	2009	The macrocomposite of HAp/GEL nanocomposite and HAp/PAM nanocomposite showed good toughness, but cracked after the immersion test in water.	Water	133-138	reticulon 3	Homo sapiens	48-51
9468475-1	1998	Water channel aquaporin-1 (AQP1) is strongly expressed in kidney in proximal tubule and descending limb of Henle epithelia and in vasa recta endothelia.	Water	0-5	aquaporin 1	Mus musculus	14-25
9468475-1	1998	Water channel aquaporin-1 (AQP1) is strongly expressed in kidney in proximal tubule and descending limb of Henle epithelia and in vasa recta endothelia.	Water	0-5	aquaporin 1	Mus musculus	27-31
7541952-0	1995	Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney.	Water	12-17	aquaporin 1	Rattus norvegicus	0-11
7541952-11	1995	AQP-1 is localized in both apical and basolateral plasma membranes, which is logical for transendothelial water transport.	Water	106-111	aquaporin 1	Rattus norvegicus	0-5
20224196-15	2009	Luminal nucleotides are prone to activate luminal P2 receptors which in turn are well described to inhibit AVP-augmented aquaporin-2-dependent water absorption or ENaC-mediated Na(+) transport (8).	Water	143-148	arginine vasopressin	Mus musculus	107-110
9454590-1	1998	The binding site of the dopamine D2 receptor, like that of other homologous G protein-coupled receptors, is contained within a water-accessible crevice formed among its seven membrane-spanning segments.	Water	127-132	dopamine receptor D2	Homo sapiens	24-44
9435270-0	1998	Reconstitution of a regulated transepithelial water pathway in cells transfected with AQP2 and an AQP1/AQP2 hybrid containing the AQP2-C terminus.	Water	46-51	aquaporin 2	Sus scrofa	86-90
19430192-2	2009	The melting point of the hydrated solid of the water/C(16)SE/C(12)EO(3) system is around 34 degrees C. When C(16)SE is substituted with sodium dodecyl sulfate (SDS), the melting point of the hydrated solid decreases below 5 degrees C at alpha (weight fraction of SDS in C(16)SE+SDS mixture) being greater than 0.3 and the zero shear viscosity (eta(0)) increases from the original nonionic system.	Water	47-52	endothelin receptor type A	Homo sapiens	344-347
9435270-0	1998	Reconstitution of a regulated transepithelial water pathway in cells transfected with AQP2 and an AQP1/AQP2 hybrid containing the AQP2-C terminus.	Water	46-51	aquaporin-1	Sus scrofa	98-102
9435270-0	1998	Reconstitution of a regulated transepithelial water pathway in cells transfected with AQP2 and an AQP1/AQP2 hybrid containing the AQP2-C terminus.	Water	46-51	aquaporin 2	Sus scrofa	103-107
9435270-0	1998	Reconstitution of a regulated transepithelial water pathway in cells transfected with AQP2 and an AQP1/AQP2 hybrid containing the AQP2-C terminus.	Water	46-51	aquaporin 2	Sus scrofa	103-107
9417019-2	1998	Comparison of the measured concentrations of OH and HO2 with calculations based on their production from water vapor, ozone, and methane demonstrate that these sources are insufficient to explain the observed radical concentrations in the upper troposphere.	Water	106-111	heme oxygenase 2	Homo sapiens	53-56
9711468-3	1998	In the present study, we have shown that Uriage spring water induced in vitro the apoptosis of IL-5-primed eosinophils.	Water	55-60	interleukin 5	Homo sapiens	95-99
18470493-2	1998	BothD: -xylose andD: -mannose reduce the cell water content andD: -galactose does occasionally the same but onlyD: -xylose reduces significantly the intracellular sodium concentration, presumably by forming steric hindrances at the outlets of the sodium pumps at the outer surface of the cell membrane.	Water	46-51	secretion associated Ras related GTPase 1B	Homo sapiens	15-19
18470493-2	1998	BothD: -xylose andD: -mannose reduce the cell water content andD: -galactose does occasionally the same but onlyD: -xylose reduces significantly the intracellular sodium concentration, presumably by forming steric hindrances at the outlets of the sodium pumps at the outer surface of the cell membrane.	Water	46-51	secretion associated Ras related GTPase 1B	Homo sapiens	60-64
28466525-2	1998	Tap water (or normal saline) was boiled, and agar (or Gelrite) powder was dissolved in it.	Water	4-9	tracheal antimicrobial peptide	Bos taurus	0-3
9857378-4	1998	Circulating Ang II concentrations (10(-12) to 10(-10) M), increased NaCl, water and NaHCO3 reabsorption via NHE3 in the proximal tubule.	Water	74-79	angiogenin	Homo sapiens	12-15
9857378-6	1998	Luminal ANG II originating from kidney has a physiological autocrine function on NaCl, water and probably NaHCO3 reabsorption, since inhibiting Ang II synthesis, by conversion enzyme inhibition, or effect, by AT1 receptor antagonists, induces a reduction of proximal tubule reabsorption.	Water	87-92	angiogenin	Homo sapiens	8-11
9484466-12	1998	Immunoblot analyses have facilitated a demonstration that HvOxOLP, like oxalate oxidase, is a water-soluble 100 kDa oligomeric protein.	Water	94-99	LOC548260	Hordeum vulgare	72-87
9391071-1	1997	Aldehyde dehydrogenase class 3 (ALDH3) constitutes 20-40% of the total water-soluble proteins in the mammalian cornea.	Water	71-76	aldehyde dehydrogenase 3 family member A1	Homo sapiens	0-30
9391071-1	1997	Aldehyde dehydrogenase class 3 (ALDH3) constitutes 20-40% of the total water-soluble proteins in the mammalian cornea.	Water	71-76	aldehyde dehydrogenase 3 family member A1	Homo sapiens	32-37
9384574-8	1997	When the Lpp-LolA complex was incubated with a water-soluble LolB derivative, Lpp was transferred from LolA to LolB.	Water	47-52	lipoprotein	Escherichia coli	9-12
9384574-8	1997	When the Lpp-LolA complex was incubated with a water-soluble LolB derivative, Lpp was transferred from LolA to LolB.	Water	47-52	lipoprotein	Escherichia coli	78-81
9402049-1	1997	We have characterized the action of the novel, water-soluble, tachykinin NK2 receptor antagonist MEN 11420 ([Asn(2-AcNH-beta-D-Glc)-Asp-Trp-Phe-Dap-Leu] c(2 beta-5 beta)) on the circular muscle of the guinea-pig and human colon in vitro and on the guinea-pig colon in vivo.	Water	47-52	death associated protein	Homo sapiens	144-147
9396229-7	1997	The proliferation response of lymph node cells from TGF-beta 1 injected mice with IRBP-induced EAU was suppressed compared with phosphate buffered saline (PBS)-injected mice.	Water	95-98	transforming growth factor, beta 1	Mus musculus	52-62
9353594-7	1997	PrP-/- mice showed impaired performance in the water-finding test, indicating a disturbance in latent learning, at 23 weeks of age.	Water	47-52	prion protein	Mus musculus	0-3
9322917-0	1997	Water deprivation increases the expression of pituitary adenylate cyclase-activating polypeptide gene in the rat subfornical organ.	Water	0-5	adenylate cyclase activating polypeptide 1	Rattus norvegicus	46-96
9322917-1	1997	The effect of water deprivation on the expression of pituitary adenylate cyclase-activating polypeptide (PACAP) was examined in the rat subfornical organ (SFO), using a combination of immunohistochemistry and in situ hybridization histochemistry.	Water	14-19	adenylate cyclase activating polypeptide 1	Rattus norvegicus	53-103
9322917-1	1997	The effect of water deprivation on the expression of pituitary adenylate cyclase-activating polypeptide (PACAP) was examined in the rat subfornical organ (SFO), using a combination of immunohistochemistry and in situ hybridization histochemistry.	Water	14-19	adenylate cyclase activating polypeptide 1	Rattus norvegicus	105-110
9322917-3	1997	Water deprivation for 24 h and 48 h caused a significant increase in PACAP gene transcripts in the SFO, compared with euhydrated animals.	Water	0-5	adenylate cyclase activating polypeptide 1	Rattus norvegicus	69-74
9322917-4	1997	Additionally, water deprivation for 48 h caused an increase in PACAP-IR.	Water	14-19	adenylate cyclase activating polypeptide 1	Rattus norvegicus	63-68
9322917-7	1997	These results suggest that PACAP in the SFO may play a role in the humoral and neural changes associated with the regulation of body fluid balance after water deprivation.	Water	153-158	adenylate cyclase activating polypeptide 1	Rattus norvegicus	27-32
9387945-1	1997	The long-acting beta2-agonist salmeterol inhibits in vitro the release of inflammatory mediators up to 20 h. These mediators are involved in ultrasonically nebulized distilled water (UNDW)-induced bronchoconstriction.	Water	176-181	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	16-21
9344515-0	1997	Probing the Sol-Gel Conversion in the Tetraethoxysilane/Alcohol/Water System with the Aid of Diffusion-Controlled Fluorescence Quenching The sol-gel conversion in the tetraethoxysilane/alcohol/water system can be probed by means of the diffusion-controlled fluorescence quenching of Py* by Cu2+ ions.	Water	64-69	activation induced cytidine deaminase	Homo sapiens	86-89
9344515-0	1997	Probing the Sol-Gel Conversion in the Tetraethoxysilane/Alcohol/Water System with the Aid of Diffusion-Controlled Fluorescence Quenching The sol-gel conversion in the tetraethoxysilane/alcohol/water system can be probed by means of the diffusion-controlled fluorescence quenching of Py* by Cu2+ ions.	Water	193-198	activation induced cytidine deaminase	Homo sapiens	86-89
9288180-1	1997	BACKGROUND: Antioxidant enzymes (AEs), which catalyze the conversion of reactive oxygen species (ROS) to water, include catalase (CAT), manganese-containing superoxide dismutase (MnSOD), and copper and zinc-containing superoxide dismutase (CuZnSOD).	Water	105-110	superoxide dismutase 2	Homo sapiens	179-184
9265617-4	1997	To characterize the putative bioactive conformation, we have carried out a detailed structural analysis of a series of three conformationally constrained PTHrP-(1-34)-based mono- and bicyclic lactam-containing biologically active analogs: (III) The conformational properties were studied by circular dichroisim, nuclear magnetic resonance spectroscopy, distance geometry calculations, and molecular dynamic simulations in water/trifluoroethanol (TFE) mixtures.	Water	422-427	parathyroid hormone like hormone	Homo sapiens	154-159
9231793-16	1997	Leptin also altered salt and water metabolism under fasting conditions resulting in increased water intake and more dilute urine.	Water	29-34	leptin	Rattus norvegicus	0-6
9231793-16	1997	Leptin also altered salt and water metabolism under fasting conditions resulting in increased water intake and more dilute urine.	Water	94-99	leptin	Rattus norvegicus	0-6
9258458-2	1997	As part of our development of antibody pretargeting for cancer therapy, an investigation has been conducted to examine the stability of water solubilized, radioiodinated biotin derivatives toward biotinidase degradation in mouse and human serum.	Water	136-141	biotinidase	Mus musculus	196-207
9298595-2	1997	The short term effect of heavy water (2H2O) in intracellular pH (pHi) and phosphatidylcholine (PtdCho) turnover have been studied by 31P NMR spectroscopy in the perfused mouse liver metabolizing alanine.	Water	31-36	glucose-6-phosphate isomerase 1	Mus musculus	65-68
9247770-5	1997	Antisense significantly reduced (by about 50%) the volume of water drunk in response to intracerebroventricular (icv) renin or isoproterenol but did not reduce drinking in response to the physiological challenge of icv angiotensin II, icv carbachol, intravenous hypertonic saline, water deprivation or subcutaneous injection of polyethylene glycol.	Water	61-66	renin	Rattus norvegicus	118-123
9195927-3	1997	Nodulin 26 (NOD 26), a member of the aquaporin (AQP) water channel family, is a major protein component of the SM.	Water	53-58	nodulin-26	Glycine max	0-10
9195927-3	1997	Nodulin 26 (NOD 26), a member of the aquaporin (AQP) water channel family, is a major protein component of the SM.	Water	53-58	nodulin-26	Glycine max	12-18
9195927-4	1997	Expression of NOD 26 in Xenopus oocytes gave a mercury-sensitive increase in osmotic water permeability (Pf).	Water	85-90	nodulin-26	Glycine max	14-20
9195927-5	1997	To define the biophysical properties of NOD 26 water channels in their native membranes, symbiosomes were isolated from soybean root nodules and the SM separated as vesicles from the bacteria.	Water	47-52	nodulin-26	Glycine max	40-46
9195927-10	1997	Diffusive water permeability (Pd) was 0.0024 +/- 0.0002 cm/s, and the resulting Pf to Pd ratio was 18.3, indicating that water crosses the SM in single file fashion via the NOD 26 water channel.	Water	121-126	nodulin-26	Glycine max	173-179
9195927-10	1997	Diffusive water permeability (Pd) was 0.0024 +/- 0.0002 cm/s, and the resulting Pf to Pd ratio was 18.3, indicating that water crosses the SM in single file fashion via the NOD 26 water channel.	Water	121-126	nodulin-26	Glycine max	173-179
9195927-12	1997	Overall, we conclude that NOD 26 acts as a water channel with a single channel conductance that is 30-fold lower than AQP 1.	Water	43-48	nodulin-26	Glycine max	26-32
7638803-10	1995	Sniff PDI was 103 (21) cm H2O and was positively correlated with grip strength and cardiac output (Spearman rank correlation coefficients 0.527 and 0.451, respectively).	Water	26-29	prolyl 4-hydroxylase subunit beta	Homo sapiens	6-9
7759552-6	1995	The Bph-rp cDNA was expressed in Escherichia coli, and after purification, the recombinant protein was able to degrade p-nitrophenylbutyrate, a water-soluble substrate commonly used for assaying serine hydrolases.	Water	144-149	biphenyl hydrolase like	Homo sapiens	4-10
7756271-0	1995	A poly(ethylene glycol) water-soluble conjugate of porin: refolding to the native state.	Water	24-29	voltage dependent anion channel 1	Homo sapiens	51-56
7537730-0	1995	cAMP-dependent phosphorylation stimulates water permeability of aquaporin-collecting duct water channel protein expressed in Xenopus oocytes.	Water	42-47	aquaporin 2 L homeolog	Xenopus laevis	64-89
7537730-1	1995	Among water channel proteins (aquaporins), aquaporin-collecting duct (AQP-CD) is the vasopressin-regulated water channel.	Water	6-11	aquaporin 2 L homeolog	Xenopus laevis	43-68
7537730-1	1995	Among water channel proteins (aquaporins), aquaporin-collecting duct (AQP-CD) is the vasopressin-regulated water channel.	Water	6-11	aquaporin 2 L homeolog	Xenopus laevis	70-76
7537730-1	1995	Among water channel proteins (aquaporins), aquaporin-collecting duct (AQP-CD) is the vasopressin-regulated water channel.	Water	6-11	arginine vasopressin S homeolog	Xenopus laevis	85-96
7537730-2	1995	Vasopressin causes cAMP production in the renal collecting duct cells, and this is believed to lead to exocytic insertion of water channel into the apical membrane (shuttle hypothesis).	Water	125-130	arginine vasopressin S homeolog	Xenopus laevis	0-11
7537730-5	1995	In Xenopus oocytes injected with wild-type or mutated AQP-CD cRNAs, osmotic water permeability (Pf) was 4.8-7.7 times higher than Pf of water-injected oocytes.	Water	76-81	aquaporin 2 L homeolog	Xenopus laevis	54-60
7537730-5	1995	In Xenopus oocytes injected with wild-type or mutated AQP-CD cRNAs, osmotic water permeability (Pf) was 4.8-7.7 times higher than Pf of water-injected oocytes.	Water	136-141	aquaporin 2 L homeolog	Xenopus laevis	54-60
7537730-10	1995	Our data suggest that cAMP stimulates water permeability of AQP-CD by phosphorylation.	Water	38-43	aquaporin 2 L homeolog	Xenopus laevis	60-66
7537730-11	1995	This process may contribute to the vasopressin-regulated water permeability of collecting duct in addition to the apical insertion of AQP-CD by exocytosis.	Water	57-62	arginine vasopressin S homeolog	Xenopus laevis	35-46
7620095-8	1995	It was concluded that, in rat inner medulla: (1) aldose reductase mRNA abundance varies with changes in water balance or dietary protein, whereas sorbitol dehydrogenase and taurine cotransporter mRNA do not; and (2) heat shock protein-70 mRNA abundance is not increased during acute osmotic stress.	Water	104-109	aldo-keto reductase family 1 member B1	Rattus norvegicus	49-65
7718244-1	1995	The binding site of the dopamine D2 receptor, like that of other homologous G protein-coupled receptors, is contained within a water-accessible crevice formed among its seven membrane-spanning segments.	Water	127-132	dopamine receptor D2	Homo sapiens	24-44
7777612-1	1995	Intracerebroventricular (ICV) infusion of basic fibroblast growth factor (FGF-2) at 50 ng/h for 5 days in male BALB/c mice suppressed the daily intakes of water and food (n = 4).	Water	155-160	fibroblast growth factor 2	Mus musculus	42-72
7777612-1	1995	Intracerebroventricular (ICV) infusion of basic fibroblast growth factor (FGF-2) at 50 ng/h for 5 days in male BALB/c mice suppressed the daily intakes of water and food (n = 4).	Water	155-160	fibroblast growth factor 2	Mus musculus	74-79
7882325-4	1995	A dose-response relationship was observed between the long-term arsenic exposure from drinking artesian well water and the incidence of lung cancer, bladder cancer, and cancers of all sites combined after adjustment for age, sex, and cigarette smoking through Cox"s proportional hazards regression analysis.	Water	109-114	cytochrome c oxidase subunit 8A	Homo sapiens	260-263
7893740-2	1995	SP-B presented a very stable conformation in all the assayed ACN/water mixtures and in TFE/water mixtures containing until 70% TFE, showing around 40% alpha-helix.	Water	65-70	surfactant protein B	Homo sapiens	0-4
7893740-2	1995	SP-B presented a very stable conformation in all the assayed ACN/water mixtures and in TFE/water mixtures containing until 70% TFE, showing around 40% alpha-helix.	Water	91-96	surfactant protein B	Homo sapiens	0-4
7775017-2	1995	Solid ovalbumin in granules with 11% of water was heated at 100 degrees C in closed and nonclosed ampules.	Water	40-45	ovalbumin	Bos taurus	6-15
7746497-3	1995	Three days of water deprivation significantly increased plasma arginine vasopressin and markedly potentiated the expression of PACAP mRNA in ARC.	Water	14-19	adenylate cyclase activating polypeptide 1	Rattus norvegicus	127-132
7741532-6	1995	Subcutaneous infusion of ACTH (Synacthen) at 2.8 micrograms/day for 7 days by mini-osmotic pump increased sodium intake five-fold and water intake three- or four-fold.	Water	134-139	pro-opiomelanocortin-alpha	Mus musculus	25-29
7711107-0	1995	Directed N-terminal elongation of unprotected peptides catalyzed by cathepsin C in water.	Water	83-88	cathepsin C	Homo sapiens	68-79
7711107-1	1995	N-terminal chain extension of unprotected amino acid amides and peptides with dipeptide amides using Cathepsin C (dipeptidyl aminopeptidase I, EC 3.4.14.1)-mediated reverse proteolysis in water was studied.	Water	188-193	cathepsin C	Homo sapiens	101-112
7744285-1	1995	The study of general toxicological mechanism of acetone cyanhydrin and cyanides provided the data for reconsideration of their MACs in the water which is recommended at the level of 0.035 mg/l (as CN for each substance alone and both together).	Water	139-144	myristoylated alanine rich protein kinase C substrate	Homo sapiens	127-131
7529263-3	1995	To accomplish this goal, we have developed a fluorescence-based ELISA method and have used it to quantitate Aquaporin-CHIP (AQP-CHIP) water channel protein in rat kidney tubules.	Water	134-139	aquaporin 1	Rattus norvegicus	108-122
7529263-3	1995	To accomplish this goal, we have developed a fluorescence-based ELISA method and have used it to quantitate Aquaporin-CHIP (AQP-CHIP) water channel protein in rat kidney tubules.	Water	134-139	aquaporin 1	Rattus norvegicus	124-132
7529263-10	1995	Based on the unit water conductance of single CHIP molecules, our calculations show that the content of AQP-CHIP is sufficient to explain water permeability measured in isolated proximal tubules and DTL segments.	Water	18-23	aquaporin 1	Rattus norvegicus	104-112
7529263-10	1995	Based on the unit water conductance of single CHIP molecules, our calculations show that the content of AQP-CHIP is sufficient to explain water permeability measured in isolated proximal tubules and DTL segments.	Water	138-143	aquaporin 1	Rattus norvegicus	104-112
7705967-6	1994	Our results demonstrate that the toxicity for target cells of streptonigrin conjugated to specific IgG was 25 times higher than that of the initial water soluble form of antibiotic.	Water	148-153	immunoglobulin heavy variable V1-62	Mus musculus	99-102
7977858-1	1994	After exposure of tilapia for 7 days to low-pH water, plasma thyrotropin-releasing hormone (TRH) levels were elevated, and the melanocyte-stimulating hormone (MSH) cells in the pituitary pars intermedia had increased in size and showed enhanced synthetic and secretory activity.	Water	47-52	thyrotropin releasing hormone	Homo sapiens	92-95
7820672-2	1994	Discrimination of 0.18% saline from pure water was associated with significantly increased rCBF values in the thalamus, the insular cortex, the anterior cingulate gyrus, the parahippocampal gyrus, the lingual gyrus, the caudate nucleus, and the temporal gyri.	Water	41-46	CCAAT/enhancer binding protein zeta	Rattus norvegicus	91-95
7943311-0	1994	Altered expression of GLUT-1 and GLUT-3 glucose transporters in neurohypophysis of water-deprived or diabetic rats.	Water	83-88	solute carrier family 2 member 1	Rattus norvegicus	22-28
7833828-3	1994	Although CD spectrum of CsA in ethanol/water was indicative of the beta-turn structure rather than the beta-sheet structure of the polypeptide chain, the temperature-dependent structural changes were undetectable by CD spectroscopy.	Water	39-44	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	24-27
7837036-1	1994	The Walden Product, the product of viscosity (eta 0) and conductivity at infinite dilution of a solution (lambda 0), provides a measurement of the water-structuring activity of the solute.	Water	147-152	endothelin receptor type A	Homo sapiens	46-49
8075144-1	1994	Changes of infrared absorbance of sarcoplasmic reticulum Ca(2+)-ATPase (EC 3.6.1.38) associated with partial reactions of its catalytic cycle were investigated in the region from 1800 to 950 cm-1 in H2O and 2H2O.	Water	199-202	dynein axonemal heavy chain 8	Homo sapiens	64-70
7968838-7	1994	The beam hardening with depth in water, i.e., the value of eta, was readily determined but found to be clinically insignificant.	Water	33-38	endothelin receptor type A	Homo sapiens	59-62
18507712-2	2009	The results demonstrate that exogenous administration of H(2)O(2) and 1-methyl, 4-phenyl, pyridinium ion (MPP(+)) significantly decreased cell viability in SH-SY5Y cultured cells.	Water	57-62	M-phase phosphoprotein 6	Homo sapiens	106-109
7515568-7	1994	The results support the notion that PGE2 modulates water and solute transport through the EP3 receptor in specific structures of the kidney.	Water	51-56	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	90-93
20001913-0	2009	The dispersion of water proton spin-lattice relaxation rates in aqueous human protein HC (alpha1-microglobulin) solutions.	Water	18-23	alpha-1-microglobulin/bikunin precursor	Homo sapiens	78-88
8083813-2	1994	The tachykinin agonists substance P, [MePhe7]neurokinin B and [beta-Ala8]neurokinin A (4-10) all promoted defecation and increased faecal water content, the last compound being over ten times more potent than the other two (intraperitoneal dose inducing the excretion of 1 g faeces dry weight = 6.7 micrograms kg-1).	Water	138-143	tachykinin precursor 3	Rattus norvegicus	45-57
20001913-2	2009	The (1)H NMRD data have revealed the complex nature of the water/protein HC system resulting from the co-existence of monomer and dimer forms of the protein in solution as well as the presence of oligosaccharides linked to the polypeptide chain.	Water	59-64	alpha-1-microglobulin/bikunin precursor	Homo sapiens	65-75
20001913-3	2009	A comparison of the average correlation time values &lt;tau (c)&gt; obtained from the model-free fits with the values predicted on the basis of hydrodynamic tau (r) theory, suggests that the dynamics in solution state is governed mainly by the dimer form of the protein HC (the dominant contribution to the water proton-spin lattice relaxation comes from exchanging protons from the surface of the dimer).	Water	307-312	alpha-1-microglobulin/bikunin precursor	Homo sapiens	262-272
8126693-2	1994	The first water-soluble ACAT inhibitor with lipid-regulating activity.	Water	10-15	sterol O-acyltransferase 1	Homo sapiens	24-28
20001913-4	2009	The existence of small number of oligomeric forms of the protein HC in solutions is postulated because of the two-step shape of water proton spin-lattice relaxation rate dispersion profiles.	Water	128-133	alpha-1-microglobulin/bikunin precursor	Homo sapiens	57-67
18563875-6	2008	The calculations show that azole binding is a stepwise mechanism whereby first the water molecule from the resting state of P450 is released from the sixth binding site of the heme to create a pentacoordinated active site followed by coordination of the azole nitrogen to the heme iron.	Water	83-88	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	124-128
7509789-1	1994	Two mercurial-inhibitable water-transporting proteins have been identified: CHIP28, an erythrocyte water channel also expressed in kidney tubules and selected extrarenal epithelia, and WCH-CD, a kidney collecting duct water channel.	Water	26-31	aquaporin 1	Rattus norvegicus	76-82
18563875-9	2008	Thus, we show that release of a water molecule from the resting state of P450 enzymes to create a pentacoordinated heme will lead to a doublet to quartet spin state crossing at an Fe-OH(2) distance of approximately 3.0 A, while the azole substitution process takes place at shorter distances.	Water	32-37	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	73-77
19360954-9	2008	Water contact angles on thiophenyl ester surfaces were found to decrease after NCL reaction with the cysteine-lissamine conjugate, whereas surfaces treated with the same buffer solution containing an unreactive alanine-lissamine conjugate showed no significant changes in contact angle, indicating that thioester hydrolysis is not significant during the course of the reaction.	Water	0-5	nucleolin	Homo sapiens	79-82
8021041-7	1994	A water-based SnF2 preparation containing strongly complexed stannous ions does not form a surface coating on dentine in vitro suggesting that this preparation may not be optimal for treating hypersensitivity.	Water	2-7	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	14-18
19006294-2	2008	The reaction of Ni(ClO(4))(2).6H(2)O with paoH and NBu(n)(4)N(3) in H(2)O/MeCN in the presence of NEt(3), gave 1 in 65% yield.	Water	31-36	spermine oxidase	Homo sapiens	42-46
8003969-4	1994	A computer model of P44 was built and its stability was studied by molecular dynamics simulation with explicit water.	Water	111-116	interferon induced protein 44	Homo sapiens	20-23
19006294-3	2008	Complex 2 was obtained in 60% yield from the reaction of NiCl(2).6H(2)O with paoH and NaN(3) in H(2)O/MeCN in the presence of NaOH.	Water	66-71	spermine oxidase	Homo sapiens	77-81
19074884-13	2008	In a low-selenium population, SOD2-Ala16+ men homozygous for SEPP1-Ala234 are at an increased risk of prostate cancer/aggressive prostate cancer especially if ever-smokers, because they are likely to produce more mitochondrial H(2)O(2) that they cannot remove, thereby promoting prostate tumor cell proliferation and migration.	Water	227-232	superoxide dismutase 2	Homo sapiens	30-34
8296774-1	1994	The relation between aluminum, fluorine, calcium, and pH in drinking water and the risk for cognitive impairment was studied using data collected in 1988-1989 in a population-based survey of 3,777 French men and women aged 65 years and older (the Paquid study).	Water	69-74	phenylalanine hydroxylase	Homo sapiens	54-56
19002319-1	2008	The preliminary results presented here show that gamma-irradiation of ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([C4mim][PF6]) markedly decreases Sr2+ partitioning in the crown ether/[C4mim][PF6] extraction phase due to the competition between radiation-generated H+ and Sr2+ to interact with the crown ether, however, washing irradiated [C4mim][PF6] with water gives a simple way of recycling the ionic liquid.	Water	375-380	sperm associated antigen 17	Homo sapiens	140-143
20641737-8	2004	Gd-Fullerenols (Gd@C82(OH)40) are water-soluble Gd endohedral metallofullerenes used with in vivo MRI (8).	Water	34-39	complement C8 beta chain	Homo sapiens	19-22
18988797-2	2008	We have previously reported that in normal cholangiocytes a subset of vesicles contain three proteins (ie, the water channel AQP1, the chloride channel CFTR, and the anion exchanger AE2) that account for ion-driven water transport.	Water	111-116	aquaporin 1	Rattus norvegicus	125-129
18988797-2	2008	We have previously reported that in normal cholangiocytes a subset of vesicles contain three proteins (ie, the water channel AQP1, the chloride channel CFTR, and the anion exchanger AE2) that account for ion-driven water transport.	Water	215-220	aquaporin 1	Rattus norvegicus	125-129
18773979-6	2008	In the second case, corresponding to the GTP hydrolysis by EF-Tu alone, the side chain of His85 stays away from the active site, and the chemical reaction GTP+H(2)O--&gt;GDP+Pi proceeds without participation of the histidine but through water molecules.	Water	159-164	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	59-64
18773979-6	2008	In the second case, corresponding to the GTP hydrolysis by EF-Tu alone, the side chain of His85 stays away from the active site, and the chemical reaction GTP+H(2)O--&gt;GDP+Pi proceeds without participation of the histidine but through water molecules.	Water	237-242	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	59-64
18687780-7	2008	Delivery of AT1R AS into the SFO attenuated water intake, ACTH, and CORT after isoproterenol, whereas similar treatment in the OVLT had no effect.	Water	44-49	angiotensin II receptor type 1	Homo sapiens	12-16
18988736-6	2008	It is proposed that, in both cases, a protonated basic residue (Arg-37 in the case of human UroD; Lys-93 in the case of yeast ODCase) furnishes a counterion that helps the scissile carboxylate group of the substrate leave water and enter a relatively nonpolar environment, stabilizes the incipient carbanion generated by the departure of CO(2), and supplies the proton that takes its place.	Water	222-227	uroporphyrinogen decarboxylase	Homo sapiens	92-96
18854895-1	2008	A new polyoxovanadate [Zn2(dien)3][[Zn(dien)]2As4V16O42(H2O)] x 3H2O (1, dien = diethylenetriamine) has been hydrothermally synthesized and structurally characterized by EA, IR, TGA, magnetic measurement and single crystal X-ray diffraction.	Water	56-59	T-box transcription factor 1	Homo sapiens	178-181
20648227-6	2008	The wavenumber of the PheCN nuC N band was strongly dependent on the polarity of its environment, when the solvent was changed from H(2)O to THF it decreased by 8 cm(-1).	Water	132-137	nucleobindin 1	Homo sapiens	28-31
19267975-12	2008	Thereafter the expression of the cleaved-caspase-3 decreased with 600 micromol/L H(2)O(2) and with 800 micromol/L H(2)O(2) the expression of cleaved-caspase-3 was weak.	Water	81-86	caspase 3	Rattus norvegicus	41-50
19267975-12	2008	Thereafter the expression of the cleaved-caspase-3 decreased with 600 micromol/L H(2)O(2) and with 800 micromol/L H(2)O(2) the expression of cleaved-caspase-3 was weak.	Water	81-86	caspase 3	Rattus norvegicus	149-158
19267975-12	2008	Thereafter the expression of the cleaved-caspase-3 decreased with 600 micromol/L H(2)O(2) and with 800 micromol/L H(2)O(2) the expression of cleaved-caspase-3 was weak.	Water	114-119	caspase 3	Rattus norvegicus	41-50
19267975-12	2008	Thereafter the expression of the cleaved-caspase-3 decreased with 600 micromol/L H(2)O(2) and with 800 micromol/L H(2)O(2) the expression of cleaved-caspase-3 was weak.	Water	114-119	caspase 3	Rattus norvegicus	149-158
18706888-0	2008	Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice.	Water	19-24	regucalcin	Mus musculus	93-98
18706888-0	2008	Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice.	Water	19-24	regucalcin	Mus musculus	99-102
18789935-4	2008	Expression of CD59 by RT-PCR and Western blot was drastically reduced in the animals that were fed with alcohol, nicotine and alcohol and nicotine compared to those fed with water alone and this was associated with exacerbation of CNV.	Water	174-179	CD59 molecule	Rattus norvegicus	14-18
17998215-1	2008	OBJECTIVES: MUC5B contains sulfated and sialylated oligosaccharides that sequester water required for moisturising the oral mucosa.	Water	83-88	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	12-17
18778097-6	2008	When the cellulose I-EDA complex was immersed in methanol or water at room temperature, cellulose III I or I beta was obtained, respectively.	Water	61-66	G protein-coupled receptor 149	Homo sapiens	19-24
18809654-0	2008	A polymer-type water-soluble peptidoglycan exhibited both Toll-like receptor 2- and NOD2-agonistic activities, resulting in synergistic activation of human monocytic cells.	Water	15-20	nucleotide binding oligomerization domain containing 2	Homo sapiens	84-88
18809654-4	2008	The water-soluble PGN polymer, SEPS, exhibited considerably stronger activities to induce pro-inflammatory cytokines than parent PGNs and the PGN monomer, SEPS-M. Short interference RNA targeting TLR2 and NOD2 markedly reduced the activities of SEPS.	Water	4-9	nucleotide binding oligomerization domain containing 2	Homo sapiens	205-209
18694844-5	2008	Presently, P10 immunization and chemotherapy were associated in an attempt to improve antifungal treatment in Balb/c mice made anergic by adding dexamethasone to the drinking water.	Water	175-180	S100 calcium binding protein A10 (calpactin)	Mus musculus	11-14
9227605-1	1997	Experiments were performed in rats to test the hypothesis that adrenal mRNA levels of tyrosine hydroxylase (TH) and the norepinephrine transporter (NET) would be modified by water deprivation via activation of the sympathetic nervous system.	Water	174-179	tyrosine hydroxylase	Rattus norvegicus	86-106
18794864-3	2008	Using an interactive computational-experimental approach, we show that sodium sensitivity of Kir channels involves the side chains of an aspartate and a histidine located across from each other in a crucial loop in the cytosolic domain, as well as the backbone carbonyls of two more residues and a water molecule.	Water	298-303	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	93-96
9227605-1	1997	Experiments were performed in rats to test the hypothesis that adrenal mRNA levels of tyrosine hydroxylase (TH) and the norepinephrine transporter (NET) would be modified by water deprivation via activation of the sympathetic nervous system.	Water	174-179	tyrosine hydroxylase	Rattus norvegicus	108-110
9227605-3	1997	Adrenal TH mRNA was higher (P &lt; 0.001) in water-deprived (921 +/- 39 fg/microgram total RNA) compared with the water-replete rats (657 +/- 45 fg/microgram total RNA).	Water	45-50	tyrosine hydroxylase	Rattus norvegicus	8-10
18600471-3	2008	Even though it carries out the opposite of the water splitting reaction, P450 may share similarities to PSII in proton delivery networks, oxygen and water access channels, and consecutive electron transfer processes.	Water	47-52	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	73-77
9153196-5	1997	Inactive inclusion bodies were collected and refolded, and active enzyme was purified; the resulting mCA IV was used to characterize the catalysis of CO2 hydration using stopped flow spectrophotometry and 18O exchange between CO2 and water.	Water	234-239	carbonic anhydrase 4	Mus musculus	101-107
9153196-6	1997	Unlike previously studied isozymes in this class of carbonic anhydrase, the pH profile for kcat for hydration of CO2 catalyzed by mCA IV could not be described by a single ionization, suggesting multiple proton transfer pathways between the zinc-bound water molecule and solution.	Water	252-257	carbonic anhydrase 4	Mus musculus	130-136
9153196-7	1997	A role for His64 in transferring protons between the zinc-bound water and solution was confirmed by the 100-fold lower activity of the mutant of mCA IV containing the replacement His64 --&gt; Ala.	Water	64-69	carbonic anhydrase 4	Mus musculus	145-151
9153196-10	1997	A pKa of 6.6 was estimated for the zinc-bound water molecule in mCA IV.	Water	46-51	carbonic anhydrase 4	Mus musculus	64-70
18600471-3	2008	Even though it carries out the opposite of the water splitting reaction, P450 may share similarities to PSII in proton delivery networks, oxygen and water access channels, and consecutive electron transfer processes.	Water	149-154	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	73-77
18709442-1	2008	The extrinsic PsbO subunit of the water-oxidizing photosystem II (PSII) complex is represented by two isoforms in Arabidopsis thaliana, namely PsbO1 and PsbO2.	Water	34-39	PS II oxygen-evolving complex 1	Arabidopsis thaliana	143-148
9148905-0	1997	Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membrane.	Water	26-31	aquaporin 1	Rattus norvegicus	78-89
9148905-3	1997	We have previously shown that secretin stimulates exocytosis in cholangiocytes and that these cells transport water mainly via the water channel aquaporin-1 (AQP1).	Water	110-115	aquaporin 1	Rattus norvegicus	145-156
9148905-3	1997	We have previously shown that secretin stimulates exocytosis in cholangiocytes and that these cells transport water mainly via the water channel aquaporin-1 (AQP1).	Water	110-115	aquaporin 1	Rattus norvegicus	158-162
9148905-3	1997	We have previously shown that secretin stimulates exocytosis in cholangiocytes and that these cells transport water mainly via the water channel aquaporin-1 (AQP1).	Water	131-136	aquaporin 1	Rattus norvegicus	145-156
9148905-3	1997	We have previously shown that secretin stimulates exocytosis in cholangiocytes and that these cells transport water mainly via the water channel aquaporin-1 (AQP1).	Water	131-136	aquaporin 1	Rattus norvegicus	158-162
9148905-4	1997	In this study, we tested the hypothesis that secretin promotes osmotic water movement in cholangiocytes by inducing the exocytic insertion of AQP1 into plasma membranes.	Water	71-76	aquaporin 1	Rattus norvegicus	142-146
18709442-1	2008	The extrinsic PsbO subunit of the water-oxidizing photosystem II (PSII) complex is represented by two isoforms in Arabidopsis thaliana, namely PsbO1 and PsbO2.	Water	34-39	photosystem II subunit O-2	Arabidopsis thaliana	153-158
18712914-1	2008	Mono- and bilayer adsorption of H2O molecules on TiO2 and SnO 2 (110) surfaces has been investigated using static planewave density functional theory (PW DFT) simulations.	Water	32-35	strawberry notch homolog 1	Homo sapiens	58-61
9086296-7	1997	The high concentration of MG1 in resting saliva in SS, may be explained by the concentration effect, or alternatively by the low water retaining capacity, which may play an important pathogenic role in xerostomia of SS.	Water	129-134	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	26-29
8304410-3	1994	In addition, the erythrocyte and proximal tubule water channel CHIP28 is present on the plasma membrane of proximal tubule cells and may undergo endocytosis so that it is incorporated in lysosomes.	Water	49-54	aquaporin 1	Rattus norvegicus	63-69
18853806-12	2008	These results indicate that the water samples contain substances that bind to AhR, and these substances contribute to ER signaling through AhR activation in the yeast reporter strain.	Water	32-37	aryl hydrocarbon receptor	Homo sapiens	78-81
8253212-3	1993	Our data support the notion that the terminal beta 1,6-linked GlcNAc unit of GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc may interact with the reducing end GlcNAc unit intramolecularly in water solution.	Water	195-200	tubulin beta 3 class III	Homo sapiens	100-108
9116008-3	1997	The conformation of the three cyclic antagonist analogs of parathyroid hormone-related protein (PTHrP)-(7-34) [[Lys13,Asp17]PTHrP-(7-34)NH2,[Lys26,Asp30 ]PTHrP-(7-34)NH2,[Lys13,Asp17,Lys26, Asp30]PTHrP-(7-34)NH2] is investigated by CD, NMR, and extensive computer simulations in aqueous solution and a TFE:water mixture.	Water	306-311	parathyroid hormone like hormone	Homo sapiens	59-94
9116008-3	1997	The conformation of the three cyclic antagonist analogs of parathyroid hormone-related protein (PTHrP)-(7-34) [[Lys13,Asp17]PTHrP-(7-34)NH2,[Lys26,Asp30 ]PTHrP-(7-34)NH2,[Lys13,Asp17,Lys26, Asp30]PTHrP-(7-34)NH2] is investigated by CD, NMR, and extensive computer simulations in aqueous solution and a TFE:water mixture.	Water	306-311	parathyroid hormone like hormone	Homo sapiens	96-101
8256903-8	1993	For the group as a whole, twitch Pdi fell from 28.9 +/- 3.7 cm H2O during control to 23.9 +/- 5.1 cm H2O at 10 min after exercise (p &lt; 0.005).	Water	63-66	prolyl 4-hydroxylase subunit beta	Homo sapiens	33-36
18853806-12	2008	These results indicate that the water samples contain substances that bind to AhR, and these substances contribute to ER signaling through AhR activation in the yeast reporter strain.	Water	32-37	aryl hydrocarbon receptor	Homo sapiens	139-142
18617528-9	2008	In contrast, AMP-activated protein kinase (AMPK) was progressively activated in H(2)O(2)-treated cells.	Water	80-85	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	43-47
8256903-8	1993	For the group as a whole, twitch Pdi fell from 28.9 +/- 3.7 cm H2O during control to 23.9 +/- 5.1 cm H2O at 10 min after exercise (p &lt; 0.005).	Water	101-104	prolyl 4-hydroxylase subunit beta	Homo sapiens	33-36
8256903-9	1993	The fall in twitch Pdi was due to a significant decrease in twitch esophageal pressure from 19.6 +/- 4.3 cm H2O during control to 15.5 +/- 4.9 cm H2O (p &lt; 0.001).	Water	108-111	prolyl 4-hydroxylase subunit beta	Homo sapiens	19-22
8256903-9	1993	The fall in twitch Pdi was due to a significant decrease in twitch esophageal pressure from 19.6 +/- 4.3 cm H2O during control to 15.5 +/- 4.9 cm H2O (p &lt; 0.001).	Water	146-149	prolyl 4-hydroxylase subunit beta	Homo sapiens	19-22
9054574-8	1997	Additional positive charges in the active site of CA IV stabilize anions as indicated by a decreased pKa for the Zn-bound water compared to CA II (6.2 vs 6.9), as well as lower inhibition constants for a variety of anions, including halides, sulfate, formate, acetate, and bicarbonate.	Water	122-127	carbonic anhydrase 4	Homo sapiens	50-55
9141650-5	1997	These results suggest that neurokinin B is involved in the regulation of MCH neuron activity via the NK3 receptor; they provide new bases for further investigations on MCH role in the control of food and water intake.	Water	204-209	tachykinin precursor 3	Rattus norvegicus	27-39
18602969-1	2008	UNLABELLED: In the adult, cerebrospinal fluid (CSF) is produced by the actions of numerous transporters and enzymes creating ion gradients that drive the entry of water into the ventricles via the aquaporin-1 water channels (AQP1).	Water	163-168	aquaporin 1	Rattus norvegicus	225-229
21245221-8	1997	In addition to aquaporin phosphorylation, other mechanisms that target aquaporin function are used by living cells to regulate their membrane water permeability.	Water	142-147	aquaporin	Xenopus laevis	15-24
21245221-8	1997	In addition to aquaporin phosphorylation, other mechanisms that target aquaporin function are used by living cells to regulate their membrane water permeability.	Water	142-147	aquaporin	Xenopus laevis	71-80
21245221-9	1997	These are the fine control of aquaporin gene expression and, in animal cells only, the regulated trafficking of water channel-containing vesicles.	Water	112-117	aquaporin	Xenopus laevis	30-39
21245221-14	1997	The fine tuning of TIP aquaporin activity may help control the kinetics and amplitude of osmotic water flows across the tonoplast to achieve proper cytoplasm osmoregulation and control of vacuolar volume.	Water	97-102	aquaporin	Xenopus laevis	23-32
8194083-11	1993	Cosedimentation of water-soluble S-100 protein with the synaptosomal fraction during isolation was insignificant.	Water	19-24	S100 calcium binding protein A1	Mus musculus	33-38
8224646-0	1993	Peptide YY is a physiological regulator of water and electrolyte absorption in the canine small bowel in vivo.	Water	43-48	peptide YY	Canis lupus familiaris	0-10
18602969-1	2008	UNLABELLED: In the adult, cerebrospinal fluid (CSF) is produced by the actions of numerous transporters and enzymes creating ion gradients that drive the entry of water into the ventricles via the aquaporin-1 water channels (AQP1).	Water	209-214	aquaporin 1	Rattus norvegicus	225-229
8224646-7	1993	PYY infusion resulted in a dose-dependent increase in water and electrolyte absorption at all doses in both the jejunum and ileum.	Water	54-59	peptide YY	Canis lupus familiaris	0-3
18690748-4	2008	The X-ray crystal structure of E. coli Sdh shows that residues SdhB (G227), SdhC (D95), and SdhC (E101) are located at or near the entrance of a water channel that has been proposed to function as a proton wire connecting the cytoplasm to the quinone binding site.	Water	145-150	sorbitol dehydrogenase	Gallus gallus	39-42
8224646-9	1993	CONCLUSIONS: Physiological concentrations of PYY produced an increase in small bowel absorption of water and electrolytes in vivo.	Water	99-104	peptide YY	Canis lupus familiaris	45-48
9032207-5	1997	Mean twitch transdiaphragmatic pressure (Tw Pdi) was 19.7 cm H2O 25 min after a control run and 20.5 cm H2O at the same time after MIV [corrected].	Water	61-64	prolyl 4-hydroxylase subunit beta	Homo sapiens	44-47
9048343-2	1997	The autosomal recessive form of NDI is caused by mutations in the AQP2 gene, encoding the vasopressin-regulated water channel of the kidney collecting duct.	Water	112-117	arginine vasopressin S homeolog	Xenopus laevis	90-101
18690748-5	2008	However, the pig and chicken Sdh enzymes show an alternative entrance to the water channel via the conserved SdhD (Q78) residue.	Water	77-82	sorbitol dehydrogenase	Gallus gallus	29-32
8272411-1	1993	The effect of salts (KI, KBr, NaCl, KCl, KF, phosphate, and Na2SO4) on the stability of beta-galactosidase in aqueous solution was studied from the aspect of changes in water mobility.	Water	169-174	galactosidase beta 1	Homo sapiens	88-106
8272411-3	1993	At higher concentrations, those salts which had little effect on the spin-lattice relaxation time, T1, of water (KI, KBr, and KCl) continued to increase the inactivation rate of beta-galactosidase with increasing concentration, while those salts which decreased the T1 of water (KF, phosphate, and Na2SO4) decreased the inactivation rate.	Water	106-111	galactosidase beta 1	Homo sapiens	178-196
18690748-7	2008	We show that the observed water channel in the E. coli Sdh structure is the functional proton wire in vivo, while in vitro results indicate an alternative entrance for protons.	Water	26-31	sorbitol dehydrogenase	Gallus gallus	55-58
8272411-3	1993	At higher concentrations, those salts which had little effect on the spin-lattice relaxation time, T1, of water (KI, KBr, and KCl) continued to increase the inactivation rate of beta-galactosidase with increasing concentration, while those salts which decreased the T1 of water (KF, phosphate, and Na2SO4) decreased the inactivation rate.	Water	272-277	galactosidase beta 1	Homo sapiens	178-196
8272411-4	1993	It appeared that the decrease in water mobility caused by KF, phosphate, and Na2SO4 resulted in stabilization of beta-galactosidase.	Water	33-38	galactosidase beta 1	Homo sapiens	113-131
20408690-6	2008	In this article, the authors review simulations of water at the interface with hydrophilic SAMs.	Water	51-56	methionine adenosyltransferase 1A	Homo sapiens	91-95
8220068-4	1993	The T1/T2 ratio was also exploited indicating that even bulk water experiences anisotropic motions due to the gel formation.	Water	61-66	interleukin 1 receptor like 1	Homo sapiens	4-9
9012671-0	1997	Mechanism of cytochrome c oxidase-catalyzed reduction of dioxygen to water: evidence for peroxy and ferryl intermediates at room temperature.	Water	69-74	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	13-33
9039135-2	1997	To investigate the role of the renin-angiotensin system in the regulation of adrenal growth in deoxycorticosterone (DOC)-salt hypertensive rats, and the adrenal gene expression of angiotensin AT1 and AT2 receptors, three groups of uninephrectomized rats + DOC pellet + 0.9% NaCl were given water (DOC), losartan (DOC-L), or ramipril (DOC-R) by gavage.	Water	290-295	angiotensin II receptor, type 2	Rattus norvegicus	200-203
18654997-8	2008	Literature data reported a conserved pattern of hydrogen bonds between a single water molecule and three amino acid residues of the binding site in a series of crystallized FABP.	Water	80-85	fatty acid binding protein 2	Gallus gallus	173-177
9318556-6	1997	In addition, the elevation of haemolymph [Mg2+] by incubation in high-[Mg2+] water prevented the drop in pHi and the rise in lactate levels induced by anoxia.	Water	77-82	glucose-6-phosphate isomerase	Homo sapiens	105-108
19044834-1	2008	The salting out of methane by adding NaCl to water at 25 degrees C and 1 atm is investigated by calculating the work of cavity creation by means of scaled particle theory and the methane-solvent energy of attraction.	Water	45-50	cullin associated and neddylation dissociated 1	Homo sapiens	65-72
8996184-5	1997	of amisulpride were needed to block grooming behavior observed after a short period in water, a D1 receptor-mediated behavior.	Water	87-92	dopamine receptor D1	Mus musculus	96-107
9106141-7	1997	On out-of-phase spoiled gradient echo images, demonstration of signal void fat-water phase cancellation was present in all eight lesions in the seven patients who were imaged with this sequence.	Water	79-84	FAT atypical cadherin 1	Homo sapiens	75-78
8342133-9	1993	RESULTS: Inhibition of calmodulin resulted in an increase in net Na+ and water absorption and converted the gallbladder from a Cl- absorptive state.	Water	73-78	calmodulin-2	Canis lupus familiaris	23-33
18665315-0	2008	Electrodeposition of Ge, Si and Si x Ge 1-x from an air- and water-stable ionic liquid.	Water	61-66	enhancer of mRNA decapping 4	Homo sapiens	37-41
8396049-2	1993	Recently developed, Indigestible Dextrin (PF-C) is a low viscosity, water-soluble dietary fiber obtained by heating and enzyme-treatment of potato starch.	Water	68-73	complement factor properdin	Rattus norvegicus	42-46
9106141-13	1997	Consistent image quality and high conspicuity of fat-water phase cancellation interfaces renders out-of-phase imaging a reliable fat attenuating method to demonstrate the presence of fat in small angiomyolipomas.	Water	53-58	FAT atypical cadherin 1	Homo sapiens	49-52
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	98-103	endothelin receptor type A	Homo sapiens	94-97
9007993-5	1997	The chemical potential change on transferring the denatured RNase A from water to sorbitol solution is larger than that for the native protein, delta mu(2D) &gt; delta mu(2N), which is consistent with the effect of sorbitol on the free energy change of denaturation.	Water	73-78	ribonuclease A family member 1, pancreatic	Homo sapiens	60-67
9017859-6	1997	The proportions and densities of the 3 main constituents comprising the fat-free body (mineral, protein and water) are altered following SCI.	Water	108-113	FAT atypical cadherin 1	Homo sapiens	72-75
7685033-1	1993	Pores formed in the outer membrane of mitochondria by mitochondrial porin make it permeable to water-soluble metabolites smaller than approximately 5 kDa.	Water	95-100	voltage dependent anion channel 1	Homo sapiens	68-73
7687270-6	1993	The coinjection of an antisense oligonucleotide for CHIP28 protein, at an assumed &gt; 100-fold molar excess, with either cortex, medulla, or papilla mRNA reduced the expression of the water permeability by approximately 70, 100, and 30%, respectively.	Water	185-190	aquaporin 1	Rattus norvegicus	52-58
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	98-103	endothelin receptor type A	Homo sapiens	106-109
7687270-9	1993	These results suggest that multiple distinct water channels were expressed in oocytes injected with mRNA obtained from sections of rat kidney: (a) CHIP28 water channels in cortex and medulla, (b) cAMP-activated water channels in medulla, and (c) cAMP-insensitive water channels in papilla.	Water	45-50	aquaporin 1	Rattus norvegicus	147-153
7687270-9	1993	These results suggest that multiple distinct water channels were expressed in oocytes injected with mRNA obtained from sections of rat kidney: (a) CHIP28 water channels in cortex and medulla, (b) cAMP-activated water channels in medulla, and (c) cAMP-insensitive water channels in papilla.	Water	154-159	aquaporin 1	Rattus norvegicus	147-153
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	98-103	endothelin receptor type A	Homo sapiens	106-109
7687270-9	1993	These results suggest that multiple distinct water channels were expressed in oocytes injected with mRNA obtained from sections of rat kidney: (a) CHIP28 water channels in cortex and medulla, (b) cAMP-activated water channels in medulla, and (c) cAMP-insensitive water channels in papilla.	Water	154-159	aquaporin 1	Rattus norvegicus	147-153
7687270-9	1993	These results suggest that multiple distinct water channels were expressed in oocytes injected with mRNA obtained from sections of rat kidney: (a) CHIP28 water channels in cortex and medulla, (b) cAMP-activated water channels in medulla, and (c) cAMP-insensitive water channels in papilla.	Water	154-159	aquaporin 1	Rattus norvegicus	147-153
8997281-0	1996	In vivo inhibition of transcellular water channels (aquaporin-1) during acute peritoneal dialysis in rats.	Water	36-41	aquaporin 1	Rattus norvegicus	52-63
8997281-6	1996	Immunocytochemistry and immunoelectron microscopy revealed abundant AQP-1 labeling in capillary endothelium in peritoneal tissues, representing sites for HgCl2 inhibition of water transport.	Water	174-179	aquaporin 1	Rattus norvegicus	68-73
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	98-103	endothelin receptor type A	Homo sapiens	106-109
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	161-166	endothelin receptor type A	Homo sapiens	94-97
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	161-166	endothelin receptor type A	Homo sapiens	106-109
8997341-0	1996	Forebrain angiotensin type 1 receptors and parabrachial serotonin in the control of NaCl and water intake.	Water	93-98	angiotensin II receptor, type 1a	Rattus norvegicus	10-28
8506291-7	1993	Its presence in the choroid plexus suggests that CHIP28-mediated water transport contributes to secretion of cerebrospinal fluid.	Water	65-70	aquaporin 1	Rattus norvegicus	49-55
8506291-9	1993	These findings further establish the general physiologic role of CHIP28 as a water channel involved in reabsorption, osmoregulation, and secretion.	Water	77-82	aquaporin 1	Rattus norvegicus	65-71
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	161-166	endothelin receptor type A	Homo sapiens	106-109
8946804-9	1996	The solvent-water molecule forms two hydrogen bonds with peptide molecule involving NH of Val1 as an acceptor and another with CO of a symmetry related (1-x, y-1/2, 1/2 -z) delta Phe3 as a donor.	Water	12-17	dihydrolipoamide dehydrogenase	Homo sapiens	179-183
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	161-166	endothelin receptor type A	Homo sapiens	106-109
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	161-166	endothelin receptor type A	Homo sapiens	94-97
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	161-166	endothelin receptor type A	Homo sapiens	106-109
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	161-166	endothelin receptor type A	Homo sapiens	106-109
8958221-10	1996	Taken together, our data show that UT1 corresponds to the previously characterized vasopressin-regulated urea transporter in the apical membrane of the terminal IMCD which plays a critical role in renal water conservation.	Water	203-208	cytochrome P450, family 2, subfamily c, polypeptide 12	Rattus norvegicus	35-38
8504476-10	1993	Oral feeding of GTP and WEGT in drinking water also showed significant enhancement in the activities of glutathione S-transferase and NADP(H): quinone reductase in liver, small bowel, stomach and lung.	Water	41-46	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	134-141
18646878-2	2008	It is found that the diffusion constant of phospholipids showed the relation D approximately (eta water + eta oil) -0.85, where D is the diffusion constant, eta water is the viscosity of water, and eta oil is the viscosity of oil.	Water	161-166	endothelin receptor type A	Homo sapiens	106-109
18656971-3	2008	The experiments show that a long-range, double-layer repulsion acts between the mica (which is negatively charged) and an air bubble in water and in various electrolyte solutions at low concentration, thereby indicating that the air bubble surface is negatively charged.	Water	136-141	MHC class I polypeptide-related sequence A	Homo sapiens	80-84
8917652-4	1996	It was recognized that in addition to having the required pharmacophore (the 4-hydroxy group with hydrogen-bonding interaction with the two catalytic aspartic acid residues and the lactone moiety replacing the ubiquitous water molecule in the active site), these 5,6-dihydro-4-hydroxy-2-pyrones incorporated side chains at the C-6 position that appropriately extended into the S1" and S2" subsites of the enzyme active site.	Water	221-226	complement C6	Homo sapiens	327-330
18656971-4	2008	However, there is clear evidence that charge regulation occurs at the air-water interface to maintain a constant surface potential, and as a result of this, the charge at this interface changes from negative to positive as the bubble approaches the mica surface.	Water	74-79	MHC class I polypeptide-related sequence A	Homo sapiens	249-253
8918374-1	1996	Three members of the water channel (aquaporin) family are expressed in adult rat lung: CHIP28 (AQP-1), MIWC (AQP-4), and AQP-5.	Water	21-26	aquaporin 1	Rattus norvegicus	87-93
8918374-1	1996	Three members of the water channel (aquaporin) family are expressed in adult rat lung: CHIP28 (AQP-1), MIWC (AQP-4), and AQP-5.	Water	21-26	aquaporin 1	Rattus norvegicus	95-100
8321832-8	1993	We propose that inactivation of beta-galactosidase is due to formation of thermally denatured (unfolded) protein, which aggregates dependent on the water:protein ratio, either via noncovalent interactions at a high water:protein ratio in solution or via covalent interaction at a low water:protein ratio in the freeze-dried state.	Water	148-153	galactosidase beta 1	Homo sapiens	32-50
8321832-8	1993	We propose that inactivation of beta-galactosidase is due to formation of thermally denatured (unfolded) protein, which aggregates dependent on the water:protein ratio, either via noncovalent interactions at a high water:protein ratio in solution or via covalent interaction at a low water:protein ratio in the freeze-dried state.	Water	215-220	galactosidase beta 1	Homo sapiens	32-50
18767648-7	2008	The water effect seems to be influenced by the HO2/RO2 ratio.	Water	4-9	heme oxygenase 2	Homo sapiens	47-50
8321832-8	1993	We propose that inactivation of beta-galactosidase is due to formation of thermally denatured (unfolded) protein, which aggregates dependent on the water:protein ratio, either via noncovalent interactions at a high water:protein ratio in solution or via covalent interaction at a low water:protein ratio in the freeze-dried state.	Water	215-220	galactosidase beta 1	Homo sapiens	32-50
11666793-8	1996	[Mn(IV)(Me(3)TACN)(OMe)(3)](PF(6)) was found to catalyze the oxidation of water-soluble olefins using hydrogen peroxide as the oxidant in an aqueous medium.	Water	74-79	sperm associated antigen 17	Homo sapiens	28-33
18450590-8	2008	The immunostaining of the glial water channel aquaporin-4 was increased in the outer retina, whereas the immunostaining of the photoreceptor water channel aquaporin-1 disappeared.	Water	141-146	aquaporin 1	Rattus norvegicus	155-166
8904632-4	1996	We conclude that angiotensin II is secreted into proximal tubular fluid and, in the anaesthetized rat, is maintained at a concentration that inhibits sodium and water transport via AT1 receptors.	Water	161-166	angiotensin II receptor, type 1a	Rattus norvegicus	181-184
24193734-3	1996	A water-balance equation of the system which can be used in different climatic conditions was obtained and can be written as DeltaW=Q+PPTN-Et a ; where DeltaW is the variation of storage water in the bed (in mm), Q is the effluent wastewater (in mm), and PPTN is the total precipitation.	Water	2-7	endothelin receptor type A	Homo sapiens	139-143
8466933-3	1993	The height of Cys-344 above the phospholipid/water interface has been measured by resonance energy transfer for the ATPase reconstituted into bilayers containing fluorescein-labelled phosphatidylethanolamine; the height was found to be about 45 A.	Water	45-50	dynein axonemal heavy chain 8	Homo sapiens	116-122
8003705-3	1993	Treatment with TRH resulted in significantly increased hypothalamic vasopressin content in both euhydrated (i.e. given tap water ad libitum) and salt-loaded rats.	Water	123-128	thyrotropin releasing hormone	Rattus norvegicus	15-18
18434439-6	2008	Likewise, administration of either an AT1 receptor antagonist, losartan, or an NMDA receptor antagonist, MK-801, attenuated the increase in SVR and the decrease in CO in VR in response to either cocaine (losartan and MK-801) or startle with cold water (losartan) without altering either response in MR. We propose that the MnPO is responsible for greater SVR responses in VR and that AT1 and NMDA receptors play an important role in greater SVR responses in VR.	Water	246-251	angiotensin II receptor, type 1a	Rattus norvegicus	38-41
8459687-8	1993	Typically, a severely diabetic rabbit on a basal dose implant exhibited a transient hyperglycaemia after drinking sweetened water, which raised the blood glucose from 5.4 +/- 1.3 mmol l-1 to 14.0 +/- 0.5 mmol l-1 for 3 to 4.5 h. In the three test runs, the supplemental bolus of insulin from the silicone implant interrupted the expected rise in blood glucose at 6.1 +/- 2.2 mmol l-1 within 1 to 2 h, which then decreased to 3.0 +/- 0.2 mmol l-1 for 4 to 5 h before returning to the basal level.	Water	124-129	insulin	Oryctolagus cuniculus	279-286
8953214-7	1996	We found that a combination of the SPC/E water model and a revised GROMOS87 force field gives close agreement with experiment, while the same and other force fields in combination with SPC or TIP3P water did not reproduce the NMR data at all.	Water	41-46	surfactant protein C	Bos taurus	35-38
8953222-4	1996	The performance of this approach is demonstrated for the 13C-/15N-labeled Hck/SH2 dissolved in H2O.	Water	95-98	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
18540637-11	2008	Extended X-ray absorption fine structure (EXAFS) simulations indicate the average Fe-O/N bond length in Dfh is 2.13 A, consistent with a ligand geometry constructed by water and carboxylate oxygens most likely supplied in part by surface-exposed conserved acidic residues located on helix 1 and strand 1 in the structurally characterized frataxin orthologs.	Water	168-173	frataxin	Drosophila melanogaster	104-107
8887277-0	1996	Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney.	Water	10-15	heat shock protein family B (small) member 1	Rattus norvegicus	64-84
8887277-0	1996	Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney.	Water	29-34	heat shock protein family B (small) member 1	Rattus norvegicus	64-84
7679494-7	1993	Two other angiogenic molecules, basic fibroblast growth factor and tumor necrosis factor alpha, bind to 125I-labeled actin and can be crosslinked by a water-soluble carbodiimide.	Water	151-156	actin epsilon 1	Bos taurus	117-122
18341481-11	2008	These results support our model and indicate that StAR can readily bind to cholesterol with an apparent affinity that commensurates with monomeric cholesterol solubility in water.	Water	173-178	steroidogenic acute regulatory protein	Homo sapiens	50-54
8429910-4	1993	CHIP28 is a water channel in red blood cells and the kidney proximal tubule, but it is not expressed in the collecting tubule.	Water	12-17	aquaporin 1	Rattus norvegicus	0-6
8887277-2	1996	The mRNAs for HSP-27 and HSP-60 in renal papilla were two- to threefold greater in rats during water restriction than in those excreting a dilute urine, but levels of mRNA for HSP-70 were not reduced by water diuresis and Western analysis for HSP-70 protein showed no difference between water-loaded and water-restricted animals.	Water	95-100	heat shock protein family B (small) member 1	Rattus norvegicus	14-20
18459727-4	2008	Complex 1 forms a hydrogen-bonded one-dimensional metal-organic framework that stabilizes a helical water chain into its cavity, but when any of the amine hydrogen atoms of the Schiff base are replaced by methyl groups, as in L2 and L3, the water chain vanishes, showing explicitly the importance of the host-guest H-bonding interactions for the stabilization of a water cluster.	Water	241-246	immunoglobulin kappa variable 3-15	Homo sapiens	226-235
8784181-1	1996	The binding site of the dopamine D2 receptor, like that of other homologous G-protein-coupled receptors, is contained within a water-accessible crevice formed among its seven membrane-spanning segments.	Water	127-132	dopamine receptor D2	Homo sapiens	24-44
8425439-2	1993	This study was designed to examine whether EGF, PA, and PG affect the healing of acute gastric lesions induced by water immersion and restraint stress.	Water	114-119	epidermal growth factor like 1	Rattus norvegicus	43-46
8095031-0	1993	The role of thyrotropin-releasing hormone (TRH) in the pathogenesis of water-immersion stress in rats--inhibition of TRH release from the stomach by atropine, ranitidine or omeprazole.	Water	71-76	thyrotropin releasing hormone	Rattus norvegicus	12-41
18459727-4	2008	Complex 1 forms a hydrogen-bonded one-dimensional metal-organic framework that stabilizes a helical water chain into its cavity, but when any of the amine hydrogen atoms of the Schiff base are replaced by methyl groups, as in L2 and L3, the water chain vanishes, showing explicitly the importance of the host-guest H-bonding interactions for the stabilization of a water cluster.	Water	241-246	immunoglobulin kappa variable 3-15	Homo sapiens	226-235
8095031-0	1993	The role of thyrotropin-releasing hormone (TRH) in the pathogenesis of water-immersion stress in rats--inhibition of TRH release from the stomach by atropine, ranitidine or omeprazole.	Water	71-76	thyrotropin releasing hormone	Rattus norvegicus	43-46
8983941-1	1996	The purpose of this study was to determine whether a 9 kDa gamma D-crystallin fragment, on in vivo post-translational modifications, exists as isoforms in the water soluble protein fraction of human lenses.	Water	159-164	crystallin gamma D	Homo sapiens	59-77
8095031-1	1993	The role of thyrotropin-releasing hormone (TRH) in the development of gastric erosions and ulcers induced by water-immersion stress was studied.	Water	109-114	thyrotropin releasing hormone	Rattus norvegicus	12-41
18568791-1	2008	Beside their role in the control of water and electrolyte homeostasis, recent data clearly indicate that aldosterone and the mineralocorticoid receptor (MR) are involved in adipocyte biology.	Water	36-41	nuclear receptor subfamily 3 group C member 2	Homo sapiens	125-151
8095031-1	1993	The role of thyrotropin-releasing hormone (TRH) in the development of gastric erosions and ulcers induced by water-immersion stress was studied.	Water	109-114	thyrotropin releasing hormone	Rattus norvegicus	43-46
8095031-4	1993	Water-immersion stress induced a decrease in gastric wall ir-TRH concentrations and an increase in gastric juice ir-TRH concentrations with a decrease in gastric pH prior to ulcer formation.	Water	0-5	thyrotropin releasing hormone	Rattus norvegicus	61-64
8095031-4	1993	Water-immersion stress induced a decrease in gastric wall ir-TRH concentrations and an increase in gastric juice ir-TRH concentrations with a decrease in gastric pH prior to ulcer formation.	Water	0-5	thyrotropin releasing hormone	Rattus norvegicus	116-119
8636397-2	1996	To investigate a potential role for the AQP1 water channel in development, lung membranes from fetal and perinatal rats were analyzed by immunoblot.	Water	45-50	aquaporin 1	Rattus norvegicus	40-44
18568791-1	2008	Beside their role in the control of water and electrolyte homeostasis, recent data clearly indicate that aldosterone and the mineralocorticoid receptor (MR) are involved in adipocyte biology.	Water	36-41	nuclear receptor subfamily 3 group C member 2	Homo sapiens	153-155
8645165-1	1996	An eight-amino-acid synthetic peptide (IIe1-Phe2-Pro3-Pro4-Val5-Pro6-Gly7-Pro8) corresponding to the conserved proline-rich motif (PRM) of the intracellular domain of the prolactin receptor (PRL-R) was studied by one- and two-dimensional (1D and 2D) proton NMR spectroscopy in water and DMSO in order to characterize its conformational dynamics.	Water	277-282	prolactin receptor	Homo sapiens	171-189
18466396-4	2008	METHODS: APE-1 mRNA and protein expression were determined in H. pylori (CagA+) water-extract protein (HPWEP)-stimulated MKN-28 cells, gastric adenocarcinoma cell-line (AGS) cells, and human peripheral macrophages by real-time polymerase chain reaction and Western blot analysis.	Water	80-85	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	9-14
8743440-0	1996	Nitrate contamination of drinking water: relationship with HPRT variant frequency in lymphocyte DNA and urinary excretion of N-nitrosamines.	Water	34-39	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	59-63
8743440-10	1996	In conclusion, consumption of drinking water, especially well water, with high nitrate levels can imply a genotoxic risk for humans as indicated by increased HPRT variant frequencies and by endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite.	Water	39-44	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	158-162
8743440-10	1996	In conclusion, consumption of drinking water, especially well water, with high nitrate levels can imply a genotoxic risk for humans as indicated by increased HPRT variant frequencies and by endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite.	Water	62-67	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	158-162
8350273-18	1993	Finally, the subpressor dose of ET-3 amplifies free water excretion independent of systemic and renal haemodynamics, Na+ excretion, osmolal clearance, or circulating AVP levels.	Water	52-57	endothelin 3	Rattus norvegicus	32-36
8425536-2	1993	The effect of the paramagnetic high-spin Fe(III) ion in phenylalanine 4-monooxygenase (phenylalanine hydroxylase, EC 1.14.16.1) on the water proton longitudinal relaxation rate has been used to study the environment of the iron center.	Water	135-140	phenylalanine hydroxylase	Homo sapiens	56-85
8425536-2	1993	The effect of the paramagnetic high-spin Fe(III) ion in phenylalanine 4-monooxygenase (phenylalanine hydroxylase, EC 1.14.16.1) on the water proton longitudinal relaxation rate has been used to study the environment of the iron center.	Water	135-140	phenylalanine hydroxylase	Homo sapiens	87-112
8698840-6	1996	When pancreatic acini were preincubated with FGF-2 (1 nM) or vehicle (water) ADP-ribosylation of the alpha-subunit of Gi-type G-proteins by pertussis toxin was reduced in membranes prepared from FGF-2 pretreated acini as compared to control acini, suggesting functional interaction of FGF receptors with Gi-proteins.	Water	70-75	fibroblast growth factor 2	Rattus norvegicus	45-50
18537280-0	2008	Water properties in the super-salt-resistive gel probed by NMR and DSC.	Water	0-5	desmocollin 3	Homo sapiens	67-70
8698840-6	1996	When pancreatic acini were preincubated with FGF-2 (1 nM) or vehicle (water) ADP-ribosylation of the alpha-subunit of Gi-type G-proteins by pertussis toxin was reduced in membranes prepared from FGF-2 pretreated acini as compared to control acini, suggesting functional interaction of FGF receptors with Gi-proteins.	Water	70-75	fibroblast growth factor 2	Rattus norvegicus	195-200
8380331-12	1993	These structural changes at the Fea3-CuB binuclear site controlled by the redox levels of the metal centers may provide a functional role(s) for the cytochrome c oxidase-catalyzed reactions, such as the reduction of dioxygen to water and the vectorial proton pumping across the mitochondrial inner membrane.	Water	228-233	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	149-169
18537280-9	2008	On the other hand, the results of DSC measurements for P4VPh gel were less specific than those of T2 and comparable to those of common hydrogels such as PVA; with decreasing water content, the total amounts of free water and freezable bound water per polymer mass (g/g) decreased, while the amount of nonfreezing water per polymer also decreased.	Water	174-179	desmocollin 3	Homo sapiens	34-37
18454546-2	2008	The movement of the device (bob) is damped by the properties of the air-water surface adsorbed material.	Water	72-77	G protein-coupled receptor 15	Homo sapiens	28-31
7679139-2	1993	The effects of GH on individual body compartments--water, fat, protein and mineral--are achieved both by the action of GH and by a GH-induced hormone, insulin-like growth factor-I (IGF-I).	Water	51-56	insulin-like growth factor 1	Mus musculus	181-186
8741017-3	1996	Octanol-water partition coefficients (P(ow)) are correlated with these four surface-MEP descriptors: log P(ow) = c0 + c1B+F + c2B-F + c3B+R + c4B-R.	Water	8-13	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	142-147
18423784-8	2008	Water level data from a CW PRB at the Seneca Army Depot site, NY, are used for field demonstration.	Water	0-5	RB transcriptional corepressor 1	Homo sapiens	27-30
8691472-8	1996	Less potent but more water soluble compounds such as 13h (IC50 = 60 nM) and 13n (IC50 = 70 nM) are absorbed following oral dosing and achieve plasma levels significantly in excess of their IC50 for ACAT inhibition.	Water	21-26	sterol O-acyltransferase 1	Homo sapiens	198-202
21554653-3	1992	The water-soluble fraction of rat milk (infranatant, prepared by ultracentrifugation) and its methanol/acetic acid extract (milk-borne peptides) stimulated GH release from perifused pituitary glands obtained from 2-day-old rats.	Water	4-9	gonadotropin releasing hormone receptor	Rattus norvegicus	156-158
18296079-6	2008	The results taken together suggest that the expression and localization of AQP1 in mouse testis, epididymis and vas deferens are a stage-, tissue- and region-specific pattern and provide obvious clues that a possible relationship exists between the functional application of AQP1 for water reabsorption, and male reproduction and maturation.	Water	284-289	aquaporin 1	Mus musculus	75-79
10078291-8	1992	Standard methods agar (SMA) and trypticase soy agar (TSA) produced the next highest recovery for water and dialysate, respectively.	Water	97-102	survival of motor neuron 1, telomeric	Homo sapiens	23-26
8612802-4	1996	These results suggest that the outward pumping of both hydrophobic uncharged and water-soluble anionic compounds, including glutathione conjugates, is an inherent property of MRP, and offer sensitive methods for the functional diagnostics of this transport protein as well as for the rapid screening of drug-resistance modulating agents.	Water	81-86	ATP binding cassette subfamily C member 3	Homo sapiens	175-178
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Water	173-178	solute carrier family 9 member A3	Rattus norvegicus	70-75
8731356-6	1996	The AT1 receptor antagonist DUP-753 (50 nmol/microliters) injected into the LV reduced water intake induced by ANG II (10 nmol/microliters) from 9.2 +/- 1.4 to 0.4 +/- 0.1 ml/h (N = 8), and water intake induced by carbachol (2 nmol/microliters) from 9.8 +/- 1.4 ml/h to 3.7 +/- 0.8 ml/h (N = 8).	Water	87-92	angiotensin II receptor, type 1a	Rattus norvegicus	4-7
1396669-5	1992	Our results support the notion that there is only one lysosomal sialidase, which degrades both the water-soluble and the membrane-bound sialyl glycoconjugates.	Water	99-104	neuraminidase 1	Homo sapiens	54-73
18068959-0	2008	Phosvitin-calcium aggregation and organization at the air-water interface.	Water	58-63	casein kinase 2 beta	Homo sapiens	0-9
1422835-4	1992	injections of amastatin, an aminopeptidase A inhibitor, potentiated water intake induced by subcutaneous injections of hypertonic saline.	Water	68-73	glutamyl aminopeptidase	Homo sapiens	28-44
8731356-6	1996	The AT1 receptor antagonist DUP-753 (50 nmol/microliters) injected into the LV reduced water intake induced by ANG II (10 nmol/microliters) from 9.2 +/- 1.4 to 0.4 +/- 0.1 ml/h (N = 8), and water intake induced by carbachol (2 nmol/microliters) from 9.8 +/- 1.4 ml/h to 3.7 +/- 0.8 ml/h (N = 8).	Water	190-195	angiotensin II receptor, type 1a	Rattus norvegicus	4-7
18068959-6	2008	We demonstrated that phosvitin is able to anchor at air-water interfaces in spite of its numerous negative charges.	Water	56-61	casein kinase 2 beta	Homo sapiens	21-30
8543796-10	1996	Moreover, regional lymph node cells obtained from alpha-MSH-treated mice 5 days after resensitization failed to produce IL-2 in response to trinitrobenzosulfonic acid, the water-soluble analogue of TNCB, whereas lymph node cells from TNCB-sensitized, not alpha-MSH-treated, mice as well as from mice treated with alpha-MSH before challenge readily exhibited trinitrobenzosulfonic acid-specific IL-2 production in this assay.	Water	172-177	pro-opiomelanocortin-alpha	Mus musculus	50-59
1446302-3	1992	The chemical shifts of the C-6 resonances are also sensitive to hydrogen-bonding interactions, as shown by the spectral changes on loss of water from the structures.	Water	139-144	complement C6	Homo sapiens	27-30
18281604-6	2008	Potentiation of VASP Ser(157) phosphorylation by either phosphatase 2B inhibition with cyclosporin or protein kinase A activation with forskolin prolonged, rather than inhibited, the increased permeability caused by H(2)O(2).	Water	216-221	vasodilator stimulated phosphoprotein	Homo sapiens	16-20
1393608-5	1992	In the first experiment, ADX animals were initially treated systematically with CORT (20 micrograms/ml in their drinking water).	Water	121-126	cortistatin	Rattus norvegicus	80-84
21619230-10	1996	Good agreement was obtained between a 45-min SPME and methylene chloride extraction for the determination of PAH concentrations in creosote-contaminated water, demonstrating that SPME is a useful technique for the rapid determination of hydrocarbons in complex water matrices.	Water	153-158	phenylalanine hydroxylase	Homo sapiens	109-112
9010585-1	1996	CYP2B1 and 2E1 oxidized toluene, aniline and monochlorobenzene (MCB) to water-soluble metabolites and to products covalently binding to microsomal proteins from male Wistar rats at high efficiency.	Water	72-77	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	0-14
8993847-7	1996	Circulating AngII acts on AT1 receptors in the subfornical organ and organum vasculosum of the lamina terminalis (OVLT) to stimulate neurons that may have a role in initiating water drinking.	Water	176-181	angiotensin II receptor, type 1a	Rattus norvegicus	26-29
18306172-3	2008	In addition, the spectra show that a substantial amount of water molecules is trapped between the glutaric acid and the hydroxyapatite surface, indicating that water molecules may play a prominent role in the noncovalent interaction of the glutaric acid and the HAp surface.	Water	59-64	reticulon 3	Homo sapiens	262-265
1512262-7	1992	In the R2-state, His-97 beta 2 simply rotates away from threonines 38 alpha 1 and 41 alpha 1, breaking contact with these residues and allowing water access to the center of the alpha 1 beta 2 interface.	Water	144-149	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	24-30
8631196-3	1996	However, the vitamin E treatment had no effect not only on a decrease in reduced glutathione content, but also on increases in water and xylitol contents, which are known to be induced via aldose reductase, in the D-xylose-treated lenses.	Water	127-132	aldo-keto reductase family 1 member B1	Rattus norvegicus	189-205
18306172-3	2008	In addition, the spectra show that a substantial amount of water molecules is trapped between the glutaric acid and the hydroxyapatite surface, indicating that water molecules may play a prominent role in the noncovalent interaction of the glutaric acid and the HAp surface.	Water	160-165	reticulon 3	Homo sapiens	262-265
18302414-2	2008	This method employs molecular iodine to mediate the cyclization from the 5"-Omicron-hydroxyl group of the sugar ring and C-6 at the position of the nitrogen base in ammonia water under mild conditions without any other aprotic organic solvent.	Water	173-178	complement C6	Homo sapiens	121-124
8907494-6	1996	In contrast, the C-terminal extension of betaB2-crystallin in water has a structural preference towards turn-like structures, creating a hydrophobic region involving G198, F200 and P202.	Water	62-67	crystallin beta B2	Bos taurus	41-58
1418688-2	1992	When cholesterol and linoleic acid were used as the substrates, PEG-modified CEH synthesized cholesterol linoleate only in water-immiscible organic solvents.	Water	123-128	carboxylesterase 1	Homo sapiens	77-80
1426981-5	1992	N-terminally extended analogs of AVP: Ala-AVP (VI); Ser-Ala-AVP (VII) and Thr-Ser-Ala-AVP (VIII) stimulated osmotic water flux to the same extent in concentration 200 times higher as that of AVP.	Water	116-121	cytochrome c oxidase subunit 8A	Homo sapiens	91-95
18052225-0	2008	The effect of surface ions on water adsorption to mica.	Water	30-35	MHC class I polypeptide-related sequence A	Homo sapiens	50-54
8640448-0	1996	MTS interferon assay: a simplified cellular dehydrogenase assay for interferon activity using a water-soluble tetrazolium salt.	Water	96-101	MLRL	Homo sapiens	0-3
8640448-1	1996	MTS, a tetrazolium dye, is reduced by hydrogenases in living cells to a water-soluble formazan.	Water	72-77	MLRL	Homo sapiens	0-3
18052225-1	2008	We have measured the adsorption isotherms of water on a single surface of freshly cleaved mica with K+ on the surface, and on mica where the K+ has been exchanged for H+.	Water	45-50	MHC class I polypeptide-related sequence A	Homo sapiens	90-94
17928628-7	2008	Differentially regulated genes included several encoding proteins involved in spermatozoal maturation, water and ion channels, and beta-defensins: CRISP1, SPINLW1, FAM12B, and DEFB129 were upregulated, whereas CFTR, AQP5, KCNK4, KCNK17, SLC6A20, SLC13A3, DEFB126, and DEFB106A were downregulated.	Water	103-108	epididymal protein 3B	Homo sapiens	164-170
18966460-0	1996	Study of chemical modifiers for direct determination of silver in sea water by ETA-AAS with deuterium background correction.	Water	70-75	endothelin receptor type A	Homo sapiens	79-82
8608666-11	1995	We conclude that simultaneous measurements of plasma BNP and ANP further discriminate salt-water and hemodynamic abnormalities in dialysis patients.	Water	91-96	natriuretic peptide B	Homo sapiens	53-56
18086951-3	2008	In the current study we determined the effects of overexpression of AT(2)R in the RVLM on sodium and water excretion and on blood pressure in conscious rats.	Water	101-106	angiotensin II receptor, type 2	Rattus norvegicus	68-74
7561150-4	1995	Aggregation of surface antigen receptors (TCR-CD3 complex and CD28 on T cells) with specific antibodies produced extensive ATP and Mg(2+)-dependent hydrolysis of the membrane inositol phospholipids as measured by release of water soluble inositol phosphates.	Water	224-229	CD28 molecule	Homo sapiens	62-66
17671517-7	2008	In HSE generated under normal culture conditions (93% relative humidity (RH)), the water level and PCA content appeared to be much lower than in the native counterpart.	Water	83-88	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	3-6
7576100-1	1995	In this study, we found that rat nasal coumarin-7-hydroxylase (COH) activity was two orders of magnitude higher than rat hepatic COH activity and could be induced by adding coumarin to the rats" drinking water.	Water	204-209	cytochrome P450, family 2, subfamily a, polypeptide 3	Rattus norvegicus	39-61
7576100-1	1995	In this study, we found that rat nasal coumarin-7-hydroxylase (COH) activity was two orders of magnitude higher than rat hepatic COH activity and could be induced by adding coumarin to the rats" drinking water.	Water	204-209	cytochrome P450, family 2, subfamily a, polypeptide 3	Rattus norvegicus	63-66
17671517-8	2008	To increase the water and PCA levels in HSE, a culture method was established in which HSE was reconstructed under reduced RH.	Water	16-21	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	40-43
7576100-1	1995	In this study, we found that rat nasal coumarin-7-hydroxylase (COH) activity was two orders of magnitude higher than rat hepatic COH activity and could be induced by adding coumarin to the rats" drinking water.	Water	204-209	cytochrome P450, family 2, subfamily a, polypeptide 3	Rattus norvegicus	129-132
17671517-8	2008	To increase the water and PCA levels in HSE, a culture method was established in which HSE was reconstructed under reduced RH.	Water	16-21	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	87-90
17671517-11	2008	This clearly shows that the stratum corneum water level in HSE is regulated by other, still unknown, factors, in addition to NMF.	Water	44-49	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	59-62
8588813-4	1995	The expression for the reaction rate (for substrates AA1 and AA2) is shown to be v = k[Boc-AA1-OTfs][H-AA2-NH2]0.5 for both water and DMF, i.e., the reaction is not a simple second-order reaction.	Water	124-129	AA1	Homo sapiens	53-56
18190999-2	2008	Attraction in Aplysia involves the long-distance water-borne protein pheromones attractin, enticin, temptin and seductin, which are released from the albumen gland during egg laying.	Water	49-54	attractin	Aplysia californica	80-89
8588813-4	1995	The expression for the reaction rate (for substrates AA1 and AA2) is shown to be v = k[Boc-AA1-OTfs][H-AA2-NH2]0.5 for both water and DMF, i.e., the reaction is not a simple second-order reaction.	Water	124-129	AA1	Homo sapiens	91-94
8527674-1	1995	Immobilized protein solute, approximately 20 wt %, alters the longitudinal and transverse nuclear magnetic relaxation rates 1/T1 and 1/T2 of solvent water protons in a manner that makes their values indistinguishable from those of a typical human tissue.	Water	149-154	interleukin 1 receptor like 1	Homo sapiens	126-134
8527674-8	1995	The sites that dominate relaxation-and produce contrast in magnetic resonance imaging (MRI), which derives from 1/T1 and 1/T2 of tissue water protons-have tau M approximately 10(-6)s. These, which involve four hydrogen bonds, occupy &lt; or = 1% of the protein-water interface.	Water	136-141	interleukin 1 receptor like 1	Homo sapiens	114-122
18221514-7	2008	The divergence in the dynamic properties of eEF1A1 and eEF1A2 is caused by interactions of amino acid residues that differ between the two variants with neighboring residues and water environment.	Water	178-183	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	44-50
7649491-2	1995	In the presence of a trace of water, the main products were the spirodimer (PSD) and spirotrimer (PST).	Water	30-35	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	98-101
18086569-4	2008	Moreover, 12R-LOX-deficient mice exhibit severe phenotypic water barrier dysfunctions.	Water	59-64	arachidonate 12-lipoxygenase, 12R type	Mus musculus	10-17
18076200-3	2008	The initiator grafting on the mica substrate was confirmed by time-of-flight secondary ion mass spectrometry (TOF-SIMS), while the change in the water contact angle of the OH-activated mica surface was used to follow the change in surface coverage of the initiator on the surface.	Water	145-150	MHC class I polypeptide-related sequence A	Homo sapiens	185-189
7476082-2	1995	1/T1 and 1/T2 of solvent water protons are increased dramatically by magnetic interactions in the "outer sphere" environment of the nanoparticles; subsequent diffusive mixing distributes this relaxation throughout the solvent.	Water	25-30	interleukin 1 receptor like 1	Homo sapiens	2-10
7543677-0	1995	Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells.	Water	78-83	aquaporin 2	Sus scrofa	66-77
18052254-1	2008	Fully coupled nitric oxide synthase (NOS) catalyzes formation of nitric oxide (NO), l-citrulline, NADP+, and water from l-arginine, NADPH, and oxygen.	Water	109-114	nitric oxide synthase 1	Homo sapiens	14-35
7543677-6	1995	The basal water permeability of AQP1-transfected cells was 2-fold greater than that of nontransfected cells, whereas the permeability of AQP2-transfected cells increased significantly only after vasopressin treatment.	Water	10-15	aquaporin-1	Sus scrofa	32-36
17967413-3	2008	Our laboratory using Langmuir monolayers of apolipoproteins has previously shown that upon lateral compression at the air/water and phospholipid/water interfaces, there is an important movement of the C-terminal segment of apolipoprotein CI towards the air, considered the hydrophobic region of the monolayer and the acyl-chain region of the interface when phospholipids are used.	Water	122-127	apolipoprotein C1	Homo sapiens	223-240
7542207-1	1995	The histidine at position 1106 of the C4B isotype of human complement is involved in catalyzing the covalent binding of the thioester to glycerol and water.	Water	150-155	complement C4B (Chido blood group)	Homo sapiens	38-41
17967413-3	2008	Our laboratory using Langmuir monolayers of apolipoproteins has previously shown that upon lateral compression at the air/water and phospholipid/water interfaces, there is an important movement of the C-terminal segment of apolipoprotein CI towards the air, considered the hydrophobic region of the monolayer and the acyl-chain region of the interface when phospholipids are used.	Water	145-150	apolipoprotein C1	Homo sapiens	223-240
18290321-4	2008	H(+)-ions exported from the intracellular space into the interstitial compartment titrate extracellular bicarbonate to CO2 and H2O with the aid of the ectoenzyme carbonic anhydrase IX, which is activated at low pH.	Water	127-130	carbonic anhydrase 9	Homo sapiens	162-183
8573880-3	1995	RFGD using H2O vapor was used to functionalize the membrane surface, reacted with 1",1 carbonyldiimidazole and covalently bound with oligopeptides (RGDS, RGES).	Water	11-14	ral guanine nucleotide dissociation stimulator	Homo sapiens	148-152
7552237-1	1995	Copoly (dl-lactic/glycolic acid) microparticles for sustained release of a water-soluble drug (Thyrotropin releasing hormone: TRH) were prepared by a spray drying method.	Water	75-80	thyrotropin releasing hormone	Homo sapiens	126-129
17611738-8	2008	No significant decrease of the EC(50) values was found when HGF or HPF, respectively, was exposed to HEMA or BisGMA in addition with H(2)O(2) up to the concentration of 0.1 mmol/l, as compared to those EC(50) values of each compound without H(2)O(2) addition.	Water	133-138	hepatocyte growth factor	Homo sapiens	60-63
7611515-6	1995	These findings suggest that water intake produced by microinjection of ANG II into the OCPLT is mediated by AT1 receptors uniquely and that, in contrast to other regions of the brain, these receptors do not induce salt intake when stimulated by ANG II.	Water	28-33	angiotensin II receptor type 1	Homo sapiens	108-111
7670125-3	1995	Treatment with TRH resulted in significantly decreased hypothalamic oxytocin content in both euhydrated (i.e. given tap water ad libitum) and salt-loaded rats.	Water	120-125	thyrotropin releasing hormone	Rattus norvegicus	15-18
17766341-8	2008	A network of hydrogen-bonded water molecules leading from the bulk water to the zinc-coordinated ligands in the ABP1 binding site was formed in all simulations.	Water	29-34	amine oxidase copper containing 1	Homo sapiens	112-116
7794949-0	1995	Calcium ions and interactions of pulmonary surfactant proteins SP-B and SP-C with phospholipids in spread monolayers at the air/water interface.	Water	128-133	surfactant protein B	Homo sapiens	63-67
7756271-3	1995	The m-poly(ethylene glycol)-porin (m-PEG-SC-Porin 50) conjugate, containing one poly(ethylene glycol) chain, was water soluble.	Water	113-118	voltage dependent anion channel 1	Homo sapiens	28-33
7756271-3	1995	The m-poly(ethylene glycol)-porin (m-PEG-SC-Porin 50) conjugate, containing one poly(ethylene glycol) chain, was water soluble.	Water	113-118	voltage dependent anion channel 1	Homo sapiens	44-49
17766341-8	2008	A network of hydrogen-bonded water molecules leading from the bulk water to the zinc-coordinated ligands in the ABP1 binding site was formed in all simulations.	Water	67-72	amine oxidase copper containing 1	Homo sapiens	112-116
7728761-8	1995	The data presented suggest that PP-1/2A may, at least in vitro, be targeted by water-soluble active compounds present in cigarette smoke.	Water	79-84	protein phosphatase 1 catalytic subunit gamma	Mus musculus	32-39
17766341-10	2008	These results suggest that the hydrogen-bonded water molecules may assist in protonation and deprotonation of auxin molecules and their egress from the ABP1 binding site.	Water	47-52	amine oxidase copper containing 1	Homo sapiens	152-156
18776435-4	2008	The heat capacity change, Delta C(p), accompanying the duplex formation, obtained through DSC, has also been reported and has been used to furnish thermodynamic parameters at 37 degrees C. Furthermore, it was observed that relative to the formation of unmodified duplex, the formation of LNA-modified duplexes was accompanied by a higher uptake of counterions and a lower uptake of water molecules.	Water	382-387	desmocollin 3	Homo sapiens	90-93
7543847-2	1995	In this study we examined the effect of microtubule disruption by colchicine on 1) the subcellular organization of the apical endocytic apparatus, 2) apical endocytosis, and 3) subcellular distribution of gp330 and Aquaporin-1 water channels in renal proximal tubule cells.	Water	227-232	aquaporin 1	Rattus norvegicus	215-226
7543847-14	1995	Also Aquaporin-1 water channels, which are normally almost exclusively present in the plasma membranes, are redistributed to small vesicles in addition to the plasma membrane localization after colchicine treatment.	Water	17-22	aquaporin 1	Rattus norvegicus	5-16
7620095-2	1995	In Sprague-Dawley rats, 3 days of water diuresis reduced inner medullary aldose reductase mRNA abundance 6.5-fold compared with untreated rats, whereas sorbitol dehydrogenase and taurine cotransporter mRNA were unchanged.	Water	34-39	aldo-keto reductase family 1 member B1	Rattus norvegicus	73-89
7620095-5	1995	Finally, in Brattleboro rats, urine osmolality and levels of aldose reductase and taurine cotransporter mRNA increased in response to 1 day of water deprivation, whereas sorbitol dehydrogenase mRNA was unchanged.	Water	143-148	aldo-keto reductase family 1 member B1	Rattus norvegicus	61-77
7536742-0	1995	Water channel properties of major intrinsic protein of lens.	Water	0-5	major intrinsic protein of lens fiber	Bos taurus	28-51
7536742-1	1995	The functions of major intrinsic protein (MIP) of lens are still unresolved; however the sequence homology with channel-forming integral membrane protein (CHIP) and other Aquaporins suggests that MIP is a water channel.	Water	205-210	major intrinsic protein of lens fiber	Bos taurus	17-40
7536742-1	1995	The functions of major intrinsic protein (MIP) of lens are still unresolved; however the sequence homology with channel-forming integral membrane protein (CHIP) and other Aquaporins suggests that MIP is a water channel.	Water	205-210	major intrinsic protein of lens fiber	Bos taurus	42-45
7536742-1	1995	The functions of major intrinsic protein (MIP) of lens are still unresolved; however the sequence homology with channel-forming integral membrane protein (CHIP) and other Aquaporins suggests that MIP is a water channel.	Water	205-210	major intrinsic protein of lens fiber	Bos taurus	196-199
7536742-4	1995	When compared with water-injected control oocytes, the coefficient of osmotic water permeability (Pf) of MIP oocytes was increased 4-5-fold with a low Arrhenius activation energy, while the Pf of CHIP oocytes increased &gt; 30-fold.	Water	19-24	major intrinsic protein of lens fiber	Bos taurus	105-108
7536742-4	1995	When compared with water-injected control oocytes, the coefficient of osmotic water permeability (Pf) of MIP oocytes was increased 4-5-fold with a low Arrhenius activation energy, while the Pf of CHIP oocytes increased &gt; 30-fold.	Water	78-83	major intrinsic protein of lens fiber	Bos taurus	105-108
7536742-8	1995	Thus oocytes expressing MIP failed to exhibit ion channel activity and consistently exhibited water transport by a facilitated pathway that was qualitatively similar to the Aquaporins but of lesser magnitude.	Water	94-99	major intrinsic protein of lens fiber	Bos taurus	24-27
7895693-5	1995	These data demonstrate cell-specific regulation of oxytocin receptor expression in macula densa and proximal tubule cells, and suggest a important role for these receptors in mediating estrogen-induced alterations in renal fluid dynamics by possibly affecting glomerular filtration and water and solute reabsorption during high estrogen states.	Water	286-291	oxytocin receptor	Rattus norvegicus	51-68
7890723-7	1995	By comparing lipid exchange, lipid binding, and immunological properties of the water-soluble lipid exchange proteins it can be shown that the 13-kDa (peak 3) protein is related to the 100-120 kDa (peak 1) protein; the properties of these two proteins are different from those of the peak 2 lipid exchange protein of apparent molecular mass of 22 kDa.	Water	80-85	pseudopodium-enriched atypical kinase 1	Oryctolagus cuniculus	198-204
21153199-6	1995	Similarly, levels of mRNA encoding catalase (2.1 kb), an enzyme responsible for detoxification of peroxides to water, were significantly higher in functional versus regressed CL.	Water	111-116	catalase	Bos taurus	35-43
7696561-5	1995	The gel strength, as measured by the magnitude of the storage modulus at comparable mucin concentrations, is greatest for distilled water, intermediate for 0.1M NaCl, and lowest for 6M GdnHCl.	Water	132-137	LOC100508689	Homo sapiens	84-89
7696561-6	1995	In distilled water, high molecular weight mucin undergoes a sol-gel transition at approximately 12 mg/mL, and shows evidence of a plateau modulus at higher concentrations.	Water	13-18	LOC100508689	Homo sapiens	42-47
7696561-11	1995	However, low molecular weight mucin in distilled water shows a strain-dependent increase in elasticity at low frequency indicative of weak intermolecular associations.	Water	49-54	LOC100508689	Homo sapiens	30-35
7539499-1	1995	A water channel, the frog aquaporin-CHIP (FA-CHIP) was recently cloned from Rana esculenta urinary bladder.	Water	2-7	aquaporin 1	Rattus norvegicus	26-40
8587436-11	1995	We therefore suggest that the upregulation of medullary ETB in cirrhotic rats is involved int he regulation of water excretion in rats with CCl4-induced cirrhosis.	Water	111-116	endothelin receptor type B	Rattus norvegicus	56-59
8577072-6	1995	The EGF signal was transduced through a pathway including protein kinase C. GLUT1 is reported to work as a water transporter, and so EGF can be considered as one of the possible agent which stimulate water transport activity through the corneal endothelial cells.	Water	107-112	solute carrier family 2 member 1	Bos taurus	76-81
7770452-2	1995	Voltage gating is seen as a perturbation of the electrostatic screening inside the porin pore where, by the influence of the potential gradient, water and counter-ion distribution can be slightly displaced from their equilibrium distribution.	Water	145-150	voltage dependent anion channel 1	Homo sapiens	83-88
10057294-0	1994	Water adsorption on perfect CaF2 (111) studied with He scattering: Experimental evidence for ordering of nanoclusters.	Water	0-5	CCR4-NOT transcription complex subunit 8	Homo sapiens	28-32
7756988-0	1994	The structures of RNase A complexed with 3"-CMP and d(CpA): active site conformation and conserved water molecules.	Water	99-104	ribonuclease A family member 1, pancreatic	Homo sapiens	18-25
7981242-1	1994	In many cell types extracellular ATP (ATPe) has been shown to cause reversible plasma membrane permeabilization to low molecular weight (&lt; 900 Da) water-soluble compounds.	Water	150-155	ATP synthase F1 subunit epsilon	Homo sapiens	38-42
7962346-8	1994	These facts support the proposal that adrenomedullary BNP along with ANP may play some role in water and electrolyte homeostasis or act in a paracrine manner to regulate adrenocortical functions.	Water	95-100	natriuretic peptide B	Homo sapiens	54-57
8078898-9	1994	1H NMR data indicate that each of the single-mutant heme-Hx complexes is predominantly low-spin, perhaps owing to coordination of the heme iron by the Thr side-chain oxygen or water oxygen coordinating to the iron.	Water	176-181	hemopexin	Homo sapiens	57-59
8054318-2	1994	Regional cerebral blood flow (rCBF) patterns demonstrated by 15O water PET during saccadic task performance were tested in 13 normal volunteers and 20 ICD-9 schizo phrenics (10 unmedicated and 10 medicated).	Water	65-70	CCAAT/enhancer binding protein zeta	Rattus norvegicus	30-34
8185624-4	1994	The percentages of Thy 1.2-(pan T cells), L3T4-(helper T cells) and Lyt2-(cytotoxic T cells) positive cell population were significantly increased in the mice orally administered hot water soluble fraction from wild Panax ginseng as compared to control by 31.2, 17.9 and 30.1 percent, respectively.	Water	183-188	CD8 antigen, alpha chain	Mus musculus	68-72
8017937-1	1994	Enzyme assays for 4-methylumbelliferyl-beta-D-galactopyranosidase and 4-methylumbelliferyl-beta-D-glucuronidase activities were used for rapid detection (25 min) of fecal water pollution and to determine the impact of sewage discharge in coastal waters.	Water	171-176	glucuronidase beta	Homo sapiens	91-111
7925697-1	1994	The presence of a 9-kDa gamma D-crystallin fragment among water-soluble (WS) and water-insoluble (WI) proteins of human lenses was investigated using individual site specific antibodies to the N- and C-terminal regions of the molecule.	Water	58-63	crystallin gamma D	Homo sapiens	24-42
7925697-1	1994	The presence of a 9-kDa gamma D-crystallin fragment among water-soluble (WS) and water-insoluble (WI) proteins of human lenses was investigated using individual site specific antibodies to the N- and C-terminal regions of the molecule.	Water	81-86	crystallin gamma D	Homo sapiens	24-42
8203869-5	1994	In the case of encapsulated cytochrome c, the more water-soluble S-oxide was obtained with much higher selectivity over the less water-soluble sulfone (S-oxide/sulfone = 7.1) as compared to what was obtained in the aqueous/organic medium (S-oxide/sulfone = 2.3).	Water	51-56	LOC104968582	Bos taurus	28-40
8203869-5	1994	In the case of encapsulated cytochrome c, the more water-soluble S-oxide was obtained with much higher selectivity over the less water-soluble sulfone (S-oxide/sulfone = 7.1) as compared to what was obtained in the aqueous/organic medium (S-oxide/sulfone = 2.3).	Water	129-134	LOC104968582	Bos taurus	28-40
8161212-5	1994	Analysis of water soluble metabolites of [methyl-14C]choline phosphate revealed the accumulation of CDP-choline precursor in samples derived from ethanol-fed rats.	Water	12-17	cut-like homeobox 1	Rattus norvegicus	100-103
7518704-0	1994	Myelin basic protein interaction with zinc and phosphate: fluorescence studies on the water-soluble form of the protein.	Water	86-91	myelin basic protein	Homo sapiens	0-20
8038387-2	1994	Spread binary monolayers of surfactant-associated proteins SP-B and SP-C were formed at the air-water interface.	Water	96-101	surfactant protein B	Homo sapiens	59-63
7510408-1	1994	Parallel measurements of the thermodynamics (free-energy, enthalpy, entropy and heat-capacity changes) of ligand binding to FK506 binding protein (FKBP-12) in H2O and D2O have been performed in an effort to probe the energetic contributions of single protein-ligand hydrogen bonds formed in the binding reactions.	Water	159-162	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	147-154
7510408-2	1994	Changing tyrosine-82 to phenylalanine in FKBP-12 abolishes protein-ligand hydrogen bond interactions in the FKBP-12 complexes with tacrolimus or rapamycin and leads to a large apparent enthalpic stabilization of binding in both H2O and D2O.	Water	228-231	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	41-48
7510408-3	1994	High-resolution crystallographic analysis reveals that two water molecules bound to the tyrosine-82 hydroxyl group in unliganded FKBP-12 are displaced upon formation of the protein-ligand complexes.	Water	59-64	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	129-136
7510408-5	1994	Despite the less favorable enthalpy change, the entropic advantage of displacing two water molecules upon binding leads to a slightly more favorable free-energy change of binding in the reactions with wild-type FKBP-12.	Water	85-90	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	211-218
8313508-7	1994	Corn oil-gavaged rats had 54% lower serum growth hormone (GH) levels, and replacement of GH into corn oil-gavaged rats by osmotic minipump infusion increased in situ MNCL cell proliferation to rates observed in water-gavaged animals.	Water	211-216	gonadotropin releasing hormone receptor	Rattus norvegicus	89-91
1504511-0	1992	Carbon filtration of EDB-contaminated well water: a one-year study.	Water	43-48	vesicle associated membrane protein 8	Homo sapiens	21-24
1583405-2	1992	Injection of distilled water (4 ml within 5 seconds) into the carotid arteries of rats resulted in intravascular hemolysis leading to hemoglobinemia, hemoglobinuria, reduction in inulin clearance, and elevation of urine N-acetyl-beta-D-glucosaminidase (NAG) excretion.	Water	23-28	O-GlcNAcase	Rattus norvegicus	253-256
1407656-2	1992	When rats were orchidectomized (castrated) and stressed by restraint and immersion in water for 15 min/day for 30 days, significant loss of hippocampal CA3 and CA4 neurons was observed.	Water	86-91	carbonic anhydrase 4	Rattus norvegicus	160-163
1515929-6	1992	These results demonstrate that centrally administered ANG II and ANG III increase both water intake and blood pressure via the AT1 receptor subtype.	Water	87-92	angiotensin II receptor, type 1a	Rattus norvegicus	127-130
1534419-1	1992	Synthetic humic acid, well water humic acid and commercial humic acid (Aldrich) all have the ability to inhibit human plasmin activity.	Water	27-32	plasminogen	Homo sapiens	118-125
1735699-2	1992	The in vivo tumor/plasma partition coefficient (PTP) of sensitizers increased with increase in the octanol/water partition coefficient (Pow) up to approximately 0.3 and was almost unity (maximum) for sensitizers with their Pow values larger than approximately 0.3.	Water	107-112	protein tyrosine phosphatase receptor type U	Homo sapiens	48-51
1806655-10	1991	A hypothesis accounting for this difference is proposed, in which the association rate of EGF to the cell surface receptor is considered to be limited by the diffusion in the unstirred water layer in the interstitial space of the intact liver such as the perfused liver.	Water	185-190	epidermal growth factor like 1	Rattus norvegicus	90-93
1951766-4	1991	Male Sprague-Dawley strain rats were dehydrated by exposure to a 40 degree C environment for 2-4 h or by water deprivation for 44 h. Water deprivation but not heat exposure significantly increased plasma renin activity.	Water	133-138	renin	Rattus norvegicus	204-209
1941632-17	1991	As the AT1 receptors are responsible for AII-induced vasoconstriction, aldosterone secretion, and water drinking, our study indicates that DuP 532 is a potent, orally active, selective, and noncompetitive AT1 receptor antagonist and antihypertensive agent.	Water	98-103	angiotensin II receptor, type 1a	Rattus norvegicus	7-10
1802684-5	1991	On the other hand, the low dose of ET-3 significantly increased the GFR, urine volume and free-water clearance with no change in the perfusion pressure or synthesis of PGs.	Water	95-100	endothelin 3	Rattus norvegicus	35-39
1802684-6	1991	These findings suggest that a low dose of ET-3 can increase the glomerular capillary ultrafiltration coefficient and that ET-3 exerts an influence on sodium and water handing in the rat PK.	Water	161-166	endothelin 3	Rattus norvegicus	122-126
2056181-4	1991	This paper reports the T1 and T2 water proton relaxation times of the different skin layers, in vivo, which are magnetic resonance parameters extracted from the images.	Water	33-38	interleukin 1 receptor like 1	Homo sapiens	23-32
1904725-3	1991	The intracisternal injection of bFGF dose-dependently (0.1-1.0 microgram(s)/rat) inhibited the severity of gastric ulcers induced by water-immersion restraint stress or central thyrotropin-releasing hormone.	Water	133-138	fibroblast growth factor 2	Rattus norvegicus	32-36
1884112-3	1991	However in water-deprived (i.e. renin-dependent) Brattleboro rats, DuP 753 caused marked hypotension and regional vasodilatations.	Water	11-16	renin	Rattus norvegicus	32-37
1831462-0	1991	Kinetics of ATP release and Pi binding during the ATPase cycle of lethocerus flight muscle fibres, using phosphate-water oxygen exchange.	Water	115-120	dynein axonemal heavy chain 8	Homo sapiens	50-56
1650376-0	1991	Derangement of microtubule arrays in interphase and mitotic PtK2 cells treated with deuterium oxide (heavy water).	Water	107-112	protein tyrosine kinase 2	Homo sapiens	60-64
8162991-2	1994	Two of these, SP-A and SP-D, are large and water-soluble, while SP-B and SP-C are small and very hydrophobic.	Water	43-48	surfactant protein A1	Homo sapiens	14-18
18181245-5	2008	With increasing methanol, at pH near neutrality, apo-CRBP exhibits a progressively more compact conformation, resulting in reduced H/D exchange with respect to the native protein in water.	Water	182-187	retinol binding protein 1	Homo sapiens	53-57
7508187-1	1994	The cloning and expression of an apical membrane water channel from rat kidney collecting duct (WCH-CD) homologous to a 28-kDa integral membrane protein (CHIP28) was reported recently (K. Fushimi, S. Uchida, Y. Hara, Y. Hirata, F. Marumo, and S. Sasaki.	Water	49-54	aquaporin 1	Rattus norvegicus	154-160
8168228-2	1994	The solubility experiments show that, there are two major forms of AChE i.e. water-soluble and membrane-bound AChE (MBAChE).	Water	77-82	acetylcholinesterase (Cartwright blood group)	Gallus gallus	67-71
18957751-2	2008	The results revealed that urban, rural and dormitory grey water production rate and concentration of TS, BOD(5), COD and pathogens varied between 18-66 L cap(-1)d(-1), 848-1,919, 200-1,056, and 560-2,568 mg L(-1) and 6.9E2-2.7E5 CFU mL(-1), respectively.	Water	58-63	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	154-160
8149234-3	1993	The brain renin-angiotensin system plays an important role in the regulation of water and electrolyte balance and neuroendocrine function.	Water	80-85	renin	Rattus norvegicus	10-15
18036379-1	2007	A dodecylsulfate-doped polypyrrole (PPy-DS) film was prepared by electrochemical fiber coating (EFC) technique and applied as a new fiber for headspace solid-phase microextraction (HS-SPME) of phenolic compounds from water samples.	Water	217-222	pancreatic polypeptide	Homo sapiens	36-39
7505572-1	1993	Two kidney water channels have been identified: CHIP28 in proximal tubule and thin descending limb, and WCH-CD in collecting duct apical membrane.	Water	11-16	aquaporin 1	Rattus norvegicus	48-54
8230430-7	1993	The availability of cells producing water-soluble oligomers of HIV-1 Env should facilitate studies of envelope glycoprotein structure and function.	Water	36-41	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	69-72
8218256-1	1993	The integral membrane protein CHIP28 is an important water channel in erythrocytes and kidney tubule epithelia and is a member of a family of channel/pore proteins including the lens protein MIP26.	Water	53-58	major intrinsic protein of lens fiber	Bos taurus	191-196
18053222-8	2007	RESULTS: A consistent negative effect for APE1 was observed across water, toenail and urinary arsenic models.	Water	67-72	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	42-46
8218214-10	1993	Saturation of the water resonance caused a large negative NOE at H1 (eta = -0.55) consistent with our earlier study which indicated that there was no direct dipolar interaction between H1 and free H2O.	Water	18-23	endothelin receptor type A	Homo sapiens	69-72
18071228-3	2007	After treating this electrode with water containing varied amounts of ribonuclease A (RNase A), the current peak based on 1 decreased with increasing in the amount of RNase A with a linear correlation in the range of 0.2-10 pg of RNase A.	Water	35-40	ribonuclease, RNase A family, 1 (pancreatic)	Mus musculus	70-84
8226786-1	1993	CHIP28 is a major water transporting protein in erythrocytes and plasma membranes in kidney proximal tubule and thin descending limb of Henle.	Water	18-23	aquaporin 1	Rattus norvegicus	0-6
8275028-0	1993	Simple purification and secondary structure evaluation of Sendai virus neuraminidase water soluble fragment.	Water	85-90	neuraminidase 1	Homo sapiens	71-84
18071228-3	2007	After treating this electrode with water containing varied amounts of ribonuclease A (RNase A), the current peak based on 1 decreased with increasing in the amount of RNase A with a linear correlation in the range of 0.2-10 pg of RNase A.	Water	35-40	ribonuclease, RNase A family, 1 (pancreatic)	Mus musculus	86-93
8275028-1	1993	We have developed a quick and simple method to purify the water soluble fragment of Sendai virus neuraminidase (cHN).	Water	58-63	neuraminidase 1	Homo sapiens	97-110
18071228-3	2007	After treating this electrode with water containing varied amounts of ribonuclease A (RNase A), the current peak based on 1 decreased with increasing in the amount of RNase A with a linear correlation in the range of 0.2-10 pg of RNase A.	Water	35-40	ribonuclease, RNase A family, 1 (pancreatic)	Mus musculus	167-174
8275028-1	1993	We have developed a quick and simple method to purify the water soluble fragment of Sendai virus neuraminidase (cHN).	Water	58-63	chimerin 1	Homo sapiens	112-115
18071228-3	2007	After treating this electrode with water containing varied amounts of ribonuclease A (RNase A), the current peak based on 1 decreased with increasing in the amount of RNase A with a linear correlation in the range of 0.2-10 pg of RNase A.	Water	35-40	ribonuclease, RNase A family, 1 (pancreatic)	Mus musculus	167-174
17983687-8	2007	A MD trajectory of the A7R/NRP-1 complex in explicit water, based on the recent tuftsin/NRP-1 crystal structure, has revealed the hydrogen-bonding network that contributes to A7R"s binding activity.	Water	53-58	neuropilin 1	Homo sapiens	27-32
8402636-8	1993	The bathochromic and hypochromic shift in the absorption spectrum of the water soluble compound TPT upon addition of CAF indicated that CAF and TPT interact (stack) in a fashion similar to that previously observed for CAF and DNA intercalators.	Water	73-78	lysine acetyltransferase 2B	Homo sapiens	117-120
8402636-8	1993	The bathochromic and hypochromic shift in the absorption spectrum of the water soluble compound TPT upon addition of CAF indicated that CAF and TPT interact (stack) in a fashion similar to that previously observed for CAF and DNA intercalators.	Water	73-78	lysine acetyltransferase 2B	Homo sapiens	136-139
8402636-8	1993	The bathochromic and hypochromic shift in the absorption spectrum of the water soluble compound TPT upon addition of CAF indicated that CAF and TPT interact (stack) in a fashion similar to that previously observed for CAF and DNA intercalators.	Water	73-78	lysine acetyltransferase 2B	Homo sapiens	136-139
8272411-0	1993	The effect of salts on the stability of beta-galactosidase in aqueous solution, as related to the water mobility.	Water	98-103	galactosidase beta 1	Homo sapiens	40-58
8241530-4	1993	In rats deprived of water for two days TRH completely prevented the decrease of neurohypophysial oxytocin due to stimulation of osmoreceptor origin.	Water	20-25	thyrotropin releasing hormone	Rattus norvegicus	39-42
17983687-8	2007	A MD trajectory of the A7R/NRP-1 complex in explicit water, based on the recent tuftsin/NRP-1 crystal structure, has revealed the hydrogen-bonding network that contributes to A7R"s binding activity.	Water	53-58	neuropilin 1	Homo sapiens	88-93
17929944-9	2007	Therefore, AN58 serves as a unique lead compound for developing water-soluble inhibitors with a nanomolar affinity for GluR2 AMPA receptors.	Water	64-69	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	119-124
8345200-3	1993	Together with vitronectin, clusterin binds to the nascent amphiphilic C5b-9 complex, rendering it water soluble and lytically inactive.	Water	98-103	clusterin	Homo sapiens	27-36
17681523-5	2007	Rapid demulsification could be induced by lowering the solution pH: addition of acid led to dissolution of the HAp nanoparticles attached on oil-water interface and the emulsion was destabilized.	Water	145-150	reticulon 3	Homo sapiens	111-114
8217517-1	1993	Effects of water activity (aw), pH and storage temperature on the growth of spores and vegetative cells of Bacillus spp.	Water	11-16	histocompatibility minor 13	Homo sapiens	116-119
17681523-8	2007	Sintering of methyl myristate-in-water emulsion stabilized with the HAp nanoparticles led to a porous HAp material.	Water	33-38	reticulon 3	Homo sapiens	68-71
17681523-8	2007	Sintering of methyl myristate-in-water emulsion stabilized with the HAp nanoparticles led to a porous HAp material.	Water	33-38	reticulon 3	Homo sapiens	102-105
8356032-1	1993	The X-ray structure of Escherichia coli TEM1 beta-lactamase has been refined to a crystallographic R-factor of 16.4% for 22,510 reflections between 5.0 and 1.8 A resolution; 199 water molecules and 1 sulphate ion were included in refinement.	Water	178-183	TEM-1 beta-lactamase	Escherichia coli	40-59
17877702-4	2007	The microfissure/dehydration phenotype is inherited as a single gene, termed Cwp1 (cuticular water permeability).	Water	93-98	transport and Golgi organization 2 homolog	Solanum lycopersicum	77-81
8366164-2	1993	Both XAD-2 and XAD-7 resin columns (20 ml) were capable of adsorbing about 30% of total organic halogen (TOX) present in 20 l of drinking water (pH 7) containing about 100 micrograms/l of TOX, whereas the carbon column (10 ml) adsorbed over 90% of TOX.	Water	138-143	thymocyte selection associated high mobility group box	Homo sapiens	105-108
17916764-11	2007	Stimulation of porcine brain capillary endothelial cells with H(2)O(2) increased permeability, an effect attenuated by inhibition of phosphatidyl inositol 3-kinase or c-Jun N-terminal kinase but not blockade of extracellular signal-regulated kinase-1/2 or p38 mitogen-activated protein kinase.	Water	62-67	mitogen-activated protein kinase 3	Mus musculus	211-252
24202502-8	1993	Glucagon inhibited INS-stimulated (3)H2O incorporation; whereas, GLU alone had no effect on lipid synthesis in liver pieces incubated 5h.	Water	37-40	glucagon	Bos taurus	0-8
8504772-1	1993	Physiological and ligand binding studies have shown that Angiotensin II (AII) exerts various functions along different segments of the nephron, via the type-1 receptor (AT1R), resulting in the control of glomerular filtration rate (GFR) and water and salt homeostasis.	Water	241-246	angiotensin II receptor, type 1a	Rattus norvegicus	169-173
17916764-11	2007	Stimulation of porcine brain capillary endothelial cells with H(2)O(2) increased permeability, an effect attenuated by inhibition of phosphatidyl inositol 3-kinase or c-Jun N-terminal kinase but not blockade of extracellular signal-regulated kinase-1/2 or p38 mitogen-activated protein kinase.	Water	62-67	mitogen-activated protein kinase 14	Mus musculus	256-259
17914811-6	2007	31Palpha-31Palpha EXSY cross-peaks indicate that the fac-[Re(CO)3(H2O)({Palpha,Pbeta}MDP)]- isomers interchange slowly on the NMR time scale, with an average k approximately equal to 0.8 s(-1) at 32 degrees C; the EXSY cross-peaks could arise from chirality changes at only Re(I) or at only Palpha.	Water	66-69	dipeptidase 1	Homo sapiens	85-88
17914811-10	2007	The similarity of the rate constants for interchange of fac-[Re(CO)3(H2O)({Palpha,Pbeta}MDP)]- and fac-[Re(CO)3(H2O)({N7,Pbeta}GDP)]- adducts suggest strongly that interchange of Pbeta and H2O coordination positions accounts for the EXSY cross-peaks present in the spectra of all adducts.	Water	69-72	dipeptidase 1	Homo sapiens	88-91
17898172-5	2007	Catalase (Cat), an antioxidant enzyme degrading H(2)O(2), shows an oscillating pattern of expression and activity, antiphasic to zCry1a and zPer2.	Water	48-53	cryptochrome circadian regulator 1a	Danio rerio	129-135
8131192-2	1993	The Hb A2 was determined by cellulose acetate haemoglobin electrophoresis in alkaline medium followed by elution in water.	Water	116-121	hemoglobin subunit alpha 2	Homo sapiens	4-9
17706244-3	2007	To that end, the water-soluble coenzyme Q(10) analogue CoQ(1) and a relatively high concentration of blood lymphocytes were combined in small quartz cuvettes so that the amount of blood needed for this assay remained low.	Water	17-22	decaprenyl diphosphate synthase subunit 1	Homo sapiens	55-61
17812226-4	1993	Reactions involving other hydrous minerals, including mica, epidote, chloritoid, and lawsonite, also release water over a wide depth interval, and in some subduction zones these phases may transport water to deep levels in the mantle.	Water	109-114	MHC class I polypeptide-related sequence A	Homo sapiens	54-58
8468540-6	1993	A survey of the literature suggests that, in Xenopus, as in the case of other less strictly water-dwelling amphibians, PRL is one of the hormones required for life in fresh water.	Water	92-97	prolactin, gene 1 L homeolog	Xenopus laevis	119-122
17985706-2	2007	In the study presented here, a steady-state approach was applied to obtain estimates of the transit time and concentration of the pesticide metabolite BAM (2,6-dichlorobenzoamide) at a site where it is contaminating a municipal drinking water supply.	Water	237-242	structural maintenance of chromosomes 3	Homo sapiens	151-154
8457558-1	1993	CHIP28k is an important water-transporting protein in the kidney proximal tubule and the thin descending limb of Henle [Zhang, Skach, Hasegawa, Van Hoek, &amp; Verkman (1993) J.	Water	24-29	aquaporin 1	Rattus norvegicus	0-6
8457558-8	1993	Oligonucleotide-directed mutagenesis was used to identify the cysteine(s) involved in inhibition of the water-transporting function of CHIP28k by the mercurial HgCl2.	Water	104-109	aquaporin 1	Rattus norvegicus	135-141
17729369-0	2007	Automated method for accurate abdominal fat quantification on water-saturated magnetic resonance images.	Water	62-67	FAT atypical cadherin 1	Homo sapiens	40-43
8381673-3	1993	Incubation with PLP of the water-soluble enzymatic domain of the neuraminidase has no effect on enzymatic activity, while the allosteric inhibition (Dallocchio et al.	Water	27-32	pyridoxal phosphatase	Homo sapiens	16-19
17729369-1	2007	PURPOSE: To introduce and evaluate the performance of an automated fat quantification method for water-saturated magnetic resonance images.	Water	97-102	FAT atypical cadherin 1	Homo sapiens	67-70
8381673-3	1993	Incubation with PLP of the water-soluble enzymatic domain of the neuraminidase has no effect on enzymatic activity, while the allosteric inhibition (Dallocchio et al.	Water	27-32	neuraminidase 1	Homo sapiens	65-78
17729369-2	2007	MATERIALS AND METHODS: A fat distribution model is proposed for fat quantification on water saturated magnetic resonance images.	Water	86-91	FAT atypical cadherin 1	Homo sapiens	25-28
17729369-2	2007	MATERIALS AND METHODS: A fat distribution model is proposed for fat quantification on water saturated magnetic resonance images.	Water	86-91	FAT atypical cadherin 1	Homo sapiens	64-67
8437114-3	1993	AHR-16329, a representative sulfamate, has an acidic (sulfonamide, pKa 8.9) and basic (imidazole, pKa 6.0) group and has desirable physicochemical properties for topical intraocular pressure lowering: good water solubility below pH 6.0, a CHCl3/buffer ratio of 0.5 at pH 7.0 and a Kl against CA-II of 7 nM.	Water	206-211	aryl hydrocarbon receptor	Homo sapiens	0-3
17729369-10	2007	CONCLUSION: The proposed automated method is simple, rapid, and accurate for fat quantification on water-saturated MR images.	Water	99-104	FAT atypical cadherin 1	Homo sapiens	77-80
17673668-5	2007	Apelin mutant mice are viable and fertile, appear healthy, and exhibit normal body weight, water and food intake, heart rates, and heart morphology.	Water	91-96	apelin	Mus musculus	0-6
8474696-0	1993	Reduced increase in plasma renin activity on water-deprivation in blind hereditary microphthalmic rats.	Water	45-50	renin	Rattus norvegicus	27-32
17558559-7	2007	While ARSA and ARSB are water-soluble enzymes, STS has a hydrophobic domain and is an integral membrane protein of the endoplasmic reticulum.	Water	24-29	arylsulfatase A	Homo sapiens	6-10
7693007-0	1993	Antarelix (EP 24332) a novel water soluble LHRH antagonist.	Water	29-34	gonadotropin releasing hormone 1	Homo sapiens	43-47
7693007-1	1993	A novel water soluble LHRH antagonist (EP 24332-Antarelix) is described.	Water	8-13	gonadotropin releasing hormone 1	Homo sapiens	22-26
2051123-2	1991	THM levels in drinking water samples from the same communities were compared but analysis of variance computations showed no significant correlation between the water and breast milk.	Water	23-28	THM	Homo sapiens	0-3
17715681-6	2007	A novel water-soluble forskolin derivative, colforsin daropate hydrochloride (CDH) is a positive inotropic agent for treatment of the heart failure, especially in the severe stage with the beta1 AR desensitization.	Water	8-13	adrenoceptor beta 1	Homo sapiens	189-197
1871781-4	1991	When the sulfates were hydrolyzed in 18O-water, the heavy-oxygen atom was shown to be incorporated quantitatively into the C-6 position of the products.	Water	41-46	complement C6	Homo sapiens	123-126
7678419-0	1993	CHIP28 water channels are localized in constitutively water-permeable segments of the nephron.	Water	7-12	aquaporin 1	Rattus norvegicus	0-6
7678419-0	1993	CHIP28 water channels are localized in constitutively water-permeable segments of the nephron.	Water	54-59	aquaporin 1	Rattus norvegicus	0-6
7678419-2	1993	CHIP28 is a 28-kD integral protein which was proposed to mediate transmembrane water movement in red cells and kidney (Preston, G. M., T. P. Carroll, W. B. Guggino, and P. Agre.	Water	79-84	aquaporin 1	Rattus norvegicus	0-6
7678419-12	1993	CHIP28 was not detected in ascending thin limbs, thick ascending limbs, or distal tubules, which are highly impermeable to water.	Water	123-128	aquaporin 1	Rattus norvegicus	0-6
7678419-13	1993	Moreover, CHIP28 was not detected in collecting duct epithelia, where water permeability is regulated by antidiuretic hormone.	Water	70-75	aquaporin 1	Rattus norvegicus	10-16
1897936-4	1991	The inhibition was reversible, it occurred at a site preceding Tyrz (Tyr residue mediating electron transfer from H2O to photosystem 2), and it interfered noncompetitively with the reactivation of incompetent dPS2 with Cl-.	Water	114-117	inflated	Drosophila melanogaster	209-213
7678419-14	1993	These determinations of abundance and structural organization provide evidence that the CHIP28 water channel is the predominant pathway for constitutive transepithelial water transport in the proximal tubule and descending limb of Henle"s loop.	Water	95-100	aquaporin 1	Rattus norvegicus	88-94
17616158-1	2007	Multilayers consisting of negatively charged phospholipid DMPA and myelin basic protein (MBP) were assembled by Langmuir-Blodgett deposition of floating Langmuir monolayers from the air/water interface to solid substrates.	Water	186-191	myelin basic protein	Homo sapiens	89-92
7678419-14	1993	These determinations of abundance and structural organization provide evidence that the CHIP28 water channel is the predominant pathway for constitutive transepithelial water transport in the proximal tubule and descending limb of Henle"s loop.	Water	169-174	aquaporin 1	Rattus norvegicus	88-94
7679139-2	1993	The effects of GH on individual body compartments--water, fat, protein and mineral--are achieved both by the action of GH and by a GH-induced hormone, insulin-like growth factor-I (IGF-I).	Water	51-56	insulin-like growth factor 1	Mus musculus	151-179
8430045-2	1993	Inactivation of beta-galactosidase lyophilized from phosphate buffer solution was studied as a function of water content, which in turn affected the T1 of water.	Water	107-112	galactosidase beta 1	Homo sapiens	16-34
2034822-7	1991	We conclude that water immersion and restraint stress is accompanied by an excessive release of EGF, which appears to attenuate gastric secretion, enhances the DNA synthesis and may limit the formation of stress-induced gastric ulcerations.	Water	17-22	epidermal growth factor like 1	Rattus norvegicus	96-99
8430045-2	1993	Inactivation of beta-galactosidase lyophilized from phosphate buffer solution was studied as a function of water content, which in turn affected the T1 of water.	Water	155-160	galactosidase beta 1	Homo sapiens	16-34
17616158-10	2007	Here, the water molecules were found to be a necessary mediator to maintain the laminar order in a multilayer from DMPA and myelin basic protein.	Water	10-15	myelin basic protein	Homo sapiens	124-144
8430045-3	1993	An increase in the water content of freeze-dried beta-galactosidase brought about an increase in the T1 of water, as well as a rise in pH.	Water	19-24	galactosidase beta 1	Homo sapiens	49-67
8430045-3	1993	An increase in the water content of freeze-dried beta-galactosidase brought about an increase in the T1 of water, as well as a rise in pH.	Water	107-112	galactosidase beta 1	Homo sapiens	49-67
15092109-5	1991	The losses of PAH compounds in these field experiments can be related, in part, to their physico-chemical properties, notably the octanol: water partition coefficient.	Water	139-144	phenylalanine hydroxylase	Homo sapiens	14-17
8430045-7	1993	Inactivation of beta-galactosidase in solutions was also studied as a function of phosphate buffer and sodium chloride concentrations, which in turn affected the T1 of water.	Water	168-173	galactosidase beta 1	Homo sapiens	16-34
17575980-4	2007	Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively.	Water	121-126	aquaporin 10	Homo sapiens	44-56
1476771-5	1992	In turn, PHB may be rendered soluble in aqueous media by complexation to water-soluble proteins, such as serum lipoproteins and albumin.	Water	73-78	prohibitin 1	Homo sapiens	9-12
1775509-4	1991	TRH was dissolved by sonification (10 mg/l) and was stable in tap water.	Water	66-71	thyrotropin releasing hormone	Rattus norvegicus	0-3
1775509-11	1991	To improve the stability of TRH in tap water, 1-ml samples of drinking water with dissolved TRH were measured.	Water	39-44	thyrotropin releasing hormone	Rattus norvegicus	28-31
1775509-11	1991	To improve the stability of TRH in tap water, 1-ml samples of drinking water with dissolved TRH were measured.	Water	71-76	thyrotropin releasing hormone	Rattus norvegicus	92-95
17463181-7	2007	Leptin repletion upregulated the expression of aquaporin 1 water channel by 1.3-fold and downregulated aquaporin 4 by 2.3-fold.	Water	59-64	aquaporin 1	Mus musculus	47-58
2281947-1	1990	Activation of the renin-angiotensin system has been shown to arouse both water and sodium intake in the rat.	Water	73-78	renin	Rattus norvegicus	18-23
1279809-4	1992	CFTR has a calculated single channel water conductance of 9 x 10(-13) cubic centimeter per second, suggesting a pore-like aqueous pathway.	Water	37-42	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	Xenopus laevis	0-4
1279809-6	1992	Thus CFTR contains a cAMP-stimulated aqueous pore that can transport anions, water, and small solutes.	Water	77-82	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	Xenopus laevis	5-9
17480054-1	2007	The PST-01 protease is a metalloprotease that has zinc ion at the active center and is very stable in the presence of water-soluble organic solvents.	Water	118-123	sulfotransferase family 1A member 1	Homo sapiens	4-7
1447568-1	1992	Exchange-inert beta, gamma-bidentate Cr(H2O)x(NH3)y ATP complexes inactivate yeast phosphoglycerate kinase (PGK) by forming a coordination complex at the enzyme active site.	Water	40-43	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	83-106
1447568-1	1992	Exchange-inert beta, gamma-bidentate Cr(H2O)x(NH3)y ATP complexes inactivate yeast phosphoglycerate kinase (PGK) by forming a coordination complex at the enzyme active site.	Water	40-43	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	108-111
1393612-2	1992	The AT-1 receptor blocker, losartan potassium (DUP 753), inhibited water intake evoked by central administration of AII, with the 50% inhibitory dose being less than 0.1 microgram.	Water	67-72	angiotensin II receptor, type 1a	Rattus norvegicus	4-8
1393612-7	1992	These data suggest that both AT-1 and AT-2 receptor subtypes in the brain are involved in angiotensin-related water and NaCl intakes.	Water	110-115	angiotensin II receptor, type 1a	Rattus norvegicus	29-33
24420580-5	1990	The magnetic resonance properties of Chl a/water aggregates have provided the basis for the special pair concept for the primary electron donor in photosynthesis.	Water	43-48	chordin like 1	Homo sapiens	37-40
17372987-0	2007	Water soluble fraction of solar-simulated light-exposed crude oil generates phosphorylation of histone H2AX in human skin cells under UVA exposure.	Water	0-5	H2A.X variant histone	Homo sapiens	103-107
2201684-2	1990	As determined by EPR and by 1/T1 measurements of water protons, whole Pol I binds Mn2+ at one tight site (KD = 2.5 microM) and approximately 20 weak sites (KD = 600 microM).	Water	49-54	DNA polymerase iota	Homo sapiens	70-75
1529180-8	1992	We concluded that water intoxication was the cause of the ECG change and the elevated serum CPK, GOT and LDH levels.	Water	18-23	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	92-95
1529180-9	1992	There are few reports on elevated CPK level in association with water intoxication, in which rhabdomyolysis is speculated as the cause of CPK elevation.	Water	64-69	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	34-37
1529180-9	1992	There are few reports on elevated CPK level in association with water intoxication, in which rhabdomyolysis is speculated as the cause of CPK elevation.	Water	64-69	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	138-141
1515067-1	1992	The purification procedure of cathepsin S includes acid activation of spleen homogenate, incubation at 37 degrees C, precipitation with (NH4)2SO4 in H2O/tert-butanol medium, gel chromatography, chromatofocusing, covalent chromatography and cation chromatography of FPLC system.	Water	149-152	cathepsin S	Bos taurus	30-41
17372987-3	2007	In this study, we found that the water soluble fraction (WSF) of crude oil irradiated with solar-simulated light (SSL) generated phosphorylation of histone H2AX (gamma-H2AX) in human skin cells under UVA irradiation, which was due to the formation of DNA double strand breaks (DSBs).	Water	33-38	H2A.X variant histone	Homo sapiens	148-160
1583405-2	1992	Injection of distilled water (4 ml within 5 seconds) into the carotid arteries of rats resulted in intravascular hemolysis leading to hemoglobinemia, hemoglobinuria, reduction in inulin clearance, and elevation of urine N-acetyl-beta-D-glucosaminidase (NAG) excretion.	Water	23-28	O-GlcNAcase	Rattus norvegicus	220-251
17372987-3	2007	In this study, we found that the water soluble fraction (WSF) of crude oil irradiated with solar-simulated light (SSL) generated phosphorylation of histone H2AX (gamma-H2AX) in human skin cells under UVA irradiation, which was due to the formation of DNA double strand breaks (DSBs).	Water	33-38	H2A.X variant histone	Homo sapiens	162-172
2223521-9	1990	In mineral water, bottled into thoroughly cleaned glass bottles, colony counts of more than 10(5) cfu ml-1 were found within 4 days.	Water	11-16	interleukin 17F	Homo sapiens	102-106
17318528-9	2007	The binding of the mimotopes to the Fab part of the IgG1 antibody and binding of SpA to the Fc part of the IgG1 antibody were mainly driven by hydrophobic effects and associated with a relatively large change in water-accessible surface area.	Water	212-217	surfactant protein A1	Homo sapiens	81-84
1695239-5	1990	Circular dichroism and Fourier-transform infrared of these MBP peptides in water demonstrated random structure that was partially changed to beta-structure in the shorter peptides.	Water	75-80	myelin basic protein	Homo sapiens	59-62
1615059-5	1992	In addition, SAM-P/8 mice exhibited a significant increase in punished water drinking compared to SAM-R/1 mice in the water-lick conflict test, although unpunished water intake in SAM-P/8 mice did not differ from that in the SAM-R/1 control.	Water	71-76	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	Mus musculus	13-20
1615059-5	1992	In addition, SAM-P/8 mice exhibited a significant increase in punished water drinking compared to SAM-R/1 mice in the water-lick conflict test, although unpunished water intake in SAM-P/8 mice did not differ from that in the SAM-R/1 control.	Water	118-123	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	Mus musculus	13-20
1615059-5	1992	In addition, SAM-P/8 mice exhibited a significant increase in punished water drinking compared to SAM-R/1 mice in the water-lick conflict test, although unpunished water intake in SAM-P/8 mice did not differ from that in the SAM-R/1 control.	Water	118-123	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	Mus musculus	13-20
17393253-0	2007	Heterogeneity of proteinase inhibitors in the water-soluble organic matrix from the oyster nacre.	Water	46-51	endogenous retrovirus group K member 7	Homo sapiens	17-27
2172040-7	1990	The 10 or 15 cm H2O pressure increased the secretion debit of amylase, lipase and proteinase whereas a higher pressure suppressed their secretion.	Water	16-19	pancreatic lipase related protein 1	Canis lupus familiaris	71-77
17393253-1	2007	We extracted proteinase inhibitors from the nacre of the oyster Pinctada margaritifera with water.	Water	92-97	endogenous retrovirus group K member 7	Homo sapiens	13-23
1347739-4	1992	H2O-injected control rats exhibited the typical cyclic responsiveness to GRF stimulation, with GRF-induced GH release significantly greater during peak compared to trough periods of the GH rhythm.	Water	0-3	growth hormone releasing hormone	Rattus norvegicus	73-76
18180218-12	2007	The highest concentrations of Giardia spp cysts were 560 cysts/L in the surface water and 650 cysts/L in the residual effluent, while the corresponding figures for Cryptosporidium spp were 1,110 oocysts/L in the stream and 1,500 oocysts/L in the effluent.	Water	80-85	histocompatibility minor 13	Homo sapiens	38-41
1347739-4	1992	H2O-injected control rats exhibited the typical cyclic responsiveness to GRF stimulation, with GRF-induced GH release significantly greater during peak compared to trough periods of the GH rhythm.	Water	0-3	growth hormone releasing hormone	Rattus norvegicus	95-98
1347739-4	1992	H2O-injected control rats exhibited the typical cyclic responsiveness to GRF stimulation, with GRF-induced GH release significantly greater during peak compared to trough periods of the GH rhythm.	Water	0-3	gonadotropin releasing hormone receptor	Rattus norvegicus	186-188
1347739-5	1992	Pretreatment with rhGH 3 h before GRF injection markedly inhibited the GH response to GRF at a peak time [integrated GH release over 30 min, 1135 +/- 271 vs. 6372 +/- 1185 ng/ml.30 min in H2O-injected controls (mean +/- SE); P less than 0.01].	Water	188-191	gonadotropin releasing hormone receptor	Rattus norvegicus	20-22
1347739-5	1992	Pretreatment with rhGH 3 h before GRF injection markedly inhibited the GH response to GRF at a peak time [integrated GH release over 30 min, 1135 +/- 271 vs. 6372 +/- 1185 ng/ml.30 min in H2O-injected controls (mean +/- SE); P less than 0.01].	Water	188-191	growth hormone releasing hormone	Rattus norvegicus	86-89
1347739-5	1992	Pretreatment with rhGH 3 h before GRF injection markedly inhibited the GH response to GRF at a peak time [integrated GH release over 30 min, 1135 +/- 271 vs. 6372 +/- 1185 ng/ml.30 min in H2O-injected controls (mean +/- SE); P less than 0.01].	Water	188-191	gonadotropin releasing hormone receptor	Rattus norvegicus	71-73
1347739-6	1992	In striking contrast, 5 h after rhGH administration, there was a 6-fold augmentation of GH responsiveness to GRF compared to that in H2O-injected controls at a trough time (7032 +/- 1622 vs. 1128 +/- 216 ng/ml.30 min; P less than 0.01).	Water	133-136	growth hormone releasing hormone	Rattus norvegicus	109-112
1347739-8	1992	Passive immunization of rhGH-treated rats with SRIF antiserum reversed the rhGH-induced blunted GH response at 3 h (7985 +/- 366 vs. 1705 +/- 431 ng/ml.30 min in rhGH-treated control rats given normal sheep serum; P less than 0.01) and completely restored GH responsiveness to levels as high as those in H2O-injected controls.	Water	304-307	gonadotropin releasing hormone receptor	Rattus norvegicus	26-28
1347739-8	1992	Passive immunization of rhGH-treated rats with SRIF antiserum reversed the rhGH-induced blunted GH response at 3 h (7985 +/- 366 vs. 1705 +/- 431 ng/ml.30 min in rhGH-treated control rats given normal sheep serum; P less than 0.01) and completely restored GH responsiveness to levels as high as those in H2O-injected controls.	Water	304-307	gonadotropin releasing hormone receptor	Rattus norvegicus	77-79
1699110-9	1990	The fourfold reduction of alpha 1I3 mRNA concentrations in FAO1 cells could be reversed by treatment with 1 microM of a water-soluble derivative of forskolin, an activator of the cyclic AMP pathway.	Water	120-125	alpha-1-inhibitor III	Rattus norvegicus	26-35
2185623-5	1990	Ingestion of 300 mL water in four subjects resulted in a mean decrease of 3.4 nmol PLP/L plasma and indicated that some but not all of the decrease may have been due to fluid ingestion per se.	Water	20-25	coiled-coil domain containing 177	Homo sapiens	83-88
17631809-10	2007	RESULTS: The content of IL-8 in tumor tissue of the untreated group was significantly higher than that of the other groups (P&lt;0.01), and that of the cold water-treated group was higher than that of the cold water and WZXTR-treated group (P&lt;0.01) and the cold water and XTSJR-treated group (P&lt;0.05), respectively.	Water	157-162	chemokine (C-X-C motif) ligand 15	Mus musculus	24-28
17566653-2	2007	We investigated whether the immunolocalization of two water channels, AQP1 and AQP4, alters in the rat retina during experimental diabetes.	Water	54-59	aquaporin 1	Rattus norvegicus	70-74
1694105-2	1990	After prolonged administration of 2% sodium chloride as drinking water (salt-loading), the treatment increased the levels of VP, OXY, TH, GAL, DYN and CCK mRNA in the PVN and SON.	Water	65-70	tyrosine hydroxylase	Rattus norvegicus	134-136
2142376-5	1990	Treatment of surface-bound 125I-IL-1 alpha with a bivalent water-soluble cross-linker identified a membrane peptide of Mr 70,000 cross-linked to IL-1.	Water	59-64	interleukin 1 complex	Mus musculus	32-36
1558873-3	1992	The extract of boiling water of the herbal prescription (P-3) was first fractionated by ether into an acidic fraction and a mixture of basic and neutral fractions.	Water	23-28	solute carrier family 10 (sodium/bile acid cotransporter family), member 3	Mus musculus	57-60
1310028-0	1992	Redox-dependent changes in beta-extended chain and turn structures of cytochrome c in water solution determined by second derivative amide I infrared spectra.	Water	86-91	LOC104968582	Bos taurus	70-82
17523628-2	2007	In the trinitrate, the eta(2)-coordination is clearly favored in water and in the gas phase, leading to a coordination number (CN) of 6.	Water	65-70	DNA polymerase iota	Homo sapiens	23-29
1424736-5	1992	Our study demonstrates that another photoreceptor cell protein, phosducin, is capable of eliciting EAU and EAP.	Water	99-102	phosducin	Rattus norvegicus	64-73
17523628-7	2007	-3 kcal/mol is predicted for the eta(2)- to eta(1)- transition in water.	Water	66-71	DNA polymerase iota	Homo sapiens	33-39
17434681-8	2007	Pretreatment of the LPBN with the 5-HT3 receptor antagonist, 1-methyl-N-[8-methyl-8-azabicyclo (3.2.1)-oct-3-yl]-1H-indazole-3-carboxamide (LY-278,584) abolished the effects of PBG, but LY-278,584 had no effects on sodium or water intake when injected by itself.	Water	225-230	5-hydroxytryptamine receptor 3A	Rattus norvegicus	34-48
1356240-4	1992	Brain synaptosomes from rats with a 21-day CRF have a significantly (p less than 0.01) lower Vmax of TH (39.5 +/- 5.3 pmol tritiated H2O/mg protein/min) than that of normal rats (61.	Water	133-136	tyrosine hydroxylase	Rattus norvegicus	101-103
17397903-2	2007	The prepared magnetic composites can be used to adsorb acid orange II (AO7) in water and subsequently, easily be separated from the medium by a magnetic technique.	Water	79-84	ring finger protein 25	Homo sapiens	71-74
1356240-6	1992	Parathyroidectomy (PTX) in CRF rats normalized Vmax of TH (54 +/- 4.5 pmol tritiated H2O/mg protein) and Km of MAO (48.4 +/- 2.3 nM tyramine).	Water	85-88	tyrosine hydroxylase	Rattus norvegicus	55-57
1410435-1	1992	The atrial natriuretic factor (ANF) as an osmoregulatory hormone causes a reduction of extracellular fluid volume primarily through stimulation of renal and extrarenal water and sodium elimination.	Water	168-173	natriuretic peptides A	Oryctolagus cuniculus	4-29
17286974-0	2007	Changes of PACAP levels in the brain show gender differences following short-term water and food deprivation.	Water	82-87	adenylate cyclase activating polypeptide 1	Rattus norvegicus	11-16
1410435-1	1992	The atrial natriuretic factor (ANF) as an osmoregulatory hormone causes a reduction of extracellular fluid volume primarily through stimulation of renal and extrarenal water and sodium elimination.	Water	168-173	natriuretic peptides A	Oryctolagus cuniculus	31-34
1307842-0	1992	[Measuring enzymatic activities in vivo as an aid in water monitoring].	Water	53-58	activation induced cytidine deaminase	Homo sapiens	46-49
17286974-6	2007	Our results show that levels of PACAP decreased in the hypothalamus in both sexes after water deprivation, with a more marked, significant decrease in females at 12h.	Water	88-93	adenylate cyclase activating polypeptide 1	Rattus norvegicus	32-37
17286974-12	2007	Our results show a sensitive reaction in changes of endogenous PACAP levels to water and food deprivation in most brain areas, but they are differentially regulated in male and female rats.	Water	79-84	adenylate cyclase activating polypeptide 1	Rattus norvegicus	63-68
17526885-10	2007	The water consumption of the FFR-producing units was remarkably smaller than that of IC due to the large volumes of water consumed in forage crop production.	Water	4-9	VPS51 subunit of GARP complex	Homo sapiens	29-32
1763058-6	1991	These studies have demonstrated the presence of two AII receptor subtypes in the brain, one (AT1) in areas related to regulation of blood pressure, water intake, and pituitary hormone secretion, and one (AT2) whose function is not yet defined.	Water	148-153	angiotensin II receptor, type 1a	Rattus norvegicus	93-96
1940310-1	1991	To localize the highly water-soluble major allergen Bet v I in ultra-thin sections of birch pollen, pollen grains were cracked, air-dried, and processed for electron microscopy using one of the following preparation techniques: fixation in aqueous p-formaldehyde + cetylpyridinium chloride; fixation in p-formaldehyde vapor; fixation in benzoquinone vapor; inert dehydration; or no fixation.	Water	23-28	delta/notch like EGF repeat containing	Homo sapiens	52-55
17526885-10	2007	The water consumption of the FFR-producing units was remarkably smaller than that of IC due to the large volumes of water consumed in forage crop production.	Water	116-121	VPS51 subunit of GARP complex	Homo sapiens	29-32
17371871-1	2007	In the brain, aquaporin-1 (AQP-1), a water channel for high osmotic water permeability, is mainly expressed in the apical membrane of the ventricular choroid plexus and regulates formation of cerebrospinal fluid (CSF).	Water	37-42	aquaporin 1	Rattus norvegicus	14-25
1659683-3	1991	Intestinal H2O, Na+, and glucose absorption expressed per cm of intestine were significantly increased in animals receiving EGF by either route.	Water	11-14	pro-epidermal growth factor	Oryctolagus cuniculus	124-127
1920440-6	1991	Water molecules interacting with alpha-helices occur mainly at the amino and carbonyl termini of the helices, in which case the solvent sites maintain the hydrogen bonding by bridging between residues i and i-3 or i-4 at the amino terminus and between i and i+3 or i+4 at the carbonyl terminus.	Water	0-5	brain protein I3	Homo sapiens	207-210
17371871-1	2007	In the brain, aquaporin-1 (AQP-1), a water channel for high osmotic water permeability, is mainly expressed in the apical membrane of the ventricular choroid plexus and regulates formation of cerebrospinal fluid (CSF).	Water	37-42	aquaporin 1	Rattus norvegicus	27-32
17371871-1	2007	In the brain, aquaporin-1 (AQP-1), a water channel for high osmotic water permeability, is mainly expressed in the apical membrane of the ventricular choroid plexus and regulates formation of cerebrospinal fluid (CSF).	Water	68-73	aquaporin 1	Rattus norvegicus	14-25
17371871-1	2007	In the brain, aquaporin-1 (AQP-1), a water channel for high osmotic water permeability, is mainly expressed in the apical membrane of the ventricular choroid plexus and regulates formation of cerebrospinal fluid (CSF).	Water	68-73	aquaporin 1	Rattus norvegicus	27-32
17408256-10	2007	Furthermore, the spectral contribution of the stretching of H-bonds between water molecules and PF6- cannot be unambiguously detected, which indicates an extremely weak interaction between water molecules and this anion.	Water	76-81	sperm associated antigen 17	Homo sapiens	96-99
1916149-3	1991	Water-immersion caused a significant decrease immunoreactive-TRH (ir-TRH) concentrations in the stomach, and a significant increase in ir-TRH concentrations in the gastric juice.	Water	0-5	thyrotropin releasing hormone	Rattus norvegicus	61-64
1916149-3	1991	Water-immersion caused a significant decrease immunoreactive-TRH (ir-TRH) concentrations in the stomach, and a significant increase in ir-TRH concentrations in the gastric juice.	Water	0-5	thyrotropin releasing hormone	Rattus norvegicus	69-72
1916149-3	1991	Water-immersion caused a significant decrease immunoreactive-TRH (ir-TRH) concentrations in the stomach, and a significant increase in ir-TRH concentrations in the gastric juice.	Water	0-5	thyrotropin releasing hormone	Rattus norvegicus	69-72
17408256-10	2007	Furthermore, the spectral contribution of the stretching of H-bonds between water molecules and PF6- cannot be unambiguously detected, which indicates an extremely weak interaction between water molecules and this anion.	Water	189-194	sperm associated antigen 17	Homo sapiens	96-99
17215329-0	2007	Interplay between TonEBP and calcineurin-NFATc signaling pathways: a means of optimizing water reabsorption?	Water	89-94	nuclear factor of activated T cells 5	Homo sapiens	18-24
2069576-1	1991	We have recorded 1H NMR spectra in H2O for exchangeable protons of four pyridoxal phosphate-dependent enzymes: D-serine dehydratase, aspartate aminotransferase, tryptophan: indole-lyase and glutamate decarboxylase.	Water	35-38	serine racemase	Homo sapiens	111-131
17229676-0	2007	COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction.	Water	52-57	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5
2061317-9	1991	In EP cells incubated at 1.8 mM Ca2+ the water-soluble products of choline metabolism (choline, P-choline, CDP-choline, and glycerophosphocholine) were retained at 37 degrees C; in contrast, in the presence of 100 nM Ca2+ there was uniform leakage of these metabolites.	Water	41-46	cut like homeobox 1	Homo sapiens	107-110
17377981-6	2007	In the postnatal lens, the increase in membrane water permeability of epithelial cells and lens transparency coincides with the increase in AQP1 expression.	Water	48-53	aquaporin 1	Mus musculus	140-144
2037560-1	1991	The purpose of this work was to investigate whether biotin, a water-soluble vitamin, regulates the glucokinase gene.	Water	62-67	glucokinase	Rattus norvegicus	99-110
2058670-5	1991	In vivo studies showed that the addition of 60 ng/ml EGF to the perfusate resulted in increased absorption of H2O, Na+, Cl-, and glucose from the jejunum.	Water	110-113	pro-epidermal growth factor	Oryctolagus cuniculus	53-56
17303660-10	2007	These results suggested that the effect of AVP on water recruitment was disturbed in V1aR(-/-) mice.	Water	50-55	arginine vasopressin	Mus musculus	43-46
2024817-9	1991	The appearance of pulmonary arterial hypertension, increased lung water, decreased lung compliance, and deteriorating gas exchange was correlated with the rise in plasma TNF activity, which reached a peak at 90 to 120 min in septic pigs.	Water	66-71	tumor necrosis factor	Sus scrofa	170-173
1716401-3	1991	Furthermore, the Zn-inhibitable MBP-degrading activity was found to be water-soluble and able to recognize MBP also if this protein was protected by its lipidic environment in the native-like, lipid-bound form.	Water	71-76	myelin basic protein	Homo sapiens	32-35
1900511-2	1991	One water is tightly bound to Asp76(O delta), Thr93(O gamma), Cys6(O), and Asn9(N); another bridges two loops by hydrogen-bonding to Tyr68(O eta) and to Ser35(N), Asn36(N); a loop structure is stabilized by two waters coordinated to Gly31(O) and His27(N delta), and by water bound to cis-Pro39(O).	Water	4-9	endothelin receptor type A	Homo sapiens	141-144
1993499-5	1991	Elastase 1 thus seems to fulfill the important function of maintaining water solubility of neutral sterols at low bile acid concentrations.	Water	71-76	chymotrypsin like elastase 1	Homo sapiens	0-10
1997319-1	1991	Water soluble 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide was used to internally cross-link carboxyl and lysyl groups of caldesmon.	Water	0-5	caldesmon 1	Gallus gallus	123-132
1831170-9	1991	It is possible that endogenous DA, stimulating DA1 receptors in the rat kidney may be an important factor involved in the Na+, K+ and water excretion evoked by furosemide.	Water	134-139	RT1 class II, locus Da	Rattus norvegicus	47-50
1805512-3	1991	The ionization constants of primaquine in 50% (v/v) ethanol in water determined at 25 degrees C in the ionic strength range of 5 x 10(-3)-5 x 10(-2) mol/L are: Ka1 = (3.84 +/- 2.35) x 10(-2) (attributed to the secondary ammonium group of primaquine); Ka2 = (1.50 +/- 1.17) x 10(-8) (attributed to the tertiary ammonium group); Ka3 = (2.07 +/- 0.27) x 10(-10) (attributed to the primary ammonium group).	Water	63-68	glutamate ionotropic receptor kainate type subunit 5	Homo sapiens	251-254
2269260-4	1990	To compare in vivo and in vitro results, the specimens were suspended in a water-filled tank and 2DE images were made using the same transducer positions as in life.	Water	75-80	TRAF family member associated NFKB activator	Equus caballus	88-98
2253909-3	1990	During in vivo jejunal perfusion studies we found that (i) a polyunsaturated fat (corn oil) supplemented diet improves jejunal absorption of water and electrolytes and these changes are independent of the observed concentrations of luminal prostaglandins; (ii) high dietary fat appreciably reduced the secretory response to cholera toxin, probably without fundamentally changing the mechanism by which cholera toxin induces secretion.	Water	141-146	FAT atypical cadherin 1	Rattus norvegicus	77-80
2205108-5	1990	During conversion of alanine to lactate with glutamic-pyruvic transaminase (GPT) and lactate dehydrogenase (LDH) in vitro, 32 +/- 2% of 3H in [3-3H]alanine was found in water and 68 +/- 2% in lactate.	Water	169-174	glutamic--pyruvic transaminase	Homo sapiens	45-74
2205108-5	1990	During conversion of alanine to lactate with glutamic-pyruvic transaminase (GPT) and lactate dehydrogenase (LDH) in vitro, 32 +/- 2% of 3H in [3-3H]alanine was found in water and 68 +/- 2% in lactate.	Water	169-174	glutamic--pyruvic transaminase	Homo sapiens	76-79
2361155-7	1990	Analysis of the Li-B-DNA x-ray diffraction intensities reveals those two water positions in the minor groove.	Water	73-78	leucine rich repeat containing 15	Homo sapiens	16-20
2194033-0	1990	Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action.	Water	0-5	renin	Rattus norvegicus	14-19
2382514-5	1990	Cathepsin D activity was maximal when incubated at 33 to 53 degrees C, was affected by a decrease in water activity and unaffected by pressure.	Water	101-106	cathepsin D	Homo sapiens	0-11
2378873-1	1990	The second-order rate constants for reaction of the Mg2+ complexes of phosphorylated pyridine monoanions with Mg(OH)+ are 10(4)-10(6)-fold larger than the second-order rate constants for their reaction with water (25 degrees C, ionic strength 1.5).	Water	207-212	mucin 7, secreted	Homo sapiens	52-55
2378873-2	1990	Of the 10(6)-fold rate enhancement with the phosphorylated 4-morpholinopyridine/Mg2 complex, approximately 10(4)-fold is attributed to the greater nucleophilicity of Mg(OH)+ compared with water.	Water	188-193	mucin 7, secreted	Homo sapiens	80-83
2367553-1	1990	We measured concentration changes of the fluorescence quantum yield eta/eta 0 of flavomononucleotide (FMN) in glycerine-water solutions of various viscosities.	Water	120-125	endothelin receptor type A	Homo sapiens	68-71
2333736-3	1990	The results show that excess drinking, induced by substitution of drinking water by a 5% glucose solution, causes a rapid increase in POMC synthesis, whereas dehydration has the opposite effect; no evidence could be found that the above treatments have any effect on the processing of POMC, although strain differences were found in level of N-terminal acetylation of newly synthesized melanotropins and endorphins.	Water	75-80	pro-opiomelanocortin-alpha	Mus musculus	134-138
2109932-8	1990	Delivery of water from the proximal straight segment, as estimated from CLi/CIn, increased in proportion to the delivery from the convoluted segment, as estimated from 1/(TF/P)In.	Water	12-17	pyridoxal phosphatase	Homo sapiens	76-79
1669476-3	1990	Intra-amygdaloid TRH injection to submissive rats resulted in a loss of subordinate position in these animals in the water competition test.	Water	117-122	thyrotropin releasing hormone	Rattus norvegicus	17-20
2237363-4	1990	After a one-day water storage the lowest bond strength was obtained with ABC-Cement and the highest with Superbond and Comspan opaque, independent of the interval between silicoating and bonding.	Water	16-21	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	73-76
33772997-2	2021	Here, we design a low-concentration aqueous Zn(OTF)2-Zn(NO3)2 electrolyte to in situ form a robust inorganic ZnF2-Zn5(CO3)2(OH)6-organic bi-layer SEI where the inorganic inner layer promotes Zn-ion diffusion while the organic outer layer suppresses water penetration.	Water	249-254	zinc finger protein 2	Homo sapiens	109-113
33779289-7	2021	Brain water content was significantly reduced in ASIC1a-/- animals compared to wild-type controls.	Water	6-11	acid-sensing (proton-gated) ion channel 1	Mus musculus	49-55
33812059-2	2021	However, feeding in the presence of fructose in water suppressed glycogen accumulation in the liver by up-regulating the expression of glucose-6-phosphatase catalytic subunit (G6pc) gene although the exact mechanism is unknown.	Water	48-53	glucose-6-phosphatase, catalytic	Mus musculus	135-174
33812059-2	2021	However, feeding in the presence of fructose in water suppressed glycogen accumulation in the liver by up-regulating the expression of glucose-6-phosphatase catalytic subunit (G6pc) gene although the exact mechanism is unknown.	Water	48-53	glucose-6-phosphatase, catalytic	Mus musculus	176-180
2303446-13	1990	This result suggests that a major kinetic barrier for O2 and CO binding to native myoglobin may involve disruption of polar interactions between His64 and water molecules found in the distal pocket of deoxymyoglobin.	Water	155-160	myoglobin	Physeter catodon	82-91
2323808-1	1990	Human colonic mucin has been isolated from normal colonic mucosa by a phenol-water extraction procedure and purified by Sepharose 2B column chromatography.	Water	77-82	LOC100508689	Homo sapiens	14-19
2187918-2	1990	Aldicarb and atrazine along with the soil fumigants EDB and DCP and DBCP have been the pesticides most frequently detected in ground water.	Water	133-138	vesicle associated membrane protein 8	Homo sapiens	52-55
2406422-5	1990	However, immersion in water for 6 months caused a significant decrease in the strength of the bond of specimens adhered with ABC cement.	Water	22-27	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	125-128
2089888-7	1990	When pHi approaches normal there will be a net extrusion of Na+, taking osmotic water with it, and presumably with passive washout of lactate.	Water	80-85	glucose-6-phosphate isomerase	Homo sapiens	5-8
2148901-4	1990	These results demonstrate that this spa water, despite its high arsenic content, is not toxic and does not interfere with the immune system of healthy mice.	Water	40-45	surfactant associated protein A1	Mus musculus	36-39
2110396-2	1990	In order to control virological aspects of water quality realistic and practicable monitoring procedures, esp.	Water	43-48	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	106-109
6283528-1	1982	C-peptide, which contains the 13 NH2-terminal residues of RNase A, shows partial helix formation in water at low temperature (1 degree C, pH 5, 0.1 M NaCl), as judged by CD spectra; the helix is formed intramolecularly [Brown, J. E. &amp; Klee, W. A.	Water	100-105	ribonuclease A family member 1, pancreatic	Homo sapiens	58-65
33819812-5	2021	We found that NP1 treatment protected CCI mice from injury induced learning and memory deficits observed in the Morris water maze (MWM) test at 1-month post-CCI.	Water	119-124	neuronal pentraxin 1	Mus musculus	14-17
33764781-0	2021	Different Chemical Environments of [Ge4Se10]4- in the Li+ Compounds [Li4(H2O)16][Ge4Se10] 4.33H2O, [{Li4(thf)12}Ge4Se10], and [Li2(H2O)8][MnGe4Se10], and Ionic Conductivity of Underlying "Li4Ge4Se10".	Water	94-97	lipase family member N	Homo sapiens	69-72
33764781-1	2021	The crystalline selenido germanates [Li4(H2O)16][Ge4Se10] 4.3H2O (1), [{Li4(thf)12}Ge4Se10] (2), and [Li2(H2O)8][MnGe4Se10] (3) (thf = THF = tetrahydrofuran) were obtained by an extraction of a glassy ternary phase of the nominal composition Li4Ge4Se10 (=Li2S 2GeSe2) with water (1) or THF (2) and slow evaporation of the solvent or by being layered with MnBr2 in H2O/MeOH (3), respectively.	Water	61-64	lipase family member N	Homo sapiens	37-40
33764781-1	2021	The crystalline selenido germanates [Li4(H2O)16][Ge4Se10] 4.3H2O (1), [{Li4(thf)12}Ge4Se10] (2), and [Li2(H2O)8][MnGe4Se10] (3) (thf = THF = tetrahydrofuran) were obtained by an extraction of a glassy ternary phase of the nominal composition Li4Ge4Se10 (=Li2S 2GeSe2) with water (1) or THF (2) and slow evaporation of the solvent or by being layered with MnBr2 in H2O/MeOH (3), respectively.	Water	61-64	lipase family member N	Homo sapiens	37-40
33034096-4	2021	With COD greater than 300 mg/L, the anammox process was inhibited, TN efficiency was the lowest, and effluent water quality did not yield effluent standards.	Water	110-115	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	5-8
33790391-9	2021	Finally, we compare our results with those of a FLEWS constructed directly from water level data and find that FLEWS via PH creates fewer false alarms than the conventional technique.	Water	80-85	phenylalanine hydroxylase	Homo sapiens	121-123
33806807-3	2021	In this study, we described the synthesis, structural characterization, photophysical properties and neuron cell toxicity of two new water soluble beta-CD/Cur nanoconjugates as new strategy for reducing risks of neurodegenerative diseases.	Water	133-138	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	147-154
33808830-1	2021	Water quality parameters such as salt content and various pH environments can alter the stability of gels as well as their rheological properties.	Water	0-5	phenylalanine hydroxylase	Homo sapiens	58-60
33588715-8	2021	While the human PSAT1 shows a water molecule at this site with different interacting residues, suggesting the inability of halide binding in the human enzyme.	Water	30-35	phosphoserine aminotransferase 1	Homo sapiens	16-21
33034330-9	2020	Pond water occasionally contained natural estrogens in concentrations up to 8.6 ng L-1 for E2alpha.	Water	5-10	transcription factor 3	Homo sapiens	91-98
33793233-6	2021	Moreover, the four new water models showed comparable performance or considerable improvement over the previous water models (TIP3P, SPC/E, and TIP4PEW) in the same category (3-point or 4-point water models, respectively).	Water	23-28	urocortin 3	Homo sapiens	133-136
33811391-7	2021	Cryo-SEM showed that, unlike the placebo formulation, the Trio formulation prevented the water loss when applied before the dehydration process.	Water	89-94	trio Rho guanine nucleotide exchange factor	Homo sapiens	58-62
17440595-6	2007	The linear regression analysis indicated that expression of AQP4 and its mRNA in cervical cord had a negative correlation with the change of spinal water content (r=-0.769, P&lt;0.01; r=-0.955, P&lt;0.01).	Water	148-153	aquaporin-4	Oryctolagus cuniculus	60-64
33762347-1	2021	Polymer electrolyte membrane unitized regenerative fuel cells (PEM-URFCs) require bifunctional porous transport layers (PTLs) to play contradictory roles in a single unitized system: hydrophobicity for water drainage in the fuel cell (FC) mode and hydrophilicity for water supplement in the electrolysis cell (EC) mode.	Water	202-207	mucin 1, cell surface associated	Homo sapiens	63-66
33762347-1	2021	Polymer electrolyte membrane unitized regenerative fuel cells (PEM-URFCs) require bifunctional porous transport layers (PTLs) to play contradictory roles in a single unitized system: hydrophobicity for water drainage in the fuel cell (FC) mode and hydrophilicity for water supplement in the electrolysis cell (EC) mode.	Water	267-272	mucin 1, cell surface associated	Homo sapiens	63-66
33815647-3	2020	Results obtained by flowing hydrocarbons (CH4 and CH3CHCH2) unequivocally show that these gases react with surface hydroxyl groups to produce water without producing carbon oxides and release electrons that localize on Sn to eventually form SnO.	Water	142-147	strawberry notch homolog 1	Homo sapiens	241-244
8559782-3	1995	Injection of 53 nM dopamine or the D2 dopamine receptor agonist PPHT caused a reduction of water and food intake, while the injection of the D1 receptor agonist SKF38393 had no effect.	Water	91-96	dopamine receptor D2	Rattus norvegicus	35-55
17431195-0	2007	A candidate hypertension gene: will SPON1 hold salt and water?	Water	56-61	spondin 1	Homo sapiens	36-41
34890942-4	2022	In this study, cloud point extraction (CPE) and Single Particle-Inductively Coupled Plasma-Mass Spectrometry (SP-ICP-MS) were used in combination to establish a simple and reliable analysis method to quantify Ag2S-NPs in water, with the morphology unchanged.	Water	221-226	angiotensin II receptor type 1	Homo sapiens	209-213
17351392-2	2007	The inhibition of AMPK induced growth arrest and reduction of cell viability in the cell viability assay using the water-soluble tetrazolium salt 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST-1 assay).	Water	115-120	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	18-22
34592293-7	2022	This review provides a risk assessment of EEs and identifies essential clues that will aid in formulating and revising the relevant standards of surface water regarding EEs, which is significant for ecosystems and human health.	Water	153-158	activation induced cytidine deaminase	Homo sapiens	87-90
34597567-6	2022	Moreover, a comprehensive scenario for the situations in countries like, China, Canada, Mexico, United States, Yemen, Pakistan, Saudi Arabia, South Korea, Sri Lanka, Indonesia, Iran, Turkey, Australia, and India affected with high fluoride levels in ground water has been described.	Water	257-262	sorcin	Meleagris gallopavo	155-158
17674800-10	2007	The results suggest SM can regulate the activity of AQP-1 to improve the water metabolism of ALI.	Water	73-78	aquaporin 1	Rattus norvegicus	52-57
34844343-6	2022	The first step is the hydrolysis of S1 *PYM at CN upon reaction with 2-3 water molecules (one H2O molecule as the catalyst).	Water	73-78	PYM homolog 1, exon junction complex associated factor	Homo sapiens	40-43
34844343-6	2022	The first step is the hydrolysis of S1 *PYM at CN upon reaction with 2-3 water molecules (one H2O molecule as the catalyst).	Water	94-97	PYM homolog 1, exon junction complex associated factor	Homo sapiens	40-43
17256929-3	2007	In the presence of the triaza ligand:Zn2+ complex, the change from water to methanol and then to ethanol brings about a mechanism where two molecules of the complex, suggested as EtOH:Zn2+:[12]aneN3 and its basic form, EtO-:Zn2+:[12]aneN3, bind to HPNPP and catalyze its decomposition with a rate constant of kcat of 0.13 s(-1) at s(s)pH 7.1.	Water	67-72	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	179-182
34648782-2	2022	The relationships of TOX with water quality parameters (especially the most regulated DBPs, trihalomethanes (THMs)) were also evaluated.	Water	30-35	thymocyte selection associated high mobility group box	Homo sapiens	21-24
34648782-3	2022	The TOX levels ranged between 2.6 and 70.3 mug Cl/L and between 46.6 and 205.9 mug Cl/L in raw water and distribution water, respectively.	Water	95-100	thymocyte selection associated high mobility group box	Homo sapiens	4-7
34648782-3	2022	The TOX levels ranged between 2.6 and 70.3 mug Cl/L and between 46.6 and 205.9 mug Cl/L in raw water and distribution water, respectively.	Water	118-123	thymocyte selection associated high mobility group box	Homo sapiens	4-7
17633275-8	2007	CONCLUSIONS: AQP1 in the ES may play an important role in absorbing water and regulate the balance of fluid and ion in the inner ear.	Water	68-73	aquaporin 1	Mus musculus	13-17
34648782-4	2022	The TOX concentration in water increased by an average of nine times after water treatment and varied slightly during distribution, suggesting that TOX in drinking water was mainly formed during chlorination disinfection rather than distribution.	Water	25-30	thymocyte selection associated high mobility group box	Homo sapiens	4-7
34648782-4	2022	The TOX concentration in water increased by an average of nine times after water treatment and varied slightly during distribution, suggesting that TOX in drinking water was mainly formed during chlorination disinfection rather than distribution.	Water	25-30	thymocyte selection associated high mobility group box	Homo sapiens	148-151
34648782-4	2022	The TOX concentration in water increased by an average of nine times after water treatment and varied slightly during distribution, suggesting that TOX in drinking water was mainly formed during chlorination disinfection rather than distribution.	Water	75-80	thymocyte selection associated high mobility group box	Homo sapiens	4-7
34648782-4	2022	The TOX concentration in water increased by an average of nine times after water treatment and varied slightly during distribution, suggesting that TOX in drinking water was mainly formed during chlorination disinfection rather than distribution.	Water	75-80	thymocyte selection associated high mobility group box	Homo sapiens	148-151
34648782-4	2022	The TOX concentration in water increased by an average of nine times after water treatment and varied slightly during distribution, suggesting that TOX in drinking water was mainly formed during chlorination disinfection rather than distribution.	Water	164-169	thymocyte selection associated high mobility group box	Homo sapiens	4-7
17243701-0	2007	Tyrosinase-aided protein cross-linking: effects on gel formation of chicken breast myofibrils and texture and water-holding of chicken breast meat homogenate gels.	Water	110-115	tyrosinase	Gallus gallus	0-10
17243701-2	2007	In addition, tyrosinase-catalyzed cross-linking was utilized to modify the firmness, water-holding capacity (WHC), and microstructure of cooked chicken breast meat homogenate gels.	Water	85-90	tyrosinase	Gallus gallus	13-23
17207845-0	2007	Co-variations of bacterial composition and catabolic genes related to PAH degradation in a produced water treatment system consisting of successive anoxic and aerobic units.	Water	100-105	phenylalanine hydroxylase	Homo sapiens	70-73
34799950-7	2022	In addition, 3SEB inherently partitions water fluxes between the tree, grass and soil sources.	Water	40-45	SET binding protein 1	Homo sapiens	14-17
34806833-0	2022	Electrified conversion of contaminated water to value: selective conversion of aqueous nitrate to ammonia in a PEM cell.	Water	39-44	mucin 1, cell surface associated	Homo sapiens	111-114
17287564-4	2007	Mean-while, water loss results in increased activities of reactive-oxygen-scavenging enzymes (SOD, CAT, APX and GR).	Water	12-17	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	104-107
34806833-1	2022	The application of a polymer electrolyte membrane (PEM) electrolytic cell for continuous conversion of nitrate, one of the contaminants in water, to ammonia at the cathode was explored in the present work.	Water	139-144	mucin 1, cell surface associated	Homo sapiens	51-54
17694799-1	2007	Brain natriuretic peptide (BNP) is one of the cardiac peptide hormones that are involved in water and electrolyte homeostasis in heart failure.	Water	92-97	natriuretic peptide B	Homo sapiens	0-25
34391969-4	2022	Under the synergy of PMIA, PAN and SiO2, the composite membrane possesses high PM0.3 removal capacity of 99.69%, robust purification ability against real smoke PM2.5, effective oil/water separation performance of > 99.6%, superior high temperature stability (about 250  C) and excellent chemical resistance, showing the potential application in filtration/separation process under complex conditions.	Water	181-186	adenosine deaminase 2	Homo sapiens	27-30
17694799-1	2007	Brain natriuretic peptide (BNP) is one of the cardiac peptide hormones that are involved in water and electrolyte homeostasis in heart failure.	Water	92-97	natriuretic peptide B	Homo sapiens	27-30
17661322-3	2007	[VO3]- dehydrated methanol to eliminate water and form [VO2(eta2-OCH2)]-, which features an [eta2-C,O-OCH2]2- ligand formed by formal removal of two protons from methanol and which is isoelectronic with peroxide.	Water	40-45	DNA polymerase iota	Homo sapiens	60-64
34742416-2	2022	Chitosan (CS) hydrogels are high water content materials with very relevant biological properties to that purpose.	Water	33-38	citrate synthase	Homo sapiens	10-12
34424476-8	2022	According to the Dillon model, when the target water quality was level III (GB 3838-2002, Ministry of Environmental Protection of China, 2002), the remaining TN and TP loading capacities were -1470.72 t/a and -182.74 t/a, respectively, in 2015, and 320.03 t/a and -111.14 t/a, respectively, in 2018.	Water	47-52	C-type lectin domain family 3 member B	Homo sapiens	158-160
17661322-3	2007	[VO3]- dehydrated methanol to eliminate water and form [VO2(eta2-OCH2)]-, which features an [eta2-C,O-OCH2]2- ligand formed by formal removal of two protons from methanol and which is isoelectronic with peroxide.	Water	40-45	DNA polymerase iota	Homo sapiens	93-97
17661322-7	2007	The latter reacted further to eliminate water and generate the product [VO2(eta2-OCHR)]-.	Water	40-45	DNA polymerase iota	Homo sapiens	76-80
16855541-6	2007	RESULTS: Fat-free mass increased when the 10 subjects were carrying water.	Water	68-73	FAT atypical cadherin 1	Homo sapiens	9-12
34927252-7	2021	The water absorption rate and the maximum compression stress of the hydrogels were affected by the chitosan molecular weight and show the descending sequence of LCS, HCS, MCS and HCS, MCS, LCS, respectively.	Water	4-9	holocarboxylase synthetase	Homo sapiens	179-182
16855541-9	2007	Mixed loads (+1 l oil and 1 l water) led to detect +0.85+/-0.48 kg fat and +1.09+/-0.45 kg fat-free (both P&lt;0.005 vs without load).	Water	30-35	FAT atypical cadherin 1	Homo sapiens	67-70
16855541-9	2007	Mixed loads (+1 l oil and 1 l water) led to detect +0.85+/-0.48 kg fat and +1.09+/-0.45 kg fat-free (both P&lt;0.005 vs without load).	Water	30-35	FAT atypical cadherin 1	Homo sapiens	91-94
34961219-5	2021	Compared with the water control treatment, the combined ABA + CaCl2 treatment significantly improved the superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) of the seedlings by 34.47%, 59.66%, and 118.80%, respectively (p < 0.05), and significantly reduced the chilling injury index, relative electrical conductivity, and MDA content, by 89.47%, 62.17%, and 44.55%, respectively (p < 0.05).	Water	18-23	L-ascorbate peroxidase, cytosolic-like	Cucumis sativus	153-173
16797007-1	2007	Aldehyde dehydrogenase 3A1 (ALDH3A1) comprises a surprisingly high proportion (5-50% depending on species) of the water-soluble protein of the mammalian cornea, but is present little if at all in the cornea of other species.	Water	114-119	aldehyde dehydrogenase 3 family member A1	Homo sapiens	0-26
34961219-5	2021	Compared with the water control treatment, the combined ABA + CaCl2 treatment significantly improved the superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) of the seedlings by 34.47%, 59.66%, and 118.80%, respectively (p < 0.05), and significantly reduced the chilling injury index, relative electrical conductivity, and MDA content, by 89.47%, 62.17%, and 44.55%, respectively (p < 0.05).	Water	18-23	L-ascorbate peroxidase, cytosolic-like	Cucumis sativus	175-178
34947202-0	2021	Produced Water Treatment with Conventional Adsorbents and MOF as an Alternative: A Review.	Water	9-14	lysine acetyltransferase 8	Homo sapiens	58-61
34947202-11	2021	Moreover, it is concluded that there is a need to develop highly porous, efficient, eco-friendly, cost-effective, mechanically stable, and sustainable MOF hybrids for produced water treatment.	Water	176-181	lysine acetyltransferase 8	Homo sapiens	151-154
16797007-1	2007	Aldehyde dehydrogenase 3A1 (ALDH3A1) comprises a surprisingly high proportion (5-50% depending on species) of the water-soluble protein of the mammalian cornea, but is present little if at all in the cornea of other species.	Water	114-119	aldehyde dehydrogenase 3 family member A1	Homo sapiens	28-35
17869641-7	2007	Serum deprivation (0.5% FBS) producing ROS and exogenous H(2)O(2) treatment also enhanced mBAFF promoter activity, which was reduced by N-acetyl-l-cysteine (NAC), a well-known ROS scavenger.	Water	57-62	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	90-95
17954255-4	2007	The lipid phosphate phosphatase activities of DPP1-encoded and LPP1-encoded enzymes are measured by following the release of water-soluble radioactive inorganic phosphate from chloroform-soluble radioactive lipid phosphate substrate following a chloroform/methanol/water phase partition.	Water	125-130	phosphatidate phosphatase LPP1	Saccharomyces cerevisiae S288C	63-67
34463769-7	2021	We propose that accelerated retinal release confers rapid rhodopsin recharging, enabling the visual systems of diving species to adjust quickly to changing light levels as they descend through the water column.	Water	197-202	rhodopsin	Aptenodytes forsteri	58-67
34885615-2	2021	To explore the application of CFB slag in cement-stabilized bases, this paper studies the influence of different dosage of CFBS on the mechanics, water stability, and shrinkage of cement-stabilized soil using laboratory experiments.	Water	146-151	complement factor B	Homo sapiens	30-33
17954255-4	2007	The lipid phosphate phosphatase activities of DPP1-encoded and LPP1-encoded enzymes are measured by following the release of water-soluble radioactive inorganic phosphate from chloroform-soluble radioactive lipid phosphate substrate following a chloroform/methanol/water phase partition.	Water	265-270	phosphatidate phosphatase LPP1	Saccharomyces cerevisiae S288C	63-67
17325980-2	2007	Physiologically regulated epithelial ion and water transport coordinated with mucin secretion, beating cilia, and cough results in continuous flow of fluid and mucus over airway surfaces toward the larynx.	Water	45-50	LOC100508689	Homo sapiens	78-83
34940306-6	2021	Mixing CS with CNFs significantly enhance the mechanical properties and reduce its water uptake.	Water	83-88	citrate synthase	Homo sapiens	7-9
17546976-5	2007	Water from a Tannery company in Lichtenvoorde in the Netherlands, The Hulshof Royal Dutch Tanneries, was pretreated anaerobically for COD removal and aerobically to remove the sulphides as sulphur.	Water	0-5	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	134-137
34186221-4	2021	The pure water flux of the PGA-3 membrane (254 LMH) was increased to more than 2-fold compared to that of the neat PVDF membrane (126 LMH).	Water	9-14	pepsinogen A3	Homo sapiens	27-32
34186221-6	2021	Finally, after conducting multi-cycle filtration experiments with lake water, the flux and recovery rate of the PGA-3 membrane was observed to be the highest, and the water quality of the lake water filtered by the PGA-3 membrane was the best.	Water	71-76	pepsinogen A3	Homo sapiens	112-117
34186221-6	2021	Finally, after conducting multi-cycle filtration experiments with lake water, the flux and recovery rate of the PGA-3 membrane was observed to be the highest, and the water quality of the lake water filtered by the PGA-3 membrane was the best.	Water	71-76	pepsinogen A3	Homo sapiens	215-220
34186221-6	2021	Finally, after conducting multi-cycle filtration experiments with lake water, the flux and recovery rate of the PGA-3 membrane was observed to be the highest, and the water quality of the lake water filtered by the PGA-3 membrane was the best.	Water	167-172	pepsinogen A3	Homo sapiens	215-220
34186221-6	2021	Finally, after conducting multi-cycle filtration experiments with lake water, the flux and recovery rate of the PGA-3 membrane was observed to be the highest, and the water quality of the lake water filtered by the PGA-3 membrane was the best.	Water	193-198	pepsinogen A3	Homo sapiens	215-220
33807529-7	2021	The functionalization of CS film with hydroxycinnamic acids produced a more compact microstructure and higher UV light barrier ability, mechanical strength, water vapor barrier ability, thermal stability and antioxidant and antimicrobial activities.	Water	157-162	citrate synthase	Homo sapiens	25-27
33776618-4	2021	Objective: We investigated the effects of water extract from AAL on high-fat-diet (HFD)-induced obese mice and 3T3-L1 adipocytes to develop a new functional food material.	Water	42-47	active avoidance learning	Mus musculus	61-64
33776618-16	2021	Conclusion: AAL water-soluble extract has a significant anti-adipogenic effect in the HFD-induced obese mice model.	Water	16-21	active avoidance learning	Mus musculus	12-15
17674820-3	2007	It has been demonstrated that electrons with this energy can dissociate water and oxygen molecules and produce various reactive radicals (*OH, H*, O*, HO2*), molecular species (H2O2, H2, O2), ultraviolet radiation and shock waves.	Water	72-77	heme oxygenase 2	Homo sapiens	151-154
34198066-5	2021	MOF showed excellent dye removal and degradation capacity owing to its multifunctionality, water-stability, large surface area, tunable pore size and recyclability.	Water	91-96	lysine acetyltransferase 8	Homo sapiens	0-3
17192176-14	2006	The ice water test may be a useful and simple marker for clinical trials in PBS, particularly for novel selective TRPM8 antagonists.	Water	8-13	transient receptor potential cation channel subfamily M member 8	Homo sapiens	114-119
34880650-2	2021	While there are nine isoforms of NHE in humans, this review focuses on the NHE3 isoform, which is abundantly expressed in the gastrointestinal tract, where it plays a key role in acid-base balance and water homeostasis.	Water	201-206	solute carrier family 9 member C1	Homo sapiens	33-36
32083456-8	2020	The 2D-SCN-3h indicated higher efficiency in photogenerated charge carrier separation and showed the highest reductive activity in photocatalytic splitting of water at a rate of 127.4 mumol/h under simulated solar light irradiation, which was 250 times and 3 times higher than that of SCN and 2D-CN photocatalysts, respectively.	Water	159-164	HCLS1 associated protein X-1	Homo sapiens	7-12
17184504-16	2006	In the control group, the stimulatory effect of leptin was abolished by the NADPH oxidase inhibitor apocynin (1 micromol/min per kg), the H(2)O(2) scavenger catalase (1 mg/min per kg) and the extracellular signal-regulated kinase (ERK) inhibitor PD98059 (100 nmol/min per kg).	Water	138-143	leptin	Rattus norvegicus	48-54
34902672-4	2022	The obtained Lac-ATA-CPT2 prodrug and the photosensitizer Chlorin e6 (Ce6) formed CF SNPD (denoted as Ce6@Lac-ATA-CPT2 NPs) in water by supramolecular self-assembly.	Water	127-132	carnitine palmitoyltransferase 2	Homo sapiens	21-25
34902672-4	2022	The obtained Lac-ATA-CPT2 prodrug and the photosensitizer Chlorin e6 (Ce6) formed CF SNPD (denoted as Ce6@Lac-ATA-CPT2 NPs) in water by supramolecular self-assembly.	Water	127-132	carnitine palmitoyltransferase 2	Homo sapiens	114-118
34717959-5	2021	Arginine insertion into membrane proteins can generate water-filled pores in the plasma membrane, and our molecular dynamic (MD) simulations of the principle states of Na+,K+-ATPase transport demonstrated massive water inflow into mutant alpha1, and destabilization of the ion binding sites.	Water	55-60	ATPase H+ transporting V0 subunit a1	Homo sapiens	238-244
34717959-5	2021	Arginine insertion into membrane proteins can generate water-filled pores in the plasma membrane, and our molecular dynamic (MD) simulations of the principle states of Na+,K+-ATPase transport demonstrated massive water inflow into mutant alpha1, and destabilization of the ion binding sites.	Water	213-218	ATPase H+ transporting V0 subunit a1	Homo sapiens	238-244
17089010-0	2006	Comano"s (Trentino) thermal water interferes with interleukin-6 production and secretion and with cytokeratin-16 expression by cultured human psoriatic keratinocytes: further potential mechanisms of its anti-psoriatic action.	Water	28-33	keratin 16	Homo sapiens	98-112
34906576-5	2022	In particular, the water levels of PX-2 were abnormally low compared with the surrounding area.	Water	19-24	pannexin 2	Homo sapiens	35-39
34906576-9	2022	Accordingly, it is important that PX-2 is continuously monitored until June 2024, the minimum period predicted for the water levels to reach stability.	Water	119-124	pannexin 2	Homo sapiens	34-38
34689089-6	2022	For instance, the adsorption efficiency of Cr3+ and Cr6+ is found to be 42.02% and 5.79% respectively using microcellulose, while nanocellulose adsorbed 62.40% of Cr3+ ions and 5.98% of Cr6+ ions from contaminated water.	Water	214-219	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	43-46
34689089-6	2022	For instance, the adsorption efficiency of Cr3+ and Cr6+ is found to be 42.02% and 5.79% respectively using microcellulose, while nanocellulose adsorbed 62.40% of Cr3+ ions and 5.98% of Cr6+ ions from contaminated water.	Water	214-219	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	163-166
17081248-10	2006	In particular, in the resistant genotypes the expression of DHN genes is initiated even though tissue hydration levels are still high, indicating also in wheat the involvement of these proteins in water retention.	Water	197-202	dehydrin Rab25	Triticum aestivum	60-63
34479086-0	2022	Accurate prediction and further dissection of neonicotinoid elimination in the water treatment by CTS@AgBC using multihead attention-based convolutional neural network combined with the time-dependent Cox regression model.	Water	79-84	cytochrome c oxidase subunit 8A	Homo sapiens	201-204
17026966-5	2006	The resulting double-mutant (Ttpa-/- APPsw) mice showed earlier and more severe cognitive dysfunction in the Morris water maze, novel-object recognition, and contextual fear conditioning tests.	Water	116-121	tocopherol (alpha) transfer protein	Mus musculus	29-33
34699768-0	2022	The role of water coordination in the pH-dependent gating of hAQP10.	Water	12-17	aquaporin 10	Homo sapiens	61-67
34648782-4	2022	The TOX concentration in water increased by an average of nine times after water treatment and varied slightly during distribution, suggesting that TOX in drinking water was mainly formed during chlorination disinfection rather than distribution.	Water	164-169	thymocyte selection associated high mobility group box	Homo sapiens	148-151
34648782-6	2022	Positive correlations were found between raw water dissolved organic carbon (DOC) with an increase in TOX in treated water and between DOC level with TOX content in distributed water, emphasizing a key role of organics in TOX formation.	Water	45-50	thymocyte selection associated high mobility group box	Homo sapiens	102-105
34648782-6	2022	Positive correlations were found between raw water dissolved organic carbon (DOC) with an increase in TOX in treated water and between DOC level with TOX content in distributed water, emphasizing a key role of organics in TOX formation.	Water	45-50	thymocyte selection associated high mobility group box	Homo sapiens	222-225
34648782-6	2022	Positive correlations were found between raw water dissolved organic carbon (DOC) with an increase in TOX in treated water and between DOC level with TOX content in distributed water, emphasizing a key role of organics in TOX formation.	Water	117-122	thymocyte selection associated high mobility group box	Homo sapiens	102-105
17096537-5	2006	The intrinsic viscosity, [eta], of the polysaccharide in Milli-Q water was 1030 +/- 20 mL/g.	Water	65-70	endothelin receptor type A	Homo sapiens	26-29
34648782-6	2022	Positive correlations were found between raw water dissolved organic carbon (DOC) with an increase in TOX in treated water and between DOC level with TOX content in distributed water, emphasizing a key role of organics in TOX formation.	Water	117-122	thymocyte selection associated high mobility group box	Homo sapiens	222-225
34648782-6	2022	Positive correlations were found between raw water dissolved organic carbon (DOC) with an increase in TOX in treated water and between DOC level with TOX content in distributed water, emphasizing a key role of organics in TOX formation.	Water	177-182	thymocyte selection associated high mobility group box	Homo sapiens	150-153
34648782-6	2022	Positive correlations were found between raw water dissolved organic carbon (DOC) with an increase in TOX in treated water and between DOC level with TOX content in distributed water, emphasizing a key role of organics in TOX formation.	Water	177-182	thymocyte selection associated high mobility group box	Homo sapiens	222-225
17047754-0	2006	The relaxation of OH (v=1) and OD (v=1) by H2O and D2O at temperatures from 251 to 390 K. We report rate coefficients for the relaxation of OH(v=1) and OD(v=1) by H2O and D2O as a function of temperature between 251 and 390 K. All four rate coefficients exhibit a negative dependence on temperature.	Water	43-46	immunoglobulin kappa variable 1-5	Homo sapiens	35-38
34595702-6	2022	The uncertainty for water quality caused by roughness presented a striking spatial difference; the uncertainty interval for TN could be up to 1.3 mg/L.	Water	20-25	C-type lectin domain family 3 member B	Homo sapiens	124-126
16823521-0	2006	Male-biased sex ratios and vitellogenin induction in zebrafish exposed to effluent water from a Swedish pulp mill.	Water	83-88	vitellogenin	Danio rerio	27-39
34844312-3	2022	The occurrence of PMMA-NPLs in aquatic ecosystems may thus cause adverse effects particularly to early life stages of amphibians, which may be in contact with PMMA-NPLs suspended in the water column or deposited in upper layers of the sediments.	Water	186-191	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) S homeolog	Xenopus laevis	23-27
34844312-3	2022	The occurrence of PMMA-NPLs in aquatic ecosystems may thus cause adverse effects particularly to early life stages of amphibians, which may be in contact with PMMA-NPLs suspended in the water column or deposited in upper layers of the sediments.	Water	186-191	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) S homeolog	Xenopus laevis	164-168
16784862-2	2006	The problems of limited water solubility and high melting points commonly displayed by the active 1,3-disubstituted ureas prevent the further development of potent urea-based sEH inhibitors.	Water	24-29	epoxide hydrolase 2	Homo sapiens	175-178
34213342-0	2022	Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3beta Inhibitors.	Water	33-38	glycogen synthase kinase 3 beta	Homo sapiens	99-129
34213342-2	2022	Here, by addressing a high-energy water, we improved the IC50 value of our co-crystallized glycogen synthase kinase-3beta (GSK-3beta) inhibitor by nearly two orders of magnitude.	Water	34-39	glycogen synthase kinase 3 beta	Homo sapiens	91-121
16784862-3	2006	Therefore, a new class of potent inhibitors of sEH were designed and synthesized by the introduction of a polar constrained piperazino group in the right side of adasmantyl urea to increase the water solubility.	Water	194-199	epoxide hydrolase 2	Homo sapiens	47-50
34213342-2	2022	Here, by addressing a high-energy water, we improved the IC50 value of our co-crystallized glycogen synthase kinase-3beta (GSK-3beta) inhibitor by nearly two orders of magnitude.	Water	34-39	glycogen synthase kinase 3 alpha	Homo sapiens	123-132
16430954-6	2006	RESULTS: Main variables determining water-solvent evaporation of the tested adhesives are: (1) water/HEMA relative concentration, (2) presence of photoinitiator compounds in the primer (SEB) and (3) presence of ethanol (XENO).	Water	36-41	SET binding protein 1	Homo sapiens	186-189
34741946-10	2022	Results showed that water supply performance without climate change adaptation is worse under climate scenarios with lower water availability, which are likely to be associated with higher GHG emission scenarios such as RCP 8.5.	Water	20-25	CGRP receptor component	Homo sapiens	220-223
34741946-10	2022	Results showed that water supply performance without climate change adaptation is worse under climate scenarios with lower water availability, which are likely to be associated with higher GHG emission scenarios such as RCP 8.5.	Water	123-128	CGRP receptor component	Homo sapiens	220-223
34492494-6	2022	Our dataset includes a large range for three key water quality parameters of TN from 0.93 to 6.46 mg/L, TP from 0.04 to 0.62 mg/L, and COD from 1.32 to 15.41 mg/L.	Water	49-54	C-type lectin domain family 3 member B	Homo sapiens	77-79
16970413-1	2006	trans-Sodium crocetinate (TSC) increases the diffusion coefficient of glucose through water by about 25-30%.	Water	86-91	solute carrier family 12 member 3	Homo sapiens	26-29
34811762-10	2022	In this study, LCA was loaded on liposome carriers, which significantly improved the water solubility and oral bioavailability, and proved that LCA-Liposomes have certain therapeutic effects on chronic renal failure, thereby providing a basis for the development of LCA into drugs or functional food in the future.	Water	85-90	clathrin, light polypeptide (Lca)	Mus musculus	15-18
16970413-2	2006	This is the same percentage increase that TSC causes in the diffusivity of oxygen through water.	Water	90-95	solute carrier family 12 member 3	Homo sapiens	42-45
16970413-3	2006	TSC is also found to induce order in the surrounding water structure through increased hydrogen bonding of the water molecules, and molecular simulations suggest that the increase in diffusivity occurs only in these ordered regions.	Water	53-58	solute carrier family 12 member 3	Homo sapiens	0-3
16970413-3	2006	TSC is also found to induce order in the surrounding water structure through increased hydrogen bonding of the water molecules, and molecular simulations suggest that the increase in diffusivity occurs only in these ordered regions.	Water	111-116	solute carrier family 12 member 3	Homo sapiens	0-3
16621088-3	2006	Secondly, lipase (PPL) was used to catalyze the formation of Bz-RGDS-NH(2) in aqueous water-miscible organic cosolvent systems using Bz-Arg-OEt as the acyl donor and GDS-NH(2) as the nucleophile.	Water	86-91	ral guanine nucleotide dissociation stimulator	Homo sapiens	64-68
34958380-0	2022	Fat-Free Mass and Total Daily Energy Expenditure Estimated using Doubly Labelled Water Predict Energy Intake in a Large Sample of Community-Dwelling Older Adults.	Water	81-86	FAT atypical cadherin 1	Homo sapiens	0-3
34911756-3	2021	O-MIF, reported as Delta"17O, is produced during the formation of ozone and destroyed by isotopic exchange with water by biological and chemical processes.	Water	112-117	macrophage migration inhibitory factor	Homo sapiens	2-5
16961363-3	2006	The extent of a structural change of the iron center from a preferred square-pyramidal to a distorted trigonal-bipyramidal geometry varies with the external ligand that is bound in the order Cl &lt;&lt; EtO &lt; H2O, which is consistent with the spectrochemical series.	Water	212-215	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	203-206
16828561-4	2006	A quinic acid-glycine-7-amino-coumarine (Quiglac) chromophore was constructed in order to enhance the solubility of labelled LI-cadherin (glyco)peptides in water.	Water	156-161	cadherin 17	Mus musculus	125-136
34923968-9	2021	RESULTS: The RT-qPCR data showed that Gdnf mRNA level in NAc was more than four times higher (p < 0.0001) in the mice from the sweetened alcohol group compared to the water group.	Water	167-172	glial cell line derived neurotrophic factor	Mus musculus	38-42
34975522-3	2021	We previously demonstrated that hypoxia upregulates the expression of aquaporin 1 (AQP1), a water channel, in PASMCs, and that this upregulation was required for hypoxia-induced migration and proliferation.	Water	92-97	aquaporin 1	Rattus norvegicus	70-81
34975522-3	2021	We previously demonstrated that hypoxia upregulates the expression of aquaporin 1 (AQP1), a water channel, in PASMCs, and that this upregulation was required for hypoxia-induced migration and proliferation.	Water	92-97	aquaporin 1	Rattus norvegicus	83-87
16842743-4	2006	Our study has revealed that an intriguing Grotthuss hopping mechanism of proton transfer involving water and three conserved aspartate residues in pol beta"s active site mediates the phosphoryl transfer in the correct as well as misincorporation of nucleotides.	Water	99-104	DNA polymerase beta	Homo sapiens	147-155
34952286-5	2022	This work provides a simple reproducible method to fabricate the water-soluble and biocompatible Ag2S NPs, which would provide new insights of designing new functional NPs for the PTT therapy of tumor.	Water	65-70	angiotensin II receptor type 1	Homo sapiens	97-101
16818469-3	2006	Transfection of B16F10 and 4T1 tumor cells with AQP1 did not affect their appearance, size, growth, or substrate adherence but increased their plasma membrane osmotic water permeability by 5- to 10-fold.	Water	167-172	aquaporin 1	Mus musculus	48-52
34537597-2	2021	In this study, an artificial neural network model (i.e., multi-layer perceptron, MLP) and a statistical inference model (i.e., stepwise-cluster analysis, SCA) are developed for predicting chloride concentration in stream water.	Water	221-226	cysteine and glycine rich protein 3	Homo sapiens	81-84
34537597-8	2021	The outstanding performance of the proposed MLP-SCA, particularly in extreme value prediction, indicates that it can provide reliable chloride prediction using commonly available data (i.e., conductivity, water temperature, river flow rate, and rainfall).	Water	205-210	cysteine and glycine rich protein 3	Homo sapiens	44-47
34537597-10	2021	MLP-SCA is the first ensemble learning model for river chloride prediction and can be extended to other river systems for water quality prediction.	Water	122-127	cysteine and glycine rich protein 3	Homo sapiens	0-3
16790434-9	2006	The reprotonation of C4" of PLP, the rate-limiting step of 15A9-catalyzed transamination, is most likely performed by a water molecule that, assisted by Lys-H96, produces a hydroxide ion stabilized by the anion-binding environment.	Water	120-125	pyridoxal phosphatase	Homo sapiens	28-31
34886821-1	2021	OBJECTIVE: To evaluate cognitive impairment and risk factors of elders in high fluoride drinking water areas and investigate whether DKK1 is involved in this disorder.	Water	97-102	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	133-137
34886821-3	2021	RESULTS: The blood fluoride concentration, mRNA level of DKK1 and ratio of abnormal cognitive function of subjects in high fluorine drinking water areas were higher than those in normal areas.	Water	141-146	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	57-61
34186388-0	2021	Defect-rich, negatively-charged SnS2 nanosheets for efficient photocatalytic Cr(VI) reduction and organic dye adsorption in water.	Water	124-129	sodium voltage-gated channel alpha subunit 11	Homo sapiens	32-36
34787135-0	2021	Enhanced electrochemical performance of Li2.72Na0.31MnPO4CO3 as a cathode material in "water-in-salt" electrolytes.	Water	87-92	ATP binding cassette subfamily A member 12	Homo sapiens	40-43
16582023-9	2006	Water permeability was reduced by AQP-1 knockout but not by AQP-4 or AQP-8 knockout.	Water	0-5	aquaporin 1	Rattus norvegicus	34-39
34849467-4	2021	Here, we demonstrate a method that produces water-dispersible Ti3C2Tz nanosheets using molten salt (SnF2) to etch.	Water	44-49	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	100-104
34813333-5	2021	These observations shed light on key stages through which CaF2 NCs are dispersed in water, highlighting fundamental aspects of nanofluorides formation mechanisms.	Water	84-89	CCR4-NOT transcription complex subunit 8	Homo sapiens	58-62
34846396-5	2021	The vertical ALMO-EDA scheme is applied to HCl-water clusters along a proton-transfer coordinate varying the amount of spectator water molecules.	Water	47-52	ectodysplasin A	Homo sapiens	18-21
34846396-5	2021	The vertical ALMO-EDA scheme is applied to HCl-water clusters along a proton-transfer coordinate varying the amount of spectator water molecules.	Water	129-134	ectodysplasin A	Homo sapiens	18-21
34846396-6	2021	The corresponding ALMO-EDA results show a clear preference for the dissociated cluster only in the presence of four water molecules.	Water	116-121	ectodysplasin A	Homo sapiens	23-26
16696965-8	2006	Measurements with the dye merocyanine 540 indicate that the water-membrane interface was affected in opposite directions by the presence of high concentrations of sucrose or Bet.	Water	60-65	delta/notch like EGF repeat containing	Homo sapiens	174-177
34807618-5	2021	We suggested a relation based on these parameters to predict the surface morphology (smoothness or roughness) of CS particles synthesized through SDP in water.	Water	153-158	citrate synthase	Homo sapiens	113-115
34917955-6	2021	SPs like SP-A and SP-D have antimicrobial activities providing a crucial first line of defense against infections in lungs whereas SP-B and SP-C are mainly involved in respiratory cycle and reduction of surface tension at air-water interface.	Water	226-231	surfactant protein B	Homo sapiens	131-135
16837191-3	2006	In particular, recently determined structures of plant SoPIP2;1, sheep and bovine AQP0, and Escherichia coli AQPZ provide new insights into the underlying structural mechanisms by which water transport rates are regulated in diverse organisms.	Water	186-191	major intrinsic protein of lens fiber	Bos taurus	82-86
34855169-4	2022	The typical spatiality in poverty and livelihood vulnerability is triggered by the fragility of fishing livelihoods in the wake of lower concentrations of dissolved oxygen (DO), and higher BOD, COD, ammonia, nitrate and phosphate mainly due to industrial water pollution.	Water	255-260	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	194-197
34161865-3	2021	However, due to low water solubility, poor pharmacokinetic properties and low therapeutic effects are the major obstacle, and had significantly limited its clinical application.	Water	20-25	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	126-129
16871588-7	2006	Inhibition of p38 and NF-kappaB activation by SB203580 and pyrrolidine dithiocarbamate, respectively, blocked endotoxin-induced H(2)O(2), NO, TNF-alpha, and IL-6 synthesis.	Water	128-133	mitogen activated protein kinase 14	Rattus norvegicus	14-17
34827886-3	2021	The alien species occurrences correlated positively (p < 0.05) with poor water quality, such as rivers with high ammonia-nitrogen and nitrite, but negatively with phosphate and dissolved oxygen.	Water	73-78	COP9 signalosome subunit 2	Homo sapiens	4-9
34771065-4	2021	The data obtained indicate that the chemical composition of the water in the Rasa River estuary primarily reflects the high input of suspended sediment from the catchment, the mixing of freshwater and seawater, and to a lesser extent the effects of anthropogenic activities.	Water	64-69	RAS p21 protein activator 1	Homo sapiens	77-81
34783528-7	2021	Meanwhile, the low overpotential of multifunctional photocatalysts of the Bi@beta-Sb monolayer makes them show a remarkable performance in overall water splitting (0.06 V for HER, 0.25 V for OER, and 0.31 V for ORR).	Water	147-152	5'-aminolevulinate synthase 2	Homo sapiens	77-84
16798945-0	2006	Enhancement of abscisic acid sensitivity and reduction of water consumption in Arabidopsis by combined inactivation of the protein phosphatases type 2C ABI1 and HAB1.	Water	58-63	Protein phosphatase 2C family protein	Arabidopsis thaliana	152-156
34528858-14	2021	By regulating AQP1 and AQP2, both water retention and toxin accumulation were reduced.	Water	34-39	aquaporin 1	Rattus norvegicus	14-18
34853925-8	2021	Results suggest that HI significantly reduced FAM3A expression in rat brain tissues, and that overexpression of FAM3A through lentiviral transduction effectively improved cognitive and motor functions in HI rats as reflected by improved NSS evaluation, cerebral water content, limb strength, as well as spatial learning and memory.	Water	262-267	FAM3 metabolism regulating signaling molecule A	Rattus norvegicus	112-117
34771065-7	2021	The obtained depth profiles of the oxyanion distribution in the sediment pore water indicate an early onset of suboxic to anoxic conditions in Rasa Bay, which is prone to rapid sedimentation.	Water	78-83	RAS p21 protein activator 1	Homo sapiens	143-147
34612241-1	2021	Reaction of (LiPb(OiPr)3)2 (generated in situ) with either p-tert-butylcalix(4)areneH4 (L4H4) or p-tert-butylcalix(6)areneH6 (L6H6) resulted in the heterometallic lithium/lead complexes (Pb4Li2(L4)4H6(MeCN)3) 4.5MeCN (1 4.5MeCN) and (Pb8Li10Cl2(L6H2)3(L6)(OH)2(O)2(H2O)2(MeCN)4) 14MeCN (2 14MeCN), respectively.	Water	265-268	lipase B, lysosomal acid type	Homo sapiens	13-17
16798945-0	2006	Enhancement of abscisic acid sensitivity and reduction of water consumption in Arabidopsis by combined inactivation of the protein phosphatases type 2C ABI1 and HAB1.	Water	58-63	HYPERSENSITIVE TO ABA1	Arabidopsis thaliana	161-165
16870726-1	2006	Aquaporins are known as water channels; however, an additional ion channel function has been observed for several including aquaporin-1 (AQP1).	Water	24-29	aquaporin 1	Rattus norvegicus	124-135
34669384-5	2021	Both 4NC and 24NDP had much lower photolysis rates in water than in organic matrices, suggesting that they would photolyze more efficiently in organic aerosol particles than in cloud or fog droplets.	Water	54-59	norrin cystine knot growth factor NDP	Homo sapiens	15-18
34217932-3	2021	This work evaluates the role of different extraction methods (agitation, sonication at sediment pH, and sonication at alkaline pH) on the characteristics (mass, size, shape and composition) of water-mobilizable colloids from sediment of Champsanglard dam reservoir (France).	Water	193-198	phenylalanine hydroxylase	Homo sapiens	96-98
34217932-3	2021	This work evaluates the role of different extraction methods (agitation, sonication at sediment pH, and sonication at alkaline pH) on the characteristics (mass, size, shape and composition) of water-mobilizable colloids from sediment of Champsanglard dam reservoir (France).	Water	193-198	phenylalanine hydroxylase	Homo sapiens	127-129
34492601-1	2021	Casein hydrolysate (Pep) is a dispersant for poorly water-soluble drugs and nutraceutical ingredients.	Water	52-57	prolyl endopeptidase	Homo sapiens	20-23
34492601-2	2021	However, two types of complexes may be between Pep and poorly water-soluble molecules: those that are (1) dispersed as hydrocolloids in aqueous media with a particle size of 100-500 nm; and (2) not hydrocolloids, as indicated by permeability of the complex through an ultrafiltration (UF) membrane and the fact that the particle size is ambiguous by dynamic light scattering.	Water	62-67	prolyl endopeptidase	Homo sapiens	47-50
16870726-1	2006	Aquaporins are known as water channels; however, an additional ion channel function has been observed for several including aquaporin-1 (AQP1).	Water	24-29	aquaporin 1	Rattus norvegicus	137-141
34492601-4	2021	We classified the dissolution state of the complexes between poorly water-soluble ingredients and Pep by the permeability using a UF membrane.	Water	68-73	prolyl endopeptidase	Homo sapiens	98-101
34492601-7	2021	Furthermore, we determined the stoichiometry and association constant for the complex between a major peptide in Pep and poorly water-soluble resveratrol (Res) based on fluorescence quenching.	Water	128-133	prolyl endopeptidase	Homo sapiens	113-116
34728720-0	2021	A 400-Gb/s WDM-PAM4 OWC system through the free-space transmission with a water-air-water link.	Water	74-79	WDM	Homo sapiens	11-14
34728720-0	2021	A 400-Gb/s WDM-PAM4 OWC system through the free-space transmission with a water-air-water link.	Water	84-89	WDM	Homo sapiens	11-14
16870726-8	2006	These results confirm that AQP1 can function as both a water channel and a gated ion channel.	Water	55-60	aquaporin 1	Rattus norvegicus	27-31
16910777-4	2006	The rate of aminotriazole-inhibited catalase activity also was increased when SOD2 is overexpressed and reflects a 1.6-fold increase in the steady-state production of H(2)O(2).	Water	167-172	superoxide dismutase 2	Homo sapiens	78-82
34728720-1	2021	A 400-Gb/s wavelength-division-multiplexing (WDM) four-level pulse amplitude modulation (PAM4) optical wireless communication (OWC) system through a 200-m free-space transmission with either an 8.8-m piped water-air-piped water link or a 6.5-m turbid water-air-turbid water link is successfully constructed.	Water	206-211	WDM	Homo sapiens	45-48
34728720-1	2021	A 400-Gb/s wavelength-division-multiplexing (WDM) four-level pulse amplitude modulation (PAM4) optical wireless communication (OWC) system through a 200-m free-space transmission with either an 8.8-m piped water-air-piped water link or a 6.5-m turbid water-air-turbid water link is successfully constructed.	Water	222-227	WDM	Homo sapiens	45-48
34728720-5	2021	This demonstrates WDM-PAM4 OWC system outperforms existing OWC systems through the free-space transmission with an air-water-air link because it can solve the practical engineering problems in actual oceanic environments.	Water	119-124	WDM	Homo sapiens	18-21
34260333-6	2021	Mice were immunized with hIRBP peptide to induce EAU.	Water	49-52	retinol binding protein 3	Homo sapiens	25-30
34967854-8	2021	Conclusions: Our data demonstrate the therapeutic effect of IL-38 on EAU, and suggest that the effect of IL-38 may be caused by dampening of the GM-CSF/IL-23R/IL-23 feedback loop between Th17 cells and APCs.	Water	69-72	interleukin 23, alpha subunit p19	Mus musculus	159-164
16834443-8	2006	f-CNT 3, which instead possesses reduced solubility and forms mainly stable water suspensions, preserved lymphocytes" functionality while provoking secretion of proinflammatory cytokines by macrophages.	Water	76-81	solute carrier family 28 member 3	Homo sapiens	2-7
34250821-1	2021	Quantitative (15O)H2O positron emission tomography (PET) is the accepted reference method for regional cerebral blood flow (rCBF) quantification.	Water	18-21	CCAAT/enhancer binding protein zeta	Rattus norvegicus	124-128
34612088-9	2021	However, adult sucrose-treated female mice had smaller tibias and lower serum insulin-like growth factor-1 than adult water-treated female mice (p<=0.05); these effects were not observed in males.	Water	118-123	insulin-like growth factor 1	Mus musculus	78-106
34358983-1	2021	Using acid-treated corn stalk (CS) as biobased carrier, heterogeous SO42-/SnO2-CS catalyst was firstly prepared to catalyze CS into fufural in deep eutectic solvent-water system.	Water	165-170	citrate synthase	Homo sapiens	31-33
34186388-8	2021	Thus the SnS2 NSs can be effective for Cr(VI) contaminated waste-water treatment in a photocatalytic manner and can also act as a potential adsorbent for polluting dye molecules either in the presence or absence of sunlight.	Water	65-70	sodium voltage-gated channel alpha subunit 11	Homo sapiens	9-13
34358983-1	2021	Using acid-treated corn stalk (CS) as biobased carrier, heterogeous SO42-/SnO2-CS catalyst was firstly prepared to catalyze CS into fufural in deep eutectic solvent-water system.	Water	165-170	citrate synthase	Homo sapiens	79-81
16757556-5	2006	In our studies, we found that mouse testis-specific cytochrome c (T-Cc) can catalyze the reduction of H(2)O(2) three times faster than its counterpart in somatic cells (S-Cc) and that the T-Cc heme has the greater resistance to being degraded by H(2)O(2).	Water	102-107	cytochrome c, testis	Mus musculus	36-64
34358983-1	2021	Using acid-treated corn stalk (CS) as biobased carrier, heterogeous SO42-/SnO2-CS catalyst was firstly prepared to catalyze CS into fufural in deep eutectic solvent-water system.	Water	165-170	citrate synthase	Homo sapiens	124-126
34358983-3	2021	SO42-/SnO2-CS (1.2 wt%) could be used to catalyze CS (75.0 g/L) with MgCl2 (15.0 g/L) to produce furfural (102.3 mM) in the yield of 68.2% for 0.5 h at 170  C in ChCl:EG-water (20:80, v:v).	Water	170-175	strawberry notch homolog 1	Homo sapiens	6-9
34358983-3	2021	SO42-/SnO2-CS (1.2 wt%) could be used to catalyze CS (75.0 g/L) with MgCl2 (15.0 g/L) to produce furfural (102.3 mM) in the yield of 68.2% for 0.5 h at 170  C in ChCl:EG-water (20:80, v:v).	Water	170-175	citrate synthase	Homo sapiens	11-13
34358983-3	2021	SO42-/SnO2-CS (1.2 wt%) could be used to catalyze CS (75.0 g/L) with MgCl2 (15.0 g/L) to produce furfural (102.3 mM) in the yield of 68.2% for 0.5 h at 170  C in ChCl:EG-water (20:80, v:v).	Water	170-175	citrate synthase	Homo sapiens	50-52
34358983-5	2021	Finally, the potential catalytic mechanism for catalyzing CS into furfural and byproducts was proposed using SO42-/SnO2-CS as catalyst in ChCl:EG-water containing MgCl2.	Water	146-151	citrate synthase	Homo sapiens	58-60
34358983-5	2021	Finally, the potential catalytic mechanism for catalyzing CS into furfural and byproducts was proposed using SO42-/SnO2-CS as catalyst in ChCl:EG-water containing MgCl2.	Water	146-151	citrate synthase	Homo sapiens	120-122
34898995-9	2021	Conclusion: These findings suggest that the PPP2R1A rs11453459del>insG polymorphism is associated with an increased risk of PLC, especially for persons with a history of drinking pond-ditch water.	Water	190-195	protein phosphatase 2 scaffold subunit Aalpha	Homo sapiens	44-51
16757556-5	2006	In our studies, we found that mouse testis-specific cytochrome c (T-Cc) can catalyze the reduction of H(2)O(2) three times faster than its counterpart in somatic cells (S-Cc) and that the T-Cc heme has the greater resistance to being degraded by H(2)O(2).	Water	102-107	cytochrome c, testis	Mus musculus	66-70
16757556-5	2006	In our studies, we found that mouse testis-specific cytochrome c (T-Cc) can catalyze the reduction of H(2)O(2) three times faster than its counterpart in somatic cells (S-Cc) and that the T-Cc heme has the greater resistance to being degraded by H(2)O(2).	Water	102-107	cytochrome c, testis	Mus musculus	188-192
34885360-0	2021	Water Treatment from MB Using Zn-Ag MWCNT Synthesized by Double Arc Discharge.	Water	0-5	activity regulated cytoskeleton associated protein	Homo sapiens	64-67
34688659-7	2021	On the other hand, the conditional deletion of Dhps or Eif5a by Camk2a promoter-driven Cre expression (postnatal, mainly in the CA1 region of the hippocampus) did not lead to global developmental defects; rather, these knockout animals exhibited severe impairment in spatial learning, contextual learning, and memory when subjected to the Morris Water Maze and a contextual learning test.	Water	346-351	eukaryotic translation initiation factor 5A	Mus musculus	55-60
16679457-4	2006	Expression in Xenopus laevis oocytes demonstrated that NIP5;1 facilitated the transport of boric acid in addition to water.	Water	117-122	NOD26-like intrinsic protein 5;1	Arabidopsis thaliana	55-61
34346074-7	2021	Thus, this study suggests that SpGPAT5 can functionally replace AtGPAT5 and contributes to plant tolerance to high humidity, which maybe assist in understanding the role of suberin-associated waxes in S. purpurea pitchers for water retention.	Water	226-231	glycerol-3-phosphate acyltransferase 5	Arabidopsis thaliana	64-71
34632666-0	2021	Light- and pH-regulated Water-soluble Pseudorotaxanes Comprising a Cucurbit(7)uril and a Flavylium-based Axle.	Water	24-29	phenylalanine hydroxylase	Homo sapiens	11-13
34792359-1	2021	In this work, we study the water-gas shift (WGS) reaction catalyzed by alpha-MoC(100) supported typical platinum group metal (PGM) single atoms (Rh1, Pd1, and Pt1) and Au1 via density functional theory calculations.	Water	27-32	programmed cell death 1	Homo sapiens	150-153
16624361-5	2006	It was noted that the number of water-clear cells increased with aging, which are fairly consistent with the change of the serum parathyroid hormone (PTH) level.	Water	32-37	parathyroid hormone	Mus musculus	129-148
34947816-2	2021	Here we present the studies of several native chemokine receptors including CCR5, CCR9, CXCR2 and CXCR4 determined by X-ray crystallography, and their water-soluble QTY counter parts predicted by AlphaFold2.	Water	151-156	C-C motif chemokine receptor 9	Homo sapiens	82-86
34947816-2	2021	Here we present the studies of several native chemokine receptors including CCR5, CCR9, CXCR2 and CXCR4 determined by X-ray crystallography, and their water-soluble QTY counter parts predicted by AlphaFold2.	Water	151-156	C-X-C motif chemokine receptor 2	Homo sapiens	88-93
34830416-9	2021	Of note, we confirmed our data in isolated mouse mesentery patches, where we measured an AQP1-dependent transmesothelial osmotic water transport.	Water	129-134	aquaporin 1	Mus musculus	89-93
34830416-10	2021	These results suggest that the mesothelium may represent an additional selective barrier regulating water transport in PD through functional expression of the water channel AQP1.	Water	100-105	aquaporin 1	Mus musculus	173-177
34830416-10	2021	These results suggest that the mesothelium may represent an additional selective barrier regulating water transport in PD through functional expression of the water channel AQP1.	Water	159-164	aquaporin 1	Mus musculus	173-177
34765796-4	2021	Moreover, superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase enzyme activities, as well as reduced glutathione and malondialdehyde levels were significantly increased in heavy metals contained river water treated fish compared to the control.	Water	230-235	glutathione peroxidase	Oreochromis niloticus	42-64
34765796-4	2021	Moreover, superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase enzyme activities, as well as reduced glutathione and malondialdehyde levels were significantly increased in heavy metals contained river water treated fish compared to the control.	Water	230-235	glutathione S-transferase	Oreochromis niloticus	66-91
34765796-8	2021	The cytokines i.e. IL-1beta, IL-6, and TNF-alpha level were significantly (P < 0.01) increased in the fish exposed to heavy metals contained river water in comparison to that of control fish.	Water	147-152	interleukin-1 beta	Oreochromis niloticus	19-27
16846345-8	2006	The degradation of microspheres and the consequent FGF release became faster with an increase in the water content of gelatin microspheres.	Water	101-106	fibroblast growth factor 2	Rattus norvegicus	51-54
34822393-6	2021	Nonetheless, the cyp86a1-1 cyp86b1-1 mutant, which had a severely altered suberin composition and lamellae structure, exhibited increased water loss through the root periderm.	Water	138-143	cytochrome P450, family 86, subfamily A, polypeptide 1	Arabidopsis thaliana	17-24
34822393-7	2021	Cyp86a1-1 cyp86b1-1 also recorded lower relative water content in leaves.	Water	49-54	cytochrome P450, family 86, subfamily A, polypeptide 1	Arabidopsis thaliana	0-7
34328901-1	2021	Three mix-cultured aerobic denitrifiers were screened from a source water reservoir and named HE1, HE3 and SU4.	Water	68-73	NPC intracellular cholesterol transporter 2	Homo sapiens	94-97
34420733-3	2021	Compared with pure water, existed hydrated free ions in w:IL-9:1 and w:IL-7:3 restrict starch-water interactions to disaggregate of starch, thus hampering gelatinization of starch.	Water	19-24	interleukin 9	Homo sapiens	58-62
34420733-3	2021	Compared with pure water, existed hydrated free ions in w:IL-9:1 and w:IL-7:3 restrict starch-water interactions to disaggregate of starch, thus hampering gelatinization of starch.	Water	94-99	interleukin 9	Homo sapiens	58-62
16846345-9	2006	Less in situ formation of adipose tissue was observed at the lower water content of microspheres, which showed longer-term bFGF release.	Water	67-72	fibroblast growth factor 2	Rattus norvegicus	123-127
16511868-2	2006	Aquaporins (AQPs)-1, -4, and -9 have been identified as the three main water channels in the brain.	Water	71-76	aquaporin 1	Mus musculus	0-31
34709252-5	2021	must overcome a ~3.6 kJ mol-1 energy barrier; moreover, the CIP and solvent shared ion pair (SSIP) dynamically coexist for CaF2(H2O)14 in aqueous CaF2 solutions.	Water	128-131	CCR4-NOT transcription complex subunit 8	Homo sapiens	123-127
34709252-5	2021	must overcome a ~3.6 kJ mol-1 energy barrier; moreover, the CIP and solvent shared ion pair (SSIP) dynamically coexist for CaF2(H2O)14 in aqueous CaF2 solutions.	Water	128-131	CCR4-NOT transcription complex subunit 8	Homo sapiens	146-150
34709252-6	2021	Calculations for the dissociation process of CaF(H2O)6+ show a dramatic energy increase going from SSIP to free Ca2+ and F-, ascribed to the surprisingly long-range electrostatic attraction between Ca2+ and F- rather than to special F H interactions.	Water	49-52	lysine acetyltransferase 2B	Homo sapiens	45-48
34677929-4	2021	The tribo-motion between water droplets and air induced by the ultrasound wave leads to the generation of positive charges on the surface of the droplets, and the charge amount of water droplets (20 muL) gradually reaches saturation within 30 s. The mixed solid particles in droplets can increase the amount of transferred charge, whereas the increase of ion concentration in the droplet can suppress the charge generation.	Water	25-30	tripartite motif containing 37	Homo sapiens	199-202
34677929-4	2021	The tribo-motion between water droplets and air induced by the ultrasound wave leads to the generation of positive charges on the surface of the droplets, and the charge amount of water droplets (20 muL) gradually reaches saturation within 30 s. The mixed solid particles in droplets can increase the amount of transferred charge, whereas the increase of ion concentration in the droplet can suppress the charge generation.	Water	180-185	tripartite motif containing 37	Homo sapiens	199-202
34686736-1	2021	SLC4A11 is a H+/NH3/water transport protein, of corneal endothelial cells.	Water	20-25	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Mus musculus	0-7
16634620-3	2006	The data demonstrate the formation of an antiferromagnetically coupled, high-spin diiron(III/III) cluster upon treatment of solutions of Fe(II) and MIOX with excess O(2) or H(2)O(2) and the formation of an antiferromagnetically coupled, valence-localized, high-spin diiron(II/III) cluster upon treatment with either limiting O(2) or excess O(2) in the presence of a mild reductant (e.g., ascorbate).	Water	173-178	myo-inositol oxygenase	Homo sapiens	148-152
34364623-4	2021	The deposition of silica particles is able to compensate for the undesired increase in the hydrophilicity caused by the addition of chitosan, and tune the hydrophilic nature of the surface of the CA/CS films to the hydrophobic nature, which is desirable for water-resistant applications.	Water	258-263	citrate synthase	Homo sapiens	199-201
34977895-3	2021	In contrast, the isostructural Pt(II) barrel (TB2) is water-soluble.	Water	54-59	receptor accessory protein 5	Homo sapiens	46-49
34977895-4	2021	The large confined hydrophobic molecular cavity including wide open windows and good water solubility of the barrel TB2 made it a potential molecular container for the encapsulation of guests with different sizes and properties.	Water	85-90	receptor accessory protein 5	Homo sapiens	116-119
34977895-7	2021	Surprisingly, reverse switching of the cyclic form to a colored hydrophobic open form was also possible instantly in water upon addition of the solid barrel TB2 into an aqueous solution of G2.	Water	117-122	receptor accessory protein 5	Homo sapiens	157-160
34977895-9	2021	The barrel TB2 was also capable of encapsulating the water-insoluble radical initiator G1 in aqueous medium.	Water	53-58	receptor accessory protein 5	Homo sapiens	11-14
16461400-5	2006	In this study, we performed exhaustive molecular dynamics simulations in explicit water of the sweet protein MNEI and of its structural mutant G-16A, whose sweetness is one order of magnitude lower than that of MNEI.	Water	82-87	serpin family B member 1	Homo sapiens	109-113
34748612-9	2021	Marker WDP-9.21 was found associated with tuber fresh weigh under WD and gene annotation analysis revealed co-localization with the Glucan/water dikinase (GWD) gene.	Water	139-144	alpha-glucan water dikinase, chloroplastic	Solanum tuberosum	155-158
34455300-1	2021	We previously discovered extrahepatic cytochrome P450 1B1 (CYP1B1) degraders able to overcome drug resistance toward docetaxel using a PROTACs technology, however, the underexplored structure activity relationships and poor water solubility posed a major hurdle in the development of CYP1B1 degraders.	Water	224-229	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	38-57
34607432-3	2021	As expected, the resulting Fe-MOG/BC aerogel possesses a three-dimensional (3D) hierarchically porous microstructure and abundant active sites, being ultralight, water-fast, and mechanically robust.	Water	162-167	myelin oligodendrocyte glycoprotein	Homo sapiens	30-33
34607432-5	2021	Further, the Fe-MOG/BC aerogel enables efficient decontamination of 5 ppm of As(V) to below the permitted threshold in drinking water (10 ppb) within 30 min, accompanied by excellent selectivity and reusability.	Water	128-133	myelin oligodendrocyte glycoprotein	Homo sapiens	16-19
16850835-8	2006	Its water content was at 96.78%-98.14%, specific gravity 1.0064-1.016 , SVI of sludge 25 40 mL/g, COD removal loading could be reached to 1 5 kg/(m3 x d), nitrogen and phosphorus removal efficiency was more than 90%.	Water	4-9	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	98-101
34642412-2	2021	H2O) (SC1) and (Co (CN)6 (Me3Sn)3(H2O).	Water	0-3	transcription factor 19	Homo sapiens	6-9
34661985-9	2021	RESULTS: The experiment I showed that either low or high dose of ad-FoxO1 could significantly improve nerve function, reduce cerebral water content and reduce blood-brain barrier (BBB) destruction in rats, indicating that ad-FoxO1 had a protective effect on brain injury in rats EBI after SAH.	Water	134-139	forkhead box O1	Rattus norvegicus	68-73
34661985-9	2021	RESULTS: The experiment I showed that either low or high dose of ad-FoxO1 could significantly improve nerve function, reduce cerebral water content and reduce blood-brain barrier (BBB) destruction in rats, indicating that ad-FoxO1 had a protective effect on brain injury in rats EBI after SAH.	Water	134-139	forkhead box O1	Rattus norvegicus	225-230
16616585-8	2006	Thus, through the changes produced by the release of the enzyme from its site of action, we could demonstrate the physiological role of this peroxidase in the processing of root cell walls, being part of control mechanisms of ion and water fluxes through the root.	Water	234-239	peroxidase	Solanum lycopersicum	141-151
34927978-0	2021	Phase-Controllable Growth Nix Py Modified CdS@Ni3 S2 Electrodes for Efficient Electrocatalytic and Enhanced Photoassisted Electrocatalytic Overall Water Splitting.	Water	147-152	BCL2 interacting protein 3 like	Homo sapiens	26-29
34641597-10	2021	The EDIdrink values for DMP, DEP, DIBP, DBP, BMEP, DAP, BEEP, BBP, DCP, DHP, BMPP, BBEP, DEHP, DOP, and DNP through the consumption of bottled mineral water (based on mean concentrations) were 0.45, 0.33, 12.5, 3.67, 2.10, 0.06, 0.32, 0.16, 0.10, 0.09, 0.05, 0.81, 112, 0.13, and 0.20 ng/kg-bw/d, respectively, for Chinese adults.	Water	151-156	death associated protein	Homo sapiens	51-54
16722030-1	2006	BACKGROUND: This study investigated the association between serum N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels and extracellular water (ECW%) and left ventricular (LV) dysfunction in continuous ambulatory peritoneal dialysis (CAPD) patients.	Water	145-150	natriuretic peptide B	Homo sapiens	115-118
34224008-8	2021	Remarkably, the AKAPs-PKA disruptor FMP-API-1 increased transcellular water permeability in isolated renal collecting ducts to the same extent as vasopressin.	Water	70-75	baculoviral IAP repeat containing 2	Homo sapiens	40-45
34382413-6	2021	RESULTS: There were multiple differential methylation sites (DMS) of HLA-DPB1 and PDCD1LG2 genes in the total case and control population and the case and health control population with different water iodine levels.	Water	196-201	major histocompatibility complex, class II, DP beta 1	Homo sapiens	69-77
34382413-7	2021	Some target regions of HLA-DPB1 and PDCD1LG2 genes were negatively correlated with relative mRNA expression in the total case and control populations and in the case and control population with different water iodine levels.	Water	204-209	major histocompatibility complex, class II, DP beta 1	Homo sapiens	23-31
34382413-9	2021	The methylation patterns of HLA-DPB1 and PDCD1LG2 genes related to cell adhesion molecule pathway may be different under different areas with different water iodine levels.	Water	152-157	major histocompatibility complex, class II, DP beta 1	Homo sapiens	28-36
34456051-6	2021	Moreover, the ether-based AK/AZ-1 CuAAC network displayed comparable water stability in comparison to the BisGMA/TEGDMA network with slightly higher water sorption (46 mug/mm3vs 38 mug/mm3) and much lower water solubility (2.3 mug/mm3vs 4.4 mug/mm3).	Water	149-154	centrosomal protein 131	Homo sapiens	29-33
16771643-4	2006	When bone regeneration was evaluated by soft x-ray observation and bone mineral density (BMD) measurement, the gelatin hydrogels incorporating BMP- 2 exhibited significantly high osteoinduction activity compared with that of free BMP-2, although the activity depended on the water content of the hydrogels.	Water	275-280	bone morphogenetic protein 2	Oryctolagus cuniculus	143-149
34456051-6	2021	Moreover, the ether-based AK/AZ-1 CuAAC network displayed comparable water stability in comparison to the BisGMA/TEGDMA network with slightly higher water sorption (46 mug/mm3vs 38 mug/mm3) and much lower water solubility (2.3 mug/mm3vs 4.4 mug/mm3).	Water	205-210	centrosomal protein 131	Homo sapiens	29-33
34827220-3	2021	In Shiga toxin-producing E. coli (STEC) and enterohemorragic E. coli (EHEC) that are responsible for food- and water-borne outbreaks throughout the world, there are distinct differences of exo-xis region genes from their counterparts in lambda phage.	Water	111-116	exo	Escherichia virus Lambda	189-192
34665778-4	2021	Thus, water resources play an important role in transmitting Acanthamoeba spp.	Water	6-11	histocompatibility minor 13	Homo sapiens	74-77
16641327-2	2006	Waste paper applications to soils with high STP (soil test P) may decrease the risk of P transport to surface water by decreasing DRP (dissolved reactive P) by the formation of insoluble Al-P complexes and providing organic matter to improve infiltration.	Water	110-115	sulfotransferase family 1A member 1	Homo sapiens	49-60
34098276-5	2021	The results showed that the influence of particle size on the physical properties of substrates was significantly higher (P < 0.01) than the influence of the substrate type, especially with respect to the water-holding and aeration porosities, which had effect sizes (Eta2) of 73.8% and 68.2%, respectively.	Water	205-210	DNA polymerase iota	Homo sapiens	268-272
34683521-4	2021	NPI significantly decreased water absorption and slowed down the speed of water absorption of concrete.	Water	28-33	ADAM metallopeptidase with thrombospondin type 1 motif 2	Homo sapiens	0-3
34683521-4	2021	NPI significantly decreased water absorption and slowed down the speed of water absorption of concrete.	Water	74-79	ADAM metallopeptidase with thrombospondin type 1 motif 2	Homo sapiens	0-3
34143868-8	2021	In addition, each unit increase in %BAT was associated with lower ectopic fat at 4.5 years in the liver, -0.008 (-0.013, -0.003) %, soleus muscle, -0.003 (-0.006, -0.001) % of water-content and lower fatty liver index at 6 years.	Water	176-181	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	35-39
16459032-8	2006	Thus FD of HSPC liposomes using TBA/water cosolvent systems can provide sterile powder for specialized applications.	Water	36-41	proteasome 20S subunit alpha 7	Homo sapiens	11-15
34601677-5	2022	The results showed significant spatial variation in the lake water quality, with relatively high concentrations of TN, TP, CODMn, and Chl-a in East Dongting Lake.	Water	61-66	C-type lectin domain family 3 member B	Homo sapiens	115-117
34601677-11	2022	The water level had significant negative relationships with TN and TP concentrations and a significant positive relationship with CODMn concentration (p < 0.05).	Water	4-9	C-type lectin domain family 3 member B	Homo sapiens	60-62
34214560-0	2021	Facile fabrication of bifunctional SnO-NiO heteromixture for efficient electrocatalytic urea and water oxidation in urea-rich waste water.	Water	97-102	strawberry notch homolog 1	Homo sapiens	35-38
34214560-0	2021	Facile fabrication of bifunctional SnO-NiO heteromixture for efficient electrocatalytic urea and water oxidation in urea-rich waste water.	Water	132-137	strawberry notch homolog 1	Homo sapiens	35-38
16364461-0	2006	Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice.	Water	33-38	neuropeptide Y	Mus musculus	49-63
34659162-2	2021	In South Africa, information about the presence of ESBL/AmpC-producing Enterobacterales from non-clinical sources is limited, particularly in the water-plant-food interface.	Water	146-151	beta-lactamase	Klebsiella pneumoniae	56-60
34659162-3	2021	This study aimed to characterize 19 selected MDR ESBL/AmpC-producing Escherichia coli (n=3), Klebsiella pneumoniae (n=5), Serratia fonticola (n=10), and Salmonella enterica (n=1) isolates from spinach and associated irrigation water samples from two commercial spinach production systems within South Africa, using whole genome sequencing (WGS).	Water	227-232	beta-lactamase	Escherichia coli	54-58
34565396-10	2021	Activation of Frizzled-7 significantly improved neurological function, reduced brain water content and attenuated BBB permeability to large molecular weight substances after ICH.	Water	85-90	frizzled class receptor 7	Mus musculus	14-24
34528942-2	2021	Herein, a 3D network metal-organic framework ((Sm2(BTEC)1.5(H2O)8) 6H2O) with excellent thermal and water stability was synthesized by a hydrothermal method.	Water	60-63	SM2	Homo sapiens	47-50
16636453-1	2006	Soluble egg shell membrane protein (SEP) prepared from the egg shell membrane by performic acid oxidation and pepsin digestion was applied to prepare a membrane conjugated with pepsin-solubilized collagen (PSC) by cross-linking with water-soluble carbodiimide.	Water	233-238	membrane metalloendopeptidase like 1	Homo sapiens	36-39
34528942-2	2021	Herein, a 3D network metal-organic framework ((Sm2(BTEC)1.5(H2O)8) 6H2O) with excellent thermal and water stability was synthesized by a hydrothermal method.	Water	100-105	SM2	Homo sapiens	47-50
34331980-6	2021	CL90-Tw-SeNP2 possessed high stability and good dispersion in water for more than three months.	Water	62-67	SUMO specific peptidase 2	Homo sapiens	8-13
16646466-7	2006	Models of PAH adsorption using structures from molecular mechanics and energies from ab initio calculations do produce water-soot partitioning energies that correlate well with observed log(K(d)) values.	Water	119-124	phenylalanine hydroxylase	Homo sapiens	10-13
34482916-8	2021	BraA.cax1a-4 provided higher biomass and a better photosynthetic performance manifested by higher water use efficiency (WUE), Fv/Fm, electron fluxes, and Rubisco (EC 4.1.1.39) values.	Water	98-103	calnexin homolog 1	Brassica rapa	5-12
34681089-16	2021	ST1, ST2, ST3, ST4, ST5 and ST6 were shared by humans, animals, and water sources.	Water	68-73	DENN domain containing 2B	Homo sapiens	20-23
34399419-2	2021	We investigate the role of the main air constituents nitrogen, oxygen and water on the efficiency of radiative recombination in GaN nanostructures as a function of different surface treatments and at temperatures up to 200 C. Oxygen and water exposures exhibit a complex behavior as they can both act quenching and enhancing on the photoluminescence intensity dependent on the temperature.	Water	74-79	gigaxonin	Homo sapiens	128-131
34399419-2	2021	We investigate the role of the main air constituents nitrogen, oxygen and water on the efficiency of radiative recombination in GaN nanostructures as a function of different surface treatments and at temperatures up to 200 C. Oxygen and water exposures exhibit a complex behavior as they can both act quenching and enhancing on the photoluminescence intensity dependent on the temperature.	Water	237-242	gigaxonin	Homo sapiens	128-131
16677165-6	2006	RESULTS: H. pylori did not affect COX-1 expression; whereas COX-2 expression increased by six-fold at 24 h after incubation of RGM1 cells with 10 microg/mL H. pylori water extracts.	Water	166-171	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	60-65
34521831-4	2021	The biosensor, named SED1, utilizes the Arabidopsis intrinsically disordered AtLEA4-5 protein expressed in plants under water deficit.	Water	120-125	Late Embryogenesis Abundant 4-5	Arabidopsis thaliana	77-85
34397065-0	2021	Effects of doping on photocatalytic water splitting activities of PtS2/SnS2 van der Waals heterostructures.	Water	36-41	sodium voltage-gated channel alpha subunit 11	Homo sapiens	71-75
34491757-7	2021	This allowed to conclude that CS corresponded to a phase of liquid TG and to characterize them as lenses forming a three-phase (oil-water-air) system.	Water	132-137	citrate synthase	Homo sapiens	30-32
16619636-0	2006	Heavy water inhibiting the expression of transforming growth factor-beta1 and the development of kaolin-induced hydrocephalus in mice.	Water	6-11	transforming growth factor, beta 1	Mus musculus	41-73
34579130-5	2021	Compared with water-soluble beta-glucan, water-insoluble beta-glucan had higher DP3:DP4 molar ratio (2.12 and 1.67, respectively) and molecular weight (123,800 and 119,200 g/mol, respectively).	Water	14-19	transcription factor Dp 2	Mus musculus	80-83
34579130-5	2021	Compared with water-soluble beta-glucan, water-insoluble beta-glucan had higher DP3:DP4 molar ratio (2.12 and 1.67, respectively) and molecular weight (123,800 and 119,200 g/mol, respectively).	Water	41-46	transcription factor Dp 2	Mus musculus	80-83
34397065-7	2021	More importantly, from the PtS2/SnS2 to PtSe2/SnSe2 vdW heterojunction, the decomposition of water also changes from semi-decomposed water to fully decomposed water.	Water	93-98	sodium voltage-gated channel alpha subunit 11	Homo sapiens	32-36
34397065-7	2021	More importantly, from the PtS2/SnS2 to PtSe2/SnSe2 vdW heterojunction, the decomposition of water also changes from semi-decomposed water to fully decomposed water.	Water	133-138	sodium voltage-gated channel alpha subunit 11	Homo sapiens	32-36
34397065-7	2021	More importantly, from the PtS2/SnS2 to PtSe2/SnSe2 vdW heterojunction, the decomposition of water also changes from semi-decomposed water to fully decomposed water.	Water	159-164	sodium voltage-gated channel alpha subunit 11	Homo sapiens	32-36
34403579-5	2021	The successful densification of ZnO using H2O and Zn(acac)2 xH2O confirms the importance of speciation in CS, as ZnO has a very low solubility in pure H2O.	Water	42-45	citrate synthase	Homo sapiens	106-108
34597115-0	2021	Water Film Drainage between a Very Viscous Oil Drop and a Mica Surface.	Water	0-5	MHC class I polypeptide-related sequence A	Homo sapiens	58-62
16513981-0	2006	The rotational spectrum of the water-hydroperoxy radical (H2O-HO2) complex.	Water	31-36	heme oxygenase 2	Homo sapiens	62-65
34510456-0	2022	Activity of an Endo-1,4-beta-xylanase from Wheat Malt towards Water Unextractable Arabinoxylan Derived from Wheat.	Water	62-67	ENDO1	Homo sapiens	15-21
16513981-2	2006	We observed pure rotational transitions of the water-hydroperoxy radical complex, H2O-HO2, in a supersonic jet by means of a Fourier transform microwave spectrometer combined with a double-resonance technique.	Water	47-52	heme oxygenase 2	Homo sapiens	86-89
34575993-6	2021	However, we successfully reproduced the paradox effect of FSCPX in the rat model, mimicked the "paradox" effect of FSCPX with PSB-12379, and demonstrated the lipophilia of FSCPX, which could explain the negative outcome of inhibitor assays with CD39 and CD73 dissolved in a water-based solution.	Water	274-279	5' nucleotidase, ecto	Rattus norvegicus	254-258
34229394-0	2021	Catalytic decontamination of organic/inorganic pollutants in water and green H2 generation using nanoporous SnS2 micro-flower structured film.	Water	61-66	sodium voltage-gated channel alpha subunit 11	Homo sapiens	108-112
34229394-6	2021	Our results demonstrate the application of SnS2 nanoporous film as catalyst can be a significant greenery path for the removal of harmful inorganic/organic hazardous wastes from waste-water with simultaneous generation of green H2 fuel.	Water	184-189	sodium voltage-gated channel alpha subunit 11	Homo sapiens	43-47
16513981-2	2006	We observed pure rotational transitions of the water-hydroperoxy radical complex, H2O-HO2, in a supersonic jet by means of a Fourier transform microwave spectrometer combined with a double-resonance technique.	Water	82-85	heme oxygenase 2	Homo sapiens	86-89
16445883-6	2006	Sedimentation velocities of protein-coated particles in TGase-containing water-glycerol solutions were tracked with different levels of creatine.	Water	73-78	transglutaminase 1	Homo sapiens	56-61
34477105-6	2021	These results demonstrate that the conformational dynamics of GHSR are tightly coupled to the movements of internal water molecules, further enhancing our understanding of the molecular bases of GPCR-mediated signaling.	Water	116-121	growth hormone secretagogue receptor	Homo sapiens	62-66
34261012-2	2021	Decentralized water supply networks (WSN) can connect these regional groundwater resources with water users.	Water	14-19	Waisman syndrome	Homo sapiens	37-40
34261012-2	2021	Decentralized water supply networks (WSN) can connect these regional groundwater resources with water users.	Water	96-101	Waisman syndrome	Homo sapiens	37-40
34564237-0	2021	The Influence of the pH and Salinity of Water in Breeding Sites on the Occurrence and Community Composition of Immature Mosquitoes in the Green Belt of the City of Sao Paulo, Brazil.	Water	40-45	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	164-167
34564237-1	2021	The physicochemical parameters of water, such as pH, salinity, conductivity, and total dissolved solids, can influence mosquito larval development, survival, and abundance.	Water	34-39	phenylalanine hydroxylase	Homo sapiens	49-51
34564237-4	2021	The primary objective of this study was therefore to investigate the influence of the physicochemical parameters of water in different types of aquatic habitats on the occurrence of mosquito species in two remnants of Atlantic Forest in the city of Sao Paulo, Brazil.	Water	116-121	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	249-252
34564237-8	2021	There was a statistically significant association between mosquito species occurrence and pH and salinity, and the former had a significant influence on the mosquito species collected regardless of the type of aquatic habitat, showing that the pH of the breeding site water is an important factor in driving mosquito population dynamics and species distribution.	Water	268-273	phenylalanine hydroxylase	Homo sapiens	90-92
34564237-8	2021	There was a statistically significant association between mosquito species occurrence and pH and salinity, and the former had a significant influence on the mosquito species collected regardless of the type of aquatic habitat, showing that the pH of the breeding site water is an important factor in driving mosquito population dynamics and species distribution.	Water	268-273	phenylalanine hydroxylase	Homo sapiens	244-246
16609265-5	2006	AQP1 may be involved in water transfer across the blood vessel wall.	Water	24-29	aquaporin 1	Rattus norvegicus	0-4
34302405-3	2021	Herein, a universal compensation strategy was developed to introduce various polar organic molecules into the interlayer of Alx V2 O5  nH2 O by replacing partial crystal water.	Water	170-175	hematopoietic SH2 domain containing	Homo sapiens	124-127
34374511-4	2021	In particular, the PES@ZIF8-PSA/PES nanofiber membranes maintain outstanding air filtration and oil/water separation properties under the high temperature or strong acid/alkali conditions.	Water	100-105	pescadillo ribosomal biogenesis factor 1	Homo sapiens	19-27
34374511-4	2021	In particular, the PES@ZIF8-PSA/PES nanofiber membranes maintain outstanding air filtration and oil/water separation properties under the high temperature or strong acid/alkali conditions.	Water	100-105	pescadillo ribosomal biogenesis factor 1	Homo sapiens	32-35
16601568-2	2006	RESULTS: AT1-receptor activation by angiotensin II is not only involved in the regulation of blood pressure, water and sodium homeostasis, and control of other neurohumoral systems, but also leads to excessive production of reactive oxygen species and to hypertrophy, proliferation, migration, and apoptosis of vascular cells.	Water	109-114	angiotensin II receptor type 1	Homo sapiens	9-12
34589396-7	2021	Upon cleavage, the N-terminus of GsdmD (GsdmD-N) forms a transmembrane pore that releases cytokines such as IL-1beta and IL-18 and disturbs the regulation of ions and water, eventually resulting in strong inflammation and cell death.	Water	167-172	gasdermin D	Homo sapiens	40-47
34370950-0	2021	Molecular-Level Understanding of the Influence of Ions and Water on HMGB1 Adsorption Induced by Surface Hydroxylation of Titanium Implants.	Water	59-64	high mobility group box 1	Homo sapiens	68-73
16868674-9	2006	Aquaporin 1 (AQP1) is the only AQP present in these cells, and its deletion in AQP1 null mice significantly affects cell osmotic permeability but not fluid transport, which militates against the presence of sizable water movements across the cell.	Water	215-220	aquaporin 1	Mus musculus	0-11
34578480-2	2021	The demand in the application of nanomaterials can result in the release of these anthropogenic materials into soil and water that can potentially harm the environment by affecting water and soil properties (e.g., soil texture, pH, organic matter, and water content), plants, animals, and subsequently human health.	Water	120-125	phenylalanine hydroxylase	Homo sapiens	228-230
34254470-2	2021	In order to explore the stability and understand the transformation process of diphosphino-boryl-based PBP pincer platform, (PdCl{B(NCH2PtBu2)2-o-C6H4}) (1) was treated with PdCl2, HB(NCH2PPh2)2-o-C6H4 was reacted with (PdCl2(cod)) (cod = cyclo-octa-1,5-diene) and (Pd2(dba)3) (dba = dibenzylideneacetone), respectively, in the presence of water.	Water	340-345	dedicator of cytokinesis 3	Homo sapiens	103-106
34254470-4	2021	It was found that the PBP pincer backbone can easily be converted into a POP backbone in the presence of water.	Water	105-110	dedicator of cytokinesis 3	Homo sapiens	22-25
34237372-3	2021	After loading with BNNPs, water solubility (WS) and moisture absorption of the CS film decreased.	Water	26-31	citrate synthase	Homo sapiens	79-81
34237372-5	2021	Additionally, water vapor permeation decreased from 4.2 x 10-11 for pure CS film to 2.9 x 10-11 g m-1s-1Pa-1 at 7 wt% BNNP inclusion.	Water	14-19	citrate synthase	Homo sapiens	73-75
16868674-9	2006	Aquaporin 1 (AQP1) is the only AQP present in these cells, and its deletion in AQP1 null mice significantly affects cell osmotic permeability but not fluid transport, which militates against the presence of sizable water movements across the cell.	Water	215-220	aquaporin 1	Mus musculus	13-17
34503012-4	2021	More importantly, the HGP solution simulates the distribution of formation water in the Bohai SZ1-1 oilfield has good rheological properties at 120  C. All results show that the proposed polymer could be a competitive candidate in oilfield applications such as fracturing fluids, displacement fluids, and drilling fluids.	Water	75-80	DLG2 antisense RNA 1	Homo sapiens	94-99
34429648-13	2021	Conclusion: Our study shows significant perceived improvement from back pain after utilization of spa water.	Water	102-107	surfactant protein A1	Homo sapiens	98-101
34429648-15	2021	Therefore, hot spring spa water had better therapeutic effect for back pain and emphasis should be given to integrate it with modern medicine and further experimental study to be conducted to recommend it for medical purposes.	Water	26-31	surfactant protein A1	Homo sapiens	22-25
16868674-9	2006	Aquaporin 1 (AQP1) is the only AQP present in these cells, and its deletion in AQP1 null mice significantly affects cell osmotic permeability but not fluid transport, which militates against the presence of sizable water movements across the cell.	Water	215-220	aquaporin 1	Mus musculus	79-83
34501007-3	2021	However, due to its minimal water solubility, it is necessary to prepare a nanocarrier vehicle to aid in the delivery of this compound.	Water	28-33	activation induced cytidine deaminase	Homo sapiens	98-101
16159893-8	2006	NKCC1 null mice had a reduced capacity to excrete free water than wild-type mice, which resulted in hypochloremia following the NaCl-deficient diet.	Water	55-60	solute carrier family 12, member 2	Mus musculus	0-5
34448973-13	2021	Interleukin (IL) 1beta, IL-6, IL-8, and TNFalpha were also increased in the T1DM mice with water deprivation.	Water	91-96	chemokine (C-X-C motif) ligand 15	Mus musculus	30-34
34436390-3	2021	As a result, the FAU-type zeolite membrane prepared using a solution with a composition of 10 SiO2:1 Al2O3:17 Na2O:1000 H2O showed the highest permeation flux of 86,600 mumol m-2 s-1 and a separation factor of 6020 for a 10 wt% methanol/methyl hexanoate mixture at 353 K. The membrane showed a molecular sieving effect, reducing the single permeation flux of alcohol with molecular size for single-component alcohols.	Water	120-123	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	17-20
15961059-1	2006	OBJECTIVE: Carbonic anhydrase (CA) VI is a unique secreted isozyme of CA, which catalyzes the reversible reaction CO2 +H2O&lt;--&gt;H+ +HCO3-.	Water	119-122	carbonic anhydrase 6	Homo sapiens	11-37
34313292-2	2021	Human islet amyloid polypeptide (hIAPP, involved in type II diabetes) spontaneously undergoes liquid-liquid phase separation (LLPS) and a kinetically complex hydrogelation, both catalysed by hydrophobic-hydrophilic interfaces (e.g. air-water interface and/or phospholipids-water interfaces).	Water	236-241	islet amyloid polypeptide	Homo sapiens	33-38
34313292-2	2021	Human islet amyloid polypeptide (hIAPP, involved in type II diabetes) spontaneously undergoes liquid-liquid phase separation (LLPS) and a kinetically complex hydrogelation, both catalysed by hydrophobic-hydrophilic interfaces (e.g. air-water interface and/or phospholipids-water interfaces).	Water	273-278	islet amyloid polypeptide	Homo sapiens	33-38
34259294-2	2021	In this work, a simple and efficient congenerous-exfoliation strategy was developed to prepare vast and uniform few-layered Ni2+@Ce-MOF (Ce-MOF: {(Ce(HPIA)(PIA)(H2O)2) H2O}n) nanosheets with a thickness of ca.	Water	161-164	lysine acetyltransferase 8	Homo sapiens	132-135
34259294-2	2021	In this work, a simple and efficient congenerous-exfoliation strategy was developed to prepare vast and uniform few-layered Ni2+@Ce-MOF (Ce-MOF: {(Ce(HPIA)(PIA)(H2O)2) H2O}n) nanosheets with a thickness of ca.	Water	161-164	lysine acetyltransferase 8	Homo sapiens	140-143
34259294-2	2021	In this work, a simple and efficient congenerous-exfoliation strategy was developed to prepare vast and uniform few-layered Ni2+@Ce-MOF (Ce-MOF: {(Ce(HPIA)(PIA)(H2O)2) H2O}n) nanosheets with a thickness of ca.	Water	168-171	lysine acetyltransferase 8	Homo sapiens	132-135
34259294-2	2021	In this work, a simple and efficient congenerous-exfoliation strategy was developed to prepare vast and uniform few-layered Ni2+@Ce-MOF (Ce-MOF: {(Ce(HPIA)(PIA)(H2O)2) H2O}n) nanosheets with a thickness of ca.	Water	168-171	lysine acetyltransferase 8	Homo sapiens	140-143
16052238-2	2006	Our results demonstrate that water molecules in apoptotic mitochondria exhibit an accelerated translational motion of structured water common with that induced by the opening of the PTP, but limited in amplitude.	Water	29-34	protein tyrosine phosphatase receptor type U	Homo sapiens	182-185
34418919-7	2021	We demonstrate the utility of the two MLP interfaces for two relevant example applications: the investigation of diffusion phenomena in liquid water and the equilibration of nanostructured amorphous battery materials.	Water	143-148	cysteine and glycine rich protein 3	Homo sapiens	38-41
34390784-1	2021	BACKGROUND: Ammonium persulfate (APS), an oxidizing agent used in hair products, manufacturing, and pool/spa water, can cause skin reactions including allergic contact dermatitis.	Water	109-114	surfactant protein A1	Homo sapiens	105-108
16052238-2	2006	Our results demonstrate that water molecules in apoptotic mitochondria exhibit an accelerated translational motion of structured water common with that induced by the opening of the PTP, but limited in amplitude.	Water	129-134	protein tyrosine phosphatase receptor type U	Homo sapiens	182-185
34232129-0	2021	Inhibition of CAMK II modulates water permeability by reducing AQP4 expression in astrocytes after oxygen-glucose deprivation.	Water	32-37	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	14-21
16052238-4	2006	We conclude that the changes observed in the different water phases differ both quantitatively and qualitatively during the opening of the PTP and the Bax alpha-induced permeability, and that the apoptotic mitochondria exhibit mixed properties between these model situations.	Water	55-60	protein tyrosine phosphatase receptor type U	Homo sapiens	139-142
34232129-10	2021	Inhibition of CaMK II resulted in reduced astrocyte water permeability and AQP4 expression.	Water	52-57	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	14-21
34451066-1	2021	We show that an SnO2-based water-gate thin film transistor (WGTFT) biosensor responds to a waterborne analyte, the spike protein of the SARS-CoV-2 virus, by a parallel potentiometric and capacitive mechanism.	Water	27-32	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	115-120
16467332-6	2006	Expression of NOD2, IFN-beta, and IL-12p40 was higher with LF administration than with water or BSA administration.	Water	87-92	nucleotide-binding oligomerization domain containing 2	Mus musculus	14-18
34374547-5	2021	We report the detection of frequency fluctuations of an azide anion (N3-) bound in the active site of the protein carbonic anhydrase II, where a low-frequency mode of the protein has been proposed to facilitate proton transfer over two water molecules during the catalyzed reaction.	Water	236-241	carbonic anhydrase 2	Bos taurus	114-135
34443161-2	2021	The study found that the paper can realize the reversible control of surface wettability through the exchange between the anions PF6- and Cl- adsorbed on the surface of PMETAC, and further investigation of the effect of different solvents on the ion exchange properties found that water was the poor solvent for ion exchange, while the mixtures of methanol, acetone, and methanol & water were the good solvent.	Water	281-286	sperm associated antigen 17	Homo sapiens	129-132
34386768-5	2021	After the four-week training, the time required for on-water paddling for 270 m was reduced by 7.3% from pre to post training, while the average impulse in the x-direction significantly (P < 0.001, partial eta squared (eta2) = 0.82) increased from 71.9 +- 1.9 to 91.1 +- 5.4 N kg-1 s-1.	Water	55-60	DNA polymerase iota	Homo sapiens	219-223
16249932-8	2006	Repeating the oral water load immediately after normalization of urine flow rate, however, resulted in delayed diuresis and higher urinary vasopressin/creatinine ratios in taut-/- mice.	Water	19-24	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	Mus musculus	172-176
34337607-3	2021	Here we show by a combined computational design, experimental, and molecular dynamics (MD) study that local mutations have not only a local but also a global effect on the solvent: In the specific case of the matrix metalloprotease MMP14, we found that the nature of local mutations, coupled with surface morphology, have the ability to influence large patches of the water hydrogen-bonding network at the protein surface, which is correlated with stability.	Water	368-373	matrix metallopeptidase 14	Homo sapiens	232-237
34297539-3	2021	Under near-infrared (NIR) light irradiation, the LSSF quickly bent toward the CS layer with a large bending angle (>200 ), high sensitivity (~7  C change), and great repeatability (>1000 cycles), which was attributed to the significant difference in the coefficient of thermal expansion (CTE) between CS and PVDF and the water desorption-induced volume shrinking in the CS layer.	Water	321-326	citrate synthase	Homo sapiens	78-80
34297539-3	2021	Under near-infrared (NIR) light irradiation, the LSSF quickly bent toward the CS layer with a large bending angle (>200 ), high sensitivity (~7  C change), and great repeatability (>1000 cycles), which was attributed to the significant difference in the coefficient of thermal expansion (CTE) between CS and PVDF and the water desorption-induced volume shrinking in the CS layer.	Water	321-326	citrate synthase	Homo sapiens	370-372
16249932-11	2006	Upon free access to water after deprivation, taut-/- mice continued to concentrate urine up to 6 days, while taut+/+ mice rapidly returned to normal urinary osmolality.	Water	20-25	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	Mus musculus	45-49
16338960-0	2006	Photoinactivation of ascorbate peroxidase in isolated tobacco chloroplasts: Galdieria partita APX maintains the electron flux through the water-water cycle in transplastomic tobacco plants.	Water	138-143	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	94-97
34445069-2	2021	By a green peptide synthesis protocol, we produced two water-soluble analogs of the peptaibol trichogin GA IV, termed K6-Lol and K6-NH2.	Water	55-60	lysyl oxidase like 1	Homo sapiens	121-124
34513548-1	2021	Cytochrome c oxidase (CcO), a terminal oxidase in the respiratory chain, catalyzes the reduction of O2 to water coupled with the proton pump across the membrane.	Water	106-111	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
34513548-1	2021	Cytochrome c oxidase (CcO), a terminal oxidase in the respiratory chain, catalyzes the reduction of O2 to water coupled with the proton pump across the membrane.	Water	106-111	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
34513548-6	2021	In the structure of monomeric CcO, a hydrogen bond network of water molecules is formed at the entrance of the proton transfer K-pathway, and in dimeric CcO, this network is altered by a cholate molecule binding between monomers.	Water	62-67	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	30-33
16338960-0	2006	Photoinactivation of ascorbate peroxidase in isolated tobacco chloroplasts: Galdieria partita APX maintains the electron flux through the water-water cycle in transplastomic tobacco plants.	Water	144-149	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	94-97
34348575-3	2021	PURPOSE: This review describes the development and the preclinical testing of a cationic oil-in-water emulsion of CsA (CE-CsA) in terms of pharmacodynamics, pharmacokinetics, and ocular tolerance.	Water	96-101	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	114-117
34348575-3	2021	PURPOSE: This review describes the development and the preclinical testing of a cationic oil-in-water emulsion of CsA (CE-CsA) in terms of pharmacodynamics, pharmacokinetics, and ocular tolerance.	Water	96-101	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	122-125
34264383-3	2021	The fluorescence of the TPE@SNW-1 strongly depends on the composition of tetrahydrofuran-water binary system.	Water	89-94	SNW domain containing 1	Homo sapiens	28-33
16471593-3	2006	Due to the 3d3 configuration of Cr3+, this unusual tetrahedral coordination environment strongly tends to transform into the more stable 6-fold coordination geometry by binding two extraframework water molecules during hydration.	Water	196-201	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	32-35
34170099-0	2021	Reduced Red Mud as the Solar Absorber for Solar-Driven Water Evaporation and Vapor-Electricity Generation.	Water	55-60	adaptor related protein complex 5 subunit mu 1	Homo sapiens	12-15
34170099-1	2021	The emergent solar-driven water evaporation technology provides a reassuring scheme for red mud (RM) utilization in environment and materials science.	Water	26-31	adaptor related protein complex 5 subunit mu 1	Homo sapiens	92-95
34348143-3	2021	We demonstrate that a specific miRNA (miR-466f-3p) is upregulated in the hippocampus of a portion of individual inbred mice upon a Morris water maze task.	Water	138-143	microRNA 466f-3	Mus musculus	38-49
16331442-1	2006	The objective of this research was to determine the optimum total organic halogen (TOX) protocol for use with ion chromatographic (IC) detection to analyze total organic chlorine (TOCl), bromine (TOBr), and iodine (TOI) in drinking water simultaneously.	Water	232-237	thymocyte selection associated high mobility group box	Homo sapiens	83-86
34365054-6	2021	FINDINGS: Mean +- SD fat signal fraction was significantly lower in the neuropathic subjects than in the healthy controls (0.55 +- 0.11 vs. 0.72 +- 0.03, p < 0.005), and was explained by a lowering in fat signal (R2 0.87), more than an increase in water signal (R2 0.32).	Water	248-253	FAT atypical cadherin 1	Homo sapiens	21-24
34087204-1	2021	Lens-specific beaded filament (BF) proteins CP49 and filensin interact with the C-terminus of the water channel Aquaporin 0 (AQP0).	Water	98-103	beaded filament structural protein 1, in lens-CP94	Mus musculus	53-61
34180926-4	2021	Moreover, the heat capacity of these carbohydrates in mixtures with water was measured by DSC in a broad range of water contents.	Water	68-73	desmocollin 3	Homo sapiens	90-93
34180926-4	2021	Moreover, the heat capacity of these carbohydrates in mixtures with water was measured by DSC in a broad range of water contents.	Water	114-119	desmocollin 3	Homo sapiens	90-93
34218090-3	2021	Strict regulations prohibit the use of substances that can be used to estimate aquifer residence times to define water protection areas for bank filtration.	Water	113-118	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	140-144
16339784-6	2006	Quantification of low water potential-induced ABA and Pro accumulation in five ABA-insensitive mutants, abi1-1, abi2-1, abi3, abi4, and abi5, revealed that abi4 had increased Pro accumulation at low water potential, but a reduced response to exogenous ABA.	Water	22-27	Protein phosphatase 2C family protein	Arabidopsis thaliana	104-110
34329447-2	2021	METHODS: We examine the relationship between disease multimorbidity and brain activity using regional cerebral blood flow (rCBF) 15O-water PET scans from 97 cognitively normal participants (mean baseline age 76.5) in the Baltimore Longitudinal Study of Aging (BLSA).	Water	133-138	CCAAT/enhancer binding protein zeta	Rattus norvegicus	123-127
16339784-6	2006	Quantification of low water potential-induced ABA and Pro accumulation in five ABA-insensitive mutants, abi1-1, abi2-1, abi3, abi4, and abi5, revealed that abi4 had increased Pro accumulation at low water potential, but a reduced response to exogenous ABA.	Water	22-27	Protein phosphatase 2C family protein	Arabidopsis thaliana	112-116
34107687-3	2021	We consider six of the popular nonpolarizable water models-SPC/E, SPC/Fw, TIP3P, TIP3P_M (modified), TIP4P-2005, and TIP4P-2005f-and find that the in-plane structure of the water molecules at ambient temperature and pressure is strongly dependent on the water model: all the 3-point water models considered here show square ice formation, whereas no such structural ordering is observed for the 4-point water models.	Water	173-178	urocortin 3	Homo sapiens	59-62
16408120-7	2006	Water restriction significantly (P&lt;0.05) increased the abundance of Na-K-2Cl cotransporter (NKCC2) and Na-Cl cotransporter (NCC) across ages.	Water	0-5	solute carrier family 12 member 3	Rattus norvegicus	106-125
34107687-3	2021	We consider six of the popular nonpolarizable water models-SPC/E, SPC/Fw, TIP3P, TIP3P_M (modified), TIP4P-2005, and TIP4P-2005f-and find that the in-plane structure of the water molecules at ambient temperature and pressure is strongly dependent on the water model: all the 3-point water models considered here show square ice formation, whereas no such structural ordering is observed for the 4-point water models.	Water	173-178	urocortin 3	Homo sapiens	66-69
34105546-2	2021	By studying the VSFG spectra in the regions of 1050-1450 cm-1, 2750-3180 cm-1, and 3200-3825 cm-1, it was concluded that in the presence of Ca2+ ions, the head groups together with the head-group-bound water molecules in the DPPC monolayer are strongly influenced by the interaction with CS, while the organization of the phospholipid tails remains mostly unchanged.	Water	202-207	citrate synthase	Homo sapiens	288-290
34341770-4	2021	The hydrocarbon/water interfaces are functionalized with a secondary antibody of IgG protein and SARS-CoV-2 spike receptor binding domain (RBD), to produce two different Janus emulsions.	Water	16-21	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	108-113
34282419-3	2021	Here we show that water-soluble derivatives of alpha-tocopherol have potent antiviral activity and synergize with remdesivir as inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).	Water	18-23	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	187-191
34282419-5	2021	We subsequently determined that TPGS and other water-soluble derivatives of alpha-tocopherol inhibit the transcriptional activity of purified SARS-CoV-2 RdRp and identified affinity binding sites for these compounds within a conserved, hydrophobic interface between SARS-CoV-2 nonstructural protein 7 and nonstructural protein 8 that is functionally implicated in the assembly of the SARS-CoV-2 RdRp 6 .	Water	47-52	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	153-157
16408120-7	2006	Water restriction significantly (P&lt;0.05) increased the abundance of Na-K-2Cl cotransporter (NKCC2) and Na-Cl cotransporter (NCC) across ages.	Water	0-5	solute carrier family 12 member 3	Rattus norvegicus	127-130
16244498-2	2006	As a significant fraction of renal salt and water transport is mediated by the proximal tubular Na+/H+ exchanger NHE3, we investigated its regulation in rats with STZ-induced diabetes mellitus.	Water	44-49	solute carrier family 9 member A3	Rattus norvegicus	113-117
34381441-12	2021	Also, Bcl-2, Bax, MMP-9, ZO-1 protein levels; Evans blue, TUNEL, and Nissl staining; brain water content; and modified Garcia score showed that A20 exerted a neuroprotective effect after SAH.	Water	91-96	TNF alpha induced protein 3	Homo sapiens	144-147
34452078-2	2021	Here, we selected halloysite (HAL) clay as a biocompatible, non-toxic material that is useful as a drug delivery system to enhance the healing properties of water-soluble terpenoids 1-3 (T1-3).	Water	157-162	interleukin 1 receptor like 1	Homo sapiens	187-191
34289850-12	2021	The screening of the biological activities of stigmas water extract (up to 100 mug/mL) including anti-allergic, anti-virus, anti-neuraminidase, and anti-inflammatory effects revealed its inhibitory activity against neuraminidase enzyme by 41%.	Water	54-59	neuraminidase 1	Homo sapiens	129-142
34289850-12	2021	The screening of the biological activities of stigmas water extract (up to 100 mug/mL) including anti-allergic, anti-virus, anti-neuraminidase, and anti-inflammatory effects revealed its inhibitory activity against neuraminidase enzyme by 41%.	Water	54-59	neuraminidase 1	Homo sapiens	215-228
34223568-2	2021	Herein, three mononuclear Eu3+ complexes based on bis-beta-diketone ligands (L1, L2 and L3) that can reduce luminescence quenching caused by water were developed.	Water	141-146	immunoglobulin kappa variable 3-15	Homo sapiens	81-90
34266277-11	2021	The relative abundance of ML1 is shown to decrease from ~96% in gas to ~51% in water and ~92% in methanol.	Water	79-84	interleukin 17F	Homo sapiens	26-29
34356423-0	2021	Assessment and Prediction of Water Resources Vulnerability Based on a NRS-RF Model: A Case Study of the Song-Liao River Basin, China.	Water	29-34	sphingolipid transporter 1 (putative)	Homo sapiens	70-73
34356423-3	2021	Based on the constructed indicator system of water resources vulnerability assessment in Song-Liao River Basin, this paper uses the neighborhood rough set (abbreviated as NRS) method to reduce the dimensionality of the original indicator system to remove redundant attributes.	Water	45-50	sphingolipid transporter 1 (putative)	Homo sapiens	171-174
34231993-3	2021	An important physiological process for retaining water in epidermal cells is the taurine transporter (TauT).	Water	49-54	solute carrier family 6 member 6	Homo sapiens	81-100
34231993-3	2021	An important physiological process for retaining water in epidermal cells is the taurine transporter (TauT).	Water	49-54	solute carrier family 6 member 6	Homo sapiens	102-106
34210097-11	2021	The consumption of 20% fructose water by Wistar rats for eight weeks displayed a tremendous increment in body weight, fat mass, percentage fat, LDL, TG, TC, HMG-CoA reductase, leptin, and reduced the levels of HDL and adiponectin as well as adipocyte hypertrophy.	Water	32-37	leptin	Rattus norvegicus	176-182
34170847-8	2021	PD-1 antibody or BMS-1 was successfully conjugated to the decellularized rat thoracic artery patch by hyaluronic acid with altered morphology and reduced the water contact angle (WCA).	Water	158-163	programmed cell death 1	Homo sapiens	0-4
34159366-1	2022	Electrospun polyacrylonitrile/clinoptilolite (PAN/CP) nanofibers were used to extract polycyclic aromatic hydrocarbons (PAHs) (acenaphthene, acenaphthylene, naphthalene, and phenanthrene) from water samples by solid-phase microextraction (SPME).	Water	193-198	adenosine deaminase 2	Homo sapiens	46-52
34127712-2	2021	Lactoperoxidase (LPO) catalyzes the redox reaction of reducing highly reactive H2O2 to H2O while oxidizing thiocyanate (SCN-) to relatively tissue-innocuous hypothiocyanite (OSCN-).	Water	87-90	lactoperoxidase	Mus musculus	0-15
34127712-2	2021	Lactoperoxidase (LPO) catalyzes the redox reaction of reducing highly reactive H2O2 to H2O while oxidizing thiocyanate (SCN-) to relatively tissue-innocuous hypothiocyanite (OSCN-).	Water	87-90	lactoperoxidase	Mus musculus	17-20
34349903-2	2021	Because the catenulate (GaF(H2O))2+ framework serves as a template for the favorable assembly of the polar (IO3F)2- groups and contributes to the nonlinear coefficient, (GaF(H2O))(IO3F) exhibits a greatly improved second-harmonic generation (SHG) effect of 10 times that of KH2PO4 (KDP) and a considerable band gap of 4.34 eV compared to the parent compound CsIO2F2 (3 x KDP, 4.5 eV).	Water	28-31	WNK lysine deficient protein kinase 1	Homo sapiens	282-285
34349903-2	2021	Because the catenulate (GaF(H2O))2+ framework serves as a template for the favorable assembly of the polar (IO3F)2- groups and contributes to the nonlinear coefficient, (GaF(H2O))(IO3F) exhibits a greatly improved second-harmonic generation (SHG) effect of 10 times that of KH2PO4 (KDP) and a considerable band gap of 4.34 eV compared to the parent compound CsIO2F2 (3 x KDP, 4.5 eV).	Water	174-177	WNK lysine deficient protein kinase 1	Homo sapiens	371-374
34076793-1	2021	In most fish exhibiting external fertilization, spermatozoa become motile after release into water, triggered by differences between intracellular and extracellular conditions such as osmotic pressure, ion composition, and pH.	Water	93-98	phenylalanine hydroxylase	Homo sapiens	223-225
34122018-1	2021	Urea transporter B (UT-B) is a membrane channel protein widely distributed in mammals, and plays a significant physiological role by regulating urea and water transportation in different tissues.	Water	153-158	solute carrier family 14 (urea transporter), member 1	Mus musculus	0-18
34122018-1	2021	Urea transporter B (UT-B) is a membrane channel protein widely distributed in mammals, and plays a significant physiological role by regulating urea and water transportation in different tissues.	Water	153-158	solute carrier family 14 (urea transporter), member 1	Mus musculus	20-24
34069533-0	2021	Deciphering the Molecular Mechanism of Water Interaction with Gelatin Methacryloyl Hydrogels: Role of Ionic Strength, pH, Drug Loading and Hydrogel Network Characteristics.	Water	39-44	phenylalanine hydroxylase	Homo sapiens	118-120
34258154-5	2021	As revealed by ultrafast transient absorption spectroscopy and first-principles simulations, the new Schottky junction (PtPd (100)@UiO-66-NH2) with higher V transfer and V consume exhibits enhanced electron-hole separation and H2O activation than the traditional Pt/UiO-66-NH2 junction, thereby leading to a significant enhancement in the photoactivity.	Water	227-230	protein tyrosine phosphatase receptor type D	Homo sapiens	120-124
34821330-10	2021	It is supposed that the synergistic interactions of the adhesive catechol group, displacement of water on the wet skin surface by the positively charged -NH3+ groups of CS and the water-repelling potential of the hydrophobic unit of the catechol derivative, the protection of the catechol group from oxidation into a less adhesive quinone group, and the energy dissipation capacity of the mechanically tough hydrogel contribute to the strong and repeatable wet tissue adhesion.	Water	97-102	citrate synthase	Homo sapiens	169-171
34141823-6	2021	Then, through loss- and gain-of-function assays, USP11 knockdown was revealed to alleviate ICH-induced symptoms, corresponding to reduced modified neurological severity scores (mNSS) value, brain water content, blood-brain barrier permeability, neuron apoptosis, microglial cell activation, neutrophil infiltration, and inflammatory factor secretion.	Water	196-201	ubiquitin specific peptidase 11	Rattus norvegicus	49-54
34421214-3	2021	Mechanisms that drive proteins into the NTP or NDP conformation may depend on factors such as ligand structure and how Mg2+ coordinates with the ligand, amino acids in the pocket and water molecules.	Water	183-188	norrin cystine knot growth factor NDP	Homo sapiens	47-50
34989203-11	2021	Drinking 1% H<sub>2</sub>O<sub>2</sub> water significantly (p<u><</u>0.01)decreased the estrous cycle time, body, ovary and uterus weights, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone and estrogen (E2) levels, uterine and ovarian superoxide dismutase (SOD) activity and reduced glutathione (GSH) level while caused a substantial increase (p<u><</u>0.01) in uterine and ovarian malondialdehyde (MDA) level, DNA fragmentation percent, caspase-3 (Casp-3), 8-hydroxydeoxyguanosine (8-OHdG), tumour necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2) levels as well as cyclooxygenase-2 (COX-2) activity.	Water	39-44	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	608-624
34989203-11	2021	Drinking 1% H<sub>2</sub>O<sub>2</sub> water significantly (p<u><</u>0.01)decreased the estrous cycle time, body, ovary and uterus weights, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone and estrogen (E2) levels, uterine and ovarian superoxide dismutase (SOD) activity and reduced glutathione (GSH) level while caused a substantial increase (p<u><</u>0.01) in uterine and ovarian malondialdehyde (MDA) level, DNA fragmentation percent, caspase-3 (Casp-3), 8-hydroxydeoxyguanosine (8-OHdG), tumour necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2) levels as well as cyclooxygenase-2 (COX-2) activity.	Water	39-44	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	626-631
34248011-2	2021	A 24 factorial design was employed to check the effect of four factors namely pH, current density, electrolysis time and electrolyte concentration set at their high (+) and low (-) levels on the antibiotics (amoxicillin, ciprofloxacin and erythromycin) degradation in water.	Water	268-273	phenylalanine hydroxylase	Homo sapiens	78-80
35439507-0	2022	Indole and quinolizidine alkaloids from blue lupin leach to agricultural drainage water.	Water	82-87	5'-nucleotidase, cytosolic IIIA	Homo sapiens	45-50
35439507-10	2022	These findings indicate that drainage from lupin cultivated areas contribute to surface water contamination.	Water	88-93	5'-nucleotidase, cytosolic IIIA	Homo sapiens	43-48
35183964-0	2022	pH-driven-assembled soy peptide nanoparticles as particulate emulsifier for oil-in-water Pickering emulsion and their potential for encapsulation of vitamin D3.	Water	83-88	phenylalanine hydroxylase	Homo sapiens	0-2
35351576-0	2022	The water extract of Radix scutellariae, its total flavonoids and baicalin inhibited CYP7A1 expression, improved bile acid, and glycolipid metabolism in T2DM mice.	Water	4-9	glucosidase beta 2	Mus musculus	113-122
35351576-3	2022	Our previous studies found that the water extract of Radix scutellariae (WESB) could exert hypoglycemic and hypolipidemic efficacies by adjusting the ileum FXR-medicated interaction between gut microbiota and bile acid (BA) metabolism.	Water	36-41	glucosidase beta 2	Mus musculus	209-218
35472754-6	2022	Additionally, the OE-CBL plants increased their tolerance to osmotic stress by increasing the transcription levels of drought-related genes and their relative water-loss rates.	Water	159-164	cystathionine beta-lyase	Arabidopsis thaliana	21-24
34194414-3	2021	Here, we present a novel method for estimating the Chl a content and photosynthetic microalgal cell density in water samples using the integral area of the OJIP curve.	Water	111-116	chordin like 1	Homo sapiens	51-54
34074350-9	2021	Furthermore, total water intake/weight was positively correlated with percentage of body water (r = 0.357, P = 0.000) and negatively with body fat (kg) (r = - 0.427, P = 0.000), percentage of body fat (r = - 0.405, P = 0.000), and waist/hip ratio (r = - 0.223, P = 0.002).	Water	19-24	hedgehog interacting protein	Homo sapiens	237-240
34085453-7	2021	This review summarizes the advances in metabolic engineering for vitamins production in the past 30 years, with a focus on production of water-soluble vitamins (vitamins B1, B2, B3, B5, B6, B7, B9, B12 and vitamin C precursors) and lipid-soluble vitamins (vitamin A, precursors of vitamin D, vitamin E and vitamin K).	Water	137-142	CD80 molecule	Homo sapiens	161-196
34240910-5	2021	At room temperature, SPC/E-HW and TIP3P-HW capture the modulations relative to light water of the mass and electron densities, heat of vaporization, diffusion coefficient, and water structure.	Water	176-181	urocortin 3	Homo sapiens	21-24
34104203-8	2021	We also found that the water extract enhanced gut integrity and decreased gut inflammatory protein ICAM-1 expression in db/db mice as detected by H&E staining and immunohistochemistry methods.	Water	23-28	intercellular adhesion molecule 1	Mus musculus	99-105
34069397-4	2021	AtGRXS17-expressing lines showed higher relative water content, higher chlorophyll content, and less hydrogen peroxide accumulation than wild-type (WT) control plants under drought conditions.	Water	49-54	thioredoxin family protein	Arabidopsis thaliana	0-8
34134341-10	2021	A marginal stability analysis for different beta shows that a 3-muL water droplet is unstable to the m=1 mode when the contact angle beta is larger than 130^{ }.	Water	68-73	tripartite motif containing 37	Homo sapiens	64-67
34106774-4	2021	The newly developed Genii ostomy appliances (Trio Healthcare) use novel Sil2 Breathable Silicone Technology to provide secure, effective adhesion and manage moisture levels by replicating natural transepidermal water loss (TEWL).	Water	211-216	trio Rho guanine nucleotide exchange factor	Homo sapiens	45-49
34168809-4	2021	Unlike the case in conventional aqueous electrolytes featuring typical Zn(H2O)6 2+ solvation, a solvation sheath of Zn2+ with the co-participation of the DMC solvent and OTf- anion is found in the formulated H2O + DMC electrolyte, which contributes to the formation of a robust ZnF2 and ZnCO3-rich interphase on Zn.	Water	74-77	zinc finger protein 2	Homo sapiens	278-282
34168809-4	2021	Unlike the case in conventional aqueous electrolytes featuring typical Zn(H2O)6 2+ solvation, a solvation sheath of Zn2+ with the co-participation of the DMC solvent and OTf- anion is found in the formulated H2O + DMC electrolyte, which contributes to the formation of a robust ZnF2 and ZnCO3-rich interphase on Zn.	Water	208-211	zinc finger protein 2	Homo sapiens	278-282
35367227-0	2022	Highly efficient surface sequestration of Pb2+ and Cr3+ from water using a Mn3O4 anchored reduced graphene oxide: Selective removal of Pb2+ from real water.	Water	61-66	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	51-54
35367227-1	2022	Owing to the ubiquitous existence of detrimental heavy metals in the environment, simple adsorption-oriented approaches are becoming increasingly appealing for the effective removal of Pb2+ and Cr3+ from water bodies.	Water	204-209	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	194-197
35034269-1	2022	The thermal mineral water of Penon de los Banos spa (Mexico City) has been used for over 500 years starting in pre-Hispanic times and is famous for the treatment of various pathologies.	Water	20-25	surfactant protein A1	Homo sapiens	48-51
35390659-8	2022	Based on the quantification of nonlinearity, we clustered all the samples of water quality responses using K-Means, an unsupervised Machine Learning algorithm, to find the potential types of nonlinear water quality responses for TN (total nitrogen), TP (total phosphorus), and Chla (chlorophyll a).	Water	77-82	C-type lectin domain family 3 member B	Homo sapiens	229-231
35390659-8	2022	Based on the quantification of nonlinearity, we clustered all the samples of water quality responses using K-Means, an unsupervised Machine Learning algorithm, to find the potential types of nonlinear water quality responses for TN (total nitrogen), TP (total phosphorus), and Chla (chlorophyll a).	Water	201-206	C-type lectin domain family 3 member B	Homo sapiens	229-231
35390659-11	2022	Representative nonlinear water quality responses include disproportional improvement, peak change (disappear, move forwards or afterward), and seasonal deterioration of TN after load reduction.	Water	25-30	C-type lectin domain family 3 member B	Homo sapiens	169-171
35583118-7	2022	The spatial distribution function of the solvent revealed the presence of hydrogen bonds bridged by water molecules on the RBD-ACE2 interface.	Water	100-105	angiotensin converting enzyme 2	Homo sapiens	127-131
35248853-1	2022	Rapidly and accurately detect the total nitrogen (TN) concentration is enormously important for surface water protection considering the critical role it plays in reflecting the eutrophication of surface water.	Water	104-109	C-type lectin domain family 3 member B	Homo sapiens	50-52
35248853-1	2022	Rapidly and accurately detect the total nitrogen (TN) concentration is enormously important for surface water protection considering the critical role it plays in reflecting the eutrophication of surface water.	Water	204-209	C-type lectin domain family 3 member B	Homo sapiens	50-52
35042110-4	2022	Moreover, oxidation (especially 20 mM H2O2) decreased the final (90  C) elasticity index (EI) and water holding capacity of TGase-treated actomyosin gel, while TSPP intensified those of TGase-catalyzed actomyosin gel, indicating that TSPP had a positive effect on ameliorating the oxidative stress to TGase-catalyzed gelation of actomyosin.	Water	98-103	transglutaminase 1	Homo sapiens	124-129
35124499-1	2022	In this study, a layered ammonium vanadate (NH4V4O10) nanobelt adsorbent was synthesized by a facile hydrothermal method to remove Sr2+ and Cs+ from contaminated water.	Water	162-167	citrate synthase	Homo sapiens	140-142
35367668-0	2022	Fibroblast Growth Factor 19 stimulates water intake.	Water	39-44	fibroblast growth factor 19	Homo sapiens	0-27
35583822-1	2022	The Dixon method for fat/water separation is widely used to obtain uniform fat suppression using the water-only reconstruction.	Water	25-30	FAT atypical cadherin 1	Homo sapiens	75-78
35583822-1	2022	The Dixon method for fat/water separation is widely used to obtain uniform fat suppression using the water-only reconstruction.	Water	101-106	FAT atypical cadherin 1	Homo sapiens	21-24
35583822-1	2022	The Dixon method for fat/water separation is widely used to obtain uniform fat suppression using the water-only reconstruction.	Water	101-106	FAT atypical cadherin 1	Homo sapiens	75-78
35152107-6	2022	SNS@Fe-PSC could be applied to remove oil from water effectively.	Water	47-52	PSC	Homo sapiens	7-10
35218809-4	2022	Then the MSN-SF/CS microspheres were sprayed on the silk fibroin (SF)/polycaprolactone (PCL)-polyvinyl alcohol (PVA) unidirectional water-conducting composite nanofiber membrane.	Water	132-137	citrate synthase	Homo sapiens	9-18
35562544-3	2022	Soda lakes are natural environments rich in carbonate and bicarbonate water, resulting in elevated pH and salinities that frequently approach saturation.	Water	70-75	phenylalanine hydroxylase	Homo sapiens	99-101
35477296-0	2022	Structure and Orientation of the SARS-Coronavirus-2 Spike Protein at Air-Water Interfaces.	Water	73-78	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	52-57
35477296-4	2022	We here report on the secondary structure and orientation of the S1 segment of the spike protein, which is often used as a model protein for in vitro studies of SARS-CoV-2, at the air-water interface using surface-sensitive vibrational sum-frequency generation (SFG) spectroscopy.	Water	184-189	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	83-88
35477296-6	2022	The SFG experiments show that the S1 segment of the spike protein remains folded at the air-water interface and predominantly binds in its monomeric state, while the combination of small-angle X-ray scattering and two-dimensional infrared spectroscopy measurements indicate that it forms hexamers with the same secondary structure in aqueous solution.	Water	92-97	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	52-57
35007589-7	2022	The immobilized colloids can be more easily released by alkaline DI-water (pH 11.0) than acidic one (pH 6.0) as a result of the more negative surface charges of the immobilized bentonite colloids.	Water	68-73	phenylalanine hydroxylase	Homo sapiens	75-77
35066031-0	2022	Ecological and AhR-mediated risk assessment of polycyclic aromatic hydrocarbons and polybrominated diphenyl ethers on multiple aquatic species in river water: A combined chemical analysis and in silico approach.	Water	152-157	aryl hydrocarbon receptor	Homo sapiens	15-18
35066031-2	2022	In this manuscript, the ecological and AhR-mediated risk of sixteen polycyclic aromatic hydrocarbons (PAHs) and six polybrominated diphenyl ethers (PBDEs) in surface water of Dongjiang River, Southern China was evaluated using chemical analysis and in silico approaches.	Water	166-171	aryl hydrocarbon receptor	Homo sapiens	39-42
35066031-8	2022	This study is the first attempt to assess AhR-mediated risk of river water in multiple aquatic organisms.	Water	69-74	aryl hydrocarbon receptor	Homo sapiens	42-45
35605542-0	2022	Temporal and spatial expression of aquaporins 1, 5, 8, and 9: Potential transport of water across the endometrium and chorioallantois of pigs.	Water	85-90	aquaporin-1	Sus scrofa	35-60
35605542-13	2022	DISCUSSION: Results reveal pigs can potentially use AQP1, AQP5, AQP8, and AQP9 to transport water from the endometrial bloodstream to the allantoic bloodstream or allantoic fluid.	Water	92-97	aquaporin-1	Sus scrofa	52-56
35605542-13	2022	DISCUSSION: Results reveal pigs can potentially use AQP1, AQP5, AQP8, and AQP9 to transport water from the endometrial bloodstream to the allantoic bloodstream or allantoic fluid.	Water	92-97	aquaporin 5	Sus scrofa	58-62
35283198-7	2022	Results show that the proposed forecast model provides highly accurate forecast result for all of the six water quality data: the average of MAPE of the forecast results for the six water quality datasets is 4.59% for 7 day ahead prediction.	Water	182-187	PRAME nuclear receptor transcriptional regulator	Homo sapiens	141-145
35612874-1	2022	We present here a novel strategy based on the covalent grafting of a C-functionalized Ni-cyclam complex onto glassy carbon to achieve heterogeneous electrocatalytic CO2 reduction in neutral water at low overpotential (-500 mV vs. NHE), with moderate turnover number (TON = 454), high selectivity (85% CO produced) and good faradaic efficiency (56% CO).	Water	190-195	solute carrier family 9 member C1	Homo sapiens	230-233
35435328-5	2022	Cationic MTem/Los improve ocular retention of conjugated water-soluble Tem and loaded water-insoluble Los via electrostatic interaction with negatively charged mucin on the cornea, enabling an increase in therapeutic efficiency and a decrease in dosing frequency.	Water	57-62	LOC100508689	Homo sapiens	160-165
35435328-5	2022	Cationic MTem/Los improve ocular retention of conjugated water-soluble Tem and loaded water-insoluble Los via electrostatic interaction with negatively charged mucin on the cornea, enabling an increase in therapeutic efficiency and a decrease in dosing frequency.	Water	86-91	LOC100508689	Homo sapiens	160-165
16411935-1	2006	Variation in the C18OO content of atmospheric CO2 (delta18Oa) can be used to distinguish photosynthesis from soil respiration, which is based on carbonic anhydrase (CA)-catalyzed 18O exchange between CO2 and 18O-enriched leaf water (delta18Ow).	Water	226-231	carbonic anhydrase	Zea mays	145-163
35384089-5	2022	Such superior performance could be attributed to the n-type semiconducting character of Ag 2 S to receive electrons from water molecules at low humidity, and its highly hydrophilic surface to absorb more water molecules at higher humidity to enable the formation of ion-conductive paths.	Water	121-126	angiotensin II receptor type 1	Homo sapiens	88-94
35384089-5	2022	Such superior performance could be attributed to the n-type semiconducting character of Ag 2 S to receive electrons from water molecules at low humidity, and its highly hydrophilic surface to absorb more water molecules at higher humidity to enable the formation of ion-conductive paths.	Water	204-209	angiotensin II receptor type 1	Homo sapiens	88-94
35600977-6	2023	Meanwhile, coupling TPBP with AIE properties to the hydrophobic chain segment of the carrier not only improved its water solubility and reduced its cytotoxicity, but also significantly enhanced its imaging performance in an aqueous phase.	Water	115-120	trophoblast specific protein alpha	Mus musculus	20-24
35304594-3	2022	Cyclooxygenase 2 (COX2) is specifically expressed in the renal medulla and contributes to the maintenance of the electrolyte/water balance in the body.	Water	125-130	prostaglandin-endoperoxide synthase 2	Mus musculus	0-16
35304594-3	2022	Cyclooxygenase 2 (COX2) is specifically expressed in the renal medulla and contributes to the maintenance of the electrolyte/water balance in the body.	Water	125-130	prostaglandin-endoperoxide synthase 2	Mus musculus	18-22
16784193-6	2006	The reduction time of PrPsc in water was equal to or longer than the PrPsc reduction time in anaerobic sludge.	Water	31-36	prion protein	Mus musculus	22-27
35245523-7	2022	Angiotensin II further increased the expression and activity of the NKA in both genotypes along with the water channel, aquaporin 1 (Aqp1).	Water	105-110	aquaporin 1	Mus musculus	133-137
35072953-8	2022	Nevertheless, significant reservoir-wide trends (increasing TP, phytoplankton chla, TOC) and mid- and/or lower region trends (increasing TN, tNH3 , decreasing TN:TP ratios) suggest that water quality degradation from eutrophication has worsened over time.	Water	186-191	C-type lectin domain family 3 member B	Homo sapiens	137-139
35072953-8	2022	Nevertheless, significant reservoir-wide trends (increasing TP, phytoplankton chla, TOC) and mid- and/or lower region trends (increasing TN, tNH3 , decreasing TN:TP ratios) suggest that water quality degradation from eutrophication has worsened over time.	Water	186-191	C-type lectin domain family 3 member B	Homo sapiens	159-161
16303677-8	2005	Total mucin and MUC5AC mucin secretions only increased following pure water treatment, while MUC5B mucin secretion increased with pure water, hypo- and hypertonic saline treatment.	Water	135-140	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	93-98
35358878-1	2022	A proper pH environment is essential for a wide variety of industries and applications especially related to water treatment.	Water	109-114	phenylalanine hydroxylase	Homo sapiens	9-11
35367940-11	2022	However, imbalanced changes in TN and TP after management intervention may weaken the top-down control of zooplankton on phytoplankton and slow down water clarity improvement.	Water	149-154	C-type lectin domain family 3 member B	Homo sapiens	31-33
35149100-3	2022	In this work, chitosan/polyvinylpyrrolidone/zein (CS/PVP/Zein) sponges with macroporous structure were prepared, which exhibited rapid water absorption capacity and water-triggered expanding property with low cytotoxicity and low hemolysis ratio.	Water	135-140	citrate synthase	Rattus norvegicus	50-61
35149100-3	2022	In this work, chitosan/polyvinylpyrrolidone/zein (CS/PVP/Zein) sponges with macroporous structure were prepared, which exhibited rapid water absorption capacity and water-triggered expanding property with low cytotoxicity and low hemolysis ratio.	Water	165-170	citrate synthase	Rattus norvegicus	50-61
15998844-5	2005	Although AQP7 solo-knockout mice did not exhibit a urinary concentrating defect, AQP1/AQP7 double-knockout mice had a reduction in urinary concentrating ability compared with AQP1 solo-knockout mice, suggesting that the amount of water reabsorbed through AQP7 in the proximal straight tubules is physiologically substantial.	Water	230-235	aquaporin 1	Mus musculus	81-85
35621307-2	2022	To validate the workflow and highlight its capabilities, hybrid Monte Carlo/molecular dynamics (MC/MD) simulations are performed for SPC/E water in the isobaric-isothermal (NPT) and grand canonical (GC) ensembles as well as with Gibbs ensemble Monte Carlo (GEMC).	Water	139-144	surfactant protein C	Bos taurus	133-136
16199493-5	2005	In the complex of the coumarin-containing oligonucleotide and the noncatalytic APE1, the dye"s absorption spectrum is shifted relative to its spectrum in either water or within the unbound oligonucleotide.	Water	161-166	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	79-83
35627061-1	2022	Phyllanthus emblica L. fruits were extracted by a hot water assistant with ultrasonication to obtain aqueous Phyllanthus emblica L. extract (APE).	Water	54-59	apurinic/apyrimidinic endonuclease 1	Mus musculus	141-144
35627036-7	2022	In addition, the results of an animal test of diabetes mellitus II (DM II) with ACP showed that the total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and fasting blood glucose and water in the serum of mice with ACP were significantly lower than those in the model group; the serum SOD, hepatic glycogen, and insulin of mice added with ACP were significantly higher than those in the model group.	Water	218-223	vitamin A enhanced cleft palate	Mus musculus	80-83
35472010-8	2022	There were positive univariate relationships between water extractable soil P and annual EOF-water concentrations and yields of orthophosphate, TP, TN, and SS (p < 0.01).	Water	53-58	C-type lectin domain family 3 member B	Homo sapiens	148-150
35472010-8	2022	There were positive univariate relationships between water extractable soil P and annual EOF-water concentrations and yields of orthophosphate, TP, TN, and SS (p < 0.01).	Water	93-98	C-type lectin domain family 3 member B	Homo sapiens	148-150
16275913-10	2005	The effects of WNK3 on these transporters and their coexpression in renal epithelia implicate WNK3 in NaCl, water, and blood pressure homeostasis, perhaps via signaling downstream of vasopressin.	Water	108-113	arginine vasopressin S homeolog	Xenopus laevis	183-194
35467350-8	2022	Ligand 2 is diving into the GRPR transmembrane (TM) helical cavity, thereby forming hydrogen bonds through its amidated end, water-mediated hydrogen bonds, and pi-pi interactions.	Water	125-130	gastrin releasing peptide receptor	Mus musculus	28-32
35586132-6	2022	The high value area for CS was concentrated mainly in forest land, water body and grassland, whereas the low value area was concentrated mainly in construction land.	Water	67-72	citrate synthase	Homo sapiens	24-26
16268581-5	2005	Addition of ethanol, water, or pyrrole converts {[(H)OCPH]H3]2+ into [(H,EtO)OCPH]H2, [(H,OH)OCPH]H2, or pyrrole appended O-confused porphyrin [(H,pyrrole)OCPH]H2, respectively.	Water	21-26	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	73-76
35617855-1	2022	Herein, we report the discovery process and antitumor activity of the TRK inhibitor CZw-124 (8o), which is a quinazoline derivative.	Water	93-95	neurotrophic receptor tyrosine kinase 1	Homo sapiens	70-73
35629831-8	2022	Salt rejection was higher for BiOCl/Bi2O3, while water permeability was higher for BiOCl/Ag2S.	Water	49-54	angiotensin II receptor type 1	Homo sapiens	89-93
35467776-1	2022	To describe transverse relaxation of water in fixed tissue we propose a model transverse relaxation accelerated by diffusion and exchange (TRADE) that assumes exchange between free (visible) and bound (invisible) water, which relax by the dipole-dipole interaction, chemical exchange, and translation in the field gradient.	Water	37-42	tumor necrosis factor receptor superfamily, member 19	Mus musculus	139-144
35467776-1	2022	To describe transverse relaxation of water in fixed tissue we propose a model transverse relaxation accelerated by diffusion and exchange (TRADE) that assumes exchange between free (visible) and bound (invisible) water, which relax by the dipole-dipole interaction, chemical exchange, and translation in the field gradient.	Water	213-218	tumor necrosis factor receptor superfamily, member 19	Mus musculus	139-144
16242116-1	2005	Prior studies suggest that the hydrophobic surfactant proteins, SP-B and SP-C, promote adsorption of the lipids in pulmonary surfactant to an air-water interface by stabilizing a negatively curved rate-limiting structure that is intermediate between bilayer vesicles and the surface film.	Water	146-151	surfactant protein B	Homo sapiens	64-68
35489242-6	2022	Specifically, the cotton fibers supported a certain amount of water by successfully pulling-pushing 1 mL of water and 1 mL of HEX in/out twice, respectively.	Water	62-67	hematopoietically expressed homeobox	Homo sapiens	126-129
35481354-1	2022	Synthesis and structural depiction of two new metal-organic frameworks (MOFs), namely, ({Zn(L)(oba)} 4H2O)alpha (Zn-MOF-1) and ({Cd1/2(L)1/2(nipa)1/2(H2O)1/2} (DMF)1/2(H2O))alpha (Cd-MOF-2) (where L = N2,N6-di(pyridin-4-yl)naphthalene-2,6-dicarboxamide, 4,4"-H2oba = 4,4"-oxybisbenzoic acid, and 5-H2nipa = 5-nitroisophthalic acid) are reported.	Water	150-153	CD1c molecule	Homo sapiens	129-149
35332909-7	2022	Silicones modified with SMAs having longer tethers (m = 13 and 30) underwent rapid and substantial water-driven restructuring of PEO to the surface to form highly hydrophilic surfaces, especially as SMA concentration increased.	Water	99-104	survival of motor neuron 1, telomeric	Homo sapiens	199-202
16262240-8	2005	In the sequestered form, the U37 base packs against G36, and its 2"-hydroxyl group forms a water mediated hydrogen bond to O4" of G+1.	Water	91-96	small nucleolar RNA, C/D box 3 pseudogene 3	Homo sapiens	29-32
35540800-3	2022	This concentration in complete feed would correspond to maximum concentrations in water of 600 mg GAA/L for chickens for fattening, piglets and pigs for fattening.	Water	82-87	alpha glucosidase 2	Gallus gallus	98-101
16262324-5	2005	Pure water flux for [PSS/PAH](3)PSS-coated membranes at 4.8 bar is 1.6 m(3)/(m(2)day), which is more than 2-fold higher than that through a commercial 500 Da membrane.	Water	5-10	phenylalanine hydroxylase	Homo sapiens	25-28
35152755-5	2022	As a model system for a non-transparent food colloid such as mayonnaise, we designed an oil-in-water emulsion containing the ferric ion binding protein phosvitin commonly present in egg yolk.	Water	95-100	casein kinase 2 beta	Homo sapiens	152-161
16505760-14	2005	CONCLUSION: We demonstrated a significant correlation between fat/water ratio and histological findings for the detection and grading of fatty liver.	Water	66-71	FAT atypical cadherin 1	Homo sapiens	62-65
35131618-1	2022	The effect of water, confinement and confined water on the proton transfer of 3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazole (bis-HPTA) was investigated.	Water	14-19	hepatocyte growth factor	Homo sapiens	126-130
35131618-1	2022	The effect of water, confinement and confined water on the proton transfer of 3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazole (bis-HPTA) was investigated.	Water	46-51	hepatocyte growth factor	Homo sapiens	126-130
35151170-9	2022	The micro-chip showed great potential as a fast detection tool for the monitoring of Cr3+ and Al3+ ions in real samples such as river water samples.	Water	134-139	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	85-88
16363234-8	2005	A molecular dynamics simulation of Gla 25--&gt;Lys/EPCR complex in water suggested that the affinity between the molecules was decreased compared to the wild type Gla domain/EPCR complex.	Water	67-72	protein C receptor	Homo sapiens	51-55
35076837-8	2022	Additionally, the economic feasibility showed that the use of copper trays incorporated with reflective mirrors (HSD-CT&RM) is a very effective option as it reduces the cost of distilled water by 44.1%.	Water	187-192	carbohydrate sulfotransferase 3	Homo sapiens	113-116
35571333-1	2022	The chemical structure of GLP-1, a novel water-soluble heteropolysaccharide purified Ganoderma leucocontextum fruiting bodies, has been characterized in our previous study.	Water	41-46	glucagon	Mus musculus	26-31
16363234-8	2005	A molecular dynamics simulation of Gla 25--&gt;Lys/EPCR complex in water suggested that the affinity between the molecules was decreased compared to the wild type Gla domain/EPCR complex.	Water	67-72	protein C receptor	Homo sapiens	174-178
16381156-0	2005	Presence of Aeromonas spp in water from drinking-water- and wastewater-treatment plants in Mexico City.	Water	29-34	histocompatibility minor 13	Homo sapiens	22-25
35478184-6	2022	Through AFM investigation, the reaction of hair cuticles with chlorine water has further strengthened the idea that the Allworden membrane does not exist, and is actually an artefact of the delamination of the A-layer and exocuticle from the underlying endocuticle.	Water	71-76	afamin	Homo sapiens	8-11
16381156-0	2005	Presence of Aeromonas spp in water from drinking-water- and wastewater-treatment plants in Mexico City.	Water	49-54	histocompatibility minor 13	Homo sapiens	22-25
16354009-2	2005	Insulin-loaded PLGA microspheres were prepared by water-in-oil-in-water double emulsion (batch A) and solid-in-oil-in-water emulsion (batch B) methods.	Water	66-71	insulin	Oryctolagus cuniculus	0-7
35571793-3	2022	Thus, the current work reports the effect of using a mixed-ligand strategy on the MOF framework and its effect on the removal of copper ions from water by adding terephthalic acid (BDC) linker to the ZIF-8precursors (2-methylimidazole (mI) and Zn2+) under solvothermal synthesis, leading to the formation of a hierarchical microporous mesoporous MOF, named Zn-mI-BDC, which was characterized by SEM, EDX, XRD, TGA, BET, and FTIR.	Water	146-151	T-box transcription factor 1	Homo sapiens	410-413
16186376-1	2005	PURPOSE: In adult retina, aquaporin-4 (AQP4) and inwardly rectifying K(+) (Kir4.1) channels localize to astrocyte and Muller cell membranes facing vascular and vitreous compartments, optimizing clearance of extracellular K(+) and water from the synaptic layers.	Water	230-235	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	75-81
35571793-3	2022	Thus, the current work reports the effect of using a mixed-ligand strategy on the MOF framework and its effect on the removal of copper ions from water by adding terephthalic acid (BDC) linker to the ZIF-8precursors (2-methylimidazole (mI) and Zn2+) under solvothermal synthesis, leading to the formation of a hierarchical microporous mesoporous MOF, named Zn-mI-BDC, which was characterized by SEM, EDX, XRD, TGA, BET, and FTIR.	Water	146-151	delta/notch like EGF repeat containing	Homo sapiens	415-418
16186376-12	2005	The transitory coexpression of AQP4 and Kir4.1 proteins by differentiating horizontal interneurons suggests that these cells mediate K(+) and water transcellular uptake until the initiation of phototransduction, when glial cells assume these functions.	Water	142-147	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	40-46
35413082-7	2022	Logistic regression models were used to analyze the risk of illness as a function of fecal contamination in water as measured by Enterococcus spp.	Water	108-113	histocompatibility minor 13	Homo sapiens	142-145
16142959-2	2005	ATR/MIR in situ showed that the accumulation of PPA molecules near the GaAs surface increased with the water concentration in the solution.	Water	103-108	MLX interacting protein	Homo sapiens	4-7
35409344-1	2022	The angiotensin II (Ang II) type 1 receptor (AT1R) is involved in the regulation of blood pressure (through vasoconstriction) and water and ion homeostasis (mediated by interaction with the endogenous agonist).	Water	130-135	angiotensin II receptor type 1	Homo sapiens	4-43
35409344-1	2022	The angiotensin II (Ang II) type 1 receptor (AT1R) is involved in the regulation of blood pressure (through vasoconstriction) and water and ion homeostasis (mediated by interaction with the endogenous agonist).	Water	130-135	angiotensin II receptor type 1	Homo sapiens	45-49
16128588-2	2005	It has been shown that the first elementary reaction of this process, (E-SeH) + H(2)O(2) --&gt; (E-SeOH) + H(2)O (1), proceeds via a stepwise pathway with the overall barrier of 17.1 kcal/mol, which is in good agreement with the experimental barrier of 14.9 kcal/mol.	Water	80-85	epoxide hydrolase 2	Homo sapiens	73-76
35475886-8	2022	The oxidative stress (H2O2) induced on human corneal endothelial cells, which repressed miR-34a/b expression, may account for the impaired signaling cascade to mitochondrial metabolic homeostasis necessary for an efficient water efflux from the corneal stroma.	Water	223-228	microRNA 34a	Homo sapiens	88-97
15814138-4	2005	Water contact angles for these PAAm-grafted TCPS surfaces were less than 10 degrees (costheta = 0.99) with PAAm grafted amounts of 1.6 microg/cm(2) as determined by ATR/FT-IR.	Water	0-5	ATR serine/threonine kinase	Bos taurus	165-168
35529088-1	2022	Aldosterone controls salt-water homeostasis by acting on the mineralocorticoid receptor (MR), a ligand-activated transcription factor, in kidney epithelial cells.	Water	26-31	nuclear receptor subfamily 3 group C member 2	Homo sapiens	61-87
16104840-4	2005	Several lines of evidence suggest that AQP1 (aquaporin-1) is the ultrasmall pore responsible for transcellular water permeability during PD.	Water	111-116	aquaporin 1	Rattus norvegicus	39-43
35529088-1	2022	Aldosterone controls salt-water homeostasis by acting on the mineralocorticoid receptor (MR), a ligand-activated transcription factor, in kidney epithelial cells.	Water	26-31	nuclear receptor subfamily 3 group C member 2	Homo sapiens	89-91
16104840-4	2005	Several lines of evidence suggest that AQP1 (aquaporin-1) is the ultrasmall pore responsible for transcellular water permeability during PD.	Water	111-116	aquaporin 1	Rattus norvegicus	45-56
34998778-9	2022	This paper uncovers the combined efforts required of service providers, service authorities, international donors, and local aid actors to ensure the sustainable maintenance of rural water infrastructure for reliable safe water access.	Water	183-188	activation induced cytidine deaminase	Homo sapiens	125-128
16104840-6	2005	Studies in knockout mice provided further evidence that osmotically driven water transport across the PM is mediated by AQP1.	Water	75-80	aquaporin 1	Mus musculus	120-124
34998778-9	2022	This paper uncovers the combined efforts required of service providers, service authorities, international donors, and local aid actors to ensure the sustainable maintenance of rural water infrastructure for reliable safe water access.	Water	222-227	activation induced cytidine deaminase	Homo sapiens	125-128
16104840-10	2005	The results also emphasize the critical role of AQP1 during PD and suggest that manipulation of AQP1 expression may be used to increase water permeability across the PM.	Water	136-141	aquaporin 1	Rattus norvegicus	96-100
16153114-6	2005	Water contact angle measurement and water swelling analysis revealed that both surface hydrophilicity and bulk hydrophilicity of the poly(ester urethane)s were enhanced by incorporating the PEG segment into PHB polymer chains.	Water	0-5	prohibitin 1	Homo sapiens	207-210
35457840-0	2022	Effect of Wetting Characteristics of Polishing Fluid on the Quality of Water-Dissolution Polishing of KDP Crystals.	Water	71-76	WNK lysine deficient protein kinase 1	Homo sapiens	102-105
35457840-2	2022	However, KDP crystals are difficult to produce because of their inherent softness, brittleness, water-solubility, and temperature sensitivity.	Water	96-101	WNK lysine deficient protein kinase 1	Homo sapiens	9-12
35457840-3	2022	The authors" group developed a water-dissolution polishing method in previous studies to obtain near-damage-free KDP surfaces.	Water	31-36	WNK lysine deficient protein kinase 1	Homo sapiens	113-116
16076766-10	2005	Immunoblotting of uteri from rats treated with water extracts of adlay seeds demonstrated an induction of cyclooxygenase-2 (COX-2) protein expression.	Water	47-52	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	106-122
35349055-12	2022	Furthermore, multiple linear regression (MLR) model and multilayer perceptron neural networks (MLP-NN) were used for the estimation and prediction of the water quality indices.	Water	154-159	cysteine and glycine rich protein 3	Homo sapiens	95-98
35275632-4	2022	Kinetic investigations reveal that H-atom transfer to the metal oxide surface occurs through concerted proton-electron transfer, resulting in the formation of a transient VIII-OH2 moiety that, upon displacement of the water ligand with an acetonitrile molecule, forms the oxygen-deficient polyoxovanadate-alkoxide cluster.	Water	218-223	cytochrome c oxidase subunit 8A	Homo sapiens	171-175
16076766-10	2005	Immunoblotting of uteri from rats treated with water extracts of adlay seeds demonstrated an induction of cyclooxygenase-2 (COX-2) protein expression.	Water	47-52	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	124-129
16076766-11	2005	The water extracts of adlay seeds also enhanced extracellular signal-regulated protein kinase (ERK) 1/2 phosphorylation and protein kinase C (PKC)-alpha translocation from cytosolic to particulate fractions in uteri.	Water	4-9	mitogen activated protein kinase 3	Rattus norvegicus	48-103
16043061-5	2005	The PCA1 and PCA2 are related with the water (or ethanol) content of the sample, whereas the PCA3 is related with the fluorescence background of the Raman spectra.	Water	39-44	prostate cancer associated transcript 1	Homo sapiens	4-8
35254605-1	2022	Mud is a semi-colloidal substance formed by the mixture of inorganic, organic and water under the influence of various physical and chemical factors through geological and biological processes.	Water	82-87	adaptor related protein complex 5 subunit mu 1	Homo sapiens	0-3
35196450-8	2022	In neutral water at room temperature, LnIII-TREN-MAM binds two or three equivalents of fluorinated phosphonates.	Water	11-16	sarcoglycan gamma	Homo sapiens	49-52
15906320-4	2005	At the first stage, a unified motion of Arg789 of GAP, Gln61, Thr35 of Ras, and the lytic water molecule results in a substantial spatial separation of the gamma-phosphate group of GTP from the rest of the molecule (GDP).	Water	90-95	RAS p21 protein activator 1	Homo sapiens	50-53
15964719-9	2005	These results suggest that GmTDF-5 might be a novel cytosolic leucine-zipper-like protein functioning in mature organs of soybean shoot against water-potential changes.	Water	144-149	uncharacterized protein LOC732564	Glycine max	27-34
16087714-4	2005	Here we show that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier.	Water	63-68	dystroglycan 1	Homo sapiens	97-109
15918672-1	2005	Molecular dynamics simulations of the complex formed between the HMG box of the lymphoid enhancer-binding factor (LEF-1) and its cognate DNA duplex were carried out with explicit inclusion of water.	Water	192-197	lymphoid enhancer binding factor 1	Homo sapiens	114-119
35068225-3	2022	Recent studies revealed that SPX acts as a multifunctional peptide in various metabolic processes such as body weight, food intake, energy balance, glucose and lipid metabolism, lipid storage, salt-water balance, and arterial blood pressure.	Water	198-203	spexin hormone	Homo sapiens	29-32
15918672-4	2005	Quite unexpectedly, the simulation indicated that a binding pocket for a specific water molecule may be reversibly formed at the apex of the bend induced in the DNA helix by LEF-1 binding, where a methionine side chain intercalates between two destacked adenines.	Water	82-87	lymphoid enhancer binding factor 1	Homo sapiens	174-179
35103830-1	2022	KEY POINTS:   In patients with acute ischemic stroke, automated measurements of net water uptake in baseline CTA an NCCT scans can be used as predictor for developing malignant cerebral edema.	Water	84-89	solute carrier family 12 member 3	Homo sapiens	116-120
15976003-13	2005	In summary, these findings demonstrate that the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the HPS/aBS model.	Water	186-191	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	113-116
35193744-0	2022	Overexpression of ZmPCK2, a phosphoenolpyruvate carboxykinase gene from maize confers enhanced tolerance to water deficit stress in rice.	Water	108-113	phosphoenolpyruvate carboxykinase homolog 2	Zea mays	18-24
35193744-3	2022	In this study, we found that overexpression of ZmPCK2 significantly enhanced the water-deficit tolerance of transgenic rice.	Water	81-86	phosphoenolpyruvate carboxykinase homolog 2	Zea mays	47-53
16258842-4	2005	The water soluble 24(S)-hydroxysterol is the product of the CYP46A1, and elevated plasma and cerebrospinal fluid hydroxysterol concentrations have been found in AD, reflecting increased brain cholesterol turnover or cellular degradation, due to the neurodegenerative process.	Water	4-9	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	60-67
35193744-5	2022	Overexpression of ZmPCK2 in rice increased stomatal closure and water saving by regulating malate metabolism under water-deficit conditions.	Water	64-69	phosphoenolpyruvate carboxykinase homolog 2	Zea mays	18-24
35193744-5	2022	Overexpression of ZmPCK2 in rice increased stomatal closure and water saving by regulating malate metabolism under water-deficit conditions.	Water	115-120	phosphoenolpyruvate carboxykinase homolog 2	Zea mays	18-24
35193744-8	2022	Taken together, we suggest that ZmPCK2 plays multiple roles in response to water-deficit stress by enhancing ABA signalling pathway, regulating malate metabolism, promoting stomatal closure and further activating the ROS-scavenging system.	Water	75-80	phosphoenolpyruvate carboxykinase homolog 2	Zea mays	32-38
16001453-6	2005	A diffusion model using a solution of Ficks" second law was employed to determine the diffusion coefficient of water into PHG-UV gel as a consequence of adsorption and/or interdiffusion which occur at the PHG-UV gel/mucin solution interface.	Water	111-116	LOC100508689	Homo sapiens	216-221
35352231-2	2022	Here, we report a very efficient method of removing Cr(VI), organic dye, and antibiotic from water using a type-II heterojunction based on Sn3O4/SnS2 solar photocatalyst.	Water	93-98	sodium voltage-gated channel alpha subunit 11	Homo sapiens	145-149
35271280-0	2022	Upcycling Waste Pine nut Shell Membrane for Highly Efficient Separation of Crude Oil-in-Water Emulsion.	Water	88-93	NUT midline carcinoma family member 1	Homo sapiens	21-24
16029183-5	2005	However, changes can occur sooner (or later) if the rate at which mineral-forming ions are delivered to the PRB is higher (or lower) than that expected under typical conditions (i.e., due to higher/lower flow rate or inflowing ground water that has higher/lower ionic strength).	Water	234-239	RB transcriptional corepressor 1	Homo sapiens	108-111
35271280-5	2022	Herein, an underwater superoleophobic pine nut shell membrane (PNSM) was prepared by the simple pumping filtration method, which realized the separation of oil-in-water emulsion and adsorption of dyes and heavy metal ions.	Water	163-168	NUT midline carcinoma family member 1	Homo sapiens	43-46
35371624-4	2022	Each Gly and Bet are replaced, respectively, by ~3 and ~5 water molecules, with the highest rates of depletion being found for Gly around Bet and Gly around Gly.	Water	58-63	delta/notch like EGF repeat containing	Homo sapiens	13-16
15859952-9	2005	CONCLUSIONS: The pattern of subcellular distribution of AQP8 and AQP1 strongly corroborates the hypothesis of a transcellular route for the movement of water across the gall-bladder epithelium.	Water	152-157	aquaporin 1	Mus musculus	65-69
35307994-7	2022	International SpA, Rome, Italy) water in UVB-irradiated immortalized human keratinocytes.	Water	32-37	surfactant protein A1	Homo sapiens	14-17
15859952-10	2005	Osmotic water would cross the apical membrane through AQP8 and AQP1, although AQP1 would be the facilitated pathway for the movement of water across the basolateral membrane.	Water	8-13	aquaporin 1	Mus musculus	63-67
15859952-10	2005	Osmotic water would cross the apical membrane through AQP8 and AQP1, although AQP1 would be the facilitated pathway for the movement of water across the basolateral membrane.	Water	136-141	aquaporin 1	Mus musculus	78-82
15859952-12	2005	It is tempting to hypothesize that AQP1 is hormonally translocated to the gall-bladder apical membrane to secrete water as in the bile duct epithelium, a functional homologue of the gall-bladder epithelium, whereas apical AQP8 may account for the absorption of water from gall-bladder bile.	Water	114-119	aquaporin 1	Mus musculus	35-39
15859952-12	2005	It is tempting to hypothesize that AQP1 is hormonally translocated to the gall-bladder apical membrane to secrete water as in the bile duct epithelium, a functional homologue of the gall-bladder epithelium, whereas apical AQP8 may account for the absorption of water from gall-bladder bile.	Water	261-266	aquaporin 1	Mus musculus	35-39
35200264-9	2022	The most common first aid options for managing burns at home were cold water alone 195 (42%), any sort of cream alone 177 (38%), or both 317 (69%).	Water	71-76	activation induced cytidine deaminase	Homo sapiens	22-25
16890171-5	2005	Elevation and maintenance of increased IAP to 20mmHg for 7 consecutive days was achieved by means of an intraperitonially placed balloon filled with water.	Water	149-154	Cd47 molecule	Rattus norvegicus	39-42
35084406-2	2022	In this work, we propose a two-dimensional CdS/SnS2 heterostructure (CSHS) as a possible water splitting photocatalyst by first-principles calculations.	Water	89-94	sodium voltage-gated channel alpha subunit 11	Homo sapiens	47-51
35084406-6	2022	More encouragingly, the introduction of a S-vacancy into SnS2 could effectively lower the overpotential of the oxygen evolution reaction, thus ensuring the overall water redox reaction to be achieved spontaneously under light irradiation.	Water	164-169	sodium voltage-gated channel alpha subunit 11	Homo sapiens	57-61
15842175-4	2005	In this paper we have proposed a 3D structure of Hoxc8-DNA complex obtained by Homology modeling and molecular dynamics (MD) simulation in explicit water.	Water	148-153	homeobox C8	Homo sapiens	49-54
35043136-2	2022	A Keggin-type polyoxometalate-based metal-organic complex (MOC), (CuII4CuI(H2trz)4(C2O4)(H2O)4(H3PW11.18CuII0.82O40)) 8H2O (1) (H3trz = 1,2,4-triazole), was designed and synthesized under hydrothermal conditions, and was structurally characterized by single crystal X-ray diffraction, PXRD, IR spectroscopy, TGA, and XPS.	Water	89-92	T-box transcription factor 1	Homo sapiens	308-311
15911069-2	2005	The level and activity of this receptor determines the biological effects of ANP and BNP in different tissues mainly directed towards the maintenance of salt and water homeostasis.	Water	162-167	natriuretic peptide B	Homo sapiens	85-88
15840053-7	2005	The expression of the water channel aquaporin-1 (AQP1) and endothelial NO synthase (eNOS) was investigated at the protein (immunoblotting, immunostaining) and mRNA [real-time reverse-transcription-polymerase chain reaction (RT-PCR)] levels.	Water	22-27	aquaporin 1	Mus musculus	49-53
15822986-4	2005	Specifically, a diester cryptand with a pyridyl nitrogen atom located at a site occupied by either water or a PF(6) anion in analogous complexes exhibited the highest association constant K(a) = 5.0 x 10(6) M(-1) in acetone with paraquat, 9000 times greater than the crown ether system.	Water	99-104	sperm associated antigen 17	Homo sapiens	110-115
15799730-6	2005	RESULTS: With the C12 prodrug silicone oil formulation, the concentration of free 5-FU in the vitreous water phase 1 hour after surgery was 3.30 +/- 1.62 microg/ml.	Water	103-108	protegrin-4	Sus scrofa	18-21
15563580-11	2005	Dehydration induced by water deprivation for 2 days caused a tissue-specific decrease in UT-B1 abundance in the urinary bladder and the ureter.	Water	23-28	solute carrier family 14 (urea transporter), member 1	Mus musculus	89-94
15763464-2	2005	Catalase is one of the regulatory enzymes and facilitates the degradation of hydrogen peroxide to oxygen and water.	Water	109-114	catalase	Bombyx mori	0-8
15644319-5	2005	The role of O(2)(-) and related products such as H(2)O(2) in stimulating the expression of protein tyrosine kinase is suggested by the observation that addition of 50-200 microm H(2)O(2) increased the phosphorylation of c-Jun and the expression of c-Src in M1 cells, a mouse collecting duct principal cell line.	Water	49-54	jun proto-oncogene	Mus musculus	220-225
15813278-1	2005	Numerical simulations of radiative transfer were used to examine the effects of a nonuniform vertical profile of the inherent optical properties of the water column associated with the vertical profile of chlorophyll concentration, Chl(z), on the spectral remote-sensing reflectance, Rrs(gamma), of the ocean.	Water	152-157	chordin like 1	Homo sapiens	232-235
35171621-1	2022	This work reports the feasibility of polybutadiene (PB) cross-linking under UV irradiation in the presence of a linear polymer, cellulose acetate (CA), to form semi-interpenetrating polymer networks at the air-water interface.	Water	210-215	capping actin protein of muscle Z-line subunit beta	Homo sapiens	52-54
35171621-1	2022	This work reports the feasibility of polybutadiene (PB) cross-linking under UV irradiation in the presence of a linear polymer, cellulose acetate (CA), to form semi-interpenetrating polymer networks at the air-water interface.	Water	210-215	capping actin protein of muscle Z-line subunit beta	Homo sapiens	147-149
15708367-9	2005	ICL and its product appear to be sensitive to oxidative damage; thus, association of CAT with ICL would afford protection from H(2)O(2).	Water	127-132	isocitrate lyase	Ricinus communis	0-3
15737679-5	2005	Among the tested Oatps/OATPs, rat Oatp1b2, human OATP1B1, human OATP1B3, and human OATP1A2 transported microcystin-LR 2- to 5-fold above water-injected control oocytes.	Water	137-142	solute carrier organic anion transporter family member 1A2	Homo sapiens	83-90
35230468-6	2022	Separately, they learned that one of two auditory stimuli predicts free water (CS + vs CS -).	Water	72-77	citrate synthase	Rattus norvegicus	79-81
35230468-10	2022	RESULTS: Female and male rats showed similar PIT, with CS + but not CS - presentations potentiating water-seeking behaviour.	Water	100-105	citrate synthase	Rattus norvegicus	55-57
35230468-11	2022	LY379268 (1 mg/kg) attenuated CS + evoked increases in both water-associated lever pressing and conditioned approach to the water port.	Water	60-65	citrate synthase	Rattus norvegicus	30-32
35230468-11	2022	LY379268 (1 mg/kg) attenuated CS + evoked increases in both water-associated lever pressing and conditioned approach to the water port.	Water	124-129	citrate synthase	Rattus norvegicus	30-32
15728055-1	2005	GPI 15715 is the first water-soluble propofol prodrug that has been studied in humans.	Water	23-28	glucose-6-phosphate isomerase	Homo sapiens	0-3
35237114-10	2022	The econometric model concluded that the quantity of crop damage was negatively significant in relation to distance from forest and distance from water body while positively significant to distance from settlements and distance from owner"s home.	Water	146-151	LUC7 like 3 pre-mRNA splicing factor	Macaca mulatta	53-57
15787961-1	2005	Water-soluble phospholamban (WSPLB) is a designed, water-soluble analogue of the pentameric membrane protein phospholamban (PLB), which contains the same core and interhelical residues as PLB, with only the solvent-exposed positions mutated.	Water	0-5	phospholamban	Homo sapiens	31-34
35222937-13	2022	Similarly, it was 2.2 times higher (18.5%, OR = 2.2, and p=0.002) in calves drinking river water than in calves drinking tap water.	Water	125-130	tracheal antimicrobial peptide	Bos taurus	121-124
35113112-2	2022	We combined ReaxFF and experiments to investigate the dissolution at the Li1+xAlxTi2-x(PO4)3-water interface.	Water	93-98	transglutaminase 1	Homo sapiens	73-76
15787961-1	2005	Water-soluble phospholamban (WSPLB) is a designed, water-soluble analogue of the pentameric membrane protein phospholamban (PLB), which contains the same core and interhelical residues as PLB, with only the solvent-exposed positions mutated.	Water	0-5	phospholamban	Homo sapiens	124-127
15787961-1	2005	Water-soluble phospholamban (WSPLB) is a designed, water-soluble analogue of the pentameric membrane protein phospholamban (PLB), which contains the same core and interhelical residues as PLB, with only the solvent-exposed positions mutated.	Water	51-56	phospholamban	Homo sapiens	31-34
34999438-6	2022	In the experimental landfill reactors with gas-water joint regulation, the proportion of N2O-N to TN loss ranged from 0.02% to 0.75%.	Water	47-52	C-type lectin domain family 3 member B	Homo sapiens	98-100
15697203-2	2005	We present a microscopic description of the structure and dynamics of PLB in solution and membrane environments, based on 10 ns molecular dynamics simulations of PLB in lipid bilayer and 5 ns simulations in methanol and water, and a water-soluble model of PLB in water.	Water	233-238	phospholamban	Homo sapiens	70-73
35139789-7	2022	Results:CA4 NPs prepared with a low organic/water phase ratio (1:20) and high drug/PLGA mass ratio (1:2.5) exhibited a uniform hydrodynamic particle size of 142 nm; zeta potential of -1.66 mV; and encapsulation efficacy and drug loading of 92.1% and 28.3%, respectively.	Water	44-49	carbonic anhydrase 4	Homo sapiens	8-11
35084406-0	2022	Two-dimensional CdS/SnS2 heterostructure: a highly efficient direct Z-scheme water splitting photocatalyst.	Water	77-82	sodium voltage-gated channel alpha subunit 11	Homo sapiens	20-24
15697203-2	2005	We present a microscopic description of the structure and dynamics of PLB in solution and membrane environments, based on 10 ns molecular dynamics simulations of PLB in lipid bilayer and 5 ns simulations in methanol and water, and a water-soluble model of PLB in water.	Water	233-238	phospholamban	Homo sapiens	70-73
18969861-3	2005	The water regaining capacity of the grafted polymer is studied by TGA measurements and the active participation of the amide moiety towards metal ion complexation has been confirmed by Far IR spectroscopy.	Water	4-9	T-box transcription factor 1	Homo sapiens	66-69
35080892-6	2022	The GaMD US/dual-water approach is tested on the 1D Potential of Mean Force (PMF) of the solvated CD2-CD58 system (168 000 atoms), allowing the AMOEBA PMF to converge within 1 kcal/mol of the experimental value.	Water	17-22	CD58 molecule	Homo sapiens	102-106
15965718-6	2005	PAH mineralization correlated with bottom water DO saturation above 70% (r(2) &gt; 0.99).	Water	42-47	phenylalanine hydroxylase	Homo sapiens	0-3
35073060-3	2022	Water proton T1 relaxation properties were examined in solution and showed significant enhancement in the presence of human serum albumin (HSA).	Water	0-5	albumin	Mus musculus	124-137
35163767-6	2022	Mutations in the AtCRN gene led to the enhancement of salt tolerance by increasing the ability to maintain photosynthetic pigment content and relative water content, while the complemented lines with ectopic expression of OsCRN showed more susceptibility to salt stress detected by photosynthesis performance.	Water	151-156	Protein kinase superfamily protein	Arabidopsis thaliana	17-22
35149422-3	2022	The Carb-NHC-Pd complex behaved as a general surfactant which leads to the formation of a temporary oil-in-water contact interface, thereby promoting the Suzuki-Miyaura reaction.	Water	107-112	syntaxin 8	Homo sapiens	4-8
35018399-2	2022	From previous studies it is known that SnO can be fabricated through a reaction with H2O, which has low oxidizing power.	Water	85-88	strawberry notch homolog 1	Homo sapiens	39-42
35018917-2	2022	Reaction of ZrCl4 with H3pidiox in methanol gives the mononuclear compound (ZrIV(eta1,eta1,eta2-H2pidiox-O,N,O")2(OH2)2)Cl2 H2O CH3OH (1), while the same reaction mixture in the presence of KOH gave the pentanuclear ZrOC (ZrIV5(mu2-OH)4(OH2)4(mu2-eta1,eta1,eta2-Hpidiox-O,N,O")4(eta1,eta1,eta1-HpidioxO,N,O")4) 5KCl 3CH3OH 8H2O (2).	Water	124-127	DNA polymerase iota	Homo sapiens	91-95
35018917-2	2022	Reaction of ZrCl4 with H3pidiox in methanol gives the mononuclear compound (ZrIV(eta1,eta1,eta2-H2pidiox-O,N,O")2(OH2)2)Cl2 H2O CH3OH (1), while the same reaction mixture in the presence of KOH gave the pentanuclear ZrOC (ZrIV5(mu2-OH)4(OH2)4(mu2-eta1,eta1,eta2-Hpidiox-O,N,O")4(eta1,eta1,eta1-HpidioxO,N,O")4) 5KCl 3CH3OH 8H2O (2).	Water	124-127	DNA polymerase iota	Homo sapiens	257-261
34387260-10	2022	Of all IAP measures at both time points, only absolute IAPLIFT at 1 year significantly increased the prevalence of symptom burden (PR, 1.11 (95% CI, 1.05-1.18)) per 10 cm H2O.	Water	171-174	islet amyloid polypeptide	Homo sapiens	7-10
35110760-1	2022	The flow of water in carbon nanochannels has defied understanding thus far1, with accumulating experimental evidence for ultra-low friction, exceptionally high water flow rates and curvature-dependent hydrodynamic slippage2-5.	Water	12-17	fatty acyl-CoA reductase 1	Homo sapiens	71-75
35110760-1	2022	The flow of water in carbon nanochannels has defied understanding thus far1, with accumulating experimental evidence for ultra-low friction, exceptionally high water flow rates and curvature-dependent hydrodynamic slippage2-5.	Water	160-165	fatty acyl-CoA reductase 1	Homo sapiens	71-75
35154285-9	2022	The high expression of TRPC2 and V2R family genes in the accessory olfactory systems of aquatic snakes should enhance their ability to bind water-soluble odor molecules, and thus obtain more information in hydrophytic habitats.	Water	140-145	transient receptor potential cation channel subfamily C member 2 (pseudogene)	Homo sapiens	23-28
35160450-5	2022	Firstly, we investigated albumin dynamics and calculated electrostatic surfaces at experimental pH values in water by using molecular dynamics methods.	Water	109-114	phenylalanine hydroxylase	Homo sapiens	96-98
34985261-1	2022	Anti-fog sprays and solutions are used on eyeglasses to minimize the condensation of water vapor, particularly while wearing a mask.	Water	85-90	zinc finger protein, multitype 1	Mus musculus	5-8
35023666-4	2022	We recently demonstrated that apelin antagonises the hydro-osmotic effect of vasopressin on aquaporin-2 water channel (AQP-2) expression by reducing its mRNA and protein levels in collecting duct principal cells.	Water	104-109	apelin	Mus musculus	30-36
35054857-7	2022	Moreover, it has been reported that a PACAP in water and a 0.9% saline solution at +4  C showed high stability and achieved 80-90% effectiveness after 2 weeks of treatment.	Water	47-52	adenylate cyclase activating polypeptide 1	Homo sapiens	38-43
35071308-8	2021	The results showed that after SBI, LRRK2 and phosphorylated Rab10 (p-Rab10) expression in neuronal cells were upregulated, and administration of PF-06447475 significantly reduced neuronal apoptosis, neuroinflammation, and brain water content 12 h after SBI and improved neurological deficit 72 h after SBI, which is related to the decreased expression of LRRK2 and p-Rab10, and the lessening of lysosomal overload stress.	Water	228-233	RAB10, member RAS oncogene family	Rattus norvegicus	60-65
35071308-8	2021	The results showed that after SBI, LRRK2 and phosphorylated Rab10 (p-Rab10) expression in neuronal cells were upregulated, and administration of PF-06447475 significantly reduced neuronal apoptosis, neuroinflammation, and brain water content 12 h after SBI and improved neurological deficit 72 h after SBI, which is related to the decreased expression of LRRK2 and p-Rab10, and the lessening of lysosomal overload stress.	Water	228-233	RAB10, member RAS oncogene family	Rattus norvegicus	69-74
35072063-12	2021	During PP2, when the COVID-19 lockdown was in place, the proportion of time spent in Z3 doubled, while that spent in Z1 was lowered; the total time spent training on water increased; these changes may have accentuated the improvement in performance during this period.	Water	166-171	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	7-10
34927659-1	2022	Herein, the exquisite combination of coplanar (Tm4(CO2)10(mu3-OH)2(mu2-HCO2)(OH2)2) clusters ({Tm4}) and structure-oriented functional BDCP5- leads to the highly robust nanoporous {Tm4}-organic framework {(Me2NH2)(Tm4(BDCP)2(mu3-OH)2(mu2-HCO2)(H2O)2) 7DMF 5H2O}n (NUC-37, H5BDCP = 2,6-bis(2,4-dicarboxylphenyl)-4-(4-carboxylphenyl)pyridine).	Water	244-247	adaptor related protein complex 1 subunit mu 2	Homo sapiens	67-70
34927659-1	2022	Herein, the exquisite combination of coplanar (Tm4(CO2)10(mu3-OH)2(mu2-HCO2)(OH2)2) clusters ({Tm4}) and structure-oriented functional BDCP5- leads to the highly robust nanoporous {Tm4}-organic framework {(Me2NH2)(Tm4(BDCP)2(mu3-OH)2(mu2-HCO2)(H2O)2) 7DMF 5H2O}n (NUC-37, H5BDCP = 2,6-bis(2,4-dicarboxylphenyl)-4-(4-carboxylphenyl)pyridine).	Water	244-247	adaptor related protein complex 1 subunit mu 2	Homo sapiens	234-237
35008929-4	2022	We concluded that CAM-based therapies have demonstrated benefits for controlling EAU severity with decreases in immune cell migration, especially via ICAM-1/LFA-1 and VCAM-1/VLA-4 (integrin) pathways.	Water	81-84	integrin subunit alpha L	Homo sapiens	157-162
35063208-9	2022	There was an increase in plasma miR-375 expression after 3 h of ingestion of HFHC + orange juice versus water (p = 0.026), and a decrease in plasma miR-205-5p expression after HFHC meal + glucose versus water (p = 0.023).	Water	203-208	microRNA 205	Homo sapiens	148-155
35013905-12	2022	Ad-VSIG4 attenuated NLRP3 levels and inhibited inflammation, as well as improved neurological function and reduced BBB disruption and brain water content.	Water	140-145	V-set and immunoglobulin domain containing 4	Mus musculus	3-8
35099647-9	2022	The comparison demonstrated similarity, only if the same number of parameters were used, but WQI-CETESB gives better water quality, similarly reported for the WQI-NSF, which systematically classify the water quality in the superior range.	Water	202-207	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	163-166
35173627-10	2021	TRPV4 and TRPV1 may have a role in maintenance of cell volume homeostasis as ions and water move through the bilayer.	Water	86-91	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
35173627-10	2021	TRPV4 and TRPV1 may have a role in maintenance of cell volume homeostasis as ions and water move through the bilayer.	Water	86-91	transient receptor potential cation channel subfamily V member 1	Homo sapiens	10-15
35164442-4	2022	Here we show that mice with a tissue specific knockout of insulin receptors in NPY expressing neurons (IRlox/lox; NPYCre/+) display an impaired performance in the probe trial of the Morris Water Maze compared with control mice at both the 6 and the 12, but not at the 24 months time point, consistent with a crucial role of insulin and NPY in cognitive functioning.	Water	189-194	neuropeptide Y	Mus musculus	79-82
35164065-3	2022	Analysis of the three-dimensional reference interaction site model (3DRISM) of SDFT indicates that water mediated interactions in the form of additional water bridges strongly increases the binding between SARS-CoV-2 spike protein and hACE2 compared to SARS-CoV-1-hACE2 complex.	Water	99-104	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	217-222
35164065-3	2022	Analysis of the three-dimensional reference interaction site model (3DRISM) of SDFT indicates that water mediated interactions in the form of additional water bridges strongly increases the binding between SARS-CoV-2 spike protein and hACE2 compared to SARS-CoV-1-hACE2 complex.	Water	99-104	angiotensin converting enzyme 2	Homo sapiens	235-240
35164065-3	2022	Analysis of the three-dimensional reference interaction site model (3DRISM) of SDFT indicates that water mediated interactions in the form of additional water bridges strongly increases the binding between SARS-CoV-2 spike protein and hACE2 compared to SARS-CoV-1-hACE2 complex.	Water	99-104	angiotensin converting enzyme 2	Homo sapiens	264-269
35164065-3	2022	Analysis of the three-dimensional reference interaction site model (3DRISM) of SDFT indicates that water mediated interactions in the form of additional water bridges strongly increases the binding between SARS-CoV-2 spike protein and hACE2 compared to SARS-CoV-1-hACE2 complex.	Water	153-158	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	217-222
35164065-3	2022	Analysis of the three-dimensional reference interaction site model (3DRISM) of SDFT indicates that water mediated interactions in the form of additional water bridges strongly increases the binding between SARS-CoV-2 spike protein and hACE2 compared to SARS-CoV-1-hACE2 complex.	Water	153-158	angiotensin converting enzyme 2	Homo sapiens	235-240
35164065-3	2022	Analysis of the three-dimensional reference interaction site model (3DRISM) of SDFT indicates that water mediated interactions in the form of additional water bridges strongly increases the binding between SARS-CoV-2 spike protein and hACE2 compared to SARS-CoV-1-hACE2 complex.	Water	153-158	angiotensin converting enzyme 2	Homo sapiens	264-269
35164065-6	2022	Further interface analysis has shown that interfacial water promotes and stabilizes the formation of CoV-2/hACE2 complex.	Water	54-59	angiotensin converting enzyme 2	Homo sapiens	107-112
35215095-7	2022	In the facilities where the periodical thermal shock was performed, 16.0% of the results (429 hot water samples collected) were positive for Legionella spp., compared to 21.1% (298 samples), where periodical thermal shock was not performed.	Water	98-103	histocompatibility minor 13	Homo sapiens	152-155
35055067-2	2022	We characterized the mechanism involved in water transport induced by HlyA and analyzed how swelling and hemolysis might be coupled.	Water	43-48	hemolysin transport protein	Escherichia coli	70-74
35425094-1	2021	Water-soluble nanocomposites based on CdSe/ZnS quantum dots (QDs) and hydrophobic tetraphenylporphyrin (TPP) molecules passivated by chitosan (CS) have been formed.	Water	0-5	citrate synthase	Homo sapiens	143-145
15965718-8	2005	Infusion of cooler, well-oxygenated water to the water column overlying contaminated sediments during the summer months may stimulate PAH metabolism preferentially over non-PAH organic matter.	Water	36-41	phenylalanine hydroxylase	Homo sapiens	134-137
15965718-8	2005	Infusion of cooler, well-oxygenated water to the water column overlying contaminated sediments during the summer months may stimulate PAH metabolism preferentially over non-PAH organic matter.	Water	36-41	phenylalanine hydroxylase	Homo sapiens	173-176
15536068-4	2005	We now report that serine racemase catalyzes the degradation of cellular D-serine itself, through the alpha,beta-elimination of water.	Water	128-133	serine racemase	Homo sapiens	19-34
15596131-7	2005	These findings demonstrate that LPS increases cell surface AQP5 expression by changing its subcellular distribution and increases membrane osmotic water permeability through activation of p38 MAP kinase.	Water	147-152	mitogen-activated protein kinase 14	Mus musculus	188-191
15914013-1	2005	Freshly cleaved mica and a mica surface treated with pure water and dilute-salt solution have been investigated by Atomic Force Microscopy (AFM).	Water	58-63	MHC class I polypeptide-related sequence A	Homo sapiens	27-31
15914013-5	2005	The water meniscus between AFM tip and mica surface is considered as the source of this water structure.	Water	4-9	MHC class I polypeptide-related sequence A	Homo sapiens	39-43
15914013-5	2005	The water meniscus between AFM tip and mica surface is considered as the source of this water structure.	Water	88-93	MHC class I polypeptide-related sequence A	Homo sapiens	39-43
15914013-6	2005	On the mica surface treated with pure water and dilute-salt solution, network structures are frequently observed by AFM.	Water	38-43	MHC class I polypeptide-related sequence A	Homo sapiens	7-11
15626512-1	2005	The marine mollusk Aplysia releases the water-borne pheromone attractin during egg laying.	Water	40-45	attractin	Aplysia californica	62-71
15926679-9	2005	The diffusion coefficient of hGH through degraded PLG films was 5.0 x 10(-13) m2/s, which is in the range that could be expected, i.e., several orders of magnitude smaller than its the diffusivity in pure water.	Water	205-210	plasminogen	Homo sapiens	50-53
15926679-12	2005	Although the PLG film contains a large amount of water, a considerable time elapsed before pores of sufficient size formed and diffusion through the film started.	Water	49-54	plasminogen	Homo sapiens	13-16
15595771-8	2004	In addition, comparison to NMR results previously reported allows for conclusions about the mobility of the solvent in the multilayers: the average rotational correlation time of the water molecules in the polyelectrolyte layers decreases upon addition of PSS and increases upon addition of PAH.	Water	183-188	phenylalanine hydroxylase	Homo sapiens	291-294
15530434-1	2004	Aquaporin-1 (AQP1) water channel plays a critical role for water reabsorption in the urinary concentrating mechanism.	Water	19-24	aquaporin 1	Mus musculus	0-11
15530434-1	2004	Aquaporin-1 (AQP1) water channel plays a critical role for water reabsorption in the urinary concentrating mechanism.	Water	19-24	aquaporin 1	Mus musculus	13-17
15530434-1	2004	Aquaporin-1 (AQP1) water channel plays a critical role for water reabsorption in the urinary concentrating mechanism.	Water	59-64	aquaporin 1	Mus musculus	0-11
15530434-1	2004	Aquaporin-1 (AQP1) water channel plays a critical role for water reabsorption in the urinary concentrating mechanism.	Water	59-64	aquaporin 1	Mus musculus	13-17
15563177-2	2004	The oxidation of (6, 5)-enriched nanotubes in water with K(2)Ir(Cl)(6) reveals a valence electron density of 0.2-0.4 e(-)/100 carbon atoms and a reduction potential of approximately 800 mV versus NHE.	Water	46-51	solute carrier family 9 member C1	Homo sapiens	196-199
15663202-1	2004	Fuji ground water improves hypo-activity of liver insulin receptor in Goto-Kakisaki rats.	Water	12-17	insulin receptor	Rattus norvegicus	50-66
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	Water	217-222	lysine acetyltransferase 2B	Homo sapiens	51-54
15537293-2	2004	The feasibility of SPE (solid-phase extraction) and SPME (solid-phase microextraction) for the determination of PAH in drinking water samples has been evaluated.	Water	128-133	phenylalanine hydroxylase	Homo sapiens	112-115
15246975-4	2004	This study tests the hypothesis that prostasin can regulate ENaC in cystic fibrosis epithelia in which excessive Na+ uptake contributes to salt and water imbalance.	Water	148-153	serine protease 8	Homo sapiens	37-46
15488581-3	2004	PAH in organic extracts were analyzed by gas chromatography-mass spectrometry (GC-MS) and 25 individual target PAH summed to get the total PAH concentration in each water sample.	Water	165-170	phenylalanine hydroxylase	Homo sapiens	0-3
15502869-11	2004	H(2)O(2)-induced oxidative stress resulted in the specific oxidation of thiols of proteins involved in detoxification of H(2)O(2) and of enzymes of cofactor and amino acid biosynthesis pathways such as thiolperoxidase, GTP-cyclohydrolase I, and the cobalamin-independent methionine synthase MetE.	Water	0-5	GTP cyclohydrolase 1	Homo sapiens	219-239
15481993-0	2004	New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib.	Water	4-9	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	65-70
15481993-2	2004	The synthesis and pharmacological evaluation of new water-soluble phosphoramidate derivatives of the COX-2 selective inhibitor cimicoxib (4) are described.	Water	52-57	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	101-106
15585109-3	2004	Injection of high-titer lentiviral vectors into the rat striatum resulted in a 7-fold induction of GDNF tissue levels (1060 pg/mg tissue), when doxycycline (a tetracycline analog) was added to the drinking water.	Water	206-211	glial cell derived neurotrophic factor	Rattus norvegicus	99-103
15562942-0	2004	Enamel fluorosis prevalence after a 7-year interruption in water fluoridation in Jau, Sao Paulo, Brazil.	Water	59-64	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	86-89
15562942-1	2004	OBJECTIVES: This paper analyzes the impact of a 7-year interruption in water fluoridation on the prevalence of enamel fluorosis in Jau, state of Sao Paulo, Brazil.	Water	71-76	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	145-148
15461698-2	2004	Among many other examples, expression of aquaporin proteins in Xenopus oocytes and other heterologous expression systems has confirmed two important models of renal function: the increase in the water permeability of the collecting duct by antidiuretic hormone (ADH), and the mechanism of near isosmotic volume reabsorption by the proximal tubule.	Water	195-200	aquaporin	Xenopus laevis	41-50
15461698-7	2004	This model has also been confirmed in mice in which aquaporin-1 expression is knocked out, resulting in a low proximal tubule water permeability that exaggerates the development of luminal hypotonicity.	Water	126-131	aquaporin 1	Mus musculus	52-63
15366039-0	2004	Calculation of 19F and 27Al NMR parameters for rosenbergite, AlF[F0.5(H2O)0.5]4.H2O, a possible model for Al hydroxyfluorides in solution.	Water	70-73	afamin	Homo sapiens	61-64
15366039-0	2004	Calculation of 19F and 27Al NMR parameters for rosenbergite, AlF[F0.5(H2O)0.5]4.H2O, a possible model for Al hydroxyfluorides in solution.	Water	80-83	afamin	Homo sapiens	61-64
15366039-1	2004	(19)F and (27)Al NMR chemical shifts are calculated for the F and Al atoms of the mineral rosenbergite, AlF[F(0.5)(H(2)O)(0.5)](4).H(2)O The structure of rosenbergite consists of infinite chains of F-corner-sharing Al[F(4)(H(2)O)(2)] octahedra and isolated water molecules.	Water	257-262	afamin	Homo sapiens	104-107
15500134-2	2004	All classic physiological effects of AII, such as vasoconstriction, aldosterone and vasopressin release, sodium and water retention and sympathetic facilitation, are mediated by the AT1 receptor.	Water	116-121	angiotensin II receptor type 1	Homo sapiens	182-185
15378639-5	2004	Adsorbing ethanol and water from the vapour atmosphere results in a change of the surface properties of mica, either favouring adsorption or desorption of the graft polymer.	Water	22-27	MHC class I polypeptide-related sequence A	Homo sapiens	104-108
15173182-5	2004	The wide pore and the unexpectedly high proton permeability of TRPV1 point to a proton hopping permeation mechanism along the water-filled channel pore.	Water	126-131	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-68
15291512-5	2004	Here, we report a set of beta3-peptides that possess significant 14-helix structure in water; one recognizes a cleft on the surface of hDM2 with nanomolar affinity.	Water	87-92	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	135-139
15271714-3	2004	Changes in regional cerebral blood flow (rCBF) were identified by using SPM99 analysis of images obtained with positron emission tomography with (15)O water.	Water	151-156	CCAAT/enhancer binding protein zeta	Rattus norvegicus	41-45
15284286-9	2004	It is concluded that AE1 and SLC26A7 are differentially regulated in OMCD in water deprivation.	Water	77-82	solute carrier family 26 member 7	Rattus norvegicus	29-36
15234590-7	2004	TRH increased water intake in females, and CCK blocked this effect of TRH.	Water	14-19	thyrotropin releasing hormone	Rattus norvegicus	0-3
15299122-3	2004	Mannitol-induced water imbalance resulted in increased protein amounts in tonoplast fractions and a shift in protein distribution to other membrane fractions, suggesting aquaporin relocalization.	Water	17-22	aquaporin	Xenopus laevis	170-179
15145942-3	2004	Cox23p is homologous to Cox17p, a water-soluble copper protein previously implicated in the maturation of the Cu(A) center of cytochrome oxidase.	Water	34-39	copper metallochaperone COX17	Saccharomyces cerevisiae S288C	24-30
15026302-0	2004	Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments.	Water	81-86	transient receptor potential cation channel subfamily V member 4	Homo sapiens	58-63
15026302-11	2004	Therefore, TRPV4 is expressed in only those nephron segments that are constitutively (i.e., ATL, TAL, and DCT) or conditionally (i.e., collecting duct) water impermeant and where generation of a substantial transcellular osmotic gradient could be expected.	Water	152-157	transient receptor potential cation channel subfamily V member 4	Homo sapiens	11-16
15026302-12	2004	TRPV4 expression is absent from nephron segments exhibiting constitutive water permeability and unregulated apical aquaporin expression (i.e., PT and DTL).	Water	73-78	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
15180924-5	2004	Complementary RNA from two amino acid transporters yielded l-DOPA uptake significantly above water-injected controls the rBAT/b(0,+)AT dimer (rBAT) and the LAT2/4F2 dimer (LAT2).	Water	93-98	solute carrier family 7 member 8 S homeolog	Xenopus laevis	156-160
15236631-8	2004	Exposure to doxorubicin in an iso-osmotic medium (290 mOsmol/kg H2O) induced a rapid decrease in cell volume, as well as increases in annexin V labelling and caspase-3 activity, two biological markers of apoptosis.	Water	64-67	caspase-3	Oryctolagus cuniculus	158-167
15296798-10	2004	RESULTS: Seated SBP and DBP increased after water instillation with increases first noted between 5 and 8 min after the water had been instilled.	Water	44-49	selenium binding protein 1	Homo sapiens	16-19
15296798-11	2004	The BP remained elevated until 35 min post water increase over baseline being +36.5 mm Hg SBP and +24.3 mm Hg DBP.	Water	43-48	selenium binding protein 1	Homo sapiens	90-93
15189035-3	2004	One of the most potent and dopamine transporter (DAT) selective N-substituted benztropine analogues (N-(4-phenyl-n-butyl)-3alpha-(bis[4-fluorophenyl]methoxy)tropane, 1c) is devoid of cocaine-like behaviors in rodent models but is also highly lipophilic (cLogD = 5.01), which compromises its water solubility and may adversely affect its pharmacokinetic properties.	Water	291-296	solute carrier family 6 member 3	Rattus norvegicus	49-52
15189869-1	2004	The hydrophobic proteins SP-B and SP-C promote rapid adsorption of pulmonary surfactant to an air/water interface by an unknown mechanism.	Water	98-103	surfactant protein C	Bos taurus	34-38
15150578-6	2004	[(18)F]FETA, with an octanol-water partition coefficient of 0.16+/-0.01, was selectively retained by RIF-1 cells under hypoxia compared to air (3.4- to 4.3-fold at 60-120 min).	Water	29-34	ATPase, class I, type 8B, member 5	Mus musculus	7-11
15016717-5	2004	Compared with controls, leptin-treated animals gained significantly less weight and exhibited significantly reduced food and water intake.	Water	125-130	leptin	Rattus norvegicus	24-30
15221416-0	2004	Immunohistochemical localization of aquaporin 10 in the apical membranes of the human ileum: a potential pathway for luminal water and small solute absorption.	Water	125-130	aquaporin 10	Homo sapiens	36-48
15221416-7	2004	The presence of AQP10 in the apical membrane of intestinal villi suggests that this protein may represent an entry pathway for water and small solutes from the lumen across to the mucosal side.	Water	127-132	aquaporin 10	Homo sapiens	16-21
15181098-2	2004	Animal studies suggest a physiological role for GLP-1 in water and salt homeostasis.	Water	57-62	glucagon like peptide 1 receptor	Homo sapiens	48-53
15181098-3	2004	This study"s aim was to define the effects of GLP-1 on water and sodium excretion in both healthy and obese men.	Water	55-60	glucagon like peptide 1 receptor	Homo sapiens	46-51
15150284-9	2004	These data suggest that both AT1 and AT2 cells may contribute to the increased alveolar Na(+) and water clearance observed after exposure to beta2 adrenergic agents.	Water	98-103	angiotensin II receptor type 1	Homo sapiens	29-32
15150284-9	2004	These data suggest that both AT1 and AT2 cells may contribute to the increased alveolar Na(+) and water clearance observed after exposure to beta2 adrenergic agents.	Water	98-103	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	141-146
15969162-4	2004	The experiments have demonstrated the sensitivity of the surface shear viscosity (eta(s)) of protein and monoglyceride films at the air-water interface, as a function of surface pressure (or surface density).	Water	136-141	endothelin receptor type A	Homo sapiens	82-85
18950098-4	2004	Incorporation of K[(C2H4)PtCl3].H2O (a Zeise salt) into the PODS/ODC matrix, followed by reduction of the Pt ions by NaBH4 or H2, results in the localization of Pt compounds and nanoparticles along the siloxy bilayers, which remain dimensionally unchanged.	Water	32-35	ornithine decarboxylase 1	Homo sapiens	60-68
15267756-1	2004	The vibrational Stokes shift of the OH stretching transition nu(OH) of water is the shift between the ground-state absorption and the excited-state (v=1) emission.	Water	71-76	immunoglobulin kappa variable 1-5	Homo sapiens	149-152
15118100-1	2004	Mate attraction in Aplysia involves a long-distance water-borne signal (the protein pheromone attractin), which is released during egg laying.	Water	52-57	attractin	Aplysia californica	94-103
15056008-0	2004	Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility.	Water	137-142	epoxide hydrolase 2	Homo sapiens	98-123
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Water	226-231	nei like DNA glycosylase 2	Homo sapiens	85-91
15041674-3	2004	Here we have studied the association behavior of the bacterial light-harvesting protein LH2 from Rhodobacter spheroides in an n,n-dimethyldodecylamine-n-oxide/water environment.	Water	159-164	LIM homeobox 2	Homo sapiens	88-91
15044611-0	2004	An active and water-soluble truncation mutant of the human UDP-glucuronosyltransferase 1A9.	Water	14-19	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	59-90
15044611-1	2004	The UDP-glucuronosyltransferases (UGTs) are integral membrane proteins, and previous attempts to generate a water-soluble UGT by removing the single trans-membrane helix yielded inactive and membrane-bound proteins.	Water	108-113	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	34-37
15132310-2	2004	In the present investigation a recently constructed non-invasive device for a local measurement of changes in tissue water in human skin and subcutaneous fat (SSF) was validated.	Water	117-122	peter pan homolog	Homo sapiens	159-162
15132310-6	2004	From the information of the reflected wave an electrical parameter, directly proportional to tissue water content, called a dielectric constant of SSF, was calculated.	Water	100-105	peter pan homolog	Homo sapiens	147-150
15132310-7	2004	For system validation, the decrease of water content in SSF measured with the dielectric technique in the volar forearm of seven patients during haemodialysis treatment was compared with the decrease of the circumference of the forearm and the amount of fluid removed.	Water	39-44	peter pan homolog	Homo sapiens	56-59
15132310-8	2004	Statistically highly significant correlations were obtained between the decreasing dielectric constant (i.e. water content) of the SSF and the fluid removed during haemodialysis treatment (r = -0.99, p &lt; 0.01) and between the decreasing dielectric constant and the circumference of the arm (r = 0.97, p &lt; 0.05).	Water	109-114	peter pan homolog	Homo sapiens	131-134
2558010-2	1989	A water soluble carbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), has been used to crosslink horse heart cytochrome c and trypsin-solubilized bovine liver microsomal cytochrome b5.	Water	2-7	cytochrome c, somatic	Equus caballus	122-134
15132310-11	2004	The new device allows an easy and non-invasive measurement technique to assess changes of tissue water in SSF.	Water	97-102	peter pan homolog	Homo sapiens	106-109
15109940-3	2004	Both the AT1 and AT2 ligands administered into the LSA elicited a concentration-dependent decrease in the water intake induced by AVP injected into the LSA, but losartan was more effective than CGP42112A.	Water	106-111	angiotensin II receptor, type 1a	Rattus norvegicus	9-12
2642194-2	1989	When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure.	Water	49-54	neurolysin	Homo sapiens	34-37
15109940-3	2004	Both the AT1 and AT2 ligands administered into the LSA elicited a concentration-dependent decrease in the water intake induced by AVP injected into the LSA, but losartan was more effective than CGP42112A.	Water	106-111	angiotensin II receptor, type 2	Rattus norvegicus	17-20
15018733-1	2004	Pancreatic cancer has low levels of antioxidant enzymes including manganese superoxide dismutase (MnSOD), which converts superoxide radical (O(2)(*-)) into hydrogen peroxide (H(2)O(2)), and glutathione peroxidase (GPx), which converts H(2)O(2) into water.	Water	249-254	superoxide dismutase 2	Homo sapiens	66-96
2642194-2	1989	When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure.	Water	49-54	neurolysin	Homo sapiens	80-83
2642194-2	1989	When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure.	Water	49-54	neurolysin	Homo sapiens	80-83
2642194-2	1989	When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure.	Water	124-129	neurolysin	Homo sapiens	34-37
2642194-2	1989	When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure.	Water	124-129	neurolysin	Homo sapiens	80-83
15018733-1	2004	Pancreatic cancer has low levels of antioxidant enzymes including manganese superoxide dismutase (MnSOD), which converts superoxide radical (O(2)(*-)) into hydrogen peroxide (H(2)O(2)), and glutathione peroxidase (GPx), which converts H(2)O(2) into water.	Water	249-254	superoxide dismutase 2	Homo sapiens	98-103
14742199-4	2004	Transformation of Escherichia coli BL21(DE3) by the recombinant plasmid pCIP51 resulted in the export of the mature YbxI in the periplasm as a water-soluble protein.	Water	143-148	exported beta-lactamase	Bacillus subtilis subsp. subtilis str. 168	116-120
18588191-5	1989	The main result for the dipeptides was that knowledge of the partition coefficient in any of the PEG/dextran/water systems, regardless of polymer molecular weight, enabled prediction of the coefficient in all of the systems.	Water	109-114	progestagen associated endometrial protein	Homo sapiens	97-100
18588191-7	1989	This quantity was correlated with polymer concentration, thus establishing a hydrophobicity profile for the PEG/ dextran/water systems.	Water	121-126	progestagen associated endometrial protein	Homo sapiens	108-111
14704269-1	2004	The binding site of the dopamine D(2) receptor (D2R), like those of homologous rhodopsin-like G protein-coupled receptors (GPCRs) that bind small molecules, is contained within a water-accessible crevice formed among its seven transmembrane segments (TMs).	Water	179-184	dopamine receptor D2	Bos taurus	24-46
2691501-2	1989	Human NCF was present in both the soluble and insoluble protein fractions of the homogenate of host cells, and it was partially purified as a water-soluble polypeptide from both fractions, separately.	Water	142-147	neutrophil cytosolic factor 4	Homo sapiens	6-9
14695288-2	2004	The water-soluble LF-MBP, extracted at pH &lt; 3.0 from defatted brain, is the classical preparation of MBP, commonly regarded as an intrinsically unfolded protein.	Water	4-9	myelin basic protein	Homo sapiens	21-24
2485681-1	1989	Preimmunization of rnu/+ rats with the mouse monoclonal antibody S2D2 against retinal S-antigen (S-Ag) leads to an anti-idiotypic (anti-Id) response and to protection against experimental autoimmune uveoretinitis (EAU) provoked by a subsequent challenge with S-Ag in complete Freund"s adjuvant (CFA).	Water	214-217	S-antigen visual arrestin	Rattus norvegicus	78-95
2485681-1	1989	Preimmunization of rnu/+ rats with the mouse monoclonal antibody S2D2 against retinal S-antigen (S-Ag) leads to an anti-idiotypic (anti-Id) response and to protection against experimental autoimmune uveoretinitis (EAU) provoked by a subsequent challenge with S-Ag in complete Freund"s adjuvant (CFA).	Water	214-217	S-antigen visual arrestin	Rattus norvegicus	97-101
14695288-2	2004	The water-soluble LF-MBP, extracted at pH &lt; 3.0 from defatted brain, is the classical preparation of MBP, commonly regarded as an intrinsically unfolded protein.	Water	4-9	myelin basic protein	Homo sapiens	104-107
14695301-7	2004	These results demonstrate that the H2O-to-D2O-induced increase in beta-endorphin release corresponded with the redistribution of actin, and the D2O-to-H2O-induced decrease in beta-endorphin release corresponded with the inhibition of voltage-sensitive Ca2+ channels.	Water	35-38	pro-opiomelanocortin-alpha	Mus musculus	66-80
2789441-3	1989	The binding of HD11 to T-2 conjugated to bovine serum albumin was inhibited by free T-2 toxin but not by the water-soluble heterocyclic guanidines saxitoxin and tetrodotoxin.	Water	109-114	histone deacetylase 11	Homo sapiens	15-19
14695301-7	2004	These results demonstrate that the H2O-to-D2O-induced increase in beta-endorphin release corresponded with the redistribution of actin, and the D2O-to-H2O-induced decrease in beta-endorphin release corresponded with the inhibition of voltage-sensitive Ca2+ channels.	Water	35-38	pro-opiomelanocortin-alpha	Mus musculus	175-189
14695301-7	2004	These results demonstrate that the H2O-to-D2O-induced increase in beta-endorphin release corresponded with the redistribution of actin, and the D2O-to-H2O-induced decrease in beta-endorphin release corresponded with the inhibition of voltage-sensitive Ca2+ channels.	Water	151-154	pro-opiomelanocortin-alpha	Mus musculus	175-189
2503030-4	1989	Comparison of the molecular packing of apolipoproteins A-I and A-II suggests that apoA-II adopts a more condensed conformation at the lipid/water interface compared to apoA-I.	Water	140-145	apolipoprotein A2	Homo sapiens	82-89
14724097-5	2004	RESULTS: MAO mAb administration significantly reduced the brain water content in the gray and white matter as well as the permeability of BBB (P&lt;0.01), Which was especially effective for the white matter, producing results comparable with those of the non-edema group (P&gt;0.05).	Water	64-69	monoamine oxidase A	Rattus norvegicus	9-12
2533478-4	1989	In 6 healthy dogs, while histamine 4.0 micrograms/min free base on average was being infused into a femoral vein, the infusion of ANP increased sodium excretion by 168 microEq/min, compared to 160 microEq/min when the same dose of histamine was being infused into the portal vein (portal pressure increased by 46% or 6 cm H2O).	Water	322-325	natriuretic peptide A	Canis lupus familiaris	130-133
14724097-6	2004	MAO mAb markedly alleviated brain edema, with better dehydrating effect on the white matter than mannitol (P&lt;0.01), which reduced the water content of the brain gray and white matter undiscriminatingly and showed poor effect on the permeability of BBB.	Water	137-142	monoamine oxidase A	Rattus norvegicus	0-3
15546411-7	2004	A secondary inhibition of growth in E. nidulans cultures by the oxygen-depleting GOX-catalase system was likely to replace the primary inhibition exerted by H(2)O(2).	Water	157-162	catalase	Bos taurus	85-93
2777081-1	1989	zeta-Crystallin is a major component of the water-soluble proteins of the guinea pig lens.	Water	44-49	quinone oxidoreductase	Cavia porcellus	0-15
2692710-10	1989	Two of the five active-site glycines in wild-type p21.GDP have very slow amide proton exchange rates with water (kappa less than 2.8 x 10(-5) s-1).	Water	106-111	H3 histone pseudogene 16	Homo sapiens	50-53
2483169-1	1989	Gramicidin S (GrS) suppressed the onset of experimental autoimmune uveoretinitis (EAU) induced with S-antigen in rats, and the proliferation of mitogen-stimulated lymphocytes in culture.	Water	82-85	S-antigen visual arrestin	Rattus norvegicus	100-109
15479561-6	2004	To overcome this, a synthetic water-dispersible derivative of astaxanthin has been synthesized and shown to be: highly bioavailable; a potent antioxidant; protective against experimental ischemia-reperfusion injury and capable of inducing Cx43, suggesting antineoplastic potential.	Water	30-35	gap junction protein alpha 1	Homo sapiens	239-243
2723676-6	1989	The increased brain water content as well as the elevated plasma and brain histamine levels were prevented by prior treatment with the histamine H2-receptor antagonist cimetidine.	Water	20-25	histamine receptor H 2	Rattus norvegicus	135-156
14728794-4	2003	Water requirements to produce adequate diets for humans are shown to be relatively generic irrespective of hydro-climate, amounting to a global average of 1,300 m(3) cap(-1) yr(-1).	Water	0-5	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	166-172
2492530-2	1989	A new water-soluble color reagent, 4-N,N-dimethylaminoazobenzene-4"-isothiocyano-2"-sulfonic acid (S-DABITC), was used to identify lysine residues of antithrombin III which participate in the binding of heparin.	Water	6-11	serpin family C member 1	Homo sapiens	150-166
2551391-6	1989	A simple isolation protocol was developed in which inclusion body material was first solubilized in 3 M guanidine hydrochloride, and the mIL-1 alpha was then simultaneously purified and allowed to fold to its active conformation by dialysis against distilled water.	Water	259-264	interleukin 1 alpha	Mus musculus	137-148
2526745-3	1989	Water deprivation for 24 h induced an antidiuresis while the plasma osmolality, plasma AVP and plasma ANP remained at physiological levels.	Water	0-5	arginine vasopressin	Canis lupus familiaris	87-90
14673090-1	2003	Mitochondrial cytochrome c oxidase plays an essential role in aerobic cellular respiration, reducing dioxygen to water in a process coupled with the pumping of protons across the mitochondrial inner membrane.	Water	113-118	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	14-34
2526745-3	1989	Water deprivation for 24 h induced an antidiuresis while the plasma osmolality, plasma AVP and plasma ANP remained at physiological levels.	Water	0-5	natriuretic peptide A	Canis lupus familiaris	102-105
2526745-6	1989	Oral water loading (20 ml/kg body weight) induced low plasma AVP levels (1.3 +/- 0.5 pg/ml, mean +/- S.E.M.).	Water	5-10	arginine vasopressin	Canis lupus familiaris	61-64
2526745-7	1989	Following AVP administration to the water-loaded group, the urine production rate decreased significantly from baseline while the osmolality of the urine increased significantly.	Water	36-41	arginine vasopressin	Canis lupus familiaris	10-13
2540498-1	1989	The primary photochemical reactions of cattle rhodopsin suspended in H2O or D2O were compared between excitation with both a weak and an intense picosecond laser pulse (wavelength, 532 nm; duration, 25 ps) at room temperature.	Water	69-72	rhodopsin	Bos taurus	46-55
2496574-5	1989	Additionally, the multiple forms of water-soluble AChE were separated by microelectrophoresis.	Water	36-41	acetylcholinesterase	Rattus norvegicus	50-54
14662748-1	2003	Vasopressin regulates body water conservation by redistributing aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical surface of renal collecting ducts, resulting in water reabsorption from urine.	Water	27-32	arginine vasopressin S homeolog	Xenopus laevis	0-11
2505090-2	1989	The present study reveals that pretreatment of C57Bl/6JHan mice of both sexes with one s.c. dose of 120 mg of In2(SO4)3.5 H2O per kg of body weight decreases the concentration of cytochrome P-450 to about 65% of control levels.	Water	122-125	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	179-195
14662748-1	2003	Vasopressin regulates body water conservation by redistributing aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical surface of renal collecting ducts, resulting in water reabsorption from urine.	Water	83-88	arginine vasopressin S homeolog	Xenopus laevis	0-11
14662748-1	2003	Vasopressin regulates body water conservation by redistributing aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical surface of renal collecting ducts, resulting in water reabsorption from urine.	Water	83-88	arginine vasopressin S homeolog	Xenopus laevis	0-11
2720108-1	1989	Leucine-enkephalin (Try1-Gly2-Gly3-Phe4-Leu5) has been crystallized as a trihydrate from water solution.	Water	89-94	tripartite motif containing 13	Homo sapiens	40-44
14644413-9	2003	The solvent perturbation of kinetic parameters was pH-dependent, and the pK(1) from the acidic side and the pK(2) from the basic side were shifted down 0.4 pH units and shifted up 0.6 units as water was replaced by 15% ethanol, respectively.	Water	193-198	probable protein kinase At2g41970	Nicotiana tabacum	73-78
2659859-9	1989	In addition, BN rats resistant to EAU exhibited very high levels of antibody to S-antigen.	Water	34-37	S-antigen visual arrestin	Rattus norvegicus	80-89
2726747-4	1989	AMH dramatically decreases the conversion rate of testosterone to estradiol and also decreases total aromatase activity, as measured by the tritiated water technique.	Water	150-155	anti-Mullerian hormone	Rattus norvegicus	0-3
2752065-4	1989	The cytochrome P-450scc-cytochrome b5 complex may be cross-linked with water-soluble carbodiimide.	Water	71-76	cytochrome b5 type A	Homo sapiens	24-37
2507980-10	1989	Extensive rinsing of the module with water before extract preparation totally mitigated the in-vitro production of interleukin-1.	Water	37-42	interleukin 1 alpha	Homo sapiens	115-128
14644413-9	2003	The solvent perturbation of kinetic parameters was pH-dependent, and the pK(1) from the acidic side and the pK(2) from the basic side were shifted down 0.4 pH units and shifted up 0.6 units as water was replaced by 15% ethanol, respectively.	Water	193-198	probable protein kinase At2g41970	Nicotiana tabacum	108-113
12802622-2	2003	LU105 was extracted from seeds of L. albus and is freely soluble in water.	Water	68-73	secretoglobin family 3A member 1	Homo sapiens	0-5
3233147-1	1988	A method for measuring the content of two groups of microsomal cytochrome P-450 isozymes--cytochromes P-450W and P-450L--with the active sites directed into the water phase and membrane lipids, respectively, has been developed.	Water	161-166	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	63-79
14638900-3	2003	Activation of NHE3 may be a pathophysiologically important factor in the development of renal salt and water retention observed in the nephrotic syndrome.	Water	103-108	solute carrier family 9 member A3	Rattus norvegicus	14-18
3263170-4	1988	Since the supraoptic and paraventricular nuclei secrete the antidiuretic hormone, their excitation may offer a partial explanation of the considerable water retention observed during IL-2 therapy against neoplasia.	Water	151-156	interleukin 2	Rattus norvegicus	183-187
2563651-3	1989	There was a positive correlation between the octanol/water partition coefficients of these agents and their inhibition of lipoprotein lipase, suggesting that hydrophobicity may be one of the major determinants for PHLpL inhibition.	Water	53-58	lipoprotein lipase	Homo sapiens	122-140
15007468-5	2003	The results showed that the gold labeled antibodies functioned comparably with a fluorescent based immunoassay for detecting BAM in water.	Water	132-137	structural maintenance of chromosomes 3	Homo sapiens	125-128
2733028-5	1989	These modified polymers were then covalently linked either to monoclonal antimyosin antibody or to its Fab fragment by means of a water soluble carbodiimide.	Water	130-135	FA complementation group B	Homo sapiens	103-106
2847775-1	1988	Upon incubation of detergent-solubilized NADPH-cytochrome P-450 reductase and either cytochrome b5 or cytochrome c in the presence of a water-soluble carbodiimide, a 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC), covalently cross-linked complex was formed.	Water	136-141	cytochrome b5 type A	Homo sapiens	85-98
2710998-7	1989	We conclude that SAG plays a role in food and water intake in the mouse and both behaviors are interdependent processes.	Water	46-51	S-antigen, retina and pineal gland (arrestin)	Mus musculus	17-20
15007468-6	2003	A qualitative immunoassay based on gold-labeled antibodies could determine if a water sample contained BAM above and below 60-70 ng L(-1), which is below the maximum allowed BAM concentration for drinking water (100 ng L(-1)) according to European Union legislation.	Water	80-85	structural maintenance of chromosomes 3	Homo sapiens	103-106
14561082-1	2003	A novel water-soluble paclitaxel complex has been prepared by inclusion complexation with bridged bis(beta-cyclodextrin)s and characterized by means of (1)H NMR, SEM, powder X-ray diffraction patterns, TG-DTA, DSC, FT-IR, and 2D NOESY.	Water	8-13	desmocollin 3	Homo sapiens	210-213
15092450-0	1989	A new micro-detection tube for cholinesterase inhibitors in water.	Water	60-65	butyrylcholinesterase	Homo sapiens	31-45
15092450-1	1989	A cheap and simple but very sensitive and specific detection tube has been developed for the detection of cholinesterase-inhibiting compounds in natural and waste water disinfected with chlorine-containing oxidants.	Water	163-168	butyrylcholinesterase	Homo sapiens	106-120
14563709-6	2003	GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and on epithelial cell growth and differentiation.	Water	84-89	guanylate cyclase 2C	Homo sapiens	0-4
2566666-4	1989	Investigation of DP IV-inactivation, DP IV-catalyzed hydrolysis of N-Ala-Pro-O-Bz(4-NO2) and the decomposition of the suicide substrate in H2O and D2O gave solvent isotope effects of 4.65, 2.54 and 1.02, respectively.	Water	139-142	dipeptidyl peptidase 4	Homo sapiens	37-42
14561474-1	2003	Two small hydrophobic proteins, SP-B and SP-C, are responsible for rapid adsorption of pulmonary surfactant to the air/water interface.	Water	119-124	surfactant protein C	Bos taurus	41-45
12972251-6	2003	The interactions made by human TFIIA with TBP and DNA within and upstream of the TATA box, including those involving water molecules, are described and compared to the yeast structure.	Water	117-122	general transcription factor IIA subunit 1	Homo sapiens	31-36
2965177-2	1988	In four female calves fitted with a Foley catheter, an intravenous administration of ANF (Ile-ANF 26; 1.6 micrograms/kg body wt during 30 min) induced an increase (P less than 0.01) in urine flow rate (from 1.8 +/- 0.2 to 12.8 +/- 1.1 ml/min), sodium excretion (from 0.15 +/- 0.02 to 0.81 +/- 0.06 mmol/min) and free water clearance (from 0.13 +/- 0.9 to 5.16 +/- 0.5 ml/min).	Water	317-322	natriuretic peptide A	Bos taurus	85-88
2965177-2	1988	In four female calves fitted with a Foley catheter, an intravenous administration of ANF (Ile-ANF 26; 1.6 micrograms/kg body wt during 30 min) induced an increase (P less than 0.01) in urine flow rate (from 1.8 +/- 0.2 to 12.8 +/- 1.1 ml/min), sodium excretion (from 0.15 +/- 0.02 to 0.81 +/- 0.06 mmol/min) and free water clearance (from 0.13 +/- 0.9 to 5.16 +/- 0.5 ml/min).	Water	317-322	natriuretic peptide A	Bos taurus	90-100
12946157-0	2003	Green protocol for conjugate addition of thiols to alpha,beta-unsaturated ketones using a [bmim]PF6/H2O system.	Water	100-103	sperm associated antigen 17	Homo sapiens	96-99
2450765-1	1988	The contractile response to substance P (SP), neurokinin A (NKA) and arginin-neurokinin B (Arg-NKB) (a water soluble analogue of NKB) was investigated in detrusor muscle strips from the dome of the urinary bladder obtained from patients undergoing total cystectomy for carcinoma of the bladder base.	Water	103-108	tachykinin precursor 3	Homo sapiens	95-98
14632084-2	2003	In addition, HO2 is found in droplets and surface water as a result of photochemical formation and gas-phase scavenging.	Water	50-55	heme oxygenase 2	Homo sapiens	13-16
3066120-6	1988	Both plasma renin activity (PRA) and aldosterone (PA) concentration increased after water, but decreased after saline administration.	Water	84-89	renin	Capra hircus	12-17
3075842-5	1988	Insulin or IGF-I caused a large initial weight gain in diabetic rats, accompanied by a partial correction of food and water balance, even in the presence of persistent hyperglycaemia.	Water	118-123	insulin-like growth factor 1	Rattus norvegicus	11-16
12911542-1	2003	BACKGROUND: Mutations in the renal K+ channel ROMK (Kir 1.1) cause hyperprostaglandin E syndrome/antenatal Bartter syndrome (HPS/aBS), a severe tubular disorder leading to renal salt and water wasting.	Water	187-192	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	46-50
2902975-0	1988	ADH-induced water permeability: what role for the microtubular network?	Water	12-17	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	0-3
2902975-2	1988	ADH-induced intramembrane particle aggregates in the apical membrane of the epithelial cells are specifically related to water permeability in the epithelium.	Water	121-126	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	0-3
2902975-4	1988	Colchicine and nocadozole (both of which bind to tubulin) inhibit ADH-induced osmotic water flow in the amphibian bladder.	Water	86-91	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	66-69
12911542-1	2003	BACKGROUND: Mutations in the renal K+ channel ROMK (Kir 1.1) cause hyperprostaglandin E syndrome/antenatal Bartter syndrome (HPS/aBS), a severe tubular disorder leading to renal salt and water wasting.	Water	187-192	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	52-59
12899634-1	2003	Tissue transglutaminase (TGase) catalyzes transfer of gamma-acyl moieties of Gln residues in peptides or protein substrates to either water or amine nucleophiles through an acyl-enzyme intermediate formed from initial acyl-transfer to an active site Cys residue.	Water	134-139	transglutaminase 1	Homo sapiens	25-30
14572062-11	2003	Our optrode design allows for the fast removal of nonbound ions from the PCCA by washing with pure water.	Water	99-104	propionyl-CoA carboxylase subunit alpha	Homo sapiens	73-77
3147420-6	1988	During treatment, an increase of the calculated beta 2-microglobulin distribution volume occurred with all three membranes, probably representing extra-to-intracellular water shifts.	Water	169-174	beta-2-microglobulin	Homo sapiens	48-68
3147420-7	1988	The water shifts occurring during haemofiltration reduce the value of precision of beta 2-microglobulin kinetics and limit the value of the plasma level decrease as an index of beta 2-microglobulin removal.	Water	4-9	beta-2-microglobulin	Homo sapiens	83-103
3147420-7	1988	The water shifts occurring during haemofiltration reduce the value of precision of beta 2-microglobulin kinetics and limit the value of the plasma level decrease as an index of beta 2-microglobulin removal.	Water	4-9	beta-2-microglobulin	Homo sapiens	177-197
12882779-3	2003	The fractional content of serum albumin was determined in water-soluble extracts of cornea by imaging analyses after SDS-PAGE.	Water	58-63	albumin	Mus musculus	32-39
3249755-0	1988	Characterization of central actions of neuropeptide Y on food and water intake in rabbits.	Water	66-71	neuropeptide Y	Oryctolagus cuniculus	39-53
3249755-8	1988	These observations are consistent with specific stimulatory effects of NPY on food and water intake.	Water	87-92	neuropeptide Y	Oryctolagus cuniculus	71-74
12882779-5	2003	RESULTS: SDS-PAGE (-DTT) resolved mouse serum albumin and transketolase and indicated that serum albumin was 13% of the water-soluble protein in whole mouse corneas.	Water	120-125	albumin	Mus musculus	97-104
12887424-7	2003	In the Morris water maze the p25 mutants were normal in learning an initial platform location, but surprisingly reversal learning was improved when the platform position was changed.	Water	14-19	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	29-32
3217593-7	1988	Pdi values obtained by SMC (36.5 +/- 13.5 cm H2O) and their relation to maximal Pdi (22.6 +/- 7%) and to the Pdi at the time of maximal sniff-Pdi sniff (34.7 +/- 8%) were comparable to those values obtained using other methods and were reproducible.	Water	45-48	peptidyl arginine deiminase 1	Homo sapiens	0-3
12779324-3	2003	The patatin crystal structure has three molecules in the asymmetric unit, an R-factor of 22.0%, and an R(free) of 27.2% (for 10% of the data not included in the refinement) and includes 498 water molecules.	Water	190-195	Patatin-2-Kuras 1	Solanum tuberosum	4-11
3442661-5	1987	Application of this method to ATP in equilibrium with HOH exchange during single turnovers of myosin indicates that the bulk of the ATP undergoes rapid washout of gamma-nonbridge oxygens in the virtual absence of PIX.	Water	54-57	myosin heavy chain 14	Homo sapiens	94-100
12820976-7	2003	This structure indicates a more invasive interaction with dsDNA than observed with other UDGs and reveals an elegant water displacement/replacement mechanism that allows SMUG1 to exclude thymine from its active site while accepting HmU.	Water	117-122	single-strand-selective monofunctional uracil-DNA glycosylase 1	Homo sapiens	170-175
3326562-2	1987	The objective of the present article is to clarify the beta 2-microglobulin removal characteristics of dialysis membranes having varying water contents and pore radii.	Water	137-142	beta-2-microglobulin	Homo sapiens	55-75
12711183-4	2003	DSC and TGA showed that lactose crystals produced from Carbopol gel or from water-ethanol solution existed as alpha-lactose monohydrate.	Water	76-81	desmocollin 3	Homo sapiens	0-3
3691449-4	1987	Both main-stream and side-stream cigarette smoke condensates and some fractions, containing water-soluble bases, water-insoluble bases, and polycyclic aromatic hydrocarbons, were found to induce AHH activity in lung and liver, the lung being induced to the greatest extent.	Water	92-97	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	195-198
3691449-4	1987	Both main-stream and side-stream cigarette smoke condensates and some fractions, containing water-soluble bases, water-insoluble bases, and polycyclic aromatic hydrocarbons, were found to induce AHH activity in lung and liver, the lung being induced to the greatest extent.	Water	113-118	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	195-198
12711183-4	2003	DSC and TGA showed that lactose crystals produced from Carbopol gel or from water-ethanol solution existed as alpha-lactose monohydrate.	Water	76-81	T-box transcription factor 1	Homo sapiens	8-11
12727049-0	2003	Rapid proton fat-water spectroscopy for the characterization of non-CNS lesions in vivo.	Water	17-22	FAT atypical cadherin 1	Homo sapiens	13-16
3427588-1	1987	1,3-Dimethyl-8-beta-D-ribofuranosylxanthine monohydrate, C12H16N4O6.H2O, is monoclinic, P21, with two molecules in a unit cell having a = 8.186(1), b = 19.222(3), c = 4.7655(8) A, beta = 103.79(1) degrees, V = 728.2 A, and Dx = 1.506 g.cm-3.	Water	68-71	H3 histone pseudogene 16	Homo sapiens	88-91
12727049-3	2003	The goal of this study was to develop a rapid clinically practical proton spectroscopy procedure for the direct observation of a localized fat-water signal within the body.	Water	143-148	FAT atypical cadherin 1	Homo sapiens	139-142
12727049-4	2003	The technique developed reliably determined fat-water ratios in phantoms and from lesions in vivo in 6 s with single voxel sizes as small as 0.125 cc.	Water	48-53	FAT atypical cadherin 1	Homo sapiens	44-47
2957260-13	1987	In contrast, cotyledon water potential exhibits a decrease that correlates with the late induction of Lea mRNAs.	Water	23-28	late embryogenesis abundant protein D-34	Gossypium hirsutum	102-105
12700414-3	2003	In this study we show by electrophoretic mobility-shift assay (EMSA) that enriched splenic NK cells from EtOH-consuming C57BL/6 mice exhibit reduced NF-kappaB and AP-1 binding activity in response to IL-2 stimulation as compared to the water-drinking mice.	Water	236-241	jun proto-oncogene	Mus musculus	163-167
12837184-6	2003	RESULTS: TRH or HSD used alone or in combination significantly increased MAP, LVSP and +/- dp/dt max (P&lt;0.05 or P&lt;0.01 ), ameliorated acid-base imbalance, and decreased the water content of lung and brain.	Water	179-184	thyrotropin releasing hormone	Rattus norvegicus	9-12
3111852-4	1987	When the enzyme was solubilised from a melanosomal fraction with detergent/water without any buffer, significant linear activity for 2 h was seen at an inhibitory concentration of tyrosine, indicating for the first time the presence of a form of tyrosinase without lag and inhibition by excess tyrosine.	Water	75-80	tyrosinase	Mus musculus	246-256
3136663-4	1988	Pretreatment with difluoromethylornithine (DFMO), an irreversible inhibitor of ODC, as a 1% drinking water solution inhibited both base-line renal ODC activity and putrescine concentration as well as increases stimulated by UN, although concentrations of spermidine and spermine were not decreased.	Water	101-106	ornithine decarboxylase 1	Rattus norvegicus	79-82
3136663-4	1988	Pretreatment with difluoromethylornithine (DFMO), an irreversible inhibitor of ODC, as a 1% drinking water solution inhibited both base-line renal ODC activity and putrescine concentration as well as increases stimulated by UN, although concentrations of spermidine and spermine were not decreased.	Water	101-106	ornithine decarboxylase 1	Rattus norvegicus	147-150
12686139-3	2003	Here we construct unambiguous connection diagrams that describe the interactions among the three non-ester phosphate oxygen atoms of PLP and surrounding atoms from the protein binding site and from water molecules, the so-called phosphate group binding "cup".	Water	198-203	pyridoxal phosphatase	Homo sapiens	133-136
3415847-2	1988	Tween 80 is a water-soluble substrate, and thus estimates esterase activity.	Water	14-19	AT695_RS05650	Staphylococcus aureus	58-66
3038863-11	1987	The deuterium studies suggest that neutrophil collagenase, acting on type III fibrils (kappa H2O/kappa D2O = 5.0), is less sensitive to factors which govern the availability of water at the relatively hydrophobic site of peptide bond hydrolysis in the collagen molecule than is fibroblast collagenase (kappa H2O/kappa D2O = 15.0).	Water	93-96	matrix metallopeptidase 8	Homo sapiens	35-57
12662064-7	2003	This study highlights the role of both water molecules and bulk solvent effect in influencing the tautomeric equilibria of the PLP related compounds.	Water	39-44	pyridoxal phosphatase	Homo sapiens	127-130
3038863-11	1987	The deuterium studies suggest that neutrophil collagenase, acting on type III fibrils (kappa H2O/kappa D2O = 5.0), is less sensitive to factors which govern the availability of water at the relatively hydrophobic site of peptide bond hydrolysis in the collagen molecule than is fibroblast collagenase (kappa H2O/kappa D2O = 15.0).	Water	177-182	matrix metallopeptidase 8	Homo sapiens	35-57
3038863-11	1987	The deuterium studies suggest that neutrophil collagenase, acting on type III fibrils (kappa H2O/kappa D2O = 5.0), is less sensitive to factors which govern the availability of water at the relatively hydrophobic site of peptide bond hydrolysis in the collagen molecule than is fibroblast collagenase (kappa H2O/kappa D2O = 15.0).	Water	308-311	matrix metallopeptidase 8	Homo sapiens	35-57
3191510-8	1988	It appears that, for AH8-34, the trisaccharide is accepted with OH-2 of the beta-D-Galp group and OH-3 of the alpha-L-Fucp group intramolecularly hydrogen-bonded to neighboring proton acceptors.	Water	64-68	galanin like peptide	Homo sapiens	83-87
2456024-1	1988	The effects of standard, fat-rich, protein-rich, and carbohydrate-rich diets combined with either long-term ethanol ingestion or tap water ingestion on the behavior of plasma phospholipase A2 activity during experimental acute pancreatitis were studied in rats.	Water	133-138	phospholipase A2 group IB	Rattus norvegicus	175-191
3299912-4	1987	The water-soluble RT1-A molecule had a discrete heavy chain of 40 kD, linked noncovalently to beta 2 microglobulin.	Water	4-9	beta-2 microglobulin	Rattus norvegicus	94-114
12391040-4	2003	A surprising pattern was seen in hysteresivity (eta), with a plateau at low lung volumes (Pao &lt; 10 cm H2O), a sharp fall occurring between 10 and 15 cm H2O, and eta approaching a second (lower) plateau at higher lung volumes.	Water	105-108	endothelin receptor type A	Mus musculus	48-51
3418713-3	1988	Using N-methylacetamide as a model peptide, the free energies of the following processes were determined; (1) formation of the C=O ... H-N bond in water, (2) formation of the C=O ... N-N bond in CCl4, and (3) transfer of N-methylacetamide from water to CCl4.	Water	147-152	C-C motif chemokine ligand 4	Homo sapiens	195-199
3418713-3	1988	Using N-methylacetamide as a model peptide, the free energies of the following processes were determined; (1) formation of the C=O ... H-N bond in water, (2) formation of the C=O ... N-N bond in CCl4, and (3) transfer of N-methylacetamide from water to CCl4.	Water	147-152	C-C motif chemokine ligand 4	Homo sapiens	253-257
3418713-4	1988	(4) From (3), the free energy of transferring the non-hydrogen bonded (C=O, H-N) group from water to CCl4 was calculated.	Water	92-97	C-C motif chemokine ligand 4	Homo sapiens	101-105
3418713-5	1988	When the free energies of (1), (2) and (4) are combined, one finds that the free energy of transferring the C=O ... H-N group from water to CCl4 is a surprising -1.4 kcal/mol (1 cal = 4.184 J).	Water	131-136	C-C motif chemokine ligand 4	Homo sapiens	140-144
3567925-10	1987	This concentration of ANF was observed to inhibit the metabolism of [3H]B(a)P by splenocyte cultures to water soluble metabolites.	Water	104-109	natriuretic peptide type A	Mus musculus	22-25
3418713-7	1988	In the present report, it is shown that this apparent hydrophobicity results from an underestimation of the free energy contribution that the methyl groups make to the transfer of N-methylacetamide from water to CCl4.	Water	203-208	C-C motif chemokine ligand 4	Homo sapiens	212-216
12391040-4	2003	A surprising pattern was seen in hysteresivity (eta), with a plateau at low lung volumes (Pao &lt; 10 cm H2O), a sharp fall occurring between 10 and 15 cm H2O, and eta approaching a second (lower) plateau at higher lung volumes.	Water	155-158	endothelin receptor type A	Mus musculus	48-51
3418713-8	1988	When appropriate methyl group transfer free energies are used, one finds that the free energy of transferring the C=O ... H-N group from water to CCl4 is +0.62 kcal/mol.	Water	137-142	C-C motif chemokine ligand 4	Homo sapiens	146-150
12639118-2	2003	Addition of aqueous H(2)O(2) to methanol solutions of the Mn(II) complexes of L(1) and L(2) produced green solutions in a fast reaction from which subsequently precipitated brown solids of the dioxo-bridged dinuclear complexes 1 and 2, respectively, which have the general formula [LMn(III)(mu-O)(2)Mn(III)L](ClO(4))(2).	Water	20-25	immunoglobulin kappa variable 3-15	Homo sapiens	87-91
2952021-8	1987	It is concluded that the ANF endocrine system might function as an effective chronic compensatory mechanism to help promote sodium and water excretion in dogs with an AV fistula through the suppression of the renin-aldosterone system and possibly through its direct renal actions.	Water	135-140	natriuretic peptide A	Canis lupus familiaris	25-28
2900825-2	1988	GGT-positive foci were produced in dose-related amounts by 0.05 and 0.2% MG in drinking water, either when administered to uninitiated rats or when given in the promotion phase.	Water	88-93	gamma-glutamyltransferase 1	Rattus norvegicus	0-3
12639118-3	2003	Addition of 30% aqueous H(2)O(2) to the methanol solution of the Mn(II) complex of L(3) ([Mn(II)L(3)(CH(3)CN)(H(2)O)](ClO(4))(2) (3)) showed a very sluggish change gradually precipitating an insoluble black gummy solid, but no dioxo-bridged manganese complex is produced.	Water	110-116	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	83-87
12639118-3	2003	Addition of 30% aqueous H(2)O(2) to the methanol solution of the Mn(II) complex of L(3) ([Mn(II)L(3)(CH(3)CN)(H(2)O)](ClO(4))(2) (3)) showed a very sluggish change gradually precipitating an insoluble black gummy solid, but no dioxo-bridged manganese complex is produced.	Water	110-116	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	96-100
3375071-2	1988	Condensation on a tetradecanucleotide template of hexa(penta)- and undecanucleotides differing only in the terminal nucleoside residue have been performed using water-soluble carbodiimide as a condensing agent.	Water	161-166	hexosaminidase subunit alpha	Homo sapiens	50-54
3036209-1	1987	The carbon kinetic isotope effect on the enzymatic dehydration of HCO3- ion is k12/k13 = 1.011 and is independent, within experimental error, of the addition of sucrose, substitution of D2O for H2O, and substitution of enzyme-bound Zn2+ by Co2+.	Water	194-197	complement C2	Homo sapiens	240-243
12595490-1	2003	The water channel aquaporin-1 (AQP1) is the molecular counterpart of the ultrasmall pore responsible for transcellular water permeability during peritoneal dialysis (PD).	Water	4-9	aquaporin 1	Rattus norvegicus	18-29
2900037-13	1988	Linear regressional analysis indicated a significant, positive, correlation between lipophilicity (log POCT/H2O) of the antagonists and the degree of antagonist pKB value underestimation on the gastric secretion assay.	Water	108-111	thymoma viral proto-oncogene 2	Mus musculus	161-164
12595490-1	2003	The water channel aquaporin-1 (AQP1) is the molecular counterpart of the ultrasmall pore responsible for transcellular water permeability during peritoneal dialysis (PD).	Water	4-9	aquaporin 1	Rattus norvegicus	31-35
12595490-1	2003	The water channel aquaporin-1 (AQP1) is the molecular counterpart of the ultrasmall pore responsible for transcellular water permeability during peritoneal dialysis (PD).	Water	119-124	aquaporin 1	Rattus norvegicus	18-29
12595490-1	2003	The water channel aquaporin-1 (AQP1) is the molecular counterpart of the ultrasmall pore responsible for transcellular water permeability during peritoneal dialysis (PD).	Water	119-124	aquaporin 1	Rattus norvegicus	31-35
2833915-4	1987	The water-soluble gp120, containing trace contaminating proteins, was purified to apparent homogeneity by preparative polyacrylamide gel electrophoresis (PAGE).	Water	4-9	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	18-23
12595490-9	2003	In conclusion, corticosteroids induce AQP1 expression in the capillary endothelium of the PM, which is reflected by increased transcellular water permeability and UF.	Water	140-145	aquaporin 1	Rattus norvegicus	38-42
12595490-10	2003	These data emphasize the critical role of AQP1 during PD and suggest that pharmacologic regulation of AQP1 may provide a target for manipulating water permeability across the PM.	Water	145-150	aquaporin 1	Rattus norvegicus	102-106
3392518-3	1988	All eggs preincubated in either CB or CD were activated upon transfer to tap water, showing cortical granule exocytosis, elevation of the chorion, and formation of a fertilization cone.	Water	77-82	transporter associated with antigen processing, subunit type c	Danio rerio	73-76
12929460-1	2003	At temperatures above and below the temperature of maximum density, TMD, for water at ambient pressure, pairs of temperatures exist at which the molar volumes of water are equal.	Water	77-82	titin	Homo sapiens	68-71
3128179-8	1988	When water attacks C-4, the 2-carbamoyl group can eliminate to form a Michael-like acceptor which adds thiols at the 2-methylene position.	Water	5-10	complement C4A (Rodgers blood group)	Homo sapiens	19-22
3570604-0	1987	GC/MS, HPLC and FAB mass spectrometric analysis of organic micropollutants in Barcelona"s water supply.	Water	90-95	FA complementation group B	Homo sapiens	16-19
3570604-4	1987	Some of the identified compounds by GC/MS and FAB mass spectrometry have not been previously reported to occur in water.	Water	114-119	FA complementation group B	Homo sapiens	46-49
12929460-1	2003	At temperatures above and below the temperature of maximum density, TMD, for water at ambient pressure, pairs of temperatures exist at which the molar volumes of water are equal.	Water	162-167	titin	Homo sapiens	68-71
12802417-1	2003	We revealed a relationship between water balance and LPO in the myocardium, liver, and blood plasma during massive blood loss and irradiation with He-Ne laser.	Water	35-40	lactoperoxidase	Rattus norvegicus	53-56
2828274-2	1987	This radiotracer has been synthesized using nucleophilic displacement of the activated nitro group of p-nitrobenzaldehyde by NCA 18F- obtained from the 18O (p, n) reaction on enriched water.	Water	184-189	CEA cell adhesion molecule 6	Homo sapiens	125-128
3291960-0	1988	Adsorption of human beta 2-microglobulin at a water/mercury interface.	Water	46-51	beta-2-microglobulin	Homo sapiens	20-40
3449867-1	1987	A water soluble paramagnetic metalloporphyrin containing Gd3+ as metal ion has been investigated by low resolution 1H NMR to evaluate the extent to which it alters the water proton relaxation times.	Water	2-7	GRDX	Homo sapiens	57-60
12582821-0	2003	pH-dependent stability of sperm whale myoglobin in water-guanidine hydrochloride solutions.	Water	51-56	myoglobin	Physeter catodon	38-47
3303451-2	1987	A single large dose of the water soluble salt of methylprednisolone significantly prolonged survival times in T-2 toxin treated animals.	Water	27-32	brachyury 2	Rattus norvegicus	110-113
2451572-7	1988	These results suggest that the development of EAU by intravitreal injection of S-Ag-specific T lymphocytes occurs by the migration of antigen-specific cells into the retina and recognition of the specific antigen, with subsequent release of soluble mediators that interact with the host effector cells, ultimately leading to specific photoreceptor damage.	Water	46-49	S-antigen visual arrestin	Rattus norvegicus	79-83
12538897-3	2003	We have developed computational tools to design water-soluble variants of helical membrane proteins, using the pentameric phospholamban (PLB) as our test case.	Water	48-53	phospholamban	Homo sapiens	137-140
3277502-3	1988	We studied effects of administering catalase, which catalyzes conversion of hydrogen peroxide to oxygen and water, to sheep subsequently infused with endotoxin to test the hypothesis that hydrogen peroxide plays a role in the pathogenesis of lung injury.	Water	108-113	catalase	Ovis aries	36-44
2962794-7	1988	In vivo, injection of such enriched suppressor cell fractions to naive syngenic rats inhibited or delayed the development of EAU following immunization with S-antigen.	Water	125-128	S-antigen visual arrestin	Rattus norvegicus	157-166
2946244-0	1986	Atrial natriuretic factor and renal function during head-out water immersion in conscious dogs.	Water	61-66	natriuretic peptide A	Canis lupus familiaris	0-25
2946244-1	1986	The potential role of atrial natriuretic factor (ANF) in the renal response to head-out water immersion (WI) was studied.	Water	88-93	natriuretic peptide A	Canis lupus familiaris	22-47
2946244-1	1986	The potential role of atrial natriuretic factor (ANF) in the renal response to head-out water immersion (WI) was studied.	Water	88-93	natriuretic peptide A	Canis lupus familiaris	49-52
12538897-4	2003	To water-solublize PLB, the membrane-exposed positions were changed to polar or charged amino acids, while the putative core was left unaltered.	Water	3-8	phospholamban	Homo sapiens	19-22
12538897-5	2003	We generated water-soluble phospholamban (WSPLB), and compared its properties to its predecessor PLB.	Water	13-18	phospholamban	Homo sapiens	44-47
12560852-1	2003	BACKGROUND: Na+/H+ exchanger (NHE) is responsible for a net uptake of sodium chloride and water from the gastrointestinal tract and maintains electrolyte and water homeostasis.	Water	90-95	solute carrier family 9 member C1	Homo sapiens	12-28
2427448-6	1986	EVLW-measurement demonstrated the lowest increase in lung water after infusion of HES; simultaneously pulmonary gas exchange was less compromised in comparison to the other infusion groups.	Water	58-63	ribosome binding protein 1	Homo sapiens	82-85
20523601-1	1988	A new method for instantaneous temperature field measurements based on LIF studies of OH, O(2), and H(2)O in an open atmospheric flame with a tunable excimer laser is suggested.	Water	100-105	LIF interleukin 6 family cytokine	Homo sapiens	71-74
3273627-1	1988	The method here described is based on the property of erythropoietin to remain in water solution in the presence of up to 60% ethanol.	Water	82-87	erythropoietin	Mus musculus	54-68
12560852-1	2003	BACKGROUND: Na+/H+ exchanger (NHE) is responsible for a net uptake of sodium chloride and water from the gastrointestinal tract and maintains electrolyte and water homeostasis.	Water	90-95	solute carrier family 9 member C1	Homo sapiens	30-33
12595880-4	2003	THM levels varied between different suppliers" water, and average THM levels were within the regulatory limits.	Water	47-52	THM	Homo sapiens	0-3
2829726-12	1988	EPR studies on reactions with water radiolysis products at cryogenic temperatures allowed us to discover that goose ceruloplasmin, like human and bovine ceruloplasmins, possesses superoxide dismutase activity.	Water	30-35	ceruloplasmin	Homo sapiens	116-129
3002455-0	1986	The use of a water-soluble carbodiimide to study the interaction between Chromatium vinosum flavocytochrome c-552 and cytochrome c.	Water	13-18	cytochrome c, somatic	Equus caballus	97-109
3002455-1	1986	The interaction between horse heart cytochrome c and Chromatium vinosum flavocytochrome c-552 was studied using the water-soluble reagent 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC).	Water	116-121	cytochrome c, somatic	Equus caballus	36-48
3266468-5	1988	The free energy of stabilization of the rhodopsin native structure is not very large and practically similar to that for native water soluble globular proteins.	Water	128-133	rhodopsin	Rattus norvegicus	40-49
12595880-5	2003	Chloroform was the predominant THM in all water types apart from the ground water of one supplier.	Water	42-47	THM	Homo sapiens	31-34
12806184-6	2003	Preincubating GEC with CYP2B1 inhibitors (piperine and cimetidine) and H(2)O(2) scavenger (pyruvate) significantly reduced H(2)O(2 )generation, preserved CYP2B1 content, prevented the increase in catalytic iron and hydroxyl radical formation including PAN-induced cytotoxicity.	Water	71-76	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	154-160
2970568-2	1988	ANF 101-126 (20 pmole/kg/min, ira) modestly reduced solute-free water clearance in water-loaded dogs and slightly lowered free water reabsorption in dehydrated animals.	Water	64-69	natriuretic peptide A	Canis lupus familiaris	0-3
2970568-2	1988	ANF 101-126 (20 pmole/kg/min, ira) modestly reduced solute-free water clearance in water-loaded dogs and slightly lowered free water reabsorption in dehydrated animals.	Water	83-88	natriuretic peptide A	Canis lupus familiaris	0-3
2970568-2	1988	ANF 101-126 (20 pmole/kg/min, ira) modestly reduced solute-free water clearance in water-loaded dogs and slightly lowered free water reabsorption in dehydrated animals.	Water	83-88	natriuretic peptide A	Canis lupus familiaris	0-3
2970568-5	1988	ANF 101-126 produced changes in free water handling which were not readily distinguishable from those induced by either hydrochlorothiazide, a distally-acting diuretic, or acetylcholine, a vasodilator.	Water	37-42	natriuretic peptide A	Canis lupus familiaris	0-3
3080992-1	1986	Water-soluble carbodiimide-catalyzed cross-linking of purified cytochrome P-450 LM2, cytochrome b5, and NADPH-cytochrome P-450 reductase was used to identify stable complexes formed between these proteins.	Water	0-5	cytochrome b5 type A	Homo sapiens	85-98
3947331-1	1986	The cholesterol esterase and lipoprotein lipase catalyzed hydrolyses of the water-soluble substrate p-nitrophenyl butyrate are competitively inhibited by butaneboronic acid and phenylboronic acid.	Water	76-81	carboxyl ester lipase	Homo sapiens	4-24
12433939-6	2002	In lung, AQP1 and AQP5 provide the principal route for osmotically driven water transport; however, alveolar fluid clearance in the neonatal and adult lung is not affected by AQP deletion nor is lung CO(2) transport or fluid accumulation in experimental models of lung injury.	Water	74-79	aquaporin 1	Mus musculus	9-13
3947331-1	1986	The cholesterol esterase and lipoprotein lipase catalyzed hydrolyses of the water-soluble substrate p-nitrophenyl butyrate are competitively inhibited by butaneboronic acid and phenylboronic acid.	Water	76-81	lipoprotein lipase	Homo sapiens	29-47
3119714-5	1987	The findings presented herein demonstrate that C3H/OuJ macrophages primed by rIFN-gamma respond to protein-free LPS (phenol-water extracted LPS), protein-rich LPS (butanol-extracted LPS), or purified LAP.	Water	124-129	interferon gamma	Rattus norvegicus	77-87
3119714-6	1987	In contrast, rIFN-gamma-primed C3H/HeJ macrophages failed to become cytolytic with phenol-water extracted LPS, but could be rendered fully tumoricidal if either butanol-extracted LPS or LAP were used as "second signals."	Water	90-95	interferon gamma	Rattus norvegicus	13-23
4044572-7	1985	However, the details of the structural relationship between the amino terminus and the catalytic network differ in the two species and the ordered water molecules thought to be either functionally or structurally important in the pancreatic enzymes are not found in the crystal structure of the phospholipase A2 from C. atrox.	Water	147-152	LOC104974671	Bos taurus	295-311
12527027-7	2002	Thirst and VP secretion in rats each are stimulated by acute arterial hypotension, albeit not by the same signals; water intake is mediated by activation of the renin-angiotensin system but not by a neural signal from arterial baroreceptors, whereas the reverse may be true for the stimulation of VP secretion.	Water	115-120	renin	Rattus norvegicus	161-166
4030968-3	1985	A water-soluble linear copolymer supporting procainamide, a ligand of the anionic site of cholinesterase, was physically entrapped at various concentrations within the gel network.	Water	2-7	butyrylcholinesterase	Homo sapiens	90-104
2960461-5	1987	In S-Ag-induced EAU many more ThS accumulated in the eye than ThP.	Water	16-19	S-antigen visual arrestin	Rattus norvegicus	3-7
12437353-7	2002	Upon phosphorylation of Ca-ATPase-bound PLB, a decreased level of solvent exposure of ANSmal is observed, suggesting that the amino acid sequence of PLB near the lipid-water interface acts as a conformational switch in response to the phosphorylation of PLB.	Water	168-173	phospholamban	Homo sapiens	40-43
3696072-7	1987	The degree of agreement between the various techniques and the NACP-water standard was quantitatively analyzed through comparison of the resulting depths of 50% dose and practical range.	Water	68-73	synuclein alpha	Homo sapiens	63-67
2820477-0	1987	Proton NMR and electrophoretic studies of the covalent complex formed by cross-linking yeast cytochrome c peroxidase and horse cytochrome c with a water-soluble carbodiimide.	Water	147-152	cytochrome c, somatic	Equus caballus	93-105
4027237-0	1985	Solvent isotope effects for lipoprotein lipase catalyzed hydrolysis of water-soluble p-nitrophenyl esters.	Water	71-76	lipoprotein lipase	Homo sapiens	28-46
4027237-1	1985	Solvent deuterium isotope effects on the rates of lipoprotein lipase (LpL) catalyzed hydrolysis of the water-soluble esters p-nitrophenyl acetate (PNPA) and p-nitrophenyl butyrate (PNPB) have been measured and fall in the range 1.5-2.2.	Water	103-108	lipoprotein lipase	Homo sapiens	50-68
4027237-1	1985	Solvent deuterium isotope effects on the rates of lipoprotein lipase (LpL) catalyzed hydrolysis of the water-soluble esters p-nitrophenyl acetate (PNPA) and p-nitrophenyl butyrate (PNPB) have been measured and fall in the range 1.5-2.2.	Water	103-108	lipoprotein lipase	Homo sapiens	70-73
4027237-5	1985	Because the pL-rate profiles are for the Vmax/Km of hydrolysis of a water-soluble substrate, the measured pKa"s are intrinsic acid-base ionization constants for a catalytically involved LpL active-site amino acid side chain.	Water	68-73	lipoprotein lipase	Homo sapiens	186-189
12437353-7	2002	Upon phosphorylation of Ca-ATPase-bound PLB, a decreased level of solvent exposure of ANSmal is observed, suggesting that the amino acid sequence of PLB near the lipid-water interface acts as a conformational switch in response to the phosphorylation of PLB.	Water	168-173	phospholamban	Homo sapiens	149-152
3110049-2	1987	These polymers were then reacted with the amino groups on myosin-specific monoclonal antibody or its Fab using a water soluble carbodiimide.	Water	113-118	FA complementation group B	Homo sapiens	101-104
12437353-7	2002	Upon phosphorylation of Ca-ATPase-bound PLB, a decreased level of solvent exposure of ANSmal is observed, suggesting that the amino acid sequence of PLB near the lipid-water interface acts as a conformational switch in response to the phosphorylation of PLB.	Water	168-173	phospholamban	Homo sapiens	149-152
12440884-2	2002	On the basis of the rate of OH- catalyzed deuterium exchange at elevated temperatures we estimate that the pKa value for ionization at C-6 of dimethyl uracil is 34 +/- 2 in water.	Water	173-178	complement C6	Homo sapiens	135-138
3123380-4	1987	Lewis rats immunized with retinal S-antigen (S-Ag) and treated for a limited time with suboptimal doses of either CsA or Dexamethasone (Dex) subsequently developed EAU.	Water	164-167	S-antigen visual arrestin	Rattus norvegicus	26-43
3123380-4	1987	Lewis rats immunized with retinal S-antigen (S-Ag) and treated for a limited time with suboptimal doses of either CsA or Dexamethasone (Dex) subsequently developed EAU.	Water	164-167	S-antigen visual arrestin	Rattus norvegicus	45-49
12485887-9	2002	Using a fluid percussion rat model that causes traumatic brain injury (TBI), it was found that VCP significantly enhances functional recovery as determined by the Morris Water Maze test.	Water	170-175	valosin-containing protein	Rattus norvegicus	95-98
3494559-2	1987	The ocular changes which characterize the EAU induced by IRBP resemble those seen in rats which develop EAU by immunization with another retinal protein, S-antigen (S-Ag).	Water	104-107	S-antigen visual arrestin	Rattus norvegicus	154-163
3494559-2	1987	The ocular changes which characterize the EAU induced by IRBP resemble those seen in rats which develop EAU by immunization with another retinal protein, S-antigen (S-Ag).	Water	104-107	S-antigen visual arrestin	Rattus norvegicus	165-169
2410196-4	1985	Assays indicate that S-antigen becomes largely water insoluble but detergent soluble under these conditions.	Water	47-52	S-antigen visual arrestin	Rattus norvegicus	21-30
4081109-5	1985	A phantom study was also performed and it was determined that MRI was superior to X-CT in its ability to detect tissue water.	Water	119-124	solute carrier family 7 member 11	Homo sapiens	82-86
3598393-1	1987	Crystals of sodium taurodeoxycholate monohydrate, NaC26H44NO6S X H2O, are trigonal, space group P3(1), with a = 18.393(1), c = 7.097(1)A, V = 2079.3(5)A3, and Z = 3.	Water	65-68	synuclein alpha	Homo sapiens	50-53
12483228-5	2002	The modeled conformation of the loop was validated by unconstrained MD simulations of the complete enzymes (CYP2C5 and CYP2B6) in water for 70 and 120 ps, respectively.	Water	130-135	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	119-125
3299396-6	1987	The increase in drinking produced by sulpiride indicates that dopamine may act at D-2 receptors to inhibit the consumption of water and hypotonic saline, but not of stronger salt solutions.	Water	126-131	solute carrier family 3 member 1	Rattus norvegicus	82-85
4008160-3	1985	The method was successfully tested with the NBS multielement water standard, SRM 1643a, and was subsequently applied to enrich Cd(II), Cr(III), Cu(II) and Pb(II) in 15 drinking water samples from Hamilton, Ontario.	Water	61-66	nibrin	Homo sapiens	44-47
12133842-1	2002	Evidence for UT-B-facilitated water transport in erythrocytes.	Water	30-35	solute carrier family 14 (urea transporter), member 1	Mus musculus	13-17
3576593-1	1987	The direct measurements of AVP during water deprivation and salt loading demonstrate the inability of the direct water deprivation test to distinguish accurately between several forms of polyuria.	Water	38-43	arginine vasopressin	Canis lupus familiaris	27-30
12133842-2	2002	We reported increased water permeability and a low urea reflection coefficient in Xenopus oocytes expressing urea transporter UT-B (former name UT3), suggesting that water and urea share a common aqueous pathway (Yang, B., and Verkman, A. S. (1998) J. Biol.	Water	166-171	solute carrier family 14 (urea transporter), member 1	Mus musculus	126-130
16663894-1	1984	The effect of water stress on glutathione reductase and catalase activities was evaluated in leaf blades of field-grown winter wheat (Triticum aestivum L.).	Water	14-19	catalase-1	Triticum aestivum	56-64
12133842-8	2002	To quantify UT-B-mediated water transport, we generated double knockout mice lacking UT-B and the major erythrocyte water channel, aquaporin-1 (AQP1).	Water	26-31	solute carrier family 14 (urea transporter), member 1	Mus musculus	12-16
12133842-12	2002	The low water permeability found in AQP1/UT-B null erythrocytes was also seen after HgCl(2) treatment of UT-B null erythrocytes or phloretin treatment of AQP1 null erythrocytes.	Water	8-13	aquaporin 1	Mus musculus	36-40
3106858-1	1987	Arginine-vasopressin (AVP) has been found to influence brain water.	Water	61-66	arginine vasopressin	Felis catus	0-20
12133842-12	2002	The low water permeability found in AQP1/UT-B null erythrocytes was also seen after HgCl(2) treatment of UT-B null erythrocytes or phloretin treatment of AQP1 null erythrocytes.	Water	8-13	solute carrier family 14 (urea transporter), member 1	Mus musculus	41-45
3106858-1	1987	Arginine-vasopressin (AVP) has been found to influence brain water.	Water	61-66	arginine vasopressin	Felis catus	22-25
6469999-3	1984	The relation between the "lipase" and "esterase" activities of the enzyme was studied using emulsified triolein and water-soluble methyl butyrate (80 mM) as substrates.	Water	116-121	lipase G, endothelial type	Rattus norvegicus	25-32
12133842-12	2002	The low water permeability found in AQP1/UT-B null erythrocytes was also seen after HgCl(2) treatment of UT-B null erythrocytes or phloretin treatment of AQP1 null erythrocytes.	Water	8-13	solute carrier family 14 (urea transporter), member 1	Mus musculus	105-109
12133842-12	2002	The low water permeability found in AQP1/UT-B null erythrocytes was also seen after HgCl(2) treatment of UT-B null erythrocytes or phloretin treatment of AQP1 null erythrocytes.	Water	8-13	aquaporin 1	Mus musculus	154-158
12133842-13	2002	The apparent activation energy for UT-B-mediated water transport was low, &lt;2 kcal/mol.	Water	49-54	solute carrier family 14 (urea transporter), member 1	Mus musculus	35-39
6548137-4	1984	High performance gel permeation chromatography and reverse-phase high performance liquid chromatography coupled with the radioimmunoassay for leumorphin have revealed that human leumorphin exists in water extracts of the human striatum.	Water	199-204	prodynorphin	Homo sapiens	178-188
12357811-1	2002	The coordinately unsaturated terbium complexes Tb.1 and Tb.2 possess two labile metal-bound water molecules that can be displaced upon metal chelation to aromatic carboxylic anions such as salicylic acid in water, which gives rise to large enhancements in the Tb(III) luminescence.	Water	92-97	receptor accessory protein 5	Homo sapiens	56-60
3803590-4	1987	ZFS titrations of PA2 vs C16-PC indicate that porcine and equine enzymes have similar binding affinity and stoichiometry, while bovine PA2 binds much more weakly to the lipid-water interfaces.	Water	175-180	LOC104974671	Bos taurus	135-138
3608428-8	1987	It is concluded that if the inhibition of pancreatic lipase by albumin is due to the inaccessibility of the enzyme to an oil-water interface blocked by denatured albumin, then albumin saturated with oleic acid would seem to be protected from unfolding at the interface and more readily displaced by the lipase.	Water	125-130	lipase G, endothelial type	Rattus norvegicus	53-59
6519027-6	1984	The patients showed normal osmoregulation of ADH release in supine, but not in upright posture: the suppression of ADH release in upright posture was only transient or incomplete despite a sufficient fall in plasma osmolality following the water load.	Water	240-245	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	115-118
12357811-1	2002	The coordinately unsaturated terbium complexes Tb.1 and Tb.2 possess two labile metal-bound water molecules that can be displaced upon metal chelation to aromatic carboxylic anions such as salicylic acid in water, which gives rise to large enhancements in the Tb(III) luminescence.	Water	207-212	receptor accessory protein 5	Homo sapiens	56-60
3560850-3	1987	The changes in the amplitudes of pulse variations produced by mechanical displacement of the walls of cerebral lateral ventricles measured with the aid of the noninvasive ultrasonic method suggest that an increase in the CSF pressure above 200 mm H2O makes the intracranial cavity too "tight", which depletes the reserve spaces of the cerebrospinal system.	Water	247-250	colony stimulating factor 2	Homo sapiens	221-224
12087110-1	2002	The major pathway for cellular uptake of the water-soluble vitamin folic acid in mammalian cells is via a plasma membrane protein known as the reduced folate carrier (RFC).	Water	45-50	solute carrier family 19 member 1	Homo sapiens	143-165
3683688-1	1987	We describe 3 patients who developed extreme hypermagnesemia due to ingestion of water of the Dead Sea, which would have been fatal were it not for the protective effects of the accompanying hypercalcemia.	Water	81-86	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	99-102
12087110-1	2002	The major pathway for cellular uptake of the water-soluble vitamin folic acid in mammalian cells is via a plasma membrane protein known as the reduced folate carrier (RFC).	Water	45-50	solute carrier family 19 member 1	Homo sapiens	167-170
6742841-4	1984	A similar incidence of tolerance to Cd2+ was demonstrated by isolates of both water types and was not associated with multiple antibiotic resistance.	Water	78-83	CD2 molecule	Homo sapiens	36-39
12403121-5	2002	These results suggest that steroids may affect water homeostasis in the rat inner ear mainly via AQP1.	Water	47-52	aquaporin 1	Rattus norvegicus	97-101
2885971-1	1987	Glycogen phosphorylase (PHO) was demonstrated immunocytochemically and enzyme histochemically in cryostat sections of liver from rats treated for 7 weeks with N-nitrosomorpholine (120 mg/l and 200 mg/l drinking water) and from untreated controls.	Water	211-216	glycogen phosphorylase L	Rattus norvegicus	0-22
6547574-2	1984	The related 2- furoylhydrazine ( FAH ) reacts at lower alkali concentrations, making this an attractive alternative carbohydrate reagent since it is (unlike PAHBAH ) freely water soluble.	Water	173-178	fumarylacetoacetate hydrolase	Homo sapiens	33-36
12181190-2	2002	Previous studies suggested that aquaporin-1 (AQP1) is an important determinant of water movement in rat cholangiocytes and that cyclic AMP mediates the movement of these water channels from cytoplasm to apical membrane, thereby increasing the osmotic water permeability.	Water	82-87	aquaporin 1	Rattus norvegicus	32-43
6587227-4	1984	The risk of acute renal failure following even brief sea water immersion is emphasised and the value of ambulant subclavian haemodialysis in the management of acute renal failure illustrated.	Water	57-62	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	53-56
3562899-3	1986	In radioimmunoassay, boiling water extracts of the neural ganglion reacted with C-terminal specific gastrin/CCK antibodies, but not N-terminal or intact G17 specific antibodies.	Water	29-34	gastrin	Homo sapiens	100-107
11539665-3	1986	A 10- to 20-bar carbon dioxide atmosphere, such as may have existed during the first several hundred million years of the earth"s history, would have had a surface temperature of approximately 85 degrees to 110 degrees C.  The early stratosphere should have been dry, thereby precluding the possibility of an oxygenic prebiotic atmosphere caused by photodissociation of water vapor followed by escape of hydrogen to space.	Water	370-375	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	0-4
6722140-5	1984	The hydraulic water permeability averaged 2.1 X 10(-2) cm/s per atm.	Water	14-19	ATM serine/threonine kinase	Homo sapiens	64-67
12181190-2	2002	Previous studies suggested that aquaporin-1 (AQP1) is an important determinant of water movement in rat cholangiocytes and that cyclic AMP mediates the movement of these water channels from cytoplasm to apical membrane, thereby increasing the osmotic water permeability.	Water	82-87	aquaporin 1	Rattus norvegicus	45-49
12181190-2	2002	Previous studies suggested that aquaporin-1 (AQP1) is an important determinant of water movement in rat cholangiocytes and that cyclic AMP mediates the movement of these water channels from cytoplasm to apical membrane, thereby increasing the osmotic water permeability.	Water	170-175	aquaporin 1	Rattus norvegicus	32-43
2947480-1	1986	This study was undertaken to define the changes in plasma levels of atrial natriuretic peptide (ANP) induced by hypertonic saline infusion followed by spontaneous water drinking and to determine whether these changes in ANP are correlated with changes in right atrial pressure (RAP) and plasma levels of vasopressin (AVP).	Water	163-168	natriuretic peptide A	Canis lupus familiaris	68-94
12181190-2	2002	Previous studies suggested that aquaporin-1 (AQP1) is an important determinant of water movement in rat cholangiocytes and that cyclic AMP mediates the movement of these water channels from cytoplasm to apical membrane, thereby increasing the osmotic water permeability.	Water	170-175	aquaporin 1	Rattus norvegicus	45-49
2947480-1	1986	This study was undertaken to define the changes in plasma levels of atrial natriuretic peptide (ANP) induced by hypertonic saline infusion followed by spontaneous water drinking and to determine whether these changes in ANP are correlated with changes in right atrial pressure (RAP) and plasma levels of vasopressin (AVP).	Water	163-168	natriuretic peptide A	Canis lupus familiaris	96-99
2947480-8	1986	These results suggest that changes in the release of ANP during increases in posM and after spontaneous water drinking are predominantly controlled by changes in RAP.	Water	104-109	natriuretic peptide A	Canis lupus familiaris	53-56
12375846-4	2002	Mass spectrometric data indicated the existence of [(H2O)nCl]-, [(H2O)nCl2]-; [(H2O)n(O2)Cl]-; [(H2O)n(O)Cl]-; and, [(H2O)n(CO2)Cl]-.	Water	53-56	nucleolin	Homo sapiens	57-60
12202385-2	2002	Using analytical ultracentrifugation and NMR methods, we show here that a membrane-soluble peptide, MS1, designed by modifying the sequence of the water-soluble coiled-coil GCN4-P1, exhibits a reversible monomer-dimer-trimer association in detergent micelles with a greater degree of cooperativity in C14-betaine than in dodecyl phosphocholine detergents.	Water	147-152	MS	Homo sapiens	100-103
3539865-2	1986	In many instances contaminated tap water has been linked to sporadic or endemic cases of human pulmonary infections, but it is not known why, in spite of frequent occurrence, legionellae only rarely cause disease.	Water	35-40	filamin B	Homo sapiens	31-34
12440767-4	2002	The other components of the respiratory-burst oxidase are water-soluble proteins of cytosolic origin, namely p67phox, p47phox, p40phox and Rac.	Water	58-63	neutrophil cytosolic factor 2	Homo sapiens	109-116
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Water	195-198	ceruloplasmin	Homo sapiens	54-67
12060659-9	2002	We suggest that high expression of RhoA contributes, through RhoA-mediated Ca(2+) sensitization, to the flaccid state of CC that can be reversed by a water-soluble, orally active Rho kinase inhibitor suitable for therapy of erectile dysfunction.	Water	150-155	transforming protein RhoA	Oryctolagus cuniculus	35-39
3741989-4	1986	It has been found that water and not the denaturant is preferentially bound in urea solutions and alkylurea solutions up to 4 M so that the Gibbs free energy of myoglobin, i.e., its chemical potential in a denaturant solution, is larger than in water.	Water	23-28	myoglobin	Homo sapiens	161-170
3741989-4	1986	It has been found that water and not the denaturant is preferentially bound in urea solutions and alkylurea solutions up to 4 M so that the Gibbs free energy of myoglobin, i.e., its chemical potential in a denaturant solution, is larger than in water.	Water	245-250	myoglobin	Homo sapiens	161-170
12060659-9	2002	We suggest that high expression of RhoA contributes, through RhoA-mediated Ca(2+) sensitization, to the flaccid state of CC that can be reversed by a water-soluble, orally active Rho kinase inhibitor suitable for therapy of erectile dysfunction.	Water	150-155	transforming protein RhoA	Oryctolagus cuniculus	61-65
12130555-7	2002	Flow cytometry demonstrated the presence of Aqps-7, -8, and -9, thus identifying candidate Aqp potentially mediating water movement into antral follicles.	Water	117-122	aquaporin 7	Homo sapiens	44-62
3706542-4	1986	In contrast, when RAP was prevented from increasing in seven dogs with a servo-controlled aortic occluder, AVP caused sustained decreases in urine volume and elevated urine osmolality from 609 +/- 27 to 1,160-1,711 mosmol/kg H2O throughout 8 days of infusion.	Water	225-228	arginine vasopressin	Canis lupus familiaris	107-110
12121434-3	2002	Furthermore, it competes with factor B for binding to C3b and C3(H2O) and promotes the dissociation of the C3bBb complex (i.e. it has decay accelerating activity).	Water	65-68	endogenous retrovirus group K member 3	Homo sapiens	54-57
3486070-4	1986	Treatment of Lewis rats with Ptx concurrent with S-Ag and CFA enhanced EAU induction as shown by an earlier onset of disease, increased severity of ocular changes, and the reduction of the threshold amount of S-Ag needed for EAU induction.	Water	71-74	S-antigen visual arrestin	Rattus norvegicus	49-53
3486070-4	1986	Treatment of Lewis rats with Ptx concurrent with S-Ag and CFA enhanced EAU induction as shown by an earlier onset of disease, increased severity of ocular changes, and the reduction of the threshold amount of S-Ag needed for EAU induction.	Water	225-228	S-antigen visual arrestin	Rattus norvegicus	49-53
3486070-4	1986	Treatment of Lewis rats with Ptx concurrent with S-Ag and CFA enhanced EAU induction as shown by an earlier onset of disease, increased severity of ocular changes, and the reduction of the threshold amount of S-Ag needed for EAU induction.	Water	225-228	S-antigen visual arrestin	Rattus norvegicus	209-213
12126624-10	2002	Cells treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to stimulate production of H(2)O(2), showed higher levels of LEDGF mRNA.	Water	97-102	PC4 and SFRS1 interacting protein 1	Homo sapiens	131-136
3007457-7	1986	These results indicate that the EF-G molecule carries a catalytic site for GTP hydrolysis, which in the absence of ribosomal particles is activated by an appropriate alcohol/water surrounding medium.	Water	174-179	G elongation factor mitochondrial 1	Homo sapiens	32-36
11978785-9	2002	Pretreatment of cardiomyocytes with a mitogen-activated protein kinase/ERK kinase (MEK) inhibitor did not suppress the MIF secretion, although it prevented the ERK1/2 activation by H(2)O(2).	Water	181-186	mitogen activated protein kinase 3	Rattus norvegicus	160-166
3488026-8	1986	In addition, the immunosuppressive effect of a water-soluble nitrosourea derivative (ACNU) was determined in terms of the cytotoxicity of spleen lymphocytes, and the restoring effect of lymphokine-activated killer (LAK) cells and/or human recombinant interleukin-2 (rIL-2) on the cytotoxicities of spleen lymphocytes were examined in ACNU-treated C57 BL/6 mice.	Water	47-52	interleukin 2	Rattus norvegicus	266-271
12090939-3	2002	After the SOD and pigment in the retina cytosol are separated, SOD activity can be quantified by water-soluble tetrazolium salt.	Water	97-102	superoxide dismutase [Cu-Zn]	Bos taurus	63-66
2937310-4	1986	In the right kidney (RK), which served as a time control, ANF increased (P less than 0.05) glomerular filtration rate (GFR) 16 +/- 4% and Na excretion (UNa V) 261 +/- 63%, whereas it decreased urine osmolality (Uosm) 36 +/- 7% without changing free water clearance.	Water	249-254	natriuretic peptide A	Canis lupus familiaris	58-61
3697472-2	1986	In the temperature range of -7 to 30 degrees C, the C(18)/PAF-H2O system is shown, upon heating, to undergo two thermal phase transitions centered at 9.2 degrees and 18.4 degrees C. The low temperature transition, attributed to the interdigitated lamellar gel (II)----gel (I) phase transition, is characterized by the breakdown of large lamellar organizations into small, but aggregated, bilayer vesicles.	Water	62-65	PCNA clamp associated factor	Homo sapiens	58-61
2430432-1	1986	Epidemiological studies in different areas in China have revealed several outstanding risk factors of PLC, i.e., HBV infection, pollution of drinking water, contamination of food by AFB1 and/or nitrosamines, and family predisposition.	Water	150-155	heparan sulfate proteoglycan 2	Homo sapiens	102-105
3741490-0	1986	Dielectric behavior of water in biological solutions: studies on myoglobin, human low-density lipoprotein, and polyvinylpyrrolidone.	Water	23-28	myoglobin	Homo sapiens	65-74
3741490-3	1986	The best interpretation of the dielectric data on the myoglobin and LDL solutions was that, in both cases, the macromolecule attracts a layer of water of hydration one or two water molecules in width.	Water	145-150	myoglobin	Homo sapiens	54-63
3741490-3	1986	The best interpretation of the dielectric data on the myoglobin and LDL solutions was that, in both cases, the macromolecule attracts a layer of water of hydration one or two water molecules in width.	Water	175-180	myoglobin	Homo sapiens	54-63
3741490-5	1986	With myoglobin, part of the water of hydration exhibits its dispersion at frequencies of a few GHz, and the rest disperses at lower frequencies, perhaps as low as 10-12 MHz.	Water	28-33	myoglobin	Homo sapiens	5-14
3741490-6	1986	The approximate constancy of the width of the hydration shell for two molecules as dissimilar in size as LDL and myoglobin confirms that the proportion of water existing as water of hydration in a biological solution depends critically on the size of the macromolecules as well as on their concentration.	Water	155-160	myoglobin	Homo sapiens	113-122
3741490-6	1986	The approximate constancy of the width of the hydration shell for two molecules as dissimilar in size as LDL and myoglobin confirms that the proportion of water existing as water of hydration in a biological solution depends critically on the size of the macromolecules as well as on their concentration.	Water	173-178	myoglobin	Homo sapiens	113-122
3817330-2	1986	Intravenous infusion of 1 clinical unit (CU; 82 pmol/kg/h) of secretin inhibited jejunal absorption of water, sodium and glucose compared to control period.	Water	103-108	SCT	Canis lupus familiaris	62-70
3817330-5	1986	Thus it seems that secretin inhibits the absorption of water, sodium and glucose from the jejunum of dogs and caerulein, added to secretin, reverses the effect of secretin.	Water	55-60	SCT	Canis lupus familiaris	19-27
20493088-1	1986	The stress of immobilization in water caused a significant increase in the activity of choline acetyltransferase (CAT) and acetylcholinesterase (AChE), acetylcholine (ACh) content in the stomach and gastric acid secretion, but a decrease of choline content in rats.	Water	32-37	acetylcholinesterase	Rattus norvegicus	145-149
3615639-1	1986	The extent to which various paramagnetic ions (Cu2+, Mn2+ and Gd3+) free and bound to human serum albumin alter the water proton relaxation times at two frequencies has been investigated.	Water	116-121	GRDX	Homo sapiens	62-65
3615639-3	1986	We found that all three ions enhance their effectiveness in inducing water proton magnetic relaxation when they are bound to human serum albumin and that Gd3+ is the most effective in pure water and Mn2+ in the presence of the protein.	Water	189-194	GRDX	Homo sapiens	154-157
2997192-2	1985	Water proton nuclear relaxation studies are consistent with the binding of Li+ to the K+ site on pyruvate kinase with an affinity of 120 mM in the absence of substrates and 16 mM in the presence of P-enolpyruvate.	Water	0-5	pyruvate kinase PKLR	Oryctolagus cuniculus	97-112
4062962-1	1985	Administration of ethanol in drinking water to Syrian golden hamsters for 1-3 weeks caused alterations of microsomal cytochrome P-450-dependent monooxygenase activities in the liver accompanied by a slight elevation in cytochrome P-450 content.	Water	38-43	cytochrome P450 2A3-like	Mesocricetus auratus	117-133
4062962-1	1985	Administration of ethanol in drinking water to Syrian golden hamsters for 1-3 weeks caused alterations of microsomal cytochrome P-450-dependent monooxygenase activities in the liver accompanied by a slight elevation in cytochrome P-450 content.	Water	38-43	cytochrome P450 2A3-like	Mesocricetus auratus	219-235
4090564-7	1985	Comparison of the total free water change in the v. portae (Mpo) with the quantity of water given (MH2O) revealed that Mpo/MH2O dropped in both series of experiments, provided that pmes was not increased by much more than 2 mm Hg (portal flow did not decrease much under normal).	Water	29-34	myeloperoxidase	Rattus norvegicus	60-63
4090564-7	1985	Comparison of the total free water change in the v. portae (Mpo) with the quantity of water given (MH2O) revealed that Mpo/MH2O dropped in both series of experiments, provided that pmes was not increased by much more than 2 mm Hg (portal flow did not decrease much under normal).	Water	29-34	myeloperoxidase	Rattus norvegicus	119-122
4090564-7	1985	Comparison of the total free water change in the v. portae (Mpo) with the quantity of water given (MH2O) revealed that Mpo/MH2O dropped in both series of experiments, provided that pmes was not increased by much more than 2 mm Hg (portal flow did not decrease much under normal).	Water	86-91	myeloperoxidase	Rattus norvegicus	119-122
4054704-1	1985	Motilin, pancreatic polypeptide and gastrin blood concentrations in response to drinking water have been studied in 40 patients with functional bowel disease and compared with results in two groups of healthy control subjects.	Water	89-94	gastrin	Homo sapiens	36-43
4052481-2	1985	Normal IgA analogous to human normal IgG and secretory IgA was shown to have horizontal orientation at air--water interface.	Water	108-113	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	7-10
4052481-2	1985	Normal IgA analogous to human normal IgG and secretory IgA was shown to have horizontal orientation at air--water interface.	Water	108-113	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	55-58
3928149-6	1985	Administration of different doses of DFMO in drinking water to B16 melanoma tumor bearing mice also resulted in an increase in tyrosinase activity and a dose dependent inhibition (86-90%) of tumor growth.	Water	54-59	tyrosinase	Mus musculus	127-137
4015102-4	1985	The exchange kinetics for apoferritin were consistent with a rapid exchange of water between the internal cavity of the protein and the bulk solvent outside the protein shell.	Water	79-84	ferritin heavy chain 1	Homo sapiens	26-37
4050027-1	1985	The kinetics of thermal denaturation of ceruloplasmin in water and in water with different percentage of D2O in the temperature range 25-85 degrees C, following the optical density change of the 610 nm charge transfer band of the protein has been investigated.	Water	57-62	ceruloplasmin	Homo sapiens	40-53
4050027-1	1985	The kinetics of thermal denaturation of ceruloplasmin in water and in water with different percentage of D2O in the temperature range 25-85 degrees C, following the optical density change of the 610 nm charge transfer band of the protein has been investigated.	Water	70-75	ceruloplasmin	Homo sapiens	40-53
3902913-4	1985	Light microscopic observation of sections incubated with tetramethyl benzidine after large injections (1 microL of a 10% solution of horseradish-peroxidase-conjugated wheat-germ lectin in water) in the dorsal column nuclei demonstrated the presence of labeled neurons in the nucleus reticularis thalami, which is not known to receive afferents from or project to these nuclei.	Water	188-193	peroxidase-like	Triticum aestivum	145-155
3871783-1	1985	A knowledge of the brain-blood partition coefficient (lambda) for water is usually required for the measurement of CBF with [15O]water.	Water	66-71	CCAAT enhancer binding protein zeta	Homo sapiens	115-118
3871783-1	1985	A knowledge of the brain-blood partition coefficient (lambda) for water is usually required for the measurement of CBF with [15O]water.	Water	129-134	CCAAT enhancer binding protein zeta	Homo sapiens	115-118
3839055-4	1985	Reverse-phase HPLC and high performance gel permeation chromatography coupled with the RIA for leumorphin revealed that human leumorphin existed together with rimorphin (dynorphin B) in water extracts of the human brain.	Water	186-191	prodynorphin	Homo sapiens	126-136
2417046-8	1985	Because agents of this class have effects other than pure central alpha-2 agonism (such as alpha-1 activity), they might have confounding and counterbalancing side effects leading to sodium and water retention.	Water	194-199	adrenoceptor alpha 1D	Homo sapiens	91-98
6513891-4	1984	A comparison of the response of these LiF dosimeters with the response of capsules given a similar dose of 60Co radiation has yielded values of 1.39 +/- 0.03 (dose to water) and 1.32 +/- 0.03 (dose to muscle) for the LiF response for 125I relative to that for 60Co.	Water	167-172	LIF interleukin 6 family cytokine	Homo sapiens	38-41
6430547-5	1984	alpha-Difluoromethylornithine given in drinking water inhibited, in a dose-dependent fashion, deoxycholate-induced ODC activity.	Water	48-53	ornithine decarboxylase 1	Rattus norvegicus	115-118
6431976-1	1984	Lipoprotein lipase, which catalyzes hydrolysis of emulsified triglycerides or water-insoluble esters, was modified with 2,4-bis(o-methoxy-polyethylene glycol)-6-chloro-s-triazine(activated PEG2).	Water	78-83	lipoprotein lipase	Homo sapiens	0-18
6383811-0	1984	Studies on equine prematurity 4: Effect of salt and water loss on the renin-angiotensin-aldosterone system in the newborn foal.	Water	52-57	renin	Equus caballus	70-75
6331221-0	1984	Detection of a bulk water structure related conformational change in horse heart cytochrome c in Cl- -H2O solutions utilizing spectrofluoroelectrochemical techniques.	Water	20-25	cytochrome c, somatic	Equus caballus	81-93
6331221-0	1984	Detection of a bulk water structure related conformational change in horse heart cytochrome c in Cl- -H2O solutions utilizing spectrofluoroelectrochemical techniques.	Water	102-105	cytochrome c, somatic	Equus caballus	81-93
6331221-11	1984	In addition, the chemical shift of the bulk water proton in tetramethylammonium chloride solution shows a nonlinearity at 42 degrees C and it is postulated that the conformational changes of cyt c are the result of the behavior of the bulk water structure.	Water	44-49	cytochrome c, somatic	Equus caballus	191-196
6331221-11	1984	In addition, the chemical shift of the bulk water proton in tetramethylammonium chloride solution shows a nonlinearity at 42 degrees C and it is postulated that the conformational changes of cyt c are the result of the behavior of the bulk water structure.	Water	240-245	cytochrome c, somatic	Equus caballus	191-196
6699018-1	1984	A water-soluble carbodiimide has been used to promote the formation of amide bonds between carboxyl residues on cytochrome b5 and lysyl residues on cytochrome b5 reductase.	Water	2-7	cytochrome b5 type A	Homo sapiens	112-125
6699018-1	1984	A water-soluble carbodiimide has been used to promote the formation of amide bonds between carboxyl residues on cytochrome b5 and lysyl residues on cytochrome b5 reductase.	Water	2-7	cytochrome b5 type A	Homo sapiens	148-161
6546696-3	1984	The cutaneous water loss was investigated in 12 patients affected with Basedow"s disease by Evaporimeter Ep-1.	Water	14-19	prostaglandin E receptor 1	Homo sapiens	105-109
6720194-3	1984	On transfer from CCl4 to chloroform, dimethyl sulfoxide, and water, the equilibrium is shifted stepwise towards the imino form, attaining a KT approximately 10 in favour of the imino species in aqueous medium.	Water	61-66	C-C motif chemokine ligand 4	Homo sapiens	17-21
6149723-3	1984	However, poorly lipid-soluble drugs, such as morphine, that tend to linger in the water phase of the CSF may spread rostrally to involve opiate receptors in brain stem nuclei.	Water	82-87	colony stimulating factor 2	Homo sapiens	101-104
6318856-1	1984	Injection of insulin to the CSF in the presence of spontaneous diuresis and hydration gives rise to the growth of reabsorption of osmotically free water accompanied by high tubular transport, as well as to the development of antinatriuresis and inhibition of diuresis.	Water	147-152	colony stimulating factor 2	Homo sapiens	28-31
6100311-7	1984	By contrast, in wild rabbits infusion of 0.9 M mannitol CSF for 2 days at 17 microliter/h caused a large reduction of water intake, a diuresis and no significant increase in salt intake.	Water	118-123	colony stimulating factor 2	Homo sapiens	56-59
6087242-2	1984	Energy yields for the synthesis of HCN and H2CO from a spark discharge were determined for various mixtures of CH4, CO, CO2, H2, H2O, N2 and NH3.	Water	129-132	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	35-38
6689399-2	1983	Gel exclusion chromatography coupled with the two RIAs showed the existence of a considerable amount of leumorphin-like peptide in water extracts from porcine neuro-intermediate pituitaries.	Water	131-136	prodynorphin	Homo sapiens	104-114
6689399-3	1983	Reverse phase high performance liquid chromatography revealed that leumorphin-like peptide in the water extracts was indistinguishable from synthetic leumorphin.	Water	98-103	prodynorphin	Homo sapiens	67-77
6618794-2	1983	Inflammatory changes, characterized by mononuclear infiltration, were found in the pineal glands of one-third of the Lewis rats that developed EAU by active immunization with S-antigen.	Water	143-146	S-antigen visual arrestin	Rattus norvegicus	175-184
6618794-5	1983	Inflammatory changes of the pineal gland also were found in rats in which EAU was induced passively by transfer of lymphocytes from S-antigen-immunized donors.	Water	74-77	S-antigen visual arrestin	Rattus norvegicus	132-141
6710516-1	1984	The effect of administration of lead in the maternal drinking water from conception to weaning on enkephalin levels in the developing rat striatum was studied between 10 and 100 days after birth.	Water	62-67	proenkephalin	Rattus norvegicus	98-108
6699007-6	1984	From these results, we propose that Hg(II) reacts with the double bond between C-5 and C-6 to form a mercuronium ion which is opened by the nucleophilic attack of water on C-6.	Water	163-168	complement C5	Homo sapiens	79-82
6706535-3	1984	In contrast, the hypertensive response to immersion in Dead Sea water was not associated with an increased natriuresis.	Water	64-69	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	60-63
6141791-0	1984	Modification of the interactions of myosin with actin and 5"-adenylyl imidodiphosphate by substitution of ethylene glycol for water.	Water	126-131	myosin heavy chain 14	Homo sapiens	36-42
6335051-5	1984	Under the enkephalin influence the inclusion of [3H]tyrosine and [14C]lisine in water-soluble and water-insoluble proteins of different cerebral structures lowered.	Water	80-85	proenkephalin	Rattus norvegicus	10-20
6335051-5	1984	Under the enkephalin influence the inclusion of [3H]tyrosine and [14C]lisine in water-soluble and water-insoluble proteins of different cerebral structures lowered.	Water	98-103	proenkephalin	Rattus norvegicus	10-20
6626552-2	1983	This hydration level, representing strongly bound water, is identical to that observed previously for human glucocerebroside (Bach, D., Sela, B. and Miller, I.R.	Water	50-55	acyl-CoA thioesterase 7	Homo sapiens	126-130
6317791-0	1983	Control of Na+ and water absorption across vertebrate "tight epithelia by adh and aldosterone.	Water	19-24	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	74-77
25024146-0	1983	Use of doubly-labeled water ((3)HH (18)O) for determination of H 2O flux and CO 2 production by a mammal in a humid environment.	Water	22-27	complement C2	Homo sapiens	63-81
6312835-5	1983	The magnitude of the conformational change is compared for cytochrome c in NaCl-H2O and NaBr-H2O solutions with the latter being larger.	Water	80-83	cytochrome c, somatic	Equus caballus	59-71
6312835-5	1983	The magnitude of the conformational change is compared for cytochrome c in NaCl-H2O and NaBr-H2O solutions with the latter being larger.	Water	93-96	cytochrome c, somatic	Equus caballus	59-71
6888365-3	1983	The participants were asked to irradiate capsules containing LiF powder to 2 Gy in 5 cm of water.	Water	91-96	LIF interleukin 6 family cytokine	Homo sapiens	61-64
6854316-4	1983	Reaction with the form HL-2 (only the amino nitrogen protonated), the dominant form of this species, proceeds by the expected rat limiting water loss (dissociative or Eigen) mechanism with rate constants of 9.3 X 10(7) M-1 sec-1 (+/- 24%) for mono and 5.1 X 10(7) M-1 sec-1 (+/- 25%) for bis complex formation.	Water	139-144	secretory blood group 1	Rattus norvegicus	223-228
6854316-4	1983	Reaction with the form HL-2 (only the amino nitrogen protonated), the dominant form of this species, proceeds by the expected rat limiting water loss (dissociative or Eigen) mechanism with rate constants of 9.3 X 10(7) M-1 sec-1 (+/- 24%) for mono and 5.1 X 10(7) M-1 sec-1 (+/- 25%) for bis complex formation.	Water	139-144	secretory blood group 1	Rattus norvegicus	268-273
6297593-1	1983	Deuterium exchangeable hyperfine proton NMR resonances of cytochrome c peroxidase (EC 1.11.1.5) are identified in H2O solutions of the enzyme.	Water	114-117	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	83-87
7169306-8	1982	4) Phosphate buffer solution and normal saline were unable to destroy the protozoa, but distilled water could destroy them like tea.	Water	98-103	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	128-131
7161181-4	1982	A water-infusion of dried sea tangle and dried shiitake was utilized for the production of M-92.	Water	2-7	ATPase H+ transporting V0 subunit e1	Homo sapiens	91-95
6298684-2	1982	Subsequent reactions of HCN with the activated nitrile groups of this HCN homopolymer would then yield heteropolyamidines, readily converted to heteropolypeptides following contact with frozen water on the surface of Titan.	Water	193-198	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	24-27
6298684-2	1982	Subsequent reactions of HCN with the activated nitrile groups of this HCN homopolymer would then yield heteropolyamidines, readily converted to heteropolypeptides following contact with frozen water on the surface of Titan.	Water	193-198	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	70-73
6298684-4	1982	Any detection of such HCN chemistry by the Voyager missions or the pending Galileo probe would constitute evidence for the hypothesis that heteropolypeptides on the primitive Earth were synthesized directly from hydrogen cyanide and water without the intervening formation of alpha-amino acids.	Water	233-238	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	22-25
7199528-8	1982	However, brief exposure of isolated membrane to distilled water releases the synemin and vimentin together in nearly pure form, before the release of significant amounts of spectrin and actin.	Water	58-63	vimentin	Homo sapiens	89-97
7117306-2	1982	Water-soluble, nonionic medium like metrizamide enables the examination of the entire CSF space.	Water	0-5	colony stimulating factor 2	Homo sapiens	86-89
6266299-1	1981	Increased concentrations of angiotensin converting enzyme (ACE) were found in lung lavages from rabbits exposed to hyperoxia for 72 h and the concentrations of ACE were correlated with ratios of extravascular lung water to body weight (r = 0.69, p less than 0.05) and albumin concentrations in lung lavages (r = 0.89, p less than 0.01).	Water	214-219	angiotensin-converting enzyme	Oryctolagus cuniculus	59-62
6266299-1	1981	Increased concentrations of angiotensin converting enzyme (ACE) were found in lung lavages from rabbits exposed to hyperoxia for 72 h and the concentrations of ACE were correlated with ratios of extravascular lung water to body weight (r = 0.69, p less than 0.05) and albumin concentrations in lung lavages (r = 0.89, p less than 0.01).	Water	214-219	angiotensin-converting enzyme	Oryctolagus cuniculus	160-163
6270682-8	1981	Analysis of the intermediate complexes showed that C5b was the subunit most exposed to water in membrane-bound C5b-7, and C5b and C8 beta were the water-exposed subunits in C5b-8.	Water	87-92	complement C5	Homo sapiens	51-54
6270682-8	1981	Analysis of the intermediate complexes showed that C5b was the subunit most exposed to water in membrane-bound C5b-7, and C5b and C8 beta were the water-exposed subunits in C5b-8.	Water	87-92	complement C5	Homo sapiens	111-114
6270682-8	1981	Analysis of the intermediate complexes showed that C5b was the subunit most exposed to water in membrane-bound C5b-7, and C5b and C8 beta were the water-exposed subunits in C5b-8.	Water	87-92	complement C5	Homo sapiens	111-114
6270682-8	1981	Analysis of the intermediate complexes showed that C5b was the subunit most exposed to water in membrane-bound C5b-7, and C5b and C8 beta were the water-exposed subunits in C5b-8.	Water	87-92	complement C5	Homo sapiens	111-114
16435474-2	1981	Secretin, caerulein, and bethanechol, the two latter against background secretin, induced similar maximal secretions of water and bicarbonate, and maximal protein outputs with the two latter were not different.	Water	120-125	SCT	Canis lupus familiaris	0-8
16435474-4	1981	In the dose interval of 10-40 microg x kg(-1) x h(-1), atropine suppressed the secretin-stimulated water and bicarbonate, but these or lower doses enhanced the response to submaximal caerulein.	Water	99-104	SCT	Canis lupus familiaris	79-87
6268402-3	1981	Although the intensity of the response was dictated by thd process water used, all induced a cytotoxic (reduction in colony-forming ability) and mutagenic (induced at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus) response in cells pretreated with dilutions of the waters and subsequent exposure to near ultraviolet light (NUV).	Water	67-72	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	171-218
6268402-3	1981	Although the intensity of the response was dictated by thd process water used, all induced a cytotoxic (reduction in colony-forming ability) and mutagenic (induced at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus) response in cells pretreated with dilutions of the waters and subsequent exposure to near ultraviolet light (NUV).	Water	67-72	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	220-225
7327614-1	1981	The immune response of adult rabbits to low concentrations of BSA in their drinking water has been a useful model to study systemic immunity initiated in gut-associated lymphoid tissue.	Water	84-89	albumin	Bos taurus	62-65
6354267-1	1983	At an intermediate stage in the hydrolysis of magnesium adenosine 5"-phosphate (MgATP) by myosin or actomyosin, there is an exchange of oxygen between water and the P gamma group of enzyme-bound nucleotide.	Water	151-156	myosin heavy chain 14	Homo sapiens	90-96
6630126-0	1983	Screening of fresh water fish extracts for enzyme-inducing substances by an aryl hydrocarbon hydroxylase induction bioassay technique.	Water	19-24	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	76-104
6664410-4	1983	Water intake, however was suppressed to a greater extent in control mice than MSG-treated mice following administration of either naloxone or fenfluramine.	Water	0-5	metastic suppressing gene	Mus musculus	78-81
12069945-1	2002	The hypothesis was tested that suppression of generation of ANG II is one of the mechanisms of the water immersion (WI)-induced natriuresis in humans.	Water	99-104	angiogenin	Homo sapiens	60-63
6305208-6	1983	These results indicate that cellular alkalinization could play a pivotal role in action of ADH, show that ADH can modify the transepithelial pH equilibrium mechanism, and suggest that intracellular pH regulation and water permeability control can be linked regulatory processes.	Water	216-221	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	91-94
6933539-2	1980	The release of 3H into body water from estradiol labeled with 3H in the 17 alpha, 16 alpha, and C-2 positions permits measurement of the rate and extent of 17 beta-ol oxidation and of the competing hydroxylations at C-2 and 16 alpha, which lead to products with different biologicaly properties.	Water	28-33	complement C2	Homo sapiens	96-99
6933539-2	1980	The release of 3H into body water from estradiol labeled with 3H in the 17 alpha, 16 alpha, and C-2 positions permits measurement of the rate and extent of 17 beta-ol oxidation and of the competing hydroxylations at C-2 and 16 alpha, which lead to products with different biologicaly properties.	Water	28-33	complement C2	Homo sapiens	216-219
6401402-1	1983	Activation energies (Ea) for water movement across vasopressin-(ADH) sensitive epithelia have been reported to be about 10 kcal/mol (1, 12).	Water	29-34	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	64-67
12100171-5	2002	We found that Nix-0699, an ethanol/water extract from indigenous plants, has a strong antisickling effect.	Water	35-40	BCL2 interacting protein 3 like	Homo sapiens	14-17
6401402-3	1983	Thus bladders equilibrated with ADH either at room temperature or at 33 degrees C and then suddenly subjected to a lower temperature were found to exhibit a marked increase in membrane permeability to water.	Water	201-206	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	32-35
6401402-8	1983	The close correlation between Ea values for bulk water viscosity and osmotic water flow across the bladder wall suggests that an equivalent number of hydrogen bonds must be broken to achieve an increase in water flow through ADH-induced channels and an increase in fluidity of water in bulk solution.	Water	49-54	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	225-228
7161327-1	1982	A specific method is presented for the assay of leucine-enkephalin (Leu-Enk) and its metabolites by reversed-phase high-performance liquid chromatography on a muBondapak C18 column with a mobile phase of methanol-water and 0.005 M tetrabutylammonium phosphate.	Water	213-218	proenkephalin	Rattus norvegicus	72-75
7351088-2	1980	The cholinesterases in blood samples, which were dried on filter papers, could be eluted with water (plasma cholinesterase) and with 1% Triton X-100 (erythrocyte acetylcholinesterase) with complete recovery of the enzyme activity.	Water	94-99	butyrylcholinesterase	Homo sapiens	4-18
22282979-9	1980	Approximately 50% of these water soluble metabolites were extractable with organic solvent upon treatment of the medium with beta-glucuronidase.	Water	27-32	glucuronidase, beta	Mus musculus	125-143
14658370-0	2002	The RowPerfect ergometer: a training aid for on-water single scull rowing.	Water	48-53	activation induced cytidine deaminase	Homo sapiens	37-40
6770337-3	1980	In animals maintained in tap water, the epithelial water permeability was reversibly inhibited by the acidification of the solution bathing the tear side of the cornea.	Water	29-34	filamin B	Homo sapiens	25-28
6770337-3	1980	In animals maintained in tap water, the epithelial water permeability was reversibly inhibited by the acidification of the solution bathing the tear side of the cornea.	Water	51-56	filamin B	Homo sapiens	25-28
6774540-0	1980	[Acetylcholinesterase and monoamine oxidase activity in hypothalamic structures during water deprivation].	Water	87-92	acetylcholinesterase	Rattus norvegicus	1-21
93026-1	1979	HLA-A and HLA-B antigens are integral membrane glycoproteins which consist of a glycosylated heavy chain embedded in the membrane in noncovalent association with beta 2-microglobulin, a water-soluble polypeptide.	Water	186-191	major histocompatibility complex, class I, B	Homo sapiens	10-15
510507-1	1979	The ingestion of 2 different water loads (7.5 and 15 ml/kg) by healthy subjects stimulated the release of plasma motilin, gastrin, pancreatic polypeptide and VIP.	Water	29-34	gastrin	Homo sapiens	122-129
17812450-0	1979	The dead sea: deepening of the mixolimnion signifies the overture to overturn of the water column.	Water	85-90	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	9-12
474764-6	1979	We conclude that AVP produces only a transient hypervolemic hypertension; that AVP is a natriuretic agent, either directly or indirectly, both acutely and chronically; and that chronically it is a more potent controller of the plasma sodium concentration than of the total body water except in extreme cases.	Water	278-283	arginine vasopressin	Canis lupus familiaris	79-82
313247-7	1979	These results indicate that alpha amylases have a substantial capacity for binding two molecules of this small substrate in a distinctive way, with the C--F glycosylic bond of one and the free C-4 hydroxyl group of the other located in the region of the enzyme"s catalytic groups, therby favoring glycosylation of the suitably positioned acceptor over solvent water.	Water	360-365	complement C4A (Rodgers blood group)	Homo sapiens	193-196
287057-1	1979	Water-soluble carbodiimide crosslinks histones 1A and 1B to histone 2A and to semi-histone A24 in chromatin from mouse cells.	Water	0-5	CD164 antigen	Mus musculus	91-94
20208831-5	1979	In this work we have treated the case of water vapor in N(2) at a total pressure of 1 atm.	Water	41-46	ATM serine/threonine kinase	Homo sapiens	86-89
17734137-3	1979	The near-freezing Ice Shelf Water produced flows northward into the Ross Sea.	Water	28-33	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	73-76
17734139-2	1979	The tritium results show that the waters below the ice have exchanged with Ross Sea water since the advent of nuclear testing.	Water	34-39	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	80-83
318532-0	1979	Linear dichroism of rhodopsin in air-water interface films.	Water	37-42	rhodopsin	Bos taurus	20-29
318532-1	1979	Air-water interface films of purified cattle rhodopsin and defined phospholipids are formed by the osmotic lysis of reconstituted membrane vesicles.	Water	4-9	rhodopsin	Bos taurus	45-54
745106-0	1978	Observations on some metabolite and hormone levels in the blood of men during simulated saturation dives to 420 metres of sea water, 43 bar, in helium-oxygen mixtures [proceedings].	Water	126-131	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	122-125
278998-2	1978	This conclusion is based on the following observations: (i) Water-soluble octamers of viral coat proteins inhibit the complement-dependent cytotoxicity of antibodies directed against H-2K and H-2D antigens in mouse cells.	Water	60-65	histocompatibility 2, K1, K region	Mus musculus	183-196
278998-3	1978	(ii) Isolated detergent-soluble HLA-A and HLA-B antigens reconstituted in lipid vesicles inhibit the binding of viral proteins to human cells (as do the water-soluble antigens to a lesser extent).	Water	153-158	major histocompatibility complex, class I, B	Homo sapiens	42-47
358496-0	1978	Antitumor activity of hot-water extract from delipidated BCG.	Water	26-31	alcohol dehydrogenase, iron containing, 1	Mus musculus	22-25
358496-1	1978	The antitumor activity of hot-water extract of delipidated BCG was investigated in mice inoculated with Sarcoma-180 cells and Ehrlich carcinoma cells, respectively.	Water	30-35	alcohol dehydrogenase, iron containing, 1	Mus musculus	26-29
358496-2	1978	The hot-water extract was found to be effective when administered after and ineffective when administered before the inoculation of tumor cells.	Water	8-13	alcohol dehydrogenase, iron containing, 1	Mus musculus	4-7
582628-4	1978	The gastrin response to ingestion of protein extract was significantly lower in patients who had been pre-treated with local anaesthetic than those who had received alkali, with or without local anaesthetic, or water.	Water	211-216	gastrin	Homo sapiens	4-11
893680-2	1977	A fact that has not been considered in previous studies dealing with urinary P(CO2) is that dissolution of HCO(3) in water results in elevation of P(CO2) which is directly proportional to the HCO(3) concentration.	Water	117-122	complement C2	Homo sapiens	77-82
893680-2	1977	A fact that has not been considered in previous studies dealing with urinary P(CO2) is that dissolution of HCO(3) in water results in elevation of P(CO2) which is directly proportional to the HCO(3) concentration.	Water	117-122	complement C2	Homo sapiens	147-152
928071-1	1977	Some peculiarities of compactization of double-stranded DNA molecules containing methylated nitrogen bases have been studied in water-salt solutions of PEG.	Water	128-133	progestagen associated endometrial protein	Homo sapiens	152-155
907349-0	1977	The diffusion-controlled reaction kinetics of the binding of CO and O2 to myoglobin in glycerol-water mixtures of high viscosity.	Water	96-101	myoglobin	Homo sapiens	74-83
404133-5	1977	At a dose of 3 nmoles, LHRH, SRIF, and TRH suppressed water intake alh.	Water	54-59	gonadotropin releasing hormone 1	Rattus norvegicus	23-27
18395-3	1977	Water extraction of the strongly basic polypeptides (pI 10.7) in R3-13 and R14 required an acidic lysis medium.	Water	0-5	ribonuclease A family member 2	Rattus norvegicus	75-78
142567-0	1977	[Use of measurement of liver cytochrome P 450 as a water toxicity test].	Water	51-56	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	29-45
265081-6	1977	Enamel fluorosis can be avoided or minimized in areas with up to at least 1.2 mgF/l water if F-supply, e.g. water-diluted gruel and/or supplementary fluoride, is not commenced until 6 months of age when body weight is higher.	Water	84-89	signal transducer and activator of transcription 5A	Homo sapiens	78-81
993201-2	1976	Detached tomato leaves, supplied with the proteinase inhibitor inducing factor (PIIF) and incubated with water under constant light, exhibited a specificity of intracellular protein turnover directed toward the selective accumulation of heat-stable proteins having disulfide corss-linkages.	Water	105-110	wound-induced proteinase inhibitor 1	Solanum lycopersicum	80-84
971429-7	1976	The main findings are: (1) quaking myelin shows a significant elevation of density in the external protein-water layer between membrane bilayers; (2) the membrane bilayer of immature myelin is approximately equal to 2 A thinner than that for normal adult; (3) the membrane bilayer of the more compact phase in trembler myelin is approximately equal to 5 A thinner than for normal; and (4) the difference in repeat periods for the two phases present in some of the trembler nerves can be accounted for predominantly by distinct membrane bilayer separations at the external boundary.	Water	107-112	quaking, KH domain containing RNA binding	Mus musculus	27-34
945070-4	1976	Dissociation constants for the Gd3+ complex of enzyme and proenzyme were evaluated from water proton relaxation rate (PRR) titrations.	Water	88-93	GRDX	Homo sapiens	31-34
1252062-7	1976	In animals, gastrin is a potent TCT secretagogue; studies in man indicate that TCT, in turn, can effect gastric acid secretion and intestinal secretion of water and electrolytes.	Water	155-160	gastrin	Homo sapiens	12-19
1191655-2	1975	Cd2+ is found to be an inhibitor on the donor side of Photosystem II and its action site, as determined by experiments using hydroxylamine and exogenous Mn, is supposed to be on the water-splitting enzyme itself.	Water	182-187	CD2 molecule	Homo sapiens	0-3
1158635-1	1975	Lenses incubated for 24 or 63 hours in media containing either lysophosphatidyl choline or phospholipase A gained Na+ ions and water.	Water	127-132	phospholipase A and acyltransferase 1	Homo sapiens	91-106
1191255-4	1975	Studies of the effects on the reaction of activators of acrosin (Ca2+, water-miscible solvents) showed that titrations carried out in barbiturate buffer containing 1M-CaCl2 and diluted with 0.2 vol.	Water	71-76	acrosin	Homo sapiens	56-63
126449-5	1975	A rapid equilibration between myosin-bound ATP and a myosin-products complex can account for the extra water oxygen incorporation of the product phosphate.	Water	103-108	myosin heavy chain 14	Homo sapiens	30-36
126449-5	1975	A rapid equilibration between myosin-bound ATP and a myosin-products complex can account for the extra water oxygen incorporation of the product phosphate.	Water	103-108	myosin heavy chain 14	Homo sapiens	53-59
124733-2	1975	The rate of release of deuterons into the body water from 2,3,4,5,6-pentadeutero-L-phenylalanine has been shown to be a valid measure of the activity of the phenylalanine hydroxylase system in vivo.	Water	47-52	phenylalanine hydroxylase	Rattus norvegicus	157-182
1161984-5	1975	), a centrally and peripherally acting acetylcholinesterase inhibitor, lowered both non-punished and punishment suppressed water intake and lick rate, whereas their quaternary analogs which primarily act in the periphery, had no significant effect at comparable dose levels.	Water	123-128	acetylcholinesterase	Rattus norvegicus	39-59
1140194-5	1975	Addition of heavy water to the perfusion fluid resulted in labelling at C-3 of lithocholic acid formed from 3-oxo-5beta-cholanoic acid, and at C-3, C-4 and C-5 of 3alpha-hydroxy-5alpha-cholanoic acid formed from 3-oxo-4-cholenoic acid.	Water	18-23	complement C5	Rattus norvegicus	156-159
7153522-1	1982	The efficiency of conjugation of mycotoxin derivatives containing a carboxylic group or other related functional groups to bovine serum albumin (BSA) by water soluble carbodiimide method, mixed anhydride method and reductive alkylation technique, improved considerably when a modified BSA was used in which the carboxylic groups in the protein were blocked by ethylenediamine (EDA).	Water	153-158	albumin	Oryctolagus cuniculus	130-143
7126597-1	1982	Reversible inhibition of butyrylcholinesterase (acylcholine acylhydrolase, EC 3.1.1.8) with several aroma hydrocarbons was investigated and the results obtained were analyzed in terms of the hydrophobic interaction, making use of the solvent-water partition coefficients for the parameterization of the hydrophobic character of the ligand molecule.	Water	242-247	butyrylcholinesterase	Homo sapiens	25-46
7126544-1	1982	The kinetics of the reaction of CO with myoglobin have been studied by laser flash photolysis in glycerol-water as a function of solvent viscosity and temperature.	Water	106-111	myoglobin	Homo sapiens	40-49
6282446-5	1982	The nature of the BaP water-soluble derivatives produced by the C3H/10T 1/2 and CVP cell lines was investigated by hydrolysis of culture medium with beta-glucuronidase and arylsulfatase.	Water	22-27	prohibitin 2	Mus musculus	18-21
6282446-6	1982	Although sulfation was not a major conjugation pathway for BaP in these cells, glucuronidation of BaP phenols was found to account for 30% of the total water-soluble derivatives.	Water	152-157	prohibitin 2	Mus musculus	98-101
18963176-3	1982	Both techniques have been applied to the NBS Standard Reference Water (SRM 1643) and some polluted water samples.	Water	64-69	nibrin	Homo sapiens	41-44
6284226-11	1982	Since Me2SO and 2H2O inhibit type I ouabain binding, it is proposed that this reaction is favored under conditions which promote loss of H2O, and E1 enzyme conformation; the stimulation of type II ouabain binding in the presence of the solvents suggests that this type of binding is favored under conditions which promote the presence of H2O at the active enzyme center and E2 enzyme conformation.	Water	17-20	enolase-phosphatase 1	Rattus norvegicus	146-155
6753094-1	1982	The urinary excretion of albumin and beta 2-microglobulin in response to two different types of oral water load was studied in 18 healthy subjects.	Water	101-106	beta-2-microglobulin	Homo sapiens	37-57
7082634-11	1982	The catalytic properties of the adsorbed enzyme suggest that substrate specificities determined for cholesterol esterase in complex reaction systems may largely reflect the availability of substrate in the appropriate physical state at the lipid-water interface.	Water	246-251	carboxyl ester lipase	Homo sapiens	100-120
6952210-1	1982	Electron micrographs are shown of the first component of human complement (C1) which has been crosslinked with a water-soluble carbodiimide to prevent dissociation into its C1q and C1r2C1s2 subunits.	Water	113-118	complement C1q A chain	Homo sapiens	173-176
6276836-2	1981	Calculations for various possible mixtures of CH4, CO2, CO, N2, H2, and H2O reveal that the prime species produced were probably HCN and NO and that the key parameter determining the rates of fixation was the ratio of C atoms to O atoms in the atmosphere.	Water	72-75	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	129-132
7309205-4	1981	During the initial days of AVP infusion in normotensive dogs, natriuresis, kaliuresis, and water retention were prominent and MAP increased progressively to a peak on Day 6 (30 mm Hg above control).	Water	91-96	arginine vasopressin	Canis lupus familiaris	27-30
7309205-8	1981	In marked contrast, cessation of AVP infusion in dogs with either AII or aldosterone hypertension was associated with a precipitous fall in MAP of 35 to 40 mm Hg within 1 hour: however, this reduction was only transient - over the subsequent hours, both salt and water retention occurred, and MAP returned to previous hypertensive levels.	Water	263-268	arginine vasopressin	Canis lupus familiaris	33-36
7255771-2	1981	(a) The pancreatic response to graded doses of synthetic secretin (water and bicarbonate outputs) was significantly reduced in calcium-treated dogs when compared with controls.	Water	67-72	SCT	Canis lupus familiaris	57-65
7013830-5	1981	With the double-headed molecular species, myosin and its water-soluble fragment heavy meromyosin, the enzyme kinetics, nucleotide and metal ion binding exhibit negative cooperativity.	Water	57-62	myosin heavy chain 14	Homo sapiens	42-48
7212084-10	1981	With fixed H2O intake, plasma AVP rose from a control of 0.8 microU/ml to an average of 1.3 microU/ml over the last 4 days of AII infusion.	Water	11-14	arginine vasopressin	Canis lupus familiaris	30-33
7212084-11	1981	A negative correlation was obtained between the "cumulative H2O balance" and plasma AVP obtained during AII infusion.	Water	60-63	arginine vasopressin	Canis lupus familiaris	84-87
6164624-11	1981	After purification on Sephadex G-15 with 0.1 M acetic acid and on the reversed-phase silicagel RP-8 with methanol/water 9:1 water soluble LIF-[1-10] was obtained in pure state as shown by thin-layer-chromatography, electrophoreses amino acid analysis and 13C-NMR spectroscopy.	Water	114-119	LIF interleukin 6 family cytokine	Homo sapiens	138-141
6164624-11	1981	After purification on Sephadex G-15 with 0.1 M acetic acid and on the reversed-phase silicagel RP-8 with methanol/water 9:1 water soluble LIF-[1-10] was obtained in pure state as shown by thin-layer-chromatography, electrophoreses amino acid analysis and 13C-NMR spectroscopy.	Water	124-129	LIF interleukin 6 family cytokine	Homo sapiens	138-141
6261300-5	1981	Addition of prostaglandins E1, E2 and I2 inhibited water flow.	Water	51-56	small nucleolar RNA, H/ACA box 73A	Homo sapiens	27-40
7340009-4	1981	Using this inhalation system and cigarettes delivering tar (total particulate matter, water and nicotine free) equal to 1, 4 and 20 mg/cigarette, it has been shown that induction of AHH in male Sprague-Dawley rat lung is an extremely sensitive system to inhaled cigarette smoke.	Water	86-91	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	182-185
7446713-3	1980	Lungs volumes, both distended with air at 30 cm H2O and with formalin at 25 cm H2O, were increased in beta APN-treated animals.	Water	48-51	alanyl aminopeptidase, membrane	Rattus norvegicus	107-110
7446713-3	1980	Lungs volumes, both distended with air at 30 cm H2O and with formalin at 25 cm H2O, were increased in beta APN-treated animals.	Water	79-82	alanyl aminopeptidase, membrane	Rattus norvegicus	107-110
6447698-1	1980	When adenosine 5"-(3-thiotriphosphate), stereospecifically labeled in the gamma position with 18O, was hydrolyzed in the presence of myosin subfragment 1 in 17O-enriched water, the product inorganic [16O,17O,18O]thiophosphate was chiral.	Water	170-175	myosin heavy chain 14	Homo sapiens	133-139
7418916-3	1980	This decrease was counteracted by the high venous and arterial pressures, but, after normalizing of hemodynamics the CSF pressure was decreased by 90-100 mm H2O as against initial level.	Water	157-160	granulocyte-macrophage colony-stimulating factor	Felis catus	117-120
7212634-5	1980	B2m (-), HLA (-) Daudi human male Burkitt lymphoma cells excreted a group of several proteins that shared the three distinctive characteristics in common; their extreme hydrophobicity, their tendency beyond saturation to form irreversibly water insoluble aggregates by extensive interchain disulfide bridges, and their conspicuously slower turn over rates compared to other Daudi excreted proteins.	Water	239-244	beta-2-microglobulin	Homo sapiens	0-3
12080470-6	2002	Indeed, the enzymatic activity of MnSOD is to transform the toxic O(2)(*)(-) in H(2)O(2).	Water	80-85	superoxide dismutase 2	Homo sapiens	34-39
1125275-0	1975	The helical content of zein, a water insoluble protein, in non-aqueous solvents.	Water	31-36	zein	Zea mays	23-27
1125275-4	1975	Though virtually insoluble in water, zein not only is a globular protein in nonaqueous solutions, but has conformational properites characteristic of more conventionally behaving globular proteins.	Water	30-35	zein	Zea mays	37-41
12089445-2	2002	Ang II actions on blood pressure regulation, water electrolyte balance, and hormone secretion are primarily mediated by AGTR1.	Water	45-50	angiotensin II receptor type 1	Homo sapiens	120-125
12083555-0	2002	Behavior of bound water in polyethylene oxide studied by DSC and high-frequency spectroscopy.	Water	18-23	desmocollin 3	Homo sapiens	57-60
1100784-4	1975	The daily water intake of the oxytocin-immunized rabbits was similar to that of control rabbits.	Water	10-15	oxytocin	Oryctolagus cuniculus	30-38
12083555-2	2002	DSC measurements show that water molecules contained in PEO are divided roughly into two species: freezable water and non-freezable water.	Water	27-32	desmocollin 3	Homo sapiens	0-3
12083555-2	2002	DSC measurements show that water molecules contained in PEO are divided roughly into two species: freezable water and non-freezable water.	Water	108-113	desmocollin 3	Homo sapiens	0-3
12083555-2	2002	DSC measurements show that water molecules contained in PEO are divided roughly into two species: freezable water and non-freezable water.	Water	108-113	desmocollin 3	Homo sapiens	0-3
12034763-1	2002	Aquaporin (AQP) water channels are expressed in the eye at sites of aqueous fluid production and outflow: AQP1 and AQP4 in nonpigmented ciliary epithelium, and AQP1 in trabecular meshwork endothelium.	Water	16-21	aquaporin 1	Mus musculus	106-110
4475743-0	1974	[Water-solubility of serum triglycerides caused by lipoprotein lipase (3)].	Water	1-6	lipoprotein lipase	Homo sapiens	51-69
7392814-0	1980	The effects of injection of water or hypertonic saline on ornithine decarboxylase activity of neonatal rat heart and brain.	Water	28-33	ornithine decarboxylase 1	Rattus norvegicus	58-81
12034763-1	2002	Aquaporin (AQP) water channels are expressed in the eye at sites of aqueous fluid production and outflow: AQP1 and AQP4 in nonpigmented ciliary epithelium, and AQP1 in trabecular meshwork endothelium.	Water	16-21	aquaporin 1	Mus musculus	160-164
16658883-4	1974	An active water-soluble crude PIIF solution was conveniently prepared from autoclaved and lyophilized tomato leaves.	Water	10-15	wound-induced proteinase inhibitor 1	Solanum lycopersicum	30-34
11978119-12	2002	Charge transfers for the hydrogen oxide bridge form Fe(2)(mu-Eta(3)Omicron(2))(H(2)O)(8)(5+) were also computed.	Water	25-39	endothelin receptor type A	Homo sapiens	61-64
6966472-10	1980	h-1 when the solution at the opposite surface was kept in 220 mosmol/kg H2O.	Water	72-75	H1.5 linker histone, cluster member	Homo sapiens	0-3
12059775-4	2002	Shielding of the ACE hydrophobic site due to the complex formation with 8-ANS or Triton X-100 resulted in pronounced stabilization of the enzyme against the action of water radiolysis products during gamma-irradiation of dilute solutions of ACE.	Water	167-172	angiotensin I converting enzyme	Bos taurus	17-20
6769091-4	1980	alpha-Glucosidase activity was measured in water homogenates, water extracts after centrifugation, and Triton extracts, with or without antisera directed against acid maltase (EC 3.2.1.3) and renal maltase (EC 3.2.1.20).	Water	43-48	sucrase-isomaltase	Homo sapiens	0-17
6769091-4	1980	alpha-Glucosidase activity was measured in water homogenates, water extracts after centrifugation, and Triton extracts, with or without antisera directed against acid maltase (EC 3.2.1.3) and renal maltase (EC 3.2.1.20).	Water	62-67	sucrase-isomaltase	Homo sapiens	0-17
5040665-8	1972	The five patients (group I) who had abnormally low concentrations of albumin in serum showed impairment of amylobarbitone metabolism; the rate constant beta(h(-1)) for the second exponential decay of serum amylobarbitone concentration was reduced (P&lt;0.01), the urinary excretion of hydroxyamylobarbitone was reduced (P&lt;0.001) and the mean serum water clearance (C, ml/min) representing amylobarbitone elimination by metabolism was reduced.5.	Water	351-356	H1.5 linker histone, cluster member	Homo sapiens	152-163
5051202-0	1972	[The effect of sodium- and calcium chloride mineral water from the Spalis spring (Druskininkai health resort) on serum pseudocholinesterase activity and the protein-synthesizing function of the liver in experimental acute toxic hepatitis].	Water	52-57	butyrylcholinesterase	Homo sapiens	119-139
12059775-4	2002	Shielding of the ACE hydrophobic site due to the complex formation with 8-ANS or Triton X-100 resulted in pronounced stabilization of the enzyme against the action of water radiolysis products during gamma-irradiation of dilute solutions of ACE.	Water	167-172	angiotensin I converting enzyme	Bos taurus	241-244
517650-5	1979	The results support the view that VIP is transmitter in the vagally induced atropine-resistant water and HCO3 secretion from the porcine pancreas.	Water	95-100	vasoactive intestinal peptide	Sus scrofa	34-37
12227387-1	2002	OBJECTIVE: The purpose of this study was to determine the localization of the aquaporin-1 (AQP1) water channel in peritoneal tissues and the effect of hyperosmolality on the peritoneal expression and function of AQP1.	Water	97-102	aquaporin 1	Rattus norvegicus	78-89
160669-1	1979	17 mineral water on the gastrin content in the blood in duodenal peptic ulcer].	Water	11-16	gastrin	Homo sapiens	24-31
4107396-0	1971	Coma due to water intoxication in beer drinkers.	Water	12-17	COMA	Homo sapiens	0-4
12227387-1	2002	OBJECTIVE: The purpose of this study was to determine the localization of the aquaporin-1 (AQP1) water channel in peritoneal tissues and the effect of hyperosmolality on the peritoneal expression and function of AQP1.	Water	97-102	aquaporin 1	Rattus norvegicus	91-95
12227387-13	2002	In addition, our findings suggested that hyperosmolality increases AQP1-dependent water permeability in peritoneal tissues by regulatIng the translocation and synthesis of AQP1 protein.	Water	82-87	aquaporin 1	Rattus norvegicus	67-71
12227387-13	2002	In addition, our findings suggested that hyperosmolality increases AQP1-dependent water permeability in peritoneal tissues by regulatIng the translocation and synthesis of AQP1 protein.	Water	82-87	aquaporin 1	Rattus norvegicus	172-176
5433466-0	1970	Contribution of the excluded volume of bovine serum albumin for solute molecules to the aprent nonsolvent water.	Water	106-111	albumin	Bos taurus	46-59
37922-0	1979	[Enzyme activity of myosin activated by different cations in a mixed H2O--D2O solvent].	Water	69-72	myosin heavy chain 14	Homo sapiens	20-26
12159957-6	2002	The estimated eta in the gels was higher than that of the free water, showing the high viscosity in the gels.	Water	63-68	endothelin receptor type A	Homo sapiens	14-17
37922-1	1979	The rate of enzymic reaction of ATP, ITP, GTP with myosin is studied in the presence of potassiu, ammonium and calcium ions in H2O--D2O solutions.	Water	127-130	myosin heavy chain 14	Homo sapiens	51-57
5458544-0	1970	[Reaction of the ciliated epithelial cells in bivalvular mollusks of the genus Teredo to changes in sea water salinity].	Water	104-109	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	100-103
21179792-6	2002	Changes of brain water contents, sodium and potassium contents were relieved by lateral ventricular injection of PACAP in the concentration of 1 x 10(-9), 1 x 10(-10) or 1 x 10(-11) mol respectively before ischemia.	Water	17-22	adenylate cyclase activating polypeptide 1	Rattus norvegicus	113-118
5435146-3	1970	A simple water-recovery test was found to be as reliable as fluoroscopy for showing that the tip of the tube was within the stomach.	Water	9-14	TOR signaling pathway regulator	Homo sapiens	93-96
471218-4	1979	Varying degrees of image degradation occur with water (simulating CSF) or metrizamide.	Water	48-53	colony stimulating factor 2	Homo sapiens	66-69
153148-1	1978	The effect of actin concentration on the myosin catalyzed exchange of phosphate oxygens with water accompanying ATP hydrolysis has been investigated.	Water	93-98	myosin heavy chain 14	Homo sapiens	41-47
5685263-1	1968	When a 3-keto bile acid methyl ester was chromatographed on basic alumina inactivated with tritiated water, the enolic hydrogen atoms at C-2 and C-4 exchanged with tritium atoms.	Water	101-106	complement C2	Homo sapiens	137-140
11929218-8	2002	The calculations support a very important role for the conserved second sphere Gln in MnSOD in specifically destabilizing coordinated H2O relative to coordinated OH-, and thus disfavouring the oxidized state of the metal ion.	Water	134-137	superoxide dismutase 2	Homo sapiens	86-91
5685263-1	1968	When a 3-keto bile acid methyl ester was chromatographed on basic alumina inactivated with tritiated water, the enolic hydrogen atoms at C-2 and C-4 exchanged with tritium atoms.	Water	101-106	complement C4A (Rodgers blood group)	Homo sapiens	145-148
6061222-0	1967	[Decontamination of river water from Sr89 and Ce-141 by domestic clays and aluminum sulfate].	Water	26-31	LUC7 like	Homo sapiens	37-41
83283-1	1978	The secondary constriction (SC) regions of human chromosomes A1, C9, and E16 were preferentially stained with Giemsa when the mitotic cells in a hypotonic solution were heated in a water bath before fixation.	Water	181-186	RNA, U105C small nucleolar	Homo sapiens	73-76
12017994-4	2002	The BET and GAB models fitted well the data of the samples in the temperature and water activity range studied.	Water	82-87	delta/notch like EGF repeat containing	Homo sapiens	4-7
743282-0	1978	The final step of side-chain cleavage of cholesterol by adrenocortical cytochrome P-450(scc) studied with [22(-18)O]20,22-dihydroxycholesterols, [18O]isocaproaldehyde, [18O]water and atmospheric [18O]oxygen.	Water	173-178	serpin family B member 3	Homo sapiens	71-91
17807292-4	1966	On this sill sea water penetrates a thick evaporite sequence to a depth of 2000 meters, and, driven by its increased density relative to sea water, flows northward to emerge in the brine-filled deeps.	Water	17-22	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	13-16
17807292-4	1966	On this sill sea water penetrates a thick evaporite sequence to a depth of 2000 meters, and, driven by its increased density relative to sea water, flows northward to emerge in the brine-filled deeps.	Water	17-22	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	137-140
17807292-4	1966	On this sill sea water penetrates a thick evaporite sequence to a depth of 2000 meters, and, driven by its increased density relative to sea water, flows northward to emerge in the brine-filled deeps.	Water	141-146	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	13-16
11786919-1	2002	The protective effects of a dietary water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi or Mannentake) mycelia (designated as MAK) against development of colon tumors were investigated in male ICR mice.	Water	36-41	male germ cell-associated kinase	Mus musculus	147-150
5891895-0	1965	The fate of Coxsackie virus A-13 in water reclamation.	Water	36-41	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	28-32
371638-0	1978	[Effect of a bicarbonate-alkaline-earth mineral water on the proteolytic and alpha-glucosidase activity of the gastric mucosa].	Water	48-53	sucrase-isomaltase	Homo sapiens	77-94
11802719-3	2002	ckshs1 and ckshs2 both have marginal thermodynamic stability (the free energies of unfolding at 25 degrees C are 3.0 and 2.5 kcal/mol, respectively) and low kinetic stability (the rates of unfolding in water are approximately 1 s(-1)).	Water	202-207	CDC28 protein kinase regulatory subunit 1B	Homo sapiens	0-6
80764-0	1978	[Usefulness of ventriculography by injecting a current water-soluble contrast media through the CSF shunt reservoir: trans-reservoiral ventriculography (author"s transl)].	Water	55-60	colony stimulating factor 2	Homo sapiens	96-99
641045-0	1978	Kinetics of oxygen-18 exchange between inorganic phosphate and water catalyzed by myosin subfragment 1, using the 18O shift in 31P NMR.	Water	63-68	myosin heavy chain 14	Homo sapiens	82-88
14325892-8	1965	A 2% inoculum in a medium composed of commercial defatted soy flakes, phosphate, and thiamine in tap water gave a satisfactory fermentation.	Water	101-106	filamin B	Homo sapiens	97-100
11961335-10	2002	The dissolution of CaF2 was faster in the carbonated drinks and in distilled water than in the non-carbonated drinks.	Water	77-82	CCR4-NOT transcription complex subunit 8	Homo sapiens	19-23
641045-1	1978	The time course of oxygen-18 exchange between [18O]Pi and normal water, catalyzed by myosin subfragment 1 in the presence of MgADP, was followed using the shift in 31P NMR caused by the presence of oxygen-18 bound to the phosphorus.	Water	65-70	myosin heavy chain 14	Homo sapiens	85-91
12097763-1	2002	BACKGROUND: Because inflammation induces oxidative stress, exhaled hydrogen peroxide (H(2)O(2)), which is a marker of oxidative stress, may be used as a non-invasive marker of airway inflammation in chronic obstructive pulmonary disease (COPD).	Water	86-91	COPD	Homo sapiens	238-242
355037-1	1978	A carcinostatic protein fraction (EPF) was separated from Escherichia coli 055 cells by the following procedure: E. coli 055 cells were suspended in distilled water, and extracted by repeater freezing and thawing.	Water	159-164	epileptiform	Mus musculus	34-37
14463295-0	1962	[Lowering the radioactivity of water polluted with Sr89 by some hydrobionts and silt].	Water	31-36	LUC7 like	Homo sapiens	51-55
11851821-2	2001	This galactoside is utilized as a substrate for the detection of the beta-galactosidase activity of coliform bacteria in water analysis.	Water	121-126	galactosidase beta 1	Homo sapiens	69-87
13823392-1	1960	New methods of intracellular turnover measurement with the aid of O-18 labelled water and the associated activation of phosphate fractions containing O-18 after proton bombardment].	Water	80-85	immunoglobulin kappa variable 1-33	Homo sapiens	66-70
922122-4	1977	Subsequently, we have analyzed the effects of osmotic and hydrostatic pressure driving forces across the cell membrane in conjuction with the mass conservation equation; we find that the change in cell volume due to the reversible movement of water out of the cell can produce one-third of the movement of the cell projection in the pipette tip.	Water	243-248	TOR signaling pathway regulator	Homo sapiens	341-344
11682148-0	2001	Intracerebroventricular injection of neuropeptide FF, an opioid modulating neuropeptide, acutely reduces food intake and stimulates water intake in the rat.	Water	132-137	pyroglutamylated RFamide peptide	Rattus norvegicus	37-49
21189-5	1977	The results show that about 70% of rhodopsin"s peptide group protons are exposed to water.	Water	84-89	rhodopsin	Bos taurus	35-44
21189-9	1977	Our results together with available information on rhodopsin suggest that a considerable length of its polypeptide chain is arranged at the surface of a channel of water penetrating into the membrane.	Water	164-169	rhodopsin	Bos taurus	51-60
893680-9	1977	In rats, dogs, and man, U-B P(CO2) was directly related to urine HCO(3) concentration and inversely related to fractional water excretion.	Water	122-127	complement C2	Homo sapiens	24-33
893680-11	1977	The observed urinary P(CO2) was very close to the P(CO2) which would be expected by simple dissolution of a comparable amount of HCO(3) in water.	Water	139-144	complement C2	Homo sapiens	21-26
13577766-0	1958	[The tissue factor in water and protein metabolism in pregnancy].	Water	22-27	coagulation factor III, tissue factor	Homo sapiens	5-18
11677212-10	2001	A polyethylene glycol drinking water solution resulted in diarrhea, higher gut-to-carcass ratios, and induction of guanylin and uroguanylin in both GC-C heterozygous and null animals.	Water	31-36	guanylate cyclase activator 2b (retina)	Mus musculus	128-139
18098543-0	1948	Isotopic analysis of the oxygen evolved by illuminated chloroplasts in normal water and in water enriched with O18.	Water	91-96	immunoglobulin kappa variable 1-33	Homo sapiens	111-114
893680-11	1977	The observed urinary P(CO2) was very close to the P(CO2) which would be expected by simple dissolution of a comparable amount of HCO(3) in water.	Water	139-144	complement C2	Homo sapiens	50-55
407936-4	1977	Other properties of the water-insoluble derivatives of papain and of similarly prepared water-insoluble conjugates of urease (EC 3.5.1.5) and cholinesterase (EC 3.1.1.8) with cellulose are also reported.	Water	88-93	butyrylcholinesterase	Homo sapiens	142-156
11765789-3	2001	With increase in w0 (water amount), the equilibrium is shifted towards the MC, protonated at -NMe2 group (MC1) and MC3 in the S0 state.	Water	21-26	melanocortin 3 receptor	Homo sapiens	115-118
15623-0	1977	A proton magnetic relaxation study of ferric myoglobin and haemoglobin in water/ethanediol solutions.	Water	74-79	myoglobin	Homo sapiens	45-54
17756096-2	1977	As an example, an apparent oxygen utilization rate of 0.20 +/- 0.02 milliliter per liter of water per year has been obtained for the Subtropical Mode water (18 degrees C water) in the Sargasso Sea.	Water	92-97	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	193-196
17756096-2	1977	As an example, an apparent oxygen utilization rate of 0.20 +/- 0.02 milliliter per liter of water per year has been obtained for the Subtropical Mode water (18 degrees C water) in the Sargasso Sea.	Water	150-155	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	193-196
19872897-5	1935	The equivalent specific resistance of the egg interior is 11 times that of sea water.	Water	79-84	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	75-78
16559488-0	1931	Fate of Fresh Water Bacteria in the Sea.	Water	14-19	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	36-39
11591153-1	2001	The binding site of the dopamine D2 receptor, like that of homologous G-protein-coupled receptors (GPCRs), is contained within a water-accessible crevice formed among its seven transmembrane segments (TMs).	Water	129-134	dopamine receptor D2	Homo sapiens	24-44
16587353-0	1928	The Interrelation between Diatoms, Their Chemical Environment, and Upwelling Water in the Sea, Off the Coast of Southern California.	Water	77-82	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	90-93
15821-2	1977	In intact animals the inhibitory effect of glucose feeding (15% glucose instead of laboratory diet and water) on the activity of liver tyrosine aminotransferase (TAT) and tryptophan pyrrolase was reconfirmed.	Water	103-108	tyrosine aminotransferase	Rattus norvegicus	135-160
15821-2	1977	In intact animals the inhibitory effect of glucose feeding (15% glucose instead of laboratory diet and water) on the activity of liver tyrosine aminotransferase (TAT) and tryptophan pyrrolase was reconfirmed.	Water	103-108	tyrosine aminotransferase	Rattus norvegicus	162-165
16586660-0	1916	On the Hydrogen Ion Concentration of Sea Water, and the Physiological Effects of the Ions of Sea Water.	Water	97-102	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	93-96
11573934-6	2001	Xenopus oocytes expressing AQP10 exhibited an increased osmotic water permeability in a mercury-sensitive manner.	Water	64-69	aquaporin 10	Homo sapiens	27-32
67228-0	1977	[Volume changes of extravascular lung water by plasma expander (HES) infusion].	Water	38-43	ribosome binding protein 1	Homo sapiens	64-67
11573934-7	2001	Although AQP10 belongs to the AQP subfamily, which has been characterized by permeability to water and neutral solutes such as urea and glycerol, it was not permeable to urea nor glycerol.	Water	93-98	aquaporin 10	Homo sapiens	9-14
836043-0	1977	Hemoglobin-water interactions in normal and sickle erythrocytes by proton magnetic resonance T1p measurements.	Water	11-16	CD5 molecule	Homo sapiens	93-96
33934761-7	2021	The good recovery values were obtained for the analysis of As3+ and Cu2+ in pool and drinking water samples.	Water	94-99	PDS5 cohesin associated factor B	Homo sapiens	59-62
11573934-8	2001	The specific expression of AQP10 suggests its contribution to the water transport in the upper portion of small intestine.	Water	66-71	aquaporin 10	Homo sapiens	27-32
11681624-1	2001	We investigated the effects of low density-lipoproteins (LDL) and lipoprotein(a) [Lp(a)] oxidized by O2*-/HO* free radicals generated by gamma radiolysis of water, on the release of tissue Plasminogen Activator (tPA) and of its main inhibitor Plaminogen Activator Inhibitor-1 (PAI-1) by human umbilical vein endothelial cells (HUVEC).	Water	157-162	lipoprotein(a)	Homo sapiens	82-87
137740-1	1977	The gamma-phosphoryl groups of two intermediates (M-ATP and M-ADP-P1) in the pathway of MgATP hydrolysis by myosin undergo extensive oxygen exchange with water.	Water	154-159	myosin heavy chain 14	Homo sapiens	108-114
11683907-0	2001	Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation.	Water	9-14	glial cell line derived neurotrophic factor	Mus musculus	108-112
861772-6	1977	With the drop in pressure distilled water or an electrolyte is forced downward inside the pipette thus filling the electiode tip.	Water	36-41	TOR signaling pathway regulator	Homo sapiens	125-128
33910729-0	2021	Water-soluble polysaccharides from Pleurotus eryngii fruiting bodies, their activity and affinity for Toll-like receptor 2 and dectin-1.	Water	0-5	C-type lectin domain containing 7A	Homo sapiens	127-135
11600024-4	2001	The calculated polychromatic quantum efficiencies (Phi(solvent)) of acifluorfen in different solvents are as follows (units are degraded molecules photon(-1)): Phi(water) = 10(-4), Phi(acetonitrile) = 10(-4), Phi(methanol) = 10(-4), and Phi(hexane) = 10(-2).	Water	164-169	glucose-6-phosphate isomerase	Homo sapiens	160-163
11600024-4	2001	The calculated polychromatic quantum efficiencies (Phi(solvent)) of acifluorfen in different solvents are as follows (units are degraded molecules photon(-1)): Phi(water) = 10(-4), Phi(acetonitrile) = 10(-4), Phi(methanol) = 10(-4), and Phi(hexane) = 10(-2).	Water	164-169	glucose-6-phosphate isomerase	Homo sapiens	160-163
11600024-4	2001	The calculated polychromatic quantum efficiencies (Phi(solvent)) of acifluorfen in different solvents are as follows (units are degraded molecules photon(-1)): Phi(water) = 10(-4), Phi(acetonitrile) = 10(-4), Phi(methanol) = 10(-4), and Phi(hexane) = 10(-2).	Water	164-169	glucose-6-phosphate isomerase	Homo sapiens	160-163
34055061-3	2021	NDI can result from genetic abnormalities, such as mutations in the vasopressin V2 receptor (AVPR2) or the aquaporin-2 (AQP2) water channel, or acquired causes, such as chronic lithium therapy.	Water	126-131	aquaporin 2	Homo sapiens	107-118
110381-0	1977	[The effect of water pressure on the gingiva during use of the water pick (author"s transl)].	Water	15-20	protein interacting with PRKCA 1	Homo sapiens	69-73
34055061-3	2021	NDI can result from genetic abnormalities, such as mutations in the vasopressin V2 receptor (AVPR2) or the aquaporin-2 (AQP2) water channel, or acquired causes, such as chronic lithium therapy.	Water	126-131	aquaporin 2	Homo sapiens	120-124
11600024-4	2001	The calculated polychromatic quantum efficiencies (Phi(solvent)) of acifluorfen in different solvents are as follows (units are degraded molecules photon(-1)): Phi(water) = 10(-4), Phi(acetonitrile) = 10(-4), Phi(methanol) = 10(-4), and Phi(hexane) = 10(-2).	Water	164-169	glucose-6-phosphate isomerase	Homo sapiens	160-163
11511225-2	2001	New rate coefficients for exchange of inner-sphere water molecules in AlF(H2O)5(2+) are kex(298) = 230(+/-20) s(-1), DeltaH(dagger) = 65(+/-3) kJ mol(-1), and DeltaS(dagger) = 19(+/-10) J mol(-1) K(-1).	Water	51-56	afamin	Homo sapiens	70-73
558940-1	1977	In anesthetized mongreal dogs, the intrarenal arterial (0.2 approximately 1.0 unit/kg-min) and the intravenous infusion (0.4 approximately 2.0 unit/kg-min) of secretin caused dose-dependent increase of RBF, accompanied by decreases of the calculated afferent arteriolar resistance (Ra) and efferent arteriolar resistance (Re), but produced no significant effect on GFR, urine flow, electrolyte excretion, osmolar clearance and free water reabsorption.	Water	432-437	SCT	Canis lupus familiaris	159-167
11511225-2	2001	New rate coefficients for exchange of inner-sphere water molecules in AlF(H2O)5(2+) are kex(298) = 230(+/-20) s(-1), DeltaH(dagger) = 65(+/-3) kJ mol(-1), and DeltaS(dagger) = 19(+/-10) J mol(-1) K(-1).	Water	74-77	afamin	Homo sapiens	70-73
11397793-11	2001	Grx1 and Grx2 were sensitive to inactivation by iodoacetamide and H(2)O(2) and exhibited similar pH dependence of catalytic activity.	Water	66-72	glutaredoxin	Homo sapiens	0-4
194233-2	1977	To overcome this problem we have extended peptides at the carboxy terminus by attachment to equine cytochrome c by a water soluble carbodiimide, relying on the acetylated N-terminus of the cytochrome to minimize its direct contribution to recovery of PTH-amino acids.	Water	117-122	cytochrome c, somatic	Equus caballus	99-111
11506936-5	2001	The characteristic different localizations of AQP1, 4 and 5 subtypes in the middle ear suggest that middle ear water homeostasis requires the coordinated operation of these AQPs.	Water	111-116	aquaporin 1	Rattus norvegicus	46-50
9969-2	1976	Intracellular pH (pHi) was measured indirectly, from the distribution of the weak, non-metabolizable organic acid 5,5-dimethyl-2,4-oxazolidinedione (DMO) between intra- and extra-cellular water.	Water	188-193	glucose-6-phosphate isomerase	Rattus norvegicus	18-21
11438937-8	2001	Water deprivation induced less increase in NPY-positive perikarya in the mediobasal hypothalamus compared to food deprivation.	Water	0-5	neuropeptide Y	Gallus gallus	43-46
32196276-1	1976	The vapor pressure of water at its triple point was measured with exceptionally high accuracy by realizing it with a special apparatus and measuring the pressure with the NBS precision mercury manometer.	Water	22-27	nibrin	Homo sapiens	171-174
1260002-2	1976	The ferric high spin myoglobin derivatives such as fluoride, water and hydroxide complexes, commonly exhibited the MCD spectra consisting of positive A terms.	Water	61-66	myoglobin	Homo sapiens	21-30
11423429-0	2001	Aplysia attractin: biophysical characterization and modeling of a water-borne pheromone.	Water	66-71	attractin	Aplysia californica	8-17
1088413-0	1976	A study of acid-base balance of CSF in connection with positive ventriculography using water soluble contrast media (Conray).	Water	87-92	colony stimulating factor 2	Homo sapiens	32-35
11416031-8	2001	Salt-loading (1% NaCl in drinking water) increased uroguanylin-mRNA expression by &gt;1.8-fold but had no effect on guanylin expression.	Water	34-39	guanylate cyclase activator 2b (retina)	Mus musculus	51-62
11412102-1	2001	The recently determined crystal structures of bacterial and bovine cytochrome c oxidases show an area of organized water within the protein immediately above the active site where oxygen chemistry occurs.	Water	115-120	LOC104968582	Bos taurus	67-79
937140-10	1976	The results support the concept that the Kal system would be involved in excretory functions dealing both with sodium and water excretion.	Water	122-127	kallikrein related-peptidase 5 like	Rattus norvegicus	41-44
11297563-4	2001	Addition of H(2)O(2) to myoglobin (Mb), followed by catalase to quench excess H(2)O(2) before the addition of LPO, still yields LPO cross-linked products.	Water	12-17	lactoperoxidase	Equus caballus	110-113
1249186-2	1976	Metabolism at the C-2 position was monitored by measuring the tritium incorporated into water in the incubate.	Water	88-93	complement C2	Homo sapiens	18-21
1200529-3	1975	When cyanocobalamin-57 Co was mixed with hog intrinsic factor in water, excretion increased to 15.6% +/- 1.6%.	Water	65-70	cobalamin binding intrinsic factor	Homo sapiens	45-61
1200529-7	1975	The classic technique in which intrinsic factor and cyanocobalamin-57 Co are mixed in water before administration should be used.	Water	86-91	cobalamin binding intrinsic factor	Homo sapiens	31-47
11297563-4	2001	Addition of H(2)O(2) to myoglobin (Mb), followed by catalase to quench excess H(2)O(2) before the addition of LPO, still yields LPO cross-linked products.	Water	12-17	lactoperoxidase	Equus caballus	128-131
11297563-4	2001	Addition of H(2)O(2) to myoglobin (Mb), followed by catalase to quench excess H(2)O(2) before the addition of LPO, still yields LPO cross-linked products.	Water	78-83	lactoperoxidase	Equus caballus	128-131
11371635-9	2001	We find that the carbonyl oxygen on the backbone of the arginine finger supplied in trans by p120GAP (Arg-789) interacts with a water molecule in the active site that is forming a bridge between the NH(2) group of the Gln-61 and the gamma-phosphate of GTP.	Water	128-133	RAS p21 protein activator 1	Homo sapiens	93-100
1237459-2	1975	A) Via complete reaction of A-chain from bovine insulin with 150 equivalents of phenylisothiocyanate in pyridine/water and trifluoroacetic acid cleavage of the resulting phenylthiocarbamoyl A-chain.	Water	113-118	insulin	Bos taurus	48-55
11337159-4	2001	In particular: (a) the BET surface area values computed from the adsorption branch vary widely and is increasing with increasing water content; (b) anomalous hysteresis of varying amplitude is observed in all cases except adsorption of krypton on the material with the lowest water content; (c) the hysteresis loops extend down to very low desorption pressure values and cannot be accounted for by capillary condensation.	Water	129-134	delta/notch like EGF repeat containing	Homo sapiens	23-26
4417532-1	1974	Bovine photoreceptor membranes have been treated with proteases to determine the accessibility of rhodopsin to these large, water soluble molecules.	Water	124-129	rhodopsin	Bos taurus	98-107
4729504-11	1973	Studies with sodium chloride indicate that a large portion of the HMGCoA synthase, which remains present in membrane subfractions derived from water-treated mitochondria, is bound by ionic interaction to component(s) of the membrane.	Water	143-148	3-hydroxy-3-methylglutaryl-CoA synthase 2	Rattus norvegicus	66-81
11337159-4	2001	In particular: (a) the BET surface area values computed from the adsorption branch vary widely and is increasing with increasing water content; (b) anomalous hysteresis of varying amplitude is observed in all cases except adsorption of krypton on the material with the lowest water content; (c) the hysteresis loops extend down to very low desorption pressure values and cannot be accounted for by capillary condensation.	Water	276-281	delta/notch like EGF repeat containing	Homo sapiens	23-26
11427334-2	2001	In addition, the effects of IVT injection of calcitonin-gene-related peptide (CGRP) on urinary water and electrolyte excretion was assessed.	Water	95-100	calcitonin-related polypeptide alpha	Rattus norvegicus	45-76
4736980-1	1973	Dilatometric studies of the structural transitions engendered in serum albumin and myoglobin as a consequence of acid-base reaction in water and in denaturing media.	Water	135-140	myoglobin	Homo sapiens	83-92
11427334-2	2001	In addition, the effects of IVT injection of calcitonin-gene-related peptide (CGRP) on urinary water and electrolyte excretion was assessed.	Water	95-100	calcitonin-related polypeptide alpha	Rattus norvegicus	78-82
16658419-12	1973	Recovery of enzyme activity was prevented by cycloheximide.Based on these results, it appears that nitrate reductase activity was affected primarily by a decrease in the rate of enzyme synthesis at low leaf water potentials.	Water	207-212	nitrate reductase [NADH] 1	Zea mays	99-116
11323233-0	2001	Surfactant protein B labelled with [(99m)Tc(CO)3(H20)3](+) retains biological activity in vitro.. UNLABELLED: Labelling of the hydrophobic surfactant protein B (SP-B) under non-reducing conditions was achieved with [(99m)Tc(CO)(3)(H2O)(3)](+) prepared according to Alberto et al.	Water	231-234	surfactant protein B	Homo sapiens	0-20
4735553-0	1973	An immobilized cholinesterase product for use in the rapid detection of enzyme inhibitors in air or water.	Water	100-105	butyrylcholinesterase	Homo sapiens	15-29
11323233-0	2001	Surfactant protein B labelled with [(99m)Tc(CO)3(H20)3](+) retains biological activity in vitro.. UNLABELLED: Labelling of the hydrophobic surfactant protein B (SP-B) under non-reducing conditions was achieved with [(99m)Tc(CO)(3)(H2O)(3)](+) prepared according to Alberto et al.	Water	231-234	surfactant protein B	Homo sapiens	139-159
11323233-0	2001	Surfactant protein B labelled with [(99m)Tc(CO)3(H20)3](+) retains biological activity in vitro.. UNLABELLED: Labelling of the hydrophobic surfactant protein B (SP-B) under non-reducing conditions was achieved with [(99m)Tc(CO)(3)(H2O)(3)](+) prepared according to Alberto et al.	Water	231-234	surfactant protein B	Homo sapiens	161-165
11300878-12	2001	By considering the contributions of the protein residues and a key water molecule to the electrostatic and van der Waals intermolecular interaction energies, a predictive and robust QSAR model for binding to type A neuraminidase was obtained.	Water	67-72	neuraminidase 1	Homo sapiens	215-228
24177639-3	1972	A permeability coefficient to water of 5.3x10(-3)cm sec(-1) has been calculated.	Water	30-35	secretory blood group 1	Rattus norvegicus	52-58
11181414-3	2001	We tested the possibility that food deprivation might affect the expression and activity of aquaporins (AQP1, 2), thereby impairing renal water reabsorption in the kidney.	Water	138-143	aquaporin 1	Rattus norvegicus	104-108
4562475-11	1972	When sea water was supplemented with 0.029 mm K(2)HPO(4) and 3.8 mm (NH(4))(2)SO(4) and inoculated with RAG-1, oil dispersion occurred within 1 day.	Water	9-14	recombination activating 1	Homo sapiens	104-109
11253941-0	2001	Preparation and characterization of hCG-loaded polylactide or poly(lactide-co-glycolide) microspheres using a modified water-in-oil-in-water (w/o/w) emulsion solvent evaporation technique.	Water	119-124	chorionic gonadotropin subunit beta 5	Homo sapiens	36-39
28370123-6	1971	The presence of 0.6 M NaCl or KCl in the sol was necessary to produce high binding quality and high water holding capacity of heated myosin B gels.	Water	100-105	myosin heavy chain 14	Homo sapiens	133-139
11253941-0	2001	Preparation and characterization of hCG-loaded polylactide or poly(lactide-co-glycolide) microspheres using a modified water-in-oil-in-water (w/o/w) emulsion solvent evaporation technique.	Water	135-140	chorionic gonadotropin subunit beta 5	Homo sapiens	36-39
5290891-0	1971	Cleft palate in CD-1 mice from restraint and deprivation of food and water.	Water	69-74	CD1 antigen complex	Mus musculus	16-20
11254213-2	2001	The water vapour adsorption isotherm for different polyaminoacids in the range of water activity varying between zero and unity apparently agreed with that expected from a type III BET isotherm.	Water	4-9	delta/notch like EGF repeat containing	Homo sapiens	181-184
11254213-2	2001	The water vapour adsorption isotherm for different polyaminoacids in the range of water activity varying between zero and unity apparently agreed with that expected from a type III BET isotherm.	Water	82-87	delta/notch like EGF repeat containing	Homo sapiens	181-184
17829431-0	1970	Mars: Detection of Atmospheric Water Vapor during the Southern Hemisphere Spring and Summer Season.	Water	31-36	methionyl-tRNA synthetase 1	Homo sapiens	0-4
17829431-1	1970	Water vapor was found to reappear in the atmosphere of Mars during its southern hemisphere spring and summer season, with a maximum vertical column abundance of 45 to 50 microns of precipitable water averaged over the entire planet.	Water	0-5	methionyl-tRNA synthetase 1	Homo sapiens	55-59
17829431-1	1970	Water vapor was found to reappear in the atmosphere of Mars during its southern hemisphere spring and summer season, with a maximum vertical column abundance of 45 to 50 microns of precipitable water averaged over the entire planet.	Water	194-199	methionyl-tRNA synthetase 1	Homo sapiens	55-59
11164231-2	2001	We propose that hCA at 5 mg ml(-1) in pure water forms head-to-tail oligomers built up, on average, by four to five monomers.	Water	43-48	HCA1	Homo sapiens	16-19
5438017-0	1970	A direct proton magnetic resonance study of Co2+ complexes with imidazole, 4-methylpyridine, pyridine, pyrimidine, and purine in water-acetone mixtures.	Water	129-134	complement C2	Homo sapiens	44-47
5415679-1	1970	There was a significant depression of the activities of intestinal lactase, invertase, and alkaline phosphatase in rats given drinking water containing 2.5 mg of colchicine per 100 ml.	Water	135-140	lactase	Rattus norvegicus	67-74
11205008-2	2001	These calculations reveal that the approach of an OH- ion leads to the formation of two distinct ion-molecule complexes: 1) the MS1 species with the hydroxide ion hydrogen bonded to the methyl group of the ester, and 2) the MS4 moiety resulting from proton abstraction of the formyl hydrogen by the hydroxide ion and formation of a three-body complex of water, methoxide ion and carbon monoxide.	Water	354-359	MS	Homo sapiens	128-131
5454838-0	1970	[Influence of some phospho-organic and chlorinated pesticides contained in water on the cholinesterase activity in the blood of warm-blooded animals].	Water	75-80	butyrylcholinesterase	Homo sapiens	88-102
33580909-0	2021	Magnetization-prepared GRASP MRI for rapid 3D T1 mapping and fat/water-separated T1 mapping.	Water	65-70	trafficking regulator and scaffold protein tamalin	Homo sapiens	23-28
11205008-2	2001	These calculations reveal that the approach of an OH- ion leads to the formation of two distinct ion-molecule complexes: 1) the MS1 species with the hydroxide ion hydrogen bonded to the methyl group of the ester, and 2) the MS4 moiety resulting from proton abstraction of the formyl hydrogen by the hydroxide ion and formation of a three-body complex of water, methoxide ion and carbon monoxide.	Water	354-359	MS4	Homo sapiens	224-227
33580909-1	2021	PURPOSE: This study aimed to (i) develop Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) MRI using a stack-of-stars trajectory for rapid free-breathing T1 mapping and (ii) extend MP-GRASP to multi-echo acquisition (MP-Dixon-GRASP) for fat/water-separated (water-specific) T1 mapping.	Water	261-266	trafficking regulator and scaffold protein tamalin	Homo sapiens	104-109
33580909-1	2021	PURPOSE: This study aimed to (i) develop Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) MRI using a stack-of-stars trajectory for rapid free-breathing T1 mapping and (ii) extend MP-GRASP to multi-echo acquisition (MP-Dixon-GRASP) for fat/water-separated (water-specific) T1 mapping.	Water	278-283	trafficking regulator and scaffold protein tamalin	Homo sapiens	104-109
5483225-0	1970	[Influence of chlorinated phenol derivatives present in water on the activity of cholinesterase and alkaline phosphatase in thermostable animals].	Water	56-61	butyrylcholinesterase	Homo sapiens	81-95
11133517-6	2001	These results indicate that the polyuria observed in Clcnk1-/- mice was water diuresis and not osmotic diuresis.	Water	72-77	chloride channel, voltage-sensitive Ka	Mus musculus	53-59
4237520-7	1969	Treatment of the cartilage residue or the water-insoluble protein polysaccharide called PPH, with neutral NH(2)OH solution releases water-soluble protein polysaccharides which in composition resemble PPL 4.	Water	42-47	enolase 1	Homo sapiens	88-91
4237520-7	1969	Treatment of the cartilage residue or the water-insoluble protein polysaccharide called PPH, with neutral NH(2)OH solution releases water-soluble protein polysaccharides which in composition resemble PPL 4.	Water	132-137	enolase 1	Homo sapiens	88-91
33580909-6	2021	The performance of MP-Dixon-GRASP for water-specific T1 mapping was evaluated in a fat/water phantom and volunteers (brain and liver).	Water	38-43	trafficking regulator and scaffold protein tamalin	Homo sapiens	28-33
33580909-11	2021	With fat/water-separated T1 estimation, MP-Dixon-GRASP could be potentially useful for imaging patients with fatty-liver diseases.	Water	9-14	trafficking regulator and scaffold protein tamalin	Homo sapiens	49-54
11181968-6	2001	EP1 and EP3 mRNA expression predominates in the collecting duct and thick limb, respectively, where their stimulation reduces NaCl and water absorption, promoting natriuresis and diuresis.	Water	135-140	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	8-11
5346791-0	1969	[Inhibiting action of oxytocin on the net epithelial transport of water in the rabbit gallbladder].	Water	66-71	oxytocin	Oryctolagus cuniculus	22-30
5371923-0	1969	[Drinking water supply of a North Sea island (Wangerooge) by shoal-displaced plastic pipe-lines and their problems].	Water	10-15	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	34-37
11336352-1	2001	PURPOSE: The purpose of this study was to determine the distribution and diffusion of sodium taurocholate-phospholipid micelles with mucin in order to provide the foundation for understanding the transport of ingested fat and poorly water-soluble drugs through the intestinal mucous layer.	Water	233-238	mucin 1, cell surface associated	Bos taurus	133-138
5745580-0	1968	[The effect of retrograde introduction of a preparation of hyaluronidase and lysozyme on the reabsorption of osmotically free water in the dog kidney].	Water	126-131	lysozyme	Canis lupus familiaris	77-85
11336352-10	2001	Mucin decreased the diffusivity of water and the phospholipids, but the effect was relatively small.	Water	35-40	mucin 1, cell surface associated	Bos taurus	0-5
11464767-5	2001	38% (9/24) raw water and 23% (10/44) tap water samples were positive for at least one virus marker with 9/10 positive tap water samples complying with bacterial criteria.	Water	41-46	tracheal antimicrobial peptide	Bos taurus	37-40
18960377-0	1968	Determination of scandium in sea-water by atomic-absorption spectroscopy.	Water	33-38	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	29-32
11730133-8	2001	Due to reduced water usage, both COD and salt concentrations tend to increase for industrial effluents.	Water	15-20	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	33-36
18960377-1	1968	A method for the determination of scandium in sea-water at the sub-microgram level has been developed.	Water	50-55	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	46-49
5689153-0	1968	Effect of a synthetic gastrin-like pentapeptide upon the intestinal transport of sodium, potassium, and water.	Water	104-109	gastrin	Homo sapiens	22-29
11121027-6	2000	The pH profiles of this catalysis and the catalyzed hydrolysis of 4-nitrophenylacetate indicate that the pK(a) of the zinc-bound water in CA XII is 7.1.	Water	129-134	carbonic anhydrase 12	Homo sapiens	138-144
17829745-0	1965	Silicates: Reactivity with Sea Water.	Water	31-36	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	27-30
5854087-0	1965	[Kinetics of the inclusion of O-18 from heavy oxygen water into the molecule of violaxanthine].	Water	53-58	immunoglobulin kappa variable 1-33	Homo sapiens	30-34
10942779-9	2000	The enzymatic hydrolysis of the ganglioside GM1 is catalyzed by beta-galactosidase, a water-soluble acid exohydrolase.	Water	86-91	galactosidase beta 1	Homo sapiens	64-82
17790803-0	1964	Electrolytic Conductance of Sea Water: Effect of Calcium Carbonate Dissolution.	Water	32-37	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	28-31
17790803-1	1964	Calcium carbonate dissolution in the presence of excess carbon dioxide increased the specific conductance of sea water by approximately 6 x 10(-5) ohm(-1)cm(-1) per millimole of carbonate dissolved.	Water	113-118	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
17790803-2	1964	The observed conductance increase can be explained by the partial equivalent conductance of calcium bicarbonate and by the hindrance effect of uncharged carbon dioxide dissolved in sea water.	Water	185-190	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	181-184
14219034-6	1964	1964.-Treatment of a phenol-water preparation of C(14)-labeled Escherichia coli O91-H21 endotoxin of low solubility with lysozyme at pH 5.0 or 8.0 effected a dissociation of the preparation.	Water	28-33	lysozyme C-like	Oryctolagus cuniculus	121-129
11017751-3	2000	However, the activation energies of desorption for chemisorbed water varied from approximately 80 to &gt;247 kJ/mol for fumed silica, Cab-O-Sil-M-7D, and approximately 96 to 155 kJ/mol for precipitated silica, Hi-Sil-233.	Water	63-68	STIL centriolar assembly protein	Homo sapiens	140-143
17746008-1	1963	Chemical studies indicate that during the first half of the history of Lake Zeribar, since about 14,800 years ago, the outlet ran very intermittently, thus resulting in a carbonate deposition and a moderate chloride content of the water.	Water	231-236	RAN, member RAS oncogene family	Homo sapiens	126-129
11017751-3	2000	However, the activation energies of desorption for chemisorbed water varied from approximately 80 to &gt;247 kJ/mol for fumed silica, Cab-O-Sil-M-7D, and approximately 96 to 155 kJ/mol for precipitated silica, Hi-Sil-233.	Water	63-68	STIL centriolar assembly protein	Homo sapiens	213-216
32196239-2	1961	These data, combined with the heats of formation of boric acid, carbon dioxide, and water give -34.79 +-5.40, -47.2 +-3.7, and -83.2 +-2.5 kcal/mole at 25  C for the standard heats of formation of trimethylborane, triethylborane, and tri-n-butylborane, respectively.	Water	84-89	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	197-200
11017751-6	2000	Most of the chemisorbed water with activation energies &lt;126 kJ/mol can be pumped away in a matter of days in a good vacuum environment at 500 K. We had previously measured about 0.1-0.4 wt% of water in silica-reinforced polysiloxane formulations containing approximately 21% Cab-O-Sil-M-7D and approximately 4% Hi-Sil-233.	Water	24-29	STIL centriolar assembly protein	Homo sapiens	284-287
11017751-6	2000	Most of the chemisorbed water with activation energies &lt;126 kJ/mol can be pumped away in a matter of days in a good vacuum environment at 500 K. We had previously measured about 0.1-0.4 wt% of water in silica-reinforced polysiloxane formulations containing approximately 21% Cab-O-Sil-M-7D and approximately 4% Hi-Sil-233.	Water	24-29	STIL centriolar assembly protein	Homo sapiens	317-320
13684982-0	1961	Equilibrium constants of phosphoryl transfer from C-1 to C-6 of alpha-D-glucose 1-phosphate and from glucose 6-phosphate to water.	Water	124-129	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	50-60
11017751-6	2000	Most of the chemisorbed water with activation energies &lt;126 kJ/mol can be pumped away in a matter of days in a good vacuum environment at 500 K. We had previously measured about 0.1-0.4 wt% of water in silica-reinforced polysiloxane formulations containing approximately 21% Cab-O-Sil-M-7D and approximately 4% Hi-Sil-233.	Water	196-201	STIL centriolar assembly protein	Homo sapiens	284-287
11017751-6	2000	Most of the chemisorbed water with activation energies &lt;126 kJ/mol can be pumped away in a matter of days in a good vacuum environment at 500 K. We had previously measured about 0.1-0.4 wt% of water in silica-reinforced polysiloxane formulations containing approximately 21% Cab-O-Sil-M-7D and approximately 4% Hi-Sil-233.	Water	196-201	STIL centriolar assembly protein	Homo sapiens	317-320
11041560-13	2000	The LPS-induced decreases in food intake, body mass and water intake were significantly attenuated by the treatment with TNF bp.	Water	56-61	tumor necrosis factor-like	Rattus norvegicus	121-124
13733625-0	1961	[Action of an electropositive colloid (lysozyme) on the urinary excretion of water and electrolytes in the rabbit].	Water	77-82	lysozyme C-like	Oryctolagus cuniculus	39-47
10974048-4	2000	The elastic modulus of chicken apoA-IV at the air/water interface was 13.7 mN/m, versus 21.7 mN/m for human apoA-IV and 7.6 mN/m for apoA-I.	Water	50-55	apolipoprotein A4	Gallus gallus	31-38
13475377-0	1957	The role of water in enzymatic hydrolysis; general method and its application to myosin.	Water	12-17	myosin heavy chain 14	Homo sapiens	81-87
10967554-1	2000	The rapid effect of 1 alpha,25(OH(2))-vitamin D(3) [1 alpha, 25(OH(2))D(3)] on tyrosine kinase Src and its relationship to the vitamin D receptor (VDR) was investigated to further characterize the hormone signaling mechanism in chick muscle cells.	Water	31-37	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	127-145
14849990-0	1951	[Therapeutic effect of sea water drinking during health cures at the North Sea].	Water	27-32	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	23-26
14849990-0	1951	[Therapeutic effect of sea water drinking during health cures at the North Sea].	Water	27-32	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	75-78
10967554-1	2000	The rapid effect of 1 alpha,25(OH(2))-vitamin D(3) [1 alpha, 25(OH(2))D(3)] on tyrosine kinase Src and its relationship to the vitamin D receptor (VDR) was investigated to further characterize the hormone signaling mechanism in chick muscle cells.	Water	31-37	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	147-150
10916093-13	2000	CONCLUSIONS: CP-induced polyuria in rats is associated with a significant decrease in the expression of collecting duct (AQP2 and AQP3) and proximal nephron and microvascular (AQP1) water channels in the inner medulla.	Water	182-187	aquaporin 1	Rattus norvegicus	176-180
33938359-9	2021	Thus, this RSN system developed with distilled water and meglumine is recommended as an oral water-soluble rebamipide-loaded pharmaceutical product.	Water	47-52	CAP-GLY domain containing linker protein 1	Rattus norvegicus	11-14
33938359-9	2021	Thus, this RSN system developed with distilled water and meglumine is recommended as an oral water-soluble rebamipide-loaded pharmaceutical product.	Water	93-98	CAP-GLY domain containing linker protein 1	Rattus norvegicus	11-14
10898598-10	2000	POCl(3) on reaction with water and HOP(O)Cl(2) have the same potency for inhibition of AChE from either electric eel or housefly head as well as the same toxicity for mice.	Water	25-30	acetylcholinesterase	Mus musculus	87-91
33618302-2	2021	Produced water (PW), which is the largest byproduct of oil and gas production, is a complex mixture of dissolved and undissolved organic and inorganic substances.	Water	9-14	gastrin	Homo sapiens	63-66
10841807-3	2000	In this work, models have been constructed considering some implicit water molecules, placed in the position suggested by GRID, that participate in the dynamic hydrogen-bonding network at the polar active site entrance together with protein residues 355, 524, 120, and 513.	Water	69-74	GRB2 related adaptor protein 2	Homo sapiens	122-126
33685369-5	2021	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.	Water	84-89	LAP	Homo sapiens	65-68
10781416-6	2000	Osmotically driven water permeability between the air space and capillary compartments is reduced approximately 10-fold by deletion of AQP1 or AQP5 and reduced even more by deletion of AQP1 and AQP4 or AQP1 and AQP5 together.	Water	19-24	aquaporin 1	Mus musculus	135-139
33667879-1	2021	The present study aimed to investigate the impact of the degradation of cytoskeletal proteins (desmin, integrin, vinculin, and talin) on the formation of intracellular gap and drip channel and water-holding capacity in pork.	Water	193-198	desmin	Homo sapiens	95-101
33545467-1	2021	In the San Joaquin Valley (SJV), California, about 10% of drinking water wells since 2010 had arsenic concentrations above the US maximum contaminant level of 10 mug/L.	Water	67-72	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	7-10
10781416-6	2000	Osmotically driven water permeability between the air space and capillary compartments is reduced approximately 10-fold by deletion of AQP1 or AQP5 and reduced even more by deletion of AQP1 and AQP4 or AQP1 and AQP5 together.	Water	19-24	aquaporin 1	Mus musculus	185-189
10781416-6	2000	Osmotically driven water permeability between the air space and capillary compartments is reduced approximately 10-fold by deletion of AQP1 or AQP5 and reduced even more by deletion of AQP1 and AQP4 or AQP1 and AQP5 together.	Water	19-24	aquaporin 1	Mus musculus	185-189
10781416-7	2000	AQP1 deletion greatly reduces osmotically driven water transport across alveolar capillaries but has only a minor effect on hydrostatic lung filtration, which primarily involves paracellular water movement.	Water	49-54	aquaporin 1	Mus musculus	0-4
10781416-7	2000	AQP1 deletion greatly reduces osmotically driven water transport across alveolar capillaries but has only a minor effect on hydrostatic lung filtration, which primarily involves paracellular water movement.	Water	191-196	aquaporin 1	Mus musculus	0-4
10839360-5	2000	This suggests EphB2 may regulate ionic homeostasis and endolymph fluid production through macromolecular associations with membrane channels that transport chloride, bicarbonate, and water.	Water	183-188	Eph receptor B2	Mus musculus	14-19
11980098-6	2000	Regional cerebral blood flow (rCBF) was measured by positron emission tomography (PET) using the 15O-labeled water autoradiographic method with simultaneous recording of lumbar CSFP.	Water	109-114	CCAAT/enhancer binding protein zeta	Rattus norvegicus	30-34
34043073-5	2021	The water stabilities of CsPb(BrI)3@Asp-Cs4Pb(BrI)6 and CsPbBr3@Asp-Cs4PbBr6 were greatly improved too.	Water	4-9	granzyme B	Homo sapiens	25-29
10760363-10	2000	PD 158771 produced anxiolytic-like effects in the water-lick (Vogel) conflict test, effects possibly due to the 5-HT(1A) activity.	Water	50-55	5-hydroxytryptamine receptor 1A	Rattus norvegicus	112-119
34051663-9	2021	Furthermore, nano-Cu, micro-Cu, and CuCl2.2 H2O upregulated the expression of the autophagy-related proteins, Beclin-1 and LC3 II/ LC3 I, and downregulated that of p62.	Water	44-47	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	123-136
10753942-4	2000	Syncollin has intramolecular disulfide bonds and was accessible to water-soluble cross-linking and biotinylating reagents only when granules were lysed by sonication.	Water	67-72	syncollin	Homo sapiens	0-9
34018392-5	2021	8-Oxo-G is recognized by Gln315 of hOGG1 mainly through hydrogen bonds mediated by continuous exchange of 2 water molecules.	Water	108-113	8-oxoguanine DNA glycosylase	Homo sapiens	35-40
10807425-10	2000	CONCLUSIONS: A water extract of H. pylori increased both proliferation and apoptosis, which are related to exacerbation and healing of ulcer as well as appearance of connexin 32.	Water	15-20	gap junction protein, beta 1	Rattus norvegicus	166-177
34013512-3	2021	Activation of TLR4 in NP cells leads to significant, persistent changes in cell biophysical properties, including hydraulic permeability and osmotically active water content, as well as alterations to the actin cytoskeleton.	Water	160-165	toll like receptor 4	Bos taurus	14-18
34013304-0	2021	SANS quantification of bound water in water-soluble polymers across multiple concentration regimes.	Water	29-34	USH1 protein network component sans	Homo sapiens	0-4
34013304-0	2021	SANS quantification of bound water in water-soluble polymers across multiple concentration regimes.	Water	38-43	USH1 protein network component sans	Homo sapiens	0-4
10777648-0	2000	Electrochemical Oxidation of Water to Dioxygen Catalyzed by the Oxidized Form of the Bis(ruthenium - hydroxo) Complex in H(2)O This work was partly supported by the Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports, and Culture of Japan (No.	Water	29-34	activation induced cytidine deaminase	Homo sapiens	174-177
34013304-1	2021	Contrast-variation small-angle neutron scattering (CV-SANS) is a widely used technique for quantifying hydration water in soft matter systems, but it is predominantly applied in the dilute regime or for systems with a well-defined structure factor.	Water	113-118	USH1 protein network component sans	Homo sapiens	54-58
34013304-2	2021	Here, CV-SANS was used to quantify the number of hydration water molecules associating with three water-soluble polymers with different critical solution temperatures and types of water-solute interactions in dilute, semidilute, and concentrated solution through the exploration of novel methods of data fitting and analysis.	Water	59-64	USH1 protein network component sans	Homo sapiens	9-13
34013304-2	2021	Here, CV-SANS was used to quantify the number of hydration water molecules associating with three water-soluble polymers with different critical solution temperatures and types of water-solute interactions in dilute, semidilute, and concentrated solution through the exploration of novel methods of data fitting and analysis.	Water	98-103	USH1 protein network component sans	Homo sapiens	9-13
34013304-2	2021	Here, CV-SANS was used to quantify the number of hydration water molecules associating with three water-soluble polymers with different critical solution temperatures and types of water-solute interactions in dilute, semidilute, and concentrated solution through the exploration of novel methods of data fitting and analysis.	Water	98-103	USH1 protein network component sans	Homo sapiens	9-13
34013304-10	2021	This SANS-based method to count hydration water molecules can be applied to polymers in any concentration regime, which will lead to improved understanding of water-polymer interactions and their impact on materials design.	Water	42-47	USH1 protein network component sans	Homo sapiens	5-9
34013304-10	2021	This SANS-based method to count hydration water molecules can be applied to polymers in any concentration regime, which will lead to improved understanding of water-polymer interactions and their impact on materials design.	Water	159-164	USH1 protein network component sans	Homo sapiens	5-9
10786005-5	2000	Cr3+ ions along with Fe2+ and Fe3+ are then removed mainly by precipitation as Cr(OH)3, Fe(OH)2, and Fe(OH)3 near the cathode where OH- ions are generated by water electrolysis.	Water	158-163	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	0-3
33705801-7	2021	Similarly, acute morphine tolerance in vivo in beta-arrestin-2 knockout mice was prevented in the warm-water tail-withdrawal assay.	Water	103-108	arrestin, beta 2	Mus musculus	47-62
10805445-6	2000	LIMP 2 is a multifunctional aquaglyceroporin, and displays the ability to flux both water as well as glycerol upon expression in Xenopus oocytes.	Water	84-89	LIMP2	Lotus japonicus	0-6
34056617-5	2021	We compare them with previous data for PEG/PEO in water and PDMS in ethyl acetate.	Water	50-55	progestagen associated endometrial protein	Homo sapiens	39-42
10722845-3	2000	hIAPP in trifluoroethanol or hexafluoro-2-isopropanol (HFIP) diluted in water or phosphate buffer (PB) exhibited random structure which was converted to beta-sheet and fibrils with time.	Water	72-77	islet amyloid polypeptide	Homo sapiens	0-5
34000310-5	2021	The addition of NCF at 1.5% weight of starch increased the tensile strength (TS) and Young"s Modulus (YM), but decreased the elongation at break (EAB), oxygen permeability, and water vapor permeability of the CS films.	Water	177-182	neutrophil cytosolic factor 4	Homo sapiens	16-19
34034109-8	2021	Under the selected conditions, the method had a good linear response for the analytes in the range of 0.06-120 ng mL-1 for water and 1.5-1200 ng g-1 for honey samples.	Water	123-128	L1 cell adhesion molecule	Mus musculus	114-118
10722845-4	2000	hIAPP, solubilised in HFIP, filtered and lyophilised remained in stable random structure for up to 7 days in water; in PB, insoluble aggregates precipitated from which protofilaments and fibrils formed with time.	Water	109-114	islet amyloid polypeptide	Homo sapiens	0-5
10713206-0	2000	Influence of water activity and aqueous solvent ordering on enzyme kinetics of alcohol dehydrogenase, lysozyme, and beta-galactosidase.	Water	13-18	galactosidase beta 1	Homo sapiens	116-134
34034109-9	2021	The limits of detections (S/N=3) fell in the range of 0.02-0.06 ng mL-1 for water and 0.5-1.5 ng g-1 for honey samples.	Water	76-81	L1 cell adhesion molecule	Mus musculus	67-71
10713206-1	2000	Effects of the water activity (a(w)) and the solvent ordering, as determined by the activity coefficient of water, were investigated on the enzyme kinetics of alcohol dehydrogenase, lysozyme, and beta-galactosidase in various aqueous solutions.	Water	15-20	galactosidase beta 1	Homo sapiens	196-214
10713206-1	2000	Effects of the water activity (a(w)) and the solvent ordering, as determined by the activity coefficient of water, were investigated on the enzyme kinetics of alcohol dehydrogenase, lysozyme, and beta-galactosidase in various aqueous solutions.	Water	108-113	galactosidase beta 1	Homo sapiens	196-214
10795927-6	2000	Deletion of AQP1 or AQP5, water channels in lung endothelia and epithelia, resulted in a 90% decrease in airspace-capillary water permeability.	Water	26-31	aquaporin 1	Mus musculus	12-16
33956919-6	2021	The as-produced QDs show intrinsic characteristics and outstanding water solubility (up to 5 mg mL-1), facilitating their practical applications.	Water	67-72	L1 cell adhesion molecule	Mus musculus	96-100
10724035-10	2000	In water-deprived null mice receiving 5 x 10(9) PFU of AQP1-Ad5, Uosm increased by up to 510 mOsm (mean increase, 225 +/- 24 mOsm; n = 33 mice).	Water	3-8	aquaporin 1	Mus musculus	55-59
33952296-0	2021	Seasonal rhythms of vasopressin release and aquaporin-2 excretion assure appropriate water conservation in humans.	Water	85-90	aquaporin 2	Homo sapiens	44-55
10703660-15	2000	CONCLUSIONS: Oral irrigation with water for 14 days had an improved therapeutic benefit for AP over that of routine oral hygiene alone and this improvement was accompanied by a down-modulation of the pro-inflammatory cytokine profile in GCF.	Water	34-39	GC-rich sequence DNA-binding factor 2	Homo sapiens	237-240
33843193-10	2021	This study demonstrated that Se(IV) acted as an oxidant to activate nZVI, thus improving the reactivity of nZVI toward Se(VI), which displays a potential application of nZVI in the remediation of Se(IV)- and Se(VI)-containing water.	Water	226-231	squalene epoxidase	Homo sapiens	119-125
11469338-1	2000	Polymerizable analog of beta-galactosyl ceramide (beta-GalCer) was synthesized and converted to water-soluble polymers of beta-GalCer (poly-beta-GalCer) having specific affinity with recombinant gp120 of human immunodeficiency virus (HIV)-1 or V3 loop derived synthetic peptide.	Water	96-101	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	195-200
33903256-0	2021	Warm early Mars surface enabled by high-altitude water ice clouds.	Water	49-54	methionyl-tRNA synthetase 1	Homo sapiens	11-15
33903256-1	2021	Despite receiving just 30% of the Earth"s present-day insolation, Mars had water lakes and rivers early in the planet"s history, due to an unknown warming mechanism.	Water	75-80	methionyl-tRNA synthetase 1	Homo sapiens	66-70
33903256-4	2021	Here, we use a global climate model (GCM) to show that a cloud greenhouse can warm a Mars-like planet to global average annual-mean temperature ([Formula: see text]) ~265 K, which is warm enough for low-latitude lakes, and stay warm for centuries or longer, but only if the planet has spatially patchy surface water sources.	Water	310-315	methionyl-tRNA synthetase 1	Homo sapiens	85-89
18238674-7	2000	The ice water-quenched 15% HFP copolymer exhibited the lowest strain response among the three polymeric materials tested, /spl ap/3%, with a dielectric constant of 12.2.	Water	8-13	sphingosine-1-phosphate lyase 1	Homo sapiens	123-126
34056401-0	2021	Effect of Water on the Chain Reaction Characteristics of Gas Explosion.	Water	10-15	gastrin	Homo sapiens	57-60
34056401-2	2021	The gas explosion response under four different water contents was tested and simulated.	Water	48-53	gastrin	Homo sapiens	4-7
34056401-3	2021	The effects of water on the pressure, free radicals, and reactants of gas explosion were compared and analyzed.	Water	15-20	gastrin	Homo sapiens	70-73
10642600-4	2000	Osmotic water permeability (P(f)) in response to a 200 mM NaCl gradient (bath &gt; lumen) was reduced about 2-fold in AQP1(+/-) mice and by more than 50-fold in AQP1(-/-) mice.	Water	8-13	aquaporin 1	Mus musculus	118-122
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	49-54	gastrin	Homo sapiens	58-61
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	49-54	gastrin	Homo sapiens	185-188
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	49-54	gastrin	Homo sapiens	185-188
10642600-4	2000	Osmotic water permeability (P(f)) in response to a 200 mM NaCl gradient (bath &gt; lumen) was reduced about 2-fold in AQP1(+/-) mice and by more than 50-fold in AQP1(-/-) mice.	Water	8-13	aquaporin 1	Mus musculus	161-165
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	49-54	gastrin	Homo sapiens	185-188
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	106-111	gastrin	Homo sapiens	58-61
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	106-111	gastrin	Homo sapiens	185-188
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	106-111	gastrin	Homo sapiens	185-188
34048270-9	2021	The alterations observed in apical membranes AQP2 expression could explain, at least in part, the evolution time of water kidney management in the postobstructive phase of BUO.	Water	116-121	aquaporin 2	Rattus norvegicus	45-49
33983707-8	2021	The OER performance of exfoliated CoPS3 reported herein yields competitive values compared to those reported for other Co-based and MPX3 in the literature, thus holding substantial promise for use as an efficient material for the anodic water-splitting reaction.	Water	237-242	COP9 signalosome subunit 3	Homo sapiens	34-39
10642600-6	2000	This information, together with p-chloromercuribenzenesulfonate inhibition measurements, suggests that nearly all NaCl-driven water transport occurs by a transcellular route through AQP1, whereas raffinose-driven water transport also involves a parallel, AQP1-independent, mercurial-insensitive pathway.	Water	126-131	aquaporin 1	Mus musculus	182-186
10642600-7	2000	Interestingly, urea was also able to drive water movement across the AQP1-independent pathway.	Water	43-48	aquaporin 1	Mus musculus	69-73
33988364-8	2021	The composite membranes reported in this work as eco-friendly separation materials possessed all these characters in oil/water separation.	Water	121-126	ciliogenesis associated kinase 1	Homo sapiens	49-52
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	106-111	gastrin	Homo sapiens	185-188
11070420-7	2000	CONCLUSIONS: Elevated Na(+) (and possibly Cl(-)) in combination with high NO(-)(3) concentrations in drinking water leads to an increase of SBP and MAP in fourth and fifth graders.	Water	110-115	selenium binding protein 1	Homo sapiens	140-143
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	106-111	gastrin	Homo sapiens	58-61
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	106-111	gastrin	Homo sapiens	185-188
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	106-111	gastrin	Homo sapiens	185-188
34056401-4	2021	The research results show that the inhibition of water on gas explosion was enhanced with the increase of water fraction in the initial mixture; the temperature, pressure, catastrophic gases such as CO, and concentration of activation centers in the reaction system can be reduced by water; the intensity of gas explosion can be reduced by inhibiting the formation of H, O, and OH free radicals, the main reactants of gas explosion and gas explosion energy.	Water	106-111	gastrin	Homo sapiens	185-188
33998793-4	2021	Here we report a pH increase during fibril formation of alpha-synuclein, observed using three complementary experimental methods: pH electrode measurements in water; colorimetric changes of a fluorescent indicator; and chemical shift changes for histidine residues using solution state NMR spectroscopy.	Water	159-164	synuclein alpha	Homo sapiens	56-71
34038101-2	2021	The balance of water coordination and the multitude of bonding of the weakly coordinated nitrate lead to a progressive change in the coordination number of the Cd2+ ions from eight to seven to six without great perturbation to the 4-fold interpenetration three-dimensional framework.	Water	15-20	CD2 molecule	Homo sapiens	160-163
10794494-1	2000	Aquaporin-1(AQP1) and AQP2 are members of the aquaporin family of cell membrane water channel transport proteins and have been implicated in the regulation of renal water excretion.	Water	80-85	aquaporin 1	Mus musculus	0-16
33782168-5	2021	Water loading reduced aquaporin-2 but increased Tamm-Horsfall protein (THP) and particle detection by NTA.	Water	0-5	aquaporin 2	Homo sapiens	22-33
34058710-1	2021	Soft interlayers are distiuctive geological units that serve as semi-permeable layers that regulate water flow and chemical transport in the subsurface.	Water	100-105	POC1 centriolar protein A	Homo sapiens	0-4
12110911-7	2000	The results showed that the lowest water content that could induce motion of RNase A by water is about 0.20 g of water per g of RNase A.	Water	35-40	ribonuclease A family member 1, pancreatic	Homo sapiens	77-84
34058710-3	2021	Duo to the low-permeability of Permian Maokou soft interlayers, water contents remain invariable and cause continuous weakening effect to its shear strength.	Water	64-69	POC1 centriolar protein A	Homo sapiens	46-50
34033479-7	2021	Strong correlations between concentrations of gas-phase NCl3 with concentrations of CO2 and water (relative humidity) were found and attributed to similar features in their physical transport processes in pool air.	Water	92-97	gastrin	Homo sapiens	46-49
34033479-8	2021	A vertical gradient in gas-phase NCl3 concentrations was periodically observed above the water surface, demonstrating that swimmers can be exposed to elevated levels of NCl3 beyond those measured in the bulk air.	Water	89-94	gastrin	Homo sapiens	23-26
34037027-0	2021	Interlayer hydrogen bonding directed magnetic properties for a different number of water-intercalated structural heterometallic phosphates based on paddlewheel units Ru2(PO4)46.	Water	83-88	doublecortin domain containing 2	Homo sapiens	166-176
33965691-6	2021	We recently demonstrated that a purified ulvan extract activates chicken heterophils and monocytes in vivo through TLR2 and TLR4 receptors when given in drinking water.	Water	162-167	toll like receptor 4	Gallus gallus	124-128
12110911-7	2000	The results showed that the lowest water content that could induce motion of RNase A by water is about 0.20 g of water per g of RNase A.	Water	35-40	ribonuclease A family member 1, pancreatic	Homo sapiens	128-135
12110911-7	2000	The results showed that the lowest water content that could induce motion of RNase A by water is about 0.20 g of water per g of RNase A.	Water	88-93	ribonuclease A family member 1, pancreatic	Homo sapiens	77-84
34034129-8	2021	These findings revealed that the FCM algorithm"s presence impressively improved the BPNN model"s accomplishment in predicting heavy metal"s sorption efficiency onto biochar, and the proposed FCM-BPNN model can improve water/wastewater treatment plants" quality and provide a more efficient process for heavy metals with performance superiority.	Water	218-223	nucleolar protein 3	Homo sapiens	33-36
34034129-8	2021	These findings revealed that the FCM algorithm"s presence impressively improved the BPNN model"s accomplishment in predicting heavy metal"s sorption efficiency onto biochar, and the proposed FCM-BPNN model can improve water/wastewater treatment plants" quality and provide a more efficient process for heavy metals with performance superiority.	Water	218-223	nucleolar protein 3	Homo sapiens	191-194
12110911-7	2000	The results showed that the lowest water content that could induce motion of RNase A by water is about 0.20 g of water per g of RNase A.	Water	88-93	ribonuclease A family member 1, pancreatic	Homo sapiens	128-135
32245905-1	2021	Water excretion by the kidney is regulated by the neurohypophyseal peptide hormone vasopressin through actions in renal collecting duct cells to regulate the water channel protein, aquaporin-2.	Water	0-5	aquaporin 2	Homo sapiens	181-192
12110911-7	2000	The results showed that the lowest water content that could induce motion of RNase A by water is about 0.20 g of water per g of RNase A.	Water	88-93	ribonuclease A family member 1, pancreatic	Homo sapiens	77-84
12110911-7	2000	The results showed that the lowest water content that could induce motion of RNase A by water is about 0.20 g of water per g of RNase A.	Water	88-93	ribonuclease A family member 1, pancreatic	Homo sapiens	128-135
12110911-8	2000	That means the motion of RNase A molecule becomes detectable when there are 152 water molecules around one RNase A molecule.	Water	80-85	ribonuclease A family member 1, pancreatic	Homo sapiens	25-32
33894969-1	2021	Cadmium (Cd2+) is a toxic metal ion widely existing in water, soil and food.	Water	55-60	CD2 molecule	Homo sapiens	9-12
12110911-8	2000	That means the motion of RNase A molecule becomes detectable when there are 152 water molecules around one RNase A molecule.	Water	80-85	ribonuclease A family member 1, pancreatic	Homo sapiens	107-114
33894969-9	2021	The proposed device exhibits a limit of detection of 11.3 nM of Cd2+, selectivity >200-fold against other metal ions, high tolerance to the interferents present in drinking water and high recovery rate in tap water.	Water	173-178	CD2 molecule	Homo sapiens	64-67
33894969-9	2021	The proposed device exhibits a limit of detection of 11.3 nM of Cd2+, selectivity >200-fold against other metal ions, high tolerance to the interferents present in drinking water and high recovery rate in tap water.	Water	209-214	CD2 molecule	Homo sapiens	64-67
33991463-1	2021	Functional interaction between the selective water channel AQP4 and several ion channels, such as TRPV4, NKCC1, and Na+ /K+ -ATPase, closely participate to regulate osmotic homeostasis.	Water	45-50	aquaporin 4	Rattus norvegicus	59-63
10561612-6	1999	The crystal structural analyses of K1M, K1A and Gly(-1) revealed that the introduction of a residue at the N-terminal of human lysozyme caused the destruction of hydrogen bond networks with ordered water molecules, resulting in the destabilization of the protein.	Water	198-203	threonine aldolase 1, pseudogene	Homo sapiens	35-54
33991463-1	2021	Functional interaction between the selective water channel AQP4 and several ion channels, such as TRPV4, NKCC1, and Na+ /K+ -ATPase, closely participate to regulate osmotic homeostasis.	Water	45-50	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	98-103
33991463-10	2021	Moreover, the transport of water and ions by AQP4 may be changed during immobilization-induced muscle atrophy.	Water	27-32	aquaporin 4	Rattus norvegicus	45-49
34024141-6	2021	Here, we review recent advances in MRI and commercially available OCT technologies that can measure stimulus-evoked changes in subretinal space water content based on changes in the external limiting membrane-retinal pigment epithelium region.	Water	144-149	plexin A2	Homo sapiens	66-69
10570038-3	1999	Using the substituted-cysteine accessibility method, we have identified the residues that form the surface of the water-accessible binding-site crevice in the dopamine D2 receptor.	Water	114-119	dopamine receptor D2	Homo sapiens	159-179
34051467-0	2021	Nanowire-structured FeP-CoP arrays as highly active and stable bifunctional electrocatalyst synergistically promoting high-current overall water splitting.	Water	139-144	caspase recruitment domain family member 16	Homo sapiens	24-27
33675833-4	2021	The copolymers exhibit self-organization capability in water, with critical association concentration of 42 and 50 mug mL-1.	Water	55-60	L1 cell adhesion molecule	Mus musculus	119-123
33372732-9	2021	However, the mRNA and protein levels of MyBPH (which is responsible for meat quality, e.g. water content, colour and tenderness) are significantly higher in both 1-day-old piglets and adult JNPs than in Berkshire pigs.	Water	91-96	myosin binding protein H	Sus scrofa	40-45
10561533-0	1999	Crystal structure at 1.63 A resolution of the native form of porcine beta-trypsin: revealing an acetate ion binding site and functional water network.	Water	136-141	serine protease 1	Homo sapiens	69-81
33876814-1	2021	Gas hydrates (clathrate hydrates, clathrates, or hydrates) are crystalline inclusion compounds composed of water and gas molecules.	Water	107-112	gastrin	Homo sapiens	0-3
33988991-8	2021	Our observations also suggest that the displacement of ordered water in the binding pocket of D3R contributes to the affinity of the compounds containing an allosteric binding motif.	Water	63-68	dopamine receptor D3	Homo sapiens	94-97
10561533-3	1999	The new high resolution native porcine beta-trypsin (BPT) structure is aimed at extending the knowledge on the conformation of the active site and the ordered water structure within and around the active site.	Water	159-164	serine protease 1	Homo sapiens	39-51
10555085-8	1999	When implanted subcutaneously into the mouse back, bFGF-incorporating acidic and basic gelatin hydrogels with higher water contents were degraded with time faster than those with lower water contents.	Water	117-122	fibroblast growth factor 2	Mus musculus	51-55
33983544-4	2021	The taurine-modified graphene oxide carrier (Tau-GO) was synthesized by chemical method to obtain Tau-GO that has a good dispersibility and stability in water, with a zeta potential of - 38.8 mV and a particle size of 242 nm.	Water	153-158	microtubule associated protein tau	Homo sapiens	45-48
33983544-4	2021	The taurine-modified graphene oxide carrier (Tau-GO) was synthesized by chemical method to obtain Tau-GO that has a good dispersibility and stability in water, with a zeta potential of - 38.8 mV and a particle size of 242 nm.	Water	153-158	microtubule associated protein tau	Homo sapiens	98-101
33544559-10	2021	Leptin showed a significant direct correlation with nutritional BMI (r = 0.72, P <0.001), fat tissue index (r = 0.74, P <0.001) and statistically significant inverse correlation with leantissue index (r = -0.349, P <0.05) and inverse correlation with volemic parameters (overhydration / extracellular water ratio (r = -0.38, P <0.001), but no association with anemia and mineral bone parameters was observed.	Water	301-306	leptin	Homo sapiens	0-6
34044194-6	2021	The satisfactory results from the proposed method of ClO- detection in tap water and drinking water samples, suggesting promising application of GAAP-CDs for ClO- detection.	Water	75-80	transmembrane BAX inhibitor motif containing 4	Homo sapiens	145-149
34044194-6	2021	The satisfactory results from the proposed method of ClO- detection in tap water and drinking water samples, suggesting promising application of GAAP-CDs for ClO- detection.	Water	94-99	transmembrane BAX inhibitor motif containing 4	Homo sapiens	145-149
33851836-1	2021	Bisulfite (HSO3-) is usually widely added to tap water and food because it has antibacterial, bleaching, and antioxidant effects.	Water	49-54	transporter associated with antigen processing, subunit type c	Danio rerio	45-48
33851836-4	2021	In this work, a new reaction-based ratiometric fluorescent probe KQ-SO2 was rationally designed, which could be used for the highly selective detection of HSO3- in tap water, real food samples, onion tissues, and zebrafish.	Water	168-173	transporter associated with antigen processing, subunit type c	Danio rerio	164-167
33851836-6	2021	In addition, KQ-SO2 has been successfully applied for the detection of HSO3- in tap water, real food samples, onion tissues, and zebrafish with satisfactory results.	Water	84-89	transporter associated with antigen processing, subunit type c	Danio rerio	80-83
33885226-3	2021	Ni-MOF [Ni2(H4L)(H2O)9(C2H7SO)(C2H7NCO)] displayed monoclinic crystal structure with space group of P 21/c, a=11.887 A, b=34.148 A, c=11.131 A, alpha=gamma=90o, beta=103.374o, where a nickel-hexahydrate moiety located inside the void space of the framework through several H-bonding interactions.	Water	17-20	H4 clustered histone 7	Homo sapiens	12-15
10555085-8	1999	When implanted subcutaneously into the mouse back, bFGF-incorporating acidic and basic gelatin hydrogels with higher water contents were degraded with time faster than those with lower water contents.	Water	185-190	fibroblast growth factor 2	Mus musculus	51-55
10555085-12	1999	These findings indicate that the controlled release of biologically active bFGF is caused by biodegradation of the acidic gelatin hydrogel, resulting in induction of vascularization effect dependent on the water content.	Water	206-211	fibroblast growth factor 2	Mus musculus	75-79
33660401-4	2021	AKAPs such as AKAP18, AKAP220, AKAP-Lbc and STUB1, and PDE4 coordinate arginine-vasopressin (AVP)-induced water reabsorption by collecting duct principal cells.	Water	106-111	A-kinase anchoring protein 11	Homo sapiens	22-29
10537135-5	1999	Intracerebroventricular injection of the angiotensin AT1 antagonist losartan (10 microg) reduced water drinking induced by iv infusion of relaxin.	Water	97-102	angiotensin II receptor, type 1a	Rattus norvegicus	53-56
33719573-6	2021	We first used Monte-Carlo simulations to demonstrate that dMRI is sensitive to restricted tissue water diffusion at the scale of the kidney tubule.	Water	97-102	mrityu	Drosophila melanogaster	58-62
33421787-2	2021	Super-scale climatic anomalies resulted in strong vertical water column stratification that stimulated development of a dynamic P. verruculosa thin layer (up to 38 mug chl a L-1) for several weeks in Reloncavi Sound.	Water	59-64	L1 cell adhesion molecule	Mus musculus	174-177
33719573-8	2021	The biophysical model to fit the dMRI signal was based on a superposition of freely diffusing water and water diffusing inside infinitely long cylinders of different diameters.	Water	94-99	mrityu	Drosophila melanogaster	33-37
10531324-0	1999	Thermodynamic analyses reveal role of water release in epitope recognition by a monoclonal antibody against the human guanylyl cyclase C receptor.	Water	38-43	guanylate cyclase 2C	Homo sapiens	118-136
33719573-8	2021	The biophysical model to fit the dMRI signal was based on a superposition of freely diffusing water and water diffusing inside infinitely long cylinders of different diameters.	Water	104-109	mrityu	Drosophila melanogaster	33-37
33749322-5	2021	Altered water balance coincides with a decrease in AQP2 phosphorylation and apical localization despite increased levels of the vasopressin surrogate marker, copeptin.	Water	8-13	aquaporin 2	Mus musculus	51-55
33872333-5	2021	HLp-nF1 treated rats showed improvements in fecal pellet number, weight, water content, intestinal transit length, and contractility compared to the constipation-induced rats.	Water	73-78	neurofibromin 1	Rattus norvegicus	4-7
33933799-5	2021	The dependence in Br- hydration on the molar ratio of water to HTAB (w) is investigated using X-ray absorption fine structure (XAFS).	Water	54-59	chromosome 12 open reading frame 73	Homo sapiens	18-20
10527837-6	1999	DRPLA protein complex is water-insoluble but soluble in SDS and reducing agent, and displays no difference in water insolubility between control and DRPLA brain tissue.	Water	25-30	atrophin 1	Homo sapiens	0-5
33933799-6	2021	These systems cover a wide range of w values (0-30) and allow us to study the impact of this parameter on the local structure of Br- at the RM interface, which comprises water, surfactant headgroups, and organic solvent components.	Water	170-175	chromosome 12 open reading frame 73	Homo sapiens	129-131
33837552-1	2021	In the present study, a kind of structured lipids, namely 1,3-di-oleic-2-medium chain (OMO) triacylglycerols, were synthesized through lipase-catalyzed reactions using coconut oil and rapeseed acid as materials in a trace water-in-oil system.	Water	222-227	PAN0_003d1715	Moesziomyces antarcticus	135-141
33837552-7	2021	A trace water-in-oil system was a green and efficient alternative for lipase-catalyzed production of OMO, and this study provided crucial insights into the stability/instability and catalytic mechanisms of lipase in the synthesis of structured lipids.	Water	8-13	PAN0_003d1715	Moesziomyces antarcticus	70-76
33837552-7	2021	A trace water-in-oil system was a green and efficient alternative for lipase-catalyzed production of OMO, and this study provided crucial insights into the stability/instability and catalytic mechanisms of lipase in the synthesis of structured lipids.	Water	8-13	PAN0_003d1715	Moesziomyces antarcticus	206-212
33465572-5	2021	Moreover, the probe has good water solubility, which ensures that it has good biocompatibility and can be easily applied to detect beta-galactosidase in living cells and tissues.	Water	29-34	galactosidase, beta 1	Mus musculus	131-149
10493928-1	1999	Oxalate oxidase (EC 1.2.3.4) catalyses the conversion of oxalate and dioxygen into CO(2) and H(2)O(2).	Water	93-98	LOC548260	Hordeum vulgare	0-15
33848364-4	2021	Until recently, the pathophysiology of hereditary xerocytosis was mainly believed to be based on the "PIEZO1-Gardos channel axis" in erythrocytes, according to which PIEZO1-activating mutations induce a calcium influx that secondarily activates the Gardos channel, leading to potassium and water efflux and subsequently to red blood cell dehydration.	Water	290-295	piezo type mechanosensitive ion channel component 1	Homo sapiens	102-108
33848364-4	2021	Until recently, the pathophysiology of hereditary xerocytosis was mainly believed to be based on the "PIEZO1-Gardos channel axis" in erythrocytes, according to which PIEZO1-activating mutations induce a calcium influx that secondarily activates the Gardos channel, leading to potassium and water efflux and subsequently to red blood cell dehydration.	Water	290-295	piezo type mechanosensitive ion channel component 1	Homo sapiens	166-172
33997317-3	2021	Furthermore, our study demonstrated that a highly water-soluble curcuminoids-rich extract (CRE-Ter) inhibits osteoclastogenesis through NFkappaB pathway.	Water	50-55	telomerase RNA component	Mus musculus	95-98
33849366-9	2021	CONCLUSIONS: Water, heat, and excipients" nitrite and nitrate levels are the key players, which should collectively exist, to cause NDMA formation during MET tablets manufacturing.	Water	13-18	SAFB like transcription modulator	Homo sapiens	154-157
10709761-6	1999	Ice bathing and cold exposure did not influence CBG, and water deprivation elevated serum CBG.	Water	57-62	serpin family A member 6	Rattus norvegicus	90-93
33924231-8	2021	Particularly, the knockdown of the water channel aquaporin 3 gene (AQP3) impaired multicellular aggregate formation in 3D culture through the rearrangement of the actomyosin cytoskeleton.	Water	35-40	aquaporin 3 (Gill blood group)	Homo sapiens	67-71
33933794-0	2021	CoP imbedded g-C3N4 heterojunctions for highly efficient photo, electro and photoelectrochemical water splitting.	Water	97-102	caspase recruitment domain family member 16	Homo sapiens	0-3
33933794-3	2021	In photocatalytic water half-splitting for hydrogen evolution reaction, the as-obtained 0.5% CoP-CN achieved a rate at 959.4 mumol h-1 g-1 and 59.1 mumol h-1 g-1 when irradiated by simulated sunlight and visible light respectively, almost 3.1 times and 15.8 times that of pristine g-C3N4, For photocatalytic water full-splitting, a stoichiometric evolution of H2 (14.7 mumol h-1 g-1) and O2 (7.6 mumol h-1 g-1) was observed on 3%Pt-0.5% CoP-CN composite.	Water	18-23	caspase recruitment domain family member 16	Homo sapiens	93-96
33933794-3	2021	In photocatalytic water half-splitting for hydrogen evolution reaction, the as-obtained 0.5% CoP-CN achieved a rate at 959.4 mumol h-1 g-1 and 59.1 mumol h-1 g-1 when irradiated by simulated sunlight and visible light respectively, almost 3.1 times and 15.8 times that of pristine g-C3N4, For photocatalytic water full-splitting, a stoichiometric evolution of H2 (14.7 mumol h-1 g-1) and O2 (7.6 mumol h-1 g-1) was observed on 3%Pt-0.5% CoP-CN composite.	Water	308-313	caspase recruitment domain family member 16	Homo sapiens	93-96
33933794-5	2021	Meanwhile, a higher photocurrent response and larger anodic photocurrent was detected over 0.5% CoP-CN photoanode during the photoelectrochemical water splitting process, relative to pristine g-C3N4 and its analogues.	Water	146-151	caspase recruitment domain family member 16	Homo sapiens	96-99
33838186-9	2021	The acquired findings indicate that HA/MNPs are a novel binder/support system to IDH, and IDH immobilized on this system can become a very important biocatalyst working with high accuracy and sensitivity for the determination of magnesium in drinking water and other biological solutions.	Water	251-256	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	90-93
33933794-7	2021	The contrastive redox roles of CoP in both photocatalytic water half-splitting and full-splitting processes have been fully explored and revealed.	Water	58-63	caspase recruitment domain family member 16	Homo sapiens	31-34
10489294-3	1999	The increase in the interlayer distance from 15.02 to 16.36 A on going from KPP-hyd to KPP-hex was attributed to the replacement of water molecules with the longer hexylamine molecules in the phenylphosphonate P-O-H binding sites of the grafted KPP host.	Water	132-137	hematopoietically expressed homeobox	Homo sapiens	91-94
33933794-8	2021	This design on covalent organic framework of highly efficient CoP-based heterojunctions holds great promise for direct water splitting applications in utilizing solar energy.	Water	119-124	caspase recruitment domain family member 16	Homo sapiens	62-65
33868761-4	2021	Furthermore, the identification standard of virus signals is established by machine-learning and identification techniques, resulting in an especially low detection limit of 80 copies mL-1 for the simulated contaminated water by SARS-CoV-2 virus with complex circumstance as short as 5 min, which is of great significance for achieving real-time monitoring and early warning of coronavirus.	Water	220-225	L1 cell adhesion molecule	Mus musculus	184-188
33493870-9	2021	We found that the Notch signaling pathway was activated and the Th17 frequency was elevated in rats with EAU, leading to disrupted CD4+/CD8+ and Th17/Treg balance.	Water	105-108	notch receptor 1	Rattus norvegicus	18-23
33493870-12	2021	LXD can efficiently inhibit Th17 cell differentiation, decrease inflammatory cytokine expression, and restore the CD4+/CD8+ and Th17/Treg balance by inhibiting the activation of the Notch signaling pathway in rats with EAU, thus effectively alleviating eye inflammation, protecting eye tissue structures, and positively regulating the immune state of the whole body and the intraocular microenvironment.	Water	219-222	notch receptor 1	Rattus norvegicus	182-187
10576350-1	1999	BACKGROUND/AIMS: This study was designed to determine whether epidermal growth factor may have a role in the stomach of portal hypertensive rats after exposure to water immersion and restraint stress.	Water	163-168	epidermal growth factor like 1	Rattus norvegicus	62-85
33166830-5	2021	The human guanosine 5"-diphosphate (GDP)-mannose 4,6-dehydratase was recently shown to use a minimal catalytic machinery, exactly as predicted earlier from theoretical considerations, for the beta-elimination of water from the keto-hexose species.	Water	212-217	GDP-mannose 4,6-dehydratase	Homo sapiens	10-64
33903581-4	2021	The dramatic increase in the number of Lessepsian migrants (an average of 2.5 species per year) is most likely due to the increased water influx between the Red Sea and the Mediterranean, following the recent opening of the new parallel, 72 km, "new canal" and the enlargement of other parts of the Suez Canal.	Water	132-137	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	161-164
10455106-1	1999	The reduction with excess H(2)O(2) of human Mn(III) superoxide dismutase (SOD) and the active-site mutant Y34F Mn(III)SOD was measured by scanning stopped-flow spectrophotometry and revealed the presence of an intermediate in the reduction of the manganese.	Water	26-31	superoxide dismutase 2	Homo sapiens	74-77
33656871-3	2021	Here we present an organic-inorganic molecular hybrid, beta""-(BEDO-TTF)3[Co(pdms)2] (MeCN)(H2O)2 (BO3) (BEDO-TTF = bis(ethylenedioxy)tetrathiafulvalene and H2pdms = 1,2-bis(methanesulfonamido)benzene), which manifests both metallic conduction (electrical conductivity up to 1000 S cm-1 at 12 K under 2.0 gigapascal pressure) and SMM behavior in the temperature range 12-26 K for the first time.	Water	92-95	ras homolog family member H	Homo sapiens	68-71
33917489-0	2021	Long-Term Stability of Different Kinds of Gas Nanobubbles in Deionized and Salt Water.	Water	80-85	gastrin	Homo sapiens	42-45
33398763-0	2021	A Lagrangian analysis of the gravity-inertial oil spreading on the calm sea using the reflective oil-water interface treatment.	Water	101-106	synaptosome associated protein 91	Homo sapiens	67-71
33636332-7	2021	Taken all together, we demonstrate that plasma treated water-derived oxidants sensitize pancreatic cancer cells to ferroptotic cell death by targeting a NRF2-HMOX1-GPX4 specific kinase signaling network.	Water	55-60	heme oxygenase 1	Homo sapiens	158-163
33636332-7	2021	Taken all together, we demonstrate that plasma treated water-derived oxidants sensitize pancreatic cancer cells to ferroptotic cell death by targeting a NRF2-HMOX1-GPX4 specific kinase signaling network.	Water	55-60	glutathione peroxidase 4	Gallus gallus	164-168
10397883-2	1999	A biphasic thermodynamic model is proposed which includes a nonuniform distribution of reagents across the cell membrane, a transmembrane pH gradient, ideal and nonideal solution models, and a basic reaction stoichiometry (ACP + (1/2) EtOH + (1/2)H2O &lt;--&gt; PEA + (1/2)Ac- + (1/2)H+).	Water	247-250	acyl carrier protein	Saccharomyces cerevisiae S288C	223-233
33862576-10	2021	These void spaces are filled with diffused water molecules, leading to swelling of the MEP hydrogel.	Water	43-48	neurolysin	Homo sapiens	87-90
10415112-2	1999	The ch-DHFR entrapped in CTAB and DAB reverse micelles shows very low activity at a lower ratio of water to surfactant (omega(0)).	Water	99-104	dihydrofolate reductase	Cricetulus griseus	7-11
33453412-7	2021	Our work identifies a functional allosteric pathway connected by specific hydration sites in beta2AR that has not been reported before and provides insight into water-mediated networks in GPCRs in general.	Water	161-166	adenosine A2a receptor	Homo sapiens	93-100
33513451-2	2021	This study investigated the batch adsorption performance of a potential cobalt adsorbent, dicalcium phosphate dihydrate (DCPD), in immobilizing Co2+ from water.	Water	154-159	complement C2	Homo sapiens	144-147
33513451-8	2021	Intraparticle diffusion also contributed to the overall removal kinetics of Co2+ from water.	Water	86-91	complement C2	Homo sapiens	76-79
10415112-7	1999	Our results suggest that the reduced activity of ch-DHFR in reverse micelles at low omega(0) is due to the restrictions in enzyme conformation caused by an environment with low water content.	Water	177-182	dihydrofolate reductase	Cricetulus griseus	52-56
33732385-2	2021	A number of recent studies have revealed that the water channel protein aquaporin-5 (AQP5) has become a major player in multiple types of cancer.	Water	50-55	aquaporin 5	Homo sapiens	72-83
11715416-7	1999	mPAP in hypercapnia group was (2.0 +/- 0.4) kPa, PaCO2 (7.4 +/- 0.4) kPa, T1/2 (150 +/- 23) min, LPO (8.8 +/- 2.0) nmol/ml, SOD (682 +/- 341) U/g Hb1 and water content was (78.8 +/- 1.8)% in lung and (76.04 +/- 1.07)% in muscular tissues.	Water	154-159	phospholipid phosphatase 1	Mus musculus	0-4
33732385-2	2021	A number of recent studies have revealed that the water channel protein aquaporin-5 (AQP5) has become a major player in multiple types of cancer.	Water	50-55	aquaporin 5	Homo sapiens	85-89
33867998-5	2021	LV weight was 19% higher in AK1-OE males due to higher tissue water content in the absence of hypertrophy or fibrosis.	Water	62-67	adenylate kinase 1	Mus musculus	28-31
33733600-6	2021	Experimental characterizations and DFT calculations demonstrate that the strong electronic interaction at the heterointerface of CoNiP/CoP is achieved via the electron transfer from CoNiP to the heterointerface, which directly promotes the dissociation of water at heterointerface and desorption of hydrogen on CoNiP.	Water	256-261	caspase recruitment domain family member 16	Homo sapiens	135-138
33789623-7	2021	RESULTS: In relation to the decline of mortality rates due to diarrhea in the municipalities, positive effect modification were observed in the presence of: high coverage of the target population by the PBF and access to water, 0.54 (0.28-1.04) / 0.55 (0.29-1.04); high coverage by the total population by the PBF and access to water, 0.97 (0.95-1.00) and high coverage by the total population by the PBF and access to sanitation, 0.98 (0.97-1.00).	Water	221-226	zinc finger protein 395	Homo sapiens	310-313
33789623-7	2021	RESULTS: In relation to the decline of mortality rates due to diarrhea in the municipalities, positive effect modification were observed in the presence of: high coverage of the target population by the PBF and access to water, 0.54 (0.28-1.04) / 0.55 (0.29-1.04); high coverage by the total population by the PBF and access to water, 0.97 (0.95-1.00) and high coverage by the total population by the PBF and access to sanitation, 0.98 (0.97-1.00).	Water	221-226	zinc finger protein 395	Homo sapiens	310-313
33789623-7	2021	RESULTS: In relation to the decline of mortality rates due to diarrhea in the municipalities, positive effect modification were observed in the presence of: high coverage of the target population by the PBF and access to water, 0.54 (0.28-1.04) / 0.55 (0.29-1.04); high coverage by the total population by the PBF and access to water, 0.97 (0.95-1.00) and high coverage by the total population by the PBF and access to sanitation, 0.98 (0.97-1.00).	Water	328-333	zinc finger protein 395	Homo sapiens	203-206
10400657-9	1999	HDL binding to SR-BI allows access of CE molecules to a "channel" formed by the receptor from which water is excluded and along which HDL-CE molecules move down their concentration gradient into the cell plasma membrane.	Water	100-105	scavenger receptor class B, member 1	Mus musculus	15-20
33724853-6	2021	An oxygen-quenchable triplet state (T1) of AI3 was produced upon 416 nm excitation in both water and n-octanol.	Water	91-96	family with sequence similarity 83 member H	Homo sapiens	43-46
33650605-0	2021	Self-assembly of colloidal nanoparticles into 2D arrays at water-oil interfaces: rational construction of stable SERS substrates with accessible enhancing surfaces and tailored plasmonic response.	Water	59-64	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	113-117
33869139-1	2021	The dependence of the volume number density of ion-stabilized gas nanobubbles (bubstons) on the type of gas and the pressure created by this gas in deionized water and saline solution has been investigated.	Water	158-163	gastrin	Homo sapiens	62-65
33724853-2	2021	The compounds were functionalized with water-soluble 2,2"(ethylenedioxy) diethylamine groups, yielding a monomer (AI3) and a dimer (AI4).	Water	39-44	family with sequence similarity 83 member H	Homo sapiens	114-117
10329775-4	1999	The two end base pairs of duplex 1 have a similar NH.O hydrogen-bond pattern involving GGC segments of duplex 2 and a symmetry-related neighbour, while the end base pairs of duplex 2 interact with the GCC and GGG segments of its symmetry-related neighbours through NH.O and NH.N hydrogen bonds and a water-mediated hydrogen bond between the carboxyl groups of C40 and C8.	Water	300-305	guanylate cyclase 2C	Homo sapiens	201-204
33367492-3	2021	Under the optimized SPE conditions, the response linearity for the analysis of the SPE extract of the chlorophenols by high performance liquid chromatography-diode array detector was observed in the range of 0.2-40.0 ng mL-1 for water samples and 5.0-400.0 ng g-1 for honey samples.	Water	229-234	L1 cell adhesion molecule	Mus musculus	220-224
33367492-4	2021	The method detection limits of the analytes were 0.06-0.08 ng mL-1 for water samples and 1.5-2.0 ng g-1 for honey samples.	Water	71-76	L1 cell adhesion molecule	Mus musculus	62-66
33720038-3	2021	On the other hand, in the case of CASP target 624, when its hydration shell is filled, a significant energy gap is observed between the crystal structure and the best conformers proposed during the prediction experiment, strongly suggesting that including explicit water molecules may help identifying unlikely conformers among good-looking ones.	Water	265-270	cartilage associated protein	Homo sapiens	34-38
33790691-4	2021	In the current study, we provided direct evidence that IL-22 treatment decreased infarct size, neurological deficits, and brain water content in mice subjected to cerebral I/R injury.	Water	128-133	interleukin 22	Mus musculus	55-60
10378499-11	1999	The P-300 latencies, after cold water application, decreased by 4.8% (p &lt; .001), from 266.5+/-21.1msec (mean+/-SD) to 253.7+/-16.9msec.	Water	32-37	E1A binding protein p300	Homo sapiens	4-9
33616148-3	2021	The Nd-DTPA was simply generated by heating the mixture of Nd2O3 and DTPA in water at 85  C for 2 h. This dual-modal imaging agent has the advantages of a simple and green synthesis route, no need of purification process, high yield (86.24%), large-scale production capability (>10 g in lab synthesis), good chemical stability and excellent water solubility ( 2 g mL-1).	Water	77-82	L1 cell adhesion molecule	Mus musculus	364-368
33682951-7	2021	A good linear range was observed in the range of 1.0-500.0 ng mL-1 for water and 5.0-500.0 ng mL-1 for urine and plasma.	Water	71-76	L1 cell adhesion molecule	Mus musculus	62-66
33738516-9	2021	IRI, FU, MET, DOX and SUN were efficiently removed by hydrolysis in clean water and present thus lower occupational risk.	Water	74-79	SAFB like transcription modulator	Homo sapiens	9-12
33683865-3	2021	Incorporating all three effects simultaneously into the catalyst structure results in a Co complex [Co(PDI-PyCH3+I-)] with dramatically enhanced activity for CO2 reduction, operating with over an order of magnitude higher activity (TOFcat = 4.1 x 104 s-1) and ~0.2 V more positive catalytic onset (Eonset = -1.52 V vs Fc+/0) compared to the parent complex, an intrinsic activity parameter TOF0 = 6.3 x 10-3 s-1, and >95% Faradaic efficiency for CO production in acetonitrile with 11 M water.	Water	485-490	peptidyl arginine deiminase 1	Homo sapiens	103-106
10378499-14	1999	CONCLUSION: Cold water applied locally to the face and neck region can provoke significant changes in electroencephalographic markers as measured by an electroencephalographic marker (VEP and P-300 latency) and, by inference, may help to improve cognitive function in the elderly.	Water	17-22	E1A binding protein p300	Homo sapiens	192-197
33836608-6	2021	Water-dominated electrostatic field fluctuations bring *Re and CS1 states to a crossing where *Re(CO)3(dmp)+ W1 ET occurs, and CS1 becomes the lowest triplet state.	Water	0-5	myozenin 2	Homo sapiens	63-66
10399677-5	1999	The imidazole compound increased ANGII-induced water intake suggesting its AT1 receptor agonistic properties.	Water	47-52	angiotensin II receptor, type 1a	Rattus norvegicus	75-78
33836608-6	2021	Water-dominated electrostatic field fluctuations bring *Re and CS1 states to a crossing where *Re(CO)3(dmp)+ W1 ET occurs, and CS1 becomes the lowest triplet state.	Water	0-5	myozenin 2	Homo sapiens	127-130
33682127-6	2021	The gels containing 15/20 mM Lys/Arg exhibited a significant increase in the proportion of immobilized water (P21 ).	Water	103-108	H3 histone pseudogene 16	Homo sapiens	110-113
10399677-6	1999	PD 123319 inhibited ANGII-induced water intake at a higher dose (64 nmol), allowing to assume AT1 receptor agonistic properties.	Water	34-39	angiotensin II receptor, type 1a	Rattus norvegicus	94-97
33748293-9	2021	During this time frame, AQP4 level peaked at 12 and 72 h, and these peaks were closely correlated with high brain water content.	Water	114-119	aquaporin 4	Rattus norvegicus	24-28
10320046-1	1999	Newly developed antiviral compounds consisting of an adamantane derivative chemically linked to a water-soluble polyanionic matrix were shown to inhibit HIV-1 infection in lymphoblastoid cells, HeLa CD4+ beta-galactosidase (MAGI) cells and macrophages.	Water	98-103	galactosidase beta 1	Homo sapiens	204-222
33595315-5	2021	Thus, one precondition for gas aggregation on a surface is that the free energy minima of gas induced by the surface be much lower than that induced by water.	Water	152-157	gastrin	Homo sapiens	27-30
10358220-2	1999	When gelatin hydrogels incorporating 125I-labeled bFGF were implanted into the back subcutis of mice, the bFGF radioactivity remaining decreased with time and the retention period was prolonged with a decrease in the water content of the hydrogels.	Water	217-222	fibroblast growth factor 2	Mus musculus	50-54
33206556-4	2021	Passive immunoneutralization of Gpr160 in the 4V blocked the actions of CARTp to inhibit food and water intakes.	Water	98-103	G protein-coupled receptor 160	Rattus norvegicus	32-38
33206556-5	2021	Blockade of Gpr160 in the 4V, independent of pharmacologic CART treatment, caused an increase in both overnight food and water intakes.	Water	121-126	G protein-coupled receptor 160	Rattus norvegicus	12-18
33485266-0	2021	A noise adaptive approach for nodal water demand estimation in water distribution systems.	Water	36-41	nodal growth differentiation factor	Homo sapiens	30-35
33485266-0	2021	A noise adaptive approach for nodal water demand estimation in water distribution systems.	Water	63-68	nodal growth differentiation factor	Homo sapiens	30-35
33485266-2	2021	In using the models for estimating nodal water demands, measurement uncertainty must be considered.	Water	41-46	nodal growth differentiation factor	Homo sapiens	35-40
33485266-6	2021	In this study, we develop a variational Bayesian approach for real-time estimation of noise covariance and nodal water demands.	Water	113-118	nodal growth differentiation factor	Homo sapiens	107-112
10037716-0	1999	The accessibility of iron at the active site of recombinant human phenylalanine hydroxylase to water as studied by 1H NMR paramagnetic relaxation.	Water	95-100	phenylalanine hydroxylase	Homo sapiens	66-91
33717640-2	2021	Here we report a previously unobserved octahedral TSA complex, MgF3(H2O)-, in a 1.5 A resolution Zika virus NS3 helicase crystal structure.	Water	68-71	signal transducer and activator of transcription 5A	Homo sapiens	63-66
33717640-5	2021	DFT analysis further validated the MgF3(H2O)- species, indicating the significance of this TSA for studies of biological motors.	Water	40-43	signal transducer and activator of transcription 5A	Homo sapiens	35-38
33015946-5	2021	Water physisorption experiments reveal the hydrophilic nature of Co-CAT-1 with a total water uptake at room temperature of 470 cm3 g-1.	Water	0-5	GIT ArfGAP 1	Homo sapiens	68-73
33015946-5	2021	Water physisorption experiments reveal the hydrophilic nature of Co-CAT-1 with a total water uptake at room temperature of 470 cm3 g-1.	Water	87-92	GIT ArfGAP 1	Homo sapiens	68-73
10037716-2	1999	The high-spin (S = 5/2) Fe(III) ion at the active site of recombinant human phenylalanine hydroxylase (PAH) has a paramagnetic effect on the longitudinal relaxation rate of water protons.	Water	173-178	phenylalanine hydroxylase	Homo sapiens	76-101
10037716-2	1999	The high-spin (S = 5/2) Fe(III) ion at the active site of recombinant human phenylalanine hydroxylase (PAH) has a paramagnetic effect on the longitudinal relaxation rate of water protons.	Water	173-178	phenylalanine hydroxylase	Homo sapiens	103-106
33221138-1	2021	In this study, we proposed a novel method for the determination of nanomolar dissolved sulfides, including H2S, HS-, and S2- (defined as S(-II)) in water by coupling the classical methylene blue (MB) method with surface-enhanced Raman spectroscopy (SERS) detection.	Water	148-153	transcription elongation factor A1	Homo sapiens	137-143
10037716-7	1999	Thus, the recombinant human PAH appears to have a more solvent-accessible catalytic iron than the rat enzyme, in which the water coordinated to the metal is slowly exchanging with the solvent.	Water	123-128	phenylalanine hydroxylase	Homo sapiens	28-31
33307414-1	2021	We report the photoelectrochemical application of a visible light active FTO-Cu2O/Ag3PO4 photoanode for the abatement of sulfamethoxazole in water.	Water	141-146	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	73-76
10082801-1	1999	Myelin basic protein is a water soluble membrane protein which interacts with acidic lipids through some type of hydrophobic interaction in addition to electrostatic interactions.	Water	26-31	myelin basic protein	Homo sapiens	0-20
33744681-2	2021	Because of its high redox potential and ability to reduce oxygen directly to water, human ceruloplasmin, HCp, the only blue multicopper oxidase present in human plasma, appears to be the ultimate biocatalyst for oxygen biosensors and also biocathodes in biological power sources.	Water	77-82	ceruloplasmin	Homo sapiens	90-103
33646119-2	2021	A SIK3-regulated gene expression program controls the glial capacity to buffer K+ and water in Drosophila, however upstream regulatory mechanisms are unknown.	Water	86-91	Salt-inducible kinase 3	Drosophila melanogaster	2-6
10221645-6	1999	Levels of CD14 in sera from M14S mice after zinc administration were significantly higher than these animals maintained with normal water, M14M mice after zinc administration and non-transgenic mice.	Water	132-137	CD14 antigen	Mus musculus	10-14
33175575-8	2021	AQP5 overexpression in cancers may thus contribute to carcinogenesis and cancer spread by two independent mechanisms: reduced cell-cell adhesion, a characteristic of epithelial-mesenchymal transition, and increased cell migration capacity via water transport.	Water	243-248	aquaporin 5	Homo sapiens	0-4
33559717-3	2021	In this study, we used a novel biomaterial based on calcium-crosslinked alginate-encapsulated bacteria to precipitate Cd2+ in polluted water.	Water	135-140	CD2 molecule	Homo sapiens	118-121
33309746-6	2021	IL-1beta administration reversed the effect of escin on Garcia test scores, the brain water contents, and the Evans blue extravasation.	Water	86-91	interleukin 1 alpha	Mus musculus	0-8
33559717-4	2021	Our results show that calcium-crosslinked alginate-encapsulated bacteria effectively removed Cd2+ ions from cadmium-polluted water.	Water	125-130	CD2 molecule	Homo sapiens	93-96
10552375-2	1999	The RVA pasting parameters of peak viscosity determined in water (PV1) and that determined in 0.05 mM AgNO(3) (used as an amylase inhibitor) (PV2) were successfully used to estimate alpha-amylase activity.	Water	59-64	plasmalemma vesicle associated protein	Homo sapiens	66-69
33559717-5	2021	Approximately 100% of Cd2+ ions were removed by 10 g (wet weight) of this biomaterial when the loading concentration of Cd2+ reached 1 mM in a volume of 50 ml water.	Water	159-164	CD2 molecule	Homo sapiens	22-25
33559717-5	2021	Approximately 100% of Cd2+ ions were removed by 10 g (wet weight) of this biomaterial when the loading concentration of Cd2+ reached 1 mM in a volume of 50 ml water.	Water	159-164	CD2 molecule	Homo sapiens	120-123
33559717-10	2021	Our results indicated that calcium-crosslinked alginate-encapsulated bacteria are suitable for depletion of Cd2+ in polluted water and for production of CdS nanoparticles.	Water	125-130	CD2 molecule	Homo sapiens	108-111
33559717-11	2021	These calcium-crosslinked alginate-encapsulated bacteria are safe for biological manipulation and can be widely used to produce CdS nanoparticles during bioremediation of Cd2+-polluted water.	Water	185-190	CD2 molecule	Homo sapiens	171-174
33559717-12	2021	KEY POINTS:   Calcium-crosslinked alginate-encapsulated bacteria can effectively precipitate Cd2+ in water coupled with production of CdS quantum dots.	Water	101-106	CD2 molecule	Homo sapiens	93-96
33400793-5	2021	In this study we exposed such a model to tritiated water (HTO) for 24 h, with a range of activity levels (up to ~33 kBq mul-1 cm-2).	Water	51-56	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	120-125
10067735-1	1999	BACKGROUND: Growth hormone (GH) stimulates intestinal growth and differentiation and promotes water and ion absorption in the rat intestine.	Water	94-99	gonadotropin releasing hormone receptor	Rattus norvegicus	12-26
33379099-0	2021	A simple and efficient Solid-Phase Microextraction - Gas Chromatography - Mass Spectrometry method for the determination of fragrance materials at ultra-trace levels in water samples using multi-walled carbon nanotubes as innovative coating.	Water	169-174	gastrin	Homo sapiens	53-56
32959071-6	2021	Finally, we found that MMP3 deficient mice show faster spatial learning in Morris water maze and enhanced contextual fear conditioning.	Water	82-87	matrix metallopeptidase 3	Mus musculus	23-27
10067735-1	1999	BACKGROUND: Growth hormone (GH) stimulates intestinal growth and differentiation and promotes water and ion absorption in the rat intestine.	Water	94-99	gonadotropin releasing hormone receptor	Rattus norvegicus	28-30
10188997-15	1999	In conclusion, renal AT2 receptors oppose the sodium and water excretion induced by acute increases in blood pressure and this action cannot be directly explained by changes in cyclic GMP.	Water	57-62	angiotensin II receptor, type 2	Rattus norvegicus	21-24
33279692-4	2021	Experimental results indicate that the higher photocatalytic hydrogen evolution performance can be mainly attributed to the binary Ru-CoP-x co-catalyst with efficient charge separation and promoted surface water reduction kinetics, and the 2D/2D self-assembly structure with strong interface Schottky effect and short charge transport distance.	Water	206-211	caspase recruitment domain family member 16	Homo sapiens	134-137
33639763-6	2021	While CO3  -(H2O)1,2 and CO4  -(H2O) dissociate via loss of water, CO2 loss is the dominant dissociation channel for CO4  -(H2O)2.	Water	32-35	complement C4A (Rodgers blood group)	Homo sapiens	25-28
33639763-6	2021	While CO3  -(H2O)1,2 and CO4  -(H2O) dissociate via loss of water, CO2 loss is the dominant dissociation channel for CO4  -(H2O)2.	Water	60-65	complement C4A (Rodgers blood group)	Homo sapiens	25-28
33639763-6	2021	While CO3  -(H2O)1,2 and CO4  -(H2O) dissociate via loss of water, CO2 loss is the dominant dissociation channel for CO4  -(H2O)2.	Water	32-35	complement C4A (Rodgers blood group)	Homo sapiens	25-28
33639763-0	2021	Infrared spectroscopy of CO3  -(H2O)1,2 and CO4  -(H2O)1,2.	Water	51-54	complement C4A (Rodgers blood group)	Homo sapiens	44-47
33639763-3	2021	The infrared spectra of CO3  -(H2O)1,2 and CO4  -(H2O)1,2 were measured via infrared multiple photon dissociation spectroscopy in both warm and cold environments.	Water	50-53	complement C4A (Rodgers blood group)	Homo sapiens	43-46
10093213-2	1999	Fragment ions corresponding to the elimination of H2O and HN=C=NH are observed in the product ion mass spectra of Lys1-bradykinin and des-Arg1-bradykinin but not in the spectra of bradykinin or des-Arg9-bradykinin.	Water	50-53	arginase 1	Homo sapiens	138-142
33673411-6	2021	The reaction of L3 with PtCl2 in MeCN/H2O gave by serendipity the complex [Pt(L3)(m-1,3-MeCONH)PtCl(MeCN)](BF4)2 H2O, in which two metal centers are bridged by an amidate ligand at a Pt1-Pt2 distance of 2.5798(3) A and feature one square-planar and one octahedral coordination environment.	Water	38-41	zinc finger protein 77	Homo sapiens	183-186
10029036-2	1999	OBJECTIVE: Because of the known sodium and water retention associated with growth hormone (GH) therapy, it is crucial to evaluate the safety of GH after brain injury.	Water	43-48	gonadotropin releasing hormone receptor	Rattus norvegicus	75-89
33635461-9	2021	The maximum fluorescence intensities of C1, C2, C3, and lna(254) were positively related to the trophic state index (TSI), suggesting that humic-like components and lna(254) could be used as indicators to reflect the eutrophication levels of several independent water bodies.	Water	262-267	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	40-50
33369250-0	2021	Hierarchical CoP nanostructures on nickel foam as efficient bifunctional catalysts for water splitting.	Water	87-92	caspase recruitment domain family member 16	Homo sapiens	13-16
33369250-6	2021	The results reported in this paper show that CoP/NF, a layered bifunctional electrocatalyst, is a cost-effective and efficient water splitting electrode.	Water	127-132	caspase recruitment domain family member 16	Homo sapiens	45-48
32927203-3	2021	One additional freezing-thawing cycle at slow freezing rate caused appearance of a 160 kDa myosin-4 fragment in SDS-PAGE, further decreased water-holding of myofibrils and increased surface hydrophobicity.	Water	140-145	myosin heavy chain 4	Homo sapiens	91-99
33600055-4	2021	In this study, we systematically evaluated the effects of protein crystal structural models, scoring functions, heme forms, conserved active site water molecule, and protein flexibility on SOMs prediction of CYP2C9 substrates.	Water	146-151	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	208-214
10029036-2	1999	OBJECTIVE: Because of the known sodium and water retention associated with growth hormone (GH) therapy, it is crucial to evaluate the safety of GH after brain injury.	Water	43-48	gonadotropin releasing hormone receptor	Rattus norvegicus	91-93
33475631-3	2021	In this work, a steric hindrance effect was observed in a quinoline-involved polypyridyl Co complex-based water reduction catalyst (WRC), which impedes the formation of Co(iii)-H from Co(i), two pivotal intermediates for H2 evolution, leading to significantly impaired electrocatalytic and photocatalytic activity with respect to its parent complex, [Co(TPA)Cl]Cl (TPA = tris(2-pyridinylmethyl)-amine).	Water	106-111	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	184-189
10321970-2	1999	Neuronal AT1 receptors within these areas mediate the stimulatory actions of central Ang II on blood pressure, water and sodium intake, and vasopressin secretion, effects that involve the modulation of brain noradrenergic pathways.	Water	111-116	angiotensin II receptor type 1	Homo sapiens	9-12
33665266-7	2021	However, the results of electrolytes sodium-potassium tartrate (Na-K tartrate) and benzoic acid in alcohol-water (BAW) are reported for the polymerization of aniline onto MS [11].	Water	107-112	TANK binding kinase 1	Homo sapiens	64-68
9890898-9	1999	Tc confers binding specificity to TetR while Mg2+ is primarily responsible for induction: After binding to the imidazole Nepsilon of His100, Mg2+ is octahedrally coordinated to the 1,3-ketoenolate group of Tc and to three water molecules.	Water	222-227	mucin 7, secreted	Homo sapiens	45-48
33576101-1	2021	Aquaporin-2 plays a vital role in the human kidney as a water passage channel.	Water	56-61	aquaporin 2	Homo sapiens	0-11
33576101-8	2021	Moreover, by calculating the osmotic permeability and the potential of mean force (PMF) of each of the AQP2 monomers for wide/narrow states of the SF, it is seen that the selectivity filter at its narrow conformation can induce a much larger energy barrier for water molecules permeation, hindering the transport of water molecules remarkably.	Water	261-266	aquaporin 2	Homo sapiens	103-107
33576101-8	2021	Moreover, by calculating the osmotic permeability and the potential of mean force (PMF) of each of the AQP2 monomers for wide/narrow states of the SF, it is seen that the selectivity filter at its narrow conformation can induce a much larger energy barrier for water molecules permeation, hindering the transport of water molecules remarkably.	Water	316-321	aquaporin 2	Homo sapiens	103-107
33671254-0	2021	Reliable Sea Water Ro Operation with High Water Recovery and No-Chlorine/No-Sbs Dosing in Arabian Gulf, Saudi Arabia.	Water	13-18	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	9-12
33671254-0	2021	Reliable Sea Water Ro Operation with High Water Recovery and No-Chlorine/No-Sbs Dosing in Arabian Gulf, Saudi Arabia.	Water	42-47	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	9-12
9890898-9	1999	Tc confers binding specificity to TetR while Mg2+ is primarily responsible for induction: After binding to the imidazole Nepsilon of His100, Mg2+ is octahedrally coordinated to the 1,3-ketoenolate group of Tc and to three water molecules.	Water	222-227	mucin 7, secreted	Homo sapiens	141-144
33579884-6	2021	The PS/DFNB4 mouse models have shown that biallelic slc26a4 mutations lead to Na + and water retention in the endolymph during the perinatal period, which in turn induces degeneration of the stria vascularis and hearing loss.	Water	87-92	solute carrier family 26, member 4	Mus musculus	52-59
33591965-8	2021	This phenotype is associated with enhanced epithelial sodium channel (ENaC) activity that mediates Na+ and water reabsorption.	Water	107-112	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	34-68
9886922-0	1999	Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice.	Water	16-21	aquaporin 1	Mus musculus	64-75
33591965-8	2021	This phenotype is associated with enhanced epithelial sodium channel (ENaC) activity that mediates Na+ and water reabsorption.	Water	107-112	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	70-74
33012754-0	2021	Sensitive Gas Chromatography Detection of Nanomolar Hydroxylamine in Environmental Water by Fe(III) Oxidation.	Water	83-88	gastrin	Homo sapiens	10-13
9886922-1	1999	Aquaporin-1 (AQP1) water channels are expressed widely in epithelia and capillary endothelia involved in fluid transport.	Water	19-24	aquaporin 1	Mus musculus	0-11
33412444-5	2021	The adenosine triphosphate (ATP) concentration of bulk water in the pipe reactors increased from ~1.2 ng/L to almost above 5 ng/L when fed water switching to TP 2.	Water	55-60	transition protein 2	Homo sapiens	158-162
9886922-1	1999	Aquaporin-1 (AQP1) water channels are expressed widely in epithelia and capillary endothelia involved in fluid transport.	Water	19-24	aquaporin 1	Mus musculus	13-17
33503371-3	2021	The developed DE-TIP3 potential was better than LJ potential in reproducing the experimental water properties.	Water	93-98	suppressor of cytokine signaling 1	Homo sapiens	17-21
9886922-10	1999	Therefore, AQP1 provides a major route for osmotically driven water transport across the peritoneal barrier in peritoneal dialysis.	Water	62-67	aquaporin 1	Mus musculus	11-15
10872456-8	1999	Multifunctional aquaglyceroporins AQP3, AQP7, and AQP9 are permeated by water, glycerol, and some other solutes.	Water	72-77	aquaporin 7	Homo sapiens	40-44
33507761-7	2021	This work reports the first experimental investigation of high-performance known molecular structure AAs under industrially relevant conditions, showing that these molecules can reduce the interfacial tension and increase the gas hydrate-water contact angle, thereby minimizing the gas hydrate interparticle interactions.	Water	238-243	gastrin	Homo sapiens	226-229
33507761-7	2021	This work reports the first experimental investigation of high-performance known molecular structure AAs under industrially relevant conditions, showing that these molecules can reduce the interfacial tension and increase the gas hydrate-water contact angle, thereby minimizing the gas hydrate interparticle interactions.	Water	238-243	gastrin	Homo sapiens	282-285
33069027-1	2021	This work presents solution- and solid-state evidence of the enhancement of J-like aggregation of a cationic polythiophene (CPT) with isothiouronium functionalities (PT1), caused by a decrease in the polarity and hydrogen-bonding (H-bonding) capacity of the solvent, generated by using a 50:50 v/v 1,4-dioxane-water mixture (W-DI) instead of water.	Water	310-315	zinc finger protein 77	Homo sapiens	166-169
33069027-1	2021	This work presents solution- and solid-state evidence of the enhancement of J-like aggregation of a cationic polythiophene (CPT) with isothiouronium functionalities (PT1), caused by a decrease in the polarity and hydrogen-bonding (H-bonding) capacity of the solvent, generated by using a 50:50 v/v 1,4-dioxane-water mixture (W-DI) instead of water.	Water	342-347	zinc finger protein 77	Homo sapiens	166-169
33069027-5	2021	Our results show a clear correlation between the solution- and solid-state properties of PT1 in each solvent, further validating the use of the fluorescence excitation spectra to trace J-like aggregation of water-soluble conjugated polymeric fluorophores in solution.	Water	207-212	zinc finger protein 77	Homo sapiens	89-92
10522818-13	1999	Moreover, GLP-1 reduces food and water intake controlled by the brain, and inhibits gastric emptying.	Water	33-38	glucagon	Mus musculus	10-15
33579010-5	2021	An example is given of photochemical dissipative abiogenesis of adenine from the precursor HCN in water solvent within a fatty acid vesicle floating on a hot ocean surface and driven far from equilibrium by the incident UVC light.	Water	98-103	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	91-94
33443271-2	2021	It possesses no aggregation-induced emission (AIE) characteristics but can detect Cd2+ and Zn2+ ions selectively in the "off-on" mode based on the AIE of their complexes in the media of THF/HEPES and THF/H2O, respectively, which will provide a new strategy for target detection based on AIE.	Water	204-207	CD2 molecule	Homo sapiens	82-85
33443271-8	2021	Moreover, the detection of Cd2+ and Zn2+ ions was realized qualitatively via test paper and quantitatively in water.	Water	110-115	CD2 molecule	Homo sapiens	27-30
33245078-1	2021	Herein, an indirect SERS sensing assay was developed for the determination of glyphosate (Gly) in tap water.	Water	102-107	seryl-tRNA synthetase 1	Homo sapiens	20-24
33245078-8	2021	This SERS assay can be used for detection of Gly in tap water that can meet the needs of practical detection.	Water	56-61	seryl-tRNA synthetase 1	Homo sapiens	5-9
33854899-3	2021	Due to the coordinate and hydrogen bonds in the water-soluble polyacrylamide hydrogel, MoP is uniformly confined in a 3D porous NC to form ultrafine nanoparticles which facilitate the extreme exposure of abundant three-phase boundaries (MoP, NC, and electrolyte) for ionic binding and storage.	Water	48-53	opioid receptor mu 1	Homo sapiens	87-90
9878133-3	1999	The adsorbed cationic amphiphile molecules remaining on mica surfaces after rinsing with distilled water were found to be anchored to the surface by ion-exchange, replacing surface potassium and/or other cations.	Water	99-104	MHC class I polypeptide-related sequence A	Homo sapiens	56-60
32558151-1	2021	OBJECTIVES: Recent evidence has associated mood disorders with blood-brain barrier (BBB)/ neurovascular unit (NVU) dysfunction, and reduction in blood vessels coverage by the water channel aquaporin-4 (AQP4) immunoreactive astrocytes.	Water	175-180	aquaporin 4	Rattus norvegicus	202-206
33562593-3	2021	Here we report on the purification of Wsc1 by its trapping in water-soluble polymer-stabilized lipid nanoparticles, obtained with an amphipathic styrene-maleic acid (SMA) copolymer.	Water	62-67	Slg1p	Saccharomyces cerevisiae S288C	38-42
9886257-2	1999	MnSOD dismutates the superoxide anion (O2*-) derived from the reduction of molecular oxygen to hydrogen peroxide (H2O2), which is detoxified by glutathione peroxidase to water and molecular oxygen.	Water	170-175	superoxide dismutase 2	Homo sapiens	0-5
31999938-6	2021	Treatment with H2O2 decreased miR-126 expression in EPCs in a dose-dependent manner.	Water	15-19	microRNA 126b	Rattus norvegicus	30-37
31999938-8	2021	Overexpression of miR-126 enhanced the proliferation, migration, and tube formation of H2O2-treated EPCs.	Water	87-91	microRNA 126b	Rattus norvegicus	18-25
31999938-9	2021	MiR-126 overexpression also inhibited reactive oxygen species and malondialdehyde levels and enhanced superoxide dismutase levels, as well as increased angiopoietin (Ang)1 expression and decreased Ang2 expression in H2O2-treated EPCs.	Water	216-220	microRNA 126b	Rattus norvegicus	0-7
31999938-10	2021	Moreover, miR-126 participated in the regulation of phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (Akt)/ glycogen synthase kinase-3beta (GSK-3beta) and extracellular signal-regulated kinase (ERK)1/2 signaling in EPCs, where both pathways were activated after miR-126 overexpression in H2O2-treated EPCs.	Water	294-298	microRNA 126b	Rattus norvegicus	10-17
31999938-10	2021	Moreover, miR-126 participated in the regulation of phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (Akt)/ glycogen synthase kinase-3beta (GSK-3beta) and extracellular signal-regulated kinase (ERK)1/2 signaling in EPCs, where both pathways were activated after miR-126 overexpression in H2O2-treated EPCs.	Water	294-298	microRNA 126b	Rattus norvegicus	268-275
31999938-11	2021	Overall, we showed that miR-126 promoted the biological function of EPCs under H2O2-induced oxidative stress by activating the PI3K/Akt/GSK-3beta and ERK1/2 signaling pathway, which may serve as a new therapeutic approach to treat AMI.	Water	79-83	microRNA 126b	Rattus norvegicus	24-31
33387850-6	2021	water extract (CME) on RANKL-induced osteoclast differentiation in mouse bone marrow-derived macrophages (BMMs).	Water	0-5	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	23-28
10203001-8	1999	Additionally, samples with endotoxin contamination derived from the mains water had significantly higher counts of fecal coliforms, enterococci and Pseudomonas spp.	Water	74-79	histocompatibility minor 13	Homo sapiens	160-163
33338750-5	2021	Both AOC3 inhibitors (20 mg/kg, daily s.c. injections) were protective against STZ-induced pancreatic beta cell damage determined by insulin immunohistochemistry and radioimmunoassay, neuropathic cold hypersensitivity measured by paw withdrawal latency decrease from 0  C water, and retinal dysfunction detected by electroretinography.	Water	272-277	amine oxidase, copper containing 3	Rattus norvegicus	5-9
33359781-0	2021	Water treadmill training protects the integrity of the blood-spinal cord barrier following SCI via the BDNF/TrkB-CREB signalling pathway.	Water	0-5	cAMP responsive element binding protein 1	Rattus norvegicus	113-117
9852128-4	1998	Here we investigate the gating process of Kir1.1 channels exploiting their state-dependent modification by water-soluble oxidants and sulfhydryl reagents.	Water	107-112	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	42-48
33573038-1	2021	The flow behavior of gas in compressible and incompressible systems was investigated at an ambient temperature in an air-water system and at an operating process temperature in the IronArc system, using computational fluid dynamics.	Water	121-126	gastrin	Homo sapiens	21-24
32652708-8	2021	Our results indicate a particular role of NDRG2 in maintaining astrocytic polarization to facilitate Na+ and water transfer balance and to protect the brain from ischemic edema.	Water	109-114	N-myc downstream regulated gene 2	Mus musculus	42-47
33468681-1	2021	Glacial landforms, including lobate debris aprons, are a global water ice reservoir on Mars preserving ice from past periods when high orbital obliquity permitted nonpolar ice accumulation.	Water	64-69	methionyl-tRNA synthetase 1	Homo sapiens	87-91
33514100-5	2021	According to these data, the CO2 enclathration in the sII clathrate cages is a stabilizing process, either by considering both guest-host and host-host interactions in the complete unit cell or only the guest-water energies for the individual clathrate-like sII cages.	Water	209-214	transcription elongation factor A1	Homo sapiens	54-57
9951557-6	1998	Previous administration of the AT1 receptor antagonist DuP753 into the SON decreased water (65%, N = 10, P &lt; 0.01) and sodium intake (81%, N = 8, P &lt; 0.01) induced by the injection of ANG II (10 nmol) into the MSA.	Water	85-90	angiotensin II receptor, type 1a	Rattus norvegicus	31-34
9916876-2	1998	PLP was solubilized in water or in an aqueous solution of 1% 10-tridecyl ether (TDE), a non-ionic detergent used in membrane protein research.	Water	23-28	proteolipid protein 1	Rattus norvegicus	0-3
33393578-1	2021	Benzo[a]pyrene (Bap) is one of the main organic pollutants in the atmospheric haze that is rich in fine water drops and particulate matters.	Water	104-109	prohibitin 2	Homo sapiens	16-19
33393578-2	2021	The understanding of the Bap"s form in water is of great importance to unveil its real biological effects toward the respiratory system.	Water	39-44	prohibitin 2	Homo sapiens	25-28
33393578-4	2021	Herein, we found that Bap existed as self-aggregated nanoclusters of tunable sizes rather than as dissolved molecules in water and different sized nanoclusters illustrated varied cytotoxicity.	Water	121-126	prohibitin 2	Homo sapiens	22-25
33405506-1	2021	Gas management during electrocatalytic water splitting is vital for improving the efficiency of clean hydrogen production.	Water	39-44	gastrin	Homo sapiens	0-3
33305581-8	2021	Additionally, the high performance of the preconcentration system leads to detection limits below 435 cells mL-1 after 10 min in aquaponic water samples.	Water	139-144	L1 cell adhesion molecule	Mus musculus	108-112
9916876-5	1998	Whereas only 37.5% of the eight rats immunized with 500 microg of water-solubilized PLP developed minor clinical signs (tail weakness or paralysis).	Water	66-71	proteolipid protein 1	Rattus norvegicus	84-87
9878331-7	1998	The EGF-treated group exhibited significantly increased mucosal villous height, crypt cell proliferation, glucose and water absorption, and expression of SGLT1 protein compared to the control group.	Water	118-123	epidermal growth factor like 1	Rattus norvegicus	4-7
32975004-5	2021	X-ray crystallography supports a role for the selectivity based on reorganization of a non-conserved lysine and displacement of an additional structured water  in the BRD4 D1 binding site relative to our prior lead.	Water	153-158	bromodomain containing 4	Mus musculus	167-171
33403379-4	2021	In this article, we have investigated the detailed mechanism and kinetics of the H2O catalyzed nitrogen reduction reaction (NRR) over bare and TiO2 doped Ru5 clusters in conjunction with DFT and TST calculations.	Water	81-84	thiosulfate sulfurtransferase	Homo sapiens	195-198
9819374-2	1998	In rats, 24 h water restriction increased mean urinary osmolality (Uosm) from 2, 179+/-153 mOsm/kg to 2,944+/-294 mOsm/kg (P &lt; 0.001) and was associated with significant (P &lt; 0.05) increases in the papillary activity of c-Jun NH2-terminal protein kinase (JNK) by 22%, extracellular signal-regulated protein kinase (ERK) by 49%, and p38 MAPK by 15%.	Water	14-19	mitogen activated protein kinase 14	Rattus norvegicus	338-341
33521096-6	2020	Early water deprivation directly affected the brain proopiomelanocortin (POMC) and hepatic glucocorticoid receptors (GR) expression and induced significant changes in various aquaporins (AQP1, AQP2, AQP4, and AQP9).	Water	6-11	aquaporin 2	Homo sapiens	193-197
33207513-12	2021	We conclude that lateral transport of riverine and mangrove-derived DIC, TAlk, and DOC affect CO2 dynamics and air-water fluxes in seagrass and coral ecosystems.	Water	115-120	bone morphogenetic protein receptor type 2	Homo sapiens	73-77
33428732-0	2021	Adipose-Derived Stem Cells Improve the Aging Skin of Nude Mice by Promoting Angiogenesis and Reducing Local Tissue Water.	Water	115-120	WD and tetratricopeptide repeats 1	Mus musculus	0-7
9819374-3	1998	Conversely, 24 h of water-loading (Uosm 473+/-33 mOsm/kg) caused suppression of JNK activity by 43% (P &lt; 0.001), ERK by 39% (P &lt; 0.05), and p38 MAPK by 26% (P &lt; 0.05).	Water	20-25	mitogen activated protein kinase 14	Rattus norvegicus	146-149
9851580-8	1998	The mucosal histamine content of both Wistar rats and Ws/Ws rats, was 20% lower, whereas histidine decarboxylase activity in the gastric mucosa was enhanced by two-fold, during exposure to stress for 4 h. These findings indicate that water immersion stress causes a biphasic increase in plasma histamine concentration in Wistar rats; the initial acute increase in plasma histamine level originates from mast cells, and the second, sustained increase is attributed to enterochromaffin-like cells.	Water	234-239	histidine decarboxylase	Rattus norvegicus	89-112
32830385-5	2021	The presence of an equivalent of water then facilitated the formation of P(OH) 2 OPh and the amine, R"NH 2 , subsequently abstracted a proton from it to yield [(PhO)PH(O)O] - [R"NH 3 ] + .	Water	33-38	NLR family pyrin domain containing 4	Homo sapiens	100-106
33322895-1	2021	The photocatalytic reduction of water to form hydrogen gas (H2) is a promising approach to collect, convert, and store solar energy.	Water	32-37	gastrin	Homo sapiens	55-58
33401564-0	2021	Hole-Type Spacers for More Stable Shale Gas-Produced Water Treatment by Forward Osmosis.	Water	53-58	gastrin	Homo sapiens	40-43
33401564-4	2021	During shale gas produced water treatment, a severe flux decline was observed for both spacer designs due to the formation of barium sulfate scaling.	Water	26-31	gastrin	Homo sapiens	13-16
33188750-2	2021	Larvae (L2) were exposed to 105, 106, 107, and 108 propagules mL-1 water suspension.	Water	67-72	L1 cell adhesion molecule	Mus musculus	62-66
32896640-8	2021	The levels of IL-1b, IL-18, and TSLP exhibited positive correlations with the AD severity index (Scoring AD index) and skin transepidermal water loss (TEWL), whereas an inverse correlation between IL-1a and Scoring AD index and IL-1a and TEWL was found.	Water	139-144	thymic stromal lymphopoietin	Homo sapiens	32-36
33297054-1	2021	The detection of composition or pollution trends of vast environmental water areas, from a river, lake or sea, requires the determination of the mean concentration of the studied component in the studied area at defined depth in, at least, two occasions.	Water	71-76	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	106-109
33297055-1	2021	Zinc (Zn2+) and cadmium (Cd2+) in water pose serious threats to human health and the environment.	Water	34-39	CD2 molecule	Homo sapiens	25-28
33545810-4	2021	The scaffolds were expected to combine the excellent mechanical strength and biodegradability of PLLA, the good bioactivity of nHA, and the water solubility and antitumor properties of MET.	Water	140-145	SAFB like transcription modulator	Homo sapiens	185-188
33545810-5	2021	The PLLA/nHA/MET scaffolds showed improved cell adhesion, appropriate porosity, good biocompatibility and osteogenic-induced ability in vitro because metformin improves water solubility and promotes the osteogenic differentiation of cells within the scaffold.	Water	169-174	SAFB like transcription modulator	Homo sapiens	13-16
33000422-4	2021	Administration of a water-soluble, bioavailable form of this GSK-3 inhibitor (Ro3303544-Cl) in a severe SCI mouse model revealed the increased expression of bIII-tubulin in the injury epicenter.	Water	20-25	glycogen synthase kinase 3 beta	Mus musculus	61-66
32905588-6	2020	Miz1 mutant exhibited deficient hydrotropism in the oblique orientation but normal root elongation towards the water in a vertical orientation.	Water	111-116	MIZU-KUSSEI-like protein (Protein of unknown function, DUF617)	Arabidopsis thaliana	0-4
32905588-9	2020	Additionally, gravity facilitated roots" search for vertically-oriented water, because the miz1/aux1 double-mutant showed attenuated root elongation towards the water in a vertical orientation, in contrast to miz1.	Water	72-77	MIZU-KUSSEI-like protein (Protein of unknown function, DUF617)	Arabidopsis thaliana	91-95
32905588-9	2020	Additionally, gravity facilitated roots" search for vertically-oriented water, because the miz1/aux1 double-mutant showed attenuated root elongation towards the water in a vertical orientation, in contrast to miz1.	Water	161-166	MIZU-KUSSEI-like protein (Protein of unknown function, DUF617)	Arabidopsis thaliana	91-95
33424796-0	2020	Simulation of Microbial Response to Accidental Diesel Spills in Basins Containing Brackish Sea Water and Sediment.	Water	95-100	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	91-94
33370882-8	2020	Under climate change, water scarcity in these sub-catchments will exhibit high dependency (Kendall tau correlation coefficient = 0.84) on water-use patterns than on water availability.	Water	22-27	microtubule associated protein tau	Homo sapiens	99-102
33370882-8	2020	Under climate change, water scarcity in these sub-catchments will exhibit high dependency (Kendall tau correlation coefficient = 0.84) on water-use patterns than on water availability.	Water	138-143	microtubule associated protein tau	Homo sapiens	99-102
33370882-8	2020	Under climate change, water scarcity in these sub-catchments will exhibit high dependency (Kendall tau correlation coefficient = 0.84) on water-use patterns than on water availability.	Water	138-143	microtubule associated protein tau	Homo sapiens	99-102
32987083-4	2020	Both concentrations of extract (500 or 1000 mug mL-1) increased the thickness, opacity, and water vapor transmission rate (WVTR) of the films when compared to the film without extract, but decreased the solubility.	Water	92-97	L1 cell adhesion molecule	Mus musculus	48-52
33327535-9	2020	The low-cost and facile fabrication of photothermal based water production presents a potential solution to single step drinking water supply from various resources of the sea, the lakes and mixtures of emulsified oil and industrial wastewater.	Water	58-63	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	172-175
33327535-9	2020	The low-cost and facile fabrication of photothermal based water production presents a potential solution to single step drinking water supply from various resources of the sea, the lakes and mixtures of emulsified oil and industrial wastewater.	Water	129-134	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	172-175
33287699-12	2020	Spatial variation of unimproved water coverage was observed with high coverage observed at Amhara, Afar, Southern Nations Nationalities and People and Somalia regions.	Water	32-37	aldo-keto reductase family 7 member A2	Homo sapiens	99-103
32563901-6	2020	The RLS-mFP has excellent separation performance with the separation flux for surfactant-stabilized oil-in-water and water-in-oil emulsions achieving 1035 and 3570 L m-2 h-1 respectively only under gravity.	Water	107-112	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	Mus musculus	8-11
32563901-6	2020	The RLS-mFP has excellent separation performance with the separation flux for surfactant-stabilized oil-in-water and water-in-oil emulsions achieving 1035 and 3570 L m-2 h-1 respectively only under gravity.	Water	117-122	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	Mus musculus	8-11
32563901-6	2020	The RLS-mFP has excellent separation performance with the separation flux for surfactant-stabilized oil-in-water and water-in-oil emulsions achieving 1035 and 3570 L m-2 h-1 respectively only under gravity.	Water	117-122	H1.5 linker histone, cluster member	Homo sapiens	170-173
34043488-8	2022	A 400 ns MD simulations were run for WT cyt c and its mutant M80G in water using GROMOS96 force field.	Water	69-74	cytochrome c, somatic	Equus caballus	40-45
33084194-1	2020	In this research work, a water-soluble polysaccharide (LAP) isolated from the fruits of Lycium arabicum was investigated.	Water	25-30	LAP	Homo sapiens	55-58
32736241-6	2020	Owing to the ample hydrophilic chemical groups and tunable molecular transport channels in COFs, the modified membranes yielded almost twice higher water flux (about 200 L m-2 h-1 bar) than the pristine membranes with simultaneously enhanced rejection of water pollutants (i.e., dyes).	Water	148-153	H1.5 linker histone, cluster member	Homo sapiens	176-179
32971453-5	2020	Whereas, the highest concentration of CAP in leachates was detected under 10 cm standing water (12.19 ng mL-1).	Water	89-94	L1 cell adhesion molecule	Mus musculus	105-109
32737778-1	2020	Solute transport models and hydraulic indicators are commonly used to assess the flow pattern of free water surface-constructed wetlands (FWS CWs).	Water	102-107	FWS	Homo sapiens	138-141
33242053-3	2020	Mycoprotein at 30 mg mL-1 concentration significantly reduced lipolysis after 60 min of simulated intestinal digestion with oil-in-water emulsion (P < 0.001) or 10 min of incubation with tributyrin (P < 0.01).	Water	131-136	L1 cell adhesion molecule	Mus musculus	21-25
33445907-3	2021	It was found that the distribution of gas molecules at the solid-water interface is regulated by the direction of the external electric field.	Water	65-70	gastrin	Homo sapiens	38-41
33431895-5	2021	The characterization shows that PFK-1 water matrix dynamics are crucial for examining how respiration (PFK-1 tetramer complex breathing) rates respond to temperature change through a water and nano-channel network created by the enzyme folding surfaces, at both short and long (evolutionary) timescales.	Water	38-43	phosphofructokinase, muscle	Homo sapiens	32-37
33431895-5	2021	The characterization shows that PFK-1 water matrix dynamics are crucial for examining how respiration (PFK-1 tetramer complex breathing) rates respond to temperature change through a water and nano-channel network created by the enzyme folding surfaces, at both short and long (evolutionary) timescales.	Water	38-43	phosphofructokinase, muscle	Homo sapiens	103-108
33431895-5	2021	The characterization shows that PFK-1 water matrix dynamics are crucial for examining how respiration (PFK-1 tetramer complex breathing) rates respond to temperature change through a water and nano-channel network created by the enzyme folding surfaces, at both short and long (evolutionary) timescales.	Water	183-188	phosphofructokinase, muscle	Homo sapiens	32-37
33431895-5	2021	The characterization shows that PFK-1 water matrix dynamics are crucial for examining how respiration (PFK-1 tetramer complex breathing) rates respond to temperature change through a water and nano-channel network created by the enzyme folding surfaces, at both short and long (evolutionary) timescales.	Water	183-188	phosphofructokinase, muscle	Homo sapiens	103-108
33431895-6	2021	We not only reveal the nano-channel water network of PFK-1 tetramer hydration topography but also clarify how temperature drives the underlying respiration rates by mapping the channels of water diffusion with distinct dynamics in space and time.	Water	36-41	phosphofructokinase, muscle	Homo sapiens	53-58
33431895-6	2021	We not only reveal the nano-channel water network of PFK-1 tetramer hydration topography but also clarify how temperature drives the underlying respiration rates by mapping the channels of water diffusion with distinct dynamics in space and time.	Water	189-194	phosphofructokinase, muscle	Homo sapiens	53-58
33431895-7	2021	The results show that the PFK-1 assembly tetramer possesses a sustainable capacity in the regulation of the water network toward metabolic rates.	Water	108-113	phosphofructokinase, muscle	Homo sapiens	26-31
33435201-5	2021	The results of the study show that combining TDR and MPS-6 sensors can be used to estimate plant-available water and SWRC, with a mean difference of -0.03 to 0.23 m3m-3 between the modeled data and laboratory data, which could be caused by the sensors" lack of site-specific calibration or possible air entrapment of field soil.	Water	107-112	arylsulfatase B	Homo sapiens	53-58
33290472-8	2021	Complexes [VIVOL3(CH3OH)] (3), [CuL3(H2O)] (7) and [CuL5(H2O)] (8) were further evaluated and their mechanism of action was determined to be apoptosis, evidenced by AnnexinV staining and the increase in caspase 3/7 activity.	Water	57-60	cullin 5	Homo sapiens	52-56
33188750-18	2021	oil-in-water emulsions at 107 propagules mL-1 yielded better results than the water suspensions, the larvae survival rate was 2 days for both propagules in oil-in-water emulsion.	Water	7-12	L1 cell adhesion molecule	Mus musculus	41-45
33462558-7	2021	The lower salinity of the Caspian Sea compared to the Oman Sea is the main reason, which lead to reduce in the capital cost of the RO membrane (62% difference), cost of the intake and pretreatment (20%), and cost of membrane elements replacement (13%) regardless of water transfer cost.	Water	266-271	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	34-37
33462558-7	2021	The lower salinity of the Caspian Sea compared to the Oman Sea is the main reason, which lead to reduce in the capital cost of the RO membrane (62% difference), cost of the intake and pretreatment (20%), and cost of membrane elements replacement (13%) regardless of water transfer cost.	Water	266-271	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	59-62
33642550-1	2021	Glucosyl hesperidin (GH) is a water-soluble derivative of hesperidin, a citrus flavonoid.	Water	30-35	growth hormone	Mus musculus	21-23
32880045-6	2021	The principal component analysis (PCA) revealed the generation of three components (PC1, PC2, and PC3) with higher eigenvalues of 3 or more (3-6) explaining 40, 21, and 17% of the overall variance in water quality data sets, respectively.	Water	200-205	proprotein convertase subtilisin/kexin type 1	Homo sapiens	84-87
32880045-6	2021	The principal component analysis (PCA) revealed the generation of three components (PC1, PC2, and PC3) with higher eigenvalues of 3 or more (3-6) explaining 40, 21, and 17% of the overall variance in water quality data sets, respectively.	Water	200-205	proprotein convertase subtilisin/kexin type 1	Homo sapiens	98-101
33449735-0	2020	Nonlinear Spectral Synthesis of Soliton Gas in Deep-Water Surface Gravity Waves.	Water	52-57	gastrin	Homo sapiens	40-43
33449735-3	2020	We report a controlled synthesis of a dense soliton gas in deep-water surface gravity waves using the tools of nonlinear spectral theory [inverse scattering transform (IST)] for the one-dimensional focusing nonlinear Schrodinger equation.	Water	64-69	gastrin	Homo sapiens	52-55
33449735-4	2020	The soliton gas is experimentally generated in a one-dimensional water tank where we demonstrate that we can control and measure the density of states, i.e., the probability density function parametrizing the soliton gas in the IST spectral phase space.	Water	65-70	gastrin	Homo sapiens	12-15
33449735-4	2020	The soliton gas is experimentally generated in a one-dimensional water tank where we demonstrate that we can control and measure the density of states, i.e., the probability density function parametrizing the soliton gas in the IST spectral phase space.	Water	65-70	gastrin	Homo sapiens	217-220
33458518-2	2021	In this study, polysaccharides from B. striata (BSP) were extracted by hot water.	Water	75-80	black spleen	Mus musculus	48-51
33374101-9	2020	The main conclusion of this review was that TMC technology, although promising, will only be competitive when the recovered water quality is high and/or the recovered energy has some energetic value (water temperature above 50  C).	Water	124-129	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	44-47
33374101-9	2020	The main conclusion of this review was that TMC technology, although promising, will only be competitive when the recovered water quality is high and/or the recovered energy has some energetic value (water temperature above 50  C).	Water	200-205	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	44-47
33345753-8	2020	The depth analysis of intermolecular interactions showed that the interactions between water molecules and ligand play a crucial role in hDHFR inhibition.	Water	87-92	dihydrofolate reductase	Homo sapiens	137-142
33008599-2	2020	SECR belongs to the class B G-protein-coupled receptors and is involved in various processes, such as regulation of the pH of the duodenal content, food intake, and water homeostasis.	Water	165-170	secretin receptor	Homo sapiens	0-4
33096553-9	2020	High TC1 scores represented a diet rich in salad, fruit, vegetables, poultry and seafood, and plain water or tea to drink.	Water	100-105	transcobalamin 1	Homo sapiens	5-8
33521463-0	2021	Au/Ag/Cu-Mixed Catalysts for the Eco-Friendly Oxidation of 5-Hydroxymethylfurfural and Related Compounds to Carboxylic Acids under Atmospheric Oxygen in Water.	Water	153-158	ciliogenesis associated kinase 1	Homo sapiens	33-36
33170004-3	2020	Another type of 2D MOF of [Ln2(ipO)2(H2O)4] 2H2O [Ln = Gd (3), Dy (4)] was thus obtained.	Water	37-40	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	27-36
33335604-8	2020	Interestingly, upon aggregation in water-containing media, H, Me and t-Bu show a slight red-shift of the emission and a blue-shift is observed for OMe, SMe and NMe2.	Water	35-40	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	160-164
32886187-5	2020	The TP53-mutant frequency after glycidamide exposure (1.1 mM for 24 h, n = 198) was 9% compared with 0% in cultures treated with acrylamide [1.5 (n = 24) or 3 mM (n = 6) for 48 h] and untreated vehicle (water) controls (n = 36).	Water	203-208	transformation related protein 53	Mus musculus	4-8
31905030-9	2020	The inhibition of JNK and p38MAPK pathways induced by cZNF609 silence was impeded by miR-145 silence.Conclusion: The protective function of cZNF609 silence in H2O2-injured HaCaT cells was revealed in vitro.	Water	159-163	microRNA 145	Homo sapiens	85-92
32864834-4	2020	Meanwhile, the water solubility of CP-beta-CD is improved dramatically to 816 mg mL-1 , which is 440 times as that of unmodified beta-CD.	Water	15-20	L1 cell adhesion molecule	Mus musculus	81-85
33402876-5	2020	We observe, in situ, the direct displacement of oil and water by gas as well as gas-oil-water double displacement.	Water	56-61	gastrin	Homo sapiens	65-68
33402876-5	2020	We observe, in situ, the direct displacement of oil and water by gas as well as gas-oil-water double displacement.	Water	88-93	gastrin	Homo sapiens	80-83
33402876-6	2020	The use of local in situ measurements and an energy balance approach to determine fluid-fluid contact angles alongside the quantification of capillary pressures and pore occupancy indicate that the wettability order is oil-gas-water from most to least wetting.	Water	227-232	gastrin	Homo sapiens	223-226
33260878-5	2020	PDF_OP and PIs_PDF_OP showed a significantly lower water absorption capacity than PIs OP and SIs_OP, whereas pea-based extrudates showed high oil absorption capacity, which could be convenient to facilitate the inclusion of oil and fat in the final formulation.	Water	51-56	peptide deformylase, mitochondrial	Homo sapiens	0-3
33241485-4	2020	The aim of this study is to test the suitability of the powerful machine learning (ML) algorithm, random forest (RF), to provide information on water quality parameters for the Tri An Reservoir (TAR).	Water	144-149	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	177-180
33238639-3	2020	Meanwhile, Cs, Se, and Te were enriched in the phase separated potassium-rich materials on glass surface, which were extracted by water.	Water	130-135	squalene epoxidase	Homo sapiens	15-17
33275022-2	2020	We build an experimental apparatus to test the predicted long-time 1/tau scaling of the irreversible entropy generation in the finite-time (tau) thermodynamic process by compressing dry air in a temperature-controlled water bath.	Water	218-223	microtubule associated protein tau	Homo sapiens	69-72
33275022-2	2020	We build an experimental apparatus to test the predicted long-time 1/tau scaling of the irreversible entropy generation in the finite-time (tau) thermodynamic process by compressing dry air in a temperature-controlled water bath.	Water	218-223	microtubule associated protein tau	Homo sapiens	140-143
9877537-6	1998	The contribution of tap water from the water system of the city of Graz, Austria to the concentrations of trace elements in the formulas ranges from 45% for Pb to 0.2% for Rb and is negligible, for instance, for Cd, Cs, La, Mo, and Sn.	Water	24-29	tracheal antimicrobial peptide	Bos taurus	20-23
32619666-1	2020	Three water-soluble polysaccharides (AMAP-1, AMAP-2 and AMAP-3) were isolated and purified from Atractylodis Macrocephalae Rhizoma by using the combination of ion-exchange chromatography and gel permeation chromatography.	Water	6-11	MYCBP associated protein	Mus musculus	37-43
33186392-0	2020	Sustainable batching water options for one-part alkali-activated slag mortar: Sea water and reverse osmosis reject water.	Water	21-26	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	78-81
9585485-11	1998	MBT sulfoxide, from oxidation of MBT with magnesium monoperoxyphthalate in water, is one of the most potent inhibitors known for mALDH and yeast ALDH in vitro (IC50 0.08-0.09 microM).	Water	75-80	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	129-134
33204889-8	2020	The obtained results show that transferring Red Sea water to Dead Sea would lead to dilution of Dead Sea brine and affects significantly the investigated mixed water physical properties.	Water	160-165	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	48-51
33204889-8	2020	The obtained results show that transferring Red Sea water to Dead Sea would lead to dilution of Dead Sea brine and affects significantly the investigated mixed water physical properties.	Water	160-165	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	66-69
9585485-11	1998	MBT sulfoxide, from oxidation of MBT with magnesium monoperoxyphthalate in water, is one of the most potent inhibitors known for mALDH and yeast ALDH in vitro (IC50 0.08-0.09 microM).	Water	75-80	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	130-134
33204889-8	2020	The obtained results show that transferring Red Sea water to Dead Sea would lead to dilution of Dead Sea brine and affects significantly the investigated mixed water physical properties.	Water	160-165	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	66-69
33204889-9	2020	Water mixing project is expected to cease the halite precipitation phenomenon due to the development of stratification in the Dead Sea and halite dissolution.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	131-134
9545259-10	1998	In oocytes of comparable water and urea permeability coexpressing AQP1 (permeable to water, not urea) and UT2 (permeable to urea, not water), sigmaurea = 1.	Water	85-90	aquaporin 1	Rattus norvegicus	66-70
9545259-10	1998	In oocytes of comparable water and urea permeability coexpressing AQP1 (permeable to water, not urea) and UT2 (permeable to urea, not water), sigmaurea = 1.	Water	85-90	aquaporin 1	Rattus norvegicus	66-70
9560000-1	1998	Solution conformation of cyclo(Gly1-His2-Phe3-Arg4-Trp5-Gly6) and its D-Phe analog corresponding to the message sequence [Gly-alpha-MSH5-10] of alpha-MSH has been studied by 1D and 2D proton magnetic resonance spectroscopy in dimethyl sulfoxide (DMSO)-d6 solution and in a DMSO-d6/H2O cryoprotective mixture.	Water	281-284	threonine aldolase 1, pseudogene	Homo sapiens	31-35
33225123-0	2020	Estimation of Gas Holdup Using the Gassed to Ungassed Power Ratio of an Oxygen-Water System in a Stirred and Sparged Tank Contactor.	Water	79-84	gastrin	Homo sapiens	14-17
33688142-0	2020	Amnesia Following Hot Water Bath from Gas Geyser.	Water	22-27	gastrin	Homo sapiens	38-41
9560000-1	1998	Solution conformation of cyclo(Gly1-His2-Phe3-Arg4-Trp5-Gly6) and its D-Phe analog corresponding to the message sequence [Gly-alpha-MSH5-10] of alpha-MSH has been studied by 1D and 2D proton magnetic resonance spectroscopy in dimethyl sulfoxide (DMSO)-d6 solution and in a DMSO-d6/H2O cryoprotective mixture.	Water	281-284	dihydrolipoamide dehydrogenase	Homo sapiens	41-45
9530264-10	1998	Divergent regulation of COX-2 in cortex and medulla by dietary salt suggests that prostaglandins in different kidney regions serve different functions, with medullary production playing a role in promoting the excretion of salt and water in volume overload, whereas cortical prostaglandins may protect glomerular circulation in volume depletion.	Water	232-237	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	24-29
32741756-0	2020	Changes in the ballast water tank bacterial community during a trans-sea voyage: Elucidation through next generation DNA sequencing.	Water	23-28	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	69-72
9548588-0	1998	Interaction of pulmonary surfactant protein A with dipalmitoylphosphatidylcholine and cholesterol at the air/water interface.	Water	109-114	surfactant protein A1	Homo sapiens	15-45
32914211-1	2020	Crystallin zeta (CRYZ) is a phylogenetically restricted water-soluble protein and provides cytoprotection against oxidative stress via multiple mechanisms.	Water	56-61	crystallin, zeta	Mus musculus	0-15
32914211-1	2020	Crystallin zeta (CRYZ) is a phylogenetically restricted water-soluble protein and provides cytoprotection against oxidative stress via multiple mechanisms.	Water	56-61	crystallin, zeta	Mus musculus	17-21
9551103-10	1998	That PI3-SH3 folds slowly (time constant 2.8 seconds in H2O at 20 degrees C) indicates that slow refolding is not always a consequence of kinetic traps but may be observed even when a protein appears to fold via a simple, two-state mechanism.	Water	56-59	peptidase inhibitor 3	Homo sapiens	5-8
33078936-2	2020	On the basis of these state-selected sigma curves (sigma versus Ecm plots) observed, three reaction product channels, VO+ + H2, VH+ + OH, and VOH+ + H, from the V+ + H2O reaction are unambiguously identified.	Water	166-169	multimerin 1	Homo sapiens	64-67
33078936-7	2020	This experiment shows that the V+ + H2O reaction can be controlled effectively to produce predominantly the VO+ + H2 channel via the V+(a3FJ) + H2O reaction at low Ecm"s (<=0.1 eV) and that the ion-molecule reaction dynamics can be altered readily by selecting the electronic state of V+ cation.	Water	36-39	multimerin 1	Homo sapiens	164-167
9519708-5	1998	GLP-1 is produced in the brain, and intracerebroventricular GLP-1 in rodents is a potent inhibitor of food and water intake.	Water	111-116	glucagon like peptide 1 receptor	Homo sapiens	0-5
33086623-5	2020	Modelling results revealed that blaCTX-M-15-producing E. coli concentrations reduced downstream from the discharge source, with ~ 30% of the source concentration capable of dispersing through the estuary to the coast, taking ~36 h. Offshore, the concentration simulated at key shellfisheries and bathing water sites ranged from 1.4% to 10% of the upstream input, depending on the distance offshore and tidal regime, persisting in the water column for over a week.	Water	304-309	beta-lactamase	Escherichia coli	32-43
33086623-5	2020	Modelling results revealed that blaCTX-M-15-producing E. coli concentrations reduced downstream from the discharge source, with ~ 30% of the source concentration capable of dispersing through the estuary to the coast, taking ~36 h. Offshore, the concentration simulated at key shellfisheries and bathing water sites ranged from 1.4% to 10% of the upstream input, depending on the distance offshore and tidal regime, persisting in the water column for over a week.	Water	434-439	beta-lactamase	Escherichia coli	32-43
9519708-5	1998	GLP-1 is produced in the brain, and intracerebroventricular GLP-1 in rodents is a potent inhibitor of food and water intake.	Water	111-116	glucagon like peptide 1 receptor	Homo sapiens	60-65
32931478-5	2020	Genetic ablation of TRPV4 resulted in reduced expression of the water conducting aquaporin-5 (AQP-5) channel in ATI cells.	Water	64-69	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	20-25
9457891-0	1998	Direct observation of HO2/O2- free radicals generated in water by a high-linear energy transfer pulsed heavy-ion beam.	Water	57-62	heme oxygenase 2	Homo sapiens	22-25
9457891-1	1998	The formation and decay of HO2/O2- radical from the radiolysis of water by heavy 36S16+ ions (2.7 GeV) have been observed by time-resolved absorption spectroscopy at 260 nm.	Water	66-71	heme oxygenase 2	Homo sapiens	27-30
33053878-0	2020	Comparing Fragment Binding PosesPrediction Using HSP90 as a Key Study: When Bound Water Makes the Difference.	Water	82-87	heat shock protein 90 alpha family class A member 1	Homo sapiens	49-54
9457891-3	1998	In deaerated water, for a linear energy transfer (LET) of 250 eV/nm, the yield of HO2/O2- is (6 +/- 2) x 10(-9) mol J-1.	Water	13-18	heme oxygenase 2	Homo sapiens	82-85
18726267-7	1998	In R22L TCS, two water molecules occupy the space left by Arg changed to Leu.	Water	17-22	treacle ribosome biogenesis factor 1	Homo sapiens	8-11
33030091-1	2022	Human aquaporin-2 (AQP2) is the principal water channel in the human kidney.	Water	42-47	aquaporin 2	Homo sapiens	6-17
33030091-1	2022	Human aquaporin-2 (AQP2) is the principal water channel in the human kidney.	Water	42-47	aquaporin 2	Homo sapiens	19-23
33030091-4	2022	In this paper, the gating effects of selectivity filter (SF) as wide/narrow states on the mechanism and dynamics of water permeation within the wild-type AQP2 and two NDI causing mutants as AQP2-V168M and AQP2-G64R are studied for the first time.	Water	116-121	aquaporin 2	Homo sapiens	154-158
33030091-4	2022	In this paper, the gating effects of selectivity filter (SF) as wide/narrow states on the mechanism and dynamics of water permeation within the wild-type AQP2 and two NDI causing mutants as AQP2-V168M and AQP2-G64R are studied for the first time.	Water	116-121	aquaporin 2	Homo sapiens	190-194
33030091-4	2022	In this paper, the gating effects of selectivity filter (SF) as wide/narrow states on the mechanism and dynamics of water permeation within the wild-type AQP2 and two NDI causing mutants as AQP2-V168M and AQP2-G64R are studied for the first time.	Water	116-121	aquaporin 2	Homo sapiens	190-194
9498680-3	1998	The suitability of the method for profile analysis of PAH metabolites is shown by analysing a smokers urine after enzymatic cleavage (and additionally after spiking with the target analytes) and spiked water.	Water	202-207	phenylalanine hydroxylase	Homo sapiens	54-57
32914956-1	2020	While static electric fields have been effective in controlling ice nucleation, the highest freezing temperature (Tf) of water that can be achieved in an electric field (E) is still uncertain.	Water	121-126	coagulation factor III, tissue factor	Homo sapiens	114-116
33266313-0	2020	Influence of Acrylic Acid and Tert-Dodecyl Mercaptan in the Adhesive Performance of Water-Based Acrylic Pressure-Sensitive Adhesives.	Water	84-89	telomerase reverse transcriptase	Homo sapiens	30-34
33266313-5	2020	In this study is described how adhesive properties of water-based PSA were affected by varying the amount of functional monomer acrylic acid (AA) and chain transfer agent, tert-dodecyl mercaptan (TDM).	Water	54-59	telomerase reverse transcriptase	Homo sapiens	172-176
9472476-2	1998	Although MIP has some intrinsic water and glycerol permeability and can form a gap junction like channels in the reconstituted systems, its role in the lens remained enigmatic.	Water	32-37	major intrinsic protein of lens fiber	Bos taurus	9-12
33125009-5	2020	The limits of detection and quantification were found from 0.66 to 20 ng mL-1 and from 2.0 to 63 ng mL-1, respectively, values that are compatible with the level required in wash water analysis.	Water	179-184	L1 cell adhesion molecule	Mus musculus	100-104
32380409-0	2020	Characterization of Organic Matter in Water from Oil and Gas Wells Hydraulically Fractured with Recycled Water.	Water	105-110	gastrin	Homo sapiens	57-60
9537293-5	1998	First, P450arom activity was measured in pachytene spermatocytes, round spermatids, and a mixture of round spermatids, elongating spermatids, and residual bodies using the tritiated water (3H2O) assay.	Water	182-187	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	7-15
33023196-7	2020	The solubility of the alpha-M/HP-beta-CD CX in water linearly increased about 11.7-fold compared to alpha-M alone, and by 3.5-fold compared to the alpha-M/HP-beta-CD physical mixture (alpha-M/HP-beta-CD CX PM).	Water	47-52	adrenocortical dysplasia	Mus musculus	33-40
33283117-0	2020	Study on Eliminating the Water Blocking Effect in Coal Seams Using Gas-Wetting Reversal Technology.	Water	25-30	gastrin	Homo sapiens	67-70
33283117-1	2020	To eliminate or alleviate the water blocking effect (WBE) encountered while hydraulic fracturing of coal seams, the wettability of the coal body was changed, using gas-wetting reversal technology, thus improving gas drainage.	Water	30-35	gastrin	Homo sapiens	164-167
9365262-1	1997	We present a comparative analysis of the water organization around the dTn.dAn x dTn triple helix and the Watson-Crick double helix dTn.dAn respectively by means of gravimetric measurements, infrared spectroscopy and molecular dynamics simulations.	Water	41-46	distal antenna	Drosophila melanogaster	75-78
32810620-0	2020	Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-kappaB and TGF-beta/smads signaling pathways.	Water	20-25	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	69-74
33184209-0	2020	Hydrogen escape from Mars is driven by seasonal and dust storm transport of water.	Water	76-81	methionyl-tRNA synthetase 1	Homo sapiens	21-25
33184209-1	2020	Mars has lost most of its once-abundant water to space, leaving the planet cold and dry.	Water	40-45	methionyl-tRNA synthetase 1	Homo sapiens	0-4
32699966-4	2020	Besides, CDC1 and CDC2 can detect HSO3- in pure water and detection limits of CDC1 and CDC2 reached 4.59 nM and 8.19 nM, respectively.	Water	48-53	cyclin dependent kinase 1	Homo sapiens	18-22
32699966-4	2020	Besides, CDC1 and CDC2 can detect HSO3- in pure water and detection limits of CDC1 and CDC2 reached 4.59 nM and 8.19 nM, respectively.	Water	48-53	cyclin dependent kinase 1	Homo sapiens	87-91
32645571-1	2020	Two-stage pilot-scale partial nitrification (PN)-anammox reactors were successfully operated for the treatment of reject-water (record as TRW) produced from the anaerobic digestion of thermal hydrolysis-treated sludge (THPAD).	Water	121-126	tRNA tryptophan	Homo sapiens	138-141
33184209-3	2020	Using observations from the Neutral Gas and Ion Mass Spectrometer on the Mars Atmosphere and Volatile Evolution spacecraft, we demonstrate that water is instead transported directly to the upper atmosphere, then dissociated by ions to produce atomic hydrogen.	Water	144-149	methionyl-tRNA synthetase 1	Homo sapiens	73-77
33184209-5	2020	We calculate that this transport of water dominates the present-day loss of atomic hydrogen to space and influenced the evolution of Mars" climate.	Water	36-41	methionyl-tRNA synthetase 1	Homo sapiens	133-137
9365262-1	1997	We present a comparative analysis of the water organization around the dTn.dAn x dTn triple helix and the Watson-Crick double helix dTn.dAn respectively by means of gravimetric measurements, infrared spectroscopy and molecular dynamics simulations.	Water	41-46	distal antenna	Drosophila melanogaster	136-139
9374809-3	1997	Blockade of AT1 receptors with valsartan increased slightly sodium and water excretion at low renal perfusion pressure (RPP).	Water	71-76	angiotensin II receptor, type 1a	Rattus norvegicus	12-15
33136401-7	2020	However, we observed glutamate 459 being utilized as a proton abstractor to prime the attacking water instead of a lytic water, a phenomenon not well categorized in myosin but has in other ATPases.	Water	96-101	myosin heavy chain 14	Homo sapiens	165-171
33136401-7	2020	However, we observed glutamate 459 being utilized as a proton abstractor to prime the attacking water instead of a lytic water, a phenomenon not well categorized in myosin but has in other ATPases.	Water	121-126	myosin heavy chain 14	Homo sapiens	165-171
32631905-5	2020	The gene hub Aquaporin-7 (AQP7), a water and glycerol channel, was identified as a novel regulator of breast cancer.	Water	35-40	aquaporin 7	Mus musculus	13-24
32631905-5	2020	The gene hub Aquaporin-7 (AQP7), a water and glycerol channel, was identified as a novel regulator of breast cancer.	Water	35-40	aquaporin 7	Mus musculus	26-30
33350272-9	2020	The water extract of LFH can significantly reduce the content of inflammatory factors in rats with ALI, and down-regulate the mRNA expression of TNFAIP3, IL1 R1, IL6 R and NFKBIA in the lung tissues, showing significant anti-inflammatory effect.	Water	4-9	TNF alpha induced protein 3	Rattus norvegicus	145-152
33350272-9	2020	The water extract of LFH can significantly reduce the content of inflammatory factors in rats with ALI, and down-regulate the mRNA expression of TNFAIP3, IL1 R1, IL6 R and NFKBIA in the lung tissues, showing significant anti-inflammatory effect.	Water	4-9	NFKB inhibitor alpha	Rattus norvegicus	172-178
9406861-6	1997	The addition of 2 mM Co(II) in the drinking water reduced the glycemia of streptozotocin-induced diabetic rats by day 3 from 32.3 +/- 2.1 to 21.0 +/- 1.9 mM (non-fasting).	Water	44-49	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	21-27
33027427-5	2020	RESULTS: Caries prevalence was 71.7%, and was higher in females (PR=1.09 - 95%CI 1.04;1.15), associated with being behind at school (PR=1.11 - 95%CI 1.03;1.18), dental calculus (PR=1.10 - 95%CI 1.01;1.20) and no access to fluoridated water (PR=1.21 - 95%CI 1.01;1.45).	Water	234-239	transmembrane protein 37	Homo sapiens	133-135
33027427-5	2020	RESULTS: Caries prevalence was 71.7%, and was higher in females (PR=1.09 - 95%CI 1.04;1.15), associated with being behind at school (PR=1.11 - 95%CI 1.03;1.18), dental calculus (PR=1.10 - 95%CI 1.01;1.20) and no access to fluoridated water (PR=1.21 - 95%CI 1.01;1.45).	Water	234-239	transmembrane protein 37	Homo sapiens	133-135
33027427-5	2020	RESULTS: Caries prevalence was 71.7%, and was higher in females (PR=1.09 - 95%CI 1.04;1.15), associated with being behind at school (PR=1.11 - 95%CI 1.03;1.18), dental calculus (PR=1.10 - 95%CI 1.01;1.20) and no access to fluoridated water (PR=1.21 - 95%CI 1.01;1.45).	Water	234-239	transmembrane protein 37	Homo sapiens	133-135
33190991-7	2021	RESULTS: BCM yielded the following equation: ASM (kg) = -1.838 + 0.395 x total body water (L) + 0.105 x body weight (kg) + 1.231 x male sex - 0.026 x age (years) (R2 = 0.914, standard error of estimate = 1.35 kg).	Water	84-89	H19 imprinted maternally expressed transcript	Homo sapiens	45-48
9299539-6	1997	The MBP obtained was readily soluble in water and possessed the capacity to induce experimental autoimmune encephalomyelitis in susceptible mice.	Water	40-45	myelin basic protein	Mus musculus	4-7
32822993-8	2020	The linear response for the analytes was in the range of 0.18-100.0 ng mL-1 for water samples and 0.9-100.0 ng mL-1 for honey-pomelo beverage samples.	Water	80-85	L1 cell adhesion molecule	Mus musculus	71-75
32822999-7	2020	The relative recoveries of the analytes for the six environmental water samples at the spiked concentrations of 0.2, 0.5, 3.0 and 30.0 ng mL-1 were between 83.6% and 118% with the relative standard deviations ranging from 2.4% to 11.3%.	Water	66-71	L1 cell adhesion molecule	Mus musculus	138-142
32924547-4	2020	AVP facilitates reabsorption of water through increased abundance and insertion of AQP2 in the apical membrane of the principal cells in the collecting ducts.	Water	32-37	aquaporin 2	Homo sapiens	83-87
9315283-4	1997	In water-deprived rat kidneys, the steady-state levels of p38 MAP kinase mRNA increased about 2.7-fold as compared with those of control rats.	Water	3-8	mitogen activated protein kinase 14	Rattus norvegicus	58-72
33017189-1	2020	Vasopressin regulates osmotic water transport in the renal collecting duct by protein kinase A (PKA)-mediated control of the water channel aquaporin-2 (AQP2).	Water	30-35	aquaporin 2	Mus musculus	152-156
33061976-7	2020	The corrosion tests reveal that the peak-aged composite corrodes more in Red Sea water when compared to that of other groups of specimens.	Water	81-86	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	77-80
33017189-1	2020	Vasopressin regulates osmotic water transport in the renal collecting duct by protein kinase A (PKA)-mediated control of the water channel aquaporin-2 (AQP2).	Water	125-130	aquaporin 2	Mus musculus	152-156
9292489-1	1997	Recent evidence suggests that water transport between the pulmonary vasculature and air spaces can be inhibited by HgCl2, an agent that inhibits water channels (aquaporin-1 and -5) of cell membranes.	Water	30-35	aquaporin 1	Rattus norvegicus	161-179
32880425-2	2020	Herein, the excited-state proton transfer (ESPT) concept-based luminescent sensor [Cd2(2,5-tpt)(4,5-idc)(H2O)4] (1) (2,5-tpt = 2,5-dihydroxyterephthalic acid and 4,5-idc = 4,5-imidazoledicarboxylic acid) has been designed for discriminative detection via enol-keto tautomerism.	Water	105-108	CD2 molecule	Homo sapiens	83-86
32679115-6	2020	Silencing of RGS2 or Forskolin (activator of cAMP pathway) developed sweet water consumption, reduced inflammation and oxidative stress injury, and attenuated cognitive impairment and neuronal damage in mice with depression-like behaviors.	Water	75-80	regulator of G-protein signaling 2	Mus musculus	13-17
9309208-0	1997	Comparison of the water transporting properties of MIP and AQP1.	Water	18-23	major intrinsic protein of lens fiber L homeolog	Xenopus laevis	51-54
33015467-1	2020	Excessive water production from natural gas reservoirs is a main challenge facing the industry nowadays.	Water	10-15	gastrin	Homo sapiens	40-43
32720054-5	2020	A combined ANOVA (analysis of variance) and HCA (hierarchical clustering analysis) showed that hsp70 silencing led to severe growth retardation and mortality, significant membrane damage and leakage, decline in relative water content, low rate of pigment accumulation, and reduced antioxidant enzyme activity under normal and drought stress conditions.	Water	220-225	heat shock protein 70	Solanum lycopersicum	95-100
9309208-1	1997	In this paper we compare the water-transport properties of Aquaporin (AQP1), a known water channel, and those of the 28 kD Major Intrinsic Protein of Lens (MIP), a protein with an undefined physiological role.	Water	29-34	major intrinsic protein of lens fiber L homeolog	Xenopus laevis	156-159
32828321-6	2020	On the other hand, mice fed with DMB drinking water showed lower TMAO level, interleukin (IL)-1beta and IL-6, and higher vascular endothelial growth factor in the ischemic muscle, and better perfusion recovery after experimental PAD.	Water	46-51	interleukin 1 alpha	Mus musculus	77-99
9309208-7	1997	Water transport by MIP had a higher activation energy (approximately 7 Kcal/ mole) than water transport by AQP1 (approximately 2.5 Kcal/Mole) but a substantially lower activation energy than water flux across bare oolemma (approximately 20 Kcal/mole).	Water	0-5	major intrinsic protein of lens fiber L homeolog	Xenopus laevis	19-22
9309208-8	1997	Though the water-transport properties of MIP and AQP1 differ quantitatively, they are qualitatively quite similar.	Water	11-16	major intrinsic protein of lens fiber L homeolog	Xenopus laevis	41-44
9309208-10	1997	Thus water transport in the lens seems a plausible physiological role for MIP.	Water	5-10	major intrinsic protein of lens fiber L homeolog	Xenopus laevis	74-77
33013800-1	2020	Unconventional oil and gas exploration generates an enormous quantity of wastewater, commonly referred to as flowback and produced water (FPW).	Water	78-83	gastrin	Homo sapiens	23-26
32705557-0	2020	Water quality assessment and pollution source apportionment using multi-statistic and APCS-MLR modeling techniques in Min River Basin, China.	Water	0-5	amyloid P component, serum	Homo sapiens	86-90
9214296-1	1997	Large enhancements (maximum of 82-fold in terms of enzyme efficiency, Vmax/Km) of bacterial PI-PLC cyclic phosphodiesterase activity were observed in the presence of organic solvents miscible in water (dimethyl sulfoxide, dimethylformamide, and 2-propanol).	Water	195-200	phospholipase C beta 1	Homo sapiens	92-98
32781123-6	2020	Driven solely by gravity, the separation flux of the cellulose nanofibers for mixture of oil and water reaches 34,300.6 L m-2 h-1, and the separation flux and efficiency for surfactant-stabilized emulsion of oil and water reach 2503.7 L m-2 h-1 and over 98.3%, respectively.	Water	97-102	H1.5 linker histone, cluster member	Homo sapiens	126-129
32899395-5	2020	In this work S29 was stably conjugated with highly water-dispersible GO nanoparticles.	Water	51-56	ribosomal protein S29	Homo sapiens	13-16
9249549-3	1997	Intracerebroventricular infusion, over 1-3 h, of the ANG II type 1 (AT1) receptor antagonist, losartan, decreased or abolished water intake caused by all of the stimuli tested.	Water	127-132	type-1 angiotensin II receptor	Ovis aries	68-71
31818185-10	2020	CASP9 expression or exogenously added H2O2 in the CASP9 KO cells corrected the ATG3 level and lipidation status of Atg8-family members, and restored autophagy flux.	Water	38-42	caspase 9	Homo sapiens	50-55
32529500-1	2020	BACKGROUND: Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct.	Water	40-45	aquaporin 2	Homo sapiens	12-23
9249549-4	1997	Intracerebroventricular infusion of ZD-7155, another AT1-receptor antagonist, blocked ANG II-induced water intake.	Water	101-106	type-1 angiotensin II receptor	Ovis aries	53-56
32529500-1	2020	BACKGROUND: Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct.	Water	40-45	aquaporin 2	Homo sapiens	25-29
32064985-7	2020	Moreover, the addition of AG490, the protein inhibitor of JAK2, significantly alleviated cerebral ischemic damage in vivo and H2O2-induced injury in vitro, and JAK2 siRNA also alleviated H2O2-induced injury in N2a cell.	Water	126-130	Janus kinase 2	Mus musculus	58-62
32529500-1	2020	BACKGROUND: Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct.	Water	83-88	aquaporin 2	Homo sapiens	12-23
9252492-0	1997	Water deprivation upregulates ANG II AT1 binding and mRNA in rat subfornical organ and anterior pituitary.	Water	0-5	angiotensin II receptor, type 1a	Rattus norvegicus	37-40
32529500-1	2020	BACKGROUND: Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct.	Water	83-88	aquaporin 2	Homo sapiens	25-29
32064985-7	2020	Moreover, the addition of AG490, the protein inhibitor of JAK2, significantly alleviated cerebral ischemic damage in vivo and H2O2-induced injury in vitro, and JAK2 siRNA also alleviated H2O2-induced injury in N2a cell.	Water	187-191	Janus kinase 2	Mus musculus	58-62
32064985-7	2020	Moreover, the addition of AG490, the protein inhibitor of JAK2, significantly alleviated cerebral ischemic damage in vivo and H2O2-induced injury in vitro, and JAK2 siRNA also alleviated H2O2-induced injury in N2a cell.	Water	187-191	Janus kinase 2	Mus musculus	160-164
9201966-0	1997	Adsorption of pulmonary surfactant protein D to phospholipid monolayers at the air-water interface.	Water	83-88	surfactant protein D	Rattus norvegicus	14-44
32771852-8	2020	The energy and water consumption for the best alternative (ethanol-water ratio 1/1 including recycle stream, named E-W 1/1 Rec) were 567 MJ/h and 105 kg/h, respectively and the CO2 emission was 105 kg/h.	Water	67-72	RBPJ pseudogene 4	Homo sapiens	123-126
32687659-1	2020	The endothelin receptor type B (ETBR) regulates water and electrolyte balance and blood pressure, in part, by inhibiting renal sodium transport.	Water	48-53	endothelin receptor type B	Mus musculus	4-30
32687659-1	2020	The endothelin receptor type B (ETBR) regulates water and electrolyte balance and blood pressure, in part, by inhibiting renal sodium transport.	Water	48-53	endothelin receptor type B	Mus musculus	32-36
32794154-3	2020	Aquaporin-4 (AQP4), the principal astrocyte water channel, is primarily involved in brain edema development.	Water	44-49	aquaporin 4	Rattus norvegicus	0-11
9201966-2	1997	The interactions of recombinant SP-D with monolayers of phosphatidylcholine (PC), phosphatidylglycerol (PG), and phosphatidylinositol (PI) spread at the air-water interface have been characterized.	Water	157-162	surfactant protein D	Rattus norvegicus	32-36
32794154-3	2020	Aquaporin-4 (AQP4), the principal astrocyte water channel, is primarily involved in brain edema development.	Water	44-49	aquaporin 4	Rattus norvegicus	13-17
32993994-0	2020	Pen sensor made with silver nanoparticles decorating graphite-polyurethane electrodes to detect bisphenol-A in tap and river water samples.	Water	125-130	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	0-3
32993994-6	2020	The PEN Sensor could also detect bisphenol-A in tap and river water samples, with satisfactory reproducibility and repeatability, while common interferents did not affect electrooxidation of bisphenol-A.	Water	62-67	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	4-7
9219154-5	1997	In a separate group of rats, ETA receptor blockade was verified after 3 d of drinking water containing A-127722.	Water	86-91	endothelin receptor type A	Rattus norvegicus	29-32
32853485-9	2020	The ROCK2, PMVK, ADCY2, MAP2K6, BMP10 and GFPT1 genes are main candidates for reproductive traits in water dairy buffaloes and, these results may have future applications in animal breeding programs or in gene expression studies of the species.	Water	101-106	rho-associated protein kinase 2	Bubalus bubalis	4-9
32856135-5	2020	Under the optimized condition, the method provided good linearity ranging from 0.3 to 100.0 ng mL-1 with low limits of detection of 0.10-0.20 ng mL-1 for grape juice, 0.10-0.30 ng mL-1 for blend fruit juice, and 0.10-0.20 ng mL-1 for water sample.	Water	234-239	L1 cell adhesion molecule	Mus musculus	95-99
9154857-6	1997	Mean Sniff Pdi in the elderly was 119 cm H2O compared with 136 cm H2O for the young subjects; this represented a median reduction of 18 cm H2O or 13% (p = 0.05, 95% Cl of difference 0 to 33 cm H2O).	Water	41-44	prolyl 4-hydroxylase subunit beta	Homo sapiens	11-14
32856135-5	2020	Under the optimized condition, the method provided good linearity ranging from 0.3 to 100.0 ng mL-1 with low limits of detection of 0.10-0.20 ng mL-1 for grape juice, 0.10-0.30 ng mL-1 for blend fruit juice, and 0.10-0.20 ng mL-1 for water sample.	Water	234-239	L1 cell adhesion molecule	Mus musculus	145-149
32856135-5	2020	Under the optimized condition, the method provided good linearity ranging from 0.3 to 100.0 ng mL-1 with low limits of detection of 0.10-0.20 ng mL-1 for grape juice, 0.10-0.30 ng mL-1 for blend fruit juice, and 0.10-0.20 ng mL-1 for water sample.	Water	234-239	L1 cell adhesion molecule	Mus musculus	145-149
32856135-5	2020	Under the optimized condition, the method provided good linearity ranging from 0.3 to 100.0 ng mL-1 with low limits of detection of 0.10-0.20 ng mL-1 for grape juice, 0.10-0.30 ng mL-1 for blend fruit juice, and 0.10-0.20 ng mL-1 for water sample.	Water	234-239	L1 cell adhesion molecule	Mus musculus	145-149
33121486-5	2020	Using an unbiased analysis of gene expression in the dorsal hippocampus after training in the Morris water maze or contextual fear conditioning, we discovered dysregulation of CREB, CLOCK, and BMAL1 target genes and downregulation of circadian genes in CBPKIX/KIX mice.	Water	101-106	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	193-198
33078936-7	2020	This experiment shows that the V+ + H2O reaction can be controlled effectively to produce predominantly the VO+ + H2 channel via the V+(a3FJ) + H2O reaction at low Ecm"s (<=0.1 eV) and that the ion-molecule reaction dynamics can be altered readily by selecting the electronic state of V+ cation.	Water	144-147	multimerin 1	Homo sapiens	164-167
32854399-4	2020	More importantly, we used it as a SERS substrate to detect cadmium ions and found that its limit of detection (LOD) reaches up to 2.6 x 10-8 M, which is lower than the highest allowable Cd2+ concentration in drinking water set by the World Health Organization (WHO) and Environmental Protection Agency (EPA).	Water	217-222	CD2 molecule	Homo sapiens	186-189
32854399-5	2020	Therefore, the proposed composite can be applicable to the detection of Cd2+ in drinking water and in soil.	Water	89-94	CD2 molecule	Homo sapiens	72-75
9154857-7	1997	Mean Twitch Pdi in the elderly was 26.8 cm H2O compared with 35.2 cm H2O, a median reduction of 8 cm H2O or 23% (p = 0.004, 95% Cl 3 to 13 cm H2O).	Water	43-46	prolyl 4-hydroxylase subunit beta	Homo sapiens	12-15
9113262-1	1997	In previous studies, we found that single injections of the thyrotropin-releasing hormone analog TA-0910 dose-dependently reduced alcohol intake and preference in alcohol-preferring (P) and Fawn-Hooded (FH) rats over a 24-hr period of continuous access to alcohol and water.	Water	268-273	thyrotropin releasing hormone	Rattus norvegicus	60-89
32673565-6	2020	In vivo, IL-24 treatment ameliorated Th17-induced EAU, whereas silencing of IL-24 in Th17 cells enhanced disease.	Water	50-53	interleukin 24	Homo sapiens	9-14
32330808-4	2020	Subsequently, sensitive, selective, and differential detections for Cu2+ (LOD: 0.080 muM) and Pd2+ (LOD: 0.076 muM) in 100% aqueous solutions were achieved, which proved to be applicable for real water samples.	Water	196-201	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	94-97
32375070-1	2020	The Arabian Sea, one of the most biologically productive oceanic regions, receive significant amount of nutrients through aeolian dust deposition which have potential to modulate surface water biogeochemical processes.	Water	187-192	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	12-15
32567615-1	2020	Gas hydrates have received considerable attention due to their important role in flow assurance for the oil and gas industry, their extensive natural occurrence on Earth and extraterrestrial planets, and their significant applications in sustainable technologies including but not limited to gas and energy storage, gas separation, and water desalination.	Water	336-341	gastrin	Homo sapiens	0-3
32638584-3	2020	We demonstrate a non-destructive modified gas-phase technique with co-deposition of both precursors trimethylaluminum (TMA) and water, to dramatically enhance the PL emission in zero-dimensional (0D) Cs4PbBr6 PNCs via alumina encapsulation.	Water	128-133	gastrin	Homo sapiens	42-45
33070855-8	2020	The modified electrode was used for Cd2+ and Pb2+ analysis in real water samples with satisfactory results.	Water	67-72	CD2 molecule	Homo sapiens	36-39
33195109-2	2020	In this work, V-doped CoP nanosheet arrays supported on the carbon cloth (V-CoP/CC) are fabricated though a facile water-bath/phosphorization method.	Water	115-120	caspase recruitment domain family member 16	Homo sapiens	22-25
33114244-0	2020	Long-Term Persistence of blaCTX-M-15 in Soil and Lettuce after Introducing Extended-Spectrum beta-Lactamase (ESBL)-Producing Escherichia coli via Manure or Water.	Water	156-161	beta-lactamase	Escherichia coli	25-36
33114244-6	2020	In contrast, qPCR detection of blaCTX-M-15 was much more frequent: introduction via water significantly increased blaCTX-M-15 on lettuce until week 4, as opposed to manure, which affected the soil in the long-term (9 weeks) while leading to blaCTX-M-15 detection on lettuce until day 7 only.	Water	84-89	beta-lactamase	Escherichia coli	31-42
33114244-6	2020	In contrast, qPCR detection of blaCTX-M-15 was much more frequent: introduction via water significantly increased blaCTX-M-15 on lettuce until week 4, as opposed to manure, which affected the soil in the long-term (9 weeks) while leading to blaCTX-M-15 detection on lettuce until day 7 only.	Water	84-89	beta-lactamase	Escherichia coli	114-125
33114244-6	2020	In contrast, qPCR detection of blaCTX-M-15 was much more frequent: introduction via water significantly increased blaCTX-M-15 on lettuce until week 4, as opposed to manure, which affected the soil in the long-term (9 weeks) while leading to blaCTX-M-15 detection on lettuce until day 7 only.	Water	84-89	beta-lactamase	Escherichia coli	114-125
32535467-3	2020	The aim of this study was to systematically evaluate the surface properties, morphology, structure, composition, as well as aggregation dynamics of S-Ag-NPs in synthetic and natural river water.	Water	188-193	S-antigen visual arrestin	Homo sapiens	148-152
32535467-8	2020	The critical coagulation concentration (CCC) of Ca2+ determined for S-Ag-NPs in reconstituted river water was 2.47 +- 0.23 mmol/L and thus higher than the CCC obtained for Cit-Ag-NPs in our earlier study revealing higher colloidal stability of S-Ag-NPs.	Water	100-105	S-antigen visual arrestin	Homo sapiens	68-72
32535467-11	2020	For S-Ag-NPs stabilized by a low amount of citrate, we expect longer residence times in the water phase of rivers and thus higher risk for aquatic organisms.	Water	92-97	S-antigen visual arrestin	Homo sapiens	4-8
32544674-10	2020	Species diversity roughly showed a first increasing then decreasing trend with the increase of the water depth in the southern Yellow Sea and East China Sea.	Water	99-104	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	134-137
32544674-10	2020	Species diversity roughly showed a first increasing then decreasing trend with the increase of the water depth in the southern Yellow Sea and East China Sea.	Water	99-104	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	153-156
33030091-8	2022	Interestingly, it is found that due to the variable conformations of the SF region as wide/narrow, the effect of the NDI causing mutants on the average water permeability can be revealed with notably better accuracy by finding the wide states in the wild-type and mutated types of AQP2 and comparing the osmotic permeabilities for this state.	Water	152-157	aquaporin 2	Homo sapiens	281-285
32852952-4	2020	Gas-phase ion-molecule reactions of trimethoxymethylsilane (TMMS) were used to identify the protonation sites of 4-aminobenzoic acid ionized using APCI with methanol or acetonitrile-water as the solvent.	Water	182-187	gastrin	Homo sapiens	0-3
32755465-6	2020	The data demonstrate that treatment of larvae with acidic water for 4 days postfertilization caused cell-specific increases in H+-ATPase (atp6v1aa), ca17a, ca15a, nhe3b, and rhcgb mRNA in addition to increases in mRNA linked to cell proliferation.	Water	58-63	carbonic anhydrase XVa	Danio rerio	156-161
32755465-6	2020	The data demonstrate that treatment of larvae with acidic water for 4 days postfertilization caused cell-specific increases in H+-ATPase (atp6v1aa), ca17a, ca15a, nhe3b, and rhcgb mRNA in addition to increases in mRNA linked to cell proliferation.	Water	58-63	Rh family, C glycoprotein b	Danio rerio	174-179
32657925-6	2020	There was significantly increased likelihood of SLN identification with injection dose >=1 mg compared to <1 mg (65.2% vs 35.0%, P = 0.05), lung ventilation after injection (65.2% vs 35.0%, P = 0.05), and albumin dissolvent (68.1%) compared to fresh frozen plasma (28.6%) and sterile water (20.0%) (P = 0.01).	Water	284-289	sarcolipin	Homo sapiens	48-51
32717630-3	2020	RBp was prepared by 80 % ethanol precipitation of the water extract of Rhizoma Bletillae followed by the Sevag method to remove proteins.	Water	54-59	retinol binding protein 4	Rattus norvegicus	0-3
32707194-6	2020	FINDINGS: OXA-48 producing K. pneumoniae was detected in toilet water in 4/6 rooms and drain water between two rooms.	Water	64-69	OXA-48	Klebsiella pneumoniae	10-16
32129568-0	2020	Maize WI5 encodes an endo-1,4-beta-xylanase required for secondary cell wall synthesis and water transport in xylem.	Water	91-96	endosperm specific protein 1	Zea mays	21-27
32706443-1	2020	KEY POINTS: Neuronal activity causes astrocytic volume change via K+ uptake through TREK-1 containing two-pore domain potassium channels The volume transient is terminated by Cl- efflux through Ca2+-activated anion channel, BEST1 The source of Ca2+ to open BEST1 appears to be the stretch-activated TRPA1 channel Intense neuronal activity is synaptically coupled with a physical change in astrocytes via volume transients ABSTRACT: The brain volume changes dynamically and transiently upon intense neuronal activity through a tight regulation of ion concentrations and water movement across the plasma membrane of astrocytes.	Water	569-574	potassium channel, subfamily K, member 2	Mus musculus	84-90
33077138-2	2020	AQP1, AQP3 and AQP5 are isoforms of aquaporin known to aid in transepithelial water movement.	Water	78-83	aquaporin 3 (Gill blood group)	Homo sapiens	6-10
33077138-2	2020	AQP1, AQP3 and AQP5 are isoforms of aquaporin known to aid in transepithelial water movement.	Water	78-83	aquaporin 5	Homo sapiens	15-19
32993088-3	2020	The principal cell-specific water channel aquaporin-2 (AQP2) plays an essential role in water reabsorption along osmotic gradients.	Water	28-33	aquaporin 2	Homo sapiens	55-59
33005188-0	2020	Evaluation of Geophagy Clay Capacity in Adsorbing Cd2+ and Pb2+ for Water Treatment in Southeast Nigeria.	Water	68-73	CD2 molecule	Homo sapiens	50-53
33005188-2	2020	This study determines elemental concentration of geophagy clay and evaluates its adsorptive capacity in removing Cd2+ and Pb2+ in water.	Water	130-135	CD2 molecule	Homo sapiens	113-116
33005188-9	2020	The study, therefore, concluded that geophagy clay possesses the capacity to adsorb Cd2+ and Pb2+ for water treatment.	Water	102-107	CD2 molecule	Homo sapiens	84-87
32932764-1	2020	[D-Leu1]MC-LR and MC-LR, two microcystins differing in one amino acid, constitute a sanitary and environmental problem owing to their frequent and concomitant presence in water bodies of the Americas and their association with human intoxication during recreational exposure to cyanobacterial bloom.	Water	171-176	deleted in lymphocytic leukemia 1	Homo sapiens	3-7
32984695-0	2020	Two-Dimensional CdX/C2N (X = S, Se) Heterostructures as Potential Photocatalysts for Water Splitting: A DFT Study.	Water	85-90	squalene epoxidase	Homo sapiens	32-34
32984695-2	2020	The photocatalytic water splitting activities of CdX/C2N (X = S, Se) heterostructures have been investigated here using hybrid density functional theory calculations.	Water	19-24	squalene epoxidase	Homo sapiens	65-67
31744994-8	2020	Administration of H2O2 stimulated the overexpression of PK2 in GC-2.	Water	18-22	prokineticin 2	Rattus norvegicus	56-59
32515831-4	2020	Under experimental conditions, beta-casein forms micellar structures in which the hydrophilic part of the protein is water accessible and able to interact with 1.	Water	117-122	casein beta	Homo sapiens	31-42
32634698-8	2020	Elevated miR-27a or reduced HSP90 diminished water content, neuronal apoptosis and infarct volume, suppressed oxidative stress and inflammatory response, as well as improved neurological deficits and pathological damages.	Water	45-50	microRNA 27a	Rattus norvegicus	9-16
32445838-7	2020	Low IgG Fc sialylation programming in GC B cells was overall highly dependent on the T follicular helper (TFH) cell-inducing cytokine IL-6, especially induced by water-in-oil adjuvants and Mycobacterium tuberculosis (Mtb).	Water	162-167	natriuretic peptide receptor 2	Mus musculus	38-42
9095083-6	1997	The renal cytolocalization of the Ang II/AVP receptor to the outer medullary thick ascending limb tubules and inner medullary collecting ducts is consistent with the well-established AVP stimulation of sodium and water reabsorption in these tubules.	Water	213-218	angiogenin	Homo sapiens	34-37
9176054-9	1997	In the lens, the major water channel is AQP1 with detectable levels of AQP4 and AQP5 that are approximately 1000-fold lower than AQP1.	Water	23-28	aquaporin 1	Rattus norvegicus	40-44
32945844-2	2020	We have mapped the subcellular distribution of the lens aquaporins (AQP0, AQP1, and AQP5) in these water influx and efflux zones and investigated how their membrane location is affected by changes in tension applied to the lens by the zonules.	Water	99-104	major intrinsic protein of lens fiber	Rattus norvegicus	68-72
32649828-3	2020	Due to the ultra-thin nature and ordered pores, the membrane exhibited an ultra-high permeance (water ~ 411 L m-2 h-1 bar-1 and acetonitrile ~ 583 L m-2 h-1 bar-1) and excellent rejection of dye molecules larger than 1.4 nm (> 98%).	Water	96-101	H1.5 linker histone, cluster member	Homo sapiens	114-117
33241402-1	2020	BACKGROUND: A simple, rapid, selective and sensitive sample preparation and derivatization method was performed for determination of bromate ions in water by means of dispersive liquid-liquid extraction (DLLE) by gas chromatography-electron capture detection (GC-ECD).	Water	149-154	gastrin	Homo sapiens	213-216
32618565-2	2020	Lithium concentrates into principal cells in collecting ducts in the kidney and downregulates aquaporin 2 expression, which reduces renal reabsorption of water.	Water	154-159	aquaporin 2	Homo sapiens	94-105
9176054-9	1997	In the lens, the major water channel is AQP1 with detectable levels of AQP4 and AQP5 that are approximately 1000-fold lower than AQP1.	Water	23-28	aquaporin 1	Rattus norvegicus	129-133
9176054-10	1997	In choroid, AQP1 is the only water channel expressed.	Water	29-34	aquaporin 1	Rattus norvegicus	12-16
26735441-1	1997	We have studied the activities of the GABA metabolizing enzymes-GABA aminotransferase (GABA-AT), succinic semialdehyde dehydrogenase (SSA-DH) and SSA reductase (SSA-R) and the levels of GABA, glutamine and glutamate in rats preferring water (WP) or ethanol (EP) after 6 months of ethanol consumption and 12 hours to 7 days after withdrawal.	Water	235-240	aldo-keto reductase family 7, member A2	Rattus norvegicus	161-166
31599965-7	2020	However, there was an increased incidence of AE in infants with FLG mutations exposed to hard water (adjusted HR 2 72, 95% CI 2 03-3 66), and statistically significant interactions between hard water plus FLG and both risk of AE (HR 1 80, 95% CI 1 17-2 78) and transepidermal water loss (0 0081 g m-2 h-1 per mg L-1 CaCO3 , 95% CI 0 00028-0 016).	Water	94-99	filaggrin	Homo sapiens	64-67
31599965-8	2020	CONCLUSIONS: There is evidence of an interaction between water hardness and FLG mutations in the development of infantile AE.	Water	57-62	filaggrin	Homo sapiens	76-79
32687683-2	2020	Herein, an inorganic nanocomposite material Ag2 S@ZnS was prepared and used as a coating for fibers to detect polycyclic aromatic hydrocarbons in water samples in combination with a GC with flame ionization detector.	Water	146-151	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	44-47
32446035-0	2020	Contrast-enhanced magnetic resonance imaging evidence for the role of astrocytic aquaporin-4 water channels in glymphatic influx and interstitial solute transport.	Water	93-98	aquaporin 4	Rattus norvegicus	81-92
32446035-1	2020	The present study aimed to confirm the hypothesis that aquaporin-4 water channels (AQP4) control solute transition into the brain parenchyma using image analysis of gadolinium-based contrast agents (GBCAs) dissolved in cerebrospinal fluid (CSF) on dynamic contrast-enhanced magnetic resonance imaging (dyMRI) in live rats.	Water	67-72	aquaporin 4	Rattus norvegicus	55-66
32446035-1	2020	The present study aimed to confirm the hypothesis that aquaporin-4 water channels (AQP4) control solute transition into the brain parenchyma using image analysis of gadolinium-based contrast agents (GBCAs) dissolved in cerebrospinal fluid (CSF) on dynamic contrast-enhanced magnetic resonance imaging (dyMRI) in live rats.	Water	67-72	aquaporin 4	Rattus norvegicus	83-87
32302913-1	2020	A novel n-n type inorganic/organic heterojunction of flaky-like BiOCl/PDI photocatalyst was constructed by water bath heating method.	Water	107-112	peptidyl arginine deiminase 1	Homo sapiens	70-73
9118459-5	1997	Against the same tumor model, using the same treatment schedule, each of the water-soluble derivatives was active, with maximum LCK of 1.3-2.5 and T/C of 124-254%.	Water	77-82	lymphocyte protein tyrosine kinase	Mus musculus	128-131
32213363-0	2020	Emerging and legacy per- and polyfluoroalkyl substances in water, sediment, and air of the Bohai Sea and its surrounding rivers.	Water	59-64	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	97-100
9118459-8	1997	treatment schedules, the water-soluble derivatives achieved a maximum LCK of 1.4-3.8.	Water	25-30	lymphocyte protein tyrosine kinase	Mus musculus	70-73
33164378-3	2020	The concentration-time curve mathematical model of the drug in the unstirred water layer(the adjacent region of alpha-glucosidase) established previously by our group was used to evaluate the concentration-time curves of the tea polyphenols in the alpha-glucosidase vicinity.	Water	77-82	sucrase-isomaltase	Homo sapiens	112-129
9039534-1	1997	The in vitro and in vivo activity of SPA-S-753 (N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate), a new water soluble polyene, was compared with amphotericin B against Cryptococcus neoformans in encapsulated (K) and nonencapsulated (N) morphological forms.	Water	128-133	surfactant associated protein A1	Mus musculus	37-40
33164378-3	2020	The concentration-time curve mathematical model of the drug in the unstirred water layer(the adjacent region of alpha-glucosidase) established previously by our group was used to evaluate the concentration-time curves of the tea polyphenols in the alpha-glucosidase vicinity.	Water	77-82	sucrase-isomaltase	Homo sapiens	248-265
31446599-5	2020	The results revealed that the triple layer membrane with the proportion of 60/40 (Nylon/PEG) has optimal pure water flux and higher filtration efficiency than the other prepared triple layer membranes.	Water	110-115	progestagen associated endometrial protein	Homo sapiens	88-91
8884932-0	1996	The effect of adrenocorticotrophic hormone on water intake in mice.	Water	46-51	pro-opiomelanocortin-alpha	Mus musculus	14-42
32380020-2	2020	Sulfonylurea receptor 1 (SUR1) is an inducible protein that can form a heteromultimeric complex with aquaporin 4 (AQP4) that mediate the ion/water transport involved in brain tissue swelling.	Water	141-146	aquaporin 4	Rattus norvegicus	101-112
32380020-2	2020	Sulfonylurea receptor 1 (SUR1) is an inducible protein that can form a heteromultimeric complex with aquaporin 4 (AQP4) that mediate the ion/water transport involved in brain tissue swelling.	Water	141-146	aquaporin 4	Rattus norvegicus	114-118
32761024-7	2020	We found that a proper choice of hydration algorithms and setups is needed to predict functionally important water molecules in the chromophore-binding cavity of rhodopsins, such as the water cluster in the N-H region of bacteriorhodopsin or two water molecules in the binding pocket of bovine visual rhodopsin.	Water	109-114	rhodopsin	Bos taurus	162-171
32761024-7	2020	We found that a proper choice of hydration algorithms and setups is needed to predict functionally important water molecules in the chromophore-binding cavity of rhodopsins, such as the water cluster in the N-H region of bacteriorhodopsin or two water molecules in the binding pocket of bovine visual rhodopsin.	Water	186-191	rhodopsin	Bos taurus	162-171
32761024-7	2020	We found that a proper choice of hydration algorithms and setups is needed to predict functionally important water molecules in the chromophore-binding cavity of rhodopsins, such as the water cluster in the N-H region of bacteriorhodopsin or two water molecules in the binding pocket of bovine visual rhodopsin.	Water	186-191	rhodopsin	Bos taurus	162-171
8884932-1	1996	The systemic administration of adrenocorticotrophic hormone (ACTH) stimulates the intake of sodium chloride and water in many species.	Water	112-117	pro-opiomelanocortin-alpha	Mus musculus	31-59
8884932-1	1996	The systemic administration of adrenocorticotrophic hormone (ACTH) stimulates the intake of sodium chloride and water in many species.	Water	112-117	pro-opiomelanocortin-alpha	Mus musculus	61-65
32277981-6	2020	The results highlighted the mechanistic aspects by which water soluble globular proteins interact with amphiphilic molecules of different functionalities and thus, helped to predict the interactions of both hemoglobin and myoglobin with the complex biological molecules possessing similar functionalities.	Water	57-62	myoglobin	Homo sapiens	222-231
8884932-7	1996	The results show that a high water intake caused by ACTH administration in mice is not secondary to a concurrent increase in sodium chloride intake.	Water	29-34	pro-opiomelanocortin-alpha	Mus musculus	52-56
32662804-8	2020	To address these limitations, we herein report the development of anionic and water-soluble DSPE-PEG2000 curcumin polymeric micelles (also referred to as curcumin micelles) that can label both brain and retinal Abeta plaques ex vivo.	Water	78-83	amyloid beta (A4) precursor protein	Mus musculus	211-216
8799818-7	1996	Oocytes microinjected with either AQP1 or P25-proteoliposomes exhibited significantly increased osmotic membrane water permeabilities (Pf = 3.16 +/- 026 and 4.03 +/- 0.26 x 10(-3) cm/second, respectively) compared to those measured for oocytes injected with liposomes alone or with MIP26-proteoliposomes (Pf = 1.39 +/- 0.07 and 1.44 +/- 0.10 x 10(-3) cm/second, respectively).	Water	113-118	tubulin polymerization promoting protein	Bos taurus	42-45
32827261-3	2020	Under optimum conditions, the method displayed good linearity (r > 0.9987) within the concentration range 0.05-20 ng mL-1 for water samples and 0.1-40 ng g-1 for tomato samples.	Water	126-131	L1 cell adhesion molecule	Mus musculus	117-121
32860356-1	2020	SIGNIFICANCE: Fluorocoxib D, N-[(rhodamin-X-yl)but-4-yl]-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamide, is a water-soluble optical imaging agent to detect cyclooxygenase-2 (COX-2)-expressing cancer cells.	Water	129-134	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	175-191
32860356-1	2020	SIGNIFICANCE: Fluorocoxib D, N-[(rhodamin-X-yl)but-4-yl]-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamide, is a water-soluble optical imaging agent to detect cyclooxygenase-2 (COX-2)-expressing cancer cells.	Water	129-134	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	193-198
32827261-4	2020	The limits of detection (S/N = 3) for the four carbamate pesticides were in the range 0.0006-0.013 ng mL-1 for water samples and 0.001-0.01 ng g-1 for tomato samples and satisfactory spiked recoveries in the range 86.1 to 109.1% were obtained with the relative standard deviation values from 2.1 to 14.0%.	Water	111-116	L1 cell adhesion molecule	Mus musculus	102-106
8799818-9	1996	Arrhenius activation energies of water transfer were low when AQP1 or P25 were present in oocyte plasma membranes (Ea = 2.29 and 3.01 kcal/mol, respectively, versus Ea = 11.75 kcal/mol for liposome injected oocytes).	Water	33-38	tubulin polymerization promoting protein	Bos taurus	70-73
8882615-11	1996	MAO-A inhibition during HS intake was found to produce a 47-68% decrease in Na+ excretion (from 39.1 +/- 0.7 to 15.1 +/- 2.5 mmol kg-1 day-1, n = 4; P &lt; 0.02) and urine volume (from 160.4 +/- 3.3 to 43.8 +/- 9.0 ml kg-1 day-1, n = 4; P &lt; 0.02) without changes in K+ (from 11.1 +/- 0.5 to 9.2 +/- 0.6 mmol kg-1 day-1, n = 4) and creatinine (from 29.1 +/- 2.3 to 28.4 +/- 2.1 mg kg-1 day-1) excretion; urine osmolality increased 2 fold (from 936.3 +/- 40.3 to 2210.7 +/- 157.4 mOsm kg-1 H2O, n = 4; P &lt; 0.02).	Water	491-494	monoamine oxidase A	Rattus norvegicus	0-5
32905303-5	2020	The mNb-bc was used to catalyze the conversion reaction of xylose into 2-furfuraldehyde in a monophasic system using water as a green solvent.	Water	117-122	NUMB endocytic adaptor protein	Mus musculus	4-7
32796837-2	2020	We find that KIF3A SNP rs11740584 and rs2299007 risk alleles create cytosine-phosphate-guanine sites, which are highly methylated and result in lower KIF3A expression, and this methylation is associated with increased transepidermal water loss (TEWL) in risk allele carriers.	Water	233-238	kinesin family member 3A	Mus musculus	13-18
32645216-8	2020	Additionally, the lyophilized water extract inhibited the in vitro activity of alpha-amylase, alpha-glucosidase, and angiotensin converting enzyme and showed cytotoxic effects towards Caco-2, A549, and HepG2 cancer cells, but no cytotoxicity towards IMR90 cells.	Water	30-35	sucrase-isomaltase	Homo sapiens	94-111
32814886-5	2020	The sum of the contributions to sea-level change from thermal expansion of the ocean, ice-mass loss and changes in terrestrial water storage is consistent with the trends and multidecadal variability in observed sea level on both global and basin scales, which we reconstruct from tide-gauge records.	Water	127-132	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	32-35
32814886-5	2020	The sum of the contributions to sea-level change from thermal expansion of the ocean, ice-mass loss and changes in terrestrial water storage is consistent with the trends and multidecadal variability in observed sea level on both global and basin scales, which we reconstruct from tide-gauge records.	Water	127-132	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	212-215
8606222-0	1996	Water excitation MPRAGE MRI of VII and VIII cranial nerves.	Water	0-5	cytochrome c oxidase subunit 8A	Homo sapiens	39-43
32449227-2	2020	We hypothesized that parasympathetic stimulation with cold-water face immersion following exercise influences QT dynamics in patients with LQTS type 3 (LQT3).	Water	59-64	sodium voltage-gated channel alpha subunit 5	Homo sapiens	152-156
32449227-10	2020	CONCLUSIONS: QT dynamics of LQT3 patients differs from those of other LQTS subtypes during the post-exercise cold-water face immersion test in this study.	Water	114-119	sodium voltage-gated channel alpha subunit 5	Homo sapiens	28-32
32796837-2	2020	We find that KIF3A SNP rs11740584 and rs2299007 risk alleles create cytosine-phosphate-guanine sites, which are highly methylated and result in lower KIF3A expression, and this methylation is associated with increased transepidermal water loss (TEWL) in risk allele carriers.	Water	233-238	kinesin family member 3A	Mus musculus	150-155
32646210-0	2020	In-situ synthesis of SERS active Au@POM nanostructures in a microfluidic device for real time detection of water pollutants.	Water	107-112	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	21-25
8851312-0	1996	[Effects of inhaled anticholinergic agents and beta 2-agonists on distilled water induced cough in patients with chronic cough].	Water	76-81	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	47-53
32770092-4	2020	Despite being charged and soluble, the tau proteins were also highly surface active and favorably interacted with anionic lipid monolayers at the air/water interface.	Water	150-155	microtubule associated protein tau	Homo sapiens	39-42
32770092-5	2020	Membrane binding of tau also led to the formation of a macroscopic, gelatinous layer at the air/water interface, possibly related to tau phase separation.	Water	96-101	microtubule associated protein tau	Homo sapiens	20-23
32602693-5	2020	By adding 30% water to the solvent of ethanol, the activity was increased from 43.2 to 76.8 h-1 and the aniline selectivity was increased from 62.8% to 99.1%.	Water	14-19	H1.5 linker histone, cluster member	Homo sapiens	92-95
32770092-5	2020	Membrane binding of tau also led to the formation of a macroscopic, gelatinous layer at the air/water interface, possibly related to tau phase separation.	Water	96-101	microtubule associated protein tau	Homo sapiens	133-136
8770183-2	1996	Evidence indicates that these proteins show a common structural motif where approximately 50% of the mass is embedded in lipid bilayer (transmembrane domain) in 12 alpha-helices (transmembrane helices; TMHs) and accommodates a water-filled channel for substrate passage (glucose channel) whose tertiary structure is currently unknown.	Water	227-232	LHFPL tetraspan subfamily member 5	Homo sapiens	202-206
32731540-6	2020	Overall, the most active extracts in inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were ethanol/water and ethanol extracts from seeds (between 31.11 and 53.90%).	Water	135-140	butyrylcholinesterase	Homo sapiens	85-106
32731540-6	2020	Overall, the most active extracts in inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were ethanol/water and ethanol extracts from seeds (between 31.11 and 53.90%).	Water	135-140	butyrylcholinesterase	Homo sapiens	108-112
8597423-3	1995	Macrophages are sensitive to stress in that cold-water stress causes increased cytokine production, either spontaneously (IL-1), or after induction with LPS (IL-6, TNF alpha).	Water	49-54	interleukin 1 complex	Mus musculus	122-126
32538409-2	2020	The ability of LHR expressed in CHO cells to initiate signaling in the presence of highly charged and water-soluble polyoxovanadates (POV) including Na3[H3V10O28] (V10) and two mixed-valence heteropolyoxovanadates, K(NH4)4[H6V14O38(PO4)] 11H2O (V14) and [(CH3)4N]6[V15O36(Cl)] (V15), was investigated here.	Water	102-107	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	15-18
32473836-0	2020	Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment.	Water	20-25	glutathione S-transferase pi 1	Homo sapiens	70-77
8599674-3	1995	Measurements by differential scanning calorimetry have shown that this vitreous but freezable water fraction undergoes, on reheating at a rate of 30 K min-1, a glass--&gt;liquid transition with an onset temperature of between approximately 164 and approximately 174 K, with a width of between approximately 9 and approximately 16 degrees and an increase in heat capacity of between approximately 20 and approximately 40 J K-1 (mol of freezable water)-1 but that the glass transition disappears upon crystallization of the freezable water.	Water	94-99	keratin 1	Homo sapiens	422-425
32752278-7	2020	We test here whether CDDP affects ENaC to promote renal salt and water excretion.	Water	65-70	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	34-38
31159053-4	1995	In the second study, tap water (16 C) and ClO2 at a tank concentration of 20 ppm (16 C) were sprayed (690 kPa) for 15, 30, and 60 s onto BCT inoculated with fresh bovine feces to obtain approximately 5.80 log APC/cm2 and the remaining bacterial populations compared.	Water	25-30	tracheal antimicrobial peptide	Bos taurus	21-24
32451894-7	2020	Based on the USSL diagram, the water samples retrieved from the latter system were mostly classified as C3-S1 (decreasing the soil fertility) and even as C4-S2 (harmful for agriculture activities).	Water	31-36	carbohydrate sulfotransferase 12	Homo sapiens	154-159
32585130-13	2020	Water-soluble MMP1 interacting with water-insoluble collagen fibrils poses challenges for biochemical studies that the single-molecule tracking can overcome for other insoluble substrates.	Water	0-5	matrix metallopeptidase 1	Homo sapiens	14-18
32585130-13	2020	Water-soluble MMP1 interacting with water-insoluble collagen fibrils poses challenges for biochemical studies that the single-molecule tracking can overcome for other insoluble substrates.	Water	36-41	matrix metallopeptidase 1	Homo sapiens	14-18
32664335-4	2020	Here, we describe the results of several tests of force fields and water models employed in molecular dynamics simulations for the N-terminal 88 amino acids of c-MYC.	Water	67-72	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	160-165
32650545-0	2020	Potential Metabolite Nymphayol Isolated from Water Lily (Nymphaea stellata) Flower Inhibits MCF-7 Human Breast Cancer Cell Growth via Upregulation of Cdkn2a, pRb2, p53 and Downregulation of PCNA mRNA Expressions.	Water	45-50	proliferating cell nuclear antigen	Homo sapiens	190-194
32306773-7	2020	Drug release modeling suggests that release is driven by rates of water penetration into the SELP nanostructures and drug dissolution.	Water	66-71	selectin P	Homo sapiens	93-97
31159053-6	1995	Similar reductions (1.61 log CFU/cm2) were observed when BCT was spray treated for 60 s with tap water followed by a 60 s spray wash with ClO2.	Water	97-102	tracheal antimicrobial peptide	Bos taurus	93-96
8653552-3	1995	Depletion of neuronal histamine in the hypothalamus induced by alpha-fluoromethylhistidine, a suicide inhibitor of the histamine synthesizing enzyme histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the inhibitory effect on water intake, and enhanced its thermogenic effect.	Water	280-285	histidine decarboxylase	Rattus norvegicus	174-177
32563474-12	2020	Notably, SMD2 presented likewise superior adsorption capacity for CIP with concentrations of 10 and 50 mg/L in Minjiang source water.	Water	127-132	small nuclear ribonucleoprotein D2 polypeptide	Homo sapiens	9-13
32558567-2	2020	A tri(pyridinyl)pyridine viologen-based Kagome dual (kgd) topological coordination polymer, [Mn3Cl4(tpptb)2] Cl2 (H2O)2, (tpptb = N,N",N""-tri(3-carboxybenzyl)-2,4,6-tri(pyridinium-4-yl)pyridine; 1) has been solvothermally synthesized, which can selectively respond to soft X-ray Al-Kalpha (lambda = 8.357 A) irradiation but not to UV light and hard X-rays of lambda < 1.5418 A at room temperature.	Water	114-117	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	2-5
32515970-3	2020	[Ag (PhTSC HCl) 2] (NO3)  H2O (compound 1) was synthesized, characterized, and loaded into polymeric nanoparticles (PN1).	Water	26-29	serpin family E member 2	Homo sapiens	116-119
8770285-1	1995	This study proposes a new solution for the quantification of rCBF pixel-by-pixel using PET and 15O-H2O.	Water	99-102	CCAAT/enhancer binding protein zeta	Rattus norvegicus	61-65
32696344-2	2020	The purpose of this study was to improve the solubility of recombinant bovine sex-determining region Y protein (rbSRY) by exploring the effect of temperature, inducer, and water-arginine mixed solvent.	Water	172-177	sex-determining region Y protein	Bos taurus	78-110
32696344-4	2020	A three-dimensional model of SRY was built and studied through molecular dynamics simulations in water and in the presence of L-arginine as co-solvent.	Water	97-102	sex-determining region Y protein	Bos taurus	29-32
32826239-1	2020	OBJECTIVE: Aquaporin-5 (AQP5) is a member of a family of water channel proteins involved in the bidirectional transfer of water across cell membranes.	Water	57-62	aquaporin 5	Homo sapiens	11-22
8535169-2	1995	Membrane fluidity was dependent on the accumulation of trehalose not hsp104 and non-freezing cell water was dependent on the accumulation of hsp104 not trehalose.	Water	98-103	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	141-147
32826239-1	2020	OBJECTIVE: Aquaporin-5 (AQP5) is a member of a family of water channel proteins involved in the bidirectional transfer of water across cell membranes.	Water	57-62	aquaporin 5	Homo sapiens	24-28
32826239-1	2020	OBJECTIVE: Aquaporin-5 (AQP5) is a member of a family of water channel proteins involved in the bidirectional transfer of water across cell membranes.	Water	122-127	aquaporin 5	Homo sapiens	11-22
32826239-1	2020	OBJECTIVE: Aquaporin-5 (AQP5) is a member of a family of water channel proteins involved in the bidirectional transfer of water across cell membranes.	Water	122-127	aquaporin 5	Homo sapiens	24-28
32999891-0	2020	A Spatially Variable Time Series of Sea Level Change Due to Artificial Water Impoundment.	Water	71-76	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	36-39
7650494-4	1995	The administration of an I-Ag7-binding immunogenic peptide, lambda repressor (cI) 12-26, in a water and oil emulsion (incomplete Freund"s adjuvant) can prevent the transfer of IDDM into irradiated recipients by spleen cells from diabetic donors.	Water	94-99	I-ag7	Mus musculus	25-30
32999891-1	2020	The artificial impoundment of water behind dams causes global mean sea level (GMSL) to fall as reservoirs fill but also generates a local rise in sea level due to the increased mass in the reservoir and the crustal deformation this mass induces.	Water	30-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	67-70
32999891-1	2020	The artificial impoundment of water behind dams causes global mean sea level (GMSL) to fall as reservoirs fill but also generates a local rise in sea level due to the increased mass in the reservoir and the crustal deformation this mass induces.	Water	30-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	146-149
32999891-2	2020	To estimate spatiotemporal fluctuations in sea level due to water impoundment, we use a historical data set that includes 6,329 reservoirs completed between 1900 and 2011, as well as projections of 3,565 reservoirs that are expected to be completed by 2040.	Water	60-65	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	43-46
7642635-8	1995	The simple glycosylases, lacking the concomitant AP lyase activity, are propose to use some nucleophile from the medium, e.g. an activated water molecule.	Water	139-144	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	49-57
32614761-2	2020	nov., a member of the family Alteromonadaceae isolated from marine water of the Arabian Gulf.	Water	67-72	cellular communication network factor 3	Homo sapiens	0-3
32240574-3	2020	Under the optimized conditions, good linearity between the peak areas and the concentrations of the analytes was achieved in the concentration range of 0.5-300 ng mL-1 for water samples, and in the concentration range of 6.0-2700 ng g-1 for soil samples.	Water	172-177	L1 cell adhesion molecule	Mus musculus	163-167
7649312-1	1995	A recent X-ray structural analysis of M. luteus catalase indicates heme-bound H2O trans to the proximal tyrosinate ligand, a finding in contrast to previous X-ray data reporting a 5-coordinate heme for bovine liver catalase.	Water	78-81	catalase	Bos taurus	48-56
8527674-8	1995	The sites that dominate relaxation-and produce contrast in magnetic resonance imaging (MRI), which derives from 1/T1 and 1/T2 of tissue water protons-have tau M approximately 10(-6)s. These, which involve four hydrogen bonds, occupy &lt; or = 1% of the protein-water interface.	Water	261-266	interleukin 1 receptor like 1	Homo sapiens	114-122
32361287-1	2020	Gas bubbles are introduced in water to absorb or strip volatile substances in a variety of unit operations, for example during (waste)water treatment.	Water	30-35	gastrin	Homo sapiens	0-3
32361287-1	2020	Gas bubbles are introduced in water to absorb or strip volatile substances in a variety of unit operations, for example during (waste)water treatment.	Water	134-139	gastrin	Homo sapiens	0-3
7631792-2	1995	In this study, the CNS effects of TRH on ileal and jejunal water transport were examined in awake rats and dogs, respectively.	Water	59-64	thyrotropin releasing hormone	Rattus norvegicus	34-37
32601866-10	2021	The present investigation supported that OW can be reused as a value-added biosorbent product for the removal of Cd2+ from the contaminated water.	Water	140-145	CD2 molecule	Homo sapiens	113-116
32610585-2	2020	In this study, we investigated the effects of the water extract of L. christinae (WELC) on receptor activator of nuclear factor-kappa Beta ligand (RANKL)-induced osteoclastic differentiation of bone marrow macrophages, and on osteoporosis and obesity in ovariectomy mice.	Water	50-55	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	147-152
7631792-8	1995	These results indicate that 1) TRH acts within the CNS to stimulate net ileal and jejunal water secretion in rats and dogs, respectively; 2) these actions are mediated by vagal pathways; and 3) stimulation of intestinal secretion by cerebral TRH is primarily mediated by a VIP-sensitive mechanism and, in part, by a muscarinic mechanism.	Water	90-95	thyrotropin releasing hormone	Rattus norvegicus	31-34
7490266-2	1995	When rats were immersed in a water bath at 42 degrees C for 20 min, the levels of hsp27 in most tissues, including central nervous tissue, liver, lung, spleen, adrenal glands, and hypophysis, had increased dramatically 8 to 16 h after the treatment.	Water	29-34	heat shock protein family B (small) member 1	Rattus norvegicus	82-87
32604746-0	2020	Controlling the Size and Pattern Pitch of Ni(OH)2 Nanoclusters Using Dip-Pen Nanolithography to Improve Water Oxidation.	Water	104-109	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	73-76
7580833-1	1995	In an attempt to determine whether immunization of healthy HIV-1 seronegative individuals with a soluble gp160 candidate vaccine could induce an anti-HIV specific immune response, volunteers were immunized by two injections of a water-in-oil emulsion containing a mixture of gp160 antigen together with selected peptides.	Water	229-234	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	105-110
32637765-2	2020	In this paper, pyrolysis coke was used as a carrier for modification by using gases (H2O, CO2, and NH3), and the optimal modified gas was selected.	Water	85-88	gastrin	Homo sapiens	78-81
32637765-6	2020	The results show that the optimal gas is H2O, and the optimal preparation conditions are 450 mL/min, 650  C, and 60 min.	Water	41-44	gastrin	Homo sapiens	34-37
32458893-10	2020	Additionally, molecular dynamics simulation on MP2 (Moller-Plesset perturbation theory) ground state of small clusters of pyruvic acid with four water molecules were calculated and used in computing the vertical excitation spectrum along the dynamics.	Water	145-150	tryptase pseudogene 1	Homo sapiens	47-50
32535720-8	2020	An efficient, regenerable, and stable sensor device was fabricated for sensitive and selective detection of Cd2+ in contaminated water samples.	Water	129-134	CD2 molecule	Homo sapiens	108-111
32350117-7	2020	Site-specific replacement of active-site amino acids revealed the presence of a water-coordinating aspartate residue that limits esterase activity.	Water	80-85	AT695_RS05650	Staphylococcus aureus	129-137
32426206-4	2020	At the best lipase cocktail, reaction parameters [temperature, biocatalyst content and molar ratio (water/oil)] were optimized by a Central Composite Design, allowing to obtain more than 98% of conversion in the hydrolysis of coconut oil in 3 h of incubation at 37 kHz, 300 W and 45  C by using 20% of the lipase cocktail (w/w) and a molar ratio of 7.5:1 (water/oil).	Water	100-105	PAN0_003d1715	Moesziomyces antarcticus	12-18
32426206-4	2020	At the best lipase cocktail, reaction parameters [temperature, biocatalyst content and molar ratio (water/oil)] were optimized by a Central Composite Design, allowing to obtain more than 98% of conversion in the hydrolysis of coconut oil in 3 h of incubation at 37 kHz, 300 W and 45  C by using 20% of the lipase cocktail (w/w) and a molar ratio of 7.5:1 (water/oil).	Water	100-105	PAN0_003d1715	Moesziomyces antarcticus	306-312
32426206-4	2020	At the best lipase cocktail, reaction parameters [temperature, biocatalyst content and molar ratio (water/oil)] were optimized by a Central Composite Design, allowing to obtain more than 98% of conversion in the hydrolysis of coconut oil in 3 h of incubation at 37 kHz, 300 W and 45  C by using 20% of the lipase cocktail (w/w) and a molar ratio of 7.5:1 (water/oil).	Water	356-361	PAN0_003d1715	Moesziomyces antarcticus	12-18
32423671-1	2020	We have reported previously that the water extract of the earthworm Eisenia fetida has inhibitory effect on human dipeptidyl-peptidase IV (DPP IV) in vitro.	Water	37-42	dipeptidyl peptidase 4	Homo sapiens	114-137
32423671-1	2020	We have reported previously that the water extract of the earthworm Eisenia fetida has inhibitory effect on human dipeptidyl-peptidase IV (DPP IV) in vitro.	Water	37-42	dipeptidyl peptidase 4	Homo sapiens	139-145
32423671-2	2020	Here we studied to identify DPP IV inhibitors in a low-molecular mass extract (designated U3EE) under 3 kDa prepared from the water extract.	Water	126-131	dipeptidyl peptidase 4	Homo sapiens	28-34
32112796-8	2020	Intestinal tissues and derived enteroids from MYO5B(P663L) piglets had reduced apical levels and diffuse sub-apical levels of NHE3 and SGLT1, which regulate transport of sodium, glucose, and water, compared with tissues from control piglets.	Water	191-196	solute carrier family 5 member 1	Sus scrofa	135-140
31926603-12	2020	At the molecular levels, the effects of the phytogenic water additives seemed to be mediated by the activation of the hypothalamic AgRP-ORX-mTOR-S6k1 and inhibition of CRH pathways.	Water	55-60	agouti related neuropeptide	Gallus gallus	131-135
31926603-12	2020	At the molecular levels, the effects of the phytogenic water additives seemed to be mediated by the activation of the hypothalamic AgRP-ORX-mTOR-S6k1 and inhibition of CRH pathways.	Water	55-60	corticotropin releasing hormone	Gallus gallus	168-171
32120108-6	2020	The aim of this study was to identify the toxic effects that the pollutants present in the water of the Madin Dam can generate on a human cell line (SH SY5Y) evaluating the cell viability and the participation of the Aril Hydrocarbon Receptor (AhR) and Pregnane X receptor (PXR) through of the expression of the CYP1A1 and CYP3A4 (canonical genes).	Water	91-96	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	312-318
32486031-2	2020	We have recently provided in vitro evidence that, compared to V2R-wt, expression of activating V2R mutations R137L, R137C and F229V cause a constitutive redistribution of the AQP2 water channel to the plasma membrane, higher basal water permeability and significantly higher basal levels of p256-AQP2 in the F229V mutant but not in R137L or R137C.	Water	180-185	aquaporin 2	Homo sapiens	175-179
32486031-2	2020	We have recently provided in vitro evidence that, compared to V2R-wt, expression of activating V2R mutations R137L, R137C and F229V cause a constitutive redistribution of the AQP2 water channel to the plasma membrane, higher basal water permeability and significantly higher basal levels of p256-AQP2 in the F229V mutant but not in R137L or R137C.	Water	180-185	aquaporin 2	Homo sapiens	296-300
32486031-2	2020	We have recently provided in vitro evidence that, compared to V2R-wt, expression of activating V2R mutations R137L, R137C and F229V cause a constitutive redistribution of the AQP2 water channel to the plasma membrane, higher basal water permeability and significantly higher basal levels of p256-AQP2 in the F229V mutant but not in R137L or R137C.	Water	231-236	aquaporin 2	Homo sapiens	175-179
32486031-2	2020	We have recently provided in vitro evidence that, compared to V2R-wt, expression of activating V2R mutations R137L, R137C and F229V cause a constitutive redistribution of the AQP2 water channel to the plasma membrane, higher basal water permeability and significantly higher basal levels of p256-AQP2 in the F229V mutant but not in R137L or R137C.	Water	231-236	aquaporin 2	Homo sapiens	296-300
32348117-3	2020	Here, we propose a real integrated device consisting of two series-connected perovskite solar cells (PSCs) and two CoP catalyst electrodes, which can be immersed into the aqueous solution directly for solar-driven water splitting.	Water	214-219	caspase recruitment domain family member 16	Homo sapiens	115-118
32455785-3	2020	In the present study, protocols based on a short-term CIDR treatment and a single subcutaneous dose of GnRH in propylene-glycol at 36 h after CIDR removal induced a similar ovarian response to protocols based on administration of eCG at CIDR removal or intramuscular GnRH in distilled water at 56 h after.	Water	285-290	Progonadoliberin-1	Ovis aries	103-107
32151689-3	2020	17-DMAG is a water soluble Hsp90 inhibitor, which was proved to be effective for advanced solid tumors and hematological malignancy.	Water	13-18	heat shock protein 90 alpha family class A member 1	Homo sapiens	27-32
32113540-5	2020	It was estimated to be 10-7 g mL-1 and 10-6 g mL-1 for water and ethanol solutions, respectively.	Water	55-60	L1 cell adhesion molecule	Mus musculus	30-50
32319478-6	2020	In addition, enhanced X-ray excited afterglow imaging can be observed in Nd3+/Cr3+ codoped nanoparticles dispersed in water, human serum albumin solution and simulated lysosomal environment compared to the Cr3+ singly doped nanoparticles.	Water	118-123	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	73-76
32380695-7	2020	EAU induction increased the levels of cytokines (interleukin (IL)-1alpha, IL-1beta, IL-4, IL-6, IL-12, IL-17, and tumor necrosis factor (TNF)-alpha) and chemokines (monocyte chemoattractant protein (MCP)-1) in the retinas of wild-type mice but not in those of Ncf1-/- mice.	Water	0-3	interleukin 1 alpha	Mus musculus	49-72
32380695-7	2020	EAU induction increased the levels of cytokines (interleukin (IL)-1alpha, IL-1beta, IL-4, IL-6, IL-12, IL-17, and tumor necrosis factor (TNF)-alpha) and chemokines (monocyte chemoattractant protein (MCP)-1) in the retinas of wild-type mice but not in those of Ncf1-/- mice.	Water	0-3	interleukin 1 alpha	Mus musculus	74-82
32380695-7	2020	EAU induction increased the levels of cytokines (interleukin (IL)-1alpha, IL-1beta, IL-4, IL-6, IL-12, IL-17, and tumor necrosis factor (TNF)-alpha) and chemokines (monocyte chemoattractant protein (MCP)-1) in the retinas of wild-type mice but not in those of Ncf1-/- mice.	Water	0-3	interleukin 4	Mus musculus	84-88
32380695-7	2020	EAU induction increased the levels of cytokines (interleukin (IL)-1alpha, IL-1beta, IL-4, IL-6, IL-12, IL-17, and tumor necrosis factor (TNF)-alpha) and chemokines (monocyte chemoattractant protein (MCP)-1) in the retinas of wild-type mice but not in those of Ncf1-/- mice.	Water	0-3	neutrophil cytosolic factor 1	Mus musculus	260-264
32380695-9	2020	However, the level of NF-kappaB activity in Ncf1-/- mice with EAU induction was low.	Water	62-65	neutrophil cytosolic factor 1	Mus musculus	44-48
32219907-1	2020	Vasopressin regulates renal water excretion by binding to a Galpha s-coupled receptor (V2R) in collecting duct cells, resulting in increased water permeability through regulation of the aquaporin-2 (AQP2) water channel.	Water	28-33	aquaporin 2	Homo sapiens	186-197
32219907-1	2020	Vasopressin regulates renal water excretion by binding to a Galpha s-coupled receptor (V2R) in collecting duct cells, resulting in increased water permeability through regulation of the aquaporin-2 (AQP2) water channel.	Water	141-146	aquaporin 2	Homo sapiens	186-197
32219907-1	2020	Vasopressin regulates renal water excretion by binding to a Galpha s-coupled receptor (V2R) in collecting duct cells, resulting in increased water permeability through regulation of the aquaporin-2 (AQP2) water channel.	Water	141-146	aquaporin 2	Homo sapiens	199-203
32219907-1	2020	Vasopressin regulates renal water excretion by binding to a Galpha s-coupled receptor (V2R) in collecting duct cells, resulting in increased water permeability through regulation of the aquaporin-2 (AQP2) water channel.	Water	141-146	aquaporin 2	Homo sapiens	186-197
32219907-1	2020	Vasopressin regulates renal water excretion by binding to a Galpha s-coupled receptor (V2R) in collecting duct cells, resulting in increased water permeability through regulation of the aquaporin-2 (AQP2) water channel.	Water	141-146	aquaporin 2	Homo sapiens	199-203
32160957-7	2020	The modified neurological severity score, modified limb placing test score, brain water content and evans blue content were reduced after transplanted miR-126-modified MSCs.	Water	82-87	microRNA 126b	Rattus norvegicus	151-158
32372285-4	2020	In the present study, we screened for novel [Na+] sensors involved in water intake control and identified SLC9A4 (also called sodium (Na+)/hydrogen (H+) exchanger 4 (NHE4)).	Water	70-75	solute carrier family 9 (sodium/hydrogen exchanger), member 4	Mus musculus	166-170
32372285-8	2020	slc9a4 knockdown in the OVLT reduced water intake induced by increases in [Na+], but not osmolality, in the cerebrospinal fluid.	Water	37-42	solute carrier family 9 (sodium/hydrogen exchanger), member 4	Mus musculus	0-6
32372285-9	2020	ICV injection experiments of a specific inhibitor suggested that the increase in extracellular [H+] caused by SLC9A4 activation next stimulates acid-sensing channel 1a (AS1C1a) to induce water intake.	Water	187-192	solute carrier family 9 (sodium/hydrogen exchanger), member 4	Mus musculus	110-116
32372285-10	2020	Our results thus indicate that SLC9A4 in the OVLT functions as a [Na+] sensor for the control of water intake and that the SLC9A4 signal is independent of the Nax/TRPV4 pathway.	Water	97-102	solute carrier family 9 (sodium/hydrogen exchanger), member 4	Mus musculus	31-37
32426673-8	2020	Although its mechanism of action is not well understood, it is thought that inhaled sodium bicarbonate neutralizes the hydrochloric acid formed when the chlorine gas reacts with the water in the lungs.	Water	182-187	gastrin	Homo sapiens	162-165
32390848-2	2020	We found that the water extract of D. morbiferus leaves significantly inhibited tyrosinase activity and melanin formation in alpha-melanocyte stimulating hormone (MSH)-induced B16-F10 cells.	Water	18-23	tyrosinase	Mus musculus	80-90
32391500-6	2020	Lastly, the validity and applicability of the developed electrochemical sensor for the detection of Cd2+ ions were checked in real water samples, and 100% recovery was obtained.	Water	131-136	CD2 molecule	Homo sapiens	100-103
32212710-5	2020	At corn oil/water interfaces, the pH-dependent emulsifying function of zein protein, which is the major storage protein of corn, was elucidated by surface/interface-sensitive sum frequency generation (SFG) vibrational spectroscopy technique.	Water	12-17	zein	Zea mays	71-75
32212710-6	2020	The effective stabilization of corn oil droplets by zein protein was illustrated and correlated to its ordered amide I group at the oil/water interface.	Water	136-141	zein	Zea mays	52-56
32212710-9	2020	The ordered zein proteins at the interface were therefore revealed to be the critical factor for the formation of corn oil-water emulsion.	Water	123-128	zein	Zea mays	12-16
32363291-0	2020	Stability of the Liquid Water Phase on Mars: A Thermodynamic Analysis Considering Martian Atmospheric Conditions and Perchlorate Brine Solutions.	Water	24-29	methionyl-tRNA synthetase 1	Homo sapiens	39-43
32363291-1	2020	The stability of the liquid water phase on Mars has been examined on the basis of fundamental thermodynamic principles.	Water	28-33	methionyl-tRNA synthetase 1	Homo sapiens	43-47
32363291-3	2020	Because of the very low atmospheric pressure on Mars, water cannot exist in the liquid form.	Water	54-59	methionyl-tRNA synthetase 1	Homo sapiens	48-52
32363291-10	2020	Thus, in the extreme and uneventful conditions of saturation by mixtures of salts, liquid water can be stable on Mars between 180 K and at least up to 298 K. Below this temperature, water exists as a glacier and above, as steam only.	Water	90-95	methionyl-tRNA synthetase 1	Homo sapiens	113-117
32363291-10	2020	Thus, in the extreme and uneventful conditions of saturation by mixtures of salts, liquid water can be stable on Mars between 180 K and at least up to 298 K. Below this temperature, water exists as a glacier and above, as steam only.	Water	182-187	methionyl-tRNA synthetase 1	Homo sapiens	113-117
32295252-13	2020	Aldosterone-attenuated water reabsorption may be related to decreased trafficking of AQP2 to the plasma membrane.	Water	23-28	aquaporin 2	Rattus norvegicus	85-89
32309747-0	2020	Red-Emitting Carbon Dots as a Dual Sensor for In3+ and Pd2+ in Water.	Water	63-68	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	55-58
32309747-1	2020	We have demonstrated the synthesis, characterization, and application of nitrogen-doped red-emitting carbon dots (NRCDs) for dual sensing of indium (In3+) and palladium (Pd2+) in water.	Water	179-184	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	170-173
32062149-5	2020	In the first catalytic stage, GOx in IrRu-GOx@PEG NPs degraded tumor tissue-sensitive glucose to hydrogen peroxide (H2O2), which cut off the nutrient source of the tumor and inhibited tumor growth by starvation therapy.	Water	116-120	hydroxyacid oxidase 1, liver	Mus musculus	30-33
32062149-6	2020	In the second catalytic stage, IrRu NPs in IrRu-GOx@PEG NPs catalyzed the upstream endogenous H2O2 to highly toxic singlet oxygen 1O2 and O2.	Water	94-98	hydroxyacid oxidase 1, liver	Mus musculus	48-51
32638713-10	2020	Absorption to 200 mg EVA1 or EVA2 resulted in 8-MOP concentrations of 57% or 32% in water, 91% or 80% in plasma, and 93% or 92% in DIPE/toluene, while 200 mg PVC A and PVC B yielded recovery rates of 26% and 10% in water, 76% and 75% in plasma, and 55% and 30% in DIPE/toluene, respectively.	Water	84-89	myelin protein zero like 2	Homo sapiens	21-25
32638713-10	2020	Absorption to 200 mg EVA1 or EVA2 resulted in 8-MOP concentrations of 57% or 32% in water, 91% or 80% in plasma, and 93% or 92% in DIPE/toluene, while 200 mg PVC A and PVC B yielded recovery rates of 26% and 10% in water, 76% and 75% in plasma, and 55% and 30% in DIPE/toluene, respectively.	Water	215-220	myelin protein zero like 2	Homo sapiens	21-25
32589400-4	2020	The as-prepared FO membrane shows high water permeability of 31.8 L m-2 h-1 and low specific salt flux of 0.27 g L-1 using 2.0 mol L-1 sodium chloride as the draw solution.	Water	39-44	H1.5 linker histone, cluster member	Homo sapiens	72-75
32289203-0	2020	Dual metal active sites in an Ir1/FeOx single-atom catalyst: a redox mechanism for the water-gas-shift reaction.	Water	87-92	nischarin	Homo sapiens	30-33
32289203-2	2020	Here we report a combinedtheoretical and experimental study of the water-gas-shift (WGS) reaction on Ir1/FeOx single-atom catalyst.	Water	67-72	nischarin	Homo sapiens	101-104
32289203-3	2020	It is found that water easily dissociates to OH* on the Ir1 single atom and H* on the nearby O atom bonded with a Fe site.	Water	17-22	nischarin	Homo sapiens	56-59
33318877-0	2021	The coordination of guard-cell autonomous ABA synthesis and DES1 function in situ regulates plant water deficit responses.	Water	98-103	L-cysteine desulfhydrase 1	Arabidopsis thaliana	60-64
32623339-2	2020	However, the available fluorescent probes for detection of lipase activity are only implemented in a hexane-water two-phase system due to the nature of heterogeneous catalysis of lipase, thus limiting their applications in direct imaging of lipase activity in living cells and tissues.	Water	108-113	lipase G, endothelial type	Rattus norvegicus	59-65
32623339-2	2020	However, the available fluorescent probes for detection of lipase activity are only implemented in a hexane-water two-phase system due to the nature of heterogeneous catalysis of lipase, thus limiting their applications in direct imaging of lipase activity in living cells and tissues.	Water	108-113	lipase G, endothelial type	Rattus norvegicus	179-185
32623339-2	2020	However, the available fluorescent probes for detection of lipase activity are only implemented in a hexane-water two-phase system due to the nature of heterogeneous catalysis of lipase, thus limiting their applications in direct imaging of lipase activity in living cells and tissues.	Water	108-113	lipase G, endothelial type	Rattus norvegicus	179-185
32774435-2	2020	Aquaporin 3 (AQP3) plays a vital role in regulating water transfer in the colon.	Water	52-57	aquaporin 3 (Gill blood group)	Rattus norvegicus	0-11
32774435-2	2020	Aquaporin 3 (AQP3) plays a vital role in regulating water transfer in the colon.	Water	52-57	aquaporin 3 (Gill blood group)	Rattus norvegicus	13-17
32774435-3	2020	It has been reported that the downregulation of AQP3 can regulate liquid water metabolism and intestinal permeability in irritable bowel syndrome (IBS) rats" colon via NF-kappaB pathway.	Water	73-78	aquaporin 3 (Gill blood group)	Rattus norvegicus	48-52
32579354-4	2020	These atomically precise metallic clusters were found to be ultra-stable with respect to air for several months, and to water for more than 3 days, due to the stabilizing effects of the TiL3 metalloligand.	Water	120-125	toll like receptor 5	Homo sapiens	186-190
32680992-3	2020	In this study, we hypothesized a labelling of de novo synthesized fatty acids in BSF by the incorporation of deuterated water (D2O) in their feed.	Water	120-125	bicoid stability factor	Drosophila melanogaster	81-84
32540272-5	2020	Here, we tested the capacity of a synthetic TLR-4 adjuvant, SLA-SE (second-generation lipid adjuvant formulated in a squalene-based oil-in-water emulsion) to elicit T cell immunity to a recombinant influenza nucleoprotein (rNP), in both young and aged mice.	Water	139-144	toll like receptor 4	Homo sapiens	44-49
32664509-1	2020	Recently, we have reported that dysfunctions of 67-kDa laminin receptor (67LR) induced by status epilepticus (SE, a prolonged seizure activity) and 67LR neutralization are involved in vasogenic edema formation, accompanied by the reduced aquaporin 4 (AQP4, an astroglial specific water channel) expression in the rat piriform cortex (PC).	Water	280-285	aquaporin 4	Rattus norvegicus	238-249
32664509-1	2020	Recently, we have reported that dysfunctions of 67-kDa laminin receptor (67LR) induced by status epilepticus (SE, a prolonged seizure activity) and 67LR neutralization are involved in vasogenic edema formation, accompanied by the reduced aquaporin 4 (AQP4, an astroglial specific water channel) expression in the rat piriform cortex (PC).	Water	280-285	aquaporin 4	Rattus norvegicus	251-255
32695811-8	2020	On the other hand, both ethanol and water extracts considerably reduced the steady-state mRNA expression of beta-catenin, promoting both cell proliferation and migration in osteosarcoma by regulating target genes.	Water	36-41	catenin beta 1	Homo sapiens	108-120
32645929-4	2020	Pulmonary sodium-potassium-chloride co-transporter 1 (NKCC1) regulates the net influx of ions and water into alveolar cells.	Water	98-103	solute carrier family 12 member 2	Homo sapiens	54-59
32339710-7	2020	Among these hydrogels with different beta-CD-crHA contents, pHEMA/beta-CD-crHA10 hydrogel showed the lowest water contact angle of 52  , the highest water content of 65%, the largest Dk value of 36.4 barrer, and the optimal modulus of 1.8 MPa, as well as a good light transmission of over 90%.	Water	108-113	adrenocortical dysplasia	Mus musculus	66-73
32339710-7	2020	Among these hydrogels with different beta-CD-crHA contents, pHEMA/beta-CD-crHA10 hydrogel showed the lowest water contact angle of 52  , the highest water content of 65%, the largest Dk value of 36.4 barrer, and the optimal modulus of 1.8 MPa, as well as a good light transmission of over 90%.	Water	149-154	adrenocortical dysplasia	Mus musculus	66-73
32196819-5	2020	EC-targeted overexpression of KLF11 significantly mitigated BBB leakage in ischemic brains, evidenced by significantly reduced extravasation of BBB tracers and infiltration of peripheral immune cells, and less brain water content.	Water	216-221	Kruppel-like factor 11	Mus musculus	30-35
32629838-6	2020	Such changes brought by the addition of Ca2+ enabled the significant increase of water permeability (increasing from 17.9 L m-2 h-1 bar-1 to 29.8 L m-2 h-1 bar-1) while maintaining a high selectivity (Na2SO4 rejection rate of 98.0%).	Water	81-86	H1.5 linker histone, cluster member	Homo sapiens	128-131
32629838-6	2020	Such changes brought by the addition of Ca2+ enabled the significant increase of water permeability (increasing from 17.9 L m-2 h-1 bar-1 to 29.8 L m-2 h-1 bar-1) while maintaining a high selectivity (Na2SO4 rejection rate of 98.0%).	Water	81-86	H1.5 linker histone, cluster member	Homo sapiens	152-155
32605195-7	2020	On the other hand, physical interactions between GO and the polyurethane-urea chains were produced when GO was added in water during the synthesis, i.e., GO was acting as a nanofiller, which justified the improved mechanical properties and high lap-shear strength, but poor T-peel strength.	Water	120-125	LAP	Homo sapiens	245-248
32591535-2	2020	Seawater intrusion is particularly likely where water tables lie below sea level, but can also arise from groundwater pumping in some coastal aquifers with water tables above sea level.	Water	3-8	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	71-74
32591535-2	2020	Seawater intrusion is particularly likely where water tables lie below sea level, but can also arise from groundwater pumping in some coastal aquifers with water tables above sea level.	Water	3-8	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	175-178
32213401-5	2020	Among these, all membranes removed chloride but only NF97 and NF90 were able to remove nitrate in compliance with Chilean drinking water standard, showing rejections of 97% and 87%, respectively, in an optimum pressure range of 12-20 bar in which the NF90 produced 3.5 times more permeated water than NF97.	Water	131-136	interleukin enhancer binding factor 3	Homo sapiens	62-66
32189435-2	2020	However, low catalytic efficiency and poor selectivity especially in pure water system hinder the development of photocatalytic CO2RR owing to the lack of effective catalysts.	Water	74-79	complement C2	Homo sapiens	128-133
32189435-4	2020	The Er1/CN-NT as a highly efficient and robust photocatalyst exhibits outstanding CO2RR performance in pure water system.	Water	108-113	complement C2	Homo sapiens	82-87
32571057-3	2020	Using tip-enhanced inelastic electron tunneling spectroscopy (IETS) based on low-temperature scanning tunneling microscopy, we report the direct quantitative assessment of the intermolecular coupling constants of the OH-stretch vibrational bands of an isolated water tetramer adsorbed on a Au(111)-supported NaCl(001) bilayer film.	Water	261-266	TOR signaling pathway regulator	Homo sapiens	6-9
32452684-1	2020	Low temperature anaerobic methane conversion to methanol (MTM) using copper ion-exchanged mordenite (Cu-MOR) as the catalyst and water as the sole source of oxygen is promising for sustainable utilization of methane.	Water	129-134	opioid receptor mu 1	Homo sapiens	104-107
32560242-2	2020	Aquaporin-2 (AQP2), a vasopressin-regulated water channel protein, is known to be selectively excreted into the urine through exosomes (UE-AQP2), and its renal expression is decreased in nephrotic syndrome.	Water	44-49	aquaporin 2	Rattus norvegicus	0-11
32560242-2	2020	Aquaporin-2 (AQP2), a vasopressin-regulated water channel protein, is known to be selectively excreted into the urine through exosomes (UE-AQP2), and its renal expression is decreased in nephrotic syndrome.	Water	44-49	aquaporin 2	Rattus norvegicus	13-17
32560242-2	2020	Aquaporin-2 (AQP2), a vasopressin-regulated water channel protein, is known to be selectively excreted into the urine through exosomes (UE-AQP2), and its renal expression is decreased in nephrotic syndrome.	Water	44-49	aquaporin 2	Rattus norvegicus	139-143
7603774-1	1995	It has been reported that: 1) ovine growth hormone stimulates intestinal water, sodium, and chloride absorption and 2) specific growth hormone receptors are present in the rat intestine.	Water	73-78	gonadotropin releasing hormone receptor	Rattus norvegicus	36-50
32163791-4	2020	The hybrid Pt/EMT nanomaterials could be well dispersed in water to form a homogeneous suspension, and were then utilized as a superior peroxidase-like catalyst for oxidation of 3,3",5,5"-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2).	Water	59-64	IL2 inducible T cell kinase	Homo sapiens	14-17
7603774-1	1995	It has been reported that: 1) ovine growth hormone stimulates intestinal water, sodium, and chloride absorption and 2) specific growth hormone receptors are present in the rat intestine.	Water	73-78	gonadotropin releasing hormone receptor	Rattus norvegicus	128-142
7603774-6	1995	In vivo, growth hormone induced a rapid increase in the absorption rates of water, sodium, chloride, and potassium.	Water	76-81	gonadotropin releasing hormone receptor	Rattus norvegicus	9-23
32511664-5	2020	Results from greenhouse experiments showed that the transgene AtNCED3 and the endogenous genes GmAREB1, GmPP2C, GmSnRK2 and GmAAO3 presented higher expression under water deficit (WD) in the event 2Ha11 than in WT-plants.	Water	165-170	nine-cis-epoxycarotenoid dioxygenase 3	Arabidopsis thaliana	62-69
7711446-3	1995	Kinetic and renal clearance studies of ADH were performed in water-loaded rats and were compared with inulin (glomerular filtration marker) and tetraethylammonium (TEA, marker of organic cation secretion).	Water	61-66	alcohol dehydrogenase 1C (class I), gamma polypeptide	Rattus norvegicus	39-42
7736469-3	1995	The resultant fructosylcyclodextrins (Fru-CDs) show increased solubility in water and, in the case of Fru-beta-CD increased ability to solubilize sparingly soluble compounds by inclusion, relative to the parent cyclodextrins.	Water	76-81	zinc finger and BTB domain containing 22	Homo sapiens	38-41
32131022-0	2020	DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage.	Water	86-91	dual oxidase 2	Rattus norvegicus	0-5
7655189-1	1995	The conformation of a synthetic peptide corresponding to residues 35-53 (SAKM-REWFSETFQKVKEKL) of human apolipoprotein C-I (57 amino acids) was studied by nuclear magnetic resonance and circular dichroism spectroscopy in water and in perdeuterated dodecylphosphocholine solution at 37 degrees C and pH 4.8.	Water	221-226	apolipoprotein C1	Homo sapiens	104-122
7608138-7	1995	The interaction between the CDR3-H peptide and water-soluble PS-derivatives was investigated by inhibition of the ELISA.	Water	47-52	CDR3	Homo sapiens	28-32
7837273-5	1995	In Ala68 deoxymyoglobin, as in the wild-type protein, a water molecule hydrogen-bonded to the N epsilon atom of the distal histidine restricts ligand binding and appears to be more important in regulating the function of myoglobin than direct steric interactions between the ligand and the C gamma atoms of the native valine side-chain.	Water	56-61	myoglobin	Physeter catodon	14-23
7791547-3	1995	Gd-DTPA shortened the apparent relaxation time in the presence of off-resonance saturation pulse (T1a) due to marked shortening of the relaxation time of mobile water (T1w).	Water	161-166	podoplanin	Homo sapiens	98-101
8745066-1	1995	Pretreatment of rats with intrahypothalamic injections of pituitary adenylate cyclase activating peptide (PACAP) 10 min prior to the injection of neuropeptide Y (NPY) significantly reduced food and water intake during the 4-h measurement period.	Water	198-203	adenylate cyclase activating polypeptide 1	Rattus norvegicus	58-104
8745066-1	1995	Pretreatment of rats with intrahypothalamic injections of pituitary adenylate cyclase activating peptide (PACAP) 10 min prior to the injection of neuropeptide Y (NPY) significantly reduced food and water intake during the 4-h measurement period.	Water	198-203	adenylate cyclase activating polypeptide 1	Rattus norvegicus	106-111
8745066-2	1995	Intrahypothalamic injection of PACAP in schedule-fed rats also reduced food and water intake for 2 h. A smaller 1-h reduction of water intake was observed in water-deprived rats, suggesting that the anticonsummatory effects of PACAP were primarily against food intake.	Water	80-85	adenylate cyclase activating polypeptide 1	Rattus norvegicus	31-36
8745066-2	1995	Intrahypothalamic injection of PACAP in schedule-fed rats also reduced food and water intake for 2 h. A smaller 1-h reduction of water intake was observed in water-deprived rats, suggesting that the anticonsummatory effects of PACAP were primarily against food intake.	Water	129-134	adenylate cyclase activating polypeptide 1	Rattus norvegicus	31-36
8745066-2	1995	Intrahypothalamic injection of PACAP in schedule-fed rats also reduced food and water intake for 2 h. A smaller 1-h reduction of water intake was observed in water-deprived rats, suggesting that the anticonsummatory effects of PACAP were primarily against food intake.	Water	129-134	adenylate cyclase activating polypeptide 1	Rattus norvegicus	31-36
7596765-7	1994	These features can be explained by the fact that a tumor containing a large amount of mucin produces a mass of near-water density in the gallbladder on CT.	Water	116-121	LOC100508689	Homo sapiens	86-91
7756988-11	1994	Seventeen water sites were found to be conserved in RNase A structures from 5 different space groups.	Water	10-15	ribonuclease A family member 1, pancreatic	Homo sapiens	52-59
7966440-6	1994	Slight but statistically significant alterations, of uncertain biological significance, resulted from the water treatments: 10% MIX increased alanine aminotransferase, urea nitrogen (BUN), and BUN/creatinine ratio; Restricted Water increased 5"-nucleotidase and decreased alkaline phosphatase.	Water	106-111	5' nucleotidase, ecto	Rattus norvegicus	242-257
7966440-6	1994	Slight but statistically significant alterations, of uncertain biological significance, resulted from the water treatments: 10% MIX increased alanine aminotransferase, urea nitrogen (BUN), and BUN/creatinine ratio; Restricted Water increased 5"-nucleotidase and decreased alkaline phosphatase.	Water	226-231	5' nucleotidase, ecto	Rattus norvegicus	242-257
7847606-1	1994	In a previous study, we showed that a single injection of the thyrotropin-releasing hormone analog TA-0910 dose-dependently reduced alcohol intake in alcohol-preferring (P) rats and increased their water intake over a 24-hr period.	Water	198-203	thyrotropin releasing hormone	Rattus norvegicus	62-91
7978301-2	1994	The eta/T ratio for water (and other common liquids) decreases several-fold for modest temperature gains of approximately 20-60 degrees C, implying a significant advantage for FFF operation at elevated temperatures.	Water	20-25	endothelin receptor type A	Homo sapiens	4-7
32720491-13	2020	In summary, these findings suggest that the AQP4 is an essential protein involved in the regulation of water transport required to create a proper microenvironment for fertilization and egg formation in the hen oviduct.	Water	103-108	aquaporin 4	Gallus gallus	44-48
33312582-9	2020	This research has studied global warming and its effects on the sea level changes of the Caspian Sea and particularly the level of water in the transit channels of the Caspian Sea from the geo-economic point of view.	Water	131-136	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	7-10
33312582-9	2020	This research has studied global warming and its effects on the sea level changes of the Caspian Sea and particularly the level of water in the transit channels of the Caspian Sea from the geo-economic point of view.	Water	131-136	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	176-179
33312582-10	2020	Conclusion: The results show that fluctuations in the water level of the Caspian Sea, in addition to environmental challenges, narrow the balance of its transit channels and threaten the geo-economics and environmental security of the Caspian Sea.	Water	54-59	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	81-84
33312582-10	2020	Conclusion: The results show that fluctuations in the water level of the Caspian Sea, in addition to environmental challenges, narrow the balance of its transit channels and threaten the geo-economics and environmental security of the Caspian Sea.	Water	54-59	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	243-246
32503167-1	2020	The potential barriers governing the motions of alpha-synuclein (alphaS) variants" hydration water, especially energetics of them, is in the focus of the work.	Water	93-98	synuclein alpha	Homo sapiens	48-63
32420243-1	2020	Background: Aquaporin2 (AQP2) is water channel protein that is widely distributed among mammalian tissues and plays a major role in water homeostasis.	Water	33-38	aquaporin 2	Homo sapiens	12-22
32420243-1	2020	Background: Aquaporin2 (AQP2) is water channel protein that is widely distributed among mammalian tissues and plays a major role in water homeostasis.	Water	33-38	aquaporin 2	Homo sapiens	24-28
32420243-1	2020	Background: Aquaporin2 (AQP2) is water channel protein that is widely distributed among mammalian tissues and plays a major role in water homeostasis.	Water	132-137	aquaporin 2	Homo sapiens	12-22
32420243-1	2020	Background: Aquaporin2 (AQP2) is water channel protein that is widely distributed among mammalian tissues and plays a major role in water homeostasis.	Water	132-137	aquaporin 2	Homo sapiens	24-28
32308392-6	2020	Anti-IL-12 treatment with IL-12 monoclonal antibodies could not only significantly decrease the brain water content and EB content in brain tissues of ICH rats, but also significantly increase the score of the Garcia, Beam balance and the Wire hanging test in ICH rats.	Water	102-107	interleukin 12B	Rattus norvegicus	5-10
32308392-6	2020	Anti-IL-12 treatment with IL-12 monoclonal antibodies could not only significantly decrease the brain water content and EB content in brain tissues of ICH rats, but also significantly increase the score of the Garcia, Beam balance and the Wire hanging test in ICH rats.	Water	102-107	interleukin 12B	Rattus norvegicus	26-31
32236245-1	2020	A near-IR perylene diimide probe (OPR-PDI) containing an oxime-propargyl hybrid moiety at the bay position, was designed and synthesized for detection of Pd species and Cu2+ ions in 90% water, the solid state and MG-63 live cells.	Water	186-191	peptidyl arginine deiminase 1	Homo sapiens	38-41
32236245-3	2020	Supramolecular aggregates of OPR-PDI in 90% water act as a dual chemosensor for palladium (Pd) species via de-propargylation or hydrolysis of the Schiff-base and Cu2+ ions via complexation with the O/N binding site with a low limit of detection (LOD) of the order of 7.9 x 10-8 M and 3.4 x 10-7 M respectively.	Water	44-49	peptidyl arginine deiminase 1	Homo sapiens	33-36
32241126-3	2020	We investigate the effect of an antagonistic salt, tetraphenylphosphonium chloride PPh4 +Cl-, in a mixture of water and 2,6-lutidine by means of Molecular Dynamics (MD) simulations.	Water	110-115	potassium two pore domain channel subfamily K member 3	Homo sapiens	83-87
32309726-6	2020	The obtained HKBT4xRNH2 compounds contain 0.4-0.7 n-alkylamine molecules per formula unit as well as the varied amount of intercalated water.	Water	135-140	NLR family pyrin domain containing 4	Homo sapiens	13-23
32130011-3	2020	The water density around the hydrophobic hp1 (17-21) domain is found to be higher for the A2T mutant as compared to the wild-type Abeta and its selected causative mutants.	Water	4-9	chromobox 5	Homo sapiens	41-44
32130011-4	2020	The average tetrahedral order parameter of water molecules around the hydrophobic hp1 (17-21) domain shows that water molecules are less ordered around the A2V, Taiwan, Tottori, and English mutants and more ordered around the A2T mutant than those of the wild-type protein.	Water	43-48	chromobox 5	Homo sapiens	82-85
32130011-4	2020	The average tetrahedral order parameter of water molecules around the hydrophobic hp1 (17-21) domain shows that water molecules are less ordered around the A2V, Taiwan, Tottori, and English mutants and more ordered around the A2T mutant than those of the wild-type protein.	Water	112-117	chromobox 5	Homo sapiens	82-85
32108462-5	2020	Then, we load CdS nanoparticles, which are responsible for absorbing light to produce charge carriers, on A-GO to fabricate a CdS/A-GO photocatalyst without noble metals for the photoreduction of CO2 by H2O.	Water	203-206	CDP-diacylglycerol synthase 1	Homo sapiens	14-17
32005731-3	2020	Under 2 mM H2O2 treatment, the deletion of REV1 resulted in a 1.5- and 2.8-fold decrease in the survival rate and mutation frequency, respectively, whereas overexpression of REV1 increased the survival rate and mutation frequency by 1.1- and 2.9-fold, respectively, as compared to the survival rate and mutation frequency of the wild-type strain.	Water	11-15	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	43-47
32005731-3	2020	Under 2 mM H2O2 treatment, the deletion of REV1 resulted in a 1.5- and 2.8-fold decrease in the survival rate and mutation frequency, respectively, whereas overexpression of REV1 increased the survival rate and mutation frequency by 1.1- and 2.9-fold, respectively, as compared to the survival rate and mutation frequency of the wild-type strain.	Water	11-15	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	174-178
32005731-7	2020	Overall, these findings demonstrate that Sml1 could be a novel regulator that mediates Rev1 dephosphorylation to inhibit its activity during oxidative stress.IMPORTANCE Rev1 was critical for cell growth in S. cerevisiae, and the deletion of REV1 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2 Furthermore, we found that Sml1 physically interacted with Rev1 and inhibited Rev1 phosphorylation, thereby inhibited Rev1 DNA antioxidant activity.	Water	321-325	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	87-91
32005731-7	2020	Overall, these findings demonstrate that Sml1 could be a novel regulator that mediates Rev1 dephosphorylation to inhibit its activity during oxidative stress.IMPORTANCE Rev1 was critical for cell growth in S. cerevisiae, and the deletion of REV1 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2 Furthermore, we found that Sml1 physically interacted with Rev1 and inhibited Rev1 phosphorylation, thereby inhibited Rev1 DNA antioxidant activity.	Water	321-325	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	169-173
32005731-7	2020	Overall, these findings demonstrate that Sml1 could be a novel regulator that mediates Rev1 dephosphorylation to inhibit its activity during oxidative stress.IMPORTANCE Rev1 was critical for cell growth in S. cerevisiae, and the deletion of REV1 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2 Furthermore, we found that Sml1 physically interacted with Rev1 and inhibited Rev1 phosphorylation, thereby inhibited Rev1 DNA antioxidant activity.	Water	321-325	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	169-173
32005731-7	2020	Overall, these findings demonstrate that Sml1 could be a novel regulator that mediates Rev1 dephosphorylation to inhibit its activity during oxidative stress.IMPORTANCE Rev1 was critical for cell growth in S. cerevisiae, and the deletion of REV1 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2 Furthermore, we found that Sml1 physically interacted with Rev1 and inhibited Rev1 phosphorylation, thereby inhibited Rev1 DNA antioxidant activity.	Water	321-325	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	169-173
32005731-7	2020	Overall, these findings demonstrate that Sml1 could be a novel regulator that mediates Rev1 dephosphorylation to inhibit its activity during oxidative stress.IMPORTANCE Rev1 was critical for cell growth in S. cerevisiae, and the deletion of REV1 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2 Furthermore, we found that Sml1 physically interacted with Rev1 and inhibited Rev1 phosphorylation, thereby inhibited Rev1 DNA antioxidant activity.	Water	321-325	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	169-173
32192013-1	2020	Water channel aquaporin 4 (AQP4) plays a key role in the regulation of water homeostasis in the central nervous system (CNS).	Water	0-5	aquaporin 4	Rattus norvegicus	27-31
32192013-1	2020	Water channel aquaporin 4 (AQP4) plays a key role in the regulation of water homeostasis in the central nervous system (CNS).	Water	71-76	aquaporin 4	Rattus norvegicus	27-31
31945433-1	2020	We report here on the green synthesis method of hydrogel nanocomposite (Na-Ala/Chit-cl-polyAAm/CQDs) incorporated with carbon quantum dots for picric acid sensing and biebrich scharlet dye removal from industrial waste water.	Water	219-224	chitinase 1	Homo sapiens	79-83
31965665-2	2020	Two fluorescent probes, Acr1-H2O2 and Acr1-beta-gal , were developed for the fluorescence imaging of H2O2 and beta-galactosidase in vivo.	Water	29-33	peroxiredoxin 5	Homo sapiens	24-28
31965665-2	2020	Two fluorescent probes, Acr1-H2O2 and Acr1-beta-gal , were developed for the fluorescence imaging of H2O2 and beta-galactosidase in vivo.	Water	101-105	peroxiredoxin 5	Homo sapiens	24-28
31965665-2	2020	Two fluorescent probes, Acr1-H2O2 and Acr1-beta-gal , were developed for the fluorescence imaging of H2O2 and beta-galactosidase in vivo.	Water	101-105	peroxiredoxin 5	Homo sapiens	38-42
32256194-6	2020	Moreover, these DCreg can regulate the development of EAU by promoting CD4+CD25+Foxp3+ regulatory T cells.	Water	54-57	forkhead box P3	Mus musculus	80-85
32341230-1	2020	Water-induced pressor response appears mediated through the activation of transient receptor potential channel TRPV4 on hepatic portal circulation in animals.	Water	0-5	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	111-116
31945542-10	2020	Unexpectedly, NEIL1 and NEIL3 were trapped following H2O2 treatment, but not detectably in cells exposed to CuOP.	Water	53-57	nei like DNA glycosylase 1	Homo sapiens	14-19
32104262-4	2020	AQP4 is a water channel protein and mediates water homeostasis in a variety of brain disorders.	Water	10-15	aquaporin 4	Rattus norvegicus	0-4
31894320-7	2020	In addition, downregulation of miR-222 suppressed the inflammatory responses in erythrocyte lysate-induced microglia, and inhibited inflammation, brain water content and improved neurological functions in ICH mice.	Water	152-157	microRNA 222	Mus musculus	31-38
31680354-5	2020	This shared set of genes is enriched for gene ontology terms related to abiotic stress, including water stress and abscisic acid signalling, and includes many genes that are seed-specific in Arabidopsis thaliana and targets of ABI3.	Water	98-103	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	227-231
33612714-9	2020	Hence the best activity was revealed by the water fraction (IC50 of 26.3 and 29.0 microg mL-1) for the two stages.	Water	44-49	L1 cell adhesion molecule	Mus musculus	89-93
32537963-9	2020	There are three tasks of MTP team: 1) defining innovative methods and descriptors to quantify three-dimensional forest structure; 2) developing theories and techniques to measure CO2/H2O fluxes and other trace gases over complex terrains; 3) understanding the relationship between structure and function of forest ecosystems, providing information and rationales for forest management practices to assure broad and sustainable benefits from forests.	Water	183-186	metallothionein 1B	Homo sapiens	25-28
32027503-6	2020	It could detect kanamycin residual in aquatic products including river eel and puffer fish, as well as tap water with high precision.	Water	107-112	filamin B	Homo sapiens	103-106
31998925-5	2020	The addition of 0.30 mg mL-1 graphene into the Triton X-100/C16mimNTf2/H2O LLC system led to a 15% reduction in the friction coefficient and 65% reduction in the wear volume when compared with the pure LLCs.	Water	71-74	L1 cell adhesion molecule	Mus musculus	24-28
32031186-3	2020	The reaction of I-IV with [VIVO(acac)2] leads to the formation of [{VIVO(H2O)}3(ptk(bhz)3)] 1, [{VIVO(H2O)}3(ptk(fah)3)] 2, [{VIVO(H2O)}3(ptk(inh)3)] 3, and [{VIVO(H2O)}3(ptk(nah)3)] 4.	Water	73-76	protein tyrosine kinase 2 beta	Homo sapiens	80-83
32031186-3	2020	The reaction of I-IV with [VIVO(acac)2] leads to the formation of [{VIVO(H2O)}3(ptk(bhz)3)] 1, [{VIVO(H2O)}3(ptk(fah)3)] 2, [{VIVO(H2O)}3(ptk(inh)3)] 3, and [{VIVO(H2O)}3(ptk(nah)3)] 4.	Water	73-76	protein tyrosine kinase 2 beta	Homo sapiens	109-112
32031186-3	2020	The reaction of I-IV with [VIVO(acac)2] leads to the formation of [{VIVO(H2O)}3(ptk(bhz)3)] 1, [{VIVO(H2O)}3(ptk(fah)3)] 2, [{VIVO(H2O)}3(ptk(inh)3)] 3, and [{VIVO(H2O)}3(ptk(nah)3)] 4.	Water	73-76	protein tyrosine kinase 2 beta	Homo sapiens	109-112
32031186-3	2020	The reaction of I-IV with [VIVO(acac)2] leads to the formation of [{VIVO(H2O)}3(ptk(bhz)3)] 1, [{VIVO(H2O)}3(ptk(fah)3)] 2, [{VIVO(H2O)}3(ptk(inh)3)] 3, and [{VIVO(H2O)}3(ptk(nah)3)] 4.	Water	73-76	protein tyrosine kinase 2 beta	Homo sapiens	109-112
32031186-3	2020	The reaction of I-IV with [VIVO(acac)2] leads to the formation of [{VIVO(H2O)}3(ptk(bhz)3)] 1, [{VIVO(H2O)}3(ptk(fah)3)] 2, [{VIVO(H2O)}3(ptk(inh)3)] 3, and [{VIVO(H2O)}3(ptk(nah)3)] 4.	Water	102-105	protein tyrosine kinase 2 beta	Homo sapiens	80-83
32031186-3	2020	The reaction of I-IV with [VIVO(acac)2] leads to the formation of [{VIVO(H2O)}3(ptk(bhz)3)] 1, [{VIVO(H2O)}3(ptk(fah)3)] 2, [{VIVO(H2O)}3(ptk(inh)3)] 3, and [{VIVO(H2O)}3(ptk(nah)3)] 4.	Water	102-105	protein tyrosine kinase 2 beta	Homo sapiens	80-83
32031186-3	2020	The reaction of I-IV with [VIVO(acac)2] leads to the formation of [{VIVO(H2O)}3(ptk(bhz)3)] 1, [{VIVO(H2O)}3(ptk(fah)3)] 2, [{VIVO(H2O)}3(ptk(inh)3)] 3, and [{VIVO(H2O)}3(ptk(nah)3)] 4.	Water	102-105	protein tyrosine kinase 2 beta	Homo sapiens	80-83
31685320-5	2020	Through this adsorption mechanism, the Cd2+ concentration in a contaminated solution could effectively be reduced from 50 ppb to <3 ppb, a WHO limit acceptable for drinking water.	Water	173-178	CD2 molecule	Homo sapiens	39-42
31511857-2	2020	Estrogen, acting via estrogen receptor alpha (ERalpha), regulates gene expression by activating and repressing distinct genes involved in signaling pathways that regulate cellular and physiological responses including cell division, water influx, and immune cell recruitment.	Water	233-238	estrogen receptor 1 (alpha)	Mus musculus	21-44
31511857-2	2020	Estrogen, acting via estrogen receptor alpha (ERalpha), regulates gene expression by activating and repressing distinct genes involved in signaling pathways that regulate cellular and physiological responses including cell division, water influx, and immune cell recruitment.	Water	233-238	estrogen receptor 1 (alpha)	Mus musculus	46-53
32608731-9	2020	In summary, the reed coastal wetland around Bohai Sea demonstrated significantly P storage capacity and served as a P sink for water P. We recommend to fully utilize the coastal wetland to reduce point or non-point source pollution (e.g., P) during the remediation or recovery of the polluted Bohai Sea.	Water	127-132	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	50-53
32095681-2	2020	Imaging in a liquid offers a means to remove contaminations from the surface scanned using the microscope tip when the object is soluble to the surrounding liquid, typically water.	Water	174-179	TOR signaling pathway regulator	Homo sapiens	106-109
31858814-5	2020	The biological significance of miR-132-3p, TUG1, and HDAC3 was assessed using miR-132-3p mimic, siRNA targeting TUG1, and HDAC3 inhibitor RGF966, respectively, in H2O2-challenged cells in vitro or I/R-induced AMI in vivo.	Water	163-167	microRNA 1323	Homo sapiens	31-41
31858814-5	2020	The biological significance of miR-132-3p, TUG1, and HDAC3 was assessed using miR-132-3p mimic, siRNA targeting TUG1, and HDAC3 inhibitor RGF966, respectively, in H2O2-challenged cells in vitro or I/R-induced AMI in vivo.	Water	163-167	microRNA 1323	Homo sapiens	78-88
31858814-7	2020	Overexpressing miR-132-3p or knocking down TUG1 significantly improved viability, inhibited apoptosis, and reduced ROS production in H2O2-stressed cardiomyocytes in vitro, and alleviated I/R-induced AMI in vivo.	Water	133-137	microRNA 1323	Homo sapiens	15-25
31816386-9	2020	On the other hand, we also found that the protective function of curcumin was diminished when PRKAA1 was depleted in IPEC-J2 cells treated with H2O2.	Water	144-148	PRKAA1	Sus scrofa	94-100
31468277-8	2020	Enzyme-linked immunosorbent assay performed on day 7 revealed that hydrogen water reduced the level of the pro-inflammatory cytokine interleukin-6 and increased that of forkhead box P3 transcription factor, suggesting an enhancement of regulatory T cell activity.	Water	76-81	forkhead box P3	Mus musculus	169-184
32065156-0	2020	In situ FTIR Spectroscopy as a Tool for Investigation of Gas/Solid Interaction: Water-Enhanced CO2 Adsorption in UiO-66 Metal-Organic Framework.	Water	80-85	gastrin	Homo sapiens	57-60
31897456-0	2020	Fabrication of a water-soluble near-infrared fluorescent probe for selective detection and imaging of dipeptidyl peptidase IV in biological systems.	Water	17-22	dipeptidyl peptidase 4	Homo sapiens	102-125
31897456-3	2020	Herein, a water-soluble near-infrared (NIR) fluorescent probe HCA-D based on cyanine dyes as the fluorophore and glycyl-prolyl peptide as the specific recognition sequence was developed for the assay of dipeptidyl peptidase IV (DPP-IV) activity.	Water	10-15	dipeptidyl peptidase 4	Homo sapiens	203-226
32635699-10	2020	Brain water content following TBI was significantly different between TBI rats treated with C1-INH (78.7%+-0.12), untreated TBI rats (79.3%+-0.12), and control rats (78.6%+-0.15, P=0.001).	Water	6-11	serpin family G member 1	Rattus norvegicus	92-98
31897456-3	2020	Herein, a water-soluble near-infrared (NIR) fluorescent probe HCA-D based on cyanine dyes as the fluorophore and glycyl-prolyl peptide as the specific recognition sequence was developed for the assay of dipeptidyl peptidase IV (DPP-IV) activity.	Water	10-15	dipeptidyl peptidase 4	Homo sapiens	228-234
7820634-2	1994	Water intake stimulated by peripheral administration of the beta-adrenergic agonist, isoproterenol is attenuated by naloxone and is thought to be mediated by release of renin and production of ANG II.	Water	0-5	renin	Rattus norvegicus	169-174
32039224-5	2020	This study using mouse kidney epithelial cells (TCMK-1) revealed that the level of CHOP (a key marker of ERS), PERK, and JNK (regulators of CHOP) was gradually increased by the prolonged time of hydrogen peroxide (H2O2) stimulation.	Water	214-218	DNA-damage inducible transcript 3	Mus musculus	83-87
32279050-7	2020	Therefore, the present study affords us water-soluble, stable, non-toxic curcuminoids that may serve as lead molecules for development as antibacterial agents against MRSA infections.	Water	40-45	solute carrier family 9 member A6	Homo sapiens	167-171
32105901-0	2020	Hierarchical iron-doped CoP heterostructures self-assembled on copper foam as a bifunctional electrocatalyst for efficient overall water splitting.	Water	131-136	caspase recruitment domain family member 16	Homo sapiens	24-27
32039224-5	2020	This study using mouse kidney epithelial cells (TCMK-1) revealed that the level of CHOP (a key marker of ERS), PERK, and JNK (regulators of CHOP) was gradually increased by the prolonged time of hydrogen peroxide (H2O2) stimulation.	Water	214-218	DNA-damage inducible transcript 3	Mus musculus	140-144
8058761-2	1994	Posttranslational processing of the pD1 protein is essential to establish water oxidation activity of the PSII complex.	Water	74-79	programmed cell death 1	Homo sapiens	36-39
8076651-4	1994	On incubation of purified carboxylester lipase with trioleylglycerol in an ethanol/water mixture, fatty acid ethyl ester was formed in the presence of a high concentration of bovine serum albumin.	Water	83-88	carboxyl ester lipase	Sus scrofa	26-46
32430123-9	2020	It is concluded that dominant in-situ formed Alc after a long time hydrolysis can improve PACl coagulation efficiency in turbidity reduction by enhanced sweep flocculation, especially for low turbidity water, but the increase in preformed Alc in PACl would worsen particle destabilization after aging.	Water	202-207	allantoicase	Homo sapiens	45-48
7825171-1	1994	Aldosterone is known to regulate transmembrane ion transport and water absorption through its binding to mineralocorticoid receptor (MR) in the mammalian colon.	Water	65-70	nuclear receptor subfamily 3 group C member 2	Homo sapiens	105-131
32201244-3	2020	Nesfatin-1 is mainly known for its anorexic properties, but it also controls water intake and glucose homeostasis.	Water	77-82	nucleobindin 2	Homo sapiens	0-10
7825171-1	1994	Aldosterone is known to regulate transmembrane ion transport and water absorption through its binding to mineralocorticoid receptor (MR) in the mammalian colon.	Water	65-70	nuclear receptor subfamily 3 group C member 2	Homo sapiens	133-135
7828083-3	1994	Calmodulin activities in the hormone-sensitive tissues decreased in diabetes and returned to normal after sodium metavanadate or vanadyl sulfate treatment for 3 weeks (0.2, 0.4, and 0.8 mg/mL in drinking water).	Water	204-209	calmodulin 1	Rattus norvegicus	0-10
32459545-3	2021	Although injection of IL-2 complex alone was not capable of decreasing the clinical score of EAU, injection of IL-2 complex/rapamycin significantly delayed the onset of EAU.	Water	169-172	interleukin 2	Mus musculus	111-115
8185601-1	1994	A method is described for incorporation of water-soluble protein Staphylococcal protein A (SpA) into phospholipid monolayer using covalent protein-lipid conjugates in detergent solution.	Water	43-48	surfactant protein A1	Homo sapiens	65-89
32354215-5	2020	Electrolyte impurities, HF and H2O, are reduced early and contribute in a multistep electro-/chemical process to an inorganic SEI layer rich in LiF and Li2CO3.	Water	31-34	LIF interleukin 6 family cytokine	Homo sapiens	144-147
8185601-1	1994	A method is described for incorporation of water-soluble protein Staphylococcal protein A (SpA) into phospholipid monolayer using covalent protein-lipid conjugates in detergent solution.	Water	43-48	surfactant protein A1	Homo sapiens	91-94
32259464-1	2021	OBJECTS: Recent studies indicated that AQP4, as the main water channel in the central CNS, participated in the onset and progression of PD.	Water	57-62	aquaporin 4	Rattus norvegicus	39-43
7512499-11	1994	The administration of GH or IGF-I to GHD rats resulted in significant increases in weight gained, although food and water intake remained unaltered.	Water	116-121	gonadotropin releasing hormone receptor	Rattus norvegicus	22-24
32283025-4	2020	Here we report a new air-stable one-dimensional (1D) hybrid lead-free halide material (DAO)Sn2I6 (DAO: 1,8-octyldiammonium) that is resistant to water for more than 15h.	Water	145-150	D-amino acid oxidase	Homo sapiens	87-90
32330044-2	2020	Through a reaction of a synthetic fluorophlogopite using LiF, MgCl2, and a silica sol in water at 373 K for 48 h in the presence of urea, a hydrated phyllosilicate was formed on the fluoromica.	Water	89-94	LIF interleukin 6 family cytokine	Homo sapiens	57-60
8163584-9	1994	The ability to observe significant changes in rCBF with short stimulation intervals is of particular interest in the use of [15O]water PET for studies of cognitive processes with a short time course.	Water	129-134	CCAAT/enhancer binding protein zeta	Rattus norvegicus	46-50
7513954-0	1994	Extrarenal tissue distribution of CHIP28 water channels by in situ hybridization and antibody staining.	Water	41-46	aquaporin 1	Rattus norvegicus	34-40
7923901-4	1994	Using low dose close renal arterial infusion, ET-1 has potent effects on the kidney causing a marked decrease in effective renal plasma flow and an increase in urine output and free water clearance in the normally hydrated animal.	Water	182-187	EDN1	Ovis aries	46-50
8200490-5	1994	During this developmental window, renin-evoked sodium appetite is dissociated from thirst because (a) NaCl is preferred to water, (b) the appetite develops faster than thirst, and (c) 3-day-old renin-stimulated pups will avidly lick dry NaCl.	Water	123-128	renin	Rattus norvegicus	34-39
8061766-7	1994	Experiments with isolated proximal rabbit tubules incubated with physiological concentrations of 125I-GH demonstrated a time-and dose-dependent increase in unlabelled GH-displaceable cell-associated radioactivity, lending support to the concept of GH mediating its renal effects via proximal tubular GH-R. Short term administration of GH to rats and humans elicited electrolyte and water retention that may cause edema in adults.	Water	382-387	gonadotropin releasing hormone receptor	Rattus norvegicus	102-104
8135830-9	1994	rEP3A and rEP3B receptors are suggested to be derived by alternative RNA splicing, and both receptors are co-localized to distal tubules exerting an effect on water and electrolyte metabolism.	Water	159-164	prostaglandin E receptor 3	Rattus norvegicus	0-5
8135830-9	1994	rEP3A and rEP3B receptors are suggested to be derived by alternative RNA splicing, and both receptors are co-localized to distal tubules exerting an effect on water and electrolyte metabolism.	Water	159-164	prostaglandin E receptor 3	Rattus norvegicus	10-15
7518259-2	1994	The diagnostic value of the water-soluble cytokeratin 19 fragment CYFRA 21-1 in lung cancer was assessed in comparison with carcinoembryonic antigen, squamous cell carcinoma antigen, and neuron-specific enolase.	Water	28-33	keratin 19	Homo sapiens	42-56
8133054-6	1994	We report that in a fluid phase system, SAP inhibited degradation of C4(H2O) (which is C4b-like) in a dose-dependent manner.	Water	72-75	complement C4B (Chido blood group)	Homo sapiens	87-90
8141403-5	1994	It is concluded that the integrity of renin-angiotensin mechanisms is necessary for the rapid ingestion of water and saline after furosemide and captopril and that arterial pressure modulates the behavioral responses.	Water	107-112	renin	Rattus norvegicus	38-43
8192918-4	1994	However, DEF--&gt;NL mice showed markedly altered weight changes when placed on oral ammonium chloride, an effect apparently secondary to dehydration due to decreased water intake.	Water	167-172	UTP25 small subunit processome component	Mus musculus	9-12
8286335-10	1994	It involves the intermediate formation of an electrophilic thiophene sulfoxide, which may react at position 5 of its thiophene ring either with H2O to give 5-OHTA or with a nucleophilic group of an amino acid residue of the P450 active site, which results in its covalent binding to P450 protein.	Water	144-147	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	224-228
8286335-10	1994	It involves the intermediate formation of an electrophilic thiophene sulfoxide, which may react at position 5 of its thiophene ring either with H2O to give 5-OHTA or with a nucleophilic group of an amino acid residue of the P450 active site, which results in its covalent binding to P450 protein.	Water	144-147	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	283-287
8297180-14	1994	ANF may be involved in the pathogenesis of the renal and water and sodium metabolic disturbances present in this disease.	Water	57-62	natriuretic peptides A	Oryctolagus cuniculus	0-3
22059616-6	1994	Water was adequate for myoglobin extraction from raw meat but urea solution was required for adequate extraction of cooked meat samples.	Water	0-5	myoglobin	Ovis aries	23-32
32190275-2	2020	We report on the performance of a newly designed n-butyl-arylazopyrazole butyl sulfonate (butyl-AAP-C4S) surfactant that can change its structure at the air-water interface by E/Z photo-isomerization in an unprecedented way.	Water	157-162	complement C4A (Rodgers blood group)	Homo sapiens	100-103
7939390-7	1994	The small differences in liquid junction potential and water concentration will provide a value for free Mg2+ in plasma of approximately 103% of the true concentration, or 96% of the true molality.	Water	55-60	mucin 7, secreted	Homo sapiens	105-108
31704681-0	2020	Environmental Presence and Genetic Characteristics of Carbapenemase-Producing Enterobacteriaceae from Hospital Sewage and River Water in the Philippines.	Water	128-133	carbapenemase	Escherichia coli	54-67
8250300-2	1993	Application of 15 cm of H2O PEEP for 1 h decreased the levels of plasma ANP and BNP from 24.4 +/- 5.5 (mean +/- SEM) and 19.0 +/- 3.5 fmol/mL to 14.4 +/- 2.1 and 15.3 +/- 3.0 fmol/mL, respectively (P &lt; 0.05).	Water	24-27	natriuretic peptide B	Homo sapiens	80-83
31738360-5	2020	SF4 and SOF2 in the products are removed by washing with water.	Water	57-62	SURP and G-patch domain containing 1	Homo sapiens	0-3
8244713-9	1993	For developmental effects from low-level tritiated water exposures in utero, the risk is uncertain but is estimated to be &lt; 400 x 10(-6) mGy-1.	Water	51-56	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1	Mus musculus	140-145
31447206-0	2020	Gas chromatography and liquid chromatography coupled to mass spectrometry for the determination of fluorotelomer olefins, fluorotelomer alcohols, perfluoroalkyl sulfonamides and sulfonamido-ethanols in water.	Water	202-207	gastrin	Homo sapiens	0-3
7510770-6	1993	The most unexpected finding in this study was that the IGF-I-induced increase in musculo-skeletal carcass weight arose solely from increased water, revealing the importance of this compartment as an early target of IGF-I action.	Water	141-146	insulin-like growth factor 1	Mus musculus	55-60
31407064-5	2020	The roles of AQP4 in the brain water content and neurological function were detected.	Water	31-36	aquaporin 4	Rattus norvegicus	13-17
31407064-8	2020	RESULTS: Following SAH, AQP4 knockout could significantly increase the water content in the whole brain and aggravate the neurological deficits.	Water	71-76	aquaporin 4	Rattus norvegicus	24-28
7510770-6	1993	The most unexpected finding in this study was that the IGF-I-induced increase in musculo-skeletal carcass weight arose solely from increased water, revealing the importance of this compartment as an early target of IGF-I action.	Water	141-146	insulin-like growth factor 1	Mus musculus	215-220
8109748-1	1993	A water-soluble, chemiluminescent substrate for sensitive detection of bacterial phosphatidylinositol-specific phospholipase C (PI-PLC) activity was synthesized.	Water	2-7	phospholipase C beta 1	Homo sapiens	81-126
31778134-9	2020	The imine decomposition products of GP and AMPA are expected to react with water vapour to form simple amines and carbonyl compounds.	Water	75-80	ring finger protein 130	Homo sapiens	36-38
8109748-1	1993	A water-soluble, chemiluminescent substrate for sensitive detection of bacterial phosphatidylinositol-specific phospholipase C (PI-PLC) activity was synthesized.	Water	2-7	phospholipase C beta 1	Homo sapiens	128-134
8311944-1	1993	Intracerebroventricular injection of the putative AT2 agonist, p-aminophenylalanine6 angiotensin II (p-NH2Phe6-Ang II), caused dose-dependent increases in intakes of water and NaCl similar to those produced by angiotensin II but requiring more than one thousand times the dose.	Water	166-171	angiotensin II receptor, type 2	Rattus norvegicus	50-53
32315000-0	2020	Two-dimensional few-layered PC3 as a promising photocatalyst for overall water splitting.	Water	73-78	chromobox 8	Homo sapiens	28-31
32315000-2	2020	In this work, we systematically investigate the stability, electronic properties, optical absorption and photocatalytic water splitting performance of few-layered PC3 by using the first principles calculation method.	Water	120-125	chromobox 8	Homo sapiens	163-166
7694103-5	1993	Supplemental calcium in the diet or drinking water has been reported to decrease the colonic epithelial hyperproliferation induced by bile and fatty acids, enteric resection, a nutritional stress diet, and to suppress induction of the tumor-promotion enzyme ornithine decarboxylase.	Water	45-50	ornithine decarboxylase 1	Homo sapiens	258-281
32315000-3	2020	Numerical results indicate that both monolayered and bilayered PC3 can serve as efficient photocatalysts for overall water splitting due to their high stability, moderate band gaps, suitable band edge positions, anisotropic high carrier mobilities and strong capacity of solar absorption.	Water	117-122	chromobox 8	Homo sapiens	63-66
32315000-5	2020	Moreover, by applying an in-plane biaxial strain, the utilization of solar energy and the pH range suitable for overall water splitting can be improved effectively for both monolayered and bilayered PC3.	Water	120-125	chromobox 8	Homo sapiens	199-202
32106032-8	2020	Moreover, FP was successfully used to rapidly detect trace amounts of hazardous Pb2+ and Cd2+ in tap water with good relative recovery and the relative standard deviations (RSD) were 1.8% for Pb2+ and 0.3% for Cd2+, providing a novel approach for detecting Pb2+ and Cd2+ in practical application.	Water	101-106	CD2 molecule	Homo sapiens	89-92
21244916-2	1993	Among them, its ability to regulate smooth muscle cell contractility and growth, as well as sodium and water homeostasis, making Ang II a major hormone of the cardiovascular system.	Water	103-108	angiogenin	Homo sapiens	129-132
7692851-1	1993	A water soluble protein, RNAse A, was fatty-acylated using AOT reversed micelles in 2,2,4-trimethyl pentane as microreactors and myristoyl chloride as reagent.	Water	2-7	ribonuclease A family member 1, pancreatic	Homo sapiens	25-32
32036330-0	2020	Camel alpha-lactalbumin at the oil-water interface: Effect of protein concentration and pH change on surface characteristics and emulsifying properties.	Water	35-40	lactalbumin alpha	Bos taurus	6-23
8370975-10	1993	All control groups showed a rise in CD4+ cells, with distilled water also producing increases in CD11c+ cells and neutrophils.	Water	63-68	integrin subunit alpha X	Homo sapiens	97-102
32246801-3	2020	Time on the rotarod or calorie consumption, and food and water intake were reduced in the Bmal1-/- mice after MPTP treatment, suggesting that absence of Bmal1 may exacerbate circadian and PD motor function.	Water	57-62	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	90-95
31150667-3	2020	Our pharmacological experiments suggested that Nax signals led to activation of neurons bearing TRPV4 by using epoxyeicosatrienoic acids (EETs) as gliotransmitters to stimulate water intake.	Water	177-182	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	96-101
31150667-9	2020	Collectively, these results indicate that Nax-positive glial cells produce EETs to activate TRPV4-positive neurons which may stimulate water intake, in response to increases in [Na+] of body fluids.	Water	135-140	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	92-97
8223717-0	1993	Localization of the CHIP28 water channel in reabsorptive segments of the rat male reproductive tract.	Water	27-32	aquaporin 1	Rattus norvegicus	20-26
32113684-7	2020	The AQP2 water permeability was measured in oocyte.	Water	9-14	aquaporin 2	Homo sapiens	4-8
32208639-1	2020	We synthesized a generation of water-soluble, atomically precise gold nanoclusters (Au NCs) with anisotropic surface containing short dithiol pegylated chain (AuMHA/TDT).	Water	31-36	deoxynucleotidyltransferase, terminal	Mus musculus	165-168
8223717-1	1993	The water channel protein CHIP28 is responsible for the high constitutive plasma membrane permeability to water of erythrocytes, renal proximal tubule, and thin descending limb of Henle.	Water	4-9	aquaporin 1	Rattus norvegicus	26-32
8223717-1	1993	The water channel protein CHIP28 is responsible for the high constitutive plasma membrane permeability to water of erythrocytes, renal proximal tubule, and thin descending limb of Henle.	Water	106-111	aquaporin 1	Rattus norvegicus	26-32
8223717-9	1993	Therefore, CHIP28 may be a principal mediator of the transmembrane water transport in absorptive epithelial cells of efferent ducts, as well as in epithelial of several other segments of the male reproductive tract that show both secretory and reabsorptive functions.	Water	67-72	aquaporin 1	Rattus norvegicus	11-17
8408864-4	1993	Component 3 had a strong adsorption power superior to that of pancreatic lipase, as shown by tensiometric measurements at an n-tetradecane-water interface.	Water	139-144	pancreatic lipase	Bos taurus	62-79
32341391-0	2020	Analysis of Gas-water Flow Transition Characteristics Based on Multiscale Limited Penetrable Visibility Graph.	Water	16-21	gastrin	Homo sapiens	12-15
32083663-6	2020	We also identify a proton wire water channel for the final deprotonation step, revealing the complete working mechanism for cytosine methylation by DNMT3B and providing the structural basis for DNMT3B mutation-induced hypomethylation in immunodeficiency, centromere instability and facial anomalies syndrome.	Water	31-36	DNA methyltransferase 3 beta	Homo sapiens	148-154
32083663-6	2020	We also identify a proton wire water channel for the final deprotonation step, revealing the complete working mechanism for cytosine methylation by DNMT3B and providing the structural basis for DNMT3B mutation-induced hypomethylation in immunodeficiency, centromere instability and facial anomalies syndrome.	Water	31-36	DNA methyltransferase 3 beta	Homo sapiens	194-200
32063362-4	2020	Human lens epithelial cells expressing AQP1, AQP5 and AQP8, when treated with 50 muM HgCl2 water channel inhibitor showed a significant reduction in H2O2 transport.	Water	91-96	aquaporin 5	Homo sapiens	45-49
32212680-5	2020	The ZnSe nanowires grown on the FTO substrate are further applied as a photoanode in photoelectrochemical (PEC) water splitting.	Water	112-117	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	32-35
32088968-1	2020	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel protein responsible for osmotic water reabsorption by the kidney collecting ducts.	Water	46-51	aquaporin 2	Homo sapiens	0-11
32088968-1	2020	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel protein responsible for osmotic water reabsorption by the kidney collecting ducts.	Water	46-51	aquaporin 2	Homo sapiens	13-17
32088968-1	2020	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel protein responsible for osmotic water reabsorption by the kidney collecting ducts.	Water	92-97	aquaporin 2	Homo sapiens	0-11
32088968-1	2020	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel protein responsible for osmotic water reabsorption by the kidney collecting ducts.	Water	92-97	aquaporin 2	Homo sapiens	13-17
32088968-2	2020	In response to vasopressin, AQP2 traffics from intracellular vesicles to the apical plasma membrane of the collecting duct principal cells where it increases water permeability hence water reabsorption.	Water	158-163	aquaporin 2	Homo sapiens	28-32
32088968-2	2020	In response to vasopressin, AQP2 traffics from intracellular vesicles to the apical plasma membrane of the collecting duct principal cells where it increases water permeability hence water reabsorption.	Water	183-188	aquaporin 2	Homo sapiens	28-32
32089391-7	2020	All of the dimeric bisbenzimidazoles DBPA(n) manifested fluorescent properties, were well soluble in water, nontoxic up to concentrations of 200 microM, and could penetrate into nuclei followed by binding to DNA.	Water	101-106	Y-box binding protein 3	Homo sapiens	37-41
32206983-8	2020	Anti-Stokes UVRR measurements for Mb mutants suggest that the dominant channel for energy transfer in Mb is the pathway through atomic contacts between heme and nearby amino acid residues as well as that between the protein and solvent water.	Water	236-241	myoglobin	Homo sapiens	34-36
32206983-8	2020	Anti-Stokes UVRR measurements for Mb mutants suggest that the dominant channel for energy transfer in Mb is the pathway through atomic contacts between heme and nearby amino acid residues as well as that between the protein and solvent water.	Water	236-241	myoglobin	Homo sapiens	102-104
32237220-2	2020	Their protonation and binding ability for Cu2+ , Zn2+ , Cd2+ and Pb2+ have been studied by coupling potentiometric titrations with UV-vis absorption and fluorescence emission measurements in water.	Water	191-196	CD2 molecule	Homo sapiens	56-59
32280219-7	2020	We observed that water-soluble C60 can alleviate the severity of pulmonary fibrosis by observing the chest computed tomography, pulmonary pathology, and content of collagen, alpha smooth muscle actin and fibronectin in lung.	Water	17-22	fibronectin 1	Mus musculus	204-215
32031808-5	2020	It also counteracted the cell cycle blockade induced by a low concentration of H2O2 decreasing the expression of p21 and CDKN2A (p16INK4A).	Water	79-83	H3 histone pseudogene 16	Homo sapiens	113-116
32114760-5	2020	Specifically, we report the role of a charged Arg45 of myoglobin in destabilizing the transition state when H2O acts as nucleophile, differently to the neutral Pro43 of the hemoglobin subunit.	Water	108-111	myoglobin	Homo sapiens	55-64
33455396-7	2020	The incorporation of alginate also enhanced the mechanical performance of the soft covalent network by forming reversible alginate-Ca2+ ionic cross-links, which interpenetrate through the outer water-retention scaffold with delicate weblike structures.	Water	194-199	POC1 centriolar protein A	Homo sapiens	78-82
32152748-4	2020	Under the optimum conditions, four CPs exhibited good linearity in the range 0.10-80.0 ng mL-1 for water and 2-400 ng g-1 for honey samples with determination coefficient r2 > 0.996.	Water	99-104	L1 cell adhesion molecule	Mus musculus	90-94
32152748-5	2020	The method has low limits of detection of 0.03-0.10 ng mL-1 for water and 0.5-1.0 ng g-1 for honey samples.	Water	64-69	L1 cell adhesion molecule	Mus musculus	55-59
32155736-9	2020	Placement of four B18 chains as a transmembrane bundle results in water channel formation, indicating that B18 may impair membrane integrity and form pores.	Water	66-71	NADH:ubiquinone oxidoreductase subunit B7	Homo sapiens	18-21
32155736-9	2020	Placement of four B18 chains as a transmembrane bundle results in water channel formation, indicating that B18 may impair membrane integrity and form pores.	Water	66-71	NADH:ubiquinone oxidoreductase subunit B7	Homo sapiens	107-110
32131375-1	2020	OBJECTIVES: In the skeletal muscles, water metabolism is mainly regulated by water channel aquaporin 4 (AQP4).	Water	37-42	aquaporin 4	Rattus norvegicus	104-108
31758257-8	2020	An inflammatory environment, as seen during IVD disease, did not affect HYAL-1, HYAL-2 or HYAL-3 expression, whereas exposure to oxidative stress (100 microM H2O2) upregulated HYAL-2 expression relative to untreated controls.	Water	158-162	hyaluronidase 2	Homo sapiens	176-182
31874187-7	2020	We demonstrated that the amount of transporter protein, xCT, localized to the plasma membrane doubles within 10 min of H2O2 exposure as a result of an increase in its delivery rate and a reduction in its internalization rate.	Water	119-123	solute carrier family 7 member 11	Homo sapiens	56-59
32085442-6	2020	By analyses of plant surface permeability, we observed that the hypoxic sensitivities in the LACS2-OEs and lacs2-3 mutant were physiologically correlated with chlorophyll leaching, water loss rates, ionic leakage, and gas exchange.	Water	181-186	long-chain acyl-CoA synthetase 2	Arabidopsis thaliana	93-98
32085442-6	2020	By analyses of plant surface permeability, we observed that the hypoxic sensitivities in the LACS2-OEs and lacs2-3 mutant were physiologically correlated with chlorophyll leaching, water loss rates, ionic leakage, and gas exchange.	Water	181-186	long-chain acyl-CoA synthetase 2	Arabidopsis thaliana	107-112
32149243-0	2020	Electron Inelastic Mean Free Paths for LiF, CaF2, Al2O3, and Liquid Water from 433 keV down to the Energy Gap.	Water	68-73	LIF interleukin 6 family cytokine	Homo sapiens	39-42
31845242-2	2020	This study reported eco-friendly and reusable EPS/Fe3O4 was applied in the sulfonamide-contaminated water treatment, including sulfamethoxazole (SMX), sulfamerazine (SM1), sulfamethazine (SM2) and sulfadiazine (SDZ), respectively.	Water	100-105	SM1	Homo sapiens	166-169
31811544-1	2020	We have previously shown in renal cells that expression of the water channel Aquaporin-2 increases cell proliferation by a regulatory volume mechanism involving Na+/H+ exchanger isoform 2.	Water	63-68	aquaporin 2	Rattus norvegicus	77-88
31811544-9	2020	In conclusion, our data show that, in collecting duct cells, the water channel Aquaporin-2 modulates NHE1-dependent cell proliferation.	Water	65-70	aquaporin 2	Rattus norvegicus	79-90
31761168-6	2020	Due to good electrocatalytic activity of MCHS@MnO2 to H2O2, the immunosensor achieved indirect detection of AFP with wide sensing range from 0.10 ng mL-1 to 420 ng mL-1 and a detection limit of 0.03 ng mL-1.	Water	54-58	L1 cell adhesion molecule	Mus musculus	149-153
31761168-6	2020	Due to good electrocatalytic activity of MCHS@MnO2 to H2O2, the immunosensor achieved indirect detection of AFP with wide sensing range from 0.10 ng mL-1 to 420 ng mL-1 and a detection limit of 0.03 ng mL-1.	Water	54-58	L1 cell adhesion molecule	Mus musculus	164-168
31761168-6	2020	Due to good electrocatalytic activity of MCHS@MnO2 to H2O2, the immunosensor achieved indirect detection of AFP with wide sensing range from 0.10 ng mL-1 to 420 ng mL-1 and a detection limit of 0.03 ng mL-1.	Water	54-58	L1 cell adhesion molecule	Mus musculus	164-168
32237498-6	2020	The results showed that the water extract of C. crocea significantly decreased the number of WBC, NE, EO, increased the number of BA and LY, decreased the levels of TNF-alpha, IL-1beta, IL-6 and the expression of p65 and p-IkappaBalpha protein in NF-kappaB signaling pathway, and effectively alleviated the inflammatory symptoms.	Water	28-33	NFKB inhibitor alpha	Rattus norvegicus	223-235
32099359-12	2020	Conclusion: The optimized formulation consisting of bezafibrate, PVP K30 and cremophor ELP (1/12/1.5, w/w/w) might be a capable drug delivery system for orally administering poorly water-soluble bezafibrate with improved bioavailability and antihyperlipidemic effects.	Water	181-186	elongator acetyltransferase complex subunit 1	Rattus norvegicus	87-100
31973719-6	2020	Effect of IL-24 on H2O2 treated FHs74Int cells and on pdMFs was measured by MTT, LDH, Annexin V assays, real-time RT-PCR and by fluorescent microscopy.	Water	19-23	interleukin 24	Homo sapiens	10-15
31973719-9	2020	IL-24 treatment reduced the number of apoptotic cells (0.5x, p &lt; 0.05) and decreased the expression of inflammatory factors, including IL1A, IL6 and TNF of H2O2-treated FHs74Int cells.	Water	159-163	interleukin 24	Homo sapiens	0-5
31973719-9	2020	IL-24 treatment reduced the number of apoptotic cells (0.5x, p &lt; 0.05) and decreased the expression of inflammatory factors, including IL1A, IL6 and TNF of H2O2-treated FHs74Int cells.	Water	159-163	interleukin 1 alpha	Homo sapiens	138-142
31951594-5	2020	The H2O2-induced premature senescence of MESCs led to increased IGFBP3 in conditioned media (CM).	Water	4-8	insulin like growth factor binding protein 3	Homo sapiens	64-70
31951606-11	2020	Under severe stress (30 muM H2O2) the ratio of electron flow to the thiol network relative to metabolism sinks to 1:251 whereas the ratio of e- flow from NTRC to 2-CysPRX and TRX-f1 to 2-CysPRX rises up to 1:67.	Water	28-32	thioredoxin	Homo sapiens	175-178
31854920-12	2020	The concentrations of PPCPs in the Yellow Sea were higher than of those in the East China Sea, and this was related to there being more sources of pollutions and poor water exchange capacity in the Yellow Sea.	Water	167-172	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	42-45
31830778-5	2020	The direct analysis of water content can be achieved by the four output types, NOT (0, 1), PASS 0 (0, 0), PASS 1 (1, 1), and YES (1, 0).	Water	23-28	HSPB1 associated protein 1	Homo sapiens	106-112
32021088-1	2020	Purpose: Our previous studies have indicated that non-muscle myosin heavy chain IIA (NMMHC IIA) is involved in H2O2-induced neuronal apoptosis, which is associated with the positive feedback loop of caspase-3/ROCK1/MLC pathway.	Water	111-115	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	215-218
32212152-3	2020	The main risk factors contributing to the manifestation or exacerbation of common ocular diseases include exposure to dry air (inside the airplane cabin or in air-conditioned hotel rooms), exposure to chlorinated or salty water (swimming/bathing in swimming pools or in the sea), and sudden changes in the weather conditions.	Water	222-227	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	91-94
30678549-6	2020	It is found that the coefficients are highly comparable to the AQP2 channel though the mechanism of water transport is not similar to AQP 2; the flow of water in the CPN is taking place as a two-line 1-2-1-2 file fashion.	Water	100-105	aquaporin 2	Homo sapiens	63-67
30678549-6	2020	It is found that the coefficients are highly comparable to the AQP2 channel though the mechanism of water transport is not similar to AQP 2; the flow of water in the CPN is taking place as a two-line 1-2-1-2 file fashion.	Water	153-158	aquaporin 2	Homo sapiens	63-67
31908576-5	2020	In cultured VSMCs, hydrogen peroxide (H2O2) dose-dependently induced senescence, which was associated with increased numbers of senescence-associated beta-galactosidase-positive cells, decreased expression of SMP30, and activation of p53-p21 and p16 pathways.	Water	38-42	H3 histone pseudogene 16	Homo sapiens	238-241
31865348-11	2020	In addition, EX4 markedly increased expression of NRF2, HO-1, and NQO-1 and significantly improved protein expression of NRF2 and HO-1 in H2O2-treated ARPE-19 cells, caused by increased nuclear NRF2 protein expression.	Water	138-142	heme oxygenase 1	Homo sapiens	130-134
32594391-4	2020	Gas core is air, or, lately, a perfluorinated gas, poorly soluble in water and blood.	Water	69-74	gastrin	Homo sapiens	0-3
32594391-4	2020	Gas core is air, or, lately, a perfluorinated gas, poorly soluble in water and blood.	Water	69-74	gastrin	Homo sapiens	46-49
32612811-2	2020	In this study, we examined the accuracies of two popular water models, TIP3P and TIP4P, in the molecular dynamics simulations of erythrocyte aquaporins (AQP1 and AQP3).	Water	57-62	aquaporin 3 (Gill blood group)	Homo sapiens	162-166
31568998-5	2020	The observed H/D KIE (alpha = 2.15-1.50) is much larger than what is calculated assuming a classical KIE for Tg = 5000 K (alpha = 1.15) obtained from the sonoluminescence spectra in H2O and D2O.	Water	182-185	adrenoceptor alpha 1D	Homo sapiens	122-131
31568998-6	2020	Furthermore, the alpha values sharply decrease with increasing of H2O content in H2O/D2O mixtures reaching a steady-state value close to alpha = 1.50, which also cannot be explained by O-H/O-D zero-point energy difference.	Water	66-69	adrenoceptor alpha 1D	Homo sapiens	137-146
31568998-6	2020	Furthermore, the alpha values sharply decrease with increasing of H2O content in H2O/D2O mixtures reaching a steady-state value close to alpha = 1.50, which also cannot be explained by O-H/O-D zero-point energy difference.	Water	81-84	adrenoceptor alpha 1D	Homo sapiens	137-146
32138949-4	2020	The effects of AVP peptide includes activation of V2 receptors which stimulate the formation of cyclic AMP (cAMP) and phosphorylation of water channels aquaporin 2 (AQP2) in the collecting duct.	Water	137-142	aquaporin 2	Homo sapiens	152-163
32138949-4	2020	The effects of AVP peptide includes activation of V2 receptors which stimulate the formation of cyclic AMP (cAMP) and phosphorylation of water channels aquaporin 2 (AQP2) in the collecting duct.	Water	137-142	aquaporin 2	Homo sapiens	165-169
31833366-3	2019	The GOx-driven oxidation reaction can effectively eliminate intratumoral glucose for starvation therapy, and the elevated H2O2 is then converted into highly toxic hydroxyl radicals via a Mn2+-mediated Fenton-like reaction for chemodynamic therapy (CDT).	Water	122-126	hydroxyacid oxidase 1, liver	Mus musculus	4-7
31861522-8	2019	Using a PCR-based assay to evaluate mtDNA damage, we demonstrate that overexpression of hTERT in MRC-5 fibroblasts protects mtDNA from H2O2 and NaAsO2 induced damage, compared with their isogenic telomerase-negative counterparts.	Water	135-139	telomerase reverse transcriptase	Homo sapiens	88-93
31851715-2	2019	Aquaporin 2 (AQP2)-dependent water reabsorption in the CD critically depends on the arginine vasopressin (AVP) antidiuretic input and the presence of a favorable osmotic gradient at the apical plasma membrane with tubular lumen being hypotonic compared to the cytosol.	Water	29-34	aquaporin 2	Mus musculus	0-11
31851715-2	2019	Aquaporin 2 (AQP2)-dependent water reabsorption in the CD critically depends on the arginine vasopressin (AVP) antidiuretic input and the presence of a favorable osmotic gradient at the apical plasma membrane with tubular lumen being hypotonic compared to the cytosol.	Water	29-34	aquaporin 2	Mus musculus	13-17
31851715-5	2019	To examine molecular mechanism and physiological relevance of osmosensitivity in the CD, we implemented simultaneous direct measurements of [Ca2+]i dynamics and the rate of cell swelling as a readout of the AQP2-dependent water reabsorption in freshly isolated split-opened CDs of wild type and genetically manipulated animals and combined this with immunofluorescent detection of AVP-induced AQP2 trafficking and assessment of systemic water balance.	Water	222-227	aquaporin 2	Mus musculus	207-211
31851715-8	2019	TRPC3 deletion interfered with AQP2 translocation to the plasma membrane in response to water deprivation.	Water	88-93	aquaporin 2	Mus musculus	31-35
32140643-1	2020	Objective: To investigate the effect of water extract of Gastrodiae Rhizoma (GR) on the development of acquired temporal lobe epilepsy (TLE) and on regulating the expression of the mammalian target of rapamycin (mTOR) and semaphorin 3F (SEMA3F).	Water	40-45	semaphorin 3F	Homo sapiens	222-235
32140643-1	2020	Objective: To investigate the effect of water extract of Gastrodiae Rhizoma (GR) on the development of acquired temporal lobe epilepsy (TLE) and on regulating the expression of the mammalian target of rapamycin (mTOR) and semaphorin 3F (SEMA3F).	Water	40-45	semaphorin 3F	Homo sapiens	237-243
31722522-3	2019	Specifically, Pt blocks deoxyribonucleic acid (DNA) replication and activates hydrogen peroxide (H2O2) generation for chemotherapy; GOx consumes glucose to produce H2O2 and gluconic acid for starvation therapy; and all H2O2 products are catalyzed by ferrous ions decomposed from ferrocene to generate the highly toxic hydroxyl radicals ( OH) for chemodynamic therapy.	Water	164-168	hydroxyacid oxidase 1, liver	Mus musculus	132-135
31722522-3	2019	Specifically, Pt blocks deoxyribonucleic acid (DNA) replication and activates hydrogen peroxide (H2O2) generation for chemotherapy; GOx consumes glucose to produce H2O2 and gluconic acid for starvation therapy; and all H2O2 products are catalyzed by ferrous ions decomposed from ferrocene to generate the highly toxic hydroxyl radicals ( OH) for chemodynamic therapy.	Water	164-168	hydroxyacid oxidase 1, liver	Mus musculus	132-135
31425991-11	2019	Membrane MS2 showed the potential of fractionation of dye and NaCl, which was promising in textile waste water treatment.	Water	105-110	MS2	Homo sapiens	9-12
31816619-7	2019	Brain water content results showed that human recombinant endostatin might aggravate cerebral edema in the acute stage of RBI, but it can reduce the progression of cerebral edema in the early delayed stage.	Water	6-11	collagen type XVIII alpha 1 chain	Homo sapiens	58-68
33417790-6	2019	The Sil-MA water solution with the addition of a photoinitiator (LAP) allows the opening, under UV radiation, of a double carbon-carbon bond and radical polymerization.	Water	11-16	LAP	Homo sapiens	65-68
31812951-4	2019	In SH-SY5Y neuronal cells and primary human neuron cultures, H2O2 downregulated Lnc-EPIC1 and key MYC targets (Cyclin A1, CDC20 and CDC45).	Water	61-65	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	98-101
31812951-4	2019	In SH-SY5Y neuronal cells and primary human neuron cultures, H2O2 downregulated Lnc-EPIC1 and key MYC targets (Cyclin A1, CDC20 and CDC45).	Water	61-65	cyclin A1	Homo sapiens	111-120
31812951-7	2019	MYC knockout by CRISPR/Cas9 method also facilitated H2O2-induced SH-SY5Y cell death.	Water	52-56	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
31812951-8	2019	Significantly, MYC knockout abolished Lnc-EPIC1-induced actions in H2O2-stimulated neuronal cells.	Water	67-71	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	15-18
31817716-9	2019	This H2O2-induced loss of nucleus WHY1 isoform was accompanied by enhanced enrichments of histone H3 lysine 9 acetylation (H3K9ac) and recruitment of RNA polymerase II (RNAP II) globally, and specifically at the promoter of the senescence-related transcription factor WRKY53, which in turn activated WRKY53 transcription and led to a senescence phenotype.	Water	5-9	WRKY family transcription factor	Arabidopsis thaliana	268-274
31817716-9	2019	This H2O2-induced loss of nucleus WHY1 isoform was accompanied by enhanced enrichments of histone H3 lysine 9 acetylation (H3K9ac) and recruitment of RNA polymerase II (RNAP II) globally, and specifically at the promoter of the senescence-related transcription factor WRKY53, which in turn activated WRKY53 transcription and led to a senescence phenotype.	Water	5-9	WRKY family transcription factor	Arabidopsis thaliana	300-306
31787746-3	2019	LncR-TUG1 was upregulated in ischemic heart and in cultured cardiomyocytes exposed to H2O2.	Water	86-90	taurine upregulated gene 1	Mus musculus	5-9
31645458-0	2019	SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K+ and water.	Water	93-98	Salt-inducible kinase 3	Drosophila melanogaster	0-4
31645458-3	2019	Here we identify salt-inducible kinase 3 (SIK3) as the central node in a signal transduction pathway controlling glial K+ and water homeostasis in Drosophila Loss of SIK3 leads to dramatic extracellular fluid accumulation in nerves, neuronal hyperexcitability, and seizures.	Water	126-131	Salt-inducible kinase 3	Drosophila melanogaster	17-40
31645458-3	2019	Here we identify salt-inducible kinase 3 (SIK3) as the central node in a signal transduction pathway controlling glial K+ and water homeostasis in Drosophila Loss of SIK3 leads to dramatic extracellular fluid accumulation in nerves, neuronal hyperexcitability, and seizures.	Water	126-131	Salt-inducible kinase 3	Drosophila melanogaster	42-46
31645458-3	2019	Here we identify salt-inducible kinase 3 (SIK3) as the central node in a signal transduction pathway controlling glial K+ and water homeostasis in Drosophila Loss of SIK3 leads to dramatic extracellular fluid accumulation in nerves, neuronal hyperexcitability, and seizures.	Water	126-131	Salt-inducible kinase 3	Drosophila melanogaster	166-170
31645458-5	2019	SIK3 promotes the cytosolic localization of HDAC4, thereby relieving inhibition of Mef2-dependent transcription of K+ and water transport molecules.	Water	122-127	Salt-inducible kinase 3	Drosophila melanogaster	0-4
31645458-5	2019	SIK3 promotes the cytosolic localization of HDAC4, thereby relieving inhibition of Mef2-dependent transcription of K+ and water transport molecules.	Water	122-127	Myocyte enhancer factor 2	Drosophila melanogaster	83-87
31674811-5	2019	Cardiac myocyte cell culture models were used to determine that oxidant stimulus (i.e. H2O2) alone is sufficient to induce RIalpha protein down-regulation.	Water	87-91	protein kinase, cAMP dependent regulatory, type I, alpha	Mus musculus	123-130
31545194-7	2019	Concerning surface water, the ACT concentrations were found to be at the ppt level.	Water	19-24	palmitoyl-protein thioesterase 1	Homo sapiens	73-76
31890124-8	2019	Treating H2O2-exposed hDPCs with melatonin significantly increased the ratio of apoptotic cells with condensed and deformed nuclei (P &lt; 0.001), as well as the percentage of Annexin V-positive cells (P &lt; 0.01).	Water	9-13	annexin A5	Homo sapiens	176-185
31678145-9	2020	Furthermore, omeprazole protected E. coli cells over-expressing ALDH1A1 from the effects of oxidative stress generated by H2O2 exposure, reducing the levels of lipid aldehydes and preserving ALDH activity.	Water	122-126	aldehyde dehydrogenase 1 family member A1	Homo sapiens	64-71
33134006-1	2020	Background: Green Infrastructure (GI) is defined as a strategically planned network of natural and semi-natural spaces that provide society, in both rural and urban areas, with a large number of goods and services of great value and economic importance such as clean air and water, carbon storage, pollination or protection against the effects of climate change.	Water	275-280	G protein subunit alpha i1	Homo sapiens	34-36
8101699-8	1993	In situ perfusion experiments in intact animals revealed that the ability of morphiceptin (a peptide primarily hydrolyzable by DPP IV), when administered into the intestinal lumen, to block the cholera toxin-induced water secretion was significantly greater in Japan F344 rats than in USA F344 rats, indicating the resistance of morphiceptin to hydrolytic breakdown in the intestinal lumen of the Japan rats.	Water	216-221	dipeptidylpeptidase 4	Rattus norvegicus	127-133
31880404-6	2020	Overexpressed MARCH5 is able to against H2 O2 and ischaemia/reperfusion (I/R) stress by suppressing mitochondrial fission and enhancing mitophagy, and then attenuate cells apoptosis.	Water	40-45	membrane associated ring-CH-type finger 5	Mus musculus	14-20
31603992-9	2019	RESULTS: For a SOBP beam in water, the mean difference at the central axis found for MicroCalc is of 0.86% against 1.03% for PCS.	Water	28-33	sine oculis binding protein homolog	Homo sapiens	15-19
8413028-4	1993	It is shown that for all thick-target bremsstrahlung beams the spr (water/air) = 1.2676-0.002 224[%dd(10)] with a rms deviation of 0.1%.	Water	68-73	sepiapterin reductase	Homo sapiens	63-66
29595091-5	2019	The tempeh water extracts, especially RT-C, reduced the formation of LPS-induced reactive oxygen species, downregulated the levels of nitric oxide synthase and phospho-cyclic-AMP response element-binding protein, and upregulated the expression of brain-derived neurotrophic factor (BDNF).	Water	11-16	brain derived neurotrophic factor	Mus musculus	247-280
29595091-5	2019	The tempeh water extracts, especially RT-C, reduced the formation of LPS-induced reactive oxygen species, downregulated the levels of nitric oxide synthase and phospho-cyclic-AMP response element-binding protein, and upregulated the expression of brain-derived neurotrophic factor (BDNF).	Water	11-16	brain derived neurotrophic factor	Mus musculus	282-286
31924135-6	2020	For both improved treatment processes, CP-contaminated water samples displayed higher values for TOC removal and BOD5/COD ratios than CP-contaminated soil samples.	Water	55-60	ceruloplasmin	Homo sapiens	39-41
31646664-4	2020	The dose-dependent protective effects against H2 O2 -induced oxidative stress of the rutin-Lys MRPs may involve the inhibition of reactive oxygen species generation, enhancement of the superoxide dismutase and catalase activities, along with the activation of the Nrf2-dependent pathway and upregulation of phase II antioxidant genes (including NQO1, HO-1, GCLG, and GCLM).	Water	46-51	heme oxygenase 1	Homo sapiens	351-355
8504099-5	1993	The X-ray crystal structure for mouse adenosine deaminase shows zinc in contact with the attacking water nucleophile using purine riboside as a transition-state inhibitor [Wilson, D. K., Rudolph, F. B., &amp; Quiocho, F. A.	Water	99-104	adenosine deaminase	Mus musculus	38-57
31733428-9	2020	However, a variation between tetrameric Hb(III) on one side and Hp1-1:Hb(III), Hp2-2:Hb(III), alpha(III), and beta(III) on the other side for the rate-limiting step (likely referable to the dissociation of heme-coordinated H2O from the heme-Fe(III) atom) suggests a structural change(s) upon dimers to tetramer assembly in Hb(III).	Water	223-226	chromobox 5	Homo sapiens	64-67
31784665-0	2019	miR302a and 122 are deregulated in small extracellular vesicles from ARPE-19 cells cultured with H2O2.	Water	97-101	microRNA 302a	Homo sapiens	0-7
8504110-7	1993	When present, the phosphoryl transfer activity can be removed by further purification or destroyed over time by resuspension of HPr preparations in water.	Water	148-153	haptoglobin-related protein	Homo sapiens	128-131
31209480-8	2019	Egret-Burke TaMATE1B also had higher concentrations of water-extractable P, Fe and Al in the rhizosphere, indicating the release of mineral-protected C. In addition, citrate ligand facilitated Fe and Al release from soil, with their concentrations rising with increasing ligand concentration and incubation time.	Water	55-60	LOC101664696	Triticum aestivum	12-20
8476867-7	1993	The presence of the protein enhanced the adsorption rate of lipid into the air-water interface when dispersions of lipids or lipid plus SP-B were injected below the interface.	Water	79-84	surfactant protein B	Homo sapiens	136-140
31699336-10	2019	Urea being a denaturant interacts more with these regions of alpha-synuclein through hydrogen bond formation and inhibits the beta-sheet formation, whereas trimethyl amine oxide itself does not interact much with the protein and stabilizes the protein by preferentially distributing water molecules on the surface of the protein.	Water	283-288	synuclein alpha	Homo sapiens	61-76
31546170-2	2020	To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with "peroxiporin" activity (AQP3, AQP8, AQP9).	Water	37-41	aquaporin 3 (Gill blood group)	Homo sapiens	140-144
32378658-5	2020	However, this important variable has been neglected in many prediction methods for oral drug absorption and drug interactions, and for convenience it is often assumed that the GI water volume is fixed at a constant value.	Water	179-184	G protein subunit alpha i1	Homo sapiens	176-178
32378658-7	2020	However, the actual volume of water in the GI tract is both time- and site-dependent as a result of water intake, absorption, secretion, and GI transit.	Water	30-35	G protein subunit alpha i1	Homo sapiens	43-45
32378658-7	2020	However, the actual volume of water in the GI tract is both time- and site-dependent as a result of water intake, absorption, secretion, and GI transit.	Water	30-35	G protein subunit alpha i1	Homo sapiens	141-143
32378658-7	2020	However, the actual volume of water in the GI tract is both time- and site-dependent as a result of water intake, absorption, secretion, and GI transit.	Water	100-105	G protein subunit alpha i1	Homo sapiens	43-45
32378658-8	2020	This review article summarizes our data showing that luminal water volume is influenced by the osmolality of the applied solution, and illustrates how this effect may contribute to changes in GI drug concentration, resulting in altered drug absorption.	Water	61-66	G protein subunit alpha i1	Homo sapiens	192-194
31827676-9	2019	Furthermore, we found that Dnmt3a was significantly downregulated in a porcine anterior lumbar interbody fusion model and was confirmed to be reduced by H2O2 treatment using the 3D in vitro model.	Water	153-157	DNA methyltransferase 3 alpha	Homo sapiens	27-33
31827676-10	2019	The hypomethylation of ALP and RUNX2 induced by H2O2 treatment was abolished by Dnmt3a overexpression.	Water	48-52	DNA methyltransferase 3 alpha	Homo sapiens	80-86
8456103-2	1993	Intracerebroventricular administration of renin reduces urine volume and increases sodium excretion and water intake in conscious, male, hydrated rats.	Water	104-109	renin	Rattus norvegicus	42-47
31788599-0	2019	Mesoporous Layered Graphene Oxide/Fe3O4/C3N3S3 Polymer Hybrids for Rapid Removal of Pb2+ and Cd2+ from Water.	Water	103-108	CD2 molecule	Homo sapiens	93-96
31717476-3	2019	Following daily DEP exposure in mice, pulmonary macrophages were isolated for mitochondrial analyses, revealing reduced respiration rates and dramatically elevated H2O2 levels.	Water	164-168	zinc finger, DHHC domain containing 21	Mus musculus	16-19
8456103-5	1993	Peripheral and central administration of the AT1 receptor blocker significantly lengthened the onset of drinking behavior and reduced the cumulative water intake observed after intracerebroventricular injection of renin.	Water	149-154	renin	Rattus norvegicus	214-219
7679251-0	1993	Tissue-specific expression of mRNA encoding rat kidney water channel CHIP28k by in situ hybridization.	Water	55-60	aquaporin 1	Rattus norvegicus	69-75
31320132-6	2019	The limits of detection (S/N = 3) of the method were 0.2-0.3 ng mL-1 for juice sample and 0.02-0.03 ng mL-1 for water sample.	Water	112-117	L1 cell adhesion molecule	Mus musculus	103-107
7679251-1	1993	The tissue distribution of mRNA encoding rat kidney water channel CHIP28k was determined by in situ hybridization.	Water	52-57	aquaporin 1	Rattus norvegicus	66-72
7679251-19	1993	These results indicate a wide and highly selective tissue distribution of mRNA encoding the CHIP28k water channel.	Water	100-105	aquaporin 1	Rattus norvegicus	92-98
8430786-7	1993	Infusion of either PTH-(1-34), PTHrP-(1-34), or PTHrP-(1-141) also resulted in an increase in fetal urine osmolality and pH and a decrease in free water clearance in TxPTx fetuses.	Water	147-152	parathyroid hormone like hormone	Homo sapiens	31-36
31708994-7	2019	Initial exposure to H2O2 or TNFalpha enhanced SF senescence and increased mRNA expression of IL6, CXCL8, CCL2 and MMP3 and proteins secretion.	Water	20-24	C-C motif chemokine ligand 2	Homo sapiens	105-109
8430786-7	1993	Infusion of either PTH-(1-34), PTHrP-(1-34), or PTHrP-(1-141) also resulted in an increase in fetal urine osmolality and pH and a decrease in free water clearance in TxPTx fetuses.	Water	147-152	parathyroid hormone like hormone	Homo sapiens	48-53
8421053-0	1993	Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28.	Water	79-84	aquaporin 1	Rattus norvegicus	111-117
31625380-3	2019	Here, we show, using the oxidation of alkenes with H2O2 and the catalyst [Mn2(mu-O)3(tmtacn)2](PF6)2 (1), that Lewis acids commonly used to enhance catalytic activity, e.g., Sc(OTf)3, in fact undergo hydrolysis with adventitious water to release a strong Bronsted acid.	Water	51-55	POU class 5 homeobox 1	Homo sapiens	174-182
8421053-12	1993	These results indicate that CHIP28k is a major and highly selective water transporting protein in the kidney proximal tubule and thin descending limb of Henle, but not collecting duct.	Water	68-73	aquaporin 1	Rattus norvegicus	28-34
31521813-14	2019	The results showed that the addition of octyl glucoside (OG) could change the water channel size of LLC, which enabled the LLC system to release VEGF in a sustained manner and to possess a suitable modulus to favor angiogenesis simultaneously.	Water	78-83	vascular endothelial growth factor A	Rattus norvegicus	145-149
8309734-3	1993	Treatment with TRH resulted in significantly increased hypothalamic oxytocin content in both euhydrated (i.e., given tap water ad libitum) and salt-loaded rats and vasopressin content only in euhydrated rats.	Water	121-126	thyrotropin releasing hormone	Rattus norvegicus	15-18
31853247-8	2019	Over-expression of lncRNA MHRT inhibited the apoptosis of human cardiomyocyte cell line AC16 after H2O2 treatment.	Water	99-103	myosin heavy chain associated RNA transcript	Homo sapiens	26-30
8309734-4	1993	Similarly, neurohypophysial vasopressin and oxytocin content significantly increased in animals drinking tap water or 2% sodium chloride during treatment with TRH.	Water	109-114	thyrotropin releasing hormone	Rattus norvegicus	159-162
1282299-0	1992	Localization of the CHIP28 water channel in rat kidney.	Water	27-32	aquaporin 1	Rattus norvegicus	20-26
31276885-10	2019	In addition, the addition of stable organic substances and subsequent formation of water-stable aggregates may be also beneficial for immobilizing PTMs and improving tropical soil quality.	Water	83-88	parathymosin	Bos taurus	147-151
31384860-4	2019	It was revealed that the suppression of hydrogen bonding with water (N-HOH or NH-OH2) is the dominant factor for the fluorescence enhancement on the clay surface for NH2PhP and NMe2PhP.	Water	62-67	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	177-184
1282299-9	1992	CHIP28 is, therefore, present in membranes with a high constitutive water permeability, where it probably acts as a transmembrane water-conducting channel.	Water	68-73	aquaporin 1	Rattus norvegicus	0-6
1282299-9	1992	CHIP28 is, therefore, present in membranes with a high constitutive water permeability, where it probably acts as a transmembrane water-conducting channel.	Water	130-135	aquaporin 1	Rattus norvegicus	0-6
1282299-10	1992	Finally, a weak staining of apical and basolateral membranes of cortical collecting duct principal cells was detectable, suggesting a potential relationship of CHIP28 to the vasopressin-sensitive water channel.	Water	196-201	aquaporin 1	Rattus norvegicus	160-166
1342636-1	1992	The survival of Pseudomonas putida marked with the xylE gene was monitored in lake-water microcosms.	Water	83-88	catechol 2,3-dioxygenase	Pseudomonas putida	51-55
31595752-3	2019	Moreover, DNA photocleavage, singlet oxygen generation in HeLa cells, cellular uptake/localization, and in vitro photodynamic therapy for cancer cells of water-soluble Ru1 are described in detail.	Water	154-159	Scm like with four mbt domains 1	Homo sapiens	168-171
31595752-5	2019	Ru2 exhibited very strong solvatochromism from a visible emission maximum at 588 nm in CH2Cl2 to the near-IR region at 700 nm in water and singlet oxygen generation yield in water (23%) and DNA binding properties (intercalative DNA binding constant on the order of 106 M-1) comparable to those of Ru1, which should make Ru2 attractive for the aforementioned applications of Ru1 if the water solubility of Ru2 can be improved enough for the studies above.	Water	129-134	doublecortin domain containing 2	Homo sapiens	0-3
31595752-5	2019	Ru2 exhibited very strong solvatochromism from a visible emission maximum at 588 nm in CH2Cl2 to the near-IR region at 700 nm in water and singlet oxygen generation yield in water (23%) and DNA binding properties (intercalative DNA binding constant on the order of 106 M-1) comparable to those of Ru1, which should make Ru2 attractive for the aforementioned applications of Ru1 if the water solubility of Ru2 can be improved enough for the studies above.	Water	174-179	doublecortin domain containing 2	Homo sapiens	0-3
31595752-5	2019	Ru2 exhibited very strong solvatochromism from a visible emission maximum at 588 nm in CH2Cl2 to the near-IR region at 700 nm in water and singlet oxygen generation yield in water (23%) and DNA binding properties (intercalative DNA binding constant on the order of 106 M-1) comparable to those of Ru1, which should make Ru2 attractive for the aforementioned applications of Ru1 if the water solubility of Ru2 can be improved enough for the studies above.	Water	174-179	doublecortin domain containing 2	Homo sapiens	0-3
31444200-0	2019	Surface Water Microbial Community Response to the Biocide 2,2-Dibromo-3-Nitrilopropionamide, Used in Unconventional Oil and Gas Extraction.	Water	8-13	gastrin	Homo sapiens	124-127
31444200-9	2019	These findings suggest that past HF activity in streams can affect the microbial community response to environmental perturbation such as that caused by the biocide DBNPA.IMPORTANCE Unconventional oil and gas activity can affect pH, total organic carbon, and microbial communities in surface water, altering their ability to respond to new environmental and/or anthropogenic perturbations.	Water	292-297	gastrin	Homo sapiens	205-208
1280133-0	1992	Isolation of a cDNA for rat CHIP28 water channel: high mRNA expression in kidney cortex and inner medulla.	Water	35-40	aquaporin 1	Rattus norvegicus	28-34
31490498-2	2019	The functionalized methylene bridge of the ligands leads to water soluble complexes, which have been characterized by NMR and IR spectroscopy, elemental analysis and single crystal X-ray diffraction in the case of La-H2-PF6, Ag2(La)2, Ag2(Lb)2 and Au2(La)2.	Water	60-65	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	225-233
31490498-2	2019	The functionalized methylene bridge of the ligands leads to water soluble complexes, which have been characterized by NMR and IR spectroscopy, elemental analysis and single crystal X-ray diffraction in the case of La-H2-PF6, Ag2(La)2, Ag2(Lb)2 and Au2(La)2.	Water	60-65	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	235-243
1280133-1	1992	The cDNA coding for the rat CHIP28 water channel was isolated from a kidney library.	Water	35-40	aquaporin 1	Rattus norvegicus	28-34
1280133-4	1992	The evidence suggests that CHIP28 water channels in the ADH-sensitive collecting tubules are identical to those of the ADH-insensitive proximal convoluted tubules and possibly other tissues specialised in fluid transport.	Water	34-39	aquaporin 1	Rattus norvegicus	27-33
1445935-19	1992	Based on this assumption, we propose that a single isozyme I in water imbibed control wheat aleurones is the product of SAM1 gene of AdoMet synthetase.	Water	64-69	S-adenosylmethionine synthase	Triticum aestivum	133-150
31247606-4	2019	HfO2 AR nanofilms show hydrophilic behaviour before surface modification with a water contact angle (WCA) of 29  on FTO and 22  on sapphire.	Water	80-85	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	116-119
1429615-8	1992	The process of heat activation of GDH from 40 to 80 degrees C is accompanied by a much smaller increase in absorbance at 280 nm and a reversible increase in heat capacity with delta(cal) = 187 Kcal [mol GDH]-1 and Tm = 57 degrees C. This absorbance change as well as the moderate increase in heat capacity suggest that thermal activation leads to some exposure of hydrophobic groups to solvent water as the GDH structure is opened slightly.	Water	394-399	glutamate dehydrogenase 1, mitochondrial	Bos taurus	34-37
31566306-0	2019	H2 O2 -Sensitive Upconversion Nanocluster Bomb for Tri-Mode Imaging-Guided Photodynamic Therapy in Deep Tumor Tissue.	Water	0-5	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	51-54
31411503-6	2019	Casp8 IEC mice fed a CD also showed impaired body weight gain compared with Casp8fl mice, which was even more pronounced in mice receiving water supplemented with fructose.	Water	139-144	caspase 8	Mus musculus	0-5
1444600-7	1992	However, a significant increase in epididymal androgen binding protein level and a decrease in seminal vesicle weight were observed in rats that ingested water containing 1% lead acetate.	Water	154-159	sex hormone binding globulin	Rattus norvegicus	46-70
31063681-2	2019	In the aquaporin (AQP) water channel family, AQP1 and AQP4 play critical roles in the progress of cerebral oedema of various neuropathological events.	Water	23-28	aquaporin 4	Rattus norvegicus	54-58
1383769-6	1992	This was accomplished by P-element transformation of Drosophila melanogaster with the bovine cDNA for CuZn superoxide dismutase, an enzyme that catalyzes the dismutation of the superoxide radical to hydrogen peroxide and water.	Water	221-226	superoxide dismutase [Cu-Zn]	Bos taurus	102-127
31351272-0	2019	Permeation of beta-defensin-3 encapsulated with polyethylene glycol in lung surfactant models at air-water interface.	Water	101-106	defensin beta 103B	Homo sapiens	14-29
31351272-6	2019	The peptide HBD3 was pulled from the polar heads to the water phase overcoming an energy barrier of around 17 and 22 Kcal mol-1, respectively.	Water	56-61	defensin beta 103B	Homo sapiens	12-16
31351272-8	2019	After permeation of the HBD3 encapsulated with PEG, it freely moves in the water phase with little or none interaction with the phospholipid head groups.	Water	75-80	defensin beta 103B	Homo sapiens	24-28
1512262-7	1992	In the R2-state, His-97 beta 2 simply rotates away from threonines 38 alpha 1 and 41 alpha 1, breaking contact with these residues and allowing water access to the center of the alpha 1 beta 2 interface.	Water	144-149	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	186-192
1330569-0	1992	Deuterium oxide (heavy water) arrests the cell cycle of PtK2 cells during interphase.	Water	23-28	protein tyrosine kinase 2	Homo sapiens	56-60
31180595-1	2019	beta-1,3-d-glucan with different degrees of branching were obtained by selectively and gradually removing side chains from schizophyllan, a water-soluble triple helical polysaccharide, using the Smith degradation.	Water	140-145	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	0-8
1511413-1	1992	We have previously reported that phytic acid (inositol hexaphosphate or InsP6), a natural constituent of cereal diet, when administered in drinking water exerts a consistent antitumor effect on experimental colon cancer in vivo.	Water	148-153	inositol hexaphosphate kinase 1	Mus musculus	72-77
31626391-4	2019	Fluorescently labeled desmin, with or without actin, was enclosed in droplets prepared with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) using the water-in-oil method.	Water	155-160	desmin	Homo sapiens	22-28
31228813-9	2019	Taken together, in situ down-regulation of miR-21-5p attenuates EAU by inhibiting inflammatory responses and reducing retinal cell apoptosis.	Water	64-67	microRNA 215	Mus musculus	43-52
1625203-3	1992	Glomerular filtration rate was significantly higher than control after additions of ET-3 as was the absolute and fractional excretion of water and electrolytes.	Water	137-142	endothelin 3	Rattus norvegicus	84-88
31228813-10	2019	miR-21-5p may also participate in the progress of EAU by affecting Th17/Treg balance via the regulation of IL-10.	Water	50-53	microRNA 215	Mus musculus	0-9
34057492-5	2019	Standard addition method was used to apply CNT-Calix/CPE in waste water, plant leaves and soft drinks and it was found that the concentration of Cu(II) and Pb(II) were corresponding to standardized values.	Water	66-71	carboxypeptidase E	Homo sapiens	53-56
31585206-5	2019	In this study, we found that the protein expression of circadian genes Clock, Bmal1, Per1/2, and Cry1/2 in NIH3T3 cells was upregulated by hydrogen peroxide (H2O2), an important mediator of oxidative stress.	Water	158-162	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	78-83
31585206-5	2019	In this study, we found that the protein expression of circadian genes Clock, Bmal1, Per1/2, and Cry1/2 in NIH3T3 cells was upregulated by hydrogen peroxide (H2O2), an important mediator of oxidative stress.	Water	158-162	period circadian clock 1	Mus musculus	85-91
31585206-6	2019	In addition, H2O2 modulated the circadian rhythm of Bmal1-luciferase via RORalpha, REV-ERBalpha (NR1D1), and REV-ERBbeta (NR1D2).	Water	13-17	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	52-57
30961713-1	2019	The tip and inner surface of large diameter multi-walled carbon nanotubes (MWCNTs) (4.9 nm diameter) were functionalized on the tip and inner surface to improve the rate of desalination and maintain high water flux.	Water	204-209	TOR signaling pathway regulator	Homo sapiens	4-7
30961713-1	2019	The tip and inner surface of large diameter multi-walled carbon nanotubes (MWCNTs) (4.9 nm diameter) were functionalized on the tip and inner surface to improve the rate of desalination and maintain high water flux.	Water	204-209	TOR signaling pathway regulator	Homo sapiens	128-131
1319204-2	1992	With histidine decarboxylase (pyruvoyl) it is found that the presence of CO2 is required for T-exchange between histamine and water.	Water	126-131	histidine decarboxylase	Homo sapiens	5-28
31640919-4	2019	Both A2AR and A2BR may stimulate H2O2 production leading to activation of KATP channels in SMCs, we also studied the involvement of H2O2 and KATP channels in Up4A-mediated effect.	Water	33-37	adenosine A2a receptor	Homo sapiens	5-9
31640919-10	2019	Collectively, Up4A-induced porcine coronary SMC relaxation is mediated by activation of A2AR-H2O2 pathway.	Water	93-97	adenosine A2a receptor	Homo sapiens	88-92
10045744-0	1992	Water adsorption on (111) surfaces of BaF2 and CaF2.	Water	0-5	CCR4-NOT transcription complex subunit 8	Homo sapiens	47-51
31493483-6	2019	In vivo evaluations, it was demonstrated that the memory was significantly restored in cognitive deficit rats treated with EPO-SLN compared to the rats treated with native drug using the Morris water maze test.	Water	194-199	erythropoietin	Rattus norvegicus	123-126
31493483-6	2019	In vivo evaluations, it was demonstrated that the memory was significantly restored in cognitive deficit rats treated with EPO-SLN compared to the rats treated with native drug using the Morris water maze test.	Water	194-199	sarcolipin	Rattus norvegicus	127-130
1586659-7	1992	Further experiments with purified rat liver nonspecific lipid transfer protein and pyrene-labeled phosphatidylcholine and phosphatidylserine have shown that cations by neutralizing net negative charge on phospholipid donor vesicles decrease the interaction of protein with them and, in consequence, lower the rate of release of molecules to the water phase.	Water	345-350	sterol carrier protein 2	Rattus norvegicus	44-78
31728857-8	2019	Further experiments verified that PF pretreatment alleviated H2O2-induced oxidative stress through increasing cell viability, inhibiting cell apoptosis, reducing ROS generation and activating JAK2/STAT3 and ERK1/2 pathways.	Water	61-65	Janus kinase 2	Mus musculus	192-196
31728857-11	2019	These results indicated that PF can alleviate H2O2-induced oxidative stress by down-regulation of miR-135a via activation of JAK2/STAT3 and ERK1/2 pathways.	Water	46-50	Janus kinase 2	Mus musculus	125-129
1623942-2	1992	A washed water-insoluble fraction from bovine, human and cataractous lens nuclei, when solubilized by sonication, gave specific activities of 910, 950 and 1270 U mg-1, respectively.	Water	9-14	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	162-166
31430731-6	2019	During 32 h of electrolysis, the results show that the current of our electrodes maintains 80% performance at a constant voltage of 1.7 V for 32 h, and the NiFeP/CoP/CC anodes and cathodes have large potential in industrial alkaline water splitting.	Water	233-238	caspase recruitment domain family member 16	Homo sapiens	162-165
1624955-5	1992	Analysis of the RGDS sequence conformational possibilities, as simulated in vacuum and in water solution, indicates that they can be classified into several conformational classes, which correspond roughly to the behaviour of the RGDS fragment as observed in protein matrices.	Water	90-95	ral guanine nucleotide dissociation stimulator	Homo sapiens	16-20
31783479-5	2019	Phosphoproteomic analysis showed that CeO2NPs reverted the H2O2-mediated increase in the phosphorylation of peptides related to cellular proliferation, stress response, and gene transcription regulation, and interfered with H2O2 effects on mTOR, MAPK/ERK, CK2A1 and PKACA signaling pathways.	Water	59-63	casein kinase 2 alpha 1	Homo sapiens	256-261
1761550-1	1991	Three explanations have been advanced to account for the unexpected absence of direct hydrogen bonds and presence of a buried water layer in the co-crystal-line complex of Escherichia coli trp repressor with DNA.	Water	126-131	repressor	Escherichia coli	193-202
1814758-4	1991	Enhanced sensitivity to IL-1-induced suppression of food and water intake were observed in obese yellow mice compared to lean mice (food intake suppression: lean 29.92%, obese 88.48%; water intake suppression: lean 25.18%, obese 71.56% of respective controls).	Water	61-66	interleukin 1 complex	Mus musculus	24-28
31445446-2	2019	Here, the intrinsically disordered protein alpha-synuclein is explored as a dispersant of single-walled carbon nanotubes (SWNTs) in water.	Water	132-137	synuclein alpha	Homo sapiens	43-58
1814758-4	1991	Enhanced sensitivity to IL-1-induced suppression of food and water intake were observed in obese yellow mice compared to lean mice (food intake suppression: lean 29.92%, obese 88.48%; water intake suppression: lean 25.18%, obese 71.56% of respective controls).	Water	184-189	interleukin 1 complex	Mus musculus	24-28
1726131-0	1991	Allosteric inhibition of the water-soluble C-terminal fragment of Sendai virus neuraminidase.	Water	29-34	neuraminidase 1	Homo sapiens	79-92
31526567-6	2019	Additionally, PRDX1-knockout mice showed reduced infarction area and alleviated neuropathological scores with decreased brain water contents.	Water	126-131	peroxiredoxin 1	Mus musculus	14-19
31530390-7	2019	Suppressing BRD4 by JQ1 reduced the infarction volume, brain water contents and neurological deficit score of MCAO mice.	Water	61-66	bromodomain containing 4	Mus musculus	12-16
1892828-1	1991	With standard one- and two-dimensional proton NMR techniques, a common structural motif has been identified in water solutions of short peptide sequences derived from the envelope glycoprotein gp120 of HIV-1.	Water	111-116	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	193-198
31515915-0	2019	alpha-Synuclein Spontaneously Adopts Stable and Reversible alpha-Helical Structure in Water-less Environment.	Water	86-91	synuclein alpha	Homo sapiens	0-15
31515915-1	2019	Highly stable, spontaneous and a reversible alpha-helical structure formation in recombinant and chemically modified alpha-synuclein protein is demonstrated for the first time in a water-less ~ O (1.5% w/w H 2 O) polymer surfactant environment.	Water	181-186	synuclein alpha	Homo sapiens	117-132
31515915-2	2019	Using a combination of circular dichroism and ATR-FTIR spectroscopy, we show that whilst native alpha-synuclein in aqueous solution shows a predominant unordered conformation (  64%), mixing with polyethylene glycol based anionic polymer surfactant (PS), and removing water reveals a 25% unordered, 25% alpha-helical, and 27% beta-sheet structure.	Water	268-273	synuclein alpha	Homo sapiens	96-111
31515915-3	2019	Interestingly, bioconjugation of native alpha-synuclein with a diamine molecule to increase the positive charge on the protein chain, and subsequently electrostatic coupling with PS forms a conjugate with a retained unordered structure, from which removal of water provides a highly stable alpha-helical (  74%) water-less liquid system.	Water	259-264	synuclein alpha	Homo sapiens	40-55
31515915-3	2019	Interestingly, bioconjugation of native alpha-synuclein with a diamine molecule to increase the positive charge on the protein chain, and subsequently electrostatic coupling with PS forms a conjugate with a retained unordered structure, from which removal of water provides a highly stable alpha-helical (  74%) water-less liquid system.	Water	312-317	synuclein alpha	Homo sapiens	40-55
1663709-9	1991	The catalytic rate constant for bovine Cu/Zn superoxide dismutase was determined to be 2.3 x 10(9) M-1 s-1 in H2O and D2O-based buffers and was independent of pH over the range 7-9.	Water	110-113	superoxide dismutase [Cu-Zn]	Bos taurus	39-65
1954333-4	1991	Aldose reductase activity in tubules dissected from kidneys of control rats and rats undergoing water diuresis was measured, and the tubules were permeabilized so that changes in intracellular composition that would occur during dehydration could be induced experimentally.	Water	96-101	aldo-keto reductase family 1 member B1	Rattus norvegicus	0-16
31694346-7	2019	Additionally, the exposure of human sperm to H2O2 resulted in a significant decrease in sperm viability and motility and an increase in the levels of HSF1, HSP90, HSP60, HSP27, and eIF2alpha; all proteins involved in sensing and response to unfolded proteins.	Water	45-49	heat shock protein 90 alpha family class A member 1	Homo sapiens	156-161
31694346-7	2019	Additionally, the exposure of human sperm to H2O2 resulted in a significant decrease in sperm viability and motility and an increase in the levels of HSF1, HSP90, HSP60, HSP27, and eIF2alpha; all proteins involved in sensing and response to unfolded proteins.	Water	45-49	heat shock protein family B (small) member 1	Homo sapiens	170-175
1654475-2	1991	Immersion of the hind paw of rats in water at 47 degrees C for 30 min led to a marked increase of immunoreactive CGRP (iCGRP) release as well as immunoreactive substance P release, but no detectable increase of immunoreactive neurokinin A release.	Water	37-42	calcitonin-related polypeptide alpha	Rattus norvegicus	113-117
31656733-6	2019	H2O2 facilitates the regulation of different stress-responsive transcription factors (TFs) including NAC, Zinc finger, WRKY, ERF, MYB, DREB and bZIP as both upstream and downstream events during stress signalling.	Water	0-4	MYB proto-oncogene, transcription factor	Homo sapiens	130-133
24221442-0	1991	Water-soluble proteins of mature barley endosperm: genetic control, polymorphism, and linkage with beta-amylase and spring/winter habit.	Water	0-5	1,4-alpha-D-glucan maltohydrolase	Hordeum vulgare	99-111
31509013-3	2019	Two Epac isoforms, Epac1 and Epac2, are abundantly expressed in the renal epithelium, where they are thought to regulate water and electrolyte transport, particularly in the proximal tubule and collecting duct.	Water	121-126	Rap guanine nucleotide exchange factor (GEF) 4	Mus musculus	29-34
31382050-7	2019	Here, the NAC part (i.e., alpha-syn(61-95)) responsible for the aggregation was found to change its unstructured conformation in aqueous solution to alpha-helix at the air-water interface by circular dichroism and MAIRS.	Water	172-177	synuclein alpha	Homo sapiens	26-35
1854946-2	1991	Calcitonin injection in the dose of 0.6 U/100 g of the body mass in NR and SHR in the conditions of 6-hour spontaneous diuresis caused the increase in the urination volume due to the inhibition of the tubular water reabsorption and growth of the glomerular filtration rate.	Water	209-214	calcitonin-related polypeptide alpha	Rattus norvegicus	0-10
31415924-5	2019	The treated water possessed low concentration of chlorophyll-a (0.3-0.6 mg L-1) and cell density (2 x 106-3 x 106 cell mL-1).	Water	12-17	L1 cell adhesion molecule	Mus musculus	75-78
31415924-5	2019	The treated water possessed low concentration of chlorophyll-a (0.3-0.6 mg L-1) and cell density (2 x 106-3 x 106 cell mL-1).	Water	12-17	L1 cell adhesion molecule	Mus musculus	119-123
2019683-3	1991	AChE activity is revealed by the Karnovsky &amp; Roots staining technique in the presence of propoxur, or after exposure of the membrane to paraoxon and rinsing with water.	Water	166-171	neuroligin-4, Y-linked	Musca domestica	0-4
31628420-3	2019	When mice received acidified drinking water (pH 2.5-2.9) instead of normal tap water (pH 8.4) for several generations, the motor skills of Cln3-/- mice normalized to control levels, indicating a disease-modifying effect of acidified water.	Water	38-43	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	139-143
2023866-4	1991	Using the dynamic method, water adsorption isotherms at 25 degrees C were also determined for four biologically active proteins: alpha-amylase, beta-glucuronidase, lipase, and urease.	Water	26-31	glucuronidase beta	Homo sapiens	144-162
31628420-4	2019	Here we investigated if acidified water administered from postnatal day 21 has therapeutic benefits in Cln3-/- mice.	Water	34-39	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	103-107
31628420-5	2019	Indeed, acidified water temporarily attenuated the motor deficits, had beneficial effects on behavioral parameters and prevented microglial activation in the brain of Cln3-/- mice.	Water	18-23	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	167-171
2054603-0	1991	Central nervous system action of endothelin-3 to inhibit water drinking in the rat.	Water	57-62	endothelin 3	Rattus norvegicus	33-45
31628420-7	2019	Since the gut microbiota can influence neurological functions, we examined it in our disease model and found that the gut microbiota of Cln3-/- mice was markedly different from control mice, and acidified water differentially changed the gut microbiota composition in these mice.	Water	205-210	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	136-140
31352494-6	2019	Opening CSF pressure was 6 cm H2O.	Water	30-33	colony stimulating factor 2	Homo sapiens	8-11
31535845-0	2019	Template-Directed Bifunctional Dodecahedral CoP/CN@MoS2 Electrocatalyst for High Efficient Water Splitting.	Water	91-96	caspase recruitment domain family member 16	Homo sapiens	44-47
2054603-1	1991	Endothelin-3, a vasoconstrictor peptide produced not only in endothelial cells but also within the brain interstitium in magnocellular neurons of the hypothalamo-neurohypophysial system, exerted significant, dose-related, inhibitory effects on water intake when administered into the third cerebroventricle of rats exposed to exogenous and endogenous stimuli for drinking.	Water	244-249	endothelin 3	Rattus norvegicus	0-12
2054603-2	1991	Passive immunoneutralization of endogenous endothelin-3 accentuated water drinking in response to angiotensin II administration suggesting a physiological role for the peptide in the central control of fluid and electrolyte homeostasis.	Water	68-73	endothelin 3	Rattus norvegicus	43-55
31555141-1	2019	Objective: Mitochondrial thioredoxin 2 (Trx2) is a vital mitochondrial redox protein that mediates normal protein thiol reduction and provides electrons to peroxiredoxin 3 (Prx3) to scavenge H2O2 in mitochondria.	Water	191-195	thioredoxin 2	Mus musculus	40-44
1663207-3	1991	Even the small (30.3%) and brief (45 min) reduction in fractional water excretion with the maximal (1 nM/kg/h) hPTH concentration was approximated by PTHrP.	Water	66-71	parathyroid hormone like hormone	Homo sapiens	150-155
31555141-1	2019	Objective: Mitochondrial thioredoxin 2 (Trx2) is a vital mitochondrial redox protein that mediates normal protein thiol reduction and provides electrons to peroxiredoxin 3 (Prx3) to scavenge H2O2 in mitochondria.	Water	191-195	peroxiredoxin 3	Mus musculus	156-171
31555141-1	2019	Objective: Mitochondrial thioredoxin 2 (Trx2) is a vital mitochondrial redox protein that mediates normal protein thiol reduction and provides electrons to peroxiredoxin 3 (Prx3) to scavenge H2O2 in mitochondria.	Water	191-195	peroxiredoxin 3	Mus musculus	173-177
31343153-0	2019	Constructing Bifunctional 3D Holey and Ultrathin CoP Nanosheets for Efficient Overall Water Splitting.	Water	86-91	caspase recruitment domain family member 16	Homo sapiens	49-52
31509399-4	2019	Zr(NaPO4)2 H2O crystallizes in the space group P21/c with cell parameters a = 8.7584(1) A, b = 5.3543(1) A, c = 18.1684(3) A, beta = 109.053 (1) , and Z = 4.	Water	11-14	H3 histone pseudogene 16	Homo sapiens	47-50
1663207-4	1991	It is concluded that the structural homology between hPTH and PTHrP allows a similar action on renal electrolyte transport, including the partial agonist effect of higher concentrations of PTH on vasopressin-induced water transport.	Water	216-221	parathyroid hormone like hormone	Homo sapiens	62-67
1688365-2	1990	Hypoalbuminemia and high circulating concentrations of alpha 2-macroglobulin were present after 48 h. Liver size, protein content, and protein fractional synthetic rate (FSR) were all increased, whereas loss of muscle protein occurred together with similar (45-50%) reductions in both intramuscular glutamine concentrations ([Gln]i, mmol/l intracellular water) and FSR.	Water	354-359	alpha-2-macroglobulin	Rattus norvegicus	55-76
31170603-5	2019	In addition, this proposed detection analysis has the direct application for monitoring Zn2+ and Cd2+ concentrations in tap and drinking water samples.	Water	137-142	CD2 molecule	Homo sapiens	97-100
31313572-4	2019	In this study, we developed a novel biomimetic water-swelling solid-phase microextraction (SPME) probe, with limits of detection for neonicotinoids as low as 0.03 ng mL-1, and applied it for in vivo detection of seven neonicotinoids in plant sap.	Water	47-52	L1 cell adhesion molecule	Mus musculus	166-170
31345036-1	2019	In this study, we characterized the structure and the dynamics at a picosecond scale of water molecules in aqueous solutions with cations having various kosmotropic properties (XCl2 where X = Ba2+, Ca2+, and Mg2+) confined in highly ordered mesoporous silica (MCM-41 and grafted MCM-41) by Fourier transform infrared spectroscopy and quasi-elastic neutron scattering.	Water	88-93	X-C motif chemokine ligand 2	Homo sapiens	177-181
31345036-3	2019	These results suggest that whatever the ions kosmotropic properties, for pore sizes phip &lt; 2.6 nm and [XCl2] &lt;= 1 M, the water dynamics is mainly slowed down by the size of the confinement.	Water	127-132	X-C motif chemokine ligand 2	Homo sapiens	106-110
2266018-0	1990	Gripe water: what is it?	Water	6-11	Ral GTPase activating protein catalytic subunit alpha 1	Homo sapiens	0-5
31313956-7	2019	The phosphoproteomic data were used to create a web resource for the investigation of G protein-coupled receptor signaling and regulation of AQP2-mediated water transport.	Water	155-160	aquaporin 2	Rattus norvegicus	141-145
31555385-4	2019	The aim of the present study was to investigate the effect of miR-370 on oxidative stress and apoptosis of cardiac myocytes in ischemic H9C2 cells induced by hydrogen peroxide (H2O2).	Water	177-181	microRNA 370	Rattus norvegicus	62-69
2147229-9	1990	These results provide the first evidence for the structural authenticity of a secreted water-soluble chimeric form of the variable region of a human TCR alpha chain.	Water	87-92	T cell receptor alpha constant	Homo sapiens	149-158
31555385-11	2019	The results revealed that miR-370 expression was downregulated and FOXO1 expression was increased in H9C2 cells induced by H2O2.	Water	123-127	microRNA 370	Rattus norvegicus	26-33
31555385-13	2019	The ELISA and flow cytometry assay revealed that miR-370 overexpression and FOXO1 silencing reversed H2O2-induced oxidative stress and apoptosis.	Water	101-105	microRNA 370	Rattus norvegicus	49-56
31555385-14	2019	The results indicated that miR-370 could inhibit the oxidative stress and apoptosis of H9C2 cells induced by H2O2 by targeting FOXO1.	Water	109-113	microRNA 370	Rattus norvegicus	27-34
31695405-0	2019	GPX2 suppression of H2O2 stress regulates cervical cancer metastasis and apoptosis via activation of the beta-catenin-WNT pathway.	Water	20-24	glutathione peroxidase 2	Homo sapiens	0-4
31695405-0	2019	GPX2 suppression of H2O2 stress regulates cervical cancer metastasis and apoptosis via activation of the beta-catenin-WNT pathway.	Water	20-24	catenin beta 1	Homo sapiens	105-117
2120080-3	1990	Accumulation of fluorescence was significantly reduced both in water soluble (P less than 0.001) and insoluble (P less than 0.005) lens fractions in galactosemic rats receiving the aldose reductase inhibitor sorbinil.	Water	63-68	aldo-keto reductase family 1 member B1	Rattus norvegicus	181-197
31152851-4	2019	The release of Gd3+ from these agents have been reported previously using experimental setups involving water, but this study evaluates the release in cell culture of dorsal root ganglion (DRG) neurons as this model system is relevant to neuronal toxicity induced by these agents.	Water	104-109	GRDX	Homo sapiens	15-18
31405001-7	2019	The data showed that additional prominent phenotypic features of jai1-1, such as diminished water content and pollen vitality, and accumulation of phenylpropanoids were at least partially rescued by the ET-insensitivity.	Water	92-97	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	65-71
31323530-3	2019	Using a transient middle cerebral artery occlusion (tMCAO) mouse model in this study, we found that intranasal Wnt-3a-treated tMCAO mice had apparently reduced infarct volume and decreased brain water content after being allowed to recover for 72 h, as well as better neurologic outcomes on days 3, 7, and 14.	Water	195-200	wingless-type MMTV integration site family, member 3A	Mus musculus	111-117
31323531-5	2019	MCPIP1 overexpression induced by MG132 alleviated sepsis-induced pathologic changes, water content and protein leakage in the lungs, and induction of systemic inflammatory mediators, and improved the 7-day mortality rate in the model rats.	Water	85-90	zinc finger CCCH type containing 12A	Rattus norvegicus	0-6
2142385-2	1990	The intra-abdominal hydrostatic pressure (Pih) given in cm H2O is the height of the meniscus of a column of water above the anterior abdominal wall measured with the patient supine.	Water	59-62	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	42-45
31432150-9	2019	These results suggest that a hypotonic solution at low temperature increased initial water influx via activation of AQP5 and decreased Cl- efflux via inhibition of LRRC8A.	Water	85-90	aquaporin 5	Homo sapiens	116-120
31447686-1	2019	Arginine vasopressin (AVP) mediates water reabsorption in the kidney collecting ducts through regulation of aquaporin-2 (AQP2).	Water	36-41	aquaporin 2	Rattus norvegicus	121-125
2142385-2	1990	The intra-abdominal hydrostatic pressure (Pih) given in cm H2O is the height of the meniscus of a column of water above the anterior abdominal wall measured with the patient supine.	Water	108-113	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	42-45
31382467-2	2019	In this study, we investigated the mechanism underlying the onset of diabetic xeroderma, focusing on aquaporin-3 (AQP3), which plays an important role in water transport in the skin.	Water	154-159	aquaporin 3 (Gill blood group)	Homo sapiens	114-118
31141217-4	2019	The two inhibitor-bound structures reveal that Ser52, a nonconserved residue in the ATP binding pocket in Hsp90alpha, provides additional stability to PU-11-trans through a water-mediated hydrogen-bonding network.	Water	173-178	heat shock protein 90 alpha family class A member 1	Homo sapiens	106-116
2142385-4	1990	In 23 study subjects, Pih measured 7.0 +/- 4.8 cm H2O; Pih correlated inversely with all static volumes.	Water	50-53	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	22-25
32830717-3	2019	Interestingly, X-ray analyses reveal two distinct groups of complexes: reactions with LH only lead to tetrahedral or quasi-tetrahedral complexes {i.e. [CoCl2(LH)2] (1), [CoI2(LH)2] (2), [Co(NO3)2(LH)2] (3), [Co(NCS)2(LH)2] (4)}, whereas L"H favours octahedral coordination {i.e. [Co(L"H)4(MeCN)(H2O)]I2 (5), [Co(L"H)4(MeCN)(H2O)](NO3)2 (6) and [Co(NCS)2(L"H)4)] 2MeOH (7 2MeOH)}.	Water	295-298	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	86-88
2354450-8	1990	Body composition studies of rats that completed the 8 days of treatment indicate that rats receiving either continuous infusion or intermittent bolus TNF have increased percentages of body water and reduced percentages of body solid compared to saline treated control rats.	Water	189-194	tumor necrosis factor-like	Rattus norvegicus	150-153
32830717-3	2019	Interestingly, X-ray analyses reveal two distinct groups of complexes: reactions with LH only lead to tetrahedral or quasi-tetrahedral complexes {i.e. [CoCl2(LH)2] (1), [CoI2(LH)2] (2), [Co(NO3)2(LH)2] (3), [Co(NCS)2(LH)2] (4)}, whereas L"H favours octahedral coordination {i.e. [Co(L"H)4(MeCN)(H2O)]I2 (5), [Co(L"H)4(MeCN)(H2O)](NO3)2 (6) and [Co(NCS)2(L"H)4)] 2MeOH (7 2MeOH)}.	Water	324-327	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	86-88
31229063-6	2019	PC3 powder presented a homogeneous aspect with a mean particle size of 86.39 mum, high water solubility (&gt;92%) in a wide pH range (1-12) and an increase of 33% in oil absorption capacity, when compared to the unhydrolyzed product.	Water	87-92	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	0-3
31254881-8	2019	The study also showed that water chemistry parameters, such as pH and salinity, can affect DBP formation by changing the adsorption of NOM onto CMs.	Water	27-32	ethylene-responsive transcription factor ERF008	Triticum aestivum	91-94
2354450-9	1990	Rats pair fed to the food intake of continuous TNF treated rats also had increased percentages of body water and reduced percentages of body solid, but changes were significantly less than those observed in continuous TNF infused rats.	Water	103-108	tumor necrosis factor-like	Rattus norvegicus	47-50
2354450-12	1990	Twice a day administration of TNF resulted in lesser changes in carcass water, solid, nitrogen, lipid, and potassium than continuous infusion of the same dose of TNF.	Water	72-77	tumor necrosis factor-like	Rattus norvegicus	30-33
31266303-5	2019	Control and mechanistic investigations reveal that HCN formed during laser irradiation reacts rapidly to reduce the Cu(II) centers in [Cu(OAc)2]2, leading to the formation of CuCN or, in the presence of water, Cu2O nanoparticles that bind and cross-link CuCN-polyacetonitrile chains.	Water	203-208	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	51-54
2129508-8	1990	Thus, there is coordinated regulation of aldose reductase and sorbitol dehydrogenase activities so that (a) during water diuresis, aldose reductase activity decreases while sorbitol dehydrogenase activity increases; and (b) during antidiuresis (water restriction and/or vasopressin administration), aldose reductase activity increases while sorbitol dehydrogenase activity remains low.	Water	115-120	aldo-keto reductase family 1 member B1	Rattus norvegicus	41-57
31374984-4	2019	The Xenopus laevis oocyte expression system was used to study the effect of Rg3 epimers on the AQP1 water permeability.	Water	100-105	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	95-99
32309614-5	2019	After two weeks of treatment with doxycycline in drinking water, a subset of treated shRNA Rpl5+/- adult mice developed mild anemia while control mice had normal complete blood counts.	Water	58-63	ribosomal protein L5	Mus musculus	91-95
31576091-0	2019	High mobility group box-1 release from H2O2-injured hepatocytes due to sirt1 functional inhibition.	Water	39-43	sirtuin 1	Mus musculus	71-76
2129508-8	1990	Thus, there is coordinated regulation of aldose reductase and sorbitol dehydrogenase activities so that (a) during water diuresis, aldose reductase activity decreases while sorbitol dehydrogenase activity increases; and (b) during antidiuresis (water restriction and/or vasopressin administration), aldose reductase activity increases while sorbitol dehydrogenase activity remains low.	Water	115-120	sorbitol dehydrogenase	Rattus norvegicus	62-84
2129508-8	1990	Thus, there is coordinated regulation of aldose reductase and sorbitol dehydrogenase activities so that (a) during water diuresis, aldose reductase activity decreases while sorbitol dehydrogenase activity increases; and (b) during antidiuresis (water restriction and/or vasopressin administration), aldose reductase activity increases while sorbitol dehydrogenase activity remains low.	Water	245-250	aldo-keto reductase family 1 member B1	Rattus norvegicus	41-57
2129508-8	1990	Thus, there is coordinated regulation of aldose reductase and sorbitol dehydrogenase activities so that (a) during water diuresis, aldose reductase activity decreases while sorbitol dehydrogenase activity increases; and (b) during antidiuresis (water restriction and/or vasopressin administration), aldose reductase activity increases while sorbitol dehydrogenase activity remains low.	Water	245-250	sorbitol dehydrogenase	Rattus norvegicus	62-84
31562333-3	2019	While H2O2 exposure substantially decreases cell proliferation and increases p53, p21, p16, and p19 in cells from mice and rats, cells from spiny mice and rabbits are highly resistant to H2O2.	Water	6-10	transformation related protein 53, pseudogene	Mus musculus	77-80
31036196-6	2019	Upon application on environmental water samples, the two ZnO-NPs, NP-A and NP-B, have been separated and size characterized.	Water	34-39	neuropeptide B	Homo sapiens	75-79
1966965-3	1990	Fortunately, the changes in 1/T1 and 1/T2 of water protons in solution--and ultimately in tissue--induced by these agents arise from variations of only a few physical parameters.	Water	45-50	interleukin 1 receptor like 1	Homo sapiens	30-38
31179685-3	2019	This contribution addresses the interaction of a NSF of water/propylene carbonate containing a nonionic surfactant with an acrylic polymer film commonly used in art conservation.	Water	56-61	artemin	Homo sapiens	161-164
31547514-8	2019	Therefore, this combination of solid phase micro membrane tip extraction and capillary electrophoresis may be considered as the ideal one for monitoring of toxic phenol and p-amino-phenol in water sample.	Water	191-196	TOR signaling pathway regulator	Homo sapiens	58-61
33774246-6	2021	Besides, the PCA indicated that TN, NO3--N and DO were important factors, which affected the water quality of CW.	Water	93-98	C-type lectin domain family 3 member B	Homo sapiens	32-34
31487173-0	2019	Water Solubility and Surface Property of Alkyl Di-/Tri-/Tetraoxyethyl beta-d-Xylopyranosides.	Water	0-5	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	51-54
31388578-1	2019	The mechanism of the (CH3)2CCH2+H2O (CH3)3COH reaction catalyzed by two strong acids (H2SO4 and HSbF6) was investigated theoretically using the ab initio MP2 and CCSD(T) methods and the aug-cc-pVDZ/LANL2DZ and aug-cc-pVTZ/LANL2DZ basis sets.	Water	32-35	tryptase pseudogene 1	Homo sapiens	154-157
33824405-7	2021	The present multifaceted experimental study, complemented by homology modelling and molecular dynamics simulations, resolves a long-standing controversy about the taste of heavy water, shows that its sweet taste is mediated by the human TAS1R2/TAS1R3 taste receptor, and opens way to future studies of the detailed mechanism of action.	Water	178-183	taste 1 receptor member 3	Homo sapiens	244-250
31339916-0	2019	Quantitative proteomics reveals TMOD1-related proteins associated with water balance regulation.	Water	71-76	tropomodulin 1	Mus musculus	32-37
31339916-11	2019	Our study provides valuable information on the molecular functions and the regulatory network of Tmod1 gene in kidney, as well as the new mechanisms for the regulation of water balance.	Water	171-176	tropomodulin 1	Mus musculus	97-102
31087519-6	2019	The design of Co-MoS2 /CdS sheds light on the development of highly efficient low-cost photocatalysts for solar H2 generation from water reduction.	Water	131-136	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
31181306-0	2019	The use of zein in the controlled release of poorly water-soluble drugs.	Water	52-57	zein	Zea mays	11-15
31361476-0	2019	Electrochemical Tip-Enhanced Raman Spectroscopy with Improved Sensitivity Enabled by a Water Immersion Objective.	Water	87-92	TOR signaling pathway regulator	Homo sapiens	16-19
31389701-3	2019	Herein, we describe a thermoswitchable oil-in-water (O/W) particle-stabilized emulsion that exhibits improved stability due to the addition of cellulose nanocrystals (CNCs) modified with poly[2-isopropoxy-2-oxo-1,3,2-dioxaphospholane] (PIPP), which exhibits relatively good biocompatibility and biodegradability.	Water	46-51	inositol polyphosphate-5-phosphatase J	Homo sapiens	236-240
31389701-6	2019	Heptane-in-water particle-stabilized emulsions with CNC-g-PIPP were stably formed, and the effect of temperature on the stability of the emulsions was characterized.	Water	11-16	inositol polyphosphate-5-phosphatase J	Homo sapiens	52-62
31389701-7	2019	CNC-g-PIPP exhibited function as an effective particulate emulsifier at 4  C because of the strong adsorption at the oil-water interface.	Water	121-126	inositol polyphosphate-5-phosphatase J	Homo sapiens	0-10
31181306-2	2019	Recent remarkable investigations on the use of zein in controlled drug delivery have contributed both important knowledge and potential applications of various products, particularly in the delivery of poorly water-soluble drugs.	Water	209-214	zein	Zea mays	47-51
33794341-1	2021	Water transport in the brain is tightly controlled by blood-brain-barrier (BBB) composed of capillary endothelial cells expressing AQP1/AQP11 and glial foot processes expressing AQP4.	Water	0-5	aquaporin 1	Mus musculus	131-135
31396333-8	2019	This mechanism induces an interaction with sirtuin 1 (SIRT1)/p53 pathway suggesting a link between ghrelin and SIRT1 in the regulation of salt and water metabolism.	Water	147-152	sirtuin 1	Mus musculus	43-52
31396333-8	2019	This mechanism induces an interaction with sirtuin 1 (SIRT1)/p53 pathway suggesting a link between ghrelin and SIRT1 in the regulation of salt and water metabolism.	Water	147-152	sirtuin 1	Mus musculus	54-59
31396333-8	2019	This mechanism induces an interaction with sirtuin 1 (SIRT1)/p53 pathway suggesting a link between ghrelin and SIRT1 in the regulation of salt and water metabolism.	Water	147-152	transformation related protein 53, pseudogene	Mus musculus	61-64
31396333-8	2019	This mechanism induces an interaction with sirtuin 1 (SIRT1)/p53 pathway suggesting a link between ghrelin and SIRT1 in the regulation of salt and water metabolism.	Water	147-152	sirtuin 1	Mus musculus	111-116
31396333-12	2019	Water movement across biological cell membranes is enhanced or facilitated by tetrameric membrane-bound channels, named aquaporin (AQP) family, and in particular, AQP1 and AQP2 proteins.	Water	0-5	aquaporin 2	Mus musculus	172-176
31389701-8	2019	However, the emulsions rapidly disintegrated at 45  C, which is above the low critical solution temperature of PIPP on CNC, as the hydrophobized CNC-g-PIPP desorbed from the oil-water interface.	Water	178-183	inositol polyphosphate-5-phosphatase J	Homo sapiens	145-155
33778193-9	2021	SAMs-OH showed poor Fn adsorption as the water film.	Water	41-46	methionine adenosyltransferase 1A	Homo sapiens	0-4
31387178-6	2019	Furthermore, CFLAR knockdown markedly elevated the neurological deficit, brain water content and the infarct volume.	Water	79-84	CASP8 and FADD-like apoptosis regulator	Mus musculus	13-18
33591185-1	2021	In addition to its vital significance in combustion and atmospheric chemistry, the reaction between H" and HO2 on the ground triplet state represents a prototype with multiple product channels, including H2 + O2, OH + OH, O + H2O, and H + H"O2.	Water	226-229	heme oxygenase 2	Homo sapiens	107-110
31158673-9	2019	According to the principle component analysis and redundancy analysis, water samples collected from the sea clustered together while those from the coastal zone and rivers were separated.	Water	71-76	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	104-107
31003120-6	2019	These results indicate that GH may be an efficient adsorbent for antibiotic pollutants removal in water purification.	Water	98-103	gamma-glutamyl hydrolase	Homo sapiens	28-30
32795718-0	2020	Rapid oxidation of histamine H2-receptor antagonists by peroxymonosulfate during water treatment: Kinetics, products, and toxicity evaluation.	Water	81-86	histamine receptor H2	Homo sapiens	19-40
31280283-8	2019	The mechanism of HSVP in regulating intestinal water metabolism in constipated rats may occur through the VIP-cAMP-PKA-AQP3 signaling pathway, and be closely related to changes in intestinal bacteria.	Water	47-52	aquaporin 3 (Gill blood group)	Rattus norvegicus	119-123
31277235-5	2019	Here, we report that, in addition to its established water permeation capacity, human AQP5 facilitates transmembrane H2O2 diffusion and modulates cell growth of AQP5-transformed yeast cells in response to oxidative stress.	Water	53-58	aquaporin 5	Homo sapiens	86-90
29580169-6	2019	The configuration named route 3, composed of MF of raw landfill leachate (MF1), POA-Fenton-MF2 of the MF1 concentrate and NF of both MF1 and MF2 permeates, showed a higher global water recovery and was responsible for lower waste generation.	Water	179-184	flap structure-specific endonuclease 1	Homo sapiens	74-77
29580169-6	2019	The configuration named route 3, composed of MF of raw landfill leachate (MF1), POA-Fenton-MF2 of the MF1 concentrate and NF of both MF1 and MF2 permeates, showed a higher global water recovery and was responsible for lower waste generation.	Water	179-184	flap structure-specific endonuclease 1	Homo sapiens	102-105
29580169-6	2019	The configuration named route 3, composed of MF of raw landfill leachate (MF1), POA-Fenton-MF2 of the MF1 concentrate and NF of both MF1 and MF2 permeates, showed a higher global water recovery and was responsible for lower waste generation.	Water	179-184	flap structure-specific endonuclease 1	Homo sapiens	102-105
30862095-3	2019	Furthermore, the quasi-water-cement ratio is introduced to predict the strength of the DGSC-solidified soil.	Water	23-28	DiGeorge syndrome critical region gene 2	Homo sapiens	87-91
31039415-9	2019	MTX produced alterations on water handling on the second day after treatment, showing a significant increase in solute free water reabsorption which might be mediated by the increased expression of AQP2 in apical membranes.	Water	28-33	aquaporin 2	Rattus norvegicus	198-202
31039415-9	2019	MTX produced alterations on water handling on the second day after treatment, showing a significant increase in solute free water reabsorption which might be mediated by the increased expression of AQP2 in apical membranes.	Water	124-129	aquaporin 2	Rattus norvegicus	198-202
31152860-8	2019	Our results showed that IFNbeta treatment reduced APP expression and Abeta plaque formation, and concomitantly ameliorated spatial learning and memory deficits examined in Y-maze and Morris water maze tests.	Water	190-195	interferon beta 1	Rattus norvegicus	24-31
31081563-0	2019	Unveiling the Mechanisms of Aquaglyceroporin-3 Water and Glycerol Permeation by Metadynamics.	Water	47-52	aquaporin 3 (Gill blood group)	Homo sapiens	28-46
31081563-1	2019	Water and glycerol permeation through human AQP3 are described by exploiting advanced metadynamics approaches, which enabled both to explore the free energies involved in pore permeation and to achieve a description of the mechanisms with an atomistic level of detail.	Water	0-5	aquaporin 3 (Gill blood group)	Homo sapiens	44-48
30964709-3	2019	Chow-fed 17-wk-old female Apoe-/- mice treated with 4-PBA-supplemented drinking water for 5 wk exhibited smaller lesions as well as increased plasma levels of heat shock protein (HSP) 25, the mouse homolog of human HSP27, compared with controls.	Water	80-85	heat shock protein family B (small) member 1	Homo sapiens	215-220
30862095-6	2019	When the water-binder ratio of the DGSC-solidified soil is the same as that of the cement-solidified soil, after a28-day curing period, the content of DGSC is higher than that of the 5% cement content, so the DGSC solidification effect is comparable to that of cement.	Water	9-14	DiGeorge syndrome critical region gene 2	Homo sapiens	35-39
30923833-2	2019	We and others have previously demonstrated that exposure to copper through drinking water significantly increased parenchymal amyloid-beta (Abeta) plaques and decreased endothelial low-density lipoprotein receptor-related protein 1 (LRP1) in mouse models of AD.	Water	84-89	amyloid beta (A4) precursor protein	Mus musculus	140-145
30862095-6	2019	When the water-binder ratio of the DGSC-solidified soil is the same as that of the cement-solidified soil, after a28-day curing period, the content of DGSC is higher than that of the 5% cement content, so the DGSC solidification effect is comparable to that of cement.	Water	9-14	DiGeorge syndrome critical region gene 2	Homo sapiens	151-155
30862095-6	2019	When the water-binder ratio of the DGSC-solidified soil is the same as that of the cement-solidified soil, after a28-day curing period, the content of DGSC is higher than that of the 5% cement content, so the DGSC solidification effect is comparable to that of cement.	Water	9-14	DiGeorge syndrome critical region gene 2	Homo sapiens	151-155
19379800-4	2009	Dehydration to 28% of total body water lost triggered organ-specific changes in nrf2 mRNA expression (a 2-fold increase in liver), total Nrf2 protein (2-4-fold elevation in lung, heart, skin and liver), and a 4.3-fold increase in the content of Nrf2 in the nucleus in muscle.	Water	33-38	GA binding protein transcription factor subunit alpha S homeolog	Xenopus laevis	80-84
31182582-8	2019	Most importantly, in the reconstructed temperature-pressure (T-P) phase diagram of water, the EMT ice is located at deeply negative pressure regions below ice XVI and at higher temperature regions next to FAU.	Water	83-88	IL2 inducible T cell kinase	Homo sapiens	94-97
31443720-2	2019	As a recently we developed water-soluble pyridone agent with antifibrotic features, fluorofenidone (AKF-PD) can attenuate liver fibrosis, present studies were designed to explore the role of GSTA3 in liver fibrosis and its modulation by AKF-PD in vivo and in vitro.	Water	27-32	glutathione S-transferase alpha 3	Rattus norvegicus	191-196
30821219-2	2019	Aquaporin 4 (AQP4) regulates water content in blood, brain, and cerebrospinal fluid.	Water	29-34	aquaporin 4	Rattus norvegicus	0-11
34848886-10	2022	The effect of viral binding to neuronal ACE2 in areas of the brain that regulate salt/water balance and blood pressure is also discussed in light of the neural regulation of hypertension in COVID-19.	Water	86-91	angiotensin converting enzyme 2	Homo sapiens	40-44
30821219-2	2019	Aquaporin 4 (AQP4) regulates water content in blood, brain, and cerebrospinal fluid.	Water	29-34	aquaporin 4	Rattus norvegicus	13-17
31233537-4	2019	When mobilized by the Arabidopsis thaliana beta-glucosidase 1 (AtBG1), the glucose ester-conjugated inactive form of ABA has proven to be a source of the active hormone that is essential for the adaptation of the plant to water deficit, as evidenced by the impaired stomatal closure of atbg1 mutants in response to water stress.	Water	222-227	beta-1,3-glucanase 1	Arabidopsis thaliana	63-68
31233537-4	2019	When mobilized by the Arabidopsis thaliana beta-glucosidase 1 (AtBG1), the glucose ester-conjugated inactive form of ABA has proven to be a source of the active hormone that is essential for the adaptation of the plant to water deficit, as evidenced by the impaired stomatal closure of atbg1 mutants in response to water stress.	Water	315-320	beta-1,3-glucanase 1	Arabidopsis thaliana	63-68
31153818-0	2019	Obestatin ameliorates water retention in chronic heart failure by downregulating renal aquaporin 2 through GPR39, V2R and PPARG signaling.	Water	22-27	aquaporin 2	Rattus norvegicus	87-98
34808123-12	2022	4) Mice with MALAT1 inhibition exhibited worse behavioral performances (NSS, wire grip, Morris water maze), as compared to control.	Water	95-100	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	13-19
31169845-3	2019	In this study, the capacity of an ethyl acetate : hexane extract (CPE/hexane) and water extract (CPE/water) to modulate the cell cycle re-entry of quiescent (PC-3 and LNCaP) prostate cancer cells was tested in an in vitro culture system.	Water	82-87	carboxypeptidase E	Homo sapiens	97-100
31169845-4	2019	Cell cycle analysis showed that the quiescent PC-3 and LNCaP cancer cells in the presence of CPE/water were impaired in their ability to enter the S phase where only 2-3% reduction of G0/G1 cells was noted compared to 12-18% reduction of control cells.	Water	97-102	carboxypeptidase E	Homo sapiens	93-96
31318210-0	2019	Redox Potentials of Small Inorganic Radicals and Hexa-Aquo Complexes of First-Row Transition Metals in Water: A DFT Study Based on the Grand Canonical Ensemble.	Water	103-108	hexosaminidase subunit alpha	Homo sapiens	49-53
34856348-2	2022	A film of CS-SA unidirectional release drug-containing water-repellent layer EC was produced by interfacial reaction solvent-drying technique using self-made equipment.	Water	55-60	citrate synthase	Homo sapiens	10-12
31368470-5	2019	Benefitting from the effective protection of robust glass, Mn-doped CsPb(Cl/Br)3 quantum dots exhibit superior water resistance and thermal stability.	Water	111-116	granzyme B	Homo sapiens	68-72
31385580-0	2019	Water-soluble chiral CdSe/CdS dot/rod nanocrystals for two-photon fluorescence lifetime imaging and photodynamic therapy.	Water	0-5	CDP-diacylglycerol synthase 1	Homo sapiens	21-24
31385580-7	2019	The performed investigation of the optical properties of these water-soluble CdSe/CdS dot/rod NCs indicates that they are promising candidates for nonlinear biological imaging applications.	Water	63-68	CDP-diacylglycerol synthase 1	Homo sapiens	77-80
31135144-6	2019	As a demonstration, we evaluate the nanowire as a sequestrating material capable of collecting toxic cations, like Cd2+, from water and photoreducing them (immobilizing them tightly).	Water	126-131	CD2 molecule	Homo sapiens	115-118
34837421-5	2022	The indoor bioaerosol community, significantly associated with the humidifier water, was substantially distorted after humidification and dominated by the pathogenic Pseudomonas spp.	Water	78-83	histocompatibility minor 13	Homo sapiens	178-181
30722875-1	2019	This study aims to prepare water-soluble beta-1,3-glucan (WSG) by hydrolysis of curdlan with H2O2.	Water	27-32	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	41-49
30925435-0	2019	Mask-less preparation of Janus particles through ultraviolet irradiation on hydrophobic particles assembled at the air-water interface.	Water	119-124	ankyrin repeat and KH domain containing 1	Homo sapiens	0-4
31358628-9	2019	A variety of experiments and polarization transfer from water and mobile side chains indicate that 0N4R tau fibrils exhibit heterogeneous dynamics: Outside the rigid R2-R3 core, the R1 and R4 repeats are semirigid even though they exhibit beta-strand character and the proline-rich domains undergo large-amplitude anisotropic motions, whereas the two termini are nearly isotropically flexible.	Water	56-61	microtubule associated protein tau	Homo sapiens	104-107
31399090-0	2019	Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat.	Water	0-5	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	43-48
34624580-6	2022	The average occurrence-weighted variations of standard values (i.e., numerical values provided in a standard in terms of residue limits of a given pesticide in water) for the 20 most regulated persistent organic pollutants (POPs) and other phase-out pesticides (i.e., pesticides not currently-approved for use in agriculture across various countries) are 4.1 and 2.6 orders of magnitude, respectively, with human-exposure related standard values for some pesticides varying with over 3 orders of magnitude (e.g., lindane).	Water	160-165	VPS52 subunit of GARP complex	Homo sapiens	351-364
31201535-7	2019	All of this indicates that UiO-66 is promising for simultaneous detection and the removal of CLB in water.	Water	100-105	citramalyl-CoA lyase	Homo sapiens	93-96
34990985-5	2022	The enzyme peroxiredoxin 6 (Prx6) belongs to the peroxiredoxin family, catalyses hydrogen peroxide (H2O2) into water (H2O).	Water	111-116	peroxiredoxin 6	Homo sapiens	11-26
31258460-2	2019	Aquaporin 4 (AQP4) is the most ubiquitous water channel in the central nervous system (CNS), which is a rate-limiting factor in vasogenic edema expressing in brain injury, and it contributes to the formation of cytotoxic edema locating in astrocytes.	Water	42-47	aquaporin 4	Rattus norvegicus	0-11
31258460-2	2019	Aquaporin 4 (AQP4) is the most ubiquitous water channel in the central nervous system (CNS), which is a rate-limiting factor in vasogenic edema expressing in brain injury, and it contributes to the formation of cytotoxic edema locating in astrocytes.	Water	42-47	aquaporin 4	Rattus norvegicus	13-17
31258460-9	2019	Firstly, we observe that the tissue water content increases after SCC and decreases after the peak value of tissue water content at 3 days (P &lt; 0.05) with abundant expression of AQP4 protein locating around vascular endothelial cells (VECs), which suggests that the increasing AQP4 promotes water reabsorption and improves vasogenic edema in the early stage of SCC.	Water	36-41	aquaporin 4	Rattus norvegicus	181-185
31258460-9	2019	Firstly, we observe that the tissue water content increases after SCC and decreases after the peak value of tissue water content at 3 days (P &lt; 0.05) with abundant expression of AQP4 protein locating around vascular endothelial cells (VECs), which suggests that the increasing AQP4 promotes water reabsorption and improves vasogenic edema in the early stage of SCC.	Water	36-41	aquaporin 4	Rattus norvegicus	280-284
31399090-0	2019	Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat.	Water	0-5	FBJ osteosarcoma oncogene	Mus musculus	115-120
31440136-6	2019	The effect of LPS on intestinal barrier function was investigated in vitro using intestinal epithelial (IEC-6) cells, and in vivo via administration of LPS in drinking water to Thy1-alphaSyn mice.	Water	168-173	synuclein, alpha	Mus musculus	182-190
34990985-5	2022	The enzyme peroxiredoxin 6 (Prx6) belongs to the peroxiredoxin family, catalyses hydrogen peroxide (H2O2) into water (H2O).	Water	111-116	peroxiredoxin 6	Homo sapiens	49-62
34990985-5	2022	The enzyme peroxiredoxin 6 (Prx6) belongs to the peroxiredoxin family, catalyses hydrogen peroxide (H2O2) into water (H2O).	Water	118-121	peroxiredoxin 6	Homo sapiens	11-26
34990985-5	2022	The enzyme peroxiredoxin 6 (Prx6) belongs to the peroxiredoxin family, catalyses hydrogen peroxide (H2O2) into water (H2O).	Water	118-121	peroxiredoxin 6	Homo sapiens	49-62
31185935-2	2019	Aquaporin (AQP) 1 and AQP2, important proteins for renal water reabsorption, have been identified in urinary extracellular vesicles (uEV-AQP1 and -AQP2), and experimental studies have shown that the presence of uEV-AQP1 and -AQP2 may be an indicator of their levels of expression in the kidney.	Water	57-62	aquaporin 2	Homo sapiens	22-26
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	238-248
31117367-9	2019	This discovery of ELP cononsolvency in water/alcohol systems introduces a new handle with which the solubility of ELPs can be tuned.	Water	39-44	nuclear receptor subfamily 5 group A member 1	Homo sapiens	18-21
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	260-264
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	779-783
30903871-4	2019	The as-synthesized CdS QDs/NMPPY hybrid shows a bright emission at 459 nm under excitation at 367 nm in water.	Water	104-109	CDP-diacylglycerol synthase 1	Homo sapiens	19-22
34256224-2	2021	A novel water-soluble chitosan (CS)-based copolymer was prepared to be used as a carrier to provide a pH-stable environment for loading PC.	Water	8-13	citrate synthase	Homo sapiens	32-34
30903871-9	2019	Finally, the proposed CdS QDs/NMPPY sensor was successfully utilized to determine the amount of picric acid in real water samples.	Water	116-121	CDP-diacylglycerol synthase 1	Homo sapiens	22-25
34966769-9	2021	Correspondingly, the daily records also showed that CSP-1 promoted recovery of diarrhea status score, water intake and body weight in mice with AAD.	Water	102-107	regulator of calcineurin 1	Mus musculus	52-57
31020528-1	2019	Adsorption plays an important role in removing cadmium (Cd2+) from water, and magnetic adsorbents are increasingly being used due to their ease of separation and recovery.	Water	67-72	CD2 molecule	Homo sapiens	56-59
34941853-2	2021	To protect the cells from oxidative damage, the Superoxide dismutase-1 (SOD1) degraded the hydrogen peroxide (H2O2) to oxygen (O2) and water.	Water	135-140	superoxide dismutase [Cu-Zn]	Bos taurus	48-70
34941853-2	2021	To protect the cells from oxidative damage, the Superoxide dismutase-1 (SOD1) degraded the hydrogen peroxide (H2O2) to oxygen (O2) and water.	Water	135-140	superoxide dismutase [Cu-Zn]	Bos taurus	72-76
34057015-7	2021	However, with the injection of IL-5, the degree of lung tissue injury in CLP rats was alleviated and the water content of lung tissue was significantly reduced.	Water	105-110	interleukin 5	Rattus norvegicus	31-35
34481371-5	2021	Results showed that the annual water yield increased by 20.20% in 2000-2015 and decreased by 33.92% in 2015-2018 affected by precipitation and land use changes; Changsha-Zhuzhou- Xiangtan urban agglomeration (CZX) and Southwest of Yongzhou were the high value areas of water yield (>338 m3/hm2).	Water	31-36	cholinergic receptor muscarinic 2	Homo sapiens	290-293
34481371-5	2021	Results showed that the annual water yield increased by 20.20% in 2000-2015 and decreased by 33.92% in 2015-2018 affected by precipitation and land use changes; Changsha-Zhuzhou- Xiangtan urban agglomeration (CZX) and Southwest of Yongzhou were the high value areas of water yield (>338 m3/hm2).	Water	269-274	cholinergic receptor muscarinic 2	Homo sapiens	290-293
34481371-6	2021	Due to the urban expansion, the water demand increased by 40.50% from 2000 to 2005 and decreased by 36.39% after 2005; From 2000 to 2018, high value areas of water demand (>53566 m3/hm2) mainly appeared in midstream and downstream with high urbanization level, dense population and developed industry.	Water	32-37	cholinergic receptor muscarinic 2	Homo sapiens	182-185
34481371-6	2021	Due to the urban expansion, the water demand increased by 40.50% from 2000 to 2005 and decreased by 36.39% after 2005; From 2000 to 2018, high value areas of water demand (>53566 m3/hm2) mainly appeared in midstream and downstream with high urbanization level, dense population and developed industry.	Water	158-163	cholinergic receptor muscarinic 2	Homo sapiens	182-185
34700041-5	2021	Taking advantage of fast hydrogen exchange (HX) between H2O2 and water permits the use of very short interscan delays, greatly increasing sensitivity.	Water	65-70	hemopexin	Homo sapiens	44-46
34700041-6	2021	The specific acid-, base- and water-catalyzed HX rates at 2  C were measured to be 2.1 x 107, 6.1 x 109, and 1.4 x 10-1 M-1s-1, respectively, which result in a minimum HX rate at pH 6.2.	Water	30-35	hemopexin	Homo sapiens	46-48
34700041-6	2021	The specific acid-, base- and water-catalyzed HX rates at 2  C were measured to be 2.1 x 107, 6.1 x 109, and 1.4 x 10-1 M-1s-1, respectively, which result in a minimum HX rate at pH 6.2.	Water	30-35	hemopexin	Homo sapiens	168-170
34255392-0	2021	Regularized joint water-fat separation with B0 map estimation in image space for 2D-navigated interleaved EPI based diffusion MRI.	Water	18-23	tissue factor pathway inhibitor	Homo sapiens	106-109
34255392-1	2021	PURPOSE: To develop a new water-fat separation and B0 estimation algorithm to effectively suppress the multiple resonances of fat signal in EPI.	Water	26-31	tissue factor pathway inhibitor	Homo sapiens	140-143
34255392-5	2021	This work proposes a suitable model approximation for EPI under B0 and fat off-resonance effects, providing a feasible multi-peak water-fat separation algorithm.	Water	130-135	tissue factor pathway inhibitor	Homo sapiens	54-57
34896810-2	2021	The production of biologically stable drinking water is challenging for conventional surface water treatment plants using reservoirs as feed water due to the presence of slowly biodegradable particulate and high-molecular weight biopolymeric organic carbon (high-MW OC) which increases the Microbial Growth Potential (MGP) in the feed water and produced drinking water.	Water	47-52	matrix Gla protein	Homo sapiens	290-316
34896810-2	2021	The production of biologically stable drinking water is challenging for conventional surface water treatment plants using reservoirs as feed water due to the presence of slowly biodegradable particulate and high-molecular weight biopolymeric organic carbon (high-MW OC) which increases the Microbial Growth Potential (MGP) in the feed water and produced drinking water.	Water	47-52	matrix Gla protein	Homo sapiens	318-321
34896810-2	2021	The production of biologically stable drinking water is challenging for conventional surface water treatment plants using reservoirs as feed water due to the presence of slowly biodegradable particulate and high-molecular weight biopolymeric organic carbon (high-MW OC) which increases the Microbial Growth Potential (MGP) in the feed water and produced drinking water.	Water	93-98	matrix Gla protein	Homo sapiens	290-316
34896810-2	2021	The production of biologically stable drinking water is challenging for conventional surface water treatment plants using reservoirs as feed water due to the presence of slowly biodegradable particulate and high-molecular weight biopolymeric organic carbon (high-MW OC) which increases the Microbial Growth Potential (MGP) in the feed water and produced drinking water.	Water	93-98	matrix Gla protein	Homo sapiens	318-321
34896810-2	2021	The production of biologically stable drinking water is challenging for conventional surface water treatment plants using reservoirs as feed water due to the presence of slowly biodegradable particulate and high-molecular weight biopolymeric organic carbon (high-MW OC) which increases the Microbial Growth Potential (MGP) in the feed water and produced drinking water.	Water	141-146	matrix Gla protein	Homo sapiens	290-316
34896810-2	2021	The production of biologically stable drinking water is challenging for conventional surface water treatment plants using reservoirs as feed water due to the presence of slowly biodegradable particulate and high-molecular weight biopolymeric organic carbon (high-MW OC) which increases the Microbial Growth Potential (MGP) in the feed water and produced drinking water.	Water	141-146	matrix Gla protein	Homo sapiens	318-321
34896810-2	2021	The production of biologically stable drinking water is challenging for conventional surface water treatment plants using reservoirs as feed water due to the presence of slowly biodegradable particulate and high-molecular weight biopolymeric organic carbon (high-MW OC) which increases the Microbial Growth Potential (MGP) in the feed water and produced drinking water.	Water	335-340	matrix Gla protein	Homo sapiens	290-316
34896810-2	2021	The production of biologically stable drinking water is challenging for conventional surface water treatment plants using reservoirs as feed water due to the presence of slowly biodegradable particulate and high-molecular weight biopolymeric organic carbon (high-MW OC) which increases the Microbial Growth Potential (MGP) in the feed water and produced drinking water.	Water	335-340	matrix Gla protein	Homo sapiens	318-321
34896810-3	2021	The study presented here provides new insights in the relationship between high-MW OC and MGP for a full-scale surface water treatment plant.	Water	119-124	matrix Gla protein	Homo sapiens	90-93
34896810-6	2021	Intensive field monitoring revealed clear seasonal patterns in the plant"s feed water and treated water levels of high-MW OC, biomass and MGP.	Water	98-103	matrix Gla protein	Homo sapiens	138-141
34945471-4	2021	Pads also contained 20% w/w of glycerol vs. fibroin to induce water insolubility.	Water	62-67	fibroin light chain	Bombyx mori	44-51
34884480-2	2021	Synthetic inhibitors of CDKs are based on 2,6,9-trisubstituted purines and are developed as potential anticancer drugs; however, they have low solubility in water.	Water	157-162	cyclin dependent kinase 2	Homo sapiens	24-28
34836425-0	2021	Association between Water and Energy Requirements with Physical Activity and Fat-Free Mass in Preschool Children in Japan.	Water	20-25	FAT atypical cadherin 1	Homo sapiens	77-80
34747270-10	2022	Then, MANF supplement could suppress the pro-inflammatory factor production, restore BBB integrity and then alleviate infarct volume, neurological scores, brain water content and neutrophil infiltration rate.	Water	161-166	mesencephalic astrocyte-derived neurotrophic factor	Mus musculus	6-10
34606936-3	2021	However, poor water-solubility of VCP inhibitors poses a challenge to their clinical translation as intravitreal injections for retinal treatment.	Water	14-19	valosin-containing protein	Rattus norvegicus	34-37
34699174-1	2021	In this study, the novel application of ATR-FTIR spectroscopy and macro ATR-FTIR spectroscopic imaging overcame an analytical challenge in conservation science: the time-resolved, chemical, and spatial investigation of the reaction of inorganic treatments for stone conservation (ammonium oxalate, AmOx; ammonium phosphate, DAP) occurring in water-based solutions.	Water	342-347	death associated protein	Homo sapiens	324-327
34771400-5	2021	The results indicate that the diffusivity coefficient of the carbon fiber coat is higher than that of internal GFRP in water.	Water	119-124	GTP cyclohydrolase I feedback regulator	Homo sapiens	111-115
34771400-6	2021	Compared to the GFRP bars in water, the HFRP bars have a higher diffusivity coefficient and saturation water absorption.	Water	29-34	GTP cyclohydrolase I feedback regulator	Homo sapiens	16-20
34771400-6	2021	Compared to the GFRP bars in water, the HFRP bars have a higher diffusivity coefficient and saturation water absorption.	Water	103-108	GTP cyclohydrolase I feedback regulator	Homo sapiens	16-20
34828373-2	2021	Forced molting (FM) by fasting in chickens causes aging of their reproductive system and then promotes cell redevelopment by providing water and feed again.	Water	135-140	fibromodulin	Gallus gallus	16-18
34835741-7	2021	In this study, we aimed to formulate curcumin nanoparticles and conjugate with the anti-CD123 to overcome the low water solubility and improve the targeting of LSCs.	Water	114-119	interleukin 3 receptor subunit alpha	Homo sapiens	88-93
34498366-7	2021	At the same time, the adjacent Cu x effectively promotes the protonation of *CO 2 - by accelerating water dissociation and offering *H to the Cu-S 1 N 3 active sites.	Water	100-105	cut like homeobox 1	Homo sapiens	31-35
31106905-0	2019	Skin acidification with a water-in-oil emulsion (pH 4) restores disrupted epidermal barrier and improves structure of lipid lamellae in the elderly.	Water	26-31	prolyl 4-hydroxylase, transmembrane	Homo sapiens	49-53
34529946-6	2021	X-ray reflectivity and vesicle binding studies were used to compare the water-soluble domain of Tim3 with results previously obtained for Tim1 and Tim4.	Water	72-77	hepatitis A virus cellular receptor 2	Mus musculus	96-100
34455300-1	2021	We previously discovered extrahepatic cytochrome P450 1B1 (CYP1B1) degraders able to overcome drug resistance toward docetaxel using a PROTACs technology, however, the underexplored structure activity relationships and poor water solubility posed a major hurdle in the development of CYP1B1 degraders.	Water	224-229	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	59-65
30828737-10	2019	We suggest that PCaP1 contributes to hydrotropism through a MIZ1-independent pathway or as one of the upstream components that transduce water potential signals to MIZ1.	Water	137-142	MIZU-KUSSEI-like protein (Protein of unknown function, DUF617)	Arabidopsis thaliana	164-168
34688179-0	2021	Assessing the differential sensitivities of wave-CAIPI ViSTa myelin water fraction and magnetization transfer saturation for efficiently quantifying tissue damage in MS. BACKGROUND: Wave-CAIPI Visualization of Short Transverse relaxation time component (ViSTa) is a recently developed, short-T1-sensitized MRI method for fast quantification of myelin water fraction (MWF) in the human brain.	Water	68-73	V-set immunoregulatory receptor	Homo sapiens	254-259
30921633-2	2019	The aim of this study was to investigate the influence of different water salinities on the expression of HSP70, PCNA and caspase-3 during spermatogenesis of Nile tilapia.	Water	68-73	caspase 3, apoptosis-related cysteine peptidase a	Oreochromis niloticus	122-131
34688179-0	2021	Assessing the differential sensitivities of wave-CAIPI ViSTa myelin water fraction and magnetization transfer saturation for efficiently quantifying tissue damage in MS. BACKGROUND: Wave-CAIPI Visualization of Short Transverse relaxation time component (ViSTa) is a recently developed, short-T1-sensitized MRI method for fast quantification of myelin water fraction (MWF) in the human brain.	Water	351-356	V-set immunoregulatory receptor	Homo sapiens	254-259
31386675-3	2019	Since aquaporin-2 (AQP2) water channels in the kidney collecting duct (CD) principal cells (PCs) are involved in maintaining water balance, we investigated their role in sex-dependent water homeostasis in wild-type (WT) C57BL/6 mice.	Water	25-30	aquaporin 2	Mus musculus	6-17
34453976-6	2021	Significant cognitive improvement was seen in the reversal trial of 8 arm radial arm water maze in mice treated with exosomes containing MALAT1.	Water	85-90	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	137-143
31386675-3	2019	Since aquaporin-2 (AQP2) water channels in the kidney collecting duct (CD) principal cells (PCs) are involved in maintaining water balance, we investigated their role in sex-dependent water homeostasis in wild-type (WT) C57BL/6 mice.	Water	25-30	aquaporin 2	Mus musculus	19-23
31386675-3	2019	Since aquaporin-2 (AQP2) water channels in the kidney collecting duct (CD) principal cells (PCs) are involved in maintaining water balance, we investigated their role in sex-dependent water homeostasis in wild-type (WT) C57BL/6 mice.	Water	125-130	aquaporin 2	Mus musculus	19-23
31386675-3	2019	Since aquaporin-2 (AQP2) water channels in the kidney collecting duct (CD) principal cells (PCs) are involved in maintaining water balance, we investigated their role in sex-dependent water homeostasis in wild-type (WT) C57BL/6 mice.	Water	125-130	aquaporin 2	Mus musculus	19-23
31382552-2	2019	In this work, a synthesis method for bone morphogenetic protein (BMP-2)-loaded PLGA NPs was developed and optimized, in order to carry out and control the release of BMP-2, based on the double-emulsion (water/oil/water, W/O/W) solvent evaporation technique.	Water	203-208	bone morphogenetic protein 1	Homo sapiens	37-63
31382552-2	2019	In this work, a synthesis method for bone morphogenetic protein (BMP-2)-loaded PLGA NPs was developed and optimized, in order to carry out and control the release of BMP-2, based on the double-emulsion (water/oil/water, W/O/W) solvent evaporation technique.	Water	213-218	bone morphogenetic protein 1	Homo sapiens	37-63
31013057-3	2019	This study examines the evolution of virtual water trade in relation to agricultural products between China and BRI countries during 2000-2016.	Water	45-50	integral membrane protein 2B	Homo sapiens	102-115
31092551-7	2019	After Morris water maze behavioral training, CREB siRNA rats exhibited a memory deficiency, significantly diverging from the control groups.	Water	13-18	cAMP responsive element binding protein 1	Rattus norvegicus	45-49
34850698-14	2021	An unstable pH can alter the chemical and microbiological aspects of water, resulting in a variation of other water quality parameters.	Water	69-74	phenylalanine hydroxylase	Homo sapiens	12-14
31143165-5	2019	Water samples were collected from the Caspian Sea for study in experimental microcosms.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	46-49
34850698-14	2021	An unstable pH can alter the chemical and microbiological aspects of water, resulting in a variation of other water quality parameters.	Water	110-115	phenylalanine hydroxylase	Homo sapiens	12-14
31062106-11	2019	As a consequence, Ag2 (but not Ag1) gels retained more H2O than D2O.	Water	55-58	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	18-21
34718875-4	2021	We employ all-atoms molecular dynamics simulations to study the interaction between the receptor-binding domain of the SARS-CoV-2 spike protein and the phospholipid lecithin (POPC), in water.	Water	185-190	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	130-135
30763638-1	2019	A Mg2+-water bridge between the C-3, C-4 diketo moiety of fluoroquinolones and the conserved amino acid residues in the GyrA/ParC subunit is critical for the binding of a fluoroquinolone to a topoisomerase-DNA covalent complex.	Water	7-12	complement C4A (Rodgers blood group)	Homo sapiens	37-40
31428601-1	2019	A couple of water-soluble chiral 2,6-helic[6]arene derivatives P -H1 and M -H1 were synthesized, and they could form 1:1 stable complexes with 4-[(4"-N, N-diphenylamino)-styryl]-N-methylpyridinium iodide (G) in water.	Water	12-17	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	63-74
31428601-1	2019	A couple of water-soluble chiral 2,6-helic[6]arene derivatives P -H1 and M -H1 were synthesized, and they could form 1:1 stable complexes with 4-[(4"-N, N-diphenylamino)-styryl]-N-methylpyridinium iodide (G) in water.	Water	211-216	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	63-74
34770898-5	2021	As the hinge structure in hDPP III, the conformational changes that took place in the Arg421-Lys423 residue could lead to the changes in the shape and space of the catalytic subsites, which might allow water to function as a nucleophile to attack the substrate.	Water	202-207	dipeptidyl peptidase 3	Homo sapiens	26-34
34916091-0	2022	Duration of cooling with water for thermal burns as a first aid intervention: A systematic review.	Water	25-30	activation induced cytidine deaminase	Homo sapiens	60-63
31943967-1	2019	Biocompatible poly(4-styrenesulfonic acid-co-maleic acid)-stabilized GdF3  : Eu3+ (Tb3+ ) nanoparticles were obtained by a one-step coprecipitation method in ethylene glycol or water.	Water	177-182	growth differentiation factor 3	Homo sapiens	69-73
31080013-4	2019	EAU-challenged IL-22-/- mice, as well as WT mice treated systemically or intraocularly with anti-IL-22 antibodies during the expression phase of disease, developed exacerbated retinal damage.	Water	0-3	interleukin 22	Mus musculus	15-20
30640551-3	2019	METHODS: Indinavir-loaded nanoemulsions (IDV-NEs) were prepared by high-speed homogenization method, and then lactoferrin was coupled to IDV-NEs by water soluble EDC method.	Water	148-153	lactotransferrin	Rattus norvegicus	110-121
30815697-6	2019	Loss of the water channel AQP3, the zinc transporter ZNT1 and its regulator MTF1 also enhanced tolerance to AsIII whereas loss of the multidrug resistance protein ABCC1 increased sensitivity to AsIII.	Water	12-17	aquaporin 3 (Gill blood group)	Homo sapiens	26-30
34916091-1	2022	BACKGROUND: Cooling thermal burns with running water is a recommended first aid intervention.	Water	47-52	activation induced cytidine deaminase	Homo sapiens	76-79
34916091-3	2022	AIM: To perform a systematic review of the evidence for the question; Among adults and children with thermal burn, does active cooling using running water as an immediate first aid intervention for 20 min or more, compared with active cooling using running water for any other duration, change the outcomes of burn size, burn depth, pain, adverse outcome (hypothermia) or complications?	Water	149-154	activation induced cytidine deaminase	Homo sapiens	177-180
34707467-11	2021	Giving Salix extract 50-100 mg/L in drinking water caused an upregulated AQP2 expression; on the other hand, it downregulated HSP-70 expression, in chicken kidney tubules both exposed to heat stress and nonexposed to heat stress.	Water	45-50	aquaporin 2	Gallus gallus	73-77
30860246-0	2019	Acidity and Cd2+ fluorescent sensing and selective CO2 adsorption by a water-stable Eu-MOF.	Water	71-76	CD2 molecule	Homo sapiens	12-15
30860246-2	2019	It is a highly porous, water-stable, and luminescent material, exhibiting pH sensing in the acidic range of pH = 7-3 with selective detection for Cd2+ by an enhanced fluorescence of ~23-fold against a series of metal ions.	Water	23-28	CD2 molecule	Homo sapiens	146-149
30988385-9	2019	By means of the immunoblotting technique, GPR35 was evidenced in the mucosa of the jejunum of 1-day-old rats and distinct morphological changes in the jejunum of 21-day-old rats fed by mothers exposed to water supplemented with KYNA were found.	Water	204-209	G protein-coupled receptor 35	Rattus norvegicus	42-47
30986891-4	2019	We found that the two key tonoplast aquaporins, TIP3;1 and TIP3;2, which have previously been implicated in water or solute transport, respectively, act antagonistically to modulate the response to abscisic acid, with TIP3;1 being a positive and TIP3;2 a negative regulator.	Water	108-113	suppressor of cytokine signaling 1	Homo sapiens	48-52
30986891-4	2019	We found that the two key tonoplast aquaporins, TIP3;1 and TIP3;2, which have previously been implicated in water or solute transport, respectively, act antagonistically to modulate the response to abscisic acid, with TIP3;1 being a positive and TIP3;2 a negative regulator.	Water	108-113	suppressor of cytokine signaling 1	Homo sapiens	59-63
30986891-4	2019	We found that the two key tonoplast aquaporins, TIP3;1 and TIP3;2, which have previously been implicated in water or solute transport, respectively, act antagonistically to modulate the response to abscisic acid, with TIP3;1 being a positive and TIP3;2 a negative regulator.	Water	108-113	suppressor of cytokine signaling 1	Homo sapiens	59-63
30986891-4	2019	We found that the two key tonoplast aquaporins, TIP3;1 and TIP3;2, which have previously been implicated in water or solute transport, respectively, act antagonistically to modulate the response to abscisic acid, with TIP3;1 being a positive and TIP3;2 a negative regulator.	Water	108-113	suppressor of cytokine signaling 1	Homo sapiens	59-63
31264416-5	2019	Coefficients in the model were determined using a data set including the organic carbon-water partition coefficient (KOC) of four polycyclic aromatic hydrocarbons (PAHs) sorption to 10 NOM samples collected from surface waters.	Water	88-93	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	117-120
30961536-6	2019	By data analysis, the response pathway of post-transcriptional regulation concerning salt and water-deprivation stresses was put forward, involving preventing sodium from entering the cell, purifying of water and compensating neutral amino acids by miR-193b, miR-542-5p interaction with SLC6A19 mRNA.	Water	94-99	sodium-dependent neutral amino acid transporter B(0)AT1	Camelus bactrianus	287-294
30961536-6	2019	By data analysis, the response pathway of post-transcriptional regulation concerning salt and water-deprivation stresses was put forward, involving preventing sodium from entering the cell, purifying of water and compensating neutral amino acids by miR-193b, miR-542-5p interaction with SLC6A19 mRNA.	Water	203-208	sodium-dependent neutral amino acid transporter B(0)AT1	Camelus bactrianus	287-294
34723603-0	2021	Hydrogen Bonding Sequence Directed Coil-Globule Transition in Water Soluble Thermoresponsive Polymers.	Water	62-67	coilin	Homo sapiens	35-39
30967532-6	2019	In sea ice covered regions, the sublimation of deposited snow on sea ice is a key process controlling the local water vapour isotopic composition.	Water	112-117	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	3-6
30967532-6	2019	In sea ice covered regions, the sublimation of deposited snow on sea ice is a key process controlling the local water vapour isotopic composition.	Water	112-117	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	65-68
34723603-1	2021	The origin of the coil-globule transition for water-soluble thermoresponsive polymers frequently used in nanomaterials remains elusive.	Water	46-51	coilin	Homo sapiens	18-22
31320940-5	2019	These properties render HNT pivotal in diverse range of applications, such as in environmental sciences, waste-water treatment, dye removal, nanoelectronics and fabrication of nanocomposites, catalytic studies, as glass coatings or anticorrosive coatings, in cosmetics, as flame retardants, stimuli response, and forensic sciences.	Water	111-116	ras responsive element binding protein 1	Homo sapiens	24-27
34723603-2	2021	Using polypropylene oxide as an example we demonstrate by means of atomistic molecular dynamics simulations that temperature-induced increase in the sequence length of monomers that are not hydrogen bonded to water drives the coil-globule transition.	Water	209-214	coilin	Homo sapiens	226-230
31087928-1	2019	In order to improve the adsorption-separation of Cd2+ in water treatment, magnetic Fe3O4 coated Ca(H2PO4)2 nanoparticles (NMCDP) were developed by coprecipitation.	Water	57-62	CD2 molecule	Homo sapiens	49-52
34721962-5	2021	Climate change would increase water supply by 4.85%, 5.18%, 8.16% and water demand by 1.45%, 1.68%, 2.36% under RCP 2.6, 4.5, and 8.5 scenarios by 2050s, respectively.	Water	30-35	CGRP receptor component	Homo sapiens	112-115
31266977-7	2019	Based on CALIPSO satellite observations of cloud properties, this study found that cloud coverage in ice-free regions in the Arctic linearly increased with the area of ice-free water during the melt seasons in the past 10 years, while sea ice coverage varies significantly year-to-year.	Water	177-182	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	199-202
32073578-5	2019	The covalently linked GOx can competitively consume glucose and spontaneously generate ROS H2O2 that can be further converted by the iron oxide NPs into more toxic  OH, inducing apoptosis of cancer cells.	Water	91-95	hydroxyacid oxidase 1, liver	Mus musculus	22-25
34721962-5	2021	Climate change would increase water supply by 4.85%, 5.18%, 8.16% and water demand by 1.45%, 1.68%, 2.36% under RCP 2.6, 4.5, and 8.5 scenarios by 2050s, respectively.	Water	70-75	CGRP receptor component	Homo sapiens	112-115
34581116-8	2021	Focusing on spring and summer, when the risk of water ecological security was high, Chl-a combined with SD and MIB along with their correlation with other water quality indexes, was used to evaluate and optimize the ecological security of Shahe Reservoir.	Water	155-160	chordin like 1	Homo sapiens	84-87
30936009-2	2019	This work aimed to get a novel polysaccharide, termed MRP-1, which was isolated from Moringa oleifera roots with hot water extraction method followed by ethanol precipitation and purified with DEAE-Sepharose Fast Flow column.	Water	117-122	prolactin family 2, subfamily c, member 2	Mus musculus	54-59
34683262-8	2021	Studying the relationship between the ratio of oil-to-water flow rates (Phi) found that increasing Phi resulted in smaller droplets and an enhanced droplet generation rate.	Water	54-59	glucose-6-phosphate isomerase	Homo sapiens	72-75
31189221-6	2019	Specifically, AVP stimulates the intracellular translocation of AQP2-containing vesicles to the apical plasma membrane, increasing the osmotic water permeability of CD cells.	Water	143-148	aquaporin 2	Homo sapiens	64-68
30769280-1	2019	The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water.	Water	219-224	microRNA 126	Homo sapiens	91-98
30769280-1	2019	The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water.	Water	219-224	microRNA 145	Homo sapiens	113-120
30678916-5	2019	When compared with PLC scaffolds the PLC/COL/HA had higher water uptake capacity (103% vs 66%) which may have contributed to the decrease in its Young"s Modulus (from 1.31 to 0.89 MPa).	Water	59-64	heparan sulfate proteoglycan 2	Homo sapiens	37-40
34683262-8	2021	Studying the relationship between the ratio of oil-to-water flow rates (Phi) found that increasing Phi resulted in smaller droplets and an enhanced droplet generation rate.	Water	54-59	glucose-6-phosphate isomerase	Homo sapiens	99-102
34303997-3	2021	Compared with control CS NPs, the as-synthesized CS-PS NPs exhibits excellent hydration and stability because of negatively charged surface zeta potential, along with extraordinary lubrication performance in water for realizing a super-low friction coefficient (COF) as ~0.01 at the sliding interface of PDMS elastomer-Ti6Al4V disk.	Water	208-213	citrate synthase	Homo sapiens	49-51
31070363-3	2019	Our results suggested that drinking water containing ripened Pu-erh tea extract could decrease weight gain, fat accumulation, adipose inflammation, the Firmicutes-to-Bacteroidetes ratio, and metabolic endotoxemia while, in the meantime, improving the intestinal barrier integrity in obese mice.	Water	36-41	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	68-71
31182591-8	2019	PolyPs appear to dehydrate water molecules around beta2m under the unfolded conformation, leading to the preferential stabilization of less water-exposed amyloid fibrils.	Water	27-32	beta-2-microglobulin	Homo sapiens	50-56
31182591-8	2019	PolyPs appear to dehydrate water molecules around beta2m under the unfolded conformation, leading to the preferential stabilization of less water-exposed amyloid fibrils.	Water	140-145	beta-2-microglobulin	Homo sapiens	50-56
31460181-0	2019	Removal of Heavy Metal Water Pollutants (Co2+ and Ni2+) Using Polyacrylamide/Sodium Montmorillonite (PAM/Na-MMT) Nanocomposites.	Water	23-28	complement C2	Homo sapiens	41-44
31460181-1	2019	Nanocomposites composed of polyacrylamide and nanoclay were synthesized via free-radical cross-linking polymerization and used to adsorb Co2+ and Ni2+ ions from water.	Water	161-166	complement C2	Homo sapiens	137-140
31222018-7	2019	The termination of meridional water mass exchange through the Tethyan Seaway resulted in a global reorganization of currents, paved the way to the development of upwelling in the Arabian Sea and possibly led to a strengthening of South Asian Monsoon.	Water	30-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	70-73
31209407-7	2019	Activation of mAChR upregulated the expression of aquaporin 5 (AQP5), the main transporter that mediated water secretion through transcellular pathway, and led to AQP5 trafficking from lipid rafts to non-lipid microdomain.	Water	105-110	aquaporin 5	Homo sapiens	50-61
31209407-7	2019	Activation of mAChR upregulated the expression of aquaporin 5 (AQP5), the main transporter that mediated water secretion through transcellular pathway, and led to AQP5 trafficking from lipid rafts to non-lipid microdomain.	Water	105-110	aquaporin 5	Homo sapiens	63-67
30927593-1	2019	HYPOTHESIS: This study presents the synthesis and characterization of Poly(N-isopropylacrylamide)-co-methacrylic acid (PNIPAM-co-MAA) based multi-responsive soft microgel particles employed as "smart emulsifiers" for controlled stabilization and breakage of the decane-in-water Pickering emulsions.	Water	272-277	MAA	Homo sapiens	129-132
30927596-3	2019	In this work, Rh3+, Ru3+, Pd2+ ions were impregnated on activated carbon derived from pumpkin stalk in distilled water and then reduced with sodium borohydride to form Rh0, Ru0, Pd0 nanoparticles on the surface of carbon.	Water	113-118	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	26-29
31212785-7	2019	When the RAC was no larger than C30 with a water/cement ratio of 0.60 and 0.49, the amount of large particle natural aggregate should be no more than 30%; when the RAC was no less than C40 with a water/cement ratio of 0.41 and 0.36, the amount of large particle natural aggregate should be no less than 50%.	Water	196-201	CCR4-NOT transcription complex subunit 11	Homo sapiens	185-188
31246570-3	2019	Also, the sum of atomic orbital spin populations on the carbon atoms in the skeleton of radicals ( s(C) Sigma AOSPRad), calculated with the semi-empirical parameterisation method 6 (PM6) in water, was used to correlate both Ep1 and AA, yielding R2=0.926 and 0.950, respectively.	Water	190-195	prostaglandin E receptor 1	Homo sapiens	224-227
30903835-5	2019	The column adsorption study revealed that 2-4 times larger water volumes can be treated by GAC-Fe than GAC, reducing the arsenic concentration from 100 mug/L to the WHO guideline of 10 mug/L.	Water	59-64	glutaminase	Homo sapiens	91-97
30903835-5	2019	The column adsorption study revealed that 2-4 times larger water volumes can be treated by GAC-Fe than GAC, reducing the arsenic concentration from 100 mug/L to the WHO guideline of 10 mug/L.	Water	59-64	glutaminase	Homo sapiens	91-94
30919512-8	2019	AQP4 expression is closely relative to the permeability of BSCB and the water content of the spinal cord.	Water	72-77	aquaporin 4	Rattus norvegicus	0-4
30981860-4	2019	For the mice injected with aggregated beta-amyloid (Abeta) fragments to impair learning and memory, activation of M1 receptors could rescue it by reducing the latency to find the platform and spending more time in the target quadrant in the probe test in the Morris water maze.	Water	266-271	amyloid beta (A4) precursor protein	Mus musculus	52-57
31080989-10	2019	We hope that this minireview will encourage researchers to tackle these challenges and innovate NCM-based water disinfection platforms in the near future.	Water	106-111	CWC22 spliceosome associated protein homolog	Homo sapiens	96-99
31088971-4	2019	The impurities are extracted into the aqueous phase in situ, and the localized macroinitiators allow for NCA polymerization at a rate which outpaces water-induced side reactions.	Water	149-154	CEA cell adhesion molecule 6	Homo sapiens	105-108
31392107-1	2019	The sodium-dependent multivitamin transporter that facilitates the uptake of the water-soluble vitamins biotin, pantothenic acid, and the vitamin-like substance lipoate is coded by the SLC5A6 gene.	Water	81-86	solute carrier family 5 member 6	Homo sapiens	4-45
31392107-1	2019	The sodium-dependent multivitamin transporter that facilitates the uptake of the water-soluble vitamins biotin, pantothenic acid, and the vitamin-like substance lipoate is coded by the SLC5A6 gene.	Water	81-86	solute carrier family 5 member 6	Homo sapiens	185-191
31108878-8	2019	3D-RISM calculations on piroxicam-bound DPP-4 were used to understand the stability of water molecules at the active site.	Water	87-92	dipeptidyl peptidase 4	Homo sapiens	40-45
30938512-4	2019	SG-A and SG-B as adsorbents filled in a microcolumn were used to enrich trace Cu ions in foods and water with the detection of flame atomic absorption spectrometry.	Water	99-104	glypican 3	Homo sapiens	9-13
31048895-0	2019	TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice.	Water	36-41	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	0-5
31048895-14	2019	Our data provide evidence that water diffusion is increased in diabetic mouse retinas and that TRPV4 function contributes to retinal hydro-mineral homeostasis and structure under control conditions, and to the development of BRB breakdown and increased water diffusion in the retina under diabetes conditions.	Water	253-258	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	95-100
30990996-11	2019	The limits of detection 0.11-0.22 ng mL-1 were realized in water, human blood plasma, urine, and pharmaceuticals.	Water	59-64	L1 cell adhesion molecule	Mus musculus	37-41
30735848-0	2019	Synthesis of water soluble pentacyclic dihydroxyterpene carboxylic acid derivatives coupled amino acids and their inhibition activities on alpha-glucosidase.	Water	13-18	sucrase-isomaltase	Homo sapiens	139-156
30735848-3	2019	Results reveal that some of the derivatives exhibit a better alpha-glucosidase inhibitory activity than that of acarbose in the test conditions of ethanol-water solution and DMSO.	Water	155-160	sucrase-isomaltase	Homo sapiens	61-78
30735848-5	2019	Unfortunately, all of the derivatives possess lower inhibitory properties of alpha-glucosidase than those of the parent compounds in the measurement system of DMSO solution, even if the derivatives exhibit better water solubility than that of the parent compounds.	Water	213-218	sucrase-isomaltase	Homo sapiens	77-94
30770374-3	2019	We have developed a handheld and biocompatible device coupled to a mass spectrometer, the MasSpec Pen, which uses a discrete water droplet for molecular extraction and rapid tissue diagnosis.	Water	125-130	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	98-101
30825689-7	2019	In contrast, names that invoke desirable characteristics of the water-Pure, Eco-Friendly, and Advanced Purified, were viewed significantly more favorable than the others.	Water	64-69	ciliogenesis associated kinase 1	Homo sapiens	76-79
30988011-1	2019	BACKGROUND: Arginine-vasopressin (AVP) binding to vasopressin V2 receptors promotes redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane of renal collecting duct principal cells.	Water	106-111	aquaporin 2	Mus musculus	133-137
30955786-5	2019	Sensitivity experiments suggested that the horizontal current and vertical stratification associated with air-sea heat flux controlled the seasonal cycle of contaminant concentration in the water column; however, surface wind velocity was the dominant factor affecting the surface contaminant concentration.	Water	190-195	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	110-113
30934973-8	2019	The iodide concentrations in the mineral water samples ranged from 0.58 to 2.88 mg L-1.	Water	41-46	L1 cell adhesion molecule	Mus musculus	83-86
30803233-2	2019	Herein, we perform in situ measurements of water interacting with the ionic liquid (IL) 1-butyl-3-methylimidazolium acetate, [C4mim][Ace], using ambient pressure X-ray photoelectron spectroscopy in order to assess the interfacial uptake of water quantitatively as a function of temperature, pressure, and water mole fraction ( xw).	Water	43-48	interleukin 1 alpha	Homo sapiens	70-89
30803233-2	2019	Herein, we perform in situ measurements of water interacting with the ionic liquid (IL) 1-butyl-3-methylimidazolium acetate, [C4mim][Ace], using ambient pressure X-ray photoelectron spectroscopy in order to assess the interfacial uptake of water quantitatively as a function of temperature, pressure, and water mole fraction ( xw).	Water	240-245	interleukin 1 alpha	Homo sapiens	70-89
30873581-3	2019	Of the 11 described SLC26 isoforms, the SLC26A1,2,3,6,7,9,11 are expressed in the gastrointestinal tract, where they participate in salt and water transport, surface pH-microclimate regulation, affect the microbiome composition, the absorption, and secretion of oxalate and sulfate, and other functions that require further study.	Water	141-146	solute carrier family 26 member 1	Homo sapiens	40-47
30708311-6	2019	This relationship was digitalized in HSC Sim, a mineral processing simulator, turning it into a tool capable of simulating the flotation performance under a variety of process water compositions.	Water	176-181	fucosyltransferase 1 (H blood group)	Homo sapiens	37-40
30634120-0	2019	Encapsulated green magnetic nanoparticles for the removal of toxic Pb2+ and Cd2+ from water: Development, characterization and application.	Water	86-91	CD2 molecule	Homo sapiens	76-79
30604589-0	2019	Quantum Chemical Study of the Mechanism of Water Oxidation Catalyzed by a Heterotrinuclear Ru2 Mn Complex.	Water	43-48	doublecortin domain containing 2	Homo sapiens	91-94
30837562-6	2019	Note that, strain BN-MS2 heterostructures reduce the band edges of MS2 layers and extend their application in photocatalytic water splitting.	Water	125-130	MS2	Homo sapiens	21-24
30837562-6	2019	Note that, strain BN-MS2 heterostructures reduce the band edges of MS2 layers and extend their application in photocatalytic water splitting.	Water	125-130	MS2	Homo sapiens	67-70
30836604-0	2019	One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water.	Water	79-84	nibrin	Homo sapiens	8-11
30637806-0	2019	Solar Energy Triggered Clean Water Harvesting from Humid Air Existing above Sea Surface Enabled by a Hydrogel with Ultrahigh Hygroscopicity.	Water	29-34	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
30637806-4	2019	Alternatively, the air above sea water is moisture rich, with the quantity of vapor increasing at the rate of 0.41 kg m-2 .	Water	33-38	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	29-32
30529856-7	2019	Richard diagram identified four classes of water: (i) C3S1 with 61.5% of samples having moderate or poor quality, (ii) C4S1 (30.2%) having poor or bad quality, (iii) C4S2 (5.2%) having very bad quality, and (iv) C5S3 (3.1%) determined unsuitable for irrigation.	Water	43-48	carbohydrate sulfotransferase 11	Homo sapiens	119-123
30529856-7	2019	Richard diagram identified four classes of water: (i) C3S1 with 61.5% of samples having moderate or poor quality, (ii) C4S1 (30.2%) having poor or bad quality, (iii) C4S2 (5.2%) having very bad quality, and (iv) C5S3 (3.1%) determined unsuitable for irrigation.	Water	43-48	carbohydrate sulfotransferase 12	Homo sapiens	166-170
30544045-3	2019	The biosurfactant obtained with these selected strains showed the capacity of decreasing the surface tension of water from 72.0 to 31.8 mN.m-1 and the interfacial tension of n-hexadecane to 27.2 mN.m-1, with a critical micelle concentration of 12.5 mg.L-1.	Water	112-117	L1 cell adhesion molecule	Mus musculus	252-255
30652231-4	2019	The complexes have eight coordinated structure with the formulae [PrL1-4,6(NO3)2(H2O)3].nH2O where n = 1, 11/2, 3, 4, 4 and [PrL5(NO3)(H2O)5].2H2O.	Water	81-84	protein tyrosine phosphatase 4A1	Homo sapiens	66-70
30652231-4	2019	The complexes have eight coordinated structure with the formulae [PrL1-4,6(NO3)2(H2O)3].nH2O where n = 1, 11/2, 3, 4, 4 and [PrL5(NO3)(H2O)5].2H2O.	Water	89-92	protein tyrosine phosphatase 4A1	Homo sapiens	66-70
30367162-2	2019	Aquaporin-4 mediates cerebral water movement and its absence in models of ischemia improves outcome.	Water	30-35	aquaporin 4	Rattus norvegicus	0-11
30609580-5	2019	With this approach it has been possible to detect E. coli concentration down to 1 CFU mL-1 in potable water and 3.5 CFU mL-1 in apple juice without sample preparation, within only 25 min.	Water	102-107	L1 cell adhesion molecule	Mus musculus	86-90
30609589-7	2019	Good response linearity for the analytes was observed in the range of 0.1-100.0 ng mL-1 for water and 1.0-100.0 ng g-1 for soil samples, with correlation coefficient &gt;= 0.9989 and &gt;= 0.9924, respectively.	Water	92-97	L1 cell adhesion molecule	Mus musculus	83-87
30609589-8	2019	The limits of detection calculated at a signal-to-noise ratio of 3 (S/N = 3) were in the range from 0.01 to 0.03 ng mL-1 for the water and 0.1-0.2 ng g-1 for the soil sample, respectively.	Water	129-134	L1 cell adhesion molecule	Mus musculus	116-120
30609598-7	2019	The utilization of VIM-EDMA column for potential environmental application was also demonstrated by determining the occurrence of inorganic anions in various environmental water samples without sample preparation process.	Water	172-177	vimentin	Homo sapiens	19-22
30529825-2	2019	The water extracts had the highest antioxidant activity, especially those from roots and flowers, and were further appraised for in vitro inhibition of enzymes implicated on the onset of human ailments, namely acetyl- (AChE) and butyrylcholinesterase (BuChE) for Alzheimer"s disease, alpha-glucosidase and alpha-amylase for diabetes, and tyrosinase for skin hyperpigmentation disorders.	Water	4-9	butyrylcholinesterase	Homo sapiens	229-250
30529825-2	2019	The water extracts had the highest antioxidant activity, especially those from roots and flowers, and were further appraised for in vitro inhibition of enzymes implicated on the onset of human ailments, namely acetyl- (AChE) and butyrylcholinesterase (BuChE) for Alzheimer"s disease, alpha-glucosidase and alpha-amylase for diabetes, and tyrosinase for skin hyperpigmentation disorders.	Water	4-9	butyrylcholinesterase	Homo sapiens	252-257
30781533-6	2019	The absorption capacities of PAA-AM/FA for pure water and 0.9% NaCl solution were found to be 976 g g-1 and 81 g g-1, respectively.	Water	48-53	goliath	Drosophila melanogaster	100-116
30463143-9	2019	There is also insufficient evidence to conclude that people at water institutions in San Antonio would have a higher frequency of communication with other water, energy, and food stakeholder in correlation with a higher level of concern about future water availability in the Region.	Water	63-68	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	85-88
31459547-5	2019	The thermoresponsive study indicated that the fluorescence intensity of NR decreased with the increase of temperature of the micellar solution because of the release of NR into water arising from the contraction of the amphiphilic BCP.	Water	177-182	opsin 1, short wave sensitive	Homo sapiens	231-234
30584808-1	2019	Several aquaporin (AQP) water channels are short-term regulated by the messenger cyclic adenosine monophosphate (cAMP), including AQP3.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	130-134
30584808-7	2019	This regulation of AQP3 organization at the nanoscale may be important for understanding the mechanisms of water AQP3-mediated water transport across plasma membranes.	Water	107-112	aquaporin 3 (Gill blood group)	Homo sapiens	19-23
30584808-7	2019	This regulation of AQP3 organization at the nanoscale may be important for understanding the mechanisms of water AQP3-mediated water transport across plasma membranes.	Water	107-112	aquaporin 3 (Gill blood group)	Homo sapiens	113-117
30584808-7	2019	This regulation of AQP3 organization at the nanoscale may be important for understanding the mechanisms of water AQP3-mediated water transport across plasma membranes.	Water	127-132	aquaporin 3 (Gill blood group)	Homo sapiens	19-23
30584808-7	2019	This regulation of AQP3 organization at the nanoscale may be important for understanding the mechanisms of water AQP3-mediated water transport across plasma membranes.	Water	127-132	aquaporin 3 (Gill blood group)	Homo sapiens	113-117
30556289-3	2019	Reported here is that the syn isomer [FeIV (Osyn )(TMC)(NCMe)]2+ (2) converts into its anti form [FeIV (Oanti )(TMC)(NCMe)]2+ (1) in MeCN, an isomerization facilitated by water and monitored most readily by 1 H NMR and Raman spectroscopy.	Water	171-176	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	51-54
30556289-3	2019	Reported here is that the syn isomer [FeIV (Osyn )(TMC)(NCMe)]2+ (2) converts into its anti form [FeIV (Oanti )(TMC)(NCMe)]2+ (1) in MeCN, an isomerization facilitated by water and monitored most readily by 1 H NMR and Raman spectroscopy.	Water	171-176	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	112-115
30290353-4	2019	The highest concentrations were found in the dissolved fraction of Ross Sea water, with vanillin, vanillic acid, acetovanillone and p-coumaric acid being the most abundant PC.	Water	76-81	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	72-75
30290353-6	2019	This facilitated the sea water-air exchange by bubble busting processes.	Water	25-30	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	21-24
30625272-3	2019	Here, we demonstrate that nonresonant angle-resolved second-harmonic scattering detects alpha-synuclein binding to liposomes through changes in water orientational correlations and can thus be used as a high-accuracy and high-throughput label-free probe of protein-liposome interactions.	Water	144-149	synuclein alpha	Homo sapiens	88-103
30616342-2	2019	In this MOF, the two lanthanides and ligand (H4L) form three luminescence centers, and they have different sensitivity toward water and temperature.	Water	126-131	H4 clustered histone 7	Homo sapiens	45-48
30629415-0	2019	Prospective Water Supply Mix for Life Cycle Assessment and Resource Policy Support-Assessment of Forecasting Scenarios Accounting for Future Changes in Water Demand and Availability.	Water	12-17	Mix paired-like homeobox	Homo sapiens	25-28
30629415-6	2019	Projections of the three main components of the P-WSmix (i.e., water sources mix (P-WOmix), technology evolutions, and associated electricity mix) are proposed for two water users (public water and irrigation), under three scenarios and time horizons until mid-21st century.	Water	168-173	Mix paired-like homeobox	Homo sapiens	52-55
30340173-9	2019	Additionally, the MOx/CePO4 catalyst exhibits an excellent water tolerance and N2 selectivity.	Water	59-64	monooxygenase DBH like 1	Homo sapiens	18-21
30800291-1	2019	The alteration of water balance and related disorders has emerged as being strictly linked to the state of activation of the vasopressin-aquaporin-2 (vasopressin-AQP2) pathway.	Water	18-23	aquaporin 2	Homo sapiens	162-166
30427219-1	2019	Hypertonicity increases water permeability, independently of vasopressin, in the inner medullary collecting duct (IMCD) by increasing aquaporin-2 (AQP2) membrane accumulation.	Water	24-29	aquaporin 2	Rattus norvegicus	147-151
30427219-13	2019	Hypertonicity-stimulated water reabsorption by PKC may be related to the decrease in endocytosis of AQP2.	Water	25-30	aquaporin 2	Rattus norvegicus	100-104
30367970-5	2019	Furthermore, using a radial arm water maze, the main effect was observed on working memory which was significantly impaired in Abeta-Tau group only 3 months post injections.	Water	32-37	microtubule associated protein tau	Homo sapiens	133-136
30604254-4	2019	First, immunohistochemistry, immunofluorescence and electron microscopy showed that Atg5 and beta-catenin were highly expressed in human fibrotic liver and mouse liver injury induced by feeding a 50% choline-deficient diet plus 0.15% ethionine solution in drinking water (CDE diet) for 21 days; in addition, these factors were expressed in CK19-positive HPCs.	Water	265-270	catenin beta 1	Homo sapiens	93-105
30604973-5	2019	The water-assisted proton transfer process in inosine was investigated using ab initio MP2 and SCS-MP2 quantum chemical approaches.	Water	4-9	tryptase pseudogene 1	Homo sapiens	87-90
30604973-5	2019	The water-assisted proton transfer process in inosine was investigated using ab initio MP2 and SCS-MP2 quantum chemical approaches.	Water	4-9	tryptase pseudogene 1	Homo sapiens	99-102
30678081-6	2019	Focusing on the water-specific aquaporins (AQP0-AQP5), we discuss how gating and trafficking are controlled by phosphorylation and how phosphorylation affects the binding of aquaporins to regulatory proteins, thereby highlighting structural details and dissecting the contribution of individual phosphorylated residues when possible.	Water	16-21	aquaporin 5	Homo sapiens	48-52
30406798-3	2019	In this project, we report a water-soluble near-infrared (NIR) fluorescent probe (CHMC-M-Leu) for specific monitoring of LAP in vitro and in vivo.	Water	29-34	LAP	Homo sapiens	121-124
30669614-1	2019	The fruit and hulls of the water caltrop (Trapa taiwanensis Nakai) are used as hepatoprotective herbal tea ingredients in Taiwan.	Water	27-32	signal sequence receptor subunit 1	Homo sapiens	42-47
30733814-9	2019	PGE2 decreased AQP3 expression which inhibits water absorbed from the intestine to the blood vessel side, resulting in the laxative effect of RFP.	Water	46-51	aquaporin 3 (Gill blood group)	Rattus norvegicus	15-19
34157270-9	2021	The proposed IWRM-DMS has been proposed to analyse the water quality to ensure water distribution in a rural area to achieve less MAPE (21.41%) and RMSE(15.12%), improve efficiency (96.93%), Reliability (98.24%), enhance prediction (95.29%)), the overall performance (97.34%), moisture content ratio (7.4%), cost-effectiveness ratio (95.7%) when compared to other popular methods.	Water	55-60	PRAME nuclear receptor transcriptional regulator	Homo sapiens	130-134
29455526-4	2019	The need for multiple ligand structures for accurate GPCR structure-based drug design is demonstrated by the different growing vectors identified for the head groups of M-MPEP and mavoglurant and by the unexpected water-mediated receptor interactions of a new chemotype represented by fenobam.	Water	214-219	C-X-C motif chemokine receptor 6	Homo sapiens	53-57
34157270-9	2021	The proposed IWRM-DMS has been proposed to analyse the water quality to ensure water distribution in a rural area to achieve less MAPE (21.41%) and RMSE(15.12%), improve efficiency (96.93%), Reliability (98.24%), enhance prediction (95.29%)), the overall performance (97.34%), moisture content ratio (7.4%), cost-effectiveness ratio (95.7%) when compared to other popular methods.	Water	79-84	PRAME nuclear receptor transcriptional regulator	Homo sapiens	130-134
31474731-4	2019	KF and NIRS were applicable as measurement methods of the water content in semi-solid formulations.	Water	58-63	arylformamidase	Homo sapiens	0-2
31474731-7	2019	KF and NIR measurements can be used to choose external skin preparations to control the amount of water in PU treatment.	Water	98-103	arylformamidase	Homo sapiens	0-2
34228999-5	2021	Our results showed that overexpression and interference of NRXN1 in vivo, respectively, affected learning and memory, as was assessed by Morris water maze tests, in spontaneously hypertensive rats (SHRs) and Sprague Dawley (SD) rats.	Water	144-149	neurexin 1	Rattus norvegicus	59-64
30907314-9	2019	The expression levels of p- JAK2/JAK2, p-STAT3/STAT3 were upregulated in the hydrogen-rich water group compared with the control group, and p-STAT1/STAT1 was downregulated in the hydrogen-rich water group compared with the control group.	Water	91-96	signal transducer and activator of transcription 3	Rattus norvegicus	41-46
30907314-9	2019	The expression levels of p- JAK2/JAK2, p-STAT3/STAT3 were upregulated in the hydrogen-rich water group compared with the control group, and p-STAT1/STAT1 was downregulated in the hydrogen-rich water group compared with the control group.	Water	91-96	signal transducer and activator of transcription 3	Rattus norvegicus	47-52
30907314-11	2019	CONCLUSION: Hydrogen-rich water may inhibit the apoptosis of cardiomyocytes after ischaemia-reperfusion by upregulating the expression of the JAK2-STAT3 signalling pathway, which reduces ischaemia-reperfusion injury.	Water	26-31	signal transducer and activator of transcription 3	Rattus norvegicus	147-152
34659162-1	2021	The increasing occurrence of multidrug-resistant (MDR) extended-spectrum beta-lactamase- (ESBL) and/or AmpC beta-lactamase- (AmpC) producing Enterobacterales in irrigation water and associated irrigated fresh produce represents risks related to the environment, food safety, and public health.	Water	172-177	CTX-M-15	Klebsiella pneumoniae	55-88
34659162-1	2021	The increasing occurrence of multidrug-resistant (MDR) extended-spectrum beta-lactamase- (ESBL) and/or AmpC beta-lactamase- (AmpC) producing Enterobacterales in irrigation water and associated irrigated fresh produce represents risks related to the environment, food safety, and public health.	Water	172-177	beta-lactamase	Klebsiella pneumoniae	103-107
34659162-1	2021	The increasing occurrence of multidrug-resistant (MDR) extended-spectrum beta-lactamase- (ESBL) and/or AmpC beta-lactamase- (AmpC) producing Enterobacterales in irrigation water and associated irrigated fresh produce represents risks related to the environment, food safety, and public health.	Water	172-177	beta-lactamase	Klebsiella pneumoniae	125-129
34223950-11	2021	RESULTS: Across experiments, CS+, but not CS-, presentations increased water-associated lever pressing during testing, even though responding was reinforced neither by water nor the CS+.	Water	71-76	citrate synthase	Rattus norvegicus	29-31
31588538-6	2019	The aquaporin-2 water channel (AQP2) is expressed in the principal cells, and it plays an essential role in the reabsorption of water in the collecting ducts via type 2 vasopressin receptor (V2R)-mediated mechanism.	Water	16-21	aquaporin 2	Homo sapiens	31-35
31588538-6	2019	The aquaporin-2 water channel (AQP2) is expressed in the principal cells, and it plays an essential role in the reabsorption of water in the collecting ducts via type 2 vasopressin receptor (V2R)-mediated mechanism.	Water	128-133	aquaporin 2	Homo sapiens	31-35
31556577-2	2019	As transmembrane water channels, aquaporins 1 and 4 (AQP1 and AQP4) are involved in the pathogenesis of hydrocephalus.	Water	17-22	aquaporin 4	Rattus norvegicus	62-66
34223950-12	2021	Intra-BLA LY379268 abolished both CS+ potentiated pressing on the water-associated lever and CS+ evoked conditioned approach to the site of water delivery.	Water	140-145	citrate synthase	Rattus norvegicus	93-95
34591181-2	2022	MATERIALS AND METHODS: To prepare the hCS particles, white Portland cement was mixed with distilled water and ground into a fine powder.	Water	100-105	citrate synthase	Homo sapiens	38-41
30909245-6	2019	We found that STZ-treated APP-PS1 mice exhibited poorer performance in the social recognition test, Morris water maze, and plus-maze discriminative avoidance task, compared to saline-treated normoglycemic APP-PS1 mice, likely resulting from increases in brain deposition of amyloid-beta peptide aggregates (Abeta).	Water	107-112	presenilin 1	Mus musculus	30-33
31074077-2	2019	Renal expression of aquaporin-2 (AQP2), a water channel protein, has been shown to be altered in pcy mice.	Water	42-47	aquaporin 2	Mus musculus	20-31
31074077-2	2019	Renal expression of aquaporin-2 (AQP2), a water channel protein, has been shown to be altered in pcy mice.	Water	42-47	aquaporin 2	Mus musculus	33-37
34363824-1	2021	The in vitro and in vivo immunoregulatory activity of a water-soluble sulfated fucan AL1-1 from the sea cucumber A. leucoprocta was elucidated.	Water	56-61	ephrin A5	Mus musculus	85-88
30966745-1	2019	We report the in situ self-assembly of TTF, TTF +, and BF4- or PF6- into p-type semiconductors on the surface of Pt microparticles dispersed in water/acetonitrile mixtures.	Water	144-149	ras homolog family member H	Homo sapiens	39-42
30966745-2	2019	The visible light photoactivation of these self-assemblies leads to water oxidation forming O2 and H+, with an efficiency of 100% with respect to the initial concentration of TTF +.	Water	68-73	ras homolog family member H	Homo sapiens	175-178
30966745-3	2019	TTF + is then completely reduced to TTF upon photoreduction with water.	Water	65-70	ras homolog family member H	Homo sapiens	0-3
30966745-3	2019	TTF + is then completely reduced to TTF upon photoreduction with water.	Water	65-70	ras homolog family member H	Homo sapiens	36-39
30395835-0	2019	Steric Repulsion Forces Contributed by PEGylation of Interleukin-1 Receptor Antagonist Reduce Gelation and Aggregation at the Silicone Oil-Water Interface.	Water	139-144	interleukin 1 receptor antagonist	Homo sapiens	53-86
31105987-2	2018	Most oxidations of chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize mixed-function oxidase stoichiometry, utilizing pyridine nucleotides as electron donors: NAD(P)H + O2 + R   NAD(P)+ + RO + H2O (where R is a carbon substrate and RO is an oxidized product).	Water	230-233	peptidylprolyl isomerase G	Homo sapiens	69-72
34547049-4	2021	In surface water sources, higher values of chloride (OR = 0.891, p<005), phosphates (OR = 0.452, p<0.05), pH (OR = 0.174, p<0.05) and zinc (OR = 0.001, p<0.05) were associated with lower odds of faecal coliform contamination.	Water	11-16	phenylalanine hydroxylase	Homo sapiens	106-108
29730794-12	2018	in the Baltic Sea enhance the phosphorus fluxes from sediment to water on a sea basin scale.	Water	65-70	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	14-17
29730794-12	2018	in the Baltic Sea enhance the phosphorus fluxes from sediment to water on a sea basin scale.	Water	65-70	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
31001697-0	2019	Simultaneous extraction of Cu2+ and Cd2+ ions in water, wastewater, and food samples using solvent-terminated dispersive liquid-liquid microextraction: optimization by multiobjective evolutionary algorithm based on decomposition.	Water	49-54	CD2 molecule	Homo sapiens	36-39
34547049-9	2021	For ground water systems, higher values of pH (OR = 0.083, p<0.05), phosphates (OR = 0.092, p<0.05), turbidity (OR = 0.950, p<0.05) and chloride (OR = 0.860, p<0.05) were associated with lower odds of total coliform contamination.	Water	11-16	phenylalanine hydroxylase	Homo sapiens	43-45
34577184-4	2021	This work overviews the main electrode materials used for the different environmental remediation processes, discusses the main performance enhancements achieved via the utilization of MOFs compared to traditional materials, and provides perspective and insights for the further development of the utilization of MOF-derived materials in electrified water treatment.	Water	350-355	lysine acetyltransferase 8	Homo sapiens	313-316
29683360-0	2018	Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Abeta clearance.	Water	14-19	presenilin 1	Mus musculus	76-79
29683360-5	2018	We found that hydrogen-rich water significantly improved cognitive behaviour in female transgenic AD mice without affecting Abeta clearance, and reversed the brain oestrogen level, ERbeta, and brain-derived neurotrophic factor (BDNF) expressions that were damaged in female transgenic AD mice, but not in males.	Water	28-33	amyloid beta (A4) precursor protein	Mus musculus	124-129
29683360-5	2018	We found that hydrogen-rich water significantly improved cognitive behaviour in female transgenic AD mice without affecting Abeta clearance, and reversed the brain oestrogen level, ERbeta, and brain-derived neurotrophic factor (BDNF) expressions that were damaged in female transgenic AD mice, but not in males.	Water	28-33	Era (G-protein)-like 1 (E. coli)	Mus musculus	181-187
29683360-5	2018	We found that hydrogen-rich water significantly improved cognitive behaviour in female transgenic AD mice without affecting Abeta clearance, and reversed the brain oestrogen level, ERbeta, and brain-derived neurotrophic factor (BDNF) expressions that were damaged in female transgenic AD mice, but not in males.	Water	28-33	brain derived neurotrophic factor	Mus musculus	193-226
29683360-5	2018	We found that hydrogen-rich water significantly improved cognitive behaviour in female transgenic AD mice without affecting Abeta clearance, and reversed the brain oestrogen level, ERbeta, and brain-derived neurotrophic factor (BDNF) expressions that were damaged in female transgenic AD mice, but not in males.	Water	28-33	brain derived neurotrophic factor	Mus musculus	228-232
34584907-3	2021	Our results showed that 1 h exposure to water avoidance stress (WAS) for 7 consecutive days decreased histone acetylation at the GR promoter and increased histone acetylation at the CRH promoter in the CeA.	Water	40-45	carcinoembryonic antigen gene family 4	Rattus norvegicus	202-205
30064749-6	2018	Among the examined lipases, immobilized Candida antarctica lipase B (Novozyme 435) provided the highest reaction yield at a water activity close to zero.	Water	124-129	PAN0_003d1715	Moesziomyces antarcticus	19-25
30550968-8	2019	Moreover, the CDs/C11-Fe3O4 were also applied for the detection of BaP in large-volume water samples, which satisfies the China environmental protection standard, are promising candidates for water remediation.	Water	87-92	prohibitin 2	Homo sapiens	67-70
30550968-8	2019	Moreover, the CDs/C11-Fe3O4 were also applied for the detection of BaP in large-volume water samples, which satisfies the China environmental protection standard, are promising candidates for water remediation.	Water	192-197	prohibitin 2	Homo sapiens	67-70
30738350-3	2019	The water soluble fluorescent probe 2 displayed ultrafast and specific response to H2S displaying NIR fluorescence of 115-fold turn-on with the detection limit of 11 nM without assistance of organic solvent or surfactant.	Water	4-9	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	83-86
34564516-5	2021	The optimized PES/Fe-TA-PEI membrane possesses high pure water flux (124.6 L m-2 h-1) and excellent dye rejections (98.5%, 99.8%, 98.4%, and 86.4% for Congo red, Eriochrome black T, Alcian blue 8GX, and Bromophenol blue, respectively) under 2 bar operation pressure.	Water	57-62	pescadillo ribosomal biogenesis factor 1	Homo sapiens	14-17
31312674-8	2019	Core body temperature rate of change increased significantly with warmer water temperature (Tw34.4, 0.39 +- 0.28 C h-1; Tw35.8, 0.80 +- 0.19 C h-1; Tw37.2, 2.02 +- 0.31 C h-1; Tw38.6, 3.54 +- 0.41 C h-1).	Water	73-78	H1.5 linker histone, cluster member	Homo sapiens	115-118
29676801-12	2018	At 12 months of age, hypoxia-exposed male mice displayed a compromised response to a water deprivation challenge, which was was correlated with an altered cellular composition of the collecting duct and diminished expression of aquaporin 2.	Water	85-90	aquaporin 2	Mus musculus	228-239
34563021-4	2021	HUS pretreatment and TGase-mediated cross-linking significantly increased the water-holding capacity but decreased the swelling ratios of the gels (p < 0.05).	Water	78-83	transglutaminase 1	Homo sapiens	21-26
30245242-5	2018	In vivo, treatment of APP/PS1 mice with HU (45 mg/kg/d) improved spatial memory performance in the hippocampus-dependent Morris water maze task without reducing Abeta levels.	Water	128-133	presenilin 1	Mus musculus	26-29
30624392-7	2019	The 6-month mean change in neural canal deformation was 0.96 and -0.04 (P=0.001) and in CSFp was -128 and -38 mm H2O (P=0.001), but CSFp-IOP difference change was not significant, in the ACZ and placebo groups, respectively.	Water	113-116	colony stimulating factor 2	Homo sapiens	88-92
34503049-5	2021	This paper reviews the effects of several factors such as pH, biosorbent dosage, initial dye concentration, contact time and temperature when utilizing chitosan-based materials as biosorbent for removing of organic dyes from contaminated water.	Water	238-243	phenylalanine hydroxylase	Homo sapiens	58-60
30976294-7	2019	The paper microarray with alpha-glucosidase immobilized was used to screen active compounds in the water extracts of mulberry leaves and lotus leaves.	Water	99-104	sucrase-isomaltase	Homo sapiens	26-43
30257138-5	2018	However, sEMG from the rectus femoris presented a significant difference between pretest and posttest measurements in both water-based protocols with greater values in the measurement after the end of the protocol (p = .046).	Water	123-128	semenogelin 1	Homo sapiens	9-13
34562901-0	2021	MoS2/PPy Nanocomposite as a Transducer for Electrochemical Aptasensor of Ampicillin in River Water.	Water	93-98	pancreatic polypeptide	Homo sapiens	5-8
30454615-13	2018	By combining target prediction and examination, we identified AQP2 as the direct mechanistic target of miR-137 that affected the water permeability of vaginal epithelial cells.	Water	129-134	aquaporin 2	Homo sapiens	62-66
30776430-4	2019	Here we apply the co-alchemical water approach to study the efficacy of FEP calculations of charge changing mutations at the protein-protein interface for the antibody-gp120 system investigated previously and three additional complexes.	Water	32-37	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	168-173
34358905-2	2021	Conventional analytical techniques for determining TN in water usually involve long and tedious procedures with extensive sample preparation for digestion and titration.	Water	57-62	C-type lectin domain family 3 member B	Homo sapiens	51-53
30925715-1	2019	Aquaporin-3 (AQP3) plays an important role in water transport in the gastrointestinal (GI) tract.	Water	46-51	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
30366672-1	2018	OBJECTIVES: Aquaporin-2 (AQP2) is an important water channel protein that is expressed in the renal collecting duct and plays a key role in urine concentration and body water homeostasis.	Water	47-52	aquaporin 2	Homo sapiens	12-23
30925715-1	2019	Aquaporin-3 (AQP3) plays an important role in water transport in the gastrointestinal (GI) tract.	Water	46-51	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
34483144-7	2021	The anti-inflammatory effect of betaine was confirmed by the downregulation of pro-inflammation-related molecules, including vascular cell adhesion molecule 1 and interleukin-1beta in the retinas of rats with EAU.	Water	209-212	vascular cell adhesion molecule 1	Rattus norvegicus	125-158
30843903-1	2019	We have theoretically investigated the hydrogen abstraction reactions of H2O, H2S, CH3OH, and CH3SH by the CCl3 radical, which is of interest in atmospheric chemistry research.	Water	73-76	C-C motif chemokine ligand 3	Homo sapiens	107-111
30366672-1	2018	OBJECTIVES: Aquaporin-2 (AQP2) is an important water channel protein that is expressed in the renal collecting duct and plays a key role in urine concentration and body water homeostasis.	Water	47-52	aquaporin 2	Homo sapiens	25-29
30533410-3	2018	The results showed that ZSR-P had a good effect on the adsorption and removal of Cd2+ in water.	Water	89-94	CD2 molecule	Homo sapiens	81-84
34455501-7	2021	The peptide-loaded CS/SF nanofiber displayed appropriate mechanical properties, high water uptake, suitable biodegradation rate, a controlled release without cytotoxicity on Hu02 human foreskin fibroblast cells at the 16 and 32 microg/ml concentrations of peptide.	Water	85-90	citrate synthase	Homo sapiens	19-24
30295801-6	2018	Ets-1 residues could therefore offset the loss of favorable hydration contributions in PU.1 via low-water interactions, but at the cost of decreased selectivity at base positions flanking the 5"-GGA-3" core consensus.	Water	100-105	ETS proto-oncogene 1, transcription factor	Homo sapiens	0-5
30843903-7	2019	This study provides the first theoretical and kinetic determination of the CCl3 rate coefficient for reactions with H2O, H2S, CH3OH, and CH3SH over a large temperature range.	Water	116-119	C-C motif chemokine ligand 3	Homo sapiens	75-79
34512271-6	2021	Our results indicated that alcohol exposure (either 5% or 10% in drinking water) for 3 weeks remarkably reduced mGFP + /NG2- new myelin and mGFP + /CC1 + new oligodendrocytes in the prefrontal cortex and corpus callosum of 6-month-old NG2-CreERt; mT/mG mice as compared to controls without changing the mGFP + /NG2 + oligodendrocyte precursor cells (OPCs) density, suggesting that alcohol exposure may inhibit oligodendrocyte differentiation.	Water	74-79	RB1-inducible coiled-coil 1	Mus musculus	148-151
30971898-8	2019	Finally, the neuroprotective function of miR-30b-5p is measured by brain water content, mNSSs and beam-walking test.	Water	73-78	microRNA 30b	Mus musculus	41-48
30747516-6	2019	In more detail, this agent interrupts the network between water molecules and weakens the hydrophobic interactions between proteins, remarkably improving detection capabilities to target tau protein.	Water	58-63	microtubule associated protein tau	Homo sapiens	187-190
30639663-4	2019	Contact angle measurements gave an estimate of MS2 hydrophilicity in terms of free energy of interfacial interaction in water.	Water	120-125	MS2	Homo sapiens	47-50
30901874-1	2019	Aquaporin 2 (AQP2) mediates the osmotic water permeability of the kidney collecting duct in response to arginine vasopressin (VP) and is essential for body water homeostasis.	Water	40-45	aquaporin 2	Mus musculus	0-11
30901874-1	2019	Aquaporin 2 (AQP2) mediates the osmotic water permeability of the kidney collecting duct in response to arginine vasopressin (VP) and is essential for body water homeostasis.	Water	40-45	aquaporin 2	Mus musculus	13-17
30901874-1	2019	Aquaporin 2 (AQP2) mediates the osmotic water permeability of the kidney collecting duct in response to arginine vasopressin (VP) and is essential for body water homeostasis.	Water	156-161	aquaporin 2	Mus musculus	0-11
30901874-1	2019	Aquaporin 2 (AQP2) mediates the osmotic water permeability of the kidney collecting duct in response to arginine vasopressin (VP) and is essential for body water homeostasis.	Water	156-161	aquaporin 2	Mus musculus	13-17
30729964-10	2019	It was demonstrated that DPPG is an active component that prevents the BaP molecule from entering the water subphase; as a minor component of LS it can effectively reduce this process.	Water	102-107	prohibitin 2	Homo sapiens	71-74
30960508-5	2019	Moreover, the CA membrane coupled with MgAl-LDH/Sep exhibits a multifunctional characteristic for the efficient removal of mesitylene (99.2%), petroleum ether (99.03%), decane (99.07%), kerosene (99.4%) and heavy metal ion in water due to the layer-by-layer sieving.	Water	226-231	plexin B1	Homo sapiens	48-51
31057736-2	2019	FA-Pep-1 and FA-Pep-2 were synthesized and radiolabeled with 99mTc(CO)3(H2O)3.	Water	72-75	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	3-8
30728110-0	2019	Synthesis and anti-tumor activity study of water-soluble PEG-celastrol coupling derivatives as self-assembled nanoparticles.	Water	43-48	progestagen associated endometrial protein	Homo sapiens	57-60
30989000-1	2019	Objective: The aim of the study was to evaluate the hepatoprotective activity of the bark extract (Ethanol: Water) in the ratio of (3:1) of Rhizophora mucronata (BERM) by intoxicating the HepG2 cell lines with different toxicants viz, CCL4, Ethanol and Paracetamol with different concentrations of the extract were used.	Water	108-113	C-C motif chemokine ligand 4	Homo sapiens	235-239
30804465-6	2019	The shift to the present-day fresher water distribution in the Murray estuary requires a fall in sea level to present-day conditions.	Water	37-42	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	97-100
30223221-10	2019	The results demonstrate that restoring the level of the Sea of Galilee will require reductions in groundwater pumping, surface water diversions, and water consumption by irrigated agriculture.	Water	104-109	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	56-59
32255103-1	2019	An iron-responsive optical probe has been developed for simultaneous sensing of both ferritin and apoferritin proteins at pH 7.4 in water.	Water	132-137	ferritin heavy chain 1	Homo sapiens	98-109
30681870-3	2019	Taking CdS/reduced graphene oxide (CdS/RGO) nanoheterojunctions as a model solar water splitting system, we attempt here to highlight the interaction-dependent interfacial charge-transfer behavior based on both experimental observations and theoretical calculations.	Water	81-86	CDP-diacylglycerol synthase 1	Homo sapiens	7-10
30681870-3	2019	Taking CdS/reduced graphene oxide (CdS/RGO) nanoheterojunctions as a model solar water splitting system, we attempt here to highlight the interaction-dependent interfacial charge-transfer behavior based on both experimental observations and theoretical calculations.	Water	81-86	CDP-diacylglycerol synthase 1	Homo sapiens	35-38
30290355-8	2019	Similarly, enterococci ranged 59-4 cfu mL-1 and 1450-240 cfu g-1 in water and mussels, respectively.	Water	68-73	L1 cell adhesion molecule	Mus musculus	39-64
30592336-2	2019	Herein, with the designed artificial interfaces due to the introduction of water-miscible isopropanol, the gelation of GO is achieved in water at an ultralow concentration (0.1 mg mL-1 , the lowest ever-reported) with a solvothermal treatment.	Water	75-80	L1 cell adhesion molecule	Mus musculus	180-184
30592336-2	2019	Herein, with the designed artificial interfaces due to the introduction of water-miscible isopropanol, the gelation of GO is achieved in water at an ultralow concentration (0.1 mg mL-1 , the lowest ever-reported) with a solvothermal treatment.	Water	137-142	L1 cell adhesion molecule	Mus musculus	180-184
29869756-2	2019	beta2-Microglobulin (beta2-m), a water-soluble, middle-sized molecule, is associated with mortality and dialysis-related amyloidosis (DRA).	Water	33-38	beta-2-microglobulin	Homo sapiens	0-19
30596495-0	2019	Kinetics of the Hydrogen Abstraction PAH +  OH   PAH Radical + H2O Reaction Class: An Application of the Reaction Class Transition State Theory (RC-TST) and Structure-Activity Relationship (SAR).	Water	63-66	thiosulfate sulfurtransferase	Homo sapiens	148-151
30596495-1	2019	A reaction class transition state theory (RC-TST) augmented with structure-activity relationship (SAR) methodology is applied to predict high-pressure limit thermal rate constants for hydrogen abstraction by  OH radical from polycyclic aromatic hydrocarbons (PAHs) reaction class in the temperature range of 300-3000 K. The rate constants for the reference reaction of C6H6 +  OH   C6H5 + H2O is calculated by the canonical variational transition state theory (CVT) with small curvature tunneling (SCT).	Water	389-392	thiosulfate sulfurtransferase	Homo sapiens	45-48
30960152-0	2019	Mechanical and Water-Resistant Properties of Eco-Friendly Chitosan Membrane Reinforced with Cellulose Nanocrystals.	Water	15-20	ciliogenesis associated kinase 1	Homo sapiens	45-48
30476755-4	2019	Herein, we describe a PNGase activity assay which relies on the conversion of WST-1, a yellowish, water-soluble tetrazolium dye (sodium 2-(4-Iodophenyl)-3-(4-nitro-phenyl)-5-(2,4-disulfophenyl)-2H-tetrazolate), into a blue formazan dye.	Water	98-103	N-glycanase 1	Homo sapiens	22-28
30458105-4	2019	In deionized water, PGlu- b-ELP copolypeptides showed one transition from free soluble chains below the transition temperature ( Tt) of the ELP block to macroscopic aggregates above the Tt.	Water	13-18	nuclear receptor subfamily 5 group A member 1	Homo sapiens	28-31
30458105-7	2019	In addition, 1H NMR and CD experiments revealed, in deionized water, the formation of type II beta-turns into the ELP block upon temperature increase.	Water	62-67	nuclear receptor subfamily 5 group A member 1	Homo sapiens	114-117
30713665-5	2018	As demonstrated by enzyme linked immunosorbent assay and 16S rDNA sequence analysis of stool samples, the consumption of hydrogen-rich water for two months significantly reduced serum malondialdehyde, interleukin-1, interleukin-6, tumour necrosis factor-alpha levels; then significantly increased serum superoxide dismutase, total antioxidant capacity levels and haemoglobin levels of whole blood.	Water	135-140	interleukin 1 alpha	Homo sapiens	201-214
30320948-3	2019	Two isomorphous frameworks [Co4 (MO4 )(eim)6 ] (M=Mo or W, Heim=2-ethylimidazole) having Co(eim)3 (MO4 ) units and high water stabilities were designed and synthesized.	Water	120-125	complement C4A (Rodgers blood group)	Homo sapiens	28-31
29982032-1	2018	In this study, we report for the first time the controlled Co-doping in TiO2 nanowire (NW) arrays grown on the FTO substrate for highly efficient photoelectrochemical (PEC) water splitting.	Water	173-178	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	111-114
30266233-6	2018	Under optimal conditions, the linear responses of the phenylurea pesticides were 0.1-100 ng mL-1 for lake water and 0.5-100 ng g-1 for cucumber and tomato samples.	Water	106-111	L1 cell adhesion molecule	Mus musculus	92-96
30408970-3	2018	We highlight the presence of isomers for the N2O-H2O complex with the help of theoretical calculations at second order Moller-Plesset (MP2) and coupled-cluster single double triple-F12a/aug-cc-pVTZ levels.	Water	49-52	tryptase pseudogene 1	Homo sapiens	135-138
30195263-6	2018	It is hypothesized that the free phosphate group affects the microenvironment around the target cytosine by activating the incoming nucleophile through hydrogen bonding with the water molecule, thus facilitating nucleophilic attack on the cytosine C-4 carbon.	Water	178-183	complement C4A (Rodgers blood group)	Homo sapiens	248-251
28820043-1	2018	Water contamination with chlorinated hydrocarbons such as chloroform (CHCl3), carbon tetrachloride (CCl4) and trichloroethylene (TCE) is one of the major public health concerns.	Water	0-5	C-C motif chemokine ligand 4	Homo sapiens	100-104
30519272-0	2018	The Effects of Radix Astragali Water Abstract on Energy Metabolism in Rat Yang-Deficiency Cold Syndrome Model through PPAR Signaling Pathway.	Water	31-36	peroxisome proliferator activated receptor alpha	Rattus norvegicus	118-122
30351325-3	2018	In this work, air nanobubbles produced in water solution were employed for studying interfacial effects on the self-assembly of a model amyloid peptide termed P11.	Water	42-47	endonuclease, poly(U) specific	Homo sapiens	159-162
30386595-4	2018	Methods: The present study includes the use of HepG2 tumor xenograft model to study the potential role of glucose (by providing 15% glucose via drinking water) in regulating PCSK9 expression and associated hypercholesterolemia.	Water	153-158	proprotein convertase subtilisin/kexin type 9	Mus musculus	174-179
30386595-7	2018	Results: We observed that serum and hepatic PCSK9 level is decreased in mice which were provided with glucose containing water.	Water	121-126	proprotein convertase subtilisin/kexin type 9	Mus musculus	44-49
30386595-8	2018	Interestingly, serum and tumor PCSK9 level was upregulated in HepG2-tumor-bearing mice having access to water containing glucose.	Water	104-109	proprotein convertase subtilisin/kexin type 9	Mus musculus	31-36
30269487-2	2018	Results showed that the ingestion of elastin peptides could obviously ameliorate epidermis hyperplasia and fibroblast apoptosis, and increase the content of hydroxyproline and water in photoaging skin in vivo ( p &lt; 0.05).	Water	176-181	elastin	Mus musculus	37-44
30207701-6	2018	Comparison of the nuCO and nuFe-C values of the heme-DNA complexes with those of myoglobin (Mb) revealed that the donor strength of the axial ligation trans to the CO in a complex is considerably weaker than that of the proximal histidine in Mb, as expected from the coordination of H2O trans to the CO in the complex.	Water	283-286	myoglobin	Homo sapiens	81-90
29920367-2	2018	In this work, a polysaccharide fraction (GLP) was purified from G. lucidum by water extraction and alcohol precipitation.	Water	78-83	euchromatic histone lysine methyltransferase 1	Homo sapiens	41-44
30026092-1	2018	The pH-responsive intelligent drug release facility of hydrophobically modified chitosan nanoparticles (Chit NPs) (d = 5.2 +- 1.1 nm) was presented in the case of poorly water soluble Ca2+ channel blocker nimodipine (NIMO) drug molecules.	Water	170-175	chitinase 1	Homo sapiens	104-108
30026092-4	2018	Hydrophobization of the polymer unambiguously led to lower water contents with lower intermolecular interactions in the prepared hydrogel matrix: the initial hydrophilic Chit has the highest water content (78.6 wt%) and the increasing hydrophobicity of the polymer resulted in decreasing water content (C6-chit.	Water	59-64	chitinase 1	Homo sapiens	170-174
30026092-4	2018	Hydrophobization of the polymer unambiguously led to lower water contents with lower intermolecular interactions in the prepared hydrogel matrix: the initial hydrophilic Chit has the highest water content (78.6 wt%) and the increasing hydrophobicity of the polymer resulted in decreasing water content (C6-chit.	Water	191-196	chitinase 1	Homo sapiens	170-174
30310113-2	2018	Carbon sink assessment scheme based on its forming processes (CSF) is a recently proposed measure but repeatly calculates emission from water erosion and ignored human inducing carbon inputs.	Water	136-141	colony stimulating factor 2	Homo sapiens	62-65
29852990-7	2018	The biosensor may also exhibit good sensitivity for alpha-glucosidase determination with the detection limit 0.005 U/mL and can be reused by water-washing regeneration with good repeatability.	Water	141-146	sucrase-isomaltase	Homo sapiens	52-69
30395885-6	2018	The results indicated that APN treatment reduced infarct volume, neurological deficits and brain water content after I/R injury.	Water	97-102	adiponectin, C1Q and collagen domain containing	Mus musculus	27-30
30403167-2	2018	METHODS: In this study, the water extract of LWDH was tested for its alpha-Amylase and alpha-Glucosidase inhibitory activities, and its anti-diabetic property in streptozotocin (STZ)-induced diabetic mice was also analyzed.	Water	28-33	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
30029355-2	2018	Trace dissolved iron in oceanic surface water can limit phytoplankton growth which in turn limits the carbon dioxide flux at the air/sea interface.	Water	40-45	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	133-136
29959186-6	2018	The results showed that EPO could promote interleukin (IL) 10 (IL-10) expression; inhibit tumor necrosis factor-alpha (TNF-alpha), IL-6, and inducible nitric oxide synthase (iNOS) expressions; reduce the fractional excretion of sodium (FENa) and plasma creatinine (CREA) and urea; and promote the recovery of water and salt handling and AQP2 expression in BUO-R rats, especially in the high dose of EPO-treated group rats.	Water	309-314	erythropoietin	Rattus norvegicus	24-27
30242223-4	2018	The ALSM and ALCM sensor (ALSM and ALCM denotes the devices prepared by coating the ALS and ALC materials with methanol, respectively) fabricated using the sol-gel method and combustion synthesis combined with quasi-MIT exhibit good gas sensing properties to methanol, in contrast with the two devices (ALSW and ALCW denote the devices prepared for coating the ALS and ALC materials with water, respectively) without the use of quasi-MIT.	Water	388-393	allantoicase	Homo sapiens	13-16
30242223-4	2018	The ALSM and ALCM sensor (ALSM and ALCM denotes the devices prepared by coating the ALS and ALC materials with methanol, respectively) fabricated using the sol-gel method and combustion synthesis combined with quasi-MIT exhibit good gas sensing properties to methanol, in contrast with the two devices (ALSW and ALCW denote the devices prepared for coating the ALS and ALC materials with water, respectively) without the use of quasi-MIT.	Water	388-393	allantoicase	Homo sapiens	35-38
30213966-6	2018	The neurophysiological, behavioural and transcriptomic results were consistent: L. salmonis detects Cath-2 as a water-soluble peptide released from the skin of salmon, triggering chemosensory neural activity associated with altered swimming behaviour of copepodids exposed to the peptide, and chemosensory-related genes were up-regulated in copepodids exposed to the peptide.	Water	112-117	cathelicidin antimicrobial peptide	Salmo salar	100-106
30121494-7	2018	Molecular docking studies with 10, a water-soluble analog of 7h, demonstrate that this analog interacts with the dimerization/oligomerization domain of monomeric IKKbeta and may inhibit oligomer formation and subsequent autophosphorylation.	Water	37-42	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	162-169
29982939-9	2018	Mean preoperatively measured CSF pressure was 26.6 cm H2O.	Water	54-57	colony stimulating factor 2	Homo sapiens	29-32
29859956-2	2018	However, there has been no quantitative validation of using dogs to predict the fraction of oral dose absorbed (Fa) in humans (Fah) for poorly water-soluble drugs.	Water	143-148	fumarylacetoacetate hydrolase	Homo sapiens	127-130
30009821-1	2018	AIMS: The aim of the present study was to evaluate the regulation of Aquaporin-2 (AQP2) water channel in the kidney of one-kidney, one-clip rats (Goldblatt-1 model).	Water	88-93	aquaporin 2	Rattus norvegicus	69-80
30009821-1	2018	AIMS: The aim of the present study was to evaluate the regulation of Aquaporin-2 (AQP2) water channel in the kidney of one-kidney, one-clip rats (Goldblatt-1 model).	Water	88-93	aquaporin 2	Rattus norvegicus	82-86
30718974-0	2019	Alteration in Inflammatory Responses and Cytochrome P450 Expression of Porcine Jejunal Cells by Drinking Water Supplements.	Water	105-110	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	41-56
30718974-3	2019	In this study, the effect of four drinking water supplements on CYP mRNA levels of porcine intestinal epithelial cells was examined.	Water	43-48	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	64-67
30009821-6	2018	SIGNIFICANCE: In this model of hypertension the decrease of AQP2 expression could be a mechanism that counteracts the high blood pressure promoting water excretion and this may be consequence of decreased vasopressin sensitivity and/or the increased activity of NFkB at renomedullary collecting duct level.	Water	148-153	aquaporin 2	Rattus norvegicus	60-64
34439058-4	2021	In this study, we used a river water microcosm model to evaluate how Aeromonas spp., an important pathogenic and zoonotic genus ubiquitary in aquatic ecosystems, responds to environmental variations of temperature and pH as expected by future projections.	Water	31-36	histocompatibility minor 13	Homo sapiens	79-82
29660878-8	2018	Consequently, Cd2+ was more efficiently (86%) removed from effluent wastewater than from synthetic wastewater (73%), while its removal from Milli-Q water was inefficient (19%).	Water	73-78	CD2 molecule	Homo sapiens	14-17
30551379-6	2019	Importantly, ZWT increased the expression of Aquaporin-2 (AQP2) which play key roles in maintaining body water homeostasis.	Water	105-110	aquaporin 2	Rattus norvegicus	45-56
30551379-6	2019	Importantly, ZWT increased the expression of Aquaporin-2 (AQP2) which play key roles in maintaining body water homeostasis.	Water	105-110	aquaporin 2	Rattus norvegicus	58-62
29660878-9	2018	The trace amounts of Cd2+ that remained in the remediated water were either dissolved or sorbed to residual nZVI.	Water	58-63	CD2 molecule	Homo sapiens	21-24
34342968-6	2021	Combining what we learned, we achieved a water harvesting efficiency of 17% with an optimized stainless-steel harp, over three times higher than that of the current standard of a Raschel mesh.	Water	41-46	ankyrin repeat and sterile alpha motif domain containing 4B	Homo sapiens	110-114
30230386-7	2019	RESULTS: MME2 composed of oleic acid (5), surfactant mixture (50), water (45), and chitosan (0.5) showed size of 96.45 nm, PDI 0.21 and zeta potential 13.52 mV.	Water	67-72	peptidyl arginine deiminase 1	Homo sapiens	123-126
34260194-3	2021	Typically, within the purification and fabrication steps, chemical solvents, energy-intensive equipment, and large quantities of water are used to reverse engineer silk fibroin into an aqueous solution and then process into the final material format.	Water	129-134	fibroin light chain	Bombyx mori	169-176
30484051-1	2019	During the last six decades, the water level of the Aral Sea, once one of the largest lakes in the world, has experienced a major human-driven regression followed by significant changes in salinity.	Water	33-38	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	57-60
30149526-0	2018	Inhibitory Effect of Opuntia humifusa Fruit Water Extract on Solar Ultraviolet-Induced MMP-1 Expression.	Water	44-49	matrix metallopeptidase 1	Homo sapiens	87-92
30149526-2	2018	In the present study, we aimed to determine whether O. humifusa fruit water extract (OHE) has inhibitory effects against solar ultraviolet (sUV)-induced matrix metalloproteinase-1 (MMP-1) expression.	Water	70-75	matrix metallopeptidase 1	Homo sapiens	181-186
34370622-7	2021	Additionally, MD simulation supports the robust stability of Ochnaflavone and Licoflavone B against NSP9 at the active sites via hydrophobic interactions, H-bonding, and H-bonding facilitated by water.	Water	195-200	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	100-104
30127346-1	2018	Measuring water contents of magmas is fundamental to resolving a number of geological questions, such as the mechanisms of silicic magma evolution, the triggering of volcanic eruptions, and the formation of porphyry copper deposits.	Water	10-15	presequence translocase associated motor 16	Homo sapiens	28-34
30657456-6	2019	The MW-exposed rats with silica-rich water (MW+EW) had lower serum tumor necrosis factor alpha (TNF-alpha) and interleukin 2 (IL-2) levels, but higher IL-10 levels, than MW+SW rats (p &lt; 0.05).	Water	37-42	interleukin 2	Rattus norvegicus	111-124
30657456-6	2019	The MW-exposed rats with silica-rich water (MW+EW) had lower serum tumor necrosis factor alpha (TNF-alpha) and interleukin 2 (IL-2) levels, but higher IL-10 levels, than MW+SW rats (p &lt; 0.05).	Water	37-42	interleukin 2	Rattus norvegicus	126-130
30462987-1	2019	Activation of membrane-associated estrogen receptors (mER) decreases food and water intake in female rats.	Water	78-83	MER proto-oncogene tyrosine kinase	Mus musculus	54-57
34293261-4	2021	This heterogeneous system has been shown to be a powerful and robust molecular hybrid anode for electrocatalytic water oxidation into molecular oxygen, achieving current densities in the range of 200 mA/cm2 at pH 7 under an applied potential of 1.45 V vs NHE.	Water	113-118	solute carrier family 9 member C1	Homo sapiens	255-258
29979588-2	2018	In this work, we focus on the conjugation of amphiphilic variants of elastin-like polypeptide (ELP), short elastin (sEL), to poorly water-soluble compounds like OPPVs ( p-phenylenevinylene oligomers), triarylamines, and polypyridine-metal complexes.	Water	132-137	nuclear receptor subfamily 5 group A member 1	Homo sapiens	69-93
29979588-2	2018	In this work, we focus on the conjugation of amphiphilic variants of elastin-like polypeptide (ELP), short elastin (sEL), to poorly water-soluble compounds like OPPVs ( p-phenylenevinylene oligomers), triarylamines, and polypyridine-metal complexes.	Water	132-137	nuclear receptor subfamily 5 group A member 1	Homo sapiens	95-98
30462987-5	2019	To address these open questions, we first showed that activation of mER in the mPOA decreased both overnight food and water intake, and did so in a time course consistent with a genomic mechanism of action.	Water	118-123	MER proto-oncogene tyrosine kinase	Mus musculus	68-71
34393560-8	2021	nov. adds to the Rapa Nui ichthyofauna, which hosts the second-highest level of endemism in both shallow and deep-water fishes.	Water	114-119	transcriptional regulating factor 1	Homo sapiens	17-21
33623182-2	2019	As a critical model input, spatiotemporally varying nodal water demands significantly affect the performance and applicability of such WDS models.	Water	58-63	nodal growth differentiation factor	Homo sapiens	52-57
33623182-5	2019	To address the difficulty, this study proposes a formal Bayesian approach to determine nodal demands in WDS hydraulic modeling by explicitly taking prior water demand information into account and coupling more information to constrain the nodal water demand modeling.	Water	154-159	nodal growth differentiation factor	Homo sapiens	87-92
29852188-6	2018	For this, Wistar rats were treated with metformin 293 mg/kg/day (MET) or water (CTR) by gavage during the gestational period.	Water	73-78	calcitonin receptor	Rattus norvegicus	80-83
30062333-2	2018	In this study, to understand the thermal behavior of the material, molecular dynamics was utilized to investigate the molecular structure, dynamic property, and mechanical behavior of NASH gel subjected to temperature elevation from 300 K to 1500 K. The aluminosilicate skeleton in NASH gel provides plenty of oxygen sites to accept H-bond from the invading water molecules.	Water	358-363	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	184-188
30062333-2	2018	In this study, to understand the thermal behavior of the material, molecular dynamics was utilized to investigate the molecular structure, dynamic property, and mechanical behavior of NASH gel subjected to temperature elevation from 300 K to 1500 K. The aluminosilicate skeleton in NASH gel provides plenty of oxygen sites to accept H-bond from the invading water molecules.	Water	358-363	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	282-286
30062333-6	2018	Furthermore, the self-diffusivity of water molecules and sodium dramatically increases with the elevation of temperature, because the decrease in connectivity of the aluminosilicate network reduces the chemical and geometric restriction on the water and ions in NASH gel under higher temperatures.	Water	37-42	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	262-266
33623182-5	2019	To address the difficulty, this study proposes a formal Bayesian approach to determine nodal demands in WDS hydraulic modeling by explicitly taking prior water demand information into account and coupling more information to constrain the nodal water demand modeling.	Water	245-250	nodal growth differentiation factor	Homo sapiens	87-92
33623182-5	2019	To address the difficulty, this study proposes a formal Bayesian approach to determine nodal demands in WDS hydraulic modeling by explicitly taking prior water demand information into account and coupling more information to constrain the nodal water demand modeling.	Water	245-250	nodal growth differentiation factor	Homo sapiens	239-244
30062333-6	2018	Furthermore, the self-diffusivity of water molecules and sodium dramatically increases with the elevation of temperature, because the decrease in connectivity of the aluminosilicate network reduces the chemical and geometric restriction on the water and ions in NASH gel under higher temperatures.	Water	244-249	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	262-266
34423202-10	2021	Relative permeability experiments show that water drive permeability at the isopermeability point is (0.049 10-3 mum2) higher than that of gas drive (0.041 10-3 mum2).	Water	44-49	trafficking protein particle complex subunit 1	Homo sapiens	113-117
30062333-12	2018	However, the ductility of the NASH gel is improved because of the higher extent of structural arrangement at the yield stage and partly due to the lower water attack.	Water	153-158	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	30-34
34423202-10	2021	Relative permeability experiments show that water drive permeability at the isopermeability point is (0.049 10-3 mum2) higher than that of gas drive (0.041 10-3 mum2).	Water	44-49	trafficking protein particle complex subunit 1	Homo sapiens	161-165
31291624-1	2019	BACKGROUND: This review considers anew the etiology of the cardio-renal protective effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors by extending the discussion to renal congestion, inherent in diabetic kidney disease (DKD) even at an early stage of nephropathy in which heart failure (HF) or salt and water accumulation is asymptomatic.	Water	312-317	solute carrier family 5 member 2	Homo sapiens	93-123
31291624-1	2019	BACKGROUND: This review considers anew the etiology of the cardio-renal protective effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors by extending the discussion to renal congestion, inherent in diabetic kidney disease (DKD) even at an early stage of nephropathy in which heart failure (HF) or salt and water accumulation is asymptomatic.	Water	312-317	solute carrier family 5 member 2	Homo sapiens	125-130
30185991-7	2018	In the hot inner regions, H2O, and simple organic molecules like C2H2, HCN, and CH4 are predicted to be very abundant in T Tauri disks and even more in Herbig Ae/Be disks, in contrast with infrared observations that find a much lower detection rate of water and simple organics toward disks around hotter stars.	Water	252-257	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	71-74
34060391-9	2021	Furthermore, we demonstrated that knockdown of miR-379-5p significantly reversed the increased clinical scores and inflammatory response resulting from EAU treatment and this effect was further countervailed by SEMA3A silencing.	Water	152-155	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	211-217
31459000-1	2018	A new water-soluble reactive perylene tetracarboxylic diimide derivative (PDI-pfp) is designed and synthesized that can realize fast imaging of the endoplasmic reticulum in living cells.	Water	6-11	peptidyl arginine deiminase 1	Homo sapiens	74-77
31459000-2	2018	The PDI-pfp comprises three functional moieties: perylene tetracarboxylic diimide as fluorescent backbone, poly(ethylene glycol) for providing good water disperse ability, and pentafluorophenol active ester as the reactive group under physiological condition.	Water	148-153	peptidyl arginine deiminase 1	Homo sapiens	4-7
31291624-4	2019	I hypothesize that SGLT2 inhibitors cause a shift in extracellular water from the IF space to the intravascular space to compensate for the SGLT2 inhibitor-induced hypovolemia.	Water	67-72	solute carrier family 5 member 2	Homo sapiens	19-24
31291624-4	2019	I hypothesize that SGLT2 inhibitors cause a shift in extracellular water from the IF space to the intravascular space to compensate for the SGLT2 inhibitor-induced hypovolemia.	Water	67-72	solute carrier family 5 member 2	Homo sapiens	140-145
30660263-0	2019	Microplastic content variation in water column: The observations employing a novel sampling tool in stratified Baltic Sea.	Water	34-39	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	118-121
34251523-1	2021	A multiple linear regression model called MLR-3 is used for predicting the experimental n-octanol/water partition coefficient (log PN) of 22 N-sulfonamides proposed by the organizers of the SAMPL7 blind challenge.	Water	98-103	CD69 molecule	Homo sapiens	42-47
30660263-2	2019	It can collect several cubic meters of water from predefined water layers down to 100 m. The tool was tested in the Baltic Sea during the period of spring thermocline formation.	Water	39-44	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	123-126
29446985-3	2018	In (2), CE water was more enriched than PWS-extracted water, with a MAD respect to source water of roughly 8 % for delta2H and 4 % for delta18O.	Water	11-16	delta like canonical Notch ligand 4	Homo sapiens	115-128
29108726-3	2018	The spatial-temporal changes in the 239,240Pu distribution as well as effective half-life for these radionuclides in the Black Sea surface water in deep-sea area are presented.	Water	139-144	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	127-130
30660263-2	2019	It can collect several cubic meters of water from predefined water layers down to 100 m. The tool was tested in the Baltic Sea during the period of spring thermocline formation.	Water	61-66	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	123-126
29108726-3	2018	The spatial-temporal changes in the 239,240Pu distribution as well as effective half-life for these radionuclides in the Black Sea surface water in deep-sea area are presented.	Water	139-144	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	153-156
34251523-4	2021	Overall, the results support the appropriateness of multiple linear regression approach MLR-3 for computing the n-octanol/water partition coefficient in sulfonamide-bearing compounds.	Water	122-127	CD69 molecule	Homo sapiens	88-93
30660291-0	2019	Bioavailability and distribution of PAHs and PCBs in the sediment pore water of the German Bight and Wadden Sea.	Water	71-76	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	108-111
34096052-10	2021	Relative to students with higher HL, students with lower HL reported significantly lower frequency of health-promoting behaviors (water, fruit and vegetable intake, physical activity, sleep), higher frequency of risky health behaviors (sugar-sweetened beverages, junk food, screen time), and had higher BMI percentiles and lower QOL (all p < .05).	Water	130-135	lipase C, hepatic type	Homo sapiens	57-59
30713826-0	2018	Forced diffusion of water molecules through aquaporin-5 biomembrane; a molecular dynamics study.	Water	20-25	aquaporin 5	Homo sapiens	44-55
30713826-4	2018	We have adopted Molecular Dynamics (MD) simulation to analyze the water permeation and diffusion in AQP5 structure in a 0.5 microsecond simulation time window.	Water	66-71	aquaporin 5	Homo sapiens	100-104
30713826-5	2018	The MD numerical simulation shows the water permeability of the human AQP5 is in the nominal range for other members of human aquaporins family.	Water	38-43	aquaporin 5	Homo sapiens	70-74
30713826-9	2018	Finally, it is revealed that the MD simulation of human AQP5 provides useful insights into the mechanisms of water regulation through alveolar cells under the different physical conditions; osmotic self-diffusion and forced diffusion condition.	Water	109-114	aquaporin 5	Homo sapiens	56-60
30398300-0	2018	Confined Pt1 1+ Water Clusters in a MOF Catalyze the Low-Temperature Water-Gas Shift Reaction with both CO2 Oxygen Atoms Coming from Water.	Water	16-21	zinc finger protein 77	Homo sapiens	9-12
30461273-9	2018	Therefore, the present results suggest that trehalose will restore the tightly bound water molecules around the hotspot (G-helix) of myoglobin on the amyloid transition by its intrinsic preservative action of the native hydration shell against denaturation.	Water	85-90	myoglobin	Homo sapiens	133-142
30572630-0	2018	Gi Protein Modulation of the Potassium Channel TASK-2 Mediates Vesicle Osmotic Swelling to Facilitate the Fusion of Aquaporin-2 Water Channel Containing Vesicles.	Water	128-133	aquaporin 2	Homo sapiens	116-127
30572630-4	2018	We report the first example that non-secretory vesicles, committed to insert the Aquaporin-2 water channel into the plasma membrane, swell and this phenomenon is required for fusion to plasma membrane.	Water	93-98	aquaporin 2	Homo sapiens	81-92
30074283-1	2018	LaNiO3 /CdS heterojunction photocatalysts are constructed by compositing LaNiO3 nanoparticles with commercially available CdS, and are used for efficient photocatalytic splitting of H2 O with visible light.	Water	182-186	CDP-diacylglycerol synthase 1	Homo sapiens	8-11
30074283-1	2018	LaNiO3 /CdS heterojunction photocatalysts are constructed by compositing LaNiO3 nanoparticles with commercially available CdS, and are used for efficient photocatalytic splitting of H2 O with visible light.	Water	182-186	CDP-diacylglycerol synthase 1	Homo sapiens	122-125
30517197-1	2018	BACKGROUND: Aquaporin 5 (AQP5) expression impacts on cellular water transport, renal function but also on key mechanisms of inflammation and immune cell migration that prevail in sepsis and ARDS.	Water	62-67	aquaporin 5	Homo sapiens	12-23
30517197-1	2018	BACKGROUND: Aquaporin 5 (AQP5) expression impacts on cellular water transport, renal function but also on key mechanisms of inflammation and immune cell migration that prevail in sepsis and ARDS.	Water	62-67	aquaporin 5	Homo sapiens	25-29
30622665-12	2018	Filtered water treatment restored the activity of antioxidant enzymes, downregulated ET-1, and Ang II in the serum of mice.	Water	9-14	endothelin 1	Mus musculus	85-89
29931162-6	2018	These results demonstrate the ability of an estrogen receptor agonist to disrupt sexual development in both male and female mice, even at a low dose, administered via drinking water.	Water	176-181	estrogen receptor 1 (alpha)	Mus musculus	44-61
30245232-4	2018	In this study, the use of unnatural amino acid substituted IKKbeta with unique photophysical activity to sense water environment changes upon interaction with NEMO provides a powerful in vitro screening platform that would greatly facilitate the identification of compounds having the potential to disrupt IKKbeta-NEMO interaction, and thus specifically modulate the canonical NF-kappaB pathway.	Water	111-116	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	59-66
30245232-4	2018	In this study, the use of unnatural amino acid substituted IKKbeta with unique photophysical activity to sense water environment changes upon interaction with NEMO provides a powerful in vitro screening platform that would greatly facilitate the identification of compounds having the potential to disrupt IKKbeta-NEMO interaction, and thus specifically modulate the canonical NF-kappaB pathway.	Water	111-116	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	159-163
30245232-4	2018	In this study, the use of unnatural amino acid substituted IKKbeta with unique photophysical activity to sense water environment changes upon interaction with NEMO provides a powerful in vitro screening platform that would greatly facilitate the identification of compounds having the potential to disrupt IKKbeta-NEMO interaction, and thus specifically modulate the canonical NF-kappaB pathway.	Water	111-116	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	306-313
30245232-4	2018	In this study, the use of unnatural amino acid substituted IKKbeta with unique photophysical activity to sense water environment changes upon interaction with NEMO provides a powerful in vitro screening platform that would greatly facilitate the identification of compounds having the potential to disrupt IKKbeta-NEMO interaction, and thus specifically modulate the canonical NF-kappaB pathway.	Water	111-116	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	314-318
30503462-5	2018	The model suggests that microplastics distribution within the Bohai Sea both in the water and on the bottom varies seasonally with wind and currents and depends on a complex interaction between source locations, prevailing hydrodynamic conditions, degradation, settling and resuspension rates.	Water	84-89	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	68-71
30209742-0	2018	Lipase immobilization on high water adsorbing capacity bagasse: applications in bio-based plasticizer synthesis.	Water	30-35	PAN0_003d1715	Moesziomyces antarcticus	0-6
30533410-0	2018	Adsorption Properties and Mechanism of Cd2+ in Water by Zr-containing Silica Residue Purification.	Water	47-52	CD2 molecule	Homo sapiens	39-42
30296106-6	2018	A controlled study of the pre-electrodeposited copper surface indicates that the formation of a 5-8 nm thick LiF protective layer on copper substrate from a chemical reaction between adsorbed surface water layer in acidic solutions and LiPF6 electrolyte is the key process in the electrochemical growth of lithium columns.	Water	200-205	LIF interleukin 6 family cytokine	Homo sapiens	109-112
30423876-6	2018	In produced water of crude oil, SAN/PANI/FLG reduced the corrosion up to 95% while ZnO/GO suppressed the corrosion up to 10%.	Water	12-17	filaggrin	Homo sapiens	41-44
30360051-4	2018	For PCN-250 frameworks, H2O molecule induces a remarkable increase in the CO2 uptake for the dynamic CO2 capture from CO2/N2 (15:85) mixture.	Water	24-27	complement C2	Homo sapiens	118-124
30257090-6	2018	The membranes also show pure water permeance as high as 80 L m-2 h-1 bar-1, which is about 8 times that of commercial NF 90 membrane and 2 times that of a commercial ultrafiltration membrane (with a molecular weight cutoff of 2000 Da), rendering their promise for practical dye desalination.	Water	29-34	interleukin enhancer binding factor 3	Homo sapiens	118-123
30238677-1	2018	A palladium phosphide electrocatalyst supported on carbon black (PdP2 @CB) shows efficient water splitting in both alkaline and neutral electrolytes.	Water	91-96	pyruvate dehydrogenase phosphatase catalytic subunit 2	Homo sapiens	65-69
30238677-5	2018	1.59 V and 1.72 V are needed for PdP2 @CB to achieve stable water splitting catalytic current density of 10 mA cm-2 in 1 m PBS and 50 mA cm-2 in 1 m KOH for 10 h, respectively.	Water	60-65	pyruvate dehydrogenase phosphatase catalytic subunit 2	Homo sapiens	33-37
30410770-12	2018	A best evidence analysis demonstrated a strong association between cold water immersion and in increases of CVP (central venous pressure), MPAP (mean pulmonary arterial pressure), PVR (peripheral vascular resistance) and PAWP (pulmonary arterial wedge pressure) resulting in interstitial asymptomatic oedema.	Water	72-77	PVR cell adhesion molecule	Homo sapiens	180-183
30031346-2	2018	The results show that the RCFA can introduce COD (14, 4, and 11 mg L-1 at pH = 1.0, 7.0, and 14.0, respectively) into water due to the dissolution of reductive components from RCFA, this can be avoided by washing (6 times) using distilled water.	Water	118-123	l(1)L1	Drosophila melanogaster	67-70
30096472-2	2018	Zein is a water-insoluble amphiphilic protein obtained from the corn.	Water	10-15	zein	Zea mays	0-4
30082155-0	2018	Occurrence of microplastics in the water column and sediment in an inland sea affected by intensive anthropogenic activities.	Water	35-40	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	74-77
30188995-6	2018	Metatranscriptomic analyses of this metabolic pathway in the water column of the Red Sea revealed that the corresponding genes were constitutively transcribed, independent of depth and light, suggesting that osmoregulation using glucosylglycerol is a general feature of HL II Prochlorococcus in the Red Sea.	Water	61-66	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
30188995-6	2018	Metatranscriptomic analyses of this metabolic pathway in the water column of the Red Sea revealed that the corresponding genes were constitutively transcribed, independent of depth and light, suggesting that osmoregulation using glucosylglycerol is a general feature of HL II Prochlorococcus in the Red Sea.	Water	61-66	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	303-306
30806622-3	2018	The present study also prepared and evaluated cream mask from mixture of seaweeds extracted with water.	Water	97-102	ankyrin repeat and KH domain containing 1	Homo sapiens	52-56
30037400-8	2018	Because of high cytotoxicity, the mutagenic potential of water samples from the Jialu River (SM-1 water samples) was not significantly enhanced compared with that of untreated controls.	Water	57-62	SM1	Homo sapiens	93-97
29803921-1	2018	Diffusion MRI (dMRI) provides the ability to reconstruct neuronal fibers in the brain, in vivo, by measuring water diffusion along angular gradient directions in q-space.	Water	109-114	mrityu	Drosophila melanogaster	15-19
29524896-0	2018	Water quality assessment and catchment-scale nutrient flux modeling in the Ramganga River Basin in north India: An application of INCA model.	Water	0-5	caspase recruitment domain family member 17	Homo sapiens	130-134
30012618-0	2018	MIZ1 regulates ECA1 to generate a slow, long-distance phloem-transmitted Ca2+ signal essential for root water tracking in Arabidopsis.	Water	104-109	MIZU-KUSSEI-like protein (Protein of unknown function, DUF617)	Arabidopsis thaliana	0-4
30012618-0	2018	MIZ1 regulates ECA1 to generate a slow, long-distance phloem-transmitted Ca2+ signal essential for root water tracking in Arabidopsis.	Water	104-109	ER-type Ca2+-ATPase 1	Arabidopsis thaliana	15-19
30012618-3	2018	In addition, the MIZ1 protein, whose biochemical function is unknown but is required for root curvature toward water, is indispensable for generating the slow, long-distance Ca2+ signal.	Water	111-116	MIZU-KUSSEI-like protein (Protein of unknown function, DUF617)	Arabidopsis thaliana	17-21
30012618-4	2018	Furthermore, biochemical and genetic manipulations that elevate cytosolic Ca2+ levels, including mutants of the endoplasmic reticulum (ER) Ca2+-ATPase isoform ECA1, enhance root curvature toward water.	Water	195-200	ER-type Ca2+-ATPase 1	Arabidopsis thaliana	159-163
30012618-6	2018	We suggest that the inhibition of ECA1 by MIZ1 changes the balance between cytosolic Ca2+ influx and efflux and generates the cytosolic Ca2+ signal required for water tracking.	Water	161-166	ER-type Ca2+-ATPase 1	Arabidopsis thaliana	34-38
30012618-6	2018	We suggest that the inhibition of ECA1 by MIZ1 changes the balance between cytosolic Ca2+ influx and efflux and generates the cytosolic Ca2+ signal required for water tracking.	Water	161-166	MIZU-KUSSEI-like protein (Protein of unknown function, DUF617)	Arabidopsis thaliana	42-46
29915836-16	2018	ACL is therefore a direct precursor of ACR in natural surface water.	Water	62-67	acrosin	Homo sapiens	39-42
30079347-3	2018	The Morris water maze and Y-maze test results showed that eight weeks of intragastric administration of LIG (10 mg/kg, 40 mg/kg) every day improved memory deficit in APP/PS1 mice.	Water	11-16	ubiquitin-conjugating enzyme E2K	Mus musculus	104-107
30004404-0	2018	Plasmonic Sensor Based on Interaction between Silver Nanoparticles and Ni2+ or Co2+ in Water.	Water	87-92	complement C2	Homo sapiens	79-82
29620250-4	2018	Effects of PMR water extract on receptor activator of nuclear factor-kB ligand (RANKL)-induced osteoclast differentiation and survival of mouse bone marrow macrophages (BMMs) obtained from femurs were investigated by tartrate-acid resistant acid phosphatase (TRAP)-positive cells and XTT assay.	Water	15-20	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	32-78
29620250-4	2018	Effects of PMR water extract on receptor activator of nuclear factor-kB ligand (RANKL)-induced osteoclast differentiation and survival of mouse bone marrow macrophages (BMMs) obtained from femurs were investigated by tartrate-acid resistant acid phosphatase (TRAP)-positive cells and XTT assay.	Water	15-20	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	80-85
29541861-14	2018	Furthermore, euhydration by water loading caused hyponatremina in Msn -/y mice, suggesting that dysfunction of moesin is associated with the nephrogenic syndrome of inappropriate antidiuresis (NSIAD).	Water	28-33	moesin	Mus musculus	66-69
29541861-14	2018	Furthermore, euhydration by water loading caused hyponatremina in Msn -/y mice, suggesting that dysfunction of moesin is associated with the nephrogenic syndrome of inappropriate antidiuresis (NSIAD).	Water	28-33	moesin	Mus musculus	111-117
29869494-5	2018	Importantly, the COP probes show high stability and could successfully achieve the fluorescence imaging for LFPs after aged for 45 days or washed by water.	Water	149-154	caspase recruitment domain family member 16	Homo sapiens	17-20
29963625-2	2018	It is occupied, almost homogeneously from the subsurface (~137 to 300 m) to depths over 2000 m, by a warm (~21.5 C) and highly saline (~40.5) water mass, referred to as the Red Sea Deep Water (RSDW).	Water	142-147	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	177-180
29963625-2	2018	It is occupied, almost homogeneously from the subsurface (~137 to 300 m) to depths over 2000 m, by a warm (~21.5 C) and highly saline (~40.5) water mass, referred to as the Red Sea Deep Water (RSDW).	Water	186-191	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	177-180
29963625-6	2018	Consequently, significant deep water formation events occurred in the Red Sea in the winters following the 1982 El Chichon eruption in Mexico and the 1991 Mount Pinatubo eruption in the Philippines and during the strong positive phase of the NAO in the winter of 1989.	Water	31-36	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	74-77
29775936-4	2018	The X-ray crystallography complemented by the isothermal titration calorimetry studies revealed the binding mode of this series of inhibitors and the pivotal network of ordered water molecules in the binding pocket of FABP4.	Water	177-182	fatty acid binding protein 4, adipocyte	Mus musculus	218-223
29761810-4	2018	The data indicate a strong interaction of the confined complexes with the lamellae, resulting in a restriction of the local rotational dynamics and of the exchange process of water molecules between the inner coordination sphere of Gd3+ and the bulk.	Water	175-180	GRDX	Homo sapiens	232-235
29789818-1	2018	The interaction of the superalkali cation Li3+ with water molecules, as well as the structures and stability of the resulting water complexes are theoretically studied at the MP2/6-311++G(d,p) level.	Water	126-131	tryptase pseudogene 1	Homo sapiens	175-178
29808402-2	2018	These chemicals may enter into the sea by means of production water (PW), the main discharge derived from oil and gas offshore platforms.	Water	62-67	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	35-38
28987813-11	2018	The radionuclides distribution in the depth profiles shows how contaminated water affects the sediment as it passes sampling stations according to the current circulation pattern in the Baltic Sea.	Water	76-81	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	193-196
29573813-5	2018	Multiple doses of NPY stimulated water intake, but when food was not available, water intake was not affected.	Water	33-38	neuropeptide Y	Homo sapiens	18-21
29420944-8	2018	The method is characterized by excellent enrichment factor of 972, detection limit of 0.045 ng mL-1 and can be successfully applied in analysis of high salinity water, which is difficult to analyze by other spectroscopy techniques.	Water	161-166	L1 cell adhesion molecule	Mus musculus	95-99
30333657-7	2018	The 10 kDa EPH had the highest emulsifying stability index and water holding capacity at all pH levels.	Water	63-68	EPH receptor A1	Homo sapiens	11-14
34218090-1	2021	Bank filtration is a cost-effective and sustainable method of improving surface water quality for drinking water production.	Water	80-85	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	0-4
34218090-1	2021	Bank filtration is a cost-effective and sustainable method of improving surface water quality for drinking water production.	Water	107-112	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	0-4
34590569-0	2021	(Evaluation of extravascular lung water in patients with acute respiratory distress syndrome by syndecan-1 combined with lung ultrasonography).	Water	34-39	syndecan 1	Homo sapiens	96-106
29797427-0	2018	Aquaporin-2 plays an important role in water transportation through the bladder wall in rats.	Water	39-44	aquaporin 2	Rattus norvegicus	0-11
29797427-10	2018	Aquaporin-2 plays an important role in the transport of water, accompanied by sodium concentration change.	Water	56-61	aquaporin 2	Rattus norvegicus	0-11
34590569-1	2021	OBJECTIVE: To investigate the value of plasma syndecan-1 (SDC-1) combined with lung ultrasonography in evaluating the degree of extravascular lung water in patients with acute respiratory distress syndrome (ARDS).	Water	147-152	syndecan 1	Homo sapiens	46-56
30541648-17	2018	With the increase in LPS dosage, the concentration of extracellular ATP in BALF was increased, the concentration of intracellular ATP was decreased, the water containing ratio of lung tissue was increased gradually, and the protein and mRNA expressions of Pannexin-1, P2X7 receptor, caspase-1 and IL-1beta in lung tissue were increased gradually in a dose-dependent manner.	Water	153-158	pannexin 1	Mus musculus	256-266
34590569-1	2021	OBJECTIVE: To investigate the value of plasma syndecan-1 (SDC-1) combined with lung ultrasonography in evaluating the degree of extravascular lung water in patients with acute respiratory distress syndrome (ARDS).	Water	147-152	syndecan 1	Homo sapiens	58-63
34590569-18	2021	Combining the number of B-lines with SDC-1 could further improve the predictive value of pulmonary water in patients with ARDS.	Water	99-104	syndecan 1	Homo sapiens	37-42
34590569-20	2021	CONCLUSIONS: The level of plasma SDC-1 and the number of pulmonary ultrasonic B-lines have a good correlation with the degree of extravascular lung water in patients with ARDS.	Water	148-153	syndecan 1	Homo sapiens	33-38
29958959-8	2018	RESULTS: The LEP showed an interesting water-holding capacity and effective foaming and emulsifying properties.	Water	39-44	leptin	Mus musculus	13-16
34228431-0	2021	Effect of Water Molecules on the Activating S810L Mutation of the Mineralocorticoid Receptor.	Water	10-15	nuclear receptor subfamily 3 group C member 2	Homo sapiens	66-92
34287741-3	2022	Rice isa1 (sug-1) mutants in japonica cultivar with less-active starch synthase IIa (SSIIa) and low granule-bound SSI (GBSSI) expression display wrinkled seed phenotype by accumulating water-soluble phytoglycogen instead of insoluble amylopectin.	Water	185-190	isoamylase 1, chloroplastic	Oryza sativa Japonica Group	5-9
29729254-9	2018	Our results show that physical exercise prevented the Abeta-induced cognitive deficits in object recognition task and the Morris water maze.	Water	129-134	amyloid beta (A4) precursor protein	Mus musculus	54-59
30026092-4	2018	Hydrophobization of the polymer unambiguously led to lower water contents with lower intermolecular interactions in the prepared hydrogel matrix: the initial hydrophilic Chit has the highest water content (78.6 wt%) and the increasing hydrophobicity of the polymer resulted in decreasing water content (C6-chit.	Water	191-196	chitinase 1	Homo sapiens	170-174
30026092-9	2018	Next the poorly water soluble NIMO drug was encapsulated with the C6-chit with adequate pH-sensitive properties.	Water	16-21	chitinase 1	Homo sapiens	69-73
34293887-2	2021	The observed patterns of transitions are consistent with the most stable geometries of the TMO-w, TMO-(w)2, and TMS-w complexes at the B2PLYP-D3(BJ)/aug-cc-pVTZ level and were confirmed using spectra of the 18O isotopologue.	Water	116-117	tms	None	112-115
34237044-1	2021	CASE: We present a series of 3 pelvic ring injuries that occurred on 1 high-speed water slide at a theme park in Orlando, FL.	Water	82-87	fms related receptor tyrosine kinase 3 ligand	Homo sapiens	122-124
30208709-6	2018	The spectra of TrpH+(H2O) m=1,2, recorded by infrared multiphoton dissociation (IRMPD), reveal broad features in the NH stretching region of the NH3+ group, indicating strong hydrogen bonding in acceptor-donor configuration with the benzene ring for the first water molecule, while the second water appears to attach to a less strongly perturbing site, yielding unique transitions associated with the free OH stretching fundamentals.	Water	21-24	tryptophan hydroxylase 1	Homo sapiens	15-19
30208709-6	2018	The spectra of TrpH+(H2O) m=1,2, recorded by infrared multiphoton dissociation (IRMPD), reveal broad features in the NH stretching region of the NH3+ group, indicating strong hydrogen bonding in acceptor-donor configuration with the benzene ring for the first water molecule, while the second water appears to attach to a less strongly perturbing site, yielding unique transitions associated with the free OH stretching fundamentals.	Water	260-265	tryptophan hydroxylase 1	Homo sapiens	15-19
34298909-3	2021	Simulations of the WT P2X4R head domain revealed a flexible coordination sphere dominated by an octahedral geometry encompassing C126, N127, C132, C149, C159 and a water molecule.	Water	164-169	purinergic receptor P2X 4	Homo sapiens	22-27
30208709-6	2018	The spectra of TrpH+(H2O) m=1,2, recorded by infrared multiphoton dissociation (IRMPD), reveal broad features in the NH stretching region of the NH3+ group, indicating strong hydrogen bonding in acceptor-donor configuration with the benzene ring for the first water molecule, while the second water appears to attach to a less strongly perturbing site, yielding unique transitions associated with the free OH stretching fundamentals.	Water	293-298	tryptophan hydroxylase 1	Homo sapiens	15-19
30291170-7	2018	We propose that the water surface of F-actin acts as a low-binding energy, directional waveguide which is recognized specifically by the myosin lever-arm domain before the system engages to form the tight-binding actomyosin complex.	Water	20-25	myosin heavy chain 14	Homo sapiens	137-143
30291170-8	2018	Such a water-mediated recognition process between actin and myosin would enable symmetry breaking through fast, low energy initial binding events.	Water	7-12	myosin heavy chain 14	Homo sapiens	60-66
34226665-9	2022	We demonstrated that Pyk2 inhibition contributes to the long-term cerebrovascular recovery assessed by laser speckle contrast imaging, but cognitive function was not obviously improved as evaluated in Morris water maze and novel object recognition tests.	Water	208-213	PTK2 protein tyrosine kinase 2 beta	Mus musculus	21-25
34281190-9	2021	Furthermore, supraoptic nucleus DeltaN-TRPV1 mRNA expression was not different between non-pregnant and late-pregnant rats, suggesting that sustained activity of DeltaN-TRPV1 channels might maintain vasopressin neuron activity to increase water retention during pregnancy and lactation.	Water	239-244	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	169-174
30286809-0	2018	Therapeutic and immunoregulatory effects of water-soluble alkaloids E2-a from Sophora moorcroftiana seeds as a novel potential agent against echinococcosis in experimentally protoscolex-infected mice.	Water	44-49	transcription factor 3	Mus musculus	68-72
30286809-4	2018	Low polarity compounds (E2-a) were isolated from water-soluble alkaloid (E2) and matrine and sophocarpine were identified as major components.	Water	49-54	transcription factor 3	Mus musculus	24-28
34120412-5	2021	Biochemical analysis and Morris water maze methods were used to elaborate the mechanism of SENP1 in IH impairment.	Water	32-37	SUMO1/sentrin specific peptidase 1	Mus musculus	91-96
30239541-4	2018	The results reported herein from density functional theory (M05-2X) and ab initio (MP2 and CCSD(T)) calculations demonstrate that both the coordination number and the molecular geometry have a sizable impact on the binding strength, deprotonation energy, and acidity of the Zn(ii) coordinated water.	Water	293-298	tryptase pseudogene 1	Homo sapiens	83-86
31595734-6	2018	Moreover, IGF-1 exerted an antioxidant effect revealed by a significant reduction in H2O2 production accompanied by an increase in SOD activity.	Water	85-89	insulin-like growth factor 1	Rattus norvegicus	10-15
34127521-4	2021	In this study, we show that the A2AR antagonist SCH 58261 (SCH) effectively modulates aberrant Th17 responses in induced EAU.	Water	121-124	adenosine A2a receptor	Mus musculus	32-36
30271659-7	2018	Plasma vasopressin levels were on average about 3-fold higher than normal levels, suggesting that the water loss resulted from unresponsiveness of the collecting tubules towards vasopressin, and indeed aquaporin-2 immunofluorescence in collecting tubules was diminished, whereas renal and hypothalamic vasopressin were increased, the latter in spite of substantial astrogliosis in the hypothalamus.	Water	102-107	aquaporin 2	Mus musculus	202-213
34235263-4	2021	This new configuration adds the potential arising from the pH difference across the membrane and enables an open circuit voltage of ~1.6 V. In contrast, the same redox molecules operating at a single pH generate ~0.9 V. Ion transport in the BPM is coupled to the water dissociation and acid-base neutralization reactions.	Water	263-268	phenylalanine hydroxylase	Homo sapiens	59-61
29846108-0	2018	MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis.	Water	22-27	microRNA 132	Mus musculus	0-12
29846108-0	2018	MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis.	Water	22-27	methyl CpG binding protein 2	Mus musculus	59-64
29846108-1	2018	Fine-tuning of the body"s water balance is regulated by vasopressin (AVP), which induces the expression and apical membrane insertion of aquaporin-2 water channels and subsequent water reabsorption in the kidney.	Water	26-31	aquaporin 2	Mus musculus	137-148
29678107-3	2018	The SANS studies show that 1,3-bis(caprolactamyl)butane is a good model for polyvinylcaprolactam, and both the polymer and model compound exhibit hydrogen bonding interactions with water but do not interact significantly with 2-butoxyethanol in aqueous solution.	Water	181-186	USH1 protein network component sans	Homo sapiens	4-8
29501970-3	2018	In this study, by coating uniformly sized GNRs with MSN in an oil-water biphase reaction system, we have successfully synthesized a new bacteria-like GNR@MSN (i.e., bGNR@MSN) with a significantly enlarged pore size (4-8 nm) and surface area (470 m2/g).	Water	66-71	moesin	Mus musculus	52-55
29501970-3	2018	In this study, by coating uniformly sized GNRs with MSN in an oil-water biphase reaction system, we have successfully synthesized a new bacteria-like GNR@MSN (i.e., bGNR@MSN) with a significantly enlarged pore size (4-8 nm) and surface area (470 m2/g).	Water	66-71	moesin	Mus musculus	150-157
29501970-3	2018	In this study, by coating uniformly sized GNRs with MSN in an oil-water biphase reaction system, we have successfully synthesized a new bacteria-like GNR@MSN (i.e., bGNR@MSN) with a significantly enlarged pore size (4-8 nm) and surface area (470 m2/g).	Water	66-71	moesin	Mus musculus	154-157
30063889-5	2018	FT-IR revealed that the salt, in combination with the hydrophilic silica, trapped water that provided a repulsive surface to the hydrophobic ELP and forced the ELP to continuously minimize its surface area until the water evaporated.	Water	82-87	nuclear receptor subfamily 5 group A member 1	Homo sapiens	141-144
34163009-7	2021	Our datasets suggest that suppression of cholesterol biosynthesis may facilitate water retention in the kidney by indirectly facilitating the AQP2-mediated water reabsorption.	Water	81-86	aquaporin-2	Camelus dromedarius	142-146
30063889-5	2018	FT-IR revealed that the salt, in combination with the hydrophilic silica, trapped water that provided a repulsive surface to the hydrophobic ELP and forced the ELP to continuously minimize its surface area until the water evaporated.	Water	82-87	nuclear receptor subfamily 5 group A member 1	Homo sapiens	160-163
28934999-9	2018	The observed results revealed that the concentration of Cd+2 in groundwater was higher than the World Health Organization recommended value of 3 microg/L for drinking water.	Water	70-75	CD2 molecule	Homo sapiens	56-60
34163009-7	2021	Our datasets suggest that suppression of cholesterol biosynthesis may facilitate water retention in the kidney by indirectly facilitating the AQP2-mediated water reabsorption.	Water	156-161	aquaporin-2	Camelus dromedarius	142-146
34155009-1	2021	A 14-year-old girl, a rear seat passenger on a jet-ski not wearing suitable protective gear, was "jumping" waves at a low velocity when she was ejected backwards off the vehicle, suffering a complex and unusual hydrostatic perineal injury as a result of the high-pressure water stream propelling the jet-ski.	Water	272-277	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	0-4
29407643-4	2018	Our results reveal that choice of hNoV purification methodology prior to seeding the viruses in an experimental water matrix influences disinfection outcomes in treatment studies.	Water	112-117	cellular communication network factor 3	Homo sapiens	34-38
30132034-7	2018	In the long term, the resetting of energy/salt/water physiology following SGLT2 inhibition has an impact, not only on adiposity, renal function and blood pressure control, but also on the health and survival of patients with type 2 diabetes.	Water	47-52	solute carrier family 5 member 2	Homo sapiens	74-79
29624058-0	2018	Slowing the Starch Digestion by Structural Modification through Preparing Zein/Pectin Particle Stabilized Water-in-Water Emulsion.	Water	106-111	zein	Zea mays	74-78
34204260-2	2021	It has been shown that in these cases it is possible to obtain concrete containing 30% by volume with density of approximately 1900 kg/m3 and the compressive strength > 70 MPa, with a very low water absorption value (3.3%), equal to the water absorption value of RPC without lightweight aggregate (3.3%).	Water	237-242	RNA 3'-terminal phosphate cyclase	Homo sapiens	263-266
29624058-0	2018	Slowing the Starch Digestion by Structural Modification through Preparing Zein/Pectin Particle Stabilized Water-in-Water Emulsion.	Water	115-120	zein	Zea mays	74-78
29718707-4	2018	Water deprivation enhanced Arg-II expression, AQP2 levels, and membrane association in collecting ducts.	Water	0-5	aquaporin 2	Mus musculus	46-50
29718707-5	2018	Effects of water deprivation on AQP2 were stronger in Arg-II-/- mice than in WT mice.	Water	11-16	aquaporin 2	Mus musculus	32-36
34204568-7	2021	Actinobacteria grow in diverse environments, and lcp gene containing strains have been detected from various sources including soil, water, human, animal, and plant samples.	Water	133-138	kelch domain containing 2	Homo sapiens	49-52
29498161-2	2018	Co4 N, with its beneficial metallic characteristics, has been proved to be highly active for the oxidation of water, while it is notoriously poor for catalyzing the hydrogen evolution reaction (HER), because of its unfavorable d-band energy level.	Water	110-115	complement C4A (Rodgers blood group)	Homo sapiens	0-3
30487657-5	2018	Positive feedbacks from sea ice growth-induced albedo increases and decreased downwelling longwave radiation due to reduced water vapor content amplify the cooling relative to the shipping-free Arctic.	Water	124-129	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	24-27
34081434-3	2021	This type of device can produce an open-circuit voltage (UOC) of up to 4 V and a short-circuit current (ISC) of ~18 muA with only an 8 muL water droplet applied.	Water	139-144	tripartite motif containing 37	Homo sapiens	135-138
30232405-2	2018	Sensor H4L was found to have excellent selectivity for B4O72- over many other anions (Br-, CI-, CN-, CO32-, HCO3-, H2PO4-, HSO4-, NO3-, OAc-, S2O3-, SCN-, SO42-, Hcy (homocysteine) and H2O2), and it exhibited an approximately 150-fold enhancement of the fluorescence response to B4O72- in Tris-HCl buffer (DMF/H2O = 9:1, v/v, pH = 7) solutions.	Water	185-188	H4 clustered histone 7	Homo sapiens	7-10
30232405-4	2018	The detection limit of sensor H4L towards B4O72- was 8.61 x 10-7 M. The test strips could conveniently, efficiently and simply detect B4O72- ions in Tris-HCl buffer (DMF/H2O = 9:1, v/v, pH = 7) solutions.	Water	170-173	H4 clustered histone 7	Homo sapiens	30-33
29732273-0	2018	Stability of CoP x Electrocatalysts in Continuous and Interrupted Acidic Electrolysis of Water.	Water	89-94	caspase recruitment domain family member 16	Homo sapiens	13-16
29732273-2	2018	Yet, their stability is inferior to platinum and compromises the large-scale applicability of CoP x in water electrolyzers.	Water	103-108	caspase recruitment domain family member 16	Homo sapiens	94-97
34081434-6	2021	An LED with a working voltage of 3-3.2 V can operate for a short time with the power from a single CAC device exposed to one 8 muL water droplet.	Water	131-136	tripartite motif containing 37	Homo sapiens	127-130
34081434-7	2021	Furthermore, a CAC generator adsorbing as little as 2 muL water droplets every 3 min can also give a UOC of 3.63 V. We show that CAC devices provide a robust electrical output over more than 200 wet-dry cycles without any deterioration in performance.	Water	58-63	tripartite motif containing 37	Homo sapiens	54-57
29681857-7	2018	Results: The synthesized GILZ-p, which was water-soluble, entered cells and bound with NF-kappaB p65, inhibiting p65 nuclear translocation.	Water	43-48	TSC22 domain family, member 3	Rattus norvegicus	25-29
34127363-2	2022	This study was designed to evaluate the performance of 3.0 T non-contrast-enhanced Dixon water-fat separation CS whole-heart CMRA sequence in vitro and in vivo.	Water	89-94	citrate synthase	Homo sapiens	110-112
29675407-7	2018	AQP7, an aquaglyceroporin permeated by water and glycerol, is expressed in pancreatic beta-cells and murine studies have confirmed its participation in insulin secretion, triacylglycerol synthesis and proliferation of these endocrine cells.	Water	39-44	aquaporin 7	Mus musculus	0-4
28983824-5	2018	A significant contribution to this difference is the efficient export of surface water acidification to the North Sea on a timescale of 15-20 years.	Water	81-86	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	114-117
30217234-7	2018	RESULTS: Ion channels exhibited cut-off effects associated with hydrocarbon molar water solubility in the following order of decreasing solubility: Nav1.2   Nav1.4   TRESK   TREK-1 &gt; GABAA &gt;&gt; glycine.	Water	82-87	sodium voltage-gated channel alpha subunit 4	Homo sapiens	157-163
34127363-8	2022	The sensitivity, specificity, positive predictive values, negative predictive values, and accuracy of 3.0 T non-contrast-enhanced Dixon water-fat separation CS whole-heart CMRA according to a patient-based analysis were 96.4%, 66.7%, 73.0%, 95.2% and 81.0%, respectively.	Water	136-141	citrate synthase	Homo sapiens	157-159
34127363-9	2022	The area under the receiver-operator characteristic (ROC) curve (AUC) of 3.0 T non-contrast-enhanced Dixon water-fat separation CS whole-heart CMRA for detecting significant coronary artery stenosis is 0.908, 0.895, and 0.904 in patient-, vessel-, and segment-based analyses respectively.	Water	107-112	citrate synthase	Homo sapiens	128-130
29455395-1	2018	Aquaporin 5 (AQP5) is a water channel protein that is over-expressed in many tumors.	Water	24-29	aquaporin 5	Homo sapiens	0-11
34108553-2	2021	In the present study, we identified that the human fragile histidine triad (FHIT) protein is a direct binding protein of sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of Tanshinone IIA (TSA), with a Kd value of 268.4 +- 42.59 nM.	Water	162-167	fragile histidine triad diadenosine triphosphatase	Homo sapiens	76-80
29455395-1	2018	Aquaporin 5 (AQP5) is a water channel protein that is over-expressed in many tumors.	Water	24-29	aquaporin 5	Homo sapiens	13-17
29421402-8	2018	Interactions between SNPs and water As on skin lesion risk were suggestive for three variants: the G allele of MTRR rs1801394 and T allele of FOLR1 rs1540087 were associated with lower odds of skin lesions with lower As (&lt;=50 mug/L), and the T allele of TYMS rs1001761 was associated with higher odds of skin lesions with higher As.	Water	30-35	folate receptor alpha	Homo sapiens	142-147
29421402-8	2018	Interactions between SNPs and water As on skin lesion risk were suggestive for three variants: the G allele of MTRR rs1801394 and T allele of FOLR1 rs1540087 were associated with lower odds of skin lesions with lower As (&lt;=50 mug/L), and the T allele of TYMS rs1001761 was associated with higher odds of skin lesions with higher As.	Water	30-35	thymidylate synthetase	Homo sapiens	257-261
30275765-0	2018	Acid-electrolyzed functional water induces extracellular matrix metalloproteinase inducer, a possible novel alarmin, secretion from oral squamous cell carcinoma cell lines.	Water	29-34	basigin (Ok blood group)	Homo sapiens	43-89
30275765-1	2018	Extracellular matrix metalloproteinase inducer (EMMPRIN) secretion was induced in the oral squamous cell carcinoma cell line HSC3 cell by acid-electrolyzed functional water (FW) stimulation.	Water	167-172	basigin (Ok blood group)	Homo sapiens	0-46
34199389-10	2021	Furthermore, CS/PLA-GO composites showed excellent water-barrier properties.	Water	51-56	citrate synthase	Homo sapiens	13-15
30275765-1	2018	Extracellular matrix metalloproteinase inducer (EMMPRIN) secretion was induced in the oral squamous cell carcinoma cell line HSC3 cell by acid-electrolyzed functional water (FW) stimulation.	Water	167-172	basigin (Ok blood group)	Homo sapiens	48-55
29499206-5	2018	S100B KO mice were resistant to STZ induced-diabetes with lower urine volume, food and water intake compared to WT mice.	Water	87-92	S100 protein, beta polypeptide, neural	Mus musculus	0-5
34365448-6	2021	In this work, we examine the method of bromelain"s chemical modification with a water-soluble, biocompatible and biodegradable natural polysaccharide - dextran, oxidized to dextran aldehyde.	Water	80-85	TATA-binding protein-associated factor 2N-like	Ananas comosus	39-48
29291402-9	2018	Knockdown of CHOP decreased the brain water content, reduced Evans blue extravasation, and improved neurological functions.	Water	38-43	DNA-damage inducible transcript 3	Rattus norvegicus	13-17
30136587-0	2018	N, N"-Dioxide/Gd(OTf)3 Complex-Promoted Asymmetric Aldol Reaction of Silyl Ketene Imines with Isatins: Water Plays an Important Role.	Water	103-108	POU class 5 homeobox 1	Homo sapiens	17-22
34135917-3	2021	Since construction costs and water loss by transpiration play a role in leaf longevity, we speculated that floral structures may affect the maintenance and loss of water in flowers and, therefore, FL.	Water	164-169	fms related receptor tyrosine kinase 3 ligand	Homo sapiens	197-199
30181477-1	2018	Colorimetric biosensors of cholinesterase inhibitors are ideal for fast, reliable, and very simple detection of agents in air, in water, and on surfaces.	Water	130-135	butyrylcholinesterase	Homo sapiens	27-41
34135917-10	2021	The ability to retain water in the flowers was associated with FL.	Water	22-27	fms related receptor tyrosine kinase 3 ligand	Homo sapiens	63-65
34071911-7	2021	The 70% EtOH, CH2Cl2-soluble fraction, and water-soluble fraction inhibited the production of prostaglandin E2, interleukin-6, and tumor necrosis factor-alpha, as well as markedly blocking LPS-induced expression of inducible NO synthase and cyclooxygenase-2 via inactivation of the nuclear factor-kappa B pathway.	Water	43-48	prostaglandin-endoperoxide synthase 2	Mus musculus	241-257
34163836-1	2021	In this report it is shown that nitroacetic acid 1 (O2NCH2CO2H) can be conveniently used to control the pH of a water solution over time.	Water	112-117	phenylalanine hydroxylase	Homo sapiens	104-106
34153284-3	2021	It has been proposed that Ces1d/CES1 might also catalyze cholesteryl ester (CE) hydrolysis in the liver and be responsible for the hydrolysis of high-density lipoprotein (HDL)-derived CE, thus contributing to the final step in the reverse cholesterol transport (RCT) pathway, where cholesterol is secreted from the liver into bile and feces, either directly or after conversion to water-soluble bile salts.	Water	381-386	carboxylesterase 1	Homo sapiens	32-36
34989203-11	2021	Drinking 1% H<sub>2</sub>O<sub>2</sub> water significantly (p<u><</u>0.01)decreased the estrous cycle time, body, ovary and uterus weights, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone and estrogen (E2) levels, uterine and ovarian superoxide dismutase (SOD) activity and reduced glutathione (GSH) level while caused a substantial increase (p<u><</u>0.01) in uterine and ovarian malondialdehyde (MDA) level, DNA fragmentation percent, caspase-3 (Casp-3), 8-hydroxydeoxyguanosine (8-OHdG), tumour necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2) levels as well as cyclooxygenase-2 (COX-2) activity.	Water	39-44	caspase 3	Rattus norvegicus	470-479
34989203-11	2021	Drinking 1% H<sub>2</sub>O<sub>2</sub> water significantly (p<u><</u>0.01)decreased the estrous cycle time, body, ovary and uterus weights, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone and estrogen (E2) levels, uterine and ovarian superoxide dismutase (SOD) activity and reduced glutathione (GSH) level while caused a substantial increase (p<u><</u>0.01) in uterine and ovarian malondialdehyde (MDA) level, DNA fragmentation percent, caspase-3 (Casp-3), 8-hydroxydeoxyguanosine (8-OHdG), tumour necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2) levels as well as cyclooxygenase-2 (COX-2) activity.	Water	39-44	caspase 3	Rattus norvegicus	481-487
35500463-2	2022	The sensor was composed of flexible reference electrode, pH response electrode and K+ selective electrode, which were prepared through printing beta-CD functionalized graphene (beta-CD/RGO) water suspension on conductive PET substrate with microelectronic printer.	Water	190-195	phenylalanine hydroxylase	Homo sapiens	57-59
35378434-8	2022	However, the total interaction energy of glycerol with DNA is lower than that of total water-DNA interaction energy indicating that it might be easier for an approaching DNA-binding protein to displace glycerol than water and thus contributing positively to protein-DNA binding.	Water	87-92	zinc finger protein 763	Homo sapiens	170-189
35378434-8	2022	However, the total interaction energy of glycerol with DNA is lower than that of total water-DNA interaction energy indicating that it might be easier for an approaching DNA-binding protein to displace glycerol than water and thus contributing positively to protein-DNA binding.	Water	216-221	zinc finger protein 763	Homo sapiens	170-189
35466690-2	2022	Despite the remarkable benefits, the molecular mechanisms mediating the effects of SGLT2 inhibitors on water and electrolyte balance are incompletely understood.	Water	103-108	solute carrier family 5 member 2	Rattus norvegicus	83-88
35430393-0	2022	Novel potential NOX2 inhibitors, Dudleya brittonii water extract and polygalatenoside A inhibit intracellular ROS generation and growth of melanoma.	Water	51-56	cytochrome b-245, beta polypeptide	Mus musculus	16-20
34997582-10	2022	Consequently, mice with hippocampal 5-HT3R disruption exhibited impaired spatial memory in Morris water maze tasks.	Water	98-103	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	36-42
35089520-3	2022	In this research, an inexact two-stage fractional programming model was developed for the allocation of water and land resources, which is integrated interval-parameters (IPP), two-stage stochastic programming (TSP), fractional programming (FP).	Water	104-109	intracisternal A particle-promoted polypeptide	Homo sapiens	171-174
35608627-0	2022	Ratio of Hydrophobic-Hydrophilic and Positive-Negative Residues at Lipid-Water-Interface Influences Surface Expression and Channel Gating of TRPV1.	Water	73-78	transient receptor potential cation channel subfamily V member 1	Homo sapiens	141-146
35608627-1	2022	During evolution, TRPV1 has lost, retained or selected certain residues at Lipid-Water-Interface (LWI) and formed specific patterns there.	Water	81-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-23
35608627-8	2022	The segment of TRPV1 that is present at the inner lipid-water-interface (LWI) has a specific pattern of amino acid combinations.	Water	56-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
35171433-10	2022	Inhibition of IRE1alpha, with STF083010, remarkably reduced brain water content, improved neurological function, decreased hematoma volume, upregulated the expression of miR-125b-2-3p, decreased the number of mast cells, and downregulated the protein expression of Lyn kinase, XBP1s (spliced X-box binding protein-1), tryptase, IL-17A and TNF-alpha.	Water	66-71	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	14-23
35361560-12	2022	CONCLUSION: A 24-h water-only intermittent fasting regimen increased galectin-3.	Water	19-24	galectin 3	Homo sapiens	69-79
35582984-1	2022	We characterized the anti-E2, syn-E2, inv-SN2, and ret-SN2 reaction channels for the reaction of microsolvated HO-(H2O)n anions with CH3CH2X (X = Cl, Br, I), using the CCSD(T)/PP/t//MP2/ECP/d level method, to understand how a solvent influences the competing E2 and SN2 reactions.	Water	115-118	inversin	Homo sapiens	38-41
35124036-8	2022	Under RCP 4.5, the average projected increase in water demand in 2030 will be about 7.32% for all SSP scenarios narratives, and 10.82% by mid-century.	Water	49-54	CGRP receptor component	Homo sapiens	6-9
35293679-5	2022	MTF-1 has been explored as efficient catalyst for electrochemical and photoelectrochemical hydrogen evolution reaction (HER) via water splitting reactions.	Water	129-134	metal regulatory transcription factor 1	Homo sapiens	0-5
35615306-6	2022	After thermotherapy (half-body immersion in a hot water bath at 42 +- 0.5  C, circulating orexin level increased more (p < 0.05) in the CAFF group than in the CON group.	Water	50-55	hypocretin neuropeptide precursor	Homo sapiens	90-96
35593110-9	2022	Supplementing drinking water with polysialic acid precursors (ManNAc) in drinking water could partially rescue submandibular gland regeneration in sialin knockdown rats.	Water	23-28	solute carrier family 17 member 5	Rattus norvegicus	147-153
35579458-5	2022	We found the sinking of Trichodesmium into deep water was far more efficient than that of Prochlorococcus, suggesting Trichodesmium blooms might be an essential carbon and nitrogen source for the maintenance of the BoB OMZ.	Water	48-53	G protein-coupled receptor 15	Homo sapiens	215-218
29596360-0	2018	A Reversible Bis(Salamo)-Based Fluorescence Sensor for Selective Detection of Cd2+ in Water-Containing Systems and Food Samples.	Water	86-91	CD2 molecule	Homo sapiens	78-81
35615428-14	2022	However, increase in CD68 protein was found in groups treated with CuO NPs and CuSO4 0.5 (H2O) compared with the control group.	Water	90-93	CD68 antigen	Mus musculus	21-25
35560241-4	2022	The initial viscosity of thickened water samples (pH 5.3 and 7.4) was reduced by 80% after only 5 s of in vitro oral digestion.	Water	35-40	phenylalanine hydroxylase	Homo sapiens	50-52
29261513-0	2018	High-content hydrogen water-induced downregulation of miR-136 alleviates non-alcoholic fatty liver disease by regulating Nrf2 via targeting MEG3.	Water	22-27	microRNA 136	Mus musculus	54-61
29261513-0	2018	High-content hydrogen water-induced downregulation of miR-136 alleviates non-alcoholic fatty liver disease by regulating Nrf2 via targeting MEG3.	Water	22-27	maternally expressed 3	Mus musculus	140-144
29751247-10	2018	Tubewell water samples were free from T-pesticide threat but exceeded the EC limit (0.10 ng mL-1) for single pesticide in case of chlorpyrifos only.	Water	9-14	L1 cell adhesion molecule	Mus musculus	92-96
35486525-2	2022	The RO experiments with NaCl aqueous solution (2000 ppm) indicated that the introduction of hydroxyethylurea groups markedly improved the permeability of water (1.86 x 10-12 m3/m2sPa) to approximately 19 times higher than that of a membrane prepared via the BTESPA homopolymerization, with NaCl rejection remaining nearly unchanged (96%).	Water	154-159	surfactant protein A1	Homo sapiens	179-182
30139551-4	2018	We observed that water loss rate in the cop1-4 and lip1 detached leaves was significantly much faster than wild-type, resulting from failing to reduce the stomatal aperture by the mutants.	Water	17-22	Ras-related small GTP-binding family protein	Arabidopsis thaliana	51-55
29566083-5	2018	AQP9 is permeable to a broad spectrum of substrates including purines, pyrimidines, and lactate, in addition to water and glycerol.	Water	112-117	aquaporin 9	Mus musculus	0-4
35524983-6	2022	A fire-retardant composite gel electrolyte is developed to further strengthen the intrinsic safe redox between Li2 S cathode and Si anode, which secures remarkable safety against extreme abuse of overheating, short circuits and mechanical damage in the air/water or even on fire.	Water	257-262	ATP binding cassette subfamily A member 12	Homo sapiens	111-114
29561787-9	2018	On the contrary, HCN will be generated instead of NH3 when H2O attacks the C3 position of pyrrole with its hydroxyl group.	Water	59-62	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	17-20
29710586-12	2018	The overall results demonstrated that both N-AC and S-AC could be the promising efficient candidates for removing Cd2+ and Pb2+ from contaminated water.	Water	146-151	CD2 molecule	Homo sapiens	114-117
29741184-2	2018	This complex undergoes photorelease of the Cbz-Leu-NHCH2CN ligand, a known cathepsin K inhibitor, with a quantum yield, Phi450, of 0.0012(4) in water (lambdairr = 450 nm).	Water	144-149	cathepsin K	Homo sapiens	75-86
29507247-6	2018	29beta-NAc binds tightly to FmlH by engaging the residues Y46 through edge-to-face pi-stacking with its A-phenyl ring, R142 in a salt-bridge interaction with its carboxylate group, and K132 through water-mediated hydrogen bonding with its N-acetyl group.	Water	198-203	basic transcription factor 3	Homo sapiens	2-10
35601312-8	2022	ABC powder has the best explosion suppression effect; the inhibition of a secondary explosion of pulverized coal is 4.17 times that of rock powder, the inhibition of flame is 4.28 times that of rock powder, and the inhibition of shock wave is 2.24 times that of water.	Water	262-267	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	0-3
29520064-0	2018	Sedimentary noise and sea levels linked to land-ocean water exchange and obliquity forcing.	Water	54-59	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	22-25
29520064-5	2018	This supports the hypothesis that long-period (1-2 myr) astronomically forced water mass exchange between land and ocean reservoirs is a missing link for reconciling geological records and models for sea-level change during non-glacial periods.	Water	78-83	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	200-203
35166891-4	2022	In contrast, gene encoding claudin-2 that mediates increase permeability to water and ions was upregulated in the small intestine.	Water	76-81	claudin 2	Mus musculus	27-36
29607267-10	2018	Catalytic hydrodeoxygenation of BTO toward cyclohexanone in water was achieved in up to 45% yield using 5 wt % Pd on Al2O3 combined with AlCl3 or Al(OTf)3 as catalysts.	Water	60-65	POU class 5 homeobox 1	Homo sapiens	149-154
30150508-0	2018	Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/beta-Catenin Signaling in Colon Cancer Cells.	Water	52-57	catenin beta 1	Homo sapiens	84-96
35131386-10	2022	Taken together, we conclude that the PVH is a site of action for GLP-1 receptor activation in the inhibition of water intake, but suspect that endogenous GLP-1 in NTS-to-PVH projections may be counterbalanced by a parallel pathway that either activates or maintains already activated water intake.	Water	112-117	glucagon like peptide 1 receptor	Homo sapiens	65-79
30063827-2	2018	However, besides glycine, a plethora of other compounds are also generated when CH2O and HCN react in the presence of ammonia and water.	Water	130-135	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	89-92
29498700-4	2018	In this study, we analyzed the surface water of the La Junta creek, in the southern part of the San Antonio-El Triunfo mining district.	Water	39-44	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	96-99
35452564-8	2022	BNP has a protective effect on water and electrolytes to prevent hypernatremia.	Water	31-36	natriuretic peptide B	Homo sapiens	0-3
29380891-2	2018	Stable dispersions of hydrophilic hGO sheets in water ( 100 mg mL-1 ) can be readily achieved.	Water	48-53	L1 cell adhesion molecule	Mus musculus	63-67
30138334-0	2018	The thirsty fly: Ion transport peptide (ITP) is a novel endocrine regulator of water homeostasis in Drosophila.	Water	79-84	Ion transport peptide	Drosophila melanogaster	17-38
30138334-0	2018	The thirsty fly: Ion transport peptide (ITP) is a novel endocrine regulator of water homeostasis in Drosophila.	Water	79-84	Ion transport peptide	Drosophila melanogaster	40-43
30138334-9	2018	Altogether, our work identifies ITP as an important endocrine regulator of thirst and excretion, which integrates water homeostasis with feeding of Drosophila.	Water	114-119	Ion transport peptide	Drosophila melanogaster	32-35
35487592-2	2022	In recent years, it has been indicated that the MR expressed in retinal Muller cells plays an important role in regulating the potassium and water balance in the retina.	Water	141-146	nuclear receptor subfamily 3 group C member 2	Homo sapiens	48-50
30135605-6	2018	We characterize interannual interior ocean variability in the Mediterranean Sea in the early 20th century contained in tidal measurements in the Strait of Messina, and demonstrate the general applicability of our method, paving the way to a new approach to analyze historical oceanographic records: Regions where different water masses are known to collide can thus act as magnifying glasses for basin-scale interior ocean variability, hence providing "liquid archives" for climatology.	Water	323-328	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
29153716-4	2018	For comparison, porous flower-like, belt-like and net-like CdS samples with different preferred degrees of (0 0 2) facet were controllably synthesized by the addition of H2O in different proportions.	Water	170-173	CDP-diacylglycerol synthase 1	Homo sapiens	59-62
30027186-4	2018	Ir1 was found to be weakly emissive in CH3CN-H2O, which is probably due to the effect of hydrogen bonding between the orotate ligands and H2O molecules.	Water	45-48	nischarin	Homo sapiens	0-3
35501613-2	2022	Simultaneous detection of nitrates, phosphates, and pH is of importance in soil and water analysis, agriculture, and food quality assessment.	Water	84-89	phenylalanine hydroxylase	Homo sapiens	52-54
30027186-4	2018	Ir1 was found to be weakly emissive in CH3CN-H2O, which is probably due to the effect of hydrogen bonding between the orotate ligands and H2O molecules.	Water	138-141	nischarin	Homo sapiens	0-3
29413116-11	2018	In the presence of silicon-rich water, LPS-stimulated and unstimulated PMs from aluminum-exposed rats produced significantly more IL-10.	Water	32-37	interleukin 10	Rattus norvegicus	130-135
29413116-13	2018	The presence of high levels of the natural aluminum antagonist silicon in the drinking water restored IL-10 and TNF-alpha PM secretion, preventing prolonged inflammation.	Water	87-92	interleukin 10	Rattus norvegicus	102-107
35413181-8	2022	Subsequent hybridization of nanostructured MoS2 with LaCoO3 provides a bifunctional catalytic system with an increased BET surface area of 33.4 m2/g for an overall improvement in water splitting with a low onset potential (HER: 242 mV and OER: 1.6 V @10 mA cm-2) and Tafel slope (HER: 78 mV dec-1; OER: 62.5 mV dec-1).	Water	179-184	delta/notch like EGF repeat containing	Homo sapiens	119-122
30356966-0	2018	Fe-CoP Electrocatalyst Derived from a Bimetallic Prussian Blue Analogue for Large-Current-Density Oxygen Evolution and Overall Water Splitting.	Water	127-132	caspase recruitment domain family member 16	Homo sapiens	3-6
29475323-2	2018	One can find that the OCLs will eventually evolve into Gaussian shape with the periodicity reciprocity gradually breaking down when propagating through the anisotropic ocean water, and that the trend of evolving into Gaussian can be accelerated for increasing the ratio of temperature and salinity contributions to the refractive index spectrum omega, the lattice constant a and the rate of dissipation of mean square temperature chiT or decreasing the anisotropic factor xi and the rate of dissipation of turbulent kinetic energy per unit mass of fluid epsilon.	Water	174-179	chitinase 1	Homo sapiens	430-434
35417126-2	2022	Herein, the exquisite combination of (Y2(CO2)7(H2O)2) cluster (abbreviated as {Y2}) and multifunctional linker of 2,4,6-tri(2,4-dicarboxyphenyl)pyridine (H6TDP) led to a nanoporous framework of {(Y2(TDP)(H2O)2) 5H2O 4DMF}n (NUC-53, NUC = North University of China), which is a rarely reported binuclear three-dimensional (3D) framework with hierarchical tetragonal-microporous (0.78 nm) and octagonal-nanoporous (1.75 nm) channels.	Water	47-50	nucleobindin 1	Homo sapiens	232-235
30093649-5	2018	EGF treatment improved dermatitis score, ear thickness, epidermal hyperplasia, serum total immunoglobulin E level, and transepidermal water loss in NC/Nga mice with DNCB-induced AD.	Water	134-139	epidermal growth factor	Mus musculus	0-3
29753257-5	2018	Also, our results demonstrate that the hydration level of CPe bilayers is substantially lower than PC bilayers and the averaged orientation of water dipoles in the region of CPe headgroups is effectively inverted compared to PC lipids.	Water	143-148	carboxypeptidase E	Homo sapiens	174-177
35417126-2	2022	Herein, the exquisite combination of (Y2(CO2)7(H2O)2) cluster (abbreviated as {Y2}) and multifunctional linker of 2,4,6-tri(2,4-dicarboxyphenyl)pyridine (H6TDP) led to a nanoporous framework of {(Y2(TDP)(H2O)2) 5H2O 4DMF}n (NUC-53, NUC = North University of China), which is a rarely reported binuclear three-dimensional (3D) framework with hierarchical tetragonal-microporous (0.78 nm) and octagonal-nanoporous (1.75 nm) channels.	Water	204-207	nucleobindin 1	Homo sapiens	232-235
35470441-8	2022	Water-exposed females drinking ethanol showed more social investigation as well as significantly higher hypothalamic OXTR, AVP, and AVPR1b gene expression than their counterparts ingesting supersac and AIE females drinking ethanol.	Water	0-5	arginine vasopressin receptor 1B	Rattus norvegicus	132-138
35460128-0	2022	Boosting Electrochemical Styrene Transformation via Tandem Water Oxidation over Single-Atom Cr1 /CoSe2 Catalyst.	Water	59-64	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	92-95
29806965-3	2018	In our present study, a water-soluble polysaccharide, named THP with molecular weight of 93 307 Da, was isolated from T. hemsleyanum by DEAE-52 ion-exchange and Sephadex G-100 chromatography.	Water	24-29	uromodulin	Mus musculus	60-63
35349262-0	2022	Incorporating Oxygen Atoms in a SnS2 Atomic Layer to Simultaneously Stabilize Atomic Hydrogen and Accelerate the Generation of Hydroxyl Radicals for Water Decontamination.	Water	149-154	sodium voltage-gated channel alpha subunit 11	Homo sapiens	32-36
29772385-6	2018	Physical properties of the 6:18 mg/mL composite versus the 6:0 mg/mL collagen-only hydrogel characterized by swelling ratio, differential scanning calorimetry, and FTIR spectroscopy revealed that the addition of ELP reduced the residual water content in the composites and provided evidence of the presence of collagen-ELP interactions.	Water	237-242	nuclear receptor subfamily 5 group A member 1	Homo sapiens	212-215
29653685-0	2018	Corrigendum to "Hygroscopic behavior of water-soluble matter in marine aerosols over the East China Sea" [Sci.	Water	40-45	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	100-103
35435546-6	2022	The electrochemical synergistic degradation mechanism of Cu-Fe3O4 magnetic nanoparticles is complex, which can directly catalyze the degradation of HCN or form CNO- intermediates to further degrade into CO2, H2O, and NH3.	Water	208-211	biogenesis of lysosomal organelles complex 1 subunit 4	Homo sapiens	160-163
30065289-0	2018	Eco-friendly one-pot synthesis of Prussian blue-embedded magnetic hydrogel beads for the removal of cesium from water.	Water	112-117	ciliogenesis associated kinase 1	Homo sapiens	0-3
35428816-7	2022	Ion and water transporters might participate in the maintenance of pHi and mitochondria homeostasis in differentiated SPs, which may contribute, combined with integral barrier functions, to efficient water efflux.	Water	8-13	glucose-6-phosphate isomerase	Homo sapiens	67-70
30054494-3	2018	Here, we analyze water characteristics, observed during the last three decades in the abyssal Ionian Sea (Eastern Mediterranean), where two competing convective sources of bottom water exist.	Water	17-22	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	101-104
35428816-7	2022	Ion and water transporters might participate in the maintenance of pHi and mitochondria homeostasis in differentiated SPs, which may contribute, combined with integral barrier functions, to efficient water efflux.	Water	200-205	glucose-6-phosphate isomerase	Homo sapiens	67-70
35494240-4	2022	This framework considers the potential for terrestrial water input from the snowpack through decision tree classification of rain-on-snow and warm day melt events to aid in pattern recognition of prominent weather and antecedent snowpack conditions capable of producing snowpack runoff.	Water	55-60	activation induced cytidine deaminase	Homo sapiens	166-169
29555511-2	2018	Results indicate that thin adsorbed films of Mb in solution and as colloids, show atleast 3 steps in the interaction with the bilayers: i) An initial strain of a viscoelastic film ii) Entrained water that moves in and out of the adsorbed film and iii) The coupled load from the bulk liquid which increases the strain of the film.	Water	194-199	myoglobin	Homo sapiens	45-47
35457880-2	2022	Proper rehydration with appropriate amounts of water and electrolytes is essential to aid body fluid homeostasis.	Water	47-52	activation induced cytidine deaminase	Homo sapiens	86-89
30050530-4	2018	During onset and recovery of EAU, the level of sCD83 rises in the serum and aqueous humor, and CD83+ leukocytes infiltrate the inflamed eye.	Water	29-32	CD83 molecule	Homo sapiens	48-52
35196415-3	2022	Poly(2-(N-oxide-N,N-diethylamino)ethyl methacrylate) (OPDEA), a water-soluble polyzwitterion, is highly nonfouling to proteins and other biomacromolecules such as mucin but can weakly bind to phospholipids.	Water	64-69	LOC100508689	Homo sapiens	163-168
29916690-4	2018	In this work, we present that light-powered TiO2/Pt Janus micromotors have high efficiency for the "on-the-fly" photocatalytic degradation of 2,4-DNT and 2,4,6-TNT in pure water under UV irradiation.	Water	172-177	tnt	Drosophila melanogaster	160-163
35202915-6	2022	In vivo level, the two GLP-1 derivatives can significantly increase their glucose tolerance and prolong their half-life in ICR mice, and they were also superior to GLP-1 in controlling glucose homeostasis and suppression of food intake and water consumption in db/db mice.	Water	240-245	glucagon	Mus musculus	23-28
29685354-1	2018	gamma-Glutamyltransferase (GGT) catalyzes the transfer of the gamma-glutamyl moiety from a donor substrate such as glutathione to water (hydrolysis) or to an acceptor amino acid (transpeptidation) through the formation of a gamma-glutamyl enzyme intermediate.	Water	130-135	gamma-glutamyltransferase light chain family member 3	Homo sapiens	0-25
29685354-1	2018	gamma-Glutamyltransferase (GGT) catalyzes the transfer of the gamma-glutamyl moiety from a donor substrate such as glutathione to water (hydrolysis) or to an acceptor amino acid (transpeptidation) through the formation of a gamma-glutamyl enzyme intermediate.	Water	130-135	gamma-glutamyltransferase light chain family member 3	Homo sapiens	27-30
34995593-7	2022	The major drawback of porous concrete is the high pH (>8.5) of the effluent water, decalcification of the porous concrete and leaching of adsorbed pollutants.	Water	76-81	phenylalanine hydroxylase	Homo sapiens	50-52
29574343-6	2018	The PEG coating maintained the dispersity of LDH nanoparticles in water and saline with the feeding mass ratio of 1:1.	Water	66-71	progestagen associated endometrial protein	Homo sapiens	4-7
35544247-7	2022	RESULTS: We observed associations of syndecan 1 with extravascular lung water index (rho = 0.48, P =.04) at baseline and of heparan sulfate proteoglycan with extravascular lung water index (rho= -0.56, P = .03) and pulse pressure variation (rho = 0.53, P = .04) at 24 hours after fluid load test.	Water	72-77	syndecan 1	Homo sapiens	37-47
29806457-5	2018	This work suggests that CdS/WS2 has great potential as a low-cost and highly efficient photocatalyst for water splitting.	Water	105-110	CDP-diacylglycerol synthase 1	Homo sapiens	24-27
29793978-8	2018	Finally, we found that brain edema following traumatic brain injury was suppressed in TRPV4-deficient male mice in vivo Thus, our study proposes a novel mechanism: hyperthermia activates TRPV4 and induces brain edema after ischemia.SIGNIFICANCE STATEMENT Brain edema is characterized by an increase in net brain water content, which results in an increase in brain volume.	Water	312-317	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	86-91
29793978-8	2018	Finally, we found that brain edema following traumatic brain injury was suppressed in TRPV4-deficient male mice in vivo Thus, our study proposes a novel mechanism: hyperthermia activates TRPV4 and induces brain edema after ischemia.SIGNIFICANCE STATEMENT Brain edema is characterized by an increase in net brain water content, which results in an increase in brain volume.	Water	312-317	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	187-192
35104250-2	2022	We previously discovered that GRP170 regulates the degradation and assembly of the epithelial sodium channel (ENaC), which reabsorbs sodium in the distal nephron and thereby regulates salt-water homeostasis and blood pressure.	Water	189-194	hypoxia up-regulated 1	Mus musculus	30-36
35492279-1	2022	The title mol-ecular structure, namely, (mu3-acetato)(mu2-acetato)-bis-(mu3-1,3-bis-{(1-(2-oxidophen-yl)ethyl-idene)amino}-propan-2-olato)tetra-copper(II) monohydrate, (Cu4(C19H19N2O3)2(CH3CO2)2) H2O, corresponds to a non-symmetric tetra-nuclear copper complex.	Water	196-199	adaptor related protein complex 1 subunit mu 2	Homo sapiens	54-57
29597044-3	2018	The aim of this work was to study the absorption and transport mechanism across the intestinal barrier of new R-ALA stable and water soluble form, consisting in the lysine R-ALA salt, in presence and absence of specific inhibitors of Na+/multivitamin (SMVT) and monocarboxylic acids (MCT).	Water	127-132	RAS like proto-oncogene A	Rattus norvegicus	172-177
35066455-9	2022	A One Water approach will aid in protecting the health of the public from waterborne pathogens, regardless of where those pathogens entered the water system.	Water	6-11	activation induced cytidine deaminase	Homo sapiens	26-29
29867199-4	2018	The Na+/K+/2Cl- cotransporter (NKCC1) expressed in the luminal membrane of choroid plexus contributes approximately half of the CSF production, via its unusual outward transport direction and its unique ability to directly couple water transport to ion translocation.	Water	230-235	solute carrier family 12 member 2	Homo sapiens	31-36
34982299-0	2022	Deep Sea Water Alleviates Tau Phosphorylation and Cognitive Impairment via PI3K/Akt/GSK-3beta Pathway.	Water	9-14	glycogen synthase kinase 3 alpha	Homo sapiens	84-93
29478202-0	2018	Activation of AQP2 water channels without vasopressin: therapeutic strategies for congenital nephrogenic diabetes insipidus.	Water	19-24	aquaporin 2	Homo sapiens	14-18
29478202-4	2018	Vasopressin binds to the vasopressin type II receptor (V2R) in the renal collecting ducts and then activates AQP2 phosphorylation and trafficking to increase water reabsorption from urine.	Water	158-163	aquaporin 2	Homo sapiens	109-113
35061517-2	2022	Mucin is a thick gelatinous substance and-owing to its high water content-has imaging features that can be mistaken for those of simple fluid-containing neoplasms with multiple imaging modalities.	Water	60-65	LOC100508689	Homo sapiens	0-5
29601142-0	2018	Relocating cued goals induces population remapping in CA1 related to memory performance in a two-platform water task in rats.	Water	106-111	carbonic anhydrase 1	Rattus norvegicus	54-57
29020666-4	2018	Remarkably, HPH as a SERS marker supported on Au deposited monodispersed nanospheres monolayers (Au-MNM) of polystyrene offers an unprecedented selectivity and the best ever reported detection limit (LOD) of 60 attomolar (aM, 0.01 parts-per-quadrillion (ppq)) for Hg2+ in water.	Water	272-277	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	21-25
35020522-7	2022	Formulation of HBP (HBV surface protein)-encapsulated PLGA (HB-nanovaccine (HB-NV)) was conducted by using double emulsion solvent evaporation technique (water-oil-water), which resulted in 94% encapsulation efficiency and 24% protein loading capacity.	Water	154-159	heme binding protein 1	Homo sapiens	15-18
29328634-1	2018	The rich potential energy surface of the water undecamer (H2O)11 was explored with a basin hopping algorithm using a TIP4P potential and other methods followed by extensive ab initio MP2 minimizations and CCSD(T) corrections.	Water	41-46	tryptase pseudogene 1	Homo sapiens	183-186
29768224-3	2018	Enzymatic activity, stability, and reusability of PLGA-C1 NPs prepared using three different methods [oil in water (o/w), water in oil in water (w/o/w), and solid in oil in water (s/o/w)] were compared.	Water	109-114	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	50-61
29768224-3	2018	Enzymatic activity, stability, and reusability of PLGA-C1 NPs prepared using three different methods [oil in water (o/w), water in oil in water (w/o/w), and solid in oil in water (s/o/w)] were compared.	Water	122-127	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	50-61
29768224-3	2018	Enzymatic activity, stability, and reusability of PLGA-C1 NPs prepared using three different methods [oil in water (o/w), water in oil in water (w/o/w), and solid in oil in water (s/o/w)] were compared.	Water	122-127	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	50-61
29768224-3	2018	Enzymatic activity, stability, and reusability of PLGA-C1 NPs prepared using three different methods [oil in water (o/w), water in oil in water (w/o/w), and solid in oil in water (s/o/w)] were compared.	Water	122-127	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	50-61
35020522-7	2022	Formulation of HBP (HBV surface protein)-encapsulated PLGA (HB-nanovaccine (HB-NV)) was conducted by using double emulsion solvent evaporation technique (water-oil-water), which resulted in 94% encapsulation efficiency and 24% protein loading capacity.	Water	164-169	heme binding protein 1	Homo sapiens	15-18
29359939-6	2018	On the vibrational spectrum measured by IRAS, the strong hydrogen bonds between H2Cat-BMT-TTF and Im-SAM are characterized by the remarkably red-shifted OH stretching mode at 3140 cm-1, which is much lower than that for hydrogen-bonding water (typically ~3300 cm-1).	Water	237-242	ras homolog family member H	Homo sapiens	90-93
29666984-6	2018	CONCLUSION: The present cases harboring novel homozygous frameshift mutations in KCNJ10 expand the spectrum of brain abnormalities in EAST syndrome, including mild cerebellar atrophy and intramyelinic edema, resulting from abnormal function of the Kir4.1 inwardly rectifying potassium channel at the astrocyte endfeet, with disruption of water-ion homeostasis.	Water	338-343	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	81-87
35209821-4	2022	METHOD: This study was designed to explore the in vitro anticancer activity of the three fractions of lac dye, i.e., chloroform (C), methanol (M) and water (W) fractions and isolation of constituents from bioactive fraction.	Water	150-155	lactase	Homo sapiens	102-105
29666984-6	2018	CONCLUSION: The present cases harboring novel homozygous frameshift mutations in KCNJ10 expand the spectrum of brain abnormalities in EAST syndrome, including mild cerebellar atrophy and intramyelinic edema, resulting from abnormal function of the Kir4.1 inwardly rectifying potassium channel at the astrocyte endfeet, with disruption of water-ion homeostasis.	Water	338-343	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	248-254
29569314-5	2018	A particular cationic PDI gemini-type surfactant has been developed that forms nonfluorescent self-assembled particles in water ("off state"), which exerts a high fluorescence upon incorporation into lipophilic bilayers ("on state").	Water	122-127	peptidyl arginine deiminase 1	Homo sapiens	22-25
29687809-7	2018	The degradation of SMT in ambient water revealed that the AgTCM/UCN/PMS photocatalytic process can be efficaciously applied for the remediation of SMT contaminated natural waters, particularly sea water.	Water	34-39	urocortin	Homo sapiens	64-67
29783765-2	2018	Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), several analogues were identified with micromolar activity through targeted displacement of bound water molecules in the active site.	Water	263-268	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	102-154
29783765-2	2018	Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), several analogues were identified with micromolar activity through targeted displacement of bound water molecules in the active site.	Water	263-268	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	156-162
29807798-7	2018	Furthermore, pharmaceutical administration of a SMO antagonist LDE rescued Abeta-induced upregulation of SMO in astrocytes of mouse hippocampus, improved memory in Morris water maze (MWM), and reduced expression of astrocyte secreting pro-inflammatory factors IL-1beta, TNFalpha and the microglia marker IBA-1 in an APP/PS1 transgenic mouse model.	Water	171-176	smoothened, frizzled class receptor	Mus musculus	48-51
29807798-7	2018	Furthermore, pharmaceutical administration of a SMO antagonist LDE rescued Abeta-induced upregulation of SMO in astrocytes of mouse hippocampus, improved memory in Morris water maze (MWM), and reduced expression of astrocyte secreting pro-inflammatory factors IL-1beta, TNFalpha and the microglia marker IBA-1 in an APP/PS1 transgenic mouse model.	Water	171-176	amyloid beta (A4) precursor protein	Mus musculus	75-80
29694779-5	2018	In the n-body decomposition analysis, the SPC-3f(0) model predicts the best agreement with MP2/aug-cc-pVTZ calculations with the use of the low-dimensional (H2O)4-ring and (H2O)6-ring clusters.	Water	157-160	tryptase pseudogene 1	Homo sapiens	91-94
29694779-5	2018	In the n-body decomposition analysis, the SPC-3f(0) model predicts the best agreement with MP2/aug-cc-pVTZ calculations with the use of the low-dimensional (H2O)4-ring and (H2O)6-ring clusters.	Water	173-176	tryptase pseudogene 1	Homo sapiens	91-94
29664651-7	2018	The NCM functionalized with the GO-PEI additive demonstrated potential for high-performance pollutant removal in water and wastewater treatments.	Water	113-118	CWC22 spliceosome associated protein homolog	Homo sapiens	4-7
29453104-0	2018	Controlling shape anisotropy of hexagonal CdS for highly stable and efficient photocatalytic H2 evolution and photoelectrochemical water splitting.	Water	131-136	CDP-diacylglycerol synthase 1	Homo sapiens	42-45
29453104-2	2018	Hence, this work reports the shape anisotropy of hexagonal CdS possesses highly stable and efficient PC H2 evolution and PEC water splitting by simply mixed diethylenetriamine (DETA) and deionized water (DIW) solvothermal.	Water	125-130	CDP-diacylglycerol synthase 1	Homo sapiens	59-62
29453104-2	2018	Hence, this work reports the shape anisotropy of hexagonal CdS possesses highly stable and efficient PC H2 evolution and PEC water splitting by simply mixed diethylenetriamine (DETA) and deionized water (DIW) solvothermal.	Water	197-202	CDP-diacylglycerol synthase 1	Homo sapiens	59-62
29453104-10	2018	The possible mechanism of PC H2 evolution and PEC water spiltting are proposed for CdS-Nanorod.	Water	50-55	CDP-diacylglycerol synthase 1	Homo sapiens	83-86
29501197-4	2018	Under the optimal conditions with the addition of 2% (w/w) of NH3 H2O at 4 muL min-1, the instrument detection limits for bisphenol compounds were greatly lowered to 0.001-0.04 ng mL-1, which were 2-28.6 times lower than the result obtained without injecting NH3 H2O, except TBBPA (0.03 ng mL-1 in either case).	Water	66-69	L1 cell adhesion molecule	Mus musculus	180-184
29501197-4	2018	Under the optimal conditions with the addition of 2% (w/w) of NH3 H2O at 4 muL min-1, the instrument detection limits for bisphenol compounds were greatly lowered to 0.001-0.04 ng mL-1, which were 2-28.6 times lower than the result obtained without injecting NH3 H2O, except TBBPA (0.03 ng mL-1 in either case).	Water	66-69	L1 cell adhesion molecule	Mus musculus	290-294
29501197-4	2018	Under the optimal conditions with the addition of 2% (w/w) of NH3 H2O at 4 muL min-1, the instrument detection limits for bisphenol compounds were greatly lowered to 0.001-0.04 ng mL-1, which were 2-28.6 times lower than the result obtained without injecting NH3 H2O, except TBBPA (0.03 ng mL-1 in either case).	Water	263-266	L1 cell adhesion molecule	Mus musculus	180-184
29501197-4	2018	Under the optimal conditions with the addition of 2% (w/w) of NH3 H2O at 4 muL min-1, the instrument detection limits for bisphenol compounds were greatly lowered to 0.001-0.04 ng mL-1, which were 2-28.6 times lower than the result obtained without injecting NH3 H2O, except TBBPA (0.03 ng mL-1 in either case).	Water	263-266	L1 cell adhesion molecule	Mus musculus	290-294
30238024-5	2018	However, due to issues related to information protection, SABESP only provides data on six of the eight water-producing systems that supply the MASP with water.	Water	104-109	MBL associated serine protease 1	Homo sapiens	144-148
30238024-5	2018	However, due to issues related to information protection, SABESP only provides data on six of the eight water-producing systems that supply the MASP with water.	Water	154-159	MBL associated serine protease 1	Homo sapiens	144-148
29861828-5	2018	The results from the cell model showed that pretreatment of HUVEC with the water or alkaline extracts of the polysaccharides from the huskless barley cultivars QHH and NLGL decreased the levels of reactive oxygen species (ROS), monocyte chemotactic protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) but increased the level of superoxide dismutase (SOD) and maintained cell viability.	Water	75-80	vascular cell adhesion molecule 1	Mus musculus	272-305
29861828-5	2018	The results from the cell model showed that pretreatment of HUVEC with the water or alkaline extracts of the polysaccharides from the huskless barley cultivars QHH and NLGL decreased the levels of reactive oxygen species (ROS), monocyte chemotactic protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) but increased the level of superoxide dismutase (SOD) and maintained cell viability.	Water	75-80	vascular cell adhesion molecule 1	Mus musculus	307-313
29728624-1	2018	Broad scale assessments of impacts associated with sea level rise have mainly been undertaken using ocean water level data from tide gauges located in harbours and ports assuming that these can be applied directly in mapping inundation throughout estuaries.	Water	106-111	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	51-54
29676412-0	2018	Fabrication of hierarchical CoP nanosheet@microwire arrays via space-confined phosphidation toward high-efficiency water oxidation electrocatalysis under alkaline conditions.	Water	115-120	caspase recruitment domain family member 16	Homo sapiens	28-31
29676412-4	2018	When used as a 3D electrode for water oxidation electrocatalysis, such CoP NS@MW/NF needs an overpotential as low as 296 mV to drive a geometrical catalytic current density of 100 mA cm-2 in 1.0 M KOH, outperforming all reported Co phosphide catalysts in alkaline media.	Water	32-37	caspase recruitment domain family member 16	Homo sapiens	71-74
29671565-2	2018	Here, a water-/alcohol-soluble zwitterion perylene diimide zwitterion (PDI-z) consisted of sulfobetaine ion as a terminal substituent and PDI as a conjugated core was synthesized.	Water	8-13	peptidyl arginine deiminase 1	Homo sapiens	71-74
29671565-2	2018	Here, a water-/alcohol-soluble zwitterion perylene diimide zwitterion (PDI-z) consisted of sulfobetaine ion as a terminal substituent and PDI as a conjugated core was synthesized.	Water	8-13	peptidyl arginine deiminase 1	Homo sapiens	138-141
29150773-5	2018	The enzyme was highly stable at pH 3.0-8.0 with a half-life in water of 100 min at 65  C. The Egst presented good halotolerance, retaining 84.1 and 71.4% of the control activity in the presence of 0.5 and 2.0 mol L-1 NaCl, respectively.	Water	63-68	L1 cell adhesion molecule	Mus musculus	213-216
28240345-0	2018	Upregulated expression of La ribonucleoprotein domain family member 6 and collagen type I gene following water-filtered broad-spectrum near-infrared irradiation in a 3-dimensional human epidermal tissue culture model as revealed by microarray analysis.	Water	105-110	La ribonucleoprotein 6, translational regulator	Homo sapiens	26-69
28240345-7	2018	Quantitative real-time PCR revealed that, relative to control cells, the gene encoding La ribonucleoprotein domain family member 6 (LARP6), which regulates collagen expression, was significantly and dose-dependently upregulated (P &lt; 0.05) by water-filtered broad-spectrum near-infrared exposure.	Water	245-250	La ribonucleoprotein 6, translational regulator	Homo sapiens	87-130
28240345-7	2018	Quantitative real-time PCR revealed that, relative to control cells, the gene encoding La ribonucleoprotein domain family member 6 (LARP6), which regulates collagen expression, was significantly and dose-dependently upregulated (P &lt; 0.05) by water-filtered broad-spectrum near-infrared exposure.	Water	245-250	La ribonucleoprotein 6, translational regulator	Homo sapiens	132-137
29327391-3	2018	SLC4A11, in the CEC basolateral membrane, facilitates transmembrane movement of H2 O, NH3 , and H+ -equivalents.	Water	80-84	solute carrier family 4 member 11	Homo sapiens	0-7
29520938-11	2018	The standard deviations of the evaluated metrics for the S20 acquisition were 0.083(f30), 0.058(f40), 0.056(f50), 0.021(Water/poly-HU constancy), 0.029(uniformity) and 0.028(noise).	Water	120-125	ribosomal protein S20	Homo sapiens	57-60
29348563-8	2018	In accordance, anti-CXCR3 significantly enhanced SMG expression of tight junction protein claudin-1 and water channel protein aquaporin 5, two molecules that are crucial for normal salivary secretion and can be down-regulated by TNF-alpha.	Water	104-109	chemokine (C-X-C motif) receptor 3	Mus musculus	20-25
29046300-1	2018	Aquaporin-2 (AQP2) is a water channel protein expressed in principal cells (PCs) of the kidney collecting ducts (CDs) and plays a critical role in mediating water reabsorption and urine concentration.	Water	24-29	aquaporin 2	Mus musculus	0-11
29046300-1	2018	Aquaporin-2 (AQP2) is a water channel protein expressed in principal cells (PCs) of the kidney collecting ducts (CDs) and plays a critical role in mediating water reabsorption and urine concentration.	Water	24-29	aquaporin 2	Mus musculus	13-17
29225132-2	2018	The ginsenoside Rh4 (Rh4), a rare saponin obtained from Panax notoginseng, dissolves in water more readily than total saponins, making this compound easier to use in anti-cancer pharmaceutics.	Water	88-93	Rh blood group D antigen	Homo sapiens	16-19
29225132-2	2018	The ginsenoside Rh4 (Rh4), a rare saponin obtained from Panax notoginseng, dissolves in water more readily than total saponins, making this compound easier to use in anti-cancer pharmaceutics.	Water	88-93	Rh blood group D antigen	Homo sapiens	21-24
29254004-4	2018	MDC4 resulted in the lowest rehydration ratio among coated samples since, first, lower DE degrees of biopolymer complexes decreased moisture adsorption and solubility of maltodextrin and second, crystalline nanocellulose fibres increased tortuous and bended pathways in materials and reduced penetration possibilities of water molecules.	Water	321-326	phosphatidylinositol glycan anchor biosynthesis class N	Homo sapiens	0-4
29232732-1	2018	Urodilatin (UD) and uroguanylin (UGN) have been implicated in the regulation of salt and water homeostasis, particularly in the balance handling of salt intake.	Water	89-94	guanylate cyclase activator 2B	Rattus norvegicus	20-31
29232732-1	2018	Urodilatin (UD) and uroguanylin (UGN) have been implicated in the regulation of salt and water homeostasis, particularly in the balance handling of salt intake.	Water	89-94	guanylate cyclase activator 2B	Rattus norvegicus	33-36
29354815-0	2018	CoP nanoparticles anchored on N,P-dual-doped graphene-like carbon as a catalyst for water splitting in non-acidic media.	Water	84-89	caspase recruitment domain family member 16	Homo sapiens	0-3
29317616-0	2018	Freshwater lake to salt-water sea causing widespread hydrate dissociation in the Black Sea.	Water	5-10	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	30-33
29317616-0	2018	Freshwater lake to salt-water sea causing widespread hydrate dissociation in the Black Sea.	Water	5-10	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	87-90
29316651-7	2018	These results showed that when CPT-11 is administered, the expression level of AQP3 in the colon is reduced, resulting in delayed diarrhea by preventing water transport from the intestinal tract.	Water	153-158	aquaporin 3 (Gill blood group)	Rattus norvegicus	79-83
29111048-5	2018	Besides, porous RC/PEG exhibited good water absorbency, which the water absorbency ratio at equilibrium state was 83% higher than that of porous RC.	Water	38-43	progestagen associated endometrial protein	Homo sapiens	16-22
29908578-5	2018	We have reviewed the literature on balneotherapy in the treatment of skin diseases, as well as describing their use in three different treatment sites, each with unique climates and chemical properties of the mineral water used in balneotherapy-the Dead Sea in Israel and Jordan, the La Roche-Posay Thermal Center in France, and the Blue Lagoon in Iceland.	Water	217-222	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	254-257
29117938-3	2018	Receptor activation increases cAMP levels in principal cells, resulting in the incorporation of AQP2 into the membrane, finally increasing water reabsorption.	Water	139-144	aquaporin 2	Homo sapiens	96-100
29127633-8	2018	The particle-water partition coefficients (Koc) suggest that the partitioning of PAHs between the particulate and dissolved phases is driven by hydrophobicity and organic matter composition.	Water	13-18	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	43-46
29150978-7	2018	We subjected Grin1Rgsc174/+ mice to the water competition test using IntelliCage and observed that Grin1 influences competitive dominance.	Water	40-45	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	13-25
29150978-7	2018	We subjected Grin1Rgsc174/+ mice to the water competition test using IntelliCage and observed that Grin1 influences competitive dominance.	Water	40-45	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	13-18
28859549-11	2018	A battery of behavioral tests revealed that TBI in hTau mice resulted in compromised use of spatial search strategies to complete a water maze task, despite lack of motor or visual deficits.	Water	132-137	microtubule associated protein tau	Homo sapiens	51-55
28843412-1	2018	In the syndrome of inappropriate antidiuretic hormone secretion (SIADH), hyponatremia is limited by onset of vasopressin-escape caused by loss of the water channel aquaporin-2 in the renal collecting duct despite high circulating vasopressin.	Water	150-155	aquaporin 2	Rattus norvegicus	164-175
28843412-4	2018	The time-dependent mRNA abundance changes were mapped to gene sets associated with curated canonical signaling pathways and revealed evidence of perturbation of transforming growth factor beta signaling and epithelial-to-mesenchymal transition on Day 1 of water loading simultaneous with the initial fall in Aqp2 gene expression.	Water	256-261	aquaporin 2	Rattus norvegicus	308-312
29564982-11	2018	The molecular docking analysis of compound m45 with the N-terminal domain binding site of the HSP90 show hydroxyl group on phenyl ring is necessary to form hydrogen bonding with hydrophilic residues in binding site and a conserved water molecule.	Water	231-236	heat shock protein 90 alpha family class A member 1	Homo sapiens	94-99
28523565-6	2018	Increased brain water content can be attributed to increase in aquaporin-4 mRNA and protein expression in BDL rats.	Water	16-21	aquaporin 4	Rattus norvegicus	63-74
35209821-4	2022	METHOD: This study was designed to explore the in vitro anticancer activity of the three fractions of lac dye, i.e., chloroform (C), methanol (M) and water (W) fractions and isolation of constituents from bioactive fraction.	Water	157-158	lactase	Homo sapiens	102-105
35119870-3	2022	Herein, Zn foils coated by ZnF2-Ag nanoparticles (ZnF2-Ag@Zn) are used as a model to modulate the desolvation and nucleation processes by hybrid surfaces, where Ag has a strong affinity to Zn adatoms and ZnF2 shows an intense adsorption to H2O.	Water	240-243	zinc finger protein 2	Homo sapiens	50-54
35142326-6	2022	Water thermodynamics calculations reveal that the Ile71 pocket is occupied by high-energy water molecules, that are released upon the Ile71 binding, contributing favourably to the SETD3-betaA complex formation.	Water	0-5	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	180-185
29054630-7	2018	Water quality parameters differed among sampling points, being lower at the headwater sampling point (0m above sea level), and then progressively higher until the last downstream sampling point (2500m above sea level).	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	111-114
29054630-7	2018	Water quality parameters differed among sampling points, being lower at the headwater sampling point (0m above sea level), and then progressively higher until the last downstream sampling point (2500m above sea level).	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	207-210
35142326-6	2022	Water thermodynamics calculations reveal that the Ile71 pocket is occupied by high-energy water molecules, that are released upon the Ile71 binding, contributing favourably to the SETD3-betaA complex formation.	Water	90-95	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	180-185
29220763-9	2018	Although there was no change in the presence of the components themselves, their relative distributions varied during precipitation, with the C1/C2 ratio increasing with the proportion of soil pre-event water.	Water	203-208	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	142-147
35142765-3	2022	The method is applied to compute excitonic couplings between chlorophyll a (Chl a) pigments of the water-soluble chlorophyll-binding protein (WSCP).	Water	99-104	chordin like 1	Homo sapiens	76-79
35171678-5	2022	Spectral phasor analysis of ACDAN fluorescence reveals water dipolar relaxation and demonstrates that mutations in two zebrafish aquaporin 0s, Aqp0a and Aqp0b, alter water state and macromolecular crowding in living lenses.	Water	55-60	major intrinsic protein of lens fiber a	Danio rerio	143-148
29620114-2	2018	Herein, we report a highly water-soluble Eu(DPA)3@Lap nanohybrid material for the rapid and selective assay of PPi and ALP through a luminescence off-on recognition process.	Water	27-32	LAP	Homo sapiens	50-53
35171678-5	2022	Spectral phasor analysis of ACDAN fluorescence reveals water dipolar relaxation and demonstrates that mutations in two zebrafish aquaporin 0s, Aqp0a and Aqp0b, alter water state and macromolecular crowding in living lenses.	Water	166-171	major intrinsic protein of lens fiber a	Danio rerio	143-148
35171678-5	2022	Spectral phasor analysis of ACDAN fluorescence reveals water dipolar relaxation and demonstrates that mutations in two zebrafish aquaporin 0s, Aqp0a and Aqp0b, alter water state and macromolecular crowding in living lenses.	Water	166-171	major intrinsic protein of lens fiber b	Danio rerio	153-158
35049282-6	2022	The acquired knowledge about the nanoparticles" surface chemistry is used to optimize the procedure to transfer the nanoparticles into aqueous media, obtaining water-dispersible Ag2S nanoparticles that maintain excellent PL properties.	Water	160-165	angiotensin II receptor type 1	Homo sapiens	178-182
29195195-1	2018	High-value urban zones in coastal South Florida are considered particularly vulnerable to salt water intrusion into the groundwater-based, public water supplies caused by sea level rise (SLR) in combination with the low topography, existing high water table, and permeable karst substrate.	Water	95-100	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	171-174
35019917-2	2022	It exhibited an excellent selective and sensitive CHEF-based recognition of trivalent metal ions M3+ (M = Fe, Al and Cr) over mono and di-valent and other trivalent metal ions with prominent enhancement in the absorption and fluorescence intensity for Fe3+ (669-fold), Al3+ (653-fold) and Cr3+ (667-fold) upon the addition of 2.6 equivalent of these metal ions in the probe in H2O/CH3CN (7 : 3, v/v, pH 7.2).	Water	377-380	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	289-292
29795762-3	2018	We report herein the discovery and preclinical profile of a water-soluble intravenous prodrug BMS-986163 (6) and its active parent molecule BMS-986169 (5), which demonstrated high binding affinity for the GluN2B allosteric site (Ki = 4.0 nM) and selective inhibition of GluN2B receptor function (IC50 = 24 nM) in cells.	Water	60-65	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	205-211
29795762-3	2018	We report herein the discovery and preclinical profile of a water-soluble intravenous prodrug BMS-986163 (6) and its active parent molecule BMS-986169 (5), which demonstrated high binding affinity for the GluN2B allosteric site (Ki = 4.0 nM) and selective inhibition of GluN2B receptor function (IC50 = 24 nM) in cells.	Water	60-65	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	270-276
35019917-4	2022	The quantum yields of L3, (L3-Fe3+), (L3-Al3+) and (L3-Cr3+) complexes in H2O/CH3CN (7 : 3, v/v, pH 7.2) were found to be 0.0005, 0.335, 0.327 and 0.333, respectively, using rhodamine-6G as the standard.	Water	74-77	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	55-58
35163274-9	2022	In the K+-independent apoenzyme of Mycobacterium tuberculosis, K72 (K117) flips out of the active site; in the holoenzyme, K72 faces toward the active site bridging the substrates through water molecules.	Water	188-193	keratin 72	Homo sapiens	63-66
29546911-3	2018	The adsorption is exceptionally rapid, showing 100% removal of Cu2+ in 10 min, and 100% removal of Pb2+ and Cd2+ in 20 min in water with a wide range of concentrations from 0.1 to 5 mmol L-1.	Water	126-131	CD2 molecule	Homo sapiens	108-111
35163274-9	2022	In the K+-independent apoenzyme of Mycobacterium tuberculosis, K72 (K117) flips out of the active site; in the holoenzyme, K72 faces toward the active site bridging the substrates through water molecules.	Water	188-193	keratin 72	Homo sapiens	123-126
35061779-0	2022	Microbial reductions and physical characterization of chitosan flocs when using chitosan acetate as a cloth filter aid in water treatment.	Water	122-127	activation induced cytidine deaminase	Homo sapiens	115-118
29442311-3	2018	Adding H2O decreased the possibility of reactions between the reductive groups (NH) and the oxygen radical during devolatilization, which led to a decrease in NO emissions at 1000  C. However, as the furnace temperature increased, "additional" nitrogen precursors (HCN and NH3) generated by enhanced char-H2O gasification were quickly oxidized to generate a large amount of NO during char oxidation that exceeded the amount of NO reduced by NH during devolatilization.	Water	7-10	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	265-268
35055298-3	2022	SnS2 nanoparticles and thin films were explored as an adsorbent to remove organic toxic materials (Rhodamine B (RhB)) from water and an alternative to the toxic cadmium sulfide (CdS) buffer for thin-film solar cells, respectively.	Water	123-128	sodium voltage-gated channel alpha subunit 11	Homo sapiens	0-4
35087537-7	2021	Drinking the DSS-supplementing water also increased disease activity index (DAI) and serum urea nitrogen level (P <0.05), shortened colonic length (P <0.05), impaired colonic enterocyte apoptosis, cell cycle, and the ZO-1 mRNA expression (P <0.05), increased the ratio of CD11c-, CD64-, and CD169-positive cells in colon (P <0.05), and induced extensive ulcer, infiltration of inflammatory cells, and collagenous fiber hyperplasia in colon.	Water	31-36	integrin subunit alpha X	Homo sapiens	272-277
35057468-11	2022	Compared to the LS1 and LS2 groups, the HS2 group had 310-381, 250-358 and 382-655 mL more amounts of water from the total water intake (TWI), total drinking fluids and water from food (all p < 0.05), respectively.	Water	102-107	serpin family D member 1	Homo sapiens	24-27
29397219-4	2018	METHODS: The viability of hDPCs treated with leptin was examined using the water soluble tetrazolium salt-1 assay.	Water	75-80	leptin	Homo sapiens	45-51
28826121-6	2018	This water was found as two main types: calcium magnesium bicarbonate (CaMg-HCO3), which was the most represented, and sodium bicarbonate potassium (NaK-HCO3).	Water	5-10	TANK binding kinase 1	Homo sapiens	149-152
29248371-6	2018	The obtained gel with molar composition of 7.0 Na2O: 1.0 Al2O3: 4.8 SiO2: 209.4 H2O was converted by hydrothermal crystallization at 60  C to nanosized EMT/FAU zeotype and geopolymeric amorphous aluminosilicate material.	Water	80-83	IL2 inducible T cell kinase	Homo sapiens	152-155
34522949-8	2022	To simulate a rainfall, we performed spraying of the pollinated stigma with deionized water that induced ANN5 accumulation at PM.	Water	86-91	annexin 5	Arabidopsis thaliana	105-109
29561787-5	2018	In this study, the effects of H2O on pyrrole pyrolysis to form NOx precursors HCN and NH3 are investigated using the density functional theory (DFT) method.	Water	30-33	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	78-81
29561787-6	2018	The calculation results indicate that the presence of H2O can lead to the formation of both NH3 and HCN during pyrrole pyrolysis, while only HCN is formed in the absence of H2O.	Water	54-57	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	100-103
29295526-1	2017	Aquaporin-4 (AQP4) is the most abundant water channel in the brain, and its inhibition before inducing focal ischemia, using the AQP4 inhibitor TGN-020, has been showed to reduce oedema in imaging studies.	Water	40-45	aquaporin 4	Rattus norvegicus	0-11
29295526-1	2017	Aquaporin-4 (AQP4) is the most abundant water channel in the brain, and its inhibition before inducing focal ischemia, using the AQP4 inhibitor TGN-020, has been showed to reduce oedema in imaging studies.	Water	40-45	aquaporin 4	Rattus norvegicus	13-17
35221495-0	2022	Evaluation of Caspase-3 and Ki-67 expression in squamous cell hyperplasia of the stomach induced by Platycodi radix water extract in Sprague-Dawley rats.	Water	116-121	caspase 3	Rattus norvegicus	14-23
29144751-5	2017	Moreover, PdNPs/SBA-15 was an excellent catalyst for the direct arylation at the C-2 position (via C-H activation) of indole in water in the presense of a hypervalent iodine oxidant.	Water	128-133	complement C2	Homo sapiens	81-84
29111712-2	2017	In this work, we compute the adsorption energy of water on SrTiO3 using periodic Moller-Plesset second-order perturbation theory (MP2).	Water	50-55	tryptase pseudogene 1	Homo sapiens	130-133
29111712-4	2017	The MP2 ground-state adsorption energy of water on SrTiO3 (001) at one monolayer coverage is 0.9 eV on the TiO2 termination in the molecular configuration and 0.6 eV in the dissociative configuration, the corresponding results on the SrO termination being 0.9 eV for both modes of adsorption.	Water	42-47	tryptase pseudogene 1	Homo sapiens	4-7
29337418-2	2018	They share a halogenated phenyl ring (region 1) that deeply inserts into an otherwise water-filled cavity at the CD4 binding site on the gp120 surface, the so-called F43 cavity.	Water	86-91	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	137-142
29468880-0	2018	Soft/Hard-Coupled Amphiphilic Polymer Nanospheres for Water Lubrication.	Water	54-59	POC1 centriolar protein A	Homo sapiens	0-4
2642194-2	1989	When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure.	Water	124-129	neurolysin	Homo sapiens	80-83
29468880-3	2018	The influences of the monomer concentration, the copolymer nanosphere additive content, the load, and the frequency of the friction conditions on their tribological properties were studied in detail, and a probable antiwear mechanism of the soft/hard-coupled copolymer nanospheres under water lubrication was also proposed.	Water	287-292	POC1 centriolar protein A	Homo sapiens	241-245
29492505-4	2018	We identify two characteristic temperatures (Tc1 and Tc2) at which the water desorption rate changes abruptly.	Water	71-76	transcobalamin 1	Homo sapiens	45-48
29451291-1	2018	In this work, we demonstrate the synthesis and application of a novel CoII-based metal-organic framework {[Co2(Dcpp)(Bpe)0.5 (H2O)(mu2-H2O)] (Bpe)0.5}n (CoII-MOF, H4Dcpp = 4,5-bis(4"-carboxylphenyl)-phthalic acid, Bpe = 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection.	Water	126-129	complement C2	Homo sapiens	107-110
31458563-5	2018	The complex 2 crystallizes in the monoclinic symmetry with the P21/c space group in which the N-O unit of the radical coordinates with the Co ion through hydrogen bonding of a water molecule.	Water	176-181	H3 histone pseudogene 16	Homo sapiens	63-68
29520011-0	2018	Modulating the water channel AQP4 alters miRNA expression, astrocyte connectivity and water diffusion in the rodent brain.	Water	15-20	aquaporin 4	Rattus norvegicus	29-33
29520011-0	2018	Modulating the water channel AQP4 alters miRNA expression, astrocyte connectivity and water diffusion in the rodent brain.	Water	86-91	aquaporin 4	Rattus norvegicus	29-33
29520011-3	2018	We previously showed that a 24.9% decrease in AQP4 expression after in vivo silencing resulted in a 45.8% decrease in tissue water mobility as interpreted from magnetic resonance imaging apparent diffusion coefficients (ADC).	Water	125-130	aquaporin 4	Rattus norvegicus	46-50
30136499-1	2018	A quaternary ammonium functionalized MIL-101(Cr) named MIL-101(Cr)-NMe3 was synthesized and explored as a novel adsorbent for the fast removal of diclofenac sodium (DCF) in water.	Water	173-178	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	67-71
29511255-5	2018	The meltwater events point to an increased outflow of low salinity water from the Black Sea driven by rapid sea level rise &gt;1.4 m following freshwater outbursts from Lake Agassiz and the final decay of the Laurentide ice sheet.	Water	8-13	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	88-91
29511255-5	2018	The meltwater events point to an increased outflow of low salinity water from the Black Sea driven by rapid sea level rise &gt;1.4 m following freshwater outbursts from Lake Agassiz and the final decay of the Laurentide ice sheet.	Water	8-13	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	108-111
29424528-6	2018	Through the Sm-O radial distribution function and the evolution of the Sm-O distances, the present study yields a very tightly bound first rigid Sm(III) solvation shell from 2.3 to 2.9 A whose integration leads to a coordination number of 9 water molecules and a second softer solvation sphere from 3.9 to 5 A with 12 water molecules.	Water	241-246	smoothened, frizzled class receptor	Homo sapiens	12-16
29024278-3	2018	We hypothesize that osmotic diuresis induced by SGLT2 inhibition, a distinctly different diuretic mechanism than that of other diuretic classes, results in greater electrolyte-free water clearance and, ultimately, in greater fluid clearance from the interstitial fluid (IF) space than from the circulation, potentially resulting in congestion relief with minimal impact on blood volume, arterial filling and organ perfusion.	Water	181-186	solute carrier family 5 member 2	Homo sapiens	48-53
29327192-4	2018	Six PARAFAC components were highlighted in 69 raw sewage water samples: C2, C5, and C6 related to humic-like compounds, along with C1, C3, and C4 related to protein-like compounds.	Water	57-62	complement C4A (Rodgers blood group)	Homo sapiens	84-145
29545743-8	2018	Administration of the LRRK2 inhibitor PF-06447475 significantly reduced neuronal apoptosis, brain water content, and blood-brain barrier permeability 12 h after TBI and ameliorated neurological deficits 72 h after TBI, which was concomitant with decreased p38 phosphorylation and increased Drosha expression.	Water	98-103	leucine-rich repeat kinase 2	Rattus norvegicus	22-27
29414037-5	2018	Moreover, it was found that [Fe-P1]2+ is a more stable complex than [Fe-DFP]2+ and [Fe-3,4-HOPO]2+ in the gas phase and water, confirming that P1 is the strongest selective iron chelator.	Water	120-125	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	32-34
29414037-5	2018	Moreover, it was found that [Fe-P1]2+ is a more stable complex than [Fe-DFP]2+ and [Fe-3,4-HOPO]2+ in the gas phase and water, confirming that P1 is the strongest selective iron chelator.	Water	120-125	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	143-145
29535679-13	2018	In conclusion, we found that rhMFGE8 pretreatment effectively alleviated neurological deficits and decreased brain water content and apoptotic cells in the SBI model through the MFGE8/integrin-beta3 pathway, and treatment time was an important factor in achieving curative effects.	Water	115-120	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	31-36
29368776-1	2018	Gas absorption calorimetry has been employed to probe the intercation of water and carbon dioxide with transition metal ion (TM = Mn2+, Fe2+, Co2+, Cu2+, and Zn2+) exchanged zeolite A samples.	Water	73-78	complement C2	Homo sapiens	142-145
29328665-6	2018	Induction or film drainage times of a bubble at the mobile PP11-air surface were found to be more than 2 orders of magnitude shorter compared to the case of bubble and an immobile PP11-water interface.	Water	185-190	endonuclease, poly(U) specific	Homo sapiens	59-63
29328665-6	2018	Induction or film drainage times of a bubble at the mobile PP11-air surface were found to be more than 2 orders of magnitude shorter compared to the case of bubble and an immobile PP11-water interface.	Water	185-190	endonuclease, poly(U) specific	Homo sapiens	180-184
29280205-0	2018	Interstitial P-Doped CdS with Long-Lived Photogenerated Electrons for Photocatalytic Water Splitting without Sacrificial Agents.	Water	85-90	CDP-diacylglycerol synthase 1	Homo sapiens	21-24
29280205-1	2018	Photocatalytic hydrogen evolution from pure water is successfully realized by using interstitial P-doped CdS with rich S vacancies (CdS-P) as the photocatalyst in the absence of any electron sacrificial agents.	Water	44-49	CDP-diacylglycerol synthase 1	Homo sapiens	105-108
29280205-1	2018	Photocatalytic hydrogen evolution from pure water is successfully realized by using interstitial P-doped CdS with rich S vacancies (CdS-P) as the photocatalyst in the absence of any electron sacrificial agents.	Water	44-49	CDP-diacylglycerol synthase 1	Homo sapiens	132-135
28726128-1	2018	Using a time-dependent phosphorus (P) budget model for the Baltic proper, describing sources and sinks at the external borders of the water column, one may compute the e-folding time T of the adjustment of the winter surface water P concentration c 1 to abruptly changed total P supply.	Water	134-139	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	247-250
28726128-1	2018	Using a time-dependent phosphorus (P) budget model for the Baltic proper, describing sources and sinks at the external borders of the water column, one may compute the e-folding time T of the adjustment of the winter surface water P concentration c 1 to abruptly changed total P supply.	Water	225-230	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	247-250
28726128-3	2018	The P budget model, including an internal source emanating from deep anoxic bottoms, also shows that c 1e is proportional to the total P supply to the water column.	Water	151-156	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	101-104
29874739-7	2018	These findings suggest that Ag2SNPs have the potential to accelerate the photochemical degradation of DOM in surface water.	Water	117-122	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	28-31
28434263-5	2018	Zein is a water-insoluble protein from maize; Gliadin is a 70% alcohol-soluble protein from wheat and corn; legumin is a casein-like protein from leguminous seeds such as peas; lectins are glycoproteins naturally occurring in many plants that recognize specific carbohydrate residues.	Water	10-15	zein	Zea mays	0-4
29563945-11	2018	Conclusion: Patients younger than 18 months with stage 4 MYCN nonamplified neuroblastoma showed excellent outcomes, without significant late adverse effects, when treated with alternating cycles of CEDC and ICE, followed by surgery and differentiation therapy.	Water	207-210	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	57-61
29475678-3	2018	Results showed that the hypoxia continues to intensify in the deep-water basin of the South Caspian Sea.	Water	67-72	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	100-103
29354815-4	2018	When employed as a bifunctional electrode, CoP@NPMG enables high-performance water splitting with a current density of 10 mA cm-2 at cell voltages of only 1.58 V and 1.74 V in 1 M KOH and 1 M PBS, respectively.	Water	77-82	caspase recruitment domain family member 16	Homo sapiens	43-46
29402369-11	2018	The brain water content in AQP4 RNAi group [(78.8+-0.3)%] was significantly decreased as compared with that in TBI group (P &lt; 0.01).	Water	10-15	aquaporin 4	Rattus norvegicus	27-31
29380134-6	2018	The classifications in this paper are based not only on the magnitude of lake water salinity or hydrochemical analysis but also on isolation from the Baltic Sea and other sources of water.	Water	182-187	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	157-160
29390798-8	2018	Most importantly, we have quantified enhanced restriction in water dynamics around the second Fyn-binding site of the SAP due to SAP-SLAM complexation, even prior to the presence of Fyn.	Water	61-66	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	77-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-163
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	77-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	214-217
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	110-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-163
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	110-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	214-217
29371648-6	2018	This projection considers recent increase of slope convections mainly due to the salt supply via air-sea freshwater exchange and sea ice formation and decrease of open-ocean convections evidenced by reduced mixed layer depth in the northern East Sea, resulting in more bottom water and less central water formations.	Water	110-115	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	101-104
29171706-4	2018	Benefiting from the moderate CoOx species formed on the surface, which can promote the water dissociation in alkaline HER, the surface reorganization of the CoP NWs/CC realizes almost fourfold enhanced alkaline HER activity and a 180 mV decreased overpotential at 100 mA cm-2 , compared with the pristine ones.	Water	87-92	caspase recruitment domain family member 16	Homo sapiens	157-160
29103957-1	2018	Apical plasma membrane accumulation of the water channel Aquaporin-2 (AQP2) in kidney collecting duct principal cells is critical for body water homeostasis.	Water	43-48	aquaporin 2	Homo sapiens	70-74
29863081-6	2018	LTP at Schaffer collateral-CA1 pyramidal cells synapses was attenuated in the hippocampal slices from crowding-stressed rats, while administration of YKS-containing water rescued the attenuation.	Water	165-170	carbonic anhydrase 1	Rattus norvegicus	27-30
29130344-3	2018	Aprepitant and its water-soluble prodrug, fosaprepitant dimeglumine, are the most widely used NK1 RAs, with extensive clinical use worldwide.	Water	19-24	tachykinin receptor 1	Homo sapiens	94-97
29154270-7	2018	In the present study, we report that providing Ubisol-Q10 in drinking water (at a dose of ~6 mg/kg/day) reduced circulating amyloid-beta (Abeta) peptide, improved long term memory, preserved working spatial memory, and drastically inhibited Abeta plaque formation in 18-month-old transgenic mice compared to an untreated transgenic group.	Water	70-75	amyloid beta (A4) precursor protein	Mus musculus	138-143
29154270-7	2018	In the present study, we report that providing Ubisol-Q10 in drinking water (at a dose of ~6 mg/kg/day) reduced circulating amyloid-beta (Abeta) peptide, improved long term memory, preserved working spatial memory, and drastically inhibited Abeta plaque formation in 18-month-old transgenic mice compared to an untreated transgenic group.	Water	70-75	amyloid beta (A4) precursor protein	Mus musculus	241-246
29040585-13	2018	Conclusions: To the best of our knowledge, this is the first report of mcr-1-positive E. coli and blaNDM-1-carrying E. cloacae and C. freundii in hospital sewage water.	Water	162-167	metallo-beta-lactamase NDM-1	Klebsiella pneumoniae	98-106
29020656-1	2018	Four novel water-soluble Cu(II) derivatives based on the meso-10, 15, 20-Tris (N-methyl-X-pyridyl)-5-(4"-salicyloylhydrazone) metalloporphyrin ligands (X=4, M=Zn(1) Co(2); X=2, M=Zn(3), Co(4)), have been prepared and isolated.	Water	11-16	complement C2	Homo sapiens	165-170
29020656-1	2018	Four novel water-soluble Cu(II) derivatives based on the meso-10, 15, 20-Tris (N-methyl-X-pyridyl)-5-(4"-salicyloylhydrazone) metalloporphyrin ligands (X=4, M=Zn(1) Co(2); X=2, M=Zn(3), Co(4)), have been prepared and isolated.	Water	11-16	complement C4A (Rodgers blood group)	Homo sapiens	186-191
28946463-4	2018	We observed that lipase-ultrasound assisted hydrolysis of AME in the presence of triolein and water showed the highest hydrolysis conversion rate (65.3%).	Water	94-99	PAN0_003d1715	Moesziomyces antarcticus	17-23
29131636-5	2017	These nanoporous robust membranes allow for the extremely high water flux, up to 3.5 x 104 L h-1 m-2 bar-1 combined with high rejection rate for various organic molecules, capability of capturing heavy metal ions and their further reduction into metal nanoparticles for added SERS detection capability and catalytic functionalities.	Water	63-68	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	276-280
28814374-7	2017	Recently, we managed to synthesize a series of potent water-soluble and highly cell-permeable triazolyl esters of COOH-bearing PAK1-blockers such as Ketorolac, ARC (artepillin C) and CA (caffeic acid) via "Click Chemistry" that boosts their anti-cancer activity over 500-fold, mainly by increasing their cell-permeability, and one of them called 15K indeed extends the lifespan of C. elegans.	Water	54-59	Serine/threonine-protein kinase pak-1	Caenorhabditis elegans	127-131
28823424-6	2017	As primary production and phytoplankton concentration in sea water grew, so did the diversity of the microorganisms identified in bioaerosols.	Water	61-66	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	57-60
29326688-4	2017	Therefore, the aim of this study was to investigate the potential link between water-soluble cigarette smoke extract (CSE)-induced endothelial dysfunction and the function of CXCL16/CXCR6 axis on the initial attachment of leukocytes, in addition to its possible impact on COPD-associated systemic inflammation.	Water	79-84	C-X-C motif chemokine receptor 6	Homo sapiens	182-187
29111640-4	2017	In examining contact formation in air and underwater, we find that the presence of water when contact is made leads to different modes of PSA relaxation and contact formation.	Water	47-52	aminopeptidase puromycin sensitive	Homo sapiens	138-141
29111640-6	2017	Additionally, we observe that the presence of water during debonding has a more pronounced effect on the adhesive strength of the PSA when probed by a hydrophilic surface as opposed to a hydrophobic surface.	Water	46-51	aminopeptidase puromycin sensitive	Homo sapiens	130-133
29111640-7	2017	Using fingering wavelength analysis, we estimate the surface energy of the PSA in situ and find that when submerged in water, the PSA has a significantly higher surface energy compared to in air.	Water	119-124	aminopeptidase puromycin sensitive	Homo sapiens	75-78
29111640-7	2017	Using fingering wavelength analysis, we estimate the surface energy of the PSA in situ and find that when submerged in water, the PSA has a significantly higher surface energy compared to in air.	Water	119-124	aminopeptidase puromycin sensitive	Homo sapiens	130-133
29111640-8	2017	Therefore, combining the observation of different modes of contact formation, the increase in surface energy, and the importance of the surface energy of the probe, we suggest that the decrease in adhesive strength in water can be explained by the hydration of the PSA and by trapped water defects between the PSA and the probe.	Water	218-223	aminopeptidase puromycin sensitive	Homo sapiens	265-268
29111640-8	2017	Therefore, combining the observation of different modes of contact formation, the increase in surface energy, and the importance of the surface energy of the probe, we suggest that the decrease in adhesive strength in water can be explained by the hydration of the PSA and by trapped water defects between the PSA and the probe.	Water	218-223	aminopeptidase puromycin sensitive	Homo sapiens	310-313
29111640-8	2017	Therefore, combining the observation of different modes of contact formation, the increase in surface energy, and the importance of the surface energy of the probe, we suggest that the decrease in adhesive strength in water can be explained by the hydration of the PSA and by trapped water defects between the PSA and the probe.	Water	284-289	aminopeptidase puromycin sensitive	Homo sapiens	310-313
29200761-0	2017	Treatment of Palmar Hyperhidrosis with Tap Water Iontophoresis: A Randomized, Sham-Controlled, Single-Blind, and Parallel-Designed Clinical Trial.	Water	43-48	filamin B	Homo sapiens	39-42
29200761-14	2017	Conclusion: Tap water iontophoresis could be used as an effective and safe treatment modality for palmar hyperhidrosis.	Water	16-21	filamin B	Homo sapiens	12-15
29169731-3	2017	Based on screening of 70 water-ethanol extracts obtained from different parts of 65 plants we prepared a highly active phytocomposition (PC-1) containing oregano (Origanum vulgare), wild thyme (Thymus serpyllum) and coltsfoot (Tussilago farfara) aerial parts, valerian (Valeriana officinalis) leaves and little-leaf linden (Tilia cordata) flowers.	Water	25-30	polycystin 1, transient receptor potential channel interacting	Homo sapiens	137-141
28715878-4	2017	The CdS loading and its corresponding water splitting performance could demonstrate the effect of La doping.	Water	38-43	CDP-diacylglycerol synthase 1	Homo sapiens	4-7
28914497-6	2017	Another important source for hydrogen is hydrogen sulfide, which is abundantly found in Black Sea deep water.	Water	103-108	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	94-97
28914497-7	2017	Hydrogen produced by electrolysis of Black Sea deep water can also be used in hydrogen fuel cells.	Water	52-57	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	43-46
29048879-0	2017	Near-Infrared Fluorescent Probe with Remarkable Large Stokes Shift and Favorable Water Solubility for Real-Time Tracking Leucine Aminopeptidase in Living Cells and In Vivo.	Water	81-86	LAP	Homo sapiens	121-143
28953360-0	2017	Nanoscale Structural Switching of Plasmonic Nanograin Layers on Hydrogel Colloidal Monolayers for Highly Sensitive and Dynamic SERS in Water with Areal Signal Reproducibility.	Water	135-140	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	127-131
28927270-11	2017	When the HFHC meal was consumed with water there was an increase in some inflammatory pathways such as the Fc-gamma receptor dependent phagocytosis and the complement cascade, but the immune system as a whole was not significantly altered.	Water	37-42	Fc gamma receptor Ia	Homo sapiens	107-124
28728382-16	2017	Both 1 mug/mL and 5 mug/mL of TCMF water extraction increased MyHC IIa, MyHC IIb, and MyHC IIx mRNA expression in porcine myocytes (p&lt;0.05), while MyHC I mRNA expression in porcine myocytes was decreased by 5 mug/mL TCMF water extraction (p&lt;0.05).	Water	35-40	myosin-2	Sus scrofa	62-70
28728382-16	2017	Both 1 mug/mL and 5 mug/mL of TCMF water extraction increased MyHC IIa, MyHC IIb, and MyHC IIx mRNA expression in porcine myocytes (p&lt;0.05), while MyHC I mRNA expression in porcine myocytes was decreased by 5 mug/mL TCMF water extraction (p&lt;0.05).	Water	35-40	myosin-4	Sus scrofa	72-80
28728382-16	2017	Both 1 mug/mL and 5 mug/mL of TCMF water extraction increased MyHC IIa, MyHC IIb, and MyHC IIx mRNA expression in porcine myocytes (p&lt;0.05), while MyHC I mRNA expression in porcine myocytes was decreased by 5 mug/mL TCMF water extraction (p&lt;0.05).	Water	35-40	myosin heavy chain 3	Sus scrofa	62-66
28442379-1	2017	Water soluble matrix metalloproteinases (MMPs) have been regarded as diffusing freely in the extracellular matrix.	Water	0-5	matrix metallopeptidase 7	Homo sapiens	41-45
28843063-4	2017	An emulsion method is utilized to prepare a microparticle system that comprises phase-change materials with a nearly constant temperature of phase transitions to encapsulate sodium hydrosulfide (NaHS), a highly water-labile H2S donor.	Water	211-216	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	224-227
29568419-2	2017	The formation of nanoparticles (PF-HQ) containing hydrophobic pockets via three-dimensional growth of a polymeric backbone in a higher water fraction (THF : H2O = 1 : 9) was observed.	Water	135-140	thin fur	Mus musculus	151-154
28959817-4	2017	When employed as a photocatalyst for water splitting, the obtained best composite (5% Ni2P-CdS/g-C3N4) displayed dramatically enhanced hydrogen evolution activity at the rate of 44 450 mumol h-1 g-1, which was about 27 times higher than that of pure CdS (1668 mumol h-1 g-1).	Water	37-42	CDP-diacylglycerol synthase 1	Homo sapiens	91-94
28959817-4	2017	When employed as a photocatalyst for water splitting, the obtained best composite (5% Ni2P-CdS/g-C3N4) displayed dramatically enhanced hydrogen evolution activity at the rate of 44 450 mumol h-1 g-1, which was about 27 times higher than that of pure CdS (1668 mumol h-1 g-1).	Water	37-42	CDP-diacylglycerol synthase 1	Homo sapiens	250-253
28972224-0	2017	Highly enhanced visible light water splitting of CdS by green to blue upconversion.	Water	30-35	CDP-diacylglycerol synthase 1	Homo sapiens	49-52
28972224-4	2017	The enhancement factor of the photocatalytic activity induced by the UC was estimated to be approximately 3, which indicates that the green to blue UC by the encapsulated Pt(OEP)/DPA can enhance the water splitting activity of CdS significantly.	Water	199-204	CDP-diacylglycerol synthase 1	Homo sapiens	227-230
28972224-5	2017	The reduced graphene oxide (rGO) attached to the CdS photocatalyst further enhances the water splitting activity via effective charge separation and suppressed recombination.	Water	88-93	CDP-diacylglycerol synthase 1	Homo sapiens	49-52
28991687-5	2017	There was a negative linear association between CSF opening pressure and CSF protein: CSF protein decreased by 0.18mg/dL for each 1cm H2O increase in CSF opening pressure (p&lt;0.001).	Water	134-137	colony stimulating factor 2	Homo sapiens	48-51
28991687-5	2017	There was a negative linear association between CSF opening pressure and CSF protein: CSF protein decreased by 0.18mg/dL for each 1cm H2O increase in CSF opening pressure (p&lt;0.001).	Water	134-137	colony stimulating factor 2	Homo sapiens	73-76
28991687-5	2017	There was a negative linear association between CSF opening pressure and CSF protein: CSF protein decreased by 0.18mg/dL for each 1cm H2O increase in CSF opening pressure (p&lt;0.001).	Water	134-137	colony stimulating factor 2	Homo sapiens	73-76
28991687-5	2017	There was a negative linear association between CSF opening pressure and CSF protein: CSF protein decreased by 0.18mg/dL for each 1cm H2O increase in CSF opening pressure (p&lt;0.001).	Water	134-137	colony stimulating factor 2	Homo sapiens	73-76
31966366-11	2017	Overexpression of miR-21 or knockdown of PDCD4 promoted ATII cell proliferation and inhibited ATII cell apoptosis after treatment with H2O2.	Water	135-139	microRNA 21	Homo sapiens	18-24
29104484-1	2017	Background: Aquaporin 5 (AQP5) is most likely the primary water channel in the human nasal mucosa and acts as a key tight junction protein.	Water	58-63	aquaporin 5	Homo sapiens	12-23
29104484-1	2017	Background: Aquaporin 5 (AQP5) is most likely the primary water channel in the human nasal mucosa and acts as a key tight junction protein.	Water	58-63	aquaporin 5	Homo sapiens	25-29
30023750-1	2017	The binding interaction of a biocompatible water-soluble polycationic two-photon fluorophore (Ant-PIm) toward human serum albumin (HSA) was thoroughly investigated under simulated physiological conditions using a combination of steady-state, time-resolved, and two-photon excited fluorescence techniques.	Water	43-48	solute carrier family 25 member 6	Homo sapiens	94-97
28677385-0	2017	Minimal Nucleation State of alpha-Synuclein Is Stabilized by Dynamic Threonine-Water Networks.	Water	79-84	synuclein alpha	Homo sapiens	28-43
28931009-1	2017	Regulation of our water homeostasis is fine-tuned by dynamic translocation of Aquaporin-2 (AQP2)-bearing vesicles to and from the plasma membrane of renal principal cells.	Water	18-23	aquaporin 2	Mus musculus	78-89
28931009-1	2017	Regulation of our water homeostasis is fine-tuned by dynamic translocation of Aquaporin-2 (AQP2)-bearing vesicles to and from the plasma membrane of renal principal cells.	Water	18-23	aquaporin 2	Mus musculus	91-95
28535433-5	2017	A resistance-in-series analysis further reveals that the coating was highly permeable to water but highly resistant to EDCs, leading to an EDC selectivity that was an order of magnitude greater than those of the bare PDA coating and the base membrane NF90.	Water	89-94	interleukin enhancer binding factor 3	Homo sapiens	251-255
28782951-13	2017	The intercalated material of MoS4-LDH is very promising as a highly effective filter for decontamination of water with toxic Se(IV)/Se(VI) oxoanions along with heavy metals such as Hg2+, Cd2+, and Cu2+.	Water	108-113	CD2 molecule	Homo sapiens	187-190
28837198-2	2017	Long-range surface plasmon resonance (LR-SPR) was generated at the top Au/water interface, which also resulted in a long-range surface-enhanced Raman scattering (LR-SERS) effect.	Water	74-79	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	165-169
28836776-5	2017	Ru2(mu-Cl) converted slowly (10-4 s-1) to Ru2(mu-OH), and further Ru2(mu-OH) converted very slowly (10-6 s-1) to Ru2(OH)(OH2) by the insertion of water to reach equilibrium at pH 8.5-12.3.	Water	121-124	doublecortin domain containing 2	Homo sapiens	0-3
28836776-5	2017	Ru2(mu-Cl) converted slowly (10-4 s-1) to Ru2(mu-OH), and further Ru2(mu-OH) converted very slowly (10-6 s-1) to Ru2(OH)(OH2) by the insertion of water to reach equilibrium at pH 8.5-12.3.	Water	121-124	doublecortin domain containing 2	Homo sapiens	66-75
28836776-5	2017	Ru2(mu-Cl) converted slowly (10-4 s-1) to Ru2(mu-OH), and further Ru2(mu-OH) converted very slowly (10-6 s-1) to Ru2(OH)(OH2) by the insertion of water to reach equilibrium at pH 8.5-12.3.	Water	146-151	doublecortin domain containing 2	Homo sapiens	0-3
28836776-5	2017	Ru2(mu-Cl) converted slowly (10-4 s-1) to Ru2(mu-OH), and further Ru2(mu-OH) converted very slowly (10-6 s-1) to Ru2(OH)(OH2) by the insertion of water to reach equilibrium at pH 8.5-12.3.	Water	146-151	doublecortin domain containing 2	Homo sapiens	66-75
28836776-6	2017	On the basis of density functional theory (DFT) calculations, Ru2(OH)(OH2) was predicted to be thermodynamically stable by 13.3 kJ mol-1 in water compared to Ru2(mu-OH) because of the specially stabilized core structure by multiple hydrogen-bonding interactions involving aquo, hydroxo, and L backbone ligands.	Water	70-73	doublecortin domain containing 2	Homo sapiens	62-65
28836776-6	2017	On the basis of density functional theory (DFT) calculations, Ru2(OH)(OH2) was predicted to be thermodynamically stable by 13.3 kJ mol-1 in water compared to Ru2(mu-OH) because of the specially stabilized core structure by multiple hydrogen-bonding interactions involving aquo, hydroxo, and L backbone ligands.	Water	70-73	doublecortin domain containing 2	Homo sapiens	158-167
28836776-6	2017	On the basis of density functional theory (DFT) calculations, Ru2(OH)(OH2) was predicted to be thermodynamically stable by 13.3 kJ mol-1 in water compared to Ru2(mu-OH) because of the specially stabilized core structure by multiple hydrogen-bonding interactions involving aquo, hydroxo, and L backbone ligands.	Water	140-145	doublecortin domain containing 2	Homo sapiens	62-65
28836776-9	2017	The kinetic data including activation parameters suggest that the associative mechanism for the insertion of water to the RuII(mu-OH)RuII core of Ru2(mu-OH) at pH 8.5-12.3 alters the interchange mechanism for the insertion of an OH- ion to the core above pH 13.4 because of relatively stronger nucleophilic attack of OH- ions.	Water	109-114	doublecortin domain containing 2	Homo sapiens	146-155
28836776-10	2017	The hypothesized p,p-[Ru2(tpy)2L(mu-OH2)]4+ and p,p-[Ru2(tpy)2L(OH2)2]4+ formed by protonation from Ru2(mu-OH) and Ru2(OH)(OH2) were predicted to be unstable by 71.3 and 112.4 kJ mol-1 compared to Ru2(mu-OH) and Ru2(OH)(OH2), respectively.	Water	36-39	doublecortin domain containing 2	Homo sapiens	22-25
28836776-10	2017	The hypothesized p,p-[Ru2(tpy)2L(mu-OH2)]4+ and p,p-[Ru2(tpy)2L(OH2)2]4+ formed by protonation from Ru2(mu-OH) and Ru2(OH)(OH2) were predicted to be unstable by 71.3 and 112.4 kJ mol-1 compared to Ru2(mu-OH) and Ru2(OH)(OH2), respectively.	Water	36-39	doublecortin domain containing 2	Homo sapiens	53-56
28836776-10	2017	The hypothesized p,p-[Ru2(tpy)2L(mu-OH2)]4+ and p,p-[Ru2(tpy)2L(OH2)2]4+ formed by protonation from Ru2(mu-OH) and Ru2(OH)(OH2) were predicted to be unstable by 71.3 and 112.4 kJ mol-1 compared to Ru2(mu-OH) and Ru2(OH)(OH2), respectively.	Water	36-39	doublecortin domain containing 2	Homo sapiens	100-109
28836776-10	2017	The hypothesized p,p-[Ru2(tpy)2L(mu-OH2)]4+ and p,p-[Ru2(tpy)2L(OH2)2]4+ formed by protonation from Ru2(mu-OH) and Ru2(OH)(OH2) were predicted to be unstable by 71.3 and 112.4 kJ mol-1 compared to Ru2(mu-OH) and Ru2(OH)(OH2), respectively.	Water	36-39	doublecortin domain containing 2	Homo sapiens	53-56
28836776-10	2017	The hypothesized p,p-[Ru2(tpy)2L(mu-OH2)]4+ and p,p-[Ru2(tpy)2L(OH2)2]4+ formed by protonation from Ru2(mu-OH) and Ru2(OH)(OH2) were predicted to be unstable by 71.3 and 112.4 kJ mol-1 compared to Ru2(mu-OH) and Ru2(OH)(OH2), respectively.	Water	36-39	doublecortin domain containing 2	Homo sapiens	197-206
28836776-10	2017	The hypothesized p,p-[Ru2(tpy)2L(mu-OH2)]4+ and p,p-[Ru2(tpy)2L(OH2)2]4+ formed by protonation from Ru2(mu-OH) and Ru2(OH)(OH2) were predicted to be unstable by 71.3 and 112.4 kJ mol-1 compared to Ru2(mu-OH) and Ru2(OH)(OH2), respectively.	Water	36-39	doublecortin domain containing 2	Homo sapiens	53-56
28836776-11	2017	The reverse reactions of Ru2(mu-OH), Ru2(OH)(OH2), and Ru2(OH)2 to Ru2(mu-Cl) below pH 5 could be caused by lowering the core charge by protonation of the mu-OH- or OH- ligand.	Water	45-48	doublecortin domain containing 2	Homo sapiens	25-34
28836776-11	2017	The reverse reactions of Ru2(mu-OH), Ru2(OH)(OH2), and Ru2(OH)2 to Ru2(mu-Cl) below pH 5 could be caused by lowering the core charge by protonation of the mu-OH- or OH- ligand.	Water	45-48	doublecortin domain containing 2	Homo sapiens	25-28
28836776-11	2017	The reverse reactions of Ru2(mu-OH), Ru2(OH)(OH2), and Ru2(OH)2 to Ru2(mu-Cl) below pH 5 could be caused by lowering the core charge by protonation of the mu-OH- or OH- ligand.	Water	45-48	doublecortin domain containing 2	Homo sapiens	37-40
28836776-11	2017	The reverse reactions of Ru2(mu-OH), Ru2(OH)(OH2), and Ru2(OH)2 to Ru2(mu-Cl) below pH 5 could be caused by lowering the core charge by protonation of the mu-OH- or OH- ligand.	Water	45-48	doublecortin domain containing 2	Homo sapiens	37-40
28520217-8	2017	Alterations in the expression of the AQP4/Kir4.1 complex can disrupt water and ion homeostasis, which may influence brain development and facilitate brain oedema formation This may be especially unfavourable during the first weeks of life.	Water	69-74	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	42-48
28521162-2	2017	Organophosphorous insecticides are common drinking water contaminants, with 12 different compounds of this class being found on the US EPA"s most recent Candidate Contaminant List (CCL4).	Water	51-56	C-C motif chemokine ligand 4	Homo sapiens	181-185
28326667-2	2017	Its clinical efficacy is in principle due to impaired vasopressin-regulated water reabsorption via aquaporin-2 (AQP2).	Water	76-81	aquaporin 2	Homo sapiens	99-110
28326667-2	2017	Its clinical efficacy is in principle due to impaired vasopressin-regulated water reabsorption via aquaporin-2 (AQP2).	Water	76-81	aquaporin 2	Homo sapiens	112-116
28326667-3	2017	Nevertheless, no direct in vitro evidence that tolvaptan prevents AQP2-mediated water transport, nor that this pathway is targeted in vivo in patients with syndrome of inappropriate antidiuresis (SIAD) has been provided.	Water	80-85	aquaporin 2	Homo sapiens	66-70
28759052-3	2017	Here we show that supraphysiological levels of D-mannose safely achievable by drinking-water supplementation suppressed immunopathology in mouse models of autoimmune diabetes and airway inflammation, and increased the proportion of Foxp3+ regulatory T cells (Treg cells) in mice.	Water	87-92	forkhead box P3	Mus musculus	232-237
28546106-1	2017	Epalrestat (EPL) is a water-insoluble drug (14muM) that inhibits aldose reductase.	Water	22-27	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	65-81
28820214-12	2017	The design, testing and successful optimisation of the operation of the biphasic electrolysis cell under dark conditions with Cp2*Fe(II) lays the foundation for the achievement of photo-induced biphasic water electrolysis at low overpotentials using another metallocene, decamethylrutheneocene (Cp2*Ru(II)).	Water	203-208	ceruloplasmin	Homo sapiens	295-298
28692195-3	2017	Iron-doped cobalt phosphate borate nanoarray on carbon cloth (Fe-Co-Pi-Bi/CC) derived from iron-doped cobalt phosphide on CC (Fe-CoP/CC) through oxidative polarization behaves as a highly active bimetallic electrocatalyst for water oxidation with an overpotential of 382 mV to afford a catalytic current density of 10 mA cm-2 in 0.1 m potassium borate (K-Bi, pH 9.2).	Water	226-231	caspase recruitment domain family member 16	Homo sapiens	129-132
28692195-5	2017	A two-electrode water electrolyzer incorporating Fe-Co-Pi-Bi/CC as anode and Fe-CoP/CC as cathode achieves 10 mA cm-2 water-splitting current at a cell voltage of 1.95 V with strong long-term electrochemical durability.	Water	16-21	caspase recruitment domain family member 16	Homo sapiens	80-83
28692195-5	2017	A two-electrode water electrolyzer incorporating Fe-Co-Pi-Bi/CC as anode and Fe-CoP/CC as cathode achieves 10 mA cm-2 water-splitting current at a cell voltage of 1.95 V with strong long-term electrochemical durability.	Water	118-123	caspase recruitment domain family member 16	Homo sapiens	80-83
28743184-10	2017	With low solubility of LiF in water, this protection layer also allows LixSi to be stable in humid air (~40% relative humidity).	Water	30-35	LIF interleukin 6 family cytokine	Homo sapiens	23-26
28489258-6	2017	The H2 S donor based on water-soluble polymer was applied in photocontrolled inhibition of P-selectin expression on human platelets and subsequent regulation of platelet aggregation.	Water	24-29	selectin P	Homo sapiens	91-101
28731705-8	2017	Block copolymers with PEG as a nonresponsive water-soluble block can self-assemble into well-defined polymersomes with narrow size distribution.	Water	45-50	progestagen associated endometrial protein	Homo sapiens	22-25
28761287-3	2017	Loss or downregulation of FLG has been shown to result in a weak stratum corneum, which causes water loss and increases the possibility of skin barrier-related seizure.	Water	95-100	filaggrin	Homo sapiens	26-29
28092075-3	2017	Addition of 20 (3) and 40 (6) mg/L (mg/kg BW) of boron to drinking water significantly increased rat serum IgG concentrations, splenic IFN-gamma and IL-4 expression as well as the number of splenic CD3+, CD4+ and proliferating cell nuclear antigen (PCNA)+ cells.	Water	67-72	interferon gamma	Rattus norvegicus	135-144
28212525-5	2017	Starting at 12 weeks after tamoxifen treatment, Gpx4BIKO mice exhibited significant deficits in spatial learning and memory function versus Control mice as determined by the Morris water maze task.	Water	181-186	glutathione peroxidase 4	Mus musculus	48-52
28656681-0	2017	In Situ Derived Co B Nanoarray: A High-Efficiency and Durable 3D Bifunctional Electrocatalyst for Overall Alkaline Water Splitting.	Water	115-120	metabolism of cobalamin associated B	Homo sapiens	16-20
28671221-3	2017	In sodium borate buffer at pH 9.20, this complex decomposed to give a Cu(OH)2/Cu2O-based thin film on FTO that catalyzes both hydrogen production and water oxidation.	Water	150-155	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	102-105
28525373-7	2017	CONCLUSIONS: Liquid water metabolic abnormalities and intestine permeability alteration might be the mechanism of IBS by down-regulating AQP1, AQP3 and AQP8 via NF-kappaB pathway.	Water	20-25	aquaporin 3 (Gill blood group)	Rattus norvegicus	143-147
28262366-11	2017	Three water savings options are assessed for their impact on energy and CO2e emissions reductions.	Water	6-11	complement C2	Homo sapiens	72-75
28613810-0	2017	MOF-Derived Formation of Ni2P-CoP Bimetallic Phosphides with Strong Interfacial Effect toward Electrocatalytic Water Splitting.	Water	111-116	caspase recruitment domain family member 16	Homo sapiens	30-33
28613817-1	2017	Characterizing the influence of fragment crystallization (Fc) and antigen-binding fragment (Fab) on monoclonal antibody (mAb) adsorption at the air/water interface is an important step to understanding liquid mAb drug product stability during manufacture, shipping, and storage.	Water	148-153	FA complementation group B	Homo sapiens	92-95
28613817-2	2017	Here, neutron reflection is used to study the air/water adsorption of a mAb and its Fc and Fab fragments.	Water	50-55	FA complementation group B	Homo sapiens	91-94
27956591-0	2017	Novel Molecular Spectroscopic Multimethod Approach for Monitoring Water Absorption/Desorption Kinetics of CAD/CAM Poly(Methyl Methacrylate) Prosthodontics.	Water	66-71	aconitate decarboxylase 1	Homo sapiens	106-113
27956591-1	2017	Water absorbed to poly(methyl methacrylate) (PMMA)-based CAD/CAM (computer-assisted design/computer-assisted manufacturing) prosthodontics can alter their properties including hardness and stability.	Water	0-5	aconitate decarboxylase 1	Homo sapiens	57-64
28000372-4	2017	ADMC and ADMP reacted with 1,3-dicarbonyl compounds under mild basic conditions to give 2-diazo-1,3-dicarbonyl compounds in high yields, which were easily isolated in virtue of the high water solubility of the by-products.	Water	186-191	serine palmitoyltransferase small subunit B	Homo sapiens	9-13
28252808-7	2017	In particular, the well water samples contain very little or no ethane and propane (C1/C2+C3 molar ratio &gt;453), unlike what would be expected in an oil province, but they also display relatively heavier delta13 Cmethane (&gt;-55%) and deltaDmethane (&gt;-180%).	Water	24-29	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	84-92
28727979-7	2017	An increase in PLA2 from 7.5 to 15 cm H2O resulted in a 4.9-fold increase in Kf2/Kf1 during LVt and a 4.8-fold increase during STVt.	Water	38-41	ring finger protein 103	Rattus norvegicus	81-84
28604880-5	2017	The Pd : PPh3 : OH2 1 : 1 : 1 reaction of the polymer produces cis-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], which isomerizes to trans-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], with water O-coordinated to Pd and making hydrogen bonds to the two SO2 groups as seen in its X-ray structure.	Water	162-167	protein phosphatase 4 catalytic subunit	Homo sapiens	9-13
28604880-5	2017	The Pd : PPh3 : OH2 1 : 1 : 1 reaction of the polymer produces cis-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], which isomerizes to trans-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], with water O-coordinated to Pd and making hydrogen bonds to the two SO2 groups as seen in its X-ray structure.	Water	162-167	protein phosphatase 4 catalytic subunit	Homo sapiens	91-95
28604880-5	2017	The Pd : PPh3 : OH2 1 : 1 : 1 reaction of the polymer produces cis-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], which isomerizes to trans-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], with water O-coordinated to Pd and making hydrogen bonds to the two SO2 groups as seen in its X-ray structure.	Water	162-167	protein phosphatase 4 catalytic subunit	Homo sapiens	91-95
28466599-3	2017	Pyrolysis of a nanocubic prussian blue analogue precursor (Km Mnx [Co(CN)6 ]y  n H2 O) embedded in a bisphenol A and aniline-based pBO led to the formation of a N-doped carbon matrix modified with Mnx Coy Oz nanocubes.	Water	81-85	keratin 86	Homo sapiens	62-65
28466599-3	2017	Pyrolysis of a nanocubic prussian blue analogue precursor (Km Mnx [Co(CN)6 ]y  n H2 O) embedded in a bisphenol A and aniline-based pBO led to the formation of a N-doped carbon matrix modified with Mnx Coy Oz nanocubes.	Water	81-85	keratin 86	Homo sapiens	197-200
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Water	107-112	fatty acid binding protein 6	Rattus norvegicus	166-171
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Water	107-112	solute carrier family 4 member 10	Rattus norvegicus	198-205
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Water	107-112	aquaporin 3 (Gill blood group)	Rattus norvegicus	210-214
28381812-0	2017	A Simple, Enzymatic Biotransformation Method Using Fresh Green Tea Leaves Efficiently Generates Theaflavin-Containing Fermentation Water That Has Potent Physiological Functions in Mice and Humans.	Water	131-136	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	63-66
28381812-2	2017	To produce theaflavin-containing fermentation water on a large scale, we have developed a simple, inexpensive, and selective enzymatic biotransformation method to obtain sufficient levels from fresh green tea leaves.	Water	46-51	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	205-208
28381812-6	2017	Thus, we showed that theaflavin-containing fermentation water can be efficiently generated from fresh green tea leaves and demonstrated its significantly potent effects in vivo.	Water	56-61	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	108-111
27620834-5	2017	AtPIP2;2 (93% identical to AtPIP2;1) similarly increased water permeability but not ionic conductance.	Water	57-62	plasma membrane intrinsic protein 2	Arabidopsis thaliana	0-8
28588509-11	2017	CPD 1 also suppressed drinking induced by isoproterenol and by water deprivation without affecting normative drinking behavior.	Water	63-68	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	Mus musculus	0-5
28381088-3	2017	Some of these samples were found to possess solubility transitions in water, where the temperature of these transitions varied with ELP concentration, nature of the methionine alkylating group, and nature of the sulfonium counterions.	Water	70-75	nuclear receptor subfamily 5 group A member 1	Homo sapiens	132-135
28243845-1	2017	OBJECTIVE: A new method of delay time estimation was proposed to measure precise cerebral blood flow (CBF) and arterial-to-capillary blood volume (V 0) using 15O-water PET.	Water	162-167	CCAAT enhancer binding protein zeta	Homo sapiens	102-105
28238838-7	2017	The uniqueness of beta-CD was reinforced by the observation that none of the other cyclodextrin variants [alpha-CD and HP-beta-CD] used was as effective, in spite of these possessing better water solubility.	Water	190-195	adrenocortical dysplasia	Mus musculus	18-25
28088462-19	2017	CONCLUSIONS: In steatotic livers of mice, hypoxia up-regulates expression of HIF1A, which reduces expression of AQP8 and concentrates biliary lipids via suppression of water secretion from hepatocytes.	Water	168-173	hypoxia inducible factor 1, alpha subunit	Mus musculus	77-82
28092126-10	2017	FLO solution prepared with either cooled boiled water or tap water is an alternative if administered immediately.	Water	61-66	filamin B	Homo sapiens	57-60
28092112-1	2017	BACKGROUND AND AIM: Urinary aquaporin-2 (AQP2) is a parameter of water transport in the principal cells in the distal part of the nephron and involved in water retention in cirrhosis and may be a marker of renal function.	Water	65-70	aquaporin 2	Homo sapiens	28-39
28092112-1	2017	BACKGROUND AND AIM: Urinary aquaporin-2 (AQP2) is a parameter of water transport in the principal cells in the distal part of the nephron and involved in water retention in cirrhosis and may be a marker of renal function.	Water	65-70	aquaporin 2	Homo sapiens	41-45
29204733-7	2017	The cytotoxic activity of boiled water extract of cultivated tuber against a human lung cancer cell line (A549) was 65.50 +- 2.12 microg mL-1 and against a human breast cancer cell line (MCF7) was 19.35 +- 0.11 microg mL-1.	Water	33-38	L1 cell adhesion molecule	Mus musculus	137-141
29204733-7	2017	The cytotoxic activity of boiled water extract of cultivated tuber against a human lung cancer cell line (A549) was 65.50 +- 2.12 microg mL-1 and against a human breast cancer cell line (MCF7) was 19.35 +- 0.11 microg mL-1.	Water	33-38	L1 cell adhesion molecule	Mus musculus	218-222
29204733-8	2017	beta-D-glucan extract from the purification of boiled water extract of cultivated tuber showed cytotoxic activity at 57.78 +- 2.29 microg mL-1 against A549 and 33.50 +- 1.41 microg mL-1 against MCF7.	Water	54-59	L1 cell adhesion molecule	Mus musculus	138-142
29204733-8	2017	beta-D-glucan extract from the purification of boiled water extract of cultivated tuber showed cytotoxic activity at 57.78 +- 2.29 microg mL-1 against A549 and 33.50 +- 1.41 microg mL-1 against MCF7.	Water	54-59	L1 cell adhesion molecule	Mus musculus	181-185
28744670-7	2017	Our data shed new light on the crucial role of HuR as a stabilizing factor for the MR transcript and provide evidence for a short autoregulatory loop in which expression of a nuclear receptor transcriptionally regulating water and sodium balance is controlled by osmotic tone.	Water	221-226	ELAV like RNA binding protein 1	Homo sapiens	47-50
28768187-3	2017	The organization of Mb colloids in BSA characterized using dilational rheological parameters show that the Mb colloids are elastic and the strong adsorbed water layers on the surface restrict the deformation, regulated by the viscoelastic surface layer.	Water	155-160	myoglobin	Homo sapiens	20-22
29296571-0	2017	Water extract of Uncaria sinensis suppresses RANKL-induced bone loss by attenuating osteoclast differentiation and bone resorption.	Water	0-5	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	45-50
29296571-7	2017	Results: We found that water extract of the hooks and stems of U. sinensis (WEUS) inhibits RANKL-induced differentiation of murine bone marrow macrophages and RAW264.7 cells into osteoclasts.	Water	23-28	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	91-96
28482648-6	2017	The RTA approach developed here can be used as a suitable hydrogenation process for TiO2 nanorods/FTO system for important applications such as photocatalysis, hydrogen generation from water splitting and solar energy conversion.	Water	185-190	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	98-101
28913790-0	2017	Delivery of HSP90 Inhibitor Using Water Soluble Polymeric Conjugates with High Drug Payload.	Water	34-39	heat shock protein 90 alpha family class A member 1	Homo sapiens	12-17
28913790-4	2017	METHODS: We developed a simplified synthetic strategy to prepare polyethylene glycol based water-soluble polymeric system for model HSP90 inhibitor geldanamycin (GDM).	Water	91-96	heat shock protein 90 alpha family class A member 1	Homo sapiens	132-137
28913790-10	2017	CONCLUSION: Water-soluble polymeric conjugate with high drug content was synthesized that exhibited in-vitro growth inhibitory activity similar to small molecular weight HSP90 inhibitor.	Water	12-17	heat shock protein 90 alpha family class A member 1	Homo sapiens	170-175
29196744-8	2017	By combining this system with the Drosophila genetics tools, we could confirm a role for ppk28 and DopR1 in promoting water consumption, and through functional investigation of RNAseq data from dehydrated animals, we found DopR1 expression in the mushroom body was sufficient to drive consumption and enhance water taste sensitivity.	Water	118-123	pickpocket 28	Drosophila melanogaster	89-94
29186911-2	2017	The process of targeting the water channel aquaporin-2 (AQP2) on the apical plasma membrane of the collecting duct (CD) principal cells is mainly regulated by the antidiuretic peptide hormone arginine vasopressin (AVP), which is responsible for the maintenance of water homeostasis.	Water	29-34	aquaporin 2	Homo sapiens	56-60
29186911-3	2017	Recently, much attention has been focused on the local factors modulating renal water reabsorption by AQP2 in the collecting ducts, especially prostaglandin E2 (PGE2).	Water	80-85	aquaporin 2	Homo sapiens	102-106
29178881-4	2017	METHODS AND RESULTS: An inducible double transgenic (DTg) mouse model was developed in which cardiac-specific fetal expression of a constitutively active form of human MEK1 (aMEK1) was induced primarily in the atrium via the withdrawal of doxycycline from the drinking water of pregnant mice.	Water	269-274	mitogen-activated protein kinase kinase 1	Homo sapiens	168-172
29155857-1	2017	The final adjustment of urine volume occurs in the inner medullary collecting duct (IMCD), chiefly mediated by the water channel aquaporin 2 (AQP2).	Water	115-120	aquaporin 2	Mus musculus	142-146
29155857-2	2017	With vasopressin stimulation, AQP2 accumulation in the apical plasma membrane of principal cells allows water reabsorption from the lumen.	Water	104-109	aquaporin 2	Mus musculus	30-34
28770827-0	2017	Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy.	Water	95-100	poly [ADP-ribose] polymerase 1	Cricetulus griseus	40-69
28128004-2	2017	We coined the term "long-acting slow effective release ART" (LASER ART) to highlight the required formulation properties of slow drug dissolution, poor water-solubility, bioavailability, little-to-no off-target toxicities and improved regimen adherence.	Water	152-157	artemin	Homo sapiens	55-59
29170709-8	2017	When analyzing the changes in body water before and after heat exposure, POST values for BIS were significantly higher than PRE (all p&lt;0.001; TBW=0.6+-0.8kg; ECW=0.4+-0.3kg; ICW=0.3+-0.6kg).	Water	35-40	solute carrier family 35 member G1	Homo sapiens	73-77
28675505-5	2017	Thermodynamic analysis suggests a hydrophobic interaction associated with the displacement of water from the cavity of the CD by the beta-lap.	Water	94-99	LAP	Homo sapiens	138-141
29731528-1	2017	The sea surface microlayer (SML) is the uppermost layer of the water column that links the ocean and atmosphere.	Water	63-68	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	4-7
29111814-2	2017	Here, we report an activation of ATM/ATR-dependent signaling pathway also as a mechanism for the cancer cell growth inhibition induced by the supernatant fraction of the water-soluble extract from sarsaparilla (SW).	Water	170-175	ATM serine/threonine kinase	Homo sapiens	33-36
29750207-3	2017	The conventional GTPase mechanism such as in H-Ras requires a conserved glutamine (Q64) in the switch-II region of RheB to align the catalytic water molecule for efficient GTP hydrolysis.	Water	143-148	HRas proto-oncogene, GTPase	Homo sapiens	45-50
29070864-0	2017	Plasmonic nanohole array for enhancing the SERS signal of a single layer of graphene in water.	Water	88-93	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	43-47
29070864-1	2017	We numerically design and experimentally test a SERS-active substrate for enhancing the SERS signal of a single layer of graphene (SLG) in water.	Water	139-144	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	48-52
29070864-1	2017	We numerically design and experimentally test a SERS-active substrate for enhancing the SERS signal of a single layer of graphene (SLG) in water.	Water	139-144	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	88-92
28807355-11	2017	Moreover, treatment with H2-rich water decreased the levels of oxidative DNA damage markers such as phosphorylated histone H2AX and 8-hydroxy-2"-deoxyguanosine, and senescence markers such as cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase inhibitor 1, and beta-galactosidase in the CS-exposed mice.	Water	33-38	galactosidase, beta 1	Mus musculus	271-289
28353341-2	2017	Films of the framework were grown on a conductive FTO substrate and showed a high catalytic current upon application of cathodic potentials and achieved high H2O/H2O2 selectivity.	Water	158-161	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	50-53
28776779-6	2017	Both non-covalent and coordinative Aubipy-AQP3 adducts were simulated to probe their role in the modulation of water channel functionality.	Water	111-116	aquaporin 3 (Gill blood group)	Homo sapiens	42-46
28776779-8	2017	This study spotlights the overall importance of three key aspects for AQP3 inhibition: 1) water speciation of the AuIII complex, 2) stability of non-covalent adducts and 3) conformational changes induced within the pore by the coordinative binding of AuIII .	Water	90-95	aquaporin 3 (Gill blood group)	Homo sapiens	70-74
28732858-3	2017	The optimal extraction conditions with a yield of 2.84+-0.09% for extraction of polysaccharides (STP-1) were extraction time 23min, microwave power 547W, extraction temperature 80 C, and the ratio of raw material to water 1:27g/mL.	Water	216-221	transition protein 1	Homo sapiens	97-102
28585223-3	2017	However, water-soluble alpha-synuclein oligomers may be the actual culprits causing neuronal dysfunction and degeneration in synucleinopathies.	Water	9-14	synuclein, alpha	Mus musculus	23-38
29441880-9	2017	We concluded that, in the absence of a guest, solvent channels are lost during transformation to the monoclinic crystal system and space group P21/c (Form I) so that water cannot enter after desolvation.	Water	166-171	H3 histone pseudogene 16	Homo sapiens	143-148
28862871-4	2017	We find the dissociation constant for SiONa to be larger than the SiOH dissociation constant, and with knowledge of the surface energy for CCl4 in contact with H2O, we are able to determine the surface energies of the SiOH-water, SiONa-water, and CCl4-SiOX interfaces.	Water	160-163	C-C motif chemokine ligand 4	Homo sapiens	139-143
28862871-4	2017	We find the dissociation constant for SiONa to be larger than the SiOH dissociation constant, and with knowledge of the surface energy for CCl4 in contact with H2O, we are able to determine the surface energies of the SiOH-water, SiONa-water, and CCl4-SiOX interfaces.	Water	160-163	C-C motif chemokine ligand 4	Homo sapiens	247-251
28862871-4	2017	We find the dissociation constant for SiONa to be larger than the SiOH dissociation constant, and with knowledge of the surface energy for CCl4 in contact with H2O, we are able to determine the surface energies of the SiOH-water, SiONa-water, and CCl4-SiOX interfaces.	Water	223-228	C-C motif chemokine ligand 4	Homo sapiens	139-143
28862871-4	2017	We find the dissociation constant for SiONa to be larger than the SiOH dissociation constant, and with knowledge of the surface energy for CCl4 in contact with H2O, we are able to determine the surface energies of the SiOH-water, SiONa-water, and CCl4-SiOX interfaces.	Water	223-228	C-C motif chemokine ligand 4	Homo sapiens	247-251
28862871-4	2017	We find the dissociation constant for SiONa to be larger than the SiOH dissociation constant, and with knowledge of the surface energy for CCl4 in contact with H2O, we are able to determine the surface energies of the SiOH-water, SiONa-water, and CCl4-SiOX interfaces.	Water	236-241	C-C motif chemokine ligand 4	Homo sapiens	139-143
28931427-5	2017	Furthermore, 5-HT6 antagonist was applied to confirm its roles in cognition using the Morris water maze test, Y maze, and fear conditioning.	Water	93-98	5-hydroxytryptamine (serotonin) receptor 6	Mus musculus	13-18
28931427-10	2017	Furthermore, in the water maze test, Y maze, and fear conditioning test, 5-HT6 antagonist SB271046 recovered the cognitive impairment of APP/PS1 mice.	Water	20-25	5-hydroxytryptamine (serotonin) receptor 6	Mus musculus	73-78
28845969-2	2017	Every gram of HH NWs are capable of treating 20 mL emulsion (water content: 10.00 mg mL-1) with a separation efficiency of 99.23% at room temperature, and this efficiency can be further improved by tuning the surface charge density of HH.	Water	61-66	L1 cell adhesion molecule	Mus musculus	85-89
28845969-6	2017	Further economic evaluation finds that purification of every cubic meters of emulsion (water content: 10.00 mg mL-1) will cost about $34.18 for HH NWs, much lower than the $490.78 for the previously reported HH NPs, and $11 052.05-$23 420.32 Fe3O4 NP-based adsorbents, respectively.	Water	87-92	L1 cell adhesion molecule	Mus musculus	111-115
28925966-6	2017	The equilibrium Cd2+ concentration was &lt;5 mug/L, which meets the requirements of "Standards for Irrigation Water Quality" (GB5084-2005) (10 mug/L) and MCL and MCLG for groundwater and drinking water (5 mug/L) set by United States Environmental Protection Agency.	Water	177-182	CD2 molecule	Homo sapiens	16-19
28927409-3	2017	RESULTS: The biosurfactants produced by L. jensenii P6A and L. gasseri P65 reduced the water surface tension from 72 to 43.2 mN m-1 and 42.5 mN m-1 as their concentration increased up to the critical micelle concentration (CMC) values of 7.1 and 8.58 mg mL-1, respectively.	Water	87-92	L1 cell adhesion molecule	Mus musculus	254-258
28894278-3	2017	This study was conducted to investigate the effect of A. houstonianum ethanolnolic extract (AHE) on the expression of aquaporin-3 (AQP3), an integral membrane protein for water and glycerol transport in keratinocytes, and to identify the structure of the A. houstonianum bioactive compound.	Water	171-176	aquaporin 3 (Gill blood group)	Homo sapiens	131-135
28792729-0	2017	Ni3S2 Nanosheet Flowers Decorated with CdS Quantum Dots as a Highly Active Electrocatalysis Electrode for Synergistic Water Splitting.	Water	118-123	CDP-diacylglycerol synthase 1	Homo sapiens	39-42
28878011-3	2017	The device, named MasSpec Pen, enables controlled and automated delivery of a discrete water droplet to a tissue surface for efficient extraction of biomolecules.	Water	87-92	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	26-29
28633832-5	2017	SDS-PAGE and LC-ESI-MS/MS analysis suggested that PUS induced moderate oxidation of myosin causing polymerization, which may contribute to increased water retention.	Water	149-154	myosin heavy chain 14	Homo sapiens	84-90
28820214-12	2017	The design, testing and successful optimisation of the operation of the biphasic electrolysis cell under dark conditions with Cp2*Fe(II) lays the foundation for the achievement of photo-induced biphasic water electrolysis at low overpotentials using another metallocene, decamethylrutheneocene (Cp2*Ru(II)).	Water	203-208	ceruloplasmin	Homo sapiens	126-129
28837642-5	2017	Experiments confirm the predictions that 6-hydroxydopamine potently inhibits RecA and that PDF inhibition quantitatively tracks the water-mediated binding predictions.	Water	132-137	peptide deformylase, mitochondrial	Homo sapiens	91-94
28676452-0	2017	Water-extracted tubers of Cyperus rotundus L. enhance endometrial receptivity through leukemia inhibitory factor-mediated expression of integrin alphaVbeta3 and alphaVbeta5.	Water	0-5	LIF interleukin 6 family cytokine	Homo sapiens	86-112
28676452-3	2017	AIM OF STUDY: The aim of this study was to evaluate the effect of water-extracted CR on endometrial receptivity by investigating the expression of leukemia inhibitory factor (LIF) and integrins, cell adhesion, and embryo implantation using mifepristone (RU486; RU)-induced implantation failure model.	Water	66-71	LIF interleukin 6 family cytokine	Homo sapiens	175-178
28793929-2	2017	One proposed remediation strategy for coastal dead zones in the Baltic Sea is to mix the water column using pump stations, circulating oxygenated water to the sea bottom.	Water	89-94	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	71-74
28793929-2	2017	One proposed remediation strategy for coastal dead zones in the Baltic Sea is to mix the water column using pump stations, circulating oxygenated water to the sea bottom.	Water	146-151	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	71-74
28730203-3	2017	Therefore, an optimised photocatalyst APO/LCO (20 wt%) is selected for the present study and we investigate the effect of a mixed solvent system (H2O:THF) on the morphology, which has a direct effect on the photocatalytic performance.	Water	146-149	aminopeptidase O (putative)	Homo sapiens	38-41
28730203-8	2017	Excellent photocatalytic activity was observed for the APO/LCO-2 (H2O : THF = 60 : 40) sample.	Water	66-69	aminopeptidase O (putative)	Homo sapiens	55-58
28624352-5	2017	Our results enlighten the different reversible nature of alpha-synuclein fibrils fragmentation at high pressure and suggest water excluded volumes presence in the fibrils core.	Water	124-129	synuclein alpha	Homo sapiens	57-72
28587991-1	2017	The influence of controlled water deficit on the phenolic composition and gene expression of VvLAR2, VvMYBPA1, VvMYBPA2 and VvMYB4a in Cabernet Sauvignon grape skins throughout ripening was investigated.	Water	28-33	MYBPA1 protein	Vitis vinifera	101-109
28587991-1	2017	The influence of controlled water deficit on the phenolic composition and gene expression of VvLAR2, VvMYBPA1, VvMYBPA2 and VvMYB4a in Cabernet Sauvignon grape skins throughout ripening was investigated.	Water	28-33	flavonoid-related R2R3 MYB 4a repressor transcription factor	Vitis vinifera	124-131
28463586-3	2017	The mixing of river and sea water is accompanied by the sedimentation of predominantly goethite, hydromuscovite, and hydroxylapatite.	Water	28-33	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	24-27
28658952-1	2017	This paper describes the role of tetraalkylammonium counterions [NR4+, R = -CH3, -CH2CH3, -(CH2)2CH3, or -(CH2)3CH3] in gating the electrostatic potential at the interface between the 6-mercaptohexanoate (MHA) ligand shell of a PbS quantum dot (QD) and water.	Water	253-258	interleukin 13 receptor subunit alpha 1	Homo sapiens	65-68
28740238-3	2017	In our study, we found higher skin pathology scores and more serum IgE antibodies and trans-epidermal water loss in Nfkbiz -/- than in Nfkbiz-sufficient (Nfkbiz +/-) mice.	Water	102-107	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta	Mus musculus	116-122
28510292-4	2017	As a result, the optimized Cd/CdO/CdS heterojunction photoanode showed outstanding and long-term photoelectrochemical activity for water splitting, with a current density of 3.52 mA cm-2 , or a benchmark specific hydrogen production rate of 1.65 mumol cm-2  min-1 at -0.3 V versus Ag/AgCl, by using the environmental pollutants of sulfide and sulfite as sacrificial agents.	Water	131-136	CDP-diacylglycerol synthase 1	Homo sapiens	34-37
28616938-1	2017	An all-solid-state Bi2WO6/Au/CdS Z-scheme system was constructed for the photocatalytic reduction of CO2 into methane in the presence of water vapor.	Water	137-142	CDP-diacylglycerol synthase 1	Homo sapiens	29-32
28298358-1	2017	The gene encoding the aquaporin-2 water channel is regulated transcriptionally in response to vasopressin.	Water	34-39	aquaporin 2	Rattus norvegicus	22-33
28701874-13	2017	This study proposes that HSA may enhance (20S) G-Rh2 water solubility, and thus might be used as nanoparticles in the (20S) G-Rh2 delivery process.	Water	53-58	Rh associated glycoprotein	Homo sapiens	49-52
28505439-1	2017	This work focuses on the occurrence of 236U in seawater along Danish coasts, which is the sole water-exchange region between the North Sea-Atlantic Ocean and the Baltic Sea.	Water	50-55	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	135-138
28505439-1	2017	This work focuses on the occurrence of 236U in seawater along Danish coasts, which is the sole water-exchange region between the North Sea-Atlantic Ocean and the Baltic Sea.	Water	50-55	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	169-172
28505439-8	2017	While this feature might be interpreted as a clue for another significant 236U input in the Baltic Sea, it may also be caused by the complexity of water currents or slow turnover rate.	Water	147-152	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	99-102
28510419-9	2017	The fast release of Cd2+ from the pigment was further confirmed in river water under natural sunlight, with 38.6 +- 0.1% of the cadmium released within 4 h. Overall, this study underscores the importance to account for photochemical effects to inform risk assessments and regulations of cadmium pigments which are currently based on their low solubility.	Water	73-78	CD2 molecule	Homo sapiens	20-23
28580468-2	2017	In this present study, we systematically investigated the fundamental electronic properties of GaS1-xTex monolayers (x = 0, 0.125, 0.25, 0.5, 0.75, 0.875, and 1) for water splitting based on density functional theory (DFT) using the HSE06 functional.	Water	166-171	growth arrest specific 1	Homo sapiens	95-99
28540970-3	2017	In this work, a water-ethanol solution spin coating approach has been applied to directly deposit CZTS nanocrystallites on rutile TiO2 nanorods grown on an FTO substrate (TNR) for evaluation in a sensitized solar cell configuration.	Water	16-21	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	156-159
28624121-2	2017	In the present study, we hypothesize that leptin is also present in various organs of the fresh water prawns, Macrobrachium rosenbergii.	Water	96-101	leptin	Homo sapiens	42-48
28370165-3	2017	The purpose of present work was to develop a novel water soluble PARP-1 inhibitor (JPI-289) and explore its neuroprotective effect on ischaemic injury in an in vitro model.	Water	51-56	poly (ADP-ribose) polymerase 1	Rattus norvegicus	65-71
28732436-11	2017	AQP3, which involves in skin hydration and wound healing through water and glycerol transmission, is downregulated in SSc fibroblasts.	Water	65-70	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
28432819-4	2017	In the present study, the bioactive compounds in water-extract of Shaoyao-Gancao decoction were separated by the immobilized beta2 -adrenoceptor affinity column and identified using quadrupole time-of-flight mass spectrometry.	Water	49-54	adrenoceptor beta 2	Rattus norvegicus	125-144
28432819-7	2017	We identified the bioactive compounds in the water extract of Shaoyao-Gancao decoction that bound to the beta2 -adrenoceptor as paeoniflorin and liquiritin.	Water	45-50	adrenoceptor beta 2	Rattus norvegicus	105-124
28584574-0	2017	Increased glucose metabolism and alpha-glucosidase inhibition in Cordyceps militaris water extract-treated HepG2 cells.	Water	85-90	sucrase-isomaltase	Homo sapiens	33-50
28379001-3	2017	The addition of dispersion to the EFP1 potential yields improved geometries for water clusters that contain 2-6 molecules.	Water	80-85	thioredoxin domain containing 11	Homo sapiens	34-38
28440370-6	2017	The present accurate ab initio molecular dynamics simulation of liquid water was made possible by using a fragment-based second-order Moller-Plesset perturbation theory (MP2) with a large basis set to treat a large body of water molecules.	Water	71-76	tryptase pseudogene 1	Homo sapiens	170-173
28440370-6	2017	The present accurate ab initio molecular dynamics simulation of liquid water was made possible by using a fragment-based second-order Moller-Plesset perturbation theory (MP2) with a large basis set to treat a large body of water molecules.	Water	223-228	tryptase pseudogene 1	Homo sapiens	170-173
28256205-2	2017	Water and sediment quality assessment for naturally or anthropogenic radionuclides at Oman Sea as a main strategic golf for trade and transit, is an important issue.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	91-94
28267495-2	2017	The investigation aimed to prepare soy hull hemicelluloses-soy protein isolate (SHH-SPI) conjugates by Maillard reaction in a controlled dry state condition and assess the suitability of the conjugates in stabilizing oil-in-water (O/W) emulsion.	Water	224-229	sonic hedgehog signaling molecule	Homo sapiens	80-83
28189897-7	2017	This method enables the detection of Cd2+ through the Cd concentration-dependent formation of fluorescent CdNCs in tap, fountain, and pond water samples with detection limits of 0.75, 7.65, and 48.2 fM, respectively.	Water	139-144	CD2 molecule	Homo sapiens	37-40
26994044-4	2017	Yet transporter-mediated ion and water fluxes could be paralleled by water entry through additional pathways such as large-pore pannexin-1 channels opened by spreading depolarization.	Water	33-38	pannexin 1	Mus musculus	128-138
26994044-4	2017	Yet transporter-mediated ion and water fluxes could be paralleled by water entry through additional pathways such as large-pore pannexin-1 channels opened by spreading depolarization.	Water	69-74	pannexin 1	Mus musculus	128-138
28220278-3	2017	The probe RD-1 was preliminarily applied to the determination of Cd2+ ion in water samples from river and tap water with satisfying results.	Water	77-82	CD2 molecule	Homo sapiens	65-68
28220278-3	2017	The probe RD-1 was preliminarily applied to the determination of Cd2+ ion in water samples from river and tap water with satisfying results.	Water	110-115	CD2 molecule	Homo sapiens	65-68
28273345-12	2017	RESULTS: The subtracted gradients show peaks at 9.4 and 8.6 cm in water-gel and tissue-gel respectively for both pristine and SOBP beams.	Water	66-71	sine oculis binding protein homolog	Homo sapiens	126-130
28507890-3	2017	The objective of this study was to evaluate the effect of hand washing with soap and water, sanitation and hygiene (WASH) educational Intervention on the incidence of under-five children diarrhoea.	Water	85-90	WASP family homolog 6, pseudogene	Homo sapiens	116-120
28400517-4	2017	Here, we provide detailed structural mechanisms for aggregation of several protein fragments encoded by HTT exon 1 by using the associative memory, water-mediated, structure and energy model (AWSEM) to construct their free energy landscapes.	Water	148-153	huntingtin	Mus musculus	104-107
28261892-2	2017	Herein, self-supported CoP nanorod arrays have been facilely synthesized using hydrothemally deposited Co(CO3 )0.5 (OH) 0.11 H2 O nanorod arrays as the precursor, through a gas-phase phosphidation method.	Water	125-129	caspase recruitment domain family member 16	Homo sapiens	23-26
2642194-3	1989	The MEP contents accumulated in the eggs were reduced to 2-19% after they were transferred to dechlorinated tap water for 96 h. There was a significant correlation between the MEP concentration in the water and the MEP content in the eggs.	Water	112-117	neurolysin	Homo sapiens	4-7
2642194-3	1989	The MEP contents accumulated in the eggs were reduced to 2-19% after they were transferred to dechlorinated tap water for 96 h. There was a significant correlation between the MEP concentration in the water and the MEP content in the eggs.	Water	112-117	neurolysin	Homo sapiens	176-179
2642194-3	1989	The MEP contents accumulated in the eggs were reduced to 2-19% after they were transferred to dechlorinated tap water for 96 h. There was a significant correlation between the MEP concentration in the water and the MEP content in the eggs.	Water	112-117	neurolysin	Homo sapiens	176-179
2642194-5	1989	This experiment clarified that increases of MEP in Oryzias eggs were greatly affected by the MEP concentration in the water, and that the hatching rate was reduced and abnormal fry increased, even though the eggs contained the MEP only temporarily.	Water	118-123	neurolysin	Homo sapiens	44-47
2642194-5	1989	This experiment clarified that increases of MEP in Oryzias eggs were greatly affected by the MEP concentration in the water, and that the hatching rate was reduced and abnormal fry increased, even though the eggs contained the MEP only temporarily.	Water	118-123	neurolysin	Homo sapiens	93-96
2642194-5	1989	This experiment clarified that increases of MEP in Oryzias eggs were greatly affected by the MEP concentration in the water, and that the hatching rate was reduced and abnormal fry increased, even though the eggs contained the MEP only temporarily.	Water	118-123	neurolysin	Homo sapiens	93-96
2515665-5	1989	Water-soluble metabolites comprise 78% of the total products with cytochrome P-450 LM2, but only 50% of those formed by LM4.	Water	0-5	cytochrome P450 2B4	Oryctolagus cuniculus	66-86
2585511-5	1989	Our results indicate also that the hydrogen-bonded dimer is 2.2 kcal/mol more stable in water than it is in CCl4.	Water	88-93	C-C motif chemokine ligand 4	Homo sapiens	108-112
2810359-3	1989	Rapid molecular reorientation (tau c-1 greater than 10(5) s-1) reduces the magnitude of the quadrupole coupling from its static value (216 kHz for solid water).	Water	153-158	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	35-38
2752019-7	1989	Bile salts such as sodium taurocholate which are non-essential activators for the milk lipase activity on water-soluble substrates decrease the Km as well as the enzyme inhibitor dissociation constant (Ki).	Water	106-111	carboxyl ester lipase	Homo sapiens	82-93
28425995-2	2017	Numerical models of the Antarctic Ice Sheet that incorporate meltwater"s impact on ice shelves, but ignore the movement of water across the ice surface, predict a metre of global sea-level rise this century in response to atmospheric warming.	Water	65-70	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	179-182
28350432-1	2017	We demonstrate the successful functionalization of a porous aromatic framework for uranium extraction from water as exemplified by grafting PAF-1 with the uranyl chelating amidoxime group.	Water	107-112	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	140-145
28121391-4	2017	When assessed as a photocatalyst for water splitting, the CdS/WS2 -MoS2 nanostructures exhibited remarkable photocatalytic hydrogen-evolution performance and impressive durability.	Water	37-42	CDP-diacylglycerol synthase 1	Homo sapiens	58-61
28188690-0	2017	Interconnected Network of Core-Shell CoP@CoBiPi for Efficient Water Oxidation Electrocatalysis under Near Neutral Conditions.	Water	62-67	caspase recruitment domain family member 16	Homo sapiens	37-40
28188690-3	2017	This 3 D CoP@CoBiPi exhibits high catalytic activity for water oxidation at pH 9.2 and needs an overpotential (eta) of only 410 mV to drive a geometrical catalytic current density of 10 mA cm-2 , with a high turnover frequency of 819 h-1 at an overpotential of 610 mV.	Water	57-62	caspase recruitment domain family member 16	Homo sapiens	9-12
28369101-8	2017	AGI risk among ACS participants was directly related to increasing number of mouthfuls of water swallowed.	Water	90-95	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	15-18
28100478-2	2017	Central administration of adropin has been shown to inhibit water intake in rats; however, the site at which central adropin acts has yet to be elucidated.	Water	60-65	energy homeostasis associated	Rattus norvegicus	26-33
28275983-1	2017	We studied changes in sea water pH, temperature and salinity with focus on two depth layers, along the Gulf of Finland (the Baltic Sea) using long-term monitoring data from 1979 to 2015.	Water	26-31	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	22-25
29624241-0	2017	POTENTIOMETRIC STUDY OF Pd(II) COMPLEXES OF SOME FLAVONOIDS IN WATER-METHANOL-1,4-DIOXANE-ACETONITRILE (MDM) MIXTURE.	Water	63-68	secreted LY6/PLAUR domain containing 1	Homo sapiens	104-107
29624241-1	2017	The potentiometric method was used to determine the protonation (dissociation) constants for morin, rutin and chrysin and the composition and formation constants of the Pd(II)-flavonoid complexes in the water/methanol/acetonitrile/1,4-dioxane mixture (water/MDM).	Water	203-208	secreted LY6/PLAUR domain containing 1	Homo sapiens	258-261
29624241-5	2017	Obtained results provide evidence to show that investigated flavonoids in water-MDM solutions form with Pd(II) complexes of composition ML and MI..	Water	74-79	secreted LY6/PLAUR domain containing 1	Homo sapiens	80-83
28027983-10	2017	The present study indicated that Pv-C8alpha and Pv-C8beta exhibited important immune responses to infection and that ammonia-N in water decreased the immune responses of Pv-C8alpha and Pv-C8beta.	Water	130-135	complement component C8 alpha chain	Oncorhynchus mykiss	173-180
27667482-0	2017	Modeling oblong proteins and water-mediated interfaces with RosettaDock in CAPRI rounds 28-35.	Water	29-34	RAS p21 protein activator 4	Homo sapiens	75-80
27802576-0	2017	Performance of MDockPP in CAPRI rounds 28-29 and 31-35 including the prediction of water-mediated interactions.	Water	83-88	RAS p21 protein activator 4	Homo sapiens	26-31
27802576-3	2017	During the recent CAPRI rounds, a novel parallel searching strategy for predicting water-mediated interactions is introduced into our protein-protein docking method, MDockPP.	Water	83-88	RAS p21 protein activator 4	Homo sapiens	18-23
27802576-11	2017	Regarding the two targets for the prediction of water-mediated interactions, we achieved models ranked as "excellent" in accordance with the CAPRI evaluation criteria; one of these two targets is considered as a difficult target for structural water prediction.	Water	48-53	RAS p21 protein activator 4	Homo sapiens	141-146
28026062-9	2017	Our docking method also made correct predictions on other CAPRI challenges such as protein-peptide binding for 6 out of 8 targets and water predictions for 2 out of 2 targets.	Water	134-139	RAS p21 protein activator 4	Homo sapiens	58-63
27780950-6	2017	We investigated the ability of nanoparticle hydrogen in water to suppress hydroxyurea-induced ROS production, cytotoxicity, and the accumulation of beta-galactosidase (an indicator of aging), and promote cell proliferation.	Water	56-61	galactosidase, beta 1	Mus musculus	148-166
28088573-3	2017	Many potential inhibitors of hsp90 have been tested for cancer therapy but their usefulness is limited by their poor solubility in water and their ability to reach the target cells and the correct intracellular compartment.	Water	131-136	heat shock protein 90 alpha family class A member 1	Homo sapiens	29-34
28240223-6	2017	Water withdrawal for irrigation farming in the middle reaches of rivers likely caused water shortage downstream and eventually the widespread deterioration of desert oases a long time before man initiated the Aral Sea disaster in the 1960s.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	214-217
27992673-6	2017	Steady-state and time-resolved (absorption and emission) studies performed on COP suspended in 6:4 DMF/H2 O have provided valuable information about the COP species generated under different pH conditions.	Water	103-107	caspase recruitment domain family member 16	Homo sapiens	78-81
27992673-6	2017	Steady-state and time-resolved (absorption and emission) studies performed on COP suspended in 6:4 DMF/H2 O have provided valuable information about the COP species generated under different pH conditions.	Water	103-107	caspase recruitment domain family member 16	Homo sapiens	153-156
28159869-4	2017	To probe this, we used oil-drop tensiometry to characterize binding of six apoC-III variants to lipid/water interfaces.	Water	102-107	apolipoprotein C3	Homo sapiens	75-83
28159869-6	2017	ApoC-III adsorption increased surface pressure by upward of 18 mN/m at phospholipid/TG/water interfaces.	Water	87-92	apolipoprotein C3	Homo sapiens	0-8
28279707-2	2017	We have previously shown that a water extract from the plant (CAW) is neuroprotective against the deleterious cognitive effects of amyloid-beta (Abeta) exposure in a mouse model of Alzheimer"s disease, and improves learning and memory in healthy aged mice as well.	Water	32-37	amyloid beta (A4) precursor protein	Mus musculus	145-150
28296403-4	2017	The loss of this water-mediated contact blunted the osmotic sensitivity of PU.1/DNA binding, but did not alter binding under normo-osmotic conditions, suggesting that PU.1 has evolved to maximize osmotic sensitivity.	Water	17-22	Spi-1 proto-oncogene	Homo sapiens	75-79
28296403-4	2017	The loss of this water-mediated contact blunted the osmotic sensitivity of PU.1/DNA binding, but did not alter binding under normo-osmotic conditions, suggesting that PU.1 has evolved to maximize osmotic sensitivity.	Water	17-22	Spi-1 proto-oncogene	Homo sapiens	167-171
28296403-6	2017	Molecular dynamics simulations of wildtype and mutant PU.1 and Ets-1 in their free and DNA-bound states, which recapitulated experimental features of the proteins, showed that abrogation of this tyrosine-mediated water contact perturbed the Ets-1/DNA complex not through disruption of interfacial hydration, but by inhibiting local dynamics induced specifically in the bound state.	Water	213-218	Spi-1 proto-oncogene	Homo sapiens	54-58
28296403-6	2017	Molecular dynamics simulations of wildtype and mutant PU.1 and Ets-1 in their free and DNA-bound states, which recapitulated experimental features of the proteins, showed that abrogation of this tyrosine-mediated water contact perturbed the Ets-1/DNA complex not through disruption of interfacial hydration, but by inhibiting local dynamics induced specifically in the bound state.	Water	213-218	ETS proto-oncogene 1, transcription factor	Homo sapiens	63-68
28296403-6	2017	Molecular dynamics simulations of wildtype and mutant PU.1 and Ets-1 in their free and DNA-bound states, which recapitulated experimental features of the proteins, showed that abrogation of this tyrosine-mediated water contact perturbed the Ets-1/DNA complex not through disruption of interfacial hydration, but by inhibiting local dynamics induced specifically in the bound state.	Water	213-218	ETS proto-oncogene 1, transcription factor	Homo sapiens	241-246
28349153-0	2017	Al-Doped CoP nanoarray: a durable water-splitting electrocatalyst with superhigh activity.	Water	34-39	caspase recruitment domain family member 16	Homo sapiens	9-12
28349153-5	2017	Notably, this Al-CoP/CC is also superior in activity and durability as a bifunctional catalyst for alkaline water electrolysis, and its two-electrode water electrolyser delivers 10 mA cm-2 water-splitting current at a cell voltage of 1.56 V in 1.0 M KOH.	Water	108-113	caspase recruitment domain family member 16	Homo sapiens	17-20
28349153-5	2017	Notably, this Al-CoP/CC is also superior in activity and durability as a bifunctional catalyst for alkaline water electrolysis, and its two-electrode water electrolyser delivers 10 mA cm-2 water-splitting current at a cell voltage of 1.56 V in 1.0 M KOH.	Water	150-155	caspase recruitment domain family member 16	Homo sapiens	17-20
28349153-5	2017	Notably, this Al-CoP/CC is also superior in activity and durability as a bifunctional catalyst for alkaline water electrolysis, and its two-electrode water electrolyser delivers 10 mA cm-2 water-splitting current at a cell voltage of 1.56 V in 1.0 M KOH.	Water	150-155	caspase recruitment domain family member 16	Homo sapiens	17-20
28320964-4	2017	For stimuli that photoactivated one rhodopsin per Galphat the rod OS swelling response reached a saturated elongation of 10.0 +- 2.1%, at a maximum rate of 0.11% s-1 Analyzing swelling as osmotically driven water influx, we find the H2O membrane permeability of the rod OS to be (2.6 +- 0.4) x 10-5 cm s-1, comparable to that of other cells lacking aquaporin expression.	Water	207-212	rhodopsin	Mus musculus	36-45
28320964-4	2017	For stimuli that photoactivated one rhodopsin per Galphat the rod OS swelling response reached a saturated elongation of 10.0 +- 2.1%, at a maximum rate of 0.11% s-1 Analyzing swelling as osmotically driven water influx, we find the H2O membrane permeability of the rod OS to be (2.6 +- 0.4) x 10-5 cm s-1, comparable to that of other cells lacking aquaporin expression.	Water	233-236	rhodopsin	Mus musculus	36-45
28052875-3	2017	Here we provide evidence that LXRbeta regulates water homeostasis through increasing aquaporin 2 (AQP2) protein levels in renal collecting ducts.	Water	48-53	nuclear receptor subfamily 1, group H, member 2	Mus musculus	30-37
28052875-3	2017	Here we provide evidence that LXRbeta regulates water homeostasis through increasing aquaporin 2 (AQP2) protein levels in renal collecting ducts.	Water	48-53	aquaporin 2	Mus musculus	85-96
28052875-3	2017	Here we provide evidence that LXRbeta regulates water homeostasis through increasing aquaporin 2 (AQP2) protein levels in renal collecting ducts.	Water	48-53	aquaporin 2	Mus musculus	98-102
28052875-10	2017	As such, LXRbeta represents a key regulator of body water homeostasis.	Water	52-57	nuclear receptor subfamily 1, group H, member 2	Mus musculus	9-16
28553513-4	2017	1 was water-soluble, cell-membrane-permeable, had low cytotoxicity and high selectivity and sensitivity for H2S.	Water	6-11	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	108-111
28134709-6	2017	Mutations in the AVPR2 or AQP2 genes, encoding the vasopressin V2 receptor and the water channel Aquaporin2, respectively, lead to a "pure" NDI with loss of water but normal conservation of ions.	Water	83-88	aquaporin 2	Homo sapiens	26-30
28134709-6	2017	Mutations in the AVPR2 or AQP2 genes, encoding the vasopressin V2 receptor and the water channel Aquaporin2, respectively, lead to a "pure" NDI with loss of water but normal conservation of ions.	Water	83-88	aquaporin 2	Homo sapiens	97-107
28134709-6	2017	Mutations in the AVPR2 or AQP2 genes, encoding the vasopressin V2 receptor and the water channel Aquaporin2, respectively, lead to a "pure" NDI with loss of water but normal conservation of ions.	Water	157-162	aquaporin 2	Homo sapiens	26-30
28134709-6	2017	Mutations in the AVPR2 or AQP2 genes, encoding the vasopressin V2 receptor and the water channel Aquaporin2, respectively, lead to a "pure" NDI with loss of water but normal conservation of ions.	Water	157-162	aquaporin 2	Homo sapiens	97-107
27566278-7	2017	Desorption of both 3 H2 O and 14 C-glycerine from HSC was slower in pure water than from binary mixtures, a result that is largely explained by the greater swelling of HSC in water.	Water	21-25	fucosyltransferase 1 (H blood group)	Homo sapiens	50-53
27566278-7	2017	Desorption of both 3 H2 O and 14 C-glycerine from HSC was slower in pure water than from binary mixtures, a result that is largely explained by the greater swelling of HSC in water.	Water	21-25	fucosyltransferase 1 (H blood group)	Homo sapiens	168-171
27566278-7	2017	Desorption of both 3 H2 O and 14 C-glycerine from HSC was slower in pure water than from binary mixtures, a result that is largely explained by the greater swelling of HSC in water.	Water	73-78	fucosyltransferase 1 (H blood group)	Homo sapiens	50-53
27566278-7	2017	Desorption of both 3 H2 O and 14 C-glycerine from HSC was slower in pure water than from binary mixtures, a result that is largely explained by the greater swelling of HSC in water.	Water	73-78	fucosyltransferase 1 (H blood group)	Homo sapiens	168-171
27566278-7	2017	Desorption of both 3 H2 O and 14 C-glycerine from HSC was slower in pure water than from binary mixtures, a result that is largely explained by the greater swelling of HSC in water.	Water	175-180	fucosyltransferase 1 (H blood group)	Homo sapiens	50-53
27566278-7	2017	Desorption of both 3 H2 O and 14 C-glycerine from HSC was slower in pure water than from binary mixtures, a result that is largely explained by the greater swelling of HSC in water.	Water	175-180	fucosyltransferase 1 (H blood group)	Homo sapiens	168-171
27566278-8	2017	Parametric relationships were developed for water and glycerine intradiffusivities in HSC as functions of HSC water content, and a mutual diffusion coefficient was estimated by analogy with glycerine/water binary solutions.	Water	44-49	fucosyltransferase 1 (H blood group)	Homo sapiens	86-89
27566278-9	2017	The intradiffusivity of 14 C-glycerine in HSC as inferred from sorption/desorption experiments was shown to be approximately 10-fold less than that inferred from permeation experiments, whereas the corresponding values for 3 H2 O were comparable.	Water	225-229	fucosyltransferase 1 (H blood group)	Homo sapiens	42-45
28026023-4	2017	In the current study, wild-type mice and mice with depletion of aldehyde dehydrogenase 1b1 (Aldh1b1), an enzyme which has been proposed to play an important role in acetaldehyde detoxification in the intestines, received ethanol in drinking water for 1 year.	Water	241-246	aldehyde dehydrogenase 1 family, member B1	Mus musculus	92-99
28272603-5	2017	Using the peak area at 1281 cm-1 assigned to C-N stretching, C-H wagging and ring breathing, the limit of detection was calculated in both water and human plasma to be 0.7 muM (209.55 ng mL-1) and 1.39 muM (416.12 ng mL-1), respectively.	Water	139-144	L1 cell adhesion molecule	Mus musculus	187-191
28272603-5	2017	Using the peak area at 1281 cm-1 assigned to C-N stretching, C-H wagging and ring breathing, the limit of detection was calculated in both water and human plasma to be 0.7 muM (209.55 ng mL-1) and 1.39 muM (416.12 ng mL-1), respectively.	Water	139-144	L1 cell adhesion molecule	Mus musculus	217-221
28317913-8	2017	The NCM sample using diluted nitric acid showed better performance than that using de-ionized water.	Water	94-99	CWC22 spliceosome associated protein homolog	Homo sapiens	4-7
28233855-4	2017	This phenotype is caused by defects in water reabsorption that are the result of reduced aquaporin 2 levels in the kidney.	Water	39-44	aquaporin 2	Mus musculus	89-100
29964519-5	2017	Populations of viable bacteria and total bacteria in water samples were 103-104 cells mL-1 and 104-105 cells mL-1, respectively.	Water	53-58	L1 cell adhesion molecule	Mus musculus	86-90
29964519-5	2017	Populations of viable bacteria and total bacteria in water samples were 103-104 cells mL-1 and 104-105 cells mL-1, respectively.	Water	53-58	L1 cell adhesion molecule	Mus musculus	109-113
28148750-1	2017	CO2 readily combines with H2O to form [Formula: see text] and H+ Because an increase of only 100 nM in the concentration of H+ (a decrease of 0.1 unit of pH) in blood can prove fatal, the regulated excretion of CO2 during breathing is an essential life-preserving process.	Water	26-29	complement C2	Homo sapiens	0-3
28148750-1	2017	CO2 readily combines with H2O to form [Formula: see text] and H+ Because an increase of only 100 nM in the concentration of H+ (a decrease of 0.1 unit of pH) in blood can prove fatal, the regulated excretion of CO2 during breathing is an essential life-preserving process.	Water	26-29	complement C2	Homo sapiens	211-214
28316799-1	2017	In the title cobalt(II) coordination polymer with isobutyrate ligands, {[Co{CH(CH3)2CO2}2(H2O)] H2O} n , the Co2+ ion is hexa-coordinated in a slightly distorted octa-hedral coordination environment defined by two O atoms from two bridging water mol-ecules and four O atoms from four bridging carboxyl-ate ligands.	Water	240-245	complement C2	Homo sapiens	109-112
28114731-0	2017	Mechanistic insights on DBU catalyzed beta-amination of nbs to chalcone driving by water: Multiple roles of water.	Water	83-88	nibrin	Homo sapiens	56-59
2815709-1	1989	In athletes of high skills, a 5-percent decline of the body weight over 5 days by means of restricting water, fats and carbohydrates consumption was followed by reduced activity of ceruloplasmin and lysozyme of blood serum.	Water	103-108	ceruloplasmin	Homo sapiens	181-194
28114731-0	2017	Mechanistic insights on DBU catalyzed beta-amination of nbs to chalcone driving by water: Multiple roles of water.	Water	108-113	nibrin	Homo sapiens	56-59
28215094-5	2017	Dispersed water domains were probed using high pressure small-angle neutron scattering (HP-SANS), which provided evidence for elongated reversed micelles in supercritical CO2.	Water	10-15	USH1 protein network component sans	Homo sapiens	91-95
28001341-0	2017	Graphitic C3 N4 Decorated with CoP Co-catalyst: Enhanced and Stable Photocatalytic H2 Evolution Activity from Water under Visible-light Irradiation.	Water	110-115	caspase recruitment domain family member 16	Homo sapiens	31-34
2673350-1	1989	The extrinsic 33-kDa protein (P33) was cross-linked covalently to the binding site on P33-depleted PSII preparations which is responsible for reconstitution of photosynthetic water oxidation after PSII preparations have been washed with 1 M CaCl2.	Water	175-180	inhibitor of growth family member 1	Homo sapiens	30-33
27981502-14	2017	RES-SLN gel confirmed competent suppression of ear swelling and reduction in skin water content in the BALB/c mouse model of ICD when compared to marketed gel.	Water	82-87	sarcolipin	Mus musculus	4-7
28221984-10	2017	The average MS2 level in the spent centrifugation water started at 4.0 log PFU/ml for experiments with sanitizer and the average MS2 reduction in the flume wash water was 4 log (PFU) for experiments with sanitizer, demonstrating that removals could be achieved in the water itself.	Water	50-55	MS2	Homo sapiens	12-15
32263952-4	2017	Apoferritin, a macromolecular protein, can serve as an attractive nanocage to carry HB while improving its water solubility and tumor selectivity.	Water	107-112	ferritin heavy chain 1	Homo sapiens	0-11
28221984-10	2017	The average MS2 level in the spent centrifugation water started at 4.0 log PFU/ml for experiments with sanitizer and the average MS2 reduction in the flume wash water was 4 log (PFU) for experiments with sanitizer, demonstrating that removals could be achieved in the water itself.	Water	161-166	MS2	Homo sapiens	12-15
2673350-1	1989	The extrinsic 33-kDa protein (P33) was cross-linked covalently to the binding site on P33-depleted PSII preparations which is responsible for reconstitution of photosynthetic water oxidation after PSII preparations have been washed with 1 M CaCl2.	Water	175-180	inhibitor of growth family member 1	Homo sapiens	86-89
28221984-10	2017	The average MS2 level in the spent centrifugation water started at 4.0 log PFU/ml for experiments with sanitizer and the average MS2 reduction in the flume wash water was 4 log (PFU) for experiments with sanitizer, demonstrating that removals could be achieved in the water itself.	Water	161-166	MS2	Homo sapiens	129-132
28221984-10	2017	The average MS2 level in the spent centrifugation water started at 4.0 log PFU/ml for experiments with sanitizer and the average MS2 reduction in the flume wash water was 4 log (PFU) for experiments with sanitizer, demonstrating that removals could be achieved in the water itself.	Water	161-166	MS2	Homo sapiens	12-15
28253626-1	2017	A water-soluble oxatub[4]arene with tri(ethylene oxide) moieties was synthesized.	Water	2-7	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	36-39
28221984-10	2017	The average MS2 level in the spent centrifugation water started at 4.0 log PFU/ml for experiments with sanitizer and the average MS2 reduction in the flume wash water was 4 log (PFU) for experiments with sanitizer, demonstrating that removals could be achieved in the water itself.	Water	161-166	MS2	Homo sapiens	129-132
2542252-2	1989	NPY dimerizes in aqueous solution and forms stable monolayers at the air-water interface, suggesting that these amphiphilic conformations are stabilized at interfaces.	Water	73-78	neuropeptide Y	Homo sapiens	0-3
28161785-9	2017	Graphical abstract Water mediated recognition of structural and catalytic zinc ions of hMMP-1 structure (MD simulatated conformation).	Water	19-24	matrix metallopeptidase 1	Homo sapiens	87-93
2539198-1	1989	FT-IR spectroscopy has been used to investigate the conformation of rhodopsin in bovine rod outer segment membranes, dispersed in aqueous suspension in both 2H2O and H2O.	Water	158-161	rhodopsin	Bos taurus	68-77
28054076-9	2017	Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) images of the bis-TEG amide attached dyes in lipid monolayer-coated droplets of water-in-oil reveal that the TPEF and SHG involve transition dipole moments in different orientations.	Water	156-161	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	33-37
28054076-9	2017	Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) images of the bis-TEG amide attached dyes in lipid monolayer-coated droplets of water-in-oil reveal that the TPEF and SHG involve transition dipole moments in different orientations.	Water	156-161	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	185-189
27910158-10	2017	The crude water extract, the methanol extract, and the methanol extract derived AQ fraction showed alpha-glucosidase inhibiting effects.	Water	10-15	sucrase-isomaltase	Homo sapiens	99-116
2564894-6	1989	These observations suggested that esters at C-2" and/or C-7, which would tend to promote water solubility, might serve as useful prodrugs of taxol.	Water	89-94	complement C2	Homo sapiens	44-47
28177032-2	2017	Sc(OTf)3 catalysis in the presence of water is used to synthesize anhydrides in one step from amides without external nucleophiles.	Water	38-43	POU class 5 homeobox 1	Homo sapiens	0-8
28222129-6	2017	In order to provide with the adequate water permeability to the cell membrane of Xenopus laevis oocytes, mRNA of aquaporin 1 was co-expressed with homomeric or heteromeric Slick and Slack alpha-subunits.	Water	38-43	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	113-124
27889609-1	2017	Aquaporin-2 (AQP2) is a water channel in collecting duct principal cells in the kidney.	Water	24-29	aquaporin 2	Canis lupus familiaris	0-11
27889609-1	2017	Aquaporin-2 (AQP2) is a water channel in collecting duct principal cells in the kidney.	Water	24-29	aquaporin 2	Canis lupus familiaris	13-17
2724160-3	1989	Finger portions from latex and vinyl examination gloves were sealed to syringe barrels and exposed to alcohol, eugenol, a surface disinfectant, cavity varnish, or commercial mouth wash. Tritiated water was introduced into the finger-tip portion, which was suspended in a vacuum flask containing distilled water.	Water	196-201	TOR signaling pathway regulator	Homo sapiens	233-236
28044410-1	2017	Salecan is a water-soluble bacterial polysaccharide consisting of glucopyranosyl units linked by alpha-1,3 and beta-1,3 glycosidic bonds.	Water	13-18	adrenoceptor alpha 1D	Homo sapiens	97-106
28121381-13	2017	CONCLUSIONS: XACT images with intensity related to the spatial distribution of deposited dose in a water tank were formed for a variety of field sizes and shapes.	Water	99-104	X active specific transcript	Homo sapiens	13-17
2704753-3	1989	A peptidic factor contained in the neuron R15 has been shown to increase the water content of Aplysia.	Water	77-82	ribonuclease A family member 2	Rattus norvegicus	42-45
27842964-0	2017	Hygroscopic behavior of water-soluble matter in marine aerosols over the East China Sea.	Water	24-29	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	84-87
27842819-2	2017	In the current study, we evaluated the anti-adhesive mechanisms of a water-soluble polysaccharide (BCP) extracted from Bupleurum chinense.	Water	69-74	opsin 1, short wave sensitive	Homo sapiens	99-102
27611473-9	2017	The small molecules regulated dual-functional platform based on UCNPs/AuNPs is a simple, label-free method and can be applied for the turn-on fluorescence detection of AChE activity in human serum and Cd2+ in real water samples.	Water	214-219	CD2 molecule	Homo sapiens	201-204
2704753-5	1989	The purification yielded a number of peptides, only one of which, R15 alpha 1, resulted in water uptake when injected into animals.	Water	91-96	ribonuclease A family member 2	Rattus norvegicus	66-69
28690252-1	2017	A solid-phase extraction based on a functionalized SBA-15, with the Schiff base ligand, ethylenediaminepropylesalicylaldimine (SBA/EnSA), was developed for the recovery and preconcentration of trace amounts of uranium(VI) in water samples, prior to its determination spectrophotometrically using ArsenazoIII.	Water	225-230	endosulfine alpha	Homo sapiens	131-135
27561380-4	2017	This robust, abundant, and stable photocatalyst based on covalent organic frameworks is demonstrated to hold great promise by forming heterojunctions with CoP and Pt for catalyzing the direct splitting of water into stoichiometric H2 and O2 using energy from photons.	Water	205-210	caspase recruitment domain family member 16	Homo sapiens	155-158
2786129-6	1989	Human recombinant IL-1 alpha (10(-7) to 10(-9) M) administered into the lumina of the vessels depressed pumping activity approximately 5-30% at transmural pressures between 2 and 16 cm H2O.	Water	185-188	interleukin 1 alpha	Homo sapiens	18-28
27918140-1	2017	Hyperpolarized water can selectively enhance NMR signals of rapidly exchanging protons in osteopontin (OPN), a metastasis-associated intrinsically disordered protein (IDP), at near-physiological pH and temperature.	Water	15-20	secreted phosphoprotein 1	Homo sapiens	90-101
27155578-8	2017	In a prospective work using SRCD, we also studied the evolution of the secondary structure of the myoglobin protein in water solution in the same evaporation conditions.	Water	119-124	myoglobin	Homo sapiens	98-107
27918140-1	2017	Hyperpolarized water can selectively enhance NMR signals of rapidly exchanging protons in osteopontin (OPN), a metastasis-associated intrinsically disordered protein (IDP), at near-physiological pH and temperature.	Water	15-20	secreted phosphoprotein 1	Homo sapiens	103-106
2713064-7	1989	The crude LPS antigen showed better sensitivity: 73% versus 53% of the water-phenol extracted one despite a high index correlation (r = 0.88).	Water	71-76	interferon regulatory factor 6	Homo sapiens	10-13
27784696-1	2017	Phosphorylation of the aquaporin-2 (AQP2) water channel at four COOH-terminal serines plays a central role in the regulation of water permeability of the renal collecting duct.	Water	42-47	aquaporin 2	Homo sapiens	23-34
28775901-14	2017	CONCLUSION: The study demonstrated that it is possible to recover latent prints submerged in water on different studied dry non porous surfaces with the best visualization method using cyanoacrylate either in fresh or sea water.	Water	93-98	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	218-221
27507510-1	2017	The synthesis of glucose esters with palmitic acid, lauric acid and hexanoic acid using lipase enzyme was studied and their emulsion functionality in oil-in-water system were compared.	Water	157-162	PAN0_003d1715	Moesziomyces antarcticus	88-94
27784696-1	2017	Phosphorylation of the aquaporin-2 (AQP2) water channel at four COOH-terminal serines plays a central role in the regulation of water permeability of the renal collecting duct.	Water	42-47	aquaporin 2	Homo sapiens	36-40
27784696-1	2017	Phosphorylation of the aquaporin-2 (AQP2) water channel at four COOH-terminal serines plays a central role in the regulation of water permeability of the renal collecting duct.	Water	128-133	aquaporin 2	Homo sapiens	23-34
27784696-1	2017	Phosphorylation of the aquaporin-2 (AQP2) water channel at four COOH-terminal serines plays a central role in the regulation of water permeability of the renal collecting duct.	Water	128-133	aquaporin 2	Homo sapiens	36-40
29465378-0	2017	Investigation of water-soluble elastin as a multifunctional cosmetic material: Moisturizing and whitening effects.	Water	17-22	LOC100620140	Sus scrofa	31-38
2591601-4	1989	In rats, induction of EAU but not of Experimental Autoimmune Pinealitis (EAP) could be prevented by the administration of S-antigen specific rat monoclonal antibody simultaneously with the S-antigen.	Water	22-25	S-antigen visual arrestin	Rattus norvegicus	122-131
29465378-4	2017	Water-soluble hot alkali pig aorta (HAPA)-elastin was prepared from pig aorta using the hot alkali method.	Water	0-5	LOC100620140	Sus scrofa	42-49
2540397-4	1989	We find that the number q of exchangeable water molecules coordinated directly to the Gd3+ ions tends to be smaller in the phosphonates, in principle reducing their utility in MRI.	Water	42-47	GRDX	Homo sapiens	86-89
28408792-7	2017	Treatment with a thrombopoietin receptor agonist, Alxn4100TPO, after CI improved survival, mitigated body-weight loss, and reduced water consumption.	Water	131-136	myeloproliferative leukemia virus oncogene	Mus musculus	17-40
27908549-4	2017	RESULTS: The water extracts (dose-dependently for noni leaves) increased bone regeneration biomarker (runt-related transcription factor 2, bone morphogenetic protein 2, osteoprotegerin, estrogen receptor 1 [ESR1], collagen type I alpha 1A) expressions and reduced the inflammatory biomarkers (interleukin-6, tumor necrosis factor-alpha, nuclear factor [NF]-kappaB, and receptor activator of NF-kappaB ligand) mRNA expressions/levels in the rats.	Water	13-18	TNF receptor superfamily member 11B	Rattus norvegicus	169-184
28496059-1	2017	Presented here is a simple yet rapid and efficient analytical method for visual as well as spectroscopic method for sensing of trace concentrations of Cu2+ ions in aqueous medium by systematic photoluminescence quenching of a highly water soluble probe made of CdS quantum dots surface modified by thiourea.	Water	233-238	CDP-diacylglycerol synthase 1	Homo sapiens	261-264
27793629-0	2017	Microsecond simulation of human aquaporin 2 reveals structural determinants of water permeability and selectivity.	Water	79-84	aquaporin 2	Homo sapiens	32-43
27908549-4	2017	RESULTS: The water extracts (dose-dependently for noni leaves) increased bone regeneration biomarker (runt-related transcription factor 2, bone morphogenetic protein 2, osteoprotegerin, estrogen receptor 1 [ESR1], collagen type I alpha 1A) expressions and reduced the inflammatory biomarkers (interleukin-6, tumor necrosis factor-alpha, nuclear factor [NF]-kappaB, and receptor activator of NF-kappaB ligand) mRNA expressions/levels in the rats.	Water	13-18	estrogen receptor 1	Rattus norvegicus	186-205
3226612-2	1988	To better understand the effect of AVP released by extrahypothalamic fibers in brain, we microinfused AVP into intact brain and studied its effect on brain water and electrolytes.	Water	156-161	arginine vasopressin	Felis catus	102-105
27908549-4	2017	RESULTS: The water extracts (dose-dependently for noni leaves) increased bone regeneration biomarker (runt-related transcription factor 2, bone morphogenetic protein 2, osteoprotegerin, estrogen receptor 1 [ESR1], collagen type I alpha 1A) expressions and reduced the inflammatory biomarkers (interleukin-6, tumor necrosis factor-alpha, nuclear factor [NF]-kappaB, and receptor activator of NF-kappaB ligand) mRNA expressions/levels in the rats.	Water	13-18	estrogen receptor 1	Rattus norvegicus	207-211
30187726-12	2017	Some extract appeared to be fungicidal and hot water extract were more active against Cryptococcus neoformans with the MFC value of 0.06 mg mL-1.	Water	47-52	L1 cell adhesion molecule	Mus musculus	140-144
27793629-2	2017	The present study provides detailed insights into the transport properties of AQP2 with the use of microsecond-scale molecular dynamics simulations, and explains how these channels conduct water molecules while at the same time excluding other molecules.	Water	189-194	aquaporin 2	Homo sapiens	78-82
28290315-0	2017	Inactivation modeling of human enteric virus surrogates, MS2, Qbeta, and PhiX174, in water using UVC-LEDs, a novel disinfecting system.	Water	85-90	MS2	Homo sapiens	57-60
3226612-6	1988	AVP increased water content significantly in gray and white matter sites, while electrolyte content was unchanged.	Water	14-19	arginine vasopressin	Felis catus	0-3
3049599-0	1988	Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.	Water	125-130	interleukin 2	Rattus norvegicus	86-99
28204957-8	2017	MOR and DOR activation also results in inhibition of submucosal secretomotor neurons reducing active Cl- secretion and passive water movement into the colonic lumen.	Water	127-132	opioid receptor mu 1	Homo sapiens	0-3
28027650-0	2016	Fabrication of CuFe2O4/alpha-Fe2O3 Composite Thin Films on FTO Coated Glass and 3-D Nanospike Structures for Efficient Photoelectrochemical Water Splitting.	Water	140-145	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	59-62
20539507-2	1988	Reported optical anomalies for clear ocean waters at longer wavelengths (520 nm +) are explained by the effects of water Raman emission, and the simulation results are confirmed by Biowatt-NORDA observations made in the Sargasso Sea.	Water	43-48	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	229-232
27980322-1	2016	BACKGROUND Aquaporin-2 (AQP2) plays a major role in water reabsorption in the renal collecting duct, and is involved in a variety of renal disease.	Water	52-57	aquaporin 2	Homo sapiens	11-22
27980322-1	2016	BACKGROUND Aquaporin-2 (AQP2) plays a major role in water reabsorption in the renal collecting duct, and is involved in a variety of renal disease.	Water	52-57	aquaporin 2	Homo sapiens	24-28
27973793-14	2016	Metadynamics simulation analysis of the dipeptide in water also supported the PGII-PPII-like conformation at the N- and C-terminals, respectively, as the energetically stable conformation among the other possible combinations of conformations.	Water	53-58	decorin	Homo sapiens	78-82
27662300-6	2017	The deficits in spontaneous alternation, place learning in the water-maze, and novel object recognition observed in APPSwe mice were alleviated by the low dose of Neuro-EPO.	Water	63-68	erythropoietin	Mus musculus	169-172
29465378-9	2017	The water content of skin samples treated with and without HAPA-elastin was 77.2% +- 7.8% and 49.4% +- 10.1%, respectively.	Water	4-9	LOC100620140	Sus scrofa	64-71
2973511-5	1988	Thus, in the conscious newborn calf, changes in plasma ANP levels and urinary water and sodium excretion during hypertonic saline infusion are compatible with the hypothesis that endogenous ANP participates, at least in part, in the immediate diuretic and natriuretic renal response induced by the sodium overload.	Water	78-83	natriuretic peptide A	Bos taurus	190-193
28523299-3	2017	Aquaporin 4 (AQP4) has been found to be the most important water channel in the brain, and its inhibition before inducing focal ischemia in an animal model of stroke proved to alleviate the pathology and improve clinical recovery.	Water	59-64	aquaporin 4	Rattus norvegicus	0-11
28523299-3	2017	Aquaporin 4 (AQP4) has been found to be the most important water channel in the brain, and its inhibition before inducing focal ischemia in an animal model of stroke proved to alleviate the pathology and improve clinical recovery.	Water	59-64	aquaporin 4	Rattus norvegicus	13-17
27711857-2	2016	We have used transition path sampling to generate an ensemble of reactive trajectories of the self-exchange reaction between a pair of Ru2+ and Ru3+ ions in water.	Water	157-162	doublecortin domain containing 2	Homo sapiens	135-138
27783929-3	2016	We detected and characterized in considerable detail aperiodic fluctuations in the raw water following regional precipitation, with TCC increasing up to 50-fold from a dry weather baseline of approximately 120 cells mul-1 to an event peak of &gt; 5000 cells mul-1.	Water	87-92	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	216-221
27783929-3	2016	We detected and characterized in considerable detail aperiodic fluctuations in the raw water following regional precipitation, with TCC increasing up to 50-fold from a dry weather baseline of approximately 120 cells mul-1 to an event peak of &gt; 5000 cells mul-1.	Water	87-92	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	258-263
27960411-5	2016	Water-in-oil-in-water (w/o/w) double emulsion method was used to coload antisense-miRNA-21 and GEM in PEGylated-PLGA-NPs.	Water	0-5	microRNA 21	Homo sapiens	82-90
3246690-5	1988	The tip displacement is accounted for by a model in which contrast is dominated by local fluctuations in the deformability of the adsorbate layer, a quantity deduced from measurements of the apparent barrier heights in air, water, over small molecule adsorbates, and over DNA.	Water	224-229	TOR signaling pathway regulator	Homo sapiens	4-7
27960411-5	2016	Water-in-oil-in-water (w/o/w) double emulsion method was used to coload antisense-miRNA-21 and GEM in PEGylated-PLGA-NPs.	Water	16-21	microRNA 21	Homo sapiens	82-90
2971569-1	1988	Water proton nuclear relaxation measurements are used to detect and characterize four distinct intermediate states for Gd3+ bound to Ca2+ sites of sarcoplasmic reticulum Ca2+-ATPase in complexes with ATP analogues.	Water	0-5	GRDX	Homo sapiens	119-122
27983600-1	2016	Aquaporin-5 (AQP5) is a membrane water channel widely distributed in human tissues that was found up-regulated in different tumors and considered implicated in carcinogenesis in different organs and systems.	Water	33-38	aquaporin 5	Homo sapiens	0-11
27983600-1	2016	Aquaporin-5 (AQP5) is a membrane water channel widely distributed in human tissues that was found up-regulated in different tumors and considered implicated in carcinogenesis in different organs and systems.	Water	33-38	aquaporin 5	Homo sapiens	13-17
27993063-2	2016	Here we show that Ag2SNPs can release tiny amounts of silver ion via cation exchange reactions between Ag(I) and Fe(III) in the dark, while in the light dramatic dissolution of Ag2SNP occurs, which is mainly attributed to the Ag2SNP oxidation by the hydroxyl radical formed during the reduction of Fe(III) to Fe(II) in water under sunlit conditions.	Water	319-324	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	18-21
2971569-2	1988	In the absence of nucleotides, Gd3+ binds to two occluded Ca2+ transport sites on Ca2+-ATPase which have a low accessibility to solvent water.	Water	136-141	GRDX	Homo sapiens	31-34
27565855-1	2016	Water dispersible, highly efficient nickel doped CdS nanoparticles anchored on graphene nanosheets as a photocatalyst for cephalexin and sulfamethoxazole photodegradation have been prepared in a facile microwave-furnace assisted method.	Water	0-5	CDP-diacylglycerol synthase 1	Homo sapiens	49-52
27760771-2	2016	Water reabsorption in the collecting duct principal cells is controlled by vasopressin, a peptide hormone that induces the osmotic water transport across the collecting duct epithelia through regulation of water channel proteins aquaporin-2 (AQP2) and aquaporin-3 (AQP3).	Water	0-5	aquaporin 2	Homo sapiens	229-240
27760771-2	2016	Water reabsorption in the collecting duct principal cells is controlled by vasopressin, a peptide hormone that induces the osmotic water transport across the collecting duct epithelia through regulation of water channel proteins aquaporin-2 (AQP2) and aquaporin-3 (AQP3).	Water	0-5	aquaporin 2	Homo sapiens	242-246
2900838-3	1988	In the present paper we report the characterization of a water-soluble form of Thy-1, purified from human cerebrospinal fluid (CSF).	Water	57-62	Thy-1 cell surface antigen	Homo sapiens	79-84
27760771-2	2016	Water reabsorption in the collecting duct principal cells is controlled by vasopressin, a peptide hormone that induces the osmotic water transport across the collecting duct epithelia through regulation of water channel proteins aquaporin-2 (AQP2) and aquaporin-3 (AQP3).	Water	0-5	aquaporin 3 (Gill blood group)	Homo sapiens	252-263
27760771-2	2016	Water reabsorption in the collecting duct principal cells is controlled by vasopressin, a peptide hormone that induces the osmotic water transport across the collecting duct epithelia through regulation of water channel proteins aquaporin-2 (AQP2) and aquaporin-3 (AQP3).	Water	0-5	aquaporin 3 (Gill blood group)	Homo sapiens	265-269
27760771-2	2016	Water reabsorption in the collecting duct principal cells is controlled by vasopressin, a peptide hormone that induces the osmotic water transport across the collecting duct epithelia through regulation of water channel proteins aquaporin-2 (AQP2) and aquaporin-3 (AQP3).	Water	131-136	aquaporin 2	Homo sapiens	229-240
27846987-6	2016	The new electrode was successfully applied to real water samples for simultaneous detection of Cd2+ and Pb2+ with good recovery rates.	Water	51-56	CD2 molecule	Homo sapiens	95-98
27593225-10	2016	In Wistar rats dDAVP mainly increased AQP2 expression while in Brattleboro rats it increased functional water permeability mainly by AQP3 expression.	Water	104-109	aquaporin 3 (Gill blood group)	Rattus norvegicus	133-137
27695900-3	2016	GPX1 is an important detoxification enzyme that converts H2O2 to water.	Water	65-70	glutathione peroxidase 1	Mus musculus	0-4
26671618-4	2016	Morris water-maze revealed a genotype effect on spatial learning and memory as APP/PS1-sTBI mice performed more poorly than Wt-sTBI mice (p < 0.05).	Water	7-12	presenilin 1	Mus musculus	83-86
28090588-3	2016	Thus, this study aims to establish the reproducibility of the measurement of the macromolecular-to-free water proton pool size ratio (PSR) in healthy fibroglandular (FG) breast tissue.	Water	104-109	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	134-137
27892464-2	2016	For the treatment of heritable NDI, novel strategies that bypass the defective vasopressin type 2 receptor are required to activate the aquaporin-2 (AQP2) water channel.	Water	155-160	aquaporin 2	Mus musculus	136-147
27892464-2	2016	For the treatment of heritable NDI, novel strategies that bypass the defective vasopressin type 2 receptor are required to activate the aquaporin-2 (AQP2) water channel.	Water	155-160	aquaporin 2	Mus musculus	149-153
27808289-0	2016	Importance of the structural integrity of a carbon conjugated mediator for photocatalytic hydrogen generation from water over a CdS-carbon nanotube-MoS2 composite.	Water	115-120	CDP-diacylglycerol synthase 1	Homo sapiens	128-131
27808289-1	2016	Incorporation of CdS quantum dots is shown to significantly promote photocatalytic hydrogen production from water over single-layer MoS2 in a remote manner via their dispersions on a carbon nanotube as a nanocomposite: the hydrogen evolution rate is found to be critically dependent on the content and structural integrity of the carbon nanotube such that the double-walled carbon nanotube shows superior H2 production to a single-walled carbon nanotube because the inner carbon tubules survive from the structural damage during functionalization.	Water	108-113	CDP-diacylglycerol synthase 1	Homo sapiens	17-20
27829416-5	2016	METHODS: Three different extracts (water, methanol and ethanol) from leaves, flowers and tubers of A. microcarpus were evaluated for their inhibitory effect on tyrosinase activity using L-3,4-dihydroxyphenylalanine (L-DOPA) as substrate.	Water	35-40	tyrosinase	Mus musculus	160-170
27777990-8	2016	It is found that irrespective of the Abeta peptide conformations and their nonuniform fluctuations, water molecules around the hydrophobic hp1 and hp2 segments are relatively weakly bound.	Water	100-105	chromobox 5	Homo sapiens	139-142
27777990-9	2016	This is an important observation, as in the presence of other monomers such weakly bound water molecules around hp1 and hp2 are expected to be easily displaced during the hydrophobic collapse that leads to Abeta aggregation.	Water	89-94	chromobox 5	Homo sapiens	112-115
27686614-3	2016	NHE8 is important for water/sodium absorption in the intestine, and loss of NHE8 function results in mucosal injury.	Water	22-27	solute carrier family 9 member A8	Homo sapiens	0-4
27707708-8	2016	In contrast, CD NOS3 KO male, but not female, mice had lower urine volume and higher urine osmolality over the course of 7 days of water loading compared with control mice.	Water	131-136	nitric oxide synthase 3, endothelial cell	Mus musculus	16-20
27601043-7	2016	The method precision (RSD%) with four replicate determinations was 4.9% for distilled water at the concentration level of 10 ng mL-1 The obtained RSD% for reproducibility of stir bars was 7.4%.	Water	86-91	L1 cell adhesion molecule	Mus musculus	128-132
27785978-1	2016	AIM: This work spotlights on fabrication of CD44-tropic, layer-by-layer (LbL) coated, liquid crystalline nanoparticles of rapamycin (Rap-LbL-LCNPs) to enhance its water solubility and enable its anticancer use.	Water	163-168	LDL receptor related protein associated protein 1	Homo sapiens	133-136
27718891-8	2016	Similarly, the brain water content at day 3 after HI in BCAO + EPO-treated rats was lower than BCAO-treated animals (P &lt; 0.05).	Water	21-26	erythropoietin	Rattus norvegicus	63-66
27667693-0	2016	Computational Repacking of HIF-2alpha Cavity Replaces Water-Based Stabilized Core.	Water	54-59	endothelial PAS domain protein 1	Homo sapiens	27-37
27667693-2	2016	Within the HIF-2 complex, one domain (HIF-2alpha PAS-B) contains a large (290 A3) buried cavity filled with water molecules within its hydrophobic core.	Water	108-113	endothelial PAS domain protein 1	Homo sapiens	38-48
27801846-4	2016	This mediates insertion of AQP2 into the apical plasma membrane, increasing water permeability of the collecting duct.	Water	76-81	aquaporin 2	Homo sapiens	27-31
27704861-9	2016	Here, we report a residue-specific water accessibility experiment for a small membrane protein, sarcolipin (SLN), embedded in oriented lipid bicelles as probed by new water-edited SLF (WE-SLF) experiments.	Water	167-172	sarcolipin	Homo sapiens	96-106
27704861-9	2016	Here, we report a residue-specific water accessibility experiment for a small membrane protein, sarcolipin (SLN), embedded in oriented lipid bicelles as probed by new water-edited SLF (WE-SLF) experiments.	Water	167-172	sarcolipin	Homo sapiens	108-111
27704861-10	2016	We show that SLN"s residues belonging to the juxtamembrane region are more exposed to the water-lipid interface than the corresponding membrane-embedded residues.	Water	90-95	sarcolipin	Homo sapiens	13-16
27734037-1	2016	A new rigid tritopic phosphonic ligand, 2,4,6-tris(4-phosphonophenyl)pyridine (H6L), was synthesized and used to assemble isostructural barium (1) and strontium (2) phosphonate metal organic frameworks that exhibit fully reversible and selective water-dependent fluorescence red-shift at room temperature.	Water	246-251	H6 family homeobox 2	Homo sapiens	79-82
27725713-2	2016	It occurs in part through long-term mechanisms that regulate the abundance of the aquaporin-2 water channel in renal collecting duct cells.	Water	94-99	aquaporin 2	Homo sapiens	82-93
27711538-4	2016	The Glu451-assisted water addition on amide carbon atoms and nitrogen inversion (i.e. change of pyramidalization on the leaving nitrogen) are shown to be the rate-determining steps with the activation energies in a good agreement with the experimental results for the Leu-enkephalin hydrolysis.	Water	20-25	prodynorphin	Homo sapiens	268-282
27711686-6	2016	Water molecules in CCl4 were shown to form clusters in [BMIM]I; presumably, I- anions work as nucleation centers of water clusters.	Water	0-5	C-C motif chemokine ligand 4	Homo sapiens	19-23
27711686-6	2016	Water molecules in CCl4 were shown to form clusters in [BMIM]I; presumably, I- anions work as nucleation centers of water clusters.	Water	116-121	C-C motif chemokine ligand 4	Homo sapiens	19-23
27620667-2	2016	The guanylin peptides could be related to sodium absorption inhibition and water secretion induction and their dysfunction may be related to various pathologies such as chronic renal failure, congestive heart failure and nephrotic syndrome.	Water	75-80	guanylate cyclase activator 2A	Homo sapiens	4-12
27933794-1	2016	Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-l-lysine to yield products l-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn2+ or Fe2+).	Water	157-162	histone deacetylase 8	Homo sapiens	0-21
27933794-1	2016	Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-l-lysine to yield products l-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn2+ or Fe2+).	Water	157-162	histone deacetylase 8	Homo sapiens	23-28
27299481-1	2016	A water soluble Hantzsch ester derivative of coumarin, DHPS, was synthesized and successfully applied in the fluorescent sensing nitric oxide (NO) in aqueous solution.	Water	2-7	deoxyhypusine synthase	Mus musculus	55-59
27784697-2	2016	A key mechanism involved in this process, the arginine vasopressin-mediated phosphorylation and apical membrane insertion of aquaporin 2 in the collecting duct, has been extensively studied; however, with the increased availability of conditional knockout animals, several novel collecting duct proteins have recently been implicated in water homeostasis.	Water	337-342	aquaporin 2	Homo sapiens	125-136
26429198-7	2016	These findings provide direct evidence for AQP4 and AQP5 expression in the large intestine, suggesting that different AQPs collaborate functionally and distinctively in water handling during intestinal development, especially during the first period after delivery.	Water	169-174	aquaporin 4	Bos taurus	43-47
27461974-1	2016	INTRODUCTION: Water channel aquaporin 3 (AQP3) is an aquaglyceroporin that transports small neutral solutes and water.	Water	14-19	aquaporin 3 (Gill blood group)	Homo sapiens	28-39
27461974-1	2016	INTRODUCTION: Water channel aquaporin 3 (AQP3) is an aquaglyceroporin that transports small neutral solutes and water.	Water	14-19	aquaporin 3 (Gill blood group)	Homo sapiens	41-45
27461974-1	2016	INTRODUCTION: Water channel aquaporin 3 (AQP3) is an aquaglyceroporin that transports small neutral solutes and water.	Water	112-117	aquaporin 3 (Gill blood group)	Homo sapiens	28-39
27461974-1	2016	INTRODUCTION: Water channel aquaporin 3 (AQP3) is an aquaglyceroporin that transports small neutral solutes and water.	Water	112-117	aquaporin 3 (Gill blood group)	Homo sapiens	41-45
27687077-5	2016	When the substances with the cited hazard statement codes react with water or an acid, they can release HCl, Cl2, HF, HCN, PH3, H2S, SO2 (and two other gases very unlikely to be emitted, hydrazoic acid HN3 and selenium oxide SeO2 - a solid with low vapor pressure).	Water	69-74	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	118-121
27694043-8	2016	Scanning environmental microscope analysis revealed that sludge flocs conditioned by Alb and Alc (especially PAC2.5 and Al13) exhibited obvious botryoidal structure, this is because sludge flocs formed by Alb and Alc were more compact and floc strength is high, it was easy generated plentiful tiny channels for water release.	Water	312-317	allantoicase	Homo sapiens	93-96
27694043-8	2016	Scanning environmental microscope analysis revealed that sludge flocs conditioned by Alb and Alc (especially PAC2.5 and Al13) exhibited obvious botryoidal structure, this is because sludge flocs formed by Alb and Alc were more compact and floc strength is high, it was easy generated plentiful tiny channels for water release.	Water	312-317	allantoicase	Homo sapiens	213-216
27696875-1	2016	We report the synthesis, spectroscopy, and the DNA binding properties of a biocompatible, water-soluble, polycationic two-photon absorbing anthracenyl derivative (Ant-PIm) specifically designed for biorelated applications.	Water	90-95	solute carrier family 25 member 6	Homo sapiens	163-166
27824119-6	2016	Supplementation of a TrkB agonist 7,8-dihydroxyflavone (1 mg/mL in drinking water) during juvenile and adolescent stages could prevent these behavioral abnormalities, reduced BDNF-TrkB signaling in PFC and CA1, and immunoreactivity of PV and PGC-1alpha in the PrL of medial PFC and CA1 in the adult offspring from poly(I:C)-treated mice.	Water	76-81	brain derived neurotrophic factor	Mus musculus	175-179
27834794-5	2016	The MR S-phone-based AuNPs-aptamer colorimetric sensor system could reliably detect Hg2+ in both tap water and Pearl River water samples and produced a linear colorimetric readout of Hg2+ concentration in the range of 1 ng/mL-32 ng/mL with a correlation of 0.991, and a limit of detection (LOD) of 0.28 ng/mL for Hg2+.	Water	101-106	sterile alpha motif domain containing 11	Homo sapiens	4-8
27834794-5	2016	The MR S-phone-based AuNPs-aptamer colorimetric sensor system could reliably detect Hg2+ in both tap water and Pearl River water samples and produced a linear colorimetric readout of Hg2+ concentration in the range of 1 ng/mL-32 ng/mL with a correlation of 0.991, and a limit of detection (LOD) of 0.28 ng/mL for Hg2+.	Water	123-128	sterile alpha motif domain containing 11	Homo sapiens	4-8
27684197-1	2016	Porous PLGA microparticle for the coencapsulation of doxorubicin and miR-519c was successfully constructed through the water-oil-water emulsion solvent evaporation method, using ammonium bicarbonate as a porogen.	Water	119-124	microRNA 519c	Homo sapiens	69-77
27684197-1	2016	Porous PLGA microparticle for the coencapsulation of doxorubicin and miR-519c was successfully constructed through the water-oil-water emulsion solvent evaporation method, using ammonium bicarbonate as a porogen.	Water	129-134	microRNA 519c	Homo sapiens	69-77
32801383-0	2016	Greenhouse Gas Emissions from Reservoir Water Surfaces: A New Global Synthesis.	Water	40-45	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	11-14
27460199-0	2016	The role of known variants of KCNQ1, KCNH2, KCNE1, SCN5A, and NOS1AP in water-related deaths.	Water	72-77	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	30-35
27460199-0	2016	The role of known variants of KCNQ1, KCNH2, KCNE1, SCN5A, and NOS1AP in water-related deaths.	Water	72-77	nitric oxide synthase 1 adaptor protein	Homo sapiens	62-68
27460199-8	2016	These results propose that performing a molecular autopsy analyzing known variants of arrhythmia-associated genes, in particular NOS1AP, may assist in establishing a cause of death for bodies found in water without clear drowning signs.	Water	201-206	nitric oxide synthase 1 adaptor protein	Homo sapiens	129-135
27704861-9	2016	Here, we report a residue-specific water accessibility experiment for a small membrane protein, sarcolipin (SLN), embedded in oriented lipid bicelles as probed by new water-edited SLF (WE-SLF) experiments.	Water	35-40	sarcolipin	Homo sapiens	96-106
27704861-9	2016	Here, we report a residue-specific water accessibility experiment for a small membrane protein, sarcolipin (SLN), embedded in oriented lipid bicelles as probed by new water-edited SLF (WE-SLF) experiments.	Water	35-40	sarcolipin	Homo sapiens	108-111
27682503-2	2016	The water-soluble, monomeric form of these toxins shows a dramatic conformational change during pore formation, as exemplified by crystal structures of the monomer and functional pore of cytolysin A (ClyA).	Water	4-9	perforin 1	Homo sapiens	187-196
27782458-3	2016	In particular, molecular dynamics simulations with accurate water potentials are used to study the energetics of the formation of structure I (sI) and II (sII) clathrate hydrates of methane, ethane, and propane.	Water	60-65	S-phase kinase associated protein 1	Homo sapiens	130-153
27474578-3	2016	Four water-soluble polysaccharides named as BP1-1, BP1-2, BP1-3 and BP1-4, with molecular weight of 35.8, 32.4, 30.1 and 27.7kDa, were purified by DEAE Sepharose and Superdex 200 chromatography.	Water	5-10	BP12	Homo sapiens	51-56
27627061-8	2016	Our trajectories indicate that the temperature-dependent burial of hydrophobic patches in the ELP region, coupled to the local water structure dynamics and mediated by intramolecular contacts between aliphatic side chains, correlates with the temperature-dependent structural transitions in known ELP polymers.	Water	127-132	nuclear receptor subfamily 5 group A member 1	Homo sapiens	94-97
27627061-8	2016	Our trajectories indicate that the temperature-dependent burial of hydrophobic patches in the ELP region, coupled to the local water structure dynamics and mediated by intramolecular contacts between aliphatic side chains, correlates with the temperature-dependent structural transitions in known ELP polymers.	Water	127-132	nuclear receptor subfamily 5 group A member 1	Homo sapiens	297-300
27498942-0	2016	In vitro study comparing the efficacy of the water-soluble HSP90 inhibitors, 17-AEPGA and 17-DMAG, with that of the non-water-soluble HSP90 inhibitor, 17-AAG, in breast cancer cell lines.	Water	45-50	heat shock protein 90 alpha family class A member 1	Homo sapiens	59-64
27694161-8	2016	These results reveal a novel pathway that contributes to the regulation of AQP2-mediated water reabsorption and suggest new potential therapeutic strategies for NDI treatment.	Water	89-94	aquaporin 2	Mus musculus	75-79
27609140-5	2016	Aquaporin-5 may promote cell movement by increasing water uptake into the front of the cell allowing local swelling.	Water	52-57	aquaporin 5	Homo sapiens	0-11
27318573-10	2016	The results confirm the result of our early study that the sources of 129I in the North Sea are primarily the nuclear reprocessing facilities at Sellafield (UK) and La Hague (F), and that in the Baltic Sea the inflow of water from North Sea through the Danish Straits dominates the occurrence of 129I.	Water	220-225	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	202-205
27318573-10	2016	The results confirm the result of our early study that the sources of 129I in the North Sea are primarily the nuclear reprocessing facilities at Sellafield (UK) and La Hague (F), and that in the Baltic Sea the inflow of water from North Sea through the Danish Straits dominates the occurrence of 129I.	Water	220-225	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	202-205
27317134-4	2016	The APCS-MLR apportioned their contributions to each water quality variable.	Water	53-58	amyloid P component, serum	Homo sapiens	4-8
3409588-5	1988	When the upper extremity was cooled with ice water before application of the tourniquet, however, the increase of serum myoglobin was statistically significantly inhibited when compared with the normothermic condition.	Water	45-50	myoglobin	Homo sapiens	120-129
27140034-6	2016	Results in water group C (tap water from a city also located in a region with intensive agricultural activity, but from the hydrological basin of the river Xuquer) revealed a non-reversible effect on fertility rate.	Water	11-16	transporter associated with antigen processing, subunit type c	Danio rerio	26-29
27140034-6	2016	Results in water group C (tap water from a city also located in a region with intensive agricultural activity, but from the hydrological basin of the river Xuquer) revealed a non-reversible effect on fertility rate.	Water	30-35	transporter associated with antigen processing, subunit type c	Danio rerio	26-29
27542006-12	2016	Furthermore, transient expression of down-regulated ARF10 or up-regulated ABI5 in tomato leaves demonstrated that ARF10 is the direct factor for inducing the water loss in 35S:mSlARF10-6.	Water	158-163	auxin response factor 10	Solanum lycopersicum	114-119
27542006-13	2016	Here, we show that although SlARF10 increased the ABA synthesis/signal response by regulating stomatal aperture to mitigate water loss, SlARF10 also influenced stomatal development and AQP expression to affect water transport, and both act cooperatively to control the loss of leaf water in tomato.	Water	124-129	auxin response factor 10	Solanum lycopersicum	28-35
32263763-1	2016	A convenient and rationally designed water-soluble two-photon excited fluorescence (TPEF) sensor for monitoring viscosity with specific targeting at the subcellular level remains a challenge.	Water	37-42	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	84-88
27706789-4	2016	As an inhibitor of sulfonamide carbonic anhydrase (CA), acetazolamide (AZA) may inhibit water infiltration through AQP4.	Water	88-93	aquaporin 4	Rattus norvegicus	115-119
3192611-2	1988	Aqua-Ark positions the exerciser in the center of the pool for deep-water exercise.	Water	68-73	AXL receptor tyrosine kinase	Homo sapiens	5-8
27669271-10	2016	Furthermore, in the experimental group (centuple ACE-containing water for seven days), beta2 nAChR expression decreased in many brain regions.	Water	64-69	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	93-98
3185404-3	1988	In this work LiF thermoluminescent chips are used for absolute dose rate measurements in solid water, polymethylmethacrylate (PMMA), and polystyrene.	Water	95-100	LIF interleukin 6 family cytokine	Homo sapiens	13-16
27598258-4	2016	To investigate GLUT4 translocation and its related signaling pathways, ICR mice were orally given procyanidins, EC and C3G in water at 10 mug/kg body weight.	Water	126-131	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	119-122
27530906-3	2016	We have demonstrated a new approach for synthesizing highly water-soluble and strong photoluminescence-emitting CdS quantum dots (i.e., CdS-MAA and CdS-MAA-TU) of sizes less than 3 nm.	Water	60-65	MAA	Homo sapiens	152-155
2903145-1	1988	Resonance Raman (RR) spectra of the complex of anionic semiquinoid D-amino acid oxidase (DAO) with picolinate in H2O and D2O were observed in the 300-1,750 cm-1 region.	Water	113-116	D-amino acid oxidase	Homo sapiens	67-87
27653477-1	2016	Water molecules inside a G-protein coupled receptor (GPCR) have recently been spotlighted in a series of crystal structures.	Water	0-5	C-X-C motif chemokine receptor 6	Homo sapiens	25-51
27653477-1	2016	Water molecules inside a G-protein coupled receptor (GPCR) have recently been spotlighted in a series of crystal structures.	Water	0-5	C-X-C motif chemokine receptor 6	Homo sapiens	53-57
27653477-2	2016	To decipher the dynamics and functional roles of internal water molecules in GPCR activity, we studied the A2A adenosine receptor using microsecond molecular-dynamics simulations.	Water	58-63	C-X-C motif chemokine receptor 6	Homo sapiens	77-81
27653477-5	2016	Especially, water molecules, exhibiting ultraslow relaxation (~O(10(2)) ns) in the active state, are found around the microswitch residues that are considered activity hotspots for GPCR function.	Water	12-17	C-X-C motif chemokine receptor 6	Homo sapiens	181-185
27185120-4	2016	Defect-free CMCS-ADA-PEO nanofibers with average diameters ranging from 100nm to 900nm were obtained using water as a solvent.	Water	107-112	G protein signaling modulator 2	Homo sapiens	12-16
27185120-5	2016	The in situ cross-linked CMCS-ADA nanofibers were then obtained following the extraction of water-soluble PEO.	Water	92-97	G protein signaling modulator 2	Homo sapiens	25-29
2903145-1	1988	Resonance Raman (RR) spectra of the complex of anionic semiquinoid D-amino acid oxidase (DAO) with picolinate in H2O and D2O were observed in the 300-1,750 cm-1 region.	Water	113-116	D-amino acid oxidase	Homo sapiens	89-92
3402367-0	1988	Otovestibular toxicity and Dead Sea water.	Water	36-41	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	32-35
27010511-4	2016	This study examines the reliability of a popular sharp-interface analytical approach for estimating the extent of sea water in a homogeneous coastal aquifer subjected to pumping and regional flow effects and under steady-state conditions.	Water	118-123	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	114-117
27509294-2	2016	In addition to factors related to homeostasis of the inner ear, genetic factors have been implicated in its pathophysiology, including genes related to the transport of water and ionic composition maintenance of the endolymph, such as the aquaporin genes AQP2 and AQP3, and the potassium channel gene KCNE1.	Water	169-174	aquaporin 3 (Gill blood group)	Homo sapiens	264-268
27649298-5	2016	Here we reported that S-propargyl-cysteine (SPRC), a novel water-soluble H2S donor, suppressed hepatic hepcidin and corrected hypoferremia induced by lipopolysaccharide.	Water	59-64	hepcidin antimicrobial peptide	Homo sapiens	103-111
27581320-3	2016	AQP4 channels are implicated in the pathophysiology of hydrocephalus, a disease of water imbalance that leads to CSF accumulation in the ventricular system.	Water	83-88	colony stimulating factor 2	Homo sapiens	113-116
3260494-1	1988	The molecular forms of corticotrophin-releasing hormone (CRH) in human placentae and hypothalami were investigated by gel permeation chromatography of water extracts.	Water	151-156	corticotropin releasing hormone	Homo sapiens	23-55
27581320-5	2016	Drug therapy targeting AQP channels may enable control over water exchange to remove excess CSF through a molecular intervention instead of by mechanical shunting.	Water	60-65	colony stimulating factor 2	Homo sapiens	92-95
32263471-6	2016	The peptide concentration (0   40 mg mL-1) was found to primarily affect the internal structure of the fabric at the nano-scale, whilst water as well as cell culture medium contact angles were dramatically decreased.	Water	136-141	L1 cell adhesion molecule	Mus musculus	37-41
26926783-0	2016	Gravimetric water distribution assessment from geoelectrical methods (ERT and EMI) in municipal solid waste landfill.	Water	12-17	elastin microfibril interfacer 1	Homo sapiens	78-81
3260494-1	1988	The molecular forms of corticotrophin-releasing hormone (CRH) in human placentae and hypothalami were investigated by gel permeation chromatography of water extracts.	Water	151-156	corticotropin releasing hormone	Homo sapiens	57-60
27109247-1	2016	To probe the dynamic nature of the hydrogen bond network in water, linear and nonlinear infrared spectra of dilute HOD in H2O are computed from many-body molecular dynamics simulations with the MB-pol potential, which have been shown to accurately predict the properties of water from the gas to the condensed phase.	Water	122-125	HOP homeobox	Homo sapiens	115-118
27109247-1	2016	To probe the dynamic nature of the hydrogen bond network in water, linear and nonlinear infrared spectra of dilute HOD in H2O are computed from many-body molecular dynamics simulations with the MB-pol potential, which have been shown to accurately predict the properties of water from the gas to the condensed phase.	Water	274-279	HOP homeobox	Homo sapiens	115-118
27192358-9	2016	At village-level, prevalence of fecal pathogen detection in community drinking water sources was associated with elevated prevalence of child diarrhea within 6 weeks of testing (RR 2.13, 95%CI: 1.25-3.63) while within homes, higher levels of human and animal fecal marker detection were associated with increased risks of subsequent child diarrhea (P = 0.044 and 0.013, respectively).	Water	79-84	ribonucleotide reductase regulatory subunit M2	Homo sapiens	178-182
3403427-1	1988	The present work was undertaken to determine the effect of atmospheric pressure [ranging from a high altitude of 4,300 m above sea level or 0.6 atmospheres absolute (ATA) to depths of 10 m deep or 2 ATA] on the critical water temperature (Tcw), defined as the lowest water temperature a subject can tolerate at rest for 2 h without shivering, of the unprotected subject during water immersion.	Water	220-225	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	127-130
27294337-3	2016	The chloro ligand hydrolysis slowly and the octanol and water partition coefficient of Ru2-Ru4 were between 0.6 and 1.2.	Water	56-61	doublecortin domain containing 2	Homo sapiens	87-90
3415970-1	1988	By use of two-dimensional NMR techniques most of the proton resonances (greater than 90%) are assigned for the tryptic digest fragment 96-133 of bovine somatotropin in 30% 2,2,2-trifluoroethanol-d3/70% H2O.	Water	202-205	somatotropin	Bos taurus	152-164
27378083-7	2016	These water-dynamic behaviors and PMF confirm that Leu21 is the key residue that regulates the ion permeability of the pentameric SLN channel.	Water	6-11	sarcolipin	Homo sapiens	130-133
3284678-6	1988	The BMP implant was prepared in the form of an aggregate of h-BMP and bone matrix water-insoluble noncollagenous proteins (h-BMP/iNCP).	Water	82-87	bone morphogenetic protein 1	Homo sapiens	4-7
26546722-1	2016	AIMS: Endothelin-1 (ET-1) is an autocrine inhibitor of collecting duct (CD) Na(+) and water reabsorption.	Water	86-91	endothelin 1	Mus musculus	6-18
26546722-1	2016	AIMS: Endothelin-1 (ET-1) is an autocrine inhibitor of collecting duct (CD) Na(+) and water reabsorption.	Water	86-91	endothelin 1	Mus musculus	20-24
28920384-5	2016	Morris water maze test showed that the escape latency of APP/PS1 double transgenic mice was significantly longer than that of the normal control group, and the residence time of the original quadrant was significantly shorter.	Water	7-12	presenilin 1	Mus musculus	61-64
3366749-5	1988	This effect required catalase enzyme activity, as demonstrated by the failure of enzymatically inactivated catalase (by reaction in vitro with aminotriazole in the presence of H2O2) or catalase vehicle (0.1% thymol in water) to affect the lung lymph response to air emboli.	Water	218-223	catalase	Ovis aries	21-29
27573802-9	2016	The excess in precipitable water is transported from the Mediterranean Sea to Central Europe causing stronger precipitation extremes over that region.	Water	27-32	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	71-74
27410160-1	2016	The anharmonic spectra of the gas phase cubic water octamer (W8, D2d and S4 isomers) have been theoretically calculated at the second order Moller-Plesset perturbation (MP2) and the coupled cluster with single, double and a perturbative estimate of triple replacements [CCSD(T)] theories.	Water	46-51	tryptase pseudogene 1	Homo sapiens	169-172
27252474-0	2016	Nax signaling evoked by an increase in [Na+] in CSF induces water intake via EET-mediated TRPV4 activation.	Water	60-65	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	90-95
27252474-3	2016	We herein investigated voluntary water intake immediately induced after an intracerebroventricular administration of a hypertonic NaCl solution in TRPV1-, TRPV4-, Nax-, and their double-gene knockout (KO) mice.	Water	33-38	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	155-160
3354024-6	1988	That the increased brain water content was causally related to an increase in leukotriene C4 was supported by results obtained following administration of the 5-lipoxygenase inhibitors ONO-LP-016 and AA-861.	Water	25-30	arachidonate 5-lipoxygenase	Rattus norvegicus	159-173
27143639-5	2016	The administration of exogenous water-soluble CoQ10 to aged mice via drinking water restored the mitochondrial OCR, motor function, and phosphorylated alpha-syn and VGluT1 levels in the motor cortex.	Water	32-37	synuclein, alpha	Mus musculus	151-160
27143639-5	2016	The administration of exogenous water-soluble CoQ10 to aged mice via drinking water restored the mitochondrial OCR, motor function, and phosphorylated alpha-syn and VGluT1 levels in the motor cortex.	Water	78-83	synuclein, alpha	Mus musculus	151-160
27016454-1	2016	What chemical species might be found if water or ammonia reacts with HCN in aqueous solution under neutral conditions?	Water	40-45	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	69-72
27193425-3	2016	In contrast, in morulae (and probably blastocysts), water, glycerol, and ethylene glycerol move rapidly, principally by facilitated diffusion via aquaporin 3, and DMSO moves rapidly via channels other than aquaporin 3.	Water	52-57	aquaporin 3 (Gill blood group)	Homo sapiens	146-157
3400170-0	1988	[The role of macro-ions of Naftusia mineral water in its gastrin-incretory effect (experimental study)].	Water	44-49	gastrin	Homo sapiens	57-64
27487325-4	2016	The barrier height along the lowest-energy pathway in the reaction between CO and OH in the absence of the H2O molecule was calculated to be 2.3 kcal/mol when CCSD(T) energy corrections are combined with the MP2 basis set limit.	Water	107-110	tryptase pseudogene 1	Homo sapiens	208-211
27344956-8	2016	The LPLA2 activity in the rat AH was increased by EAU induction, and was concomitant with the extent of inflammation in the anterior chamber (AC).	Water	50-53	phospholipase A2, group XV	Rattus norvegicus	4-9
3365393-0	1988	Conformational studies of human Des-Trp1,Nle12-minigastrin in water-trifluoroethanol mixtures by 1H NMR and circular dichroism.	Water	62-67	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	36-40
27467899-7	2016	Site-specific fluorescence experiments using single Trp variants of beta2m revealed that the middle region of the protein is incorporated into these oligomers, whereas the C-terminal segment is highly exposed to bulk water.	Water	217-222	beta-2-microglobulin	Homo sapiens	68-74
3278629-4	1988	Administration of an ANG II receptor antagonist (ANG IIX) to water-deprived animals produced a small decrease in MAP but no significant changes in HR or mesenteric and hindquarters vascular resistances.	Water	61-66	angiogenin	Oryctolagus cuniculus	21-24
28487901-7	2016	Water extract and ethanol extract could significantly reduce GOT activity (P&lt;0.001) and GPT activity (P&lt;0.001) in serum, reduce significantly the content of MDA (P&lt;0.001) and significantly increase SOD activity (P&lt;0.001) in the mice liver tissue homogenate.	Water	0-5	glutamic pyruvic transaminase, soluble	Mus musculus	91-94
26375875-4	2016	RESULTS: Simulations indicated that a two-pool fitting of four-pool data yielded accurate measures of pool size ratio (PSR) of macromolecular versus free water protons when there were fast transcytolemmal exchange and slow R1 recovery.	Water	154-159	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	119-122
3278629-4	1988	Administration of an ANG II receptor antagonist (ANG IIX) to water-deprived animals produced a small decrease in MAP but no significant changes in HR or mesenteric and hindquarters vascular resistances.	Water	61-66	angiogenin	Oryctolagus cuniculus	49-52
27359276-1	2016	Dealing with the water molecule on the surface of LiNi0.6Co0.2Mn0.2O2 (NCM) cathode and hydrogen fluoride in the electrolyte is one of the most difficult challenges in Li-ion battery research.	Water	17-22	CWC22 spliceosome associated protein homolog	Homo sapiens	71-74
3278629-11	1988	However, activation of sympathetic nerve activity may become important in maintaining peripheral resistance when ANG II and AVP receptors are blocked in water-deprived animals.	Water	153-158	angiogenin	Oryctolagus cuniculus	113-116
2893612-2	1988	With glycylglycine or water as acceptor, bovine kidney gamma-glutamyltransferase catalyzes reactions of the known mammalian metabolite, S-oxalylglutathione, at rates comparable to those of L-gamma-glutamyl-p-nitroanilide, a known good substrate.	Water	22-27	gamma-glutamyltransferase light chain family member 3	Homo sapiens	55-80
27353249-1	2016	In this work we use molecular dynamics simulations to study the diffusion of N,N-dimethylformamide (DMF) and H2O as a function of temperature within the well-known metal-organic framework Co2(dobdc) [G] (G = 2DMF 1H2O), also known as Co-MOF-74.	Water	109-112	complement C2	Homo sapiens	188-198
27410682-7	2016	Analysis of climatological data from a high resolution Regional Ocean Modeling System reveals that the complex bathymetry is important not only for water exchange through the Southern South China Sea but also in regulating various transports across the main passages in the Southern South China Sea, namely the Sunda Shelf and the Strait of Malacca.	Water	148-153	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	196-199
27410682-7	2016	Analysis of climatological data from a high resolution Regional Ocean Modeling System reveals that the complex bathymetry is important not only for water exchange through the Southern South China Sea but also in regulating various transports across the main passages in the Southern South China Sea, namely the Sunda Shelf and the Strait of Malacca.	Water	148-153	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	295-298
27414989-10	2016	The interaction energies for the azaborine with one water calculated with the SAPT(DFT), MP2, SCS-MP2, and MP2C methods are in satisfactory agreement with each other.	Water	52-57	tryptase pseudogene 1	Homo sapiens	89-92
27414989-10	2016	The interaction energies for the azaborine with one water calculated with the SAPT(DFT), MP2, SCS-MP2, and MP2C methods are in satisfactory agreement with each other.	Water	52-57	tryptase pseudogene 1	Homo sapiens	98-101
2825377-11	1987	Water-soluble 2,3-dimercapto-1-propane sulfonate, a BAL analog, was largely ineffective as an inhibitor.	Water	0-5	poly(ADP-ribose) polymerase family member 9	Homo sapiens	52-55
27491540-4	2016	We found two specific water molecules that were common to 92 DPP-4 structures.	Water	22-27	dipeptidyl peptidase 4	Homo sapiens	61-66
27525904-1	2016	Aquaporin (AQP) 3 and AQP4 are important in urine concentrating mechanisms and in other physiological functions such as brain water balance, cell migration, cell proliferation, fat metabolism, and epidermal hydration.	Water	126-131	aquaporin 3 (Gill blood group)	Rattus norvegicus	0-17
27525904-1	2016	Aquaporin (AQP) 3 and AQP4 are important in urine concentrating mechanisms and in other physiological functions such as brain water balance, cell migration, cell proliferation, fat metabolism, and epidermal hydration.	Water	126-131	aquaporin 4	Rattus norvegicus	22-26
27409611-1	2016	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel responsible for regulating water reabsorption through the apical plasma membrane of the principal cells of renal collecting ducts.	Water	46-51	aquaporin 2	Homo sapiens	0-11
27409611-1	2016	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel responsible for regulating water reabsorption through the apical plasma membrane of the principal cells of renal collecting ducts.	Water	46-51	aquaporin 2	Homo sapiens	13-17
27409611-1	2016	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel responsible for regulating water reabsorption through the apical plasma membrane of the principal cells of renal collecting ducts.	Water	87-92	aquaporin 2	Homo sapiens	0-11
27409611-1	2016	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel responsible for regulating water reabsorption through the apical plasma membrane of the principal cells of renal collecting ducts.	Water	87-92	aquaporin 2	Homo sapiens	13-17
27409611-5	2016	Here, we briefly review the progress of studies in this area and discuss the role of nuclear receptors in the regulation of water reabsorption via affecting AQP2 expression and function.	Water	124-129	aquaporin 2	Homo sapiens	157-161
3673910-3	1987	The metal tip catheter can be heated rapidly and boils water in a saline bath with less than 1 W of power.	Water	55-60	TOR signaling pathway regulator	Homo sapiens	10-13
26869465-6	2016	Concordance between low CSF pressure (&lt;=6 cm H2O) and imaging was defined as the presence of the sign in a subject with low CSF pressure or absence of the sign when pressure was not low.	Water	48-51	colony stimulating factor 2	Homo sapiens	24-27
26868517-0	2016	Concentration of MS2 phage in river water by a combined ferric colloid adsorption and foam separation-based method, with MS2 phage leaching from ferric colloid.	Water	36-41	MS2	Homo sapiens	17-20
26868517-0	2016	Concentration of MS2 phage in river water by a combined ferric colloid adsorption and foam separation-based method, with MS2 phage leaching from ferric colloid.	Water	36-41	MS2	Homo sapiens	121-124
3479781-3	1987	Bilirubin ditaurine (BR-DT), a water-soluble model compound of conjugated bilirubin, completely prevents the peroxyl radical-induced oxidation of phosphatidylcholine in either multilamellar liposomes or micelles.	Water	31-36	bromodomain testis associated	Homo sapiens	0-26
27189888-0	2016	Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents.	Water	97-102	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	43-68
3667605-7	1987	The latter released a water-soluble mannose-labeled moiety which eluted from Bio-Gel P-6 in a manner similar to Glc3Man9GlcNAc2.	Water	22-27	exosome component 9	Homo sapiens	85-88
27367163-3	2016	These molecules correspond to lyso-Gb3 with different chemical modifications on the sphingosine chain (-C2 H4 , -H2 , +O, +H2 O, +H2 O2, and +H2 O3 ).	Water	123-127	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	35-38
2827627-11	1987	The results suggest the presence of a labile water molecule at the iron-binding sites of ovotransferrin in solution.	Water	45-50	transferrin (ovotransferrin)	Gallus gallus	89-103
30035996-0	2016	[Application of the Identification of Mine Water Inrush with LIF Spectrometry and KNN Algorithm Combined with PCA].	Water	43-48	LIF interleukin 6 family cytokine	Homo sapiens	61-64
19456982-1	1987	Synopsis A phenomenon of increased permeation as a function of time in the percutaneous absorption of urea and water led to this in vitro study with skin of hairless mice in a closed diffusion cell system.	Water	111-116	lysine demethylase and nuclear receptor corepressor	Mus musculus	157-165
20490009-0	1987	Atmospheric remote sensing of water vapor, HCl and CH(4) using a continuously tunable Co:MgF(2) laser.	Water	30-35	signal transducer and activator of transcription 5A	Homo sapiens	89-92
26768614-3	2016	Aquaporin 3 (AQP3) belongs to a family of transmembrane channels that are important in transporting water, glycerol, and other small molecules across the cell membrane.	Water	100-105	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
26768614-3	2016	Aquaporin 3 (AQP3) belongs to a family of transmembrane channels that are important in transporting water, glycerol, and other small molecules across the cell membrane.	Water	100-105	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
27369531-2	2016	It is found that in the case of Cu-MOR and Ag-MOR, the absolute values of interaction energies of ICH3 and I2 are higher than that of water which indicates that these forms of zeolite could be suitable for selective adsorption of iodine species.	Water	134-139	opioid receptor mu 1	Homo sapiens	35-38
27369531-2	2016	It is found that in the case of Cu-MOR and Ag-MOR, the absolute values of interaction energies of ICH3 and I2 are higher than that of water which indicates that these forms of zeolite could be suitable for selective adsorption of iodine species.	Water	134-139	opioid receptor mu 1	Homo sapiens	46-49
27369531-5	2016	For the Ag-MOR and Cu-MOR zeolites, the iodine compounds are adsorbed preferentially in the large channel of mordenite (main channel) while water prefers the small channel or the side pocket where it forms stronger hydrogen bonds.	Water	140-145	opioid receptor mu 1	Homo sapiens	22-25
2436487-7	1987	Exposure of the tissue"s mucosal surface to GM1 ganglioside, (the natural receptor for the CT b subunit) yielded maximal stimulation of water flow and near-maximal urea transport, presumably by increasing CT"s binding to the cell membrane.	Water	136-141	chitobiase	Homo sapiens	91-95
27283079-5	2016	In this paper, we firstly determined the most stable CdS and ZnS(110) termination under the conditions of photocatalytic HER, i.e., pure (110), by calculating the free energies of three reactions related to H2O dissociation on (110).	Water	207-210	CDP-diacylglycerol synthase 1	Homo sapiens	53-56
2436925-6	1987	These results suggest an important role in the pathogenesis of EAU for the epitopes recognized by S2D2-S6H8 and S7D6 in the S-Ag molecule.	Water	63-66	S-antigen visual arrestin	Rattus norvegicus	124-128
27137845-0	2016	Dynamics of Hydration Water around Native and Misfolded alpha-Lactalbumin.	Water	22-27	lactalbumin alpha	Bos taurus	56-73
27137845-2	2016	We investigate water dynamics around bovine alpha-lactalbumin by combining molecular dynamics simulations with polarization-resolved femtosecond infrared (fs-IR) spectroscopy.	Water	15-20	lactalbumin alpha	Bos taurus	44-61
3031064-5	1987	Analysis of labeled water-soluble compounds from prelabeled cells indicated a rapid (within 1 min) stimulation of inositol phospholipid hydrolysis following IL-2 treatment.	Water	20-25	interleukin 2	Mus musculus	157-161
27049790-9	2016	Additionally, the pH and salinity effects on the OTC photo-degradation were evaluated and it has been shown that high pH values and the presence of sea salt increase the OTC photo-degradation rate in aquaculture"s waters, compared to results in deionised water.	Water	214-219	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	148-151
2434225-3	1987	In the target lymph node of the iliac lymph node, the level of BLM emulsion continuously was greater than 2 micrograms/g for 9 hours after the injection, while the level of BLM water solution decreased rapidly.	Water	177-182	BLM RecQ like helicase	Rattus norvegicus	173-176
27131751-3	2016	We examined the effects of maternal rat ingestion of Pb in drinking water during gestation and lactation on the expression of SIRT1 and CREB in the hippocampus of their offspring at postnatal week 3 (PNW3) and 52 (PNW52), and then reexamined these effects in offspring after intragastric administration of resveratrol for 4 weeks.	Water	68-73	cAMP responsive element binding protein 1	Rattus norvegicus	136-140
2434225-6	1987	Survival rate in rats treated with BLM emulsion was significantly higher than that in control groups and was slightly higher than that in the group given BLM water solution iv.	Water	158-163	BLM RecQ like helicase	Rattus norvegicus	154-157
3803590-1	1987	A major difference between porcine and bovine pancreatic phospholipase A2 (PA2) is the relatively low affinity of the bovine enzyme for lipid-water interfaces.	Water	142-147	LOC104974671	Bos taurus	57-73
3803590-1	1987	A major difference between porcine and bovine pancreatic phospholipase A2 (PA2) is the relatively low affinity of the bovine enzyme for lipid-water interfaces.	Water	142-147	LOC104974671	Bos taurus	75-78
3780165-3	1986	During mouth breathing, temperatures are significantly higher (TI = 28.1 degrees C, TE = 31.5 degrees C) and the amount of expired water larger (MEH2O = 27.8 mg dm-3 BTPS) than during nose breathing (TI = 24.8 degrees C; TE = 29.6 degrees C; MEH2O = 26.6 mg dm-3 BTPS).	Water	131-136	epoxide hydrolase 1	Homo sapiens	145-148
3781744-2	1986	Modification of approximately one fifth of the carboxylate groups in bovine somatotropin with a water soluble carbodiimide caused loss of growth promoting potency pointing to the existence of residues related to the hormonal activity among those belonging to a fast reacting set.	Water	96-101	somatotropin	Bos taurus	76-88
3531087-1	1986	Since a water-soluble polysaccharide (KGF-C) from the kefir grains was shown to have the property of retarding tumor growth in vivo when administered orally, the effect of KGF-C was examined on antibody responses to thymus-dependent antigen, sheep red blood cells (SRBC), and thymus-independent antigen, dinitrophenyl-Ficoll and trinitrophenyl-lipopolysaccharide.	Water	8-13	fibroblast growth factor 7	Mus musculus	38-41
3752940-2	1986	Using DCC procedure as the basis, the extraction and incubation of ER and PgR is more efficiently achieved by phosphate buffer as compared with water, tris and veronal buffers.	Water	144-149	progesterone receptor	Oryctolagus cuniculus	74-77
2941444-6	1986	However, the removal of cellular water by exposure of cells to hypertonic medium during mitosis blocked the reformation of the nucleus and trapped the snRNP particles in the cytoplasm.	Water	33-38	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	151-156
3717373-4	1986	Water deprivation for 48 h increased the plasma vasopressin concentration (PADH) and 24-h urinary vasopressin excretion (UADHV) in SHR and WKY rats, but PMet-Enk was not altered.	Water	0-5	proenkephalin	Rattus norvegicus	158-161
3458181-7	1986	[Leu5]Enkephalin crystallizes as a monohydrate that is isomorphous with the [Met5]enkephalin structure with respect to the beta-sheet but different with respect to the tyrosine and phenylalanine side-chain conformations and water content.	Water	224-229	tripartite motif containing 13	Homo sapiens	1-5
2874262-5	1986	A monooxygenase-like enzymatic activity of D-amino acid oxidase with these novel substrates is considered, for which the final products are hypothesized to be protein alpha-carbon hydroxyls resulting from the incorporation of one atom of oxygen into the substrate, the other being reduced to water.	Water	292-297	D-amino acid oxidase	Homo sapiens	43-63
27562703-0	2016	Water-extracted Perilla frutescens increases endometrial receptivity though leukemia inhibitory factor-dependent expression of integrins.	Water	0-5	LIF interleukin 6 family cytokine	Homo sapiens	76-102
27181510-10	2016	AQP1 upregulation/AQP4 downregulation induced under subtoxic 3NP treatment may play a pivotal role in water homeostasis and cell viability in the striatum.	Water	102-107	aquaporin 4	Rattus norvegicus	18-22
3510622-6	1986	With the use of a novel in situ assay which measured the release of [3H]water from [5-3H] uridine in intact cells, we were able to show that one of the earliest biochemical events is the inhibition of ribonucleotide reductase and that the inhibition of thymidylate synthase, which is delayed by approximately 30 min, was indirectly mediated possibly through effects on ribonucleotide reductase.	Water	72-77	thymidylate synthetase	Homo sapiens	253-273
27402760-2	2016	Reabsorption of water from the luminal fluid of the nephron occurs through aquaporin-2 (AQP2) water pores in principal cells that line the kidney-collecting duct.	Water	16-21	aquaporin 2	Mus musculus	75-86
27402760-2	2016	Reabsorption of water from the luminal fluid of the nephron occurs through aquaporin-2 (AQP2) water pores in principal cells that line the kidney-collecting duct.	Water	16-21	aquaporin 2	Mus musculus	88-92
27402760-2	2016	Reabsorption of water from the luminal fluid of the nephron occurs through aquaporin-2 (AQP2) water pores in principal cells that line the kidney-collecting duct.	Water	94-99	aquaporin 2	Mus musculus	75-86
27402760-2	2016	Reabsorption of water from the luminal fluid of the nephron occurs through aquaporin-2 (AQP2) water pores in principal cells that line the kidney-collecting duct.	Water	94-99	aquaporin 2	Mus musculus	88-92
3951788-1	1986	Cis-dichloro-trans-dihydroxy-bis(isopropylamine)platinum IV (CHIP) is a second-generation cis-platinum (DDP) derivative with an octahedral conformation of the platinum complex, far more water-soluble than DDP.	Water	186-191	translocase of inner mitochondrial membrane 8A	Homo sapiens	104-107
27455244-7	2016	In conclusion, the AQP1 water channel located in the vessels of WAT is up-regulated in response to prolonged starvation in the WAT of AQP7 KO mice.	Water	24-29	aquaporin 7	Mus musculus	134-138
27167134-0	2016	Origins of suspended particulate matter based on sterol distribution in low salinity water mass observed in the offshore East China Sea.	Water	85-90	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	132-135
27189135-1	2016	Water-soluble N-(2-hydroxypropyl)methacrylamide copolymer conjugates bearing the anticancer drugs doxorubicin (Dox) or pirarubicin (THP), P-gp inhibitors derived from reversin 121 (REV) or ritonavir (RIT)), or both anticancer drug and P-gp inhibitor were designed and synthesized.	Water	0-5	phosphoglycolate phosphatase	Homo sapiens	138-142
27189135-1	2016	Water-soluble N-(2-hydroxypropyl)methacrylamide copolymer conjugates bearing the anticancer drugs doxorubicin (Dox) or pirarubicin (THP), P-gp inhibitors derived from reversin 121 (REV) or ritonavir (RIT)), or both anticancer drug and P-gp inhibitor were designed and synthesized.	Water	0-5	phosphoglycolate phosphatase	Homo sapiens	235-239
27118174-7	2016	APP/PS1 mutant transgenic mice at KMS4001 doses of 3 and 30mg/kg/day via drinking water showed the significantly enhanced novel-object recognition memory at both 1.5 and 3 months after the start of KMS4001 treatment.	Water	82-87	presenilin 1	Mus musculus	4-7
27377386-5	2016	alphaHis103(G10), located in the alpha1:beta1 dimer interface, appears to be a Bohr group that undergoes structural changes: in the R state it is singly protonated/deuterated and hydrogen-bonded through a water network to betaAsn108(G10) and in the T state it is doubly protonated/deuterated with the network uncoupled.	Water	205-210	adrenoceptor alpha 1D	Homo sapiens	33-45
26935740-11	2016	Furthermore, Morris water maze showed that 4 months-old APP/PS1 mice have normal spatial learning and impaired spatial memory; both spatial learning and spatial memory in 12 and 22 months-old APP/PS1 mice were declined.	Water	20-25	presenilin 1	Mus musculus	60-63
26815506-2	2016	In this study, we tested the anti-tumor effect of compound A13, a water-soluble analogue of curcumin, in vitro and in vivo.	Water	66-71	UDP glycosyltransferase 1 family, polypeptide A10	Mus musculus	59-62
27446930-1	2016	Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial methylmalonyl-CoA mutase (MCM).	Water	54-59	Cbl proto-oncogene	Homo sapiens	24-27
27120557-8	2016	Some physical characteristics such as the origin of emulsion, electrical conductivity, and the local structure of water molecules in the KCC-1 emulsion were disclosed to reveal the formation mechanism of KCC-1.	Water	114-119	solute carrier family 12 member 4	Homo sapiens	137-142
27120557-8	2016	Some physical characteristics such as the origin of emulsion, electrical conductivity, and the local structure of water molecules in the KCC-1 emulsion were disclosed to reveal the formation mechanism of KCC-1.	Water	114-119	solute carrier family 12 member 4	Homo sapiens	204-209
27142221-0	2016	The quenching effect of uranyl species in the photoluminescence emission and visible-light-driven water dissociation activity of CdS and TiO2 photocatalysts.	Water	98-103	CDP-diacylglycerol synthase 1	Homo sapiens	129-132
27181021-0	2016	Hollow CoP nanopaticle/N-doped graphene hybrids as highly active and stable bifunctional catalysts for full water splitting.	Water	108-113	caspase recruitment domain family member 16	Homo sapiens	7-10
27276267-3	2016	Here, we investigate the role of water in actin-myosin binding using the most reliable statistical-mechanical method currently available for assessing biomolecules immersed in water.	Water	33-38	myosin heavy chain 14	Homo sapiens	48-54
27276267-6	2016	However, these gains are accompanied by even larger losses of actin-water and myosin-water electrostatic and LJ attractive interactions.	Water	85-90	myosin heavy chain 14	Homo sapiens	78-84
27276267-9	2016	Importantly, the binding is driven by a large gain of configurational entropy of water, which surpasses the positive change in system energy and the conformational entropy loss occurring for actin and myosin.	Water	81-86	myosin heavy chain 14	Homo sapiens	201-207
27276267-10	2016	The principal physical origin of the large water-entropy gain is as follows: the actin-myosin interface is closely packed with the achievement of high shape complementarity on the atomic level, leading to a large increase in the total volume available to the translational displacement of water molecules in the system and a resultant reduction of water crowding (i.e., entropic correlations among water molecules).	Water	43-48	myosin heavy chain 14	Homo sapiens	87-93
27276267-10	2016	The principal physical origin of the large water-entropy gain is as follows: the actin-myosin interface is closely packed with the achievement of high shape complementarity on the atomic level, leading to a large increase in the total volume available to the translational displacement of water molecules in the system and a resultant reduction of water crowding (i.e., entropic correlations among water molecules).	Water	289-294	myosin heavy chain 14	Homo sapiens	87-93
27276267-10	2016	The principal physical origin of the large water-entropy gain is as follows: the actin-myosin interface is closely packed with the achievement of high shape complementarity on the atomic level, leading to a large increase in the total volume available to the translational displacement of water molecules in the system and a resultant reduction of water crowding (i.e., entropic correlations among water molecules).	Water	289-294	myosin heavy chain 14	Homo sapiens	87-93
27276267-10	2016	The principal physical origin of the large water-entropy gain is as follows: the actin-myosin interface is closely packed with the achievement of high shape complementarity on the atomic level, leading to a large increase in the total volume available to the translational displacement of water molecules in the system and a resultant reduction of water crowding (i.e., entropic correlations among water molecules).	Water	289-294	myosin heavy chain 14	Homo sapiens	87-93
27285932-8	2016	The EBP (percentage of water-free EBW) plotted against the EBW using the exponential function enabled us to estimate the mature weight of intact and castrated males and females as 83.9, 33.6, and 26.4 kg EBW, respectively, indicating that the decrease of protein accretion of intact males approaches zero later than in females and castrated males during growth.	Water	23-28	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Capra hircus	4-7
26909767-6	2016	We established that zebrafish has endogenous beta-glucosidase activity toward lipid- and water-soluble GBA2 substrates, which can be inhibited by miglustat, N-butyldeoxygalactonojirimycin, and conduritol B epoxide.	Water	89-94	glucosidase, beta (bile acid) 2	Danio rerio	103-107
27125188-4	2016	In tap water, the limits of quantification (LOQs) were found to be between 20ng/L and 100ng/L depending on the analyte, with mean recoveries ranging from 76 to 126%.	Water	7-12	TARBP2 subunit of RISC loading complex	Homo sapiens	44-48
27140635-3	2016	The present work revealed that aquaporin 5 expression, a water channel critical for salivary gland fluid secretion, is regulated by bone morphogenetic protein 6.	Water	57-62	bone morphogenetic protein 6	Mus musculus	132-160
27398307-0	2016	Understanding the dynamics of monomeric, dimeric, and tetrameric alpha-synuclein structures in water.	Water	95-100	synuclein alpha	Homo sapiens	65-80
27025854-12	2016	2-APB reduced the serum levels of amylase, TNF-alpha, and IL-6, and attenuated lung water content and histological findings.	Water	84-89	arginyl aminopeptidase	Rattus norvegicus	2-5
26990788-6	2016	It was found that simulations employing explicit water implemented using the TIP3 model generally performed significantly better than those using implicit water in reproducing experimental methyl symmetry axis O(2) values.	Water	49-54	suppressor of cytokine signaling 1	Homo sapiens	77-81
27223295-7	2016	There were associations between urinary CC16 and arsenic concentration in soil (b = -0.43, p = 0.001, R2 = 0.08), water (b = -0.22, p = 0.07, R2 = 0.03), house dust (b = -0.37, p = 0.07, R2 = 0.04), and dust loading (b = -0.21, p = 0.04, R2 = 0.04).	Water	114-119	secretoglobin family 1A member 1	Homo sapiens	40-44
2875541-5	1986	Water-soluble metabolites were subjected to enzymatic hydrolysis with beta-glucuronidase and aryl sulfatase to identify specific conjugated products.	Water	0-5	glucuronidase, beta	Mus musculus	70-88
3878779-4	1985	Fasting for 72 h resulted in a decrease and oral glucose administration (0.75-1.5 g given in form of 25% water solution 30 min before sacrifice) was followed by an increase of C-peptide-like immunoreactivity in both plasma and hypothalamus.	Water	105-110	insulin 2	Rattus norvegicus	176-185
32262970-2	2016	Water processed films of PDI-Lys were prepared and their self-assembly, morphology and electrical properties in both inert and air environments were theoretically and experimentally investigated.	Water	0-5	peptidyl arginine deiminase 1	Homo sapiens	25-28
3836843-1	1985	The specific efficient anti-MTX antibody was obtained from the rabbits immunized with an artificial antigen produced by condensing MTX and bovine serum albumin in water-soluble carbodi-imide.	Water	163-168	albumin	Oryctolagus cuniculus	146-159
33401818-1	2016	Electrolyzed water (EW) has gained immense popularity over the last few decades as a novel broad-spectrum sanitizer.	Water	13-18	hyaluronan synthase 1	Homo sapiens	24-27
33401818-7	2016	AEW, in particular, has shown limited efficacy on utensils, food products, and surfaces owing to various factors, the most important of which include the type of surface, presence of organic matter, and type of tape water used.	Water	216-221	hyaluronan synthase 1	Homo sapiens	20-23
3896556-8	1985	T1 and T2 in group 2 increased from day 4 and correlated well with the water content of the hearts (r = .70 and r = .75, respectively).	Water	71-76	brachyury 2	Rattus norvegicus	0-9
27127019-7	2016	The results support the bubble kinetic models and indicate that metabolic gases and water vapor contribute significantly to bubble volume at 25 kPa (~10,376 m above sea level) and constitute a threshold for bubble stabilization or decay at the interval of 47-36 kPa (~6,036 and ~7,920 m above sea level).	Water	84-89	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	165-168
27127019-7	2016	The results support the bubble kinetic models and indicate that metabolic gases and water vapor contribute significantly to bubble volume at 25 kPa (~10,376 m above sea level) and constitute a threshold for bubble stabilization or decay at the interval of 47-36 kPa (~6,036 and ~7,920 m above sea level).	Water	84-89	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	293-296
4016732-7	1985	When the substrate concentration was 4 microM and the incubation time was 24 h, beta-glucuronidase treatment of water-soluble metabolites released about 5.3 times more pmol of quinones compared with phenols.	Water	112-117	glucuronidase, beta	Mus musculus	80-98
28751831-0	2016	Water-soluble chitosan regulates vascular remodeling in hypertension via NFATc1.	Water	0-5	nuclear factor of activated T-cells 1	Rattus norvegicus	73-79
3896238-4	1985	The molar absorption coefficient of rIL-2 was determined to be 9.58 X 10(3) M-1 cm-1 at 280nm in water.	Water	97-102	interleukin 2	Rattus norvegicus	36-41
3876112-2	1985	When H2O-exchanged, lyophilized mouse epidermal growth factor (mEGF) is dissolved in deuterium oxide at low pH (i.e., below approximately 6.0), 13 well-resolved, amide proton resonances are observed in the downfield region of an NMR spectrum (500 MHz).	Water	5-8	epidermal growth factor	Mus musculus	38-61
27074384-2	2016	In this study, total saponins (TS) from water extract of Kuding tea was prepared by D101 macroporous resins and analyzed by UPLC-QTOF-MS/MS.	Water	40-45	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	64-67
2988912-8	1985	These findings indicate that the renin-angiotensin system, in addition to effects on the sympathoadrenal system, regulates NaCl and water metabolism in birds with extrarenal salt glands.	Water	132-137	renin	Anas platyrhynchos	33-38
26976092-9	2016	All GPR40 receptor agonist GW9508, treatment groups enhanced the learning and memory ability in Step-through passive test, Morris water maze test, Hole board discrimination test, Novel object recognition test.	Water	130-135	free fatty acid receptor 1	Mus musculus	4-9
26960817-1	2016	The pH gating of human AQP3 and its effects on both water and glycerol permeabilities have been fully characterized for the first time using a human red blood cell model (hRBC).	Water	52-57	aquaporin 3 (Gill blood group)	Homo sapiens	23-27
4027237-10	1985	Acta 711, 386-390], inhibits LpL-catalyzed hydrolysis of PNPB, with Ki = 6.9 microM at pH 7.36, 25 degrees C. This result and the solvent isotope effects for LpL-catalyzed hydrolysis of water-soluble esters are interpreted in terms of a proton transfer mechanism that is similar in many respects to that of the serine proteases.	Water	186-191	lipoprotein lipase	Homo sapiens	29-32
4027237-10	1985	Acta 711, 386-390], inhibits LpL-catalyzed hydrolysis of PNPB, with Ki = 6.9 microM at pH 7.36, 25 degrees C. This result and the solvent isotope effects for LpL-catalyzed hydrolysis of water-soluble esters are interpreted in terms of a proton transfer mechanism that is similar in many respects to that of the serine proteases.	Water	186-191	lipoprotein lipase	Homo sapiens	158-161
2985582-0	1985	The C-6 proton of tetrahydrobiopterin is acquired from water, not NADPH, during de novo biosynthesis.	Water	55-60	complement C6	Bos taurus	4-7
26962099-10	2016	These findings suggest that metformin increases osmotic water permeability by increasing AQP2 accumulation in the apical plasma membrane but increases urea permeability by activating UT-A1 already present in the membrane.	Water	56-61	aquaporin 2	Rattus norvegicus	89-93
2985582-4	1985	Using these techniques, a gas chromatography/mass spectrometry method was developed to determine that in the biosynthesis of tetrahydrobiopterin de novo, in preparations of bovine adrenal medulla, the C-6 proton of tetrahydrobiopterin is derived from water and not from NADPH.	Water	251-256	complement C6	Bos taurus	201-204
27010030-2	2016	Inactivation of fmo-4, which encodes flavin-containing monooxygenase-4, results in dramatic hypoosmotic hypersensitivity; worms are unable to prevent overwhelming water influx and swell rapidly, finally rupturing due to high internal hydrostatic pressure.	Water	163-168	Dimethylaniline monooxygenase [N-oxide-forming]	Caenorhabditis elegans	16-21
27010030-4	2016	Thus, FMO-4 plays a crucial osmoregulatory role by promoting clearance of excess water that enters during hypotonicity, perhaps by synthesizing an osmolyte that acts to establish an osmotic gradient from excretory cell to duct and pore cells.	Water	81-86	Dimethylaniline monooxygenase [N-oxide-forming]	Caenorhabditis elegans	6-11
3987344-5	1985	The activity of phospholipase A2 (PLA2), an enzyme important for turnover of cellular phospholipids, was measured in the total water-insoluble fraction from whole lenses and from isolated lens regions by the release of 1-14C-linoleic acid from the number two position of a synthetic phosphatidylcholine.	Water	127-132	phospholipase A2 group IB	Rattus norvegicus	16-32
27229103-1	2016	Aquaporin 1(AQP1) and AQP5 have an important role in eliminating extravascular lung water, an increase of which contributes to lung injury in patients with sepsis and its consequent mortality.	Water	84-89	aquaporin 5	Homo sapiens	22-26
27167070-4	2016	Here we show that menadione (a water-soluble analog of vitamin K3) inhibits BP-induced expression and enzymatic activity of both CYP1A1 and CYP1A2 in vivo (in the rat liver) and BP-induced activity of CYP1A1 in vitro.	Water	31-36	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	129-135
3987344-5	1985	The activity of phospholipase A2 (PLA2), an enzyme important for turnover of cellular phospholipids, was measured in the total water-insoluble fraction from whole lenses and from isolated lens regions by the release of 1-14C-linoleic acid from the number two position of a synthetic phosphatidylcholine.	Water	127-132	phospholipase A2 group IB	Rattus norvegicus	34-38
2981549-7	1985	Since this method measures the concentration of Co2+ at the site of the fluorophore, it is generally applicable to the measurement of paramagnetic ion concentrations in the region of the membrane/water interface.	Water	196-201	complement C2	Homo sapiens	48-51
27155629-5	2016	The practical scaling of GPU-accelerated atomic orbital-based THC-SOS-MP2 calculations is found to be N(2.6) for reference data sets of water clusters and alanine polypeptides containing up to 1600 basis functions.	Water	136-141	tryptase pseudogene 1	Homo sapiens	70-73
3978077-5	1985	The Eu3+ bound at the catalytic site of pancreatic phospholipase A2 is coordinated to four or five water molecules, which, in conjunction with binding constant data, suggests the involvement of two or three protein ligands.	Water	99-104	LOC104974671	Bos taurus	51-67
27057921-2	2016	The photo- and thermally interconvertible planar E-1 and concaved Z-1 were found to exhibit different affinities, selectivities, and binding modes toward these biologically important anions in a highly polar medium (DMSO + 0.5% H2O).	Water	228-231	small nucleolar RNA, H/ACA box 73A	Homo sapiens	49-69
3978077-9	1985	In the phospholipase A2-Eu3+-micelle complex, only one H2O molecule is coordinated to Eu3+.	Water	55-58	LOC104974671	Bos taurus	7-23
26741353-10	2016	Additionally, unspliced-XBP1 increased with mineral-rich water.	Water	57-62	X-box binding protein 1	Rattus norvegicus	24-28
3978077-10	1985	This dehydration at the active site of phospholipase A2 in the protein-lipid complex can be an important reason for the enhanced activity of this enzyme at lipid-water interfaces.	Water	162-167	LOC104974671	Bos taurus	39-55
4034508-2	1985	The method is based on the osmotic transfer of water to a concentrated hydrophilic polymer (poly ethylene glycol, PEG) through a protein-stopping dialysis membrane and is a refinement of a method previously reported by van Oss.	Water	47-52	progestagen associated endometrial protein	Homo sapiens	114-117
27155427-9	2016	The highest relative expression of vitellogenin 1 (VTG1) was observed in tilapia from upstream, then the level significantly decreased along the water system.	Water	145-150	LOW QUALITY PROTEIN: vitellogenin-2	Oreochromis niloticus	35-49
27155427-9	2016	The highest relative expression of vitellogenin 1 (VTG1) was observed in tilapia from upstream, then the level significantly decreased along the water system.	Water	145-150	LOW QUALITY PROTEIN: vitellogenin-2	Oreochromis niloticus	51-55
6097223-2	1984	Bovine somatotropin with an increasing number of its carboxylate groups modified by reaction with glycine methyl ester in the presence of a water-soluble carbodi-imide was tested for its activity in different bioassays.	Water	140-145	somatotropin	Bos taurus	7-19
27061315-4	2016	Principal component analysis segregated SERS spectral features of tap water and milk samples with different melamine concentrations.	Water	70-75	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	40-44
26986971-8	2016	LC3 and AQPs have important roles for the survival of the brain under conditions of food and water deprivation, which provided further understanding of the mechanism underlying the "selfish brain" phenomenon.	Water	93-98	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	0-3
16593462-5	1984	It has a relatively short half-life (7 min at 9 degrees C); the chromophore is postulated to be the luciferase-bound flavin 4a-hydroxide and to decay to the stable product, FMN, by losing water.	Water	188-193	formin 1	Homo sapiens	173-176
26965091-1	2016	The Yellow Sea Cold Water Mass is a remarkable seasonal hydrographic event in the bottom water of the Yellow Sea.	Water	20-25	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	11-14
6700337-2	1984	V15 (nasal air flow related to 15 mm H2O) was registered.	Water	37-40	immunoglobulin lambda variable 2-18	Homo sapiens	0-3
26965091-1	2016	The Yellow Sea Cold Water Mass is a remarkable seasonal hydrographic event in the bottom water of the Yellow Sea.	Water	20-25	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
26965091-1	2016	The Yellow Sea Cold Water Mass is a remarkable seasonal hydrographic event in the bottom water of the Yellow Sea.	Water	89-94	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	11-14
26965091-1	2016	The Yellow Sea Cold Water Mass is a remarkable seasonal hydrographic event in the bottom water of the Yellow Sea.	Water	89-94	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
6499895-1	1984	The antihypertensive effect of moxonidine X HCl X H2O (MOX) was compared with that of clonidine X HCl (CLON) in a randomized double-blind crossover study in 20 hypertensive outpatients (BP range 154-178/96-108 mmHg).	Water	50-53	monooxygenase DBH like 1	Homo sapiens	55-58
27010847-3	2016	Analysis of the crystal CGL structures bound to galactose, galactosamine, and globotriose Gb3 indicated that each CGL can bind three ligands through a carbohydrate-binding motif involving an extensive histidine- and water-mediated hydrogen bond network.	Water	216-221	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	90-93
27073411-7	2016	This energy difference is reduced to 0.7 and 13.4 kcal/mol in water as a solvent using CPCM model using B3LYP/6-311 ++G** and MP2/6-311 ++G** level of theory, respectively.	Water	62-67	tryptase pseudogene 1	Homo sapiens	126-129
22054558-3	1984	The incidence of pale, soft and exudative (PSE) meat was identified by muscle colour and water holding capacity 24 h post mortem (C(24) and WHC(24)).	Water	89-94	PSE	Sus scrofa	43-46
26808975-11	2016	In conclusion, AQP3 does not simply function to transport water into and out of cells but also appears to be closely involved in development of the chicken oviduct, which is regulated by estrogens.	Water	58-63	aquaporin 3	Gallus gallus	15-19
26862153-3	2016	Using a split-root system to simulate a non-uniform root zone salinity in Gossypium hirsutum L., we showed that the up-regulated expression of sodium efflux-related genes (SOS1, SOS2, PMA1, and PMA2) and water uptake-related genes (PIP1 and PIP2) was possibly involved in the elevated Na(+) efflux and water use in the the roots in the non-saline side.	Water	204-209	sodium/hydrogen exchanger 8-like	Gossypium hirsutum	172-176
26862153-3	2016	Using a split-root system to simulate a non-uniform root zone salinity in Gossypium hirsutum L., we showed that the up-regulated expression of sodium efflux-related genes (SOS1, SOS2, PMA1, and PMA2) and water uptake-related genes (PIP1 and PIP2) was possibly involved in the elevated Na(+) efflux and water use in the the roots in the non-saline side.	Water	302-307	sodium/hydrogen exchanger 8-like	Gossypium hirsutum	172-176
6142880-2	1983	Resonance Raman (RR) spectra were obtained in H2O or D2O solution for the purple intermediates of D-amino acid oxidase (DAO) with isotopically labeled substrates, i.e., [1-13C]-, [2-13C]-, [3-13C]-, [15N]-, and [3,3,3-D3]alanine; [carboxyl-13C]- and [15N]proline.	Water	46-49	D-amino acid oxidase	Homo sapiens	98-118
27451751-0	2016	Synthesis and Upconversion Luminescence of Water-Soluble of GdF3:Yb3+/Er3+ Nanoparticles.	Water	43-48	growth differentiation factor 3	Homo sapiens	60-64
27451751-1	2016	Water-soluble Yb3+/Er3+ doped GdF3 nanocrystals were prepared using a thermal decomposition synthesis route.	Water	0-5	growth differentiation factor 3	Homo sapiens	30-34
27451751-3	2016	In Yb3+- and Er3+-codoped GdF3 nanocrystals, the relative intensity of green emission became stronger as the sample changed from water-soluble nanoparticles to hexane-dispersed nanoparticles.	Water	129-134	growth differentiation factor 3	Homo sapiens	26-30
6142880-2	1983	Resonance Raman (RR) spectra were obtained in H2O or D2O solution for the purple intermediates of D-amino acid oxidase (DAO) with isotopically labeled substrates, i.e., [1-13C]-, [2-13C]-, [3-13C]-, [15N]-, and [3,3,3-D3]alanine; [carboxyl-13C]- and [15N]proline.	Water	46-49	D-amino acid oxidase	Homo sapiens	120-123
6626981-6	1983	Chronic replacement with dexamethasone (DEX) offered in drinking water decreased the Hx-induced ODC response of ADX rats at 3 days after surgery to the level of enzyme activity observed in the S-ADX Hx subject.	Water	65-70	ornithine decarboxylase 1	Rattus norvegicus	96-99
26854667-0	2016	A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2.	Water	20-25	protein O-fucosyltransferase 2	Homo sapiens	63-93
26854667-5	2016	Site-directed mutagenesis demonstrates that POFUT2 fucosylates threonine preferentially over serine and relies on folded TSRs containing the minimal consensus sequence C-X-X-S/T-C. Crystallographic and mutagenesis data, together with atomic-level simulations, uncover a binding mechanism by which POFUT2 promiscuously recognizes the structural fingerprint of poorly homologous TSRs through a dynamic network of water-mediated interactions.	Water	411-416	protein O-fucosyltransferase 2	Homo sapiens	44-50
6199107-1	1983	The incidence of gamma-glutamyltranspeptidase (GGT)-positive foci induced by 0.3 mmol/kg diethylnitrosamine (DENA) followed by promotion with 500 ppm sodium phenobarbital in drinking water and was the same in Fischer 344, Sprague-Dawley and Wistar-Lewis rats.	Water	183-188	gamma-glutamyltransferase 1	Rattus norvegicus	47-50
26645545-7	2016	Acetone and diethylether followed by water also induced TLR4-dependent astrogliosis (GFAP upregulation) in spinal cord.	Water	37-42	glial fibrillary acidic protein	Mus musculus	85-89
6649997-7	1983	The quantity of waste water aboard a sea-going vessel including that from the toilets, washrooms, galley, and cleaning is rather considerable and is estimated at 300 litres per person and day under tropical climates.	Water	22-27	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	37-40
26931162-0	2016	A simple and sensitive flow injection method based on the catalytic activity of CdS quantum dots in an acidic permanganate chemiluminescence system for determination of formaldehyde in water and wastewater.	Water	185-190	CDP-diacylglycerol synthase 1	Homo sapiens	80-83
26841231-3	2016	In this work, we developed a synergistic ZnO/CdS/TiO2 hybrid, which could act as a robust and self-protected photocatalyst for water purification without additional sacrificial reagents.	Water	127-132	CDP-diacylglycerol synthase 1	Homo sapiens	45-48
6307354-1	1983	A water-soluble carbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, has been used to cross-link horse heart cytochrome c to spinach chloroplast plastocyanin.	Water	2-7	cytochrome c, somatic	Equus caballus	117-129
26768400-3	2016	The ion channel Kir4.1 plays an important role in the uptake of K(+) ions from the extracellular space and release of K(+) ions into the microvasculature, generating an osmotic gradient that drives water movement.	Water	198-203	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	16-22
6311329-3	1983	Substitution of 93% sea water for normal sea water produced a hyperpolarization of R15 which either silenced the cell or significantly increased the interburst interval in 9 out of 12 of the experiments.	Water	24-29	ribonuclease A family member 2	Rattus norvegicus	83-86
26894260-0	2016	Entrapment of Water at the Transmembrane Helix-Helix Interface of Quiescin Sulfhydryl Oxidase 2.	Water	14-19	quiescin sulfhydryl oxidase 2	Homo sapiens	75-95
6311329-3	1983	Substitution of 93% sea water for normal sea water produced a hyperpolarization of R15 which either silenced the cell or significantly increased the interburst interval in 9 out of 12 of the experiments.	Water	45-50	ribonuclease A family member 2	Rattus norvegicus	83-86
26843699-5	2016	In addition, BC/IGB composite produced by in situ method was compared with that produced by ex situ method, and the results shows that water holding capacity of BC/IGB composite obtained through in situ method was better.	Water	135-140	CD79b molecule	Homo sapiens	16-19
11596491-3	1983	After washing several times with distilled water, rapid freezing, and freeze-drying, the immobilized myosin molecules are visualized by shadow-casting at low temperature and at varying angles.	Water	43-48	myosin heavy chain 14	Homo sapiens	101-107
26843699-5	2016	In addition, BC/IGB composite produced by in situ method was compared with that produced by ex situ method, and the results shows that water holding capacity of BC/IGB composite obtained through in situ method was better.	Water	135-140	CD79b molecule	Homo sapiens	164-167
17815318-1	1983	Concurrent measurements of particle concentrations in the near-surface water and of particle fluxes in the deep water of the Sargasso Sea show a close coupling between the two for biogenic components.	Water	112-117	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	134-137
26805749-5	2016	Catalysis results from combination of both electrostatic stabilization reducing the negative electron density on the PO3(=) oxygens and monoester dianion destabilization by the steric effects of close NMe3(+) groups hindering the hydrogen-bonding with water and destabilising the monoester dianion.	Water	252-257	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	201-205
29991181-0	1983	A New Method for Simultaneous Measurement of Cl- , Br- , NO3- , SCN- , and I- at Sub-ppm Levels in Ground Water.	Water	106-111	citramalyl-CoA lyase	Homo sapiens	45-76
26901122-6	2016	Using the murine model of WNV disease, we find that inclusion of a TLR-4 agonist in either a stable oil-in-water emulsion (SE) or aluminum hydroxide (Alum) formulation provides both dose and dosage sparing functions, whereby protection can be induced after a single immunization containing only 100 ng of WN-80E.	Water	107-112	toll like receptor 4	Homo sapiens	67-72
26650818-5	2016	We found that the severity of EAU was significantly attenuated by MSCs; however, most therapeutic effects of MSCs were lost by pretreatment with a CD73 inhibitor.	Water	30-33	5' nucleotidase, ecto	Mus musculus	147-151
26674684-4	2016	Here we present INCA-Contaminants, the Integrated Catchments model for Contaminants; a new model that simultaneously and realistically solves mass balances of water, carbon, sediments and contaminants in the soil-stream-sediment system of catchments and their river networks as a function of climate, land use/management and contaminant properties.	Water	159-164	caspase recruitment domain family member 17	Homo sapiens	16-20
27107718-10	2016	We conclude a concomitant role for AQP11 with AQP4 in water efflux from these glial cells, which is disturbed in ERU.	Water	54-59	aquaporin 4	Equus caballus	46-50
6130536-8	1982	Knowledge of the rates of hydration and dehydration of CO2/HCO-3 in the fraction of the tissue water responsible for the H+-HCO-3 movements in many secretory epithelia is currently lacking.	Water	95-100	complement C2	Homo sapiens	55-64
26783632-7	2016	These SWCNTs-LB1 dispersions in water and cell media display near-infrared (NIR) absorption spectra with sharp van Hove peaks and an NIR fluorescence spectra, suggesting that LB1 individually disperses nanotubes.	Water	32-37	lamin B1	Homo sapiens	13-16
26783632-9	2016	The SWCNTs-LB1 dispersions with concentrations &gt;=150 mug/mL (&gt;=30 mug/mL) in water (cell media) remain stable for &gt;=75 days (&gt;=3 days) at 4  C (37  C).	Water	83-88	lamin B1	Homo sapiens	11-14
6291408-2	1982	After 25 microunits/ml ADH (n=8) in the presence of 1.25 mM calcium bath, water flow (Jv) rose to 1.56 +/- 0.34 nl.mm-1.	Water	74-79	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	23-26
26716352-0	2016	Spectroscopic and Crystallographic Evidence for the Role of a Water-Containing H-Bond Network in Oxidase Activity of an Engineered Myoglobin.	Water	62-67	myoglobin	Homo sapiens	131-140
27389220-0	2016	The nature of the CO2 (-) radical anion in water.	Water	43-48	complement C2	Homo sapiens	18-21
27389224-2	2016	In particular, we calculate the vertical detachment energy of an excess electron from water cluster anions with methods that include one-electron pseudopotential calculations, density functional theory(DFT) based calculations, and ab initio quantum chemistry using MP2 and eom-EA-CCSD levels of theory.	Water	86-91	tryptase pseudogene 1	Homo sapiens	265-268
7167403-3	1982	Boiling water extracts of pyloric antrum cross reacted with four antisera specific for the C-terminal region of gastrin or CCK, but estimates of concentration varied between antisera.	Water	8-13	gastrin	Homo sapiens	112-119
26566708-4	2016	We prospectively investigated the associations between HO-1 (GT)n polymorphism and cancer risk related to arsenic from drinking water.	Water	128-133	heme oxygenase 1	Homo sapiens	55-59
26839969-3	2016	A polysaccharides depleted-water extract of P. lactiflora (PL-PP) increased LIF expression in human endometrial Ishikawa cells at non-cytotoxic doses.	Water	27-32	LIF interleukin 6 family cytokine	Homo sapiens	76-79
7144745-1	1982	Affinity partitioning in dextran-polyethylene glycol-water biphasic systems has demonstrated that myosin has hydrophobic surface properties.	Water	53-58	myosin heavy chain 14	Homo sapiens	98-104
26612101-4	2016	Maximal Twitch PDI responses were progressively reduced in patients with LOPD compared to control subjects (1.4-17.1cm H2O, p&lt;0.001) and correlated to voluntary functional tests (p&lt;0.05).	Water	119-122	peptidyl arginine deiminase 1	Homo sapiens	15-18
27081066-2	2016	The inelastic scattering cross section was resonantly enhanced by "gating" the frontier orbitals of water via a chlorine-terminated tip, so the hydrogen-bonding strength can be determined with high accuracy from the red shift in the oxygen-hydrogen stretching frequency of water.	Water	273-278	TOR signaling pathway regulator	Homo sapiens	132-135
26651152-2	2016	Here, we report the development of a CuO/Silicon based photoanode, which shows an onset potential for the water oxidation of 0.53 V vs SCE at pH 9, that is, an overpotential of 75 mV, and high stability above 10 h. These values account for a photovoltage of 420 mV due to the absorbed photons by silicon, as proven by comparing with analogous CuO/FTO electrodes that are not photoactive.	Water	106-111	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	347-350
26983853-1	2016	Water-dispersible upconversion nanoparticles (beta-NaYF4:Yb(3+),Er(3+), UCNP) coated with a thin shell of a biocompatible copolymer comprising 2-hydroxyethylmethacrylate (HEMA) and 2-acrylamido-2-methyl-1-propanesulphonsulphonic acid (AMPS), which we will term COP, have been prepared by multidentate grafting.	Water	0-5	caspase recruitment domain family member 16	Homo sapiens	261-264
7138835-13	1982	The data show that two water molecules are bound in the first coordination sphere of Mn2+ in the active site of glyoxalase I.	Water	23-28	glyoxalase I	Homo sapiens	112-124
27052448-5	2016	RESULTS: The treatment of SMGGT water extract significantly inhibited the production of MMP-1 and promoted type-1 procollagen synthesis concentration dependently.	Water	32-37	matrix metallopeptidase 1	Homo sapiens	88-93
26652192-4	2016	The surface-modified membrane, when used with chloroform-based solvent, exhibited superb permeate flux, breakthrough pressure, and also separation yield: it allowed separation of 95.5 +- 1.2% of converted lipid (FAME) in the chloroform phase from the water/MeOH phase with microalgal debris.	Water	251-256	benign adult familial myoclonic epilepsy 1	Homo sapiens	212-216
7138835-15	1982	An enediol mechanism involving the metal-bound water is proposed for the catalysis effected by glyoxalase I.	Water	47-52	glyoxalase I	Homo sapiens	95-107
26196932-5	2016	The sensor RBP was preliminarily applied to the determination of Al(3+) in water samples from the lake of Henan University and tap water with satisfying results.	Water	131-136	SURP and G-patch domain containing 1	Homo sapiens	11-14
6807983-2	1982	During the hydrolysis of MgATP by myosin, there is an extensive exchange of oxygen between water and the terminal phosphate group of bound nucleotide, which results from a repeated cycle of hydrolytic cleavage and its reversal.	Water	91-96	myosin heavy chain 14	Homo sapiens	34-40
26540606-3	2016	In this study, we examined the neuroprotective effects of these water-soluble FA derivatives on Abeta-induced neurodegeneration both in vitro and in vivo.	Water	64-69	amyloid beta (A4) precursor protein	Mus musculus	96-101
26540606-4	2016	FA and water-soluble FA derivatives inhibited Abeta aggregation and destabilized pre-aggregated Abeta to a similar extent.	Water	7-12	amyloid beta (A4) precursor protein	Mus musculus	46-51
26912321-6	2016	Finally, blocking HVEM cosignals by antagonistic anti-HVEM Abs ameliorated EAU.	Water	75-78	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	Mus musculus	18-22
26912321-6	2016	Finally, blocking HVEM cosignals by antagonistic anti-HVEM Abs ameliorated EAU.	Water	75-78	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	Mus musculus	54-58
26912321-7	2016	Taken together, our studies revealed a novel function of the HVEM cosignaling molecule and its ligands in EAU pathogenesis through the induction of Th1- and Th17-type T cell responses and suggested that HVEM-related molecular pathways can be therapeutic targets in autoimmune uveitis.	Water	106-109	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	Mus musculus	61-65
26912321-7	2016	Taken together, our studies revealed a novel function of the HVEM cosignaling molecule and its ligands in EAU pathogenesis through the induction of Th1- and Th17-type T cell responses and suggested that HVEM-related molecular pathways can be therapeutic targets in autoimmune uveitis.	Water	106-109	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	Mus musculus	203-207
26540606-5	2016	Furthermore, water-soluble FA derivatives, as well as FA, inhibited Abeta-induced neuronal cell death in cultured neuronal cells.	Water	13-18	amyloid beta (A4) precursor protein	Mus musculus	68-73
26540606-6	2016	In in vivo experiments, oral administration of water-soluble FA derivatives to mice improved Abeta-induced dysmnesia assessed by contextual fear conditioning test and protected hippocampal neurons against Abeta-induced neurotoxicity.	Water	47-52	amyloid beta (A4) precursor protein	Mus musculus	93-98
6181786-0	1982	Nascent alpha 2-macroglobulin-trypsin complex: incorporation of amines and water at the thiol esterified Glx-residues of alpha 2-macroglobulin during activation with trypsin.	Water	75-80	alpha-2-macroglobulin	Homo sapiens	8-29
26844893-4	2016	In addition to its role for the SC structural and mechanical integrity, FLG degradation products account in part for the water-holding capacity and maintenance of acidic pH of the SC, both crucial for the epidermal barrier homoeostasis by regulating activity of multiple enzymes that control desquamation, lipid synthesis and inflammation.	Water	121-126	filaggrin	Homo sapiens	72-75
26881185-1	2016	A water-soluble fluorescent probe (C-GGH) was used for the highly sensitive and selective detection of cyanide (CN(-)) in aqueous media based on the displacement strategy.	Water	2-7	gamma-glutamyl hydrolase	Homo sapiens	37-40
26537593-3	2016	First, the involvement of AQP5 in water secretion from acinar cells was demonstrated by measuring volume changes of acini/acinar cells, as well as activation energy (E a) in transepithelial water movement by NMR spectrometry, and a functional linkage between AQP5 and TRPV4 was suggested.	Water	34-39	aquaporin 5	Homo sapiens	26-30
6181786-0	1982	Nascent alpha 2-macroglobulin-trypsin complex: incorporation of amines and water at the thiol esterified Glx-residues of alpha 2-macroglobulin during activation with trypsin.	Water	75-80	alpha-2-macroglobulin	Homo sapiens	121-142
26537593-3	2016	First, the involvement of AQP5 in water secretion from acinar cells was demonstrated by measuring volume changes of acini/acinar cells, as well as activation energy (E a) in transepithelial water movement by NMR spectrometry, and a functional linkage between AQP5 and TRPV4 was suggested.	Water	190-195	aquaporin 5	Homo sapiens	26-30
7046164-7	1982	In addition to potent in vitro immunosuppressive properties, supplementation of drinking water with BA or PA resulted in prolongation of full-thickness skin grafts in DBA/2 (H-2d) to C57BL/6 (H-2b) donor-recipient combinations.	Water	89-94	H2B clustered histone 21	Homo sapiens	192-196
26915667-1	2016	The adsorption of surfactants (DTAB, SDS, and CAPB) at the calcite-water interface was studied through surface zeta potential measurements and multiscale molecular dynamics.	Water	67-72	EPH receptor B2	Homo sapiens	46-50
26699931-2	2016	The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression.	Water	49-54	steroidogenic acute regulatory protein	Danio rerio	175-213
26699931-2	2016	The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression.	Water	49-54	steroidogenic acute regulatory protein	Danio rerio	215-219
26699931-2	2016	The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression.	Water	49-54	heat shock protein 8-like	Danio rerio	226-247
26699931-2	2016	The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression.	Water	49-54	heat shock protein 8-like	Danio rerio	249-254
26699931-2	2016	The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression.	Water	49-54	steroidogenic acute regulatory protein	Danio rerio	402-406
26699931-2	2016	The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression.	Water	49-54	heat shock protein 8-like	Danio rerio	411-416
24271910-6	1982	These data support the role of ceruloplasmin as an antioxidant that prevents the formation of the intermediate active oxygen species O 2 (-)   and H2O 2 ( ) through the Fe(II) auto-oxidation reaction.A hitherto unrecognized factor in the control of nonenzymic oxidation of Fe(II) was serum albumin.	Water	147-150	ceruloplasmin	Homo sapiens	31-44
27494159-6	2016	Activation of the intestinal opioid receptors (ORs), in particular mu (MOP) and delta (DOP) results in reduction of epithelial secretion and increase of water/electrolyte absorption; moreover, opioids are strong analgesic agents.	Water	153-158	opioid receptor mu 1	Homo sapiens	71-74
26720327-3	2016	It is shown that 20 mg of SBA/SA or SBA/EnSA can remove rapidly (~15 min) and quantitatively uranium(VI) ions from 10 to 200 mL of water solutions (pH 4) containing 0.2 mg of the ions, at 25  C. The adsorbed ions were stripped by 1 mL of dilute nitric acid solution (0.1 mol L(-1)).	Water	131-136	endosulfine alpha	Homo sapiens	40-44
6275889-6	1982	NADH oxidation, both in intact and in water-treated mitochondria, is 90% inhibited by mersalyl, an inhibitor of the outer membrane NADH-cytochrome b5 reductase, and 10% inhibited by rotenone.	Water	38-43	cytochrome b5 type A	Homo sapiens	136-149
27437529-4	2015	The main objective of WASH - (Water supply, Sanitation and Hygenie promotion) programmes in disasters is to reduce the transmission of faeco-oral diseases and exposure to disease-bearing vectors through the promotion of: good hygiene practices, the provision of safe drinking water, the reduction of environmental health risks, the conditions that allow people to a healthy life with dignity, comfort and security.	Water	276-281	WASP family homolog 6, pseudogene	Homo sapiens	22-26
26672976-5	2016	Similar to the corresponding alpha-Keggin-type derivatives, both alpha1-RuH2O and alpha2-RuH2O show catalytic activity for water oxidation.	Water	123-128	adrenoceptor alpha 1D	Homo sapiens	65-71
26852340-6	2016	Four of the glycine water-soluble AAPCs (16, 18, 44 and 45) showed quantitative cleavage by LAP, resulting in the release of the highly cytotoxic parent drug, whereas partial cleavage (&lt;10-90%) was observed for other prodrugs (15, 17, 24, 38 and 39).	Water	20-25	LAP	Homo sapiens	92-95
26747210-1	2016	Aquaporin (AQP) 7 and AQP9 are subcategorised as aquaglyceroporins which transport glycerin in addition to water.	Water	107-112	aquaporin 7	Mus musculus	0-17
26747210-1	2016	Aquaporin (AQP) 7 and AQP9 are subcategorised as aquaglyceroporins which transport glycerin in addition to water.	Water	107-112	aquaporin 9	Mus musculus	22-26
27057285-9	2016	After 6 weeks, AP39 administration to APP/PS1 mice significantly ameliorated their spatial memory deficits in the Morris water maze and NORT and reduced Abeta deposition in their brains.	Water	121-126	presenilin 1	Mus musculus	42-45
6287818-1	1982	Water soluble analogs of British Anti-Lewisite that are active orally and less toxic than BAL are now available.	Water	0-5	poly (ADP-ribose) polymerase family, member 9	Mus musculus	90-93
26522287-0	2016	Molecular dynamics of water and monovalent-ions transportation mechanisms of pentameric sarcolipin.	Water	22-27	sarcolipin	Homo sapiens	88-98
6128104-15	1982	It is concluded that an apparently uneventful swallowing of sea water can turn into secondary drowning with transient acute renal failure.	Water	64-69	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	60-63
26831602-12	2016	The mean real-time maximum pain scores during insertion 2.9 +- 2.1 for CO2, 2.7 +- 1.9 for water achieved a significantly lower pain score compared with air (5.7 +- 2.5) group (air vs CO2 P &lt; 0.001; air vs water P &lt; 0.001).	Water	209-214	complement C2	Homo sapiens	71-74
6275285-3	1981	In contrast, substitution of drinking water by a solution containing 20 microgram/ml dexamethasone for 5 days produced a significant increase in the neurointermediate pituitary content of ir-DYN, ir-1-ENK and ir-VP, whereas levels of ir-beta-END remained unaffected.	Water	38-43	proenkephalin	Rattus norvegicus	201-204
27405172-14	2016	Meanwhile, decoction prepared by tap water should be taken by patients in a short time.	Water	37-42	filamin B	Homo sapiens	33-36
6266299-1	1981	Increased concentrations of angiotensin converting enzyme (ACE) were found in lung lavages from rabbits exposed to hyperoxia for 72 h and the concentrations of ACE were correlated with ratios of extravascular lung water to body weight (r = 0.69, p less than 0.05) and albumin concentrations in lung lavages (r = 0.89, p less than 0.01).	Water	214-219	angiotensin-converting enzyme	Oryctolagus cuniculus	28-57
6789903-19	1981	This model has the attraction that it explains the magnetic relaxation rate of solvent water protons in the Co2+-substituted enzyme, whereas the hydroxide mechanism cannot explain these data without the introduction of unfounded ad hoc assumptions; further, the presence of an OH- ligand of the metal has never been demonstrated.	Water	87-92	complement C2	Homo sapiens	108-111
26634958-6	2015	Furthermore, in the earlier stage of ArgP1 access to the pocket, we observed that ArgP1 was spatially separated from Asp189 by two water molecules in the pocket.	Water	131-136	diacylglycerol O-acyltransferase 1	Homo sapiens	37-42
26634958-6	2015	Furthermore, in the earlier stage of ArgP1 access to the pocket, we observed that ArgP1 was spatially separated from Asp189 by two water molecules in the pocket.	Water	131-136	diacylglycerol O-acyltransferase 1	Homo sapiens	82-87
6270851-2	1981	Cortisol-21-hemisuccinate was conjugated with beta-galactosidase using a water-soluble carbodiimide.	Water	73-78	galactosidase beta 1	Bos taurus	46-64
26714855-0	2015	Partial nephrogenic diabetes insipidus caused by a novel AQP2 variation impairing trafficking of the aquaporin-2 water channel.	Water	113-118	aquaporin 2	Canis lupus familiaris	57-61
6941288-3	1981	In water (eta = 1 centipoise or 1 x 10(-3) Pa .	Water	3-8	secreted phosphoprotein 1	Homo sapiens	10-17
26514291-1	2015	Long-circulating liposomes (LCL) are often used as a drug carrier system to improve the therapeutic index of water-soluble drugs.	Water	109-114	lens cloudy	Mus musculus	28-31
6269517-1	1981	The relationship between the activities of both pyrimidine 5"-nucleotidase (Py5N) and delta-aminolevulinate dehydratase (ALA-D) in erythrocytes and the concentration of lead in blood was investigated in the mice which were given ad libitum a drinking water containing lead of 10 to 500 ppm, for 30 days.	Water	251-256	aminolevulinate, delta-, dehydratase	Mus musculus	121-126
26687436-7	2015	We conclude that this method can be used to explore the extraction behaviour and efficiency of some ions or molecules that enhance the SERS intensity in water or oil by inducing nanoparticle aggregation.	Water	153-158	seryl-tRNA synthetase 1	Homo sapiens	135-139
7228441-0	1981	Body water metabolism in high altitude natives during and after a stay at sea level.	Water	5-10	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	74-77
26480815-2	2015	Dysregulation of AQP4 is critically associated with abnormal water transport in the astrocytes.	Water	61-66	aquaporin 4	Rattus norvegicus	17-21
7314081-0	1981	Chemical and biological properties of subfractions of hot-water extract from delipidated BCG.	Water	58-63	alcohol dehydrogenase, iron containing, 1	Mus musculus	54-57
26485141-7	2015	Sodium arsenite at a dose of 40 mg/L supplied via drinking water in mice significantly raised the serum level of liver function markers such as AST, ALT, and ALP, and caused arsenic deposition in liver and ROS generation, though it did not show any lethality up to 30 days of exposure.	Water	59-64	glutamic pyruvic transaminase, soluble	Mus musculus	149-152
26545372-7	2015	The sea level rise would decrease fecal coliform distributions because both the water level and the water volume increased.	Water	80-85	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	4-7
26545372-7	2015	The sea level rise would decrease fecal coliform distributions because both the water level and the water volume increased.	Water	100-105	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	4-7
7314081-6	1981	These results suggest that the hot-water extract from delipidated BCG consists of subfractions with different chemical and biological properties.	Water	35-40	alcohol dehydrogenase, iron containing, 1	Mus musculus	31-34
7202411-2	1981	Carboxylase groups in bovine pancreatic phospholipase A2 were modified using a water-soluble carbodiimide and semicarbazide.	Water	79-84	LOC104974671	Bos taurus	40-56
6165917-3	1980	Lumbar tap revealed clear CSF under normal pressure of 110 mm H2O with the CSF protein of 432.5 mg/dl and cell count of 147/3.	Water	62-65	colony stimulating factor 2	Homo sapiens	26-29
26499938-3	2015	The better crystallinity at a larger domain size ensures excellent PEC water splitting performance, leading to record high photocurrent from pure planar hematite thin films on FTO substrates.	Water	71-76	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	176-179
26462065-7	2015	Taking advantages of high specificity and sensitivity of the probe as well as its good water-solubility, biocompatibility, and cell membrane permeability, PTTA-Tb(3+)@AFt-Rh-NO was successfully used for the luminescent imaging of NO in living cells and Daphnia magna.	Water	87-92	ferritin heavy chain 1	Homo sapiens	167-170
26578982-12	2015	The increase in AQP2 activity promotes water reabsorption, which may contribute to glucocorticoid-induced water retention and hypertension.	Water	39-44	aquaporin 2	Homo sapiens	16-20
25990584-1	2015	The study showed that the open water of the Bothnian Sea (BS) is likely to have shifted from altering nitrogen and phosphorous limitations of the spring bloom to more nitrogen-limited conditions during the last 20 years.	Water	31-36	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	53-56
26497451-5	2016	Good inactivation of MS2 (&gt;6-log inactivation after exposure to a total fluence of 1.34 kJ/cm(2)) was achieved in Swiss tap water at 22 C, while less-efficient inactivation was observed in Indian waters and for echovirus (1.5-log inactivation at the same fluence).	Water	127-132	MS2	Homo sapiens	21-24
26497451-7	2016	High temperatures enhanced MS2 inactivation substantially; at 40 C, 3-log inactivation was achieved in Swiss tap water after exposure to a fluence of only 0.18 kJ/cm(2).	Water	113-118	MS2	Homo sapiens	27-30
26311303-0	2015	A sea anemone-like CuO/Co3O4 composite: an effective catalyst for electrochemical water splitting.	Water	82-87	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	2-5
26311303-1	2015	A facile unipolar pulse electrodeposition combined with the thermal oxidation method was applied for fabrication of CuO/Co3O4 composites on carbon electrode for water electrolysis, and it was found that the sea anemone-like one with a 3D hierarchical structure formed at -0.8 V exhibited excellent performance for water electrolysis at a low overpotential with high stability.	Water	161-166	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	207-210
26311303-1	2015	A facile unipolar pulse electrodeposition combined with the thermal oxidation method was applied for fabrication of CuO/Co3O4 composites on carbon electrode for water electrolysis, and it was found that the sea anemone-like one with a 3D hierarchical structure formed at -0.8 V exhibited excellent performance for water electrolysis at a low overpotential with high stability.	Water	314-319	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	207-210
26234614-5	2015	These results imply that the bloom was transported with the low salinity water from the Ariake Sea to Tachibana Bay.	Water	73-78	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	95-98
26234614-7	2015	Low salinity water intrusion induced an interregional difference of the Chattonella and Skeletonema bloom spatially-differentiated by the salinity in the Ariake Sea and Tachibana Bay.	Water	13-18	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	161-164
25603318-1	2015	In this study the putative protective seroprevalence (PPS) of IgG antibodies to the 27-kDa and 15/17-kDa Cryptosporidium antigens in sera of healthy participants who were and were not exposed to Cryptosporidium oocysts via surface water-derived drinking water was compared.	Water	231-236	inositol polyphosphate-5-phosphatase K	Homo sapiens	54-57
25603318-1	2015	In this study the putative protective seroprevalence (PPS) of IgG antibodies to the 27-kDa and 15/17-kDa Cryptosporidium antigens in sera of healthy participants who were and were not exposed to Cryptosporidium oocysts via surface water-derived drinking water was compared.	Water	254-259	inositol polyphosphate-5-phosphatase K	Homo sapiens	54-57
25603318-3	2015	The PPS was significantly greater (49-61%) in settlements where the drinking water originated from surface water, than in the control city where riverbank filtration was used (21% and 23%).	Water	77-82	inositol polyphosphate-5-phosphatase K	Homo sapiens	4-7
25603318-3	2015	The PPS was significantly greater (49-61%) in settlements where the drinking water originated from surface water, than in the control city where riverbank filtration was used (21% and 23%).	Water	107-112	inositol polyphosphate-5-phosphatase K	Homo sapiens	4-7
26159101-8	2015	There was an association between CSFp and FPG at baseline: CSFp was more elevated in subjects with high FPG (378 +- 90 mm H2O, n = 50) than in subjects with low FPG (331 +- 77, n = 115, p = 0.002).	Water	122-125	colony stimulating factor 2	Homo sapiens	59-63
26351734-6	2015	Here we present an MD simulation analysis of a powder hydrated at 0.4 g water/g protein of the IDP tau in the temperature range 20-300 K. By comparing with neutron scattering data, we identify the protein-water interface as the predominant feature determining IDP dynamics.	Water	72-77	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	95-98
26351734-6	2015	Here we present an MD simulation analysis of a powder hydrated at 0.4 g water/g protein of the IDP tau in the temperature range 20-300 K. By comparing with neutron scattering data, we identify the protein-water interface as the predominant feature determining IDP dynamics.	Water	205-210	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	95-98
26351734-6	2015	Here we present an MD simulation analysis of a powder hydrated at 0.4 g water/g protein of the IDP tau in the temperature range 20-300 K. By comparing with neutron scattering data, we identify the protein-water interface as the predominant feature determining IDP dynamics.	Water	205-210	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	260-263
26324257-6	2015	Under environmental conditions a layer of water or hydrocarbon often forms between the probe tip and sample.	Water	42-47	TOR signaling pathway regulator	Homo sapiens	93-96
26215784-6	2015	Chronic treatment with m266 resulted in a ~70-fold increase in Abeta detected in the bloodstream, and a ~50% increase in water-soluble brain Abeta--and in both cases Abeta was bound to m266.	Water	121-126	amyloid beta (A4) precursor protein	Mus musculus	141-146
26215784-6	2015	Chronic treatment with m266 resulted in a ~70-fold increase in Abeta detected in the bloodstream, and a ~50% increase in water-soluble brain Abeta--and in both cases Abeta was bound to m266.	Water	121-126	amyloid beta (A4) precursor protein	Mus musculus	141-146
26116783-3	2015	In addition, studies indicated the involvement of NUCB2/nesfatin-1 in other homeostatic functions as well: glucose homeostasis, water intake, gastrointestinal functions, temperature regulation, cardiovascular functions, puberty onset and sleep.	Water	128-133	nucleobindin 2	Homo sapiens	50-55
26116783-3	2015	In addition, studies indicated the involvement of NUCB2/nesfatin-1 in other homeostatic functions as well: glucose homeostasis, water intake, gastrointestinal functions, temperature regulation, cardiovascular functions, puberty onset and sleep.	Water	128-133	nucleobindin 2	Homo sapiens	56-66
26220686-7	2015	The interaction between CYBA rs3794624 and well water As on annual PP remained statistically significant after correction for multiple comparisons (FDR-adjusted p for interaction=0.05).	Water	48-53	cytochrome b-245 alpha chain	Homo sapiens	24-28
26424896-12	2015	Therefore, TRPV4-AQP4 interactions constitute a molecular system that fine-tunes astroglial volume regulation by integrating osmosensing, calcium signaling, and water transport and, when overactivated, triggers pathological swelling.	Water	161-166	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	11-16
26424896-13	2015	Significance statement: We characterize the physiological features of interactions between the astroglial swelling sensor transient receptor potential isoform 4 (TRPV4) and the aquaporin 4 (AQP4) water channel in retinal Muller cells.	Water	196-201	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	162-167
26424896-15	2015	Specifically, water influx through AQP4 drives calcium influx via TRPV4 in the glial end foot, which regulates expression of Aqp4 and Kir4.1 genes and facilitates the time course and amplitude of hypotonicity-induced swelling and regulatory volume decrease.	Water	14-19	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	66-71
26403195-3	2015	Here we demonstrate that sea-level rise will result in larger waves and higher wave-driven water levels along atoll islands" shorelines than at present.	Water	91-96	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	25-28
26403195-4	2015	Numerical model results reveal waves will synergistically interact with sea-level rise, causing twice as much land forecast to be flooded for a given value of sea-level rise than currently predicted by current models that do not take wave-driven water levels into account.	Water	246-251	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	72-75
29124204-3	2015	Mitochondrial AQP8 with permeability for water, H2O2 and NH3 has been expected to have important role in various cells, but its information is limited to a few tissues and cells including liver and kidney.	Water	41-46	aquaporin 8	Mus musculus	14-18
29124204-13	2015	General significance: The AQP8-knocked down cells we established provides a model system for the studies on the relationships between water homeostasis and mitochondrial function.	Water	134-139	aquaporin 8	Mus musculus	26-30
25588806-6	2015	AtPED2 also positively regulated drought stress resistance, as evidenced by the changes of water loss rate, electrolyte leakage, and survival rate.	Water	91-96	peroxin 14	Arabidopsis thaliana	0-6
26255305-2	2015	dMRI is a non-invasive imaging methodology in which image contrast is based on the diffusion of water molecules in tissue.	Water	96-101	mrityu	Drosophila melanogaster	0-4
26021845-0	2015	Silicon improves salt tolerance by increasing root water uptake in Cucumis sativus L. KEY MESSAGE: Silicon enhances root water uptake in salt-stressed cucumber plants through up-regulating aquaporin gene expression.	Water	121-126	Probable aquaporin PIP1-4-like	Cucumis sativus	189-198
26021845-8	2015	Expressions of main plasma membrane aquaporin genes in roots were increased by added silicon, and the involvement of aquaporins in water uptake was supported by application of aquaporin inhibitor and restorative.	Water	131-136	Probable aquaporin PIP1-4-like	Cucumis sativus	117-126
26021845-10	2015	Our results suggest that silicon can improve salt tolerance of cucumber plants through enhancing root water uptake, and silicon-mediated up-regulation of aquaporin gene expression may in part contribute to the increase in water uptake.	Water	222-227	Probable aquaporin PIP1-4-like	Cucumis sativus	154-163
26541434-9	2016	The expression of miR-223 and miR-146a corresponded with the clinical score of the EAU and elevation of IL-1beta/MCP-1 in the eye with EAU.	Water	83-86	microRNA 223	Rattus norvegicus	18-25
26541434-9	2016	The expression of miR-223 and miR-146a corresponded with the clinical score of the EAU and elevation of IL-1beta/MCP-1 in the eye with EAU.	Water	83-86	microRNA 146a	Rattus norvegicus	30-38
29899902-0	2016	Metal-organic framework-based CoP/reduced graphene oxide: high-performance bifunctional electrocatalyst for overall water splitting.	Water	116-121	caspase recruitment domain family member 16	Homo sapiens	30-33
26849047-4	2016	Of 21 antibiotics, only florfenicol and thiamphenicol were found in tap water, with the median concentrations of 0.0089 ng/mL and 0.0064 ng/mL, respectively; only florfenicol was found in three bottled water samples from a same brand, with the concentrations ranging from 0.00060 to 0.0010 ng/mL; no antibiotics were found in barreled water.	Water	72-77	filamin B	Homo sapiens	68-71
26585348-1	2016	Water soluble perylenediimide based fluorophore salt, N,N"-bis(ethelenetrimethyl ammoniumiodide)-perylene-3,4,9,10-tetracarboxylicbisimide (PDI-1), has been used for selective fluorescence sensing of picric acid (PA) and 4-nitroaniline (4-NA) in organic as well as aqueous medium across wide pH range (1.0 to 10.0).	Water	0-5	peptidyl arginine deiminase 1	Homo sapiens	140-145
26777423-4	2016	Transgenic mouse models expressing connexin26 KID mutations reproduce human phenotypes and present impaired epidermal calcium homeostasis and abnormal lipid composition of the stratum corneum affecting the water barrier.	Water	206-211	gap junction protein, beta 2	Mus musculus	35-45
26670094-6	2016	In addition, ApoJ treatment was shown to suppress the inflammatory response (glial activation, cytokine expression), blood-brain barrier disruption (Evans blue extravasation), and cerebral edema (water content) induced by CCI.	Water	196-201	clusterin	Mus musculus	13-17
26931703-1	2016	Non-covalent interaction of acetic acid (AA) and water is studied experimentally by IR spectroscopy in a nitrogen matrix and theoretically at the MP2 and coupled-cluster with single and double and perturbative triple excitations [CCSD(T)]/6-311++G(2d,2p) levels of theory.	Water	49-54	tryptase pseudogene 1	Homo sapiens	146-149
26806311-8	2016	The upper pKa reflects the ionization of the metal-bound water molecule and shifts to 9.1 in Zn(II)-HDAC8.	Water	57-62	histone deacetylase 8	Homo sapiens	100-105
26860894-9	2016	XCT as a nondestructive method for sub-surface tomographic imaging holds promise for several applications in semiconductor metrology and imaging in the water window.	Water	152-157	solute carrier family 7 member 11	Homo sapiens	0-3
26748890-3	2016	Here, based on a crystal structure of Sirt2 in complex with an optimized sirtuin rearranging ligand (SirReal) that shows improved potency, water solubility, and cellular efficacy, we present the development of the first Sirt2-selective affinity probe.	Water	139-144	sirtuin 2	Homo sapiens	38-43
26748890-3	2016	Here, based on a crystal structure of Sirt2 in complex with an optimized sirtuin rearranging ligand (SirReal) that shows improved potency, water solubility, and cellular efficacy, we present the development of the first Sirt2-selective affinity probe.	Water	139-144	sirtuin 2	Homo sapiens	220-225
26687814-8	2016	In contrast, perinatal tau and tau in cold water-stressed mice were all phosphorylated with a similar extent of phosphorylation.	Water	43-48	microtubule associated protein tau	Homo sapiens	23-26
26687814-8	2016	In contrast, perinatal tau and tau in cold water-stressed mice were all phosphorylated with a similar extent of phosphorylation.	Water	43-48	microtubule associated protein tau	Homo sapiens	31-34
27215121-0	2016	[THE EFFECT OF 5 DAYS IMMERSION IN DEAD SEA WATER ON BLOOD GLUCOSE LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS].	Water	44-49	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	40-43
27215121-2	2016	In a previous pilot study, a significant reduction in blood glucose levels among diabetes mellitus (DM) patients was found following a single immersion in Dead Sea water but not after immersion in plain water.	Water	164-169	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	160-163
27215121-7	2016	RESULTS: Blood glucose levels significantly decreased immediately after immersion both in Dead Sea water and plain water compared to their values prior to immersion (p&lt;0.001).	Water	99-104	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	95-98
27215121-9	2016	A decrease in fasting glucose levels was observed only in the group immersed in Dead Sea water when compared to plain water (6.83+-5.68 mg/dl versus 4.37+-1.79 respectively and the difference was close to statistical significance (p=0.071.	Water	89-94	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
27215121-11	2016	CONCLUSION: Immersion for 20 minutes in water (Dead Sea or plain water) at a temperature of 35 C induced an immediate reduction in glucose levels in patients with type 2 DM.	Water	40-45	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	52-55
26198257-8	2015	These findings suggest that CIPK21 mediates responses to salt stress condition in Arabidopsis, at least in part, by regulating ion and water homeostasis across the vacuolar membranes.	Water	135-140	CBL-interacting protein kinase 21	Arabidopsis thaliana	28-34
26204389-2	2015	Undissociated volatile acid eluites (e.g., H2S, HCN, H2CO3, etc., represented as HA) transfer through the membrane and react as OH(-) + HA   A(-) + H2O; the conversion of high-mobility OH(-) to lower mobility A(-) results in a significant negative response for these analytes.	Water	148-151	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	48-51
26698132-6	2016	In the case of high temperature-annealed photoanodes, Sn leaching (resulting from FTO deformation) also affected the water oxidation performance of the photoanodes.	Water	117-122	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	82-85
6165917-3	1980	Lumbar tap revealed clear CSF under normal pressure of 110 mm H2O with the CSF protein of 432.5 mg/dl and cell count of 147/3.	Water	62-65	colony stimulating factor 2	Homo sapiens	75-78
7356845-1	1980	In cultured skin fibroblasts from normal and homozygous familial hypercholesterolemic subjects, a water-soluble polyoxyethylated derivative of cholesterol suppresses the incorporation of [2-14C]acetate into cholesterol and decreases the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol synthesis.	Water	98-103	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	249-296
26109375-5	2015	Explicit dependence of water polarizability on a distance between a water oxygen and Mg(2+) is derived from in vacuum MP2 calculations of Mg(2+)-water dimer.	Water	23-28	tryptase pseudogene 1	Homo sapiens	118-121
26109375-5	2015	Explicit dependence of water polarizability on a distance between a water oxygen and Mg(2+) is derived from in vacuum MP2 calculations of Mg(2+)-water dimer.	Water	68-73	tryptase pseudogene 1	Homo sapiens	118-121
26109375-5	2015	Explicit dependence of water polarizability on a distance between a water oxygen and Mg(2+) is derived from in vacuum MP2 calculations of Mg(2+)-water dimer.	Water	68-73	tryptase pseudogene 1	Homo sapiens	118-121
26661976-10	2016	DFT and MP2 calculations help identify plausible pathways for decomposition of H2 O and formation of H2.	Water	79-83	tryptase pseudogene 1	Homo sapiens	8-11
508733-12	1979	Like the acceleration of the deactivation reactions of the water-splitting enzyme system Y effect, the capacity for inducing the cytochrome b-559 photooxidation appeared dependent on the acidity of the NH group and on the number of halogenous substituents in the aromatic ring of the molecule.	Water	59-64	cytochrome b	Chlamydomonas reinhardtii	129-141
25813359-2	2015	This theory was used to determine the adsorption characteristics of beta-casein and beta-lactoglobulin at water/oil interfaces.	Water	106-111	casein beta	Homo sapiens	68-79
26338870-4	2015	Using the antibodies that specifically recognize previously characterized AQPs, two water-specific subtypes-AQP-Bom1 and AQP-Bom3-belonging to the Drosophila integral protein (DRIP) and Pyrocoelia rufa integral protein (PRIP) subfamilies of the insect AQP clade, respectively, were identified in the developing ovaries of B. mori.	Water	84-89	drip	Drosophila melanogaster	147-174
26338870-4	2015	Using the antibodies that specifically recognize previously characterized AQPs, two water-specific subtypes-AQP-Bom1 and AQP-Bom3-belonging to the Drosophila integral protein (DRIP) and Pyrocoelia rufa integral protein (PRIP) subfamilies of the insect AQP clade, respectively, were identified in the developing ovaries of B. mori.	Water	84-89	drip	Drosophila melanogaster	176-180
26372737-4	2016	Especially, compounds AR-1 and AR-4, decorated with strong electron-withdrawing NO2 substituent, showed augmented anion sensing properties, being capable of naked-eye detecting of F(-) and AcO(-) when the water content is lower than 15%.	Water	205-210	transcription factor 20	Homo sapiens	22-26
508733-13	1979	The greatest action towards cytochrome b-559 photooxidation was obtained with the most active acceleration of the deactivation reactions of the water-splitting enzyme system Y agents: carbonylcyanide-p-trifluoromethoxyphenylhydrazone, ANT 2p and ANT 2s.	Water	144-149	cytochrome b	Chlamydomonas reinhardtii	28-40
26338873-0	2015	Molecular machinery for vasotocin-dependent transepithelial water movement in amphibians: aquaporins and evolution.	Water	60-65	arginine vasopressin	Xenopus tropicalis	24-33
26338873-7	2015	AQP6vs, AQP2 and/or AQP6ub are also expressed in these epithelial cells and are translocated to the apical membrane in response to arginine vasotocin, thereby regulating water absorption/reabsorption.	Water	170-175	arginine vasopressin	Xenopus tropicalis	140-149
521493-8	1979	In contrast, the AH of C3d-coated red blood cells resulting from complement fixation in vivo (ie, cold agglutinin disease) or in vitro (eg, sucrose water reaction) was resistant to trypsin treatment.	Water	148-153	endogenous retrovirus group K member 13	Homo sapiens	23-26
26338873-10	2015	This finding suggested that AQP5 may be involved in water reabsorption from this organ under dehydration.	Water	52-57	aquaporin 5	Xenopus tropicalis	28-32
26784173-1	2016	Aquaporin-2, a member of the aquaporin family, is an arginine vasopressin-regulated water channel expressed in the renal collecting duct, and a promising marker of the concentrating and diluting ability of the kidney.	Water	84-89	aquaporin 2	Homo sapiens	0-11
525938-1	1979	Highly purified equine prolactin was prepared from equine pituitary glands (hypophysis) by serial extractions with water at pH 5.5, 0.1 M (NH4)2SO4 at pH 4.0, and 0.25 M (NH4)2SO4 at pH 5.5 to remove other hormones, and then finally with 70% ethanol at pH 9.3 to 10.0 to extract prolactin.	Water	115-120	prolactin	Equus caballus	23-32
26595324-6	2016	Thus, the transition temperature of ELPs in pure water is determined by two factors: the hydrogen bonding tendency of the pentamers and the number of pentamers per ELP.	Water	49-54	nuclear receptor subfamily 5 group A member 1	Homo sapiens	36-39
25819886-2	2015	This novel method can deposit MSN nanoparticles throughout the entire respiratory tract, including nasal, tracheobronchial and pulmonary regions using a water-based aerosol.	Water	153-158	moesin	Mus musculus	30-33
485096-2	1979	However, age-dependent differences in normal children"s DBH "activation" by water dilution +/- copper addition was revealed.	Water	76-81	dopamine beta-hydroxylase	Homo sapiens	56-59
26434147-14	2015	The presence of AQP3 leads to a five-fold increase in water permeability, which subsequently increases stratum corneum hydration.	Water	54-59	aquaporin 3 (Gill blood group)	Homo sapiens	16-20
26638997-8	2016	Both erythropoietin and curcumin treatments (individually or combined) equally reduced the hippocampal beta-amyloid accumulation and improved cognitive impairment in Morris water maze and passive avoidance tasks.	Water	173-178	erythropoietin	Rattus norvegicus	5-19
26008794-8	2015	One isoform of CAT was found in the roots when water supply was normal and three isoforms were observed under drought conditions.	Water	47-52	catalase-1	Triticum aestivum	15-18
233578-1	1979	The interaction of CrADP, an exchange-inert paramagnetic analogue of Mg-ADP, with yeast hexokinase has been studied by measuring the effects of CrADP on the longitudinal nuclear relaxation rate (1/T1) of the protons of water and the protons and phosphorus atom of enzyme-bound glucose-6-P.	Water	219-224	hexokinase	Saccharomyces cerevisiae S288C	88-98
26463974-6	2016	We found brain water content in the ipsilateral hemisphere and the tumor mass were significantly lower in PAR-1 KO than WT mice at day 12 after implantation of F98 cells (p &lt; 0.05).	Water	15-20	coagulation factor II (thrombin) receptor	Mus musculus	106-111
26493237-4	2016	Moreover, luminophores C1, C2, and C3 exhibit "on-off-on" luminescence switching properties in mixtures of water/tetrahydrofuran with increasing water content, which is different from the "on-off" switching for typical aggregation-caused quenching (ACQ) materials and "off-on" switching for traditional aggregation-induced emission (AIE) materials.	Water	107-112	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	23-37
26493237-4	2016	Moreover, luminophores C1, C2, and C3 exhibit "on-off-on" luminescence switching properties in mixtures of water/tetrahydrofuran with increasing water content, which is different from the "on-off" switching for typical aggregation-caused quenching (ACQ) materials and "off-on" switching for traditional aggregation-induced emission (AIE) materials.	Water	145-150	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	23-37
26983245-1	2015	OBJECTIVE: To observe the regulatory effect of Esculentoside A (EsA) on urination and the expression of AQP2 and AQP4 protein of kidney in water-loaded rats, and to discuss its mechanism of diuresis.	Water	139-144	aquaporin 4	Rattus norvegicus	113-117
465363-7	1979	It is suggested that depression of erythropoiesis during water deprivation in the rat depends on a reduced sensitivity to erythropoietin, possibly associated with decreased production of the hormone.	Water	57-62	erythropoietin	Rattus norvegicus	122-136
26118553-2	2015	While the adsorption of HF is described well using B3LYP, MP2 is required for a good description of the adsorption of H2O.	Water	118-121	tryptase pseudogene 1	Homo sapiens	58-61
253374-4	1978	h-1 always caused an increase in urine osmolality and a decrease in flow rate and free water clearance without change in blood pressure.	Water	87-92	H1.5 linker histone, cluster member	Homo sapiens	0-3
26925223-7	2015	Analysis of c-Fos labeling (functional changes) revealed developmentally-dependent increases in c-Fos positive cells in the dentate gyrus, CA3 and CA1 regions whereas training-dependent increases were noted in the CA3 and CA1 regions for the water-maze trained groups.	Water	242-247	carbonic anhydrase 1	Rattus norvegicus	222-225
27250797-0	2016	Polycyclic Aromatic Hydrocarbons in Surface Water of the Southeastern Japan Sea.	Water	44-49	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
27584958-0	2016	New Findings on the Mechanism of Perspiration Including Aquaporin-5 Water Channel.	Water	68-73	aquaporin 5	Homo sapiens	56-67
27584958-1	2016	Aquaporin-5 (AQP5) is a member of the water channel protein family.	Water	38-43	aquaporin 5	Homo sapiens	0-11
83123-8	1978	In water samples taken immediately above sandy sediments at beaches of the Kiel Fjord and the Kiel Bight (Baltic Sea, FRG), between 2.3 and 56.2% (average, 31.3%) of the total number of bacteria were actually metabolizing cells.	Water	3-8	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	113-116
27584958-1	2016	Aquaporin-5 (AQP5) is a member of the water channel protein family.	Water	38-43	aquaporin 5	Homo sapiens	13-17
27584958-8	2016	AQP5 may be involved in sweating and its translocation may help to increase the water permeability of the apical membranes of sweat glands.	Water	80-85	aquaporin 5	Homo sapiens	0-4
26098142-2	2015	Measurements of gas phase absorption spectra were demonstrated using H2O(g) as a function of relative humidity (RH).	Water	69-72	gastrin	Homo sapiens	16-19
670189-1	1978	The change in the distribution of the phosphate species containing 0 to 4 18O oxygens per Pi was investigated during medium Pi equilibrium HOH exchange catalyzed by myosin subfragment 1.	Water	139-142	myosin heavy chain 14	Homo sapiens	165-171
26203135-10	2015	The selective PI3Kgamma inhibitors AS252424 and AS605240 reduced brain water content surrounding corticotomy and improved neurological function after SBI.	Water	71-76	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	14-23
26203135-13	2015	PI3Kgamma siRNA reduced PI3Kgamma levels, decreased brain water content within peri-resection brain tissues, and improved neurological function after SBI.	Water	58-63	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	0-9
26524422-9	2016	The RAGE-binding capacity was higher in samples with a lower water activity (0.23).	Water	61-66	advanced glycosylation end-product specific receptor	Bos taurus	4-8
26186212-0	2015	Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice.	Water	12-17	APC, WNT signaling pathway regulator	Mus musculus	116-119
670189-8	1978	When correction is made for this contaminant, characteristics of the myosin intermediate Pi equilibrium HOH exchange are similar to those of myosin subfragment 1 medium exchange, and intermediate exchange data are in much closer agreement with other kinetic measurements.	Water	104-107	myosin heavy chain 14	Homo sapiens	69-75
26186212-6	2015	In CPC;Apc mice given chlorinated drinking water, tumors tended to develop in the colon, whereas in those that drank tap water, tumors were mostly observed in the small intestine.	Water	43-48	APC, WNT signaling pathway regulator	Mus musculus	7-10
26186212-8	2015	Chlorinated water altered the enteric environment by reducing the fecal populations of the obligatory anaerobes Clostridium perfringens and C. difficile, as well as species belonging to the Atopobium cluster, including Enterobacteriaceae and Staphylococcus sp., which was associated with colon tumorigenesis in CPC;Apc mice.	Water	12-17	APC, WNT signaling pathway regulator	Mus musculus	315-318
26836189-7	2016	Furthermore, although a Morris water maze test probe induced a steep (~4-fold) increment in the percentage of Arc+ cells in the CA3 region of the 10-month-old wild-type group, no such increment was observed in age-matched 3xTg-AD, whereas the amount of Arc+ cells in CA1 increased in both groups.	Water	31-36	carbonic anhydrase 1	Mus musculus	267-270
26186212-9	2015	These results suggest that differences in tumorigenesis among CPC;Apc mice consuming chlorinated versus tap water may be due to differences in gastrointestinal commensal populations.	Water	108-113	APC, WNT signaling pathway regulator	Mus musculus	66-69
678972-3	1978	Nevertheless, the total specific activities of CNP present in microsomal membranes and in a water-soluble form were not negligible, and suggest that this enzyme has a wide distribution among subcellular particles.	Water	92-97	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	47-50
26890738-4	2016	One behavioral aspect of cognitive reserve in mice is the capacity to cope with Abeta-associated stereotypies by switching to increasingly effective navigational search strategies in the Morris water maze.	Water	194-199	amyloid beta (A4) precursor protein	Mus musculus	80-85
356498-4	1978	Biliary water and electrolytes are augmented by gastrin, CCK-PZ, secretin and VIP and inhibited by Substance P.	Water	8-13	gastrin	Homo sapiens	48-55
27832660-1	2016	BACKGROUND/AIMS: ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide.	Water	110-115	endothelin 1	Mus musculus	17-21
26522287-3	2016	The potential of mean force (PMF) was calculated for transmembrane transportation of Na(+), Cl(-) and water molecule along the pore channel of penta-SLN complex.	Water	102-107	sarcolipin	Homo sapiens	149-152
26522287-4	2016	The root mean square deviation (RMSD) of the SLN pentamer in POPC membrane showed that the stabilized SLN protein complex could exist in the membrane and that the Na(+) and Cl(-) could not permeate through the channel when the pore was under the vacuum state, but the water could permeate through from cytoplasm to lumen.	Water	268-273	sarcolipin	Homo sapiens	45-48
26522287-4	2016	The root mean square deviation (RMSD) of the SLN pentamer in POPC membrane showed that the stabilized SLN protein complex could exist in the membrane and that the Na(+) and Cl(-) could not permeate through the channel when the pore was under the vacuum state, but the water could permeate through from cytoplasm to lumen.	Water	268-273	sarcolipin	Homo sapiens	102-105
25906910-0	2015	Novel oral formulation approach for poorly water-soluble drug using lipocalin-type prostaglandin D synthase.	Water	43-48	prostaglandin D2 synthase	Rattus norvegicus	68-107
26026483-11	2015	In the samples of treated water with conventional treatment, using pre-oxidation by permanganate and distribution network, CHCl2I, CHBrClI, CHClI2, CHBrI2 and CHI3 were detected at very low concentrations (1-18ngL(-1)).	Water	26-31	chitinase 1	Homo sapiens	159-163
15728-6	1977	Upon discharge and contact with sea water, the tubules solubilize and adhere to various substrates and prey.	Water	36-41	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	32-35
26167467-5	2015	To estimate the changes in water transport via AQP2 and sodium transport via NKCC2 and ENaC, u-NKCC2, the gamma fraction of ENaC (u-ENaCgamma), and u-AQP2 were measured at baseline and after infusion with 3% hypertonic saline.	Water	27-32	aquaporin 2	Homo sapiens	47-51
401986-2	1977	The prescription of the cyclin (600 mg daily) is always determined by a fall of the urinary osmolarity (-36%) and by a dramatic improvement of the free water clearance (+ 60%); consecutively, we observe an increase of natremia in 8 out of 9 cases.	Water	152-157	proliferating cell nuclear antigen	Homo sapiens	24-30
27818851-8	2015	Smaller average cloud fraction and liquid water are found within footprints with more sea ice.	Water	42-47	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	86-89
401986-3	1977	Associated with Spironolactone (200 mg daily) the anti-ADH activity persists (the free water clearance becomes positive in 5 out of 10 patients), in spite of the natriuretic activity of anti-aldosterone ; a minimal fall of the natremia is observed in only 2 cases.	Water	87-92	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	55-58
605360-2	1977	Gastrin converted the normal mucosal absorption of water and sodium into a net secretion.	Water	51-56	gastrin	Homo sapiens	0-7
26463236-1	2015	A mononuclear Co complex, [Co(III)(DPK OH)2]Cl (DPK = di(2-pyridyl)ketone), was synthesized and reported as a stable catalyst in visible light-driven water oxidation.	Water	150-155	TAO kinase 3	Homo sapiens	35-38
26463236-1	2015	A mononuclear Co complex, [Co(III)(DPK OH)2]Cl (DPK = di(2-pyridyl)ketone), was synthesized and reported as a stable catalyst in visible light-driven water oxidation.	Water	150-155	TAO kinase 3	Homo sapiens	48-51
17748555-5	1976	This influx of subtropical water into the region is reflected in positive anomalies of temperature, salinity, and sea level.	Water	27-32	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	114-117
26489820-0	2015	Molecular dynamics insights into human aquaporin 2 water channel.	Water	51-56	aquaporin 2	Homo sapiens	39-50
26489820-1	2015	In this study, the first molecular dynamics simulation of the human aquaporin 2 is performed and for a better understanding of the aquaporin 2 permeability performance, the characteristics of water transport in this protein channel and key biophysical parameters of AQP2 tetramer including osmotic and diffusive permeability constants and the pore radius are investigated.	Water	192-197	aquaporin 2	Homo sapiens	68-79
977950-3	1976	Water soluble glucans synthesized from the reaction of glycosyltransferases of S. mutans strain AHT, FA-I, and Ingbritt with sucrose, that have a high content of alpha-1,6 and a low content of alpha-1, 3 glucosidic linkages, were less effective to activate the complement system.	Water	0-5	adrenoceptor alpha 1D	Homo sapiens	162-169
26489820-3	2015	The resulting water permeability characteristics of this protein channel showed that the water permeability of the human AQP2 is in a mean range in comparison with other human aquaporins family.	Water	14-19	aquaporin 2	Homo sapiens	121-125
26489820-3	2015	The resulting water permeability characteristics of this protein channel showed that the water permeability of the human AQP2 is in a mean range in comparison with other human aquaporins family.	Water	89-94	aquaporin 2	Homo sapiens	121-125
26489820-4	2015	Finally, the results reported in this research demonstrate that molecular dynamics simulation of human AQP2 provided useful insights into the mechanisms of water permeation and urine concentration in the human kidney.	Water	156-161	aquaporin 2	Homo sapiens	103-107
977950-3	1976	Water soluble glucans synthesized from the reaction of glycosyltransferases of S. mutans strain AHT, FA-I, and Ingbritt with sucrose, that have a high content of alpha-1,6 and a low content of alpha-1, 3 glucosidic linkages, were less effective to activate the complement system.	Water	0-5	adrenoceptor alpha 1D	Homo sapiens	193-200
25940835-2	2015	The present work introduces a new in vivo approach to measure the water resistance of sunscreens on the actual skin of subjects, which can be easily applied to salt, chlorine and tap waters.	Water	66-71	filamin B	Homo sapiens	179-182
947823-0	1976	[Sanitary protection of the water areas of the ports and coastal zones of the Black Sea basin].	Water	28-33	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	84-87
25855780-2	2015	Because cAMP is a central modulator of arginine vasopressin (AVP)-induced water transport in the renal collecting duct (CD), we hypothesized that if expressed in the CD, P2Y12-R may play a role in renal handling of water in health and in nephrogenic diabetes insipidus.	Water	74-79	purinergic receptor P2Y12	Rattus norvegicus	170-175
819249-6	1976	Water loading decreased plasma AVP and osmolality to 0.6 +/- 0.2 muU/ml and 282 +/- 6 mosmol/kg, respectively.	Water	0-5	arginine vasopressin	Macaca mulatta	31-34
25855780-2	2015	Because cAMP is a central modulator of arginine vasopressin (AVP)-induced water transport in the renal collecting duct (CD), we hypothesized that if expressed in the CD, P2Y12-R may play a role in renal handling of water in health and in nephrogenic diabetes insipidus.	Water	215-220	purinergic receptor P2Y12	Rattus norvegicus	170-175
1260002-4	1976	Since the fraction of A term estimated was approximately 80% for myoglobin fluoride and approximately 35% for myoglobin water, the effective symmetry for myoglobin fluoride is determined to be as close as D4h, while that for myoglobin water seems to have lower symmetry components.	Water	120-125	myoglobin	Homo sapiens	110-119
26214274-1	2015	Free standing films of a genetically engineered silk-elastin-like protein (SELP) were prepared using water and formic acid as solvents.	Water	101-106	selectin P	Homo sapiens	48-73
26214274-1	2015	Free standing films of a genetically engineered silk-elastin-like protein (SELP) were prepared using water and formic acid as solvents.	Water	101-106	selectin P	Homo sapiens	75-79
1260002-4	1976	Since the fraction of A term estimated was approximately 80% for myoglobin fluoride and approximately 35% for myoglobin water, the effective symmetry for myoglobin fluoride is determined to be as close as D4h, while that for myoglobin water seems to have lower symmetry components.	Water	120-125	myoglobin	Homo sapiens	110-119
1260002-4	1976	Since the fraction of A term estimated was approximately 80% for myoglobin fluoride and approximately 35% for myoglobin water, the effective symmetry for myoglobin fluoride is determined to be as close as D4h, while that for myoglobin water seems to have lower symmetry components.	Water	120-125	myoglobin	Homo sapiens	110-119
816680-2	1976	ABS, the supernatant of smooth B. abortus phenol-protected suspensions, is a protein, lipid, sugar and ARN complex containing all amino acids found in phenol-water fractions from B. abortus and B. melitensis.	Water	158-163	DEAD box helicase 41	Mus musculus	0-3
26208470-9	2015	Finally, the water shunt elements AQP4, AQP5, and M3R were also demonstrated in OSCs of the human cochlea.	Water	13-18	aquaporin 5	Homo sapiens	40-44
1208098-2	1975	In the presence of water vapor, aldehydes and HCN are formed separately in regions of different temperatures along the reacting gas.	Water	19-24	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	46-49
1191254-3	1975	A simple method is given for isolating from ram spermatozoa a water-soluble form of acrosin (a trypsin-like enzyme) which is about 25% pure.	Water	62-67	acrosin	Homo sapiens	84-91
26616272-7	2015	Mice exposed to NMDAR-CSF showed impaired spatial memory, as detected with the Morris water maze test.	Water	86-91	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	16-21
1191254-18	1975	Like trypsin, acrosin is activated, up to 60%, by 2-methyl-propan-2-ol, dimethyl sulphoxide, and some other water-miscible solvents.	Water	108-113	acrosin	Homo sapiens	14-21
1177491-6	1975	The poly(1-Me-5-VIm)-catalyzed hydrolysis of S18- in ethanol-water was analyzed in terms of a simple Michaelis-Menten type mechanism.	Water	61-66	vimentin	Homo sapiens	16-19
26610608-3	2015	Labellar Desi expression was significantly elevated under arid conditions, accompanied by an increase in water ingestion by adults.	Water	105-110	Desiccate	Drosophila melanogaster	9-13
26610608-4	2015	Desi overexpression also promoted water ingestion.	Water	34-39	Desiccate	Drosophila melanogaster	0-4
26610608-5	2015	In contrast, a knockdown of Desi expression reduced feeding as well as water ingestion due to a drastic decrease in the gustatory sensillar sensitivity for all tested tastants.	Water	71-76	Desiccate	Drosophila melanogaster	28-32
26610608-6	2015	These results indicate that Desi helps protect insects from desiccation damage by not only preventing dehydration through the integument but also accelerating water ingestion via elevated taste sensitivities of the sensilla.	Water	159-164	Desiccate	Drosophila melanogaster	28-32
26611539-0	2015	Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation.	Water	25-30	heme oxygenase 1	Homo sapiens	82-86
1177492-1	1975	The water solubility of poly(1-Me-5-VIm) has made it possible to achieve phenomenal rate enhancements and to gain even greater insight into the mechanism of catalysis by polymeric imidazoles.	Water	4-9	vimentin	Homo sapiens	36-39
1177492-9	1975	The intermediacy of an apolar polymer substrate complex for the poly(1-Me-5-VIm)-catalyzed hydrolysis of S12- in water was given support by studies of the effect of temperature on the rate of hydrolysis.	Water	113-118	vimentin	Homo sapiens	76-79
1122917-1	1975	A column packed with calcium-free bovine aorta elastin provided good separations of mixtures of bile salts when water was the moving phase.	Water	112-117	elastin	Bos taurus	47-54
26578166-2	2015	In this study, the neuroprotective effects of water extract of TGY were tested on rotenone-intoxicated and human alpha-synuclein transgenic Drosophila PD models.	Water	46-51	synuclein alpha	Homo sapiens	113-128
26346804-0	2015	Water quality assessment using water quality index and geographical information system methods in the coastal waters of Andaman Sea, India.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	128-131
1125392-3	1975	Different pathways of self-organization of myoglobin are considered; the most favourable structures corresponding to the greatest number of dehydrated bulky hydrophobic groups and to all the strongly hydrophilic groups exposed to water are selected at every stage of the given pathway and the others are neglected.	Water	230-235	myoglobin	Homo sapiens	43-52
235372-8	1975	Chemical shift measurements (by NMR) on the C-2 and C-5 protons of imidazole in micellar N alpha-dodecanoyl-L-histidine indicate that the imidazole group is, indeed, positioned at the water-micelle interface.	Water	184-189	complement C2	Homo sapiens	44-47
26553610-3	2015	We report on methane excess in sea ice-influenced water masses in the interior Arctic Ocean and provide evidence that sea ice is a potential source.	Water	50-55	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	31-34
235372-8	1975	Chemical shift measurements (by NMR) on the C-2 and C-5 protons of imidazole in micellar N alpha-dodecanoyl-L-histidine indicate that the imidazole group is, indeed, positioned at the water-micelle interface.	Water	184-189	complement C5	Homo sapiens	52-55
26526066-2	2015	Recent studies showed that the water channel aquaporin-4 (AQP4) mediates soluble Abeta clearance from the brain parenchyma along the paravascular pathway.	Water	31-36	amyloid beta (A4) precursor protein	Mus musculus	81-86
24442778-0	1974	[Effect of water stress on phosphoenolpyruvate carboxylase activity in Mesembryanthemum crystallinum (L.)].	Water	11-16	phosphoenolpyruvate carboxykinase 1	Homo sapiens	27-58
26641339-6	2015	The leachate DRP concentration was linearly related to soil water-extractable P and CaCl-extractable P with values of 0.90 and 0.93, respectively, and to Bray-1 P and FeO-impregnated filter paper extractable P in a split-line model with a change point.	Water	60-65	density regulated re-initiation and release factor	Homo sapiens	13-16
4692744-0	1973	[Effect of sodium iodide on water content of the Lig.	Water	28-33	ubiquitin conjugating enzyme E2 K	Bos taurus	49-52
26459070-2	2015	AQP4 is a key regulator of water metabolism, and changes in its expression following brain injury are associated with pathological changes in the damaged side of the brain; however, the effects of brain injury on AQP4 and injury-induced pathological changes in the contralateral non-damaged side of the brain remain to be fully elucidated.	Water	27-32	aquaporin 4	Rattus norvegicus	0-4
26399304-6	2015	Further QM calculations of the Pd(PPh3)2-H2O system confirmed the direction (PdH) and stability of this bonding.	Water	41-44	protein phosphatase 4 catalytic subunit	Homo sapiens	31-38
4784147-0	1973	Effect of clofibrate on water metabolism in hypothalamic and ADH-resistant diabetes insipidus.	Water	24-29	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	61-64
26388205-3	2015	This method was used to obtain the solution structure of the Co(I) intermediate of cobaloxime, which is a non-noble metal catalyst for solar hydrogen production from water.	Water	166-171	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	61-66
25948733-7	2015	Interestingly, the reduction in Ca(2+) influx in CBSb-deficient fish was observed only in fish that were acclimated to low-Ca(2+) water (i.e., 25 muM Ca(2+); control: 250 muM Ca(2+)).	Water	130-135	cystathionine beta-synthase b	Danio rerio	49-53
4664584-2	1972	In a dimethyl sulphoxide-water medium it reacts rapidly (3h) with bovine insulin, and substitution occurs quantitatively at the N-terminal amino groups and at the in-amino groups of lysine residues.	Water	25-30	insulin	Bos taurus	73-80
26542007-0	2015	X-ray reflectivity and grazing incidence diffraction studies of interaction between human adhesion/growth-regulatory galectin-1 and DPPE-GM1 lipid monolayer at an air/water interface.	Water	167-172	galectin 1	Homo sapiens	117-127
26125516-5	2015	When the water coating is removed, the X-ray photoelectron spectroscopy pattern of V2p showed that the V-MOF changes to MIL-100V(IV) and MIL-101V(IV) at 298 K because of the action of O2.	Water	9-14	T cell receptor gamma variable 9	Homo sapiens	83-86
5435780-2	1970	The product of L(p) and the bulk viscosity of water, eta, was independent of temperature for both dog and man which indicates that the geometry of the red cell membrane is not temperature-sensitive over our experimental temperature range in either species.	Water	46-51	endothelin receptor type A	Canis lupus familiaris	53-56
26272610-7	2015	Instead, the location of the Tyr-39 side chain of Ran between the gamma-phosphate and Gln-69 prevents the optimal positioning of the attacking water molecule by the Gln-69 relative to the gamma-phosphate.	Water	143-148	RAN, member RAS oncogene family	Homo sapiens	50-53
25885117-2	2015	CHCl3 and CHBr3 were the dominant compounds in air and water of the Cl-SP and Br-SP, respectively.	Water	55-60	calmodulin like 5	Homo sapiens	68-83
5352172-0	1969	[The effect of Dzhermuksk mineral water on the content of acetylcholine and cholinesterase activity in the affected sciatic nerve under experimental conditions].	Water	34-39	butyrylcholinesterase	Homo sapiens	76-90
26330830-1	2015	Aquaporin-4 regulates water molecule channels and is important in tissue regulation and water transportation in the brain.	Water	22-27	aquaporin 4	Rattus norvegicus	0-11
5395849-0	1969	[Effect of water restriction on the storage of fat and its fatty acid composition.	Water	11-16	CD36 molecule	Mus musculus	47-50
26122204-0	2015	Water extract of brewers" rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/beta-catenin downstream signaling pathway in brewers" rice-treated rats with azoxymethane-induced colon carcinogenesis.	Water	0-5	catenin beta 1	Homo sapiens	150-162
26191374-0	2015	Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.	Water	36-41	DNA topoisomerase II alpha	Homo sapiens	91-101
5718631-0	1968	Effect of gastrin on jejunal water absorption.	Water	29-34	gastrin	Homo sapiens	10-17
4294420-1	1967	Yeast cells, Candida utilis, in water suspension and in the absence of electrolytes were found to be very sensitive to several proteins of moderate size, including ribonuclease, protamine, lysozyme, bovine serum albumin, cytochrome c, and myoglobin.	Water	32-37	ribonuclease	Saccharomyces cerevisiae S288C	164-176
25914328-1	2015	A new pentadentate oxime has been designed to drive the preferential coordination favored by Co(I) in catalysts used for proton/water reduction.	Water	128-133	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	93-98
26047140-5	2015	Unlike wild-type controls, Iqgap2-/- mice treated with 3% dextran sulfate sodium (DSS) in water for 13 days displayed no injury to colonic epithelium.	Water	90-95	IQ motif containing GTPase activating protein 2	Mus musculus	27-33
6066516-0	1967	Differentiation of LAS and ABS in water.	Water	34-39	lipoic acid synthetase	Homo sapiens	19-22
26022326-5	2015	Collectively the data illustrate that Baltic Sea microbes are unique and highly diverse, and well adapted to this brackish-water ecosystem, findings that represent a novel base-line knowledge necessary for monitoring purposes and a sustainable management.	Water	123-128	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	45-48
5627116-0	1967	[Free water observations on the behavior of sand eel schools (Ammodytidae) in the western Baltic Sea].	Water	6-11	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	97-100
25723716-6	2015	The PAH-RHD[GN] gene diversity as well as nahAc and nidA gene copy numbers decreased in the following order: deposited sediment&gt;SPS&gt;overlying water.	Water	148-153	Rh blood group D antigen	Homo sapiens	8-11
6032180-0	1967	Proteolytic degradation of myosin and the meromyosins by a water-insoluble polyanionic derivative of trypsin: properties of a helical subunit isolated from heavy meromyosin.	Water	59-64	myosin heavy chain 14	Homo sapiens	27-33
25736595-4	2015	The INCA-N model has been applied to the Ganges, Brahmaputra and Meghna river systems to simulate flow and water quality along the rivers under a range of future climate conditions.	Water	107-112	caspase recruitment domain family member 17	Homo sapiens	4-8
5909820-0	1966	Body temperature changes in sea-water immersion.	Water	32-37	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	28-31
13931361-0	1962	[Protective effect on anaphylactic shock in guinea pigs of mineral water from the "Mieszko" spring in Szczawno spa].	Water	67-72	pulmonary surfactant-associated protein A	Cavia porcellus	111-114
25640640-0	2015	Decrease in water clarity of the southern and central North Sea during the 20th century.	Water	12-17	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	60-63
13688816-0	1960	[Gangroenous abscess of the lung caused by aspiration of sea water].	Water	61-66	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	57-60
25280013-1	2015	A simple and effective method was reported for the preparation from MEH-PPV of conjugated polymer nanoparticles (Pdots) that are water-soluble and well dispersed.	Water	129-134	epoxide hydrolase 1	Homo sapiens	68-71
25913814-1	2015	A highly efficient and robust heterogeneous photocatalytic hydrogen evolution system was established for the first time by using the CoP/CdS hybrid catalyst in water under solar irradiation.	Water	160-165	caspase recruitment domain family member 16	Homo sapiens	133-136
18141171-0	1949	The effect of sea water on the biochemical oxidation of sewage.	Water	18-23	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	14-17
25913814-1	2015	A highly efficient and robust heterogeneous photocatalytic hydrogen evolution system was established for the first time by using the CoP/CdS hybrid catalyst in water under solar irradiation.	Water	160-165	CDP-diacylglycerol synthase 1	Homo sapiens	137-140
18120003-0	1949	[The action of folliculin and progesterone on water metabolism in pregnancy].	Water	46-51	folliculin	Homo sapiens	15-25
25918405-0	2015	Hydration water mobility is enhanced around tau amyloid fibers.	Water	10-15	microtubule associated protein tau	Homo sapiens	44-47
25918405-5	2015	In comparison with monomeric tau, hydration water on the surface of tau fibers is more mobile, as evidenced by an increased fraction of translationally diffusing water molecules, a higher diffusion coefficient, and increased mean-squared displacements in neutron scattering experiments.	Water	44-49	microtubule associated protein tau	Homo sapiens	68-71
33744731-1	2021	Large volumes of water become contaminated with hydrocarbons, surfactants, salts and other chemical agents during Oil & Gas exploration activities, resulting in a complex wastewater stream known as produced water (PW).	Water	17-22	gastrin	Homo sapiens	120-123
25918405-5	2015	In comparison with monomeric tau, hydration water on the surface of tau fibers is more mobile, as evidenced by an increased fraction of translationally diffusing water molecules, a higher diffusion coefficient, and increased mean-squared displacements in neutron scattering experiments.	Water	162-167	microtubule associated protein tau	Homo sapiens	68-71
25918405-6	2015	Fibers formed by the hexapeptide (306)VQIVYK(311) were taken as a model for the tau fiber core and studied by molecular dynamics simulations, revealing that hydration water dynamics around the core domain is significantly reduced after fiber formation.	Water	167-172	microtubule associated protein tau	Homo sapiens	80-83
25918405-7	2015	Thus, an increase in water dynamics around the fuzzy coat is proposed to be at the origin of the experimentally observed increase in hydration water dynamics around the entire tau fiber.	Water	21-26	microtubule associated protein tau	Homo sapiens	176-179
25918405-7	2015	Thus, an increase in water dynamics around the fuzzy coat is proposed to be at the origin of the experimentally observed increase in hydration water dynamics around the entire tau fiber.	Water	143-148	microtubule associated protein tau	Homo sapiens	176-179
25918405-9	2015	Detection of the enhanced hydration water mobility around tau fibers is conjectured to potentially contribute to the early diagnosis of Alzheimer patients by diffusion MRI.	Water	36-41	microtubule associated protein tau	Homo sapiens	58-61
34030242-3	2021	Various policy frameworks aim to hinder its progress but eutrophication-relevant water quality variables, such as chlorophyll-a concentrations, still exhibit opposite temporal trends in various Baltic Sea marine and coastal waters.	Water	81-86	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	201-204
25955978-8	2015	Hence, interacting acidic and basic residues form favorable AspH(0)-H2O(0)-Arg(+) interactions with hydronium but unfavorable Asp(-)-X(-)/X(+)-Arg(+) interactions with anions/cations.	Water	68-71	aspartate beta-hydroxylase	Homo sapiens	60-64
25910195-9	2015	There was decreased performance in the Morris Water Maze task in 6 month old Aldh2 (-/-) mice.	Water	46-51	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	77-82
34030242-5	2021	We find that it is necessary to distinguish more and less isolated coastal waters, based on their water exchanges with the open sea, to capture different coastal eutrophication dynamics.	Water	75-80	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	128-131
34030242-7	2021	In the open sea, trends in eutrophication conditions correlate best with trends in climatic and hydrospheric drivers, like wind speed and water salinity, respectively.	Water	138-143	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	12-15
33984648-5	2021	At the optimized conditions, calibration graphs of analytes were linear in the concentration range of 0.03-300 ng mL-1 for water samples, and 0.1-200 ng mL-1 for plasma samples.	Water	123-128	L1 cell adhesion molecule	Mus musculus	114-118
25830254-1	2015	The water cavity of yeast thioredoxin 1 (yTrx1) is an ancestral, conserved structural element that is poorly understood.	Water	4-9	thioredoxin TRX1	Saccharomyces cerevisiae S288C	41-46
25830254-6	2015	The dynamics of the D24A mutant of yTrx1 at multiple time scales revealed that the D24A mutant presents motions at different time scales near the active site, interaction loops, and water cavity, revealing the existence of a smaller dissected cavity.	Water	182-187	thioredoxin TRX1	Saccharomyces cerevisiae S288C	35-40
25830254-7	2015	Molecular dynamics simulation, along with experimental molecular dynamics, allowed a detailed description of the water cavity in wild-type yTrx1 and D24A.	Water	113-118	thioredoxin TRX1	Saccharomyces cerevisiae S288C	139-144
33984648-7	2021	Also, the limits of detection (LODs) were from 0.01 to 0.02 ng mL-1 for water samples and 0.03 to 0.1 ng mL-1 for plasma samples.	Water	72-77	L1 cell adhesion molecule	Mus musculus	63-67
33862571-2	2021	The thixotropic solution of alpha-CD/C9-PVA ICS was prepared by mixing alpha-CD and C9-PVA in deionized water.	Water	104-109	adrenocortical dysplasia	Mus musculus	28-36
25894980-0	2015	Identification of Surface Water Quality along the Coast of Sanya, South China Sea.	Water	26-31	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	78-81
33744543-8	2021	Co3O4 can activate H2O molecules to provide sufficient OH- species to promote MOR.	Water	19-22	opioid receptor mu 1	Homo sapiens	78-81
25931819-7	2015	Additionally, this paper evidenced the dimer had the basic structural unit of Cu(2+)-FS in water, theoretically simulated the formation of Cu(2+)-FS nanoparticles, and identified that Cu(2+)-FS activity in decreasing glycoprotein IIb/IIIa, P-selectin, and IL-8 was responsible for the antithrombotic action.	Water	91-96	selectin P	Homo sapiens	240-250
33756385-4	2021	In this study, a series of LCAs were performed on different operational scenarios for a 1000 gallon per day, pilot-scale Eco-Machine  that, in addition to producing irrigation-quality water, also produces duckweed biomass for aquaculture.	Water	184-189	ciliogenesis associated kinase 1	Homo sapiens	121-124
25831129-4	2015	The accumulation of floating plastic in the Mediterranean Sea (between 1,000 and 3,000 tons) is likely related to the high human pressure together with the hydrodynamics of this semi-enclosed basin, with outflow mainly occurring through a deep water layer.	Water	244-249	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	58-61
33581529-4	2021	Pronounced accumulation of river water and riverine DOM was also observed in the anticyclonic Beaufort Gyre at the eastern stations of the northern Chukchi Sea in association with a long water residence time.	Water	33-38	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	156-159
25637473-1	2015	OBJECTIVE: The role of renal aquaporin-2 (AQP2) water channel turnover in patients with liver cirrhosis, portal hypertension and water retention remains unclear.	Water	48-53	aquaporin 2	Homo sapiens	29-40
25637473-1	2015	OBJECTIVE: The role of renal aquaporin-2 (AQP2) water channel turnover in patients with liver cirrhosis, portal hypertension and water retention remains unclear.	Water	48-53	aquaporin 2	Homo sapiens	42-46
25702082-10	2015	This study therefore illustrates the potential, and proposes a pathway, of UHPLC-(Q)-TOF combined with POCIS in situ pre-concentration for both quantitative and screening analyses of organic contaminants in water.	Water	207-212	FEZ family zinc finger 2	Homo sapiens	85-88
25847104-0	2015	Assessment for water quality by artificial neural network in Daya Bay, South China Sea.	Water	15-20	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	83-86
25847104-9	2015	The rest of the monitoring sites were in the south, central and eastern parts of Daya Bay, which are areas that experience water exchanges from South China Sea.	Water	123-128	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	156-159
25986490-11	2015	This work provides a map of the conserved water molecules helpful for deciphering SHMT mechanism and for rational design of molecular engineering experiments.	Water	42-47	serine hydroxymethyltransferase 1	Homo sapiens	82-86
34038090-0	2021	Multiomics Imaging Using High-Energy Water Gas Cluster Ion Beam Secondary Ion Mass Spectrometry [(H2O)n-GCIB-SIMS] of Frozen-Hydrated Cells and Tissue.	Water	37-42	gastrin	Homo sapiens	43-46
26404464-5	2015	We find that CTRP6 specifically suppresses the alternative pathway of the complement system by competing with factor B for C3(H2O) binding.	Water	126-129	C1q and tumor necrosis factor related protein 6	Mus musculus	13-18
25738586-9	2015	The reaction enthalpies of the formation of ssip and cip of [Mg(CO2)(H2O)16]( +) are -36 +- 4 kJ mol(-1) and -30 +- 9 kJ mol(-1), respectively, which were estimated based on the average temperature changes during the ion-molecule reaction between CO2 and [Mg(H2O)16]( +).	Water	69-72	complement C2	Homo sapiens	64-67
25738586-9	2015	The reaction enthalpies of the formation of ssip and cip of [Mg(CO2)(H2O)16]( +) are -36 +- 4 kJ mol(-1) and -30 +- 9 kJ mol(-1), respectively, which were estimated based on the average temperature changes during the ion-molecule reaction between CO2 and [Mg(H2O)16]( +).	Water	69-73	complement C2	Homo sapiens	64-67
34038090-0	2021	Multiomics Imaging Using High-Energy Water Gas Cluster Ion Beam Secondary Ion Mass Spectrometry [(H2O)n-GCIB-SIMS] of Frozen-Hydrated Cells and Tissue.	Water	98-101	gastrin	Homo sapiens	43-46
29124204-1	2015	Background: Aquaporin-8 (AQP8), a member of the aquaporin water channel family, is expressed in various tissue and cells, including liver, testis, and pancreas.	Water	58-63	aquaporin 8	Mus musculus	12-23
34038090-3	2021	We have explored the possibility of using water gas cluster ion beam secondary ion mass spectrometry [(H2O)n-GCIB-SIMS] as an analytical tool for multiomics assay.	Water	42-47	gastrin	Homo sapiens	48-51
29124204-1	2015	Background: Aquaporin-8 (AQP8), a member of the aquaporin water channel family, is expressed in various tissue and cells, including liver, testis, and pancreas.	Water	58-63	aquaporin 8	Mus musculus	25-29
25587115-4	2015	Vasopressin 2 receptor activation increases cAMP and activates PKA, which, in turn, phosphorylates aquaporin (AQP)2, triggering apical membrane accumulation, increased collecting duct permeability, and water reabsorption.	Water	202-207	aquaporin 2	Mus musculus	110-115
25587122-1	2015	Collecting duct-derived endothelin (ET)-1 is an autocrine inhibitor of Na(+) and water reabsorption; its deficiency causes hypertension and water retention.	Water	81-86	endothelin 1	Mus musculus	24-41
25587122-1	2015	Collecting duct-derived endothelin (ET)-1 is an autocrine inhibitor of Na(+) and water reabsorption; its deficiency causes hypertension and water retention.	Water	140-145	endothelin 1	Mus musculus	24-41
34038090-3	2021	We have explored the possibility of using water gas cluster ion beam secondary ion mass spectrometry [(H2O)n-GCIB-SIMS] as an analytical tool for multiomics assay.	Water	103-106	gastrin	Homo sapiens	48-51
25609088-4	2015	Expression of AQP1 with CAII in Xenopus oocytes or mammalian cells increased water flux relative to AQP1 expression alone.	Water	77-82	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	14-18
34037027-1	2021	Layered heterometallic phosphates {Mn(H2O)4}2Mn(H2O)2Ru2(PO4)4(H2O)2 (1) with a new topology were constructed from Ru2(PO4)46- and Mn2+ in the presence of anions as assisting reactants whose alkaline strength plays a key role in directing a different number of lattice water-intercalated structures.	Water	38-41	doublecortin domain containing 2	Homo sapiens	115-125
34037027-1	2021	Layered heterometallic phosphates {Mn(H2O)4}2Mn(H2O)2Ru2(PO4)4(H2O)2 (1) with a new topology were constructed from Ru2(PO4)46- and Mn2+ in the presence of anions as assisting reactants whose alkaline strength plays a key role in directing a different number of lattice water-intercalated structures.	Water	48-51	doublecortin domain containing 2	Homo sapiens	115-125
25886760-0	2015	Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice.	Water	9-14	heart and neural crest derivatives expressed 2	Mus musculus	85-88
26364882-4	2015	During the process, local water-like droplets deposition can be obviously observed in the confinement between the Si/SiO2 surfaces and the KOH-modified tungsten tip.	Water	26-31	TOR signaling pathway regulator	Homo sapiens	161-164
34037027-1	2021	Layered heterometallic phosphates {Mn(H2O)4}2Mn(H2O)2Ru2(PO4)4(H2O)2 (1) with a new topology were constructed from Ru2(PO4)46- and Mn2+ in the presence of anions as assisting reactants whose alkaline strength plays a key role in directing a different number of lattice water-intercalated structures.	Water	48-51	doublecortin domain containing 2	Homo sapiens	115-125
34029465-8	2021	These COF nanofilms functionalize the unactivated C-H bonds in water with a high catalytic yield (45-99%) and with a high degree of selectivity (cis:trans = 155:1; 3 :2  = 257:1, for cis-1,2-dimethylcyclohexane).	Water	63-68	suppressor of cytokine signaling 1	Homo sapiens	183-188
26374005-6	2015	It is found that MP2 values for the methane binding energies and the cohesive energies of the water clusters without methane are in close agreement with the QMC benchmarks, but the agreement is aided by partial cancelation between 2-body and beyond-2-body errors of MP2.	Water	94-99	tryptase pseudogene 1	Homo sapiens	17-20
26374005-6	2015	It is found that MP2 values for the methane binding energies and the cohesive energies of the water clusters without methane are in close agreement with the QMC benchmarks, but the agreement is aided by partial cancelation between 2-body and beyond-2-body errors of MP2.	Water	94-99	tryptase pseudogene 1	Homo sapiens	266-269
25498622-1	2015	beta-Carotene (beta-C) is a well-established natural antioxidant agent, but its poor water-solubility, low chemical stability and low bioavailability limit its application in food, pharmaceuticals and cosmetics industries.	Water	85-90	colony stimulating factor 2 receptor subunit beta	Homo sapiens	0-21
25498622-2	2015	Thus it is critical to develop an efficient method to improve the water solubility and stability of beta-C.	Water	66-71	colony stimulating factor 2 receptor subunit beta	Homo sapiens	100-106
33890594-5	2021	Compound Co2[(O2P(CH2CH2COO)(C6H5)(H2O)]2 2H2O (3) presents a 1D structure composed of zig-zag chains, formed by edge-sharing cobalt octahedra, with the phenyl groups pointing outside.	Water	35-38	complement C2	Homo sapiens	9-12
25637697-1	2015	Aquaporin 9 (AQP9), an aquaglyceroporin, is not only permeable to water but also to non-charged solutes, such as lactate.	Water	66-71	aquaporin 9	Mus musculus	0-11
25637697-1	2015	Aquaporin 9 (AQP9), an aquaglyceroporin, is not only permeable to water but also to non-charged solutes, such as lactate.	Water	66-71	aquaporin 9	Mus musculus	13-17
26348154-4	2015	Three major structural and thermodynamic characteristics of the IT-state relative to the N-state in beta2m protein are detected that contribute to the increased amyloidogenic potential: (i) the disruption of the edge D-strand, (ii) the increased solvent-exposed hydrophobic interface, and (iii) the increased solvation free energy (less affinity toward solvent water).	Water	361-366	beta-2-microglobulin	Homo sapiens	100-106
34018925-6	2021	NPF (Drosophila NPY) neurons are postsynaptic to Janu-AstA for water seeking and feeding through the AstA-R2 galanin-like receptor.	Water	63-68	neuropeptide F	Drosophila melanogaster	0-3
26205366-1	2015	Glutathione S-transferases (EC: 2.5.1.18, GSTs) are phase II detoxification enzymes that catalyze the conjugation of various electrophilic compounds to glutathione (GSH), thus usually producing less reactive and more water soluble compounds.	Water	217-222	glutathione S-transferase kappa 1	Homo sapiens	42-46
25209743-4	2015	Our results showed that treatment with UTI at a dose of 50,000 U/kg attenuated the brain edema, as assayed by water content 24 h after TBI induction.	Water	110-115	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	39-42
34022292-0	2021	Characterizing ligand-induced conformational changes in clinically relevant galectin-1 by HN/H2O (D2O) exchange.	Water	93-96	galectin 1	Homo sapiens	76-86
25683198-1	2015	It is generally believed that in vertebrates, prolactin (PRL) is predominantly synthesized and released by pituitary lactotrophs and plays important roles in many physiological processes via activation of PRL receptor (PRLR), including water and electrolyte balance, reproduction, growth and development, metabolism, immuno-modulation, and behavior.	Water	236-241	prolactin receptor	Gallus gallus	205-217
25683198-1	2015	It is generally believed that in vertebrates, prolactin (PRL) is predominantly synthesized and released by pituitary lactotrophs and plays important roles in many physiological processes via activation of PRL receptor (PRLR), including water and electrolyte balance, reproduction, growth and development, metabolism, immuno-modulation, and behavior.	Water	236-241	prolactin receptor	Gallus gallus	219-223
34022292-6	2021	The measurement of fast HN/H2O exchange by phase-modulated NMR clean chemical exchange (CLEANEX) NMR on 15N-labeled Gal-1 then increased the spatial resolution to the level of individual amino acids.	Water	27-30	galectin 1	Homo sapiens	116-121
26108786-12	2015	RVI requires the sequential activation of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and NKCC1, a Na(+) -K(+) -Cl(-) cotransporter, allowing ion entry and driving osmotic water flow.	Water	182-187	serine/threonine kinase 24	Homo sapiens	42-47
26108786-12	2015	RVI requires the sequential activation of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and NKCC1, a Na(+) -K(+) -Cl(-) cotransporter, allowing ion entry and driving osmotic water flow.	Water	182-187	solute carrier family 12 member 2	Homo sapiens	100-141
33961439-0	2021	Ultraeven Mo-Doped CoP Nanocrystals as Bifunctional Electrocatalyst for Efficient Overall Water Splitting.	Water	90-95	caspase recruitment domain family member 16	Homo sapiens	19-22
33961439-2	2021	The ordered arrangement of cations in the CoMo-LDH could be easily phosphored and generate the ultraevenly dispersed Mo element within the CoP structure, resulting in the excellent bifunctional catalyst for overall water splitting.	Water	215-220	caspase recruitment domain family member 16	Homo sapiens	139-142
26146957-0	2015	2D-GaS as a Photocatalyst for Water Splitting to Produce H2.	Water	30-35	gastrin	Homo sapiens	3-6
33999755-12	2021	The study may provide a new corridor to save the broad-spectrum water soluble pesticides which are on the verge to be banned.	Water	64-69	apolipoprotein L domain containing 1	Homo sapiens	106-111
26146957-2	2015	Here, simulations of adsorption of H2O on nanoscale GaS reveal that localized electronic states at its edges appear in the gap and strengthen the interaction with H2O, further activating the surface atomic sites.	Water	35-38	gastrin	Homo sapiens	52-55
26146957-2	2015	Here, simulations of adsorption of H2O on nanoscale GaS reveal that localized electronic states at its edges appear in the gap and strengthen the interaction with H2O, further activating the surface atomic sites.	Water	163-166	gastrin	Homo sapiens	52-55
26146957-3	2015	It is thus predicted that GaS synthesized with a controlled thickness and preferred edges may be an efficient catalyst for photocatalytic splitting of water.	Water	151-156	gastrin	Homo sapiens	26-29
33990323-1	2021	Ice-sheet responses to climate warming and associated sea-level rise depend sensitively on the form of the slip law that relates drag at the beds of glaciers to their slip velocity and basal water pressure.	Water	191-196	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	54-57
26266554-3	2015	According to the binding energies at the method of MP2/6-311++G(d,p), the total binding energies decrease with the increasing of the water molecules.	Water	133-138	tryptase pseudogene 1	Homo sapiens	51-54
33982417-0	2022	Estimating the Metals" Loading into the Sea from Tidal Rivers Using the TSS Concentrations and Water Quality Models.	Water	95-100	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	40-43
26132437-5	2015	The pentapeptide, acA5nme, where there are three intrapeptide backbone hydrogen bonds, shows a conformational free energy landscape with a much greater degree of sensitivity to the choice of solvent model, though the three rigid-body water models differ only quantitatively.	Water	234-239	small nucleolar RNA, H/ACA box 5A	Homo sapiens	18-22
33982417-5	2022	Thus, a method including the following five steps was proposed to estimate the loadings of metals entering the sea using TSS concentrations and water quality models: (1) collecting and observing the basic information of the hydrological conditions, pollution sources and water quality of the assessed river; (2) identifying a regression model between the four forms of suspended metals and the total suspended solids and analyzing the potential of using TSS concentrations and water quality models to estimate the loadings of suspended metals entering the sea; (3) simulating the process of dissolved metals in the studied river using an introduced water quality model; (4) presenting the migration and transformation process of suspended metals by simulating TSS transport in the studied river; and (5) characterizing the fluxes of the five forms of metals into the sea through the studied tidal river.	Water	144-149	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	111-114
33938239-8	2021	Expression analysis of the principal proteins involved in the generation of the cortico-medullary osmotic gradient and the resultant movement of water identified misexpression of Aquaporin-2 in the inner medullary collecting duct as the possible cause for the inability of young adult Ksp-cadherin deficient animals to maximally concentrate their urine.	Water	145-150	aquaporin 2	Mus musculus	179-190
26158561-2	2015	We employ a combination of molecular dynamics (MD) simulations and dynamical force-spectroscopy experiments based on atomic force microscopy (AFM) to estimate the free energy of adsorption DeltaGads of a (GCRL) tetrapeptide on amorphous SiO2 in pure water.	Water	250-255	nuclear receptor subfamily 3 group C member 1 pseudogene 1	Homo sapiens	205-209
33942258-13	2021	The first principal component (PC1) accounting for 30.70% of the total variance correlated significantly with soil pH (H2O), contents of CaCO3, Na, Ca, 40K, and 226Ra in soil, as well as with 226Ra, Na, Ca in plants and TFCa.	Water	119-122	proprotein convertase subtilisin/kexin type 1	Homo sapiens	31-34
26084697-1	2015	Predicated on evidence that diving-related microparticle generation is an oxidative stress response, this study investigated the role that oxygen plays in augmenting production of annexin V-positive microparticles associated with open-water SCUBA diving and whether elevations can be abrogated by ascorbic acid.	Water	235-240	annexin A5	Homo sapiens	180-189
33933702-3	2021	One of them is aquaporin-3 (AQP3), which is a small, hydrophobic, integral membrane protein with a predominant role in water and glycerol transport.	Water	119-124	aquaporin 3 (Gill blood group)	Homo sapiens	15-26
25935419-0	2015	A novel water-soluble benzothiazole derivative BD926 inhibits human activated T cell proliferation by down-regulating the STAT5 activation.	Water	8-13	signal transducer and activator of transcription 5A	Homo sapiens	122-127
33933702-3	2021	One of them is aquaporin-3 (AQP3), which is a small, hydrophobic, integral membrane protein with a predominant role in water and glycerol transport.	Water	119-124	aquaporin 3 (Gill blood group)	Homo sapiens	28-32
33949975-3	2021	Enoyl-CoA hydratase (ECH) catalyzes the second step of the beta-oxidation pathway by the syn addition of water to the double bond between C2 and C3 of a 2-trans-enoyl-CoA, resulting in the formation of a 3-hydroxyacyl CoA.	Water	105-110	enoyl-CoA hydratase/isomerase family protein	Thermus thermophilus HB8	0-19
26550426-10	2015	CONCLUSION: The water solubility of GLA significantly increased in combination with gamma-CD resulting in the production of GLA-gamma-CD.	Water	16-21	galactosidase, alpha	Mus musculus	36-39
26550426-10	2015	CONCLUSION: The water solubility of GLA significantly increased in combination with gamma-CD resulting in the production of GLA-gamma-CD.	Water	16-21	galactosidase, alpha	Mus musculus	124-127
33946459-0	2021	Synthesis and Evaluation of the Cytotoxic Activity of Water-Soluble Cationic Organometallic Complexes of the Type [Pt(eta1-C2H4OMe)(L)(Phen)]+ (L = NH3, DMSO; Phen = 1,10-Phenanthroline).	Water	54-59	secreted phosphoprotein 1	Homo sapiens	118-122
25982564-4	2015	Furthermore, we used a rat model of TBI to show that increased TDP-43 proteolysis following TBI produces FTD-like impairments, including abnormal limb-clasping, and impaired performances in the Morris water maze.	Water	201-206	TAR DNA binding protein	Rattus norvegicus	63-69
33946459-5	2021	Differently, the [Pt(eta1-C2H4OMe)(DMSO)(phen)]+ (3) complex was easily hydrolyzed in neutral water, resulting in a comparable or higher cytotoxicity in cancer cells with respect to cisplatin.	Water	94-99	secreted phosphoprotein 1	Homo sapiens	21-25
33910638-4	2021	RESULTS: Higher levels of lncRNA score and PVT1 expression were associated with increased serum calcium level after water ingestion and PC risk (P < 0.05).	Water	116-121	Pvt1 oncogene	Homo sapiens	43-47
26166150-1	2015	A method for analysis of hop-derived polyfunctional thiols, such as 4-sulfanyl-4-methylpentan-2-one (4S4M2Pone), 3-sulfanylhexan-1-ol (3SHol), and 3-sulfanylhexyl acetate (3SHA), in beer, hop water extract, and wort at nanogram per liter levels was developed.	Water	192-197	HOP homeobox	Homo sapiens	25-28
33847477-8	2021	In addition, FEN1 can be visualized not only by colorimetry but also by fluorescence (under ice-water mixture conditions).	Water	96-101	flap structure-specific endonuclease 1	Homo sapiens	13-17
33925339-9	2021	Additionally, we found that RDR6 and SGS3 are involved in the production of smRNAs that target transcripts related to abiotic stresses, including water deprivation, salt stress, and ABA response, and as expected the levels of these mRNAs are increased in rdr6 and sgs3 mutant plants.	Water	146-151	RNA-dependent RNA polymerase 6	Arabidopsis thaliana	28-32
26074243-14	2015	Conductively cooling the cows with 4.5 C water decreased rectal temperature by 1.0 C, decreased respiration rate by 18 breaths/min, increased milk yield by 5%, and increased DMI by 14% compared with the controls.	Water	41-46	DMI	Bos taurus	174-177
33925339-9	2021	Additionally, we found that RDR6 and SGS3 are involved in the production of smRNAs that target transcripts related to abiotic stresses, including water deprivation, salt stress, and ABA response, and as expected the levels of these mRNAs are increased in rdr6 and sgs3 mutant plants.	Water	146-151	XS domain-containing protein / XS zinc finger domain-containing protein-like protein	Arabidopsis thaliana	37-41
33932887-5	2021	PEGylated RB (termed as RBP) were further synthesized to improve the water solubility and prolong blood circulation by the click reaction of propiolate-terminated RB with amino terminated poly(ethylene glycol) (PEG-NH2).	Water	69-74	SURP and G-patch domain containing 1	Homo sapiens	24-27
33749266-1	2021	The hydration thermodynamics of different mutants of alpha-synuclein (alpha-syn) related to familial Parkinson"s disease (PD) is explored using a computational approach that combines both molecular dynamics simulations in water and integral equation theory of molecular liquids.	Water	222-227	synuclein alpha	Homo sapiens	53-68
33749266-1	2021	The hydration thermodynamics of different mutants of alpha-synuclein (alpha-syn) related to familial Parkinson"s disease (PD) is explored using a computational approach that combines both molecular dynamics simulations in water and integral equation theory of molecular liquids.	Water	222-227	synuclein alpha	Homo sapiens	53-62
33582135-11	2021	Additionally, our simulations reveal that upon opening, water molecules occupy lateral fenestrations in the cytosolic region of Piezo1 which might be likely paths for ion permeation.	Water	56-61	piezo type mechanosensitive ion channel component 1	Homo sapiens	128-134
33918591-1	2021	This study examined the rate of injuries and chronic pain in collegiate water-ski athletes as a preliminary study.	Water	72-77	SKI proto-oncogene	Homo sapiens	78-81
25582782-7	2015	The empirical relationships between the organic-carbon normalized sorption coefficient (Koc) and water solubility and between Koc and the octanol-water partition coefficient (Kow) were established.	Water	97-102	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	88-91
25582782-7	2015	The empirical relationships between the organic-carbon normalized sorption coefficient (Koc) and water solubility and between Koc and the octanol-water partition coefficient (Kow) were established.	Water	146-151	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	126-129
33918591-3	2021	A total number of 96 collegiate water-ski athletes, aged 21.4 +- 2.23 years, participated in the study.	Water	32-37	SKI proto-oncogene	Homo sapiens	38-41
25750752-4	2015	Under water stress, Sids had higher membrane stability index (MSI), lower accumulated H2O2 and higher activity of the antioxidant enzymes; catalase (CAT), guaiacol peroxidase (GPX), ascorbate peroxidase (APX) and superoxide dismutase (SOD) than Gmiza.	Water	6-11	catalase-1	Triticum aestivum	139-147
25750752-4	2015	Under water stress, Sids had higher membrane stability index (MSI), lower accumulated H2O2 and higher activity of the antioxidant enzymes; catalase (CAT), guaiacol peroxidase (GPX), ascorbate peroxidase (APX) and superoxide dismutase (SOD) than Gmiza.	Water	6-11	catalase-1	Triticum aestivum	149-152
33898501-1	2021	Fubaiju Hot-Water Extracts Against ARPE-19 Cell Oxidative Damage by Activating PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway.	Water	12-17	heme oxygenase 1	Homo sapiens	102-106
33439102-0	2021	Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement via IL-10 and Sirt 1 signaling.	Water	14-19	sirtuin 1	Mus musculus	112-118
32262421-3	2015	The colloidal stability of functionalized NS10 has been evaluated in water and in different physiological media.	Water	69-74	leucine zipper like transcription regulator 1	Homo sapiens	42-46
25686321-4	2015	Activation of TRPV1 increased the intracellular Ca(2+) concentration, upregulated the expression of aquaporin 5 (AQP5), the main transporter that mediate water secretion through transcellular pathway, and led to AQP5 redistribution.	Water	154-159	aquaporin 5	Homo sapiens	100-111
33648644-3	2021	After an optimization protocol, the biosensor achieved a limit of detection (LOD) of 0.29 ng mL-1 (1.05 nM) and a half-maximal inhibitory concentration (IC50) of 1.71 ng mL-1 (6.09 nM) using a competitive immunoassay and employing diluted tap water.	Water	243-248	L1 cell adhesion molecule	Mus musculus	93-97
25686321-4	2015	Activation of TRPV1 increased the intracellular Ca(2+) concentration, upregulated the expression of aquaporin 5 (AQP5), the main transporter that mediate water secretion through transcellular pathway, and led to AQP5 redistribution.	Water	154-159	aquaporin 5	Homo sapiens	113-117
33648644-3	2021	After an optimization protocol, the biosensor achieved a limit of detection (LOD) of 0.29 ng mL-1 (1.05 nM) and a half-maximal inhibitory concentration (IC50) of 1.71 ng mL-1 (6.09 nM) using a competitive immunoassay and employing diluted tap water.	Water	243-248	L1 cell adhesion molecule	Mus musculus	170-174
33582182-2	2021	Aquaporin 5 (AQP5) represents an essential membrane water channel.	Water	52-57	aquaporin 5	Homo sapiens	13-17
25046564-5	2015	The loop-close form is relatively tight in space, which squeezes water molecules out of the interface of alpha-helix and beta2 strand, joined by the connecting loop region; accordingly, the water-scant environment leads to the sole existence of the N(1)-H isomer emission.	Water	65-70	neuronal differentiation 1	Homo sapiens	121-126
25046564-5	2015	The loop-close form is relatively tight in space, which squeezes water molecules out of the interface of alpha-helix and beta2 strand, joined by the connecting loop region; accordingly, the water-scant environment leads to the sole existence of the N(1)-H isomer emission.	Water	190-195	neuronal differentiation 1	Homo sapiens	121-126
33609527-6	2021	Similarly, GPER1 activation, via G1, prevented males from forming a preference for 0.1% saccharin (SACC) versus plain water.	Water	118-123	G protein-coupled estrogen receptor 1	Rattus norvegicus	11-16
25238557-0	2015	Electrostatically assembled CdS-Co3 O4 nanostructures for photo-assisted water oxidation and photocatalytic reduction of dye molecules.	Water	73-78	CDP-diacylglycerol synthase 1	Homo sapiens	28-31
25238557-1	2015	Electrostatic assembly is used here to couple CdS nanorods with Co3 O4 nanoparticles into photocatalytic systems that simultaneously oxidize water and mediate electron transfer.	Water	141-146	CDP-diacylglycerol synthase 1	Homo sapiens	46-49
33837053-1	2021	BACKGROUND: OH2 is a genetically engineered oncolytic herpes simplex virus type 2 designed to selectively amplify in tumor cells and express granulocyte-macrophage colony-stimulating factor to enhance antitumor immune responses.	Water	12-15	colony stimulating factor 2	Homo sapiens	141-189
25380566-5	2015	Ultrastructural analysis revealed that Kir4.1-immunogold particles were specifically localized and clustered on adjacent membranes at puncta adherens type junctions, whereas an aquaporin water channel, AQP4, that was also detected on the lateral membrane only occurred at components other than adherens junctions.	Water	187-192	aquaporin 4	Rattus norvegicus	202-206
25380566-6	2015	Therefore, in ependymal cells, Kir4.1 and AQP4 are partitioned into distinct membrane compartments that might respectively transport either K(+) or water.	Water	148-153	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	31-37
25380566-6	2015	Therefore, in ependymal cells, Kir4.1 and AQP4 are partitioned into distinct membrane compartments that might respectively transport either K(+) or water.	Water	148-153	aquaporin 4	Rattus norvegicus	42-46
33500062-5	2021	The quantitative and qualitative output of MEF is significantly affected by: (a) conditions of the process in the reactor: the gas pressure, its flow rate, temperature, amperage; the distance between the electrodes, and others, that is, those factors that determine the plasma temperature and the residence time of the reaction particles in it; (b) the composition of solid additives (salts, oxides, metal alloys) in the graphite anode and their quantitative (mol) ratio with carbon; (c) replacement of the inert atmosphere of the synthesis with the active one (helium-with nitrogen, ammonia, water vapor, CO and other gases).	Water	593-598	E74 like ETS transcription factor 4	Homo sapiens	43-46
25529427-2	2015	Of the aquaporins (AQP), which are a family of membrane-spanning proteins that are predominantly involved in the movement of water, AQP-3, AQP-7, and AQP-10 are also permeable to urea, but it is not clear if they contribute to urea transport across the ruminal epithelium.	Water	125-130	aquaporin 10	Bos taurus	150-156
25574837-6	2015	Mice lacking HIF2alpha in ECs had increased lung vascular permeability and water content, both of which were further exacerbated by endotoxin-mediated injury.	Water	75-80	endothelial PAS domain protein 1	Mus musculus	13-22
33511696-2	2021	Under optimal conditions, the linear response range of the analytes for water sample is 0.25-50 ng mL-1 with the correlation coefficients (r) ranging between 0.9953 and 0.9996.	Water	72-77	L1 cell adhesion molecule	Mus musculus	99-103
24929663-2	2015	During ischemia the extracellular K(+) concentration increases to very high levels, which when energy becomes available during reperfusion stimulate NKCC1, a cotransporter driven by the transmembrane ion gradients established by the Na(+),K(+)-ATPase and accumulating Na(+), K(+) and 2 Cl(-) together with water.	Water	306-311	solute carrier family 12 member 2	Homo sapiens	149-154
33244801-9	2021	By using pSLN and T18A, our study provides helpful information on the pore-forming mechanism of SLN and furthers our understanding of the regulatory mechanisms underlying the permeation of ions and water molecules in the pentameric SLN channel.	Water	198-203	sarcolipin	Homo sapiens	10-13
25556693-7	2015	Quite importantly and in contrast to widely used encapsulation strategies, rHSA NP surface-attached (CeLn)(3/4+)-gamma-Fe2O3 NPs enabled to exploit both rHSA (protein functionalities) and (CeLn)(3/4+)-gamma-Fe2O3 NP surface functionalities (COOH and ligand L coordinative exchange) in addition to very effective MRI contrast capability due to optimal accessibility of H2O molecules with the outer magnetic phase.	Water	368-371	CD24 molecule	Rattus norvegicus	75-79
33244801-9	2021	By using pSLN and T18A, our study provides helpful information on the pore-forming mechanism of SLN and furthers our understanding of the regulatory mechanisms underlying the permeation of ions and water molecules in the pentameric SLN channel.	Water	198-203	sarcolipin	Homo sapiens	96-99
33625484-0	2021	Sea foams are ephemeral hotspots for distinctive bacterial communities contrasting sea-surface microlayer and underlying surface water.	Water	129-134	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
25439867-6	2015	When the hydrolysis of cellulose was catalyzed by 1-propyl sulfonic acid-2-phenyl imidazoline hydrogensulfate (IL-1) and the dosage of water was 0.2g, the TRS yield was up to 85.1% within 60 min at 100 C. These new acidic ionic liquids catalysts are expected to have a wide application in the conversion of cellulose into valuable chemicals.	Water	135-140	interleukin 1 alpha	Homo sapiens	111-115
33217517-15	2021	Western blot assays showed that PRLR, STAT5alpha and cyclin D1 levels in the mammary glands of the raw HFG water decoction group were significantly increased, which was consistent with the results of cDNA microarray screening.	Water	107-112	prolactin receptor	Rattus norvegicus	32-36
25486065-1	2015	A novel derivatization method of free cyanide (HCN + CN(-)) including cyanogen chloride in chlorinated drinking water was developed with d-cysteine and hypochlorite.	Water	112-117	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	47-50
33484489-0	2021	Interface Engineering of Needle-Like P-Doped MoS2/CoP Arrays as Highly Active and Durable Bifunctional Electrocatalyst for Overall Water Splitting.	Water	131-136	caspase recruitment domain family member 16	Homo sapiens	50-53
25412148-4	2015	Simulation results show that lipase is strongly adsorbed onto the hydrophobic graphite surface, as reflected by the large contact area and interaction energy; while the adsorption onto the hydrophilic TiO2 surface is weak due to two strongly adhered water layers; meanwhile lipase undergoes desorption and reorientation processes.	Water	250-255	PAN0_003d1715	Moesziomyces antarcticus	29-35
33898275-7	2021	These nanocomposites were used for the adsorption of highly toxic metals such as Cd2+, Pb2+ and Zn2+ in water.	Water	104-109	CD2 molecule	Homo sapiens	81-84
24875192-4	2015	The central role of principal cells in salt and water transport is reflected by their defining transporters-the epithelial Na(+) channel (ENaC), the renal outer medullary K(+) channel, and the aquaporin 2 (AQP2) water channel.	Water	212-217	aquaporin 2	Homo sapiens	206-210
33898275-12	2021	Chitosan, carboxymethyl cellulose, alginate and lignin based nanocomposites have demonstrated better adsorption activities due to great physical and chemical properties for the chelation of heavy metals such as Cd2+, Pb2+ and Zn2+ from water and also higher regeneration with various eluents after several desorption-adsorption cycles.	Water	236-241	CD2 molecule	Homo sapiens	211-214
33727239-10	2021	There were differences in the presentation between children with accidental scalds and the 103 who were referred for CP assessment; children with scalds caused by hot water in baths/showers were more likely to get referred for CP assessment (p<0.0001), as were those with symmetrically distributed (p<0.0001) and unwitnessed (p=0.007) scalds.	Water	167-172	ceruloplasmin	Homo sapiens	227-229
25573553-0	2015	Accurate vibrational spectra via molecular tailoring approach: a case study of water clusters at MP2 level.	Water	79-84	tryptase pseudogene 1	Homo sapiens	97-100
25936678-10	2015	TM significantly decreased brain water content and Evans Blue content, alleviated brain edema and neurological deficits after SAH.	Water	33-38	thrombomodulin	Mus musculus	0-2
26132113-2	2015	The photoanode is constituted by an organic dye L0 as photosensitizer and a molecular complex Ru1 as water oxidation catalyst on meso-porous TiO2, while the photocathode is constructed with an organic dye P1 as photoabsorber and a molecular complex Co1 as hydrogen generation catalyst on nanostructured NiO.	Water	101-106	Scm like with four mbt domains 1	Homo sapiens	94-97
26203135-8	2015	Endogenous PI3Kgamma levels were increased within peri-resection brain tissues after SBI, accompanied by increased brain water content and neurological functional deficits.	Water	121-126	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	11-20
25714979-7	2015	Our results suggested that treatment with these different extract fractions from AGR could ameliorate cognitive impairment and down-regulate expressions of doublecortin and nestin in the hippocampus of Abeta1-42 injected mice, in which water extract and volatile oil fractions were more effective in spatial memory than defatted decoction fraction.	Water	236-241	doublecortin	Mus musculus	156-168
32835415-8	2021	Water holding capacity increased significantly by 32.33% in the presence of 0.10% kappa-CAR addition.	Water	0-5	CXADR pseudogene 1	Homo sapiens	88-91
25454229-3	2015	The aim of this study was to determine the presence of endocrine activities dependent on the activation of human estrogen receptor alpha (hERa) and/or androgen receptor (hAR) in water in glass or plastic bottles sold to consumers in Southern Spain.	Water	178-183	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	170-173
25978950-13	2015	CONCLUSIONS: Fructus Ligustri Lucidi water extract promoted cell proliferation and differentiation, mRNA and protein expression of OPG and RANKL on MC3T3-E1 cells.	Water	37-42	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	139-144
32839982-3	2021	RESULTS: The water solubility of oleuropein was determined, resulting in 9.5 g L-1 .	Water	13-18	L1 cell adhesion molecule	Mus musculus	79-82
25527214-1	2015	Pegylated zinc protoporphyrin (PEG-ZnPP) is a water-soluble inhibitor of heme oxygenase-1.	Water	46-51	heme oxygenase 1	Homo sapiens	73-89
33340741-5	2021	These deep-water sea states were propagated using a numerical model (Delft3D-Wave) and results were obtained at 176 locations.	Water	11-16	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	17-20
25898645-2	2015	The results were listed as follows, when Xiaolangdi Reservoir operated normally, pCO2 in surface water of Xiaolangdi station and Huayuankou station varied from 82 to 195 Pa and from 99 to 228 Pa, moreover, pCO2 in surface water from July to September were distinctly higher than those in other months; meanwhile, pCO, in surface water from Huayuankou station were higher than that from Xiaolangdi station.	Water	97-102	PCOS1	Homo sapiens	81-84
25898645-2	2015	The results were listed as follows, when Xiaolangdi Reservoir operated normally, pCO2 in surface water of Xiaolangdi station and Huayuankou station varied from 82 to 195 Pa and from 99 to 228 Pa, moreover, pCO2 in surface water from July to September were distinctly higher than those in other months; meanwhile, pCO, in surface water from Huayuankou station were higher than that from Xiaolangdi station.	Water	222-227	PCOS1	Homo sapiens	81-84
26028490-1	2015	Efficient direct synthesis of macrodiolides via catalysis using Hf(OTf)4 is possible in high yields, forming water as the sole by-product.	Water	109-114	POU class 5 homeobox 1	Homo sapiens	67-72
33348096-4	2021	Fluorescence detection of Pd2+ in practical water sample was also successfully achieved.	Water	44-49	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	26-29
25663339-5	2015	Dissolved oxygen (DO) in the water reduced the 2,4-DNT degradation and the formation of 2,4-DAT.	Water	29-34	5', 3'-nucleotidase, cytosolic	Homo sapiens	51-54
25898645-2	2015	The results were listed as follows, when Xiaolangdi Reservoir operated normally, pCO2 in surface water of Xiaolangdi station and Huayuankou station varied from 82 to 195 Pa and from 99 to 228 Pa, moreover, pCO2 in surface water from July to September were distinctly higher than those in other months; meanwhile, pCO, in surface water from Huayuankou station were higher than that from Xiaolangdi station.	Water	222-227	PCOS1	Homo sapiens	81-84
33748602-1	2021	Produced water (PW) is the water associated with hydrocarbons during the extraction of oil and gas (O&G) from either conventional or unconventional resources.	Water	9-14	gastrin	Homo sapiens	95-98
25450547-0	2015	Effect of water-soluble chitosan in combination with glutathione on the quality of pen shell adductor muscles.	Water	10-15	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	83-86
26086045-4	2015	These sea level rise scenarios lead to increased frequency of high water coastal events.	Water	67-72	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	6-9
33310621-5	2021	There is a good linear relationship between fluorescence intensity of PDS and Co2+ concentration within 0-20 muM, and its detection limt was found to be 0.925 muM, which is far lower than the national standard for cobalt in drinking water in China.	Water	233-238	complement C2	Homo sapiens	78-81
26086045-8	2015	The model results show an increased likelihood of extreme sea level events through the 21st century, with the frequency of events increasing greatly in the second half of the century: water levels that occurred at decadal time intervals under present-day model conditions occurred in most years by the middle of the 21st century and 3-15 times per year by 2100.	Water	184-189	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	58-61
25313470-7	2015	It is assumed that this transition involves the removal of PEO3 chains from the water surface in case of non-symmetric PEO12-b-PIB85-b-PEO3 and in case of symmetric, probably one PEO3 of each PEO3-b-PIB85-b-PEO3 chain.	Water	80-85	solute carrier family 25 member 4	Homo sapiens	59-63
33310621-7	2021	The probe PDS was also successfully applied in detection of Co2+ in tap water and fresh vegetables.	Water	72-77	complement C2	Homo sapiens	60-63
25313470-7	2015	It is assumed that this transition involves the removal of PEO3 chains from the water surface in case of non-symmetric PEO12-b-PIB85-b-PEO3 and in case of symmetric, probably one PEO3 of each PEO3-b-PIB85-b-PEO3 chain.	Water	80-85	solute carrier family 25 member 4	Homo sapiens	135-139
25313470-7	2015	It is assumed that this transition involves the removal of PEO3 chains from the water surface in case of non-symmetric PEO12-b-PIB85-b-PEO3 and in case of symmetric, probably one PEO3 of each PEO3-b-PIB85-b-PEO3 chain.	Water	80-85	solute carrier family 25 member 4	Homo sapiens	135-139
26093555-0	2015	An accurate and efficient computational protocol for obtaining the complete basis set limits of the binding energies of water clusters at the MP2 and CCSD(T) levels of theory: Application to (H2O)m, m = 2-6, 8, 11, 16, and 17.	Water	120-125	tryptase pseudogene 1	Homo sapiens	142-145
26093555-7	2015	Based on those findings, we propose an accurate and efficient computational protocol that can be presently used to estimate accurate binding energies of water clusters containing up to 30 molecules (for CCSD(T)) and up to 100 molecules (for MP2).	Water	153-158	tryptase pseudogene 1	Homo sapiens	241-244
25313470-7	2015	It is assumed that this transition involves the removal of PEO3 chains from the water surface in case of non-symmetric PEO12-b-PIB85-b-PEO3 and in case of symmetric, probably one PEO3 of each PEO3-b-PIB85-b-PEO3 chain.	Water	80-85	solute carrier family 25 member 4	Homo sapiens	135-139
33711796-7	2021	Pilot scale experiments show that this novel sorbent is capable of capturing 31.8 kg P t-1 from sludge water that contains 52.5 mg of extractable P L-1.	Water	103-108	zinc finger protein 77	Homo sapiens	85-90
25313470-7	2015	It is assumed that this transition involves the removal of PEO3 chains from the water surface in case of non-symmetric PEO12-b-PIB85-b-PEO3 and in case of symmetric, probably one PEO3 of each PEO3-b-PIB85-b-PEO3 chain.	Water	80-85	solute carrier family 25 member 4	Homo sapiens	135-139
25313470-8	2015	Because of the weaker interaction of the short PEO3 chains with the water surface as compared with the relatively longer PEO12 chains, the film of PEO3-b-PIB85-b-PEO3 collapses at much lower surface pressure after the transition as compared with the PEO12-b-PIB85-b-PEO3.	Water	68-73	solute carrier family 25 member 4	Homo sapiens	47-51
25313470-8	2015	Because of the weaker interaction of the short PEO3 chains with the water surface as compared with the relatively longer PEO12 chains, the film of PEO3-b-PIB85-b-PEO3 collapses at much lower surface pressure after the transition as compared with the PEO12-b-PIB85-b-PEO3.	Water	68-73	solute carrier family 25 member 4	Homo sapiens	147-151
25313470-8	2015	Because of the weaker interaction of the short PEO3 chains with the water surface as compared with the relatively longer PEO12 chains, the film of PEO3-b-PIB85-b-PEO3 collapses at much lower surface pressure after the transition as compared with the PEO12-b-PIB85-b-PEO3.	Water	68-73	solute carrier family 25 member 4	Homo sapiens	147-151
25313470-8	2015	Because of the weaker interaction of the short PEO3 chains with the water surface as compared with the relatively longer PEO12 chains, the film of PEO3-b-PIB85-b-PEO3 collapses at much lower surface pressure after the transition as compared with the PEO12-b-PIB85-b-PEO3.	Water	68-73	solute carrier family 25 member 4	Homo sapiens	147-151
25974045-3	2015	Thermal transitions of alpha-lactalbumin and beta-lactoglobulin components of BWP included water-content-dependent endothermic but reversible dehydration and denaturation, and exothermic and irreversible aggregation.	Water	91-96	lactalbumin alpha	Bos taurus	23-40
25817866-1	2015	The Na(+)/multivitamin transporter (SMVT) is a member of the solute:sodium symporter family that catalyzes the Na(+)-dependent uptake of the structurally diverse water-soluble vitamins pantothenic acid (vitamin B5) and biotin (vitamin H), alpha-lipoic acid-a vitamin-like substance with strong antioxidant properties-and iodide.	Water	162-167	solute carrier family 5 member 6	Homo sapiens	36-40
33648000-4	2021	By inhibiting the SGLT2 transporter in the proximal tubule of the kidneys, energy and water are continuously excreted and metabolic processes that are counter-regulated are set in motion.	Water	86-91	solute carrier family 5 member 2	Homo sapiens	18-23
25817873-2	2015	Vasopressin increases the apical water permeability of principal cells, mediated by apical accumulation of aquaporin-2 (AQP2), a water channel protein, thus facilitating water reabsorption by the kidney.	Water	33-38	aquaporin 2	Homo sapiens	107-118
25817873-2	2015	Vasopressin increases the apical water permeability of principal cells, mediated by apical accumulation of aquaporin-2 (AQP2), a water channel protein, thus facilitating water reabsorption by the kidney.	Water	33-38	aquaporin 2	Homo sapiens	120-124
25817873-2	2015	Vasopressin increases the apical water permeability of principal cells, mediated by apical accumulation of aquaporin-2 (AQP2), a water channel protein, thus facilitating water reabsorption by the kidney.	Water	129-134	aquaporin 2	Homo sapiens	107-118
25817873-2	2015	Vasopressin increases the apical water permeability of principal cells, mediated by apical accumulation of aquaporin-2 (AQP2), a water channel protein, thus facilitating water reabsorption by the kidney.	Water	129-134	aquaporin 2	Homo sapiens	120-124
25817873-2	2015	Vasopressin increases the apical water permeability of principal cells, mediated by apical accumulation of aquaporin-2 (AQP2), a water channel protein, thus facilitating water reabsorption by the kidney.	Water	129-134	aquaporin 2	Homo sapiens	107-118
25817873-2	2015	Vasopressin increases the apical water permeability of principal cells, mediated by apical accumulation of aquaporin-2 (AQP2), a water channel protein, thus facilitating water reabsorption by the kidney.	Water	129-134	aquaporin 2	Homo sapiens	120-124
25916278-8	2015	RESULTS: Spinal cord water content was obviously increased after SCI, which was maintained almost unchanged by melatonin treatment (100 mg/kg) at 12 h after injury but was significantly reduced from 24 h to 72 h. The expressions of AQP4 and GFAP increased in the injured spinal cord segments, which were decreased by melatonin treatment (100 mg/kg) between 24 h and 72 h after SCI.	Water	21-26	aquaporin 4	Rattus norvegicus	232-236
25692851-3	2015	The revised dynamic, process-based INCA model was used to simulate hydrology and water quality within the complex multi-branched river basins.	Water	81-86	caspase recruitment domain family member 17	Homo sapiens	35-39
33650048-2	2021	The objectives of this study were to determine if the levels of serum CC16 and MMP-9 and subsequent respiratory infections in children are associated with the ingestion of arsenic by drinking water.	Water	192-197	secretoglobin family 1A member 1	Homo sapiens	70-74
25820241-5	2015	Compared with the parent drug (PTX), OCT(Phe)-PEG-PTX, and mPEG-PTX prodrugs showed a 20,000- and 30,000-fold increase in water solubility, respectively.	Water	122-127	plexin A2	Homo sapiens	37-40
25453083-10	2014	We propose a catalytic mechanism for DHFR that involves stabilization of the keto tautomer of the substrate, elevation of the pKa value of the N5 atom of DHF by Asp27, and protonation of N5 by water that gains access to the active site through fluctuation of the Met20 side chain even though the Met20 loop is closed.	Water	193-198	Dihydrofolate reductase	Escherichia coli	37-41
33650048-7	2021	Increased arsenic concentrations in drinking water and average daily arsenic intake by water were associated with decreased serum CC16 levels (beta = - 0.12, 95% CI - 0.20, - 0.04 and beta = - 0.10, 95% CI - 0.18, - 0.03), and increased serum MMP-9 levels (beta = 0.35, 95% CI 0.22, 0.48 and beta = 0.29, 95% CI 0.18, 0.40) at significant levels (P < 0.05).	Water	45-50	secretoglobin family 1A member 1	Homo sapiens	130-134
25999615-0	2015	Determination of the Polymer-Solvent Interaction Parameter for PEG Hydrogels in Water: Application of a Self Learning Algorithm.	Water	80-85	progestagen associated endometrial protein	Homo sapiens	63-66
33650048-7	2021	Increased arsenic concentrations in drinking water and average daily arsenic intake by water were associated with decreased serum CC16 levels (beta = - 0.12, 95% CI - 0.20, - 0.04 and beta = - 0.10, 95% CI - 0.18, - 0.03), and increased serum MMP-9 levels (beta = 0.35, 95% CI 0.22, 0.48 and beta = 0.29, 95% CI 0.18, 0.40) at significant levels (P < 0.05).	Water	87-92	secretoglobin family 1A member 1	Homo sapiens	130-134
33650048-10	2021	In conclusion, altered levels of serum CC16 and MMP-9 in the children may be due to the toxic effects of arsenic exposure through drinking water.	Water	139-144	secretoglobin family 1A member 1	Homo sapiens	39-43
25428372-8	2014	The conformations of these binding pockets include direct binding through desolvated ion bridges in the GpC steps in B-DNA and A-RNA; direct binding to backbone oxygens; binding of Mg[(H2O)6](2+) to distant phosphates, resulting in acute bending of A-RNA; tight "ion traps" in Z-RNA between C-O2 and the C-O2" atoms in GpC steps; and others.	Water	185-188	complement C2	Homo sapiens	291-295
33513284-3	2021	An ATP hydrolysis mechanism involving two water molecules has been proposed based on the structure of the kinesin-5 Eg5 bound to an ATP analog.	Water	42-47	kinesin family member 11	Homo sapiens	116-119
25428372-8	2014	The conformations of these binding pockets include direct binding through desolvated ion bridges in the GpC steps in B-DNA and A-RNA; direct binding to backbone oxygens; binding of Mg[(H2O)6](2+) to distant phosphates, resulting in acute bending of A-RNA; tight "ion traps" in Z-RNA between C-O2 and the C-O2" atoms in GpC steps; and others.	Water	185-188	complement C2	Homo sapiens	304-308
25766885-1	2015	Aquaporin-3 (AQP3) is a water channel that is predominantly expressed in the colon, where it plays a critical role in the regulation of fecal water content.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
25766885-1	2015	Aquaporin-3 (AQP3) is a water channel that is predominantly expressed in the colon, where it plays a critical role in the regulation of fecal water content.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
25766885-1	2015	Aquaporin-3 (AQP3) is a water channel that is predominantly expressed in the colon, where it plays a critical role in the regulation of fecal water content.	Water	142-147	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
25766885-1	2015	Aquaporin-3 (AQP3) is a water channel that is predominantly expressed in the colon, where it plays a critical role in the regulation of fecal water content.	Water	142-147	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
25766885-12	2015	The results suggest that morphine increases the AQP3 expression level in the colon, which promotes water absorption from the luminal side to the vascular side and causes constipation.	Water	99-104	aquaporin 3 (Gill blood group)	Homo sapiens	48-52
33338791-6	2021	50% of the variation in the CH2Br2 and CCl4 concentrations, which corresponded with increased CH2Br2 and CCl4 concentrations in the less saline water mass.	Water	144-149	C-C motif chemokine ligand 4	Homo sapiens	39-43
33338791-6	2021	50% of the variation in the CH2Br2 and CCl4 concentrations, which corresponded with increased CH2Br2 and CCl4 concentrations in the less saline water mass.	Water	144-149	C-C motif chemokine ligand 4	Homo sapiens	105-109
33338791-7	2021	Anthropogenic CCl4 was found with an average concentration of 44.9 pmol/L, and there was a strong positive relationship between CCl4 and CHCl3 in the upper water, indicating their similar source of pollutant transport caused by anthropogenic activities.	Water	156-161	C-C motif chemokine ligand 4	Homo sapiens	128-132
25996685-2	2015	We report here, the use of water soluble poly lactic-co-glycolic acid (PLGA)-encapsulated curcumin and emetine nanoparticles (Cm-NPs and Em-NPs, respectively), as potential modulators of gelsolin amyloidogenesis.	Water	27-32	gelsolin	Homo sapiens	187-195
33671048-3	2021	Here, comparing water and alcohol exposed msP and Wistar rats we evaluate the transcript expression of the anti-stress opioid-like peptide nociceptin/orphanin FQ (N/OFQ) and its receptor NOP as well as of dynorphin (DYN) and its cognate kappa-opioid receptor (KOP).	Water	16-21	prepronociceptin	Rattus norvegicus	139-149
33671048-3	2021	Here, comparing water and alcohol exposed msP and Wistar rats we evaluate the transcript expression of the anti-stress opioid-like peptide nociceptin/orphanin FQ (N/OFQ) and its receptor NOP as well as of dynorphin (DYN) and its cognate kappa-opioid receptor (KOP).	Water	16-21	prepronociceptin	Rattus norvegicus	150-161
25712145-0	2015	Interim anatase coating layer stabilizes rutile@Crx Oy photoanode for visible-light-driven water oxidation.	Water	91-96	cone-rod homeobox	Homo sapiens	48-51
33652869-2	2021	However, there is no experimental evidence to accurately determine the phase state of water during nanoscale gas hydrate dissociation.	Water	86-91	gastrin	Homo sapiens	109-112
25712145-1	2015	Ternary core-shell heterostructured rutile@anatase@Crx Oy nanorod arrays were elaborately designed as photoanodes for efficient photoelectrochemical water splitting under visible-light illumination.	Water	149-154	cone-rod homeobox	Homo sapiens	51-54
33668834-0	2021	Injuries Associated with the Practice of Calm Water Kayaking in the Canoeing Modality.	Water	46-51	synaptosome associated protein 91	Homo sapiens	41-45
25956102-1	2015	The influence of vibrational excitations in the partially deuterated water (HOD) reactant on its bond selective reactions with F is investigated using a full-dimensional quantum wave packet method on an accurate global potential energy surface.	Water	69-74	HOP homeobox	Homo sapiens	76-79
25956102-2	2015	Despite the decidedly early barrier of the F + H2O reaction, reactant vibrational excitation in each local stretching mode of HOD is found to significantly enhance the reaction which breaks the excited bond.	Water	47-50	HOP homeobox	Homo sapiens	126-129
33593893-4	2021	Here we show that the synaptic architecture of hippocampal regions CA1 and CA3 is maintained in a young adult-like state in aged rats that performed comparably to their young adult counterparts in both trace eyeblink conditioning and Morris water maze learning.	Water	241-246	carbonic anhydrase 1	Rattus norvegicus	67-70
25244005-1	2015	Novel cercaricides of PEG-N-salicylanilide derivatives that could self-spread and float on the water surface were designed and synthesized according to the particular habit of cercariae larvae of Schistosome japonicum.	Water	95-100	progestagen associated endometrial protein	Homo sapiens	22-25
33288253-10	2021	In short, our data suggests that Ddit3 promotes MC-LR-induced mice ovarian cells apoptosis and follicular atresia via ER stress activation, which provides a new insight into the relation between infertility in females and the emerging water pollutant MC-LR.	Water	235-240	DNA-damage inducible transcript 3	Mus musculus	33-38
25721096-5	2015	The photoinduced electron transfer from the excited dye that labels the oligonucleotide probe to the CoP semiconductor led to efficient fluorescence quenching, and largely enhanced the photocatalytic evolution of hydrogen from water under visible light.	Water	227-232	caspase recruitment domain family member 16	Homo sapiens	101-104
33746591-0	2021	Acid-electrolyzed functional water-induces Interleukin-1alpha release from Intracellular Storage Sites in Oral Squamous Cell Carcinoma.	Water	29-34	interleukin 1 alpha	Homo sapiens	43-61
25624099-6	2015	In contrast, activation of a second population of subfornical organ neurons, marked by expression of the vesicular GABA transporter VGAT, drastically suppresses drinking, even in water-craving thirsty animals.	Water	179-184	solute carrier family 32 member 1	Homo sapiens	132-136
33439644-2	2021	Herein we show a crucial role of water, which enables a highly enantioselective glyoxalase I-mimic catalytic isomerization of hemithioacetals which proceeds via enantioselective protonation of an ene-diol intermediate.	Water	33-38	glyoxalase I	Homo sapiens	80-92
25752532-0	2015	Water protection in the Baltic Sea and the Chesapeake Bay: institutions, policies and efficiency.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	31-34
33369428-0	2021	Structural and Dynamical Impact of Water Molecules at Substrate- or Product-Binding Sites in Human GMPR Enzyme: A Study by Molecular Dynamics Simulations.	Water	35-40	guanosine monophosphate reductase	Homo sapiens	99-103
25914628-5	2015	We found that the brain water content and Evans blue extravasation at 48 h post-MCAO were reduced by a TRPV4 antagonist HC-067047.	Water	24-29	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	103-108
33526683-1	2021	Knowledge of the temperature dependence of the isobaric specific heat (Cp) upon deep supercooling can give insights regarding the anomalous properties of water.	Water	154-159	ceruloplasmin	Homo sapiens	71-73
25523640-10	2015	The mRNA and protein expression levels of PAR-1, MMP-9 and AQP4 started to increase at 24 h and reached a maximal level at 48 h. Focal mild hypothermia tended to significantly reduce brain water content, BBB disruption and PAR-1, MMP-9 and AQP expression at 24 and 48 h. The present data suggest that focal mild hypothermia is an effective treatment for edema formation through moderation of the mRNA and protein expression of PAR-1, MMP-9 and AQP4.	Water	189-194	aquaporin 4	Rattus norvegicus	59-63
24939700-3	2015	Exposure of larvae to water enriched with NaCl (1 mM NaCl) caused a pronounced reduction in Na(+) uptake which was prevented by pharmacological inhibition of cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), two key enzymes involved in the endogenous synthesis of H2S.	Water	22-27	cystathionase (cystathionine gamma-lyase)	Danio rerio	195-220
24939700-3	2015	Exposure of larvae to water enriched with NaCl (1 mM NaCl) caused a pronounced reduction in Na(+) uptake which was prevented by pharmacological inhibition of cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), two key enzymes involved in the endogenous synthesis of H2S.	Water	22-27	cystathionase (cystathionine gamma-lyase)	Danio rerio	222-225
33526683-8	2021	From the Cp measurement, we estimated the excess entropy and self-diffusion coefficient of water and these properties decrease rapidly below 235 K.	Water	91-96	ceruloplasmin	Homo sapiens	9-11
33477026-8	2021	The limits of detection of the proposed method in detecting triazine herbicides in spiked water samples ranged from 0.014 to 0.045 ng mL-1.	Water	90-95	L1 cell adhesion molecule	Mus musculus	134-138
25608967-2	2015	GSK3beta has been shown to play a role in the ability of kidneys to concentrate urine by regulating vasopressin-mediated water permeability of collecting ducts, whereas the role of GSK3alpha has yet to be discerned.	Water	121-126	glycogen synthase kinase 3 beta	Mus musculus	0-8
33186477-6	2021	Molecular dynamics simulations revealed that attracting water molecules by charged surface substitutions is the main driver for increasing the DOX resistance of BSLA M4.	Water	56-61	biofilm-surface layer protein BslA	Bacillus subtilis	161-165
33481593-0	2021	Step-Wise Hydration of Magnesium by Four Water Molecules Precedes Phosphate Release in a Myosin Motor.	Water	41-46	myosin heavy chain 14	Homo sapiens	89-95
25733255-0	2015	Supramolecular protein assembly supports immobilization of a cytochrome P450 monooxygenase system as water-insoluble gel.	Water	101-106	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	61-90
33068139-7	2021	A 15-week treatment of both wild-type (WT) and ALDH2*2/*2 mice with 20% ethanol in the drinking water resulted in a significantly lower mineral content (p < 0.05) in the bones.	Water	96-101	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	47-52
25520007-1	2015	Aquaporin-2 (AQP2) mediates arginine vasopressin (AVP)-induced water reabsorption in the kidney collecting duct.	Water	63-68	aquaporin 2	Mus musculus	0-11
25520007-1	2015	Aquaporin-2 (AQP2) mediates arginine vasopressin (AVP)-induced water reabsorption in the kidney collecting duct.	Water	63-68	aquaporin 2	Mus musculus	13-17
33526831-2	2021	Due to abundant surface functional groups, accessible active adsorption sites, high surface area (572 m2 g-1), large pore volume (0.98 cm3 g-1), and unique fibrous structure, mesoporous MF-KCC-1 was used as a potential adsorbent for the uptake of acid fuchsine (AF) and acid orange II (AO) from water.	Water	295-300	solute carrier family 12 member 4	Homo sapiens	186-194
25540100-5	2015	In the sac preparation, NaCl secretion occurred into the lumen (Na(+) &gt; Cl(-)), and GN further enhanced Cl(-) secretion (Cl(-) &gt; Na(+)), resulting in water secretion.	Water	156-161	guanylate cyclase activator 2A	Homo sapiens	87-89
32879162-8	2021	AQP2 expression in the kidney, which reflects the renal action of vasopressin, was decreased in dDAVP-infused water-loaded mice as compared with control mice that received the same dDAVP infusion but were fed pelleted chow.	Water	110-115	aquaporin 2	Mus musculus	0-4
25544390-4	2015	The present study aims to develop a novel silymarin-loaded solid lipid nanoparticle (Sm-loaded SLN) system with enhanced bioavailability and with an ability to provide excellent hepatic protection for poorly water-soluble drugs.	Water	208-213	sarcolipin	Mus musculus	95-98
25544390-6	2015	In conclusion, Sm-loaded SLN could be a useful system for the delivery of poorly water-soluble Sm, apart from providing favourable hepatic protection.	Water	81-86	sarcolipin	Mus musculus	25-28
25233224-5	2014	FINDINGS: The results extend understanding of w/c microemulsions since previous SANS studies are based only on scattering from water core droplets.	Water	127-132	USH1 protein network component sans	Homo sapiens	80-84
33439639-2	2021	Although homogeneous CO2 hydrogenation in water catalyzed by amide-based iridium catalysts provided only a negligible amount of methanol, the combination of a multinuclear catalyst and gas-solid phase reaction conditions led to the effective production of methanol from CO2.	Water	42-47	gastrin	Homo sapiens	185-188
25491832-2	2014	To adjust the particle size of MTX/LDHs, the dropping way, the volume ratio of water to PEG-400 and different hydrothermal treatment time changed accordingly, and the results indicate that the particle size can be controlled between 90 and 140 nm.	Water	79-84	metaxin 1	Homo sapiens	31-34
25545317-1	2015	DroughtGard maize was developed through constitutive expression of cold shock protein B (CSPB) from Bacillus subtilis to improve performance of maize (Zea mays) under water-limited conditions.	Water	167-172	granzyme B	Homo sapiens	89-93
33500521-0	2021	The role of tides in bottom water export from the western Ross Sea.	Water	28-33	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	63-66
26269017-27	2015	In H2O treated control group, compared to (GT)26 and (GT)36, the basal promoter activities of HO-1 gene carrying (GT)16 repeat increased (F =41.	Water	3-6	heme oxygenase 1	Homo sapiens	94-98
26584392-0	2014	Solvent Flux Method (SFM): A Case Study of Water Access to Candida antarctica Lipase B.	Water	43-48	PAN0_003d1715	Moesziomyces antarcticus	78-84
26584392-5	2014	Candida antarctica lipase B (CALB) binds to a triglyceride-water interface with its substrate entrance channel oriented toward the hydrophobic substrate interface.	Water	59-64	PAN0_003d1715	Moesziomyces antarcticus	19-25
26584392-6	2014	The lipase-triglyceride-water system served as a model system for SFM to evaluate the influx of water molecules to the active site.	Water	24-29	PAN0_003d1715	Moesziomyces antarcticus	4-10
33500521-3	2021	Salinity of the bottom water has increased in 2018 from the previous measurements in 2008-2010, consistent with the observed salinity increase in the Ross Sea.	Water	23-28	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	155-158
26584392-6	2014	The lipase-triglyceride-water system served as a model system for SFM to evaluate the influx of water molecules to the active site.	Water	96-101	PAN0_003d1715	Moesziomyces antarcticus	4-10
33500521-6	2021	We suggest that the diurnal and low frequency tides in the western Ross Sea may control the magnitude and timing of the dense water outflow.	Water	126-131	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	72-75
25643985-1	2015	Aquaporin-7 (AQP7) is expressed in adipose tissue, permeated by water and glycerol, and is involved in lipid metabolism.	Water	64-69	aquaporin 7	Mus musculus	0-11
25643985-1	2015	Aquaporin-7 (AQP7) is expressed in adipose tissue, permeated by water and glycerol, and is involved in lipid metabolism.	Water	64-69	aquaporin 7	Mus musculus	13-17
25223650-1	2014	Kinetic and DFT results for the carbonate catalysed Co(H2O)6(2+) + H2O2 Fenton-like reaction suggest a mechanism involving the formation of a cyclic transient, cyclic-(CO4)Co(II)(OOH)(H2O)2(-) that decomposes into Co(II)(H2O)(OOH)(OH)2 + CO3 (-), i.e. no OH  radicals are involved.	Water	55-59	complement C4A (Rodgers blood group)	Homo sapiens	168-171
33210665-5	2021	Such an electrode can detect Cd2+ and Pb2+ in actual water samples so this is a good candidate to act as a simple and convenient sensor for general applications.	Water	53-58	CD2 molecule	Homo sapiens	29-32
25223650-1	2014	Kinetic and DFT results for the carbonate catalysed Co(H2O)6(2+) + H2O2 Fenton-like reaction suggest a mechanism involving the formation of a cyclic transient, cyclic-(CO4)Co(II)(OOH)(H2O)2(-) that decomposes into Co(II)(H2O)(OOH)(OH)2 + CO3 (-), i.e. no OH  radicals are involved.	Water	230-235	complement C4A (Rodgers blood group)	Homo sapiens	168-171
25242637-0	2014	The effect of myoglobin crowding on the dynamics of water: an infrared study.	Water	52-57	myoglobin	Homo sapiens	14-23
25615018-6	2015	The concentration of residual chloride ions trapped within bovine insulin fibrils grown in 0.1 M NaCl, at pD 1.9, and rinsed extensively with water afterward is less than 1 anion per 16 insulin monomers (as estimated using ion chromatography) implying absence of defined solvent-sequestered nesting sites for chloride counterions.	Water	142-147	insulin	Bos taurus	66-73
25615018-6	2015	The concentration of residual chloride ions trapped within bovine insulin fibrils grown in 0.1 M NaCl, at pD 1.9, and rinsed extensively with water afterward is less than 1 anion per 16 insulin monomers (as estimated using ion chromatography) implying absence of defined solvent-sequestered nesting sites for chloride counterions.	Water	142-147	insulin	Bos taurus	186-193
33393951-7	2021	KGM promoted the growth of Bifidobacterium animalis F1-7 in vitro, and a mixture of KGM and B. animalis F1-7 effectively promoted defaecation in mice, increased the faecal water content, shortened the defaecation time and improved the gastrointestinal transit rate.	Water	172-177	coagulation factor V	Mus musculus	104-108
25242007-6	2014	Exposure to 2.0 g/L lead in the water could significantly inhibit the protein and mRNA expression of SR; conversely enhance the expression of DAAO protein and mRNA in the hippocampus during the early developmental stages.	Water	32-37	serine racemase	Mus musculus	101-103
33479914-2	2021	Our aim was to introduce hexahistidine (His6) peptides into pertuzumab Fab to enable labeling with the [99mTc(CO)3(H2O)3]+ complex and study these radioimmunoconjugates for microSPECT/CT imaging of HER2-positive tumor xenografts in mice.	Water	115-118	FA complementation group B	Homo sapiens	71-74
25344048-1	2014	BACKGROUND: Aquaporin 5 (AQP5), a member of the aquaporin family of transmembrane channel proteins, is involved in water transport and cellular proliferation in various tumors.	Water	115-120	aquaporin 5	Gallus gallus	12-23
25344048-1	2014	BACKGROUND: Aquaporin 5 (AQP5), a member of the aquaporin family of transmembrane channel proteins, is involved in water transport and cellular proliferation in various tumors.	Water	115-120	aquaporin 5	Gallus gallus	25-29
25690036-7	2015	In addition, the potential role for DPPIV inhibitors in ameliorating heart disease is revised, focusing on the effects of the main DPPIV substrates on cardiac remodeling and renal handling of salt and water.	Water	201-206	dipeptidyl peptidase 4	Homo sapiens	131-136
33479914-10	2021	Fab were conjugated to 2.1 +- 0.5 His6 peptides and labeled with [99mTc(CO)3(H2O)3]+ to a radiochemical purity of 92-97 % at 0.4-0.8 MBq/mug.	Water	77-80	FA complementation group B	Homo sapiens	0-3
25238557-3	2015	Dispersed clusters of CdS nanorods conjugated with Co3 O4 nanoparticles are next shown to efficiently oxidize water and reduce methylene blue in solution.	Water	110-115	CDP-diacylglycerol synthase 1	Homo sapiens	22-25
33469027-0	2021	Jarosite formation in deep Antarctic ice provides a window into acidic, water-limited weathering on Mars.	Water	72-77	methionyl-tRNA synthetase 1	Homo sapiens	100-104
25618793-4	2015	The ability of the different aggregates of rHL isolated during the fibrillation process to be adsorbed at the air-water interface can provide important information about the hydrophobic properties of the protein, which can be related to changes in the secondary structure of rHL, resulting in cytotoxic or non-cytotoxic species.	Water	114-119	hes family bHLH transcription factor 1	Rattus norvegicus	43-46
25339736-7	2014	Diffusion tensor imaging studies indicate that uPA(-/-) mice have increased water diffusivity and decreased anisotropy associated with impaired dendritic spine recovery and decreased length of distal neurites in the peri-infarct cortex.	Water	76-81	plasminogen activator, urokinase	Mus musculus	47-50
33167274-9	2021	Electrochemical sensors for detecting water-soluble vitamins, such as vitamin B1, vitamin B2, vitamin B6, vitamin B9, vitamin B12, and vitamin C are discussed in detail.	Water	38-43	membrane spanning 4-domains A1	Homo sapiens	78-92
25119139-1	2014	An external reflection (ER) spectrometric device was developed to directly measure adsorbates at the supercritical carbon dioxide (SC-CO2)-water interface.	Water	139-144	complement C2	Homo sapiens	134-137
33444100-1	2021	The paper presents the effect of replacing starch (at 2%, 6% and 10%) with cricket powder (CP) on the water behavior studied by the 1H NMR method, as well as the texture of gluten-free bread during 6-day storage.	Water	102-107	ceruloplasmin	Homo sapiens	91-93
25127149-6	2014	After the removal of the TBDMS and MOM protective groups, followed by UV irradiation and the subsequent thermal reaction, the 1alpha,25-(OH)2-D3 analogues with a substituted phenyl ring attached at C-17 to replace the C-20 and C-21 were prepared.	Water	136-141	cytokine like 1	Homo sapiens	198-202
25764550-4	2015	The pancake ice bacterial communities were similar to the open-water communities, suggesting that the parent water determines the sea-ice bacterial community in the early stages of sea-ice formation.	Water	109-114	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	130-133
25764550-4	2015	The pancake ice bacterial communities were similar to the open-water communities, suggesting that the parent water determines the sea-ice bacterial community in the early stages of sea-ice formation.	Water	109-114	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	181-184
33444100-2	2021	It was noticed that the bread crumb containing CP has lower water transport rate than the control bread crumb, while concluding that 2% CP stabilizes water transport throughout the entire staling time range.	Water	60-65	ceruloplasmin	Homo sapiens	47-49
25694702-0	2015	In vitro antioxidant and pancreatic alpha-amylase inhibitory activity of isolated fractions from water extract of Qingzhuan tea.	Water	97-102	amylase alpha 2A	Homo sapiens	25-49
25128668-5	2014	An estimate of the binding energy between rosuvastatin and HMGCR has been made using: (a) a coulombic electrostatic interaction model, (b) the calculated desolvation and resolvation of the statin in water, and (c) the first shell transfer solvation energy as a proxy for the restructuring of the water molecules immediately adjacent to the active binding site of HMGCR prior to binding.	Water	199-204	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	59-64
33444100-2	2021	It was noticed that the bread crumb containing CP has lower water transport rate than the control bread crumb, while concluding that 2% CP stabilizes water transport throughout the entire staling time range.	Water	150-155	ceruloplasmin	Homo sapiens	136-138
25128668-5	2014	An estimate of the binding energy between rosuvastatin and HMGCR has been made using: (a) a coulombic electrostatic interaction model, (b) the calculated desolvation and resolvation of the statin in water, and (c) the first shell transfer solvation energy as a proxy for the restructuring of the water molecules immediately adjacent to the active binding site of HMGCR prior to binding.	Water	296-301	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	59-64
33444100-5	2021	It has been noted that the replacement of starch to 2% and 6% CP causes an increase in the molecular dynamics of water.	Water	113-118	ceruloplasmin	Homo sapiens	62-64
33521479-0	2021	Influence of Water on the Gas-Phase Reaction of Dimethyl Sulfide with BrO in the Marine Boundary Layer.	Water	13-18	gastrin	Homo sapiens	26-29
25112872-0	2014	Glutathionylation of the aquaporin-2 water channel: a novel post-translational modification modulated by the oxidative stress.	Water	37-42	aquaporin 2	Homo sapiens	25-36
25112872-1	2014	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and urine concentration.	Water	48-53	aquaporin 2	Homo sapiens	0-11
25112872-1	2014	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and urine concentration.	Water	48-53	aquaporin 2	Homo sapiens	13-17
25112872-1	2014	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and urine concentration.	Water	82-87	aquaporin 2	Homo sapiens	0-11
25562373-0	2015	Surface interrogation of CoP(i) water oxidation catalyst by scanning electrochemical microscopy.	Water	32-37	caspase recruitment domain family member 16	Homo sapiens	25-28
33356301-7	2021	Our results indicate that the hGH conformation remains stable both in pure water and in the presence of polymers, and these results are in good agreement with previous experimental data.	Water	75-80	gamma-glutamyl hydrolase	Homo sapiens	30-33
25494642-0	2015	Photoactive PDI-cobalt complex immobilized on reduced graphene oxide for photoelectrochemical water splitting.	Water	94-99	peptidyl arginine deiminase 1	Homo sapiens	12-15
25494642-1	2015	We report the synthesis of a perylene derivative (perylene tetracarboxylic di(propyl imidazole), abbreviated as PDI) that is coordinated with Co(II) ions to form a coordination polymer [PDI-Co(Cl)2(H2O)2]n (abbreviated as PDI-Co).	Water	198-201	peptidyl arginine deiminase 1	Homo sapiens	112-115
25494642-1	2015	We report the synthesis of a perylene derivative (perylene tetracarboxylic di(propyl imidazole), abbreviated as PDI) that is coordinated with Co(II) ions to form a coordination polymer [PDI-Co(Cl)2(H2O)2]n (abbreviated as PDI-Co).	Water	198-201	peptidyl arginine deiminase 1	Homo sapiens	186-189
25112872-1	2014	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and urine concentration.	Water	82-87	aquaporin 2	Homo sapiens	13-17
25112872-8	2014	Together, these new findings provide fundamental insight into cell biological aspects of AQP2 function and may be relevant to better understand and explain pathological states characterized by an oxidative stress and AQP2-dependent water reabsorption disturbs.	Water	232-237	aquaporin 2	Homo sapiens	89-93
25112872-8	2014	Together, these new findings provide fundamental insight into cell biological aspects of AQP2 function and may be relevant to better understand and explain pathological states characterized by an oxidative stress and AQP2-dependent water reabsorption disturbs.	Water	232-237	aquaporin 2	Homo sapiens	217-221
24700863-10	2014	Challenging the renal osmotic gradient by submitting mice to water deprivation, diuretic administration, or high-Na(+) diet increased renal Tis11b and decreased MR expression, particularly in the cortex, thus establishing a mechanistic pathway for osmotic regulation of MR expression in vivo.	Water	61-66	zinc finger protein 36, C3H type-like 1	Mus musculus	140-146
25494642-1	2015	We report the synthesis of a perylene derivative (perylene tetracarboxylic di(propyl imidazole), abbreviated as PDI) that is coordinated with Co(II) ions to form a coordination polymer [PDI-Co(Cl)2(H2O)2]n (abbreviated as PDI-Co).	Water	198-201	peptidyl arginine deiminase 1	Homo sapiens	186-189
33256564-7	2021	We find that the normalized diffusion and release of hEGF increases with free water content in injectable hydrogels: ranging from 0.176 at 41% free water in HA-Tyr to 0.2 at 53% free water in Gtn-HPA, while it is decreasing with hydrogel stiffness: 600 Pa for Gtn-HPA and 1440 Pa for HA-Tyr.	Water	78-83	epidermal growth factor	Homo sapiens	53-57
25560253-0	2015	Water extract of Cinnamomum cassia suppresses angiogenesis through inhibition of VEGF receptor 2 phosphorylation.	Water	0-5	vascular endothelial growth factor A	Rattus norvegicus	81-85
24700872-1	2014	Renal water reabsorption is controlled by arginine vasopressin (AVP), which binds to V2 receptors, resulting in protein kinase A (PKA) activation, phosphorylation of aquaporin 2 (AQP2) at serine 256, and translocation of AQP2 to the plasma membrane.	Water	6-11	aquaporin 2	Mus musculus	179-183
24700872-1	2014	Renal water reabsorption is controlled by arginine vasopressin (AVP), which binds to V2 receptors, resulting in protein kinase A (PKA) activation, phosphorylation of aquaporin 2 (AQP2) at serine 256, and translocation of AQP2 to the plasma membrane.	Water	6-11	aquaporin 2	Mus musculus	221-225
24700872-6	2014	The changes in AQP2 phosphorylation status were paralleled by increases in cell surface expression of AQP2 and osmotic water permeability in the absence of forskolin stimulation.	Water	119-124	aquaporin 2	Mus musculus	15-19
33256564-7	2021	We find that the normalized diffusion and release of hEGF increases with free water content in injectable hydrogels: ranging from 0.176 at 41% free water in HA-Tyr to 0.2 at 53% free water in Gtn-HPA, while it is decreasing with hydrogel stiffness: 600 Pa for Gtn-HPA and 1440 Pa for HA-Tyr.	Water	148-153	epidermal growth factor	Homo sapiens	53-57
33256564-7	2021	We find that the normalized diffusion and release of hEGF increases with free water content in injectable hydrogels: ranging from 0.176 at 41% free water in HA-Tyr to 0.2 at 53% free water in Gtn-HPA, while it is decreasing with hydrogel stiffness: 600 Pa for Gtn-HPA and 1440 Pa for HA-Tyr.	Water	148-153	epidermal growth factor	Homo sapiens	53-57
24967689-9	2014	An in vitro study demonstrated that AChE activity was more intense in HRW than in normal water with or without chlorpyrifos-oxon (CPO), the metabolically-activated form of CPF.	Water	89-94	acetylcholinesterase	Rattus norvegicus	36-40
24917194-0	2015	H2O 2 induces myocardial hypertrophy in H9c2 cells: a potential role of Ube3a.	Water	0-3	ubiquitin protein ligase E3A	Rattus norvegicus	72-77
33521461-0	2021	Synergetic Effect of Water, Temperature, and Pressure on Methane Adsorption in Shale Gas Reservoirs.	Water	21-26	gastrin	Homo sapiens	85-88
25850621-2	2015	In mammalian hypothalamus, Nesfatin-1 is expressed, together with the precursor Nucleobindin 2 (NUCB2), in regions controlling water-food intake, body weight, and glucose homeostasis.	Water	127-132	nucleobindin 2	Homo sapiens	27-37
32481889-1	2014	Water dispersible Gd3+,Yb3+,Er3+ and Gd3+,Yb3+,Tm3+ doped CaF2 nanoparticles (NPs) were prepared by one-pot hydrothermal synthesis using citrate ions as capping agents without the need for any post-synthesis reaction.	Water	0-5	GRDX	Homo sapiens	18-21
33521461-2	2021	Shale gas adsorption in the actual reservoir is not only affected by individual factors such as water content, temperature, and pressure but also by the synergetic effect of these factors.	Water	96-101	gastrin	Homo sapiens	6-9
25850621-2	2015	In mammalian hypothalamus, Nesfatin-1 is expressed, together with the precursor Nucleobindin 2 (NUCB2), in regions controlling water-food intake, body weight, and glucose homeostasis.	Water	127-132	nucleobindin 2	Homo sapiens	96-101
33521461-4	2021	The synergetic effect of water content, temperature, and pressure on shale gas adsorption is explored.	Water	25-30	gastrin	Homo sapiens	75-78
25229453-8	2014	By constantly assessing the acoustic environment associated with the seasonal ice movement in the Bering Sea, it is possible that ice seals could utilize aspects of the soundscape to gauge their safe distance to open water or the ice edge by orienting in the direction of higher sound levels indicative of open water, especially in the frequency range above 1 kHz.	Water	217-222	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	105-108
25229453-8	2014	By constantly assessing the acoustic environment associated with the seasonal ice movement in the Bering Sea, it is possible that ice seals could utilize aspects of the soundscape to gauge their safe distance to open water or the ice edge by orienting in the direction of higher sound levels indicative of open water, especially in the frequency range above 1 kHz.	Water	311-316	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	105-108
25620096-0	2015	Dipeptidyl-peptidase IV (DPP IV/CD26)-activated prodrugs: a successful strategy for improving water solubility and oral bioavailability.	Water	94-99	dipeptidyl peptidase 4	Homo sapiens	0-23
25620096-0	2015	Dipeptidyl-peptidase IV (DPP IV/CD26)-activated prodrugs: a successful strategy for improving water solubility and oral bioavailability.	Water	94-99	dipeptidyl peptidase 4	Homo sapiens	25-31
33376139-1	2021	FAD-dependent bacterial oleate hydratases (OhyA) catalyze the addition of water to isolated fatty acid carbon-carbon double bonds.	Water	74-79	AT695_RS03350	Staphylococcus aureus	24-41
25620096-0	2015	Dipeptidyl-peptidase IV (DPP IV/CD26)-activated prodrugs: a successful strategy for improving water solubility and oral bioavailability.	Water	94-99	dipeptidyl peptidase 4	Homo sapiens	32-36
24957549-0	2014	Synthesis of water-soluble Ag2Se QDs as a novel resonance Rayleigh scattering sensor for highly sensitive and selective ConA detection.	Water	13-18	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	27-30
33376139-1	2021	FAD-dependent bacterial oleate hydratases (OhyA) catalyze the addition of water to isolated fatty acid carbon-carbon double bonds.	Water	74-79	AT695_RS03350	Staphylococcus aureus	43-47
24997937-3	2014	The zones of the highest E1 and BPA concentrations in water were located at the mouth of the Huangpu River and the outfalls of wastewater treatment plants.	Water	54-59	small nucleolar RNA, H/ACA box 73A	Homo sapiens	25-35
33376139-8	2021	This active site water is a hydronium ion based on the analysis of its hydrogen bond network in the OhyA PEG400 FAD complex.	Water	17-22	AT695_RS03350	Staphylococcus aureus	100-104
25460850-0	2015	Aqueous-core PEG-coated PLA nanocapsules for an efficient entrapment of water soluble anticancer drugs and a smart therapeutic response.	Water	72-77	progestagen associated endometrial protein	Homo sapiens	13-16
33376139-9	2021	We conclude that OhyA accelerates acid-catalyzed alkene hydration by positioning the fatty acid double bond to attack the active site hydronium ion, followed by the addition of water to the transient carbocation intermediate.	Water	177-182	AT695_RS03350	Staphylococcus aureus	17-21
25460850-1	2015	Novel PEGylated PLA nanocapsules (PEG-AcPLA nanocapsules), loading high percentage of water soluble drugs have been formulated by using multiple emulsion technique without using conventional stabilizers.	Water	86-91	progestagen associated endometrial protein	Homo sapiens	6-9
33376139-10	2021	Structural transitions within S. aureus OhyA channel oleate to the active site, curl oleate around the substrate water, and stabilize the hydroxylated product to inactivate antimicrobial fatty acids.	Water	113-118	AT695_RS03350	Staphylococcus aureus	40-44
33443196-6	2021	The dynamics are controlled by two dimensionless numbers relating the average intensity and frequency of high-water events (HWEs) to the maximum dune height and dune formation time, which are in turn a function of the rate of sea level rise, sand availability, and stress of the plant ecosystem anchoring dune formation.	Water	110-115	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	226-229
26074997-2	2015	Upregulation of aquaporin-2 (AQP2) accounts for the water retention in CHF.	Water	52-57	aquaporin 2	Rattus norvegicus	16-27
26074997-2	2015	Upregulation of aquaporin-2 (AQP2) accounts for the water retention in CHF.	Water	52-57	aquaporin 2	Rattus norvegicus	29-33
24905690-6	2014	Generation of ROS in zebrafish brain due to As2O3 exposure was further evidenced by significant alteration of glutathione peroxidase (GPx) and catalase (CAT) activity, which converts H2O2 to water and helps in detoxication.	Water	191-196	catalase	Danio rerio	143-151
32869444-2	2021	A common feature of many degraded estuaries is elevated turbidity that reduces incident light to the seafloor, resulting from multiple factors including changes in sediment loading, sea-level rise and increased water column algal biomass.	Water	211-216	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	101-104
24916015-2	2014	SLC4A11 protein was recently identified as facilitating water flux across membranes.	Water	56-61	solute carrier family 4 member 11	Homo sapiens	0-7
24916015-7	2014	ER-retained CHED2 mutant SLC4A11 protein could be rescued to the plasma membrane, where it conferred 25%-30% of WT water flux level.	Water	115-120	solute carrier family 4 member 11	Homo sapiens	25-32
26435724-5	2015	Pretreatment with water layer of aqueous extract 40 g/kg significantly improved sexual performance, increased serum testosterone level, and decreased LH and GnRH level compared with microwave exposed model rats (all P &lt; 0.05).	Water	18-23	gonadotropin releasing hormone 1	Rattus norvegicus	157-161
26435724-7	2015	Protein expression of GnRH in the hypothalamus significantly decreased in the water layer of aqueous extract treated group (P &lt; 0.05).	Water	78-83	gonadotropin releasing hormone 1	Rattus norvegicus	22-26
33897301-11	2021	Water residence time (tau) and water-level change were associated with HydrAP ranks, demonstrating the framework"s intended ability to differentiate anthropogenic stressors that can alter lake hydrology.	Water	0-5	microtubule associated protein tau	Homo sapiens	22-25
26284532-10	2015	On the other hand, we find the opposite behaviour in both cases for CGOn/STN model electrodes, reporting for the first time a higher electrocatalytic activity of CGO nanoparticles for CO/CO2 than for H2/H2O reactions in the absence of gas diffusion limitations.	Water	203-206	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	73-76
25270793-2	2014	Besides playing a role in Cl(-)/HCO3(-) transport, it has been proposed that CFTR interacts with water membrane transport systems, particularly aquaporins, to control seminiferous tubular secretion, which is regulated by the somatic Sertoli cells (SCs).	Water	97-102	CF transmembrane conductance regulator	Rattus norvegicus	77-81
33157379-0	2021	Metformin chlorination byproducts in drinking water exhibit marked toxicities of a potential health concern.	Water	46-51	SAFB like transcription modulator	Homo sapiens	0-9
24652796-5	2014	The SAA-rich diet increased diuresis paralleled by downregulation of aquaporin-2 (AQP2) water channels.	Water	88-93	aquaporin 2	Mus musculus	69-80
24652796-5	2014	The SAA-rich diet increased diuresis paralleled by downregulation of aquaporin-2 (AQP2) water channels.	Water	88-93	aquaporin 2	Mus musculus	82-86
25631586-9	2015	By overexpressing the human AQP5 in mature adipocytes it was possible to ascertain its role as a water channel in a gain-of-function scenario.	Water	97-102	aquaporin 5	Homo sapiens	28-32
33157379-1	2021	Metformin (MET), a worldwide used drug for type 2 diabetes, has been found with the largest amount by weight among all drugs in aquatic environment, including the drinking water systems where this emerging micropollutant is inevitably transformed during chlorination process.	Water	172-177	SAFB like transcription modulator	Homo sapiens	0-9
33157379-1	2021	Metformin (MET), a worldwide used drug for type 2 diabetes, has been found with the largest amount by weight among all drugs in aquatic environment, including the drinking water systems where this emerging micropollutant is inevitably transformed during chlorination process.	Water	172-177	SAFB like transcription modulator	Homo sapiens	11-14
26453163-4	2015	However, the poor water solubility of beta-lap limits its clinical potential.	Water	18-23	LAP	Homo sapiens	43-46
24996271-2	2014	At parturition, cows were assigned to abomasal infusion of water (CTRL) or casein (CAS).	Water	59-64	CTRL	Bos taurus	66-70
33157379-2	2021	Whether MET chlorination byproducts Y (C4H6ClN5) and C (C4H6ClN3) exist in drinking water remains unknown.	Water	84-89	SAFB like transcription modulator	Homo sapiens	8-11
33157379-4	2021	Here we reveal that MET and byproduct C are present in worldwide drinking water with the highest doses detected for MET and C as 1203.5 ng/L and 9.7 ng/L respectively.	Water	74-79	SAFB like transcription modulator	Homo sapiens	20-23
25026002-0	2014	Examination of CO2-SO2 solubility in water by SAFT1.	Water	37-42	complement C2	Homo sapiens	15-22
33157379-5	2021	Under simulated chlorination conditions, we also demonstrate that both byproducts can be increasingly produced with increment of MET concentration, suggesting a hidden threat on the safety and sustainability of global water supply.	Water	218-223	SAFB like transcription modulator	Homo sapiens	129-132
34043188-2	2021	The synaptic protein alpha-syn is water-soluble under normal physiological conditions, but in these patients" brains, we see accumulation of insoluble amyloid-like alpha-syn fibrils with prion-like properties.	Water	34-39	synuclein alpha	Homo sapiens	21-30
24912027-3	2014	Aquaporin 4 (AQP4), a glial water channel protein expressed mainly in the nervous system, is considered a specific marker of vascular permeability and thought to play an important role in brain edema (conditions).	Water	28-33	aquaporin 4	Rattus norvegicus	0-11
25600969-2	2015	Small-molecule inhibitors of c-Myc-Max have exhibited low potency and poor water solubility and are therefore unsuitable for in vivo application.	Water	75-80	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	29-34
24912027-3	2014	Aquaporin 4 (AQP4), a glial water channel protein expressed mainly in the nervous system, is considered a specific marker of vascular permeability and thought to play an important role in brain edema (conditions).	Water	28-33	aquaporin 4	Rattus norvegicus	13-17
33005037-0	2021	Organ protection by SGLT2 inhibitors: role of metabolic energy and water conservation.	Water	67-72	solute carrier family 5 member 2	Homo sapiens	20-25
24957728-9	2014	Further, a solution-phase, non-resonant SERS spectroscopic detection method for an inorganic contaminant of ground water, arsenite, has also been developed.	Water	115-120	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	40-44
25038684-3	2014	The muscles with a high initial pH (pHi) group (pH&gt;6.4) possessing the greatest water holding capacity and lightness, contained the highest HSP90 level, followed by intermediate (6.0-6.4) and low pHi groups (pH&lt;6.0).	Water	83-88	vasoactive intestinal peptide	Sus scrofa	36-39
33005037-3	2021	Rather, patients on SGLT2 inhibitor therapy adjust to the reduction in energy availability and conserve water.	Water	104-109	solute carrier family 5 member 2	Homo sapiens	20-25
33005037-4	2021	The metabolic adaptations that are induced by SGLT2 inhibition are similar to those observed in aestivation - an evolutionarily conserved survival strategy that enables physiological adaptation to energy and water shortage.	Water	208-213	solute carrier family 5 member 2	Homo sapiens	46-51
25143599-5	2014	Forebrain-specific deletion of the Camk2a gene resulted in severe deficits in water maze and contextual fear learning, whereas mice with deletion restricted to the cerebellum learned normally.	Water	78-83	calcium/calmodulin-dependent protein kinase II alpha	Mus musculus	35-41
33058213-1	2021	The Craig-Gordon type (C-G) leaf water isotope enrichment models assume a homogeneous distribution of enriched water across the leaf surface, despite observations that Delta18 O can become increasingly enriched from leaf base to tip.	Water	33-38	cathepsin G	Homo sapiens	4-26
24944242-2	2014	AVP-mediated insertion of sweat and salivary gland aquaporin-5 (AQP5) water channels through activation of the vasopressin type 2 receptor (V2R) remains an attractive, yet unexplored, mechanism that could result in a more concentrated sweat with resultant decreased water loss.	Water	70-75	aquaporin 5	Homo sapiens	51-62
25503313-1	2014	Peptide deformylase (PDF) is a prokaryotic enzyme that catalyzes the deformylation of nascent peptides generated during protein synthesis and water molecules play a key role in these hydrolases.	Water	142-147	peptide deformylase, mitochondrial	Homo sapiens	21-24
24944242-2	2014	AVP-mediated insertion of sweat and salivary gland aquaporin-5 (AQP5) water channels through activation of the vasopressin type 2 receptor (V2R) remains an attractive, yet unexplored, mechanism that could result in a more concentrated sweat with resultant decreased water loss.	Water	70-75	aquaporin 5	Homo sapiens	64-68
24752488-3	2014	Aquaporin 4 (AQP4), expressed mainly in the brain, is an important aquaporin to control the flux of water.	Water	100-105	aquaporin 4	Rattus norvegicus	0-11
33058213-1	2021	The Craig-Gordon type (C-G) leaf water isotope enrichment models assume a homogeneous distribution of enriched water across the leaf surface, despite observations that Delta18 O can become increasingly enriched from leaf base to tip.	Water	111-116	cathepsin G	Homo sapiens	4-26
24752488-3	2014	Aquaporin 4 (AQP4), expressed mainly in the brain, is an important aquaporin to control the flux of water.	Water	100-105	aquaporin 4	Rattus norvegicus	13-17
33645130-2	2021	AP was prepared by the strategy of water extraction and alcohol precipitation, the content was determined, and its monosaccharide composition was analyzed.	Water	35-40	LIM homeobox protein 2	Mus musculus	0-2
25473361-14	2014	In addition, hot water extract of A. arguta stem exhibited appreciable inhibitory activity against alpha-glucosidase enzyme with IC50 of 1.71 mg/ml.	Water	17-22	sucrase isomaltase (alpha-glucosidase)	Mus musculus	99-116
25022880-7	2014	We confirmed this hypothesis using a mutated PPARalpha LBD in our transactivation assay to disrupt the water cluster and to validate the proposed interaction.	Water	103-108	peroxisome proliferator activated receptor alpha	Homo sapiens	45-54
25026099-4	2014	The highly mobile and immobile domains of DAGK and their water accessibilities are identified site-specifically by scalar- and dipolar-coupling based MAS ssNMR experiments, respectively.	Water	57-62	diacylglycerol kinase alpha	Homo sapiens	42-46
33353070-3	2020	In this work, atomistic molecular dynamics simulations in an explicit membrane/water environment were performed to explore the effects of substrate and inhibitor binding on the conformational dynamics of P-gp.	Water	79-84	phosphoglycolate phosphatase	Homo sapiens	204-208
24696282-1	2014	Water corrosivity in Gdansk Bay, Poland, the southern part of the Baltic Sea, was investigated.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	73-76
25195029-7	2014	The GAC-treated water gave an 8% decline in hydraulic conductivity over the 16 cm length of columns, which was significantly different from the other three source waters, which had mean declines of 26-29%.	Water	16-21	glutaminase	Homo sapiens	4-7
25195029-8	2014	Within the first 3 cm of column length, where most clogging occurred in each column, the mean hydraulic conductivity declined by 10% for GAC-treated water compared with 40-50% for the other source waters.	Water	149-154	glutaminase	Homo sapiens	137-140
33390609-0	2020	Water on Mars: Insights from apatite in regolith breccia Northwest Africa 7034.	Water	0-5	methionyl-tRNA synthetase 1	Homo sapiens	9-13
25195029-13	2014	Due to the low reduction in hydraulic conductivity, GAC-treated water quality was used to set pre-treatment targets for ASR injection of turbidity &lt;0.6 NTU, membrane filtration index (MFI) &lt; 2 s/L(2), biodegradable dissolved organic carbon (BDOC) &lt; 0.2 mg/L, total nitrogen &lt; 0.3 mg/L and residual chlorine &gt; 0.2 mg/L.	Water	64-69	glutaminase	Homo sapiens	52-55
24849698-4	2014	The order parameter capitalizes the signature of hydrate structure, i.e., polyhedral cages, and is capable of efficiently distinguishing hydrate from ice and liquid water while allowing the formation of different hydrate phases, i.e., sI, sII, and amorphous.	Water	165-170	transcription elongation factor A1	Homo sapiens	239-242
24784577-0	2014	Integrin-linked kinase regulates tubular aquaporin-2 content and intracellular location: a link between the extracellular matrix and water reabsorption.	Water	133-138	integrin linked kinase	Mus musculus	0-22
24784577-0	2014	Integrin-linked kinase regulates tubular aquaporin-2 content and intracellular location: a link between the extracellular matrix and water reabsorption.	Water	133-138	aquaporin 2	Mus musculus	41-52
24784577-10	2014	Specific ILK siRNAs and collagen I (Col) decrease ILK and AQP2 levels and AQP2 presence on the membrane of tubular mIMCD3 cells, which impairs the capacity of the cells to transport water under hypotonic stress.	Water	182-187	integrin linked kinase	Mus musculus	9-12
24907734-4	2014	For the resultant micelles, it was found to encapsulate poorly water-soluble anticancer drug (methotrexate, MTX) with the loading efficiency of 45.2%.	Water	63-68	metaxin 1	Homo sapiens	108-111
33226205-2	2020	However, human skin in nature has a hydrophobic surface and yet absorbs water throughout hydrophilic amino acid sequences in filaggrin, one of the abundant proteins in our outermost skin layer.	Water	72-77	filaggrin	Homo sapiens	125-134
24705861-5	2014	Also, significantly increased by the binge alcohol treatments was aquaporin-4 (AQP4), a water channel enriched in astrocytes that, when augmented, may trigger brain (esp.	Water	88-93	aquaporin 4	Rattus norvegicus	66-77
33293369-3	2021	ZMPSTE24 has a novel structure, with seven transmembrane spans that form a large water-filled membrane chamber whose catalytic site faces the chamber interior.	Water	81-86	zinc metallopeptidase STE24	Homo sapiens	0-8
24705861-5	2014	Also, significantly increased by the binge alcohol treatments was aquaporin-4 (AQP4), a water channel enriched in astrocytes that, when augmented, may trigger brain (esp.	Water	88-93	aquaporin 4	Rattus norvegicus	79-83
26185491-5	2014	The resulting 2,2-diaryl-1,3-dithianes were converted into diaryl ketones by either molecular iodine, N-bromo succinimide (NBS) or Selectfluor in the presence of water.	Water	162-167	nibrin	Homo sapiens	123-126
25266857-1	2014	The aggregates of perylenediimide based chemosensor (PDI 1) undergo de-aggregation induced fluorescence quenching selectively with ClO4(-) ions both in the solution and in the solid phase and can detect ClO4(-) ions in drinking water and fireworks.	Water	228-233	peptidyl arginine deiminase 1	Homo sapiens	53-58
32865870-0	2020	Interaction of alpha-Synuclein with Phospholipids and the Associated Restructuring of Interfacial Lipid Water: An Interface-Selective Vibrational Spectroscopic Study.	Water	104-109	synuclein alpha	Homo sapiens	15-30
25493516-9	2014	Whereas polystyrene and plastic water phantoms are water-equivalent for diamond, plastic scintillator, Li2B4O7 and LiF detectors, but show distance-dependent kphan(r) values for Al2O3 detector.	Water	32-37	LIF interleukin 6 family cytokine	Homo sapiens	115-118
25493516-12	2014	For 192Ir source, solid water, virtual water, RW3, and WE210 phantoms are water-equivalent for diamond, plastic scintillator, Li2B4O7 and LiF detectors, but show distance-dependent kphan(r) values for Al2O3 detector.	Water	39-44	LIF interleukin 6 family cytokine	Homo sapiens	138-141
25509307-8	2014	Such result indicated that Salvia Miltiorrhiza can reduce trauma blood stasis rat content of urine AQP2 and down-regulated AQP2 expression in kidney tissue, so as to reduce the reabsorption of water by renal tubular and increase urine output.	Water	193-198	aquaporin 2	Rattus norvegicus	99-103
25509307-8	2014	Such result indicated that Salvia Miltiorrhiza can reduce trauma blood stasis rat content of urine AQP2 and down-regulated AQP2 expression in kidney tissue, so as to reduce the reabsorption of water by renal tubular and increase urine output.	Water	193-198	aquaporin 2	Rattus norvegicus	123-127
25493516-12	2014	For 192Ir source, solid water, virtual water, RW3, and WE210 phantoms are water-equivalent for diamond, plastic scintillator, Li2B4O7 and LiF detectors, but show distance-dependent kphan(r) values for Al2O3 detector.	Water	39-44	LIF interleukin 6 family cytokine	Homo sapiens	138-141
32865870-1	2020	Interaction of a-Synuclein (aS) with biological lipid is crucial for the onset of its fibrillation at the cell membrane-water interface.	Water	120-125	synuclein alpha	Homo sapiens	15-26
25242637-3	2014	The results evidence that the vibrational properties of water remain the same in these myoglobin solutions (anharmonicity, vibrational relaxation lifetime...) and in neat water.	Water	56-61	myoglobin	Homo sapiens	87-96
25028129-3	2014	We find linear relationships between these parameters for the deep water (&gt;200 m) of the Japan Sea, suggesting that fluorescent DOM is produced in situ in the Japan Sea.	Water	67-72	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	98-101
25242637-4	2014	However, the collective properties of the water molecules are significantly affected by the presence of the protein: the orientational time increases, the solid-liquid transition is affected in the most concentrated solution and the dynamical transition of the protein is observed, from the point of view of water, even in the least concentrated solution, proving that the water and myoglobin dynamics are coupled.	Water	42-47	myoglobin	Homo sapiens	383-392
25028129-3	2014	We find linear relationships between these parameters for the deep water (&gt;200 m) of the Japan Sea, suggesting that fluorescent DOM is produced in situ in the Japan Sea.	Water	67-72	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	168-171
32743964-2	2020	The resultant mixed-metal Ti/Zr porphyrinic MOF demonstrates a much improved efficiency for gas phase CO 2 photoreduction into CH 4 and CO under visible light irradiation using water vapor compared to the parent Zr-MOF.	Water	177-182	gastrin	Homo sapiens	92-95
25028129-5	2014	We conclude that the repeated renewal of the deep water contributes to the accumulation of fluorescent DOM in the interior of the Japan Sea.	Water	50-55	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	136-139
33206736-1	2020	All atom molecular dynamic modeling was applied in order to determine water molecule and electrolyte ion concentration profiles around and inside the myoglobin molecule at various pH values.	Water	70-75	myoglobin	Homo sapiens	150-159
24756639-4	2014	In adult zebrafish, inhibition of both CBS and CSE with aminooxyacetate (AOA) and propargyl glycine (PPG) blunted or abolished the hypoxic hyperventilation, and the addition of Na2S to the water partially rescued the effects of inhibiting endogenous H2S production.	Water	189-194	cystathionase (cystathionine gamma-lyase)	Danio rerio	47-50
25466463-4	2014	Chitosan was found to affect strongly the surface activity of HPL that forms a Gibbs monolayer at the air/water interface, but did not inhibit the enzymatic action of HPL toward the DDG monolayer.	Water	106-111	galectin 1	Homo sapiens	62-65
25459766-6	2014	The membrane interactions for EMAPII exhibit typical features of a water-soluble protein, with a high energetic barrier to enter or cross the membrane.	Water	67-72	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	30-36
24891387-3	2014	Here, we review recent developments in understanding of the processes that control the changing flux of water through the main export route from the Weddell Sea into the Scotia Sea, and the transformations of the waters within the Scotia Sea and environs.	Water	104-109	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	157-160
33273526-0	2020	CCDC66 frameshift variant associated with a new form of early-onset progressive retinal atrophy in Portuguese Water Dogs.	Water	110-115	coiled-coil domain containing 66	Canis lupus familiaris	0-6
24589083-2	2014	We investigated OGG1 expression changes in fetal membranes from spontaneous preterm birth (PTB) and preterm premature rupture of the membranes (pPROM) and its changes in vitro in normal fetal membranes exposed to OS inducer water-soluble cigarette smoke extract (CSE).	Water	224-229	8-oxoguanine DNA glycosylase	Homo sapiens	16-20
24717674-2	2014	When the frogs were in water, AQP-xt5a mRNA was expressed in the skin and urinary bladder.	Water	23-28	aquaporin 5	Xenopus tropicalis	30-38
33343937-1	2020	The final dilution of urine is regulated via aquaporin-2 water channels in the distal part of the nephron.	Water	57-62	aquaporin 2	Homo sapiens	45-56
24717674-11	2014	The results suggest that AQP-xt5a might be involved in water reabsorption from the urinary bladder during dehydration, whereas AQP-xt5b might play a role in water secretion from the small granular gland.	Water	55-60	aquaporin 5	Xenopus tropicalis	25-33
24960367-6	2014	RESULTS: R1p contrast acquired with appropriate spin-lock sequences can isolate the contribution of exchanging protons in 2DG in vivo and appears to have better sensitivity and more specificity to 2DG-water exchange effects than CEST.	Water	201-206	ribonuclease A family member 3	Rattus norvegicus	9-12
33354281-8	2020	Fluid restriction and water hydration mildly increased urine osmolality and induced a 15% fall in CrCl while increased the markers of tubular damage by NAG and KIM-1.	Water	22-27	hepatitis A virus cellular receptor 1	Rattus norvegicus	160-165
32684089-6	2020	Morris water maze test was performed to evaluate cognitive function, and we found that the down-regulation of ROCK2 reduced the escape latency and increased the passing times and percentage of time spent in the target quadrant of rats.	Water	7-12	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	110-115
25008241-2	2014	Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins that allow the movement of water, but also of small solutes, such as glycerol, across cell membranes.	Water	110-115	aquaporin 3 (Gill blood group)	Homo sapiens	19-23
25190311-1	2014	DFT and MP2 calculations are performed to obtain optimized ground state geometries and binding energies of the cage and the prism conformers of water W6 clusters and Bz-W6 clusters using the aug-cc-pVDZ basis set.	Water	144-149	tryptase pseudogene 1	Homo sapiens	8-11
24816982-11	2014	The localization of NDRG2 overlaps only partially with that of aquaporin 4, the membrane-bound water channel that is concentrated in the astrocytic endfeet.	Water	95-100	NDRG family member 2	Homo sapiens	20-25
24777977-6	2014	Inhibition of protein kinase C, but not extracellular signal-regulated kinases, protein kinase A, or vasopressin V1A and V2 receptors, corrected the elevated water intake of sRA mice.	Water	158-163	steroid receptor RNA activator 1	Mus musculus	174-177
33079458-9	2020	Notably, Shrm4 also increased pole climbing speed, reduced foot faults, and increased escape latency in the Morris water maze test, while reducing neuron autophagy through an interaction with GABAB receptors.	Water	115-120	shroom family member 4	Mus musculus	9-14
24923510-2	2014	The photoconversion under UV irradiation of both pesticides into strongly fluorescent photoproducts was performed in several media (methanol, ethanol, acetonitrile, pH4 aqueous solution and pH4 water-methanol (30:70, v/v) mixture).	Water	194-199	prolyl 4-hydroxylase, transmembrane	Homo sapiens	190-193
25211263-1	2014	Bicyclic dibrominated C15 medium-ring ether hexahydrolaureoxanyne was produced directly from an acyclic model C15-epoxide when treated with NBS with water as the solvent.	Water	149-154	nibrin	Homo sapiens	140-143
32780264-2	2020	Fluorescent intensity of the CdS quantum dots was enhanced about 5 folds by simple solvent exchange from water to 90 vol% PEG200.	Water	105-110	CDP-diacylglycerol synthase 1	Homo sapiens	29-32
25362296-0	2014	Low energy isomers of (H2O)25 from a hierarchical method based on Monte Carlo temperature basin paving and molecular tailoring approaches benchmarked by MP2 calculations.	Water	23-26	tryptase pseudogene 1	Homo sapiens	153-156
25560240-0	2014	Effect of a natural mineral-rich water on catechol-O-methyltransferase function.	Water	33-38	catechol-O-methyltransferase	Rattus norvegicus	42-70
33120076-12	2020	CONCLUSIONS: Increased kurtosis in gray matter structures in cognitively normal PD reflects increased hindrance to water diffusion caused probably by alpha-synuclein-related microstructural changes.	Water	115-120	synuclein alpha	Homo sapiens	150-165
24970686-2	2014	The aim of this study was to test the hypothesis that abnormal activity of the aquaporin-2 water channels (AQP2), the sodium-potassium-2chloride transporter (NKCC2) and/or the epithelial sodium channels (ENaC) contribute to this phenomenon.	Water	91-96	aquaporin 2	Homo sapiens	107-111
24861208-5	2014	The catalytic activities of [Sc(OTf)3] and [In(OTf)3] for Lewis acid-catalyzed reactions with carbonyl compounds in water were far superior to the other metal triflates, which indicates that the high stability of metal triflate-carbonyl compound complexes cause high catalytic performance for these reactions.	Water	116-121	POU class 5 homeobox 1	Homo sapiens	32-37
24897129-4	2014	In the first excited state, the intermolecular H-Bs between water molecule and DCO in DCOH2 are cooperatively and generally strengthened and thus induced the weak fluorescence emission of DCO, while the cooperative H-Bs between water molecule and DCOT in DCOTH4 are overall weakened and thus responsible for the enhanced fluorescence emission of DCOT.	Water	228-233	pterin-4 alpha-carbinolamine dehydratase 2	Homo sapiens	86-91
24861208-5	2014	The catalytic activities of [Sc(OTf)3] and [In(OTf)3] for Lewis acid-catalyzed reactions with carbonyl compounds in water were far superior to the other metal triflates, which indicates that the high stability of metal triflate-carbonyl compound complexes cause high catalytic performance for these reactions.	Water	116-121	POU class 5 homeobox 1	Homo sapiens	47-52
33255239-17	2020	ADM-attenuated water reabsorption may be related to decreased trafficking of AQP2 to the plasma membrane.	Water	15-20	aquaporin 2	Rattus norvegicus	77-81
24861208-6	2014	Density functional theory (DFT) calculation suggests that low LUMO levels of [Sc(OTf)3] and [In(OTf)3] would be responsible for the formation of stable coordination intermediate with nucleophilic reactant in water.	Water	208-213	POU class 5 homeobox 1	Homo sapiens	81-86
24861208-6	2014	Density functional theory (DFT) calculation suggests that low LUMO levels of [Sc(OTf)3] and [In(OTf)3] would be responsible for the formation of stable coordination intermediate with nucleophilic reactant in water.	Water	208-213	POU class 5 homeobox 1	Homo sapiens	96-101
33324834-2	2020	The gas and water generated by this decomposition increase the pressure of the gas in the decomposition zone, resulting in excessive pore pressure.	Water	12-17	gastrin	Homo sapiens	79-82
24847944-7	2014	The immuno-LC-SRM assay has a limit of detection of 2 x 10(4) CFU/mL in milk or tap water, which compares well with those of state-of-the-art immunoassays.	Water	84-89	repA translation protein	Yersinia pestis	80-83
24832237-2	2014	The anti-methotrexate Fab fragment features a remarkably rigid tunnel-like binding site that extends into a water channel serving as a specialized route to move solvent out and into the site upon ligand binding and dissociation.	Water	108-113	FA complementation group B	Homo sapiens	22-25
33153260-0	2020	Breakdown of the Stokes-Einstein Relation in Supercooled Water/Methanol Binary Mixtures: Explanation Using the Translational Jump-Diffusion Approach.	Water	57-62	squalene epoxidase	Homo sapiens	17-32
24832217-1	2014	The efficient formation of HCN/HNC from formamide (FM) combining the advantages of water-assistance, self-catalyzed reactions, and the mineral surfaces was investigated.	Water	83-88	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	27-30
24508605-3	2014	Molecular dynamic simulations (100 ns) were performed on the 3-D molecular model of beta3-AR and complexes of beta3-AR with potential agonists embedded in 2-dipalmitoyl-sn-phosphocholine (DPPC) bilayer-water system using OPLS (Optimized Potentials for Liquid Simulations) force field to gain structural insight into beta3-AR.	Water	202-207	adrenoceptor beta 3	Homo sapiens	110-118
24508605-3	2014	Molecular dynamic simulations (100 ns) were performed on the 3-D molecular model of beta3-AR and complexes of beta3-AR with potential agonists embedded in 2-dipalmitoyl-sn-phosphocholine (DPPC) bilayer-water system using OPLS (Optimized Potentials for Liquid Simulations) force field to gain structural insight into beta3-AR.	Water	202-207	adrenoceptor beta 3	Homo sapiens	110-118
33153260-1	2020	A recent experiment has directly checked the validity of the Stokes-Einstein (SE) relation for pure water, pure methanol, and their binary mixtures of three different compositions at different temperatures.	Water	100-105	squalene epoxidase	Homo sapiens	61-76
33153260-1	2020	A recent experiment has directly checked the validity of the Stokes-Einstein (SE) relation for pure water, pure methanol, and their binary mixtures of three different compositions at different temperatures.	Water	100-105	squalene epoxidase	Homo sapiens	78-80
33153260-4	2020	Violations of the SE relation in pure supercooled water at different temperatures and pressures have been previously explained using the translational jump-diffusion (TJD) approach, which provides a fundamental molecular basis, by directly connecting the SE breakdown with jump-diffusion of the molecules.	Water	50-55	squalene epoxidase	Homo sapiens	18-20
33153260-4	2020	Violations of the SE relation in pure supercooled water at different temperatures and pressures have been previously explained using the translational jump-diffusion (TJD) approach, which provides a fundamental molecular basis, by directly connecting the SE breakdown with jump-diffusion of the molecules.	Water	50-55	squalene epoxidase	Homo sapiens	255-257
24644297-2	2014	The passive permeability across the blood-brain barrier (BBB), PS1, was predicted by two methods using log(D/molecular weight(0.5)) for PS1(1) or the partition coefficient in octanol/water at pH 7.4 (LogD), topologic van der Waals polar surface area, and van der Waals surface area of the basic atoms for PS1(2).	Water	183-188	presenilin 1	Rattus norvegicus	63-66
33153260-5	2020	We have used the same TJD approach for explaining the SE breakdown for the methanol/water binary mixtures of compositions studied in the experiment over a wide range of temperatures between 220 K and 300 K. We have understood that the jump-diffusion is the key responsible factor for the SE breakdown.	Water	84-89	squalene epoxidase	Homo sapiens	54-56
33153260-5	2020	We have used the same TJD approach for explaining the SE breakdown for the methanol/water binary mixtures of compositions studied in the experiment over a wide range of temperatures between 220 K and 300 K. We have understood that the jump-diffusion is the key responsible factor for the SE breakdown.	Water	84-89	squalene epoxidase	Homo sapiens	288-290
24636993-0	2014	GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts.	Water	21-26	aquaporin 2	Mus musculus	59-70
33153260-7	2020	This study, therefore, provides molecular insight into the SE breakdown for the supercooled water/methanol binary mixture, as found in the experiment.	Water	92-97	squalene epoxidase	Homo sapiens	59-61
24636993-3	2014	Upon purification of the GFP-positive cells, we found that collecting duct (CD)-specific markers, including aquaporin 2 (Aqp2), an important channel for water reabsorption from urine, were abundantly expressed.	Water	153-158	aquaporin 2	Mus musculus	108-119
33156603-6	2020	Adequate surface functionalization using asymmetric double-hydrophilic block copolymers, constituted of a metal-binding block and a neutral water-soluble block, provides stabilized YAG:Nd3+ nanocrystals with long-term colloidal stability in aqueous suspensions.	Water	140-145	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	185-188
24636993-3	2014	Upon purification of the GFP-positive cells, we found that collecting duct (CD)-specific markers, including aquaporin 2 (Aqp2), an important channel for water reabsorption from urine, were abundantly expressed.	Water	153-158	aquaporin 2	Mus musculus	121-125
32526652-2	2020	Hop water extract (HWE) and hop ethanol extracts (HEEs) were prepared by extracting hop pellets with hot water at 90  C and ethanol solutions (55%, 75%, and 95%), respectively.	Water	4-9	HOP homeobox	Homo sapiens	0-3
24802888-5	2014	The simulation results showed that the immobilized cCP1 (via the N-terminus) tends to bend and gradually lie down onto the SAM surface, due to the large structural fluctuation of the C-terminus induced by unfavorable interactions between the hydrophobic C-terminal residues and water.	Water	278-283	coiled-coil domain containing 115	Homo sapiens	51-55
33204889-2	2020	It focuses on the impacts of changes in mixed water quality on the Dead Sea ecosystem and the current industrial activities.	Water	46-51	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	72-75
24460811-4	2014	RESULTS: The addition of chest compressions to mask ventilation led to a significant reduction in inflation rate, from 63.9 to 32.9 breaths per minute (p &lt; 0.0001), mean airway pressure reduced from 7.6 to 4.9 cm H2 O (p &lt; 0.001), minute ventilation reduced from 770 to 451 mL/kg/min (p &lt; 0.0001), and there was a significant increase in paired mask leak of 6.8% (p &lt; 0.0001).	Water	216-220	ankyrin repeat and KH domain containing 1	Homo sapiens	47-51
33204889-4	2020	The Red Sea - Dead Sea water mixing was controlled and done based on the expected mixing ratios between Red Sea and Dead Sea waters to mimic the potential actual situation associated with Red Sea - Dead Sea project conduit.	Water	23-28	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	19-22
33204889-4	2020	The Red Sea - Dead Sea water mixing was controlled and done based on the expected mixing ratios between Red Sea and Dead Sea waters to mimic the potential actual situation associated with Red Sea - Dead Sea project conduit.	Water	23-28	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	19-22
25353799-3	2014	Instead, these behaviors are shown to be attributable to the measurement error caused by interfacial rheology due to adsorption of bovine serum albumin to the air and water interface.	Water	167-172	albumin	Bos taurus	138-151
33204889-4	2020	The Red Sea - Dead Sea water mixing was controlled and done based on the expected mixing ratios between Red Sea and Dead Sea waters to mimic the potential actual situation associated with Red Sea - Dead Sea project conduit.	Water	23-28	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	19-22
33204889-4	2020	The Red Sea - Dead Sea water mixing was controlled and done based on the expected mixing ratios between Red Sea and Dead Sea waters to mimic the potential actual situation associated with Red Sea - Dead Sea project conduit.	Water	23-28	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	19-22
24717022-6	2014	Compared to similar systems in which monomeric porphyrins are simply physisorbed, MWNT-CoP hybrids showed a higher ORR activity associated with a number of exchanged electrons close to four, corresponding to the complete reduction of oxygen into water.	Water	246-251	caspase recruitment domain family member 16	Homo sapiens	87-90
33204889-4	2020	The Red Sea - Dead Sea water mixing was controlled and done based on the expected mixing ratios between Red Sea and Dead Sea waters to mimic the potential actual situation associated with Red Sea - Dead Sea project conduit.	Water	23-28	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	19-22
33204889-6	2020	The properties variations depend on the rate of diluting the Dead Sea water by Red Sea water and rejected brine.	Water	70-75	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	66-69
33204889-6	2020	The properties variations depend on the rate of diluting the Dead Sea water by Red Sea water and rejected brine.	Water	70-75	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	83-86
24684587-0	2014	Evaporative assembly of MEH-PPV rings using mixed solvents at the air/water interface.	Water	70-75	epoxide hydrolase 1	Homo sapiens	24-27
33204889-6	2020	The properties variations depend on the rate of diluting the Dead Sea water by Red Sea water and rejected brine.	Water	87-92	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	66-69
33204889-6	2020	The properties variations depend on the rate of diluting the Dead Sea water by Red Sea water and rejected brine.	Water	87-92	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	83-86
33204889-7	2020	The least altered physical properties were observed when the Red Sea concentrated brine was added to the Dead Sea water (tank 5).	Water	114-119	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	65-68
33204889-7	2020	The least altered physical properties were observed when the Red Sea concentrated brine was added to the Dead Sea water (tank 5).	Water	114-119	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	110-113
24751148-5	2014	Double immunostaining reveals that after I/R, Iba-1 immunoreactivity increased gradually 12 h after reperfusion and maintained at a such level throughout 36 h. Such increasing pattern of Iba-1 expression is consistent with the increases in Evan"s Blue (EB) extravasation, spinal water content and mechanical allodynia demonstrated by lowed withdrawal threshold to Von Frey filaments.	Water	279-284	allograft inflammatory factor 1	Rattus norvegicus	46-51
33204889-8	2020	The obtained results show that transferring Red Sea water to Dead Sea would lead to dilution of Dead Sea brine and affects significantly the investigated mixed water physical properties.	Water	52-57	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	48-51
24751148-5	2014	Double immunostaining reveals that after I/R, Iba-1 immunoreactivity increased gradually 12 h after reperfusion and maintained at a such level throughout 36 h. Such increasing pattern of Iba-1 expression is consistent with the increases in Evan"s Blue (EB) extravasation, spinal water content and mechanical allodynia demonstrated by lowed withdrawal threshold to Von Frey filaments.	Water	279-284	allograft inflammatory factor 1	Rattus norvegicus	187-192
33153423-2	2021	By sonicator and microwave of commercially available styrene with NBS in water followed by reaction with 2-aminopyridines afforded important heterocyclic scaffolds in an exceedingly one-pot procedure.	Water	73-78	nibrin	Homo sapiens	66-69
24684841-1	2014	A water soluble beta-1,3-glucan schizophyllan (SPG) can be recognized by an immunocyte receptor called dectin-1.	Water	2-7	C-type lectin domain containing 7A	Homo sapiens	103-111
33054242-1	2020	Here, we investigate the role of a dilute hydrophobic gas on the phase behavior of water confined in hydrophobic nanopores.	Water	83-88	gastrin	Homo sapiens	54-57
24709946-2	2014	In dat-1(ok157) animals, DA is not taken back up presynaptically but instead reaches extrasynpatic sites, where it activates the dopamine receptor DOP-3 on choligeneric motor neurons and causes animals to become paralyzed in water.	Water	225-230	Sodium-dependent dopamine transporter	Caenorhabditis elegans	3-8
32088966-10	2020	The water (iodine) concentrations of ChRCC and PRCC in CP and PP were not statistically different (P > 0.05).	Water	4-9	proline rich mitotic checkpoint control factor	Homo sapiens	47-51
24569668-1	2014	Single-stranded DNA (ss-DNA) oligomers (dA20, d[(C3TA2)3C3] or dT20) are able to disperse single-walled carbon nanotubes (SWNTs) in water at pH 7 through non-covalent wrapping on the nanotube surface.	Water	132-137	thioredoxin peroxidase 1	Drosophila melanogaster	63-67
24882978-10	2014	Serum levels of IL-4 and IL-5 were significantly decreased in the mineral water group but not in the distilled water group.	Water	74-79	interleukin 4	Mus musculus	16-20
24882978-10	2014	Serum levels of IL-4 and IL-5 were significantly decreased in the mineral water group but not in the distilled water group.	Water	74-79	interleukin 5	Mus musculus	25-29
23651078-0	2014	Phosphorylation of Ser-180 of rat aquaporin-4 shows marginal affect on regulation of water permeability: molecular dynamics study.	Water	85-90	aquaporin 4	Rattus norvegicus	34-45
23651078-1	2014	Water permeation through rat aquaporin-4 (rAQP4), predominantly found in mammalian brain is regulated by phosphorylation of Ser-180.	Water	0-5	aquaporin 4	Rattus norvegicus	29-40
23651078-1	2014	Water permeation through rat aquaporin-4 (rAQP4), predominantly found in mammalian brain is regulated by phosphorylation of Ser-180.	Water	0-5	aquaporin 4	Rattus norvegicus	42-47
23651078-5	2014	This results in movement of C-terminal region of rAQP4 towards the cytoplasmic mouth of water channel.	Water	88-93	aquaporin 4	Rattus norvegicus	49-54
23651078-9	2014	The simulation studies showed a continuous movement of water in a single file across pore of unphosphorylated as well as phosphorylated rAQP4.	Water	55-60	aquaporin 4	Rattus norvegicus	136-141
24482156-1	2014	In this work, we use MP2 and coupled-cluster with single, double, and perturbative triple excitations [CCSD(T)] as well as their corresponding explicitly correlated (F12) counterparts to compute the interaction energies of water icosamers.	Water	223-228	tryptase pseudogene 1	Homo sapiens	21-24
24663151-5	2014	Remarkably, this water network and Na+ ion is highly conserved between beta1AR and the adenosine A2A receptor (rmsd of 0.3 A), despite an overall rmsd of 2.4 A for all Calpha atoms and only 23% amino acid identity in the transmembrane regions.	Water	17-22	adenosine A2a receptor	Homo sapiens	87-109
24504060-0	2014	Enhanced MRI relaxivity of aquated Gd3+ ions by carboxyphenylated water-dispersed graphene nanoribbons.	Water	66-71	GRDX	Homo sapiens	35-38
24504060-1	2014	The present study demonstrates that highly water-dispersed graphene nanoribbons dispersed by carboxyphenylated substituents and conjugated to aquated Gd(3+) ions can serve as a high-performance contrast agent (CA) for applications in T1- and T2-weighted magnetic resonance imaging (MRI) with relaxivity (r1,2) values outperforming currently-available clinical CAs by up to 16 times for r1 and 21 times for r2.	Water	43-48	CD1b molecule	Homo sapiens	386-395
25061569-5	2014	Abeta-induced effects are prevented when neurons are co-incubated with trolox (the water-soluble analog of vitamin E).	Water	83-88	amyloid beta (A4) precursor protein	Mus musculus	0-5
24533785-1	2014	The reactions of ketones and aldehydes in the presence of Li(+) and in the presence or absence of PTC mediated by water were performed to produce aldol products.	Water	114-119	coiled-coil domain containing 6	Homo sapiens	98-101
23784805-3	2014	In particular, a nearly threefold increase in motional amplitudes of the backbone librations about C-Calpha or N-Calpha bonds was found on increasing the added water content up to 47 wt%D2 O.	Water	160-165	CEA cell adhesion molecule 6	Homo sapiens	111-119
25274525-3	2014	These layers host a well resolved R12 dodecameric discrete ring of water clusters built by six independent molecules located around the 2c centrosymmetric Wyckoff positions of the P21/n space group in which the compound crystallizes.	Water	67-72	H3 histone pseudogene 16	Homo sapiens	180-183
25031229-4	2014	SST-14 and cortistatin (CST-14) (1 mug/rat icv) increased water intake by 3.1- and 2.7-fold, respectively, while both peptides did not alter food intake at 1 h postinjection in the light phase.	Water	58-63	cystatin SC	Rattus norvegicus	24-30
25031229-7	2014	The sst2 antagonist S-406-028 (1 mug/rat icv) prevented the 1-h water intake induced by intracerebroventricular ODT8-SST and CST-14.	Water	64-69	cystatin SC	Rattus norvegicus	125-131
25145394-6	2014	The high sensitivity of this method was demonstrated by detection of human serum albumin and human cytochrome b5 in 10(-17) -10(-18) m water solutions.	Water	135-140	cytochrome b5 type A	Homo sapiens	99-112
24700872-1	2014	Renal water reabsorption is controlled by arginine vasopressin (AVP), which binds to V2 receptors, resulting in protein kinase A (PKA) activation, phosphorylation of aquaporin 2 (AQP2) at serine 256, and translocation of AQP2 to the plasma membrane.	Water	6-11	aquaporin 2	Mus musculus	166-177
25095973-4	2014	Renal collecting duct water absorption is mainly mediated by the water channel aquaporin 1 and 2 (AQP1 and AQP2).	Water	22-27	aquaporin-2	Capra hircus	107-111
25095973-4	2014	Renal collecting duct water absorption is mainly mediated by the water channel aquaporin 1 and 2 (AQP1 and AQP2).	Water	65-70	aquaporin-2	Capra hircus	107-111
24990857-1	2014	Guanylin (GN) inhibited water absorption and short-circuit current (Isc) in seawater eel intestine.	Water	24-29	guanylate cyclase activator 2A	Homo sapiens	0-8
25207608-8	2014	MOR and DOR also link to inhibition of submucosal secretomotor neurons, reducing active Cl(-) secretion and passive water movement into the colonic lumen.	Water	116-121	opioid receptor mu 1	Homo sapiens	0-3
26278261-0	2014	Correction to "Bulk Liquid Water at Ambient Temperature and Pressure from MP2 Theory".	Water	27-32	tryptase pseudogene 1	Homo sapiens	74-77
25184686-7	2014	It would be tempting to suggest that AQP3 and AQP1 are involved in the secretion of water into milk.	Water	84-89	aquaporin 3 (Gill blood group)	Rattus norvegicus	37-41
25184686-10	2014	AQP3 was identified primarily at the basal and lateral membranes of the secretory cells, suggesting a possible involvement in regulated uptake of water and glycerol.	Water	146-151	aquaporin 3 (Gill blood group)	Rattus norvegicus	0-4
24863057-10	2014	Although the Nogo-66 Glu26Ala free energy of transfer from water into lipid is similar to that of WT, NMR data reveal a dramatic loss of tertiary structure for the mutant in DPC micelles.	Water	59-64	reticulon 4	Homo sapiens	13-17
24905690-6	2014	Generation of ROS in zebrafish brain due to As2O3 exposure was further evidenced by significant alteration of glutathione peroxidase (GPx) and catalase (CAT) activity, which converts H2O2 to water and helps in detoxication.	Water	191-196	catalase	Danio rerio	153-156
24893328-1	2014	To clarify the mechanism of high-mobility group box (HMGB) 1-induced brain edema formation, this study focused on the effect of HMGB1 on aquaporin (AQP) 4, a water channel, in rat brain.	Water	158-163	aquaporin 4	Rattus norvegicus	148-154
25782277-0	2014	[Upward and regeneration fluxes of inorganic nitrogen and phosphorus in the deep-water areas of the Black-Sea].	Water	81-86	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	106-109
24988375-1	2014	We report on an Atomic Force Microscopy (AFM) study of AFM tip-nanobubble interactions in experiments conducted on argon surface nanobubbles on HOPG (highly oriented pyrolytic graphite) in water in tapping mode, lift mode and Force Volume (FV) mode AFM.	Water	189-194	TOR signaling pathway regulator	Homo sapiens	59-62
24780165-9	2014	Interestingly, we show that for a similar molecular weight, the unfolded alpha-synuclein forms a layer with the highest percentage of solvation not related to surface coverage but resulting from the highest water content trapped within the protein.	Water	207-212	synuclein alpha	Homo sapiens	73-88
24797098-0	2014	Poly(lactic acid) nanoparticles coated with combined WGA and water-soluble chitosan for mucosal delivery of beta-galactosidase.	Water	61-66	galactosidase, beta 1	Rattus norvegicus	108-126
25098339-3	2014	Recently, in the crystallized adenosine A2A receptor (4EIY), a sodium ion was found in a pocket, coordinated by Asp52, Ser91, and three water molecules.	Water	136-141	adenosine A2a receptor	Homo sapiens	30-52
32866627-6	2020	Pkd1RC/RC mice were treated 2% TRE in water from days 50 to 120 of age.	Water	38-43	polycystin 1, transient receptor potential channel interacting	Mus musculus	0-6
25098339-8	2014	The Gln7.42 at hH4R disrupts a water chain, connecting the Asp3.32 of the orthosteric binding site and the Asp2.50 of the allosteric binding site.	Water	31-36	histamine receptor H4	Homo sapiens	15-19
24598363-2	2014	Short-term regulation of water transport is dependent on vasopressin-induced phosphorylation of aquaporin-2 (AQP2) at Ser256.	Water	25-30	aquaporin 2	Rattus norvegicus	96-107
24598363-2	2014	Short-term regulation of water transport is dependent on vasopressin-induced phosphorylation of aquaporin-2 (AQP2) at Ser256.	Water	25-30	aquaporin 2	Rattus norvegicus	109-113
32594417-0	2020	Source apportionment of water pollutants in the upstream of Yangtze River using APCS-MLR.	Water	24-29	amyloid P component, serum	Homo sapiens	80-84
32959392-7	2020	The optimized Alg-PSS hydrogel (Alg5 -PSS0.75 -MBAA2.5 ) shows a dramatic tensile modulus change from 191.3 kPa in deionized water (DIW) to 15.1 kPa in 2.0 mol L-1 NaCl solution with a negligible volume increase ratio of only 0.6%.	Water	125-130	ALG5 dolichyl-phosphate beta-glucosyltransferase	Homo sapiens	32-36
24625878-5	2014	However, opposing expression patterns were observed for VEGF receptors (an increase and a decrease for VEGFR1 and VEGFR2, respectively) in FRUCT animals, with these patterns being strengthened by mineral-rich water ingestion.	Water	209-214	vascular endothelial growth factor A	Rattus norvegicus	56-60
25560240-5	2014	So, the aim of this work was to investigate the effect of natural mineral-rich water ingestion upon liver and adrenal glands COMT expression and activity in Wistar Han rats.	Water	79-84	catechol-O-methyltransferase	Rattus norvegicus	125-129
25560240-10	2014	In conclusion, the ability of natural mineral-rich waters to increase hepatic COMT activity may eventually explain the positive cardiovascular effects associated with the consumption of some natural mineral-rich waters.	Water	51-57	catechol-O-methyltransferase	Rattus norvegicus	78-82
25560240-10	2014	In conclusion, the ability of natural mineral-rich waters to increase hepatic COMT activity may eventually explain the positive cardiovascular effects associated with the consumption of some natural mineral-rich waters.	Water	212-218	catechol-O-methyltransferase	Rattus norvegicus	78-82
32738246-6	2020	Occurrence frequency and variability of toxin composition were investigated in conjunction to physico-chemical parameters in the surrounding sea water.	Water	145-150	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	141-144
25082856-0	2014	Arabidopsis SNAREs SYP61 and SYP121 coordinate the trafficking of plasma membrane aquaporin PIP2;7 to modulate the cell membrane water permeability.	Water	129-134	plasma membrane intrinsic protein 3	Arabidopsis thaliana	92-98
33204474-0	2020	Shell biomass material supported nano-zero valent iron to remove Pb2+ and Cd2+ in water.	Water	82-87	CD2 molecule	Homo sapiens	74-77
32975118-2	2020	The research was performed to model an evolution of spatial structure of d(A)5 d(T)5 and d(G)5 d(C)5 DNA mini-helixes all the way from vacuum to water bulk.	Water	145-150	complement C5	Homo sapiens	89-100
25074859-6	2014	Intrinsic water-use efficiency scaled negatively with carbon isotope discrimination (Delta13Cbl) and positively with the ratio between mesophyll diffusion conductance (gm) and stomatal conductance.	Water	10-15	Cbl proto-oncogene	Homo sapiens	92-95
33086639-0	2020	Removal of Cd2+ from Water by Use of Super-Macroporous Cryogels and Comparison to Commercial Adsorbents.	Water	21-26	CD2 molecule	Homo sapiens	11-14
33086639-7	2020	The cryogels were compared to commercially available adsorbents (zeolite Y and cation exchange resin) for the removal of Cd2+ from various water matrices (ultrapure water, tap water and river water) and the results showed that, under the experimental conditions used, the cryogels can be more effective adsorbents.	Water	139-144	CD2 molecule	Homo sapiens	121-124
24821805-0	2014	Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling.	Water	0-5	pickpocket 28	Drosophila melanogaster	13-18
32504902-7	2020	The analysis on the catalysis mechanism of MOR and water splitting in alkaline medium was also proposed.	Water	51-56	opioid receptor mu 1	Homo sapiens	43-46
24821805-4	2014	We found that loss of the critical water sensor, pickpocket 28 (ppk28), altered metabolic homeostasis to promote internal lipid and water stores and extended healthy lifespan.	Water	35-40	pickpocket 28	Drosophila melanogaster	49-62
24821805-4	2014	We found that loss of the critical water sensor, pickpocket 28 (ppk28), altered metabolic homeostasis to promote internal lipid and water stores and extended healthy lifespan.	Water	35-40	pickpocket 28	Drosophila melanogaster	64-69
24821805-4	2014	We found that loss of the critical water sensor, pickpocket 28 (ppk28), altered metabolic homeostasis to promote internal lipid and water stores and extended healthy lifespan.	Water	132-137	pickpocket 28	Drosophila melanogaster	49-62
24821805-4	2014	We found that loss of the critical water sensor, pickpocket 28 (ppk28), altered metabolic homeostasis to promote internal lipid and water stores and extended healthy lifespan.	Water	132-137	pickpocket 28	Drosophila melanogaster	64-69
33060687-0	2020	Submesoscale modulation of deep water formation in the Labrador Sea.	Water	32-37	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	64-67
24824101-1	2014	A novel water-stable (t1/2 ~ 6.8 days) mononuclear manganese(IV) complex of a hexacoordinating non-Schiff-base ligand (H4L) with N2O4-donor atoms has been synthesized and characterized crystallographically.	Water	8-13	H4 clustered histone 7	Homo sapiens	119-122
24726196-13	2014	Altered filaggrin expression has physiologic effects on transepidermal water loss and pH in the skin of patients with CIU, suggesting increased barrier function compared with skin from patients with AD.	Water	71-76	filaggrin	Homo sapiens	8-17
33060687-5	2020	Submesoscale circulations modify and control the Labrador Sea contribution to the global meridional overturning, with a linear relationship between time-averaged near surface vorticity and/or frontogenetic tendency along the west coast of Greenland, and volume of convected water.	Water	274-279	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	58-61
24916350-9	2014	The subcellular colocalization of Kir4.1 and AQP4 in epithelial supporting cells indicates functional coupling of potassium and water flow in the cochlea.	Water	128-133	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	34-40
24379183-5	2014	In dilated cardiomyopathy mice, ANP protected against the development of heart failure as indicated by reduced lung water, alveolar congestion, pleural effusions, etc.	Water	116-121	natriuretic peptide type A	Mus musculus	32-35
32667815-4	2020	Here, we report a biphasic liquid system, capable of generating microbubbles at low optical power/temperature by formulating PFP as a volatile, water-immiscible component in the aqueous host.	Water	144-149	perforin 1	Homo sapiens	125-128
24711750-10	2014	It was evident from the results of drinking of the arsenic contaminated water of shallow tube wells that the levels of DBH activity decreased significantly as compared to the control healthy persons.	Water	72-77	dopamine beta-hydroxylase	Homo sapiens	119-122
33162890-4	2020	Colitis was induced in CD1 mice by 4% w/v DSS in drinking water for five consecutive days followed by normal drinking water.	Water	58-63	CD1 antigen complex	Mus musculus	23-26
24338153-3	2014	Immunohistochemical techniques have confirmed the presence of aquaporin 1 (AQP1) and AQP3 water channels in rat, mouse, bovine and human mammary glands.	Water	90-95	aquaporin 3 (Gill blood group)	Rattus norvegicus	85-89
24824526-4	2014	Here, the interaction of water-soluble tetrapyridinoporphyrazinatozinc(II) with 27-nt G-rich strand (G/c-MYC), its equimolar mixture with the complementary sequence (GC/c-MYC) and related C-rich oligonucleotide (C/c-MYC) is investigated.	Water	25-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	103-108
24824526-4	2014	Here, the interaction of water-soluble tetrapyridinoporphyrazinatozinc(II) with 27-nt G-rich strand (G/c-MYC), its equimolar mixture with the complementary sequence (GC/c-MYC) and related C-rich oligonucleotide (C/c-MYC) is investigated.	Water	25-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	169-174
24824526-4	2014	Here, the interaction of water-soluble tetrapyridinoporphyrazinatozinc(II) with 27-nt G-rich strand (G/c-MYC), its equimolar mixture with the complementary sequence (GC/c-MYC) and related C-rich oligonucleotide (C/c-MYC) is investigated.	Water	25-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	169-174
33132901-7	2020	Results: In comparison with wild-type mice, APP/PS1 mice exhibited significant cognitive deficits, represented with poor performance in novel object recognition and Morris water maze tests, downregulated GLT-1 expression and glutamate uptake.	Water	172-177	presenilin 1	Mus musculus	48-51
24636993-9	2014	These results demonstrate that GATA2 regulates the Aqp2 gene expression in CD cells and contributes to the maintenance of the body water homeostasis.	Water	131-136	aquaporin 2	Mus musculus	51-55
24412547-10	2014	CONCLUSIONS: Sennoside A may decrease AQP3 expression in the colon to inhibit water transport from the luminal to the vascular side, leading to a laxative effect.	Water	78-83	aquaporin 3 (Gill blood group)	Homo sapiens	38-42
33036186-1	2020	As an important carrier for intestinal secretion and water absorption, aquaporin 3 (AQP3) is closely related to diarrhea.	Water	53-58	aquaporin 3 (Gill blood group)	Homo sapiens	71-82
24586644-6	2014	Administration of recombinant IL-22 during the late phase, but not the early phase, of EAU increased EAU clinical scores in T cell-specific Rbpj-deficient mice.	Water	87-90	interleukin 22	Mus musculus	30-35
24586644-6	2014	Administration of recombinant IL-22 during the late phase, but not the early phase, of EAU increased EAU clinical scores in T cell-specific Rbpj-deficient mice.	Water	101-104	interleukin 22	Mus musculus	30-35
24180631-0	2014	S-propargyl-cysteine, a novel water-soluble modulator of endogenous hydrogen sulfide, promotes angiogenesis through activation of signal transducer and activator of transcription 3.	Water	30-35	signal transducer and activator of transcription 3	Rattus norvegicus	130-180
24773584-2	2014	When water was employed as the proton source (10 M in MeCN), CO was produced (fCO= 45% +- 6.4) near the Co(I/0) redox couple for [Co(III)N4H(Br)2](+) (E1/2 = -1.88 V FeCp2(+/0)) with simultaneous H2 evolution (fH2= 30% +- 7.8).	Water	5-10	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	104-110
33036186-1	2020	As an important carrier for intestinal secretion and water absorption, aquaporin 3 (AQP3) is closely related to diarrhea.	Water	53-58	aquaporin 3 (Gill blood group)	Homo sapiens	84-88
24029391-1	2014	BACKGROUND AND PURPOSE: ADC provides a measure of water molecule diffusion in tissue.	Water	50-55	antizyme inhibitor 2	Homo sapiens	24-27
32799672-1	2020	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel protein responsible for water reabsorption by the kidney collecting ducts.	Water	46-51	aquaporin 2	Mus musculus	0-11
24170587-2	2014	Here we demonstrate the application of a water/alcohol soluble CPE (CPE-K) as HTLs in BHJ solar cells, achieving a PCE up to 8.2%.	Water	41-46	carboxypeptidase E	Homo sapiens	63-66
32799672-1	2020	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel protein responsible for water reabsorption by the kidney collecting ducts.	Water	46-51	aquaporin 2	Mus musculus	13-17
24170587-2	2014	Here we demonstrate the application of a water/alcohol soluble CPE (CPE-K) as HTLs in BHJ solar cells, achieving a PCE up to 8.2%.	Water	41-46	carboxypeptidase E	Homo sapiens	68-73
32799672-1	2020	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel protein responsible for water reabsorption by the kidney collecting ducts.	Water	84-89	aquaporin 2	Mus musculus	0-11
32799672-1	2020	Aquaporin-2 (AQP2) is a vasopressin-regulated water channel protein responsible for water reabsorption by the kidney collecting ducts.	Water	84-89	aquaporin 2	Mus musculus	13-17
24338365-7	2014	Finally, using a specific small-interfering RNA against the endogenous aquaporin AQP3, the water transport accompanying CFTR activity decreased.	Water	91-96	aquaporin 3 (Gill blood group)	Homo sapiens	81-85
24885203-2	2014	We recently demonstrated that high calcium delivery to the collecting duct reduces local Aquaporin-2 (AQP2) mediated water reabsorption under vasopressin action, thus limiting the maximal urinary concentration and reducing calcium saturation.	Water	117-122	aquaporin 2	Homo sapiens	89-100
24885203-2	2014	We recently demonstrated that high calcium delivery to the collecting duct reduces local Aquaporin-2 (AQP2) mediated water reabsorption under vasopressin action, thus limiting the maximal urinary concentration and reducing calcium saturation.	Water	117-122	aquaporin 2	Homo sapiens	102-106
32799672-2	2020	Under control conditions, most AQP2 resides in the recycling endosomes of the principal cells where it answers to vasopressin with trafficking to the apical plasma membrane to increase water reabsorption.	Water	185-190	aquaporin 2	Mus musculus	31-35
32702805-0	2020	Pb2+ and Cd2+ recovery from water using residual tea waste and SiO2@TW nanocomposites.	Water	28-33	CD2 molecule	Homo sapiens	9-12
24818961-12	2014	The increase in peritumoral staining for both SP and the NK1 receptor, coupled with the reduction in brain water content and BBB permeability seen following treatment with the NK1 antagonist Emend, suggests that SP plays a role in the genesis of peritumoral edema, and thus warrants further investigation as a potential anti-edematous treatment.	Water	107-112	tachykinin 1	Mus musculus	57-60
24818961-12	2014	The increase in peritumoral staining for both SP and the NK1 receptor, coupled with the reduction in brain water content and BBB permeability seen following treatment with the NK1 antagonist Emend, suggests that SP plays a role in the genesis of peritumoral edema, and thus warrants further investigation as a potential anti-edematous treatment.	Water	107-112	tachykinin 1	Mus musculus	212-214
24753570-6	2014	Intermediate-complexity climate model simulations suggest that enhanced oceanic heat transport in the South Pacific, driven by deep-water formation in the Ross Sea, was largely responsible for the observed SST gradient.	Water	132-137	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	160-163
24702591-1	2014	Efficient Rh(II)-catalyzed three-component reactions of 3-diazooxindoles and formaldehyde with either anilines or water were developed to give a series of substituted 3-amino-3-hydroxymethyloxindoles or 3-hydroxy-3-hydroxymethyloxindoles in good to excellent yields.	Water	114-119	Rh blood group D antigen	Homo sapiens	10-17
24424055-4	2014	Expression of EDN1 and one of its receptors, EDNRAa, was stimulated in zebrafish acclimated to acidic water.	Water	102-107	endothelin 1	Danio rerio	14-18
24733887-1	2014	Human aquaporin 2 (AQP2) is a water channel found in the kidney collecting duct, where it plays a key role in concentrating urine.	Water	30-35	aquaporin 2	Homo sapiens	6-17
24733887-1	2014	Human aquaporin 2 (AQP2) is a water channel found in the kidney collecting duct, where it plays a key role in concentrating urine.	Water	30-35	aquaporin 2	Homo sapiens	19-23
24733887-2	2014	Water reabsorption is regulated by AQP2 trafficking between intracellular storage vesicles and the apical membrane.	Water	0-5	aquaporin 2	Homo sapiens	35-39
26274467-1	2014	The direct evidence of confined water ("water pocket") inside hydrophilic room-temperature ionic liquids (RTILs) was obtained by complementary use of small-angle X-ray scattering and small-angle neutron scattering (SAXS and SANS).	Water	32-37	USH1 protein network component sans	Homo sapiens	224-228
26274467-1	2014	The direct evidence of confined water ("water pocket") inside hydrophilic room-temperature ionic liquids (RTILs) was obtained by complementary use of small-angle X-ray scattering and small-angle neutron scattering (SAXS and SANS).	Water	40-45	USH1 protein network component sans	Homo sapiens	224-228
26274467-4	2014	Both water concentration and temperature dependence of the peaks in SANS profiles confirmed the existence of the hidden water pocket.	Water	5-10	USH1 protein network component sans	Homo sapiens	68-72
26274467-4	2014	Both water concentration and temperature dependence of the peaks in SANS profiles confirmed the existence of the hidden water pocket.	Water	120-125	USH1 protein network component sans	Homo sapiens	68-72
26274467-5	2014	The size of the water pocket was estimated to be ~3 nm, and D2O aggregations were well-simulated on the basis of the observed SANS data.	Water	16-21	USH1 protein network component sans	Homo sapiens	126-130
24699735-4	2014	The TSH2B Ser85 residue does not interact with H4 in the nucleosome, but in the canonical nucleosome the H2B Asn84 residue (corresponding to the TSH2B Ser85 residue) forms water-mediated hydrogen bonds with the H4 Arg78 residue.	Water	172-177	H2B clustered histone 1	Homo sapiens	4-9
24699735-4	2014	The TSH2B Ser85 residue does not interact with H4 in the nucleosome, but in the canonical nucleosome the H2B Asn84 residue (corresponding to the TSH2B Ser85 residue) forms water-mediated hydrogen bonds with the H4 Arg78 residue.	Water	172-177	H2B clustered histone 21	Homo sapiens	6-9
24699735-4	2014	The TSH2B Ser85 residue does not interact with H4 in the nucleosome, but in the canonical nucleosome the H2B Asn84 residue (corresponding to the TSH2B Ser85 residue) forms water-mediated hydrogen bonds with the H4 Arg78 residue.	Water	172-177	H2B clustered histone 1	Homo sapiens	145-150
24500432-0	2014	Effects of beta-hydroxy-beta-methylbutyrate free acid and cold water immersion on expression of CR3 and MIP-1beta following resistance exercise.	Water	63-68	C-C motif chemokine ligand 4	Homo sapiens	104-113
24491342-4	2014	Sulfamethoxazole was almost completely removed from water by zeolite Y and MOR in a few minutes.	Water	52-57	opioid receptor mu 1	Homo sapiens	75-78
24200567-2	2014	The aim of this study was to assay DPP-IV inhibitory peptides that can be present in a water soluble extract of Spanish dry-cured ham.	Water	87-92	dipeptidyl peptidase 4	Homo sapiens	35-41
24459270-1	2014	The Salton Sea is the largest inland body of water in California, with salinities ranging from brackish freshwater to hypersaline.	Water	45-50	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	11-14
24466344-1	2014	The final control of renal water reabsorption occurs in the collecting duct (CD) and relies on regulated expression of aquaporin-2 (AQP2) in principal CD cells.	Water	27-32	aquaporin 2	Homo sapiens	119-130
24466344-1	2014	The final control of renal water reabsorption occurs in the collecting duct (CD) and relies on regulated expression of aquaporin-2 (AQP2) in principal CD cells.	Water	27-32	aquaporin 2	Homo sapiens	132-136
25669355-3	2014	The method can reproduce the corrections to the MP2/cc-pVTZ energies of H2O, CH4, and C6H6 within a few mEh after several million MC steps.	Water	72-75	tryptase pseudogene 1	Homo sapiens	48-51
24331413-0	2014	Hydrogen-rich water regulates cucumber adventitious root development in a heme oxygenase-1/carbon monoxide-dependent manner.	Water	14-19	heme oxygenase 1, chloroplastic	Cucumis sativus	74-90
24060142-4	2014	COST Action 869 was an EU initiative to improve surface water quality that ran from 2006 to 2011, in which 30 countries participated.	Water	56-61	RAN, member RAS oncogene family	Homo sapiens	75-78
24410213-6	2014	The occurrence of this effect at low Ecm indicates that the long range charge and dipole-induced-multipole interactions of the colliding pair play a significant role in the dynamics of the exothermic H2O(+) + H2 (D2) reactions.	Water	200-203	multimerin 1	Homo sapiens	37-40
24148241-0	2014	Water-soluble drug partitioning and adsorption in HEMA/MAA hydrogels.	Water	0-5	MAA	Homo sapiens	55-58
25521245-7	2014	RESULTS: Bhageerath-H web-server was validated on 75 CASP10 targets which showed TM-scores &gt;= 0.5 in 91% of the cases and Calpha RMSDs &lt;= 5 A from the native in 58% of the targets, which is well above the CASP10 water mark.	Water	218-223	caspase 10	Homo sapiens	53-59
25521245-7	2014	RESULTS: Bhageerath-H web-server was validated on 75 CASP10 targets which showed TM-scores &gt;= 0.5 in 91% of the cases and Calpha RMSDs &lt;= 5 A from the native in 58% of the targets, which is well above the CASP10 water mark.	Water	218-223	caspase 10	Homo sapiens	211-217
24717924-11	2014	AQP3 and AQP9 facilitate both transcellular osmotic water flow and glycerol transport as pore-like passive transporters in the keratinocytes of oral epithelia, and may play a key role in not only hydration and the permeability barrier, but also cell proliferation, differentiation, migration, development, and wound healing by generating ATP.	Water	52-57	aquaporin 3 (Gill blood group)	Rattus norvegicus	0-4
24415829-2	2014	It was found that the introduction of methanol as co-solvent (35 wt%) to the medium greatly decreases the amount of water-soluble polyelectrolyte in the cases NaAA and Na2ita while it does not make difference for NaSS and NaAmps.	Water	116-121	N-acylethanolamine acid amidase	Homo sapiens	159-163
24655000-7	2014	The water-soluble forms of the HO-1 inhibitor Zinc protoporphyrin (ZnPP) have seemed promising in different in-vivo models, in which it has induced growth arrest in tumour cells with few, if any, side effects.	Water	4-9	heme oxygenase 1	Homo sapiens	31-35
24695276-1	2014	Folic acid (FA) is a water-soluble vitamin, and orally ingested FA is absorbed from the small intestine by the proton-coupled folate transporter (PCFT).	Water	21-26	solute carrier family 46 member 1	Homo sapiens	146-150
24391740-1	2013	Urotensin-II controls ion/water homeostasis in fish and vascular tone in rodents.	Water	26-31	urotensin 2	Homo sapiens	0-12
24501585-0	2013	Enhanced water splitting by Fe2O3-TiO2-FTO photoanode with modified energy band structure.	Water	9-14	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	39-42
24081178-3	2013	In the presence of the reducing agents, the diaqua-Ru2 species first undergo a ligand substitution reaction by which the axially-coordinated water is displaced by the reducing agent.	Water	141-146	doublecortin domain containing 2	Homo sapiens	51-54
24041145-4	2013	The trace metal impurities in ACS grade salt, which are more abundant than those in UP grade salt, are responsible for this difference due to their stronger affinity for the carboxylate group relative to Na(+) and further affects the interfacial water structure.	Water	246-251	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	30-33
24224908-1	2013	The OD stretch of dilute HOD in H2O absorbed in a series of sulfonated syndiotactic poly(styrene) and sulfonated poly(sulfone) membranes was studied using FTIR spectroscopy to measure how the character of the sulfonate head group and the backbone polarity influenced the water-membrane interactions.	Water	32-35	HOP homeobox	Homo sapiens	25-28
24224908-1	2013	The OD stretch of dilute HOD in H2O absorbed in a series of sulfonated syndiotactic poly(styrene) and sulfonated poly(sulfone) membranes was studied using FTIR spectroscopy to measure how the character of the sulfonate head group and the backbone polarity influenced the water-membrane interactions.	Water	271-276	HOP homeobox	Homo sapiens	25-28
23584881-2	2013	Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2).	Water	0-5	aquaporin 2	Homo sapiens	89-100
23584881-2	2013	Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2).	Water	0-5	aquaporin 2	Homo sapiens	102-106
23584881-2	2013	Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2).	Water	74-79	aquaporin 2	Homo sapiens	89-100
23584881-2	2013	Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2).	Water	74-79	aquaporin 2	Homo sapiens	102-106
24144811-2	2013	The molecular mechanism of the deactivation of the enzyme by methanol was investigated by fitting the experimental data to a kinetic model and by molecular dynamics simulations of C. antarctica lipase B in toluene-methanol-water mixtures.	Water	223-228	PAN0_003d1715	Moesziomyces antarcticus	194-200
24055251-2	2013	Sweep flocculation (enmeshment and adsorption) with Alc is the most dominant mechanism contributing to the nC60 removal in pure water.	Water	128-133	allantoicase	Homo sapiens	52-55
23948391-9	2013	Significant lower amounts of Candida albicans for tablet storage compared to water preservation were recorded in dBF and mBF (-69.3 +- 3.8% and -75.9 +- 3.2% respectively).	Water	77-82	rhotekin 2	Mus musculus	121-124
23934865-1	2013	In addition to protein-protein docking, this CAPRI edition included new challenges, like protein-water and protein-sugar interactions, or the prediction of binding affinities and DeltaDeltaG changes upon mutation.	Water	97-102	RAS p21 protein activator 4	Homo sapiens	45-50
24224801-1	2013	New technology has been developed that enables Suzuki-Miyaura couplings involving widely utilized MIDA boronates to be run in water as the only medium, mainly at room temperature.	Water	126-131	NADH:ubiquinone oxidoreductase complex assembly factor 7	Homo sapiens	98-102
24121499-2	2013	We present evidence that either apoC-I or apoC-III, when bound to triglyceride-rich lipoproteins, prevent binding of LPL to the lipid/water interface.	Water	134-139	apolipoprotein C3	Homo sapiens	42-50
24121499-2	2013	We present evidence that either apoC-I or apoC-III, when bound to triglyceride-rich lipoproteins, prevent binding of LPL to the lipid/water interface.	Water	134-139	lipoprotein lipase	Homo sapiens	117-120
24121499-8	2013	In the presence of the LPL activator protein apoC-II, more of apoC-I or apoC-III was needed for displacement of LPL from the lipid/water interface.	Water	131-136	lipoprotein lipase	Homo sapiens	23-26
24121499-8	2013	In the presence of the LPL activator protein apoC-II, more of apoC-I or apoC-III was needed for displacement of LPL from the lipid/water interface.	Water	131-136	apolipoprotein C3	Homo sapiens	72-80
24121499-8	2013	In the presence of the LPL activator protein apoC-II, more of apoC-I or apoC-III was needed for displacement of LPL from the lipid/water interface.	Water	131-136	lipoprotein lipase	Homo sapiens	112-115
32702805-1	2020	This work reports the fabrication of SiO2@TW nanocomposites and their application for Pb2+ and Cd2+ ions sequestration from simulated water.	Water	134-139	CD2 molecule	Homo sapiens	95-98
32702805-5	2020	The experiments were carried out in batch mode to explore the effect of various operating parameters on the sequestration of Pb2+ and Cd2+ ions from water.	Water	149-154	CD2 molecule	Homo sapiens	134-137
32581050-0	2020	Centella asiatica water extract shows low potential for CYP-mediated drug interactions.	Water	18-23	peptidylprolyl isomerase G	Homo sapiens	56-59
24070677-1	2013	The membrane-bound water channel aquaporin-4 (AQP4) plays a significant role in maintaining brain water homeostasis.	Water	19-24	aquaporin 4	Rattus norvegicus	46-50
24070677-1	2013	The membrane-bound water channel aquaporin-4 (AQP4) plays a significant role in maintaining brain water homeostasis.	Water	98-103	aquaporin 4	Rattus norvegicus	46-50
23813972-10	2013	Observed water-flux through SLC4A11 extends the repertoire of known water movement pathways and call for a re-examination of explanations for water movement in human tissues.	Water	68-73	solute carrier family 4 member 11	Homo sapiens	28-35
23813972-10	2013	Observed water-flux through SLC4A11 extends the repertoire of known water movement pathways and call for a re-examination of explanations for water movement in human tissues.	Water	68-73	solute carrier family 4 member 11	Homo sapiens	28-35
32312181-6	2020	Inhibition of TGFBR1 led to active inhabitable electrolyte and water transport by primary human renal tubule epithelial cells in vitro.	Water	63-68	transforming growth factor beta receptor 1	Homo sapiens	14-20
23995846-7	2013	The lability of the system has also enabled the association in dimers of the acetato derivative, i.e. [Mo3S4(eta(2)-dtp)3(eta(2)(mu)-AcO)(H2O)], via a pyrazine bridging ligand.	Water	138-141	kallikrein related peptidase 15	Homo sapiens	133-136
32412103-9	2020	Furthermore, data acquired from Morris water maze (MWM) testing indicated that IL-4 administration could ameliorate cognitive impairment in the AD mice.	Water	39-44	interleukin 4	Mus musculus	79-83
24320260-7	2013	Maximum deviations between CCSD(T) and 3-body:Many-body CCSD(T):MP2 frequencies are typically only a few tenths of a cm(-1) for the H2O clusters examined in this work.	Water	132-135	tryptase pseudogene 1	Homo sapiens	64-67
32784075-1	2020	The Syr Darya is one of two major rivers in Central Asia supplying critical fresh water to the Aral Sea.	Water	82-87	YES1 pseudogene 1	Homo sapiens	4-7
24371394-6	2013	IL-4 production and Th2 cell differentiation showed a decreasing tendency with mineral water bathing, but the Th1 cells did not.	Water	87-92	interleukin 4	Mus musculus	0-4
24371394-6	2013	IL-4 production and Th2 cell differentiation showed a decreasing tendency with mineral water bathing, but the Th1 cells did not.	Water	87-92	heart and neural crest derivatives expressed 2	Mus musculus	20-23
24564515-4	2014	In the present study, we introduced lipase B from Candida antarctica into a bicontinuous microemulsion of composition H2O/NaCl-n-octane-pentaethylene glycol monodecylether (C10E5).	Water	118-121	PAN0_003d1715	Moesziomyces antarcticus	36-42
24564515-6	2014	Phase diagrams showed a maximum in efficiency with increasing amount of lipase added to the water phase of the microemulsion.	Water	92-97	PAN0_003d1715	Moesziomyces antarcticus	72-78
32784075-3	2020	The primary goal of this investigation was to determine seasonal variations in ambient concentrations of modern and legacy pesticides in bottom sediment and water of the Syr Darya in Kazakhstan (KZ) downstream from an agriculturally-intensive watershed in Uzbekistan.	Water	157-162	YES1 pseudogene 1	Homo sapiens	170-173
23859875-4	2013	The air/water interface was used as confinement for the self-assembling process of dU11.	Water	8-13	small nuclear RNA U11	Drosophila melanogaster	83-87
32893622-2	2020	The adducts between ARP and EGCG were identified as two ARP-EGCG isomers, two ARP-EGCG-H2O isomers, and multiple ARP-deoxypentosone (DP)-EGCG isomers.	Water	87-90	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	20-23
23994016-8	2013	In conclusion, water-mediated solid-state PITs of amorphous PRX is evident during aqueous-based drug-layer coating of pellets, and solid-state change can be verified using Raman spectroscopy.	Water	15-20	periaxin	Homo sapiens	60-63
24452376-9	2014	Thus AQP3-EGFP diffusion is altered upon increased cAMP, which may correspond to basolateral adaptations in response to the increased apical water readsorption.	Water	141-146	aquaporin 3 (Gill blood group)	Homo sapiens	5-9
24497294-3	2014	METHODS: The DIC-CO2-GEM measures both delta(18)OH2O and delta(13)CDIC values concurrently by combining the fundamental principles of the classic CO2-H2O equilibration and gas evolution methods, respectively.	Water	49-52	complement C2	Homo sapiens	17-20
33101251-3	2020	The sanitizer electrolyzed-water (EW) retained partial fungicidal activity against the food-spoilage fungus Aspergillus niger at high levels of added soils (30-750 mg mL-1), commonly associated with harvested produce.	Water	27-32	L1 cell adhesion molecule	Mus musculus	167-171
24384370-5	2014	These findings demonstrate that Calhm1 KO mice, like T1r3 KO mice and WT mice, are sensitive to the post-oral preference conditioning actions of sucrose and can discriminate sugar from water.	Water	185-190	calcium homeostasis modulator 1	Mus musculus	32-38
24276616-5	2013	In this study, we computationally analyzed the role of this water molecule as a putative hydrogen bond donor/acceptor moiety in the agonist binding site of the three most relevant heteromeric (alpha4beta2, alpha3beta4) and homomeric (alpha7) neuronal nicotinic acetylcholine receptor (nAChR) subtypes.	Water	60-65	cholinergic receptor nicotinic alpha 7 subunit	Homo sapiens	234-283
24006421-0	2013	Overexpression of the poplar NF-YB7 transcription factor confers drought tolerance and improves water-use efficiency in Arabidopsis.	Water	96-101	nuclear factor Y, subunit B7	Arabidopsis thaliana	29-35
24606771-1	2014	BACKGROUND: Aquaporin (AQP) proteins function in transporting water and other small molecules through the biological membranes, which is crucial for plants to survive in drought or salt stress conditions.	Water	62-67	probable aquaporin PIP1-2	Musa acuminata	12-21
33036527-8	2020	After c-myc silenced cells were treated with PM2.5 water soluble solution, The mRNA levels of c-myc, c-fos, and k-ras decreased by 84.1%, 45.4%, and 54.6% (P<0.05) , p53 increased by 192.9% (P<0.05) , and the expression of Caspase-3, Caspase-8, and Caspase-9 decreased by 24.4%, 36.1%, 60.9% (P<0.05) .	Water	51-56	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	6-11
24606771-1	2014	BACKGROUND: Aquaporin (AQP) proteins function in transporting water and other small molecules through the biological membranes, which is crucial for plants to survive in drought or salt stress conditions.	Water	62-67	probable aquaporin PIP1-2	Musa acuminata	23-26
24412302-8	2014	Post-docking intramolecular hydrogen bonding analysis shows water molecule mediated hydrogen bonding for N-terminal maltase glucoamylase and N-terminal sucrase isomaltase.	Water	60-65	sucrase-isomaltase	Rattus norvegicus	152-170
24029921-0	2013	Synthesis of ultrathin CdS nanosheets as efficient visible-light-driven water splitting photocatalysts for hydrogen evolution.	Water	72-77	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
24030544-0	2013	Efficient photocatalytic hydrogen production in water using a cobalt(III) tetraaza-macrocyclic catalyst: electrochemical generation of the low-valent Co(I) species and its reactivity toward proton reduction.	Water	48-53	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	150-155
33036527-8	2020	After c-myc silenced cells were treated with PM2.5 water soluble solution, The mRNA levels of c-myc, c-fos, and k-ras decreased by 84.1%, 45.4%, and 54.6% (P<0.05) , p53 increased by 192.9% (P<0.05) , and the expression of Caspase-3, Caspase-8, and Caspase-9 decreased by 24.4%, 36.1%, 60.9% (P<0.05) .	Water	51-56	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
33036527-8	2020	After c-myc silenced cells were treated with PM2.5 water soluble solution, The mRNA levels of c-myc, c-fos, and k-ras decreased by 84.1%, 45.4%, and 54.6% (P<0.05) , p53 increased by 192.9% (P<0.05) , and the expression of Caspase-3, Caspase-8, and Caspase-9 decreased by 24.4%, 36.1%, 60.9% (P<0.05) .	Water	51-56	caspase 9	Homo sapiens	249-258
24204563-0	2013	Identification of thyroid receptor ant/agonists in water sources using mass balance analysis and monte carlo simulation.	Water	51-56	solute carrier family 25 member 6	Homo sapiens	35-38
32939585-7	2020	This newly developed sensor has good stability and selectivity, and has been successfully applied to the As3+ determination of four kinds of water quality.	Water	141-146	PDS5 cohesin associated factor B	Homo sapiens	105-108
23823878-9	2013	An increase in area per lipid headgroup leads to an increase in the level of alpha-synuclein adsorption with a reduced water content in the acyl chain layer.	Water	119-124	synuclein alpha	Homo sapiens	77-92
24352411-5	2014	Water deprivation resulted in increased TRPC4 mRNA expression in the PVN, while it decreased channel expression levels in the SON.	Water	0-5	transient receptor potential cation channel, subfamily C, member 4	Rattus norvegicus	40-45
24352504-5	2014	In polarized mouse cortical collecting duct (mpkCCD) cells, HCTZ treatment attenuated the Li-induced downregulation of aquaporin-2 (AQP2) water channel abundance.	Water	138-143	aquaporin 2	Mus musculus	119-130
24352504-5	2014	In polarized mouse cortical collecting duct (mpkCCD) cells, HCTZ treatment attenuated the Li-induced downregulation of aquaporin-2 (AQP2) water channel abundance.	Water	138-143	aquaporin 2	Mus musculus	132-136
32932769-3	2020	In this study, we examined the mechanism by which astaxanthin improves skin function by focusing on the water channel aquaporin-3 (AQP3), which plays important roles in maintaining skin moisture and function.	Water	104-109	aquaporin 3 (Gill blood group)	Homo sapiens	131-135
24098965-3	2013	Small water droplets with a volume larger than 0.3 muL can slide on the CNTs/Si-mup with a tilted angle of approximately 5 .	Water	6-11	major urinary protein, pseudogene	Homo sapiens	80-83
24098965-5	2013	However, the CNTs/Si-mup still show superhydrophobic properties even after wetting using tiny water droplets.	Water	94-99	major urinary protein, pseudogene	Homo sapiens	21-24
32706253-3	2020	Both results are of utmost importance for simultaneous applications in tumor resection and post-resection treatment of remaining unresected margins, thanks to a molecular construct designed to raise its light collection efficiency (i.e., CR energy transfer) by conjugation with multiple CR-absorbing (water-soluble) antenna followed by intramolecular-FRET/TBET energy transfers.	Water	301-306	T-box transcription factor 21	Homo sapiens	356-360
24092542-2	2013	It is demonstrated that two H2 O molecules coordinate to [Cp*2 Ti(III) (OTf)] subsequently forming [Cp2 *Ti(III) (H2 O)(OTf)] and [Cp*Ti(III) (H2 O)2 (OTf)].	Water	28-32	ceruloplasmin	Homo sapiens	100-103
23941864-8	2014	Also, the resulting water phase led to an increase in INa (+19%; n = 17; P &lt; 0.001 vs. bupivacaine), demonstrating that part of the bupivacaine had been removed during ultracentrifugation.	Water	20-25	internexin neuronal intermediate filament protein, alpha	Rattus norvegicus	54-57
24586644-5	2014	The amelioration of EAU in T cell-specific Rbpj-deficient mice correlated with low levels of IL-22 production from CD4(+) T cells, although IRBP-specific CD4(+) T cell proliferation and Th17 differentiation were unaffected.	Water	20-23	recombination signal binding protein for immunoglobulin kappa J region	Mus musculus	43-47
32995104-2	2020	We propose that pyramiding AVP1 and MIOX4 genes will further improve stress tolerance under water-limited and salt-stress conditions.	Water	92-97	Inorganic H pyrophosphatase family protein	Arabidopsis thaliana	27-31
24432790-3	2014	We have developed a protocol to include water molecules that mediate ligand-protein interactions as part of the protein structure in calculation of MM/PBSA binding energies (a method we refer to as water-MM/PBSA) for a series of JNK3 kinase inhibitors.	Water	40-45	mitogen-activated protein kinase 10	Homo sapiens	229-233
24432790-3	2014	We have developed a protocol to include water molecules that mediate ligand-protein interactions as part of the protein structure in calculation of MM/PBSA binding energies (a method we refer to as water-MM/PBSA) for a series of JNK3 kinase inhibitors.	Water	198-203	mitogen-activated protein kinase 10	Homo sapiens	229-233
23677388-3	2013	AQP3 and AQP10 are aqua-glyceroporins, known to transport glycerol as well as water.	Water	78-83	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
33013877-6	2020	Further Treg-enrichment (~80%) of the AgX population indicated FoxP3+CD25hiCD4+ Treg played a key role in EAU-suppression while FoxP3-CD25lo/-CD4+ T cells did not.	Water	106-109	forkhead box P3	Mus musculus	63-68
24116529-0	2013	The North Pacific Acoustic Laboratory deep-water acoustic propagation experiments in the Philippine Sea.	Water	43-48	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	100-103
24022347-6	2014	Verapamil hydrochloride tablets prepared using silicone PSA showed higher hydrophobicity and lower water uptake than EC tablets.	Water	99-104	aminopeptidase puromycin sensitive	Homo sapiens	56-59
32442719-7	2020	Such regulation of RAV1 gene expression seems vital as absence of RAV1 leads to reduced water loss during dehydration stress and consequently faster recovery compared to wild type.	Water	88-93	related to ABI3/VP1 1	Arabidopsis thaliana	19-23
24337738-3	2014	In an acute AD model, skin transepidermal water loss was significantly attenuated in EGF-treated mice.	Water	42-47	epidermal growth factor	Mus musculus	85-88
23810860-9	2013	Four principal components (PCs) were extracted from PCA, which explain 80.86% of the total parameters in water chemistry: PC1, the seawater intrusion and As contamination; PC2, the water-rock interaction, surface water recharge and acidic precipitation; PC3, heavy metal pollution from industry; and PC4, agricultural pollution and sewage intrusion.	Water	105-110	proprotein convertase subtilisin/kexin type 1	Homo sapiens	122-125
23810860-9	2013	Four principal components (PCs) were extracted from PCA, which explain 80.86% of the total parameters in water chemistry: PC1, the seawater intrusion and As contamination; PC2, the water-rock interaction, surface water recharge and acidic precipitation; PC3, heavy metal pollution from industry; and PC4, agricultural pollution and sewage intrusion.	Water	105-110	chromobox 4	Homo sapiens	172-175
23810860-9	2013	Four principal components (PCs) were extracted from PCA, which explain 80.86% of the total parameters in water chemistry: PC1, the seawater intrusion and As contamination; PC2, the water-rock interaction, surface water recharge and acidic precipitation; PC3, heavy metal pollution from industry; and PC4, agricultural pollution and sewage intrusion.	Water	105-110	proprotein convertase subtilisin/kexin type 1	Homo sapiens	254-257
24356448-6	2014	The observed down-regulation of both the expression and water channel activity of AQP4 is likely to originate from a dominant-negative effect caused by heterodimerization between AQP4 and AQP4-Delta4, which was detected in coimmunoprecipitation studies.	Water	56-61	delta like canonical Notch ligand 4	Homo sapiens	193-199
32442719-7	2020	Such regulation of RAV1 gene expression seems vital as absence of RAV1 leads to reduced water loss during dehydration stress and consequently faster recovery compared to wild type.	Water	88-93	related to ABI3/VP1 1	Arabidopsis thaliana	66-70
23964651-5	2013	We apply this tool to the naturally unfolded protein human alpha-synuclein interacting with dopamine, an inhibitor of fibril formation, and with its oxidation products in water solutions.	Water	171-176	synuclein alpha	Homo sapiens	59-74
23964651-6	2013	By coupling 2D NMR experiments with MD simulations of the adducts in explicit water, the tool confirms with experimental data that the ligands bind preferentially to (125)YEMPS(129) residues in the C-terminal region and to a few residues of the so-called NAC region consistently.	Water	78-83	synuclein alpha	Homo sapiens	255-258
32786602-5	2020	Orthogonal partial least squares and multiple linear regression analyses identified the spectral slope coefficient from 290 to 400 nm (S290-400) as the most effective predictor of Fapp,RI among measured water chemistry parameters and bulk DOM properties.	Water	203-208	carboxyl ester lipase	Homo sapiens	180-184
24058510-1	2013	Aquaporin-3 (AQP3) and aquaporin-4 (AQP4) are homologous proteins expressed in the basolateral plasma membrane of kidney collecting duct principal cells, where they mediate the exit pathway for apically reabsorbed water.	Water	214-219	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
24058510-1	2013	Aquaporin-3 (AQP3) and aquaporin-4 (AQP4) are homologous proteins expressed in the basolateral plasma membrane of kidney collecting duct principal cells, where they mediate the exit pathway for apically reabsorbed water.	Water	214-219	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
24081304-3	2014	We found that water maze training downregulated STAT1 expression in the rat hippocampal CA1 area, and spatial learning and memory function was enhanced in Stat1-knockout mice.	Water	14-19	carbonic anhydrase 1	Rattus norvegicus	88-91
32786602-6	2020	Fapp,RI also exhibited divergent responses to controlled pH adjustment and aluminum or iron addition simulating hypothetical scenarios relevant to past and future water chemistry conditions of Adirondack lakes.	Water	163-168	carboxyl ester lipase	Homo sapiens	0-4
23742973-3	2013	The water solubility of Indo-Pep under weakly acidic and neutral conditions is much higher than that of Indo alone.	Water	4-9	progestagen associated endometrial protein	Homo sapiens	29-32
32498835-4	2020	The results indicated that probes C1 and C3 exhibited strong AIE property in DMF/H2O (1:1, v/v) mixture system with brilliant yellow fluorescence emission (560 nm) observed under 365 nm UV lamp.	Water	81-84	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	34-43
24015756-6	2013	This evidence for the positive selection of AQP2 and SLC14A2 suggests that the adaptive evolution of these genes has helped to enhance the capacity for water and urea transport, thereby leading to the concentration of urine, which is an efficient mechanism for maintaining the water balance.	Water	152-157	aquaporin 2	Homo sapiens	44-48
24338963-9	2014	The qualitative and quantitative parameters determined in the validation process indicate that the presented analytical procedure can be applied for the determination of AsB, As(III), DMA, MMA and As(V) in water.	Water	206-211	arylsulfatase B	Homo sapiens	170-173
24392972-4	2014	The resultant water-soluble PAH-modified GNs (GNs-PAH) in conjunction with tailor-made negatively charged CdS quantum dots (QDs) were utilized as nanobuilding blocks for sequential layer-by-layer (LbL) self-assembly of well-defined GNs-CdS QDs hybrid films, in which CdS QDs overspread evenly on the two-dimensional (2D) GNs.	Water	14-19	CDP-diacylglycerol synthase 1	Homo sapiens	236-239
24392972-4	2014	The resultant water-soluble PAH-modified GNs (GNs-PAH) in conjunction with tailor-made negatively charged CdS quantum dots (QDs) were utilized as nanobuilding blocks for sequential layer-by-layer (LbL) self-assembly of well-defined GNs-CdS QDs hybrid films, in which CdS QDs overspread evenly on the two-dimensional (2D) GNs.	Water	14-19	CDP-diacylglycerol synthase 1	Homo sapiens	236-239
32498835-5	2020	The experiments of sensing indicated that probes C1 and C3 possessed the sequentially detecting abilities for hydrazine with high sensitivity, specificity as well as an extremely low detection limit (55.1 nM), which was due to blocking of AIE process of probes C1 and C3 by special chemical reaction (-CHN- moiety transformed into -CH2-NH- group) after hydrazine addition, resulting in the increase in water solubility and a weak emission in aqueous media.	Water	402-407	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	49-58
23868443-5	2013	The discrepancy between the hydration pictures derived from the water R1(omega0)-NMRD profiles and MD is relevant in a discussion of the factors behind the stretched NMRD profile, the distribution of orientational order parameters and residence times of buried water used in the NMRD model.	Water	64-69	CD1b molecule	Homo sapiens	70-79
32498835-5	2020	The experiments of sensing indicated that probes C1 and C3 possessed the sequentially detecting abilities for hydrazine with high sensitivity, specificity as well as an extremely low detection limit (55.1 nM), which was due to blocking of AIE process of probes C1 and C3 by special chemical reaction (-CHN- moiety transformed into -CH2-NH- group) after hydrazine addition, resulting in the increase in water solubility and a weak emission in aqueous media.	Water	402-407	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	261-270
23868443-5	2013	The discrepancy between the hydration pictures derived from the water R1(omega0)-NMRD profiles and MD is relevant in a discussion of the factors behind the stretched NMRD profile, the distribution of orientational order parameters and residence times of buried water used in the NMRD model.	Water	261-266	CD1b molecule	Homo sapiens	70-79
33093699-0	2020	SGLT2 INHIBITORS - SOMETHING IN THE WATER, OR THE HEART OF THE MATTER?	Water	36-41	solute carrier family 5 member 2	Homo sapiens	0-5
24028122-3	2013	Our MP2/6-31G+(d) results show substantial increases of the dipole moment of both retinal derivatives in solution as compared with the gas-phase results (between 22% and 26% in chloroform and between 55% and 99% in water).	Water	215-220	tryptase pseudogene 1	Homo sapiens	4-7
24418129-6	2014	Minimum detection limits of pg mL(-1) (ppt) (0.069 ng mL(-1) for ASTM Type I water and 0.064 ng mL(-1) for seawater) and good linearity were achieved.	Water	77-82	L1 cell adhesion molecule	Mus musculus	31-37
24418129-6	2014	Minimum detection limits of pg mL(-1) (ppt) (0.069 ng mL(-1) for ASTM Type I water and 0.064 ng mL(-1) for seawater) and good linearity were achieved.	Water	77-82	L1 cell adhesion molecule	Mus musculus	54-60
24418129-6	2014	Minimum detection limits of pg mL(-1) (ppt) (0.069 ng mL(-1) for ASTM Type I water and 0.064 ng mL(-1) for seawater) and good linearity were achieved.	Water	77-82	L1 cell adhesion molecule	Mus musculus	54-60
32696649-3	2020	The present article revisites the ability of the density-functional based tight-binding (SCC-DFTB) approach to model liquids by focusing on liquid water and liquid benzene under ambient conditions.	Water	147-152	serpin family B member 3	Homo sapiens	89-92
24051295-1	2014	The intramolecular proton transfer reactions in 2-(2"-hydroxyphenyl)benzoxazole (HBO) and its naphthalene-fused analogs, (HNB1-3) in both S0 and S1 states at the PBE1PBE/6-311++G(2d,2p) level of theory in the gas phase and water have been investigated to find the effects of extension of aromaticity on the intramolecular proton transfer and photophysical properties.	Water	223-228	hereditary neuroblastoma 1	Homo sapiens	122-128
24157333-3	2014	The results indicated that the sensors S-1 and R-1 were very promising to be used as fluorescent sensors in determining the enantiomeric composition of mandelate in H2O.	Water	165-168	CD1b molecule	Homo sapiens	31-50
25606397-1	2014	Glutathione S-transferases (GSTs) belong to a super family of phase II detoxification enzymes, which play an important role in protecting cells from damage caused by endogenous and exogenous compounds by conjugating reactive intermediates with glutathione to produce less reactive water-soluble compounds.	Water	281-286	glutathione S-transferase pi 1	Homo sapiens	28-32
24280616-2	2014	Among the water samples collected from ten water sources, iodoform (CHI3) was the predominant I-THM and trace amount of chlorodiiodomethane (CHClI2) was occasionally found.	Water	10-15	chitinase 1	Homo sapiens	68-72
24417880-11	2014	In addition, continuous administration of rhodiola-water extract for 3 days in STZ-diabetic rats resulted in an increased expression of glucose transporter subtype 4 (GLUT 4) in skeletal muscle and a marked reduction of phosphoenolpyruvate carboxykinase (PEPCK) expression in liver.	Water	51-56	solute carrier family 2 member 4	Rattus norvegicus	136-165
24417880-11	2014	In addition, continuous administration of rhodiola-water extract for 3 days in STZ-diabetic rats resulted in an increased expression of glucose transporter subtype 4 (GLUT 4) in skeletal muscle and a marked reduction of phosphoenolpyruvate carboxykinase (PEPCK) expression in liver.	Water	51-56	solute carrier family 2 member 4	Rattus norvegicus	167-173
24328211-6	2014	Our findings highlight a specific role of water molecules in both CRALBP-assisted specificity toward 9-cis-retinal and its thermal isomerase activity yielding 9,13-dicis-retinal.	Water	42-47	retinaldehyde binding protein 1	Homo sapiens	66-72
24351231-2	2014	The biomolecular catalyst is made from cobalt substitution of microperoxidase-11, a water-soluble heme-undecapeptide derived from the protein horse cytochrome c.	Water	84-89	cytochrome c, somatic	Equus caballus	148-160
26276194-0	2014	Throwing Salt into the Mix: Altering Interfacial Water Structure by Electrolyte Addition.	Water	49-54	Mix paired-like homeobox	Homo sapiens	23-26
29421628-2	2014	Binding of AVP to the arginine-vasopressin receptor type-2 in the basolateral membrane leads to translocation of aquaporin-2 water channels to the apical membrane of the principal cells of the collecting duct, inducing water permeability of the membrane.	Water	125-130	aquaporin 2	Homo sapiens	113-124
29421628-2	2014	Binding of AVP to the arginine-vasopressin receptor type-2 in the basolateral membrane leads to translocation of aquaporin-2 water channels to the apical membrane of the principal cells of the collecting duct, inducing water permeability of the membrane.	Water	219-224	aquaporin 2	Homo sapiens	113-124
24583646-4	2014	The contact angle of TGF-beta2/Ti against water significantly decreased compared with untreated titanium (Ti).	Water	42-47	transforming growth factor, beta 2	Rattus norvegicus	21-30
24492673-1	2014	Aquaporin 7 (AQP7) is an aquaglyceroporin that has recently been found to operate as a facilitative carrier rather than a channel for glycerol, although its primary function is as a water channel.	Water	182-187	aquaporin-7	Canis lupus familiaris	0-11
24492673-1	2014	Aquaporin 7 (AQP7) is an aquaglyceroporin that has recently been found to operate as a facilitative carrier rather than a channel for glycerol, although its primary function is as a water channel.	Water	182-187	aquaporin-7	Canis lupus familiaris	13-17
24712668-2	2014	We report two cases of mild hyponatremia, observed in the last five years, and discuss the role played by age, sex and dose of amiodarone as well as the influence that this molecule may have on aquaporin-2 water channel expression in the renal collecting ducts.	Water	206-211	aquaporin 2	Homo sapiens	194-205
25376490-3	2014	As mammalian cells may contain hundreds of E3 ligases, identification VACM-1/cul5 as a specific subunit of the system that is expressed in the endothelium and in collecting tubules, structures known for their control of cellular permeability, may have significant implications when designing studies to elucidate the mechanism of water conservation.	Water	330-335	cullin 5	Homo sapiens	70-76
25376490-3	2014	As mammalian cells may contain hundreds of E3 ligases, identification VACM-1/cul5 as a specific subunit of the system that is expressed in the endothelium and in collecting tubules, structures known for their control of cellular permeability, may have significant implications when designing studies to elucidate the mechanism of water conservation.	Water	330-335	cullin 5	Homo sapiens	77-81
25376490-4	2014	For example, VACM-1/cul5 expression is affected by water deprivation in some tissues and there is a potential relationship between neddylated VACM-1/cul5 and aquaporins.	Water	51-56	cullin 5	Homo sapiens	13-19
25376490-4	2014	For example, VACM-1/cul5 expression is affected by water deprivation in some tissues and there is a potential relationship between neddylated VACM-1/cul5 and aquaporins.	Water	51-56	cullin 5	Homo sapiens	20-24
25376490-4	2014	For example, VACM-1/cul5 expression is affected by water deprivation in some tissues and there is a potential relationship between neddylated VACM-1/cul5 and aquaporins.	Water	51-56	cullin 5	Homo sapiens	142-148
25376490-4	2014	For example, VACM-1/cul5 expression is affected by water deprivation in some tissues and there is a potential relationship between neddylated VACM-1/cul5 and aquaporins.	Water	51-56	cullin 5	Homo sapiens	149-153
24164738-5	2014	In untreated AbetaPPswe/PS1dE9 mice, there was a dramatic and significant increase in the levels of water-soluble Abeta between 6 and 8 months, but this remained constant between 8 and 18 months.	Water	100-105	amyloid beta (A4) precursor protein	Mus musculus	13-18
24164738-6	2014	In contrast, the concentrations of detergent-soluble and formic acid (FA)-soluble Abeta species increased across all ages examined, thus demonstrating that while amyloid deposition continued, the levels of water-soluble Abeta remained relatively constant.	Water	206-211	amyloid beta (A4) precursor protein	Mus musculus	220-225
24217276-5	2014	Water-soluble cholesterol and Abeta42 dose-dependently increased CD147 protein expression, but reduced FL-AbetaPP protein expression.	Water	0-5	basigin (Ok blood group)	Homo sapiens	65-70
25065822-0	2014	Novel pipette-tip graphene/poly (vinyl alcohol) cryogel composite extractor for the analysis of carbofuran and carbaryl in water.	Water	123-128	TOR signaling pathway regulator	Homo sapiens	14-17
24492378-2	2014	Although 11-FAB is a single-tailed surfactant, pure 11-FAB spontaneously forms vesicles in water.	Water	91-96	FA complementation group B	Homo sapiens	55-58
24387503-3	2014	This paper develops a methodology based on highly sensitive LiF:Mg,Cu,P TLDs to directly estimate the absorbed dose to water in liquid water around a high dose rate (192)Ir brachytherapy source.	Water	119-124	LIF interleukin 6 family cytokine	Homo sapiens	60-63
24387503-3	2014	This paper develops a methodology based on highly sensitive LiF:Mg,Cu,P TLDs to directly estimate the absorbed dose to water in liquid water around a high dose rate (192)Ir brachytherapy source.	Water	135-140	LIF interleukin 6 family cytokine	Homo sapiens	60-63
24387503-5	2014	Measurement strategies and Monte Carlo techniques were developed to calibrate the LiF:Mg,Cu,P detectors in the energy interval characteristic of that found when TLDs are immersed in water around an (192)Ir source.	Water	182-187	LIF interleukin 6 family cytokine	Homo sapiens	82-85
24982958-1	2014	This study aimed to determine the effectiveness of a pregnant mare immunization of a Rhodococcus equi (R. equi) vaccine candidate containing a water-based nanoparticle mineral oil adjuvanted (Montanide IMS 3012) inactive bacterin and virulence-associated protein A (VapA), as well as the administration of anti-R. equi hyperimmune (HI) plasma against R. equi challenge in the mares" foals.	Water	143-148	virulence-associated 15-17 kDa antigen	Rhodococcus equi	234-264
24982958-1	2014	This study aimed to determine the effectiveness of a pregnant mare immunization of a Rhodococcus equi (R. equi) vaccine candidate containing a water-based nanoparticle mineral oil adjuvanted (Montanide IMS 3012) inactive bacterin and virulence-associated protein A (VapA), as well as the administration of anti-R. equi hyperimmune (HI) plasma against R. equi challenge in the mares" foals.	Water	143-148	virulence-associated 15-17 kDa antigen	Rhodococcus equi	266-270
24320821-3	2013	We also explored the patterning of the hydrophilic polymer polyethylene glycol (PEG) and found that, even though PDMS only absorbs trace amounts of water, soaking a PDMS pen array in water enables PEG deposition in completely dry environments for over 2 h. We find that the length of time one can pattern in a dry environment is determined by the availability of absorbed solvent, a relationship that we elucidate by comparing the performance of pens with varying ability to absorb water.	Water	148-153	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	170-173
24320821-3	2013	We also explored the patterning of the hydrophilic polymer polyethylene glycol (PEG) and found that, even though PDMS only absorbs trace amounts of water, soaking a PDMS pen array in water enables PEG deposition in completely dry environments for over 2 h. We find that the length of time one can pattern in a dry environment is determined by the availability of absorbed solvent, a relationship that we elucidate by comparing the performance of pens with varying ability to absorb water.	Water	183-188	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	170-173
24320821-3	2013	We also explored the patterning of the hydrophilic polymer polyethylene glycol (PEG) and found that, even though PDMS only absorbs trace amounts of water, soaking a PDMS pen array in water enables PEG deposition in completely dry environments for over 2 h. We find that the length of time one can pattern in a dry environment is determined by the availability of absorbed solvent, a relationship that we elucidate by comparing the performance of pens with varying ability to absorb water.	Water	183-188	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	170-173
24176881-4	2013	Results from the cognitive behavioral tests revealed early deficits in learning and memory in SAMP8-APP/PS1 mice in the two way active avoidance and Morris water maze tests compared with C57-APP/PS1, SAMP8 wild-type and control mice.	Water	156-161	presenilin 1	Mus musculus	104-107
24316079-5	2013	Similarly to ACBP(-/-) mice, K14-ACBP(-/-) mice exhibit an increased transepidermal water loss, and we show that the hepatic phenotype is caused specifically by the epidermal barrier defect, which leads to increased lipolysis in white adipose tissue.	Water	84-89	keratin 14	Mus musculus	29-32
26592287-3	2013	SPAM is able to provide a qualitative estimate of the thermodynamic profile of bound water molecules that correlates nicely with well-studied structure-activity relationships and observed binding "hot spots".	Water	85-90	eyes shut homolog	Homo sapiens	0-4
23981515-3	2013	To identify these stable substances, the CSE was prepared by passing the main-stream smoke of 10 cigarettes through a Cambridge glass fiber filter, trapping of the smoke in a vessel cooled at -80 C, and subsequent dissolution in 10ml of water.	Water	237-242	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	41-44
24454004-7	2013	In addition, compared with tap water, other drinking water sources during childhood were found to be associated with the elevated risk of intestinal-type gastric cancer, and these associations were slightly stronger among TLR4 rs10983755 A carriers.	Water	53-58	toll like receptor 4	Homo sapiens	222-226
23916954-7	2013	The M-MIP2 showed better selectivity and adsorption behavior with imprinted efficiency higher than (2) in water, as well as in biological fluids.	Water	106-111	C-X-C motif chemokine ligand 2	Homo sapiens	6-10
32261236-5	2013	A large hydration number due to small Gd3+-ion sites and short Gd-O bonds, and thus short Gd-H distances, are the essential structural details pertinent to the high proton relaxivity observed for GNTs suspended in water.	Water	214-219	GRDX	Homo sapiens	38-41
24324370-5	2013	The average 90Sr activity in the bottom water along the offshore profile was 18% lower than that in the surface water and it was caused by an inflow of salt water from the North Sea.	Water	40-45	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	178-181
23062024-11	2013	These studies report enhancement of the in vivo absorption of a poorly water-soluble drug following dispersion with E-SD when compared to formulation in HPMC.	Water	71-76	esterase D	Rattus norvegicus	116-120
24029424-1	2013	Vasopressin regulates water excretion, in part, by controlling the abundances of the water channel aquaporin-2 (AQP2) protein and regulatory proteins in the renal collecting duct.	Water	22-27	aquaporin 2	Mus musculus	112-116
24029424-1	2013	Vasopressin regulates water excretion, in part, by controlling the abundances of the water channel aquaporin-2 (AQP2) protein and regulatory proteins in the renal collecting duct.	Water	85-90	aquaporin 2	Mus musculus	112-116
24077838-1	2013	The conformation and the interaction of CHF2OCF2CHF2 (desflurane II) with one water molecule is investigated theoretically using the ab initio MP2/aug-cc-pvdz and DFT-based M062X/6-311++G(d,p) methods.	Water	78-83	tryptase pseudogene 1	Homo sapiens	143-146
24030886-8	2013	AFA1:1 showed the most rapid dissolution behavior in water; within 10 min, the drug was released completely, while just 60% of acyclovir was dissolved in 1 h.	Water	53-58	AFA1	Homo sapiens	0-4
23727098-4	2013	When beta2-Adrenergic Receptor (beta2AR) was applied as therapeutic gene, PEI/beta2AR treatment significantly attenuated the severity of ALI, including alveolar fluid clearance, lung water content, histopathology, bronchioalveolar lavage cellularity, protein concentration, and inflammatory cytokines in mice with pre-existing ALI.	Water	183-188	adrenergic receptor, beta 2	Mus musculus	5-30
23727098-4	2013	When beta2-Adrenergic Receptor (beta2AR) was applied as therapeutic gene, PEI/beta2AR treatment significantly attenuated the severity of ALI, including alveolar fluid clearance, lung water content, histopathology, bronchioalveolar lavage cellularity, protein concentration, and inflammatory cytokines in mice with pre-existing ALI.	Water	183-188	adrenergic receptor, beta 2	Mus musculus	32-39
23727098-4	2013	When beta2-Adrenergic Receptor (beta2AR) was applied as therapeutic gene, PEI/beta2AR treatment significantly attenuated the severity of ALI, including alveolar fluid clearance, lung water content, histopathology, bronchioalveolar lavage cellularity, protein concentration, and inflammatory cytokines in mice with pre-existing ALI.	Water	183-188	adrenergic receptor, beta 2	Mus musculus	78-85
24070451-0	2013	Combining solvent thermodynamic profiles with functionality maps of the Hsp90 binding site to predict the displacement of water molecules.	Water	122-127	heat shock protein 90 alpha family class A member 1	Homo sapiens	72-77
24070451-6	2013	In this study, we employed IFST to study the displacement of water molecules from the ATP binding site of Hsp90, using a test set of 103 ligands.	Water	61-66	heat shock protein 90 alpha family class A member 1	Homo sapiens	106-111
24012566-4	2013	Furthermore, glucopyranosyl lipid A (GLA) and resiquimod (R848), agonists for TLR4 and TLR7/8 respectively, stimulated cytokine production (IL-12, TNF-alpha, MIP-1beta and IL-10) in bovine dendritic cell cultures, and these were formulated as novel oil-in-water emulsions (GLA-SE and R848-SE) for immunisation studies.	Water	256-261	toll like receptor 4	Bos taurus	78-82
23972471-3	2013	Crystal structures of the GluN1 and GluN3A ligand-binding domains (LBDs) in their apo states unexpectedly reveal open- and closed-cleft conformations, respectively, with water molecules filling the binding pockets.	Water	170-175	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	36-42
23922257-11	2013	Taken together, these results indicate that AQP5 might be an important water channel in astrocytes that is differentially expressed during various brain injuries.	Water	71-76	aquaporin 5	Homo sapiens	44-48
24067081-2	2013	The degree of water transport, via aquaporin2 water channels (AQP2), and sodium transport, via epithelial sodium channels (ENaC) in renal collecting duct principal cells are reflected by the level of urinary excretion of AQP2 (u-AQP2) and the gamma-fraction of ENaC (u-ENaCgamma).	Water	14-19	aquaporin 2	Homo sapiens	62-66
24023878-1	2013	BACKGROUND AND PURPOSE: Aquaporin-4(AQP4) is an abundant water channel protein in brain that regulates water transport to maintain homeostasis.	Water	57-62	aquaporin 4	Rattus norvegicus	24-35
24023878-1	2013	BACKGROUND AND PURPOSE: Aquaporin-4(AQP4) is an abundant water channel protein in brain that regulates water transport to maintain homeostasis.	Water	57-62	aquaporin 4	Rattus norvegicus	36-40
24023878-3	2013	Although, both upregulation and downregulation of AQP4 expression is associated with brain pathology, over expression of AQP4 is one of the chief contributors of water imbalance in brain during ischemic pathology.	Water	162-167	aquaporin 4	Rattus norvegicus	121-125
23694847-8	2013	Duplex-oil films of oxidized mineral oil/mucin (MOx/BSM), human meibum (HM), and bovine meibum (BM) reduce water evaporation by a dissolution-diffusion mechanism, as confirmed by agreement between measurement and theory.	Water	107-112	monooxygenase DBH like 1	Homo sapiens	48-51
23934392-0	2013	Microextraction by packed sorbents combined with surface-enhanced Raman spectroscopy for determination of musk ketone in river water.	Water	127-132	muscle associated receptor tyrosine kinase	Homo sapiens	106-110
23856586-2	2013	Results indicated that the hydrolysis process reduced the inhibition by water in FAME production; in addition, FAME obtained by esterification of hydrolysates was increased by 181.7% compared to FAME obtained by direct transesterification under the same amount of water content (80%).	Water	72-77	benign adult familial myoclonic epilepsy 1	Homo sapiens	81-85
23856586-2	2013	Results indicated that the hydrolysis process reduced the inhibition by water in FAME production; in addition, FAME obtained by esterification of hydrolysates was increased by 181.7% compared to FAME obtained by direct transesterification under the same amount of water content (80%).	Water	72-77	benign adult familial myoclonic epilepsy 1	Homo sapiens	111-115
23856586-2	2013	Results indicated that the hydrolysis process reduced the inhibition by water in FAME production; in addition, FAME obtained by esterification of hydrolysates was increased by 181.7% compared to FAME obtained by direct transesterification under the same amount of water content (80%).	Water	72-77	benign adult familial myoclonic epilepsy 1	Homo sapiens	111-115
23856586-2	2013	Results indicated that the hydrolysis process reduced the inhibition by water in FAME production; in addition, FAME obtained by esterification of hydrolysates was increased by 181.7% compared to FAME obtained by direct transesterification under the same amount of water content (80%).	Water	264-269	benign adult familial myoclonic epilepsy 1	Homo sapiens	81-85
23856586-2	2013	Results indicated that the hydrolysis process reduced the inhibition by water in FAME production; in addition, FAME obtained by esterification of hydrolysates was increased by 181.7% compared to FAME obtained by direct transesterification under the same amount of water content (80%).	Water	264-269	benign adult familial myoclonic epilepsy 1	Homo sapiens	111-115
23856586-2	2013	Results indicated that the hydrolysis process reduced the inhibition by water in FAME production; in addition, FAME obtained by esterification of hydrolysates was increased by 181.7% compared to FAME obtained by direct transesterification under the same amount of water content (80%).	Water	264-269	benign adult familial myoclonic epilepsy 1	Homo sapiens	111-115
23749320-0	2013	Ion-transfer electrochemistry of rat amylin at the water-organogel microinterface array and its selective detection in a protein mixture.	Water	51-56	islet amyloid polypeptide	Rattus norvegicus	37-43
23852332-1	2013	PURPOSE OF REVIEW: Aquaporin-2 (AQP2) water channels in principal cells of the kidney collecting duct are essential for urine concentration.	Water	38-43	aquaporin 2	Homo sapiens	19-30
23852332-1	2013	PURPOSE OF REVIEW: Aquaporin-2 (AQP2) water channels in principal cells of the kidney collecting duct are essential for urine concentration.	Water	38-43	aquaporin 2	Homo sapiens	32-36
26877923-0	2013	Regulation of aquaporin-2 in the kidney: A molecular mechanism of body-water homeostasis.	Water	71-76	aquaporin 2	Homo sapiens	14-25
26877923-2	2013	Aquaporin-2 (AQP2) is the vasopressin-regulated water-channel protein expressed at the connecting tubule and collecting duct, and plays a key role in urine concentration and body-water homeostasis through short-term and long-term regulation of collecting duct water permeability.	Water	48-53	aquaporin 2	Homo sapiens	0-11
26877923-2	2013	Aquaporin-2 (AQP2) is the vasopressin-regulated water-channel protein expressed at the connecting tubule and collecting duct, and plays a key role in urine concentration and body-water homeostasis through short-term and long-term regulation of collecting duct water permeability.	Water	48-53	aquaporin 2	Homo sapiens	13-17
23925294-6	2013	High-yield, water-soluble, and purification-free MucoRice-ARP1 thus forms the basis for orally administered prophylaxis and therapy against rotavirus infections.	Water	12-17	ARP1 actin-related protein 1A, centractin alpha	Mus musculus	58-62
23821666-1	2013	The mineralocorticoid receptor (MR) is a ligand-induced transcription factor belonging to the steroid receptor family and involved in water-electrolyte homeostasis, blood pressure regulation, inflammation and fibrosis in the renocardiovascular system.	Water	134-139	nuclear receptor subfamily 3, group C, member 2	Mus musculus	4-30
23821666-1	2013	The mineralocorticoid receptor (MR) is a ligand-induced transcription factor belonging to the steroid receptor family and involved in water-electrolyte homeostasis, blood pressure regulation, inflammation and fibrosis in the renocardiovascular system.	Water	134-139	nuclear receptor subfamily 3, group C, member 2	Mus musculus	32-34
23889466-7	2013	Dehydration pathways from the neutral S1 and protonated T1 forms lead to stable complexes of HCN and HNC with water but are associated with large energy barriers.	Water	110-115	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	93-96
23698114-5	2013	In contrast, ET-1 increases Na and water excretion through its binding to receptors in the CD.	Water	35-40	endothelin 1	Mus musculus	13-17
23441695-1	2013	Aquaporin-4 (AQP4) is an astroglial water channel protein that plays an important role in the transmembrane movement of water within the central nervous system.	Water	36-41	aquaporin 4	Rattus norvegicus	0-11
23441695-1	2013	Aquaporin-4 (AQP4) is an astroglial water channel protein that plays an important role in the transmembrane movement of water within the central nervous system.	Water	36-41	aquaporin 4	Rattus norvegicus	13-17
23816198-0	2013	Optimization of liquid chromatography-multiple reaction monitoring cubed mass spectrometry assay for protein quantification: application to aquaporin-2 water channel in human urine.	Water	152-157	aquaporin 2	Homo sapiens	140-151
23816198-1	2013	Aquaporin-2 (AQP2) is a water channel protein located in the kidney collecting ducts that has been studied as a potential biomarker of a wide variety of water handling disorders and that could also be used to monitor lesions in the collecting ducts.	Water	24-29	aquaporin 2	Homo sapiens	0-11
23816198-1	2013	Aquaporin-2 (AQP2) is a water channel protein located in the kidney collecting ducts that has been studied as a potential biomarker of a wide variety of water handling disorders and that could also be used to monitor lesions in the collecting ducts.	Water	24-29	aquaporin 2	Homo sapiens	13-17
23721901-11	2013	CONCLUSIONS: While abnormal white matter organization or early cerebellar degeneration could potentially contribute to our findings, the most plausible explanation pertains to abnormalities of CSF drainage in the posterior fossa, with increased extracellular water possibly accounting for this phenomenon.	Water	259-264	colony stimulating factor 2	Homo sapiens	193-196
23907880-3	2013	Ag2 is surrounded by four O atoms from two L2 anions and two water molecules, and two AgI cations in a slightly octahedral coordination geometry.	Water	61-66	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	0-3
23788675-4	2013	Every 1-standard-deviation increase in urinary arsenic (357.9 microg/g creatinine) and well-water arsenic (102.0 microg/L) concentration was related to a 11.7-microm (95% confidence interval (CI): 1.8, 21.6) and 5.1-microm (95% CI: -0.2, 10.3) increase in cIMT, respectively.	Water	92-97	CIMT	Homo sapiens	256-260
23788675-6	2013	Among participants with a higher urinary MMA percentage, a higher ratio of urinary MMA to inorganic arsenic, and a lower ratio of dimethylarsinic acid to MMA, the association between well-water arsenic and cIMT was stronger.	Water	188-193	CIMT	Homo sapiens	206-210
23754513-7	2013	In the EG + 50 % ONB and EG + 100 % ONB groups, ONB water significantly decreased renal CaOx deposits, urinary NAG excretion, and renal monocyte chemoattractant protein-1, osteopontin, and hyaluronic acid expression and increased renal superoxide dismutase-1 expression compared with the EG group.	Water	52-57	C-C motif chemokine ligand 2	Rattus norvegicus	136-170
23901983-1	2013	In this paper we report the geometries and properties of 38 distinct geometrical motifs located on the B3LYP/6-31+G(d), MP2/6-311++G(d, p) potential energy surfaces of the water heptamer.	Water	172-177	tryptase pseudogene 1	Homo sapiens	120-123
23822308-2	2013	By probing the OD stretch mode of HOD in H2O, we observe an extremely rapid decay ( 200 fs) of the population from the second vibrational excited state.	Water	41-44	HOP homeobox	Homo sapiens	34-37
23609128-6	2013	To understand the ionization process of water clusters, DFT- and MP2-based Born-Oppenheimer MD (BOMD) simulations are performed on ionization.	Water	40-45	tryptase pseudogene 1	Homo sapiens	65-68
23861848-5	2013	In mice lacking alpha-syn, we found higher resting values of the apparent diffusion coefficient of water (ADCW) and the extracellular volume fraction (alpha).	Water	99-104	synuclein, alpha	Mus musculus	16-25
23844160-3	2013	ECO combines integral simulation of water and sediment quality with sediment diagenesis and closed mass balances.	Water	36-41	ciliogenesis associated kinase 1	Homo sapiens	0-3
23842380-4	2013	Unfortunately, above-water remote sensing can only determine apparent optical properties leaving the sea surface and is susceptible to near surface environmental conditions for example sky and sunglint.	Water	21-26	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	101-104
23629000-3	2013	Hemin/G-quadruplex DNAenzyme significantly improved the catalysis of H(2)O(2) by oxidation of hydroquinone, resulting in an obvious reduction current of benzoquinone for miRNA-21 indirect detection.	Water	69-74	microRNA 21	Homo sapiens	170-178
23826110-10	2013	Second, after the side chain degradation, the resulting androgen intermediate is activated by adding water to the C-1/C-2 double bond.	Water	101-106	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	114-121
23852264-3	2013	This stimulates cellular signaling processes leading to changes in the phosphorylation of the water channel aquaporin-2 (AQP2).	Water	94-99	aquaporin 2	Rattus norvegicus	121-125
23852264-4	2013	Protein kinase A phoshorylates AQP2 and thereby triggers the translocation of AQP2 from intracellular vesicles into the plasma membrane facilitating water reabsorption from primary urine.	Water	149-154	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	0-16
23852264-4	2013	Protein kinase A phoshorylates AQP2 and thereby triggers the translocation of AQP2 from intracellular vesicles into the plasma membrane facilitating water reabsorption from primary urine.	Water	149-154	aquaporin 2	Rattus norvegicus	31-35
23852264-4	2013	Protein kinase A phoshorylates AQP2 and thereby triggers the translocation of AQP2 from intracellular vesicles into the plasma membrane facilitating water reabsorption from primary urine.	Water	149-154	aquaporin 2	Rattus norvegicus	78-82
23852264-7	2013	The cells are suitable for elucidating molecular mechanisms underlying the control of AQP2 and thus to discover novel drug targets for the treatment of diseases associated with dysregulation of AVP-mediated water reabsorption.	Water	207-212	aquaporin 2	Rattus norvegicus	86-90
23625814-1	2013	A triple junction polymer solar cell in a novel 1 + 2 type configuration provides photoelectrochemical water splitting in its maximum power point at V   1.70 V with an estimated solar to hydrogen energy conversion efficiency of 3.1%.	Water	103-108	nibrin	Homo sapiens	146-154
23641915-1	2013	Iodoacetic acid (IAA) and iodoform (IF) are unregulated iodinated disinfection byproducts (DBPs) found in drinking water.	Water	115-120	protein tyrosine phosphatase, receptor type, N	Mus musculus	17-20
23641915-5	2013	The concentrations of IAA and IF in Shanghai drinking water varied between summer and winter with maximum winter levels of 2.18 mug/L IAA and 0.86 mug/L IF.	Water	54-59	protein tyrosine phosphatase, receptor type, N	Mus musculus	22-32
23641915-5	2013	The concentrations of IAA and IF in Shanghai drinking water varied between summer and winter with maximum winter levels of 2.18 mug/L IAA and 0.86 mug/L IF.	Water	54-59	protein tyrosine phosphatase, receptor type, N	Mus musculus	22-25
23506846-1	2013	Aquaporin 9 (AQP9), an aquaglyceroporin belonging to the AQP water channel family, is permeable not only to water but also to noncharged solutes such as lactate.	Water	61-66	aquaporin 9	Mus musculus	0-11
23506846-1	2013	Aquaporin 9 (AQP9), an aquaglyceroporin belonging to the AQP water channel family, is permeable not only to water but also to noncharged solutes such as lactate.	Water	61-66	aquaporin 9	Mus musculus	13-17
23506846-1	2013	Aquaporin 9 (AQP9), an aquaglyceroporin belonging to the AQP water channel family, is permeable not only to water but also to noncharged solutes such as lactate.	Water	108-113	aquaporin 9	Mus musculus	0-11
23506846-1	2013	Aquaporin 9 (AQP9), an aquaglyceroporin belonging to the AQP water channel family, is permeable not only to water but also to noncharged solutes such as lactate.	Water	108-113	aquaporin 9	Mus musculus	13-17
23848151-11	2013	A sharp increase in JcDHN-2 transcript level occurred in response to water content dropping from 42% in mature seeds to 12% in dry seeds.	Water	69-74	dehydrin Rab18-like	Jatropha curcas	20-27
23614742-5	2013	Hexane- and water-soluble tobacco smoke extracts significantly induced MMP-1 mRNA in both human cultured fibroblasts and keratinocytes in a dose-dependent manner.	Water	12-17	metalloendoproteinase 2-MMP-like	Nicotiana tabacum	71-76
24340577-1	2013	The hygienic analysis of centralized drinking water supply in Tula region has been performed Thepriority contaminants of drinking water have been detected On the basis of risk assessment methodology non-carcinogenic health risks to the child population was calculated.	Water	46-51	ubiquitin associated and SH3 domain containing A	Homo sapiens	62-66
23914530-4	2013	When the original pH of water was 5.0, the concentrations of Cd2+ in samples were 19-58 times higher than the national standard limit, and when the original pH of water were 6.0, 7.0, 8.0 and 9.0, respectively, the concentrations of Cd2+ in samples varied from below to 11 times higher than the national standard limit.	Water	24-29	CD2 molecule	Homo sapiens	61-64
23914530-5	2013	The release of cadmium from the flocs was higher in the disturbed water, with the concentrations of Cd2+ in most samples higher than 5.0 microg x L(-1), and the highest was double of the national standard limit.	Water	66-71	CD2 molecule	Homo sapiens	100-103
23481497-6	2013	In an experimental model, at the initial phase of the disease, the expression of AQP2, the water transport of the collecting duct, is decreased, which explains the higher incidence of nonoliguric AKI.	Water	91-96	aquaporin 2	Homo sapiens	81-85
23637886-4	2013	And H(H2O)m significantly prevented UV-induced MMP-1, COX-2, IL-6 and IL-1beta mRNA expressions in human skin in vivo.	Water	6-9	matrix metallopeptidase 1	Homo sapiens	47-52
23637886-5	2013	We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT cells.	Water	16-19	matrix metallopeptidase 1	Homo sapiens	83-88
23637886-7	2013	In intrinsically aged skin, H(H2O)m application significantly reduced constitutive expressions of MMP-1, IL-6, and IL-1beta mRNA.	Water	30-33	matrix metallopeptidase 1	Homo sapiens	98-103
23637886-8	2013	Additionally, H(H2O)m significantly increased procollagen mRNA and also decreased MMP-1 and IL-6 mRNA expressions in photoaged facial skin.	Water	16-19	matrix metallopeptidase 1	Homo sapiens	82-87
23590853-6	2013	FINDINGS: SAA was soluble in 70% 2-propanol, 8 M urea and Milli-Q water.	Water	66-71	serum amyloid A protein	Equus caballus	10-13
22902409-5	2013	The water formed during esterification process seems to hinder the esters formation, possibly due to competitive adsorption with methanol and to the promotion of the FAME hydrolysis reaction.The observed catalyst deactivation seems to be related to the reduction of vanadium species.	Water	4-9	benign adult familial myoclonic epilepsy 1	Homo sapiens	166-170
23522108-0	2013	Fabrication and application of a new modified electrochemical sensor using nano-silica and a newly synthesized Schiff base for simultaneous determination of Cd2+, Cu2+ and Hg2+ ions in water and some foodstuff samples.	Water	185-190	CD2 molecule	Homo sapiens	157-160
23463988-1	2013	Reversal of the in-water Breslow hydrophobic enhancement of the normal endo-effect on crossing to on-water conditions for Huisgen cycloadditions with increasingly insoluble organic liquid and solid 2pi-dipolarophiles.	Water	19-24	mannosidase endo-alpha	Homo sapiens	71-75
23463988-1	2013	Reversal of the in-water Breslow hydrophobic enhancement of the normal endo-effect on crossing to on-water conditions for Huisgen cycloadditions with increasingly insoluble organic liquid and solid 2pi-dipolarophiles.	Water	101-106	mannosidase endo-alpha	Homo sapiens	71-75
23463988-3	2013	An expected increase of the endo-effect with increasing hydrophobic character of the dipolarophile is overcome by decreasing water solubility causing changeover to on-water conditions.	Water	125-130	mannosidase endo-alpha	Homo sapiens	28-32
23463988-3	2013	An expected increase of the endo-effect with increasing hydrophobic character of the dipolarophile is overcome by decreasing water solubility causing changeover to on-water conditions.	Water	167-172	mannosidase endo-alpha	Homo sapiens	28-32
23380174-1	2013	Montmorillonite K-10 mediated MCR of anilines, arylaldehydes and ethyl-3,3-diethoxypropionate in water afforded 2,6-unsubstituted dihydropyridines depending on the nature of anilines employed.	Water	97-102	keratin 10	Homo sapiens	16-20
23559583-1	2013	In the principal cells of the renal collecting duct, arginine vasopressin (AVP) stimulates the synthesis of cAMP, leading to signaling events that culminate in the phosphorylation of aquaporin-2 water channels and their redistribution from intracellular domains to the plasma membrane via vesicular trafficking.	Water	195-200	aquaporin 2	Homo sapiens	183-194
23559583-2	2013	The molecular mechanisms that control aquaporin-2 trafficking and the consequent water reabsorption, however, are not completely understood.	Water	81-86	aquaporin 2	Homo sapiens	38-49
23614066-3	2013	In particular, AQP3 has two functions: water and glycerol transport.	Water	39-44	aquaporin 3 (Gill blood group)	Rattus norvegicus	15-19
23511424-4	2013	The conversion of a MeOH-H2O mixture proceeds selectively to CO2/H2 gas formation under neutral conditions, thereby allowing the use of the entire hydrogen content (12% by weight).	Water	25-28	complement C2	Homo sapiens	61-67
23359558-4	2013	The AQP11 and AQP12 biological role remains to be fully clarified and their ability to allow transport of water is still debated.	Water	106-111	aquaporin 12A	Homo sapiens	14-19
23461351-8	2013	With the presence of one water molecule, the dehydration pathway leading to HCN is favored.	Water	25-30	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	76-79
23458706-0	2013	Further studies on the role of water in R67 dihydrofolate reductase.	Water	31-36	dihydrofolate reductase	Homo sapiens	44-67
23266764-8	2013	These findings support the use of NLCs approaches for oral delivery of poorly water-soluble P-gp substrates.	Water	78-83	phosphoglycolate phosphatase	Homo sapiens	92-96
23406271-1	2013	We describe the charge transfer interactions between photoexcited CdS nanorods and mononuclear water oxidation catalysts derived from the [Ru(bpy)(tpy)Cl](+) parent structure.	Water	95-100	CDP-diacylglycerol synthase 1	Homo sapiens	66-69
23313152-9	2013	Our results show that AQP5 is a significant component of lens fiber cell membranes, representing the second most abundant water channel in these cells.	Water	122-127	aquaporin 5	Homo sapiens	22-26
23292298-4	2013	Our results showed that             AQP1 expression and myocardial muscle tissue water content increased significantly             6 h after CPB surgery, reaching peak levels 48 h after surgery; additionally,             the protein expression of Cx43 was inversely correlated with AQP1 expression.	Water	81-86	gap junction alpha-1 protein	Capra hircus	247-251
23360616-10	2013	Relative to that of an unmodified duplex, the thermally induced unfolding of the duplexes with centrally positioned Sp-R and Sp-S lesions into single strands is accompanied by a smaller release of cationic counterions (Deltan(Na+) = 0.6 mol of Na+/mol of duplex) and water molecules (Deltan(w) = 17 mol of H2O/mol of duplex).	Water	267-272	spontaneous seizure	Mus musculus	125-129
23360616-10	2013	Relative to that of an unmodified duplex, the thermally induced unfolding of the duplexes with centrally positioned Sp-R and Sp-S lesions into single strands is accompanied by a smaller release of cationic counterions (Deltan(Na+) = 0.6 mol of Na+/mol of duplex) and water molecules (Deltan(w) = 17 mol of H2O/mol of duplex).	Water	306-309	spontaneous seizure	Mus musculus	125-129
23205949-4	2013	Deprotection of the acetate protecting groups from the hyperbranched mannose polymers yields water-soluble polymers that interact with mannose binding lectin (MBL), a key protein of the innate immunity complement system.	Water	93-98	mannose binding lectin 2	Homo sapiens	135-157
23205949-4	2013	Deprotection of the acetate protecting groups from the hyperbranched mannose polymers yields water-soluble polymers that interact with mannose binding lectin (MBL), a key protein of the innate immunity complement system.	Water	93-98	mannose binding lectin 2	Homo sapiens	159-162
23311644-8	2013	Using detailed ab initio calculations at the MP2 level, our study attempts to predict the possible structures, energies, and thermochemical parameters of corresponding MTBE-water molecular complexes in more detail.	Water	173-178	tryptase pseudogene 1	Homo sapiens	45-48
22460590-2	2013	Changing of the substrate structure, water content, solvent, and temperature was found to have profound influences on the lipase performance.	Water	37-42	PAN0_003d1715	Moesziomyces antarcticus	122-128
23179381-7	2013	In behavioral analysis, NOD/SCID.E2f1(-/-) mice drank plenty of water when they ate dry food, and the frequency and time of water intake were almost double compared with control NOD/SCID mice.	Water	64-69	E2F transcription factor 1	Mus musculus	33-37
23179381-7	2013	In behavioral analysis, NOD/SCID.E2f1(-/-) mice drank plenty of water when they ate dry food, and the frequency and time of water intake were almost double compared with control NOD/SCID mice.	Water	124-129	E2F transcription factor 1	Mus musculus	33-37
23164217-0	2013	Source water quality shaping different fouling scenarios in a full-scale desalination plant at the Red Sea.	Water	7-12	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	103-106
23142267-1	2013	Aquaporin-4 (AQP-4) is the principal brain water channel and is predominantly expressed in astrocytes suggesting its dynamic involvement in water homeostasis in brain tissue.	Water	43-48	aquaporin 4	Rattus norvegicus	0-11
23142267-1	2013	Aquaporin-4 (AQP-4) is the principal brain water channel and is predominantly expressed in astrocytes suggesting its dynamic involvement in water homeostasis in brain tissue.	Water	43-48	aquaporin 4	Rattus norvegicus	13-18
23142267-1	2013	Aquaporin-4 (AQP-4) is the principal brain water channel and is predominantly expressed in astrocytes suggesting its dynamic involvement in water homeostasis in brain tissue.	Water	140-145	aquaporin 4	Rattus norvegicus	0-11
23142267-1	2013	Aquaporin-4 (AQP-4) is the principal brain water channel and is predominantly expressed in astrocytes suggesting its dynamic involvement in water homeostasis in brain tissue.	Water	140-145	aquaporin 4	Rattus norvegicus	13-18
22983217-5	2013	injection or micro-osmotic pump to Nf1(+/-) mice significantly improved performance on the water maze task in comparison to saline treated Nf1(+/-) mice on the third day of training and on the corresponding probe test.	Water	91-96	neurofibromin 1	Mus musculus	35-38
23015545-1	2013	The aquaporin-2 (AQP2) water channel relocates mainly to the apical plasma membrane of collecting duct principal cells after vasopressin (VP) stimulation.	Water	23-28	aquaporin 2	Canis lupus familiaris	4-15
23015545-1	2013	The aquaporin-2 (AQP2) water channel relocates mainly to the apical plasma membrane of collecting duct principal cells after vasopressin (VP) stimulation.	Water	23-28	aquaporin 2	Canis lupus familiaris	17-21
24025569-0	2013	Tip-enhanced Raman spectroscopy of lipid bilayers in water with an alumina- and silver-coated tungsten tip.	Water	53-58	TOR signaling pathway regulator	Homo sapiens	0-3
23423544-0	2013	Insight towards the conserved water mediated recognition of catalytic and structural Zn(+2) ions in human Matrix Metalloproteinase-8 enzyme: A study by MD-simulation methods.	Water	30-35	matrix metallopeptidase 8	Homo sapiens	106-132
23423544-2	2013	Extensive MD-simulation of the PDB and solvated structures of hMMP-8 has revealed the presence of few conserved water molecules around the catalytic and structural zinc (ZnC and ZnS) ions.	Water	112-117	matrix metallopeptidase 8	Homo sapiens	62-68
23769335-0	2013	Isolation By Distance (IBD) signals in the deep-water rose shrimp Parapenaeus longirostris (Lucas, 1846) (Decapoda, Panaeidae) in the Mediterranean Sea.	Water	48-53	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	148-151
32696649-4	2020	To do so, we benchmark a recent correction for the SCC-DFTB atomic charges which allows for a drastic improvement of the pair radial distribution functions of liquid water as compared to both experimental data and density functional theory results performed in the generalized-gradient approximation.	Water	166-171	serpin family B member 3	Homo sapiens	51-54
32696649-6	2020	This allows us to rationalize the impact of nuclear quantum effects on the SCC-DFTB description of liquid water.	Water	106-111	serpin family B member 3	Homo sapiens	75-78
23176748-6	2013	A 2009 experiment showed that AQP5 facilitates not only permeation of water but also permeation of hydrophobic gas molecules across the cell membrane.	Water	70-75	aquaporin 5	Homo sapiens	30-34
32696649-7	2020	This study evidences the rather good ability of SCC-DFTB to describe liquid water and liquid benzene.	Water	76-81	serpin family B member 3	Homo sapiens	48-51
32851539-1	2021	In astrocytes, the water-permeable channel aquaporin-4 (AQP4) is concentrated at the endfeet that abut the blood vessels of the brain.	Water	19-24	aquaporin 4	Rattus norvegicus	43-54
23117861-2	2013	For this purpose, we estimate both of the two values in water column over 12-h tidal cycles of the Jade Bay, southern North Sea.	Water	56-61	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	124-127
32851539-1	2021	In astrocytes, the water-permeable channel aquaporin-4 (AQP4) is concentrated at the endfeet that abut the blood vessels of the brain.	Water	19-24	aquaporin 4	Rattus norvegicus	56-60
32673289-5	2020	Moreover, single nucleus RNA sequencing determined that epithelial HDAC1 and HDAC2 are necessary for expression of many sodium or water transporters and channels.	Water	130-135	histone deacetylase 1	Mus musculus	67-72
24429828-2	2013	GN and UGN (guanylin peptides) induce secretion of electrolytes and water in both intestine and kidney.	Water	68-73	guanylate cyclase activator 2A	Homo sapiens	0-2
24429828-2	2013	GN and UGN (guanylin peptides) induce secretion of electrolytes and water in both intestine and kidney.	Water	68-73	guanylate cyclase activator 2A	Homo sapiens	12-20
32691025-1	2020	A new paramagnetic heteronuclear complex formulated as [K3Fe(mu-ox)3(H2O)3]n (1), where ox2- is oxalate, has been synthesized under hydrothermal condition.	Water	69-72	CD200 molecule	Homo sapiens	88-91
22966789-9	2013	The increases in water and sodium absorption via AQP2 and ENaC after furosemide most likely are compensatory phenomena to antagonize water and sodium depletion.	Water	17-22	aquaporin 2	Homo sapiens	49-53
22966789-9	2013	The increases in water and sodium absorption via AQP2 and ENaC after furosemide most likely are compensatory phenomena to antagonize water and sodium depletion.	Water	133-138	aquaporin 2	Homo sapiens	49-53
32780743-0	2020	Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila.	Water	45-50	Cyclic-AMP response element binding protein B	Drosophila melanogaster	29-34
23160444-8	2013	SUMMARY: In the collecting duct, the ET1/nitric oxide pathways are intimately linked, and deletion of collecting duct ET1, ETB receptor or NOS1beta results in a salt-sensitive phenotype, which is at least partially dependent on dysregulation of sodium and water reabsorption.	Water	256-261	endothelin 1	Mus musculus	118-121
23160444-8	2013	SUMMARY: In the collecting duct, the ET1/nitric oxide pathways are intimately linked, and deletion of collecting duct ET1, ETB receptor or NOS1beta results in a salt-sensitive phenotype, which is at least partially dependent on dysregulation of sodium and water reabsorption.	Water	256-261	endothelin receptor type B	Mus musculus	123-126
32772893-13	2021	This is because water is more inclined to provide desirable interacting with myoglobin functional groups as compared to glucose.	Water	16-21	myoglobin	Homo sapiens	77-86
23843873-4	2013	We also found that pretreatment of fibroblasts with Neonauclea reticulata water extract resulted in markedly lower levels of MMP-1, -3, and -9 expressions.	Water	74-79	matrix metallopeptidase 1	Homo sapiens	125-142
32764312-0	2020	Water-Resistant Casein-Based Adhesives for Veneer Bonding in Biodegradable Ski Cores.	Water	0-5	SKI proto-oncogene	Homo sapiens	75-78
24069046-6	2013	Deep sea water-treated BMSCs showed stronger osteogenic differentiation such as BMP2, RUNX2, OPN, and OCN, and enhanced colony forming abilities, compared to the control group.	Water	9-14	runt related transcription factor 2	Mus musculus	86-91
32740916-12	2020	Children who had a mutation of that filaggrin gene and who were exposed to harder water, had about a threefold increased risk of developing eczema than those without the mutation and who were exposed to softer water.	Water	82-87	filaggrin	Homo sapiens	36-45
22918668-2	2013	CYP1A1 is phase I enzyme that converts carcinogens into water soluble compounds which are easily excreted from body.	Water	56-61	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
32740916-12	2020	Children who had a mutation of that filaggrin gene and who were exposed to harder water, had about a threefold increased risk of developing eczema than those without the mutation and who were exposed to softer water.	Water	210-215	filaggrin	Homo sapiens	36-45
32740916-13	2020	The researchers conclude therefore that in children there seems to be a link between having a filaggrin mutation, being exposed to harder water and developing eczema.	Water	138-143	filaggrin	Homo sapiens	94-103
23520529-0	2013	AQP4-dependent water transport plays a functional role in exercise-induced skeletal muscle adaptations.	Water	15-20	aquaporin 4	Rattus norvegicus	0-4
32580146-3	2020	For a geneticist, hereditary NDI is a rare disease with a prevalence of five per million males secondary to loss of function of the vasopressin V2 receptor, an X-linked gene, or loss of function of the water channel AQP2.	Water	202-207	aquaporin 2	Homo sapiens	216-220
23995803-7	2013	Meanwhile, bisacodyl, which is classified as a stimulant laxative, decreases the expression level of AQP3 in the mucosal epithelial cells of the colon, resulting in the inhibition of water transfer from the intestinal tract to the vascular side of the epithelium, eventually leading to the development of diarrhea.	Water	183-188	aquaporin 3 (Gill blood group)	Homo sapiens	101-105
32507602-2	2020	METHODS: FCHO1560-571, a synthetic water-soluble peptide, was generated from the PKB substrate motif 560PPRRLRSRKVSC571 found in the human FCHO1 protein.	Water	35-40	FCH and mu domain containing endocytic adaptor 1	Homo sapiens	9-14
23172351-5	2012	The results of the water maze test indicated that Tg-APP/PS1 mice which had been injected with Lenti-GFP showed an increased latency in finding the hidden-platform and markedly enhanced navigation near the maze-wall, and that such behavioral deficits were significantly reversed in Tg-APP/PS1 mice injected with Lenti-NIa.	Water	19-24	presenilin 1	Mus musculus	57-60
32661144-8	2020	In the second growing season of treatment, the shrub warming response rate increased to 2.54 km m-2  C-1 Soil moisture was negatively correlated with fine-root growth, highlighting that drying of these typically water-saturated ecosystems can fuel a surprising burst in shrub belowground productivity, one possible mechanism explaining the "shrubification" of northern peatlands in response to global change.	Water	212-217	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	101-104
23227925-8	2012	Antioxidant (EUK-8) and p38 MAPK inhibitor (SB202190) treatment attenuated the increase in caspase-3 activity, cell death and WDR35 expression induced by bupivacaine or H(2)O(2).	Water	169-174	WD repeat domain 35	Mus musculus	126-131
32731324-6	2020	Pure water and organic solvent fluxes generally followed the trend NF270 > NF90 > BW30 > XLE, with the solvent choice playing a major role in the separation process.	Water	5-10	interleukin enhancer binding factor 3	Homo sapiens	75-79
32529832-5	2020	Likewise, drinking water exposures of lacZ transgenic mice to 0, 100, 500, or 750 ppm ACN for 4 weeks caused significant dose-dependent elevations in Hprt mutant frequencies in splenic T-cells; however, these ACN exposures did not increase the frequency of lacZ transgene mutations above spontaneous background levels in several tissue from the same animals.	Water	19-24	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	150-154
23054991-1	2012	Cocrystals of itraconazole, an antifungal drug with poor bioavailability, and succinic acid, a water-soluble dicarboxylic acid, were formed by gas antisolvent (GAS) cocrystallization using pressurized CO(2) to improve itraconazole dissolution.	Water	95-100	gastrin	Homo sapiens	143-146
23054991-1	2012	Cocrystals of itraconazole, an antifungal drug with poor bioavailability, and succinic acid, a water-soluble dicarboxylic acid, were formed by gas antisolvent (GAS) cocrystallization using pressurized CO(2) to improve itraconazole dissolution.	Water	95-100	gastrin	Homo sapiens	160-163
23706747-0	2013	Nitric oxide and AQP2 in hypothyroid rats: a link between aging and water homeostasis.	Water	68-73	aquaporin 2	Rattus norvegicus	17-21
32923594-4	2020	This local, geometry-driven effect, namely, tip-induced flipping of droplets, is found to be generic and have spectacular global consequences: Vast assemblies of Janus pillars enable a continuous, long-range, and fast self-transport of water harvested from fogs, which makes it possible to collect and concentrate droplets at different scales.	Water	236-241	TOR signaling pathway regulator	Homo sapiens	44-47
23763299-0	2013	Benchmark study of the interaction energy for an (H2O)16 cluster: quantum Monte Carlo and complete basis set limit MP2 results.	Water	50-53	tryptase pseudogene 1	Homo sapiens	115-118
23042941-5	2012	We hypothesized that the water, glycerol, and urea channel aquaporin-9 (AQP9) is involved in hepatocyte urea release.	Water	25-30	aquaporin 9	Mus musculus	59-70
23042941-5	2012	We hypothesized that the water, glycerol, and urea channel aquaporin-9 (AQP9) is involved in hepatocyte urea release.	Water	25-30	aquaporin 9	Mus musculus	72-76
32222061-0	2020	Simple 2D/0D CoP Integration in a Metal-Organic Framework-derived Bifunctional Electrocatalyst for Efficient Overall Water Splitting.	Water	117-122	caspase recruitment domain family member 16	Homo sapiens	13-16
22964219-0	2012	Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity.	Water	107-112	caspase 8	Mus musculus	13-22
22964219-10	2012	Altogether our data suggest that water-soluble ruthenium(II)-derived compounds represent an interesting class of molecules that, depending on their structures, can target several pro-apoptotic signaling pathways leading to reactive oxygen species production and caspase 8 activation.	Water	33-38	caspase 8	Mus musculus	262-271
23783808-1	2013	A new water-soluble inclusion complex of ilexgenin A (IGA) with beta-cyclodextrin polymer (CDP) was prepared by a facile strategy and characterized by (1)H NMR , FT-IR, and UV-vis spectroscopy.	Water	6-11	cut-like homeobox 1	Mus musculus	64-95
23728221-0	2013	Branched TiO2 nanoarrays sensitized with CdS quantum dots for highly efficient photoelectrochemical water splitting.	Water	100-105	CDP-diacylglycerol synthase 1	Homo sapiens	41-44
32222061-5	2020	Thus, CoP/HNCNP@2D CoP exhibited outstanding OER and HER activity and a low cell voltage when being employed as both the anode and cathode in a two-electrode water electrolyzer.	Water	158-163	caspase recruitment domain family member 16	Homo sapiens	6-9
22949628-6	2012	CYP1A1, in contrast to CYP1A2, displayed much higher uncoupling, producing more water.	Water	80-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
32635272-1	2020	Water-soluble pteroyl-closo-dodecaborate conjugates (PBCs 1-4), were developed as folate receptor (FRalpha) targeting boron carriers for boron neutron capture therapy (BNCT).	Water	0-5	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	99-106
23226759-5	2012	The water content was lower in the EPO group at each time point compared to the control group.	Water	4-9	erythropoietin	Rattus norvegicus	35-38
32296905-9	2020	Surface water analysis resulted in average percent recoveries of 109% for Cd2+, 93% for As3+, and 92% for Se4+, indicating the proposed method is accurate and reliable for the simultaneous detection of Cd2+, As3+, and Se4+ in real water samples.	Water	8-13	CD2 molecule	Homo sapiens	74-77
22786728-6	2012	This decrease in the RVD activity did not correlate with changes in AQP2 function or expression, demonstrating that AQP2-besides increasing water permeability-would play some other role.	Water	140-145	aquaporin 2	Homo sapiens	116-120
23672418-1	2013	Aquaporin (AQP) 1 and AQP 4 are members of the aquaporin water channel family that play an important role in reabsorption of water from the renal tubular fluid to concentrate urine.	Water	57-62	aquaporin 4	Bos taurus	22-27
23672418-1	2013	Aquaporin (AQP) 1 and AQP 4 are members of the aquaporin water channel family that play an important role in reabsorption of water from the renal tubular fluid to concentrate urine.	Water	125-130	aquaporin 4	Bos taurus	22-27
23672418-6	2013	We concluded that AQP 1 and AQP 4 in the bovine kidney showed some differences from other species in renal trans-epithelial water transport.	Water	124-129	aquaporin 4	Bos taurus	28-33
32296905-9	2020	Surface water analysis resulted in average percent recoveries of 109% for Cd2+, 93% for As3+, and 92% for Se4+, indicating the proposed method is accurate and reliable for the simultaneous detection of Cd2+, As3+, and Se4+ in real water samples.	Water	8-13	CD2 molecule	Homo sapiens	202-205
32296905-9	2020	Surface water analysis resulted in average percent recoveries of 109% for Cd2+, 93% for As3+, and 92% for Se4+, indicating the proposed method is accurate and reliable for the simultaneous detection of Cd2+, As3+, and Se4+ in real water samples.	Water	231-236	CD2 molecule	Homo sapiens	202-205
22836670-3	2012	One NPP candidate is aquaporin 9 (AQP9), a glycerol-permeable water channel expressed in erythrocytes.	Water	62-67	aquaporin 9	Mus musculus	21-32
32487560-6	2020	Water-loaded endothelin A receptor knockout mice, compared with control mice, had markedly enhanced urine volume and reduced urine osmolality associated with increased urinary endothelin-1 and PGE2 excretion, increased cyclooxygenase-2 protein expression, and decreased inner medullary aquaporin-2 protein content.	Water	0-5	endothelin 1	Mus musculus	176-188
22836670-3	2012	One NPP candidate is aquaporin 9 (AQP9), a glycerol-permeable water channel expressed in erythrocytes.	Water	62-67	aquaporin 9	Mus musculus	34-38
23427027-6	2013	Increased ELP content in the scaffolds appears to have reduced the residual water content based on Fourier transformed infrared spectroscopy and differential scanning calorimetry.	Water	76-81	nuclear receptor subfamily 5 group A member 1	Homo sapiens	10-13
23033059-3	2012	Photodegradation of the self-assembled system occurs at the ligand framework of CoP, which can be readily repaired by addition of fresh ligand, resulting in turnover numbers above 300 mol H(2) (mol CoP)(-1) and above 200,000 mol H(2) (mol TiO(2) nanoparticles)(-1) in water.	Water	268-273	caspase recruitment domain family member 16	Homo sapiens	80-83
32487560-6	2020	Water-loaded endothelin A receptor knockout mice, compared with control mice, had markedly enhanced urine volume and reduced urine osmolality associated with increased urinary endothelin-1 and PGE2 excretion, increased cyclooxygenase-2 protein expression, and decreased inner medullary aquaporin-2 protein content.	Water	0-5	aquaporin 2	Mus musculus	286-297
23837574-3	2013	However, professional speed skaters also inhale nebulized isotonic saline or tap water before and after a race or intense training.	Water	81-86	filamin B	Homo sapiens	77-80
23837574-4	2013	The use of nebulized isotonic saline or tap water to prevent EIB has not been studied before, raising questions about safety and efficacy.	Water	44-49	filamin B	Homo sapiens	40-43
32500261-10	2020	The surface activity of the product was also investigated and it was found it can adsorb Pb2+ and Cd2+ from the water with 100% efficiency.	Water	112-117	CD2 molecule	Homo sapiens	98-101
32481831-3	2013	This one-step chemical modification of high-molecular-weight chitosan (approximately 100 kDa) dramatically increased the water solubility of the chitosan derivative to 60 mg mL-1 at pH 7.0.	Water	121-126	L1 cell adhesion molecule	Mus musculus	174-178
23844160-0	2013	ECO: a generic eutrophication model including comprehensive sediment-water interaction.	Water	69-74	ciliogenesis associated kinase 1	Homo sapiens	0-3
22895529-5	2012	The applicability of the set up to study biological transport reactions was demonstrated by examining the osmotic water permeability of human aquaporin (AQP5) reconstituted in proteoliposomes.	Water	114-119	aquaporin 5	Homo sapiens	153-157
23844160-1	2013	The content and calibration of the comprehensive generic 3D eutrophication model ECO for water and sediment quality is presented.	Water	89-94	ciliogenesis associated kinase 1	Homo sapiens	81-84
32930176-7	2020	These results demonstrated that graphene was a promising material as the ion-to-electron transducer layer in the development of ASC-ISEs for sulfide detection, and the results of practical applications in tap water and seawater samples showed that the ASC-ISEs held significant promise in a broad range of applications.	Water	209-214	steroid sulfatase	Homo sapiens	252-255
23844160-2	2013	Based on a computational grid for water and sediment, ECO is used as a tool for water quality management to simulate concentrations and mass fluxes of nutrients (N, P, Si), phytoplankton species, detrital organic matter, electron acceptors and related substances.	Water	34-39	ciliogenesis associated kinase 1	Homo sapiens	54-57
25337093-4	2012	Silencing C/EBP homologous protein gene expression significantly reduced cerebral infarction volume, decreased water content and tumor necrosis factor-alpha and interleukin-1beta mRNA expression in brain tissues following infarction, diminished the number of TUNEL-positive cells in the infarct region, decreased caspase-3 protein content and increased Bcl-2 protein content.	Water	111-116	DNA-damage inducible transcript 3	Rattus norvegicus	10-34
32575072-4	2020	CCL20-neutralizing antibody alleviated SAH-induced neurological deficits, decreased brain water content and neuronal apoptosis, and repressed microglial activation.	Water	90-95	chemokine (C-C motif) ligand 20	Mus musculus	0-5
23232191-0	2012	Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells.	Water	4-9	thymic stromal lymphopoietin	Homo sapiens	55-83
23535719-5	2013	Spatial deficits in PLB1Triple mice were confirmed at 12, but not 4 months in both water maze tasks.	Water	83-88	phospholipase B1	Mus musculus	20-30
32452684-3	2020	The near-zero coverage hydration enthalpy on Cu-MOR is -133.1+-6.0 kJ/mol water, which is relevant to Cu-MOR regeneration water as oxidant.	Water	74-79	opioid receptor mu 1	Homo sapiens	48-51
22841706-5	2012	The nanomechanical mapping also demonstrated some swelling of the layer in water and pointed toward an important contribution of electrostatic interactions for the tip-surface adhesion.	Water	75-80	TOR signaling pathway regulator	Homo sapiens	164-167
32452684-3	2020	The near-zero coverage hydration enthalpy on Cu-MOR is -133.1+-6.0 kJ/mol water, which is relevant to Cu-MOR regeneration water as oxidant.	Water	74-79	opioid receptor mu 1	Homo sapiens	105-108
32452684-3	2020	The near-zero coverage hydration enthalpy on Cu-MOR is -133.1+-6.0 kJ/mol water, which is relevant to Cu-MOR regeneration water as oxidant.	Water	122-127	opioid receptor mu 1	Homo sapiens	48-51
23558339-1	2013	The epithelial sodium channel (ENaC) is one of the central effectors involved in regulation of salt and water homeostasis in the kidney.	Water	104-109	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	31-35
22903598-3	2012	Then, hDMP1 was coated onto the surface of Ti substrates via a biochemical technique and the procedure was divided into three steps: in the beginning, titanium was treated by regular polishing and denoted as Cp-Ti; then, Cp-Ti received alkaline and water treatment and was nominated as AW-Ti; finally, AW-Ti was coated with hDMP1 and referred to as hDMP1-Ti.	Water	249-254	dentin matrix acidic phosphoprotein 1	Homo sapiens	6-11
32452684-3	2020	The near-zero coverage hydration enthalpy on Cu-MOR is -133.1+-6.0 kJ/mol water, which is relevant to Cu-MOR regeneration water as oxidant.	Water	122-127	opioid receptor mu 1	Homo sapiens	105-108
32453572-9	2020	Complexation with HCN remains endothermic in water, although less so and the exothermicity of pnicogen bond formation with pyridine is enhanced by solvation.	Water	45-50	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	18-21
32193123-6	2020	The highly active n-Al/CaO interacted with water as the hydrogen donor to promote the reductive dechlorination process.	Water	43-48	mummy	Drosophila melanogaster	23-26
22932892-3	2012	Here we show that hepatoma cells and primary hepatocytes strongly up-regulate hepcidin when exposed to low concentrations of H(2)O(2) (0.3-6 muM), concentrations that are comparable with levels of H(2)O(2) released by inflammatory cells.	Water	125-130	hepcidin antimicrobial peptide	Homo sapiens	78-86
22932892-3	2012	Here we show that hepatoma cells and primary hepatocytes strongly up-regulate hepcidin when exposed to low concentrations of H(2)O(2) (0.3-6 muM), concentrations that are comparable with levels of H(2)O(2) released by inflammatory cells.	Water	197-202	hepcidin antimicrobial peptide	Homo sapiens	78-86
22932892-9	2012	Our results suggest a novel mechanism of hepcidin regulation by nanomolar levels of sustained H(2)O(2).	Water	94-99	hepcidin antimicrobial peptide	Homo sapiens	41-49
24152854-0	2013	Thermal water of Vetriolo, Trentino, inhibits the negative effect of interleukin-1&amp;#946; on nitric oxide production and apoptosis in human osteoarthritic chondrocyte.	Water	8-13	interleukin 1 alpha	Homo sapiens	69-82
23624112-8	2013	Thus, the increased Lp(c) and transcription levels of TaPIP1;2 and TaPIP2;5 in wheat roots provides insight into the mechanisms underlying enhanced root water uptake with increasing chromosome ploidy during wheat evolution.	Water	153-158	aquaporin PIP1-3/PIP1-4	Triticum aestivum	54-62
32437172-4	2020	Herein, we provide the synthesis and structural characterization of six model coordination compounds that contain acetamidoxime/benzamidoxime (AAO/BAO) coordinated to the uranyl cation: [UO2(eta1-AAO)(NO3)2(H2O)] (1), [UO2(eta1-AAO)2(NO3)2] (2), [UO2(eta2-BAO)2(CH3OH)2] (3), [(UO2)3(eta2-BAO)3(mu2-NO3)3] (4), [(UO2)4(mu3-O)2(mu2-BAO)4(eta1-BAO)4(H2O)2](NO3)4 (5), and [(UO2)4(mu3-O)2(mu2-BAO)4(eta1-BAO)6Na(NO3)2](NO3)3 (6).	Water	207-210	secreted phosphoprotein 1	Homo sapiens	191-195
23541697-3	2013	Here, we establish a convenient method to synthesize large amounts of functional human aquaglyceroporin 3 protein (AQP3), an AQP of physiological relevance conducting glycerol and some small neutral solutes besides water.	Water	215-220	aquaporin 3 (Gill blood group)	Homo sapiens	87-113
23541697-3	2013	Here, we establish a convenient method to synthesize large amounts of functional human aquaglyceroporin 3 protein (AQP3), an AQP of physiological relevance conducting glycerol and some small neutral solutes besides water.	Water	215-220	aquaporin 3 (Gill blood group)	Homo sapiens	115-119
22973883-10	2012	This is majorly caused by the protonation of the protein, which was further verified by the dissolution of zein in water (a nonsolvent for zein) with the addition of acids.	Water	115-120	zein	Zea mays	107-111
22973883-10	2012	This is majorly caused by the protonation of the protein, which was further verified by the dissolution of zein in water (a nonsolvent for zein) with the addition of acids.	Water	115-120	zein	Zea mays	139-143
23541697-7	2013	Functionality of hAQP3-6His was further confirmed by the strong inhibition of the glycerol and water permeability by phloretin and HgCl2, respectively, two blockers of AQP3.	Water	95-100	aquaporin 3 (Gill blood group)	Homo sapiens	17-24
32437172-4	2020	Herein, we provide the synthesis and structural characterization of six model coordination compounds that contain acetamidoxime/benzamidoxime (AAO/BAO) coordinated to the uranyl cation: [UO2(eta1-AAO)(NO3)2(H2O)] (1), [UO2(eta1-AAO)2(NO3)2] (2), [UO2(eta2-BAO)2(CH3OH)2] (3), [(UO2)3(eta2-BAO)3(mu2-NO3)3] (4), [(UO2)4(mu3-O)2(mu2-BAO)4(eta1-BAO)4(H2O)2](NO3)4 (5), and [(UO2)4(mu3-O)2(mu2-BAO)4(eta1-BAO)6Na(NO3)2](NO3)3 (6).	Water	348-351	secreted phosphoprotein 1	Homo sapiens	191-195
23541697-7	2013	Functionality of hAQP3-6His was further confirmed by the strong inhibition of the glycerol and water permeability by phloretin and HgCl2, respectively, two blockers of AQP3.	Water	95-100	aquaporin 3 (Gill blood group)	Homo sapiens	18-22
22802001-0	2012	Co-localisation of K(ir)4.1 and AQP4 in rat and human cochleae reveals a gap in water channel expression at the transduction sites of endocochlear K(+) recycling routes.	Water	80-85	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	19-27
22802001-0	2012	Co-localisation of K(ir)4.1 and AQP4 in rat and human cochleae reveals a gap in water channel expression at the transduction sites of endocochlear K(+) recycling routes.	Water	80-85	aquaporin 4	Rattus norvegicus	32-36
22802001-5	2012	This study describes the subcellular co-localisation of the K(ir)4.1 K(+) channel (K(ir)4.1) and the aquaporin-4 water channel (AQP4) in SCs, on the basis of immunohistochemical double-labelling experiments in rat and human cochleae.	Water	113-118	aquaporin 4	Rattus norvegicus	128-132
32463675-0	2020	CoP Microscale Prism-like Superstructure Arrays on Ni Foam as an Efficient Bifunctional Electrocatalyst for Overall Water Splitting.	Water	116-121	caspase recruitment domain family member 16	Homo sapiens	0-3
22896687-3	2012	In this report, we show that PfCelTOS vaccines containing GLA-SE (a stable oil-in-water emulsion combined with a Toll-like receptor 4 [TLR4] agonist) elicit strong Th1-type immune responses in BALB/c mice.	Water	82-87	galactosidase, alpha	Mus musculus	58-61
23551166-7	2013	In the case of brinicles, on the other hand, in floating sea ice we have porous ice in a mushy layer that filters out water, by freezing it, and allows concentrated brine through.	Water	118-123	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	57-60
23683400-7	2013	LOQs ranged from 0.008 to 1.54 ng/L for surface river water and from 0.178/0.364 to 12.5/25.0 ng/L (except for alkylphenol monoethoxylates) for effluent/influent waste water.	Water	54-59	TARBP2 subunit of RISC loading complex	Homo sapiens	0-4
23683400-7	2013	LOQs ranged from 0.008 to 1.54 ng/L for surface river water and from 0.178/0.364 to 12.5/25.0 ng/L (except for alkylphenol monoethoxylates) for effluent/influent waste water.	Water	168-173	TARBP2 subunit of RISC loading complex	Homo sapiens	0-4
23043066-1	2012	Ceruloplasmin, a multi-copper oxidase with four active copper atoms, oxidizes Fe2+ to Fe3+ and concomittantly fully reduces oxygen to water.	Water	134-139	ceruloplasmin	Homo sapiens	0-13
32463675-5	2020	Finally, CoP arrays were produced through phosphatization of the prepared Co-based array precursor, using NaH2PO2 H2O as the P source.	Water	114-117	caspase recruitment domain family member 16	Homo sapiens	9-12
32463675-6	2020	The fabricated CoP/SPNF electrocatalyst exhibits impressive bifunctional performance for the hydrogen evolution reaction (HER, overpotential of 45 mV at 10 mA cm-2) and oxygen evolution reaction (OER, overpotential of 215 mV at 80 mA cm-2) and consequently enables efficient electrolytic water splitting with a low cell voltage of 1.547 V at 30 mA cm-2 and a prominent durability.	Water	288-293	caspase recruitment domain family member 16	Homo sapiens	15-18
32502924-4	2020	The distributions range from 1 % to 135 % of the CSDA range in water and from 1 % to 186 % in tantalum.	Water	63-68	Y-box binding protein 3	Homo sapiens	49-53
22252122-4	2012	AQP6 and AQP11 are localized within the cell, with AQP6 involved in anion transport and AQP11 water transport.	Water	94-99	aquaporin 6	Homo sapiens	0-4
32267715-5	2020	Accumulating evidence in the literature indicates that the water-, glycerol-, and hydrogen peroxide-transporting channel aquaporin-3 (AQP3) plays a key role in various processes involved in keratinocyte function, and abnormalities in this channel have been observed in several human skin diseases.	Water	59-64	aquaporin 3 (Gill blood group)	Homo sapiens	121-132
22425521-3	2012	AQP3, 7, 9, and 10 are subcategorized as aquaglyceroporins which permeabilize glycerol as well as water.	Water	98-103	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
23078817-1	2012	This review describes the discovery of rat aquaporin 2 AQP2 as a vasopressin-regulated water channel, and subsequent isolation of human AQP2.	Water	87-92	aquaporin 2	Rattus norvegicus	43-54
23776291-2	2013	Irradiation of 1 with visible light (lambdairr&gt;590 nm) in water results in the release of two equatorial CH3CN ligands, CH3CNeq, as well as in the formation of mononuclear radical Rh(II) fragments stemming from the homolytic photocleavage of the metal-metal bond.	Water	61-66	Rh blood group D antigen	Homo sapiens	183-189
23177919-0	2013	Silicic acid in drinking water prevents age-related alterations in the endothelium-dependent vascular relaxation modulating eNOS and AQP1 expression in experimental mice: an immunohistochemical study.	Water	25-30	nitric oxide synthase 3, endothelial cell	Mus musculus	124-128
23078817-1	2012	This review describes the discovery of rat aquaporin 2 AQP2 as a vasopressin-regulated water channel, and subsequent isolation of human AQP2.	Water	87-92	aquaporin 2	Rattus norvegicus	55-59
32267715-5	2020	Accumulating evidence in the literature indicates that the water-, glycerol-, and hydrogen peroxide-transporting channel aquaporin-3 (AQP3) plays a key role in various processes involved in keratinocyte function, and abnormalities in this channel have been observed in several human skin diseases.	Water	59-64	aquaporin 3 (Gill blood group)	Homo sapiens	134-138
32267715-6	2020	Here, we discuss the data linking AQP3 to keratinocyte proliferation, migration, differentiation, and survival as well as its role in skin properties and functions like hydration, water retention, wound healing, and barrier repair.	Water	180-185	aquaporin 3 (Gill blood group)	Homo sapiens	34-38
32655650-11	2020	AQP2 and GLUT2 downregulation may underlie water and osmotic diuresis, respectively.	Water	43-48	aquaporin 2	Rattus norvegicus	0-4
22722030-2	2012	Colitis was induced in CD1 male mice through the intake of 4% DSS in tap water for 7 days.	Water	73-78	CD1 antigen complex	Mus musculus	23-26
22923680-10	2012	Upon water stress, the overexpression of VvPIP2;4N induced a surge in leaf abscisic acid content and a decrease in stomatal conductance and leaf gas exchange.	Water	5-10	aquaporin PIP2	Vitis vinifera	41-47
22503590-8	2012	Substantial ingestion of Dead Sea water (generally in unusual near-drowning cases) is toxic and can result in cardiac rhythm disturbances because of electrolyte concentration abnormalities.	Water	34-39	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	30-33
22749905-0	2012	Electrochemical regeneration of field spent GAC from two water treatment plants.	Water	57-62	glutaminase	Homo sapiens	44-47
22913648-3	2012	Water plays an important role in promoting the reaction by activating the "CuCF(3)" species prepared from CuI/TMSCF(3)/CsF (1.0:1.1:1.1).	Water	0-5	colony stimulating factor 2	Homo sapiens	119-122
22963223-6	2012	The PEP for the addition of H(2)O to UO(2)(+) suggests that both UO(2)(+) (H(2)O) and UO(OH)(2)(+) should be considered as potential products.	Water	28-33	progestagen associated endometrial protein	Homo sapiens	4-7
23079979-1	2012	The insulin growth factor 1/phosphatase and tensin homologue deleted on chromosome 10/Akt/forkhead box (IGF-1/PTEN/Akt/FoxO) signaling pathway reportedly exhibits gastroprotective effects by reducing water immersion and restraint stress (WRS)-induced gastric mucosal cell apoptosis.	Water	200-205	insulin-like growth factor 1	Rattus norvegicus	104-109
22889803-3	2012	The X-ray coordinates of ligand 4a with cdk5 are also reported, showing an unusual binding mode to the hinge region via a water molecule.	Water	122-127	cyclin dependent kinase 5	Homo sapiens	40-44
22894550-6	2012	The MP2/aug-cc-pV5Z level is used to describe the electronic properties of the QM water.	Water	82-87	tryptase pseudogene 1	Homo sapiens	4-7
23240414-0	2012	[The measurement of methane dissolved in water using raman spectroscopy assisted with CCl4 extraction].	Water	41-46	C-C motif chemokine ligand 4	Homo sapiens	86-90
23240414-2	2012	In the present paper, a novel approach based on CCl4 extraction was introduced, and used in the measurement of methane dissolved in water using Raman spectroscopy under laboratory conditions.	Water	132-137	C-C motif chemokine ligand 4	Homo sapiens	48-52
22797179-0	2012	Aquaporin 2: not just for moving water.	Water	33-38	aquaporin 2	Homo sapiens	0-11
22722827-4	2012	METHODS: The sensitivity of PC-9 and PC-9/Met to SN-38 was assessed by performing water soluble tetrazolium salt (WST-1) assays.	Water	82-87	proprotein convertase subtilisin/kexin type 9	Homo sapiens	28-41
22735833-7	2012	The activity of AQP3 and cell migration were inhibited by PD153035,             U0126 and CuSO4 (AQP3 water transport inhibitor).	Water	102-107	aquaporin 3 (Gill blood group)	Homo sapiens	16-20
22735833-7	2012	The activity of AQP3 and cell migration were inhibited by PD153035,             U0126 and CuSO4 (AQP3 water transport inhibitor).	Water	102-107	aquaporin 3 (Gill blood group)	Homo sapiens	97-101
22803592-7	2012	The Mg(2+)-bound N-CaM structure also provides a unique view of a transiently bound hydrated metal ion and suggests a role for the hydration water in the metal-induced conformational change.	Water	141-146	neural cell adhesion molecule 1	Homo sapiens	17-22
22707093-0	2012	Spatial variation of bacterial community structure of the Northern South China Sea in relation to water chemistry.	Water	98-103	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	79-82
22880741-2	2012	Simulated behavioural fever, through a 2 5  C water temperature rise following bacterial lipopolysaccharide injection, enhanced the expression of the cytokine interleukin-1beta, in comparison with an untreated group held at the initial temperature.	Water	46-51	interleukin-1 beta	Oncorhynchus mykiss	159-176
22212485-6	2012	Furthermore, in contrast to the EGCG group, almost all ssDNA-positive cells in the water group co-localized with NeuN and nestin-staining.	Water	83-88	RNA binding fox-1 homolog 3	Rattus norvegicus	113-117
22863826-3	2012	We present a unique case of accidental ingestion of a large amount of Dead Sea water through a gastrostomy tube in which a patient with familial dysautonomia presented with severe electrolyte disturbances.	Water	79-84	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	75-78
23189723-7	2012	Compared with the normal group, within 7 days after the administration, water extracted components in 0.63-5.0 g x kg(-1) dose scope could cause significant damage to liver, the activity of ALT, AST, AKP, TBI elevated, while ALB reduced, and liver ratio increased, and under light microscope, the different doses" liver tissue of mice all had different degree"s edema, fatty degeneration in liver cells and interstitial congestion.	Water	72-77	glutamic pyruvic transaminase, soluble	Mus musculus	190-193
22686594-5	2012	Taken together, integrated analysis of omics data demonstrated that water and sodium reabsorption could be reduced by decreased extracellular osmolality per se, through decreased levels of ABC transporters and IRS2, which play a potential role in the transport of organic osmolytes, BCAA, glucose, and trafficking of epithelial sodium channel.	Water	68-73	insulin receptor substrate 2	Homo sapiens	210-214
22783187-5	2012	The difference (DeltaK(1)) between the blood-brain clearances (K(1)) of water (the current measure of CBF) and oxygen (the current measure of oxygen clearance) was reduced globally in AD and particularly in the parietal, occipital, and temporal lobes.	Water	72-77	CCAAT enhancer binding protein zeta	Homo sapiens	102-105
22751660-6	2012	A water molecule and Pro20beta in T. aquaticus take the place of Gln20beta in pig GTP-specific SCS, interacting well with the guanine base and other residues of the nucleotide-binding site.	Water	2-7	succinate-CoA ligase GDP/ADP-forming subunit alpha	Sus scrofa	95-98
22492943-2	2012	Aquaporin (AQP)2 water channels and urea transporter (UT)-A1 are inserted into the apical membrane upon phosphorylation of the channels to allow the transcellular movement of water and urea.	Water	17-22	aquaporin 2	Mus musculus	11-16
23458739-5	2013	CA1 LTP induced by a 100-Hz tetanus for 1s was inhibited in the presence of 2-amino-5-phosphonovalerate (APV), an N-methyl-d-aspartate (NMDA) receptor antagonist, in hippocampal slices from the control rats and was attenuated by water immersion stress.	Water	229-234	carbonic anhydrase 1	Rattus norvegicus	0-3
23505074-1	2013	Aquaporin 4 (AQP4) is the predominant water channel in the brain, expressed mainly in astrocytes and involved in water transport in physiologic and pathologic conditions.	Water	38-43	aquaporin 4	Rattus norvegicus	0-11
23505074-1	2013	Aquaporin 4 (AQP4) is the predominant water channel in the brain, expressed mainly in astrocytes and involved in water transport in physiologic and pathologic conditions.	Water	38-43	aquaporin 4	Rattus norvegicus	13-17
23505074-1	2013	Aquaporin 4 (AQP4) is the predominant water channel in the brain, expressed mainly in astrocytes and involved in water transport in physiologic and pathologic conditions.	Water	113-118	aquaporin 4	Rattus norvegicus	0-11
23505074-1	2013	Aquaporin 4 (AQP4) is the predominant water channel in the brain, expressed mainly in astrocytes and involved in water transport in physiologic and pathologic conditions.	Water	113-118	aquaporin 4	Rattus norvegicus	13-17
23505074-2	2013	Besides the classical isoforms M1 (a) and M23 (c), additional ones may be present at the plasma membrane, such as the recently described AQP4b, d, e, and f. Water permeability regulation by AQP4 isoforms may involve several processes, such as channel conformational changes, the extent and arrangement of channels at the plasma membrane, and the dynamics of channel trafficking to/from the plasma membrane.	Water	157-162	aquaporin 4	Rattus norvegicus	137-141
23947041-1	2013	In this study, we present a nanofiltration (NF90, NF270) pretreatment to increase the precision of dissolved organic nitrogen (DON) measurements in water samples.	Water	148-153	interleukin enhancer binding factor 3	Homo sapiens	44-48
24425948-3	2013	Exposure to fluoride through drinking water not only significantly increased plasma glucose and lipid profiles, but also elevated both hepatic and renal lipid peroxidation, hepatic lipid profiles and G-6-Pase activity with a reduction in plasma HDL-C, hepatic glycogen content, hexokinase activity and antioxidant status.	Water	38-43	hexokinase 2	Zea mays	278-288
23848685-9	2013	Diffusivity of water in both SAP-1 and SAP-2 are found to be lower in comparison to the bulk, and within the two samples of saponite clay diffusivity in SAP-1 is found to be lower compared to SAP-2; this has been explained on the basis of the charge on the tetrahedral layers and the charge balancing cations in the interlayer spacing.	Water	15-20	protein tyrosine phosphatase receptor type H	Homo sapiens	29-34
23718315-14	2013	The water fraction of BF showed the highest percentage of alpha-glucosidase inhibition while having the highest amount of protein (73.33 +- 4.99 mug/mg fraction).	Water	4-9	sucrase-isomaltase	Homo sapiens	58-75
23766672-7	2013	NMR relaxation parameters, especially the nonselective (R1(NS)) and selective (R1(SE)) spin-lattice relaxation rates of water protons, are useful for investigating the solvent dynamics at the macromolecule-solvent interfaces as well as the perturbation effects caused by the water-macromolecule interactions on the solvent dynamical properties.	Water	120-125	CD1b molecule	Homo sapiens	79-85
23582977-2	2013	Despite the decrease of radioactivity caused by radioactive decay, radionuclides have a prolonged residence time in the water of the Baltic Sea due to slow water exchange and relatively rapid sedimentation.	Water	120-125	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	140-143
23582977-2	2013	Despite the decrease of radioactivity caused by radioactive decay, radionuclides have a prolonged residence time in the water of the Baltic Sea due to slow water exchange and relatively rapid sedimentation.	Water	156-161	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	140-143
23590729-1	2013	Sodium salts of maleamic acid derivatives of lauryl ester of tyrosine (MTNa) and phenyl alanine (MPNa) in water exhibited strong pH-responsive behaviors of viscosity and specific conductivity that originate from the concentration and pH dependence of their aggregation states.	Water	106-111	methylthioribose-1-phosphate isomerase 1	Homo sapiens	71-75
23422169-2	2013	In surface waters used for municipal drinking water supplies, numerous pesticides and other anthropogenic chemicals have been found that inhibit AChE; however, there is currently no portable toxicity assay capable of determining the potential neurotoxicity of water samples and complex mixtures.	Water	11-16	acetylcholinesterase	Rattus norvegicus	145-149
23468083-6	2013	Brain water content was significantly decreased in the ipsilateral hemispheres of the Flk-1(+) hBMSC-treated rats when compared with the controls 3 days after ICH.	Water	6-11	kinase insert domain receptor	Rattus norvegicus	86-91
23395551-8	2013	Oral SIRT1 activator treatment administered to mice during the efferent phase (days7-14) of EAU was effective at suppressing disease.	Water	92-95	sirtuin 1	Mus musculus	5-10
23498245-2	2013	The LDH-MTX nanohybrid produced moderately stable suspension in water, as predicted by zeta potential measurement.	Water	64-69	metaxin 1	Homo sapiens	8-11
23420844-3	2013	Homology modeling of mGluR8 transmembrane domain with rhodopsin as a template suggested the presence of a conserved water-mediated hydrogen-bonding network between helices VI and VII, which presumably constrains the receptor in an inactive conformation.	Water	116-121	glutamate receptor, metabotropic 8	Mus musculus	21-27
23360744-1	2013	The water channel aquaporin-2 (AQP2), expressed in the kidney collecting ducts, plays a pivotal role in maintaining body water balance.	Water	4-9	aquaporin 2	Homo sapiens	31-35
23224355-2	2013	We performed several 30-ns MD simulations of cytochrome c (Cyt c) in a water box for temperatures ranging from 110 to 300 K and compared the results with those from experimental inelastic neutron scattering.	Water	71-76	cytochrome c, somatic	Equus caballus	45-57
23224355-2	2013	We performed several 30-ns MD simulations of cytochrome c (Cyt c) in a water box for temperatures ranging from 110 to 300 K and compared the results with those from experimental inelastic neutron scattering.	Water	71-76	cytochrome c, somatic	Equus caballus	59-64
23290745-0	2013	Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation.	Water	79-84	aquaporin 7	Mus musculus	55-59
23473857-0	2013	Immunolocalization and translocation of aquaporin-5 water channel in sweat glands.	Water	52-57	aquaporin 5	Homo sapiens	40-51
23473857-9	2013	CONCLUSION: The regulated AQP5 translocation may contribute to sweat secretion by increasing the water permeability of apical plasma membranes of sweat glands.	Water	97-102	aquaporin 5	Homo sapiens	26-30
23539603-4	2013	The 3.4 angstrom crystal structure of human ZMPSTE24 has a seven transmembrane alpha-helical barrel structure, surrounding a large, water-filled, intramembrane chamber, capped by a zinc metalloprotease domain with the catalytic site facing into the chamber.	Water	132-137	zinc metallopeptidase STE24	Homo sapiens	44-52
23556733-3	2013	This study reports a determination of the water proton coordinates in unit cell of structure I (sI), II (sII), and H (sH) clathrate hydrates that satisfy the ice rules, have the lowest potential energy configuration for the protons, and give a net zero dipole moment.	Water	42-47	transcription elongation factor A1	Homo sapiens	105-108
23458706-10	2013	Results from these HHP experiments suggest water release accompanies binding of both the cofactor and DHF to R67 DHFR.	Water	43-48	dihydrofolate reductase	Homo sapiens	113-117
23458706-11	2013	In an additional set of experiments, isothermal titration calorimetry studies in H2O and D2O find that water reorganization dominates the enthalpy associated with binding of DHF to R67 DHFR NADP(+), while no obvious effects occur for cofactor binding.	Water	103-108	dihydrofolate reductase	Homo sapiens	185-189
23458706-12	2013	The combined results indicate that water plays an active role in ligand binding to R67 DHFR.	Water	35-40	dihydrofolate reductase	Homo sapiens	87-91
23321219-4	2013	The protonation constants of H(4)L were also measured in DMSO-water (1:10) mixture.	Water	62-67	H4 clustered histone 7	Homo sapiens	29-34
23334151-1	2013	A novel, simple but highly selective fluorescent probe is developed for the direct detection of sulfide ions [S(2-)] based on the fluorescence quenching of the functionalized CdS QDs in aqueous solution at trace levels and successfully applied for quantitation of S(2-) from water samples in a complex matrix exclusive of pretreatment by standard addition method.	Water	275-280	CDP-diacylglycerol synthase 1	Homo sapiens	175-178
22526928-4	2012	M1 water treatment increased the mRNA and protein levels of glucose regulation protein 78 (GRP78) and C/EBP homologous protein (CHOP), and decreased the mRNA levels of B-cell lymphoma 2 (Bcl-2).	Water	3-8	DNA-damage inducible transcript 3	Mus musculus	102-126
22526928-4	2012	M1 water treatment increased the mRNA and protein levels of glucose regulation protein 78 (GRP78) and C/EBP homologous protein (CHOP), and decreased the mRNA levels of B-cell lymphoma 2 (Bcl-2).	Water	3-8	DNA-damage inducible transcript 3	Mus musculus	128-132
22526928-7	2012	M1 water exposure up-regulated GRP78 mRNA and protein expression and CHOP mRNA expression, whereas M2 water treatment up-regulated caspase-12 and Bcl-2 mRNA expression.	Water	3-8	DNA-damage inducible transcript 3	Mus musculus	69-73
22579869-1	2012	In this study, a water-soluble polysaccharide (PPS) from Dictyophora indusiata was purified and investigated through a combination of gel chromatography (Sephadex G-200), infrared (IR) spectroscopy, and gas chromatography-mass spectrometry (GC-MS).	Water	17-22	inositol polyphosphate-5-phosphatase K	Homo sapiens	47-50
32655650-11	2020	AQP2 and GLUT2 downregulation may underlie water and osmotic diuresis, respectively.	Water	43-48	solute carrier family 2 member 2	Rattus norvegicus	9-14
31811327-9	2020	Consistently, SAL protected cardiomyocytes against H2O2-induced H9c2 damage through increasing cell viability, decreasing cell apoptosis, and activating Trx and inhibiting JNK.	Water	51-55	mitogen-activated protein kinase 8	Rattus norvegicus	172-175
22908561-4	2012	The cPLA2 and sPLA2 activities were inhibited in vitro by asiaticoside present in the water extract of C. asiatica.	Water	86-91	phospholipase A2 group IVA	Rattus norvegicus	4-9
22568547-12	2012	The BP86 method shows more spectral features, and the best fit was found for a GS-Cbl model with 5,6-dimethylbenzimidazole at the BP86/6-311G(d,p) level with a water cpcm solvent model.	Water	160-165	Cbl proto-oncogene	Homo sapiens	82-85
23180003-1	2013	The maintenance of water homeostasis under pathological conditions is mediated by the aquaporin-4 (AQP4) channel in astrocytes.	Water	19-24	aquaporin 4	Rattus norvegicus	86-97
23180003-1	2013	The maintenance of water homeostasis under pathological conditions is mediated by the aquaporin-4 (AQP4) channel in astrocytes.	Water	19-24	aquaporin 4	Rattus norvegicus	99-103
32277833-3	2020	PPL1 is a homolog of PsbP protein which optimizes the water-oxidizing reaction of PSII in green plants and is required for the efficient repair of photodamaged PSII; however, its exact function has been unknown.	Water	54-59	PsbP-like protein 1	Arabidopsis thaliana	0-4
23371779-2	2013	In this work, sodium chloride and ACN were used as the salting-out agent and water-soluble extraction solvent, respectively.	Water	77-82	apoptotic chromatin condensation inducer 1	Homo sapiens	34-37
22455374-1	2012	The effect of a single water molecule on the reaction between H(2)O(2) and HO has been investigated by employing MP2 and CCSD(T) theoretical approaches in connection with the aug-cc-PVDZ, aug-cc-PVTZ, and aug-cc-PVQZ basis sets and extrapolation to an   basis set.	Water	23-28	tryptase pseudogene 1	Homo sapiens	113-116
22624583-8	2012	By means of CASTp server, we have found seven cavities/pockets scattered throughout of the CD2BP2-GYF structure, each able to harbor at least one water molecule.	Water	146-151	calpastatin	Homo sapiens	12-17
23398174-1	2013	alpha-Synuclein (alphaS) is an intrinsically disordered protein that is water-soluble but also can bind negatively charged lipid membranes while adopting an alpha-helical conformation.	Water	72-77	synuclein alpha	Homo sapiens	0-15
32486465-0	2020	Measurement of Water Velocity in Gas-Water Two-Phase Flow with the Combination of Electromagnetic Flowmeter and Conductance Sensor.	Water	15-20	gastrin	Homo sapiens	33-36
23398174-7	2013	When not bound to membrane, oxidized Met1 and Met5 of alphaS are excellent substrates for methionine sulfoxide reductase (Msr), thereby providing an efficient vehicle for water-soluble Msr enzymes to protect the membrane against oxidative damage.	Water	171-176	granzyme M	Homo sapiens	37-41
23265176-7	2013	We show that reduced water content facilitates the formation of structures such as EMT that are challenging to synthesize in organic-free media and reduces the synthesis temperature required to achieve higher-density framework types.	Water	21-26	IL2 inducible T cell kinase	Homo sapiens	83-86
22609355-5	2012	Knockdown of MCRS2 expression accelerated p38 and JNK phosphorylation and promoted apoptosis in response to H(2)O(2).	Water	108-113	microspherule protein 1	Homo sapiens	13-18
32486465-0	2020	Measurement of Water Velocity in Gas-Water Two-Phase Flow with the Combination of Electromagnetic Flowmeter and Conductance Sensor.	Water	37-42	gastrin	Homo sapiens	33-36
22562405-3	2012	The prepared 3D SrS/CdS exhibited improved photocatalytic activity for water splitting leading to H(2) generation (AQY 10%) and nearly complete degradation of methyl orange (MO) dye.	Water	71-76	CDP-diacylglycerol synthase 1	Homo sapiens	20-23
32486465-1	2020	A method to measure the superficial velocity of the water phase in gas-water flow using an electromagnetic flowmeter (EMF) and rotating electric field conductance sensors (REFCSs) is introduced in this paper.	Water	52-57	gastrin	Homo sapiens	67-70
32486465-1	2020	A method to measure the superficial velocity of the water phase in gas-water flow using an electromagnetic flowmeter (EMF) and rotating electric field conductance sensors (REFCSs) is introduced in this paper.	Water	71-76	gastrin	Homo sapiens	67-70
32486465-2	2020	An electromagnetic flowmeter instrument factor model is built and the correlation between electromagnetic flowmeter output and gas holdup in different flow patterns are explored through vertical upward gas-water flow dynamic experiments in a pipe with an inner diameter (ID) of 20 mm.	Water	206-211	gastrin	Homo sapiens	202-205
22591491-2	2012	Less toxic C17-substituted analogues have been synthesizedincluding 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) and the water-soluble 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG).	Water	126-131	cytokine like 1	Homo sapiens	11-14
32486465-5	2020	The output of the electromagnetic flowmeter is unstable and invalid in slug flows with a water cut below 60% due to the non-conducting gas slug is almost filling the pipe.	Water	89-94	gastrin	Homo sapiens	135-138
23382199-1	2013	Aldoxime dehydratase (OxdA), which is a unique heme protein, catalyzes the dehydration of an aldoxime to a nitrile even in the presence of water in the reaction mixture.	Water	139-144	D-amino acid oxidase	Homo sapiens	22-26
32469934-0	2020	Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells.	Water	50-55	aquaporin 3 (Gill blood group)	Homo sapiens	85-89
23200346-2	2013	SANS reveals that hydrotropes induce cylindrical morphologies which transition to ellipsoidal and then spherical geometries with increasing water content (w).	Water	140-145	USH1 protein network component sans	Homo sapiens	0-4
22150518-8	2012	It is concluded that AQP1 is present in certain neuronal subsets of the ovine trigeminal ganglion; however, the exact role of this water channel has to be elucidated.	Water	131-136	aquaporin-1	Ovis aries	21-25
32469934-1	2020	In epithelial cells, the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated Cl- channel, plays a key role in water and electrolytes secretion.	Water	135-140	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	25-76
20457230-5	2012	The results indicate that the Hdh(Q150/Q150) mice were impaired on each of the measures used, with deficits appearing on a 3-stage water maze test at 4 months of age and on prepulse inhibition at 6 months of age, both of which were prior to the manifestation of motor abnormalities.	Water	131-136	huntingtin	Mus musculus	30-33
23505344-0	2013	A computational study of water and CO migration sites and channels inside myoglobin.	Water	25-30	myoglobin	Homo sapiens	74-83
32469934-1	2020	In epithelial cells, the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated Cl- channel, plays a key role in water and electrolytes secretion.	Water	135-140	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	78-82
23505344-1	2013	Pathways are computed for transport of H2O and CO in myoglobin (Mb), using the single sweep and zero-temperature string methods in a fully atomistic, explicitly solvated model system.	Water	39-42	myoglobin	Homo sapiens	53-62
32469934-8	2020	Readdressing the F508del-CFTR protein to the cell surface with VX-809 increased the detected water efflux in CHO but not in CFBE cells.	Water	93-98	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	25-29
22866392-1	2012	Iron-impregnated granular activated carbons (Fe-GAC) can remove arsenic effectively from water.	Water	89-94	glutaminase	Homo sapiens	48-51
32469934-11	2020	We identified a CFTR and cAMP-dependent, mercury-sensitive water transport in airway epithelial and CHO cells that might be due to AQP3.	Water	59-64	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	16-20
32469934-12	2020	This water transport appears to be affected when CFTR is mutated and independent of the chloride channel function of CFTR.	Water	5-10	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	49-53
32374318-0	2020	N-Promoted Ru1/TiO2 single-atom catalysts for photocatalytic water splitting for hydrogen production: a density functional theory study.	Water	61-66	Scm like with four mbt domains 1	Homo sapiens	11-14
22476323-1	2012	A crystalline porous organic cage molecule, CC3, is shown to adsorb up to 20.1 wt% water reversibly.	Water	83-88	C-C motif chemokine ligand 14	Homo sapiens	44-47
22476323-3	2012	Crystals of CC3 are stable in boiling water for at least 4 h. The surprising chemical and supramolecular stability of these imine-based molecular crystals suggests scope for practical applications in humid environments.	Water	38-43	C-C motif chemokine ligand 14	Homo sapiens	12-15
24285991-9	2013	At 7 days post-ischemia, the number of surviving hippocampal CA1 neurons was significantly higher in the treated mice than in the water-treated controls.	Water	130-135	carbonic anhydrase 1	Mus musculus	61-64
23081956-8	2013	For the orthotopic PC3-MM2 tumor, implanted in VP, the tCr/water ratio was significantly lower (3.1 +- 0.9) than neighboring DP (12.8 +- 1.8, P &lt; 0.00003) and healthy VP (15.3 +- 3.0, P &lt; 0.00006).	Water	59-64	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	19-22
32374318-1	2020	We propose a universal dimer-doping strategy to improve the photocatalytic water splitting activity of Ru1/TiO2 single-atom catalysts, in which the N atom is simultaneously doped.	Water	75-80	Scm like with four mbt domains 1	Homo sapiens	103-106
32432927-2	2020	The collecting duct water channel aquaporin-2 (AQP2) plays an essential role in this homeostatic response by facilitating water reabsorption along osmotic gradients.	Water	20-25	aquaporin 2	Homo sapiens	47-51
22938591-1	2013	This study aimed to assess the influence of water treatment and distribution on the bacterial communities with particular emphasis on tap water.	Water	138-143	filamin B	Homo sapiens	134-137
22938591-8	2013	Despite the effectiveness of water treatment to eliminate or inactivate most of the bacteria, Proteobacteria such as Acinetobacter, Bosea and Sphingomonadaceae may successfully colonize tap water.	Water	190-195	filamin B	Homo sapiens	186-189
22504638-9	2012	Differences in the sensitivity of STAT6 in astrocytes (highly sensitive) and microglia (insensitive) to phosphorylation following brief exposure to H(2)O(2) suggest that astrocytes can act as sentinels for certain stimuli, including H(2)O(2) and ROS, refining the canonical notion that microglia are the first line of defense against external stimuli.	Water	148-153	signal transducer and activator of transcription 6	Homo sapiens	34-39
22504638-9	2012	Differences in the sensitivity of STAT6 in astrocytes (highly sensitive) and microglia (insensitive) to phosphorylation following brief exposure to H(2)O(2) suggest that astrocytes can act as sentinels for certain stimuli, including H(2)O(2) and ROS, refining the canonical notion that microglia are the first line of defense against external stimuli.	Water	233-238	signal transducer and activator of transcription 6	Homo sapiens	34-39
22594440-6	2012	The application of different multivariate statistical techniques such as Cluster Analysis (CA), Principal Component Analysis (PCA), Absolute Principal Component Scores (APCS) for interpretation of the complex databases offers a better understanding of water quality in the study region.	Water	252-257	amyloid P component, serum	Homo sapiens	169-173
32432927-3	2020	The ability to increase the levels of AQP2 in the apical plasma membrane following an increase in plasma osmolality is a rate-limiting step in water reabsorption, a process that is tightly regulated by the antidiuretic hormone arginine vasopressin (AVP).	Water	143-148	aquaporin 2	Homo sapiens	38-42
32336090-4	2020	With this method, hexa-arm M-OEGs with 54 symmetrical fluorines were synthesized in 2 steps as a water soluble, self-assemble, 19F MRI sensitive and biocompatible dendritic biomaterial .	Water	97-102	hexosaminidase subunit alpha	Homo sapiens	18-22
22509818-1	2012	Water-dispersible CdS quantum dots (QDs) emitting from 510 to 650 nm were synthesized in a simple one-pot noninjection hydrothermal route using cadmium chloride, thiourea, and 3-mercaptopropionic acid (MPA) as starting materials.	Water	0-5	CDP-diacylglycerol synthase 1	Homo sapiens	18-21
22865465-4	2013	Tensile testing of CDM, fibrin gel and collagen gel rings treated with deionized water to lyse cells showed little to no change in mechanical properties relative to untreated ring samples, indicating that the ECM dominates the measured ring mechanics.	Water	81-86	multimerin 1	Homo sapiens	209-212
32171098-2	2020	The new generation of Neosepta cation exchange membrane (CSE) showed a significant difference in water uptake and co-ion sorption compared to the earlier generation (CMX).	Water	97-102	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	57-60
22357292-5	2012	The PHO13-disrupted strain produced ethanol from rice straw hydrolysate obtained by liquid hot-water pretreatment with a greater than fourfold higher xylose consumption rate than the control.	Water	95-100	4-nitrophenylphosphatase	Saccharomyces cerevisiae S288C	4-9
32509154-4	2020	However, AP has poor water and fat solubility, which determines its low oral bioavailability.	Water	21-26	LIM homeobox protein 2	Mus musculus	9-11
22449442-2	2012	Diabetes is known to alter the amount of retinal expression of the water-selective channels aquaporin 4 (AQP4).	Water	67-72	aquaporin 4	Rattus norvegicus	92-103
22843140-9	2013	In addition, exposure to ion-poor water caused a significant increase in claudin-b abundance as well as a decrease in Na(+) efflux, suggesting a possible role for claudin-b in regulating paracellular Na(+) loss.	Water	34-39	claudin b	Danio rerio	73-82
22843140-9	2013	In addition, exposure to ion-poor water caused a significant increase in claudin-b abundance as well as a decrease in Na(+) efflux, suggesting a possible role for claudin-b in regulating paracellular Na(+) loss.	Water	34-39	claudin b	Danio rerio	163-172
22449442-2	2012	Diabetes is known to alter the amount of retinal expression of the water-selective channels aquaporin 4 (AQP4).	Water	67-72	aquaporin 4	Rattus norvegicus	105-109
23201288-6	2013	In case of MS2 detection, the best method depended upon the type of water although Method 1 provided the most consistent recovery.	Water	68-73	MS2	Homo sapiens	11-14
32477057-7	2020	Results: Compared with WT mice, Trpv4-/- mice showed reduced ischemia-induced lesion volume and reduced water content and Evans blue leakage in the ipsilateral hemisphere alongside milder neurological symptoms.	Water	104-109	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	32-37
24049712-3	2013	EAU was induced by immunization of HLA-DR3 mice with arrestin or arrestin peptide and treated with RTLs by subcutaneous delivery.	Water	0-3	S-antigen, retina and pineal gland (arrestin)	Mus musculus	53-61
24049712-3	2013	EAU was induced by immunization of HLA-DR3 mice with arrestin or arrestin peptide and treated with RTLs by subcutaneous delivery.	Water	0-3	S-antigen, retina and pineal gland (arrestin)	Mus musculus	65-73
22354093-4	2012	In a dioxane/water (1 : 1, v/v) mixture, intensity and spectral position of luminescence have been found to drastically depend on the pH/H0 values of the solutions (pH 5/H0-2 range) due to subsequent protonations (four steps) as the acidity of the solution changes.	Water	13-18	H1.5 linker histone, cluster member	Homo sapiens	170-174
32478126-1	2020	In this work, second-generation Car-Parrinello-based mixed quantum-classical mechanics molecular dynamics simulations of small nanoparticles of NbP, NbAs, TaAs, and 1T-TaS2 in water are presented.	Water	176-181	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	144-147
22475110-0	2012	Adsorption of beta-casein-surfactant mixed layers at the air-water interface evaluated by interfacial rheology.	Water	61-66	casein beta	Homo sapiens	14-25
26589058-4	2013	Its derivative is the best approximation for the force acting on the AFM tip, including entropic contributions from interactions with water molecules in hydration layers over the surface and around the tip apex.	Water	134-139	TOR signaling pathway regulator	Homo sapiens	73-76
32478126-4	2020	The results presented herein allow explaining the catalytic activity of these Weyl semimetals: the most active material, NbP, exhibits a particularly low water coordination near the surface of the nanoparticle, whereas for 1T-TaS2, with the lowest catalytic activity, the water structure at the surface is most ordered.	Water	154-159	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	121-124
24109632-1	2013	Diffusion weighted magnetic resonance imaging (dMRI) is used to measure, in vivo, the self-diffusion of water molecules in biological tissues.	Water	104-109	mrityu	Drosophila melanogaster	47-51
22685356-1	2012	Aquaporin 2 (AQP2) is a membrane water channel protein that traffics between the intracellular membrane compartment and the plasma membrane in a vasopressin-dependent manner in the renal collecting duct cell to control the amount of water reabsorption.	Water	33-38	aquaporin 2	Canis lupus familiaris	0-11
22685356-1	2012	Aquaporin 2 (AQP2) is a membrane water channel protein that traffics between the intracellular membrane compartment and the plasma membrane in a vasopressin-dependent manner in the renal collecting duct cell to control the amount of water reabsorption.	Water	33-38	aquaporin 2	Canis lupus familiaris	13-17
32478126-4	2020	The results presented herein allow explaining the catalytic activity of these Weyl semimetals: the most active material, NbP, exhibits a particularly low water coordination near the surface of the nanoparticle, whereas for 1T-TaS2, with the lowest catalytic activity, the water structure at the surface is most ordered.	Water	272-277	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	121-124
32455182-6	2020	During water oxidation catalysis, NiO x -SC/FTO initiates the oxygen evolution reaction (OER) at an overpotential eta of just 250 mV while generating current decade at just 300 mV and demonstrates well-balanced kinetics toward OER.	Water	7-12	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	44-47
22439732-3	2012	Equilibrium unfolding of the U(B) state is accompanied by an unusual expansion of the chain involving an intermediate, I(alc), from which water is preferentially excluded, the extent of water exclusion being greater with the hydrocarbon content of the alcohol.	Water	138-143	allantoicase	Homo sapiens	121-124
22439732-3	2012	Equilibrium unfolding of the U(B) state is accompanied by an unusual expansion of the chain involving an intermediate, I(alc), from which water is preferentially excluded, the extent of water exclusion being greater with the hydrocarbon content of the alcohol.	Water	186-191	allantoicase	Homo sapiens	121-124
22439732-6	2012	The fact that the I(alc) state populates at low concentrations of methanol and ethanol and the fact that the extent of chain expansion in this state approaches that of the U(B) state indicate a definite influence of electrostatic repulsion severed by the low dielectric of the water/alcohol mixture.	Water	277-282	allantoicase	Homo sapiens	20-23
22439732-7	2012	Interestingly, the U(B)   I(alc) segment of the U(B)   I(alc)   U equilibrium, where U is the unfolded state, accounts for roughly 85% of the total number of water molecules preferentially excluded in unfolding.	Water	158-163	allantoicase	Homo sapiens	28-31
22439732-7	2012	Interestingly, the U(B)   I(alc) segment of the U(B)   I(alc)   U equilibrium, where U is the unfolded state, accounts for roughly 85% of the total number of water molecules preferentially excluded in unfolding.	Water	158-163	allantoicase	Homo sapiens	57-60
23046410-7	2013	On the basis of structural modelling and comparison, as well as large-scale sequence alignment studies, we further determined that the catalytic mechanism of Cg1458 is actually through a glutamic acid-histidine-water triad, and this catalytic triad is common among FAH family proteins that catalyse the cleavage of the C-C bond of the substrate.	Water	211-216	fumarylacetoacetate hydrolase	Homo sapiens	265-268
23924471-8	2013	RESULTS: In both the TBI+saline group and the TBI+AG490 group, the brain water content was elevated after TBI, reached a peak at 24-hour and remained high for the rest of the period investigated; the expression of CD40 reached a peak 24 hours after TBI; the NSS was elevated after TBI and then decreased after 6 hours.	Water	73-78	CD40 molecule	Rattus norvegicus	214-218
22237797-0	2012	mPGES-1 deletion potentiates urine concentrating capability after water deprivation.	Water	66-71	prostaglandin E synthase	Mus musculus	0-7
32212617-9	2020	In situ X-ray absorption spectroscopy data confirmed that approximately 10% of the single Pd atoms in the Pd4+ state were reduced to Pd2+ during exposure to 1000 ppm H2, implying that a Pd4+   Pd2+ catalytic redox cycle accelerates the water formation reaction during hydrogen sensing.	Water	236-241	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	133-136
22237797-2	2012	The present study was undertaken to investigate the potential role of microsomal PGE synthase (mPGES)-1 in the regulation of urine concentrating ability after water deprivation (WD).	Water	159-164	prostaglandin E synthase	Mus musculus	70-103
22680232-3	2013	We suggest that gastrin is involved in the regulation of blood pressure, possibly via the regulation of sodium and water metabolism and/or renin-angiotensin-aldosterone system.	Water	115-120	gastrin	Homo sapiens	16-23
32212617-9	2020	In situ X-ray absorption spectroscopy data confirmed that approximately 10% of the single Pd atoms in the Pd4+ state were reduced to Pd2+ during exposure to 1000 ppm H2, implying that a Pd4+   Pd2+ catalytic redox cycle accelerates the water formation reaction during hydrogen sensing.	Water	236-241	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	193-196
22301619-5	2012	We found that under a standard Na(+) diet, renal water and Na(+)/K(+) excretion had a tendency to be higher in doxycycline-treated Sgk1 KO mice compared with control mice.	Water	49-54	serum/glucocorticoid regulated kinase 1	Mus musculus	131-135
32270558-3	2020	The as-prepared membrane with durable mechanical and chemical stabilities achieves separation efficiency higher than 99.9% and high flux up to 632.5 L m-2 h-1 bar-1 for different water-in-oil emulsions.	Water	179-184	H1.5 linker histone, cluster member	Homo sapiens	155-158
22306510-5	2012	Additionally, it was demonstrated that knockdown of RhitH or overexpression of M-LPH reduces the generation of intracellular H(2)O(2) and loss of mitochondrial membrane potential caused by an inhibitor of the respiratory chain, antimycin A.	Water	125-130	zinc finger protein 205	Homo sapiens	52-57
23116402-1	2013	The primary role of the water-soluble vitamin B2, i.e. riboflavin, in cell biology is connected with its conversion into FMN and FAD, the cofactors of a large number of dehydrogenases, reductases and oxidases involved in energetic metabolism, redox homeostasis and protein folding as well as in diverse regulatory events.	Water	24-29	formin 1	Homo sapiens	121-124
24185376-0	2013	Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme.	Water	6-11	dipeptidyl peptidase 4	Homo sapiens	59-82
31990075-3	2020	In this work, the catalase-deficient Arabidopsis mutant, cat2, was exploited to elucidate the impact of S-NITROSOGLUTATHIONE REDUCTASE1 (GSNOR1) on H2 O2 -dependent signaling pathways.	Water	148-153	cationic amino acid transporter 2	Arabidopsis thaliana	57-61
24185376-0	2013	Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme.	Water	6-11	dipeptidyl peptidase 4	Homo sapiens	91-95
23606883-4	2013	The effects of the plant extracts (50% ethanol in water) on glucose transporter-4 (GLUT4) translocation to the plasma membrane was tested in an ELISA test on L6-GLUT4myc cells.	Water	50-55	solute carrier family 2 member 4	Rattus norvegicus	60-81
22205228-11	2012	Thus we propose that structural or functional loss of cilia leads to abnormal trafficking of AQP2/V2R leading to enhanced salt and water absorption.	Water	131-136	aquaporin 2	Mus musculus	93-97
22316066-6	2012	As a model system, we prepared Langmuir monolayers of PAF and lyso-PAF at the air/water interface.	Water	82-87	PCNA clamp associated factor	Homo sapiens	54-57
23606883-4	2013	The effects of the plant extracts (50% ethanol in water) on glucose transporter-4 (GLUT4) translocation to the plasma membrane was tested in an ELISA test on L6-GLUT4myc cells.	Water	50-55	solute carrier family 2 member 4	Rattus norvegicus	83-88
22316066-6	2012	As a model system, we prepared Langmuir monolayers of PAF and lyso-PAF at the air/water interface.	Water	82-87	PCNA clamp associated factor	Homo sapiens	67-70
31990075-5	2020	Differential transcriptome profiles between gsnor1-3 and cat2 gsnor1-3 together with damped ROS-triggered gene expression in cat2 gsnor1-3 further indicated that GSNOR1 acts to mediate the SA pathway downstream of H2 O2 .	Water	214-219	cationic amino acid transporter 2	Arabidopsis thaliana	125-129
32372285-0	2020	SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na+] sensor for the control of water intake.	Water	95-100	solute carrier family 9 (sodium/hydrogen exchanger), member 4	Mus musculus	0-6
32372285-2	2020	We previously demonstrated that Nax signals are involved in the control of water intake behavior through the Nax/TRPV4 pathway.	Water	75-80	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	113-118
22262283-9	2012	The MIP-QCM sensor was used to detect profenofos in tap water, and showed good recovery and repeatability.	Water	56-61	filamin B	Homo sapiens	52-55
24601014-6	2013	The reactivity of BaP was enhanced at -50% relative humidity (RH) suggesting that water uptake lowers the viscosity of the SOA, hence lifting the mass transfer constraint to some degree.	Water	82-87	prohibitin 2	Homo sapiens	18-21
32981278-3	2020	The changes of learning and memory ability of SCA3 mice before and after the intervention of different doses of NaHS were determined by Morris water maze, the content of hydrogen sulfide (H2S) in hippocampus was measured by spectrophotometry, the expression of MBP was detected by immunohistochemistry, and the morphological changes of neuron myelin sheath were observed by electron microscope.	Water	143-148	ataxin 3	Mus musculus	46-50
22324786-4	2012	The accuracy of these EFP potentials is justified by comparison of structures and binding energies in water, TBA, and water-TBA dimers with MP2/6-311++G(d,p) data.	Water	102-107	tryptase pseudogene 1	Homo sapiens	140-143
22324786-4	2012	The accuracy of these EFP potentials is justified by comparison of structures and binding energies in water, TBA, and water-TBA dimers with MP2/6-311++G(d,p) data.	Water	118-123	tryptase pseudogene 1	Homo sapiens	140-143
32239008-0	2020	Hot-water extract of ripened Pu-erh tea attenuates DSS-induced colitis through modulation of the NF-kappaB and HIF-1alpha signaling pathways in mice.	Water	4-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	111-121
22247459-8	2012	Western blot analysis showed that the level of ALDH1A1 protein per cell was similar between myofibroblasts and keratocytes, but was substantially reduced as a percentage of total water-soluble protein.	Water	179-184	aldehyde dehydrogenase 1 family member A1	Homo sapiens	47-54
23018383-9	2013	Challenge with proteins from raw egg, water-boiled egg and fried egg induced skewed T-helper 2 pattern responses (Th2 responses) in the intestine of mice sensitized to egg proteins; however, when the mice sensitized to egg proteins were challenged with proteins from steamed egg, spiced egg and tea-boiled egg, respectively, only weak Th2 responses were induced in their intestine.	Water	38-43	heart and neural crest derivatives expressed 2	Mus musculus	114-117
23018383-9	2013	Challenge with proteins from raw egg, water-boiled egg and fried egg induced skewed T-helper 2 pattern responses (Th2 responses) in the intestine of mice sensitized to egg proteins; however, when the mice sensitized to egg proteins were challenged with proteins from steamed egg, spiced egg and tea-boiled egg, respectively, only weak Th2 responses were induced in their intestine.	Water	38-43	heart and neural crest derivatives expressed 2	Mus musculus	335-338
23857302-4	2013	With 20% of the global new-water sea level rise coming from Alaska, partitioning of mass loss sources in Alaska is needed to improve sea level rise projections.	Water	27-32	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	33-36
22159182-1	2012	Reactions of the tertiary phosphines R(3)P (R = Me, Bu, Oct, Cy, Ph) with 35% aqueous H(2)O(2) gives the corresponding oxides as the H(2)O(2) adducts R(3)P=O (H(2)O(2))(x) (x = 0.5-1.0).	Water	86-91	plexin A2	Homo sapiens	56-59
32259485-6	2020	Ablation of vagal P2RY1 neurons eliminates protective responses to laryngeal water and acid challenge.	Water	77-82	purinergic receptor P2Y, G-protein coupled 1	Mus musculus	18-23
32341391-1	2020	It"s a significant challenge for gas-water flow transition characteristics from experimental measurements in the study of multiphase flow systems.	Water	37-42	gastrin	Homo sapiens	33-36
22158710-12	2012	CONCLUSIONS: H(2)O(2) dilates HCAs through a novel mechanism involving protein dimerization and activation of PKG-Ialpha and subsequent opening of smooth muscle BK(Ca) channels.	Water	13-18	protein kinase cGMP-dependent 1	Homo sapiens	110-113
22776546-7	2013	After a 10 week treatment with either of these PDE5 inhibitors, the performance of the J20 mice in the Morris water maze test improved when compared with the transgenic mice that received vehicle.	Water	110-115	phosphodiesterase 5A, cGMP-specific	Mus musculus	47-51
32341391-3	2020	In order to uncovering gas-water flow transitions, gas-water flow experiment was carried out to obtain time series signals related to the transitions of three flow patterns.	Water	27-32	gastrin	Homo sapiens	23-26
32341391-3	2020	In order to uncovering gas-water flow transitions, gas-water flow experiment was carried out to obtain time series signals related to the transitions of three flow patterns.	Water	55-60	gastrin	Homo sapiens	51-54
23577216-1	2013	The Bohai Sea is a large semi-enclosed shallow water basin, which receives extensive river discharges of various terrestrial and anthropogenic materials such as sediments, nutrients and contaminants.	Water	47-52	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	10-13
21993890-1	2012	The degree of water transport via aquaporin-2 (AQP2) water channels in renal collecting duct principal cells is reflected by the level of the urinary excretion of AQP2 (u-AQP2).	Water	53-58	aquaporin 2	Homo sapiens	47-51
21993890-1	2012	The degree of water transport via aquaporin-2 (AQP2) water channels in renal collecting duct principal cells is reflected by the level of the urinary excretion of AQP2 (u-AQP2).	Water	53-58	aquaporin 2	Homo sapiens	163-167
32341391-6	2020	The results show that the multiscale limited penetrable visibility graph can not only effectively characterize flow transition but also yields novel insights into the identification of gas-water flow patterns.	Water	189-194	gastrin	Homo sapiens	185-188
21993890-1	2012	The degree of water transport via aquaporin-2 (AQP2) water channels in renal collecting duct principal cells is reflected by the level of the urinary excretion of AQP2 (u-AQP2).	Water	53-58	aquaporin 2	Homo sapiens	169-175
21993890-9	2012	In conclusion, u-AQP2 was increased during HS intake, indicating that water transport via AQP2 was increased.	Water	70-75	aquaporin 2	Homo sapiens	15-21
32340133-3	2020	MW was obtained by circulating tap water (TW) through a magnetic field.	Water	35-40	target of Poxn	Drosophila melanogaster	31-34
21993890-9	2012	In conclusion, u-AQP2 was increased during HS intake, indicating that water transport via AQP2 was increased.	Water	70-75	aquaporin 2	Homo sapiens	17-21
23468877-13	2013	CuSO4, a water transport inhibitor selective for AQP3, also suppressed FGF-2-induced cell migration.	Water	9-14	aquaporin 3 (Gill blood group)	Homo sapiens	49-53
32300112-2	2020	For many coastal regions, projections of global sea-level rise by the year 2100 (e.g., 0.5-2 meters) are comparable in magnitude to today"s extreme but short-lived increases in water level due to storms.	Water	177-182	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	48-51
23369617-0	2012	Modeling Caspian Sea water level oscillations under different scenarios of increasing atmospheric carbon dioxide concentrations.	Water	21-26	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	17-20
23369617-3	2012	Variations in environmental parameters such as temperature, precipitation, evaporation, atmospheric carbon dioxide and water level oscillations of the Caspian sea and surrounding regions, are considered for both past (1951-2006) and future (2025-2100) time frames.	Water	119-124	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	159-162
23369617-7	2012	The Caspian Sea water level has increased by ca.	Water	16-21	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	12-15
22137911-6	2012	PrlR mRNA was significantly higher when fish were transferred to the ion-poor water and GHR1 mRNA was elevated during the saltwater challenge.	Water	78-83	prolactin receptor a	Oncorhynchus mykiss	0-4
23369617-14	2012	Finally, statistical modeling of the Caspian Sea water levels project future water level increases of between 86 cm and 163 cm by the years 2075 and 2100, respectively.	Water	49-54	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	45-48
23369617-14	2012	Finally, statistical modeling of the Caspian Sea water levels project future water level increases of between 86 cm and 163 cm by the years 2075 and 2100, respectively.	Water	77-82	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	45-48
22155714-5	2012	We show that treatment of a microglial BV2 cell line with hydrogen peroxide (H(2)O(2)) stimulates ATX expression and LPA production.	Water	77-83	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	98-101
32300112-5	2020	Here, we investigate the continuous shift in coastal flooding regimes by quantifying continuous rates of increase in the occurrence of extreme water-level events due to sea-level rise.	Water	143-148	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	169-172
32300112-6	2020	We find that the odds of exceeding critical water-level thresholds increases exponentially with sea-level rise, meaning that fixed amounts of sea-level rise of only ~1-10 cm in areas with a narrow range of present-day extreme water levels can double the odds of flooding.	Water	44-49	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	96-99
22132686-5	2012	Through (31)P NMR investigations it was identified that the combination of ArB(OH)(2), KF, and water triggers the conversion of the precatalyst to Pd(PtBu(3))(2) and, most likely, Pd-black as a competing side process, explaining the incomplete conversions of aryl chlorides in Suzuki cross-coupling reactions under Pd(I) dimer conditions.	Water	95-100	peptidyl arginine deiminase 1	Homo sapiens	315-320
32300112-6	2020	We find that the odds of exceeding critical water-level thresholds increases exponentially with sea-level rise, meaning that fixed amounts of sea-level rise of only ~1-10 cm in areas with a narrow range of present-day extreme water levels can double the odds of flooding.	Water	44-49	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	142-145
32300112-6	2020	We find that the odds of exceeding critical water-level thresholds increases exponentially with sea-level rise, meaning that fixed amounts of sea-level rise of only ~1-10 cm in areas with a narrow range of present-day extreme water levels can double the odds of flooding.	Water	226-231	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	96-99
23161907-4	2012	Our findings illustrate that although both HLA-B*57 subtypes display the epitope in structurally conserved formats, the impact of their polymorphic differences occurs directly as a consequence of TCR ligation, primarily because of peptide adjustments required for TCR binding, which involves the interplay of polymorphic residues and water molecules.	Water	334-339	major histocompatibility complex, class I, B	Homo sapiens	43-48
32300112-6	2020	We find that the odds of exceeding critical water-level thresholds increases exponentially with sea-level rise, meaning that fixed amounts of sea-level rise of only ~1-10 cm in areas with a narrow range of present-day extreme water levels can double the odds of flooding.	Water	226-231	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	142-145
23161907-4	2012	Our findings illustrate that although both HLA-B*57 subtypes display the epitope in structurally conserved formats, the impact of their polymorphic differences occurs directly as a consequence of TCR ligation, primarily because of peptide adjustments required for TCR binding, which involves the interplay of polymorphic residues and water molecules.	Water	334-339	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	196-199
23247142-2	2012	Floods, droughts, heavy storms, changes in rain pattern, increase of temperature and sea level, they all show an increasing  trend worldwide and will affect biological, physical and chemical components of water through different paths thus enhancing the  risk of waterborne diseases.	Water	205-210	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
33056848-2	2020	nov., a new species of the water scavenger beetle (Hydrophilidae: Acidocerinae) is described and illustrated, based on adult males, collected in the Lower Parnaiba River Basin, north of Piaui, Northeast Region of Brazil.	Water	27-32	cellular communication network factor 3	Homo sapiens	0-4
23369363-8	2012	Thus, this study concluded that receptor modeling of APCS-ANN can be used to solve various constraints in environmental problem that exist between water distribution variables toward appropriate water quality management.	Water	147-152	amyloid P component, serum	Homo sapiens	53-57
23369363-8	2012	Thus, this study concluded that receptor modeling of APCS-ANN can be used to solve various constraints in environmental problem that exist between water distribution variables toward appropriate water quality management.	Water	195-200	amyloid P component, serum	Homo sapiens	53-57
32295360-1	2020	When a dilute aqueous solution freezes at 1 atm, it is segregated into water-rich ice Ih and solute-rich freeze-concentrated glassy solution.	Water	71-76	ATM serine/threonine kinase	Homo sapiens	44-47
23041062-2	2012	In cultured mesothelial cells, glucose up-regulates AQP3, which may be important for water transport through the peritoneal membrane.	Water	85-90	aquaporin 3 (Gill blood group)	Rattus norvegicus	52-56
21959772-4	2012	Mice that express a constitutively active Signal Transducer and Activator of Transcription 6 (STAT6VT) have increased Th2 cells and a predisposition to allergic inflammation were used in these studies, they demonstrate that topical treatment with the irritant sodium lauryl sulfate (SLS) caused increased transepidermal water loss and epidermal thickening in STAT6VT mice over similarly treated wild-type mice.	Water	320-325	heart and neural crest derivatives expressed 2	Mus musculus	118-121
32202754-5	2020	In-depth analysis suggests that the improved HER activity of Au/CoP@NC-3 is attributed to the presence of Au nanoparticles, which enlarge the electrochemical active surface areas, and adjust the electronic structure of active CoP species to enhance the water adsorption and optimize the H adsorption for accelerated HER process.	Water	253-258	caspase recruitment domain family member 16	Homo sapiens	64-67
23282142-7	2012	RESULTS: Twenty two of the top-ranked water-soluble compounds were selected for inhibitory screening against PAD4.	Water	38-43	peptidyl arginine deiminase 4	Homo sapiens	109-113
23204928-8	2012	In negative mode as well, the maximum number of MS2 features was detected in methanol/chloroform/water and acetone/isopropanol extracts.	Water	97-102	MS2	Homo sapiens	48-51
22427315-2	2012	Binding of AVP to the arginine vasopressin receptor type 2 (AVPR2) in the basolateral membrane leads to translocation of aquaporin 2 (AQP2) water channels to the apical membrane of the collecting duct principal cells, inducing water permeability of the membrane.	Water	140-145	aquaporin 2	Homo sapiens	121-132
22253100-3	2012	We suggest that "insoluble black HCN polymers" are formed by an unsaturated complex matrix, which retains a significant amount of H(2) O and important bioorganic compounds or their precursors.	Water	130-136	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	33-36
32202754-5	2020	In-depth analysis suggests that the improved HER activity of Au/CoP@NC-3 is attributed to the presence of Au nanoparticles, which enlarge the electrochemical active surface areas, and adjust the electronic structure of active CoP species to enhance the water adsorption and optimize the H adsorption for accelerated HER process.	Water	253-258	caspase recruitment domain family member 16	Homo sapiens	226-229
22427315-2	2012	Binding of AVP to the arginine vasopressin receptor type 2 (AVPR2) in the basolateral membrane leads to translocation of aquaporin 2 (AQP2) water channels to the apical membrane of the collecting duct principal cells, inducing water permeability of the membrane.	Water	140-145	aquaporin 2	Homo sapiens	134-138
22427315-2	2012	Binding of AVP to the arginine vasopressin receptor type 2 (AVPR2) in the basolateral membrane leads to translocation of aquaporin 2 (AQP2) water channels to the apical membrane of the collecting duct principal cells, inducing water permeability of the membrane.	Water	227-232	aquaporin 2	Homo sapiens	121-132
22427315-2	2012	Binding of AVP to the arginine vasopressin receptor type 2 (AVPR2) in the basolateral membrane leads to translocation of aquaporin 2 (AQP2) water channels to the apical membrane of the collecting duct principal cells, inducing water permeability of the membrane.	Water	227-232	aquaporin 2	Homo sapiens	134-138
22942646-6	2012	RESULTS: TAA/DA-Chit nanoparticles were prepared with a TAA-loading capacity in the range of 12%-82%, which increased the water solubility of TAA from 0.3 mg/mL to 2.1 mg/mL.	Water	122-127	chitinase 1	Homo sapiens	16-20
32131591-7	2020	e-Fold times, tau1/e, in water-rich solvent mixtures range from tau1/e = 15-45 min for monoterpene-derived alpha-HHs to tau1/e > 103 min for the alpha-Tp-derived alpha-HH.	Water	25-30	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	107-115
22352384-20	2012	As a consequence of the prevailing reduction of (32)S and reverse-diffusion of sulphate into the open sea water, a (32)S enrichment takes place in the uppermost layer of the sediment.	Water	106-111	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	102-105
23018093-0	2012	Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.	Water	20-25	heat shock protein 90 alpha family class A member 1	Homo sapiens	86-91
32131591-9	2020	Decay rates of the alpha-Tp-derived alpha-HH in pure water increase at lower pH (2.3 <= pH <= 3.3).	Water	53-58	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	36-44
23018093-3	2012	Ligand-Hsp90 X-ray structures combined with molecular modeling led to the rational displacement of a conserved water molecule leading to enhanced affinity for Hsp90 as measured by fluorescence polarization, isothermal titration calorimetry and surface plasmon resonance assays.	Water	111-116	heat shock protein 90 alpha family class A member 1	Homo sapiens	7-12
23018093-3	2012	Ligand-Hsp90 X-ray structures combined with molecular modeling led to the rational displacement of a conserved water molecule leading to enhanced affinity for Hsp90 as measured by fluorescence polarization, isothermal titration calorimetry and surface plasmon resonance assays.	Water	111-116	heat shock protein 90 alpha family class A member 1	Homo sapiens	159-164
32176501-7	2020	The results from this work may provide useful information for the preparation of metal@Cu2O water-based suspensions which are expected to be used for the SERS, photocatalyst or photothermal applications.	Water	92-97	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	154-158
23018093-7	2012	This work demonstrates the power of structure-based design for the rapid evolution of potent Hsp90 inhibitors and the importance of considering conserved water molecules in drug design.	Water	154-159	heat shock protein 90 alpha family class A member 1	Homo sapiens	93-98
22334793-11	2012	This GM-CSF effect cannot be achieved by administering the drug via the IV route because the drug is water-soluble and too large to penetrate the alveolocapillary membrane.	Water	101-106	colony stimulating factor 2	Homo sapiens	5-11
32308262-0	2020	Molecular dynamics analysis of conserved water mediated inter-domain recognition of His667-Trp669 in human ceruloplasmin.	Water	41-46	ceruloplasmin	Homo sapiens	107-120
22879979-16	2012	Overexpression of HO-1 prevented the toxic effect induced by H(2)O(2) and NOC-18.	Water	61-66	heme oxygenase 1	Homo sapiens	18-22
22765982-8	2012	In this study, female rats drink NP water during pregnancy and lactation conferred F(1) generation: (1) increase the corticosterone, aldosterone concentration in plasma; (2) increase 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity in liver and adipose tissue; (3) increase aldosterone synthase activity in adrenal for adult offspring.	Water	36-41	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	291-311
22679498-0	2012	Microbial and chemical characterization of underwater fresh water springs in the Dead Sea.	Water	48-53	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	86-89
32280888-0	2020	Study on Water Displacing Gas Relative Permeability Curves in Fractured Tight Sandstone Reservoirs Under High Pressure and High Temperature.	Water	9-14	gastrin	Homo sapiens	26-29
22679498-10	2012	Analysis of the water"s chemistry shows evidence of microbial activity along the path and suggests that the springs supply nitrogen, phosphorus and organic matter to the microbial communities in the Dead Sea.	Water	16-21	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	204-207
32280888-1	2020	Water-gas relative permeability is an important parameter for the rational development of gas fields.	Water	0-5	gastrin	Homo sapiens	6-9
23135470-11	2012	Hence, routing of surface melt water into filling the pore space of the firn column will delay expansion of the area contributing to sea-level rise, although once the pore space is filled it cannot quickly be regenerated.	Water	31-36	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	133-136
32280888-1	2020	Water-gas relative permeability is an important parameter for the rational development of gas fields.	Water	0-5	gastrin	Homo sapiens	90-93
22715407-1	2012	Aquaporin-5 (AQP5) is a water-specific channel located on the apical surface of airway epithelial cells.	Water	24-29	aquaporin 5	Homo sapiens	0-11
32280888-3	2020	The water displacing gas process in fractured tight sandstone reservoirs, under formation condition (116 MPa and 160  C), was simulated by the self-manufactured displacing apparatus.	Water	4-9	gastrin	Homo sapiens	21-24
22715407-1	2012	Aquaporin-5 (AQP5) is a water-specific channel located on the apical surface of airway epithelial cells.	Water	24-29	aquaporin 5	Homo sapiens	13-17
22782339-10	2012	Plvap(-/-) mice provide an animal model to clarify the specific functional role of endothelial fenestrae and their contribution to passage of water and solutes in different organs.	Water	142-147	plasmalemma vesicle associated protein	Mus musculus	0-5
32087576-4	2020	AtTSPO reduces water loss by depleting aquaporin PIP2;7 in the plasma membrane.	Water	15-20	TSPO(outer membrane tryptophan-rich sensory protein)-like protein	Arabidopsis thaliana	0-6
23209334-0	2012	Function of the membrane water channel aquaporin-5 in the salivary gland.	Water	25-30	aquaporin 5	Homo sapiens	39-50
22493723-2	2012	Potassium kinetics can be modulated by aquaporin-4 (AQP4), the essential water channel for astrocyte water permeability regulation.	Water	73-78	aquaporin 4	Rattus norvegicus	39-50
22493723-2	2012	Potassium kinetics can be modulated by aquaporin-4 (AQP4), the essential water channel for astrocyte water permeability regulation.	Water	73-78	aquaporin 4	Rattus norvegicus	52-56
32210322-0	2020	Towards visible light driven photoelectrocatalysis for water treatment: Application of a FTO/BiVO4/Ag2S heterojunction anode for the removal of emerging pharmaceutical pollutants.	Water	55-60	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	89-92
32164329-1	2020	Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2).	Water	39-44	aquaporin 2	Homo sapiens	125-150
22116702-1	2012	Riboflavin (7,8-dimethyl-10-ribitylisoalloxazine; vitamin B2) is a water-soluble vitamin, cofactor derivatives of which (FAD, FMN) act as electron acceptors in the oxidative metabolism of carbohydrate, amino acids and fatty acids and which in the reduced state can donate electrons to complex II of the electron transport chain.	Water	67-72	formin 1	Homo sapiens	126-129
22828295-4	2012	Organic matter in the water matrix highly influenced the removal of the tested bacteriophages MS2 and phiX174.	Water	22-27	MS2	Homo sapiens	94-97
23098648-3	2012	In Dictyostelium, genetic studies show that hydroxylation of Skp1 by PhyA, and subsequent glycosylation of the hydroxyproline, is required for normal oxygen sensing during multicellular development at an air/water interface.	Water	208-213	S-phase kinase associated protein 1	Homo sapiens	61-65
23762616-2	2012	Aquaporin 5 plays an important role in maintaining inner ear water and fluid homeostasis.	Water	61-66	aquaporin 5	Homo sapiens	0-11
32164329-1	2020	Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2).	Water	39-44	aquaporin 2	Homo sapiens	152-156
22282586-6	2011	These results suggest the following possibilities: 1) FS cells especially require water for their functions and 2) transepithelial water transfer could occur between the lumen of Rathke"s residual pouch and the interstitial fluid in the adenohypophysis through the AQP4 and AQP5 channels in the marginal layer cells.	Water	131-136	aquaporin 4	Rattus norvegicus	265-269
32164329-3	2020	The cAMP activates protein kinase A (PKA), which initiates signaling that causes an accumulation of AQP2 in the plasma membrane of the cells facilitating water reabsorption from primary urine and fine-tuning of body water homeostasis.	Water	154-159	aquaporin 2	Homo sapiens	100-104
32608622-4	2020	The results show that:(1) The retrieval model established by the ratio of the sixth band to the third band of the MSI sensor is suitable for high-turbidity water type, with high accuracy (R2=0.863, RMSE=22.211 mg L-1).	Water	156-161	RB binding protein 4, chromatin remodeling factor	Homo sapiens	114-117
22029424-4	2011	The aggregation of the DAO headgroup leads to well-defined H-aggregates at the air/water interface for those mixed monolayers with a low content of DAO.	Water	83-88	D-amino acid oxidase	Homo sapiens	23-26
32143612-10	2020	Compared with caffeine-damaged cells, cells pretreated with neferine, or alcohol or water extract of lianzixin showed a notable increase in nucleus staining and an obvious decrease in cleaved PARP expression.	Water	84-89	poly (ADP-ribose) polymerase 1	Rattus norvegicus	192-196
23155673-4	2012	We report a case of possible intravascular distal embolization of water-soluble PEG polymer that is deployed extravascular using the Mynx vascular closure device.	Water	66-71	progestagen associated endometrial protein	Homo sapiens	80-83
22170684-1	2011	The Messinian salinity crisis (5.96 to 5.33 million years ago) was caused by reduced water inflow from the Atlantic Ocean to the Mediterranean Sea resulting in widespread salt precipitation and a decrease in Mediterranean sea level of about 1.5 kilometres due to evaporation.	Water	85-90	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	143-146
31866008-6	2020	Meanwhile, PDPN expression could be induced by trauma-related stimuli, such as lipopolysaccharide (LPS), ATP, H2O2 and hemoglobin (Hb), in primary microglia.	Water	110-114	podoplanin	Mus musculus	11-15
22170684-1	2011	The Messinian salinity crisis (5.96 to 5.33 million years ago) was caused by reduced water inflow from the Atlantic Ocean to the Mediterranean Sea resulting in widespread salt precipitation and a decrease in Mediterranean sea level of about 1.5 kilometres due to evaporation.	Water	85-90	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	222-225
22170684-2	2011	The reduced connectivity between the Atlantic and the Mediterranean at the time of the salinity crisis is thought to have resulted from tectonic uplift of the Gibraltar arc seaway and global sea-level changes, both of which control the inflow of water required to compensate for the hydrological deficit of the Mediterranean.	Water	246-251	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	173-176
21360171-2	2011	The accurate quantum-chemical computations based on the density functional theory (DFT) and ab initio second-order Moller-Plesset perturbation method (MP2) have been performed for the first time to study interactions of trans-resveratrol with guanine-thymine dinucleotide and DNA-derived nitrogenous bases: adenine, guanine, cytosine and thymine in vacuum and water medium.	Water	360-365	tryptase pseudogene 1	Homo sapiens	151-154
22882482-10	2012	Our data suggest that water metabolism through AQP3 is maintained during neoplastic transformation in most human tissues.	Water	22-27	aquaporin 3 (Gill blood group)	Homo sapiens	47-51
21985312-5	2012	Indeed, for one particular cholinium-based derivative, its water solubility is improved more than 100 times and the half maximal inhibitory concentration (IC(50)) value (22 mug mL(-1)) was one-third that of wide-type betulinic acid (60 mug mL(-1)).	Water	59-64	L1 cell adhesion molecule	Mus musculus	177-183
21985312-5	2012	Indeed, for one particular cholinium-based derivative, its water solubility is improved more than 100 times and the half maximal inhibitory concentration (IC(50)) value (22 mug mL(-1)) was one-third that of wide-type betulinic acid (60 mug mL(-1)).	Water	59-64	L1 cell adhesion molecule	Mus musculus	240-246
31913697-6	2020	To more directly test this, mice deficient in Olfr-78 were administered with DSS in water for 7 days and were found to have increased expression of IL-1beta and inflammatory signs in colon compared with control mice.	Water	84-89	olfactory receptor family 51 subfamily E member 2	Mus musculus	46-53
22676888-2	2012	Aquaporin-4 (AQP4) plays an important role in water transport in the central nervous system and is highly expressed in brain astrocytes.	Water	46-51	aquaporin 4	Rattus norvegicus	0-11
22676888-2	2012	Aquaporin-4 (AQP4) plays an important role in water transport in the central nervous system and is highly expressed in brain astrocytes.	Water	46-51	aquaporin 4	Rattus norvegicus	13-17
21958704-6	2011	A sharp increase of JcHSP-2 transcripts occurred in response to water content dropping from 42% in mature seeds to 12% in dry seeds.	Water	64-69	17.3 kDa class I heat shock protein-like	Jatropha curcas	20-27
21999364-8	2011	The average sequential water molecule binding energies for TrpH(+)(H(2)O)(n) and a doubly protonated tripeptide, [KYK + 2H](2+)(H(2)O)(n), approach asymptotic values of ~9.3 (n &gt;= 11) and ~10.0 kcal/mol (n &gt;= 25), respectively, consistent with a liquidlike structure of water in these nanodrops.	Water	23-28	tryptophan hydroxylase 1	Homo sapiens	59-63
31913697-6	2020	To more directly test this, mice deficient in Olfr-78 were administered with DSS in water for 7 days and were found to have increased expression of IL-1beta and inflammatory signs in colon compared with control mice.	Water	84-89	interleukin 1 alpha	Mus musculus	148-156
31896068-11	2020	The expression of miR-200a was upregulated both in the peri-infarcted region of mice myocardium and H2O2-treated cardiomyocytes.	Water	100-104	microRNA 200a	Mus musculus	18-26
22072674-4	2011	Also morphine improves the spatial memory performance in rats infected by iAbeta packaged virus and in APP/PS1 mice in Morris water maze tests.	Water	126-131	presenilin 1	Rattus norvegicus	107-110
22429860-4	2012	Epidermal growth factor-impregnated bandage contact lenses (created through passive transfer of epidermal growth factor into hydrogel contact lenses of high water content) were used to passively release epidermal growth factor to the corneal surface of the damaged eye.	Water	157-162	epidermal growth factor	Homo sapiens	0-23
22738232-8	2012	The bla(CTX-M-9) group was more prevalent in E. coli isolates from the hospital sewage samples and the bla(CTX-M-1) group was more prevalent in the well-water samples.	Water	153-158	CTX-M-1	Escherichia coli	107-114
21224019-3	2011	In addition to carry out racemization, SR alpha,beta-eliminates water from l- or d-serine, generating pyruvate and NH(4)(+).	Water	64-69	macrophage scavenger receptor 1	Homo sapiens	39-47
31302751-1	2020	The water channel aquaporin 2 (AQP2) is responsible for water reabsorption by kidney collecting duct cells.	Water	4-9	aquaporin 2	Homo sapiens	31-35
21839658-2	2011	On the first reaction route, one water molecule performs nucleophilic attack at the phosphorus center P(gamma) from ATP while the second water molecule in the closed protein cleft serves as a catalytic base assisted by the Glu residue from the myosin salt bridge.	Water	33-38	myosin heavy chain 14	Homo sapiens	244-250
21839658-2	2011	On the first reaction route, one water molecule performs nucleophilic attack at the phosphorus center P(gamma) from ATP while the second water molecule in the closed protein cleft serves as a catalytic base assisted by the Glu residue from the myosin salt bridge.	Water	137-142	myosin heavy chain 14	Homo sapiens	244-250
31978734-4	2020	The results show that filter use without cleaning resulted in biofilm growth and MS2 LRV values increased with increasing feed water nutrient content.	Water	127-132	MS2	Homo sapiens	81-84
21858457-0	2011	Fluvastatin modulates renal water reabsorption in vivo through increased AQP2 availability at the apical plasma membrane of collecting duct cells.	Water	28-33	aquaporin 2	Mus musculus	73-77
21858457-2	2011	The lack of functional V2Rs prevents vasopressin-induced shuttling of aquaporin-2 (AQP2) water channels to the apical plasma membrane of kidney collecting duct principal cells, thus promoting water reabsorption from urine to the interstitium.	Water	89-94	aquaporin 2	Mus musculus	70-81
21858457-2	2011	The lack of functional V2Rs prevents vasopressin-induced shuttling of aquaporin-2 (AQP2) water channels to the apical plasma membrane of kidney collecting duct principal cells, thus promoting water reabsorption from urine to the interstitium.	Water	89-94	aquaporin 2	Mus musculus	83-87
21858457-2	2011	The lack of functional V2Rs prevents vasopressin-induced shuttling of aquaporin-2 (AQP2) water channels to the apical plasma membrane of kidney collecting duct principal cells, thus promoting water reabsorption from urine to the interstitium.	Water	192-197	aquaporin 2	Mus musculus	70-81
21858457-2	2011	The lack of functional V2Rs prevents vasopressin-induced shuttling of aquaporin-2 (AQP2) water channels to the apical plasma membrane of kidney collecting duct principal cells, thus promoting water reabsorption from urine to the interstitium.	Water	192-197	aquaporin 2	Mus musculus	83-87
21896864-8	2011	RESULTS: Expression of Notch1, 2, 4, and Dll4 in the eye were upregulated by EAU induction.	Water	77-80	notch 1	Mus musculus	23-29
21788031-0	2011	Optimization of Co2+ ions removal from water solutions via polymer enhanced ultrafiltration with application of PVA and sulfonated PVA as complexing agents.	Water	39-44	complement C2	Homo sapiens	16-19
22038315-4	2012	Leptin levels significantly increased immediately after WWB with tap water and ISCO(2) (both P &lt; 0.05), and remained significantly higher than those at baseline even 30 minutes after WWB with tap water (P &lt; 0.05).	Water	199-204	leptin	Homo sapiens	0-6
22735908-0	2012	Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development             and healing of water immersion and restraint stress-induced gastric ulcers in             rats.	Water	98-103	insulin-like growth factor 1	Rattus norvegicus	14-19
22735908-1	2012	Insulin-like growth factor 1 (IGF-1) and Akt [also known as protein kinase B (PKB)] proteins have been reported to exhibit gastroprotective effects by reducing water immersion and restraint stress (WRS)-induced gastric mucosal cellular apoptosis.	Water	160-165	insulin-like growth factor 1	Rattus norvegicus	0-28
22735908-1	2012	Insulin-like growth factor 1 (IGF-1) and Akt [also known as protein kinase B (PKB)] proteins have been reported to exhibit gastroprotective effects by reducing water immersion and restraint stress (WRS)-induced gastric mucosal cellular apoptosis.	Water	160-165	insulin-like growth factor 1	Rattus norvegicus	30-35
23252300-0	2012	[Study effect of water extract of ant on anti-fatigue].	Water	17-22	solute carrier family 25 member 6	Homo sapiens	34-37
22773845-8	2012	The binding of the Ser-AMP analog to MST1 induces conformational changes in the aminoacylation active site, and it positions a potential hydrolytic water molecule more favorably for nucleophilic attack.	Water	148-153	threonine--tRNA ligase MST1	Saccharomyces cerevisiae S288C	37-41
22773845-10	2012	In conclusion, we propose that the plasticity of the aminoacylation site in MST1 allows binding of Ser-AMP and the appropriate positioning of the hydrolytic water molecule.	Water	157-162	threonine--tRNA ligase MST1	Saccharomyces cerevisiae S288C	76-80
26295779-0	2012	Facilitating Minima Search for Large Water Clusters at the MP2 Level via Molecular Tailoring.	Water	37-42	tryptase pseudogene 1	Homo sapiens	59-62
26295779-1	2012	Water clusters (H2O)20 and (H2O)25 are explored at the Moller-Plesset second-order perturbation (MP2) level of theory.	Water	0-5	tryptase pseudogene 1	Homo sapiens	97-100
23156770-0	2012	[Self-assembled film of gold nanoparticles at a air/water interface used as a SERS substrate to detect melamine].	Water	52-57	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	78-82
22805117-5	2012	Mozart for H(2)O(2) and its scavenging enzymes catalase (CAT) and ascorbate peroxidase (APX) during leaf and plant development.	Water	11-16	peroxidase A2	Brassica napus	76-86
22744229-2	2012	Regulated water excretion is controlled by various hormones and signaling molecules, with the antidiuretic hormone arginine vasopressin (AVP) playing an essential role, predominantly via its modulatory effects on the function of the water channel aquaporin-2 (AQP2).	Water	10-15	aquaporin 2	Homo sapiens	233-258
22720716-6	2012	SANS experiments show a continuous increase of the size of the structural units with increasing water content.	Water	96-101	USH1 protein network component sans	Homo sapiens	0-4
22621968-3	2012	We trained and tested water-restricted T1R2 knockout (KO), T1R3 KO and their wild-type (WT) same-sex littermate controls in a two-response operant procedure to sample a fluid and differentially respond on the basis of whether the stimulus was water or a tastant.	Water	22-27	taste receptor, type 1, member 2	Mus musculus	39-43
22797694-3	2012	When we ran a spatial discrimination water maze task using two visually identical beacons, Grin1(DeltaDGCA1) mice were impaired at using spatial information to inhibit selecting the decoy beacon, despite knowing the platform"s actual spatial location.	Water	37-42	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	91-96
22639078-9	2012	The HSP90 subset from real life fragment optimization programs revealed that Glide is able to reproduce the positions of multiple bound fragments if conserved water molecules are considered.	Water	159-164	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9
22671299-2	2012	We report the facile and chemoselective reaction of tyrosine-containing G-protein-coupled receptor (GPCR) peptides with [Cp*Rh(H(2)O)(3)](OTf)(2), in water, at room temperature, and at pH 5-6.	Water	150-155	C-X-C motif chemokine receptor 6	Homo sapiens	72-98
22671299-2	2012	We report the facile and chemoselective reaction of tyrosine-containing G-protein-coupled receptor (GPCR) peptides with [Cp*Rh(H(2)O)(3)](OTf)(2), in water, at room temperature, and at pH 5-6.	Water	150-155	C-X-C motif chemokine receptor 6	Homo sapiens	100-104
22535216-1	2012	The interaction of a water molecule with the (100) surface of MgO as described by cluster models is studied using MP2, coupled MP2 (MP2C) and symmetry-adapted perturbation theory (SAPT) methods.	Water	21-26	tryptase pseudogene 1	Homo sapiens	114-130
26069764-2	2012	Patients with congenital NDI bearing mutations in the vasopressin 2 receptor gene, AVPR2, or in the aquaporin-2 gene, AQP2, have a pure NDI phenotype with loss of water but normal conservation of sodium, potassium, chloride and calcium.	Water	163-168	aquaporin 2	Homo sapiens	100-111
26069764-2	2012	Patients with congenital NDI bearing mutations in the vasopressin 2 receptor gene, AVPR2, or in the aquaporin-2 gene, AQP2, have a pure NDI phenotype with loss of water but normal conservation of sodium, potassium, chloride and calcium.	Water	163-168	aquaporin 2	Homo sapiens	118-122
22424766-0	2012	One-step synthesis and assembly of one-dimensional parallel chains of CdS nanoparticles at the air-water interface templated by 10,12-pentacosadiynoic acid supermolecules.	Water	99-104	CDP-diacylglycerol synthase 1	Homo sapiens	70-73
22424766-1	2012	Regular one-dimensional (1D) parallel chains composed of CdS nanoparticles with cubic zinc blende crystal structure were prepared at the air/water interface via one-step synthesis and assembly process.	Water	141-146	CDP-diacylglycerol synthase 1	Homo sapiens	57-60
22717749-1	2012	Granular activated carbon (GAC) is an alternative filter substrate for municipal water treatment as it provides a high surface area suitable for microbial colonization.	Water	81-86	glutaminase	Homo sapiens	27-30
22691352-9	2012	RESULTS: Acute immobilization and cold water-immersion stress reduced IL-2 level,  and increased IL-6 and TNF-alpha level at different time points (0,  30,  60 and 120 min) after stress,  which was most obvious at 30 min.	Water	39-44	interleukin 2	Rattus norvegicus	70-74
22691352-10	2012	Oral administration (gavage) of compound nutrients was found to moderate the acute immobilization and cold water-immersion stress-induced changes in serum IL-2,  IL-6 and TNF-alpha,  which was also most significant at 30 min after stress.	Water	107-112	interleukin 2	Rattus norvegicus	155-159
22559201-7	2012	We then figured out how the two binding mechanisms can coexist: the enthalpy (due to electrostatic interaction between actin and myosin) provides the basal binding affinity, and the entropy (due to the orientational disorder of water molecules) enhances it at higher temperatures.	Water	228-233	myosin heavy chain 14	Homo sapiens	129-135
22357920-1	2012	Collecting duct (CD) endothelin-1 (ET-1) is an important autocrine inhibitor of Na and water transport.	Water	87-92	endothelin 1	Mus musculus	21-33
22357920-1	2012	Collecting duct (CD) endothelin-1 (ET-1) is an important autocrine inhibitor of Na and water transport.	Water	87-92	endothelin 1	Mus musculus	35-39
22460710-3	2012	The antidiuretic hormone vasopressin (VP) and its receptor, the V2R, play a central role in regulating the urinary concentrating mechanism by stimulating accumulation of the aquaporin 2 (AQP2) water channel in the apical membrane of collecting duct principal cells.	Water	193-198	aquaporin 2	Homo sapiens	174-185
22460710-3	2012	The antidiuretic hormone vasopressin (VP) and its receptor, the V2R, play a central role in regulating the urinary concentrating mechanism by stimulating accumulation of the aquaporin 2 (AQP2) water channel in the apical membrane of collecting duct principal cells.	Water	193-198	aquaporin 2	Homo sapiens	187-191
22828224-0	2012	[Ingestion of sea water as cause of hypernatriemia and rhabdomyolysis in African migrants arriving in Lampedusa through the Strait of Sicily].	Water	18-23	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	14-17
22310983-1	2012	Guanylin, a bioactive intestinal peptide, is involved in the cystic fibrosis transmembrane conductance (CFTR)-regulated electrolyte/water secretion in various epithelia.	Water	132-137	CF transmembrane conductance regulator	Rattus norvegicus	104-108
22459924-1	2012	A water-soluble polysaccharide (FUP-1) was obtained from Fritillaria ussuriensis Maxim through warm water extraction, ethanol precipitation, anion-exchange and gel-permeation chromatography.	Water	2-7	BTB (POZ) domain containing 7	Mus musculus	32-37
22459924-1	2012	A water-soluble polysaccharide (FUP-1) was obtained from Fritillaria ussuriensis Maxim through warm water extraction, ethanol precipitation, anion-exchange and gel-permeation chromatography.	Water	100-105	BTB (POZ) domain containing 7	Mus musculus	32-37
32479276-0	2020	Environmental impacts of grey water discharge from ships in the Baltic Sea.	Water	30-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	71-74
32479276-1	2020	Discharge of grey water from ships is today unregulated in most sea areas, including the Baltic Sea.	Water	18-23	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	64-67
22359393-9	2012	The results showed a higher bone formation in the pCPC compared to the water-based CPC after 2 weeks by expression of RUNX-2.	Water	71-76	runt-related transcription factor 2	Oryctolagus cuniculus	118-124
32479276-1	2020	Discharge of grey water from ships is today unregulated in most sea areas, including the Baltic Sea.	Water	18-23	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	96-99
32479276-2	2020	Annually, an estimated 5.5 million m3 grey water is emitted to the Baltic Sea with largest contribution from RoPax (4.25 million m3) and cruise ships (0.65 million m3).	Water	43-48	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	74-77
32479276-6	2020	An environmental risk assessment of contaminants, performed at a shipping lane in the Baltic Sea, showed the risk for adverse effects from grey water to be low.	Water	144-149	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	93-96
22497287-5	2012	We find that the performance of the G4(MP2)-type thermochemical procedures deteriorates with the number of water molecules involved in the catalysis.	Water	107-112	tryptase pseudogene 1	Homo sapiens	39-42
32479276-7	2020	Nitrogen and phosphorus input from grey water contributes to 0.25% of the exceedance of, for the Baltic Sea set, eutrophication target.	Water	40-45	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	104-107
31884156-11	2020	EEM promoted the phosphorylation of IkappaBalpha and p65, suppressed the NF-kappaB activation, and inhibited the levels of pro-inflammatory cytokines such as TNF-alpha, IL-6 and their mRNA levels in H2O2-induced PC12 cells.	Water	199-203	NFKB inhibitor alpha	Rattus norvegicus	36-48
22262484-7	2012	In ADPKD, the larger increase in u-AQP2 and p-AVP in response to saline could reflect an abnormal water absorption in the distal nephron.	Water	98-103	aquaporin 2	Homo sapiens	35-39
32059723-0	2020	Chinese medicine Di-Huang-Yi-Zhi protects PC12 cells from H2O2-induced apoptosis by regulating ROS-ASK1-JNK/p38 MAPK signaling.	Water	58-62	mitogen-activated protein kinase 8	Rattus norvegicus	104-107
22197461-1	2012	The radioactivity along the central thimble hole of a decommissioned heavy water research reactor, TRR, was evaluated using TLD approach.	Water	75-80	TRR	Homo sapiens	99-102
32296050-3	2020	In this study, we built an dual-acting therapeutic strategy using micelles with high stability functionalized with fibronectin-targeting CREKA peptides encapsulating two slightly soluble chemotherapy agents in water, doxorubicin (D) and vinorelbine (V), which we termed C-DVM.	Water	210-215	fibronectin 1	Mus musculus	115-126
33888922-9	2020	Incrementally increasing sea level rise scenarios ranging from 15 cm to 75 cm predicted an exponential decrease in soil pore space available to receive incoming tidal water and an approximately linear increase in inundation frequency of the top 10 cm of soil; this substantial change in hydrology would impact the marsh"s ability to process incoming water and could alter the zonation of vegetation.	Water	167-172	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	25-28
33888922-9	2020	Incrementally increasing sea level rise scenarios ranging from 15 cm to 75 cm predicted an exponential decrease in soil pore space available to receive incoming tidal water and an approximately linear increase in inundation frequency of the top 10 cm of soil; this substantial change in hydrology would impact the marsh"s ability to process incoming water and could alter the zonation of vegetation.	Water	350-355	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	25-28
31869219-0	2020	Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.	Water	0-5	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	48-74
21443951-5	2011	The ability of these low-molecular weight surfactants to inhibit lipid digestion was attributed to a number of potential mechanisms: (i) prevention of lipase/co-lipase adsorption to the oil-water interface; (ii) formation of interfacial complexes; (iii) direct interaction and inactivation of lipase/co-lipase.	Water	190-195	lipase	Zea mays	151-157
21443951-5	2011	The ability of these low-molecular weight surfactants to inhibit lipid digestion was attributed to a number of potential mechanisms: (i) prevention of lipase/co-lipase adsorption to the oil-water interface; (ii) formation of interfacial complexes; (iii) direct interaction and inactivation of lipase/co-lipase.	Water	190-195	lipase	Zea mays	161-167
21443951-5	2011	The ability of these low-molecular weight surfactants to inhibit lipid digestion was attributed to a number of potential mechanisms: (i) prevention of lipase/co-lipase adsorption to the oil-water interface; (ii) formation of interfacial complexes; (iii) direct interaction and inactivation of lipase/co-lipase.	Water	190-195	lipase	Zea mays	161-167
21443951-5	2011	The ability of these low-molecular weight surfactants to inhibit lipid digestion was attributed to a number of potential mechanisms: (i) prevention of lipase/co-lipase adsorption to the oil-water interface; (ii) formation of interfacial complexes; (iii) direct interaction and inactivation of lipase/co-lipase.	Water	190-195	lipase	Zea mays	161-167
31869219-0	2020	Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.	Water	0-5	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	76-80
31869219-5	2020	These tools identified a high-energy path of water molecules connecting the inhibitor binding site with the alphaKG and NADP+ binding sites in mutant IDH1.	Water	45-50	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	150-154
31869219-6	2020	This water path aligns spatially with the alpha10 helix from WT IDH1 crystal structures.	Water	5-10	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	64-68
31869219-7	2020	Mutating residues at the termini of this water path specifically disrupted inhibitor binding and/or D2HG production, revealing additional key residues to consider in optimizing druglike molecules against mutant IDH1.	Water	41-46	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	211-215
22250559-1	2011	Atmospheric correction is a bottleneck in quantitative application of Chinese satellites HJ-1 data to remote sensing of water color.	Water	120-125	jagged canonical Notch ligand 1	Homo sapiens	89-93
32831244-3	2020	In this work, the [AdH]6[V10O28].4(H2O) (1) supramolecular structure is introduced using adenine and decavanadate moieties that allow probing of selectivity to specific nucleic acid binding events by optical changes.	Water	35-38	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	19-22
21960630-0	2011	Evidence of water vapor in excess of saturation in the atmosphere of Mars.	Water	12-17	methionyl-tRNA synthetase 1	Homo sapiens	69-73
31858814-4	2020	METHODS: In primary cardiomyocytes challenged with H2O2, expressions of miR-132-3p, TUG1 and other target proteins were measured by RT-qPCR or Western blot; cell viability by MTT assay; apoptosis by Annexin V and PI staining; the abundance of acetylated H3K9 or histone deacetylase 3 (HDAC3) within the promoter of target genes by chromatin immunoprecipitation; the direct interaction between miR-132-3p and HDAC3 or TUG1 by luciferase reporter assay.	Water	51-55	microRNA 1323	Homo sapiens	72-82
21960630-1	2011	The vertical distribution of water vapor is key to the study of Mars" hydrological cycle.	Water	29-34	methionyl-tRNA synthetase 1	Homo sapiens	64-68
21960630-4	2011	Here, we report observations made using the SPICAM (Spectroscopy for the Investigation of the Characteristics of the Atmosphere of Mars) instrument onboard Mars Express that provide evidence of the frequent presence of water vapor in excess of saturation, by an amount far surpassing that encountered in Earth"s atmosphere.	Water	219-224	methionyl-tRNA synthetase 1	Homo sapiens	131-135
21960630-4	2011	Here, we report observations made using the SPICAM (Spectroscopy for the Investigation of the Characteristics of the Atmosphere of Mars) instrument onboard Mars Express that provide evidence of the frequent presence of water vapor in excess of saturation, by an amount far surpassing that encountered in Earth"s atmosphere.	Water	219-224	methionyl-tRNA synthetase 1	Homo sapiens	156-160
31858814-4	2020	METHODS: In primary cardiomyocytes challenged with H2O2, expressions of miR-132-3p, TUG1 and other target proteins were measured by RT-qPCR or Western blot; cell viability by MTT assay; apoptosis by Annexin V and PI staining; the abundance of acetylated H3K9 or histone deacetylase 3 (HDAC3) within the promoter of target genes by chromatin immunoprecipitation; the direct interaction between miR-132-3p and HDAC3 or TUG1 by luciferase reporter assay.	Water	51-55	annexin A5	Homo sapiens	199-208
21960630-5	2011	This result contradicts the widespread assumption that atmospheric water on Mars cannot exist in a supersaturated state, directly affecting our long-term representation of water transport, accumulation, escape, and chemistry on a global scale.	Water	67-72	methionyl-tRNA synthetase 1	Homo sapiens	76-80
21960630-5	2011	This result contradicts the widespread assumption that atmospheric water on Mars cannot exist in a supersaturated state, directly affecting our long-term representation of water transport, accumulation, escape, and chemistry on a global scale.	Water	172-177	methionyl-tRNA synthetase 1	Homo sapiens	76-80
31858814-4	2020	METHODS: In primary cardiomyocytes challenged with H2O2, expressions of miR-132-3p, TUG1 and other target proteins were measured by RT-qPCR or Western blot; cell viability by MTT assay; apoptosis by Annexin V and PI staining; the abundance of acetylated H3K9 or histone deacetylase 3 (HDAC3) within the promoter of target genes by chromatin immunoprecipitation; the direct interaction between miR-132-3p and HDAC3 or TUG1 by luciferase reporter assay.	Water	51-55	microRNA 1323	Homo sapiens	393-403
31521632-7	2020	Overall, we conclude that AtPIP2;4, SoPIP2;1 and hAQP1 are all transporters of both H2O and H2O2, but have different efficiencies for various specificities.	Water	84-87	plasma membrane intrinsic protein 2;4	Arabidopsis thaliana	26-34
21974533-2	2011	We describe molecular dynamics simulations of a dissociating model for liquid water based on scaling the interatomic potential for water developed by Ojamae-Shavitt-Singer from ab initio studies at the MP2 level.	Water	78-83	tryptase pseudogene 1	Homo sapiens	202-205
31743528-11	2020	Silencing of lncRNA XIST reversed the effect of H2 O2 on miR-124,BACE1 and Abeta1-42 expressionin N2a cells, which was reversed by cotransfection of AMO-124.	Water	48-53	beta-site APP cleaving enzyme 1	Mus musculus	65-70
22321890-11	2011	In addition, the expressions of AQP4 protein and mRNA were positively correlated with brain water content (r = 0.536, P &lt; 0.01; r = 0.566, P = 0.01).	Water	92-97	aquaporin 4	Rattus norvegicus	32-36
21832082-3	2011	The mitochondrial peroxidase peroxiredoxin-3 reduces H(2)O(2) to water using reducing equivalents from NADPH supplied by thioredoxin-2 (Trx2) and, ultimately, thioredoxin reductase-2 (TrxR2).	Water	65-70	thioredoxin 2	Mus musculus	121-134
21832082-3	2011	The mitochondrial peroxidase peroxiredoxin-3 reduces H(2)O(2) to water using reducing equivalents from NADPH supplied by thioredoxin-2 (Trx2) and, ultimately, thioredoxin reductase-2 (TrxR2).	Water	65-70	thioredoxin 2	Mus musculus	136-140
32440656-12	2020	Interestingly, while the likelihood of isolating L. monocytogenes appears to be driven by complex interactions between environmental factors, the likelihood of Salmonella isolation and eaeA-stx codetection were driven by physicochemical water quality (e.g., dissolved oxygen) and temperature, respectively.	Water	237-242	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	190-193
21852741-5	2011	The as-prepared water dispersible ZnSe/CdSe/CdS/Cd(x)Zn(1 - x)S/ZnS core/multishell NCs not only have high fluorescence QYs but also are extremely stable in various physiological conditions.	Water	16-21	CDP-diacylglycerol synthase 1	Homo sapiens	39-42
32082162-2	2019	Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3beta/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes.	Water	0-5	insulin receptor substrate 1	Homo sapiens	77-81
21577093-6	2011	PAI-1-/- mice showed increased excess lung water and elevated cytokines production and release.	Water	43-48	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-5
31964423-13	2020	mRNA and protein analyses of PE-DBMSCs preconditioned with H2O2 at lower doses showed upregulation of HMOX1 expression.	Water	59-63	heme oxygenase 1	Homo sapiens	102-107
21821425-2	2011	In the present study, we determined that Nicotiana tabacum hairy roots (HRs) double transgenic (DT) for two peroxidase genes (tpx1 and tpx2) showed higher phenol removal efficiency than wild type (WT) HRs after 120 h of phenol treatment at the expense of endogenous H(2)O(2).	Water	266-271	peroxidase N1	Nicotiana tabacum	108-118
31849213-7	2020	Results demonstrated that modified NPs were capable of catalyzing H2O2 to produce O2 and eliminate NO, hence inhibiting hypoxia-inducible factor 1alpha (HIF-1alpha) further rescuing mitochondrial function.	Water	66-70	hypoxia inducible factor 1, alpha subunit	Mus musculus	120-151
21788689-3	2011	Patterning processes using scanning probe lithography of graphite or graphene are normally performed in air because water molecules forming the meniscus between the tip and the sample mediate the etching reaction.	Water	116-121	TOR signaling pathway regulator	Homo sapiens	165-168
31849213-7	2020	Results demonstrated that modified NPs were capable of catalyzing H2O2 to produce O2 and eliminate NO, hence inhibiting hypoxia-inducible factor 1alpha (HIF-1alpha) further rescuing mitochondrial function.	Water	66-70	hypoxia inducible factor 1, alpha subunit	Mus musculus	153-163
31435937-9	2020	The water holding capacity of protein hydrolysate was found to be increasing with concentration and value obtained was 5.4 mL g-1 at 20 mg mL-1 concentration.	Water	4-9	L1 cell adhesion molecule	Mus musculus	139-143
21778064-3	2011	Crystallographic and modeling studies suggest that the isatin ring binds to the substrate cavities of MAO-A and -B and is stabilized by hydrogen bond interactions between the NH and the C2 carbonyl oxygen of the dioxoindolyl moiety and water molecules present in the substrate cavities of MAO-A and -B.	Water	236-241	monoamine oxidase A	Homo sapiens	102-114
31820987-0	2020	Formation of Formamide from HCN + H2O: A Computational Study on the Roles of 2ND H2O as a Catalyst, as a Spectator and as a Reactant.	Water	81-84	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	28-31
21768374-1	2011	In the kidney, the actions of vasopressin on its type-2 receptor (V2R) induce increased water reabsorption alongside polyphosphorylation and membrane targeting of the water channel aquaporin-2 (AQP2).	Water	167-172	aquaporin 2	Canis lupus familiaris	181-192
21768374-1	2011	In the kidney, the actions of vasopressin on its type-2 receptor (V2R) induce increased water reabsorption alongside polyphosphorylation and membrane targeting of the water channel aquaporin-2 (AQP2).	Water	167-172	aquaporin 2	Canis lupus familiaris	194-198
31820987-2	2020	In this work, using quantum mechanical computations, reactions between HCN and H2O, leading to the formation of formamide, have been analysed.	Water	79-82	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	71-74
21939115-10	2011	RESULTS: A significant reduction was seen in blood glucose levels among DM patients who were immersed in Dead Sea water.	Water	114-119	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	110-113
21939115-15	2011	CONCLUSION: One-time immersion in Dead Sea water reduces blood glucose levels in type 2 DM patients compared to healthy volunteers.	Water	43-48	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	39-42
31150554-5	2020	DN-DISC1-PrP mice also displayed greater c-fos expression in the insular (gustatory) cortex when consuming water in the presence of the CS.	Water	107-112	FBJ osteosarcoma oncogene	Mus musculus	41-46
22619937-0	2011	[Composition and source of atmosphere aerosol water soluble ions over the East China Sea in winter].	Water	46-51	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
31188544-0	2020	Claudin-15 forms a water channel through the tight junction with distinct function compared to claudin-2.	Water	19-24	claudin-15	Canis lupus familiaris	0-10
21819668-3	2011	A simple rinsing or soaking in water was able to remove &gt;95% of hNoV from surface-inoculated raspberries.	Water	31-36	cellular communication network factor 3	Homo sapiens	67-71
21819668-4	2011	In contrast, only 75% of hNoV was removed from surface-inoculated romaine lettuce by rinsing in tap water.	Water	100-105	cellular communication network factor 3	Homo sapiens	25-29
21120554-5	2011	Interestingly, at the binding sites of all PPI-CYP2C9 complexes except for Lan/CYP2C9, there are hydrogen-bonding networks made of PPIs, water molecules, and some residues of 2C9.	Water	137-142	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	47-53
21120554-5	2011	Interestingly, at the binding sites of all PPI-CYP2C9 complexes except for Lan/CYP2C9, there are hydrogen-bonding networks made of PPIs, water molecules, and some residues of 2C9.	Water	137-142	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	79-85
21605990-7	2011	The effect of hydrating water molecules located between uPA and uPAR is also investigated to be significant for the specific interactions between uPA and uPAR.	Water	24-29	plasminogen activator, urokinase receptor	Homo sapiens	64-68
21605990-7	2011	The effect of hydrating water molecules located between uPA and uPAR is also investigated to be significant for the specific interactions between uPA and uPAR.	Water	24-29	plasminogen activator, urokinase receptor	Homo sapiens	154-158
22103159-0	2011	Preparation of hydrogen titanate nanotube/FTO glass thin film obtained by the layer-by-layer-self assembling method for water splitting.	Water	120-125	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	42-45
21806097-4	2011	Molecular LiF in vacuum and LiF solvated by a single water molecule are examined as model systems.	Water	53-58	LIF interleukin 6 family cytokine	Homo sapiens	10-13
21806106-3	2011	When systematically applied to 40 low-lying (H(2)O)(n) isomers ranging in size from n = 3 to 10, the CCSD(T):MP2 3-body:many-body fragmentation scheme deviates from the full CCSD(T) interaction energy by no more than 0.07 kcal mol(-1) (or &lt;0.01 kcal mol(-1) per water).	Water	265-270	tryptase pseudogene 1	Homo sapiens	109-112
21806106-5	2011	The 3-body:many-body CCSD(T):MP2 procedure is also very efficient because the CCSD(T) computations only need to be performed on subsets of the cluster containing 1, 2, or 3 monomers, which in the current context means the largest CCSD(T) calculations are for 3 water molecules, regardless of the cluster size.	Water	261-266	tryptase pseudogene 1	Homo sapiens	29-32
21806148-3	2011	The maximum depth of the shoulder well is chosen so that the resulting potential reproduces the oxygen-oxygen radial distribution function of the ST4 model of water.	Water	159-164	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	146-149
21625718-2	2011	This reagent could as well be used for selective and quantitative extraction of F(-) from the aqueous solution of NaF and sea water.	Water	126-131	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	122-125
21644504-0	2011	Optimized unlike-pair interactions for water-carbon dioxide mixtures described by the SPC/E and EPM2 models.	Water	39-44	EPM2A glucan phosphatase, laforin	Homo sapiens	96-100
21644504-1	2011	The unlike-pair interaction parameters for the SPC/E-EPM2 models have been optimized to reproduce the mutual solubility of water and carbon dioxide at the conditions of liquid-supercritical fluid phase equilibria.	Water	123-128	EPM2A glucan phosphatase, laforin	Homo sapiens	53-57
21682268-2	2011	In this study we compared the active sites of monomers and tetramers of human BChE and human AChE after performing molecular dynamics (MD) simulations in water-solvated systems.	Water	154-159	butyrylcholinesterase	Homo sapiens	78-82
21525134-2	2011	Importantly, 24-h BUO reduces the abundance of the collecting duct water channel aquaporin-2 (AQP2) and AQP2 phosphorylated at serine 256 (AQP2pS256).	Water	67-72	aquaporin 2	Rattus norvegicus	94-98
21253892-6	2011	The peptide/MHC/TCR interface was found to hold significant number of solvent molecules, more specifically the peptide has been found to have approximately seventeen hydrogen bonds with water molecules.	Water	186-191	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	16-19
21457357-1	2011	Aquaporin 3 (AQP3), a member of the aquaglyceroporin family, which transports water and glycerol, is robustly expressed in epidermis and plays an important role in stratum corneum hydration, permeability barrier function and wound healing.	Water	78-83	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
21457357-1	2011	Aquaporin 3 (AQP3), a member of the aquaglyceroporin family, which transports water and glycerol, is robustly expressed in epidermis and plays an important role in stratum corneum hydration, permeability barrier function and wound healing.	Water	78-83	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
21410273-1	2011	The interaction of a water monomer with a series of linear acenes (benzene, anthracene, pentacene, heptacene, and nonacene) is investigated using a wide range of electronic structure methods, including several "dispersion"-corrected density functional theory (DFT) methods, several variants of the random phase approximation (RPA), DFT-based symmetry-adapted perturbation theory with density fitting (DF-DFT-SAPT), MP2, and coupled-cluster methods.	Water	21-26	tryptase pseudogene 1	Homo sapiens	415-418
21168446-5	2011	In addition, the NEFL(P22S) mice were deficient in the reversal phase of left-right discrimination learning in a water maze.	Water	113-118	neurofilament, light polypeptide	Mus musculus	17-21
21135872-0	2011	Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration.	Water	22-27	aquaporin 3 (Gill blood group)	Homo sapiens	0-10
21429555-0	2011	Effect of municipal waste water effluent upon the expression of Glutathione S-transferase isoenzymes of brine shrimp Artemia.	Water	26-31	glutathione S-transferase kappa 1	Homo sapiens	64-89
21692128-8	2011	In addition, using a porous filter assay, we demonstrate that the egg water protein allurin, in both purified and recombinant forms, stimulates directed motility of sperm.	Water	70-75	cysteine-rich secretory protein 1 gene 8 S homeolog	Xenopus laevis	84-91
21315850-9	2011	Cells in which the AQP5 gene was silenced showed a 49.4% decrease in osmotic water permeability, a 55.3% decrease in migration and a 28.4% decrease in invasion potential.	Water	77-82	aquaporin 5	Homo sapiens	19-23
21315850-11	2011	CONCLUSION: Our results suggest that AQP5, which mediates water permeability and thus regulates cell shape and volume, is a potentially important determinant in cell migration.	Water	58-63	aquaporin 5	Homo sapiens	37-41
21639459-1	2011	The potential of mean force for the dissociation of a Ca-Cl ion pair in water is calculated from ab initio molecular dynamics simulations.	Water	72-77	solute carrier family 25 member 29	Homo sapiens	54-59
21396938-5	2011	Surface pressure measurements of GSL monolayers at the air-water interface allowed us to determine the following order for alpha-synuclein-GSL interactions: GM3&gt;Gb3&gt;GalCer-NFA&gt;GM1&gt;sulfatide&gt;GalCer-HFA&gt;LacCer&gt;GM4&gt;GM2&gt;asialo-GM1&gt;GD3, indicating a marked preference for GSLs with one, three, or five sugar units.	Water	59-64	synuclein alpha	Homo sapiens	123-138
21420942-0	2011	Neuroprotective effects of a novel water-soluble poly(ADP-ribose) polymerase-1 inhibitor, MP-124, in in vitro and in vivo models of cerebral ischemia.	Water	35-40	poly (ADP-ribose) polymerase 1	Rattus norvegicus	49-78
21316381-2	2011	The present study was designed to examine the effects of water- or lipid-soluble (DMSO-soluble) snus and nicotine, the most important substance in tobacco, on the expression of vasocontractile G-protein coupled receptors (GPCR), such as endothelin ET(B), serotonin 5-HT(1B), and thromboxane A(2) TP receptors, in rat cerebral arteries.	Water	57-62	relaxin family peptide receptor 2	Rattus norvegicus	222-226
22162436-3	2012	The degree of swelling (Q) and water uptake (H) in PBS at 37  C are tailorable for PEGDMA co-networks (Q   250-650 vol%), while the storage modulus of swollen networks at 3  C can be adjusted by the PEG(D)MA content (G" = 0.7-145 kPa).	Water	31-36	progestagen associated endometrial protein	Homo sapiens	83-86
22372424-0	2012	Imbibition of soybean seeds in warm water results in the release of copious amounts of Bowman-Birk protease inhibitor, a putative anticarcinogenic agent.	Water	36-41	LOC547785	Glycine max	87-117
22452789-1	2012	BACKGROUND: Dysregulation of the expression/shuttling of the aquaporin-2 water channel (AQP2) and the epithelial sodium channel (ENaC) in renal collecting duct principal cells has been found in animal models of hypertension.	Water	73-78	aquaporin 2	Homo sapiens	61-72
22452789-1	2012	BACKGROUND: Dysregulation of the expression/shuttling of the aquaporin-2 water channel (AQP2) and the epithelial sodium channel (ENaC) in renal collecting duct principal cells has been found in animal models of hypertension.	Water	73-78	aquaporin 2	Homo sapiens	88-92
22308037-7	2012	Two variants were designed to mimic the plant peroxidase active site: D153H, which was more than an order of magnitude less reactive with H(2)O(2), and N246H, which had no detectable peroxidase activity.	Water	138-143	peroxiredoxin	Rhodococcus jostii RHA1	46-56
22366086-4	2012	Genes such as Slc2a5, Cdkn1c, Cabp2, Ranbp3, Vwce and Gcgr were induced by force-feeding with fructose compared with glucose or distilled water.	Water	138-143	RAN binding protein 3	Rattus norvegicus	37-43
22366086-4	2012	Genes such as Slc2a5, Cdkn1c, Cabp2, Ranbp3, Vwce and Gcgr were induced by force-feeding with fructose compared with glucose or distilled water.	Water	138-143	glucagon receptor	Rattus norvegicus	54-58
22305191-3	2012	In this study, the effects of the water extractable fraction of PSP on the metabolism of model CYP1A2, CYP2D6, CYP2E1 and CYP3A4 probe substrates were investigated in pooled human liver microsomes.	Water	34-39	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	95-101
22434701-4	2012	Dialyzed saliva and LPO, in the presence of H(2) O(2) , convert nitrite into nitrate and form some NO, with a molar ratio of 10(3) .	Water	44-50	lactoperoxidase	Bos taurus	20-23
22015945-11	2012	In conclusion, water-suppressed proton ((1)H) MRS provides a non-invasive measure of 2-HG in gliomas, and may serve as a potential biomarker for patients with IDH1 mutant brain tumors.	Water	15-20	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	159-163
22285065-4	2012	Based on these observations, and data from the literature, it is assumed that the source of (129)I in lakes is precipitation and the major source in the Baltic Sea is the inflow of sea water from the North Sea through the Danish Straits.	Water	185-190	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	160-163
22285065-4	2012	Based on these observations, and data from the literature, it is assumed that the source of (129)I in lakes is precipitation and the major source in the Baltic Sea is the inflow of sea water from the North Sea through the Danish Straits.	Water	185-190	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	181-184
22285065-6	2012	In all studied water types the main chemical form of both iodine isotopes was iodide; in sea and lake waters by 92-96% and in rain water by 75-88%.	Water	15-20	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	89-92
22196349-2	2012	After the surface modification, the water contact angle of MEH-PPV is changed from 95.5  to 82.1  without influence on its optical properties (based on the UV and PL spectra), and the water droplet can be absorbed on the modified MEH-PPV surface without sliding even at substrate tilt angles of 90  and 180 .	Water	36-41	epoxide hydrolase 1	Homo sapiens	59-62
22196349-2	2012	After the surface modification, the water contact angle of MEH-PPV is changed from 95.5  to 82.1  without influence on its optical properties (based on the UV and PL spectra), and the water droplet can be absorbed on the modified MEH-PPV surface without sliding even at substrate tilt angles of 90  and 180 .	Water	36-41	epoxide hydrolase 1	Homo sapiens	230-233
22196349-2	2012	After the surface modification, the water contact angle of MEH-PPV is changed from 95.5  to 82.1  without influence on its optical properties (based on the UV and PL spectra), and the water droplet can be absorbed on the modified MEH-PPV surface without sliding even at substrate tilt angles of 90  and 180 .	Water	184-189	epoxide hydrolase 1	Homo sapiens	59-62
22196349-2	2012	After the surface modification, the water contact angle of MEH-PPV is changed from 95.5  to 82.1  without influence on its optical properties (based on the UV and PL spectra), and the water droplet can be absorbed on the modified MEH-PPV surface without sliding even at substrate tilt angles of 90  and 180 .	Water	184-189	epoxide hydrolase 1	Homo sapiens	230-233
22196349-4	2012	In addition, the water transport test indicates that the modified MEH-PPV can be a candidate for transporting water droplet.	Water	17-22	epoxide hydrolase 1	Homo sapiens	66-69
22196349-4	2012	In addition, the water transport test indicates that the modified MEH-PPV can be a candidate for transporting water droplet.	Water	110-115	epoxide hydrolase 1	Homo sapiens	66-69
22260520-4	2012	Thus, a metalloenzyme-inspired polymeric imidazole Pd catalyst (MEPI-Pd) was readily prepared by the coordinative convolution of (NH(4))(2)PdCl(4) and poly[(N-vinylimidazole)-co-(N-isopropylacrylamide)(5)] in a methanol-water solution at 80  C for 30 min.	Water	220-225	serpin family I member 2	Homo sapiens	64-68
22260520-8	2012	Even 0.8-40 mol ppm Pd of MEPI-Pd efficiently promoted allylic arylation/alkenylation/vinylation in alcohol and/or water with a catalytic turnover number (TON) of 20,000-1,250,000.	Water	115-120	serpin family I member 2	Homo sapiens	26-30
22260520-9	2012	Furthermore, MEPI-Pd efficiently promoted the Suzuki-Miyaura reaction of a variety of inactivated aryl chlorides as well as aryl bromides and iodides in water with a TON of up to 3,570,000.	Water	153-158	serpin family I member 2	Homo sapiens	13-17
22320740-2	2012	In this work, the interaction energy of water-pentane dimer has been determined using coupled-cluster theory with single double (triple) excitations [CCSD(T)], 2nd order Moller Plesset perturbation theory (MP2), density fitted local MP2 (DF-LMP2), as well as density functional theory using a wide variety of density functionals and several different basis sets.	Water	40-45	tryptase pseudogene 1	Homo sapiens	206-209
22320740-2	2012	In this work, the interaction energy of water-pentane dimer has been determined using coupled-cluster theory with single double (triple) excitations [CCSD(T)], 2nd order Moller Plesset perturbation theory (MP2), density fitted local MP2 (DF-LMP2), as well as density functional theory using a wide variety of density functionals and several different basis sets.	Water	40-45	tryptase pseudogene 1	Homo sapiens	233-236
21805315-2	2012	A characteristic low ratio of chlorine to bromine, corresponding to that of the Dead Sea water, may serve as an indicator for local production.	Water	89-94	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
21934603-3	2012	We have shown for the first time that a water-soluble extract of taro (TE) potently inhibits lung-colonizing ability and spontaneous metastasis from mammary gland-implanted tumors, in a murine model of highly metastatic estrogen receptor, progesterone receptor and Her-2/neu-negative breast cancer.	Water	40-45	erb-b2 receptor tyrosine kinase 2	Mus musculus	265-270
21934603-3	2012	We have shown for the first time that a water-soluble extract of taro (TE) potently inhibits lung-colonizing ability and spontaneous metastasis from mammary gland-implanted tumors, in a murine model of highly metastatic estrogen receptor, progesterone receptor and Her-2/neu-negative breast cancer.	Water	40-45	erb-b2 receptor tyrosine kinase 2	Mus musculus	271-274
22460465-7	2012	Aquaporin 2 (AQP2) IR also was increased in the renal collecting duct for water re-absorption at HU7 showing a similar pattern with ADH.	Water	74-79	aquaporin 2	Rattus norvegicus	0-11
22460465-7	2012	Aquaporin 2 (AQP2) IR also was increased in the renal collecting duct for water re-absorption at HU7 showing a similar pattern with ADH.	Water	74-79	aquaporin 2	Rattus norvegicus	13-17
22206433-6	2012	The onset potential of the water oxidation current was constant at approximately 1.5 V vs SHE from pH 4 to pH 8, but sharply shifted to negative at pH &gt; 8.	Water	27-32	prolyl 4-hydroxylase, transmembrane	Homo sapiens	99-103
22085681-5	2012	The protein expression level of aquaporin-3 (AQP3), which plays an important role in water transfer, in the coadministration group decreased compared to the control group, as was the case in the bisacodyl group.	Water	85-90	aquaporin 3 (Gill blood group)	Homo sapiens	45-49
22085681-5	2012	The protein expression level of aquaporin-3 (AQP3), which plays an important role in water transfer, in the coadministration group decreased compared to the control group, as was the case in the bisacodyl group.	Water	85-90	aquaporin 3 (Gill blood group)	Homo sapiens	32-43
22139847-6	2012	Accordingly, the loss of p38alpha leads to ROS accumulation in response to H(2)O(2), which causes cell death and inactivation of mTOR/p70S6K signaling.	Water	75-80	ribosomal protein S6 kinase B1	Homo sapiens	134-140
22176527-0	2012	Interfacial viscoelasticity of myoglobin at air/water and air/solution interfaces: role of folding and clustering.	Water	48-53	myoglobin	Homo sapiens	31-40
22142259-0	2012	Co-detoxification of transformer oil-contained PCBs and heavy metals in medical waste incinerator fly ash under sub- and supercritical water.	Water	135-140	transformer	Drosophila melanogaster	21-32
22142259-1	2012	The simultaneous detoxification processes of transformer oil-contained PCBs and heavy metals in medical waste incinerator (MWI) fly ash were developed under sub- and supercritical water.	Water	180-185	transformer	Drosophila melanogaster	45-56
21425816-1	2011	For the first time, a systematic investigation of the glass transition and its related dynamics of myoglobin in water-glycerol solvent mixtures of different water contents is presented.	Water	157-162	myoglobin	Homo sapiens	99-108
21428320-3	2011	In the model case of myoglobin in water, most of the ligands escape; to better observe the geminate phase, high viscosity cosolvents were used: the kinetics were characterized by multiple barriers and a distribution of rates.	Water	34-39	myoglobin	Homo sapiens	21-30
21277313-7	2011	Both AQP1 mutants exhibit a surprising cooperative effect leading to a reduction in the free-energy barrier for proton permeation around the NPA region due to altered water configurations in the SF region, with AQP1-R195S having a higher conductance than AQP1-R195V.	Water	167-172	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	5-9
21277313-7	2011	Both AQP1 mutants exhibit a surprising cooperative effect leading to a reduction in the free-energy barrier for proton permeation around the NPA region due to altered water configurations in the SF region, with AQP1-R195S having a higher conductance than AQP1-R195V.	Water	167-172	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	211-215
21277313-7	2011	Both AQP1 mutants exhibit a surprising cooperative effect leading to a reduction in the free-energy barrier for proton permeation around the NPA region due to altered water configurations in the SF region, with AQP1-R195S having a higher conductance than AQP1-R195V.	Water	167-172	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	211-215
21477270-2	2011	Artificial expression of water-selective aquaporins or aquaglyceroporins (GLPs), such as mammalian aquaporin-3 (AQP3), enhances cell permeability to water and cryoprotectants, but it is known that AQP3-mediated water and solute permeation is limited and pH dependent.	Water	25-30	aquaporin 3 (Gill blood group)	Homo sapiens	99-110
21477270-2	2011	Artificial expression of water-selective aquaporins or aquaglyceroporins (GLPs), such as mammalian aquaporin-3 (AQP3), enhances cell permeability to water and cryoprotectants, but it is known that AQP3-mediated water and solute permeation is limited and pH dependent.	Water	25-30	aquaporin 3 (Gill blood group)	Homo sapiens	112-116
21477270-2	2011	Artificial expression of water-selective aquaporins or aquaglyceroporins (GLPs), such as mammalian aquaporin-3 (AQP3), enhances cell permeability to water and cryoprotectants, but it is known that AQP3-mediated water and solute permeation is limited and pH dependent.	Water	25-30	aquaporin 3 (Gill blood group)	Homo sapiens	197-201
21477270-2	2011	Artificial expression of water-selective aquaporins or aquaglyceroporins (GLPs), such as mammalian aquaporin-3 (AQP3), enhances cell permeability to water and cryoprotectants, but it is known that AQP3-mediated water and solute permeation is limited and pH dependent.	Water	149-154	aquaporin 3 (Gill blood group)	Homo sapiens	99-110
21477270-2	2011	Artificial expression of water-selective aquaporins or aquaglyceroporins (GLPs), such as mammalian aquaporin-3 (AQP3), enhances cell permeability to water and cryoprotectants, but it is known that AQP3-mediated water and solute permeation is limited and pH dependent.	Water	149-154	aquaporin 3 (Gill blood group)	Homo sapiens	112-116
21477270-2	2011	Artificial expression of water-selective aquaporins or aquaglyceroporins (GLPs), such as mammalian aquaporin-3 (AQP3), enhances cell permeability to water and cryoprotectants, but it is known that AQP3-mediated water and solute permeation is limited and pH dependent.	Water	149-154	aquaporin 3 (Gill blood group)	Homo sapiens	99-110
21477270-2	2011	Artificial expression of water-selective aquaporins or aquaglyceroporins (GLPs), such as mammalian aquaporin-3 (AQP3), enhances cell permeability to water and cryoprotectants, but it is known that AQP3-mediated water and solute permeation is limited and pH dependent.	Water	149-154	aquaporin 3 (Gill blood group)	Homo sapiens	112-116
31188544-11	2020	Mannitol-induced water flux was elevated in claudin-15-expressing cells compared to control cells.	Water	17-22	claudin-15	Canis lupus familiaris	44-54
21427539-1	2011	BACKGROUND: Because the aquaporin (AQP) 5 promoter -1364A/C polymorphism is associated with altered AQP5 expression, this association could have an impact on key mechanisms in sepsis, such as cell migration, activity of the rennin-angiotensin- aldosterone system (RAAS), and water transport across biologic membranes.	Water	275-280	aquaporin 5	Homo sapiens	100-104
22095771-1	2012	The formic acid catalyzed gas-phase reaction between H(2)O and SO(3) and its reverse reaction are respectively investigated by means of quantum chemical calculations at the CCSD(T)//B3LYP/cc-pv(T+d)z and CCSD(T)//MP2/aug-cc-pv(T+d)z levels of theory.	Water	53-58	tryptase pseudogene 1	Homo sapiens	213-216
31188544-12	2020	In contrast to the Na+ -coupled water flux of claudin-2 channels, claudin-15-mediated water flux was inhibited by Na+ flux.	Water	86-91	claudin-15	Canis lupus familiaris	66-76
31188544-14	2020	Likewise, Na+ flux was decreased after induction of water flux through claudin-15.	Water	52-57	claudin-15	Canis lupus familiaris	71-81
22132877-2	2012	The temperature for the decomposition of the precursors and the formation of CIS was lowered significantly to 130  C by using the strongly coordinating solvent pyridine instead of the commonly used water.	Water	198-203	cytokine inducible SH2 containing protein	Homo sapiens	77-80
21320778-3	2011	One possible rationale for these data is that water or product (acetate) transit through the catalytically crucial internal channel of HDAC8 is regulated by a gating interaction between G139 and G303 tethered in position by the conserved R37.	Water	46-51	histone deacetylase 8	Homo sapiens	135-140
31188544-15	2020	CONCLUSION: Claudin-15, similar to claudin-2, forms a paracellular cation and water channel.	Water	78-83	claudin-15	Canis lupus familiaris	12-22
31188544-16	2020	In functional contrast to claudin-2, water and Na+ fluxes through claudin-15 inhibit each other.	Water	37-42	claudin-15	Canis lupus familiaris	66-76
31707352-13	2020	Besides, AQP3 which mediated intracellular signal transmission and transported H2O2 into cells was significantly increased in the presence of Cordyceps extract against UVB irradiation.	Water	79-83	aquaporin 3 (Gill blood group)	Homo sapiens	9-13
21347573-1	2011	Aquaporin-4 (AQP4), a member of the water channel family, has high water permeability and multi-functional potentiality.	Water	36-41	aquaporin 4	Gallus gallus	0-11
21347573-1	2011	Aquaporin-4 (AQP4), a member of the water channel family, has high water permeability and multi-functional potentiality.	Water	36-41	aquaporin 4	Gallus gallus	13-17
21347573-1	2011	Aquaporin-4 (AQP4), a member of the water channel family, has high water permeability and multi-functional potentiality.	Water	67-72	aquaporin 4	Gallus gallus	0-11
21881002-1	2012	Vasopressin (AVP)-stimulated translocation and transcription of aquaporin-2 (AQP2) water channels in renal principal cells is essential for urine concentration.	Water	83-88	aquaporin 2	Mus musculus	64-75
21881002-1	2012	Vasopressin (AVP)-stimulated translocation and transcription of aquaporin-2 (AQP2) water channels in renal principal cells is essential for urine concentration.	Water	83-88	aquaporin 2	Mus musculus	77-81
22687538-1	2012	Aquaporin (AQP) 3, which is predominantly expressed in the colon, is considered to play an important role in regulating the fecal water content in the colon.	Water	130-135	aquaporin 3 (Gill blood group)	Rattus norvegicus	0-17
22687538-8	2012	Therefore, it has been revealed that the fecal water content in the colon is controlled by the transport of water from the luminal side to the vascular side, which is mediated by AQP3.	Water	47-52	aquaporin 3 (Gill blood group)	Rattus norvegicus	179-183
21178974-2	2011	In a mouse cortical collecting duct cell line (mCCD(c11)), physiological concentrations of arginine vasopressin increased both electrogenic, amiloride-sensitive, epithelial sodium channel (ENaC)-mediated sodium transport measured by the short-circuit current (Isc) method and water flow (Jv apical to basal) measured by gravimetry with similar activation coefficient K(1/2) (6 and 12 pM, respectively).	Water	276-281	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	189-193
21178974-7	2011	Around 30% of baseline and 50% of vasopressin-induced water flow is coupled to an amiloride-sensitive, ENaC-mediated, electrogenic sodium transport, whereas the remaining flow is coupled to an amiloride-insensitive, nonelectrogenic sodium transport mediated by an unknown electroneutral transporter.	Water	54-59	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	103-107
33554224-8	2020	An inducible tumor model in which 4NQO was introduced into the drinking water of Trp53 knockout mice was used to model OCSCC-microenvironment interactions.	Water	72-77	transformation related protein 53	Mus musculus	81-86
21266531-6	2011	We show that sodium arsenite induces ABCB6 expression in a dose-dependent manner both in mice fed sodium arsenite in drinking water and in cells exposed to sodium arsenite in vitro.	Water	126-131	ATP-binding cassette, sub-family B (MDR/TAP), member 6	Mus musculus	37-42
22687538-8	2012	Therefore, it has been revealed that the fecal water content in the colon is controlled by the transport of water from the luminal side to the vascular side, which is mediated by AQP3.	Water	108-113	aquaporin 3 (Gill blood group)	Rattus norvegicus	179-183
33958812-11	2020	The MVG provides evidence for the presence of large, persistent standing bodies of water on early Mars as well as a complex association of flanking shoreline, alluvial, and aeolian systems.	Water	83-88	methionyl-tRNA synthetase 1	Homo sapiens	98-102
23171819-1	2012	BACKGROUND: In the renal collecting duct, vasopressin regulates water permeability by a process that involves stimulation of adenylyl cyclase activity, cAMP production and subsequent translocation of water channel aquaporin-2 (AQP2) into the apical plasma membrane.	Water	64-69	aquaporin 2	Rattus norvegicus	227-231
23171819-1	2012	BACKGROUND: In the renal collecting duct, vasopressin regulates water permeability by a process that involves stimulation of adenylyl cyclase activity, cAMP production and subsequent translocation of water channel aquaporin-2 (AQP2) into the apical plasma membrane.	Water	200-205	aquaporin 2	Rattus norvegicus	214-225
23171819-1	2012	BACKGROUND: In the renal collecting duct, vasopressin regulates water permeability by a process that involves stimulation of adenylyl cyclase activity, cAMP production and subsequent translocation of water channel aquaporin-2 (AQP2) into the apical plasma membrane.	Water	200-205	aquaporin 2	Rattus norvegicus	227-231
21566283-7	2011	The water submerged heating group had the lowest P-gp expression and the highest gammaH2AX expression among different heating groups at 42 degree and 45 degree in MCF-7/Adr cells (P&lt;0.05).	Water	4-9	phosphoglycolate phosphatase	Homo sapiens	49-53
32863888-0	2020	Tender coconut water suppresses hepatic inflammation by activating AKT and JNK signaling pathways in an in vitro model of sepsis.	Water	15-20	mitogen-activated protein kinase 8	Rattus norvegicus	75-78
21375261-3	2011	As the tip approaches the solid substrate, interfacial water undergoes conformational and structural changes.	Water	55-60	TOR signaling pathway regulator	Homo sapiens	7-10
22591021-4	2012	The increases in water and sodium absorption via AQP2 and ENaC after furosemide treatment most likely are compensatory phenomena to antagonize water and sodium depletion.	Water	17-22	aquaporin 2	Homo sapiens	49-53
22591021-4	2012	The increases in water and sodium absorption via AQP2 and ENaC after furosemide treatment most likely are compensatory phenomena to antagonize water and sodium depletion.	Water	143-148	aquaporin 2	Homo sapiens	49-53
32758801-1	2020	Diffusion magnetic resonance imaging (dMRI) is an imaging technique which probes the random motion of water molecules in tissues and has been widely applied to investigate changes in white matter microstructure in Alzheimer"s Disease.	Water	102-107	mrityu	Drosophila melanogaster	38-42
21178146-2	2011	METHODS: EAU was induced by S-antigen peptide in Lewis rats.	Water	9-12	S-antigen visual arrestin	Rattus norvegicus	28-37
23113172-9	2012	RESULTS: 25.9% of the water samples contained different species of NTM.	Water	22-27	neurotrimin	Homo sapiens	67-70
33274889-6	2020	The meat treated by 10% of bacteriocin gave the lower total microbial (3rd and 5th day) and total E. coli (5th day) at 7 and 26 C. The pH and water activity (aw) values of chicken meat with 10% of bacteriocin showed lower values at 7 and 26 C. The application of bacteriocin to chicken meat was able to inhibit the microbial growth that was still below standard for 3 days at 7 C and 6 hrs at 26 C. CONCLUSION: Based on research, lactic acid bacteria isolated from buffalo milk curd produced bacteriocin compound which has antimicrobial properties.	Water	142-147	colicin E1 protein	Escherichia coli	27-38
21408176-1	2011	BACKGROUND: Aquaporin-4 (AQP4) constitutes the principal water channel in the brain and is clustered at the perivascular astrocyte endfeet.	Water	57-62	aquaporin 4	Rattus norvegicus	12-23
21408176-1	2011	BACKGROUND: Aquaporin-4 (AQP4) constitutes the principal water channel in the brain and is clustered at the perivascular astrocyte endfeet.	Water	57-62	aquaporin 4	Rattus norvegicus	25-29
21940718-7	2012	The results suggest a hypothetical model whereby Ca(2+)(o) induces H(2)O(2) and NO accumulation in guard cells through the CAS signalling pathway, which further triggers Ca(2+)(i) transients and finally stomatal closure.	Water	67-72	BCAR1 scaffold protein, Cas family member	Homo sapiens	123-126
31901837-10	2020	The measurement of absorbed dose to water from 90YCl3 radionuclide solution using LiF:Mg,Cu,P TLDs turned out to be a viable technique, provided that all necessary correction factors are applied.	Water	36-41	LIF interleukin 6 family cytokine	Homo sapiens	82-85
23284726-5	2012	Microarray techniques were used to compare the responses to GLA in an aqueous formulation or in an oil-in-water Stable Emulsion formulation (GLA-SE) versus either SE alone or the mineral salt aluminum hydroxide (alum) at the muscle injection site over multiple timepoints.	Water	106-111	galactosidase, alpha	Mus musculus	60-63
21168316-0	2011	Aquaporin 1 water channel is expressed on submucosal but not myenteric neurons from the ovine duodenum.	Water	12-17	aquaporin-1	Ovis aries	0-11
21168316-2	2011	Increasing evidence indicates that an aquaporin 1 (AQP1) water channel is present on the surface of discrete neuronal classes of the central as well peripheral nervous systems.	Water	57-62	aquaporin-1	Ovis aries	38-49
21168316-2	2011	Increasing evidence indicates that an aquaporin 1 (AQP1) water channel is present on the surface of discrete neuronal classes of the central as well peripheral nervous systems.	Water	57-62	aquaporin-1	Ovis aries	51-55
21168316-6	2011	Under normal conditions, approximately 30% of submucosal neurons exhibit the presence of AQP1 water channels.	Water	94-99	aquaporin-1	Ovis aries	89-93
21278343-7	2011	Knockdown of p120 also increased the expression of ICAM-1, neutrophil recruitment, production of cytokines TNF-alpha and IL-6, pulmonary transvascular protein permeability, and lung water content in response to LPS.	Water	182-187	catenin (cadherin associated protein), delta 1	Mus musculus	13-17
31810001-7	2020	HO-1 attenuated reactive oxygen species induced by H2O2 or pyocyanin treatment in PC-3 and DU145 cells.	Water	51-55	heme oxygenase 1	Homo sapiens	0-4
21042825-8	2011	Incisions performed using the 100/0% air/water spray regulation had the worst results, expressing a greater amount of fibronectin and type III collagen.	Water	41-46	fibronectin 1	Rattus norvegicus	118-129
23152789-10	2012	Tightly bound water molecules were predicted to be localized in the pentasaccharide binding pocket of antithrombin, but absent in thrombin.	Water	14-19	serpin family C member 1	Homo sapiens	102-114
31810001-8	2020	HO-1 further reduced PC-3 and DU145 cell apoptosis induced by H2O2 or serum starvation.	Water	62-66	heme oxygenase 1	Homo sapiens	0-4
31934268-12	2019	Additionally, Ubisol-Q10 supplementation in the drinking water of double transgenic AD mice leads to increased expression of beclin-1 and JNK1 in the cortical region.	Water	57-62	beclin 1, autophagy related	Mus musculus	125-133
23133642-1	2012	BACKGROUND: KCNQ1 (potassium voltage-gated channel KQT-like sub-family, member 1) encodes a pore-forming subunit of a voltage-gated K(+) channel (KvLQT1) that plays a key role for the repolarization of the cardiac action potential as well as water and salt transport in epithelial tissues.	Water	242-247	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	12-17
23133642-1	2012	BACKGROUND: KCNQ1 (potassium voltage-gated channel KQT-like sub-family, member 1) encodes a pore-forming subunit of a voltage-gated K(+) channel (KvLQT1) that plays a key role for the repolarization of the cardiac action potential as well as water and salt transport in epithelial tissues.	Water	242-247	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	19-80
23133642-1	2012	BACKGROUND: KCNQ1 (potassium voltage-gated channel KQT-like sub-family, member 1) encodes a pore-forming subunit of a voltage-gated K(+) channel (KvLQT1) that plays a key role for the repolarization of the cardiac action potential as well as water and salt transport in epithelial tissues.	Water	242-247	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	146-152
21145339-4	2011	The sea-water temperature does not seem to be a primary driver, and the maximal abundance periods were site and year specific.	Water	8-13	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	4-7
21280613-3	2011	This Pdot was comparable in size to a water-soluble NIR quantum dot that emits at 800 nm (ITK Qdot800) but was about four times brighter and with a narrower emission peak.	Water	38-43	IL2 inducible T cell kinase	Homo sapiens	90-93
31861354-0	2019	Fast Degradation of Bisphenol A in Water by Nanostructured CuNPs@CALB Biohybrid Catalysts.	Water	35-40	calbindin 1	Homo sapiens	65-69
21247114-0	2011	Synthesis and physicochemical characterization of carbon backbone modified [Gd(TTDA)(H2O)]2- derivatives.	Water	85-88	general transcription factor IIH subunit 5	Homo sapiens	79-83
23029160-2	2012	Low-Ca(2+) fresh water stimulated Ca(2+) influx and expressions of epithelial calcium channel (ecac), vitamin D-25-hydroxylase (cyp2r1), vitamin D receptor a (vdra), and vdrb in zebrafish.	Water	17-22	vitamin D receptor b	Danio rerio	170-174
31736309-5	2019	The concentration of PSA can be measured through both the increase of differential pulse voltammetry (DPV) signal change of Thi and the decrease of chronoamperometry (CA) signal of the reduction of H2O2 electrocatalyzed by GO-Fe3O4.	Water	198-202	kallikrein related peptidase 3	Homo sapiens	21-24
22808259-1	2012	BACKGROUND: Aquaporin3 (AQP3) and Aquaporin4 (AQP4) play a major role in transcellular and transepithelial water movement as water channel membrane proteins.	Water	107-112	aquaporin 3 (Gill blood group)	Homo sapiens	12-22
22808259-1	2012	BACKGROUND: Aquaporin3 (AQP3) and Aquaporin4 (AQP4) play a major role in transcellular and transepithelial water movement as water channel membrane proteins.	Water	107-112	aquaporin 3 (Gill blood group)	Homo sapiens	24-28
21112139-1	2011	Alizarin Red S (ARS), is a water-soluble, widely used anthraquinone dye synthesized by sulfonation of alizarin.	Water	27-32	secreted LY6/PLAUR domain containing 1	Homo sapiens	16-19
31920551-10	2019	DRP-1 overexpression in HEI-OC1 cells initiated mitophagy and preserved mitochondrial function when exposed to H2O2, while cells with DRP-1 silencing displayed otherwise.	Water	111-115	dynamin 1 like	Homo sapiens	0-5
20205509-5	2011	METHODS: Cytotoxic brain edema was induced in adult CD1 mice via water intoxication by intraperitoneal water administration (30% body weight intraperitoneally).	Water	65-70	CD1 antigen complex	Mus musculus	52-55
22403735-3	2012	This would reduce the abundance of aquaporin-2 (AQP2) and in turn the rate of water reabsorption.	Water	78-83	aquaporin 2	Homo sapiens	35-46
22403735-3	2012	This would reduce the abundance of aquaporin-2 (AQP2) and in turn the rate of water reabsorption.	Water	78-83	aquaporin 2	Homo sapiens	48-52
21083433-4	2011	The aquaporin-4 (AQP4) water channel is predominantly expressed in astrocytes, and it plays an important role in the regulation of brain water homeostasis.	Water	23-28	aquaporin 4	Rattus norvegicus	4-15
22359587-7	2012	alpha7 nAChR agonists (1 microM acetylcholine, 10 microM choline or 30 nM PNU-282987) impaired intramitochondrial Ca(2+) accumulation and significantly decreased cytochrome c release stimulated with either 90 microM CaCl(2) or 0.5 mM H(2)O(2).	Water	234-239	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	0-6
31670325-3	2019	Among these probes, NEiPN showed good water solubility, highly isoform selectivity and great sensitivity (LOD = 0.04874 nM) for CYP1A1 under simulated physiological conditions, which makes it favorable for monitoring CYP1A1 in vivo.	Water	38-43	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	128-134
22359587-7	2012	alpha7 nAChR agonists (1 microM acetylcholine, 10 microM choline or 30 nM PNU-282987) impaired intramitochondrial Ca(2+) accumulation and significantly decreased cytochrome c release stimulated with either 90 microM CaCl(2) or 0.5 mM H(2)O(2).	Water	234-239	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	7-12
21083433-4	2011	The aquaporin-4 (AQP4) water channel is predominantly expressed in astrocytes, and it plays an important role in the regulation of brain water homeostasis.	Water	23-28	aquaporin 4	Rattus norvegicus	17-21
21083433-4	2011	The aquaporin-4 (AQP4) water channel is predominantly expressed in astrocytes, and it plays an important role in the regulation of brain water homeostasis.	Water	137-142	aquaporin 4	Rattus norvegicus	4-15
21083433-4	2011	The aquaporin-4 (AQP4) water channel is predominantly expressed in astrocytes, and it plays an important role in the regulation of brain water homeostasis.	Water	137-142	aquaporin 4	Rattus norvegicus	17-21
22348872-3	2012	In the visual water task, a cortex-dependent task based on visual discrimination learning, visual acuity remained stable at 0.58 cyc/deg up to 21 months and then declined to 0.48 cyc/deg (by 19%) at 27 months.	Water	14-19	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	129-132
31885814-8	2019	Consistent with Nrf2 knockdown, the PI3K/Akt inhibitor LY294002 significantly suppressed RSV-induced Nrf2 phosphorylation and RSV-induced increase of TJ protein levels and antioxidant gene expression under H2O2 treatment (P &lt; 0.05).	Water	206-210	AKT serine/threonine kinase 1	Sus scrofa	41-44
23109565-5	2012	From entry point (raw sewage) to effluent level (tertiary treatment effluent water), the experimental results showed that the reduction ratios of human adenoviruses were 1.2 log10 in STP1 and 1.9 log10 in STP2.	Water	77-82	transition protein 1	Homo sapiens	183-195
22860163-1	2011	The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-beta and tau peptide aggregation is presented.	Water	19-24	microtubule associated protein tau	Homo sapiens	152-155
21142131-1	2011	The neutral molecule temperature dependence of the rate coefficient for the electron transfer reaction from H(2)O to N(2)(+) is determined using a coaxial molecular beam radio frequency ring electrode ion trap (CoMB-RET) method.	Water	108-113	ret proto-oncogene	Homo sapiens	216-219
21058017-5	2011	The capacity of the MISs was measured by the extraction of increasing amounts of 2,4-DNT in pure water and is higher than 3.2 mg/g of sorbent for each MIS.	Water	97-102	5', 3'-nucleotidase, cytosolic	Homo sapiens	85-88
22116364-7	2011	Interestingly, the water channel AQP5 was recently found to be expressed at the apical side of B-ICs, in the absence of a basolateral water channel, and pendrin and AQP5 membrane expressions are both inhibited by K(+) depletion, suggesting that pendrin and AQP5 could cooperate to regulate cell volume, a potent stimulus of ATP release.	Water	19-24	solute carrier family 26, member 4	Mus musculus	245-252
22116370-7	2011	The present study thus examined the expression of Slc26a4 in liver and kidney of mice drinking tap water without or with NaHCO(3) (150 mM), NH(4)Cl (280 mM) or acetazolamide (3.6 mM) for seven days.	Water	99-104	solute carrier family 26, member 4	Mus musculus	50-57
30451023-7	2019	Aquaporin 5 modulates water influx through ion transporters to prevent osmotic imbalance.	Water	22-27	aquaporin 5	Homo sapiens	0-11
22178941-7	2011	Sulphurous mineral water and NaHS treatment may have improved the level of testicular GSH by blocking the overexpression of some apoptosis-related regulatory proteins such as Bax/Bcl-2, cytochrome c, caspase-9 and -3, and p53.	Water	19-24	BCL2 associated X, apoptosis regulator	Rattus norvegicus	175-178
22178941-7	2011	Sulphurous mineral water and NaHS treatment may have improved the level of testicular GSH by blocking the overexpression of some apoptosis-related regulatory proteins such as Bax/Bcl-2, cytochrome c, caspase-9 and -3, and p53.	Water	19-24	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	222-225
22115779-1	2011	800 MHz NMR structure of the 28-residue peptide thymosin alpha-1 in 40% TFE/60% water (v/v) has been determined.	Water	80-85	adrenoceptor alpha 1D	Homo sapiens	57-64
31638263-11	2019	Silencing of FABP4 also generated cytoprotective effects against H2O2 in human endometrial stromal cells.	Water	65-69	fatty acid binding protein 4	Homo sapiens	13-18
22202470-3	2011	Because some PAHs such as Benzo[a]pyrene (BaP) are proven carcinogens and mutagens, it is necessary to continuously monitor their concentrations in the air, water, and soil.	Water	157-162	prohibitin 2	Homo sapiens	42-45
20965250-9	2011	In addition, MTII loaded THCPSi changed the water consumption after 150 min, when the immediate effect of MTII solution was already diminished.	Water	44-49	metallothionein 2A	Homo sapiens	13-17
31698021-8	2019	Further experiments showed that exposure of SK-N-BE(2)-M17 cells to H2O2 caused an increased level of noradrenergic transporter, reduced protein levels of copper transporter (Ctr1) and 8-oxoGua DNA glycosylase, as well as amplified levels of Cav1.2 and Cav1.3 expression.	Water	68-72	solute carrier family 31 member 1	Rattus norvegicus	175-179
20849844-0	2011	Aquaporin-4 water channel oligomers are associated with the transverse tubules of skeletal myofibers.	Water	12-17	aquaporin 4	Rattus norvegicus	0-11
20849844-2	2011	Here we have examined whether the T tubules contain aquaporin type 4 (AQP4) water channels to mediate rapid transmembrane water flow.	Water	76-81	aquaporin 4	Rattus norvegicus	70-74
20849844-2	2011	Here we have examined whether the T tubules contain aquaporin type 4 (AQP4) water channels to mediate rapid transmembrane water flow.	Water	122-127	aquaporin 4	Rattus norvegicus	52-68
20849844-2	2011	Here we have examined whether the T tubules contain aquaporin type 4 (AQP4) water channels to mediate rapid transmembrane water flow.	Water	122-127	aquaporin 4	Rattus norvegicus	70-74
22295784-1	2011	The photoluminescence property of CdS/PAMAM nanocomposites in water at different ratio of Cd2+ to PAMAM(r) was studied by fluorescence emission spectrum, and the according mechanism was explored.	Water	62-67	CD2 molecule	Homo sapiens	90-93
31795228-9	2019	Our study also showed significant neuroprotection by oxidized Ole and oxidized Mix against H2O2 toxicity on SK-N-SH cells, after 24 h of treatment with very low concentrations (1 and 5 nM).	Water	91-95	Mix paired-like homeobox	Homo sapiens	79-82
22052052-6	2011	Similarly, levels of aquaporin-2 protein in inner and outer medulla after water deprivation were significantly lower in CD-KO mice compared with controls, despite its normal localization to the apical membrane.	Water	74-79	aquaporin 2	Mus musculus	21-32
21792355-7	2011	Both ricin and SEB were detected by HHAs in formulated tap water at or below the suggested health effect levels of 455 ng/mL and 4.55 ng/mL, respectively.	Water	59-64	filamin B	Homo sapiens	55-58
31776360-4	2019	The mechanism involves signaling by mitochondria-generated H2O2 (mH2O2) acting via the redox sensor, peroxiredoxin-1, a thiol peroxidase with high reactivity towards H2O2 that activates c-Jun N-terminal kinase-2alpha2 (JNK2alpha2).	Water	59-63	peroxiredoxin 1	Mus musculus	101-116
21082368-6	2011	Extensive infoldings of the plasma-facing basal labyrinth together with lush microvilli at the CSF-facing membrane afford surface area, as great as that at BBB, for epithelial solute and water exchange.	Water	187-192	colony stimulating factor 2	Homo sapiens	95-98
21082368-7	2011	CSF formation occurs by basolateral carrier-mediated uptake of Na+, Cl-, and HCO3-, followed by apical release via ion channel conductance and osmotic flow of water through AQP1 channels.	Water	159-164	colony stimulating factor 2	Homo sapiens	0-3
22112087-8	2011	MP2 results suggest the possibility of finding traces of C7eq conformer in water solution, in agreement with recent experiments.	Water	75-80	tryptase pseudogene 1	Homo sapiens	0-3
21989727-7	2011	RESULTS: IRBPp-specific CD25+CD4+ T cells from spleens of EAU-recovered wild-type mice express a Treg cell phenotype of FoxP3 and TGF-beta compared with the effector T-cell phenotype of IFN-gamma and IL-17 production in EAU-recovered MC5r-/- mice.	Water	58-61	forkhead box P3	Mus musculus	120-125
31776360-4	2019	The mechanism involves signaling by mitochondria-generated H2O2 (mH2O2) acting via the redox sensor, peroxiredoxin-1, a thiol peroxidase with high reactivity towards H2O2 that activates c-Jun N-terminal kinase-2alpha2 (JNK2alpha2).	Water	66-70	peroxiredoxin 1	Mus musculus	101-116
31776360-4	2019	The mechanism involves signaling by mitochondria-generated H2O2 (mH2O2) acting via the redox sensor, peroxiredoxin-1, a thiol peroxidase with high reactivity towards H2O2 that activates c-Jun N-terminal kinase-2alpha2 (JNK2alpha2).	Water	66-70	peroxiredoxin 1	Mus musculus	101-116
21788318-0	2011	The effect of a new water-soluble sedative-hypnotic drug, JM-1232(-), on long-term potentiation in the CA1 region of the mouse hippocampus.	Water	20-25	carbonic anhydrase 1	Mus musculus	103-106
20941531-5	2011	H(2)O(2) significantly increased intracellular ROS generation and apoptotic cells as expected, and all these cellular events were greatly inhibited by overexpression of HSF1.	Water	0-5	heat shock transcription factor 1	Rattus norvegicus	169-173
31398432-10	2019	The water ADC was measured to be 1.3 times larger at short than at long diffusion time.	Water	4-9	antizyme inhibitor 2	Homo sapiens	10-13
31253288-3	2019	Under optimal conditions, the detection limits of the method measured at the signal to noise ratio of 3 (S/N = 3) were 0.04-0.06 ng mL-1 for tap water and 0.10-0.20 ng mL-1 for black tea drinks and peach juice samples.	Water	145-150	L1 cell adhesion molecule	Mus musculus	132-144
22092816-5	2011	alpha-Toxin is a 33.2-kDa, water-soluble, pore-forming toxin that is secreted by most S. aureus strains.	Water	27-32	AT695_RS01930	Staphylococcus aureus	6-11
22092816-5	2011	alpha-Toxin is a 33.2-kDa, water-soluble, pore-forming toxin that is secreted by most S. aureus strains.	Water	27-32	AT695_RS01930	Staphylococcus aureus	55-60
31545472-10	2019	It was found that CdM downregulated H2O2-stimulated 8-hydroxydeoxyguanosine and gamma-H2AX levels and decreased the expression of the senescence-associated proteins p21 and p16.	Water	36-40	H3 histone pseudogene 16	Homo sapiens	165-168
20848600-4	2011	We show that water maze spatial training evoked a biphasic response of pCREB in the CA1, with two different peaks occurring 15 min and 8 h postacquisition.	Water	13-18	carbonic anhydrase 1	Mus musculus	84-87
31618043-0	2019	Toward a Greener Barluenga-Valdes Cross-Coupling: Microwave-Promoted C-C Bond Formation with a Pd/PEG/H2O Recyclable Catalytic System.	Water	102-116	progestagen associated endometrial protein	Homo sapiens	98-101
21357632-8	2011	Meanwhile, at the same exposure dose, water-soluble fraction caused more significant increase of MDA, IL-6, TNF-alpha and P-selectin and decrease of cell viability and NO when compared to organic extracts.	Water	38-43	selectin P	Homo sapiens	122-132
31618043-2	2019	The new catalytic system based on Pd/Xphos-SO3Na or Pd/MeDavephos-CF3SO3 in PEG/H2O under microwave irradiation was found to be the best conditions for this transformation.	Water	80-83	progestagen associated endometrial protein	Homo sapiens	76-79
22037469-3	2011	Here we show that the GMPR reaction uses the same intermediate E-XMP* as IMPDH, but in this reaction the intermediate reacts with ammonia instead of water.	Water	149-154	guanosine monophosphate reductase	Homo sapiens	22-26
31580067-3	2019	To address the issue, water-dispersible nanocomposites (COF@IR783) produced through the assembly of cyanines and COFs are proposed and prepared.	Water	22-27	cofilin 1, non-muscle	Mus musculus	56-65
22013889-7	2011	Enzyme cavities, identified using CASTp at various probe sizes, indicate that psychrophilic enzymes have larger average cavity sizes at probe radii of 1.4-1.5 A, sufficient for water molecules.	Water	177-182	calpastatin	Homo sapiens	34-39
31560533-7	2019	From 1 as a starting material, its reaction with lanthanide ions results in the bimetallic Dy(H2O)3[Ru2(Hamdp)2][Ru2(Hamdp)2(H2O)2][Ru2(Hamdp)(amdp)]0.5 12H2O (2), which has a pillared-bilayer structure and Yb[Ru2(Hamdp)2]2[Ru2(Hamdp)2(H2O)2] 15H2O (3), which is a three-dimensional open framework, both contain mixed-valent RuII/III2 units and show new connection topologies of the Ru2 dimers.	Water	153-158	doublecortin domain containing 2	Homo sapiens	100-103
21992330-7	2011	Analysis of the ORR free energy diagrams, built for the Pd and Pd/Pd(0.75)Co(0.25), shows that the co-adsorption of the ORR intermediates and water changes the ORR energetics significantly and makes ORR more favorable.	Water	142-147	discs overgrown	Drosophila melanogaster	99-101
31560533-7	2019	From 1 as a starting material, its reaction with lanthanide ions results in the bimetallic Dy(H2O)3[Ru2(Hamdp)2][Ru2(Hamdp)2(H2O)2][Ru2(Hamdp)(amdp)]0.5 12H2O (2), which has a pillared-bilayer structure and Yb[Ru2(Hamdp)2]2[Ru2(Hamdp)2(H2O)2] 15H2O (3), which is a three-dimensional open framework, both contain mixed-valent RuII/III2 units and show new connection topologies of the Ru2 dimers.	Water	153-158	doublecortin domain containing 2	Homo sapiens	113-116
31560533-7	2019	From 1 as a starting material, its reaction with lanthanide ions results in the bimetallic Dy(H2O)3[Ru2(Hamdp)2][Ru2(Hamdp)2(H2O)2][Ru2(Hamdp)(amdp)]0.5 12H2O (2), which has a pillared-bilayer structure and Yb[Ru2(Hamdp)2]2[Ru2(Hamdp)2(H2O)2] 15H2O (3), which is a three-dimensional open framework, both contain mixed-valent RuII/III2 units and show new connection topologies of the Ru2 dimers.	Water	153-158	doublecortin domain containing 2	Homo sapiens	113-116
21826354-0	2011	Gold(I) complexes of water-soluble diphos-type ligands: synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition.	Water	21-26	peroxiredoxin 5	Homo sapiens	102-123
31560533-7	2019	From 1 as a starting material, its reaction with lanthanide ions results in the bimetallic Dy(H2O)3[Ru2(Hamdp)2][Ru2(Hamdp)2(H2O)2][Ru2(Hamdp)(amdp)]0.5 12H2O (2), which has a pillared-bilayer structure and Yb[Ru2(Hamdp)2]2[Ru2(Hamdp)2(H2O)2] 15H2O (3), which is a three-dimensional open framework, both contain mixed-valent RuII/III2 units and show new connection topologies of the Ru2 dimers.	Water	153-158	doublecortin domain containing 2	Homo sapiens	113-116
31560533-7	2019	From 1 as a starting material, its reaction with lanthanide ions results in the bimetallic Dy(H2O)3[Ru2(Hamdp)2][Ru2(Hamdp)2(H2O)2][Ru2(Hamdp)(amdp)]0.5 12H2O (2), which has a pillared-bilayer structure and Yb[Ru2(Hamdp)2]2[Ru2(Hamdp)2(H2O)2] 15H2O (3), which is a three-dimensional open framework, both contain mixed-valent RuII/III2 units and show new connection topologies of the Ru2 dimers.	Water	153-158	doublecortin domain containing 2	Homo sapiens	113-116
31560533-7	2019	From 1 as a starting material, its reaction with lanthanide ions results in the bimetallic Dy(H2O)3[Ru2(Hamdp)2][Ru2(Hamdp)2(H2O)2][Ru2(Hamdp)(amdp)]0.5 12H2O (2), which has a pillared-bilayer structure and Yb[Ru2(Hamdp)2]2[Ru2(Hamdp)2(H2O)2] 15H2O (3), which is a three-dimensional open framework, both contain mixed-valent RuII/III2 units and show new connection topologies of the Ru2 dimers.	Water	153-158	doublecortin domain containing 2	Homo sapiens	113-116
21787751-0	2011	The Seryl-tRNA synthetase/tRNASer acceptor stem interface is mediated via a specific network of water molecules.	Water	96-101	seryl-tRNA synthetase 1	Homo sapiens	4-25
31437586-4	2019	Analysis of probe data revealed that aged animals treated with gp120 demonstrated profound decrements in water maze performance compared to gp120 treated young animals and saline treated aged or young animals.	Water	105-110	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	63-68
21755996-8	2011	3.0 to 6.2 for 2- to 6-ring parent PAHs, and correlated well with SPARC octanol/water coefficients (K(OW)) (correlation coefficient of r(2) = 0.986).	Water	80-85	secreted protein acidic and cysteine rich	Homo sapiens	66-71
31279271-0	2019	Two dimensional metal-organic frameworks-derived leaf-like Co4S3/CdS composite for enhancing photocatalytic water evolution.	Water	108-113	CDP-diacylglycerol synthase 1	Homo sapiens	65-68
31612959-6	2019	Poor sanitation, younger age and living in a household that purchased water from a vendor were associated with TF in children aged 1-9 y.	Water	70-75	coagulation factor III, tissue factor	Homo sapiens	111-113
21486309-2	2011	Plants using the C(4) pathway of carbon metabolism are marked by greater photosynthetic water and nitrogen-use efficiencies (PWUE and PNUE, respectively) than C(3) species, but it is unclear to what extent this is the case in C(3) -C(4) intermediate species.	Water	88-93	complement C4A (Rodgers blood group)	Homo sapiens	17-21
21575091-0	2011	Arabidopsis mutants of AtABCG22, an ABC transporter gene, increase water transpiration and drought susceptibility.	Water	67-72	ABC-2 type transporter family protein	Arabidopsis thaliana	23-31
21575091-6	2011	The atabcg22 mutant plants had lower leaf temperatures and increased water loss, implying elevated transpiration through an influence on stomatal regulation.	Water	69-74	ABC-2 type transporter family protein	Arabidopsis thaliana	4-12
21575091-10	2011	The atabcg22 mutation further increased the water loss of srk2e/ost1 mutants, which were defective in ABA signalling in guard cells.	Water	44-49	ABC-2 type transporter family protein	Arabidopsis thaliana	4-12
31755338-7	2019	As a result, treatment of mice with 10% high glucose enriched water increased secretion of insulin/IGF1 and reduced A20 protein level, the effects were blunted in Akt2-/- mice.	Water	62-67	thymoma viral proto-oncogene 2	Mus musculus	163-167
31262500-0	2019	Vulnerability to bioinvasions: Current status, risk assessment and management of ballast water through a regional approach - the Adriatic Sea.	Water	89-94	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	138-141
21715674-6	2011	This could be explained by C(4) plants having higher COS concentrations at the CA site (maintaining high A(s) with reduced CA) and a high phosphoenolpyruvate carboxylase/CA activity ratio (reducing (18)O exchange efficiency between CO(2) and water, but not A(s)).	Water	242-247	complement C4A (Rodgers blood group)	Homo sapiens	27-31
21640636-1	2011	Single crystals of cadmium manganese thiocyanate, CdMn(SCN)4 (CMTC) have been successfully synthesized and grown by slow evaporation solution growth technique using water as solvent at room temperature.	Water	165-170	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	50-60
31579421-11	2019	In addition, the downregulation of XBP1 significantly enhanced the sensitivity of SOC cells to H2O2 by increasing the intracellular ROS levels.	Water	95-99	X-box binding protein 1	Homo sapiens	35-39
21621589-2	2011	Unlike other AQPs, multiple isoforms of AQP4 have been reported in diverse tissues, three of which, M1, M23, and Mz, function as water channels.	Water	129-134	aquaporin 4	Rattus norvegicus	40-44
31576091-12	2019	After treatment with Sirt1-siRNA or Sirt1 inhibitor (EX527), the hyperacetylated HMGB1 in hepatocytes increased, and Sirt1 activity inhibited by H2O2 could be reversed by Parp1 inhibitor (DIQ).	Water	145-149	sirtuin 1	Mus musculus	21-26
31576091-12	2019	After treatment with Sirt1-siRNA or Sirt1 inhibitor (EX527), the hyperacetylated HMGB1 in hepatocytes increased, and Sirt1 activity inhibited by H2O2 could be reversed by Parp1 inhibitor (DIQ).	Water	145-149	sirtuin 1	Mus musculus	36-41
21546030-5	2011	With a hydrophilic tip, the concentric rings were formed due to stick-slip motion of the solvent contact line resulting from competition between pinning and capillary forces while the capillary effect was not effective until the surface of the tip was changed by adherent NPs making the tip surface available for water adherence with a hydrophobic tip, which results in the pulling of droplet towards the tip.	Water	313-318	TOR signaling pathway regulator	Homo sapiens	19-22
31576091-12	2019	After treatment with Sirt1-siRNA or Sirt1 inhibitor (EX527), the hyperacetylated HMGB1 in hepatocytes increased, and Sirt1 activity inhibited by H2O2 could be reversed by Parp1 inhibitor (DIQ).	Water	145-149	sirtuin 1	Mus musculus	36-41
31557892-9	2019	Further analysis showed that the rising water elevation in the Bohai Sea is mostly attributed to the influence of onshore winds, and the negative storm surge in the South Yellow Sea is mainly caused by offshore winds.	Water	40-45	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	69-72
21441404-0	2011	Aquaporin-facilitated water uptake in barley (Hordeum vulgare L.) roots.	Water	22-27	HvPIP2;3	Hordeum vulgare	0-9
21441404-1	2011	It is not known to what degree aquaporin-facilitated water uptake differs between root developmental regions and types of root.	Water	53-58	HvPIP2;3	Hordeum vulgare	31-40
31146864-5	2019	The TTF-COOH could effectively repair electron conductivity of RGO nanosheets, decrease interface resistance, and also enhance the dispersity of TTF-COOH/RGO nanosheets in water.	Water	172-177	ras homolog family member H	Homo sapiens	4-7
21441404-2	2011	The aim of this study was to measure aquaporin-dependent water flow in the main types of root and root developmental regions of 14- to 17-d-old barley plants and to identify candidate aquaporins which mediate this flow.	Water	57-62	HvPIP2;3	Hordeum vulgare	37-46
21524933-1	2011	In the present work, we have studied the electronic structure, molecular electrostatic potential (MEP) and hydrogen bonding in DMSO-ethanol, DMSO-methanol and DMSO-water complexes by employing the MP2 method.	Water	164-169	tryptase pseudogene 1	Homo sapiens	197-200
31146864-5	2019	The TTF-COOH could effectively repair electron conductivity of RGO nanosheets, decrease interface resistance, and also enhance the dispersity of TTF-COOH/RGO nanosheets in water.	Water	172-177	ras homolog family member H	Homo sapiens	145-148
31451815-4	2019	Chloride abstraction of 3 by TlPF6 followed by reaction with [PPh4]2[MnV(N)(CN)4] afforded a diamagnetic red solid that is tentatively formulated as a heterometallic Ce(iv)/Mn(v) complex, [Ce(LOEt)2(H2O){Mn(N)(CN)4}] (5).	Water	199-202	potassium two pore domain channel subfamily K member 3	Homo sapiens	62-66
21972598-0	2011	[Acaricidal activities of the water extract of Xiushan Sea mud against human demodex mites].	Water	30-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	55-58
21972598-1	2011	OBJECTIVE: To observe the acaricidal effect of the water extract of Xiushan sea mud on Demodex brevis and D. folliculorum.	Water	51-56	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
21972598-7	2011	RESULTS: 1.0-2.5 kg/L of the water extract of Xiushan sea mud increased the activities of both kinds of Demodex.	Water	29-34	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	54-57
21972598-18	2011	CONCLUSION: The water extract of Xiushan sea mud shows acaricidal effect to human Demodex.	Water	16-21	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	41-44
22073242-1	2011	BACKGROUND: The novel water soluble compound STA-1474 is metabolized to ganetespib (formerly STA-9090), a potent HSP90 inhibitor previously shown to kill canine tumor cell lines in vitro and inhibit tumor growth in the setting of murine xenografts.	Water	22-27	GCY	Homo sapiens	45-48
22073242-1	2011	BACKGROUND: The novel water soluble compound STA-1474 is metabolized to ganetespib (formerly STA-9090), a potent HSP90 inhibitor previously shown to kill canine tumor cell lines in vitro and inhibit tumor growth in the setting of murine xenografts.	Water	22-27	GCY	Homo sapiens	93-96
22073242-1	2011	BACKGROUND: The novel water soluble compound STA-1474 is metabolized to ganetespib (formerly STA-9090), a potent HSP90 inhibitor previously shown to kill canine tumor cell lines in vitro and inhibit tumor growth in the setting of murine xenografts.	Water	22-27	heat shock protein 90 alpha family class A member 1	Homo sapiens	113-118
31475270-0	2019	Synthesis of Ag2O decorated hierarchical TiO2 templated by double comb copolymers for efficient solar water splitting.	Water	102-107	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	13-16
21603625-7	2011	Whereas 100% of the mice that fed with water only developed prostate tumors at the end of experiment, no tumors could be found in any of the mice fed with PSP, suggesting that PSP treatment can completely inhibit prostate tumor formation.	Water	39-44	persephin	Mus musculus	176-179
21645723-10	2011	This method was also applied to determine BaP in model water sample prepared by adding its different concentrations into tap water.	Water	55-60	prohibitin 2	Homo sapiens	42-45
21645723-10	2011	This method was also applied to determine BaP in model water sample prepared by adding its different concentrations into tap water.	Water	125-130	prohibitin 2	Homo sapiens	42-45
21625555-0	2011	Modeling a new water channel that allows SET9 to dimethylate p53.	Water	15-20	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	41-45
21625555-5	2011	The results show that water leaves the active site of SET9 through a new channel, which is made of G292, A295, Y305 and Y335.	Water	22-27	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	54-58
21625555-6	2011	In addition, the results of molecular docking and MD simulations indicate that the new water channel continues to remain open when S-adenosyl-L-methionine (AdoMet) or S-adenosyl-L-homocysteine (AdoHcy) is bound to SET9.	Water	87-92	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	214-218
31662774-5	2019	Furthermore, MSAE suppressed expression levels of H2O2-induced apoptotic genes such as cleaved caspase-3, caspase-9, and cleaved poly (ADP-ribose) polymerase (PARP).	Water	50-54	caspase 9	Homo sapiens	106-115
21574403-5	2011	By this method, the tracer gases in the sediment pore water of gas hydrate area in South China Sea had been detected.	Water	54-59	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	95-98
21497904-6	2011	Genotoxic potency of the water sample with the highest sulfate concentration was further evaluated using the alkaline, neutral and hOGG1-modified Comet assay on human peripheral blood leukocytes exposed ex vivo for 30 min.	Water	25-30	8-oxoguanine DNA glycosylase	Homo sapiens	131-136
31506661-0	2019	C-CoP hollow microporous nanocages based on phosphating regulation: a high-performance bifunctional electrocatalyst for overall water splitting.	Water	128-133	caspase recruitment domain family member 16	Homo sapiens	2-5
21491501-1	2011	Water channel aquaporin-4 (AQP4) is expressed in astrocytes throughout brain and spinal cord.	Water	0-5	aquaporin 4	Rattus norvegicus	14-25
21491501-1	2011	Water channel aquaporin-4 (AQP4) is expressed in astrocytes throughout brain and spinal cord.	Water	0-5	aquaporin 4	Rattus norvegicus	27-31
21062093-0	2010	Limiting an antimicrobial peptide to the lipid-water interface enhances its bacterial membrane selectivity: a case study of MSI-367.	Water	47-52	RB binding protein 4, chromatin remodeling factor	Homo sapiens	124-127
31506661-4	2019	The C-CoP-1/12 show high electrocatalytic performance for overall water splitting at a low potential of only 1.650 V for the driving current density of 10 mA cm-2, and they exhibit remarkable stability for at least 24 h. The engineering of phosphating is the critical step for the synthesis of pure-phase CoP with hollow nanoarchitecture.	Water	66-71	caspase recruitment domain family member 16	Homo sapiens	6-11
31506661-4	2019	The C-CoP-1/12 show high electrocatalytic performance for overall water splitting at a low potential of only 1.650 V for the driving current density of 10 mA cm-2, and they exhibit remarkable stability for at least 24 h. The engineering of phosphating is the critical step for the synthesis of pure-phase CoP with hollow nanoarchitecture.	Water	66-71	caspase recruitment domain family member 16	Homo sapiens	6-9
31506661-5	2019	Compared with Co2P, CoP possesses lower water dissociation barrier and favorable DeltaGH* value according to theoretical calculations, resulting in superior electrocatalytic performance.	Water	40-45	caspase recruitment domain family member 16	Homo sapiens	20-23
20976343-0	2010	Photochemical and thermal hydrogen production from water catalyzed by carboxylate-bridged dirhodium(II) complexes.	Water	51-56	Rh blood group D antigen	Homo sapiens	100-102
21412259-6	2011	Our study demonstrated that heme oxygenase-1 (HO-1) was the most induced antioxidant gene in PIG1 cells after treatment with H(2)O(2).	Water	125-130	heme oxygenase 1	Homo sapiens	28-44
31451829-1	2019	Two quinoline-malononitrile-based NIR fluorescent probes with good water-solubility have been developed for detecting and imaging of Abeta aggregates in Alzheimer"s disease.	Water	67-72	amyloid beta (A4) precursor protein	Mus musculus	133-138
21412259-6	2011	Our study demonstrated that heme oxygenase-1 (HO-1) was the most induced antioxidant gene in PIG1 cells after treatment with H(2)O(2).	Water	125-130	heme oxygenase 1	Homo sapiens	46-50
31540212-6	2019	The final assay was able to detect octopamine in water within the range 1 nmol L-1-0.1 mol L-1 with a detection limit of 0.047 +- 0.00231 microg mL-1 and in human urine samples within the range 1 nmol L-1-0.0001 mol L-1 with a detection limit of 0.059 +- 0.00281 microg mL-1.	Water	49-54	L1 cell adhesion molecule	Mus musculus	91-94
21531718-4	2011	Consistent with this idea, cysteine-scanning mutagenesis and NMR studies revealed a number of water-accessible residues within TM7 and TM9 of mouse PS1.	Water	94-99	presenilin 1	Mus musculus	148-151
21070066-3	2010	In particular, we show that large atomic basis sets combined with wave function-based methods (such as the MP2 level) have to be preferred to density functional theory when investigating Th(IV)/water aggregates in gas phase.	Water	194-199	tryptase pseudogene 1	Homo sapiens	107-110
21081698-2	2010	CBS catalyzes beta-replacement reactions of either serine or cysteine by homocysteine to give cystathionine and water or H(2)S, respectively.	Water	112-117	Cystathionine beta-synthase	Drosophila melanogaster	0-3
31540212-6	2019	The final assay was able to detect octopamine in water within the range 1 nmol L-1-0.1 mol L-1 with a detection limit of 0.047 +- 0.00231 microg mL-1 and in human urine samples within the range 1 nmol L-1-0.0001 mol L-1 with a detection limit of 0.059 +- 0.00281 microg mL-1.	Water	49-54	L1 cell adhesion molecule	Mus musculus	91-94
21574570-5	2011	In a 10 ns molecular dynamics simulation, one of the buried water molecules in the hCYB5B structure exchanged readily with solvent via intermediates having three water molecules sandwiched between beta4 and beta5.	Water	60-65	adaptor related protein complex 5 subunit beta 1	Homo sapiens	207-212
21574570-6	2011	When the buried water molecules were removed prior to a second 10 ns simulation, beta4 and beta5 formed persistent hydrogen bonds identical to those in rCYB5B, but the Leu21 side chain was forced to adopt a rarely observed conformation.	Water	16-21	adaptor related protein complex 5 subunit beta 1	Homo sapiens	91-96
20926382-9	2010	Consistent with S-glutathionylation, streptavidin pull-down assays with biotinylated glutathione ethyl ester (BioGEE) showed incorporation of GSH to the Kir6.1 subunit in the presence of H(2)O(2).	Water	187-192	potassium inwardly rectifying channel subfamily J member 8	Homo sapiens	153-159
31540212-6	2019	The final assay was able to detect octopamine in water within the range 1 nmol L-1-0.1 mol L-1 with a detection limit of 0.047 +- 0.00231 microg mL-1 and in human urine samples within the range 1 nmol L-1-0.0001 mol L-1 with a detection limit of 0.059 +- 0.00281 microg mL-1.	Water	49-54	L1 cell adhesion molecule	Mus musculus	91-94
31402355-4	2019	Benefiting from its amphiphilicity, the resulting conjugate could act as molecular building blocks to self-assemble into nanoparticles (Ir-YC-1 and Ir-PEG3-YC-1 NPs) in water, which improved the solubility of drugs.	Water	169-174	paternally expressed 3	Homo sapiens	151-155
20525972-0	2010	Carbamazepine can induce kidney water absorption by increasing aquaporin 2 expression.	Water	32-37	aquaporin 2	Homo sapiens	63-74
21506273-4	2011	We show that the displacement of water from specific subpockets (such as S1-4 and the ester binding pocket) of the active site by the ligand can govern potency, especially for cases in which small chemical changes (i.e., a methyl group or halogen) result in a substantial increase in potency.	Water	33-38	ribosomal protein S14	Homo sapiens	73-77
21838142-4	2011	Harmalol in form of salt in water and harmine in form of base and salt in mixture of DMSO and water has the hightest activity on BUCHE.	Water	94-99	butyrylcholinesterase	Homo sapiens	129-134
20973488-0	2010	Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.	Water	27-32	phosphoglycolate phosphatase	Homo sapiens	129-132
31220449-4	2019	Dramatic reduction was found in diuresis, and albuminuria was evident after administration of 1% NaCl in drinking water in Npr2-/- and heterozygous (Npr2+/-) mice compared with their wild-type (Npr2+/+) littermates.	Water	114-119	natriuretic peptide receptor 2	Mus musculus	123-127
21089230-10	2004	have shown that the water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide NPs (Gd-Apoferritin) exhibit 10 and 70 times higher T1 and T2 relaxivity values, respectively, than those of classic Gd(III)-complexes (Omniscan( ) and Gd-DTPA) (8).	Water	20-25	ferritin heavy chain 1	Homo sapiens	34-45
21089230-10	2004	have shown that the water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide NPs (Gd-Apoferritin) exhibit 10 and 70 times higher T1 and T2 relaxivity values, respectively, than those of classic Gd(III)-complexes (Omniscan( ) and Gd-DTPA) (8).	Water	20-25	ferritin heavy chain 1	Homo sapiens	94-105
21089255-10	2004	have shown that the water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide NPs (Gd-Apoferritin) exhibit 10 and 70 times higher T1 and T2 relaxivity values, respectively, than those of classic Gd(III)-complexes (Omniscan( ) and Gd-DTPA) (8).	Water	20-25	ferritin heavy chain 1	Homo sapiens	34-45
21089255-10	2004	have shown that the water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide NPs (Gd-Apoferritin) exhibit 10 and 70 times higher T1 and T2 relaxivity values, respectively, than those of classic Gd(III)-complexes (Omniscan( ) and Gd-DTPA) (8).	Water	20-25	ferritin heavy chain 1	Homo sapiens	94-105
31220449-4	2019	Dramatic reduction was found in diuresis, and albuminuria was evident after administration of 1% NaCl in drinking water in Npr2-/- and heterozygous (Npr2+/-) mice compared with their wild-type (Npr2+/+) littermates.	Water	114-119	natriuretic peptide receptor 2	Mus musculus	149-153
20217159-10	2011	The lowest diffusion coefficient was presented by P60 immersed in distilled water.	Water	76-81	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	50-53
31220449-4	2019	Dramatic reduction was found in diuresis, and albuminuria was evident after administration of 1% NaCl in drinking water in Npr2-/- and heterozygous (Npr2+/-) mice compared with their wild-type (Npr2+/+) littermates.	Water	114-119	natriuretic peptide receptor 2	Mus musculus	149-153
31151008-0	2019	Vertical distribution of perfluoroalkyl substances in water columns around the Japan sea and the Mediterranean Sea.	Water	54-59	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
21793312-3	2011	In our investigation, intracerebroventricular injection of Abeta(25-35) in mice induced the neurodegeneration, exhibited the increased time of escape latency in behavioral pattern using water maze and decreased the levels of antioxidants namley superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and vitamin C with elevated level of acetylcholinesterase enzyme (AChE).	Water	186-191	amyloid beta (A4) precursor protein	Mus musculus	59-64
31286369-5	2019	The present nanocomposite was applied to remove and immobilize Cd2+ from water and soil systems.	Water	73-78	CD2 molecule	Homo sapiens	63-66
21497575-4	2011	These studies reveal the presence of a high affinity binding site for oxidovanadium(IV) in actin, producing local conformational changes near the tryptophans most accessible to water in the three-dimensional structure of actin.	Water	177-182	actin	Oryctolagus cuniculus	91-96
21497575-4	2011	These studies reveal the presence of a high affinity binding site for oxidovanadium(IV) in actin, producing local conformational changes near the tryptophans most accessible to water in the three-dimensional structure of actin.	Water	177-182	actin	Oryctolagus cuniculus	221-226
31475720-6	2019	Lipolysis profiles of polymethoxyflavone (PMF) loaded emulsions suggested that certain heat treatments could reduce the accessibility of lipase towards oil droplets and release of PMFs during lipolysis by enhancing the coverage of granules at the oil-water interface.	Water	251-256	lipase	Zea mays	137-143
31471395-0	2019	Intra-vital Observation of Lung Water Retention Following Intravenous Injection of Anti-MHC-class I (H-2K) Monoclonal Antibody in Mice.	Water	32-37	histocompatibility 2, K1, K region	Mus musculus	101-105
30791139-5	2019	Cooking had a decreasing effect on the T21 relaxation time and its corresponding apparent population (A21 ), corresponding to protein denaturation and water loss during cooking.	Water	151-156	immunoglobulin kappa variable 2-26 (pseudogene)	Homo sapiens	102-105
30791139-6	2019	Increasing the salt concentration to 3% had a protective effect towards water exchange between the A21 and A23 populations in the conventionally washed samples but more subtly in the pH-shift samples.	Water	72-77	immunoglobulin kappa variable 2-26 (pseudogene)	Homo sapiens	99-102
30791139-6	2019	Increasing the salt concentration to 3% had a protective effect towards water exchange between the A21 and A23 populations in the conventionally washed samples but more subtly in the pH-shift samples.	Water	72-77	immunoglobulin kappa variable 2-24	Homo sapiens	107-110
31383344-4	2019	Sodium-glucose cotransporter 2 inhibition by promoting greater electrolyte-free, but glucose driven, water clearance with preferential fluid clearance from the interstitial space, without compromising intravascular volume, may provide symptomatic relief of swelling and bloating.	Water	101-106	solute carrier family 5 member 2	Homo sapiens	0-30
30578654-9	2019	CONCLUSION: Sodium-glucose cotransporter 2 inhibitor DAPA predominantly decreased the ECW with a mild increase in urine volume, but the change in the ECW/total body water was smaller than that in patients treated with FR, and larger than that in patients treated with TLV, suggesting that the effects of SGLT2 inhibitors on fluid distribution may differ from those of conventional diuretics.	Water	165-170	solute carrier family 5 member 2	Homo sapiens	12-42
31299598-6	2019	The activities of phosphoenolpyruvate carboxylase (PEPC), NADP-malic enzyme (NADP-ME), phosphate dikinase (PPDK) and NADP- malic dehydrogenase (NADP-MDH) increased in wheat spike bracts under water deficit.	Water	192-197	phosphoenolpyruvate carboxykinase 1	Homo sapiens	18-49
31444371-7	2019	At baseline, hepsin-deficient mice accumulate uromodulin, along with hyperactivated NKCC2, resulting in a positive sodium balance and a better adaptation to water deprivation.	Water	157-162	uromodulin	Mus musculus	46-56
31027524-6	2019	Colorimetric responses for mir21 and HBV-DNA were obtained at nanomolar concentrations over five orders of magnitudes (from 1 nM to 10 muM), with a limit of detection of ~0.6 nM and ~2 nM in DI water and plasma, respectively.	Water	194-199	microRNA 21	Homo sapiens	27-32
31365247-3	2019	In2(SO4)(TeO3)(OH)2(H2O) crystallized in centrosymmetric (CS) space group P21/n, while In3(SO4)(TeO3)2F3(H2O) formed a non-centrosymmetric (NCS) and chiral space group P212121.	Water	20-23	H3 histone pseudogene 16	Homo sapiens	74-77
30981043-1	2019	The presence and concentrations of 25 antibiotics in Dalian coastal water of the Bohai Sea were investigated using solid-phase extraction coupled with high-performance liquid chromatography tandem mass spectrometry.	Water	68-73	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	87-90
31390991-1	2019	BACKGROUND: Aquaporin (AQP) proteins comprise a group of membrane intrinsic proteins (MIPs) that are responsible for transporting water and other small molecules, which is crucial for plant survival under stress conditions including salt stress.	Water	130-135	Probable aquaporin PIP1-4-like	Cucumis sativus	12-21
31390991-1	2019	BACKGROUND: Aquaporin (AQP) proteins comprise a group of membrane intrinsic proteins (MIPs) that are responsible for transporting water and other small molecules, which is crucial for plant survival under stress conditions including salt stress.	Water	130-135	Probable aquaporin PIP1-4-like	Cucumis sativus	23-26
31178138-6	2019	By the use of genetic approaches, we indicated that Trim47 knockdown significantly reduced the infarct size, mitigated the neurological deficits scores and decreased brain water contents in rats with cerebral I/R injury induced by middle cerebral artery occlusion (MCAO).	Water	172-177	tripartite motif-containing 47	Rattus norvegicus	52-58
31326108-2	2019	We demonstrated the use of terahertz (THz) time-domain spectroscopy to study protein-water interaction of monomeric and dimeric bovine insulin in aqueous samples.	Water	85-90	insulin	Bos taurus	135-142
31034995-5	2019	Our results demonstrated that social housing improved the behavioral performance of APP/PS1 mice in Morris Water Maze testing, without significantly altering the rates of amyloid plaque deposition or amyloidogenic APP processes.	Water	107-112	presenilin 1	Mus musculus	88-91
31051346-5	2019	Additionally, drinking water collected from four regions of Chile showed higher concentrations of bromate (median:18.5 ng mL-1) than the maximum contaminant level (MCL, 10 ng mL-1).	Water	23-28	L1 cell adhesion molecule	Mus musculus	122-126
20961099-4	2010	Two-dimensional correlation spectra show that membrane-bound HNP-1 exhibits a conformation similar to that of the water-soluble state, except for the turn connecting strands beta2 and beta3, whose side chains exhibit immobilization and conformational perturbation upon membrane binding.	Water	114-119	HNP1	Homo sapiens	61-66
30902310-0	2019	Water-soluble vitamins for controlling starch digestion: Conformational scrambling and inhibition mechanism of human pancreatic alpha-amylase by ascorbic acid and folic acid.	Water	0-5	amylase alpha 2A	Homo sapiens	117-141
20688429-1	2010	This study investigates the impact of the type of virgin granular activated carbon (GAC) media used to synthesize iron (hydr)oxide nanoparticle-impregnated granular activated carbon (Fe-GAC) on its properties and its ability to remove arsenate and organic trichloroethylene (TCE) from water.	Water	285-290	glutaminase	Homo sapiens	84-87
20688429-5	2010	Pore surface diffusion model calculations predicted that lignite Fe-GAC could remove ~6.3 L g(-1) dry media and ~4 L g(-1) dry media of water contaminated with 30 mug L(-1) TCE and arsenic, respectively.	Water	136-141	glutaminase	Homo sapiens	68-71
31355400-0	2019	Water-soluble polysaccharides from Grifola Frondosa fruiting bodies protect against immunosuppression in cyclophosphamide-induced mice via JAK2/STAT3/SOCS signal transduction pathways.	Water	0-5	Janus kinase 2	Mus musculus	139-143
20688429-6	2010	In contrast, the bituminous Fe-GAC could remove only ~0.2 L/g dry media for TCE and ~2.8 L/g dry media for As of the same contaminated water.	Water	135-140	glutaminase	Homo sapiens	31-34
20856958-8	2010	We also find that one conserved water has a much stronger interaction with the protein in GluA2, GluK1 and GluK2 compared to the GluN2A receptor.	Water	32-37	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	107-112
31095463-11	2019	The results from this study suggest that DSW could be a potential therapeutic agent for the prevention and treatment of diabetic cardiac hypertrophy.NEW &amp; NOTEWORTHY Deep sea water, containing high levels of minerals, improve cardiac hypertrophy in diabetic rats through attenuating the eccentric signaling pathway, IL-6-MEK5-STAT3, and concentric signaling pathway, IGF2-PKCalpha-CaMKII.	Water	179-184	mitogen activated protein kinase kinase 5	Rattus norvegicus	325-329
31095463-11	2019	The results from this study suggest that DSW could be a potential therapeutic agent for the prevention and treatment of diabetic cardiac hypertrophy.NEW &amp; NOTEWORTHY Deep sea water, containing high levels of minerals, improve cardiac hypertrophy in diabetic rats through attenuating the eccentric signaling pathway, IL-6-MEK5-STAT3, and concentric signaling pathway, IGF2-PKCalpha-CaMKII.	Water	179-184	signal transducer and activator of transcription 3	Rattus norvegicus	330-335
20923173-12	2010	In all Mg2+ binding motifs, a key hydrogen bond was identified between a magnesium-bound water and Cys1p, bridging the two metallic binding sites and, thereby, reducing the equilibrium distance between the reacting atoms of FPP Cys1p.	Water	89-94	cystin 1	Homo sapiens	99-104
21430273-7	2011	For neurons ipsilateral to dry skin treatment, responses elicited by the PAR-2 agonist, but not histamine or mechanical stimuli, were significantly larger compared with neurons ipsilateral to vehicle (water) treatment or neurons recorded in naive (untreated) mice.	Water	201-206	pulmonary adenoma resistance 2	Mus musculus	73-78
20923173-12	2010	In all Mg2+ binding motifs, a key hydrogen bond was identified between a magnesium-bound water and Cys1p, bridging the two metallic binding sites and, thereby, reducing the equilibrium distance between the reacting atoms of FPP Cys1p.	Water	89-94	cystin 1	Homo sapiens	228-233
31262165-5	2019	The good performance is ascribed to plentiful active sites on the heterointerface of MoP/MoS2 for activating H2O, good conductivity of MoP and CC for electron transfer, and pores surrounded by MoP/MoS2 facilitating mass transfer as shown by XPS and density functional theory calculations.	Water	109-112	opioid receptor mu 1	Homo sapiens	85-88
20856955-4	2010	The MP2/CBS calculated binding energies of different complexes between the halogenated ethers and water vary between 1.7 and 7.7 kcal mol(-1).	Water	98-103	tryptase pseudogene 1	Homo sapiens	4-7
21849817-2	2011	The molecular mechanism of AVP1-mediated drought resistance is likely due to increased proton pump activity of the vacuolar pyrophosphatase, which generates a higher proton electrochemical gradient across the vacuolar membrane, leading to lower water potential in the plant vacuole and higher secondary transporter activities that prevent ion accumulation to toxic levels in the cytoplasm.	Water	245-250	Inorganic H pyrophosphatase family protein	Arabidopsis thaliana	27-31
31127001-4	2019	In particular, DAGL-alpha-/- mice display profound impairments in the Object Location assay and Morris Water Maze (MWM) acquisition engaging in nonspatial search strategies.	Water	103-108	diacylglycerol lipase, alpha	Mus musculus	15-25
21713710-8	2011	CONCLUSIONS: Expression of aquaporin 3 in the proximal colon of STC rat models is down-regulated, which regulates water absorption.	Water	114-119	aquaporin 3 (Gill blood group)	Rattus norvegicus	27-38
20920470-5	2010	Western blot and immunohistochemical analyses revealed that Ly6k exists in at least two forms: a GPI-anchored form (17kDa) and a water-soluble (non-membrane) form (12kDa), and the 17-kDa mature form is expressed in the testicular germ cells beginning approximately 10days after birth.	Water	129-134	lymphocyte antigen 6 complex, locus K	Mus musculus	60-64
31127001-7	2019	These novel behavioral and electrophysiological results implicate a direct and perhaps selective role of DAGL-alpha in the integration of new spatial information.SIGNIFICANCE STATEMENT Here we show that genetic deletion or pharmacologic inhibition of diacylglycerol lipase-alpha (DAGL-alpha) impairs hippocampal CA1 LTP, differentially disrupts spatial learning and memory performance in Morris water maze (MWM) and Object Location tasks, and alters brain levels of endocannabinoids and related lipids.	Water	395-400	diacylglycerol lipase, alpha	Mus musculus	105-115
20882961-2	2010	The use of the MP2 method and correlation consistent basis sets, with appropriate correction for BSSE, allows for the accurate calculation of electronic and free energies for the formation of clusters of 2-10 water molecules.	Water	209-214	tryptase pseudogene 1	Homo sapiens	15-18
31460366-1	2019	Engineering of water-dispersible Gd3+ ions-decorated reduced graphene oxide (Gd-rGO) nanosheets (NSs) has been performed.	Water	15-20	GRDX	Homo sapiens	33-36
20701960-11	2010	The 1-SEa and the 2-SEa performed significantly lower in muTFR than the 3-E&amp;Ra, when tested at 2Hz after 3-month water storage.	Water	117-122	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	20-23
31272168-7	2019	GT1 is weakly pressure-dependent, 12 K GPa-1, with a relaxation time of 0.3 s at 140 K and 1 GPa; it is associated with a weak heat capacity increase of 3.7 J H2O-mol-1 K-1 in a 18 K range and an activation energy of only 38 kJ mol-1 at 1 GPa.	Water	159-162	beta-1,4-galactosyltransferase 1	Homo sapiens	0-3
21029429-13	2010	U-AQP2 decreased indicating that water transport via AQP2 fell.	Water	33-38	aquaporin 2	Homo sapiens	2-6
21029429-13	2010	U-AQP2 decreased indicating that water transport via AQP2 fell.	Water	33-38	aquaporin 2	Homo sapiens	53-57
21451883-0	2011	[Gd(Try-TTDA)(H2O)]2-: a new MRI contrast agent for copper ion sensing.	Water	14-17	general transcription factor IIH subunit 5	Homo sapiens	8-12
21251236-8	2011	Accordingly, the water intake was significantly smaller and saline intake was significantly larger in sgk1(+/+) mice than in sgk1(-/-) mice and the preference for water was significantly stronger in sgk1(-/-) mice than in sgk1(+/+) mice.	Water	163-168	serum/glucocorticoid regulated kinase 1	Mus musculus	125-129
21251236-8	2011	Accordingly, the water intake was significantly smaller and saline intake was significantly larger in sgk1(+/+) mice than in sgk1(-/-) mice and the preference for water was significantly stronger in sgk1(-/-) mice than in sgk1(+/+) mice.	Water	163-168	serum/glucocorticoid regulated kinase 1	Mus musculus	125-129
31284689-5	2019	The physiology section will highlight the molecular strength and significance of aquaporin-2 (AQP2) water channel downregulation, in response to chronic anti-diuretic hormone suppression.	Water	100-105	aquaporin 2	Homo sapiens	81-92
21251236-8	2011	Accordingly, the water intake was significantly smaller and saline intake was significantly larger in sgk1(+/+) mice than in sgk1(-/-) mice and the preference for water was significantly stronger in sgk1(-/-) mice than in sgk1(+/+) mice.	Water	163-168	serum/glucocorticoid regulated kinase 1	Mus musculus	125-129
21451971-3	2011	Aquaporin-1 (AQP-1) is a transmembrane channel protein that is permeable to water and O(2), which prevents rapid volume deformation under osmotic stress and facilitates O(2) diffusion across the plasma membrane.	Water	76-81	aquaporin-1	Oryctolagus cuniculus	0-11
21451971-3	2011	Aquaporin-1 (AQP-1) is a transmembrane channel protein that is permeable to water and O(2), which prevents rapid volume deformation under osmotic stress and facilitates O(2) diffusion across the plasma membrane.	Water	76-81	aquaporin-1	Oryctolagus cuniculus	13-18
20981096-2	2010	The ratio of phosphorus to iron in iron-oxide-rich sedimentary rocks can be used to track dissolved phosphate concentrations if the dissolved silica concentration of sea water is estimated.	Water	170-175	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	166-169
20820533-1	2010	The interaction of a tetracationic calixarene (TAC4) with dianionic guest (BS) in water was studied with NMR, nano-ITC and ESI-MS experiments; the convergent evidence provided by these different techniques shows that the addition of a suitable guest molecule triggers the formation of a homodimeric capsule in aqueous neutral solution.	Water	82-87	tachykinin precursor 4	Homo sapiens	47-51
31284689-5	2019	The physiology section will highlight the molecular strength and significance of aquaporin-2 (AQP2) water channel downregulation, in response to chronic anti-diuretic hormone suppression.	Water	100-105	aquaporin 2	Homo sapiens	94-98
31244122-2	2019	In sum, we characterized two modes of bonding of [Zn2+-Tz] with CO2/H2O: the interaction is established through (i) a covalent bond between Zn2+ of [Zn2+-Tz] and oxygen atoms of CO2 or H2O and (ii) hydrogen bonds through N-H or C-H of [Zn2+-Tz] and oxygen atoms of H2O or CO2, N-H   O.	Water	185-188	complement C2	Homo sapiens	64-71
20950000-1	2010	A computational study of hydrogen-bonded complexes of F(3)CH and C1H and of lithium-bonded complexes of F(3)CLi and CILi, with small molecules such as N(2) and H(2)O was undertaken at the MP2/6-311++G(d,p) level of theory.	Water	160-165	tryptase pseudogene 1	Homo sapiens	188-191
20947024-4	2010	Both RRM1 in RRM1-RNA and RRM2 in RRM1/2-RNA complexes use similar principles to target UGU(U/G) elements, with recognition mediated by face-to-edge stacking and water-mediated hydrogen-bonding networks.	Water	162-167	ribonucleotide reductase regulatory subunit M2	Homo sapiens	26-30
21530758-13	2011	The experimental cement (TP2) absorbed significantly more water than the control group (P&lt;.034).	Water	58-63	transition protein 2	Homo sapiens	25-28
31023843-7	2019	The distilled water C2 and C5 thresholds increased significantly (p&lt;0.001) by a factor of 1.4 and 1.3, respectively, in CC patients.	Water	14-19	complement C2	Homo sapiens	20-22
21845871-6	2011	In model group and control with sterile water for injection group, the level of Bcl-2, Bax expression peaked at 3 d after hypoxic-ischemic brain damage (HIBD) (P &lt; 0.05 vs other groups), the value of neuronal density (ND) was decreased, and histological grade (HG) was increased compared with that in the sham group (P &lt; 0.05).	Water	40-45	BCL2 associated X, apoptosis regulator	Rattus norvegicus	87-90
20619889-3	2010	The resulting Ab(2)-PEG-PLA-Fe(3)O(4) demonstrated high catalytic activity towards H(2)O(2), and the sensitivity of the sandwich-type immunosensor using this label for prostate specific antigen (PSA) detection increased greatly.	Water	83-88	kallikrein related peptidase 3	Homo sapiens	168-193
31737417-7	2019	In vivo the open wound rate in the MPO group was significantly lower, while the contraction rate and epithelialization rate of MPO group were higher than that of the control group, NaCl+H2O2 group, and NeutroPhase group on day 20.	Water	186-190	myeloperoxidase	Rattus norvegicus	127-130
20423075-2	2010	Both powdered and immobilized Pt/CdS/TiO(2) photocatalysts were used to oxidize model inorganic (S(2-)/SO(3)(2-)) and organic (ethanol) sacrificial agents/pollutants in water.	Water	169-174	CDP-diacylglycerol synthase 1	Homo sapiens	33-36
21463006-4	2011	The finite element method reveals that the electrostatic field generated by LiF molecules plays a unique role in achieving the gating of the water SWCNT.	Water	141-146	LIF interleukin 6 family cytokine	Homo sapiens	76-79
31090073-6	2019	The values of LOQs in tap water (0.006-0.0074 microg/mL) were much lower than the maximum permissible concentrations of 2,4,6-TCP, 2,4-DCP, and 2-CP in drinking water stipulated by World Health Organization (WHO) namely 0.3, 0.04, and 0.01 microg/mL, respectively, and thereby the method was suitable to detect the CPs according to WHO guidelines.	Water	26-31	TARBP2 subunit of RISC loading complex	Homo sapiens	14-18
21276418-1	2011	Aquaporin 3 (AQP3) is an aquaglyceroporin that transports water and glycerol and is expressed in the epidermis, among other epithelial tissues.	Water	58-63	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
21276418-1	2011	Aquaporin 3 (AQP3) is an aquaglyceroporin that transports water and glycerol and is expressed in the epidermis, among other epithelial tissues.	Water	58-63	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
21425816-1	2011	For the first time, a systematic investigation of the glass transition and its related dynamics of myoglobin in water-glycerol solvent mixtures of different water contents is presented.	Water	112-117	myoglobin	Homo sapiens	99-108
21347573-1	2011	Aquaporin-4 (AQP4), a member of the water channel family, has high water permeability and multi-functional potentiality.	Water	67-72	aquaporin 4	Gallus gallus	13-17
21137404-0	2010	[Preliminary investigation on the formation mechanism of CCL4-water-cetyl trimethyl ammonium bromide (CTAB) gel].	Water	62-67	C-C motif chemokine ligand 4	Homo sapiens	57-61
20935394-4	2010	MATERIALS AND METHODS: We prospectively compared two techniques for decontamination of laryngoscope blades - a) washing with tap-water and b) washing with tap-water followed by disinfection by immersing in 5% v/v (volume/volume, 1:20 dilution) aldehyde-free biguanide agent for 10 min.	Water	159-164	filamin B	Homo sapiens	155-158
31090073-6	2019	The values of LOQs in tap water (0.006-0.0074 microg/mL) were much lower than the maximum permissible concentrations of 2,4,6-TCP, 2,4-DCP, and 2-CP in drinking water stipulated by World Health Organization (WHO) namely 0.3, 0.04, and 0.01 microg/mL, respectively, and thereby the method was suitable to detect the CPs according to WHO guidelines.	Water	161-166	TARBP2 subunit of RISC loading complex	Homo sapiens	14-18
31120762-5	2019	In the absence of an excipient, the unstirred water layer (UWL) adjacent to the GI membrane was found to hinder the permeability of the drug, accounting for this UWL effect and revealing that the true membrane permeability allowed good prediction of the solubility-permeability trade-off as a function of EPO level using a direct relationship between the increased solubility afforded by a given EPO level and the consequent decreased permeability.	Water	46-51	erythropoietin	Rattus norvegicus	305-308
20535623-3	2011	To address the problem of the differences in the mechanism of the cap recognition by those highly homologic proteins, we carried out molecular dynamics simulations in water of three factors, IFE-3 and IFE-5 isoforms from C. elegans and murine eIF4E, in the apo form as well as in the complexes with 7-methyl-GDP and N(2),N(2),7-trimethyl-GDP.	Water	167-172	Eukaryotic translation initiation factor 4E-5	Caenorhabditis elegans	201-206
31120762-5	2019	In the absence of an excipient, the unstirred water layer (UWL) adjacent to the GI membrane was found to hinder the permeability of the drug, accounting for this UWL effect and revealing that the true membrane permeability allowed good prediction of the solubility-permeability trade-off as a function of EPO level using a direct relationship between the increased solubility afforded by a given EPO level and the consequent decreased permeability.	Water	46-51	erythropoietin	Rattus norvegicus	396-399
31247935-0	2019	Experimental Study on the Effects of Vegetation on the Dissipation of Supersaturated Total Dissolved Gas in Flowing Water.	Water	116-121	gastrin	Homo sapiens	101-104
21148409-1	2011	Vasopressin-induced water reabsorption coincides with phosphorylation of aquaporin-2 (AQP2) at S256 (pS256), dephosphorylation at S261, and its translocation to the apical membrane, whereas treatment with the phorbol ester 12-tetradecanoylphorbol-13-acetate (TPA) induces AQP2 ubiquitination at K270, its internalization, and lysosomal degradation.	Water	20-25	aquaporin 2	Canis lupus familiaris	272-276
31230150-5	2019	Under optimized conditions, response to phenylurea herbicides is linear in the 2.0-100 ng mL-1 concentration range for water samples, and 5.0-100 ng g-1 for leaf lettuces.	Water	119-124	L1 cell adhesion molecule	Mus musculus	90-94
20132410-2	2011	The G(alphao) -mediated water channel aquaporin-6 (AQP-6) involvement in synaptic vesicle (SV) swelling in neurons has previously been reported.	Water	24-29	aquaporin 6	Homo sapiens	38-49
31230150-6	2019	The limits of detection are 0.10-0.25 ng mL-1 for water samples, and 1.5-2.5 ng g-1 for leaf lettuces.	Water	50-55	L1 cell adhesion molecule	Mus musculus	41-45
20132410-2	2011	The G(alphao) -mediated water channel aquaporin-6 (AQP-6) involvement in synaptic vesicle (SV) swelling in neurons has previously been reported.	Water	24-29	aquaporin 6	Homo sapiens	51-56
31018430-0	2019	Interaction between functionalized multiwalled carbon nanotubes and MS2 bacteriophages in water.	Water	90-95	MS2	Homo sapiens	68-71
21185908-4	2011	Around the ribbon synapses in this layer, AQP6 labeling was co-localized with the glial water channel AQP4.	Water	88-93	aquaporin 4	Rattus norvegicus	102-106
31018440-4	2019	At early experimental period, the sharp decrease of dissolved organic nutrients and the abundant production of leucine aminopeptidase (LAP) and alkaline phosphatase (AP) in correspondence with high phytoplankton abundance in bottom and interstitial water reflected the relevance of organic nutrients for inorganic nutrients regeneration and phytoplankton growth.	Water	249-254	LAP	Homo sapiens	111-133
31091080-9	2019	Electrode-supported Co-Black TNT facilitates the recovery of the catalyst from the treated water.	Water	91-96	troponin T1, slow skeletal type	Homo sapiens	29-32
32938036-9	2011	The proposed method was evaluated with real water samples spiked at a concentration of 10 ng mL-1 and good spiked recoveries over the range of 89.2~102.7% were obtained.	Water	44-49	L1 cell adhesion molecule	Mus musculus	93-97
31212909-0	2019	A Combined Barite-Ilmenite Weighting Material to Prevent Barite Sag in Water-Based Drilling Fluid.	Water	71-76	S-antigen visual arrestin	Homo sapiens	64-67
31212909-4	2019	This study introduces a combined barite-ilmenite weighting material to prevent the barite sag problem in water-based drilling fluid.	Water	105-110	S-antigen visual arrestin	Homo sapiens	90-93
20628403-1	2011	Cerebral atrial natriuretic peptide (ANP), which is generated in the brain, has functions in the regulation of brain water and electrolyte balance, blood pressure and local cerebral blood flow, as well as in neuroendocrine functions.	Water	117-122	natriuretic peptide type A	Mus musculus	9-35
33267260-5	2019	Moreover, the cycle"s COP and exergy efficiency with CaCl2-LiNO3-KNO3(15.5:5:1)/H2O were approximately 0.04 and 0.06 higher than those with LiBr/H2O, respectively.	Water	80-83	caspase recruitment domain family member 16	Homo sapiens	22-25
33267260-5	2019	Moreover, the cycle"s COP and exergy efficiency with CaCl2-LiNO3-KNO3(15.5:5:1)/H2O were approximately 0.04 and 0.06 higher than those with LiBr/H2O, respectively.	Water	145-148	caspase recruitment domain family member 16	Homo sapiens	22-25
20558011-0	2011	Enhanced water-holding capacity of meat was associated with increased Sepw1 gene expression in pigs fed selenium-enriched yeast.	Water	9-14	selenoprotein W	Sus scrofa	70-75
20558011-6	2011	These suggested that the enhanced water-holding capacity of meat was associated with the increased expression of Sepw1 gene.	Water	34-39	selenoprotein W	Sus scrofa	113-118
31275372-10	2019	PPIA quantitation of MC-LA in water agreed with liquid chromatography high resolution mass spectrometry (LC/HRMS), whereas the ELISA quantitation did not agree with LC/HRMS quantitation.	Water	30-35	peptidylprolyl isomerase A	Homo sapiens	0-4
21408051-4	2011	The stress hormone ABA (abscisic acid) was present at high levels in esk1 compared to wild type, nevertheless, the weak water loss of esk1 was independent of stomata closure through ABA biosynthesis, as combining mutant in this pathway with esk1 led to additive phenotypes.	Water	120-125	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	134-138
21408051-4	2011	The stress hormone ABA (abscisic acid) was present at high levels in esk1 compared to wild type, nevertheless, the weak water loss of esk1 was independent of stomata closure through ABA biosynthesis, as combining mutant in this pathway with esk1 led to additive phenotypes.	Water	120-125	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	134-138
21408051-5	2011	Measurement of root hydraulic conductivity suggests that the esk1 vegetative apparatus suffers water deficit due to a defect in water transport.	Water	95-100	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	61-65
21408051-6	2011	ESK1 promoter-driven reporter gene expression was observed in xylem and fibers, the vascular tissue responsible for the transport of water and mineral nutrients from the soil to the shoots, via the roots.	Water	133-138	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	0-4
31108848-4	2019	The results indicate that agglomerative accumulation is formed in the voids of mortar after water desorption from SAP and there are abundant hydration products, most of which are C-S-H gels, around the SAP voids.	Water	92-97	amyloid P component, serum	Homo sapiens	114-117
31108848-6	2019	At a dosage of 0.1% SAP and an entrained water-cement ratio of 0.06, the powdery SAP and the swelled SAP can reduce the mortar shrinkage rate by about 32.2% and 14.5%, respectively.	Water	41-46	amyloid P component, serum	Homo sapiens	81-84
31108848-6	2019	At a dosage of 0.1% SAP and an entrained water-cement ratio of 0.06, the powdery SAP and the swelled SAP can reduce the mortar shrinkage rate by about 32.2% and 14.5%, respectively.	Water	41-46	amyloid P component, serum	Homo sapiens	81-84
31108848-8	2019	In particular, for powdery SAP with an entrained water-to-cement ratio of 0.06, the mass loss rate after 300 cycles is still lower than 5%.	Water	49-54	amyloid P component, serum	Homo sapiens	27-30
20572157-4	2011	Recently, we demonstrated water maze training-induced increases in tissue levels of agmatine in the CA1 subregion of the hippocampus.	Water	26-31	carbonic anhydrase 1	Rattus norvegicus	100-103
30109550-12	2019	In conclusion, it could be inferred that long-term arsenic exposure via drinking water leads to brain arsenic accumulation with serum S100B elevated concentration as a probable BBB disruption consequence.	Water	81-86	S100 protein, beta polypeptide, neural	Mus musculus	134-139
21103475-0	2011	Effects of counterpoise correction and basis set extrapolation on the MP2 geometries of hydrogen bonded dimers of ammonia, water, and hydrogen fluoride.	Water	123-128	tryptase pseudogene 1	Homo sapiens	70-73
31289660-2	2019	Experimental results showed that with increased levels of curdlan, the water-holding capacity, gel strength, and storage modulus of a myosin gel first increased and then decreased.	Water	71-76	myosin heavy chain 14	Homo sapiens	134-140
21162566-8	2011	Differences in the quenching rate constants of the triplet by water and phenols suggest a strong hydrogen-bond interaction with the nitro group in the C-2 position, which provides for radiationless deactivation routes.	Water	62-67	complement C2	Homo sapiens	151-154
20980265-9	2011	Here, we describe Na(+)-coupled I(-) uptake by the human Na(+)/multivitamin transporter (hSMVT), a related protein isolated from the placenta, where it was suggested to supply the fetus with the water-soluble vitamins biotin and pantothenic acid, and alpha-lipoic acid.	Water	195-200	solute carrier family 5 member 6	Homo sapiens	89-94
21893986-8	2011	In this article, the molecular biology of ET-1 and its receptors in the control of renal vasculature tonicity, glomerular function, and management of water and salt reabsorption is discussed.	Water	150-155	endothelin 1	Mus musculus	42-46
21893992-3	2011	A large number of in vitro studies have supported this notion of an autocrine function for ET-1, demonstrating that the peptide, largely through activation of the ET(B) receptor, inhibits both sodium (Na) and water reabsorption in the CD.	Water	209-214	endothelin 1	Mus musculus	91-95
21893992-7	2011	The mechanisms by which ET-1 exerts its effects on CD Na and water reabsorption are being increasingly understood.	Water	61-66	endothelin 1	Mus musculus	24-28
21893992-10	2011	ET-1 reduces CD water reabsorption by inhibition of vasopressin-stimulated adenylyl cyclase activity through G(i) and protein kinase C-dependent pathways, leading to a reduction in cellular cAMP levels.	Water	16-21	endothelin 1	Mus musculus	0-4
20849844-5	2011	Blue-Native polyacrylamide gel electrophoresis showed that higher order oligomers typical to the AQP4 water channel were present in both membrane compartments.	Water	102-107	aquaporin 4	Rattus norvegicus	97-101
20849844-8	2011	Taken together, our results strongly suggest that both the sarcolemma and the T tubules harbor higher order oligomers of the AQP4 water channel but the interactions with adjacent macromolecules are different.	Water	130-135	aquaporin 4	Rattus norvegicus	125-129
21059177-0	2011	Spatially differing bacterial communities in water columns of the northern Baltic Sea.	Water	45-50	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	82-85
22129735-8	2011	Immunochemical staining revealed that the AhR and CYP1A2 positive signals were enhanced, and the ARNT positive signal was weakened in the uteri of mice drinking water with TCDD (2 ng/l) and the canal water samples.	Water	161-166	aryl hydrocarbon receptor nuclear translocator	Mus musculus	97-101
22129735-8	2011	Immunochemical staining revealed that the AhR and CYP1A2 positive signals were enhanced, and the ARNT positive signal was weakened in the uteri of mice drinking water with TCDD (2 ng/l) and the canal water samples.	Water	200-205	aryl hydrocarbon receptor nuclear translocator	Mus musculus	97-101
20940332-4	2011	regulation of renal water excretion) by regulating the water channel aquaporin-2 in collecting duct cells.	Water	20-25	aquaporin 2	Homo sapiens	69-80
20940332-12	2011	The latter suggests that long-term regulatory processes may contribute to actomyosin-dependent trafficking of the water channel aquaporin-2.	Water	114-119	aquaporin 2	Homo sapiens	128-139
21378744-1	2011	The present clinical study had the objective to evaluate the role of a hypertonic solution of sterile water from the Adriatic Sea in the prevention and treatment of chronic adenoiditis in children.	Water	102-107	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	126-129
20971851-0	2010	Phosphorylation of aquaporin-2 regulates its water permeability.	Water	45-50	aquaporin 2	Homo sapiens	19-30
20971851-1	2010	Vasopressin-regulated water reabsorption through the water channel aquaporin-2 (AQP2) in renal collecting ducts maintains body water homeostasis.	Water	22-27	aquaporin 2	Homo sapiens	53-78
20971851-1	2010	Vasopressin-regulated water reabsorption through the water channel aquaporin-2 (AQP2) in renal collecting ducts maintains body water homeostasis.	Water	22-27	aquaporin 2	Homo sapiens	80-84
20971851-1	2010	Vasopressin-regulated water reabsorption through the water channel aquaporin-2 (AQP2) in renal collecting ducts maintains body water homeostasis.	Water	53-58	aquaporin 2	Homo sapiens	80-84
20971851-2	2010	Vasopressin activates PKA, which phosphorylates AQP2, and this phosphorylation event is required to increase the water permeability and water reabsorption of the collecting duct cells.	Water	113-118	aquaporin 2	Homo sapiens	48-52
20971851-2	2010	Vasopressin activates PKA, which phosphorylates AQP2, and this phosphorylation event is required to increase the water permeability and water reabsorption of the collecting duct cells.	Water	136-141	aquaporin 2	Homo sapiens	48-52
20971851-3	2010	It has been established that the phosphorylation of AQP2 induces its apical membrane insertion, rendering the cell water-permeable.	Water	115-120	aquaporin 2	Homo sapiens	52-56
20971851-8	2010	PKA phosphorylation significantly increased the osmotic water permeability of AQP2-reconstituted liposomes.	Water	56-61	aquaporin 2	Homo sapiens	78-82
20971851-10	2010	The water permeability of the non-phosphorylation-mimicking mutant S256A-AQP2 and non-phosphorylated WT-AQP2 was similar, and that of the phosphorylation-mimicking mutant S256D-AQP2 and phosphorylated WT-AQP2 was similar.	Water	4-9	aquaporin 2	Homo sapiens	73-77
20971851-11	2010	The water permeability of S261A-AQP2 and S261D-AQP2 was similar to that of non-phosphorylated WT-AQP2.	Water	4-9	aquaporin 2	Homo sapiens	32-36
20971851-11	2010	The water permeability of S261A-AQP2 and S261D-AQP2 was similar to that of non-phosphorylated WT-AQP2.	Water	4-9	aquaporin 2	Homo sapiens	47-51
20971851-11	2010	The water permeability of S261A-AQP2 and S261D-AQP2 was similar to that of non-phosphorylated WT-AQP2.	Water	4-9	aquaporin 2	Homo sapiens	47-51
20971851-12	2010	This study shows that PKA phosphorylation of AQP2 at Ser-256 enhances its water permeability.	Water	74-79	aquaporin 2	Homo sapiens	45-49
21123876-6	2010	In addition, the structure of the FOXO4-DBD-DNA complex suggests that both direct water-DNA base contacts and the unique water-network interactions contribute to FOXO-DBD binding to the DNA in a sequence-specific manner.	Water	82-87	forkhead box O4	Homo sapiens	34-39
21123876-6	2010	In addition, the structure of the FOXO4-DBD-DNA complex suggests that both direct water-DNA base contacts and the unique water-network interactions contribute to FOXO-DBD binding to the DNA in a sequence-specific manner.	Water	121-126	forkhead box O4	Homo sapiens	34-39
21112289-3	2010	Here we show that the renal potassium-chloride-cotransporter (KCC1) does not pump a fixed amount of water molecules per movement of one K(+) and one Cl(-), as was reported for the analogous transporter in the choroid plexus.	Water	100-105	solute carrier family 12 member 4	Homo sapiens	62-66
21112289-6	2010	KCC1 inhibition reduced epithelial osmotic water permeability P(f) by roughly one-third, i.e., the effect of inhibitors was small in resting cells and substantial in hormonal stimulated cells that contained high concentrations of aquaporin-2 in their apical membranes.	Water	43-48	solute carrier family 12 member 4	Homo sapiens	0-4
21112289-7	2010	The furosemide or DIOA (dihydroindenyl-oxy-alkanoic acid)-sensitive water flux was much larger than expected when water passively followed the KCC1-mediated ion flow.	Water	68-73	solute carrier family 12 member 4	Homo sapiens	143-147
21112289-7	2010	The furosemide or DIOA (dihydroindenyl-oxy-alkanoic acid)-sensitive water flux was much larger than expected when water passively followed the KCC1-mediated ion flow.	Water	114-119	solute carrier family 12 member 4	Homo sapiens	143-147
21112289-8	2010	The inhibitory effect of these drugs on water flux was reversed by the K(+)-H(+) exchanger nigericin, indicating that KCC1 affects water transport solely by K(+) extrusion.	Water	40-45	solute carrier family 12 member 4	Homo sapiens	118-122
21112289-8	2010	The inhibitory effect of these drugs on water flux was reversed by the K(+)-H(+) exchanger nigericin, indicating that KCC1 affects water transport solely by K(+) extrusion.	Water	131-136	solute carrier family 12 member 4	Homo sapiens	118-122
20734059-5	2010	Moreover, immunoblotting analysis revealed an increase in aquaporin-4 (AQP4) water channel and an alteration of proteins belonging to the dystrophin-glycoprotein complex (DGC).	Water	77-82	aquaporin 4	Rattus norvegicus	58-69
20734059-5	2010	Moreover, immunoblotting analysis revealed an increase in aquaporin-4 (AQP4) water channel and an alteration of proteins belonging to the dystrophin-glycoprotein complex (DGC).	Water	77-82	aquaporin 4	Rattus norvegicus	71-75
20933385-3	2010	In an attempt to improve both the water solubility and tumour-targeting properties of paclitaxel (Taxol ), we set out to develop a water soluble paclitaxel prodrug that is activated specifically by prostate-specific antigen (PSA) which is almost exclusively expressed in prostate tissue and prostate carcinoma making it an ideal molecular target for prodrug strategies.	Water	34-39	kallikrein related peptidase 3	Homo sapiens	198-229
20933385-3	2010	In an attempt to improve both the water solubility and tumour-targeting properties of paclitaxel (Taxol ), we set out to develop a water soluble paclitaxel prodrug that is activated specifically by prostate-specific antigen (PSA) which is almost exclusively expressed in prostate tissue and prostate carcinoma making it an ideal molecular target for prodrug strategies.	Water	131-136	kallikrein related peptidase 3	Homo sapiens	198-229
20882523-6	2010	Further application of compression causes the appearance of dark areas in the OCT images obtained, likely associated with interstitial or intracellular water inflow to the observed region.	Water	152-157	plexin A2	Homo sapiens	78-81
21047120-10	2010	The 1.8 A resolution crystal structure of DCoH1 T51S shows the presence of an ordered water molecule at the tetramer interface, as in DCoH2, which may destabilize the homotetramer.	Water	86-91	pterin-4 alpha-carbinolamine dehydratase 2	Homo sapiens	134-139
20971073-6	2010	Corresponding changes in Ca(2+) transients are observed in MsrA(-/-) cardiomyocytes treated with 2Hz stimulation or with H(2)O(2).	Water	121-126	methionine sulfoxide reductase A	Mus musculus	59-63
21038904-3	2010	More than 200 cluster structures with water were analyzed by B3LYP and MP2 quantum chemical methods.	Water	38-43	tryptase pseudogene 1	Homo sapiens	71-74
20484841-9	2010	These results suggest that AQP4, which is expressed in FS cells, in marginal layer cells and in pituicytes, but not in hormone-producing cells, is important in water transfer within the pituitary gland; astrocytes and ependymal cells do the same in the brain.	Water	160-165	aquaporin 4	Rattus norvegicus	27-31
20812736-6	2010	These properties make mitoNEET potentially useful for both physiological studies and industrial applications as a stable, water-soluble, redox agent.	Water	122-127	CDGSH iron sulfur domain 1	Homo sapiens	22-30
20599910-9	2010	Consistently, DHT also significantly inhibit the expression of caspase-3, caspase-9 and phospho p38 MAPK induced by H(2)O(2).	Water	116-121	caspase 9	Homo sapiens	74-83
20620148-6	2010	The NbSyn2:alpha-synuclein interaction is mediated mainly by side-chain interactions while water molecules cross-link the main-chain atoms of alpha-synuclein to atoms of NbSyn2, a feature we believe could be important in intrinsically disordered protein interactions more generally.	Water	91-96	synuclein alpha	Homo sapiens	142-157
20541453-7	2010	H(6)L was found suitable as a new reagent for the separation and preconcentration of ZrO(2+) ions from different water samples using flotation technique with satisfactory results.	Water	113-118	H6 family homeobox 2	Homo sapiens	0-5
20707311-11	2010	The longer CoB(8)SH and CoB(9)SH analogues can be accommodated in the active site through exclusion of this water.	Water	108-113	metabolism of cobalamin associated B	Homo sapiens	11-14
20707311-11	2010	The longer CoB(8)SH and CoB(9)SH analogues can be accommodated in the active site through exclusion of this water.	Water	108-113	metabolism of cobalamin associated B	Homo sapiens	24-27
20681536-5	2010	Following this result, various water solvation structures of the valence-bound CH(3)NO(2)(-) anion were optimized with up to six water solvents using the second-order Moller-Plesset (MP2) method.	Water	31-36	tryptase pseudogene 1	Homo sapiens	183-186
20576681-6	2010	Time course studies in rat IMCD suspensions showed maximum phosphorylation within 1 min of dDAVP exposure, consistent with the time course of vasopressin-stimulated phosphorylation of the vasopressin-sensitive water channel aquaporin-2 at Ser256.	Water	210-215	aquaporin 2	Rattus norvegicus	224-235
19685273-4	2010	The detection limit of copper in water and soil is 2 ng mL(-1) and 4 ng g(-1), respectively.	Water	33-38	L1 cell adhesion molecule	Mus musculus	56-68
20553906-10	2010	EGCG significantly inhibited telomere attrition, TRF(2) loss and p53, p21 upregulation induced by H(2)O(2).	Water	98-103	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	65-68
20631022-9	2010	Water loading was followed by a very slow and incomplete elimination in the asymptomatic hemizygous boy with no suppression of AQP2 excretion and a delayed elimination in the heterozygous women because of an incomplete suppression of AQP2, and it induced hyponatremia in all NSIAD patients.	Water	0-5	aquaporin 2	Homo sapiens	234-238
20648652-8	2010	Administration of N-acetyl-L-cysteine (NAC), a glutathione precursor, to APP/PS-1 mice via drinking water suppressed increased protein oxidation and nitration and also significantly augmented levels and activity of GPx in brain from both age groups.	Water	100-105	presenilin 1	Mus musculus	77-81
20589640-8	2010	We propose that the fast k(on) and entropically driven thermodynamics observed for PCSK9-EGF-A binding stem from the functional replacement of water occupying stable PCSK9 hydration sites (i.e., exchange of PCSK9 H-bonds from water to polar EGF-A groups).	Water	143-148	proprotein convertase subtilisin/kexin type 9	Homo sapiens	83-88
20589640-8	2010	We propose that the fast k(on) and entropically driven thermodynamics observed for PCSK9-EGF-A binding stem from the functional replacement of water occupying stable PCSK9 hydration sites (i.e., exchange of PCSK9 H-bonds from water to polar EGF-A groups).	Water	143-148	proprotein convertase subtilisin/kexin type 9	Homo sapiens	166-171
20589640-8	2010	We propose that the fast k(on) and entropically driven thermodynamics observed for PCSK9-EGF-A binding stem from the functional replacement of water occupying stable PCSK9 hydration sites (i.e., exchange of PCSK9 H-bonds from water to polar EGF-A groups).	Water	143-148	proprotein convertase subtilisin/kexin type 9	Homo sapiens	166-171
20589640-8	2010	We propose that the fast k(on) and entropically driven thermodynamics observed for PCSK9-EGF-A binding stem from the functional replacement of water occupying stable PCSK9 hydration sites (i.e., exchange of PCSK9 H-bonds from water to polar EGF-A groups).	Water	226-231	proprotein convertase subtilisin/kexin type 9	Homo sapiens	83-88
21038114-1	2010	BACKGROUND: Aquaporin-4 (AQP4) is the major water channel in the central nervous system.	Water	44-49	aquaporin 4	Rattus norvegicus	12-23
20815594-1	2010	We study the dynamics of hydration water/protein association in folded proteins using lysozyme and myoglobin as examples.	Water	35-40	myoglobin	Homo sapiens	99-108
20796278-13	2010	CONCLUSIONS: This exploratory study suggests that at a relatively high level of arsenic exposure, carriers of the short (GT)n allele (&lt; 27 repeats) in the HO-1 gene promoter had a lower probability of developing carotid atherosclerosis than non-carriers of the allele after long-term arsenic exposure via ground water.	Water	315-320	heme oxygenase 1	Homo sapiens	158-162
21103359-8	2010	Consistent with the increased accumulation of alpha-syn and alterations in mGluR5 in cognitive- and motor-associated brain regions, these mice displayed impaired performance in the water maze and pole test, these behavioral alterations were reversed with the mGluR5 antagonist, MPEP.	Water	181-186	synuclein, alpha	Mus musculus	46-55
30729606-9	2019	The growth and relative water content of wsd1 plants were compromised during drought, while leaf water loss of wsd1 was increased.	Water	24-29	O-acyltransferase (WSD1-like) family protein	Arabidopsis thaliana	41-45
26045628-12	2010	In gas phase, COb shifts towards Fed to compensate for the electron density donated to oxygen upon the elimination of H2O.	Water	118-121	metabolism of cobalamin associated B	Homo sapiens	14-17
20808797-4	2010	Transgenic mice overexpressing wild-type human alpha-synuclein drank water supplemented with NAC or control water supplemented with alanine from ages 6 weeks to 1 year.	Water	69-74	synuclein alpha	Homo sapiens	47-62
20630531-2	2010	Herein, we demonstrate a molecularly imprinted solid-phase extraction (MISPE) method for selective and reliable screening of trace BLAs in river and tap water.	Water	153-158	filamin B	Homo sapiens	149-152
30729606-9	2019	The growth and relative water content of wsd1 plants were compromised during drought, while leaf water loss of wsd1 was increased.	Water	97-102	O-acyltransferase (WSD1-like) family protein	Arabidopsis thaliana	111-115
20739606-1	2010	The mammalian aquaporins AQP1, AQP4, and AQP5 have been shown to function not only as water channels but also as gas channels.	Water	86-91	aquaporin 5	Homo sapiens	41-45
31179408-0	2019	Beyond Traditional Structure-Based Drug Design: The Role of Iron Complexation, Strain, and Water in the Binding of Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylase 2.	Water	91-96	egl-9 family hypoxia-inducible factor 1	Mus musculus	130-175
21058322-1	2010	The adsorption of water and substrate on immobilized Candida antarctica lipase B was studied by performing adsorption isotherm measurements and using inverse gas chromatography (IGC).	Water	18-23	PAN0_003d1715	Moesziomyces antarcticus	72-78
21058322-7	2010	As the conditions used for these adsorption studies resemble the ones of the continuous enzymatic solid/gas reactor, in which activity and selectivity of the lipase were extensively studied, it was possible to link adsorption results with particular effects of water on enzyme properties.	Water	261-266	PAN0_003d1715	Moesziomyces antarcticus	158-164
20684645-1	2010	We use 1D and 2D (2)H NMR to study the temperature-dependent mechanism for the rotational motion of myoglobin hydration water.	Water	120-125	myoglobin	Homo sapiens	100-109
31052777-2	2019	Here, we reported the two-photon absorption of a small squaraine dye (SD), and we found that the TPEF of the small SD can be enhanced significantly using albumin, the TPEF of SD in water was enhanced 17.7 times by adding bull serum albumin (BSA) in the solution.	Water	181-186	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	97-101
20609434-4	2010	In this article, we investigate the GTPase reaction of Ran in complex with its binding protein Ran-binding protein 1 by time-resolved Fourier transform infrared spectroscopy: We show that the slowdown of the intrinsic hydrolysis of RanGTP is accomplished by tyrosine 39, which is probably misplacing the attacking water.	Water	314-319	RAN, member RAS oncogene family	Homo sapiens	55-58
20609434-4	2010	In this article, we investigate the GTPase reaction of Ran in complex with its binding protein Ran-binding protein 1 by time-resolved Fourier transform infrared spectroscopy: We show that the slowdown of the intrinsic hydrolysis of RanGTP is accomplished by tyrosine 39, which is probably misplacing the attacking water.	Water	314-319	RAN binding protein 1	Homo sapiens	95-116
21117174-1	2010	Aquaporin-8 (AQP8) is a water channel expressed extensively in male and female reproductive systems.	Water	24-29	aquaporin 8	Mus musculus	0-11
21117174-1	2010	Aquaporin-8 (AQP8) is a water channel expressed extensively in male and female reproductive systems.	Water	24-29	aquaporin 8	Mus musculus	13-17
21117174-7	2010	Granulosa cells isolated from AQP8(-/-) mice showed 45% of decreased membrane water permeability than wild-type mice.	Water	78-83	aquaporin 8	Mus musculus	30-34
31052777-2	2019	Here, we reported the two-photon absorption of a small squaraine dye (SD), and we found that the TPEF of the small SD can be enhanced significantly using albumin, the TPEF of SD in water was enhanced 17.7 times by adding bull serum albumin (BSA) in the solution.	Water	181-186	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	167-171
21137980-9	2010	All together, it was concluded that the oxidized water-soluble multiwalled carbon nanotubes not only adsorb bovine serum albumin molecules to their surface, but also induces albumin molecules in the aqueous solution undergo secondary structure changes, which lead to a conformation change.	Water	49-54	albumin	Bos taurus	115-128
21137980-9	2010	All together, it was concluded that the oxidized water-soluble multiwalled carbon nanotubes not only adsorb bovine serum albumin molecules to their surface, but also induces albumin molecules in the aqueous solution undergo secondary structure changes, which lead to a conformation change.	Water	49-54	albumin	Bos taurus	121-128
20617833-0	2010	Formation of zein microphases in ethanol-water.	Water	41-46	zein	Zea mays	13-17
20617833-1	2010	Zein, a major protein of corn, is soluble in binary mixtures of ethanol and water.	Water	76-81	zein	Zea mays	0-4
20617833-5	2010	The objective of this work was to investigate the effect of zein concentration and the effect of ethanol-water ratio on the microphase behavior of zein solutions, believed to govern the morphology of microstructures after solvent evaporation.	Water	105-110	zein	Zea mays	147-151
20617833-7	2010	The study generated information on the zein concentration-ethanol/water ratio conditions where microspheres are formed and provided insight into the microphase behavior of zein ethanolic solutions.	Water	66-71	zein	Zea mays	39-43
30958488-4	2019	By spin-coating a synthetic gold-modified MoS2 hybrid photoanode on a FTO substrate, the efficiency of photoelectrochemical water oxidation was significantly enhanced, by 2 times (nanorods) and 3.5 times (nanoparticles) in the visible-infrared region; furthermore, the average optical resistance was reduced by a factor of two compared to the MoS2 photoanode without Au, and the photocurrent increases exponentially when the system bias was greater than 0.7 volts.	Water	124-129	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	70-73
20363621-6	2010	At water content of 0.42%, the initial reaction rate and FAME yield displayed optimum values of 3.317 g/L min and 98%, respectively.	Water	3-8	benign adult familial myoclonic epilepsy 1	Homo sapiens	57-61
30933517-5	2019	Herein, we have contributed to this goal by performing explicit-solvent, microsecond-long Replica Exchange with Solute Scaling (REST2) simulations of alpha-synuclein with the coarse-grained force field SIRAH, finding that a 30% increase in the default strength of protein-water interactions yields a much better reproduction of its radius of gyration.	Water	272-277	synuclein alpha	Homo sapiens	150-165
20447810-3	2010	The t-BA/water cosolvent SLN dispersion was subsequently lyophilized to obtain a dry product which, upon rehydration, formed an aqueous dispersion of spherical SLNs with a size under 200 nm.	Water	9-14	sarcolipin	Homo sapiens	25-28
20819947-0	2010	Cotransport of water by the Na+-K+-2Cl(-) cotransporter NKCC1 in mammalian epithelial cells.	Water	15-20	solute carrier family 12 member 2	Homo sapiens	56-61
20819947-1	2010	Water transport by the Na+-K+-2Cl(-) cotransporter (NKCC1) was studied in confluent cultures of pigmented epithelial (PE) cells from the ciliary body of the fetal human eye.	Water	0-5	solute carrier family 12 member 2	Homo sapiens	52-57
20819947-2	2010	Interdependence among water, Na+ and Cl(-) fluxes mediated by NKCC1 was inferred from changes in cell water volume, monitored by intracellular self-quenching of the fluorescent dye calcein.	Water	22-27	solute carrier family 12 member 2	Homo sapiens	62-67
30908047-10	2019	However, when water-water interactions compete with water-amino acid interactions in the larger clusters, DFT results show greater disagreement with experiment when compared to MP2 results.	Water	14-19	tryptase pseudogene 1	Homo sapiens	177-180
20819947-2	2010	Interdependence among water, Na+ and Cl(-) fluxes mediated by NKCC1 was inferred from changes in cell water volume, monitored by intracellular self-quenching of the fluorescent dye calcein.	Water	102-107	solute carrier family 12 member 2	Homo sapiens	62-67
20819947-8	2010	Our findings support a previous investigation, in which we showed water transport by NKCC1 to be a result of a balance between ionic and osmotic gradients.	Water	66-71	solute carrier family 12 member 2	Homo sapiens	85-90
20819947-9	2010	The coupling between salt and water transport in NKCC1 represents a novel aspect of cellular water homeostasis where cells can change their volume independently of the direction of an osmotic gradient across the membrane.	Water	30-35	solute carrier family 12 member 2	Homo sapiens	49-54
20819947-9	2010	The coupling between salt and water transport in NKCC1 represents a novel aspect of cellular water homeostasis where cells can change their volume independently of the direction of an osmotic gradient across the membrane.	Water	93-98	solute carrier family 12 member 2	Homo sapiens	49-54
20533894-7	2010	TAKE HOME MESSAGE: The NK1 receptor research has led to the clinical introduction of aprepitant in 2003 and its water soluble injectable form, fosaprepitant dimeglumine, in 2009 by Merck for the prevention of postoperative nausea and vomiting and for inhibiting chemotherapy-induced nausea and vomiting.	Water	112-117	tachykinin receptor 1	Homo sapiens	23-35
30908047-10	2019	However, when water-water interactions compete with water-amino acid interactions in the larger clusters, DFT results show greater disagreement with experiment when compared to MP2 results.	Water	20-25	tryptase pseudogene 1	Homo sapiens	177-180
30908047-10	2019	However, when water-water interactions compete with water-amino acid interactions in the larger clusters, DFT results show greater disagreement with experiment when compared to MP2 results.	Water	20-25	tryptase pseudogene 1	Homo sapiens	177-180
20198690-7	2010	Surface characterization of EGF-SAMs was performed using radiolabeling, water contact angle measurements, X-ray photoelectron spectroscopy, and ELISA.	Water	72-77	epidermal growth factor	Homo sapiens	28-31
30682647-2	2019	The HQ-BT showed a weak fluorescence that could be strongly enhanced by coordination with various metal ions such as Al3+, Cd2+, Zn2+ in methanol containing 1% water.	Water	160-165	CD2 molecule	Homo sapiens	123-126
20732719-9	2010	Single-walled nanotubes and multi-walled nanotubes that were differentially functionalized to be water-soluble, varied in their effects; specifically the concentrations at which they were stimulatory and they were more stimulatory to IL-1beta expression compared with unfunctionalized nanotubes.	Water	97-102	interleukin-1 beta	Oncorhynchus mykiss	234-242
20237060-0	2010	Protein-enriched diet increases water absorption via the aquaporin-2 water channels in healthy humans.	Water	32-37	aquaporin 2	Homo sapiens	57-68
20853826-7	2010	For the GSTP1-1 enzyme, we have demonstrated that a water molecule, after an initial conformational rearrangement of GSH, can assist a proton transfer between the GSH cysteine thiol (GSH-SH) and the GSH glutamate alpha carboxylate (GSH-COO(-)) groups.	Water	52-57	glutathione S-transferase pi 1	Homo sapiens	8-15
30659792-3	2019	This research is focused on two of the remaining questions: How permeable is AQP3 to water?	Water	85-90	aquaporin 3 (Gill blood group)	Homo sapiens	77-81
20639513-1	2010	Expression of aquaporin-1 (AQP1) and -2 (AQP2) channels in the kidney are critical for the maintenance of water homeostasis and the operation of the urinary concentrating mechanism.	Water	106-111	aquaporin 2	Mus musculus	41-45
20237060-0	2010	Protein-enriched diet increases water absorption via the aquaporin-2 water channels in healthy humans.	Water	69-74	aquaporin 2	Homo sapiens	57-68
20237060-9	2010	CONCLUSIONS: The protein-enriched diet increased water absorption via an increased transport via the aquaporin-2 water channels.	Water	49-54	aquaporin 2	Homo sapiens	101-112
20237060-9	2010	CONCLUSIONS: The protein-enriched diet increased water absorption via an increased transport via the aquaporin-2 water channels.	Water	113-118	aquaporin 2	Homo sapiens	101-112
21152274-1	2010	Complexes (H(2)O/CO(2), e-(H(2)O/CO(2)) and h(+)-(H(2)O/CO(2))) in the reaction system of CO(2) photoreduction with H(2)O were researched by B3LYP and MP2 methods along with natural bond orbital (NBO) analysis.	Water	11-16	tryptase pseudogene 1	Homo sapiens	151-154
21152274-1	2010	Complexes (H(2)O/CO(2), e-(H(2)O/CO(2)) and h(+)-(H(2)O/CO(2))) in the reaction system of CO(2) photoreduction with H(2)O were researched by B3LYP and MP2 methods along with natural bond orbital (NBO) analysis.	Water	27-32	tryptase pseudogene 1	Homo sapiens	151-154
30659792-5	2019	Through atomistic modelling and large-scale simulations, we found that AQP3 is two to three times more permeable to water than AQP1 and that the glycerol-AQP3 affinity is approximately 500/M.	Water	116-121	aquaporin 3 (Gill blood group)	Homo sapiens	71-75
21152274-1	2010	Complexes (H(2)O/CO(2), e-(H(2)O/CO(2)) and h(+)-(H(2)O/CO(2))) in the reaction system of CO(2) photoreduction with H(2)O were researched by B3LYP and MP2 methods along with natural bond orbital (NBO) analysis.	Water	27-32	tryptase pseudogene 1	Homo sapiens	151-154
21152274-1	2010	Complexes (H(2)O/CO(2), e-(H(2)O/CO(2)) and h(+)-(H(2)O/CO(2))) in the reaction system of CO(2) photoreduction with H(2)O were researched by B3LYP and MP2 methods along with natural bond orbital (NBO) analysis.	Water	27-32	tryptase pseudogene 1	Homo sapiens	151-154
30659792-9	2019	We observed close agreement between the experimentally measured and the computationally predicted time courses of erythrocytes, which corroborated our computational conclusions on the AQP3 water-permeability and the glycerol-AQP3 affinity.	Water	189-194	aquaporin 3 (Gill blood group)	Homo sapiens	184-188
30702925-2	2019	Previously, our lab showed in vitro heteromer formation between angiotensin II receptor type 1 subtype a (AT1aR) and secretin receptor (SCTR), which is involved in in vivo control of hyperosmolality-induced water drinking behavior.	Water	207-212	secretin receptor	Homo sapiens	117-134
20578774-6	2010	Overall spectral assignment was supported by ab initio calculations at the MP2 level on small water clusters.	Water	94-99	tryptase pseudogene 1	Homo sapiens	75-78
20675860-0	2010	SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.	Water	56-61	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
20688918-6	2010	We sought to identify a Ca(2+)-regulated pathway that could trigger Pyk2 phosphorylation in T cells and found that ionomycin stimulated the production of reactive oxygen species and an H(2)O(2) scavenger inhibited ionomycin-induced Pyk2 phosphorylation.	Water	185-190	protein tyrosine kinase 2 beta	Homo sapiens	232-236
30702925-2	2019	Previously, our lab showed in vitro heteromer formation between angiotensin II receptor type 1 subtype a (AT1aR) and secretin receptor (SCTR), which is involved in in vivo control of hyperosmolality-induced water drinking behavior.	Water	207-212	secretin receptor	Homo sapiens	136-140
20632760-0	2010	Enhancement of the water proton relaxivity by trapping Gd3+ complexes in nanovesicles.	Water	19-24	GRDX	Homo sapiens	55-58
30676864-0	2019	Modulation of cardiac vascular endothelial growth factor and PGC-1alpha with regular postexercise cold-water immersion of rats.	Water	103-108	vascular endothelial growth factor A	Rattus norvegicus	22-56
20637417-0	2010	An active site water network in the plasminogen activator pla from Yersinia pestis.	Water	15-20	plasminogen activator protease precursor	Yersinia pestis	36-39
20817247-13	2010	The PIPP score was significantly lower in infants given sucrose than in those given sterile water (mean 5 8, 95% CI 3 7-7 8 vs 8 5, 7 3-9 8; p=0 02) and significantly more infants had no change in facial expression after sucrose administration (seven of 20 [35%] vs none of 24; p&lt;0 0001).	Water	92-97	inositol polyphosphate-5-phosphatase J	Homo sapiens	4-8
30676864-14	2019	NEW &amp; NOTEWORTHY A regular postexercise cold-water immersion for 10 wk of endurance training augmented the myocardial mitochondrial biogenesis and vascular angiogenesis coactivators peroxisome proliferator-activated receptor gamma coactivator-1alpha and vascular endothelial growth factor, respectively.	Water	49-54	vascular endothelial growth factor A	Rattus norvegicus	258-292
20683516-5	2010	High temperature evacuation of HY zeolite [1] formed very strong LAS, a part of which was irreversible to BAS by water re-adsorption at room temperature.	Water	113-118	lipoic acid synthetase	Homo sapiens	65-68
20683516-8	2010	Thus, LAS on HY zeolite [3] seemed irreversible by pyridine adsorption after water re-adsorption.	Water	77-82	lipoic acid synthetase	Homo sapiens	6-9
20558542-7	2010	Inhibition of c-Src activity and silencing c-Src expression abrogated the light chain-induced MCP-1 response, but had no effect on H(2)O(2), indicating that production of H(2)O(2) is upstream of c-Src in the signaling cascade.	Water	171-176	C-C motif chemokine ligand 2	Homo sapiens	94-99
30678949-4	2019	Fe3O4/SiO2-Pr-S-Ag NPs show high catalytic activity as recyclable nanocatalyst toward degradation of 4-nitrophenol (4-NP), rhodamine B (RhB), and Methylene blue (MB) in the presence of NaBH4 in water at room temperature.	Water	194-199	S-antigen visual arrestin	Homo sapiens	14-18
30907858-2	2019	This report demonstrates that ICE membranes are detectable by anterior segment optical coherence tomography (AS-OCT) and highlights the benefits of using AS-OCT in ICE syndrome.	Water	30-33	plexin A2	Homo sapiens	112-115
20452263-0	2010	Investigation of the dynamical properties of water in elastin by deuterium Double Quantum Filtered NMR.	Water	45-50	elastin	Bos taurus	54-61
20836560-7	2010	Moreover, another unique responsiveness is discovered for the film state: that is, the film color is varied when it is exposed to the vapor of water or methanol (vaporchromism), resulting from the structural change of PT1 occurring even in the film state.	Water	143-148	zinc finger protein 77	Homo sapiens	218-221
30907858-2	2019	This report demonstrates that ICE membranes are detectable by anterior segment optical coherence tomography (AS-OCT) and highlights the benefits of using AS-OCT in ICE syndrome.	Water	30-33	plexin A2	Homo sapiens	157-160
30907858-12	2019	Chronicling ICE membranes longitudinally with AS-OCT will enhance understanding of disease progression.	Water	12-15	plexin A2	Homo sapiens	49-52
21280568-4	2010	This reaffirmed that the product of reduction of O2 by plant AOX was H2O2 as found earlier and not H2O as reported in some recent reviews.	Water	69-72	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	61-64
20219947-10	2010	CLN3p-deficient mice with free access to water showed a mild urine-concentrating defect but, upon water deprivation, were able to concentrate their urine normally.	Water	41-46	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	0-5
20219947-10	2010	CLN3p-deficient mice with free access to water showed a mild urine-concentrating defect but, upon water deprivation, were able to concentrate their urine normally.	Water	98-103	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	0-5
31033226-9	2019	Yet, water restriction only elevated urinary osmolality by 28% in these mice as opposed to 104% in non-SCD mice despite similar degree increases of protein abundance of AQP2, NKCC2 and AQP2-S256-P. Water-restriction had no significant effect on protein abundance of ENaC or AQP1 in either strain.	Water	5-10	aquaporin 2	Mus musculus	169-173
20219947-12	2010	Together, these findings suggest an osmoregulated role for CLN3p in renal control of water and K(+) balance.	Water	85-90	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	59-64
21468191-1	2010	When the concentration of sodium (Na(+)) in arterial plasma (P(Na)) declines sufficiently to inhibit the release of vasopressin, water will be excreted promptly when the vast majority of aquaporin 2 water channels (AQP2) have been removed from luminal membranes of late distal nephron segments.	Water	129-134	aquaporin 2	Rattus norvegicus	187-198
21468191-1	2010	When the concentration of sodium (Na(+)) in arterial plasma (P(Na)) declines sufficiently to inhibit the release of vasopressin, water will be excreted promptly when the vast majority of aquaporin 2 water channels (AQP2) have been removed from luminal membranes of late distal nephron segments.	Water	129-134	aquaporin 2	Rattus norvegicus	215-219
31033226-9	2019	Yet, water restriction only elevated urinary osmolality by 28% in these mice as opposed to 104% in non-SCD mice despite similar degree increases of protein abundance of AQP2, NKCC2 and AQP2-S256-P. Water-restriction had no significant effect on protein abundance of ENaC or AQP1 in either strain.	Water	5-10	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	266-270
20107166-9	2010	CONCLUSIONS: These results suggest that signaling of TLR2, TRL3, TRL4, and TRL9 is highly redundant in the adjuvant effect needed to induce EAU and that diverse microbial infections may contribute to the pathogenesis of diseases such as uveitis.	Water	140-143	tuberculosis resistance 3	Mus musculus	59-63
31108641-4	2019	Measurements of T_{1} proton relaxation on water saturating microcapillary tubes are performed to reveal the effect.	Water	43-48	CD5 molecule	Homo sapiens	16-20
31031570-0	2019	The Role of Mineral Sea Water Bonding Process with Graphite-Aluminum Electrodes as Electric Generator.	Water	24-29	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	20-23
20169476-7	2010	RESULTS: The reconstructed attenuation coefficient of water at 140 keV was .150 +/- .003/cm in the uniform region of the ACR phantom, .151 +/- .003/cm and .151 +/- .002/cm in the liver and cardiac regions of the anthropomorphic phantom.	Water	54-59	acrosin	Homo sapiens	121-124
31031570-5	2019	The result shows that each electrode produces different voltage when interacting with sea water.	Water	90-95	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	86-89
20091827-0	2010	Investigation of PEG crystallization in frozen PEG-sucrose-water solutions.	Water	59-64	progestagen associated endometrial protein	Homo sapiens	17-20
31031570-6	2019	It is caused by the patterns of the electron movement disrupted by the electron of sea water in producing a new compound.	Water	87-92	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	83-86
31031570-9	2019	This research elucidates the role of sea water elements in boosting kinetic energy of delocalized electron on graphite resulting in an electron jump.	Water	41-46	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	7-10
30673164-0	2019	Controlled Synthesis of Surfactant-Free Water-Dispersible Colloidal Platinum Nanoparticles by the Co4Cat Process.	Water	40-45	complement C4A (Rodgers blood group)	Homo sapiens	98-101
20334402-11	2010	Microscale phase separation occurs on annealing 1 wt % PU-1 for 24 h at 60 degrees C. Surprisingly, phase separation was also observed after short immersion of 1 wt % PU-1 coatings in water.	Water	184-189	Spi-1 proto-oncogene	Homo sapiens	55-59
20334402-11	2010	Microscale phase separation occurs on annealing 1 wt % PU-1 for 24 h at 60 degrees C. Surprisingly, phase separation was also observed after short immersion of 1 wt % PU-1 coatings in water.	Water	184-189	Spi-1 proto-oncogene	Homo sapiens	167-171
30843559-2	2019	In this work, we described a novel binary solution (DETA/H2O) reaction for preparing a composite catalyst composed of CdS nanoparticles grown on CoSe2 nanobelts.	Water	57-60	CDP-diacylglycerol synthase 1	Homo sapiens	118-121
20214940-0	2010	Centrally administered relaxin-3 induces Fos expression in the osmosensitive areas in rat brain and facilitates water intake.	Water	112-117	relaxin 3	Rattus norvegicus	23-32
30890708-1	2019	Changes in sea level may be attributed either to barotropic (involving the entire water column) or baroclinic processes (governed by stratification).	Water	82-87	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	11-14
20214940-9	2010	Further, icv administered relaxin-3 (180 pmol/rat) significantly increased water intake, and the effect was as strong as that of relaxin-2 (180 pmol/rat).	Water	75-80	relaxin 3	Rattus norvegicus	26-35
20353182-12	2010	When they are spread at an air/water interface, the limiting area and the collapse pressures are 16.6 A(2)/amino acid and 31 mN/m for B6.4-13 and 17.8 A(2)/amino acid and 35 mN/m for B13-17, respectively.	Water	31-36	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	183-186
30862702-3	2019	Here, we investigated the proposed water-mediated, hydrogen-bonded activation switch between the conserved NPxxY motif on transmembrane helix 7 (TMH7) and a conserved tyrosine in TMH5, which contributes to alpha1B-adrenoceptor (alpha1B-AR) and beta2-AR activation.	Water	35-40	adenosine A2a receptor	Homo sapiens	244-252
20364123-3	2010	Here we identify a member of the degenerin/epithelial sodium channel family, PPK28, as an osmosensitive ion channel that mediates the cellular and behavioural response to water.	Water	171-176	pickpocket 28	Drosophila melanogaster	77-82
20364123-4	2010	We use molecular, cellular, calcium imaging and electrophysiological approaches to show that ppk28 is expressed in water-sensing neurons, and that loss of ppk28 abolishes water sensitivity.	Water	115-120	pickpocket 28	Drosophila melanogaster	93-98
20364123-4	2010	We use molecular, cellular, calcium imaging and electrophysiological approaches to show that ppk28 is expressed in water-sensing neurons, and that loss of ppk28 abolishes water sensitivity.	Water	171-176	pickpocket 28	Drosophila melanogaster	155-160
20364123-5	2010	Moreover, ectopic expression of ppk28 confers water sensitivity to bitter-sensing gustatory neurons in the fly and sensitivity to hypo-osmotic solutions when expressed in heterologous cells.	Water	46-51	pickpocket 28	Drosophila melanogaster	32-37
30850706-9	2019	These findings suggest that tap water in high income countries could serve as an important source of community exposure to ESBL and carbapenemase genes, and that these genes may be disseminated by non-Enterobacteriaceae that are not detected as part of standard microbiological water quality testing.	Water	32-37	carbapenemase	Escherichia coli	132-145
20385653-5	2010	We show that after a chronic 8 week treatment, benfotiamine dose-dependently enhanced the spatial memory of amyloid precursor protein/presenilin-1 mice in the Morris water maze test.	Water	166-171	amyloid beta (A4) precursor protein	Mus musculus	108-133
30854427-4	2019	Our results document that initial sea ice reductions at the core site preceded the major reinvigoration of convective deep-water formation in the Nordic Seas and abrupt Greenland warming; sea ice expansions preceded the buildup of a deep oceanic heat reservoir.	Water	123-128	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	34-37
20222012-7	2010	Furthermore, steady-state kinetic analysis of a variety of Scp1 mutants revealed the importance of Asp206 in Mg(2+) coordination mediated by a water molecule.	Water	143-148	CTD small phosphatase 1	Homo sapiens	59-63
30623723-1	2019	The inner medullary collecting duct (IMCD) produces very high levels of endothelin-1 (ET-1) that acts as an autocrine inhibitor of IMCD Na+ and water reabsorption.	Water	144-149	endothelin 1	Mus musculus	72-84
20227748-0	2010	Atmospheric transport of water-soluble ions (NO3(-), NH4(+) and nss-SO4(2-)) to the southern East Sea (Sea of Japan).	Water	25-30	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	98-101
20227748-0	2010	Atmospheric transport of water-soluble ions (NO3(-), NH4(+) and nss-SO4(2-)) to the southern East Sea (Sea of Japan).	Water	25-30	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	103-106
20147612-3	2010	In contrast, NO produced by renal NOS 3 promotes water excretion by reducing renal vascular resistance, increasing glomerular filtration, and inhibiting reabsorption along the nephron.	Water	49-54	nitric oxide synthase 3, endothelial cell	Mus musculus	34-39
20147612-5	2010	We hypothesized that NO produced by NOS 3 promotes water excretion primarily due to renal tubular effects.	Water	51-56	nitric oxide synthase 3, endothelial cell	Mus musculus	36-41
30623723-1	2019	The inner medullary collecting duct (IMCD) produces very high levels of endothelin-1 (ET-1) that acts as an autocrine inhibitor of IMCD Na+ and water reabsorption.	Water	144-149	endothelin 1	Mus musculus	86-90
20147612-14	2010	We conclude that 1) NO produced by NOS 3 promotes water and Na(+) excretion and 2) the renal epithelial actions of NO produced by NOS 3 supersede the systemic and renal vascular actions.	Water	50-55	nitric oxide synthase 3, endothelial cell	Mus musculus	35-40
30364970-3	2019	Among the compounds investigated, choline chloride-oxalic acid-water of DESs-H2O with various molar ratios with 1:0.1-1:50 showed the greatest change in viscosity with 3617-2 mPa s, and effectively extracted most of the target compounds of polyphenols (52.1 mug mL-1 for protocatechuic acid, 7.3 mug mL-1 for catechins, 34.0 mug mL-1 for epicatechin and 6.2 mug mL-1 for caffeic acid) from samples.	Water	63-68	L1 cell adhesion molecule	Mus musculus	262-266
20379888-3	2010	Based on functional data indicating their possible involvement in water holding capacity and their expression in skeletal muscle, we selected five positional candidates (ACO2, ADSL, CBY1, KCNJ4, PLA2AG6) out of 130 predicted genes in the QTL interval for further analysis.	Water	66-71	protein chibby homolog 1	Sus scrofa	182-186
19495975-2	2010	AQP2 is expressed in the collection duct of the kidney, serving as the final channel that helps to regulate water excretion in the kidneys and affecting the regulation of water and hyponatremia in cirrhotic patients.	Water	108-113	aquaporin 2	Homo sapiens	0-4
19495975-2	2010	AQP2 is expressed in the collection duct of the kidney, serving as the final channel that helps to regulate water excretion in the kidneys and affecting the regulation of water and hyponatremia in cirrhotic patients.	Water	171-176	aquaporin 2	Homo sapiens	0-4
20305644-3	2010	Here, we report a process for converting sea water (salinity approximately 500 mM or approximately 30,000 mg l(-1)) to fresh water (salinity &lt;10 mM or &lt;600 mg l(-1)) in which a continuous stream of sea water is divided into desalted and concentrated streams by ion concentration polarization, a phenomenon that occurs when an ion current is passed through ion-selective membranes.	Water	125-130	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	204-207
19322880-6	2010	HA coating enhanced the cell proliferation, the ALP activity, and the levels of osteocalcin on both low and high water-content PVA-Hs.	Water	113-118	bone gamma-carboxyglutamate protein 2	Mus musculus	80-91
20044151-6	2010	As well, mRNAs of the genes for H+ATPase and Na+/H+ exchanger (NHE2), associated with NH3 excretion, were also upregulated by 7.2- and 13-fold, respectively, in embryos exposed to alkaline water relative to controls.	Water	189-194	sodium/hydrogen exchanger 2	Oncorhynchus mykiss	63-67
19796672-10	2010	Furthermore, such a distribution of AQP-2, -3, and V2-R suggests that VP-AQP-2 mediated water transport might work actively in the basal cells from perilymph towards endolymph containing AQP-1, -7 and -9.	Water	88-93	aquaporin 2	Homo sapiens	36-41
19796672-10	2010	Furthermore, such a distribution of AQP-2, -3, and V2-R suggests that VP-AQP-2 mediated water transport might work actively in the basal cells from perilymph towards endolymph containing AQP-1, -7 and -9.	Water	88-93	aquaporin 2	Homo sapiens	73-78
19892445-1	2010	Isotopes of uranium in the sea-water sediments collected from two different areas (El Hamraween harbour and Ras El Behar) on the Egyptian coast of the red sea have been studied using radiochemical separation procedures and alpha-particle spectrometry.	Water	31-36	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	27-30
19892445-3	2010	The activities observed indicated enhanced radioactivity levels in sea-water sediments of El Hamraween harbour area due to the activities of phosphate shipment operation.	Water	71-76	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	67-70
19834786-4	2010	It was observed that, after mixing the toothpastes with water and saliva in order to reproduce in vivo conditions, a crystallization of nano-CHA takes place.	Water	56-61	transcription factor like 5	Homo sapiens	141-144
20020754-6	2010	The (PLA/HSA)(3) nanotubes swelled considerably in water, although the outer diameter was almost unaltered.	Water	51-56	olfactory receptor family 6 subfamily C member 2	Homo sapiens	5-15
19933270-4	2010	Exposure of neutrophils or HEK 293 cells to H(2)O(2) was associated with reduced binding between phosphorylated I kappaB alpha and SCF(beta-TrCP) but no change in the composition of the SCF(beta-TrCP) complex.	Water	44-50	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	135-144
19933270-4	2010	Exposure of neutrophils or HEK 293 cells to H(2)O(2) was associated with reduced binding between phosphorylated I kappaB alpha and SCF(beta-TrCP) but no change in the composition of the SCF(beta-TrCP) complex.	Water	44-50	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	190-199
20078163-1	2010	A distributed point polarizable model (DPP2) for water, with explicit terms for charge penetration, induction, and charge transfer, is introduced.	Water	49-54	dipeptidyl peptidase 7	Homo sapiens	39-43
20078163-2	2010	The DPP2 model accurately describes the interaction energies in small and large water clusters and also gives an average internal energy per molecule and radial distribution functions of liquid water in good agreement with experiment.	Water	80-85	dipeptidyl peptidase 7	Homo sapiens	4-8
20078163-2	2010	The DPP2 model accurately describes the interaction energies in small and large water clusters and also gives an average internal energy per molecule and radial distribution functions of liquid water in good agreement with experiment.	Water	194-199	dipeptidyl peptidase 7	Homo sapiens	4-8
20078167-9	2010	The average magnitude of the dipole moment of the water molecules in the first shell treated at the MP2-level, with the more distant waters handled with an AMOEBA effective charge model, is 2.67 D. This value is close to the AMOEBA result for first-shell waters (2.72 D) and is slightly reduced from the bulk AMOEBA value (2.78 D).	Water	50-55	tryptase pseudogene 1	Homo sapiens	100-103
21918624-7	2010	Molecular dynamics simulations of Crh confirmed the tendencies observed in NMR conformers, as a paradoxical increase of the distance between the two beta1a strands, when the structure gets closer to the crystallographic structure, and the role of water bridges in this context.	Water	247-252	corticotropin releasing hormone	Homo sapiens	34-37
20724536-1	2010	Arginine-vasopressin (AVP) modulates the water channel aquaporin-2 (AQP2) in the renal collecting duct to maintain homeostasis of body water.	Water	41-46	aquaporin 2	Homo sapiens	68-72
20935394-7	2010	RESULTS: Overall bacterial growth was 58% (29 out of 50 blades) after tap-water cleaning (of which 60% were pathogenic organisms) versus 3.4% (one out of 29 blades) after tap-water cleaning followed by immersion in disinfectant (all of which were commensals).	Water	74-79	filamin B	Homo sapiens	70-73
20935394-7	2010	RESULTS: Overall bacterial growth was 58% (29 out of 50 blades) after tap-water cleaning (of which 60% were pathogenic organisms) versus 3.4% (one out of 29 blades) after tap-water cleaning followed by immersion in disinfectant (all of which were commensals).	Water	175-180	filamin B	Homo sapiens	171-174
20935394-11	2010	Washing with tap-water followed by disinfection with 5% v/v aldehyde-free biguanide for at least 10 min is an effective and inexpensive alternative.	Water	17-22	filamin B	Homo sapiens	13-16
20663063-5	2010	Under high salinity, the endogenous contents of H(2) O(2) were elevated in wild-type and sid2 seeds but reduced to original concentrations after treatment with 1 muM SA.	Water	48-54	ADC synthase superfamily protein	Arabidopsis thaliana	89-93
20619437-4	2010	The rejection efficiency of finished water from the Yangshupu drinking water treatment plant (YDWTP) is 12%, 31%, 8% of nitrate, 26%, 28%, 23% of ammonia, 77%, 78%, 82% of DOC (dissolved organic carbon), and 83%, 87% 88% of UV(254) for HL, NF90 and NF270, respectively.	Water	37-42	interleukin enhancer binding factor 3	Homo sapiens	240-244
20714568-1	2010	Alpha-synuclein, a natively unstructured protein important in the neuropathology of Parkinson"s disease, was found to form a Langmuir monolayer in an alpha-helical conformation with its helical axis parallel to the air-water interface.	Water	219-224	synuclein alpha	Homo sapiens	0-15
20722444-1	2010	Electron capture dynamics of the water tetramer (H(2)O)(n) (n = 4) have been investigated by means of a full-dimensional direct ab initio molecular dynamics (MD) method at the MP2/6-311++G(d,p) level.	Water	33-38	tryptase pseudogene 1	Homo sapiens	176-179
20121341-3	2010	Simulations reproduced experimental observations of the rapid and transient oxidation of glutathione and the rapid, sustained oxidation of thioredoxin on exposure to extracellular H(2)O(2).	Water	180-185	thioredoxin	Homo sapiens	139-150
20844118-9	2010	These results demonstrate that HsTRPA, originally arisen by the duplication of Water witch, has acquired thermal- and chemical-responsive properties, which has resulted in the loss of ancient TRPA1.	Water	79-84	HsTRPA	Apis mellifera	31-37
20707348-6	2010	The prospects of using the PFP-functionalized surface to modify its properties (e.g., the interaction with solvents, especially water) and design new types of the heterogeneous catalytic system are discussed.	Water	128-133	perforin 1	Homo sapiens	27-30
20652203-8	2010	A columnar crystal structure is inherent for PdL(1).3H(2)O with the water molecules present as discrete (H(2)O)(3) clusters.	Water	68-73	CD274 molecule	Homo sapiens	45-50
20338153-8	2010	MALDI-TOF mass spectrometry of phosphylated human butyrylcholinesterase (hBChE) in water and in (18)O-water provided evidence that aging results from O-C breakage, i.e. O-dealkylation.	Water	83-88	butyrylcholinesterase	Homo sapiens	73-78
20669931-1	2010	Based on a large database of local minima obtained with the polarizable AMOEBA potential, the generalized energy-based fragmentation (GEBF) approach is applied to locate low-lying structures of water clusters (H(2)O)(n) in the range n = 20-30, at the B3LYP and MP2 levels.	Water	194-199	tryptase pseudogene 1	Homo sapiens	261-264
21567558-2	2010	In solution, this side-chain copolymer adopts a globular architecture and about five molecules of the water-insoluble chromophore PDI were successfully incorporated into these micelles for receptor-mediated cell uptake investigations.	Water	102-107	peptidyl arginine deiminase 1	Homo sapiens	130-133
21038114-1	2010	BACKGROUND: Aquaporin-4 (AQP4) is the major water channel in the central nervous system.	Water	44-49	aquaporin 4	Rattus norvegicus	25-29
20823673-4	2010	Organothiophosphorus pesticides (P=S type) are easily oxidized to their phosphorus compounds (P=O type) in chlorinated water containing HOCl as little as 0.5 mg/l, resulting in an increase in cholinesterase-inhibitory activity.	Water	119-124	butyrylcholinesterase	Homo sapiens	192-206
20433905-6	2010	We found that deleting Nogo ameliorates learning and memory deficits of APP transgenic mice in the Morris water maze at an early/intermediate stage of the disease.	Water	106-111	reticulon 4	Mus musculus	23-27
20388493-4	2010	Here we find four small grottos connecting with the vestibule of the NaK selectivity filter, which form a vestibule-grotto complex perpendicular to the filter pore with a few water molecules within it.	Water	175-180	TANK binding kinase 1	Homo sapiens	69-72
21090295-1	2010	The course of intermittent sediment disturbance-sedimentation, that sediment disturbance was for 10 min and succeeding sedimentation was for 1430 min each day over a 17-day period, was simulated to investigate the variation of bioavailable phosphorus (BAP) in overlying water.	Water	270-275	prohibitin 2	Homo sapiens	252-255
19747527-0	2010	The subcellular distribution of aquaporin 5 in the cochlea reveals a water shunt at the perilymph-endolymph barrier.	Water	69-74	aquaporin 5	Homo sapiens	32-43
19747527-13	2010	This differential localization of AQP5 and AQP4 in the apical and basolateral membranes of the same epithelial cell type suggests a direct aquaporin-mediated transcellular water shunt between the perilymph and endolymph in the OSCs of the cochlear lateral wall.	Water	172-177	aquaporin 5	Homo sapiens	34-38
19962432-1	2010	The water channel aquaporin 4 (AQP4) is abundantly expressed in astrocytes and provides a mechanism by which water permeability of the plasma membrane can be regulated.	Water	4-9	aquaporin 4	Rattus norvegicus	31-35
20109536-6	2010	Our transcriptional profiling of injured rat cords suggests that elevated AQP4-mediated water influx accompanies increased uptake of chloride and potassium ions which represents a protective astrocytic reaction to hypoxia.	Water	88-93	aquaporin 4	Rattus norvegicus	74-78
20411194-3	2010	Using QM MP2/aug-cc-pVDZ the calculated average interaction energy reveals that the hydrogen-bonded acetone-water complex is energetically more stable under supercritical conditions than ambient conditions and its stability is little affected by variations of temperature and/or pressure.	Water	108-113	tryptase pseudogene 1	Homo sapiens	9-12
20825031-2	2010	The performance of the MFC-type biotoxicity detector was evaluated with the synthetic water containing heavy metals of Cd2+ and Cu2+.	Water	86-91	CD2 molecule	Homo sapiens	119-122
30364970-3	2019	Among the compounds investigated, choline chloride-oxalic acid-water of DESs-H2O with various molar ratios with 1:0.1-1:50 showed the greatest change in viscosity with 3617-2 mPa s, and effectively extracted most of the target compounds of polyphenols (52.1 mug mL-1 for protocatechuic acid, 7.3 mug mL-1 for catechins, 34.0 mug mL-1 for epicatechin and 6.2 mug mL-1 for caffeic acid) from samples.	Water	63-68	L1 cell adhesion molecule	Mus musculus	300-304
30364970-3	2019	Among the compounds investigated, choline chloride-oxalic acid-water of DESs-H2O with various molar ratios with 1:0.1-1:50 showed the greatest change in viscosity with 3617-2 mPa s, and effectively extracted most of the target compounds of polyphenols (52.1 mug mL-1 for protocatechuic acid, 7.3 mug mL-1 for catechins, 34.0 mug mL-1 for epicatechin and 6.2 mug mL-1 for caffeic acid) from samples.	Water	63-68	L1 cell adhesion molecule	Mus musculus	300-304
20382397-12	2010	The fundamental findings obtained in this research are especially valuable for the development of sensitive and reliable SERS methods for rapid analysis of arsenic in contaminated water.	Water	180-185	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	121-125
30364970-3	2019	Among the compounds investigated, choline chloride-oxalic acid-water of DESs-H2O with various molar ratios with 1:0.1-1:50 showed the greatest change in viscosity with 3617-2 mPa s, and effectively extracted most of the target compounds of polyphenols (52.1 mug mL-1 for protocatechuic acid, 7.3 mug mL-1 for catechins, 34.0 mug mL-1 for epicatechin and 6.2 mug mL-1 for caffeic acid) from samples.	Water	63-68	L1 cell adhesion molecule	Mus musculus	300-304
30364970-3	2019	Among the compounds investigated, choline chloride-oxalic acid-water of DESs-H2O with various molar ratios with 1:0.1-1:50 showed the greatest change in viscosity with 3617-2 mPa s, and effectively extracted most of the target compounds of polyphenols (52.1 mug mL-1 for protocatechuic acid, 7.3 mug mL-1 for catechins, 34.0 mug mL-1 for epicatechin and 6.2 mug mL-1 for caffeic acid) from samples.	Water	77-80	L1 cell adhesion molecule	Mus musculus	262-266
30364970-3	2019	Among the compounds investigated, choline chloride-oxalic acid-water of DESs-H2O with various molar ratios with 1:0.1-1:50 showed the greatest change in viscosity with 3617-2 mPa s, and effectively extracted most of the target compounds of polyphenols (52.1 mug mL-1 for protocatechuic acid, 7.3 mug mL-1 for catechins, 34.0 mug mL-1 for epicatechin and 6.2 mug mL-1 for caffeic acid) from samples.	Water	77-80	L1 cell adhesion molecule	Mus musculus	300-304
30364970-3	2019	Among the compounds investigated, choline chloride-oxalic acid-water of DESs-H2O with various molar ratios with 1:0.1-1:50 showed the greatest change in viscosity with 3617-2 mPa s, and effectively extracted most of the target compounds of polyphenols (52.1 mug mL-1 for protocatechuic acid, 7.3 mug mL-1 for catechins, 34.0 mug mL-1 for epicatechin and 6.2 mug mL-1 for caffeic acid) from samples.	Water	77-80	L1 cell adhesion molecule	Mus musculus	300-304
30364970-3	2019	Among the compounds investigated, choline chloride-oxalic acid-water of DESs-H2O with various molar ratios with 1:0.1-1:50 showed the greatest change in viscosity with 3617-2 mPa s, and effectively extracted most of the target compounds of polyphenols (52.1 mug mL-1 for protocatechuic acid, 7.3 mug mL-1 for catechins, 34.0 mug mL-1 for epicatechin and 6.2 mug mL-1 for caffeic acid) from samples.	Water	77-80	L1 cell adhesion molecule	Mus musculus	300-304
30820155-3	2019	Aquaporin-3 (AQP3) is a membrane protein that contributes to the water homeostasis of the epidermis, and decreased AQP3 expression following ultraviolet (UV)-irradiation of the skin is associated with reduced skin moisture.	Water	65-70	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
20865058-4	2010	METHODS: The inhibitory effects of five types of cranberry juices were compared with those of water on CYP2C9 activity (S-warfarin 7-hydroxylation) in human liver microsomes (HLM).	Water	94-99	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	103-109
30820155-3	2019	Aquaporin-3 (AQP3) is a membrane protein that contributes to the water homeostasis of the epidermis, and decreased AQP3 expression following ultraviolet (UV)-irradiation of the skin is associated with reduced skin moisture.	Water	65-70	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
31184819-0	2019	The Effect of Cold Water Immersion on Cardiac Troponin T and Myoglobin Levels.	Water	19-24	myoglobin	Homo sapiens	61-70
20143423-10	2010	Less swelling in the brain and retina of the AR(-/-)db/db mice correlated with less expression of the water channel aquaporin 4.	Water	102-107	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	45-47
19889953-8	2010	We find that water permeability in cells expressing phosphorylation site mutants was in the following order: AQP2-S256D &gt; AQP2 wild-type &gt; AQP2-S256A.	Water	13-18	aquaporin 2	Canis lupus familiaris	109-113
19889953-8	2010	We find that water permeability in cells expressing phosphorylation site mutants was in the following order: AQP2-S256D &gt; AQP2 wild-type &gt; AQP2-S256A.	Water	13-18	aquaporin 2	Canis lupus familiaris	125-129
19889953-8	2010	We find that water permeability in cells expressing phosphorylation site mutants was in the following order: AQP2-S256D &gt; AQP2 wild-type &gt; AQP2-S256A.	Water	13-18	aquaporin 2	Canis lupus familiaris	125-129
20443661-1	2010	OBJECTIVE: This retrospective study was performed to characterize the laboratory features and water metabolism of women with pregnancy-induced antithrombin deficiency (PIATD).	Water	94-99	serpin family C member 1	Homo sapiens	143-155
31184819-3	2019	This study was conducted to investigate the effect of cold water immersion applied after exercise on cardiac troponin T and myoglobin levels.	Water	59-64	myoglobin	Homo sapiens	124-133
30658039-3	2019	Therefore, in this study, molecular dynamics (MD) simulations and free energy calculations were carried out to explore the interactions among water, agonist (DHT) or antagonist (HFT), AR, and coactivator (SRC3).	Water	142-147	nuclear receptor coactivator 3	Homo sapiens	205-209
20016287-5	2010	Metformin (0.5 mg/ml in drinking water) increased mean life span by 8% and MAC latency by 13.2% (p &lt; 0.05) in HER2/neu mice.	Water	33-38	erb-b2 receptor tyrosine kinase 2	Mus musculus	113-117
20016287-5	2010	Metformin (0.5 mg/ml in drinking water) increased mean life span by 8% and MAC latency by 13.2% (p &lt; 0.05) in HER2/neu mice.	Water	33-38	erb-b2 receptor tyrosine kinase 2	Mus musculus	118-121
20462264-0	2010	A study on the behavior of water droplet confined between an atomic force microscope tip and rough surfaces.	Water	27-32	TOR signaling pathway regulator	Homo sapiens	85-88
30529825-2	2019	The water extracts had the highest antioxidant activity, especially those from roots and flowers, and were further appraised for in vitro inhibition of enzymes implicated on the onset of human ailments, namely acetyl- (AChE) and butyrylcholinesterase (BuChE) for Alzheimer"s disease, alpha-glucosidase and alpha-amylase for diabetes, and tyrosinase for skin hyperpigmentation disorders.	Water	4-9	sucrase-isomaltase	Homo sapiens	284-301
20462264-2	2010	It is well-known that water condenses between an AFM tip and a solid surface, thereby generating a pull-off force acting on the tip.	Water	22-27	TOR signaling pathway regulator	Homo sapiens	53-56
19748238-6	2010	The results indicate that (1) the agonist is associated with the oil droplets in emulsion formulations, (2) the emulsion formulations containing synthetic TLR4 agonist induce higher IgG2a/IgG1 antibody ratios than aqueous formulations or an emulsion formulation without the agonist, and (3) appropriate plant-derived components can be substituted for animal-derived components in oil-in-water emulsions without loss of biological activity.	Water	387-392	toll like receptor 4	Homo sapiens	155-159
20462264-3	2010	We investigated the behavior of a water meniscus between the tip and a solid surface using molecular dynamics simulation.	Water	34-39	TOR signaling pathway regulator	Homo sapiens	61-64
30792750-12	2019	In the water phase, the level of MCP-1 was significantly decreased, while all of the other factors increased during the 4th through 6th months.	Water	7-12	C-C motif chemokine ligand 2	Homo sapiens	33-38
20462264-6	2010	The behavior of water confined between the tip and a solid surface depends on the characteristic energy of the solid surface, the tip-to-surface distance, and the shape of the solid surface.	Water	16-21	TOR signaling pathway regulator	Homo sapiens	43-46
20462264-6	2010	The behavior of water confined between the tip and a solid surface depends on the characteristic energy of the solid surface, the tip-to-surface distance, and the shape of the solid surface.	Water	16-21	TOR signaling pathway regulator	Homo sapiens	130-133
20528028-2	2010	The experiments were performed on a frozen solution of Gd(+3) (S=7/2) in water/glycerol.	Water	73-78	GRDX	Homo sapiens	55-61
32688718-12	2010	Only VvPIP2 and VvTIP proteins function as water channels with the exception of VvPIP2;5.	Water	43-48	aquaporin PIP2	Vitis vinifera	5-11
32688718-13	2010	VvPIP2;5 differs from the water conducting VvPIP2;1 by the substitution of two highly conserved amino acids in Loop B (G97S, G100W), which was shown by homology modelling to likely form a hydrophobic block of the water pore.	Water	213-218	aquaporin PIP2	Vitis vinifera	0-6
22081588-2	2010	Via the bloodstream, vasopressin reaches the collecting duct cells in the kidney, where the water channel Aquaporin-2 (AQP2) is expressed.	Water	92-97	aquaporin 2	Homo sapiens	106-117
30792750-13	2019	We found significantly higher EGF, GRO, and RANTES levels in the water fraction compared to the lipid fraction of the lipid phase.	Water	65-70	epidermal growth factor	Homo sapiens	30-33
22081588-2	2010	Via the bloodstream, vasopressin reaches the collecting duct cells in the kidney, where the water channel Aquaporin-2 (AQP2) is expressed.	Water	92-97	aquaporin 2	Homo sapiens	119-123
30694072-7	2019	The presence of water during anion exchange is found to have a deleterious effect on the Yb3+ PLQYs but does not affect the nanocrystal shapes or morphologies, or even reduce the excitonic PLQYs of analogous undoped CsPb(Cl1- xBr x)3 nanocrystals.	Water	16-21	granzyme B	Homo sapiens	216-220
20209436-7	2010	We also demonstrate that expression of Drosophila integrin protein (DRIP), an aquaporin responsible for trans-cellular water transport, is also reduced in stellate cells when ecdysone signaling is disrupted.	Water	119-124	drip	Drosophila melanogaster	39-66
20209436-7	2010	We also demonstrate that expression of Drosophila integrin protein (DRIP), an aquaporin responsible for trans-cellular water transport, is also reduced in stellate cells when ecdysone signaling is disrupted.	Water	119-124	drip	Drosophila melanogaster	68-72
20532040-4	2010	We found that sea anemones of chemosynthetic environments derive from at least two different lineages: one lineage including acontiate deep-sea taxa and the other primarily encompassing shallow-water taxa.	Water	194-199	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	14-17
30694072-7	2019	The presence of water during anion exchange is found to have a deleterious effect on the Yb3+ PLQYs but does not affect the nanocrystal shapes or morphologies, or even reduce the excitonic PLQYs of analogous undoped CsPb(Cl1- xBr x)3 nanocrystals.	Water	16-21	adhesion G protein-coupled receptor L1	Homo sapiens	221-224
30667002-0	2019	A water-soluble BODIPY based "OFF/ON" fluorescent probe for the detection of Cd2+ ions with high selectivity and sensitivity.	Water	2-7	CD2 molecule	Homo sapiens	77-80
20346911-0	2010	Determination of molecular groups involved in the interaction of annexin A5 with lipid membrane models at the air-water interface.	Water	114-119	annexin A5	Homo sapiens	65-75
19899781-0	2010	Role of water in molecular docking simulations of cytochrome P450 2D6.	Water	8-13	cytochrome P450 2D6	Homo sapiens	50-69
19899781-3	2010	In this study, the effects of including water molecules in molecular docking simulations of the important metabolic enzyme cytochrome P450 2D6 are investigated.	Water	40-45	cytochrome P450 2D6	Homo sapiens	123-142
30667002-1	2019	A water-soluble dilithium salt BODIPY derivative (LiBDP) with appended dicarboxylate pseudo-crown ether [NO4] coordinating sites has been designed, synthesized and characterized successfully for the selective and sensitive recognition of Cd2+ in aqueous media.	Water	2-7	CD2 molecule	Homo sapiens	238-241
20523002-0	2010	Synthesis of water-soluble polyamine derivatives effective as N-methyl-D-aspartate receptor antagonists.	Water	13-18	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	62-91
30667002-2	2019	The chemosensor exhibits a remarkable increase in fluorescence intensity as well as a distinct color change upon the addition of Cd2+ over other environmentally and biologically relevant metal ions in H2O.	Water	201-204	CD2 molecule	Homo sapiens	129-132
30645101-1	2019	Following our recent reports on the inhibition of the water and glycerol channel aquaglyceroporin-3 (AQP3) by the coordination complex [AuIII(1,10-phenanthroline)Cl2] (Auphen), a series of six new Au(III) complexes featuring substituted 1,10-phenanthroline ligands (1-6) have been synthesized and characterized.	Water	54-59	aquaporin 3 (Gill blood group)	Homo sapiens	101-105
19404754-8	2010	Tap water from the households hosted a much less diverse, low-cell bacterial assemblage, dominated by Mycobacterium-like phylotypes, related to biofilm bacterial communities.	Water	4-9	filamin B	Homo sapiens	0-3
20385965-3	2010	Here, using a mouse model of baroreflex impairment, we show that the increase in blood pressure after water ingestion is mediated through sympathetic nervous system activation and that the osmosensitive transient receptor potential vanilloid 4 channel (Trpv4) is an essential component of the response.	Water	102-107	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	253-258
20385965-4	2010	Although portal osmolality decreases after water ingestion in both wild-type and Trpv4(-/-) mice, only the wild-type animals show a pressor response.	Water	43-48	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	81-86
20816012-0	2010	Evaluation of protective effect of a water-in-oil microemulsion incorporating quercetin against UVB-induced damage in hairless mice skin.	Water	37-42	lysine demethylase and nuclear receptor corepressor	Mus musculus	118-126
19852935-8	2009	Coexpression of PKB/Akt and PIKfyve, but not of (S318A)PIKfyve, stimulated I(cAMP) in CFTR-expressing ( approximately 2- to 3-fold) but not in (DeltaF508)CFTR-expressing or water injected Xenopus oocytes.	Water	173-178	v-akt murine thymoma viral oncogene homolog 1 S homeolog	Xenopus laevis	16-19
19858203-5	2009	Furthermore, we show that increased expression of the water channel Aquoporin-1 is responsible for the deleterious consequences of excessive DAF-16-mediated immune response.	Water	54-59	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	141-147
19858203-6	2009	These studies reveal a stress-inducible mechanism involved in the regulation of DAF-16 and indicate that uncontrolled DAF-16 activity and water homeostasis are a cause of the deleterious effects of excessive immune responses.	Water	138-143	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	80-86
30621805-5	2019	Furthermore, brackish water (24 ppt) significantly promoted the mRNA levels of elongase 5 of very long-chain fatty acids (elovl5) and peroxisome proliferator-activated receptor alpha (pparalpha) in liver, when compared with freshwater.	Water	22-27	peroxisome proliferator-activated receptor alpha	Oreochromis niloticus	184-193
19891460-2	2009	Earlier studies have established that the condensation occurs with a syn addition of water to the si side of C2(PEP) and of C3(PEP) to the re side of C1(A5P).	Water	85-90	progestagen associated endometrial protein	Homo sapiens	109-116
19891460-2	2009	Earlier studies have established that the condensation occurs with a syn addition of water to the si side of C2(PEP) and of C3(PEP) to the re side of C1(A5P).	Water	85-90	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	150-156
19902545-6	2010	Gut capillary fragility and water export (stool blood and form) appear significantly earlier in Ang-2(-/-) + DSS mice vs. WT.	Water	28-33	angiopoietin 2	Mus musculus	96-101
19891460-4	2009	One involves a transient carbanion intermediate, formed by attack of water or a hydroxide ion on C2(PEP).	Water	69-74	progestagen associated endometrial protein	Homo sapiens	97-104
19891460-7	2009	In this study we calculated the potential energy surfaces (PESs) associated with all possible reaction paths in the active site of KDO8PS: the path involving a syn addition of water to the si side of C2(PEP) and of C3(PEP) to the re side of C1(A5P), with the PEP phosphate group deprotonated, has the lowest energy barrier ( approximately 14 kcal/mol) and is strongly exoergonic (reaction energy of -38 kcal/mol).	Water	176-181	progestagen associated endometrial protein	Homo sapiens	200-207
19891460-7	2009	In this study we calculated the potential energy surfaces (PESs) associated with all possible reaction paths in the active site of KDO8PS: the path involving a syn addition of water to the si side of C2(PEP) and of C3(PEP) to the re side of C1(A5P), with the PEP phosphate group deprotonated, has the lowest energy barrier ( approximately 14 kcal/mol) and is strongly exoergonic (reaction energy of -38 kcal/mol).	Water	176-181	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	241-247
19891460-8	2009	Consistent with the experimental observations, other potential reaction paths, like an anti addition of water to the re side of C2(PEP) or addition of C3(PEP) to the si side of C1(A5P), are associated with much higher barriers.	Water	104-109	progestagen associated endometrial protein	Homo sapiens	128-135
19891460-8	2009	Consistent with the experimental observations, other potential reaction paths, like an anti addition of water to the re side of C2(PEP) or addition of C3(PEP) to the si side of C1(A5P), are associated with much higher barriers.	Water	104-109	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	177-183
20234193-8	2010	Moreover, low-level 0.5 mg/ml PND-1186 ad libitum administration in drinking water prevented oncogenic KRAS- and BRAF-stimulated MDA-MB-231 breast carcinoma tumor growth and metastasis with inhibition of tumoral FAK and p130Cas phosphorylation.	Water	77-82	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	103-107
30389526-5	2019	We therefore performed multiple unconstrained MD simulations of cyt-c (PDB ID: 1HRC) in water and aqueous mixtures of GdmCl and urea for the period of 0-500 ns at 300, 400 and 450 K, which showed that denaturation of cyt-c by urea and GdmCl is a two-state and three-state process, respectively.	Water	88-93	cytochrome c, somatic	Equus caballus	64-69
20234193-8	2010	Moreover, low-level 0.5 mg/ml PND-1186 ad libitum administration in drinking water prevented oncogenic KRAS- and BRAF-stimulated MDA-MB-231 breast carcinoma tumor growth and metastasis with inhibition of tumoral FAK and p130Cas phosphorylation.	Water	77-82	Braf transforming gene	Mus musculus	113-117
19923889-10	2009	Therefore, this review will focus on H(2)O(2) modulating cell signaling via Prdxs by discussing: (1) the activity of Prdxs towards H(2)O(2); (2) sub cellular localization and availability of other peroxidases, such as catalase or glutathione peroxidases; (3) the availability of Prdxs reducing systems, such as thioredoxin and sulfiredoxin and lastly, (4) Prdx1 interacting signaling molecules.	Water	37-42	thioredoxin	Homo sapiens	311-322
30179812-9	2019	We note that failure to understand and account for actual water use behaviour may results in adverse public health outcomes and maladapted WASH policy and interventions.	Water	58-63	WASP family homolog 6, pseudogene	Homo sapiens	139-143
21468184-7	2009	Dysregulation of aquaporin-2 and sodium transporters also play an important role in the pathogenesis of renal sodium and water retention.	Water	121-126	aquaporin 2	Homo sapiens	17-28
20394352-2	2010	This issue is herein explored in experiments where the formation of Me(3)NH(+) on neat and doped water microjets exposed to Me(3)N(g) is monitored within &lt;1 ms by online electrospray ionization mass spectrometry as a function of pH of the bulk liquid (pH(BLK)).	Water	97-102	BLK proto-oncogene, Src family tyrosine kinase	Homo sapiens	258-261
20394352-3	2010	Notably, Me(3)N(g) is protonated on the surface of neat water microjets below pH(BLK) approximately 4, rather than at pH(BLK) less than or approximately pK(A)(Me(3)NH(+)) = 9.8 as in bulk water.	Water	56-61	BLK proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
30368848-4	2019	The results show that the EFP1-D and QM/EFP1-D binding energies are in good agreement with CCSD(T)/CBS binding energies with a mean absolute error of 5.9 kcal/mol for water clusters and 0.8 kcal/mol for solute-water binary complexes.	Water	167-172	thioredoxin domain containing 11	Homo sapiens	26-30
20428538-1	2010	Ellipsometry was employed to study the adsorption to the hexadecane-water interface of the simple non-ionic hydrocarbon surfactant C(10)E(8) and the two milk proteins beta-casein and beta-lactoglobulin, as well as the competitive adsorption of each protein with the surfactant.	Water	68-73	casein beta	Homo sapiens	167-178
20184566-8	2010	RESULTS: With qRT-PCR, the rats chronically drinking ethanol plus water compared to water alone showed significantly higher levels of ENK mRNA, not only in the PVN but also in the VTA, NAcSh, NAcC, and mPFC, although not in the CeA.	Water	66-71	proenkephalin	Rattus norvegicus	134-137
19651234-2	2009	These cells are the site of water reabsorption regulated by vasopressin and aquaporin-2 (AQP2) trafficking to the apical membrane, and subject to changes in osmolality.	Water	28-33	aquaporin 2	Canis lupus familiaris	76-87
19651234-2	2009	These cells are the site of water reabsorption regulated by vasopressin and aquaporin-2 (AQP2) trafficking to the apical membrane, and subject to changes in osmolality.	Water	28-33	aquaporin 2	Canis lupus familiaris	89-93
19395026-0	2009	OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus.	Water	0-4	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	109-112
20184566-8	2010	RESULTS: With qRT-PCR, the rats chronically drinking ethanol plus water compared to water alone showed significantly higher levels of ENK mRNA, not only in the PVN but also in the VTA, NAcSh, NAcC, and mPFC, although not in the CeA.	Water	84-89	proenkephalin	Rattus norvegicus	134-137
30368848-4	2019	The results show that the EFP1-D and QM/EFP1-D binding energies are in good agreement with CCSD(T)/CBS binding energies with a mean absolute error of 5.9 kcal/mol for water clusters and 0.8 kcal/mol for solute-water binary complexes.	Water	167-172	thioredoxin domain containing 11	Homo sapiens	40-44
19395026-0	2009	OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus.	Water	0-4	immunoglobulin kappa locus	Homo sapiens	131-134
30368848-4	2019	The results show that the EFP1-D and QM/EFP1-D binding energies are in good agreement with CCSD(T)/CBS binding energies with a mean absolute error of 5.9 kcal/mol for water clusters and 0.8 kcal/mol for solute-water binary complexes.	Water	210-215	thioredoxin domain containing 11	Homo sapiens	26-30
30368848-4	2019	The results show that the EFP1-D and QM/EFP1-D binding energies are in good agreement with CCSD(T)/CBS binding energies with a mean absolute error of 5.9 kcal/mol for water clusters and 0.8 kcal/mol for solute-water binary complexes.	Water	210-215	thioredoxin domain containing 11	Homo sapiens	40-44
20203161-2	2010	We tested the hypothesis that methylprednisolone treatment increased renal water and sodium absorption by increased absorption via the aquaporin-2 (AQP2) water channels and the epithelial sodium channels (ENaCs) respectively.	Water	154-159	aquaporin 2	Homo sapiens	135-146
20203161-2	2010	We tested the hypothesis that methylprednisolone treatment increased renal water and sodium absorption by increased absorption via the aquaporin-2 (AQP2) water channels and the epithelial sodium channels (ENaCs) respectively.	Water	154-159	aquaporin 2	Homo sapiens	148-152
26609989-0	2009	How Does the Relocation of Internal Water Affect Resonance Raman Spectra of Rhodopsin?	Water	36-41	rhodopsin	Bos taurus	76-85
26609989-2	2009	The effect of relocation of the W2 crystallographic water in bovine rhodopsin has been investigated by comparing and analyzing simulated resonance Raman spectra of 1HZX- and 1U19-based quantum mechanics/molecular mechanics (CASSCF/MM) models.	Water	52-57	rhodopsin	Bos taurus	68-77
26609989-4	2009	In particular, we focus on a quantitative investigation of the changes in the vibrational activity of rhodopsin induced by modifications in the protein cavity structure and in the water position.	Water	180-185	rhodopsin	Bos taurus	102-111
30227346-0	2019	Ligand free surface of CdS nanoparticles enhances the energy transfer efficiency on interacting with Eosin Y dye - Helping in the sensing of very low level of chlorpyrifos in water.	Water	175-180	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
20067179-0	2009	[Fibrillar part of C1q factor from the complement system has a great amount of bound water].	Water	85-90	complement C1q A chain	Homo sapiens	19-22
20183496-1	2009	The SPARC software program was validated for nitrogen-hydrogen acidity constant estimation of primary and secondary sulfonamides against a broad suite of substituted derivatives with experimental datasets in water and dimethylsulfoxide solvent systems and across a wide pK(a) range.	Water	208-213	secreted protein acidic and cysteine rich	Homo sapiens	4-9
20422004-7	2010	In vitro, overexpression of ecSOD, but not ecSOD-DeltaHBD, in cultured medium in ECs enhances VEGF-induced tyrosine phosphorylation of VEGFR2 (VEGFR2-pY), which is prevented by short-term pretreatment with catalase that scavenges extracellular H(2)O(2).	Water	244-249	superoxide dismutase 3, extracellular	Mus musculus	28-33
30516989-5	2019	The results are rationalized with a need for proper orientation of the reactants in the hydrated system, with formation of a Mg2+(CO4)-(H2O) n intermediate while the activation energy is negligible.	Water	136-139	complement C4A (Rodgers blood group)	Homo sapiens	130-133
20130117-6	2010	All the NSAIDs decreased AQP2 expression significantly in water-restricted rats but did not significantly alter PGE excretion.	Water	58-63	aquaporin 2	Rattus norvegicus	25-29
19555721-10	2009	The recovery of MS2, HAV and NV was significantly higher from concentrates obtained from water with treated devices than untreated devices but not significantly different for FCV or from spinach eluate.	Water	89-94	MS2	Homo sapiens	16-19
30634575-8	2019	The developed sensor is simple, cost effective, highly sensitive, and extremely selective for As3+ detection, showing a low detection limit (LDL) of 1.6 x 10-8 M. The developed sensor was effectively tested for detection of As3+ in some water samples.	Water	237-242	PDS5 cohesin associated factor B	Homo sapiens	224-227
20089674-1	2010	The action of vasopressin in rodent collecting ducts to regulate water permeability depends in part on increases in phosphorylation of the water channel aquaporin-2 (AQP2) at three sites: Ser256, Ser264, and Ser269.	Water	65-70	aquaporin 2	Rattus norvegicus	153-164
20089674-1	2010	The action of vasopressin in rodent collecting ducts to regulate water permeability depends in part on increases in phosphorylation of the water channel aquaporin-2 (AQP2) at three sites: Ser256, Ser264, and Ser269.	Water	65-70	aquaporin 2	Rattus norvegicus	166-170
19486933-1	2009	The preparation of tablets by the melt granulation process was investigated to enhance chemical stability of a highly water-soluble drug substance, dipeptidylpeptidase IV (DPP-IV) inhibitor (Compound I), that is susceptible to degradation in presence of moisture.	Water	118-123	dipeptidyl peptidase 4	Homo sapiens	148-170
20089674-1	2010	The action of vasopressin in rodent collecting ducts to regulate water permeability depends in part on increases in phosphorylation of the water channel aquaporin-2 (AQP2) at three sites: Ser256, Ser264, and Ser269.	Water	139-144	aquaporin 2	Rattus norvegicus	153-164
19486933-1	2009	The preparation of tablets by the melt granulation process was investigated to enhance chemical stability of a highly water-soluble drug substance, dipeptidylpeptidase IV (DPP-IV) inhibitor (Compound I), that is susceptible to degradation in presence of moisture.	Water	118-123	dipeptidyl peptidase 4	Homo sapiens	172-178
20089674-1	2010	The action of vasopressin in rodent collecting ducts to regulate water permeability depends in part on increases in phosphorylation of the water channel aquaporin-2 (AQP2) at three sites: Ser256, Ser264, and Ser269.	Water	139-144	aquaporin 2	Rattus norvegicus	166-170
31055574-4	2019	RESULTS: Intradialytic fall of plasma water beta2M levels (corrected for rebound) was 65.2 +- 2.6% in HDF, 49.8 +- 9.1% in BHD, and 32.3 +- 6.4% in NSO (p &lt; 0.001 between all groups).	Water	38-43	beta-2-microglobulin	Homo sapiens	44-50
20085484-1	2010	Glutathione S-transferases (GSTs) constitute a family of detoxification enzymes that catalyze the conjugation of glutathione with a variety of hydrophobic compounds, including drugs and their metabolites, to yield water-soluble derivatives that are excreted in urine or bile.	Water	214-219	glutathione S-transferase kappa 1	Homo sapiens	28-32
19705110-4	2009	The data obtained suggested that the low water-soluble, non-polar pesticide rotenone resulted preferentially adsorbed onto HAs by hydrophobic interaction, that was the prevailing mechanism in the order HA S1 &gt; HA S2 &gt;&gt;&gt; HA SR, whereas hydrogen bonds resulted predominant in the opposite order.	Water	41-46	hyaluronan synthase 1	Homo sapiens	202-207
31177217-6	2019	Spatial learning decline was prevented in the Abeta+ immunized group in an extended reference memory version of Morris water maze test from 21 to 57 weeks.	Water	119-124	amyloid beta (A4) precursor protein	Mus musculus	46-51
19681073-3	2009	Bio-inspired by the cluster presentation of gp120, we have designed and prepared a small library of multivalent water-soluble gold glyconanoparticles (manno-GNPs) presenting truncated (oligo)mannosides of the high-mannose undecasaccharide Man(9)GlcNAc(2) and have tested them as inhibitors of DC-SIGN binding to gp120.	Water	112-117	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	44-49
19681073-3	2009	Bio-inspired by the cluster presentation of gp120, we have designed and prepared a small library of multivalent water-soluble gold glyconanoparticles (manno-GNPs) presenting truncated (oligo)mannosides of the high-mannose undecasaccharide Man(9)GlcNAc(2) and have tested them as inhibitors of DC-SIGN binding to gp120.	Water	112-117	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	312-317
20172967-10	2010	Metabolically the Ebf1(-/-) mice had increased O(2) consumption, CO(2) production, food and water intake, and activity.	Water	92-97	early B cell factor 1	Mus musculus	18-22
20138968-12	2010	Furthermore, there were high correlations between the brain water content with the serum albumin level, with serum VEGF protein level, and with brain VEGF mRNA expression at 24 h after MCAO.	Water	60-65	vascular endothelial growth factor A	Rattus norvegicus	115-119
30352763-7	2019	The spatial learning and memory were analyzed by means of the Morris water maze test (MWM), The results showed that the swimming velocity, distance traveled and latency to reach the platform in SCA3 mice were increased when compared with WT mice during the 4 training days (p < 0.05, 0.01 or 0.001).	Water	69-74	ataxin 3	Mus musculus	194-198
20138968-12	2010	Furthermore, there were high correlations between the brain water content with the serum albumin level, with serum VEGF protein level, and with brain VEGF mRNA expression at 24 h after MCAO.	Water	60-65	vascular endothelial growth factor A	Rattus norvegicus	150-154
20194770-6	2010	Two hundred trajectories of myosin with explicit water solvation are used to sample transitions between sequential pairs of Milestones.	Water	49-54	myosin heavy chain 14	Homo sapiens	28-34
20141116-6	2010	Resemblance to computed representative conformations of CD26 in water was found for CD27 and CD28, with the similarity being better expressed for the former case.	Water	64-69	dipeptidyl peptidase 4	Homo sapiens	56-60
20141116-6	2010	Resemblance to computed representative conformations of CD26 in water was found for CD27 and CD28, with the similarity being better expressed for the former case.	Water	64-69	CD27 molecule	Homo sapiens	84-88
19727498-12	2009	In contrast, GTS, TS, and TC1 required relative humidity well in excess of water saturation at -40 degrees C for ice formation.	Water	75-80	transcobalamin 1	Homo sapiens	26-29
19580781-3	2009	On simulating the native form and mutants (A30P, E46K and A53T) of alpha-synuclein in water solvent, clear deviations are observed in comparison to the all-helical 1XQ8 PDB structure.	Water	86-91	synuclein alpha	Homo sapiens	67-82
19819829-9	2009	Water solubility of the prepared complex was found to be 22.1 microg mL-1 as compared to 10.5 microg mL-1 of diclofenac.	Water	0-5	L1 cell adhesion molecule	Mus musculus	69-73
30362641-4	2019	In the case of compounds displaying an acetoxy group at C-4, product ion C produces diagnostic ions K ([C-C2 H2 O]+ ), L ([K-CO]+ ), and P ([L-CO]+ ).	Water	109-113	complement C4A (Rodgers blood group)	Homo sapiens	56-59
19318428-2	2009	In the kidney, vasopressin (Vp) is a critical regulator of water homeostasis by controlling the insertion of aquaporin 2 (AQP2) onto the apical membrane of the collecting duct principal cells in the short term and regulating the gene expression of AQP2 in the long term.	Water	59-64	aquaporin 2	Homo sapiens	122-126
30242840-6	2019	Taken together, the findings reveal NHA2 as a potential new player in salt and water homeostasis in the kidney and in the pathogenesis of polycystic kidney disease.	Water	79-84	solute carrier family 9 member B2	Homo sapiens	36-40
19810459-6	2009	Simulations of water-kerma and dose in water for the CSA1, CSA2, RTR, 3M, and selectron/ LDR 137Cs sources are carried out using the DOSRZnrc code.	Water	39-44	IK cytokine	Homo sapiens	59-63
20056751-5	2010	The knockout mice had reduced levels of mRNA, protein, and membrane localization of the vasopressin-responsive water channel aquaporin 2 compared with wild-type mice.	Water	111-116	aquaporin 2	Mus musculus	125-136
30472169-7	2019	The detected complexes in the cCa fraction are mainly Ca(eta2-HPO4)(H2O)4 and Ca(eta1-HCO3)(H2O)5+, in which HPO42- and HCO3- serve as bidentate and unidentate ligands, respectively.	Water	92-95	secreted phosphoprotein 1	Homo sapiens	81-85
19650071-9	2010	Subsequently, HSMD was applied to mobile loops of the enzymes porcine pancreatic alpha-amylase and acetylcholinesterase in explicit water, where the difference in F between the bound and free states of the loop was calculated.	Water	132-137	amylase alpha 2A	Homo sapiens	70-94
19719261-7	2009	To this end, we studied by differential scanning calorimetry the thermal denaturation of ferric myoglobin in water/disaccharide mixtures containing nonreducing (trehalose, sucrose) or reducing (maltose, lactose) disaccharides.	Water	109-114	myoglobin	Homo sapiens	96-105
31814546-5	2019	Water bodies especially the sea and ocean are under investigation to find agents which can tackle inflammation.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	28-31
19403319-3	2009	In the present study, we determined the structure of uPA and uPAR complex in water and investigated the specific interactions between uPA and uPAR by ab initio molecular orbital (MO) calculations based on fragment MO method.	Water	77-82	plasminogen activator, urokinase receptor	Homo sapiens	61-65
19403319-5	2009	The influence of crystal water molecules existing between uPA and uPAR was also investigated to be significant on the specific interactions between uPA and uPAR.	Water	25-30	plasminogen activator, urokinase receptor	Homo sapiens	66-70
19403319-5	2009	The influence of crystal water molecules existing between uPA and uPAR was also investigated to be significant on the specific interactions between uPA and uPAR.	Water	25-30	plasminogen activator, urokinase receptor	Homo sapiens	156-160
18571773-3	2010	By using osmotic pumps, we have shown that in aged rats, IGF-I treatment in the third ventricle for four weeks increases water intake and restores diuresis and AVP plasma release similar with that observed in adults.	Water	121-126	insulin-like growth factor 1	Rattus norvegicus	57-62
31366848-8	2019	The SNP analysis process using this optimized water-soluble paper will be applied to gene polymorphism analysis of drug metabolizing enzyme gene CYP, etc., to help efforts to realize personalized medicine.	Water	46-51	peptidylprolyl isomerase G	Homo sapiens	145-148
20061449-8	2010	Activities of the water-extractable enzymes oxalate oxidase, peroxidase, and polyphenol oxidase were highest in the outer layers, whereas chitinase activity was found only in assays of whole grains.	Water	18-23	peroxidase-like	Triticum aestivum	61-71
19395011-9	2009	(4) AQP5 water channels were present in the apical plasma membrane of uterine epithelial cells in coincidence with plasma progesterone increase.	Water	9-14	aquaporin 5	Homo sapiens	4-8
30398300-0	2018	Confined Pt1 1+ Water Clusters in a MOF Catalyze the Low-Temperature Water-Gas Shift Reaction with both CO2 Oxygen Atoms Coming from Water.	Water	69-74	zinc finger protein 77	Homo sapiens	9-12
19624212-6	2009	The empty hydrates sII and sH appear to be the stable solid phases of water at negative pressures.	Water	70-75	transcription elongation factor A1	Homo sapiens	19-22
30398300-0	2018	Confined Pt1 1+ Water Clusters in a MOF Catalyze the Low-Temperature Water-Gas Shift Reaction with both CO2 Oxygen Atoms Coming from Water.	Water	69-74	zinc finger protein 77	Homo sapiens	9-12
30398300-2	2018	Herein, we show a gram-scale wet synthesis of Pt1 1+ stabilized in a confined space by a crystallographically well-defined first water sphere, and with a second coordination sphere linked to a metal-organic framework (MOF) through electrostatic and H-bonding interactions.	Water	129-134	zinc finger protein 77	Homo sapiens	46-49
19544511-1	2009	The pH-induced self-assembly of three synthetic tripeptides in water medium is used to immobilize luminescent CdS nanoparticles.	Water	63-68	CDP-diacylglycerol synthase 1	Homo sapiens	110-113
30553249-1	2018	Computational strategies aimed at unveiling the thermodynamic and kinetic properties of G Protein-Coupled Receptor (GPCR) activation require extensive molecular dynamics simulations of the receptor embedded in an explicit lipid-water environment.	Water	228-233	C-X-C motif chemokine receptor 6	Homo sapiens	88-114
26610015-3	2009	Calculations of the cis-trans chromophore isomerization pathway in the gas phase and in water reveal a problematic behavior of density functional theory and scaled opposite-spin-MP2 due to the multiconfigurational character of the wave function at twisted geometries.	Water	88-93	tryptase pseudogene 1	Homo sapiens	178-181
30553249-1	2018	Computational strategies aimed at unveiling the thermodynamic and kinetic properties of G Protein-Coupled Receptor (GPCR) activation require extensive molecular dynamics simulations of the receptor embedded in an explicit lipid-water environment.	Water	228-233	C-X-C motif chemokine receptor 6	Homo sapiens	116-120
30358055-3	2018	Demonstrated herein is the incorporation of a natural flavin cofactor (FMN) into the specific microenvironment of a water-soluble polymer which allows the efficient reduction of the FMN by NADH in aqueous solution.	Water	116-121	formin 1	Homo sapiens	71-74
18836965-2	2009	These results suggest that VP increases the influx of water from the perlymph to the basal cells via aquaporin (AQP) 2 and causes the formation of endolymphatic hydrops.	Water	54-59	aquaporin 2	Rattus norvegicus	112-118
19401454-9	2009	Treatment with H(2)O(2) increased the abundance of NOX2, HSF1, and PAI-1 in EC.	Water	15-20	serpin family E member 1	Homo sapiens	67-72
30358055-3	2018	Demonstrated herein is the incorporation of a natural flavin cofactor (FMN) into the specific microenvironment of a water-soluble polymer which allows the efficient reduction of the FMN by NADH in aqueous solution.	Water	116-121	formin 1	Homo sapiens	182-185
30454900-8	2018	Compared to the WT/ICH group, Rnf112-/- mice exhibited accelerated brain injury, as evidenced by the increased brain water contents and neurological deficit scores (NDS).	Water	117-122	ring finger protein 112	Mus musculus	30-36
19297367-3	2009	Several reports showed that a moderate expression of aquaporin 7 (AQP7), a member of the aquaglyceroporin family that is permeated by glycerol and water, is observed in heart tissue.	Water	147-152	aquaporin 7	Mus musculus	53-64
19297367-3	2009	Several reports showed that a moderate expression of aquaporin 7 (AQP7), a member of the aquaglyceroporin family that is permeated by glycerol and water, is observed in heart tissue.	Water	147-152	aquaporin 7	Mus musculus	66-70
19297368-3	2009	Ang1 decreased water permeability (L(P): hydraulic conductivity) in continuous and fenestrated microvessels and increased the retention of albumin (sigma: reflection coefficient) in continuous microvessels.	Water	15-20	angiopoietin 1	Rattus norvegicus	0-4
30243219-1	2018	N-acetylcysteine modified hyaluronic acid-paclitaxel (NAC-HA-PTX) conjugate was designed to improve the water solubility and oral bioavailability of PTX through mucosal bioadhesion ability.	Water	104-109	synuclein alpha	Homo sapiens	54-57
19423692-8	2009	In summary, these data suggest that AQP2-mediated water transport is downregulated not only by basolateral nucleotides, mediated by P2Y(2) receptors, but also by luminal nucleotides, mediated by P2X(2) and/or P2Y(4) receptors.	Water	50-55	aquaporin 2	Mus musculus	36-40
30306288-2	2018	Here we show, on the example of the intrinsically disordered protein alpha-synuclein and the folded domain PDZ2, that at physiological pH and near physiological temperatures amide-water exchange can severely skew Hahn-echo based 15N R2 relaxation measurements as well as low frequency data points in CPMG relaxation dispersion experiments.	Water	180-185	synuclein alpha	Homo sapiens	69-84
19403703-0	2009	Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site.	Water	42-47	aquaporin 4	Rattus norvegicus	30-41
19403703-1	2009	Aquaporin (AQP) water channels, essential for fluid homeostasis, are expressed in perivascular brain end-feet regions of astroglia (AQP4) and in choroid plexus (AQP1).	Water	16-21	aquaporin 4	Rattus norvegicus	132-136
19403703-9	2009	In silico docking of AqB013 supported an intracellular candidate binding site in rat AQP4 and suggested that the block involves occlusion of the AQP water pore at the cytoplasmic side.	Water	149-154	aquaporin 4	Rattus norvegicus	85-89
29909225-5	2018	The depth distribution of 129I in the water column of the South China Sea reflects the effluence of different currents.	Water	38-43	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	70-73
19461037-2	2009	We validated CBF(MRI) on quantitative CBF measurement by 15O-water positron emission tomography (CBF(PET)).	Water	61-66	CCAAT enhancer binding protein zeta	Homo sapiens	97-105
30540265-5	2018	At the genus level, the proportions of the different bacteria in drinking water may affect the degradation of the SM1/SMZ.	Water	74-79	SM1	Homo sapiens	114-121
19429374-9	2009	In addition, ACE decreased the intake of food and water, and did not increase body weight gain whereas rosiglitazone did.	Water	50-55	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	13-16
30540265-6	2018	The growth of bacteria in drinking water can be inhibited after the addition of SM1/SMZ, and bacterial community diversity in drinking water declined in this study.	Water	35-40	SM1	Homo sapiens	80-87
30540265-7	2018	Furthermore, the resistance gene sul2 was induced by SM1 in the drinking water.	Water	73-78	SM1	Homo sapiens	53-56
19358859-5	2009	MAIN METHODS: HFD-fed WT and GLP-1R(-/-) mice were treated with or without DPP-IV inhibitor by drinking water.	Water	104-109	dipeptidylpeptidase 4	Mus musculus	75-81
30253196-2	2018	We have previously shown that a water extract of Centella asiatica (CAW) attenuates beta-amyloid (Abeta)-induced spatial memory deficits in mice and improves neuronal health.	Water	32-37	amyloid beta (A4) precursor protein	Mus musculus	98-103
19456165-4	2009	Addition of water/THF followed by NBS results in formation of pyranones with ee"s &gt;90% and yields between 46-77%.	Water	12-17	nibrin	Homo sapiens	34-37
31131334-4	2018	Results: The calculated CSDA ranges by MCNPX and TRIM in water were first benchmarked to International Commission on Radiation Units and Measurement 49 published data for water, and found to be within 1% with a 1.4-mm maximum difference.	Water	57-62	Y-box binding protein 3	Homo sapiens	24-28
19425556-6	2009	Classical transition-state theory with Eckart tunneling corrections (TST/Eckart) predicts the intermediate --&gt; TS step to be about 3 to 6 orders of magnitude faster for the (1)[X-C-H] + 2H(2)O reactions than for the corresponding 1 water molecule cases.	Water	235-240	thiosulfate sulfurtransferase	Homo sapiens	69-72
31131334-4	2018	Results: The calculated CSDA ranges by MCNPX and TRIM in water were first benchmarked to International Commission on Radiation Units and Measurement 49 published data for water, and found to be within 1% with a 1.4-mm maximum difference.	Water	171-176	Y-box binding protein 3	Homo sapiens	24-28
30028042-13	2018	The results obtained indicate that AQP4 takes part in the regulation of water transport required for the formation of egg in the chicken oviduct.	Water	72-77	aquaporin 4	Gallus gallus	35-39
19465296-8	2009	In the 2 groups in which a water-based pen was used, the corneal flap was easily lifted.	Water	27-32	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	39-42
30426131-2	2018	Our experiments show that, in comparison to the reported literature, other cobalt-containing structures on the surface of the FTO electrode could also be the true catalyst for water oxidation.	Water	176-181	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	126-129
19483146-1	2009	The authors describe how room temperature storage of a 1120-member compound library prepared in either DMSO or in a hydrated-DMSO/water (67/33) mixture affects the reproducibility of potency values as monitored using cytochrome P450 1A2 and 2D6 isozyme assays.	Water	130-135	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	217-236
30538473-9	2018	Conclusion: PepT-1-mediated micelles, using PepT1 as a target on intestinal epithelium, have unique functions with intestine and prove promising for oral delivery of poorly water-soluble drugs.	Water	173-178	solute carrier family 15 member 1	Rattus norvegicus	12-18
18951371-1	2009	Allurin, a sperm chemoattractant isolated from Xenopus laevis egg jelly, can be purified in one step from an extract of diffusible jelly proteins ("egg water") using a FPLC or HPLC anion exchange column and a multi-step NaCl gradient.	Water	152-157	cysteine-rich secretory protein 1 gene 8 S homeolog	Xenopus laevis	0-7
18951371-6	2009	Rather, the presence of a multiphasic dose-activity curve upon partial purification and formation of hetero-allurin complexes during concentration suggested that egg water may contain allurin-binding proteins that reduce multimer formation and activity.	Water	166-171	cysteine-rich secretory protein 1 gene 8 S homeolog	Xenopus laevis	108-115
18951371-6	2009	Rather, the presence of a multiphasic dose-activity curve upon partial purification and formation of hetero-allurin complexes during concentration suggested that egg water may contain allurin-binding proteins that reduce multimer formation and activity.	Water	166-171	cysteine-rich secretory protein 1 gene 8 S homeolog	Xenopus laevis	184-191
30538473-9	2018	Conclusion: PepT-1-mediated micelles, using PepT1 as a target on intestinal epithelium, have unique functions with intestine and prove promising for oral delivery of poorly water-soluble drugs.	Water	173-178	solute carrier family 15 member 1	Rattus norvegicus	44-49
19341753-1	2009	Aquaporin (AQP) 9 is a member of the aquaglyceroporin subfamily of AQPs in the transfer of water and small solutes such as glycerol and arsenite.	Water	91-96	aquaporin 9	Mus musculus	0-17
30419927-6	2018	TBFat (kg) demonstrated to have a significant relation with the interaction diet-gene (p = 0.04), whereas FTO was associated with the variation of total body water (p = 0.02).	Water	158-163	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	106-109
19422184-1	2009	Theoretical calculations have been carried out using ab initio MP2 and B3LYP density functional methods to investigate the interaction between fluorinated dimethyl ethers (nF = 1-5) and water.	Water	186-191	tryptase pseudogene 1	Homo sapiens	63-66
30628247-5	2018	The water-air interface F(CO2) showed significant hourly, daily, and seasonal variations.	Water	4-9	complement C2	Homo sapiens	24-29
19433801-0	2009	Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors.	Water	10-16	rhodopsin	Bos taurus	75-84
20072781-8	2010	In contrast, mice lacking the alpha7 nAChR receptor subunit consumed significantly less ethanol than wild-type mice but consumed comparable amounts of water, saccharin, and quinine.	Water	151-156	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	30-36
20108956-12	2010	Large binding energies of sodium methyl sulfate (SMS)-(NaCl)(4), H(2)O-(NaCl)(4), and SMS-H(2)O-(NaCl)(4) calculated at the MP2/cc-pVDZ level suggested that placing H(2)O in between NaCl and surfactant headgroup is energetically favorable.	Water	65-70	tryptase pseudogene 1	Homo sapiens	124-127
29132261-6	2018	In addition, the results demonstrate that H bonds with Lys232, Glu245, Tyr249, His283, Asp351, and one structural water molecule play an important role for the inhibition of ALK-5.	Water	114-119	transforming growth factor beta receptor 1	Homo sapiens	174-179
20108956-12	2010	Large binding energies of sodium methyl sulfate (SMS)-(NaCl)(4), H(2)O-(NaCl)(4), and SMS-H(2)O-(NaCl)(4) calculated at the MP2/cc-pVDZ level suggested that placing H(2)O in between NaCl and surfactant headgroup is energetically favorable.	Water	90-95	tryptase pseudogene 1	Homo sapiens	124-127
20108956-12	2010	Large binding energies of sodium methyl sulfate (SMS)-(NaCl)(4), H(2)O-(NaCl)(4), and SMS-H(2)O-(NaCl)(4) calculated at the MP2/cc-pVDZ level suggested that placing H(2)O in between NaCl and surfactant headgroup is energetically favorable.	Water	90-95	tryptase pseudogene 1	Homo sapiens	124-127
19232637-10	2009	The variable size of the particles, obtained in a water methanol system, was employed for SERS measurement.	Water	50-55	seryl-tRNA synthetase 1	Homo sapiens	90-94
19425790-1	2009	Vibrational energy relaxation of HOD in deuterated water is investigated performing classical nonequilibrium molecular dynamics simulations.	Water	51-56	HOP homeobox	Homo sapiens	33-36
20178744-4	2010	The localized inactivation of PrxI allows for the transient accumulation of H(2)O(2) around membranes, where signaling components are concentrated, while preventing the toxic accumulation of H(2)O(2) elsewhere.	Water	76-81	peroxiredoxin 1	Mus musculus	30-34
29148316-0	2018	Recognition dynamics of trinuclear copper cluster and associated histidine residues through conserved or semi-conserved water molecules in human Ceruloplasmin: The involvement of aspartic and glutamic acid gates.	Water	120-125	ceruloplasmin	Homo sapiens	145-158
30305310-0	2018	Bile Acid G Protein-Coupled Membrane Receptor TGR5 Modulates Aquaporin 2-Mediated Water Homeostasis.	Water	82-87	aquaporin 2	Mus musculus	61-72
19969073-7	2010	Cells lacking both catalase and Gpx1 were more sensitive to exogenous H(2)O(2) than cells lacking only catalase.	Water	70-75	glutathione peroxidase 1	Mus musculus	32-36
19969073-8	2010	A kinetic model proposed earlier to rationalize results with Gpx1(-/-) erythrocytes also fits the data with Prdx2(-/-) cells and indicates that although Gpx1 and Prdx2 both participate in removing endogenous H(2)O(2), Prdx2 plays a larger role.	Water	208-213	glutathione peroxidase 1	Mus musculus	153-157
19402731-4	2009	The models of BChE tetramer complexed with PRAD with various sequences have been constructed, in the present study, on the basis of homology modeling and molecular dynamics simulation of explicit water-solvated systems.	Water	196-201	butyrylcholinesterase	Homo sapiens	14-18
30075304-7	2018	Accordingly, a value of approximately 25 kg CO2eq per m3 of treated water is determined for laboratory scale, compared to only 5 kg CO2eq per m3 at full-scale.	Water	68-73	complement C2	Homo sapiens	44-47
19590775-1	2009	The first step of the base-promoted decomposition of N-chloro,N-methylethanolamine in aqueous solution (CH3N(Cl)CH2CH2OH + HO- --&gt; imine + Cl- + H2O (+ CH2O) --&gt; amine + aldehyde) is investigated at the MP2/6-31++G(d,p) computing level.	Water	116-119	tryptase pseudogene 1	Homo sapiens	209-212
19996160-2	2010	The regulation occurs in part via control of transcription of genes coding for the water channels aquaporin-2 (Aqp2) and aquaporin-3 (Aqp3).	Water	83-88	aquaporin 2	Rattus norvegicus	98-109
19996160-2	2010	The regulation occurs in part via control of transcription of genes coding for the water channels aquaporin-2 (Aqp2) and aquaporin-3 (Aqp3).	Water	83-88	aquaporin 2	Rattus norvegicus	111-115
19225050-0	2009	mPGES-1 deletion impairs diuretic response to acute water loading.	Water	52-57	prostaglandin E synthase	Mus musculus	0-7
30086933-3	2018	The development of sensitive and reliable methods to detect As3+ in water is of great importance to biochemical research and monitoring applications.	Water	68-73	PDS5 cohesin associated factor B	Homo sapiens	60-63
19225050-2	2009	The present study was undertaken to examine the role of microsomal prostaglandin E synthase-1 (mPGES-1) in the diuretic response to acute and chronic water loading.	Water	150-155	prostaglandin E synthase	Mus musculus	56-93
19225050-2	2009	The present study was undertaken to examine the role of microsomal prostaglandin E synthase-1 (mPGES-1) in the diuretic response to acute and chronic water loading.	Water	150-155	prostaglandin E synthase	Mus musculus	95-102
19225050-3	2009	Compared with wild-type (+/+) controls, mPGES-1 -/- mice exhibited impaired ability to excrete an acute, but not chronic water load.	Water	121-126	prostaglandin E synthase	Mus musculus	40-47
19225050-7	2009	In response to acute water loading, renal AQP2 expression in the +/+ mice was significantly reduced, and this reduction was blunted in the -/- mice.	Water	21-26	aquaporin 2	Mus musculus	42-46
19225050-9	2009	Overall, these data support an important role of mPGES-1 in provoking the diuretic response to acute water loading.	Water	101-106	prostaglandin E synthase	Mus musculus	49-56
19831719-1	2010	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) is known to interact with aquaporin 4 (AQP 4), a water-selective transporting protein that is abundant in astrocytes, and has experimentally been found to decrease osmotically-induced cell swelling.	Water	118-123	aquaporin 4	Rattus norvegicus	95-106
19831719-1	2010	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) is known to interact with aquaporin 4 (AQP 4), a water-selective transporting protein that is abundant in astrocytes, and has experimentally been found to decrease osmotically-induced cell swelling.	Water	118-123	aquaporin 4	Rattus norvegicus	108-113
20002318-1	2010	Experimental evidence demonstrates a higher efficiency of water and nitrogen use in C(4) compared with C(3) plants, which is hypothesized to drive differences in biomass allocation between C(3) and C(4) species.	Water	58-63	complement C4A (Rodgers blood group)	Homo sapiens	84-88
20002318-1	2010	Experimental evidence demonstrates a higher efficiency of water and nitrogen use in C(4) compared with C(3) plants, which is hypothesized to drive differences in biomass allocation between C(3) and C(4) species.	Water	58-63	complement C4A (Rodgers blood group)	Homo sapiens	198-202
19366596-1	2009	Ion distribution in the selectivity filter and ion-water and ion-protein interactions of NaK channel are systematically investigated by all-atom molecular dynamics simulations, with the tetramer channel protein being embedded in a solvated phospholipid bilayer.	Water	51-56	TANK binding kinase 1	Homo sapiens	89-92
30086933-8	2018	The results shown herein have important implications in the development of new fluorescent sensors for the fast, easy, and selective detection and quantification of As3+ in water samples.	Water	173-178	PDS5 cohesin associated factor B	Homo sapiens	165-168
30380640-9	2018	However, administration of aloin suppressed liver injury as well as Muller cell swelling through the normalization of Kir4.1 and aquaporin-4 channels, which play a key role in potassium and water transport in Muller cells.	Water	190-195	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	118-124
19371384-3	2009	Under our conditions, 92.5% of the dissociated animal cap cells treated with the conditioned medium from H(2)O-injected control oocytes differentiated into neural tissue, which developed neural fibers and expressed a neural marker (NCAM).	Water	105-110	neural cell adhesion molecule 1 S homeolog	Xenopus laevis	232-236
20002318-4	2010	C(4) species had lower stomatal conductance and water potential deficits, and higher water-use efficiency than C(3) species.	Water	48-53	complement C4A (Rodgers blood group)	Homo sapiens	0-4
30380640-9	2018	However, administration of aloin suppressed liver injury as well as Muller cell swelling through the normalization of Kir4.1 and aquaporin-4 channels, which play a key role in potassium and water transport in Muller cells.	Water	190-195	aquaporin 4	Rattus norvegicus	129-140
20014840-6	2010	The three oxidation states present in the range of water stability are At(-I), At(+I), and At(+III) and exist as At(-), At(+), and AtO(+), respectively, in the 1-2 pH range.	Water	51-56	serpin family C member 1	Homo sapiens	91-98
19386895-6	2009	Loss of profilaggrin or filaggrin leads to a poorly formed stratum corneum (ichthyosis), which is also prone to water loss (xerosis).	Water	112-117	filaggrin	Homo sapiens	11-20
30365514-3	2018	However, variability in residual sea level up-estuary, defined here as observed sea level minus predicted tide, can enhance total water levels; variability in the surge thus needs to be captured accurately to reduce uncertainty in site specific hazard assessment.	Water	130-135	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	33-36
19685756-7	2009	RESULT: The levels of FBG, GSP and the amount of water drinking, food intake, urinary volume in the PSP treated groups were obviously lower than those in the model group while INS increased.	Water	49-54	persephin	Rattus norvegicus	100-103
30365514-3	2018	However, variability in residual sea level up-estuary, defined here as observed sea level minus predicted tide, can enhance total water levels; variability in the surge thus needs to be captured accurately to reduce uncertainty in site specific hazard assessment.	Water	130-135	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	80-83
20847461-2	2010	This relation has been suggested on the basis of two epidemiologic investigations which found an increased risk of ALS associated with residence in a seleniferous area or with consumption of drinking water with unusually high levels of inorganic hexavalent Se, in South Dakota and in northern Italy respectively.	Water	200-205	squalene epoxidase	Homo sapiens	257-259
30204420-2	2018	Here we show that highly water soluble (&gt;15 mg.mL-1) beta-sheets can be obtained via nucleotide monophosphate grafting onto simple poly(gamma-propargyl- L-glutamate) backbone.	Water	25-30	L1 cell adhesion molecule	Mus musculus	50-54
19808099-8	2010	These results indicate that Bi-PHGPx is a stress-inducible antioxidant enzyme that acts on phospholipid hydroperoxide and H(2)O(2).	Water	122-127	glutathione peroxidase 4	Homo sapiens	31-36
19336840-7	2009	Regarding the fluence perturbation p(cav) the simulation of the electron fluence inside the air cavity in comparison to water unambiguously reveals an in-scattering of low energy electrons, despite the fact, that the cavity is "well guarded".	Water	120-125	caveolin 2	Homo sapiens	37-40
30334671-2	2018	METHODS: Aurora kinase B (AKB) siRNA-loaded nanoparticles (AKB-LfNPs) were prepared with milk protein, lactoferrin, by water in oil emulsion method.	Water	119-124	aurora kinase B	Mus musculus	9-24
19320468-6	2009	Isomerization in water is not reversible even if only cis-1 is present in solution.	Water	17-22	suppressor of cytokine signaling 1	Homo sapiens	54-59
19381191-6	2009	Using system parameters measured with a streak camera, the model was validated for LIF imaging of acetone vapor inside a water aerosol.	Water	121-126	LIF interleukin 6 family cytokine	Homo sapiens	83-86
20043279-8	2010	This study reveals that CAP1 plays a crucial role in the regulation of ENaC-mediated alveolar sodium and water transport and in mouse lung fluid balance.	Water	105-110	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	71-75
30249222-9	2018	In addition, the ethanol and water extracts of PN significantly down-regulated HMGCR gene expression compared with those of Ya-Hom Navakot without PN (p &lt; 0.05).	Water	29-34	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	79-84
19950922-5	2010	The petroselinic acid-water partition coefficients (log K(pw), 3.37, 4.90, 5.24, and 6.28 for Nap, Phe, Pyr, and Bap, respectively) were positively correlated with the hydrophobicity of the compounds (R(2) = 0.995) and were almost the same as the lipid-normalized root partition coefficients (log K(lip)) for the corresponding compounds.	Water	22-27	prohibitin 2	Homo sapiens	113-116
19185341-5	2009	When activated with tap water, motility was maximal (80%) at 10s (earliest time measured), declining to 5% by 87 s postactivation.	Water	24-29	transporter associated with antigen processing, subunit type c	Danio rerio	20-23
19185341-8	2009	With moderate osmolalities, the rate of velocity decay was less than that with tap water activation.	Water	83-88	transporter associated with antigen processing, subunit type c	Danio rerio	79-82
30254290-4	2018	In the deeper parts of the South Kara Sea (&gt;220 m water depth) the paleo thermokarst structures lie within the present day gas hydrate stability zone, with low bottom water temperatures -1.8 oC) keeping the gas hydrate system in equilibrium.	Water	53-58	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	38-41
19754848-2	2010	This fresh water was likely emplaced during Pleistocene sea-level low stands when the shelf was exposed to meteoric recharge and by elevated recharge in areas overrun by the Laurentide ice sheet at high latitudes.	Water	11-16	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	56-59
19610106-8	2010	Vesicle acidification is therefore a prerequisite for AQP-6-mediated gating of water into synaptic vesicles.	Water	79-84	aquaporin 6	Homo sapiens	54-59
18717646-11	2009	Furthermore, the water permeability of cells expressing aquaporin-2 was strongly reduced during the apoptotic process and it occurs before DNA degradation.	Water	17-22	aquaporin 2	Homo sapiens	56-67
30133282-4	2018	The analyses using QM/MM MP2 optimization suggest that a neutral water molecule is at the active site of the enzyme-substrate (ES) complex.	Water	65-70	tryptase pseudogene 1	Homo sapiens	25-28
19626896-0	2009	[Analysis of roller ball pen water ink by capillary electrophoresis with photodiode array detector].	Water	29-34	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	25-28
19626896-1	2009	The analytical method of roller ball pen water inks was established by capillary electrophoresis with photodiode array (PDA) detector scanning in row.	Water	41-46	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	37-40
30275803-5	2018	The release dynamic of STX from the prepared hydrogels was investigated in which the diffusion through the polymer matrix, the enhancement of the water solubility of STX, the influence of the initial drug concentration, the pH of the medium, and the effect of the degree of swelling of the polymer matrix on the release dynamic was evaluated.	Water	146-151	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	23-26
19435233-7	2009	Two of the sausages (SA1 and SB1) were microbiologically stable (containing mainly lactobacilli) and had positive sensory, chemical, and physical properties (e.g., protein, 21%; water activity, 0.90; pH, between 5.3 and 5.4 on day 36) meeting all standards for commercially produced raw sausages.	Water	178-183	SH3KBP1 binding protein 1	Homo sapiens	29-32
19874479-4	2010	Here, the high-throughput assay ProteoQuant was developed to quantify the main proteobacterial phyla in tap water.	Water	108-113	filamin B	Homo sapiens	104-107
19874479-8	2010	CONCLUSIONS: Large-scale tap water screening using ProteoQuant revealed a dominance of Beta-proteobacteria and a potential interaction between Alpha- and Beta-proteobacteria.	Water	29-34	filamin B	Homo sapiens	25-28
30596177-12	2019	Conclusion: Reduced NCC expression and increased AQP2 expression would be expected to result in saliuresis and water reabsorption in TIH patients.	Water	111-116	aquaporin 2	Homo sapiens	49-53
19874479-10	2010	SIGNIFICANCE AND IMPACT OF THE STUDY: The ProteoQuant assay will potentially be important for future understanding of the ecological forces shaping the tap water microbiota.	Water	156-161	filamin B	Homo sapiens	152-155
20418627-4	2010	The experiments of photocatalytic H(2) generation showed that the catalysts (CdS)(x)/(ZnS)(1-x) with x ranging from 0.1 to 1 were able to produce hydrogen from water photolysis under visible light.	Water	160-165	CDP-diacylglycerol synthase 1	Homo sapiens	77-80
19116231-4	2009	For over 7 days of treatment with 2% DSS in the drinking water, Slc11a1 wt mice showed enhanced acute ulcerative colitis, as demonstrated by significantly greater body weight loss and reduction in colon length, as well as a marked increase in monocyte/macrophage inflammatory infiltrates and histopathology changes in the colon.	Water	57-62	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	64-71
29920829-1	2018	Water-soluble Pd12 L6 coordination cage TC-1 was synthesized by coordination-driven self-assembly of symmetrical tetrapyridyl donor L with 90  ditopic acceptor cis-[Pd(NO3 )2 (tmeda)] [tmeda=N,N,N",N"-tetramethylethane-1,2-diamine].	Water	0-5	transcobalamin 1	Homo sapiens	40-44
19254533-1	2009	Electron transfer between the water-soluble cytochrome c and the integral membrane protein cytochrome c oxidase (COX) is the terminal reaction in the respiratory chain.	Water	30-35	cytochrome c, somatic	Equus caballus	44-56
19254533-1	2009	Electron transfer between the water-soluble cytochrome c and the integral membrane protein cytochrome c oxidase (COX) is the terminal reaction in the respiratory chain.	Water	30-35	cytochrome c, somatic	Equus caballus	91-103
20418627-8	2010	The results demonstrate that the (CdS)/(ZnS) core/shell nano-particles are a novel photo-catalyst for renewable hydrogen generation from water under visible light.	Water	137-142	CDP-diacylglycerol synthase 1	Homo sapiens	34-37
30469558-4	2018	AC-9/s performance was tested by comparing total non-water absorption measured in situ by an AC-9 and an AC-s mounted on the same frame.	Water	53-58	adenylate cyclase 9	Homo sapiens	0-4
19744776-1	2009	The purpose of this work is to investigate an advanced water treatment system changes on disinfects by-products (DBPs) precursors removal efficiencies of treatment plant and associated trihalomethanes (THMs) and haloacetic acids (HAA(5)) formation and assimilable organic carbon (AOC) in reduction from raw water through finished water of Fong-shan Water Treatment Plant (FSWTP) in Kaohsiung City, Taiwan.	Water	55-60	formiminotransferase cyclodeaminase N-terminal like	Homo sapiens	339-343
19923889-10	2009	Therefore, this review will focus on H(2)O(2) modulating cell signaling via Prdxs by discussing: (1) the activity of Prdxs towards H(2)O(2); (2) sub cellular localization and availability of other peroxidases, such as catalase or glutathione peroxidases; (3) the availability of Prdxs reducing systems, such as thioredoxin and sulfiredoxin and lastly, (4) Prdx1 interacting signaling molecules.	Water	37-42	peroxiredoxin 1	Homo sapiens	356-361
19830768-1	2009	The effect of a single water molecule on the reaction mechanism of the gas-phase reaction between formic acid and the hydroxyl radical was investigated with high-level quantum mechanical calculations using DFT-B3LYP, MP2 and CCSD(T) theoretical approaches in concert with the 6-311+G(2df,2p) and aug-cc-pVTZ basis sets.	Water	23-28	tryptase pseudogene 1	Homo sapiens	217-220
19126752-4	2009	On high salt intake (1% NaCl in drinking water for 2 wk), the chromosome 16 QTL had a marked impact on SBP, as did the QTLs on chromosome 2a and 2c (18, 17, and 19 mmHg, respectively), but not the QTL on chromosome 4.	Water	41-46	spermine binding protein	Rattus norvegicus	103-106
19437762-1	2009	We report a new available strategy for fabricating 2-dimensional petal-like CdS/dodecylamine (DDA) hybrids with enhanced photoluminescence (PL) by using a method of oil/water interfacial self-assembly.	Water	169-174	CDP-diacylglycerol synthase 1	Homo sapiens	76-79
29891277-2	2018	In our previous study, we isolated a water-soluble polysaccharide (BCPS) from Bupleurum chinense and showed that it exhibits anti-inflammatory effect by antagonizing P-selectin-mediated adhesion of HL-60 cells to CHO-P cells.	Water	37-42	selectin P	Homo sapiens	166-176
18666888-3	2009	A dramatic increase in osteoclast cell volume occurs during osteoclast biogenesis and is believed to be mediated by AQP9 (aquaporin 9), a membrane protein that can rapidly transport water and other small neutral solutes across cell membranes.	Water	182-187	aquaporin 9	Mus musculus	116-120
18666888-3	2009	A dramatic increase in osteoclast cell volume occurs during osteoclast biogenesis and is believed to be mediated by AQP9 (aquaporin 9), a membrane protein that can rapidly transport water and other small neutral solutes across cell membranes.	Water	182-187	aquaporin 9	Mus musculus	122-133
19934283-2	2009	EXPERIMENTAL DESIGN: Nulliparous Her2/neu transgenic mice were treated with water or TM for 180 days and observed for tumor development during treatment and for 180 days after treatment.	Water	76-81	erb-b2 receptor tyrosine kinase 2	Mus musculus	33-41
19952119-1	2009	IPI-504, a water-soluble ansamycin analogue currently being investigated in clinical trials, is a potent inhibitor of the protein chaperone heat shock protein 90 (Hsp90).	Water	11-16	heat shock protein 90 alpha family class A member 1	Homo sapiens	163-168
19337508-7	2009	The hTERT mRNA levels were linked to water and nail As concentrations and skin hyperkeratosis.	Water	37-42	telomerase reverse transcriptase	Homo sapiens	4-9
19337508-9	2009	RESULTS: hTERT mRNA expression levels were significantly associated with As concentrations of water (p&lt;0.0001) and nails (p=0.002) and also associated with severity of skin hyperkeratosis (p&lt;0.05), adjusting for age, sex, smoking, and pesticide use.	Water	94-99	telomerase reverse transcriptase	Homo sapiens	9-14
30542585-2	2018	Herein, we present the synthesis and the binding properties of a new water-soluble near-infrared (NIR) amphiphilic squaraine dye (CAS-C1) which is capable of selective detection of parallel over non-parallel and non G4 topologies.	Water	69-74	dynein axonemal intermediate chain 7	Homo sapiens	130-136
19244492-3	2009	Soil column studies compared the effectiveness of water seals in reducing cis-1,3-dichloropropene (1,3-D) emissions from three different textured soils (loamy sand, sandy loam, and loam).	Water	50-55	suppressor of cytokine signaling 1	Homo sapiens	74-79
19190182-1	2009	We used a systems biology-based approach to investigate the basis of cell-specific expression of the water channel aquaporin-2 (AQP2) in the renal collecting duct.	Water	101-106	aquaporin 2	Mus musculus	128-132
19789273-3	2009	Here we describe a different type of totally in vitro method, DNA display, that is applicable to heterodimeric Fab fragments: in vitro compartmentalization in water-in-oil emulsions allows the linking of an oligomeric protein and its encoding DNA with multiple ORFs.	Water	159-164	FA complementation group B	Homo sapiens	111-114
19860435-5	2009	In the case of the Kemp elimination, a general base, Glu L34, carried out the proton abstraction from the isoxazole ring of 5-nitro-benzisoxazole while water molecules delivered specific stabilization at the transition state.	Water	152-157	ribosomal protein L34	Homo sapiens	57-60
19936251-4	2009	We here evaluate the effects of the Mycobacterium leprae Hsp65 in the development/progression of EAU and the autoimmune response against the eye through the induction of the endogenous disequilibrium by enhancing the entropy of the immunobiological system with the addition of homologous Hsp.	Water	97-100	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	57-62
19827762-1	2009	Mix in water, stir.	Water	7-12	Mix paired-like homeobox	Homo sapiens	0-3
19846764-4	2009	The parent antibody preorganizes Asp(H35) and Glu(L34) to abstract a proton from substrate and to orient a water molecule for leaving group stabilization, respectively.	Water	107-112	ribosomal protein L34	Homo sapiens	46-53
19846764-5	2009	Remodeling the environment of the hydrogen bond donor with a compensatory network of ordered waters, as seen in the Glu(L34) to alanine mutant, leads to an impressive 10(9)-fold rate acceleration over the nonenzymatic reaction with acetate, illustrating the utility of buried water molecules in bifunctional catalysis.	Water	93-98	ribosomal protein L34	Homo sapiens	116-123
19846791-6	2009	The structure supports earlier suggestions that the enzyme acts to lower the reduction potential of the Co(II)/Co(I) couple by elongating the bond between the cobalt and its upper axial water ligand, effectively making the cobalt 4-coordinate, and illuminates the role of Tyr-1139 in the stabilization of this 4-coordinate state.	Water	186-191	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	111-116
19463935-4	2009	We show that 1) cysteinylated beta-CN formed mainly dimers bridged by disulfide bonds; 2) the process of dimerization adds to the micellization process with temperature and is poorly reversible; 3) covalent disulfide linkage forms at the air-water interface at a lower temperature than in bulk.	Water	242-247	casein beta	Homo sapiens	30-37
19536642-4	2009	Accordingly, in the ground state, upon increasing the water proportion of the water-N,N-dimethylformamide mixtures, a hydrogen bonded complex, HBC, its hydrogen bonded proton transfer complex, PTC, a pre-cationic complex, PC, and the cation, C, are progressively formed.	Water	54-59	keratin 88, pseudogene	Homo sapiens	143-146
19536642-4	2009	Accordingly, in the ground state, upon increasing the water proportion of the water-N,N-dimethylformamide mixtures, a hydrogen bonded complex, HBC, its hydrogen bonded proton transfer complex, PTC, a pre-cationic complex, PC, and the cation, C, are progressively formed.	Water	78-83	keratin 88, pseudogene	Homo sapiens	143-146
19693000-8	2009	Furthermore, V1aR is also expressed in collecting duct cells and involved in regulating water reabsorption by affecting V2/aquaporin 2 function.	Water	88-93	aquaporin 2	Mus musculus	123-134
19780154-3	2009	Because one of the results of GM2 accumulation is cell swelling and lysosomal distension, our goal was to determine if changes in the diffusion of water is perturbed.	Water	147-152	cytochrome b5 domain containing 2	Mus musculus	30-33
20058787-3	2009	The observed increase in water permeability is connected with an increased content of the water channel"s proteins aquaporins AQP2 and AQP3 in the plasma membrane.	Water	25-30	aquaporin 2	Rattus norvegicus	126-130
20058787-3	2009	The observed increase in water permeability is connected with an increased content of the water channel"s proteins aquaporins AQP2 and AQP3 in the plasma membrane.	Water	25-30	aquaporin 3 (Gill blood group)	Rattus norvegicus	135-139
20058787-3	2009	The observed increase in water permeability is connected with an increased content of the water channel"s proteins aquaporins AQP2 and AQP3 in the plasma membrane.	Water	90-95	aquaporin 2	Rattus norvegicus	126-130
20058787-3	2009	The observed increase in water permeability is connected with an increased content of the water channel"s proteins aquaporins AQP2 and AQP3 in the plasma membrane.	Water	90-95	aquaporin 3 (Gill blood group)	Rattus norvegicus	135-139
19805165-8	2009	Cellular imaging studies using the H(2)O(2) biosensor HyPer show that siRNA-mediated eNOS knockdown leads to a marked increase in intracellular H(2)O(2) generation, which is blocked by PEG-catalase.	Water	35-40	nitric oxide synthase 3, endothelial cell	Mus musculus	85-89
19805165-11	2009	Taken together, these results establish that CaMKKbeta is critically involved in mediating the phosphorylation of AMPK promoted by H(2)O(2) in endothelial cells, and document that eNOS is an important negative regulator of AMPK phosphorylation and intracellular H(2)O(2) generation in endothelial cells.	Water	131-136	nitric oxide synthase 3, endothelial cell	Mus musculus	180-184
19605545-7	2009	Increased H2O intake enhanced differences between wild-type and pendrin null mice in I(-) balance, suggesting that H2O intake modulates pendrin abundance.	Water	10-13	solute carrier family 26, member 4	Mus musculus	64-71
19605545-7	2009	Increased H2O intake enhanced differences between wild-type and pendrin null mice in I(-) balance, suggesting that H2O intake modulates pendrin abundance.	Water	10-13	solute carrier family 26, member 4	Mus musculus	136-143
19605545-7	2009	Increased H2O intake enhanced differences between wild-type and pendrin null mice in I(-) balance, suggesting that H2O intake modulates pendrin abundance.	Water	115-118	solute carrier family 26, member 4	Mus musculus	64-71
19605545-7	2009	Increased H2O intake enhanced differences between wild-type and pendrin null mice in I(-) balance, suggesting that H2O intake modulates pendrin abundance.	Water	115-118	solute carrier family 26, member 4	Mus musculus	136-143
19605545-8	2009	Raising water intake from approximately 4 to approximately 11 ml/day increased the ratio of B cell apical plasma membrane to cytoplasm pendrin label by 75%, although circulating renin, aldosterone, and serum osmolality were unchanged.	Water	8-13	solute carrier family 26, member 4	Mus musculus	135-142
19605545-10	2009	We observed that H2O intake modulated pendrin abundance even when circulating vasopressin levels were clamped.	Water	17-20	solute carrier family 26, member 4	Mus musculus	38-45
19605545-11	2009	We conclude that H2O intake modulates pendrin abundance, although not likely through a direct, type 2 vasopressin receptor-dependent mechanism.	Water	17-20	solute carrier family 26, member 4	Mus musculus	38-45
19605545-12	2009	As water intake rises, pendrin becomes increasingly critical in the maintenance of Cl(-) and I(-) balance.	Water	3-8	solute carrier family 26, member 4	Mus musculus	23-30
19640901-3	2009	High deliveries of calcium into the IMCD would be predicted to activate CaSR, leading to reduced membrane abundance of aquaporin-2, thereby limiting water conservation and protecting against stone formation.	Water	149-154	aquaporin 2	Homo sapiens	119-130
19657734-9	2009	Nevertheless, CFTR(inh)-172 reduced basal net water output, which was reversed by lubiprostone.	Water	46-51	CF transmembrane conductance regulator	Rattus norvegicus	14-18
19585583-0	2009	p.R254Q mutation in the aquaporin-2 water channel causing dominant nephrogenic diabetes insipidus is due to a lack of arginine vasopressin-induced phosphorylation.	Water	36-41	aquaporin 2	Homo sapiens	24-35
19585583-1	2009	Vasopressin regulates human water homeostasis by re-distributing homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells, a process in which phosphorylation of AQP2 at S256 by cAMP-dependent protein kinase A (PKA) is thought to be essential.	Water	28-33	aquaporin 2	Homo sapiens	80-91
19585583-1	2009	Vasopressin regulates human water homeostasis by re-distributing homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells, a process in which phosphorylation of AQP2 at S256 by cAMP-dependent protein kinase A (PKA) is thought to be essential.	Water	28-33	aquaporin 2	Homo sapiens	93-97
19585583-1	2009	Vasopressin regulates human water homeostasis by re-distributing homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells, a process in which phosphorylation of AQP2 at S256 by cAMP-dependent protein kinase A (PKA) is thought to be essential.	Water	99-104	aquaporin 2	Homo sapiens	80-91
19585583-1	2009	Vasopressin regulates human water homeostasis by re-distributing homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells, a process in which phosphorylation of AQP2 at S256 by cAMP-dependent protein kinase A (PKA) is thought to be essential.	Water	99-104	aquaporin 2	Homo sapiens	93-97
19585583-1	2009	Vasopressin regulates human water homeostasis by re-distributing homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells, a process in which phosphorylation of AQP2 at S256 by cAMP-dependent protein kinase A (PKA) is thought to be essential.	Water	99-104	aquaporin 2	Homo sapiens	229-233
19585583-4	2009	Expressed in oocytes, AQP2-p.R254Q appeared to be a functional water channel, but was impaired in its transport to the cell surface to the same degree as AQP2-p.S256A, which mimics non-phosphorylated AQP2.	Water	63-68	aquaporin 2	Homo sapiens	22-26
19442960-1	2009	This work presents an analysis of near environment of myoglobin (Mb) in different aqueous solutions (in the presence of NaCl, sucrose, trehalose, urea, and glycerol) using the coupled water fractions measured using a quartz crystal microbalance (QCM).	Water	184-189	myoglobin	Homo sapiens	54-63
19442960-1	2009	This work presents an analysis of near environment of myoglobin (Mb) in different aqueous solutions (in the presence of NaCl, sucrose, trehalose, urea, and glycerol) using the coupled water fractions measured using a quartz crystal microbalance (QCM).	Water	184-189	myoglobin	Homo sapiens	65-67
19442960-8	2009	The dynamics of coupled water in Mb with NaCl is the fastest (around 21 ps) and is slowest in glycerol (250 ps).	Water	24-29	myoglobin	Homo sapiens	33-35
19805328-5	2009	The data indicate that significant reductions in spatial learning deficits of aged APP/PS1 mice in a Morris Water Maze can be achieved by modulating levels of Nrf2 in the brain.	Water	108-113	presenilin 1	Mus musculus	87-90
19056249-5	2009	From the concentration and surface pressure dependence on excess area and elasticity (E) it was deduced that DOPC and beta-casein form a practically immiscible monolayer at the air-water interface.	Water	181-186	casein beta	Homo sapiens	118-129
19461869-5	2009	In this work, we perform a set of molecular mechanics (MM) Poisson-Boltzmann (PB) surface area (SA) calculations on the wild type and two mutant TCR-SEC3 systems and show that the method is able to discriminate between weak and strong binders only when key explicit water molecules are included in the analysis.	Water	266-271	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	145-148
26610105-0	2009	Fully Automated Incremental Evaluation of MP2 and CCSD(T) Energies: Application to Water Clusters.	Water	83-88	tryptase pseudogene 1	Homo sapiens	42-45
19175338-1	2009	The MP2f water force field, recently developed using the adaptive force matching method, is improved significantly after the introduction of a short-range repulsion term.	Water	9-14	tryptase pseudogene 1	Homo sapiens	4-7
18829704-10	2009	However, both water influx and efflux occurred faster in Aqp7(-/-) sperm than wild-type.	Water	14-19	aquaporin 7	Mus musculus	57-61
18829704-11	2009	This faster water movement in the knockout mouse spermatozoa was explainable by an upregulation of Aqp8 expression as revealed by quantitative PCR.	Water	12-17	aquaporin 8	Mus musculus	99-103
18829704-12	2009	Therefore, the Hg(2+)-sensitive AQP8, which was localized in elongated spermatids and spermatozoa, is a likely candidate for a water channel responsible for physiological sperm volume regulation crucial to in vivo fertilization.	Water	127-132	aquaporin 8	Mus musculus	32-36
30190471-0	2018	Water chemistry reveals a significant decline in coral calcification rates in the southern Red Sea.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	95-98
19265260-2	2009	The results of DNA microarray analysis and quantitative real-time reverse transcription-polymerase chain reaction indicated the down-regulated expression of genes for glucose-6-phosphatase (G6Pase) and fatty acid synthase, and the up-regulated expression of peroxisome proliferator activated receptor alpha in the rats given green tea for 4 weeks as compared with the water-given animals.	Water	368-373	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	167-188
19265260-2	2009	The results of DNA microarray analysis and quantitative real-time reverse transcription-polymerase chain reaction indicated the down-regulated expression of genes for glucose-6-phosphatase (G6Pase) and fatty acid synthase, and the up-regulated expression of peroxisome proliferator activated receptor alpha in the rats given green tea for 4 weeks as compared with the water-given animals.	Water	368-373	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	190-196
19545538-2	2009	NMO immunoglobulin G (NMO-IgG), which recognizes astrocytic aquaporin-4 (AQP4) water channels, is a specific serum autoantibody that distinguishes NMO from MS.	Water	79-84	aquaporin 4	Rattus norvegicus	60-71
19545538-2	2009	NMO immunoglobulin G (NMO-IgG), which recognizes astrocytic aquaporin-4 (AQP4) water channels, is a specific serum autoantibody that distinguishes NMO from MS.	Water	79-84	aquaporin 4	Rattus norvegicus	73-77
19553669-5	2009	Using these methods, the solution structure of hepcidin was determined at 325 and 253 K in supercooled water.	Water	103-108	hepcidin antimicrobial peptide	Homo sapiens	47-55
19265260-2	2009	The results of DNA microarray analysis and quantitative real-time reverse transcription-polymerase chain reaction indicated the down-regulated expression of genes for glucose-6-phosphatase (G6Pase) and fatty acid synthase, and the up-regulated expression of peroxisome proliferator activated receptor alpha in the rats given green tea for 4 weeks as compared with the water-given animals.	Water	368-373	peroxisome proliferator activated receptor alpha	Rattus norvegicus	258-306
30190471-4	2018	Measured differences in total alkalinity of the Red Sea surface water indicate a 26 +- 16% decline in total CaCO3 deposition rates along the basin.	Water	64-69	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	52-55
29465422-6	2018	The face mask would have prevented the orbits from being in direct contact with salt water and therefore stopped any effects of immersion on PMVSC.	Water	85-90	ankyrin repeat and KH domain containing 1	Homo sapiens	9-13
19236263-6	2009	METHODS: The latest evidence regarding the use of geldanamycin analogues or newer water-soluble and synthetics molecules that inhibit the binding of HSP90 to client proteins was reviewed.	Water	82-87	heat shock protein 90 alpha family class A member 1	Homo sapiens	149-154
29767557-0	2018	Polycystin-1 dysfunction impairs electrolyte and water handling in a renal precystic mouse model for ADPKD.	Water	49-54	polycystin 1, transient receptor potential channel interacting	Mus musculus	0-12
19206848-4	2009	The approach is applied to plane-wave reflection-coefficient inversion of single-bounce data collected on the Malta Plateau, Mediterranean Sea, which indicate complex fine structure close to the water-sediment interface.	Water	195-200	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	139-142
19434350-2	2009	The concentrations of E1, E2, E3 and testosterone in water samples from the Johkasou were 33-500, N.D. approximately 150, N.D. approximately 6,700 and 500 ng/L, respectively.	Water	53-58	small nucleolar RNA, H/ACA box 73A	Homo sapiens	22-32
29767557-8	2018	Conversely, mRNA expression levels in kidney of genes encoding solute and water transporters in the proximal tubule ( Abcg2 and Slc34a1) and collecting duct ( Aqp2, Scnn1a, and Scnn1b) remained comparable between control and iKsp- Pkd1-/- mice, although a water reabsorption defect was observed in iKsp- Pkd1-/- mice.	Water	74-79	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	128-135
29767557-8	2018	Conversely, mRNA expression levels in kidney of genes encoding solute and water transporters in the proximal tubule ( Abcg2 and Slc34a1) and collecting duct ( Aqp2, Scnn1a, and Scnn1b) remained comparable between control and iKsp- Pkd1-/- mice, although a water reabsorption defect was observed in iKsp- Pkd1-/- mice.	Water	74-79	aquaporin 2	Mus musculus	159-163
19548648-3	2009	The betaB1-crystallin became water insoluble on the deletion of C-terminal extension and subsequent deletions of the C-terminal domain (C-terminal extension plus motifs III and IV) while it remained partially soluble on the deletion of the N-terminal domain (N-terminal arm plus motifs I and II).	Water	29-34	crystallin beta B1	Homo sapiens	4-21
18613069-1	2009	The water-catalyzed hydrolysis reaction of carbon disulfide (CS(2)) has been investigated at the levels of HF and MP2 with the basis set of 6-311++G(d,p) using the combined supramolecular/continuum models, in which up to six water molecules are involved in the hydrolysis and the effect of water bulk solvent is taken into account according to the polarizable continuum model (PCM).	Water	4-9	tryptase pseudogene 1	Homo sapiens	114-117
29767557-8	2018	Conversely, mRNA expression levels in kidney of genes encoding solute and water transporters in the proximal tubule ( Abcg2 and Slc34a1) and collecting duct ( Aqp2, Scnn1a, and Scnn1b) remained comparable between control and iKsp- Pkd1-/- mice, although a water reabsorption defect was observed in iKsp- Pkd1-/- mice.	Water	74-79	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	165-171
29767557-8	2018	Conversely, mRNA expression levels in kidney of genes encoding solute and water transporters in the proximal tubule ( Abcg2 and Slc34a1) and collecting duct ( Aqp2, Scnn1a, and Scnn1b) remained comparable between control and iKsp- Pkd1-/- mice, although a water reabsorption defect was observed in iKsp- Pkd1-/- mice.	Water	74-79	polycystin 1, transient receptor potential channel interacting	Mus musculus	231-235
29767557-8	2018	Conversely, mRNA expression levels in kidney of genes encoding solute and water transporters in the proximal tubule ( Abcg2 and Slc34a1) and collecting duct ( Aqp2, Scnn1a, and Scnn1b) remained comparable between control and iKsp- Pkd1-/- mice, although a water reabsorption defect was observed in iKsp- Pkd1-/- mice.	Water	74-79	polycystin 1, transient receptor potential channel interacting	Mus musculus	304-308
19122326-0	2009	Synthesis of a novel water-soluble cleft-type cyclophane as an N-methyl-D-aspartate receptor antagonist.	Water	21-26	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	63-92
19603758-7	2009	With the aid of ab initio calculations at the MP2/6-31+G* level, the 3300 cm(-1) bands are assigned to the bending overtone and the hydrogen-bonded OH vibration of H2O bound to CO2- via a single O-H...O linkage.	Water	164-167	tryptase pseudogene 1	Homo sapiens	46-54
29767557-9	2018	In conclusion, our data indicate that PC1 is involved in renal Mg2+, Ca2+, and water handling and its dysfunction, resulting in a systemic electrolyte imbalance characterized by low serum electrolyte concentrations.	Water	79-84	polycystin 1, transient receptor potential channel interacting	Mus musculus	38-41
29428500-0	2018	Electrostatic and hydrophobic interactions of lipid-associated alpha-synuclein: The role of a water-limited interfaces in amyloid fibrillation.	Water	94-99	synuclein alpha	Homo sapiens	63-78
19458121-1	2009	Aquaporin-2 (AQP2) is a water channel responsible for the final water reabsorption in renal collecting ducts.	Water	24-29	aquaporin 2	Homo sapiens	0-11
19458121-1	2009	Aquaporin-2 (AQP2) is a water channel responsible for the final water reabsorption in renal collecting ducts.	Water	24-29	aquaporin 2	Homo sapiens	13-17
19458121-1	2009	Aquaporin-2 (AQP2) is a water channel responsible for the final water reabsorption in renal collecting ducts.	Water	64-69	aquaporin 2	Homo sapiens	0-11
19458121-1	2009	Aquaporin-2 (AQP2) is a water channel responsible for the final water reabsorption in renal collecting ducts.	Water	64-69	aquaporin 2	Homo sapiens	13-17
19458121-5	2009	AQP2-wt induces a major increase in water permeability (P(f) = 47.4 +/- 12.2 x 10(-4) cm/s) whereas D150E displays intermediate P(f) values (P(f) = 12.5 +/- 3.0 x 10(-4) cm/s) and G196D presents no specific water flux, similar to controls (P(f) = 2.1 +/- 0.8 x 10(-4) cm/s and 2.2 +/- 0.7 x 10(-4) cm/s, respectively).	Water	36-41	aquaporin 2	Homo sapiens	0-4
19281766-10	2009	In the absence of protein synthesis, the observed subcellular redistribution of AQP0 in DF and subsequent cleavage of AQP0 in MF are suggestive of a switch in the function of AQP0 from a water channel to a junctional protein.	Water	187-192	major intrinsic protein of lens fiber	Rattus norvegicus	80-84
19281766-10	2009	In the absence of protein synthesis, the observed subcellular redistribution of AQP0 in DF and subsequent cleavage of AQP0 in MF are suggestive of a switch in the function of AQP0 from a water channel to a junctional protein.	Water	187-192	major intrinsic protein of lens fiber	Rattus norvegicus	118-122
19281766-10	2009	In the absence of protein synthesis, the observed subcellular redistribution of AQP0 in DF and subsequent cleavage of AQP0 in MF are suggestive of a switch in the function of AQP0 from a water channel to a junctional protein.	Water	187-192	major intrinsic protein of lens fiber	Rattus norvegicus	118-122
19096775-1	2009	Principal cells lining renal collecting ducts control the fine-tuning of body water homeostasis by regulating water reabsorption through the water channels aquaporin-2 (AQP2), aquaporin-3 (AQP3), and aquaporin-4 (AQP4).	Water	78-83	aquaporin 2	Homo sapiens	156-167
19458121-5	2009	AQP2-wt induces a major increase in water permeability (P(f) = 47.4 +/- 12.2 x 10(-4) cm/s) whereas D150E displays intermediate P(f) values (P(f) = 12.5 +/- 3.0 x 10(-4) cm/s) and G196D presents no specific water flux, similar to controls (P(f) = 2.1 +/- 0.8 x 10(-4) cm/s and 2.2 +/- 0.7 x 10(-4) cm/s, respectively).	Water	207-212	aquaporin 2	Homo sapiens	0-4
19458121-7	2009	When coinjecting AQP2-wt with mutants, no (AQP2-wt + D150E) or partial (AQP2-wt + G196D) reduction of water flux were observed compared with AQP2-wt alone, whereas complete loss of function was found when both mutants were coinjected.	Water	102-107	aquaporin 2	Homo sapiens	17-21
19096775-1	2009	Principal cells lining renal collecting ducts control the fine-tuning of body water homeostasis by regulating water reabsorption through the water channels aquaporin-2 (AQP2), aquaporin-3 (AQP3), and aquaporin-4 (AQP4).	Water	110-115	aquaporin 2	Homo sapiens	156-167
29428500-4	2018	These contradicting actions arise from the limited water content near lipid-water interfaces that controls alphaSyn electrostatic and hydrophobic interactions.	Water	51-56	synuclein alpha	Homo sapiens	107-115
19096775-1	2009	Principal cells lining renal collecting ducts control the fine-tuning of body water homeostasis by regulating water reabsorption through the water channels aquaporin-2 (AQP2), aquaporin-3 (AQP3), and aquaporin-4 (AQP4).	Water	110-115	aquaporin 2	Homo sapiens	169-173
19096775-1	2009	Principal cells lining renal collecting ducts control the fine-tuning of body water homeostasis by regulating water reabsorption through the water channels aquaporin-2 (AQP2), aquaporin-3 (AQP3), and aquaporin-4 (AQP4).	Water	110-115	aquaporin 3 (Gill blood group)	Homo sapiens	189-193
29428500-4	2018	These contradicting actions arise from the limited water content near lipid-water interfaces that controls alphaSyn electrostatic and hydrophobic interactions.	Water	76-81	synuclein alpha	Homo sapiens	107-115
19096775-4	2009	This permits water entry into the cells and water exit through AQP3 and AQP4.	Water	13-18	aquaporin 3 (Gill blood group)	Homo sapiens	63-67
19096775-4	2009	This permits water entry into the cells and water exit through AQP3 and AQP4.	Water	44-49	aquaporin 3 (Gill blood group)	Homo sapiens	63-67
29428500-5	2018	Thus, understanding the molecular interactions between alphaSyn and lipid membranes in the presence of water molecules is critical in elucidating the pivotal role of lipid-associated alphaSyn in amyloid self-assembly.	Water	103-108	synuclein alpha	Homo sapiens	55-63
19497742-1	2009	MCH1R inhibitors with the quinoline moiety having the aromatic amine and aliphatic amine chain were selected, and then the effect of substituents of the quinoline ring on the ionic interaction were studied by calculating pK(a) values for these amines at the B3LYP/6-311++G(d,p)//B3LYP/6-31+G(d) level in the gas phase and in water.	Water	325-330	melanin concentrating hormone receptor 1	Homo sapiens	0-5
19096777-6	2009	Water homeostasis of the inner ear is regulated in part via the arginine vasopressin-AQP2 system in the same fashion as in the kidney, and endolymphatic hydrops, a morphological characteristic of Meniere"s disease, is thought to be caused by mal-regulation of this system.	Water	0-5	aquaporin 2	Homo sapiens	85-89
29428500-7	2018	Moreover, membrane amyloid self-assembly of alphaSyn will be further discussed with regards to the structural dynamics of lipid-associated alphaSyn and water molecules near the interface.	Water	152-157	synuclein alpha	Homo sapiens	44-52
19096779-2	2009	Some are directly involved in water transport, such as AQP5, which is involved in sweat secretion.	Water	30-35	aquaporin 5	Homo sapiens	55-59
19096779-5	2009	Both water and glycerol transport by AQP3 appear to play an important role in hydration of mammalian skin epidermis.	Water	5-10	aquaporin 3 (Gill blood group)	Homo sapiens	37-41
30369007-6	2018	We demonstrate that Inca colonies, from Camarones 9 site, were significantly affected by chemical contaminants in their food and water.	Water	129-134	caspase recruitment domain family member 17	Homo sapiens	20-24
19096780-1	2009	The aquaporin-7 (AQP7) water channel is known to be a member of the aquaglyceroporins, which allow the rapid transport of glycerol and water.	Water	23-28	aquaporin 7	Mus musculus	4-15
19096780-1	2009	The aquaporin-7 (AQP7) water channel is known to be a member of the aquaglyceroporins, which allow the rapid transport of glycerol and water.	Water	23-28	aquaporin 7	Mus musculus	17-21
19096780-1	2009	The aquaporin-7 (AQP7) water channel is known to be a member of the aquaglyceroporins, which allow the rapid transport of glycerol and water.	Water	135-140	aquaporin 7	Mus musculus	4-15
19096780-1	2009	The aquaporin-7 (AQP7) water channel is known to be a member of the aquaglyceroporins, which allow the rapid transport of glycerol and water.	Water	135-140	aquaporin 7	Mus musculus	17-21
19827488-0	2009	Assessment of MS-2 phage and salt tracers to characterize axial dispersion in water distribution systems.	Water	78-83	MS2	Homo sapiens	14-18
30010841-5	2018	qnrA, intI1 and sul1 genes in surface water were significantly higher than erm(B) and tet(W); however, no difference was present in sediment samples.	Water	38-43	IntI1	Escherichia coli	6-11
19569709-9	2009	The energetics for the (*)OH addition have shown dependence on the site of activation with (HTpe-OH)(*) adducts at C2 and C4 and the (Tpe-OH)(*) adduct at C2 being more thermodynamically stable and the water elimination to give the indoloxyl radical proceeds fast from (HTpe-OH)(*) adduct at C4 due to favorable geometry.	Water	202-207	complement C2	Homo sapiens	115-124
19096781-3	2009	AQP3, 7, 9, and 10 are subcategorized as aquaglyceroporins which permeabilize glycerol as well as water.	Water	98-103	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
19291577-2	2009	The inhibitory effect of RBE on potato polyphenol oxidase (PPO) activity and its total phenolic compound content were highest at an extraction ratio of 1:3 (rice bran:water, w/v), extraction time of 30 min, and extraction temperature of 40 degrees C. RBE showed the most inhibitory effect on PPO activity at pH 6.5.	Water	167-172	catechol oxidase B, chloroplastic	Solanum tuberosum	32-57
29960183-0	2018	Stomata regulation by tissue-specific expression of the Citrus sinensis MYB61 transcription factor improves water-use efficiency in Arabidopsis.	Water	108-113	myb domain protein 61	Arabidopsis thaliana	72-77
20374732-7	2009	Mutations have been identified in the aquaporin-2 gene (AQP2, OMIM 107777)(1), which is located in chromosome region 12q13 and codes for the vasopressin-sensitive water channel.	Water	163-168	aquaporin 2	Homo sapiens	38-49
20374732-7	2009	Mutations have been identified in the aquaporin-2 gene (AQP2, OMIM 107777)(1), which is located in chromosome region 12q13 and codes for the vasopressin-sensitive water channel.	Water	163-168	aquaporin 2	Homo sapiens	56-60
19842489-4	2009	Complexes of C(NH3)2, C(PH3)2, C[P(CH3)3]2, CF2, CCl2, and imidazol-2-ylidene with such proton donors as H2O, HCF3, HCN and HCCH have been analyzed by means of high-level quantum chemical methods.	Water	105-108	C-C motif chemokine ligand 2	Homo sapiens	49-53
19537774-1	2009	In this work we report the results of a broadband dielectric spectroscopy study on the dynamics of a globular protein, myoglobin, in confined geometry, i.e. encapsulated in a porous silica matrix, at low hydration levels, where about only one or two water layers surround the proteins.	Water	250-255	myoglobin	Homo sapiens	119-128
19244407-2	2009	The antidiuretic hormone arginine vasopressin (AVP) increases collecting duct water permeability by enhancing aquaporin-2 (AQP2) water channel insertion in the apical membrane of principal cells, allowing water to passively flow along the osmotic gradient from the tubule lumen to the interstitium.	Water	129-134	aquaporin 2	Homo sapiens	110-121
19022253-6	2008	In conclusion, these results suggest a function for AtTIP1;3 and AtTIP5;1 as specific water and urea channels in Arabidopsis pollen.	Water	86-91	tonoplast intrinsic protein 1;3	Arabidopsis thaliana	52-60
29853044-1	2018	An adsorptive stripping voltammetric method for the determination of As(III) and Astotal in water samples using a carrageenan modified carbon paste electrode is presented for the first time (CAR-CPE).	Water	92-97	carboxypeptidase E	Homo sapiens	195-198
29883817-8	2018	Treatment with a high dose of recombinant human MANF (20 mug/20 muL) significantly increased the modified Garcia score, and reduced brain water content as well as cerebral edema volume on magnetic resonance imaging.	Water	138-143	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	48-52
18991420-7	2008	Increased film wettability, as the water contact angle of films increased from 420 to 550, resulted in a decreased total number of immobilized CALB molecules.	Water	35-40	calbindin 1	Homo sapiens	143-147
18991420-8	2008	With further increases in the water contact angle of films from 55 degrees to 63 degrees, there was an increased tendency of CALB molecules to form aggregates on surfaces.	Water	30-35	calbindin 1	Homo sapiens	125-129
19244407-2	2009	The antidiuretic hormone arginine vasopressin (AVP) increases collecting duct water permeability by enhancing aquaporin-2 (AQP2) water channel insertion in the apical membrane of principal cells, allowing water to passively flow along the osmotic gradient from the tubule lumen to the interstitium.	Water	129-134	aquaporin 2	Homo sapiens	123-127
19244407-2	2009	The antidiuretic hormone arginine vasopressin (AVP) increases collecting duct water permeability by enhancing aquaporin-2 (AQP2) water channel insertion in the apical membrane of principal cells, allowing water to passively flow along the osmotic gradient from the tubule lumen to the interstitium.	Water	129-134	aquaporin 2	Homo sapiens	110-121
19244407-2	2009	The antidiuretic hormone arginine vasopressin (AVP) increases collecting duct water permeability by enhancing aquaporin-2 (AQP2) water channel insertion in the apical membrane of principal cells, allowing water to passively flow along the osmotic gradient from the tubule lumen to the interstitium.	Water	129-134	aquaporin 2	Homo sapiens	123-127
19244407-9	2009	These examples illustrate how cross talk between various stimuli regulates AQP2 abundance in collecting duct principal cells and consequently contributes to maintenance of body water homeostasis.	Water	177-182	aquaporin 2	Homo sapiens	75-79
19020152-3	2008	Aquaporin-4 (AQP4) plays an important role in maintaining brain water homeostasis under various neurological insults.	Water	64-69	aquaporin 4	Rattus norvegicus	0-11
30120575-7	2018	Under optimal working conditions, the detection limit (3 times of the standard deviation) is 0.03 ng mL-1 in the water samples.	Water	113-118	L1 cell adhesion molecule	Mus musculus	101-105
19020152-3	2008	Aquaporin-4 (AQP4) plays an important role in maintaining brain water homeostasis under various neurological insults.	Water	64-69	aquaporin 4	Rattus norvegicus	13-17
18691264-3	2008	A screen of natural accessions of Arabidopsis thaliana revealed Tsu-1 and Kas-1 to be opposite extremes for water-use efficiency and climate at collection sites for these accessions differs greatly.	Water	108-113	3-ketoacyl-acyl carrier protein synthase I	Arabidopsis thaliana	74-79
18691264-8	2008	Analysis of this reciprocal cross showed a large effect of cytoplasmic background, as well as two QTL for delta(13)C. The Kas-1 x Tsu-1 mapping population provides a powerful new resource for mapping QTL underlying natural variation and for dissecting the genetic basis of water-use efficiency differences.	Water	273-278	3-ketoacyl-acyl carrier protein synthase I	Arabidopsis thaliana	122-127
19777134-1	2009	A two step synthesis of 2-alkynyl-4-arylquinolines has been accomplished via Pd/C-mediated regioselective C-2 alkynylation of 2,4-dichloroquinoline in water followed by Suzuki coupling at C-4 of the resulting 4-chloro derivative.	Water	151-156	complement C2	Homo sapiens	106-109
19777134-1	2009	A two step synthesis of 2-alkynyl-4-arylquinolines has been accomplished via Pd/C-mediated regioselective C-2 alkynylation of 2,4-dichloroquinoline in water followed by Suzuki coupling at C-4 of the resulting 4-chloro derivative.	Water	151-156	complement C4A (Rodgers blood group)	Homo sapiens	188-191
19590705-8	2009	Elevation of HO activity via induction of HO-1 expression within neighboring cells may provide protection from cytotoxicity caused by inflammatory oxidants like H(2)O(2).	Water	161-166	heme oxygenase 1	Homo sapiens	42-46
29758891-4	2018	The express-method of subcritical water extraction was used for BaP extraction from samples.	Water	34-39	prohibitin 2	Homo sapiens	64-67
19804703-1	2009	Apelin is a recently identified peptide which plays an important role in cardiovascular function and in water metabolism.	Water	104-109	apelin	Danio rerio	0-6
30112698-5	2018	The results indicate that the electrospun CMCS/PEO membrane could effectively avoid water loss in strawberries and has a remarkable effect to prolong strawberries" shelf life due to its breathability and antibacterial activity.	Water	84-89	G protein signaling modulator 2	Homo sapiens	42-46
19548727-7	2009	The interaction energy for water clusters extrapolated to an infinite number of carbon atoms amounts to -13.0 and -15.8 kJ/mol with SCS-MP2 and DFT-D, respectively.	Water	27-32	tryptase pseudogene 1	Homo sapiens	136-139
19548727-8	2009	Hydrogen sulfide interacts more strongly than water with the hydrocarbons studied, leading to a limiting value of -21.7 kJ/mol with the SCS-MP2 method.	Water	46-51	tryptase pseudogene 1	Homo sapiens	140-143
19445502-2	2009	Ultrasensitive SERS detection of p-nitrophenol can be achieved when oxidation of surface-immobilized Ag nanoparticles is inhibited by replacing the oxygen dissolved in water with argon gas.	Water	168-173	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	15-19
18832438-7	2008	In the brain of VDR-null mice, expression of c-Fos, which is known to associate with increased water intake, was increased in the hypothalamic paraventricular nucleus and the subfornical organ.	Water	95-100	FBJ osteosarcoma oncogene	Mus musculus	45-50
18980364-1	2008	We report herein a computational study of proton transfer reactions between dithiophosphinic acids (HAs) and water clusters using B3LYP and MP2 methods.	Water	109-114	tryptase pseudogene 1	Homo sapiens	140-143
29944367-6	2018	At their dissociation thresholds, the anharmonic to harmonic density of states ratio, rhoanh( E)/rhoh( E), is ~2, ~ 3, and ~260 for I-(H2O), (H2O)2, and I-(H2O)2, respectively.	Water	135-138	ras homolog family member H	Homo sapiens	97-101
19040709-1	2009	AIM: The study was undertaken to determine whether ageing affects kidney expression of the aquaporin-2 (AQP2) water channel in glucocorticoid-deficient rats.	Water	110-115	aquaporin 2	Rattus norvegicus	91-102
19040709-1	2009	AIM: The study was undertaken to determine whether ageing affects kidney expression of the aquaporin-2 (AQP2) water channel in glucocorticoid-deficient rats.	Water	110-115	aquaporin 2	Rattus norvegicus	104-108
19040709-7	2009	AQP2 expression levels were significantly augmented in the glucocorticoid-deficient rats compared with the controls under both basal and water-loaded conditions.	Water	137-142	aquaporin 2	Rattus norvegicus	0-4
18844346-2	2008	The reconstituted ferric myoglobin was found to be five-coordinate without iron-bound water molecules.	Water	86-91	myoglobin	Homo sapiens	25-34
29944367-6	2018	At their dissociation thresholds, the anharmonic to harmonic density of states ratio, rhoanh( E)/rhoh( E), is ~2, ~ 3, and ~260 for I-(H2O), (H2O)2, and I-(H2O)2, respectively.	Water	142-145	ras homolog family member H	Homo sapiens	97-101
29944367-6	2018	At their dissociation thresholds, the anharmonic to harmonic density of states ratio, rhoanh( E)/rhoh( E), is ~2, ~ 3, and ~260 for I-(H2O), (H2O)2, and I-(H2O)2, respectively.	Water	142-145	ras homolog family member H	Homo sapiens	97-101
19010883-5	2008	The ability of arsenite to impede p53 activation is further demonstrated by a significantly blunted p53-dependent tissue response to 5FU treatment when mice were fed with arsenite-containing water.	Water	191-196	transformation related protein 53, pseudogene	Mus musculus	34-37
30123127-5	2018	Histidine residue acts as general base thus leading to attacking water molecule activation and subsequent SN2 inline hydrolysis resulting in BChE reactivation.	Water	65-70	butyrylcholinesterase	Homo sapiens	141-145
19010883-5	2008	The ability of arsenite to impede p53 activation is further demonstrated by a significantly blunted p53-dependent tissue response to 5FU treatment when mice were fed with arsenite-containing water.	Water	191-196	transformation related protein 53, pseudogene	Mus musculus	100-103
19297454-1	2009	Aquaporin-4 (AQP4) is a basolateral water channel in collecting duct principal cells and assembles into orthogonal array particles (OAPs), the size of which appears to depend on relative expression levels of AQP4 splice variants.	Water	36-41	aquaporin 4	Rattus norvegicus	0-11
19297454-1	2009	Aquaporin-4 (AQP4) is a basolateral water channel in collecting duct principal cells and assembles into orthogonal array particles (OAPs), the size of which appears to depend on relative expression levels of AQP4 splice variants.	Water	36-41	aquaporin 4	Rattus norvegicus	13-17
22063575-2	2008	Gelling of porcine myosin involved a change in myosin conformation with protein-protein and protein-water interactions.	Water	100-105	myosin heavy chain 14	Homo sapiens	19-25
30028452-3	2018	Benefiting from the strong coupling and synergistic effect between CoP QDs and highly conductive S,N-codoped carbon, well-structured porosity and high specific surface area, the resulting CoP@SNC exhibits excellent activities for oxygen evolution reaction (OER), hydrogen evolution reaction (HER), and oxygen reduction reaction (ORR), making it a trifunctional electro-catalyst for overall water splitting and rechargeable Zn-air batteries.	Water	390-395	caspase recruitment domain family member 16	Homo sapiens	188-191
18774785-1	2008	The binary complexes of water with styrene and fluorostyrene were investigated using LIF and FDIR spectroscopic techniques.	Water	24-29	LIF interleukin 6 family cytokine	Homo sapiens	85-88
19269167-2	2009	A low water activity played a significant role in the induction of Lip1, as evidenced by the increased expression level (20-46 microg/g dry cell) along with the decrease of water activity (0.927-0.969).	Water	6-11	PTPRF interacting protein alpha 1	Homo sapiens	67-71
30028452-4	2018	When CoP@SNC is used for overall water splitting, a cell voltage as low as 1.64 V is required to reach the current density of 10 mA cm-2; the obtained rechargeable Zn-air battery with CoP@SNC as the air cathode exhibits a high open-circuit voltage of 1.45 V, a very low discharge-charge voltage gap (0.83 V at 10 mA cm-2), and a long cycle life (up to 180 cycles).	Water	33-38	caspase recruitment domain family member 16	Homo sapiens	5-8
19269167-2	2009	A low water activity played a significant role in the induction of Lip1, as evidenced by the increased expression level (20-46 microg/g dry cell) along with the decrease of water activity (0.927-0.969).	Water	173-178	PTPRF interacting protein alpha 1	Homo sapiens	67-71
30028452-4	2018	When CoP@SNC is used for overall water splitting, a cell voltage as low as 1.64 V is required to reach the current density of 10 mA cm-2; the obtained rechargeable Zn-air battery with CoP@SNC as the air cathode exhibits a high open-circuit voltage of 1.45 V, a very low discharge-charge voltage gap (0.83 V at 10 mA cm-2), and a long cycle life (up to 180 cycles).	Water	33-38	caspase recruitment domain family member 16	Homo sapiens	184-187
29577247-2	2018	OBJECTIVES: We investigated whether restoration of skin pH through topical application of a water-in-oil emulsion with pH 4 improved the barrier homeostasis in aged skin, and compared the effects with an identical galenic formulation with pH 5 8.	Water	92-97	prolyl 4-hydroxylase, transmembrane	Homo sapiens	119-123
18766438-3	2009	Arginine vasopressin (AVP) via the V(1A) receptor vasoconstricts and via the V(2) receptor promotes water reabsorption in the renal collecting duct by inserting aquaporin-2 water channels into the luminal membrane.	Water	100-105	aquaporin 2	Homo sapiens	161-172
18766438-3	2009	Arginine vasopressin (AVP) via the V(1A) receptor vasoconstricts and via the V(2) receptor promotes water reabsorption in the renal collecting duct by inserting aquaporin-2 water channels into the luminal membrane.	Water	173-178	aquaporin 2	Homo sapiens	161-172
18763814-7	2008	Similarly, the hydrodynamic damping of the tip increases and then decreases as the tip approaches the solid/water interface, with the magnitude depending on the species present in the solution.	Water	108-113	TOR signaling pathway regulator	Homo sapiens	43-46
18763814-7	2008	Similarly, the hydrodynamic damping of the tip increases and then decreases as the tip approaches the solid/water interface, with the magnitude depending on the species present in the solution.	Water	108-113	TOR signaling pathway regulator	Homo sapiens	83-86
18853286-3	2008	Aquaporin5 plays a critical role in the maintenance of normal lung water homeostasis.	Water	67-72	aquaporin 5	Homo sapiens	0-10
29577247-8	2018	CONCLUSIONS: Exogenous acidification through topical application of a water-in-oil emulsion with pH 4 leads to improvement of the skin barrier function and maintenance of the barrier homeostasis in aged skin.	Water	70-75	prolyl 4-hydroxylase, transmembrane	Homo sapiens	97-101
19472194-4	2009	Plasma membrane osmotic water permeability analysis, measured by YFP-based fluorescence quenching method and Xenopus oocyte expression assays, demonstrated that NPA1 or NPA2 deletion significantly reduced human AQP1 water permeability nearly 50% compared to wild-type AQP1, while NPA1,2 double deletion had little effect on human AQP1 water permeability.	Water	24-29	URB2 ribosome biogenesis homolog	Homo sapiens	169-173
29396622-1	2018	BACKGROUND: AQP2 water channel is critical for urinary concentration in the kidney.	Water	17-22	aquaporin 2	Homo sapiens	12-16
19472194-4	2009	Plasma membrane osmotic water permeability analysis, measured by YFP-based fluorescence quenching method and Xenopus oocyte expression assays, demonstrated that NPA1 or NPA2 deletion significantly reduced human AQP1 water permeability nearly 50% compared to wild-type AQP1, while NPA1,2 double deletion had little effect on human AQP1 water permeability.	Water	216-221	URB2 ribosome biogenesis homolog	Homo sapiens	169-173
19472194-4	2009	Plasma membrane osmotic water permeability analysis, measured by YFP-based fluorescence quenching method and Xenopus oocyte expression assays, demonstrated that NPA1 or NPA2 deletion significantly reduced human AQP1 water permeability nearly 50% compared to wild-type AQP1, while NPA1,2 double deletion had little effect on human AQP1 water permeability.	Water	216-221	URB2 ribosome biogenesis homolog	Homo sapiens	169-173
19436108-7	2009	In vivo, water restriction of rats or mice led to increased urine osmolality, increased Sgk1 expression, increased expression of the type A natriuretic peptide receptor (NPR-A), and dehydration natriuresis.	Water	9-14	serum/glucocorticoid regulated kinase 1	Mus musculus	88-92
19007081-2	2008	METHODS: (1) QDs were chemically modified with Smad2 proteins to prepare water soluble QDs-Smad2 monoclonal antibody fluorescent probes which were purified after preparation.	Water	73-78	SMAD family member 2	Rattus norvegicus	47-52
19007081-2	2008	METHODS: (1) QDs were chemically modified with Smad2 proteins to prepare water soluble QDs-Smad2 monoclonal antibody fluorescent probes which were purified after preparation.	Water	73-78	SMAD family member 2	Rattus norvegicus	91-96
18621412-7	2008	Over large catchments, half-life times were important in terms of global loss from the agricultural lands to wetlands whereas over small catchments, soil organic carbon/water distribution coefficient (Koc) was an important term for pesticides losses to water system since half-life times were not limiting factors.	Water	169-174	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	201-204
29396622-5	2018	Osmotic water permeability (Pf) of the AQP2-rich EVs was measured by a stopped-flow method monitoring scattered light intensity in response to outwardly directed osmotic gradient.	Water	8-13	aquaporin 2	Homo sapiens	39-43
29655889-6	2018	TLP-1 from water elution possessed of higher reducing power and scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, superoxide radical and hydroxyl radical than TLP-2 eluted by 0.1M of NaCl.	Water	11-16	cysteine rich protein 3	Homo sapiens	0-3
18766219-8	2008	Attempts to transform the Si-H bonds of some TTF(SiMe2H)n (n = 1, 2) into Si-O functions using stoichiometric amounts of water in the presence of tris(dibenzylideneacetone)dipalladium(0) were unsuccessful.	Water	121-126	ras homolog family member H	Homo sapiens	45-48
30140924-8	2018	The ability of mutant SLC4A11-expressing cells to mediate water flux (SLC4A11 mediates water flux across the corneal endothelial cell basolateral membrane as part of the endothelial water pump) was measured upon treatment with ophthalmic NSAIDs.	Water	58-63	solute carrier family 4 member 11	Homo sapiens	22-29
18597765-0	2008	Syringe pump-assisted synthesis of water-soluble cubic structure Ag2Se nanocrystals by a cation-exchange reaction.	Water	35-40	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	65-68
18760506-6	2009	Moreover, UBB(+1) transgenic mice show a deficit in contextual memory in both water maze and fear conditioning paradigms.	Water	78-83	ubiquitin 1	Mus musculus	10-16
30140924-8	2018	The ability of mutant SLC4A11-expressing cells to mediate water flux (SLC4A11 mediates water flux across the corneal endothelial cell basolateral membrane as part of the endothelial water pump) was measured upon treatment with ophthalmic NSAIDs.	Water	58-63	solute carrier family 4 member 11	Homo sapiens	70-77
19368400-4	2009	Our analysis of several features of MP2/aug-cc-pVDZ-optimized stable clusters with different number and arrangement of water molecules shows that two different kinds of halogen-water coordination patterns are involved in the stability and properties found for these systems: halogen bonds (X-X...O) and halogen-hydrogen interactions, (X-X...H-O-H).	Water	119-124	tryptase pseudogene 1	Homo sapiens	36-39
19368400-4	2009	Our analysis of several features of MP2/aug-cc-pVDZ-optimized stable clusters with different number and arrangement of water molecules shows that two different kinds of halogen-water coordination patterns are involved in the stability and properties found for these systems: halogen bonds (X-X...O) and halogen-hydrogen interactions, (X-X...H-O-H).	Water	177-182	tryptase pseudogene 1	Homo sapiens	36-39
30140924-8	2018	The ability of mutant SLC4A11-expressing cells to mediate water flux (SLC4A11 mediates water flux across the corneal endothelial cell basolateral membrane as part of the endothelial water pump) was measured upon treatment with ophthalmic NSAIDs.	Water	87-92	solute carrier family 4 member 11	Homo sapiens	70-77
30140924-12	2018	Diclofenac restored mutant SLC4A11 water flux activity to the level of wild-type SLC4A11 in some cases.	Water	35-40	solute carrier family 4 member 11	Homo sapiens	27-34
29492757-8	2018	Marked water diffusion abnormality as demonstrated by hyperintense DWI in vulnerable regions of the brain was detected after CA/CPR, with the most prominent hyperintense DWI observed in the hippocampal CA1 region at 72 h. Consistently, histological examination revealed neuronal swelling, dendritic injury, and activation of astrocytes and microglia in the hippocampal CA1 region in vehicle-treated rats.	Water	7-12	carbonic anhydrase 1	Rattus norvegicus	202-205
19374378-0	2009	Free energies and entropies of water molecules at the inhibitor-protein interface of DNA gyrase.	Water	31-36	DNA topoisomerase II alpha	Homo sapiens	85-95
19374378-1	2009	Complexes of the antibiotics novobiocin and clorobiocin with DNA gyrase are illustrative of the importance of bound water to binding thermodynamics.	Water	116-121	DNA topoisomerase II alpha	Homo sapiens	61-71
29492757-8	2018	Marked water diffusion abnormality as demonstrated by hyperintense DWI in vulnerable regions of the brain was detected after CA/CPR, with the most prominent hyperintense DWI observed in the hippocampal CA1 region at 72 h. Consistently, histological examination revealed neuronal swelling, dendritic injury, and activation of astrocytes and microglia in the hippocampal CA1 region in vehicle-treated rats.	Water	7-12	carbonic anhydrase 1	Rattus norvegicus	369-372
29931732-0	2018	A Water Dissolvable Electrolyte with an Ionic Liquid for Eco-Friendly Electronics.	Water	2-7	ciliogenesis associated kinase 1	Homo sapiens	57-60
19538313-0	2009	The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transport.	Water	87-92	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	16-21
29901984-4	2018	Using this approach, we predicted that the hydride transfer reaction catalyzed by the enzyme dihydrofolate reductase (DHFR) from Escherichia coli in aqueous mixtures of isopropanol (IPA) with water will decrease by ~3 fold at 20% (v/v) IPA concentration.	Water	192-197	Dihydrofolate reductase	Escherichia coli	93-116
18508286-2	2009	Heterogeneous nuclear ribonucleoprotein C (hnRNP-C), a nuclear pre-mRNA binding protein that plays roles in vertebrate cell proliferation and differentiation, has been identified as a component of a vascular cell signaling pathway activated by low physiologic levels of H(2)O(2).	Water	270-275	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	0-41
18508286-2	2009	Heterogeneous nuclear ribonucleoprotein C (hnRNP-C), a nuclear pre-mRNA binding protein that plays roles in vertebrate cell proliferation and differentiation, has been identified as a component of a vascular cell signaling pathway activated by low physiologic levels of H(2)O(2).	Water	270-275	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	43-50
29901984-4	2018	Using this approach, we predicted that the hydride transfer reaction catalyzed by the enzyme dihydrofolate reductase (DHFR) from Escherichia coli in aqueous mixtures of isopropanol (IPA) with water will decrease by ~3 fold at 20% (v/v) IPA concentration.	Water	192-197	Dihydrofolate reductase	Escherichia coli	118-122
19650486-1	2009	Sea water samples were collected in the East China Sea in March and April, 2005, and three-dimensional fluorescence of dissolved organic matter was measured by fluorescence excitation-emission matrix spectroscopy.	Water	4-9	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
19372483-4	2009	METHODS: Twenty to 40 microg of recombinant HBD-3 were labeled with (99m)Tc(+) hexa-coordinated with 3 molecules of CO and H(2)O and separated by a column from free (99m)Tc.	Water	123-128	defensin beta 103B	Homo sapiens	44-49
19252888-0	2009	Water input requirements of the rapidly shrinking Dead Sea.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	55-58
19252888-1	2009	The deepest point on Earth, the Dead Sea level, has been dropping alarmingly since 1978 by 0.7 m/a on average due to the accelerating water consumption in the Jordan catchment and stood in 2008 at 420 m below sea level.	Water	134-139	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	37-40
19252888-2	2009	In this study, a terrain model of the surface area and water volume of the Dead Sea was developed from the Shuttle Radar Topography Mission data using ArcGIS.	Water	55-60	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	80-83
19639693-3	2009	The mineral water promoted realization of trophic effects of gastrin and insulin in animals with peptic ulcer the size of which significantly decreased.	Water	12-17	gastrin	Homo sapiens	61-68
19230825-9	2009	Taken together, endothelial ET-1 over-expression and ETA receptor activation contributes to the increased oxidative stress, water accumulation and BBB breakdown after transient MCAO leading to more severe neurological deficit and increased infarct.	Water	124-129	endothelin 1	Mus musculus	28-32
19354314-1	2009	MP2 and CCSD(T) complete basis set (CBS) limit relative electronic energies (DeltaE(e)) have been determined for eight low-lying structures of the water hexamer by combining explicitly correlated MP2-R12 computations with higher-order correlation corrections from CCSD(T) calculations.	Water	147-152	tryptase pseudogene 1	Homo sapiens	196-199
19146830-4	2009	Incubation of MDCK cells in hypertonic NaCl medium (500 mOsm/kg H2O) caused fully translocation of TonEBP/NFAT5 from cytoplasm to nucleoplasm and significantly increased COX2 mRNA, protein and activity levels.	Water	64-67	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	170-174
19714824-4	2009	We conclude that thin water layers can be observed using SANS; however, the layers are thin and correspond to essentially the hydration of the particle surfaces.	Water	22-27	USH1 protein network component sans	Homo sapiens	57-61
19714887-1	2009	We have used SANS techniques to study in situ interfaces between crude oil and water in emulsions.	Water	79-84	USH1 protein network component sans	Homo sapiens	13-17
19085041-6	2009	Abnormal water metabolism was shown with AQP1, 2, 3, 4, 5 null mice, especially with AQP2 null mice: fatal at neonate due to diabetes insipidus.	Water	9-14	aquaporin 2	Mus musculus	85-89
19147154-1	2009	Chloromethylated styrene-divinylbenzene copolymers were post-crosslinked through Fredel-Crafts alkylation reaction and a water-compatible hypercrosslinked resin HJ-1 was developed successfully.	Water	121-126	jagged canonical Notch ligand 1	Homo sapiens	161-165
19303850-6	2009	Loss of Pck1p activity blocked the extension of yeast chronological life span caused by water starvation.	Water	88-93	phosphoenolpyruvate carboxykinase PCK1	Saccharomyces cerevisiae S288C	8-13
19432308-3	2009	The saturations of dissolved N2O in the North Yellow Sea showed obvious seasonal variations with higher values occurring in summer and autumn and lower in spring, and the dissolved N2O of the surface water was from undersaturated to oversaturated with the water temperature gradually increasing during three cruises in Spring.	Water	200-205	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	53-56
18776134-4	2009	To test this hypothesis, we characterized the expression of SOCS-1 and downstream apoptosis signal-regulating kinase (ASK)-1-Jun N-terminal kinase signaling molecules in small airway epithelial cells in the presence of H(2)O(2), which induces oxidative stress.	Water	219-224	mitogen-activated protein kinase kinase kinase 5	Mus musculus	82-124
18776134-6	2009	In control small airway epithelial cells exposed to H(2)O(2) or in wild-type mice exposed to 100% oxygen, a marked induction of ASK-1 and pJun N-terminal kinase was observed.	Water	52-57	mitogen-activated protein kinase kinase kinase 5	Mus musculus	128-133
19025353-15	2009	The changes of brain water content were accompanied by an alteration of AQP4.	Water	21-26	aquaporin 4	Rattus norvegicus	72-76
19156273-0	2009	MRI relaxation properties of water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide nanoparticles.	Water	29-34	ferritin heavy chain 1	Homo sapiens	43-54
19117474-6	2009	Insertion of small doses of HCN or ammonia does not change the acid/base strength of dangling hydroxyl groups or coordinately unsaturated surface oxygen atoms, but it changes the proportion between the concentrations of these sites as compared with pure water ice.	Water	254-259	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	28-31
19128029-6	2009	These new insights into the microscopic role of water molecules in Gal-1 binding to its specific carbohydrate ligands provides a better understanding of the physicochemical properties of Gal-1-saccharide interactions, which will be useful for the design of synthetic inhibitors for therapeutic purposes.	Water	48-53	galectin 1	Homo sapiens	67-72
19128029-6	2009	These new insights into the microscopic role of water molecules in Gal-1 binding to its specific carbohydrate ligands provides a better understanding of the physicochemical properties of Gal-1-saccharide interactions, which will be useful for the design of synthetic inhibitors for therapeutic purposes.	Water	48-53	galectin 1	Homo sapiens	187-192
19164545-0	2009	Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection.	Water	39-44	erythropoietin	Mus musculus	0-14
19164545-4	2009	Here we report that erythropoietin (EPO), which in recent years has emerged as a potent neuro-protective agent, antagonizes the effect of a group I mGluR agonist on astrocyte water permeability.	Water	175-180	erythropoietin	Mus musculus	20-34
19164545-4	2009	Here we report that erythropoietin (EPO), which in recent years has emerged as a potent neuro-protective agent, antagonizes the effect of a group I mGluR agonist on astrocyte water permeability.	Water	175-180	erythropoietin	Mus musculus	36-39
19164545-8	2009	In support of this conclusion we found that EPO reduced the neurological symptoms in a mouse model of primary brain edema known to depend upon AQP4 water transport.	Water	148-153	erythropoietin	Mus musculus	44-47
19222918-3	2009	Water samples are extracted using Cleanert-PEP as SPE adsorbent and ethyl acetate as elution solvent.	Water	0-5	progestagen associated endometrial protein	Homo sapiens	43-46
18843259-1	2009	Trafficking of the water channel aquaporin-2 to the apical plasma membrane of the collecting duct is mediated by arginine vasopressin, rendering the cell permeable to water.	Water	19-24	aquaporin 2	Rattus norvegicus	33-44
18843259-1	2009	Trafficking of the water channel aquaporin-2 to the apical plasma membrane of the collecting duct is mediated by arginine vasopressin, rendering the cell permeable to water.	Water	167-172	aquaporin 2	Rattus norvegicus	33-44
18843259-3	2009	Using antibodies specific for this form of the water channel, we detected rat and mouse pS269-AQP2 in the connecting tubule and throughout the collecting duct system.	Water	47-52	aquaporin 2	Mus musculus	94-98
19054354-0	2009	Metabolome and water status phenotyping of Arabidopsis under abiotic stress cues reveals new insight into ESK1 function.	Water	15-20	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	106-110
19054354-7	2009	These phenotypes are consistent with the hypothesis of an altered water status in esk1, which actually exhibited basic lower water content (WC) and transpiration rate (TR) than the WT.	Water	66-71	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	82-86
19054354-7	2009	These phenotypes are consistent with the hypothesis of an altered water status in esk1, which actually exhibited basic lower water content (WC) and transpiration rate (TR) than the WT.	Water	125-130	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	82-86
19073649-5	2009	Previous work led us to hypothesize that the protein ATEM6, one of the two Arabidopsis thaliana group 1 LEA proteins, is involved in regulating the rate at which water is lost from the maturing embryo; homozygous atem6-1 mutants display premature dehydration of seeds at the distal end of the silique.	Water	162-167	Stress induced protein	Arabidopsis thaliana	53-58
19073649-5	2009	Previous work led us to hypothesize that the protein ATEM6, one of the two Arabidopsis thaliana group 1 LEA proteins, is involved in regulating the rate at which water is lost from the maturing embryo; homozygous atem6-1 mutants display premature dehydration of seeds at the distal end of the silique.	Water	162-167	Stress induced protein	Arabidopsis thaliana	213-218
19073649-6	2009	Here we demonstrate that rehydrated, mature seeds from atem6-1 mutant plants lose more water during subsequent air drying than wild-type seeds, consistent with a role for ATEM6 protein in water binding/loss during embryo maturation.	Water	87-92	Stress induced protein	Arabidopsis thaliana	55-60
19073649-6	2009	Here we demonstrate that rehydrated, mature seeds from atem6-1 mutant plants lose more water during subsequent air drying than wild-type seeds, consistent with a role for ATEM6 protein in water binding/loss during embryo maturation.	Water	188-193	Stress induced protein	Arabidopsis thaliana	55-60
19073649-6	2009	Here we demonstrate that rehydrated, mature seeds from atem6-1 mutant plants lose more water during subsequent air drying than wild-type seeds, consistent with a role for ATEM6 protein in water binding/loss during embryo maturation.	Water	188-193	Stress induced protein	Arabidopsis thaliana	171-176
19099446-7	2009	Comparison of the OH stretch RIDIR spectrum of the third SERO-(H(2)O)(1) conformer with calculation leads to its assignment to a structure in which the water molecule forms a H-bonded bridge between the amino group and the 5-OH group of SERO, with the ethylamine side chain in the Gph(out) conformation that facilitates bridge formation, corresponding to the second most populated conformer in the isolated SERO monomer.	Water	63-68	gephyrin	Homo sapiens	281-284
19099446-7	2009	Comparison of the OH stretch RIDIR spectrum of the third SERO-(H(2)O)(1) conformer with calculation leads to its assignment to a structure in which the water molecule forms a H-bonded bridge between the amino group and the 5-OH group of SERO, with the ethylamine side chain in the Gph(out) conformation that facilitates bridge formation, corresponding to the second most populated conformer in the isolated SERO monomer.	Water	152-157	gephyrin	Homo sapiens	281-284
19099446-9	2009	The ultraviolet and infrared spectroscopy reflect the fact that the single-water bridge cannot optimally span the gap between the 5-OH and NH(2) groups, while the water dimer bridge forms a set of three strong H-bonds that lock in the Gph(out) ethylamine and anti 5-OH orientations in a near-optimal configuration.	Water	163-168	gephyrin	Homo sapiens	235-238
19499554-1	2009	Water molecules doing time: Atomic-resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex with cyclosporin A, and together with MD simulations and calorimetry, reveal how trapped water molecules influence the thermodynamic profile of a protein-ligand interaction.	Water	0-5	peptidylprolyl isomerase G	Homo sapiens	89-102
19499554-1	2009	Water molecules doing time: Atomic-resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex with cyclosporin A, and together with MD simulations and calorimetry, reveal how trapped water molecules influence the thermodynamic profile of a protein-ligand interaction.	Water	214-219	peptidylprolyl isomerase G	Homo sapiens	89-102
20408502-3	2009	Both substrate binding to CYP2F2 and metabolic clearance by CYP2F enzymes correlate with the lipophilicity, parameter, log P (where P is the octanol/water partition coefficient of the substrate).	Water	149-154	cytochrome P450, family 2, subfamily f, polypeptide 2	Mus musculus	26-32
18780324-0	2009	Luminescent sensor for Cd2+, Hg2+ and Ag+ in water based on a sulphur-containing receptor: quantitative binding-softness relationship.	Water	45-50	CD2 molecule	Homo sapiens	23-26
19098915-4	2009	Additionally, four water molecules in combination with four backbone carbonyl oxygen atoms are seen to participate in K(+) and Rb(+) ion chelation, at both the external entrance and the vestibule of the NaK filter, confirming the channel"s preference for an octahedral ligand configuration for K(+) and Rb(+) binding.	Water	19-24	TANK binding kinase 1	Homo sapiens	203-206
19098915-5	2009	In contrast, Na(+) binding in the NaK filter, particularly at site 4, utilizes a pyramidal ligand configuration that requires the participation of a water molecule in the cavity.	Water	149-154	TANK binding kinase 1	Homo sapiens	34-37
20046643-9	2009	Although DJ-1-knockdown SH-SY5Y cells were markedly vulnerable to oxidative stress, treatment with glutathione S-transferase-tagged recombinant human DJ-1 protein (GST-DJ-1) significantly inhibited H(2)O(2)-induced cell death.	Water	198-203	glutathione S-transferase kappa 1	Homo sapiens	99-124
20046643-9	2009	Although DJ-1-knockdown SH-SY5Y cells were markedly vulnerable to oxidative stress, treatment with glutathione S-transferase-tagged recombinant human DJ-1 protein (GST-DJ-1) significantly inhibited H(2)O(2)-induced cell death.	Water	198-203	Parkinsonism associated deglycase	Homo sapiens	150-154
20046643-9	2009	Although DJ-1-knockdown SH-SY5Y cells were markedly vulnerable to oxidative stress, treatment with glutathione S-transferase-tagged recombinant human DJ-1 protein (GST-DJ-1) significantly inhibited H(2)O(2)-induced cell death.	Water	198-203	Parkinsonism associated deglycase	Homo sapiens	150-154
19053233-1	2008	We have used the substituted-cysteine accessibility method (SCAM) to map the residues in the sixth membrane-spanning segment of the CB2 cannabinoid receptor that contribute to the surface of the water-accessible binding-site crevice.	Water	195-200	cannabinoid receptor 2	Homo sapiens	132-135
19174897-1	2008	The SPARC vapor pressure and activity coefficient models were coupled to successfully estimate Henry"s Law Constant (HLC) in water and in hexadecane for a wide range of organic compounds without modification to, or additional parametrization of, either SPARC model.	Water	125-130	secreted protein acidic and cysteine rich	Homo sapiens	4-9
19052371-2	2008	The thermophilic homologue of mitoNEET (TTHA0026) from Thermus thermophilus HB8 has been heterologously overproduced in Escherichia coli and purified as a water-soluble prototypal protein containing the mitoNEET-like [2Fe-2S] cluster.	Water	155-160	CDGSH iron sulfur domain 1	Homo sapiens	30-38
19052371-2	2008	The thermophilic homologue of mitoNEET (TTHA0026) from Thermus thermophilus HB8 has been heterologously overproduced in Escherichia coli and purified as a water-soluble prototypal protein containing the mitoNEET-like [2Fe-2S] cluster.	Water	155-160	CDGSH iron sulfur domain 1	Homo sapiens	203-211
18778410-5	2008	As a result of increased Prdx3 expression, mitochondria from Tg(PRDX3) mice produce significantly reduced amount of H(2)O(2), and cells from Tg(PRDX3) mice have increased resistance to stress-induced cell death and apoptosis.	Water	116-121	peroxiredoxin 3	Mus musculus	25-30
18778410-5	2008	As a result of increased Prdx3 expression, mitochondria from Tg(PRDX3) mice produce significantly reduced amount of H(2)O(2), and cells from Tg(PRDX3) mice have increased resistance to stress-induced cell death and apoptosis.	Water	116-121	peroxiredoxin 3	Mus musculus	64-69
19513364-0	2008	Content of fibronectin and glycosaminoglycans in blood serum of rats with SiO2-induced inflammation after radon-containing water bath.	Water	123-128	fibronectin 1	Rattus norvegicus	11-22
19513364-1	2008	In animals with SiO(2)-induced inflammation, exposure in radon-containing water promoted normalization of fibronectin content on days 3 and 10 and reduced the content of glycosaminoglycans on days 3 and 20 compared to the corresponding values in intact animals and rats with SiO(2)-induced inflammation not exposed to radon.	Water	74-79	fibronectin 1	Rattus norvegicus	106-117
19256381-0	2008	[Catalytic reduction of CCl4 in water by Fe0 and amended Fe0].	Water	32-37	C-C motif chemokine ligand 4	Homo sapiens	24-28
19256381-2	2008	Reductive dechlorination of toxic pollutants of CCl4 in water with Fe0 and amended Fe0 by batch experiments was investigated.	Water	56-61	C-C motif chemokine ligand 4	Homo sapiens	48-52
19256381-3	2008	Results show that CCl4 in water can be rapidly dechlorinated by above five catalytic reductants, and the presence of Cu, Ag, Pd can enhance the dechlorination rate dramatically.	Water	26-31	C-C motif chemokine ligand 4	Homo sapiens	18-22
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Water	139-144	C-C motif chemokine ligand 4	Homo sapiens	16-20
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Water	139-144	C-C motif chemokine ligand 4	Homo sapiens	131-135
18975863-3	2008	The cyclic voltammetric observation of the electrochemical oxidation and reverse reaction has allowed, with the example of 2,4,6-tri-tert-butylphenol in nonbuffered aqueous media, the clear identification of a pathway in which a phenol is directly and reversibly converted into the phenoxyl radical while the generated proton is accepted by a water molecule in a concerted manner.	Water	343-348	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	19-22
19045407-7	2008	The significant finding of this study is that the magnitudes of redshifts in the O-H stretch in the O-H-S hydrogen bonded complexes reported here are comparable to those reported for the O-H-O hydrogen bonded complexes where H(2)O acts as the H-bond acceptor, which suggests that the OH-S interaction is perhaps as strong as the OH-O interaction.	Water	225-230	Rh associated glycoprotein	Homo sapiens	100-105
18846354-2	2008	AQP5 is a ubiquitously expressed exocrine-type water channel.	Water	47-52	aquaporin 5	Homo sapiens	0-4
18653713-2	2008	Either of the genetic defects in vasopressin V2 receptor or the water channel aquaporin 2 (AQP2) cause the disease, which interfere the water reabsorption at the epithelium of the collecting duct.	Water	64-69	aquaporin 2	Homo sapiens	91-95
18653713-6	2008	When the SeV/DeltaF vector carrying a human AQP2 gene (AQP2-SeV/DeltaF) was administered retrogradely via ureter to renal pelvis, AQP2 was expressed in the renal collecting duct to reduce urine output and water intake by up to 40%.	Water	205-210	aquaporin 2	Homo sapiens	44-48
18653713-6	2008	When the SeV/DeltaF vector carrying a human AQP2 gene (AQP2-SeV/DeltaF) was administered retrogradely via ureter to renal pelvis, AQP2 was expressed in the renal collecting duct to reduce urine output and water intake by up to 40%.	Water	205-210	aquaporin 2	Homo sapiens	55-59
18653713-6	2008	When the SeV/DeltaF vector carrying a human AQP2 gene (AQP2-SeV/DeltaF) was administered retrogradely via ureter to renal pelvis, AQP2 was expressed in the renal collecting duct to reduce urine output and water intake by up to 40%.	Water	205-210	aquaporin 2	Homo sapiens	55-59
19271497-12	2008	The complexes [CeL4](OTf)3 x 2H2O and [DyL4](OTf)3 x L x 2H2O are highly-symmetrical, in which four bidentate ligands L are coordinated to Ce and Dy atoms respectively while the OTf ions and the water molecules are not coordinated.	Water	195-200	POU class 5 homeobox 1	Homo sapiens	39-50
18614997-6	2008	The physiological relevance of our in vitro data was confirmed by water deprivation of male C57BL6 mice, which caused a significant increase in serum osmolality along with induction of CLC-K1, barttin and SGK1.	Water	66-71	serum/glucocorticoid regulated kinase 1	Mus musculus	205-209
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Water	17-22	isoamylase 1	Arabidopsis thaliana	70-74
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Water	17-22	isoamylase 3	Arabidopsis thaliana	77-81
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Water	17-22	isoamylase 1	Arabidopsis thaliana	88-92
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Water	17-22	isoamylase 3	Arabidopsis thaliana	95-99
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Water	17-22	isoamylase 1	Arabidopsis thaliana	88-92
18718505-7	2008	Results showed an increase in the brain water content and the presence of Evans blue in the brain tissue of thermally injured rats, temporally associated with an increased expression of endogenous tPA and uPA.	Water	40-45	plasminogen activator, tissue type	Rattus norvegicus	197-200
18778693-5	2008	Mecp2(1lox) dams were given choline in drinking water, and pups nursed from birth to weaning.	Water	48-53	methyl CpG binding protein 2	Mus musculus	0-5
18606813-1	2008	Vasopressin controls water excretion through regulation of aquaporin-2 (AQP2) trafficking in renal collecting duct cells.	Water	21-26	aquaporin 2	Canis lupus familiaris	59-70
18606813-1	2008	Vasopressin controls water excretion through regulation of aquaporin-2 (AQP2) trafficking in renal collecting duct cells.	Water	21-26	aquaporin 2	Canis lupus familiaris	72-76
18790460-11	2008	PRP-1 maintained the initial learning level achieved in a behavioral study in a Morris water maze.	Water	87-92	tumor-associated calcium signal transducer 2	Rattus norvegicus	0-5
18596208-1	2008	In the renal collecting duct, vasopressin controls transport of water and solutes via regulation of membrane transporters such as aquaporin-2 (AQP2) and the epithelial urea transporter UT-A.	Water	64-69	aquaporin 2	Rattus norvegicus	130-141
18596208-1	2008	In the renal collecting duct, vasopressin controls transport of water and solutes via regulation of membrane transporters such as aquaporin-2 (AQP2) and the epithelial urea transporter UT-A.	Water	64-69	aquaporin 2	Rattus norvegicus	143-147
18657289-5	2008	Urinary excretion of As3 was associated with the consumption of mineral water and with residence in an industrial zone, while MMA, DMA, arsenobetaine, the sum of inorganic As+MMA+DMA and total As urinary excretion were associated with the consumption of crustaceans and/or shellfish 3 days or less before urine collection.	Water	72-77	PDS5 cohesin associated factor B	Homo sapiens	21-24
18369660-13	2008	After water deprivation, body weight decreased faster in gsk3 ( KI ) than in gsk3 ( WT ) mice.	Water	6-11	glycogen synthase kinase 3 beta	Mus musculus	57-61
18369660-15	2008	The observations disclose a role of PKB/SGK-dependent GSK3 activity in the regulation of steroid hormone release, renal water and electrolyte excretion and blood pressure control.	Water	120-125	serum/glucocorticoid regulated kinase 1	Mus musculus	40-43
18369660-15	2008	The observations disclose a role of PKB/SGK-dependent GSK3 activity in the regulation of steroid hormone release, renal water and electrolyte excretion and blood pressure control.	Water	120-125	glycogen synthase kinase 3 beta	Mus musculus	54-58
18208457-2	2008	MOX in water, at pH 7.4, shows two intense absorption bands at 287 and 338 nm (epsilon = 44,000 and 17,000 dm(3) mol(-1) cm(-1), respectively).	Water	7-12	monooxygenase DBH like 1	Homo sapiens	0-3
18511810-3	2008	A screen of sphingosine analogs identified (2R,3S,4E)-N-methyl-5-(4"-pentylphenyl)-2-aminopent-4-ene-1,3-diol, designated SK1-I (BML-258), as a potent, water-soluble, isoenzyme-specific inhibitor of SphK1.	Water	152-157	sphingosine kinase 1	Homo sapiens	122-125
18548281-0	2008	Immunolocalization of a mammalian aquaporin 3 homolog in water-transporting epithelial cells in several organs of the clawed toad Xenopus laevis.	Water	57-62	aquaporin 3 (Gill blood group)	Homo sapiens	34-45
19048093-4	2008	Understanding the history of water on Mars appears to be one of the clues to the puzzle on the probability of life on Mars.	Water	29-34	methionyl-tRNA synthetase 1	Homo sapiens	38-42
19048093-4	2008	Understanding the history of water on Mars appears to be one of the clues to the puzzle on the probability of life on Mars.	Water	29-34	methionyl-tRNA synthetase 1	Homo sapiens	118-122
18625374-6	2008	Immunohistochemically, while aquaporin 5 (AQP5), one of the water channel AQP families, was present exclusively in the dark cells of sweat glands of healthy donors, an aberrant AQP5 staining, extending to the clear cells, was found in the patient with AWP.	Water	60-65	aquaporin 5	Homo sapiens	29-40
18625374-6	2008	Immunohistochemically, while aquaporin 5 (AQP5), one of the water channel AQP families, was present exclusively in the dark cells of sweat glands of healthy donors, an aberrant AQP5 staining, extending to the clear cells, was found in the patient with AWP.	Water	60-65	aquaporin 5	Homo sapiens	42-46
20142913-9	2008	There is a marked downregulation of both AQP2 and AQP3 expression, which could be a physiologic response to extracellular water reabsorption in patients with nephrotic syndrome.	Water	122-127	aquaporin 2	Homo sapiens	41-45
20142913-9	2008	There is a marked downregulation of both AQP2 and AQP3 expression, which could be a physiologic response to extracellular water reabsorption in patients with nephrotic syndrome.	Water	122-127	aquaporin 3 (Gill blood group)	Homo sapiens	50-54
18549677-0	2008	Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro.	Water	51-56	heart and neural crest derivatives expressed 2	Mus musculus	78-81
17957381-1	2008	It has been the general consensus that cAMP-mediated PKA-dependent phosphorylation of aquaporin-2 is the primary mechanism of vasopressin to regulate osmotic water permeability in kidney collecting duct.	Water	158-163	aquaporin 2	Homo sapiens	86-97
18502184-1	2008	AIM: To examine the effect of nitric oxide (NO) on the expression and/or localization of inner medulla collecting duct aquaporin-2 water channel (AQP2) in young and adult hemorrhaged anesthetized rats.	Water	131-136	aquaporin 2	Rattus norvegicus	146-150
18839520-2	2008	METHODS: A pilot distribution network was built and water quality detection was made on popular pipelines of galvanized iron pipe, PPR and ABS plastic pipes by ESEM (environmental scanning electron microscopy).	Water	52-57	PPR1	Homo sapiens	131-134
18841780-8	2008	Stool water content increased in diarrheic dose group and High dose group, expression of AQP2 decreased evidently in these two groups (P &lt; 0.01).	Water	6-11	aquaporin 2	Rattus norvegicus	89-93
18495115-1	2008	For understanding the actions of magnesium formulations, magnesium oxide and magnesium sulfate as a constituent of antacid, in the gastrointestinal tract, the effect of magnesium ion on the water channel aquaporin 3 (AQP3) known to be permeable mainly to water and glycerol was investigated in Caco-2 cells.	Water	190-195	aquaporin 3 (Gill blood group)	Homo sapiens	204-215
18495115-1	2008	For understanding the actions of magnesium formulations, magnesium oxide and magnesium sulfate as a constituent of antacid, in the gastrointestinal tract, the effect of magnesium ion on the water channel aquaporin 3 (AQP3) known to be permeable mainly to water and glycerol was investigated in Caco-2 cells.	Water	190-195	aquaporin 3 (Gill blood group)	Homo sapiens	217-221
18512960-12	2008	The dependence of the occurrence of methyl transfer on the formation of a water channel in SET8 is in accord with our previous reports on product specificity by histone lysine monomethyltransferase SET7/9, large subunit lysine dimethyltransferase (LSMT), and viral histone lysine trimethyltransferase (vSET).	Water	74-79	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	198-204
18605575-1	2008	Lipid-free polyethylene membrane tubing (LFT) has been further developed in response to a growing need for an inexpensive and simple time-integrative sampling device for dissolved hydrophobic contaminants in water.	Water	208-213	limb and CNS expressed 1	Homo sapiens	41-44
18430448-10	2008	Our results confirm that the rPP2Ac we prepared is an excellent tool for detecting and quantifying microcystins in water.	Water	115-120	POP5 homolog, ribonuclease P/MRP subunit	Rattus norvegicus	29-33
18489147-4	2008	We demonstrate that SARS FP strongly partitions into phospholipid membranes, more specifically with those containing negatively charged phospholipids, increasing the water penetration depth and displaying membrane-activity modulated by the lipid composition of the membrane.	Water	166-171	seryl-tRNA synthetase 1	Homo sapiens	20-24
18489147-5	2008	Interestingly, peptide organization is different depending if SARS FP is in water or bound to the membrane.	Water	76-81	seryl-tRNA synthetase 1	Homo sapiens	62-66
18423983-2	2008	Here, we demonstrate that ectopic expression of human AQP5 (hAQP5), a water channel expressed in lung, salivary glands, and kidney, induces many phenotypic changes characteristic of transformation both in vitro and in vivo.	Water	70-75	aquaporin 5	Homo sapiens	54-58
18423983-2	2008	Here, we demonstrate that ectopic expression of human AQP5 (hAQP5), a water channel expressed in lung, salivary glands, and kidney, induces many phenotypic changes characteristic of transformation both in vitro and in vivo.	Water	70-75	aquaporin 5	Homo sapiens	60-65
18459808-1	2008	Treatment of alkenes with NBS, a nitrile, NaHCO3 and water in the presence of Cu(OTf)2 or Zn(OTf)2 is reported to furnish oxazolines in one pot and good yields.	Water	53-58	nibrin	Homo sapiens	26-29
18167118-0	2008	Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes.	Water	31-36	aquaporin 4	Rattus norvegicus	53-64
18405950-7	2008	Several genes were in common between the EtOH and both the SAC and water groups in the synaptic transmission (e.g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories.	Water	67-72	neurexin 3	Rattus norvegicus	122-127
18405950-7	2008	Several genes were in common between the EtOH and both the SAC and water groups in the synaptic transmission (e.g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories.	Water	67-72	homer scaffold protein 1	Rattus norvegicus	143-149
18435676-1	2008	BACKGROUND: The human GIL blood group is encoded by the aquaporin 3 (AQP3), a water-glycerol channel present in human red cell (RBC) membranes.	Water	78-83	aquaporin 3 (Gill blood group)	Homo sapiens	56-67
18435676-1	2008	BACKGROUND: The human GIL blood group is encoded by the aquaporin 3 (AQP3), a water-glycerol channel present in human red cell (RBC) membranes.	Water	78-83	aquaporin 3 (Gill blood group)	Homo sapiens	69-73
18322140-7	2008	Acclimation to both acidic and low-Na+ fresh water caused upregulation of zca15a expression but did not change the zca2-like a mRNA level in zebrafish gills.	Water	45-50	carbonic anhydrase XVa	Danio rerio	74-80
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Water	173-178	aquaporin 2	Rattus norvegicus	94-105
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Water	284-289	aquaporin 2	Rattus norvegicus	94-105
17671846-7	2008	The presence of various water masses [Arabian Sea High Salinity Water (ASHSW), Persian Gulf Water (PGW), Red Sea Water (RSW)] and their seasonal variations in the region is discussed and their decreasing influence towards the south is noted during both periods of observation.	Water	24-29	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	46-49
18202915-0	2008	Monitoring of cholinesterase-inhibiting activity in water from the Tone canal, Japan, as a biomarker of ecotoxicity.	Water	52-57	butyrylcholinesterase	Homo sapiens	14-28
18449356-3	2008	Recently, the absence of transcripts of the water channel, aquaporin-5 (AQP5), was demonstrated by reverse-transcription polymerase chain reaction (RT-PCR) in KC tissues and was proposed as a possible marker for KC.	Water	44-49	aquaporin 5	Homo sapiens	59-70
18449356-3	2008	Recently, the absence of transcripts of the water channel, aquaporin-5 (AQP5), was demonstrated by reverse-transcription polymerase chain reaction (RT-PCR) in KC tissues and was proposed as a possible marker for KC.	Water	44-49	aquaporin 5	Homo sapiens	72-76
18342434-4	2008	The data obtained indicated that AEA administered via water modulates the transcription of its own receptor CB1, besides to up-regulate gene expression of sterol regulatory element binding protein (SREBP) and of the insulin-like growth factors (IGF-1 and IGF-2).	Water	54-59	insulin-like growth factor 2a	Danio rerio	255-260
18286643-2	2008	Here, we report that glutamate increases astrocyte water permeability and that the molecular target for this effect is the aquaporin-4 (AQP4) serine 111 residue, which is in a strategic position for control of the water channel gating.	Water	51-56	aquaporin 4	Rattus norvegicus	123-134
18286643-2	2008	Here, we report that glutamate increases astrocyte water permeability and that the molecular target for this effect is the aquaporin-4 (AQP4) serine 111 residue, which is in a strategic position for control of the water channel gating.	Water	51-56	aquaporin 4	Rattus norvegicus	136-140
18286643-2	2008	Here, we report that glutamate increases astrocyte water permeability and that the molecular target for this effect is the aquaporin-4 (AQP4) serine 111 residue, which is in a strategic position for control of the water channel gating.	Water	214-219	aquaporin 4	Rattus norvegicus	123-134
18286643-2	2008	Here, we report that glutamate increases astrocyte water permeability and that the molecular target for this effect is the aquaporin-4 (AQP4) serine 111 residue, which is in a strategic position for control of the water channel gating.	Water	214-219	aquaporin 4	Rattus norvegicus	136-140
18342304-4	2008	Western blots show that Xt egg water contains a single anti-allurin cross-reactive protein whose molecular weight (20,497 Da by MALDI MS) agrees well with the molecular weight of the hypothetical gene product for a newly recognized "Crisp A" gene in the X. tropicalis genome.	Water	31-36	cysteine-rich secretory protein 1 gene 5 S homeolog	Xenopus laevis	233-238
18329655-3	2008	Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 microg/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.	Water	160-165	transition protein 1	Homo sapiens	140-143
18329655-3	2008	Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 microg/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.	Water	160-165	transition protein 2	Homo sapiens	148-151
18715941-2	2008	Hypernatremia is commonly considered a secondary sign caused by the net loss of water due to insufficient insertion of aquaporin-2 water channels into the apical membrane of the collecting duct cells.	Water	80-85	aquaporin 2	Mus musculus	119-130
18715941-2	2008	Hypernatremia is commonly considered a secondary sign caused by the net loss of water due to insufficient insertion of aquaporin-2 water channels into the apical membrane of the collecting duct cells.	Water	131-136	aquaporin 2	Mus musculus	119-130
18214481-6	2008	EGF-induced cell migration is inhibited by specific AQP3 siRNA knockdown or AQP3 water transport inhibitor CuSO4 and NiCl2.	Water	81-86	aquaporin 3 (Gill blood group)	Homo sapiens	76-80
18675987-3	2008	The immediately prepared films were easily broken into particles to form colloidal-like dilute suspension of the silica-polyamide composite particles in D(2)O-H(2)O solutions for SANS measurements, that in this dilute system SANS data the complication of scattering data from the interacting particles is minimized.	Water	159-164	USH1 protein network component sans	Homo sapiens	225-229
18840656-9	2008	mRNA expression of a newly cloned Rhbg2 cDNA was downregulated in the skin of fish exposed to buffered water, and Rhag mRNA expression in erythrocytes was decreased with exposure to normocapnia in buffered water but not with hypercapnia exposure in either buffered or unbuffered water.	Water	206-211	Rhag	Oncorhynchus mykiss	114-118
29993059-2	2018	Many complexes of the type BMX, (where B is a Lewis base such as H2, N2, ethyne, ethene, cyclopropane, H2O, H2S, PH3, or NH3, M is a coinage-metal atom Cu, Ag or Au, and X is a halogen atom) have now been characterised in the gas phase through their rotational spectra.	Water	103-106	BMX non-receptor tyrosine kinase	Homo sapiens	27-30
18840656-9	2008	mRNA expression of a newly cloned Rhbg2 cDNA was downregulated in the skin of fish exposed to buffered water, and Rhag mRNA expression in erythrocytes was decreased with exposure to normocapnia in buffered water but not with hypercapnia exposure in either buffered or unbuffered water.	Water	206-211	Rhag	Oncorhynchus mykiss	114-118
18664568-2	2008	We investigated the effects of acute hypertonic challenge on AQP2 (aquaporin-2) water channel trafficking.	Water	80-85	aquaporin 2	Rattus norvegicus	61-65
18664568-2	2008	We investigated the effects of acute hypertonic challenge on AQP2 (aquaporin-2) water channel trafficking.	Water	80-85	aquaporin 2	Rattus norvegicus	67-78
18772393-5	2008	As the more isotopically positive shallow-water carbonate sediments are only produced when the platforms are flooded, there is a connection between changes in global sea level and the delta(13)C of sediments in marginal settings.	Water	42-47	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	166-169
29758386-5	2018	Also, when compared to continuous alcohol access or access to water alone, NK1R expression was increased in the nucleus accumbens (NAC) and dorsal striatum, but not the amygdala.	Water	62-67	tachykinin receptor 1	Rattus norvegicus	75-79
29897749-4	2018	In addition, in hIDO1, the indoleamine group of the substrate Trp is H-bonded to S167 through a bridging water, while that in hTDO is directly H-bonded to H76.	Water	105-110	indoleamine 2,3-dioxygenase 1	Homo sapiens	16-21
29966028-1	2018	The movement of water and ions in sodium alumino-silicate hydrate gel (NASH) influences the physical and chemical properties of the geopolymer material.	Water	16-21	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	71-75
18768791-1	2008	Human aquaporin 5 (HsAQP5) facilitates the transport of water across plasma membranes and has been identified within cells of the stomach, duodenum, pancreas, airways, lungs, salivary glands, sweat glands, eyes, lacrimal glands, and the inner ear.	Water	56-61	aquaporin 5	Homo sapiens	6-17
29966028-2	2018	In this paper, in order to better understand the structure and dynamics of water and ions in the interfacial region of the NASH gel, molecular dynamics was utilized to model Na2SO4 and MgSO4 solutions (both at 0.44 mol L-1) near the NASH surface.	Water	75-80	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	123-127
29986511-6	2018	Solvation effect analysis revealed that solvent-water enhanced molecular recognition between PD-L1 and nanobody.	Water	48-53	CD274 molecule	Homo sapiens	93-98
29729477-8	2018	The reproductive success was higher in fish exposed to ozonated effluent compared to non-ozonated effluent and to tap water.	Water	118-123	transporter associated with antigen processing, subunit type c	Danio rerio	114-117
29635137-0	2018	Improvements in the water dispersibility of paclitaxel by complexing with synthetic peptides derived from beta-casein.	Water	20-25	casein beta	Homo sapiens	106-117
29875071-9	2018	Recent molecular epidemiology has indicated that activation of brominated trihalomethanes by the enzyme GSTT1 and the lack of metabolism of haloacetic acids by a variant of enzyme GSTZ1 are likely causative mechanisms for bladder cancer associated with exposure to chlorinated water.	Water	277-282	glutathione S-transferase zeta 1	Homo sapiens	180-185
29963136-6	2018	Analysis of cell permeability to water and glycerol revealed that MDA-MB-231 cells with knocked down AQP3 demonstrated a modest decrease in water permeability (17%; P&lt;0.05) but a more marked decrease in glycerol permeability (77%; P&lt;0.001).	Water	33-38	aquaporin 3 (Gill blood group)	Homo sapiens	101-105
29963136-6	2018	Analysis of cell permeability to water and glycerol revealed that MDA-MB-231 cells with knocked down AQP3 demonstrated a modest decrease in water permeability (17%; P&lt;0.05) but a more marked decrease in glycerol permeability (77%; P&lt;0.001).	Water	140-145	aquaporin 3 (Gill blood group)	Homo sapiens	101-105
30008416-1	2018	The Mediterranean Sea is a closed basin with limited water exchange through the Strait of Gibraltar, and sites along its shores show the greatest densities of marine debris in the world.	Water	53-58	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	18-21
29947533-1	2018	The endothelin (ET) and prorenin/renin/prorenin receptor (PRR) systems have opposing physiological effects on collecting duct (CD) salt and water reabsorption.	Water	140-145	endothelin 1	Mus musculus	4-14
29921834-1	2018	BACKGROUND Aquaporin 4 (AQP4), the most abundant aquaporin in the brain, is a type of bidirectional water channel controlling the brain-water balance and plays a critical role in physiologic and pathologic water balance in the brain.	Water	100-105	aquaporin 4	Rattus norvegicus	11-22
29921834-1	2018	BACKGROUND Aquaporin 4 (AQP4), the most abundant aquaporin in the brain, is a type of bidirectional water channel controlling the brain-water balance and plays a critical role in physiologic and pathologic water balance in the brain.	Water	100-105	aquaporin 4	Rattus norvegicus	24-28
29921834-1	2018	BACKGROUND Aquaporin 4 (AQP4), the most abundant aquaporin in the brain, is a type of bidirectional water channel controlling the brain-water balance and plays a critical role in physiologic and pathologic water balance in the brain.	Water	136-141	aquaporin 4	Rattus norvegicus	11-22
18339903-0	2008	Impact of artificial reservoir water impoundment on global sea level.	Water	31-36	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	59-62
18339903-1	2008	By reconstructing the history of water impoundment in the world"s artificial reservoirs, we show that a total of approximately 10,800 cubic kilometers of water has been impounded on land to date, reducing the magnitude of global sea level (GSL) rise by -30.0 millimeters, at an average rate of -0.55 millimeters per year during the past half century.	Water	154-159	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	229-232
29921834-1	2018	BACKGROUND Aquaporin 4 (AQP4), the most abundant aquaporin in the brain, is a type of bidirectional water channel controlling the brain-water balance and plays a critical role in physiologic and pathologic water balance in the brain.	Water	136-141	aquaporin 4	Rattus norvegicus	24-28
29874605-3	2018	Here, by combining experiments and simulations, we show the existence of dynamical heterogeneity of hydration water in an intrinsically disordered presynaptic protein, namely alpha-synuclein, implicated in Parkinson"s disease.	Water	110-115	synuclein alpha	Homo sapiens	175-190
18263714-11	2008	In conclusion, these results support the notion that when Lzm-S interacts with the arterial vasculature, this interaction results in the formation of H(2)O(2), which, in turn, activates the sGC pathway to cause relaxation.	Water	150-155	MAA	Homo sapiens	58-63
29874605-10	2018	Additionally, our simulations allowed us to decipher the molecular origin of the dynamical heterogeneity of water in alpha-synuclein.	Water	108-113	synuclein alpha	Homo sapiens	117-132
29582200-3	2018	Therefore, in the current study, we investigated whether hot-water extracts of specific livestock by-products induce the expression of adiponectin in mouse 3T3-L1 adipocytes.	Water	61-66	adiponectin, C1Q and collagen domain containing	Mus musculus	135-146
18255328-8	2008	The AbTRx-2 mRNA was up-regulated in gill and digestive tract tissues initially at 3 h post-injection of H(2)O(2) and maintained higher level at 6 h. Our results suggest that abalone TRx-2 may play an important role in regulating oxidative stress in mitochondria by catalyzing protein disulfide reduction, scavenging of ROS, and minimizing the DNA damage.	Water	105-110	thioredoxin 2	Homo sapiens	6-11
29530595-6	2018	Here, pulsed and continuous wave (CW) EPR demonstrate that water-bridged complexes are remarkably common among a range of nitrogenous drugs or drug fragments that bind to CYP3A4 or CYP2C9.	Water	59-64	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	181-187
18637345-3	2008	CAS was insignificantly exposed to the properties of suspended particles, so preferable flocculation efficiency by it could be obtained both with distilled water and tap water kaolin suspensions.	Water	156-161	BCAR1 scaffold protein, Cas family member	Homo sapiens	0-3
18637345-3	2008	CAS was insignificantly exposed to the properties of suspended particles, so preferable flocculation efficiency by it could be obtained both with distilled water and tap water kaolin suspensions.	Water	170-175	BCAR1 scaffold protein, Cas family member	Homo sapiens	0-3
18536896-3	2008	By the end of 8 months of the therapy, he could walk independently, was able to pick glassful of water and keeping away after drinking, was using disyllabic words meaningfully, could indicate for hunger and toilet and was able to recognize the parents and self.	Water	97-102	protein interacting with PRKCA 1	Homo sapiens	80-84
29458189-5	2018	In addition to using the conventional monoexponential tensor model to assess TOD-related fluctuations, we used a dual compartment tensor model that allowed us to directly assess if any change in DTI measures is due to an increase in CSF/free-water volume fraction or due to an increase in water diffusivity within the parenchyma.	Water	289-294	colony stimulating factor 2	Homo sapiens	233-236
18251503-0	2008	Peroxidase-mediated oxidative cross-linking and its potential to modify mechanical properties in water-soluble polysaccharide extracts and cereal grain residues.	Water	97-102	peroxidase-like	Triticum aestivum	0-10
29458189-9	2018	The dual compartment analysis revealed that the increase in diffusivity measures from PM to AM was driven by an increase in the volume fraction of CSF-like free-water.	Water	161-166	colony stimulating factor 2	Homo sapiens	147-150
18260647-5	2008	The lack of formation of a water channel is due to the positioning of the methyl substituent of the SET7/9.p53-Lys4-N(Me)H 2 (+).AdoMet complex.	Water	27-32	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	100-106
29578858-1	2018	PURPOSE: This study aimed to investigate the effects of water-based aerobic training on the lipid profile and lipoprotein lipase (LPL) levels in premenopausal women with dyslipidemia.	Water	56-61	lipoprotein lipase	Homo sapiens	110-128
18421596-2	2008	Lipase from C. antarctica was further studied to verify the enzyme load (wt% of oil mass), the molar ratio glycerol/oil, and the water content (wt% of glycerol) on the glycerolysis reaction.	Water	129-134	PAN0_003d1715	Moesziomyces antarcticus	0-6
29578858-1	2018	PURPOSE: This study aimed to investigate the effects of water-based aerobic training on the lipid profile and lipoprotein lipase (LPL) levels in premenopausal women with dyslipidemia.	Water	56-61	lipoprotein lipase	Homo sapiens	130-133
18425614-2	2008	The bioreactors employed a unique type of hydrogenase activity found in some photosynthetic bacteria that functions in darkness to shift CO (and H2O) into H(2) (and CO2).	Water	145-149	complement C2	Homo sapiens	165-168
29799507-7	2018	After the first application of BBP for mycotoxin binding, BBP could be completely reactivated through the elimination of ZEN from the cyclodextrin cavities by washing with a 50 v/v% ethanol-water mixture.	Water	190-195	TM2 domain containing 1	Homo sapiens	31-34
18424370-3	2008	In this study, the effects of a water-soluble extract of Rosmarinus officinalis (Ro) on the expression of UV-induced MMP-1 were investigated.	Water	32-37	matrix metallopeptidase 1	Homo sapiens	117-122
29799507-7	2018	After the first application of BBP for mycotoxin binding, BBP could be completely reactivated through the elimination of ZEN from the cyclodextrin cavities by washing with a 50 v/v% ethanol-water mixture.	Water	190-195	TM2 domain containing 1	Homo sapiens	58-61
18424370-9	2008	All together, from molecular to tissue level, these results illustrate the ability of the Ro water-soluble extract to inhibit UV-induced MMP-1 and its potential benefits in preventing cutaneous photodamage.	Water	93-98	matrix metallopeptidase 1	Homo sapiens	137-142
29864360-1	2018	In water, networks of semiflexible fibrils of the protein alpha-synuclein stiffen significantly with increasing temperature.	Water	3-8	synuclein alpha	Homo sapiens	58-73
29930728-4	2018	The 2D probe is constructed through supramolecular self-assembly between a water soluble, fluorescent peptide ligand that selectively targets glypican-3 (GPC-3, a specific cell-surface biomarker for HCC) and 2D molybdenum disulfide that acts as a fluorescence quencher as well as imaging enhancer.	Water	75-80	glypican 3	Homo sapiens	154-159
18518828-9	2008	In mice with airway-specific overexpression of epithelial Na(+) channels (ENaC), which constitute a rate limiting pathway for absorption of salt and water from airway surfaces, ASL depletion caused reduced mucus clearance, and a spontaneous chronic airway disease with mucus obstruction, goblet cell metaplasia, chronic inflammation, reduced bacterial clearance, and high pulmonary mortality.	Water	149-154	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	47-72
18518828-9	2008	In mice with airway-specific overexpression of epithelial Na(+) channels (ENaC), which constitute a rate limiting pathway for absorption of salt and water from airway surfaces, ASL depletion caused reduced mucus clearance, and a spontaneous chronic airway disease with mucus obstruction, goblet cell metaplasia, chronic inflammation, reduced bacterial clearance, and high pulmonary mortality.	Water	149-154	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	74-78
29652491-3	2018	We show that PAP-1 forms stable dimers in water, primarily through hydrophobic interactions between aromatic rings.	Water	42-47	lipin 1	Homo sapiens	13-18
18216318-8	2008	Treatment with cyclosporine A improves the regulation of solute and water by preventing the downregulation of aquaporin-2 and epithelial sodium channel, even though many other transporter genes remain downregulated.	Water	68-73	aquaporin 2	Rattus norvegicus	110-121
29648807-0	2018	Density of Grafted Chains in Thioglycerol-Capped CdS Quantum Dots Determines Their Interaction with Aluminum(III) in Water.	Water	117-122	CDP-diacylglycerol synthase 1	Homo sapiens	49-52
17659831-1	2008	Photocatalytic decomposition of CCl4 (80 mg L(-1) in H2O) effected by Zr-MCM-41 (Zr incorporated in the amorphous wall of MCM-41) has been studied in the present work.	Water	53-56	C-C motif chemokine ligand 4	Homo sapiens	32-36
29648807-1	2018	We aimed to quantify the interaction of water-soluble-functionalized CdS quantum dots (QDs) with metal cations from their composition and physical properties.	Water	40-45	CDP-diacylglycerol synthase 1	Homo sapiens	69-72
18382061-5	2008	RESULTS: The brain water content and the expression of AQP4 in the target area and the peripheral zone obviously increased at 12 h after Gamma knife radiation, and achieved the peak after 2 d. It was still higher than normal after 14 d. The gray value of expression of aquaporin-4 was negatively related to brain water content (r=-0.9857, P&lt;0.05).	Water	19-24	aquaporin 4	Rattus norvegicus	269-280
29357422-2	2018	Lithium-induced NDI is caused by lithium uptake by collecting duct principal cells and altered expression of aquaporin-2 (AQP2), which are essential for water reabsorption of tubular fluid in the collecting duct.	Water	153-158	aquaporin 2	Rattus norvegicus	109-120
18382061-5	2008	RESULTS: The brain water content and the expression of AQP4 in the target area and the peripheral zone obviously increased at 12 h after Gamma knife radiation, and achieved the peak after 2 d. It was still higher than normal after 14 d. The gray value of expression of aquaporin-4 was negatively related to brain water content (r=-0.9857, P&lt;0.05).	Water	313-318	aquaporin 4	Rattus norvegicus	55-59
18382061-5	2008	RESULTS: The brain water content and the expression of AQP4 in the target area and the peripheral zone obviously increased at 12 h after Gamma knife radiation, and achieved the peak after 2 d. It was still higher than normal after 14 d. The gray value of expression of aquaporin-4 was negatively related to brain water content (r=-0.9857, P&lt;0.05).	Water	313-318	aquaporin 4	Rattus norvegicus	269-280
18698836-4	2008	These findings suggested that CAd could be stabilized at the membrane-water interface with its CNZ moiety stacked at the GABA A-R while its acyl chain can be inserted into the membrane depth.	Water	70-75	aconitate decarboxylase 1	Homo sapiens	30-33
18758838-1	2008	OBJECTIVE: This work compares the measured R*2 of magnetic nanoparticles to their corresponding theoretical values in both gel phantoms and dynamic water flows on the basis of the static dephasing theory.	Water	148-153	ribonucleotide reductase regulatory subunit M2	Homo sapiens	43-46
18232676-1	2008	Molecular dynamics simulations were carried out to study solvent effects on the energetic and dynamical properties of water molecules in liquid water and in carbon tetrachloride (CCl4).	Water	118-123	C-C motif chemokine ligand 4	Homo sapiens	179-183
18232676-4	2008	The difference in free energy in water as compared to that in CCl4 was expected and is the result of competition from surrounding water molecules that are capable of forming hydrogen bonds in the liquid water.	Water	33-38	C-C motif chemokine ligand 4	Homo sapiens	62-66
18232676-4	2008	The difference in free energy in water as compared to that in CCl4 was expected and is the result of competition from surrounding water molecules that are capable of forming hydrogen bonds in the liquid water.	Water	130-135	C-C motif chemokine ligand 4	Homo sapiens	62-66
18232676-4	2008	The difference in free energy in water as compared to that in CCl4 was expected and is the result of competition from surrounding water molecules that are capable of forming hydrogen bonds in the liquid water.	Water	130-135	C-C motif chemokine ligand 4	Homo sapiens	62-66
18232676-5	2008	This capability is absent in the diluted water found in CCl4.	Water	41-46	C-C motif chemokine ligand 4	Homo sapiens	56-60
29357422-2	2018	Lithium-induced NDI is caused by lithium uptake by collecting duct principal cells and altered expression of aquaporin-2 (AQP2), which are essential for water reabsorption of tubular fluid in the collecting duct.	Water	153-158	aquaporin 2	Rattus norvegicus	122-126
18232676-13	2008	For diluted water in CCl4, we found the computed rotational correlation times also were nonisotropic and much longer than the corresponding NMR experimental values at the same concentration (Farrar; et al.	Water	12-17	C-C motif chemokine ligand 4	Homo sapiens	21-25
29523543-1	2018	The stratified water column of the Black Sea serves as a model ecosystem for studying the interactions of microorganisms with major biogeochemical cycles.	Water	15-20	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	41-44
18232676-17	2008	Upon analyzing the water hydrogen-bonding patterns as a function of water concentration, we conclude that the differences in the rotational correlation times mainly result from the formation of water hydrogen-bonding networks as the water concentration is increased in liquid CCl4.	Water	19-24	C-C motif chemokine ligand 4	Homo sapiens	276-280
18232676-17	2008	Upon analyzing the water hydrogen-bonding patterns as a function of water concentration, we conclude that the differences in the rotational correlation times mainly result from the formation of water hydrogen-bonding networks as the water concentration is increased in liquid CCl4.	Water	68-73	C-C motif chemokine ligand 4	Homo sapiens	276-280
18232676-17	2008	Upon analyzing the water hydrogen-bonding patterns as a function of water concentration, we conclude that the differences in the rotational correlation times mainly result from the formation of water hydrogen-bonding networks as the water concentration is increased in liquid CCl4.	Water	68-73	C-C motif chemokine ligand 4	Homo sapiens	276-280
18232676-17	2008	Upon analyzing the water hydrogen-bonding patterns as a function of water concentration, we conclude that the differences in the rotational correlation times mainly result from the formation of water hydrogen-bonding networks as the water concentration is increased in liquid CCl4.	Water	68-73	C-C motif chemokine ligand 4	Homo sapiens	276-280
18335234-2	2008	We recently reported that decreased expression and function of Na+/H+ exchanger type 3 (NHE-3) in proximal tubules and epithelial Na+ channels and aquaporin 2 in collecting ducts are major mechanisms involved in Na+ and water imbalances shortly after transplantation in rat undergoing acute rejection.	Water	220-225	aquaporin 2	Rattus norvegicus	147-158
29634258-5	2018	In particular, closely aligned chromophores in the MOF facilitate a long-range 3D triplet diffusion of 1.6 mum allowing efficient energy migration in water.	Water	150-155	K(lysine) acetyltransferase 8	Mus musculus	51-54
29577127-2	2018	One alternative is zein, a water-insoluble protein from corn.	Water	27-32	zein	Zea mays	19-23
19069647-0	2008	[Induction of CYP1A1 expression of H4IIE cell after treated with the water organic pollutants from the Yangtze River and Jialing River].	Water	69-74	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20
18003606-6	2008	AdamantylGb3, a water-soluble Gb3 mimic, but not other GSL analogs, reversed MDR1-MDCK cell drug resistance.	Water	16-21	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	9-12
18678705-1	2008	Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane and its vasopressin and protein kinase A (PKA)-dependent regulation in renal collecting ducts is critical for body water homeostasis.	Water	15-20	aquaporin 2	Homo sapiens	42-46
29577127-7	2018	Dilute suspensions are prepared to measure the extinction cross section of individual particles and this was combined with Mie theory to determine a refractive index (RI) of 1.49 +- 0.01 for zein particles dispersed in water.	Water	219-224	zein	Zea mays	191-195
17989139-0	2008	Effects of hindbrain melanin-concentrating hormone and neuropeptide Y administration on licking for water, saccharin, and sucrose solutions.	Water	100-105	neuropeptide Y	Homo sapiens	55-69
29650969-2	2018	Congenital NDI is mainly caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R), leading to impaired aquaporin-2 (AQP2) water channel activity.	Water	143-148	aquaporin 2	Homo sapiens	124-135
18006322-4	2008	In the course of making the structural modifications, we discovered that a novel pyrazole derivative 6b (CBS0550) had high affinity for the CB(2) receptor (IC(50)=2.9 nM, EC(50)=1.8 nM, E(max)=85%), high selectivity for CB(2) (CB(1) IC(50)/CB(2) IC(50)=1400), and good physicochemical properties (solubility in water: 5.9 mg/100mL at 25 degrees C).	Water	311-316	cannabinoid receptor 2	Rattus norvegicus	140-154
19325809-3	2008	In this study, the soluble hot-water extract of those ultra-fine granules of red ginseng (URG) was investigated and compared to that of the normal-sized granules of red ginseng (RG).	Water	31-36	epidermal growth factor	Homo sapiens	90-93
19325809-4	2008	The high pressure liquid chromatographic analyses of the soluble hot-water extracts of both URG and RG revealed that URG had about 2-fold higher amounts of the ginsenosides, the biologically active components in red ginseng, than RG did.	Water	69-74	epidermal growth factor	Homo sapiens	117-120
18006322-4	2008	In the course of making the structural modifications, we discovered that a novel pyrazole derivative 6b (CBS0550) had high affinity for the CB(2) receptor (IC(50)=2.9 nM, EC(50)=1.8 nM, E(max)=85%), high selectivity for CB(2) (CB(1) IC(50)/CB(2) IC(50)=1400), and good physicochemical properties (solubility in water: 5.9 mg/100mL at 25 degrees C).	Water	311-316	cannabinoid receptor 2	Rattus norvegicus	140-145
29650969-2	2018	Congenital NDI is mainly caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R), leading to impaired aquaporin-2 (AQP2) water channel activity.	Water	143-148	aquaporin 2	Homo sapiens	137-141
19325809-7	2008	These results suggest that some biologically active and soluble components in red ginseng can be more effectively extracted from URG than RG by standard hot-water extraction.	Water	157-162	epidermal growth factor	Homo sapiens	129-132
17893913-0	2008	Aquaporin-4 water channels in enteric neurons.	Water	12-17	aquaporin 4	Rattus norvegicus	0-11
29528632-7	2018	Remarkably, FtsH overcomes the dual-energetic burden of substrate unfolding and membrane dislocation with the ATP cost comparable to that for water-soluble substrates by robust ClpAP/XP proteases.	Water	142-147	YME1 like 1 ATPase	Homo sapiens	12-16
17893913-1	2008	Aquaporin-4 is a water channel predominantly found in astrocytes in the central nervous system and is believed to play a critical role in the formation and maintenance of the blood-brain barrier and in water secretion from the brain.	Water	17-22	aquaporin 4	Rattus norvegicus	0-11
17893913-1	2008	Aquaporin-4 is a water channel predominantly found in astrocytes in the central nervous system and is believed to play a critical role in the formation and maintenance of the blood-brain barrier and in water secretion from the brain.	Water	202-207	aquaporin 4	Rattus norvegicus	0-11
29413812-4	2018	We found that at pH1 there was a disruption in water solvation around the basal and the ice binding surfaces of the molecule.	Water	47-52	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	17-20
17945247-3	2008	The decreasing trend in C1 and C3 coefficients, which are the function of E1 and E3 Racah f-interelectron repulsion parameters, is evidence of the magnification of covalence in Ln-O bond in the series triple bond S-iO(1/3Ln)-Al triple bond &lt;Ln(H2O)3+ x &lt;Ln(NO3) n-3 n. The adsorption isotherms of the lanthanides, registered for total lanthanide nitrate concentrations (0.0001-0.001 mol/dm3), were found to be a Freundlich type.	Water	247-250	small nucleolar RNA, H/ACA box 73A	Homo sapiens	74-91
18641360-2	2008	The Th2 cytokines IL-13 and IL-4 are produced during allergic responses and cause increases in airway epithelial cell mucus and electrolyte and water secretion into the airway surface liquid (ASL).	Water	144-149	heart and neural crest derivatives expressed 2	Mus musculus	4-7
18641360-2	2008	The Th2 cytokines IL-13 and IL-4 are produced during allergic responses and cause increases in airway epithelial cell mucus and electrolyte and water secretion into the airway surface liquid (ASL).	Water	144-149	interleukin 4	Mus musculus	28-32
18678353-1	2008	In the perspective of expanding the use of annexin A5 (anx A5) as radioactive tracer of cell death in vivo, we recently described its radiolabeling with (99m)Tc-tricarbonyl [(99m)Tc(H(2)O)(3)(CO)(3)](+) via the mercaptobutyrimidyl group (anx A5-SH).	Water	182-187	annexin A5	Homo sapiens	43-53
31938330-0	2018	miR-190 protects cardiomyocytes from apoptosis induced by H2O2 through targeting MAPK8 and regulating MAPK8/ERK signal pathway.	Water	58-62	mitogen-activated protein kinase 8	Rattus norvegicus	81-86
18678353-1	2008	In the perspective of expanding the use of annexin A5 (anx A5) as radioactive tracer of cell death in vivo, we recently described its radiolabeling with (99m)Tc-tricarbonyl [(99m)Tc(H(2)O)(3)(CO)(3)](+) via the mercaptobutyrimidyl group (anx A5-SH).	Water	182-187	annexin A5	Homo sapiens	55-61
18446469-7	2008	The low weight loss, low angles of contact and high water vapor transmission rate of PD-2 films were related to presence of higher concentration of PEG esters.	Water	52-57	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	85-89
19388360-13	2008	Moreover, brain water content was also significantly reduced paralleling the AQP4 suppression.	Water	16-21	aquaporin 4	Rattus norvegicus	77-81
19388360-14	2008	These data provide further support that vasopressin (AVP) and V1a receptors can control water flux through astrocytic plasma membranes by regulating AQP4 expression.	Water	88-93	aquaporin 4	Rattus norvegicus	149-153
31938330-0	2018	miR-190 protects cardiomyocytes from apoptosis induced by H2O2 through targeting MAPK8 and regulating MAPK8/ERK signal pathway.	Water	58-62	mitogen-activated protein kinase 8	Rattus norvegicus	102-107
18445132-9	2008	It is proposed that during PSII assembly AtCYP38 protein guides the proper folding of D1 (and CP43) into PSII, thereby enabling the correct assembly of the water-splitting Mn(4)-Ca cluster even with high turnover of PSII.	Water	156-161	cyclophilin 38	Arabidopsis thaliana	41-48
31938330-9	2018	In conclusion, these data suggest that miR-190 protects against oxidative stress injury of H9c2 cells induced by H2O2 through inhibiting MAPK8 expression and the MAPK8/ERK pathway.	Water	113-117	mitogen-activated protein kinase 8	Rattus norvegicus	137-142
31938330-9	2018	In conclusion, these data suggest that miR-190 protects against oxidative stress injury of H9c2 cells induced by H2O2 through inhibiting MAPK8 expression and the MAPK8/ERK pathway.	Water	113-117	mitogen-activated protein kinase 8	Rattus norvegicus	162-167
18521826-0	2008	Dissociation of amyloid fibrils of alpha-synuclein in supercooled water.	Water	66-71	synuclein alpha	Homo sapiens	35-50
29680529-1	2018	The Bohai Sea is characterized as a semi-closed sea with limited water exchange ability, which has been regarded as one of the most contaminated regions in China and has attracted public attention over the past decades.	Water	65-70	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	10-13
18847496-10	2008	Oral administration of either 5 mg/kg or 20 mg/kg STA-5326 reduced the severity of EAU on day 14 and 18.	Water	83-86	autosomal striping	Mus musculus	50-53
18847496-11	2008	In addition, mice treated with 20 mg/kg STA-5326 showed significantly decreased severity of EAU by histopathological analysis.	Water	92-95	autosomal striping	Mus musculus	40-43
18652671-4	2008	Extravascular lung water and mortality increased after alphaENaC and CFTR-silencing.	Water	19-24	CF transmembrane conductance regulator	Rattus norvegicus	69-73
29473308-0	2018	A Room-Temperature Postsynthetic Ligand Exchange Strategy to Construct Mesoporous Fe-Doped CoP Hollow Triangle Plate Arrays for Efficient Electrocatalytic Water Splitting.	Water	155-160	caspase recruitment domain family member 16	Homo sapiens	91-94
18576687-0	2008	Design and synthesis of glycosylated beta3-peptides capable of folding into the 3(14)-helical conformation in water.	Water	110-115	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	37-42
18449873-8	2008	Dissolution of the green complex [Cu2(ca)Cl2(HL1)2] resulted in the formation of new pink-purple mononuclear compound [Cu(ca)(HL1)(H2O)], the crystal structure of which was determined.	Water	131-135	intelectin 1	Homo sapiens	45-48
18449873-8	2008	Dissolution of the green complex [Cu2(ca)Cl2(HL1)2] resulted in the formation of new pink-purple mononuclear compound [Cu(ca)(HL1)(H2O)], the crystal structure of which was determined.	Water	131-135	intelectin 1	Homo sapiens	126-129
29473308-4	2018	As expected, the as-prepared mesoporous Fe-CoP HTPAs exhibit pronounced activity for water splitting owing to the advantages of abundant active reaction sites, short electron and ion pathways, and favorable hydrogen adsorption free energy (DeltaGH* ).	Water	85-90	caspase recruitment domain family member 16	Homo sapiens	43-46
29534012-0	2018	Ruthenium(eta6,eta1-arene-CH2-NHC) Catalysts for Direct Arylation of 2-Phenylpyridine with (Hetero)Aryl Chlorides in Water.	Water	117-122	secreted phosphoprotein 1	Homo sapiens	15-19
18401169-5	2008	We have employed both techniques to unravel the molecular machinery of vasopressin signaling, which governs water homeostasis by recruiting aquaporin-2 (AQP2) water channels after activation of the vasopressin-2 receptor by vasopressin.	Water	108-113	aquaporin 2	Homo sapiens	140-151
18401169-5	2008	We have employed both techniques to unravel the molecular machinery of vasopressin signaling, which governs water homeostasis by recruiting aquaporin-2 (AQP2) water channels after activation of the vasopressin-2 receptor by vasopressin.	Water	108-113	aquaporin 2	Homo sapiens	153-157
18536506-1	2008	Glyceryl ferulate was synthesized through condensation of ferulic acid and glycerol at 50 degrees C in glycerols with different water contents using an immobilized lipase from Candida antarctica in a batch reactor, and condensation in the glycerol with a 7.5% (w/w) water content was shown to be the favorite.	Water	128-133	PAN0_003d1715	Moesziomyces antarcticus	164-170
18464276-11	2008	In patients exposed to well water, a later age of onset was observed for those who carried at least one PARK2 380Leu allele.	Water	28-33	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	104-109
18558125-1	2008	Electrochemical impedance spectroscopy, ac voltammetry and fractal analysis were used to characterize model compounds, compound mixtures and extracted samples of sea surface microlayer (ssm) und underlying water (ulw).	Water	206-211	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	162-165
29534012-6	2018	The catalytic activity of [RuCl2(eta6,eta1-arene-CH2-NHC)] complexes was evaluated in the direct (hetero)arylation of 2-phenylpyridine with (hetero)aryl chlorides in water as the nontoxic reaction medium.	Water	166-171	secreted phosphoprotein 1	Homo sapiens	38-42
29965485-7	2018	There were mainly 55 species pathogenic bacteria in the water discharging into the sea.	Water	56-61	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	83-86
29331729-1	2018	Energies of CH/O interactions between water molecule and polycyclic aromatic hydrocarbons with a different number of aromatic rings were calculated using ab initio calculations at MP2/cc-PVTZ level.	Water	38-43	tryptase pseudogene 1	Homo sapiens	180-183
18394669-7	2008	Induction of the MTF1 responsive genes, metallothionein-A (MTA), metallothionein-B (MTB), and zinc transporter 1 (ZnT-1) in the cell culture was strongly dependent of the concentrations of bioreactive zinc and silver in the test water.	Water	229-234	zinc transporter 1a	Oncorhynchus mykiss	114-119
29474462-2	2018	Retinal Muller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels.	Water	30-35	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	100-106
18535720-1	2008	The Gaussian-type orbital and Gaussian-type geminal (GGn) model is applied to the water molecule, at the level of second-order Moller-Plesset (MP2) theory.	Water	82-87	tryptase pseudogene 1	Homo sapiens	143-146
18535720-3	2008	Optimizing the GG2 model using a weak-orthogonality functional, we obtain the current best estimate of the all-electron MP2 correlation energy of water, -361.95 mE(h).	Water	146-151	tryptase pseudogene 1	Homo sapiens	120-123
18535720-5	2008	For the barrier to linearity of water, we obtain an MP2 correlation contribution of -463 +/- 5 cm(-1).	Water	32-37	tryptase pseudogene 1	Homo sapiens	52-55
29341596-0	2018	Core-Shell ZIF-8@ZIF-67-Derived CoP Nanoparticle-Embedded N-Doped Carbon Nanotube Hollow Polyhedron for Efficient Overall Water Splitting.	Water	122-127	caspase recruitment domain family member 16	Homo sapiens	32-35
18491935-1	2008	Water intrusion-extrusion isotherms performed at room temperature on hydrophobic pure silica chabazite show that the water-Si-CHA system displays real spring behavior.	Water	0-5	transcription factor like 5	Homo sapiens	126-129
18491935-1	2008	Water intrusion-extrusion isotherms performed at room temperature on hydrophobic pure silica chabazite show that the water-Si-CHA system displays real spring behavior.	Water	117-122	transcription factor like 5	Homo sapiens	126-129
18491935-3	2008	(29)Si and especially (1)H solid-state NMR showed the creation of new defect sites upon the intrusion-extrusion of water and the existence of two kinds of water molecules trapped in the supercage of Si-CHA: a first layer of water strongly hydrogen bonded with the silanols of the framework and a subsequent layer of liquidlike physisorbed water molecules undergoing interaction with the first layer.	Water	155-160	transcription factor like 5	Homo sapiens	202-205
18491935-3	2008	(29)Si and especially (1)H solid-state NMR showed the creation of new defect sites upon the intrusion-extrusion of water and the existence of two kinds of water molecules trapped in the supercage of Si-CHA: a first layer of water strongly hydrogen bonded with the silanols of the framework and a subsequent layer of liquidlike physisorbed water molecules undergoing interaction with the first layer.	Water	155-160	transcription factor like 5	Homo sapiens	202-205
29341596-4	2018	When the CoP/NCNHP was employed as both the anode and cathode for overall water splitting, a potential as low as 1.64 V was needed to achieve the current density of 10 mA cm-2, and it still exhibited superior activity after continuously working for 36 h with nearly negligible decay in potential.	Water	74-79	caspase recruitment domain family member 16	Homo sapiens	9-12
18491935-3	2008	(29)Si and especially (1)H solid-state NMR showed the creation of new defect sites upon the intrusion-extrusion of water and the existence of two kinds of water molecules trapped in the supercage of Si-CHA: a first layer of water strongly hydrogen bonded with the silanols of the framework and a subsequent layer of liquidlike physisorbed water molecules undergoing interaction with the first layer.	Water	155-160	transcription factor like 5	Homo sapiens	202-205
29279115-6	2018	The modified electrode has been applied to the detection of Cd2+ and Pb2+ present in water and milk samples, and the accessed results were satisfactory with that of AAS.	Water	85-90	CD2 molecule	Homo sapiens	60-63
18367658-3	2008	It has been attributed to underexpression and mistargeting of aquaporin-2 (AQP2) water channel in the inner medullary collecting duct (IMCD).	Water	81-86	aquaporin 2	Rattus norvegicus	62-73
18367658-3	2008	It has been attributed to underexpression and mistargeting of aquaporin-2 (AQP2) water channel in the inner medullary collecting duct (IMCD).	Water	81-86	aquaporin 2	Rattus norvegicus	75-79
29179621-10	2018	The data support that the mechanisms involve preservation of the tight junction protein ZO-1 and the water channel AQP4, and indicate that treatment with EPO may have beneficial effects on the brain edema response following TBI.	Water	101-106	aquaporin 4	Rattus norvegicus	115-119
18315495-2	2008	Among the TRX superfamily is peroxiredoxin (PRX), a family of non-heme peroxidases that catalyzes the reduction of hydroperoxides into water and alcohol.	Water	135-140	thioredoxin	Homo sapiens	10-13
29179621-10	2018	The data support that the mechanisms involve preservation of the tight junction protein ZO-1 and the water channel AQP4, and indicate that treatment with EPO may have beneficial effects on the brain edema response following TBI.	Water	101-106	erythropoietin	Rattus norvegicus	154-157
29447195-7	2018	We found in open-water regions a significant negative relationship between sea surface temperature anomalies and phytoplankton biomass anomalies.	Water	17-22	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	75-78
18403144-4	2008	Pretreated with three dosages of PGR water extract (0.75, 1.5 and 3g/kg, po) for 5 days, male Wistar rats (220-240 g) were intoxicated by phenylisothiocyanate (PITC, 100mg/kg, po) 24h before probes intravenous injection.	Water	37-42	progesterone receptor	Rattus norvegicus	33-36
29447195-8	2018	This indicates that freshwater flow modification could alter the vertical stability of the water column throughout the Mediterranean Sea, by changing the strength of vertical mixing and consequently upper water fertilization.	Water	25-30	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	133-136
29447195-8	2018	This indicates that freshwater flow modification could alter the vertical stability of the water column throughout the Mediterranean Sea, by changing the strength of vertical mixing and consequently upper water fertilization.	Water	91-96	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	133-136
18414725-7	2008	Soot particles produced from laboratory flame of TC1 aviation kerosene are less hydrophobic, with their entire surface being available for statistical monolayer water coverage at RH approximately 10%.	Water	161-166	transcobalamin 1	Homo sapiens	49-52
18208539-4	2008	Following transient MCAO, brains of Egr1-/- mice showed less water accumulation and decreased neutrophil infiltration (by 42 +/- 8%, p &lt; 0.05) compared to Egr1+/+ mice.	Water	61-66	early growth response 1	Mus musculus	36-40
29435667-4	2018	These results indicated that Cd2+ and Zn2+ have a strong capacity to adsorb in the solid phase at the soil-water interface of boggy soil and yellow brown soil, respectively.	Water	107-112	CD2 molecule	Homo sapiens	29-32
18043939-0	2008	Test of blockers of AQP1 water permeability by a high-resolution method: no effects of tetraethylammonium ions or acetazolamide.	Water	25-30	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	20-24
18248592-1	2008	Catalase controls cellular H(2)O(2) and plays important roles in the adaptation of plants to various stresses, but little is known about the signaling events that lead to the expression of CAT1 and the production of H(2)O(2).	Water	27-32	catalase 2	Arabidopsis thaliana	0-8
18280225-2	2008	AQP1 and AQP5 expressed in lung provide the principal route for osmotically driven water transport.	Water	83-88	aquaporin 5	Homo sapiens	9-13
18280225-3	2008	In the airways, AQP3 and AQP4 facilitate water transport.	Water	41-46	aquaporin 3 (Gill blood group)	Homo sapiens	16-20
18370410-3	2008	Our kinetic and spectroscopic data for S167A indicate that this residue is not essential for O 2 or substrate binding, and we propose that hydrogen bond stabilization of the catalytic ferrous-oxy complex involves active site water molecules in IDO.	Water	225-230	indoleamine 2,3-dioxygenase 1	Homo sapiens	244-247
18238775-7	2008	Older animals aged 15-18 months showed progressive accumulation of human alpha-synuclein oligomers, associated with worse motor function and cognitive impairment in the Morris water maze.	Water	176-181	synuclein alpha	Homo sapiens	73-88
18336024-9	2008	In the presence of trace water, CN- hydrolysis yields HCN that reacts with Pd(0) to give [(CN)3PdH]2-.	Water	25-30	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	54-57
18365328-8	2008	In univariate analysis high versus low water price was positively associated with a high municipal incidence rate (odds ratio (OR) 1.9; 95% CI 1.5-2.6).	Water	39-44	olfactory receptor family 10 subfamily R member 3 pseudogene	Homo sapiens	115-134
18082251-1	2008	The purpose of this research was to investigate the potential causes of low oxygen levels in the bottom water of the Oyster Grounds region of the shallow southern North Sea, an area which provides suitable conditions for low oxygen levels to develop.	Water	104-109	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	169-172
18260680-4	2008	1H NMR studies revealed that POC16 and POC20 exist in the compact structure with the pyranine nucleus wrapped with a long methylene chain in water.	Water	141-146	ubiquitin like modifier activating enzyme 1	Homo sapiens	39-44
18278929-1	2008	In water, N-methyl-4-(p-substituted benzoyl)pyridinium cations, BP-X, exist in equilibrium with their hydrated forms (gem-diols), whose concentrations depend on the para substituent (-X).	Water	3-8	nucleosome assembly protein 1 like 2	Homo sapiens	64-68
18409627-6	2008	Calculated transition-state structures of NAC reduction intermediates were consistent with H2O elimination from substituted N,N-dihydroxyanilines as the predominant 15N-fractionating elementary reaction.	Water	91-94	synuclein alpha	Homo sapiens	42-45
17994554-5	2008	Here, the secondary structure of gamma-zein has been analyzed by circular dichroism in SDS aqueous solution with and without ditiothreitol (DTT), and in 60% of 2-propanol and water with DTT.	Water	175-180	prolamin 50 kDa gamma zein	Zea mays	33-43
17965749-7	2008	The prominent localization of IMD in hypothalamus and pituitary and in kidney is consistent with a physiological role in the central and peripheral regulation of the circulation and water-electrolyte homeostasis.	Water	182-187	adrenomedullin 2	Homo sapiens	30-33
18022180-0	2008	Easily prepared high-quantum-yield CdS quantum dots in water using hyperbranched polyethylenimine as modifier.	Water	55-60	CDP-diacylglycerol synthase 1	Homo sapiens	35-38
18022290-3	2008	Aquaporin-4 (AQP4) is the most abundant water channel in the brain.	Water	40-45	aquaporin 4	Rattus norvegicus	0-11
18022290-3	2008	Aquaporin-4 (AQP4) is the most abundant water channel in the brain.	Water	40-45	aquaporin 4	Rattus norvegicus	13-17
17965877-1	2008	To stimulate renal water reabsorption, vasopressin induces phosphorylation of Aquaporin-2 (AQP2) water channels at S256 and their redistribution from vesicles to the apical membrane, whereas vasopressin removal results in AQP2 ubiquitination at K270 and its internalization to multivesicular bodies (MVB).	Water	19-24	aquaporin 2	Canis lupus familiaris	78-89
17965877-1	2008	To stimulate renal water reabsorption, vasopressin induces phosphorylation of Aquaporin-2 (AQP2) water channels at S256 and their redistribution from vesicles to the apical membrane, whereas vasopressin removal results in AQP2 ubiquitination at K270 and its internalization to multivesicular bodies (MVB).	Water	19-24	aquaporin 2	Canis lupus familiaris	91-95
17965877-1	2008	To stimulate renal water reabsorption, vasopressin induces phosphorylation of Aquaporin-2 (AQP2) water channels at S256 and their redistribution from vesicles to the apical membrane, whereas vasopressin removal results in AQP2 ubiquitination at K270 and its internalization to multivesicular bodies (MVB).	Water	97-102	aquaporin 2	Canis lupus familiaris	78-89
17965877-1	2008	To stimulate renal water reabsorption, vasopressin induces phosphorylation of Aquaporin-2 (AQP2) water channels at S256 and their redistribution from vesicles to the apical membrane, whereas vasopressin removal results in AQP2 ubiquitination at K270 and its internalization to multivesicular bodies (MVB).	Water	97-102	aquaporin 2	Canis lupus familiaris	91-95
17965877-1	2008	To stimulate renal water reabsorption, vasopressin induces phosphorylation of Aquaporin-2 (AQP2) water channels at S256 and their redistribution from vesicles to the apical membrane, whereas vasopressin removal results in AQP2 ubiquitination at K270 and its internalization to multivesicular bodies (MVB).	Water	97-102	aquaporin 2	Canis lupus familiaris	222-226
18226521-5	2008	Using the new composite nanofiber mats as solid phase extraction materials, trace amount of propranolol (1 ng mL(-1)) in tap water can be easily detected after a simple sample preparation.	Water	125-130	filamin B	Homo sapiens	121-124
18247598-4	2008	Water cages with a 5(12)6(3) arrangement, which are improper to both sI and sII structures, are identified during the heterogeneous growth of sII methane hydrate.	Water	0-5	transcription elongation factor A1	Homo sapiens	76-79
18247598-4	2008	Water cages with a 5(12)6(3) arrangement, which are improper to both sI and sII structures, are identified during the heterogeneous growth of sII methane hydrate.	Water	0-5	transcription elongation factor A1	Homo sapiens	142-145
18287043-1	2008	By phosphoproteome analysis, we identified a phosphorylation site, serine 264 (pS264), in the COOH terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2).	Water	137-142	aquaporin 2	Mus musculus	165-169
18334804-4	2008	Vomiting and bulging fontanelle developed 3 months after admission, and CSF opening pressure was notably high at 430 mm/H2O.	Water	120-123	colony stimulating factor 2	Homo sapiens	72-75
18335805-3	2008	AQP2 is the predominant vasopressin regulated water channel of the kidney collecting duct and is essential for urinary concentration.	Water	46-51	aquaporin 2	Homo sapiens	0-4
18236022-29	2008	Water-restraint stress-induced R3 mRNA expression in the brain stem seems to support this hypothesis.	Water	0-5	relaxin 3	Rattus norvegicus	31-33
18589739-4	2008	The water extract of freeze-dried antler promoted the proliferation and IGF-I secretion of rat osteogenic-like cell UMR-106 by 245.25% ( MTT assay) and 66.36 ng/ml, which was respectively 2.2 times and 1.2 times of those of heating processed antler.	Water	4-9	insulin-like growth factor 1	Rattus norvegicus	72-77
18056644-8	2007	We suggest that the mechanism is a transient disturbance of the water cycle with a delayed response of land river runoff relative to ocean evaporation and global precipitation that affects global sea level.	Water	64-69	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	196-199
17806105-0	2007	High resolution q-space imaging studies of water in elastin.	Water	43-48	elastin	Bos taurus	52-59
17806105-1	2007	We report on the direct measurement of the molecular diffusion coefficients of water confined to purified bovine nuchal ligament elastin by high resolution q-space NMR imaging.	Water	79-84	elastin	Bos taurus	129-136
17806105-2	2007	The experimental data indicate that water trapped within an elastin fiber has two distinguishable molecular diffusion coefficients.	Water	36-41	elastin	Bos taurus	60-67
17806105-3	2007	The component with the slowest mobility has a diffusion coefficient on the order of 10(-6) cm(2)/s that varies inversely with the diffusion time and is seen to reduce near 37 degrees C. The component with higher mobility has a diffusion coefficient reminiscent of free water but is observed to also behave similarly at 37 degrees C. From our experimental data we extract the surface-to-volume ratio of pores within elastin and associated changes as a function of temperature.	Water	269-274	elastin	Bos taurus	415-422
17913832-0	2007	Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion.	Water	96-101	endothelin 1	Mus musculus	50-62
17913832-5	2007	During normal salt and water intake, urinary PGE(2) excretion was unexpectedly increased in CD ET-1 KO mice compared with controls.	Water	23-28	endothelin 1	Mus musculus	95-99
18247738-5	2007	These expressions indicate that the effect of the sea-water sound speed profile can be neglected for times greater than the peak intensity arrival.	Water	54-59	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	50-53
17989807-1	2007	We utilized the strategy of "borrowing SERS activity", by chemically coating several atomic layers of a Pt-group metal on highly SERS-active Au nanoparticles, to obtain the first SERS (also Raman) spectra of surface water on Pt and Pd metals, and propose conceptual models for water adsorbed on Pt and Pd metal surfaces.	Water	216-221	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	39-43
17989807-1	2007	We utilized the strategy of "borrowing SERS activity", by chemically coating several atomic layers of a Pt-group metal on highly SERS-active Au nanoparticles, to obtain the first SERS (also Raman) spectra of surface water on Pt and Pd metals, and propose conceptual models for water adsorbed on Pt and Pd metal surfaces.	Water	216-221	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	129-133
17989807-1	2007	We utilized the strategy of "borrowing SERS activity", by chemically coating several atomic layers of a Pt-group metal on highly SERS-active Au nanoparticles, to obtain the first SERS (also Raman) spectra of surface water on Pt and Pd metals, and propose conceptual models for water adsorbed on Pt and Pd metal surfaces.	Water	216-221	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	129-133
17989807-1	2007	We utilized the strategy of "borrowing SERS activity", by chemically coating several atomic layers of a Pt-group metal on highly SERS-active Au nanoparticles, to obtain the first SERS (also Raman) spectra of surface water on Pt and Pd metals, and propose conceptual models for water adsorbed on Pt and Pd metal surfaces.	Water	277-282	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	39-43
17940053-0	2007	MAL decreases the internalization of the aquaporin-2 water channel.	Water	53-58	aquaporin 2	Homo sapiens	41-52
17940053-1	2007	Body water homeostasis depends critically on the hormonally regulated trafficking of aquaporin-2 (AQP2) water channels in renal collecting duct epithelial cells.	Water	5-10	aquaporin 2	Homo sapiens	85-96
17940053-1	2007	Body water homeostasis depends critically on the hormonally regulated trafficking of aquaporin-2 (AQP2) water channels in renal collecting duct epithelial cells.	Water	5-10	aquaporin 2	Homo sapiens	98-102
17940053-1	2007	Body water homeostasis depends critically on the hormonally regulated trafficking of aquaporin-2 (AQP2) water channels in renal collecting duct epithelial cells.	Water	104-109	aquaporin 2	Homo sapiens	85-96
17940053-1	2007	Body water homeostasis depends critically on the hormonally regulated trafficking of aquaporin-2 (AQP2) water channels in renal collecting duct epithelial cells.	Water	104-109	aquaporin 2	Homo sapiens	98-102
17940053-8	2007	The S256-phosphorylated form of AQP2 appears to interact more extensively with MAL than does the water channel protein not phosphorylated at this serine.	Water	97-102	aquaporin 2	Homo sapiens	32-36
17724756-0	2007	The lipase-catalyzed hydrolysis of lutein diesters in non-aqueous media is favored at extremely low water activities.	Water	100-105	PAN0_003d1715	Moesziomyces antarcticus	4-10
18021062-0	2007	The oxygenase-peroxidase theory of Bach and Chodat and its modern equivalents: change and permanence in scientific thinking as shown by our understanding of the roles of water, peroxide, and oxygen in the functioning of redox enzymes.	Water	170-175	acyl-CoA thioesterase 7	Homo sapiens	35-39
17618150-6	2007	AQP1 may have a major osmoregulatory role in water transport in kidney and gut in SW-acclimated fish, whereas AQP3 could be implicated in gill water transport in FW-acclimated fish.	Water	143-148	aquaporin 3 (Gill blood group)	Homo sapiens	110-114
17952775-4	2007	Moreover, speciation of arsenicals in urine, and water-samples found in arsenobetaine (AsB).	Water	49-54	arylsulfatase B	Homo sapiens	87-90
29367999-2	2018	The as-prepared Ag2NCN NRs with a band gap of 2.35 eV are applied as photocatalysts for water oxidation.	Water	88-93	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	16-19
17970624-2	2007	Aquaporin-4 (AQP4) water channel is predominantly expressed by astrocytes and plays an important role in regulating water balance in the normal and injured brain.	Water	19-24	aquaporin 4	Rattus norvegicus	0-11
26620668-3	2008	The Quantum Chemical Topology (QCT) method yields the atomic multipole moments from a MP2/aug-cc-p-VTZ electron density of a single water molecule in the gas phase.	Water	132-137	tryptase pseudogene 1	Homo sapiens	86-89
18713446-5	2008	Water stress also induced increases in the activities of the chloroplastic and cytosolic anti-oxidant enzymes superoxide dismutase (SOD), ascorbate peroxidase (APX), and glutathione reductase (GR), and the increases in the activities of anti-oxidant enzymes were reduced by pretreatments with inhibitors of NOS and NR.	Water	0-5	glutathione reductase 1	Zea mays	170-191
17970624-2	2007	Aquaporin-4 (AQP4) water channel is predominantly expressed by astrocytes and plays an important role in regulating water balance in the normal and injured brain.	Water	19-24	aquaporin 4	Rattus norvegicus	13-17
18713446-5	2008	Water stress also induced increases in the activities of the chloroplastic and cytosolic anti-oxidant enzymes superoxide dismutase (SOD), ascorbate peroxidase (APX), and glutathione reductase (GR), and the increases in the activities of anti-oxidant enzymes were reduced by pretreatments with inhibitors of NOS and NR.	Water	0-5	glutathione reductase 1	Zea mays	193-195
18713446-5	2008	Water stress also induced increases in the activities of the chloroplastic and cytosolic anti-oxidant enzymes superoxide dismutase (SOD), ascorbate peroxidase (APX), and glutathione reductase (GR), and the increases in the activities of anti-oxidant enzymes were reduced by pretreatments with inhibitors of NOS and NR.	Water	0-5	nitrate reductase [NADH] 1	Zea mays	315-317
17970624-2	2007	Aquaporin-4 (AQP4) water channel is predominantly expressed by astrocytes and plays an important role in regulating water balance in the normal and injured brain.	Water	116-121	aquaporin 4	Rattus norvegicus	0-11
17970624-2	2007	Aquaporin-4 (AQP4) water channel is predominantly expressed by astrocytes and plays an important role in regulating water balance in the normal and injured brain.	Water	116-121	aquaporin 4	Rattus norvegicus	13-17
29254034-1	2018	The water-soluble exopolysaccharide REPS2-A was isolated and characterized from R. mucilaginosa CICC 33013.	Water	4-9	RALBP1 associated Eps domain containing 2	Homo sapiens	36-41
28954306-7	2018	The serum VEGF level was negatively correlated with the sciatic NCV (r=-0.932, P&lt;0.01) and positively correlated with the tail flick threshold temperature (r=0.835, P&lt;0.01) as well as the water content of the sciatic nerve (r=0.901, P&lt;0.01).	Water	194-199	vascular endothelial growth factor A	Rattus norvegicus	10-14
17265424-2	2007	It has been proposed that this increase in ADC generally results from an increase in the tumor extracellular volume fraction leading to a greater degree of unrestricted water motion.	Water	169-174	antizyme inhibitor 2	Homo sapiens	43-46
18190191-3	2008	The purely ab initio CC-pol and HBB potentials that were previously shown to yield very accurate water dimer levels, also reproduce the trimer levels well when supplemented with an appropriate three-body interaction potential.	Water	97-102	hemoglobin subunit beta	Homo sapiens	32-35
29478644-2	2018	Major regulations in different countries and regions identify chemicals according to their bioconcentration factor (BCF) and octanol-water partition coefficient (Kow), which frequently displays a substantial correlation with the sediment sorption coefficient (Koc).	Water	133-138	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	260-263
18209476-10	2008	The expression of aquaporin 2 (AQP2) water channel, exclusively present in principal cells of the collecting duct, was comparable in the wild type and CAR2-null mice.	Water	37-42	aquaporin 2	Mus musculus	18-29
17764178-5	2007	Recent experimental results suggest that this transfer occurs through water molecules, a phenomenon which has been theoretically evidenced to be of high efficiency in the case of cytochrome b5 (Science, 2005, 310, 1311).	Water	70-75	cytochrome b5 type A	Homo sapiens	179-192
18209476-10	2008	The expression of aquaporin 2 (AQP2) water channel, exclusively present in principal cells of the collecting duct, was comparable in the wild type and CAR2-null mice.	Water	37-42	aquaporin 2	Mus musculus	31-35
28401489-6	2018	In addition, the expression of CXCR3 and CXCL10 was increased in the spinal cord in the dry skin model induced by acetone and diethyl ether followed by water (AEW).	Water	152-157	chemokine (C-X-C motif) receptor 3	Mus musculus	31-36
17881564-2	2007	We show here that expression of the Arabidopsis HARDY (HRD) gene in rice improves water use efficiency, the ratio of biomass produced to the water used, by enhancing photosynthetic assimilation and reducing transpiration.	Water	82-87	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	48-53
17881564-2	2007	We show here that expression of the Arabidopsis HARDY (HRD) gene in rice improves water use efficiency, the ratio of biomass produced to the water used, by enhancing photosynthetic assimilation and reducing transpiration.	Water	82-87	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	55-58
17881564-2	2007	We show here that expression of the Arabidopsis HARDY (HRD) gene in rice improves water use efficiency, the ratio of biomass produced to the water used, by enhancing photosynthetic assimilation and reducing transpiration.	Water	141-146	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	48-53
17881564-2	2007	We show here that expression of the Arabidopsis HARDY (HRD) gene in rice improves water use efficiency, the ratio of biomass produced to the water used, by enhancing photosynthetic assimilation and reducing transpiration.	Water	141-146	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	55-58
18433796-4	2008	The structure of the water circulation was not well understood during the planning of Sellafield nuclear plant outfall site in the eastern Irish Sea.	Water	21-26	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	145-148
29223068-2	2018	As an antioxidant enzyme, catalase converts hydrogen peroxide to water and keeps ROS level down to protect cells from stress-induced apoptosis.	Water	65-70	catalase 2	Arabidopsis thaliana	26-34
18421228-3	2008	We could also elaborate several differences between EAU induced with S-antigen peptide PDSAg or R14, a peptide derived from interphotoreceptor retinoid-binding protein, suggesting two differently regulated diseases in the same rat strain.	Water	52-55	S-antigen visual arrestin	Rattus norvegicus	69-78
17705397-0	2007	A water-soluble "switching on" fluorescent chemosensor of selectivity to Cd2+.	Water	2-7	CD2 molecule	Homo sapiens	73-76
29153877-5	2018	The results show that PHMOC (300-470 mug C L-1) was approximately 10% of the TOC in the surface water and was removed to 50-100 mug C L-1.	Water	96-101	adhesion G protein-coupled receptor L1	Homo sapiens	41-46
17626240-2	2007	AVP induces the insertion of the water channel aquaporin-2 (AQP2) into the plasma membrane of principal cells, thereby increasing the osmotic water permeability.	Water	33-38	aquaporin 2	Rattus norvegicus	47-58
18655907-2	2008	The mechanisms for these defects predominantly involve the non-osmotic stimulation of arginine vasopressin release with upregulation of aquaporin 2 water channel expression and trafficking to the apical membrane of the principal cells of the collecting duct.	Water	148-153	aquaporin 2	Homo sapiens	136-147
18655910-2	2008	This large increase in water permeability is largely due to the translocation of the water channel aquaporin-2 (AQP-2) from intracellular storage vesicles to the apical plasma membrane of collecting duct principal cells.	Water	23-28	aquaporin 2	Homo sapiens	85-110
18655910-2	2008	This large increase in water permeability is largely due to the translocation of the water channel aquaporin-2 (AQP-2) from intracellular storage vesicles to the apical plasma membrane of collecting duct principal cells.	Water	23-28	aquaporin 2	Homo sapiens	112-117
17626240-2	2007	AVP induces the insertion of the water channel aquaporin-2 (AQP2) into the plasma membrane of principal cells, thereby increasing the osmotic water permeability.	Water	33-38	aquaporin 2	Rattus norvegicus	60-64
29161662-6	2018	During the chloramination of IPM-containing water, CHCl2I and iodoacetic acid were the predominant iodinated trihalomethanes (I-THMs) and iodinated haloacetic acids (I-HAAs), respectively in the absence of ZVI, while CHI3 and triiodoacetic acid became the predominant ones with 1.0 g L-1 ZVI.	Water	44-49	chitinase 1	Homo sapiens	217-221
17626240-2	2007	AVP induces the insertion of the water channel aquaporin-2 (AQP2) into the plasma membrane of principal cells, thereby increasing the osmotic water permeability.	Water	142-147	aquaporin 2	Rattus norvegicus	47-58
17626240-2	2007	AVP induces the insertion of the water channel aquaporin-2 (AQP2) into the plasma membrane of principal cells, thereby increasing the osmotic water permeability.	Water	142-147	aquaporin 2	Rattus norvegicus	60-64
17626240-10	2007	Collectively, the data indicate that microtubule-dependent transport of AQP2 is predominantly responsible for trafficking and localization of AQP2 inside the cell after its internalization but not for the exocytic transport of the water channel.	Water	231-236	aquaporin 2	Rattus norvegicus	72-76
17171245-3	2007	These analyses show that the area in general is characterized by hard water and high salinity hazard, possibly due to its proximity and hydraulic connection with the sea.	Water	70-75	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	166-169
17888935-8	2007	The distinct coagulation feature of Al(a), Al(b), and Al(c) can be applied to develop tailor-made PACl (with the correct distribution of Al species) to match the characteristics of raw water for optimized coagulation.	Water	185-190	allantoicase	Homo sapiens	54-59
29600629-12	2018	So the pathway of AVP-V2R-AQP2 may be one of the mechanism for which Zhenwu Tang regulate balance of water transportation.	Water	101-106	aquaporin 2	Rattus norvegicus	26-30
17713901-2	2007	In the present paper, eight Molecular Dynamics (MD) simulations are carried out to examine the importance of structure and dynamics of water in the active site of both CDK2 and CDK5 complexes with roscovitine and indirubin analogues.	Water	135-140	cyclin dependent kinase 5	Homo sapiens	177-181
29381136-2	2018	The conserved mitochondrial-encoded COX1- and COX2-subunits are the heme- and copper-center containing core subunits that catalyze water formation.	Water	131-136	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	36-40
17713901-3	2007	Together with previous results, the current work shows a highly conserved water-involved hydrogen bonding (HB) network in both CDK2- and CDK5-indirubin combinations to complete information from the X-ray crystallography.	Water	74-79	cyclin dependent kinase 5	Homo sapiens	137-141
29370749-6	2018	Water-maze testing showed an improved cognitive function of the Tg6799 mice treated with clusterin.	Water	0-5	clusterin	Mus musculus	89-98
17676861-1	2007	An efficient synthesis of Pd nanoparticles in water has been developed using a Fischer carbene complex of tungsten as the reductant and PEG as the capping agent.	Water	46-51	progestagen associated endometrial protein	Homo sapiens	136-139
29292995-1	2018	Interaction between p-toluenesulfonic acid (pTSA) and water is studied at -20  C in a CCl4 matrix.	Water	54-59	C-C motif chemokine ligand 4	Homo sapiens	86-90
17459468-0	2007	Water-soluble chitosan-based antisense oligodeoxynucleotide of interleukin-5 for treatment of allergic rhinitis.	Water	0-5	interleukin 5	Mus musculus	63-76
17459468-2	2007	To inhibit the production of IL-5, water-soluble chitosan (WSC)-based IL-5 antisense oligodeoxynucleotide (AS-ODN) complex was generated.	Water	35-40	interleukin 5	Mus musculus	29-33
17459468-2	2007	To inhibit the production of IL-5, water-soluble chitosan (WSC)-based IL-5 antisense oligodeoxynucleotide (AS-ODN) complex was generated.	Water	35-40	interleukin 5	Mus musculus	70-74
29292995-2	2018	In CCl4 water exists as monomers with restricted rotational motion about its symmetry axis.	Water	8-13	C-C motif chemokine ligand 4	Homo sapiens	3-7
29292995-3	2018	Additionally, CCl4 is transparent in the hydrogen-bonded region; CCl4 thus constitutes an excellent ambient thermal energy matrix isolation medium for diagnosing interactions with water.	Water	180-185	C-C motif chemokine ligand 4	Homo sapiens	14-18
29292995-3	2018	Additionally, CCl4 is transparent in the hydrogen-bonded region; CCl4 thus constitutes an excellent ambient thermal energy matrix isolation medium for diagnosing interactions with water.	Water	180-185	C-C motif chemokine ligand 4	Homo sapiens	65-69
29292995-5	2018	In addition, negative monomer symmetric and asymmetric stretch features relative to nominally dry CCl4 indicate that fewer water monomers exist in the cooled (-20  C) acid solution than in room-temperature anhydrous CCl4.	Water	123-128	C-C motif chemokine ligand 4	Homo sapiens	216-220
29292995-9	2018	The coexistence of these two species provides insights into interactions in this acid-water CCl4 system.	Water	86-91	C-C motif chemokine ligand 4	Homo sapiens	92-96
17607730-7	2007	Several factors could influence the effect of perchlorate exposure on NIS and pendrin gene expression in the stomach and kidney, including (1) pre-exposure to trace perchlorate through food and water perhaps resulting in adaptation (or tolerance) in these animals; (2) metabolism of perchlorate in deer mice causing only 46-61% perchlorate excreted into urine.	Water	194-199	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	70-73
28864207-0	2018	Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats.	Water	89-94	relaxin 3	Rattus norvegicus	50-59
17652763-1	2007	PURPOSE: Cellular retinaldehyde-binding protein (CRALBP), transcribed from the RLBP1 gene, is a 36-kDa water-soluble protein with 316 amino acids found in the retinal pigment epithelium (RPE) and in retinal Muller cells.	Water	103-108	retinaldehyde binding protein 1	Homo sapiens	49-55
17652763-1	2007	PURPOSE: Cellular retinaldehyde-binding protein (CRALBP), transcribed from the RLBP1 gene, is a 36-kDa water-soluble protein with 316 amino acids found in the retinal pigment epithelium (RPE) and in retinal Muller cells.	Water	103-108	retinaldehyde binding protein 1	Homo sapiens	79-84
28864207-2	2018	Intracerebroventricular (icv) administration of RLN3 in rats strongly increases food and water intake and alters the activity of the hypothalamic-pituitary-adrenal (HPA) and gonadal (HPG) axes, but the relative involvement of RXFP3 and RXFP1 in these effects is not known.	Water	89-94	relaxin 3	Rattus norvegicus	48-52
28864207-5	2018	Water intake and plasma corticosterone and testosterone levels were significantly increased by RLN3, but not by RXFP3-A2.	Water	0-5	relaxin 3	Rattus norvegicus	95-99
28864207-9	2018	These results suggest that RXFP1 is involved in the RLN3 stimulation of water intake and activation of the HPA and HPG axes.	Water	72-77	relaxin 3	Rattus norvegicus	52-56
29330496-0	2018	Framing Continental Shelf Waves in the southern Adriatic Sea, a further flushing factor beyond dense water cascading.	Water	101-106	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	57-60
17578632-2	2007	Intercellular gap junction channels, formed by at least three different connexin protein subunits, alpha1 (connexin43 or Gja1), alpha3 (connexin46 or Gja3) and alpha8 (connexin50 or Gja8), are utilized to transport metabolites, ions and water in the lens.	Water	237-242	gap junction protein alpha 3	Homo sapiens	136-146
29330496-5	2018	This signal appears as a persistent feature triggered by the inflow of a dense water vein formed in the northern Adriatic Sea, propagating upwelling and downwelling patterns along broad sectors of the continental slope.	Water	79-84	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	122-125
17521807-2	2007	Initial experiments revealed that the direct photolysis of 2,4-DNT in deionized water solutions under sunlight and artificial light followed a pseudo-first order kinetic.	Water	80-85	5', 3'-nucleotidase, cytosolic	Homo sapiens	63-66
29310592-10	2018	CONCLUSION: This study has shown the isolation of NTM species from humans and water.	Water	78-83	neurotrimin	Homo sapiens	50-53
17521807-4	2007	The presence of salt (NaCl) in the deionized water solutions was found to have a more pronounced sensitizing effect upon the photolysis of 2,4-DNT, yielding half lives of the order of 1h.	Water	45-50	5', 3'-nucleotidase, cytosolic	Homo sapiens	143-146
17521807-5	2007	Investigations on seawater and groundwater spiked with 2,4-DNT, revealed that photolysis is enhanced in the order seawater &gt; groundwater approximately deionized water.	Water	21-26	5', 3'-nucleotidase, cytosolic	Homo sapiens	59-62
17622411-10	2007	We also simulated chloroform/cs3/water ternary systems, showing that the modifiers are surface active and stabilize the formation of water nanodroplets, while other modifier molecules drag some water to the organic phase.	Water	133-138	myozenin 3	Homo sapiens	29-32
17622411-10	2007	We also simulated chloroform/cs3/water ternary systems, showing that the modifiers are surface active and stabilize the formation of water nanodroplets, while other modifier molecules drag some water to the organic phase.	Water	133-138	myozenin 3	Homo sapiens	29-32
29301341-7	2018	Subsequently, we found AQP1 and AQP3 to be the most predominant AQPs accounting for water and glycerol fluxes, respectively, in the healthy endothelium.	Water	84-89	aquaporin 3 (Gill blood group)	Homo sapiens	32-36
17522053-0	2007	Aquaporin-1 channel function is positively regulated by protein kinase C. Aquaporin-1 (AQP1) channels contribute to osmotically induced water transport in several organs including the kidney and serosal membranes such as the peritoneum and the pleura.	Water	136-141	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	0-11
17522053-0	2007	Aquaporin-1 channel function is positively regulated by protein kinase C. Aquaporin-1 (AQP1) channels contribute to osmotically induced water transport in several organs including the kidney and serosal membranes such as the peritoneum and the pleura.	Water	136-141	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	74-85
17522053-0	2007	Aquaporin-1 channel function is positively regulated by protein kinase C. Aquaporin-1 (AQP1) channels contribute to osmotically induced water transport in several organs including the kidney and serosal membranes such as the peritoneum and the pleura.	Water	136-141	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	87-91
17522053-5	2007	Activation of protein kinase C (PKC) by 1-oleoyl-2-acetyl-sn-glycerol (OAG) induced a marked increase of AQP1-dependent water permeability.	Water	120-125	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	105-109
29433394-12	2018	These results indicate that the W-EA fraction from water extract of D. morbifera leaves enhances IL-2 production at the transcriptional levels via the up-regulation of NF-AT in PMA/Io-activated EL-4 T cells.	Water	51-56	interleukin 2	Mus musculus	97-101
17502149-1	2007	Four novel water-soluble peptide-paclitaxel conjugates were designed and synthesized as prostate-specific antigen (PSA)-activated prodrugs for prostate cancer therapy.	Water	11-16	kallikrein related peptidase 3	Homo sapiens	88-120
29046292-1	2018	The urea channel UT-A1 and the water channel aquaporin-2 (AQP2) mediate vasopressin-regulated transport in the renal inner medullary collecting duct (IMCD).	Water	31-36	aquaporin 2	Rattus norvegicus	58-62
17553491-7	2007	We further show that aquaporin 5 expression, a water channel localized within the apical membrane of epithelial cells, is completely abolished in the presence of the cytokine.	Water	47-52	aquaporin 5	Homo sapiens	21-32
17592591-0	2007	Synthesis, complexation and water exchange properties of Gd(III)-TTDA-mono and bis(amide) derivatives and their binding affinity to human serum albumin.	Water	28-33	general transcription factor IIH subunit 5	Homo sapiens	65-69
17466972-0	2007	Urine osmolality, cyclic AMP and aquaporin-2 in urine of patients under lithium treatment in response to water loading followed by vasopressin administration.	Water	105-110	aquaporin 2	Homo sapiens	33-44
17765649-3	2007	Affinity immunoprecipitation was used to identify a novel ligand for CD62L from a water extract from AFA.	Water	82-87	selectin L	Homo sapiens	69-74
17765649-4	2007	The effects of AFA water extract on CD62L binding and CXCR4 expression was tested in vitro using human bone marrow CD34+ cells and the two progenitor cell lines, KG1a and K562.	Water	19-24	selectin L	Homo sapiens	36-41
17765649-9	2007	CONCLUSION: AFA water extract contains a novel ligand for CD62L.	Water	16-21	selectin L	Homo sapiens	58-63
17524381-18	2007	The L(alpha)/NL phase transition temperatures are also higher in the rac-beta-D-GalDAGs than in the corresponding rac-beta-D-GlcDAGs, suggesting that the orientation of the hydroxyl at position 4 and the chirality of the glycerol molecule in the lipid/water interface influence both the L(c) and NL phase properties of these lipids, probably by controlling the relative positions of hydrogen bond donors and acceptors in the polar region of the membrane.	Water	252-257	AKT serine/threonine kinase 2	Homo sapiens	69-77
17318528-9	2007	The binding of the mimotopes to the Fab part of the IgG1 antibody and binding of SpA to the Fc part of the IgG1 antibody were mainly driven by hydrophobic effects and associated with a relatively large change in water-accessible surface area.	Water	212-217	FA complementation group B	Homo sapiens	36-39
17437301-10	2007	The different roles of AQP4 during HI and reoxygenation suggest that AQP4 knockdown may protect against water influx in the formation of astrocyte swelling during HI, and may also delay water clearance in the resolution of astrocyte swelling during reoxygenation.	Water	104-109	aquaporin 4	Rattus norvegicus	69-73
17437301-10	2007	The different roles of AQP4 during HI and reoxygenation suggest that AQP4 knockdown may protect against water influx in the formation of astrocyte swelling during HI, and may also delay water clearance in the resolution of astrocyte swelling during reoxygenation.	Water	186-191	aquaporin 4	Rattus norvegicus	69-73
17437301-11	2007	In conclusion, AQP4 mediates bidirectional transport of water across astrocytes during HI and reoxygenation.	Water	56-61	aquaporin 4	Rattus norvegicus	15-19
17510212-2	2007	In the kidney, chloride channels CLC-Ka (gene CLCNKA) and CLC-Kb (gene CLCNKB) and their subunit Barttin (gene BSND) have important effects on the control of Na(+) and water homeostasis.	Water	168-173	barttin CLCNK type accessory subunit beta	Homo sapiens	97-104
17510212-2	2007	In the kidney, chloride channels CLC-Ka (gene CLCNKA) and CLC-Kb (gene CLCNKB) and their subunit Barttin (gene BSND) have important effects on the control of Na(+) and water homeostasis.	Water	168-173	barttin CLCNK type accessory subunit beta	Homo sapiens	111-115
26633207-3	2007	We illustrate this here by calculating accurate Moller-Plesset second-order perturbation theory (MP2) energies for a series of clusters ranging in size from 5 to 20 water molecules.	Water	165-170	tryptase pseudogene 1	Homo sapiens	97-100
17243152-4	2007	NWPF discs were partially hydrolyzed, and then the carboxyl groups were coupled with leukemia inhibitory factor (LIF) in the presence of water-soluble carbodiimide.	Water	137-142	leukemia inhibitory factor	Mus musculus	85-111
17243152-4	2007	NWPF discs were partially hydrolyzed, and then the carboxyl groups were coupled with leukemia inhibitory factor (LIF) in the presence of water-soluble carbodiimide.	Water	137-142	leukemia inhibitory factor	Mus musculus	113-116
17469852-4	2007	Some anticatalytic mutations in DHFR also increase the distance between the donor and acceptor, but this effect is not directly related to catalysis since the native enzyme and the uncatalyzed reaction in water have similar average donor-acceptor distances.	Water	205-210	dihydrofolate reductase	Homo sapiens	32-36
17507561-3	2007	The intracerebroventricular injection of Abeta(1-40) in mice resulted in marked deficits of learning and memory, according to assessment in the water maze paradigm.	Water	144-149	amyloid beta (A4) precursor protein	Mus musculus	41-46
17419618-2	2007	Variable-temperature (5-25 degrees C) and variable-pressure (10-130 MPa) kinetics studies have yielded the activation parameters for the combined protonation/isomerization process (k-2/Ka1) from Cp*MoO2(OH) to [Cp*MoO2(H2O)]+, viz., DeltaH++= 5.1 +/- 0.1 kcal mol-1, DeltaS++ = -37 +/- 1 cal mol-1 K-1, and DeltaV++ = -9.1 +/- 0.2 cm3 mol-1.	Water	219-222	glutamate ionotropic receptor kainate type subunit 4	Homo sapiens	185-188
17428749-2	2007	The pure enzyme reacted positively with anti-LMW-PTP antibody, displayed tyrosine-specific phosphatase activity and was extremely sensitive to H(2)O(2).	Water	143-148	acid phosphatase 1, soluble	Mus musculus	45-52
17341486-4	2007	We find that Rcan1(-/-) neurons display an increased resistance to damage by H(2)O(2), which can be reverted by RCAN1 overexpression or by exogenous inhibitors of calcineurin.	Water	77-83	regulator of calcineurin 1	Homo sapiens	13-18
17341486-4	2007	We find that Rcan1(-/-) neurons display an increased resistance to damage by H(2)O(2), which can be reverted by RCAN1 overexpression or by exogenous inhibitors of calcineurin.	Water	77-83	regulator of calcineurin 1	Homo sapiens	112-117
26627435-3	2007	The revised implicit solvent model (ISM-2) for the simulation of cationic surfactants in water was proposed in the previous study (J. Phys.	Water	89-94	isthmin 2	Homo sapiens	36-41
17430051-0	2007	Molecular mechanism of transporting a polarizable iodide anion across the water-CCl4 liquid/liquid interface.	Water	74-79	C-C motif chemokine ligand 4	Homo sapiens	80-84
17430051-1	2007	The result of transferring a polarizable iodide anion across the H2O-CCl4 liquid/liquid interface was investigated in this study.	Water	65-68	C-C motif chemokine ligand 4	Homo sapiens	69-73
17430051-4	2007	Molecular dynamics simulations were also carried out to compare the concentrations of NaCl, NaBr, and NaI at the H2O-vapor and H2O-CCl4 interfaces.	Water	127-130	C-C motif chemokine ligand 4	Homo sapiens	131-135
17430051-5	2007	While the concentration of bromide and iodide ions were lower at the H2O-CCl4 interface when compared to the H2O-vapor interface, the chloride ion concentrations were similar at both interfaces.	Water	69-72	C-C motif chemokine ligand 4	Homo sapiens	73-77
17628981-11	2007	CONCLUSIONS: (1) AF, AQP1 and AQP2 have its individual specific localization in the rat inner ear, which was close to the parts of endolymph, so regulating water of the endolymph may be possible.	Water	156-161	aquaporin 2	Rattus norvegicus	30-34
17388441-3	2007	Structural alteration of the protein was observed in native myoglobin glycerol solution and native myoglobin water solution.	Water	109-114	myoglobin	Homo sapiens	99-108
17388441-11	2007	Thermal collisions form the dominant energy transfer pathway for modified myoglobin in water solution, and for both native myoglobin and modified myoglobin in a nonpolar environment.	Water	87-92	myoglobin	Homo sapiens	74-83
17300195-2	2007	In the context of the HoxD9 homeodomain bound specifically to DNA we were able to directly observe three cross-peaks, arising from lysine NH3 groups, with 15N chemical shifts around approximately 33 ppm at pH 5.8 and 35 degrees C. Measurement of water-exchange rates and various types of 15N transverse relaxation rates for these NH3 groups, reveals that rapid water exchange dominates the 15N relaxation for antiphase coherence with respect to 1H through scalar relaxation of the second kind.	Water	246-251	homeobox D9	Homo sapiens	22-27
17300195-2	2007	In the context of the HoxD9 homeodomain bound specifically to DNA we were able to directly observe three cross-peaks, arising from lysine NH3 groups, with 15N chemical shifts around approximately 33 ppm at pH 5.8 and 35 degrees C. Measurement of water-exchange rates and various types of 15N transverse relaxation rates for these NH3 groups, reveals that rapid water exchange dominates the 15N relaxation for antiphase coherence with respect to 1H through scalar relaxation of the second kind.	Water	361-366	homeobox D9	Homo sapiens	22-27
17719596-1	2007	Amphiphilic colloids of CdS and noble metal nanoparticles, which can be dispersed both in water and organic solvents such as ethanol, N,N-dimethylformamide, chloroform, and toluene, are studied.	Water	90-95	CDP-diacylglycerol synthase 1	Homo sapiens	24-27
17972915-6	2007	Erv1 also utilized molecular oxygen as an electron acceptor to generate hydrogen peroxide, which is subsequently reduced to water by cytochrome c peroxidase (Ccp1).	Water	124-129	growth factor, augmenter of liver regeneration	Homo sapiens	0-4
17972915-6	2007	Erv1 also utilized molecular oxygen as an electron acceptor to generate hydrogen peroxide, which is subsequently reduced to water by cytochrome c peroxidase (Ccp1).	Water	124-129	coiled-coil domain containing 115	Homo sapiens	158-162
17948990-3	2007	The structure of [Cd3(H2O)3((O3PCH2)2NH-CH2C6H4-COOH)2].11H2O is built up of cadmium phosphonate layers connected by water-mediated hydrogen bonds between aryl-carboxylic acid groups and water molecules coordinated to Cd2+ ions of adjacent layers (C-OH...H2O...H2O-Cd2+).	Water	22-25	CD2 molecule	Homo sapiens	218-221
17948990-3	2007	The structure of [Cd3(H2O)3((O3PCH2)2NH-CH2C6H4-COOH)2].11H2O is built up of cadmium phosphonate layers connected by water-mediated hydrogen bonds between aryl-carboxylic acid groups and water molecules coordinated to Cd2+ ions of adjacent layers (C-OH...H2O...H2O-Cd2+).	Water	22-25	CD2 molecule	Homo sapiens	265-268
17948990-3	2007	The structure of [Cd3(H2O)3((O3PCH2)2NH-CH2C6H4-COOH)2].11H2O is built up of cadmium phosphonate layers connected by water-mediated hydrogen bonds between aryl-carboxylic acid groups and water molecules coordinated to Cd2+ ions of adjacent layers (C-OH...H2O...H2O-Cd2+).	Water	58-61	CD2 molecule	Homo sapiens	218-221
17948990-3	2007	The structure of [Cd3(H2O)3((O3PCH2)2NH-CH2C6H4-COOH)2].11H2O is built up of cadmium phosphonate layers connected by water-mediated hydrogen bonds between aryl-carboxylic acid groups and water molecules coordinated to Cd2+ ions of adjacent layers (C-OH...H2O...H2O-Cd2+).	Water	58-61	CD2 molecule	Homo sapiens	265-268
19675716-3	2007	As devices emitting longer wavelengths are widely used in therapeutic and cosmetic interventions and as the induction of MMP-1 by water-filtered infrared-A (wIRA) had been discussed, it was of interest to assess effects of wIRA on the cellular and molecular level known to be possibly involved in cutaneous degeneration.	Water	130-135	matrix metallopeptidase 1	Homo sapiens	121-126
19675716-4	2007	OBJECTIVES: Investigation of the biological implications of widely used water-filtered infrared-A (wIRA) radiators for clinical use on human skin fibroblasts assessed by MMP-1 gene expression (MMP-1 messenger ribonucleic acid (mRNA) expression).	Water	72-77	matrix metallopeptidase 1	Homo sapiens	170-175
17699554-1	2007	The canonical transient receptor potential channels TRPC3 and TRPC6 are abundantly expressed along with the water channel aquaporin-2 (AQP2) in principal cells of the cortical and medullary collecting duct.	Water	108-113	aquaporin 2	Rattus norvegicus	135-139
17927670-4	2007	Microarray studies on mRNAs differentially expressed in the SON revealed that transcripts encoding the Ywhag and Ywhaz isoforms of the 14-3-3 family of regulatory proteins, are increased in the rat SON by 3 days of water deprivation; findings that we have confirmed by the real-time polymerase chain reaction.	Water	215-220	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta	Rattus norvegicus	113-118
17700641-6	2007	These renal responses were associated with significant decreases in AQP1 and AQP2 water channel expression in both the ad lib and paired intake studies in the cortex and inner medulla.	Water	82-87	aquaporin 2	Rattus norvegicus	77-81
18075463-2	2007	An evidence exists that PTK2B is involved in cell growth, vascular contraction, inflammatory responses, and salt and water retention through activation of the angiotensin II type 1 receptor.	Water	117-122	protein tyrosine kinase 2 beta	Homo sapiens	24-29
17720812-3	2007	We used 4-nitrobenzo-2-oxa-1,3-diazole to identify a cysteine sulfenic acid (Cys-SOH) modification that forms on Cys(36) of Orp1(Cys36) upon exposure to H(2)O(2).	Water	153-158	peroxiredoxin HYR1	Saccharomyces cerevisiae S288C	124-128
17761668-6	2007	Collectively, these findings demonstrate that the oxidant emitting potential of mitochondria is increased in skeletal muscle during recovery from exercise, possibly as a consequence of prolonged reliance on lipid metabolism and/or altered mitochondrial biochemistry/morphology and that induction of UCP3 in vivo mediates an increase in uncoupling activity that restores mitochondrial H(2)O(2) emission to non-exercised, control levels.	Water	384-389	uncoupling protein 3	Rattus norvegicus	299-303
18064936-5	2007	During a fall from a jet ski at high speeds, the water behaves as a solid object that penetrates the body.	Water	49-54	SKI proto-oncogene	Homo sapiens	25-28
17291025-8	2007	Cd2+ shows a lesser diffusion coefficient compared to that of Pb2+ despite its smaller atomic radius, indicating a more persistent first coordination shell for the cadmium(II) ion, a result confirmed with calculations of the mean residence time of water molecules in the first coordination shell.	Water	248-253	CD2 molecule	Homo sapiens	0-3
16765044-5	2007	The polluted water contaminated with an individual dye or mixtures of dyes treated with soluble and immobilized potato polyphenol oxidase resulted in the remarkable loss in total organic carbon.	Water	13-18	catechol oxidase B, chloroplastic	Solanum tuberosum	119-137
30531104-4	2018	Our results confirmed that the adsorption of myoglobin into the silica mesopores induced significant changes in the positions and areas of freezing/melting peaks of the pore water.	Water	174-179	myoglobin	Homo sapiens	45-54
17179469-1	2007	Degarelix (FE 200486) is a member of a new class of water-soluble (&gt;50 mg/ml) gonadotropin-releasing hormone (GnRH) antagonists in clinical development for prostate cancer.	Water	52-57	gonadotropin releasing hormone 1	Rattus norvegicus	81-111
17179469-1	2007	Degarelix (FE 200486) is a member of a new class of water-soluble (&gt;50 mg/ml) gonadotropin-releasing hormone (GnRH) antagonists in clinical development for prostate cancer.	Water	52-57	gonadotropin releasing hormone 1	Rattus norvegicus	113-117
30531104-5	2018	The decrease in heat of fusion of the pore water after myoglobin adsorption could be utilized to quantify the amount of myoglobin inside the silica mesopores.	Water	43-48	myoglobin	Homo sapiens	55-64
30531104-5	2018	The decrease in heat of fusion of the pore water after myoglobin adsorption could be utilized to quantify the amount of myoglobin inside the silica mesopores.	Water	43-48	myoglobin	Homo sapiens	120-129
29434104-0	2018	Detection of Paracetamol in Water and Urea in Artificial Urine with Gold Nanoparticle@Al Foil Cost-efficient SERS Substrate.	Water	28-33	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	109-113
17454565-2	2007	In this study, 101 plant extracts (methanol or water extracts) were screened for their inhibitory activities against tyrosinase, (L-3, 4,-dihydroxyphenylalanine) L-DOPA oxidation, and melanin biosynthesis in B16 mouse melanoma cells.	Water	47-52	tyrosinase	Mus musculus	117-127
29103957-1	2018	Apical plasma membrane accumulation of the water channel Aquaporin-2 (AQP2) in kidney collecting duct principal cells is critical for body water homeostasis.	Water	43-48	aquaporin 2	Homo sapiens	57-68
29129744-11	2018	In conclusion, this study demonstrated that E. pekinensis induces inflammation and increases the expression of AQP3, causing disorders of water metabolism, which may lead to gastrointestinal side effects such as diarrhea.	Water	138-143	aquaporin 3 (Gill blood group)	Homo sapiens	111-115
17356517-16	2007	The differential expression of Kir4.1 and AQP4 during EIU implies a disturbance of water and potassium transport in the retina, which may contribute to the retinal edema during ocular inflammation.	Water	83-88	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	31-37
17356517-16	2007	The differential expression of Kir4.1 and AQP4 during EIU implies a disturbance of water and potassium transport in the retina, which may contribute to the retinal edema during ocular inflammation.	Water	83-88	aquaporin 4	Rattus norvegicus	42-46
29692268-3	2018	OBJECTIVE: New insights into water metabolism in the brain have opened the way for molecular targeted treatment, with aquaporin 4 channels (AQP4) taking center stage.	Water	29-34	aquaporin 4	Rattus norvegicus	118-138
17043812-9	2007	The results suggest that hyperosmotic stress is an important activator of AQP-5 in human airway epithelium, leading to significantly increased transepithelial water permeability.	Water	159-164	aquaporin 5	Homo sapiens	74-79
29692268-3	2018	OBJECTIVE: New insights into water metabolism in the brain have opened the way for molecular targeted treatment, with aquaporin 4 channels (AQP4) taking center stage.	Water	29-34	aquaporin 4	Rattus norvegicus	140-144
17598476-1	2007	Principal mechanism of the transepithelial water permeability increase in the kidney collecting ducts in response to vasopressin involves insertion of aquaporin 2 (AQP2) into the apical membrane.	Water	43-48	aquaporin 2	Rattus norvegicus	151-162
28631388-8	2018	Amongst all the media, only EMT could maintain the proliferative capacity of HPDLFs significantly higher than the negative control, that is water (P &lt; 0.05) after 24 h storage.	Water	140-145	IL2 inducible T cell kinase	Homo sapiens	28-31
17598476-1	2007	Principal mechanism of the transepithelial water permeability increase in the kidney collecting ducts in response to vasopressin involves insertion of aquaporin 2 (AQP2) into the apical membrane.	Water	43-48	aquaporin 2	Rattus norvegicus	164-168
17291108-5	2007	The changes in water position appear to disrupt the D-O-O-D dihedral associated with the CST framework in space group P42/mbc which ultimately leads to the structural transition.	Water	15-20	cyclin dependent kinase 20	Homo sapiens	118-121
28780418-1	2018	Photocrosslinkable water-soluble maleilated chitosan and methacrylated poly (vinyl alcohol) were synthesized and therefore maleilated chitosan/methacrylated poly (vinyl alcohol) (MCS/MPVA) hydrogels were prepared under UV radiation.	Water	19-24	sperm mitochondria-associated cysteine-rich protein	Mus musculus	179-182
17142287-1	2007	We report on the structure and dynamics of the Fe ligand cluster of reduced horse heart cytochrome c in solution, in a dried polyvinyl alcohol (PVA) film, and in two trehalose matrices characterized by different contents of residual water.	Water	233-238	cytochrome c, somatic	Equus caballus	88-100
29138806-3	2018	In the present study, we investigated the therapeutic effects of a novel and water soluble bis(hydroxymethyl) alkanoate curcuminoid derivative, MTH-3, on human breast adenocarcinoma MDA-MB-231 cells.	Water	77-82	nudix hydrolase 18	Homo sapiens	144-149
17286354-6	2007	The pair-distance distribution functions, p(r), extracted from the GIFT analysis of SAXS intensities show that the DSPE-PEGs form spherical-like micelles in water having the maximum diameter of approximately 16, 22, and 31 nm, respectively, for M(PEG) = 2000, 5000, and 12,000 Da and nearly identical aggregation numbers of 72 (+/-10%).	Water	157-162	progestagen associated endometrial protein	Homo sapiens	120-123
29136519-9	2018	The average uranium concentration of water samples from Syr Darya for the period from 2009 to 2014 was determined to be 20.1 (+-5.2) mug/L.	Water	37-42	YES1 pseudogene 1	Homo sapiens	56-59
16885154-3	2007	Along the collecting duct, the induction and subapical to plasma membrane translocation of the aquaporin-2 water channel in WD EP(1)(-/-) mice appeared equivalent to that of WD WT mice as determined by quantitative RT-PCR and immunohistochemistry.	Water	107-112	aquaporin 2	Mus musculus	95-106
16985212-1	2007	We recently identified a novel phosphorylation site, serine-261 (pS261), in the COOH-terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2).	Water	123-128	aquaporin 2	Rattus norvegicus	138-149
16985212-1	2007	We recently identified a novel phosphorylation site, serine-261 (pS261), in the COOH-terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2).	Water	123-128	aquaporin 2	Rattus norvegicus	151-155
28927888-7	2018	These deposits increased transepidermal water loss and caused irritation, particularly in AD patients carrying FLG mutations.	Water	40-45	filaggrin	Homo sapiens	111-114
17098798-4	2007	Here we study VASP-mediated actin-related proteins 2/3 (Arp2/3) complex-dependent actin dynamics using a substrate that mimics the fluid properties of the cell membrane: an oil-water interface.	Water	177-182	Actin-related protein 2	Drosophila melanogaster	56-62
28986113-0	2018	Water quality near Estonian harbours in the Baltic Sea as observed from entire MERIS full resolution archive.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	51-54
16982163-4	2007	The edited database was fit to five equations where the independent variables were solubility in octanol (S(OCT)) in water (S(AQ)) or molecular weight (MW), and combinations of those three variables; and the dependent variable was J(MAQ).	Water	117-122	plexin A2	Homo sapiens	108-111
29178346-2	2018	The East China Sea (ECS) is a complex and dynamic habitat with different water masses blending microbial communities.	Water	73-78	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	15-18
17270560-4	2007	Aquaporin 5 has been reported to be an important marker expressed in type I alveolar epithelial cells in late gestation and mediates water transport across the human airway epithelium.	Water	133-138	aquaporin 5	Homo sapiens	0-11
17927773-8	2007	Water transport capacity as well as the density of orthogonal arrays of intramembranous particles was increased in astrocytes cultured with the neuronal agrin isoform A4B8, but not with the endothelial and meningeal isoform A0B0.	Water	0-5	agrin	Mus musculus	153-158
28857333-13	2018	Small bowel water content increased from 39+-2 mL-1 to 51+-2 mL-1 postprandial.	Water	12-17	L1 cell adhesion molecule	Mus musculus	47-51
17643460-5	2007	In our model, HKII was up-regulated in the renal glomeruli of mice exposed to low levels of arsenic (10 ppb or 50 ppb) via their drinking water for up to 21 days.	Water	138-143	hexokinase 2	Mus musculus	14-18
17396588-6	2007	The ln alpha - 1/T plots for racemic chiral pesticides were linear at the range of 0-40 except for that of pyriproxyfen enantiomers in methanol/water and the chiral separations were controlled by enthalpy.	Water	144-149	adrenoceptor alpha 1D	Homo sapiens	7-16
28857333-13	2018	Small bowel water content increased from 39+-2 mL-1 to 51+-2 mL-1 postprandial.	Water	12-17	L1 cell adhesion molecule	Mus musculus	61-65
29253878-6	2017	We found that EHT administration protected animals from Abeta-induced cognitive impairments in both a radial-arm water maze and contextual fear conditioning task.	Water	113-118	amyloid beta (A4) precursor protein	Mus musculus	56-61
17436369-2	2007	To find out whether the immunohistochemical expression of neuropeptid Y (NPY) and leptin receptor (LR) in the rat hypothalamus is influenced by adlay seed water extract (adlay), obesity in rats was induced by high fat diet (HFD) for 8 weeks; these rats were injected with 50 mg/100 g body weight adlay daily for 4 weeks.	Water	155-160	leptin receptor	Rattus norvegicus	99-101
16982090-6	2007	These parameters were chosen to simultaneously investigate cell-to-cell distance on paracrine signaling and water content on IGF-1 diffusion by chondrocytes.	Water	108-113	insulin like growth factor 1	Bos taurus	125-130
17706735-5	2007	Here we show that the hsp70/eGFP transgene is strongly and specifically upregulated within the olfactory sensory neurons (OSNs) of transgenic zebrafish larvae following a brief 3-h exposure to water-borne cadmium.	Water	193-198	heat shock protein 8-like	Danio rerio	22-27
17368876-7	2007	Finally, the gel electrophoresis analysis demonstrated that SLN-SA re-suspended in PBS are unable to complex the DNA, while the SLN-SA re-dispersed in water displayed the same ability to bind DNA as the fresh prepared sample.	Water	151-156	sarcolipin	Homo sapiens	128-131
29067388-3	2017	The mice fed with 3% l-carnitine water for 12 weeks experienced a disturbance of the hepatic lipid metabolism, oxidative stress and inflammation, which was evidenced by abnormal TC, LDL, RAHFR and MDA levels, unusual AST, ALT, ALP, SOD and GSP-Px activities, and increased IF-1, IF-6 and TNF-alpha expressions.	Water	33-38	glutamic pyruvic transaminase, soluble	Mus musculus	222-225
18161335-3	2007	Therefore, the methods of gas chromatography and high performance liquid chromatography for analyzing the inks of ball-point pen and water-based pen cannot be used here.	Water	133-138	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	145-148
17430186-2	2007	These molecules belong to a family of vasopressin receptor antagonists, V2 in particular, that regulate optional renal water re-absorption via the synthesis and expression of aquaporin-2.	Water	119-124	aquaporin 2	Homo sapiens	175-186
29212002-2	2017	Here we propose an additional mechanism where active pumping of ions and water at the cell poles and the division furrow can also achieve the same type of shape change during cytokinesis without myosin contraction.	Water	73-78	myosin heavy chain 14	Homo sapiens	195-201
17227418-1	2007	The Black Sea, with its highly sulfidic water column, is the largest anoxic basin in the world.	Water	40-45	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	10-13
17283953-7	2007	Methylene blue adsorption confirmed that the GAC, even after almost four years of operation receiving surface water, had capacity to remove geosmin and MIB by adsorption.	Water	110-115	glutaminase	Homo sapiens	45-48
17676769-1	2007	Prolonged heating of holo bovine alpha-lactalbumin (BLA) at 80 degrees C in pH 7 phosphate buffer in the absence of a thiol initiator improves the surface activity of the protein at the air:water interface, as determined by surface tension measurements.	Water	190-195	lactalbumin alpha	Bos taurus	33-50
17676879-4	2007	Aggregation of a poly(phenylene ethynylene)-type CPE (PPE-CO2-) is induced by the addition of either water or Ca2+ to methanol solution, as indicated by absorption, fluorescence, dynamic light scattering, and fluorescence microscope measurements.	Water	101-106	carboxypeptidase E	Homo sapiens	49-52
17676879-5	2007	For quencher ions with a small molecular size, such as methyl viologen (MV2+), either the loose (induced by the addition of Ca2+) or the compact (induced by the addition of water) CPE chain aggregates are beneficial to the fluorescence quenching.	Water	173-178	carboxypeptidase E	Homo sapiens	180-183
28932831-3	2017	We demonstrate strong interaction effects in the SERS peaks, which we demonstrate are likely from the hydrogen bonding of water complexes in the vicinity of the CB[n]s.	Water	122-127	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	49-53
17655223-2	2007	K(UO2)(SO4)(OH)(H2O) (KUS1) crystallizes in space group P21/c, a = 8.0521(4) A, b = 7.9354(4) A, c = 11.3177(6) A, beta = 107.6780(10) degrees , V = 689.01(6) A3, and Z = 4.	Water	16-19	H3 histone pseudogene 16	Homo sapiens	56-61
17534672-5	2007	Water proton relaxation enhancements of 135 and 171% were observed upon binding of Gd2 and Gd3 to HSA, respectively, at 298 K and pH 7.4.	Water	0-5	GRDX	Homo sapiens	91-94
17708419-1	2007	The neurogenic protein Drosophila big brain (BIB), which is involved in the process of neuroblast determination, and the water channel aquaporin-1 (AQP1) are among a subset of the major intrinsic protein (MIP) channels that have been found to show gated monovalent cation channel activity.	Water	121-126	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	148-152
17708419-6	2007	The analogous mutation in AQP1 (E17N) did not impair ion channel activation by cGMP, but did knock out water channel function, although not via a dominant-negative effect.	Water	103-108	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	26-30
17708419-9	2007	The neurogenic protein Drosophila big brain (BIB), which is involved in the process of neuroblast determination, and the water channel aquaporin-1 (AQP1) are among a subset of the major intrinsic protein (MIP) channels that have been found to show gated monovalent cation channel activity.	Water	121-126	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	148-152
17708419-14	2007	The analogous mutation in AQP1 (E17N) did not impair ion channel activation by cGMP, but did knock out water channel function, although not via a dominant-negative effect.	Water	103-108	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	26-30
29208973-0	2017	Coupling of sea level and tidal range changes, with implications for future water levels.	Water	76-81	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	12-15
17722547-7	2007	The targeted conjugate demonstrated higher in vivo binding affinity to the DU145 xenografts than the SLK xenografts, resulting in a significant decrease of T1 values of water protons in the periphery of the DU145 tumors as shown in the MR T1 maps.	Water	169-174	STE20 like kinase	Homo sapiens	101-104
29208973-4	2017	Focusing on a subset of three stations with long records, probability density function (PDF) analyses of the 95% percentile exceedance of total sea level (TSL) show long-term changes of this high-water metric.	Water	196-201	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	144-147
17162572-3	2007	If the adsorption of chemicals on soils is partitioning in soil organic matter surrounding the soil mineral particles, the absorption constant (Kd) of a chemical in soil-water system could be stated as the distribution coefficient (or partition constant, Koc) of the chemical in the two adjunct immiscible phases--water and soil organic matter.	Water	170-175	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	255-258
29203835-6	2017	We furthermore performed functional characterization and found that AQP 2, 6 and 8 allowed flux of water whereas AQP3, 7, 9, 10, 11 and 12 also facilitated a glycerol flux.	Water	99-104	aquaporin 2	Homo sapiens	68-73
17162572-4	2007	The distribution coefficient (Koc) of chemicals calculated from the integral distribution equilibrium equation agrees well with the experimental adsorption coefficient (Kd, or experimental Koc) of chemicals determined in this study, for all the three different types of soils in water according to multiple-regression analysis.	Water	279-284	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	30-33
28967097-2	2017	Rapatar is a novel nanoformulated micellar of rapamycin, a putative inhibitor of mTOR that has been rationally designed to increase water solubility of rapamycin to facilitate p.o.	Water	132-137	mechanistic target of rapamycin kinase	Mus musculus	81-85
17168585-3	2006	The cross-coupling reaction can generally be effected using 2 mol % of PdCl2 and 6 mol % of PPh3 as a catalyst system in THF/H2O with Cs2CO3 as a base.	Water	125-128	protein phosphatase 4 catalytic subunit	Homo sapiens	92-96
29031064-4	2017	In this paper, we report a fragment-based screening campaign that combines Water-LOGSY NMR experiments and microscale thermophoresis approach to identify fragments that may be helpful for the development of novel IDO1 inhibitors as therapeutic agents in immune-oncology disorders.	Water	75-80	indoleamine 2,3-dioxygenase 1	Homo sapiens	213-217
17182778-7	2006	These changes in Abeta are correlated with improved spatial memory in the radial arm water maze.	Water	85-90	amyloid beta (A4) precursor protein	Mus musculus	17-22
16997875-5	2006	Like other amyloidogenic peptides, the natively folded HypF-N forms stable films at the air/water interface and inserts into synthetic phospholipid bilayers with efficiencies depending on the type of phospholipid.	Water	92-97	proteasome 26S subunit, non-ATPase 8	Homo sapiens	55-61
17149903-4	2006	The species composition and the water content of the primary complexes are precisely obtained by the systematic use of the contrast matching of (deuterated) polymer or protein in SANS, yielding the compactness and the inner charge ratio [-]/[+](inner).	Water	32-37	USH1 protein network component sans	Homo sapiens	179-183
17102865-7	2006	The Cd2+ ion fits exactly inside the macrocyclic cavity exhibiting coordination number eight by coordination to all the donor atoms of the ligand, and additionally to two oxygen atoms from one nitrate anion and one oxygen atom from a water molecule.	Water	234-239	CD2 molecule	Homo sapiens	4-7
17211564-2	2006	Glutathione-S-transferase (GST) catalyses the conjugation of glutathione with a variety of organic peroxides to form more water-soluble compounds.	Water	122-127	hematopoietic prostaglandin D synthase	Rattus norvegicus	0-25
17211564-2	2006	Glutathione-S-transferase (GST) catalyses the conjugation of glutathione with a variety of organic peroxides to form more water-soluble compounds.	Water	122-127	hematopoietic prostaglandin D synthase	Rattus norvegicus	27-30
16782845-4	2006	We have found that the DOX-mediated oxidant-induced toxicity in cardiac cells could be minimized by hyperthermia-induced small heat shock protein 27 (HSP27); that is, this protein acts as an endogenous antioxidant against DOX-derived oxidants such as H(2)O(2).	Water	251-256	heat shock protein family B (small) member 1	Homo sapiens	127-148
16782845-4	2006	We have found that the DOX-mediated oxidant-induced toxicity in cardiac cells could be minimized by hyperthermia-induced small heat shock protein 27 (HSP27); that is, this protein acts as an endogenous antioxidant against DOX-derived oxidants such as H(2)O(2).	Water	251-256	heat shock protein family B (small) member 1	Homo sapiens	150-155
17334057-6	2006	The marine basins, especially the outer basins, are dominated by large horizontal water fluxes that transport carbon and any associated contaminants into the Baltic Sea.	Water	82-87	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	165-168
17122239-3	2006	METHODS: The effects of the anti-neural-cell-adhesion molecule (anti-NCAM) were assessed on cold water swim stress-induced antinociception in Wistar rats with Freund"s adjuvant-induced inflammation of one hindpaw.	Water	97-102	neural cell adhesion molecule 1	Rattus norvegicus	69-73
17122239-9	2006	Moreover, anti-NCAM blocked cold-water-swim-induced analgesia in inflamed paws both to thermal and mechanical stimuli.	Water	33-38	neural cell adhesion molecule 1	Rattus norvegicus	15-19
17031388-4	2006	Histological and immunohistochemical techniques were used to estimate muscle integrity and the presence of aquaporin-4, a protein controlling water homeostasis.	Water	142-147	aquaporin 4	Rattus norvegicus	107-118
16977604-9	2006	AQ4, a water transporting protein, is upregulated in astrocytes in hypoxia suggesting the cells are involved in edema formation.	Water	7-12	aquaporin 4	Rattus norvegicus	0-3
22063224-2	2006	Principal component analysis (PCA) on the distributed (1)H NMR T(2) relaxation data revealed that the major changes in water characteristics during heating occur between 40 and 50 C. This is probably initiated by denaturation of myosin heads, which however, could not be detected in the DSC thermograms obtained directly on the meat.	Water	119-124	myosin heavy chain 14	Homo sapiens	229-235
22063224-4	2006	Simultaneous modelling of DSC and NMR data by partial least squares regression (PLSR) revealed a correlation between denaturation of myosin rods and light chains at ~53-58 C and heat-induced changes in myofibrillar water (T(2) relaxation time ~10-60ms) as well as between actin denaturation at ~80-82 C and expulsion of water from the meat.	Water	215-220	myosin heavy chain 14	Homo sapiens	133-139
17074445-4	2006	Such spatial distribution of AQP4 suggests a critical role that astrocytes expressing AQP4 play in the transport of water from blood/CSF to spinal cord parenchyma and vice versa.	Water	116-121	aquaporin 4	Rattus norvegicus	29-33
17074445-4	2006	Such spatial distribution of AQP4 suggests a critical role that astrocytes expressing AQP4 play in the transport of water from blood/CSF to spinal cord parenchyma and vice versa.	Water	116-121	aquaporin 4	Rattus norvegicus	86-90
17074445-10	2006	Finally, we also showed that SCI-induced changes in AQP4 protein levels correlate, both temporally and spatially, with persistent increases in water content in acutely and chronically injured spinal cords.	Water	143-148	aquaporin 4	Rattus norvegicus	52-56
17074445-11	2006	Although correlative, this finding suggests a possible link between AQP4 and impaired water transport/edema/syringomyelia in contused spinal cords.	Water	86-91	aquaporin 4	Rattus norvegicus	68-72
17117851-1	2006	A new nanoparticulate inorganic-organic hybrid-type positive contrast agent (CA), PGP/dextran-K01, was synthesized based on a GdPO4 inorganic core as a relaxation-time-shortening moiety and a dextran-coating, which generates monodispersibility in water, a high relaxation-time-shortening effect by retaining a large number of water molecules in proximity of the core and toxicity reduction in in-vivo studies.	Water	247-252	phosphoglycolate phosphatase	Homo sapiens	82-85
17117851-1	2006	A new nanoparticulate inorganic-organic hybrid-type positive contrast agent (CA), PGP/dextran-K01, was synthesized based on a GdPO4 inorganic core as a relaxation-time-shortening moiety and a dextran-coating, which generates monodispersibility in water, a high relaxation-time-shortening effect by retaining a large number of water molecules in proximity of the core and toxicity reduction in in-vivo studies.	Water	326-331	phosphoglycolate phosphatase	Homo sapiens	82-85
17101973-0	2006	Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel.	Water	81-86	aquaporin 2	Canis lupus familiaris	69-80
17101973-1	2006	To regulate mammalian water homeostasis, arginine-vasopressin (AVP) induces phosphorylation and thereby redistribution of renal aquaporin-2 (AQP2) water channels from vesicles to the apical membrane.	Water	22-27	aquaporin 2	Homo sapiens	128-139
17101973-1	2006	To regulate mammalian water homeostasis, arginine-vasopressin (AVP) induces phosphorylation and thereby redistribution of renal aquaporin-2 (AQP2) water channels from vesicles to the apical membrane.	Water	22-27	aquaporin 2	Homo sapiens	141-145
17101973-1	2006	To regulate mammalian water homeostasis, arginine-vasopressin (AVP) induces phosphorylation and thereby redistribution of renal aquaporin-2 (AQP2) water channels from vesicles to the apical membrane.	Water	147-152	aquaporin 2	Homo sapiens	128-139
17101973-1	2006	To regulate mammalian water homeostasis, arginine-vasopressin (AVP) induces phosphorylation and thereby redistribution of renal aquaporin-2 (AQP2) water channels from vesicles to the apical membrane.	Water	147-152	aquaporin 2	Homo sapiens	141-145
17101973-9	2006	Our data show that short-chain ubiquitination is involved in the regulated endocytosis, MVB sorting, and degradation of AQP2 and may be the mechanism used by AVP removal and PKC-activating hormones to reduce renal water reabsorption.	Water	214-219	aquaporin 2	Canis lupus familiaris	120-124
17154008-1	2006	A new model to estimate the soil-water partition coefficient of non-ionic organic compounds normalized to soil organic carbon, Koc, from the two-dimensional molecular structure is presented.	Water	33-38	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	127-130
17057149-3	2006	This article describes a simple pain-free alternative method of assessing digital nerve integrity by submerging the finger tip in water and observing if wrinkles develop on the skin.	Water	130-135	TOR signaling pathway regulator	Homo sapiens	123-126
17081961-7	2006	In these cases, mutations have been identified in the aquaporin-2 gene (AQP2), which is located in chromosome region 12q13 and codes for the vasopressin-sensitive water channel.	Water	163-168	aquaporin 2	Homo sapiens	54-65
17081961-7	2006	In these cases, mutations have been identified in the aquaporin-2 gene (AQP2), which is located in chromosome region 12q13 and codes for the vasopressin-sensitive water channel.	Water	163-168	aquaporin 2	Homo sapiens	72-76
17290740-0	2006	[Study on rat"s DNA damage of p53 induced by chlorinated acetic acids of drinking water disinfection by-products].	Water	82-87	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	30-33
17003427-1	2006	PURPOSE: To determine a role for the water- and glycerol-transporting protein aquaporin-3 (AQP3) in mammalian corneal epithelium, where it is expressed but has no known function.	Water	37-42	aquaporin 3 (Gill blood group)	Homo sapiens	78-89
17003427-1	2006	PURPOSE: To determine a role for the water- and glycerol-transporting protein aquaporin-3 (AQP3) in mammalian corneal epithelium, where it is expressed but has no known function.	Water	37-42	aquaporin 3 (Gill blood group)	Homo sapiens	91-95
17044001-2	2006	At present, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules (AQP0, AQP1, AQP2, AQP4, AQP5, AQP6, and AQP8), or also glycerol and other small solutes (AQP3, AQP7, AQP9, AQP10, AQP12).	Water	121-126	aquaporin 3 (Gill blood group)	Homo sapiens	227-231
17044001-2	2006	At present, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules (AQP0, AQP1, AQP2, AQP4, AQP5, AQP6, and AQP8), or also glycerol and other small solutes (AQP3, AQP7, AQP9, AQP10, AQP12).	Water	121-126	aquaporin 12A	Homo sapiens	252-257
17547926-1	2007	SANS is a powerful tool to characterise microemulsions, which can have a discontinuous droplet-like structure (oil in water (O/W), water in oil (W/O)) or a bicontinuous one.	Water	118-123	USH1 protein network component sans	Homo sapiens	0-4
17547926-1	2007	SANS is a powerful tool to characterise microemulsions, which can have a discontinuous droplet-like structure (oil in water (O/W), water in oil (W/O)) or a bicontinuous one.	Water	131-136	USH1 protein network component sans	Homo sapiens	0-4
17603937-7	2007	Interestingly, following treatment with H(2)O(2), nuclear thioredoxin-1 (Trx1) redox status was protected by NLS-Prx1, and cytoplasmic Trx1 was protected by NES-Prx1.	Water	40-45	thioredoxin	Homo sapiens	58-71
17603937-7	2007	Interestingly, following treatment with H(2)O(2), nuclear thioredoxin-1 (Trx1) redox status was protected by NLS-Prx1, and cytoplasmic Trx1 was protected by NES-Prx1.	Water	40-45	thioredoxin	Homo sapiens	73-77
17603937-7	2007	Interestingly, following treatment with H(2)O(2), nuclear thioredoxin-1 (Trx1) redox status was protected by NLS-Prx1, and cytoplasmic Trx1 was protected by NES-Prx1.	Water	40-45	peroxiredoxin 1	Homo sapiens	113-117
17603937-7	2007	Interestingly, following treatment with H(2)O(2), nuclear thioredoxin-1 (Trx1) redox status was protected by NLS-Prx1, and cytoplasmic Trx1 was protected by NES-Prx1.	Water	40-45	thioredoxin	Homo sapiens	135-139
17603937-7	2007	Interestingly, following treatment with H(2)O(2), nuclear thioredoxin-1 (Trx1) redox status was protected by NLS-Prx1, and cytoplasmic Trx1 was protected by NES-Prx1.	Water	40-45	peroxiredoxin 1	Homo sapiens	161-165
17592591-7	2007	In addition, to support the HSA protein binding studies of lipophilic [Gd(TTDA-N-MOBA)(H2O)]- and [Gd(TTDA-BBA)(H2O)] complexes, further protein-complex binding was studied by ultrafiltration and relaxivity studies.	Water	112-115	general transcription factor IIH subunit 5	Homo sapiens	102-106
17592591-8	2007	The binding constants (KA) of [Gd(TTDA-N-MOBA)(H2O)]- and [Gd(TTDA-BBA)(H2O)] are 8.6 x 10(2) and 1.0 x 10(4) dm3 mol(-1), respectively.	Water	47-50	general transcription factor IIH subunit 5	Homo sapiens	34-38
17592591-8	2007	The binding constants (KA) of [Gd(TTDA-N-MOBA)(H2O)]- and [Gd(TTDA-BBA)(H2O)] are 8.6 x 10(2) and 1.0 x 10(4) dm3 mol(-1), respectively.	Water	47-50	general transcription factor IIH subunit 5	Homo sapiens	62-66
17592591-8	2007	The binding constants (KA) of [Gd(TTDA-N-MOBA)(H2O)]- and [Gd(TTDA-BBA)(H2O)] are 8.6 x 10(2) and 1.0 x 10(4) dm3 mol(-1), respectively.	Water	72-75	general transcription factor IIH subunit 5	Homo sapiens	34-38
17592591-8	2007	The binding constants (KA) of [Gd(TTDA-N-MOBA)(H2O)]- and [Gd(TTDA-BBA)(H2O)] are 8.6 x 10(2) and 1.0 x 10(4) dm3 mol(-1), respectively.	Water	72-75	general transcription factor IIH subunit 5	Homo sapiens	62-66
17592591-10	2007	The KA value of [Gd(TTDA-BBA)(H2O)] is similar to that of MS-325 and indicates a stronger interaction of [Gd(TTDA-BBA)(H2O)] with HSA.	Water	30-33	general transcription factor IIH subunit 5	Homo sapiens	20-24
17592591-10	2007	The KA value of [Gd(TTDA-BBA)(H2O)] is similar to that of MS-325 and indicates a stronger interaction of [Gd(TTDA-BBA)(H2O)] with HSA.	Water	30-33	general transcription factor IIH subunit 5	Homo sapiens	109-113
17592591-10	2007	The KA value of [Gd(TTDA-BBA)(H2O)] is similar to that of MS-325 and indicates a stronger interaction of [Gd(TTDA-BBA)(H2O)] with HSA.	Water	119-122	general transcription factor IIH subunit 5	Homo sapiens	20-24
17592591-10	2007	The KA value of [Gd(TTDA-BBA)(H2O)] is similar to that of MS-325 and indicates a stronger interaction of [Gd(TTDA-BBA)(H2O)] with HSA.	Water	119-122	general transcription factor IIH subunit 5	Homo sapiens	109-113
17567043-7	2007	Our spectroscopic data revealed that this form contains a five-coordinate cob(II)alamin species, with a water molecule as an axial ligand to the cobalt.	Water	104-109	metabolism of cobalamin associated B	Homo sapiens	74-77
17567043-9	2007	This form was found to possess an effectively four-coordinate cob(II)alamin species that has neither water nor histidine coordinated to the cobalt center.	Water	101-106	metabolism of cobalamin associated B	Homo sapiens	62-65
17553469-3	2007	The present study examined the immunolocalization of aquaporin-1 (AQP1) and -4 (AQP4), a member of the water-selective channel, in the periodontal Ruffini endings of the rat incisors and trigeminal ganglion.	Water	103-108	aquaporin 4	Rattus norvegicus	80-84
16956186-0	2006	Stable helical beta 3-peptides in water via covalent bridging of side chains.	Water	34-39	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	15-21
16942056-4	2006	The interaction energy of a water molecule with the graphitic cluster was computed using ab initio methods at the MP2 level of theory and with the 6-31G(d = 0.25) basis set.	Water	28-33	tryptase pseudogene 1	Homo sapiens	114-117
28931557-7	2017	Recipients of C3G-treated NPI with or without C3G-supplemented drinking water achieved normoglycemia earlier compared to recipients of untreated islets.	Water	72-77	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	46-49
16954624-1	2006	Sodium trichloromethanesulfonate monohydrate, Na+.CCl3SO3-.H2O, crystallizes in P2(1)/a with all the atoms located in general positions.	Water	59-62	H3 histone pseudogene 16	Homo sapiens	80-85
17532793-0	2007	Identification of central nervous system sites involved in the water diuresis response elicited by central microinjection of nociceptin/ Orphanin FQ in conscious rats via c-Fos and inducible cAMP early repressor immunocytochemistry.	Water	63-68	prepronociceptin	Rattus norvegicus	125-135
17532793-0	2007	Identification of central nervous system sites involved in the water diuresis response elicited by central microinjection of nociceptin/ Orphanin FQ in conscious rats via c-Fos and inducible cAMP early repressor immunocytochemistry.	Water	63-68	prepronociceptin	Rattus norvegicus	137-148
28931557-8	2017	Mice that received C3G-treated islets with or without C3G-supplemented water displayed significantly lower blood glucose levels at 5-10 weeks post-transplantation compared to mice that received untreated islets.	Water	71-76	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	54-57
28931557-9	2017	Mice that received C3G-treated NPI and C3G-supplemented drinking water had significantly (P &lt; 0.05) lower blood glucose levels at 7 and 8 weeks post-transplantation compared to mice that received C3G-treated islets.	Water	65-70	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	19-22
17867431-10	2007	Meanwhile, in an intensive stress level in which the rats swam in 4 degrees C water, a high expression level of HSP70 mRNA was achieved in CDS groups, producing a dishabituation that proved the habitual expression from the other side.	Water	78-83	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	112-117
16928122-1	2006	An ab initio study of the stability, spectroscopic properties, and isomeric equilibrium of the hydrogen-bonded HCN...H2O and H2O...HCN isomers is presented.	Water	117-120	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	111-114
16928122-1	2006	An ab initio study of the stability, spectroscopic properties, and isomeric equilibrium of the hydrogen-bonded HCN...H2O and H2O...HCN isomers is presented.	Water	125-128	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	131-134
28931557-9	2017	Mice that received C3G-treated NPI and C3G-supplemented drinking water had significantly (P &lt; 0.05) lower blood glucose levels at 7 and 8 weeks post-transplantation compared to mice that received C3G-treated islets.	Water	65-70	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	39-42
16928122-3	2006	At the best theoretical level, CCSD(T), the H2O...HCN complex is more stable than the HCN...H2O complex by ca.	Water	44-47	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	50-53
28931557-9	2017	Mice that received C3G-treated NPI and C3G-supplemented drinking water had significantly (P &lt; 0.05) lower blood glucose levels at 7 and 8 weeks post-transplantation compared to mice that received C3G-treated islets.	Water	65-70	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	39-42
16928122-3	2006	At the best theoretical level, CCSD(T), the H2O...HCN complex is more stable than the HCN...H2O complex by ca.	Water	44-47	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	86-89
16928122-3	2006	At the best theoretical level, CCSD(T), the H2O...HCN complex is more stable than the HCN...H2O complex by ca.	Water	92-95	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	50-53
17553997-5	2007	In the present study, we found that water maze training significantly decreased CK2 activity in the rat hippocampal CA1 area but not in the dentate gyrus (DG) area.	Water	36-41	carbonic anhydrase 1	Rattus norvegicus	116-119
29263117-3	2017	We found that stabilized HIF-1alpha alters both transcellular and paracellular transport through renal epithelial monolayers in a manner consistent with secretory behavior, indicating localized ischemia-hypoxia may lead to altered salt and water transport through kidney epithelial monolayers.	Water	240-245	hypoxia inducible factor 1, alpha subunit	Mus musculus	25-35
17576906-10	2007	CONCLUSION: Aquaporins 1 and 2, associated with the plasma membrane region of ovine vocal fold epithelial cells, demonstrate the presence of an intrinsic mechanism to permit transcellular water flux in response to osmotic gradients.	Water	188-193	aquaporin-1	Ovis aries	0-30
16928122-3	2006	At the best theoretical level, CCSD(T), the H2O...HCN complex is more stable than the HCN...H2O complex by ca.	Water	92-95	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	86-89
16928122-8	2006	We find that under typical conditions of supersonic expansion experiments (T &lt; 150 K) H2O...HCN is essentially the only isomer present.	Water	89-92	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	95-98
16800017-2	2006	The pyrene moiety in PYCD is located above the narrower rim of the alpha-CD and is fully exposed to water.	Water	100-105	cathepsin K	Homo sapiens	21-25
16800017-3	2006	The acceptors are monocyclic organic molecules and, upon dissolution in water in the presence of PYCD, a fraction of the donor-acceptor systems is present as supramolecular dyads and the remaining fraction as free molecules.	Water	72-77	cathepsin K	Homo sapiens	97-101
28558434-5	2017	Solid-to-water partitioning for NG and 2,4-DNT was 100 times greater in propellant residues than in typical military ranges soils.	Water	9-14	5', 3'-nucleotidase, cytosolic	Homo sapiens	43-46
16815296-6	2006	However, HSP70-induction by zinc derivatives was not observed in MG. Mucosal lesion induced by water-immersion stress was significantly severe in MG compared with SD rats.	Water	95-100	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	9-14
24459495-5	2007	In conclusion, angiotensin II, and aldosterone could play a role in the regulation of renal water reabsorption by changing intracellular AQP2 targeting and/or AQP2 abundance, in addition to the vasopressin.	Water	92-97	aquaporin 2	Rattus norvegicus	137-141
24459496-5	2007	I/R injury or cisplatin induced marked down-regulation of AQP1, AQP2 and AQP3 water channels, and type-3 Na-H exchanger, Na,K-ATPase, and Na-K-2Cl cotransporters, in association with impairment of urinary concentration and tubular sodium reabsorption.	Water	78-83	aquaporin 3 (Gill blood group)	Rattus norvegicus	73-77
28570975-7	2017	Higher oxygen values indicated water mixing of the Sea of Marmara during winter 2012.	Water	31-36	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	51-54
17405146-7	2007	We also demonstrate that p34 (a component of the Arp2/3 complex), WASP/WAVE proteins, actin, alpha-tubulin, Rac, Cdc42, vinculin, and focal adhesion kinase are detected in water-shocked myelin purified from brain.	Water	172-177	actin related protein 2	Homo sapiens	49-53
17405146-7	2007	We also demonstrate that p34 (a component of the Arp2/3 complex), WASP/WAVE proteins, actin, alpha-tubulin, Rac, Cdc42, vinculin, and focal adhesion kinase are detected in water-shocked myelin purified from brain.	Water	172-177	WASP actin nucleation promoting factor	Homo sapiens	66-70
18970727-4	2006	Under the optimum conditions, preconcentration factors of 99 for E3, 73 for E2, 152 for E1 and 86 for P were obtained for 10mL water sample.	Water	127-132	small nucleolar RNA, H/ACA box 73A	Homo sapiens	88-97
28599362-0	2017	Determination of phytoplankton abundances (Chlorophyll-a) in the optically complex inland water - The Baltic Sea.	Water	90-95	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
16869597-1	2006	We present an analytical model that explains how, in humid environments, the electric field near a sharp tip enhances the formation of water menisci and bridges between the tip and a sample.	Water	135-140	TOR signaling pathway regulator	Homo sapiens	105-108
16869597-1	2006	We present an analytical model that explains how, in humid environments, the electric field near a sharp tip enhances the formation of water menisci and bridges between the tip and a sample.	Water	135-140	TOR signaling pathway regulator	Homo sapiens	173-176
16869649-2	2006	The water-insoluble catalysts [PdCl2(PhCN)2] and [PdCl2(PPh3)2] are also efficient, although they decompose more quickly to form black Pd0.	Water	4-9	protein phosphatase 4 catalytic subunit	Homo sapiens	56-60
17475815-1	2007	Germline inactivation of the mineralocorticoid receptor (MR) gene in mice results in postnatal lethality as a result of massive loss of sodium and water.	Water	147-152	nuclear receptor subfamily 3, group C, member 2	Mus musculus	29-55
17475815-1	2007	Germline inactivation of the mineralocorticoid receptor (MR) gene in mice results in postnatal lethality as a result of massive loss of sodium and water.	Water	147-152	nuclear receptor subfamily 3, group C, member 2	Mus musculus	57-59
17475819-4	2007	In comparison with wild-type littermates, Pkd1(+/-) mice showed inappropriate antidiuresis with higher urine osmolality and lower plasma osmolality at baseline, despite similar renal function and water intake.	Water	196-201	polycystin 1, transient receptor potential channel interacting	Mus musculus	42-46
17475819-5	2007	The Pkd1(+/-) mice had a decreased aquaretic response to both a water load and a selective V2R antagonist, despite similar V2R distribution and affinity.	Water	64-69	polycystin 1, transient receptor potential channel interacting	Mus musculus	4-8
28931469-8	2017	Our results indicated a respective 29% and 31% reduction in the total volume of CA1, and dentate gyrus in REM-SD+distilled water group as compared to the grid-floor control+distilled water group (p&lt;0.05).	Water	123-128	carbonic anhydrase 1	Rattus norvegicus	80-83
17524122-9	2007	More importantly, the discovery of the existence of the water-transporting protein aquaporin-3 in the viable epidermis and the presence of tight junction structures at the junction between the stratum granulosum and SC have brought new insights into the mechanisms of skin water distribution and barrier function.	Water	56-61	aquaporin 3 (Gill blood group)	Homo sapiens	83-94
17524122-9	2007	More importantly, the discovery of the existence of the water-transporting protein aquaporin-3 in the viable epidermis and the presence of tight junction structures at the junction between the stratum granulosum and SC have brought new insights into the mechanisms of skin water distribution and barrier function.	Water	273-278	aquaporin 3 (Gill blood group)	Homo sapiens	83-94
16574943-4	2006	The results have revealed that ROS levels, vascular endothelial growth factor (VEGF) expression, hypoxia-inducible factor-1alpha protein level, airway hyperresponsiveness, and vascular permeability are increased after inhalation of H(2)O(2).	Water	232-237	hypoxia inducible factor 1, alpha subunit	Mus musculus	97-128
28701330-5	2017	Noticeably, provision of drinking water with 0.3 mM PPi to mice heterozygous for inactivating mutations in Enpp1 during pregnancy robustly inhibited ectopic calcification in their Enpp1-/- offspring.	Water	34-39	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	107-112
16788862-5	2006	Furthermore, c-Myc expression repressed the activation of Akt induced by the toxic agents doxorubicin, cisplatin and H(2)O(2), and also by the physiological agonists PDGF and insulin.	Water	117-122	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	13-18
16624255-1	2006	Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane is critical to water reabsorption in renal collecting ducts and its regulation maintains body water homeostasis.	Water	15-20	aquaporin 2	Homo sapiens	42-46
16624255-1	2006	Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane is critical to water reabsorption in renal collecting ducts and its regulation maintains body water homeostasis.	Water	86-91	aquaporin 2	Homo sapiens	15-40
16624255-1	2006	Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane is critical to water reabsorption in renal collecting ducts and its regulation maintains body water homeostasis.	Water	86-91	aquaporin 2	Homo sapiens	42-46
16630534-4	2006	In polarised MDCK cells, the Aquaporin-2 water channel resides in intracellular vesicles and apical membrane, while the vasopressin-type 2 receptor, anion-exchanger 1 (AE1) protein and E-Cadherin mainly localise to the basolateral membrane.	Water	41-46	aquaporin 2	Canis lupus familiaris	29-40
16764820-0	2006	Water immersion is associated with an increase in aquaporin-2 excretion in healthy volunteers.	Water	0-5	aquaporin 2	Homo sapiens	50-61
16764820-1	2006	Here, we report the alterations in renal water handling in healthy volunteers during a 6 h thermoneutral water immersion at 34 to 36 degrees C. We found that water immersion is associated with a reversible increase in total urinary AQP2 excretion.	Water	41-46	aquaporin 2	Homo sapiens	232-236
16821116-4	2006	water extract (GWE) on the cognitive deficits and oxidative stress induced by the administration of Abeta(25-35) in mice.	Water	0-5	amyloid beta (A4) precursor protein	Mus musculus	100-105
16860289-1	2006	The aquaporin7 (AQP7) water channel is known to be a member of the aquaglyceroporins, which allow the rapid transport of glycerol and water.	Water	22-27	aquaporin 7	Mus musculus	4-14
16860289-1	2006	The aquaporin7 (AQP7) water channel is known to be a member of the aquaglyceroporins, which allow the rapid transport of glycerol and water.	Water	22-27	aquaporin 7	Mus musculus	16-20
16860289-1	2006	The aquaporin7 (AQP7) water channel is known to be a member of the aquaglyceroporins, which allow the rapid transport of glycerol and water.	Water	134-139	aquaporin 7	Mus musculus	4-14
16860289-1	2006	The aquaporin7 (AQP7) water channel is known to be a member of the aquaglyceroporins, which allow the rapid transport of glycerol and water.	Water	134-139	aquaporin 7	Mus musculus	16-20
16860289-5	2006	The water permeability of the proximal straight tubule brush border membrane measured by the stopped flow method was reduced in AQP7 knockout mice compared to wild-type mice (AQP7, 18.0+/-0.4 x 10(-3 )cm/s vs. wild-type, 20.0+/-0.3 x 10(-3) cm/s).	Water	4-9	aquaporin 7	Mus musculus	128-132
16872579-14	2006	In conclusion, we suggest that in addition to glycerol, AQP3 may be important for water transport and hydration in human skin epidermis.	Water	82-87	aquaporin 3 (Gill blood group)	Homo sapiens	56-60
16807403-7	2006	High water intake was associated with reduced renal expression of AVP V2 receptors (41.0%), B-Raf (15.4%), phosphorylated ERK (38.1%), and proliferating cell nuclear antigen-positive renal cells (61.7%).	Water	5-10	B-Raf proto-oncogene, serine/threonine kinase	Rattus norvegicus	92-97
16807403-9	2006	Taken together, these data demonstrate that water intake that is sufficient to cause persistent water diuresis suppresses B-Raf/MEK/ERK activity and decreases cyst and renal volumes in PCK rats.	Water	44-49	B-Raf proto-oncogene, serine/threonine kinase	Rattus norvegicus	122-127
16807403-9	2006	Taken together, these data demonstrate that water intake that is sufficient to cause persistent water diuresis suppresses B-Raf/MEK/ERK activity and decreases cyst and renal volumes in PCK rats.	Water	96-101	B-Raf proto-oncogene, serine/threonine kinase	Rattus norvegicus	122-127
16854066-0	2006	Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.	Water	121-126	heat shock protein 90 alpha family class A member 1	Homo sapiens	149-154
16707484-12	2006	Knockdown of NOX5 significantly decreased [(3)H]thymidine incorporation, which was restored by 10(-13) M H(2)O(2).	Water	105-110	NADPH oxidase 5	Homo sapiens	13-17
16836319-6	2006	Close to water saturation, the Cs3 and Ow6 sites are near each other (approximately 1.44 A) and are not occupied simultaneously.	Water	9-14	myozenin 3	Homo sapiens	31-34
16836448-7	2006	The MP2 reaction energies for water exchange gave gas-phase results that agreed with experiment in the range -5.5 to +3.3 kcal/mol.	Water	30-35	tryptase pseudogene 1	Homo sapiens	4-7
16545834-3	2006	It was observed that HNOA-1, being in lack of second aromatic ring, formed multilayer films at the air/water interface, while the other two compounds, with another aromatic ring and some hydrophilic groups, can be spread as monolayers on water surface.	Water	238-243	nitric oxide associated 1	Homo sapiens	21-27
16698796-7	2006	AQP9 has unique aqueous pore properties mediating the passage of a wide variety of non-charged solutes in addition to water.	Water	118-123	aquaporin 9	Mus musculus	0-4
17092842-0	2006	Water-soluble HPMA copolymer--prostaglandin E1 conjugates containing a cathepsin K sensitive spacer.	Water	0-5	cathepsin K	Homo sapiens	71-82
16787089-0	2006	Investigation of dipolar-mediated water-protein interactions in microcrystalline Crh by solid-state NMR spectroscopy.	Water	34-39	corticotropin releasing hormone	Homo sapiens	81-84
16787089-2	2006	In this article we report investigations on possible water-protein dipolar transfer mechanisms in the microcrystalline deuterated protein Crh by a set of solid-state NMR techniques.	Water	53-58	corticotropin releasing hormone	Homo sapiens	138-141
16483614-1	2006	The aim of the present study was to examine the expression of aquaporin-2 (AQP2), a member of the water channel family aquaporins (AQPs), in human uterine endometrium and its modulation of ovarian steroid hormone at the proliferative and secretory phases.	Water	98-103	aquaporin 2	Homo sapiens	62-73
16483614-1	2006	The aim of the present study was to examine the expression of aquaporin-2 (AQP2), a member of the water channel family aquaporins (AQPs), in human uterine endometrium and its modulation of ovarian steroid hormone at the proliferative and secretory phases.	Water	98-103	aquaporin 2	Homo sapiens	75-79
16821954-14	2006	Most importantly, the protein and the first water shell around ubiquitin and apo-calbindin are anticorrelated, whereas the first water shell around the SH2 domain is positively correlated.	Water	44-49	calbindin 1	Homo sapiens	81-90
16571723-3	2006	We have examined the mechanism of regulatory volume decrease (RVD) in salivary gland cells and report a novel association between osmosensing TRPV4 (transient receptor potential vanalloid 4) and AQP5 (aquaporin 5), which is required for regulating water permeability and cell volume.	Water	248-253	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	142-147
16571723-3	2006	We have examined the mechanism of regulatory volume decrease (RVD) in salivary gland cells and report a novel association between osmosensing TRPV4 (transient receptor potential vanalloid 4) and AQP5 (aquaporin 5), which is required for regulating water permeability and cell volume.	Water	248-253	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	149-189
17691206-2	2007	AQP3 expression is related to the expressions of other epidermal proteins involved in water maintenance (ie, CD44, claudin-1, and filaggrin).	Water	86-91	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
17325454-0	2007	Exogenous expression of rat aquaporin-3 enhances permeability to water and cryoprotectants of immature oocytes in the zebrafish (Danio rerio).	Water	65-70	aquaporin 3 (Gill blood group)	Rattus norvegicus	28-39
17325454-3	2007	In this study, we attempted to increase the permeability of immature zebrafish oocytes at stage III to water and cryoprotectants by exogenous expression of rat aquaporin-3.	Water	103-108	aquaporin 3 (Gill blood group)	Rattus norvegicus	160-171
17521429-1	2007	BACKGROUND: Endothelin-1 (ET-1) inhibition of vasopressin (AVP)-stimulated water reabsorption by the inner medullary collecting duct (IMCD) is associated with reduced cAMP accumulation.	Water	75-80	endothelin 1	Mus musculus	12-24
17521429-1	2007	BACKGROUND: Endothelin-1 (ET-1) inhibition of vasopressin (AVP)-stimulated water reabsorption by the inner medullary collecting duct (IMCD) is associated with reduced cAMP accumulation.	Water	75-80	endothelin 1	Mus musculus	26-30
17360705-6	2007	In addition, as compared with WT alpha-syn, S129D alpha-syn increased cytoplasmic and neuritic aggregates of itself in neuro2a cells treated with H(2)O(2) and serum deprivation.	Water	146-151	synuclein, alpha	Mus musculus	50-59
17492130-6	2007	Comparison between our crystal structures and the reported apo hDPPIV structures revealed that positively charged functional groups and conserved water molecules contributed to the interaction of ligands with hDPPIV.	Water	146-151	dipeptidyl peptidase 4	Homo sapiens	63-69
17492130-6	2007	Comparison between our crystal structures and the reported apo hDPPIV structures revealed that positively charged functional groups and conserved water molecules contributed to the interaction of ligands with hDPPIV.	Water	146-151	dipeptidyl peptidase 4	Homo sapiens	209-215
17166937-1	2007	The aquaporin (AQP)2 channel mediates the reabsorption of water in renal collecting ducts in response to arginine vasopressin (AVP) and hypertonicity.	Water	58-63	aquaporin 2	Homo sapiens	15-20
17229678-1	2007	In mammals, the hormonal regulation of water homeostasis is mediated by the aquaporin-2 water channel (Aqp2) of the collecting duct (CD).	Water	39-44	aquaporin 2	Mus musculus	76-87
17229678-1	2007	In mammals, the hormonal regulation of water homeostasis is mediated by the aquaporin-2 water channel (Aqp2) of the collecting duct (CD).	Water	39-44	aquaporin 2	Mus musculus	103-107
17229678-1	2007	In mammals, the hormonal regulation of water homeostasis is mediated by the aquaporin-2 water channel (Aqp2) of the collecting duct (CD).	Water	88-93	aquaporin 2	Mus musculus	76-87
17229678-1	2007	In mammals, the hormonal regulation of water homeostasis is mediated by the aquaporin-2 water channel (Aqp2) of the collecting duct (CD).	Water	88-93	aquaporin 2	Mus musculus	103-107
17229678-2	2007	Vasopressin induces redistribution of Aqp2 from intracellular vesicles to the apical membrane of CD principal cells, accompanied by increased water permeability.	Water	142-147	aquaporin 2	Mus musculus	38-42
17633179-5	2007	Significant positive correlations between partition coefficients (Koc), which was defined as the ratio of PAH isomers concentrations in surface sediment to those in seawater, and their octanol/water partition coefficients (Kow) were observed, i. e., the sorption constant Koc of PAHs in the bay may be predictd by the Kow for the compounds analyzed.	Water	168-173	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	66-69
17409310-5	2007	A severe urinary concentration defect in slc4a1-/- mice was accompanied by dysregulated expression and localization of the aquaporin-2 water channel.	Water	135-140	aquaporin 2	Mus musculus	123-134
17437246-5	2007	The structure of GIP(1-30)NH2 in DMSO-d6 and H2O has been studied using 2D NMR (total correlation spectroscopy (TOCSY), nuclear overhauser effect spectroscopy (NOESY), double quantum filtered-COSY (DQF-COSY), 13C-heteronuclear single quantum correlation (HSQC) experiments, and its conformation built by MD simulations with the NMR data as constraints.	Water	45-48	gastric inhibitory polypeptide	Bos taurus	17-20
17375926-0	2007	A water-mediated and substrate-assisted catalytic mechanism for Sulfolobus solfataricus DNA polymerase IV.	Water	2-7	alcohol dehydrogenase catalytic domain-containing protein	Saccharolobus solfataricus	88-105
17458180-4	2007	Mutations of the vasopressin-regulated water channel on the principal cells of the collecting duct, namely aquaporin (AQP)2, account for a minority of cases of congenital NDI.	Water	39-44	aquaporin 2	Homo sapiens	118-123
17450221-7	2007	Additionally, the water-soluble fractions of UFPs were sufficient to induce the expression of F3, F2RL2, and heme oxygenase 1 (HMOX1).	Water	18-23	coagulation factor II thrombin receptor like 2	Homo sapiens	98-103
17450221-7	2007	Additionally, the water-soluble fractions of UFPs were sufficient to induce the expression of F3, F2RL2, and heme oxygenase 1 (HMOX1).	Water	18-23	heme oxygenase 1	Homo sapiens	109-125
17450221-7	2007	Additionally, the water-soluble fractions of UFPs were sufficient to induce the expression of F3, F2RL2, and heme oxygenase 1 (HMOX1).	Water	18-23	heme oxygenase 1	Homo sapiens	127-132
17550212-1	2007	Activation of the V2 receptor by arginine vasopressin (AVP) results in trafficking of the water channel AQP2 to the luminal plasma membrane and a small amount into the urine.	Water	90-95	aquaporin 2	Homo sapiens	104-108
17339489-7	2007	The stimulatory role was confirmed by the observation that 12.5 microM H(2)O(2), a concentration found during inflammation, increased the expression of several proinflammatory NF-kappaB-dependent genes induced by TNF-alpha (e.g., IL-8, MCP-1, TLR2, and TNF-alpha).	Water	71-77	C-C motif chemokine ligand 2	Homo sapiens	236-241
17335485-1	2007	The effects of sea-level rise on the depth to the fresh water/salt water interface were simulated by using a density-dependent, three-dimensional numerical ground water flow model for a simplified hypothetical fresh water lens that is similar to shallow, coastal aquifers found along the Atlantic coast of the United States.	Water	56-61	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	15-18
17335485-1	2007	The effects of sea-level rise on the depth to the fresh water/salt water interface were simulated by using a density-dependent, three-dimensional numerical ground water flow model for a simplified hypothetical fresh water lens that is similar to shallow, coastal aquifers found along the Atlantic coast of the United States.	Water	67-72	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	15-18
17335485-1	2007	The effects of sea-level rise on the depth to the fresh water/salt water interface were simulated by using a density-dependent, three-dimensional numerical ground water flow model for a simplified hypothetical fresh water lens that is similar to shallow, coastal aquifers found along the Atlantic coast of the United States.	Water	67-72	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	15-18
17335485-2	2007	Simulations of sea-level rise of 2.65 mm/year from 1929 to 2050 resulted in an increase in water levels relative to a fixed datum, yet a net decrease in water levels relative to the increased sea-level position.	Water	91-96	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	15-18
17335485-2	2007	Simulations of sea-level rise of 2.65 mm/year from 1929 to 2050 resulted in an increase in water levels relative to a fixed datum, yet a net decrease in water levels relative to the increased sea-level position.	Water	153-158	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	15-18
17335485-4	2007	The difference in the change in water levels is attributed to the dampening effect of the stream on water level changes in response to sea-level rise.	Water	32-37	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	135-138
17335485-4	2007	The difference in the change in water levels is attributed to the dampening effect of the stream on water level changes in response to sea-level rise.	Water	100-105	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	135-138
17335485-8	2007	The difference in the change in the fresh water/salt water interface position is controlled by the difference in the net decline in water levels relative to local sea level.	Water	42-47	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	163-166
17335485-8	2007	The difference in the change in the fresh water/salt water interface position is controlled by the difference in the net decline in water levels relative to local sea level.	Water	53-58	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	163-166
17335485-8	2007	The difference in the change in the fresh water/salt water interface position is controlled by the difference in the net decline in water levels relative to local sea level.	Water	53-58	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	163-166
18072155-5	2007	METHOD: Cholinesterase activities in the plasma, erythrocytes, and whole blood of healthy male (n = 72) and female (n = 31) volunteers were measured by an electrometric method; the method involved the addition of 0.2 ml of blood sample to 3 ml of distilled water followed by 3 ml of barbital-phosphate buffer solution (pH 8.1).	Water	257-262	butyrylcholinesterase	Homo sapiens	8-22
17441354-8	2007	RESULTS: The water-soluble extract from PGL significantly inhibited, in the dose-dependent manner, the activities of alpha-glucosidase from small intestinal mucosa of diabetic mice.	Water	13-18	sucrase isomaltase (alpha-glucosidase)	Mus musculus	117-134
17441354-11	2007	CONCLUSION: The GPL water-soluble extract possesses the potential effect of inhibition on the alpha-glucosidase activity from the small intestinal mucosa of diabetic mouse.	Water	20-25	sucrase isomaltase (alpha-glucosidase)	Mus musculus	94-111
28701330-5	2017	Noticeably, provision of drinking water with 0.3 mM PPi to mice heterozygous for inactivating mutations in Enpp1 during pregnancy robustly inhibited ectopic calcification in their Enpp1-/- offspring.	Water	34-39	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	180-185
28602994-3	2017	Subcritical water-hydrolyzed fish collagen peptide (SWFCP) significantly inhibited lipid accumulation during the differentiation of 3T3-L1 preadipocytes, which was accompanied by decreased expression of CCAAT-enhancer-binding protein-alpha (C/EBP-alpha), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and adipocyte protein 2 (aP2) genes, key regulators of differentiation and maintenance of adipocytes.	Water	12-17	fatty acid binding protein 4, adipocyte	Mus musculus	343-346
31966420-5	2017	We demonstrated that Abeta peptide and H2O2 treatment could result in the translocation of RXRalpha and Nur77 from the nucleus to the mitochondria, and the ligand of RXR, 9-cis-RA, treatment can block the above phenomenon.	Water	39-43	nuclear receptor subfamily 4, group A, member 1	Mus musculus	104-109
17360670-4	2007	This approach employs melanoma differentiation-induced gene-7/interleukin-24 (mda-7/IL-24), a cancer-specific, apoptosis-inducing cytokine, in combination with nontoxic doses of a chemical compound from the endoperoxide class that decomposes in water generating singlet oxygen.	Water	245-250	interleukin 24	Homo sapiens	78-83
28800517-0	2017	Efficient inactivation of MS-2 virus in water by hydrodynamic cavitation.	Water	40-45	MS2	Homo sapiens	26-30
17188295-3	2007	Previously, the structure of a U2AF(65) variant in complex with poly(U) RNA suggested that rearrangement of flexible side-chains or bound water molecules may contribute to degenerate Py-tract recognition by U2AF(65).	Water	138-143	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	31-39
17188295-3	2007	Previously, the structure of a U2AF(65) variant in complex with poly(U) RNA suggested that rearrangement of flexible side-chains or bound water molecules may contribute to degenerate Py-tract recognition by U2AF(65).	Water	138-143	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	207-215
29038541-5	2017	At the recovery stage of EAU, serum concentrations of soluble CD83 (sCD83) were increased.	Water	25-28	CD83 molecule	Homo sapiens	62-66
17386575-1	2007	In this paper the validation of pKa determination in MDM-water mixtures is presented.	Water	57-62	secreted LY6/PLAUR domain containing 1	Homo sapiens	53-56
17386575-2	2007	The MDM-water mixture is a new multicomponent cosolvent mixture (consisting of equal volumes of methanol, dioxane and acetonitrile, as organic solvents) that dissolves a wide range of poorly water-soluble compounds.	Water	8-13	secreted LY6/PLAUR domain containing 1	Homo sapiens	4-7
17386575-2	2007	The MDM-water mixture is a new multicomponent cosolvent mixture (consisting of equal volumes of methanol, dioxane and acetonitrile, as organic solvents) that dissolves a wide range of poorly water-soluble compounds.	Water	191-196	secreted LY6/PLAUR domain containing 1	Homo sapiens	4-7
17386575-4	2007	Three different extrapolation procedures were compared in order to choose the best extrapolation in MDM-water mixture using a sub-set of 30 water-soluble compounds.	Water	104-109	secreted LY6/PLAUR domain containing 1	Homo sapiens	100-103
29038515-5	2017	In addition, Ag@C NCs after one-year storage in water still maintain high SERS-active capability.	Water	48-53	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	74-78
28735754-11	2017	CONCLUSIONS: Our study confirms the strict correlation that exists between left ventricular filling pressures and lung water content, estimated by dPAP and TI, respectively.	Water	119-124	hiiragi	Drosophila melanogaster	147-158
17309584-0	2007	5-Aminoisoquinolin-1(2H)-one, a water-soluble poly (ADP-ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats.	Water	32-37	poly (ADP-ribose) polymerase 1	Rattus norvegicus	46-74
17189326-6	2007	Thylakoids isolated from plants with a 5-fold FNR increase over the wild type displayed only moderate stimulation (approximately 20%) in the rates of electron transport from water to NADP+.	Water	174-179	ferredoxin--NADP reductase, root-type isozyme, chloroplastic	Nicotiana tabacum	46-49
28914534-4	2017	For a range of water clusters we demonstrate that this method exhibits a small prefactor and observed scalings of O(Ne2.4) for total energies and O(Ne3.1) for forces (Ne being the number of correlated electrons), outperforming MP2 for clusters with as few as 21 water molecules.	Water	15-20	tryptase pseudogene 1	Homo sapiens	227-230
28755583-3	2017	In the present review, three mechanisms are hypothesized for the interaction of hNoV with leafy green phyllospheres: 1) specific binding to histo-blood group antigen (HBGA)-like carbohydrates exposed on leaf surfaces and present on bacterial microbiota; 2) non-specific binding through electrostatic forces; and 3) internalization of hNoV through contaminated water (e.g. hydroponic feed water).	Water	360-365	cellular communication network factor 3	Homo sapiens	80-84
17156409-2	2007	Its binding to Gs-coupled vasopressin V2 receptors increases cyclic AMP (cAMP) and subsequently elicits the redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane (AQP2 shuttle), thereby facilitating water reabsorption from primary urine.	Water	130-135	aquaporin 2	Rattus norvegicus	144-155
17156409-2	2007	Its binding to Gs-coupled vasopressin V2 receptors increases cyclic AMP (cAMP) and subsequently elicits the redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane (AQP2 shuttle), thereby facilitating water reabsorption from primary urine.	Water	130-135	aquaporin 2	Rattus norvegicus	157-161
17156409-2	2007	Its binding to Gs-coupled vasopressin V2 receptors increases cyclic AMP (cAMP) and subsequently elicits the redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane (AQP2 shuttle), thereby facilitating water reabsorption from primary urine.	Water	130-135	aquaporin 2	Rattus norvegicus	217-221
17156409-2	2007	Its binding to Gs-coupled vasopressin V2 receptors increases cyclic AMP (cAMP) and subsequently elicits the redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane (AQP2 shuttle), thereby facilitating water reabsorption from primary urine.	Water	253-258	aquaporin 2	Rattus norvegicus	144-155
17156409-2	2007	Its binding to Gs-coupled vasopressin V2 receptors increases cyclic AMP (cAMP) and subsequently elicits the redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane (AQP2 shuttle), thereby facilitating water reabsorption from primary urine.	Water	253-258	aquaporin 2	Rattus norvegicus	157-161
28755583-3	2017	In the present review, three mechanisms are hypothesized for the interaction of hNoV with leafy green phyllospheres: 1) specific binding to histo-blood group antigen (HBGA)-like carbohydrates exposed on leaf surfaces and present on bacterial microbiota; 2) non-specific binding through electrostatic forces; and 3) internalization of hNoV through contaminated water (e.g. hydroponic feed water).	Water	388-393	cellular communication network factor 3	Homo sapiens	80-84
28861924-4	2017	The maximum concentration of Ni(OH)2 nanosheets in water without adding any additives reaches as high as 50 mg mL-1 , which can be printed on arbitrary substrates to form Ni(OH)2 thin films.	Water	51-56	L1 cell adhesion molecule	Mus musculus	111-115
28771976-6	2017	Inhibition of HDAC3 in the hippocampus attenuates spatial memory deficits, as indicated in the Morris water maze test, and decreases amyloid plaque load and Abeta levels in the brains of APP/PS1 mice.	Water	102-107	histone deacetylase 3	Mus musculus	14-19
17243837-7	2007	The reaction coordinates of the ribozyme reaction in TS, RC1-CD1 and RC4-CD2, are 2.35 and 2.33 A, respectively, compared to 2.37 and 2.36 A in water.	Water	144-149	chromobox 8	Homo sapiens	57-60
17243837-7	2007	The reaction coordinates of the ribozyme reaction in TS, RC1-CD1 and RC4-CD2, are 2.35 and 2.33 A, respectively, compared to 2.37 and 2.36 A in water.	Water	144-149	CD2 molecule	Homo sapiens	69-76
28831755-3	2017	A simple 72-h photodegradation study in purified water exhibited significant first-order kinetics with the kinetic constant k = 0.0303 h-1, and degradation halftime 22.8 h. The basic halftime could be reduced to 17.1 h by the addition of sea salt, and increase in temperature.	Water	49-54	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	238-241
17251414-2	2007	Here we present the novel findings that longitudinal water-maze spatial training produces a significant, albeit transient, improvement in subsequent learning performance and reduces amyloid beta (Abeta) and tau neuropathology.	Water	53-58	amyloid beta (A4) precursor protein	Mus musculus	196-201
28345222-1	2017	BACKGROUND: Corn zein is a predominatly hydrophobic protein, forming films with relatively good water resistance.	Water	96-101	zein	Zea mays	17-21
17214471-2	2007	The Morokuma decomposition scheme of ab initio interaction energies at the SCF level and the dispersion component at MP2 level were used to reproduce the molecular parameters of the solute-water interaction potential.	Water	189-194	tryptase pseudogene 1	Homo sapiens	117-120
16751983-12	2006	Susceptibility to EAU is related to the intrinsic capacity to mount higher inflammatory reactions and increased production of anti-IRBP IgG2a isotype is not necessarily a marker of this immunologic profile.	Water	18-21	immunoglobulin heavy variable V1-9	Mus musculus	136-141
28345222-2	2017	Tannic acid, especially in its oxidized form, is supposed to cross-link proteins including zein, which may be explored to further enhance the water resistance of zein films.	Water	142-147	zein	Zea mays	91-95
28345222-2	2017	Tannic acid, especially in its oxidized form, is supposed to cross-link proteins including zein, which may be explored to further enhance the water resistance of zein films.	Water	142-147	zein	Zea mays	162-166
17123747-10	2007	Sult2A1 converts bile acids, steroids and a number of drugs to the corresponding sulfated metabolites, which are readily eliminated from the body due to increased water solubility.	Water	163-168	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	Mus musculus	0-7
27726111-1	2017	Aquaporin-4 (AQP4), a water-channel protein, controls water fluxes into and out of the brain parenchyma.	Water	22-27	aquaporin 4	Rattus norvegicus	0-11
16672318-0	2006	Hyperosmolality in vivo upregulates aquaporin 2 water channel and Na-K-2Cl co-transporter in Brattleboro rats.	Water	48-53	aquaporin 2	Rattus norvegicus	36-47
27726111-1	2017	Aquaporin-4 (AQP4), a water-channel protein, controls water fluxes into and out of the brain parenchyma.	Water	22-27	aquaporin 4	Rattus norvegicus	13-17
21204498-0	2007	TRPV4 and TRPM3 as Volume-Regulated Cation Channels Changes of the extracellular osmolarity result in swelling or shrinkage of cells by increases or decreases in intracellular water along the ionic concentration gradient, thereby changing cell volume.	Water	176-181	transient receptor potential cation channel subfamily M member 3	Homo sapiens	10-15
28905057-0	2017	A water-mediated and substrate-assisted aminoacylation mechanism in the discriminating aminoacyl-tRNA synthetase GlnRS and non-discriminating GluRS.	Water	2-7	glutamyl-tRNA synthetase 2, mitochondrial	Homo sapiens	142-147
18002386-5	2007	In contrast, WE-3D-DWI sequence a RAGE-excitation pulse with a "binominal-pulse 1-1 or 1-2-1" was selected to water-excited (fat-saturated) diffusion imaging.	Water	110-115	MOK protein kinase	Rattus norvegicus	34-38
16481069-6	2006	The robust increase in vesicular glutamate transporter-2 mRNA and immunoreactivity after salt loading suggests that the cellular levels of vesicular glutamate transporter-2 in vasopressin neurons are regulated by alterations in water-electrolyte balance.	Water	228-233	solute carrier family 17 member 6	Rattus norvegicus	23-56
16481069-6	2006	The robust increase in vesicular glutamate transporter-2 mRNA and immunoreactivity after salt loading suggests that the cellular levels of vesicular glutamate transporter-2 in vasopressin neurons are regulated by alterations in water-electrolyte balance.	Water	228-233	solute carrier family 17 member 6	Rattus norvegicus	139-172
16707786-4	2006	APP transgenic mice receiving either anti-Abeta (2H6) or deglycosylated anti-Abeta (de-2H6) showed significant improvement in radial arm water maze performance compared with mice receiving a control antibody.	Water	137-142	amyloid beta (A4) precursor protein	Mus musculus	42-47
28905057-5	2017	Our investigations demonstrated the feasibility of a water-mediated, substrate-assisted catalysis pathway with rate limiting steps occurring at energy barriers of 25.0 and 25.4 kcal mol-1 for GlnRS and ND-GluRS, respectively.	Water	53-58	glutamyl-tRNA synthetase 2, mitochondrial	Homo sapiens	205-210
16707786-4	2006	APP transgenic mice receiving either anti-Abeta (2H6) or deglycosylated anti-Abeta (de-2H6) showed significant improvement in radial arm water maze performance compared with mice receiving a control antibody.	Water	137-142	amyloid beta (A4) precursor protein	Mus musculus	77-82
17487082-7	2007	In agreement with previous studies, thef-T curves for elastin were non-linear, leveling off above approximately 60 degrees C. Previous studies quote fe/f for elastin within the 50-70 degrees C range where volume changes (via loss of water) of elastin are thought to be negligible.	Water	233-238	elastin	Bos taurus	158-165
17487082-7	2007	In agreement with previous studies, thef-T curves for elastin were non-linear, leveling off above approximately 60 degrees C. Previous studies quote fe/f for elastin within the 50-70 degrees C range where volume changes (via loss of water) of elastin are thought to be negligible.	Water	233-238	elastin	Bos taurus	158-165
28934248-8	2017	Intriguingly, cell surface targeting of SLC4A11, a membrane transport protein (OH- /H+ /NH3 /H2O) of corneal endothelium, whose mutations have been identified in patients with corneal dystrophy, was impaired in Vps35-deficient cells and cornea.	Water	93-96	solute carrier family 4 member 11	Homo sapiens	40-47
17466962-8	2007	Oral administration of SMA-7 (60 mg/kg) to mice with 2% dextran sulfate sodium (DSS) in their drinking water, for 21 consecutive days, reduced significantly the severity of colonic injury.	Water	103-108	immunoglobulin mu binding protein 2	Mus musculus	23-26
16734761-3	2006	Emerging data suggest that TonEBP plays a key role in the urinary concentrating mechanism by stimulating the UT-A urea transporters and possibly AQP2 water channel.	Water	150-155	aquaporin 2	Mus musculus	145-149
16574604-2	2006	Treatment of rats with propranolol (Inderal 500 mg/L of water for 5 weeks) reduced by 48%, 50% and 29% the L-propranolol-, LHRH- or PDBu-induced testosterone secretion, respectively, when compared to cells from controls.	Water	56-61	gonadotropin releasing hormone 1	Rattus norvegicus	123-127
28718926-0	2017	ETS-NOCV Decomposition of the Reaction Force: The HCN/CNH Isomerization Reaction Assisted by Water.	Water	93-98	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	50-53
16430892-7	2006	These results suggest that fugu PRL regulates water and electrolyte balances through PRLR expressed in the osmoregulatory organs, as is the case with freshwater-adapted euryhaline species.	Water	46-51	prolactin	Takifugu rubripes	32-35
17092542-4	2007	Despite modest decreases in total PCB levels near the G30 sediment-water interface, historical increases in average degrees of chlorination may elevate the overall toxic risk at this site.	Water	67-72	DAOA antisense RNA 1	Homo sapiens	54-57
28718926-2	2017	This approach, together with the analysis of reaction electronic flux (REF), has been applied in a description of the changes in the electronic structure along the IRC pathway for the HCN/CNH isomerization reaction assisted by water.	Water	227-232	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	184-187
28615247-2	2017	Li-NDI is caused by lithium uptake by collecting duct principal cells and downregulation of aquaporin-2 (AQP2) water channels, which are essential for water uptake from tubular urine.	Water	111-116	aquaporin 2	Homo sapiens	92-103
17135396-1	2007	The cAMP/protein kinase A (PKA)-dependent insertion of water channel aquaporin-2 (AQP2)-bearing vesicles into the plasma membrane in renal collecting duct principal cells (AQP2 shuttle) constitutes the molecular basis of arginine vasopressin (AVP)-regulated water reabsorption.	Water	55-60	aquaporin 2	Homo sapiens	82-86
16618194-7	2006	As the rise in temperature causes a decrease in the water content of the NIPA gel particles, the gel particles becomes stickier on the cavity wall of polystyrene PPM.	Water	52-57	zinc finger C3HC-type containing 1	Homo sapiens	73-77
17135396-1	2007	The cAMP/protein kinase A (PKA)-dependent insertion of water channel aquaporin-2 (AQP2)-bearing vesicles into the plasma membrane in renal collecting duct principal cells (AQP2 shuttle) constitutes the molecular basis of arginine vasopressin (AVP)-regulated water reabsorption.	Water	55-60	aquaporin 2	Homo sapiens	172-176
16497331-4	2006	It loses a coordination bond with a water molecule bound in the open conformation of Gal-T1 while forming a new coordination bond with another water molecule in the closed conformation, creating an active ground-state structure that facilitates enzyme catalysis.	Water	36-41	beta-1,4-galactosyltransferase 1	Homo sapiens	85-91
28615247-2	2017	Li-NDI is caused by lithium uptake by collecting duct principal cells and downregulation of aquaporin-2 (AQP2) water channels, which are essential for water uptake from tubular urine.	Water	111-116	aquaporin 2	Homo sapiens	105-109
16497331-4	2006	It loses a coordination bond with a water molecule bound in the open conformation of Gal-T1 while forming a new coordination bond with another water molecule in the closed conformation, creating an active ground-state structure that facilitates enzyme catalysis.	Water	143-148	beta-1,4-galactosyltransferase 1	Homo sapiens	85-91
28615247-2	2017	Li-NDI is caused by lithium uptake by collecting duct principal cells and downregulation of aquaporin-2 (AQP2) water channels, which are essential for water uptake from tubular urine.	Water	151-156	aquaporin 2	Homo sapiens	92-103
28615247-2	2017	Li-NDI is caused by lithium uptake by collecting duct principal cells and downregulation of aquaporin-2 (AQP2) water channels, which are essential for water uptake from tubular urine.	Water	151-156	aquaporin 2	Homo sapiens	105-109
28190184-0	2017	Changes in Serum Adiponectin in Mice Chronically Exposed to Inorganic Arsenic in Drinking Water.	Water	90-95	adiponectin, C1Q and collagen domain containing	Mus musculus	17-28
16626254-1	2006	Water clusters (H(2)O)(n), n&lt;or=16, are produced by supersonic expansion of water vapor into vacuum, and then pick up a DCl molecule.	Water	0-5	protein interacting with PRKCA 1	Homo sapiens	113-117
18453106-4	2007	PLC activity is measured as the accumulation of inositol 1,4,5-trisphosphate (IP3), a water-soluble product, using a commercially available radioreceptor assay kit.	Water	86-91	heparan sulfate proteoglycan 2	Homo sapiens	0-3
28586729-10	2017	In virtue of the high-performance MTP1 and MTP2 FPNs, including high water dispersion, good particle stability, and excellent cytocompatibility, this work would inspire more researches about high-performance biocompatible fluorescent polymers for biomedical application.	Water	69-74	solute carrier family 40 member 1	Homo sapiens	34-38
17654319-1	2007	The aquaporin-2 (AQP2) plays a key role in AVP-induced absorption of water, and its urinary excretion is related to its function.	Water	69-74	aquaporin 2	Homo sapiens	4-15
17654319-1	2007	The aquaporin-2 (AQP2) plays a key role in AVP-induced absorption of water, and its urinary excretion is related to its function.	Water	69-74	aquaporin 2	Homo sapiens	17-21
17654319-2	2007	We aimed to test if the assumption of water with different mineral content can modify the expression of AQP2, leading to a change in AQP2 urinary concentration, in 20 healthy young subjects.	Water	38-43	aquaporin 2	Homo sapiens	104-108
17654319-2	2007	We aimed to test if the assumption of water with different mineral content can modify the expression of AQP2, leading to a change in AQP2 urinary concentration, in 20 healthy young subjects.	Water	38-43	aquaporin 2	Homo sapiens	133-137
17654319-7	2007	AQP2 urinary excretion was significantly reduced after water assumption with respect to the basal level and it was lower after LM than after HM water assumption.	Water	55-60	aquaporin 2	Homo sapiens	0-4
17654319-7	2007	AQP2 urinary excretion was significantly reduced after water assumption with respect to the basal level and it was lower after LM than after HM water assumption.	Water	144-149	aquaporin 2	Homo sapiens	0-4
16562952-10	2006	0.5H2O, and [Ag2(Og)(H2O)4].H2O are presented.	Water	21-24	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	13-16
28779427-7	2017	Concentrations of all the studied HM/Ms and nutrients in water entering the EDD were significantly higher than the effluent.	Water	57-62	ubiquitin protein ligase E3 component n-recognin 5	Homo sapiens	76-79
16171936-1	2006	Storm in-sag inlets, which typically have inflow capture efficiency of 100%, can violate the allowable water spread criterion of roadways, thus slowing the traffic movement and contributing to accidents.	Water	103-108	S-antigen visual arrestin	Homo sapiens	9-12
16171936-3	2006	In this study, the water spread on pavement for in-sag grates located in a residential area in Kuwait is analyzed in terms of return period and clogging factor.	Water	19-24	S-antigen visual arrestin	Homo sapiens	51-54
16798777-1	2006	The plasma membrane of skeletal muscles contains water channels such as aquaporin 4 (AQP4), aquaporin 3 (AQP3) and aquaporin 7 (AQP7).	Water	49-54	aquaporin 4	Rattus norvegicus	72-83
16798777-1	2006	The plasma membrane of skeletal muscles contains water channels such as aquaporin 4 (AQP4), aquaporin 3 (AQP3) and aquaporin 7 (AQP7).	Water	49-54	aquaporin 4	Rattus norvegicus	85-89
16798777-1	2006	The plasma membrane of skeletal muscles contains water channels such as aquaporin 4 (AQP4), aquaporin 3 (AQP3) and aquaporin 7 (AQP7).	Water	49-54	aquaporin 3 (Gill blood group)	Rattus norvegicus	92-103
17654319-9	2007	Considering that AQP2 can play a role in pathogenesis of hypertension, our demonstration that AVP-mediated AQP2 urinary excretion is strictly influenced by the consumption of water with different mineral content suggests a new, interesting field of investigation related to the link between blood pressure alterations and nutritional habits.	Water	175-180	aquaporin 2	Homo sapiens	17-21
17654319-9	2007	Considering that AQP2 can play a role in pathogenesis of hypertension, our demonstration that AVP-mediated AQP2 urinary excretion is strictly influenced by the consumption of water with different mineral content suggests a new, interesting field of investigation related to the link between blood pressure alterations and nutritional habits.	Water	175-180	aquaporin 2	Homo sapiens	107-111
17173447-6	2006	The pKa* of the coordinated water in [(eta6-p-cym)Ru(azpyz-NMe2)OH2]2+ (13A) is 4.60, consistent with the increased acidity of the ruthenium center upon coordination to the azo ligand.	Water	28-33	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	59-63
16837052-9	2006	The EPO-treated group had statistically more brain water content at 24h than the untreated group.	Water	51-56	erythropoietin	Rattus norvegicus	4-7
17129028-5	2006	The host-guest binding interactions between water-soluble dendrimers 1Cob+-3Cob+ and the cucurbit[7]uril (CB7) host were investigated using 1H NMR spectroscopy, MALDI-TOF mass spectrometry, and electrochemical techniques.	Water	44-49	metabolism of cobalamin associated B	Homo sapiens	70-73
16848764-1	2006	AQP3 (aquaporin-3), known as an integral membrane channel in epidermal keratinocytes, facilitates water and glycerol movement into and out of the skin.	Water	98-103	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
16848764-1	2006	AQP3 (aquaporin-3), known as an integral membrane channel in epidermal keratinocytes, facilitates water and glycerol movement into and out of the skin.	Water	98-103	aquaporin 3 (Gill blood group)	Homo sapiens	6-17
16848764-4	2006	CuSO4 and NiCl2, previously known as AQP3 water transport inhibitors, as well as two other bivalent heavy metals Mn2+ and Co2+, inhibited EGF-induced cell migration in human skin fibroblasts.	Water	42-47	aquaporin 3 (Gill blood group)	Homo sapiens	37-41
16848764-4	2006	CuSO4 and NiCl2, previously known as AQP3 water transport inhibitors, as well as two other bivalent heavy metals Mn2+ and Co2+, inhibited EGF-induced cell migration in human skin fibroblasts.	Water	42-47	epidermal growth factor	Canis lupus familiaris	138-141
17145855-5	2006	SMO/PAOh1 oxidizes spermine into spermidine, 3-aminopropanal, and H(2)O(2).	Water	66-71	smoothened, frizzled class receptor	Homo sapiens	0-3
16830357-7	2006	Through MS2 and MS3 studies of a synthetic peptide standard AGHKLL and its chemically labeled and isotope-encoded forms, we discovered that the water loss from the b(3) ion involves the carbonyl group of His, the hydrogen connected to the alpha-carbon of Gly, and the amide hydrogen of His.	Water	144-149	MS2	Homo sapiens	8-11
17078650-1	2006	The association of neuropeptide Y (NPY) with air-water interfaces and with phospholipid monolayers on water subphases and on physiological buffer has been investigated.	Water	49-54	neuropeptide Y	Homo sapiens	19-33
17078650-1	2006	The association of neuropeptide Y (NPY) with air-water interfaces and with phospholipid monolayers on water subphases and on physiological buffer has been investigated.	Water	49-54	neuropeptide Y	Homo sapiens	35-38
17078650-1	2006	The association of neuropeptide Y (NPY) with air-water interfaces and with phospholipid monolayers on water subphases and on physiological buffer has been investigated.	Water	102-107	neuropeptide Y	Homo sapiens	19-33
17078651-0	2006	Interaction of the neurotransmitter, neuropeptide Y, with phospholipid membranes: infrared spectroscopic characterization at the air/water interface.	Water	133-138	neuropeptide Y	Homo sapiens	37-51
17078651-1	2006	The association of neuropeptide Y (NPY) at the air/water interface and with phospholipid monolayers on water as subphase has been investigated using external infrared reflection absorption spectroscopy (IRRAS).	Water	103-108	neuropeptide Y	Homo sapiens	19-33
17078651-2	2006	Studies of the conformation and orientation of NPY suggest that it adopts an alpha-helical structure and is oriented parallel to the air/water interface in neat peptide monolayers.	Water	137-142	neuropeptide Y	Homo sapiens	47-50
30754158-3	2006	Arginine vasopressin stimulation of renal V2 vasopressin receptors in the basolateral membrane of principal cells induces aquaporin-2-mediated water reabsorption in the kidney.	Water	143-148	aquaporin 2	Homo sapiens	122-133
16563717-4	2006	Water-dispersible forms of various carotenoids (beta-carotene, lutein and lycopene) from natural sources in microemulsion were used to study effects of carotenoids on tissue factor activity in human endothelial cells.	Water	0-5	coagulation factor III, tissue factor	Homo sapiens	167-180
16794826-5	2006	Furthermore, all leaves of win3.12::kn1 shoots remained green and healthy 3 weeks after excision and incubation in water, while older leaves of control shoots senesced under the same conditions.	Water	115-120	homeobox protein knotted-1-like 1	Nicotiana tabacum	36-39
17269337-3	2006	The water-soluble P concentration in the culture media inoculated with OP1 , OP2 and NOP3 increased 38.53, 64.53 and 54.06 fold, respectively, compared with the control.	Water	4-9	bone morphogenetic protein 8b	Homo sapiens	77-80
17047754-2	2006	Rate coefficients at (297+/-1 K) are also reported for the relaxation of OH(v=2) by D2O and the relaxation of OD(v=2) by H2O and D2O.	Water	121-124	T cell receptor gamma variable 9	Homo sapiens	113-116
16927075-1	2006	OBJECTIVE: The aim of this study was to investigate the impact of the water-soluble poly-(ADP)-ribose-polymerase (PARP) inhibitor 5-aminoisoquinolinone (5-AIQ) on liver microcirculation and function after haemorrhagic shock and resuscitation.	Water	70-75	poly (ADP-ribose) polymerase 1	Rattus norvegicus	84-112
17075179-1	2006	To investigate the role of ZmPIP1-1 and ZmPIP1-2 in water uptake of roots and drought resistance of crops, semi-quantitative PCR was used to examine the expression of ZmPIP1-1 and ZmPIP1-2 in root systems of different maize genotypes under water deficit.	Water	52-57	aquaporin PIP1-1	Zea mays	27-35
16890240-6	2006	This is the first MMP-1 structure that is free of inhibitor and a water molecule essential for peptide hydrolysis is observed coordinated with the active site zinc.	Water	66-71	matrix metallopeptidase 1	Homo sapiens	18-23
16918518-14	2006	Increased expression and altered cellular distribution of AQP3 is found in eczema and this may contribute to water loss.	Water	109-114	aquaporin 3 (Gill blood group)	Homo sapiens	58-62
16946515-11	2006	Among them, water extract of Galla Chinensis and ethanol extract of Radix Clematidis exhibited higher depigmentation activity and caused lower tyrosinase activity in cell culture assays and are worthy to be further studied.	Water	12-17	tyrosinase	Mus musculus	143-153
16907758-6	2006	Measurements of Leucine aminopeptidase and alpha-glucosidase activities in fractionated lake water (0.2-1.2, 1.2-5 and &gt;5 microm fractions) indicated that proteolytic activity was always higher and that particle-associated bacteria have higher enzymatic activities than free-living bacteria.	Water	93-98	sucrase-isomaltase	Homo sapiens	43-60
17017983-10	2006	Tenoxicam and piroxicam known as COX-1 inhibitors demonstrated higher partition capacity in liposomes/water systems together with a smaller ability to change the membrane fluidity and surface potential.	Water	102-107	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	33-38
16928122-0	2006	Ab initio study of the isomeric equilibrium of the HCN...H2O and H2O...HCN hydrogen-bonded clusters.	Water	57-60	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	51-54
16928122-0	2006	Ab initio study of the isomeric equilibrium of the HCN...H2O and H2O...HCN hydrogen-bonded clusters.	Water	65-68	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	71-74
16895745-7	2006	A water-soluble LXR agonist caused naked oocytes, but not cumulus enclosed oocytes (CEO), from wild type mice to resume meiosis significantly more often than control oocytes.	Water	2-7	nuclear receptor subfamily 1, group H, member 2	Mus musculus	16-19
16865175-2	2006	Two models have been tested that start from the outer sphere complexes, (H2O)[U(A)O2F(OH2)4+]...[U(B)O2(OH2)5(2+)] and [U(A)O2F(OH2)4+]...[U(B)O2(OH2)5(2+)]; the geometry and energies of the intermediates and transition states along possible reaction pathways have been calculated using different ab initio methods, SCF, B3LYP and MP2.	Water	73-76	tryptase pseudogene 1	Homo sapiens	331-334
16884278-0	2006	Intermolecular interaction of myoglobin with water molecules along the pH denaturation curve.	Water	45-50	myoglobin	Homo sapiens	30-39
16773666-4	2006	Furthermore, Bi(OTf)(3)- and Ga(OTf)(3)-basic ligand complexes have also been found to be stable in water, and have been used as water-compatible Lewis acids.	Water	100-105	POU class 5 homeobox 1	Homo sapiens	13-38
16773666-4	2006	Furthermore, Bi(OTf)(3)- and Ga(OTf)(3)-basic ligand complexes have also been found to be stable in water, and have been used as water-compatible Lewis acids.	Water	129-134	POU class 5 homeobox 1	Homo sapiens	13-38
16773666-5	2006	This application is particularly significant, as Bi(OTf)(3) and Ga(OTf)(3) themselves are unstable in the presence of water, but are stabilized by the basic ligands.	Water	118-123	POU class 5 homeobox 1	Homo sapiens	49-58
16825342-2	2006	Binding of this hormone to the vasopressin V2 receptor (V2R) leads to insertion of aquaporin-2 (AQP2) water channels in the apical membrane, thereby allowing water reabsorption from the pro-urine to the interstitium.	Water	102-107	aquaporin 2	Homo sapiens	83-94
16825342-2	2006	Binding of this hormone to the vasopressin V2 receptor (V2R) leads to insertion of aquaporin-2 (AQP2) water channels in the apical membrane, thereby allowing water reabsorption from the pro-urine to the interstitium.	Water	102-107	aquaporin 2	Homo sapiens	96-100
16825342-2	2006	Binding of this hormone to the vasopressin V2 receptor (V2R) leads to insertion of aquaporin-2 (AQP2) water channels in the apical membrane, thereby allowing water reabsorption from the pro-urine to the interstitium.	Water	158-163	aquaporin 2	Homo sapiens	83-94
16825342-2	2006	Binding of this hormone to the vasopressin V2 receptor (V2R) leads to insertion of aquaporin-2 (AQP2) water channels in the apical membrane, thereby allowing water reabsorption from the pro-urine to the interstitium.	Water	158-163	aquaporin 2	Homo sapiens	96-100
16893299-5	2006	NPY significantly increased the number of meals initiated for water, 0.1% saccharin, and 1.0 M sucrose solutions, but meal size was only increased for 1.0 M sucrose.	Water	62-67	neuropeptide Y	Homo sapiens	0-3
16890610-5	2006	METHODS: Mtgr1-null mice were given 3% DSS in their drinking water for 4 days and the colons examined at various times thereafter for ulceration and for changes in proliferation and apoptosis.	Water	61-66	CBFA2/RUNX1 translocation partner 2	Mus musculus	9-14
16673398-3	2006	Overexpression of Galpha(s-L) to a level twice that of the vector-transfected cells did not directly affect cell viability but significantly increased the sensitivity to induction of cell death by serum deprivation and other apoptotic stimuli, including staurosporine, H(2)O(2), and tunicamycin.	Water	269-275	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	18-28
16877707-0	2006	Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration.	Water	22-27	reticulon 4	Homo sapiens	0-4
16877707-2	2006	Very surprisingly, we recently discovered that Nogo-60 was soluble and structured in salt-free water, thus allowing the determination of the first Nogo structure by heteronuclear NMR spectroscopy.	Water	95-100	reticulon 4	Homo sapiens	47-51
16877707-2	2006	Very surprisingly, we recently discovered that Nogo-60 was soluble and structured in salt-free water, thus allowing the determination of the first Nogo structure by heteronuclear NMR spectroscopy.	Water	95-100	reticulon 4	Homo sapiens	147-151
16905103-6	2006	In addition, a layer of ordered water molecules mediates key interactions between ubiquitin and USP2.	Water	32-37	ubiquitin specific peptidase 2	Homo sapiens	96-100
16818232-5	2006	Flexible side chains and bound water molecules form the majority of the base contacts and potentially could rearrange when the U2AF(65) structure adapts to different Py tract sequences.	Water	31-36	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	127-134
16790925-9	2006	The R67 DHFR active site is unique: it has D2 symmetry and is a large active site with a pentagonal network of water molecules and exposure of backbone atoms to solvent; the central pore is favorable for planar ring-stacking interactions.	Water	111-116	dihydrofolate reductase	Homo sapiens	8-12
16449354-1	2006	Vasopressin increases urine concentration by stimulating plasma membrane accumulation of aquaporin-2 (AQP2) in collecting duct principal cells, allowing bulk water flow across the collecting duct from lumen to interstitium down an osmotic gradient.	Water	158-163	aquaporin 2	Rattus norvegicus	89-100
16449354-1	2006	Vasopressin increases urine concentration by stimulating plasma membrane accumulation of aquaporin-2 (AQP2) in collecting duct principal cells, allowing bulk water flow across the collecting duct from lumen to interstitium down an osmotic gradient.	Water	158-163	aquaporin 2	Rattus norvegicus	102-106
16554128-5	2006	In this work, description is given of the in vitro ability of the matrix to deliver in a controlled manner a protein, Myoglobin, in distilled water, simulated gastric fluid and simulated intestinal fluid; the release, simulating a gastric passage, followed by an enteric delivery, was also carried out.	Water	142-147	myoglobin	Homo sapiens	118-127
16624821-1	2006	Recent reports suggest the expression of aquaporin (AQP)-type water channels in mitochondria from liver (AQP8) (Calamita, G., Ferri, D., Gena, P., Liquori, G. E., Cavalier, A., Thomas, D., and Svelto, M. (2005) J. Biol.	Water	62-67	aquaporin 8	Mus musculus	105-109
16756322-5	2006	This is consistent with a restriction of possible conformations in the disulfide-containing mutant and a reduction of average water-exposed nonpolar surface area in the free state, resulting in a smaller conformational entropy penalty, but also a smaller change in surface area, for binding of mutant compared to wild-type Z(SPA)(-)(1).	Water	126-131	signal-induced proliferation-associated 1	Homo sapiens	323-335
16925519-3	2006	The approach called SPAM (Solubility, Purity and Aggregation of the Molecule) Filter requires the acquisition of a 1D reference spectrum, a WaterLOGSY spectrum and/or a selective longitudinal relaxation filter spectrum for the identified hits dissolved in aqueous solution and in the presence of a water soluble reference molecule.	Water	298-303	eyes shut homolog	Homo sapiens	20-24
16899371-7	2006	4-1BB-mediated suppression of EAU was reversed by the pharmacological IDO inhibitor, 1-methyl-tryptophan (1-MT).	Water	30-33	indoleamine 2,3-dioxygenase 1	Homo sapiens	70-73
16622589-3	2006	The rather conservative behavior of Gd(ant) in surface and ground water documents in the present case the presence of sewage water in the surface water cycle.	Water	66-71	solute carrier family 25 member 6	Homo sapiens	36-43
16622589-3	2006	The rather conservative behavior of Gd(ant) in surface and ground water documents in the present case the presence of sewage water in the surface water cycle.	Water	125-130	solute carrier family 25 member 6	Homo sapiens	36-43
16622589-3	2006	The rather conservative behavior of Gd(ant) in surface and ground water documents in the present case the presence of sewage water in the surface water cycle.	Water	125-130	solute carrier family 25 member 6	Homo sapiens	36-43
16683800-4	2006	According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, solvation facilitates the transition of the chelating nitrate ligand to a eta1-bonding mode: the free energy of UO2(eta2-NO3)(eta1-NO3)(OH2)2 relative to the bis-chelating minimum drops from 3.9 kcal/mol in vacuo to 1.4 kcal/mol in water.	Water	335-340	secreted phosphoprotein 1	Homo sapiens	177-181
16651733-1	2006	Aquaporin 3 (AQP3), a membrane protein, is known to permeabilize water and other small molecules such as glycerol and urea and is localized in the bowel, skin, kidney, and erythrocytes.	Water	65-70	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
16651733-1	2006	Aquaporin 3 (AQP3), a membrane protein, is known to permeabilize water and other small molecules such as glycerol and urea and is localized in the bowel, skin, kidney, and erythrocytes.	Water	65-70	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
16704192-0	2006	Fast water-exchange Gd3+-(DO3A-like) complex functionalized with aza-15-crown-5 showing prolonged residence lifetime in vivo.	Water	5-10	GRDX	Homo sapiens	20-23
16704192-1	2006	A bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k(ex) = 3.1 x 10(7) s(-1)) and low acute cytotoxicity.	Water	166-171	GRDX	Homo sapiens	15-18
16733636-1	2006	This paper deals with the interaction between zein (the main protein component of corn grain) and water.	Water	98-103	zein	Zea mays	46-50
16733636-4	2006	In particular, imbibition measurements of a pure-water drop deposited onto a zein pill were performed.	Water	49-54	zein	Zea mays	77-81
16713493-3	2006	Mice lacking functional AQP2, AQP3, or AQP4 manifest various degrees of nephrogenic diabetes insipidus resulting from reduced collecting duct water permeability.	Water	142-147	aquaporin 2	Mus musculus	24-28
16713495-2	2006	Patients with hereditary NDI bearing mutations in AVPR2, the gene coding for the arginine vasopressin 2 receptor, or in AQP2, the gene coding for the vasopressin-sensitive water channel, have a pure NDI phenotype with loss of water, but normal conservation of sodium, potassium, chloride, and calcium.	Water	172-177	aquaporin 2	Homo sapiens	120-124
16713495-2	2006	Patients with hereditary NDI bearing mutations in AVPR2, the gene coding for the arginine vasopressin 2 receptor, or in AQP2, the gene coding for the vasopressin-sensitive water channel, have a pure NDI phenotype with loss of water, but normal conservation of sodium, potassium, chloride, and calcium.	Water	226-231	aquaporin 2	Homo sapiens	120-124
16585507-3	2006	The results indicate that the timescale of motion for residual water molecules on the biocatalyst, (tau(c))(D(2)O), in hexane decreased from 65 ns (salt-free) to 0.58 ns (98% CsF) as (k(cat)/K(M))(app) of the biocatalyst preparation increased from 0.092 s(-1) x M(-1) (salt-free) to 1,140 s(-1) x M(-1) (98% CsF).	Water	63-68	colony stimulating factor 2	Homo sapiens	175-178
16585507-3	2006	The results indicate that the timescale of motion for residual water molecules on the biocatalyst, (tau(c))(D(2)O), in hexane decreased from 65 ns (salt-free) to 0.58 ns (98% CsF) as (k(cat)/K(M))(app) of the biocatalyst preparation increased from 0.092 s(-1) x M(-1) (salt-free) to 1,140 s(-1) x M(-1) (98% CsF).	Water	63-68	colony stimulating factor 2	Homo sapiens	308-311
16570991-4	2006	For the H2O-CCl4 interface, though, there was a compensation between these strong hydrogen bonds and short to moderate ranged repulsion between iodide and CCl4.	Water	8-11	C-C motif chemokine ligand 4	Homo sapiens	12-16
16570991-4	2006	For the H2O-CCl4 interface, though, there was a compensation between these strong hydrogen bonds and short to moderate ranged repulsion between iodide and CCl4.	Water	8-11	C-C motif chemokine ligand 4	Homo sapiens	155-159
16798777-1	2006	The plasma membrane of skeletal muscles contains water channels such as aquaporin 4 (AQP4), aquaporin 3 (AQP3) and aquaporin 7 (AQP7).	Water	49-54	aquaporin 3 (Gill blood group)	Rattus norvegicus	105-109
16608395-9	2006	Transgenic mice grew faster and the increased growth caused by tNOX overexpression was blocked by EGCg in the drinking water.	Water	119-124	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	63-67
16343773-0	2006	RANTES, MDC and SDF-1alpha, prevent the HIVgp120-induced food and water intake decrease in rats.	Water	66-71	C-C motif chemokine ligand 22	Rattus norvegicus	8-11
16515860-0	2006	Low-resolution 1H spin-spin relaxation of n-decane/water emulsions stabilized by beta-casein.	Water	51-56	casein beta	Homo sapiens	81-92
16515860-1	2006	A low-resolution 1H NMR relaxometry study on the dynamics of an n-decane/water emulsion stabilized by beta-casein is presented.	Water	73-78	casein beta	Homo sapiens	102-113
16515860-5	2006	beta-Casein molecules displayed a prevalent population with significantly decreased mobility as compared to the free protein in solution, which is in accordance with the protein location at the oil/water interface.	Water	198-203	casein beta	Homo sapiens	0-11
16514440-1	2006	Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional coupling and large contributions from second sphere water molecules.	Water	299-304	complement C4A (Rodgers blood group)	Homo sapiens	12-15
16219438-2	2006	This study was designed to determine the effect of Polygonum multiflorum Thunb water extract (PWE) on Abeta25-35-induced cognitive deficits and oxidative stress in mice.	Water	79-84	natriuretic peptide receptor 2	Mus musculus	94-97
16503639-2	2006	The analysis of O-D stretching vibrations in D(2)O revealed that there are more internal water molecules near the retinal chromophore in squid rhodopsin than in bovine rhodopsin.	Water	89-94	rhodopsin	Bos taurus	143-152
16503639-3	2006	Among nine O-D stretching vibrations of water in squid rhodopsin, eight peaks are identical between rhodopsin and 9-cis-rhodopsin (Iso).	Water	40-45	rhodopsin	Bos taurus	55-64
16503639-3	2006	Among nine O-D stretching vibrations of water in squid rhodopsin, eight peaks are identical between rhodopsin and 9-cis-rhodopsin (Iso).	Water	40-45	rhodopsin	Bos taurus	100-109
16503639-3	2006	Among nine O-D stretching vibrations of water in squid rhodopsin, eight peaks are identical between rhodopsin and 9-cis-rhodopsin (Iso).	Water	40-45	rhodopsin	Bos taurus	100-109
16503639-4	2006	On the other hand, the isomer-specific O-D stretch of water was observed for rhodopsin (2451 cm(-)(1)) and Iso (2382 cm(-)(1)).	Water	54-59	rhodopsin	Bos taurus	77-86
16503639-7	2006	Most vibrational bands in the X-D stretch region originate from water O-D or the Schiff base N-D stretches, suggesting that the hydrogen bonding network in the Schiff base region of squid rhodopsin is composed of only water molecules.	Water	64-69	rhodopsin	Bos taurus	188-197
16503639-7	2006	Most vibrational bands in the X-D stretch region originate from water O-D or the Schiff base N-D stretches, suggesting that the hydrogen bonding network in the Schiff base region of squid rhodopsin is composed of only water molecules.	Water	218-223	rhodopsin	Bos taurus	188-197
16494440-1	2006	The structures, stabilities, thermodynamic quantities, dissociation energies, infrared spectra, and electronic properties of CsF hydrated by water molecules are investigated by using density functional theory, Moller-Plesset second-order perturbation theory (MP2), coupled cluster theory with singles, doubles, and perturbative triples excitations (CCSD(T)), and ab initio molecular dynamic (AIMD) simulations.	Water	141-146	colony stimulating factor 2	Homo sapiens	125-128
16494440-1	2006	The structures, stabilities, thermodynamic quantities, dissociation energies, infrared spectra, and electronic properties of CsF hydrated by water molecules are investigated by using density functional theory, Moller-Plesset second-order perturbation theory (MP2), coupled cluster theory with singles, doubles, and perturbative triples excitations (CCSD(T)), and ab initio molecular dynamic (AIMD) simulations.	Water	141-146	tryptase pseudogene 1	Homo sapiens	259-262
16289668-2	2006	After the freeze-drying of tap water samples, determination by liquid scintillation counting can be applied utilizing alpha/beta separation.	Water	31-36	filamin B	Homo sapiens	27-30
16478451-6	2006	These assays were applied to a stratified water column in the Sargasso Sea.	Water	42-47	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	71-74
16546977-10	2006	Thus, the study shows that water-soluble inhibitors of thioredoxin reductase-1, such as PX-916, can block thioredoxin-1 signaling in tumors producing marked inhibition of tumor growth.	Water	27-32	thioredoxin	Homo sapiens	55-66
16537998-5	2006	In Water-fed groups, treatment with BPA resulted in lower titers of total IgE (P&lt;0.01) and higher levels IgG2a (P&lt;0.05) followed by a higher IFN-gamma (P&lt;0.05) and IL-12 (P&lt;0.05) with an intact IL-4.	Water	3-8	interleukin 4	Mus musculus	206-210
16353088-0	2006	A water-soluble hexa-peri-hexabenzocoronene: synthesis, self-assembly and role as template for porous silica with aligned nanochannels.	Water	2-7	hexosaminidase subunit alpha	Homo sapiens	16-20
16353088-1	2006	A water-soluble hexa-peri-hexabenzocoronene was prepared and shown to undergo ordered columnar self-assembly either in water solution or bulk and therefore served as template for the fabrication of porous silica with aligned nanochannels.	Water	2-7	hexosaminidase subunit alpha	Homo sapiens	16-20
16353088-1	2006	A water-soluble hexa-peri-hexabenzocoronene was prepared and shown to undergo ordered columnar self-assembly either in water solution or bulk and therefore served as template for the fabrication of porous silica with aligned nanochannels.	Water	119-124	hexosaminidase subunit alpha	Homo sapiens	16-20
16671476-2	2006	Since evidence indicates that brain aquaporin-4 (AQP4) water channels are modulated by vasopressin V1a receptors, we examined the edema-reducing properties of the selective V1a receptor antagonist, SR49059, following middle cerebral artery occlusion (MCAO).	Water	55-60	aquaporin 4	Rattus norvegicus	36-47
16671476-2	2006	Since evidence indicates that brain aquaporin-4 (AQP4) water channels are modulated by vasopressin V1a receptors, we examined the edema-reducing properties of the selective V1a receptor antagonist, SR49059, following middle cerebral artery occlusion (MCAO).	Water	55-60	aquaporin 4	Rattus norvegicus	49-53
16671492-1	2006	The protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), is known to interact with aquaporin-4 (AQP4), a water-selective transporting protein abundant in astrocytes and ependymal cells, that has been found to decrease osmotically-induced swelling.	Water	119-124	aquaporin 4	Rattus norvegicus	97-108
16671492-1	2006	The protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), is known to interact with aquaporin-4 (AQP4), a water-selective transporting protein abundant in astrocytes and ependymal cells, that has been found to decrease osmotically-induced swelling.	Water	119-124	aquaporin 4	Rattus norvegicus	110-114
16091580-5	2006	Utilizing beta-Gal activity assays, we further show that within the kidney, the beta-Gal transgene can be regulated by both water restriction and glucocorticoids, similar to the regulation of the endogenous UT-A gene.	Water	124-129	galactosidase, beta 1	Mus musculus	80-88
16200643-0	2006	Activity and plasticity in the CA1, the dentate gyrus, and the amygdala following controllable vs. uncontrollable water stress.	Water	114-119	carbonic anhydrase 1	Rattus norvegicus	31-34
16876294-3	2006	A significant difference in intermediate water (137)Cs activities in the 500-2000m depth was observed between the Sulu and South China Seas, i.e., the (137)Cs activities in the Sulu Sea were remarkably higher than those in the South China Sea.	Water	41-46	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	135-138
17294658-6	2006	Urea restrains the precipitation of Co2(SO3)3 by oxidizing SO3(2-) to SO4(-) as CoSO4 is more soluble in water.	Water	105-110	complement C2	Homo sapiens	36-39
16357496-11	2006	The mean maximum lumbar CSF pressure documented in this cohort was 26 cm of water in adults and 25.3 in children.	Water	76-81	colony stimulating factor 2	Homo sapiens	24-27
16322574-2	2006	Biochemical studies of human beta-2 microglobulin (beta2M) have shown that its transition from a water-soluble protein to insoluble aggregates can be triggered by low pH.	Water	97-102	beta-2-microglobulin	Homo sapiens	29-49
16322574-2	2006	Biochemical studies of human beta-2 microglobulin (beta2M) have shown that its transition from a water-soluble protein to insoluble aggregates can be triggered by low pH.	Water	97-102	beta-2-microglobulin	Homo sapiens	51-57
16464787-3	2006	It is unknown whether aquaporin-2 (AQP2) renal water channels are involved in this compensatory reabsorption.	Water	47-52	aquaporin 2	Homo sapiens	22-33
16464787-3	2006	It is unknown whether aquaporin-2 (AQP2) renal water channels are involved in this compensatory reabsorption.	Water	47-52	aquaporin 2	Homo sapiens	35-39
16376964-3	2006	In case of eight different kinds of commercial AC in pure water, the amount adsorbed at equilibrium concentration of 1 microg/L was in the range of 25.6-73.5mg/g for E1 and 21.3-67.6 mg/g for E2.	Water	58-63	small nucleolar RNA, H/ACA box 73A	Homo sapiens	166-175
16715705-1	2006	It was investigated whether preliminary administration of water with reduced Deuterium content may modify the inhibitory effect of the water given to BDF1 and CDA mice on the day of tumor transplantation.	Water	58-63	cytidine deaminase	Mus musculus	159-162
16343610-1	2005	A purified polysaccharide ACDP-2 was isolated from water extract of the stems of Cistanche deserticola.	Water	51-56	cyclin M2	Mus musculus	26-32
16246107-0	2005	Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.	Water	65-70	aquaporin 2	Homo sapiens	99-110
16150901-2	2005	Short-term control of water permeability occurs via vesicular trafficking of AQP2 and long-term control through changes in the abundance of AQP2 and AQP3 water channels.	Water	22-27	aquaporin 2	Homo sapiens	140-144
16150901-2	2005	Short-term control of water permeability occurs via vesicular trafficking of AQP2 and long-term control through changes in the abundance of AQP2 and AQP3 water channels.	Water	22-27	aquaporin 3 (Gill blood group)	Homo sapiens	149-153
16150901-2	2005	Short-term control of water permeability occurs via vesicular trafficking of AQP2 and long-term control through changes in the abundance of AQP2 and AQP3 water channels.	Water	154-159	aquaporin 3 (Gill blood group)	Homo sapiens	149-153
16166214-5	2005	The response to hypoxia appears to involve reactive oxygen species, because treatment with H(2)O(2) results in a dose-dependent decrease of IGFBP-1 mRNA levels under venous pO(2), whereas IGFBP-1 mRNA expression under arterial pO(2) was not affected.	Water	91-96	insulin-like growth factor binding protein 1	Rattus norvegicus	140-147
16382951-5	2005	This study examined the effectiveness of commercial zerovalent iron to remove two viruses, phiX174 and MS-2, from water.	Water	114-119	MS2	Homo sapiens	103-107
16125889-2	2005	Water extracts, a 70% methanol (MeOH) extract and an ethyl acetate (EtOAc) soluble fraction (III) from DJW inhibited platelet-activating factor (PAF)-induced platelet aggregation in vitro and in vivo assays.	Water	0-5	PCNA clamp associated factor	Homo sapiens	145-148
16307773-2	2005	The purpose of this work was to assess the feasibility of this technique for drinking water disinfection and evaluate the effects of selected impurities, found in fresh water, and common parameters on inactivation of the coliphage MS-2 with the silver-UV process.	Water	86-91	MS2	Homo sapiens	231-235
16307773-2	2005	The purpose of this work was to assess the feasibility of this technique for drinking water disinfection and evaluate the effects of selected impurities, found in fresh water, and common parameters on inactivation of the coliphage MS-2 with the silver-UV process.	Water	169-174	MS2	Homo sapiens	231-235
16246454-1	2005	Aquaporin (AQP) 4 is a member of the AQP gene family of water-selective transport proteins.	Water	56-61	aquaporin 4	Gallus gallus	0-17
16480633-13	2005	CONCLUSION: Nonpeptide NK1-receptor antagonist L-703, 606 was able to mitigate the vascular permeability and reduce tissue water content in peri-wound and jejunal tissues.	Water	123-128	tachykinin receptor 1	Rattus norvegicus	23-35
16833288-2	2005	Strong correlations are found between NMA geometry and the amide frequency fluctuations calculated using this Hamiltonian together with the fluctuating solvent electric field obtained from the MD simulations in TIP3 water.	Water	216-221	suppressor of cytokine signaling 1	Homo sapiens	211-215
16563128-1	2006	BACKGROUND INFORMATION: Aquaporin 2 (AQP2) plays an important, VP (vasopressin)-regulated role in water reabsorption by the kidney.	Water	98-103	aquaporin 2	Homo sapiens	24-35
16563128-1	2006	BACKGROUND INFORMATION: Aquaporin 2 (AQP2) plays an important, VP (vasopressin)-regulated role in water reabsorption by the kidney.	Water	98-103	aquaporin 2	Homo sapiens	37-41
16225961-0	2006	Copper binding properties of a tau peptide associated with Alzheimer"s disease studied by CD, NMR, and MALDI-TOF MS. We have previously reported the copper binding properties of R3 peptide (residues 318-335: VTSKCGSLGNIHHKPGGG, according to the longest tau protein) derived from the third repeat microtubule-binding domain of water-soluble tau protein.	Water	326-331	microtubule associated protein tau	Homo sapiens	31-34
16505377-7	2006	The data support the proposed CD3zeta peptide structure, and the simulations point to the structural disorder of water and lipid head-groups as the main source of inhomogeneous broadening.	Water	113-118	CD247 molecule	Homo sapiens	30-37
28526298-1	2017	Aquaporin- (AQP) 3, a water and glycerol channel, plays an important role in epidermal function, with studies showing its involvement in keratinocyte proliferation, differentiation, and migration and in epidermal wound healing and barrier repair.	Water	22-27	aquaporin 3 (Gill blood group)	Homo sapiens	0-18
16458491-1	2006	When animals learn hippocampus-dependent associative and spatial tasks such as trace eyeblink conditioning and the water maze, CA1 hippocampal neurons become more excitable as a result of reductions in the post-burst, slow afterhyperpolarization.	Water	115-120	carbonic anhydrase 1	Mus musculus	127-130
16260841-0	2005	Coupled K+-water flux through the HERG potassium channel measured by an osmotic pulse method.	Water	11-16	potassium voltage-gated channel subfamily H member 2	Homo sapiens	34-38
16277476-5	2005	The generation of a dispersed Ag2O sol and the observed shape selectivity are both explained by a two-step mechanism involving the anodic dissolution of silver metal, Ag0 --&gt; Ag+(aq) + 1e-, followed by the precipitation of Ag2O particles, 2Ag+ + 2OH- --&gt; Ag2O(s) + H2O.	Water	271-274	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	30-33
28624548-5	2017	11beta-HSD2 acts as a "guardian" enzyme protecting the mineralocorticoid receptor from excess cortisol, preventing sodium and water retention in the normotensive state.	Water	126-131	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	0-11
16223878-3	2005	The soluble alpha-syn monomer exchanges its amide hydrogens with water hydrogens at random coil rates, consistent with its natively unstructured condition.	Water	65-70	synuclein alpha	Homo sapiens	12-21
16604834-3	2006	Bacterial indicator data indicate that exceedances of the water quality objectives are temporally sporadic, geographically limited and most commonly occur during the time of the year and/or in areas of the bay where the REC-1 use is low or non-existent.	Water	58-63	RAD1 checkpoint DNA exonuclease	Homo sapiens	220-225
28808020-3	2017	By contrast, in epithelial cells from the colon, stomach, and kidney, KCNE3 coassembles with KCNQ1 to form K+ channels that are voltage-independent K+ channels in the physiological voltage range and important for controlling water and salt secretion and absorption.	Water	225-230	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	93-98
16342058-8	2006	Synaptic changes found in the CA1 shortly after water maze training suggest a possible participation of the hippocampus in the acquisition of nonspatial tasks together with a role in the short-term consolidation of spatial memory.	Water	48-53	carbonic anhydrase 1	Rattus norvegicus	30-33
16212380-3	2005	Crystallographic results show binding of the acyclic quasiplanar water tetramer [H4L(H2O)4](I)4.2.57H2O (1) in a tetraprotonated cryptand L having an iodide counteranion, where two water molecules reside inside the two tren-based cavity, bridged by a third water molecule, and a fourth external water molecule is hydrogen bonded to the bridged water molecule.	Water	65-70	H4 clustered histone 7	Homo sapiens	81-84
16212380-3	2005	Crystallographic results show binding of the acyclic quasiplanar water tetramer [H4L(H2O)4](I)4.2.57H2O (1) in a tetraprotonated cryptand L having an iodide counteranion, where two water molecules reside inside the two tren-based cavity, bridged by a third water molecule, and a fourth external water molecule is hydrogen bonded to the bridged water molecule.	Water	181-186	H4 clustered histone 7	Homo sapiens	81-84
16212380-3	2005	Crystallographic results show binding of the acyclic quasiplanar water tetramer [H4L(H2O)4](I)4.2.57H2O (1) in a tetraprotonated cryptand L having an iodide counteranion, where two water molecules reside inside the two tren-based cavity, bridged by a third water molecule, and a fourth external water molecule is hydrogen bonded to the bridged water molecule.	Water	181-186	H4 clustered histone 7	Homo sapiens	81-84
28817279-6	2017	The electrocatalysis of water oxidation by FeCePH films on FTO-coated glass is studied in neutral pH conditions.	Water	24-29	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	59-62
16212380-3	2005	Crystallographic results show binding of the acyclic quasiplanar water tetramer [H4L(H2O)4](I)4.2.57H2O (1) in a tetraprotonated cryptand L having an iodide counteranion, where two water molecules reside inside the two tren-based cavity, bridged by a third water molecule, and a fourth external water molecule is hydrogen bonded to the bridged water molecule.	Water	181-186	H4 clustered histone 7	Homo sapiens	81-84
16212380-3	2005	Crystallographic results show binding of the acyclic quasiplanar water tetramer [H4L(H2O)4](I)4.2.57H2O (1) in a tetraprotonated cryptand L having an iodide counteranion, where two water molecules reside inside the two tren-based cavity, bridged by a third water molecule, and a fourth external water molecule is hydrogen bonded to the bridged water molecule.	Water	181-186	H4 clustered histone 7	Homo sapiens	81-84
29745556-1	2017	With the oxidative damage model established in rat myocardial cells by hydrogen peroxide (H 2O 2), the expression of myocardin and nuclear factor erythroid 2-related factor 2 (Nrf2) during oxidative damage and effect of myocardin on Nrf2 were preliminarily explored.	Water	90-94	myocardin	Rattus norvegicus	117-126
16210649-3	2005	In this paper we report on studies examining how the ROS hydrogen peroxide (H(2)O(2)) affects the production of MMP-1, COX-2, and PGE(2).	Water	76-81	matrix metallopeptidase 1	Homo sapiens	112-117
28814806-4	2017	In addition, we also provide observed evidence that it is quite likely the enhancement of the wintertime greenhouse effect caused by water vapor and cloudiness has advanced the time of onset of ice melting in mid-May through inhibiting sea-ice refreezing in the winter and accelerating the pre-melting process in the spring, and in turn triggered the positive sea-ice albedo feedback process and accelerated the sea ice melting in the summer.	Water	133-138	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	236-239
16040755-4	2005	Because the latter presents a continuous amphipathic groove and is regulated by binding certain fatty acids, we compared the properties of BUBR1(1-204) and TPR-PP5(16-181) at air/water interfaces and found that both proteins exhibited a similar surface activity and formed stable, rigid monolayers.	Water	179-184	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	139-144
16580864-5	2006	In oocytes expressing Rhcg, exposure to bath [NH4+] of 2.5-20 mM induced inward currents that were slightly more than those in H2O-injected (control) oocytes.	Water	127-130	Rh family C glycoprotein S homeolog	Xenopus laevis	22-26
16471901-6	2006	For understanding the inhibitory mechanism, extensive molecular docking, molecular dynamics simulations, and binding free-energy calculations have been performed in this study to predict the most favorable structures of CD4-EGCG, gp120-CD4, and gp120-CD4-EGCG binding complexes in water.	Water	281-286	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	245-250
16179736-4	2005	Results from the study demonstrate that water channels AQP1 and AQP6, and the heterotrimeric Go protein are associated with SVs and participate in their swelling.	Water	40-45	aquaporin 6	Homo sapiens	64-68
28814806-4	2017	In addition, we also provide observed evidence that it is quite likely the enhancement of the wintertime greenhouse effect caused by water vapor and cloudiness has advanced the time of onset of ice melting in mid-May through inhibiting sea-ice refreezing in the winter and accelerating the pre-melting process in the spring, and in turn triggered the positive sea-ice albedo feedback process and accelerated the sea ice melting in the summer.	Water	133-138	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	360-363
28814806-4	2017	In addition, we also provide observed evidence that it is quite likely the enhancement of the wintertime greenhouse effect caused by water vapor and cloudiness has advanced the time of onset of ice melting in mid-May through inhibiting sea-ice refreezing in the winter and accelerating the pre-melting process in the spring, and in turn triggered the positive sea-ice albedo feedback process and accelerated the sea ice melting in the summer.	Water	133-138	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	360-363
28521981-3	2017	The solvent vapor annealing induced self-organizations of the BCP into different phases depending on phiMH and the weight fraction of THF/H2O.	Water	138-141	opsin 1, short wave sensitive	Homo sapiens	62-65
16093448-3	2005	Patients who have congenital NDI and bear mutations in the AVPR2 or AQP2 genes have a "pure" NDI phenotype with loss of water but normal conservation of sodium, potassium, chloride, and calcium.	Water	120-125	aquaporin 2	Homo sapiens	68-72
16834185-3	2005	For the water-indole system, the more elaborate MP2 and MPW1B95 methods yield only one minimum with a hydrogen bond to the pyrrole part and weak secondary interactions to the phenyl ring, in agreement with a recent criticism by Van Mourik (Chem.	Water	8-13	tryptase pseudogene 1	Homo sapiens	48-51
16174867-11	2006	The increased targeting of ENaC and AQP2 likely represents direct or compensatory effects to increase sodium and water reabsorption and to prevent volume depletion in response to prolonged ANP infusion.	Water	113-118	aquaporin 2	Rattus norvegicus	36-40
16183122-8	2006	Methanol modifier (BDH, for pesticide residue analysis, 10 mL) was added to water sample for better extraction.	Water	76-81	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	19-22
28521981-4	2017	BCPs with relatively higher OMH, MH-b-PMMA3k (phiMH=0.27) and MH-b-PMMA5k (phiMH=0.16) self-organized into lamellar phases while the BCP sample with relatively lower phiMH, MH-b-PMMA9k (phiMH=0.10), self-organized into cylindrical phase by using THF/H2O=1/4 (w/w).	Water	250-253	opsin 1, short wave sensitive	Homo sapiens	0-3
28431257-5	2017	With this surface modification, the hydrophilicity of membranes improved significantly and the pure water flux increased compared to the unmodified PEK-COOH membrane.	Water	100-105	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	148-151
16826903-0	2006	[Spectra analysis of [MnHg(SCN)4 (H2O)2 x 2C4H9NO (MMTWD) crystals].	Water	34-37	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	27-32
16123124-2	2005	Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates.	Water	90-95	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	0-34
16321251-0	2005	[Expression of aquaporin 2, a water channel, in human endometrium during the menstrual cycle].	Water	30-35	aquaporin 2	Homo sapiens	15-26
16374796-8	2006	In water-deprived rats (n=4), numerous VGLUT2 mRNA-positive PVH neurons retrogradely labeled from the ipsilateral RVLM with CTB were c-Fos-ir (16-40%, depending on PVH region).	Water	3-8	solute carrier family 17 member 6	Rattus norvegicus	39-45
28749508-1	2017	Individual airborne sea spray aerosol (SSA) particles show diversity in their morphologies and water uptake properties that are highly dependent on the biological, chemical, and physical processes within the sea subsurface and the sea surface microlayer.	Water	95-100	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	20-23
16374796-10	2006	Most (94% +/- 4%) RVLM-projecting PVH neurons activated by water deprivation contained VGLUT2 mRNA.	Water	59-64	solute carrier family 17 member 6	Rattus norvegicus	87-93
16374801-9	2006	Consistent with this speculation, nuclear CINAP levels in the PVN were higher in hypertonic saline-treated mice than those who drank water.	Water	133-138	TSPY-like 2	Mus musculus	42-47
15859948-2	2005	This hormone induces an increase in water permeability due to the translocation of AQP2 (aquaporin 2) from the intracellular vesicles to the apical membrane of principal cells.	Water	36-41	aquaporin 2	Homo sapiens	83-87
15859948-2	2005	This hormone induces an increase in water permeability due to the translocation of AQP2 (aquaporin 2) from the intracellular vesicles to the apical membrane of principal cells.	Water	36-41	aquaporin 2	Homo sapiens	89-100
15859948-12	2005	CONCLUSIONS: These results suggest that increases in the osmotic water permeability due to the expression of AQP2 are critical for a rapid activation of regulatory volume decrease mechanisms, which would be linked to cystic fibrosis transmembrane conductance regulator and to barium-sensitive potassium channels.	Water	65-70	aquaporin 2	Homo sapiens	109-113
15927620-3	2005	The chemical properties of the aluminosilicate, such as affinity for water and other reactants, were found to affect the photocatalytic property of the CdS nanoparticles immobilized.	Water	69-74	CDP-diacylglycerol synthase 1	Homo sapiens	152-155
16316632-0	2006	Characterization of multimetric variants of ubiquitin carboxyl-terminal hydrolase L1 in water by small-angle neutron scattering.	Water	88-93	ubiquitin C-terminal hydrolase L1	Homo sapiens	44-84
28475982-5	2017	The sensor is applied in real water samples with results comparing favorably with those obtained from ICP-OES (for Cd2+) and HPLC (for S2-).	Water	30-35	CD2 molecule	Homo sapiens	115-118
16081834-4	2005	PAR2-AP, but not PAR1-AP or PAR4-AP, caused a sharp increase in lung endothelial and epithelial permeability to protein, extravascular lung water, and airway tone.	Water	140-145	pulmonary adenoma resistance 2	Mus musculus	0-4
28691816-1	2017	Mechanisms of excited-state intramolecular proton transfer (ESIPT) of 1,2-dihydroxyanthraquinone (ALR) in ethanol solvent and binary solvent of water and ethanol are investigated using the density functional theory and time-dependent density functional theory.	Water	144-149	growth factor, augmenter of liver regeneration	Homo sapiens	98-101
16229564-1	2005	Water clusters (H2On and (D2On (n&lt;or=15) are produced by supersonic expansion and then pick up an additional heavy or light water molecule, respectively, or an amino-acid molecule (glycine or tryptophan).	Water	0-5	protein interacting with PRKCA 1	Homo sapiens	90-94
16229564-1	2005	Water clusters (H2On and (D2On (n&lt;or=15) are produced by supersonic expansion and then pick up an additional heavy or light water molecule, respectively, or an amino-acid molecule (glycine or tryptophan).	Water	127-132	protein interacting with PRKCA 1	Homo sapiens	90-94
16422608-2	2006	In addition the infrared spectrum of the complex between p-D2 and H2O in solid o-D2 has been studied.	Water	66-69	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	57-61
28691816-4	2017	The absorption and fluorescence spectra of ALR in binary solvent with different water percentage are obtained and demonstrate the inhibition effect of water on the ESIPT process, which are consistent with the experimentally observation.	Water	80-85	growth factor, augmenter of liver regeneration	Homo sapiens	43-46
28691816-4	2017	The absorption and fluorescence spectra of ALR in binary solvent with different water percentage are obtained and demonstrate the inhibition effect of water on the ESIPT process, which are consistent with the experimentally observation.	Water	151-156	growth factor, augmenter of liver regeneration	Homo sapiens	43-46
16392869-1	2006	Accurate anharmonic experimental vibrational frequencies for water clusters consisting of 2-5 water molecules have been predicted on the basis of comparing different methods with MP2/aug-cc-pVTZ calculated and experimental anharmonic frequencies.	Water	61-66	tryptase pseudogene 1	Homo sapiens	179-182
16009937-2	2005	Aquaporin 7 (AQP7), a member of aquaglyceroporins, is known to permeabilize glycerol and water.	Water	89-94	aquaporin 7	Mus musculus	0-11
28691816-5	2017	Furthermore, more water molecules are considered near the carbonyl group and hydroxyl group related to the intramolecular proton transfer to form intermolecular hydrated hydrogen bond with ALR for clarifying the block mechanism of water on ESIPT.	Water	18-23	growth factor, augmenter of liver regeneration	Homo sapiens	189-192
16009937-2	2005	Aquaporin 7 (AQP7), a member of aquaglyceroporins, is known to permeabilize glycerol and water.	Water	89-94	aquaporin 7	Mus musculus	13-17
16392869-2	2006	The combination of using HF/6-31G* scaled frequencies for intramolecular modes and anharmonic frequencies for intermolecular modes gives excellent agreement with experiment for the water dimer and trimer and are as good as the expensive anharmonic MP2 calculations.	Water	181-186	tryptase pseudogene 1	Homo sapiens	248-251
28691816-5	2017	Furthermore, more water molecules are considered near the carbonyl group and hydroxyl group related to the intramolecular proton transfer to form intermolecular hydrated hydrogen bond with ALR for clarifying the block mechanism of water on ESIPT.	Water	231-236	growth factor, augmenter of liver regeneration	Homo sapiens	189-192
28691816-7	2017	The results show that the interrupt role of water on the ESIPT originated from the forming of hydrated hydrogen bond between the carbonyl oxygen atom and the water molecule, which weakens the intramolecular hydrogen bond associated with proton transfer, increases the energy barrier of ESIPT, and thus precludes the transition of ALR-E to ALR-K in the excited state.	Water	44-49	growth factor, augmenter of liver regeneration	Homo sapiens	330-333
28691816-7	2017	The results show that the interrupt role of water on the ESIPT originated from the forming of hydrated hydrogen bond between the carbonyl oxygen atom and the water molecule, which weakens the intramolecular hydrogen bond associated with proton transfer, increases the energy barrier of ESIPT, and thus precludes the transition of ALR-E to ALR-K in the excited state.	Water	44-49	growth factor, augmenter of liver regeneration	Homo sapiens	339-342
17193595-0	2006	Catalytic effects of apoferritin interior surface residues on water proton exchange in lanthanide complexes.	Water	62-67	ferritin heavy chain 1	Homo sapiens	21-32
28691816-7	2017	The results show that the interrupt role of water on the ESIPT originated from the forming of hydrated hydrogen bond between the carbonyl oxygen atom and the water molecule, which weakens the intramolecular hydrogen bond associated with proton transfer, increases the energy barrier of ESIPT, and thus precludes the transition of ALR-E to ALR-K in the excited state.	Water	158-163	growth factor, augmenter of liver regeneration	Homo sapiens	330-333
28691816-7	2017	The results show that the interrupt role of water on the ESIPT originated from the forming of hydrated hydrogen bond between the carbonyl oxygen atom and the water molecule, which weakens the intramolecular hydrogen bond associated with proton transfer, increases the energy barrier of ESIPT, and thus precludes the transition of ALR-E to ALR-K in the excited state.	Water	158-163	growth factor, augmenter of liver regeneration	Homo sapiens	339-342
28322951-6	2017	Results demonstrate that positive Mb colloids at pH 4.5, having more% of entrained water stabilize the collagen fibrils (pH 7.5) around them.	Water	83-88	myoglobin	Homo sapiens	34-36
16340664-4	2006	Endothelin-1 in vitro can inhibit sodium or water transport in the collecting duct and thick ascending limb through autocrine pathways.	Water	44-49	endothelin 1	Mus musculus	0-12
16340664-11	2006	SUMMARY: Medullary endothelin-1 regulates renal sodium and water transport and medullary blood flow.	Water	59-64	endothelin 1	Mus musculus	19-31
27286908-7	2017	Episodic events of the settling of biological particles from the surface layer and the regeneration processes the deep layer control the 210Po removal in the water column of the South China Sea.	Water	158-163	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	190-193
16501855-9	2006	The gastric contents of MPO, TNF-alpha, IL-1beta, and CRO/CINC-1 were all increased after water-immersion stress and were reduced to almost normal levels by cilostazol.	Water	90-95	myeloperoxidase	Rattus norvegicus	24-27
16501855-9	2006	The gastric contents of MPO, TNF-alpha, IL-1beta, and CRO/CINC-1 were all increased after water-immersion stress and were reduced to almost normal levels by cilostazol.	Water	90-95	C-X-C motif chemokine ligand 1	Rattus norvegicus	58-64
28569330-4	2017	CC1 is found to be impermeable to water due to disconnected pores.	Water	34-39	C-C motif chemokine ligand 14	Homo sapiens	0-3
28569330-5	2017	With an interconnected tetrahedral pore network, CC3 and CC16 have an intermediate water permeability of 1-5 x 10-7 kg m (m2 h bar)-1.	Water	83-88	C-C motif chemokine ligand 14	Homo sapiens	49-52
28569330-5	2017	With an interconnected tetrahedral pore network, CC3 and CC16 have an intermediate water permeability of 1-5 x 10-7 kg m (m2 h bar)-1.	Water	83-88	secretoglobin family 1A member 1	Homo sapiens	57-61
28798666-8	2017	Furthermore, NLRP6-/- ICH mice exhibited significantly higher brain water contents (BMCs), proinflammatory cytokines, NF-kappaB activity and neurological deficit scores when compared with the wild type (WT) ICH mice.	Water	68-73	NLR family, pyrin domain containing 6	Mus musculus	13-18
16194553-7	2006	Pb isotopic ratios show that water entering the Irish Sea through St George"s Channel is significantly influenced by anthropogenic inputs prior to additional contamination by direct inputs to the Irish Sea.	Water	29-34	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	54-57
31457676-5	2017	Furthermore, the presence of a large number of isopropyl groups imparts hydrophobicity to Py-azo-COP, as confirmed by the increased adsorption of toluene compared to that of water in the pores of the COP.	Water	174-179	caspase recruitment domain family member 16	Homo sapiens	97-100
16133124-4	2005	We found that water deprivation leads to simultaneous activation of synthesis of VP and p53 and Bcl-2 apoptotic proteins in the mouse brain.	Water	14-19	transformation related protein 53, pseudogene	Mus musculus	88-91
31457676-5	2017	Furthermore, the presence of a large number of isopropyl groups imparts hydrophobicity to Py-azo-COP, as confirmed by the increased adsorption of toluene compared to that of water in the pores of the COP.	Water	174-179	caspase recruitment domain family member 16	Homo sapiens	200-203
16299340-1	2005	In vitro, Clostridium perfringens enterotoxin (CPE) binds to human ileal epithelium and induces morphological damage concurrently with reduced short-circuit current, transepithelial resistance, and net water absorption.	Water	202-207	cpe	Clostridium perfringens	10-45
28516279-5	2017	The prepared mGCB was firstly tested as an adsorbent for the extraction from surface water of 50 pollutants, including estrogens, perfluoroalkyl compounds, UV filters, and quinolones.	Water	85-90	natriuretic peptide receptor 2	Mus musculus	13-17
16299340-1	2005	In vitro, Clostridium perfringens enterotoxin (CPE) binds to human ileal epithelium and induces morphological damage concurrently with reduced short-circuit current, transepithelial resistance, and net water absorption.	Water	202-207	cpe	Clostridium perfringens	47-50
28868293-7	2017	Final water reabsorption is mediated by the aquaporin 2 (AQP2) water channels along the distal nephron, and it is under hormonal control.	Water	6-11	aquaporin 2	Homo sapiens	44-55
16165354-1	2005	The 7-carbamate groups of geldanamycin and its 17-(2-dimethylaminoethyl)amino-17-demethoxy derivative (17-DMAG) bind the N-terminal domain of Hsp90 by establishing a network of hydrogen bonds which involve four buried water molecules.	Water	218-223	heat shock protein 90 alpha family class A member 1	Homo sapiens	142-147
16323799-6	2005	Equally strong correlations were obtained when k(obs) was related to the summed concentration of protons and water reduced over an equivalent time interval at that same rhom.	Water	109-114	ras homolog family member D	Homo sapiens	169-173
28868293-7	2017	Final water reabsorption is mediated by the aquaporin 2 (AQP2) water channels along the distal nephron, and it is under hormonal control.	Water	6-11	aquaporin 2	Homo sapiens	57-61
28868293-7	2017	Final water reabsorption is mediated by the aquaporin 2 (AQP2) water channels along the distal nephron, and it is under hormonal control.	Water	63-68	aquaporin 2	Homo sapiens	44-55
16262308-1	2005	Applying poly(ethoxysiloxane) (a liquid non-water-soluble polymer that can be hydrolyzed and cross-linked by diluted acids) to an air/pH 1 water interface gave rise to thin homogeneous solid layers.	Water	139-144	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	134-138
28868293-7	2017	Final water reabsorption is mediated by the aquaporin 2 (AQP2) water channels along the distal nephron, and it is under hormonal control.	Water	63-68	aquaporin 2	Homo sapiens	57-61
28488384-0	2017	Water-Soluble Polymers with Strong Photoluminescence through an Eco-Friendly and Low-Cost Route.	Water	0-5	ciliogenesis associated kinase 1	Homo sapiens	64-67
16283763-0	2005	Calcium-induced changes to the molecular conformation and aggregate structure of beta-casein at the air-water interface.	Water	104-109	casein beta	Homo sapiens	81-92
16283763-1	2005	The influence of calcium on interactions of beta-casein at the air-water interface has been studied by several techniques, including interfacial rheology, atomic force microscopy (AFM), infrared reflectance-absorbance spectroscopy (IRRAS), and zeta potential measurements.	Water	67-72	casein beta	Homo sapiens	44-55
28488384-3	2017	Herein, through a novel, eco-friendly, and one-step route, PMV-derived PL polymers can be fabricated with the highest quantum yield of 87% among water-soluble nonconjugated PL polymers ever reported.	Water	145-150	ciliogenesis associated kinase 1	Homo sapiens	25-28
15975959-3	2005	Sequencing analysis of the p53 gene (exons 3 to 9) detected 88, 82 or 39 point mutations in 67, 70 or 29 patches from water, caffeine or tea treated mice, respectively.	Water	118-123	transformation related protein 53, pseudogene	Mus musculus	27-30
28478670-4	2017	We demonstrate that the relative energies from GEBF-MP2/CBS are in excellent agreement with those from GEBF-CCSD(T)/CBS for these water clusters.	Water	130-135	tryptase pseudogene 1	Homo sapiens	52-55
16382201-3	2005	The suppression was attenuated by LF given to mice in drinking water as determined by the number of antibody-forming cells (AFC) in the spleen and the magnitude of delayed type of hypersensitivity (DTH).	Water	63-68	lactotransferrin	Mus musculus	34-36
28478670-7	2017	We find that MP2/aug-cc-pVDZ and several DFT methods (such as LC-omegaPBE-D3 and omegaB97XD) with the aug-cc-pVTZ basis set can provide satisfactory descriptions for these water clusters.	Water	172-177	tryptase pseudogene 1	Homo sapiens	13-16
28626609-9	2017	Notably, only the E. coli from water samples possessed ESBL phenotype and carried antibiotic resistance genes, blaTEM and blaCMY-2.	Water	31-36	AmpC	Escherichia coli	122-130
16229482-2	2005	Although it is generally held that the active sites of acyl-CoA dehydrogenases are desolvated when substrate binds, recent evidence has established that water has access to the active site in these binary complexes of glutaryl-CoA dehydrogenase.	Water	153-158	glutaryl-CoA dehydrogenase	Homo sapiens	218-244
16229482-6	2005	The involvement of water in catalysis by glutaryl-CoA dehydrogenase was previously unrecognized and is in conflict with a classically held intramolecular 1,3-prototropic shift for protonation of crotonyl-CoA dienolate.	Water	19-24	glutaryl-CoA dehydrogenase	Homo sapiens	41-67
29151605-0	2017	Sub-arcsecond imaging of the water emission in Arp 220.	Water	29-34	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	47-50
16196138-0	2005	Liquid chromatography-tandem mass spectrometry analysis of estrogenic compounds in coastal surface water of the Baltic Sea.	Water	99-104	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	119-122
16120822-1	2005	Water homeostasis in humans is regulated by vasopressin, which induces the translocation of homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells.	Water	0-5	aquaporin 2	Homo sapiens	107-118
16120822-1	2005	Water homeostasis in humans is regulated by vasopressin, which induces the translocation of homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells.	Water	0-5	aquaporin 2	Homo sapiens	120-124
29151605-3	2017	Methods: We use sub-arcsecond resolution observations to tackle the nature of the water emission in Arp 220.	Water	82-87	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	100-103
29151605-5	2017	Results: We detect 183 GHz H2O and 325 GHz water emission towards the two compact nuclei at the center of Arp 220, being brighter in Arp 220 West.	Water	27-30	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	106-109
29151605-5	2017	Results: We detect 183 GHz H2O and 325 GHz water emission towards the two compact nuclei at the center of Arp 220, being brighter in Arp 220 West.	Water	43-48	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	106-109
29151605-5	2017	Results: We detect 183 GHz H2O and 325 GHz water emission towards the two compact nuclei at the center of Arp 220, being brighter in Arp 220 West.	Water	43-48	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	133-136
16120822-1	2005	Water homeostasis in humans is regulated by vasopressin, which induces the translocation of homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells.	Water	126-131	aquaporin 2	Homo sapiens	107-118
29151605-8	2017	Conclusions: Our findings suggest that the most likely scenario to cause the observed water emission in Arp 220 is a large number of independent masers originating from numerous star-forming regions.	Water	86-91	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	104-107
16120822-1	2005	Water homeostasis in humans is regulated by vasopressin, which induces the translocation of homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells.	Water	126-131	aquaporin 2	Homo sapiens	120-124
16120822-5	2005	Expressed in oocytes, AQP2-R254L appeared to be a functional water channel but was impaired in its transport to the cell surface to the same degree as AQP2-S256A, which mimics nonphosphorylated AQP2.	Water	61-66	aquaporin 2	Homo sapiens	22-27
28673060-11	2017	s-UCP values less than or equal to 20 cm H2O had a sensitivity of 73.1% and a specificity of 93.0% for predicting SUI.	Water	41-44	uncoupling protein 1	Homo sapiens	2-5
16120822-5	2005	Expressed in oocytes, AQP2-R254L appeared to be a functional water channel but was impaired in its transport to the cell surface to the same degree as AQP2-S256A, which mimics nonphosphorylated AQP2.	Water	61-66	aquaporin 2	Homo sapiens	22-26
15845620-4	2005	In this study we used rat PRL and a PRLR morpholino-antisense oligonucleotide to elucidate the mechanism by which hypothalamic PRLR mediates the inhibition of restraint stress in water (RSW)-induced hypocalcemia and gastric erosion.	Water	179-184	prolactin receptor	Rattus norvegicus	127-131
27864634-1	2017	Reactions of aquacobalamin (H2O-Cbl(III)) and its one-electron reduced form (cob(II)alamin, Cbl(II)) with chlorite (ClO2-) and chlorine dioxide (ClO 2  ) were studied by conventional and stopped-flow UV-Vis spectroscopies and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS).	Water	28-31	Cbl proto-oncogene	Homo sapiens	32-35
15815585-0	2005	Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet.	Water	45-50	endothelin 1	Mus musculus	0-12
15815585-9	2005	Our current data suggest that astrocytic ET-1 has deleterious effects on water homeostasis, cerebral edema and BBB integrity, which contribute to more severe ischemic brain injury.	Water	73-78	endothelin 1	Mus musculus	41-45
16014423-7	2005	Mice given LF or LPO showed a significantly lower lung consolidation score on day 6 after infection compared with the control mice that were given water instead.	Water	147-152	lactotransferrin	Mus musculus	11-13
16154425-1	2005	Aquaporins (AQPs) that transport glycerol in addition to water are classified as aquaglyceroporins (AQP3, 7, 9).	Water	57-62	aquaporin 3 (Gill blood group)	Rattus norvegicus	100-104
16052513-2	2005	In the present study, we investigated the effects of a potent water-soluble antioxidant, salvianolic acid B (SalB; derived from the Chinese herb, Salvia miltiorrhiza), on the expression of PAI-1 in TNF-alpha-treated human umbilical vein endothelial cells (HUVECs).	Water	62-67	serpin family E member 1	Homo sapiens	189-194
27864634-1	2017	Reactions of aquacobalamin (H2O-Cbl(III)) and its one-electron reduced form (cob(II)alamin, Cbl(II)) with chlorite (ClO2-) and chlorine dioxide (ClO 2  ) were studied by conventional and stopped-flow UV-Vis spectroscopies and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS).	Water	28-31	metabolism of cobalamin associated B	Homo sapiens	17-20
28475969-0	2017	Investigation of substrate recognition for cytochrome P450 1A2 mediated by water molecules using docking and molecular dynamics simulations.	Water	75-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	43-62
16087126-3	2005	STUDY DESIGN: The susceptibility of peripheral blood mononuclear cells from 17 subjects with chronic HCV infection to Fas ligand induced cell death was assessed using a water soluble tetrazolium assay.	Water	169-174	Fas ligand	Homo sapiens	118-128
15855355-2	2005	administration of the hexapeptide Ac-RYYRWK-NH(2), a partial agonist of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor, produces a selective water diuresis without marked cardiovascular or behavioral effects.	Water	152-157	prepronociceptin	Rattus norvegicus	76-86
15855355-2	2005	administration of the hexapeptide Ac-RYYRWK-NH(2), a partial agonist of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor, produces a selective water diuresis without marked cardiovascular or behavioral effects.	Water	152-157	prepronociceptin	Rattus norvegicus	87-98
28475969-1	2017	The role of water molecules in the active site of cytochrome P450 1A2 (CYP1A2) was investigated using an explicit water model to simulate biological environments.	Water	12-17	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-69
28475969-1	2017	The role of water molecules in the active site of cytochrome P450 1A2 (CYP1A2) was investigated using an explicit water model to simulate biological environments.	Water	12-17	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-77
16121255-2	2005	Human kindreds with nephrogenic diabetes insipidus have been found to harbor mutations in the vasopressin receptor 2 (Avpr2) gene or the vasopressin-sensitive water channel aquaporin-2 (Aqp2) gene.	Water	159-164	aquaporin 2	Mus musculus	173-184
16121255-6	2005	Previous in vitro experiments using renal cell lines suggest recessive Aqp2 mutations result in improper trafficking of the mutant water pore.	Water	131-136	aquaporin 2	Mus musculus	71-75
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	120-125	solute carrier family 4 member 2	Homo sapiens	443-446
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	174-179	solute carrier family 4 member 2	Homo sapiens	443-446
28475969-1	2017	The role of water molecules in the active site of cytochrome P450 1A2 (CYP1A2) was investigated using an explicit water model to simulate biological environments.	Water	114-119	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-69
16379428-3	2005	RESULTS: The optimum technology of extraction HCN from Semen Armeniacae Amarum was as follows: crushing to pieces, adding 3 times amount of 37 degrees C water and soaking overnight, extracting and collecting 1.33 times amount of extract; the optimum extraction process wasas follows: extracting 2 times, each time adding 12 times amount of water and extracting 1 h. CONCLUSION: The preparation technological process can be used for mass production.	Water	153-158	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	46-49
28475969-1	2017	The role of water molecules in the active site of cytochrome P450 1A2 (CYP1A2) was investigated using an explicit water model to simulate biological environments.	Water	114-119	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-77
16379428-3	2005	RESULTS: The optimum technology of extraction HCN from Semen Armeniacae Amarum was as follows: crushing to pieces, adding 3 times amount of 37 degrees C water and soaking overnight, extracting and collecting 1.33 times amount of extract; the optimum extraction process wasas follows: extracting 2 times, each time adding 12 times amount of water and extracting 1 h. CONCLUSION: The preparation technological process can be used for mass production.	Water	340-345	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	46-49
28475969-6	2017	These results suggest that CYP1A2 requires water molecules in its active site for substrate recognition.	Water	43-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	27-33
28212986-6	2017	The extent of conformational destabilization and protein aggregation of mAb-4 induced by APs followed their calculated octanol-water partition coefficients.	Water	127-132	immunoglobulin kappa variable 4-62	Mus musculus	72-77
15834924-7	2005	In this pathway a water molecule is inserted in between molybdenum and the SCO2 group.	Water	18-23	synthesis of cytochrome C oxidase 2	Homo sapiens	75-79
16418917-2	2005	In determinations of water samples inorganic arsenate (As(III), As(V)), methylated metabolities (MMAA, DMAA) and other organic forms such as AsB, AsC, arsenosugars or arsenic containing lipids have the most importance.	Water	21-26	arylsulfatase B	Homo sapiens	141-144
28603419-0	2017	In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies.	Water	23-28	Rh associated glycoprotein	Homo sapiens	49-52
15952032-5	2005	They activate enterocytes via guanylate cyclase C (GC-C) and increase the cellular concentration of cGMP which leads to secretion of Cl-, HCO3- and water into the intestinal lumen and to inhibition of Na+ absorption.	Water	148-153	natriuretic peptide receptor 3	Homo sapiens	51-55
16132820-0	2005	Water-protein hydrogen exchange in the micro-crystalline protein crh as observed by solid state NMR spectroscopy.	Water	0-5	corticotropin releasing hormone	Homo sapiens	65-68
28603419-6	2017	Furthermore, comparative analysis of the water solubility of BSA-Rh2 NPs and standard Rh2 showed that the BSA nanocarrier enhanced the water solubility of Rh2.	Water	41-46	Rh associated glycoprotein	Homo sapiens	65-68
16178227-1	2005	Oxide ceramics are sensitive to slow crack growth because adsorption of water can take place at the crack tip, leading to a strong decrease of the surface energy in humid (or air) conditions.	Water	72-77	TOR signaling pathway regulator	Homo sapiens	106-109
28603419-6	2017	Furthermore, comparative analysis of the water solubility of BSA-Rh2 NPs and standard Rh2 showed that the BSA nanocarrier enhanced the water solubility of Rh2.	Water	135-140	Rh associated glycoprotein	Homo sapiens	65-68
28471183-7	2017	Furthermore, data indicated that the major degradation product of MoS2-PPEG was water-soluble Mo-based ion.	Water	80-85	mago homolog, exon junction complex core component	Mus musculus	66-70
16161443-2	2005	METHOD: Water-soluble protein(ST1) was extracted by distilled water method and salting-out method, while keratin(ST2) by deoxidization method.	Water	8-13	syndecan binding protein	Homo sapiens	30-33
16161443-2	2005	METHOD: Water-soluble protein(ST1) was extracted by distilled water method and salting-out method, while keratin(ST2) by deoxidization method.	Water	62-67	syndecan binding protein	Homo sapiens	30-33
16033885-6	2005	Short-term PS1 inactivation in young PS1 cKO;APP Tg mice rescued deficits in contextual fear conditioning and serial spatial reversal learning in a water maze, which were associated with APP Tg mice.	Water	148-153	presenilin 1	Mus musculus	11-14
30363326-2	2017	In parallel with the rapid partition from water phase to bottom sediment, 1 was degraded with the first-order half-lives of 2.0 (trans-1) and 7.3 days (cis-1) in the water-sediment system under dark conditions.	Water	166-171	cytokine inducible SH2 containing protein	Homo sapiens	152-157
15979170-9	2005	Two genes (CC8 and CC9) were induced by cold stress and 5 genes (CCII, CC3, CC4, CC5 and CC9) were down-regulated in response to water starvation.	Water	129-134	multicystatin	Zea mays	81-84
16012037-1	2005	CONCLUSIONS: Our results indicate that the electrogenic kidney Na(+)/HCO(3)(-) cotransporter (kNBC), KCl cotransporter (KCC1 and -4) and Ca(2+)-activated Cl(-) channel (CaCC1, -2, -3) mRNAs are expressed in normal nasal mucosa and nasal polyp, suggesting that altered expression of all CaCC mRNAs in nasal polyp may cause impaired electrolyte and water transport across the epithelial cells.	Water	347-352	solute carrier family 12 member 4	Homo sapiens	120-131
16191654-5	2005	The maximum surge coincided closely in time with tidal high water, producing very high water levels along the coasts of the southern North Sea.	Water	60-65	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	139-142
28336531-2	2017	Here, we describe a mechanism that accounts for the ability of the peptide hormone vasopressin to regulate water excretion via a phosphorylation-dependent modulation of the PDZ domain-ligand interaction involving the water channel protein aquaporin-2.	Water	107-112	aquaporin 2	Homo sapiens	239-250
15644488-1	2005	Vasopressin-stimulated insertion of the aquaporin 2 (AQP2) water channel into the plasma membrane of kidney collecting duct principal cells is a key event in the urinary concentrating mechanism.	Water	59-64	aquaporin 2	Rattus norvegicus	40-51
15644488-1	2005	Vasopressin-stimulated insertion of the aquaporin 2 (AQP2) water channel into the plasma membrane of kidney collecting duct principal cells is a key event in the urinary concentrating mechanism.	Water	59-64	aquaporin 2	Rattus norvegicus	53-57
16012037-1	2005	CONCLUSIONS: Our results indicate that the electrogenic kidney Na(+)/HCO(3)(-) cotransporter (kNBC), KCl cotransporter (KCC1 and -4) and Ca(2+)-activated Cl(-) channel (CaCC1, -2, -3) mRNAs are expressed in normal nasal mucosa and nasal polyp, suggesting that altered expression of all CaCC mRNAs in nasal polyp may cause impaired electrolyte and water transport across the epithelial cells.	Water	347-352	anoctamin 1	Homo sapiens	137-167
15701373-6	2005	Transcript levels for collagen type I (Col I), ALP, and osteopontin (OP) increased (p&lt;0.05) in the water-based silk scaffolds in comparison to the HFIP-derived materials.	Water	102-107	secreted phosphoprotein 1	Homo sapiens	56-67
15681398-1	2005	The amiloride-sensitive epithelial sodium channel (ENaC) constitutes a rate-limiting step for sodium (Na+) and water absorption across lung alveolar epithelium.	Water	111-116	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	51-55
28422217-14	2017	We show that the negative entropy associated with the binding of trimethoprim in WT DHFR is due to water organization at the binding interface.	Water	99-104	Dihydrofolate reductase	Escherichia coli	84-88
15951206-10	2005	Versican and hyaluronic acid, working as water holding molecules would be responsible for the hydration of the ligament at the end of pregnancy, allowing an increase in resiliency.	Water	41-46	versican	Mus musculus	0-8
15966863-6	2005	Mechanistic analysis of the altered skin phenotype in AQP3 deficiency suggested that the glycerol rather than the water transporting function of AQP3 is important in skin physiology.	Water	114-119	aquaporin 3 (Gill blood group)	Homo sapiens	54-58
28368059-5	2017	Therefore, BRI can act as an "OFF-ON" fluorescent probe switch in CH3CN/H2O (3 : 2 v/v) with a detection limit of 1 muM in solution, whereas RhB1 and RhB1-CD act as "ON-OFF" fluorescent probes in EtOH/H2O (1 : 1 v/v) and water, respectively, with a detection limit of 10 muM.	Water	72-75	integral membrane protein 2B	Homo sapiens	11-14
16049696-1	2005	Vasopressin-induced trafficking of aquaporin-2 (AQP2) water channels in kidney collecting duct cells is critical to regulate the urine concentration.	Water	54-59	aquaporin 2	Canis lupus familiaris	35-46
16049696-1	2005	Vasopressin-induced trafficking of aquaporin-2 (AQP2) water channels in kidney collecting duct cells is critical to regulate the urine concentration.	Water	54-59	aquaporin 2	Canis lupus familiaris	48-52
16852004-1	2005	We observed a very unusual kinetic pathway in a separating C(12)E(6)/PEG/H(2)O ternary mixture.	Water	73-78	progestagen associated endometrial protein	Homo sapiens	69-72
15858274-0	2005	Water molecules in the antibody-antigen interface of the structure of the Fab HyHEL-5-lysozyme complex at 1.7 A resolution: comparison with results from isothermal titration calorimetry.	Water	0-5	FA complementation group B	Homo sapiens	74-77
15858274-5	2005	The refined structure has yielded a detailed picture of the Fab-lysozyme interface, showing the high complementarity of the protein surfaces as well as several water molecules within the interface that complete the good fit.	Water	160-165	FA complementation group B	Homo sapiens	60-63
28368059-5	2017	Therefore, BRI can act as an "OFF-ON" fluorescent probe switch in CH3CN/H2O (3 : 2 v/v) with a detection limit of 1 muM in solution, whereas RhB1 and RhB1-CD act as "ON-OFF" fluorescent probes in EtOH/H2O (1 : 1 v/v) and water, respectively, with a detection limit of 10 muM.	Water	201-204	integral membrane protein 2B	Homo sapiens	11-14
28368059-5	2017	Therefore, BRI can act as an "OFF-ON" fluorescent probe switch in CH3CN/H2O (3 : 2 v/v) with a detection limit of 1 muM in solution, whereas RhB1 and RhB1-CD act as "ON-OFF" fluorescent probes in EtOH/H2O (1 : 1 v/v) and water, respectively, with a detection limit of 10 muM.	Water	221-226	integral membrane protein 2B	Homo sapiens	11-14
16152947-0	2005	Analysis of the chloroacetanilide herbicides in water using SPME with CAR/PDMS and GC/ECD.	Water	48-53	CXADR pseudogene 1	Homo sapiens	70-73
28117534-9	2017	This is due to an unprecedented rate of technology-driven gains closing the gap between actual and water-limited potential yields by 25 kg ha-1  yr-1 enabling relative yields to increase from 39% in 1990 to 55% in 2015.	Water	99-104	plasma membrane ATPase	Triticum aestivum	139-149
15647389-3	2005	AQP8-knockout mice lacked detectable AQP8 transcript and protein, and had reduced water permeability in plasma membranes from testes.	Water	82-87	aquaporin 8	Mus musculus	0-4
28559597-9	2017	Addition of 1% EA increased water-holding capacity (WHC) of the samples, while higher level of EA (2%) caused decrement in the same.	Water	28-33	ovalbumin	Meleagris gallopavo	15-17
15914904-3	2005	Its distilled water fraction (WEx) was found to stimulate tyrosinase activity in cultured mouse B16 melanoma cells and hair color pigmentation in C3H mice.	Water	14-19	tyrosinase	Mus musculus	58-68
15972638-2	2005	EAU-susceptible B10.RIII mice immunized with the retinal autoantigen interphotoreceptor retinoid binding protein in CFA and treated with anti-CD40L Ab (MR1) had reduced incidence and severity of disease.	Water	0-3	CD40 ligand	Mus musculus	142-147
15972638-2	2005	EAU-susceptible B10.RIII mice immunized with the retinal autoantigen interphotoreceptor retinoid binding protein in CFA and treated with anti-CD40L Ab (MR1) had reduced incidence and severity of disease.	Water	0-3	major histocompatibility complex, class I-related	Mus musculus	152-155
15972638-6	2005	MR1-treated mice developed severe EAU and strong cellular responses to interphotoreceptor retinoid binding protein, comparable to those of control mice.	Water	34-37	major histocompatibility complex, class I-related	Mus musculus	0-3
28447712-2	2017	Water channels, particularly aquaporin-2 (AQP2), are important proteins in water homeostasis in the body through the short-term and long-term regulation of water permeability.	Water	0-5	aquaporin 2	Mus musculus	29-40
15952772-9	2005	From H(2)O/(2)H(2)O exchange experiments, we concluded that the impact of Zn(2+) and Cd(2+) binding on the oxidation kinetics of ferrocytochrome c by H(2)O(2) is associated to the perturbation of a hydrogen-bonding network involving His 33 that is sensitive to the redox state of cytochrome c.	Water	5-10	cytochrome c, somatic	Equus caballus	134-146
15952772-9	2005	From H(2)O/(2)H(2)O exchange experiments, we concluded that the impact of Zn(2+) and Cd(2+) binding on the oxidation kinetics of ferrocytochrome c by H(2)O(2) is associated to the perturbation of a hydrogen-bonding network involving His 33 that is sensitive to the redox state of cytochrome c.	Water	14-19	cytochrome c, somatic	Equus caballus	134-146
15728717-12	2005	Inhibition of IL-18 also prevented an increase in intestinal tissue water content.	Water	68-73	interleukin 18	Rattus norvegicus	14-19
28447712-2	2017	Water channels, particularly aquaporin-2 (AQP2), are important proteins in water homeostasis in the body through the short-term and long-term regulation of water permeability.	Water	0-5	aquaporin 2	Mus musculus	42-46
28447712-2	2017	Water channels, particularly aquaporin-2 (AQP2), are important proteins in water homeostasis in the body through the short-term and long-term regulation of water permeability.	Water	75-80	aquaporin 2	Mus musculus	29-40
15840033-2	2005	Although the expressional alteration of the kidney-specific apical water channel, aquaporin 2 (AQP2), in the collecting duct has been demonstrated to be involved in the development of hyponatremia and the subsequent physiologic reaction that is resistant to arginine vasopressin (AVP; vasopressin escape) in SIADH, the complete pathogenesis of and the appropriate medical treatment for hyponatremia have yet to be elucidated.	Water	67-72	aquaporin 2	Rattus norvegicus	82-93
15884021-4	2005	In addition, the distance swum before reaching the escape platform was greater in NFL -/- mice than in controls during acquisition of place learning in the Morris water maze at the start of training.	Water	163-168	neurofilament, light polypeptide	Mus musculus	82-85
15840033-2	2005	Although the expressional alteration of the kidney-specific apical water channel, aquaporin 2 (AQP2), in the collecting duct has been demonstrated to be involved in the development of hyponatremia and the subsequent physiologic reaction that is resistant to arginine vasopressin (AVP; vasopressin escape) in SIADH, the complete pathogenesis of and the appropriate medical treatment for hyponatremia have yet to be elucidated.	Water	67-72	aquaporin 2	Rattus norvegicus	95-99
28447712-2	2017	Water channels, particularly aquaporin-2 (AQP2), are important proteins in water homeostasis in the body through the short-term and long-term regulation of water permeability.	Water	75-80	aquaporin 2	Mus musculus	42-46
15746100-1	2005	Aquaporin-7 (AQP7) is a water/glycerol transporting protein expressed in adipocyte plasma membranes.	Water	24-29	aquaporin 7	Mus musculus	0-11
28447712-2	2017	Water channels, particularly aquaporin-2 (AQP2), are important proteins in water homeostasis in the body through the short-term and long-term regulation of water permeability.	Water	156-161	aquaporin 2	Mus musculus	29-40
15746100-1	2005	Aquaporin-7 (AQP7) is a water/glycerol transporting protein expressed in adipocyte plasma membranes.	Water	24-29	aquaporin 7	Mus musculus	13-17
28447712-2	2017	Water channels, particularly aquaporin-2 (AQP2), are important proteins in water homeostasis in the body through the short-term and long-term regulation of water permeability.	Water	156-161	aquaporin 2	Mus musculus	42-46
28541940-0	2017	Efficient removal of Cd2+ ion from water by calcium alginate hydrogel filtration membrane.	Water	35-40	CD2 molecule	Homo sapiens	21-24
15840384-12	2005	These data are consistent with previous studies where chronic exposure to this chemical mixture in drinking water resulted in a less than additive carcinogenic response in Tsc2 mutant Long-Evans rats.	Water	108-113	TSC complex subunit 2	Rattus norvegicus	172-176
15882846-12	2005	The amount of water lost upon drying is consistent with the idea that the material is a monohydrate of beta-C(12)G(1).	Water	14-19	colony stimulating factor 2 receptor subunit beta	Homo sapiens	103-109
28881775-1	2017	UGT2B15 (uridine diphosphate-glucuronosyltransferase 2B15) catalyzes the conversion of lipophilic C19 steroid androgens such as dihydrotestosterone (DHT) into water-soluble metabolites that can be excreted.	Water	159-164	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	0-7
15718385-7	2005	Fos was elevated similarly in osmo- and volume-sensitive regions of the basal forebrain and hypothalamus in wild-type and OT -/- mice after water deprivation.	Water	140-145	FBJ osteosarcoma oncogene	Mus musculus	0-3
15723236-5	2005	In this study, we observed a mislocalization of Kir4.1 in various human brain tumors (low- and high-grade astrocytomas and oligodendrogliomas), suggesting that buffering capacity of glial cells may be compromised, leading to water influx (cytotoxic edema).	Water	225-230	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	48-54
28881775-1	2017	UGT2B15 (uridine diphosphate-glucuronosyltransferase 2B15) catalyzes the conversion of lipophilic C19 steroid androgens such as dihydrotestosterone (DHT) into water-soluble metabolites that can be excreted.	Water	159-164	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	9-57
28473751-4	2017	In the present study, we hypothesize that adropin, a new endogenous peptide hormone, was rapidly increased (serum and brain) concomitant with reduced water intake in early hypoxia.	Water	150-155	energy homeostasis associated	Rattus norvegicus	42-49
15536172-1	2005	The antidiuretic hormone arginine vasopressin increases the osmotic water permeability of the renal collecting ducts by inducing the shuttling of aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical plasma membrane of the principal cells.	Water	165-170	aquaporin 2	Homo sapiens	146-157
15536172-1	2005	The antidiuretic hormone arginine vasopressin increases the osmotic water permeability of the renal collecting ducts by inducing the shuttling of aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical plasma membrane of the principal cells.	Water	165-170	aquaporin 2	Homo sapiens	159-163
15792863-11	2005	Tryptophan buried in proteins, namely calcium parvalbumin from cod and aldolase from rabbit, showed temperature profiles of the fluorescence spectra that were largely independent of the solvent (glycerol/water or sugar glass) and temperature whereas the fluorescence and phosphorescence yields were dependent.	Water	204-209	parvalbumin alpha	Oryctolagus cuniculus	46-57
16037238-5	2005	Quantitative determinations of K2P in individual normal human lens or cataract lens water-soluble and water-insoluble protein digests revealed a significant enhancement of K2P in the early stage of brunescent cataract lens proteins (type I/II, 613 +/- 362 pmol/mg of water-insoluble sonicate supernatant (WISS) protein or 85 +/- 51 pmol/mg of water-soluble [WS] protein) when compared with aged normal human lens proteins (261 +/- 93 pmol/mg of WISS protein or 23 +/- 15 pmol/mg of WS protein).	Water	84-89	keratin 76	Homo sapiens	31-34
15857641-1	2005	Nanoscale zerovalent copper supported on a cation resin was successfully synthesized to enhance the removal of carbon tetrachloride (CCl(4)) from contaminated water.	Water	159-164	C-C motif chemokine ligand 4	Homo sapiens	133-139
28383588-6	2017	Our results also suggest that a similar mechanism accounts for the modification of myoglobin charge at the air/water interface.	Water	111-116	myoglobin	Homo sapiens	83-92
15910548-6	2005	Water-soluble Abeta is the native counterpart of the Abeta small aggregates (soluble oligomers) that show in vitro an early and high neuronal toxicity.	Water	0-5	amyloid beta (A4) precursor protein	Mus musculus	14-19
15910548-6	2005	Water-soluble Abeta is the native counterpart of the Abeta small aggregates (soluble oligomers) that show in vitro an early and high neuronal toxicity.	Water	0-5	amyloid beta (A4) precursor protein	Mus musculus	53-58
16019941-2	2005	The pulse radiolysis of ART in H(2)O/ethanol (EtOH) (1:1 v/v) solution was studied in the absence and presence of the so-called redox indicators N,N,N",N"-tetramethyl-p-phenylenediamine (TMPD), Fe(CN)6(4-), 1,1"-dimethyl-4,4"-bipyridinium dichloride (methyl viologen, MV(2+)) and Fe(CN)6(3-).	Water	31-36	artemin	Homo sapiens	24-27
28386615-2	2017	In this work, ultra-small-angle X-ray scattering (USAXS) was applied to investigate the formation of self-assembled zein structures in binary solvent systems of ethanol and water.	Water	173-178	zein	Zea mays	116-120
15898816-6	2005	Acid titration of ferric cyt c in 9 M urea down to pH 2 is accompanied by protonation of one of the axial ligands, water binding to the heme iron (pK(a) = 5.2), and a sudden protein collapse (pH &lt; 4).	Water	115-120	cytochrome c, somatic	Equus caballus	25-30
15763584-0	2005	Leptin effects on food and water intake in lines of chickens selected for high or low body weight.	Water	27-32	leptin	Gallus gallus	0-6
28424593-7	2017	In vivo, combined treatment with Prdx6-iPLA2 activity inhibitor MJ33 showed a greater diminution in neurologic deficits, cerebral infarction, brain water content and inflammatory molecules than Prdx6-siRNA treatment alone.	Water	148-153	phospholipase A2 group VI	Rattus norvegicus	39-44
16833487-3	2005	The EFP1 method is compared with second-order perturbation theory (MP2) and DFT results for n = 1, 2, and 3, and EFP1 results are also presented for four water molecules.	Water	154-159	thioredoxin domain containing 11	Homo sapiens	4-8
15917461-7	2005	Mice overproducing amyloid-beta (Abeta), particularly those with amyloid deposits, showed weaker memory for the platform location in the classic Morris water maze and learned new platform positions in the repeated-reversals task less quickly than their nontransgenic cagemates.	Water	152-157	amyloid beta (A4) precursor protein	Mus musculus	33-38
15823548-1	2005	Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis.	Water	24-29	aquaporin 2	Rattus norvegicus	51-55
27932501-10	2017	These findings show, for the first time, that SVCT-1 and SVCT-2 are differentially expressed along the intestinal tract and that this pattern of expression is, at least in part, mediated via transcriptional/epigenetic mechanisms.NEW &amp; NOTEWORTHY Our findings show, for the first time, that transporters of the water-soluble vitamin ascorbic acid (i.e., the vitamin C transporters SVCT-1 and SVCT-2) are differentially expressed along the length of the intestinal tract and that the pattern of expression is mediated, at least in part, by transcriptional and epigenetic mechanism(s) affecting both Slc23a1 and Slc23a2 genes.	Water	314-319	solute carrier family 23 member 1	Homo sapiens	46-52
15522986-8	2005	However, water deprivation for 24 h decreased urine volume from 58 +/- 9 to 28 +/- 4 microl x g body wt(-1) x 24 h(-1) in WT mice (P &lt; 0.05), whereas in THP -/- mice this decrease was less pronounced (57 +/- 4 to 41 +/- 5 microl x g body wt(-1) x 24 h(-1); P &lt; 0.05), revealing significant interstrain difference (P &lt; 0.05).	Water	9-14	uromodulin	Mus musculus	156-159
28451361-0	2017	Vapor-solid synthesis of monolithic single-crystalline CoP nanowire electrodes for efficient and robust water electrolysis.	Water	104-109	caspase recruitment domain family member 16	Homo sapiens	55-58
15713410-4	2005	The pyrazole ring forms hydrogen bonds to the backbone carbonyl of Gly97, the hydroxyl group of Thr184 and to a water molecule, which is present in all of the published HSP90 structures.	Water	112-117	heat shock protein 90 alpha family class A member 1	Homo sapiens	169-174
15823548-2	2005	Trafficking of AQP2 to the apical membrane is critical to the reabsorption of water in renal collecting ducts.	Water	78-83	aquaporin 2	Rattus norvegicus	15-19
16852094-5	2005	Quantum mechanical ab initio calculations of the hexa- and heptahydrated complexes extracted from MD configurations have revealed stable minima for both clusters with the water molecules arranged in T(h)() and C(2) symmetries in the hexa- and heptahydrated complexes, respectively, with a slight energetic preference for the heptahydrated one.	Water	171-176	hexosaminidase subunit alpha	Homo sapiens	49-53
15845093-8	2005	We then confirmed that c-Fos was induced in 60% of relaxin 3 neurons in the NI and the expression of relaxin 3 mRNA increased significantly in the NI after water-restraint stress.	Water	156-161	relaxin 3	Rattus norvegicus	101-110
16852094-5	2005	Quantum mechanical ab initio calculations of the hexa- and heptahydrated complexes extracted from MD configurations have revealed stable minima for both clusters with the water molecules arranged in T(h)() and C(2) symmetries in the hexa- and heptahydrated complexes, respectively, with a slight energetic preference for the heptahydrated one.	Water	171-176	hexosaminidase subunit alpha	Homo sapiens	233-237
28451361-4	2017	Herein, we report a novel vapor-solid synthesis of single-crystalline cobalt phosphide nanowires (CoP NWs) on a porous Co foam and demonstrate their use in overall water splitting.	Water	164-169	caspase recruitment domain family member 16	Homo sapiens	98-101
27566278-3	2017	These data were compared to a priori values developed in the context of a thermodynamic model for binary mixtures of glycerine and water and a previously determined water sorption isotherm for HSC.	Water	165-170	fucosyltransferase 1 (H blood group)	Homo sapiens	193-196
27942751-2	2017	In this study, we examined the effect of S1P1 agonist, ONO-W061, on murine Candida albicans water-soluble fraction (CAWS)-induced vasculitis.	Water	92-97	sphingosine-1-phosphate receptor 1	Mus musculus	41-45
15753079-1	2005	The epithelial Na(+) channel (ENaC) regulates epithelial salt and water reabsorption, processes that require significant expenditure of cellular energy.	Water	66-71	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	4-28
15753079-1	2005	The epithelial Na(+) channel (ENaC) regulates epithelial salt and water reabsorption, processes that require significant expenditure of cellular energy.	Water	66-71	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	30-34
15671070-1	2005	BACKGROUND: Aquaporin-2 (AQP-2) is an arginine vasopressin (AVP)-regulated water channel in kidney collecting duct cells.	Water	75-80	aquaporin 2	Canis lupus familiaris	12-23
15671070-1	2005	BACKGROUND: Aquaporin-2 (AQP-2) is an arginine vasopressin (AVP)-regulated water channel in kidney collecting duct cells.	Water	75-80	aquaporin 2	Canis lupus familiaris	25-30
27317656-4	2017	Endogenous low-density lipoprotein receptor-related protein-1 and hemopexin were increased in ipsilateral brain after intracerebral hemorrhage, accompanied by increased hemoglobin levels, brain water content, blood-brain barrier permeability and neurological deficits.	Water	194-199	hemopexin	Mus musculus	66-75
15707779-1	2005	In this study, we evaluate the biosafety and bioactivity (antioxidant potential) of a traditional water infusion (tea) of common sage (Salvia officinalis L.) in vivo in mice and rats by quantification of plasma transaminase activities and liver glutathione-S-transferase (GST) and glutathione reductase (GR) enzyme activities.	Water	98-103	hematopoietic prostaglandin D synthase	Rattus norvegicus	245-270
15707779-1	2005	In this study, we evaluate the biosafety and bioactivity (antioxidant potential) of a traditional water infusion (tea) of common sage (Salvia officinalis L.) in vivo in mice and rats by quantification of plasma transaminase activities and liver glutathione-S-transferase (GST) and glutathione reductase (GR) enzyme activities.	Water	98-103	hematopoietic prostaglandin D synthase	Rattus norvegicus	272-275
15707779-1	2005	In this study, we evaluate the biosafety and bioactivity (antioxidant potential) of a traditional water infusion (tea) of common sage (Salvia officinalis L.) in vivo in mice and rats by quantification of plasma transaminase activities and liver glutathione-S-transferase (GST) and glutathione reductase (GR) enzyme activities.	Water	98-103	glutathione-disulfide reductase	Rattus norvegicus	281-302
15707779-1	2005	In this study, we evaluate the biosafety and bioactivity (antioxidant potential) of a traditional water infusion (tea) of common sage (Salvia officinalis L.) in vivo in mice and rats by quantification of plasma transaminase activities and liver glutathione-S-transferase (GST) and glutathione reductase (GR) enzyme activities.	Water	98-103	glutathione-disulfide reductase	Rattus norvegicus	304-306
16833720-1	2005	The potential energy profiles for proton-transfer reactions of 2-hydroxypyridine and its complexes with water were determined by MP2, CASSCF and MR-CI calculations with the 6-31G** basis set.	Water	104-109	tryptase pseudogene 1	Homo sapiens	129-132
28304043-1	2017	The inhibition of water and glycerol permeation via human aquaglyceroporin-3 (AQP3) by gold(iii) complexes has been studied by stopped-flow spectroscopy and, for the first time, its mechanism has been described using molecular dynamics (MD), combined with density functional theory (DFT) and electrochemical studies.	Water	18-23	aquaporin 3 (Gill blood group)	Homo sapiens	58-76
15722055-8	2005	These results indicate that 5-HT1A receptor-mediated circuits located in the midline superior raphe system of the pigeon may play an important role in mechanisms controlling water intake, similar to that observed in mammals.	Water	174-179	5-hydroxytryptamine receptor 1A	Homo sapiens	28-43
28304043-1	2017	The inhibition of water and glycerol permeation via human aquaglyceroporin-3 (AQP3) by gold(iii) complexes has been studied by stopped-flow spectroscopy and, for the first time, its mechanism has been described using molecular dynamics (MD), combined with density functional theory (DFT) and electrochemical studies.	Water	18-23	aquaporin 3 (Gill blood group)	Homo sapiens	78-82
15494547-1	2005	In the renal collecting duct (CD), water reabsorption depends on the presence of aquaporin-2 (AQP2) in the apical membrane of principal cells.	Water	35-40	aquaporin 2	Mus musculus	81-92
15494547-1	2005	In the renal collecting duct (CD), water reabsorption depends on the presence of aquaporin-2 (AQP2) in the apical membrane of principal cells.	Water	35-40	aquaporin 2	Mus musculus	94-98
28304043-2	2017	The obtained MD results showed that the most effective gold-based inhibitor, anchored to Cys40 in AQP3, is able to induce shrinkage of pores preventing glycerol and water permeation.	Water	165-170	aquaporin 3 (Gill blood group)	Homo sapiens	98-102
28295117-2	2017	The Ecm inhibition and rotational enhancement observed for these reactions at Ecm &lt; 0.5 eV are generally consistent with those reported previously for H2O+ + H2(D2) reactions.	Water	154-157	multimerin 1	Homo sapiens	4-7
15365768-0	2005	Granulocyte colony-stimulating factor-induced capillary leak syndrome confirmed by extravascular lung water measurements.	Water	102-107	colony stimulating factor 3	Homo sapiens	0-37
15365768-1	2005	The study purpose was to report the first case of granulocyte colony-stimulating factor (G-CSF)-induced capillary leak syndrome (CLS) in which serial extravascular lung water (EVLW) measurements were performed and to compare this case with previously reported cases.	Water	169-174	colony stimulating factor 3	Homo sapiens	50-87
15365768-1	2005	The study purpose was to report the first case of granulocyte colony-stimulating factor (G-CSF)-induced capillary leak syndrome (CLS) in which serial extravascular lung water (EVLW) measurements were performed and to compare this case with previously reported cases.	Water	169-174	colony stimulating factor 3	Homo sapiens	89-94
28295117-2	2017	The Ecm inhibition and rotational enhancement observed for these reactions at Ecm &lt; 0.5 eV are generally consistent with those reported previously for H2O+ + H2(D2) reactions.	Water	154-157	multimerin 1	Homo sapiens	78-81
28295117-3	2017	However, in contrast to the vibrational inhibition observed for the latter reactions at low Ecm &lt; 0.5 eV, both the sigmaHT and sigmaDT for the H2O+ + HD reaction are found to be enhanced by (100) vibrational excitation, which is not predicted by the current state-of-the-art theoretical dynamics calculations.	Water	146-149	multimerin 1	Homo sapiens	92-95
28295117-4	2017	Furthermore, the (100) vibrational enhancement for the H2O+ + HD reaction is observed in the full Ecm range of 0.03-10.00 eV.	Water	55-58	multimerin 1	Homo sapiens	98-101
15231573-6	2005	Forced expression of GSTP1 by transfection of Raji cells significantly decreased the basal amount of H(2)O(2) and its levels after therapeutic concentration of As(2)O(3) treatment.	Water	101-106	glutathione S-transferase pi 1	Homo sapiens	21-26
28300240-1	2017	A novel supramolecular assembly was constructed by the noncovalent complexation of hexa-cata-hexabenzocoronene modified permethyl-beta-cyclodextrins with tetrasodium tetraphenylporphyrintetrasulfonate in water, exhibiting highly efficient excited energy transfer behaviors and a promising DNA photocleavage ability.	Water	204-209	hexosaminidase subunit alpha	Homo sapiens	83-87
15652761-10	2005	In experiments where mice were provided ethanol chronically in drinking water, where stress is minimal, higher levels of ALT were noted in animals in the ethanol group as compared with animals in the control group.	Water	72-77	glutamic pyruvic transaminase, soluble	Mus musculus	121-124
28274117-0	2017	Self-Assembly Nanostructures of Triglyceride-Water Interfaces Determine Functional Conformations of Candida antarctica Lipase B. Candida antarctica lipase B (CalB) acts as a lipase when adsorbed to an acylglyceride interface and as an esterase when exposed to an aqueous environment.	Water	45-50	PAN0_003d1715	Moesziomyces antarcticus	119-125
28274117-0	2017	Self-Assembly Nanostructures of Triglyceride-Water Interfaces Determine Functional Conformations of Candida antarctica Lipase B. Candida antarctica lipase B (CalB) acts as a lipase when adsorbed to an acylglyceride interface and as an esterase when exposed to an aqueous environment.	Water	45-50	PAN0_003d1715	Moesziomyces antarcticus	148-154
28507478-6	2017	Melatonin treatment (10 mg/kg, daily in drinking water for 6 months) in aged mice significantly attenuated the age-induced downregulation of SIRT1, FOXO1, MT1 and MT2 protein expression and attenuated the age-induced increase in p53, ac-p53, MDM2, and DKK1 protein and mRNA expression.	Water	49-54	sirtuin 1	Mus musculus	141-146
28507478-6	2017	Melatonin treatment (10 mg/kg, daily in drinking water for 6 months) in aged mice significantly attenuated the age-induced downregulation of SIRT1, FOXO1, MT1 and MT2 protein expression and attenuated the age-induced increase in p53, ac-p53, MDM2, and DKK1 protein and mRNA expression.	Water	49-54	forkhead box O1	Mus musculus	148-153
28233979-3	2017	Hierarchical CdS microstructures with different morphologies such as microspheres assembled of nanoplates, nanorods, nanoparticles, and nanobelts are synthesized using a simple hydrothermal method by tuning the volume ratio of solvents, i.e., water or ethylenediamine (en).	Water	243-248	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
28233979-5	2017	Four selected CdS microstructures are used as photocatalysts for the degradation of methylene blue and photoelectrochemical water splitting for hydrogen generation.	Water	124-129	CDP-diacylglycerol synthase 1	Homo sapiens	14-17
32263691-7	2017	Finally, bicyclononyne groups were grafted onto the star-pPR based fibers allowing the conjugation of a fluorescent dye by click chemistry in water without any copper catalyst proving the potential of the method for the biofunctionalization of PCL-based fibers.	Water	142-147	PPR1	Homo sapiens	57-60
28057529-10	2017	In two tests of hippocampus-dependent learning, the Morris water maze and extinction of contextual fear, mutation of one or both alleles of Alk was sufficient to improve performance to wild type or near wild type levels in NF1-/+ mice.	Water	59-64	anaplastic lymphoma kinase	Mus musculus	140-143
28256650-0	2017	Synthesis of new photosensitive H2BBQ2+[ZnCl4]2-/[(ZnCl)2(mu-BBH)] complexes, through selective oxidation of H2O to H2O2.	Water	109-112	gamma-butyrobetaine hydroxylase 1	Homo sapiens	61-64
28256650-2	2017	Under light illumination the H2BBQ2+[ZnCl4]2- + ZnCl2 is reduced quantitatively to [(ZnCl)2(mu-BBH)] (pH ~ 5) oxidizing H2O to H2O2 as is evident by trap experiments.	Water	120-123	gamma-butyrobetaine hydroxylase 1	Homo sapiens	95-98
28297654-5	2017	Our measurements show that mutation of two pore-lining tyrosine residues, Tyr-23 and Tyr-149 in sheep AQP0, to the corresponding residues in the high-permeability water channel AQP1 have additive effects and together increase the water permeability of AQP0 40-fold to a level comparable to that of AQP1.	Water	163-168	aquaporin-1	Ovis aries	177-181
28297654-5	2017	Our measurements show that mutation of two pore-lining tyrosine residues, Tyr-23 and Tyr-149 in sheep AQP0, to the corresponding residues in the high-permeability water channel AQP1 have additive effects and together increase the water permeability of AQP0 40-fold to a level comparable to that of AQP1.	Water	163-168	aquaporin-1	Ovis aries	298-302
28297654-5	2017	Our measurements show that mutation of two pore-lining tyrosine residues, Tyr-23 and Tyr-149 in sheep AQP0, to the corresponding residues in the high-permeability water channel AQP1 have additive effects and together increase the water permeability of AQP0 40-fold to a level comparable to that of AQP1.	Water	230-235	aquaporin-1	Ovis aries	177-181
28297654-5	2017	Our measurements show that mutation of two pore-lining tyrosine residues, Tyr-23 and Tyr-149 in sheep AQP0, to the corresponding residues in the high-permeability water channel AQP1 have additive effects and together increase the water permeability of AQP0 40-fold to a level comparable to that of AQP1.	Water	230-235	aquaporin-1	Ovis aries	298-302
28196624-0	2017	Corrigendum to "Diffusion of water-soluble sorptive drugs in HEMA/MAA hydrogels" [J.	Water	29-34	MAA	Homo sapiens	66-69
27449362-0	2017	Enzymatic Activity of Glutathione S-Transferase and Dental Fluorosis Among Children Receiving Two Different Levels of Naturally Fluoridated Water.	Water	140-145	glutathione S-transferase kappa 1	Homo sapiens	22-47
27449362-1	2017	This study was conducted to measure the activity of the enzyme glutathione S-transferase (GST) in saliva and to compare the activity of this enzyme in children with and without dental fluorosis in communities with different concentrations of naturally fluoridated water.	Water	264-269	glutathione S-transferase kappa 1	Homo sapiens	63-88
27449362-1	2017	This study was conducted to measure the activity of the enzyme glutathione S-transferase (GST) in saliva and to compare the activity of this enzyme in children with and without dental fluorosis in communities with different concentrations of naturally fluoridated water.	Water	264-269	glutathione S-transferase kappa 1	Homo sapiens	90-93
28028733-2	2017	The samples were obtained by phase exclusion of linear ds DNA molecules from water-salt solutions of poly(ethylene glycol)-PEG-with concentrations ranging from 120 mg ml-1 to 300 mg ml-1.	Water	77-82	progestagen associated endometrial protein	Homo sapiens	123-126
28253085-0	2017	Water pipe (Shisha, Hookah, Arghile) Smoking and Secondhand Tobacco Smoke Effects on CYP1A2 and CYP2A6 Phenotypes as Measured by Caffeine Urine Test.	Water	0-5	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	85-91
28253085-8	2017	Nor was there a significant association between the extent of water pipe or secondhand smoke exposure and the CYP1A2 and CYP2A6 activities (p &gt; 0.05).	Water	62-67	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	110-116
28218316-0	2017	Theoretical study of HCN-water interaction: five dimensional potential energy surfaces.	Water	25-30	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	21-24
28218316-1	2017	A new five-dimensional potential energy surface is calculated at the coupled-cluster CCSD(T) level of theory for the HCN-water system, treating both monomers as rigid rotors.	Water	121-126	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	117-120
27852737-7	2017	Water-restricted, wild-type mice showed an increase in vasopressin and aldose reductase mRNA, sorbitol, fructose and uric acid in the supraoptic nucleus.	Water	0-5	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	71-87
15632412-1	2005	In vitro studies suggest that endothelin-1 (ET-1) inhibits vasopressin (AVP)-stimulated water permeability in the collecting duct (CD).	Water	88-93	endothelin 1	Mus musculus	30-42
15632412-1	2005	In vitro studies suggest that endothelin-1 (ET-1) inhibits vasopressin (AVP)-stimulated water permeability in the collecting duct (CD).	Water	88-93	endothelin 1	Mus musculus	44-48
27774687-7	2017	Compared to previous lower resolution structures, the enhanced resolution provides: (1) a detailed view of the active site of ZMPSTE24, including water coordinating the catalytic zinc; (2) enhanced visualization of fenestrations providing access from the exterior to the interior cavity of the protein; (3) a view of the C-terminus extending away from the main body of the protein; (4) localization of ordered lipid and detergent molecules at internal and external surfaces and also projecting through fenestrations; (5) identification of water molecules associated with the surface of the internal cavity.	Water	146-151	zinc metallopeptidase STE24	Homo sapiens	126-134
15863908-0	2005	AIP1, a water-soluble fraction from Artemisia iwayomogi, suppresses thymocyte apoptosis in vitro and down-regulates the expression of Fas gene.	Water	8-13	membrane associated guanylate kinase, WW and PDZ domain containing 2	Mus musculus	0-4
27774687-7	2017	Compared to previous lower resolution structures, the enhanced resolution provides: (1) a detailed view of the active site of ZMPSTE24, including water coordinating the catalytic zinc; (2) enhanced visualization of fenestrations providing access from the exterior to the interior cavity of the protein; (3) a view of the C-terminus extending away from the main body of the protein; (4) localization of ordered lipid and detergent molecules at internal and external surfaces and also projecting through fenestrations; (5) identification of water molecules associated with the surface of the internal cavity.	Water	539-544	zinc metallopeptidase STE24	Homo sapiens	126-134
15863908-1	2005	The AIP1 fraction, a small water-soluble fraction purified from Artemisia iwayomogi, was shown to increase antibody production and suppress transplanted tumor cell growth in mice.	Water	27-32	membrane associated guanylate kinase, WW and PDZ domain containing 2	Mus musculus	4-8
27465753-7	2017	Water-fed mice given EGF had decreased 7-day mortality compared with water-fed mice (18% vs. 55%).	Water	0-5	epidermal growth factor	Mus musculus	21-24
27465753-9	2017	Notably, while systemic EGF improved absolute survival to a similar degree in both water-fed and alcohol-fed mice, mortality was significantly higher in alcohol+EGF mice compared with water+EGF mice.	Water	83-88	epidermal growth factor	Mus musculus	24-27
27465753-16	2017	However, the efficacy of EGF in sepsis is blunted in the setting of chronic alcohol ingestion, as intestinal integrity and mortality in alcohol-fed mice given EGF improves animals to levels seen in water-fed mice given vehicle but does not approach levels seen in water-fed mice given EGF.	Water	264-269	epidermal growth factor	Mus musculus	25-28
15590761-2	2005	However, the roles of uroguanylin in nephrotic syndrome, which is associated with sodium and water retention, have not been determined.	Water	93-98	guanylate cyclase activator 2B	Rattus norvegicus	22-33
27845800-2	2017	Cyclic voltammograms (0.1 M borate buffer at pH = 8.4) of the resulting UiO67-[RuOH2]@FTO show a reversible wave associated with the RuIII/II couple in the anodic scan, followed by a large current response that arises from electrocatalytic water oxidation beyond 1.1 V vs. Ag/AgCl.	Water	240-245	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	86-89
15683432-9	2005	The gastric content of MPO, TNF-alpha and IL-1beta were all increased after water-immersion stress and reduced to near normal levels by ATL-146e.	Water	76-81	myeloperoxidase	Rattus norvegicus	23-26
27940358-5	2017	Comparative NMR analysis of the peptides spatial structures in water and membrane-mimicking environment showed that Ar-1[V8R] in contrast to arenicin has significantly lower dimerization propensity.	Water	63-68	transcription factor 20	Homo sapiens	116-124
15666408-8	2005	The water pool absolute size (PDf) showed a weaker correlation with T(1,obs) (positive, r2 = 0.53; P &lt; 0.0001).	Water	4-9	peptide deformylase, mitochondrial	Homo sapiens	30-33
27522013-2	2017	In the present work, a portable, ultrasensitive SERS sensor is proposed and utilized for detecting trace mercury ions in water.	Water	121-126	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	48-52
15705184-10	2005	CONCLUSION: Our results reveal that the water transport in urinary concentration involves the downregulation of AQP2 and AQP3 expression in STZ mice.	Water	40-45	aquaporin 2	Mus musculus	112-116
15787753-0	2005	Quantitative risk assessment of FMD virus transmission via water.	Water	59-64	FMD	Bos taurus	32-35
15787753-5	2005	The objective of the present study was to assess the probability of infecting dairy cows that were drinking FMD virus contaminated surface water due to illegal discharges of contaminated milk.	Water	139-144	FMD	Bos taurus	108-111
27522013-6	2017	Therefore, by monitoring the decay of SERS signal of the dye, mercury ions in water can be detected qualitatively and quantitatively.	Water	78-83	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	38-42
15787753-7	2005	In the case of 1.6 x 10(2) FMD virus per milliliter in milk and discharge of treated sewage in surface water, the probability of infecting a herd of cows was estimated to be 3.3 x 10(-7) to 8.5 x 10(-5), dependent on dilution in the receiving surface water.	Water	251-256	FMD	Bos taurus	27-30
15787753-13	2005	This risk assessment clearly demonstrated the potential significance of FMD virus transmission via water, and the results will be useful on an international scale, and could also serve as a basis for other FMD risk-assessment models.	Water	99-104	FMD	Bos taurus	72-75
27522013-9	2017	The SERS sensor has been further executed to analyze the trace mercury ions in tap water and lake water respectively, and good recovery rates are obtained for sensing both kinds of water.	Water	83-88	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	4-8
27522013-9	2017	The SERS sensor has been further executed to analyze the trace mercury ions in tap water and lake water respectively, and good recovery rates are obtained for sensing both kinds of water.	Water	98-103	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	4-8
15724202-1	2005	The electron transfer reaction of wild-type myoglobin at an electrode was significantly facilitated in a D2O buffer as compared with that in an H2O buffer, with k(0)"(H2O)/k(0)"(D2O)= 0.13, while a minimal deuterium kinetic isotope effect on the myoglobin with modification at distal histidine (His-64) was observed.	Water	144-147	myoglobin	Homo sapiens	44-53
27522013-9	2017	The SERS sensor has been further executed to analyze the trace mercury ions in tap water and lake water respectively, and good recovery rates are obtained for sensing both kinds of water.	Water	98-103	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	4-8
15724202-1	2005	The electron transfer reaction of wild-type myoglobin at an electrode was significantly facilitated in a D2O buffer as compared with that in an H2O buffer, with k(0)"(H2O)/k(0)"(D2O)= 0.13, while a minimal deuterium kinetic isotope effect on the myoglobin with modification at distal histidine (His-64) was observed.	Water	167-170	myoglobin	Homo sapiens	44-53
15724202-1	2005	The electron transfer reaction of wild-type myoglobin at an electrode was significantly facilitated in a D2O buffer as compared with that in an H2O buffer, with k(0)"(H2O)/k(0)"(D2O)= 0.13, while a minimal deuterium kinetic isotope effect on the myoglobin with modification at distal histidine (His-64) was observed.	Water	167-170	myoglobin	Homo sapiens	246-255
27825648-9	2017	The predicted ECe was consistent with previous studies and revealed the distribution of ECe and helped to infer a freshwater intrusion from a water storage reservoir at depth and as a function of its proximity to near-surface prior stream channels and buried paleochannels.	Water	119-124	endothelin converting enzyme 1	Homo sapiens	14-17
16463893-1	2005	OBJECTIVES: Ifenprodil, a NMDA receptor polyamine site antagonist, reduces experimental cardiac arrest (CA)-elicited brain edema, which is associated with an up-regulation of aquaporin 4 (AQP4), a brain water-selective channel.	Water	203-208	aquaporin 4	Rattus norvegicus	188-192
27874124-2	2017	The novel alpha-Fe2O3/TiO2 hierarchical nanostructures, synthesized on FTO through a multi-step hydrothermal process, exhibit enhanced performances in photo-electrochemical water splitting and in the photocatalytic degradation of an organic dye, with respect to pure TiO2 nanotubes.	Water	173-178	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	71-74
16140463-2	2005	The diminished AVP-dependent osmotic water permeability of the collecting duct is the result of decreased AVP binding and adenylate cyclase activation, and low expression of aquaporin-2 (AQP2) mRNA and low levels of AQP2 protein.	Water	37-42	aquaporin 2	Homo sapiens	174-185
16140463-2	2005	The diminished AVP-dependent osmotic water permeability of the collecting duct is the result of decreased AVP binding and adenylate cyclase activation, and low expression of aquaporin-2 (AQP2) mRNA and low levels of AQP2 protein.	Water	37-42	aquaporin 2	Homo sapiens	187-191
16140463-2	2005	The diminished AVP-dependent osmotic water permeability of the collecting duct is the result of decreased AVP binding and adenylate cyclase activation, and low expression of aquaporin-2 (AQP2) mRNA and low levels of AQP2 protein.	Water	37-42	aquaporin 2	Homo sapiens	216-220
28005365-6	2017	Dendritic PEGylated TAM radicals, TNP1 and TNP2, have higher water solubility and lower susceptibility for self-aggregation than their linear analogues TPP1 and TPP2.	Water	61-66	transition protein 1	Mus musculus	34-38
15694703-9	2005	In CCl(4)-toxic fatty liver the strong increase of tissue water is substantially masked by the parallel increase of tissue dry solids due to fat accumulation.	Water	58-63	C-C motif chemokine ligand 4	Homo sapiens	3-9
28258571-1	2017	Several aquaporin (AQP )-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 -6 in the collecting duct; AQP7 in the proximal tubule; AQP8 in the proximal tubule and collecting duct; and AQP11 in the endoplasmic reticulum of proximal tubule cells.	Water	30-35	aquaporin 2	Mus musculus	146-150
16399355-7	2005	While ARSA, ARSB, and PAS are water-soluble enzymes, ES has a hydrophobic domain and is presumed to be bound to the endoplasmic reticulum membrane.	Water	30-35	arylsulfatase B	Homo sapiens	12-16
28258571-1	2017	Several aquaporin (AQP )-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 -6 in the collecting duct; AQP7 in the proximal tubule; AQP8 in the proximal tubule and collecting duct; and AQP11 in the endoplasmic reticulum of proximal tubule cells.	Water	30-35	aquaporin 7	Mus musculus	178-182
15692221-1	2005	BACKGROUND/AIMS: Water diuresis usually increases medullary oxygenation as a result of increased medullary synthesis of prostaglandins, but it is not clear whether this involves activation of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2).	Water	17-22	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	210-215
28258571-1	2017	Several aquaporin (AQP )-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 -6 in the collecting duct; AQP7 in the proximal tubule; AQP8 in the proximal tubule and collecting duct; and AQP11 in the endoplasmic reticulum of proximal tubule cells.	Water	30-35	aquaporin 8	Mus musculus	207-211
28269742-1	2017	BACKGROUND: In our earlier work, tobermorite containing calcium phosphate (CP) clusters (CP-Tob) was hydrothermally prepared in the CaO-SiO2-P2O5-H2O system for biomedical applications.	Water	146-149	transducer of ERBB2, 1	Homo sapiens	92-95
16908998-4	2005	In the Morris water maze task, PS1 KI mice at 3 months of age exhibit reduced quadrant occupancy and platform crossing in the probe trial after 6 days of training, though their performance was normal in the probe trial after 12 days of training.	Water	14-19	presenilin 1	Mus musculus	31-34
28019004-0	2017	Erratum to: Heavy metals relationship with water and size-fractionated sediments in rivers using canonical correlation analysis (CCA) case study, rivers of south western Caspian Sea.	Water	43-48	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	178-181
16285018-3	2005	These adducts are reactive towards nucleophiles and react with deoxyguanosine (dGMP) to form the ternary trans-[Pt(dGMP)(S-Met1-Ub) (Am)(pip-pip)] complex which is stable in water and even in the presence of excess glutathione (GSH).	Water	174-179	granzyme M	Homo sapiens	123-127
16156171-6	2005	Three- to six-year-old children benefitting from optimal fluoride supply through water or milk excreted approximately 0.35 to 0.40 mgF/24 h; this range seems to correspond to an optimal usage of fluorides.	Water	81-86	signal transducer and activator of transcription 5A	Homo sapiens	131-134
27830413-6	2017	A regression model of form ln(D) = 0.707ln(c 1p ) - 2.7391 with an R 2  = 0.9744 was obtained to relate the polymer-water partition coefficients (D) and concentration of hydrophobic organic compounds in passive sampler (c 1p ).	Water	116-121	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	43-47
15634052-1	2004	Six cyclic stationary points on the water trimer potential energy surface have been fully optimized at the MP2 level with the aug-cc-pVQZ basis set.	Water	36-41	tryptase pseudogene 1	Homo sapiens	107-110
27830413-6	2017	A regression model of form ln(D) = 0.707ln(c 1p ) - 2.7391 with an R 2  = 0.9744 was obtained to relate the polymer-water partition coefficients (D) and concentration of hydrophobic organic compounds in passive sampler (c 1p ).	Water	116-121	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	220-224
27830413-7	2017	It was also found that polymer-water partition coefficients are related to the concentration of hydrophobic organic compounds in water (c 1W ) as ln(D) = 2.412ln(c 1p ) - 9.348.	Water	31-36	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	162-166
15568844-3	2004	Here we report cross-linked films of myoglobin (Mb) and poly(L-lysine) (PLL) chemically attached to oxidized carbon cloth cathodes that in microemulsions feature the protein in a water-rich film environment with reactant in an oil-rich environment.	Water	179-184	myoglobin	Homo sapiens	37-46
27830413-7	2017	It was also found that polymer-water partition coefficients are related to the concentration of hydrophobic organic compounds in water (c 1W ) as ln(D) = 2.412ln(c 1p ) - 9.348.	Water	129-134	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	162-166
27830413-8	2017	Based on the results, the tie lines of concentration for hydrophobic organic compounds in passive sampler (c 1p ) and concentration of hydrophobic organic compounds in water (c 1W ) are in the form of ln(c 1W ) = 0.293ln(c 1p ) + 2.734.	Water	168-173	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	107-111
27830413-8	2017	Based on the results, the tie lines of concentration for hydrophobic organic compounds in passive sampler (c 1p ) and concentration of hydrophobic organic compounds in water (c 1W ) are in the form of ln(c 1W ) = 0.293ln(c 1p ) + 2.734.	Water	168-173	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	221-225
15347643-1	2004	We have previously demonstrated that vasopressin increases the water permeability of the inner medullary collecting duct (IMCD) by inducing trafficking of aquaporin-2 to the apical plasma membrane and that this response is dependent on intracellular calcium mobilization and calmodulin activation.	Water	63-68	aquaporin 2	Rattus norvegicus	155-166
28607573-4	2017	Our data also indicated differentially expressed genes (DEGs) related to water metabolism involved secretion, ion transport, water homeostasis, regulation of body fluid levels, and water channel activity; the expression of AQP1, AQP3, AQP4, AQP5, AQP6, and AQP8 was improved; calcium, cAMP, MAPK, PPAR, AMPK, and PI3K-Akt signaling pathway may be related to water metabolism.	Water	73-78	aquaporin 4	Rattus norvegicus	235-239
15557733-0	2004	Molecular mechanisms and drug development in aquaporin water channel diseases: water channel aquaporin-2 of kidney collecting duct cells.	Water	55-60	aquaporin 2	Canis lupus familiaris	93-104
15557733-1	2004	Aquaporin-2 (AQP2) is one of the membrane water channel proteins expressed in principal cells of the kidney collecting ducts.	Water	42-47	aquaporin 2	Canis lupus familiaris	0-11
29446594-1	2017	The solubility in the SAS - Vilagin - water systems has been investigated at 25  S for the purpose of the delivery of liquid disinfectants for various surfaces.	Water	38-43	tetraspanin 31	Homo sapiens	22-25
15557733-1	2004	Aquaporin-2 (AQP2) is one of the membrane water channel proteins expressed in principal cells of the kidney collecting ducts.	Water	42-47	aquaporin 2	Canis lupus familiaris	13-17
15557733-4	2004	This translocation enables the transepithelial reabsorption of water from the lumen to the interstitium via AQP2 at the apical membrane and AQP3/AQP4 at the basolateral membrane.	Water	63-68	aquaporin 2	Canis lupus familiaris	108-112
29446594-2	2017	There are established SAS as effective homogenisers for the stratified system "Vilagin - water", not effecting on the bactericidal activity of Vilagin.	Water	89-94	tetraspanin 31	Homo sapiens	22-25
15316021-6	2004	Quantitative determinations of K2P in individual normal human lens or cataract lens water-soluble and water-insoluble protein digests were made using a high-performance liquid chromatograph equipped with a diode array detector.	Water	84-89	keratin 76	Homo sapiens	31-34
27911305-6	2017	Using a Morris water maze test, we found that 9- and 12-month-old APP/PS1 mice showed memory deficit, compared to wild type mice.	Water	15-20	presenilin 1	Mus musculus	70-73
15316021-7	2004	These measurements revealed a significant enhancement of K2P in cataract lens proteins (613 +/- 362 pmol/mg of water-insoluble sonicate supernatant (WISS) protein or 85 +/- 51 pmol/mg of WS protein) when compared with aged normal human lens proteins (261 +/- 93 pmol/mg of WISS protein or 23 +/- 15 pmol/mg of water-soluble (WS) protein).	Water	111-116	keratin 76	Homo sapiens	57-60
15316021-7	2004	These measurements revealed a significant enhancement of K2P in cataract lens proteins (613 +/- 362 pmol/mg of water-insoluble sonicate supernatant (WISS) protein or 85 +/- 51 pmol/mg of WS protein) when compared with aged normal human lens proteins (261 +/- 93 pmol/mg of WISS protein or 23 +/- 15 pmol/mg of water-soluble (WS) protein).	Water	310-315	keratin 76	Homo sapiens	57-60
15926595-5	2005	Incorporating water affinity coefficients calculated from the developed relationship into the PDM model, isotherm predictions resulted that agreed well with experimental data for three adsorbents and two adsorbates [tetrachloroethene (PCE), cis-1,2-dichloroethene (DCE)] that were not used to calibrate the model.	Water	14-19	suppressor of cytokine signaling 1	Homo sapiens	241-246
16833656-2	2005	Binding energies and structures of the CO2-H2O and water-(CO2)2 complexes have been determined at the second-order level of the Moller-Plesset perturbation theory (MP2) using Dunning"s basis sets.	Water	43-46	tryptase pseudogene 1	Homo sapiens	164-167
16833656-2	2005	Binding energies and structures of the CO2-H2O and water-(CO2)2 complexes have been determined at the second-order level of the Moller-Plesset perturbation theory (MP2) using Dunning"s basis sets.	Water	51-56	tryptase pseudogene 1	Homo sapiens	164-167
27896810-7	2017	Adenosine release following treatments that cause astrocyte swelling is independent of calcium channels, but dependent on aquaporin 4, an astrocyte-specific water channel subtype.	Water	157-162	aquaporin 4	Rattus norvegicus	122-133
15811676-0	2005	Laboratory batch experiments of the combined effects of ultrasound and air stripping in removing CCl4 and 1,1,1-TCA from water.	Water	121-126	C-C motif chemokine ligand 4	Homo sapiens	97-101
15536172-1	2005	The antidiuretic hormone arginine vasopressin increases the osmotic water permeability of the renal collecting ducts by inducing the shuttling of aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical plasma membrane of the principal cells.	Water	68-73	aquaporin 2	Homo sapiens	146-157
15536172-1	2005	The antidiuretic hormone arginine vasopressin increases the osmotic water permeability of the renal collecting ducts by inducing the shuttling of aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical plasma membrane of the principal cells.	Water	68-73	aquaporin 2	Homo sapiens	159-163
15172884-1	2004	Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel.	Water	156-161	aquaporin 2	Rattus norvegicus	137-148
15172884-1	2004	Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel.	Water	156-161	aquaporin 2	Rattus norvegicus	150-154
15381403-8	2004	The reaction is initiated by the conjugate addition of water to the C-2, C-3 double bond and is followed by the loss of HCl.	Water	55-60	complement C2	Homo sapiens	68-76
27842175-12	2017	Furthermore, significant age-by-biomarker interactions were observed between myelin water fraction and phosphorylated tau 181/beta-amyloid 42, suggesting that phosphorylated tau 181/beta-amyloid 42 levels modulate age-related changes in myelin water fraction.	Water	84-89	microtubule associated protein tau	Homo sapiens	174-177
15551866-3	2004	Whether aquaporin-6 functions also as a water channel cannot yet be determined with confidence.	Water	40-45	aquaporin 6	Homo sapiens	8-19
27842175-12	2017	Furthermore, significant age-by-biomarker interactions were observed between myelin water fraction and phosphorylated tau 181/beta-amyloid 42, suggesting that phosphorylated tau 181/beta-amyloid 42 levels modulate age-related changes in myelin water fraction.	Water	244-249	microtubule associated protein tau	Homo sapiens	118-121
15973488-1	2005	Hydroquinone-alpha-glucoside was synthesised from hydroquinone and maltose as glucosyl donor by transglucosylation in a water system with alpha-glucosidase from baker"s yeast.	Water	120-125	sucrase-isomaltase	Homo sapiens	138-155
27842175-12	2017	Furthermore, significant age-by-biomarker interactions were observed between myelin water fraction and phosphorylated tau 181/beta-amyloid 42, suggesting that phosphorylated tau 181/beta-amyloid 42 levels modulate age-related changes in myelin water fraction.	Water	244-249	microtubule associated protein tau	Homo sapiens	174-177
30393725-3	2017	Compared to the velocities of these micromotors in pure water, 1.7, 1.5, and 1.4 times accelerated motions were observed for them in aqueous solutions of methyl blue (10-5 g L-1), cresol red (10-4 g L-1), and methyl orange (10-4 g L-1), respectively.	Water	56-61	l(1)L1	Drosophila melanogaster	174-177
15802850-0	2005	Design and synthesis of a novel water-soluble NMDA receptor antagonist with a 1,4,7,10-tetraazacyclododecane group.	Water	32-37	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	46-59
15802850-2	2005	Two types of water-soluble NMDA receptor antagonist, ACCn (1) and TGCn (2), with a 1,4,7,10-tetraazacyclododecane cyclic polyamine group, were synthesized and the effects of both compounds on NMDA receptors were studied using voltage-clamp recordings of recombinant NMDA receptors expressed in Xenopus oocytes.	Water	13-18	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	27-40
15349957-8	2004	However, DSPE-PEG 5000 micelles showed greater improvement in solubilization of the water-insoluble drug with an increase in PC content.	Water	84-89	progestagen associated endometrial protein	Homo sapiens	14-17
15458431-0	2004	Urinary excretion of aquaporin-2 water channel exaggerated dependent upon vasopressin in congestive heart failure.	Water	33-38	aquaporin 2	Homo sapiens	21-32
15458431-2	2004	The present study was undertaken to determine whether urinary excretion of aquaporin-2 (AQP-2) water channel is exaggerated in patients with congestive heart failure dependent upon arginine vasopressin (AVP).	Water	95-100	aquaporin 2	Homo sapiens	75-86
32269399-2	2017	However, human transformations of Earth"s surface have impacted water exchange between land, atmosphere, and ocean, ultimately affecting global sea level variations.	Water	64-69	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	144-147
15458431-2	2004	The present study was undertaken to determine whether urinary excretion of aquaporin-2 (AQP-2) water channel is exaggerated in patients with congestive heart failure dependent upon arginine vasopressin (AVP).	Water	95-100	aquaporin 2	Homo sapiens	88-93
15895592-0	2005	Distributions of beta+ decayed nuclei generated in the CH2 and H2O targets by the target nuclear fragment reaction using therapeutic MONO and SOBP proton beam.	Water	63-66	sine oculis binding protein homolog	Homo sapiens	142-146
16851648-0	2005	Influence of the water molecule on cation-pi interaction: ab initio second order Moller-Plesset perturbation theory (MP2) calculations.	Water	17-22	tryptase pseudogene 1	Homo sapiens	117-120
32269399-3	2017	Impoundment of water in reservoirs and artificial lakes has reduced the outflow of water to the sea, while river runoff has increased due to groundwater mining, wetland and endorheic lake storage losses, and deforestation.	Water	15-20	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	96-99
16851648-1	2005	The influence of introducing water molecules into a cation-pi complex on the interaction between the cation and the pi system was investigated using the MP2/6-311++G method to explore how a cation-pi complex changes in terms of both its geometry and its binding strength during the hydration.	Water	29-34	tryptase pseudogene 1	Homo sapiens	153-156
15248066-7	2004	Our results suggest that AQP3 is expressed not only in large airways, but also in bronchioles, and is related to water movement in pulmonary oedema.	Water	113-118	aquaporin 3 (Gill blood group)	Rattus norvegicus	25-29
32269399-3	2017	Impoundment of water in reservoirs and artificial lakes has reduced the outflow of water to the sea, while river runoff has increased due to groundwater mining, wetland and endorheic lake storage losses, and deforestation.	Water	83-88	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	96-99
16851561-2	2005	For each BChE-cocaine system, we simulated both the nonprereactive and prereactive complexes in water.	Water	96-101	butyrylcholinesterase	Homo sapiens	9-13
32269399-5	2017	Here, we review each component of negative and positive land water contribution separately in order to highlight and understand recent changes in land water contribution to sea level variations.	Water	151-156	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	173-176
29903160-6	2017	RESULTS: This research compared the extraction efficiency of HAV and coliphage MS2 which were added into the water samples at the same time.	Water	109-114	MS2	Homo sapiens	79-82
19791387-0	2005	Photochemistry of Mcl(H2O)4, M = H, Li, Na clusters: finite-size models of the photodetachment of the chloride anion in salt solutions.	Water	22-25	C-type lectin domain family 4 member D	Homo sapiens	18-21
19791387-1	2005	The covalent, zwitterionic and biradical forms of the MCl(H2O)4 (M = H, Li, Na) clusters have been investigated with density functional theory (DFT), time-dependent DFT (TDDFT) and the second-order Moller-Plesset (MP2) method.	Water	58-61	C-type lectin domain family 4 member D	Homo sapiens	54-57
15517891-5	2004	Two cohorts of Her2/NeuN female mice of different age (eleven-week-old and twenty-four-week-old) chronically treated with Sasa Health in drinking water showed both a delay in the development of tumors and reduced tumor multiplicity.	Water	146-151	erb-b2 receptor tyrosine kinase 2	Mus musculus	15-19
15073043-13	2004	Thus, long-term exposure of mice to arsenic in the drinking water can induce aberrant gene expression, global DNA hypomethylation, and the hypomethylation of the ER-alpha gene promoter, all of which could potentially contribute to arsenic hepatocarcinogenesis.	Water	60-65	estrogen receptor 1 (alpha)	Mus musculus	162-170
30592856-8	2017	The efficacy of lipase inactivation by supplement stored at 2-4  C in fat-water mixture has been studied.	Water	74-79	lipase, endothelial	Mus musculus	16-22
15276725-8	2004	Photodegradation of spinosyns A and D followed an order of increasing rate constants in distilled-deionized, seawater, stream and tap water under 300 nm artificial light, and was enhanced approximately 8- and 17-fold, respectively, in acetone-sensitized solution as compared to in distilled-deionized water.	Water	134-139	target of Poxn	Drosophila melanogaster	130-133
27437951-3	2016	To harness this wasted reductant, we engineered the model cyanobacterium Synechococcus PCC 7002 to express the mammalian cytochrome P450 CYP1A1 to serve as an artificial electron sink for excess electrons derived from light-catalyzed water-splitting.	Water	234-239	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	137-143
15559141-2	2004	The data on the capacity and rate of enzymatic degradation of various forms of organic matter and on the associated ecological factors in the region of active sea water/continental water interaction are given.	Water	163-168	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	159-162
15608129-3	2005	The assay is based on the release of tritium as tritiated water that occurs upon CYP2C9-mediated 4"-hydroxylation of diclofenac labeled with tritium in the 4" position.	Water	58-63	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	81-87
27318105-3	2016	Three zein-based devices are proposed for several applications: (1) inorganic phosphorus estimation in water of different sources (river, lake, coastal water and tap water) with a detection limit of 0.2mg/L - compared to at least 1mg/L required by legislation, (2) estimation of ALP in saliva and (3) chlorpyrifos control in commercial preparations.	Water	103-108	zein	Zea mays	6-10
15667209-0	2005	Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging.	Water	8-13	butyrylcholinesterase	Homo sapiens	32-53
15667209-10	2005	The nonaged hBChE structure shows one water molecule interacting with Glu197 and the catalytic triad histidine (His438).	Water	38-43	butyrylcholinesterase	Homo sapiens	12-17
27496579-0	2016	Water soluble extracts from Actinidia arguta, PG102, attenuates house dust mite-induced murine atopic dermatitis by inhibiting the mTOR pathway with Treg generation.	Water	0-5	mechanistic target of rapamycin kinase	Mus musculus	131-135
15767166-5	2005	The expanded laser beam shines on the test tube containing the tip activated in a medium of water or ophthalmic viscosurgical device (OVD).	Water	92-97	TOR signaling pathway regulator	Homo sapiens	63-66
27929386-4	2016	The percentage of added water in milk was significantly lower (SED = 1.54: p &lt; 0.001) in summer (18.59%) than in the monsoon season (26.39%).	Water	24-29	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	63-70
15703994-0	2005	Distribution of AQP2 and AQP3 water channels in human tissue microarrays.	Water	30-35	aquaporin 3 (Gill blood group)	Homo sapiens	25-29
15703994-10	2005	The abundance of basolateral AQP3 in epithelial tissues and its expression in many non-epithelial cells suggests that this aquaglyceroporin is a major participant in barrier hydration and water and osmolyte homeostasis in the human body.	Water	188-193	aquaporin 3 (Gill blood group)	Homo sapiens	29-33
27760768-1	2016	Within the past decade tremendous efforts have been made to understand the mechanism behind aquaporin-2 (AQP2) water channel trafficking and recycling, to open a path toward effective diabetes insipidus therapeutics.	Water	111-116	aquaporin 2	Rattus norvegicus	92-103
27760768-1	2016	Within the past decade tremendous efforts have been made to understand the mechanism behind aquaporin-2 (AQP2) water channel trafficking and recycling, to open a path toward effective diabetes insipidus therapeutics.	Water	111-116	aquaporin 2	Rattus norvegicus	105-109
15729817-4	2005	CSP1 can successfully resolve several chemically diverse chiral compounds, using both organic and water-based eluents (normal phase, polar organic, etc.	Water	98-103	regulator of calcineurin 1	Homo sapiens	0-4
27685324-3	2016	Enzymatic oxidation at the C-4 position was carried out anaerobically using H2O as an oxygen donor.	Water	76-79	complement C4A (Rodgers blood group)	Homo sapiens	27-30
15645048-0	2005	Rh(II) catalysed intramolecular C-H insertion of diazo substrates in water: a simple and efficient approach to catalyst reuse.	Water	69-74	Rh blood group D antigen	Homo sapiens	0-6
27628106-3	2016	METHODS: Glutathione peroxidase (GPX) 1 is an antioxidant enzyme that is abundant in the liver and converts H2O2 to water.	Water	116-121	glutathione peroxidase 1	Mus musculus	9-39
15618890-1	2005	Muller glial cells of the sensory retina mediate K+ and water fluxes that are facilitated by aquaporin-4 (AQP4) water channels and by Kir4.1-K+ channels.	Water	56-61	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	134-140
27059603-0	2016	Impact of an intense water column mixing (0-1500 m) on prokaryotic diversity and activities during an open-ocean convection event in the NW Mediterranean Sea.	Water	21-26	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	154-157
27190311-6	2016	In normal mice, vasopressin signaling induced by water deprivation increased GSK3beta expression, which decreased following rehydration.	Water	49-54	glycogen synthase kinase 3 beta	Mus musculus	77-85
15628875-2	2005	Alpha-synuclein is random in water under physiological conditions, but the first approximately 100 residues interact with SDS micelles or acidic phospholipid small unilamellar vesicles and adopt an ordered conformation.	Water	29-34	synuclein alpha	Homo sapiens	0-15
27779666-1	2016	The aim of the present study was to determine the effects of the insulin-like growth factor 1 (IGF-1)/phosphatase and tensin homologue deleted on chromosome 10 (PTEN)/Akt/forkhead box (FoxO) signaling pathway on male reproduction in rats subjected to water immersion and restraint stress (WRS).	Water	251-256	insulin-like growth factor 1	Rattus norvegicus	65-93
15516332-3	2005	For example, in Xenopus oocytes, the aquaporin-1 (AQP1) water channel is cotranslationally directed into a four membrane-spanning intermediate, which matures into the six membrane-spanning topology at a late stage of synthesis (Skach, W. R., Shi, L. B., Calayag, M. C., Frigeri, A., Lingappa, V. R., and Verkman, A. S. (1994) J.	Water	56-61	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	37-48
15516332-3	2005	For example, in Xenopus oocytes, the aquaporin-1 (AQP1) water channel is cotranslationally directed into a four membrane-spanning intermediate, which matures into the six membrane-spanning topology at a late stage of synthesis (Skach, W. R., Shi, L. B., Calayag, M. C., Frigeri, A., Lingappa, V. R., and Verkman, A. S. (1994) J.	Water	56-61	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	50-54
27779666-1	2016	The aim of the present study was to determine the effects of the insulin-like growth factor 1 (IGF-1)/phosphatase and tensin homologue deleted on chromosome 10 (PTEN)/Akt/forkhead box (FoxO) signaling pathway on male reproduction in rats subjected to water immersion and restraint stress (WRS).	Water	251-256	insulin-like growth factor 1	Rattus norvegicus	95-100
15913015-3	2005	Based on kinetic and equilibrium study results, spent activated carbon with a grain size of 0.3-0.5 mm and washed with distilled water (designated as WAC) was selected for fixed column studies.	Water	129-134	WW domain containing adaptor with coiled-coil	Homo sapiens	150-153
27863655-0	2016	Direct in vivo evidence on the mechanism by which nanoparticles facilitate the absorption of a water insoluble, P-gp substrate.	Water	95-100	phosphoglycolate phosphatase	Homo sapiens	112-116
27863655-1	2016	Here we examine the mechanisms by which nanoparticles enable the oral absorption of water-insoluble, P-glycoprotein efflux pump (P-gp) substrates, without recourse to P-gp inhibitors.	Water	84-89	phosphoglycolate phosphatase	Homo sapiens	101-127
27863655-1	2016	Here we examine the mechanisms by which nanoparticles enable the oral absorption of water-insoluble, P-glycoprotein efflux pump (P-gp) substrates, without recourse to P-gp inhibitors.	Water	84-89	phosphoglycolate phosphatase	Homo sapiens	129-133
27934241-0	2016	LIF Spectroscopy of p-Fluorophenol   Water Complex: Hydrogen Bond Vibrations, Fermi Resonance, and Vibrational Relaxation in the Excited State.	Water	37-42	LIF interleukin 6 family cytokine	Homo sapiens	0-3
15610244-3	2005	The purpose of these studies was to examine the effects of food deprivation on water handling by the kidney, the expression levels of collecting duct (CD) water channel aquaporin-2 (AQP2), and to determine the role of vasopressin in the adaptation of AQP2 to food deprivation.	Water	155-160	aquaporin 2	Rattus norvegicus	182-186
27821743-2	2016	Resulting sea level rises will not be globally uniform, due to ocean dynamical processes and changes in gravity associated with water mass redistribution.	Water	128-133	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	10-13
15637468-10	2005	AQP2 mRNA signals were significantly intensified by water restriction even in CRF rats, although the increase was limited as in the case of urine osmolality.	Water	52-57	aquaporin 2	Rattus norvegicus	0-4
15719846-4	2005	Vasopressin stimulates the V2 receptors in the kidney leading to reabsorption of water through aquaporin 2.	Water	81-86	aquaporin 2	Homo sapiens	95-106
27720326-8	2016	Further, a molecular model of the putative CCR5-MOR heterodimer was constructed, docked with the bivalent ligand, and molecular dynamics simulations of the complex was performed in a membrane-water system to help understand the biological observation.	Water	192-197	opioid receptor mu 1	Homo sapiens	48-51
27729196-19	2016	Gd3+-chelates of such ligands prove to be useful MRI contrast agents of enhanced relaxivity, greater stability, better clearance, lesser toxicity and higher water solubility.	Water	157-162	GRDX	Homo sapiens	0-3
27439180-4	2016	In addition, TPE-T was successfully used for the detection of uranyl ions in river water, illustrating its potential applications in environmental systems.	Water	83-88	T-box transcription factor 21	Homo sapiens	13-18
27785497-2	2016	The sorption behavior of Li(Na)-EMT samples towards water, methanol and a mixture of both (50 : 50) was studied by combined thermogravimetric and infrared spectroscopic methods.	Water	52-57	IL2 inducible T cell kinase	Homo sapiens	32-35
27785497-4	2016	The high sorption capacity of the Li-EMT sample towards water was demonstrated.	Water	56-61	IL2 inducible T cell kinase	Homo sapiens	37-40
27785497-5	2016	It was found that the methanol is replaced by water faster in the Li-EMT sample in comparison to the Na-EMT sample.	Water	46-51	IL2 inducible T cell kinase	Homo sapiens	69-72
27785497-5	2016	It was found that the methanol is replaced by water faster in the Li-EMT sample in comparison to the Na-EMT sample.	Water	46-51	IL2 inducible T cell kinase	Homo sapiens	104-107
27754583-4	2016	The Ni2+ , Mn2+ , and Co2+ ion-containing aqueous solution undergoes photo-induced reactions and produces hollow metal-oxide nanospheres (Ni0.18 Mn0.45 Co0.37 Ox ) or core-shell metal hydroxide nanoflowers ([Ni0.15 Mn0.15 Co0.7 (OH)2 ](NO3 )0.2  H2 O), depending on the laser wavelengths.	Water	246-250	complement C2	Homo sapiens	22-25
27267282-1	2016	A novel rhodamine-based dual probe Rh-2 for trivalent ferric ions (Fe(3+)) was successfully designed and synthesized, which exhibited a highly sensitive and selective recognition towards Fe(3+) with an enhanced fluorescence emission in methanol-water media (v/v=7/3, pH=7.2).	Water	245-250	Rh associated glycoprotein	Homo sapiens	35-39
15332974-6	2004	On the other hand, the muP(zz)T ensemble allows us to determine the interlaminar distance and water-ethane content for any specific reservoir.	Water	94-99	major urinary protein, pseudogene	Homo sapiens	23-26
27534994-1	2016	Aquaporin-2 (AQP2) is essential to maintain body water homeostasis.	Water	49-54	aquaporin 2	Mus musculus	0-11
15231853-7	2004	P12 and P27 are almost purely elastic on DD/W, TO/W, and air/water interfaces.	Water	61-66	interferon alpha inducible protein 27	Homo sapiens	8-11
27534994-1	2016	Aquaporin-2 (AQP2) is essential to maintain body water homeostasis.	Water	49-54	aquaporin 2	Mus musculus	13-17
27558157-8	2016	SLC4A11 supported osmotically driven water accumulation that was electroneutral and Na+ independent.	Water	37-42	solute carrier family 4 member 11	Homo sapiens	0-7
15115804-6	2004	Ucn 2 reduced 6-h food and water intake at doses that did not induce visceral illness (0.1, 1, and 10 microg), as indicated by kaolin intake.	Water	27-32	urocortin 2	Rattus norvegicus	0-5
27558157-14	2016	This work provides additional support for water and ammonia transport by SLC4A11.	Water	42-47	solute carrier family 4 member 11	Homo sapiens	73-80
15509855-4	2004	CrMIP1 was expressed in Saccharomyces cerevisiae and assayed for water and glycerol transport activity.	Water	65-70	uncharacterized protein	Chlamydomonas reinhardtii	0-6
27707708-12	2016	In summary, these data suggest that CD NOS3 may be involved in the diuretic response to a water load in a sex-specific manner; the mechanism of this effect remains to be determined.	Water	90-95	nitric oxide synthase 3, endothelial cell	Mus musculus	39-43
27782458-6	2016	The average water-water interactions are weakened in the sI and sII phases compared to ice.	Water	12-17	transcription elongation factor A1	Homo sapiens	64-67
15256223-6	2004	The release of HeLa cells from metaphase arrest in the presence of exogenous H(2)O(2) inhibited the ubiquitination of cyclin B1 as well as the degradation of cyclin B1 and securin that were apparent in the absence of H(2)O(2).	Water	77-82	cyclin B1	Homo sapiens	118-127
15256223-6	2004	The release of HeLa cells from metaphase arrest in the presence of exogenous H(2)O(2) inhibited the ubiquitination of cyclin B1 as well as the degradation of cyclin B1 and securin that were apparent in the absence of H(2)O(2).	Water	77-82	cyclin B1	Homo sapiens	158-167
27782458-6	2016	The average water-water interactions are weakened in the sI and sII phases compared to ice.	Water	18-23	transcription elongation factor A1	Homo sapiens	64-67
15256223-6	2004	The release of HeLa cells from metaphase arrest in the presence of exogenous H(2)O(2) inhibited the ubiquitination of cyclin B1 as well as the degradation of cyclin B1 and securin that were apparent in the absence of H(2)O(2).	Water	77-82	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	172-179
27474578-3	2016	Four water-soluble polysaccharides named as BP1-1, BP1-2, BP1-3 and BP1-4, with molecular weight of 35.8, 32.4, 30.1 and 27.7kDa, were purified by DEAE Sepharose and Superdex 200 chromatography.	Water	5-10	BP14	Homo sapiens	68-73
27696799-3	2016	In this letter, a kind of noncorrosive and water-stable ionic liquid obtained by mixing 1-butyl-3-methylimidazolium trifluoromethanesulfonate ([BMIM]OTF) with the corresponding aluminum salt (Al(OTF)3) is studied.	Water	43-48	POU class 5 homeobox 1	Homo sapiens	195-200
15133035-7	2004	We also show that MTH1 catalyzes hydrolysis of 8-oxo-dGTP through nucleophilic substitution of water at the beta-phosphate.	Water	95-100	nudix hydrolase 1	Homo sapiens	18-22
15251293-6	2004	Strong correlations between water and sediment with 10(5.2) of the mean partition coefficient (Koc ) were observed.	Water	28-33	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	95-98
15284286-3	2004	Toward this end, the expression and regulation of AE1 and SLC26A7 was examined in water deprivation, a condition known to increase the osmolality of the medulla.	Water	82-87	solute carrier family 4 member 1 (Diego blood group)	Rattus norvegicus	50-53
27711502-1	2016	Investigations carried out at MP2 and CCSD(T) levels of theory show that water dimers can compete with formic and sulfuric acids in catalyzing the isomerization of methoxy radicals in the lower troposphere.	Water	73-78	tryptase pseudogene 1	Homo sapiens	30-33
15236479-0	2004	Water-dispersed bone morphogenetic protein nanospheres prepared by co-precipitation method.	Water	0-5	bone morphogenetic protein 1	Homo sapiens	16-42
27565214-0	2016	Diffusion of water-soluble sorptive drugs in HEMA/MAA hydrogels.	Water	13-18	MAA	Homo sapiens	50-53
27667798-0	2016	Nitrogen, Phosphorus, and Fluorine Tri-doped Graphene as a Multifunctional Catalyst for Self-Powered Electrochemical Water Splitting.	Water	117-122	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	35-38
15223380-2	2004	Here, we report that, when PSAPP mice receive a regimen of anti-CD40L antibody commencing at an age associated with initial Abeta deposition, they demonstrate superior spatial memory on the standard water maze and radial arm water maze tasks, as well as exhibiting superior non-spatial memory in the object recognition test, as compared to control PSAPP mice.	Water	199-204	CD40 ligand	Mus musculus	64-69
15223380-2	2004	Here, we report that, when PSAPP mice receive a regimen of anti-CD40L antibody commencing at an age associated with initial Abeta deposition, they demonstrate superior spatial memory on the standard water maze and radial arm water maze tasks, as well as exhibiting superior non-spatial memory in the object recognition test, as compared to control PSAPP mice.	Water	225-230	CD40 ligand	Mus musculus	64-69
15223380-3	2004	Furthermore, PSAPP mice treated with an anti-CD40L antibody regimen commencing at an age associated with extensive Abeta deposition demonstrate superior spatial memory on the standard water maze task, as compared to control PSAPP mice.	Water	184-189	CD40 ligand	Mus musculus	45-50
27411680-5	2016	CONCLUSIONS: In the semi-arid Australian environment, grain yield impacts from storage and uptake of water from depth (&gt;1 m) could be influenced to a stronger degree by preceding crop choice (0 42 t ha-1), pre-crop fallow management (0 65 t ha-1) and sowing date (0 63 t ha-1) than by current genetic differences in rooting depth (0 36 t ha-1).	Water	101-106	plasma membrane ATPase	Triticum aestivum	202-206
15276323-2	2004	Peroxiredoxin 5 (PRDX5) is a novel thioredoxin peroxidase recently identified in mammals, participating directly in eliminating hydrogen peroxide (H(2)O(2)) and neutralizing other reactive oxygen species (ROS).	Water	147-152	peroxiredoxin 5	Homo sapiens	0-15
15276323-2	2004	Peroxiredoxin 5 (PRDX5) is a novel thioredoxin peroxidase recently identified in mammals, participating directly in eliminating hydrogen peroxide (H(2)O(2)) and neutralizing other reactive oxygen species (ROS).	Water	147-152	peroxiredoxin 5	Homo sapiens	17-22
15216331-1	2004	Soft, water-filled polymer nanotubes of several tens of microm in length have been prepared via self-assembly of amphiphilic ABA-triblock macromonomers in aqueous media; the tubes are mechanically and chemically stable and can be loaded with water-soluble substances.	Water	242-247	POC1 centriolar protein A	Homo sapiens	0-4
15196935-1	2004	Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis.	Water	24-29	aquaporin 2	Mus musculus	38-49
15196935-1	2004	Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis.	Water	24-29	aquaporin 2	Mus musculus	51-55
15196935-2	2004	Trafficking of AQP2 to the apical membrane is critical to the reabsorption of water in renal collecting ducts.	Water	78-83	aquaporin 2	Mus musculus	15-19
14996671-8	2004	These findings are the first to identify SCCD in the vestibular labyrinth as a site of physiologically significant ENaC-mediated Na(+) absorption and osmotically coupled water flux.	Water	170-175	UbiA prenyltransferase domain containing 1	Homo sapiens	41-45
15189329-2	2004	The current studies were performed to determine whether other pathways that stimulate AVP release, such as hypovolaemia, also regulate ER-beta expression in these nuclei, and to evaluate the time course of the change in ER-beta expression during water deprivation and subsequent rehydration.	Water	246-251	estrogen receptor 2	Rattus norvegicus	220-227
15189329-5	2004	ER-beta was also significantly depleted following 20 h and 26 h of water deprivation in SON (P = 0.003) and magnocellular PVN (P &lt; 0.001).	Water	67-72	estrogen receptor 2	Rattus norvegicus	0-7
16203098-0	2005	Lead induces increased water permeability in astrocytes expressing aquaporin 4.	Water	23-28	aquaporin 4	Rattus norvegicus	67-78
16203098-4	2005	Here we report that lead increases AQP4 water permeability (P(f)) in astrocytes.	Water	40-45	aquaporin 4	Rattus norvegicus	35-39
16203098-7	2005	AQP4-expressing astrocytes had a three-fold higher water permeability than astrocytes not expressing AQP4.	Water	51-56	aquaporin 4	Rattus norvegicus	0-4
16203098-8	2005	Lead exposure induced a significant, 40%, increase in water permeability in astrocytes expressing AQP4, but had no effect on P(f) in astrocytes not expressing AQP4.	Water	54-59	aquaporin 4	Rattus norvegicus	98-102
16203098-15	2005	It is suggested that lead-triggered stimulation of water transport in AQP4-expressing astrocytes may contribute to the pathology of acute lead intoxication.	Water	51-56	aquaporin 4	Rattus norvegicus	70-74
15923781-10	2005	This is done by means of a case study related to the integration of the regulation of water function of AQP2 channels (genomic, proteomic and cellular levels) into a kidney collecting duct epithelium mathematical model of a PPI.	Water	86-91	aquaporin 2	Homo sapiens	104-108
16114617-5	2005	The Black Sea River Basin Directorate in Varna is one of four Directorates established in Bulgaria in 2002 in accordance with the Bulgarian Water Act and is the regional operational unit under the Ministry of Environment and Water for the Black Sea Basin catchment area.	Water	140-145	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	10-13
15541344-6	2004	We studied the effects of the water- and lipid-soluble derivatives of alpha-trinositol on the FGF-2- and/or FGF-8-induced proliferation of human pulmonary artery smooth muscle cells (HPASMC) and S115 mouse breast cancer cells.	Water	30-35	fibroblast growth factor 8	Homo sapiens	108-113
15568076-0	2004	Supramolecular control of complexation-induced fluorescence change of water-soluble, beta-cyclodextrin-modified CdS quantum dots.	Water	70-75	CDP-diacylglycerol synthase 1	Homo sapiens	112-115
15575899-5	2004	Most genes were categorized in different functional groups: metabolism/transport (including the down-regulated water channel Aqp-2), inflammation/coagulation (containing the largest number (16) of up-regulated genes including selectins, Il-6, alpha- and beta-fibrinogen), cell division/fibrosis (including KIM-1 involved in tubular regeneration) and defense/repair (with the cytoprotective genes HO-1, Hsp70, MnSOD2).	Water	111-116	aquaporin 2	Homo sapiens	125-130
15636531-7	2004	This work proposes that using the NBN platform allows the direct monitoring and control of contaminated water for Cd by ETAAS without any chemical modification.	Water	104-109	nibrin	Homo sapiens	34-37
15579502-1	2004	The effect of nonsteroidal antiinflammatory drugs on the regulation of aquaporin-2 (AQP2) water channels in the kidney was determined.	Water	90-95	aquaporin 2	Rattus norvegicus	71-82
15579502-1	2004	The effect of nonsteroidal antiinflammatory drugs on the regulation of aquaporin-2 (AQP2) water channels in the kidney was determined.	Water	90-95	aquaporin 2	Rattus norvegicus	84-88
15614025-1	2004	OBJECTIVE: Angiotensin II and aldosterone, generated by the angiotensin-converting enzyme (ACE) and aldosterone synthase (CYP11B2), respectively, not only regulate sodium and water homeostasis, but also influence vascular remodeling in response to high blood pressure.	Water	175-180	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	100-120
15614025-1	2004	OBJECTIVE: Angiotensin II and aldosterone, generated by the angiotensin-converting enzyme (ACE) and aldosterone synthase (CYP11B2), respectively, not only regulate sodium and water homeostasis, but also influence vascular remodeling in response to high blood pressure.	Water	175-180	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	122-129
15538275-1	2004	PURPOSE: Renal obstruction causes impairment of urinary concentrating ability, partly by decreasing aquaporin-2 (AQP-2) water channel level in the collecting ducts.	Water	120-125	aquaporin 2	Rattus norvegicus	100-111
15538275-1	2004	PURPOSE: Renal obstruction causes impairment of urinary concentrating ability, partly by decreasing aquaporin-2 (AQP-2) water channel level in the collecting ducts.	Water	120-125	aquaporin 2	Rattus norvegicus	113-118
15538275-12	2004	CONCLUSIONS: These findings suggest that COX-2 mediated prostaglandin has an important role in the down-regulation of AQP-2 water channel level in the medullary collecting duct cells after ureteral obstruction.	Water	124-129	aquaporin 2	Rattus norvegicus	118-123
15569313-2	2004	In this study, we tested the hypothesis that hypercalciuria-associated polyuria in kidney collecting duct occurs through an impairment of the vasopressin-dependent aquaporin 2 (AQP2) water channel targeting to the apical membrane possibly involving calcium-sensing receptor (CaR) signaling.	Water	183-188	aquaporin 2	Homo sapiens	164-175
15569313-2	2004	In this study, we tested the hypothesis that hypercalciuria-associated polyuria in kidney collecting duct occurs through an impairment of the vasopressin-dependent aquaporin 2 (AQP2) water channel targeting to the apical membrane possibly involving calcium-sensing receptor (CaR) signaling.	Water	183-188	aquaporin 2	Homo sapiens	177-181
15236299-5	2004	A complete mechanistic scheme, based on MP2/6-31G* calculations, is proposed; it involves isomerization of the various protonated forms of LA and the passage through the ion-neutral complex between the 2-hydroxypropyl acylium cation and a water molecule.	Water	239-244	tryptase pseudogene 1	Homo sapiens	40-43
15178366-3	2004	The aim of the present study was to investigate the effects of 5-aminoisoquinolinone (5-AIQ), a potent water-soluble inhibitor of poly(ADP-ribose) polymerase (PARP), in the pathogenesis of splanchnic artery occlusion shock.	Water	103-108	poly (ADP-ribose) polymerase 1	Rattus norvegicus	130-157
15178366-3	2004	The aim of the present study was to investigate the effects of 5-aminoisoquinolinone (5-AIQ), a potent water-soluble inhibitor of poly(ADP-ribose) polymerase (PARP), in the pathogenesis of splanchnic artery occlusion shock.	Water	103-108	poly (ADP-ribose) polymerase 1	Rattus norvegicus	159-163
15178366-11	2004	In conclusion, these results show that 5-AIQ, a new water-soluble potent inhibitor of poly(ADP-ribose) polymerase, exerts multiple protective effects in splanchnic artery occlusion/reperfusion shock.	Water	52-57	poly (ADP-ribose) polymerase 1	Rattus norvegicus	86-113
27411680-5	2016	CONCLUSIONS: In the semi-arid Australian environment, grain yield impacts from storage and uptake of water from depth (&gt;1 m) could be influenced to a stronger degree by preceding crop choice (0 42 t ha-1), pre-crop fallow management (0 65 t ha-1) and sowing date (0 63 t ha-1) than by current genetic differences in rooting depth (0 36 t ha-1).	Water	101-106	plasma membrane ATPase	Triticum aestivum	244-248
27411680-5	2016	CONCLUSIONS: In the semi-arid Australian environment, grain yield impacts from storage and uptake of water from depth (&gt;1 m) could be influenced to a stronger degree by preceding crop choice (0 42 t ha-1), pre-crop fallow management (0 65 t ha-1) and sowing date (0 63 t ha-1) than by current genetic differences in rooting depth (0 36 t ha-1).	Water	101-106	plasma membrane ATPase	Triticum aestivum	244-248
15969416-2	2004	Two TTF units were linked via [24]crown-8, [21]crown-7, and [18]crown-6 macrocycles, forming charge-transfer (CT) salts with 2,3,5,6-tetrafluoro-7,7,8,8-tetracyano-p-quinodimethane (F4-TCNQ) at the air-water interface and on solid substrates.	Water	202-207	ras homolog family member H	Homo sapiens	4-7
15469988-1	2004	Binding of arginine-vasopressin (AVP) to its V2 receptor (V2R) in the basolateral membrane of principal cells induces Aquaporin-2-mediated water reabsorption in the kidney.	Water	139-144	aquaporin 2	Homo sapiens	118-129
27411680-5	2016	CONCLUSIONS: In the semi-arid Australian environment, grain yield impacts from storage and uptake of water from depth (&gt;1 m) could be influenced to a stronger degree by preceding crop choice (0 42 t ha-1), pre-crop fallow management (0 65 t ha-1) and sowing date (0 63 t ha-1) than by current genetic differences in rooting depth (0 36 t ha-1).	Water	101-106	plasma membrane ATPase	Triticum aestivum	244-248
27494348-4	2016	The optimised method was applied to the analysis of 11 water-based pen inks and the determination of their metal composition.	Water	55-60	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	67-70
15530741-6	2004	Results support further evaluation of VapA protein antigen associated with a water-based nanoparticle adjuvant as a candidate vaccine for immunization of pregnant mares resulting in passive antibody-mediated protection of foals.	Water	77-82	virulence-associated 15-17 kDa antigen	Rhodococcus equi	38-42
15224873-1	2004	OBJECTIVE: To detect and localize aquaporin-2 (AQP-2), a water channel regulated by the antidiuretic hormone, in human endolymphatic sac.	Water	57-62	aquaporin 2	Homo sapiens	34-45
15224873-1	2004	OBJECTIVE: To detect and localize aquaporin-2 (AQP-2), a water channel regulated by the antidiuretic hormone, in human endolymphatic sac.	Water	57-62	aquaporin 2	Homo sapiens	47-52
26224170-7	2016	Furthermore, STMP increased the glass transition temperature and decreased the water uptake of ~50% of the hydrogels, which can be explained by the crosslinking of PVA chains.	Water	79-84	STEAP2 metalloreductase	Homo sapiens	13-17
15078916-9	2004	Alkaline pH increased the water permeability of AQP4 that contains His at position 129 in loop C. Acid and alkaline pH sensitivity was induced in AQP1 by adding histidines 48 (in loop A) and 130 (in loop C).	Water	26-31	aquaporin 4	Bos taurus	48-52
15522720-3	2004	Based on the recognition property of the multiple tetracycline imprinted polymer (MIP-1), the polymer was applied in affinity membrane extraction as a class-selective adsorption phase to remove tetracyclines residues from water.	Water	222-227	transportin 1	Homo sapiens	82-87
15339918-1	2004	Aldoxime dehydratase (OxdA), which is a novel heme protein, catalyzes the dehydration of an aldoxime to a nitrile even in the presence of water in the reaction mixture.	Water	138-143	D-amino acid oxidase	Homo sapiens	22-26
15065850-1	2004	trans-3-Chloroacrylic acid dehalogenase (CaaD) converts trans-3-chloroacrylic acid to malonate semialdehyde by the addition of H(2)O to the C-2, C-3 double bond, followed by the loss of HCl from the C-3 position.	Water	127-132	complement C2	Homo sapiens	140-143
27629350-2	2016	Specifically, we apply a previously described protocol that incorporates explicit water molecules in the ligand binding site to prospectively screen over 2.5 million drug-like and lead-like compounds from the commercially available eMolecules database in search of novel binders to the adenosine A2A receptor (A2AAR).	Water	82-87	adenosine A2a receptor	Homo sapiens	286-308
15039298-0	2004	Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase.	Water	32-37	myeloperoxidase	Rattus norvegicus	87-102
27419667-4	2016	This structural comparison revealed that the conformation of TN1-Fab does not substantially change after hTPO binding and a set of 15 water molecules is released from the antigen-binding site (paratope) of TN1-Fab upon hTPO complexation.	Water	134-139	FA complementation group B	Homo sapiens	210-213
15034115-4	2004	They proved that aquaporin-1 is a specific water channel by cRNA expression studies in Xenopus oocytes and by functional reconstitution of transport activity in liposomes after the incorporation of the purified protein.	Water	43-48	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	17-28
15347663-5	2004	The expression of AQP2 and UT-A1, but not UT-A2 mRNAs, was increased to the same level as that of the wild type mice in the water deprivation state, indicating that the vasopressin regulatory mechanism was not affected by OREBPdn.	Water	124-129	aquaporin 2	Mus musculus	18-22
15095558-1	2004	Continuous arterial spin labeling perfusion magnetic resonance imaging (CASL-pMRI) uses magnetically labeled arterial blood water as a tracer to obtain quantifiable measurements of cerebral blood flow (CBF) (mL/100 g-1/min-1).	Water	124-129	CCAAT enhancer binding protein zeta	Homo sapiens	181-224
27281037-5	2016	After 12 months of water-ageing, NACP-QADM-NAg had a flexural strength and elastic modulus matching those of the commercial control (P&gt;0.1).	Water	19-24	synuclein alpha	Homo sapiens	33-37
14991736-5	2004	By fitting a model of water transport to the experimentally obtained data, the best-fit water transport parameters (L(pg) and E(Lp)) were determined.	Water	22-27	nuclear receptor subfamily 5 group A member 1	Homo sapiens	126-131
15374630-5	2004	Supplementation of Apc(min) mice with 10% PEG 3350 (in drinking water) resulted in a 48% (P&lt;0.05) reduction in intestinal tumor burden and induced 2-3 fold increase in mucosal apoptosis.	Water	64-69	APC, WNT signaling pathway regulator	Mus musculus	19-22
15530067-3	2004	Therefore, we introduced PEG to engineer a nontoxic and highly transfection efficient polymeric gene carrier because PEG is known to convey water-solubility and biocompatibility to the conjugated copolymer.	Water	140-145	progestagen associated endometrial protein	Homo sapiens	25-28
15530067-3	2004	Therefore, we introduced PEG to engineer a nontoxic and highly transfection efficient polymeric gene carrier because PEG is known to convey water-solubility and biocompatibility to the conjugated copolymer.	Water	140-145	progestagen associated endometrial protein	Homo sapiens	117-120
14991736-5	2004	By fitting a model of water transport to the experimentally obtained data, the best-fit water transport parameters (L(pg) and E(Lp)) were determined.	Water	88-93	nuclear receptor subfamily 5 group A member 1	Homo sapiens	126-131
32263488-4	2016	In water, in rat plasma and in the solid state DHDMIQK(KAP) formed nanoparticles of a size capable of suitable delivery in the blood circulation.	Water	3-8	kidney androgen regulated protein	Rattus norvegicus	47-59
15192085-7	2004	In the water maze test for spatial learning, APP/PS1 mice had longer escape latencies to both hidden and visible platforms, but they did not differ from NT mice in their swimming speed.	Water	7-12	presenilin 1	Mus musculus	49-52
14676193-9	2004	A network of hydrogen-bonded water molecules, found in crystal structures of GSTP1-1, connects the two active sites and the main chain carbonyl group of Tyr(50), thereby offering a mechanism for communication between the two active sites.	Water	29-34	glutathione S-transferase pi 1	Homo sapiens	77-84
15192085-8	2004	Memantine significantly improved the acquisition of the water maze in APP/PS1 mice without affecting swimming speed.	Water	56-61	presenilin 1	Mus musculus	74-77
27658444-5	2016	Relationships between the DOC and the principal component scores of the surface waters of the southern Chukchi Sea implied that the major factor controlling the distribution of DOC concentrations was the mixing of plural water masses rather than local production and degradation.	Water	80-85	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	111-114
29964784-13	2016	The desorption of Cd2+ from the EDTA-nSiO2 nanoparticles was carried out with distilled water, 0.1 mol L-1 NaCl and 0.1 mol L-1 HCl.	Water	88-93	CD2 molecule	Homo sapiens	18-21
15292263-12	2004	Thus, the Rap.RapGAP catalytic machinery compensates for the absence of a cis-Gln by a trans-Asn and for the catalytic Arg by inducing a different GTP conformation that is more prone to be attacked by a water molecule.	Water	203-208	LDL receptor related protein associated protein 1	Homo sapiens	10-13
15316017-7	2004	Kinetic analysis with four phosphatidylinositol lipids bearing a 5-phosphate and 54 water-soluble inositol phosphates reveals that SP-synaptojanin and SHIP2 possess much broader substrate specificity than previously appreciated.	Water	84-89	inositol polyphosphate phosphatase like 1	Homo sapiens	151-156
14604844-5	2004	Water deprivation eliminated ER-beta-immunoreactivity (-ir) in SON and magnocellular PVN of sham-lesioned animals.	Water	0-5	estrogen receptor 2	Rattus norvegicus	29-36
14745470-3	2004	The water was later homogenized in the NRC laboratories in Ottawa and stabilized via gamma irradiation.	Water	4-9	nuclear receptor coactivator 6	Homo sapiens	39-42
27574849-0	2016	Rosae Multiflorae Fructus Hot Water Extract Inhibits a Murine Allergic Asthma Via the Suppression of Th2 Cytokine Production and Histamine Release from Mast Cells.	Water	30-35	heart and neural crest derivatives expressed 2	Mus musculus	101-104
14966990-2	2004	Application of this technique to the heterotrimetallic sandwich complexes [LnLu2(TACI-3H)2(H2O)6]3+, which possess a single C2v-symmetrical paramagnetic center, unambiguously evidences isostructurality for Ln = Pr-Yb, while the variation of the second-rank crystal-field parameters and along the series prevents reliable structural analyses with the classical one-nucleus equation.	Water	91-94	TNF receptor superfamily member 13B	Homo sapiens	81-85
15453736-0	2004	A diamondoid network of tetrakis(acetamidato)dirhodium in mixed oxidation states linked by mu4-iodide having a 10(5) enhancement of its electrical conductivity by water molecules of hydration.	Water	163-168	adaptor related protein complex 4 subunit mu 1	Homo sapiens	91-94
15248066-3	2004	In the thiourea group, lung water content increased significantly (vs. controls) with the peak at around 4 h. Semi-quantitative RT-PCR showed that AQP3 mRNA in the thiourea group rose significantly, peaking at around 4-8 h. The expression of AQP1, AQP4, AQP5, ENaC and CFTR mRNA each decreased significantly some time after the peak in lung water content.	Water	28-33	aquaporin 3 (Gill blood group)	Rattus norvegicus	147-151
15248066-3	2004	In the thiourea group, lung water content increased significantly (vs. controls) with the peak at around 4 h. Semi-quantitative RT-PCR showed that AQP3 mRNA in the thiourea group rose significantly, peaking at around 4-8 h. The expression of AQP1, AQP4, AQP5, ENaC and CFTR mRNA each decreased significantly some time after the peak in lung water content.	Water	341-346	aquaporin 3 (Gill blood group)	Rattus norvegicus	147-151
15252532-0	2004	[Ru(TAP)2(dppz)]2+: a DNA intercalating complex, which luminesces strongly in water and undergoes photo-induced proton-coupled electron transfer with guanosine-5"-monophosphate.	Water	78-83	antigen peptide transporter 2	Bos taurus	4-9
27206969-7	2016	Interestingly, genetic inactivation of beta3-AR in mice was associated with significantly increased urine excretion of water, sodium, potassium, and chloride.	Water	119-124	adrenergic receptor, beta 3	Mus musculus	39-47
14561591-1	2004	In mammals, the regulation of water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which localizes to the basolateral and apical membranes of the early nephron segment, and AQP2, which is translocated from intracellular vesicles to the apical membrane of collecting duct cells after vasopressin stimulation.	Water	30-35	aquaporin-1	Canis lupus familiaris	67-78
14561591-1	2004	In mammals, the regulation of water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which localizes to the basolateral and apical membranes of the early nephron segment, and AQP2, which is translocated from intracellular vesicles to the apical membrane of collecting duct cells after vasopressin stimulation.	Water	30-35	aquaporin-1	Canis lupus familiaris	80-84
14561591-1	2004	In mammals, the regulation of water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which localizes to the basolateral and apical membranes of the early nephron segment, and AQP2, which is translocated from intracellular vesicles to the apical membrane of collecting duct cells after vasopressin stimulation.	Water	30-35	aquaporin 2	Canis lupus familiaris	191-195
14561591-1	2004	In mammals, the regulation of water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which localizes to the basolateral and apical membranes of the early nephron segment, and AQP2, which is translocated from intracellular vesicles to the apical membrane of collecting duct cells after vasopressin stimulation.	Water	86-91	aquaporin-1	Canis lupus familiaris	67-78
15313212-0	2004	Myosin-induced volume increase of the hyper-mobile water surrounding actin filaments.	Water	51-56	myosin heavy chain 14	Homo sapiens	0-6
14561591-1	2004	In mammals, the regulation of water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which localizes to the basolateral and apical membranes of the early nephron segment, and AQP2, which is translocated from intracellular vesicles to the apical membrane of collecting duct cells after vasopressin stimulation.	Water	86-91	aquaporin-1	Canis lupus familiaris	80-84
27206969-8	2016	Stimulation of beta3-AR significantly reduced urine excretion of water and the same electrolytes.	Water	65-70	adrenergic receptor, beta 3	Mus musculus	15-23
15313212-5	2004	We report here that the volume of this water component (hyper-mobile water) markedly increases without significant change of the volume of the ordinary hydration shell when the myosin motor-domain (S1, myosin subfragment-1) binds to F-actin.	Water	39-44	myosin heavy chain 14	Homo sapiens	177-183
27364478-8	2016	However, Trpv4 (-/-) mice showed a significantly lower vasopressin synthesis and release after water deprivation, with a loss of the positive correlation between plasma osmolality and plasma vasopressin levels, and a delayed water intake upon acute administration of hypertonic saline.	Water	95-100	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	9-14
15313212-5	2004	We report here that the volume of this water component (hyper-mobile water) markedly increases without significant change of the volume of the ordinary hydration shell when the myosin motor-domain (S1, myosin subfragment-1) binds to F-actin.	Water	39-44	myosin heavy chain 14	Homo sapiens	202-208
15332928-1	2004	All-atom molecular dynamics simulations for a single molecule of Leu-Enkephalin in aqueous solution have been used to study the role of the water network during the formation of beta-turns.	Water	140-145	prodynorphin	Homo sapiens	65-79
14673023-5	2004	Salt and water stresses induced the accumulation of ZmTIP2-3 transcripts.	Water	9-14	aquaporin TIP2-3	Zea mays	52-60
27364478-8	2016	However, Trpv4 (-/-) mice showed a significantly lower vasopressin synthesis and release after water deprivation, with a loss of the positive correlation between plasma osmolality and plasma vasopressin levels, and a delayed water intake upon acute administration of hypertonic saline.	Water	225-230	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	9-14
27553039-9	2016	CONCLUSIONS: The data indicate Wnt3a ND constitute a water-soluble transport vehicle capable of promoting ex vivo expansion of HSPC.	Water	53-58	wingless-type MMTV integration site family, member 3A	Mus musculus	31-36
15267918-1	2004	The MP2 complete basis set (CBS) limit for the binding energy of the two low-lying water octamer isomers of D2d and S4 symmetry is estimated at -72.7+/-0.4 kcal/mol using the family of augmented correlation-consistent orbital basis sets of double through quintuple zeta quality.	Water	83-88	tryptase pseudogene 1	Homo sapiens	4-7
15267918-4	2004	The newly established MP2/CBS limit for the water octamer is reproduced quite accurately by the newly developed all atom polarizable, flexible interaction potential (TTM2-F).	Water	44-49	tryptase pseudogene 1	Homo sapiens	22-25
14704128-0	2004	Effects of acetazolamide and anordiol on osmotic water permeability in AQP1-cRNA injected Xenopus oocyte.	Water	49-54	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	71-75
14704128-1	2004	AIM: To study the effects of acetazolamide and anordiol on osmotic water permeability in aquaporin 1 (AQP1)-cRNA injected Xenopus oocyte and their mechanisms.	Water	67-72	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	89-100
14704128-1	2004	AIM: To study the effects of acetazolamide and anordiol on osmotic water permeability in aquaporin 1 (AQP1)-cRNA injected Xenopus oocyte and their mechanisms.	Water	67-72	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	102-106
14704128-3	2004	The effects of acetazolamide and anordiol on the water transport function of AQP1 were observed by assaying the osmotic swelling of oocytes.	Water	49-54	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	77-81
15126246-2	2004	Water deprivation increased the B(max) of glomerular binding sites for ANP(1-28) and C-type natriuretic peptide (CNP)(1-22) without modifying their affinity, an effect that was prevented in the presence of C-atrial natriuretic factor (C-ANF), suggesting that natriuretic peptide receptor-C (NPR-C) binding sites might be enhanced.	Water	0-5	natriuretic peptide receptor 3	Rattus norvegicus	259-289
15126246-2	2004	Water deprivation increased the B(max) of glomerular binding sites for ANP(1-28) and C-type natriuretic peptide (CNP)(1-22) without modifying their affinity, an effect that was prevented in the presence of C-atrial natriuretic factor (C-ANF), suggesting that natriuretic peptide receptor-C (NPR-C) binding sites might be enhanced.	Water	0-5	natriuretic peptide receptor 3	Rattus norvegicus	291-296
15126246-5	2004	Our observations suggest that this effect must be attributed to the 67-kDa NPR-C-like protein, because the 67- and 77-kDa NPR-C-like proteins show high and low affinities for CNP(1-22), respectively, and the enhanced inhibitory effect of CNP on cAMP generation in water-deprived rats was detected at subnanomolar concentrations.	Water	264-269	natriuretic peptide receptor 3	Rattus norvegicus	75-80
15126246-5	2004	Our observations suggest that this effect must be attributed to the 67-kDa NPR-C-like protein, because the 67- and 77-kDa NPR-C-like proteins show high and low affinities for CNP(1-22), respectively, and the enhanced inhibitory effect of CNP on cAMP generation in water-deprived rats was detected at subnanomolar concentrations.	Water	264-269	natriuretic peptide receptor 3	Rattus norvegicus	122-127
14704128-5	2004	RESULTS: After incubation for 15 min or 72 h, acetazolamide, a carbonic anhydrase inhibitor, equally reduced the water permeability of AQP1-cRNA injected oocyte in a dose-dependent manner.	Water	113-118	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	135-139
14704128-9	2004	CONCLUSION: Both acetazolamide and anordiol inhibited the osmotic water permeability of AQP1-cRNA injected oocyte, but their mechanisms were different.	Water	66-71	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	88-92
14704128-10	2004	Acetazolamide functionally inhibited the osmotic water permeability of AQP1, whereas anordiol primarily decreased the amount of AQP1 protein in the oocyte membrane.	Water	49-54	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	71-75
27460867-6	2016	However, binding of ADP breaks this ionic lock, forming a continuous water channel that leads to P2Y1 R activation.	Water	69-74	purinergic receptor P2Y1	Homo sapiens	97-101
14694471-0	2004	Dynamics of ordered water in interfacial enzyme recognition: bovine pancreatic phospholipase A2.	Water	20-25	LOC104974671	Bos taurus	79-95
27252474-6	2016	When TRPV4 activity was blocked with a specific antagonist HC-067047, water intake by WT mice was significantly reduced, whereas intake by TRPV4-KO and Nax-KO mice was not.	Water	70-75	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	5-10
27252474-9	2016	These results suggest that the Na(+) signal generated in Nax-positive glial cells leads to the activation of TRPV4-positive neurons in sCVOs to stimulate water intake by using EETs as gliotransmitters.	Water	154-159	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	109-114
14732820-1	2004	Dialysis fluid produced by state-of-the-art water preparation and distribution is contaminated with gram-negative bacteria and cytokine-inducing substances (CIS) derived from these microorganisms.	Water	44-49	cytokine inducible SH2 containing protein	Homo sapiens	127-155
27055721-5	2016	The addition of 4-aminomethylbenzoic acid, an inhibitor of PepT1, significantly suppressed WPH"s enhancement of water absorption (p &lt; 0.05).	Water	112-117	solute carrier family 15 member 1	Rattus norvegicus	59-64
26868517-1	2016	The concentration of MS2 phage as a model RNA virus in river water using a combined ferric colloid adsorption and foam separation-based method was examined.	Water	61-66	MS2	Homo sapiens	21-24
14720586-0	2004	An aromatase inhibitor or high water temperature induce oocyte apoptosis and depletion of P450 aromatase activity in the gonads of genetic female zebrafish during sex-reversal.	Water	31-36	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	90-104
17271524-4	2004	The wet-cell allows the addition of water containing ATP and the necessary ions to activate the myosin biomolecules.	Water	36-41	myosin heavy chain 14	Homo sapiens	96-102
26868517-5	2016	Furthermore, based on the analysis of the collected ferric colloid dissolved using deferoxamine, the MS2 concentration in the colloid-dissolved solution was 190-fold higher than that found in raw water according to RT-qPCR analysis.	Water	196-201	MS2	Homo sapiens	101-104
27600972-2	2016	The objective of the present study was to examine the ability of water soluble extracts (WSE) obtained from traditional Greek yoghurt made from bovine or ovine milk to modulate the expression of u-PA, u-PAR, PAI-1 and PAI-2 in ovine monocytes and neutrophils.	Water	65-70	plasminogen activator, urokinase	Bos taurus	195-199
15887373-6	2004	It was found that morphology, the proximity to sources of nutrient loading from land, nutrient uptake and the infrequent water exchange between the Baltic Sea in the south and the Skagerrak in the north all contribute to create distinct regions of water quality.	Water	121-126	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	155-158
15887373-6	2004	It was found that morphology, the proximity to sources of nutrient loading from land, nutrient uptake and the infrequent water exchange between the Baltic Sea in the south and the Skagerrak in the north all contribute to create distinct regions of water quality.	Water	248-253	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	155-158
27222923-0	2016	MicroRNA-128-3p impaired water maze learning by suppressing Doublecortin expression in both wild type and Abeta-42 infused mice.	Water	25-30	doublecortin	Mus musculus	60-72
27411017-1	2016	Complexation of calcium chloride with bis(lactam) ligand L1 allows the formation of both an unstable anhydrous complex, an aqua complex {[Ca2(mu-L1)2(H2O)9]Cl4]}n (1) and a related hydrate incorporating additional lattice water of crystallization {[Ca(mu-L1)(H2O)5]Cl2 H2O}n (2).	Water	222-227	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	142-147
14752829-6	2004	In nontransfected NMCs, the transcellular water flow, P(f), value was relatively high (i.e., 16.4 +/- 3.2 microm/sec) and likely was a reflection of endogenous expression of AQP1 and AQP8.	Water	42-47	aquaporin 8	Mus musculus	183-187
27459093-7	2016	These modifications were concomitant to the activation of Aegean Sea as a source of dense water formation as part of the "Eastern Mediterranean Transient-like" event.	Water	90-95	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	65-68
15314257-4	2004	The cholesterol-induced accumulation of Abeta in rabbit brain is increased when distilled drinking water is supplemented with 0.12 ppm copper ion (as copper sulfate) compared to the cholesterol-induced accumulation of Abeta in rabbit brain of animals given unaltered distilled water.	Water	277-282	amyloid beta (A4) precursor protein	Mus musculus	40-45
15314257-5	2004	The numbers of affected neurons and the intensity of neuronal Abeta immunoreactivity is consistently increased among animals administered the copper ion in their drinking water.	Water	171-176	amyloid beta (A4) precursor protein	Mus musculus	62-67
15314257-8	2004	The data suggest that there is an accumulation of fibrillar Abeta induced in the brains of rabbits fed a cholesterol diet and administered trace levels of copper ion in their drinking water.	Water	184-189	amyloid beta (A4) precursor protein	Mus musculus	60-65
15561418-3	2004	For example, the Na(+)-glutamate cotransporter (EAAT1) has a unit water permeability one tenth of that of aquaporin (AQP) 1.	Water	66-71	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	117-123
27455244-1	2016	Aquaporins (AQPs) are membrane proteins involved in the regulation of cellular transport and the balance of water and glycerol and cell volume in the white adipose tissue (WAT).	Water	108-113	WD and tetratricopeptide repeats 1	Mus musculus	156-163
27351269-6	2016	On account of the requirement of only an MP2-level FC on the entire cluster, the current methodology ultimately leads to a cost-effective solution for the CCSD(T) level accurate binding energies of large-sized water clusters even at the complete basis set limit utilizing off-the-shelf hardware.	Water	210-215	tryptase pseudogene 1	Homo sapiens	41-44
15242101-11	2004	AQP3 in organs other than the kidney may be involved in the supply of water to them.	Water	70-75	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
27447626-4	2016	AQP3 is predominantly expressed in the colon, ultimately controlling the water transport.	Water	73-78	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
14670455-2	2004	The structure, stability and vibrational spectrum of the binary complex between HONO2 and H2O have been investigated using ab initio calculations at SCF and MP2 levels with different basis sets and B3LYP/6-31G(d,p) calculations.	Water	90-93	tryptase pseudogene 1	Homo sapiens	157-160
14671300-3	2003	Here, we present direct measurements of brine rejection and formation of North Pacific Intermediate Water in the Okhotsk Sea from moored winter observations.	Water	100-105	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	121-124
27447626-7	2016	These findings have shown that AQP3 is one of the most important functional molecules in water transport in the colon.	Water	89-94	aquaporin 3 (Gill blood group)	Homo sapiens	31-35
27436489-6	2016	Chemical TRPV4 inhibitors (HC-067047 and Gadolinium) or TRPV4 knockout, but not TRPV1 inhibitor SB-705498, could restore the water intake under hypoxia.	Water	125-130	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	9-14
14588144-2	2003	Treatment of BAEC with 1 mM H(2)O(2) caused increases of DNA fragmentation, p53 expression, Bax/Bcl-2 ratio, and the activities of caspases 3 and 9.	Water	28-33	BCL2 associated X, apoptosis regulator	Bos taurus	92-95
14588144-2	2003	Treatment of BAEC with 1 mM H(2)O(2) caused increases of DNA fragmentation, p53 expression, Bax/Bcl-2 ratio, and the activities of caspases 3 and 9.	Water	28-33	BCL2 apoptosis regulator	Bos taurus	96-101
27436489-6	2016	Chemical TRPV4 inhibitors (HC-067047 and Gadolinium) or TRPV4 knockout, but not TRPV1 inhibitor SB-705498, could restore the water intake under hypoxia.	Water	125-130	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	56-61
14581612-5	2003	trpv4-/- mice drank less water and became more hyperosmolar than did wild-type littermates, a finding that was seen with and without administration of hypertonic saline.	Water	25-30	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	0-5
27122368-4	2016	We found a divergence in E2"s inhibitory effect on intake: activation of ERalpha decreased water intake, whereas activation of ERbeta decreased saline intake.	Water	91-96	estrogen receptor 1	Rattus norvegicus	73-80
27058007-1	2016	Aquaporin 5 (AQP5) is a water channel that regulates water transport, cell migration, and proliferation.	Water	24-29	aquaporin 5	Homo sapiens	0-11
14528321-3	2003	Previously, we reported protection of rodents against EAU by intravenous or/and periocular injection of vIL-10-expressing adenovirus.	Water	54-57	villin 1	Rattus norvegicus	104-107
27058007-1	2016	Aquaporin 5 (AQP5) is a water channel that regulates water transport, cell migration, and proliferation.	Water	24-29	aquaporin 5	Homo sapiens	13-17
27058007-1	2016	Aquaporin 5 (AQP5) is a water channel that regulates water transport, cell migration, and proliferation.	Water	53-58	aquaporin 5	Homo sapiens	0-11
12941561-1	2003	The optical biosensor consisting of a glutathione-S-transferase (GST)-immobilized gel film was developed to detect captan in contaminated water.	Water	138-143	glutathione S-transferase kappa 1	Homo sapiens	38-63
27058007-1	2016	Aquaporin 5 (AQP5) is a water channel that regulates water transport, cell migration, and proliferation.	Water	53-58	aquaporin 5	Homo sapiens	13-17
12941561-1	2003	The optical biosensor consisting of a glutathione-S-transferase (GST)-immobilized gel film was developed to detect captan in contaminated water.	Water	138-143	glutathione S-transferase kappa 1	Homo sapiens	65-68
27191611-2	2016	They are especially involved in potassium (K+) and water homeostasis, via inwardly rectifying K+ (Kir 4.1) and aquaporin-4 (AQP4) channels respectively.	Water	51-56	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	98-105
14516795-4	2003	Elimination of H(2)O(2) by catalase or N-acetyl-L-cysteine inhibited the arsenite-induced activation of p70(s6k) and ERK1/2, indicating the possible role of H(2)O(2) in the arsenite activation of the p70(s6k) and the ERK1/2 signaling pathways.	Water	15-20	ribosomal protein S6 kinase B1	Homo sapiens	104-111
27191611-2	2016	They are especially involved in potassium (K+) and water homeostasis, via inwardly rectifying K+ (Kir 4.1) and aquaporin-4 (AQP4) channels respectively.	Water	51-56	aquaporin 4	Rattus norvegicus	111-122
14516795-4	2003	Elimination of H(2)O(2) by catalase or N-acetyl-L-cysteine inhibited the arsenite-induced activation of p70(s6k) and ERK1/2, indicating the possible role of H(2)O(2) in the arsenite activation of the p70(s6k) and the ERK1/2 signaling pathways.	Water	15-20	ribosomal protein S6 kinase B1	Homo sapiens	200-207
27191611-2	2016	They are especially involved in potassium (K+) and water homeostasis, via inwardly rectifying K+ (Kir 4.1) and aquaporin-4 (AQP4) channels respectively.	Water	51-56	aquaporin 4	Rattus norvegicus	124-128
27023350-2	2016	During dehydration, arginine vasopressin (AVP) stimulates the expression and trafficking of aquaporin 2 (AQP2) to the apical membrane of CD principal cells, thereby allowing water reabsorption from the primary urine.	Water	174-179	aquaporin 2	Mus musculus	92-103
15149973-1	2004	Aquaporin-4 (AQP4) water channels exist as heterotetramers of M1 and M23 splice variants and appear to be present in orthogonal arrays of intramembraneous particles (OAPs) visualized by freeze-fracture microscopy.	Water	19-24	aquaporin 4	Rattus norvegicus	0-11
15149973-1	2004	Aquaporin-4 (AQP4) water channels exist as heterotetramers of M1 and M23 splice variants and appear to be present in orthogonal arrays of intramembraneous particles (OAPs) visualized by freeze-fracture microscopy.	Water	19-24	aquaporin 4	Rattus norvegicus	13-17
15149973-9	2004	We conclude that the higher-order organization of AQP4 in OAPs increases single-channel osmotic water permeability by one order of magnitude and that differential cellular expression levels of the two isoforms could regulate this organization.	Water	96-101	aquaporin 4	Rattus norvegicus	50-54
27023350-2	2016	During dehydration, arginine vasopressin (AVP) stimulates the expression and trafficking of aquaporin 2 (AQP2) to the apical membrane of CD principal cells, thereby allowing water reabsorption from the primary urine.	Water	174-179	aquaporin 2	Mus musculus	105-109
27186970-3	2016	Moreover, DCT-1 also exhibits aggregation-induced emission properties in water with excellent photostability and pH-stability for potential cell imaging applications.	Water	73-78	solute carrier family 36 member 1	Homo sapiens	10-15
15191914-1	2004	The physiological role of the duodenal peptide secretin is as a potent stimulant of electrolyte and water movement in pancreatic and biliary epithelium, via activation of G protein-coupled secretin receptors (hSCTR).	Water	100-105	secretin receptor	Homo sapiens	209-214
15251111-4	2004	One group of CP-treated mice was also given LF in drinking water (0.5% solution) for 14 days.	Water	59-64	lactotransferrin	Mus musculus	44-46
27146428-2	2016	In this letter, we demonstrate a cobalt phosphide nanowire array grown on a Ti mesh (CoP/TM) behaving as a bifunctional electrocatalyst for water splitting.	Water	140-145	caspase recruitment domain family member 16	Homo sapiens	85-88
15046928-1	2004	Poly (n-butyl cyanoacrylate) (PBCA) nanoparticles were prepared by a dispersion polymerisation process in water at pH 3 and using dextran as a stabilising agent.	Water	106-111	PBCA	Homo sapiens	30-34
26610908-1	2016	BACKGROUND: The water channel aquaporin 2 (AQP2) at the apical membrane of renal collecting duct cells mediates water reabsorption.	Water	16-21	aquaporin 2	Homo sapiens	43-47
15219933-5	2004	Two hours after oral water loading, the mean U-AQP2/creatinine ratio decreased significantly from (231 +/- 30) x 10(-9) to (60 +/- 15) x 10(-9) (P = 0.01), while the median plasma VP concentration decreased from 4.2 pmol/l (range 2.2-4.8 pmol/l) to 1.2 pmol/l (range 1.0-1.9 pmol/l).	Water	21-26	aquaporin 2	Canis lupus familiaris	47-51
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	116-121	filaggrin	Homo sapiens	394-403
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	116-121	keratin 10	Homo sapiens	413-422
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	filaggrin	Homo sapiens	394-403
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 10	Homo sapiens	413-422
27178416-4	2016	Interaction energy values of -19.90, -19.66, -14.01, -8.70, and -4.76 kJ mol(-1) were achieved for adsorption of SO3, H2O, NH3, HCN, and H2S on 3PT, respectively.	Water	118-121	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	128-131
27427640-0	2016	Cubic Mesoporous Silica Material as a Highly Efficient Solid Phase Extraction Sorbent for Bisphenol A, Tert-Nonylphenol from Water.	Water	125-130	telomerase reverse transcriptase	Homo sapiens	103-107
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	filaggrin	Homo sapiens	394-403
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 10	Homo sapiens	413-422
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	filaggrin	Homo sapiens	394-403
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 10	Homo sapiens	413-422
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	filaggrin	Homo sapiens	394-403
26993463-8	2016	A key interaction between trimethylated Lys36 and a conserved water molecule stabilized by Ser270 explains the lack of affinity of mutated DNMT3B (S270P) for the H3K36me3 epigenetic mark in the ICF (Immunodeficiency, Centromeric instability and Facial abnormalities) syndrome.	Water	62-67	DNA methyltransferase 3 beta	Homo sapiens	139-145
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 10	Homo sapiens	413-422
15248719-0	2004	Flow-induced molecular segregation in beta-casein-monoglyceride mixed films spread at the air-water interface.	Water	94-99	casein beta	Homo sapiens	38-49
27093467-7	2016	Simulations were conducted on myoglobin in water, water/sulfolane, and water/m-NBA.	Water	43-48	myoglobin	Homo sapiens	30-39
15222753-6	2004	Detailed analysis of the water structure around Gln262 and the active site Cys215 reveals that the probability of finding a water molecule correctly positioned for catalysis is much larger in PTP1B than in PTP1B(R47V,D48N,M258C,G259Q) and PTPalpha, in accordance with experiments.	Water	25-30	protein phosphatase 2 phosphatase activator	Homo sapiens	239-247
15222753-6	2004	Detailed analysis of the water structure around Gln262 and the active site Cys215 reveals that the probability of finding a water molecule correctly positioned for catalysis is much larger in PTP1B than in PTP1B(R47V,D48N,M258C,G259Q) and PTPalpha, in accordance with experiments.	Water	124-129	protein phosphatase 2 phosphatase activator	Homo sapiens	239-247
26951941-4	2016	We showed that the inhibitory effect of E2 on ANGII-induced water and sodium intake requires the ERK1/2 and JNK signaling pathways.	Water	60-65	mitogen-activated protein kinase 8	Rattus norvegicus	108-111
15213263-7	2004	These results suggest that At1a receptor-mediated inputs play critical roles in maintaining renal vascular eNOS expression and activity during changes in salt-water balance and systemic BP.	Water	159-164	nitric oxide synthase 3, endothelial cell	Mus musculus	107-111
27099247-3	2016	OBJECTIVE: In this study we investigated the effect of an intravenous injection of corticotropin-releasing factor (CRF) on fructose malabsorption and the resulting volume of water in the small bowel.	Water	174-179	corticotropin releasing hormone	Homo sapiens	83-113
15856559-0	2004	Water related environment modelling on Mars.	Water	0-5	methionyl-tRNA synthetase 1	Homo sapiens	39-43
15157862-4	2004	The solvent drop (CCl4 is almost water insoluble) is pushed towards the bubble position and forms a thin film on the bubble surface.	Water	33-38	C-C motif chemokine ligand 4	Homo sapiens	18-22
15986678-3	2004	The surface pressure-area (pi-A) isotherm showed that acryloyl-PEG molecules were stable in the phospholipid monolayer and that they could be evenly inserted into a phospholipid monolayer at the air/water interface.	Water	199-204	progestagen associated endometrial protein	Homo sapiens	54-66
21232217-6	2004	CONCLUSIONS: Aquaporin 3 and aquaporin 5 express in SPC-A-1 cell, and their roles in water transport of SPC-A-1 cell should be further investigated.	Water	85-90	aquaporin 3 (Gill blood group)	Homo sapiens	13-24
21232217-6	2004	CONCLUSIONS: Aquaporin 3 and aquaporin 5 express in SPC-A-1 cell, and their roles in water transport of SPC-A-1 cell should be further investigated.	Water	85-90	aquaporin 5	Homo sapiens	29-40
15066905-16	2004	We hypothesize that PK-2-rich projections from SCN neurons to PKR-expressing ARC neurons could transmit the circadian rhythm of feeding, whereas inputs from the PK-2-expressing NTS neurons to the PKR-2-expressing SFO neurons could transmit visceral information on the water-electrolyte balance and osmotic regulation.	Water	268-273	prokineticin 2	Rattus norvegicus	20-24
15115689-10	2004	Likewise, the water soluble extract of Echinacea was able to stimulate non-adherent splenocyte populations to produce TNF-alpha (2082 pg/ml), IL-10 (892 pg/ml) and MIP-1alpha (6486 pg/ml) from non-adherent splenocytes, but only significant concentrations of TNF-alpha and MIP-1alpha mediators were produced from adherent populations at similar dose concentrations.	Water	14-19	chemokine (C-C motif) ligand 3	Mus musculus	164-174
15115689-10	2004	Likewise, the water soluble extract of Echinacea was able to stimulate non-adherent splenocyte populations to produce TNF-alpha (2082 pg/ml), IL-10 (892 pg/ml) and MIP-1alpha (6486 pg/ml) from non-adherent splenocytes, but only significant concentrations of TNF-alpha and MIP-1alpha mediators were produced from adherent populations at similar dose concentrations.	Water	14-19	chemokine (C-C motif) ligand 3	Mus musculus	272-282
15100362-1	2004	A Mexican family with partial congenital nephrogenic diabetes insipidus (NDI) that resulted from a mutation in the aquaporin-2 water channel (AQP2) was characterized, and the source of this rare mutation was traced to the family"s town of origin in Mexico.	Water	127-132	aquaporin 2	Homo sapiens	115-126
15100362-1	2004	A Mexican family with partial congenital nephrogenic diabetes insipidus (NDI) that resulted from a mutation in the aquaporin-2 water channel (AQP2) was characterized, and the source of this rare mutation was traced to the family"s town of origin in Mexico.	Water	127-132	aquaporin 2	Homo sapiens	142-146
17200614-9	2004	Our results strongly suggest that the IFN-inducible RNase L is induced by a broad range of stress-inducing signals such as double-stranded RNA (dsRNA) produced during viral infection, membrane- and osmotic shock caused by CaCl(2) and oxidative stress induced by H(2)O(2), inflammation stimulated by TNF-alpha and chemotherapy.	Water	262-268	ribonuclease L	Homo sapiens	52-59
15079033-3	2004	If the CSF opening pressure is higher than 20 cm water, an increase of 5 cm water CSF pressure corresponds to a papilla volume increase of 0.95 mm3 as well as a papilla height increase of 0.34 mm.	Water	49-54	colony stimulating factor 2	Homo sapiens	7-10
15079033-3	2004	If the CSF opening pressure is higher than 20 cm water, an increase of 5 cm water CSF pressure corresponds to a papilla volume increase of 0.95 mm3 as well as a papilla height increase of 0.34 mm.	Water	49-54	colony stimulating factor 2	Homo sapiens	82-85
15079033-3	2004	If the CSF opening pressure is higher than 20 cm water, an increase of 5 cm water CSF pressure corresponds to a papilla volume increase of 0.95 mm3 as well as a papilla height increase of 0.34 mm.	Water	76-81	colony stimulating factor 2	Homo sapiens	7-10
15079033-3	2004	If the CSF opening pressure is higher than 20 cm water, an increase of 5 cm water CSF pressure corresponds to a papilla volume increase of 0.95 mm3 as well as a papilla height increase of 0.34 mm.	Water	76-81	colony stimulating factor 2	Homo sapiens	82-85
15056956-8	2004	To evaluate Esc-amino acids, Leu-enkephalin amide was synthesized using Esc-amino acids by the solid phase method in water.	Water	117-122	prodynorphin	Homo sapiens	29-43
15056956-15	2004	The yields of synthesis of Leu-enkephalin amide in water and dimethylformamide were 71% and 67%, respectively.	Water	51-56	prodynorphin	Homo sapiens	27-41
14715716-3	2004	In this study we used restraint stress in water to elucidate the mechanism by which PRLR in the rat brain mediate the protective effect of PRL against stress-induced hypocalcemia and ulcerogenesis.	Water	42-47	prolactin receptor	Rattus norvegicus	84-88
14715716-5	2004	This is followed by an increase in the long form of PRLR mRNA expression in the choroid plexus of the brain, which provides protection against restraint stress in water-induced hypocalcemia and gastric erosions.	Water	163-168	prolactin receptor	Rattus norvegicus	52-56
15267480-1	2004	Tunneling splittings in the water dimer have been determined by the semiclassical WKB method, based on pathways characterized at the computational level of second-order Moller-Plesset (MP2) theory with basis sets of aug-cc-pVTZ quality.	Water	28-33	tryptase pseudogene 1	Homo sapiens	185-188
15016894-4	2004	In the CD4-bound conformation of gp120, the amino acid residues implicated in BMS-806 and #155 resistance line the "phenylalanine 43 cavity" and a water-filled channel that extends from this cavity to the inner domain.	Water	147-152	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	33-38
15835162-2	2004	Raman spectra of collective OH stretching vibration of water molecules in aqueous solutions of maltose-pRX conjugates with different alpha-cyclodextrin (alpha-CD) threading on a poly(ethylene glycol) (PEG) chain was measured.	Water	55-60	periaxin	Homo sapiens	103-106
15835162-6	2004	It is suggested that rapid motion of maltose groups in the pRX conjugate can contribute to preserving ordered structure of the bulk water clusters.	Water	132-137	periaxin	Homo sapiens	59-62
15252503-1	2004	The reaction of [ClP(mu-NtBu)]2 (1) with H2O (1 : 2 equivalents) in the presence of excess Et3N gives the new chain compound [(mu-O)[P(mu-NtBu)2P(H)=O]2] (3), consisting of two P2N2 rings linked by a mu-O atom and terminating in P(V)(H)=O groups.	Water	41-44	calmodulin like 3	Homo sapiens	17-20
15036401-6	2004	Additional assays revealed that the levels of alpha(2)M increased in irreversible growth arrest induced by sublethal H(2)O(2), but not in quiescent state of cultured fibroblasts induced by serum-deprivation, and remained stable in Hela cells.	Water	117-122	alpha-2-macroglobulin	Homo sapiens	46-55
15202235-3	2004	Four situ investigations were made in the coastal water of Qingdao, which is located at west coast of Yellow Sea.	Water	50-55	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
14978251-2	2004	Upon sulfonation, SULT2A1 substrates become polar and water-soluble and thus suitable for rapid excretion.	Water	54-59	sulfotransferase family 2A member 1	Rattus norvegicus	18-25
14660661-8	2004	Extensive oligomerization of the decorin protein core was observed only after dialysis against water and freeze-drying.	Water	95-100	decorin	Homo sapiens	33-40
14645499-1	2004	The human secretin receptor (hSR) is an important glycoprotein receptor for regulating the secretion of pancreatic bicarbonate, water, and electrolytes.	Water	128-133	secretin receptor	Homo sapiens	10-27
14759059-1	2004	A newly designed jet-type, water-cooled heat sink (the funryu heat sink, meaning fountain flow in Japanese) yielded 255-W cw laser output at 808 nm from a 1-cm bar made from InGaAsP/InGaP quantum-well active layers with a 67% fill factor [70 quantum-well laser diode (LD) array along the 1-cm bar].	Water	27-32	regenerating family member 3 alpha	Homo sapiens	182-187
15743078-4	2004	Furthermore, we have demonstrated for the first time using in situ SFG measurement that the interfacial molecular structure at the LB bilayer of stearic acid on the hydrophilic substrates significantly change with immersion in the water subphase containing Cd2+ cation while such a structural change has not been observed in the water subphase without Cd2+.	Water	231-236	CD2 molecule	Homo sapiens	257-260
15743078-4	2004	Furthermore, we have demonstrated for the first time using in situ SFG measurement that the interfacial molecular structure at the LB bilayer of stearic acid on the hydrophilic substrates significantly change with immersion in the water subphase containing Cd2+ cation while such a structural change has not been observed in the water subphase without Cd2+.	Water	231-236	CD2 molecule	Homo sapiens	352-355
15743078-4	2004	Furthermore, we have demonstrated for the first time using in situ SFG measurement that the interfacial molecular structure at the LB bilayer of stearic acid on the hydrophilic substrates significantly change with immersion in the water subphase containing Cd2+ cation while such a structural change has not been observed in the water subphase without Cd2+.	Water	329-334	CD2 molecule	Homo sapiens	257-260
14695256-6	2004	We found that, for equivalent cation or glucose uptakes, the combination of substrate accumulations observed with ROMK2 and GLUT2 are sufficient to provide the osmotic gradient necessary to account for a passive water flux through SGLT1.	Water	212-217	solute carrier family 2 member 2 S homeolog	Xenopus laevis	124-129
14575744-5	2004	In particular, results from batch and column experiments show that ABS based on these materials can efficiently demobilise iron and manganese from percolating, anoxic pore water by cation exchange under favourable conditions.	Water	172-177	DEAD-box helicase 41	Homo sapiens	67-70
14964369-9	2004	Although still preliminary, in the absence of longer monitoring, this study shows that MT-2A gene expression is a useful tool to complement chemical analysis in assessing metal elements in water.	Water	189-194	metallothionein 2A	Homo sapiens	87-92
15318303-3	2004	In this paper, an effort to label DPD and EHIDA with [99mTc(CO)3(H2O)3]+ was carried out.	Water	65-68	dihydropyrimidine dehydrogenase	Rattus norvegicus	34-37
15318303-11	2004	DISCUSSION: The results of the labelling of DPD and EHIDA with [99mTc(CO)3(H2O)3]+ and their chemical and biological behaviour, in comparison with the same one for 99mTc-DPD and 99mTc-EHIDA, confirmed that different oxidation states of technetium make the formation of a variety of complexes with quite different behaviour possible.	Water	75-78	dihydropyrimidine dehydrogenase	Rattus norvegicus	44-47
14705028-6	2004	Finally, the Hao-containing peptide, Ac-Ala-Hao-Ala-NHMe, is shown to form a stable complex with the Ras analogue, Rap1 A, in water at room temperature.	Water	126-131	RAP1A, member of RAS oncogene family	Homo sapiens	115-121
12835947-9	2003	In a "pick-up test" all patients were able to pick up a pencil, they were able to write and could hold a full cup of water.	Water	117-122	protein interacting with PRKCA 1	Homo sapiens	6-10
14714748-1	2003	The aim of this study was to determine whether infrared thermography before and after challenge of the lower leg in cold water may be a useful tool to detect abnormalities in skin blood flow in adolescent asymptomatic patients with type 1 diabetes mellitus (DM1) and to assess the optimal setting of skin temperature measurements.	Water	121-126	immunoglobulin heavy diversity 1-7	Homo sapiens	258-261
14714748-7	2003	Infrared thermography of the lower leg after cold water exposure is an easily applicable method and a useful tool to detect abnormalities of skin blood flow in adolescents with DM1 especially at the tips of the first and fifth toes and the inner ankle.	Water	50-55	immunoglobulin heavy diversity 1-7	Homo sapiens	177-180
14643780-2	2003	The development of severe eutrophication imposed the three main activity adoption focuses on (1) macroalgae harvesting; (2) pumping of water from the sea; (3) confining wastewater to phytotreatment ponds.	Water	135-140	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	150-153
14605277-9	2003	CONCLUSIONS: The expression of the collecting duct water channel AQP2, p-AQP2 and AQP3 was significantly downregulated after HS, which may play an important role in the impaired urinary concentrating ability in HS-induced acute renal failure.	Water	51-56	aquaporin 2	Rattus norvegicus	65-69
12876065-11	2003	In response to 36-h water deprivation, inner medulla AQP-2 protein abundance was decreased in POLY rats compared with CTL rats (65 +/- 5 vs. 100 +/- 5% CTL mean, P &lt; 0.0006).	Water	20-25	aquaporin 2	Rattus norvegicus	53-58
12951005-2	2003	It was found that both polyhydroxyalkanoates (PHA) subjected to lipase treatment and hyaluronan (HA) coating decreased the contact angle of water to the material surface approximately 30%, meaning an increased hydrophilicity on the PHA surface.	Water	140-145	lipase, endothelial	Mus musculus	64-70
14714518-1	2003	It was shown using the Ellman"s reagent that chloride and bicarbonate anions are the heat-induced reducing agents of sea-water, and their combined action is more than additive.	Water	121-126	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	117-120
14714518-3	2003	The influence of sea-water anions on the heat-induced production of hydrogen peroxide was studied by enhanced chemiluminescence in a peroxidase-luminol-p-iodophenol system.	Water	21-26	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	17-20
14714518-4	2003	In NaCl and NaHCO3 solutions, at concentration and pH values equal to those of sea-water, the production of H2O2 upon heating increased, as compared with water, whereas sulfate anions depressed its formation.	Water	83-88	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	79-82
12961084-4	2003	In the adult proximal tubule, this is accomplished by the expression of aquaporin 1 (AQP1), the water channel located on the apical and basolateral membranes of the proximal tubule.	Water	96-101	aquaporin-1	Oryctolagus cuniculus	72-83
12961084-4	2003	In the adult proximal tubule, this is accomplished by the expression of aquaporin 1 (AQP1), the water channel located on the apical and basolateral membranes of the proximal tubule.	Water	96-101	aquaporin-1	Oryctolagus cuniculus	85-89
13679067-5	2003	We further demonstrated that H(2)O(2) stimulates PAI-1 expression and suppresses plasmin activity and that N-acetylcysteine effectively reverses TGF-beta1- and H(2)O(2)-induced changes in PAI-1 expression and plasmin activity.	Water	29-34	serpin family E member 1	Homo sapiens	49-54
12783779-3	2003	In the present study, a continuous infusion of synthetic human UII (hUII) into the renal artery (RA) in anesthetized rats was found to increase renal blood flow (RBF) and urinary water and sodium excretion (UV and UNaV) in a dose-dependent manner.	Water	179-184	urotensin 2	Homo sapiens	63-66
12783779-3	2003	In the present study, a continuous infusion of synthetic human UII (hUII) into the renal artery (RA) in anesthetized rats was found to increase renal blood flow (RBF) and urinary water and sodium excretion (UV and UNaV) in a dose-dependent manner.	Water	179-184	urotensin 2	Homo sapiens	68-72
12783779-7	2003	Nitric oxide (NO) synthase inhibitor NG-nitro-l-arginine methyl ester (l-NAME) completely abolished hUII-induced increases in RBF and water/sodium excretion.	Water	134-139	urotensin 2	Homo sapiens	100-104
14616086-6	2003	The water binding properties of bovine lens alpha-crystallin, calf skin collagen, and bovine serum albumin (BSA) were investigated with various techniques.	Water	4-9	albumin	Bos taurus	93-106
12819228-11	2003	Although the active site residues differ between nm-HO and human HO-1, the close similarity in the H-bonded water network suggests a common mechanism shared by all heme oxygenases.	Water	108-113	heme oxygenase 1	Homo sapiens	65-69
12821661-1	2003	A second group of proteorhodopsin-encoding genes (blue-absorbing proteorhodopsin, BPR) differing by 20-30% in predicted primary structure from the first-discovered green-absorbing (GPR) group has been detected in picoplankton from Hawaiian deep sea water.	Water	249-254	DBH antisense RNA 1	Homo sapiens	82-85
12956944-4	2003	RESULTS: Ethanol given to rats in drinking water decreased the level of p-CREB protein in the nucleus accumbens (-75 %) at the time of exposure to ethanol.	Water	43-48	cAMP responsive element binding protein 1	Rattus norvegicus	74-78
15326914-9	2003	We suggest that the introduction of a hydroxy group at position 3 relative to a tertiary ammonium charged center, or the introduction of hydroxy, alkoxy or amino groups at position 2 relative to the nitrogen center of an aromatic system, should provide easy access of a water molecule to the proton, thereby facilitating deprotonation and thus leading to a moderate or weak HERG/I(Kr) blockade and a reduced risk of TdP.	Water	270-275	potassium voltage-gated channel subfamily H member 2	Homo sapiens	374-378
12819302-2	2003	Aquaporins (AQP) 1, 3, 4 and 5 are membranous water channel proteins that are present in the lung after birth in rodents, with little expression before birth.	Water	46-51	aquaporin-1	Ovis aries	0-30
12930978-9	2003	These results indicate that the analysis of intracellular NAD(P)H level using water-soluble tetrazolium salt can assess an imbalance of SSB repair in living cells in real time.	Water	78-83	lupus La protein	Cricetulus griseus	136-139
12970474-4	2003	Cytosolic G6PDH activity remained constant during water incubation in the dark.	Water	50-55	glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform	Solanum tuberosum	10-15
12970474-9	2003	Plastidic G6PDH activity stayed constant during water incubation in the light and dropped to minimal levels within 6 h in the dark.	Water	48-53	glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform	Solanum tuberosum	10-15
12970474-13	2003	K(m) (Glc-6-phosphate) values of plastidic G6PDH activity differed between samples incubated on water or Paraquat, suggesting posttranslational modification of the plastidic enzyme(s).	Water	96-101	glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform	Solanum tuberosum	43-48
12911303-0	2003	Structural changes of water molecules during the photoactivation processes in bovine rhodopsin.	Water	22-27	rhodopsin	Bos taurus	85-94
12924577-4	2003	In turn, KOC values have been estimated by quantitative structure-activity relationships (QSARs) developed by correlation with a variety of physical or chemical properties and structural descriptors related to the hydrophobicity of the chemical such as octanol-water partition coefficients, aqueous solubilities, molecularconnectivity indices, molecular weight, molecular surface area, and reverse-phase high-performance liquid chromatography retention times.	Water	261-266	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	9-12
12865281-11	2003	Moreover, urinary AQP2 excretion increased with severity of cirrhosis in parallel with impairment of free water clearance.	Water	106-111	aquaporin 2	Homo sapiens	18-22
12865281-12	2003	This suggests a functional association between increased AQP2 excretion and increased renal reabsorption of water in cirrhosis.	Water	108-113	aquaporin 2	Homo sapiens	57-61
12811453-1	2003	Bond Elut C(18) solid-phase extraction cartridges were used for pre-concentration followed by derivatization with o-phthaldialdehyde-N-acetylcysteine (OPA-NAC) of primary amines in water.	Water	181-186	synuclein alpha	Homo sapiens	155-158
12812975-8	2003	In the probe trial of the Morris Water Maze test, Chl1(-/-) mice displayed an altered exploratory pattern.	Water	33-38	cell adhesion molecule L1-like	Mus musculus	50-54
12861054-1	2003	Peroxiredoxin-3 (Prdx3) is a mitochondrial member of the antioxidant family of thioredoxin peroxidases that uses mitochondrial thioredoxin-2 (Trx2) as a source of reducing equivalents to scavenge hydrogen peroxide (H(2)O(2)).	Water	215-220	peroxiredoxin 3	Mus musculus	0-15
12861054-1	2003	Peroxiredoxin-3 (Prdx3) is a mitochondrial member of the antioxidant family of thioredoxin peroxidases that uses mitochondrial thioredoxin-2 (Trx2) as a source of reducing equivalents to scavenge hydrogen peroxide (H(2)O(2)).	Water	215-220	peroxiredoxin 3	Mus musculus	17-22
12861054-1	2003	Peroxiredoxin-3 (Prdx3) is a mitochondrial member of the antioxidant family of thioredoxin peroxidases that uses mitochondrial thioredoxin-2 (Trx2) as a source of reducing equivalents to scavenge hydrogen peroxide (H(2)O(2)).	Water	215-220	thioredoxin 2	Mus musculus	142-146
12861054-6	2003	Thus, mitochondrial Prdx3 is an important cellular antioxidant that regulates physiological levels of H(2)O(2), leading to decreased cell growth while protecting cells from the apoptosis-inducing effects of high levels of H(2)O(2).	Water	102-107	peroxiredoxin 3	Mus musculus	20-25
12861054-6	2003	Thus, mitochondrial Prdx3 is an important cellular antioxidant that regulates physiological levels of H(2)O(2), leading to decreased cell growth while protecting cells from the apoptosis-inducing effects of high levels of H(2)O(2).	Water	222-227	peroxiredoxin 3	Mus musculus	20-25
12869794-4	2003	We examined expression of Ucn II mRNA in the PVN and LC following immobilization stress, water deprivation, and adrenalectomy.	Water	89-94	urocortin 2	Rattus norvegicus	26-32
12869794-6	2003	In contrast, water deprivation for 3 days induced Ucn II mRNA expression mainly in the magnocellular part of the PVN.	Water	13-18	urocortin 2	Rattus norvegicus	50-56
12869794-9	2003	Double-label in situ hybridization revealed colocalization of Ucn II mRNA in approximately 45% of the CRH mRNA-expressing cells in the parvocellular part of the PVN following immobilization, or colocalization in most of the vasopressin mRNA-expressing cells in the magnocellular part of the PVN following water deprivation.	Water	305-310	urocortin 2	Rattus norvegicus	62-68
12881590-2	2003	In peripheral epithelial tissues, sodium and water transport is regulated by corticosteroids and the 11beta-hydroxysteroid dehydrogenase (11beta-HSD) isozymes (11beta-HSD1 activating cortisol from cortisone, 11beta-HSD2 inactivating cortisol to cortisone).	Water	45-50	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	208-219
14587334-4	2003	Based on the Redfield ratio (Si:N:P = 16:16:1) in which, three essential nutrients were utilized by marine phytoplankton, the Si/N/P ratios were calculated and studied for the upper water of the Yellow Sea and the East China Sea.	Water	182-187	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	202-205
12787682-7	2003	At this pH, most significant are the alteration of the arrangement of salt bridges and of the network of water molecules/H-bonds that participates in the retinol-RBP interaction, an appreciable increase of the volume of the beta-barrel cavity, a considerably higher degree of mobility of the RBP-bound ligand and of several protein regions and the disorder of a large number of solvent molecules that are ordered at neutral pH.	Water	105-110	retinol binding protein 4	Bos taurus	162-165
12783541-2	2003	Using a combined QM/MM Monte Carlo/free-energy perturbation (MC/FEP) method, 82% and 100% of chorismate conformers were found to be NAC structures in water and in the CM active site, respectively.	Water	150-155	synuclein alpha	Homo sapiens	132-135
18969077-5	2003	It can induce both lipophilic alpha-bromonaphthalene or 1-bromo-2-methylnaphthalene (BrMeN) and strongly water-soluble meso-tetrakis-(4-trimethylaminophenyl)porphyrin palladium (Pd-TAPP) to produce strong RTP emission under sodium deoxycholate of 4 mmol l(-1) and incubation time of half an hour.	Water	105-110	MORN repeat containing 4	Homo sapiens	205-208
27194950-10	2016	The results of the present study indicated that the kidneys of the examined euryhaline medakas originating from brackish water and fresh water exhibited different modulatory mechanisms through which renal FXYD12 enhanced NKA activity to maintain internal homeostasis.	Water	121-126	FXYD domain-containing ion transport regulator 12	Oryzias latipes	205-211
14503402-3	2003	The hydrophilic surface of the CNT-Triton conjugate interacts with the hydrophilic surface of BVRB, thus creating a water-soluble complex.	Water	116-121	biliverdin reductase B	Homo sapiens	94-98
27194950-10	2016	The results of the present study indicated that the kidneys of the examined euryhaline medakas originating from brackish water and fresh water exhibited different modulatory mechanisms through which renal FXYD12 enhanced NKA activity to maintain internal homeostasis.	Water	137-142	FXYD domain-containing ion transport regulator 12	Oryzias latipes	205-211
12733932-10	2003	In a CH(3)OH:H(2)O mixture the phase-transition properties alter and only the five-coordinated form is detected for Cob(II)ester and for base-off B(12r) at all temperatures.	Water	13-18	metabolism of cobalamin associated B	Homo sapiens	116-119
32263281-1	2016	Ionic cross-linking of water-soluble chitosan with sodium tripolyphosphate in the presence of recombinant tissue plasminogen activator (rtPA) and magnetite (Fe3O4) nanoparticles could produce rtPA-encapsulated magnetic chitosan nanoparticles (MCNPs-rtPA).	Water	23-28	plasminogen activator, tissue type	Rattus norvegicus	106-134
12676734-1	2003	This review outlines recent advances related to the molecular mechanisms and pathways of aquaporin-2 (AQP2) water channel trafficking.	Water	108-113	aquaporin 2	Homo sapiens	89-100
12676734-1	2003	This review outlines recent advances related to the molecular mechanisms and pathways of aquaporin-2 (AQP2) water channel trafficking.	Water	108-113	aquaporin 2	Homo sapiens	102-106
27081066-1	2016	We report the quantitative assessment of nuclear quantum effects on the strength of a single hydrogen bond formed at a water-salt interface, using tip-enhanced inelastic electron tunneling spectroscopy based on a scanning tunneling microscope.	Water	119-124	TOR signaling pathway regulator	Homo sapiens	147-150
27081066-2	2016	The inelastic scattering cross section was resonantly enhanced by "gating" the frontier orbitals of water via a chlorine-terminated tip, so the hydrogen-bonding strength can be determined with high accuracy from the red shift in the oxygen-hydrogen stretching frequency of water.	Water	100-105	TOR signaling pathway regulator	Homo sapiens	132-135
26878108-2	2016	Using first-principles calculations, we show that strain is also effective for tuning the catalytic activity of m-MS2 (M = Mo or Nb) towards the hydrogen evolution reaction (HER), which is essential for electrochemical hydrogen generation from water splitting.	Water	244-249	MS2	Homo sapiens	114-117
12707024-1	2003	In this study, we examined the unique relationship of maspin, a serine protease inhibitor (serpin), that plays a critical role in mammary gland development and is silenced during breast cancer progression, and nitric oxide (NO), a multifaceted water and lipid soluble free radical.	Water	244-249	serpin family B member 5	Homo sapiens	54-60
26974355-0	2016	Synthesis of water soluble glycosides of pentacyclic dihydroxytriterpene carboxylic acids as inhibitors of alpha-glucosidase.	Water	13-18	sucrase-isomaltase	Homo sapiens	107-124
12826798-6	2003	If BMP/NCP was treated to remove a 22-kd protein, it became water-soluble and exhibited a similar activity pattern to rhBMP-4.	Water	60-65	bone morphogenetic protein 1	Homo sapiens	3-6
26974355-3	2016	The solubility and inhibitory activity of alpha-glucosidase assays showed that the bis-disaccharide glycosides of triterpene acids possessed higher water solubility and alpha-glucosidase inhibitory activities than the bis-monosaccharide glycosides.	Water	148-153	sucrase-isomaltase	Homo sapiens	42-59
12762993-3	2003	Proton residual dipolar couplings determined from the DQ build-up curves in the initial excitation/reconversion time regime which mainly represent the bound water are interpreted in terms of a model of spin-1/2 pairs with their internuclear axes oriented on average along the fibril direction in the presence of proton exchange.	Water	157-162	spindlin-1	Ovis aries	202-208
26980711-6	2016	Mice microinfused with Abeta1-42 into bilateral CA1 subregions displayed learning and memory impairment, as evidenced by reduced memory acquisition and retrieval in the water maze and retention in the passive avoidance tasks; it was also significant that neuroinflammatory and pro-apoptotic factors were increased in Abeta1-42-treated mice.	Water	169-174	carbonic anhydrase 1	Mus musculus	48-51
12803085-2	2003	The water content was varied by using different values of omega 0 (omega 0 = [H2O]/[S]) at fixed AOT (0.1 M) and Trx-100 (0.2 M) concentrations.	Water	4-9	thioredoxin	Homo sapiens	113-116
12803085-6	2003	In both cases, data obtained allowed the microviscosity of the aqueous interior at different omega 0 to be extrapolated and indicate an increase in eta w values with water content, reflecting changes in the shape of Trx-100 microemulsions, which occur at omega 0 = 8.	Water	166-171	thioredoxin	Homo sapiens	216-219
26826300-5	2016	The energy-relayed nanointegration of AIE polymer and peroxalate in water showed a 50-times boosted sensing signal compared to their dissolved mixture in THF.	Water	68-73	thin fur	Mus musculus	154-157
12688721-2	2003	High enantioselectivity (E &gt; 200) was observed when the Lipolase (lipase B from Candida antarctica)-catalyzed reactions were performed with H(2)O (1 equiv) in diisopropyl ether at 60 degrees C. The resolved products, obtained in good chemical yield (36-47%), could be easily separated.	Water	143-148	PAN0_003d1715	Moesziomyces antarcticus	69-75
12818227-7	2003	This pathogenic trick is accomplished by HbC inducing, by mechanisms not fully understood, an increase in the activity of K:Cl cotransport that induces the lost of K(+) and consequently of intracellular water.	Water	203-208	keratin 88, pseudogene	Homo sapiens	41-44
26867578-9	2016	A comparison with the PIG-L deacetylases led to a proposed mechanism for GalB wherein Glu-48 positions and activates the metal-ligated water for the hydration reaction and His-164 acts as a catalytic acid.	Water	135-140	phosphatidylinositol glycan anchor biosynthesis class L	Sus scrofa	22-27
12967097-10	2003	These results show the important role that the diurnal sea breeze exerts on the environmental fate of pollutants such as PAHs in coastal environments as a modulator of air-water exchange and as a potential driver of transport of pollutants between adjacent coastal and terrestrial environments.	Water	172-177	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	55-58
12685706-2	2003	A biphasic pattern was observed in the relationship between the log of the carbon-normalized sorption distribution coefficient (Koc) and the volumetric fraction of water-miscible cosolvent (fc), in this case methanol, that was accounted for with phenanthrene solubility data.	Water	164-169	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	128-131
12685707-1	2003	An improvement of a method for determination of the distribution coefficient for polycyclic aromatic compounds (PAC) between organic carbon and water (Koc) by high-performance liquid chromatography (HPLC) is presented in this paper.	Water	144-149	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	151-154
26645545-6	2016	Acetone and diethylether followed by water induced persistent upregulation of Tlr4 mRNA and increased TLR4 expression in GFAP-expressing astrocytes in spinal cord dorsal horn.	Water	37-42	glial fibrillary acidic protein	Mus musculus	121-125
12797421-8	2003	The water content of membranes prepared at 20 degrees C was higher with Alg/Ela/PEG (61.6 +/- 4.8%), compared to Alg/Ela (49.9 +/- 0.3%).	Water	4-9	apelin receptor early endogenous ligand	Homo sapiens	76-83
26455768-10	2016	Oscillations range from 10-30 mm H2O with a patient who reached 50 mm H2O and 1 who reached 60 mm H2O.	Water	33-36	H1.5 linker histone, cluster member	Homo sapiens	70-79
12553814-1	2003	This communication reports the SERS observation of p-benzosemiquinone radical anion, produced on reduction of p-benzoquinone by Ag nanoparticles at the metal-water interface.	Water	158-163	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	31-35
12928379-4	2003	We find that the effects of H2-O are more complex than previously appreciated; thus, while only minor influences on Ag presentation could be detected after fluid phase uptake, many epitopes were substantially affected after mIg-mediated uptake.	Water	28-32	chemokine (C-X-C motif) ligand 9	Mus musculus	224-227
12928379-7	2003	This finding suggests that H2-O may control the repertoire of peptides presented by B cells depending on the mIg-Ag interaction.	Water	27-31	chemokine (C-X-C motif) ligand 9	Mus musculus	109-112
27023502-0	2016	From Nanorods to Nanowires of CdS Synthesized by a Solvothermal Method: Influence of the Morphology on the Photoactivity for Hydrogen Evolution from Water.	Water	149-154	CDP-diacylglycerol synthase 1	Homo sapiens	30-33
12942371-1	2003	The RNA F-specific coliphages, MS2 and Qbeta, have been used as virus indicators in water and wastewater studies.	Water	84-89	MS2	Homo sapiens	31-34
12773542-0	2003	Nickel and extracellular acidification inhibit the water permeability of human aquaporin-3 in lung epithelial cells.	Water	51-56	aquaporin 3 (Gill blood group)	Homo sapiens	79-90
12773542-4	2003	Incubation with NiCl2 rapidly, dose-dependently, and reversibly decreased water permeability in AQP3-expressing cells.	Water	74-79	aquaporin 3 (Gill blood group)	Homo sapiens	96-100
12773542-12	2003	In addition, the aromatic side chain of His154 was shown to be important for the water permeability of AQP3.	Water	81-86	aquaporin 3 (Gill blood group)	Homo sapiens	103-107
12557891-6	2003	AgRP (7 micro g i3vt), on the other hand, increased water intake but only in proportion to food intake during the dark and the light, and water intake was not increased after i3vt AgRP in the absence of food.	Water	52-57	agouti related neuropeptide	Rattus norvegicus	0-4
12535611-0	2003	Water plays a different role on activation thermodynamic parameters of alcoholysis reaction catalyzed by lipase in gaseous and organic media.	Water	0-5	PAN0_003d1715	Moesziomyces antarcticus	105-111
12535611-1	2003	The effect of water on the alcoholysis of methyl propionate and n-propanol catalyzed by immobilized Candida antarctica lipase B (CALB) has been compared in a continuous solid-gas reactor and in an organic liquid medium.	Water	14-19	PAN0_003d1715	Moesziomyces antarcticus	119-125
27023502-2	2016	The temperature and water/thiourea ratio used in the synthesis determine the surface area, shape, length and degree of crystallinity of the CdS nanostructures obtained.	Water	20-25	CDP-diacylglycerol synthase 1	Homo sapiens	140-143
12374804-0	2003	Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells.	Water	57-62	aquaporin 2	Canis lupus familiaris	45-56
12914699-4	2003	Two essential and invariant acidic residues in a TFIIS loop complement the Pol II active site and could position a metal ion and a water molecule for hydrolytic RNA cleavage.	Water	131-136	transcription elongation factor A3	Homo sapiens	49-54
27023502-4	2016	Nevertheless an increase in the water/thiourea ratio used during the solvothermal synthesis resulted in CdS nanorods with higher crystallinity, lower aspect ratio and lower specific surface area.	Water	32-37	CDP-diacylglycerol synthase 1	Homo sapiens	104-107
12374804-1	2003	In renal collecting ducts, vasopressin increases the expression of and redistributes aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane, leading to urine concentration.	Water	104-109	aquaporin 2	Canis lupus familiaris	85-96
12374804-1	2003	In renal collecting ducts, vasopressin increases the expression of and redistributes aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane, leading to urine concentration.	Water	104-109	aquaporin 2	Canis lupus familiaris	98-102
27136866-0	2016	Experimental evaluation of theoretical sea surface reflectance factors relevant to above-water radiometry.	Water	89-94	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	39-42
12876340-10	2003	This in turn suggests that in the hydrated structures the well ordered water structure in the central core is involved in stabilizing the B13 side-chain conformations and modulating charge repulsions among the six B13 glutamates if they are not protonated, or that, as is considered more likely, the water structure plays an important role in modulating the pK(a) values of the B13 glutamates, resulting in protonation and hydrogen-bond formation.	Water	71-76	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	138-141
12876340-10	2003	This in turn suggests that in the hydrated structures the well ordered water structure in the central core is involved in stabilizing the B13 side-chain conformations and modulating charge repulsions among the six B13 glutamates if they are not protonated, or that, as is considered more likely, the water structure plays an important role in modulating the pK(a) values of the B13 glutamates, resulting in protonation and hydrogen-bond formation.	Water	71-76	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	214-217
12876340-10	2003	This in turn suggests that in the hydrated structures the well ordered water structure in the central core is involved in stabilizing the B13 side-chain conformations and modulating charge repulsions among the six B13 glutamates if they are not protonated, or that, as is considered more likely, the water structure plays an important role in modulating the pK(a) values of the B13 glutamates, resulting in protonation and hydrogen-bond formation.	Water	71-76	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	214-217
12876340-10	2003	This in turn suggests that in the hydrated structures the well ordered water structure in the central core is involved in stabilizing the B13 side-chain conformations and modulating charge repulsions among the six B13 glutamates if they are not protonated, or that, as is considered more likely, the water structure plays an important role in modulating the pK(a) values of the B13 glutamates, resulting in protonation and hydrogen-bond formation.	Water	300-305	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	138-141
12507761-0	2003	Expression of aquaporin 1 and aquaporin 4 water channels in rat choroid plexus.	Water	42-47	aquaporin 4	Rattus norvegicus	30-41
27136866-1	2016	Determination of the water-leaving radiance L&lt;sub&gt;W&lt;/sub&gt; through above-water radiometry requires knowledge of accurate reflectance factors rho of the sea surface.	Water	21-26	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	163-166
14753438-6	2003	VEGF expression as demonstrated immunohistochemically appeared to coincide with vasogenic edema, diagnosed as high intensity areas on apparent diffusion coefficient of water (ADCw) maps.	Water	168-173	vascular endothelial growth factor A	Rattus norvegicus	0-4
14753448-0	2003	Modulation of aquaporin-4 water transport in a model of TBI.	Water	26-31	aquaporin 4	Rattus norvegicus	14-25
14753448-2	2003	The aim of this study was to investigate if astrocytic endfeet are involved in this passage, using a potent activator of Protein Kinase C (phorbol ester) to modify and closing the Aquaporin 4 (AQP4), a water channel specific for astrocytic endfoot.	Water	202-207	aquaporin 4	Rattus norvegicus	180-191
14753448-2	2003	The aim of this study was to investigate if astrocytic endfeet are involved in this passage, using a potent activator of Protein Kinase C (phorbol ester) to modify and closing the Aquaporin 4 (AQP4), a water channel specific for astrocytic endfoot.	Water	202-207	aquaporin 4	Rattus norvegicus	193-197
12878528-5	2003	The anticandidal activity of LF was evident on administration either in drinking water or by intragastric intubation with a stomach tube.	Water	81-86	lactotransferrin	Mus musculus	29-31
12966985-4	2003	In column studies conducted at field capacity, high levels of 2,4-DNT biodegradation were rapidly stimulated by the addition of a complete mineral medium but not by bicarbonate-buffered distilled deionized water or by phosphate-amended tap water.	Water	240-245	5', 3'-nucleotidase, cytosolic	Homo sapiens	66-69
14753448-6	2003	Results of these experiments showed a significant decrease in water content in injured phorbol treated animals, underlying that AQP4 regulation plays an important role in brain edema following stroke, and supporting the concept of cellular formation for edema via astrocytic foot processes.	Water	62-67	aquaporin 4	Rattus norvegicus	128-132
27136866-5	2016	Results from the analysis of radiance measurements from the sea performed with 40 degrees viewing angle and 90 degrees azimuth offset with respect to the sun plane, indicated a slightly better agreement between above- and in-water L&lt;sub&gt;W&lt;/sub&gt; determined for wind speeds tentatively lower than 4 m s&lt;sup&gt;-1&lt;/sup&gt; with rho computed accounting for aerosols, multiple scattering and Cox-Munk surfaces.	Water	225-230	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	60-63
26984064-4	2016	Owing to the intramolecular charge transfer character of DBT, DBT-2EEGIHGHHIISVG is weakly emissive in aqueous solution, but switches to fluoresce upon LAPTM4B proteins specifically bind to the peptide ligand of the probe, which provide the DBT with hydrophobic microenvironment, greatly reducing its charge transfer effect with water.	Water	329-334	lysosomal-associated protein transmembrane 4B	Mus musculus	152-159
27110551-0	2016	Trigonella foenum-graecum water extract improves insulin sensitivity and stimulates PPAR and gamma gene expression in high fructose-fed insulin-resistant rats.	Water	26-31	peroxisome proliferator activated receptor alpha	Rattus norvegicus	84-88
14686431-10	2003	In addition, hypergravity increased the expression levels of genes encoding CCR1 and ERD15, which were shown to take part in the signaling pathway of environmental stimuli such as temperature and water, and those of the alpha-tubulin gene.	Water	196-201	cinnamoyl coa reductase 1	Arabidopsis thaliana	76-80
14686431-10	2003	In addition, hypergravity increased the expression levels of genes encoding CCR1 and ERD15, which were shown to take part in the signaling pathway of environmental stimuli such as temperature and water, and those of the alpha-tubulin gene.	Water	196-201	dehydration-induced protein (ERD15)	Arabidopsis thaliana	85-90
12854955-2	2003	In this contribution I report on two illustrative examples, p21ras and p57, revealing that such mutations have an effect on specific structural deficiencies in the packing of the protein structure, i. e., on backbone hydrogen bonds insufficiently shielded from water attack.	Water	261-266	HRas proto-oncogene, GTPase	Homo sapiens	60-66
26739651-0	2016	Adropin acts in brain to inhibit water drinking: potential interaction with the orphan G protein-coupled receptor, GPR19.	Water	33-38	energy homeostasis associated	Rattus norvegicus	0-7
12888658-0	2003	Down-regulation of proliferating cell nuclear antigen gene expression occurs during cell cycle arrest induced by human fecal water in colonic HT-29 cells.	Water	125-130	proliferating cell nuclear antigen	Homo sapiens	19-53
12888658-7	2003	Interestingly, the mRNA levels of cyclin A and proliferating cell nuclear antigen (PCNA) were dramatically decreased by 69 and 62%, respectively, in HT-29 cells treated with fecal water but not selenite.	Water	180-185	proliferating cell nuclear antigen	Homo sapiens	47-81
12888658-7	2003	Interestingly, the mRNA levels of cyclin A and proliferating cell nuclear antigen (PCNA) were dramatically decreased by 69 and 62%, respectively, in HT-29 cells treated with fecal water but not selenite.	Water	180-185	proliferating cell nuclear antigen	Homo sapiens	83-87
12888658-9	2003	Furthermore, a PCNA gene promoter was cloned into a luciferase reporter construct and its activity was significantly reduced in a dose-dependent manner in cells treated with fecal water but not selenite.	Water	180-185	proliferating cell nuclear antigen	Homo sapiens	15-19
12888658-10	2003	Collectively, these results suggest that human fecal water and selenite can differentially induce growth arrest genes, and that PCNA gene expression is uniquely and highly sensitive to human fecal water.	Water	197-202	proliferating cell nuclear antigen	Homo sapiens	128-132
12943171-6	2003	These results suggest that the retention of water and salt in glycyrrhizin-treated rats is, at least in part, accounted for by the increased expression of AQP 2 and 3 in the kidney, which may be causally related to the MR.	Water	44-49	aquaporin 2	Rattus norvegicus	155-166
12653221-4	2003	Water-immersion-restraint stress (WIRS) increased myeloperoxidase (MPO) activity in gastric mucosa and induced hemorrhagic erosions by a nitrate-inhibitable mechanism.	Water	0-5	myeloperoxidase	Rattus norvegicus	50-65
12653221-4	2003	Water-immersion-restraint stress (WIRS) increased myeloperoxidase (MPO) activity in gastric mucosa and induced hemorrhagic erosions by a nitrate-inhibitable mechanism.	Water	0-5	myeloperoxidase	Rattus norvegicus	67-70
26739651-2	2016	We describe a central nervous system action of adropin to inhibit water drinking and identify a potential adropin receptor, the orphan G protein-coupled receptor, GPR19.	Water	66-71	energy homeostasis associated	Rattus norvegicus	47-54
26739651-3	2016	Reduction in GPR19 mRNA levels in medial basal hypothalamus of male rats resulted in the loss of the inhibitory effect of adropin on water deprivation-induced thirst.	Water	133-138	energy homeostasis associated	Rattus norvegicus	122-129
12870960-2	2003	At pH = 8.0 in water, its deprotonated form [L13 - 3H](3-) reacts with Ln(ClO(4))(3) to give the poorly soluble and stable podates [Ln(L13 - 3H)] (log(beta(110)) = 6.7-7.0, Ln = La-Lu).	Water	15-20	mitochondrial ribosomal protein L13	Homo sapiens	45-48
12538056-1	2003	Glycerol dehydratase (GDH) and diol dehydratase (DDH) are highly homologous isofunctional enzymes that catalyze the elimination of water from glycerol and 1,2-propanediol (1,2-PD) to the corresponding aldehyde via a coenzyme B(12)-dependent radical mechanism.	Water	131-136	aldo-keto reductase family 1 member C1	Homo sapiens	49-52
26890339-1	2016	We have determined by polarized neutron diffraction (PND) the low-temperature molecular magnetic susceptibility tensor of the anisotropic low-spin complex PPh4 [Fe(III) (Tp)(CN)3] H2O.	Water	180-183	potassium two pore domain channel subfamily K member 3	Homo sapiens	155-159
12538056-4	2003	Comparison of this structure and the DDH structure, available only in substrate bound form, shows the expected change of the coordination of the essential K(+) from hexacoordinate to heptacoordinate with the displacement of a single coordinated water by the substrate diol.	Water	245-250	aldo-keto reductase family 1 member C1	Homo sapiens	37-40
12411748-1	2003	The aquaporin-2 (AQP2) water channel is mainly located in the apical plasma membrane of collecting duct epithelial cells, but there has been some evidence of a moderate amount of basolateral localization of AQP2 at least in the inner medullary collecting duct (IMCD).	Water	23-28	aquaporin 2	Rattus norvegicus	4-15
12411748-1	2003	The aquaporin-2 (AQP2) water channel is mainly located in the apical plasma membrane of collecting duct epithelial cells, but there has been some evidence of a moderate amount of basolateral localization of AQP2 at least in the inner medullary collecting duct (IMCD).	Water	23-28	aquaporin 2	Rattus norvegicus	17-21
12853947-3	2003	The deep water formed in the Irminger Sea has the characteristic temperature and salinity of the water mass that fills the mid-depth North Atlantic Ocean, which had been believed to be formed entirely in the Labrador basin.	Water	9-14	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	38-41
12853947-3	2003	The deep water formed in the Irminger Sea has the characteristic temperature and salinity of the water mass that fills the mid-depth North Atlantic Ocean, which had been believed to be formed entirely in the Labrador basin.	Water	97-102	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	38-41
26989466-1	2016	AIM: To investigate the dynamic expression of p-signal transducer and activator of transcription 3 (STAT3) and vascular endothelial growth factor (VEGF) in the formation of gastric tumors induced by drinking water containing N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) in Wistar rats.	Water	208-213	signal transducer and activator of transcription 3	Rattus norvegicus	46-98
26989466-1	2016	AIM: To investigate the dynamic expression of p-signal transducer and activator of transcription 3 (STAT3) and vascular endothelial growth factor (VEGF) in the formation of gastric tumors induced by drinking water containing N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) in Wistar rats.	Water	208-213	signal transducer and activator of transcription 3	Rattus norvegicus	100-105
12834750-2	2003	Tradescantia cuttings bearing young inflorescences were exposed for 6h to 2,4- or 2,6-DNT amended water solutions up to their respective solubilities.	Water	98-103	5', 3'-nucleotidase, cytosolic	Homo sapiens	86-89
26989466-1	2016	AIM: To investigate the dynamic expression of p-signal transducer and activator of transcription 3 (STAT3) and vascular endothelial growth factor (VEGF) in the formation of gastric tumors induced by drinking water containing N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) in Wistar rats.	Water	208-213	vascular endothelial growth factor A	Rattus norvegicus	111-145
26989466-1	2016	AIM: To investigate the dynamic expression of p-signal transducer and activator of transcription 3 (STAT3) and vascular endothelial growth factor (VEGF) in the formation of gastric tumors induced by drinking water containing N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) in Wistar rats.	Water	208-213	vascular endothelial growth factor A	Rattus norvegicus	147-151
26880377-6	2016	Consistent with the observation of differential bindings, ClC-ec1 exhibits markedly variable ability to support the formation of the transient water wires, which are necessary to support the connection of the two H+ transfer sites (Gluin and Gluex), in the presence of different anions.	Water	143-148	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	62-65
12682056-6	2003	Additionally, the thermal stabilization by K+ is significantly reduced in the case of the ArsC E21A mutant, showing the importance of a Glu-21-coordinated water molecule in its contact with K+.	Water	155-160	Arsenate reductase	Staphylococcus aureus	90-94
26811938-2	2016	Herein, we report that nanoarrays of CoP supported on carbon cloth are an efficient bifunctional catalyst for overall water splitting.	Water	118-123	caspase recruitment domain family member 16	Homo sapiens	37-40
12887419-3	2003	ICV infusion of UCN (100 ng/h, 14 days) transiently reduced daily food and water intakes (days 1-4) but body weight was reduced from day 2 into the post-infusion period.	Water	75-80	urocortin	Mus musculus	16-19
12887419-5	2003	SC infusion of UCN caused similar but smaller reductions in food and water intakes and body weight, without change in sodium intake.	Water	69-74	urocortin	Mus musculus	15-18
12891004-4	2003	When the luminal concentration of BSA was changed from 1 to 5.5% at a hydrostatic pressure differential of 5, 10 or 20 cm H2O, no reverse flow (in the reabsorption direction) was observed even though the hydrostatic pressure differential was far below the global osmotic pressure differential.	Water	122-125	albumin	Bos taurus	34-37
26757403-0	2016	Fluorescent Detection of 2,4-DNT and 2,4,6-TNT in Aqueous Media by Using Simple Water-Soluble Pyrene Derivatives.	Water	80-85	5', 3'-nucleotidase, cytosolic	Homo sapiens	29-32
19466013-1	2003	The influence of depth dependent dispersion by the main component of biological tissues, water, on the resolution of OCT was studied.	Water	89-94	plexin A2	Homo sapiens	117-120
26757403-1	2016	Pyrene-containing water-soluble probes for the fluorescent detection of nitroaromatic compounds (NACs), such as explosive components (2,4-DNT and 2,4,6-TNT) and herbicides (2,4-dinitrocresol, 2,4-DNOC), in aqueous media are reported.	Water	18-23	5', 3'-nucleotidase, cytosolic	Homo sapiens	138-141
26843699-2	2016	The results showed that the BC/IGB composite obtained in HS medium (one classical medium for BC production) had a higher water holding capacity, but the water retention capacity of the BC/IGB composite obtained in corncob hydrolysate was better.	Water	121-126	CD79b molecule	Homo sapiens	31-34
26370830-0	2016	The role of hereditary KCNQ1 mutations in water-related death.	Water	42-47	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	23-28
12660245-3	2003	We have previously shown that endogenous expression of the aquaporin-2 (AQP2) water channel in immortalized mouse cortical CD principal cells (mpkCCDC14) grown on filters is dramatically increased by administration of physiological concentrations of AVP.	Water	78-83	aquaporin 2	Mus musculus	59-70
12660245-3	2003	We have previously shown that endogenous expression of the aquaporin-2 (AQP2) water channel in immortalized mouse cortical CD principal cells (mpkCCDC14) grown on filters is dramatically increased by administration of physiological concentrations of AVP.	Water	78-83	aquaporin 2	Mus musculus	72-76
26794461-10	2016	In conclusion, AQP-3 is the pathway for water, glycerol and other small solutes to enter cells, and it may be an essential modulator for the gating of chloride channels.	Water	40-45	aquaporin 3 (Gill blood group)	Homo sapiens	15-20
26820815-1	2016	Previous studies have demonstrated that the expression of aquaporin 3 (AQP3), a water channel which promotes glycerol permeability and water transport across cell membranes, is reduced in degenerative lumbar intervertebral disc (IVD) tissues.	Water	80-85	aquaporin 3 (Gill blood group)	Homo sapiens	58-69
26820815-1	2016	Previous studies have demonstrated that the expression of aquaporin 3 (AQP3), a water channel which promotes glycerol permeability and water transport across cell membranes, is reduced in degenerative lumbar intervertebral disc (IVD) tissues.	Water	80-85	aquaporin 3 (Gill blood group)	Homo sapiens	71-75
26820815-1	2016	Previous studies have demonstrated that the expression of aquaporin 3 (AQP3), a water channel which promotes glycerol permeability and water transport across cell membranes, is reduced in degenerative lumbar intervertebral disc (IVD) tissues.	Water	135-140	aquaporin 3 (Gill blood group)	Homo sapiens	58-69
26820815-1	2016	Previous studies have demonstrated that the expression of aquaporin 3 (AQP3), a water channel which promotes glycerol permeability and water transport across cell membranes, is reduced in degenerative lumbar intervertebral disc (IVD) tissues.	Water	135-140	aquaporin 3 (Gill blood group)	Homo sapiens	71-75
26585348-2	2016	PDI-1 showed strong fluorescence in dimethylformamide (DMF) (Phif = 0.26 (DMF) and moderate fluorescence in water.	Water	108-113	peptidyl arginine deiminase 1	Homo sapiens	0-5
27455701-8	2016	The photo-current densities of CdS NP/GNS nanocomposites were at least three times higher than that of the pristine CdS NPs at the same applied voltage for photoelectrochemical water splitting.	Water	177-182	CDP-diacylglycerol synthase 1	Homo sapiens	31-34
26896089-11	2016	CONCLUSIONS: NDM-1 producing strains present in the hospital environment pose a potential risk and the incubator water may act as a diffusion reservoir of NDM-1- producing bacteria.	Water	113-118	NDM-1	Klebsiella pneumoniae	155-160
26821830-0	2016	Why Is MP2-Water "Cooler" and "Denser" than DFT-Water?	Water	11-16	tryptase pseudogene 1	Homo sapiens	7-10
26821830-0	2016	Why Is MP2-Water "Cooler" and "Denser" than DFT-Water?	Water	48-53	tryptase pseudogene 1	Homo sapiens	7-10
26821830-2	2016	Conversely, ab initio second-order many-body perturbation (MP2) calculations of liquid water require lower temperature and pressure than DFT/GGA to keep water liquid.	Water	87-92	tryptase pseudogene 1	Homo sapiens	59-62
26821830-2	2016	Conversely, ab initio second-order many-body perturbation (MP2) calculations of liquid water require lower temperature and pressure than DFT/GGA to keep water liquid.	Water	153-158	tryptase pseudogene 1	Homo sapiens	59-62
26821830-4	2016	We show that the different temperatures and pressures between DFT/GGA and MP2 at which the simulated water displays the experimentally observed liquid structure under the ambient conditions can be largely explained by their differences in polarizability and dispersion interaction, respectively.	Water	101-106	tryptase pseudogene 1	Homo sapiens	74-77
26821830-7	2016	MP2 gives a stronger dispersion interaction and thus shorter intermolecular distances than dispersionless DFT/GGA, which is why MP2-water is denser than DFT-water under the same external pressure.	Water	132-137	tryptase pseudogene 1	Homo sapiens	0-3
26821830-7	2016	MP2 gives a stronger dispersion interaction and thus shorter intermolecular distances than dispersionless DFT/GGA, which is why MP2-water is denser than DFT-water under the same external pressure.	Water	132-137	tryptase pseudogene 1	Homo sapiens	128-131
26821830-7	2016	MP2 gives a stronger dispersion interaction and thus shorter intermolecular distances than dispersionless DFT/GGA, which is why MP2-water is denser than DFT-water under the same external pressure.	Water	157-162	tryptase pseudogene 1	Homo sapiens	0-3
26821830-7	2016	MP2 gives a stronger dispersion interaction and thus shorter intermolecular distances than dispersionless DFT/GGA, which is why MP2-water is denser than DFT-water under the same external pressure.	Water	157-162	tryptase pseudogene 1	Homo sapiens	128-131
26909090-1	2016	Zein is a water-insoluble polymer from maize seeds that has been widely used to produce carrier particles for the delivery of therapeutic molecules.	Water	10-15	zein	Zea mays	0-4
26706771-0	2016	Marine water from mid-Holocene sea level highstand trapped in a coastal aquifer: Evidence from groundwater isotopes, and environmental significance.	Water	7-12	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	31-34
26706771-8	2016	The configuration suggests surface inundation of the upper sediments by marine water during the mid-Holocene (c. 2-8 kyr BP), when sea level was 1-2m above today"s level.	Water	79-84	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	131-134
26651388-0	2016	Conserved Hydration Sites in Pin1 Reveal a Distinctive Water Recognition Motif in Proteins.	Water	55-60	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	29-33
26651388-2	2016	X-ray crystallographic studies of Pin1 have resolved a number of water molecules around the enzyme, including two highly conserved water molecules within the protein.	Water	65-70	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	34-38
26651388-2	2016	X-ray crystallographic studies of Pin1 have resolved a number of water molecules around the enzyme, including two highly conserved water molecules within the protein.	Water	131-136	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	34-38
26651388-6	2016	Here, we investigate the significance of these structurally conserved water molecules in the catalytic domain of Pin1 using molecular dynamics (MD) simulations, free energy calculations, analysis of X-ray crystal structures, and circular dichroism (CD) experiments.	Water	70-75	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	113-117
26671832-1	2016	The interaction of iridium(iii) with a new lissamine rhodamine B sulfonyl derivative, bearing alanine as a building block, (1) with an orange emission in water results in a green highly emissive Ir@1 complex at room temperature.	Water	154-159	nischarin	Homo sapiens	195-199
26196932-5	2016	The sensor RBP was preliminarily applied to the determination of Al(3+) in water samples from the lake of Henan University and tap water with satisfying results.	Water	75-80	SURP and G-patch domain containing 1	Homo sapiens	11-14
26934923-0	2016	An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components via Niemann-Pick C1-Like 1.	Water	64-69	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	95-117
27375740-0	2016	Chronic Exposure to Arsenic in Drinking Water Causes Alterations in Locomotor Activity and Decreases Striatal mRNA for the D2 Dopamine Receptor in CD1 Male Mice.	Water	40-45	CD1 antigen complex	Mus musculus	147-150
27002905-9	2016	Our results showed that fat deposition-related parameters including fat content in bone marrow and water content in the lumbar vertebra are clearly different between the osteoporosis and non-osteoporosis group, suggesting that both 1H-MRS and in-phase and out-of-phase MRI can be used for diagnosing osteoporosis and monitoring its progression.	Water	99-104	defensin alpha 1	Homo sapiens	232-238
27161213-1	2016	AIM: Glycogen synthase kinase 3 (GSK3) regulates urine concentration by mediating the vasopressin-induced aquaporin 2 expression and water permeability, although it is unknown whether GSK3 also mediates the accumulation of the urea transporter A1 (UT-A1).	Water	133-138	glycogen synthase kinase 3 beta	Mus musculus	5-31
12709058-8	2003	These results suggest that AVP induces the translocation of P-LAP via V2 receptor and P-LAP plays a role in the regulation of excessive AVP level in the renal collecting duct, acting as a negative feedback mechanism for the AVP action of regulating water reabsorption.	Water	249-254	leucyl and cystinyl aminopeptidase	Rattus norvegicus	60-65
12709058-8	2003	These results suggest that AVP induces the translocation of P-LAP via V2 receptor and P-LAP plays a role in the regulation of excessive AVP level in the renal collecting duct, acting as a negative feedback mechanism for the AVP action of regulating water reabsorption.	Water	249-254	leucyl and cystinyl aminopeptidase	Rattus norvegicus	86-91
12877331-6	2003	Zein membranes were also cast from different solvent systems but membrane swelling was not affected by casting solvent and the aqueous channels produced in water are independent of membrane preparation.	Water	156-161	zein	Zea mays	0-4
12639928-9	2003	Investigation of the role of the protein kinases, PI-3 kinase (PI3K) and MAPK, by use of the inhibitors PD098059 and LY294002 demonstrated that the activation of PI3K, but not MAPK, was required to prevent proapoptotic events in cells exposed to H(2)O(2).	Water	246-251	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	50-61
12631357-0	2003	Urinary aquaporin-2 in healthy humans and patients with liver cirrhosis and chronic heart failure during baseline conditions and after acute water load.	Water	141-146	aquaporin 2	Homo sapiens	8-19
12631357-2	2003	Studies in healthy humans have shown that an acute water load reduces the excretion of aquaporin-2 in urine (u-AQP-2).	Water	51-56	aquaporin 2	Homo sapiens	87-98
12631357-2	2003	Studies in healthy humans have shown that an acute water load reduces the excretion of aquaporin-2 in urine (u-AQP-2).	Water	51-56	aquaporin 2	Homo sapiens	111-116
12631357-3	2003	We wanted to test the hypothesis that an acute water load reduces u-AQP-2 less in patients with liver cirrhosis or CHF than in healthy humans.	Water	47-52	aquaporin 2	Homo sapiens	68-73
12643720-0	2003	Single-molecule magnets: two-electron reduced version of a Mn12 complex and environmental influences on the magnetization relaxation of (PPh4)(2)[Mn(12)O(12)(O(2)CCHCl2)(16)(H2O)4].	Water	174-177	potassium two pore domain channel subfamily K member 3	Homo sapiens	137-141
12522669-2	2003	The TPD-MS curves of both H2O and CO2 exhibited two peaks: desorption of H2O and CO2 adsorbed on the particles below 600 degrees C, and liberation of H2O and CO2 in the crystals above 700 degrees C. The increase of carbonate ion content in the particles increased the weight loss in the TPD-TG curves.	Water	26-29	complement C2	Homo sapiens	73-84
14586738-3	2003	In this article, we review the current understanding of the known genetic causes of nephrogenic diabetes insipidus that affect the binding of vasopressin to the V2 receptor and subsequent intracellular signaling events, as well as the translocation of aquaporin-2 water channels to the apical membrane.	Water	264-269	aquaporin 2	Homo sapiens	252-263
12678322-0	2003	Safe water for the Aral Sea Area: could it get any worse?	Water	5-10	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	24-27
12657527-4	2003	We demonstrate that continuous feeding of antigen in the drinking water, as compared to a single feeding or feeding once per day over several days enhances suppression to both Th1 and Th2 type responses in B6D2F1 and BALB/c mice.	Water	66-71	heart and neural crest derivatives expressed 2	Mus musculus	184-187
12590592-9	2003	For both horse cytochrome c and Paracoccus cytochrome c-550, the binding is endothermic and driven by a large entropy change, a pattern consistent with the expulsion of water molecules from the interface.	Water	169-174	cytochrome c, somatic	Equus caballus	15-27
12590592-9	2003	For both horse cytochrome c and Paracoccus cytochrome c-550, the binding is endothermic and driven by a large entropy change, a pattern consistent with the expulsion of water molecules from the interface.	Water	169-174	cytochrome c, somatic	Equus caballus	43-55
12578959-6	2003	In the basal state, perivascular and subpial astroglial end-feet were swollen in brains of alpha-Syn(-/-) mice compared to WT mice, suggesting reduced clearance of water generated by brain metabolism.	Water	164-169	synuclein, alpha	Mus musculus	91-100
12578959-7	2003	When stressed by transient cerebral ischemia, brain edema was attenuated in alpha-Syn(-/-) mice, indicative of reduced water influx.	Water	119-124	synuclein, alpha	Mus musculus	76-85
12802940-5	2003	Venous hypertension interferes with CSF resorption, resulting in increased brain water.	Water	81-86	colony stimulating factor 2	Homo sapiens	36-39
12577965-2	2003	Current data from Mars missions suggesting the presence of liquid water early in Mars" history and mathematical modeling of the fate of water on Mars imply that liquid water may exist deep beneath the surface of Mars.	Water	66-71	methionyl-tRNA synthetase 1	Homo sapiens	81-85
12577965-2	2003	Current data from Mars missions suggesting the presence of liquid water early in Mars" history and mathematical modeling of the fate of water on Mars imply that liquid water may exist deep beneath the surface of Mars.	Water	66-71	methionyl-tRNA synthetase 1	Homo sapiens	81-85
12577965-2	2003	Current data from Mars missions suggesting the presence of liquid water early in Mars" history and mathematical modeling of the fate of water on Mars imply that liquid water may exist deep beneath the surface of Mars.	Water	66-71	methionyl-tRNA synthetase 1	Homo sapiens	81-85
12388383-9	2003	Increased AQP3 expression in senescent rats may also be involved in improved urine-concentrating capacity owing to higher basolateral water and urea reabsorption capacity.	Water	134-139	aquaporin 3 (Gill blood group)	Rattus norvegicus	10-14
12388395-1	2003	The water permeability of the renal collecting duct is regulated by the insertion of aquaporin-2 (AQP2) into the apical plasma membrane of epithelial (principal) cells.	Water	4-9	aquaporin 2	Rattus norvegicus	85-96
12388395-1	2003	The water permeability of the renal collecting duct is regulated by the insertion of aquaporin-2 (AQP2) into the apical plasma membrane of epithelial (principal) cells.	Water	4-9	aquaporin 2	Rattus norvegicus	98-102
12524265-0	2003	Explicit water near the catalytic I helix Thr in the predicted solution structure of CYP2A4.	Water	9-14	cytochrome P450, family 2, subfamily a, polypeptide 4	Mus musculus	85-91
12467044-2	2003	The reaction of a diastereomeric mixture of the ene acetals 2 and 2", derived from racemic norbornene aldehydes (+/-)-1 and chiral nonracemic (S,S)-hydrobenzoin 7, with NBS (0.5-0.6 eq.) in the presence of H(2)O proceeded in a kinetically controlled manner to give the optically pure hydroxy aldehydes 3 along with the intact ene acetals 2".	Water	206-211	nibrin	Homo sapiens	169-172
12498987-7	2003	This suggests that disruption of HO-1 protects against hyperoxia by diminishing the generation of toxic reactive intermediates in the lung via iron and H(2)O(2).	Water	152-157	heme oxygenase 1	Homo sapiens	33-37
12820214-2	2003	This method enables rapid and simple delta(18)O analysis of milligram quantities of water, by employing solid reagent NaHCO(3) as the CO(2) source, a small (0.6 mL) glass vial for the equilibration chamber, and an isotope-monitoring gas chromatography/mass spectrometry (irm-GC/MS) system for delta 18O(CO2) analysis.	Water	84-89	complement C2	Homo sapiens	303-306
15015270-4	2003	RESULT: The water extract of Musk at dose of 5, 20, 80 mg.kg-1 (s.c.) significantly inhibited the chemotaxis of PMN in rat; Musk-1 at concentration of 1-100 micrograms.mL-1 can significantly inhibit the chemotaxis of rabbit PMN in vitro; Musk-1 at concentration of 1-100 micrograms.mL-1 can significantly inhibit the increase of cytosolic Ca2+ concentration in PMN of rat.	Water	12-17	muscle associated receptor tyrosine kinase	Rattus norvegicus	29-33
15015270-4	2003	RESULT: The water extract of Musk at dose of 5, 20, 80 mg.kg-1 (s.c.) significantly inhibited the chemotaxis of PMN in rat; Musk-1 at concentration of 1-100 micrograms.mL-1 can significantly inhibit the chemotaxis of rabbit PMN in vitro; Musk-1 at concentration of 1-100 micrograms.mL-1 can significantly inhibit the increase of cytosolic Ca2+ concentration in PMN of rat.	Water	12-17	muscle associated receptor tyrosine kinase	Rattus norvegicus	124-128
12223490-4	2002	We found that JNK phosphorylated Ser-121 and Thr-163 of Mcl-1 in response to stimulation with H(2)O(2) and that transfection of unphosphorylatable Mcl-1 resulted in an enhanced anti-apoptotic activity in response to stimulation with H(2)O(2).	Water	94-99	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	56-61
12223490-4	2002	We found that JNK phosphorylated Ser-121 and Thr-163 of Mcl-1 in response to stimulation with H(2)O(2) and that transfection of unphosphorylatable Mcl-1 resulted in an enhanced anti-apoptotic activity in response to stimulation with H(2)O(2).	Water	94-99	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	147-152
12223490-4	2002	We found that JNK phosphorylated Ser-121 and Thr-163 of Mcl-1 in response to stimulation with H(2)O(2) and that transfection of unphosphorylatable Mcl-1 resulted in an enhanced anti-apoptotic activity in response to stimulation with H(2)O(2).	Water	233-238	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	56-61
12223490-4	2002	We found that JNK phosphorylated Ser-121 and Thr-163 of Mcl-1 in response to stimulation with H(2)O(2) and that transfection of unphosphorylatable Mcl-1 resulted in an enhanced anti-apoptotic activity in response to stimulation with H(2)O(2).	Water	233-238	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	147-152
12460284-1	2002	The interface between the hypersaline brine and the overlying sea-water (brine-seawater interface) of the Shaban Deep, northern Red Sea was investigated for the presence of microorganisms using the 16S rRNA gene as a molecular marker.	Water	66-71	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	62-65
12194985-0	2002	The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel.	Water	93-98	aquaporin 2	Canis lupus familiaris	81-92
12194985-1	2002	In renal collecting ducts, a vasopressin-induced cAMP increase results in the phosphorylation of aquaporin-2 (AQP2) water channels at Ser-256 and its redistribution from intracellular vesicles to the apical membrane.	Water	116-121	aquaporin 2	Canis lupus familiaris	97-108
12379131-11	2002	The results, therefore, suggest that DAGK"s active site lies very near to the water/bilayer interface.	Water	78-83	diacylglycerol kinase alpha	Homo sapiens	37-41
12388974-2	2002	Specifically, aquaporin 1 (AQP1) and aquaporin 3 (AQP3) have been found to be important in osmotic water movement across membranes.	Water	99-104	aquaporin 3 (Gill blood group)	Homo sapiens	37-48
12388974-2	2002	Specifically, aquaporin 1 (AQP1) and aquaporin 3 (AQP3) have been found to be important in osmotic water movement across membranes.	Water	99-104	aquaporin 3 (Gill blood group)	Homo sapiens	50-54
12234316-1	2002	BACKGROUND: Aquaporin-3 (AQP3) is a member of the water channel family that is selective for the passage of not only water, but also glycerol and urea.	Water	50-55	aquaporin 3 (Gill blood group)	Homo sapiens	12-23
12234316-1	2002	BACKGROUND: Aquaporin-3 (AQP3) is a member of the water channel family that is selective for the passage of not only water, but also glycerol and urea.	Water	50-55	aquaporin 3 (Gill blood group)	Homo sapiens	25-29
12234316-1	2002	BACKGROUND: Aquaporin-3 (AQP3) is a member of the water channel family that is selective for the passage of not only water, but also glycerol and urea.	Water	117-122	aquaporin 3 (Gill blood group)	Homo sapiens	12-23
12234316-1	2002	BACKGROUND: Aquaporin-3 (AQP3) is a member of the water channel family that is selective for the passage of not only water, but also glycerol and urea.	Water	117-122	aquaporin 3 (Gill blood group)	Homo sapiens	25-29
12357555-3	2002	Following irradiation at an MT pulse of 150 Hz downfield from the water proton signal, signal reductions in SPG and RPG were 83.8 +/- 4.7 and 91.4 +/- 5.7%, respectively.	Water	66-71	SPG16	Homo sapiens	108-111
12357555-4	2002	The larger reduction for SPG indicates that an increase in the amount of water in gland cells for the production of more parotid saliva may lead to greater affinity between the protons adjacent to macromolecules and free water which contributes to the MT effect.	Water	73-78	SPG16	Homo sapiens	25-28
12357555-4	2002	The larger reduction for SPG indicates that an increase in the amount of water in gland cells for the production of more parotid saliva may lead to greater affinity between the protons adjacent to macromolecules and free water which contributes to the MT effect.	Water	221-226	SPG16	Homo sapiens	25-28
12377981-0	2002	The carcinogenic response of Tsc2 mutant Long-Evans (Eker) rats to a mixture of drinking water disinfection by-products was less than additive.	Water	89-94	TSC complex subunit 2	Rattus norvegicus	29-33
12193653-4	2002	Overexpressing cells (C17 or C48) degraded H(2)O(2) and t-butylhydroperoxide more rapidly and showed decreased sensitivity to oxidant stress as measured by (51)Cr release.	Water	43-48	cytokine like 1	Homo sapiens	22-25
12185013-13	2002	The roles of AQP-8 and AQP-3 in water absorption remain to be established.	Water	32-37	aquaporin-3	Octodon degus	23-28
12191971-1	2002	Mutations in the Aquaporin-2 gene, which encodes a renal water channel, have been shown to cause autosomal nephrogenic diabetes insipidus (NDI), a disease in which the kidney is unable to concentrate urine in response to vasopressin.	Water	57-62	aquaporin 2	Homo sapiens	17-28
12191971-5	2002	Expression in oocytes revealed that all these mutants, and also AQP2-T125M and AQP2-G175R, conferred a reduced water permeability compared with wt-AQP2, which was due to ER retardation.	Water	111-116	aquaporin 2	Homo sapiens	64-68
12191971-5	2002	Expression in oocytes revealed that all these mutants, and also AQP2-T125M and AQP2-G175R, conferred a reduced water permeability compared with wt-AQP2, which was due to ER retardation.	Water	111-116	aquaporin 2	Homo sapiens	79-83
12191971-5	2002	Expression in oocytes revealed that all these mutants, and also AQP2-T125M and AQP2-G175R, conferred a reduced water permeability compared with wt-AQP2, which was due to ER retardation.	Water	111-116	aquaporin 2	Homo sapiens	79-83
12191971-10	2002	In addition, the reduced single channel water permeability of AQP2-A47V (40%) and AQP2-T125M (25%) might become of therapeutic value when chemical chaperones can be found that restore their routing to the plasma membrane.	Water	40-45	aquaporin 2	Homo sapiens	62-66
12191971-10	2002	In addition, the reduced single channel water permeability of AQP2-A47V (40%) and AQP2-T125M (25%) might become of therapeutic value when chemical chaperones can be found that restore their routing to the plasma membrane.	Water	40-45	aquaporin 2	Homo sapiens	82-86
12139936-1	2002	The interaction of bovine alpha-lactalbumin (BLA) with negatively charged phospholipid bilayers was studied by NMR monitored 1H exchange to characterize the conformational transition that enables a water-soluble protein to associate with and partially insert into a membrane.	Water	198-203	lactalbumin alpha	Bos taurus	26-43
12214855-2	2002	Amygdalin in water is decomposed into benzaldehyde, HCN, and glucose by emulsin, a hydrolysis enzyme in tonin.	Water	13-18	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	52-55
12169772-6	2002	Increases in AP-2 alpha and ATF-2 were sustained throughout the SON during water deprivation, suggesting that these transcription factors could play a role in the maintenance of VP and oxytocin gene transcription in response to dehydration.	Water	75-80	transcription factor AP-2 alpha	Rattus norvegicus	13-23
12102627-3	2002	Here, we have designed, synthesized, and evaluated new lysosomotropic (water-soluble) polymer-cathepsin K inhibitor conjugates.	Water	71-76	cathepsin K	Homo sapiens	94-105
12453634-3	2002	When alpha-synuclein was incubated with both CP and H(2)O(2), alpha-synuclein concomitantly was induced to be aggregated.	Water	52-58	synuclein alpha	Homo sapiens	5-20
12453634-3	2002	When alpha-synuclein was incubated with both CP and H(2)O(2), alpha-synuclein concomitantly was induced to be aggregated.	Water	52-58	synuclein alpha	Homo sapiens	62-77
12146613-4	2002	The water solubility data reported in this work agree well with other recently reported slow-stir measurements and with structure-property model predictions (SPARC and WSKOWWIN).	Water	4-9	secreted protein acidic and cysteine rich	Homo sapiens	158-163
12793676-7	2003	Additionally, rising sea levels will exacerbate salt-water intrusion into freshwater and impact the quality of surface water supplies.	Water	53-58	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	21-24
12501210-0	2002	Surface denaturation and amyloid fibril formation of insulin at model lipid-water interfaces.	Water	76-81	insulin	Bos taurus	53-60
12130981-0	2002	Atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water in canine model with oleic acid-induced pulmonary edema.	Water	90-95	natriuretic peptide A	Canis lupus familiaris	0-26
12130981-9	2002	In the atrial natriuretic peptide group, extravascular lung water was significantly (p &lt;.05) lower and Pao2 was significantly (p &lt;.05) higher than in the control and furosemide groups, respectively.	Water	60-65	natriuretic peptide A	Canis lupus familiaris	7-33
27161213-1	2016	AIM: Glycogen synthase kinase 3 (GSK3) regulates urine concentration by mediating the vasopressin-induced aquaporin 2 expression and water permeability, although it is unknown whether GSK3 also mediates the accumulation of the urea transporter A1 (UT-A1).	Water	133-138	glycogen synthase kinase 3 beta	Mus musculus	33-37
26695234-1	2016	Based on the highly sensitivity and stable-fluorescence of water-soluble CdTe/CdS core-shell quantum dots (QDs) with broad-specificity DNA aptamers, a novel ratiometric detection strategy was proposed for the sensitive detection of organophosphorus pesticides by capillary electrophoresis with laser-induced fluorescence (CE-LIF).	Water	59-64	LIF interleukin 6 family cytokine	Homo sapiens	325-328
12113360-7	2002	Blocked by the less dense fresh water, the movement stops in the halocline where the warm sea water mixes with brackish water.	Water	32-37	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	90-93
12113360-7	2002	Blocked by the less dense fresh water, the movement stops in the halocline where the warm sea water mixes with brackish water.	Water	94-99	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	90-93
12521155-1	2002	Deep-water oxygen concentrations in the Baltic Sea are influenced by eutrophication, but also by saltwater inflows from the North Sea.	Water	5-10	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	47-50
12521155-1	2002	Deep-water oxygen concentrations in the Baltic Sea are influenced by eutrophication, but also by saltwater inflows from the North Sea.	Water	5-10	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	130-133
16290723-1	2002	Liquid-liquid interface of water-hexane provides a unique reaction environment in which CdS nanoparticles capped with mercaptoethylamine could be linked together to form a homodimer with a divalent acid chloride, sebacoyl chloride.	Water	27-32	CDP-diacylglycerol synthase 1	Homo sapiens	88-91
26636353-7	2015	In reduced NQO2, ethidium and AO occupied a more peripheral position in the active site, allowing several water molecules to interact with the polar end of the negatively charged isoalloxazine ring.	Water	106-111	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	11-15
12542207-8	2002	Taken together, these results indicate that the expression of AE2 mRNA is altered in nasal polyp compared with inferior turbinate mucosa, suggesting that the altered expression of these genes in nasal polyp may cause impaired electrolyte and water transport across the epithelial cells.	Water	242-247	solute carrier family 4 member 2	Homo sapiens	62-65
26625010-5	2015	The hydrophobic patch of ubiquitin formed by the side chains of Leu-8, Ile-44, and Val-70 meet all the necessary conditions for a protein-protein binding "hot spot," including the requirement for occlusion of water to nearby hydrophilic sites, and it is suggested that this interaction is responsible for formation of the hydrated noncovalent ubiquitin dimer.	Water	209-214	selectin L	Homo sapiens	64-69
12515896-6	2002	The Abeta lowering effect of 17beta- and 17alpha-estradiol was replicated when estrogens were administered at a more physiological dose in the drinking water, or when mice were ovariectomized at three months of age.	Water	152-157	amyloid beta (A4) precursor protein	Mus musculus	4-9
12001171-1	2002	A kinetic model derived from the ping-pong bi-bi reversible mechanism is proposed to described the acylation of glucose by lauric acid in 2-methyl 2-butanol mediated by Candida antarctica lipase at 60 degrees C. The model accounts for the effect of all four compounds in the reaction mixture, namely lauric acid, glucose, water, and lauroyl glucose ester.	Water	322-327	PAN0_003d1715	Moesziomyces antarcticus	188-194
11916965-7	2002	These results suggest that the reversible inactivation of PTEN by H(2)O(2) might be important for the accumulation of 3"-phosphorylated phosphoinositides and that the uncontrolled generation of H(2)O(2) associated with certain pathological conditions might contribute to cell proliferation by inhibiting PTEN function.	Water	66-71	phosphatase and tensin homolog	Homo sapiens	58-62
12776536-4	2002	Among these test samples, AE, petrol fraction (AE-1) and water soluble fraction (AE-4) were more potent, but there was no significant difference between them.	Water	57-62	solute carrier family 4, sodium bicarbonate cotransporter, member 9	Mus musculus	81-85
26310817-3	2015	Vasopressin controls osmotic water transport in the renal collecting duct through regulation of aquaporin-2 (AQP2).	Water	29-34	aquaporin 2	Mus musculus	96-107
12239222-1	2002	AQP3 is a water and glycerol channel present on human erythrocytes and in various tissues.	Water	10-15	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
11916965-7	2002	These results suggest that the reversible inactivation of PTEN by H(2)O(2) might be important for the accumulation of 3"-phosphorylated phosphoinositides and that the uncontrolled generation of H(2)O(2) associated with certain pathological conditions might contribute to cell proliferation by inhibiting PTEN function.	Water	66-71	phosphatase and tensin homolog	Homo sapiens	304-308
11916965-7	2002	These results suggest that the reversible inactivation of PTEN by H(2)O(2) might be important for the accumulation of 3"-phosphorylated phosphoinositides and that the uncontrolled generation of H(2)O(2) associated with certain pathological conditions might contribute to cell proliferation by inhibiting PTEN function.	Water	194-199	phosphatase and tensin homolog	Homo sapiens	58-62
12193876-17	2002	Water flows into principal cells from collecting duct lumen through AQP2 and flows out to interstitium through AQP3 and AQP4 and finally reachs blood circulation through AQP1 capillaries.	Water	0-5	aquaporin 2	Homo sapiens	68-72
12193876-17	2002	Water flows into principal cells from collecting duct lumen through AQP2 and flows out to interstitium through AQP3 and AQP4 and finally reachs blood circulation through AQP1 capillaries.	Water	0-5	aquaporin 3 (Gill blood group)	Homo sapiens	111-115
12445685-8	2002	The distribution of the aquaporin-4 (AQP-4) water channel was also examined using dye-filled hippocampal astrocytes.	Water	44-49	aquaporin 4	Rattus norvegicus	24-35
26565933-2	2015	The crystalline sample (NaK-D-1) of the water-soluble, mixed sodium/potassium salt of D-1 was obtained in the 14.7% yield, which has been characterized by complete elemental analysis, TG/DTA, FTIR, single-crystal X-ray structure analysis, and solution ((183)W, (31)P, (1)H and (13)C{(1)H}) NMR spectroscopy.	Water	40-45	TANK binding kinase 1	Homo sapiens	24-27
12445685-8	2002	The distribution of the aquaporin-4 (AQP-4) water channel was also examined using dye-filled hippocampal astrocytes.	Water	44-49	aquaporin 4	Rattus norvegicus	37-42
12064807-5	2002	When TNF-alpha was inoculated by intravenous administration, a strong inhibition on the L-leucine uptake (about 40%), mediated by a secretagogue effect on water and Cl-ions was induced.	Water	155-160	tumor necrosis factor	Oryctolagus cuniculus	5-14
12451215-5	2002	Individuals with a CSF pressure higher than 200 mm H2O should undergo MRV to exclude cerebral venous thrombosis.	Water	51-54	colony stimulating factor 2	Homo sapiens	19-22
12137754-3	2002	AQP1 did not show any significant change of water permeability when treated with CT. An adenylyl cyclase accelerator forskolin showed similar effects as CT did, suggesting that changes of the water permeability of AQP4 and AQP3 were due to an increase of intracellular cAMP concentration.	Water	192-197	aquaporin 3 (Gill blood group)	Homo sapiens	223-227
26628323-4	2015	Here we report an experiment of a siphon operating at sea level at a height of 15 m, well above 10 m. Prior degassing of the water prevented cavitation.	Water	125-130	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	54-57
26630491-1	2015	Aquaporins (AQP) are water channel proteins and the genes coding for AQP2, AQP5, and AQP6 are clustered in 12q13.	Water	21-26	aquaporin 5	Homo sapiens	75-79
12019144-5	2002	We tested one such drug, cyclophosphamide (CTX), in a protocol wherein the drug was administered to mice at low doses, of approximately 10-40 mg/kg on a daily basis through the drinking water.	Water	186-191	V-set and immunoglobulin domain containing 2	Mus musculus	43-46
12427043-8	2002	Only noncooperative thermal transitions were observed for the PHF samples in acetate buffer and water, consistent with the presence of a heterogeneous population of folded structures.	Water	96-101	microtubule associated protein tau	Homo sapiens	62-65
26630491-1	2015	Aquaporins (AQP) are water channel proteins and the genes coding for AQP2, AQP5, and AQP6 are clustered in 12q13.	Water	21-26	aquaporin 6	Homo sapiens	85-89
12613030-7	2002	The results obtained indicate that the Gd3+ ion is immobilised in the interior of the zeolite and that the relaxivity is mainly limited by the relatively slow diffusion of water protons from the pores of the zeolite channels into the bulk water.	Water	172-177	GRDX	Homo sapiens	39-42
12613030-7	2002	The results obtained indicate that the Gd3+ ion is immobilised in the interior of the zeolite and that the relaxivity is mainly limited by the relatively slow diffusion of water protons from the pores of the zeolite channels into the bulk water.	Water	239-244	GRDX	Homo sapiens	39-42
11961000-10	2002	Water loading led to a similar reduction in papillary Cox mRNA expression and PGE(2) content like furosemide.	Water	0-5	coproporphyrinogen oxidase	Rattus norvegicus	54-57
26379215-2	2015	A water-in-oil emulsion is generated feasibly from a mixture of water and a solution of disulfide-containing hyperbranched PEGylated poly(amido amine)s, poly(BAC2-AMPD1)-PEG, in chloroform.	Water	2-7	adenosine monophosphate deaminase 1	Homo sapiens	163-168
12021537-0	2002	Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis.	Water	33-38	aquaporin 2	Homo sapiens	21-32
12021537-1	2002	We studied the changes in plasma arginine vasopressin (AVP) and urinary excretion of aquaporin-2 (UAQP-2) water channel in 3 patients with diabetic ketoacidosis.	Water	106-111	aquaporin 2	Homo sapiens	85-96
12361715-1	2002	Factor B is a water-soluble protein, which is required for the coupled activity of the mitochondrial ATP synthase complex.	Water	14-19	distal membrane arm assembly component 2 like	Bos taurus	0-8
26379215-3	2015	The water droplets in the emulsion are stabilized and filled with poly(BAC2-AMPD1)-PEG, and the crosslinked poly(amido amine)s nanogels are formed via the intermolecular disulfide exchange reaction.	Water	4-9	adenosine monophosphate deaminase 1	Homo sapiens	76-81
25968479-5	2015	Leptin deficient mice depicted permanently increased water diffusion parameters under all feeding conditions as compared to wild type controls, without important changes upon fasting or recovery.	Water	53-58	leptin	Mus musculus	0-6
12161445-5	2002	Likewise, hyperoxidation of Cys(172)/Ser(172) mutant Prx I required not only H(2)O(2), but also a catalysis-supporting thiol (dithiothreitol).	Water	77-82	peroxiredoxin 1	Homo sapiens	53-58
12161445-6	2002	Kinetic analysis of Prx I inactivation in the presence of a low steady-state level (&lt;1 microm) of H(2)O(2) indicated that Prx I was hyperoxidized at a rate of 0.072% per turnover at 30 degrees C. Hyperoxidation of Prx I was also detected in HeLa cells treated with H(2)O(2).	Water	101-106	peroxiredoxin 1	Homo sapiens	20-25
12161445-6	2002	Kinetic analysis of Prx I inactivation in the presence of a low steady-state level (&lt;1 microm) of H(2)O(2) indicated that Prx I was hyperoxidized at a rate of 0.072% per turnover at 30 degrees C. Hyperoxidation of Prx I was also detected in HeLa cells treated with H(2)O(2).	Water	101-106	peroxiredoxin 1	Homo sapiens	125-130
12161445-6	2002	Kinetic analysis of Prx I inactivation in the presence of a low steady-state level (&lt;1 microm) of H(2)O(2) indicated that Prx I was hyperoxidized at a rate of 0.072% per turnover at 30 degrees C. Hyperoxidation of Prx I was also detected in HeLa cells treated with H(2)O(2).	Water	101-106	peroxiredoxin 1	Homo sapiens	125-130
12051852-5	2002	At the bottom of this cleft, the catalytic zinc ion is coordinated tetrahedrally and lacks the zinc-bound water molecule that is usually found in ADH apoform structures.	Water	106-111	glucose 1-dehydrogenase	Saccharolobus solfataricus	146-149
11929977-10	2002	The function of the 2-Cys Prx is therefore not confined to its role in the water-water cycle pathway for energy dissipation in photosynthesis but also mediates peroxide detoxification in the plastids during the dark phase.	Water	75-80	periaxin	Homo sapiens	26-29
12161445-6	2002	Kinetic analysis of Prx I inactivation in the presence of a low steady-state level (&lt;1 microm) of H(2)O(2) indicated that Prx I was hyperoxidized at a rate of 0.072% per turnover at 30 degrees C. Hyperoxidation of Prx I was also detected in HeLa cells treated with H(2)O(2).	Water	268-273	peroxiredoxin 1	Homo sapiens	125-130
12161445-6	2002	Kinetic analysis of Prx I inactivation in the presence of a low steady-state level (&lt;1 microm) of H(2)O(2) indicated that Prx I was hyperoxidized at a rate of 0.072% per turnover at 30 degrees C. Hyperoxidation of Prx I was also detected in HeLa cells treated with H(2)O(2).	Water	268-273	peroxiredoxin 1	Homo sapiens	125-130
11929977-10	2002	The function of the 2-Cys Prx is therefore not confined to its role in the water-water cycle pathway for energy dissipation in photosynthesis but also mediates peroxide detoxification in the plastids during the dark phase.	Water	81-86	periaxin	Homo sapiens	26-29
25612082-12	2015	Leptin increased in the casein (1.016-3.246 ng mL(-1) , P &lt; 0.001; 0.952-3.294 ng mL(-1) , P &lt; 0.001) and whey groups (0.135-2.273 ng mL(-1) , P = 0.027; 0.069-2.322, P = 0.038) compared with water and pre-test control group, respectively.	Water	198-203	leptin	Homo sapiens	0-6
11880267-9	2002	The cellular distribution and changes in expression indicate that parchorin plays an important role, possibly in chloride transport, in the cells that create an ion gradient for water movement.	Water	178-183	chloride intracellular channel protein 6	Oryctolagus cuniculus	66-75
12209469-12	2002	Studies with water-soluble and membrane-bound fluorescence quenchers demonstrated that Trp(3) is located close to the water-membrane interface.	Water	13-18	tRNA-Pro (anticodon TGG) 3-1	Homo sapiens	87-93
12209469-12	2002	Studies with water-soluble and membrane-bound fluorescence quenchers demonstrated that Trp(3) is located close to the water-membrane interface.	Water	118-123	tRNA-Pro (anticodon TGG) 3-1	Homo sapiens	87-93
26607179-3	2015	Here we show that Arabidopsis AtPIP1;4 is a plasma membrane sensor of Hpa1 and plays a dual role in plasma membrane permeability of CO2 and H2O.	Water	140-143	histidinol phosphate aminotransferase 1	Arabidopsis thaliana	70-74
12364388-3	2002	Guinea pig ventricular myocytes were dialyzed with catalase, which specifically catalyzes the conversion of H2O2 to H2O and oxygen, and then I(Ca-L) was recorded during exposure to isoproterenol (Iso).	Water	108-111	catalase	Cavia porcellus	51-59
11981647-8	2002	RESULTS: IFN-beta at doses of either 10(4) or 10(5) IU significantly reduced both the clinical and histopathological severity of EAU.	Water	129-132	interferon beta 1	Rattus norvegicus	9-17
11929850-4	2002	When co-expressed, AQP2-727deltaG, but not a mutant in recessive NDI (AQP2-R187C), formed hetero-oligomers with wild-type (wt) AQP2 and reduced the water permeability of these oocytes, because of a reduced plasma membrane expression of wt-AQP2.	Water	148-153	aquaporin 2	Homo sapiens	19-23
26573329-5	2015	In the NRN complex, a water molecule, which is an essential substrate for ADO formation, is structurally identified for the first time as the candidate donor in a Michael addition by SAHH to the 3"-keto-4",5"-didehydroadenosine reaction intermediate.	Water	22-27	adenosylhomocysteinase	Homo sapiens	183-187
11782489-1	2002	Fine regulation of water reabsorption by the antidiuretic hormone [8-arginine]vasopressin (AVP) occurs in principal cells of the collecting duct and is largely dependent on regulation of the aquaporin-2 (AQP2) water channel.	Water	19-24	aquaporin 2	Mus musculus	191-202
11782489-1	2002	Fine regulation of water reabsorption by the antidiuretic hormone [8-arginine]vasopressin (AVP) occurs in principal cells of the collecting duct and is largely dependent on regulation of the aquaporin-2 (AQP2) water channel.	Water	19-24	aquaporin 2	Mus musculus	204-208
11782489-1	2002	Fine regulation of water reabsorption by the antidiuretic hormone [8-arginine]vasopressin (AVP) occurs in principal cells of the collecting duct and is largely dependent on regulation of the aquaporin-2 (AQP2) water channel.	Water	210-215	aquaporin 2	Mus musculus	191-202
11782489-1	2002	Fine regulation of water reabsorption by the antidiuretic hormone [8-arginine]vasopressin (AVP) occurs in principal cells of the collecting duct and is largely dependent on regulation of the aquaporin-2 (AQP2) water channel.	Water	210-215	aquaporin 2	Mus musculus	204-208
12226838-5	2002	The effect of IFN-gamma was still observed in the presence of H(2)O(2), which enhances the expression and activity of P-gp.	Water	62-67	interferon gamma	Rattus norvegicus	14-23
26421324-2	2015	In aqueous solution, 2-thiophenone and 4-hydroxymethyl-1,3-dioxolan-2-one (HD) at a concentration of 2% by volume can increase the average charge of cytochrome c and myoglobin by up to 163%, resulting in even higher charge states than those that are produced from water/methanol/acid solutions in which these proteins are denatured.	Water	264-269	myoglobin	Homo sapiens	166-175
12218327-4	2002	After an 8-hour water deprivation, both urinary osmolality (U(osm)) and urinary excretion of AQP-2 significantly decreased in the diabetic patients with chronic renal failure as compared to the control subjects (p &lt; 0.0001, p &lt; 0.05, respectively).	Water	16-21	aquaporin 2	Homo sapiens	93-98
12218327-5	2002	After a water load (10 ml/kg), no differences were found in plasma osmolality (P(osm)), AVP levels and U(osm), whereas urinary excretion of AQP-2 significantly decreased in the patients with chronic renal failure as compared to the control subjects (p &lt; 0.05).	Water	8-13	aquaporin 2	Homo sapiens	140-145
11867526-3	2002	To test whether GPC-1 is involved in sensory plasticity, we developed a water soluble compound adaptation assay.	Water	72-77	Guanine nucleotide-binding protein subunit gamma	Caenorhabditis elegans	16-21
26578982-1	2015	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and plays an important role in the maintenance of body water homeostasis.	Water	48-53	aquaporin 2	Homo sapiens	0-11
12191695-4	2002	In this study, bovine insulin was dissolved in deionized water alone or with tyloxapol, lactose or trehalose.	Water	57-62	insulin	Bos taurus	22-29
26578982-1	2015	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and plays an important role in the maintenance of body water homeostasis.	Water	48-53	aquaporin 2	Homo sapiens	13-17
11874481-0	2002	Altered water barrier function in epidermal-type fatty acid binding protein-deficient mice.	Water	8-13	fatty acid binding protein 5, epidermal	Mus musculus	34-75
26578982-1	2015	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and plays an important role in the maintenance of body water homeostasis.	Water	82-87	aquaporin 2	Homo sapiens	0-11
11874481-7	2002	The molecular mechanism by which epidermal-type fatty acid binding protein contributes to the water barrier function of the skin remains to be elucidated.	Water	94-99	fatty acid binding protein 5, epidermal	Mus musculus	33-74
12124294-5	2002	Then, HbC crystallization is only possible because of the huge entropy gain of 610 J mol(-1) K(-1), likely stemming from the release of up to 10 water molecules per protein intermolecular contact-hydrophobic interaction.	Water	145-150	keratin 88, pseudogene	Homo sapiens	6-9
26578982-1	2015	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and plays an important role in the maintenance of body water homeostasis.	Water	82-87	aquaporin 2	Homo sapiens	13-17
26578982-1	2015	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and plays an important role in the maintenance of body water homeostasis.	Water	82-87	aquaporin 2	Homo sapiens	0-11
11870235-2	2002	At room temperature, in Tris-HCl buffer (pH 7.4), both ASC and BH(4) were readily oxidized by dissolved O(2) or H(2)O(2).	Water	112-117	steroid sulfatase	Homo sapiens	55-58
26578982-1	2015	Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and plays an important role in the maintenance of body water homeostasis.	Water	82-87	aquaporin 2	Homo sapiens	13-17
26578982-8	2015	Functionally, dexamethasone treatment of oocytes injected with an AQP2 cRNA increased water transport activity as judged by cell rupture time in a hypo-osmotic solution (66 +- 13 s in dexamethasone vs. 101 +- 11 s in control, n = 15).	Water	86-91	aquaporin 2	Homo sapiens	66-70
11870235-4	2002	Addition of 36 micromol/l BH(4) to 143 micromol/l ASC increased the initial rate of ASC oxidation 3.2-fold in a catalase-sensitive manner, indicating that enhanced ASC oxidation is partly due to the formation of H(2)O(2).	Water	212-217	steroid sulfatase	Homo sapiens	50-53
11870235-4	2002	Addition of 36 micromol/l BH(4) to 143 micromol/l ASC increased the initial rate of ASC oxidation 3.2-fold in a catalase-sensitive manner, indicating that enhanced ASC oxidation is partly due to the formation of H(2)O(2).	Water	212-217	steroid sulfatase	Homo sapiens	84-87
12145768-1	2002	Previous studies showed that aquaporin 2 (AQP2) is elevated in the kidney of the heart failure rat suggesting that an increased amount of AQP2 contributes to water retention in heart failure.	Water	158-163	aquaporin 2	Rattus norvegicus	29-40
12145768-1	2002	Previous studies showed that aquaporin 2 (AQP2) is elevated in the kidney of the heart failure rat suggesting that an increased amount of AQP2 contributes to water retention in heart failure.	Water	158-163	aquaporin 2	Rattus norvegicus	42-46
12145768-1	2002	Previous studies showed that aquaporin 2 (AQP2) is elevated in the kidney of the heart failure rat suggesting that an increased amount of AQP2 contributes to water retention in heart failure.	Water	158-163	aquaporin 2	Rattus norvegicus	138-142
11870235-4	2002	Addition of 36 micromol/l BH(4) to 143 micromol/l ASC increased the initial rate of ASC oxidation 3.2-fold in a catalase-sensitive manner, indicating that enhanced ASC oxidation is partly due to the formation of H(2)O(2).	Water	212-217	steroid sulfatase	Homo sapiens	84-87
26450357-6	2015	Under the optimum conditions, a good linearity was achieved in the concentration range of 0.1-50.0 ng mL-1 for bottled water sample and 0.2-50.0 ng mL-1 for peach juice and soft drink samples.	Water	119-124	L1 cell adhesion molecule	Mus musculus	102-106
11788448-1	2002	Renal regulation of mammalian water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which is expressed in the apical and basolateral membranes of proximal tubules and descending limbs of Henle, and aquaporin-2 (AQP2), which is redistributed from intracellular vesicles to the apical membrane (AM) of collecting duct cells with vasopressin.	Water	30-35	aquaporin 2	Homo sapiens	215-226
11788448-1	2002	Renal regulation of mammalian water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which is expressed in the apical and basolateral membranes of proximal tubules and descending limbs of Henle, and aquaporin-2 (AQP2), which is redistributed from intracellular vesicles to the apical membrane (AM) of collecting duct cells with vasopressin.	Water	30-35	aquaporin 2	Homo sapiens	228-232
11788448-1	2002	Renal regulation of mammalian water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which is expressed in the apical and basolateral membranes of proximal tubules and descending limbs of Henle, and aquaporin-2 (AQP2), which is redistributed from intracellular vesicles to the apical membrane (AM) of collecting duct cells with vasopressin.	Water	86-91	aquaporin 2	Homo sapiens	215-226
11788448-1	2002	Renal regulation of mammalian water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which is expressed in the apical and basolateral membranes of proximal tubules and descending limbs of Henle, and aquaporin-2 (AQP2), which is redistributed from intracellular vesicles to the apical membrane (AM) of collecting duct cells with vasopressin.	Water	86-91	aquaporin 2	Homo sapiens	228-232
26399297-4	2015	Analyses of the main interactions in the active site of DPP-4, in particular, the contribution of the hydroxyl coordination between Tyr547 and Ser630 by the water molecule, which is described in the literature as important for the coordinated interactions in the active site, were performed.	Water	157-162	dipeptidyl peptidase 4	Homo sapiens	56-61
11723127-8	2002	Consistent with these in vitro observations, exposure of mice to arsenic in drinking water, which has been found previously to be associated with AP-1 activation and epithelial proliferation, induces EGFR and ERK activation in the urinary bladder.	Water	85-90	epidermal growth factor receptor	Mus musculus	200-204
12162707-2	2002	14C-VEGF was encapsulated using a solid-in-oil-in-water emulsification method.	Water	50-55	vascular endothelial growth factor A	Rattus norvegicus	4-8
12297463-0	2002	Enzyme-linked immunosorbent assay for urinary aquaporin-2 water channel protein measurement.	Water	58-63	aquaporin 2	Rattus norvegicus	46-57
26493912-7	2015	Further, modes for vibration and energy-transfer via hydrogen bonds in sI hydrate were found to occur at higher frequencies vis-a-vis ice Ih and sII hydrate in both the water-librational and OH H regions because of the more strained nature of hydrogen bonds therein.	Water	169-174	transcription elongation factor A1	Homo sapiens	145-148
12297463-1	2002	OBJECTIVE: To develop an efficient and stable enzyme-linked immunosorbent assay (ELISA) for detecting urinary aquaporin-2 (AQP2) water channel protein.	Water	129-134	aquaporin 2	Rattus norvegicus	110-121
12297463-1	2002	OBJECTIVE: To develop an efficient and stable enzyme-linked immunosorbent assay (ELISA) for detecting urinary aquaporin-2 (AQP2) water channel protein.	Water	129-134	aquaporin 2	Rattus norvegicus	123-127
12102660-0	2002	Effect of skin barrier competence on SLS and water-induced IL-1alpha expression.	Water	45-50	interleukin 1 alpha	Homo sapiens	59-68
12168312-8	2002	CONCLUSION: Patients with moderately elevated resistance to CSF outflow (12-18 mm Hg/(ml/min)) cannot possibly react to changes of the valve"s settings above 100 mm H2O.	Water	165-168	colony stimulating factor 2	Homo sapiens	60-63
12102660-4	2002	Furthermore, we have determined the effect of water, the vehicle for SLS, on IL-1alpha mRNA levels.	Water	46-51	interleukin 1 alpha	Homo sapiens	77-86
26269596-0	2015	Biased Gs versus Gq proteins and beta-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network.	Water	111-116	tachykinin receptor 1	Homo sapiens	64-76
12102660-5	2002	Topical application of water to excised skin increases IL-1alpha mRNA levels sixfold in the epidermis whereas topical application of water to EpiDerm cultures did not alter IL-1alpha mRNA levels.	Water	23-28	interleukin 1 alpha	Homo sapiens	55-64
12102660-9	2002	An additional increase in IL-1alpha mRNA levels observed between topical application of water and SLS is similar (about threefold) in both experimental systems.	Water	88-93	interleukin 1 alpha	Homo sapiens	26-35
12102660-13	2002	Our results show clearly that the topical application of water to excised skin results in increased levels of IL-1alpha mRNA in the epidermis.	Water	57-62	interleukin 1 alpha	Homo sapiens	110-119
11944057-1	2002	Toxic water soluble polymeric 3-alkylpyridinium salts isolated from the sponge Raniera sarai strongly inhibited AChE in vitro.	Water	6-11	acetylcholinesterase	Rattus norvegicus	112-116
25220852-5	2015	The sequence also contained a putative N-glycosylation site and phosphorylation motifs for protein kinase A and protein kinase C. The oocyte swelling assay showed that AQP-x2 facilitated water permeability.	Water	187-192	aquaporin-Xl2	Xenopus laevis	168-174
11810216-4	2002	Resting pHi was slightly but significantly higher in both DTLs and ATLs in high osmolality ( approximately 670 mosmol/kg H2O) than in low osmolality ( approximately 290 mosmol/kg H2O) medium but not when sucrose replaced urea.	Water	121-124	glucose-6-phosphate isomerase	Rattus norvegicus	8-11
11810216-4	2002	Resting pHi was slightly but significantly higher in both DTLs and ATLs in high osmolality ( approximately 670 mosmol/kg H2O) than in low osmolality ( approximately 290 mosmol/kg H2O) medium but not when sucrose replaced urea.	Water	179-182	glucose-6-phosphate isomerase	Rattus norvegicus	8-11
11773613-4	2002	AQP2 is exclusively expressed in the principal cells of the connecting tubule and collecting duct and is the predominant vasopressin-regulated water channel.	Water	143-148	aquaporin 2	Homo sapiens	0-4
11773613-5	2002	AQP3 and AQP4 are both present in the basolateral plasma membrane of collecting duct principal cells and represent exit pathways for water reabsorbed apically via AQP2.	Water	133-138	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
12050236-1	2002	Mutations in the aquaporin-2 gene (AQP2), encoding the vasopressin-regulated water channel of the renal collecting duct, are responsible for the autosomal recessive or dominant forms of congenital nephrogenic diabetes insipidus.	Water	77-82	aquaporin 2	Homo sapiens	17-28
12050236-1	2002	Mutations in the aquaporin-2 gene (AQP2), encoding the vasopressin-regulated water channel of the renal collecting duct, are responsible for the autosomal recessive or dominant forms of congenital nephrogenic diabetes insipidus.	Water	77-82	aquaporin 2	Homo sapiens	35-39
12053053-1	2002	The regulation of aquaporin-2 (AQP2) water channel excretion in the collecting duct depends mainly on the action of vasopressin (AVP).	Water	37-42	aquaporin 2	Homo sapiens	18-29
11773613-5	2002	AQP3 and AQP4 are both present in the basolateral plasma membrane of collecting duct principal cells and represent exit pathways for water reabsorbed apically via AQP2.	Water	133-138	aquaporin 2	Homo sapiens	163-167
11773613-11	2002	Vasopressin regulates acutely the water permeability of the kidney collecting duct by trafficking of AQP2 from intracellular vesicles to the apical plasma membrane.	Water	34-39	aquaporin 2	Homo sapiens	101-105
12053053-1	2002	The regulation of aquaporin-2 (AQP2) water channel excretion in the collecting duct depends mainly on the action of vasopressin (AVP).	Water	37-42	aquaporin 2	Homo sapiens	31-35
25220852-12	2015	The results suggest that the poor responsiveness of AQP-x2 to neurohypophyseal peptides may be a main cause for the little water permeability of the urinary bladder of X. laevis.	Water	123-128	aquaporin-Xl2	Xenopus laevis	52-58
12436927-8	2002	Using this model, we demonstrated that the onset of vasopressin escape (increased urine volume coupled to decreased urine osmolality) coincided temporally with a marked decrease in renal aquaporin-2 (water channel) protein and mRNA expression in renal collecting ducts.	Water	200-205	aquaporin 2	Rattus norvegicus	187-198
26003495-12	2015	5) GHSR-null and WT mice learned to prefer a CS+ flavor paired with IG fat (Intralipid) over a CS- flavor paired with IG water.	Water	121-126	growth hormone secretagogue receptor	Mus musculus	3-7
12003149-3	2002	Chromatographic column experiments show that Cd2+ sorption on silica can be considered as a reversible equilibrate reaction which depends on water composition and pH.	Water	141-146	CD2 molecule	Homo sapiens	45-48
26003495-13	2015	GHSR-null and WT mice also learned to prefer a CS+ flavor added to 8% fructose over a CS- added to water.	Water	99-104	growth hormone secretagogue receptor	Mus musculus	0-4
12082170-2	2002	By molecular modeling, we predicted that the 6-20 fragment of apo C-III is obliquely orientated at the lipid/water interface owing to an asymmetric distribution of the hydrophobic residues when helical.	Water	109-114	apolipoprotein C3	Homo sapiens	62-71
26419740-2	2015	Aquaporin-4 (Aqp4), an astrocytic transmembrane water channel, is an important molecular contributor to cerebral edema formation.	Water	48-53	aquaporin 4	Rattus norvegicus	0-11
11735543-2	2001	The reaction proceeds in DMF/water in the presence of potassium carbonate and catalytic palladium(II) acetate and is compatible with both electron-donating and -withdrawing substituents in the para position of the aniline, and with an alkyl substituent at C-2 of the dienyl sulfone.	Water	29-34	complement C2	Homo sapiens	256-259
26419740-2	2015	Aquaporin-4 (Aqp4), an astrocytic transmembrane water channel, is an important molecular contributor to cerebral edema formation.	Water	48-53	aquaporin 4	Rattus norvegicus	13-17
12027161-4	2002	For the specific cases of a soot particle coated with a water layer and an ice sphere containing an air bubble, the phase-matrix elements -P12/P11 and P33/P11 are unique if the shell is thin.	Water	56-61	endonuclease, poly(U) specific	Homo sapiens	143-146
26286865-4	2015	(3) In systems containing both H2O and CO2, the NOM molecules adopt equilibrium positions at the H2O-CO2 interface with the more hydrophilic structural elements facing the H2O and the more hydrophobic ones facing the CO2.	Water	97-100	complement C2	Homo sapiens	31-42
11747033-6	2001	Upon granulocyte colony stimulating factor treatment, the water proton signal in the lumbar spine is not further augmented.	Water	58-63	colony stimulating factor 3	Homo sapiens	5-42
26275020-2	2015	Importantly, hybrid microtubules as a microreactor were successfully prepared by directly reducing AuCl4(-) on the surface of Bola-AP5-based tubular structures in water.	Water	163-168	adaptor related protein complex 5 subunit beta 1	Homo sapiens	131-134
11894976-19	2001	Group II serum leptin levels increased after both alcohol and water during the initial part of the night (18.00-20.00 hours).	Water	62-67	leptin	Homo sapiens	15-21
11988338-1	2002	The cerebral Aquaporin-4 (AQP4) water channel is suggested to be involved in brain edema formation aggravated by reduced cerebral blood flow early after traumatic brain injury (TBI).	Water	32-37	aquaporin 4	Rattus norvegicus	13-24
11988338-1	2002	The cerebral Aquaporin-4 (AQP4) water channel is suggested to be involved in brain edema formation aggravated by reduced cerebral blood flow early after traumatic brain injury (TBI).	Water	32-37	aquaporin 4	Rattus norvegicus	26-30
11714376-5	2001	The subchronic administration of PA (0.1% in drinking water) for 60 days showed not only a significant decrease in the GSH level in kidney but also a significant enhancement of ALT activity in plasma.	Water	54-59	glutamic pyruvic transaminase, soluble	Mus musculus	177-180
12175780-8	2002	However, the activity of 1alpha,25(OH)2-3-epi-D3 when compared to 1alpha,25(OH)2D3 in generating VDR-mediated transcriptional activity in ROS 17/2.8 cells transfected with human osteocalcin VDRE/growth hormone gene construct, was significantly reduced.	Water	34-39	vitamin D receptor	Rattus norvegicus	97-100
26301920-5	2015	The host-guest interaction of Ibu-CD2 induced the formation of branched supramolecular polymers (SPs) in pure water, whereas the hydrophilic-hydrophobic interaction generated spherical or irregular micelles in water/organic mixtures.	Water	110-115	CD2 molecule	Homo sapiens	34-37
26301920-5	2015	The host-guest interaction of Ibu-CD2 induced the formation of branched supramolecular polymers (SPs) in pure water, whereas the hydrophilic-hydrophobic interaction generated spherical or irregular micelles in water/organic mixtures.	Water	210-215	CD2 molecule	Homo sapiens	34-37
11972040-0	2002	Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.	Water	28-33	rhodopsin	Bos taurus	47-56
11972040-4	2002	Here we have explored the functional role of water molecules in the transmembrane region of bovine rhodopsin by using x-ray diffraction to 2.6 A.	Water	45-50	rhodopsin	Bos taurus	99-108
11595384-8	2001	The elimination of the DMPO-*OH adduct was determined to be due to the ability of ceruloplasmin to completely reduce oxygen to water during the oxidation of the ferrous iron.	Water	127-132	ceruloplasmin	Homo sapiens	82-95
26301920-6	2015	The SP size increased with the increase in Ibu-CD2 concentration in pure water.	Water	73-78	CD2 molecule	Homo sapiens	47-50
11972040-5	2002	The structural model suggests that water molecules, which were observed in the vicinity of highly conserved residues and in the retinal pocket, regulate the activity of rhodopsin-like GPCRs and spectral tuning in visual pigments, respectively.	Water	35-40	rhodopsin	Bos taurus	169-178
25924886-1	2015	Small and large PEGs greatly increase chemical potentials of globular proteins (mu2), thereby favoring precipitation, crystallization, and protein-protein interactions that reduce water-accessible protein surface and/or protein-PEG excluded volume.	Water	180-185	progestagen associated endometrial protein	Homo sapiens	16-19
12013227-3	2002	OCOD and structurally related compounds can also be distinguished from these opioids by their absorbance spectra at low wavelengths and via a characteristic neutral H2O loss at the MS2 level.	Water	165-168	MS2	Homo sapiens	181-184
11583816-11	2001	These findings suggest that JNK1 induces apoptotic cell death in response to H(2)O(2), and that the cell death may be involved in the phosphorylations of 55, 72, and 78 kDa proteins induced by JNK1 activation.	Water	77-82	mitogen-activated protein kinase 8	Rattus norvegicus	28-32
26231231-2	2015	On the other hand, aquaporin (AQP) 3, a member of a subgroup of the aquaporin family that transports both water and small solutes, such as glycerol, has been documented to play an important role in the skin homeostasis.	Water	106-111	aquaporin 3 (Gill blood group)	Rattus norvegicus	19-36
11563913-2	2001	The dependence of BSSL on bile acids for activity with water-insoluble substrates differentiates it from other lipases.	Water	55-60	carboxyl ester lipase	Homo sapiens	18-22
11495689-5	2001	In the water-deprived and polyethylene glycol-treated rats, heart particulate prolyl endopeptidase was lower than in the control rats.	Water	7-12	prolyl endopeptidase	Rattus norvegicus	78-98
11495689-6	2001	Particulate prolyl endopeptidase was also lower in the adrenal gland of the acute salt-loaded rats and in the brain cortex of the water-loaded rats than in the control rats.	Water	130-135	prolyl endopeptidase	Rattus norvegicus	12-32
12036059-6	2002	The results showed that dehydrogenation occurred randomly at the positions where hydroxyl groups are attached, but the most preferred position was C-3 and the radical position moved from C-3 to C-4 by the elimination of water molecule.	Water	220-225	complement C4A (Rodgers blood group)	Homo sapiens	194-197
11918716-9	2002	By stopped-flow light scattering, keratinocyte plasma membranes, where aquaporin-3 is localized, exhibited a high, pH-sensitive, water permeability.	Water	129-134	aquaporin 3 (Gill blood group)	Homo sapiens	71-82
11918716-12	2002	Our results suggest that the human epidermis, below the stratum corneum, exhibits a high, aquaporin-3-mediated, water permeability.	Water	112-117	aquaporin 3 (Gill blood group)	Homo sapiens	90-101
11495689-7	2001	Data suggest that tissue-dependent peptide hydrolysis evoked by prolyl endopeptidase activity is involved in the water-electrolyte homeostasis.	Water	113-118	prolyl endopeptidase	Rattus norvegicus	64-84
25451797-1	2015	Astroglial inward rectifying Kir4.1 potassium channels are fundamental for the maintenance of ion and water homeostasis in the central nervous system (CNS).	Water	102-107	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	29-35
11758790-0	2001	Water modulation of stratum corneum chymotryptic enzyme activity and desquamation.	Water	0-5	kallikrein related peptidase 7	Homo sapiens	20-55
11918716-13	2002	We propose that the role of aquaporin-3 is to water-clamp viable layers of the epidermis in order to improve the hydration of the epidermis below the stratum corneum.	Water	46-51	aquaporin 3 (Gill blood group)	Homo sapiens	28-39
11758790-2	2001	We hypothesized that by modulating the water content of the stratum corneum in the surface layers, RH effects the rate of desquamation by modulating the activity of the desquamatory enzymes, and specifically stratum corneum chymotryptic enzyme (SCCE).	Water	39-44	kallikrein related peptidase 7	Homo sapiens	208-243
26196359-0	2015	Fabrication of hierarchical ZnO/CdS heterostructured nanocomposites for enhanced hydrogen evolution from solar water splitting.	Water	111-116	CDP-diacylglycerol synthase 1	Homo sapiens	32-35
11758790-2	2001	We hypothesized that by modulating the water content of the stratum corneum in the surface layers, RH effects the rate of desquamation by modulating the activity of the desquamatory enzymes, and specifically stratum corneum chymotryptic enzyme (SCCE).	Water	39-44	kallikrein related peptidase 7	Homo sapiens	245-249
12062383-2	2002	Molecular dynamics simulations were carried out on pure water and an aqueous solution of myoglobin to determine the spatial distribution of water molecules in each of them.	Water	140-145	myoglobin	Homo sapiens	89-98
26550426-1	2015	OBJECTIVE: To improve the water solubility of glaucocalyxin A (GLA) by the preparation of glaucocalyxin A gamma-cyclodextrin clathrate (GLA-gamma-CD) and to investigate the inhibitory effect of GLA-gamma-CD on tumor growth in S180 cell xenografts.	Water	26-31	galactosidase, alpha	Mus musculus	63-66
11902895-2	2002	Fe(OH)CrL(H(2)O)(6) and Al(OH)CrL(H(2)O)(6) are binuclear complexes, the metals ions being bridged via oxygen atoms.	Water	10-15	interleukin 31 receptor A	Homo sapiens	6-9
11558333-4	2001	All peroxidase activities are increased by salt stress, the water-soluble peroxidase activity being increased much more in the salt-sensitive than in the salt-tolerant species, while the opposite result is observed with the cell-wall peroxidase activity.	Water	60-65	peroxidase-like	Triticum aestivum	4-14
11558333-4	2001	All peroxidase activities are increased by salt stress, the water-soluble peroxidase activity being increased much more in the salt-sensitive than in the salt-tolerant species, while the opposite result is observed with the cell-wall peroxidase activity.	Water	60-65	peroxidase-like	Triticum aestivum	74-84
11558333-4	2001	All peroxidase activities are increased by salt stress, the water-soluble peroxidase activity being increased much more in the salt-sensitive than in the salt-tolerant species, while the opposite result is observed with the cell-wall peroxidase activity.	Water	60-65	peroxidase-like	Triticum aestivum	74-84
11902895-2	2002	Fe(OH)CrL(H(2)O)(6) and Al(OH)CrL(H(2)O)(6) are binuclear complexes, the metals ions being bridged via oxygen atoms.	Water	34-39	interleukin 31 receptor A	Homo sapiens	30-33
25935279-6	2015	With the improved visible light degradation performance, these CdS/TiO2 heteronanofibers would be expected to be used in water purification.	Water	121-126	CDP-diacylglycerol synthase 1	Homo sapiens	63-66
11861807-8	2002	A water-soluble analog of arvanil, O-2142, was as active on VR1, much less active on AMT and CB1, and more potent on FAAH.	Water	2-7	fatty acid amide hydrolase	Mus musculus	117-121
11577868-1	2001	The soil organic partition coefficient (Koc) is one of the most important parameters to depict the transfer and fate of a chemical in the soil-water system.	Water	143-148	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	40-43
11577868-8	2001	The smaller the (symbol in text), the higher the r. Therefore, it is recommended that the eluent of smaller (symbol in text), such as water, be used for accurately estimating Koc.	Water	134-139	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	175-178
26159036-3	2015	Several complexes of HCOOH/CO/H2O and HCOOH/CO2 composition have been characterized in B3LYP and MP2 calculations.	Water	30-33	tryptase pseudogene 1	Homo sapiens	97-100
11597198-0	2001	Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta.	Water	0-5	aquaporin 3 (Gill blood group)	Homo sapiens	23-27
11597198-5	2001	Since AQP3 is not only a water channels, but also permits the rapid passage of both urea and glycerol, while AQP9 also mediates the passage of carbamides, polyols, purines, and pyrimidines, we have speculated that these proteins could be involved in the transport of water and solutes from mother to fetus.	Water	25-30	aquaporin 3 (Gill blood group)	Homo sapiens	6-10
26171978-4	2015	By virtue of their unique porous nanotube structure and cosensitization effect, the ZnO/CdS/CdSe porous NTAs show superior photoelectrochemical water-splitting performance and organic-pollutant-degradation ability under visible light irradiation, as well as excellent long-term photostability.	Water	144-149	CDP-diacylglycerol synthase 1	Homo sapiens	88-91
11597198-5	2001	Since AQP3 is not only a water channels, but also permits the rapid passage of both urea and glycerol, while AQP9 also mediates the passage of carbamides, polyols, purines, and pyrimidines, we have speculated that these proteins could be involved in the transport of water and solutes from mother to fetus.	Water	267-272	aquaporin 3 (Gill blood group)	Homo sapiens	6-10
11748229-7	2002	Because Cys(501) is accessible for modification by the membrane-impermeant reagent pCMPS, we hypothesize that eNTPDase3 (and possibly other eNTPDases) contains a water-filled crevice allowing access of water and hydrophilic compounds to at least part of the protein"s C-terminal membrane-spanning helix.	Water	162-167	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	110-119
11748229-7	2002	Because Cys(501) is accessible for modification by the membrane-impermeant reagent pCMPS, we hypothesize that eNTPDase3 (and possibly other eNTPDases) contains a water-filled crevice allowing access of water and hydrophilic compounds to at least part of the protein"s C-terminal membrane-spanning helix.	Water	202-207	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	110-119
11829651-4	2002	The result implies that the T(21) time constant mainly is determined by the structure of the myofilament lattice and so strongly supports a previously proposed theory that the T(21) population corresponds to water located within a highly organized myofibrillar protein matrix including actin and myosin filament structures.	Water	208-213	myosin heavy chain 14	Homo sapiens	296-302
11879237-3	2002	The MARS technology has been shown to remove water-soluble and albumin-bound toxins and to provide renal support in case of renal failure.	Water	45-50	methionyl-tRNA synthetase 1	Homo sapiens	4-8
11806943-7	2002	Analytical characterization of water-permeable volumes in x-ray-derived bound and free antithrombin structures were correlated with the volumes measured in solution.	Water	31-36	serpin family C member 1	Homo sapiens	87-99
11826172-1	2002	Arginine vasopressin (AVP) regulates the osmotic water permeability of the kidney collecting duct by inducing exocytotic insertion of aquaporin-2 into apical membrane.	Water	49-54	aquaporin 2	Rattus norvegicus	134-145
11857925-3	2002	The latter is the mutations of aquaporin-2(AQP-2) water channel, which have had 11 mutations.	Water	50-55	aquaporin 2	Homo sapiens	31-42
11857925-3	2002	The latter is the mutations of aquaporin-2(AQP-2) water channel, which have had 11 mutations.	Water	50-55	aquaporin 2	Homo sapiens	43-48
11857925-9	2002	The mutated AQP-2 should functionally produce water permeability, if it could be routed into plasma membrane.	Water	46-51	aquaporin 2	Homo sapiens	12-17
11993120-3	2002	Degradation of LAS was studied in the water and soil mediums by using laboratory incubation.	Water	38-43	lipoic acid synthetase	Homo sapiens	15-18
11914159-3	2002	The purpose of the present study was to determine if TEA blocks osmotic water flux of native AQP1 channels in kidney, and recombinant AQP1 channels expressed in a kidney derived MDCK cell line.	Water	72-77	aquaporin-1	Canis lupus familiaris	93-97
11805129-5	2002	As a result, Dgat(-/-) mice had impaired water repulsion and defective thermoregulation after water immersion.	Water	41-46	diacylglycerol O-acyltransferase 1	Mus musculus	13-17
12708079-7	2002	Pdi at rest was 8.4 +/- 2.6 cm H2O.	Water	31-34	peptidyl arginine deiminase 1	Homo sapiens	0-3
11677228-1	2001	Measurement of water transfer during antithrombin activation by heparin.	Water	15-20	serpin family C member 1	Homo sapiens	37-49
11677228-4	2001	We investigated water-transfer reactions during the activation process to explore the possibility that functional interaction between antithrombin and sulfated glycosaminoglycans can be regulated by osmotic potentials.	Water	16-21	serpin family C member 1	Homo sapiens	134-146
11677228-6	2001	Osmotic stress was induced with chemically inert probes that are geometrically excluded from the water-permeable spaces of antithrombin and from intermolecular spaces formed during the association reaction.	Water	97-102	serpin family C member 1	Homo sapiens	123-135
11677228-11	2001	Analytical characterization of water-permeable volumes in x-ray-derived bound and free antithrombin structures revealed complex surfaces with smaller hydration volumes in the bound relative to the free conformation.	Water	31-36	serpin family C member 1	Homo sapiens	87-99
11721009-3	2001	In our previous study, we have clarified the mechanism of the GTP--&gt;GDP hydrolysis reaction in the wild-type p21(ras) at the atomic level and concluded that GTPase-activating protein plays a significant role in the supply of H2O molecules for the hydrolysis.	Water	228-231	H3 histone pseudogene 16	Homo sapiens	112-115
11811445-5	2001	Increasing water sulfate concentration resulted in linear decreases in ADG (P &lt; 0.01) and gain:feed ratio (P &lt; 0.01) and a quadratic effect on water intake (P = 0.02) and tended to quadratically increase then decrease DMI (P = 0.13).	Water	11-16	ADG	Bos taurus	71-74
11811445-13	2001	However, toward the latter stages of the trial, cattle supplied higher-sulfate water had higher ADG and FE.	Water	79-84	ADG	Bos taurus	96-99
11798017-2	2001	Leu-enkephalin amide was successfully synthesized in water by the solid phase method using this protecting group.	Water	53-58	prodynorphin	Homo sapiens	0-14
11741631-2	2001	Since aquaporin 5 is involved in transport of water and is present in salivary and lacrimal glands, this protein was thought to have a major role in the pathogenesis of PSS.	Water	46-51	aquaporin 5	Homo sapiens	6-17
11793119-3	2001	Mutations in the aquaporin-2 (AQP2) water channel gene are responsible for the autosomal recessive and rare dominant forms of NDI.	Water	36-41	aquaporin 2	Homo sapiens	17-28
11793119-3	2001	Mutations in the aquaporin-2 (AQP2) water channel gene are responsible for the autosomal recessive and rare dominant forms of NDI.	Water	36-41	aquaporin 2	Homo sapiens	30-34
11752387-11	2001	Germination and seedling establishment were compromised in the myb61 and ttg1-1 mutants under conditions of reduced water potential, suggesting a function for Arabidopsis seed mucilage during germination in dry conditions.	Water	116-121	myb domain protein 61	Arabidopsis thaliana	63-68
12240153-1	2001	The complex [(PPh3)Ag(CB11H6Br6)] 1 is an effective and selective catalyst (0.1 mol% loading) for a hetero-Diels-Alder reaction, which shows a marked dependence on the presence of trace amounts of water, while addition of Ag[Y] [Y = CB11H12, CB11H6Br6, O3SCF3] to a phosphine functionalized support gives an efficient and recyclable Lewis acid catalyst for this transformation.	Water	197-202	protein phosphatase 4 catalytic subunit	Homo sapiens	14-18
11721893-3	2001	Images of MEH-PPV were obtained with comparable spatial resolution in both air and water.	Water	83-88	epoxide hydrolase 1	Homo sapiens	10-13
11606291-3	2001	The result of QM calculations suggested that the ATP hydrolysis mechanism of myosin consists of a single elementary reaction in which a water molecule nucleophilically attacked gamma-phosphorus of ATP.	Water	136-141	myosin heavy chain 14	Homo sapiens	77-83
11700274-8	2001	However, 26 of 27 water-rinse samples gave a result for two genes, albumin and CYP1A1, using real-time PCR methods.	Water	18-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	79-85
11788052-3	2001	In these same mice, Abeta vaccinations had no deleterious behavioral effects and, in fact, benefited the mice by providing partial protection from age-related deficits in spatial working memory in the radial arm water maze task (RAWM) at 15.5 months.	Water	212-217	amyloid beta (A4) precursor protein	Mus musculus	20-25
11673990-2	2001	The structures of Co4(SO4)(OH)6(C2N2H8)0.5*3H2O and Co4(SO4)(OH)6(C6N2H12)0.5*H2O and their thermal stability can be tailored via the choice of organic pillar.	Water	44-47	complement C4A (Rodgers blood group)	Homo sapiens	18-21
11673998-1	2001	The structure and energy properties of the 1:1 complexes formed between cyanoacetylene and H2O (D2O) are investigated using FT-IR matrix isolation spectroscopy and ab initio calculations at the MP2/ 6-31G(d,p) level.	Water	91-94	tryptase pseudogene 1	Homo sapiens	194-197
11557632-3	2001	Intra-Acb shell amylin infusions decreased ambulation, rearing, feeding, and drinking in either food-deprived rats or water-deprived rats; motor activity was affected more potently than ingestive behavior.	Water	118-123	islet amyloid polypeptide	Rattus norvegicus	16-22
11557632-4	2001	Moreover, intra-Acb shell amylin reduced motor activity in nondeprived rats tested in the absence of food or water, indicating that the expression of amylin"s effects is independent of drive or proximal incentives.	Water	109-114	islet amyloid polypeptide	Rattus norvegicus	26-32
11557632-5	2001	Intra-Acb core amylin infusions in water-deprived rats also decreased ambulation and water intake, although anterior Acb placements were associated with smaller motor effects, regardless of Acb subregion.	Water	35-40	islet amyloid polypeptide	Rattus norvegicus	15-21
11557632-5	2001	Intra-Acb core amylin infusions in water-deprived rats also decreased ambulation and water intake, although anterior Acb placements were associated with smaller motor effects, regardless of Acb subregion.	Water	85-90	islet amyloid polypeptide	Rattus norvegicus	15-21
11729671-4	2001	Upregulation of IEG and HSP70 mRNAs were observed in the smooth muscle cells of muscularis mucosae, muscularis externa and blood vessels in response to water immersion-restraint stress or intragastric application of absolute ethanol.	Water	152-157	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	24-29
11758790-8	2001	Since SCCE, a water-requiring enzyme, must function in the water-depleted outer stratum corneum, we sought to determine whether this enzyme has a tolerance to lowered water activity.	Water	14-19	kallikrein related peptidase 7	Homo sapiens	6-10
11758790-8	2001	Since SCCE, a water-requiring enzyme, must function in the water-depleted outer stratum corneum, we sought to determine whether this enzyme has a tolerance to lowered water activity.	Water	59-64	kallikrein related peptidase 7	Homo sapiens	6-10
11758790-8	2001	Since SCCE, a water-requiring enzyme, must function in the water-depleted outer stratum corneum, we sought to determine whether this enzyme has a tolerance to lowered water activity.	Water	59-64	kallikrein related peptidase 7	Homo sapiens	6-10
11758790-9	2001	Using concentrated sucrose solutions to lower water activity, we analysed the activity of recombinant SCCE and compared it to that of trypsin and chymotrypsin.	Water	46-51	kallikrein related peptidase 7	Homo sapiens	102-106
11758790-10	2001	SCCE activity demonstrated a tolerance to water restriction, and this may be an adaptation to maintain enzyme activity even within the water-depleted stratum corneum intercellular space.	Water	42-47	kallikrein related peptidase 7	Homo sapiens	0-4
11532454-1	2001	The homotetrameric aquaporin-2 (AQP2) water channel is essential for the concentration of urine and of critical importance in diseases with water dysregulation, such as nephrogenic diabetes insipidus, congestive heart failure, liver cirrhosis and pre-eclampsia.	Water	38-43	aquaporin 2	Homo sapiens	19-30
11532454-1	2001	The homotetrameric aquaporin-2 (AQP2) water channel is essential for the concentration of urine and of critical importance in diseases with water dysregulation, such as nephrogenic diabetes insipidus, congestive heart failure, liver cirrhosis and pre-eclampsia.	Water	38-43	aquaporin 2	Homo sapiens	32-36
11532454-1	2001	The homotetrameric aquaporin-2 (AQP2) water channel is essential for the concentration of urine and of critical importance in diseases with water dysregulation, such as nephrogenic diabetes insipidus, congestive heart failure, liver cirrhosis and pre-eclampsia.	Water	140-145	aquaporin 2	Homo sapiens	19-30
11532454-1	2001	The homotetrameric aquaporin-2 (AQP2) water channel is essential for the concentration of urine and of critical importance in diseases with water dysregulation, such as nephrogenic diabetes insipidus, congestive heart failure, liver cirrhosis and pre-eclampsia.	Water	140-145	aquaporin 2	Homo sapiens	32-36
11532454-5	2001	HT-AQP2 had retained its homotetrameric structure and exhibited a single channel water permeability of 0.93+/-0.03x10(-13) cm3/s, similar to that of other AQPs.	Water	81-86	aquaporin 2	Homo sapiens	0-7
11489328-0	2001	Cell type specific and glucose responsive expression of interleukin-4 by using insulin promoter and water soluble lipopolymer.	Water	100-105	interleukin 4	Mus musculus	56-69
11500900-0	2001	Chemical Involvement of Solvent Water Molecules in Elementary Steps of the Fenton Oxidation Reaction We gratefully acknowledge the helpful discussions with Michiel Gribnau (Unilever-Vlaardingen) and we thank the Netherlands Organization for Scientific Research (NWO) for support through the PPM-CMS program and the NCF for providing computer time.	Water	32-37	neutrophil cytosolic factor 4	Homo sapiens	315-318
11468383-1	2001	Crystals adopt the uncommon space group P4(2)/ncm and display a complex set of intermolecular interactions in which the water molecules play the crucial role: the water O-atom [O2(w)] accepts two hydrogen bonds and both water H atoms act as bifurcated donors.	Water	163-168	CWC22 spliceosome associated protein homolog	Homo sapiens	46-49
11466355-3	2001	Because B cells present exogenous Ags and superantigens (SAgs), and medullary thymic epithelial cells are specialized APC for self Ags during negative selection in the thymus, we have hypothesized that H2-O might play a role in MHC class II-restricted SAg and self Ag presentation.	Water	202-206	S-antigen visual arrestin	Homo sapiens	57-60
11466355-4	2001	In this study, we demonstrate that H2-O expression inhibits presentation of the bacterial SAgs staphylococcal enterotoxins A and B to four SAg-reactive T hybridoma cells.	Water	35-39	S-antigen visual arrestin	Homo sapiens	90-93
11466355-7	2001	These data suggest H2-O may have a physiological role in tolerance induction and SAg-mediated toxic shock.	Water	19-23	S-antigen visual arrestin	Homo sapiens	81-84
11481402-1	2001	Water-extracted Touchi, a traditional Chinese food, exerts a strong inhibitory activity against rat intestinal alpha-glucosidase in foodstuffs, and Touchi-extract (TE) has been shown to have an antihyperglycemic effect in rats and humans after a single oral administration.	Water	0-5	sucrase-isomaltase	Homo sapiens	111-128
11473624-1	2001	The antidiuretic hormone arginine vasopressin (AVP) regulates water reabsorption in renal principal cells by inducing a cAMP/protein kinase A-dependent translocation of water channels [aquaporin-2 (AQP2)] from intracellular vesicles into the apical cell membranes.	Water	62-67	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	125-141
11477645-3	2001	Requirements are good gradient selection and selective suppression of CSF in residual water.	Water	86-91	colony stimulating factor 2	Homo sapiens	70-73
11452138-12	2001	In contrast, AR remained perinuclear when treated with water from the control sites (indicating the absence of an AR ligand).	Water	55-60	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	13-15
11457453-1	2001	The ability of ceruloplasmin (Cp) to oxidize low-density lipoproteins (LDL) in the presence of water-soluble antioxidants was investigated and a reaction mechanism proposed.	Water	95-100	ceruloplasmin	Homo sapiens	15-28
11472245-0	2001	Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (zetaalpha(2)(H)).	Water	43-48	plexin A2	Homo sapiens	72-82
11472245-1	2001	We propose a rapid method for the measurement of octanol/water partition coefficients (log P(oct)) via fast gradient reversed phase retention and the calculation of the hydrogen bond acidity of the compounds.	Water	57-62	plexin A2	Homo sapiens	49-52
11408655-3	2001	Stomatal opening in gpa1 plants is insensitive to inhibition by ABA, and the rate of water loss from gpa1 mutants is greater than that from wild-type plants.	Water	85-90	G protein alpha subunit 1	Arabidopsis thaliana	101-105
11352808-3	2001	Heat shock protein 70 (HSP70) expression in rats was induced by a 20-min period of water immersion (42 degrees C).	Water	83-88	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	0-21
11352808-3	2001	Heat shock protein 70 (HSP70) expression in rats was induced by a 20-min period of water immersion (42 degrees C).	Water	83-88	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	23-28
11454023-10	2001	KCC2 located in the same microenvironment may provide a Cl- extrusion mechanism to deal with both ion and water homeostasis in addition to its role in setting the driving force of Cl- currents involved in fast postsynaptic inhibition.	Water	106-111	solute carrier family 12 member 5	Rattus norvegicus	0-4
11455453-1	2001	The intestinal peptides guanylin and uroguanylin regulate the electrolyte/water transport in the gastrointestinal epithelium via activation of cystic fibrosis transmembrane conductance regulator (CFTR), the cystic fibrosis gene product.	Water	74-79	guanylate cyclase activator 2B	Rattus norvegicus	37-48
11455453-1	2001	The intestinal peptides guanylin and uroguanylin regulate the electrolyte/water transport in the gastrointestinal epithelium via activation of cystic fibrosis transmembrane conductance regulator (CFTR), the cystic fibrosis gene product.	Water	74-79	CF transmembrane conductance regulator	Rattus norvegicus	143-194
11455453-1	2001	The intestinal peptides guanylin and uroguanylin regulate the electrolyte/water transport in the gastrointestinal epithelium via activation of cystic fibrosis transmembrane conductance regulator (CFTR), the cystic fibrosis gene product.	Water	74-79	CF transmembrane conductance regulator	Rattus norvegicus	196-200
11455453-7	2001	The expression and cell-specific localization of guanylin and uroguanylin in the salivary glands indicate that these peptides may be specifically involved in the regulation of CFTR-mediated electrolyte/water secretion in the salivary gland ductal system.	Water	202-207	guanylate cyclase activator 2B	Rattus norvegicus	62-73
11455453-7	2001	The expression and cell-specific localization of guanylin and uroguanylin in the salivary glands indicate that these peptides may be specifically involved in the regulation of CFTR-mediated electrolyte/water secretion in the salivary gland ductal system.	Water	202-207	CF transmembrane conductance regulator	Rattus norvegicus	176-180
11382807-1	2001	Several aquaporin-type water channels are expressed in mammalian airways and lung: AQP1 in microvascular endothelia, AQP3 in upper airway epithelia, AQP4 in upper and lower airway epithelia, and AQP5 in alveolar epithelia.	Water	23-28	aquaporin 3 (Gill blood group)	Homo sapiens	117-121
11382807-1	2001	Several aquaporin-type water channels are expressed in mammalian airways and lung: AQP1 in microvascular endothelia, AQP3 in upper airway epithelia, AQP4 in upper and lower airway epithelia, and AQP5 in alveolar epithelia.	Water	23-28	aquaporin 5	Homo sapiens	195-199
11292629-1	2001	Arginine vasopressin (AVP) mediates water transport in the renal collecting ducts by forming water channels of aquaporin-2 (AQP2) in the apical plasma membrane.	Water	36-41	aquaporin 2	Homo sapiens	111-122
11292629-1	2001	Arginine vasopressin (AVP) mediates water transport in the renal collecting ducts by forming water channels of aquaporin-2 (AQP2) in the apical plasma membrane.	Water	36-41	aquaporin 2	Homo sapiens	124-128
11292629-3	2001	We wanted to test the hypothesis that urinary excretion of AQP2 (u-AQP2) reflects the effect of AVP on the renal collecting ducts during water deprivation and hypertonic saline infusion in healthy subjects.	Water	137-142	aquaporin 2	Homo sapiens	59-63
11292629-3	2001	We wanted to test the hypothesis that urinary excretion of AQP2 (u-AQP2) reflects the effect of AVP on the renal collecting ducts during water deprivation and hypertonic saline infusion in healthy subjects.	Water	137-142	aquaporin 2	Homo sapiens	67-71
11708139-4	2001	A quantitative structure-activity relationship was obtained to describe the AA of flavonoids: IC50(microM) = 30.36 + 151.50 E1/2 (V) -12.63 log P (r = 0.852), where IC50 represents the concentration for 50% inhibition of LPO, and P represents the octanol/water partition coefficient.	Water	255-260	small nucleolar RNA, H/ACA box 73A	Homo sapiens	124-132
11507908-0	2001	[UV photolysis mechanism of CCl4 and CHCl3 in water].	Water	46-51	C-C motif chemokine ligand 4	Homo sapiens	28-32
11507908-1	2001	The photolysis mechanism of CCl4 and CHCl3 in water was studied by using transient absorption spectra.	Water	46-51	C-C motif chemokine ligand 4	Homo sapiens	28-32
11378242-1	2001	Doubly transgenic mAPP+mPS1 mice (15-16 months) had impaired cognitive function in a spatial learning and memory task that combined features of a water maze and a radial arm maze.	Water	146-151	presenilin 1	Mus musculus	23-27
11378242-6	2001	These data argue that radial arm water maze testing of doubly transgenic mice may be a useful behavioral endpoint in evaluating the functional consequences of potential AD therapies, especially those designed to reduce Abeta load.	Water	33-38	amyloid beta (A4) precursor protein	Mus musculus	219-224
11154696-3	2001	It has been proposed that in vivo lipase adsorption on oil-water emulsion is mediated by a preformed lipase-colipase-mixed micelle complex.	Water	59-64	lipase G, endothelial type	Rattus norvegicus	34-40
11154696-3	2001	It has been proposed that in vivo lipase adsorption on oil-water emulsion is mediated by a preformed lipase-colipase-mixed micelle complex.	Water	59-64	lipase G, endothelial type	Rattus norvegicus	101-107
11401388-0	2001	Ultrasound-Induced Formation of CdS Nanostructures in Oil-in-Water Microemulsions.	Water	61-66	CDP-diacylglycerol synthase 1	Homo sapiens	32-35
11312747-7	2001	For the 1:1 stoichiometric Ln/alpha-1-[P(2)W(17)O(61)](10-) complexes, the Ln ions are bound to four O atoms of the lacunary polyoxometalate framework in addition to four O atoms from solvent (water) molecules as [(H(2)O)(4)Ln(alpha-1-P(2)W(17)O(61))](7-).	Water	193-198	adrenoceptor alpha 1D	Homo sapiens	30-37
11166539-1	2001	Adsorption and desorption dynamics of lysozyme and beta-casein at the air/water interface were investigated through stress relaxation experiments.	Water	74-79	casein beta	Homo sapiens	51-62
11349819-6	2001	Four water molecules bridging between DHFR and MTX contribute an additional -1.7 kcal mol(-1) stability to the complex.	Water	5-10	dihydrofolate reductase	Homo sapiens	38-42
11228954-1	2001	Ammonia can inhibit the formation of bromate in ozonated drinking water by reacting with free bromine (HOBr/OBr-), an intermediate in bromate formation, to form bromamines.	Water	66-71	leptin receptor	Homo sapiens	104-107
11228965-0	2001	Role of temperature, chlorine, and organic matter in copper corrosion by-product release in soft water.	Water	97-102	POC1 centriolar protein A	Homo sapiens	92-96
11228965-2	2001	Long-term tests (6-8 months) in a synthetic, microbially stable soft tap water confirmed that lower pHs and higher temperatures increased copper release to water.	Water	73-78	POC1 centriolar protein A	Homo sapiens	64-68
11135200-1	2001	Lectin-like function was demonstrated in this study for a novel water-soluble polymer with phenylboronic acid residues (poly (AAPBA-DMAm)), which induced appreciable proliferation of murine spleen lymphocytes with an increased expression of interleukin-2 (IL-2) receptor on their surface.	Water	64-69	interleukin 2	Mus musculus	241-254
11135200-1	2001	Lectin-like function was demonstrated in this study for a novel water-soluble polymer with phenylboronic acid residues (poly (AAPBA-DMAm)), which induced appreciable proliferation of murine spleen lymphocytes with an increased expression of interleukin-2 (IL-2) receptor on their surface.	Water	64-69	interleukin 2	Mus musculus	256-260
11224755-0	2001	Gd3+ complexes with slowly exchanging bound-water molecules may offer advantages in the design of responsive MR agents.	Water	44-49	GRDX	Homo sapiens	0-3
11224755-1	2001	RATIONALE AND OBJECTIVES: Slow water exchange in Gd3+ complexes is generally considered detrimental to their use as MR contrast agents.	Water	31-36	GRDX	Homo sapiens	49-52
11301639-6	2001	RESULTS: Sea water, NaCl, and KCl significantly inhibited the increase of TEWL as compared with deionized water (P &lt; 0.003, P &lt; 0.05, P &lt; 0.05, respectively).	Water	13-18	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	9-12
11301639-7	2001	Sea water and NaCl inhibited the decrease of capacitance as well (P &lt; 0.03, P &lt; 0.01).	Water	4-9	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
11035038-1	2001	Hereditary non-X-linked nephrogenic diabetes insipidus (NDI) is caused by mutations in the aquaporin-2 (AQP2) water channel.	Water	110-115	aquaporin 2	Mus musculus	91-102
11035038-1	2001	Hereditary non-X-linked nephrogenic diabetes insipidus (NDI) is caused by mutations in the aquaporin-2 (AQP2) water channel.	Water	110-115	aquaporin 2	Mus musculus	104-108
11758790-10	2001	SCCE activity demonstrated a tolerance to water restriction, and this may be an adaptation to maintain enzyme activity even within the water-depleted stratum corneum intercellular space.	Water	135-140	kallikrein related peptidase 7	Homo sapiens	0-4
11758790-12	2001	In addition, SCCE may be adapted to function in the water-restricted stratum corneum intercellular space.	Water	52-57	kallikrein related peptidase 7	Homo sapiens	13-17
11517153-7	2001	Supplementing the drinking water with 10% glucose increased beta-galactosidase expression both in the paraventricular nucleus and arcuate nucleus of control mice.	Water	27-32	galactosidase, beta 1	Mus musculus	60-78
11479158-9	2001	In summary, our novel finding of AQP3 in PTECs indicates a role for AQP3 in proximal tubule water reabsorption.	Water	92-97	aquaporin 3 (Gill blood group)	Homo sapiens	33-37
11035038-12	2001	The severe phenotype of the AQP2 mutant mice compared with that of mice lacking kidney water channels AQP1, AQP3, and AQP4 indicates a critical role for AQP2 in neonatal renal function in mice.	Water	87-92	aquaporin 2	Mus musculus	153-157
26369118-2	2015	DOX-conjugated CMDexPEG block copolymer formed nanoparticles in water with sizes less than 100 nm.	Water	64-69	aggrecan	Mus musculus	15-23
11271536-7	2001	The Al-O bond length of Al(ORF)4- is shortest in the sterically congested Al[OC(CF3)3]4- anion-which is stable in H2O and aqueous HNO3 (35 weight%)--and indicates a strong and highly polar Al-O bond that is resistant towards heterolytic alkoxide ion abstraction.	Water	114-117	cortactin binding protein 2	Homo sapiens	27-32
11479158-9	2001	In summary, our novel finding of AQP3 in PTECs indicates a role for AQP3 in proximal tubule water reabsorption.	Water	92-97	aquaporin 3 (Gill blood group)	Homo sapiens	68-72
26983245-1	2015	OBJECTIVE: To observe the regulatory effect of Esculentoside A (EsA) on urination and the expression of AQP2 and AQP4 protein of kidney in water-loaded rats, and to discuss its mechanism of diuresis.	Water	139-144	aquaporin 2	Rattus norvegicus	104-108
11548128-2	2001	IRRAS spectra of beta-casein solutions in H2O and D2O show spectral shifts and derivative-like features not commonly observed in monomolecular layer systems.	Water	42-45	casein beta	Homo sapiens	17-28
26149497-5	2015	Synthesized insulin-polymer conjugates form spheres in water, and the self-assembly behavior could be controlled via thermal control, carbohydrate-protein interaction, and protein denaturation.	Water	55-60	insulin	Bos taurus	12-19
11493345-9	2001	The up-regulation of HSP70 protein expression in the oral mucosa of rats exposed to alkaline water, especially Ca(OH)2 treated rats, may indicate a protective response.	Water	93-98	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	21-26
11514626-5	2001	Cells lacking Stm1 display deficiency in the apoptosis-like cell death process induced by treatment with low concentrations of H(2)O(2).	Water	127-132	Stm1p	Saccharomyces cerevisiae S288C	14-18
11449284-1	2001	Over the past 30 years, the water-generated landforms and landscapes of Mars have been revealed in increasing detail by a succession of spacecraft missions.	Water	28-33	methionyl-tRNA synthetase 1	Homo sapiens	72-76
11449284-2	2001	Recent data from the Mars Global Surveyor mission confirm the view that brief episodes of water-related activity, including glaciation, punctuated the geological history of Mars.	Water	90-95	methionyl-tRNA synthetase 1	Homo sapiens	21-25
11449284-2	2001	Recent data from the Mars Global Surveyor mission confirm the view that brief episodes of water-related activity, including glaciation, punctuated the geological history of Mars.	Water	90-95	methionyl-tRNA synthetase 1	Homo sapiens	173-177
11408278-10	2001	We conclude that AQP3 and AQP5 together may provide a pathway for transcellular osmotic water flow in the formation of the primary saliva.	Water	88-93	aquaporin 3 (Gill blood group)	Homo sapiens	17-21
11408278-10	2001	We conclude that AQP3 and AQP5 together may provide a pathway for transcellular osmotic water flow in the formation of the primary saliva.	Water	88-93	aquaporin 5	Homo sapiens	26-30
11397047-6	2001	The osmotic pressure of HSA1 in water was found to be considerably lower than that of the HSA2 modification.	Water	32-37	olfactory receptor family 5 subfamily AC member 2	Homo sapiens	24-28
11488450-3	2001	The water extract potently inhibited the production of AFM1 by cytochrome P450 (CYP)1A1/2 and slightly reduced AFBO formation by CYP1A1/2, CYP2B1, CYP2C11 and CYP3A1/2 in TCDD-treated rat liver microsomes.	Water	4-9	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	63-87
11488450-3	2001	The water extract potently inhibited the production of AFM1 by cytochrome P450 (CYP)1A1/2 and slightly reduced AFBO formation by CYP1A1/2, CYP2B1, CYP2C11 and CYP3A1/2 in TCDD-treated rat liver microsomes.	Water	4-9	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	129-135
11488450-3	2001	The water extract potently inhibited the production of AFM1 by cytochrome P450 (CYP)1A1/2 and slightly reduced AFBO formation by CYP1A1/2, CYP2B1, CYP2C11 and CYP3A1/2 in TCDD-treated rat liver microsomes.	Water	4-9	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	147-154
11387393-8	2001	Importantly, the Ca(2+) dependence of the catalase-mediated effect was opposite to that of H(2)O(2): catalase had a greater enhancing effect in 2.4 mM Ca(2+) than in 1.5 mM, consistent with enhanced H(2)O(2) generation in higher [Ca(2+)](o).	Water	91-96	catalase	Cavia porcellus	101-109
11516639-1	2001	The water-extracted Touchi, a traditional Chinese food, exerted a strong inhibitory activity against rat intestinal alpha-glucosidase in foodstuffs.	Water	4-9	sucrase-isomaltase	Homo sapiens	116-133
11348144-2	2001	The catalytic efficiency of InCl(3), Yb(OTf)(3), and Sc(OTf)(3) in the azidolysis of alpha,beta-epoxycarboxylic acids has been studied in water and in organic solvents, for comparison using NaN(3) and Me(3)SiN(3) as the source of the azido group.	Water	138-143	POU class 5 homeobox 1	Homo sapiens	37-46
11348144-2	2001	The catalytic efficiency of InCl(3), Yb(OTf)(3), and Sc(OTf)(3) in the azidolysis of alpha,beta-epoxycarboxylic acids has been studied in water and in organic solvents, for comparison using NaN(3) and Me(3)SiN(3) as the source of the azido group.	Water	138-143	POU class 5 homeobox 1	Homo sapiens	53-62
11975794-3	2001	This review examines the roles of central vasopressin synthesis and release and collecting duct vasopressin V2 receptor and aquaporin-2 water channel regulation in water-losing and water-retaining states.	Water	136-141	aquaporin 2	Homo sapiens	124-135
11333357-1	2001	Aquaporin-9 (AQP9) is a new member of the aquaporin family of water-selective channels mainly expressed in liver and testis, presenting the characteristic of also being permeable to various solutes, particularly lactate.	Water	62-67	aquaporin 9	Mus musculus	0-11
11333357-1	2001	Aquaporin-9 (AQP9) is a new member of the aquaporin family of water-selective channels mainly expressed in liver and testis, presenting the characteristic of also being permeable to various solutes, particularly lactate.	Water	62-67	aquaporin 9	Mus musculus	13-17
11333357-7	2001	This AQP9 distribution study in mouse brain suggests a role of AQP9 in water homeostasis in the central nervous system.	Water	71-76	aquaporin 9	Mus musculus	5-9
11333357-7	2001	This AQP9 distribution study in mouse brain suggests a role of AQP9 in water homeostasis in the central nervous system.	Water	71-76	aquaporin 9	Mus musculus	63-67
11320486-4	2001	AQP2 is exclusively expressed in the principal cells of the connecting tubule and collecting duct and is the predominant vasopressin-regulated water channel.	Water	143-148	aquaporin 2	Homo sapiens	0-4
11320486-5	2001	AQP3 and AQP4 are both present in the basolateral plasma membrane of collecting duct principal cells and represent exit pathways for water reabsorbed apically via AQP2.	Water	133-138	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
11320486-5	2001	AQP3 and AQP4 are both present in the basolateral plasma membrane of collecting duct principal cells and represent exit pathways for water reabsorbed apically via AQP2.	Water	133-138	aquaporin 2	Homo sapiens	163-167
11331298-5	2001	Furthermore, H(2)O(2-) or UV-stimulated SAPK activity was higher in mouse embryonic fibroblast (MEF) cells from PS1-null mice than in MEF cells from PS(+/+) mice.	Water	13-18	presenilin 1	Mus musculus	112-115
11462170-6	2001	Peptides of amino acids 65-79 within 57-85 and 149-167 within 136-167 were the smallest in the recoverin sequence, respectively, that could induce severe EAU.	Water	154-157	recoverin	Rattus norvegicus	95-104
11548870-3	2001	Transgene expression, hence elevated GH, was achieved in fetuses and neonates by providing 25 mM ZnSO4 to the drinking water of the dams.	Water	119-124	growth hormone	Mus musculus	37-39
11264724-4	2001	Gal-R1 mRNA was abundant in the SON (and magnocellular PVN) of control rats and levels were increased in these same cells after 4 days of salt-loading (2% NaCl solution as drinking water) or water deprivation.	Water	181-186	galanin receptor 1	Rattus norvegicus	0-6
11264724-4	2001	Gal-R1 mRNA was abundant in the SON (and magnocellular PVN) of control rats and levels were increased in these same cells after 4 days of salt-loading (2% NaCl solution as drinking water) or water deprivation.	Water	191-196	galanin receptor 1	Rattus norvegicus	0-6
11239707-1	2001	Aquaporin-4 (AQP4) is the most abundant water channel in the rat brain.	Water	40-45	aquaporin 4	Rattus norvegicus	0-11
11239707-1	2001	Aquaporin-4 (AQP4) is the most abundant water channel in the rat brain.	Water	40-45	aquaporin 4	Rattus norvegicus	13-17
11171953-4	2001	A typical complex, Co(L(22))(2)(2+) is shown to engage in rapid exchange with a competing ligand L(11) and with another complex, Co(L(22))(2)(2+) in 30% acetonitrile/water at pH 7.0 and 25 degrees C. The exchange in the corresponding Co(III) complexes is shown to be much slower.	Water	166-171	ribosomal protein L22	Homo sapiens	22-27
11171953-4	2001	A typical complex, Co(L(22))(2)(2+) is shown to engage in rapid exchange with a competing ligand L(11) and with another complex, Co(L(22))(2)(2+) in 30% acetonitrile/water at pH 7.0 and 25 degrees C. The exchange in the corresponding Co(III) complexes is shown to be much slower.	Water	166-171	ribosomal protein L22	Homo sapiens	132-137
11168456-8	2001	Five hours after the consumption of six glasses of wine, a dramatic increase occurred of PAI-1 antigen (77 +/- 42 microg L-1 vs. - 5 +/- 10 microg L-1 in the mineral water controls; P &lt; 0.001) and PAI-1 activity (27 +/- 15 U mL-1 vs. - 2 +/- 3 U mL-1 in mineral water controls; P &lt; 0.001).	Water	166-171	serpin family E member 1	Homo sapiens	89-94
11160454-7	2001	GluRepsilon1 mutant mice exhibited an increased spontaneous locomotor activity in a novel environment and an impairment of latent learning in a water-finding task.	Water	144-149	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	0-12
11181969-6	2001	Mutations have been identified in the aquaporin-2 gene (AQP2), which is located in chromosome region 12q13 and codes for the vasopressin-sensitive water channel.	Water	147-152	aquaporin 2	Homo sapiens	38-49
11181969-6	2001	Mutations have been identified in the aquaporin-2 gene (AQP2), which is located in chromosome region 12q13 and codes for the vasopressin-sensitive water channel.	Water	147-152	aquaporin 2	Homo sapiens	56-60
11589620-9	2001	Physiologically the present findings indicate that enhanced expression of ENaC leads to suppression of other Cl(-)channels, such as CFTR and CaCC, thereby preconditioning the endometrium in favour of overall salt and water absorption as observed during embryo implantation.	Water	217-222	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	74-78
11170514-5	2001	The reactivity in water of hex-1-ene-1,3-sultone toward model nucleophiles follows the hard and soft acid and base theory with the hard nucleophiles (primary and secondary amine and phenate) mainly reacting at position 3 by S(N) substitution, and the soft nucleophiles (thiolate and imidazole) mainly reacting at position 2 by a Michael addition reaction.	Water	18-23	exonuclease 1	Homo sapiens	27-32
11424179-10	2001	Additionally, a comparison of the gpt and an endogenous locus, Dlb-1, within the small intestine of chronically treated animals (94 microg/mL ENU in drinking water daily) shows differential accumulation of mutations at the loci during chronic exposure.	Water	158-163	glutamic pyruvic transaminase, soluble	Mus musculus	34-37
11424179-10	2001	Additionally, a comparison of the gpt and an endogenous locus, Dlb-1, within the small intestine of chronically treated animals (94 microg/mL ENU in drinking water daily) shows differential accumulation of mutations at the loci during chronic exposure.	Water	158-163	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	63-68
11499608-6	2001	Thus, the input of dissolved U to the Kali estuary is dominated by sea water.	Water	71-76	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	67-70
11077069-8	2001	Both the degree of 5-HT(1A) receptor activation by 8-OH-DPAT and (-)-pindolol, and its inhibition by spiperone, strongly correlate (r(2): 0.78-0.81) with the octanol/water partition coefficients of the mutated amino acid at position 351 of the G(alphai3) protein.	Water	166-171	5-hydroxytryptamine receptor 1A	Homo sapiens	19-36
26273845-1	2015	This work outlines the synthesis of a non-emissive, cyclometalated Ir(III) complex, Ir(ppy)2(H2O)2(+) (Ir1), which elicits a rapid, long-lived phosphorescent signal when coordinated to a histidine-containing protein immobilized on the surface of a magnetic particle.	Water	93-96	nischarin	Homo sapiens	103-106
11137753-5	2001	These results suggest that AQP4 in the cerebral microvessels is involved in the regulation of water transport between blood and brain.	Water	94-99	aquaporin 4	Rattus norvegicus	27-31
26147297-1	2015	In renal collecting duct (CD) principal cells (PCs), vasopressin (VP) acts through its receptor, V2R, to increase intracellular cAMP leading to phosphorylation and apical membrane accumulation of the water channel aquaporin 2 (AQP2).	Water	200-205	aquaporin 2	Canis lupus familiaris	227-231
11466785-4	2001	The accuracy of the method was demonstrated through the analysis of the intermediate water standard GISP and IAEA water intercomparison materials OH-1, OH-2 and OH-3.	Water	85-90	regenerating family member 4	Homo sapiens	100-104
11392817-4	2001	The low size DNA fragments (0.2, 0.4 and 11.0 kb) were observed only following stress (a 5 min swimming in water bath) by means of alpha-32P-dATP incorporation mediated by TdT reaction.	Water	107-112	deoxynucleotidyltransferase, terminal	Mus musculus	172-175
11517664-0	2001	[Actin-regulated water permeability of two transport channels of plasmodesmata in roots of winter wheat cultivars varying in drought resistance].	Water	17-22	actin-7	Triticum aestivum	1-6
26172322-9	2015	Complexes EYL Ac-Phe-NMe2 and EYL Ac-(Z)-DeltaPhe-NMe2 , stabilized by NH   O or/and CH   O H-bonds were created and optimized at M06-2X/6-31G(d) level of theory in vacuo and in H2 O environment.	Water	178-182	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	50-54
25899674-1	2015	Human guanylin, coded by the GUCA2A gene, is a member of a peptide family that activates intestinal membrane guanylate cyclase, regulating electrolyte and water transport in intestinal and renal epithelia.	Water	155-160	guanylate cyclase activator 2A	Homo sapiens	6-14
11877104-7	2001	Fourth, analyzing "taisu jing lun (Classical Discourses of Taisu)", the commentary of Taisu Shui lun (On water in Comprehensive Notes).	Water	105-110	TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	Homo sapiens	30-33
11877104-7	2001	Fourth, analyzing "taisu jing lun (Classical Discourses of Taisu)", the commentary of Taisu Shui lun (On water in Comprehensive Notes).	Water	105-110	TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	Homo sapiens	97-100
10973964-2	2000	In the renal collecting duct, vasopressin increases osmotic water permeability (P(f)) by triggering trafficking of aquaporin-2 vesicles to the apical plasma membrane.	Water	60-65	aquaporin 2	Homo sapiens	115-126
25899674-1	2015	Human guanylin, coded by the GUCA2A gene, is a member of a peptide family that activates intestinal membrane guanylate cyclase, regulating electrolyte and water transport in intestinal and renal epithelia.	Water	155-160	guanylate cyclase activator 2A	Homo sapiens	29-35
25792480-7	2015	This was linked to photoactivity of CdS that can split H2S resulting in the formation of water in the system.	Water	89-94	CDP-diacylglycerol synthase 1	Homo sapiens	36-39
11086890-7	2000	The water vapor liberated from the lactose particles, was trapped in the molten PEG during the pelletization process.	Water	4-9	progestagen associated endometrial protein	Homo sapiens	80-83
11086890-8	2000	The formation of sub-micron pores was a result of escape of this water vapor on solidification of the molten PEG as well as agglomerate densification.	Water	65-70	progestagen associated endometrial protein	Homo sapiens	109-112
11086893-4	2000	Based on the spatial distribution function (SDF) goo(x,y,z), obtained from the MC simulation in the above conformations in liquid water, the high distribution of hydration water molecules could be divided into hydrogen acceptor (HA), hydrogen donor (HD), MIX (overlapped distribution of HA and HD), and hydrophobic hydration (HH) regions.	Water	172-177	Mix paired-like homeobox	Homo sapiens	255-258
11086893-5	2000	The spatial orientations of hydrogen-bonded water molecules were found to be of a linear type with a triple-layer structure in the HA region and HA part (in the MIX region), and double-layer structures in the HD region and HD part (in the MIX region).	Water	44-49	Mix paired-like homeobox	Homo sapiens	161-164
11086893-5	2000	The spatial orientations of hydrogen-bonded water molecules were found to be of a linear type with a triple-layer structure in the HA region and HA part (in the MIX region), and double-layer structures in the HD region and HD part (in the MIX region).	Water	44-49	Mix paired-like homeobox	Homo sapiens	239-242
11086893-7	2000	From the difference SDF (DSDF), deltagoo(x,y, z), between the SDFs of two conformations, we concluded that the distribution of hydration water molecules in the HA and HD parts of the MIX region are governed by the competition of internal hydrogen bonds between the hydrogen atom and two lone-pair electrons on the oxygen atom of an EG molecule.	Water	137-142	Mix paired-like homeobox	Homo sapiens	183-186
11145096-1	2000	In the kidney, binding of arginine vasopressin to the vasopressin type-2 receptor (V2R) causes redistribution of aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical cell membrane, a process which initiates urine concentration.	Water	132-137	aquaporin 2	Homo sapiens	113-124
11145096-1	2000	In the kidney, binding of arginine vasopressin to the vasopressin type-2 receptor (V2R) causes redistribution of aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical cell membrane, a process which initiates urine concentration.	Water	132-137	aquaporin 2	Homo sapiens	126-130
11131191-11	2000	The fCo(E) values obtained for the LiF powder (3 mm diameter and 15 mm length) irradiated in water, have been applied to the EQUAL external audit network, leading to a good agreement between stated and measured doses, with a mean value of 1.002 +/- 0.022 (1 SD), for 170 beam outputs checked (36 electron beam energies) in 13 "reference" radiotherapy centres in Europe.	Water	93-98	LIF interleukin 6 family cytokine	Homo sapiens	35-38
26039655-1	2015	We report the photochemical generation and study of a family of water-soluble iron(IV)-oxo complexes supported by pentapyridine PY5Me2-X ligands (PY5Me2 = 2,6-bis(1,1-bis(2-pyridyl)ethyl)pyridine; X = CF3, H, Me, or NMe2), in which the oxidative reactivity of these ferryl species correlates with the electronic properties of the axial pyridine ligand.	Water	64-69	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	216-220
11132129-2	2000	It is known that tap water and saltwater baths have a photosensitizing capacity in subsequent UV irradiation of the skin.	Water	21-26	filamin B	Homo sapiens	17-20
11053490-1	2000	Previous studies have established that the vasopressin-regulated water channel of the collecting duct, aquaporin-2, is excreted in the urine, providing a means for assessment of regulation and dysregulation of aquaporin-2 in humans.	Water	65-70	aquaporin 2	Homo sapiens	103-114
11053490-1	2000	Previous studies have established that the vasopressin-regulated water channel of the collecting duct, aquaporin-2, is excreted in the urine, providing a means for assessment of regulation and dysregulation of aquaporin-2 in humans.	Water	65-70	aquaporin 2	Homo sapiens	210-221
26042828-9	2015	In mice, mild water restriction that elevates serum sodium by 5 mmol/l, increased VCAM1, E-selectin and MCP-1 expression in mouse tissues, accelerated atherosclerotic plaque formation in aortic root and caused thickening or walls of coronary arteries.	Water	14-19	vascular cell adhesion molecule 1	Mus musculus	82-87
11046033-6	2000	Although confirmed to be disease free after the initial immunization, both anti-B7- and anti-CD28-treated mice developed severe EAU and elevated cellular responses after the rechallenge, equivalent to those of control mice.	Water	128-131	CD28 antigen	Mus musculus	93-97
11076501-4	2000	Next, water is eliminated between C5 and C6 of dTDP-4-ketoglucose to form dTDP-4-ketoglucose-5,6-ene.	Water	6-11	complement C5	Homo sapiens	34-43
11076974-1	2000	In renal principal cells, vasopressin regulates the shuttling of the aquaporin (AQP)2 water channel between intracellular vesicles and the apical plasma membrane.	Water	86-91	aquaporin 2	Homo sapiens	80-85
25935221-1	2015	CdS quantum dots (CdS QDs) 4.3 nm in diameter synthesized in an AOT/isooctane/water microemulsion and in R-phycoerythrin tunnel cavities (3.5 x 6.0 nm) were analyzed for photoelectrochemical properties.	Water	78-83	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
11073261-7	2000	Addition of even small amounts of two solvents that are less volatile than water, ethylene glycol and 2-methoxyethanol, also results in preferential deprotonation of higher charge state ions of small peptides, but these solvents actually produce an enhancement in the higher charge state ions for both cytochrome c and myoglobin.	Water	75-80	myoglobin	Homo sapiens	319-328
11069123-14	2000	The changes observed in leptin receptor expression in the hypothalamus, along with the suppression of serum leptin levels, also suggest that the leptin signalling system may play a significant role in the regulation of food and water intake during lactation.	Water	228-233	leptin receptor	Rattus norvegicus	24-39
11027237-5	2000	Under water-depleted conditions, c-fos expression was markedly elevated in neurons in the subfornical organ and organum vasculosum laminae terminalis compared with wild-type animals, suggesting a hyperactive state in the Na(v)2-null mice.	Water	6-11	FBJ osteosarcoma oncogene	Mus musculus	33-38
25940738-6	2015	The longer lifetime of [Cp2 Ti(O2 CH)](+) allows for secondary reactions with background water, as a result of which, [Cp2 Ti(OH)](+) is formed.	Water	89-94	ceruloplasmin	Homo sapiens	24-27
11033421-6	2000	(2) Delayed addition of H(2)O(2) to VP-16-treated cells prevents additional caspase induction but does not inhibit the caspase activity that has already been generated.	Water	24-29	caspase 9	Homo sapiens	76-83
11033421-8	2000	(4) Addition of H(2)O(2) to cells inhibits activation of caspase-9, which is required for activation of caspase-3.	Water	16-21	caspase 9	Homo sapiens	57-66
25940738-6	2015	The longer lifetime of [Cp2 Ti(O2 CH)](+) allows for secondary reactions with background water, as a result of which, [Cp2 Ti(OH)](+) is formed.	Water	89-94	ceruloplasmin	Homo sapiens	119-122
26240594-3	2015	AVP increases the osmotic water permeability of the collecting duct cells through aquaporin-2 (AQP2) and aquaporin-3 (AQP3).	Water	26-31	aquaporin 2	Homo sapiens	82-93
11012836-2	2000	In the supraoptic nucleus, the high vascular density may be one element, which together with the water channel aquaporin-4 expressed in the astrocytes, is related to a role in osmoreception.	Water	97-102	aquaporin 4	Rattus norvegicus	111-122
26240594-3	2015	AVP increases the osmotic water permeability of the collecting duct cells through aquaporin-2 (AQP2) and aquaporin-3 (AQP3).	Water	26-31	aquaporin 2	Homo sapiens	95-99
11027521-3	2000	Since iPLA(2) specific inhibitor bromoenollactone almost completely suppressed the release of AA induced by H(2)O(2), we conclude that iPLA(2) activity represents the major mechanism by which H(2)O(2) increases the availability of non-esterified AA in U(III) cells.	Water	108-113	phospholipase A2 group VI	Rattus norvegicus	6-13
26240594-3	2015	AVP increases the osmotic water permeability of the collecting duct cells through aquaporin-2 (AQP2) and aquaporin-3 (AQP3).	Water	26-31	aquaporin 3 (Gill blood group)	Homo sapiens	105-116
11027521-3	2000	Since iPLA(2) specific inhibitor bromoenollactone almost completely suppressed the release of AA induced by H(2)O(2), we conclude that iPLA(2) activity represents the major mechanism by which H(2)O(2) increases the availability of non-esterified AA in U(III) cells.	Water	108-113	phospholipase A2 group VI	Rattus norvegicus	135-142
11027521-4	2000	Moreover, PKC inhibitors sphingosine and calphostin C markedly potentiated the release of AA trigger by H(2)O(2), suggesting a regulatory mechanism of iPLA(2) by PKC that remains to be clarified.	Water	104-109	phospholipase A2 group VI	Rattus norvegicus	151-158
26240594-3	2015	AVP increases the osmotic water permeability of the collecting duct cells through aquaporin-2 (AQP2) and aquaporin-3 (AQP3).	Water	26-31	aquaporin 3 (Gill blood group)	Homo sapiens	118-122
25624241-2	2015	The results showed that compared with tap water (TW) ice, AEW ice had an obvious (p&lt;0.05) capability in limiting the changes of pH and shrinkage of muscle fibers in shrimp.	Water	42-47	filamin B	Homo sapiens	38-41
10978582-1	2000	The recently identified water channel aquaporin 4 is a major component of the orthogonal arrays observed with freeze-fracture electron microscopy.	Water	24-29	aquaporin 4	Rattus norvegicus	38-49
26237833-7	2015	RESULTS: The number of electric-stimulus escapes significantly increased and the Morris water maze test showed prolonged escape latency, greater swimming distance, less time taken to cross the exact former platform location in the model group, and increased mRNA and protein expressions of Beclin-1 and LC3-II compared with the control group (P < 0.05).	Water	88-93	beclin 1, autophagy related	Mus musculus	290-298
11103297-6	2000	The mean fluoride concentrations in drinking water in the three areas were 0.3, 0.6 and 4.0 mgF/L.	Water	45-50	signal transducer and activator of transcription 5A	Homo sapiens	92-95
10942539-0	2000	Incompatibility and Phase Separation in a Bovine Serum Albumin/beta-Casein/Water Ternary Film at the Air-Water Interface.	Water	105-110	casein beta	Homo sapiens	63-74
10942539-2	2000	The incompatibility between BSA and beta-casein at the air-water interface was deduced from deviation of the experimental equilibrium composition of the proteins in the mixed saturated monolayer film from that predicted by the Langmuir-type competitive adsorption model at various bulk concentration ratios.	Water	59-64	casein beta	Homo sapiens	36-47
10997721-10	2000	This response is compatible with blockade of vasopressin V2-receptors in the collecting duct and, as directly demonstrated by immunohistochemistry, subsequent retrieval of aquaporin-2 from apical plasma membrane, which inhibits water permeability and transport.	Water	228-233	aquaporin 2	Rattus norvegicus	172-183
11196777-4	2000	The ratio of H1, 2, and H2, which are present in equilibrium in MeCN solution at 25 degrees C, depends on the concentration of both H+ and H2O.	Water	139-142	H1.5 linker histone, cluster member	Homo sapiens	13-26
10925260-9	2000	Upon stimulation with dendritic cells in the presence of the water-soluble DNFB analogue, DNBS, CTLA-4+ T cells from DNFB-tolerized mice secreted high levels of IL-10, TGF-beta, and IFN-gamma; low levels of IL-2; and no IL-4, resembling the cytokine pattern of T regulatory 1 cells.	Water	61-66	interleukin 2	Mus musculus	207-211
10925260-9	2000	Upon stimulation with dendritic cells in the presence of the water-soluble DNFB analogue, DNBS, CTLA-4+ T cells from DNFB-tolerized mice secreted high levels of IL-10, TGF-beta, and IFN-gamma; low levels of IL-2; and no IL-4, resembling the cytokine pattern of T regulatory 1 cells.	Water	61-66	interleukin 4	Mus musculus	220-224
10818094-9	2000	We propose, by analogy with the diverse crystallins of the eye lens and with the putative enzyme-crystallins (aldehyde dehydrogenase class 3 and other enzymes) of the mammalian cornea, that gelsolin and actin-gelsolin complexes act as water-soluble crystallins in the zebrafish cornea and contribute to its optical properties.	Water	235-240	gelsolin	Homo sapiens	190-198
10818094-9	2000	We propose, by analogy with the diverse crystallins of the eye lens and with the putative enzyme-crystallins (aldehyde dehydrogenase class 3 and other enzymes) of the mammalian cornea, that gelsolin and actin-gelsolin complexes act as water-soluble crystallins in the zebrafish cornea and contribute to its optical properties.	Water	235-240	gelsolin	Homo sapiens	209-217
10919858-6	2000	Complete water restriction of BB rats produced only a small increase in AQP2 mRNA (235 +/- 33%) and AQP2 protein (156 +/- 22%) levels.	Water	9-14	aquaporin 2	Rattus norvegicus	72-76
10919858-6	2000	Complete water restriction of BB rats produced only a small increase in AQP2 mRNA (235 +/- 33%) and AQP2 protein (156 +/- 22%) levels.	Water	9-14	aquaporin 2	Rattus norvegicus	100-104
10931200-12	2000	31P-NMR measurements show that the phosphate geometry has changed in enzyme bound FMN compared to the free flavin in water, indicating a strong interaction of the phosphate group with the apoenzyme.	Water	117-122	formin 1	Homo sapiens	82-85
11009046-17	2000	Furthermore, ibuprofen decreased lithium excretion suggesting that COX-1 is involved in the re-absorption of sodium and/or water in the proximal tubuli.	Water	123-128	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	67-72
10970094-3	2000	Examination of H2-O expression in freshly isolated mouse organs revealed that H2-Oa- and H2-Ob-specific transcripts are present in both lymphoid and nonlymphoid tissues.	Water	15-19	histocompatibility 2, O region alpha locus	Mus musculus	78-83
11028936-6	2000	CONCLUSIONS: The diffusion barrier of water molecules in lyophilized formulations appears to be smaller than the activational barrier of the hydrolysis of aspirin and cephalothin based on the results of this study that the temperature dependence of the hydrolysis rate is almost linear regardless of Tmc and Tg.	Water	38-43	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	300-303
18968032-1	2000	This article presents considerable improvements in SPE-RTP methodology for the analysis of polycyclic aromatic hydrocarbons in water samples.	Water	127-132	MORN repeat containing 4	Homo sapiens	55-58
10773332-1	2000	The granulocyte-macrophage colony stimulating factor (GM-CSF), a water-soluble cytokine, was encapsulated in poly(ethylene carbonate) microspheres (MS) by a double emulsion w(1)/o/w(2) solvent evaporation method.	Water	65-70	colony stimulating factor 2	Homo sapiens	4-52
10773332-1	2000	The granulocyte-macrophage colony stimulating factor (GM-CSF), a water-soluble cytokine, was encapsulated in poly(ethylene carbonate) microspheres (MS) by a double emulsion w(1)/o/w(2) solvent evaporation method.	Water	65-70	colony stimulating factor 2	Homo sapiens	54-60
10827157-8	2000	Functional studies showed that AQP4 accounts for about 15% of total cholangiocyte membrane water permeability.	Water	91-96	aquaporin 4	Rattus norvegicus	31-35
10827157-10	2000	The data suggest that AQP4 facilitates the basolateral transport of water in cholangiocytes, a process that could be relevant to ductal bile formation.	Water	68-73	aquaporin 4	Rattus norvegicus	22-26
10828942-6	2000	Comparison of the structures of free and bound Fab HyHEL-63 reveals that several of the ordered water molecules in the free antibody-combining site are retained and that additional waters are added upon complex formation.	Water	96-101	FA complementation group B	Homo sapiens	47-50
10792048-3	2000	We show that the effector domain is in a polar environment in free MRP, suggesting exposure to water, in agreement with a rod-shaped structure of the protein.	Water	95-100	MARCKS like 1	Homo sapiens	67-70
11051590-4	2000	However, zinc-treated (227 mg/L drinking water) animals resulted in significant normalization of the inhibited AChE activities.	Water	41-46	acetylcholinesterase	Rattus norvegicus	111-115
10773751-0	2000	Water immersion increases urinary excretion of aquaporin-2 in healthy humans.	Water	0-5	aquaporin 2	Homo sapiens	47-58
10773751-1	2000	Many previous studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine and that the excretion increases in response to vasopressin.	Water	84-89	aquaporin 2	Homo sapiens	38-49
10773751-1	2000	Many previous studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine and that the excretion increases in response to vasopressin.	Water	84-89	aquaporin 2	Homo sapiens	51-55
10773751-8	2000	These findings demonstrate that heat-out water immersion stimulates urinary excretion of AQP2 in absence of an increase in plasma AVP.	Water	41-46	aquaporin 2	Homo sapiens	89-93
10753923-0	2000	Molecular cloning and characterization of a novel chloride intracellular channel-related protein, parchorin, expressed in water-secreting cells.	Water	122-127	chloride intracellular channel protein 6	Oryctolagus cuniculus	98-107
10753923-10	2000	These results suggest that parchorin generally plays a critical role in water-secreting cells, possibly through the regulation of chloride ion transport.	Water	72-77	chloride intracellular channel protein 6	Oryctolagus cuniculus	27-36
10751223-2	2000	Studies in Sprague-Dawley rats showed that restriction of water intake for 3 days results in upregulation of urea transporter (UT) mRNA in the inner stripe of outer medulla of the kidney (2.9-kb UT2) but not in the inner medulla (4.0-kb UT1).	Water	58-63	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	195-198
11061268-2	2000	CSF opening pressure between 350 and 500 mm H2O (mean 400 mm H2O) was promptly reduced by 80 to 200 mm H2O (mean reduction, 139 mm H2O) for at least 10 minutes in all patients after IV administration of 50 mg indomethacin.	Water	44-47	colony stimulating factor 2	Homo sapiens	0-3
11061268-2	2000	CSF opening pressure between 350 and 500 mm H2O (mean 400 mm H2O) was promptly reduced by 80 to 200 mm H2O (mean reduction, 139 mm H2O) for at least 10 minutes in all patients after IV administration of 50 mg indomethacin.	Water	61-64	colony stimulating factor 2	Homo sapiens	0-3
11061268-2	2000	CSF opening pressure between 350 and 500 mm H2O (mean 400 mm H2O) was promptly reduced by 80 to 200 mm H2O (mean reduction, 139 mm H2O) for at least 10 minutes in all patients after IV administration of 50 mg indomethacin.	Water	61-64	colony stimulating factor 2	Homo sapiens	0-3
11061268-2	2000	CSF opening pressure between 350 and 500 mm H2O (mean 400 mm H2O) was promptly reduced by 80 to 200 mm H2O (mean reduction, 139 mm H2O) for at least 10 minutes in all patients after IV administration of 50 mg indomethacin.	Water	61-64	colony stimulating factor 2	Homo sapiens	0-3
10751223-7	2000	Our studies reveal the role of vasopressin in long-term regulation of UT1 and UT2 expression during water restriction.	Water	100-105	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	78-81
25201550-11	2015	We propose that LIUS reduces the AQP4 localization around the astrocytic foot processes thereby decreasing water permeability into the brain tissue.	Water	107-112	aquaporin 4	Rattus norvegicus	33-37
10836612-12	2000	Sodium azide, L-ascorbic acid and Trolox (a water-soluble vitamin E) prevented both the UVA1- and the tobacco-induced alteration of MMP-1.	Water	44-49	metalloendoproteinase 2-MMP-like	Nicotiana tabacum	132-137
11354308-4	2000	Water-soluble organotellurium compounds of the diaryl telluride, alkyl aryl telluride and dialkyl telluride type, carrying sulfopropyl groups, were found to be the most efficient tellurium-based inhibitors of thioredoxin reductase ever tested.	Water	0-5	peroxiredoxin 5	Homo sapiens	209-230
11033232-4	2000	These results show that aluminum has a distinct effect on ALA-D activity: first, at relatively lower concentrations it activated, and at high concentration it inhibited, blood ALA-D in vitro; second, it activated the enzyme when administered to drinking water.	Water	254-259	aminolevulinate, delta-, dehydratase	Mus musculus	58-63
25863370-1	2015	Electrochemical oxidation of adsorbed benzo(a)pyrene (BaP) on the glassy carbon electrode (GCE) was explored in acetonitrile-water.	Water	125-130	prohibitin 2	Homo sapiens	54-57
10998256-1	2000	Class I major histocompatibility complex (MHC) heterodimer, composed of human leukocyte antigen (HLA)-A2 heavy chain and human beta(2)-microglobulin (beta(2)m), was produced by denaturation and gel filtration of the recombinant water-soluble HLA-A2/beta(2)m/peptide ternary complex in 8 M urea Tris-HCl buffer, followed by refolding of the separated chains without peptide.	Water	228-233	beta-2-microglobulin	Homo sapiens	150-158
10722699-8	2000	In addition, overexpression of thioredoxin restored glucocorticoid receptor action on the alpha-ENaC GRE in the presence of exogenous H(2)O(2).	Water	134-139	thioredoxin	Homo sapiens	31-42
10751722-0	2000	Identification of mutagenic heterocyclic amines (IQ, Trp-P-1 and AalphaC) in the water of the Danube river.	Water	81-86	polycystin 1, transient receptor potential channel interacting	Homo sapiens	53-72
10710544-1	2000	Vasopression-induced phosphorylation of serine 256 of the aquaporin-2 (AQP2) water channel triggers translocation of the protein from cystolic reservoir vesicles to the apical membrane of collecting duct principal cells.	Water	77-82	aquaporin 2	Rattus norvegicus	58-69
10710544-1	2000	Vasopression-induced phosphorylation of serine 256 of the aquaporin-2 (AQP2) water channel triggers translocation of the protein from cystolic reservoir vesicles to the apical membrane of collecting duct principal cells.	Water	77-82	aquaporin 2	Rattus norvegicus	71-75
10966929-7	2000	One hour after the water load, the expressions of AQP2 mRNA and protein were significantly reduced in the control rats, but they remained unchanged in the glucocorticoid-deficient rats.	Water	19-24	aquaporin 2	Rattus norvegicus	50-54
25863370-2	2015	When the GCE was incubated in 100 nM BaP acetonitrile-water (V(water):V(acetonitrile)=1:1) for 10 min at open circuit, and then transferred into blank acetonitrile-water (V(water):V(acetonitrile)=1:1, pH= 0.70) for differential pulse voltammetry measurement, a distinct oxidation peak at 0.98 V (vs. Ag/AgCl) was observed.	Water	54-59	prohibitin 2	Homo sapiens	37-40
25863370-5	2015	The effects of water on BaP preconcentration on the electrode and electrochemical oxidation were revealed, respectively.	Water	15-20	prohibitin 2	Homo sapiens	24-27
10766399-7	2000	In addition, exaggerated urinary excretion of AQP-2 persisted after an acute water load in patients with impaired water excretion.	Water	77-82	aquaporin 2	Homo sapiens	46-51
26023728-0	2015	Arctic cyclone water vapor isotopes support past sea ice retreat recorded in Greenland ice.	Water	15-20	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	49-52
10720080-8	2000	These results suggest that placental 11beta-HSD2 is involved in not only regulating the passage of maternal active glucocorticoids into the fetal circulation but also in regulation of maternal-fetal electrolyte and water transport in the placenta, as in other mineralocorticoid target organs.	Water	215-220	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	37-48
10942586-4	2000	EF-1alpha protein levels undergo rapid increase upon treatment with H(2)O(2); however, whereas sublethal doses of H(2)O(2) stimulate only transient increases of EF-1alpha protein levels, lethal doses produce sustained elevation of EF-1alpha levels.	Water	68-73	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	0-9
10942586-4	2000	EF-1alpha protein levels undergo rapid increase upon treatment with H(2)O(2); however, whereas sublethal doses of H(2)O(2) stimulate only transient increases of EF-1alpha protein levels, lethal doses produce sustained elevation of EF-1alpha levels.	Water	114-119	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	161-170
10942586-4	2000	EF-1alpha protein levels undergo rapid increase upon treatment with H(2)O(2); however, whereas sublethal doses of H(2)O(2) stimulate only transient increases of EF-1alpha protein levels, lethal doses produce sustained elevation of EF-1alpha levels.	Water	114-119	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	161-170
26023728-1	2015	Rapid Arctic warming is associated with important water cycle changes: sea ice loss, increasing atmospheric humidity, permafrost thaw, and water-induced ecosystem changes.	Water	50-55	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	71-74
10669782-2	2000	Here we observed that the presence of either bile salts or a small proportion of water-miscible organic solvents (called activator compounds) considerably enhances the enzymatic activity of HPL on a monomeric solution of tripropionin.	Water	81-86	galectin 1	Homo sapiens	190-193
26023728-7	2015	Thus, measurements of water vapor isotope ratios during an Arctic cyclone provide a critical processed-based explanation, and the first direct confirmation, of relationships previously assumed to govern water isotope ratios during sea ice retreat and increased input of northern ocean moisture into the Arctic water cycle.	Water	22-27	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	231-234
26023728-7	2015	Thus, measurements of water vapor isotope ratios during an Arctic cyclone provide a critical processed-based explanation, and the first direct confirmation, of relationships previously assumed to govern water isotope ratios during sea ice retreat and increased input of northern ocean moisture into the Arctic water cycle.	Water	203-208	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	231-234
25986484-1	2015	BACKGROUND: Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system, which is characterized by autoantibodies directed against the water channel aquaporin-4 (AQP4).	Water	158-163	aquaporin 4	Rattus norvegicus	172-183
10701516-7	2000	Results obtained in external irradiation indicate that these new miniature LiF:Mg,Cu,P dosimeters have good sensitivity (about 1.6 times that of CaSO4:Dy mini-TLDs), homogeneous response within a production batch (mean +/-4%), response stability in water (0.7% of variation in sensitivity after 2 weeks of immersion) and stability in aqueous solutions at different pH.	Water	249-254	LIF interleukin 6 family cytokine	Homo sapiens	75-78
10924110-0	2000	Interruption of the internal water chain of cytochrome f impairs photosynthetic function.	Water	29-34	cytochrome f	Chlamydomonas reinhardtii	44-56
10924110-1	2000	The structure of cytochrome f includes an internal chain of five water molecules and six hydrogen-bonding side chains, which are conserved throughout the phylogenetic range of photosynthetic organisms from higher plants, algae, and cyanobacteria.	Water	65-70	cytochrome f	Chlamydomonas reinhardtii	17-29
10924110-2	2000	The in vivo electron transfer capability of Chlamydomonas reinhardtii cytochrome f was impaired in site-directed mutants of the conserved Asn and Gln residues that form hydrogen bonds with water molecules of the internal chain [Ponamarev, M. V., and Cramer, W. A.	Water	189-194	cytochrome f	Chlamydomonas reinhardtii	70-82
10689963-8	2000	Frit-FAB interface LC-MS allowed the rapid identification of microcystins in cyanobacteria and lake water, and also enabled us to identify microcystins and their metabolites formed in vivo in mouse liver.	Water	100-105	FA complementation group B	Homo sapiens	5-8
25986484-1	2015	BACKGROUND: Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system, which is characterized by autoantibodies directed against the water channel aquaporin-4 (AQP4).	Water	158-163	aquaporin 4	Rattus norvegicus	185-189
10689963-9	2000	Finally, Frit-FAB/LC-MS using selected ion monitoring could be used for quantitative analysis of microcystins in lake water in the low nanogram range.	Water	118-123	FA complementation group B	Homo sapiens	14-17
25902261-11	2015	This study also observed statistically significant higher levels of NTM in chloraminated water than in chlorinated water.	Water	89-94	neurotrimin	Homo sapiens	68-71
10649374-1	2000	An MP2 ab initio study of the interaction between a H(2)O molecule and trans-[Pt(OH)(2)(NH(3))(2)] revealed a HO-H small middle dot small middle dot small middle dotPt(II) hydrogen bond (see picture) with a strong dispersion component (ca.	Water	52-57	tryptase pseudogene 1	Homo sapiens	3-6
10930459-2	2000	Thioredoxin peroxidase, Tsa1p, of the thioredoxin system, was found to be essential for the transcriptional induction of other components of the thioredoxin system, TRX2 (thioredoxin) and TRR1 (thioredoxin reductase), in response to H(2)O(2).	Water	233-238	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	24-29
10930459-2	2000	Thioredoxin peroxidase, Tsa1p, of the thioredoxin system, was found to be essential for the transcriptional induction of other components of the thioredoxin system, TRX2 (thioredoxin) and TRR1 (thioredoxin reductase), in response to H(2)O(2).	Water	233-238	thioredoxin-disulfide reductase TRR1	Saccharomyces cerevisiae S288C	188-192
10958345-7	2000	A first conclusion is that the epithelium of the mammalian rectum is a highly polarized, aquaporin-3-containing, water permeability structure.	Water	113-118	aquaporin 3 (Gill blood group)	Homo sapiens	89-100
10765110-10	2000	Water, sodium and urea excretion rates were increased in all groups infused with Ang-(1-7); after the combination of Ang-(1-7) + EXP 3174, all increases were higher than after every substance alone; however, statistical significance (p&lt;0.05) was reached in sodium excretion values only.	Water	0-5	ANG	Canis lupus familiaris	81-84
25770446-7	2015	The steady-state kinetic model has been proven to successfully predict the destruction of CHCl2I and CHI3 by UV/H2O2 in different water matrices.	Water	130-135	chitinase 1	Homo sapiens	101-105
18475946-0	2000	Interaction of [Rh(2)(O(2)CCH(3))(4)(H(2)O)(2)] and [Rh(2)(O(2)CCH(OH)Ph)(2)(phen)(2)(H(2)O)(2)](O(2)C-CH(OH)Ph)(2) With Sulfhydryl Compounds and Ceruloplasmin.	Water	37-42	ceruloplasmin	Homo sapiens	146-159
26239456-4	2015	In the renal collecting duct, the aquaporin-2 (AQP2) water channel is regulated by sustained elevation of AVP release, and this leads to augmented hydroosmotic action of AVP, that results in exaggerated water retention and dilutional hyponatremia.	Water	53-58	aquaporin 2	Homo sapiens	34-45
10657532-5	1999	Intracerebroventricular administration of antisense oligonucleotide to GC-B mRNA inhibits the night-time water intake in SHR, but not in WKY.	Water	105-110	natriuretic peptide receptor 2	Rattus norvegicus	71-75
10915563-8	2000	Treatment of coelomocytes (labeled with IL-1alpha) with bivalent water-soluble crosslinkers identified a membrane protein of approximately 70 kDa to which IL-1 is specifically crosslinked.	Water	65-70	interleukin 1 alpha	Homo sapiens	40-49
26239456-4	2015	In the renal collecting duct, the aquaporin-2 (AQP2) water channel is regulated by sustained elevation of AVP release, and this leads to augmented hydroosmotic action of AVP, that results in exaggerated water retention and dilutional hyponatremia.	Water	53-58	aquaporin 2	Homo sapiens	47-51
26239456-4	2015	In the renal collecting duct, the aquaporin-2 (AQP2) water channel is regulated by sustained elevation of AVP release, and this leads to augmented hydroosmotic action of AVP, that results in exaggerated water retention and dilutional hyponatremia.	Water	203-208	aquaporin 2	Homo sapiens	34-45
26239456-4	2015	In the renal collecting duct, the aquaporin-2 (AQP2) water channel is regulated by sustained elevation of AVP release, and this leads to augmented hydroosmotic action of AVP, that results in exaggerated water retention and dilutional hyponatremia.	Water	203-208	aquaporin 2	Homo sapiens	47-51
25902004-6	2015	Interestingly, DFT calculations also predict the existence of a [Co(I)(kappa(4)-L)(OH2)](+) species at least transiently, and its formation is consistent with the experimental Pourbaix diagram.	Water	83-87	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	65-70
10869174-2	2000	The structure displays the same folding and detailed features as turnip cytochrome f, including (a) an unusual heme Fe ligation by the alpha-amino group of tyrosine 1, (b) a cluster of lysine residues (proposed docking site of plastocyanin), and (c) the presence of a chain of seven water molecules bound to conserved residues and extending between the heme pocket and K58 and K66 at the lysine cluster.	Water	283-288	cytochrome f	Chlamydomonas reinhardtii	72-84
11776781-7	1999	The patients with initial CSF pressure over 400 mm H2O were 11% and 90% in TBM and CCM.	Water	51-54	colony stimulating factor 2	Homo sapiens	26-29
25902004-8	2015	We propose that this RDS may originate from the slow removal of a solvent ligand in the intermediate [Co(I)(kappa(4)-L)(OH2)](+) in addition to the significant structural reorganization of the metal complex and surrounding solvent resulting in a high free energy of activation.	Water	120-124	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	102-107
10856829-1	2000	It was shown previously that luteinizing hormone-releasing hormone (LHRH) affects the neurohypophysial oxytocin release in water-deprived rats.	Water	123-128	gonadotropin releasing hormone 1	Rattus norvegicus	29-66
10856829-1	2000	It was shown previously that luteinizing hormone-releasing hormone (LHRH) affects the neurohypophysial oxytocin release in water-deprived rats.	Water	123-128	gonadotropin releasing hormone 1	Rattus norvegicus	68-72
10510301-14	1999	The "hydrostatic versus osmotic pressure" approach probed the importance of water in aging, and also revealed that Asp-70 and Glu-197 are the major residues controlling both the dynamics and the structural organization of the water/hydrogen-bond network in the active-site gorge of BuChE.	Water	226-231	butyrylcholinesterase	Homo sapiens	282-287
10856829-5	2000	LHRH significantly enhanced Na(+)- and K(+)-evoked oxytocin release from explants taken from rats drinking tap water, indicating that LHRH could affect the Na(+)/K(+)-dependent depolarization of perikarya of oxytocin neurones.	Water	111-116	gonadotropin releasing hormone 1	Rattus norvegicus	0-4
25910720-1	2015	This study uses a multidisciplinary approach to simulate the spatial and temporal patterns of hydrodynamics and water quality in a thermally stratified reservoir in the southern side of the Mediterranean Sea in response to water withdrawal elevation using the 2D water quality and laterally averaged hydrodynamic model CE-QUAL-W2.	Water	223-228	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	204-207
10856829-5	2000	LHRH significantly enhanced Na(+)- and K(+)-evoked oxytocin release from explants taken from rats drinking tap water, indicating that LHRH could affect the Na(+)/K(+)-dependent depolarization of perikarya of oxytocin neurones.	Water	111-116	gonadotropin releasing hormone 1	Rattus norvegicus	134-138
10928320-6	2000	This review will focus on the role of AQP5 in the movement of water across the apical plasma membrane in relation to the physiology and pathophysiology of salivary glands.	Water	62-67	aquaporin 5	Homo sapiens	38-42
10505682-8	1999	Despite maintenance of significant hypo-osmolality, rats in which escape was subsequently reversed by water restriction reestablished high dDAVP-stimulated kidney levels of AQP-2 after 4 d of water restriction.	Water	102-107	aquaporin 2	Rattus norvegicus	173-178
10505682-8	1999	Despite maintenance of significant hypo-osmolality, rats in which escape was subsequently reversed by water restriction reestablished high dDAVP-stimulated kidney levels of AQP-2 after 4 d of water restriction.	Water	192-197	aquaporin 2	Rattus norvegicus	173-178
10505682-9	1999	In the second study, AQP-2 expression was evaluated in different regions of kidneys from water-loaded rats undergoing escape from antidiuresis.	Water	89-94	aquaporin 2	Rattus norvegicus	21-26
25771396-8	2015	In addition, silibinin-treated APP/PS1 transgenic mice had greater scores in the Morris Water Maze.	Water	88-93	presenilin 1	Mus musculus	35-38
10891592-1	2000	Aquaporin-4 (AQP4) is a member of a water-selective channel aquaporin-family and mainly expressed in the several structures of the brain and in the collecting duct of the kidney.	Water	36-41	aquaporin 4	Rattus norvegicus	0-11
25923432-4	2015	The method is based on our previous findings that the production of Abeta from the interaction between the beta-amyloid precursor protein (APP) and Presenilin (PS), as part of the gamma-secretase complex, in cell culture is largely inhibited if the entire water-soluble NH2-terminal domain of PS is first added to the culture.	Water	256-261	amyloid beta (A4) precursor protein	Mus musculus	68-73
10891592-1	2000	Aquaporin-4 (AQP4) is a member of a water-selective channel aquaporin-family and mainly expressed in the several structures of the brain and in the collecting duct of the kidney.	Water	36-41	aquaporin 4	Rattus norvegicus	13-17
10748162-1	2000	The bradykinin type 2 receptor (BK2) is a developmentally regulated G protein-coupled receptor that mediates diverse actions such as vascular reactivity, salt and water excretion, inflammatory responses, and cell growth.	Water	163-168	bradykinin receptor B2	Homo sapiens	32-35
10583753-2	1999	The Gram-negative, rod-shaped, sulphate-reducing strains MM6, EF2, FM2, and GF2 were isolated from drain water, and from drilling muds E, F, and G, respectively.	Water	105-110	eukaryotic translation elongation factor 2	Homo sapiens	62-65
10548041-9	1999	Under the nanoflow ESI conditions, water molecules appear to be maintained in the Fyn SH2-ligand complex.	Water	35-40	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
25923432-4	2015	The method is based on our previous findings that the production of Abeta from the interaction between the beta-amyloid precursor protein (APP) and Presenilin (PS), as part of the gamma-secretase complex, in cell culture is largely inhibited if the entire water-soluble NH2-terminal domain of PS is first added to the culture.	Water	256-261	amyloid beta (A4) precursor protein	Mus musculus	107-137
25923432-5	2015	Here we demonstrate that two small, non-overlapping water-soluble peptides from the PS-1 NH2-terminal domain can substantially and specifically inhibit the production of total Abeta as well as Abeta40 and 42 in vitro and in vivo in the brains of APP transgenic mice.	Water	52-57	presenilin 1	Mus musculus	84-88
12205959-5	1999	RESULT: A water-soluble polysaccharide with mean molecular weight of 2.47 x 10(14), named Co-4, was obtained.	Water	10-15	complement C4A (Rodgers blood group)	Homo sapiens	90-94
25923432-5	2015	Here we demonstrate that two small, non-overlapping water-soluble peptides from the PS-1 NH2-terminal domain can substantially and specifically inhibit the production of total Abeta as well as Abeta40 and 42 in vitro and in vivo in the brains of APP transgenic mice.	Water	52-57	amyloid beta (A4) precursor protein	Mus musculus	176-181
26574355-2	2015	We evaluated the importance and reliability of small basis set CCSD(T) corrections to MP2 (delta(MP2)(CCSD(T))) both on the binding (DeltaE) and relative (DeltaDeltaE) energies for a large number of systems including four water dimer stationary points and 57 other clusters up to undecamers, (H2O)11.	Water	222-227	tryptase pseudogene 1	Homo sapiens	86-89
18967721-5	1999	A sequential extraction of a water sample with n-hexane and ethyl acetate is used to separate NS and other interferents as well as dichloromethane and chloroform for the separation of PEG into LC- and SC-fractions.	Water	29-34	progestagen associated endometrial protein	Homo sapiens	184-187
10742477-2	2000	This thirst for water is so pervasive that many wetlands considered to be hemispheric reserves for waterbirds have been heavily affected; for example, the California and Nevada wetlands in North America, the Macquarie Marshes in Australia, and the Aral Sea in central Asia.	Water	16-21	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	253-256
26574355-2	2015	We evaluated the importance and reliability of small basis set CCSD(T) corrections to MP2 (delta(MP2)(CCSD(T))) both on the binding (DeltaE) and relative (DeltaDeltaE) energies for a large number of systems including four water dimer stationary points and 57 other clusters up to undecamers, (H2O)11.	Water	293-296	tryptase pseudogene 1	Homo sapiens	86-89
25854248-2	2015	The fluid is modeled using an effective pair potential derived from the ST4 atomistic model for water.	Water	96-101	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	72-75
10792624-1	2000	BACKGROUND: Enhanced expression of the kidney-specific sodium transporter, rBSC1, in the thick ascending limb of Henle (TAL) and of the renal water channel, aquaporin-2 (AQP2), in collecting duct has been identified in rats with congestive heart failure (CHF) as a cause for enhanced sodium and water retention in this condition.	Water	295-300	aquaporin 2	Rattus norvegicus	157-168
10502361-1	1999	This report describes an investigation aimed at preparation of radioiodinated cyanocobalamin (CN-Cbl) monomers and dimers with improved water solubility and decreased nonspecific binding.	Water	136-141	Cbl proto-oncogene	Homo sapiens	97-100
25836281-7	2015	Additionally, there are hydrogen-bonding interactions involving the solvent water molecules and the arsonate and amine groups of the Hapa(-) ligands, and weak pi-pi stacking interactions within the [Ag(Hapa)(PPh3)]n layer.	Water	76-81	protein phosphatase 4 catalytic subunit	Homo sapiens	208-212
10438630-4	1999	FKBP12, with 107 residues, is the largest protein to date which folds with simple two-state kinetics in water (kF=4 s(-1)at 25 degrees C).	Water	104-109	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	0-6
10875682-11	2000	The more water-soluble GE, o-CGE and HDDGE, were good substrates for GST whereas the more lipophilic GE, YX4000 and C12GE, were poor substrates for GST.	Water	9-14	glutathione S-transferase kappa 1	Homo sapiens	69-72
10766803-2	2000	Binding of aquo-, cyano-, or azidocobalamin (Cbl.OH(2), Cbl.CN, and Cbl.N(3), respectively) to the recombinant human transcobalamin (TC) and haptocorrin from human plasma was investigated via stopped-flow spectroscopy.	Water	49-54	Cbl proto-oncogene	Homo sapiens	45-48
10446804-8	1999	We then transplanted the C6 clone into the striatum of nude mice and regulated CD24 expression via tetracycline in the drinking water (1 mg/ml).	Water	128-133	CD24a antigen	Mus musculus	79-83
25341403-9	2015	However, recognition of diclofenac by CYP105D7 was completely different from that of rabbit CYP2C5, which binds one diclofenac molecule with a cluster of water molecules.	Water	154-159	cytochrome P450 2C5	Oryctolagus cuniculus	92-98
10476074-10	1999	It is postulated that an important function of AtSUC1 is the cell-specific modulation of water potentials.	Water	89-94	sucrose-proton symporter 1	Arabidopsis thaliana	47-53
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	23-28	Cbl proto-oncogene	Homo sapiens	19-22
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	23-28	Cbl proto-oncogene	Homo sapiens	111-114
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	23-28	Cbl proto-oncogene	Homo sapiens	111-114
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	115-120	Cbl proto-oncogene	Homo sapiens	19-22
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	115-120	Cbl proto-oncogene	Homo sapiens	111-114
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	115-120	Cbl proto-oncogene	Homo sapiens	111-114
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	173-178	Cbl proto-oncogene	Homo sapiens	19-22
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	173-178	Cbl proto-oncogene	Homo sapiens	111-114
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	173-178	Cbl proto-oncogene	Homo sapiens	111-114
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	141-146	Cbl proto-oncogene	Homo sapiens	153-156
10407079-10	1999	Exposing cells to 10 microM Hg or 140 nM insulin both increased cellular water content by 18% and increased hexose transport 2-4-fold.	Water	73-78	insulin S homeolog	Xenopus laevis	41-48
10435672-2	1999	With the identification of the two genes involved in NDI, namely the vasopressin type-2 receptor (V2R) and the aquaporin-2 water channel (AQP2) genes, the identification of a large number of different mutations in these genes, and the subsequent functional characterization of mutant V2Rs and AQP2s, our insight into the renal cellular mechanisms involved in diuresis and antidiuresis has increased considerably.	Water	123-128	aquaporin 2	Homo sapiens	138-142
24474672-4	2015	The fluorescence intensity of water extracts of Caulis Spatholobi, Flos Carthami and Rhizoma Curcumae on the expression of P-selectin in human platelets of healthy persons was measured with flow cytometry.	Water	30-35	selectin P	Homo sapiens	123-133
10366731-1	1999	The surface tension behaviour of oxidised cytochrome c (cyt c) solution was characterised at various pH and ionic strength at the air/water interface.	Water	134-139	cytochrome c, somatic	Equus caballus	42-54
10366731-1	1999	The surface tension behaviour of oxidised cytochrome c (cyt c) solution was characterised at various pH and ionic strength at the air/water interface.	Water	134-139	cytochrome c, somatic	Equus caballus	56-61
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	141-146	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	141-146	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	157-162	Cbl proto-oncogene	Homo sapiens	153-156
24893788-3	2015	Ca(2+) uptake and the expression of gcm2 messenger RNA (mRNA) were significantly elevated in larvae acclimated to low Ca(2+) water (25 muM); the stimulation of Ca(2+) uptake was not observed in fish experiencing gcm2 knockdown.	Water	125-130	glial cells missing transcription factor 2	Danio rerio	36-40
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	157-162	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	157-162	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	232-237	Cbl proto-oncogene	Homo sapiens	153-156
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	232-237	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	232-237	Cbl proto-oncogene	Homo sapiens	213-216
10933044-3	1999	Recent studies suggest that the apparent diffusion coefficient of water (ADCw), measured noninvasively with magnetic resonance imaging, is sensitively and reliably increased in response to successful CTx.	Water	66-71	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	200-203
10370092-7	1999	The finding of AQP3 in the intestinal epithelia strongly suggests that this protein functions as a pathway for water transport in this epithelium.	Water	111-116	aquaporin 3 (Gill blood group)	Rattus norvegicus	15-19
24893788-6	2015	Acclimation of larvae to acidic water significantly increased gcm2 mRNA expression, and in gcm2 morphants, no such stimulation in Ca(2+) uptake was observed after their return to control water.	Water	32-37	glial cells missing transcription factor 2	Danio rerio	62-66
25207794-1	2015	Frozen core MP2 and DFT computations were carried out on possible configurations of 1:1 H2SO4 CH3OH and 1:1:1 H2SO4 CH3OH H2O complexes.	Water	122-125	tryptase pseudogene 1	Homo sapiens	12-15
10386909-2	1999	injection of corticotrophin releasing factor (CRF) on food and water intake and on body temperature in chickens was determined.	Water	63-68	corticotropin releasing hormone	Gallus gallus	13-44
10804541-0	2000	Synthesis and characterization of water-soluble amino fullerene derivatives [formula: see text] A series of amino-substituted methanofullerene derivatives were prepared by mono-, tris-, and hexa-Bingel-Hirsch reactions using an N-protected malonate derivative.	Water	34-39	hexosaminidase subunit alpha	Homo sapiens	190-194
10804541-1	2000	Upon scission of the protecting groups, the e,e,e-tris- and octahedral Th hexa-methano amino fullerenes were found to be among the most water-soluble fullerene derivatives yet prepared.	Water	136-141	hexosaminidase subunit alpha	Homo sapiens	74-78
25424198-1	2015	The complexes of acetic acid (AcOH) with water have been studied using FTIR matrix isolation spectroscopy and DFT/B3LYP, DFT/B3LYP-D, and MP2 calculations with the aug-cc-pVTZ basis set.	Water	41-46	tryptase pseudogene 1	Homo sapiens	138-141
10753653-1	2000	The present study was undertaken to assess whether the protein and mRNA expression levels of the glial water channel aquaporin-4 (AQP4) undergo downregulation and whether there is a subcellular redistribution of AQP4 protein in rat brain in response to systemic hyponatremia and brain edema.	Water	103-108	aquaporin 4	Rattus norvegicus	117-128
10753653-1	2000	The present study was undertaken to assess whether the protein and mRNA expression levels of the glial water channel aquaporin-4 (AQP4) undergo downregulation and whether there is a subcellular redistribution of AQP4 protein in rat brain in response to systemic hyponatremia and brain edema.	Water	103-108	aquaporin 4	Rattus norvegicus	130-134
10232700-1	1999	Several aquaporin-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the collecting duct; AQP6 in the papilla; and AQP7 in the proximal tubule.	Water	23-28	aquaporin 2	Mus musculus	139-143
10232700-1	1999	Several aquaporin-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the collecting duct; AQP6 in the papilla; and AQP7 in the proximal tubule.	Water	23-28	aquaporin 7	Mus musculus	209-213
26029382-0	2015	Crystal structures of the water and acetone monosolvates of bis-[4"-(pyridin-4-yl)-2,2":6",2""-terpyridine]-manganese(II) bis-(hexa-fluorido-phosphate).	Water	26-31	hexosaminidase subunit alpha	Homo sapiens	127-131
11670948-6	1999	The packing motif of CF(2)Cbl is very similar to that described for wet vitamin B(12), a distorted hexagonal close packing of the cobalamin, with channels of water running parallel to the crystallographic c axis through the crystal at x = (1)/(4), y = 0, and x = (3)/(4), y = (1)/(2), respectively.	Water	158-163	Cbl proto-oncogene	Homo sapiens	26-29
25798240-2	2015	ANP may participate in the regulation of the water-electrolyte balance.	Water	45-50	natriuretic peptide type A	Mus musculus	0-3
10198347-4	1999	Chronic stress (3 h/day, water avoidance or wrap restraint on alternate days for 6 days) aggravated colitis more in Lewis than Fischer rats (71 and 22% further increase in MPO activity, respectively).	Water	25-30	myeloperoxidase	Rattus norvegicus	172-175
10731509-9	2000	There was a significant (P = 0.01) progressive decrease in urinary CTx after ingestion of the high-calcium water, whereas after ingestion of low-calcium water the changes were modest and not significant.	Water	107-112	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	67-70
10731509-10	2000	The fall in serum CTx concentrations was 34.7% 3 h after ingestion of high-calcium water, compared with 17.6% with the control.	Water	83-88	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	18-21
10731509-11	2000	The decreases in serum CTx concentrations were significantly (P &lt; 0.05) lower 1, 2, 3, and 4 h after ingestion of high-calcium water than after ingestion of the control.	Water	130-135	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	23-26
10751327-1	2000	Aquaporin 2 (AQP2), the vasopressin-regulated water channel, was originally identified in renal collecting duct principal cells.	Water	46-51	aquaporin 2	Rattus norvegicus	0-11
10751327-1	2000	Aquaporin 2 (AQP2), the vasopressin-regulated water channel, was originally identified in renal collecting duct principal cells.	Water	46-51	aquaporin 2	Rattus norvegicus	13-17
10049540-3	1999	The introduction of Cd2+ ions in subphase had a marked effect on the process of the organization of the amphiphilic polymer at the air/water interface due to the association of Cd2+ ions with the hydrophilic network, which could be indicated by the pressure-area isotherms and Brewster Angle Microscopy.	Water	135-140	CD2 molecule	Homo sapiens	20-23
26045822-1	2015	Aquaporin-4 (AQP4) is the most popular water channel protein expressed in brain tissue and plays a very important role in regulating the water balance in and outside of brain parenchyma.	Water	39-44	aquaporin 4	Rattus norvegicus	0-11
10751327-2	2000	However, our recent description of AQP2 in the vas deferens indicated that this water channel may have extra-renal functions, possibly related to sperm concentration in the male reproductive tract.	Water	80-85	aquaporin 2	Rattus norvegicus	35-39
26045822-1	2015	Aquaporin-4 (AQP4) is the most popular water channel protein expressed in brain tissue and plays a very important role in regulating the water balance in and outside of brain parenchyma.	Water	39-44	aquaporin 4	Rattus norvegicus	13-17
10103087-11	1999	The time course and pattern of AQP4 expression suggests that this aquaporin plays an important role in brain water and K+ homeostasis from the second week of development.	Water	109-114	aquaporin 4	Rattus norvegicus	31-35
25476521-2	2015	However, plastic substrates such as PEN and PET are permeable to water, oxygen and volatile electrolyte solvents, which is detrimental to the cell stability.	Water	65-70	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	36-39
10073616-4	1999	AQP2 is abundant in the collecting duct principal cells and is the chief target for vasopressin to regulate collecting duct water reabsorption.	Water	124-129	aquaporin 2	Homo sapiens	0-4
10073616-9	1999	Conversely, AQP2 expression and targeting appear to be increased in some conditions with water retention such as pregnancy and congestive heart failure.	Water	89-94	aquaporin 2	Homo sapiens	12-16
10073616-10	1999	AQP3 and AQP4 are basolateral water channels located in the kidney collecting duct, and AQP6 and AQP7 appear to be expressed at lower abundance at several sites including the proximal tubule.	Water	30-35	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
11709841-3	2000	The amount of protein adsorption was inversely correlated with the degree of water structuring around the PEG molecules, which facilitates the formation of a strongly bound water film to increase the surface hydration.	Water	77-82	progestagen associated endometrial protein	Homo sapiens	106-109
11709841-3	2000	The amount of protein adsorption was inversely correlated with the degree of water structuring around the PEG molecules, which facilitates the formation of a strongly bound water film to increase the surface hydration.	Water	173-178	progestagen associated endometrial protein	Homo sapiens	106-109
10766399-0	2000	Urinary excretion of aquaporin-2 in pathological states of water metabolism.	Water	59-64	aquaporin 2	Homo sapiens	21-32
10766399-1	2000	Aquaporin-2 (AQP-2) is an arginine vasopressin (AVP)-regulated water channel in renal collecting duct cells.	Water	63-68	aquaporin 2	Homo sapiens	0-11
10766399-1	2000	Aquaporin-2 (AQP-2) is an arginine vasopressin (AVP)-regulated water channel in renal collecting duct cells.	Water	63-68	aquaporin 2	Homo sapiens	13-18
25503851-0	2015	Methane-rich water induces cucumber adventitious rooting through heme oxygenase1/carbon monoxide and Ca(2+) pathways.	Water	13-18	heme oxygenase 1, chloroplastic	Cucumis sativus	65-80
10759215-4	2000	Restraint and water immersion stress rapidly activated heat shock factor 1 (HSF1) in rat gastric mucosa within 15 min and induced HSP70 mRNA expression and its protein accumulation.	Water	14-19	heat shock transcription factor 1	Rattus norvegicus	55-74
10759215-4	2000	Restraint and water immersion stress rapidly activated heat shock factor 1 (HSF1) in rat gastric mucosa within 15 min and induced HSP70 mRNA expression and its protein accumulation.	Water	14-19	heat shock transcription factor 1	Rattus norvegicus	76-80
9989943-7	1999	In the case of water, nuclear Phi values approached those of the extracellular space while mitochondrial Phi values were significantly higher than those of the cytoplasm.	Water	15-20	glucose-6-phosphate isomerase	Rattus norvegicus	30-33
25503851-1	2015	KEY MESSAGE: Methane-rich water triggered adventitious rooting by regulating heme oxygenase1/carbon monoxide and calcium pathways in cucumber explants.	Water	26-31	heme oxygenase 1, chloroplastic	Cucumis sativus	77-92
10759215-4	2000	Restraint and water immersion stress rapidly activated heat shock factor 1 (HSF1) in rat gastric mucosa within 15 min and induced HSP70 mRNA expression and its protein accumulation.	Water	14-19	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	130-135
25203215-0	2015	A TDDFT/EFP1 study on hydrogen bonding dynamics of coumarin 151 in water.	Water	67-72	thioredoxin domain containing 11	Homo sapiens	8-12
10829724-1	2000	The purpose of this study is to examine the possibility of the NDE of concrete from a knowledge of the relationship between water content and ultrasonic propagation in concrete.	Water	124-129	nudE neurodevelopment protein 1	Homo sapiens	63-66
10099706-0	1999	Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.	Water	35-40	aquaporin 2	Homo sapiens	69-79
10099706-1	1999	Vasopressin or AVP regulates water reabsorption by the kidney inner medullary collecting duct (IMCD) through the insertion and removal of aquaporin (AQP) 2 water channels into the IMCD apical membrane.	Water	29-34	aquaporin 2	Homo sapiens	149-155
10099706-1	1999	Vasopressin or AVP regulates water reabsorption by the kidney inner medullary collecting duct (IMCD) through the insertion and removal of aquaporin (AQP) 2 water channels into the IMCD apical membrane.	Water	156-161	aquaporin 2	Homo sapiens	149-155
25311520-1	2015	The interaction of Cd(II) with the non-steroidal anti-inflammatory drug diclofenac sodium (Dic) leads to the formation of the complex [Cd2(L)41.5(MeOH)2(H2O)]n(L = Dic), 1, which has been isolated and structurally characterized by X-ray crystallography.	Water	153-156	CD2 molecule	Homo sapiens	135-138
10449905-0	1999	Cloning, structural organization and chromosomal localization of the mouse aquaporin-8 water channel gene (Aqp8).	Water	87-92	aquaporin 8	Mus musculus	75-86
10449905-0	1999	Cloning, structural organization and chromosomal localization of the mouse aquaporin-8 water channel gene (Aqp8).	Water	87-92	aquaporin 8	Mus musculus	107-111
10669780-7	2000	Since relatively few beta-galactosidase conjugated antibodies are commercially available, we describe an efficient method to couple beta-galactosidase to antibodies using a novel water soluble heterobifunctional crosslinker, sulfosuccinimidyl 4-[N-maleimidomethyl]-cyclohexane-1-carboxylate (sulfo-SMCC).	Water	179-184	galactosidase, beta 1	Mus musculus	21-39
10669780-7	2000	Since relatively few beta-galactosidase conjugated antibodies are commercially available, we describe an efficient method to couple beta-galactosidase to antibodies using a novel water soluble heterobifunctional crosslinker, sulfosuccinimidyl 4-[N-maleimidomethyl]-cyclohexane-1-carboxylate (sulfo-SMCC).	Water	179-184	galactosidase, beta 1	Mus musculus	132-150
25311520-1	2015	The interaction of Cd(II) with the non-steroidal anti-inflammatory drug diclofenac sodium (Dic) leads to the formation of the complex [Cd2(L)41.5(MeOH)2(H2O)]n(L = Dic), 1, which has been isolated and structurally characterized by X-ray crystallography.	Water	153-156	dynein axonemal intermediate chain 1	Homo sapiens	164-171
9843709-11	1998	The mercury derivative p-chloromercuriphenylsulfonic acid (PCMBS), which inhibits the H2O movement through AQP1, also blocks the AQP1-dependent increase in CO2 permeability.	Water	86-89	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	107-111
25391898-6	2015	ENaC activity was elevated in mice that consumed 3% NaCl solution compared with mice that consumed a diet enriched in Na(+) with ad libitum tap water; the latter diet does not cause hypernatremia.	Water	144-149	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	0-4
9843010-8	1998	The ratio of low echogenic pixel number to total pixel number (LEP/TP), which correlates with dermal water, was measured before and after 5 days of applied compression in two treatment courses where classes of compression were switched randomly.	Water	101-106	leptin	Homo sapiens	63-66
10642039-5	2000	We found that CA1 seizures significantly disrupted water maze performance during both acquisition and retention, and the effects were similar when either non-convulsive or fully generalized convulsive seizures were evoked.	Water	51-56	carbonic anhydrase 1	Rattus norvegicus	14-17
25391898-11	2015	These results demonstrate that stimulation of ENaC by AVP plays a critical role in water homeostasis by facilitating urinary concentration, which can compensate for hypernatremia or exacerbate hyponatremia.	Water	83-88	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	46-50
9848772-3	1998	Dysregulation of aquaporin-2 (AQP2), the predominant vasopressin-regulated water channel, is known to be associated with a range of congenital and acquired water balance disorders including nephrogenic diabetes insipidus and states of water retention.	Water	75-80	aquaporin 2	Rattus norvegicus	17-28
9848772-3	1998	Dysregulation of aquaporin-2 (AQP2), the predominant vasopressin-regulated water channel, is known to be associated with a range of congenital and acquired water balance disorders including nephrogenic diabetes insipidus and states of water retention.	Water	75-80	aquaporin 2	Rattus norvegicus	30-34
10968208-9	2000	The water permeability in MDCK cells transfected with aquaporin 2 was an order of magnitude higher than in the intact MDCK cell line.	Water	4-9	aquaporin 2	Canis lupus familiaris	54-65
25391898-12	2015	The present findings are consistent with ENaC in addition to serving as a final effector of the renin-angiotensin-aldosterone system and blood pressure homeostasis, also playing a key role in water homeostasis by regulating urine concentration and dilution of plasma.	Water	192-197	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	41-45
25594563-3	2015	AQP2 is localized mainly in the kidney and plays a critical role in determining cellular water content.	Water	89-94	aquaporin 2	Homo sapiens	0-4
11051036-5	2000	The intradialytic decrease in plasma water beta2-microglobulin concentrations was 73% (vs 53% in HD) followed by a post-dialytic rebound of 85% (vs 42% in HD).	Water	37-42	beta-2-microglobulin	Homo sapiens	43-62
11051036-9	2000	HF makes it possible to obtain constantly lower plasma water beta2-microglobulin concentrations whose long-term clinical relevance has to be verified.	Water	55-60	beta-2-microglobulin	Homo sapiens	61-80
10052620-8	1998	Positive NOESY cross-peaks were measured between the water protons and the H2 protons of A15, A16 and A17 reflecting the occurrence of hydration water molecules with residence times longer than 500 picoseconds along the minor groove of the TTT/AAA segment.	Water	53-58	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	94-97
10052620-8	1998	Positive NOESY cross-peaks were measured between the water protons and the H2 protons of A15, A16 and A17 reflecting the occurrence of hydration water molecules with residence times longer than 500 picoseconds along the minor groove of the TTT/AAA segment.	Water	53-58	immunoglobulin kappa variable 2-30	Homo sapiens	102-105
10052620-8	1998	Positive NOESY cross-peaks were measured between the water protons and the H2 protons of A15, A16 and A17 reflecting the occurrence of hydration water molecules with residence times longer than 500 picoseconds along the minor groove of the TTT/AAA segment.	Water	145-150	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	94-97
10052620-8	1998	Positive NOESY cross-peaks were measured between the water protons and the H2 protons of A15, A16 and A17 reflecting the occurrence of hydration water molecules with residence times longer than 500 picoseconds along the minor groove of the TTT/AAA segment.	Water	145-150	immunoglobulin kappa variable 2-30	Homo sapiens	102-105
10052620-11	1998	In contrast, the widening of the minor groove at the A11:T14 base-pair ending the TTTA/TAAA segment, likely associated to a high negative propeller twist value at this base-pair, prevents the binding of a water molecule with long residence time to A11 but not to A15 of the preceding T10:A15 base-pair.	Water	205-210	DXS435E	Homo sapiens	53-56
10052620-11	1998	In contrast, the widening of the minor groove at the A11:T14 base-pair ending the TTTA/TAAA segment, likely associated to a high negative propeller twist value at this base-pair, prevents the binding of a water molecule with long residence time to A11 but not to A15 of the preceding T10:A15 base-pair.	Water	205-210	DXS435E	Homo sapiens	248-251
10052620-12	1998	Thus, in our non-palindromic oligonucleotide the water molecules bind differently to A11 and A15 although both adenines are part of a TpA step.	Water	49-54	DXS435E	Homo sapiens	85-88
10855836-2	1999	In this trial the effects of an angiotensin-converting enzyme (ACE) inhibitor were quantified in sheep on restricted water intake.	Water	117-122	angiotensin-converting enzyme	Ovis aries	63-66
9849941-9	1998	We have examined the electrostatic, hydrophobic, and water accessible surfaces of ALBP in the apo form and of holo forms with a variety of bound ligands.	Water	53-58	fatty acid binding protein 4	Homo sapiens	82-86
25594563-5	2015	By up-regulating the expression levels of AQP2, statins increase water reabsorption by the kidney, thus opening up a new avenue in treating patients with nephrogenic diabetes insipidus (NDI), a hereditary disease that yet lacks high-powered and limited side effects therapy.	Water	65-70	aquaporin 2	Homo sapiens	42-46
25529759-3	2015	RBS is also a reversible sensor, and it can be made into test paper to detect Pd(2+) in pure water.	Water	93-98	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	0-3
9851705-7	1998	In trifluoroethanol/water mixtures, NAC and NAC-(19-35)-peptide adopted alpha-helical structure but NAC-(1-18)-peptide did not.	Water	20-25	synuclein alpha	Homo sapiens	36-39
25544560-4	2015	Mutations in the gene encoding the glycogen phosphatase laforin result in hyperphosphorylated glycogen that forms water-insoluble inclusions called Lafora bodies (LBs).	Water	114-119	EPM2A glucan phosphatase, laforin	Homo sapiens	56-63
9851705-7	1998	In trifluoroethanol/water mixtures, NAC and NAC-(19-35)-peptide adopted alpha-helical structure but NAC-(1-18)-peptide did not.	Water	20-25	synuclein alpha	Homo sapiens	44-47
9851705-7	1998	In trifluoroethanol/water mixtures, NAC and NAC-(19-35)-peptide adopted alpha-helical structure but NAC-(1-18)-peptide did not.	Water	20-25	synuclein alpha	Homo sapiens	44-47
10556122-5	1999	Mean (+/- SD) twitch Pdi (TwPdi) fell significantly (p &lt; 0.01) at 20 min after the control and hypercapnic MVV; (30.4 [7.8] to 27.0 [8.1] cm H(2)O control and 30.3 [4.1] to 27.3 [5.0] cm H(2)O CO(2)) and remained significantly (p &lt; 0.01) below baseline.	Water	144-149	peptidyl arginine deiminase 1	Homo sapiens	21-24
9851705-8	1998	NAC-(1-18)-peptide and NAC formed beta-sheet in acetonitrile/water mixtures more readily than did NAC-(19-35)-peptide.	Water	61-66	synuclein alpha	Homo sapiens	0-3
25379648-9	2015	In reduced NQO2, DMAT occupies a more peripheral region and hydrogen and halogen bonds with the enzyme are mediated through three water molecules.	Water	130-135	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	11-15
9851705-8	1998	NAC-(1-18)-peptide and NAC formed beta-sheet in acetonitrile/water mixtures more readily than did NAC-(19-35)-peptide.	Water	61-66	synuclein alpha	Homo sapiens	23-26
9851705-8	1998	NAC-(1-18)-peptide and NAC formed beta-sheet in acetonitrile/water mixtures more readily than did NAC-(19-35)-peptide.	Water	61-66	synuclein alpha	Homo sapiens	23-26
10542049-6	1999	The urea-induced unfolding profiles of PEBP show a midpoint of the two-state unfolding transition at 4.8 M denaturant, and the stability of PEBP is 4.5 kcal.mol-1 at 25 degrees C. Moreover, the surface active properties indicate that PEBP is essentially a hydrophilic protein which progressively unfolds at the air/water interface over the course of time.	Water	315-320	phosphatidylethanolamine binding protein 1	Bos taurus	39-43
25408475-1	2015	The peptide GSFSIQYTYHV derived from human semenogelin I forms a transparent hydrogel through spontaneous self-assembly in water at neutral pH.	Water	123-128	semenogelin 1	Homo sapiens	43-56
10542049-6	1999	The urea-induced unfolding profiles of PEBP show a midpoint of the two-state unfolding transition at 4.8 M denaturant, and the stability of PEBP is 4.5 kcal.mol-1 at 25 degrees C. Moreover, the surface active properties indicate that PEBP is essentially a hydrophilic protein which progressively unfolds at the air/water interface over the course of time.	Water	315-320	phosphatidylethanolamine binding protein 1	Bos taurus	140-144
10542049-6	1999	The urea-induced unfolding profiles of PEBP show a midpoint of the two-state unfolding transition at 4.8 M denaturant, and the stability of PEBP is 4.5 kcal.mol-1 at 25 degrees C. Moreover, the surface active properties indicate that PEBP is essentially a hydrophilic protein which progressively unfolds at the air/water interface over the course of time.	Water	315-320	phosphatidylethanolamine binding protein 1	Bos taurus	140-144
9822112-4	1998	Nephrogenic diabetes insipidus is characterized by the inability of the kidney to concentrate urine in response to vasopressin; the vasopressin type-2 receptor and the AQP2 water channel have both been shown to be involved in this disease.	Water	173-178	aquaporin 2	Homo sapiens	168-172
9822112-5	1998	This article focuses on mutations in the vasopressin V2 receptor and aquaporin-2 water channel identified in nephrogenic diabetes insipidus patients, and on the effects of these mutations on the transport and function of these proteins upon expression in cell systems.	Water	81-86	aquaporin 2	Homo sapiens	69-80
9822113-1	1998	Several aquaporin-type water channels are expressed in mammalian kidney and lung: AQP1 in lung microvessels and kidney proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 in apical membrane of collecting duct epithelium; AQP3 and AQP4 in basolateral membranes of airway and collecting duct epithelium; and AQP5 in alveolar epithelium.	Water	23-28	aquaporin 2	Homo sapiens	183-187
9822113-1	1998	Several aquaporin-type water channels are expressed in mammalian kidney and lung: AQP1 in lung microvessels and kidney proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 in apical membrane of collecting duct epithelium; AQP3 and AQP4 in basolateral membranes of airway and collecting duct epithelium; and AQP5 in alveolar epithelium.	Water	23-28	aquaporin 3 (Gill blood group)	Homo sapiens	238-242
25403323-0	2015	W246(6.48) opens a gate for a continuous intrinsic water pathway during activation of the adenosine A2A receptor.	Water	51-56	adenosine A2a receptor	Homo sapiens	90-112
9822113-1	1998	Several aquaporin-type water channels are expressed in mammalian kidney and lung: AQP1 in lung microvessels and kidney proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 in apical membrane of collecting duct epithelium; AQP3 and AQP4 in basolateral membranes of airway and collecting duct epithelium; and AQP5 in alveolar epithelium.	Water	23-28	aquaporin 5	Homo sapiens	323-327
9831428-4	1998	In &lt;10% of the families studied, congenital NDI has an autosomal recessive inheritance and mutations of the aquaporin-2 gene (AQP2), ie, the vasopressin-sensitive water channel, have been identified.	Water	166-171	aquaporin 2	Homo sapiens	111-122
10621939-2	1999	Exposure of rats to restraint and water-immersion stress rapidly and transiently activated heart shock factor 1 (HSF1) and caused rapid HSP70 mRNA expression and HSP70 accumulation in gastric mucosa.	Water	34-39	heat shock transcription factor 1	Rattus norvegicus	91-111
10621939-2	1999	Exposure of rats to restraint and water-immersion stress rapidly and transiently activated heart shock factor 1 (HSF1) and caused rapid HSP70 mRNA expression and HSP70 accumulation in gastric mucosa.	Water	34-39	heat shock transcription factor 1	Rattus norvegicus	113-117
10621939-2	1999	Exposure of rats to restraint and water-immersion stress rapidly and transiently activated heart shock factor 1 (HSF1) and caused rapid HSP70 mRNA expression and HSP70 accumulation in gastric mucosa.	Water	34-39	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	136-141
10621939-2	1999	Exposure of rats to restraint and water-immersion stress rapidly and transiently activated heart shock factor 1 (HSF1) and caused rapid HSP70 mRNA expression and HSP70 accumulation in gastric mucosa.	Water	34-39	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	162-167
9831428-4	1998	In &lt;10% of the families studied, congenital NDI has an autosomal recessive inheritance and mutations of the aquaporin-2 gene (AQP2), ie, the vasopressin-sensitive water channel, have been identified.	Water	166-171	aquaporin 2	Homo sapiens	129-133
10029181-8	1998	The ECM often contains aggrecan which allows the tendon to imbibe water and withstand compression.	Water	66-71	multimerin 1	Homo sapiens	4-7
25382142-3	2015	MLC1 is involved in ion-water homeostasis, but its exact role is unknown.	Water	24-29	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	0-4
10510301-0	1999	Hydration change during the aging of phosphorylated human butyrylcholinesterase: importance of residues aspartate-70 and glutamate-197 in the water network as probed by hydrostatic and osmotic pressures.	Water	142-147	butyrylcholinesterase	Homo sapiens	58-79
25382142-9	2015	Mlc1-null mice had early onset megalencephaly and increased brain water content.	Water	66-71	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	0-4
9774416-5	1998	This alteration was predicted to promote hydrophobic interactions at the MHC I heavy chain/beta2m interface and displace an ordered water molecule.	Water	132-137	beta-2-microglobulin	Homo sapiens	91-97
25658222-9	2015	Precision of the spectrometer, determined using Allan variance analysis, is 3.3 nmol/mol for CO2 and 21 nmol/mol for H2O.	Water	117-120	complement C2	Homo sapiens	93-103
9756653-4	1998	beta-casein was used to generate a standard curve for relating interfacial radioactivity (microCi/m2) to cpm at the oil-water interface.	Water	120-125	casein beta	Homo sapiens	0-11
9756653-9	1998	The most significant difference between the adsorption of beta-casein at the oil-water and air-water interfaces was the lack of an induction period for the development of interfacial pressure in the former.	Water	81-86	casein beta	Homo sapiens	58-69
9756653-9	1998	The most significant difference between the adsorption of beta-casein at the oil-water and air-water interfaces was the lack of an induction period for the development of interfacial pressure in the former.	Water	95-100	casein beta	Homo sapiens	58-69
10510365-4	1999	The resulting data showed a correlation between the incidence of S-Ag chimerism and the loss of susceptibility to EAU.	Water	114-117	S-antigen visual arrestin	Rattus norvegicus	65-69
10516647-4	1999	Metabolic poisoning of Xenopus laevis oocytes with sodium azide and application of the K+ channel opener drug diazoxide induced K+ channel currents in oocytes co-injected with cRNA for hKir6.1 and hamster sulphonylurea receptor (SUR1), but not in oocytes injected with water or cRNA for hKir6.1 or SUR1 alone.	Water	269-274	potassium inwardly rectifying channel subfamily J member 8	Homo sapiens	185-227
10516647-4	1999	Metabolic poisoning of Xenopus laevis oocytes with sodium azide and application of the K+ channel opener drug diazoxide induced K+ channel currents in oocytes co-injected with cRNA for hKir6.1 and hamster sulphonylurea receptor (SUR1), but not in oocytes injected with water or cRNA for hKir6.1 or SUR1 alone.	Water	269-274	potassium inwardly rectifying channel subfamily J member 8	Homo sapiens	185-192
25654092-3	2015	Conjugated polymer based water-dispersible nanoparticles (CPN) represent a new class of probes because they offer high brightness, improved photostability, high fluorescent quantum yield, and noncytotoxicity comparing to conventional dyes and quantum dots.	Water	25-30	carboxypeptidase N subunit 1	Rattus norvegicus	58-61
10510269-8	1999	The presence of AQP3 in villus epithelial cells suggests that AQP3 is implicated in water absorption across human colonic surface cells.	Water	84-89	aquaporin 3 (Gill blood group)	Homo sapiens	16-20
10510269-8	1999	The presence of AQP3 in villus epithelial cells suggests that AQP3 is implicated in water absorption across human colonic surface cells.	Water	84-89	aquaporin 3 (Gill blood group)	Homo sapiens	62-66
9774713-1	1998	The structure of a synthesized peptide with the sequence GVVDLNWAAEVLKVQKRRIYDITNVLEGIQ which corresponds to residues 149-178 of transcription factor E2F-1 was determined by 1H nuclear magnetic resonance in 40% d3-TFE/water.	Water	218-223	E2F transcription factor 1	Homo sapiens	150-155
21644714-3	1998	Hydrolysis of the substrate, mediated by phospholipase A(2), leads to the formation of water-soluble products from the insoluble substrate.	Water	87-92	phospholipase A and acyltransferase 1	Homo sapiens	41-56
25897893-4	2015	To overcome the known human toxicities associated with these compounds, a water-soluble small molecule inhibitor, LB100, was recently developed to competitively inhibit the PP2A protein.	Water	74-79	protein phosphatase 2 phosphatase activator	Homo sapiens	173-177
9753281-7	1998	Expression of HSP60 was significantly increased by water-immersion stress or TRH administration in the small intestinal mucosa, whereas HSP72 and HSP90 did not increase.	Water	51-56	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	14-19
10534423-13	1999	Increased expression of NHE-3 secondary to SBR and/or EGF treatment with loss of this increase following salivarectomy implies a common mechanism to enhance enterocyte proliferation and luminal absorption of NaCl and water.	Water	217-222	epidermal growth factor	Mus musculus	54-57
10477136-1	1999	Four prostaglandin E2 receptor subtypes designated EP1, EP2, EP3, and EP4 have been shown to mediate a variety of effects of prostaglandin E2 (PGE2) on glomerular hemodynamics, tubular salt and water reabsorption, and on blood vessels in the human kidney.	Water	194-199	prostaglandin E receptor 1	Homo sapiens	51-54
10477136-1	1999	Four prostaglandin E2 receptor subtypes designated EP1, EP2, EP3, and EP4 have been shown to mediate a variety of effects of prostaglandin E2 (PGE2) on glomerular hemodynamics, tubular salt and water reabsorption, and on blood vessels in the human kidney.	Water	194-199	prostaglandin E receptor 4	Homo sapiens	70-73
9753281-13	1998	We demonstrated that water-immersion stress or TRH administration specifically induced HSP60, although preinduction of this protein did not show a cytoprotective function in the small intestinal mucosa.	Water	21-26	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	87-92
25662477-11	2015	CONCLUSIONS: Taken together these results provide a possible molecular mechanism explaining the increased AQP2 membrane expression under RGZ treatment: in renal cells RGZ elicits Ca(2+) transients facilitating AQP2 exposure at the apical plasma membrane, thus increasing collecting duct water permeability.	Water	287-292	aquaporin 2	Homo sapiens	106-110
9756088-2	1998	This is a rare, but now well described entity secondary to either mutations in the AVPR2 gene that codes for the vasopressin antidiuretic (V2) receptor or to mutations in the AQP2 gene that codes for the vasopressin-dependent water channel.	Water	226-231	aquaporin 2	Homo sapiens	175-179
9756089-0	1998	Aquaporin-2 water channel mutations causing nephrogenic diabetes insipidus.	Water	12-17	aquaporin 2	Homo sapiens	0-11
9756089-2	1998	Aquaporin-2 is the vasopressin-responsive water channel in the collecting duct, and vasopressin control of water permeability in the collecting duct occurs in two ways: a short-term regulation and a long-term adaptation.	Water	42-47	aquaporin 2	Homo sapiens	0-11
10495124-5	1999	On the central axis the stopping-power ratio variations for narrow beams compared with normally incident broad beams were 0.1% or less for water-to-LiF-100, graphite, ferrous sulfate dosimeter solution, polystyrene and PMMA, 0.5% for water-to-silicon and 1% for water-to-air and water-to-photographic-film materials.	Water	139-144	LIF interleukin 6 family cytokine	Homo sapiens	148-151
10477169-7	1999	injections of the water-soluble H10-HCl decrease the growth of solid tumors in mice inoculated s.c. with Lewis lung carcinoma.	Water	18-23	histocompatibility 10	Mus musculus	32-35
25662477-11	2015	CONCLUSIONS: Taken together these results provide a possible molecular mechanism explaining the increased AQP2 membrane expression under RGZ treatment: in renal cells RGZ elicits Ca(2+) transients facilitating AQP2 exposure at the apical plasma membrane, thus increasing collecting duct water permeability.	Water	287-292	aquaporin 2	Homo sapiens	210-214
25998606-7	2015	RESULTS: Chimeric AQP2 expressed in mpkCCD cell conferred osmotic water permeability to the cells.	Water	66-71	aquaporin 2	Mus musculus	18-22
9718307-11	1998	The results of the present study suggest for the first time that the beta5" loop from the C-terminal domain may be involved in the interaction of HPL with a lipid/water interface.	Water	163-168	galectin 1	Homo sapiens	146-149
9718321-11	1998	These observations may provide a further clue to the mechanism of the conformational change of domain III of annexin V induced by high calcium concentrations and interaction at the membrane/water interface.	Water	190-195	annexin A5	Homo sapiens	109-118
25523423-4	2015	Compared to wild-type (WT) mice, APP/PS1 mice showed significant delays in learning the location of a submerged platform in the Morris water maze.	Water	135-140	presenilin 1	Mus musculus	37-40
9726824-8	1998	In addition, in mice developing EAU, which does not have an abrupt onset as it does in rats and may involve neovascularization, a comparable upregulation of VEGF in the inner retina to that seen in rats developing EAU occurs with no increase in TGFbeta1 or TGFbeta2.	Water	32-35	vascular endothelial growth factor A	Rattus norvegicus	157-161
9726824-8	1998	In addition, in mice developing EAU, which does not have an abrupt onset as it does in rats and may involve neovascularization, a comparable upregulation of VEGF in the inner retina to that seen in rats developing EAU occurs with no increase in TGFbeta1 or TGFbeta2.	Water	214-217	vascular endothelial growth factor A	Rattus norvegicus	157-161
10412555-4	1999	Exposure to aluminum sulfate in drinking water inhibited ALA-D activity in kidney (23.3 +/- 3.7%, mean +/- SEM, P &lt; 0.05 compared to control), but enhanced it in liver (31.2 +/- 15.0%, mean +/- SEM, P &lt; 0.05).	Water	41-46	aminolevulinate, delta-, dehydratase	Mus musculus	57-62
26508977-2	2015	In this study we evaluated the effect of the water extract of a mixture of A. iwayomogi and C. longa (ACE) on high-fat diet-induced metabolic syndrome in a mouse model.	Water	45-50	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	102-105
10334581-6	1999	Brookhaven National Laboratory prepared a National Institute of Standards and Technology traceable 90Sr tap-water sample used to quantify test method biases.	Water	108-113	filamin B	Homo sapiens	104-107
9675160-6	1998	Hydration fingerprints of antithrombin (that is, water-permeable pockets) are analyzed to determine their location, volume, and size of access pores, using alpha shape-based methods from computational geometry.	Water	49-54	serpin family C member 1	Homo sapiens	26-38
9675160-11	1998	This study demonstrates that conformational changes of antithrombin, including loop insertion, are linked to water transfer from antithrombin to bulk solution.	Water	109-114	serpin family C member 1	Homo sapiens	55-67
9675160-11	1998	This study demonstrates that conformational changes of antithrombin, including loop insertion, are linked to water transfer from antithrombin to bulk solution.	Water	109-114	serpin family C member 1	Homo sapiens	129-141
25277410-10	2015	Induction of colitis and water avoidance stress increased levels of Mir29a and Mir29b and intestinal permeability in wild-type mice; these increased intestinal permeability in colons of far fewer Mir29(-/-) mice.	Water	25-30	microRNA 29a	Homo sapiens	68-73
9757370-6	1998	Only AQP2, the vasopressin-sensitive water channel in the kidney, which is mutated in autosomal recessive and dominant cases of nephrogenic diabetes insipidus, has been shown to be involved in human disease.	Water	37-42	aquaporin 2	Homo sapiens	5-9
10412857-1	1999	The aim of this study was to test the hypothesis that the relative insensitivity of the ovine fetal kidney to arginine vasopressin (AVP) is due to low levels of expression of the gene for aquaporin-2 (AQP2) which encodes the AVP-regulated water channel.	Water	239-244	aquaporin 2	Homo sapiens	188-199
10412857-1	1999	The aim of this study was to test the hypothesis that the relative insensitivity of the ovine fetal kidney to arginine vasopressin (AVP) is due to low levels of expression of the gene for aquaporin-2 (AQP2) which encodes the AVP-regulated water channel.	Water	239-244	aquaporin 2	Homo sapiens	201-205
10099631-0	1999	Influence of water activity on the enantioselective esterification of (R,S)-ibuprofen by Candida antarctica lipase B in solventless media.	Water	13-18	PAN0_003d1715	Moesziomyces antarcticus	108-114
24920077-9	2015	Our data indicate that C1q is present in the skin mucus of the Siberian sturgeon to protect against water-borne bacteria, and the C1qC found in the sturgeon may represent the primitive form of teleost and tetrapod C1qCs.	Water	100-105	complement C1q A chain	Homo sapiens	23-26
10421435-11	1999	Our results support the conclusion that D70 and E197 are major residues for the water/H-bond network dynamics in the active site gorge of BuChE, both residues acting like valves.	Water	80-85	butyrylcholinesterase	Homo sapiens	138-143
9701581-4	1998	In addition to proteins already known to be involved in the response to water stress (e.g. RAB17 [Responsive to ABA]), several enzymes involved in basic metabolic cellular pathways such as glycolysis and the Krebs cycle (e.g. enolase and triose phosphate isomerase) were identified, as well as several others, including caffeate O-methyltransferase, the induction of which could be related to lignification.	Water	73-78	dehydrin DHN1	Zea mays	92-97
24436256-1	2015	PURPOSE: To investigate the effect of Carr-Purcell (CP) pulse trains on transverse relaxation times, T2, of tissue water and metabolites (both noncoupled and J-coupled spins) in the rat brain at 9.4 Tesla (T) using LASER, CP-LASER, and T2rho-LASER sequences.	Water	115-120	arrestin 3	Rattus norvegicus	38-42
9771407-3	1998	METHODS: TGF-alpha overexpression was induced in transgenic mice by ZnSO4 administration in drinking water (TG+).	Water	101-106	transforming growth factor alpha	Mus musculus	9-18
9649557-0	1998	An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex.	Water	15-20	aquaporin 2	Homo sapiens	3-14
9649557-4	1998	In contrast to wild-type AQP2, AQP2-E258K conferred a small increase in water permeability, caused by a reduced expression at the plasma membrane.	Water	72-77	aquaporin 2	Homo sapiens	31-35
10228154-7	1999	Since an AQP monomer is the functional unit and AQP2-E258K is a functional but misrouted water channel, heterotetramerization of AQP2-E258K with wild-type AQP2 and inhibition of further routing of this complex to the plasma membrane is the cause of dominant NDI.	Water	89-94	aquaporin 2	Homo sapiens	48-52
9649557-5	1998	Coexpression of wild-type AQP2 with AQP2-E258K, but not with an AQP2 mutant in recessive NDI (AQP2-R187C), revealed a dominant-negative effect on the water permeability conferred by wild-type AQP2.	Water	150-155	aquaporin 2	Homo sapiens	26-30
9649557-5	1998	Coexpression of wild-type AQP2 with AQP2-E258K, but not with an AQP2 mutant in recessive NDI (AQP2-R187C), revealed a dominant-negative effect on the water permeability conferred by wild-type AQP2.	Water	150-155	aquaporin 2	Homo sapiens	36-40
9649557-5	1998	Coexpression of wild-type AQP2 with AQP2-E258K, but not with an AQP2 mutant in recessive NDI (AQP2-R187C), revealed a dominant-negative effect on the water permeability conferred by wild-type AQP2.	Water	150-155	aquaporin 2	Homo sapiens	36-40
9649557-5	1998	Coexpression of wild-type AQP2 with AQP2-E258K, but not with an AQP2 mutant in recessive NDI (AQP2-R187C), revealed a dominant-negative effect on the water permeability conferred by wild-type AQP2.	Water	150-155	aquaporin 2	Homo sapiens	36-40
9649557-5	1998	Coexpression of wild-type AQP2 with AQP2-E258K, but not with an AQP2 mutant in recessive NDI (AQP2-R187C), revealed a dominant-negative effect on the water permeability conferred by wild-type AQP2.	Water	150-155	aquaporin 2	Homo sapiens	36-40
10198223-4	1999	Such adamantyl conjugates derived from Gb3 showed significantly enhanced solubility in water compared to natural Gb3.	Water	87-92	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	39-42
25461193-9	2015	Additionally, in a medial frontal cortex voxel (15 mul), SR-/- mice exhibited significantly higher glutamate/water (12%, t=1.83, p&lt;0.05) and GABA/water (72%, t=4.10, p&lt;0.001) ratios.	Water	109-114	serine racemase	Mus musculus	57-59
9648076-8	1998	There was also a large decrease in outer medullary expression of two collecting duct water channels (aquaporin-2 and -3) and the major water channel of the thin descending limb of Henle"s loop (aquaporin-1).	Water	85-90	aquaporin 2	Rattus norvegicus	101-119
25461193-9	2015	Additionally, in a medial frontal cortex voxel (15 mul), SR-/- mice exhibited significantly higher glutamate/water (12%, t=1.83, p&lt;0.05) and GABA/water (72%, t=4.10, p&lt;0.001) ratios.	Water	149-154	serine racemase	Mus musculus	57-59
26004101-0	2015	Ag@Au core-shell nanoparticles synthesized by pulsed laser ablation in water: Effect of plasmon coupling and their SERS performance.	Water	71-76	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	115-119
9609747-8	1998	Exposure to ambient 21% O2 may contribute to increases in AQP-4 and ENaC expression to facilitate water transport across neonatal airway epithelia in the immediate postnatal period.	Water	98-103	aquaporin 4	Rattus norvegicus	58-63
10205232-7	1999	Enhanced urinary sodium (1650+/-370% versus 450+/-150%, P=0.01), cGMP, and water excretions were observed in Htx and urinary cGMP positively correlated with natriuresis in 6 of the Htx subjects.	Water	75-80	Zic family member 3	Homo sapiens	109-112
25407336-1	2014	The electrocatalytic proton reduction activity of a Ni bis(diphosphine) (NiP) and a cobaloxime (CoP) catalyst has been studied in water in the presence of the gaseous inhibitors O2 and CO.	Water	130-135	caspase recruitment domain family member 16	Homo sapiens	96-99
10353318-3	1999	The sialidase-treated LPL showed unchanged hydrolyzing activity for tributyrin, a water-soluble substrate of esterase, compared with the untreated LPL.	Water	82-87	lipoprotein lipase	Homo sapiens	22-25
9785103-6	1998	Analysis of UcP emission decays, measured by time-correlated-single-photon-counting, yielded components 0.4-0.6 ns, 2.2-3 ns and 9-10 ns (or alternatively 0.1, 1.5, 4.3 and 12.2 ns; or 0.1-0.3, 1.2, 3.7 and 10.5 ns), very similar to those of free tryptophan in water, where the longest component belongs to anionic form.	Water	261-266	uncoupling protein 1	Homo sapiens	12-15
25358848-0	2014	Graphene-CdS quantum dots-polyoxometalate composite films for efficient photoelectrochemical water splitting and pollutant degradation.	Water	93-98	CDP-diacylglycerol synthase 1	Homo sapiens	9-12
9680059-3	1998	HMQC NOESY spectra of the labelled Leu-enkephalin in a DMSOd6/H2O) mixture at 275 K do show numerous NOEs, but these are not consistent with a single conformer and are only sufficient to describe the conformational state as a mixture of several conformers.	Water	62-65	prodynorphin	Homo sapiens	35-49
10097052-10	1999	The vulnerability of gas hydrate to temperature and sea level changes enhances the instability of deep-water oceanic sediments, and thus human activities and installations in this setting can be affected.	Water	103-108	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	52-55
9600591-4	1998	By contrast, in animals with deposits containing Abeta 1-28, Abeta 1-42 or water, neuronal degeneration or depletion only occurred in a reduced area around the place where the implant needle penetrated the CA1 subfield.	Water	75-80	carbonic anhydrase 1	Rattus norvegicus	206-209
25319078-0	2014	A fluorescent and colorimetric sensor for nanomolar detection of Co2+ in water.	Water	73-78	complement C2	Homo sapiens	65-68
10070156-2	1999	The study of the mechanisms involved in the regulation of collecting duct water permeability, in particular, has advanced very rapidly since the identification and characterization of aquaporin-2 (AQP2) in 1993.	Water	74-79	aquaporin 2	Homo sapiens	184-195
10070156-2	1999	The study of the mechanisms involved in the regulation of collecting duct water permeability, in particular, has advanced very rapidly since the identification and characterization of aquaporin-2 (AQP2) in 1993.	Water	74-79	aquaporin 2	Homo sapiens	197-201
9593799-0	1998	Water-deprived white-footed mice express c-fos on a day/night cycle graded according to the duration of deprivation.	Water	0-5	FBJ osteosarcoma oncogene	Mus musculus	41-46
25502280-0	2014	Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer"s disease.	Water	20-25	presenilin 1	Mus musculus	72-75
9593799-4	1998	During the dark period, when these animals are normally active, 6 h of water deprivation produced near-maximal increases in the number of cells positive for Fos-LIR in the SON and PVN.	Water	71-76	FBJ osteosarcoma oncogene	Mus musculus	157-160
9593799-6	1998	During the day, it required as much as 12 h of water deprivation to produce increases in Fos-LIR cells approaching those achieved at night.	Water	47-52	FBJ osteosarcoma oncogene	Mus musculus	89-92
9593799-9	1998	Our results show (1) that biologically reasonable levels of water restriction (and resulting changes in blood osmolarity) induce changes in Fos-LIR in this wild mouse species, and (2) that these mice have a daily cycle of sensitivity to water deprivation that is demonstrated by both behavioral, psychological and immunohistological assessment of reactions to water deprivation.	Water	60-65	FBJ osteosarcoma oncogene	Mus musculus	140-143
9950932-6	1999	Subcutaneous injections of 40 nmol of amylin significantly increased water intake in euhydrated rats, as did an equimolar dose of ANG II, which is a well-described SFO-mediated effect of circulating ANG II.	Water	69-74	islet amyloid polypeptide	Rattus norvegicus	38-44
9950948-1	1999	In the renal collecting duct, vasopressin acutely activates cAMP production, resulting in trafficking of aquaporin-2 water channels (AQP2) to the apical plasma membrane, thereby increasing water permeability.	Water	117-122	aquaporin 2	Mus musculus	105-116
9950948-1	1999	In the renal collecting duct, vasopressin acutely activates cAMP production, resulting in trafficking of aquaporin-2 water channels (AQP2) to the apical plasma membrane, thereby increasing water permeability.	Water	117-122	aquaporin 2	Mus musculus	133-137
25407689-6	2014	Furthermore, the heat capacity changes (DeltaCp ) associated with the ligand binding to HDAC8 markedly differed from one SAHA analogue to the other, and such features could primarily be rationalized in light of the dynamic flexibility in the enzyme structure in conjunction with the reorganization of the active site resident water molecules.	Water	326-331	histone deacetylase 8	Homo sapiens	88-93
10069656-0	1999	Aquaporin-2 water channel mutations and nephrogenic diabetes insipidus: new variations on a theme.	Water	12-17	aquaporin 2	Homo sapiens	0-11
9570029-1	1998	Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel of the renal collecting duct and is excreted in human urine.	Water	47-52	aquaporin 2	Homo sapiens	0-11
26583226-1	2014	This work presents a systematic investigation into the basis set convergence of harmonic vibrational frequencies of (H2O)2 and (HF)2 computed with second-order Moller-Plesset perturbation theory (MP2) and the coupled-cluster singles and doubles method with perturbative connected triples, CCSD(T), while employing correlation-consistent basis sets as large as aug-cc-pV6Z.	Water	117-120	tryptase pseudogene 1	Homo sapiens	196-199
16349537-1	1998	Hyphomonas strain MHS-3, a member of a genus of primary colonizers of surfaces immersed in marine water, synthesizes two structures that mediate adhesion to solid substrata, namely, capsular exopolysaccharide and fimbriae.	Water	98-103	MHS3	Homo sapiens	18-23
24641113-7	2014	Repeated injections of hAMS (15 min, 48 h and 7 d post-exposure) decreased significantly the area of the wounds and improved the integrity of the barrier function as expressed by measuring trans-epidermal water loss up to 10 d. CONCLUSIONS: Our results indicate that the role of macrophages in wound healing is complex; their efficacy may depend on the timing of administration.	Water	205-210	twist family bHLH transcription factor 2	Homo sapiens	23-27
9551433-0	1998	Role of aquaporin-2 water channels in urinary concentration and dilution defects.	Water	20-25	aquaporin 2	Homo sapiens	8-19
9724927-1	1998	Nonionic and anionic water-soluble amphiphiles were shown to increase strongly the binding of fluorescein isothiocyanate-conjugated annexin V (FITC-annexin V) in human erythrocytes pretreated with the aminophospholipid translocase (APLT) inhibitor n-ethylmaleimide (NEM).	Water	21-26	annexin A5	Homo sapiens	132-141
9724927-1	1998	Nonionic and anionic water-soluble amphiphiles were shown to increase strongly the binding of fluorescein isothiocyanate-conjugated annexin V (FITC-annexin V) in human erythrocytes pretreated with the aminophospholipid translocase (APLT) inhibitor n-ethylmaleimide (NEM).	Water	21-26	annexin A5	Homo sapiens	148-157
9932870-2	1999	The regulation of AQP4 is believed to be important for the homeostasis of water in the brain, but the AQP4 regulatory mechanisms are not yet known.	Water	74-79	aquaporin 4	Rattus norvegicus	18-22
25450461-0	2014	The AQP-3 water channel and the ClC-3 chloride channel coordinate the hypotonicity-induced swelling volume in nasopharyngeal carcinoma cells.	Water	10-15	aquaporin 3 (Gill blood group)	Homo sapiens	4-9
9882456-0	1999	Quantitative differences in the active-site hydrophobicity of five human glutathione S-transferase isoenzymes: water-soluble carcinogen-selective properties of the neoplastic GSTP1-1 species.	Water	111-116	glutathione S-transferase pi 1	Homo sapiens	175-182
9494110-5	1998	We find that CD38-catalysed cleavage of the nicotinamide-ribose bond results in the formation of an E.ADP-ribosyl intermediary complex, which is common to all reaction pathways; this intermediate reacts (1) with acceptors such as water (hydrolysis), methanol (methanolysis) or pyridine (transglycosidation), and (2) intramolecularly, yielding cyclic ADP-ribose with a low efficiency.	Water	230-235	CD38 molecule	Homo sapiens	13-17
25450461-11	2014	The opening of ClC-3 transports Cl(-) across the cell membrane and then drives the efflux of water through AQP-3 channels and ion channels; AQP-3 may interact with ClC-3 in order to regulate the effluxes of chloride and water.	Water	93-98	chloride voltage-gated channel 3	Homo sapiens	15-20
25450461-11	2014	The opening of ClC-3 transports Cl(-) across the cell membrane and then drives the efflux of water through AQP-3 channels and ion channels; AQP-3 may interact with ClC-3 in order to regulate the effluxes of chloride and water.	Water	93-98	aquaporin 3 (Gill blood group)	Homo sapiens	107-112
10331078-1	1999	Cytochrome P4501A1 is a substrate-inducible microsomal enzyme that oxygenates polycyclic aromatic hydrocarbons, such as the carcinogen benzo(a)pyrene, as the initial step in their metabolic processing to water-soluble derivatives.	Water	204-209	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-18
25450461-11	2014	The opening of ClC-3 transports Cl(-) across the cell membrane and then drives the efflux of water through AQP-3 channels and ion channels; AQP-3 may interact with ClC-3 in order to regulate the effluxes of chloride and water.	Water	93-98	aquaporin 3 (Gill blood group)	Homo sapiens	140-145
9486978-0	1998	Upregulation of aquaporin 2 water channel expression in pregnant rats.	Water	28-33	aquaporin 2	Rattus norvegicus	16-27
25450461-11	2014	The opening of ClC-3 transports Cl(-) across the cell membrane and then drives the efflux of water through AQP-3 channels and ion channels; AQP-3 may interact with ClC-3 in order to regulate the effluxes of chloride and water.	Water	93-98	chloride voltage-gated channel 3	Homo sapiens	164-169
9486978-2	1998	The collecting duct water channel, aquaporin 2 (AQP2), plays a pivotal role in the renal water regulation, and we hypothesized that AQP2 expression could be modified during pregnancy.	Water	20-25	aquaporin 2	Rattus norvegicus	35-46
25450461-11	2014	The opening of ClC-3 transports Cl(-) across the cell membrane and then drives the efflux of water through AQP-3 channels and ion channels; AQP-3 may interact with ClC-3 in order to regulate the effluxes of chloride and water.	Water	220-225	chloride voltage-gated channel 3	Homo sapiens	15-20
9486978-2	1998	The collecting duct water channel, aquaporin 2 (AQP2), plays a pivotal role in the renal water regulation, and we hypothesized that AQP2 expression could be modified during pregnancy.	Water	20-25	aquaporin 2	Rattus norvegicus	48-52
9486978-2	1998	The collecting duct water channel, aquaporin 2 (AQP2), plays a pivotal role in the renal water regulation, and we hypothesized that AQP2 expression could be modified during pregnancy.	Water	20-25	aquaporin 2	Rattus norvegicus	132-136
10210165-1	1999	Tyrosine hydroxylase (TH) activity, the rate-limiting step in the synthesis of catecholamines, was quantified in the preoptic area-hypothalamus of adult male Japanese quail by a new assay measuring the tritiated water production from 3,5-[3H]-L-tyrosine.	Water	212-217	tyrosine 3-monooxygenase	Coturnix japonica	0-20
9486978-2	1998	The collecting duct water channel, aquaporin 2 (AQP2), plays a pivotal role in the renal water regulation, and we hypothesized that AQP2 expression could be modified during pregnancy.	Water	89-94	aquaporin 2	Rattus norvegicus	35-46
25450461-11	2014	The opening of ClC-3 transports Cl(-) across the cell membrane and then drives the efflux of water through AQP-3 channels and ion channels; AQP-3 may interact with ClC-3 in order to regulate the effluxes of chloride and water.	Water	220-225	aquaporin 3 (Gill blood group)	Homo sapiens	107-112
9486978-2	1998	The collecting duct water channel, aquaporin 2 (AQP2), plays a pivotal role in the renal water regulation, and we hypothesized that AQP2 expression could be modified during pregnancy.	Water	89-94	aquaporin 2	Rattus norvegicus	48-52
9486978-14	1998	The results of the study indicate that upregulation of AQP2 contributes to the water retention in pregnancy through a V2 receptor-mediated effect.	Water	79-84	aquaporin 2	Rattus norvegicus	55-59
10210165-1	1999	Tyrosine hydroxylase (TH) activity, the rate-limiting step in the synthesis of catecholamines, was quantified in the preoptic area-hypothalamus of adult male Japanese quail by a new assay measuring the tritiated water production from 3,5-[3H]-L-tyrosine.	Water	212-217	tyrosine 3-monooxygenase	Coturnix japonica	22-24
25450461-11	2014	The opening of ClC-3 transports Cl(-) across the cell membrane and then drives the efflux of water through AQP-3 channels and ion channels; AQP-3 may interact with ClC-3 in order to regulate the effluxes of chloride and water.	Water	220-225	aquaporin 3 (Gill blood group)	Homo sapiens	140-145
25450461-11	2014	The opening of ClC-3 transports Cl(-) across the cell membrane and then drives the efflux of water through AQP-3 channels and ion channels; AQP-3 may interact with ClC-3 in order to regulate the effluxes of chloride and water.	Water	220-225	chloride voltage-gated channel 3	Homo sapiens	164-169
25538184-8	2014	Coexpression of TSPO and PIP2;7 resulted in decreased levels of PIP2;7 in the plasma membrane and abolished the membrane water permeability mediated by transgenic PIP2;7.	Water	121-126	TSPO(outer membrane tryptophan-rich sensory protein)-like protein	Arabidopsis thaliana	16-20
10457325-10	1999	These findings indicate regional variations in expression of the AQP3 water channel in mucosa of the small intestine.	Water	70-75	aquaporin 3 (Gill blood group)	Rattus norvegicus	65-69
9486145-9	1998	When we injected oocytes with AQP1 cRNA and then CA, the CO2-induced pHi changes in these AQP1/CA oocytes were approximately 40% faster than in the water/CA oocytes (75 x 10(-4) pH units/s), and ETX reduced the rates substantially (14.7 x 10(-4) pH units/s).	Water	148-153	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	30-34
9494740-2	1998	In Part I, 6 skiers drank water ad libitum during ski training.	Water	26-31	SKI proto-oncogene	Homo sapiens	13-16
25538184-8	2014	Coexpression of TSPO and PIP2;7 resulted in decreased levels of PIP2;7 in the plasma membrane and abolished the membrane water permeability mediated by transgenic PIP2;7.	Water	121-126	plasma membrane intrinsic protein 3	Arabidopsis thaliana	25-31
9474026-3	1998	Protonation of the carbanion by water selectively produced LSD.	Water	32-37	deoxyribonuclease 1 like 3	Homo sapiens	59-62
25342030-9	2014	Administration of recombinant human MFGE8 decreased brain water content and improved neurological functions both at 24 hours and at 72 hours after SAH.	Water	58-63	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	36-41
10234910-13	1999	It was established that maximal informativevalue of myoglobin study was achieved in patients at the stages of water-electrolyte balance disturbances, in peritonitis and polyorganic insufficiency.	Water	110-115	myoglobin	Homo sapiens	52-61
25413317-5	2014	Q-PCR analysis of microdissected CD of water-deprived mice revealed increased aquaporin-2 (AQP2) expression in outer medullary and cortical CD while ENaC abundance decreased in outer medullary but not cortical CD.	Water	39-44	aquaporin 2	Mus musculus	78-89
9950292-2	1999	Molecular mobility as determined by NMR relaxation-based critical temperature of molecular mobility (Tmc) and glass transition temperature (Tg) is discussed in relation to the plasticizing effect of water in formulations.	Water	199-204	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	101-104
9950292-6	1999	Tmc increased as the ratio of bound water to mobile water increased and as the molecular mobility of mobile water decreased.	Water	36-41	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	0-3
9950292-6	1999	Tmc increased as the ratio of bound water to mobile water increased and as the molecular mobility of mobile water decreased.	Water	52-57	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	0-3
9950292-6	1999	Tmc increased as the ratio of bound water to mobile water increased and as the molecular mobility of mobile water decreased.	Water	52-57	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	0-3
9950292-7	1999	The formulation containing MC exhibited a lower Tmc than the formulation containing dextran because of the smaller ratio of bound water and the higher molecular mobility of mobile water.	Water	130-135	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	48-51
9950292-7	1999	The formulation containing MC exhibited a lower Tmc than the formulation containing dextran because of the smaller ratio of bound water and the higher molecular mobility of mobile water.	Water	180-185	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	48-51
9449630-9	1998	After injection of oocytes with copy RNA coding for rat type I iodothyronine deiodinase, we found an increase in iodide production from rT3 from 2.3% (water-injected oocytes) to 46.2% accompanied by a reciprocal decrease in rT3 sulfate accumulation from 53.7% to 7.1%.	Water	151-156	iodothyronine deiodinase 1	Rattus norvegicus	56-87
9699412-1	1998	The results of interaction of the bile salts sodium dehydrocholate (NaDHC) and sodium cholate (NaC) with the water soluble polymer polyvinyl pyrrolidone (PVP) studied by the methods of conductance, surface tension, viscosity and calorimetry are reported.	Water	109-114	synuclein alpha	Homo sapiens	95-98
9950292-8	1999	The Tmc of the formulation containing PVP was higher than that expected from the higher T2 values of water because of the lower molecular mobility of mobile water regardless of the higher ratio of mobile water.	Water	101-106	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	4-7
25413317-5	2014	Q-PCR analysis of microdissected CD of water-deprived mice revealed increased aquaporin-2 (AQP2) expression in outer medullary and cortical CD while ENaC abundance decreased in outer medullary but not cortical CD.	Water	39-44	aquaporin 2	Mus musculus	91-95
9950292-8	1999	The Tmc of the formulation containing PVP was higher than that expected from the higher T2 values of water because of the lower molecular mobility of mobile water regardless of the higher ratio of mobile water.	Water	157-162	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	4-7
9950292-8	1999	The Tmc of the formulation containing PVP was higher than that expected from the higher T2 values of water because of the lower molecular mobility of mobile water regardless of the higher ratio of mobile water.	Water	157-162	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	4-7
25413317-5	2014	Q-PCR analysis of microdissected CD of water-deprived mice revealed increased aquaporin-2 (AQP2) expression in outer medullary and cortical CD while ENaC abundance decreased in outer medullary but not cortical CD.	Water	39-44	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	149-153
25368148-3	2014	Here we estimated CaCO3 precipitation rates in the surface water of the Red Sea from total alkalinity depletion along their axial flow using the water flux in the straits of Bab el Mandeb.	Water	59-64	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
10444989-2	1999	It began in 1988 in Goemar"s "Laboratory of the Sea", with an original idea of making a product manufactured from sea water and transforming it into an isotonic solution, while preserving all the elements of natural sea water, specially the trace elements and the alkaline PH.	Water	118-123	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	48-51
10444989-2	1999	It began in 1988 in Goemar"s "Laboratory of the Sea", with an original idea of making a product manufactured from sea water and transforming it into an isotonic solution, while preserving all the elements of natural sea water, specially the trace elements and the alkaline PH.	Water	118-123	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	114-117
10026831-10	1998	Additional studies have indicated that the observed down-regulation of aquaporin-2 expression also occurs in the renal cortex as well as the inner and outer medullas, and can be reversed simply by water restriction despite maintenance of hyponatremia.	Water	197-202	aquaporin 2	Rattus norvegicus	71-82
10026831-11	1998	Our results therefore suggest that escape from vasopressin-induced antidiuresis is attributable, at least in part, to a vasopressin-independent and osmolality-independent decrease in aquaporin-2 water channel expression in the renal collecting duct.	Water	195-200	aquaporin 2	Rattus norvegicus	183-194
10026833-10	1998	Thus, non-osmotic release of AVP in CHF upregulates AQP2 water channels, enhances water reabsorption and causes hyponatremia.	Water	57-62	aquaporin 2	Homo sapiens	52-56
9558461-6	1998	Aquaporin-2 is a vasopressin-regulated water channel located in the apical membrane, and aquaporin-3 is a constitutive water channel located in the basolateral membrane.	Water	39-44	aquaporin 2	Homo sapiens	0-11
9558461-6	1998	Aquaporin-2 is a vasopressin-regulated water channel located in the apical membrane, and aquaporin-3 is a constitutive water channel located in the basolateral membrane.	Water	119-124	aquaporin 3 (Gill blood group)	Homo sapiens	89-100
24928379-4	2014	The model is developed using the HP1 code, which couples HYDRUS-1D for the water flow and solute transport to PHREEQC for geochemical reactions.	Water	75-80	chromobox 5	Homo sapiens	33-36
9442361-0	1998	Physiology and pathophysiology of the aquaporin-2 water channel.	Water	50-55	aquaporin 2	Homo sapiens	38-49
9990364-3	1998	The purpose of the present study was to determine the effect of natural sunlight combined with salt water bathing in the Dead Sea on the methionine-enkephalin (e.n.k.)	Water	100-105	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	126-129
25138278-5	2014	The diatoms, which are phylogenetically associated to the Navicula genus, grew in culture at salinities up to 40 % Dead Sea water (DSW) (14 % total dissolved salts, TDS).	Water	124-129	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	120-123
9848772-3	1998	Dysregulation of aquaporin-2 (AQP2), the predominant vasopressin-regulated water channel, is known to be associated with a range of congenital and acquired water balance disorders including nephrogenic diabetes insipidus and states of water retention.	Water	156-161	aquaporin 2	Rattus norvegicus	17-28
9848772-3	1998	Dysregulation of aquaporin-2 (AQP2), the predominant vasopressin-regulated water channel, is known to be associated with a range of congenital and acquired water balance disorders including nephrogenic diabetes insipidus and states of water retention.	Water	156-161	aquaporin 2	Rattus norvegicus	30-34
9511860-3	1998	In our studies, capillary electrophoresis (CE) was used for the analysis of water-soluble fountain pen inks.	Water	76-81	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	99-102
25039825-2	2014	A working solution of a water/glycerol emulsion and butylene glycol is applied to thermal paper by means of either a vinyl stamp and pad, or a marker pen.	Water	24-29	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	150-153
9824541-5	1998	Aquaporin-2 is the only water channel that is activated by vasopressin to enhance water reabsorption in the kidney collecting duct.	Water	24-29	aquaporin 2	Homo sapiens	0-11
9824541-5	1998	Aquaporin-2 is the only water channel that is activated by vasopressin to enhance water reabsorption in the kidney collecting duct.	Water	82-87	aquaporin 2	Homo sapiens	0-11
9824541-6	1998	Aquaporin-3 also contributes to water reabsorption in the kidney collecting duct but is unresponsive to vasopressin.	Water	32-37	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
9824541-10	1998	Although the exact function of aquaporin-6 is not known due to its uncertain localization, its restricted presence in the kidney may suggest a potential role in water transport.	Water	161-166	aquaporin 6	Homo sapiens	31-42
9822111-5	1998	Acutely, vasopressin induces exocytic insertion of AQP2 into the apical plasma membrane to increase collecting duct water reabsorption.	Water	116-121	aquaporin 2	Homo sapiens	51-55
9822112-0	1998	Vasopressin type-2 receptor and aquaporin-2 water channel mutants in nephrogenic diabetes insipidus.	Water	44-49	aquaporin 2	Homo sapiens	32-43
9466840-0	1998	Reverse Micelle Systems Composed of Water, Triton X-100, and Phospholipids in Organic Solvents Catalysis, stability, and thermostability of yeast hexokinase were determined in the microenvironments of two organic solvent/Triton X-100/phospholipids systems.	Water	36-41	hexokinase	Saccharomyces cerevisiae S288C	146-156
25127614-6	2014	Finally, the DGT device using the P81 as the binding layer was applied for in situ measurements of Hg in river water.	Water	111-116	ezrin	Homo sapiens	34-37
9715047-0	1998	Adaptation to water depletion in the newborn rat--immunocytochemical localization of aquaporin-2.	Water	14-19	aquaporin 2	Rattus norvegicus	85-96
9822112-2	1998	This process predominantly occurs in renal collecting duct cells, where transcellular water reabsorption is induced after binding of the pituitary hormone arginine-vasopressin to its vasopressin type-2 receptor and the subsequent insertion of aquaporin-2 (AQP2) water channels in the apical membrane of these cells.	Water	86-91	aquaporin 2	Homo sapiens	243-254
9822112-2	1998	This process predominantly occurs in renal collecting duct cells, where transcellular water reabsorption is induced after binding of the pituitary hormone arginine-vasopressin to its vasopressin type-2 receptor and the subsequent insertion of aquaporin-2 (AQP2) water channels in the apical membrane of these cells.	Water	86-91	aquaporin 2	Homo sapiens	256-260
9822112-2	1998	This process predominantly occurs in renal collecting duct cells, where transcellular water reabsorption is induced after binding of the pituitary hormone arginine-vasopressin to its vasopressin type-2 receptor and the subsequent insertion of aquaporin-2 (AQP2) water channels in the apical membrane of these cells.	Water	262-267	aquaporin 2	Homo sapiens	243-254
25362296-3	2014	The MTA-MP2 optimized cluster geometries, constructed from the fragments, were found to be within &lt;0.5 kcal/mol from the minimum geometries obtained from the MP2 optimization of the entire (H2O)25 cluster.	Water	193-196	tryptase pseudogene 1	Homo sapiens	8-11
9815132-1	1998	Vesicle targeting proteins ("SNAREs") have been proposed to direct vasopressin-induced trafficking of aquaporin-2 water channels in kidney collecting ducts.	Water	114-119	aquaporin 2	Rattus norvegicus	102-113
9496709-2	1998	AVP regulates the water channel (aquaporin-2:AQP2) through V2 receptors and increases the water permeability of the collecting duct.	Water	18-23	aquaporin 2	Rattus norvegicus	33-44
9496709-2	1998	AVP regulates the water channel (aquaporin-2:AQP2) through V2 receptors and increases the water permeability of the collecting duct.	Water	18-23	aquaporin 2	Rattus norvegicus	45-49
25362296-3	2014	The MTA-MP2 optimized cluster geometries, constructed from the fragments, were found to be within &lt;0.5 kcal/mol from the minimum geometries obtained from the MP2 optimization of the entire (H2O)25 cluster.	Water	193-196	tryptase pseudogene 1	Homo sapiens	161-164
25209028-0	2014	Enhancement of solar hydrogen evolution from water by surface modification with CdS and TiO2 on porous CuInS2 photocathodes prepared by an electrodeposition-sulfurization method.	Water	45-50	CDP-diacylglycerol synthase 1	Homo sapiens	80-83
9888631-2	1998	Significant increases of alanine amino transferase (ALT) and aspartate amino transferase (AST) were obtained in mice after ingestion of water with forms A and C. The effect on liver was more evident with A than with C. Pyoverdin was purified by means of salt saturation, solvent extractions and ion-exchange chromatography.	Water	136-141	glutamic pyruvic transaminase, soluble	Mus musculus	52-55
9888631-2	1998	Significant increases of alanine amino transferase (ALT) and aspartate amino transferase (AST) were obtained in mice after ingestion of water with forms A and C. The effect on liver was more evident with A than with C. Pyoverdin was purified by means of salt saturation, solvent extractions and ion-exchange chromatography.	Water	136-141	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	61-88
9888631-2	1998	Significant increases of alanine amino transferase (ALT) and aspartate amino transferase (AST) were obtained in mice after ingestion of water with forms A and C. The effect on liver was more evident with A than with C. Pyoverdin was purified by means of salt saturation, solvent extractions and ion-exchange chromatography.	Water	136-141	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	90-93
9496999-3	1997	In theoretical tests, the model shows, for the standard electrode that (a) inside the electrode, any profiles in electrical potential and electrolyte concentration are occurring at the most distal part (approximately 50 microm) of the tip region, (b) asymmetrical shifts in electrolyte concentration just inside the electrode tip opening are the true cause of the electrode"s current rectification, and (c) strong transelectrode currents are producing water flows across the electrode orifice that may affect the volume of smaller and medium-sized cells.	Water	452-457	TOR signaling pathway regulator	Homo sapiens	235-238
9788913-1	1998	We have measured the rebinding of carbon monoxide (CO) to some distal mutants of myoglobin (Mb) in the time range from 10(-8) to 10(-1) s by flash photolysis, in which the photodissociated CO rebinds to the heme iron without escaping to the solvent water from the protein matrix.	Water	249-254	myoglobin	Homo sapiens	81-90
9788913-1	1998	We have measured the rebinding of carbon monoxide (CO) to some distal mutants of myoglobin (Mb) in the time range from 10(-8) to 10(-1) s by flash photolysis, in which the photodissociated CO rebinds to the heme iron without escaping to the solvent water from the protein matrix.	Water	249-254	myoglobin	Homo sapiens	92-94
9878126-8	1998	Expression of mRNAs for IL-1alpha and IL-1beta was observed in the large intestine of mice which received distilled water containing 3% DSS for 5 days.	Water	116-121	interleukin 1 alpha	Mus musculus	24-33
25134491-2	2014	We applied those GNPs for in situ SERS detection of emulsifier molecules within the interfacial region of oil in water (O/W) emulsion systems.	Water	113-118	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	34-38
9421280-4	1997	In a rodent model of acute thermal nociception, the mouse tail immersion test, Dex, in wild type (WT) control animals, produced a dose-dependent increase in the threshold for tail withdrawal from a 52 degrees C water bath with mean ED50 values of 99.9+/-14.5 (alpha2A), 94.6+/-17.8 (alpha2B) and 116.0/-17.1 (alpha2C) microg kg(-1), i.p.	Water	211-216	adrenergic receptor, alpha 2b	Mus musculus	283-290
11536844-7	1997	Solid amorphous CdS generates water soluble beta-sheets, as well.	Water	30-35	CDP-diacylglycerol synthase 1	Homo sapiens	16-19
9778344-7	1998	These interactions coupled with the observation that 2-oxo-3-butynoate is a more potent irreversible inhibitor of 4-oxalocrotonate tautomerase than is 2-OP suggest that Arg-39" and the ordered water molecule polarize the carbonyl group of 2-OP which facilitates a Michael reaction between Pro-1 and the acetylene compound.	Water	193-198	lamin A/C	Homo sapiens	289-294
25136938-1	2014	This work demonstrates the development of a new class of SERS substrates that allows for the simultaneous: (i) filtration of bacteria from any solution (blood, urine, water, or milk), (ii) immobilization of bacteria on the SERS platform, and (iii) enhancing the Raman signal of bacteria.	Water	167-172	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	57-61
25251378-10	2014	The NPC1(NTD) binding pocket is energetically unfavorable to conformational rearrangement of the hydrophobic ligand because it contains more water molecules near the ligand tail and amino acids with polar side chains.	Water	141-146	NPC intracellular cholesterol transporter 1	Homo sapiens	4-8
9799626-10	1998	Taken together, the results indicate that ERalpha activation impairs acquisition of spatial discrimination of the water escape task, but not cue discrimination, in female mice.	Water	114-119	estrogen receptor 1 (alpha)	Mus musculus	42-49
9375354-1	1997	Sorption partition coefficients between water and organic carbon (Koc) for deuterated benzene, toluene, and ethylbenzene have been estimated by measuring values of the octanol-water partition coefficient (Kow) and HPLC retention factors (k1), which correlate closely to values of Koc.	Water	40-45	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	66-69
9375354-1	1997	Sorption partition coefficients between water and organic carbon (Koc) for deuterated benzene, toluene, and ethylbenzene have been estimated by measuring values of the octanol-water partition coefficient (Kow) and HPLC retention factors (k1), which correlate closely to values of Koc.	Water	40-45	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	280-283
9375354-1	1997	Sorption partition coefficients between water and organic carbon (Koc) for deuterated benzene, toluene, and ethylbenzene have been estimated by measuring values of the octanol-water partition coefficient (Kow) and HPLC retention factors (k1), which correlate closely to values of Koc.	Water	176-181	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	66-69
24897129-3	2014	Multiple H-B interaction sites exist in DCO and in its Michael addition product DCOT, which then induce the formation of the H-B complexes with water molecules, DCOH2 and DCOTH4.	Water	144-149	pterin-4 alpha-carbinolamine dehydratase 2	Homo sapiens	161-166
9833669-0	1998	DNA structure and fluctuations sensed from a 1.1ns molecular dynamics trajectory of a fully charged Zif268-DNA complex in water.	Water	122-127	early growth response 1	Homo sapiens	100-106
24897129-4	2014	In the first excited state, the intermolecular H-Bs between water molecule and DCO in DCOH2 are cooperatively and generally strengthened and thus induced the weak fluorescence emission of DCO, while the cooperative H-Bs between water molecule and DCOT in DCOTH4 are overall weakened and thus responsible for the enhanced fluorescence emission of DCOT.	Water	60-65	pterin-4 alpha-carbinolamine dehydratase 2	Homo sapiens	86-91
9367611-6	1997	The temperature coefficients for membrane transport properties were expressed in terms of activation energies for water (ELp) and Me2SO (E omega).	Water	114-119	nuclear receptor subfamily 5 group A member 1	Homo sapiens	121-124
24944200-2	2014	The amount of AQP2 on the plasma membrane is regulated by a balance of exocytosis and endocytosis and is the rate limiting step for water reabsorption in the collecting duct.	Water	132-137	aquaporin 2	Rattus norvegicus	14-18
9751776-1	1998	Aquaporin (AQP) water channels are abundant in the brain and spinal cord, where AQP1 and AQP4 are believed to play major roles in water metabolism and osmoregulation.	Water	16-21	aquaporin 4	Rattus norvegicus	89-93
9751776-1	1998	Aquaporin (AQP) water channels are abundant in the brain and spinal cord, where AQP1 and AQP4 are believed to play major roles in water metabolism and osmoregulation.	Water	130-135	aquaporin 4	Rattus norvegicus	89-93
24835677-0	2014	Characterization of a computationally designed water-soluble human mu-opioid receptor variant using available structural information.	Water	47-52	zeta-chain (TCR) associated protein kinase	Mus musculus	67-85
9729504-1	1998	Urinary concentrating capacity is regulated in part by a long-term adaptational process involving changes in the absolute abundance of the aquaporin-2 water channel in collecting duct cells.	Water	151-156	aquaporin 2	Homo sapiens	139-150
9306020-0	1997	Cystic fibrosis transmembrane conductance regulator activates water conductance in Xenopus oocytes.	Water	62-67	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	0-51
9306020-2	1997	In this context it has been reported that CFTR transports water.	Water	58-63	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	42-46
9306020-3	1997	In the present study we demonstrate that expression of wild-type CFTR (wtCFTR) in Xenopus oocytes and then stimulation by 3-isobutyl-1-methylxanthine (IBMX, 1 mmol/l) activates a Cl- conductance and, in parallel, a water conductance, as measured by a volume increase gravimetrically.	Water	215-220	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	65-69
9306020-4	1997	In water-injected control oocytes or oocytes expressing a mutant form of CFTR (G551D-CFTR) IBMX had very little effect on Cl- conductance and no effect on water conductance.	Water	3-8	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	73-77
9306020-11	1997	Thus, water permeation through wtCFTR probably occurs at a site of CFTR which is spatially apart from the domain responsible for Cl- conductance, or CFTR might be a regulator of an endogenous water channel in oocytes.	Water	6-11	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	33-37
9306020-11	1997	Thus, water permeation through wtCFTR probably occurs at a site of CFTR which is spatially apart from the domain responsible for Cl- conductance, or CFTR might be a regulator of an endogenous water channel in oocytes.	Water	6-11	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	67-71
24835677-1	2014	BACKGROUND: The recent X-ray crystal structure of the murine mu-opioid receptor (MUR) allowed the authors to reengineer a previously designed water-soluble variant of the transmembrane portion of the human MUR (wsMUR-TM).	Water	142-147	zeta-chain (TCR) associated protein kinase	Mus musculus	61-79
9326366-0	1997	ePHOGSY experiments on a paramagnetic protein: location of the catalytic water molecule in the heme crevice of the oxidized form of horse heart cytochrome c.	Water	73-78	cytochrome c, somatic	Equus caballus	144-156
24835677-1	2014	BACKGROUND: The recent X-ray crystal structure of the murine mu-opioid receptor (MUR) allowed the authors to reengineer a previously designed water-soluble variant of the transmembrane portion of the human MUR (wsMUR-TM).	Water	142-147	zeta-chain (TCR) associated protein kinase	Mus musculus	81-84
9745427-0	1998	Novel mutations in aquaporin-2 gene in female siblings with nephrogenic diabetes insipidus: evidence of disrupted water channel function.	Water	114-119	aquaporin 2	Homo sapiens	19-30
24835677-1	2014	BACKGROUND: The recent X-ray crystal structure of the murine mu-opioid receptor (MUR) allowed the authors to reengineer a previously designed water-soluble variant of the transmembrane portion of the human MUR (wsMUR-TM).	Water	142-147	zeta-chain (TCR) associated protein kinase	Mus musculus	206-209
24835677-2	2014	METHODS: The new variant of water-soluble MUR (wsMUR-TM_v2) was engineered based on the murine MUR crystal structure.	Water	28-33	zeta-chain (TCR) associated protein kinase	Mus musculus	42-45
9299432-4	1997	The expression of AQP8 in Xenopus oocytes stimulated the osmotic water permeability (Pr) 8.5 folds.	Water	65-70	hypothetical protein LOC734703 S homeolog	Xenopus laevis	18-22
24835677-2	2014	METHODS: The new variant of water-soluble MUR (wsMUR-TM_v2) was engineered based on the murine MUR crystal structure.	Water	28-33	zeta-chain (TCR) associated protein kinase	Mus musculus	49-52
9774539-2	1998	Rotary-shadowed images of acto-HMM molecules crosslinked using MBS or water-soluble carbodiimide showed that MBS-G-actin binds to the distal half of a myosin head (the region 14-15 nm away from the head-rod junction).	Water	70-75	myosin heavy chain 14	Homo sapiens	151-157
24880143-3	2014	First, immunofluorescence staining was performed to compare the distribution of CD73(+) cells in the retinas of EAU-induced and normal B10RIII mice.	Water	112-115	5' nucleotidase, ecto	Mus musculus	80-84
9736267-11	1998	In summary, AVP-mediated water retention through collecting duct AQP-2 water channels is important in both low-output CF and high-output states such as cirrhosis and pregnancy.	Water	25-30	aquaporin 2	Rattus norvegicus	65-70
9500664-5	1997	(2) The sizes of a part of the nuclei of nerve and glia cells in the area postrema and the brain water content increased by SPX depending on the presence of the pineal, suggesting the pineal"s stimulatory effects on these following SPX.	Water	97-102	spexin hormone	Rattus norvegicus	124-127
24880143-4	2014	The results revealed that a layer of cells in the normal retina that was consistent with the location of retinal pigment epithelial (RPE) cells strongly expressing CD73, and the expression was markedly reduced in the presence of EAU.	Water	229-232	5' nucleotidase, ecto	Mus musculus	164-168
9246049-2	1997	We previously reported that water-immersion stress specifically induced the synthesis of a 60-kDa heat-shock protein (HSP60, chaperonin homolog) in pancreatic cells and preinduction of HSP60 completely prevented development of cerulein-induced pancreatitis in the rat in an HSP60 quantitatively dependent manner.	Water	28-33	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	118-123
25234834-10	2014	These results suggest that SFN affects the water-holding capacity, barrier function and dermal matrix components in photoaging skin.	Water	43-48	stratifin	Homo sapiens	27-30
9246049-2	1997	We previously reported that water-immersion stress specifically induced the synthesis of a 60-kDa heat-shock protein (HSP60, chaperonin homolog) in pancreatic cells and preinduction of HSP60 completely prevented development of cerulein-induced pancreatitis in the rat in an HSP60 quantitatively dependent manner.	Water	28-33	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	185-190
9246049-2	1997	We previously reported that water-immersion stress specifically induced the synthesis of a 60-kDa heat-shock protein (HSP60, chaperonin homolog) in pancreatic cells and preinduction of HSP60 completely prevented development of cerulein-induced pancreatitis in the rat in an HSP60 quantitatively dependent manner.	Water	28-33	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	185-190
10099363-4	1998	As a consequence of both an efficient water trapping and of a gentle dispersion of the immobilized lipase into the reaction medium, the lifetime of the enzyme was significantly prolonged.	Water	39-44	PAN0_003d1715	Moesziomyces antarcticus	100-106
9691020-5	1998	In control experiments, thirsting increased, whereas water loading decreased AQP2 mRNA levels.	Water	53-58	aquaporin 2	Rattus norvegicus	77-81
25273401-1	2014	A simple Ising-like model for the stacking thermodynamics of ice 1 is constructed for nuclei in supercooled water, and combined with classical nucleation theory.	Water	108-113	interactor of little elongation complex ELL subunit 1	Homo sapiens	61-66
9720313-7	1998	The results showed that the reaction of myoglobin with high concentrations of benzyl-ITC in the presence of 8 M urea led to a higher degree of derivatization than in the presence of water only.	Water	182-187	myoglobin	Homo sapiens	40-49
9334905-13	1997	Stable complexes were obtained that could explain the oxidation of the considered substrates by cytochrome P450 1A2 and could offer an insight into the role played by water molecules.	Water	167-172	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	96-115
24956075-0	2014	Eco-directed sustainable prescribing: feasibility for reducing water contamination by drugs.	Water	63-68	ciliogenesis associated kinase 1	Homo sapiens	0-3
9223178-0	1997	Mean field analysis of FKBP12 complexes with FK506 and rapamycin: implications for a role of crystallographic water molecules in molecular recognition and specificity.	Water	110-115	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	23-29
9223178-2	1997	When crystallographic water molecules are included in the simulations as an extension of the FKBP12 protein surface, there is an appreciable stability gap between the energy of the native FKBP12-FK506 complex and energies of conformations with the "native-like" binding mode.	Water	22-27	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	93-99
9223178-2	1997	When crystallographic water molecules are included in the simulations as an extension of the FKBP12 protein surface, there is an appreciable stability gap between the energy of the native FKBP12-FK506 complex and energies of conformations with the "native-like" binding mode.	Water	22-27	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	188-194
9223178-3	1997	By contrast, the energy spectrum of the FKBP12-rapamycin complex is dense regardless of the presence of the water molecules.	Water	108-113	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	40-46
9223178-4	1997	The stability gap in the FKBP12-FK506 system is determined by two critical water molecules from the effector region that participate in a network of specific hydrogen bond interactions.	Water	75-80	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	25-31
9223188-1	1997	The transitions between the water-equilibrated structures of the GTP and GDP forms of Ha-ras-p21 have been calculated by using the targeted molecular dynamics (TMD) method (Schlitter et al., Mol.	Water	28-33	H3 histone pseudogene 16	Homo sapiens	93-96
9227605-1	1997	Experiments were performed in rats to test the hypothesis that adrenal mRNA levels of tyrosine hydroxylase (TH) and the norepinephrine transporter (NET) would be modified by water deprivation via activation of the sympathetic nervous system.	Water	174-179	solute carrier family 6 member 2	Rattus norvegicus	120-146
9227605-1	1997	Experiments were performed in rats to test the hypothesis that adrenal mRNA levels of tyrosine hydroxylase (TH) and the norepinephrine transporter (NET) would be modified by water deprivation via activation of the sympathetic nervous system.	Water	174-179	solute carrier family 6 member 2	Rattus norvegicus	148-151
9739545-1	1998	The title acid, 3-amino-2-methylpropanoic acid monohydrate, C4H9NO2.H2O, crystallized in the centrosymmetric space group Pbca in the zwitterionic form.	Water	68-71	PBCA	Homo sapiens	121-125
9649340-8	1998	This may indicate that the resting form of ceruloplasmin in plasma under aerobic conditions is a four-electron oxidized form, which is consistent with its function in the four-electron reduction of dioxygen to water.	Water	210-215	ceruloplasmin	Homo sapiens	43-56
9699981-3	1998	The partitioning of the water-insoluble protein fraction, zein (from corn), was affected by the addition of various salts that were soluble in DMFA.	Water	24-29	zein	Zea mays	58-62
24582709-2	2014	The latest designs, including p22 (KKKKP ARVGL GITTV LTMTT QS), are highly soluble in water with minimal aggregation propensity and insert efficiently into cell membranes to form highly conductive ion channels.	Water	86-91	calcineurin like EF-hand protein 1	Homo sapiens	30-33
9841509-2	1998	Here, we show that isolated perfused inner medullary collecting ducts (IMCDs) from vasopressin-escape rats desamino-[D-arginine]vasopressin (DDAVP)/water-loaded have dramatically reduced vasopressin-dependent osmotic water permeabilities [46% of control rats (DDAVP alone)], which coincides with a fall in inner medullary aquaporin-2 protein abundance as measured by immunoblotting in the opposite kidney.	Water	148-153	aquaporin 2	Rattus norvegicus	322-333
9189851-1	1997	Aquaporin-2 (AQP-2) water channel is a key molecule for urinary concentration whose expression is augmented by dehydration in vivo.	Water	20-25	aquaporin 2	Rattus norvegicus	0-11
9189851-1	1997	Aquaporin-2 (AQP-2) water channel is a key molecule for urinary concentration whose expression is augmented by dehydration in vivo.	Water	20-25	aquaporin 2	Rattus norvegicus	13-18
9166788-0	1997	Water and peptide backbone structure in the active center of bovine rhodopsin.	Water	0-5	rhodopsin	Bos taurus	68-77
9841509-6	1998	The decreased cAMP levels can contribute to the demonstrated decrease in collecting duct water permeability in two ways: 1) by causing a decrease in aquaporin-2 expression and 2) by limiting the acute action of vasopressin to increase collecting duct water permeability.	Water	89-94	aquaporin 2	Rattus norvegicus	149-177
9166788-3	1997	Water molecules in rhodopsin that change upon formation of bathorhodopsin are detected by a change in frequency of the O-H stretching vibration from 3538 to 3525 cm(-1).	Water	0-5	rhodopsin	Bos taurus	19-28
25532364-2	2014	According to the conventional standard of oil content in water, simulated the component of oil pollution in I-V water was simulated by preparing samples of CCL4 with oil content.	Water	57-62	C-C motif chemokine ligand 4	Homo sapiens	156-160
9200509-1	1997	Restraint water-immersion stress-induced expression of heat shock protein (HSP)70 mRNA in the cerebral cortex and stomach of rats was evaluated by Northern blotting.	Water	10-15	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	55-81
9612221-9	1998	These studies demonstrate selective expression of AQP1, AQP3, AQP4, and AQP5 in distinct ocular epithelia, predicting specific roles for each in the complex network through which water movements occur in the eye.	Water	179-184	aquaporin 3 (Gill blood group)	Homo sapiens	56-60
9612221-9	1998	These studies demonstrate selective expression of AQP1, AQP3, AQP4, and AQP5 in distinct ocular epithelia, predicting specific roles for each in the complex network through which water movements occur in the eye.	Water	179-184	aquaporin 5	Homo sapiens	72-76
25532364-2	2014	According to the conventional standard of oil content in water, simulated the component of oil pollution in I-V water was simulated by preparing samples of CCL4 with oil content.	Water	112-117	C-C motif chemokine ligand 4	Homo sapiens	156-160
9545259-5	1998	Quantitative measurement of single channel water permeability (pf) using epitope-tagged rat UTs gave pf (in cm3/s x 10(-14)) of 0.14 +/- 0.11 (UT2) and 1.4 +/- 0.2 (UT3), compared with 6.0 and 2.3 for water channels AQP1 and AQP3, respectively.	Water	43-48	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	143-146
25782277-9	2014	Potential values of "new", regenerated, and total production of phytoplankton in the deep-water areas of the Black Sea are identified.	Water	90-95	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	115-118
9100605-4	1997	The time-restricted food and water intakes were associated with variations of gastric pH, plasma gastrin, insulin, glucose, and calcium documented on a circadian basis.	Water	29-34	gastrin	Homo sapiens	97-104
24595738-10	2014	mt2 was able to remove 80 mg L(-1) of Cd after 8 days from original industrial effluent, which was more than Cd removal by mt2 from distilled water (i.e. 77 mg L(-1) after 8 days).	Water	142-147	metallothionein 2A	Homo sapiens	123-126
9122258-5	1997	We examined whether CREB-mediated transcription within the dorsal hippocampus is critical to LTM consolidation of water maze spatial training, which is known to depend on dorsal hippocampal function.	Water	114-119	cAMP responsive element binding protein 1	Rattus norvegicus	20-24
9525951-8	1998	Furthermore, pharmacological studies showed that Colton-null red cells remain sensitive to water and glycerol flux inhibitors, supporting the idea that another proteinaceous path, probably AQP3, mediates most of the glycerol movements across red cell membranes and represents part of the residual water transport activity found in AQP1-deficient red cells.	Water	91-96	aquaporin 3 (Gill blood group)	Homo sapiens	189-193
9525951-8	1998	Furthermore, pharmacological studies showed that Colton-null red cells remain sensitive to water and glycerol flux inhibitors, supporting the idea that another proteinaceous path, probably AQP3, mediates most of the glycerol movements across red cell membranes and represents part of the residual water transport activity found in AQP1-deficient red cells.	Water	297-302	aquaporin 3 (Gill blood group)	Homo sapiens	189-193
22061472-4	1997	RFN samples had lower drip, thaw, cook and total water loss than RSE samples and all water loss traits were lowest for DFD samples and highest for PSE samples.	Water	49-54	RNA exonuclease 2	Homo sapiens	0-3
24894646-5	2014	The trends of characteristic protein expression, including that of nestin, vimentin, GFAP and glutamine synthetase, for astrocytes cultured on super water-repellent fractal PPP surfaces approximate more to in vivo pattern.	Water	149-154	vimentin	Homo sapiens	75-83
9124394-2	1997	We determined whether the abrupt decrease in circulating arginine vasopressin (AVP) by giving excess water affects the expression of AQP-2 mRNA and subcellular localization of AQP-2 in collecting duct cells of the dehydrated rats.	Water	101-106	aquaporin 2	Rattus norvegicus	133-138
9124394-2	1997	We determined whether the abrupt decrease in circulating arginine vasopressin (AVP) by giving excess water affects the expression of AQP-2 mRNA and subcellular localization of AQP-2 in collecting duct cells of the dehydrated rats.	Water	101-106	aquaporin 2	Rattus norvegicus	176-181
24129558-3	2014	The key event for maintenance of body water balance is water reabsorption in the kidney collecting ducts, which is regulated by aquaporin-2 (AQP2).	Water	38-43	aquaporin 2	Homo sapiens	128-139
9124394-3	1997	The 72-h water deprivation increased plasma AVP levels to 3.1 pg/ml and the expression of AQP-2 mRNA by 336% in rats, which were concomitantly abolished by the 40 ml/kg oral water load.	Water	9-14	aquaporin 2	Rattus norvegicus	90-95
9124394-3	1997	The 72-h water deprivation increased plasma AVP levels to 3.1 pg/ml and the expression of AQP-2 mRNA by 336% in rats, which were concomitantly abolished by the 40 ml/kg oral water load.	Water	174-179	aquaporin 2	Rattus norvegicus	90-95
9124394-6	1997	The AQP-2 was diffusely translocated into the cytoplasm 1 h after the forced water administration.	Water	77-82	aquaporin 2	Rattus norvegicus	4-9
9031729-3	1997	Water content and contact angle measurements of SF before and after the modification indicated that the hydrophilicity of the PEG2-SF surface increased compared with that of SF.	Water	0-5	insulin-like growth factor 2	Mus musculus	126-130
8995362-11	1997	The most pronounced decrease of activity was found for the double mutant W393A/W394A which retained only 6% of the activity of the wild-type lipase, while 70% of the activity against water-soluble tributyrylglycerol was retained.	Water	183-188	lipase G, endothelial type	Rattus norvegicus	141-147
9039056-7	1997	In the renal papilla, the Bmax of the homogeneous receptor population (NPR-A) was significantly elevated by long-term EtOH consumption in both strains compared with water-treated controls.	Water	165-170	natriuretic peptide receptor 1	Rattus norvegicus	71-76
9043798-5	1997	All but one (AQP3) are specific water channels and all but one (AQP4) are inactivated by mercurial compounds.	Water	32-37	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
9043798-13	1997	Aquaporin 2, also called WCH-CD, is the water channel of the principal cell of the cortical and medullary collecting duct, and is located in cytoplasmic vesicles unless arginine vasopressin is acting, when it is translocated to the apical membrane by synaptobrevins or vesicle associated membrane protein 2 (VAMP2).	Water	40-45	aquaporin 2	Homo sapiens	0-11
9043798-13	1997	Aquaporin 2, also called WCH-CD, is the water channel of the principal cell of the cortical and medullary collecting duct, and is located in cytoplasmic vesicles unless arginine vasopressin is acting, when it is translocated to the apical membrane by synaptobrevins or vesicle associated membrane protein 2 (VAMP2).	Water	40-45	aquaporin 2	Homo sapiens	25-31
8987746-0	1997	Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain.	Water	33-38	aquaporin 4	Rattus norvegicus	109-120
8987746-3	1997	We used immunocytochemistry and high-resolution immunogold electron microscopy to identify the cells and membrane domains that mediate water flux through AQP4.	Water	135-140	aquaporin 4	Rattus norvegicus	154-158
8987746-8	1997	The highly polarized AQP4 expression indicates that these cells are equipped with specific membrane domains that are specialized for water transport, thereby mediating the flow of water between glial cells and the cavities filled with CSF and the intravascular space.	Water	133-138	aquaporin 4	Rattus norvegicus	21-25
8987746-8	1997	The highly polarized AQP4 expression indicates that these cells are equipped with specific membrane domains that are specialized for water transport, thereby mediating the flow of water between glial cells and the cavities filled with CSF and the intravascular space.	Water	180-185	aquaporin 4	Rattus norvegicus	21-25
8961958-0	1996	Refolding of triosephosphate isomerase in low-water media investigated by fluorescence resonance energy transfer.	Water	46-51	triosephosphate isomerase	Oryctolagus cuniculus	13-38
8943431-5	1996	administration of 5 microg of IL-10 significantly attenuated the increase in regional cerebral blood flow, brain water content, intracranial pressure, and CSF white blood cell count, whereas a lower dosage of IL-10 (0.5 microg) was ineffective.	Water	113-118	interleukin 10	Rattus norvegicus	30-35
8912769-9	1996	In these subjects, twitch Pdi fell from 24.3 +/- 1.6 at baseline to 19.7 +/- 1.6 cm H2O at 10 min postexercise (p &lt; 0.0001, ANOVA).	Water	84-87	peptidyl arginine deiminase 1	Homo sapiens	26-29
8918374-1	1996	Three members of the water channel (aquaporin) family are expressed in adult rat lung: CHIP28 (AQP-1), MIWC (AQP-4), and AQP-5.	Water	21-26	aquaporin 4	Rattus norvegicus	103-107
8918374-1	1996	Three members of the water channel (aquaporin) family are expressed in adult rat lung: CHIP28 (AQP-1), MIWC (AQP-4), and AQP-5.	Water	21-26	aquaporin 4	Rattus norvegicus	109-114
8950488-4	1996	A new water soluble sulfhydryl reactive biotinylation reagent, N-(13-N-maleimdo-4, 7,10-trioxatridecanyl)-biotinamide, was synthesized and used for biotinylation of Fab".	Water	6-11	FA complementation group B	Homo sapiens	165-168
8982850-4	1996	One main protein band corresponding to the molecular weight of MetRS was observed on SDS-PAGE of the final product, which was concentrated by lyophilizing after dialysis against water.	Water	178-183	methionyl-tRNA synthetase 1	Rattus norvegicus	63-68
8810261-0	1996	Selectivity of the renal collecting duct water channel aquaporin-3.	Water	41-46	aquaporin 3 (Gill blood group)	Homo sapiens	55-66
8810261-1	1996	Aquaporin-3 (AQP3) is a water channel found in the basolateral cell membrane of principal cells of the renal collecting tubule as well as in other epithelia.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
8810261-1	1996	Aquaporin-3 (AQP3) is a water channel found in the basolateral cell membrane of principal cells of the renal collecting tubule as well as in other epithelia.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
8900032-2	1996	Pep3-.H2O, where Pep3- = (O-)2P(O)-O-C(CH2)-CO2-, is reported and the systematic structural variations among 19 crystallographic occurrences of H3Pep, H2Pep-, HPep2- and Pep3- species, which are important phosphate donors in the ATP cycle of bioenergetics, are reviewed.	Water	6-9	VPS18 core subunit of CORVET and HOPS complexes	Homo sapiens	0-4
8900032-2	1996	Pep3-.H2O, where Pep3- = (O-)2P(O)-O-C(CH2)-CO2-, is reported and the systematic structural variations among 19 crystallographic occurrences of H3Pep, H2Pep-, HPep2- and Pep3- species, which are important phosphate donors in the ATP cycle of bioenergetics, are reviewed.	Water	6-9	VPS18 core subunit of CORVET and HOPS complexes	Homo sapiens	17-21
8900032-2	1996	Pep3-.H2O, where Pep3- = (O-)2P(O)-O-C(CH2)-CO2-, is reported and the systematic structural variations among 19 crystallographic occurrences of H3Pep, H2Pep-, HPep2- and Pep3- species, which are important phosphate donors in the ATP cycle of bioenergetics, are reviewed.	Water	6-9	VPS18 core subunit of CORVET and HOPS complexes	Homo sapiens	17-21
8887277-2	1996	The mRNAs for HSP-27 and HSP-60 in renal papilla were two- to threefold greater in rats during water restriction than in those excreting a dilute urine, but levels of mRNA for HSP-70 were not reduced by water diuresis and Western analysis for HSP-70 protein showed no difference between water-loaded and water-restricted animals.	Water	95-100	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	25-31
8854772-7	1996	Moreover, the therapeutic effect of water in oil type emulsion encapsulating both OK-432 and IL-2 was greater than that of the solution of BRM in BALB/c mouse with liver metastases of colon 26 tumors.	Water	36-41	interleukin 2	Mus musculus	93-97
8880065-0	1996	A water-soluble, stable dipeptide NK1 receptor-selective neurokinin receptor antagonist with potent in vivo pharmacological effects: S18523.	Water	2-7	substance-P receptor	Cavia porcellus	34-46
8756821-13	1996	Mean magnetic twitch Pdi fell from 39.3 +/- 3.0 during control to 31.1 +/- 3.0 cm H2O at 10 min after loading (p &lt; 0.0001).	Water	82-85	peptidyl arginine deiminase 1	Homo sapiens	21-24
8770174-3	1996	Both 48-h water restriction in Sprague-Dawley rats and 5-day arginine vasopressin (AVP) infusion in Brattleboro rats caused significant increases in the expression levels of two aquaporins, aquaporin-2 and aquaporin-3, while the levels of aquaporin-1 and aquaporin-4 were unchanged.	Water	10-15	aquaporin 2	Rattus norvegicus	190-201
9002792-1	1996	PURPOSE: To identify ultrastructural features resulting from possible primer-water interaction when a two-bottle, acetone- and alcohol-based dentin adhesive (All-Bond 2) was applied to acid-conditioned dentin in the presence of excess water.	Water	77-82	ALL2	Homo sapiens	158-168
9535761-4	1998	However, refolding of yeast cpn10 to a complex that can be recognised by GroEL depends on the presence of a lipid-water interface with a specificity for negatively charged lipids.	Water	114-119	Hsp10p	Saccharomyces cerevisiae S288C	28-33
9566708-6	1998	These results indicate that space restriction and water-immersion stress induced cell proliferation in the glandular stomach through overexpression of proto-oncogenes and increased ODC and SAT activities that might be related to the promotion of gastric carcinogenesis.	Water	50-55	ornithine decarboxylase 1	Rattus norvegicus	181-184
9545428-5	1998	RESULTS: Comb copolymers were synthesized having polycationic backbones (poly-L-lysine, PLL), serving as the anchor for binding to the net negatively charged biological surfaces, grafted with water-soluble polynonionic chains (polyethylene glycol, PEG), to block biological recognition, producing PLL-graft-PEG copolymers.	Water	192-197	progestagen associated endometrial protein	Homo sapiens	248-251
9545428-5	1998	RESULTS: Comb copolymers were synthesized having polycationic backbones (poly-L-lysine, PLL), serving as the anchor for binding to the net negatively charged biological surfaces, grafted with water-soluble polynonionic chains (polyethylene glycol, PEG), to block biological recognition, producing PLL-graft-PEG copolymers.	Water	192-197	progestagen associated endometrial protein	Homo sapiens	307-310
9514097-5	1998	Oral treatment with a selective water-soluble inhibitor of extracellular cathepsin B, Mu-Phe-homoPhe-fluoromethylketone, resulted in 60% reduction of the number of tumors and 80% reduction of the volume of tumors in the three large lobes whereas tumor development was not affected in the small caudate lobe.	Water	32-37	cathepsin B	Rattus norvegicus	73-84
9458821-7	1998	We conclude that the expression of aquaporins in yeast sec6 vesicles is a valid system to further study mammalian water channel function.	Water	114-119	SNARE-binding exocyst subunit SEC6	Saccharomyces cerevisiae S288C	55-59
9451536-9	1998	Excretion of AQP2 decreased significantly after the water load only in the SL subjects.	Water	52-57	aquaporin 2	Homo sapiens	13-17
9451536-11	1998	CONCLUSIONS: Present data demonstrate the following adaptations to HA: decrease in TBW, better ability to handle a water load despite high levels of AVP, a significant decrease in the circulation of vessel dilator, and diminished excretion of AQP2 water channel.	Water	248-253	aquaporin 2	Homo sapiens	243-247
9575420-2	1998	Using magnetic resonance imaging (MRI) and direct measurements of tumor and peritumoral brain water content we found that hCRF treatment (100 micrograms/kg subcutaneously twice a day for 3 days) caused significant inhibition of growth and vascular permeability of the i.c.	Water	94-99	corticotropin releasing hormone	Homo sapiens	122-126
9705607-4	1998	The coincubation with 8-bromo-cAMP (8BrcAMP), a water soluble cAMP analogue, inhibited this GM-CSF stimulation at the protein and the mRNA level.	Water	48-53	colony stimulating factor 2	Homo sapiens	92-98
9880076-4	1998	Amylin"s inhibitory effect on sham feeding appeared behaviorally specific because neither 30 nor 100 microg/kg amylin affected sham drinking of water in thirsty rats and because no abnormal behaviors occurred.	Water	144-149	islet amyloid polypeptide	Rattus norvegicus	0-6
9499589-3	1998	Two-dimensional protein arrays of ferritin and catalase, prepared at air/water interface and transferred onto silicon wafer, could be imaged both in air and in water by AFM using this sharp EBD-tip in contact mode.	Water	73-78	TOR signaling pathway regulator	Homo sapiens	194-197
9499589-3	1998	Two-dimensional protein arrays of ferritin and catalase, prepared at air/water interface and transferred onto silicon wafer, could be imaged both in air and in water by AFM using this sharp EBD-tip in contact mode.	Water	160-165	TOR signaling pathway regulator	Homo sapiens	194-197
9398337-1	1997	Glu-198 of human matrilysin is a conserved residue in the matrix metalloproteinases and is considered to play an important role in catalysis by acting as a general base catalyst toward the zinc-bound water molecule, on the basis of mechanistic proposals for other zinc proteases.	Water	200-205	matrix metallopeptidase 7	Homo sapiens	17-27
9398337-11	1997	Ionization of the zinc-bound water may be responsible for this pKa since the three His ligands and the scaffolding of the matrilysin catalytic zinc site are different from that observed in carboxypeptidase A and would predict a lower pKa for the metal-bound water.	Water	29-34	matrix metallopeptidase 7	Homo sapiens	122-132
9398337-11	1997	Ionization of the zinc-bound water may be responsible for this pKa since the three His ligands and the scaffolding of the matrilysin catalytic zinc site are different from that observed in carboxypeptidase A and would predict a lower pKa for the metal-bound water.	Water	258-263	matrix metallopeptidase 7	Homo sapiens	122-132
9439441-3	1997	The effluent with water was extracted with ethyl acetate two times (pH 1 and 3) and the organic acids were quantitatively converted into their trimethylsilyl derivatives for detection by gas chromatography-mass spectrometry.	Water	18-23	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	68-78
9421967-0	1997	Transmembrane signaling mediated by water in bovine rhodopsin.	Water	36-41	rhodopsin	Bos taurus	52-61
9388476-6	1997	Expression of AQP8 cRNA in Xenopus oocytes increased osmotic water permeability from (0.8 +/- 0.1) x 10(-3) cm/s to (22 +/- 3) x 10(-3) cm/s (10 degrees C) in a mercurial-sensitive manner.	Water	61-66	hypothetical protein LOC734703 S homeolog	Xenopus laevis	14-18
9388476-8	1997	Normalization for oocyte plasma membrane expression using cMyc-tagged AQP8 indicated a single channel water permeability of 8.2 x 10(-14) cm3/s.	Water	102-107	aquaporin 8	Mus musculus	70-74
9388476-9	1997	AQP8 is unique among the water channels in terms of its urea permeability and its strong expression in gastrointestinal organs, placenta and heart.	Water	25-30	aquaporin 8	Mus musculus	0-4
9409467-0	1997	Perinatal changes in expression of aquaporin-4 and other water and ion transporters in rat lung.	Water	57-62	aquaporin 4	Rattus norvegicus	35-46
9409467-21	1997	The transient perinatal induction of AQP4, which could be prenatally induced by beta-adrenergic agonists, and the localization of this water channel strongly suggest that it plays a critical role for removal of lung liquid at the time of birth.	Water	135-140	aquaporin 4	Rattus norvegicus	37-41
9395318-0	1997	A molecular dynamics study in explicit water of the reduced and oxidized forms of yeast iso-1-cytochrome c--solvation and dynamic properties of the two oxidation states.	Water	39-44	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	88-93
9299519-2	1997	It is believed that among the five known mammalian aquaporins, kidney aquaporin (AQP2) is the only water channel that is regulated by arginine vasopressin (AVP).	Water	99-104	aquaporin 2	Homo sapiens	81-85
9299519-4	1997	The application of AVP to Xenopus oocytes injected with AQP1 cRNA increased the membrane permeability to water.	Water	105-110	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	56-60
9299520-6	1997	It is proposed that amino acid 113 functions as part of a clamp that lines the mouth of the water channel leading to the active sites of the hGSTP1-1 dimer and controls the access to substrates.	Water	92-97	glutathione S-transferase pi 1	Homo sapiens	141-147
9321919-2	1997	Incubation with HgCl2 inhibited the osmotic water permeability (Pf) of human (h) AQP2 by 40%, whereas inhibition of hAQP1 was 75%.	Water	44-49	aquaporin 2	Homo sapiens	81-85
9321919-7	1997	In conclusion, water transport through AQP2 is less sensitive to mercury inhibition than through AQP1.	Water	15-20	aquaporin 2	Homo sapiens	39-43
8760244-1	1996	Aquaporin-2 (AQP-2) is the arginine vasopressin-regulated water channel of the renal collecting ducts.	Water	58-63	aquaporin 2	Rattus norvegicus	0-11
8760244-1	1996	Aquaporin-2 (AQP-2) is the arginine vasopressin-regulated water channel of the renal collecting ducts.	Water	58-63	aquaporin 2	Rattus norvegicus	13-18
8760258-1	1996	Aquaporin-1 (AQP1), located in proximal tubules (PT) and descending thin limbs of Henle (DTL), and aquaporin-2 (AQP2), located in collecting ducts (CD), are channels involved in water transport across renal tubule epithelia.	Water	178-183	aquaporin 2	Homo sapiens	99-110
8841040-6	1996	ETSa appeared a useful assay for the study of evolutive history of the water masses in the Mediterranean Sea.	Water	71-76	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	105-108
24129558-3	2014	The key event for maintenance of body water balance is water reabsorption in the kidney collecting ducts, which is regulated by aquaporin-2 (AQP2).	Water	38-43	aquaporin 2	Homo sapiens	141-145
8642417-0	1996	Endogenous substance P mediates cold water stress-induced increase in interleukin-6 secretion from peritoneal macrophages.	Water	37-42	tachykinin 1	Mus musculus	11-22
8642417-3	1996	The stress paradigm involved subjecting male C57BL/6J mice to 5 min swim tests in 10 +/- 2 degrees C water twice daily for 4 d. Cold water stress augments the lipopolysaccharide-induced IL-6 secretion from peritoneal macrophages, elevates immunoreactive SP (iSP) in the peritoneal wash fluid, and reduces iSP in certain peritoneum-containing tissues or organs (i.e., diaphragm, abdominal wall, ileum, and rectum).	Water	133-138	tachykinin 1	Mus musculus	254-256
9245401-4	1997	In hGSTP1-1, the cavity is approximately half hydrophobic and half hydrophilic and is defined by the side chains of Y7, F8, V10, R13, V104, Y108, N204, and G205 and five water molecules.	Water	170-175	glutathione S-transferase pi 1	Homo sapiens	3-11
8642417-7	1996	These results suggest that cold water stress promotes the release of SP from peritoneal tissues into the peritoneal cavity, where it participates in the cold water stress-induced macrophage functional alterations.	Water	32-37	tachykinin 1	Mus musculus	69-71
24129558-3	2014	The key event for maintenance of body water balance is water reabsorption in the kidney collecting ducts, which is regulated by aquaporin-2 (AQP2).	Water	55-60	aquaporin 2	Homo sapiens	128-139
24129558-3	2014	The key event for maintenance of body water balance is water reabsorption in the kidney collecting ducts, which is regulated by aquaporin-2 (AQP2).	Water	55-60	aquaporin 2	Homo sapiens	141-145
24129558-4	2014	AQP2 is a channel that is exclusively selective for water molecules and never allows permeation of ions or other small molecules.	Water	52-57	aquaporin 2	Homo sapiens	0-4
9468600-1	1997	We have characterized the selectivity filter of the water channel aquaporin-1 (AQP1) of proximal straight tubules (PST), as an equivalent cylindrical structure with a diameter of approximately 4.5 A, where water molecules single file.	Water	52-57	aquaporin-1	Oryctolagus cuniculus	66-77
24129558-6	2014	However, when the body is dehydrated and needs to retain water, AQP2 relocates to the apical membrane, allowing water reabsorption from the urinary tubule into the cell.	Water	57-62	aquaporin 2	Homo sapiens	64-68
9468600-1	1997	We have characterized the selectivity filter of the water channel aquaporin-1 (AQP1) of proximal straight tubules (PST), as an equivalent cylindrical structure with a diameter of approximately 4.5 A, where water molecules single file.	Water	52-57	aquaporin-1	Oryctolagus cuniculus	79-83
9468600-1	1997	We have characterized the selectivity filter of the water channel aquaporin-1 (AQP1) of proximal straight tubules (PST), as an equivalent cylindrical structure with a diameter of approximately 4.5 A, where water molecules single file.	Water	206-211	aquaporin-1	Oryctolagus cuniculus	66-77
8735223-10	1996	The CA1 grafted group was also as successful as controls in matching-to-position in the water maze and substantially superior to the other ischaemic groups, assessed using three trials/day, with a 30-s inter-trial interval and a different platform position on each day.	Water	88-93	carbonic anhydrase 1	Rattus norvegicus	4-7
9468600-1	1997	We have characterized the selectivity filter of the water channel aquaporin-1 (AQP1) of proximal straight tubules (PST), as an equivalent cylindrical structure with a diameter of approximately 4.5 A, where water molecules single file.	Water	206-211	aquaporin-1	Oryctolagus cuniculus	79-83
24129558-6	2014	However, when the body is dehydrated and needs to retain water, AQP2 relocates to the apical membrane, allowing water reabsorption from the urinary tubule into the cell.	Water	112-117	aquaporin 2	Homo sapiens	64-68
24752989-3	2014	We find that amyloid precursor protein (APP) mice require considerably more training than controls to reach the same level of performance in a water maze task, and recall the trained location less well 24 h later.	Water	143-148	amyloid beta (A4) precursor protein	Mus musculus	13-38
9261869-5	1997	The functional implications of Tyr7 in the activation of the glutathione thiol group are discussed in the light of present results, which in agreement with previous studies suggest that Tyr7 in un-ionized form contributes to the catalytic process of glutathione S-transferase, the thiolate anion being stabilized by hydrogen bond with Tyr7 and by interactions with hydrating water molecules.	Water	375-380	glutathione S-transferase kappa 1	Homo sapiens	250-275
8645729-2	1996	The contributions of amino-acid side-chain groups to the amide I bands of rhGM-CSF in H2O and in D2O solutions were carefully scrutinized, as 40% of the total 127 amino-acid residues of rhGM-CSF is side-chain absorptive (asparagine, glutamine, etc.).	Water	86-89	colony stimulating factor 2	Homo sapiens	79-82
8645729-4	1996	Reduction of rhGM-CSF with dithiothreitol caused apparent unfolding of the native conformation followed by the time-dependent increase of beta-aggregation bands which arose at 1622 and 1693 cm(-1) in H2O, 1613 and 1684 cm(-1) in D2O solutions.	Water	200-203	colony stimulating factor 2	Homo sapiens	18-21
8782866-6	1996	AS1, AS2, AS3 and AS4 each significantly reduced body weight (7-17 g), food intake (8-13 g) and water intake (11-23 ml), while the vehicle or MS1 conditions significantly increased weight (9-20 g) and produced smaller reductions (2-4 g) in food intake.	Water	96-101	PDS5 cohesin associated factor B	Rattus norvegicus	10-13
23736674-2	2014	The discovery of underlying genes identified key molecules involved in urinary concentration, including the type 2 vasopressin receptor AVPR2 and the water channel AQP2, which constitute obvious pharmacologic targets.	Water	150-155	aquaporin 2	Homo sapiens	164-168
9172765-0	1996	Nuclear magnetic resonance study of the conformation and dynamics of beta-casein at the oil/water interface in emulsions.	Water	92-97	casein beta	Homo sapiens	69-80
9172765-1	1996	A (13)C and (31)P nuclear magnetic resonance (NMR) study has been carried out on beta-casein adsorbed at the interface of a tetradecane/water emulsion.	Water	136-141	casein beta	Homo sapiens	81-92
24968001-4	2014	Transfer from water to an apolar solvent such as CCl4 is unlikely to occur, but our results suggest that if forced, the DNA would migrate surrounded by a small shell of water (the higher the DNA charge, the larger the number of water molecules in this shell).	Water	14-19	C-C motif chemokine ligand 4	Homo sapiens	49-53
8928802-6	1996	Uroguanylin joins guanylin as an intestinal peptide that may participate in an intrinsic pathway for cGMP-mediated regulation of intestinal salt and water transport.	Water	149-154	guanylate cyclase activator 2A	Homo sapiens	3-11
11669984-1	1997	sigma-Bond metathesis reactions of water and methanol with palladium hydride and methyl complexes to yield hydrogen and methane, respectively, have been studied using ab-initio molecular orbital methods at the second-order Moller-Plesset (MP2) perturbation level.	Water	35-40	tryptase pseudogene 1	Homo sapiens	239-242
9246049-8	1997	The synthesis of HSP60 was specifically induced by water-immersion stress in the pancreas.	Water	51-56	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	17-22
9246049-9	1997	Cerulein-induced pancreatitis was clearly prevented by specific preinduction of HSP60 by water-immersion stress.	Water	89-94	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	80-85
24968001-4	2014	Transfer from water to an apolar solvent such as CCl4 is unlikely to occur, but our results suggest that if forced, the DNA would migrate surrounded by a small shell of water (the higher the DNA charge, the larger the number of water molecules in this shell).	Water	169-174	C-C motif chemokine ligand 4	Homo sapiens	49-53
24968001-4	2014	Transfer from water to an apolar solvent such as CCl4 is unlikely to occur, but our results suggest that if forced, the DNA would migrate surrounded by a small shell of water (the higher the DNA charge, the larger the number of water molecules in this shell).	Water	169-174	C-C motif chemokine ligand 4	Homo sapiens	49-53
9195910-0	1997	Water and glycerol permeabilities of aquaporins 1-5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes.	Water	0-5	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	37-51
8967344-8	1996	Forty-eight hours after release of BUO, the reduction in AQP-2 expression persisted (19 +/- 8%, P &lt; 0.001), concurrent with a marked nonosmotic postobstructive polyuria, as determined by a significant reduction in free-water clearance (-50 +/- 7 vs. -85 +/- 10 microliters.min-1.kg-1, P &lt; 0.05).	Water	222-227	aquaporin 2	Rattus norvegicus	57-62
24938410-3	2014	Here, we report the first example of a SERS-based sensor for chemical speciation of toxic metal ions in water at trace levels.	Water	104-109	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	39-43
8632430-1	1996	The conformation of the sodium salt of mycophenolic acid (MPA), a potent inhibitor of inosine monophosphate dehydrogenase (IMPD), derived from 1D DIFNOE and 2D ROESY experiments in water and molecular dynamics (MD) is described.	Water	181-186	inosine monophosphate dehydrogenase 1	Homo sapiens	86-121
8632430-1	1996	The conformation of the sodium salt of mycophenolic acid (MPA), a potent inhibitor of inosine monophosphate dehydrogenase (IMPD), derived from 1D DIFNOE and 2D ROESY experiments in water and molecular dynamics (MD) is described.	Water	181-186	inosine monophosphate dehydrogenase 1	Homo sapiens	123-127
9261989-7	1997	These findings confirm our previous value of dp = 4.5 A for the diameter of the selectivity filter of the basolateral PST cell membrane water channel AQP1.	Water	136-141	aquaporin-1	Oryctolagus cuniculus	150-154
9227644-2	1997	Furthermore, the vasopressin-induced increase in apical membrane water permeability of renal principal cells is dependent on a rise in intracellular adenosine 3",5"-cyclic monophosphate and activation of protein kinase A (PKA).	Water	65-70	protein kinase cAMP-activated catalytic subunit alpha	Sus scrofa	204-220
24751343-6	2014	The water contact angle (WCA) test also noted the differences of these two fibers: PCL/PEG core/sheath fibers with cross-linked PEG surface exhibited more hydrophilic property.	Water	4-9	progestagen associated endometrial protein	Homo sapiens	87-90
9227644-2	1997	Furthermore, the vasopressin-induced increase in apical membrane water permeability of renal principal cells is dependent on a rise in intracellular adenosine 3",5"-cyclic monophosphate and activation of protein kinase A (PKA).	Water	65-70	protein kinase cAMP-activated catalytic subunit alpha	Sus scrofa	222-225
8704105-1	1996	The vasopressin-sensitive water channel (aquaporin 2; AQP-2) mediates water transport across the apical plasma membrane of the renal collecting ducts and is excreted in human urine.	Water	26-31	aquaporin 2	Homo sapiens	54-59
24635833-2	2014	Vasopressin-1a receptors (V1aR) and aquaporin-4 (AQP4) regulate water transport and brain edema formation, perhaps in part by modulating cation fluxes.	Water	64-69	aquaporin 4	Rattus norvegicus	36-47
8704105-5	1996	AQP-2 urinary excretion changed with short-term alterations in hydration status produced either by water loading (76% decrease, P &lt; 0.01) or by 3% sodium chloride (760% increase, P &lt; 0.01).	Water	99-104	aquaporin 2	Homo sapiens	0-5
9198101-14	1997	The opening pressure of lumbar CSF was 180 mm H2O and the CSF contained 39 cells/microliter, 79 mg of protein, and 10 mg/dl of glucose.	Water	46-49	colony stimulating factor 2	Homo sapiens	31-34
24635833-2	2014	Vasopressin-1a receptors (V1aR) and aquaporin-4 (AQP4) regulate water transport and brain edema formation, perhaps in part by modulating cation fluxes.	Water	64-69	aquaporin 4	Rattus norvegicus	49-53
8617713-1	1996	The mercurial insensitive water channel (MIWC, AQP-4) is a water-selective transporter expressed at the basolateral plasma membrane of principal cells in kidney collecting duct, airway epithelium, and gastric parietal cells, as well as in astrocytes and skeletal muscle plasmalemma.	Water	26-31	aquaporin 4	Rattus norvegicus	41-45
9144258-0	1997	Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct.	Water	102-107	aquaporin 2	Rattus norvegicus	90-101
9144258-6	1997	In contrast, immunoblotting demonstrated a lack of an increase in expression of AQP1 and AQP3 water channel expression, indicating that the effect on AQP2 was selective.	Water	94-99	aquaporin 3 (Gill blood group)	Rattus norvegicus	89-93
8685170-13	1996	Some rare cases, transmission of which is autosomal recessive, result from homozygous mutations of aquaporin 2 gene, a water channel involved in the water reabsorption in the renal collecting duct.	Water	119-124	aquaporin 2	Homo sapiens	99-110
25013459-1	2014	Sequential polymerization of N-carboxyanhydrides accelerated by nitrogen flow is utilized to generate a novel well-defined diblock copolypeptide (PDI = 1.08), with incorporation of alkyne-functionalized side-chain groups allowing for rapid and efficient thiol-yne click-type modifications, followed by self-assembly into nanopure water to construct a helical polypeptide-based versatile and functional nanoparticle platform.	Water	330-335	peptidyl arginine deiminase 1	Homo sapiens	146-153
8685170-13	1996	Some rare cases, transmission of which is autosomal recessive, result from homozygous mutations of aquaporin 2 gene, a water channel involved in the water reabsorption in the renal collecting duct.	Water	149-154	aquaporin 2	Homo sapiens	99-110
24884609-5	2014	First, we confirmed that the four ITIH4 N-X-S/T sequons (N81, N207, N517, and N577) were glycosylated by treating ITIH4 tryptic/GluC glycopeptides with PNGaseF in the presence of (18)O water.	Water	185-190	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	34-39
8547275-0	1996	Heme oxygenase (HO-1): His-132 stabilizes a distal water ligand and assists catalysis.	Water	51-56	heme oxygenase 1	Homo sapiens	16-20
9289995-2	1997	Estimations indicate that the end-respiration pulmonary positive pressure inevitably develops during HF FVL; its value is 30 cm H2O and it starts no later than 10 sec after the beginning of HF FVL.	Water	128-131	coagulation factor V	Homo sapiens	104-107
24884609-5	2014	First, we confirmed that the four ITIH4 N-X-S/T sequons (N81, N207, N517, and N577) were glycosylated by treating ITIH4 tryptic/GluC glycopeptides with PNGaseF in the presence of (18)O water.	Water	185-190	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	114-119
8561506-1	1996	We have been able to demonstrate that cytochrome b4 interacts closely with cytochrome P450 in the microsomal membrane, and that substrates can serve to order the interaction: Using the water-soluble carbodiimide EDC we could crosslink cytochrome b5 and CYP2B4 in microsomes from phenobarbital-treated rabbits and cytochrome b5 and CYP1A2 in microsomes from beta-naphthoflavone-treated animals.	Water	185-190	cytochrome P450 2B4	Oryctolagus cuniculus	253-259
24631653-2	2014	Peroxiredoxin2 (PRX2) is one of six mammalian isoenzymes (PRX1-6) that can reduce hydrogen peroxide (H2O2) and organic hydroperoxides to water and alcohols.	Water	137-142	peroxiredoxin 1	Homo sapiens	58-64
8561506-1	1996	We have been able to demonstrate that cytochrome b4 interacts closely with cytochrome P450 in the microsomal membrane, and that substrates can serve to order the interaction: Using the water-soluble carbodiimide EDC we could crosslink cytochrome b5 and CYP2B4 in microsomes from phenobarbital-treated rabbits and cytochrome b5 and CYP1A2 in microsomes from beta-naphthoflavone-treated animals.	Water	185-190	cytochrome P450 1A2	Oryctolagus cuniculus	331-337
8555200-8	1996	The stabilization of the protonated side chain of Asp26 in human thioredoxin is achieved via a hydrogen-bonding network involving the hydroxyl group of the neighboring Ser28 which is then connected to the active site region (comprising Cys32 and Cys35) via bound water molecules.	Water	263-268	thioredoxin	Homo sapiens	65-76
9135666-2	1997	METHOD: The T2 of the water and lipid fractions of bone marrow was selectively measured in the L1-3 vertebral bodies using the chemical shift misregistration effect on MRI.	Water	22-27	immunoglobulin kappa variable 2-4 (pseudogene)	Homo sapiens	95-99
25342939-3	2014	The present review discusses possible mechanisms, focusing on the role of NKCC1, an astrocytic cotransporter of Na(+), K(+), 2Cl(-) and water and its activation by highly increased extracellular K(+) concentrations in the development of cytotoxic cell swelling.	Water	136-141	solute carrier family 12 member 2	Homo sapiens	74-79
9119993-0	1997	Upregulation of aquaporin-2 water channel expression in chronic heart failure rat.	Water	28-33	aquaporin 2	Rattus norvegicus	16-27
9119993-1	1997	Aquaporin-2 (AQP2) mediates vasopressin-regulated collecting duct water permeability.	Water	66-71	aquaporin 2	Rattus norvegicus	0-11
9119993-1	1997	Aquaporin-2 (AQP2) mediates vasopressin-regulated collecting duct water permeability.	Water	66-71	aquaporin 2	Rattus norvegicus	13-17
9119993-3	1997	We hypothetized that upregulation of aquaporin-2 water channel could account for the water retention in CHF.	Water	49-54	aquaporin 2	Rattus norvegicus	37-48
9119993-3	1997	We hypothetized that upregulation of aquaporin-2 water channel could account for the water retention in CHF.	Water	85-90	aquaporin 2	Rattus norvegicus	37-48
8869740-1	1996	PI-specific PLC enzymes are a key component of phosphatidylinositol-mediated signaling pathways since the hydrophobic product, diacylglycerol, activates protein kinase C and the water-soluble product, inositol trisphosphate, is involved in Ca2+ mobilization.	Water	178-183	heparan sulfate proteoglycan 2	Homo sapiens	12-15
8869740-3	1996	A series of inhibitors, both lipophilic and water-soluble, have been synthesized to target each of these two classes of PLC enzymes.	Water	44-49	heparan sulfate proteoglycan 2	Homo sapiens	120-123
9119993-12	1997	The results indicate a major role for vasopressin in the upregulation of AQP2 water channels and water retention in experimental CHF in the rat.	Water	78-83	aquaporin 2	Rattus norvegicus	73-77
25342939-4	2014	However, it also mentions that due to a 3/2 ratio between Na(+) release and K(+) uptake by the Na(+),K(+)-ATPase driving NKCC1 brain extracellular fluid can become hypertonic, which may facilitate water entry across the blood-brain barrier, essential for development of edema.	Water	197-202	solute carrier family 12 member 2	Homo sapiens	121-126
25342939-6	2014	V1 antagonists are likely to protect against cytotoxic edema formation by inhibiting AVP enhancement of NKCC1-mediated uptake of ions and water, whereas beta1-adrenergic antagonists prevent edema formation because beta1-adrenergic stimulation alone is responsible for stimulation of the Na(+),K(+)-ATPase driving NKCC1, first and foremost due to decrease in extracellular Ca(2+) concentration.	Water	138-143	solute carrier family 12 member 2	Homo sapiens	104-109
24956959-12	2014	We propose that AQP1, 3, and 5 may constitute a transepithelial water pathway via glandular secretions and across the surface epithelium, which provides a possible means for rapid and controllable water movement in the nasal respiratory mucosa of a panting species.	Water	64-69	aquaporin-1	Ovis aries	16-20
9049170-9	1997	These results indicate that targeting of Aquaporin-1 to the apical and basolateral plasma membrane is independent of cell type and show for the first time that water flow through a cultured epithelium can be blocked by mercurial compounds.	Water	160-165	aquaporin-1	Canis lupus familiaris	41-52
8772465-5	1996	In a manner identical to that reported for the mammalian ADH-elicited water channel AQP2, AQP-TB expression is increased significantly by intervals of dehydration or chronic ADH stimulation.	Water	70-75	aquaporin 2	Homo sapiens	84-88
24956959-12	2014	We propose that AQP1, 3, and 5 may constitute a transepithelial water pathway via glandular secretions and across the surface epithelium, which provides a possible means for rapid and controllable water movement in the nasal respiratory mucosa of a panting species.	Water	197-202	aquaporin-1	Ovis aries	16-20
8625365-9	1996	When MeArg therapy was given orally (1 mg/ml drinking water), a substantial drop in NO production, as well as reduction in capillary leakage was noted in IL-2-treated healthy mice.	Water	54-59	interleukin 2	Mus musculus	154-158
9133620-1	1997	Mouse epidermal growth factor (EGF) was covalently conjugated with the water-soluble polymer, poly(acrylic acid) (EGF-PAA), or with the water-insoluble polymer, surface-hydrolyzed poly(methyl methacrylate) (EGF-PMMA).	Water	71-76	epidermal growth factor	Mus musculus	31-34
9133620-1	1997	Mouse epidermal growth factor (EGF) was covalently conjugated with the water-soluble polymer, poly(acrylic acid) (EGF-PAA), or with the water-insoluble polymer, surface-hydrolyzed poly(methyl methacrylate) (EGF-PMMA).	Water	136-141	epidermal growth factor	Mus musculus	31-34
9243020-0	1996	Water on early Mars.	Water	0-5	methionyl-tRNA synthetase 1	Homo sapiens	15-19
24522493-2	2014	Loss of V2R function prevents plasma membrane expression of the AQP2 water channel in the kidney collecting duct cells and impairs the kidney concentration ability.	Water	69-74	aquaporin 2	Mus musculus	64-68
9243020-1	1996	Large flood channels, valley networks and a variety of features attributed to the action of ground ice indicate that Mars emerged from heavy bombardment 3.8 Ga ago, with an inventory of water at the surface equivalent to at least a few hundred metres spread over the whole planet, as compared with 3 km for the Earth.	Water	186-191	methionyl-tRNA synthetase 1	Homo sapiens	117-121
9243020-2	1996	The mantle of Mars is much drier than that of the Earth, possibly as a result of global melting at the end of accretion and the lack of plate tectonics to subsequently reintroduce water into the interior.	Water	180-185	methionyl-tRNA synthetase 1	Homo sapiens	14-18
24945437-6	2014	Functionally, compared to littermates, Ednrb-/- mice showed increased transepithelial resistance, reduced stool water content and similar chloride secretion in the distal colon.	Water	112-117	endothelin receptor type B	Mus musculus	39-44
8565513-14	1996	By day 8, lung compliance also increased from baseline significantly more in TLC C-53 patients than in placebo patients (5.7 +/- 1.7 vs -1.5 +/- 1.8 mL/cm H2O; p = .01).	Water	155-158	CDK5 regulatory subunit associated protein 3	Homo sapiens	81-85
8641135-1	1996	The chromosome location of the gene encoding aquaporin 3 (AQP3), which functions as a channel for water and small polar solutes in the basolateral membrane of the collecting duct of the kidney, was determined.	Water	98-103	aquaporin 3 (Gill blood group)	Homo sapiens	45-56
9048572-7	1997	It was concluded that addition and elimination reactions involving the 5.6-bond of pyrimidine substrates do not require general acid/base catalysis or, alternatively, the water molecules in the TS active site serve this role.	Water	171-176	thymidylate synthetase	Homo sapiens	194-196
9070263-3	1997	Therefore, we investigated whether mdr2 P-glycoprotein is involved in the transport of a water-soluble short chain phosphatidylcholine analogue L-alpha-dibutyroyl-PC (diC4PC) induced by expression of liver mRNA in Xenopus laevis oocytes.	Water	89-94	ATP binding cassette subfamily B member 4	Rattus norvegicus	35-39
8641135-1	1996	The chromosome location of the gene encoding aquaporin 3 (AQP3), which functions as a channel for water and small polar solutes in the basolateral membrane of the collecting duct of the kidney, was determined.	Water	98-103	aquaporin 3 (Gill blood group)	Homo sapiens	58-62
24503139-14	2014	SRB were detected by BART tests in the test water main.	Water	44-49	ADP ribosylation factor like GTPase 2 binding protein	Homo sapiens	21-25
9136639-1	1996	Water oxygen-17 and deuteron spin relaxation rates, measured as a function of resonance frequency, have been used to study the dynamics of protein hydration in aqueous solutions of ribonuclease A, lysozyme, myoglobin, trypsin and serum albumin.	Water	0-5	myoglobin	Homo sapiens	207-216
9033386-5	1997	Lys211 of the K3 mutant, which corresponds to Lys111 of E-selectin, interacts with each of the three bound ligands: the N zeta atom donates a hydrogen bond to the 4-OH of Gal in 3"-NeuAc-Le(x), forms a water-mediated hydrogen bond with the 4-OH of Gal in 3"-sulfo-Le(x), and forms a salt bridge with the sulfate group of 4"-sulfo-Le(x).	Water	202-207	selectin E	Homo sapiens	56-66
23800944-1	2014	BACKGROUND: Aquaporin-3 (AQP3) is a water transporting protein which plays an oncogenic role in several malignant tumors.	Water	36-41	aquaporin 3 (Gill blood group)	Homo sapiens	12-23
9124401-0	1997	Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts.	Water	68-73	aquaporin 3 (Gill blood group)	Rattus norvegicus	48-52
9124401-1	1997	Aquaporin-3 (AQP3) is unique in its structure (lowest homology with other aquaporins) and in its function (significantly conductive to both small nonelectrolytes and water).	Water	166-171	aquaporin 3 (Gill blood group)	Rattus norvegicus	0-11
9124401-1	1997	Aquaporin-3 (AQP3) is unique in its structure (lowest homology with other aquaporins) and in its function (significantly conductive to both small nonelectrolytes and water).	Water	166-171	aquaporin 3 (Gill blood group)	Rattus norvegicus	13-17
9124401-10	1997	The human AQP3 stimulated osmotic water permeability by eightfold, which was inhibited by 0.3 mM mercury chloride by 34% and reversed by beta-mercaptoethanol.	Water	34-39	aquaporin 3 (Gill blood group)	Homo sapiens	10-14
9124401-11	1997	Our results indicate that AQP3 is a glycosylated protein and a mercury-sensitive water channel localized at the basolateral membrane of principal cells and IMCD cells, and its expression is induced by dehydration at both protein and mRNA level.	Water	81-86	aquaporin 3 (Gill blood group)	Rattus norvegicus	26-30
9039043-4	1997	One of these water channels, aquaporin-2, has been shown to be the target for short-term regulation of collecting duct water permeability by vasopressin.	Water	13-18	aquaporin 2	Homo sapiens	29-40
9039043-4	1997	One of these water channels, aquaporin-2, has been shown to be the target for short-term regulation of collecting duct water permeability by vasopressin.	Water	119-124	aquaporin 2	Homo sapiens	29-40
8951616-5	1996	This mechanism is unclear, but one possibility is that Gly-Pro from substrate might bind amino acids or dipeptides instead of water molecules as DPPIV transpeptidyl activity reported previously.	Water	126-131	dipeptidyl peptidase 4	Homo sapiens	145-150
8987045-2	1996	First identified in red blood cells, AQP1 was shown to function as a water channel when expressed in Xenopus oocytes or when pure AQP1 protein was reconstituted into synthetic membranes.	Water	69-74	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	37-41
8987045-6	1996	AQP2 is expressed only in the principal cells of renal collecting duct where it is the predominant vasopressin (ADH, antidiuretic hormone) regulated water channel.	Water	149-154	aquaporin 2	Homo sapiens	0-4
8987045-9	1996	AQP3 resides in the basolateral membranes of renal collecting duct principal cells providing an exit pathway for water; AQP4 is abundant in brain where it may function as the hypothalamic osmoreceptor responsible for secretion of ADH.	Water	113-118	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
9039043-5	1997	In addition, two collecting duct water channels, aquaporin-2 and aquaporin-3, are targets for long-term regulation by vasopressin through effects on the absolute expression levels of the water channel proteins.	Water	33-38	aquaporin 2	Homo sapiens	49-60
9039043-5	1997	In addition, two collecting duct water channels, aquaporin-2 and aquaporin-3, are targets for long-term regulation by vasopressin through effects on the absolute expression levels of the water channel proteins.	Water	33-38	aquaporin 3 (Gill blood group)	Homo sapiens	65-76
9039044-7	1997	We conclude that amylin acts on renal proximal tubules to promote sodium and water reabsorption and cell proliferation.	Water	77-82	islet amyloid polypeptide	Rattus norvegicus	17-23
23800944-1	2014	BACKGROUND: Aquaporin-3 (AQP3) is a water transporting protein which plays an oncogenic role in several malignant tumors.	Water	36-41	aquaporin 3 (Gill blood group)	Homo sapiens	25-29
8624289-5	1995	More water-soluble and non-nephrotoxic analogues were developed with an interesting diversity in biochemical profile, particularly with respect to interactions with the reduced-folate cell membrane carrier (RFC) and folylpolyglutamate synthetase (FPGS).	Water	5-10	folylpolyglutamate synthase	Homo sapiens	216-245
24418925-1	2014	Aquaporin 3 (AQP3) is located in the basal layer of the epidermis and regulates biological functions of skin such as water content and trans-epidermal water loss.	Water	117-122	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
8624289-5	1995	More water-soluble and non-nephrotoxic analogues were developed with an interesting diversity in biochemical profile, particularly with respect to interactions with the reduced-folate cell membrane carrier (RFC) and folylpolyglutamate synthetase (FPGS).	Water	5-10	folylpolyglutamate synthase	Homo sapiens	247-251
8605711-2	1995	Since peritoneal interstitium is one of the main resistance sites of peritoneal transport, the level of PAI-1 in the peritoneum may have a significant effect on water and solute transport during peritoneal dialysis (PD) via its effect of peritoneal ECM.	Water	161-166	serpin family E member 1	Homo sapiens	104-109
8994636-3	1997	Comparison with the results obtained from relaxation time measurements of the purified enzymes in vitro and from theoretical calculations showed that two of the labeled enzymes, phosphoglycerate kinase and hexokinase, were tumbling in a cytoplasm that had a viscosity approximately twice that of water.	Water	296-301	hexokinase	Saccharomyces cerevisiae S288C	206-216
24418925-1	2014	Aquaporin 3 (AQP3) is located in the basal layer of the epidermis and regulates biological functions of skin such as water content and trans-epidermal water loss.	Water	117-122	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
24418925-1	2014	Aquaporin 3 (AQP3) is located in the basal layer of the epidermis and regulates biological functions of skin such as water content and trans-epidermal water loss.	Water	151-156	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
24418925-1	2014	Aquaporin 3 (AQP3) is located in the basal layer of the epidermis and regulates biological functions of skin such as water content and trans-epidermal water loss.	Water	151-156	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
9059546-15	1997	Study 6: Water for injection caused marked up-regulation of CD1 1b and down-regulation of L-selectin.	Water	9-14	selectin L	Homo sapiens	90-100
7560075-2	1995	Body water balance is controlled by vasopressin, which regulates Aquaporin-2 (AQP2) water channels in kidney collecting duct cells by vesicular trafficking between intracellular vesicles and the plasma membrane.	Water	5-10	aquaporin 2	Homo sapiens	65-76
7560075-2	1995	Body water balance is controlled by vasopressin, which regulates Aquaporin-2 (AQP2) water channels in kidney collecting duct cells by vesicular trafficking between intracellular vesicles and the plasma membrane.	Water	5-10	aquaporin 2	Homo sapiens	78-82
24590923-11	2014	Water deprivation increased plasma sodium and diuresis but decreased AQP-2 (46 +- 22 vs 112 +- 25;  p &lt; 0.05) and eNOS expression in the kidney.	Water	0-5	aquaporin 2	Rattus norvegicus	69-74
7560075-14	1995	In conclusion, VAMP2, a component of the neuronal SNARE complex, is expressed in vesicles carrying AQP2, suggesting a role in vasopressin-regulated vesicle trafficking of AQP2 water channels.	Water	176-181	aquaporin 2	Homo sapiens	171-175
7573395-1	1995	Aquaporin-2 (AQP2) is the predominant vasopressin-regulated water channel of the renal collecting duct.	Water	60-65	aquaporin 2	Rattus norvegicus	0-11
9339210-5	1997	Lead in tap water ranged from 0.2 to 230 (mean 15) micrograms/L and exceeded in 39% of the samples the maximum level recommended by WHO, 10 micrograms/L.	Water	12-17	filamin B	Homo sapiens	8-11
7573395-1	1995	Aquaporin-2 (AQP2) is the predominant vasopressin-regulated water channel of the renal collecting duct.	Water	60-65	aquaporin 2	Rattus norvegicus	13-17
32261679-3	2014	The result of its water proton relaxation rate indicates that its positive relaxivity per Gd3+ ion or per nanozeolite particle is relatively high, due to the efficient immobilization and enrichment of Gd3+ ions in the micropores as well as the large surface-to-volume ratio of nanozeolite.	Water	18-23	GRDX	Homo sapiens	90-93
7573395-6	1995	This increase averaged 2.0-fold in untreated rats and 2.9-fold in rats water loaded for 12 h. Water loading, presumably by suppressing circulating vasopressin levels, decreased the fraction of AQP2 associated with the plasma membrane by 55%, suggesting retrieval of AQP2 from the plasma membrane.	Water	71-76	aquaporin 2	Rattus norvegicus	193-197
7573395-6	1995	This increase averaged 2.0-fold in untreated rats and 2.9-fold in rats water loaded for 12 h. Water loading, presumably by suppressing circulating vasopressin levels, decreased the fraction of AQP2 associated with the plasma membrane by 55%, suggesting retrieval of AQP2 from the plasma membrane.	Water	94-99	aquaporin 2	Rattus norvegicus	193-197
7573395-6	1995	This increase averaged 2.0-fold in untreated rats and 2.9-fold in rats water loaded for 12 h. Water loading, presumably by suppressing circulating vasopressin levels, decreased the fraction of AQP2 associated with the plasma membrane by 55%, suggesting retrieval of AQP2 from the plasma membrane.	Water	94-99	aquaporin 2	Rattus norvegicus	266-270
7573395-8	1995	The accentuation of the DDAVP response seen after water loading is consistent with the observed increase in the fraction of AQP2 in the intracellular pool available for insertion.	Water	50-55	aquaporin 2	Rattus norvegicus	124-128
9378100-2	1997	The shift of vibrational peak frequencies with the temperature of myoglobin in sucrose/water and glycerol/water solutions is used to probe the expansion of the hydrogen bond network.	Water	87-92	myoglobin	Homo sapiens	66-75
32261679-3	2014	The result of its water proton relaxation rate indicates that its positive relaxivity per Gd3+ ion or per nanozeolite particle is relatively high, due to the efficient immobilization and enrichment of Gd3+ ions in the micropores as well as the large surface-to-volume ratio of nanozeolite.	Water	18-23	GRDX	Homo sapiens	201-204
9226477-2	1997	interleukin-10 (25, 50, and 100 ng/rat) effects on water intake, exploratory behaviour, and rectal temperature were evaluated in rats treated intraperitoneally (i.p.)	Water	51-56	interleukin 10	Rattus norvegicus	0-14
24904528-4	2014	Current findings support this hypothesis as SCT-SCTR axis participates in modulating social interaction, spatial learning, water and food intake, motor coordination, and motor learning behaviors.	Water	123-128	secretin receptor	Homo sapiens	48-52
9230467-5	1997	According to the data collected in this study, CCK might possibly use this pathway, whereas accumulation of gastrin on the cell membrane with prefolding of the ligand at the water/lipid interface is hardly conceivable.	Water	174-179	gastrin	Homo sapiens	108-115
7675222-6	1995	RESULTS: CSF pressures decreased in all eight patients, from a mean of 353 +/- 35 to a mean of 168 +/- 12 mm H2O (p &lt; 0.001), following mean weight loss of 57 +/- 5 kg (p &lt; 0.001) when measured at 34 +/- 8 months after surgery.	Water	109-112	colony stimulating factor 2	Homo sapiens	9-12
7646471-0	1995	Thrombin-thrombomodulin interaction: energetics and potential role of water as an allosteric effector.	Water	70-75	thrombomodulin	Homo sapiens	9-23
24655828-1	2014	Despite the strong adsorption of hydroxide ions, the surface tension of water is almost independent of pH between pH 1 and 13 when the pH is adjusted by addition of HCl or NaOH.	Water	72-77	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	114-125
7629169-4	1995	Productive chelation to an active site metal ion by the N terminus of substrates is indicated, with a water molecule ligated to that hyper(Lewis)acidic center prior to substrate binding supplying the pKa of 6.6.	Water	102-107	protein kinase cAMP-activated catalytic subunit alpha	Sus scrofa	200-203
8995537-3	1997	Here we report that nociceptin is physiologically active in vivo and produces marked changes in the renal excretion of water and sodium.	Water	119-124	prepronociceptin	Rattus norvegicus	20-30
24995117-10	2014	Administration of UTI significantly decreased the infarct volume, water content of the brain tissue and neurological scores.	Water	66-71	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	18-21
8995537-7	1997	The magnitude and pattern of the central nociceptin-induced water diuresis was similar to that produced by i.c.v.	Water	60-65	prepronociceptin	Rattus norvegicus	41-51
8995537-11	1997	Thus, these results indicate that in conscious rats, nociceptin produces a selective water diuresis via a central nervous system mechanism independent of kappa-opioid receptors.	Water	85-90	prepronociceptin	Rattus norvegicus	53-63
7475989-0	1995	Cucumber cotyledon lipoxygenase oxygenizes trilinolein at the lipid/water interface.	Water	68-73	LOW QUALITY PROTEIN: linoleate 9S-lipoxygenase 6	Cucumis sativus	19-31
7475989-5	1995	This suggests that cucumber cotyledon lipoxygenase acts only on an insoluble substrate at the lipid/water interface but not on a soluble one.	Water	100-105	LOW QUALITY PROTEIN: linoleate 9S-lipoxygenase 6	Cucumis sativus	38-50
24754754-2	2014	The water-mediated neutral hydrolysis mechanism of carbonyl sulfide (OCS) has been re-examined using the hybrid supramolecule/continuum models with n = 2-8 explicit water cluster at the level of MP2(fc)(CPCM)/6-311++G(d,p)//MP2(fc)(CPCM)/6-31+G(d).	Water	4-9	tryptase pseudogene 1	Homo sapiens	195-198
7630138-11	1995	Both IGF-I and GLN independently decreased BT to MLN (P &lt; 0.05) and, in combination, enhanced water absorption (P &lt; 0.05).	Water	97-102	insulin-like growth factor 1	Rattus norvegicus	5-10
12223602-0	1997	Water Deficit Rapidly Stimulates the Activity of a Protein Kinase in the Elongation Zone of the Maize Primary Root.	Water	0-5	protein kinase	Zea mays	51-65
24754754-2	2014	The water-mediated neutral hydrolysis mechanism of carbonyl sulfide (OCS) has been re-examined using the hybrid supramolecule/continuum models with n = 2-8 explicit water cluster at the level of MP2(fc)(CPCM)/6-311++G(d,p)//MP2(fc)(CPCM)/6-31+G(d).	Water	4-9	tryptase pseudogene 1	Homo sapiens	224-227
8977100-1	1996	Uroguanylin, a member of the guanylin peptide family, is a novel peptide regulator for intestinal salt and water transport.	Water	107-112	guanylate cyclase activator 2B	Rattus norvegicus	0-11
24738840-4	2014	More importantly, we demonstrate that the fabricated NRC aerogels can also collect micrometer-sized oil droplets from an oil-water mixture with high efficiency that is well beyond what can be achieved by most existing separation methods, but is extremely important in practical marine oil-spill recovery because a certain amount of oils often shears into many micrometer-sized oil droplets by the sea wave, resulting in enormous potential destruction to marine ecosystem if not properly collected.	Water	125-130	nuclear receptor coactivator 6	Homo sapiens	53-56
8977100-7	1996	Evidence for uroguanylin expression in extra-gastrointestinal tissues indicates the possible existence of a novel system for water and electrolyte homeostasis, and a more global effect of uroguanylin on epithelial cell function.	Water	125-130	guanylate cyclase activator 2B	Rattus norvegicus	13-24
8997366-8	1996	IAPP also decreased body weight gain and water intake dose dependently.	Water	41-46	islet amyloid polypeptide	Rattus norvegicus	0-4
7578502-2	1995	Since peritoneal ECM is a resistance site for peritoneal transport, the production and release of PAI-1 in the peritoneum may affect the peritoneal transport of water and small solutes.	Water	161-166	serpin family E member 1	Homo sapiens	98-103
24738963-2	2014	Here, we report that a largely hydrated, conserved, buried aspartic acid in the water cavity modulates the dynamics of the interacting loops of yeast thioredoxin 1 (yTrx1).	Water	80-85	thioredoxin TRX1	Saccharomyces cerevisiae S288C	165-170
7480361-3	1995	The results indicated that these water extracts contained the principles acting on the dopamine (D1 &amp; D2), muscarinice acetylcholine (M1), or 5-HT (5-HT1A &amp; 5-HT2) receptors, or the benzodiazepine and the gamma-amino-n-butyric acid (GABA) binding sites of GABAA receptors as determined by receptor binding assays.	Water	33-38	5-hydroxytryptamine receptor 1A	Homo sapiens	152-158
7480361-4	1995	The receptors or binding sites which predominantly acted by each water extract are listed as follows: Chaihu: D2, 5-HT1A, GABA; Chuanxiong: GABA, 5-HT1A; Danggui: GABA, 5-HT1A; Danshen: BDZ; Duhuo: GABA, 5-HT1A, D2, D1; Hangqin: BDZ, D1, 5-HT1A; Qinjiao: GABA, BDZ, 5-HT1A, D2; Shengma: 5-HT1A; Suanzaoren: 5-HT1A, 5-HT2, GABA; Yangjihua: M1, 5-HT1A, 5-HT2.	Water	65-70	5-hydroxytryptamine receptor 1A	Homo sapiens	114-120
7480361-4	1995	The receptors or binding sites which predominantly acted by each water extract are listed as follows: Chaihu: D2, 5-HT1A, GABA; Chuanxiong: GABA, 5-HT1A; Danggui: GABA, 5-HT1A; Danshen: BDZ; Duhuo: GABA, 5-HT1A, D2, D1; Hangqin: BDZ, D1, 5-HT1A; Qinjiao: GABA, BDZ, 5-HT1A, D2; Shengma: 5-HT1A; Suanzaoren: 5-HT1A, 5-HT2, GABA; Yangjihua: M1, 5-HT1A, 5-HT2.	Water	65-70	5-hydroxytryptamine receptor 1A	Homo sapiens	146-152
7480361-4	1995	The receptors or binding sites which predominantly acted by each water extract are listed as follows: Chaihu: D2, 5-HT1A, GABA; Chuanxiong: GABA, 5-HT1A; Danggui: GABA, 5-HT1A; Danshen: BDZ; Duhuo: GABA, 5-HT1A, D2, D1; Hangqin: BDZ, D1, 5-HT1A; Qinjiao: GABA, BDZ, 5-HT1A, D2; Shengma: 5-HT1A; Suanzaoren: 5-HT1A, 5-HT2, GABA; Yangjihua: M1, 5-HT1A, 5-HT2.	Water	65-70	5-hydroxytryptamine receptor 1A	Homo sapiens	146-152
8921953-2	1996	Here we report that a selected adjuvant comprising block copolymers in a water-in-oil emulsion can induce balanced TH1/TH2 responses in BALB/c mice primed at 1 week of age with an immunodominant tetanus peptide vaccine.	Water	73-78	heart and neural crest derivatives expressed 2	Mus musculus	119-122
7480361-4	1995	The receptors or binding sites which predominantly acted by each water extract are listed as follows: Chaihu: D2, 5-HT1A, GABA; Chuanxiong: GABA, 5-HT1A; Danggui: GABA, 5-HT1A; Danshen: BDZ; Duhuo: GABA, 5-HT1A, D2, D1; Hangqin: BDZ, D1, 5-HT1A; Qinjiao: GABA, BDZ, 5-HT1A, D2; Shengma: 5-HT1A; Suanzaoren: 5-HT1A, 5-HT2, GABA; Yangjihua: M1, 5-HT1A, 5-HT2.	Water	65-70	5-hydroxytryptamine receptor 1A	Homo sapiens	146-152
24738963-7	2014	By measuring the hydration and molecular dynamics simulation of wild-type yTrx1 and the D24N mutant, we showed that Asn24 is more exposed to water than Asp24 and the water cavity is smaller in the mutant, closing the inner part of the water cavity.	Water	141-146	thioredoxin TRX1	Saccharomyces cerevisiae S288C	74-79
7480361-4	1995	The receptors or binding sites which predominantly acted by each water extract are listed as follows: Chaihu: D2, 5-HT1A, GABA; Chuanxiong: GABA, 5-HT1A; Danggui: GABA, 5-HT1A; Danshen: BDZ; Duhuo: GABA, 5-HT1A, D2, D1; Hangqin: BDZ, D1, 5-HT1A; Qinjiao: GABA, BDZ, 5-HT1A, D2; Shengma: 5-HT1A; Suanzaoren: 5-HT1A, 5-HT2, GABA; Yangjihua: M1, 5-HT1A, 5-HT2.	Water	65-70	5-hydroxytryptamine receptor 1A	Homo sapiens	146-152
7480361-4	1995	The receptors or binding sites which predominantly acted by each water extract are listed as follows: Chaihu: D2, 5-HT1A, GABA; Chuanxiong: GABA, 5-HT1A; Danggui: GABA, 5-HT1A; Danshen: BDZ; Duhuo: GABA, 5-HT1A, D2, D1; Hangqin: BDZ, D1, 5-HT1A; Qinjiao: GABA, BDZ, 5-HT1A, D2; Shengma: 5-HT1A; Suanzaoren: 5-HT1A, 5-HT2, GABA; Yangjihua: M1, 5-HT1A, 5-HT2.	Water	65-70	5-hydroxytryptamine receptor 1A	Homo sapiens	146-152
7480361-4	1995	The receptors or binding sites which predominantly acted by each water extract are listed as follows: Chaihu: D2, 5-HT1A, GABA; Chuanxiong: GABA, 5-HT1A; Danggui: GABA, 5-HT1A; Danshen: BDZ; Duhuo: GABA, 5-HT1A, D2, D1; Hangqin: BDZ, D1, 5-HT1A; Qinjiao: GABA, BDZ, 5-HT1A, D2; Shengma: 5-HT1A; Suanzaoren: 5-HT1A, 5-HT2, GABA; Yangjihua: M1, 5-HT1A, 5-HT2.	Water	65-70	5-hydroxytryptamine receptor 1A	Homo sapiens	146-152
7480361-4	1995	The receptors or binding sites which predominantly acted by each water extract are listed as follows: Chaihu: D2, 5-HT1A, GABA; Chuanxiong: GABA, 5-HT1A; Danggui: GABA, 5-HT1A; Danshen: BDZ; Duhuo: GABA, 5-HT1A, D2, D1; Hangqin: BDZ, D1, 5-HT1A; Qinjiao: GABA, BDZ, 5-HT1A, D2; Shengma: 5-HT1A; Suanzaoren: 5-HT1A, 5-HT2, GABA; Yangjihua: M1, 5-HT1A, 5-HT2.	Water	65-70	5-hydroxytryptamine receptor 1A	Homo sapiens	146-152
24738963-7	2014	By measuring the hydration and molecular dynamics simulation of wild-type yTrx1 and the D24N mutant, we showed that Asn24 is more exposed to water than Asp24 and the water cavity is smaller in the mutant, closing the inner part of the water cavity.	Water	166-171	thioredoxin TRX1	Saccharomyces cerevisiae S288C	74-79
24738963-7	2014	By measuring the hydration and molecular dynamics simulation of wild-type yTrx1 and the D24N mutant, we showed that Asn24 is more exposed to water than Asp24 and the water cavity is smaller in the mutant, closing the inner part of the water cavity.	Water	166-171	thioredoxin TRX1	Saccharomyces cerevisiae S288C	74-79
24810045-10	2014	Addition of the drug to food or drinking water lowered levels of phospho-Ser129 alpha-synuclein in the brain of treated animals.	Water	41-46	synuclein alpha	Homo sapiens	80-95
7794277-3	1995	It is therefore very likely that the interaction with myosin (that requires the expulsion of the protein solvation water) is more problematic for phalloidin-F-actin that for native F-actin.	Water	115-120	myosin heavy chain 14	Homo sapiens	54-60
7640759-5	1995	Other types of inheritance have been described in NDI, and recently, a mutation of the aquaporin-2 gene, encoding a water channel of the renal collecting duct, has been reported in an autosomal recessive form of NDI.	Water	116-121	aquaporin 2	Homo sapiens	87-98
11540240-7	1995	This disequilibrium is probably due to sea level-induced changes in shallow water calcium carbonate deposition/dissolution, an interpretation that does not conflict with pelagic sedimentary data from the central Pacific.	Water	76-81	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	39-42
7540151-1	1995	According to the "shuttle hypothesis", vasopressin increases the water permeability of renal epithelial cells by exocytotic fusion of vesicles containing the water channel AQP-CD with the apical plasma membrane, whereas withdrawal of vasopressin results in endocytotic uptake of AQP-CD.	Water	65-70	aquaporin 2	Rattus norvegicus	172-178
7540151-1	1995	According to the "shuttle hypothesis", vasopressin increases the water permeability of renal epithelial cells by exocytotic fusion of vesicles containing the water channel AQP-CD with the apical plasma membrane, whereas withdrawal of vasopressin results in endocytotic uptake of AQP-CD.	Water	158-163	aquaporin 2	Rattus norvegicus	172-178
7538665-1	1995	Two water channel homologs were cloned recently from rat kidney, mercurial-insensitive water channel (MIWC) and glycerol intrinsic protein (GLIP).	Water	4-9	aquaporin 4	Rattus norvegicus	65-100
7538665-1	1995	Two water channel homologs were cloned recently from rat kidney, mercurial-insensitive water channel (MIWC) and glycerol intrinsic protein (GLIP).	Water	4-9	aquaporin 4	Rattus norvegicus	102-106
7538665-9	1995	These studies suggest water/solute transporting roles for MIWC and GLIP in the urinary concentrating mechanism, cerebrospinal fluid absorption, ocular fluid balance, fecal dehydration, and airway humidification.	Water	22-27	aquaporin 4	Rattus norvegicus	58-62
7756350-0	1995	Phospholipase A2 domain formation in hydrolyzed asymmetric phospholipid monolayers at the air/water interface.	Water	94-99	LOC104974671	Bos taurus	0-16
7756350-1	1995	Phospholipase A2 (PLA2) catalyzed hydrolysis of asymmetric 1-caproyl-2-palmitoyl-phosphatidylcholine (6,16-PC) and 1-palmitoyl-2-caproyl-phosphatidylcholine (16,6-PC) lipid monolayers at the air/water interface was investigated.	Water	195-200	LOC104974671	Bos taurus	0-16
7756350-1	1995	Phospholipase A2 (PLA2) catalyzed hydrolysis of asymmetric 1-caproyl-2-palmitoyl-phosphatidylcholine (6,16-PC) and 1-palmitoyl-2-caproyl-phosphatidylcholine (16,6-PC) lipid monolayers at the air/water interface was investigated.	Water	195-200	LOC104974671	Bos taurus	18-22
7542539-8	1995	The AQP-CD localization is consistent with the predicted site of the antidiuretic hormone (ADH)-regulated water channel in the collecting ducts and the increase in AQP-CD at mRNA and protein levels by dehydration may account for high concentration of urine in dehydrated subjects.	Water	106-111	aquaporin 2	Rattus norvegicus	4-10
7538073-3	1995	A combination of homonuclear Hartmann Hahn two-dimensional experiment and roating-frame Overhauser enhancement spectroscopy of the Fab/peptide complex measured in H2O was used to eliminate the resonances of the Fab and the tightly bound peptide residues and to obtain sequential assignments for those parts of the peptide which retain considerable mobility upon binding.	Water	163-166	FA complementation group B	Homo sapiens	131-134
7707377-0	1995	Contributions of tryptophan 24 and glutamate 30 to binding long-lived water molecules in the ternary complex of human dihydrofolate reductase with methotrexate and NADPH studied by site-directed mutagenesis and nuclear magnetic resonance spectroscopy.	Water	70-75	dihydrofolate reductase	Homo sapiens	118-141
7707377-1	1995	Previous NMR studies on the ternary complex of human dihydrofolate reductase (hDHFR) with methotrexate (MTX) and NADPH detected six long-lived bound water molecules.	Water	149-154	dihydrofolate reductase	Homo sapiens	53-76
7707377-1	1995	Previous NMR studies on the ternary complex of human dihydrofolate reductase (hDHFR) with methotrexate (MTX) and NADPH detected six long-lived bound water molecules.	Water	149-154	dihydrofolate reductase	Homo sapiens	78-83
7708669-5	1995	Comparison with the crystal structures of H-2Kb in complex with peptides VSV-8 (RGYVYQGL) and SEV-9 (FAPGNYPAL), where a Tyr residue is used as the C pocket anchor, reveals that the conserved water molecule that binds into the B pocket and mediates hydrogen bonding from the buried anchor hydroxyl group could not be likewise positioned if the P2 side chain were of significant size.	Water	192-197	histocompatibility 2, K1, K region	Mus musculus	42-47
7796158-5	1995	Restraint-water immersion stress significantly increased the level of cerebral HSC70 mRNAs for 6 h and 12 h. Stress for 6 h with recovery for 6 h induced more gastric HSC70 mRNA levels than that without recovery, while stress for 12 h expressed the highest gastric HSC70 mRNA levels.	Water	10-15	heat shock protein family A (Hsp70) member 8	Rattus norvegicus	79-84
7796158-5	1995	Restraint-water immersion stress significantly increased the level of cerebral HSC70 mRNAs for 6 h and 12 h. Stress for 6 h with recovery for 6 h induced more gastric HSC70 mRNA levels than that without recovery, while stress for 12 h expressed the highest gastric HSC70 mRNA levels.	Water	10-15	heat shock protein family A (Hsp70) member 8	Rattus norvegicus	167-172
7796158-5	1995	Restraint-water immersion stress significantly increased the level of cerebral HSC70 mRNAs for 6 h and 12 h. Stress for 6 h with recovery for 6 h induced more gastric HSC70 mRNA levels than that without recovery, while stress for 12 h expressed the highest gastric HSC70 mRNA levels.	Water	10-15	heat shock protein family A (Hsp70) member 8	Rattus norvegicus	167-172
7539369-5	1995	The binary mixture of 2 micrograms/liter, 3,4-dichloroaniline and 40 micrograms/liter lindane in tap water had an influence on growth on the early life stages of zebrafish.	Water	101-106	transporter associated with antigen processing, subunit type c	Danio rerio	97-100
7878682-10	1995	Lead-related increases in GSTs were partially reversed by transferring animals previously receiving lead to lead-free water for a 4-week period.	Water	118-123	glutathione S-transferase alpha 4	Rattus norvegicus	26-30
7539496-0	1995	The AQP2 water channel: effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats.	Water	9-14	aquaporin 2	Rattus norvegicus	4-8
7539496-1	1995	Aquaporin 2 is a collecting duct water channel that is located in apical vesicles and in the apical plasma membrane of collecting duct principal cells.	Water	33-38	aquaporin 2	Rattus norvegicus	0-11
7539496-7	1995	This behavior is consistent with the idea that AQP2 is the vasopressin-sensitive water channel.	Water	81-86	aquaporin 2	Rattus norvegicus	47-51
8590218-6	1995	Other water channels (aquaporin 2) are involved in the fine tuning of the final osmolarity of urine in mammalian kidney or amphibian urinary bladder.	Water	6-11	aquaporin 2	Homo sapiens	22-33
8590218-11	1995	Finally some kidney water channels (aquaporin 3) are localized in the basolateral plasma membrane of the same cells, where they contribute to the high transepithelial water permeability.	Water	20-25	aquaporin 3 (Gill blood group)	Homo sapiens	36-47
8590218-13	1995	Unlike previous members of the family, aquaporin 5, that was cloned most recently, is involved in the water secretion that occurs in lacrimal and salivary glands.	Water	102-107	aquaporin 5	Homo sapiens	39-50
7758538-1	1995	The enzyme catalase protects aerobic organisms from oxygen free radical damage by converting hydrogen peroxide to molecular oxygen and water before it can decompose to form the highly reactive hydroxyl radical.	Water	135-140	Catalase	Drosophila melanogaster	11-19
7873048-4	1995	The fish were immersed into 1 of 2 doses (10 and 100 micrograms/100 ml water) of insulin or no hormone for 15 min per week for 8 weeks.	Water	71-76	insulin	Bos taurus	81-88
7811289-6	1994	The RIA we established is a promising tool for clarifying the physiological functions and pathophysiological significance of guanylin in water and electrolyte homeostasis.	Water	137-142	guanylate cyclase activator 2A	Homo sapiens	125-133
9007566-2	1996	On scanning electron microscopy, a corrosion cast of alveolar capillaries in lungs treated with beta APN appeared abnormal in configuration; transmission electron microscopy showed extensive morphological changes in interstitial cells and ECMs, including collagen, elastin, and presumably glycosaminoglycans and, in binding water (GBW).	Water	324-329	alanyl aminopeptidase, membrane	Rattus norvegicus	101-104
8810926-5	1996	By analysis of high-frequency EPR spectra, we determine the number of water molecules in the first coordination sphere of the manganous ion to be four in p21.Mn(II).GDP, consistent with prior low-frequency EPR and X-ray crystallographic studies.	Water	70-75	H3 histone pseudogene 16	Homo sapiens	154-157
8964076-3	1996	We have demonstrated previously that recombinant Escherichia coli expressing retinal S-antigen induces EAU in Lewis rats.	Water	103-106	S-antigen visual arrestin	Rattus norvegicus	77-94
8964076-5	1996	We examined the effect of oral administration of E. coli expressing retinal S-antigen on the development of EAU induced with native S-antigen in Lewis rats.	Water	108-111	S-antigen visual arrestin	Rattus norvegicus	68-85
8964076-5	1996	We examined the effect of oral administration of E. coli expressing retinal S-antigen on the development of EAU induced with native S-antigen in Lewis rats.	Water	108-111	S-antigen visual arrestin	Rattus norvegicus	76-85
8781445-5	1996	In addition, electron paramagnetic resonance spectroscopy of H2O-Cbl preparations showed the presence of a small amount of Cob-(II)alamin that was capable of combining with NO.	Water	61-64	Cbl proto-oncogene	Homo sapiens	65-68
8781445-5	1996	In addition, electron paramagnetic resonance spectroscopy of H2O-Cbl preparations showed the presence of a small amount of Cob-(II)alamin that was capable of combining with NO.	Water	61-64	metabolism of cobalamin associated B	Homo sapiens	123-126
9389074-1	1996	A continuous flow analysis system for the preconcentration of Cu2+ and/or Cd2+ in water was developed.	Water	82-87	CD2 molecule	Homo sapiens	74-77
8880911-5	1996	Enhanced low-temperature stability of apoA-2 observed upon increase in Na2HPO4 concentration from 0.3 mM to 50 mM or addition of 10% glycerol may be linked to reduced water activity.	Water	167-172	apolipoprotein A2	Homo sapiens	38-44
15048380-1	1996	Suppressed ion chromatography has been applied to the determination of S(IV) species in cloud and fog water in the range 0.012-2.4 mg S(IV)-S/L.	Water	102-107	IV	Homo sapiens	71-76
8812490-7	1996	Expression of hKID cRNA in Xenopus oocytes did not increase glycerol or urea permeability, but increased osmotic water permeability from (2.8 +/- 0.5) x 10(-4) to (7.4 +/- 0.7) x 10(-4) cm/s (10 degrees C) in a mercurial-sensitive manner.	Water	113-118	aquaporin 6	Homo sapiens	14-18
8713101-1	1996	Guanylin (GCAP-I, guanylate cyclase activating peptide I) and uroguanylin (GCAP-II, guanylate cyclase activating peptide II) are regulatory peptides involved in the regulation of the intestinal chloride / water balance.	Water	205-210	guanylate cyclase activator 2A	Homo sapiens	0-8
8663387-7	1996	The three-dimensional structures of beta3 and beta1 are virtually identical, with the exception that Cys-369 and two water molecules in beta3 occupy the position of Arg-369 in beta1.	Water	117-122	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	36-51
8663387-7	1996	The three-dimensional structures of beta3 and beta1 are virtually identical, with the exception that Cys-369 and two water molecules in beta3 occupy the position of Arg-369 in beta1.	Water	117-122	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	36-41
8680701-6	1996	For the group, transcutaneous twitch Pdi was significantly decreased from 27.0 +/- 1.9 at baseline to 21.4 +/- 1.7 cm H2O (p &lt; 0.0001) at 10 min posthyperpnea.	Water	118-121	peptidyl arginine deiminase 1	Homo sapiens	37-40
8680701-7	1996	Magnetic twitch Pdi was also significantly decreased from 36.0 +/- 2.1 at baseline to 28.7 +/- 1.9 cm H2O (p &lt; 0.0001) at 10 min posthyperpnea.	Water	102-105	peptidyl arginine deiminase 1	Homo sapiens	16-19
8712693-3	1996	Administration of drinking water containing 0.03% verapamil or dexverapamil resulted in a decrease in the incidence and size of gamma-glutamyl transpeptidase-positive foci.	Water	27-32	gamma-glutamyltransferase 1	Rattus norvegicus	128-157
8706705-8	1996	These results indicate that Zn2+ directly interacts with CD38 to stimulate its ADP-ribosyl cyclase with inhibition of its NAD+ glycohydrolase, probably due to prevention of the access of water molecule to an intermediate of the enzymesubstrate complex.	Water	187-192	CD38 molecule	Homo sapiens	57-61
8756970-4	1996	In addition, the use of mud packs and Dead Sea salts dissolved in regular bath water outside the Dead Sea region are also effective, although to a lesser degree than when applied at the Dead Sea area itself.	Water	79-84	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	43-46
8756970-4	1996	In addition, the use of mud packs and Dead Sea salts dissolved in regular bath water outside the Dead Sea region are also effective, although to a lesser degree than when applied at the Dead Sea area itself.	Water	79-84	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	102-105
8756970-4	1996	In addition, the use of mud packs and Dead Sea salts dissolved in regular bath water outside the Dead Sea region are also effective, although to a lesser degree than when applied at the Dead Sea area itself.	Water	79-84	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	102-105
8675687-3	1996	In this paper, we demonstrate that the arcades are a site of expression of two proteins, aquaporin-2 (the vasopressin-regulated water channel) and the V2 vasopressin receptor, that are important to regulated water transport in the kidney.	Water	128-133	aquaporin 2	Rattus norvegicus	89-100
8675687-3	1996	In this paper, we demonstrate that the arcades are a site of expression of two proteins, aquaporin-2 (the vasopressin-regulated water channel) and the V2 vasopressin receptor, that are important to regulated water transport in the kidney.	Water	208-213	aquaporin 2	Rattus norvegicus	89-100
8675692-11	1996	Together, the results suggest that the decrease in AVP-stimulated osmotic water permeability results, at least in part, in the decrease in AQP2 protein.	Water	74-79	aquaporin 2	Rattus norvegicus	139-143
8909784-15	1996	Water follows, producing prolonged postsynaptic swelling in the CA1 and dentate regions where AMPA receptors are most abundant.	Water	0-5	carbonic anhydrase 1	Rattus norvegicus	64-67
8933206-10	1996	Stimulation with a sonicated B. burgdorferi preparation in the presence of the water-soluble compound Prednisolone-21-hemisuccinate considerably reduced expression of ICAM-1, and marginally also of E-selectin, whereas the level of P-selectin and VCAM-1 remained unaltered.	Water	79-84	vascular cell adhesion molecule 1	Mus musculus	246-252
8621489-8	1996	Expression of human AQP5 in Xenopus oocytes conferred mercurial-sensitive osmotic water permeability (Pf) equivalent to other aquaporins.	Water	82-87	aquaporin 5	Homo sapiens	20-24
8967344-0	1996	Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney.	Water	87-92	aquaporin 2	Rattus norvegicus	81-86
8967344-2	1996	In this study, we examined the effect of BUO and release of BUO on the expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2) in rat kidney.	Water	111-116	aquaporin 2	Rattus norvegicus	138-143
16856315-4	1994	The specific activity (micromol x min(-1) x g protein(-1)) of lactase in ajejunal mucosal homogenate and a purified membrane fraction was lower in pigs fed colostrum than in unfed newborns or those fed either milk or water.	Water	217-222	LOW QUALITY PROTEIN: lactase-phlorizin hydrolase	Sus scrofa	62-69
7879533-0	1994	[The Vibrio flora of the bodies of water in the recreational areas along the Black Sea shore and its role in human pathology].	Water	35-40	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	83-86
7879705-6	1994	Both oral and topical ocular treatment with LEF suppressed the ocular disease signs and symptoms and retinal necrosis and reduced the S-Ag antibody levels associated with EAU in a dose-dependent manner.	Water	171-174	S-antigen visual arrestin	Rattus norvegicus	134-138
7524315-0	1994	Patients with autosomal nephrogenic diabetes insipidus homozygous for mutations in the aquaporin 2 water-channel gene.	Water	99-104	aquaporin 2	Homo sapiens	87-98
24760830-2	2014	We report a 1.45-A resolution structure of yeast iso-1-cytochrome c with the Met80 heme ligand swung out of the heme crevice and replaced by a water molecule.	Water	143-148	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	49-54
7524358-0	1994	Functional characterization and cell immunolocalization of AQP-CD water channel in kidney collecting duct.	Water	66-71	aquaporin 2	Rattus norvegicus	59-65
24509911-0	2014	Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1.	Water	14-19	anoctamin 1	Homo sapiens	76-83
7524358-6	1994	Osmotic water permeability (Pf) of oocytes expressing AQP-CD was 138 +/- 19 microns/s (mean +/- SE), 12 times greater than the control (11 +/- 3 microns/s), 90% inhibited by 0.3 mM HgCl2, and weakly temperature dependent (energy of activation for Pf was 4.0 kcal/mol).	Water	8-13	aquaporin 2	Rattus norvegicus	54-60
7524358-11	1994	Our results indicated that AQP-CD is a 29-kDa protein, a selective water channel, distinct from a urea channel, and localized to the membranes of vasopressin-sensitive components in kidney collecting duct principal cells.	Water	67-72	aquaporin 2	Rattus norvegicus	27-33
24509911-0	2014	Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1.	Water	14-19	anoctamin 1	Homo sapiens	84-95
24509911-9	2014	Thus, physical and functional interactions between TRPV4 and ANO1 can modulate water transport in the choroid plexus.	Water	79-84	anoctamin 1	Homo sapiens	61-65
24189739-2	1994	Copolymerized of acrylated derivatives ofalpha-chymotrypsin and polyethylene glycol (PEG) have been prepared and used as biocatalysts for the synthesis of model peptides in organic solvents containing a very low quantity of water.	Water	224-229	progestagen associated endometrial protein	Homo sapiens	64-89
24492996-2	2014	Brain lesions are frequently observed in regions enriched in expression of the aquaporin-4 (AQP4) water channel, an antigenic target of the NMO IgG serologic marker.	Water	98-103	aquaporin 4	Rattus norvegicus	79-90
24492996-2	2014	Brain lesions are frequently observed in regions enriched in expression of the aquaporin-4 (AQP4) water channel, an antigenic target of the NMO IgG serologic marker.	Water	98-103	aquaporin 4	Rattus norvegicus	92-96
7884677-4	1994	The slopes of plots of log PRX vs log KRX were 0.85, 0.91, 0.99, and 2.4, respectively, for hexadecane/water, hexadecene/water, 1,9-decadiene/water, and octanol/water with the best model solvent being that which yielded a slope closest to unity.	Water	103-108	periaxin	Homo sapiens	27-30
7884677-4	1994	The slopes of plots of log PRX vs log KRX were 0.85, 0.91, 0.99, and 2.4, respectively, for hexadecane/water, hexadecene/water, 1,9-decadiene/water, and octanol/water with the best model solvent being that which yielded a slope closest to unity.	Water	121-126	periaxin	Homo sapiens	27-30
24684587-4	2014	The morphology of the MEH-PPV thin film at the air/water interface can be controlled by the spreading solvent.	Water	51-56	epoxide hydrolase 1	Homo sapiens	22-25
7884677-4	1994	The slopes of plots of log PRX vs log KRX were 0.85, 0.91, 0.99, and 2.4, respectively, for hexadecane/water, hexadecene/water, 1,9-decadiene/water, and octanol/water with the best model solvent being that which yielded a slope closest to unity.	Water	121-126	periaxin	Homo sapiens	27-30
7884677-4	1994	The slopes of plots of log PRX vs log KRX were 0.85, 0.91, 0.99, and 2.4, respectively, for hexadecane/water, hexadecene/water, 1,9-decadiene/water, and octanol/water with the best model solvent being that which yielded a slope closest to unity.	Water	121-126	periaxin	Homo sapiens	27-30
24657265-2	2014	The cystic fibrosis transmembrane conductance regulator (CFTR) plays an essential role to male fertility and it was recently suggested that it may promote water transport.	Water	155-160	CF transmembrane conductance regulator	Rattus norvegicus	4-55
7982218-3	1994	In the FAB mass spectra, molecular-ion clusters as well as fragment ions corresponding to loss of water or CO2 molecules were observed.	Water	98-103	FA complementation group B	Homo sapiens	7-10
24657265-2	2014	The cystic fibrosis transmembrane conductance regulator (CFTR) plays an essential role to male fertility and it was recently suggested that it may promote water transport.	Water	155-160	CF transmembrane conductance regulator	Rattus norvegicus	57-61
24657265-10	2014	Our results suggest that CFTR physically interacts with AQP4 in rat SCs evidencing a possible mechanism by which CFTR can control water transport through BTB.	Water	130-135	CF transmembrane conductance regulator	Rattus norvegicus	25-29
8073283-3	1994	Glutamine204 (Gln61 in p21ras) stabilizes and orients the hydrolytic water in the trigonal-bipyramidal transition state.	Water	69-74	HRas proto-oncogene, GTPase	Homo sapiens	23-29
24657265-10	2014	Our results suggest that CFTR physically interacts with AQP4 in rat SCs evidencing a possible mechanism by which CFTR can control water transport through BTB.	Water	130-135	aquaporin 4	Rattus norvegicus	56-60
24657265-10	2014	Our results suggest that CFTR physically interacts with AQP4 in rat SCs evidencing a possible mechanism by which CFTR can control water transport through BTB.	Water	130-135	CF transmembrane conductance regulator	Rattus norvegicus	113-117
24295711-6	2014	Upon such encapsulation, these beta-carotene-containing apoferritin nanocomposites were water-soluble.	Water	88-93	ferritin heavy chain 1	Homo sapiens	56-67
7529179-2	1994	Another member of the aquaporin family, WCH-CD, has been found in the apical membrane of collecting duct principal cells and may represent the ADH-sensitive water channel.	Water	157-162	aquaporin 2	Canis lupus familiaris	40-46
24518941-5	2014	When a molecule of water is involved in the Rh2(O2CCF3)4-catalyzed reaction, the 1,2-H shift is significantly promoted, so that the rate-determining step becomes the ring opening of 2-aryl-2H-azirine.	Water	19-24	Rh associated glycoprotein	Homo sapiens	44-47
7920711-5	1994	Surprisingly, expression in Xenopus laevis oocytes revealed that all five PIP mRNAs coded for Hg(2+)-sensitive water transport facilitating activities.	Water	111-116	proline iminopeptidase	Arabidopsis thaliana	74-77
7979173-2	1994	The material, termed PS1, has an average molecular weight of 22.4 kDa, is freely soluble in water, but has low solubility in acetone or ethanol, and is remarkably heat-stable, as is the parent BCG vaccine in terms of high-dose antitumor activity.	Water	92-97	presenilin 1	Mus musculus	21-24
24053164-2	2014	We analyzed the effects of dehydration induced by water deprivation for 3 days on the activities of ERK1/2 and transcription factors, Elk1 and cAMP response element-binding protein (CREB) in vasopressinergic neurons, as well as the distribution and level of the motor protein, kinesin, in the hypothalamo-neurohypophyseal system.	Water	50-55	cAMP responsive element binding protein 1	Rattus norvegicus	143-180
7945519-3	1994	Ibuprofen lysinate (IBL, CAS 57469-76-8) is a water soluble form of ibuprofen for rapid absorption.	Water	46-51	BCAR1 scaffold protein, Cas family member	Homo sapiens	25-28
24053164-2	2014	We analyzed the effects of dehydration induced by water deprivation for 3 days on the activities of ERK1/2 and transcription factors, Elk1 and cAMP response element-binding protein (CREB) in vasopressinergic neurons, as well as the distribution and level of the motor protein, kinesin, in the hypothalamo-neurohypophyseal system.	Water	50-55	cAMP responsive element binding protein 1	Rattus norvegicus	182-186
24363090-0	2014	A synergic role of caspase-6 and caspase-3 in Tau truncation at D421 induced by H2O 2.	Water	80-83	caspase 6	Homo sapiens	19-28
8201386-1	1994	PURPOSE: A phase I trial was performed to evaluate the feasibility of escalating the dose of etoposide in dose-intensive ifosfamide, carboplatin, and etoposide (ICE) with granulocyte-macrophage colony-stimulating factor (GM-CSF).	Water	161-164	colony stimulating factor 2	Homo sapiens	171-219
25007616-6	2014	The O-H oscillation of the crystal water in Tb(2-FBA)3 x 2H2O will greatly consume the absorbed energy by ligands, and cause the fluorescence intensity of Tb(2-FBA)3 x 2H2O significantly decline.	Water	35-40	F-box protein 3	Homo sapiens	49-52
7664051-0	1994	Structural water in oxidized and reduced horse heart cytochrome c.	Water	11-16	cytochrome c, somatic	Equus caballus	53-65
7664051-1	1994	The existence of structural water in the interior of both oxidized and reduced horse-heart cytochrome c in solution is demonstrated using nuclear magnetic resonance spectroscopy.	Water	28-33	cytochrome c, somatic	Equus caballus	91-103
25007616-6	2014	The O-H oscillation of the crystal water in Tb(2-FBA)3 x 2H2O will greatly consume the absorbed energy by ligands, and cause the fluorescence intensity of Tb(2-FBA)3 x 2H2O significantly decline.	Water	35-40	F-box protein 3	Homo sapiens	160-163
25007616-10	2014	It is the only way to compensate for energy loss by thermal vibration of water molecules and low energy transfer efficiency for poor matching degree between the energy level of corresponding to 273 nm of the first ligand 2-FBA and 5D4 energy level of Tb3+.	Water	73-78	F-box protein 3	Homo sapiens	223-226
24186361-7	2014	To this end, we developed a screening assay for Synj1 based on detection of inorganic phosphate liberation from a water-soluble, short-chain PI(4,5)P2.	Water	114-119	synaptojanin 1	Mus musculus	48-53
8188662-8	1994	His64, Gln64, and distal pocket water molecules appear to facilitate deprotonation of HCN, which is the major kinetic barrier to cyanide binding at neutral pH.	Water	32-37	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	86-89
24048380-8	2014	The percent fractional free water clearance with respect to CrCL was significantly but negatively correlated with increasing baseline CrCL.	Water	28-33	CRCL	Homo sapiens	60-64
8161500-1	1994	By suspending bovine rhodopsin in trehalose-water glass films, it is possible to trap photostates in the light-activation process.	Water	44-49	rhodopsin	Bos taurus	21-30
24048380-8	2014	The percent fractional free water clearance with respect to CrCL was significantly but negatively correlated with increasing baseline CrCL.	Water	28-33	CRCL	Homo sapiens	134-138
7520041-1	1994	Two recently cloned water channels, CHIP28 and WCH-CD, are homologous to MIP26, an integral membrane channel-forming protein found in lens fiber plasma membranes.	Water	20-25	aquaporin 2	Homo sapiens	47-53
24561249-3	2014	Overexpression of AtWNK9 from the cauliflower mosaic virus 35S promoter in Arabidopsis resulted in increased sensitivity to ABA, strong inhibition of primary root elongation, increased proline accumulation, reduced stomatal aperture, and a reduced rate of water loss.	Water	256-261	Protein kinase superfamily protein	Arabidopsis thaliana	18-24
8177023-4	1994	In the second step, "bound" PAF, i.e., PAF not extractable with ethanol, is extracted from the protein precipitate with chloroform/methanol/water.	Water	140-145	PCNA clamp associated factor	Homo sapiens	28-31
8177023-4	1994	In the second step, "bound" PAF, i.e., PAF not extractable with ethanol, is extracted from the protein precipitate with chloroform/methanol/water.	Water	140-145	PCNA clamp associated factor	Homo sapiens	39-42
24561249-5	2014	In contrast, a mutant with a T-DNA insertion in AtWNK9 showed reduced ABA sensitivity and an increased rate of water loss; further, it showed increased susceptibility to drought stress.	Water	111-116	Protein kinase superfamily protein	Arabidopsis thaliana	48-54
8992201-0	1996	Ferritin effect on the transverse relaxation of water: NMR microscopy at 9.4 T. Accumulation of ferritin, the iron storage protein, has been linked recently to aging and a number of pathologies.	Water	48-53	ferritin, heavy polypeptide 1, gene 2 L homeolog	Xenopus laevis	0-8
8992201-0	1996	Ferritin effect on the transverse relaxation of water: NMR microscopy at 9.4 T. Accumulation of ferritin, the iron storage protein, has been linked recently to aging and a number of pathologies.	Water	48-53	ferritin, heavy polypeptide 1, gene 2 L homeolog	Xenopus laevis	96-104
8992201-2	1996	The aim of this article is to characterize the effect of ferritin on transverse water relaxation in a high magnetic field, using an imaging Carr-Purcell Meiboom-Gill (CPMG) preparation sequence.	Water	80-85	ferritin, heavy polypeptide 1, gene 2 L homeolog	Xenopus laevis	57-65
8992201-3	1996	Ferritin-induced water relaxation showed quadratic dependence on the iron loading factor, implying a paramagnetic mechanism.	Water	17-22	ferritin, heavy polypeptide 1, gene 2 L homeolog	Xenopus laevis	0-8
8140421-4	1994	A male patient with an autosomal recessive form of NDI was found to be a compound heterozygote for two mutations in the gene encoding aquaporin-2, a water channel.	Water	149-154	aquaporin 2	Homo sapiens	134-145
24365878-8	2014	Organ function and tissue water contents of liver, kidney, and intestine and the intestinal barrier ZO-1 density were also improved in group P1 and group P2, compared with group LA.	Water	26-31	perforin 1	Rattus norvegicus	141-156
7516776-1	1994	Human microsomal epoxide hydrolase (mEH) is a biotransformation enzyme that metabolizes reactive epoxide intermediates to more water-soluble trans-dihydrodiol derivatives.	Water	127-132	epoxide hydrolase 1	Homo sapiens	6-34
24481318-5	2014	In addition, CdS assemblies exhibit superior photocatalytic activities by the photodegradation of eosin B, Methyl orange (MO) and Rhodamine B (RhB) under visible light irradiation, with a comparison with other CdS nanostructures, P25 and alpha-Fe2O3 powders, demonstrating potential applications in removal of organic dye molecules from waste water.	Water	343-348	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
8011980-1	1994	The capillary leak syndrome with decreased GFR and renal water and sodium retention after recombinant interleukin-2 (IL-2) administration may arise from endothelial activation via an increase in prostaglandin synthesis.	Water	57-62	interleukin 2	Rattus norvegicus	102-115
8011980-1	1994	The capillary leak syndrome with decreased GFR and renal water and sodium retention after recombinant interleukin-2 (IL-2) administration may arise from endothelial activation via an increase in prostaglandin synthesis.	Water	57-62	interleukin 2	Rattus norvegicus	117-121
8904243-9	1996	Water channel aquaporin of collecting duct (AQP-2) was cloned and characterized, which is localized in chromosome 12q13.	Water	0-5	aquaporin 2	Homo sapiens	44-49
24452376-1	2014	Regulated urine concentration takes place in the renal collecting duct upon arginine vasopressin (AVP) stimulation, where subapical vesicles containing aquaporin-2 (AQP2) are inserted into the apical membrane instantly increasing water reabsorption and urine concentration.	Water	230-235	aquaporin 2	Homo sapiens	152-163
21544351-3	1996	Tea is grown in about 30 countries and, next to water, is the most widely consumed beverage in the world.	Water	48-53	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
8133054-9	1994	Even though C4BP, C4(H2O), and SAP form a multimolecular complex in fluid phase, SAP was found to inhibit binding of C4BP to immobilized C4(H2O).	Water	21-24	amyloid P component, serum	Homo sapiens	81-84
8133054-9	1994	Even though C4BP, C4(H2O), and SAP form a multimolecular complex in fluid phase, SAP was found to inhibit binding of C4BP to immobilized C4(H2O).	Water	140-143	amyloid P component, serum	Homo sapiens	31-34
8133054-9	1994	Even though C4BP, C4(H2O), and SAP form a multimolecular complex in fluid phase, SAP was found to inhibit binding of C4BP to immobilized C4(H2O).	Water	140-143	amyloid P component, serum	Homo sapiens	81-84
21544351-5	1996	Majority of these studies have been carried out in skin tumor model system where consumption through drinking water of water extracts of tea or a polyphenolic fraction isolated from tea has been shown to afford protection against chemical carcinogen- or ultraviolet radiation-induced skin tumorigenesis.	Water	110-115	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	137-140
21544351-5	1996	Majority of these studies have been carried out in skin tumor model system where consumption through drinking water of water extracts of tea or a polyphenolic fraction isolated from tea has been shown to afford protection against chemical carcinogen- or ultraviolet radiation-induced skin tumorigenesis.	Water	110-115	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	182-185
8133054-11	1994	Heparin, which is known to inhibit the interaction between SAP and C4BP, was also found to counteract the inhibitory effect of SAP on C4BP binding to C4(H2O).	Water	153-156	amyloid P component, serum	Homo sapiens	59-62
8133054-11	1994	Heparin, which is known to inhibit the interaction between SAP and C4BP, was also found to counteract the inhibitory effect of SAP on C4BP binding to C4(H2O).	Water	153-156	amyloid P component, serum	Homo sapiens	127-130
21544351-5	1996	Majority of these studies have been carried out in skin tumor model system where consumption through drinking water of water extracts of tea or a polyphenolic fraction isolated from tea has been shown to afford protection against chemical carcinogen- or ultraviolet radiation-induced skin tumorigenesis.	Water	119-124	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	137-140
21544351-5	1996	Majority of these studies have been carried out in skin tumor model system where consumption through drinking water of water extracts of tea or a polyphenolic fraction isolated from tea has been shown to afford protection against chemical carcinogen- or ultraviolet radiation-induced skin tumorigenesis.	Water	119-124	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	182-185
24452376-1	2014	Regulated urine concentration takes place in the renal collecting duct upon arginine vasopressin (AVP) stimulation, where subapical vesicles containing aquaporin-2 (AQP2) are inserted into the apical membrane instantly increasing water reabsorption and urine concentration.	Water	230-235	aquaporin 2	Homo sapiens	165-169
24452376-2	2014	The reabsorped water exits via basolateral AQP3 and AQP4.	Water	15-20	aquaporin 3 (Gill blood group)	Homo sapiens	43-47
24452376-4	2014	To facilitate the increase in transepithelial water transport, AQP3 may be short-term regulated via changes in protein-protein interactions, incorporation into lipid rafts, and/or changes in steady-state turnover, which could result in changes in the diffusion behavior of AQP3.	Water	46-51	aquaporin 3 (Gill blood group)	Homo sapiens	63-67
8769832-3	1996	A constant intrarenal infusion of ANG-(1-7) at 0.1 and 1 nmol.min-1.kg-1 had minimal effects on renal blood flow and blood pressure and resulted in an elevated urinary excretion of Na and water compared with the time-control saline-infused group.	Water	188-193	angiopoietin 1	Rattus norvegicus	34-42
8114094-0	1994	The role of a conserved internal water molecule and its associated hydrogen bond network in cytochrome c. High resolution three-dimensional structures for the N52I and N52I-Y67F yeast iso-1-cytochrome c variants have been completed in both oxidation states.	Water	33-38	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	184-189
8114094-2	1994	In wild-type yeast iso-1-cytochrome c the position and orientation of this water molecule is found to be dependent on the oxidation state of the heme iron atom.	Water	75-80	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	19-24
8769832-8	1996	Together these findings indicate that ANG-(1-7) has biological activity in the kidney and, at nonvasoconstrictor doses, results in increased Na and water excretion in vivo.	Water	148-153	angiopoietin 1	Rattus norvegicus	38-46
8769840-7	1996	These findings indicate that renal vasodilator, diuretic, and natriuretic responses to ADM may be mediated by the release of endogenous NO and suggest that ADM could play a role in regulating water and electrolyte excretion by the kidney.	Water	192-197	adrenomedullin	Canis lupus familiaris	87-90
8769840-7	1996	These findings indicate that renal vasodilator, diuretic, and natriuretic responses to ADM may be mediated by the release of endogenous NO and suggest that ADM could play a role in regulating water and electrolyte excretion by the kidney.	Water	192-197	adrenomedullin	Canis lupus familiaris	156-159
24533995-1	2014	Large amounts of waste water are discharged from the Jeddah Metropolitan Area into the Red Sea.	Water	23-28	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	91-94
8081746-0	1994	Localization of bound water in the solution structure of a complex of the erythroid transcription factor GATA-1 with DNA.	Water	22-27	GATA binding protein 1 (globin transcription factor 1)	Gallus gallus	105-111
8081746-5	1994	Solvation free energy calculations, however, suggest that hydrophobic interactions should exclude water from parts of the GATA-1:DNA interface.	Water	98-103	GATA binding protein 1 (globin transcription factor 1)	Gallus gallus	122-128
8081746-6	1994	RESULTS: Using water-selective two-dimensional heteronuclear magnetic resonance spectroscopy, we have identified the location of bound water molecules in the specific complex of chicken GATA-1 with DNA.	Water	15-20	GATA binding protein 1 (globin transcription factor 1)	Gallus gallus	186-192
8081746-6	1994	RESULTS: Using water-selective two-dimensional heteronuclear magnetic resonance spectroscopy, we have identified the location of bound water molecules in the specific complex of chicken GATA-1 with DNA.	Water	135-140	GATA binding protein 1 (globin transcription factor 1)	Gallus gallus	186-192
24473238-0	2014	Reaction of a charge-separated ONONO2 species with water in the formation of HONO: an MP2 Molecular Dynamics study.	Water	51-56	tryptase pseudogene 1	Homo sapiens	86-89
8162968-4	1994	EAU was induced in 72 Lewis rats by two footpad injections of S-Ag.	Water	0-3	S-antigen visual arrestin	Rattus norvegicus	62-66
8815812-4	1996	Aquaporin-2 mediates vasopressin-dependent renal collecting duct water permeability; mutations or downregulation can cause nephrogenic diabetes insipidus.	Water	65-70	aquaporin 2	Homo sapiens	0-11
8815812-5	1996	Aquaporin-3 in the basolateral membrane of the collecting duct provides an exit pathway for reabsorbed water.	Water	103-108	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
24626462-2	2014	Surprisingly, compared to Cd alone, SNP and PTIO elevated Cd uptake (confirmed also by PhenGreen staining) but depleted glutathione (partially ascorbic acid) and phytochelatins PC2 and PC3 in both older plants (cultured hydroponically) and seedlings (cultured in deionised water).	Water	273-278	chromobox 8	Homo sapiens	185-188
8723314-5	1996	In contrast, the reaction of lysozyme with the specific monoclonal antibody D44.1, or its Fab, showed the inverse effect: a small increase in the value of the association constant with decreasing water molarities.	Water	196-201	FA complementation group B	Homo sapiens	90-93
17839182-1	1994	By providing cold, dense water that sinks and mixes to fill the abyssal world ocean, high-latitude air-sea-ice interaction is the main conduit through which the deep ocean communicates with the rest of the climate system.	Water	25-30	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	103-106
29930830-9	2014	Regression analysis revealed a significant relationship between the interval and water temperature (r2 = 0.96, P &lt; 0.01), and a Cox proportional hazard analysis revealed that water temperature was a significant predictor (adjusted odds ratio, 23.9; 95% confidence interval, 7.4-77.2).	Water	178-183	coproporphyrinogen oxidase	Rattus norvegicus	131-134
7508187-1	1994	The cloning and expression of an apical membrane water channel from rat kidney collecting duct (WCH-CD) homologous to a 28-kDa integral membrane protein (CHIP28) was reported recently (K. Fushimi, S. Uchida, Y. Hara, Y. Hirata, F. Marumo, and S. Sasaki.	Water	49-54	aquaporin 2	Rattus norvegicus	96-102
8818115-1	1996	Aquaporin-2 (AQP-2) has been shown to be a vasopressin-sensitive water channel in collecting duct (CD) cells of the kidney.	Water	65-70	aquaporin 2	Rattus norvegicus	0-11
24533623-8	2014	On the other hand, the same complexes Pt1O and Pt2 were also produced in the degassed solution, probably because of the reaction of the photoexcited Pt1* with the biradical character and H2O.	Water	187-190	zinc finger protein 77	Homo sapiens	38-41
8818115-1	1996	Aquaporin-2 (AQP-2) has been shown to be a vasopressin-sensitive water channel in collecting duct (CD) cells of the kidney.	Water	65-70	aquaporin 2	Rattus norvegicus	13-18
7764529-4	1994	The resulting SP and SS group-containing membranes, designated as SP-T and SS-T fibers, respectively, had 95 and 77% water flux of the original membrane, respectively.	Water	117-122	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	66-70
24378774-5	2014	In particular, renal ACE and locally generated angiotensin II affect the activity of several key sodium transporters and the induction of sodium and water retention resulting in the elevation of BP.	Water	149-154	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	21-24
7540079-4	1994	It was found that rh G-CSF 25 micrograms administered into the subcutaneous tissue of rabbits increased extravascular lung water to 3.45 +/- 0.26 vs 2.98 +/- 0.20 in control experiments (P &lt; 0.05); however, rhG-CSF 0.75 microgram/kg administered into the alveolar spaces did not affect liquid clearance from the alveolar spaces.	Water	123-128	colony stimulating factor 3	Homo sapiens	21-26
8742842-36	1996	TRANSPORT AND DISTRIBUTION: Despite differences in water solubility of the two isomers (trans-DDP less soluble), this property is unlikely to be important at physiological concentrations...	Water	51-56	translocase of inner mitochondrial membrane 8A	Homo sapiens	94-97
24412547-1	2014	ETHNOPHARMACOLOGICAL RELEVANCE: Aquaporin-3 (AQP3) is expressed in mucosal epithelial cells in the colon and is important for regulating fecal water content.	Water	143-148	aquaporin 3 (Gill blood group)	Homo sapiens	45-49
8594871-0	1995	Distribution of aquaporin-4 water channel expression within rat kidney.	Water	28-33	aquaporin 4	Rattus norvegicus	16-27
8594871-3	1995	We prepared affinity-purified polyclonal antipeptide antibodies to AQP4 to define the regional distribution and cellular location of this water channel within the kidney.	Water	138-143	aquaporin 4	Rattus norvegicus	67-71
7505572-1	1993	Two kidney water channels have been identified: CHIP28 in proximal tubule and thin descending limb, and WCH-CD in collecting duct apical membrane.	Water	11-16	aquaporin 2	Rattus norvegicus	104-110
24761047-2	2014	AQP7 and AQP9 are membrane proteins with water and glycerol channels, the latter of which is essential for triglyceride synthesis.	Water	41-46	aquaporin 7	Mus musculus	0-4
8269547-3	1993	Qualitatively they result in separation of the initial irreversible 4 electron reduction into two stages, the NO2/RNO2.- and RNO2.-, 4H/RNHOH, H2O couples, respectively.	Water	143-146	NLR family pyrin domain containing 12	Homo sapiens	125-129
8594871-10	1995	These results suggest a possible role for AQP4 in the basolateral exit of water from the IMCD.	Water	74-79	aquaporin 4	Rattus norvegicus	42-46
8719928-3	1995	In vitro studies suggested that guanylin plays an important role in the endogenous modulation of intestinal salt and water secretion.	Water	117-122	guanylate cyclase activator 2A	Homo sapiens	32-40
8218260-0	1993	Acid-induced unfolding and refolding transitions of cytochrome c: a three-state mechanism in H2O and D2O.	Water	93-96	cytochrome c, somatic	Equus caballus	52-64
8218260-7	1993	To examine the proposed difference in the conformational transitions, we carried out the HCl and DCl titrations of cytochrome c in H2O and D2O, respectively, measured by far-UV circular dichroism, tryptophan fluorescence, and Soret absorption.	Water	131-134	cytochrome c, somatic	Equus caballus	115-127
24761047-2	2014	AQP7 and AQP9 are membrane proteins with water and glycerol channels, the latter of which is essential for triglyceride synthesis.	Water	41-46	aquaporin 9	Mus musculus	9-13
24574031-1	2014	The reaction of fac-[M(III)F3(Me3tacn)] x H2O with Gd(NO3)3 5H2O affords a series of fluoride-bridged, trigonal bipyramidal {Gd(III)3M(III)2} (M = Cr (1), Fe (2), Ga (3)) complexes without signs of concomitant GdF3 formation, thereby demonstrating the applicability even of labile fluoride-complexes as precursors for 3d-4f systems.	Water	42-45	growth differentiation factor 3	Homo sapiens	210-214
8238623-2	1993	Intracerebroventricular injection of 6, 12, and 20 ng ET-2 resulted in a significant, dose-related inhibition of water drinking in response to subsequent injection of 100 pmol angiotensin II (ANG II).	Water	113-118	endothelin 2	Rattus norvegicus	54-58
8748136-3	1995	The serum levels of hIGFBP-3 increased as the mice were bred to homozygosity and were further induced by supplementing the drinking water with 25 mM ZnCl2.	Water	132-137	insulin like growth factor binding protein 3	Homo sapiens	20-28
8111229-0	1993	Measurement of amide proton exchange rates and NOEs with water in 13C/15N-enriched calcineurin B.	Water	57-62	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	83-96
24374286-3	2014	In the present study, we found that SNAP-25 phosphorylation increased rapidly in the mouse brain following cold-water restraint stress.	Water	112-117	synaptosomal-associated protein 25	Mus musculus	36-43
24460028-0	2014	The presence of an air-water interface affects formation and elongation of alpha-Synuclein fibrils.	Water	23-28	synuclein alpha	Homo sapiens	75-90
8415667-1	1993	Molecular dynamics (MD) simulation covering a wide range of hydration indicate that myoglobin is fully hydrated by 350 water molecules, in agreement with experiment.	Water	119-124	myoglobin	Homo sapiens	84-93
7503232-0	1995	Aquaporin-3 water channel localization and regulation in rat kidney.	Water	12-17	aquaporin 3 (Gill blood group)	Rattus norvegicus	0-11
7503232-19	1995	These studies are consistent with a role for AQP-3 in osmotically driven water absorption across the collecting duct epithelium and suggest that the expression of AQP-3 is regulated on a long-term basis.	Water	73-78	aquaporin 3 (Gill blood group)	Rattus norvegicus	45-50
24460028-3	2014	In this work the effect of the air-water interface (AWI) on alpha-Syn aggregation is investigated by means of thioflavin T binding measurements, dynamic light scattering, size-exclusion chromatography, electron microscopy, and atomic force microscopy.	Water	35-40	synuclein alpha	Homo sapiens	60-69
8375542-5	1993	However, CD-1 embryos were shown to be sensitive to variations in water quality, pH, temperature, incubator conditions, and contaminants in the system when grown in a protein-free medium optimized for their development.	Water	66-71	CD1 antigen complex	Mus musculus	9-13
24366483-3	2014	The equilibrium geometry of benzoic acid-water was determined with ab initio calculations, at the B3LYP, M06-2X, and MP2 levels of theory, with the 6-311++G(2df,2pd) basis set.	Water	41-46	tryptase pseudogene 1	Homo sapiens	117-120
8220493-5	1993	Elevated GRP gene mRNA levels could be detected within 15 min of glucan treatment and reached maximum levels at 4 h post-treatment followed by a slow decline to 8 h. The maximum induction of the GRP gene was approximately ninefold above H2O-treated control plants.	Water	237-240	glycine-rich protein	Nicotiana tabacum	9-12
8739267-3	1995	The behavior of the NMR signal and the measured ADC are greatly affected by the cellular architecture of a tissue, mainly because cellular membranes are relatively impermeable to water.	Water	179-184	antizyme inhibitor 2	Homo sapiens	48-51
7578021-5	1995	The water structure is identical in rhodopsin and isorhodopsin.	Water	4-9	rhodopsin	Bos taurus	36-45
8220493-5	1993	Elevated GRP gene mRNA levels could be detected within 15 min of glucan treatment and reached maximum levels at 4 h post-treatment followed by a slow decline to 8 h. The maximum induction of the GRP gene was approximately ninefold above H2O-treated control plants.	Water	237-240	glycine-rich protein	Nicotiana tabacum	195-198
7578025-1	1995	Phosphorylation of phosphoinositides by phosphoinositide 3"-hydroxykinase (PI3K) occurs at a lipid/water interface.	Water	99-104	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	40-73
24366483-11	2014	Using monitoring data from Calgary, Alberta, and the MP2-predicted dissociation energy, a yearly average of 1% of benzoic acid is expected to be present in the form of benzoic acid-water.	Water	181-186	tryptase pseudogene 1	Homo sapiens	53-56
7560075-1	1995	Colocalization with Aquaporin-2 water channels.	Water	32-37	aquaporin 2	Homo sapiens	20-31
24295640-0	2014	Effects of Cagemate Gender and the Cagemate"s access to ethanol on ethanol and water intake of the proximal male or the proximal female CD-1 mouse.	Water	79-84	CD1 antigen complex	Mus musculus	136-140
8345200-3	1993	Together with vitronectin, clusterin binds to the nascent amphiphilic C5b-9 complex, rendering it water soluble and lytically inactive.	Water	98-103	complement C5	Homo sapiens	70-73
24305472-9	2014	We also provide ancillary in vitro data in rat inner-medullary-collecting-duct suspensions showing that tolvaptan can block vasopressin"s effects on phosphorylation of the water channel AQP2 in vitro.	Water	172-177	aquaporin 2	Rattus norvegicus	186-190
24202502-6	1993	Insulin also stimulated (3)H2O incorporation into total lipid in a dose-dependent manner.	Water	27-30	insulin	Bos taurus	0-7
8576941-8	1995	Vesnarinone at 26 mumol/l and NKH477 at 10 mumol/l, a water soluble forskolin derivative used as a positive control, both significantly inhibited the expression of E-selectin induced by 10 ng/ml of human tumor necrosis factor (TNF)-alpha.	Water	54-59	selectin E	Homo sapiens	164-174
8569067-7	1995	In the collecting duct, AQP2 is the predominant vasopressin-sensitive water channel.	Water	70-75	aquaporin 2	Homo sapiens	24-28
24291287-0	2014	Dielectric spectroscopy study of myoglobin in glycerol-water mixtures.	Water	55-60	myoglobin	Homo sapiens	33-42
8569067-10	1995	AQP3 resides in the basolateral membranes of collecting duct principal cells providing an exit pathway for water, and AQP4 is abundant in brain, where it apparently functions as the hypothalamic osmoreceptor responsible for secretion of antidiuretic hormone.	Water	107-112	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
8569068-2	1995	In the kidney, proximal-type (CHIP28) and collecting duct (WCH-CD) water channels have been identified.	Water	67-72	aquaporin 2	Homo sapiens	59-65
8440194-8	1993	Fourth, P450arom activity was measured in germ cells by the 3H2O water assay.	Water	65-70	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	8-16
8217552-2	1993	Our data confirm that choroidal mast cell numbers decrease with clinical onset of S-antigen-induced EAU in Lewis rats, and establish that the decrease is statistically significant.	Water	100-103	S-antigen visual arrestin	Rattus norvegicus	82-91
8217552-3	1993	In addition, we find that the numbers of limbal mast cells also decrease during S-antigen-induced EAU, and that this decrease occurs earlier in the course of the disease than that observed for choroidal mast cells.	Water	98-101	S-antigen visual arrestin	Rattus norvegicus	80-89
7671343-6	1995	Rat liver cytosol and microsomes, and various purified rat and human GSTs extensively metabolized DBCP to water soluble metabolites in the presence of GSH.	Water	106-111	glutathione S-transferase kappa 1	Homo sapiens	69-73
8430955-6	1993	This procedure was repeated on separate occasions, each at least 14 days apart, except that the sheep were treated with an aerosol of catalase (CAT; 38 mg in 3 ml deionized water), the enzyme that catalyzes the decomposition of hydrogen peroxide (H2O2), at three different times: Trial 1, before antigen and then every 30 min after antigen challenge for 2 h; Trial II, 1 and 2 h after antigen challenge; and Trial III, only at 2 h after antigen challenge.	Water	173-178	catalase	Ovis aries	134-142
24291287-3	2014	Solutions of myoglobin in glycerol/water mixtures of various compositions are measured by dielectric spectroscopy in the frequency range from 10mHz to 10MHz.	Water	35-40	myoglobin	Homo sapiens	13-22
8430955-6	1993	This procedure was repeated on separate occasions, each at least 14 days apart, except that the sheep were treated with an aerosol of catalase (CAT; 38 mg in 3 ml deionized water), the enzyme that catalyzes the decomposition of hydrogen peroxide (H2O2), at three different times: Trial 1, before antigen and then every 30 min after antigen challenge for 2 h; Trial II, 1 and 2 h after antigen challenge; and Trial III, only at 2 h after antigen challenge.	Water	173-178	catalase	Ovis aries	144-147
24338365-8	2014	We conclude that water fluxes accompanying CFTR activity are linked to AQP3 but not to a cAMP-stimulated aqueous pore in the CFTR protein.	Water	17-22	aquaporin 3 (Gill blood group)	Homo sapiens	71-75
24351121-1	2014	Water confinement in the hydrophobic nanopores of highly siliceous zeolite having MFI and CHA topology is investigated by high pressure manometry coupled to differential calorimetry.	Water	0-5	transcription factor like 5	Homo sapiens	90-93
24351121-2	2014	Surprisingly, the intrusion of water is endothermic for MFI but exothermic for CHA.	Water	31-36	transcription factor like 5	Homo sapiens	79-82
8386360-1	1993	The structure of human corticotropin releasing factor (hCRF) has been determined by proton nuclear magnetic resonance (1H NMR) in a mixed-solvent system of 66% trifluoroethanol/34% H2O at pH 3.8 and 37 degrees C. Nearly complete resonance assignment was achieved by using standard two-dimensional methods.	Water	181-184	corticotropin releasing hormone	Homo sapiens	23-53
25268246-2	2014	AP5-glycol spontaneously formed bilayer vesicles in water, and these vesicles were still stable after several weeks.	Water	52-57	adaptor related protein complex 5 subunit beta 1	Homo sapiens	0-3
7677994-0	1993	The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel.	Water	60-65	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	53-59
7653554-4	1995	IGF-I and/or GH increased carcass protein and water while decreasing fat.	Water	46-51	insulin-like growth factor 1	Rattus norvegicus	0-5
24419384-2	2014	The level of detail around the metal centres in these structures was highly limited, and the coordination of water in Cu site II of the copper insulin derivative was deteriorated as a consequence of radiation damage.	Water	109-114	insulin	Bos taurus	143-150
8548396-0	1995	Heavy water activates monocyte generation of tissue factor.	Water	6-11	coagulation factor III, tissue factor	Homo sapiens	45-58
7677994-2	1993	Molecular identification of CHIP28 protein as the membrane water channel was first accomplished by measurement of osmotic swelling of Xenopus oocytes injected with CHIP28 RNA (Preston, G.M., Carroll, T.P., Guggino, W.B., and Agre, P. (1992) Science 256, 385-387).	Water	59-64	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	28-34
7677994-7	1993	These studies demonstrated: (i) CHIP28 water channel activity is retained despite substitution of individual cysteines with serine; (ii) cysteine 189 is the Hg(2+)-sensitive residue; (iii) the subunits of the CHIP28 complex are individually active water pores; (iv) residue 189 is critical to proper processing of the CHIP28 protein.	Water	39-44	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	32-38
8430834-15	1993	The specific localization to these cells suggests a possible role for the 5-HT1A receptor in the regulation of salt and water transport in mammalian kidney.	Water	120-125	5-hydroxytryptamine receptor 1A	Homo sapiens	74-89
23876228-5	2014	RESULTS: Compared to A-allele homozygotes, G-allele carriers of the OPRM1 gene showed (i) greater activation of the insula and orbitofrontal cortex and (ii) stronger negative fronto-striatal functional connectivity for both ventral and dorsal striatal seed regions during processing of alcohol versus water cues.	Water	301-306	opioid receptor mu 1	Homo sapiens	68-73
7546503-7	1995	With the subsequent reverse-phase HPLC of fraction IV/8 a polar OLF-1 eluted in fraction IV/8a after the void volume in the water phase and a more apolar OLF-2 eluted at 20% acetonitrile in fraction IV/8d.	Water	124-129	EBF transcription factor 1	Homo sapiens	64-69
8281562-2	1993	Fifty-three children were from Dambulla, Sri Lanka, and 44 from Newcastle, England, both localities receiving drinking water containing 0.8-1.1 mgF/l.	Water	119-124	signal transducer and activator of transcription 5A	Homo sapiens	144-147
25478577-10	2014	Thus, among the ionic changes induced by ischemia, the decrease in extracellular Ca2+ causes failure of the high-K+-stimulated Na+,K+-ATPase/NKCC1 ion/water uptake, making beta1-adrenergic activation the only stimulus and its inhibition effective against edema.	Water	151-156	solute carrier family 12 member 2	Homo sapiens	141-146
8383554-1	1993	At the concentration needed for NMR, the calcium-saturated form of calcineurin B dissolved in water shows resonance line widths that indicate aggregation of this protein.	Water	94-99	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	67-80
7631892-3	1995	By contrast, water intake and urine volume were markedly elevated in the TTR-ANF group on either diet.	Water	13-18	natriuretic peptide type A	Mus musculus	77-80
25045689-5	2014	It was concluded that the different stability of the studied complexes affords two distinct drug delivery systems: in the case of MTP, the dissociation of the complex, as a consequence of the interaction with water, affords a classical soluble matrix type delivery system; in the case of DTZ, the dissolving/diffusing species is the complex itself because of the very strong interaction between the drug and the polymer.	Water	209-214	metallothionein 1B	Homo sapiens	130-133
7541037-10	1995	For reactions assembled on phospholipid membranes, delta G* increased with delta II at a ratio of 0.35 +/- 0.05 kcal/mol/atm, corresponding to 814 +/- 116 mol of water tansferred from bulk solution to protein surfaces.	Water	162-167	ATM serine/threonine kinase	Homo sapiens	121-124
7597055-5	1995	The presence of guanylin in the lung and particularly its specific localization to Clara cells indicate that these cells may play a pivotal role in the local (paracrine) regulation of electrolyte/water transport in airway epithelia.	Water	196-201	guanylate cyclase activator 2A	Homo sapiens	16-24
8127945-2	1993	This experiment investigates the effect of administering an analog of luteinizing hormone-releasing hormone (LHRH), D-Trp6-LHRH, to 22-mo-old female rats submitted to successive trainings in a water-reinforced matching to sample task since the age of three months.	Water	193-198	gonadotropin releasing hormone 1	Rattus norvegicus	70-107
8127945-2	1993	This experiment investigates the effect of administering an analog of luteinizing hormone-releasing hormone (LHRH), D-Trp6-LHRH, to 22-mo-old female rats submitted to successive trainings in a water-reinforced matching to sample task since the age of three months.	Water	193-198	gonadotropin releasing hormone 1	Rattus norvegicus	109-113
1361949-9	1992	The crystal structures show the B13 Gln side-chains only contact water in contrast to the B13 glutamate in 2Zn insulin.	Water	65-70	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	32-35
24268540-3	2014	DapL is found in specific eubacterial and archaeal lineages, in particular in several groups of pathogenic bacteria such as Leptospira interrogans (LiDapL), the soil/water bacterium Verrucomicrobium spinosum (VsDapL) and the alga Chlamydomonas reinhardtii (CrDapL).	Water	166-171	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	0-4
1285840-3	1992	As in other DHFR complexes, MTXT is interpreted as protonated at N(1) by Glu-30, and the 2-amino group is hydrogen bonded to a structurally conserved water which also interacts with Glu-30 and Thr-136.	Water	150-155	dihydrofolate reductase	Homo sapiens	12-16
7638802-12	1995	In patients with diaphragm weakness (low sniff PDI) TW PM was &lt; 10 cm H2O.	Water	73-76	peptidyl arginine deiminase 1	Homo sapiens	47-50
24717924-2	2014	AQP3, AQP7, and AQP9, termed aqua-glyceroporins, are known to be involved in the transport of water, glycerol, and other small molecules.	Water	94-99	aquaporin 3 (Gill blood group)	Rattus norvegicus	0-4
11607539-6	1995	This protein is a catalase, and binding of SA and its biologically active analogues inhibited catalase"s ability to convert H2O2 to O2 and H2O.	Water	124-127	catalase isozyme 1	Nicotiana tabacum	18-26
11607539-6	1995	This protein is a catalase, and binding of SA and its biologically active analogues inhibited catalase"s ability to convert H2O2 to O2 and H2O.	Water	124-127	catalase isozyme 1	Nicotiana tabacum	94-102
1489092-0	1992	Carbohydrate analysis of water-soluble uronic acid-containing polysaccharides with high-performance anion-exchange chromatography using methanolysis combined with TFA hydrolysis is superior to four other methods.	Water	25-30	coagulation factor III, tissue factor	Homo sapiens	163-166
24662389-7	2014	CONCLUSION: The role of GTP as a regulator of AQP5-mediated water transport in renal cells is of great importance in the physiology of renal epithelia, due to its possible physiopathological implications.	Water	60-65	aquaporin 5	Homo sapiens	46-50
1489092-1	1992	Sulfuric acid hydrolysis according to the Saeman procedure, TFA hydrolysis, and methanolysis combined with TFA hydrolysis were compared for the hydrolysis of water-soluble uronic acid-containing polysaccharides originating from fungi, plants, and animals.	Water	158-163	coagulation factor III, tissue factor	Homo sapiens	107-110
1489092-8	1992	Methanolysis followed by TFA hydrolysis of 20 micrograms water-soluble uronic acid containing polysaccharides and subsequent analysis of the liberated sugar residues by HPAEC allowed us to determine the carbohydrate composition of these polysaccharides rapidly and accurately in one assay without the need for derivatization.	Water	57-62	coagulation factor III, tissue factor	Homo sapiens	25-28
7552242-5	1995	The reductions in MAP-2 and synaptophysin-IR were reversed by 3 days of treatment with dexamethasone (10 mg/l drinking water) or ipsapirone, a 5-HT1A agonist (1 mg/kg s.c.).	Water	119-124	microtubule-associated protein 2	Rattus norvegicus	18-23
24134893-8	2014	The CDOM in the pore water increased along the river to the coastal area, which was mainly influenced by C1 and C3 and was significantly derived from sediment remineralization and deposition from the inflow of the Yangtze River.	Water	21-26	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	105-114
7724588-6	1995	In addition, binding energy was provided through a water molecule that formed hydrogen bonds to both N7 of dGMP and the hydroxyl of Tyr-94.	Water	51-56	fliF	Drosophila melanogaster	107-111
1429633-3	1992	Mutations, His--&gt;Val and His--&gt;Leu, remove the heme-bound water molecule resulting in a five-coordinate heme iron at neutral pH, while the heme-bound water molecule appears to be retained in the engineered myoglobin with His--&gt;Gln substitution as in the wild-type protein.	Water	64-69	myoglobin	Homo sapiens	212-221
1460787-0	1992	[A 4 degrees C-1 min method of cold water immersion test for peripheral circulatory function in fingers].	Water	36-41	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	13-16
7540850-4	1995	Aquaporin 1 (AQP1), aquaporin 2 (AQP2) and the mercury-insensitive water channel (MIWC) are water-selective channel proteins, whereas the fourth, referred to as aquaporin 3 (AQP3), permits transport of urea and glycerol as well.	Water	67-72	aquaporin 3 (Gill blood group)	Homo sapiens	161-172
24920051-0	2014	Eco-efficient one-pot synthesis of quinazoline-2,4(1H,3H)-diones at room temperature in water.	Water	88-93	ciliogenesis associated kinase 1	Homo sapiens	0-3
7707376-0	1995	Detection of long-lived bound water molecules in complexes of human dihydrofolate reductase with methotrexate and NADPH.	Water	30-35	dihydrofolate reductase	Homo sapiens	68-91
7707376-1	1995	The locations of long-lived bound water molecules in the binary complex of human dihydrofolate reductase (hDHFR) with methotrexate (MTX) and the ternary complex of hDHFR with MTX and NADPH have been investigated using 15N-resolved, three-dimensional ROESY-HMQC and NOESY-HSQC spectra acquired at 25 degrees C and 8 degrees C. NOEs with NH groups of the protein are detected for five bound water molecules in the binary complex and six bound water molecules in the ternary complex.	Water	34-39	dihydrofolate reductase	Homo sapiens	81-104
7707376-1	1995	The locations of long-lived bound water molecules in the binary complex of human dihydrofolate reductase (hDHFR) with methotrexate (MTX) and the ternary complex of hDHFR with MTX and NADPH have been investigated using 15N-resolved, three-dimensional ROESY-HMQC and NOESY-HSQC spectra acquired at 25 degrees C and 8 degrees C. NOEs with NH groups of the protein are detected for five bound water molecules in the binary complex and six bound water molecules in the ternary complex.	Water	34-39	dihydrofolate reductase	Homo sapiens	106-111
1400331-2	1992	Most missense mutations of the lipoprotein lipase (LPL) gene identified among LPL-deficient subjects cluster in a segment of the sequence that encodes the catalytic triad as well as functional elements involved in the activation of the lipase at lipid-water interfaces.	Water	252-257	lipoprotein lipase	Homo sapiens	31-49
1400331-2	1992	Most missense mutations of the lipoprotein lipase (LPL) gene identified among LPL-deficient subjects cluster in a segment of the sequence that encodes the catalytic triad as well as functional elements involved in the activation of the lipase at lipid-water interfaces.	Water	252-257	lipoprotein lipase	Homo sapiens	51-54
7707376-1	1995	The locations of long-lived bound water molecules in the binary complex of human dihydrofolate reductase (hDHFR) with methotrexate (MTX) and the ternary complex of hDHFR with MTX and NADPH have been investigated using 15N-resolved, three-dimensional ROESY-HMQC and NOESY-HSQC spectra acquired at 25 degrees C and 8 degrees C. NOEs with NH groups of the protein are detected for five bound water molecules in the binary complex and six bound water molecules in the ternary complex.	Water	34-39	dihydrofolate reductase	Homo sapiens	164-169
24920051-5	2014	This is an eco-efficient method because all the reactions were carried out in water, and the desired products were obtained simply by filtration.	Water	78-83	ciliogenesis associated kinase 1	Homo sapiens	11-14
7707376-1	1995	The locations of long-lived bound water molecules in the binary complex of human dihydrofolate reductase (hDHFR) with methotrexate (MTX) and the ternary complex of hDHFR with MTX and NADPH have been investigated using 15N-resolved, three-dimensional ROESY-HMQC and NOESY-HSQC spectra acquired at 25 degrees C and 8 degrees C. NOEs with NH groups of the protein are detected for five bound water molecules in the binary complex and six bound water molecules in the ternary complex.	Water	389-394	dihydrofolate reductase	Homo sapiens	164-169
7707376-1	1995	The locations of long-lived bound water molecules in the binary complex of human dihydrofolate reductase (hDHFR) with methotrexate (MTX) and the ternary complex of hDHFR with MTX and NADPH have been investigated using 15N-resolved, three-dimensional ROESY-HMQC and NOESY-HSQC spectra acquired at 25 degrees C and 8 degrees C. NOEs with NH groups of the protein are detected for five bound water molecules in the binary complex and six bound water molecules in the ternary complex.	Water	389-394	dihydrofolate reductase	Homo sapiens	164-169
7707376-2	1995	Inspection of crystal structures of hDHFR reveals that the bound water molecules perform structural and functional roles in the complexes.	Water	65-70	dihydrofolate reductase	Homo sapiens	36-41
7707376-4	1995	These water molecules from multiple hydrogen bonds bridging loops and/or secondary structural elements in crystal structures of hDHFR and so stabilize the tertiary fold of the enzyme.	Water	6-11	dihydrofolate reductase	Homo sapiens	128-133
1424295-9	1992	After a water load, the excretion of endogenous EGF was, on the contrary, inversely related to urine volume.	Water	8-13	epidermal growth factor	Homo sapiens	48-51
24420495-6	2014	Owing to web-like structure, high porosity, and high surface reactivity, the NCF aerogels exhibited high mechanical flexibility and ductility, and excellent properties for water uptake, removal of dye pollutants, and the use as thermal insulation materials.	Water	172-177	neutrophil cytosolic factor 4	Homo sapiens	77-80
1431688-1	1992	The infusion of low doses of epidermal growth factor (EGF) into lactating ewes stimulates water intake and urine volume.	Water	90-95	epidermal growth factor	Homo sapiens	29-52
1431688-1	1992	The infusion of low doses of epidermal growth factor (EGF) into lactating ewes stimulates water intake and urine volume.	Water	90-95	epidermal growth factor	Homo sapiens	54-57
7707376-8	1995	Differences in the binding of WatE in the binary and ternary complexes are important for understanding the mechanism of DHFR, since this water molecule is believed to be involved in substrate protonation.	Water	137-142	dihydrofolate reductase	Homo sapiens	120-124
25756669-6	2014	We establish that the physicochemical parameters critical for DPP4 inhibitory activity are: hydrophobicity described by the logarithm of the octanol/water partition coefficient, counts of rotatable bonds, hydrogen bond donor and acceptor atoms, and topological polar surface area.	Water	149-154	dipeptidyl peptidase 4	Homo sapiens	62-66
7533956-8	1995	Additionally, jejunal glucose absorption and water absorption were significantly improved in both IGF-I groups when compared with their respective vehicle controls.	Water	45-50	insulin-like growth factor 1	Rattus norvegicus	98-103
7534405-3	1995	ADH modulates apical membrane water permeability by the insertion and removal of vesicles containing aquaporin collecting duct water channel protein (now termed AQP-2).	Water	30-35	aquaporin 2	Rattus norvegicus	161-166
1329987-1	1992	Human thrombomodulin (TM) was for the first time immobilized on glass beads by the reaction between the carboxyl group of TM and the amino group of glass beads using water-soluble carbodiimide.	Water	166-171	thrombomodulin	Homo sapiens	6-20
1329987-1	1992	Human thrombomodulin (TM) was for the first time immobilized on glass beads by the reaction between the carboxyl group of TM and the amino group of glass beads using water-soluble carbodiimide.	Water	166-171	thrombomodulin	Homo sapiens	22-24
1400063-0	1992	ACE inhibition facilitates sodium and water excretion during PEEP in conscious volume-expanded dogs.	Water	38-43	angiotensin I converting enzyme	Canis lupus familiaris	0-3
25024866-1	2014	Cu-Ni(OH)2/N-GR/Nafion/GCE has been prepared by electrodeposition and activation with NaOH.	Water	6-10	aminomethyltransferase	Homo sapiens	23-26
1639774-14	1992	Our results show that cRNA from 4F2 stimulates the uptake of dibasic and neutral amino acids into oocytes at levels up to 3-fold higher than for water-injected control oocytes.	Water	145-150	solute carrier family 3 (amino acid transporter heavy chain), member 2 L homeolog	Xenopus laevis	32-35
7780191-0	1995	Tritium labelling of amino sugars at C-2 by alkaline epimerization in tritiated water.	Water	80-85	complement C2	Homo sapiens	37-40
24697179-5	2014	In particular, when dextran sulphate was added as ion-pairing agent, formed Fab:DS HIP complexes were least soluble in water.	Water	119-124	FA complementation group B	Homo sapiens	76-79
1321591-7	1992	Using 17O-enriched water, we show conclusively that nucleophilic addition of water occurs at the nitrone carbon (or C-2 position) of DMPO in the presence of either Fe or Cu ions.	Water	19-24	complement C2	Homo sapiens	116-119
1321591-7	1992	Using 17O-enriched water, we show conclusively that nucleophilic addition of water occurs at the nitrone carbon (or C-2 position) of DMPO in the presence of either Fe or Cu ions.	Water	77-82	complement C2	Homo sapiens	116-119
7819219-0	1995	Water requirements in monomer folding and dimerization of triosephosphate isomerase in reverse micelles.	Water	0-5	triosephosphate isomerase	Oryctolagus cuniculus	58-83
24277824-5	2013	For the surface-stabilized catalyst, greatly enhanced rates of water oxidation are observed upon addition of buffer bases -H2PO(-)(4)/HPO(2-)(4), B(OH)3/B(OH)2 O-, HPO(2-)4 /PO(3-)(4) - and with a pathway identified in which O-atom transfer to OH(-) occurs with a rate constant increase of 10(6) compared to water oxidation in acid.	Water	63-68	growth factor, augmenter of liver regeneration	Homo sapiens	164-172
7819219-3	1995	TPI denatured with guanidine hydrochloride undergoes reactivation in reverse micelles formed with n-octane, hexanol, cetyltrimethylammonium bromide, and water.	Water	153-158	triosephosphate isomerase	Oryctolagus cuniculus	0-3
7819219-4	1995	Reactivation of around 80% is observed at TPI concentrations of about 2 micrograms/mL of reverse micelles and water concentrations above 4.0%.	Water	110-115	triosephosphate isomerase	Oryctolagus cuniculus	42-45
7819219-6	1995	If denatured TPI is incubated for a few seconds in reverse micelles with 5.0% water (or higher) followed by incubation in 3.0% water, reactivation is between 35% and 50%.	Water	78-83	triosephosphate isomerase	Oryctolagus cuniculus	13-16
7819219-6	1995	If denatured TPI is incubated for a few seconds in reverse micelles with 5.0% water (or higher) followed by incubation in 3.0% water, reactivation is between 35% and 50%.	Water	127-132	triosephosphate isomerase	Oryctolagus cuniculus	13-16
7819219-7	1995	That is, a brief exposure of denatured TPI to reverse micelles with a relatively high water concentration yielded a significant amount of structures competent for formation of catalytically active dimers.	Water	86-91	triosephosphate isomerase	Oryctolagus cuniculus	39-42
17832834-2	1992	The effect of warming the surface layer of the ocean and there by expanding the water column has been to raise sea level by 0.9 +/- 0.2 millimeter per year.	Water	80-85	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	111-114
24154696-1	2013	Binding of vasopressin to its type 2 receptor in renal collecting ducts induces cAMP signaling, transcription and translocation of aquaporin (AQP)2 water channels to the plasma membrane, and water reabsorption from the prourine.	Water	148-153	aquaporin 2	Homo sapiens	142-147
1514103-6	1992	A water mass budget for the surface layer of the Arctic Ocean, the most biologically active part of that sea, is constructed to examine the mass budget for one of the major persistent organochlorine compound groups found in remote regions, hexachlorocyclohexanes (HCH), one isomer of which is lindane.	Water	2-7	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	105-108
1457864-4	1992	RGD ALB was prepared via a coupling reaction of albumin with pentapeptide (GRGDS; Gly-RGD-Ser) by water soluble carbodiimide.	Water	98-103	albumin	Bos taurus	4-7
7528271-2	1995	PATIENTS AND METHODS: Twenty-five patients with small-cell lung cancer (SCLC) were treated with six cycles of ifosfamide, carboplatin, and etoposide (ICE) with granulocyte colony-stimulating factor (G-CSF) 300 micrograms/d subcutaneously (SC) on days 4 to 15.	Water	150-153	colony stimulating factor 3	Homo sapiens	160-197
8926641-3	1995	LEW, WKAH, (LEW x WKAH)F1, and (LEW x WKAH)F2 rats were examined to determine the incidence and severity of EAU induced by immunization with bovine S-antigen (S-Ag).	Water	108-111	S-antigen visual arrestin	Rattus norvegicus	148-157
8926641-7	1995	These findings suggest that only one non-MHC gene controls the susceptibility to S-Ag-induced EAU in rats.	Water	94-97	S-antigen visual arrestin	Rattus norvegicus	81-85
26592287-0	2013	SPAM: A Simple Approach for Profiling Bound Water Molecules.	Water	44-49	eyes shut homolog	Homo sapiens	0-4
26592287-2	2013	The method, which we call "SPAM" (maps spelled in reverse), utilizes explicit solvent molecular dynamics (MD) simulations to capture discrete hydration sites at the water-protein interface and computes a local free energy measure from the distribution of interaction energies between water and the environment at a specific site.	Water	165-170	eyes shut homolog	Homo sapiens	27-31
1625447-6	1992	EXPERIMENTAL DESIGN: Lewis rats immunized with S-antigen were used to produce EAU.	Water	78-81	S-antigen visual arrestin	Rattus norvegicus	47-56
26592287-2	2013	The method, which we call "SPAM" (maps spelled in reverse), utilizes explicit solvent molecular dynamics (MD) simulations to capture discrete hydration sites at the water-protein interface and computes a local free energy measure from the distribution of interaction energies between water and the environment at a specific site.	Water	284-289	eyes shut homolog	Homo sapiens	27-31
24224524-2	2013	We also demonstrate the effects of varying the concentration of the SFN sol on the water and hexadecane repellency and on the transparency of the coated glass substrates.	Water	83-88	RNA exonuclease 2	Homo sapiens	68-71
1615323-4	1992	The theory and experiment suggest that the dominant factor in markedly reducing the rate of conformational changes in myoglobin at low temperatures (less than 200 K) is the very high viscosity (greater than 10(7) centipoise) of the glycerol-water solvent.	Water	241-246	myoglobin	Homo sapiens	118-127
7811688-1	1994	The 1H-NMR chemical shift assignments for the oxidized A-chain of bovine insulin have been determined in aqueous and 30% trifluoroethanol/water solutions.	Water	138-143	insulin	Bos taurus	73-80
24063264-3	2013	Each lactoferrin molecule was averagely attached to 4 to 6 deferasirox molecules resulting in water-soluble conjugated nanostructures which were purified and characterized.	Water	94-99	lactotransferrin	Rattus norvegicus	5-16
10319157-1	1994	The water soluble long-chain crosslinker, sulfo-succinimidyl-6-[3"-(2-pyridyldithio)-propionamido]hexanoate (S-LC-SPDP) was used to prepare ricin A chain (RTA) immunotoxins constructed with whole IgG and Fab fragments of the anti-common acute lymphoblastic leukemia antigen (CALLA) monoclonal antibody.	Water	4-9	MAS related GPR family member F	Homo sapiens	155-158
10319157-1	1994	The water soluble long-chain crosslinker, sulfo-succinimidyl-6-[3"-(2-pyridyldithio)-propionamido]hexanoate (S-LC-SPDP) was used to prepare ricin A chain (RTA) immunotoxins constructed with whole IgG and Fab fragments of the anti-common acute lymphoblastic leukemia antigen (CALLA) monoclonal antibody.	Water	4-9	FA complementation group B	Homo sapiens	204-207
1375008-7	1992	G-CSF-treated animals showed attenuated responses in peripheral leukopenia, excess lung water, and albumin leakage in comparison with the endotoxin-alone group.	Water	88-93	colony stimulating factor 3	Homo sapiens	0-5
24056000-0	2013	Model simulation of inflow water to the Baltic Sea based on 129I.	Water	27-32	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	47-50
1592012-5	1992	Intracellular concentration of K+, Na+, and Cl- ([K+]1, [Na+]1, and [Cl-]1) derived from the flame photometric and from the radioisotope uptake data of DBA astrocytes were 120.4 +/- 8.5, 25.9 +/- 3.2, and 26.8 +/- 1.8 mM/L cell H2O, respectively.	Water	228-231	CDC-like kinase 1	Mus musculus	44-54
7874266-3	1994	In this study, the effects of water-immersion stress and the administration of 5-HT on the expression of a 60-kDa heat shock protein (HSP60) in rat colonic mucosa were investigated.	Water	30-35	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	134-139
7874266-5	1994	Water-immersion stress and the administration of 5-HT induced synthesis of HSP60 in rat colonic mucosa.	Water	0-5	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	75-80
7874266-7	1994	Our results suggest that the induction of HSP60 in rat colonic mucosa by water-immersion stress may be associated with gastrointestinal motility mediated by 5-HT, especially via 5-HT3 receptors.	Water	73-78	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	42-47
24056000-4	2013	We present here a model to estimate water inflow from the North Sea to the Baltic Sea by utilizing 129I as a tracer.	Water	36-41	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	64-67
24056000-4	2013	We present here a model to estimate water inflow from the North Sea to the Baltic Sea by utilizing 129I as a tracer.	Water	36-41	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	82-85
24056000-6	2013	Despite limited time series data on 129I, the model presented here demonstrates a new management tool for the Baltic Sea to calculate inflow water compared to conventional methods (such as salinity, temperature and hydrographic models).	Water	141-146	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	117-120
18600901-3	1992	In this study, the polyoxazoline family of water-soluble polymers was used to synthesize adducts containing a synthetic peptide recognized by a monoclonal antibody (MAb) directed against human protein C (hPC).	Water	43-48	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	193-202
24076009-7	2013	Structural alignment of AtGLYR1 with beta-HAD family members provided support for the essentiality of Lys170, Phe173, Asp239, Ser121, Asn174 and Thr95 in the active site and preliminary support for an acid/base catalytic mechanism involving Lys170 as the general acid and a conserved active-site water molecule.	Water	296-301	glyoxylate reductase 1	Arabidopsis thaliana	24-31
18407239-3	1994	The genes involved encode proteins that reside at both ends of the cellular vasopressin signaling cascade, namely the vasopressin V(2) receptor and the aquaporin-2 water channel.	Water	164-169	aquaporin 2	Homo sapiens	152-163
18407239-4	1994	Analysis of naturally occurring mutations in the V(2) receptor and the aquaporin-2 water channel will facilitate the study of structure-function correlates of both proteins, which will lead to substantial progress in elucidating the cellular mechanisms involved in the antidiuretic effect of vasopressin.	Water	83-88	aquaporin 2	Homo sapiens	71-82
1551892-6	1992	13C NMR studies using 18O-labeled L-aspartic acid demonstrate that glycoasparaginase catalyzes an oxygen exchange between water and the carboxyl group at C-4 of L-aspartic acid.	Water	122-127	complement C4A (Rodgers blood group)	Homo sapiens	154-157
7527226-4	1994	The back-extraction of cytochrome b5 to a fresh aqueous phase was decreased by factors that reduced the size of the water pool of the organic phase, such as high salt concentrations (1-2 mol dm-3 NaCl) and low temperatures (4 degrees C), probably because of an increase in a favourable interaction of this protein with the surfactant at closer distances.	Water	116-121	cytochrome b5 type A	Homo sapiens	23-36
23806664-6	2013	The reason for the larger efficiency of the combined trap is that it captures simultaneously the host-seeking female and the water-seeking male and female tabanids.	Water	125-130	acid phosphatase 5, tartrate resistant	Bos taurus	53-57
1367974-0	1992	Fate in water of a recombinant Escherichia coli K-12 strain used in the commercial production of bovine somatotropin.	Water	8-13	somatotropin	Bos taurus	104-116
1819701-1	1991	Approximately 75% of the PAF present in saliva is recovered on extraction of whole saliva (0.8 vol) with chloroform/methanol/water (2:2:1, v/v/v).	Water	125-130	PCNA clamp associated factor	Homo sapiens	25-28
24248912-8	2013	The all-atom 12 ns molecular dynamics simulation of Patt1 model with TIP3P water model and counterions was conducted.	Water	75-80	N-alpha-acetyltransferase 40, NatD catalytic subunit	Homo sapiens	52-57
7703854-0	1994	Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: absence of the conserved structural water.	Water	120-125	LOC104974671	Bos taurus	66-82
7703854-6	1994	Although the geometry of the catalytic triad in the PLA2 mutant remains the same as in the WT, we were surprised that the conserved structural water, linking the catalytic site with the ammonium group of Ala-1 of the interfacial site, was ejected by the proximity of the NH2 group of Asn-99.	Water	143-148	LOC104974671	Bos taurus	52-56
1659972-1	1991	Known functions of the RPE include glucose, water and retinoid transports; an ion transport mechanism utilizing a Na(+)-K(+)-ATPase pump located in the apical membrane has been proposed.	Water	44-49	ribulose-phosphate 3-epimerase	Bos taurus	23-26
24012239-2	2013	A set of phenol-degrading strains of a collection of bacteria isolated from Baltic Sea surface water was screened for the presence of two key catabolic genes coding for phenol hydroxylases and catechol 2,3-dioxygenases.	Water	95-100	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	83-86
7929845-6	1994	We propose that IL-2 treatment enhances protection from EAU at least in part by stimulating production of antiinflammatory cytokines by regulatory cells in Payer"s Patches.	Water	56-59	interleukin 2	Mus musculus	16-20
24113906-0	2013	An OFF-ON chemosensor for biological and environmental applications: sensing Cd2+ in water using catanionic vesicles and in living cells.	Water	85-90	CD2 molecule	Homo sapiens	77-80
7835893-1	1994	Human microsomal epoxide hydrolase (mEH) is a xenobiotic-metabolizing enzyme that detoxifies reactive epoxides to more water soluble dihydrodiol compounds.	Water	119-124	epoxide hydrolase 1	Homo sapiens	6-34
1752629-8	1991	Adsorption of BSA, beta-lactoglobulin, gelatin, myosin and lysozyme is negative on Sephadex surface due to the excess adsorption of water by Sephadex.	Water	132-137	myosin heavy chain 14	Homo sapiens	48-54
24278223-6	2013	We also observed that APPswe/PS1dE9 mice lesioned with 5,7-DHT were impaired in the Morris water maze test, supporting a synergistic effect of the serotonergic denervation and the presence of APP/PS1 transgenes on learning and memory impairment.	Water	91-96	presenilin 1	Mus musculus	29-32
1713710-1	1991	The 2.05 angstrom (A) resolution crystal structure of a dodecasaccharide-Fab complex revealed an unusual carbohydrate recognition site, defined by aromatic amino acids and a structured water molecule, rather than the carboxylic acid and amide side chains and a structured water molecule, rather than the carboxylic acid and amide side chains that are features of transport and other carbohydrate binding proteins.	Water	185-190	FA complementation group B	Homo sapiens	73-76
1713710-1	1991	The 2.05 angstrom (A) resolution crystal structure of a dodecasaccharide-Fab complex revealed an unusual carbohydrate recognition site, defined by aromatic amino acids and a structured water molecule, rather than the carboxylic acid and amide side chains and a structured water molecule, rather than the carboxylic acid and amide side chains that are features of transport and other carbohydrate binding proteins.	Water	272-277	FA complementation group B	Homo sapiens	73-76
8051116-4	1994	Under isosmotic conditions (290 mosmol/kg H2O), the Na+/H+ exchange rate increased sigmoidally over the pHi range 7.8 to 6.5 (Hill coefficient = 2.1), consistent with cooperative activation of the exchanger by internal H+.	Water	42-45	glucose-6-phosphate isomerase	Rattus norvegicus	104-107
24253616-5	2013	Strikingly, the neuroprotective effect of H2 water was abolished by either administration of the ghrelin receptor-antagonist, D-Lys(3) GHRP-6, or atenolol.	Water	45-50	growth hormone secretagogue receptor	Mus musculus	97-113
8051116-6	1994	Hyperosmolality (590 mosmol/kg H2O) inhibited Na+/H+ exchange by at least 35% at all pHi values studied and induced pHi dependence of the exchanger between 6.5 and 7.2.	Water	31-34	glucose-6-phosphate isomerase	Rattus norvegicus	85-88
8051116-6	1994	Hyperosmolality (590 mosmol/kg H2O) inhibited Na+/H+ exchange by at least 35% at all pHi values studied and induced pHi dependence of the exchanger between 6.5 and 7.2.	Water	31-34	glucose-6-phosphate isomerase	Rattus norvegicus	116-119
1856855-0	1991	Determination of the positions of bound water molecules in the solution structure of reduced human thioredoxin by heteronuclear three-dimensional nuclear magnetic resonance spectroscopy.	Water	40-45	thioredoxin	Homo sapiens	99-110
1856855-1	1991	The presence of bound water molecules in the solution structure of reduced human thioredoxin has been investigated using three-dimensional 1H rotating frame Overhauser 1H-15N multiple quantum coherence spectroscopy.	Water	22-27	thioredoxin	Homo sapiens	81-92
1856855-3	1991	Examination of the high-resolution solution structure of reduced human thioredoxin reveals that these results are best accounted for by four bound water molecules.	Water	147-152	thioredoxin	Homo sapiens	71-82
1856855-4	1991	Subsequent simulated annealing calculations carried out on the basis of interproton distance and hydrogen bonding restraints to the bound water molecules, supplemented by the original set of experimental restraints used in the calculation of the three-dimensional structure of human thioredoxin, permit a more precise localization of the bound water positions.	Water	344-349	thioredoxin	Homo sapiens	283-294
1856855-5	1991	Potential hydrogen bonds to these water molecules are described and a comparison is made to corresponding bound water molecules in the crystal structure of oxidized Escherichia coli thioredoxin.	Water	34-39	thioredoxin	Homo sapiens	182-193
1856855-5	1991	Potential hydrogen bonds to these water molecules are described and a comparison is made to corresponding bound water molecules in the crystal structure of oxidized Escherichia coli thioredoxin.	Water	112-117	thioredoxin	Homo sapiens	182-193
7982533-0	1994	Evaluation of exposure to water aerosol or air by nose-only or whole-body inhalation procedures for CD-1 mice in developmental toxicity studies.	Water	26-31	CD1 antigen complex	Mus musculus	100-104
23813972-0	2013	Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases.	Water	14-19	solute carrier family 4 member 11	Homo sapiens	33-40
23813972-4	2013	Here we identified SLC4A11, a member of the solute carrier family 4 of bicarbonate transporters, as an unexpected addition to known transmembrane water movement facilitators.	Water	146-151	solute carrier family 4 member 11	Homo sapiens	19-26
8003467-6	1994	We propose instead that the N5 protonated form of H2folate is stabilized directly at the active site in the DHFR/NADPH/H2folate complex by specific interactions that form only in the ternary complex, involving perhaps a bound water molecule, the carboxamide moiety of the coenzyme, and/or the local electrostatic field of the enzyme molecule, to which an important contribution may be made by Asp-27.	Water	226-231	Dihydrofolate reductase	Escherichia coli	108-112
1830460-0	1991	Renal, hormonal, and fluid shift responses to ANP during head-out water immersion in awake dogs.	Water	66-71	natriuretic peptide A	Canis lupus familiaris	46-49
1830460-1	1991	Renal responses to low doses of atrial natriuretic peptide (ANP) may be potentiated during water immersion-induced central hypervolemia.	Water	91-96	natriuretic peptide A	Canis lupus familiaris	32-58
1830460-1	1991	Renal responses to low doses of atrial natriuretic peptide (ANP) may be potentiated during water immersion-induced central hypervolemia.	Water	91-96	natriuretic peptide A	Canis lupus familiaris	60-63
23813972-7	2013	SLC4A11-mediated water movement was: (i) similar to some AQPs in rate; (ii) uncoupled from solute-flux; (iii) inhibited by stilbene disulfonates (classical SLC4 inhibitors); (iv) inactivated in one CHED2 mutant (R125H).	Water	17-22	solute carrier family 4 member 11	Homo sapiens	0-7
23813972-8	2013	Localization of AQP1 and SLC4A11 in human and murine corneal (apical and basolateral, respectively) suggests a cooperative role in mediating trans-endothelial water reabsorption.	Water	159-164	solute carrier family 4 member 11	Homo sapiens	25-32
23813972-10	2013	Observed water-flux through SLC4A11 extends the repertoire of known water movement pathways and call for a re-examination of explanations for water movement in human tissues.	Water	9-14	solute carrier family 4 member 11	Homo sapiens	28-35
24032448-4	2013	Repeated (514) high-throughput measurements of the international isotopic reference water standard Greenland Ice Sheet Precipitation (GISP) demonstrate the precision and accuracy of OA-ICOS: delta(18)OVSMOW-SLAP = -24.74 +- 0.07% (1sigma) and delta(17)OVSMOW-SLAP = -13.12 +- 0.05% (1sigma).	Water	84-89	regenerating family member 4	Homo sapiens	134-138
1940639-7	1991	SPT activity also increased after barrier disruption, peaking at 6 h (150%) (P less than 0.05), and returning towards normal by 24 h. Artificial restoration of the barrier with a water vapor-impermeable membrane prevented the increases in both [3H]H2O incorporation into sphingolipids and enzyme activity.	Water	179-184	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-3
1940639-7	1991	SPT activity also increased after barrier disruption, peaking at 6 h (150%) (P less than 0.05), and returning towards normal by 24 h. Artificial restoration of the barrier with a water vapor-impermeable membrane prevented the increases in both [3H]H2O incorporation into sphingolipids and enzyme activity.	Water	248-251	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-3
1946145-2	1991	AMPH, but not NPE, significantly increased water intake.	Water	43-48	amphiphysin	Rattus norvegicus	0-4
8025810-2	1994	In in vivo applications, T1 and B1 inhomogeneity within the sample may cause spatially inhomogeneous water suppression.	Water	101-106	CD5 molecule	Homo sapiens	25-34
8025810-3	1994	An improved water-suppression technique called WET (water suppression enhanced through T1 effects), developed from a Bloch equation analysis of the longitudinal magnetization over the T1 and B1 ranges of interest, achieves T1- and B1-insensitive suppression with four RF pulses, each having a numerically optimized flip angle.	Water	12-17	CD5 molecule	Homo sapiens	184-193
8025810-3	1994	An improved water-suppression technique called WET (water suppression enhanced through T1 effects), developed from a Bloch equation analysis of the longitudinal magnetization over the T1 and B1 ranges of interest, achieves T1- and B1-insensitive suppression with four RF pulses, each having a numerically optimized flip angle.	Water	52-57	CD5 molecule	Homo sapiens	184-193
24014685-3	2013	Analysis of BrdU incorporation during long-term feeding and during chasing (delabeling) following replacement of BrdU-water with normal water shows that the CD45(neg)CD31(neg)Sca-1(pos) lung mesenchymal stromal cell compartment turns over at a rate of ~2.26% per day with a time to half-cycled of 44 days, an estimated cell proliferation rate of 0.004/day, and a cell death rate of 0.018/day.	Water	118-123	protein tyrosine phosphatase, receptor type, C	Mus musculus	157-161
7512826-0	1994	Interaction of recombinant granulocyte colony stimulating factor with lipid membranes: enhanced stability of a water-soluble protein after membrane insertion.	Water	111-116	colony stimulating factor 3	Homo sapiens	27-64
1819046-1	1991	Fast atom bombardment mass spectrometry (FAB) was used to determine the glycation sites of lysozyme in a restricted water environment.	Water	116-121	FA complementation group B	Homo sapiens	41-44
24014685-3	2013	Analysis of BrdU incorporation during long-term feeding and during chasing (delabeling) following replacement of BrdU-water with normal water shows that the CD45(neg)CD31(neg)Sca-1(pos) lung mesenchymal stromal cell compartment turns over at a rate of ~2.26% per day with a time to half-cycled of 44 days, an estimated cell proliferation rate of 0.004/day, and a cell death rate of 0.018/day.	Water	136-141	protein tyrosine phosphatase, receptor type, C	Mus musculus	157-161
1866378-2	1991	The use of a 30/70 mixture of trichlorofluoromethane (P11) and dichlorodifluoromethane (P12) resulted in the formation of stable, isotropic systems containing 0.5-2.0% (w/v) SPC and solubilized water; R (moles water/moles SPC), 0.9 to 4.28.	Water	210-215	endonuclease, poly(U) specific	Homo sapiens	54-57
24070451-10	2013	The results show that IFST alone can be used to reliably predict the observed displacement of water molecules in Hsp90.	Water	94-99	heat shock protein 90 alpha family class A member 1	Homo sapiens	113-118
1866378-3	1991	In systems containing less than 30% P11, phase separation became apparent, particularly at higher water and surfactant concentrations.	Water	98-103	endonuclease, poly(U) specific	Homo sapiens	36-39
24013296-1	2013	A cobalt complex with a tripyridine-diamine pentadentate ligand was found to be a highly active catalyst for electrochemical H2 production from neutral water, with an activity of 860 mol H2 (mol cat)(-1) h(-1) (cm(2) Hg)(-1) over 60 h CPE experiment at -1.25 V in a pH 7 phosphate buffer solution, without considerable deactivation.	Water	152-157	carboxypeptidase E	Homo sapiens	235-238
24242175-3	1991	With a mobile phase consisting of methanol/water/triethanolamine (80:20:0.5, v/v/w), flow injection frit-FAB analysis of oligonucleotides showed lower limits of detection compared to standard probe FAB mass spectrometry.	Water	43-48	FA complementation group B	Homo sapiens	105-108
7511600-0	1994	Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers.	Water	44-49	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	37-43
7511600-1	1994	CHIP28 is a major water transporting protein in erythrocytes and kidney which forms tetramers in membranes (Verbavatz, J. M., Brown, D., Sabolic, I., Valenti, G., Ausiello, D. A., Van Hoek, A. N., Ma, T., and Verkman, A. S. (1993) J.	Water	18-23	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	0-6
7511600-7	1994	CHIP28 homo- and heterodimers were targeted to the oocyte plasma membrane and functioned as water channels.	Water	92-97	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	0-6
7511600-12	1994	These results indicate that despite their assembly in tetramers, monomeric CHIP28 subunits function independently as water channels.	Water	117-122	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	75-81
24242175-3	1991	With a mobile phase consisting of methanol/water/triethanolamine (80:20:0.5, v/v/w), flow injection frit-FAB analysis of oligonucleotides showed lower limits of detection compared to standard probe FAB mass spectrometry.	Water	43-48	FA complementation group B	Homo sapiens	198-201
24242175-8	1991	Finally, frit-FAB liquid chromatography mass spectrometry was demonstrated by separating mixtures of oligonucleotides on a beta -cyclodextrin high-performance liquid chromatography column with a mobile phase containing methanol, water, and triethanolamine.	Water	229-234	FA complementation group B	Homo sapiens	14-17
24107005-2	2013	We report the ultraviolet (UV) and infrared (IR) spectra of size-selected and jet-cooled 9H-2AP (H2O)n clusters with n = 2 and 3.	Water	97-100	H2A clustered histone 11	Homo sapiens	90-95
1869900-1	1991	A theoretical conformational study was performed on leu-enkephalin in its zwitterionic form, both in vacuo and in the presence of a number, n, of up to 13 water molecules saturating its first hydration shell.	Water	155-160	prodynorphin	Homo sapiens	52-66
7512605-7	1994	The conformation of myoglobin is as stable in water as in trifluoroethanol, and therefore acted as a negative control.	Water	46-51	myoglobin	Homo sapiens	20-29
23986122-0	2013	Single-step noninjection synthesis of highly luminescent water soluble Cu+ doped CdS quantum dots: application as bio-imaging agents.	Water	57-62	CDP-diacylglycerol synthase 1	Homo sapiens	81-84
7509789-1	1994	Two mercurial-inhibitable water-transporting proteins have been identified: CHIP28, an erythrocyte water channel also expressed in kidney tubules and selected extrarenal epithelia, and WCH-CD, a kidney collecting duct water channel.	Water	26-31	aquaporin 2	Rattus norvegicus	185-191
7509789-2	1994	In searching for a protein responsible for the high transcellular water permeability in lung alveolus, we cloned a 32-kDa water channel (mercurial-insensitive water channel (MIWC)) from a rat lung cDNA library with several novel features.	Water	66-71	aquaporin 4	Rattus norvegicus	137-172
7509789-2	1994	In searching for a protein responsible for the high transcellular water permeability in lung alveolus, we cloned a 32-kDa water channel (mercurial-insensitive water channel (MIWC)) from a rat lung cDNA library with several novel features.	Water	66-71	aquaporin 4	Rattus norvegicus	174-178
7509789-2	1994	In searching for a protein responsible for the high transcellular water permeability in lung alveolus, we cloned a 32-kDa water channel (mercurial-insensitive water channel (MIWC)) from a rat lung cDNA library with several novel features.	Water	122-127	aquaporin 4	Rattus norvegicus	137-172
1999479-8	1991	In cells labelled with [3H]choline, the water soluble phosphatidylcholine hydrolysis products, phosphorylcholine and choline, were increased 2-fold within 5 minutes of addition of EGF.	Water	40-45	epidermal growth factor	Homo sapiens	180-183
1825155-9	1991	We conclude that transgenic mice overexpressing ANF can maintain normal excretion of salt and water, possibly via ANF-induced reduction of renal perfusion pressure.	Water	94-99	natriuretic peptide type A	Mus musculus	48-51
1825159-0	1991	Effects of atrial natriuretic peptide on water and NaCl absorption across the intestine.	Water	41-46	natriuretic peptide A	Canis lupus familiaris	11-37
7509789-2	1994	In searching for a protein responsible for the high transcellular water permeability in lung alveolus, we cloned a 32-kDa water channel (mercurial-insensitive water channel (MIWC)) from a rat lung cDNA library with several novel features.	Water	122-127	aquaporin 4	Rattus norvegicus	174-178
7509789-3	1994	Water permeability was strongly increased in Xenopus oocytes expressing MIWC in a mercurial-insensitive manner, in contrast to known water channels.	Water	0-5	aquaporin 4	Rattus norvegicus	72-76
1825159-3	1991	Therefore, the purpose of the present study was to investigate the effects of ANP on water and NaCl absorption across the intestine.	Water	85-90	natriuretic peptide A	Canis lupus familiaris	78-81
1825159-8	1991	Finally, we studied the effects of ANP on intestinal absorption of water and NaCl.	Water	67-72	natriuretic peptide A	Canis lupus familiaris	35-38
7509789-6	1994	The MIWC water channel may participate in the urinary concentrating mechanism, the absorption of cerebrospinal fluid, and other physiological processes.	Water	9-14	aquaporin 4	Rattus norvegicus	4-8
23831422-6	2013	In human subjects, two-alternative forced choice (2-AFC) tests, triangle tests and sensory profiling showed that non fatty acid agonists of GPR40 dissolved in water are detected in sip and spit tests and elicit a taste similar to that of linoleic acid, whereas 2-AFC tests showed that two agonists of GPR120 in water are not perceived fattier than water alone.	Water	159-164	free fatty acid receptor 1	Homo sapiens	140-145
1825159-9	1991	ANP suppressed net absorption of water by 61%, Na+ by 43%, and Cl- by 42% across the jejunum but not the ileum.	Water	33-38	natriuretic peptide A	Canis lupus familiaris	0-3
1825159-10	1991	These results suggest that ANP modulates water and NaCl homeostasis across the jejunum but not across the ileum.	Water	41-46	natriuretic peptide A	Canis lupus familiaris	27-30
8301251-3	1994	The actin-membrane linkage would restrain cell swelling in the event of the influx of water.	Water	86-91	actin	Oryctolagus cuniculus	4-9
23831422-6	2013	In human subjects, two-alternative forced choice (2-AFC) tests, triangle tests and sensory profiling showed that non fatty acid agonists of GPR40 dissolved in water are detected in sip and spit tests and elicit a taste similar to that of linoleic acid, whereas 2-AFC tests showed that two agonists of GPR120 in water are not perceived fattier than water alone.	Water	311-316	free fatty acid receptor 1	Homo sapiens	140-145
23831422-6	2013	In human subjects, two-alternative forced choice (2-AFC) tests, triangle tests and sensory profiling showed that non fatty acid agonists of GPR40 dissolved in water are detected in sip and spit tests and elicit a taste similar to that of linoleic acid, whereas 2-AFC tests showed that two agonists of GPR120 in water are not perceived fattier than water alone.	Water	311-316	free fatty acid receptor 1	Homo sapiens	140-145
7516561-9	1994	In contrast, when MWH was performed in water, the specific intensity of PCNA expression was not increased because MWH not only enhanced the intensity of the antigen staining but also increased the background staining.	Water	39-44	proliferating cell nuclear antigen	Homo sapiens	72-76
1723632-7	1991	These results indicate that the carboxy-terminus of S-antigen plays a predominant role in the pathogenesis of EAU.	Water	110-113	S-antigen visual arrestin	Rattus norvegicus	52-61
24060138-3	2013	Mass spectrometric (MS) analyses of the reactions of water in air with 1 and 2 show formation of the Zr monomer Zr( O)[(i)PrNC(NMe2)N(i)Pr]2 (10), oxo dimers 4 and 5, and dihydroxyl complexes M(OH)2[(i)PrNC(NMe2)N(i)Pr]2 (M = Zr, 11; Hf, 12).	Water	53-58	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	127-131
8138683-9	1994	Water content of cerebral tissue in P-RCP were significantly lower than those of NP-RCP.	Water	0-5	long-wave-sensitive opsin 1	Canis lupus familiaris	38-41
1769200-6	1991	wt water-soluble substrates with fucose in alpha 1-2 linkage to galactose.	Water	3-8	adrenoceptor alpha 1D	Homo sapiens	43-50
24060138-3	2013	Mass spectrometric (MS) analyses of the reactions of water in air with 1 and 2 show formation of the Zr monomer Zr( O)[(i)PrNC(NMe2)N(i)Pr]2 (10), oxo dimers 4 and 5, and dihydroxyl complexes M(OH)2[(i)PrNC(NMe2)N(i)Pr]2 (M = Zr, 11; Hf, 12).	Water	53-58	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	207-211
23998392-1	2013	NMR experiments have shown that water molecules in the crystal of the protein Crh are still mobile at temperatures well below 273 K. In order to investigate this water anomaly, a molecular dynamics (MD) simulation study of crystalline Crh was carried out to determine the mobility of water in this crystal.	Water	32-37	corticotropin releasing hormone	Homo sapiens	78-81
22061970-5	1991	Percent water loss was greater for PSE extracts than for controls at the same protein concentration.	Water	8-13	PSE	Sus scrofa	35-38
7994366-2	1994	In myoglobin, His-E7 inhibits CO binding by requiring displacement of distal pocket water.	Water	84-89	myoglobin	Homo sapiens	3-12
7512890-0	1994	Assignment of the human gene for the water channel of renal collecting duct Aquaporin 2 (AQP2) to chromosome 12 region q12--&gt;q13.	Water	37-42	aquaporin 2	Homo sapiens	76-87
1805512-3	1991	The ionization constants of primaquine in 50% (v/v) ethanol in water determined at 25 degrees C in the ionic strength range of 5 x 10(-3)-5 x 10(-2) mol/L are: Ka1 = (3.84 +/- 2.35) x 10(-2) (attributed to the secondary ammonium group of primaquine); Ka2 = (1.50 +/- 1.17) x 10(-8) (attributed to the tertiary ammonium group); Ka3 = (2.07 +/- 0.27) x 10(-10) (attributed to the primary ammonium group).	Water	63-68	glutamate ionotropic receptor kainate type subunit 4	Homo sapiens	160-163
23998392-1	2013	NMR experiments have shown that water molecules in the crystal of the protein Crh are still mobile at temperatures well below 273 K. In order to investigate this water anomaly, a molecular dynamics (MD) simulation study of crystalline Crh was carried out to determine the mobility of water in this crystal.	Water	32-37	corticotropin releasing hormone	Homo sapiens	235-238
23998392-1	2013	NMR experiments have shown that water molecules in the crystal of the protein Crh are still mobile at temperatures well below 273 K. In order to investigate this water anomaly, a molecular dynamics (MD) simulation study of crystalline Crh was carried out to determine the mobility of water in this crystal.	Water	162-167	corticotropin releasing hormone	Homo sapiens	78-81
24070273-7	2013	Our tests on a range of different water clusters up to the 16-mer show that for the second-order Moller-Plesset (MP2) method the EMBE truncated at 2-body level reproduces to better than 0.1 mE(h)/monomer the correlation energy from standard methods.	Water	34-39	tryptase pseudogene 1	Homo sapiens	113-116
2125219-3	1990	In contrast, no change was observed in the level of choline and phosphatidic acid whereas the release of water-soluble metabolites in [3H]ethanolamine prelabelled cells exposed to growth hormone was hardly detectable.	Water	105-110	growth hormone	Mus musculus	180-194
7512890-0	1994	Assignment of the human gene for the water channel of renal collecting duct Aquaporin 2 (AQP2) to chromosome 12 region q12--&gt;q13.	Water	37-42	aquaporin 2	Homo sapiens	89-93
7512890-1	1994	The chromosomal localization of the gene encoding Aquaporin 2 (previously called WCH-CD), which acts as a water channel in the collecting tubules of the kidney, was determined.	Water	106-111	aquaporin 2	Homo sapiens	50-61
7512890-1	1994	The chromosomal localization of the gene encoding Aquaporin 2 (previously called WCH-CD), which acts as a water channel in the collecting tubules of the kidney, was determined.	Water	106-111	aquaporin 2	Homo sapiens	81-87
23782236-9	2013	Osmotic activation volumes, determined from the dependence of ki on osmotic pressure, showed that water in the gorge of the D70G mutant is more easily depleted than that in wild-type BChE.	Water	98-103	butyrylcholinesterase	Homo sapiens	183-187
8050398-1	1994	Results are presented for proteins with known three-dimensional structure (lysozyme, myoglobin, ribonuclease), which show that the probability of label incorporation upon bombardment by "hot" tritium atoms may be quantitatively linked with the surface area of the protein accessible to water molecules.	Water	286-291	myoglobin	Homo sapiens	85-94
23842530-1	2013	Aquaporin 6 (AQP6) is unique among mammalian AQPs in being an anion channel with negligible water permeability.	Water	92-97	aquaporin 6	Homo sapiens	0-11
8133480-1	1994	After the ultrasonic tip is introduced into the highly myopic eye and inflow is activated, the anterior chamber deepens, the lens-iris diaphragm is displaced posteriorly, the iris becomes concave, and the pupil dilates from the weight of the water column above the eye.	Water	242-247	TOR signaling pathway regulator	Homo sapiens	21-24
1707128-3	1990	A water-soluble GnRH antagonist was administered iv to castrate male rats (increased endogenous GnRH secretion) and to castrate T-replaced rats in which gonadotropin subunit mRNAs had been increased by prior treatment with exogenous GnRH pulses.	Water	2-7	gonadotropin releasing hormone 1	Rattus norvegicus	16-20
1707128-3	1990	A water-soluble GnRH antagonist was administered iv to castrate male rats (increased endogenous GnRH secretion) and to castrate T-replaced rats in which gonadotropin subunit mRNAs had been increased by prior treatment with exogenous GnRH pulses.	Water	2-7	gonadotropin releasing hormone 1	Rattus norvegicus	96-100
1707128-3	1990	A water-soluble GnRH antagonist was administered iv to castrate male rats (increased endogenous GnRH secretion) and to castrate T-replaced rats in which gonadotropin subunit mRNAs had been increased by prior treatment with exogenous GnRH pulses.	Water	2-7	gonadotropin releasing hormone 1	Rattus norvegicus	96-100
23842530-1	2013	Aquaporin 6 (AQP6) is unique among mammalian AQPs in being an anion channel with negligible water permeability.	Water	92-97	aquaporin 6	Homo sapiens	13-17
23842530-2	2013	However, the point mutation Asn60Gly converts AQP6 from an anion channel into a water channel.	Water	80-85	aquaporin 6	Homo sapiens	46-50
7521504-5	1994	By placing the fiber tip in direct contact with tissue, much larger lesions are created because of more efficient energy transfer resulting in rapid evaporation of tissue under water.	Water	177-182	TOR signaling pathway regulator	Homo sapiens	21-24
2093185-2	1990	Since angiotensin II (AII) is a powerful elicitor of drinking behavior, we investigated the influence of the angiotensin converting enzyme inhibitor, captopril, on the amount of water consumed by the STR/N mouse.	Water	178-183	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	109-138
23842530-5	2013	We found that AQP5-L51R does not exhibit the H2O or CO2 permeability of the wild-type protein but instead has a novel p-chloromercuribenzene sulfonate (pCMBS)-sensitive current.	Water	45-48	aquaporin 5	Homo sapiens	14-18
23951997-5	2013	To contribute to this effort, we here study an optical probe, N-acetylaladanamide (NAAA), in the presence of a POPC lipid bilayer using a multiscale integrated approach to assess the probe structure, dynamics, and optical properties in its membrane-bound status and in water solvent.	Water	269-274	N-acylethanolamine acid amidase	Homo sapiens	62-81
2248964-2	1990	At pH 5.6, the optimal pH of the enzymatic assay, the purified enzyme remains bound to either Superose 6 or TSK-40-XL HPLC columns, while the interaction of the crude glucosylceramidase contained in the water extract of the lysosome-mitochondrial fraction of placenta with the two HPLC gel matrices is much weaker.	Water	203-208	glucosylceramidase beta	Homo sapiens	167-185
7513040-2	1994	In rats water-immersion restraint stress resulted in a shortening of euglobulin clot lysis time (ECLT), an increase in tissue plasminogen activator (tPA) activity with a concurrent fall in its inhibitor activity.	Water	8-13	plasminogen activator, tissue type	Rattus norvegicus	119-147
7513040-2	1994	In rats water-immersion restraint stress resulted in a shortening of euglobulin clot lysis time (ECLT), an increase in tissue plasminogen activator (tPA) activity with a concurrent fall in its inhibitor activity.	Water	8-13	plasminogen activator, tissue type	Rattus norvegicus	149-152
8007781-4	1994	The application of frequency selective chemical shift imaging (SENEX) exhibited skin changes similar to those of scleroderma with increased water content and thickened cutis in the water selective images.	Water	181-186	Rho GTPase activating protein 18	Homo sapiens	63-68
23951997-5	2013	To contribute to this effort, we here study an optical probe, N-acetylaladanamide (NAAA), in the presence of a POPC lipid bilayer using a multiscale integrated approach to assess the probe structure, dynamics, and optical properties in its membrane-bound status and in water solvent.	Water	269-274	N-acylethanolamine acid amidase	Homo sapiens	83-87
23791849-7	2013	Baclofen did not change the Uosm/Posm or AQP2 expression in desmopressin-treated rats; but it increased the UFR and diminished the Uosm/Posm and AQP2 expression in water-deprived animals.	Water	164-169	aquaporin 2	Rattus norvegicus	145-149
24013379-4	2013	Horse heart cytochrome c (cyt.c) was dissolved selectively in IL phase by improving the water content of IL phase, and spectroscopic analysis revealed that the dissolved cyt.c retained its higher ordered structure.	Water	88-93	cytochrome c, somatic	Equus caballus	12-24
8253212-3	1993	Our data support the notion that the terminal beta 1,6-linked GlcNAc unit of GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc may interact with the reducing end GlcNAc unit intramolecularly in water solution.	Water	195-200	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	84-92
8132877-0	1993	Thermal behavior of bovine lactoferrin in water and its relation to bacterial interaction and antibacterial activity.	Water	42-47	lactotransferrin	Bos taurus	27-38
24013379-4	2013	Horse heart cytochrome c (cyt.c) was dissolved selectively in IL phase by improving the water content of IL phase, and spectroscopic analysis revealed that the dissolved cyt.c retained its higher ordered structure.	Water	88-93	cytochrome c, somatic	Equus caballus	26-31
8132877-1	1993	Heat-induced enthalpy changes in different forms of bovine lactoferrin in water were examined by differential scanning calorimetry.	Water	74-79	lactotransferrin	Bos taurus	59-70
24013379-4	2013	Horse heart cytochrome c (cyt.c) was dissolved selectively in IL phase by improving the water content of IL phase, and spectroscopic analysis revealed that the dissolved cyt.c retained its higher ordered structure.	Water	88-93	cytochrome c, somatic	Equus caballus	170-175
24052929-7	2013	Evidence from geochemical study of borehole and the lagoon water samples corroborated the ERT result.	Water	59-64	E74 like ETS transcription factor 3	Homo sapiens	90-93
23708614-0	2013	DFT and MP2 study of low barrier proton transfer in hydrazide schiff base tautomers via water bridges and in the gas.	Water	88-93	tryptase pseudogene 1	Homo sapiens	8-11
26877923-2	2013	Aquaporin-2 (AQP2) is the vasopressin-regulated water-channel protein expressed at the connecting tubule and collecting duct, and plays a key role in urine concentration and body-water homeostasis through short-term and long-term regulation of collecting duct water permeability.	Water	179-184	aquaporin 2	Homo sapiens	0-11
26877923-2	2013	Aquaporin-2 (AQP2) is the vasopressin-regulated water-channel protein expressed at the connecting tubule and collecting duct, and plays a key role in urine concentration and body-water homeostasis through short-term and long-term regulation of collecting duct water permeability.	Water	179-184	aquaporin 2	Homo sapiens	13-17
26877923-4	2013	Dysregulation of AQP2 has been shown to be importantly associated with a number of clinical conditions characterized by body-water balance disturbances, including hereditary nephrogenic diabetes insipidus (NDI), lithium-induced NDI, electrolytes disturbance, acute and chronic renal failure, ureteral obstruction, nephrotic syndrome, congestive heart failure, and hepatic cirrhosis.	Water	125-130	aquaporin 2	Homo sapiens	17-21
24083098-3	2013	This article describes the prediction of sea water intrusion into the lease area of whole mining block using Ghyben-Herzberg relation between fresh and saline water, Remote Sensing, Ground Truth verification, Electrical Resistivity Survey and groundwater table monitored during the year 2004.	Water	45-50	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	41-44
23830519-5	2013	We demonstrate here a role for AQP5 in the palmoplantar epidermis and propose that the altered AQP5 proteins retain the ability to form open channels in the cell membrane and conduct water.	Water	183-188	aquaporin 5	Homo sapiens	95-99
23219090-4	2013	RESULTS: We found that the plasma levels of TNF-alpha, CRP, MPO, vascular permeability and water content of heart, lung, kidney, and small intestine tissues were significantly increased in animals after scald injury, and administration of ulinastatin lowered the levels TNF-alpha, CRP, MPO, vascular permeability and water content of those organ tissues.	Water	317-322	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	239-250
24212704-1	2013	Uroguanylin (UGN) is an endogenous peptide that acts on membrane-bound guanylate cyclase receptors of intestinal and renal cells increasing cGMP production and regulating electrolyte and water epithelial transport.	Water	187-192	guanylate cyclase activator 2B	Rattus norvegicus	13-16
23650128-4	2013	We first demonstrated that 5-week exposure of mice to 100 mug/l of arsenic in drinking water stimulated epididymal adipocyte hypertrophy, reduced the adipose tissue expression of perilipin (PLIN1, a lipid droplet coat protein), and increased perivascular ectopic fat deposition in skeletal muscle.	Water	87-92	perilipin 1	Mus musculus	190-195
23531819-3	2013	A cDNA encoding the homologue of the water-specific Drosophila AQP [Drosophila integral protein (DRIP)] was identified through the RT-PCR of RNA isolated from the rectum of the cupreous chafer larvae, Anomala cuprea, a humus and plant root feeder.	Water	37-42	drip	Drosophila melanogaster	68-95
23531819-3	2013	A cDNA encoding the homologue of the water-specific Drosophila AQP [Drosophila integral protein (DRIP)] was identified through the RT-PCR of RNA isolated from the rectum of the cupreous chafer larvae, Anomala cuprea, a humus and plant root feeder.	Water	37-42	drip	Drosophila melanogaster	97-101
23531819-5	2013	When expressed in Xenopus laevis oocytes, Anocu AQP1 showed the hallmarks of aquaporin-mediated water transport but no glycerol or urea permeability, and the reversible inhibition of elevated water transport through 1 mmol l(-1) HgCl2.	Water	96-101	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	48-52
23531819-5	2013	When expressed in Xenopus laevis oocytes, Anocu AQP1 showed the hallmarks of aquaporin-mediated water transport but no glycerol or urea permeability, and the reversible inhibition of elevated water transport through 1 mmol l(-1) HgCl2.	Water	192-197	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	48-52
23531819-6	2013	This is the first experimental demonstration of the presence of a water-specific AQP, namely DRIP, in the Coleoptera.	Water	66-71	drip	Drosophila melanogaster	93-97
23463292-1	2013	Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2.	Water	22-27	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
23463292-1	2013	Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2.	Water	22-27	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
23463292-1	2013	Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2.	Water	75-80	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
23463292-1	2013	Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2.	Water	75-80	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
23766555-0	2013	Electron Paramagnetic Resonance and Electron Spin Echo Studies of Co2+ Coordination by Nicotinamide Adenine Dinucleotide (NAD+) in Water Solution.	Water	131-136	complement C2	Homo sapiens	66-69
23766555-1	2013	Co2+ binding to the nicotinamide adenine dinucleotide (NAD+) molecule in water solution was studied by electron paramagnetic resonance (EPR) and electron spin echo at low temperatures.	Water	73-78	complement C2	Homo sapiens	0-3
23658054-0	2013	Enhancing operational stability and exhibition of enzyme activity by removing water in the immobilized lipase-catalyzed production of erythorbyl laurate.	Water	78-83	PAN0_003d1715	Moesziomyces antarcticus	103-109
23413977-5	2013	Members of ac1 and LD2 were significantly more enriched after NAG addition to lake water.	Water	83-88	long intergenic non-protein coding RNA 1587	Homo sapiens	11-14
24350484-4	2013	Sludge, sludge sintered at 400 and 600 degrees C, and sea sand suppressed phosphorus release from sediments into the overlying water, whereas sludge and sludge sintered at 200 degrees C increased nitrogen release relative to that without capping.	Water	127-132	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	54-57
23616425-2	2013	AQP4 has been described as an important entry and exit site for water during formation of brain edema and regulation of AQP4 is therefore of therapeutic interest.	Water	64-69	aquaporin 4	Rattus norvegicus	0-4
23616425-4	2013	Protein kinase (PK)-dependent phosphorylation of Ser(111) has been reported to increase the water permeability of AQP4 expressed in an astrocytic cell line.	Water	92-97	aquaporin 4	Rattus norvegicus	114-118
23722907-6	2013	Mice overexpressing soluble VEGFR3 in epidermal keratinocytes exhibited hypoplastic cutaneous lymph capillaries and increased Na+, Cl-, and water retention in skin and salt-sensitive hypertension.	Water	140-145	FMS-like tyrosine kinase 4	Mus musculus	28-34
7693817-7	1993	2) Low dose feeding induced resistance to EAU induction by a distinct, spatially separate peptide, residues 270-289, of S-Ag.	Water	42-45	S-antigen visual arrestin	Rattus norvegicus	120-124
7693817-10	1993	Conversely, induction of tolerance with high doses of peptide (5 mg/feeding) resulted in loss of resistance to EAU induced by S-Ag, although disease induction by the fed peptide was inhibited; observations that are consistent with clonal anergy.	Water	111-114	S-antigen visual arrestin	Rattus norvegicus	126-130
2076566-8	1990	The reason was assumed to be that the smaller particle size offered the greater oil-water interface for lipase activity against AL-294.	Water	84-89	lipase G, endothelial type	Rattus norvegicus	104-110
23751065-10	2013	When ATP is placed in the ADP-bound conformation of Eg5, the ATP-Mg moiety is surrounded by many water molecules and Thr107 blocks the water chain, which together make the hydrolysis reaction less favorable.	Water	97-102	kinesin family member 11	Homo sapiens	52-55
2223837-1	1990	Fourier transform infrared spectroscopy has been used to investigate the secondary structure of porcine and bovine pancreatic phospholipase A2 (PLA2) and the zymogen of porcine PLA2, prophospholipase A2 (proPLA2), in both H2O and D2O media.	Water	222-225	LOC104974671	Bos taurus	126-142
2223837-1	1990	Fourier transform infrared spectroscopy has been used to investigate the secondary structure of porcine and bovine pancreatic phospholipase A2 (PLA2) and the zymogen of porcine PLA2, prophospholipase A2 (proPLA2), in both H2O and D2O media.	Water	222-225	LOC104974671	Bos taurus	177-181
8404644-9	1993	We were able to demonstrate aromatase activity by assaying the incorporation of tritium into [3H] water from [1 beta-3H]androstenedione.	Water	98-103	aromatase	Bos taurus	28-37
23751065-10	2013	When ATP is placed in the ADP-bound conformation of Eg5, the ATP-Mg moiety is surrounded by many water molecules and Thr107 blocks the water chain, which together make the hydrolysis reaction less favorable.	Water	135-140	kinesin family member 11	Homo sapiens	52-55
23751065-11	2013	The observed two-water chain mechanisms are rather similar to those suggested in two other motors, myosin and F1-ATPase, raising the possibility of a common mechanism.	Water	17-22	myosin heavy chain 14	Homo sapiens	99-105
8227331-4	1993	uPAR from ascitic fluids partitions in the water phase after a temperature-dependent phase separation of a detergent extract.	Water	43-48	plasminogen activator, urokinase receptor	Homo sapiens	0-4
2271572-3	1990	Rapid-flow resonance Raman spectra have been obtained of 7,9-dicis-rhodopsin in H2O and D2O at room temperature.	Water	80-83	rhodopsin	Bos taurus	67-76
23470663-12	2013	The present and previous RBC studies indicate that anion (AE1), urea (UT-B) and water (AQP1) transporters only transport chloride (all species), water (duck, dog, human) and urea (Amphiuma, dog, human), respectively.	Water	80-85	aquaporin-1	Canis lupus familiaris	87-91
8224100-3	1993	Mixtures of CCl4 with water-soluble vehicles were used to improve the dispersion of CCl4 in the medium.	Water	22-27	C-C motif chemokine ligand 4	Homo sapiens	84-88
8224100-5	1993	The performance of ethanol and, to a lesser degree, other alcohols, suggests the existence of a water stable structural organization between CCl4 and these amphiphilic vehicles, facilitating the transfer of CCl4 to the membrane.	Water	96-101	C-C motif chemokine ligand 4	Homo sapiens	141-145
8224100-5	1993	The performance of ethanol and, to a lesser degree, other alcohols, suggests the existence of a water stable structural organization between CCl4 and these amphiphilic vehicles, facilitating the transfer of CCl4 to the membrane.	Water	96-101	C-C motif chemokine ligand 4	Homo sapiens	207-211
23470663-12	2013	The present and previous RBC studies indicate that anion (AE1), urea (UT-B) and water (AQP1) transporters only transport chloride (all species), water (duck, dog, human) and urea (Amphiuma, dog, human), respectively.	Water	145-150	aquaporin-1	Canis lupus familiaris	87-91
23438451-3	2013	Here we demonstrate that in obesity, early steatohepatitic lesions induced by the water disinfection byproduct bromodichloromethane are mediated by increased oxidative stress and leptin which act in synchrony to potentiate disease progression.	Water	82-87	leptin	Mus musculus	179-185
8218923-3	1993	The aggregation of NaDC and NaC in water can be monitored by CD measurements.	Water	35-40	synuclein alpha	Homo sapiens	28-31
8403665-5	1993	The extent to which extracellular attachments were required for induced cartilage development was reflected in the quantity of cartilage formed when BMP/NCP, either in insoluble or in water-soluble form, was introduced was greatest on GuHCl-extracted bone matrix.	Water	184-189	bone morphogenetic protein 1	Homo sapiens	149-152
8403665-9	1993	Water-soluble human BMP induced development of masses of amorphous cartilage.	Water	0-5	bone morphogenetic protein 1	Homo sapiens	20-23
1979846-6	1990	The concentration of leukotriene C4 in brain tissue increased significantly during reperfusion: treatment with a 5-lipoxygenase inhibitor, AA-861, decreased the increase of brain water content associated with reperfusion.	Water	179-184	arachidonate 5-lipoxygenase	Rattus norvegicus	113-127
2152343-4	1990	Another sequence family encodes the water stress-induced protein osmotin [Singh et al.	Water	36-41	osmotin	Nicotiana tabacum	65-72
23583686-3	2013	Allele-competitive blocker PCR (ACB-PCR) was used to investigate the induction of a sensitive, tumor-relevant mutation, specifically in vivo K-Ras codon 12 GAT mutation, in scraped duodenal epithelium following 90 days of drinking water exposure.	Water	231-236	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	141-146
2166557-1	1990	Human little gastrin is a 17 amino acid peptide that adopts a random conformation in water and an ordered structure in sodium dodecyl sulfate (SDS) micelles as well as in trifluoroethanol (TFE).	Water	85-90	gastrin	Homo sapiens	13-20
8223581-2	1993	In this paper, we demonstrate the existence of enzymically active water-soluble forms of PC-1 in ascites from plasmacytoma-bearing mice, normal mouse serum, and in supernatants of cultured mouse plasmacytoma cells and mouse L cells transfected with a cDNA encoding the membrane form of PC-1.	Water	66-71	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	89-93
8223581-2	1993	In this paper, we demonstrate the existence of enzymically active water-soluble forms of PC-1 in ascites from plasmacytoma-bearing mice, normal mouse serum, and in supernatants of cultured mouse plasmacytoma cells and mouse L cells transfected with a cDNA encoding the membrane form of PC-1.	Water	66-71	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	286-290
8223581-3	1993	The water-soluble enzyme activity can be specifically immunoprecipitated by a monoclonal antibody to an allotypic determinant on the membrane form of PC-1, and resides on a slightly smaller polypeptide than membrane PC-1.	Water	4-9	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	150-154
8223581-3	1993	The water-soluble enzyme activity can be specifically immunoprecipitated by a monoclonal antibody to an allotypic determinant on the membrane form of PC-1, and resides on a slightly smaller polypeptide than membrane PC-1.	Water	4-9	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	216-220
23668422-0	2013	Alkaline post-treatment of Cd(II)-glutathione coordination polymers: toward green synthesis of water-soluble and cytocompatible CdS quantum dots with tunable optical properties.	Water	95-100	CDP-diacylglycerol synthase 1	Homo sapiens	128-131
2344622-11	1990	The potent uveitopathogenicity of peptides from this region indicates that it is a major pathogenic site responsible for EAU induced in LEW rats by immunization with human S-Ag.	Water	121-124	S-antigen visual arrestin	Homo sapiens	172-176
23668422-1	2013	In this study, we demonstrate a facile and environmentally friendly method for the synthesis of glutathione (GSH)-capped water-soluble CdS quantum dots (QDs) with a high cytocompatibility and a tunable optical property based on alkaline post-treatment of Cd-GSH coordination polymers (CPs).	Water	121-126	CDP-diacylglycerol synthase 1	Homo sapiens	135-138
8262695-2	1993	CD-1 outbred mice were exposed for 28 days to relatively low doses of 25-100 ppm HgCl2 in drinking water and the mercury-related functional cellular changes were validated in a macrophage phagocytosis assay.	Water	99-104	CD1 antigen complex	Mus musculus	0-4
23668422-4	2013	In addition, the use of GSH as the capping reagent eventually endows the as-formed CdS QDs with enhanced water solubility and good cytocompatibility, as demonstrated with HeLa cells.	Water	105-110	CDP-diacylglycerol synthase 1	Homo sapiens	83-86
23668422-6	2013	This study offers a new and green synthetic route to water-soluble and cytocompatible CdS QDs with tunable optical properties.	Water	53-58	CDP-diacylglycerol synthase 1	Homo sapiens	86-89
23721064-8	2013	Calculations at the MP2 and CCSD(T) level on the bare NH2 + O2 reaction and the reaction of NH2 + O2 in small water clusters were carried out.	Water	110-115	tryptase pseudogene 1	Homo sapiens	20-23
8357792-6	1993	The structure of p21 (G12P) is remarkably similar to that of wild-type p21 in the active site, including the position of the nucleophilic water.	Water	138-143	H3 histone pseudogene 16	Homo sapiens	17-20
1970292-10	1990	This activity, attributed to a cytotropic factor (CTF), was inactivated by heating for 10 min in a boiling water bath, but was unaffected by trypsin digestion.	Water	107-112	nuclear factor I/A	Rattus norvegicus	31-48
1970292-10	1990	This activity, attributed to a cytotropic factor (CTF), was inactivated by heating for 10 min in a boiling water bath, but was unaffected by trypsin digestion.	Water	107-112	nuclear factor I/A	Rattus norvegicus	50-53
23462572-3	2013	After the injection of a high replacement dose (0.04 mg/kg) and two pharmacologic doses (4 and 8 mg/kg) of leptin, brain water contents increased significantly compared with that of control mice (P&lt;0.05), which was confirmed when comparing the results with leptin-deficient ob/ob and wild-type (WT) mice (78.8%+-0.6% versus 79.7%+-0.6%, P&lt;0.05).	Water	121-126	leptin	Mus musculus	107-113
8395817-13	1993	A Gly-207 to Pro mutation, therefore, results in the creation of a larger substrate pocket in the mutant cytochrome P-450 by altering the protein structure around residue 209 so that a water molecule and testosterone can be accommodated.	Water	185-190	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	105-121
2191976-4	1990	However cavitational activity around the tip within the water supply appeared to produce an area of erosion (0.66 +/- 0.3 mm2, 1 SD, n = 10), and the surface appeared pitted.	Water	56-61	TOR signaling pathway regulator	Homo sapiens	41-44
23583528-9	2013	CONCLUSIONS: Incorporating DMADDM-NAg-NACP in bonding agent yielded potent and long-lasting antibacterial properties, and much stronger bond strength after 6 months of water-ageing than a commercial control.	Water	168-173	synuclein alpha	Homo sapiens	38-42
8257730-5	1993	In addition, the effect of freeze-drying on the 600 MHz 1H-NMR spectrum of human cerebrospinal fluid (CSF) is presented using both lyophilization with reconstitution into either H2O or D2O.	Water	178-181	colony stimulating factor 2	Homo sapiens	81-106
23592763-2	2013	Aquaporin-4 (AQP-4) is important in cerebral water movement.	Water	45-50	aquaporin 4	Rattus norvegicus	0-11
8349109-1	1993	The enzyme catalase protects aerobic organisms from oxygen-free radical damage by converting hydrogen peroxide to molecular oxygen and water before it can decompose to form the highly reactive hydroxyl radical.	Water	135-140	Catalase	Drosophila melanogaster	11-19
2218100-3	1990	Twitch Pdi at FRC was 24.4 cm H2O.	Water	30-33	peptidyl arginine deiminase 1	Homo sapiens	7-10
2218100-4	1990	At lung volumes above FRC, twitch Pdi decreased by 7.04 +/- 3.2 cm H2O per litre of volume change.	Water	67-70	peptidyl arginine deiminase 1	Homo sapiens	34-37
23592763-2	2013	Aquaporin-4 (AQP-4) is important in cerebral water movement.	Water	45-50	aquaporin 4	Rattus norvegicus	13-18
23542497-7	2013	Average pressure-broadening parameters were found to be 0.0216 cm(-1)/atm and 0.0209 cm(-1)/atm for H2O in (3)He and (4)He, respectively, and were compared to a literature model for the mass-dependence of line broadening.	Water	100-103	ATM serine/threonine kinase	Homo sapiens	92-95
1366523-0	1990	Enzymatic synthesis of the precursor of Leu-enkephalin in water-immiscible organic solvent systems.	Water	58-63	prodynorphin	Homo sapiens	40-54
8153926-5	1993	RESULTS: Mean (SD) sniff PDI was 149 (32) cm H2O in men and 127 (22) cm H2O in women.	Water	45-48	peptidyl arginine deiminase 1	Homo sapiens	25-28
8153926-6	1993	The lower limits of normal for sniff PDI (mean -1.96 x SD) after logarithmic transformation of the data were 95 and 78 cm H2O in men and women respectively.	Water	122-125	peptidyl arginine deiminase 1	Homo sapiens	37-40
23536286-6	2013	In conclusion, an acetylene-containing atmosphere could contribute to the origin of nucleobases in the presence of a urea/water system by an HCN-independent mechanism.	Water	122-127	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	141-144
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Water	106-111	interleukin 1 alpha	Homo sapiens	44-63
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Water	106-111	interleukin 1 alpha	Homo sapiens	65-69
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Water	106-111	interleukin 1 alpha	Homo sapiens	181-185
1689591-1	1990	The longitudinal, transverse, and spin-locked rotating frame relaxation rates have been measured for water protons in aqueous solutions of the human serum proteins albumin, fibrinogen, and alpha 2-macroglobulin in the physiological concentration range below 50 g/liter, corresponding to an upper limit for molarity of 725, 147, and 69 microM, respectively.	Water	101-106	alpha-2-macroglobulin	Homo sapiens	189-210
23560873-8	2013	Finally, we apply the method to rank the energetic contributions of individual atomic MTP coefficients for molecules solvated in water.	Water	129-134	metallothionein 1B	Homo sapiens	86-89
23565745-5	2013	Surface bridging oxygen (Obr) is found to play a decisive role in water adsorption forming rooted hydroxyl groups with the water H atoms.	Water	66-71	leptin receptor	Homo sapiens	25-28
2383642-9	1990	The calculated one- and two-water bridges in the rGpC hydration complex coincide in a number of cases to those observed in the ordered water structure of the sodium rGpC crystal hydrate.	Water	28-33	glycophorin C	Rattus norvegicus	49-53
2383642-9	1990	The calculated one- and two-water bridges in the rGpC hydration complex coincide in a number of cases to those observed in the ordered water structure of the sodium rGpC crystal hydrate.	Water	28-33	glycophorin C	Rattus norvegicus	165-169
2383642-9	1990	The calculated one- and two-water bridges in the rGpC hydration complex coincide in a number of cases to those observed in the ordered water structure of the sodium rGpC crystal hydrate.	Water	135-140	glycophorin C	Rattus norvegicus	49-53
8504476-10	1993	Oral feeding of GTP and WEGT in drinking water also showed significant enhancement in the activities of glutathione S-transferase and NADP(H): quinone reductase in liver, small bowel, stomach and lung.	Water	41-46	hematopoietic prostaglandin D synthase	Mus musculus	104-129
23619802-0	2013	Water exchange on a geological timescale - examples from two coastal sites in the Baltic Sea.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	89-92
8387531-4	1993	PDGF induced a threefold increase in release of water-soluble inositol phosphates in C3H 10T1/2 fibroblasts when cells were attached to FN, but had little effect in suspended cells.	Water	48-53	fibronectin 1	Mus musculus	136-138
2383642-9	1990	The calculated one- and two-water bridges in the rGpC hydration complex coincide in a number of cases to those observed in the ordered water structure of the sodium rGpC crystal hydrate.	Water	135-140	glycophorin C	Rattus norvegicus	165-169
23733285-4	2013	While controlling for several risk factors, this research bridges two different, but complementary research lines by investigating statistically the relationship on suicide mortality between lithium levels in drinking water in response to altitude above sea level.	Water	218-223	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	51-54
2397166-5	1990	The hydrated magnesium ions, [Mg(H2O)6]2+, will most probably break important hydrogen bonds in the clusters of water (H2O)n, where n = 2, 3, 4, 5, 6.../forming new hydrogen bonds in the presence of hexa-aquated magnesium cations.	Water	33-36	hexosaminidase subunit alpha	Homo sapiens	199-203
8463351-8	1993	The advancing and receding contact angle behavior of the PAPI-based additive loaded PEUU films deviated markedly from the behavior of PEUU A", suggesting that the additives were present at the PEUU-water interface.	Water	198-203	pyroglutamyl-peptidase I	Homo sapiens	57-61
23271129-1	2013	The potassium voltage-gated channel, KQT-like subfamily member 1 (KCNQ1) is a member of 11 mammalian Kv channel families that plays a key role for the repolarization of the cardiac action potential as well as water and salt transport.	Water	209-214	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	4-64
8384565-0	1993	Histamine H3 receptor-mediated modulation of water consumption in the rat.	Water	45-50	histamine receptor H3	Rattus norvegicus	0-21
8429910-5	1993	Here we report the cloning of the complementary DNA for WCH-CD, a water channel of the apical membrane of the kidney collecting tubule.	Water	66-71	aquaporin 2	Rattus norvegicus	56-62
8429910-9	1993	Expression of WCH-CD in Xenopus oocytes markedly increases osmotic water permeability.	Water	67-72	aquaporin 2	Rattus norvegicus	14-20
8449029-5	1993	EAU was actively induced in Lewis rats by immunization with S-antigen in Hunter"s adjuvant.	Water	0-3	S-antigen visual arrestin	Rattus norvegicus	60-69
2397166-5	1990	The hydrated magnesium ions, [Mg(H2O)6]2+, will most probably break important hydrogen bonds in the clusters of water (H2O)n, where n = 2, 3, 4, 5, 6.../forming new hydrogen bonds in the presence of hexa-aquated magnesium cations.	Water	112-117	hexosaminidase subunit alpha	Homo sapiens	199-203
2397166-5	1990	The hydrated magnesium ions, [Mg(H2O)6]2+, will most probably break important hydrogen bonds in the clusters of water (H2O)n, where n = 2, 3, 4, 5, 6.../forming new hydrogen bonds in the presence of hexa-aquated magnesium cations.	Water	119-122	hexosaminidase subunit alpha	Homo sapiens	199-203
2342486-1	1990	The water soluble carbodiimide 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide was used to covalently link carboxyl groups on rabbit IgG to lysyl groups on complement protein C1q.	Water	4-9	complement C1q A chain	Homo sapiens	173-176
2310520-5	1990	For a given nucleotide, R1p for the purine H(8) signal was larger than for the H(2) signal with the [Cr(III)(H2O)6]3+ probe, while R1p for the H(2) signal was larger with all the other Cr(III) probes.	Water	109-112	CD1b molecule	Homo sapiens	24-27
1691014-5	1990	Both alpha 1 and alpha 3 form stable monolayers at the air-water interface.	Water	59-64	adrenoceptor alpha 1D	Homo sapiens	5-22
2301577-3	1990	In this study we examined the influence of local intrarterial infusions of PAF (4, 20, and 40 ng/min) on intestinal transcapillary, lymphatic, and transmucosal water and protein fluxes.	Water	160-165	PCNA clamp associated factor	Homo sapiens	75-78
2179968-1	1990	It has previously been described that water intake in thirsty rats require higher doses of dopamine (DA) D-1 and D-2 antagonists to be attenuated than operant lever-pressing with water as reward.	Water	38-43	solute carrier family 3 member 1	Rattus norvegicus	113-116
33798816-0	2021	Long-term water quality analysis reveals correlation between bacterial pollution and sea level rise in the northwestern Gulf of Mexico.	Water	10-15	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
33775364-5	2021	In the loss-of-function rabe1c mutant, both stomatal closure and the whole plant drought stress response showed a reduced sensitivity to ABA treatment, demonstrating that RabE1c is involved in the control over transpirative water loss through the stomata.	Water	224-229	RAB GTPase homolog 8A	Arabidopsis thaliana	24-30
33775364-5	2021	In the loss-of-function rabe1c mutant, both stomatal closure and the whole plant drought stress response showed a reduced sensitivity to ABA treatment, demonstrating that RabE1c is involved in the control over transpirative water loss through the stomata.	Water	224-229	RAB GTPase homolog 8A	Arabidopsis thaliana	171-177
33794088-4	2021	Herein, we prepared water-soluble poly[3-[[2-(diethylamino)ethyl]thio]-1-propyl isocyanate-ran-hexyl isocyanate] (P(DETPIC-ran-HIC)) to investigate the ability of polyisocyanates to inhibit hydrate formation.	Water	20-25	MyoD family inhibitor domain containing	Homo sapiens	127-130
33815074-9	2020	When miR-96 was downregulated or SV2C was overexpressed via intra-cerebroventricular injection with a miR-96 antagonist (miR-96 antagomir) or overexpression of SV2C vector, the Novel Object Recognition Test and sucrose preference index were increased, whereas the escape latency, the number of water maze platform crossings, and the immobility time of the mice were decreased.	Water	294-299	synaptic vesicle glycoprotein 2c	Mus musculus	33-37
23271129-1	2013	The potassium voltage-gated channel, KQT-like subfamily member 1 (KCNQ1) is a member of 11 mammalian Kv channel families that plays a key role for the repolarization of the cardiac action potential as well as water and salt transport.	Water	209-214	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	66-71
23637922-6	2013	We made a PLGA based protective antigen domain 4 nanoparticle (PAD4-NP) formulation using water/oil/water solvent evaporation method.	Water	90-95	MMTV LTR integration site 4	Mus musculus	63-67
33801806-3	2021	The present study analyzed the sanitation efficacy of various concentrations of water-solved ClO2 (cClO2: 20 and 30 mg L-1) on Escherichia coli (1.1 x 104 cfu mL-1), Salmonella enterica (2.0 x 104 cfu mL-1) and Listeria monocytogenes (1.7 x 105 cfu mL-1) loads, located on the leaf surface of iceberg lettuce assigned for fresh-cut salads.	Water	80-85	L1 cell adhesion molecule	Mus musculus	119-122
33801806-3	2021	The present study analyzed the sanitation efficacy of various concentrations of water-solved ClO2 (cClO2: 20 and 30 mg L-1) on Escherichia coli (1.1 x 104 cfu mL-1), Salmonella enterica (2.0 x 104 cfu mL-1) and Listeria monocytogenes (1.7 x 105 cfu mL-1) loads, located on the leaf surface of iceberg lettuce assigned for fresh-cut salads.	Water	80-85	L1 cell adhesion molecule	Mus musculus	201-205
33801806-3	2021	The present study analyzed the sanitation efficacy of various concentrations of water-solved ClO2 (cClO2: 20 and 30 mg L-1) on Escherichia coli (1.1 x 104 cfu mL-1), Salmonella enterica (2.0 x 104 cfu mL-1) and Listeria monocytogenes (1.7 x 105 cfu mL-1) loads, located on the leaf surface of iceberg lettuce assigned for fresh-cut salads.	Water	80-85	L1 cell adhesion molecule	Mus musculus	201-205
33808009-6	2021	In addition, GO-Met-H2O grids reduce the effect of preferred orientation of biological macromolecules within the amorphous ice.	Water	20-23	SAFB like transcription modulator	Homo sapiens	16-19
33808009-7	2021	The power-spectrum and contrast-transfer-function unequivocally suggest that GO-Met-H2O fabricated holey grids have excellent potential for application in high-resolution structural characterization of biomolecules.	Water	84-87	SAFB like transcription modulator	Homo sapiens	80-83
33237088-0	2020	CoP and Ni2P implanted in a hollow porous N-doped carbon polyhedron for pH universal hydrogen evolution reaction and alkaline overall water splitting.	Water	134-139	caspase recruitment domain family member 16	Homo sapiens	0-3
27500935-5	2016	Repeated water avoidance stress (rWAS) in B6-Tcra-/- mice severely exacerbated colitis, which was evaluated by both colorectal tissue weight and histological score of colitis.	Water	9-14	T cell receptor alpha chain	Mus musculus	45-49
8475827-7	1993	These findings suggest that only one non-MHC gene controls the susceptibility to S-Ag induced EAU in rats.	Water	94-97	S-antigen visual arrestin	Rattus norvegicus	81-85
23637922-6	2013	We made a PLGA based protective antigen domain 4 nanoparticle (PAD4-NP) formulation using water/oil/water solvent evaporation method.	Water	100-105	MMTV LTR integration site 4	Mus musculus	63-67
23482963-0	2013	Ultra-stable CdS incorporated Ti-MCM-48 mesoporous materials for efficient photocatalytic decomposition of water under visible light illumination.	Water	107-112	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
25011530-7	2015	The increased sea level scenarios also show that the ground water levels would increase significantly with associated implications for flood protection in the urbanized areas of southeastern Florida.	Water	60-65	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	14-17
23303413-3	2013	Semiquantitative immunoblotting revealed that renal expression of AQP2 and Hsp70 was significantly increased in water-restricted or dDAVP-infused rats.	Water	112-117	aquaporin 2	Rattus norvegicus	66-70
22871834-2	2012	METHODS: EPO-dextran PLGA/PLA microspheres were prepared first by a novel solid-in-oil-in-water (S/O/W) technique.	Water	90-95	erythropoietin	Rattus norvegicus	9-12
23303413-3	2013	Semiquantitative immunoblotting revealed that renal expression of AQP2 and Hsp70 was significantly increased in water-restricted or dDAVP-infused rats.	Water	112-117	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	75-80
23386615-2	2013	Using two independent protein interaction screens, we show that these kinases associate, in an oxidation-dependent manner, with Prdx1, an enzyme that regulates the cellular redox state by reducing hydrogen peroxide to water and oxygen.	Water	218-223	peroxiredoxin 1	Homo sapiens	128-133
9691010-1	1998	Experiments were performed to investigate vasopressin type 2 receptor (V2)-mediated renal water reabsorption and the renal expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2) in cirrhotic rats with sodium retention but without ascites.	Water	163-168	aquaporin 2	Rattus norvegicus	190-195
23418063-4	2013	The linear strands of 1 were found to pair up upon eliminating lattice water molecules by heating, which led to the solid-state structural transformation of photostable linear 1D CP 1 into photoreactive ladder CP 2.	Water	71-76	ceruloplasmin	Homo sapiens	210-214
34810015-4	2022	Under optimal conditions, the limits of detection for the analytes at S/N = 3 were 0.02-0.08 ng mL-1 for water, 0.03-0.10 ng mL-1 for peach juice and 0.05-0.16 ng g-1 for honey sample.	Water	105-110	L1 cell adhesion molecule	Mus musculus	96-100
23626540-1	2013	Aquaporin-5 (AQP-5) is a water-transporting protein expressed in mammal sweat glands.	Water	25-30	aquaporin 5	Homo sapiens	0-11
23626540-1	2013	Aquaporin-5 (AQP-5) is a water-transporting protein expressed in mammal sweat glands.	Water	25-30	aquaporin 5	Homo sapiens	13-18
34920220-1	2022	A new strategy that simultaneous use of KHCO3 activated biochar and nano-MgO incorporation for Pb2+ and Cd2+ removal from water was raised.	Water	122-127	CD2 molecule	Homo sapiens	104-107
23967712-5	2013	Drug metabolism is responsible 1. for the conversion of prodrugs into active compounds or conversion of drug to toxic or inactive metabolites mostly through reactions mostly catalysed by cytochromes (CYP) P450 (phase reactions) and 2. for transforming drugs to compounds that are more water soluble and more easily excreted (phase type II reactions).	Water	285-290	peptidylprolyl isomerase G	Homo sapiens	200-203
11537733-3	1993	The highest concentrations in the water column were found in surface waters of the central Pacific gyre (1.5 ng/L) and in the anoxic waters of the Cariaco Trench (1.1 ng/L) and the Black Sea (0.3 ng/L).	Water	34-39	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	187-190
34742969-2	2022	In this study, the comparative transport behaviors of Cd2+ and CrO42- in water-saturated soil columns were investigated under a variety of hydrochemical and hydraulic conditions such as pH, ionic strength (IS), and flow rate.	Water	73-78	CD2 molecule	Homo sapiens	54-57
23404086-0	2013	Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions.	Water	73-78	CD79b molecule	Homo sapiens	31-34
34743904-3	2022	The Baltic Sea represents an excellent example of eutrophication-related massive bottom water deoxygenation since 1950s, when the nutrient inputs derived from agricultural fertilisers and wastewater discharges increased significantly.	Water	88-93	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	11-14
8069567-4	1993	An aqueous formulation and a water in oil emulsion of a lipophilic salt, a decane sulfonic acid derivative of [D-Leu6-desGly10]LH-RH ethylamide gave ID bioavailabilities of approximately 0.2% and 1%, respectively.	Water	29-34	gonadotropin releasing hormone 1	Rattus norvegicus	127-132
23404086-0	2013	Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions.	Water	86-91	CD79b molecule	Homo sapiens	31-34
22924690-6	2013	UV/Vis and fluorescence studies indicated that Pc9 is less aggregated upon encapsulation in comparison with Pc9 in water-DMSO 2% and remained photostable.	Water	115-120	proprotein convertase subtilisin/kexin type 9	Homo sapiens	47-50
1450215-1	1992	Bee venom phospholipase A2 (BV-PLA2) is a hydrolytic enzyme that specifically cleaves the sn-2 acyl bond of phospholipids at the lipid/water interface.	Water	135-140	phospholipase A2	Apis mellifera	10-26
34973381-0	2022	Fabricating BiOI nanostructures armed catalytic strips for selective electrochemical and SERS detection of pesticide in polluted water.	Water	129-134	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	89-93
22924690-6	2013	UV/Vis and fluorescence studies indicated that Pc9 is less aggregated upon encapsulation in comparison with Pc9 in water-DMSO 2% and remained photostable.	Water	115-120	proprotein convertase subtilisin/kexin type 9	Homo sapiens	108-111
22924690-8	2013	Photocytotoxicity assays using human nasopharynx KB carcinoma cells confirmed that the encapsulation of Pc9 in T1107 and T1307 increases its photocytotoxicity by 10 times in comparison with the free form in water-DMSO.	Water	207-212	proprotein convertase subtilisin/kexin type 9	Homo sapiens	104-107
1286529-10	1992	During KCl infusion, the known increase in tubular delivery of salt and water to the duct would allow full expression of the downstream ANF effect, accounting for the relatively greater diuresis and saluresis in the transgenic mice.	Water	72-77	natriuretic peptide type A	Mus musculus	136-139
34971941-0	2022	Denaturation manner of sarcoplasmic proteins in Pale, Soft and Exudative meat determines their positive impacts on myofibrillar water-holding capacity.	Water	128-133	POC1 centriolar protein A	Homo sapiens	54-58
23188468-5	2013	RESULTS: A global analysis of brain water content by the wet/dry weight method allowed optimizing the SR49059 dosage, and demonstrated the down-regulation of brain AQP4 expression by immunoblotting.	Water	36-41	aquaporin 4	Rattus norvegicus	164-168
34954487-3	2022	The mechanism of the solution degradation chemistry was verified by stressing linagliptin API with trimethylsilyl cyanide (TMSCN, which can give off HCN slowly in the presence of water) treated with sonication in the sample preparation.	Water	179-184	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	149-152
1416971-11	1992	Complex formation between the NADPH-cytochrome P450 reductase and cytochrome P450 LM2 monomers was not detected by recording the difference binding spectra of the reductase monomers with LM2 monomers or by treatment the mixture of the monomers of the proteins with the crosslinking reagent, water-soluble carbodiimide.	Water	291-296	cytochrome P450 2B4	Oryctolagus cuniculus	66-85
23015545-0	2013	Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel.	Water	80-85	aquaporin 2	Canis lupus familiaris	68-79
1461170-4	1992	Elements in the hypothesis include the ability of relatively low concentrations of lithocholic acid to inhibit isoforms of glutathione S-transferase found in colon epithelial cells, entry of lithocholic acid into the epithelial cells, and the correlation of neoplasia-associated colon pathology with high levels of lithocholic acid in fecal water.	Water	341-346	glutathione S-transferase kappa 1	Homo sapiens	123-148
23135701-1	2013	Focus on "Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel".	Water	90-95	aquaporin 2	Homo sapiens	78-89
34742064-6	2022	Notably, as a cathode material for PEC water reduction, AB stacking CTF-1 also demonstrated an excellent saturated photocurrent density up to 77 microA cm-2 at 0 V vs. RHE, which was superior to the AA stacking CTF-1 (47 microA cm-2).	Water	39-44	cardiotrophin 1	Homo sapiens	68-73
24429824-11	2013	CONCLUSIONS: We conclude that the upregulation of pendrin is essential for the prevention of salt and water wasting in NCC deficient animals and its downregulation or inactivation will result in salt wasting, impaired water conservation and volume depletion in the setting of NCC inactivation or inhibition.	Water	102-107	solute carrier family 26, member 4	Mus musculus	50-57
1480520-1	1992	Intrahypothalamic injection of amylin (AMY) was shown to reduce the intake of rat chow and water for 8 and 4 h, respectively, in schedule-fed rats.	Water	91-96	islet amyloid polypeptide	Rattus norvegicus	31-37
1480520-1	1992	Intrahypothalamic injection of amylin (AMY) was shown to reduce the intake of rat chow and water for 8 and 4 h, respectively, in schedule-fed rats.	Water	91-96	islet amyloid polypeptide	Rattus norvegicus	39-42
1480520-2	1992	Amylin also reduced water intake to a much lesser degree in 24-h water-deprived rats.	Water	20-25	islet amyloid polypeptide	Rattus norvegicus	0-6
24429824-11	2013	CONCLUSIONS: We conclude that the upregulation of pendrin is essential for the prevention of salt and water wasting in NCC deficient animals and its downregulation or inactivation will result in salt wasting, impaired water conservation and volume depletion in the setting of NCC inactivation or inhibition.	Water	218-223	solute carrier family 26, member 4	Mus musculus	50-57
1480520-2	1992	Amylin also reduced water intake to a much lesser degree in 24-h water-deprived rats.	Water	65-70	islet amyloid polypeptide	Rattus norvegicus	0-6
1480520-6	1992	Therefore, in addition to other metabolic effects, AMY may be involved in the control of food and water intake.	Water	98-103	islet amyloid polypeptide	Rattus norvegicus	51-54
34772633-8	2022	The developed method was furtherly applied in the determination of nitrite using a developed paper-based analytical device that detected a nitrite concentration of 3 mug mL-1 which is considered by the World Health Organization to be the maximal permissible limit of nitrite in drinking water.	Water	287-292	L1 cell adhesion molecule	Mus musculus	170-174
24429825-1	2013	BACKGROUND: We recently reported that aquaporin 5 (AQP5), a water channel never identified in the kidney before, co-localizes with pendrin at the apical membrane of type-B intercalated cells in the kidney cortex.	Water	60-65	solute carrier family 26, member 4	Mus musculus	131-138
24280641-13	2013	CONCLUSION: cGMP pathway controls water channels and then affects water intake during CPB through an AQP1-mediated pathway.	Water	34-39	aquaporin-1	Ovis aries	101-105
34598033-4	2022	Theoretical calculation of H2O adsorption energy and Bader charges reveals that Mo sites in PBA-SMo possess favourable H2O adsorption kinetics.	Water	27-30	smoothened, frizzled class receptor	Homo sapiens	96-99
1295222-0	1992	[The therapeutic action of the low-water bulk of therapeutic sea mud].	Water	35-40	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	61-64
23478984-0	2013	beta-casein micelle formation in water-ethanol solutions.	Water	33-38	casein beta	Homo sapiens	0-11
1512262-7	1992	In the R2-state, His-97 beta 2 simply rotates away from threonines 38 alpha 1 and 41 alpha 1, breaking contact with these residues and allowing water access to the center of the alpha 1 beta 2 interface.	Water	144-149	adrenoceptor alpha 1D	Homo sapiens	70-92
1512262-7	1992	In the R2-state, His-97 beta 2 simply rotates away from threonines 38 alpha 1 and 41 alpha 1, breaking contact with these residues and allowing water access to the center of the alpha 1 beta 2 interface.	Water	144-149	adrenoceptor alpha 1D	Homo sapiens	70-77
34598033-4	2022	Theoretical calculation of H2O adsorption energy and Bader charges reveals that Mo sites in PBA-SMo possess favourable H2O adsorption kinetics.	Water	119-122	smoothened, frizzled class receptor	Homo sapiens	96-99
34941439-1	2022	BACKGROUND: Pulmonary gas exchange during diving or in a dry hyperbaric environment is affected by increased breathing gas density and possibly water immersion.	Water	144-149	gastrin	Homo sapiens	22-25
23781272-2	2013	Water extracts of Fructus Arctii were shown to inhibit tyrosinase activity in vitro and melanin content in alpha -melanocyte stimulating hormone-stimulated cells to similar levels as the well-known kojic acid and arbutin, respectively.	Water	0-5	tyrosinase	Mus musculus	55-65
34534870-0	2022	Cross-oceanic distribution and origin of microplastics in the subsurface water of the South China Sea and Eastern Indian Ocean.	Water	73-78	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	98-101
23290241-2	2013	To prevent the contamination of fresh produce with hNoV, knowledge of the possible introduction sources of the viruses, such as water, is needed to be able to implement appropriate and efficient preventive measures.	Water	128-133	cellular communication network factor 3	Homo sapiens	51-55
1498337-6	1992	However, when the apical cell surface was pretreated with anti-TF antibody, washed, and then cells were lysed with water or permeabilized with saponin, similar augmentation of TF activity was still observed, suggesting the presence of a pool of TF to which the antibody did not initially gain access.	Water	115-120	coagulation factor III, tissue factor	Homo sapiens	176-178
1498337-6	1992	However, when the apical cell surface was pretreated with anti-TF antibody, washed, and then cells were lysed with water or permeabilized with saponin, similar augmentation of TF activity was still observed, suggesting the presence of a pool of TF to which the antibody did not initially gain access.	Water	115-120	coagulation factor III, tissue factor	Homo sapiens	176-178
23290241-3	2013	Contaminated water used to reconstitute pesticides could be a relevant source of infectious hNoV, determined by the initial level of virus contamination and the persistence of these viruses in reconstituted pesticides.	Water	13-18	cellular communication network factor 3	Homo sapiens	92-96
23290241-9	2013	Assuming a similar persistence of infectious MNV-1 and hNoV we can conclude that water containing hNoV used to dilute pesticides may be an important source of infectious hNoV in fresh produce chains.	Water	81-86	cellular communication network factor 3	Homo sapiens	55-59
20725427-1	1992	We show that sapphire can be superpolished in direct contact with a tin lap by using colloidal silica in water as the polishing liquid.	Water	105-110	LAP	Homo sapiens	72-75
23290241-9	2013	Assuming a similar persistence of infectious MNV-1 and hNoV we can conclude that water containing hNoV used to dilute pesticides may be an important source of infectious hNoV in fresh produce chains.	Water	81-86	cellular communication network factor 3	Homo sapiens	98-102
34655970-4	2022	Herein a novel solution to detect mercury (II) pollution in sea water is proposed, and an easy and portable detection method has been developed.	Water	64-69	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	60-63
23290241-9	2013	Assuming a similar persistence of infectious MNV-1 and hNoV we can conclude that water containing hNoV used to dilute pesticides may be an important source of infectious hNoV in fresh produce chains.	Water	81-86	cellular communication network factor 3	Homo sapiens	98-102
34655970-7	2022	Indeed, this biosensor specifically measure Hg2+ concentration also in the presence of other metals, reaching a limit of detection of 0.4 nM in tap water and 0.3 nM in sea water.	Water	172-177	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	168-171
23515334-4	2013	Fbg microfibers were covalently modified with fibronectin (FN) by using water-soluble 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide as the cross-linking agent.	Water	72-77	fibronectin 1	Mus musculus	46-57
34962378-0	2022	MOF-on-MOF Strategy to Construct a Nitrogen-Doped Carbon-Incorporated CoP@Fe-CoP Core-Shelled Heterostructure for High-Performance Overall Water Splitting.	Water	139-144	caspase recruitment domain family member 16	Homo sapiens	70-73
1613460-7	1992	Likewise, the elevation of brain water content after intracisternal injection of pneumococci or PCW-M was blocked by pretreatment of rats with TGF-beta 2.	Water	33-38	transforming growth factor, beta 2	Rattus norvegicus	143-153
1613460-9	1992	The beneficial effects of TGF-beta 2 on the initial phase after pneumococcal inoculation seem to be tumor necrosis factor alpha- (TNF-alpha) independent since (a) intracisternal or intraperitoneal injection of neutralizing anti-TNF-alpha antibodies did not significantly influence rCBF, ICP, and brain water content in PCW-M-induced meningitis; and (b) TNF-alpha was only occasionally detected at low levels in cerebrospinal fluid at 4 h after PCW-M application.	Water	302-307	transforming growth factor, beta 2	Rattus norvegicus	26-36
1318075-1	1992	The number of water molecules bound to Mn2+ in the complex with a variant of Ha ras p21 and GDP has been determined by electron paramagnetic resonance (EPR) measurements in 17O-enriched water.	Water	14-19	H3 histone pseudogene 16	Homo sapiens	84-87
34962378-0	2022	MOF-on-MOF Strategy to Construct a Nitrogen-Doped Carbon-Incorporated CoP@Fe-CoP Core-Shelled Heterostructure for High-Performance Overall Water Splitting.	Water	139-144	caspase recruitment domain family member 16	Homo sapiens	77-80
23535312-6	2013	Moreover, AC1 was useful in the removal of free residual chlorine in tap water.	Water	73-78	long intergenic non-protein coding RNA 1587	Homo sapiens	10-13
34343809-3	2022	Under the optimum conditions, good linear response for the quantification of the analytes was achieved in the range of 0.3-50.0 ng mL-1 for water samples and in the range of 8.0-500.0 ng g-1 for honey samples.	Water	140-145	L1 cell adhesion molecule	Mus musculus	131-135
1318075-1	1992	The number of water molecules bound to Mn2+ in the complex with a variant of Ha ras p21 and GDP has been determined by electron paramagnetic resonance (EPR) measurements in 17O-enriched water.	Water	186-191	H3 histone pseudogene 16	Homo sapiens	84-87
23184649-3	2013	When sequentially treated (four 16-h overnight exposures) with 100 mM ethanol, the slices display elevated levels of aquaporin-4 (AQP4) water channels accompanied by significant neurodegeneration.	Water	136-141	aquaporin 4	Rattus norvegicus	117-128
34343809-5	2022	The limits of detection at the signal to noise ratio of 3 were measured to be in the range of 0.08-0.12 ng mL-1 for water samples and 2.6-3.3 ng g-1 for honey samples, depending on compounds.	Water	116-121	L1 cell adhesion molecule	Mus musculus	107-111
23184649-3	2013	When sequentially treated (four 16-h overnight exposures) with 100 mM ethanol, the slices display elevated levels of aquaporin-4 (AQP4) water channels accompanied by significant neurodegeneration.	Water	136-141	aquaporin 4	Rattus norvegicus	130-134
24855396-2	2013	T1rho MRI is a measurement that probes the low-frequency rate of exchange between protons of free water and those from water associated with macromolecules in the cartilage"s extracellular matrix.	Water	98-103	CD5 molecule	Homo sapiens	0-9
34814011-2	2022	In mouse models of diabetes and airway inflammation, D-m supplementation via drinking water attenuated pathology by modifying cellular energy metabolism, leading to the activation of latent transforming growth factor beta (TGF-beta), which in turn induced T regulatory cells (Tregs).	Water	86-91	transforming growth factor alpha	Mus musculus	223-231
24855396-2	2013	T1rho MRI is a measurement that probes the low-frequency rate of exchange between protons of free water and those from water associated with macromolecules in the cartilage"s extracellular matrix.	Water	119-124	CD5 molecule	Homo sapiens	0-9
24855396-3	2013	While it has been hypothesized that increased water mobility resulting from early osteoarthritic changes cause elevated T1rho MRI values, there remain several unknown mechanisms influencing T1rho measurements in cartilage.	Water	46-51	CD5 molecule	Homo sapiens	120-129
23555773-8	2013	BGA and BGB showed higher affinity than LacNAc and lactose due to generally stronger hydrogen bond interactions and water mediated hydrogen bonds with alpha1-2 fucose respectively.	Water	116-121	adrenoceptor alpha 1D	Homo sapiens	151-159
34520830-0	2022	Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulation JAK2/STAT3-mediated iNOS expression.	Water	0-5	Janus kinase 2	Mus musculus	127-131
23784001-2	2013	We show that this natural electrification of a droplet originates from the charge separation between a droplet and pipette tip surface by contact with water due to the ionization of surface chemical groups.	Water	151-156	TOR signaling pathway regulator	Homo sapiens	123-126
34896292-4	2022	The cellulose fiber was administrated as a feed additive (100 mg Kg-1 feed), while the probiotics was applied in the water (105 UFC mL-1 culture water).	Water	145-150	L1 cell adhesion molecule	Mus musculus	132-136
23245528-5	2013	While exploiting conserved motifs, the ligand binding and signal transduction pathways work around and through water-containing cavities, an emerging feature of GPCR structures.	Water	111-116	C-X-C motif chemokine receptor 6	Homo sapiens	161-165
34368983-0	2022	New Biochemical Insights into the Dynamics of Water Molecules at the GMP or IMP Binding Site of Human GMPR Enzyme: A Molecular Dynamics Study.	Water	46-51	guanosine monophosphate reductase	Homo sapiens	102-106
24061378-2	2012	Further, the stability constants of the 1 M2+ complexes in water-saturated nitrobenzene were calculated; they were found to increase in the series of Cu2+ &lt; Ba2+ &lt; Zn2+ &lt; Ni2+ &lt; UO22+ &lt; Co2+ &lt; Mn2+ &lt; Cd2+ &lt; Ca2+ &lt; Pb2+.	Water	59-64	CD2 molecule	Homo sapiens	221-224
22988141-11	2012	These findings suggest that TMEM16A expression is particularly required under conditions of mucus hypersecretion to ensure adequate secretion of electrolytes and water.	Water	162-167	anoctamin 1	Homo sapiens	28-35
34918899-6	2021	A systematic study of CO oxidation turnover numbers in the absence and in the presence of hydrogen over the composites loaded with well-calibrated 2-4 nm gold nanoparticles clearly shows that (1) the chemical composition of the support surface has much less impact on PROX (preferential oxidation of CO in excess hydrogen) than on dry CO oxidation, (2) NH2-terminated supports are as active as OH-terminated supports in PROX, (3) hydrogen/water-mediated CO oxidation pathways are active on C3N4-based Au catalysts, and (4) PROX activity requires a rather large porosity (40 nm), which suggests the involvement of much larger intermediates than the usually postulated peroxo-type species.	Water	439-444	pyruvate dehydrogenase complex component X	Homo sapiens	268-272
34918899-6	2021	A systematic study of CO oxidation turnover numbers in the absence and in the presence of hydrogen over the composites loaded with well-calibrated 2-4 nm gold nanoparticles clearly shows that (1) the chemical composition of the support surface has much less impact on PROX (preferential oxidation of CO in excess hydrogen) than on dry CO oxidation, (2) NH2-terminated supports are as active as OH-terminated supports in PROX, (3) hydrogen/water-mediated CO oxidation pathways are active on C3N4-based Au catalysts, and (4) PROX activity requires a rather large porosity (40 nm), which suggests the involvement of much larger intermediates than the usually postulated peroxo-type species.	Water	439-444	pyruvate dehydrogenase complex component X	Homo sapiens	420-424
34918899-6	2021	A systematic study of CO oxidation turnover numbers in the absence and in the presence of hydrogen over the composites loaded with well-calibrated 2-4 nm gold nanoparticles clearly shows that (1) the chemical composition of the support surface has much less impact on PROX (preferential oxidation of CO in excess hydrogen) than on dry CO oxidation, (2) NH2-terminated supports are as active as OH-terminated supports in PROX, (3) hydrogen/water-mediated CO oxidation pathways are active on C3N4-based Au catalysts, and (4) PROX activity requires a rather large porosity (40 nm), which suggests the involvement of much larger intermediates than the usually postulated peroxo-type species.	Water	439-444	pyruvate dehydrogenase complex component X	Homo sapiens	523-527
23130944-1	2012	Aquaporin-2 (AQP2), the vasopressin-regulated water channel of the renal collecting duct, is dysregulated in numerous disorders of water balance in people and animals, including those associated with polyuria (urinary tract obstruction, hypokalemia, inflammation, and lithium toxicity) and with dilutional hyponatremia (syndrome of inappropriate antidiuresis, congestive heart failure, cirrhosis).	Water	46-51	aquaporin 2	Homo sapiens	0-11
23130944-1	2012	Aquaporin-2 (AQP2), the vasopressin-regulated water channel of the renal collecting duct, is dysregulated in numerous disorders of water balance in people and animals, including those associated with polyuria (urinary tract obstruction, hypokalemia, inflammation, and lithium toxicity) and with dilutional hyponatremia (syndrome of inappropriate antidiuresis, congestive heart failure, cirrhosis).	Water	46-51	aquaporin 2	Homo sapiens	13-17
34788052-0	2021	Computational Study Reveals the Role of Water Molecules in the Inhibition Mechanism of LAT1 by 1,2,3-Dithiazoles.	Water	40-45	solute carrier family 7 member 5	Homo sapiens	87-91
23064378-2	2012	The mixture containing 17.8 wt% water successfully dissolved horse heart cytochrome c without significant change of the higher ordered structure.	Water	32-37	cytochrome c, somatic	Equus caballus	73-85
23150480-0	2012	MRSA in waste treatment water poses potential risk.	Water	24-29	solute carrier family 9 member A6	Homo sapiens	0-4
34928963-6	2021	Water stress enhanced peroxidase (POD), catalase (CAT), superoxide dismutase (SOD), polyphenol oxidase (PPO), soluble sugar, malondialdehyde (MDA), proline contents as well as leaf temperature while substantially reduced leaf water contents (21%), stomatal conductance (50%), chlorophyll contents (10-67%), membrane stability index (24%) and grain yield (30%) of canola.	Water	0-5	peroxidase A2	Brassica napus	22-32
34928963-6	2021	Water stress enhanced peroxidase (POD), catalase (CAT), superoxide dismutase (SOD), polyphenol oxidase (PPO), soluble sugar, malondialdehyde (MDA), proline contents as well as leaf temperature while substantially reduced leaf water contents (21%), stomatal conductance (50%), chlorophyll contents (10-67%), membrane stability index (24%) and grain yield (30%) of canola.	Water	0-5	peroxidase A2	Brassica napus	34-37
22988814-5	2012	With increasing ionic concentration, the water contact angles of the Lig-PN increased correspondingly.	Water	41-46	ubiquitin conjugating enzyme E2 K	Homo sapiens	69-72
34977450-3	2021	Catalase in peroxisomes plays an important role in this process by disproportionating H2O2 resulting from glycolate oxidation into O2 and water.	Water	138-143	catalase 2	Arabidopsis thaliana	0-8
23092211-9	2012	Instead, it skews the oxyanion hole and makes the phosphorus more open to the nucleophilic water molecule, resulting in a remarkable change in the rate-determining step and significantly improved catalytic activity of human BChE.	Water	91-96	butyrylcholinesterase	Homo sapiens	224-228
34902875-10	2021	RESULTS:  After water storage for 24 hours, the shear bond strengths were GPU > CCP + SB2 = CTB = OBU = TNU > no Tx (p < 0.05).	Water	16-21	chitobiase	Homo sapiens	92-95
23025527-2	2012	In this work, we have investigated the unfolding of the protein myoglobin (Mb) entrapped in the confinement of the water pool of AOT reverse micelles and in the presence of some commonly used macromolecular crowding agents (Ficoll 70, Dextran 70, and Dextran 40).	Water	115-120	myoglobin	Homo sapiens	64-73
22879379-8	2012	When the dam was exposed to drinking water containing doxycycline (dox), normal endogenous Nmyc expression was rescued, and the embryo survived to birth.	Water	37-42	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	91-95
34945962-0	2021	Thermodynamic Analysis and Optimization of a Novel Power-Water Cogeneration System for Waste Heat Recovery of Gas Turbine.	Water	57-62	gastrin	Homo sapiens	110-113
34945962-1	2021	A power-water cogeneration system based on a supercritical carbon dioxide Brayton cycle (SCBC) and reverse osmosis (RO) unit is proposed and analyzed in this paper to recover the waste heat of a gas turbine.	Water	8-13	gastrin	Homo sapiens	195-198
23209334-5	2012	This suggests the physiological importance of AQP5 in transcellular water transfer.	Water	68-73	aquaporin 5	Homo sapiens	46-50
1635821-8	1992	In addition, plasma gastrin increased significantly in seven infants fed milk compared with eight fed water by orogastric tube (p less than 0.01).	Water	102-107	gastrin	Homo sapiens	20-27
22892540-4	2012	The former undergoes a charge separation reaction yielding [Ca(NH(2))](+) + HCO(+), and the latter undergoes the most favorable Coulomb explosion yielding [Ca-OH](+) + [HCNH](+) and is the origin of a multistep mechanism which accounts for the observed loss of water and HCN.	Water	261-266	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	169-172
1318044-0	1992	Effect of atrial natriuretic factor on the water permeability of endothelial cells.	Water	43-48	natriuretic peptide A	Bos taurus	10-35
1318044-1	1992	Atrial natriuretic factor increases the water permeability of the whole endothelium.	Water	40-45	natriuretic peptide A	Bos taurus	0-25
1318044-9	1992	Hence, atrial natriuretic factor-stimulated increase in water permeability of the endothelium is more related to changes in paracellular water pathways than in transcellular water flux.	Water	56-61	natriuretic peptide A	Bos taurus	7-32
1318044-9	1992	Hence, atrial natriuretic factor-stimulated increase in water permeability of the endothelium is more related to changes in paracellular water pathways than in transcellular water flux.	Water	137-142	natriuretic peptide A	Bos taurus	7-32
34792337-2	2021	The former type A compound has an unfamiliar architecture, even basically comprised of primitive cubic (pcu) topology, and demonstrate porous gas adsorption behavior, giving several hundreds of square meters per gram surface areas after evacuation of the water molecules, while the latter type B compound does not show any porous properties.	Water	255-260	gastrin	Homo sapiens	142-145
23123616-5	2012	Here we show that rapamycin (given in a drinking water) extended the mean lifespan of p53+/- mice by 10% and when treatment started early in life (at the age less than 5 months) by 28%.	Water	49-54	transformation related protein 53, pseudogene	Mus musculus	86-89
34432538-3	2021	In response to stimulation with the antidiuretic hormone, arginine vasopressin, aquaporin-2 containing vesicles fuse with the plasma membrane, which increases collecting duct water reabsorption and thus, urine concentration.	Water	175-180	aquaporin 2	Homo sapiens	80-91
1318044-9	1992	Hence, atrial natriuretic factor-stimulated increase in water permeability of the endothelium is more related to changes in paracellular water pathways than in transcellular water flux.	Water	137-142	natriuretic peptide A	Bos taurus	7-32
1572096-6	1992	In contrast, complement-binding CIC rose substantially only in those rats of both strains displaying EAU in response to S-antigen and not in response to ovalbumin.	Water	101-104	S-antigen visual arrestin	Rattus norvegicus	120-129
22832923-11	2012	On the other hand, 8-mo-long water restriction started at 4 mo old dramatically improved tubular damage and restored once-dampened amount of tubular aquaporin2 protein to the WT level.	Water	29-34	aquaporin 2	Mus musculus	149-159
1284615-5	1992	From these results, it appears that cells bearing receptors for the internal image of the epitope S2, which is not pathogenic when injected emulsified in adjuvants, are able to inhibit S-Ag-induced EAU.	Water	198-201	S-antigen visual arrestin	Rattus norvegicus	185-189
1614996-1	1992	BACKGROUND: Tea from the Camellia sinensis species of the Theaceae family is one of the most ancient and, next to water, the most widely consumed beverage in the world.	Water	114-119	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	12-15
34569134-0	2021	Biomimetic Recognition of Quinones in Water by an Endo-Functionalized Cavity with Anthracene Sidewalls.	Water	38-43	mannosidase endo-alpha	Homo sapiens	50-54
22996817-7	2012	Near-infrared, LIF-detector-compatible MeCy5-OSu was proved suitable for the accurate, sensitive, and rapid separation and determination of aliphatic amines in water and food samples.	Water	160-165	LIF interleukin 6 family cytokine	Homo sapiens	15-18
34615375-1	2021	OBJECTIVE: We measured the turnover rates of the LDLR (low-density lipoprotein receptor) and PCSK9 (proprotein convertase subtilisin/kexin type 9) in mice by metabolic labeling with heavy water and mass spectrometry.	Water	188-193	proprotein convertase subtilisin/kexin type 9	Mus musculus	93-98
34615375-1	2021	OBJECTIVE: We measured the turnover rates of the LDLR (low-density lipoprotein receptor) and PCSK9 (proprotein convertase subtilisin/kexin type 9) in mice by metabolic labeling with heavy water and mass spectrometry.	Water	188-193	proprotein convertase subtilisin/kexin type 9	Mus musculus	100-145
1373524-4	1992	Oocytes from Xenopus laevis microinjected with in vitro-transcribed CHIP28 RNA exhibited increased osmotic water permeability; this was reversibly inhibited by mercuric chloride, a known inhibitor of water channels.	Water	107-112	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	68-74
1373524-5	1992	Therefore it is likely that CHIP28 is a functional unit of membrane water channels.	Water	68-73	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	28-34
22997021-7	2012	Good linearity, accuracy, and precision were obtained and the detection limits were in the range between 0.01 and 0.07 mug mL-1 for river water and 0.17 and 0.37 mug g-1 for soil samples.	Water	138-143	L1 cell adhesion molecule	Mus musculus	123-127
23038722-1	2012	BET 3: In patients with heatstroke is whole-body ice-water immersion the best cooling method?	Water	53-58	trafficking protein particle complex subunit 3	Homo sapiens	0-5
1564422-8	1992	Water intake increased markedly during EGF infusion and was 60% (4 kg) greater on day 4 than that measured during the first saline infusion.	Water	0-5	epidermal growth factor	Mus musculus	39-42
1564422-11	1992	The possibilities that the increased water intake was primary, or secondary, to a diuretic effect of EGF are discussed.	Water	37-42	epidermal growth factor	Mus musculus	101-104
34528858-14	2021	By regulating AQP1 and AQP2, both water retention and toxin accumulation were reduced.	Water	34-39	aquaporin 2	Rattus norvegicus	23-27
22850374-7	2012	Water-soluble chitosan (53 kDa) reduced phiX174, MS2, FCV-F9 and MNV-1 titers by 0.59, 2.44, 3.36, and 0.34 log(10) PFU/ml respectively.	Water	0-5	MS2	Homo sapiens	49-52
34656059-0	2021	Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production.	Water	20-25	reticulon 4	Mus musculus	86-89
11538133-4	1992	Though very cold (averaging about -60 degrees C), highly oxidizing and desiccated, Mars may possess substantial quantities of the materials needed to support life--in particular, water and carbon dioxide.	Water	179-184	methionyl-tRNA synthetase 1	Homo sapiens	83-87
22548241-13	2012	Priming with GM-CSF or TNF-alpha was more effective than IFN-gamma in compensating for the inhibitory PGE(2) effect, since these cytokines induce cells to produce higher H(2)O(2) and TNF-alpha levels.	Water	170-175	colony stimulating factor 2	Homo sapiens	13-19
1535119-7	1992	Suppression of S-antigen-induced EAU was abrogated by pretreatment of donor animals with cyclophosphamide.	Water	33-36	S-antigen visual arrestin	Rattus norvegicus	15-24
34338409-10	2021	This study suggested that SGLT2 inhibitors might reduce body weight by regulating fat mass or water distribution in the body and have cardiac and renal protective effects by resetting the homeostasis of fluid balance.	Water	94-99	solute carrier family 5 member 2	Homo sapiens	26-31
22532286-10	2012	Both hydrotropic stimulation and water stress upregulated the expression of AtATG18a, which is required for autophagosome formation.	Water	33-38	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	76-84
34407909-4	2021	EVIDENCE SYNTHESIS: The EAU has developed a risk-adapted early prostate cancer detection strategy for well-informed men based on PSA testing, risk calculators, and multiparametric magnetic resonance imaging, which can differentiate significant from insignificant prostate cancer.	Water	24-27	kallikrein related peptidase 3	Homo sapiens	129-132
1783013-1	1991	By using a highly specific and sensitive homologous radioimmunoassay, we found that the content of epidermal growth factor (EGF) in the lateral one-third of whole cataractous human lenses (age range 45-85 yr) extracted at elective intracapsular lens surgery, varied from undetectable to 106.25 pg mg-1 water soluble protein (WSP) (mean +/- S.D.	Water	302-307	epidermal growth factor	Homo sapiens	99-122
1783013-1	1991	By using a highly specific and sensitive homologous radioimmunoassay, we found that the content of epidermal growth factor (EGF) in the lateral one-third of whole cataractous human lenses (age range 45-85 yr) extracted at elective intracapsular lens surgery, varied from undetectable to 106.25 pg mg-1 water soluble protein (WSP) (mean +/- S.D.	Water	302-307	epidermal growth factor	Homo sapiens	124-127
23079979-0	2012	Effect  of the IGF-1/PTEN/Akt/FoxO signaling pathway in the duodenal mucosa of rats  subjected to water immersion and restraint stress.	Water	98-103	insulin-like growth factor 1	Rattus norvegicus	15-20
1819731-7	1991	Water-immersion stress affected not only the amount of 1-alkyl-2-acetyl-GPC and 1-acyl-2-acetyl-GPC, but also their molecular heterogeneity in the antrum and corpus.	Water	0-5	glycophorin C	Rattus norvegicus	72-75
1819731-7	1991	Water-immersion stress affected not only the amount of 1-alkyl-2-acetyl-GPC and 1-acyl-2-acetyl-GPC, but also their molecular heterogeneity in the antrum and corpus.	Water	0-5	glycophorin C	Rattus norvegicus	96-99
34857312-3	2021	Roxithromycin has a poor water solubility thus HP-beta-CD is introduced for enhancing drug solubility by forming an inclusion complex in this study.	Water	25-30	adrenocortical dysplasia	Mus musculus	50-57
26605724-0	2012	Determination of Barrier Heights for Proton Exchange in Small Water, Ammonia, and Hydrogen Fluoride Clusters with G4(MP2)-Type, MPn, and SCS-MPn Procedures-A Caveat.	Water	62-67	tryptase pseudogene 1	Homo sapiens	117-120
22739536-7	2012	Water deprivation increased total lysate AQP2 proteins in the inner medulla but had no effect on adenylyl cyclase III, phosphorylated MAPK ERK1/2, and membrane AQP2 proteins in Agtr1a(-/-) mice.	Water	0-5	aquaporin 2	Mus musculus	41-45
34884788-11	2021	On the other hand, B2 can enhance its water absorption ability by increasing the expression of aquaporin genes ZmPIP1-1 and ZmPIP1-5.	Water	38-43	aquaporin PIP1-1	Zea mays	111-119
1838467-1	1991	The function of atrial natriuretic peptide (ANP) is claimed to be control of salt and water homeostasis, and thus, the hormone may be involved in the pathogenesis of certain diseases with impaired volume regulation.	Water	86-91	natriuretic peptide A	Canis lupus familiaris	16-42
1838467-1	1991	The function of atrial natriuretic peptide (ANP) is claimed to be control of salt and water homeostasis, and thus, the hormone may be involved in the pathogenesis of certain diseases with impaired volume regulation.	Water	86-91	natriuretic peptide A	Canis lupus familiaris	44-47
1805282-0	1991	Water and NaCl intake of chicks as mediated by angiotensin II, renin, or salt deficiency.	Water	0-5	renin	Gallus gallus	63-68
21789569-4	2012	It was found that the water-soluble components of the corncob could increase beta-glucosidase production significantly only when mixed with Avicel or wheat bran.	Water	22-27	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1a, chloroplastic	Triticum aestivum	77-93
1953752-6	1991	The four electron transfer from ceruloplasmin to oxygen to form water will prevent peroxide formation at the cell surface.	Water	64-69	ceruloplasmin	Cricetulus griseus	32-45
34792359-1	2021	In this work, we study the water-gas shift (WGS) reaction catalyzed by alpha-MoC(100) supported typical platinum group metal (PGM) single atoms (Rh1, Pd1, and Pt1) and Au1 via density functional theory calculations.	Water	27-32	zinc finger protein 77	Homo sapiens	159-162
21789569-6	2012	On the other hand, the water-insoluble components of the corncob still produced high level of beta-glucosidase (30 IU ml(-1)) although lower than that of using whole corncob.	Water	23-28	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1a, chloroplastic	Triticum aestivum	94-110
1816873-1	1991	We describe a 1 ns molecular dynamics simulation of an 18-residue peptide (corresponding to a portion of the H helix of myoglobin) in water.	Water	134-139	myoglobin	Homo sapiens	120-129
21789569-7	2012	The results suggested that the water-insoluble components of corncob were beneficial for beta-glucosidase production.	Water	31-36	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1a, chloroplastic	Triticum aestivum	89-105
21789569-8	2012	It was further demonstrated that the xylan in the water-insoluble parts of corncob was the important factor in producing beta-glucosidase by A. niger.	Water	50-55	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1a, chloroplastic	Triticum aestivum	121-137
34755729-0	2021	Regulation of aquaporin-3 water permeability by hyaluronan.	Water	26-31	aquaporin 3 (Gill blood group)	Homo sapiens	14-25
22038315-0	2012	Acute effects of a single warm-water bath on serum adiponectin and leptin levels in healthy men: a pilot study.	Water	31-36	leptin	Homo sapiens	67-73
34755729-4	2021	Considering that aquaporin-3 (AQP3) is a protein responsible for transmembrane water transport in the human skin, we have, therefore, investigated the interactions of AQP3 and HA with different molecular weights using molecular dynamics simulations in the present work.	Water	79-84	aquaporin 3 (Gill blood group)	Homo sapiens	17-28
34755729-4	2021	Considering that aquaporin-3 (AQP3) is a protein responsible for transmembrane water transport in the human skin, we have, therefore, investigated the interactions of AQP3 and HA with different molecular weights using molecular dynamics simulations in the present work.	Water	79-84	aquaporin 3 (Gill blood group)	Homo sapiens	30-34
34755729-6	2021	In addition, the permeation rate of water through AQP3 can also be decreased by HA, and this phenomenon is particularly obvious for small molecular HA.	Water	36-41	aquaporin 3 (Gill blood group)	Homo sapiens	50-54
1663797-4	1991	As the molar ratio of gelsolin to actin was increased, the diffusion coefficients of the PLS approached those in pure water while the degree of PLS trapping went to zero.	Water	118-123	gelsolin	Homo sapiens	22-30
22038315-4	2012	Leptin levels significantly increased immediately after WWB with tap water and ISCO(2) (both P &lt; 0.05), and remained significantly higher than those at baseline even 30 minutes after WWB with tap water (P &lt; 0.05).	Water	69-74	leptin	Homo sapiens	0-6
22859853-1	2012	The aquaporin 2 (AQP2) water channel, expressed in kidney collecting ducts, contributes critically to water homeostasis in mammals.	Water	23-28	aquaporin 2	Homo sapiens	4-15
34884463-1	2021	Lens water transport generates a hydrostatic pressure gradient that is regulated by a dual-feedback system that utilizes the mechanosensitive transient receptor potential vanilloid (TRPV) channels, TRPV1 and TRPV4, to sense changes in mechanical tension and extracellular osmolarity.	Water	5-10	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	208-213
22859853-1	2012	The aquaporin 2 (AQP2) water channel, expressed in kidney collecting ducts, contributes critically to water homeostasis in mammals.	Water	23-28	aquaporin 2	Homo sapiens	17-21
1761373-1	1991	Copolymers of acrylated derivatives of alpha-chymotrypsin and polyethylene glycol (PEG) have been prepared and used as biocatalysts for the synthesis of model peptides in organic solvent containing a low quantity of water.	Water	216-221	progestagen associated endometrial protein	Homo sapiens	62-87
22859853-1	2012	The aquaporin 2 (AQP2) water channel, expressed in kidney collecting ducts, contributes critically to water homeostasis in mammals.	Water	102-107	aquaporin 2	Homo sapiens	4-15
22859853-1	2012	The aquaporin 2 (AQP2) water channel, expressed in kidney collecting ducts, contributes critically to water homeostasis in mammals.	Water	102-107	aquaporin 2	Homo sapiens	17-21
34807213-8	2021	The hydrophilic MIP particles can be used as a scavenger to remove ARS from water.	Water	76-81	secreted LY6/PLAUR domain containing 1	Homo sapiens	67-70
22859853-3	2012	Here, we show that AQP2 is not only a water channel but also an integrin-binding membrane protein that promotes cell migration and epithelial morphogenesis.	Water	38-43	aquaporin 2	Homo sapiens	19-23
1770949-1	1991	The steroid-binding capacity of the adrenocortical pregnenolone-binding protein (PBP) is effectively destroyed by extreme temperature (boiling water for 2-5 min); however, the boiled preparation contains a factor that potentiates ligand binding when readded to native PBP.	Water	143-148	phosphatidylethanolamine binding protein 1	Bos taurus	51-79
22799882-9	2012	Using this solid catalyst for the transesterification reaction, high FAME yields were achieved when feedstock oils presented a FFA content until approximately 2% wt/wt and a water content until 2% wt/wt.	Water	174-179	benign adult familial myoclonic epilepsy 1	Homo sapiens	69-73
1770949-1	1991	The steroid-binding capacity of the adrenocortical pregnenolone-binding protein (PBP) is effectively destroyed by extreme temperature (boiling water for 2-5 min); however, the boiled preparation contains a factor that potentiates ligand binding when readded to native PBP.	Water	143-148	phosphatidylethanolamine binding protein 1	Bos taurus	81-84
1948798-4	1991	Mean (SD) twitch Pdi in the three subjects during stimulation with surface electrodes was 19.4 (1.8), 22.5 (1.1), and 29.3 (2.2) cm H2O compared with 12.9 (1.5), 17:4 (1.3), and 22.6 (3.0) cm H2O with needle stimulating electrodes.	Water	132-135	peptidyl arginine deiminase 1	Homo sapiens	17-20
34328901-0	2021	Mix-cultured aerobic denitrifying bacterial communities reduce nitrate: Novel insights in micro-polluted water treatment at lower temperature.	Water	105-110	Mix paired-like homeobox	Homo sapiens	0-3
22782926-2	2012	The impetus for sLe(x) binding to E-selectin is shown to be the high degree of pre-organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture).	Water	185-190	selectin E	Homo sapiens	34-44
34328901-1	2021	Three mix-cultured aerobic denitrifiers were screened from a source water reservoir and named HE1, HE3 and SU4.	Water	68-73	Mix paired-like homeobox	Homo sapiens	6-9
1777966-5	1991	Extraction of saliva with chloroform/methanol/water resulted in 70-90% recovery of PAF.	Water	46-51	PCNA clamp associated factor	Homo sapiens	83-86
22782926-2	2012	The impetus for sLe(x) binding to E-selectin is shown to be the high degree of pre-organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture).	Water	242-247	selectin E	Homo sapiens	34-44
22621967-9	2012	Furthermore, we demonstrated that CA4P cause disruption of microtubules and a weaker apical labeling of pS256-AQP2 in collecting duct principal cells within 1 h. In conclusion, our data indicate that water escapes from the vascular system after CA4P treatment, and it may take place primarily through a renal mechanism.	Water	200-205	aquaporin 2	Rattus norvegicus	104-114
2065906-0	1991	Effect of neuropeptide Y on jejunal water and ion transport in humans.	Water	36-41	neuropeptide Y	Homo sapiens	10-24
34792607-1	2022	Plastid terminal oxidase (PTOX) accepts electrons from plastoquinol to reduce molecular oxygen to water.	Water	98-103	Alternative oxidase family protein	Arabidopsis thaliana	0-24
22776696-7	2012	Combined administration of S. enterica serovar Typhimurium expressing chIFN-alpha and chIL-18 showed markedly enhanced protection compared to single administration of the construct, as determined by mortality, clinical severity, and feed and water intake.	Water	242-247	interleukin 18	Gallus gallus	86-93
34792607-1	2022	Plastid terminal oxidase (PTOX) accepts electrons from plastoquinol to reduce molecular oxygen to water.	Water	98-103	Alternative oxidase family protein	Arabidopsis thaliana	26-30
2065906-2	1991	In animal models of intestinal water and ion transport, neuropeptide Y decreases stimulated secretion but has no consistent effect on basal transport.	Water	31-36	neuropeptide Y	Homo sapiens	56-70
2065906-3	1991	In the present study, the effect of neuropeptide Y on jejunal water and electrolyte transport in healthy volunteers was investigated under basal conditions and during intestinal secretion induced by intraluminal administration of prostaglandin E2.	Water	62-67	neuropeptide Y	Homo sapiens	36-50
2065906-6	1991	Neuropeptide Y significantly increased net absorption of water, sodium, potassium, and chloride under basal conditions.	Water	57-62	neuropeptide Y	Homo sapiens	0-14
2065906-8	1991	The results of the current study suggest that neuropeptide Y can change intestinal water and ion transport from secretion toward absorption.	Water	83-88	neuropeptide Y	Homo sapiens	46-60
34977899-3	2021	The resulting TTF/TTF +@carbon junction (TTF = tetrathiafulvalene) acts as an all-in-one highly stable redox-shuttle/photosensitizer/molecular-catalyst triad for the visible-light-driven water oxidation reaction (WOR) at neutral pH, eliminating the need for metallic or organometallic catalysts and sacrificial electron acceptors.	Water	187-192	ras homolog family member H	Homo sapiens	14-17
34977899-3	2021	The resulting TTF/TTF +@carbon junction (TTF = tetrathiafulvalene) acts as an all-in-one highly stable redox-shuttle/photosensitizer/molecular-catalyst triad for the visible-light-driven water oxidation reaction (WOR) at neutral pH, eliminating the need for metallic or organometallic catalysts and sacrificial electron acceptors.	Water	187-192	ras homolog family member H	Homo sapiens	18-21
34977899-3	2021	The resulting TTF/TTF +@carbon junction (TTF = tetrathiafulvalene) acts as an all-in-one highly stable redox-shuttle/photosensitizer/molecular-catalyst triad for the visible-light-driven water oxidation reaction (WOR) at neutral pH, eliminating the need for metallic or organometallic catalysts and sacrificial electron acceptors.	Water	187-192	ras homolog family member H	Homo sapiens	41-44
1714956-4	1991	Introduction of the cyanoguanidino and N omega-triazolyl moieties into GnRH analogues yielded several water-soluble antagonists which showed a desirable therapeutic ratio (low histamine release activity to high in vivo potency).	Water	102-107	gonadotropin releasing hormone 1	Rattus norvegicus	71-75
22561460-6	2012	In an Escherichia coli pneumonia model, IQGAP1 knockout mice had increased lung weights, lung water, and lung extravascular plasma equivalents of (125)I-labeled albumin compared with wild-type controls.	Water	94-99	IQ motif containing GTPase activating protein 1	Mus musculus	40-46
34977899-4	2021	A water/butyronitrile emulsion was used to physically separate the photoproducts of the WOR, H+ and TTF, allowing the extraction and subsequent reduction of protons in water, and the in situ electrochemical oxidation of TTF to TTF + on carbon in butyronitrile by constant anode potential electrolysis.	Water	2-7	ras homolog family member H	Homo sapiens	100-103
34977899-4	2021	A water/butyronitrile emulsion was used to physically separate the photoproducts of the WOR, H+ and TTF, allowing the extraction and subsequent reduction of protons in water, and the in situ electrochemical oxidation of TTF to TTF + on carbon in butyronitrile by constant anode potential electrolysis.	Water	2-7	ras homolog family member H	Homo sapiens	220-223
34977899-4	2021	A water/butyronitrile emulsion was used to physically separate the photoproducts of the WOR, H+ and TTF, allowing the extraction and subsequent reduction of protons in water, and the in situ electrochemical oxidation of TTF to TTF + on carbon in butyronitrile by constant anode potential electrolysis.	Water	2-7	ras homolog family member H	Homo sapiens	227-230
22950046-5	2012	SOD2, also known as MnSOD, is targeted to mitochondria and is instrumental in regulating ROS by conversion of superoxides to hydrogen peroxide, which is further broken down into H(2)O and oxygen.	Water	178-183	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	0-4
34977899-4	2021	A water/butyronitrile emulsion was used to physically separate the photoproducts of the WOR, H+ and TTF, allowing the extraction and subsequent reduction of protons in water, and the in situ electrochemical oxidation of TTF to TTF + on carbon in butyronitrile by constant anode potential electrolysis.	Water	168-173	ras homolog family member H	Homo sapiens	100-103
1829637-5	1991	With the hydration catalyzed in H2O and analyzed by gas-liquid chromatography, both sweet potato and soybean beta-amylase were found to convert maltal to the beta-anomer of 2-deoxymaltose.	Water	32-35	beta-amylase	Glycine max	109-121
22950046-5	2012	SOD2, also known as MnSOD, is targeted to mitochondria and is instrumental in regulating ROS by conversion of superoxides to hydrogen peroxide, which is further broken down into H(2)O and oxygen.	Water	178-183	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	20-25
22466400-0	2012	Polycyclic aromatic hydrocarbons (PAHs) in the Mediterranean Sea: atmospheric occurrence, deposition and decoupling with settling fluxes in the water column.	Water	144-149	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	61-64
1793747-1	1991	Influence of water solutions of chemically pure adaptogen--synthetic analog of Rhodiola Rosea extract phenol composition (SAR) on functional activity of hemopoietic and tumor cells of mice with Ehrlich ascite cancer was studied in vitro.	Water	13-18	sarcosinemia autosomal recessive	Mus musculus	122-125
2051770-7	1991	NPY at 50 pM/min caused modest absorption and at 500 pM/min yielded a significant proabsorptive effect (P less than 0.05) for H2O, Na+, and Cl- during the drug infusion period.	Water	126-129	neuropeptide Y	Homo sapiens	0-3
34118630-1	2021	The efforts of this study aimed to evaluate the feasibility of the nanotubular halloysites in weathered pegmatites (NaHWP) for removing heavy metals (i.e., Cd2+, Pb2+) from water.	Water	173-178	CD2 molecule	Homo sapiens	156-159
34118630-2	2021	Furthermore, two novel intelligent models, such as teaching-learning-based optimization (TLBO)-artificial neural network (ANN), and TLBO-support vector regression (SVR), named as TLBO-ANN and TLBO-SVR models, respectively, were proposed to predict the Cd2+ and Pb2+ absorption efficiencies from water using the NaHWP absorbent.	Water	295-300	CD2 molecule	Homo sapiens	252-255
34118630-3	2021	Databases used, including 53 experiments for Pb2+ absorption and 56 experiments for Cd2+ absorption from water, under the catalysis of different conditions, such as initial concentration of Pb2+ and Cd2+, solution pH, adsorbent weight, and contact time.	Water	105-110	CD2 molecule	Homo sapiens	84-87
2051770-9	1991	These data demonstrate a significant proabsorptive effect of NPY on water and electrolyte transport in the isolated perfused ileum.	Water	68-73	neuropeptide Y	Homo sapiens	61-64
21733236-5	2012	Specifically, rats microinfused with aggregated Abeta25-35 (10 mug/side) into bilateral CA1 subregions displayed deficits in learning ability and memory, as evidenced by decreases in escape latency during acquisition trials and exploratory activities in the probe trial in the water-maze task and 24-h retention in the passive avoidance test.	Water	277-282	carbonic anhydrase 1	Rattus norvegicus	88-91
1823188-6	1991	Similarly, for bovine insulin the chemical shifts in a trifluoroethanol/water solvent mixture are comparable to those observed in acetonitrile/water.	Water	72-77	insulin	Bos taurus	22-29
1866378-2	1991	The use of a 30/70 mixture of trichlorofluoromethane (P11) and dichlorodifluoromethane (P12) resulted in the formation of stable, isotropic systems containing 0.5-2.0% (w/v) SPC and solubilized water; R (moles water/moles SPC), 0.9 to 4.28.	Water	194-199	endonuclease, poly(U) specific	Homo sapiens	54-57
34118630-4	2021	Subsequently, the TLBO-ANN and TLBO-SVR models were developed and applied to predict the efficiencies of Cd2+ and Pb2+ absorption from water, aiming to evaluate the role as well as the effects of different conditions on the absorption efficiencies using the NaHWP absorbent.	Water	135-140	CD2 molecule	Homo sapiens	105-108
34118630-7	2021	The two novel hybrid models proposed, i.e., TLBO-ANN and TLBO-SVR, also yielded the dominant performances and accuracies in predicting the Cd2+ and Pb2+ absorption efficiencies from water, i.e., RMSE = 1.190 and 1.102, R2 = 0.951 and 0.957, VAF = 94.436 and 95.028 for the TLBO-ANN and TLBO-SVR models, respectively, in predicting the Pb2+ absorption efficiency from water; RMSE = 3.084 and 3.442, R2 = 0.971 and 0.965, VAF = 96.499 and 96.415 for the TLBO-ANN and TLBO-SVR models, respectively, in predicting the Cd2+ absorption efficiency from water.	Water	182-187	CD2 molecule	Homo sapiens	139-142
34118630-8	2021	Furthermore, the validation results also demonstrated these findings in practice through 23 experiments with the accuracies of 98.3% and 98.37% for the TLBO-ANN and TLBO-SVR models, respectively, in predicting the Pb2+ absorption efficiency from water; the accuracies of 98.3% and 97.46% for the TLBO-ANN and TLBO-SVR models, respectively, in predicting the Cd2+ absorption efficiency from water.	Water	390-395	CD2 molecule	Homo sapiens	358-361
1910746-5	1991	Sea-water values confirmed the results of biological material thus testifying a particularly interesting environmental condition due to low contamination level detected in this part of the coast.	Water	4-9	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
22587901-1	2012	A binary BiTe nanocompound for thermoelectric applications was prepared via a water-based chemical reaction under atmospheric conditions.	Water	78-83	centrosomal protein 70	Homo sapiens	9-13
34097214-1	2021	This paper presents an experimental study on continuous adsorptive removal of Cd2+ from the water body using a bio-nanocomposite hydrogel within a fixed-bed column (FBC) system.	Water	92-97	CD2 molecule	Homo sapiens	78-81
22686136-2	2012	The aggregated structures of MTNa and MPNa in water were investigated, employing several independent methods.	Water	46-51	methylthioribose-1-phosphate isomerase 1	Homo sapiens	29-33
34790111-6	2021	In the Morris water maze, cognitive impairment was more pronounced in 12-month-old UL122 mice than in 6-month-old ones.	Water	14-19	regulatory protein IE2	Human betaherpesvirus 5	83-88
34211154-0	2021	Aquaporin 2 regulation: implications for water balance and polycystic kidney diseases.	Water	41-46	aquaporin 2	Homo sapiens	0-11
34211154-1	2021	Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is essential for the maintenance of mammalian water homeostasis.	Water	132-137	aquaporin 2	Homo sapiens	30-55
34211154-1	2021	Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is essential for the maintenance of mammalian water homeostasis.	Water	132-137	aquaporin 2	Homo sapiens	57-61
34671157-3	2021	Here we report the multiplexed selectivity of dorsal CA1 neurons while rats performed a virtual navigation task using only distal visual cues5, similar to the standard water maze test of spatial memory1.	Water	168-173	carbonic anhydrase 1	Rattus norvegicus	53-56
34778648-8	2021	When the atomic nitrogen gas generated by the PbDBD was sprayed onto the surface of the water phase and subsequently reacted as a plasma/liquid interfacial reaction, the nitrogen fixation rate increased by 7.26-fold compared to that when using the discharge without dielectric beads, and the ammonia production selectivity increased to 83.7%.	Water	88-93	gastrin	Homo sapiens	25-28
34771902-9	2021	With the increase of the amount of trifluoromethyl, the water absorption of PAI material decreased and the water contact angle increased, which indicated that the hydrophobic property of PAI material was improved.	Water	56-61	serpin family E member 1	Homo sapiens	76-79
34771902-9	2021	With the increase of the amount of trifluoromethyl, the water absorption of PAI material decreased and the water contact angle increased, which indicated that the hydrophobic property of PAI material was improved.	Water	56-61	serpin family E member 1	Homo sapiens	187-190
34771902-9	2021	With the increase of the amount of trifluoromethyl, the water absorption of PAI material decreased and the water contact angle increased, which indicated that the hydrophobic property of PAI material was improved.	Water	107-112	serpin family E member 1	Homo sapiens	187-190
34771902-10	2021	To sum up, the results of this study showed that the introduction of trifluoromethyl into the side chain provided an effective way to prepare PAI materials with low water absorption.	Water	165-170	serpin family E member 1	Homo sapiens	142-145
34771921-6	2021	The sample containing 7.5% Cat-Chit polymer in water (CPW) exhibited the highest compressive strength, and its 28-day compressive strength was ~20.2% higher than that of a control sample with no added polymer.	Water	47-52	chitinase 1	Homo sapiens	31-35
34833365-5	2021	Results: The results showed that DPL administration significantly improved certain reduced fecal parameters (number, weight, and water content of the stools) in a both low-fiber diet and loperamide-induced constipation models without adverse effects of diarrhea.	Water	129-134	prion like protein doppel	Mus musculus	33-36
34636529-2	2021	At process times above 150 s, the oversupplied KF agglomerated into large islands and was subsequently eliminated during the deposition of the chemical bath deposition (CBD)-Zn(O,S) buffer layer owing to the islands" water-soluble characteristics.	Water	217-222	arylformamidase	Homo sapiens	47-49
34339635-9	2021	Combined with our previous finding of a 10-fold increase in the ordering of water when fully hydrated elastin fibers are stretched by 50%, these results support the hypothesis that stretch induced solvent ordering, i.e., the hydrophobic effect, is a key player in the elastic recoil of elastin as opposed to configurational entropy loss.	Water	76-81	elastin	Bos taurus	102-109
34339635-9	2021	Combined with our previous finding of a 10-fold increase in the ordering of water when fully hydrated elastin fibers are stretched by 50%, these results support the hypothesis that stretch induced solvent ordering, i.e., the hydrophobic effect, is a key player in the elastic recoil of elastin as opposed to configurational entropy loss.	Water	76-81	elastin	Bos taurus	286-293
34558579-1	2021	Expanding the family of lanthanide terpyridine coordination polymers has yielded eighteen new complexes with two different phases, Ln(TPC)2(HCOO)(H2O) (Ln-1) and Ln(TPC)(HCOO)2 (Ln-2) (Ln = Sm-Lu, except Tm).	Water	146-149	two pore segment channel 2	Homo sapiens	131-139
34657212-5	2021	The detection limit (1.10 ng mL-1) was lower than the maximum permissible Hg2+ levels in drinking water set by the World Health Organization (6 ng mL-1) and U.S. Environmental Protection Agency (2 ng mL-1).	Water	98-103	L1 cell adhesion molecule	Mus musculus	147-151
34339711-7	2021	In the water maze, NF1 Het PC, but not MC, mice showed reduced cognitive flexibility and impaired ability to locate the third hidden platform location, which was improved by Alk inhibition (3.6 mg/kg).	Water	7-12	neurofibromin 1	Mus musculus	19-22
34339711-7	2021	In the water maze, NF1 Het PC, but not MC, mice showed reduced cognitive flexibility and impaired ability to locate the third hidden platform location, which was improved by Alk inhibition (3.6 mg/kg).	Water	7-12	anaplastic lymphoma kinase	Mus musculus	174-177
34426395-7	2021	These findings have important implications for wastewater treatment to transform the forestry waste into a valuable adsorbent for Cd2+ removal from water.	Water	148-153	CD2 molecule	Homo sapiens	130-133
34643874-1	2021	In this work, we synthesized new Schiff base of benzoxazine derivatives in excellent yields using multicomponent reactions of phthalaldehyde or its derivatives, primary amines, isothiocyanate, 2,4-dihydroxyacetophenone, isopropenylacetylene and methyl or ethyl amine in the presence of catalytic amount of Cu/KF/CP@MWCNTs NCs in water at room temperature.	Water	329-334	arylformamidase	Homo sapiens	309-311
34643874-2	2021	Also, the catalytic activity of the green synthesized Cu/KF/CP@MWCNTs NCs was evaluated in the reduction in organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions.	Water	159-164	arylformamidase	Homo sapiens	57-59
1910018-2	1991	During the recrystallization of the crude protected tripeptide ester Moz-Asn-Leu-Gly-OEt (obtained by an enzymatic coupling reaction) in methanol/water, the transesterification of this compound to methyl ester was observed.	Water	146-151	lysine acetyltransferase 6A	Homo sapiens	69-72
1910018-3	1991	The involvement of Ca2+ in this process was indicated by the results obtained in the following experiments: 1) incubation of crude Moz-Asn-Leu-Gly-OEt in methanol solutions of o-phenanthroline and EDTA; 2) recrystallization of the crude Moz-Asn-Leu-Gly-OEt in ethanol/water followed by incubation in methanol; 3) determination of the Ca2+ content of the crude Moz-Asn-Leu-Gly-OEt.	Water	268-273	lysine acetyltransferase 6A	Homo sapiens	131-134
1712069-3	1991	Free SH groups may be generated at these alpha 2M residues through the action of proteinases, amines such as methylamine, or at a slow rate, by H2O ("aging" of alpha 2M).	Water	144-147	alpha-2-macroglobulin	Homo sapiens	160-168
1829866-1	1991	Atrial natriuretic peptide has been considered to be a major regulator in the body"s water and salt homeostasis.	Water	85-90	natriuretic peptide A	Canis lupus familiaris	0-26
2062213-4	1991	The results underscore the dominant role of total water content W in the relaxation process and verify the expected linearity between 1/T1 and 1/W.	Water	50-55	CD5 molecule	Homo sapiens	136-144
2026719-7	1991	Hydrolysis of styrene oxide treated hemoglobin in 18O-labeled water revealed at least two mechanisms of ester hydrolysis, including the BAL 1 pathway.	Water	62-67	poly(ADP-ribose) polymerase family member 9	Homo sapiens	136-141
2053519-5	1991	Pretreatment with histamine H2 receptor antagonist cimetidine significantly reduced the extravasation of both the tracers and thwarted the increase of brain water content as compared to the untreated group.	Water	157-162	histamine receptor H 2	Rattus norvegicus	18-39
1702408-5	1990	Furthermore, transfer of Ts cells from S-antigen-immunized and FK506-treated rats to naive syngenic rats induced partial inhibition of EAU induction or delay of EAU onset after immunizing the recipient rats with S-antigen.	Water	135-138	S-antigen visual arrestin	Rattus norvegicus	39-48
1702408-5	1990	Furthermore, transfer of Ts cells from S-antigen-immunized and FK506-treated rats to naive syngenic rats induced partial inhibition of EAU induction or delay of EAU onset after immunizing the recipient rats with S-antigen.	Water	161-164	S-antigen visual arrestin	Rattus norvegicus	39-48
2231727-5	1990	The refined model includes residues 2 to 108, three Ca2+ and 87 water molecules per oncomodulin molecule.	Water	64-69	oncomodulin	Rattus norvegicus	84-95
2231727-11	1990	The third Ca2+ is also seven-co-ordinated, to five oxygen atoms belonging to three different oncomodulin molecules and to two water molecules which form hydrogen bonds to a fourth oncomodulin; thus, this intermolecular Ca2+ and its equivalents interlink the molecules into zigzag layers normal to the b axis with a spacing of b/2 or 32.14 A.	Water	126-131	oncomodulin	Rattus norvegicus	180-191
18595117-1	1990	A lipoprotein lipase (LPL) was made water insoluble by immobilizing onto the surface of polyacrolein (PAA) microspheres with and without oligoglycines as spacer.	Water	36-41	lipoprotein lipase	Homo sapiens	2-20
18595117-1	1990	A lipoprotein lipase (LPL) was made water insoluble by immobilizing onto the surface of polyacrolein (PAA) microspheres with and without oligoglycines as spacer.	Water	36-41	lipoprotein lipase	Homo sapiens	22-25
2205696-2	1990	Postprandial hyperinsulinemia was produced by feeding young ferrets glucose/water and a regular diet (glucose-treated group), as reflected by the mean serum insulin levels attained, which were 57 and 135 microU/ml during control and postinfluenza periods, respectively.	Water	76-81	insulin	Mustela putorius furo	18-25
2205696-3	1990	By comparison, ferrets fed water and a regular diet (untreated group) had mean insulin levels of 19 and 22 microU/ml, while postprandial glucose levels were comparable in the two groups of animals for each period.	Water	27-32	insulin	Mustela putorius furo	79-86
2171047-4	1990	The immunohistochemical analysis revealed discrete localization of DBI-LI in cell types with specialized functions: for example, the highest DBI-LI content was found in steroid-producing cells (glomerulosa and fasciculata cells of adrenal cortex, Leydig cells of testis); lower DBI-LI immunostaining was found in epithelial cells specialized for water and electrolyte transport (intestinal mucosa, distal convoluted tubules of kidney).	Water	346-351	diazepam binding inhibitor	Rattus norvegicus	67-70
2171047-4	1990	The immunohistochemical analysis revealed discrete localization of DBI-LI in cell types with specialized functions: for example, the highest DBI-LI content was found in steroid-producing cells (glomerulosa and fasciculata cells of adrenal cortex, Leydig cells of testis); lower DBI-LI immunostaining was found in epithelial cells specialized for water and electrolyte transport (intestinal mucosa, distal convoluted tubules of kidney).	Water	346-351	diazepam binding inhibitor	Rattus norvegicus	141-144
2171047-4	1990	The immunohistochemical analysis revealed discrete localization of DBI-LI in cell types with specialized functions: for example, the highest DBI-LI content was found in steroid-producing cells (glomerulosa and fasciculata cells of adrenal cortex, Leydig cells of testis); lower DBI-LI immunostaining was found in epithelial cells specialized for water and electrolyte transport (intestinal mucosa, distal convoluted tubules of kidney).	Water	346-351	diazepam binding inhibitor	Rattus norvegicus	141-144
2166170-7	1990	In total, five water molecules occupy conserved positions in the structures of horse heart, yeast iso-1, tuna and rice cytochromes c. Three of these are on the surface of the protein, serving to stabilize local polypeptide chain conformations.	Water	15-20	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	98-103
2166170-11	1990	It is shown that this latter water molecule shifts in a consistent manner upon change in oxidation state if cytochrome c structures from various sources are compared.	Water	29-34	cytochrome c, somatic	Equus caballus	108-120
2166170-12	1990	The conservation of this structural feature and its close proximity to the heme iron atom strongly implicate this internal water molecule as having a functional role in the mechanism of action of cytochrome c.	Water	123-128	cytochrome c, somatic	Equus caballus	196-208
2347727-5	1990	The specific dose constant in water was determined to be 0.932 (1.184 cGy-cm2/mCi-h, for the conventional exposure rate constant of 1.45 R cm2/mCi-h).	Water	30-35	multiciliate differentiation and DNA synthesis associated cell cycle protein	Mus musculus	78-81
2347727-5	1990	The specific dose constant in water was determined to be 0.932 (1.184 cGy-cm2/mCi-h, for the conventional exposure rate constant of 1.45 R cm2/mCi-h).	Water	30-35	multiciliate differentiation and DNA synthesis associated cell cycle protein	Mus musculus	143-146
2142376-5	1990	Treatment of surface-bound 125I-IL-1 alpha with a bivalent water-soluble cross-linker identified a membrane peptide of Mr 70,000 cross-linked to IL-1.	Water	59-64	interleukin 1 alpha	Mus musculus	32-42
2218100-5	1990	At lung volumes below FRC, twitch Pdi increased by 12.4 +/- 8.6 cm H2O per litre of volume change.	Water	67-70	peptidyl arginine deiminase 1	Homo sapiens	34-37
2353025-0	1990	1,4-Dihydronaphthoquinones as water-soluble inhibitors of 5-lipoxygenase.	Water	30-35	arachidonate 5-lipoxygenase	Rattus norvegicus	58-72
2298731-4	1990	The results indicated that acidic lipids form a water-soluble complex with glucosylceramidase but not with saposins and that saposins and acidic lipids each bind to the enzyme at two different sites for the activation.	Water	48-53	glucosylceramidase beta	Homo sapiens	75-93
31003365-5	1990	Strains that produced enterotoxin were isolated from 5 (6%) of the 80 food handlers tested, from 2 (2%) of the 106 dogs, from 5 (12%) of the 41 oysters, and from 2 (10%) of the 20 samples of water.	Water	191-196	cpe	Clostridium perfringens	22-33
2168664-7	1990	Infusion of CSF only led to an increase in water content from 69 to between 75% and 79%.	Water	43-48	granulocyte-macrophage colony-stimulating factor	Felis catus	12-15
34624042-1	2021	Previously we have shown that trypsin, a protein typically involved in digestion, is released from gills of both fresh and saltwater fishes into surrounding water under stress or injury.	Water	157-162	serine protease 1	Danio rerio	30-37
34553718-0	2021	Janus PtXO (X = S, Se) monolayers: the visible light driven water splitting photocatalysts with high carrier mobilities.	Water	60-65	squalene epoxidase	Homo sapiens	19-21
26285732-2	2012	The metal-to-ligand charge-transfer luminescence from Ru-dppz is efficient in the presence of CPD because the complex is shielded from water by binding to the hydrophobic dendrimer core.	Water	135-140	carboxypeptidase D	Homo sapiens	94-97
34849123-13	2021	The predominance of TIMP-1 over MMP-1 in blood serum can potentially limit TEWL and maintain the proper water content of the epidermis.	Water	104-109	matrix metallopeptidase 1	Homo sapiens	32-37
23003928-3	2012	The ground-state quantum coherence and Rabi oscillations of the SMM V15 ([V15(IV)As6(III)O42(H2O)]6-) have been studied in this context.	Water	93-96	immunoglobulin lambda variable 2-18	Homo sapiens	68-71
34588880-7	2021	It was observed that the level of cytokines pro-inflammatory (IL-17, IL-6, IL-2, IL-4, INF-gamma) in serum was normalized in mice treated with ICE, which would indicate that polyP prevents the local inflammatory response in the respiratory tract.	Water	143-146	interleukin 2	Mus musculus	75-79
34588880-7	2021	It was observed that the level of cytokines pro-inflammatory (IL-17, IL-6, IL-2, IL-4, INF-gamma) in serum was normalized in mice treated with ICE, which would indicate that polyP prevents the local inflammatory response in the respiratory tract.	Water	143-146	interleukin 4	Mus musculus	81-85
2111763-1	1990	Two tissue-specific water-soluble antigens AG1 and AG2 are revealed in immunobiochemical analysis of human squamous epithelium extract.	Water	20-25	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	51-54
2107177-5	1990	However, using the same C-18 column but with a mobile phase of H2O-IPA-MeCN (80 + 12 + 8) (MP-B), the M2a peak exhibited 25,000 plates when injected in 30% aqueous MeCN and 10,000 plates when injected in water alone.	Water	204-209	AFA1	Homo sapiens	91-95
22419689-1	2012	Urine concentration involves the hormone vasopressin (AVP), which stimulates cAMP production in renal principal cells, resulting in translocation and transcription of aquaporin-2 (AQP2) water channels, greatly increasing the water permeability, leading to a concentrated urine.	Water	186-191	aquaporin 2	Mus musculus	167-178
2298835-1	1990	Eight healthy right-handed young men were subjected to local CBF measurement by [15O]water and positron emission tomography during partial sensory deprivation and during sensory-cognitive activation; physiological, hormonal, and subjective stress measurements were also performed.	Water	85-90	CCAAT enhancer binding protein zeta	Homo sapiens	61-64
34903939-1	2021	Background and Aim: Aquaporin-2 (AQP2) and arginine vasopressin receptor-2 (AVPR2) are proteins that control water homeostasis in principal cells.	Water	109-114	aquaporin 2	Canis lupus familiaris	20-31
34903939-1	2021	Background and Aim: Aquaporin-2 (AQP2) and arginine vasopressin receptor-2 (AVPR2) are proteins that control water homeostasis in principal cells.	Water	109-114	aquaporin 2	Canis lupus familiaris	33-37
22419689-1	2012	Urine concentration involves the hormone vasopressin (AVP), which stimulates cAMP production in renal principal cells, resulting in translocation and transcription of aquaporin-2 (AQP2) water channels, greatly increasing the water permeability, leading to a concentrated urine.	Water	186-191	aquaporin 2	Mus musculus	180-184
34903939-12	2021	The central role of specific AQP2 and AVPR2 in regulating water homeostasis will provide correlations in case of CKD with polyuria.	Water	58-63	aquaporin 2	Canis lupus familiaris	29-33
22419689-1	2012	Urine concentration involves the hormone vasopressin (AVP), which stimulates cAMP production in renal principal cells, resulting in translocation and transcription of aquaporin-2 (AQP2) water channels, greatly increasing the water permeability, leading to a concentrated urine.	Water	225-230	aquaporin 2	Mus musculus	167-178
33765576-5	2021	The proposed pilot Red Sea - Dead Sea project (RSDSP) is to desalinate seawater from the Gulf of Aqaba/Eilat and convey the reject brine, with or without additional seawater, to the Dead Sea to slow down the rate of its water level decline.	Water	74-79	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	23-26
33765576-5	2021	The proposed pilot Red Sea - Dead Sea project (RSDSP) is to desalinate seawater from the Gulf of Aqaba/Eilat and convey the reject brine, with or without additional seawater, to the Dead Sea to slow down the rate of its water level decline.	Water	74-79	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	34-37
22419689-1	2012	Urine concentration involves the hormone vasopressin (AVP), which stimulates cAMP production in renal principal cells, resulting in translocation and transcription of aquaporin-2 (AQP2) water channels, greatly increasing the water permeability, leading to a concentrated urine.	Water	225-230	aquaporin 2	Mus musculus	180-184
33765576-8	2021	In a large-scale project, if this gypsum remains in suspension, it may result in increased turbidity and whitening of the Dead Sea"s surface water, thereby impacting the lake"s appearance, its energy balance, and its touristic and mineral industries.	Water	141-146	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	127-130
22402263-5	2012	This paper aims to review the different processes and treatments that have been applied for the elimination of E1, E2, E3 and EE2 from water.	Water	135-140	small nucleolar RNA, H/ACA box 73A	Homo sapiens	111-121
33798824-5	2021	In this study, we investigated the effect of the simultaneous exposure of Cd2+ and nano Fe2O3 on conjugative transfer of plasmid RP4 from Pseudomonas putida KT2442 to water microbial community.	Water	167-172	CD2 molecule	Homo sapiens	74-77
34681089-15	2021	ST1 and ST3 were most common in water samples.	Water	32-37	syndecan binding protein	Homo sapiens	0-3
34681089-15	2021	ST1 and ST3 were most common in water samples.	Water	32-37	tumor-suppressor, HELA cell type	Homo sapiens	8-11
34681089-16	2021	ST1, ST2, ST3, ST4, ST5 and ST6 were shared by humans, animals, and water sources.	Water	68-73	syndecan binding protein	Homo sapiens	0-3
22153591-2	2012	The main contribution of radionuclides in the SCC process water discharged into the Tom River was from the single-pass reactors, now removed from service (the last SCC reactor was shutdown on June 5, 2008).	Water	58-63	pre-mRNA processing factor 6	Homo sapiens	84-87
33773709-4	2021	In this work, DyOH was selected as fluorophore scaffolds to synthesize probe Hex-1 for detection of Hexs with good water solubility, high specificity, large stokes shift and quick response.	Water	115-120	exonuclease 1	Homo sapiens	77-82
33773733-5	2021	The limit of detection (at a signal-to-noise ratio of 3) were in the range 2-20 ng mL-1 for tap water and black tea drinks, 0.2-2 mug g-1 for honey.	Water	96-101	L1 cell adhesion molecule	Mus musculus	83-87
22503289-6	2012	We observed an 85% survival rate of Nags(-/-) mice when they were given intraperitoneal injections with NCG and Cit during the newborn period until weaning and supplemented subsequently with both compounds in their drinking water.	Water	224-229	N-acetylglutamate synthase	Mus musculus	36-40
33973366-5	2021	The 1 O 2 generating rate of Ir-1 in EtOH/water mixture solution is 2.3 times higher than that of Rose Bengal.	Water	42-47	nischarin	Homo sapiens	29-33
34679648-5	2021	A high-fat diet established the model of lipid metabolism disorder in premature aging SAMP8 mice, and these mice were gavaged different tea water extracts.	Water	140-145	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	136-139
34564668-9	2021	A water molecule was hydrogen-bonded to residues Thr9 and Ser 11, as reported for the yeast Gtt2, suggesting a primary role in the reaction.	Water	2-7	glutathione transferase GTT2	Saccharomyces cerevisiae S288C	92-96
22490881-1	2012	The membrane-bound water channel aquaporin-4 plays a significant role in the regulation of water movement within the retina.	Water	19-24	aquaporin 4	Rattus norvegicus	33-44
34564668-13	2021	VpGSTT2 was the first bacterial Gtt2 characterized, in which residues Ser11 and Thr9 coordinated a water molecule as part of a catalytic mechanism that was characteristic of yeast GTT2.	Water	99-104	glutathione transferase GTT2	Saccharomyces cerevisiae S288C	32-36
34564668-13	2021	VpGSTT2 was the first bacterial Gtt2 characterized, in which residues Ser11 and Thr9 coordinated a water molecule as part of a catalytic mechanism that was characteristic of yeast GTT2.	Water	99-104	glutathione transferase GTT2	Saccharomyces cerevisiae S288C	180-184
33825451-2	2021	Herein, a small activated carbon electrode tip is employed as solid support to preconcentrate heavy metals in water and subsequently served as an inner electrode of the coaxial dielectric barrier discharge (DBD) to generate microplasma.	Water	110-115	TOR signaling pathway regulator	Homo sapiens	43-46
33825451-3	2021	In this case, heavy metal analytes in water are first adsorbed on the surface of the activated carbon electrode tip via a simple liquid-solid phase transformation during the sample loading process, and then, fast released to produce OES during the DBD microplasma excitation process.	Water	38-43	TOR signaling pathway regulator	Homo sapiens	112-115
22490881-1	2012	The membrane-bound water channel aquaporin-4 plays a significant role in the regulation of water movement within the retina.	Water	91-96	aquaporin 4	Rattus norvegicus	33-44
33825451-6	2021	With a multiplexed activated carbon electrode tip array, a batch of water samples (50 mL) can be loaded in parallel within 5 min.	Water	68-73	TOR signaling pathway regulator	Homo sapiens	10-13
22410625-6	2012	The model indicates that PCBs in the Adriatic Sea are closely coupled with the atmosphere, which acts as a net source to the water column.	Water	125-130	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	46-49
33762731-7	2021	Within the ligand-binding pocket of apo-5-HT1A are structured water molecules that mimic 5-HT to activate the receptor.	Water	62-67	5-hydroxytryptamine receptor 1A	Homo sapiens	40-46
34491037-1	2021	The dynamics and structure of water in polyacrylamide hydrogels (PAAm-HG), polyacrylamide, and acrylamide solutions are investigated using ultrafast infrared experiments on the OD stretch of dilute HOD/H2O and molecular dynamics simulations.	Water	30-35	HOP homeobox	Homo sapiens	198-201
34491037-1	2021	The dynamics and structure of water in polyacrylamide hydrogels (PAAm-HG), polyacrylamide, and acrylamide solutions are investigated using ultrafast infrared experiments on the OD stretch of dilute HOD/H2O and molecular dynamics simulations.	Water	202-205	HOP homeobox	Homo sapiens	198-201
22435987-4	2012	A meta-analysis of 317 species from 72 studies showed that pi(tlp) was strongly correlated with water availability within and across biomes, indicating power for anticipating drought responses.	Water	96-101	cysteine rich protein 3	Homo sapiens	62-65
33798575-1	2021	In this study, an active component UP1-1 was isolated from Chinese Huangshan Umbilicaria esculenta via hot water extraction and purified by anion-exchange and gel-filtration chromatography.	Water	107-112	major urinary protein 1	Mus musculus	35-40
33806238-7	2021	The number of infiltrating COX-1 positive cells correlated with the severity of EAU.	Water	80-83	prostaglandin-endoperoxide synthase 1	Mus musculus	27-32
22368250-0	2012	A possibility of a protein-bound water molecule as the ionizable group responsible for pKe at the alkaline side in human matrix metalloproteinase 7 activity.	Water	33-38	matrix metallopeptidase 7	Homo sapiens	121-147
33802638-6	2021	Among the Carmenere pomace extracts analyzed in this study, 1000 microg/mL of the water-ethanol extract obtained, at 90  C, reduced differentially the alpha-amylase (56%) and alpha-glucosidase (98%) activities.	Water	82-87	alpha-amylase	Vitis vinifera	151-164
34111746-9	2021	The fabricated PM/g-C3N4/ASPE sensor exhibits superior stability, repeatability, good anti-interference, and applicability for recognition of Pb2+ and Cd2+ ions in real water samples.	Water	169-174	CD2 molecule	Homo sapiens	151-154
22415292-0	2012	Myoglobin-directed assemblies of binary monolayers functionalized with iminodiacetic acid ligands at the air-water interface through metal coordination for multivalent protein binding.	Water	109-114	myoglobin	Homo sapiens	0-9
34612437-1	2021	Using MP2, CCSD(T) electronic structure theory and ab initio molecular dynamics simulations, we explore the structure, solvation dynamics and vibrational spectra of OH-(H2O)n clusters.	Water	169-172	tryptase pseudogene 1	Homo sapiens	6-9
34612437-3	2021	In the case of OH-(H2O)26, we show that MP2 and CCSD(T) calculations predict global minima structures with the hydroxide ion occupying the interior region of a densely packed cubic cluster that is secured by ionic hydrogen bonds.	Water	19-22	tryptase pseudogene 1	Homo sapiens	40-43
33763048-7	2021	Our results suggested that estuarine output had a great influence on the Bohai Sea environment and changes in the water environmental conditions caused by estuarine output developed distinctive microbial communities in the middle of the Bohai Sea.	Water	114-119	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	243-246
22415292-1	2012	Myoglobin binding to the binary monolayers composed of sodium hexadecylimino diacetate and hexadecanol at the air-water interface by means of metal coordination has been investigated using infrared reflection absorption spectroscopy (IRRAS).	Water	114-119	myoglobin	Homo sapiens	0-9
22395315-5	2012	In organotypic cultures of skin, EGF acted to impair epidermal barrier integrity, as shown by increased transepidermal water loss.	Water	119-124	epidermal growth factor	Homo sapiens	33-36
34514597-0	2022	Free-Phase Gas Detection in Groundwater Wells via Water Pressure and Continuous Field Parameters.	Water	50-55	gastrin	Homo sapiens	11-14
22244971-2	2012	The turbidity of permeate water was &lt;0.2 NTU for both T300 and T0.05-450 suspensions in the MPR system operated at different transmembrane pressures (TMPs) and cross-flow velocities (CFVs), indicating effective separation of TiO(2) particles by the MF membrane.	Water	26-31	progesterone receptor membrane component 1	Homo sapiens	95-98
34450001-7	2021	Quantitative assessment of AWC-PA membranes shows that water permeability increases roughly from 2.09 to 3.85 L m-2 h-1 bar-1, for HC4 and HC6 reverse osmosis membranes, respectively, while maintaining excellent NaCl rejection (99.25-99.51%).	Water	55-60	CYCS pseudogene 52	Homo sapiens	139-142
22444298-8	2012	Similar surface tension values for Mb in water and in Phe-IL suggests that direct ion binding interactions with the protein coupled with the change in local viscosity from the IL seems to not only alter the secondary structure of individual proteins but also drives the self-assembly of the protein molecules leading finally to fibril formation.	Water	41-46	myoglobin	Homo sapiens	35-37
34500846-1	2021	In this study, a new method for selective determination of Cr(VI) in water samples at pH 4 is presented using raffinose capped silver nanoparticles (Ag/Raff NPs) as an optical sensor.	Water	69-74	prolyl 4-hydroxylase, transmembrane	Homo sapiens	86-90
22496554-9	2012	Finally, Psen1 c.548G>T(KI/KI);Psen2(-/-) mice exhibited mild spatial memory deficits in the Morris water maze task.	Water	100-105	presenilin 1	Mus musculus	9-14
34161607-0	2021	Spectroscopic Analysis of Apoferritin Associates with the Water-Soluble Porphyrins.	Water	58-63	ferritin heavy chain 1	Homo sapiens	26-37
22373544-4	2012	We establish the membrane ions" contributions (sodium, potassium, calcium and iron) mediated by water to the antagonism of these drugs at the 5-HT1A receptor.	Water	96-101	5-hydroxytryptamine receptor 1A	Homo sapiens	142-157
34161607-1	2021	The association behavior of apoferritin species with the anionic porphyrins, 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin (H2 TPPS4- ) and its zinc(II) complex (ZnTPPS4- ), which are water-soluble even in acidic solutions, was investigated for the first time through UV-vis absorption and fluorescence spectroscopy in order to evaluate a potential ability of apoferritin as a stimuli-responsive molecular capsule.	Water	186-191	ferritin heavy chain 1	Homo sapiens	28-39
22299724-3	2012	AEAs and VDEs obtained by MP2 and DFT/B3LYP methods copy trends of benchmark CCSD(T) results for the free uracil and uracil-water complexes in the gas phase being by 0.20 - 0.28 eV higher than CCSD(T) values depending on the particular structure of the complex.	Water	124-129	tryptase pseudogene 1	Homo sapiens	26-29
34501048-7	2021	The new Eco-concretes deliver the desired performance in terms of processability, strength and durability (water penetration, frost, carbonation and chloride resistance) while lowering the environmental impact in comparison to standard concrete.	Water	107-112	ciliogenesis associated kinase 1	Homo sapiens	8-11
21830934-8	2012	CONCLUSION: Owing to its hydrophilic nature, the bond strength produced by Adper PLP (a HEMA-containing self-etching primer) decreased significantly after T/12 weeks in water.	Water	169-174	proteolipid protein 1	Bos taurus	81-84
34448973-12	2021	Water deprivation increased plasma levels of beta-hydroxybutyrate, acetoacetate, corticosterone, and epinephrine and reduced the levels of adiponectin in T1DM mice.	Water	0-5	adiponectin, C1Q and collagen domain containing	Mus musculus	139-150
34448973-13	2021	Interleukin (IL) 1beta, IL-6, IL-8, and TNFalpha were also increased in the T1DM mice with water deprivation.	Water	91-96	interleukin 1 alpha	Mus musculus	0-22
34231284-3	2021	The chirality was originated from the point chirality of amino acid derivatives L-/D-PyLys hydrochlorides, and transferred to the planar conformational chirality of water-soluble pillar(5)arene pR-/pS-WP5.	Water	165-170	transmembrane protein 37	Homo sapiens	194-196
34432828-10	2021	Water kiosk use showed a protective association against T cell activation (p = 0.007), as well as endothelial damage (MIP1beta, sICAM1 and sVCAM1 p = 0.047, 0.026 and 0.031 respectively).	Water	0-5	C-C motif chemokine ligand 3	Homo sapiens	118-126
34405223-4	2021	The water balance mainly depends on the regulation of aquaporin-2 (AQP2) by arginine vasopressin (AVP) in renal collecting duct principal cells.	Water	4-9	aquaporin 2	Homo sapiens	54-65
34405223-4	2021	The water balance mainly depends on the regulation of aquaporin-2 (AQP2) by arginine vasopressin (AVP) in renal collecting duct principal cells.	Water	4-9	aquaporin 2	Homo sapiens	67-71
34505056-2	2021	The newly open water resulted from sea ice decline in turn exerts large influence on the atmosphere.	Water	15-20	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	35-38
34259277-2	2021	CP is used in many important applications, including the enrichment of trace analytes in microfluidic systems and water purification by electrodialysis.	Water	114-119	ceruloplasmin	Homo sapiens	0-2
34440877-1	2021	Saliva secretion requires effective translocation of aquaporin 5 (AQP5) water channel to the salivary glands (SGs) acinar apical membrane.	Water	72-77	aquaporin 5	Homo sapiens	53-64
34440877-1	2021	Saliva secretion requires effective translocation of aquaporin 5 (AQP5) water channel to the salivary glands (SGs) acinar apical membrane.	Water	72-77	aquaporin 5	Homo sapiens	66-70
34288691-8	2021	Even though the aggregation is driven by the hydrophobic interactions, ELP coacervate has no hydrophobic core and contains many water molecules.	Water	128-133	nuclear receptor subfamily 5 group A member 1	Homo sapiens	71-74
34319101-1	2021	We compute individual ion activity coefficients (IIACs) in aqueous NaCl, KCl, NaF, and KF solutions from explicit-water molecular dynamics simulations.	Water	114-119	arylformamidase	Homo sapiens	87-89
34351947-3	2021	The aim of this study is to assess the water quality parameters of basic water services in Amhara and Afar regions of Ethiopia as well as the role and importance of local managerial committees in ensuring basic water functionality.	Water	73-78	aldo-keto reductase family 7 member A2	Homo sapiens	102-106
34286770-1	2021	Recently prepared as a new H2O phase, ice XVI was obtained by degassing a Ne-sII clathrate hydrate under vacuum, however very little is known of that crystalline solid under temperatures (T <= 220 K) and pressures (p <= 5000 bar) relevant for the Earth"s environment and geochemistry.	Water	27-30	transcription elongation factor A1	Homo sapiens	77-80
33032209-3	2021	Although thermal treatment at <= 600  C did not lead to the collapse of zeolite framework, it removed H2O molecules from the coordination shell of extraframework Co2+, which in turn changed its coordination structure in a way to strengthen the interaction between Co2+ and the lattice oxygens.	Water	102-105	complement C2	Homo sapiens	162-165
33032209-3	2021	Although thermal treatment at <= 600  C did not lead to the collapse of zeolite framework, it removed H2O molecules from the coordination shell of extraframework Co2+, which in turn changed its coordination structure in a way to strengthen the interaction between Co2+ and the lattice oxygens.	Water	102-105	complement C2	Homo sapiens	264-267
33034701-3	2020	On the other hand, just like the esterification processes catalyzed by lipases, GH synthetic effectiveness is strongly obstructed by water both thermodynamically and kinetically.	Water	133-138	gamma-glutamyl hydrolase	Homo sapiens	80-82
25686794-5	2015	Differences observed between enzymatic cross-linking of beta-casein and k-casein at the air/water interface verified the importance of molecular structure and close packing for formation of an elastic protein network.	Water	92-97	casein beta	Homo sapiens	56-67
25698576-1	2015	The active cholera toxin responsible for the massive loss of water and ions in cholera patients via its ADP ribosylation activity is a heterodimer of the A1 subunit of the bacterial holotoxin and the human cytosolic ARF6 (ADP Ribosylation Factor 6).	Water	61-66	ADP ribosylation factor 6	Homo sapiens	216-220
24520713-0	2013	Removal of Cd2+ from water by Friedel"s salt (FS: 3CaO x A12O3 x CaCI2 x 10H2O): sorption characteristics and mechanisms.	Water	21-26	CD2 molecule	Homo sapiens	11-14
19409501-2	2009	Aquaporin 4 (AQP4), a water channel protein located at the blood-brain barrier, might facilitate the removal of this excess of water from the parenchyma into the blood.	Water	22-27	aquaporin 4	Rattus norvegicus	0-11
19409501-2	2009	Aquaporin 4 (AQP4), a water channel protein located at the blood-brain barrier, might facilitate the removal of this excess of water from the parenchyma into the blood.	Water	22-27	aquaporin 4	Rattus norvegicus	13-17
19409501-4	2009	We further hypothesized that movements of water through AQP4 could affect apparent diffusion coefficient (ADC) measurements.	Water	42-47	aquaporin 4	Rattus norvegicus	56-60
20107112-1	2010	Transient receptor potential channels TRPC3 and TRPC6 are expressed in principal cells of the collecting duct (CD) along with the water channel aquaporin-2 (AQP2) both in vivo and in the cultured mouse CD cell line IMCD-3.	Water	130-135	aquaporin 2	Mus musculus	157-161
14993810-0	2004	Potentiation of cytotoxic activity in naive and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies.	Water	97-102	alcohol dehydrogenase, iron containing, 1	Mus musculus	93-96
14993810-1	2004	When hot-water extracts of mushroom Agaricus brazei MURRILL fruiting bodies (Agaricus extracts) were administered orally into Meth A-bearing mice, tumor growth was significantly inhibited compared with controls given water orally.	Water	9-14	alcohol dehydrogenase, iron containing, 1	Mus musculus	5-8
14993810-1	2004	When hot-water extracts of mushroom Agaricus brazei MURRILL fruiting bodies (Agaricus extracts) were administered orally into Meth A-bearing mice, tumor growth was significantly inhibited compared with controls given water orally.	Water	217-222	alcohol dehydrogenase, iron containing, 1	Mus musculus	5-8
11710174-2	2000	The enzymatic transformation of PCL having an Mn of 110,000 using Candida antarctica lipase (lipase CA) in water-containing toluene at 40 degrees C afforded the corresponding cyclic dicaprolactone (DCL, 1,8-dioxacyclotetradecane-2,9-dione) in a yield of up to 97%.	Water	107-112	PAN0_003d1715	Moesziomyces antarcticus	85-91
11710174-2	2000	The enzymatic transformation of PCL having an Mn of 110,000 using Candida antarctica lipase (lipase CA) in water-containing toluene at 40 degrees C afforded the corresponding cyclic dicaprolactone (DCL, 1,8-dioxacyclotetradecane-2,9-dione) in a yield of up to 97%.	Water	107-112	PAN0_003d1715	Moesziomyces antarcticus	93-99
7512015-9	1994	Water-immersion stress significantly increased myeloperoxidase activity in gastric mucosa, and FK506 reduced the increase in myeloperoxidase activity induced by stress.	Water	0-5	myeloperoxidase	Rattus norvegicus	47-62
34608726-2	2022	Due to the slow proton-feeding rates from sluggish water dissociation kinetics, however, the CO2RR process involving multi-electron and proton transfer is greatly limited by poor selectivity and low yield.	Water	51-56	complement C2	Homo sapiens	93-98
34962791-10	2022	Water dissociation kinetics is increasingly promoted by strongly acidic cations (Nd3+, Al3+), in agreement with experimental evidence.	Water	0-5	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	81-84
22210205-4	2012	The VLP abundance and VLP-to-prokaryote ratio (VPR) in the planktonic habitats increased as the ratio of hydrothermal fluid to mixing water increased.	Water	134-139	VHL like	Homo sapiens	4-7
34661921-7	2022	When 5 min SB-ITME at room temperature was applied to a tap water sample, the EFs of 2,4,6-trichlorophenol (TCP), 2,3,6-TCP and 2,6-dichlorophenol were 53, 41 and 60, respectively, and the LOQs obtained by monitoring the absorbance at 214 nm were about 7.8 ppb, much lower than 200 ppb, the World Health Organization guideline for the maximum permissible concentration of 2,4,6-TCP in drinking water.	Water	60-65	TARBP2 subunit of RISC loading complex	Homo sapiens	189-193
22245855-2	2012	Establishing diverse native plant communities on ski runs should enhance sediment and water retention, wildlife habitat, biodiversity and aesthetics.	Water	86-91	SKI proto-oncogene	Homo sapiens	49-52
20822887-7	2012	Pretreatment with quercitrin also reduced the increase in bone-resorbing factor, receptor activator of nuclear factor-kB ligand (RANKL) and oxidative damage markers (malondialdehyde, protein carbonyl, and nitrotyrosine) induced by H(2)O(2).	Water	231-236	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	81-127
34953448-7	2022	We then found that promoting USP20 expression remarkably ameliorated MCAO-induced ischemic brain injury, along with significantly reduced infarct volume, neurological scores and brain water contents.	Water	184-189	ubiquitin specific peptidase 20	Mus musculus	29-34
22024150-1	2012	BACKGROUND: KCNQ1 (Kv7.1), together with its KCNE beta subunits, plays a pivotal role both in the repolarization of cardiac tissue and in water and salt transport across epithelial membranes.	Water	138-143	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	12-17
34798586-0	2022	Mercapto-functionalized ordered mesoporous silica-modified PVDF membrane for efficiently scavenging Cd2+ from water.	Water	110-115	CD2 molecule	Homo sapiens	100-103
34798586-2	2022	The OMS materials were analyzed by FT-IR spectra, N2 sorption, and small angle X-ray scattering to evaluate their potential for scavenging Cd2+ from water.	Water	149-154	CD2 molecule	Homo sapiens	139-142
34798586-5	2022	The MPTMS-OMS/PVDF exhibited a dynamic adsorption capacity for Cd2+ in water.	Water	71-76	CD2 molecule	Homo sapiens	63-66
22024150-1	2012	BACKGROUND: KCNQ1 (Kv7.1), together with its KCNE beta subunits, plays a pivotal role both in the repolarization of cardiac tissue and in water and salt transport across epithelial membranes.	Water	138-143	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	19-24
34890772-9	2022	BaP-treated high-affinity AhrbCyp1a2(-/-) mice had greater impairments in Morris water maze.	Water	81-86	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	26-36
21625899-5	2012	Then, based on the optimized geometric structure of the Arg(+)+9H(2)O system, the electronic structure of Arg(+) in the potential of water was calculated using the SCCE method.	Water	133-138	kallikrein related peptidase 7	Homo sapiens	164-168
21625899-6	2012	Finally, by performing SCCE calculations, the effect of water on the electronic structure of Arg(+) was simulated with dipoles.	Water	56-61	kallikrein related peptidase 7	Homo sapiens	23-27
34920350-3	2022	The probe compound is CCl4, where its eliminated amount within a single bubble (though pyrolysis) is determined via a cavitation model which takes into account the non-equilibrium condensation/evaporation of water vapor and heat exchange across the bubble wall, reactions heats and liquid compressibility and viscosity, all along the bubble oscillation under the temporal perturbation of the ultrasonic wave.	Water	208-213	C-C motif chemokine ligand 4	Homo sapiens	22-26
22250214-1	2012	The NKCC1 and NKCC2 isoforms of the mammalian Na+-K+-2Cl- cotransporter were expressed in Xenopus oocytes and the relation between external ion concentration and water fluxes determined.Water fluxes were determined from changes in the oocytes volume and ion fluxes from 86Rb+ uptake.	Water	186-191	solute carrier family 12 member 2	Homo sapiens	4-9
34984311-0	2021	Mechanism of the Production Impact in Shale Gas Wells Caused by Water Invasion during Interwell Interference.	Water	64-69	gastrin	Homo sapiens	44-47
22545405-5	2012	The structure of dimerized griseofulvin, C34H32C12O12 x C2H6O x H2O, at 100 K has monoclinic (P2(1)) symmetry.	Water	64-67	H3 histone pseudogene 16	Homo sapiens	94-99
34984311-4	2021	According to the mechanism of spontaneous imbibition and water drainage in shale mico- and nanoscale pores, this paper introduces the water-gas distribution during fracturing and production and reveals that water drainage in micro- and nanoscale pores is mainly controlled by the amount of stored gas and follows the order of pore size.	Water	57-62	gastrin	Homo sapiens	140-143
34984311-4	2021	According to the mechanism of spontaneous imbibition and water drainage in shale mico- and nanoscale pores, this paper introduces the water-gas distribution during fracturing and production and reveals that water drainage in micro- and nanoscale pores is mainly controlled by the amount of stored gas and follows the order of pore size.	Water	57-62	gastrin	Homo sapiens	297-300
34984311-4	2021	According to the mechanism of spontaneous imbibition and water drainage in shale mico- and nanoscale pores, this paper introduces the water-gas distribution during fracturing and production and reveals that water drainage in micro- and nanoscale pores is mainly controlled by the amount of stored gas and follows the order of pore size.	Water	134-139	gastrin	Homo sapiens	140-143
34984311-4	2021	According to the mechanism of spontaneous imbibition and water drainage in shale mico- and nanoscale pores, this paper introduces the water-gas distribution during fracturing and production and reveals that water drainage in micro- and nanoscale pores is mainly controlled by the amount of stored gas and follows the order of pore size.	Water	134-139	gastrin	Homo sapiens	297-300
34984311-4	2021	According to the mechanism of spontaneous imbibition and water drainage in shale mico- and nanoscale pores, this paper introduces the water-gas distribution during fracturing and production and reveals that water drainage in micro- and nanoscale pores is mainly controlled by the amount of stored gas and follows the order of pore size.	Water	207-212	gastrin	Homo sapiens	140-143
34984311-4	2021	According to the mechanism of spontaneous imbibition and water drainage in shale mico- and nanoscale pores, this paper introduces the water-gas distribution during fracturing and production and reveals that water drainage in micro- and nanoscale pores is mainly controlled by the amount of stored gas and follows the order of pore size.	Water	207-212	gastrin	Homo sapiens	297-300
34984311-6	2021	It is concluded that the secondary water invasion caused by interwell interference completely blocks the pores associated with long-term gas production but has little influence on the pores that have not yet drained or have produced only a small amount of gas, and smaller pores face a greater risk of water blockage.	Water	35-40	gastrin	Homo sapiens	137-140
21841825-3	2012	Here we report that H-RasV12 positively regulates the NADPH oxidase system NOX4-p22(phox) that produces H(2)O(2).	Water	104-109	prohibitin 2	Homo sapiens	80-83
22202168-0	2012	Changes in serum thioredoxin among individuals chronically exposed to arsenic in drinking water.	Water	90-95	thioredoxin	Homo sapiens	17-28
34563852-4	2021	However, in the irrigated areas along the middle and lower reaches of inland rivers (e.g., the Amu Darya and Syr Darya), water pollution is strongly associated with agriculture.	Water	121-126	YES1 pseudogene 1	Homo sapiens	109-112
22202168-3	2012	In this study, we examined the differences in the levels of serum thioredoxin1 (TRX1) among individuals exposed to different levels of arsenic in drinking water and detected early biomarkers of arsenic poisoning before the appearance of skin lesions.	Water	155-160	thioredoxin	Homo sapiens	66-78
22202168-3	2012	In this study, we examined the differences in the levels of serum thioredoxin1 (TRX1) among individuals exposed to different levels of arsenic in drinking water and detected early biomarkers of arsenic poisoning before the appearance of skin lesions.	Water	155-160	thioredoxin	Homo sapiens	80-84
34851644-0	2021	Influence of Water and Enzyme on the Post-Transition State Bifurcation of NgnD-Catalyzed Ambimodal (6+4)/(4+2) Cycloaddition.	Water	13-18	solute carrier family 35 member G1	Homo sapiens	37-41
22202168-8	2012	A positive correlation was seen between the levels of serum TRX1 and the total water arsenic intake or the levels of urinary arsenic species.	Water	79-84	thioredoxin	Homo sapiens	60-64
34851644-3	2021	Here, we study the impact of water and enzyme on the post-transition state bifurcation of NgnD-catalyzed (6+4)/(4+2) cycloaddition by integrating quantum mechanics/molecular mechanics quasiclassical dynamics simulations and biochemical assays.	Water	29-34	solute carrier family 35 member G1	Homo sapiens	53-57
34394397-2	2021	PG2 or PA applied to skin of hairless mice after UVB-irradiation alleviated UVB-induced effects observed in untreated skin, such as increased transepidermal water loss (TEWL), increased epidermal thickness, and decreased stratum corneum water content without affecting body weight.	Water	157-162	lysine demethylase and nuclear receptor corepressor	Mus musculus	29-37
22325688-0	2012	Persistent elevation of urine aquaporin-2 during water loading in a child with nephrogenic syndrome of inappropriate antidiuresis (NSIAD) caused by a R137L mutation in the V2 vasopressin receptor.	Water	49-54	aquaporin 2	Homo sapiens	30-41
34394397-2	2021	PG2 or PA applied to skin of hairless mice after UVB-irradiation alleviated UVB-induced effects observed in untreated skin, such as increased transepidermal water loss (TEWL), increased epidermal thickness, and decreased stratum corneum water content without affecting body weight.	Water	237-242	lysine demethylase and nuclear receptor corepressor	Mus musculus	29-37
34898192-4	2022	Here, computational and experimental findings reveal that residue 99 is a key contributor to the observed species selectivity, whereby enthalpically unfavorable expulsion of a water molecule by the 5-N,N-hexamethylene ring occurs when residue 99 is Tyr (as in mouse uPA).	Water	176-181	plasminogen activator, urokinase	Mus musculus	266-269
22325688-2	2012	We report the effect of water loading in a 3-year old boy with NSIAD, diagnosed in infancy, to assess urine aquaporin-2 (AQP2) excretion as a marker for V2R activation, and to evaluate the progression of the disease since diagnosis.	Water	24-29	aquaporin 2	Homo sapiens	108-119
34961219-5	2021	Compared with the water control treatment, the combined ABA + CaCl2 treatment significantly improved the superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) of the seedlings by 34.47%, 59.66%, and 118.80%, respectively (p < 0.05), and significantly reduced the chilling injury index, relative electrical conductivity, and MDA content, by 89.47%, 62.17%, and 44.55%, respectively (p < 0.05).	Water	18-23	superoxide dismutase [Mn], mitochondrial	Cucumis sativus	105-125
34961219-5	2021	Compared with the water control treatment, the combined ABA + CaCl2 treatment significantly improved the superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) of the seedlings by 34.47%, 59.66%, and 118.80%, respectively (p < 0.05), and significantly reduced the chilling injury index, relative electrical conductivity, and MDA content, by 89.47%, 62.17%, and 44.55%, respectively (p < 0.05).	Water	18-23	superoxide dismutase [Mn], mitochondrial	Cucumis sativus	127-130
22325688-11	2012	In conclusion, this is the first demonstration in a patient with NSIAD caused by a R137L mutation in the V2R that urine AQP2 excretion is inappropriately elevated and does not suppress normally with water loading.	Water	199-204	aquaporin 2	Homo sapiens	120-124
34614847-7	2021	When the intervening gas is isothermal and the optical distance from surface to detector is considered optically thin, the temperature error has linear growth with both the H2O-CO2-CO-N2 mixture concentration and viewing path length increasing.	Water	173-176	gastrin	Homo sapiens	21-24
22194034-1	2012	We perform a comparative theoretical analysis of adsorption of dyes NK1 (2E,4E-2-cyano-5-(4-dimethylaminophenyl)penta-2,4-dienoic acid) and NK7 (2E,4E-2-cyano-5-(4-diphenylaminophenyl)penta-2,4-dienoic acid) on clean and water-covered anatase (101) surfaces of TiO(2).	Water	221-226	tachykinin receptor 1	Homo sapiens	68-71
34812811-0	2021	Self-supporting CoP-C nanosheet arrays derived from a metal-organic framework as synergistic catalysts for efficient water splitting.	Water	117-122	caspase recruitment domain family member 16	Homo sapiens	16-19
22212389-1	2012	AIM: Aquaporin-2 (AQP2) is a vasopressin-regulated water channel located in the collecting tubule and collecting duct cells of mammalian kidney.	Water	51-56	aquaporin 2	Homo sapiens	5-16
34961160-10	2021	Similarly, the water extract exhibited AGI activity (IC50 = 6.75 mug/mL), insulin-sensitizing activity at the concentration of 10 mug/mL, and antioxidant activities (IC50 = 27.12 and 33.71 mug/mL for DPPH and FRAP activity, respectively).	Water	15-20	preproinsulin	Danio rerio	74-81
34961160-10	2021	Similarly, the water extract exhibited AGI activity (IC50 = 6.75 mug/mL), insulin-sensitizing activity at the concentration of 10 mug/mL, and antioxidant activities (IC50 = 27.12 and 33.71 mug/mL for DPPH and FRAP activity, respectively).	Water	15-20	mechanistic target of rapamycin kinase	Mus musculus	209-213
34925053-2	2021	Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the collecting duct principal cells to increase water permeability.	Water	79-84	aquaporin 2	Mus musculus	101-112
34120034-4	2021	The main objective of our study was to evaluate the expression of cyp19a aromatase as a toxicological endpoint after BPA exposure through the identification and assessment of alterations of the main cells responsible for cyp19a1a and cyp19a1b expression in the zebrafish ovary and brain using different concentrations of BPA in water.	Water	328-333	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	66-72
34120034-4	2021	The main objective of our study was to evaluate the expression of cyp19a aromatase as a toxicological endpoint after BPA exposure through the identification and assessment of alterations of the main cells responsible for cyp19a1a and cyp19a1b expression in the zebrafish ovary and brain using different concentrations of BPA in water.	Water	328-333	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	221-229
34120034-8	2021	To our knowledge, this study is the first to localize and quantify the expression of cyp19a1a and cyp19a1b in the cells of brain and ovary after fish exposure to different BPA concentrations in water.	Water	194-199	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	85-93
22212389-1	2012	AIM: Aquaporin-2 (AQP2) is a vasopressin-regulated water channel located in the collecting tubule and collecting duct cells of mammalian kidney.	Water	51-56	aquaporin 2	Homo sapiens	18-22
22314846-5	2012	ANO 1 is present in the apical membranes of various secretory epithelia in which it is co-localized with the water channel aquaporin 5.	Water	109-114	anoctamin 1	Homo sapiens	0-5
34294987-5	2021	The initial relaxation time of T21 was decreased significantly (P < 0.05), and the peak ration of P21 was increased significantly (P < 0.05) when treated at 200 and 300 MPa, that indicated the water was bound tightly and the ratio of immobilized water was increased.	Water	193-198	H3 histone pseudogene 16	Homo sapiens	98-101
34294987-5	2021	The initial relaxation time of T21 was decreased significantly (P < 0.05), and the peak ration of P21 was increased significantly (P < 0.05) when treated at 200 and 300 MPa, that indicated the water was bound tightly and the ratio of immobilized water was increased.	Water	246-251	H3 histone pseudogene 16	Homo sapiens	98-101
34925053-2	2021	Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the collecting duct principal cells to increase water permeability.	Water	194-199	aquaporin 2	Mus musculus	101-112
34787391-0	2021	Structural and Componential Engineering of Co2P&CoP@N-C Nanoarrays for Energy-Efficient Hydrogen Production from Water Electrolysis.	Water	113-118	complement C2	Homo sapiens	43-46
22038261-4	2012	The availability of ROMK(-/-) mice has made it possible to study electrolyte transport along the nephron in order to understand the TAL function under physiological conditions and the compensatory mechanisms of salt and water transport under the conditions of TAL dysfunction.	Water	220-225	potassium inwardly-rectifying channel, subfamily J, member 1	Mus musculus	20-24
34432538-2	2021	In the renal collecting duct, the water channel aquaporin-2 localizes to the apical plasma membrane as well as small, sub-apical vesicles.	Water	34-39	aquaporin 2	Homo sapiens	48-59
34184080-12	2021	Consistent with the in vitro results, administration of MFR water extract to OVX rats reduced BMD loss, and reduced the expression levels of NFATc1 and cathepsin K in the femoral head.	Water	60-65	nuclear factor of activated T-cells 1	Rattus norvegicus	141-147
34184080-12	2021	Consistent with the in vitro results, administration of MFR water extract to OVX rats reduced BMD loss, and reduced the expression levels of NFATc1 and cathepsin K in the femoral head.	Water	60-65	cathepsin K	Rattus norvegicus	152-163
21955990-9	2012	A distinct shift of the picocyanobacterial community was observed from the Bering Sea to the Chukchi Sea, which reflected the change of water temperature.	Water	136-141	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	82-85
34753563-10	2021	The optimized method provided limits of quantitation (LOQs) ranged from 0.002 to 0.02 ng mL-1 in water and from 0.095 to 0.48 ng g-1 in apple juice.	Water	97-102	L1 cell adhesion molecule	Mus musculus	89-93
21955990-9	2012	A distinct shift of the picocyanobacterial community was observed from the Bering Sea to the Chukchi Sea, which reflected the change of water temperature.	Water	136-141	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	101-104
22047918-0	2012	Removal of Cd2+ from contaminated water by nano-sized aragonite mollusk shell and the competition of coexisting metal ions.	Water	34-39	CD2 molecule	Homo sapiens	11-14
34115555-5	2021	Upregulation of miR-126 in CLP rats could improve brain injury and BBB marker protein level, reduce brain water content, Evans blue extravasation, inflammation, and excessive oxidative stress.	Water	106-111	microRNA 126b	Rattus norvegicus	16-23
34198025-3	2021	METHODS: The Monte Carlo code MDM was extended to the case of swift ion impact on liquid water (MDM-Ion).	Water	89-94	secreted LY6/PLAUR domain containing 1	Homo sapiens	30-33
34198025-3	2021	METHODS: The Monte Carlo code MDM was extended to the case of swift ion impact on liquid water (MDM-Ion).	Water	89-94	secreted LY6/PLAUR domain containing 1	Homo sapiens	96-99
34560994-5	2021	The electrospun CP/PEO nanofiber mats exhibited good mechanical strength, thermal stability, and hydrophobicity with water contact angles up to 133 .	Water	117-122	ceruloplasmin	Homo sapiens	16-18
22320824-0	2012	Determination of absorbed dose to water around a clinical HDR (192)Ir source using LiF:Mg,Ti TLDs demonstrates an LET dependence of detector response.	Water	34-39	LIF interleukin 6 family cytokine	Homo sapiens	83-86
22320824-22	2012	CONCLUSIONS: When calibrated in (60)Co or MV photon beams, correction for the linear energy transfer (LET) dependence of LiF:Mg,Ti detector response will be needed as to measure absorbed doses to water in a (192)Ir beam with highest accuracy.	Water	196-201	LIF interleukin 6 family cytokine	Homo sapiens	121-124
34716532-14	2021	The relative expression of interleukin-1beta in 15 and 35% groups was higher than that in the other groups; however, the relative expression of lysozyme gene in the liver of fish reared at fresh water was pronouncedly lower than that in the other treatments.	Water	195-200	lysozyme C	Lates calcarifer	144-152
21993890-1	2012	The degree of water transport via aquaporin-2 (AQP2) water channels in renal collecting duct principal cells is reflected by the level of the urinary excretion of AQP2 (u-AQP2).	Water	14-19	aquaporin 2	Homo sapiens	34-45
34321467-7	2021	The Ru1/D-NiFe LDH as an ideal model reveals superior water splitting performance with potential for the development of promising water-alkali electrocatalysts.	Water	54-59	Scm like with four mbt domains 1	Homo sapiens	4-7
34321467-7	2021	The Ru1/D-NiFe LDH as an ideal model reveals superior water splitting performance with potential for the development of promising water-alkali electrocatalysts.	Water	130-135	Scm like with four mbt domains 1	Homo sapiens	4-7
34784711-2	2021	The amount of resistant starch (RS) was significantly lowered in the water-soluble polysaccharide (WSP), water-soluble polysaccharide-pectinase (WSP-P), and water-insoluble polysaccharide-alkali soluble (WISP-Alk-Soluble; p < 0.05).	Water	157-162	sorting nexin 9	Homo sapiens	204-208
34510301-0	2021	Deuterium-depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration.	Water	19-24	solute carrier family 2 member 4	Rattus norvegicus	36-41
34152558-0	2021	Single boll weight depends on photosynthetic function of boll-leaf system in field-grown cotton plants under water stress.	Water	109-114	boule homolog, RNA binding protein	Homo sapiens	7-11
34152558-0	2021	Single boll weight depends on photosynthetic function of boll-leaf system in field-grown cotton plants under water stress.	Water	109-114	boule homolog, RNA binding protein	Homo sapiens	57-61
34152558-2	2021	Under water stress, the single boll weight (SBW) of cotton remains relatively stable, while both the leaf area and leaf photosynthetic rate decrease greatly.	Water	6-11	boule homolog, RNA binding protein	Homo sapiens	31-35
34152558-4	2021	Considering the cotton boll-leaf system (BLS: including the main-stem leaf, sympodial leaves, and non-leaf organs) as the basic unit of the cotton canopy, we speculated that the formation of SBW may depend on photosynthesis in the corresponding BLS under water stress.	Water	255-260	boule homolog, RNA binding protein	Homo sapiens	23-27
34884753-2	2021	One of the key factors in the maintenance of body water balance is water reabsorption in the collecting ducts of the kidney, a process that is regulated by aquaporin-2 (AQP2).	Water	50-55	aquaporin 2	Homo sapiens	156-167
34884753-2	2021	One of the key factors in the maintenance of body water balance is water reabsorption in the collecting ducts of the kidney, a process that is regulated by aquaporin-2 (AQP2).	Water	50-55	aquaporin 2	Homo sapiens	169-173
34884753-2	2021	One of the key factors in the maintenance of body water balance is water reabsorption in the collecting ducts of the kidney, a process that is regulated by aquaporin-2 (AQP2).	Water	67-72	aquaporin 2	Homo sapiens	156-167
34884753-2	2021	One of the key factors in the maintenance of body water balance is water reabsorption in the collecting ducts of the kidney, a process that is regulated by aquaporin-2 (AQP2).	Water	67-72	aquaporin 2	Homo sapiens	169-173
34884753-3	2021	AQP2 is a channel that is exclusively selective for water molecules and impermeable to ions or other small molecules.	Water	52-57	aquaporin 2	Homo sapiens	0-4
34884753-4	2021	Impairments of AQP2 result in various water balance disorders, including nephrogenic diabetes insipidus (NDI), which is a disease characterized by a massive loss of water through the kidney and consequent severe dehydration.	Water	165-170	aquaporin 2	Homo sapiens	15-19
34884753-5	2021	Dysregulation of AQP2 is also a cause of water retention with hyponatremia in heart failure, hepatic cirrhosis, and syndrome of inappropriate antidiuretic hormone secretion (SIADH).	Water	41-46	aquaporin 2	Homo sapiens	17-21
34884753-7	2021	Its binding to the vasopressin V2 receptor promotes AQP2 targeting to the apical membrane and thus enables water reabsorption.	Water	107-112	aquaporin 2	Homo sapiens	52-56
34883918-4	2021	It belongs to the general class of volatile organic compounds and can be found in water or in the atmosphere as pollutants released from a variety of processes; its detection with SERS is typically challenging, due to its low affinity toward metallic surfaces.	Water	82-87	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	180-184
34887234-5	2021	The prediction was that treated water would result in increased cell proliferation, that more cells would enter the cell cycle growth phase, and that there would be increased expression of genes (NANOG, OCT4 and SOX2) associated with improved cell growth and decreased expression of genes (p16, p21, and p53) associated with a decline in cell growth.	Water	32-37	POU class 5 homeobox 1	Homo sapiens	203-207
34887234-5	2021	The prediction was that treated water would result in increased cell proliferation, that more cells would enter the cell cycle growth phase, and that there would be increased expression of genes (NANOG, OCT4 and SOX2) associated with improved cell growth and decreased expression of genes (p16, p21, and p53) associated with a decline in cell growth.	Water	32-37	H3 histone pseudogene 16	Homo sapiens	295-298
34225150-10	2021	The micronucleus assay indicated significant increase of micronucleus frequencies (41.25%, 35.48%, 21.66%, 16.23% and 13.62% respectively for P1, P2, P3, P4 and P7) which were higher than the negative control (0%) and the irrigated soil by fresh water (3.29%).	Water	246-251	solute carrier family 10 member 4	Homo sapiens	154-163
34473153-6	2021	Herein we demonstrate Ru1-catalyzed H2O2 disproportionation into O2 and H2O, exhibiting an 8,580-fold faster catalase TOF vs. peroxidase TOF, which is 89.2-fold greater than the highest value reported for a Mn-porphyin or -salen complex.	Water	72-75	Scm like with four mbt domains 1	Homo sapiens	22-25
34748071-2	2021	Sea ice is a marine habitat, which is composed of a matrix of solid ice and pockets of saline water in which Ciliophora thrive.	Water	94-99	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
34748071-6	2021	Under-ice water and the water column were distinctly predominated by planktonic orders Choreotrichida and Oligotrichida, which led to significantly lower taxonomic and functional evenness in water than in sea ice.	Water	10-15	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	205-208
34738214-1	2022	This study aimed to investigate the degradability, mineralization, proposed decomposition pathway, intermediate products, and toxicity of effluent from trichlorfon (TCF) degradation in water by UV/sulfite-advanced reduction process (UV/S-ARP).	Water	185-190	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	238-241
34644688-3	2021	In this work, we develop a new coating material, LiH2PO4, which can effectively optimize the residual alkali on the surface of NCA to remove H2O and CO2 and form a coating layer with excellent ion conductivity.	Water	141-144	CEA cell adhesion molecule 6	Homo sapiens	127-130
34155585-8	2021	Principal component analysis (PCA) combined with absolute principal component score-multiple linear regression model (APCS-MLR) further appointed the source contribution of each pollution source to water quality indicators.	Water	198-203	amyloid P component, serum	Homo sapiens	118-122
34155585-12	2021	Based on the results of APCS-MLR, it was predicted that the concentrations of COD and TP in Honghu Lake would meet the water quality requirements after 2017.	Water	119-124	amyloid P component, serum	Homo sapiens	24-28
34164790-1	2021	The cardiovascular drugs (CDDs), such as metoprolol (MET), atenolol (ATE), bezafibrate (BZB), and atorvastatin (ATO), have been frequently detected in the water environment.	Water	155-160	SAFB like transcription modulator	Homo sapiens	53-56
34641673-1	2021	Solvothermal reactions between hexanuclear complexes with the general chemical formula (Ln6(mu6-O)(mu3-OH)8(NO3)6(H2O)12) 2NO3 2H2O and 2-bromobenzoic acid (2-bbH) lead to a series of isostructural one-dimensional coordination polymers with the general chemical formula (Ln2(2-bb)6)  with Ln = Sm, Eu, Tb, Dy, and Y.	Water	114-117	gamma-butyrobetaine hydroxylase 1	Homo sapiens	159-162
34644054-1	2021	A new type of metal-organic framework, (Cd2(pdc)(H2O)(DMA)2)n (pdc = 3,5-pyrazoledicarboxylic acid; DMA = dimethylamine), named Cd-MOF, was synthesized and characterized.	Water	49-52	CD2 molecule	Homo sapiens	40-43
34688659-7	2021	On the other hand, the conditional deletion of Dhps or Eif5a by Camk2a promoter-driven Cre expression (postnatal, mainly in the CA1 region of the hippocampus) did not lead to global developmental defects; rather, these knockout animals exhibited severe impairment in spatial learning, contextual learning, and memory when subjected to the Morris Water Maze and a contextual learning test.	Water	346-351	deoxyhypusine synthase	Mus musculus	47-51
34507633-7	2021	In this review article, we discuss the beneficial effects of SGLT2 inhibition from the perspective of energy metabolism and water conservation.	Water	124-129	solute carrier family 5 member 2	Homo sapiens	61-66
34173312-0	2021	A ready-to-use fluorescence probe of Pd2+ in water: novel tricyclic heterocyclic base on 1,3,4- Oxadiazole.	Water	45-50	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	37-40
34173312-1	2021	This paper, a ready-to-use hetero-tricyclic compound, 5,5"-(furan-2,5-diyl) bis (1,3,4- oxadiazol-2-amine) (5), was synthesized with a good yield, which has an nice fluorescence character and research founded that it can respond to a trace Pd2+ in the water at proper pH range.	Water	252-257	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	240-243
34745849-1	2021	Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis.	Water	46-51	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
34745849-1	2021	Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis.	Water	46-51	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
34606272-3	2021	The purpose of this work is to explore new chemical modification strategies of two-photon excitation fluorescence (TPEF) probes to improve the poor water solubility and low efficiency in imaging applications.	Water	148-153	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	115-119
34672539-2	2021	Here, in the absence of cocatalysts, H2O overall splitting has been achieved by single-atomic S vacancy hexagonal CdS with a spin polarization electric field (PEF).	Water	37-40	CDP-diacylglycerol synthase 1	Homo sapiens	114-117
34672539-4	2021	By systematically tuning the spin PEF intensity with single-atomic S vacancy content, common pristine CdS is converted to a photocatalyst that can efficiently complete H2O overall splitting by releasing a great number of H2 bubbles under natural solar light.	Water	168-171	CDP-diacylglycerol synthase 1	Homo sapiens	102-105
34605842-8	2021	Cytotoxicity evaluation of these water-soluble nanoclusters gave CC50 values of 36 mug mL-1 and 70 mug mL-1 against A549 human alveolar epithelial cells, and 30 mug mL-1 and 40 mug mL-1 against NIH/3T3 mouse fibroblast cells for (Au9(TPPMS)8)Cl3 and (Au9(DPPBA)8)Cl3, respectively.	Water	33-38	L1 cell adhesion molecule	Mus musculus	87-98
34605842-8	2021	Cytotoxicity evaluation of these water-soluble nanoclusters gave CC50 values of 36 mug mL-1 and 70 mug mL-1 against A549 human alveolar epithelial cells, and 30 mug mL-1 and 40 mug mL-1 against NIH/3T3 mouse fibroblast cells for (Au9(TPPMS)8)Cl3 and (Au9(DPPBA)8)Cl3, respectively.	Water	33-38	L1 cell adhesion molecule	Mus musculus	165-176
34721438-4	2021	TREM1 inhibitory peptide LP17 alleviated the neurological deficits, attenuated brain water content, and reduced neuronal damage after SAH.	Water	85-90	triggering receptor expressed on myeloid cells 1	Homo sapiens	0-5
34642412-1	2021	The effects of (Co2 (SCN) 4(hmt)2(H2O)6.	Water	34-37	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	16-33
34569579-3	2021	Here we combined quantitative NMR with NMR titration experiments to rigorously quantify the interaction of the low water-solubility drug pimecrolimus with its target protein FKBP12.	Water	115-120	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	174-180
34242632-9	2021	AQP2, an arginine vasotocin (AVT)-sensitive water channel, is exclusively expressed in the principal cells of the collecting duct (CD).	Water	44-49	aquaporin 2	Homo sapiens	0-4
34242632-10	2021	AQP4 is unlikely to participate in free water resorption from the collecting duct (CD), and only AQP3 may represent an exit pathway for water reabsorbed apically via AQP2.	Water	136-141	aquaporin 3 (Gill blood group)	Homo sapiens	97-101
34242632-10	2021	AQP4 is unlikely to participate in free water resorption from the collecting duct (CD), and only AQP3 may represent an exit pathway for water reabsorbed apically via AQP2.	Water	136-141	aquaporin 2	Homo sapiens	166-170
34225022-5	2021	This observation is supported by plotting the free energy profiles of water molecules transport and calculating permeability values through AQP5-R188C, such that the energy barrier in the SF region of the pores was substantially reduced by this mutation, and therefore, the translocation of water molecules was improved.	Water	70-75	aquaporin 5	Homo sapiens	140-144
34225022-5	2021	This observation is supported by plotting the free energy profiles of water molecules transport and calculating permeability values through AQP5-R188C, such that the energy barrier in the SF region of the pores was substantially reduced by this mutation, and therefore, the translocation of water molecules was improved.	Water	291-296	aquaporin 5	Homo sapiens	140-144
34224008-0	2021	Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus.	Water	19-24	aquaporin 2	Homo sapiens	14-18
34224008-2	2021	Renal unresponsiveness to the antidiuretic hormone vasopressin impairs aquaporin-2 (AQP2) water channel activity and water reabsorption from urine, resulting in polyuria.	Water	90-95	aquaporin 2	Homo sapiens	71-82
34224008-2	2021	Renal unresponsiveness to the antidiuretic hormone vasopressin impairs aquaporin-2 (AQP2) water channel activity and water reabsorption from urine, resulting in polyuria.	Water	90-95	aquaporin 2	Homo sapiens	84-88
34585475-11	2022	Remarkably, chronic administration in the drinking water of the orally bioavailable ATX inhibitor PF-8380 delayed MN loss, motor deterioration and prolonged life span in ALS mice.	Water	51-56	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	84-87
34584160-6	2021	Finally, an enhancement of 21.6% in COP was recorded for Al2O3-TiO2/EG-water nanofluids at a 5% nanoparticle volume concentration.	Water	71-76	caspase recruitment domain family member 16	Homo sapiens	36-39
34231595-0	2021	Co(OH)2 water oxidation cocatalyst-decorated CdS nanowires for enhanced photocatalytic CO2 reduction performance.	Water	8-13	CDP-diacylglycerol synthase 1	Homo sapiens	45-48
34369673-10	2021	The fecal water content, stool form score and SIPR, and expression level of 5-HT7R protein and mRNA in the gastric antrum and colon were significantly lower in both the ST36 and SP9 groups (not in the KI10 group) than in the model group (P<0.01, P<0.05), but the GRR was significantly higher in the ST36 and SP9 groups (not in the KI10 group) than in the model group (P<0.01).	Water	10-15	Sp9 transcription factor	Rattus norvegicus	178-181
34369673-12	2021	No significant differences were found between the ST36 and SP9 groups in lowering the levels of fecal water content, stool form score, SIPR, and the expression of 5-HT7R protein and mRNA, as well as in up-regulating GRR (P>0.05).	Water	102-107	Sp9 transcription factor	Rattus norvegicus	59-62
34284779-8	2021	Microscopically, glial-fibrillary acidic protein and aquaporin-4 water channel immunoreactivities were altered in the SDH pig brain.	Water	65-70	aquaporin 4	Sus scrofa	53-64
34290332-2	2021	The Luzon Strait, one of the mixing hotspots, is important for water exchange between the northeastern South China Sea and West Pacific.	Water	63-68	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	115-118
34232022-5	2021	Gaseous  OH and H2O2 generated from the oxidation of H2O and reduction of O2 by TiO2 were directly detected in the photocatalysis process, and they were identified as the determining factor for SAg-H2SO4 formation.	Water	53-56	S-antigen visual arrestin	Homo sapiens	194-197
34282684-3	2021	The objective of this study was to detect and measure pesticide concentrations in domestic tap water to estimate the risk (carcinogenic and non-carcinogenic) to health.	Water	95-100	filamin B	Homo sapiens	91-94
34282684-5	2021	The present results suggest that aldrin, heptachlor, and beta-BHC residues in domestic tap water from Ticul, Yucatan, pose a risk to children"s health, particularly for potential carcinogenic risks.	Water	91-96	filamin B	Homo sapiens	87-90
34237936-3	2021	Relaxometry and photoluminescence spectroscopy shed light on the chemical environment surrounding the metal sites, the emission properties of Eu3+, and the dynamics of interactions between Gd3+ and the inner-sphere water placed in the saponite gallery.	Water	215-220	GRDX	Homo sapiens	189-192
34322097-5	2021	Here, we explored a comprehensive profiling of microbial lipids throughout the water column of a marine euxinic basin (Black Sea) using ultra high-pressure liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HRMS/MS).	Water	79-84	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	125-128
34212653-6	2021	The NBN area exhibited the best water quality, with COD and total nitrogen concentration values of 6.9 mg L-1 and 1.82 mg L-1, respectively.	Water	32-37	nibrin	Homo sapiens	4-7
34101449-1	2021	Human norovirus (hNoV) is an important etiology of gastrointestinal illness and can be transmitted via ingestion of contaminated water.	Water	129-134	cellular communication network factor 3	Homo sapiens	17-21
34554116-6	2021	Norovirus GI/GII and other pathogens were found in human and water samples.	Water	61-66	G protein subunit alpha i1	Homo sapiens	10-16
34109728-3	2021	The water avoidance stress repeatedly applied (rWAS) is considered effective to study IBS etio-pathogenesis.	Water	4-9	WASP actin nucleation promoting factor	Rattus norvegicus	47-51
34126011-0	2021	Conjugated Cationic Pp-x Formed on g-C3N4 for Photocatalyzed Water Splitting.	Water	61-66	protein phosphatase 4 catalytic subunit	Homo sapiens	20-24
34126011-3	2021	Photocatalytic tests of Pp-x@g-C3N4 in water splitting unveiled much better Pp-x@g-C3N4 hydrogen evolution activities by comparison with both g-C3N4 and Pp-0.	Water	39-44	protein phosphatase 4 catalytic subunit	Homo sapiens	24-28
34126011-3	2021	Photocatalytic tests of Pp-x@g-C3N4 in water splitting unveiled much better Pp-x@g-C3N4 hydrogen evolution activities by comparison with both g-C3N4 and Pp-0.	Water	39-44	protein phosphatase 4 catalytic subunit	Homo sapiens	76-80
34203343-7	2021	To contain this risk, the new European directive on the quality of water intended for human consumption has introduced for the first time Legionella as a microbiological parameter to be investigated in domestic water systems.	Water	67-72	hyaluronan synthase 1	Homo sapiens	104-107
34203343-7	2021	To contain this risk, the new European directive on the quality of water intended for human consumption has introduced for the first time Legionella as a microbiological parameter to be investigated in domestic water systems.	Water	211-216	hyaluronan synthase 1	Homo sapiens	104-107
34206697-3	2021	We hypothesised that (i) soil microarthropods of the coastal tundra, including Collembola, can cross the ecosystem boundary and colonise decaying and freshly exposed macroalgae; and (ii) various inundation regimes by sea water, microhabitat stability and decaying of macroalgae drive distribution patterns of collembolan species.	Water	221-226	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	217-220
34106880-7	2021	In streptozocin-induced hyperglycemic APP/PS1/Tau triple transgenic (3xTg-AD) mice, SG-Tang also reduced expressions of NLRP1, NLRP3, Abeta and Tau in hippocampus and cortex, as well as improved working and spatial memories in Y maze and Morris water maze.	Water	245-250	presenilin 1	Mus musculus	42-45
34200281-8	2021	The new lineage of SAT-2 showed a high virulence resulting in the deaths of water buffaloes due to heart failure, confirmed by high serum levels of inflammatory and cardiac markers, including haptoglobin, ceruloplasmin, cardiac troponin I and creatine phosphokinase-MB, indicating an unfavorable FMD-infection prognosis.	Water	76-81	spermidine/spermine N1-acetyltransferase family member 2	Homo sapiens	19-24
34200281-10	2021	Furthermore, the newly identified serotype SAT-2 lib12 lineage, topotype VII, showed an aggressive pattern in water buffaloes of the smallholder production system.	Water	110-115	thialysine N-epsilon-acetyltransferase	Bubalus bubalis	43-48
34205141-8	2021	Both COF-1 and CTF-1 showed good surface properties for selective adsorption of water via hydrogen bonding and electrostatic interactions.	Water	80-85	cardiotrophin 1	Homo sapiens	15-20
34079159-3	2021	Implementing exogenous treated water quantities as an additional water supply at NUTS 2 level in the CAPRI model, we found that treated water reuse is a possible alternative supply source to address water shortages with a very negligible effect on farmers" income and food production in the EU.	Water	136-141	RAS p21 protein activator 4	Homo sapiens	101-106
34070880-6	2021	The situation in soil was similar to that in water, where low concentrations of CA contributed to the immobilization of Cd by nZVI, while high concentrations promoted the desorption of Cd and the generation of CA-Cd complexes which facilitated the uptake of Cd by plants.	Water	45-50	CACD	Homo sapiens	210-215
34113366-7	2021	Also, roc3 mutants exhibited rapid loss of water in leaf than wild type.	Water	43-48	rotamase CYP 3	Arabidopsis thaliana	6-10
34070416-2	2021	Its diuretic mechanism involves selective water reabsorption by affecting the water reabsorption receptor aquaporin 2.	Water	42-47	aquaporin 2	Homo sapiens	106-117
34070416-2	2021	Its diuretic mechanism involves selective water reabsorption by affecting the water reabsorption receptor aquaporin 2.	Water	78-83	aquaporin 2	Homo sapiens	106-117
34064081-0	2021	Association of Water Intake with Hand Grip Strength in Community-Dwelling Older Adults.	Water	15-20	glutamate receptor interacting protein 1	Homo sapiens	38-42
34064081-2	2021	This cross-sectional, population-based study using a representative sample of Koreans investigated the relationship of water intake with hand grip strength (HGS) in 4443 older adults, including 2090 men aged >=50 years and 2253 postmenopausal women.	Water	119-124	glutamate receptor interacting protein 1	Homo sapiens	142-146
34567850-5	2021	Despite stability concerns that compromise the primary catalyst reusability, CuO/cryptomelane is particularly robust in the presence of CO2 and H2O, typical components of realistic CO-PROX streams.	Water	144-147	pyruvate dehydrogenase complex component X	Homo sapiens	184-188
34567850-8	2021	In the case of CuO/cryptomelane, in spite of its lower oxygen mobility, the intrinsic structural water co-assists as active oxygen species involved in CO-PROX.	Water	97-102	pyruvate dehydrogenase complex component X	Homo sapiens	154-158
34068684-4	2021	The aim of the current translational study was to mimic a severe stress condition by exposing female CD-1 mouse dams to abnormal levels of corticosterone (80 microg/mL) in the drinking water either during the last week of pregnancy (PreCORT) or the first one of lactation (PostCORT), compared to an Animal Facility Rearing (AFR) control group.	Water	185-190	CD1 antigen complex	Mus musculus	101-105
34334929-4	2021	In this study, we use multi-objective optimization to strategically incorporate green infrastructure (GI) into water resources management plans that maximize reductions in nutrient loads, minimize stormwater runoff, and minimize costs.	Water	111-116	G protein subunit alpha i1	Homo sapiens	102-104
34164032-3	2021	To close this gap, here we used transmission electron microscopy (TEM) to study degassed water, deionized water, and gas-supersaturated water encapsulated in graphene liquid cells.	Water	136-141	gastrin	Homo sapiens	117-120
34164032-4	2021	While neither degassed water nor deionized water yielded specific features, two major microscopic structures were evident in gas-supersaturated water: (1) polycrystalline nanoparticles formed of gas molecules and (2) a high density of tiny cells.	Water	144-149	gastrin	Homo sapiens	125-128
34164032-4	2021	While neither degassed water nor deionized water yielded specific features, two major microscopic structures were evident in gas-supersaturated water: (1) polycrystalline nanoparticles formed of gas molecules and (2) a high density of tiny cells.	Water	144-149	gastrin	Homo sapiens	195-198
34164032-5	2021	Dark-field TEM imaging revealed that water molecules surrounding each cell form crystalline structures-a surprising discovery of a clathrate state in gas-supersaturated water that may help resolve several long-standing puzzles.	Water	37-42	gastrin	Homo sapiens	150-153
34164032-5	2021	Dark-field TEM imaging revealed that water molecules surrounding each cell form crystalline structures-a surprising discovery of a clathrate state in gas-supersaturated water that may help resolve several long-standing puzzles.	Water	169-174	gastrin	Homo sapiens	150-153
34164032-6	2021	Overall, this study suggests that water may form a matrix that actively interacts with gas molecules in complex and subtle ways.	Water	34-39	gastrin	Homo sapiens	87-90
34691608-5	2021	Notably, in the absence of any base, ligands and phase transfer agents, high activity (turn-over frequency, TOF, up to 107 h-1) and selectivity (>99%) for the 2,5-bisarylation of five-membered heteroarenes are achieved in water.	Water	222-227	FEZ family zinc finger 2	Homo sapiens	108-111
35537261-1	2022	In this work we present a time-resolved FTIR spectroscopic study on kinetics of atomic and molecular species, specifically CO, CN radical, N2, HCN and CO2 generated in a glow discharge of formamide-nitrogen-water mixture in a helium buffer gas.	Water	207-212	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	143-146
35429859-3	2022	A water-soluble histidine-modified perylene diimide fluorescent probe was synthesized by a one-step method, and the probe can form supramolecular aggregates in the presence of Cd2+.	Water	2-7	CD2 molecule	Homo sapiens	176-179
35152010-1	2022	The properties, structure and water holding capacity of myosin were analyzed after incubated with myoglobin (Mb) hemin prosthetic group.	Water	30-35	myosin heavy chain 14	Homo sapiens	56-62
35152010-5	2022	However, excessive oxidation would greatly reduce the physical and chemical properties of myosin, which was not conducive to the gel formation and would lead to a decrease in water retention.	Water	175-180	myosin heavy chain 14	Homo sapiens	90-96
35152018-4	2022	Under the optimized conditions, a good linearity was obtained to be 0.03-100.0 ng mL-1 for water and juice, 0.9-500 ng g-1 for tomato.	Water	91-96	L1 cell adhesion molecule	Mus musculus	82-86
35487009-12	2022	FoxO1 silencing facilitated neurological function recovery in ICH mice, evidenced by decreased mNSS, improved forelimb placement rate, reduced turning defects, declined brain water content, relieved edema, intracellular vacuoles, and inflammatory cell infiltration, and reduced IL-1beta, IL-6, and TNF-alpha levels.	Water	175-180	forkhead box O1	Mus musculus	0-5
35605542-13	2022	DISCUSSION: Results reveal pigs can potentially use AQP1, AQP5, AQP8, and AQP9 to transport water from the endometrial bloodstream to the allantoic bloodstream or allantoic fluid.	Water	92-97	AQP8	Sus scrofa	64-68
35605542-13	2022	DISCUSSION: Results reveal pigs can potentially use AQP1, AQP5, AQP8, and AQP9 to transport water from the endometrial bloodstream to the allantoic bloodstream or allantoic fluid.	Water	92-97	aquaporin 9	Sus scrofa	74-78
35593652-4	2022	Here we report equilibrium and enhanced sampling molecular dynamic simulation of the SARS-CoV-2 ORF3a in a model lipid bilayer, showing how the protein permeabilizes the lipid membrane, via the formation of a water channel, which in turn assures ion transport.	Water	209-214	ORF3a protein	Severe acute respiratory syndrome coronavirus 2	96-101
35227749-0	2022	Photocatalytic oxidation of glyphosate and reduction of Cr(VI) in water over ACF-supported CoNiWO4-gCN composite under batch and flow conditions.	Water	66-71	ACF	Homo sapiens	77-80
35227749-3	2022	Here, we report an efficient removal of glyphosate (GLP) and Cr(VI) from water under batch as well as continuous flow conditions using the activated carbon fiber (ACF)-supported nanocomposite of CoNiWO4 (CNW) and g-C3N4 (gCN), as a photocatalyst.	Water	73-78	ACF	Homo sapiens	163-166
35582984-1	2022	We characterized the anti-E2, syn-E2, inv-SN2, and ret-SN2 reaction channels for the reaction of microsolvated HO-(H2O)n anions with CH3CH2X (X = Cl, Br, I), using the CCSD(T)/PP/t//MP2/ECP/d level method, to understand how a solvent influences the competing E2 and SN2 reactions.	Water	115-118	ret proto-oncogene	Homo sapiens	51-54
35487659-5	2022	sr1 mutants which accumulate salicylic acid (SA) were found more sensitive to drought stress and showed a higher water loss rate as compared with wild-type.	Water	113-118	signal responsive 1	Arabidopsis thaliana	0-3
35487659-6	2022	By contrast, SR1-overexpression lines exhibited increased drought tolerance and less water loss than wild-type.	Water	85-90	signal responsive 1	Arabidopsis thaliana	13-16
34494839-0	2021	Exploration of Gas-Liquid Interfaces for Liquid Water and Methanol Using Extreme Ultraviolet Laser Photoemission Spectroscopy.	Water	48-53	gastrin	Homo sapiens	15-18
34494839-6	2021	On the other hand, tetrabutylammonium iodide (TBAI) and butylamine (BA) clearly reduce the VIE for liquid water, which is attributed to the formation of an electric double layer (EDL) by segregated solutes at the gas-liquid interface.	Water	106-111	gastrin	Homo sapiens	213-216
34680401-5	2021	In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology.	Water	23-28	microtubule associated protein tau	Homo sapiens	94-97
34548476-7	2021	We discovered that administration of Tf-Pep63-Lip could significantly reduce the Abeta burden in the hippocampus, and improve cognitive deficits in 6-month-old APP/PS1 mice in the Morris-Water maze task and fear-conditioning test with the combined effects of PA and Pep63.	Water	187-192	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	46-49
34594577-6	2021	Additionally, miR-485-5p overexpression facilitated the learning and memory capabilities of APP/PS1 mice according to Morris water maze test, fear conditioning test, and immunofluorescent staining.	Water	125-130	presenilin 1	Mus musculus	96-99
21993890-1	2012	The degree of water transport via aquaporin-2 (AQP2) water channels in renal collecting duct principal cells is reflected by the level of the urinary excretion of AQP2 (u-AQP2).	Water	14-19	aquaporin 2	Homo sapiens	47-51
21993890-1	2012	The degree of water transport via aquaporin-2 (AQP2) water channels in renal collecting duct principal cells is reflected by the level of the urinary excretion of AQP2 (u-AQP2).	Water	14-19	aquaporin 2	Homo sapiens	163-167
34579032-2	2021	The present study tests the hypothesis that green tea leaves in powder form (GTP), which also contain fiber and other water non-extractable materials, are more effective than the corresponding green tea extracts (GTE) in impeding the development of diabetes in db/db mice.	Water	118-123	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	50-53
21993890-1	2012	The degree of water transport via aquaporin-2 (AQP2) water channels in renal collecting duct principal cells is reflected by the level of the urinary excretion of AQP2 (u-AQP2).	Water	14-19	aquaporin 2	Homo sapiens	169-175
35597347-4	2022	The average microplastic abundance in the surface water was 0.10 +- 0.14 items/m3, with highest abundance in the Ross Sea, and the average microplastic abundance in the subsurface water was 1.66 +- 1.20 items/m3, with highest abundance in the Dumont d"Urville Sea.	Water	180-185	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	260-263
21993890-1	2012	The degree of water transport via aquaporin-2 (AQP2) water channels in renal collecting duct principal cells is reflected by the level of the urinary excretion of AQP2 (u-AQP2).	Water	53-58	aquaporin 2	Homo sapiens	34-45
22095771-2	2012	Remarkably, the activation energy relative to the reactants for the reaction of H(2)O with SO(3) is lowered through formic acid catalysis from 15.97 kcal  mol(-1) to -15.12 and -14.83 kcal  mol(-1) for the formed H(2)O   SO(3) complex plus HCOOH and the formed H(2)O   HCOOH complex plus SO(3), respectively, at the CCSD(T)//MP2/aug-cc-pv(T+d)z level.	Water	80-85	tryptase pseudogene 1	Homo sapiens	325-328
34477701-3	2021	Herein, an ultrathin citrate-Ni0.9Co0.1(OH)x (Cit-Ni0.9Co0.1(OH)x) is conformally coated on the fluorine-doped hematite (F-Fe2O3) photoanode for PEC water oxidation to simultaneously promote the internal hole extraction and surface hole injection of the target photoanode.	Water	149-154	citron rho-interacting serine/threonine kinase	Homo sapiens	46-49
22095771-2	2012	Remarkably, the activation energy relative to the reactants for the reaction of H(2)O with SO(3) is lowered through formic acid catalysis from 15.97 kcal  mol(-1) to -15.12 and -14.83 kcal  mol(-1) for the formed H(2)O   SO(3) complex plus HCOOH and the formed H(2)O   HCOOH complex plus SO(3), respectively, at the CCSD(T)//MP2/aug-cc-pv(T+d)z level.	Water	213-218	tryptase pseudogene 1	Homo sapiens	325-328
35507832-6	2022	Simultaneously, CoP/CNTHPs only needs a voltage of 1.54 V to attain a current density of 10 mA cm-2 in the electrocatalytic water splitting process, demonstrating its bifunctional activity.	Water	124-129	caspase recruitment domain family member 16	Homo sapiens	16-19
22095771-2	2012	Remarkably, the activation energy relative to the reactants for the reaction of H(2)O with SO(3) is lowered through formic acid catalysis from 15.97 kcal  mol(-1) to -15.12 and -14.83 kcal  mol(-1) for the formed H(2)O   SO(3) complex plus HCOOH and the formed H(2)O   HCOOH complex plus SO(3), respectively, at the CCSD(T)//MP2/aug-cc-pv(T+d)z level.	Water	213-218	tryptase pseudogene 1	Homo sapiens	325-328
34612280-5	2021	Microhydration suppresses fragmentation of both molecules, however in bromothiophenol, the Br- channel remains intense and Br(H2O)n- hydrated fragment clusters are observed.	Water	126-129	chromosome 12 open reading frame 73	Homo sapiens	123-125
21110210-1	2012	D: -Amino acid oxidase (DAAO) in mammal kidney regulates the renal reactive oxygen species (ROS) levels directly and plays a leading role in the development of ROS-mediated renal pathologic damages based on its crucial role in the oxidative deamination of D: -amino acids and the consequent generation of H(2)O(2).	Water	305-310	D-amino acid oxidase	Homo sapiens	0-22
34229378-6	2021	Analysis of XPS spectra of A-SmZVI post reaction with chromate indicated that multiple reductive species including Fe0, Fe(II), FeS, and S(-II) may have jointly participated in the redox reaction taking place on the A-SmZVI-water interface.	Water	224-229	transcription elongation factor A1	Homo sapiens	137-143
35446575-2	2022	After benchmarking density functional predictions of both geometries and reaction energies against jun-Cheap results for the relatively small model system HCN   (H2O)2, the best performing DFT methods are selected.	Water	162-165	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	155-158
21110210-1	2012	D: -Amino acid oxidase (DAAO) in mammal kidney regulates the renal reactive oxygen species (ROS) levels directly and plays a leading role in the development of ROS-mediated renal pathologic damages based on its crucial role in the oxidative deamination of D: -amino acids and the consequent generation of H(2)O(2).	Water	305-310	D-amino acid oxidase	Homo sapiens	24-28
34500760-0	2021	Film-Forming Spray of Water-Soluble Chitosan Containing Liposome-Coated Human Epidermal Growth Factor for Wound Healing.	Water	22-27	epidermal growth factor	Homo sapiens	78-101
22415076-2	2012	The possible participation of AQP7 to water transport was investigated in AQP7(+/+) or AQP7(-/-) mice.	Water	38-43	aquaporin 7	Mus musculus	30-34
34500760-5	2021	Therefore, this study aimed to develop a film-forming spray of water-soluble chitosan (FFSWSC) containing hEGF-liposomes as a potential wound dressing.	Water	63-68	epidermal growth factor	Homo sapiens	106-110
35628125-4	2022	Filaggrin is important for alignment of keratin intermediate filaments, control of keratinocyte shape, and maintenance of epidermal texture via production of water-retaining molecules.	Water	158-163	filaggrin	Homo sapiens	0-9
22474537-6	2012	It binds to its type-2 receptor (V2R) in the kidney induces a cAMP-driven cascade, which leads to the insertion of aquaporin-2 water channels into the apical membrane.	Water	127-132	aquaporin 2	Homo sapiens	115-126
35628747-4	2022	The biomass carbon of planktonic fungi exhibits spatiotemporal dynamics and can reach up to 1 mug CL-1 of seawater, rivaling bacteria on some occasions, which suggests their active and important role in the water column.	Water	207-212	adhesion G protein-coupled receptor L1	Homo sapiens	98-102
34532317-8	2021	The IL-6-mediated enhanced osmotic sensitivity of RA-FLS likely involves NKCC1 and aquaporin-1, which mainly constitute the volume-associated ion transporter and water channel elements.	Water	162-167	solute carrier family 12 member 2	Homo sapiens	73-78
34532317-9	2021	These results suggest that RA-FLS provide enhanced electrolytes and concomitant water movement through NKCC1 and aquaporin-1, thereby inducing cellular swelling ultimately resulting in cytotoxic edema.	Water	80-85	solute carrier family 12 member 2	Homo sapiens	103-108
23506554-6	2012	Addition of dimethylsulfoxide, but not acetonitrile, converted daidzein and cimetidine from inhibitors to activators of the ADH1C-mediated oxidation of the other substrate studied, ethanol (added in water).	Water	199-204	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	124-129
34573021-8	2021	We also observed the reduction of PC3 viability occurring following exposure to methanol and methanol/water extracts.	Water	102-107	chromobox 8	Homo sapiens	34-37
34573021-11	2021	Intriguingly, the gene expression of COX-2 and TNFalpha was reduced in PC3 cells after exposure to methanol and methanol/water extracts.	Water	121-126	chromobox 8	Homo sapiens	71-74
21352208-2	2012	Sea water intrusion is represented by the landward advance of the 10,000 mg/L iso-salinity line, a concentration of dissolved salts that renders groundwater unsuitable for human use.	Water	4-9	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
34318845-5	2021	Notably, the Ni species (Nin+) promoted the decomposition of water and produced hydrogen intermediates, which were then immediately adsorbed on the surface of Pt and recombined into molecular hydrogen.	Water	61-66	ninein	Homo sapiens	25-28
35074749-5	2022	Moreover, the percentages of Cd2+ and Zn2+ in soil pore water showed a dynamic increase in smithsonite-spiked treatments but a decrease in sphalerite-spiked treatments.	Water	56-61	CD2 molecule	Homo sapiens	29-32
35414168-3	2022	The full spectrum of alpha-Syn aggregates in the presence and absence of Cu2+ ions from monomers to mature fibrils was resolved and quantified at the gold-water interface.	Water	155-160	synuclein alpha	Homo sapiens	21-30
34578872-0	2021	Atractylodes chinensis Water Extract Ameliorates Obesity via Promotion of the SIRT1/AMPK Expression in High-Fat Diet-Induced Obese Mice.	Water	23-28	sirtuin 1	Mus musculus	78-83
22149018-1	2012	OBJECTIVE: Recent findings suggest that cerebral edema is a characteristic finding on magnetic resonance imaging in women with eclampsia and that pregnancy-induced antithrombin deficiency (PIATD) may reflect enhanced vascular permeability and may allow the retention of excess water in the interstitial space.	Water	277-282	serpin family C member 1	Homo sapiens	164-176
34485929-5	2021	Comparisons of the crystal structure of Mt-CYP11B1 to those of Wt-CYP11B1 and CYP11B2 that were already reported show that the mutation reduced the innermost space putatively surrounding the C3 side of substrate 11-deoxycorticosterone (DOC) bound to Wt-CYP11B1, while the corresponding space in CYP11B2 is enlarged markedly and accessible to bulk water through a channel.	Water	347-352	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	78-85
34485929-5	2021	Comparisons of the crystal structure of Mt-CYP11B1 to those of Wt-CYP11B1 and CYP11B2 that were already reported show that the mutation reduced the innermost space putatively surrounding the C3 side of substrate 11-deoxycorticosterone (DOC) bound to Wt-CYP11B1, while the corresponding space in CYP11B2 is enlarged markedly and accessible to bulk water through a channel.	Water	347-352	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	295-302
34485929-6	2021	Molecular dynamics simulations of their DOC-bound forms supported the above findings and revealed that the enlarged space of CYP11B2 had a hydrogen bonding network involving water molecules that position DOC.	Water	174-179	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	125-132
34502121-2	2021	Aquaporin-5 (AQP5); a water channel involved in saliva formation; is aberrantly distributed in SS SG acini and contributes to glandular dysfunction.	Water	22-27	aquaporin 5	Homo sapiens	0-11
34502121-2	2021	Aquaporin-5 (AQP5); a water channel involved in saliva formation; is aberrantly distributed in SS SG acini and contributes to glandular dysfunction.	Water	22-27	aquaporin 5	Homo sapiens	13-17
34512326-12	2021	In sum, beta-PAE improved IM in rats mainly by improving water transport and the mucus barrier, and these effects were correlated with its function on inhibiting the cAMP/PKA/CREB signaling pathway.	Water	57-62	cAMP responsive element binding protein 1	Rattus norvegicus	175-179
34502052-1	2021	The role of reactive oxygen species (ROS) in ABA-induced increase in hydraulic conductivity was hypothesized to be dependent on an increase in aquaporin water channel (AQP) abundance.	Water	153-158	HvPIP2;3	Hordeum vulgare	143-152
34451368-9	2021	Under these conditions, the highest levels of BPA removal from water were achieved and the highest adsorption capacity of MIP-2 was about 0.5 mmol g-1 (about 114.1 mg g-1) and was approximately 20% higher than for MIP-1 and NIP.	Water	63-68	C-X-C motif chemokine ligand 2	Homo sapiens	122-127
34477753-6	2021	Both BV- and BR-CDots are water-dispersible and provide fluorescence contrast, while retaining the stimuli-responsive behaviors intrinsic to their precursors.	Water	26-31	chromosome 12 open reading frame 73	Homo sapiens	13-15
34118104-4	2021	Here, we probe the structure of the central OPN fragment and its interaction with Ca 2+ and CaC 2 O 4 at the water-air interface using surface-specific non-linear vibrational spectroscopy.	Water	109-114	secreted phosphoprotein 1	Homo sapiens	44-47
34380739-1	2021	The enzyme carbonic anhydrase (CA), which catalyzes the interconversion of bicarbonate with carbon dioxide (CO2) and water, has been hypothesized to play a role in C3 photosynthesis.	Water	117-122	carbonic anhydrase, chloroplastic	Nicotiana tabacum	11-29
34497885-5	2021	In general, the outcomes indicated that superficial gas velocity had the most substantial relationship with the differential pressure fluctuations among other flotation factors (such as pump speed, superficial gas velocity, superficial water velocity, and frother dosage).	Water	236-241	gastrin	Homo sapiens	52-55
34107399-4	2021	In the optimized conditions, a good linearity was achieved within the range of 0.15-100 ng mL-1 for water sample, 1.0-100.0 ng mL-1 for tea drink samples.	Water	100-105	L1 cell adhesion molecule	Mus musculus	91-95
34107399-5	2021	The limits of detection for the analytes were 0.05-0.15 ng mL-1 for water sample and 0.30-0.50 ng mL-1 for drink samples.	Water	68-73	L1 cell adhesion molecule	Mus musculus	59-63
34492822-0	2021	A novel remediation method of cadmium (Cd) contaminated soil: Dynamic equilibrium of Cd2+ rapid release from soil to water and selective adsorption by PP-g-AA fibers-ball at low concentration.	Water	117-122	CD2 molecule	Homo sapiens	85-88
34492822-4	2021	It could remove promptly trace Cd2+ from water even in the presence of interfering metal ions.	Water	41-46	CD2 molecule	Homo sapiens	31-34
34492822-5	2021	Moreover, Cd(II) desorbed from soil to water could be continuously adsorbed by PP-g-AA fibers-ball, which kept the Cd2+ concentration always at a low level.	Water	39-44	CD2 molecule	Homo sapiens	115-118
34347487-3	2021	For the host hollow (H2O)20 cages, we have identified a most stable isomer with binding energy of -200.8 +- 2.1 kcal/mol at the CCSD(T)/CBS limit (-199.2 +- 0.5 kcal/mol at the MP2/CBS limit).	Water	21-24	tryptase pseudogene 1	Homo sapiens	177-180
34347487-4	2021	Additionally, we report converged second order Moller-Plesset (MP2) CBS binding energies for the encapsulation of guests in the (H2O)20 cage of -4.3 +- 0.1 for CH4@(H2O)20, -6.6 +- 0.1 for CO2@(H2O)20, and -8.5 +- 0.1 kcal/mol for H2S@(H2O)20, respectively.	Water	129-132	tryptase pseudogene 1	Homo sapiens	63-66
34347487-4	2021	Additionally, we report converged second order Moller-Plesset (MP2) CBS binding energies for the encapsulation of guests in the (H2O)20 cage of -4.3 +- 0.1 for CH4@(H2O)20, -6.6 +- 0.1 for CO2@(H2O)20, and -8.5 +- 0.1 kcal/mol for H2S@(H2O)20, respectively.	Water	165-168	tryptase pseudogene 1	Homo sapiens	63-66
34347487-4	2021	Additionally, we report converged second order Moller-Plesset (MP2) CBS binding energies for the encapsulation of guests in the (H2O)20 cage of -4.3 +- 0.1 for CH4@(H2O)20, -6.6 +- 0.1 for CO2@(H2O)20, and -8.5 +- 0.1 kcal/mol for H2S@(H2O)20, respectively.	Water	194-197	tryptase pseudogene 1	Homo sapiens	63-66
34347487-4	2021	Additionally, we report converged second order Moller-Plesset (MP2) CBS binding energies for the encapsulation of guests in the (H2O)20 cage of -4.3 +- 0.1 for CH4@(H2O)20, -6.6 +- 0.1 for CO2@(H2O)20, and -8.5 +- 0.1 kcal/mol for H2S@(H2O)20, respectively.	Water	236-239	tryptase pseudogene 1	Homo sapiens	63-66
34449598-0	2021	Poly (Amidehydrazide) Hydrogel Particles for Removal of Cu2+ and Cd2+ Ions from Water.	Water	80-85	CD2 molecule	Homo sapiens	65-68
34323905-2	2021	Density functional theory suggests that N2O can anchor to Co+ of (Co(N2O)(H2O)n)+ through either O end-on (eta1-OL) or N end-on (eta1-NL) coordinate mode.	Water	74-77	secreted phosphoprotein 1	Homo sapiens	107-111
34323905-2	2021	Density functional theory suggests that N2O can anchor to Co+ of (Co(N2O)(H2O)n)+ through either O end-on (eta1-OL) or N end-on (eta1-NL) coordinate mode.	Water	74-77	secreted phosphoprotein 1	Homo sapiens	129-133
34323905-5	2021	The initial activation of N2O through an electron transfer from Co+ to N2O yields anionic N2O-, which binds to the metal center of (Co2+(N2O-)(H2O)n) also through either O end-on (eta1-O) or N end-on (eta1-N) mode and is stabilized by water molecules through hydrogen bonding.	Water	143-146	secreted phosphoprotein 1	Homo sapiens	180-184
34323905-5	2021	The initial activation of N2O through an electron transfer from Co+ to N2O yields anionic N2O-, which binds to the metal center of (Co2+(N2O-)(H2O)n) also through either O end-on (eta1-O) or N end-on (eta1-N) mode and is stabilized by water molecules through hydrogen bonding.	Water	143-146	secreted phosphoprotein 1	Homo sapiens	201-205
34323905-6	2021	From eta1-O, subsequent N-O bond dissociation to liberate N2, producing (CoO(H2O)n)+, is straightforward via a mechanism that is commonplace for typical metal-catalyzed N2O decompositions.	Water	77-80	secreted phosphoprotein 1	Homo sapiens	5-9
34324804-1	2021	Au nanoparticles (Au NPs) can be self-assembled in a bottom-up orderly manner at the oil-water interface, which is widely used as SERS platforms, but the stability of the Au NP interface needs to be improved due to shaking or shifting and the Brownian motion.	Water	89-94	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	130-134
34324804-3	2021	In this study, a large area of the SERS substrate is obtained from the DNA structure-stabilized self-assembled ordered Au NPs on the cyclohexane-water interface.	Water	145-150	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	35-39
34365888-2	2022	Vitamin B12 (Vit B12) is a water soluble vitamin that is required for normal metabolism.	Water	27-32	vitrin	Rattus norvegicus	13-16
34258989-4	2021	Herein, we show that Janus In2X2X" (X and X" = S, Se, and Te) monolayers are desirable in the overall water splitting and piezoelectric devices.	Water	102-107	squalene epoxidase	Homo sapiens	50-52
34361612-3	2021	Analysis of the relaxation times tau and activation energy DeltaE of the dielectric relaxation process revealed the inhibitor was involved in hydrogen bonding and the disruption of the local structures of water molecules.	Water	205-210	microtubule associated protein tau	Homo sapiens	33-36
34360593-0	2021	Angulin-1 (LSR) Affects Paracellular Water Transport, However Only in Tight Epithelial Cells.	Water	37-42	lipolysis stimulated lipoprotein receptor	Homo sapiens	11-14
34190309-6	2021	The established heavy metal ion detector shows excellent anti-interference abilities toward the observed electroactive species, and it was successfully employed using a tap water sample for Cd2+ ion detection, where good results were observed.	Water	173-178	CD2 molecule	Homo sapiens	190-193
35319060-3	2022	1 combined with 1,8-bis(dimethylamino)naphthalene (3, proton sponge) is a Frustrated Lewis pair (FLP) that forms adducts (1-EHn-1)(3-H) with the protic compounds EHn = H2O, NH3, H2S, PH3, H2Se, HCN.	Water	168-171	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	194-197
35134220-1	2022	Understanding water use characteristics of C3 and C4 crops is important for food security under climate change.	Water	14-19	complement C4A (Rodgers blood group)	Homo sapiens	43-52
35157986-6	2022	In the Morris water maze (MWM) test, the results revealed that GP120 could induce learning and memory impairment in rats, while antagonizing NMDARs or activating CB2R could counteract GP120-induced cognitive dysfunction in rats; The results of TUNEL staining were consistent with the above results of MWM behavioral experiments.	Water	14-19	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	63-68
35157986-6	2022	In the Morris water maze (MWM) test, the results revealed that GP120 could induce learning and memory impairment in rats, while antagonizing NMDARs or activating CB2R could counteract GP120-induced cognitive dysfunction in rats; The results of TUNEL staining were consistent with the above results of MWM behavioral experiments.	Water	14-19	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	184-189
35063550-6	2022	However, bio-filtered water positively regulated the growth profile, activities of antioxidants such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), total soluble sugars, amino acids, total protein, and proline contents in wheat as compared with untreated wastewater.	Water	22-27	catalase-1	Triticum aestivum	132-140
35063550-6	2022	However, bio-filtered water positively regulated the growth profile, activities of antioxidants such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), total soluble sugars, amino acids, total protein, and proline contents in wheat as compared with untreated wastewater.	Water	22-27	catalase-1	Triticum aestivum	142-145
35063550-6	2022	However, bio-filtered water positively regulated the growth profile, activities of antioxidants such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), total soluble sugars, amino acids, total protein, and proline contents in wheat as compared with untreated wastewater.	Water	22-27	peroxidase-like	Triticum aestivum	148-158
35063550-6	2022	However, bio-filtered water positively regulated the growth profile, activities of antioxidants such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), total soluble sugars, amino acids, total protein, and proline contents in wheat as compared with untreated wastewater.	Water	22-27	peroxidase-like	Triticum aestivum	160-163
35367626-6	2022	The density of V. parahaemolyticus in shrimp rearing water was lower than that in the control at 105 CFU mL-1, especially on the 3rd day post-challenge, but there was no significant difference in the total presumptive Vibrio count between the biofloc treatment and the control.	Water	53-58	L1 cell adhesion molecule	Mus musculus	105-109
35199936-6	2022	Under the optimized separation and capture parameters, the linear range and limit of detection for Se(IV) in water sample were 0.050-200 and 0.013 mug/L, respectively.	Water	109-114	squalene epoxidase	Homo sapiens	99-105
35199936-8	2022	The developed microextraction approach was successfully utilized to detect trace Se(IV) and Se(VI) in environmental water and beer samples with satisfactory fortified recovery and repeatability.	Water	116-121	squalene epoxidase	Homo sapiens	81-87
35187613-1	2022	Post-stroke edema and upregulation of aquaporin 4 (AQP4) water transport channels play a significant role in the progression of stroke pathology and deteriorating stroke outcomes.	Water	57-62	aquaporin 4	Rattus norvegicus	38-49
35187613-1	2022	Post-stroke edema and upregulation of aquaporin 4 (AQP4) water transport channels play a significant role in the progression of stroke pathology and deteriorating stroke outcomes.	Water	57-62	aquaporin 4	Rattus norvegicus	51-55
35084714-8	2022	In addition, an increased expression of water and ion channels, including AQP3, CFTR, ENaCA, and CRISP2 was also observed which could also be inhibited by ETA.	Water	40-45	aquaporin 3 (Gill blood group)	Homo sapiens	74-78
35084714-8	2022	In addition, an increased expression of water and ion channels, including AQP3, CFTR, ENaCA, and CRISP2 was also observed which could also be inhibited by ETA.	Water	40-45	cysteine rich secretory protein 2	Homo sapiens	97-103
35484271-5	2022	The development of Mn7.5O10Br3 as an OER catalyst provides crucial insights into the design of non-noble metal electrocatalysts for water oxidation.	Water	132-137	HERC2 pseudogene 2	Homo sapiens	19-22
35474426-0	2022	Eco-friendly adsorbents based on abietic acid, boswellic acid, and chitosan/magnetite for removing waste oil from the surface of the water.	Water	133-138	ciliogenesis associated kinase 1	Homo sapiens	0-3
35384652-3	2022	Attempts have been made in this work to study the dynamic properties of water present in the vicinity of alpha-synuclein, an IDP associated with Parkinson"s disease (PD).	Water	72-77	synuclein alpha	Homo sapiens	105-120
35508095-5	2022	Under the optimal conditions, the calibration curves were linear in the range of 0.30-60.0 ng mL-1 with the determination coefficients (R2) of 0.9996-0.9998 for water samples and in the range of 0.60-60.0 ng mL-1 with the R2 values from 0.9990 to 0.9996 for beverage samples.	Water	161-166	L1 cell adhesion molecule	Mus musculus	94-98
35537882-6	2022	RESULTS: In the context of filaggrin dysfunction, the transcriptome was characterized by dysregulation of barrier function and water homeostasis, while the lesional skin of ADWt demonstrated the specific upregulation of pro-inflammatory cytokines and T-cell proliferation.	Water	127-132	filaggrin	Homo sapiens	27-36
35349993-4	2022	Polyethylene glycol diglycidyl ether (PEGDE) was the crosslinking agent of GH and Gel to solve the problem of poor mechanical properties and water solubility at 37 C. CL-CD-MOF was fabricated through a simple one-step chemical reaction to crosslink the hydrophilic hydroxyl groups in CD-MOF with diphenyl carbonate (DPC).	Water	141-146	growth hormone	Mus musculus	75-77
35479745-3	2022	Here, we show that maternal consumption of 20% (w/v) fructose water during pregnancy does not alter the metabolic balance of offspring with a chow diet, but predisposes them to obesity, fatty liver, and insulin resistance when challenged by a high-fat diet.	Water	62-67	CD36 molecule	Mus musculus	248-251
35176335-5	2022	Compared to BCl, the dissolution rates of BCl-4ABA and BCl-4HBA in water are higher but that of (B)+(26DHBA)- is lower.	Water	67-72	BCL3 transcription coactivator	Homo sapiens	55-60
34170146-2	2021	Herein, a 3D porous Tb(III)-based metal-organic framework (MOF), {(Tb(HL)(H2O)2) x(solv)}n (1), was facilely synthesized using a urea-functionalized tetracarboxylate ligand, 5,5"-(((1,4-phenylenebis(azanediyl))bis(carbonyl))bis(azanediyl))diisophthalic acid (H4L).	Water	74-77	H4 clustered histone 7	Homo sapiens	259-262
34359236-8	2021	Increased consumption of water resulted in lower urine specific gravity (p = 0.04), serum creatinine (p = 0.02), and blood urea nitrogen (p = 0.002) concentrations (without changing serum albumin, glucose, and calcium concentrations or serum osmolality) and decreased urine calcium concentration (p = 0.01) compared with cats consuming control water.	Water	25-30	albumin	Felis catus	188-195
35407326-8	2022	Additionally, the gas sensing response for 20 ppm of ethanol showed a positive dependence of doping with the manganese-doped and potassium-doped responses being 14.4% and 29.7%, respectively, higher than the pure response at 250  C. The manganese-doped and potassium-doped tungsten oxide nanowires are attractive candidates in gas sensing, photocatalytic, and energy storage applications, including water splitting, photochromism, and rechargeable batteries.	Water	399-404	gastrin	Homo sapiens	18-21
22923986-4	2012	The optimal SLN system contained a &lt;5% lipid phase and &gt;50% water phase.	Water	66-71	sarcolipin	Mus musculus	12-15
22330831-6	2012	Oral administration of 4-O-methylhonokiol through drinking water (1 mg/kg in 0.0002% Tween 80) for 12 weeks not only prevented memory impairment but also inhibited Abeta deposition.	Water	59-64	amyloid beta (A4) precursor protein	Mus musculus	164-169
35089623-4	2022	Using this central idea, we report the design and synthesis of liquid crystal-infused porous surfaces (LCIPS) and elucidate the effects of the LC mesophase on the transport and adhesion of gas bubbles on LCIPS immersed in water.	Water	222-227	gastrin	Homo sapiens	189-192
34257294-5	2021	Notably, Cpd1 has great advantages of better water solubility and rapid clearance in vivo over dantrolene.	Water	45-50	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	Mus musculus	9-13
34260384-1	2021	Subglacial water flow strongly modulates glacier basal motion, which itself strongly influences the contributions of glaciers and ice sheets to sea level rise.	Water	11-16	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	144-147
21890507-2	2012	An experiment was conducted to investigate the response of piglets receiving a water-soluble lysozyme supplement [Entegard (EG), Neova Technologies Inc., Abbotsford, British Columbia, Canada; 4,000 lysozyme units/mg] after oral challenge with enterotoxigenic Escherichia coli (ETEC).	Water	79-84	lysozyme C-3	Sus scrofa	93-101
34308029-2	2021	Based on the data obtained in this study, the pH of water samples can be calculated on the seawater pH scale as follows: pHSW = -log(K 2 e 2) + log((R - e 1)/(1 - Re 4)) where -log(K 2 e 2) = 4.981 - 0.1710S P 0.5 + 0.09428S P + 0.3794S P 1.5 + 0.0009129S P 2 + 310.2/T - 17.33S 1.5/T - 0.05895S P 1.5 ln T - 0.0005730S P 0.5 T, e 1 = 0.00049 +- 0.00029, and e 4 = -7.101 x 10-3 + 7.674 x 10-5 T + 1.361 x 10-5 S P. The term pHSW is the negative log of the hydrogen ion concentration determined on the seawater pH scale; R is the ratio of BCP absorbances (A) at 432 and 589 nm; K 2 is the equilibrium constant for the second BCP dissociation step; and e 1, e 2, and e 4 are BCP molar absorptivity ratios.	Water	52-57	small nucleolar RNA, H/ACA box 73A	Homo sapiens	153-156
34308029-2	2021	Based on the data obtained in this study, the pH of water samples can be calculated on the seawater pH scale as follows: pHSW = -log(K 2 e 2) + log((R - e 1)/(1 - Re 4)) where -log(K 2 e 2) = 4.981 - 0.1710S P 0.5 + 0.09428S P + 0.3794S P 1.5 + 0.0009129S P 2 + 310.2/T - 17.33S 1.5/T - 0.05895S P 1.5 ln T - 0.0005730S P 0.5 T, e 1 = 0.00049 +- 0.00029, and e 4 = -7.101 x 10-3 + 7.674 x 10-5 T + 1.361 x 10-5 S P. The term pHSW is the negative log of the hydrogen ion concentration determined on the seawater pH scale; R is the ratio of BCP absorbances (A) at 432 and 589 nm; K 2 is the equilibrium constant for the second BCP dissociation step; and e 1, e 2, and e 4 are BCP molar absorptivity ratios.	Water	52-57	small nucleolar RNA, H/ACA box 73A	Homo sapiens	329-332
34308029-2	2021	Based on the data obtained in this study, the pH of water samples can be calculated on the seawater pH scale as follows: pHSW = -log(K 2 e 2) + log((R - e 1)/(1 - Re 4)) where -log(K 2 e 2) = 4.981 - 0.1710S P 0.5 + 0.09428S P + 0.3794S P 1.5 + 0.0009129S P 2 + 310.2/T - 17.33S 1.5/T - 0.05895S P 1.5 ln T - 0.0005730S P 0.5 T, e 1 = 0.00049 +- 0.00029, and e 4 = -7.101 x 10-3 + 7.674 x 10-5 T + 1.361 x 10-5 S P. The term pHSW is the negative log of the hydrogen ion concentration determined on the seawater pH scale; R is the ratio of BCP absorbances (A) at 432 and 589 nm; K 2 is the equilibrium constant for the second BCP dissociation step; and e 1, e 2, and e 4 are BCP molar absorptivity ratios.	Water	52-57	small nucleolar RNA, H/ACA box 73A	Homo sapiens	652-669
35240526-7	2022	Systemic administration of eugenitol blocked Abeta aggregate-induced memory impairment in the Morris water maze test in a dose-dependent manner.	Water	101-106	amyloid beta (A4) precursor protein	Mus musculus	45-50
35278910-1	2022	A reactor accident on a nuclear submarine in Chazhma Bay (Peter the Great Bay (PGB), Japan Sea), occurred at 11:55 h local time on 10 August 1985 and caused radioactive contamination of sea water and air.	Water	190-195	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	91-94
23050123-5	2012	We designed a pair of complementary 5" UTR sequences that can link the Fab heavy and light chain genes together by overlap-extension PCR in water-in-oil emulsions.	Water	140-145	FA complementation group B	Homo sapiens	71-74
35278910-1	2022	A reactor accident on a nuclear submarine in Chazhma Bay (Peter the Great Bay (PGB), Japan Sea), occurred at 11:55 h local time on 10 August 1985 and caused radioactive contamination of sea water and air.	Water	190-195	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	186-189
35278910-3	2022	The spread of radionuclides on the sea surface in the adjacent Ussuri Bay was strongly influenced by two typhoons, which mixed the polluted water in the bay and reduced the concentration of radionuclides in the fallen spot.	Water	140-145	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	35-38
35093445-6	2022	Mice treated with PHLDA1 siRNA exhibited a lower degree of infarct volume and brain water content compared to the NC siRNA-treated mice.	Water	84-89	pleckstrin homology like domain, family A, member 1	Mus musculus	18-24
35363836-13	2022	The spatial analysis showed that the eastern part of Amhara, Afar and the Somali region predicted the highest limited drinking water services.	Water	127-132	aldo-keto reductase family 7 member A2	Homo sapiens	61-65
35086002-2	2022	AQP9 is permeable to hydrogen peroxide (H2O2) and glycerol as well as to water.	Water	73-78	aquaporin 9	Mus musculus	0-4
35358273-2	2022	Using bioinformatics tools, we selected a 12-mer tract of the CD5 mRNA as the molecular target and synthesized the complementary and control PNA strands bearing a serine phosphate dipeptide tail to enhance their water solubility and bioavailability.	Water	212-217	CD5 molecule	Homo sapiens	62-65
35293203-5	2022	Based on a comprehensive analytical investigation, we demonstrate a direct correlation of the CTF bipyridine content with the material features such as the specific surface area, band gap, charge separation, and surface wettability with water.	Water	237-242	establishment of sister chromatid cohesion N-acetyltransferase 1	Homo sapiens	94-97
35351847-4	2022	Further studies suggest that the production of covalent bonds between CA and CDs plays pivotal roles in activating LPL and preventing its quenching from oxygen and water.	Water	164-169	lipoprotein lipase	Homo sapiens	115-118
35359596-3	2022	betaB1-crystallin, which is the most abundant water-soluble protein in mammalian lens, is essential for lens transparency.	Water	46-51	crystallin beta B1	Homo sapiens	0-17
35424756-0	2022	Template free-synthesis of cobalt-iron chalcogenides (Co0.8Fe0.2L2, L = S, Se) and their robust bifunctional electrocatalysis for the water splitting reaction and Cr(vi) reduction.	Water	134-139	squalene epoxidase	Homo sapiens	75-77
35107027-2	2022	In the mouse lens, this water transport through gap junction channels generates an intracellular hydrostatic pressure gradient, which is subjected to a dual feedback regulation that is mediated by the reciprocal modulation of the transient receptor potential vanilloid channels, TRPV1 and TRPV4.	Water	24-29	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	289-294
34995943-4	2022	This emphasizes the importance of adequate BMP measures such as utilizing water diversion structures and cover management at these features to better protect water quality.	Water	158-163	bone morphogenetic protein 1	Homo sapiens	43-46
35282447-0	2022	Water Extract of Rhizoma Drynaria Selectively Exerts Estrogenic Activities in Ovariectomized Rats and Estrogen Receptor-Positive Cells.	Water	0-5	estrogen receptor 1	Rattus norvegicus	102-119
35281930-0	2022	Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Water and Sodium Metabolism.	Water	56-61	solute carrier family 5 member 2	Homo sapiens	11-41
35265075-3	2022	Increased cutaneous inflammation was associated with epithelial abnormalities, namely, altered keratinization, abnormal epidermal tight junctional morphology and increased trans-epidermal water loss; consistent with epidermal barrier dysfunction.	Water	188-193	WASP actin nucleation promoting factor	Homo sapiens	33-36
34279355-0	2021	Hollow Fiber Polyimide Membranes Prepared in a Triple Orifice Spinneret: Effect of a Reduced Water Activity in the Bore Fluid on the Gas Separation Performance.	Water	93-98	gastrin	Homo sapiens	133-136
34279355-5	2021	The bore fluid composition was explored by using water mixtures containing the solvent used for preparing the dope solution or a salt in order to reduce the water activity in the inner coagulant, but also a low amount of a crosslinker for improving the gas selectivity.	Water	49-54	gastrin	Homo sapiens	253-256
34279355-7	2021	At moderate dope flow-rates, the use of a saline water solution as bore fluid is more effective in enhancing the membrane gas selectivity with respect to a bore fluid containing certain amounts of solvent.	Water	49-54	gastrin	Homo sapiens	122-125
34302237-5	2021	Infusion of the HIV-1 gp120 protein induced memory dysfunction, which was evaluated using passive avoidance and water maze tests.	Water	112-117	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	22-27
34081286-0	2021	Correction to: A Lagrangian analysis of the gravity-inertial oil spreading on the calm sea using the reflective oil-water interface treatment.	Water	116-121	synaptosome associated protein 91	Homo sapiens	82-86
34368091-3	2021	The epithelial sodium channel (ENaC) is the rate-limiting step in the sodium-water transport and edema clearance in the alveolar cavity; the role of bone marrow-derived MSC-conditioned medium (BMSC-CM) in edema clearance and how miRNAs affect ENaC are still seldom known.	Water	77-82	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	31-35
34201808-7	2021	Compared with hot water injection, the electric heating combined with normal temperature water flooding basically shows the same promotion effect on gas recovery.	Water	18-23	gastrin	Homo sapiens	149-152
34201808-7	2021	Compared with hot water injection, the electric heating combined with normal temperature water flooding basically shows the same promotion effect on gas recovery.	Water	89-94	gastrin	Homo sapiens	149-152
34115510-7	2021	When a value approximately equal to the a of POPC bilayers was assigned to acp, the resultant Pi-a profile partially or approximately completely overlapped with the Pi-a isotherms obtained for the monolayers at the air-water interface using a Langmuir trough.	Water	219-224	RPTOR independent companion of MTOR complex 2	Homo sapiens	94-98
34156031-0	2021	Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting.	Water	40-45	programmed cell death 10	Mus musculus	0-6
34156031-4	2021	Here, we found that mice deficient of Pdcd10 or Stk24/25 in the kidney tubules developed polyuria and displayed increased water consumption.	Water	122-127	programmed cell death 10	Mus musculus	38-44
34156031-8	2021	Our current study identified the PDCD10-STK-ERM signaling pathway as a potentially novel pathway required for water balance control by regulating vesicle trafficking and protein abundance of AQP2 in the kidneys.	Water	110-115	programmed cell death 10	Mus musculus	33-39
34156031-8	2021	Our current study identified the PDCD10-STK-ERM signaling pathway as a potentially novel pathway required for water balance control by regulating vesicle trafficking and protein abundance of AQP2 in the kidneys.	Water	110-115	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	Mus musculus	40-43
34156031-8	2021	Our current study identified the PDCD10-STK-ERM signaling pathway as a potentially novel pathway required for water balance control by regulating vesicle trafficking and protein abundance of AQP2 in the kidneys.	Water	110-115	aquaporin 2	Mus musculus	191-195
34121627-6	2021	As per previous studies, a set of invariant water (IW) molecules of MMP-1 (a collagenase) play a significant role in stabilizing their catalytic domain.	Water	44-49	matrix metallopeptidase 1	Homo sapiens	68-88
34198808-3	2021	The aim of this work was to develop and validate a fast and reliable methodology to screen seven VMSs in water samples, by headspace solid-phase microextraction (HS-SPME) followed by gas chromatography with flame ionization detection (GC-FID).	Water	105-110	gastrin	Homo sapiens	183-186
34282660-0	2021	Household Water Insecurity Affects Child Nutrition Through Alternative Pathways to WASH: Evidence From India.	Water	10-15	WASP family homolog 6, pseudogene	Homo sapiens	83-87
34282660-4	2021	Water-related mechanisms outside of the traditional scope of WASH might assist with explaining this.	Water	0-5	WASP family homolog 6, pseudogene	Homo sapiens	61-65
34073361-6	2021	Furthermore, the method developed for loading of the microgel particles with CBD in ethanol was further improved by a subsequent transfer of the loaded particles into water, which proves to be an even more promising approach due to the successful temperature-dependent release of the drug above the collapse temperature of the microgels.	Water	167-172	opsin 1, medium wave sensitive	Homo sapiens	77-80
34108949-10	2021	In addition, the Class I integron (intI1) genes were detected in high amounts at all sites and all sampling points, and were about ~20 times higher in the downstream sites (2.5 x 107 copies/100 mL surface water) compared to the upstream sites (1.2 x 106 copies/100 mL surface water).	Water	205-210	IntI1	Escherichia coli	17-40
34108949-10	2021	In addition, the Class I integron (intI1) genes were detected in high amounts at all sites and all sampling points, and were about ~20 times higher in the downstream sites (2.5 x 107 copies/100 mL surface water) compared to the upstream sites (1.2 x 106 copies/100 mL surface water).	Water	276-281	IntI1	Escherichia coli	17-40
34095669-0	2021	Zero-Order Controlled Release of Water-Soluble Drugs Using a Marker Pen Platform.	Water	33-38	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	68-71
34095669-3	2021	Inspired by the marker pen, which stores the water-based ink in the sponge core and releases a constant amount of ink from the tip for writing, we explore the marker pen as a drug delivery platform to achieve zero-order release of water-soluble drugs.	Water	45-50	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	23-26
34095669-3	2021	Inspired by the marker pen, which stores the water-based ink in the sponge core and releases a constant amount of ink from the tip for writing, we explore the marker pen as a drug delivery platform to achieve zero-order release of water-soluble drugs.	Water	45-50	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	166-169
34095669-3	2021	Inspired by the marker pen, which stores the water-based ink in the sponge core and releases a constant amount of ink from the tip for writing, we explore the marker pen as a drug delivery platform to achieve zero-order release of water-soluble drugs.	Water	231-236	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	23-26
34095669-3	2021	Inspired by the marker pen, which stores the water-based ink in the sponge core and releases a constant amount of ink from the tip for writing, we explore the marker pen as a drug delivery platform to achieve zero-order release of water-soluble drugs.	Water	231-236	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	166-169
34095669-4	2021	Through the capillary interaction between the material and water, the pen core can absorb the aqueous drug solution to encapsulate and store the water-soluble drug model sodium fluorescein (SF) and can release the encapsulated SF by moving the pen tip across the surface.	Water	59-64	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	70-73
34095669-4	2021	Through the capillary interaction between the material and water, the pen core can absorb the aqueous drug solution to encapsulate and store the water-soluble drug model sodium fluorescein (SF) and can release the encapsulated SF by moving the pen tip across the surface.	Water	59-64	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	244-247
34095669-4	2021	Through the capillary interaction between the material and water, the pen core can absorb the aqueous drug solution to encapsulate and store the water-soluble drug model sodium fluorescein (SF) and can release the encapsulated SF by moving the pen tip across the surface.	Water	145-150	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	70-73
34095684-6	2021	One tetramer structure of hBD-3 was predicted by running all-atom MD simulations on hBD-3 in water at a high concentration, which was found to be stable in water during 400 ns all-atom simulations based on root-mean-squared deviation, root-mean-squared fluctuation, buried surface area, and binding interaction energy calculations.	Water	93-98	defensin beta 103B	Homo sapiens	26-31
34095684-6	2021	One tetramer structure of hBD-3 was predicted by running all-atom MD simulations on hBD-3 in water at a high concentration, which was found to be stable in water during 400 ns all-atom simulations based on root-mean-squared deviation, root-mean-squared fluctuation, buried surface area, and binding interaction energy calculations.	Water	93-98	defensin beta 103B	Homo sapiens	84-89
34095684-6	2021	One tetramer structure of hBD-3 was predicted by running all-atom MD simulations on hBD-3 in water at a high concentration, which was found to be stable in water during 400 ns all-atom simulations based on root-mean-squared deviation, root-mean-squared fluctuation, buried surface area, and binding interaction energy calculations.	Water	156-161	defensin beta 103B	Homo sapiens	26-31
34374234-7	2021	(4) Classical water maze experiment: the escape latency of APP/PS1/tau+Vehicle group mice on the 4th and 5th days was significantly longer than that of C57+Vehicle group mice (P<0.01), which was markedly shortened after B-GOS intervention (P<0.05).	Water	14-19	presenilin 1	Mus musculus	63-66
34467289-0	2021	The Gas Diffusion Electrode Setup as Straightforward Testing Device for Proton Exchange Membrane Water Electrolyzer Catalysts.	Water	97-102	gastrin	Homo sapiens	4-7
34164032-0	2021	Investigating states of gas in water encapsulated between graphene layers.	Water	31-36	gastrin	Homo sapiens	24-27
34164032-1	2021	Conventionally, only two states are assumed to exist in water: well-dispersed gas monomers and gas bubbles.	Water	56-61	gastrin	Homo sapiens	78-81
34164032-1	2021	Conventionally, only two states are assumed to exist in water: well-dispersed gas monomers and gas bubbles.	Water	56-61	gastrin	Homo sapiens	95-98
34719652-7	2021	Repeated intracerebroventricular administration of the specific TRPV4 antagonists HC-067047 and RN-1734 dose-dependently reduced brain water content and alleviated EB extravasation in FPI mice.	Water	135-140	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	64-69
34238461-2	2021	In the renal collecting duct, vasopressin binds to the V2 receptor, increasing water permeability through activation of aquaporin-2 redistribution to the luminal membrane.	Water	79-84	aquaporin 2	Homo sapiens	120-131
35113544-3	2022	The self-assembly of this molecule in water created assemblies with inner spaces due to the steric effect, which suppressed aromatic interactions of PDI and trapped water for the colloidal stability.	Water	38-43	peptidyl arginine deiminase 1	Homo sapiens	149-152
35113544-4	2022	By replacing POSS with dodecyl (C12), C12-PDI-C12 aggregated with extended aromatic interaction of PDI and less inner water.	Water	118-123	peptidyl arginine deiminase 1	Homo sapiens	38-45
35138533-0	2022	Removal of Cd2+ from water containing Ca2+ and Mg2+ using titanate nanotubes modified by carbon.	Water	21-26	CD2 molecule	Homo sapiens	11-14
35138533-2	2022	When Cd2+ is removed from water by adsorption, it will be inhibited by these two ions.	Water	26-31	CD2 molecule	Homo sapiens	5-8
35138533-8	2022	But when there is 0.1 M Ca2+ or Mg2+ in the water, the order of Cd2+ adsorption capacity becomes TNT/HC (44.28, 49.04 mg/g) > TNT/C (58.84, 69.32 mg/g) > TNT (65.52, 70.6 mg/g).	Water	44-49	CD2 molecule	Homo sapiens	64-67
35138533-12	2022	The results of this paper can provide ideas for the adsorption and removal of Cd2+ in water in the presence of Ca2+ or Mg2+.	Water	86-91	CD2 molecule	Homo sapiens	78-81
35081609-0	2022	An ab initio study of two-dimensional anisotropic monolayers ScXY (X = S and Se; Y = Cl and Br) for photocatalytic water splitting applications with high carrier mobilities.	Water	115-120	chromosome 12 open reading frame 73	Homo sapiens	92-94
34819404-2	2021	Actively boiling hot spring water contained >1x104 microbes mL-1.	Water	28-33	L1 cell adhesion molecule	Mus musculus	60-64
22467030-5	2012	No changes in the ChE-inhibiting activities were observed for carbamate pesticide solutions tested before and after chlorination, but an additive effect showed against ChE when these compounds were mixed with paraoxon in water.	Water	221-226	butyrylcholinesterase	Homo sapiens	168-171
35084406-0	2022	Two-dimensional CdS/SnS2 heterostructure: a highly efficient direct Z-scheme water splitting photocatalyst.	Water	77-82	CDP-diacylglycerol synthase 1	Homo sapiens	16-19
35084406-2	2022	In this work, we propose a two-dimensional CdS/SnS2 heterostructure (CSHS) as a possible water splitting photocatalyst by first-principles calculations.	Water	89-94	CDP-diacylglycerol synthase 1	Homo sapiens	43-46
22467030-6	2012	This combination of oxidative derivatization and ChE inhibition assay was applied successfully to the detection and determination of ChE inhibitors in natural and drinking water samples.	Water	172-177	butyrylcholinesterase	Homo sapiens	49-52
35429939-2	2022	CSK group had higher water/fat retention capacity, but similar gel strength and color distribution compared with normal salt addition.	Water	21-26	C-terminal Src kinase	Gallus gallus	0-3
22467030-6	2012	This combination of oxidative derivatization and ChE inhibition assay was applied successfully to the detection and determination of ChE inhibitors in natural and drinking water samples.	Water	172-177	butyrylcholinesterase	Homo sapiens	133-136
35080892-6	2022	The GaMD US/dual-water approach is tested on the 1D Potential of Mean Force (PMF) of the solvated CD2-CD58 system (168 000 atoms), allowing the AMOEBA PMF to converge within 1 kcal/mol of the experimental value.	Water	17-22	CD2 molecule	Homo sapiens	98-101
22426727-0	2012	Molecular modeling of lipase binding to a substrate-water interface.	Water	52-57	PAN0_003d1715	Moesziomyces antarcticus	22-28
35472551-8	2022	CSCF exhibited good photocatalytic degradation performance in a broad range of ionic strengths, in the presence of common coexisting ions including Cl-, NO3- and SO42-, in a wide range of pH (5-11), and in real water samples including tap water, river water and lake water.	Water	211-216	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	0-4
35472551-8	2022	CSCF exhibited good photocatalytic degradation performance in a broad range of ionic strengths, in the presence of common coexisting ions including Cl-, NO3- and SO42-, in a wide range of pH (5-11), and in real water samples including tap water, river water and lake water.	Water	239-244	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	0-4
35472551-8	2022	CSCF exhibited good photocatalytic degradation performance in a broad range of ionic strengths, in the presence of common coexisting ions including Cl-, NO3- and SO42-, in a wide range of pH (5-11), and in real water samples including tap water, river water and lake water.	Water	252-257	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	0-4
35472551-8	2022	CSCF exhibited good photocatalytic degradation performance in a broad range of ionic strengths, in the presence of common coexisting ions including Cl-, NO3- and SO42-, in a wide range of pH (5-11), and in real water samples including tap water, river water and lake water.	Water	267-272	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	0-4
35113000-10	2022	Downregulation of MALAT1 inhibited the neurological scores, brain water content, and neuronal apoptosis, reduced the levels of pro-inflammatory cytokines, and prevented oxidative stress in ICH rats.	Water	66-71	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	18-24
35472551-10	2022	CSCF has potential applications to treat water with either PCT or BPA contamination.	Water	41-46	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	0-4
22426727-1	2012	Interactions of lipases with hydrophobic substrate-water interfaces are of great interest to design improved lipase variants and engineer reaction conditions.	Water	51-56	PAN0_003d1715	Moesziomyces antarcticus	16-22
22426727-2	2012	This chapter describes the necessary steps to carry out molecular dynamics simulations of Candida antarctica lipase B at tributyrin-water interface using the GROMACS simulation software.	Water	132-137	PAN0_003d1715	Moesziomyces antarcticus	109-115
35018917-2	2022	Reaction of ZrCl4 with H3pidiox in methanol gives the mononuclear compound (ZrIV(eta1,eta1,eta2-H2pidiox-O,N,O")2(OH2)2)Cl2 H2O CH3OH (1), while the same reaction mixture in the presence of KOH gave the pentanuclear ZrOC (ZrIV5(mu2-OH)4(OH2)4(mu2-eta1,eta1,eta2-Hpidiox-O,N,O")4(eta1,eta1,eta1-HpidioxO,N,O")4) 5KCl 3CH3OH 8H2O (2).	Water	124-127	secreted phosphoprotein 1	Homo sapiens	81-85
35018917-2	2022	Reaction of ZrCl4 with H3pidiox in methanol gives the mononuclear compound (ZrIV(eta1,eta1,eta2-H2pidiox-O,N,O")2(OH2)2)Cl2 H2O CH3OH (1), while the same reaction mixture in the presence of KOH gave the pentanuclear ZrOC (ZrIV5(mu2-OH)4(OH2)4(mu2-eta1,eta1,eta2-Hpidiox-O,N,O")4(eta1,eta1,eta1-HpidioxO,N,O")4) 5KCl 3CH3OH 8H2O (2).	Water	124-127	secreted phosphoprotein 1	Homo sapiens	86-90
21489808-4	2011	Taking the water phantom irradiated with the BNCT facility at the Tsing Hua Open-pool Reactor (THOR) as an example, the (6)LiF concentration for TLD-700 is 0.007%, the magnitude of the neutron flux is ~1x10(9) n/cm(2)/s, the neutron energy is ~4x10(-7) MeV (cadmium cut-off energy), the gamma dose rate is ~3 Gy/h, thus the percentage error can be predicted as 38%.	Water	11-16	LIF interleukin 6 family cytokine	Homo sapiens	123-126
35018917-2	2022	Reaction of ZrCl4 with H3pidiox in methanol gives the mononuclear compound (ZrIV(eta1,eta1,eta2-H2pidiox-O,N,O")2(OH2)2)Cl2 H2O CH3OH (1), while the same reaction mixture in the presence of KOH gave the pentanuclear ZrOC (ZrIV5(mu2-OH)4(OH2)4(mu2-eta1,eta1,eta2-Hpidiox-O,N,O")4(eta1,eta1,eta1-HpidioxO,N,O")4) 5KCl 3CH3OH 8H2O (2).	Water	124-127	secreted phosphoprotein 1	Homo sapiens	247-251
35018917-2	2022	Reaction of ZrCl4 with H3pidiox in methanol gives the mononuclear compound (ZrIV(eta1,eta1,eta2-H2pidiox-O,N,O")2(OH2)2)Cl2 H2O CH3OH (1), while the same reaction mixture in the presence of KOH gave the pentanuclear ZrOC (ZrIV5(mu2-OH)4(OH2)4(mu2-eta1,eta1,eta2-Hpidiox-O,N,O")4(eta1,eta1,eta1-HpidioxO,N,O")4) 5KCl 3CH3OH 8H2O (2).	Water	124-127	secreted phosphoprotein 1	Homo sapiens	252-256
35018917-2	2022	Reaction of ZrCl4 with H3pidiox in methanol gives the mononuclear compound (ZrIV(eta1,eta1,eta2-H2pidiox-O,N,O")2(OH2)2)Cl2 H2O CH3OH (1), while the same reaction mixture in the presence of KOH gave the pentanuclear ZrOC (ZrIV5(mu2-OH)4(OH2)4(mu2-eta1,eta1,eta2-Hpidiox-O,N,O")4(eta1,eta1,eta1-HpidioxO,N,O")4) 5KCl 3CH3OH 8H2O (2).	Water	124-127	secreted phosphoprotein 1	Homo sapiens	279-283
35018917-2	2022	Reaction of ZrCl4 with H3pidiox in methanol gives the mononuclear compound (ZrIV(eta1,eta1,eta2-H2pidiox-O,N,O")2(OH2)2)Cl2 H2O CH3OH (1), while the same reaction mixture in the presence of KOH gave the pentanuclear ZrOC (ZrIV5(mu2-OH)4(OH2)4(mu2-eta1,eta1,eta2-Hpidiox-O,N,O")4(eta1,eta1,eta1-HpidioxO,N,O")4) 5KCl 3CH3OH 8H2O (2).	Water	124-127	secreted phosphoprotein 1	Homo sapiens	284-288
35526481-2	2022	Cadmium ion (Cd2+) as a hazardous water pollutant is seriously detrimental to human health, food safety, and ecological areas.	Water	34-39	CD2 molecule	Homo sapiens	13-16
35526481-7	2022	The aptasensor could detect Cd2+ in the diverse real sample, including tap water, milk, coffee, and human blood serum.	Water	75-80	CD2 molecule	Homo sapiens	28-31
35569167-0	2022	Stomatal closure induced by hydrogen-rich water is dependent on GPA1 in Arabidopsis thaliana.	Water	42-47	G protein alpha subunit 1	Arabidopsis thaliana	64-68
35569167-3	2022	Here, we estimated a possible role of Arabidopsis GPA1 in hydrogen-rich water (HRW)-induced stomatal closure.	Water	72-77	G protein alpha subunit 1	Arabidopsis thaliana	50-54
35018917-2	2022	Reaction of ZrCl4 with H3pidiox in methanol gives the mononuclear compound (ZrIV(eta1,eta1,eta2-H2pidiox-O,N,O")2(OH2)2)Cl2 H2O CH3OH (1), while the same reaction mixture in the presence of KOH gave the pentanuclear ZrOC (ZrIV5(mu2-OH)4(OH2)4(mu2-eta1,eta1,eta2-Hpidiox-O,N,O")4(eta1,eta1,eta1-HpidioxO,N,O")4) 5KCl 3CH3OH 8H2O (2).	Water	124-127	secreted phosphoprotein 1	Homo sapiens	289-293
22101597-1	2011	BET 1: prophylactic antibiotic use to prevent Weil"s disease after immersion in water.	Water	80-85	Bet1 golgi vesicular membrane trafficking protein	Homo sapiens	0-5
22196765-5	2011	RESULTS: APP/PS1 mice treated with BMSCs performed significantly better on the water maze test than those in sham-operated group (P<0 05).	Water	79-84	presenilin 1	Mus musculus	13-16
35272120-1	2022	In order to remove the organic pollution from water environment, Co2+-doped ZnO nanoarray photocatalyst was prepared through a hydrothermal process.	Water	46-51	complement C2	Homo sapiens	65-68
24278581-0	2011	Four-Week Repeated Oral Toxicity Study of AIP1, a Water-soluble Carbohydrate Fraction from Artemisia iwayomogi in Mice.	Water	50-55	membrane associated guanylate kinase, WW and PDZ domain containing 2	Mus musculus	42-46
35182527-6	2022	This research elaborates a simplistic, and reliable preconcentration column method highly developed for the determination of Cd2+, Fe3+, Co2+, Cr3+, Cu2+, Mn2+, Pb2+ and Ni2+ ions in model solutions and real water samples by flame atomic absorption spectrometry (FAAS).	Water	208-213	CD2 molecule	Homo sapiens	125-128
24278581-2	2011	AIP1, a water-soluble carbohydrate fraction from Artemisia iwayomogi, showed anti-tumor and immuno-modulating activities in animal studies.	Water	8-13	membrane associated guanylate kinase, WW and PDZ domain containing 2	Mus musculus	0-4
22127059-3	2011	Here we show the pressure-induced formation of a partially ionic phase (monoclinic P2(1) structure) consisting of coupled alternate layers of (OH)(delta-) and (H(3)O)(delta+) (delta=0.62) in water ice predicted by particle-swarm optimization structural search at zero temperature and pressures of &gt;14 Mbar.	Water	191-196	H3 histone pseudogene 16	Homo sapiens	83-88
35367668-5	2022	We describe a novel effect of FGF19, namely the stimulation of water intake.	Water	63-68	fibroblast growth factor 15	Mus musculus	30-35
35367274-5	2022	In the process of forming hDES, the removal rate of liquid hot water lignin (LHWL) was reached 99%.	Water	63-68	desmin	Homo sapiens	26-30
21897936-0	2011	Microsolvation of Co2+ and Ni2+ by acetonitrile and water: photodissociation dynamics of M(2+)(CH3CN)n(H2O)m. The microsolvation of cobalt and nickel dications by acetonitrile and water is studied by measuring photofragment spectra at 355, 532 and 560-660 nm.	Water	52-57	complement C2	Homo sapiens	18-21
35624485-15	2022	Furthermore, the ROS/ TXNIP/ HIF-1alpha pathway was shown to mediate the therapeutic effect of melatonin in EAU.	Water	108-111	hypoxia inducible factor 1, alpha subunit	Mus musculus	29-39
22070293-15	2011	In conclusion, the IPSp/Tree method is a potentially fast and sufficiently accurate technique for predicting transport coefficients and liquid structures of water in a homogeneous system.	Water	157-162	inositol-3-phosphate synthase 1	Homo sapiens	19-23
35636226-1	2022	Aquaporin 4 (AQP4), a water channel protein, has been well studied in arterial stroke-induced brain edema.	Water	22-27	aquaporin 4	Rattus norvegicus	0-11
35636226-1	2022	Aquaporin 4 (AQP4), a water channel protein, has been well studied in arterial stroke-induced brain edema.	Water	22-27	aquaporin 4	Rattus norvegicus	13-17
22031316-7	2011	Pick up of floaters from the water bath appears most common (~60%).	Water	29-34	protein interacting with PRKCA 1	Homo sapiens	0-4
35636290-0	2022	Molten salt-induced vertical CoP/Co nanosheets array coupled with carbon for efficient water splitting.	Water	87-92	caspase recruitment domain family member 16	Homo sapiens	29-32
35150992-6	2022	At the same time, Li element exists in the form of Li2CO3, LiF and aluminum-lithium compound that can be recycled by water-leaching in the water impact crushing process while transition metals can be recycled by acid leaching without reducing agents.	Water	139-144	LIF interleukin 6 family cytokine	Homo sapiens	59-62
21868635-9	2011	The results suggest that bisacodyl may decrease the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect.	Water	100-105	aquaporin 3 (Gill blood group)	Homo sapiens	66-70
35567361-2	2022	Co@Mn 3 O 4 nanocubes can efficiently photo-reduce CO 2 to CO with a remarkable turnover number of 581.8 using (Ru(bpy) 3 )Cl 2  6H 2 O as photosensitizer and triethanolamine as sacrificial agent in acetonitrile and water.	Water	216-221	complement C2	Homo sapiens	51-55
21868089-2	2011	In this investigation, water vapor sorption and the role of hydration on the molecular chain dynamics and viscoelastic properties of resilin-mimetic protein, rec1-resilin is investigated in detail.	Water	23-28	RAD1 checkpoint DNA exonuclease	Homo sapiens	158-162
21868089-6	2011	From the comparison between the absorption and desorption isotherms at a constant water activity, it has been observed that rec1-resilin exhibits sorption hysteresis only for the tightly bound water.	Water	82-87	RAD1 checkpoint DNA exonuclease	Homo sapiens	124-128
35534498-3	2022	The transport of aquaporin 2 between membrane and storage region is a crucial part of the water reabsorption in renal principal cells, and its malfunction can lead to Diabetes insipidus.	Water	90-95	aquaporin 2	Homo sapiens	17-28
21868089-6	2011	From the comparison between the absorption and desorption isotherms at a constant water activity, it has been observed that rec1-resilin exhibits sorption hysteresis only for the tightly bound water.	Water	193-198	RAD1 checkpoint DNA exonuclease	Homo sapiens	124-128
21849984-4	2011	Our results revealed that water maze training significantly decreased laminin-beta1 (LB1) expression in the rat hippocampal CA1 area.	Water	26-31	laminin subunit beta 1	Rattus norvegicus	70-83
35624611-2	2022	Therefore, it is critical to develop a sensitive and simple method for rapidly detecting Cd2+ in water samples.	Water	97-102	CD2 molecule	Homo sapiens	89-92
35624611-3	2022	Herein, an enzymic membrane was developed based on an easy and rapid immobilization method of horseradish peroxidase (HRP), for determination of Cd2+ in drinking water.	Water	162-167	CD2 molecule	Homo sapiens	145-148
35624611-8	2022	The use of this enzymic membrane proved to be advantageous when reversible inhibitors such as the copper ion (Cu2+) were present in water samples, as Cu2+ can interfere with Cd2+ and cause erroneous results.	Water	132-137	CD2 molecule	Homo sapiens	174-177
35508898-0	2022	Separator-Wetted, Acid- and Water-Scavenged Electrolyte with Optimized Li-Ion Solvation to Form Dual Efficient Electrode Electrolyte Interphases via Hexa-Functional Additive.	Water	28-33	hexosaminidase subunit alpha	Homo sapiens	149-153
35430812-3	2022	Guanidine hydrochloride (GdnHCl) denaturation experiments reveal that the unfolding free energy, DeltaGu "(H2O), of UBA(1) is 2.4 kcal mol-1.	Water	107-110	ubiquitin like modifier activating enzyme 1	Homo sapiens	116-121
35140128-5	2022	In the Lung Water by Ultra-Sound Guided Treatment to Prevent Death and Cardiovascular Complications in High Risk Kidney Failure Patients with Cardiomyopathy (LUST) trial, a treatment strategy guided by lung ultrasound safely relieved lung congestion but failed to significantly reduce the risk for a combined end point including death, nonfatal myocardial infarction, and decompensated heart failure.	Water	12-17	RBM5 antisense RNA 1	Homo sapiens	158-162
35042030-4	2022	EXPERIMENTS: Surface tension, ST, neutron reflectivity, NR, and small angle neutron scattering, SANS, have been used here to explore the synergistic mixing in micelles and at the air-water interface for the zwitterionic surfactant, dodecyldimethylammonium propanesulfonate, C12SB, and the anionic surfactants, alkyl ester sulfonate, AES, in the absence and presence of electrolyte, 0.1 M NaCl.	Water	183-188	USH1 protein network component sans	Homo sapiens	96-100
35065439-0	2022	A high efficiency water hydrogen production method based on CdS/WN composite photocatalytic.	Water	18-23	CDP-diacylglycerol synthase 1	Homo sapiens	60-63
35065439-6	2022	This study provides a novel and cost-effective approach for designing efficient noble-metal-free photocatalysts and improving H2 evolution activity of CdS under visible-light-driven photocatalytic water splitting.	Water	197-202	CDP-diacylglycerol synthase 1	Homo sapiens	151-154
35066234-4	2022	Herein, a facile in-situ photodeposition strategy has been developed to grow CdS nanocrystals on MnO2-x nanorods with rich oxygen vacancies (VO) as a direct Z-scheme photocatalyst for boosting water oxidation.	Water	193-198	CDP-diacylglycerol synthase 1	Homo sapiens	77-80
35066982-2	2022	OBJECTIVES: To evaluate the effectiveness of an EGF-containing cream on PIH, post-laser erythema, and transepidermal water loss (TEWL) after 1,064-nm Q-Switched Nd: YAG laser treatment of Hori"s nevus.	Water	117-122	epidermal growth factor	Homo sapiens	48-51
35216518-6	2022	The reduced water reabsorption appears to be mediated by atrial natriuretic peptide (ANP) because SCI increased the expression levels of both ANP and natriuretic peptide receptor A (NPR-A) in the kidney cortex.	Water	12-17	natriuretic peptide type A	Mus musculus	57-83
35477958-3	2022	24-11 ka) with its tremendous water level drop of ~ 240 m that finally led to its transition into the present hypersaline water body-the Dead Sea.	Water	30-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	142-145
35477958-3	2022	24-11 ka) with its tremendous water level drop of ~ 240 m that finally led to its transition into the present hypersaline water body-the Dead Sea.	Water	122-127	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	142-145
35571779-1	2022	Alcohol-water solution-mediated transformation of gypsum into alpha-hemihydrate (alpha-HH) whiskers provides a green alternative for the high-value-added recycling of flue gas desulfurization (FGD) gypsum.	Water	8-13	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	81-89
35449226-4	2022	However, quadrupedal water launch has never been demonstrated in smaller pterosaurs, including those living around the Tethys Sea in the Late Jurassic Solnhofen Lagoon.	Water	21-26	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	126-129
35590868-2	2022	The adsorption of furan, C8H10 (p-xylene), and H2O on pristine GP and S- and Si-doped GP are investigated using the density functional theory (DFT) calculation.	Water	47-50	ring finger protein 130	Homo sapiens	63-65
35590868-2	2022	The adsorption of furan, C8H10 (p-xylene), and H2O on pristine GP and S- and Si-doped GP are investigated using the density functional theory (DFT) calculation.	Water	47-50	ring finger protein 130	Homo sapiens	86-88
35512588-5	2022	Moreover, in the HER and OER couple system (HER  OER), the optimal O-CoP-40 catalyst delivers a low overpotential of only 1.54 V to obtain the 10 mA cm-2 and stably-running for 36 h. Theoretical calculations demonstrated that the electron-rich P-3p and O-2p orbitals could co-modulate the electronic environment of Co sites, which boosted water dissociation in the HER process and balanced the adsorption/desorption of intermediates in the OER pathway, resulting in a good overall water splitting.	Water	339-344	caspase recruitment domain family member 16	Homo sapiens	69-72
35512588-5	2022	Moreover, in the HER and OER couple system (HER  OER), the optimal O-CoP-40 catalyst delivers a low overpotential of only 1.54 V to obtain the 10 mA cm-2 and stably-running for 36 h. Theoretical calculations demonstrated that the electron-rich P-3p and O-2p orbitals could co-modulate the electronic environment of Co sites, which boosted water dissociation in the HER process and balanced the adsorption/desorption of intermediates in the OER pathway, resulting in a good overall water splitting.	Water	481-486	caspase recruitment domain family member 16	Homo sapiens	69-72
35447164-7	2022	For instance, central infusion of IL-1beta or TNF-alpha can directly affect sodium and water consumption in animal models.	Water	87-92	interleukin 1 alpha	Homo sapiens	34-42
35559206-4	2022	Unexpectedly, QPAF(C4)-4 showed a higher water uptake and a lower bulk/surface conductivity than QPAF(C6)-4 possibly due to the decrease in hydrophobicity with a smaller number of fluorine atoms.	Water	41-46	complement C4A (Rodgers blood group)	Homo sapiens	14-24
35404034-1	2022	The work reports a modeling analysis of single-compound and binary adsorption of Pb2+ and Cd2+ ions from polluted water onto the activated carbon at room temperature.	Water	114-119	CD2 molecule	Homo sapiens	90-93
35458309-4	2022	The effectiveness of this composite as a water purification fixed-bed filter was optimized in a batch system for the removal of cadmium (Cd+2) and lead (Pb+2) ions, and additionally characterized for its antimicrobial and antifungal properties and cytotoxicity effect.	Water	41-46	CD2 molecule	Homo sapiens	137-141
35447848-7	2022	Treatment with Heberprot-P75  induced greater embryo development speed with a higher survival rate after exposure to EGF in water and microinjection into embryos.	Water	124-129	epidermal growth factor	Danio rerio	117-120
35170133-2	2022	To address this issue, a series of cyclometalated Ir(III) complexes ( Ir1 - Ir5 ), featuring different electron-donating substituents to enhance the absorptivity, have been synthesized and studied as photosensitizers (PSs) for light-driven hydrogen production from water.	Water	265-270	nischarin	Homo sapiens	70-73
35168127-0	2022	Dimensional changes of CAD/CAM polymer crowns after water aging - An in vitro experiment.	Water	52-57	aconitate decarboxylase 1	Homo sapiens	23-30
35128674-4	2022	Here we show that Arabidopsis CPuORF19, CPuORF46 and CPuORF47, which are ancient in origin, regulate translation of any downstream ORF, in response to the agriculturally significant environmental signals, heat stress and water limitation.	Water	221-226	peptide upstream protein	Arabidopsis thaliana	53-61
35289618-1	2022	Microwave-assisted reactions in DMSO, between a hexa-lanthanide octahedral complex ((Ln6(mu6-O)(mu3-OH)8(NO3)6(H2O)12 2NO3 2H2O) with Ln = Nd-Yb plus Y) and either 3-halogenobenzoic acid (hereafter symbolized by 3-xbH with x = f or c for fluoro or chloro, respectively) or 4-halogenobenzoic acid (hereafter symbolized by 4-xbH with x = f, c, or b for fluoro, chloro, or bromo, respectively), lead to 1D lanthanide coordination polymers.	Water	111-114	hexosaminidase subunit alpha	Homo sapiens	48-52
35448259-8	2022	The deviated behavior of CL1-5 might be a consequence of the altered expression of aquaporins and the coupling of a cryoprotective agent and water, and has given a vision on possible studies over these properties, and their potential relationship to invasiveness and metastatic stability of the CL1 cell line.	Water	141-146	adhesion G protein-coupled receptor L1	Homo sapiens	25-30
35145418-1	2022	Aquaporin 5 (AQP5) is expressed in several cell types in the lung and regulates water transport, which contributes to barrier function during injury and the composition of glandular secretions.	Water	80-85	aquaporin 5	Homo sapiens	0-11
35145418-1	2022	Aquaporin 5 (AQP5) is expressed in several cell types in the lung and regulates water transport, which contributes to barrier function during injury and the composition of glandular secretions.	Water	80-85	aquaporin 5	Homo sapiens	13-17
35145418-11	2022	Niclosamide-treated A549 cell volume changes occurred more rapidly compared to control-treated cells, suggesting that increased Niclosamide-mediated increases in AQP5 expression affects functional water transport.	Water	197-202	aquaporin 5	Homo sapiens	162-166
35087991-10	2022	CO2 production from AntCor is much less than what was previously reported for Ant and Cor and exhibits two distinct regimes as a function of AntCor:H2O concentration.	Water	148-151	solute carrier family 25 member 6	Homo sapiens	78-81
35162987-3	2022	Similar effects were induced by MKT-077, a water-soluble rhodocyanine dye analog known to inhibit mortalin, but with notable toxicity in animals.	Water	43-48	heat shock protein 9	Mus musculus	98-106
35160669-4	2022	The mechanical performance and water damage resistance of BRA-rejuvenated RAP were studied.	Water	31-36	LDL receptor related protein associated protein 1	Homo sapiens	74-77
35207427-2	2022	It has been shown that the addition to water of either trimethylamine N-oxide (TMAO), glycine, or betaine causes a significant decrease of T(collapse) in the case of a specific ELP.	Water	39-44	nuclear receptor subfamily 5 group A member 1	Homo sapiens	177-180
34935834-1	2022	A solvothermal reaction of Cd(II) with the dicarboxyl-functionalized arylhydrazone pro-ligands, 5-(2-(2,4,6-trioxotetrahydro-pyrimidin-5(2H)-ylidene)hydrazineyl)isophthalic acid (H5L1) and 5-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)isophthalic acid (H3L2), or their halogen bond donor centre(s) decorated analogs 2,4,6-triiodo-5-(2-(2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)hydrazineyl)isophthalic acid (H5L3) and 5-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)-2,4,6-triiodoisophthalic acid (H3L4), leads to the formation of known (Cd(H3L1)(H2O)2)n (1) and new {(Cd(HL2)(H2O)2(DMF)) H2O}n (2), (Cd(H3L3))n (3) and {(Cd2(mu-H2O)2(mu-H2L4)2(H2L4)2) 2H2O}n (4) coordination compounds, respectively.	Water	545-548	CD2 molecule	Homo sapiens	620-623
34935834-1	2022	A solvothermal reaction of Cd(II) with the dicarboxyl-functionalized arylhydrazone pro-ligands, 5-(2-(2,4,6-trioxotetrahydro-pyrimidin-5(2H)-ylidene)hydrazineyl)isophthalic acid (H5L1) and 5-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)isophthalic acid (H3L2), or their halogen bond donor centre(s) decorated analogs 2,4,6-triiodo-5-(2-(2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)hydrazineyl)isophthalic acid (H5L3) and 5-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)-2,4,6-triiodoisophthalic acid (H3L4), leads to the formation of known (Cd(H3L1)(H2O)2)n (1) and new {(Cd(HL2)(H2O)2(DMF)) H2O}n (2), (Cd(H3L3))n (3) and {(Cd2(mu-H2O)2(mu-H2L4)2(H2L4)2) 2H2O}n (4) coordination compounds, respectively.	Water	575-578	CD2 molecule	Homo sapiens	620-623
34935834-1	2022	A solvothermal reaction of Cd(II) with the dicarboxyl-functionalized arylhydrazone pro-ligands, 5-(2-(2,4,6-trioxotetrahydro-pyrimidin-5(2H)-ylidene)hydrazineyl)isophthalic acid (H5L1) and 5-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)isophthalic acid (H3L2), or their halogen bond donor centre(s) decorated analogs 2,4,6-triiodo-5-(2-(2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)hydrazineyl)isophthalic acid (H5L3) and 5-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)-2,4,6-triiodoisophthalic acid (H3L4), leads to the formation of known (Cd(H3L1)(H2O)2)n (1) and new {(Cd(HL2)(H2O)2(DMF)) H2O}n (2), (Cd(H3L3))n (3) and {(Cd2(mu-H2O)2(mu-H2L4)2(H2L4)2) 2H2O}n (4) coordination compounds, respectively.	Water	587-590	CD2 molecule	Homo sapiens	620-623
34935834-1	2022	A solvothermal reaction of Cd(II) with the dicarboxyl-functionalized arylhydrazone pro-ligands, 5-(2-(2,4,6-trioxotetrahydro-pyrimidin-5(2H)-ylidene)hydrazineyl)isophthalic acid (H5L1) and 5-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)isophthalic acid (H3L2), or their halogen bond donor centre(s) decorated analogs 2,4,6-triiodo-5-(2-(2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)hydrazineyl)isophthalic acid (H5L3) and 5-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)-2,4,6-triiodoisophthalic acid (H3L4), leads to the formation of known (Cd(H3L1)(H2O)2)n (1) and new {(Cd(HL2)(H2O)2(DMF)) H2O}n (2), (Cd(H3L3))n (3) and {(Cd2(mu-H2O)2(mu-H2L4)2(H2L4)2) 2H2O}n (4) coordination compounds, respectively.	Water	627-630	CD2 molecule	Homo sapiens	620-623
35023666-4	2022	We recently demonstrated that apelin antagonises the hydro-osmotic effect of vasopressin on aquaporin-2 water channel (AQP-2) expression by reducing its mRNA and protein levels in collecting duct principal cells.	Water	104-109	aquaporin 2	Mus musculus	119-124
35023666-5	2022	The central role of these cells in water and sodium transport is governed by AQP-2 and the epithelial sodium channel (ENaC).	Water	35-40	aquaporin 2	Mus musculus	77-82
35023666-5	2022	The central role of these cells in water and sodium transport is governed by AQP-2 and the epithelial sodium channel (ENaC).	Water	35-40	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	118-122
35145743-0	2022	Crystal structure of a three-dimensional neodymium(III) coordination polymer, (Nd2(H2O)6(glutarato)(SO4)2) n. A three-dimensional coordination polymer, poly(hexa-aqua-(mu4-glutarato)bis(mu3-sulfato)-dineodymium(III)), (Nd2(glutarato)(SO4)2(H2O)6) n (glutarato2- = C5H6O4 2-), 1, consisting of cationic {Nd2(H2O)6(SO4)2} n 2n+ layers linked by bridging glutarate ligands, was synthesized by the microwave-heating technique within few minutes.	Water	240-243	adaptor related protein complex 4 subunit mu 1	Homo sapiens	168-171
35145743-0	2022	Crystal structure of a three-dimensional neodymium(III) coordination polymer, (Nd2(H2O)6(glutarato)(SO4)2) n. A three-dimensional coordination polymer, poly(hexa-aqua-(mu4-glutarato)bis(mu3-sulfato)-dineodymium(III)), (Nd2(glutarato)(SO4)2(H2O)6) n (glutarato2- = C5H6O4 2-), 1, consisting of cationic {Nd2(H2O)6(SO4)2} n 2n+ layers linked by bridging glutarate ligands, was synthesized by the microwave-heating technique within few minutes.	Water	307-310	adaptor related protein complex 4 subunit mu 1	Homo sapiens	168-171
35071308-8	2021	The results showed that after SBI, LRRK2 and phosphorylated Rab10 (p-Rab10) expression in neuronal cells were upregulated, and administration of PF-06447475 significantly reduced neuronal apoptosis, neuroinflammation, and brain water content 12 h after SBI and improved neurological deficit 72 h after SBI, which is related to the decreased expression of LRRK2 and p-Rab10, and the lessening of lysosomal overload stress.	Water	228-233	leucine-rich repeat kinase 2	Rattus norvegicus	35-40
34980737-0	2022	Gray-box Soft Sensor for Water Content Monitoring in Fluidized Bed Granulation.	Water	25-30	POC1 centriolar protein A	Homo sapiens	9-13
34467427-8	2022	In addition, reduction of intraglomerular pressure, improved energy supply chains and water regulation appear to be major mechanisms for renoprotection by SGLT-2 inhibitors.	Water	86-91	solute carrier family 5 member 2	Homo sapiens	155-161
35435747-4	2022	RESULTS: At 6 h, 12 h, 24 h, 3 days, and 7 days after mice with MCAO, CBX7 expression was gradually up-regulated and the peak level was reached at 24 h. Mice in the WT + MCAO group had increased infarct size, with significant increases in the modified neurological severity scores and water content in the brain, as well as the quantity of TUNEL-positive cells.	Water	285-290	chromobox 7	Mus musculus	70-74
35337623-1	2022	Vitamin B12 (cobalamin, Cbl, B12) is a water-soluble micronutrient synthesized exclusively by a group of microorganisms.	Water	39-44	Cbl proto-oncogene	Homo sapiens	24-32
35261247-0	2022	Effect of Oil-Displacing Agent Composition on Oil/Water Interface Stability of the Asphaltene-Rich ASP Flooding-Produced Water.	Water	50-55	assembly factor for spindle microtubules	Homo sapiens	99-102
35261247-0	2022	Effect of Oil-Displacing Agent Composition on Oil/Water Interface Stability of the Asphaltene-Rich ASP Flooding-Produced Water.	Water	121-126	assembly factor for spindle microtubules	Homo sapiens	99-102
21849984-4	2011	Our results revealed that water maze training significantly decreased laminin-beta1 (LB1) expression in the rat hippocampal CA1 area.	Water	26-31	laminin subunit beta 1	Rattus norvegicus	85-88
21849984-4	2011	Our results revealed that water maze training significantly decreased laminin-beta1 (LB1) expression in the rat hippocampal CA1 area.	Water	26-31	carbonic anhydrase 1	Rattus norvegicus	124-127
21981964-9	2011	MC3T3-E1 cells showed mineralization at day 28. mRNA expression levels of both osteopontin and runt-related transcription factor 2 in MC3T3-E1 cells were higher in the iQPR-H2O group compared with the control group.	Water	173-176	runt related transcription factor 2	Mus musculus	95-130
35261247-1	2022	In this work, the effect of oil-displacing agent composition on oil/water interface stability of the asphaltene-rich alkali-surfactant-polymer (ASP) flooding-produced water was systematically investigated, especially from the perspective of the interaction between oil displacement agents and asphaltene at the oil/water interface.	Water	68-73	assembly factor for spindle microtubules	Homo sapiens	144-147
35261247-1	2022	In this work, the effect of oil-displacing agent composition on oil/water interface stability of the asphaltene-rich alkali-surfactant-polymer (ASP) flooding-produced water was systematically investigated, especially from the perspective of the interaction between oil displacement agents and asphaltene at the oil/water interface.	Water	167-172	assembly factor for spindle microtubules	Homo sapiens	144-147
35261247-1	2022	In this work, the effect of oil-displacing agent composition on oil/water interface stability of the asphaltene-rich alkali-surfactant-polymer (ASP) flooding-produced water was systematically investigated, especially from the perspective of the interaction between oil displacement agents and asphaltene at the oil/water interface.	Water	315-320	assembly factor for spindle microtubules	Homo sapiens	144-147
35261247-6	2022	Finally, cream experiments were conducted to verify the effect of oil displacement agent composition on the oil/water separation efficiencies of asphaltene-rich ASP flooding-produced water.	Water	112-117	assembly factor for spindle microtubules	Homo sapiens	161-164
35261247-6	2022	Finally, cream experiments were conducted to verify the effect of oil displacement agent composition on the oil/water separation efficiencies of asphaltene-rich ASP flooding-produced water.	Water	183-188	assembly factor for spindle microtubules	Homo sapiens	161-164
21570752-11	2011	Colon production of IFNgamma is significantly reduced by GLN compared to H(2)O.	Water	73-78	interleukin 18	Rattus norvegicus	20-28
35391302-1	2022	nov., a new deep-water alpheid shrimp from the Mozambique Channel (Malacostraca: Decapoda: Caridea).	Water	17-22	cellular communication network factor 3	Homo sapiens	0-4
35391302-4	2022	nov., a very peculiar shrimp possibly associated with decomposing sea grass accumulations in deeper water.	Water	100-105	cellular communication network factor 3	Homo sapiens	0-3
35309430-2	2022	The solubility of MET HCl in water, water + N,N-dimethylformamide, water + acetonitrile, and water + n-propanol was measured by the gravimetric method under atmospheric pressure at temperatures ranging from 283.15 to 323.15 K. The solubility of MET HCl has a positive correlation with temperature and water content.	Water	29-34	SAFB like transcription modulator	Homo sapiens	18-21
21401652-2	2011	Aquaporin-3 (AQP3) facilitates water and glycerol transport across cell membranes and therefore regulates osmotic balance in different situations of stress.	Water	31-36	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
35115307-1	2022	BACKGROUND AND PURPOSE: ADC changes are useful in detecting ischemic brain injury, but mechanisms other than tissue pathology may affect the kinetic movement and diffusion of water molecules.	Water	175-180	antizyme inhibitor 2	Homo sapiens	24-27
21401652-2	2011	Aquaporin-3 (AQP3) facilitates water and glycerol transport across cell membranes and therefore regulates osmotic balance in different situations of stress.	Water	31-36	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
22256591-10	2011	Aquaporin-4, an water channel, was increased by ethanol 24 hr after traumatic brain injury in rat.	Water	16-21	aquaporin 4	Rattus norvegicus	0-11
35112148-6	2022	It should be underlined that MA-Tyr@MIP/GCE exhibited high sensitivity and excellent selectivity because MA-TyrMA-Tyr@MIP/GCE sensor has a higher imprinting factor (IF) toward BPS in respect to competitive analogs, i.e., bisphenol A, bisphenol B, and bisphenol F. The practical application of the sensor also showed good reproducibility and stability for the detection of BPS in human serum and water samples.	Water	395-400	aminomethyltransferase	Homo sapiens	122-125
35112148-7	2022	These results showed MA-Tyr@MIP/GCE successfully applied for the selective recognition of BPS in biological and water samples with high sensitivity and excellent selectivity.	Water	112-117	aminomethyltransferase	Homo sapiens	32-35
21830791-2	2011	Lowering of the conductivity of the whey from its initial value of about 5600 muS cm(-1) to about 2000-500 muS cm(-1) via diafiltration with water caused selective precipitation of MFGM when incubated for 30 min at pH 4.2 and 35  C. The whey proteins remained soluble in the supernatant under these conditions.	Water	141-146	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	181-185
35232958-0	2022	Pick up and dispose of pollutants from water via temperature-responsive micellar copolymers on magnetite nanorobots.	Water	39-44	protein interacting with PRKCA 1	Homo sapiens	0-4
21847469-2	2011	In comparison to the previously published HF/MM results, both B3LYP/MM and MP2/MM simulations clearly reveal stronger H(3)O(+)-water hydrogen bond interactions, which are reflected in a slightly greater compactness of the H(3)O(+) hydrate.	Water	127-132	tryptase pseudogene 1	Homo sapiens	75-78
35064631-0	2022	Oxygen Vacancy and Core-Shell Heterojunction Engineering of Anemone-Like CoP@CoOOH Bifunctional Electrocatalyst for Efficient Overall Water Splitting.	Water	134-139	caspase recruitment domain family member 16	Homo sapiens	73-76
21847469-3	2011	However, the B3LYP/MM simulation, although providing structural details very close to the MP2/MM data, shows an artificially slow dynamic nature of some first shell water molecules as a consequence of the formation of a long-lived H(3)O(+)   H(2)O hydrogen bonding structure.	Water	165-170	tryptase pseudogene 1	Homo sapiens	90-93
35091174-4	2022	Giant bar screens are settled over the river to collect riverine litter from the whole water column before water is released into the Sea.	Water	107-112	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	134-137
21793589-0	2011	Solvent-induced shift of the lowest singlet pi   pi* charge-transfer excited state of p-nitroaniline in water: an application of the TDDFT/EFP1 method.	Water	104-109	thioredoxin domain containing 11	Homo sapiens	139-143
35267786-2	2022	The present study reported the extraction of water-soluble elastin from broiler skin by using sodium chloride (NaCl), sodium hydroxide (NaOH), and oxalic acid treatment before freeze-drying.	Water	45-50	elastin	Bos taurus	59-66
21793589-2	2011	Molecular dynamics simulations of pNA with 150 EFP1 water molecules are used to model the condensed-phase and generate a simulated spectrum of the lowest singlet charge-transfer excitation.	Water	52-57	thioredoxin domain containing 11	Homo sapiens	47-51
35267786-7	2022	Therefore, water-soluble elastin powder extracted from broiler skin can be an alternative source of elastin as a biomaterial for tissue engineering applications.	Water	11-16	elastin	Bos taurus	25-32
21793589-3	2011	The TDDFT/EFP1 method successfully reproduces the experimental condensed-phase pi   pi* vertical excitation energy and solvent-induced red shift of pNA in water.	Water	155-160	thioredoxin domain containing 11	Homo sapiens	10-14
21812403-10	2011	The mechanism of release of sodiated PEG from an aqueous droplet was shown to be distinctly different from that of a protonated polyhistidine in a water nanodroplet, demonstrating sensitivity of the disintegration mechanism of the nanodroplet to the degree of hydrophilicity of the macroion.	Water	147-152	progestagen associated endometrial protein	Homo sapiens	37-40
35217956-2	2022	Nevertheless, the conservative form of the main percentage of 137Cs introduced in the marine environment (70%) makes 137Cs to be included in the salinity of sea water.	Water	161-166	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	157-160
21809941-7	2011	The horizontal dislocation of higher contaminated water masses and the vertical penetration of radioactive caesium resulted in a prolonged uniformity of the contamination level of the Baltic Sea.	Water	50-55	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	191-194
35167281-2	2022	Thermodynamically, similar to CaFx(H2O)142-x (x = 1 and 2), MgF(H2O)y+ (y = 14-20) contact ion pairs (CIPs) are more stable than their solvent-shared ion pairs (SSIPs), whereas the CIPs and SSIPs of MF2(H2O)y are almost isoenergetic.	Water	64-67	signal transducer and activator of transcription 5A	Homo sapiens	60-63
35167281-2	2022	Thermodynamically, similar to CaFx(H2O)142-x (x = 1 and 2), MgF(H2O)y+ (y = 14-20) contact ion pairs (CIPs) are more stable than their solvent-shared ion pairs (SSIPs), whereas the CIPs and SSIPs of MF2(H2O)y are almost isoenergetic.	Water	203-206	signal transducer and activator of transcription 5A	Homo sapiens	60-63
21721545-2	2011	Using the obtained GO/PDDA/AgNPs as SERS substrates, an ultrasensitive and label-free detection of folic acid in water and serum was demonstrated based on the inherent SERS spectra of folic acid.	Water	113-118	seryl-tRNA synthetase 1	Homo sapiens	36-40
21721545-2	2011	Using the obtained GO/PDDA/AgNPs as SERS substrates, an ultrasensitive and label-free detection of folic acid in water and serum was demonstrated based on the inherent SERS spectra of folic acid.	Water	113-118	seryl-tRNA synthetase 1	Homo sapiens	168-172
35424624-3	2022	The hydrolysis performances of Mg-based materials (Mg, MgH2, MgH2-BM and MgH2-RBM) with water are effectively improved under light-activation.	Water	88-93	RNA binding motif protein Y-linked family 2 member D, pseudogene	Homo sapiens	78-81
21721545-6	2011	The SERS spectra of the folic acid showed that the minimum detected concentration of folic acid in water was as low as 9 nM with a linear response range from 9 to 180 nM.	Water	99-104	seryl-tRNA synthetase 1	Homo sapiens	4-8
21849545-0	2011	Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study.	Water	31-36	solute carrier family 12, member 5	Mus musculus	124-128
35192167-2	2022	This research constructs a hybrid artificial intelligence model namely sequential minimal optimization-support vector machine (SMO-SVM) along with random forest (RF) as a benchmark model for predicting water quality values at the Wadi Saf-Saf river basin in Algeria.	Water	202-207	smoothened, frizzled class receptor	Homo sapiens	127-130
21709922-1	2011	A new predictive computational method for classifying clathrate hydrate promoter molecules is presented, based on the interaction energies between potential promoters and the water networks of sII and sH clathrates.	Water	175-180	transcription elongation factor A1	Homo sapiens	193-196
35252656-0	2022	An Unsteady-State Productivity Model and Main Influences on Low-Permeability Water-Bearing Gas Reservoirs at Ultrahigh Temperature/High Pressure.	Water	77-82	gastrin	Homo sapiens	91-94
21688815-0	2011	Bovine insulin-phosphatidylcholine mixed Langmuir monolayers: behavior at the air-water interface.	Water	82-87	insulin	Bos taurus	7-14
35252656-2	2022	For example, the Ledong block in the South China Sea is a typical gas reservoir characterized using ultrahigh temperature (190  C), high pressure (90 MPa), high water production, and low permeability (less than 1 mD).	Water	161-166	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	49-52
35252656-2	2022	For example, the Ledong block in the South China Sea is a typical gas reservoir characterized using ultrahigh temperature (190  C), high pressure (90 MPa), high water production, and low permeability (less than 1 mD).	Water	161-166	gastrin	Homo sapiens	66-69
35252656-4	2022	Accordingly, this study, which is based on the seepage theory, considers the influence of water production on the productivity of a single well; this study establishes an evaluation method for a low-permeability water-bearing gas reservoir vertical well (i.e., a highly deviated well) to determine how an unsteady state affects productivity.	Water	212-217	gastrin	Homo sapiens	226-229
35252656-9	2022	Research shows the following order of factor influence on productivity: produced water-gas volume ratio > permeability > stress sensitivity coefficient > reservoir thickness > start-up pressure gradient > well deviation angle > discharge radius.	Water	81-86	gastrin	Homo sapiens	87-90
35252656-10	2022	Water saturation is the main factor affecting the unsteady-state productivity of gas wells in low-permeability gas reservoirs.	Water	0-5	gastrin	Homo sapiens	81-84
35252656-10	2022	Water saturation is the main factor affecting the unsteady-state productivity of gas wells in low-permeability gas reservoirs.	Water	0-5	gastrin	Homo sapiens	111-114
35252656-12	2022	Moreover, a continuous increase in the stress sensitivity coefficient, start-up pressure gradient, and water saturation caused a leftward shift in the inflow performance relationship curves of the modeled gas wells, whereas their production decreased.	Water	103-108	gastrin	Homo sapiens	205-208
22007516-7	2011	Water extract of Schisandra chinensis (100-500 microg x mL(-1)) also exhibited inhibition on the activity of CYP450 isozymes in vitro, whereas multiple administrations (1.5 g x kg(-1), qd x 7d) had significant induction of CYP2E1 and inhibition on CYP2D2, no effect on CYP2C6, CYP3A1/2, CYP1A2 or CYP2C11.	Water	0-5	cytochrome P450, family 2, subfamily d, polypeptide 2	Rattus norvegicus	248-254
35133721-9	2022	NKCC1 is a co-transporter involved in cell volume increases either independently through cotransport of water or a functional interaction with AQPs.	Water	104-109	solute carrier family 12 member 2	Homo sapiens	0-5
22007516-7	2011	Water extract of Schisandra chinensis (100-500 microg x mL(-1)) also exhibited inhibition on the activity of CYP450 isozymes in vitro, whereas multiple administrations (1.5 g x kg(-1), qd x 7d) had significant induction of CYP2E1 and inhibition on CYP2D2, no effect on CYP2C6, CYP3A1/2, CYP1A2 or CYP2C11.	Water	0-5	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	297-304
21702491-4	2011	This fluorescence difference may be attributed to the intermolecular photoinduced proton transfer (PPT) process involving the protic solvent water molecules.	Water	141-146	palmitoyl-protein thioesterase 1	Homo sapiens	99-102
35048936-6	2022	The N-Fe-Ni3S2@NiP2/NF electrode couple also has relatively long-term durability in alkaline solutions, maintaining a stable current density for 15 h at 1.35 V. The density functional theory (DFT) calculation shows that the in situ generated Fe doped nanooxides exhibit strong water adsorption energy, which may be one of the reasons for the good catalytic activity.	Water	277-282	BCL2 interacting protein 2	Homo sapiens	15-19
35140543-1	2022	With the solvothermal reactions of flexible tetracarboxylic acid ligand with the Cd(II) and Ca(II) ions, we acquired a new heterometallic coordination polymer formulated as {(Cd2Ca2(L)2(DMF)2(H2O)7) (DMF) 2(H2O)}n (1, H4L is 5-(bis(4-carboxybenzyl)amino)isophthalic acid, DMF is N,N"-Dimethylformamide).	Water	192-195	H4 clustered histone 7	Homo sapiens	218-221
35140543-1	2022	With the solvothermal reactions of flexible tetracarboxylic acid ligand with the Cd(II) and Ca(II) ions, we acquired a new heterometallic coordination polymer formulated as {(Cd2Ca2(L)2(DMF)2(H2O)7) (DMF) 2(H2O)}n (1, H4L is 5-(bis(4-carboxybenzyl)amino)isophthalic acid, DMF is N,N"-Dimethylformamide).	Water	207-210	H4 clustered histone 7	Homo sapiens	218-221
21702491-5	2011	Similarly, this intermolecular PPT process was also observed in the high-water-content CH(3)CN aqueous solution (e.g., CH(3)CN/H(2)O = 5/95, v/v).	Water	73-78	palmitoyl-protein thioesterase 1	Homo sapiens	31-34
21702491-8	2011	In high-water-content (CH(3)CN/H(2)O = 5/95, v/v) aqueous solution compound 2 shows a selective "turn-on" response toward Zn(2+), with a 10-fold enhancement in the fluorescence intensity at 428 nm and a 62 nm blue shift of the emission maximum (490 to 428 nm) due to the inhibition of intermolecular PPT process upon chelating with Zn(2+).	Water	8-13	palmitoyl-protein thioesterase 1	Homo sapiens	300-303
21666916-2	2011	Molecular dynamics simulations demonstrate that the forces acting on a model microscope tip result from the direct interaction between a tip and a surface, and forces entirely due to the water structure around both tip and surface.	Water	187-192	TOR signaling pathway regulator	Homo sapiens	88-91
35163454-6	2022	It has been shown that water-soluble products formed during A2E photooxidation and containing carbonyl compounds cause modification of serum albumin and hemoglobin, measured by an increase in fluorescence intensity at 440-455 nm.	Water	23-28	albumin	Bos taurus	141-148
21666916-2	2011	Molecular dynamics simulations demonstrate that the forces acting on a model microscope tip result from the direct interaction between a tip and a surface, and forces entirely due to the water structure around both tip and surface.	Water	187-192	TOR signaling pathway regulator	Homo sapiens	137-140
21666916-2	2011	Molecular dynamics simulations demonstrate that the forces acting on a model microscope tip result from the direct interaction between a tip and a surface, and forces entirely due to the water structure around both tip and surface.	Water	187-192	TOR signaling pathway regulator	Homo sapiens	137-140
21666916-3	2011	The observed force is a balance between largely repulsive potential energy changes as the tip approaches and the entropic gain when water is sterically prevented from occupying sites near the tip and surface.	Water	132-137	TOR signaling pathway regulator	Homo sapiens	192-195
21666916-5	2011	An investigation into the dynamics of water confined between tip and surface shows that water diffusion can be slowed by at least two orders of magnitude compared to its rate in bulk solution.	Water	38-43	TOR signaling pathway regulator	Homo sapiens	61-64
35126177-1	2021	Arginine vasopressin (AVP) stimulates the concentration of renal urine by increasing the principal cell expression of aquaporin-2 (AQP2) water channels.	Water	137-142	aquaporin 2	Mus musculus	118-129
21666916-5	2011	An investigation into the dynamics of water confined between tip and surface shows that water diffusion can be slowed by at least two orders of magnitude compared to its rate in bulk solution.	Water	88-93	TOR signaling pathway regulator	Homo sapiens	61-64
35126177-1	2021	Arginine vasopressin (AVP) stimulates the concentration of renal urine by increasing the principal cell expression of aquaporin-2 (AQP2) water channels.	Water	137-142	aquaporin 2	Mus musculus	131-135
21563838-1	2011	A new series of degradable and water-swellable cross-linked PEG phosphoester polymers (CPPs) based on a facile cross-linked reaction between diphosphoesters of polyethylene glycol (P-PEG-P) and diglycidyl ether of polyethylene glycol (E-PEG-E) has been prepared and characterized.	Water	31-36	progestagen associated endometrial protein	Homo sapiens	60-63
35013202-3	2022	Herein, we present an approach to fabricate a high surface distribution density of iridium (Ir) SAC on nickel-iron sulfide nanosheet arrays substrate (Ir1/NFS), which delivers a high water oxidation activity.	Water	183-188	nischarin	Homo sapiens	151-154
21563838-1	2011	A new series of degradable and water-swellable cross-linked PEG phosphoester polymers (CPPs) based on a facile cross-linked reaction between diphosphoesters of polyethylene glycol (P-PEG-P) and diglycidyl ether of polyethylene glycol (E-PEG-E) has been prepared and characterized.	Water	31-36	progestagen associated endometrial protein	Homo sapiens	183-186
35013213-0	2022	Sea-ice retreat suggests re-organization of water mass transformation in the Nordic and Barents Seas.	Water	44-49	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
21421215-1	2011	A novel sensitive and recyclable SERS substrate which can actively concentrate chromate (Cr(VI)) in water and substantially enhance Raman signal was synthesized as uniform Fe(3)O(4)@Ag nanoparticles.	Water	100-105	seryl-tRNA synthetase 1	Homo sapiens	33-37
35013213-1	2022	Water mass transformation in the Nordic and Barents Seas, triggered by air-sea heat fluxes, is an integral component of the Atlantic Meridional Overturning Circulation (AMOC).	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	75-78
35013213-3	2022	Here we present an analysis covering 1950-2020 of the spatiotemporal variability of the air-sea heat fluxes along the region"s boundary currents, where water mass transformation impacts are large.	Water	152-157	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	92-95
35013213-4	2022	We find there is an increase in the air-sea heat fluxes along these currents that is a function of the currents" orientation relative to the axis of sea-ice change suggesting enhanced water mass transformation is occurring.	Water	184-189	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	40-43
35013213-4	2022	We find there is an increase in the air-sea heat fluxes along these currents that is a function of the currents" orientation relative to the axis of sea-ice change suggesting enhanced water mass transformation is occurring.	Water	184-189	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	149-152
21421215-6	2011	SERS spectra of Cr(VI) in simulated and real contaminated water showed that the symmetric stretching vibrations of Cr-O occurred at 796 cm(-1).	Water	58-63	seryl-tRNA synthetase 1	Homo sapiens	0-4
21382684-2	2011	In this investigation, the MEEKC technique was applied for estimation of n-octanol-water partition coefficient (logP(oct)) of a series of antiproliferative complexes of gallium(III) and iron(III) with (4)N-substituted alpha-N-heterocyclic thiosemicarbazones.	Water	83-88	plexin A2	Homo sapiens	75-78
34997868-7	2022	As a case study, the framework was implemented in Changyang County, China, an NKEFA for water and soil retention in the Three Gorges Reservoir Region.	Water	88-93	peroxiredoxin 1	Homo sapiens	78-83
21472183-1	2011	Asymmetric Michael reactions of thiols with enones were catalyzed by a Sc(OTf)(3)-chiral bipyridine complex at room temperature in water without using any organic solvents, to afford the desired sulfides in high yields with high enantioselectivities.	Water	131-136	POU class 5 homeobox 1	Homo sapiens	71-80
35054478-0	2022	Deep Sea Water-Dissolved Organic Matter Intake Improves Hyperlipidemia and Inhibits Thrombus Formation and Vascular Inflammation in High-Fat Diet Hamsters.	Water	9-14	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	5-8
35054478-2	2022	Deep sea water (DSW) is characterized by its clearance and abundant nutrients with antioxidant and anti-inflammatory activity to confer therapeutic potential.	Water	9-14	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	5-8
34980804-9	2022	Cpd1 has great advantages of higher water solubility and shorter plasma half-life compared to dantrolene.	Water	36-41	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	Mus musculus	0-4
35465284-3	2022	The sodium-potassium-chloride co-transporter isoform 1 (NKCC1), localized at the basolateral surface of the lung epithelium, drives water transport via back transport of Na+ and Cl- to the alveolar air space.	Water	132-137	solute carrier family 12 member 2	Homo sapiens	56-61
21502813-1	2011	Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins that allow the movement of water and other small solutes, especially glycerol, through cell membranes.	Water	110-115	aquaporin 3 (Gill blood group)	Homo sapiens	19-23
21420942-3	2011	The purpose of the present study was to examine the pharmacological profiles of MP-124, a novel water-soluble PARP-1 inhibitor, and its neuroprotective effects on ischemic injury in vitro and in vivo.	Water	96-101	poly (ADP-ribose) polymerase 1	Rattus norvegicus	110-116
21454538-2	2011	LTC(4) synthase is the nuclear membrane-embedded enzyme responsible for LTC(4) biosynthesis, catalyzing the conjugation of two substrates that have considerably different water solubility; that amphipathic LTA(4) as a derivative of arachidonic acid and a water-soluble glutathione (GSH).	Water	171-176	leukotriene C4 synthase	Homo sapiens	0-15
21454538-2	2011	LTC(4) synthase is the nuclear membrane-embedded enzyme responsible for LTC(4) biosynthesis, catalyzing the conjugation of two substrates that have considerably different water solubility; that amphipathic LTA(4) as a derivative of arachidonic acid and a water-soluble glutathione (GSH).	Water	255-260	leukotriene C4 synthase	Homo sapiens	0-15
21516532-6	2011	Here, we show using explicit water molecular dynamics and well-tempered metadynamics that for the coil2 domain of vimentin IFs the stutter is more stable in a non-alpha-helical, unfolded state.	Water	29-34	vimentin	Homo sapiens	114-122
21321052-2	2011	Leaves of C(4) crops have increased nitrogen and water use efficiencies compared with C(3) species.	Water	49-54	complement C4A (Rodgers blood group)	Homo sapiens	10-14
20623308-7	2011	Comparison of DFT and MP2 energies of all 57 structures stable in water indicates that, in practice, one zwitterionic and one neutral conformer determine the equilibrium in water.	Water	66-71	tryptase pseudogene 1	Homo sapiens	22-25
20623308-7	2011	Comparison of DFT and MP2 energies of all 57 structures stable in water indicates that, in practice, one zwitterionic and one neutral conformer determine the equilibrium in water.	Water	173-178	tryptase pseudogene 1	Homo sapiens	22-25
21228390-3	2011	In contrast to ultrasound biomicroscopy, AS-OCT eliminates the need for a water bath in contact with the globe.	Water	74-79	plexin A2	Homo sapiens	44-47
21116615-6	2011	Application of FIA-PIF for the analysis of fortified natural water samples collected from Senegal yielded good recovery values (84-112%).	Water	61-66	PIF1 5'-to-3' DNA helicase	Homo sapiens	19-22
21367603-3	2011	Herein, we report the synthesis and molecular interactions of two water soluble, fluorescent polymers which demonstrate selective interactions with MMP-9 compared to MMP-7 and -10.	Water	66-71	matrix metallopeptidase 7	Homo sapiens	166-179
21191421-1	2011	Aquaporin-3 (AQP3) is a water/glycerol-transporting protein expressed in keratinocytes of the epidermis.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
21191421-1	2011	Aquaporin-3 (AQP3) is a water/glycerol-transporting protein expressed in keratinocytes of the epidermis.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
21191421-2	2011	We previously showed that AQP3-mediated transport of water and glycerol is involved in keratinocyte migration and proliferation, respectively.	Water	53-58	aquaporin 3 (Gill blood group)	Homo sapiens	26-30
21456637-0	2011	Communication: Single crystal x-ray diffraction observation of hydrogen bonding between 1-propanol and water in a structure II clathrate hydrate.	Water	103-108	transcription elongation factor A1	Homo sapiens	114-126
21456637-2	2011	X-ray structural analysis shows that the 1-propanol oxygen atom is at a distance of 2.749 and 2.788 A from the closest clathrate hydrate water oxygen atoms from a hexagonal face of the large sII cage.	Water	137-142	transcription elongation factor A1	Homo sapiens	191-194
21456637-8	2011	The individual cage distortions resulting from guest-host hydrogen bonding from the simulations are rather large, but due to the random nature of the hydrogen bonding of the guest with the 24 water molecules making up the hexagonal faces of the large sII cages, these distortions are not observed in the x-ray structure.	Water	192-197	transcription elongation factor A1	Homo sapiens	251-254
21332170-0	2011	Dipeptidyl peptidase IV dependent water-soluble prodrugs of highly lipophilic bicyclic nucleoside analogues.	Water	34-39	dipeptidylpeptidase 4	Mus musculus	0-23
21436885-5	2011	In this study, we showed that Y. pestis became nonculturable by normal laboratory methods after 21 days in a low-temperature tap water microcosm.	Water	129-134	repA translation protein	Yersinia pestis	125-128
21436885-9	2011	This study provides compelling evidence that Y. pestis persists in a low-temperature tap water microcosm in a viable state yet is unable to be cultured under normal laboratory conditions, which may prove useful in risk assessment and remediation efforts, particularly in the event of an intentional release of this organism.	Water	89-94	repA translation protein	Yersinia pestis	85-88
21130866-8	2011	FasL up-regulation; activation of caspases-8, -2, -9, and -3; and chromatin condensation were decreased by the p53 inhibitor pifithrin-alpha, implicating p53 as an upstream factor in the activation of death receptor-mediated apoptosis by H(2)O(2).	Water	238-243	Fas ligand	Homo sapiens	0-4
21408176-2	2011	This specific distribution of AQP4 plays a major role in maintaining water homeostasis in the brain.	Water	69-74	aquaporin 4	Rattus norvegicus	30-34
21209006-2	2011	When in need for water conservation, vasopressin, released from the brain, binds renal principal cells and initiates a signaling cascade resulting in the insertion of aquaporin-2 (AQP2) water channels in the apical membrane and water reabsorption.	Water	186-191	aquaporin 2	Mus musculus	167-178
21209006-2	2011	When in need for water conservation, vasopressin, released from the brain, binds renal principal cells and initiates a signaling cascade resulting in the insertion of aquaporin-2 (AQP2) water channels in the apical membrane and water reabsorption.	Water	186-191	aquaporin 2	Mus musculus	180-184
21209006-2	2011	When in need for water conservation, vasopressin, released from the brain, binds renal principal cells and initiates a signaling cascade resulting in the insertion of aquaporin-2 (AQP2) water channels in the apical membrane and water reabsorption.	Water	186-191	aquaporin 2	Mus musculus	167-178
21209006-2	2011	When in need for water conservation, vasopressin, released from the brain, binds renal principal cells and initiates a signaling cascade resulting in the insertion of aquaporin-2 (AQP2) water channels in the apical membrane and water reabsorption.	Water	186-191	aquaporin 2	Mus musculus	180-184
21209006-10	2011	Together, our results indicate that ATP and dopamine counteract AVP-induced water permeability by increasing AQP2 degradation in lysosomes, preceded by ubiquitin-dependent internalization, and by decreasing AQP2 gene transcription by reducing the AVP-induced cAMP levels.	Water	76-81	aquaporin 2	Mus musculus	109-113
21209006-10	2011	Together, our results indicate that ATP and dopamine counteract AVP-induced water permeability by increasing AQP2 degradation in lysosomes, preceded by ubiquitin-dependent internalization, and by decreasing AQP2 gene transcription by reducing the AVP-induced cAMP levels.	Water	76-81	aquaporin 2	Mus musculus	207-211
21675200-2	2011	This review summarizes recent advances related to molecular events underlying the short-term control of water permeability which occurs via vesicular trafficking of AQP2 to the cell apical membrane, and long-term control through changes in the gene expression and the abundance of AQP-2, -3 and -4.	Water	104-109	aquaporin 2	Homo sapiens	165-169
21675200-2	2011	This review summarizes recent advances related to molecular events underlying the short-term control of water permeability which occurs via vesicular trafficking of AQP2 to the cell apical membrane, and long-term control through changes in the gene expression and the abundance of AQP-2, -3 and -4.	Water	104-109	aquaporin 2	Homo sapiens	281-297
21247114-9	2011	Elevated stability and water exchange rate indicate that the presence of cyclobutyl on the carbon backbone imparts rigidity and steric constraint to [Gd(CB-TTDA)(H(2)O)](2-)and [Gd(Bz-CB-TTDA)(H(2)O)](2-).	Water	23-28	general transcription factor IIH subunit 5	Homo sapiens	156-160
21162519-0	2011	Melt processing of hexa-peri-hexabenzocoronene on the water surface.	Water	54-59	hexosaminidase subunit alpha	Homo sapiens	19-23
21162519-1	2011	A discotic polycyclic aromatic hydrocarbon, hexa-peri-hexabenzocoronene, was oriented by slow cooling from the isotropic phase on a water surface as a film.	Water	132-137	hexosaminidase subunit alpha	Homo sapiens	44-48
21194206-1	2011	For modeling the sorption of organic compounds in soils it is typically assumed that the organic carbon/water partitioning coefficient (Koc) of neutral organic chemicals can be treated as a constant property that remains unaffected by the type of soil organic matter as well as pH in the soil solution.	Water	104-109	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	136-139
20813209-3	2011	The HPG-g-CD molecules could self-assemble into multimolecular spherical micelles in water, the size of which ranged from 200 to 300 nm, with good dispersity.	Water	85-90	glutaryl-CoA dehydrogenase	Homo sapiens	8-12
20926801-7	2011	ESR1 regulates ion transport and water reabsorption in the efferent ducts and epididymis, and its regulation of other associated genes is continually being uncovered.	Water	33-38	estrogen receptor 1 (alpha)	Mus musculus	0-4
21109284-4	2011	Differences in macroalgal growth were shown when submitted to prophylactic and therapeutic concentrations of furaltadone in the water (16 and 32 mug mL-1, respectively).	Water	128-133	L1 cell adhesion molecule	Mus musculus	149-153
20614195-1	2011	BACKGROUND, AIM AND SCOPE: This paper presents a preliminary study of the water profile with reference to microbiological parameters, required by Directive 2006/07/EC (European Community 2006) concerning the management of bathing water quality, in the coastal belt of the Province of Venice (Italy, Northern Adriatic Sea).	Water	74-79	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	317-320
21118692-9	2011	As the receptor for GPA2/GPB5 stimulates the production of cyclic AMP (cAMP) and is highly expressed in the hindgut, where cAMP stimulates water reabsorption in locusts, it is suggested that GPA2/GPB5 may be an insect anti-diuretic hormone.	Water	139-144	Glycoprotein hormone alpha 2	Drosophila melanogaster	20-24
21118692-9	2011	As the receptor for GPA2/GPB5 stimulates the production of cyclic AMP (cAMP) and is highly expressed in the hindgut, where cAMP stimulates water reabsorption in locusts, it is suggested that GPA2/GPB5 may be an insect anti-diuretic hormone.	Water	139-144	Glycoprotein hormone alpha 2	Drosophila melanogaster	191-195
20881307-11	2011	IL-17A and IL-17F were significantly higher in the eyes of EAU-induced mice at day 7.	Water	59-62	interleukin 17F	Mus musculus	11-17
21408051-0	2011	ESKIMO1 disruption in Arabidopsis alters vascular tissue and impairs water transport.	Water	69-74	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	0-7
21408051-2	2011	In the model species Arabidopsis thaliana, the ESKIMO1 (ESK1) gene has been described as involved in freezing, cold and salt tolerance as well as in water economy: esk1 mutants have very low evapo-transpiration rates and high water-use efficiency.	Water	149-154	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	47-54
21408051-2	2011	In the model species Arabidopsis thaliana, the ESKIMO1 (ESK1) gene has been described as involved in freezing, cold and salt tolerance as well as in water economy: esk1 mutants have very low evapo-transpiration rates and high water-use efficiency.	Water	149-154	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	56-60
21408051-2	2011	In the model species Arabidopsis thaliana, the ESKIMO1 (ESK1) gene has been described as involved in freezing, cold and salt tolerance as well as in water economy: esk1 mutants have very low evapo-transpiration rates and high water-use efficiency.	Water	149-154	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	164-168
21408051-2	2011	In the model species Arabidopsis thaliana, the ESKIMO1 (ESK1) gene has been described as involved in freezing, cold and salt tolerance as well as in water economy: esk1 mutants have very low evapo-transpiration rates and high water-use efficiency.	Water	226-231	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	47-54
21408051-2	2011	In the model species Arabidopsis thaliana, the ESKIMO1 (ESK1) gene has been described as involved in freezing, cold and salt tolerance as well as in water economy: esk1 mutants have very low evapo-transpiration rates and high water-use efficiency.	Water	226-231	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	56-60
21408051-2	2011	In the model species Arabidopsis thaliana, the ESKIMO1 (ESK1) gene has been described as involved in freezing, cold and salt tolerance as well as in water economy: esk1 mutants have very low evapo-transpiration rates and high water-use efficiency.	Water	226-231	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	164-168
21211014-7	2011	Twelve of 15 MRSA isolates collected from the water had identical genetic characteristics as the organisms isolated from the participants exposed to that water while the remaining 3 MRSA were without matching nasal isolates from participants.	Water	46-51	solute carrier family 9 member A6	Homo sapiens	13-17
21211014-7	2011	Twelve of 15 MRSA isolates collected from the water had identical genetic characteristics as the organisms isolated from the participants exposed to that water while the remaining 3 MRSA were without matching nasal isolates from participants.	Water	154-159	solute carrier family 9 member A6	Homo sapiens	13-17
21143292-3	2011	We investigated whether disturbances in water homeostasis in infants with patent ductus arteriosus (PDA) treated with prostaglandin inhibitors can be attributed to activation of AQP2.	Water	40-45	aquaporin 2	Homo sapiens	178-182
20920466-6	2011	Using Langmuir monolayers and molecular simulations of the corresponding system, we study several thermodynamic and kinetic aspects of the insertion of Abeta peptide into DPPG monolayers in water and trehalose subphases.	Water	190-195	amyloid beta (A4) precursor protein	Mus musculus	152-157
20920466-7	2011	In the water subphase, the insertion of the Abeta peptide into the monolayer exhibits a lag time which decreases with increasing temperature of the subphase.	Water	7-12	amyloid beta (A4) precursor protein	Mus musculus	44-49
21415534-1	2011	Aquaporin (AQP) 3 plays an important role in regulating faecal water content in the colon.	Water	63-68	aquaporin 3 (Gill blood group)	Rattus norvegicus	0-17
21719997-7	2011	The inhibitory effect of BAPTA/AM or 2-APB on the H(2)O(2)-induced apoptosis was largely attenuated when the drug was added 30 min or 1 h after start of the treatment with H(2)O(2).	Water	50-55	arginyl aminopeptidase	Rattus norvegicus	39-42
20817024-2	2011	However, according to recent investigations, it appears that interstitial fluid (ISF) and CSF are formed by water filtration across the walls of arterial capillaries in the central nervous system (CNS), while plasma osmolytes are sieved (retained) so that capillary osmotic counterpressure is generated, which is instrumental in ISF/CSF water absorption into venous capillaries and postcapillary venules.	Water	108-113	colony stimulating factor 2	Homo sapiens	90-93
20817024-2	2011	However, according to recent investigations, it appears that interstitial fluid (ISF) and CSF are formed by water filtration across the walls of arterial capillaries in the central nervous system (CNS), while plasma osmolytes are sieved (retained) so that capillary osmotic counterpressure is generated, which is instrumental in ISF/CSF water absorption into venous capillaries and postcapillary venules.	Water	337-342	colony stimulating factor 2	Homo sapiens	90-93
20817024-3	2011	This hypothesis is supported by experiments showing that water, which constitutes 99% of CSF and ISF bulk, does not flow along CSF spaces since it is rapidly absorbed into adjacent CNS microvessels, while distribution of other substances along CSF spaces depends on the rate of their removal into microvessels: faster removal means more limited distribution.	Water	57-62	colony stimulating factor 2	Homo sapiens	89-100
20817024-3	2011	This hypothesis is supported by experiments showing that water, which constitutes 99% of CSF and ISF bulk, does not flow along CSF spaces since it is rapidly absorbed into adjacent CNS microvessels, while distribution of other substances along CSF spaces depends on the rate of their removal into microvessels: faster removal means more limited distribution.	Water	57-62	colony stimulating factor 2	Homo sapiens	89-92
26069571-2	2011	T2-mapping at 3 T has been optimized for the ankle and can be used to noninvasively evaluate cartilage collagen and water content.	Water	116-121	brachyury 2	Rattus norvegicus	0-2
21691091-1	2011	Aquaporin-2 (AQP2) increases the water permeability of renal collecting ducts in response to vasopressin.	Water	33-38	aquaporin 2	Homo sapiens	0-11
21691091-1	2011	Aquaporin-2 (AQP2) increases the water permeability of renal collecting ducts in response to vasopressin.	Water	33-38	aquaporin 2	Homo sapiens	13-17
21720510-12	2011	CONCLUSION: These results suggested that digestion of the microemulsion by pancreatic lipase plays an important role in enhancing oral bioavailability of water-soluble drugs.	Water	154-159	pancreatic lipase	Rattus norvegicus	75-92
21790050-3	2011	The effects of pH, chelating agent dosage, and other heavy metal ions on the performance of PBD in Cd2+ removal from water are investigated.	Water	117-122	CD2 molecule	Homo sapiens	99-102
20933102-2	2011	Lon is upregulated in the presence of substances such as stavudine (d4T), D-deoxyribose (dRib), that increase the intracellular reactive oxygen species (ROS) levels, or in the presence of H(2)O(2.)	Water	188-193	lon peptidase 1, mitochondrial	Homo sapiens	0-3
22053184-8	2011	Thus, over-expression of endothelial ET-1 in TET-1 mice may contribute to increased glutamate-induced neurotoxicity on neuronal cells and water accumulation in inner retina leading to edema.	Water	138-143	endothelin 1	Mus musculus	37-41
21912606-8	2011	These phenotypes correlated with increased water retention and higher gas exchange parameters in transgenic plants that overexpress AtUCP1.	Water	43-48	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	132-138
21090740-6	2010	All calculations of the solute-water complexes were carried out at an MP2 level of theory and supplemented with correction for higher order correlation terms at CCSD(T) level, using the 6-31+G(d,p) basis set.	Water	31-36	tryptase pseudogene 1	Homo sapiens	70-73
21090592-4	2010	The ligands dpk OH(-) and dpk CH(3)O(-) result from solvolysis and ulterior deprotonation of dpk in water and methanol, respectively.	Water	100-105	TAO kinase 3	Homo sapiens	12-15
21090592-4	2010	The ligands dpk OH(-) and dpk CH(3)O(-) result from solvolysis and ulterior deprotonation of dpk in water and methanol, respectively.	Water	100-105	TAO kinase 3	Homo sapiens	26-29
21090592-4	2010	The ligands dpk OH(-) and dpk CH(3)O(-) result from solvolysis and ulterior deprotonation of dpk in water and methanol, respectively.	Water	100-105	TAO kinase 3	Homo sapiens	26-29
21090753-0	2010	Resistance of beta-casein at the air-water interface to enzymatic cleavage.	Water	37-42	casein beta	Homo sapiens	14-25
21187974-0	2010	Inhibition of dehydration-induced water intake by glucocorticoids is associated with activation of hypothalamic natriuretic peptide receptor-A in rat.	Water	34-39	natriuretic peptide receptor 1	Rattus norvegicus	112-142
21164942-2	2010	Using a mid-IR generalized polarization gating modulated by a weaker mid-IR linearly polarized chirped field, the ionization, acceleration and recombination steps in the HHG process are simultaneously controlled, leading to the efficient generation of an ultra-broadband supercontinuum covered by the spectral range from ultraviolet to water window x-ray.	Water	336-341	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	170-173
20971924-5	2010	Mice lacking IL-13Ralpha2 had significantly increased transepidermal water loss, cutaneous inflammation, peripheral eosinophilia, and IgG1 and IgE levels compared with wild-type mice.	Water	69-74	interleukin 13 receptor, alpha 2	Mus musculus	13-25
20940188-1	2010	PURPOSE: IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90).	Water	29-34	heat shock protein 90 alpha family class A member 1	Homo sapiens	64-85
20940188-1	2010	PURPOSE: IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90).	Water	29-34	heat shock protein 90 alpha family class A member 1	Homo sapiens	87-92
20856955-1	2010	MP2/6-311++G(d,p) calculations have been carried out to investigate the conformation, protonation and the hydrogen bonding interactions with water of several halogenated ethers (CH(3)OCH(2)Cl, CH(2)ClOCH(2)Cl, CH(3)OCHCl(2), CHFClOCHF(2)).	Water	141-146	tryptase pseudogene 1	Homo sapiens	0-3
20882969-1	2010	Mix in water and then stir.	Water	7-12	Mix paired-like homeobox	Homo sapiens	0-3
21231184-1	2010	Based on density functional calculations we predict water ice to attain two new crystal structures with Pbca and Cmcm symmetry at 7.6 and 15.5 Mbar, respectively.	Water	52-57	PBCA	Homo sapiens	104-108
21231185-2	2010	Molecular dynamics simulations demonstrate that the forces acting on a microscope tip result from the direct interaction between a tip and a surface, and forces entirely due to the water structure around both tip and surface.	Water	181-186	TOR signaling pathway regulator	Homo sapiens	82-85
21231185-2	2010	Molecular dynamics simulations demonstrate that the forces acting on a microscope tip result from the direct interaction between a tip and a surface, and forces entirely due to the water structure around both tip and surface.	Water	181-186	TOR signaling pathway regulator	Homo sapiens	131-134
21231185-2	2010	Molecular dynamics simulations demonstrate that the forces acting on a microscope tip result from the direct interaction between a tip and a surface, and forces entirely due to the water structure around both tip and surface.	Water	181-186	TOR signaling pathway regulator	Homo sapiens	131-134
21231185-3	2010	The observed force depends on a tip structure and is a balance between largely repulsive potential energy changes as the tip approaches and the entropic gain when water is sterically prevented from occupying sites near the tip and surface.	Water	163-168	TOR signaling pathway regulator	Homo sapiens	32-35
20620225-1	2010	Prolactin plays an essential role in ion uptake as well as reduction in ion and water permeability of osmoregulatory surfaces in euryhaline fish.	Water	80-85	prolactin	Kryptolebias marmoratus	0-9
19911291-4	2010	The potential consequences, in terms of water pollution from nitrates of a BMP expressly applied to reduce P pollution are also discussed.	Water	40-45	bone morphogenetic protein 1	Homo sapiens	75-78
19936955-0	2010	Assessing BMP effectiveness: multiprocedure analysis of observed water quality data.	Water	65-70	bone morphogenetic protein 1	Homo sapiens	10-13
20659787-5	2010	The water holding capacity test of filter-paper fluid uptake was moderately correlated with panel scores of softness (r=0.33), initial tenderness (r=0.38), chewiness (r=0.40), juiciness (r=-0.27), flavor intensity (r=-0.23), and off-flavor (r=0.30).	Water	4-9	OFFFLAV	Sus scrofa	229-239
20545884-5	2010	ProDH downregulation by low water potential and upregulation by stress release was not impaired in aba2-1, p5cs1 or p5cs1/aba2-1 compared with wild type despite differing ABA and proline levels in these mutants.	Water	28-33	proline dehydrogenase 1	Homo sapiens	0-5
21273684-1	2010	The Kir4.1 channel is an inward rectifying potassium channel involved in the control of potassium and water movement in mammalian cells.	Water	102-107	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	4-10
20869751-0	2010	Temporal variation of 240Pu/239Pu atom ratio and 239+240Pu inventory in water columns of the Japan Sea.	Water	72-77	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	99-102
20929239-3	2010	Here, we show that the long distance tip-wear endurance issue can be resolved by introducing a thin water layer at the tip-media interface-thin enough to form a liquid crystal.	Water	100-105	TOR signaling pathway regulator	Homo sapiens	37-40
2683906-5	1989	Also, the frequency of swallows decreased greatly at nasal CPAP of 15 cm H2O during continuous infusion of water.	Water	73-76	centromere protein J	Homo sapiens	59-63
2683906-5	1989	Also, the frequency of swallows decreased greatly at nasal CPAP of 15 cm H2O during continuous infusion of water.	Water	107-112	centromere protein J	Homo sapiens	59-63
20929239-3	2010	Here, we show that the long distance tip-wear endurance issue can be resolved by introducing a thin water layer at the tip-media interface-thin enough to form a liquid crystal.	Water	100-105	TOR signaling pathway regulator	Homo sapiens	119-122
20929239-4	2010	By modulating the force at the tip-surface contact, this water crystal layer can act as a viscoelastic material which reduces the stress level on atomic bonds taking part in the wear process.	Water	57-62	TOR signaling pathway regulator	Homo sapiens	31-34
20937907-6	2010	Furthermore, Hot Tap adapts to the complex protein environment by participating in several direct and water-bridged interactions across the foldon trimer interface.	Water	102-107	filamin B	Homo sapiens	17-20
2480823-7	1989	This value agrees with that expected for a BPTI monomer hydrated with less than a monolayer of water.	Water	95-100	spleen trypsin inhibitor I	Bos taurus	43-47
20973973-7	2010	In a complex of H-Ras GppNHp (guanosine-5"-(beta,gamma-imido)-triphosphate), a second Mg2+ ion was found to be coordinated to the gamma-phosphate group of GppNHp, which positions the hydrolytically active water molecule very close to the attacked gamma-phosphorous atom.	Water	205-210	HRas proto-oncogene, GTPase	Homo sapiens	16-21
20843696-0	2010	Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta-selective partial agonists by disruption of molecular planarity/symmetry.	Water	15-20	peroxisome proliferator activated receptor alpha	Homo sapiens	57-99
2699583-1	1989	The inability to secrete the water-soluble glycoprotein form of the ABO blood group antigens is a genetic characteristic associated with susceptibility to superficial fungal infections and also insulin-dependent diabetes mellitus (IDDM).	Water	29-34	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	68-83
20843696-0	2010	Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta-selective partial agonists by disruption of molecular planarity/symmetry.	Water	15-20	peroxisome proliferator activated receptor alpha	Homo sapiens	101-105
2592208-7	1989	A mean tap water 222Rn content of 38.3 Bq L-1 and 10.4 Bq L-1 was measured in 31 villages with a crystalline subsoil and 73 villages with a sedimentary subsoil, respectively.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
20668095-3	2010	Osmolality is known to contribute to the regulation of collecting duct water (aquaporin-2; AQP2) and urea transporter (UT-A1, UT-A3) regulation.	Water	71-76	aquaporin 2	Mus musculus	78-89
2592208-8	1989	Radon-222 degasing from the tap water into the indoor air leads to an additional exposure of about 0.11 mSv y-1 and 0.03 mSv y-1 in homes with a crystalline subsoil and homes with a sedimentary subsoil, respectively.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
2552917-1	1989	Pig pancreas carboxypeptidase B has been immobilized by covalent attachment to a polyacrylamide-type bead support possessing carboxylic functional groups activated by water-soluble carbodiimide.	Water	167-172	carboxypeptidase B1	Sus scrofa	13-31
20668095-3	2010	Osmolality is known to contribute to the regulation of collecting duct water (aquaporin-2; AQP2) and urea transporter (UT-A1, UT-A3) regulation.	Water	71-76	aquaporin 2	Mus musculus	91-95
20195664-1	2010	The energetics of the mechanism of proton transfer from a hydronium ion to one of the water molecules in its first solvation shell are studied using density functional theory and the Moller-Plesset perturbation (MP2) method.	Water	86-91	tryptase pseudogene 1	Homo sapiens	212-215
2507476-2	1989	Researchers have suggested that the increased longitudinal relaxation rates (1/T1) of solvent water protons often found in melanoma result either from the paramagnetism of stable free radicals occurring in melanin or from that of methemoglobin in nonacute hemorrhagic regions of the tumor.	Water	94-99	hemoglobin subunit gamma 2	Homo sapiens	230-243
20809577-0	2010	Water diffusion behaviors and transportation properties in transmembrane cyclic hexa-, octa- and decapeptide nanotubes.	Water	0-5	hexosaminidase subunit alpha	Homo sapiens	80-84
2792238-8	1989	The water content of the lens is enhanced only in the homozygous Scat mutants.	Water	4-9	dominant cataract 2	Mus musculus	65-69
2792238-9	1989	Biochemically, the lenticular content of water-soluble proteins is decreased in the homozygous Scat mutants.	Water	41-46	dominant cataract 2	Mus musculus	95-99
20638103-11	2010	Obtained results for organic and elemental carbon fluxes showed that atmospheric aerosols can be treated, along with water run-off, as a carbon source for the coastal waters of the Baltic Sea.	Water	117-122	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	188-191
2792238-10	1989	By electrophoresis, in the lenses of homozygous Scat mutants a different pattern of water-soluble proteins could be observed.	Water	84-89	dominant cataract 2	Mus musculus	48-52
2789441-3	1989	The binding of HD11 to T-2 conjugated to bovine serum albumin was inhibited by free T-2 toxin but not by the water-soluble heterocyclic guanidines saxitoxin and tetrodotoxin.	Water	109-114	solute carrier family 25 member 5	Homo sapiens	23-26
20619274-8	2010	KEY FINDINGS: Trx mutated at T100 causes lower survival rate induced by H(2)O(2), and higher apoptosis rate induced by cis-platinum and adriamycin in HepG2 cells.	Water	72-77	thioredoxin	Homo sapiens	14-17
2501305-9	1989	These results support the proposal of Pocker and Janjic and the suggested role of histidine 64 in carbonic anhydrase II as a proton shuttle residue that transfers a proton from zinc-bound water to buffer in solution.	Water	188-193	carbonic anhydrase 2	Homo sapiens	98-119
20684645-0	2010	(2)H NMR study of the water dynamics in hydrated myoglobin.	Water	22-27	myoglobin	Homo sapiens	49-58
20648008-2	2010	Sodium selenate is a small, water-soluble, orally bioavailable activator of PP2A phosphatase with anti-angiogenic properties.	Water	28-33	protein phosphatase 2 phosphatase activator	Homo sapiens	76-80
20394832-6	2010	The GABA transport inhibitor SKF 89976A inhibited both GABA transport and water movement induced by the expression of GAT1.	Water	74-79	solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog	Xenopus laevis	118-122
20394832-8	2010	In particular the GAT1 mutant Q291N, void of any transport activity, induced a water permeability similar to that induced by the wt protein.	Water	79-84	solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog	Xenopus laevis	18-22
20551911-7	2010	Mice receiving rAAV1-Abeta-scFv harbored lower levels of insoluble Abeta and hyperphosphorylated tau, and exhibited improved cognitive function as measured by the Morris Water Maze (MWM) spatial memory task.	Water	170-175	amyloid beta (A4) precursor protein	Mus musculus	21-26
20461024-10	2010	One possible mechanism of Epo for decreasing brain edema and cellular swelling could be a better clearance of water excess in brain tissue, a process possibly mediated by AQP4.	Water	110-115	erythropoietin	Rattus norvegicus	26-29
20461024-10	2010	One possible mechanism of Epo for decreasing brain edema and cellular swelling could be a better clearance of water excess in brain tissue, a process possibly mediated by AQP4.	Water	110-115	aquaporin 4	Rattus norvegicus	171-175
20497376-3	2010	Plastid terminal oxidase (PTOX) accepts electrons from PQ and transfers them to oxygen to produce water.	Water	98-103	Alternative oxidase family protein	Arabidopsis thaliana	0-24
20497376-3	2010	Plastid terminal oxidase (PTOX) accepts electrons from PQ and transfers them to oxygen to produce water.	Water	98-103	Alternative oxidase family protein	Arabidopsis thaliana	26-30
20968063-2	2010	Specifically it describes: 1) the effects of 5-HT1A and 5-HT1B receptors on aggressive behavior, sexual arousal, food and water consumption; 2) the data showing reciprocal effect of 5-HT2A, 5-HT2C receptor agonists; 3) interaction of 5-HT3 and 5-HT1A-receptors in 5-HT3-induced hypothermia.	Water	122-127	5-hydroxytryptamine receptor 1A	Homo sapiens	45-51
20590081-1	2010	In this paper we report the geometries and properties of 24 structural isomers located on the MP2/6-311++g** potential energy surface of the water hexamer.	Water	141-146	tryptase pseudogene 1	Homo sapiens	94-97
21081887-7	2010	However, LiF, Si and A12O3 show enhanced response and diamond shows decreased response in PMMA and polystyrene phantoms than in water.	Water	128-133	LIF interleukin 6 family cytokine	Homo sapiens	9-12
20557108-0	2010	Binuclear hexa- and pentavalent uranium complexes with a polypyrrolic ligand: a density functional study of water- and hydronium-induced reactions.	Water	108-113	hexosaminidase subunit alpha	Homo sapiens	10-14
20353820-7	2010	We also found that caveolin-1 overexpression increased NO generation in response to shear stress but only in the presence of H(2)O(2).	Water	125-130	caveolin 1	Bos taurus	19-29
20568751-4	2010	Instead, our results indicated that HDAC8 employs a proton-shuttle catalytic mechanism, in which a neutral His143 first serves as the general base to accept a proton from the zinc-bound water molecule in the initial rate-determining nucleophilic attack step, and then shuttles it to the amide nitrogen atom to facilitate the cleavage of the amide bond.	Water	186-191	histone deacetylase 8	Homo sapiens	36-41
21037969-4	2010	Soluble ABri molecules present in the circulation of carriers of the BRI2 mutation are 34 amino acids long exclusively harboring Glu residue at the N-termini (ABri1-34E), whereas water- and formic acid-soluble ABri molecules extracted from FBD brains have abundant ABri species bearing pGlu residue (ABri1-34pE), suggesting that pyroglutamate formation occurs at the site of deposition.	Water	179-184	integral membrane protein 2B	Homo sapiens	8-12
21037969-4	2010	Soluble ABri molecules present in the circulation of carriers of the BRI2 mutation are 34 amino acids long exclusively harboring Glu residue at the N-termini (ABri1-34E), whereas water- and formic acid-soluble ABri molecules extracted from FBD brains have abundant ABri species bearing pGlu residue (ABri1-34pE), suggesting that pyroglutamate formation occurs at the site of deposition.	Water	179-184	integral membrane protein 2B	Homo sapiens	69-73
20043149-8	2010	Taken together, increased cell swelling and reduced water diffusion caused by elevated O-GlcNAc show notable analogy to the regulatory volume changes seen by magnetic resonance methods in nervous and other tissues in different pathological states.	Water	52-57	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	87-95
20451280-3	2010	We aimed to determine whether aquaporin-4 (AQP4), an astrocyte endfeet bi-directional water channel, is associated with the brain oedema of HE.	Water	86-91	aquaporin 4	Rattus norvegicus	30-41
20451280-3	2010	We aimed to determine whether aquaporin-4 (AQP4), an astrocyte endfeet bi-directional water channel, is associated with the brain oedema of HE.	Water	86-91	aquaporin 4	Rattus norvegicus	43-47
20390303-1	2010	The aim of this study was to determine (1) whether ibuprofen treatment in very preterm infants causes an increase in the renal water channel aquaporin-2 (AQP2) activity in the collecting duct via prostaglandin synthesis inhibition and (2) whether AQP2 activity remains disturbed long after ibuprofen treatment has ended.	Water	127-132	aquaporin 2	Homo sapiens	141-152
20390303-1	2010	The aim of this study was to determine (1) whether ibuprofen treatment in very preterm infants causes an increase in the renal water channel aquaporin-2 (AQP2) activity in the collecting duct via prostaglandin synthesis inhibition and (2) whether AQP2 activity remains disturbed long after ibuprofen treatment has ended.	Water	127-132	aquaporin 2	Homo sapiens	154-158
20609405-2	2010	If you imagine yourself as a castaway on an island you might pick water, glucose, penicillin, and ethanol in combination with aspirin.	Water	66-71	protein interacting with PRKCA 1	Homo sapiens	61-65
21587943-1	2010	In the structure of the title compound, C(7)H(10)NO(+) PF(6) (-) H(2)O, the protonated 4-meth-oxy-anilinium cations and hexa-fluoro-phosphate anions are bridged by the water mol-ecule via N-H O and O-H F hydrogen bonds.	Water	168-173	hexosaminidase subunit alpha	Homo sapiens	120-124
2787112-6	1989	Tap water drinkers whose home source of water included ground water had the greatest risk (13.8) and, after controlling for confounders, their hazard ratio was 1.7.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
2787112-6	1989	Tap water drinkers whose home source of water included ground water had the greatest risk (13.8) and, after controlling for confounders, their hazard ratio was 1.7.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	0-3
2787112-6	1989	Tap water drinkers whose home source of water included ground water had the greatest risk (13.8) and, after controlling for confounders, their hazard ratio was 1.7.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	0-3
2787112-7	1989	Based on external data from comparable studies, bottled water drinkers appeared to have had unusually low risks, and tap water drinkers who received ground water may have had slightly high risks.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
20559440-7	2010	Clustering of Wsc1 is strongly enhanced in deionized water or at elevated temperature, suggesting its relevance in proper stress response.	Water	53-58	Slg1p	Saccharomyces cerevisiae S288C	14-18
2787112-7	1989	Based on external data from comparable studies, bottled water drinkers appeared to have had unusually low risks, and tap water drinkers who received ground water may have had slightly high risks.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
2544230-5	1989	Our results and most of the findings of earlier studies on the spin-state transitions of aquomethemoglobin, using susceptibility, optical, or EPR measurements, can be explained by the transition of methemoglobin with H2O as ligand (with high-spin state at all temperatures) and methemoglobin with ligand N epsilon of His E7 (with a low-spin ground state).	Water	217-220	hemoglobin subunit gamma 2	Homo sapiens	93-106
2544230-5	1989	Our results and most of the findings of earlier studies on the spin-state transitions of aquomethemoglobin, using susceptibility, optical, or EPR measurements, can be explained by the transition of methemoglobin with H2O as ligand (with high-spin state at all temperatures) and methemoglobin with ligand N epsilon of His E7 (with a low-spin ground state).	Water	217-220	hemoglobin subunit gamma 2	Homo sapiens	198-211
20527030-8	2010	H(2)O binding to metmyoglobin (17,585 Da), where the heme iron is in the ferric oxidation state, is observed in ESI-MS. CO binding to Mb (17,595 Da), on the other hand, can be only observed after the heme iron is reduced to the ferrous form.	Water	0-5	myoglobin	Homo sapiens	134-136
2638964-3	1989	The maximum stress due to the hygroscopic examination of the composite was 0.74 kg/mm2 at equilibrium of the water absorbed of the composite.	Water	109-114	PNMA family member 2	Homo sapiens	83-86
20373292-2	2010	Their zeta potential data in methanol and ACN as well as in methanol-water and ACN-water solution were obtained using Zetasizer.	Water	83-88	apoptotic chromatin condensation inducer 1	Homo sapiens	79-82
2553424-2	1989	In rats ANP was also found to influence water and electrolyte transport in the small intestine.	Water	40-45	natriuretic peptide A	Rattus norvegicus	8-11
20392096-6	2010	Another issue of the method is the polyhedral protein/water interface area (PIA) which quantifies the exposure of atoms or residues to the solvent.	Water	54-59	RPTOR independent companion of MTOR complex 2	Homo sapiens	76-79
2547896-4	1989	These isomers presumably represent syn- and anti-arrangement of coordinated water and adenosine.	Water	76-81	synemin	Homo sapiens	35-38
20424115-8	2010	Pretreatment of cells with catalase, a scavenger of H(2)O(2), significantly decreased RET/PTC1 rearrangement formation.	Water	52-57	ret proto-oncogene	Homo sapiens	86-89
2780791-3	1989	Neurotensin produced a significant and dose-dependent increase in water intake when injected into the ventricular system but had no effect when it was applied to the other brain sites.	Water	66-71	neurotensin	Rattus norvegicus	0-11
20445050-0	2010	The amiloride-sensitive epithelial Na+ channel PPK28 is essential for drosophila gustatory water reception.	Water	91-96	pickpocket 28	Drosophila melanogaster	47-52
2721007-1	1989	Trihalomethanes (THM) present in tap water were also found in dialysis fluid because they were not eliminated by water treatment.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
20445050-4	2010	Deletion of the gene that encodes the amiloride-sensitive PPK28 channel, a DEG/eNaC (degenerin/epithelial sodium channel) family member, abolished the water-induced activity of water gustatory receptor neurons and greatly diminished the behavioral response of flies to water.	Water	151-156	pickpocket 28	Drosophila melanogaster	58-63
20445050-4	2010	Deletion of the gene that encodes the amiloride-sensitive PPK28 channel, a DEG/eNaC (degenerin/epithelial sodium channel) family member, abolished the water-induced activity of water gustatory receptor neurons and greatly diminished the behavioral response of flies to water.	Water	177-182	pickpocket 28	Drosophila melanogaster	58-63
2526789-3	1989	ANP injections at the doses of 1, 5, 25 and 50 micrograms/kg increased water and sodium excretion significantly at all but the lowest dose in the controls; only the two largest doses caused clear diuresis and natriuresis in the heart failure group.	Water	71-76	natriuretic peptide A	Rattus norvegicus	0-3
20445050-5	2010	Ectopic expression of the PPK28 channel in the bitter cells within the intermediate-type sensilla renders these sensilla responsive to water stimuli.	Water	135-140	pickpocket 28	Drosophila melanogaster	26-31
20445050-6	2010	Thus, the amiloride-sensitive PPK28 channel may serve as the osmolarity sensor for gustatory water reception in the fruit fly.	Water	93-98	pickpocket 28	Drosophila melanogaster	30-35
20385653-5	2010	We show that after a chronic 8 week treatment, benfotiamine dose-dependently enhanced the spatial memory of amyloid precursor protein/presenilin-1 mice in the Morris water maze test.	Water	166-171	presenilin 1	Mus musculus	134-146
2713361-0	1989	Transition-state stabilization by adenosine deaminase: 1,6-addition of water to purine ribonucleoside, the enzyme"s affinity for 6-hydroxy-1,6-dihydropurine ribonucleoside, and the effective concentration of substrate water at the active site.	Water	71-76	adenosine deaminase	Homo sapiens	34-53
21130959-4	2010	Rather, the defect is the maintained permeability of kidney aquaporin-2 channels to water.	Water	84-89	aquaporin 2	Homo sapiens	60-71
2713361-0	1989	Transition-state stabilization by adenosine deaminase: 1,6-addition of water to purine ribonucleoside, the enzyme"s affinity for 6-hydroxy-1,6-dihydropurine ribonucleoside, and the effective concentration of substrate water at the active site.	Water	218-223	adenosine deaminase	Homo sapiens	34-53
20512452-1	2010	Aquaporin-1 (AQP1) is a water channel protein expressed in endothelial and epithelial cells of many tissues, including the vasculature, where it serves to increase water permeability of the cell membrane.	Water	24-29	aquaporin-1	Oryctolagus cuniculus	0-11
2521777-8	1989	The attenuated renal response to ANP may contribute to the impaired sodium and water excretion in chronic heart failure, although other mechanisms are involved.	Water	79-84	natriuretic peptide A	Rattus norvegicus	33-36
2720096-16	1989	The distortion of the helix exposes C = O(Aib1) and C = O(Aib4) to the outside environment with the consequence of attracting additional water molecules.	Water	137-142	ANIB1	Homo sapiens	42-46
20512452-1	2010	Aquaporin-1 (AQP1) is a water channel protein expressed in endothelial and epithelial cells of many tissues, including the vasculature, where it serves to increase water permeability of the cell membrane.	Water	24-29	aquaporin-1	Oryctolagus cuniculus	13-17
20512452-5	2010	This correlated well with the pattern of neovascularization and increased water content of infarct border tissue, and suggested that AQP1 may be involved in myocardial angiogenesis in response to ischemia injury.	Water	74-79	aquaporin-1	Oryctolagus cuniculus	133-137
20129615-0	2010	Aqueous coating dispersion (pseudolatex) of zein improves formulation of sustained-release tablets containing very water-soluble drug.	Water	115-120	zein	Zea mays	44-48
2524370-7	1989	The development of a radioimmunoassay for ANF determination in the plasma of rats and man enabled us to follow up its changes under various experimental conditions (water deprivation, increased or decreased salt intake, effect of anaesthetics, ontogenetic changes in ANF concentration during development of hypertension in the spontaneously hypertensive rat) and in clinical studies (effect of ECV expansion in controls, arterial hypertension, liver cirrhosis as well as ANF changes in congestive heart failure or chronic renal failure).	Water	165-170	natriuretic peptide A	Rattus norvegicus	42-45
2768821-2	1989	The serovar 05 K17 was virtually present in all water samples and was also isolated from a case of purulent ear infection in a child from Burgas.	Water	48-53	keratin 17	Homo sapiens	15-18
20129615-3	2010	The novel plasticized film-coating pseudolatex of zein was studied in formulation of sustained-release tablets containing very water-soluble drug.	Water	127-132	zein	Zea mays	50-54
20129615-11	2010	The aqueous zein-coated tablets containing very water-soluble drug (metoprolol tartrate) exhibited clear sustained-release dissolution profiles in vitro, while the respective solvent-based film-coated tablets showed much faster drug release.	Water	48-53	zein	Zea mays	12-16
2785600-2	1989	In 8 sequential trials, 90 Louvain (LOU) rats and 91 Sprague-Dawley (SD) rats were immunized with chick type II collagen and given amiprilose HC1 in water (1 mg/ml) or water alone.	Water	149-154	Hypercalciuria QTL 1	Rattus norvegicus	142-145
20129615-12	2010	Furthermore, aqueous zein-coated tablets had lower water absorption at high humidity conditions.	Water	51-56	zein	Zea mays	21-25
20129615-13	2010	In conclusion, the plasticized aqueous dispersion (pseudolatex) of zein can be used for moisture resistant film coating of sustained-release tablets containing very water-soluble drug.	Water	165-170	zein	Zea mays	67-71
19423319-9	2010	In addition, water-soluble extracts of Mukitake powder showed an inhibitory effect on inhibitor of kappaB (IkappaB) kinase (IKK) beta, whose activation is required for nuclear factor kappaB (NFkappaB)-mediated inflammatory response.	Water	13-18	inhibitor of kappaB kinase beta	Mus musculus	83-133
2521394-3	1989	Our findings suggest that atrial natriuretic factor exerts its centrally mediated effects on sodium and water metabolism, at least in part, via a dopaminergic mechanism.	Water	104-109	natriuretic peptide A	Rattus norvegicus	26-51
19910044-2	2010	In addition to the water exchange between the basins, its waters are influenced by runoff, and thus the sea area has both sill and estuarine characteristics.	Water	19-24	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	104-107
3064641-5	1988	On the alcohol night there was a significant increase in the CPAP pressure required to eliminate snoring (placebo 4.8 +/- 1.7 cm H2O, alcohol 6.2 +/- 1.5 cm H2O).	Water	129-132	centromere protein J	Homo sapiens	61-65
3064641-5	1988	On the alcohol night there was a significant increase in the CPAP pressure required to eliminate snoring (placebo 4.8 +/- 1.7 cm H2O, alcohol 6.2 +/- 1.5 cm H2O).	Water	157-160	centromere protein J	Homo sapiens	61-65
20669661-6	2010	The changes of AQP5"s distribution can cause accumulation of water in nasal polyps, HIF-1alpha, VEGF can induce new blood vessels and increase vasopermeability in nasal polyps; they have separate regulatory mechanism in edema formation, but might have some relationships in some ways.	Water	61-66	aquaporin 5	Homo sapiens	15-19
2977195-2	1988	Administration of synthetic atrial natriuretic factor (150 micrograms/kg/day) to rats made hypertensive by 7-day infusion of aldosterone (100 micrograms/kg/day) and sodium loading with 1% NaCl as drinking water returned the blood pressure to control levels, and the antihypertensive effect was not associated with any changes in urine volume and urinary sodium excretion.	Water	205-210	natriuretic peptide A	Rattus norvegicus	28-53
2592496-6	1989	This washing procedure however is more effective for tap-water than for surface water samples.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
20189307-6	2010	Effect of water confining between the tip and a mica substrate is discussed.	Water	10-15	TOR signaling pathway regulator	Homo sapiens	38-41
2592496-8	1989	Detection limits in surface water samples are 0.1-0.5 micrograms/l whereas those in tap water are 10-50 ng/l.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
2851333-0	1988	Hydration of CO2 by carbonic anhydrase: intramolecular proton transfer between Zn2+-bound H2O and histidine 64 in human carbonic anhydrase II.	Water	90-93	carbonic anhydrase 2	Homo sapiens	120-141
2851333-1	1988	The energy barrier for the intramolecular proton transfer between zinc-bound water and His 64 in the active site of human carbonic anhydrase II (HCA II) has been studied at the partial retention of diatomic differential overlap (PRDDO) level.	Water	77-82	carbonic anhydrase 2	Homo sapiens	122-143
2810505-2	1989	The magnesium-to-calcium ratio in tap water correlated negatively with the incidence of urolithiasis.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
20095556-6	2010	In particular, for myoglobin it was found that a water molecule can (i) "block" entry/escape of ligands to/from a particular docking site, (ii) act as a "wedge" modulating the dynamics of internal cavities, or (iii) join a "flow" of waters taking a ligand into (or "washing" a ligand away from) the protein interior.	Water	49-54	myoglobin	Homo sapiens	19-28
2813454-1	1989	Xenopus oocytes were injected with size-fractionated mRNA isolated from the renal cortex of rabbit kidney and after 4 days incubation, PAH uptake in oocytes injected with mRNA (0.7-1.3 kb) was 8 to 45 fold that of the water injected controls.	Water	218-223	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	135-138
2973249-6	1988	In rats in the water-deprived state, the low dose of ANP caused a marked fall in MAP but only a transient increase in HR; there was marked hindquarters vasodilation.	Water	15-20	natriuretic peptide A	Rattus norvegicus	53-56
3248218-2	1988	In some energy minima corresponding to the arrangement of the bases with one of the bases being in the syn-orientation with respect to the sugar two bases are linked through one H-bond and one or two water bridges.	Water	200-205	synemin	Homo sapiens	103-106
20168076-4	2010	Investigating the possible connection between AQP1 and cytoskeleton, our group showed that such a water channel through Lin7/beta-catenin affects the organization of the cytoskeleton and proposed a model.	Water	98-103	lin-7 homolog A, crumbs cell polarity complex component	Homo sapiens	120-124
3183057-7	1988	Normalization of the markedly elevated glomerular capillary pressure (PGC) in these glomeruli was accomplished by acute intravenous infusion of verapamil, which decreased SNGFRAlb by 9-83% without affecting the single nephron filtration rate of water (SNGFRH2O).	Water	245-250	progastricsin	Rattus norvegicus	70-73
2597762-2	1989	120 mg/kg, was found to produce markedly protective effects in a rat model of coronary occlusive myocardial infarction, whereas the water soluble BAT analogue, 4-Oxy-3,5-ditretbutylphenyl phosphonic acid sodiate (SFN-6), 100 mg/kg, displayed no protective effects.	Water	132-137	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	146-149
20168076-4	2010	Investigating the possible connection between AQP1 and cytoskeleton, our group showed that such a water channel through Lin7/beta-catenin affects the organization of the cytoskeleton and proposed a model.	Water	98-103	catenin beta 1	Homo sapiens	125-137
20803427-2	2010	Uptake of (14)C-BT increased after a 20-minute exposure to 1 % (v/v) distilled water, and, compared to distilled water, it was decreased by Pedras Salgadas((R)) 1 % (v/v) and Melgaco((R)) 5 % (v/v), and increased by Vidago((R)) 5 % (v/v).	Water	79-84	opsin 1, short wave sensitive	Homo sapiens	14-18
2768238-0	1989	Reaction of lecithin cholesterol acyltransferase with water-soluble substrates.	Water	54-59	lecithin-cholesterol acyltransferase	Homo sapiens	12-48
2768238-1	1989	To separate the interfacial and catalytic reactions of lecithin cholesterol acyltransferase (LCAT), we carried out the first investigation of its reaction with water-soluble substrates.	Water	160-165	lecithin-cholesterol acyltransferase	Homo sapiens	55-91
2768238-1	1989	To separate the interfacial and catalytic reactions of lecithin cholesterol acyltransferase (LCAT), we carried out the first investigation of its reaction with water-soluble substrates.	Water	160-165	lecithin-cholesterol acyltransferase	Homo sapiens	93-97
2769506-6	1989	We found that (1) total pulmonary resistance, significantly higher in infants with bronchopulmonary dysplasia than in control infants, decreased from 206.1 +/- 47 cm H2O.L-1.sec-1 during inhalation of room air to 106.5 +/- 20.9 during inhalation of 100% oxygen (p less than 0.05) and (2) pulmonary dynamic compliance, lower in infants with bronchopulmonary dysplasia than in control infants, increased significantly with the administration of 100% oxygen.	Water	166-169	secretory blood group 1, pseudogene	Homo sapiens	174-179
2844855-0	1988	Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.	Water	66-71	natriuretic peptide A	Rattus norvegicus	0-25
3166426-3	1988	Ca1 is in near-ideal pentagonal bipyramidal configuration with Asp200 carboxylate and Pro175 peptide C = O in an apical, and Val177 peptide C = O and four water molecules in an equatorial position, whereas Ca2 displays incomplete octahedral coordination with the carboxylate of Asp260, the peptide C = O of Val16 and the two water molecules.	Water	155-160	carbonic anhydrase 1	Homo sapiens	0-3
3166426-3	1988	Ca1 is in near-ideal pentagonal bipyramidal configuration with Asp200 carboxylate and Pro175 peptide C = O in an apical, and Val177 peptide C = O and four water molecules in an equatorial position, whereas Ca2 displays incomplete octahedral coordination with the carboxylate of Asp260, the peptide C = O of Val16 and the two water molecules.	Water	325-330	carbonic anhydrase 1	Homo sapiens	0-3
20305644-2	2010	An energy-efficient approach to converting sea water into fresh water could be of substantial benefit, but current desalination methods require high power consumption and operating costs or large-scale infrastructures, which make them difficult to implement in resource-limited settings or in disaster scenarios.	Water	47-52	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	43-46
22148669-0	1988	Indoor particle concentrations associated with use of tap water in portable humidifiers.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
20305644-3	2010	Here, we report a process for converting sea water (salinity approximately 500 mM or approximately 30,000 mg l(-1)) to fresh water (salinity &lt;10 mM or &lt;600 mg l(-1)) in which a continuous stream of sea water is divided into desalted and concentrated streams by ion concentration polarization, a phenomenon that occurs when an ion current is passed through ion-selective membranes.	Water	45-50	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	41-44
20305644-3	2010	Here, we report a process for converting sea water (salinity approximately 500 mM or approximately 30,000 mg l(-1)) to fresh water (salinity &lt;10 mM or &lt;600 mg l(-1)) in which a continuous stream of sea water is divided into desalted and concentrated streams by ion concentration polarization, a phenomenon that occurs when an ion current is passed through ion-selective membranes.	Water	45-50	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	204-207
20305644-3	2010	Here, we report a process for converting sea water (salinity approximately 500 mM or approximately 30,000 mg l(-1)) to fresh water (salinity &lt;10 mM or &lt;600 mg l(-1)) in which a continuous stream of sea water is divided into desalted and concentrated streams by ion concentration polarization, a phenomenon that occurs when an ion current is passed through ion-selective membranes.	Water	125-130	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	41-44
16347719-13	1988	(i) CCP is a key enzyme of H(2)O(2) detoxification in yeasts.	Water	27-32	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	4-7
20305644-3	2010	Here, we report a process for converting sea water (salinity approximately 500 mM or approximately 30,000 mg l(-1)) to fresh water (salinity &lt;10 mM or &lt;600 mg l(-1)) in which a continuous stream of sea water is divided into desalted and concentrated streams by ion concentration polarization, a phenomenon that occurs when an ion current is passed through ion-selective membranes.	Water	125-130	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	204-207
2560911-0	1989	Atrial natriuretic peptide: water and electrolyte homeostasis.	Water	28-33	natriuretic peptide A	Rattus norvegicus	0-26
20305644-3	2010	Here, we report a process for converting sea water (salinity approximately 500 mM or approximately 30,000 mg l(-1)) to fresh water (salinity &lt;10 mM or &lt;600 mg l(-1)) in which a continuous stream of sea water is divided into desalted and concentrated streams by ion concentration polarization, a phenomenon that occurs when an ion current is passed through ion-selective membranes.	Water	125-130	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	41-44
20186756-3	2010	Thyroglobulin was digested by trypsin in distilled water and the resulting peptides were identified by TOF-secondary ion mass spectrometry, using TFA as a matrix to catalyze the ionization of the peptides.	Water	51-56	thyroglobulin	Sus scrofa	0-13
2792084-8	1989	O-2 is hydrogen-bonded through a water molecule to an adjacent asymmetric unit.	Water	33-38	immunoglobulin kappa variable 1D-39	Homo sapiens	0-3
3220764-0	1988	[Home treatment of hyperhidrosis of the hands and feet tap water iontophoresis].	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
20117817-3	2010	RARalpha agonistic activity was commonly detected in the surface water samples collected along two rivers at different periods, with maximum all-trans retinoic acid (atRA) equivalents of 47.6 ng-atRA/L and 23.5 ng-atRA/L being observed in Lake Biwa-Yodo River and Ina River, respectively.	Water	65-70	retinoic acid receptor alpha	Homo sapiens	0-8
18964577-2	1988	The suggested procedure has been used for the determination of iron(III) in tap water and the accuracy investigated both by analysing standard solutions and by comparison with results obtained by atomic-absorption spectrometry.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
2745781-1	1989	Computed tomography of the gastric wall after ingestion of 500-700 ml of pure tap water, followed by rapid intravenous injection of contrast medium, was performed on 24 patients with known gastric tumors.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
2456024-1	1988	The effects of standard, fat-rich, protein-rich, and carbohydrate-rich diets combined with either long-term ethanol ingestion or tap water ingestion on the behavior of plasma phospholipase A2 activity during experimental acute pancreatitis were studied in rats.	Water	133-138	SEC14-like lipid binding 2	Rattus norvegicus	129-132
20217429-12	2010	Enhanced expression of aquaporin 2 in medullary collecting tubules is probably an attempt to retain water during the nonoliguric phase of renal failure.	Water	100-105	aquaporin 2	Homo sapiens	23-34
2530654-1	1989	Tap water fluoridation was juxtaposed to the incidence of dental caries among children residents of Stavropol Territory.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
20089852-3	2010	Transgenic Arabidopsis overexpressing the RPK1 protein showed increased ABA sensitivity in their root growth and stomatal closure and also displayed less transpirational water loss.	Water	170-175	receptor-like protein kinase 1	Arabidopsis thaliana	42-46
2548610-4	1989	When both IHP and BZF are added to the mixed-spin derivatives (H2O, SCN-, OCN-, and NO2-) of human methemoglobin, the spin equilibrium is shifted toward higher spin by about 700 cal/mol, similar to the spin change detected in derivatives of carp methemoglobin upon addition of IHP alone.	Water	63-66	spindlin 1	Homo sapiens	118-122
2548610-4	1989	When both IHP and BZF are added to the mixed-spin derivatives (H2O, SCN-, OCN-, and NO2-) of human methemoglobin, the spin equilibrium is shifted toward higher spin by about 700 cal/mol, similar to the spin change detected in derivatives of carp methemoglobin upon addition of IHP alone.	Water	63-66	spindlin 1	Homo sapiens	118-122
2743728-6	1989	Increasing the electrical conductivity of the tap water by adding NaCl (0.2% in weight) resulted in a decrease in amplitude to 1/100 of the direct measurement.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
3079530-3	1988	The triclinic form (P1, Z = 1) from DMSO/H2O crystallizes as a dihydrate (Karle, Sukumar &amp; Balaram (1986) Proc, Natl, Acad.	Water	41-44	crystallin gamma F, pseudogene	Homo sapiens	20-29
2900037-0	1988	Correlation between log POCT/H2O and pKB estimates for a series of muscarinic and histamine H2-receptor antagonists.	Water	29-32	histamine receptor H2	Mus musculus	82-103
20089852-10	2010	Our current data suggest therefore that RPK1 overproduction controls reactive oxygen species homeostasis and enhances both water and oxidative stress tolerance in Arabidopsis.	Water	123-128	receptor-like protein kinase 1	Arabidopsis thaliana	40-44
19931935-7	2010	The results showed that the expression of GhMYB25 and GhEXP1 showed significant difference in XinFLM after -1 DPA ovule treated for 24h relative to the untreated or H2O-treated ovules, with the expression of GhMYB25 increased significantly and that of GhEXP1 decreased.	Water	165-168	transcription factor MYB106	Gossypium hirsutum	42-49
3168427-2	1988	Potential risk factors included corticosteroid therapy and the use of warm tap water compresses at the site of intravenous catheter-related phlebitis.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
2715833-4	1989	We therefore gave the patient 99mTc-labeled sulfur colloid and tap water through his nasogastric tube.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
19694445-4	2010	High-level electronic structure calculations at the MP2 level of theory with basis sets up to quadruple-zeta quality suggest that the endo-isomer (water inside the C4A cavity) is approximately 1100 cm(-1) more stable than the exo-isomer (water hydrogen bonded to the rim of C4A).	Water	147-152	tryptase pseudogene 1	Homo sapiens	52-55
2503642-8	1989	Further study with a larger sample is needed to determine the effects of using tap water rather than sterile water as diluent.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
3420797-0	1988	[High molecular weight L-asparaginase derivatives based on a water-soluble carboxymethyl cellulose: biological properties].	Water	61-66	asparaginase like 1	Mus musculus	23-37
3420797-1	1988	L-asparaginase, covalently bound with water-soluble CM-cellulose, exhibited the elevated antileukemic activity in mice with inoculated lymphoid leukemia L5178y as compared with the native enzyme.	Water	38-43	asparaginase like 1	Mus musculus	0-14
20216911-3	2010	This study was designed to analyze changes in the expression of AQP4 (water selective channel) and AQP9 (water and lactate channel) following ONC in the rat.	Water	70-75	aquaporin 4	Rattus norvegicus	64-68
2450644-7	1988	The feeding of tungstate in the drinking water largely depleted xanthine oxidase in mice; cytochrome P-450 levels and monooxygenase activities were not affected by tungstate treatment.	Water	41-46	xanthine dehydrogenase	Mus musculus	64-80
2784141-5	1989	Infusion of IL-2 increased Ppc (from 3.9 +/- 0.1 cm H2O at baseline to 8.8 +/- 1.1 cm H2O at 60 min for IL-2 at 2000 U/ml, p less than 0.01; and from 3.8 +/- 0.1 cm H2O at baseline to 8.9 +/- 0.6 cm H2O at 60 min for IL-2 at 10,000 U/ml, p less than 0.01.	Water	52-55	interleukin-2	Cavia porcellus	12-16
20018871-5	2010	Administration of butyrate in the drinking water stimulated GlcNAc6ST-2 expression in the mouse intestine, indicating that butyrate could serve as a regulatory molecule for the GlcNAc6ST-2 expression in vivo.	Water	43-48	carbohydrate sulfotransferase 4	Mus musculus	60-71
2784141-5	1989	Infusion of IL-2 increased Ppc (from 3.9 +/- 0.1 cm H2O at baseline to 8.8 +/- 1.1 cm H2O at 60 min for IL-2 at 2000 U/ml, p less than 0.01; and from 3.8 +/- 0.1 cm H2O at baseline to 8.9 +/- 0.6 cm H2O at 60 min for IL-2 at 10,000 U/ml, p less than 0.01.	Water	86-89	interleukin-2	Cavia porcellus	12-16
2784141-5	1989	Infusion of IL-2 increased Ppc (from 3.9 +/- 0.1 cm H2O at baseline to 8.8 +/- 1.1 cm H2O at 60 min for IL-2 at 2000 U/ml, p less than 0.01; and from 3.8 +/- 0.1 cm H2O at baseline to 8.9 +/- 0.6 cm H2O at 60 min for IL-2 at 10,000 U/ml, p less than 0.01.	Water	86-89	interleukin-2	Cavia porcellus	104-108
2784141-5	1989	Infusion of IL-2 increased Ppc (from 3.9 +/- 0.1 cm H2O at baseline to 8.8 +/- 1.1 cm H2O at 60 min for IL-2 at 2000 U/ml, p less than 0.01; and from 3.8 +/- 0.1 cm H2O at baseline to 8.9 +/- 0.6 cm H2O at 60 min for IL-2 at 10,000 U/ml, p less than 0.01.	Water	86-89	interleukin-2	Cavia porcellus	104-108
2784141-5	1989	Infusion of IL-2 increased Ppc (from 3.9 +/- 0.1 cm H2O at baseline to 8.8 +/- 1.1 cm H2O at 60 min for IL-2 at 2000 U/ml, p less than 0.01; and from 3.8 +/- 0.1 cm H2O at baseline to 8.9 +/- 0.6 cm H2O at 60 min for IL-2 at 10,000 U/ml, p less than 0.01.	Water	86-89	interleukin-2	Cavia porcellus	12-16
2784141-5	1989	Infusion of IL-2 increased Ppc (from 3.9 +/- 0.1 cm H2O at baseline to 8.8 +/- 1.1 cm H2O at 60 min for IL-2 at 2000 U/ml, p less than 0.01; and from 3.8 +/- 0.1 cm H2O at baseline to 8.9 +/- 0.6 cm H2O at 60 min for IL-2 at 10,000 U/ml, p less than 0.01.	Water	86-89	interleukin-2	Cavia porcellus	104-108
2784141-5	1989	Infusion of IL-2 increased Ppc (from 3.9 +/- 0.1 cm H2O at baseline to 8.8 +/- 1.1 cm H2O at 60 min for IL-2 at 2000 U/ml, p less than 0.01; and from 3.8 +/- 0.1 cm H2O at baseline to 8.9 +/- 0.6 cm H2O at 60 min for IL-2 at 10,000 U/ml, p less than 0.01.	Water	86-89	interleukin-2	Cavia porcellus	104-108
2784141-5	1989	Infusion of IL-2 increased Ppc (from 3.9 +/- 0.1 cm H2O at baseline to 8.8 +/- 1.1 cm H2O at 60 min for IL-2 at 2000 U/ml, p less than 0.01; and from 3.8 +/- 0.1 cm H2O at baseline to 8.9 +/- 0.6 cm H2O at 60 min for IL-2 at 10,000 U/ml, p less than 0.01.	Water	86-89	interleukin-2	Cavia porcellus	12-16
2784141-5	1989	Infusion of IL-2 increased Ppc (from 3.9 +/- 0.1 cm H2O at baseline to 8.8 +/- 1.1 cm H2O at 60 min for IL-2 at 2000 U/ml, p less than 0.01; and from 3.8 +/- 0.1 cm H2O at baseline to 8.9 +/- 0.6 cm H2O at 60 min for IL-2 at 10,000 U/ml, p less than 0.01.	Water	86-89	interleukin-2	Cavia porcellus	104-108
3401444-9	1988	In addition, surface balance measurements revealed that the adsorption of liposomal lipids to an air/water interface was enhanced by the presence of SP 5-18, negatively charged phospholipids, and 3 mM calcium.	Water	101-106	Sp5 transcription factor	Canis lupus familiaris	149-156
3259493-2	1988	Here we report that certain cyanogen bromide fragments of IRBP are capable of inducing EAU.	Water	87-90	retinol binding protein 3	Bos taurus	58-62
2784141-5	1989	Infusion of IL-2 increased Ppc (from 3.9 +/- 0.1 cm H2O at baseline to 8.8 +/- 1.1 cm H2O at 60 min for IL-2 at 2000 U/ml, p less than 0.01; and from 3.8 +/- 0.1 cm H2O at baseline to 8.9 +/- 0.6 cm H2O at 60 min for IL-2 at 10,000 U/ml, p less than 0.01.	Water	86-89	interleukin-2	Cavia porcellus	104-108
18964517-0	1988	Determination of Mo(VI) in tap-water and sea-water by differential-pulse polarography and co-flotation.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
20018871-5	2010	Administration of butyrate in the drinking water stimulated GlcNAc6ST-2 expression in the mouse intestine, indicating that butyrate could serve as a regulatory molecule for the GlcNAc6ST-2 expression in vivo.	Water	43-48	carbohydrate sulfotransferase 4	Mus musculus	177-188
20102210-0	2010	Direct synthesis of water-soluble ultrathin CdS nanorods and reversible tuning of the solubility by alkalinity.	Water	20-25	CDP-diacylglycerol synthase 1	Homo sapiens	44-47
3346541-4	1988	We report here the induction of EAU in the mouse, which has hitherto been considered a species refractory to EAU, with two retinal Ag, the retinal soluble Ag and the interphotoreceptor retinoid-binding protein.	Water	32-35	retinol binding protein 3, interstitial	Mus musculus	166-209
2545762-0	1989	Spin trapping of the superoxide anion: complications in the use of the water-soluble nitroso-aromatic reagent DBNBS.	Water	71-76	spindlin 1	Homo sapiens	0-4
3341622-3	1988	delta Pam of 40 cm H2O at 0.05 Hz were achieved by placing the subject in a 410-I body chamber connected to a large stroke volume reciprocating pump.	Water	19-22	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	6-9
20102210-1	2010	Highly water-soluble ultrathin and fluorescent CdS nanorods are directly synthesized with the assistance of PEI.	Water	7-12	CDP-diacylglycerol synthase 1	Homo sapiens	47-50
20102210-4	2010	By adjusting the alkalinity of the solution, CdS nanorods can be controlled to precipitate or redisperse in water, which is believed to stem from the variation of the charges of the capping PEI molecules.	Water	108-113	CDP-diacylglycerol synthase 1	Homo sapiens	45-48
20033966-3	2010	The first generation employed spontaneous NCA polycondensation in water without a macroinitiator; this afforded low-molecular-weight, linear poly(L-lysine) G1 with a polymerisation degree of 8 and a polydispersity index of 1.2.	Water	66-71	CEA cell adhesion molecule 6	Homo sapiens	42-45
3076447-2	1988	Numerous physical characterizations clearly demonstrate that the polypentapeptide of elastin (Val1-Pro2-Gly3-Val4-Gly5)n in water undergoes an inverse temperature transition.	Water	124-129	elastin	Homo sapiens	85-92
2965296-0	1988	Hospitalizations due to tap water scalds, 1978-1985.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
2916914-1	1989	The purpose of this study was to determine whether ultrasound treatments given with a limb immersed in tap water are as effective in heating the tendons overlying a superficial bony prominence as ultrasound treatments given with the applicator and coupling agent in direct contact with the limb.	Water	107-112	putative ABC-transporter	Sus scrofa	103-106
26617300-8	2010	To assist others in future water model parametrizations we report the MP2 near complete basis set limit energies for 840 water dimer configurations sampled from an approximate thermal ensemble at ambient conditions.	Water	27-32	tryptase pseudogene 1	Homo sapiens	70-73
2647415-4	1989	Patients with chronic renal failure are also exposed to aluminum in domestic tap-water supplies used either for drinking or, in those on dialysis treatment, in the preparation of their dialysate.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
2691199-2	1989	Bone Gla protein (BGP, osteocalcin) is a 49 residue water soluble protein and matrix Gla protein (MGP) is a 79 residue water insoluble protein.	Water	119-124	matrix Gla protein	Rattus norvegicus	78-96
2691199-2	1989	Bone Gla protein (BGP, osteocalcin) is a 49 residue water soluble protein and matrix Gla protein (MGP) is a 79 residue water insoluble protein.	Water	119-124	matrix Gla protein	Rattus norvegicus	98-101
2975142-3	1988	With these considerations in mind, we have attempted to elucidate the possible involvement of the central vasopressin (AVP) and atrial natriuretic factor (ANF) systems in the regulation of the water and ion homeostasis of the brain tissue of rats: Vasopressin-positive vascular connections, investigated by immuno-electronhistochemistry, were found in close or direct contact with brain microvessels.	Water	193-198	natriuretic peptide A	Rattus norvegicus	128-153
2975142-3	1988	With these considerations in mind, we have attempted to elucidate the possible involvement of the central vasopressin (AVP) and atrial natriuretic factor (ANF) systems in the regulation of the water and ion homeostasis of the brain tissue of rats: Vasopressin-positive vascular connections, investigated by immuno-electronhistochemistry, were found in close or direct contact with brain microvessels.	Water	193-198	natriuretic peptide A	Rattus norvegicus	155-158
2975142-7	1988	On the other hand, central administration of synthetic rat ANF (2 micrograms) prevented the water accumulation elicited in rat brain by systemic hypoosmolar fluid load, and led to a significant sodium loss from the nervous tissue by altering the capillary sodium permeability.	Water	92-97	natriuretic peptide A	Rattus norvegicus	59-62
26617300-8	2010	To assist others in future water model parametrizations we report the MP2 near complete basis set limit energies for 840 water dimer configurations sampled from an approximate thermal ensemble at ambient conditions.	Water	121-126	tryptase pseudogene 1	Homo sapiens	70-73
2463199-6	1989	The analysis (performed by the patient) involves 1) collecting urine for 24 h in a 4-L container, 2) diluting the urine with tap water to a total urine of 4 L, and 3) placing a drop of this dilution onto a slide.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
19996160-2	2010	The regulation occurs in part via control of transcription of genes coding for the water channels aquaporin-2 (Aqp2) and aquaporin-3 (Aqp3).	Water	83-88	aquaporin 3 (Gill blood group)	Rattus norvegicus	121-132
2463199-8	1989	The reliability of this system has been tested for wide changes of urine pH, volume of the drop applied to the slide, and tap water from different sources.	Water	126-131	nuclear RNA export factor 1	Homo sapiens	122-125
2827518-0	1988	Glomerular ANF receptor regulation during changes in sodium and water metabolism.	Water	64-69	natriuretic peptide A	Rattus norvegicus	11-14
2827518-2	1988	A decrease in plasma immunoreactive ANF (IR-ANF) was observed after 4 days of water deprivation or after 1 wk on a low-sodium diet, whereas animals offered 1% NaCl in their drinking water had elevated plasma ANF values.	Water	78-83	natriuretic peptide A	Rattus norvegicus	36-39
19996160-2	2010	The regulation occurs in part via control of transcription of genes coding for the water channels aquaporin-2 (Aqp2) and aquaporin-3 (Aqp3).	Water	83-88	aquaporin 3 (Gill blood group)	Rattus norvegicus	134-138
2827518-2	1988	A decrease in plasma immunoreactive ANF (IR-ANF) was observed after 4 days of water deprivation or after 1 wk on a low-sodium diet, whereas animals offered 1% NaCl in their drinking water had elevated plasma ANF values.	Water	78-83	natriuretic peptide A	Rattus norvegicus	44-47
2827518-2	1988	A decrease in plasma immunoreactive ANF (IR-ANF) was observed after 4 days of water deprivation or after 1 wk on a low-sodium diet, whereas animals offered 1% NaCl in their drinking water had elevated plasma ANF values.	Water	78-83	natriuretic peptide A	Rattus norvegicus	44-47
2691359-1	1989	The rate of hexose transport was approximately 60% lower for both the high- and the low-affinity components of hexose uptake when a glucose-6-phosphate isomerase mutant of Saccharomyces cerevisiae was preincubated with glucose, as compared with preincubation with water.	Water	264-269	glucose-6-phosphate isomerase	Saccharomyces cerevisiae S288C	132-161
20141758-6	2010	Both folded and random-coil conformations of rat amylin are observed in water and their relative stability is examined in detail.	Water	72-77	islet amyloid polypeptide	Rattus norvegicus	49-55
2473342-2	1989	Adrenalectomy increased ANP levels highly in those brain areas that control water intake (the subfornical organ and supraoptic nucleus) and in the drinking center (the perifornical nucleus and the lateral hypothalamus).	Water	76-81	natriuretic peptide A	Rattus norvegicus	24-27
2827518-3	1988	Atrial IR-ANF was lower in water-deprived and higher in sodium-restricted rats than in their respective controls.	Water	27-32	natriuretic peptide A	Rattus norvegicus	10-13
2966595-1	1988	Interest in accurate measurement of atrial natriuretic factor (ANF) in biological fluids and various tissues has been stimulated by recent data indicating the possible role of ANF in the homeostasis of salt and water.	Water	211-216	natriuretic peptide A	Rattus norvegicus	36-61
2966595-1	1988	Interest in accurate measurement of atrial natriuretic factor (ANF) in biological fluids and various tissues has been stimulated by recent data indicating the possible role of ANF in the homeostasis of salt and water.	Water	211-216	natriuretic peptide A	Rattus norvegicus	63-66
2966595-1	1988	Interest in accurate measurement of atrial natriuretic factor (ANF) in biological fluids and various tissues has been stimulated by recent data indicating the possible role of ANF in the homeostasis of salt and water.	Water	211-216	natriuretic peptide A	Rattus norvegicus	176-179
19709659-4	2010	To explore the role of apoptosis in the leaky junction pathway, TNFalpha and cycloheximide (TNFalpha/CHX) were used to induce an elevated rate of apoptosis in cultured bovine aortic endothelial cell (BAEC) monolayers and the convective fluxes of LDL and water were measured.	Water	254-259	tumor necrosis factor	Bos taurus	92-100
3277532-9	1988	A binary subcomplex consisting of cytochrome f and the Rieske iron-sulfur protein was observed under these conditions by three different methods: (a) hydroxyapatite chromatography; (b) extraction with an isopropanol/water/trifluoroacetic acid mixture; and (c) gel filtration in the presence of low SDS concentrations.	Water	216-221	apocytochrome f precursor	Spinacia oleracea	34-46
2856643-0	1988	Clonidine stimulates atrial natriuretic factor (ANF) release in water-deprived rats.	Water	64-69	natriuretic peptide A	Rattus norvegicus	21-46
2601562-2	1989	or an equivalent volume of tap water twice daily from day 6 through day 18 of gestation.	Water	31-36	lymphocyte antigen 6 complex, locus A	Mus musculus	27-30
19709659-7	2010	Water flux increased by 2.7-fold after treatment with TNFalpha/CHX, and this increase was not attenuated by treatment with Z-VAD-FMK.	Water	0-5	tumor necrosis factor	Bos taurus	54-62
2856643-0	1988	Clonidine stimulates atrial natriuretic factor (ANF) release in water-deprived rats.	Water	64-69	natriuretic peptide A	Rattus norvegicus	48-51
2856643-3	1988	Clonidine evoked an increase in plasma IR-ANF from 16.6 +/- 5.9 pg/ml to 229.5 +/- 60 pg/ml (mean +/- SEM) after 24 hr water deprivation and from 13.6 +/- 7.4 pg/ml to 104.8 +/- 21 pg/ml (mean +/- SEM) after 48 hr water deprivation.	Water	119-124	natriuretic peptide A	Rattus norvegicus	42-45
20042576-7	2010	SHP-1-deficient mast cells produced and released increased amounts of mediators and Th2 cytokines IL-4 and -13 spontaneously and in response to H(2)O(2), LPS, and Fc epsilonI cross-linking, involving c-Kit-dependent and -independent processes.	Water	144-149	heart and neural crest derivatives expressed 2	Mus musculus	84-87
2856643-3	1988	Clonidine evoked an increase in plasma IR-ANF from 16.6 +/- 5.9 pg/ml to 229.5 +/- 60 pg/ml (mean +/- SEM) after 24 hr water deprivation and from 13.6 +/- 7.4 pg/ml to 104.8 +/- 21 pg/ml (mean +/- SEM) after 48 hr water deprivation.	Water	214-219	natriuretic peptide A	Rattus norvegicus	42-45
2554099-6	1989	If the finger was moistened with tap water or saliva, there was a 100% recovery rate of virus after touching dried out droplets, as well as after touching droplets in a liquid state.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
2453176-1	1987	In the rat, the effects of an atrial natriuretic factor (ANF) (Rat, 8-33 Peninsula Lab) on body water distribution have been evaluated.	Water	96-101	natriuretic peptide A	Rattus norvegicus	30-55
2520531-1	1989	The embryotoxic and fetotoxic potential of hexavalent chromium (Cr+6) in mice was investigated by administering 250, 500, and 1000 ppm of potassium dichromate daily through drinking water during the entire gestation period.	Water	182-187	growth arrest and DNA-damage-inducible 45 gamma	Mus musculus	64-68
19729542-6	2010	CSF flow was modeled as water with a sinusoidal flow pattern in time.	Water	24-29	colony stimulating factor 2	Homo sapiens	0-3
3221068-2	1988	Current Danish treatment includes prolonged tap water irrigation of burns, which largely replaces the use of narcotics for pain control in both the inpatient and outpatient settings.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
20436745-9	2010	CSF opening pressure was 250-350 mm H2O (water) in 39 patients and was &gt;350 mm H2O in 11 patients.	Water	36-39	colony stimulating factor 2	Homo sapiens	0-3
3148961-4	1988	The activity of adenylate cyclase was measured in placental cotyledons as an indicator of AVP receptors affecting water permeability.	Water	114-119	vasopressin-neurophysin 2-copeptin	Ovis aries	90-93
3675616-3	1987	The serum cholinesterase was inhibited by all those compounds, their relative potencies being proportional to their octanol/water partition coefficients.	Water	124-129	cholinesterase	Oryctolagus cuniculus	10-24
20436745-9	2010	CSF opening pressure was 250-350 mm H2O (water) in 39 patients and was &gt;350 mm H2O in 11 patients.	Water	41-46	colony stimulating factor 2	Homo sapiens	0-3
3323013-5	1987	Infusion of insulin in this Series elicited smaller decrease in plasma potassium concentration and longer lasting hypernatremia than in dogs in water-electrolytes balance.	Water	144-149	insulin	Canis lupus familiaris	12-19
21141658-2	2010	This exchange, called submarine groundwater discharge (SGD), is comprised of terrestrial water mixed with sea water that has infiltrated coastal aquifers.	Water	38-43	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	106-109
3323953-3	1987	In fact the human finger as demonstrated by Munger and Ide (1987) can perceive sound waves when water is the coupling agent.	Water	96-101	insulin degrading enzyme	Homo sapiens	55-58
3345752-3	1988	All the tocopherol homologues used, C1, C6, C11 and alpha-tocopherol, showed a similar fluorescence emission intensity at 325 nm in cyclohexane but were almost completely self-quenched by aggregation in water.	Water	203-208	aldo-keto reductase family 1 member C4	Homo sapiens	44-47
19545648-0	2010	2H and 13C NMR studies on the temperature-dependent water and protein dynamics in hydrated elastin, myoglobin and collagen.	Water	52-57	myoglobin	Homo sapiens	100-109
3337799-7	1988	Sedimentation profiles of crosslinked cytochrome b in linear sucrose density gradients made up in H2O were identical to those of non-crosslinked controls.	Water	98-101	mitochondrially encoded cytochrome b	Homo sapiens	38-50
3337803-2	1988	We have studied the interaction of purified human erythrocyte protein 4.1 with phospholipid membranes by monitoring both the increase in surface pressure of monolayers at the air/water interface and the change in permeability in liposomes to fluorescent molecules, in the presence of protein 4.1.	Water	179-184	erythrocyte membrane protein band 4.1	Homo sapiens	50-73
3337803-2	1988	We have studied the interaction of purified human erythrocyte protein 4.1 with phospholipid membranes by monitoring both the increase in surface pressure of monolayers at the air/water interface and the change in permeability in liposomes to fluorescent molecules, in the presence of protein 4.1.	Water	179-184	erythrocyte membrane protein band 4.1	Homo sapiens	62-73
2957323-8	1987	These results indicate that endogenous atrial natriuretic peptide has an important physiological role in the regulation of hemodynamics and water-electrolyte balance.	Water	140-145	natriuretic peptide A	Rattus norvegicus	39-65
19545648-1	2010	(2)H NMR spin-lattice relaxation and line-shape analyses are performed to study the temperature-dependent dynamics of water in the hydration shells of myoglobin, elastin, and collagen.	Water	118-123	myoglobin	Homo sapiens	151-160
19595796-1	2010	The glass transition and its related dynamics of myoglobin in water and in a water-glycerol mixture have been investigated by dielectric spectroscopy and differential scanning calorimetry (DSC).	Water	62-67	myoglobin	Homo sapiens	49-58
2444253-1	1987	Solvent exchange of 18O-labeled buried water in bovine pancreatic trypsin inhibitor (BPTI), trypsin, and trypsin-BPTI complex is measured by high-precision isotope ratio mass spectrometry.	Water	39-44	spleen trypsin inhibitor I	Bos taurus	85-89
2444253-1	1987	Solvent exchange of 18O-labeled buried water in bovine pancreatic trypsin inhibitor (BPTI), trypsin, and trypsin-BPTI complex is measured by high-precision isotope ratio mass spectrometry.	Water	39-44	spleen trypsin inhibitor I	Bos taurus	113-117
2444253-5	1987	Exchange of buried waters with solvent water is complete before 10-15 s in BPTI, trypsin, and BPTI-trypsin, as well as in lysozyme and carboxypeptidase measured as controls.	Water	19-24	spleen trypsin inhibitor I	Bos taurus	94-98
3346617-3	1988	The extremities to be treated are placed in tanks containing tap water ensuring conduction fo current between epidermis and electrode.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
19595796-1	2010	The glass transition and its related dynamics of myoglobin in water and in a water-glycerol mixture have been investigated by dielectric spectroscopy and differential scanning calorimetry (DSC).	Water	77-82	myoglobin	Homo sapiens	49-58
19595796-6	2010	This is in contrast to myoglobin in water-glycerol, where the main solvent relaxation makes the strongest contribution to the calorimetric glass transition.	Water	36-41	myoglobin	Homo sapiens	23-32
2856643-9	1988	In conclusion, clonidine stimulates ANF release both in normally-hydrated and water-deprived rats.	Water	78-83	natriuretic peptide A	Rattus norvegicus	36-39
21220937-9	2010	Similarly, AQP2 staining was more intense and luminal in kidney from mice with NH(4)Cl in water but not in food.	Water	90-95	aquaporin 2	Mus musculus	11-15
3191800-0	1988	[A study on the carcinogenic risk of organic concentrates from tap water in H city].	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
3664327-1	1987	Severe hyponatraemia, hyperkalaemia and pre-renal uraemia were seen in two burn victims who were treated with repeated submersion in tap-water.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
21234324-2	2010	The water and glycerol channel aquaglyceroporin-3 (AQP3) is abundant in fetal epidermis and might influence epidermal water handling and transepidermal water flux around birth.	Water	4-9	aquaporin 3 (Gill blood group)	Rattus norvegicus	31-49
3654446-7	1987	The level of the water may be adjusted to any desired level by means of a waste line or an inlet of tap water.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	100-103
3654446-7	1987	The level of the water may be adjusted to any desired level by means of a waste line or an inlet of tap water.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
2894183-6	1987	Somatostatin inhibits the effects of the release of several of the hormones involved in water-electrolyte homeostasis.	Water	88-93	somatostatin	Homo sapiens	0-12
3662252-2	1987	Tap water in this industrial city comes from the Llobregat river and is extremely hard, with an excessive level of salts.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
21234324-2	2010	The water and glycerol channel aquaglyceroporin-3 (AQP3) is abundant in fetal epidermis and might influence epidermal water handling and transepidermal water flux around birth.	Water	4-9	aquaporin 3 (Gill blood group)	Rattus norvegicus	51-55
21234324-2	2010	The water and glycerol channel aquaglyceroporin-3 (AQP3) is abundant in fetal epidermis and might influence epidermal water handling and transepidermal water flux around birth.	Water	118-123	aquaporin 3 (Gill blood group)	Rattus norvegicus	31-49
21234324-2	2010	The water and glycerol channel aquaglyceroporin-3 (AQP3) is abundant in fetal epidermis and might influence epidermal water handling and transepidermal water flux around birth.	Water	118-123	aquaporin 3 (Gill blood group)	Rattus norvegicus	51-55
2446770-8	1987	It is concluded that galanin immunoreactivity occurs in several functionally distinct classes of enteric neurons, amongst which are neurons controlling (i) motility, (ii) intestinal blood flow, and (iii) mucosal water and electrolyte transport.	Water	212-217	galanin peptides	Cavia porcellus	21-28
21234324-2	2010	The water and glycerol channel aquaglyceroporin-3 (AQP3) is abundant in fetal epidermis and might influence epidermal water handling and transepidermal water flux around birth.	Water	118-123	aquaporin 3 (Gill blood group)	Rattus norvegicus	31-49
21234324-2	2010	The water and glycerol channel aquaglyceroporin-3 (AQP3) is abundant in fetal epidermis and might influence epidermal water handling and transepidermal water flux around birth.	Water	118-123	aquaporin 3 (Gill blood group)	Rattus norvegicus	51-55
3595525-3	1987	Animals housed in a 12-h light, 12-h dark cycle and given food and water ad libitum had a significant (P less than 0.05) 24-h variation in the level of chromatographically and immunochemically identified NT in the portal circulation while the level of NT in the systemic circulation remained unchanged.	Water	67-72	neurotensin	Rattus norvegicus	204-206
19864112-12	2010	CONCLUSION: Variations in the AQP4 and the KCNJ10/KCNJ9 region are likely to be associated with TLE, particularly TLE-FS, supporting the suggestion that perturbations of water and K(+) transport are involved in the etiopathogenesis of TLE.	Water	170-175	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	43-49
3480378-0	1987	Bladder cancer, drinking water source, and tap water consumption: a case-control study.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
3480378-3	1987	Risk of bladder cancer increased with intake level of beverages made with tap water.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
3480378-4	1987	The odds ratio (OR) for the highest vs. lowest quintile of tap water consumption was 1.43 [95% confidence interval (CI) = 1.23, 1.67; chi 2 for trend = 26.3, P less than .001].	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
3480378-8	1987	Among non-smoking respondents with tap water consumption above the population median, the OR increased with exposure duration to a level of 3.1 (CI = 1.3, 7.3; chi 2 for trend = 6.3, P = .01) for greater than or equal to 60 years of residence at places served by chlorinated surface water (vs. non-chlorinated ground water users).	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
3480378-8	1987	Among non-smoking respondents with tap water consumption above the population median, the OR increased with exposure duration to a level of 3.1 (CI = 1.3, 7.3; chi 2 for trend = 6.3, P = .01) for greater than or equal to 60 years of residence at places served by chlorinated surface water (vs. non-chlorinated ground water users).	Water	283-288	nuclear RNA export factor 1	Homo sapiens	35-38
3480378-8	1987	Among non-smoking respondents with tap water consumption above the population median, the OR increased with exposure duration to a level of 3.1 (CI = 1.3, 7.3; chi 2 for trend = 6.3, P = .01) for greater than or equal to 60 years of residence at places served by chlorinated surface water (vs. non-chlorinated ground water users).	Water	283-288	nuclear RNA export factor 1	Homo sapiens	35-38
2888811-7	1987	Our findings suggest that filling bubble humidifiers or underwater chest drains with tap water is a potential hazard and should be avoided.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	85-88
19891460-9	2009	An important new finding of this study is that the lowest energy reaction path does not correspond to either one of the pure stepwise mechanisms proposed formerly but can be described instead as a partially concerted reaction between PEP, A5P, and water.	Water	248-253	progestagen associated endometrial protein	Homo sapiens	234-237
2820477-0	1987	Proton NMR and electrophoretic studies of the covalent complex formed by cross-linking yeast cytochrome c peroxidase and horse cytochrome c with a water-soluble carbodiimide.	Water	147-152	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	93-116
20560551-5	2009	The EPR spectrum of the CAT1@CB7 complex consisting of three lines suggested that probe CAT1 is associated with host CB7 such that the nitroxide part is exposed to water.	Water	164-169	GIT ArfGAP 1	Homo sapiens	24-28
2954552-2	1987	NPY injection increased significantly IR-ANF while PYY decreased IR-ANF in the dose-response manner in normally-hydrated rats as well as in water-loaded rats.	Water	140-145	peptide YY	Rattus norvegicus	51-54
2448480-4	1987	Calculations based on the assumption that the exchange mechanism involves local unfolding lead to quantitative agreement between the calculated and experimentally measured exchange rates for 80% of the amides of BPTI that are buried or hydrogen bonded to the main-chain or to internal water molecules.	Water	285-290	spleen trypsin inhibitor I	Bos taurus	212-216
2453176-1	1987	In the rat, the effects of an atrial natriuretic factor (ANF) (Rat, 8-33 Peninsula Lab) on body water distribution have been evaluated.	Water	96-101	natriuretic peptide A	Rattus norvegicus	57-60
2954473-11	1987	These studies suggest that atrial natriuretic factor could influence the long-term control of arterial pressure by altering renal medullary hemodynamics and promoting the elimination of sodium and water.	Water	197-202	natriuretic peptide A	Rattus norvegicus	27-52
20560551-5	2009	The EPR spectrum of the CAT1@CB7 complex consisting of three lines suggested that probe CAT1 is associated with host CB7 such that the nitroxide part is exposed to water.	Water	164-169	GIT ArfGAP 1	Homo sapiens	88-92
19707218-8	2009	Therefore, ET-1-induced AQP-4 expression and cerebral water accumulation are the key factors in brain edema associated with acute water intoxication.	Water	54-59	endothelin 1	Mus musculus	11-15
2820578-12	1987	Under conditions of acute dehydration after water deprivation, as well as under conditions of chronic dehydration such as those present in homozygous Brattleboro rats, there was an up-regulation of ANP receptors in the subfornical organ.	Water	44-49	natriuretic peptide A	Rattus norvegicus	198-201
3433841-0	1987	[Assessment of ship waste water treatment facilities from the public health viewpoint].	Water	26-31	inositol polyphosphate-5-phosphatase D	Homo sapiens	15-19
19647776-8	2009	In addition, pramipexole inhibited the in vitro oligomerization of human wild-type alpha-synuclein by H(2)O(2)plus cytochrome c.	Water	102-107	synuclein, alpha	Mus musculus	83-98
3618853-0	1987	Prevention of tap water scald burns: evaluation of a multi-media injury control program.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
3654457-9	1987	(Psk - Pw), where M is metabolic heat production, W is external work, R is radiant heat exchange, C is convective heat transfer, w is skin wettedness, and Psk is water vapor pressure of fully wet skin.	Water	162-167	TAO kinase 2	Homo sapiens	1-4
2438625-1	1987	Calcofluor white (CW) is a water-soluble, colorless dye that selectively binds to beta 1-4 polysaccharides (cellulose) in fungal cell walls.	Water	27-32	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	82-90
2821276-5	1987	The refined model of tonin consists of 227 amino acid residues out of the 235 in the complete molecule, 149 water molecules, and one zinc ion.	Water	108-113	kallikrein 1-related peptidase C2	Rattus norvegicus	21-26
3654457-9	1987	(Psk - Pw), where M is metabolic heat production, W is external work, R is radiant heat exchange, C is convective heat transfer, w is skin wettedness, and Psk is water vapor pressure of fully wet skin.	Water	162-167	TAO kinase 2	Homo sapiens	155-158
19881273-5	2009	Freeze-drying of BSA at different concentrations indicated retention of the secondary structure at similar monosodium citrate/protein concentration ratios, suggesting stabilization through direct interaction that substitute water molecules inevitable for the conformation integrity.	Water	224-229	albumin	Bos taurus	17-20
3613009-5	1987	Control was easily obtained by insertion of a 0.2-micron polymer filter into the outflow tubing of our pathology tap water-deionizing unit and the tap water source in the bronchoscopy suite.	Water	117-122	nuclear RNA export factor 1	Homo sapiens	113-116
3613009-5	1987	Control was easily obtained by insertion of a 0.2-micron polymer filter into the outflow tubing of our pathology tap water-deionizing unit and the tap water source in the bronchoscopy suite.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
3106477-6	1987	Yet, such lymphocytes did recognize the nonimmunizing IRBP when activated in culture for acquiring the capacity to adoptively transfer EAU into naive recipients.	Water	135-138	retinol binding protein 3	Rattus norvegicus	54-58
19657052-6	2009	A direct role for the upregulation of polyamine synthesis in the development of the priapic-like condition was supported by the observation that the ODC inhibitor 1,3-diaminopropane, when added to the drinking water of animals treated with plasmids expressing opiorphins, prevented experimental priapism.	Water	210-215	ornithine decarboxylase 1	Rattus norvegicus	149-152
3607227-4	1987	We then investigate the field strength dependence of the acid-alkaline transition, i.e., the hydrolysis reaction of the water coordinated to the heme iron, in metmyoglobin and methemoglobin.	Water	120-125	hemoglobin subunit gamma 2	Homo sapiens	176-189
2825937-6	1987	The concurrent distribution of specific receptors for both peptides at these sites provides the basis for atrial natriuretic peptide to exert a functional antagonism of the actions of angiotensin II on blood pressure and water and electrolyte homeostasis at multiple sites.	Water	221-226	natriuretic peptide A	Rattus norvegicus	106-132
19848120-1	2009	The effective distribution of affinities (Conditional Affinity Spectrum, CAS) seen by a metal ion binding to a humic substance under natural water conditions is derived and discussed within the NICA-Donnan model.	Water	141-146	BCAR1 scaffold protein, Cas family member	Homo sapiens	73-76
3306623-3	1987	Neuropeptide Y (NPY, 1, 190 pmol) had no significant stimulatory effect on food intake and water consumption in fasted as well as satiated dogs, and actually reduced both food and water intake in insulin-treated dogs.	Water	180-185	neuropeptide Y	Canis lupus familiaris	0-14
3306623-3	1987	Neuropeptide Y (NPY, 1, 190 pmol) had no significant stimulatory effect on food intake and water consumption in fasted as well as satiated dogs, and actually reduced both food and water intake in insulin-treated dogs.	Water	180-185	neuropeptide Y	Canis lupus familiaris	16-19
3606215-1	1987	Tap water consumption was estimated from 3 day weighed dietary records in 102 Canadian preschool children (4-5 yr of age; 58 males, 44 females).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
3494559-2	1987	The ocular changes which characterize the EAU induced by IRBP resemble those seen in rats which develop EAU by immunization with another retinal protein, S-antigen (S-Ag).	Water	42-45	retinol binding protein 3	Rattus norvegicus	57-61
3494559-2	1987	The ocular changes which characterize the EAU induced by IRBP resemble those seen in rats which develop EAU by immunization with another retinal protein, S-antigen (S-Ag).	Water	104-107	retinol binding protein 3	Rattus norvegicus	57-61
3494559-6	1987	In particular, BN rats were more susceptible to IRBP-induced EAU than to the S-Ag-induced disease, while WF and RCS-rdy+ rats developed severe EAU when immunized with S-Ag but showed minimal or no ocular change when immunized with IRBP.	Water	61-64	retinol binding protein 3	Rattus norvegicus	48-52
2955419-2	1987	ICV ANF decreased plasma AVP concentration and increased urinary free water excretion in euhydrated sheep, with excretion of Na and K unaltered.	Water	70-75	natriuretic peptides A	Ovis aries	4-7
19701945-1	2009	Regulation of body water homeostasis occurs by the vasopressin-dependent sorting of aquaporin-2 (AQP2) water channels to and from the apical membrane of renal principal cells.	Water	19-24	aquaporin 2	Homo sapiens	84-95
2951600-0	1987	Atrial natriuretic peptide inhibits angiotensin-stimulated proximal tubular sodium and water reabsorption.	Water	87-92	natriuretic peptide A	Rattus norvegicus	0-26
2951600-7	1987	Thus at physiological concentrations ANP acts within the kidney to decrease proximal reabsorption by inhibition of angiotensin-stimulated sodium and water transport.	Water	149-154	natriuretic peptide A	Rattus norvegicus	37-40
19701945-1	2009	Regulation of body water homeostasis occurs by the vasopressin-dependent sorting of aquaporin-2 (AQP2) water channels to and from the apical membrane of renal principal cells.	Water	19-24	aquaporin 2	Homo sapiens	97-101
3299912-1	1987	We describe the bulk purification of a water-soluble form of RT1-A class I MHC antigens from aqueous extracts of DA liver.	Water	39-44	RT1 class I, locus A	Rattus norvegicus	61-66
19701945-1	2009	Regulation of body water homeostasis occurs by the vasopressin-dependent sorting of aquaporin-2 (AQP2) water channels to and from the apical membrane of renal principal cells.	Water	103-108	aquaporin 2	Homo sapiens	84-95
3299912-2	1987	Using a combination of monoclonal antibody affinity, lentil lectin affinity, and gel permeation chromatography, we were able to obtain large quantities of pure water-soluble RT1-A antigens.	Water	160-165	RT1 class I, locus A	Rattus norvegicus	174-179
3299912-4	1987	The water-soluble RT1-A molecule had a discrete heavy chain of 40 kD, linked noncovalently to beta 2 microglobulin.	Water	4-9	RT1 class I, locus A	Rattus norvegicus	18-23
3296767-1	1987	The Blairex Water Purifier (previously called The Blairex Deionizer) is a filtration unit designed to purify tap water for uses that require distilled or deionized water.	Water	12-17	nuclear RNA export factor 1	Homo sapiens	109-112
3296767-1	1987	The Blairex Water Purifier (previously called The Blairex Deionizer) is a filtration unit designed to purify tap water for uses that require distilled or deionized water.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
3299912-5	1987	The heavy chain of the water-soluble RT1-A molecule was 5 kD smaller than the membrane-bound form of RT1-A from DA liver membranes.	Water	23-28	RT1 class I, locus A	Rattus norvegicus	37-42
19701945-1	2009	Regulation of body water homeostasis occurs by the vasopressin-dependent sorting of aquaporin-2 (AQP2) water channels to and from the apical membrane of renal principal cells.	Water	103-108	aquaporin 2	Homo sapiens	97-101
3299912-7	1987	Large quantities of this water-soluble RT1-A class I antigen from the DA strain, given intravenously to PVG recipients of DA cardiac allografts by a variety of protocols, did not have any effect on graft survival.	Water	25-30	RT1 class I, locus A	Rattus norvegicus	39-44
19619514-1	2009	Aquaporin-3 (AQP3) is a water/glycerol-transporting protein that is strongly expressed at the plasma membranes of keratinocytes in skin.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
2956906-9	1987	Moreover, these results, in combination with a growing body of physiological data, lend support to the hypothesized role of ANF in the regulation of water-electrolyte balance, which may play an important role in cardiovascular pathophysiological states related to hypertension.	Water	149-154	natriuretic peptide A	Rattus norvegicus	124-127
3109156-1	1987	Water conducting systems in hospitals (endoscopes, nebulizers, tap water systems, dental units etc.)	Water	0-5	nuclear RNA export factor 1	Homo sapiens	63-66
19619514-1	2009	Aquaporin-3 (AQP3) is a water/glycerol-transporting protein that is strongly expressed at the plasma membranes of keratinocytes in skin.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
3805723-4	1987	We established that lymphocytes from IRBP immunized donor rats were capable of transferring EAU after in vitro stimulation with either IRBP (lymph node or spleen cells) or concanavalin A (spleen cells only).	Water	92-95	retinol binding protein 3	Rattus norvegicus	135-139
3606810-0	1987	Effect of variation of the composition of CSF in the rat upon drinking of water and hypertonic NaCl solutions.	Water	74-79	colony stimulating factor 2	Rattus norvegicus	42-45
19619514-2	2009	There is evidence for involvement of AQP3-facilitated water and glycerol transport in skin hydration and wound repair, respectively.	Water	54-59	aquaporin 3 (Gill blood group)	Homo sapiens	37-41
3606810-2	1987	Although the infusates were nearly equiosmotic, water drinking during the 0.5 M NaCl-CSF was greater than during 0.7 M sucrose-CSF.	Water	48-53	colony stimulating factor 2	Rattus norvegicus	85-88
3606810-6	1987	In contrast, CSF [Na] was increased by 4-hr IVT infusion of 0.5 M NaCl in rats denied access to water during the infusion.	Water	96-101	colony stimulating factor 2	Rattus norvegicus	13-16
19756144-2	2009	Previous studies of this yeast indicated that the Tsa1 peroxiredoxin is required for optimal growth in low zinc because of its role in degrading H(2)O(2).	Water	145-150	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	50-54
3598910-10	1987	The apparent volume of distribution of unbound drug, steady state, VUss, decreased from 12.4 to 7.7 liters/kg, and the red blood cell/plasma water concentration ratio decreased from 9.2 to 4.0 after administration of AAG.	Water	141-146	orosomucoid 1	Rattus norvegicus	217-220
3025291-5	1987	These results suggest that, in rats, the renal medulla may participate in the natriuresis and diuresis produced by ANF through vascular and tubular effects; the former by changing medullary blood flow at the level of descending vasa recta and the latter by acting on electrolyte and water transport at the level of collecting ducts.	Water	283-288	natriuretic peptide A	Rattus norvegicus	115-118
19927803-1	2009	Scanning electron microscope, atomic force microscope and confocal laser scanning microscope were used to observe the microbial distribution and biofilm structure on the surface of stainless steel plugs and the wall of PPR pipe in the water distribution system.	Water	235-240	PPR1	Homo sapiens	219-222
3310983-7	1987	PMC was also present in both the 100,000 g parotid-tissue supernatant and the water-extract of the ParB granules.	Water	78-83	pseudoautosomal region boundary	Mus musculus	99-103
3607460-4	1987	infusion of iso-osmotic 0.27 M mannitol-CSF more than halved the amount of water normally drunk by dehydrated rats during the fluid access period.	Water	75-80	colony stimulating factor 2	Rattus norvegicus	40-43
3607460-9	1987	A reduction of CSF [Na] will inhibit dehydration induced water drinking provided the osmotic pressure of the CSF is not greatly elevated.	Water	57-62	colony stimulating factor 2	Rattus norvegicus	15-18
3606215-3	1987	Median consumption of tap water consumed alone and tapwater alone plus that used in beverages (ml per day) was 36.5 (range 0-791) and 171.5 (range 0-1036), respectively.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
3606215-7	1987	Hard tap water provided less than 8% of the Canadian Recommended Nutrient Intake (RNI) for magnesium, less than 3% for calcium, and less than 1% for zinc.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	5-8
3600252-2	1987	Spin-echo methods have been used to effect solvent suppression during the collection of 400 and 500 MHz 1H NMR spectra of urine samples containing urea in the concentration range 0.7-1.2 M. There was a marked trough of water Tobs2 values in the pH range 2.6 to 4.1, due to acid-catalyzed proton exchange between urea and the solvent water.	Water	219-224	spindlin 1	Homo sapiens	0-4
3023038-1	1987	Binding sites for rat atrial natriuretic peptide (99-126) were localized and quantified in the subfornical organ and choroid plexus of control and water-deprived rats.	Water	147-152	natriuretic peptide A	Rattus norvegicus	22-48
19570884-2	2009	AVP induces antidiuresis by insertion of aquaporin-2 (AQP2) water channels into the plasma membrane of collecting duct principal cells.	Water	60-65	aquaporin 2	Homo sapiens	41-52
3503486-4	1987	Since presently the only known function of catalase is the enzymatic degradation of hydrogen peroxide to water and oxygen, the simplest interpretation of the ability of catalase to support neuronal survival would be that catalase removes from the culture medium hydrogen peroxide.	Water	105-110	catalase	Gallus gallus	43-51
3503486-4	1987	Since presently the only known function of catalase is the enzymatic degradation of hydrogen peroxide to water and oxygen, the simplest interpretation of the ability of catalase to support neuronal survival would be that catalase removes from the culture medium hydrogen peroxide.	Water	105-110	catalase	Gallus gallus	169-177
3503486-4	1987	Since presently the only known function of catalase is the enzymatic degradation of hydrogen peroxide to water and oxygen, the simplest interpretation of the ability of catalase to support neuronal survival would be that catalase removes from the culture medium hydrogen peroxide.	Water	105-110	catalase	Gallus gallus	169-177
3600252-6	1987	Using the Carr-Purcell-Meiboom-Gill spin-echo pulse sequence, water signals broader than 13 Hz were attenuated by factors of greater than 10(3), and factors of greater than 10(4) were possible with water linewidths greater than 20 Hz, thus allowing the signals from metabolites in the sample to be efficiently digitized.	Water	62-67	spindlin 1	Homo sapiens	36-40
19570884-2	2009	AVP induces antidiuresis by insertion of aquaporin-2 (AQP2) water channels into the plasma membrane of collecting duct principal cells.	Water	60-65	aquaporin 2	Homo sapiens	54-58
19684221-7	2009	Eel AQP3 is dramatically inhibited by extracellular acidity (91% and 69% inhibition of water and glycerol transport respectively at pH 6.5) consistent with channel gating by protons.	Water	87-92	aquaporin 3 (Gill blood group)	Homo sapiens	4-8
3603728-1	1987	A commercial preparation of water-soluble acetylcholinesterase from horse red cells has been purified to a specific activity of 2380 U/mg of protein (a 1660-fold purification) by a twofold affinity chromatography on the known sorbent of Sepharose-p-[NH-(CH2)5-C(O)NH(CH2)5C(O)NH-]-C6H4-N+(CH3)3 X Br- at pH 7.5.	Water	28-33	acetylcholinesterase	Equus caballus	42-62
3108510-4	1987	Physiological studies show that oxytocin, a synthetic analog of antidiuretic hormone, is still capable of inducing increases in water transport in epithelia which were osmotically reversed.	Water	128-133	oxytocin/neurophysin I prepropeptide	Homo sapiens	32-40
3577584-5	1987	After 24 h water deprivation there was a significant increase in plasma AVP levels but no changes in oxytocin or cortisol concentrations.	Water	11-16	vasopressin-neurophysin 2-copeptin	Ovis aries	72-75
19684221-8	2009	Maximal water flux of eel AQP3 occurred around pH 8.2 - close to the physiological pH of plasma in the eel.	Water	8-13	aquaporin 3 (Gill blood group)	Homo sapiens	26-30
3441015-8	1987	Cool tap water immersion initially provided more relief while vegetable oil provided better long-term relief from the pain of "chile burns".	Water	9-14	nuclear RNA export factor 1	Homo sapiens	5-8
18716315-1	2009	Glycosphingolipid (GSL) fatty acid strictly regulates verotoxin 1 (VT1) and the HIV adhesin, gp120 binding to globotriaosyl ceramide within Gb(3)/cholesterol detergent resistant membrane (DRM) vesicle constructs and in Gb(3) water-air interface monolayers in a similar manner.	Water	225-230	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	93-98
3569605-1	1987	A possible involvement of oxytocin (OT) has been indicated in regulation of water and electrolyte metabolism, based on findings that the secretion of OT is increased by either water deprivation or sodium loading.	Water	76-81	oxytocin/neurophysin I prepropeptide	Homo sapiens	26-34
3509190-5	1987	SRB was used in a concentration of 6.25 kg per 1.000 m3 water, to achieve 1.0 ppm Bayluscide concentration according to the producer"s instruction in Massachussett-USA.	Water	56-61	chaperonin containing TCP1 subunit 4	Homo sapiens	0-3
19653224-2	2009	The hot water extract of this herbal mixture gave lipid peroxidation (LPO), cyclo-oxygenase (COX-1 and -2) enzyme and human tumor cell proliferation inhibitory activities between 25 and 250 microg/mL.	Water	8-13	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	93-105
3788570-2	1986	The ability of degrading the intestinal water-soluble mucin was present both in vivo after monocontamination of germ-free rats and in vitro, when adding the microbe to Mucin medium.	Water	40-45	solute carrier family 13 member 2	Rattus norvegicus	54-59
3788570-2	1986	The ability of degrading the intestinal water-soluble mucin was present both in vivo after monocontamination of germ-free rats and in vitro, when adding the microbe to Mucin medium.	Water	40-45	solute carrier family 13 member 2	Rattus norvegicus	168-173
3033696-2	1987	The repeated stress induced a reduction in the maximum number of binding sites (Bmax) for (3H)dihydroalprenolol (DHA) in the cerebral cortex of rats with tap water, without affecting (3H)clonidine binding.	Water	158-163	SEC14-like lipid binding 2	Rattus norvegicus	154-157
19701503-6	2009	Pixel-wise differences as part of PRM(ADC) analysis revealed regions where water mobility increased.	Water	75-80	antizyme inhibitor 2	Homo sapiens	34-42
3028413-0	1987	Spin-trapping of sulfite radical anion, SO3-., by a water-soluble, nitroso-aromatic spin-trap.	Water	52-57	spindlin 1	Homo sapiens	0-4
3028413-0	1987	Spin-trapping of sulfite radical anion, SO3-., by a water-soluble, nitroso-aromatic spin-trap.	Water	52-57	spindlin 1	Homo sapiens	84-88
3786839-7	1986	Neurotensin stimulated, in a dose-related manner, the pancreatic secretion of water, protein and bicarbonate.	Water	78-83	neurotensin	Rattus norvegicus	0-11
19301842-11	2009	This opens new perspectives regarding the PPR chemical modification: between these two characteristic times, we can easily envisage an efficient chemical modification of the PPR molecules in water, as for instance an end-capping reaction leading to the synthesis of polyrotaxanes.	Water	191-196	PPR1	Homo sapiens	42-45
3017421-13	1986	When membranes are prepared in the presence of a water-soluble spin label, TEMPOcholine, ascorbate destroys the signal of untrapped label; when mixed phospholipid-tetracaine are formed by addition of micellar tetracaine, this leads to a complete loss of the ESR signal.	Water	49-54	spindlin 1	Homo sapiens	63-67
3311363-2	1987	This system was firstly validated in a test rig capable of generating pulsatile flow of talc particles in water at physiological velocities and accelerations in a model aorta.	Water	106-111	DIRAS family GTPase 1	Homo sapiens	44-47
2892610-8	1987	Prairie dog plasma insulin values were 69.2, 15.8 and 25.4 microU/ml in fed, and in 24-hr and 32-day food- and water-deprived animals, respectively.	Water	111-116	insulin	Canis lupus familiaris	19-26
3529989-7	1986	Significant and progressive increases in plasma vasopressin concentration and renin activity were observed during water deprivation, but plasma aldosterone did not change from control levels.	Water	114-119	renin	Canis lupus familiaris	78-83
19301842-11	2009	This opens new perspectives regarding the PPR chemical modification: between these two characteristic times, we can easily envisage an efficient chemical modification of the PPR molecules in water, as for instance an end-capping reaction leading to the synthesis of polyrotaxanes.	Water	191-196	PPR1	Homo sapiens	174-177
3530073-3	1986	One to 3 cm H2O of CPAP did not eliminate the cyclic occurrence of obstructive apneas.	Water	12-15	centromere protein J	Homo sapiens	19-23
3530073-5	1986	With 13 to 15 cm H2O CPAP, apneas were eliminated; mean oxygen saturation rose from 84 +/- 6% (mean +/- SD) to 92 +/- 2%, and EMG activity was reduced or eliminated.	Water	17-20	centromere protein J	Homo sapiens	21-25
19515809-1	2009	Proper targeting of the aquaporin-2 (AQP2) water channel to the collecting duct apical plasma membrane is critical for the urine concentrating mechanism and body water homeostasis.	Water	43-48	aquaporin 2	Canis lupus familiaris	24-35
3779043-1	1986	The water soluble A subunit of the human TSH receptor has been shown to have an isoelectric point of 5.	Water	4-9	thyroid stimulating hormone receptor	Homo sapiens	41-53
3653460-0	1987	Long-term efficacy and side effects of tap water iontophoresis of palmoplantar hyperhidrosis--the usefulness of home therapy.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
19515809-1	2009	Proper targeting of the aquaporin-2 (AQP2) water channel to the collecting duct apical plasma membrane is critical for the urine concentrating mechanism and body water homeostasis.	Water	43-48	aquaporin 2	Canis lupus familiaris	37-41
19515809-1	2009	Proper targeting of the aquaporin-2 (AQP2) water channel to the collecting duct apical plasma membrane is critical for the urine concentrating mechanism and body water homeostasis.	Water	162-167	aquaporin 2	Canis lupus familiaris	24-35
2941271-2	1986	The effect of ANF on vasopressin secretion was greater in the water-deprived animal.	Water	62-67	natriuretic peptide A	Rattus norvegicus	14-17
19515809-1	2009	Proper targeting of the aquaporin-2 (AQP2) water channel to the collecting duct apical plasma membrane is critical for the urine concentrating mechanism and body water homeostasis.	Water	162-167	aquaporin 2	Canis lupus familiaris	37-41
3666400-7	1987	After oral or intraduodenal administration of 3 g/kg of HO1 or HO2, gastric juice secretion and ulcers induced by water immersion stress, histamine and reserpine in rats were inhibited.	Water	114-119	heme oxygenase 1	Rattus norvegicus	56-59
19645015-6	2009	A total of 0.5-5 mM of H(2)O(2) but not lower concentrations (5-200 microM) of H(2)O(2) inhibited mTOR signaling, as manifested by dephosphorylation of S6K (T389), 4E-BP1 (T37/46), and S6(S235/236) in MC3T3-E1 and MG63 cells.	Water	23-28	mechanistic target of rapamycin kinase	Mus musculus	98-102
3817909-0	1987	Water-soluble form of RT1.A class I MHC molecules in the kidney and liver of the rat.	Water	0-5	RT1 class I, locus A	Rattus norvegicus	22-27
3817909-2	1987	In this report, we demonstrate that liver and kidney in the DA rat strain contain large amounts of a water-soluble RT1.A class I molecule with a discrete heavy chain approximately 5 kd smaller than the membrane-bound form.	Water	101-106	RT1 class I, locus A	Rattus norvegicus	115-120
2941632-1	1986	Atrial natriuretic factor (ANF) increases sodium (Na+) and water excretion 8-10 fold on repeated administration to anesthetized rats.	Water	59-64	natriuretic peptide A	Rattus norvegicus	0-25
2941632-1	1986	Atrial natriuretic factor (ANF) increases sodium (Na+) and water excretion 8-10 fold on repeated administration to anesthetized rats.	Water	59-64	natriuretic peptide A	Rattus norvegicus	27-30
2941632-5	1986	These findings suggest that ANF exerts its effects on renal Na+ and water handling via a dopaminergic mechanism; however, changes in intrarenal hemodynamics secondary to dopamine receptor blockade may attenuate the actions of ANF.	Water	68-73	natriuretic peptide A	Rattus norvegicus	28-31
2941703-4	1986	The dehydration-induced decrease in plasma IR-ANF and its very low secretion after restoring drinking may be essential for the homeostasis of water conservation in both DI and LE rats.	Water	142-147	natriuretic peptide A	Rattus norvegicus	46-49
3817909-6	1987	The half-life of the class I molecule in serum was measured to be approximately 1.5 h. The LEW rat strain produced detectable but substantially smaller amounts of water-soluble RT1.A molecules.	Water	163-168	RT1 class I, locus A	Rattus norvegicus	177-182
3817909-7	1987	Our studies indicate that RT1.A class I MHC antigens are synthesized and presumably secreted in a smaller water-soluble form by liver, kidney, and possibly other tissues under physiological conditions, a point of considerable interest in view of the immunoregulatory functions of the membrane-bound forms of these molecules.	Water	106-111	RT1 class I, locus A	Rattus norvegicus	26-31
19645015-6	2009	A total of 0.5-5 mM of H(2)O(2) but not lower concentrations (5-200 microM) of H(2)O(2) inhibited mTOR signaling, as manifested by dephosphorylation of S6K (T389), 4E-BP1 (T37/46), and S6(S235/236) in MC3T3-E1 and MG63 cells.	Water	23-28	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	164-170
19661343-0	2009	Elevated ERCC1 gene expression in blood cells associated with exposure to arsenic from drinking water in Inner Mongolia.	Water	96-101	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	9-14
3431351-0	1987	Spin-lattice relaxation times of bound water--its determination and implications for tissue discrimination.	Water	39-44	spindlin 1	Homo sapiens	0-4
2428696-2	1986	Water molecules are presented in the ST2 model.	Water	0-5	ST2	Homo sapiens	37-40
19661343-5	2009	RESULTS: The mRNA levels of ERCC1 expression were positively associated with water arsenic concentration (slope=0.313, p=0.0043) and nail arsenic concentration (slope=0.474, p=0.0073).	Water	77-82	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	28-33
19499332-7	2009	And these metabolites are responsible for separation of the data along PC1 and PC2 which may be used as biomarkers to indicate the source water pollution.	Water	138-143	minisatellite 6 hypermutable 3	Mus musculus	79-82
3459148-3	1986	The spectrum of bound Mel is obtained directly from the spectrum of the [2H]CaM X Mel complex and is found to resemble strongly the spectrum of the helical species in methanol rather than that of the random coil species in water.	Water	223-228	calmodulin 2	Gallus gallus	76-79
3556409-3	1986	These results suggest a possible regulatory role of CCK in water metabolism and release of neurohypophysial hormones.	Water	59-64	cholecystokinin	Rattus norvegicus	52-55
2946239-2	1986	Intra-aortic infusions of synthetic ANF (28 amino acids) at 7.5 and 15 micrograms X kg-1 X h-1 produced dose-related increases in absolute and fractional sodium and water excretion under steady-state conditions; renal blood flow (RBF) was unchanged, whereas mean arterial pressure significantly decreased but remained within the autoregulatory range.	Water	165-170	natriuretic peptide A	Rattus norvegicus	36-39
2870921-4	1986	With highly purified preparations of methylmalonyl-CoA mutase, effective tritium exchange from [5"-3H]adenosylcobalamin to water required the addition of methylmalonyl-CoA epimerase and of substrate (e.g. succinyl-CoA).	Water	123-128	methylmalonyl-CoA mutase	Homo sapiens	37-61
3790504-2	1986	Analysis of products formed from incubation of dopamine with PAO in tritiated water indicates a stereospecific, pro-R, incorporation of label at C-2.	Water	78-83	complement C2	Bos taurus	145-148
19367412-8	2009	Furthermore, adult CD-1 kidneys expressed more AQP2 in the collecting ducts, which was reflected by a significant delay in excreting a water load.	Water	135-140	aquaporin 2	Mus musculus	47-51
3697522-0	1986	Chloroform in tap water and human blood.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
19587238-1	2009	Binding of the peptide hormone vasopressin to its type-2 receptor (V2R) in kidney triggers a cAMP-mediated translocation of Aquaporin-2 water channels to the apical membrane, resulting in water reabsorption and thereby preventing dehydration.	Water	136-141	aquaporin 2	Homo sapiens	124-135
2942846-2	1986	The ICV injection of ANF attenuated water intake induced by AII or 48-hr water deprivation.	Water	36-41	natriuretic peptide A	Rattus norvegicus	21-24
2942846-2	1986	The ICV injection of ANF attenuated water intake induced by AII or 48-hr water deprivation.	Water	73-78	natriuretic peptide A	Rattus norvegicus	21-24
2942846-5	1986	These results suggested that ANF in the brain is involved in the central control of water intake.	Water	84-89	natriuretic peptide A	Rattus norvegicus	29-32
2945441-5	1986	After rehydration, IR-ANF was elevated dramatically within 3 min and gradually for up to 1 h after water was offered; AVP decreased within 3 min of rehydration and stayed at the water-repleted level during the next 1 h. Na+, osm, and Hct did not change until 15, 9, and 30 min after rehydration, respectively.	Water	99-104	natriuretic peptide A	Rattus norvegicus	22-25
2945441-5	1986	After rehydration, IR-ANF was elevated dramatically within 3 min and gradually for up to 1 h after water was offered; AVP decreased within 3 min of rehydration and stayed at the water-repleted level during the next 1 h. Na+, osm, and Hct did not change until 15, 9, and 30 min after rehydration, respectively.	Water	178-183	natriuretic peptide A	Rattus norvegicus	22-25
19587238-1	2009	Binding of the peptide hormone vasopressin to its type-2 receptor (V2R) in kidney triggers a cAMP-mediated translocation of Aquaporin-2 water channels to the apical membrane, resulting in water reabsorption and thereby preventing dehydration.	Water	188-193	aquaporin 2	Homo sapiens	124-135
19462976-3	2009	We found that Prx 3 displayed strong reactivity with H(2)O(2), with a competitive kinetic approach generating a second order rate constant of 2 x 10(7) M(-1) s(-1).	Water	53-58	periaxin	Homo sapiens	14-17
3467419-1	1986	The present study was undertaken in a community, where the tap water has been optimally fluoridated since 1959 (1.0-1.2 ppm).	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
3737446-6	1986	A similar decrease of about 60% in POMC mRNA levels in the NIL was seen when EOS was given in the drinking water (5 mg/ml).	Water	107-112	proopiomelanocortin	Rattus norvegicus	35-39
19607658-2	2009	There are 13 known mammalian aquaporins (AQP0 to AQP12), some of which have been shown to have unexpected cellular roles beyond transmembrane water transport.	Water	142-147	aquaporin 12A	Homo sapiens	49-54
2424148-8	1986	Wash in running tap water for 1 hr.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
3544726-0	1986	Importance of circulating and urinary tissue kallikrein in the control of acute natriuresis and diuresis evoked by water immersion in man.	Water	115-120	kallikrein related peptidase 4	Homo sapiens	45-55
3570320-0	1986	Use of tap water instead of electrode jelly for recording electrocardiograms.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
19566090-1	2009	Two water-soluble "through-bond energy transfer cassettes" (TBET-cassettes) were prepared.	Water	4-9	T-box transcription factor 21	Homo sapiens	60-64
3720354-2	1986	Provocative testing with tap water produced transient edema and pruritus.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
3720354-4	1986	After several weeks, the angioedema gradually subsided, the reaction to tap water became negative, and the patient was able to swim again without reactions.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
3090573-2	1986	IVT infusions of isotonic artificial CSF (art-CSF) solutions at 10 and 38 microliters/hr increased mean CSFP from control preinfusion level of 3.6 cm H2O to 4.6 cm H20 (n.s.)	Water	150-153	colony stimulating factor 2	Rattus norvegicus	37-40
3090573-2	1986	IVT infusions of isotonic artificial CSF (art-CSF) solutions at 10 and 38 microliters/hr increased mean CSFP from control preinfusion level of 3.6 cm H2O to 4.6 cm H20 (n.s.)	Water	150-153	colony stimulating factor 2	Rattus norvegicus	46-49
3090573-4	1986	IVT infusion of hyperosmolar art CSF solutions (saccharide and salt solutions of approximate 1000 mOsm/kg) at 38 microliters/hr resulted in a larger increase of CSFP which equilibrated at 8.5 cm H2O (p less than 0.001) after 90 min of infusion.	Water	195-198	colony stimulating factor 2	Rattus norvegicus	33-36
19566644-4	2009	Pretreatments with different protein kinase inhibitors also reduced the water stress-induced H2O2 production and the water stress-enhanced activities of antioxidant enzymes such as superoxide dismutase, catalase, ascorbate peroxidase and glutathione reductase.	Water	117-122	glutathione reductase 1	Zea mays	238-259
3735419-2	1986	An analysis of the Rick procedure for quantifying this water content (Dorge et al., 1978; Rick et al., 1979) reveals a hidden assumption; namely, that the sample and standard densities, in the hydrated state, must be equal.	Water	55-60	receptor interacting serine/threonine kinase 2	Homo sapiens	19-23
3735419-2	1986	An analysis of the Rick procedure for quantifying this water content (Dorge et al., 1978; Rick et al., 1979) reveals a hidden assumption; namely, that the sample and standard densities, in the hydrated state, must be equal.	Water	55-60	receptor interacting serine/threonine kinase 2	Homo sapiens	90-94
3735419-5	1986	These equations show that errors in using the Rick technique for measuring water content should be small, a few per cent, unless the sample contains a very heterogeneous distribution of mass or the water content of the standard is a poor representation of the sample.	Water	75-80	receptor interacting serine/threonine kinase 2	Homo sapiens	46-50
2998690-5	1985	Our data suggest that acute infusion of ANF reveals a defect of sodium and water handling in SHR.	Water	75-80	natriuretic peptide A	Rattus norvegicus	40-43
19358593-7	2009	Water contact angle measurements indicated that the films fabricated by the samples obtained under the different ratios of PEG-6000/ODA could exhibit tunable wettability ranging from superhydrophilicity to superhydrophobicity.	Water	0-5	progestagen associated endometrial protein	Homo sapiens	123-126
19268466-2	2009	The expression and immunolocalization of two water channels, AQP1 and AQP4, in the rat retina during experimental high salt loading were investigated in this study.	Water	45-50	aquaporin 4	Rattus norvegicus	70-74
3910918-1	1985	The kallikrein-kininogen-kinin system has been postulated to play a role in the regulation of blood pressure and modulation of renal salt and water transport.	Water	142-147	kallikrein related peptidase 4	Homo sapiens	4-14
2939242-1	1986	An analysis of the inhibition constants of pyrazoles, phenylacetamides, formylbenzylamines, and acetamides acting on liver alcohol dehydrogenase (ADH) yields quantitative structure-activity relationships (QSAR) having a linear dependency on octanol-water partition coefficients (log P).	Water	249-254	aldo-keto reductase family 1 member A1	Homo sapiens	123-144
2939242-1	1986	An analysis of the inhibition constants of pyrazoles, phenylacetamides, formylbenzylamines, and acetamides acting on liver alcohol dehydrogenase (ADH) yields quantitative structure-activity relationships (QSAR) having a linear dependency on octanol-water partition coefficients (log P).	Water	249-254	aldo-keto reductase family 1 member A1	Homo sapiens	146-149
2939242-4	1986	Study of a molecular graphics model of ADH constructed from the X-ray crystallographic coordinates shows that the substituents are engulfed in a long hydrophobic channel which is so narrow that water of solvation must be removed from them in the binding process.	Water	194-199	aldo-keto reductase family 1 member A1	Homo sapiens	39-42
2934063-7	1985	The results of this study provide evidence indicating that endogenous atrial natriuretic factor plays an important role in the regulation of urinary water and sodium excretion and plasma renin activity.	Water	149-154	natriuretic peptide A	Rattus norvegicus	70-95
19348936-6	2009	In the presence of H(2)O(2), SHP-2 formed a complex with STAT-3 and reduced the steady-state STAT-3 phosphorylation level.	Water	19-24	signal transducer and activator of transcription 3	Rattus norvegicus	57-63
3931454-2	1985	Pseudomonas aeruginosa, serotype 0:4, was isolated from a patient and the whirlpool-spa water.	Water	88-93	surfactant protein A2	Homo sapiens	84-87
2936598-2	1986	Recently, ANF-like immunoreactivity has been detected in the hypothalamus of the rat, and central administration of ANF has been shown to block dehydration-induced water intake.	Water	164-169	natriuretic peptide A	Rattus norvegicus	116-119
19348936-6	2009	In the presence of H(2)O(2), SHP-2 formed a complex with STAT-3 and reduced the steady-state STAT-3 phosphorylation level.	Water	19-24	signal transducer and activator of transcription 3	Rattus norvegicus	93-99
19138132-1	2009	The goal of this study was to examine the expression and regulation of aquaporin2 (AQP2), a tonicity-sensitive water channel in nucleus pulposus cells of the intervertebral disc.	Water	111-116	aquaporin 2	Mus musculus	71-81
3634759-2	1986	In our hospital, patients are immersed in a tub of warm, continuously-flowing tap water.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
4076075-4	1985	Both As and Se appear to be mobilized from household plumbing into tap water by the corrosive action of soft, mildly acidic water, while surface water catchment systems in areas impacted by acidic deposition may contain elevated soluble As levels.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
4085589-1	1985	In adults, the inability to secrete ABH blood group substances in water-soluble form has been recognized as an independent risk factor for the development of chronic obstructive lung disease.	Water	66-71	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	36-39
19138132-1	2009	The goal of this study was to examine the expression and regulation of aquaporin2 (AQP2), a tonicity-sensitive water channel in nucleus pulposus cells of the intervertebral disc.	Water	111-116	aquaporin 2	Mus musculus	83-87
3080164-0	1986	Observations on the effects of immersion in Bath spa water.	Water	53-58	surfactant protein A2	Homo sapiens	49-52
19240350-6	2009	MS2 on strawberries was inactivated by 68%, 92% and 96% at free chlorine (FC) concentrations of &lt; or = 2, 20 and 200 ppm in wash water, respectively.	Water	132-137	MS2	Homo sapiens	0-3
3512655-8	1986	The root surface must not be handled, scraped, brushed, or have any part removed; it can be rinsed with sterile water, saline, or tap water but not with caustic solutions, disinfectants, or medicaments to clean the surface.	Water	134-139	nuclear RNA export factor 1	Homo sapiens	130-133
3643724-3	1986	The renal kallikrein regulates the water excretion decreasing the reabsorption of water in the distal nephron.	Water	35-40	kallikrein 1	Rattus norvegicus	4-20
3643724-3	1986	The renal kallikrein regulates the water excretion decreasing the reabsorption of water in the distal nephron.	Water	82-87	kallikrein 1	Rattus norvegicus	4-20
3752932-6	1986	We have shown the influence of the geographical origin of the tap water on the Ca and F intake, as well as the influence of individual behaviour with respect to the selection of his main drink.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
3743230-8	1986	Preliminary analysis of the geographical variation in the Si content of tap water suggests that uraemic hypersilicaemia may protect haemodialysed patients from the development of aluminium dementia.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
3792134-4	1986	The refinement of TnC at 2.2 A resolution highlights the intricate hydrogen-bonded network common to the Ca2+-bound loops and provides an explanation for the presence of a water molecule in the 5th coordination position of the Ca2+ ion.	Water	172-177	tenascin	Meleagris gallopavo	18-21
3743379-1	1986	Antineoplaston A10 (3-phenylacetylamino-2, 6-piperidinedione) has poor solubility in water.	Water	85-90	UDP glucuronosyltransferase 1 family, polypeptide A7C	Mus musculus	15-18
3792293-0	1986	On the molecular mechanism of liver alcohol dehydrogenase: Monte Carlo simulations and X-ray studies of water in the substrate channel.	Water	104-109	aldo-keto reductase family 1 member A1	Homo sapiens	36-57
3792293-1	1986	Water structure in the substrate channel of liver alcohol dehydrogenase as a function of the oxidation state of the coenzyme nicotinamide ring has been studied with Monte Carlo simulations.	Water	0-5	aldo-keto reductase family 1 member A1	Homo sapiens	50-71
3082689-2	1986	Inhibiting the ornithine decarboxylase (ODC) activity DFMO depleted putrescine and spermidine to 30-50 and 50-60%, respectively, and increased spermine to 25-60% compared with the controls, when given as 2% solution in drinking water of the tumor-bearing animals.	Water	228-233	ornithine decarboxylase, structural 1	Mus musculus	15-38
3082689-2	1986	Inhibiting the ornithine decarboxylase (ODC) activity DFMO depleted putrescine and spermidine to 30-50 and 50-60%, respectively, and increased spermine to 25-60% compared with the controls, when given as 2% solution in drinking water of the tumor-bearing animals.	Water	228-233	ornithine decarboxylase, structural 1	Mus musculus	40-43
3553530-1	1986	Bacteria capable of methylating Hg2+ have been isolated from sediment, water, soil and the gastrointestinal tract of humans.	Water	71-76	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	32-35
3805713-8	1986	M. xenopi was found in tap water of 5 persons with M. xenopi in their sputum and in one of the two healthy persons.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
2948065-5	1986	r-AP III caused a slight increase in plasma renin activity from 0.65 +/- 0.46 in controls to 1.02 +/- 0.47 ng X ml-1 X h-1 in water diuretic dogs and from 3.19 +/- 0.51 in controls to 3.72 +/- 0.81 ng X ml-1 X h-1 in hydropenic dogs.	Water	126-131	renin	Canis lupus familiaris	44-49
3936569-0	1985	Observations on the effect of immersion in Bath spa water.	Water	52-57	surfactant protein A2	Homo sapiens	48-51
4074749-3	1985	Substantial cross-linking of adrenodoxin reductase with adrenodoxin was observed when water-soluble carbodiimide was used as cross-linking reagent.	Water	86-91	ferredoxin reductase	Bos taurus	29-50
3934164-8	1985	Proteins A and C together catalyze the reduction of molecular oxygen to water, a reaction prevented by protein B.	Water	72-77	prolyl 3-hydroxylase 3	Homo sapiens	103-112
4092092-0	1985	Phase-structure transitions of the elastin polypentapeptide-water system within the framework of composition-temperature studies.	Water	60-65	elastin	Homo sapiens	35-42
2937944-0	1985	[Chronic effects of synthetic rat atrial natriuretic factor (ANF) on blood pressure and sodium-water excretion in conscious rats].	Water	95-100	natriuretic peptide A	Rattus norvegicus	34-59
4064378-9	1985	Implementation of SST requires precise control of the concentrate and the water, and equipment adapted for accurate, programmable sequential control of Na+Di and ultrafiltration rate.	Water	74-79	somatostatin	Homo sapiens	18-21
4054704-1	1985	Motilin, pancreatic polypeptide and gastrin blood concentrations in response to drinking water have been studied in 40 patients with functional bowel disease and compared with results in two groups of healthy control subjects.	Water	89-94	motilin	Homo sapiens	0-7
2997281-6	1985	The enhanced net water transport induced by AVP in isolated, perfused rabbit cortical collecting tubules also was completely blocked by this AVP analogue.	Water	17-22	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	44-47
2997281-6	1985	The enhanced net water transport induced by AVP in isolated, perfused rabbit cortical collecting tubules also was completely blocked by this AVP analogue.	Water	17-22	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	141-144
3929686-0	1985	NADPH-cytochrome P-450 reductase-cytochrome b5 interactions: crosslinking of the phospholipid vesicle-associated proteins by a water-soluble carbodiimide.	Water	127-132	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	0-32
3929686-0	1985	NADPH-cytochrome P-450 reductase-cytochrome b5 interactions: crosslinking of the phospholipid vesicle-associated proteins by a water-soluble carbodiimide.	Water	127-132	cytochrome b5	Oryctolagus cuniculus	33-46
3842880-4	1985	Over one half of these burns were caused by tap water.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
2865021-1	1985	Intravenous infusion of somatostatin in six water loaded normal human subjects produced a prompt reduction in urine flow accompanied by a rise in urine osmolality and a decrease in free water clearance.	Water	44-49	somatostatin	Homo sapiens	24-36
2865021-1	1985	Intravenous infusion of somatostatin in six water loaded normal human subjects produced a prompt reduction in urine flow accompanied by a rise in urine osmolality and a decrease in free water clearance.	Water	186-191	somatostatin	Homo sapiens	24-36
4026843-1	1985	Circular dichroism (CD) is used to follow the conformational changes that attend temperature dependent aggregation leading to the viscoelastic (coacervate) state of the polypentapeptide of elastin in water.	Water	200-205	elastin	Homo sapiens	189-196
30943617-1	1985	One hundred thirty-two pork carcasses were used with 36 of these receiving a wash with tap water and 96 receiving a wash with tap water plus 200 ppm of sodium hypochlorite.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
3872204-1	1985	The effect of secretin on gastric bleeding induced by water (20 degrees C) immersion stress was studied by means of either perfusion of hydrochloric acid (0.13 N) or instillation of hydrochloric acid solution (0.4 N) into the rat stomach.	Water	54-59	secretin	Rattus norvegicus	14-22
2580366-4	1985	The quality of silver impregnation in methods using tap water in the reducing solutions varies in different laboratories.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
3015305-2	1985	Pentavalent antimony on the serosal surface significantly inhibited oxytocin-induced water flow but when the drug was added to the mucosal surface only the effect of low oxytocin concentrations was reduced.	Water	85-90	oxytocin/neurophysin I prepropeptide	Homo sapiens	68-76
3015305-5	1985	It is suggested that phosphodiesterase activation might play a role in the mechanism of pentavalent antimonial inhibition of oxytocin-induced water flow in the isolated toad bladder.	Water	142-147	oxytocin/neurophysin I prepropeptide	Homo sapiens	125-133
3161851-6	1985	These results indicate that ANF may have important hemodynamic effects in kidney, lung, liver and adrenal cortex, may regulate water and ion transport in small intestine and ciliary bodies and may have metabolic effects in the liver.	Water	127-132	natriuretic peptide A	Rattus norvegicus	28-31
3872839-2	1985	Athymic nude rats (rnu/rnu) have been previously shown to be refractory to EAU induction and antibody production to S-antigen, while heterozygous (rnu/+) are good responders.	Water	75-78	forkhead box N1	Rattus norvegicus	19-22
3887117-5	1985	The plasma renin activity increased with hypercapnic acidosis in both water loaded and euvolemic dogs.	Water	70-75	renin	Canis lupus familiaris	11-16
3844632-3	1985	The increased kallikrein excretion in nephrotic syndrome was not explained by leakage from plasma, protein binding of active kallikrein, passive "washout" due to changes in sodium and water excretion, or by increased activity of the renin-angiotensin-aldosterone system, but may relate to changes in extracellular volume, plasma oncotic pressure and volume, or other intrarenal haemodynamic or hormonal factors.	Water	184-189	kallikrein related peptidase 4	Homo sapiens	14-24
3966240-1	1985	In rat skeletal muscle, chronic exposure to 50 ppm Cd2+ in drinking water produced both ultrastructural and functional damage, which took place successively and increased gradually with duration of treatment.	Water	68-73	Cd2 molecule	Rattus norvegicus	51-54
6095635-1	1984	Oat or bean products, rich in water-soluble fiber, have distinct hypocholesterolemic effects in humans.	Water	30-35	brain expressed associated with NEDD4 1	Homo sapiens	7-11
16663862-5	1984	On the basis of the sensitivity of the lipoxygenase reaction to both inhibitors (about 90%), the first burst is tentatively assigned to oxy-radicals mobilized upon water uptake by the embryonic axes, and the second phase is tentatively identified as due to lipoxygenase activity.	Water	164-169	linoleate 9S-lipoxygenase-4	Glycine max	39-51
6438052-2	1984	Aflatoxins B1, B2, G1, and G2 were extracted from 50 g sample with 200 mL methanol-water (85 + 15).	Water	83-88	anthocyanin regulatory R-S protein-like	Zea mays	11-29
6485430-1	1984	Pancreatic lipase (triacylglycerol-acylhydrolase EC 3.1.1.3) hydrolyzes triglycerides on the lipid-water-boundary surfaces of micelles.	Water	99-104	pancreatic lipase	Homo sapiens	0-17
6741939-6	1984	Over a 12-month period in which the tap water aluminum content averaged over 10 mumol/L (270 micrograms/L), the product water had an aluminum content consistently under 2 mumol/L, being under 1 mumol/L (27 micrograms/L) on 19 out of 20 occasions.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
6205334-5	1984	Solutions of lactose, fructose, glucose and galactose were preferred to plain tap water.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
6610676-5	1984	The circular dichroism spectra of synthetic peptides corresponding to sequences 57-77, 65-77, and 73-77 in human C3a were measured in water and trifluoroethanol.	Water	134-139	complement C3	Homo sapiens	113-116
6736012-2	1984	The deuterium isotope effect on the reciprocal lifetime (tau-1) of excited Eu(III) in human Factor Xa has indicated that 2 to 3 water molecules remain on Eu(III) after being complexed by Factor Xa, suggesting that 3-6 ligand atoms are provided by the protein, probably through two or three gamma-carboxyglutamic acids (GLA).	Water	128-133	coagulation factor X	Homo sapiens	92-101
19240350-7	2009	MS2 was detected in wash water containing &lt; or = 2 ppm FC in one trial, but was not detected in water containing 20 or 200 ppm FC.	Water	25-30	MS2	Homo sapiens	0-3
6594871-1	1984	Emptying of the human gall-bladder has previously been shown to be associated with the release of motilin, both in the fasting state and after various stimuli, such as oral intake of fat or water.	Water	190-195	motilin	Homo sapiens	98-105
19240350-8	2009	The presence and absence of MS2 in wash water containing various levels of FC highlight the importance of controlling sanitizer levels to prevent viral cross contamination of strawberries.	Water	40-45	MS2	Homo sapiens	28-31
6393721-7	1984	Extracellular water (ECW) increased significantly as judged from ECW/BCM calculations.	Water	14-19	TNF receptor superfamily member 17	Homo sapiens	69-72
19420711-3	2009	In addition, the supply of a 0.01% solution of the extract as drinking water prevented the elevation of the plasma glucose level and intestinal alpha-glucosidase activities in type 1 diabetic mice.	Water	71-76	sucrase isomaltase (alpha-glucosidase)	Mus musculus	144-161
19011940-2	2009	within a few hundred meters downstream of the discharge site of the Westerhofer Bach, a hardwater rivulet, raised the question whether adjacent soil may serve as a reservoir of bacteria not detected in discharge water.	Water	92-97	acyl-CoA thioesterase 7	Homo sapiens	80-84
19138757-4	2009	A control group was exposed to tap water (pH 8.0; 26 degrees C; 7.20 mg O(2)/L).	Water	35-40	transporter associated with antigen processing, subunit type c	Danio rerio	31-34
19534119-0	2009	LFERs for soil organic carbon-water distribution coefficients (Koc) at environmentally relevant sorbate concentrations.	Water	30-35	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	63-66
19368448-4	2009	The potential energy barrier at the MP2/6-311++(3df,3pd)//MP2/6-31G(d,p) level was 4.8 kcal/mol for the triple proton transfer involving two water molecules with a rate constant of 1.6x10(3) s(-1) at 197 K. The potential energy curve near the saddle points was very flat and the tunneling effect on the proton transfer was negligible.	Water	141-146	tryptase pseudogene 1	Homo sapiens	36-39
19211910-6	2009	AQP2 is an essential component of the urine concentration mechanism whose controlled expression dictates apical water permeability of collecting duct principal cells.	Water	112-117	aquaporin 2	Homo sapiens	0-4
18941904-4	2009	These effects of H(2)O(2) were suppressed by pretreatment of the cells with 1 muM of LaCl(3) for 2 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2, JNK and p38 MAPK, but only the last two were associated with the ALP activity.	Water	17-22	mitogen-activated protein kinase 8	Rattus norvegicus	165-168
4093520-3	1985	The methyl, ethyl, and butyl esters of beta-lactoglobulin showed enhanced surface activity, determined with surface and interfacial tension measurements at an air/water and oil/water interface, respectively.	Water	163-168	beta-lactoglobulin	Bos taurus	39-57
18941904-4	2009	These effects of H(2)O(2) were suppressed by pretreatment of the cells with 1 muM of LaCl(3) for 2 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2, JNK and p38 MAPK, but only the last two were associated with the ALP activity.	Water	115-120	mitogen-activated protein kinase 8	Rattus norvegicus	165-168
4093520-3	1985	The methyl, ethyl, and butyl esters of beta-lactoglobulin showed enhanced surface activity, determined with surface and interfacial tension measurements at an air/water and oil/water interface, respectively.	Water	177-182	beta-lactoglobulin	Bos taurus	39-57
19373578-6	2009	RESULTS: Treatment of EAU with anti-IL-17 antibody delayed the onset of ocular inflammation and markedly inhibited the development of EAU.	Water	22-25	interleukin 17A	Rattus norvegicus	36-41
2856718-2	1985	Kallikrein inhibitors were almost completely removed by dialysis against water, confirming previous reports of their low molecular size.	Water	73-78	kallikrein related peptidase 4	Homo sapiens	0-10
3908086-10	1985	Some domestic tap-water supplies contain aluminum in high concentration, either naturally or because aluminum has been added as a flocculant in the purification process.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
2931997-1	1985	It is known that atrial extracts (AE) and synthetic atrial natriuretic factor (ANF) can increase glomerular filtration rate (GFR) and electrolyte and water excretion both in vivo and in vitro.	Water	150-155	natriuretic peptide A	Rattus norvegicus	52-77
2931997-1	1985	It is known that atrial extracts (AE) and synthetic atrial natriuretic factor (ANF) can increase glomerular filtration rate (GFR) and electrolyte and water excretion both in vivo and in vitro.	Water	150-155	natriuretic peptide A	Rattus norvegicus	79-82
2931997-4	1985	Extracts of atrial tissue (1 mg/ml) and high concentrations of ANF (31 and 61 ng/ml) significantly increased both GFR and electrolyte and water excretion.	Water	138-143	natriuretic peptide A	Rattus norvegicus	63-66
2931997-5	1985	During continued infusion of ANF, GFR stabilized at increased levels, but sodium and water excretion continued to increase.	Water	85-90	natriuretic peptide A	Rattus norvegicus	29-32
2931997-7	1985	Infusion of a low concentration of ANF (3 ng/ml) significantly increased sodium and water excretion without changing either GFR or potassium excretion.	Water	84-89	natriuretic peptide A	Rattus norvegicus	35-38
2932778-4	1985	This high affinity ANP receptor site in renal cortex membrane indicated that ANP controlled the balance of water and sodium excretion due to this receptor site in the kidney.	Water	107-112	natriuretic peptide A	Rattus norvegicus	19-22
2932778-4	1985	This high affinity ANP receptor site in renal cortex membrane indicated that ANP controlled the balance of water and sodium excretion due to this receptor site in the kidney.	Water	107-112	natriuretic peptide A	Rattus norvegicus	77-80
4035297-1	1985	A drink of water was found to cause partial emptying of the human gallbladder in parallel with the release of motilin.	Water	11-16	motilin	Homo sapiens	110-117
4004231-9	1985	In addition, the quality of swimming pool water also depends on the quality of its source tap water.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	90-93
4004231-9	1985	In addition, the quality of swimming pool water also depends on the quality of its source tap water.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
4004238-3	1985	In brief, a 100- to 1,000-ml sample of tap water is drawn through a large surface, customized filter housed in the device, and bacteria, rust, and humic acid in the water are concentrated thereon.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
3995774-2	1985	The aluminium content found for tap water was 6-36 micrograms/l.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
3995409-5	1985	Drinking water from the tap was tested in parallel with lake water, and its mutagenicity tended to fluctuate with the mutagenicity of the lake water.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	24-27
3995409-5	1985	Drinking water from the tap was tested in parallel with lake water, and its mutagenicity tended to fluctuate with the mutagenicity of the lake water.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	24-27
3846709-5	1985	Inhibition of kallikrein by aprotinin caused vasopressin-stimulated water flow to increase further (24.8 +/- 4.9 to 34.5 +/- 4.8 microliters/min) while potentiation of kinins by captropril caused vasopressin-stimulated water flow to decrease (45 +/- 6.3 to 30.5 +/- 5.4 microliters/min).	Water	68-73	kallikrein related peptidase 4	Homo sapiens	14-24
3846709-5	1985	Inhibition of kallikrein by aprotinin caused vasopressin-stimulated water flow to increase further (24.8 +/- 4.9 to 34.5 +/- 4.8 microliters/min) while potentiation of kinins by captropril caused vasopressin-stimulated water flow to decrease (45 +/- 6.3 to 30.5 +/- 5.4 microliters/min).	Water	219-224	kallikrein related peptidase 4	Homo sapiens	14-24
4038942-0	1985	Neurotensin diminishes grooming and stimulates paper shredding behavior induced by water immersion of rats.	Water	83-88	neurotensin	Rattus norvegicus	0-11
4038942-2	1985	administration of 2 micrograms neurotensin, a brain and gastro-intestinal peptide which elicits various behavioral responses, diminishes grooming but stimulates paper shredding behavior of rats evoked by water immersion.	Water	204-209	neurotensin	Rattus norvegicus	31-42
3895827-4	1985	A comparison of the transit times for tablets taken together with 100 ml of cold carbonated water and 100 ml of lukewarm tap water showed a significantly better passage when the tablets were taken with cold carbonated water (p = 0.01).	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
3895827-4	1985	A comparison of the transit times for tablets taken together with 100 ml of cold carbonated water and 100 ml of lukewarm tap water showed a significantly better passage when the tablets were taken with cold carbonated water (p = 0.01).	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
3895827-5	1985	A similar advantage of carbonated liquids was seen when tablets were taken with 25 ml of lukewarm tap water as compared with 25 ml of cold carbonated water (p = 0.01).	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
2863947-3	1985	In the intestine, available information indicates that somatostatin may have an important regulatory role for water and electrolyte absorption and secretion.	Water	110-115	somatostatin	Homo sapiens	55-67
2863947-5	1985	The outcome associated with administration of somatostatin is inhibition of water and electrolyte secretion.	Water	76-81	somatostatin	Homo sapiens	46-58
3971193-5	1985	It appears likely that loss of water resulting in osmotic changes during infection is the major reason for the observed changes in prolactin concentration in infected cockerels.	Water	31-36	prolactin	Gallus gallus	131-140
3161696-2	1985	Dialysis of the dimethylformamide and sodium dodecyl sulphate column eluates against distilled water produced a precipitate that was fibrous and that resembled insoluble elastin fibers.	Water	95-100	elastin	Ovis aries	170-177
28164872-6	1985	The dermographic grade varied at different body sites and local applications of oil, talcum powder and even tap water lowered the dermographic grade.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
3851849-5	1985	With 1 kW of forward power to the antenna, the SAR [W/kg] = 45 exp(-0.607d) where d [cm] is the depth in water at any point within this area.	Water	105-110	sarcosine dehydrogenase	Homo sapiens	47-50
4046009-5	1985	The rate constant of efflux was estimated to be 15.6 +/- 1.0 sec-1 which would be consistent with a diffusive membrane water permeability Pd of 1.6 X 10(-3) cm sec-1 and an osmotic permeability Pos of between 0.3 X 10(-4) and 1.4 X 10(-4) cm sec-1 osmolar-1.	Water	119-124	secretory blood group 1, pseudogene	Homo sapiens	61-66
4046009-5	1985	The rate constant of efflux was estimated to be 15.6 +/- 1.0 sec-1 which would be consistent with a diffusive membrane water permeability Pd of 1.6 X 10(-3) cm sec-1 and an osmotic permeability Pos of between 0.3 X 10(-4) and 1.4 X 10(-4) cm sec-1 osmolar-1.	Water	119-124	secretory blood group 1, pseudogene	Homo sapiens	160-165
4046009-5	1985	The rate constant of efflux was estimated to be 15.6 +/- 1.0 sec-1 which would be consistent with a diffusive membrane water permeability Pd of 1.6 X 10(-3) cm sec-1 and an osmotic permeability Pos of between 0.3 X 10(-4) and 1.4 X 10(-4) cm sec-1 osmolar-1.	Water	119-124	secretory blood group 1, pseudogene	Homo sapiens	160-165
3920598-1	1985	The inhibition constants of several aldose reductase inhibitors were determined using water-soluble extracts of bovine and rat lenses.	Water	86-91	aldose reductase	Bos taurus	36-52
6540678-2	1984	When faced with this problem, we have had the patient ingest 250 cc of tap water.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
6706577-10	1984	However, tap water iontophoresis is gaining increasing significance as an effective and safe treatment in palmar and plantar hyperhidrosis.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
6317781-1	1984	Previous studies have shown that freezing and thawing of human thyroid homogenates releases a water-soluble substance which reversibly binds to TSH-receptor antibodies.	Water	94-99	thyroid stimulating hormone receptor	Homo sapiens	144-156
6100312-3	1984	Water flows into CSF along osmotic gradient produced by sodium pump.	Water	0-5	colony stimulating factor 2	Rattus norvegicus	17-20
6738466-8	1984	Our findings show that head-out water immersion induces significant increases in UCaV and UMgV by mechanisms which are independent of parathyroid hormone (PTH) or acid base changes.	Water	32-37	parathyroid hormone	Canis lupus familiaris	134-153
19373578-9	2009	CONCLUSIONS: These findings demonstrate that blockade of endogenous IL-17 activity by treatment with anti-IL-17 antibody attenuates EAU in rats.	Water	132-135	interleukin 17A	Rattus norvegicus	68-73
19373578-9	2009	CONCLUSIONS: These findings demonstrate that blockade of endogenous IL-17 activity by treatment with anti-IL-17 antibody attenuates EAU in rats.	Water	132-135	interleukin 17A	Rattus norvegicus	106-111
19302717-10	2009	The GM-CSF release was correlated to the organic component of the aerosols and especially its water soluble fraction.	Water	94-99	colony stimulating factor 2	Homo sapiens	4-10
19240903-0	2009	Fabrication of water soluble and biocompatible CdSe nanoparticles in apoferritin with the aid of EDTA.	Water	15-20	ferritin heavy chain 1	Homo sapiens	69-80
19240903-1	2009	Apoferritin-coated photoluminescent CdSe nanoparticles generated by an EDTA-mediated in situ method are photostable, water soluble and biocompatible.	Water	117-122	ferritin heavy chain 1	Homo sapiens	0-11
19350934-5	2009	Ten kinds of products through hydrolysis S(N)1 (C-Cl), elimination E1 or E2 (C-Cl, C-H), and addition-elimination (A-E) under the action of base sites and water from the degradation of HD over HCP were detected and identified by GC-FPD, GC-MS, and NMR approaches.	Water	155-160	small nucleolar RNA, H/ACA box 73A	Homo sapiens	67-75
19191886-3	2009	Two conceptual models are tested: (1) flux-controlled systems, in which ground water discharge to the sea is persistent despite changes in sea level, and (2) head-controlled systems, whereby ground water abstractions or surface features maintain the head condition in the aquifer despite sea-level changes.	Water	79-84	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	102-105
19191886-6	2009	This is in striking contrast to the constant head cases, in which the magnitude of salt water toe migration is on the order of hundreds of meters to several kilometers for the same sea-level rise.	Water	88-93	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	181-184
19178946-10	2009	In the present paper, we have used a water-soluble copper-N(3)S complex that mimics the Cu(B) site of DBH, and aromatic N-hydroxyguanidines as reducers to address this question.	Water	37-42	dopamine beta-hydroxylase	Homo sapiens	102-105
19178946-12	2009	These data describe for the first time the reactivity of N-aryl-N"-hydroxyguanidines with a water-soluble copper(II) complex and help to understand the interaction of co-substrates with copper at the active site of DBH.	Water	92-97	dopamine beta-hydroxylase	Homo sapiens	215-218
19209902-1	2009	Vasopressin-mediated control of water permeability in the renal collecting duct occurs in part through regulation of the distribution of aquaporin-2 (AQP2) between the apical plasma membrane and intracellular membrane compartments.	Water	32-37	aquaporin 2	Rattus norvegicus	137-148
19209902-1	2009	Vasopressin-mediated control of water permeability in the renal collecting duct occurs in part through regulation of the distribution of aquaporin-2 (AQP2) between the apical plasma membrane and intracellular membrane compartments.	Water	32-37	aquaporin 2	Rattus norvegicus	150-154
6229279-7	1983	The radius of gyration (Rg) and the shape of OSCP in H2O and D2O were studied by small-angle neutron scattering.	Water	53-56	ATP synthase peripheral stalk subunit OSCP	Bos taurus	45-49
19020292-3	2009	cAMP-dependent activation of protein kinase A phosphorylates the water channel aquaporin-2 and increases water permeability by insertion of aquaporin-2 into the apical cell membrane.	Water	65-70	aquaporin 2	Mus musculus	79-90
6229279-8	1983	The experimentally determined Rg value of OSCP in H2O was 24 +/- 1 A, and its Mr was 25 000 +/- 3000.	Water	50-53	ATP synthase peripheral stalk subunit OSCP	Bos taurus	42-46
6315978-4	1983	Spa water had high levels of Cl2 and Br2, tap water specimens had low levels of Cl2, and distilled water had no detectable Cl2 or Br2.	Water	4-9	surfactant protein A2	Homo sapiens	0-3
6315978-4	1983	Spa water had high levels of Cl2 and Br2, tap water specimens had low levels of Cl2, and distilled water had no detectable Cl2 or Br2.	Water	4-9	endogenous retrovirus group W member 5	Homo sapiens	29-32
6315978-5	1983	The addition of spa water to laboratory stock virus immediately inactivated the virus.	Water	20-25	surfactant protein A2	Homo sapiens	16-19
19020292-3	2009	cAMP-dependent activation of protein kinase A phosphorylates the water channel aquaporin-2 and increases water permeability by insertion of aquaporin-2 into the apical cell membrane.	Water	65-70	aquaporin 2	Mus musculus	140-151
19020292-3	2009	cAMP-dependent activation of protein kinase A phosphorylates the water channel aquaporin-2 and increases water permeability by insertion of aquaporin-2 into the apical cell membrane.	Water	105-110	aquaporin 2	Mus musculus	140-151
19212590-2	2009	RG1 features the high quantum efficiency for a Hg(2+)-bound sensor in natural water and sensitivity to environmentally relevant mercury in complex natural samples.	Water	78-83	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	0-3
6663066-2	1983	The disease was caused by repeated exposures to tap water aerosol.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
19084447-5	2009	Nevertheless, more potent and water-soluble small molecules are currently in development, and many X-ray crystallographic structures of Hsp90-inhibitor complexes are available for drug discovery purposes.	Water	30-35	heat shock protein 90 alpha family class A member 1	Homo sapiens	136-141
6316150-3	1983	There is a single, highly complementary position for O-2 to bind to both the Cu(II) and activity-important Arg 141 with correct geometry; two water molecules form a ghost of the superoxide in this position.	Water	142-147	immunoglobulin kappa variable 1D-39	Homo sapiens	53-56
6197724-2	1983	G/CCK-LI was extracted best in boiling water and was found mainly in the stomach, hemolymph and carapace.	Water	39-44	cholecystokinin	Mus musculus	2-5
19153469-0	2009	Structural and functional role of water molecules in bovine pancreatic phospholipase A(2): a data-mining approach.	Water	34-39	LOC104974671	Bos taurus	71-89
4059949-1	1985	Water boiling is recommended by health educators in Sri Lanka, and boiled water is given to ill and vulnerable people, but it is not widely consumed by the public.	Water	0-5	sorcin	Homo sapiens	52-55
19156806-2	2009	The water DCE interface essentially acts as a proton pump controlled by the Galvani potential difference across the interface, driving the proton transfer from water to DCE.	Water	4-9	ATPase H+/K+ transporting non-gastric alpha2 subunit	Homo sapiens	46-57
6525880-3	1984	Purified actin and vimentin were phosphorylated by a partially purified cAMP-dependent protein kinase isolated from the outer cortex water soluble fraction.	Water	133-138	vimentin	Bos taurus	19-27
6407854-11	1983	Among these proteins, both Mr 45 000 and Mr 57 000 proteins are probably constituents of the water-soluble cytoskeletal proteins, respectively actin and vimentin.	Water	93-98	vimentin	Bos taurus	153-161
19156806-2	2009	The water DCE interface essentially acts as a proton pump controlled by the Galvani potential difference across the interface, driving the proton transfer from water to DCE.	Water	160-165	ATPase H+/K+ transporting non-gastric alpha2 subunit	Homo sapiens	46-57
19096784-5	2009	AQP2 is expressed in principal cells of the collecting duct; in response to vasopressin, AQP2 translocates from intracellular vesicles to the apical plasma membranes, thereby increasing water permeability to concentrate urine (Nielsen et al.	Water	186-191	aquaporin 2	Homo sapiens	0-4
6847201-3	1983	The partial specific volume of LCAT was determined by sedimentation equilibrium ultracentrifugation experiments in H2O and D2O solutions (0.702 ml/g).	Water	115-118	lecithin-cholesterol acyltransferase	Homo sapiens	31-35
6441894-1	1984	Administration of cholecystokinin (CCK) (0.2 - 0.6 micrograms in a volume of 2 microliter) into the lateral cerebral ventricle caused a decrease in intake of food but a relative increase in intake of water (or water-to-food ratio) in rats.	Water	200-205	cholecystokinin	Rattus norvegicus	18-33
6441894-1	1984	Administration of cholecystokinin (CCK) (0.2 - 0.6 micrograms in a volume of 2 microliter) into the lateral cerebral ventricle caused a decrease in intake of food but a relative increase in intake of water (or water-to-food ratio) in rats.	Water	200-205	cholecystokinin	Rattus norvegicus	35-38
19096784-5	2009	AQP2 is expressed in principal cells of the collecting duct; in response to vasopressin, AQP2 translocates from intracellular vesicles to the apical plasma membranes, thereby increasing water permeability to concentrate urine (Nielsen et al.	Water	186-191	aquaporin 2	Homo sapiens	89-93
18949492-0	2009	Effects of immersion in water containing high concentrations of CO2 (CO2-water) at thermoneutral on thermoregulation and heart rate variability in humans.	Water	24-29	complement C2	Homo sapiens	69-78
6490782-0	1984	Quantitative determination of ppb levels of carbamate pesticides in water by capillary gas chromatography.	Water	68-73	histatin 1	Homo sapiens	30-33
6851522-1	1983	Nickel analyses of tap water from several sources in Copenhagen gave up to 490 X 10(-6) g X 1(-1) in the first 250 ml portions.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
18458931-6	2009	These observations imply that AQP5 expression in type I alveolar epithelial cells was suppressed by hypotonic water to prevent hemodilution from the physiological aspect.	Water	110-115	aquaporin 5	Homo sapiens	30-34
6304682-1	1983	The water flow according to the osmotic gradient increased under the action of 1 mU/ml of antidiuretic hormone (ADH) from 0,049 +/- 0.017 to 1.31 +/- 0.29 mcl/cm2 min in the presence of hemosorbent SKN in the solution of the frog bladder serous membrane and from 0.054 +/- 0.015 to 0.67 +/- 0.15 mcl/cm2 min without a sorbent.	Water	4-9	hedgehog acyltransferase	Homo sapiens	198-201
6547996-6	1984	Using hybridization analysis, we further show that the amount of rat preproCDD-ANF mRNA, which is synthesized selectively in the atria but not the ventricles, markedly decreases on water deprivation, suggesting that the water-electrolyte balance may be an important factor in the regulation of the expression of the preproCDD-ANF gene.	Water	181-186	natriuretic peptide A	Rattus norvegicus	79-82
6547996-6	1984	Using hybridization analysis, we further show that the amount of rat preproCDD-ANF mRNA, which is synthesized selectively in the atria but not the ventricles, markedly decreases on water deprivation, suggesting that the water-electrolyte balance may be an important factor in the regulation of the expression of the preproCDD-ANF gene.	Water	220-225	natriuretic peptide A	Rattus norvegicus	79-82
6547996-6	1984	Using hybridization analysis, we further show that the amount of rat preproCDD-ANF mRNA, which is synthesized selectively in the atria but not the ventricles, markedly decreases on water deprivation, suggesting that the water-electrolyte balance may be an important factor in the regulation of the expression of the preproCDD-ANF gene.	Water	220-225	natriuretic peptide A	Rattus norvegicus	326-329
6830036-1	1983	Water-soluble components of the gas phase of filtered cigarette smoke inhibit formation of covalent desmosine cross-links during conversion of tropoelastin to elastin in vitro.	Water	0-5	elastin	Homo sapiens	143-155
6830036-1	1983	Water-soluble components of the gas phase of filtered cigarette smoke inhibit formation of covalent desmosine cross-links during conversion of tropoelastin to elastin in vitro.	Water	0-5	elastin	Homo sapiens	148-155
18827834-0	2009	Quantitative assessment of water pools by T 1 rho and T 2 rho MRI in acute cerebral ischemia of the rat.	Water	27-32	brachyury 2	Rattus norvegicus	54-65
6817788-1	1982	By measuring the rate of exchange at chemical equilibrium of 18O between HCO3- and H2O catalyzed by human carbonic anhydrase II in the absence of buffers, we have determined the rate of release from the enzyme of water bearing substrate oxygen.	Water	83-86	carbonic anhydrase 2	Homo sapiens	106-127
6817788-1	1982	By measuring the rate of exchange at chemical equilibrium of 18O between HCO3- and H2O catalyzed by human carbonic anhydrase II in the absence of buffers, we have determined the rate of release from the enzyme of water bearing substrate oxygen.	Water	213-218	carbonic anhydrase 2	Homo sapiens	106-127
16663697-2	1984	The water-insoluble fraction, obtained after successive treatment of an insoluble fraction of a buffer-homogenate of Zea mays L. hybrid B73 x Mo 17 shoots with 3 molar LiCl and hot water, was treated with alpha-amylase to remove starch.	Water	4-9	alpha-amylase	Zea mays	205-218
20224195-7	2009	The frequency of water intake by E2F-1-deficient NOD/SCID mice was more than that by control mice.	Water	17-22	E2F transcription factor 1	Mus musculus	33-38
6466626-7	1984	The limiting value of k2/Km for the N-[p-(dimethylamino)benzoyl]-N"-methylimidazolium ion is 2.1 times less in D2O than in H2O.	Water	123-126	RBPJ pseudogene 3	Homo sapiens	22-27
7149035-4	1982	Wall motions resembling peristaltic ring contractions were induced in dialysis tubing filled with a concentrated salt solution and immersed in tap water.	Water	147-152	nuclear RNA export factor 1	Homo sapiens	143-146
19844828-2	2009	The goal of this work was to investigate the effect of administration of the water extract of clove over a short-term to BALB/c mice on Th1 (IFN-gamma and IL-2) and Th2 (IL-4 and IL-10) cytokine production.	Water	77-82	interleukin 2	Mus musculus	155-159
6753152-2	1982	In this system the catalytic activity of one of the enzymes studied (peroxidase) became much higher than in water, and the specificity of the other enzyme (alcohol dehydrogenase) was dramatically altered.	Water	108-113	aldo-keto reductase family 1 member A1	Homo sapiens	156-177
6721017-2	1984	Stratification of illness by consumption of municipal tap water showed a striking dose-response, with an attack rate of 42 per cent among persons who drank six or more glasses of water per day.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
19844828-2	2009	The goal of this work was to investigate the effect of administration of the water extract of clove over a short-term to BALB/c mice on Th1 (IFN-gamma and IL-2) and Th2 (IL-4 and IL-10) cytokine production.	Water	77-82	heart and neural crest derivatives expressed 2	Mus musculus	165-168
6721017-2	1984	Stratification of illness by consumption of municipal tap water showed a striking dose-response, with an attack rate of 42 per cent among persons who drank six or more glasses of water per day.	Water	179-184	nuclear RNA export factor 1	Homo sapiens	54-57
19844828-2	2009	The goal of this work was to investigate the effect of administration of the water extract of clove over a short-term to BALB/c mice on Th1 (IFN-gamma and IL-2) and Th2 (IL-4 and IL-10) cytokine production.	Water	77-82	interleukin 4	Mus musculus	170-174
6122550-1	1982	The effects of somatostatin on diarrhea and on small intestinal flow of water and electrolytes (slow-marker perfusion technique) in a patient with pancreatic cholera are reported.	Water	72-77	somatostatin	Homo sapiens	15-27
19177349-4	2009	Apart from the expulsion of several water molecules from the interface, Fab-Hyb3 binding results in major rearrangements (up to 5.5 A) of heavy chain residues Arg65, Gln72, Arg145, and Lys146.	Water	36-41	FA complementation group B	Homo sapiens	72-75
7118417-4	1982	The luminescence spectra of Zn2+- and Co2+-carboxypeptidase B in the presence of the metal coordinating ligand cyanide, used to displace the water from the metal coordination sphere, is also described.	Water	141-146	carboxypeptidase B1	Homo sapiens	43-61
6724293-0	1984	Growth hormone and prolactin secretion in water-deprived chickens.	Water	42-47	prolactin	Gallus gallus	19-28
6724293-1	1984	The deprivation of water for 12 or 24 hr increased the prolactin concentration in the plasma of immature chickens but had no effect on the circulating growth hormone (GH) level.	Water	19-24	prolactin	Gallus gallus	55-64
19123492-9	2008	As an illustration, the method is applied to an S(N)2 Menshutkin reaction in water, NH(3)+CH(3)Cl--&gt;NH(3)CH(3) (+)+Cl(-), for which free energy profiles are obtained at the Hartree-Fock, MP2, B3LYP, and BHHLYP levels by integrating the free energy gradient.	Water	77-82	tryptase pseudogene 1	Homo sapiens	190-193
6323433-3	1984	In this present study, we have investigated the hypothesis that iron-catalyzed formation of hydroxyl radical (.OH) from superoxide anion radical (O-.2) and H2O2 requires the availability of at least one iron coordination site that is open or occupied by a readily dissociable ligand such as water.	Water	291-296	immunoglobulin kappa variable 1D-39	Homo sapiens	146-150
16346487-3	1984	The salt content of the tap water and sewage water promoted virus adsorption, but evidently the organic compounds in sewage retarded adsorption.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
6461704-4	1982	Twenty-four dehydration followed by free access to tap water annihilated the protective effect of DOCA-saline pretreatment despite maintained depletion of renal renin.	Water	55-60	SEC14-like lipid binding 2	Rattus norvegicus	51-54
18834092-7	2008	We noticed that, for each addition of a water molecule, the change of the M-O distance in metal-water clusters is higher at the B3LYP than at the MP2 level.	Water	40-45	tryptase pseudogene 1	Homo sapiens	146-149
7083456-11	1982	Both VM26 and VP16-213 could be eluted isocratically (28% v/v acetonitrile in water) from a c18 column with retention times of 6.6 and 13.3 min, respectively.	Water	78-83	host cell factor C1	Homo sapiens	14-18
6697967-3	1984	Rats made hypothyroid by ingestion of methimazole (0.01% solution in drinking water for 30 days) demonstrated a significant 32% decrease in gastrin cell density (306 +/- 9/cm vs. 207 +/- 11/cm for controls) associated with a significant 50% decrease in serum gastrin (143 +/- 12 vs. 307 +/- 20 pg/ml for controls).	Water	78-83	gastrin	Rattus norvegicus	140-147
18834092-7	2008	We noticed that, for each addition of a water molecule, the change of the M-O distance in metal-water clusters is higher at the B3LYP than at the MP2 level.	Water	96-101	tryptase pseudogene 1	Homo sapiens	146-149
18852027-2	2008	We found that nordihydroguaiaretic acid (NDGA), a powerful antioxidant from Larrea tridentate, activates the antioxidant pathway Nrf2/heme oxygenase-1 (HO-1) in cerebellar granule neurons and protects them against H(2)O(2) or 3-nitropropionic acid-induced neurotoxicity.	Water	214-219	heme oxygenase 1	Homo sapiens	129-150
6715169-0	1984	[Tap water iontophoresis in the treatment of hyperhidrosis of the hands and feet].	Water	5-10	nuclear RNA export factor 1	Homo sapiens	1-4
7042260-0	1982	[Alcohol dehydrogenase substrate specificity in a colloidal solution of water in an organic solvent].	Water	72-77	aldo-keto reductase family 1 member A1	Homo sapiens	1-22
18852027-2	2008	We found that nordihydroguaiaretic acid (NDGA), a powerful antioxidant from Larrea tridentate, activates the antioxidant pathway Nrf2/heme oxygenase-1 (HO-1) in cerebellar granule neurons and protects them against H(2)O(2) or 3-nitropropionic acid-induced neurotoxicity.	Water	214-219	heme oxygenase 1	Homo sapiens	152-156
19081379-6	2008	In contrast, hippocampus-specific NR2B ablation spared hippocampus-dependent, hidden-platform water maze performance but induced a selective, short-term, spatial working memory deficit for recently visited places.	Water	94-99	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	34-38
18826913-3	2008	This is followed by a virtual screening docking study of the PU3 family of compounds and Hsp90 incorporating several conserved water molecules.	Water	127-132	heat shock protein 90 alpha family class A member 1	Homo sapiens	89-94
6563013-0	1984	Urinary kallikrein response to acute saline or water loads in hypertensive and normal humans.	Water	47-52	kallikrein related peptidase 4	Homo sapiens	8-18
6563013-1	1984	Urinary kallikrein excretion during acute water or saline loading was studied in normal and hypertensive humans after chronic Na+ depletion and Na+ loading to answer the following questions.	Water	42-47	kallikrein related peptidase 4	Homo sapiens	8-18
6563013-5	1984	During acute water or saline loading, does the underlying Na+ balance influence (a) the urinary kallikrein response?	Water	13-18	kallikrein related peptidase 4	Homo sapiens	96-106
6563013-6	1984	or (b) the relationship between urinary kallikrein and renal Na+ or water handling?	Water	68-73	kallikrein related peptidase 4	Homo sapiens	40-50
6563013-14	1984	(b) In Na+-restricted hypertensives given isotonic saline, urinary kallikrein was inversely related to the fractional excretion of Na+ (r = -0.54, p less than 0.01) and the tubular reabsorption of H2O (TcH2O/GFR; r = -0.50, p less than 0.01).	Water	197-200	kallikrein related peptidase 4	Homo sapiens	67-77
19061521-0	2008	ESKIMO1 is a key gene involved in water economy as well as cold acclimation and salt tolerance.	Water	34-39	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	0-7
6537965-3	1984	Water intake after subcutaneous injection of isoprenaline, a beta-adrenergic agonist which causes increased angiotensin biosynthesis, varied cyclically with the stage of the oestrous cycle.	Water	0-5	amyloid beta precursor protein	Rattus norvegicus	59-65
19061521-16	2008	Further experiments are being undertaken to elucidate the function of the ESKIMO1 protein and the way it modulates plant water uptake.	Water	121-126	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	74-81
18834890-7	2008	Most hydrogen-bond and weaker C-H...O interactions with inhibitors were conserved in the PR2 and PR1 complexes, except for small changes in interactions with water or disordered side chains.	Water	158-163	transmembrane protein 37	Homo sapiens	97-100
6423238-8	1984	The effect caused by xylitol and sorbitol was explained in terms of partial displacement of water molecules in the primary hydration layer of Ca(II) ions, caused by competition between polyol and water molecules.	Water	92-97	carbonic anhydrase 2	Homo sapiens	142-148
6423238-8	1984	The effect caused by xylitol and sorbitol was explained in terms of partial displacement of water molecules in the primary hydration layer of Ca(II) ions, caused by competition between polyol and water molecules.	Water	196-201	carbonic anhydrase 2	Homo sapiens	142-148
19047563-10	2008	Mean CSF opening pressure was 140.3 mm H2O (range 86 to 186).	Water	39-42	colony stimulating factor 2	Homo sapiens	5-8
6567478-1	1984	The antitumor and antimetastatic activities of the water-soluble peptidoglycan monomer GlnNAc-Mur-NAc-L-Ala-D-iso-Gln-meso-diamminopimelic acid (omega-NH2)-D-Ala-D-Ala (PGM), which has immunostimulant effects, have been evaluated in CBA mice bearing MCa mammary carcinoma.	Water	51-56	NLR family, pyrin domain containing 1A	Mus musculus	90-93
18829742-1	2008	Osmotic reabsorption of water through aquaporin-2 (AQP2) in the inner medulla is largely dependent on the urea concentration gradients generated by urea transporter (UT) isoforms.	Water	24-29	aquaporin 2	Mus musculus	38-49
6399309-6	1984	In control dogs, water deprivation increased plasma osmolality from 301 +/- 2 to 308 +/- 2 mosm/kg, plasma vasopressin from 2.0 +/- 0.3 to 6.8 +/- 1.3 pg/ml and plasma renin activity from 3.3 +/- 1.2 to 10.4 +/- 3.0 ng AI/ml/3 h and a natriuresis of 2 mEq of sodium/kg.	Water	17-22	renin	Canis lupus familiaris	168-173
6440264-3	1984	Nasal CPAP of 5-10 cm H2O decreased apnea index (apneas per hour of sleep) (control 35.1, n-CPAP 5.7; p less than 0.001) and significantly improved oxyhemoglobin saturation (SaO2).	Water	22-25	centromere protein J	Homo sapiens	6-10
6440264-3	1984	Nasal CPAP of 5-10 cm H2O decreased apnea index (apneas per hour of sleep) (control 35.1, n-CPAP 5.7; p less than 0.001) and significantly improved oxyhemoglobin saturation (SaO2).	Water	22-25	centromere protein J	Homo sapiens	92-96
6229279-5	1983	From the circular dichroism spectrum of OSCP, 43% alpha-helical structure was calculated; the dichroism spectra of OSCP in H2O and D2O were identical.	Water	123-126	ATP synthase peripheral stalk subunit OSCP	Bos taurus	115-119
6420999-3	1983	Whereas H2O and isosmotic passively absorbed substances (sorbose and urea) caused a very variable Cel drop, isosmotic actively absorbed nutrients elicited individually constant but interindividually different (glucose greater than alanine++ greater than arginine) changes due to solute coupled electrolyte free water transport.	Water	8-11	carboxyl ester lipase	Rattus norvegicus	98-101
6420999-10	1983	Cel rise after hypertonic solutions had the same latency as Cel drop after water.	Water	75-80	carboxyl ester lipase	Rattus norvegicus	60-63
6646503-0	1983	Interaction of cholecystokinin with vasoactive intestinal peptide in body shaking response to ice-water immersion in rats.	Water	98-103	cholecystokinin	Rattus norvegicus	15-30
6646503-1	1983	Interaction of cholecystokinin (CCK) with vasoactive intestinal peptide (VIP) in body shaking response to ice-water immersion was observed in pentobarbital-anesthetized rats.	Water	110-115	cholecystokinin	Rattus norvegicus	15-30
6646503-1	1983	Interaction of cholecystokinin (CCK) with vasoactive intestinal peptide (VIP) in body shaking response to ice-water immersion was observed in pentobarbital-anesthetized rats.	Water	110-115	cholecystokinin	Rattus norvegicus	32-35
6311560-2	1983	In the model system studied, tyrosinase oxidized [2,4,6,7-3H]-estradiol to [3H]-water and [3H]-estradiol metabolites, the latter of which formed ring-substituted conjugates with nucleophiles like monothioglycerol and BSA.	Water	80-85	tyrosinase	Homo sapiens	29-39
6871206-4	1983	Significant changes in tryptophan fluorescence of cytochrome b5 and in CD spectra of myoglobin in reversed micelles and their dependence on the [H2O]/[aerosol OT] ratio have been shown.	Water	145-148	cytochrome b5	Oryctolagus cuniculus	50-63
6866309-6	1983	d) Results in a characteristic change in certain coagulation parameters when compared with saline solution and tap water.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
6210217-2	1983	Isoosmotic CSF volume decrease in both experimental groups indicates that water-salt regulation in the body and brain tissues is performed by means of common neuro-humoral mechanisms with vasopressin participation.	Water	74-79	colony stimulating factor 2	Canis lupus familiaris	11-14
6846578-0	1983	Brain and CSF water and ions during dilutional and isosmotic hyponatremia in the rat.	Water	14-19	colony stimulating factor 2	Rattus norvegicus	10-13
6846578-2	1983	During DH, CSF [Na+], [Cl-], and osmolality decreased as predicted by passive dilution by the water load.	Water	94-99	colony stimulating factor 2	Rattus norvegicus	11-14
6344091-4	1983	Renin secretion increased significantly during application of CPPV with a positive and expiratory pressure of 10 cm water in the dogs of the intact group but was not altered in dogs of the denervated group.	Water	116-121	renin	Canis lupus familiaris	0-5
6838201-6	1983	We find that sulfhydryl agents of which water-soluble mercurials were most effective induce Ca2+ release.	Water	40-45	carbonic anhydrase 2	Homo sapiens	92-95
6549759-7	1983	We have used this technique to study the effect of alterations in sodium and water metabolism on kallikrein excretion.	Water	77-82	kallikrein related peptidase 4	Homo sapiens	97-107
6875437-3	1983	Individual blood lead can be considerably increased by raised household tap water lead concentrations.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
6875437-4	1983	Mean blood lead is estimated to be 43% higher for men when the concentration of lead in first-draw domestic tap water is 100 micrograms/l compared with a zero concentration.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
6844741-3	1983	0.05 M CaCl2 given to dams as tap water on days 8 through 20 of gestation inhibited ASA-induced hypocalcemic effect in maternal plasma.	Water	34-39	SEC14-like lipid binding 2	Rattus norvegicus	30-33
6844741-4	1983	Tap water of 0.002-0.05 M CaCl2, Ca(OH)2 and Ca-lactate on days 8 through 20 of gestation alleviated malformations elicited by the administration of ASA (500 mg/kg s.c.) on the 11th day of gestation resulting in a decrease in the fetotoxicity in rats.	Water	4-9	SEC14-like lipid binding 2	Rattus norvegicus	0-3
16662797-6	1983	Among those compounds possessing an o-dihydroxy function, the K(i)" for inhibition of lipoxygenase is directly related to the lipophilicity of the inhibitor as measured by the octanol-water partition coefficient.	Water	184-189	linoleate 9S-lipoxygenase-4	Glycine max	86-98
6371792-7	1983	n-CPAP was starting with pressure 8 cm H2O (0.8 kPa) and FIO2 0.5, if atelectasis with severe dyspnea, hypoxia and forced hyperventilation were found.	Water	39-42	centromere protein J	Homo sapiens	2-6
6757252-7	1982	This series of reactions requires the actions of T4-coded ribonucleoside diphosphate reductase and its associated reducing system, dCTP/dUTPase and dCMP hydroxymethylase, 3H being lost to water at the last step.	Water	188-193	Deoxyuridine triphosphatase	Drosophila melanogaster	131-143
6295992-3	1982	The increase in pulmonary vascular resistance (PVR) in control animals was sustained during the 75 min of study and was associated with an increase in the extravascular lung water content-to-bloodless dry lung weight ratio (W/D) from a normal value of 2.84 +/- 0.22 to 4.53 +/- 0.24 ml/g (P less than 0.01) after embolization.	Water	174-179	PVR cell adhesion molecule	Canis lupus familiaris	47-50
6762189-5	1982	To remove pyrogens and bacteria, tap water was subjected to activated charcoal, ion exchange and reverse osmosis treatment, followed by preparation of the dialysate.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
7103256-8	1982	Among never smokers, tap water copper was significantly and positively related to levels of both FVC (p = 0.014) and FEV1 (p = 0.027).	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
7084482-1	1982	Controls for glomerular filtration (GFR) and tubular transport of solutes and water are interrelated.	Water	78-83	Rap guanine nucleotide exchange factor 5	Homo sapiens	13-40
7085278-1	1982	A young blond woman developed green tinted hair from exposure to tap water containing excessive amounts of copper.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
7331547-4	1981	CSF absorption in hydrocephalic and normal rats varied linearly with perfusion pressures between -10 and 10 cm H2O.	Water	111-114	colony stimulating factor 2	Rattus norvegicus	0-3
18829742-1	2008	Osmotic reabsorption of water through aquaporin-2 (AQP2) in the inner medulla is largely dependent on the urea concentration gradients generated by urea transporter (UT) isoforms.	Water	24-29	aquaporin 2	Mus musculus	51-55
18988797-2	2008	We have previously reported that in normal cholangiocytes a subset of vesicles contain three proteins (ie, the water channel AQP1, the chloride channel CFTR, and the anion exchanger AE2) that account for ion-driven water transport.	Water	215-220	CF transmembrane conductance regulator	Rattus norvegicus	152-156
7199528-8	1982	However, brief exposure of isolated membrane to distilled water releases the synemin and vimentin together in nearly pure form, before the release of significant amounts of spectrin and actin.	Water	58-63	synemin	Homo sapiens	77-84
18926811-2	2008	Aquaporin 1 (AQP1) is one of the water channel proteins localized on the membranes of various cells including reproductive organs, allowing water to flow rapidly across the plasma membranes in the direction of osmotic gradients.	Water	33-38	aquaporin-1	Canis lupus familiaris	0-11
7059461-4	1982	When tumours were immersed in a water-bath at 43 degrees C for 1 h, Thermal Enhancement Ratios (TER) measured from the slopes of the dose-response curves were up to 1.6 for CCNU and 2.4 for Melphalan.	Water	32-37	cyclin O	Mus musculus	173-177
18926811-2	2008	Aquaporin 1 (AQP1) is one of the water channel proteins localized on the membranes of various cells including reproductive organs, allowing water to flow rapidly across the plasma membranes in the direction of osmotic gradients.	Water	33-38	aquaporin-1	Canis lupus familiaris	13-17
18926811-9	2008	Expression of AQP1 may be involved in the flux of water during the cryopreservation of spermatozoa.	Water	50-55	aquaporin-1	Canis lupus familiaris	14-18
6213368-2	1982	Our results indicate that SDS-swollen elastin is stiffer, stronger, and appears to fail at smaller extensions than water-swollen elastin.	Water	115-120	elastin	Homo sapiens	129-136
19096159-4	2008	Cognitive function was also normal in the tau mice evaluated in the radial arm water maze and the Y-maze tasks.	Water	79-84	microtubule associated protein tau	Homo sapiens	42-45
6213368-5	1982	The data for DMSO-swollen elastin corrected for swelling changes are virtually identical to those of water-swollen elastin but significantly different from those of SDS-swollen elastin.	Water	101-106	elastin	Homo sapiens	115-122
6213368-5	1982	The data for DMSO-swollen elastin corrected for swelling changes are virtually identical to those of water-swollen elastin but significantly different from those of SDS-swollen elastin.	Water	101-106	elastin	Homo sapiens	115-122
18551248-2	2008	METHOD: A small peptide, PC-1, as well as zinc PC-1 at (3:2) and (3:1) ratios, were dissolved in 44% (wt.%) of TBA/water, gradually frozen to -50 degrees C over 2 h ("typical freezing step"), annealed at -20 degrees C for 6 h ("annealing step"), and subsequently lyophilized with primary and secondary drying.	Water	115-120	polycystin 1, transient receptor potential channel interacting	Homo sapiens	25-29
18812183-9	2008	The LoD of immobilised PP-2A to MC-LR meets the WHO guideline of 1microgl(-1) for drinking water, and the sensitivity to OA (3.5microgl(-1)) would allow detection of DSP during the peak of some phytoplankton blooms.	Water	91-96	protein phosphatase 2 phosphatase activator	Homo sapiens	23-28
6962075-5	1982	The tap water of the region was found to be heavily polluted.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
6274030-2	1981	The dialysate was made up from a high level aluminium tap water.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
7033506-13	1981	In conclusion, water intake in response to partial aortic obstruction above the level of the kidneys is caused by renin released from the kidneys.	Water	15-20	renin	Canis lupus familiaris	114-119
6169847-2	1981	Cleavage performed in the presence of 0.15% Nonidet P-40 in water yielded polypeptides of approximately 40,000 (P40) and 25,000 (P25) Mr.	Water	60-65	tubulin polymerization promoting protein	Homo sapiens	129-132
7284311-14	1981	For optimal binding in the absence of Ca2+, a long-distance hydrogen bond between these two residues is required; this can be established via a water molecule.	Water	144-149	carbonic anhydrase 2	Homo sapiens	38-41
7246839-4	1981	Since the difference in 24-hour dietary sodium consumption was 300 milligrams between the communities, an intake of one liter of high sodium tap water represented approximately 25 per cent of the difference in total sodium intake between the two communities.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
6171052-3	1981	Final staining was by immersion in 2% potassium ferrocyanide which was followed by washing in tap water.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
7271067-6	1981	Compared to the lungs of normal mice, the lungs of Tsk/+ mice had a markedly increased total lung capacity of (1.8 +/- 0.1 ml versus 3.3 +/- 0.1 ml, p less than 0.001); compliance (0.077 +/- 0.006 ml/cm H2O versus 0.345 +/- 0.025 ml/cm H2O, p less than 0.001), and specific compliance (4.23 +/- 0.34% TLC/cm H2O versus 10.64 +/- 1.01% TLC/cm H2O, p less than 0.001).	Water	203-206	fibrillin 1	Mus musculus	51-54
7271067-6	1981	Compared to the lungs of normal mice, the lungs of Tsk/+ mice had a markedly increased total lung capacity of (1.8 +/- 0.1 ml versus 3.3 +/- 0.1 ml, p less than 0.001); compliance (0.077 +/- 0.006 ml/cm H2O versus 0.345 +/- 0.025 ml/cm H2O, p less than 0.001), and specific compliance (4.23 +/- 0.34% TLC/cm H2O versus 10.64 +/- 1.01% TLC/cm H2O, p less than 0.001).	Water	236-239	fibrillin 1	Mus musculus	51-54
7271067-6	1981	Compared to the lungs of normal mice, the lungs of Tsk/+ mice had a markedly increased total lung capacity of (1.8 +/- 0.1 ml versus 3.3 +/- 0.1 ml, p less than 0.001); compliance (0.077 +/- 0.006 ml/cm H2O versus 0.345 +/- 0.025 ml/cm H2O, p less than 0.001), and specific compliance (4.23 +/- 0.34% TLC/cm H2O versus 10.64 +/- 1.01% TLC/cm H2O, p less than 0.001).	Water	236-239	fibrillin 1	Mus musculus	51-54
7271067-6	1981	Compared to the lungs of normal mice, the lungs of Tsk/+ mice had a markedly increased total lung capacity of (1.8 +/- 0.1 ml versus 3.3 +/- 0.1 ml, p less than 0.001); compliance (0.077 +/- 0.006 ml/cm H2O versus 0.345 +/- 0.025 ml/cm H2O, p less than 0.001), and specific compliance (4.23 +/- 0.34% TLC/cm H2O versus 10.64 +/- 1.01% TLC/cm H2O, p less than 0.001).	Water	236-239	fibrillin 1	Mus musculus	51-54
7284359-2	1981	The 5-(n-alk(en)yl) resorcinols show a very high stability at the air/water interface.	Water	70-75	ALK receptor tyrosine kinase	Homo sapiens	9-12
7223825-3	1981	Prompt rinsing of the contaminated tonometer in running tap water for ten seconds proved sufficient to remove all detectable hepatitis B surface antigen from the tonometer.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
7264301-5	1981	One of them, L121, was found to be a powerful adjuvant for increasing antibody formation to BSA in mice when injected in an oil-in-water emulsion.	Water	131-136	skull morphology 17	Mus musculus	13-17
7289561-1	1981	Exposure to simulated weightlessness (7-day water immersion and 7-day head-down tilt) caused a decrease in the activity of malate (MDH) and isocitrate dehydrogenase (ICDH), and creatine phosphokinase dehydrogenase (ICDH), and creatine phosphokinase (CPK) at the expense of its MM isoform whereas the activity of alanine (ALT) and aspartate aminotransferase (AST) and pattern of distribution of MDH isoforms remained unchanged.	Water	44-49	malate dehydrogenase 2	Homo sapiens	131-134
7253184-8	1981	This resulted from refilling with tap water.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
7239135-2	1981	Recovery of CCK in 0.1 N NaOH extracts from gut mucosa, gut muscle, or whole gut ranged up to threefold higher than in similar water or 0.1 N HCl extracts, although the reverse was the case for the extraction of secretin from the same tissue.	Water	127-132	cholecystokinin	Rattus norvegicus	12-15
6792863-5	1981	In the 44 dehydrated sheep IVT infusion of 0.7 mannitol in Na-free artificial CSF was made for 6 h. The water deprivation as such caused a marked increase in plasma and CSF [Na] and osmolality.	Water	104-109	granulocyte-macrophage colony-stimulating factor	Ovis aries	169-172
7194913-6	1981	A similar protein was found in allantoic fluid of pregnant animals, suggesting that, like uteroferrin, it serves to transport a water-insoluble nutrient from the maternal uterine endometrium to the conceptus.	Water	128-133	acid phosphatase 5, tartrate resistant	Sus scrofa	90-101
7225516-0	1981	NMR relaxation of protein and water protons in methemoglobin solutions.	Water	30-35	hemoglobin subunit gamma 2	Homo sapiens	47-60
6111397-0	1981	[Renal excretion of kallikrein after water loading and administration of furosemide or the beta-adrenergic blocker, trimepranol.	Water	37-42	kallikrein related peptidase 4	Homo sapiens	20-30
7470468-4	1981	At a lower ionic strength, transitions are centered at 44, 61, 66, 70, 78, and 83 degrees C. The 42--44 degrees C endothermic transition (the A transition) can be correlated with the modification of three electron-transport components or properties associated with photosystem II: (i) release of manganese from the membrane, (ii) the loss of O2 evolution with water as a donor, and (iii) a decrease in the redox potential of the hydroquinone-reducible cytochrome b-559.	Water	360-365	mitochondrially encoded cytochrome b	Homo sapiens	452-464
6973022-22	1980	1976) was calculated to have a value of 0.209 x 10(-3) micrometer sec-1 H2O-1.	Water	72-75	secretory blood group 1, pseudogene	Homo sapiens	66-71
7432503-8	1980	We find that both purified and unpurified, water-swollen, single elastin fibres are optically isotropic, in agreement with the predictions of the kinetic theory of rubber elasticity.	Water	43-48	elastin	Homo sapiens	65-72
6903192-10	1980	These results suggest that the initial C3 convertase of the alternative pathway may be formed from native C3, without proteolysis, by the attack of a variety of nucleophiles including water.	Water	184-189	complement C3	Homo sapiens	39-41
6903192-10	1980	These results suggest that the initial C3 convertase of the alternative pathway may be formed from native C3, without proteolysis, by the attack of a variety of nucleophiles including water.	Water	184-189	complement C3	Homo sapiens	106-108
6903192-14	1980	These findings are consistent with the concept that native C3 contains an active carbonyl group, probably in the form of a thioester, which can either react with water to form functionally C3b-l;ike C3 or, upon enzymatic conversion of C3 to C3b, allows C3b to form an ester bond with hydroxyl groups on the target surface.	Water	162-167	complement C3	Homo sapiens	59-61
6903192-14	1980	These findings are consistent with the concept that native C3 contains an active carbonyl group, probably in the form of a thioester, which can either react with water to form functionally C3b-l;ike C3 or, upon enzymatic conversion of C3 to C3b, allows C3b to form an ester bond with hydroxyl groups on the target surface.	Water	162-167	complement C3	Homo sapiens	189-192
7422096-0	1980	Bombesin potently stimulates water intake in the pigeon.	Water	29-34	gastrin releasing peptide	Homo sapiens	0-8
6107910-0	1980	Somatostatin: an endogenous peptide in the toad urinary bladder inhibits vasopressin-stimulated water flow.	Water	96-101	somatostatin	Homo sapiens	0-12
6107910-4	1980	Somatostatin produced a dose-dependent, reversible inhibition of vasopressin-stimulated osmotic water flow; it inhibited theophylline-stimulated osmotic water flow but not the water flow stimulated by 8-p-chlorophenylthioadenosine 3",5"-cyclic monophosphate.	Water	96-101	somatostatin	Homo sapiens	0-12
6107910-4	1980	Somatostatin produced a dose-dependent, reversible inhibition of vasopressin-stimulated osmotic water flow; it inhibited theophylline-stimulated osmotic water flow but not the water flow stimulated by 8-p-chlorophenylthioadenosine 3",5"-cyclic monophosphate.	Water	153-158	somatostatin	Homo sapiens	0-12
6107910-4	1980	Somatostatin produced a dose-dependent, reversible inhibition of vasopressin-stimulated osmotic water flow; it inhibited theophylline-stimulated osmotic water flow but not the water flow stimulated by 8-p-chlorophenylthioadenosine 3",5"-cyclic monophosphate.	Water	153-158	somatostatin	Homo sapiens	0-12
6107910-8	1980	We propose that endogenous somatostatin may function as a local regulator of the cellular action of vasopressin on osmotic water flow.	Water	123-128	somatostatin	Homo sapiens	27-39
7421106-5	1980	Tap water as well as water with a salt concentration of 100 mg/lg occupy an intermediate position between desirable and undesirable waters but lie closer to the optimal variant.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
6988107-0	1980	An epidemic of extrinsic allergic alveolitis caused by tap water.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
6250824-2	1980	Alkylation at the N-1 position of the adenine moiety of NAD+, ADP or ATP with 2,3-epoxypropyl acrylate, followed by polymerization with or without acrylamide at pH 8, gave water-soluble polymers of NAD+ and ADP where the alkyl chain was located at the exocyclic adenine C-6 amino group.	Water	172-177	LOW QUALITY PROTEIN: complement component C6	Oryctolagus cuniculus	270-273
18790619-2	2008	Novel NIPA emulsion gels, i.e., NIPA hydrogels containing distributed oil (oleyl alcohol) microdroplets, were synthesized by means of an emulsion-gelation method in which the polymerization of hydrogels in an aqueous phase in an oil-in-water (O/W) emulsion and the loading of a lipophilic drug (indomethacin) dissolved in an oil phase were accomplished simultaneously.	Water	236-241	zinc finger C3HC-type containing 1	Homo sapiens	6-10
7384292-3	1980	Control animals receiving 5% glucose or tap water did not show this increase.	Water	44-49	SEC14-like lipid binding 2	Rattus norvegicus	40-43
18790619-2	2008	Novel NIPA emulsion gels, i.e., NIPA hydrogels containing distributed oil (oleyl alcohol) microdroplets, were synthesized by means of an emulsion-gelation method in which the polymerization of hydrogels in an aqueous phase in an oil-in-water (O/W) emulsion and the loading of a lipophilic drug (indomethacin) dissolved in an oil phase were accomplished simultaneously.	Water	236-241	zinc finger C3HC-type containing 1	Homo sapiens	32-36
18839943-3	2008	One common feature of many previous simulations is that there is a water molecule in the vicinity of the leaving CO2 group whose presence was only observed in the inhibitor bound complex of ODCase/BMP.	Water	67-72	bone morphogenetic protein 1	Homo sapiens	197-200
500641-2	1979	The physical properties of the detergent-extracted NGF receptor were assessed by Sepharose 6B chromatography and sucrose density gradient ultracentrifugation studies in H2O and D2O.	Water	169-172	LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16	Oryctolagus cuniculus	51-63
18839943-8	2008	To understand better the interactions between the enzyme and the inhibitor BMP molecule, simulations were also carried out to determine the binding free energy of this special water molecule in the ODCase/BMP complex.	Water	176-181	bone morphogenetic protein 1	Homo sapiens	75-78
18839943-8	2008	To understand better the interactions between the enzyme and the inhibitor BMP molecule, simulations were also carried out to determine the binding free energy of this special water molecule in the ODCase/BMP complex.	Water	176-181	bone morphogenetic protein 1	Homo sapiens	205-208
18839943-9	2008	The results indicate that the water molecule in the active site plays a significant role in the binding of BMP by contributing approximately -3 kcal/mol to the binding free energy of the complex.	Water	30-35	bone morphogenetic protein 1	Homo sapiens	107-110
94530-2	1979	In vivo neurotensin induced a dose-related inhibition of both water and protein basal secretion.	Water	62-67	neurotensin	Rattus norvegicus	8-19
19080500-10	2008	CONCLUSION: During HI, the downregulation of outward potassium (K+) conductance may prevent the emission of intracellularly accumulated K+ ions, thus resulting in osmotically derived water influx into astrocytes via aquaporin-4 and then cell swelling.	Water	183-188	aquaporin 4	Rattus norvegicus	216-227
466318-0	1979	Tap water instead of electrode jelly for electrocardiographic recording.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
18846592-4	2008	The conjugate is water soluble and specifically targets cancer cells that overexpress the glycolipid Gb3, the cellular Shiga toxin receptor that is found on several human tumours.	Water	17-22	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	101-104
466195-0	1979	Tap water for electrocardiographic recording.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
19137722-4	2008	Quantitative characteristics of microbial numbers and activity of the the key microbial processes occurring in the water column of the White Sea were explored.	Water	115-120	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	141-144
459996-0	1979	Can elevated levels of copper in drinking water precipitate aucte hemolysis in G-6-PD deficient individuals?	Water	42-47	glucose-6-phosphate dehydrogenase	Homo sapiens	79-85
19137722-9	2008	The bacterioplankton community of the White Sea"s deep water was found to be more stable than that of the surface layer.	Water	55-60	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	44-47
18816037-4	2008	This barrier is lowered in cyclic H-bonded systems of CO 2 with water dimer and water trimer in which preassociation complexes are formed with binding energies of approximately 7 and 15 kcal/mol, respectively.	Water	64-69	complement C2	Homo sapiens	54-58
447594-6	1979	The analysis of 300 L Ottawa tap water showed no detectable amounts (less than 1 ng/L) of any of the 16 organophosphorus pesticides.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
6907061-2	1981	Plasma prekallikrein was activated to kallikrein by exposure to 50 mg/L dextran sulfate in acetone/water (35/65 by vol) at 0 degrees C for 15 min.	Water	99-104	kallikrein related peptidase 4	Homo sapiens	10-20
18816037-4	2008	This barrier is lowered in cyclic H-bonded systems of CO 2 with water dimer and water trimer in which preassociation complexes are formed with binding energies of approximately 7 and 15 kcal/mol, respectively.	Water	80-85	complement C2	Homo sapiens	54-58
18816037-11	2008	An energy barrier of approximately 20 (gas phase) and a free energy barrier of approximately 19 (in water) kcal/mol were derived for the CO 2 + 4H 2O reaction, and again formation of an ion pair is important.	Water	100-105	complement C2	Homo sapiens	137-141
7011406-7	1981	Firstly, it was shown that for oxidation of isobutanol into isobutyraldehyde, catalyzed by alcohol dehydrogenase, the equilibrium shift that takes place in a water-hexane biphasic system is determined by the partition coefficients of the reagents found in an independent experiment.	Water	158-163	aldo-keto reductase family 1 member A1	Homo sapiens	91-112
455111-9	1979	Water deprivation for periods of 6, 12, 18 or 24 h increases plasma prolactin markedly but did not affect GH secretion significantly.	Water	0-5	prolactin	Gallus gallus	68-77
7011796-0	1981	Effect of NADH on the pKa of zinc-bound water in liver alcohol dehydrogenase.	Water	40-45	aldo-keto reductase family 1 member A1	Homo sapiens	55-76
18816037-12	2008	The calculated results confirm the crucial role of direct participation of three water molecules ( n = 3) in the eight-member cyclic TS for the CO 2 hydration reaction.	Water	81-86	complement C2	Homo sapiens	144-148
735476-1	1978	By installation of a warm water rotating pump type USp 20-KMR and the forming of a by-pass in the recirculation we could produce the underpressure necessary for the capillary dialysis.	Water	26-31	ubiquitin specific peptidase 20	Homo sapiens	51-57
18816037-13	2008	Carbonic acid and its water complexes are consistently higher in energy (by approximately 6-7 kcal/mol) than the corresponding CO 2 complexes and can undergo more facile water-assisted dehydration processes.	Water	22-27	complement C2	Homo sapiens	127-131
18816037-13	2008	Carbonic acid and its water complexes are consistently higher in energy (by approximately 6-7 kcal/mol) than the corresponding CO 2 complexes and can undergo more facile water-assisted dehydration processes.	Water	170-175	complement C2	Homo sapiens	127-131
18802082-7	2008	Surprisingly, superior protection against EAU was achieved with alpha-C-GalCer, which induces a strong IFN-gamma but only a weak IL-4 production by iNKT cells, in contrast to the ligands alpha-GalCer (both IFN-gamma and IL-4) and OCH (primarily IL-4).	Water	42-45	interleukin 4	Mus musculus	220-224
283392-0	1978	Phosphate (oxygen)-water exchange reaction catalyzed by human prostatic acid phosphatase.	Water	19-24	acid phosphatase 3	Homo sapiens	62-88
283392-2	1978	Studies conducted with human prostatic acid phosphatase by two independent methods have established that, despite earlier reports to the contrary, the enzyme catalyzes an exchange reaction between oxygen atoms of phosphate ion and of water.	Water	234-239	acid phosphatase 3	Homo sapiens	29-55
7344059-0	1981	[Occurrence of aqueous organisms in tap water.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
7344059-2	1981	Comparative studies of the tap water fed from a surface source and an infiltration well].	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
18802082-7	2008	Surprisingly, superior protection against EAU was achieved with alpha-C-GalCer, which induces a strong IFN-gamma but only a weak IL-4 production by iNKT cells, in contrast to the ligands alpha-GalCer (both IFN-gamma and IL-4) and OCH (primarily IL-4).	Water	42-45	interleukin 4	Mus musculus	220-224
681352-1	1978	The cyclic dodecapeptide analog of the linear polyhexapeptide of tropoelastin crystallizes from water on raising of the temperature and thereby demonstrates an inverse temperature transition implying dominant intermolecular hydrophobic interactions.	Water	96-101	elastin	Homo sapiens	65-77
18534058-5	2008	RESULTS: Twenty-four hours following tMCAO, the rAAV-VEGF group, with VEGF overexpression in the rats brain, showed a significantly increase in ICP, brain water content and cerebral edema volume compared with two control groups (p&lt;0.05).	Water	155-160	vascular endothelial growth factor A	Rattus norvegicus	53-57
566775-5	1978	Two of the 5 patients showed definite inhibition by concentrated tap water (TW) of IgG antibody against HW.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
6255807-1	1980	The time course of the water permeability response to synthetic arginine vasopressin (AVP) was examined in isolated perfused rabbit collecting tubules.	Water	23-28	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	86-89
6255807-2	1980	When experiments were conducted at 37 degrees C, addition of AVP in a concentration of 100 microU/ml increased hydraulic water permeability (Lp) from 18 +/- 4 X 10(-7) to 153 +/- 15 X 10(-7) cm x s-1 x atm-1.	Water	121-126	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	61-64
18534058-5	2008	RESULTS: Twenty-four hours following tMCAO, the rAAV-VEGF group, with VEGF overexpression in the rats brain, showed a significantly increase in ICP, brain water content and cerebral edema volume compared with two control groups (p&lt;0.05).	Water	155-160	vascular endothelial growth factor A	Rattus norvegicus	70-74
7459381-2	1980	High molecular weight water-soluble mucin was separated from low molecular weight proteins by gel exclusion chromatography on Sepharose 4B, and was further separated into two major mucin fractions and several non-mucin fractions on DEAE-cellulose.	Water	22-27	solute carrier family 13 member 2	Rattus norvegicus	36-41
18201928-3	2008	The modified CdS QDs are water-soluble, stable and highly luminescent.	Water	25-30	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
6165574-0	1980	The effects of intracerebroventricular administration of tonin on water drinking and blood pressure in rats.	Water	66-71	kallikrein 1-related peptidase C2	Rattus norvegicus	57-62
6165574-1	1980	Intraventricular administration of tonin, an enzyme which forms angiotensin II directly from a natural protein substrate (angiotensinogen), stimulated water drinking and increased systemic blood pressure in rats.	Water	151-156	kallikrein 1-related peptidase C2	Rattus norvegicus	35-40
6165574-4	1980	These results indicate that the central effects of tonin on water drinking and systemic blood pressure are mediated via the direct formation of angiotensin II in the brain, and suggest the possibility that the tonin-angiotensin II system in the central nervous system might be important in controlling water balance and blood pressure.	Water	60-65	kallikrein 1-related peptidase C2	Rattus norvegicus	51-56
211753-3	1978	Using concentrations up to 10(4) infectious units per ml representing a multiple quantity of the virus demonstrable in contaminated environmental waters all the viruses investigated could be inactivated reliably and rationally when suspended in tap water, more easily however in water of improved conductivity, by passing the current leading unit once.	Water	249-254	nuclear RNA export factor 1	Homo sapiens	245-248
18620011-1	2008	We report a simple method to microencapsulate erythropoietin (EPO, a protein easily denatured and antigenized by contact with water-organic solvent interfaces) into poly(lactic-co-glycolic acid) (PLGA) microspheres with minimal aggregation.	Water	126-131	erythropoietin	Mus musculus	46-60
650466-2	1978	Intracranial injections of the individual components of the renin-angiotensin system caused drinking in water-replete dogs.	Water	104-109	renin	Canis lupus familiaris	60-65
7417155-0	1980	Tap water, an efficient method for cooling heatstroke victims--a model in dogs.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
18620011-1	2008	We report a simple method to microencapsulate erythropoietin (EPO, a protein easily denatured and antigenized by contact with water-organic solvent interfaces) into poly(lactic-co-glycolic acid) (PLGA) microspheres with minimal aggregation.	Water	126-131	erythropoietin	Mus musculus	62-65
650466-14	1978	Dog renin substrate and synthetic renin substrate, injected intracranially in a dose of 10(-10) mole, produced similar intakes of water but these amounts were very much less than the volume drunk in response to the same dose of angiotensin II.	Water	130-135	renin	Canis lupus familiaris	4-9
650466-14	1978	Dog renin substrate and synthetic renin substrate, injected intracranially in a dose of 10(-10) mole, produced similar intakes of water but these amounts were very much less than the volume drunk in response to the same dose of angiotensin II.	Water	130-135	renin	Canis lupus familiaris	34-39
18620011-3	2008	EPO was first dissolved in water together with dextran (MW=70,000) and polyethylene glycol (MW=8000), followed by a freezing process during which dextran separated out as the dispersed phase with EPO partitioned in preferentially.	Water	27-32	erythropoietin	Mus musculus	0-3
7440043-4	1980	The symptoms appeared to be associated with exposure to water vapour derived from tap water.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	82-85
7440043-7	1980	Despite many efforts the specific causative agent in the tap water has not been identified.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
18761457-5	2008	Plotting the fragment ion abundances for ions formed from precursors with fewer than 11 water molecules as a function of hydration extent results in an energy resolved breakdown curve from which the appearance energies of the b 2 (+), y 2 (+), z 2 (+*), c 2 (+), and (KYK + H) (+) fragment ions formed from this peptide ion can be obtained; these values are 78, 88, 42, 11, and 9 kcal/mol, respectively.	Water	88-93	complement C2	Homo sapiens	254-257
33469-2	1978	The interaction of elementts found in tap water and in aquarium water is also investigated.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
21318981-9	2008	ET was not detected in the filtration unit, even though its level in the dialysate, which was reconstituted with tap water, was 806.2+-105.4 EU/L.	Water	117-122	filamin B	Homo sapiens	113-116
623734-4	1978	A new water-soluble form of lipophilin also containing over 70% alpha helix was obtained by a similar dialysis in the absence of lipid.	Water	6-11	proteolipid protein 1	Homo sapiens	28-38
7007558-4	1980	Occasionally tap water high in copper may be an important supplement to a diet low in copper.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
627160-4	1978	In spite of the increase of the internal pressure from 5 cm H2O to 100 cm H2O, the tension of the wall remains low or even decreases (roughly 500 dyn/mm2).	Water	74-77	PNMA family member 2	Homo sapiens	150-153
18698799-7	2008	Hg (2+) inhibited the water flux in AQP3-expressing cells irreversibly, while Ni (2+) blocked the AQP3 channels reversibly.	Water	22-27	aquaporin 3 (Gill blood group)	Homo sapiens	36-40
631124-1	1978	Highly glycosylated, water-soluble ABH-specific sphingolipids, designated macroglycolipids, were isolated in high yield, up to 5 mg per unit of blood, from the crude human-erythrocyte-membrane glycoprotein fraction which is obtained by extraction of the membranes with chloroform/methanol/water.	Water	21-26	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	35-38
7441139-1	1980	A retrospective case-control study was conducted to test the hypothesis that there is an association between the trace element content of domestic tap water and neural tube malformations in infants.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
18431594-4	2008	Driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels.	Water	43-48	aquaporin 2	Homo sapiens	82-86
6773783-3	1980	Administration of the irreversible inhibitor of ODC, alpha-difluoromethylornithine, DFMO, 2% inthe drinking water during days 5-8 of gestation, abolished the inareases in uterine ODC activity, putrescine and spermidine concentrations and enhanced the activity of SAMDC.	Water	108-113	ornithine decarboxylase, structural 1	Mus musculus	48-51
356509-3	1978	The original feature was a motor driven by water from an ordinary water tap.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	72-75
356509-3	1978	The original feature was a motor driven by water from an ordinary water tap.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	72-75
18431594-4	2008	Driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels.	Water	43-48	aquaporin 3 (Gill blood group)	Homo sapiens	135-139
6258472-1	1980	Simple, reliable, and efficient concentration of poliovirus from tap water was obtained with two types of electropositive filter media, one of which is available in the form of a pleated cartridge filter (Virozorb 1MDS).	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
6258472-2	1980	Virus adsorption from tap water between pH 3.5 and 7.5 was more efficient with electropositive filters than with Filterite filters.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
18431594-5	2008	When water homeostasis is restored, AVP levels decline, and AQP2 is internalized from the plasma membrane, leaving the plasma membrane watertight again.	Water	5-10	aquaporin 2	Homo sapiens	60-64
6258472-5	1980	Recovery of poliovirus from 1,000-liter tap water volumes was approximately 30% efficient with both Virozorb 1MDS and Filterite pleated cartridge filters, but the former were much simpler to use.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
6258472-6	1980	The virus adsorption behavior of these filters appears to be related to their surface charge properties, with more electropositive filters giving more efficient virus adsorption from tap water at higher pH levels.	Water	187-192	nuclear RNA export factor 1	Homo sapiens	183-186
20174369-1	1978	A laser beam of 1-mrad divergence in water focuses to a thin horizontal line when propagating down a horizontal plastic tube filled with aerated tap water of temperature less than ambient.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	145-148
18566824-5	2008	Among them, AQP2, the anti-diuretic hormone (ADH)-regulated water channel, plays a critical role in water reabsorption.	Water	60-65	aquaporin 2	Homo sapiens	12-16
754828-4	1978	Spin echo signals of proton nuclear spins in water molecules were detected RF (radio frequency) phase-sensitively in static magnetic field gradients which were superposed on a main magnetic field.	Water	45-50	spindlin 1	Homo sapiens	0-4
7419502-2	1980	The RR spectrum of neutral semiquinone of riboflavin-RBP complex in H2O solution has an intense line at 1617 cm-1, not observed for oxidized riboflavin bound to RBP.	Water	68-71	retinol binding protein 4	Homo sapiens	53-56
7005400-3	1980	Subcortical CCK extracted in boiling water and acetic acid was immunoabsorbed by an antiserum specific for the COOH-terminal sequence of CCK.	Water	37-42	cholecystokinin	Rattus norvegicus	12-15
18566824-7	2008	Upon ADH stimulation, AQP2 is translocated to the apical plasma membrane, where it serves in the influx of water.	Water	107-112	aquaporin 2	Homo sapiens	22-26
18839571-0	2008	[Biodegradation of LAS in the anaerobic water of a representative inlet of Lake Dianchi].	Water	40-45	lipoic acid synthetase	Homo sapiens	19-22
7403275-0	1980	Transmissiveness of ultrasound through tap water, glycerin, and mineral oil.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
7391015-3	1980	Cortical CCK extracted in boiling water and acetic acid was immunoabsorbed using an antiserum specific for the COOH-terminal sequence of CCK.	Water	34-39	cholecystokinin	Rattus norvegicus	9-12
6104568-9	1980	It is concluded that a sensitive, validated secretin radioimmunoassay should be one that is capable of detecting increments of plasma secretin in response to doses of intraduodenal acid at 0.055 mEq/min or lower and intravenous administration of exogenous secretin at 0.03 CU/kg/hr with concomitant stimulation of pancreatic bicarbonate and water secretion.	Water	341-346	secretin	Homo sapiens	44-52
6104568-9	1980	It is concluded that a sensitive, validated secretin radioimmunoassay should be one that is capable of detecting increments of plasma secretin in response to doses of intraduodenal acid at 0.055 mEq/min or lower and intravenous administration of exogenous secretin at 0.03 CU/kg/hr with concomitant stimulation of pancreatic bicarbonate and water secretion.	Water	341-346	secretin	Homo sapiens	134-142
6104568-9	1980	It is concluded that a sensitive, validated secretin radioimmunoassay should be one that is capable of detecting increments of plasma secretin in response to doses of intraduodenal acid at 0.055 mEq/min or lower and intravenous administration of exogenous secretin at 0.03 CU/kg/hr with concomitant stimulation of pancreatic bicarbonate and water secretion.	Water	341-346	secretin	Homo sapiens	134-142
7408860-1	1980	Fumarase does not catalyse 18O exchange between (2S,3R)-tartrate and solvent water, nor does it catalyse 2H or 3H exchange into (2S)-fluorosuccinate from isotopically labelled water.	Water	176-181	fumarate hydratase	Homo sapiens	0-8
6773984-9	1980	The localization of the enzyme and its inhibition by this drug suggest that further study of relationships amongst the glandular kallikrein-kinen system and renal ion and water transport is warranted.	Water	171-176	kallikrein related peptidase 4	Homo sapiens	129-139
7430049-3	1980	Aflatoxins B1, B2, G1, and G2 in the purified extract are resolved in ca 10 min by normal phase HPLC on a microparticulate (5 mum) silica gel column with a 50% water-saturated chloroform-cyclohexane-acetonitrile-ethanol solvent, and are measured by ultraviolet fluorescence in a silica gel-packed flowcell.	Water	160-165	anthocyanin regulatory R-S protein-like	Zea mays	11-29
6243999-10	1980	However, the formation of unilamellar vesicles produces a significant reduction of the internal volume and of the entrapped water-soluble spin lables.	Water	124-129	spindlin 1	Homo sapiens	138-142
7350058-0	1980	Effect of somatostatin infusion on jejunal water and electrolyte transport in a patient with secretory diarrhea due to malignant carcinoid syndrome.	Water	43-48	somatostatin	Homo sapiens	10-22
7350058-3	1980	Intestinal perfusion studies before intravenous somatostatin infusion revealed decreased water and sodium absorption and jejunal chloride secretion.	Water	89-94	somatostatin	Homo sapiens	48-60
7350058-4	1980	Somatostatin infusion for 2 hr (8 microgram/kg/hr) reversed chloride secretion to absorption and markedly enhanced water and sodium absorption.	Water	115-120	somatostatin	Homo sapiens	0-12
7350058-5	1980	These results suggest that somatostatin inhibited a secretory component of water and ion movement in the small bowel of the patient with malignant carcinoid syndrome.	Water	75-80	somatostatin	Homo sapiens	27-39
7390048-0	1980	Effect of pentagastrin, secretin and cholecystokinin on intestinal water and sodium absorption in the rat.	Water	67-72	cholecystokinin	Rattus norvegicus	37-52
6997039-0	1980	Evidence that ionization of zinc-bound water regulates the anion-binding capacity of the coenzyme-binding site in liver alcohol dehydrogenase.	Water	39-44	aldo-keto reductase family 1 member A1	Homo sapiens	120-141
6790379-0	1980	The effect of treatment with Hisar mineral water from the Momina-Salza spa on gastric secretion and acidity in duodenal ulcer patients - a study with pentagastrin (preliminary report).	Water	43-48	surfactant protein A2	Homo sapiens	71-74
7350175-0	1980	Relationship between urinary kallikrein and renal sodium handling during water immersion in normal man.	Water	73-78	kallikrein related peptidase 4	Homo sapiens	29-39
6989020-5	1980	In the patients, plasma prolactin levels were not decreased, but rather increased and urinary excretion of kallikrein and kinin was reduced significantly after water loading in the upright position.	Water	160-165	kallikrein related peptidase 4	Homo sapiens	107-117
6989020-6	1980	Thus, prolactin and urinary kallikrein-kinin system might also contribute to water and sodium retention in idiopathic edema, directly or indirectly through the augmentation of the action of ADH and of aldosterone.	Water	77-82	kallikrein related peptidase 4	Homo sapiens	28-38
510507-1	1979	The ingestion of 2 different water loads (7.5 and 15 ml/kg) by healthy subjects stimulated the release of plasma motilin, gastrin, pancreatic polypeptide and VIP.	Water	29-34	motilin	Homo sapiens	113-120
476163-0	1979	[Comparative study of the characteristics of the proton NMR spin echo decay of different globular proteins in water].	Water	110-115	spindlin 1	Homo sapiens	60-64
226761-0	1979	[Hemolytic anemia in chronically dialyzed patients induced by free chlorine in tap water (author"s transl)].	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
110618-0	1979	The water structure in the active cleft on human carbonic anhydrase B.	Water	4-9	carbonic anhydrase 2	Homo sapiens	49-69
466981-5	1979	Urine arsenic levels in Ajo children correlated positively with amount of tap-water consumed (r = .32, p less than.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
466981-7	1979	Tap-water drinkers had significantly higher urine arsenic levels than bottled water drinkers (t = 4.21 p less than .001).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
379049-3	1979	The active compound was available as a powder; the rinse consisted of 1.7 g powder dissolved in 30 ml hot tap water.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	106-109
444605-0	1979	[Effect of paramagnetic additives on the spin lattice relaxation of the protons of intracellular water].	Water	97-102	spindlin 1	Homo sapiens	41-45
728650-0	1978	The use of sea-water distillate for drinking purposes aboard a ship.	Water	15-20	inositol polyphosphate-5-phosphatase D	Homo sapiens	63-67
359237-0	1978	Stimulation of the renal kallikrein-linin system by vasoactive substances and its relationship to the excretion of salt and water.	Water	124-129	kallikrein related peptidase 4	Homo sapiens	25-35
366276-1	1978	The kallikrein-kinin system in the kidney is localized in the distal nephron, where it appears to be linked to processes that control water and electrolyte excretion.	Water	134-139	kallikrein related peptidase 4	Homo sapiens	4-14
725515-3	1978	Secretin (0.6 microgram per kg/h) was found to abolish the net absorption of water, Na+, and HCO3- and strongly reduce the net absorption of K+ and Cl-, whereas neither glucagon (1--20 microgram per kg/h) nor GIP (1--30 microgram per kg/h) was found to significantly influence the concentrating function of the gallbladder.	Water	77-82	secretin	Homo sapiens	0-8
596900-1	1977	Two silver-blond young women developed green, tinted hair from exposure to tap water containing excessive amounts of copper.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
588857-0	1977	Mortality and the concentration of elements in tap water in county boroughs in England and Wales.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
330831-3	1977	As the level of CPAP was increased in 2 cm H2O increments, changes in Pes were compared with changes in PaO2.	Water	43-46	centromere protein J	Homo sapiens	16-20
202896-3	1977	Samples of household tap water showed increased mercury concentrations (median 0.001 micromol/L).	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
406283-0	1977	Ultrasonic contrast study to indentify stomach tap water microbubbles.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
406283-2	1977	By giving the patient a drink of two or three ounces of freshly drawn water, multiple strong echoes are produced from the fundus and the body of the stomach because of the microbubbles contained in recently agitated tap water and the microbubbles produced by the mixing effect of swallowing.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	216-219
406283-2	1977	By giving the patient a drink of two or three ounces of freshly drawn water, multiple strong echoes are produced from the fundus and the body of the stomach because of the microbubbles contained in recently agitated tap water and the microbubbles produced by the mixing effect of swallowing.	Water	220-225	nuclear RNA export factor 1	Homo sapiens	216-219
263547-1	1977	The C-terminal octapeptide of cholecystokinin (CCK) was injected into water-deprived rats to observe the effect on water and milk intake.	Water	70-75	cholecystokinin	Rattus norvegicus	30-45
263547-1	1977	The C-terminal octapeptide of cholecystokinin (CCK) was injected into water-deprived rats to observe the effect on water and milk intake.	Water	70-75	cholecystokinin	Rattus norvegicus	47-50
263547-1	1977	The C-terminal octapeptide of cholecystokinin (CCK) was injected into water-deprived rats to observe the effect on water and milk intake.	Water	115-120	cholecystokinin	Rattus norvegicus	30-45
863843-3	1977	In an exercise lasting approximately 10 min, it was found that serum total protein (STP) would be a suitable parameter that could be used to calculate water content and actual decrease in water volume in blood due to exercise.	Water	151-156	thyroid hormone receptor interactor 10	Homo sapiens	63-82
863843-3	1977	In an exercise lasting approximately 10 min, it was found that serum total protein (STP) would be a suitable parameter that could be used to calculate water content and actual decrease in water volume in blood due to exercise.	Water	151-156	thyroid hormone receptor interactor 10	Homo sapiens	84-87
863843-3	1977	In an exercise lasting approximately 10 min, it was found that serum total protein (STP) would be a suitable parameter that could be used to calculate water content and actual decrease in water volume in blood due to exercise.	Water	188-193	thyroid hormone receptor interactor 10	Homo sapiens	63-82
863843-3	1977	In an exercise lasting approximately 10 min, it was found that serum total protein (STP) would be a suitable parameter that could be used to calculate water content and actual decrease in water volume in blood due to exercise.	Water	188-193	thyroid hormone receptor interactor 10	Homo sapiens	84-87
863843-4	1977	Further, it is described how STP values before and during hemoconcentration can be used to eliminate the effect of plasma water loss from the determined values of various solute levels in blood.	Water	122-127	thyroid hormone receptor interactor 10	Homo sapiens	29-32
559960-5	1977	Spinal tap showed an opening pressure of 90 mm of water and clear CSF with 62 mg/dl of protein content.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	7-10
192479-4	1977	The ESR spectra of probes which are highly insoluble in water exhibited line broadening due to intermolecular spin exchange interactions, indicating that the probes were concentrated in detergent aggregates present below the experimental cmc.	Water	56-61	spindlin 1	Homo sapiens	110-114
403544-4	1977	In addition, when given an opportunity to drink either saccharine solution or water 24 h later, Group MSN rats drank significantly less saccharin than any of the control groups.	Water	78-83	moesin	Rattus norvegicus	102-105
14101-5	1977	The increase in PVR induced by elevated ICP was correlated with increases in lung water, physiological shunt (Qs/Qt), alveolar dead space (VD), and with hypoxemia.	Water	82-87	PVR cell adhesion molecule	Canis lupus familiaris	16-19
843454-0	1977	Tap water iontophoresis in palmo-plantar hyperhidrosis.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
899932-2	1977	In TPTx rats, as well as in normal rats, bovine PTH induced a decrease in net calcium, sodium, and water absorption.	Water	99-104	parathyroid hormone	Bos taurus	48-51
139771-0	1977	The active center of methemoglobin Hb(H2O) investigated by Mossbauer and susceptibility experiments.	Water	38-41	hemoglobin subunit gamma 2	Homo sapiens	21-34
965373-21	1976	Substantial evidence supports the hypothesis that SCP1 operates as a noncatalytic carrier protein for the water-insoluble substrate squalene in the enzymatic conversion of squalene to lanosterol by liver microsomal membranes.	Water	106-111	synaptonemal complex protein 1	Rattus norvegicus	50-54
9181-4	1976	The water content of the crop did not change but that of the gizzard was at a minimum just after the ovulation and at a maximum 18 h later.	Water	4-9	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	25-29
18961935-2	1976	One of the resins was used for concentration of trace metal ions from dimineralized water, tap-water, and sea-water.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
769540-4	1976	Epidemiologic investigation showed that consumption of tap water was associated with illness in the initial cases of affected families.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
1253428-1	1976	We describe a simple, rapid process--which includes the specific precipitation of pre-beta and beta-lipoproteins with dextran sulfate and divalent metal ions--for preparing an optically clear human serum that retains its clarity upon reconstitution with water after having been frozen and lyophilized.	Water	254-259	prolactin regulatory element binding	Homo sapiens	82-90
444605-1	1979	Studies of the effects of Mn2+ and Fe3+ paramagnetic ions on spin-lattice relaxation of water protons in plant cells have shown that paramagnetic admixtures which are in the cells under normal conditions (in natural quantities) produce no significant effect on the rate of spin-lattice relation of water protons.	Water	88-93	spindlin 1	Homo sapiens	61-65
758986-4	1979	The data suggest that CHD may be associated with low concentrations of magnesium and chromium in the drinking water, but no definite relationship was found between water quality and sudden death.	Water	110-115	choline dehydrogenase	Homo sapiens	22-25
18839571-1	2008	Biodegradation and degradation kinetics of anion-surfactant (LAS) in the anaerobic water of a representative inlet (Haihe River) of Lake Dianchi under different incubation conditions were studied by the "river die-away" test method.	Water	83-88	lipoic acid synthetase	Homo sapiens	61-64
18839571-2	2008	The influences of temperature, pH, initial concentration of LAS, aeration condition and added nutrients (NH4Cl or NaH2PO4) on the biodegradation of LAS in the water were investigated.	Water	159-164	lipoic acid synthetase	Homo sapiens	148-151
282049-9	1978	in overhydrated rats given 2.5% and 0.5% NaCl and 5% of tap water/100 g body wt.	Water	60-65	SEC14-like lipid binding 2	Rattus norvegicus	56-59
1252430-1	1976	Peptide NH resonances in the 250 MHZ 1H nuclear magnetic resonance (NMR) spectrum of oxytocin in H2O were assigned to specific amino acid residues by the "underwater decoupling" technique (i.e., decoupling from corresponding CalphaH resonances, which are buried beneath the intense water peak).	Water	97-100	oxytocin/neurophysin I prepropeptide	Homo sapiens	85-93
1252430-1	1976	Peptide NH resonances in the 250 MHZ 1H nuclear magnetic resonance (NMR) spectrum of oxytocin in H2O were assigned to specific amino acid residues by the "underwater decoupling" technique (i.e., decoupling from corresponding CalphaH resonances, which are buried beneath the intense water peak).	Water	160-165	oxytocin/neurophysin I prepropeptide	Homo sapiens	85-93
18839571-3	2008	The results demonstrate that LAS can be biodegraded by microorganisms in the water and that the percentage of degradation of LAS was more than 95% after 26 d. The biodegradation of LAS fit the second kinetic model.	Water	77-82	lipoic acid synthetase	Homo sapiens	29-32
1252430-10	1976	As the solvet composition is gradually changed from dimethyl sulfoxide to H2O, oxytocin undergoes a conformational change at 70-90 mol % of H2O.	Water	74-77	oxytocin/neurophysin I prepropeptide	Homo sapiens	79-87
1252430-10	1976	As the solvet composition is gradually changed from dimethyl sulfoxide to H2O, oxytocin undergoes a conformational change at 70-90 mol % of H2O.	Water	140-143	oxytocin/neurophysin I prepropeptide	Homo sapiens	79-87
18450590-8	2008	The immunostaining of the glial water channel aquaporin-4 was increased in the outer retina, whereas the immunostaining of the photoreceptor water channel aquaporin-1 disappeared.	Water	32-37	aquaporin 4	Rattus norvegicus	46-57
1252430-11	1976	Exposure to solvent of specific hydrogens of oxytocin in H2O was studied by monitoring intensity changes of solute resonances when the solvent peak was saturated.	Water	57-60	oxytocin/neurophysin I prepropeptide	Homo sapiens	45-53
765162-0	1976	The renal kallikrein-kinin system and the regulation of salt and water excretion.	Water	65-70	kallikrein related peptidase 4	Homo sapiens	10-20
765162-5	1976	The excretion of water and dilution of urine are facilitated by the renal kallikrein-kinin system, even when antidiuretic hormone is high.	Water	17-22	kallikrein related peptidase 4	Homo sapiens	74-84
719822-1	1978	Raman spectra are obtained for the multilayer dispersion of rac-1,2,dioctadec-9"-cis-enyl-glycero-3-phosphorylcholine (dietherlecithin) in excess water.	Water	146-151	Rac family small GTPase 1	Homo sapiens	60-65
18450595-3	2008	METHODS: Lewis rats were immunized with S-antigen mixed with complete Freund adjuvant (CFA) to induce EAU.	Water	102-105	S-antigen visual arrestin	Rattus norvegicus	40-49
18348164-1	2008	Na(+) transport via epithelial Na(+) channel (ENaC) occurs across many epithelial surfaces and plays a key role in regulating salt and water absorption.	Water	135-140	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	20-44
708754-4	1978	The water-soluble proteins such as myelin basic protein and P2 protein were extracted leaving a glycoprotein-rich residue, from which the PO protein was isolated.	Water	4-9	myelin basic protein	Oryctolagus cuniculus	35-55
1027342-2	1976	a) In a first analytical chapter, we have made the schedule and the critical examination of the different reproaches given to conditioned waters on considering successively: 1) Special drawbacks (although these are of an other category than microbiology) which were given, whichever type of supply (loose, at the tap, or splitted up when the water is conditioned), to some categories of waters (carbonated and mineral) because of their nature by the fact that these waters do not show the charactheristics of potability with regard to the legislation and administration.	Water	138-143	nuclear RNA export factor 1	Homo sapiens	313-316
769752-3	1976	Approximately 10 plaque forming units, concentrated from a volume of 40 liters of seeded tap water could be demonstrated by the rapid method.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
18348164-1	2008	Na(+) transport via epithelial Na(+) channel (ENaC) occurs across many epithelial surfaces and plays a key role in regulating salt and water absorption.	Water	135-140	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	46-50
699406-1	1978	Chloramines, compounds made up of chlorine and ammonia, when present in tap water used for dialysis cause methemoglobinemia and hemolysis.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
699406-9	1978	We conclude that addition of ascorbic acid to neutralize chloramines in tap water is also effective when using the proportioning dialysis delivery system.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
18547104-3	2008	Transparent and highly viscous dispersions of squid pen beta-chitin nanofibers in water can be obtained by this method.	Water	82-87	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	52-55
29320-4	1978	A Bronsted slope (alpha) of 0.71 was obtained for the acid (including H3O+) catalytic constants, from which a pH independent first-order rate constant for the spontaneous hydrolysis (catalyzed by H2O as a general acid) was estimated to be 1.3 x 10(-6) sec-1.	Water	196-199	secretory blood group 1, pseudogene	Homo sapiens	252-257
97011-1	1978	Breeding of Pleurodeles waltii larvae with female gentotype was carried out in 29,5-30 degrees C tap water within 4 months after hatching.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
5770-7	1976	Superimposed intravenous infusion of secretin and cholecystokinin increased acid disposal, particularly in patients with duodenal ulcer, and increased the associated rate of secretion of water and electrolytes or changed net absorption to net secretion.	Water	187-192	secretin	Homo sapiens	37-45
1202509-7	1975	The LET of light tracks was therefore in the range 1-10 keV mum-1 in emulsion, scaling to 0-4-4 keV mum-1 in water.	Water	109-114	PWWP domain containing 3A, DNA repair factor	Homo sapiens	100-105
1202509-8	1975	Heavy tracks have LET values in excess of 4 keV mum-1 in water.	Water	57-62	PWWP domain containing 3A, DNA repair factor	Homo sapiens	48-53
18593933-2	2008	Gene expression profiles of A549 cultures treated with one of these water-soluble zinc ionophores, PCI-5002, reveal the activation of stress response pathways under the control of metal-responsive transcription factor 1 (MTF-1), hypoxia-inducible transcription factor 1 (HIF-1), and heat shock transcription factors.	Water	68-73	metal response element binding transcription factor 1	Mus musculus	180-219
1103307-7	1975	The use of tap water for enemas has produced morbidity both from thermal injuries and from electrolyte depletion.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
667752-2	1978	The data show that hot water epilepsy is a benign form of reflex epilepsy occurring mainly in children.	Water	23-28	alcohol dehydrogenase iron containing 1	Homo sapiens	19-22
18593933-2	2008	Gene expression profiles of A549 cultures treated with one of these water-soluble zinc ionophores, PCI-5002, reveal the activation of stress response pathways under the control of metal-responsive transcription factor 1 (MTF-1), hypoxia-inducible transcription factor 1 (HIF-1), and heat shock transcription factors.	Water	68-73	metal response element binding transcription factor 1	Mus musculus	221-226
1202707-1	1975	The article deals with the hydrophobic character (distribution coefficient in the systems hexane - water and chloroform - water) and certain peculiarities of distributing three cation-containing phosphoroganic inhibitors of cholinesterase and their uncharged analogues in the organisms.	Water	99-104	cholinesterase	Oryctolagus cuniculus	224-238
1202707-1	1975	The article deals with the hydrophobic character (distribution coefficient in the systems hexane - water and chloroform - water) and certain peculiarities of distributing three cation-containing phosphoroganic inhibitors of cholinesterase and their uncharged analogues in the organisms.	Water	122-127	cholinesterase	Oryctolagus cuniculus	224-238
25048-0	1978	Concentration of poliovirus from tap water onto membrane filters with aluminum chloride at ambient pH levels.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
18340454-3	2008	In addition, we tested the hypothesis whether tight junctions and orthogonal arrays of particles (OAPs) which contain the water channel protein aquaporin-4 (AQP4), are mutually exclusive as suggested in previous studies.	Water	122-127	aquaporin 4	Rattus norvegicus	144-155
25048-1	1978	A method is described for the concentration of an enterovirus from large volumes of tap water by addition of small amounts of aluminum chloride to enhance virus removal by membrane filters.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
25048-2	1978	Tap water treated with 2 X 10(-5) M aluminum chloride showed a slight decrease in pH (less than 0.5), a slight increase in turbidity, and enhanced removal of poliovirus by membrane filters.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
18340454-3	2008	In addition, we tested the hypothesis whether tight junctions and orthogonal arrays of particles (OAPs) which contain the water channel protein aquaporin-4 (AQP4), are mutually exclusive as suggested in previous studies.	Water	122-127	aquaporin 4	Rattus norvegicus	157-161
205175-5	1978	With this procedure, poliovirus in large volumes of tap water, seawater, and sewage could be concentrated with an average efficiency of 52, 53, and 50%, respectively.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
1242084-2	1975	Longitudinal and transverse proton relaxation rates of water in solutions of porcine manganese carboxypeptidase B have been measured in the presence of various competitive inhibitors by pulse nuclear magnetic resonance (NMR) spectrometry.	Water	55-60	carboxypeptidase B1	Homo sapiens	95-113
18239616-1	2008	Filaggrin is an abundant protein of the outer epidermis that is essential for terminal differentiation of keratinocytes and formation of an effective barrier against water loss and pathogen/allergen/irritant invasion.	Water	166-171	filaggrin	Homo sapiens	0-9
237865-6	1975	These observations are compatible with a direct effect of secretin upon the renal tubular reabsorption of water, bicarbonate, and other ions, and could account for the transient alterations in urinary pH occurring in response to a meal.	Water	106-111	secretin	Homo sapiens	58-66
49948-9	1975	Wash in running tap water for 1 minute.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
80847-4	1978	Staining procedure: wash formalin-fixed brain slices overnight in running tap water.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
18601373-11	2008	In the PA-D PES, the hydrogen-water pair potential is described by the ab initio 5D PES of the isolated H(2)-H(2)O dimer.	Water	30-35	peptidyl arginine deiminase 4	Homo sapiens	7-11
80847-6	1978	Wash in running tap water.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
80847-8	1978	Wash in running tap water.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
164233-7	1975	Adrenal ferredoxin was the third subject in our studies of the intermediate states of proteins which appear after reduction of their active centres by means of electrons trapped in water-ethylene glycol mixtures at the temperature of liquid nitrogen [1, 2].	Water	181-186	ferredoxin 1	Homo sapiens	0-18
18442866-7	2008	In this particular case it could be shown that the precipitation effect of PEG on IFN-alpha in water-filled pores plays a crucial role for the overall control of protein release.	Water	95-100	progestagen associated endometrial protein	Homo sapiens	75-78
164224-11	1975	Measurements of the effect of gadolinium-protein binding on the relaxation rate of solvent water protons enable the enzyme-bound spin label-metal ion distances to be tentatively estimated as 15 angstrom.	Water	91-96	spindlin 1	Homo sapiens	129-133
643590-0	1978	[The tap water dressing].	Water	9-14	nuclear RNA export factor 1	Homo sapiens	5-8
18457818-3	2008	Here, we find that EGCG administered orally in drinking water (50 mg/kg) similarly reduces Abeta deposition in these mice.	Water	56-61	amyloid beta (A4) precursor protein	Mus musculus	91-96
340159-1	1978	In 12 patients requiring therapy with mechanical ventilation for acute respiratory failure, total static compliance (Cst) increased from 29 +/- 4 ml/cm H2O at a tidal volume (TV) of 5 ml/kg to 42 +/- 7 ml/cm H2O at a TV of 15 ml/kg.	Water	152-155	cystatin 12, pseudogene	Homo sapiens	117-120
18167118-2	2008	On the other hand, AQP4 has been considered to be a mercury-insensitive water channel because it does not have the reactive cysteine residue corresponding to Cys(189) of AQP1.	Water	72-77	aquaporin 4	Rattus norvegicus	19-23
340159-1	1978	In 12 patients requiring therapy with mechanical ventilation for acute respiratory failure, total static compliance (Cst) increased from 29 +/- 4 ml/cm H2O at a tidal volume (TV) of 5 ml/kg to 42 +/- 7 ml/cm H2O at a TV of 15 ml/kg.	Water	208-211	cystatin 12, pseudogene	Homo sapiens	117-120
340159-2	1978	Similarly, Cst increased from 42 +/- 7 ml/cm H2O to 52 +/- 8 ml/cm H2O between 0 and 6 cm H2O of positive end-expiratory pressure (PEEP).	Water	45-48	cystatin 12, pseudogene	Homo sapiens	11-14
340159-2	1978	Similarly, Cst increased from 42 +/- 7 ml/cm H2O to 52 +/- 8 ml/cm H2O between 0 and 6 cm H2O of positive end-expiratory pressure (PEEP).	Water	67-70	cystatin 12, pseudogene	Homo sapiens	11-14
1114295-0	1975	[Determination of lead and copper content in tap water in the Poznan Province].	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
340159-2	1978	Similarly, Cst increased from 42 +/- 7 ml/cm H2O to 52 +/- 8 ml/cm H2O between 0 and 6 cm H2O of positive end-expiratory pressure (PEEP).	Water	67-70	cystatin 12, pseudogene	Homo sapiens	11-14
18167118-5	2008	RESULTS: The water permeability of AQP4 proteoliposomes with or without HgCl2 was measured with a stopped-flow apparatus.	Water	13-18	aquaporin 4	Rattus norvegicus	35-39
18436250-11	2008	This long-term down-regulation of aquaporin 1 and 2 provides important molecular evidence for a defect in resorptive capacity of water induced by vesicoureteral reflux.	Water	129-134	aquaporin-1	Ovis aries	34-51
620492-0	1978	The relationship of urinary kallikrein activity to renal salt and water excretion.	Water	66-71	kallikrein related peptidase 4	Homo sapiens	28-38
4457185-0	1974	A rapid and reliable in situ spectrophotofluorometric method for the analysis of Co-Ral and bayrusil in lake and sewage water.	Water	120-125	RAS like proto-oncogene A	Homo sapiens	84-87
18299255-6	2008	These results suggest that AM2/intermedin in the hypothalamus and brainstem may play roles on neuroendocrine and autonomic functions, such as water/salt balance, in rats.	Water	142-147	adrenomedullin 2	Rattus norvegicus	27-30
4857830-0	1974	Action of pancreatic lipase on monomeric tripropionin in the presence of water-miscible organic compounds.	Water	73-78	pancreatic lipase	Homo sapiens	10-27
318329-2	1978	Increases in hepatic ATP citrate lyase specific activity and in serum thyroxine levels were observed in immature chicks in response to either controlled food and water intakes at 22 degrees C, or an elevation in environmental temperature to 30 degrees C. Hepatic phosphofructokinase specific activity was reduced at the higher temperature.	Water	162-167	ATP citrate lyase	Homo sapiens	21-38
618993-2	1978	The conversion of prekallikrein to kallikrein is achieved by cold activation (0 degrees C) with water-soluble dextran sulfate.	Water	96-101	kallikrein related peptidase 4	Homo sapiens	21-31
18299255-6	2008	These results suggest that AM2/intermedin in the hypothalamus and brainstem may play roles on neuroendocrine and autonomic functions, such as water/salt balance, in rats.	Water	142-147	adrenomedullin 2	Rattus norvegicus	31-41
4825171-0	1974	[Stability of ED-5 brand epoxy resin in water].	Water	40-45	ectodysplasin A receptor	Homo sapiens	14-18
18483193-4	2008	In the C-terminal region of TM-C, a crucial water in the coiled-coil core broke the local 2-fold symmetry and helps generate a kink on one helix.	Water	44-49	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	28-32
4851040-0	1974	Cleavage by beta-glucuronidase of the water-soluble metabolites of digitoxin excreted in the bile of control and spironolactone-pretreated rats.	Water	38-43	glucuronidase, beta	Rattus norvegicus	12-30
602442-4	1977	Prerinsing for 2 min with cold tap water removes 91.25 percent of the quantity of casein originally present.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
18205346-4	2008	Type i: Myoglobin and a ligand embedded in a periodic box with 9996 water molecules; the water molecules are rigid but the bonds of the protein are flexible.	Water	68-73	myoglobin	Homo sapiens	8-17
911824-3	1977	The loss of water oxidizing activity perfectly correlated with the decrease in amplitude of cytochrome b-559 reduction.	Water	12-17	mitochondrially encoded cytochrome b	Homo sapiens	92-104
4521206-1	1973	The 300-MHz nuclear magnetic resonance spectrum of the peptide hormone, oxytocin, in water, was obtained.	Water	85-90	oxytocin/neurophysin I prepropeptide	Homo sapiens	72-80
4779084-0	1973	Radiostrontium in tap water, January-December 1972.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
4748252-1	1973	A defect potentiated by tap water hemodialysis.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
30731532-5	1977	Under comparable conditions of application, both sodium hypochlorite (200 to 250 mg/liter) and tap water reduced counts by about 90%.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
18205346-4	2008	Type i: Myoglobin and a ligand embedded in a periodic box with 9996 water molecules; the water molecules are rigid but the bonds of the protein are flexible.	Water	89-94	myoglobin	Homo sapiens	8-17
4518359-1	1973	In laboratory experiments the acute eye irritation produced by exposure to tap water was not significantly increased when chlorine compounds were added to the water at concentrations of 1 mg./l.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
18205346-5	2008	Type ii: Myoglobin with a solvation shell (153 water molecules) in which all bond lengths are fixed.	Water	47-52	myoglobin	Homo sapiens	9-18
18311963-3	2008	LNM analysis of myosin II indicates that all ENM-like modes are overdamped at water viscosities.	Water	78-83	myosin heavy chain 14	Homo sapiens	16-22
5039996-0	1972	The relationship between urinary kallikrein, renal function and the excretion of sodium and water.	Water	92-97	kallikrein related peptidase 4	Homo sapiens	33-43
18202915-1	2008	The cholinesterase (ChE)-inhibiting activity of water and the concentrations of representative inhibitors were monitored in the Tone canal, Japan, during April to December 2006.	Water	48-53	butyrylcholinesterase	Homo sapiens	20-23
4551228-0	1972	Spin echo studies on cellular water.	Water	30-35	spindlin 1	Homo sapiens	0-4
406941-3	1977	"Unstirred" water layer thickness delta is determined concurrently, from the frequency dependence of P(omega); the result for frog skin is delta = (0.060 +/- 0.016) square root of omega(rad/s) cm.	Water	12-17	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	186-189
18202915-4	2008	The water samples were treated with chlorine to enhance the ChE-inhibiting activity by conversion of thiophosphate pesticides to phosphate pesticides.	Water	4-9	butyrylcholinesterase	Homo sapiens	60-63
18202915-6	2008	These results suggested that assay of ChE-inhibiting activity is important for evaluating the ecotoxicity of environmental water, because toxicological investigations based solely on inhibitor concentrations may underestimate the contamination.	Water	123-128	butyrylcholinesterase	Homo sapiens	38-41
4378027-1	1972	Phentolamine-induced blockade of alpha-adrenoreceptors and subsequent beta-adrenoreceptor stimulation by intravenous injection of adrenaline or phenylephrine (Mezaton) in anaesthtized dogs was accompanied by an elevation of plasma renin activitiy in peripheral blood and a reduction of renal excretion of sodium, potassium, and water.	Water	328-333	renin	Canis lupus familiaris	231-236
329637-2	1977	Moreover, brown or black flakes were often present in tap water, as well as in the water lines of dental equipment.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
18543808-11	2008	"If we understood how the brain knew how to pick up a glass of water and drink it, that would represent a major achievement," he says.	Water	63-68	protein interacting with PRKCA 1	Homo sapiens	44-48
16881-1	1977	The hemoglobin oxidation Bohr effect is larger than the ligation Bohr effect, even when the former is corrected for any ionization of the water molecule bound to the ferric iron of methemoglobin.	Water	138-143	hemoglobin subunit gamma 2	Homo sapiens	181-194
18088-5	1977	Reconcentration methods described previously for eluates from filters that process tap water or treated wastewater were inadequate when applied to eluates from filters used to process estuarine water containing large amounts of organic compounds.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
189808-11	1977	These water-soluble spin labels mimic ionic or nonionic solutes.	Water	6-11	spindlin 1	Homo sapiens	20-24
192145-0	1977	Regeneration of pleated filters used to concentrate enteroviruses from large volumes of tap water.	Water	92-97	nuclear RNA export factor 1	Homo sapiens	88-91
192145-1	1977	Pleated cartridge filters are capable of concentrating enteroviruses from large volumes (well over 2,000 liters) of tap water.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
842178-1	1977	Some strains of NAG vibrios isolated from the stool of patients with diarrhoeal disease as well as from surface water caused an accumulation of fluid in the ligated rabbit gut loop.	Water	112-117	NBAS subunit of NRZ tethering complex	Homo sapiens	16-19
868663-3	1977	For two bifunctional solvents, water and ethylene glycol, the molar ratio "bound solvent/elastin residue" was the same for all the elastin samples investigated, and very close to 1.5.	Water	31-36	elastin	Homo sapiens	89-96
868663-3	1977	For two bifunctional solvents, water and ethylene glycol, the molar ratio "bound solvent/elastin residue" was the same for all the elastin samples investigated, and very close to 1.5.	Water	31-36	elastin	Homo sapiens	131-138
868663-4	1977	This result is identical to that obtained by other workers for the "water/CO-NH group" of synthetic amorphous polyamides, and it can suggest that the hydration of elastin is interpretable on the basis of a similar model.	Water	68-73	elastin	Homo sapiens	163-170
868663-6	1977	The ratio "bound water/elastin residue" is larger for the soluble beta elastin.	Water	17-22	elastin	Homo sapiens	71-78
600956-1	1977	In two dialysis centres in the same city, with a total of 56 patients on regular dialysis treatment, it has been shown that the tap water used for the production of the dialysate contains chloramines.	Water	132-137	nuclear RNA export factor 1	Homo sapiens	128-131
1005927-4	1976	Intraduodenal application of tap water amounting to 0.5, 1,0 or 2,0% body weight lead to extremely variable reactions both in time course and dimension of AVD.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
1069756-2	1976	A 1:1 water-paste slurry of a placebo and several experimental dentifrices was swabbed daily for six weeks on the teeth of albino rats, and the plaque collected on the teeth was measured in vivo first before the treatments began and one, two, three, and six weeks after.	Water	6-11	selectin L	Rattus norvegicus	0-5
10841-0	1976	Organic flocculation: an efficient second-step concentration method for the detection of viruses in tap water.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
1035190-10	1976	NSP had antiulcerogenic effects on Takagi"s restraint-plus-water-immersing ulcers in rats and histamine-induced duodenal ulcers in guinea pigs, but no influence on Shay ulcers in Wistar rats.	Water	59-64	reticulon 1	Rattus norvegicus	0-3
959032-0	1976	[Bitter salt spring water from the Inowroclaw Spa in the form of effervescent tablets].	Water	20-25	surfactant protein A2	Homo sapiens	46-49
59074-1	1976	Blood and tap-water lead levels were examined in 135 hypertensives and 135 age and sex matched normotensives.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
59074-3	1976	A positive correlation was found between blood-lead and tap-water lead.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
932786-1	1976	An assay of water content and specific gravity in normal and pathological autopsy brain has been correlated with CCT attenuation values obtained just prior to brain cutting.	Water	12-17	CCT	Homo sapiens	113-116
932786-3	1976	Low attenuation values in CCT correlate better with changes in specific gravity, rather than water in infarcts, but they have a close relationship to water content in edema.	Water	150-155	CCT	Homo sapiens	26-29
181078-0	1976	The spin-lattice relaxation times of water associated with early post mortem changes in skeletal muscle.	Water	37-42	spindlin 1	Homo sapiens	4-8
181078-1	1976	We studied the spin-echo signal of muscle water in a large time domain and found that the motion of the nuclear magnetic moment of tissue water cannot be characterized by a single spin-lattice relaxation time (T1).	Water	42-47	spindlin 1	Homo sapiens	15-19
181078-1	1976	We studied the spin-echo signal of muscle water in a large time domain and found that the motion of the nuclear magnetic moment of tissue water cannot be characterized by a single spin-lattice relaxation time (T1).	Water	138-143	spindlin 1	Homo sapiens	15-19
181078-1	1976	We studied the spin-echo signal of muscle water in a large time domain and found that the motion of the nuclear magnetic moment of tissue water cannot be characterized by a single spin-lattice relaxation time (T1).	Water	138-143	spindlin 1	Homo sapiens	180-184
1067489-4	1976	Dialysate calcium ranged between 5.7 and 7.3 mg/100 ml depending on the calcium content of local tap water.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
5917-0	1976	Atomic-absorption determination of vanadium and molybdenum in tap water and mineral waters after anion-exchange separation.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
1254680-2	1976	This procedure has allowed for the analysis of volatile organics in the low parts-per-billion range from 1 liter or less of tap water.	Water	128-133	nuclear RNA export factor 1	Homo sapiens	124-127
1262774-2	1976	Data are presented for the factors which govern the adherence to the skin and the range of initial impedance and the values obtained at 2, 5, 10 and 20 minutes and with tap water under the electrodes.	Water	173-178	nuclear RNA export factor 1	Homo sapiens	169-172
1262774-4	1976	Tap water placed under the electrodes dramatically reduces the initial range of impedance.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
59648-2	1976	The Hartley guinea-pig has been shown consistently to form antibody to ox insulin, when given in a water-in-oil emulsion containing pertussis vaccine as adjuvant.	Water	99-104	insulin	Cavia porcellus	74-81
59418-2	1976	Preliminary dissolution in tap water proved impractical.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
4337928-2	1972	Improvement of methodology and application to tap water.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
4679882-0	1972	Hemolysis in dialyzed patients: tap water-induced red blood cell metabolic deficiency.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
4942838-0	1971	[Demand for the introduction and sale of natural mineral water in France from the so-called "de la Reine" spring at Spa (Belgium)].	Water	57-62	surfactant protein A2	Homo sapiens	116-119
4324193-5	1971	When tap water was sampled, the amounts of virus adsorbed by the gauze pads were very small, about 2% of the total number of virus particles flowing through the device.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	5-8
4324193-7	1971	Addition of NaCl to tap water produced a much better effect on virus adsorption and recovery by this device, i.e., 47% of the total virus particles in each sample.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
5483169-0	1970	Effect of Ca2+ on the water and non-electrolyte permeability of phospholipid membranes.	Water	22-27	carbonic anhydrase 2	Homo sapiens	10-13
5447535-1	1970	The removal of ozone from the air by bean leaves is regulated by the same factors that control the exchange of water vapor between leaves and the atmosphere.	Water	111-116	brain expressed associated with NEDD4 1	Homo sapiens	37-41
5354767-0	1969	Action of pancreatic lipase on emulsions of water-solubl esters.	Water	44-49	pancreatic lipase	Homo sapiens	10-27
5386192-2	1969	The hydrolysis of monolayers of phosphatidyl[Me-(14)C]choline at the air/water interface by phospholipase D (phosphatidylcholine phosphatidohydrolase) was investigated by a surface-radioactivity technique by using a flow counter.	Water	73-78	phospholipase D	Saccharomyces cerevisiae S288C	92-107
31824076-1	1968	Mixing of aqueous polymer solutions containing Ti3+ and H2O2 in a rapid flow mixer produced radicals by abstraction, OH + RH   R   + H2O, which were observed by electron spin resonance.	Water	56-60	spindlin 1	Homo sapiens	170-174
31824076-1	1968	Mixing of aqueous polymer solutions containing Ti3+ and H2O2 in a rapid flow mixer produced radicals by abstraction, OH + RH   R   + H2O, which were observed by electron spin resonance.	Water	56-59	spindlin 1	Homo sapiens	170-174
4160071-0	1965	Staining cells on a membrane filter with Giemsa stock and tap water.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
5857138-0	1965	[Changes in the methemoglobin concentration in cadaveric blood with special reference to poisoning with spring water].	Water	111-116	hemoglobin subunit gamma 2	Homo sapiens	16-29
19866668-4	1965	Esterase, ATPase, and glutamine synthetase were found to be present and fully functional in the microsomal fractions isolated in water.	Water	129-134	glutamate-ammonia ligase	Rattus norvegicus	22-42
5858016-2	1965	Iron bacteria in tap water and in the sediment of pipes system].	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
14155121-3	1964	A simple system is described in which cooled tap water is circulated through an extragastric reservoir, using an applicator modified slightly from the original design described by Wangensteen.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
13976365-0	1963	[Action of Uriage water on the cholinesterase activity of the blood in rabbits and man].	Water	18-23	cholinesterase	Oryctolagus cuniculus	31-45
14001827-0	1962	Conversion of oxy- to methemoglobin by impurities in distilled water.	Water	63-68	hemoglobin subunit gamma 2	Homo sapiens	22-35
13891157-0	1962	Diuretic effect of oxytocin in a patient with reversed diurnal rhythm of water and electrolyte excretion.	Water	73-78	oxytocin/neurophysin I prepropeptide	Homo sapiens	19-27
13888194-0	1961	[On the effect of mineral water from the Naftusia spring in Truskawiec spa on the blood and urine calcium content in patients with urolithiasis].	Water	26-31	surfactant protein A2	Homo sapiens	71-74
13696676-0	1961	[Action of oxytocin on the renal excretion of water, sodium and potassium].	Water	46-51	oxytocin/neurophysin I prepropeptide	Homo sapiens	11-19
13564338-0	1958	Tic douloureux: permanent cure by injection of hot water into gasserian ganglion.	Water	51-56	alcohol dehydrogenase iron containing 1	Homo sapiens	47-50
14381187-0	1955	The relief of tic douloureux (trigeminal tic) and other pains of the fifth cranial nerve by injection of hot water into the gasserian ganglion.	Water	109-114	alcohol dehydrogenase iron containing 1	Homo sapiens	105-108
17749050-0	1952	Determination of Specific Activities of Cl4-Labeled Organic Compounds with a Water-Soluble Liquid Scintillator.	Water	77-82	endogenous retrovirus group W member 3	Homo sapiens	40-43
16654266-0	1950	THE INFLUENCE OF CALCIUM ION ACTIVITY IN WATER CULTURES ON THE INTAKE OF CATIONS BY BEAN PLANTS.	Water	41-46	brain expressed associated with NEDD4 1	Homo sapiens	84-88
18139631-0	1949	[Mineral water Rudolfka of Marianske Lazne Spa and its use in acute nonspecific cystitis in women].	Water	9-14	surfactant protein A2	Homo sapiens	43-46
18139635-0	1949	[Age of the mineral water of Frantiskovy Lazne Spa and its enzymatic activity].	Water	20-25	surfactant protein A2	Homo sapiens	47-50
16654245-0	1949	RELATION OF WATER TO THE GERMINATION OF BEAN SEEDS.	Water	12-17	brain expressed associated with NEDD4 1	Homo sapiens	40-44
18152199-0	1949	Some chemical properties of Manila tap water and their relation to corrosion of the distribution system.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
1278124-6	1976	Human duodenum extract with hot water contained secretin or secretin-like material that shows a parallel displacement curve to the standard in the immunoassay system used.	Water	32-37	secretin	Homo sapiens	48-56
1278124-6	1976	Human duodenum extract with hot water contained secretin or secretin-like material that shows a parallel displacement curve to the standard in the immunoassay system used.	Water	32-37	secretin	Homo sapiens	60-68
18871880-1	1948	Tween 80 and Triton A20 are two water-dispersible, non-ionic, surface-active agents which favor dispersed growth of tubercle bacilli in aqueous media probably by wetting the bacterial surface.	Water	32-37	immunoglobulin kappa variable 1-27	Homo sapiens	20-23
18064629-6	2008	All-trans retinoic acid or atRA, while alone inducing AQP3 expression, attenuates UV-induced down-regulation of AQP3 and water permeability.	Water	121-126	aquaporin 3 (Gill blood group)	Homo sapiens	54-58
18858171-0	1948	An arrangement by which a single water tap may be used to run a distillation in vacuo, a condenser, a constant-level water-bath.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	39-42
18858171-0	1948	An arrangement by which a single water tap may be used to run a distillation in vacuo, a condenser, a constant-level water-bath.	Water	117-122	nuclear RNA export factor 1	Homo sapiens	39-42
18064629-8	2008	Using specific AQP3"s water transport inhibitors and siRNA knockdown, we observe that AQP3 is involved in cell migration and in vitro wound healing.	Water	22-27	aquaporin 3 (Gill blood group)	Homo sapiens	15-19
19993665-16	1947	(c) When the whole cable is wound around the vessel, the concentration of the electrolyte becomes the factor determining the way in which the energy will be dissipated: (1) with tap-water, it is found that no eddy currents can be demonstrated whereas coaxial currents exist; (2) with strong saline solutions the converse holds good; (3) with electrolytes of intermediate concentration both types of currents can be shown to coexist at the periphery while at the centre only coaxial currents can be demonstrated.The fact that eddy currents and coaxial currents could be detected simultaneously and did not, as might be expected, give rise to a resultant, could only be explained by assuming that although eddy currents and coaxial currents coexisted as far as their effects on the pilot lamp were concerned, these two phenomena were not coincident as regards their phase relations.	Water	182-187	nuclear RNA export factor 1	Homo sapiens	178-181
1392-2	1976	The pH dependence of the p-hydroxymercuribenzoate-induced difference spectrum can be accounted for quantitatively by a 5% shift toward higher spin of the aquo form of methemoglobin, a 15% shift toward higher spin of the hydroxide form, and a shift in the apparent pKa for the water to hydroxide transition from 7.92 to 8.04 when mercurial is bound.	Water	276-281	hemoglobin subunit gamma 2	Homo sapiens	167-180
18064629-8	2008	Using specific AQP3"s water transport inhibitors and siRNA knockdown, we observe that AQP3 is involved in cell migration and in vitro wound healing.	Water	22-27	aquaporin 3 (Gill blood group)	Homo sapiens	86-90
18064629-9	2008	UV-induced AQP3 down-regulation results in reduced water permeability, decreased cell migration, and delayed wound healing, which are attenuated by atRA pretreatment.	Water	51-56	aquaporin 3 (Gill blood group)	Homo sapiens	11-15
18424595-6	2008	Ferritin-iron was no longer detectable after boiling the legumes for 50 min in excess water.	Water	86-91	ferritin-1, chloroplastic	Glycine max	0-8
1084678-1	1976	Cat submaxillary kallikrein was purified from the water extract of the gland by 50-75% acetone fractionation, DEAE-Sephadex A-50 chromatography, Sephadex G-75 gel filtration and Ampholine isoelectric focusing.	Water	50-55	kallikrein related peptidase 4	Homo sapiens	17-27
33571763-0	2021	New methods based on back propagation (BP) and radial basis function (RBF) artificial neural networks (ANNs) for predicting the occurrence of haloketones in tap water.	Water	161-166	nuclear RNA export factor 1	Homo sapiens	157-160
18504185-0	2008	[Role of AQP-4 in pulmonary water metabolism in rats in early stage of oleic acid-induced acute lung injury].	Water	28-33	aquaporin 4	Rattus norvegicus	9-14
33676917-2	2021	The glymphatic system is a recently identified waste clearance pathway in the brain, found in the paravascular space and mainly composed of astrocytes and their aquaporin-4 (AQP4) water channels.	Water	180-185	aquaporin 4	Homo sapiens	161-172
33676917-2	2021	The glymphatic system is a recently identified waste clearance pathway in the brain, found in the paravascular space and mainly composed of astrocytes and their aquaporin-4 (AQP4) water channels.	Water	180-185	aquaporin 4	Homo sapiens	174-178
1052778-0	1976	A re-examination of the conformation of secretin in water.	Water	52-57	secretin	Homo sapiens	40-48
1191633-8	1975	Hence, the NMR data support the view that water-swollen elastin is composed of a network of mobile chains, except possibly in the cross-link regions.	Water	42-47	elastin	Homo sapiens	56-63
33431266-2	2021	NMOSD is an astrocytic channelopathy involving the aquaporin-4 (AQP4) water channels in the central nervous system.	Water	70-75	aquaporin 4	Homo sapiens	51-62
18468451-2	2008	Increased distal tubule sodium and water reabsorption through the epithelial sodium channel (ENaC) and aquaporin-2 (AQP-2) have been suggested to play mechanistic roles.	Water	35-40	aquaporin 2	Rattus norvegicus	103-114
33431266-2	2021	NMOSD is an astrocytic channelopathy involving the aquaporin-4 (AQP4) water channels in the central nervous system.	Water	70-75	aquaporin 4	Homo sapiens	64-68
1191650-1	1975	The unstirred water layer has been shown to lead to an underestimation of apparent Km (Km(app)) values for active transport processes in intestinal whole tissue preparations.	Water	14-19	amyloid beta precursor protein	Rattus norvegicus	87-94
34043319-5	2021	Notably, SAA with different DSs exhibited various glass transition temperatures (109-140  C), and SAA with high DS (>0.84) was insoluble even after boiling in water for 1 h. Also, the maximum fracture strength of SAA film up to 15.5 MPa and a maximum elongation at break up to 30% were reached .	Water	159-164	serum amyloid A1 cluster	Homo sapiens	98-101
18468451-2	2008	Increased distal tubule sodium and water reabsorption through the epithelial sodium channel (ENaC) and aquaporin-2 (AQP-2) have been suggested to play mechanistic roles.	Water	35-40	aquaporin 2	Rattus norvegicus	116-121
34043319-5	2021	Notably, SAA with different DSs exhibited various glass transition temperatures (109-140  C), and SAA with high DS (>0.84) was insoluble even after boiling in water for 1 h. Also, the maximum fracture strength of SAA film up to 15.5 MPa and a maximum elongation at break up to 30% were reached .	Water	159-164	serum amyloid A1 cluster	Homo sapiens	98-101
2016-2	1975	Maximal levels of free water clearance/clomerular filtration rate (CH2O/GFR) averaged 8.4% with nitrate loading and 14.4% with saline loading.	Water	23-28	Rap guanine nucleotide exchange factor 5	Homo sapiens	67-75
18519086-2	2008	When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-urine into the interstitium.	Water	140-145	aquaporin 2	Homo sapiens	121-132
1059138-1	1975	Elastin undergoes a glass transition in a temperature range depends on its water content.	Water	75-80	elastin	Homo sapiens	0-7
34038017-1	2021	In astrocytes, unknown mechanisms regulate the expression of M1 and M23 isoforms of water channel aquaporin-4 (M1-AQP4 and M23-AQP4).	Water	84-89	aquaporin 4	Mus musculus	114-118
34038017-1	2021	In astrocytes, unknown mechanisms regulate the expression of M1 and M23 isoforms of water channel aquaporin-4 (M1-AQP4 and M23-AQP4).	Water	84-89	aquaporin 4	Mus musculus	127-131
18519086-2	2008	When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-urine into the interstitium.	Water	140-145	aquaporin 2	Homo sapiens	134-138
34033479-7	2021	Strong correlations between concentrations of gas-phase NCl3 with concentrations of CO2 and water (relative humidity) were found and attributed to similar features in their physical transport processes in pool air.	Water	92-97	calpain 5	Homo sapiens	56-60
18519086-2	2008	When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-urine into the interstitium.	Water	217-222	aquaporin 2	Homo sapiens	121-132
18519086-2	2008	When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-urine into the interstitium.	Water	217-222	aquaporin 2	Homo sapiens	134-138
18519086-3	2008	The essential role of the vasopressin V2 receptor and AQP2 in the maintenance of body water homeostasis became clear when it was shown that mutations in their genes cause nephrogenic diabetes insipidus, a disorder in which the kidney is unable to concentrate urine in response to AVP.	Water	86-91	aquaporin 2	Homo sapiens	54-58
34028282-9	2021	The internal temperature is estimated from the breakdown diagram associated with the dissociative ionization of the water dimer to be around to 130 K. This analysis also provides two additional, independently measured values for the 0 K appearance energy of the hydronium ion (H3O+) from dissociative ionization of the water dimer.	Water	116-121	H3 clustered histone 15	Homo sapiens	277-280
34028282-9	2021	The internal temperature is estimated from the breakdown diagram associated with the dissociative ionization of the water dimer to be around to 130 K. This analysis also provides two additional, independently measured values for the 0 K appearance energy of the hydronium ion (H3O+) from dissociative ionization of the water dimer.	Water	319-324	H3 clustered histone 15	Homo sapiens	277-280
1084038-4	1975	Almost 50% were treated with +7 cm H2O CPAP (mean duration 32 h).	Water	35-38	centromere protein J	Homo sapiens	39-43
18519087-2	2008	This highly regulated process relies largely on vasopressin (VP) action and on the VP-sensitive water channel (AQP2) that is expressed in principal cells of the kidney collecting duct.	Water	96-101	aquaporin 2	Homo sapiens	111-115
18519089-2	2008	The mechanisms for these defects predominantly involve the nonosmotic stimulation of arginine vasopressin release with up-regulation of aquaporin 2 water channel expression and trafficking to the apical membrane of the principal cells of the collecting duct.	Water	148-153	aquaporin 2	Homo sapiens	136-147
18519090-3	2008	Specifically, this review discusses the relationship between hypercalciuria and impaired aquaporin 2-mediated water handling in both acquired and inherited disorders characterized by hypercalciuria, including those affecting the sensor of extracellular calcium concentration, the calcium-sensing receptor, which represents the principal target for extracellular calcium regulation of several tissues including parathyroid glands and kidney.	Water	110-115	aquaporin 2	Homo sapiens	89-100
1140194-5	1975	Addition of heavy water to the perfusion fluid resulted in labelling at C-3 of lithocholic acid formed from 3-oxo-5beta-cholanoic acid, and at C-3, C-4 and C-5 of 3alpha-hydroxy-5alpha-cholanoic acid formed from 3-oxo-4-cholenoic acid.	Water	18-23	complement C3	Rattus norvegicus	72-75
34023824-11	2021	CONCLUSIONS: Imaging of water at the surrounding epidural space of high cervical level is a typical feature of dural rupture on both MRI and CT. CT-guided EBP is safe and efficient for the high-level cervical CSF leakage, especially for cases in which conservative treatments failed.	Water	24-29	EBP cholestenol delta-isomerase	Homo sapiens	155-158
1140194-5	1975	Addition of heavy water to the perfusion fluid resulted in labelling at C-3 of lithocholic acid formed from 3-oxo-5beta-cholanoic acid, and at C-3, C-4 and C-5 of 3alpha-hydroxy-5alpha-cholanoic acid formed from 3-oxo-4-cholenoic acid.	Water	18-23	complement C3	Rattus norvegicus	143-151
18487486-3	2008	The aquaporin (AQP) family of membrane water-channel proteins, especially AQP-4, is important in the regulation of water balance in the brain and facilitates reabsorption of excess fluid.	Water	39-44	aquaporin 4	Rattus norvegicus	74-79
1055449-0	1975	[Dental health from the water tap? Drinking water fluoridation not illegal any more].	Water	24-29	nuclear RNA export factor 1	Homo sapiens	30-34
1057266-0	1975	[Water Pik--a supplement to oral hygiene?	Water	1-6	EGF like, fibronectin type III and laminin G domains	Homo sapiens	7-13
33904565-3	2021	The computational analysis for H2O, OH and H and experimentally in aqueous KOH endow considerable shift in Fermi levels for Ni (111) unlike for NiF2 (110) on account of an effective coalition of p-orbitals of fluorine and d-orbitals of Ni in NiF2, NiF2 under pinning the reduced overpotential of 172 mV at 10 mA cm-2 compared to Ni (242 mV) in same electrolyte.	Water	31-34	zinc finger protein 335	Homo sapiens	242-246
33904565-3	2021	The computational analysis for H2O, OH and H and experimentally in aqueous KOH endow considerable shift in Fermi levels for Ni (111) unlike for NiF2 (110) on account of an effective coalition of p-orbitals of fluorine and d-orbitals of Ni in NiF2, NiF2 under pinning the reduced overpotential of 172 mV at 10 mA cm-2 compared to Ni (242 mV) in same electrolyte.	Water	31-34	zinc finger protein 335	Homo sapiens	242-246
18364552-2	2008	In this work, a MC model for the NACP-02 plane-parallel ionization chamber was built and validated against megavoltage electron backscatter experiments using materials of water, graphite, aluminium and copper.	Water	171-176	synuclein alpha	Homo sapiens	33-37
34019924-9	2021	Therefore, it is crucial to note that the resultant low-cost MLNR/AAc-BiFeO3 hydrogel composite in this study offers excellent potential for water and wastewater treatment applications with improved recyclability and recovery.	Water	141-146	glycine-N-acyltransferase	Homo sapiens	66-69
1220990-4	1975	The conflicting results of different authors concerning the effect of secretin on net water movement and solute absorption may be due to differences in experimental techniques, different, mostly pharmacological doses of the hormone, and a diverse response of heterogeneous species.	Water	86-91	secretin	Rattus norvegicus	70-78
18275841-1	2008	The influence of charged phospholipid membranes on the conformational state of the water-soluble fragment of cytochrome b5 has been investigated by a variety of techniques at neutral pH.	Water	83-88	cytochrome b5 type A	Homo sapiens	109-122
4528731-3	1974	Also accompanying water stress was a sharp increase in activity of acid phosphatase [orthophosphoric-monoester phosphohydrolase (acid optimum), EC 3.1.3.2], and acid and alkaline lipase [glycerol ester hydrolase EC 3.1.1.3] within chloroplasts.	Water	18-23	GDSL esterase/lipase At5g18430-like	Gossypium hirsutum	179-185
34002021-5	2021	We observe that both KIDINS220 and the water channel aquaporin-4 (AQP4) are markedly downregulated at the ventricular ependymal lining of idiopathic normal pressure hydrocephalus (iNPH) patients.	Water	39-44	aquaporin 4	Homo sapiens	66-70
33983359-4	2021	The subsequent near infrared (NIR) light irradiation at 980 nm or visible light irradiation at 470 nm can initiate dissociation of the spc ligand, and the released Ru(ii) aqua compounds ([Ru(dip)2(H2O)2]2+) may exert a potent cytotoxicity towards a series of cancer cells but a much weaker effect on the normal IOSE80 cells.	Water	197-200	disco interacting protein 2 homolog A	Homo sapiens	188-196
18311969-5	2008	It is found that the binding of the methylated lysine substrate in the active site of SET7/ 9 opens up the cofactor AdoMet binding channel so that solvent water molecules get access to the active site.	Water	155-160	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	86-93
33965388-12	2021	Multivariable linear regression was used to model associations of water TTHM levels with log-transformed cervicovaginal beta-defensin-2 levels.	Water	66-71	defensin beta 4B	Homo sapiens	120-135
33965388-17	2021	Counter to our hypothesis, we observed positive associations of water TTHM with log-transformed cervicovaginal beta-defensin-2 levels in unadjusted models (beta 0.20 [95%CI: 0.02, 0.39)] per SD increment of TTHM), but the association was null after adjustment for season.	Water	64-69	defensin beta 4B	Homo sapiens	111-126
18180152-1	2008	Porous nano-granule of zirconium uridine monophosphate, Zr(UMP)2.H2O is, for the first time, synthesized under mild experimental conditions and applied to the bioconjugation of myoglobin (Mb) to realize its direct electron transfer.	Water	65-68	myoglobin	Homo sapiens	177-186
34025370-8	2021	In the other (control) session, they received tap water labeled as tap water.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	67-70
34025370-8	2021	In the other (control) session, they received tap water labeled as tap water.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
4365759-2	1974	The ghosts or liposomes are loaded with a concentrated solution of a water-soluble, membrane-impermeable spin label, so that there is a strong exchange broadening of the paramagnetic resonance signal due to labels enclosed within the liposomes or ghosts.	Water	69-74	spindlin 1	Homo sapiens	105-109
4131274-3	1974	The glutamate decarboxylase was made visible on sections by means of the product formed by the action of peroxidase on 3,3"-diaminobenzidine and H(2)O(2).	Water	145-150	glutamate-ammonia ligase	Rattus norvegicus	4-27
18218985-9	2008	Finally, PIAS1 knockdown reversed the inhibitory effect of H(2)O(2) in shear stress-induced Kruppel-like factor 2 and endothelial nitric oxide synthase expression.	Water	59-64	nitric oxide synthase 3, endothelial cell	Mus musculus	118-151
4366347-0	1974	Lanthanum inhibition of the action of oxytocin on the water permeability of the frog urinary bladder: effect on the serosal and the apical membrane.	Water	54-59	oxytocin/neurophysin I prepropeptide	Homo sapiens	38-46
33582435-3	2021	During the heating process, the hydrogen bonding between side chain in P(NiPAAm-co-AAc) copolymer hydrogel and H2O was broken first, and then the formation of the intramolecular interaction in P(NiPAAm-co-AAc) copolymer hydrogel occurred.	Water	111-114	glycine-N-acyltransferase	Homo sapiens	83-86
33582435-3	2021	During the heating process, the hydrogen bonding between side chain in P(NiPAAm-co-AAc) copolymer hydrogel and H2O was broken first, and then the formation of the intramolecular interaction in P(NiPAAm-co-AAc) copolymer hydrogel occurred.	Water	111-114	glycine-N-acyltransferase	Homo sapiens	205-208
4802141-0	1973	[Behavior of the urinary excretion of kallikrein in normal subjects after oral water overloading].	Water	79-84	kallikrein related peptidase 4	Homo sapiens	38-48
18292864-2	2008	The geometries of the CF4-H2O complexes were optimized in two steps at the MP2/aug-cc-pVTZ level of theory.	Water	26-29	tryptase pseudogene 1	Homo sapiens	75-78
4351177-1	1973	The acyl chain of spin-labeled fatty acids intercalates between the lipid hydrocarbon chains in hexagonal and micellar phases with the carboxyl group anchored at the lipid water interface.	Water	172-177	spindlin 1	Homo sapiens	18-22
33129864-1	2021	BACKGROUND: Between 1968 and 1983, public drinking water supplies of Cape Cod, Massachusetts were contaminated with the chlorinated solvent tetrachloroethylene (PCE).	Water	51-56	structural maintenance of chromosomes 2	Homo sapiens	69-73
33585670-3	2021	However, water overuse during hand scrubbing with soap keeping the tap on may put enormous pressure on the already overstretched groundwater resources and households" economic well-being.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	67-70
18260647-2	2008	After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+).	Water	116-121	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	23-29
33585670-4	2021	Therefore, this study aimed to determine the overuse of water while scrubbing hands with soap for handwashing when the tap is on amid the COVID-19 pandemic in Bangladesh.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	119-122
33585670-8	2021	A single participant, who kept his tap on throughout the handwashing process, overused approximately 1.7L of water per handwash and 14.9L of water per day.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	35-38
33585670-8	2021	A single participant, who kept his tap on throughout the handwashing process, overused approximately 1.7L of water per handwash and 14.9L of water per day.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	35-38
4683857-0	1973	Effect of secretin and cholecystokinin on the transport of electrolyte and water in human jejunum.	Water	75-80	secretin	Homo sapiens	10-18
18260647-2	2008	After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+).	Water	180-185	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	23-29
4512087-0	1973	A study on the corrosivity of the tap water in central Taiwan.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
33585670-9	2021	Hand scrubbing with soap keeping the tap on, raised the overuse of water 13-fold during this pandemic compared to the non-pandemic situation which cost an extra 224.95 BDT (2.65$) per day for 1980 participants.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	37-40
33585670-10	2021	Minimize the speed of tap, using automatic taps, and using taps operated by legs might be an effective solution to reduce the water overuse.	Water	126-131	nuclear RNA export factor 1	Homo sapiens	22-25
17714957-16	2008	Crosslinks also contribute to the ability to hold water and to the resistance against degradation by MMP-1.	Water	50-55	interstitial collagenase	Bos taurus	101-106
33600050-6	2021	Molecular Dynamics simulations performed on a ClC-5 homology model demonstrated that such mutations may alter ClC-5 protonation by interfering with the water pathway.	Water	152-157	chloride voltage-gated channel 5	Homo sapiens	46-51
33600050-6	2021	Molecular Dynamics simulations performed on a ClC-5 homology model demonstrated that such mutations may alter ClC-5 protonation by interfering with the water pathway.	Water	152-157	chloride voltage-gated channel 5	Homo sapiens	110-115
4509324-1	1972	Conformational energies were calculated for oxytocin in water, starting with a conformation proposed from nuclear magnetic resonance measurements in [U-(2)H](CH(3))(2)SO.	Water	56-61	oxytocin/neurophysin I prepropeptide	Homo sapiens	44-52
4350097-0	1972	[Ship drinking water disinfection using UV irradiation.	Water	15-20	inositol polyphosphate-5-phosphatase D	Homo sapiens	1-5
18237164-9	2008	Finally, molecular dynamics (MD) simulations, in the gas phase and in water, of CGPC, CGGC, and the corresponding wild-type Trx and P34G Trx show that the activity of the thioredoxin active-site motif (CXYC) is determined not only by the structural rigidity associated with the particular variable residues (XY) but also by the number of amide N-H groups.	Water	70-75	thioredoxin	Homo sapiens	171-182
33945852-1	2021	Aquaporin 4 (AQP4) is the main membrane water channel in the brain involved in regulating water homeostasis.	Water	40-45	aquaporin 4	Homo sapiens	0-11
33945852-1	2021	Aquaporin 4 (AQP4) is the main membrane water channel in the brain involved in regulating water homeostasis.	Water	40-45	aquaporin 4	Homo sapiens	13-17
18206860-10	2008	Thus, an activation of P2X7R in astrocytes in response to brain injury is likely to play a role in the protective down-regulation of AQP4, which might inhibit water influx to the cells and attenuate the acute cytotoxic brain edema after acute brain injury.	Water	159-164	aquaporin 4	Rattus norvegicus	133-137
33945852-1	2021	Aquaporin 4 (AQP4) is the main membrane water channel in the brain involved in regulating water homeostasis.	Water	90-95	aquaporin 4	Homo sapiens	0-11
33945852-1	2021	Aquaporin 4 (AQP4) is the main membrane water channel in the brain involved in regulating water homeostasis.	Water	90-95	aquaporin 4	Homo sapiens	13-17
5076790-0	1972	The determination of part-per-billion levels of citric and nitrilotriacetic acids in tap water and sewage effluents.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
17928628-7	2008	Differentially regulated genes included several encoding proteins involved in spermatozoal maturation, water and ion channels, and beta-defensins: CRISP1, SPINLW1, FAM12B, and DEFB129 were upregulated, whereas CFTR, AQP5, KCNK4, KCNK17, SLC6A20, SLC13A3, DEFB126, and DEFB106A were downregulated.	Water	103-108	cysteine rich secretory protein 1	Homo sapiens	147-153
5044048-0	1972	Rat small intestinal mucin: isolation and characterization of a water-soluble mucin fraction.	Water	64-69	solute carrier family 13 member 2	Rattus norvegicus	21-26
5044048-0	1972	Rat small intestinal mucin: isolation and characterization of a water-soluble mucin fraction.	Water	64-69	solute carrier family 13 member 2	Rattus norvegicus	78-83
18156624-6	2008	In vivo blockade of IFN-gamma and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production.	Water	67-70	interleukin 4	Mus musculus	34-38
4263457-0	1972	[The isolation of porcine and human kallikrein using affinity chromatography: specific binding to water-insoluble Kunitz soybean-inhibitor-celluloses and dissociation with competitive inhibitors (benzamidine)].	Water	98-103	kallikrein related peptidase 4	Homo sapiens	36-46
5057131-3	1972	In the absence of ADH, the osmotic (P(f), cm sec(-1)) and diffusional (P(DW) cm sec(-1)) water permeability coefficients were, respectively, 6+/-6 and 4.7+/-1.3 (SD).	Water	89-94	secretory blood group 1, pseudogene	Homo sapiens	80-87
17765283-10	2008	However, the NOM removal obtained with the NF90 and NF270 NF membranes for all water sources is almost complete (90%).	Water	79-84	interleukin enhancer binding factor 3	Homo sapiens	43-47
5066829-0	1972	Treatment of idiopathic hyperhidrosis with iontophoresis of tap water and poldine methosulphate.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
18221514-7	2008	The divergence in the dynamic properties of eEF1A1 and eEF1A2 is caused by interactions of amino acid residues that differ between the two variants with neighboring residues and water environment.	Water	178-183	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	55-61
24500096-3	1970	A further drop of the relative water content was accompanied by a strong decrease of the activity of the succinate and malate oxidase system, but only a slight decrease of succinate and malate dehydrogenase activity.	Water	31-36	malic enzyme 1	Homo sapiens	186-206
17956998-4	2008	Among the 30 transcripts with the greatest signals on the arrays were 3 water channels: aquaporin-2, aquaporin-3, and aquaporin-4, all of which have been reported to be targets for regulation by vasopressin.	Water	72-77	aquaporin 2	Rattus norvegicus	88-99
4248732-0	1970	Branchial reduction and renal stimulation of (Na+, K+)-ATPase by prolactin in hypophysectomized killifish in fresh water.	Water	115-120	prolactin	Fundulus heteroclitus	65-74
17956998-4	2008	Among the 30 transcripts with the greatest signals on the arrays were 3 water channels: aquaporin-2, aquaporin-3, and aquaporin-4, all of which have been reported to be targets for regulation by vasopressin.	Water	72-77	aquaporin 3 (Gill blood group)	Rattus norvegicus	101-112
17746032-2	1970	Potential applications include production of potable water from brackish sources or of highly purified water from tap water.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	114-117
17956998-4	2008	Among the 30 transcripts with the greatest signals on the arrays were 3 water channels: aquaporin-2, aquaporin-3, and aquaporin-4, all of which have been reported to be targets for regulation by vasopressin.	Water	72-77	aquaporin 4	Rattus norvegicus	118-129
17890385-1	2008	Aquaporin-1 (AQP1) is an integral membrane protein that facilitates osmotic water transport across cell plasma membranes in epithelia and endothelia.	Water	76-81	aquaporin-1	Canis lupus familiaris	0-11
5505285-0	1970	[Effects of tritox contained in water on the activity of serum cholinesterase in rats].	Water	32-37	butyrylcholinesterase	Rattus norvegicus	63-77
17890385-1	2008	Aquaporin-1 (AQP1) is an integral membrane protein that facilitates osmotic water transport across cell plasma membranes in epithelia and endothelia.	Water	76-81	aquaporin-1	Canis lupus familiaris	13-17
5400935-0	1969	[On the use of the absorption-elution method in identification of water-soluble ABH group-specific substances.	Water	66-71	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	80-83
19096118-3	2008	PureSorb-Q40 (P40) (Water-soluble type CoQ10 powder, CoQ10 content 40 w/w % was developed in order to improve its use with food products and to enhance its absorption.	Water	20-25	septin 3	Rattus norvegicus	14-17
5401717-0	1969	[On use of the absorption-elution method in the identification of water-soluble ABH group-specific substances.	Water	66-71	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	80-83
20305732-3	2008	Glutathione S-transferases (GSTs) primary function is to detoxify carcinogens by increasing their water solubility, GSTs represent key carcinogen metabolizing enzymes.	Water	98-103	glutathione S-transferase kappa 1	Homo sapiens	0-26
5198048-0	1969	Radiostrontium in milk and tap water.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
20305732-3	2008	Glutathione S-transferases (GSTs) primary function is to detoxify carcinogens by increasing their water solubility, GSTs represent key carcinogen metabolizing enzymes.	Water	98-103	glutathione S-transferase kappa 1	Homo sapiens	28-32
5187196-0	1967	Radiostrontium in milk and tap water.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
20305732-3	2008	Glutathione S-transferases (GSTs) primary function is to detoxify carcinogens by increasing their water solubility, GSTs represent key carcinogen metabolizing enzymes.	Water	98-103	glutathione S-transferase kappa 1	Homo sapiens	116-120
17741146-1	1967	A radio-controlled model boat obtained surface samples of plankton and of air over water; it was especially useful in obtaining samples of neuston in water less than 15 centimeters in depth.	Water	83-88	ataxin 1 like	Homo sapiens	25-29
18028419-5	2008	Growth inhibition was measured using the water-soluble tetrazolium salt 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST-1 assay), and apoptosis was determined by flow cytometry after staining with fluorescein isothiocyanate-labeled annexin V (annexin-V-FITC) and propidium iodide.	Water	41-46	annexin A5	Homo sapiens	268-277
18680141-4	2008	Compared with the swimming only group and holding-box group, agmatine levels were significantly increased in the CA1 and dentate gyrus subregions of the hippocampus, the entorhinal cortex and the vestibular nucleus in the water-maze training group.	Water	222-227	carbonic anhydrase 1	Rattus norvegicus	113-116
5584695-0	1967	[Thermo-stability of water-soluble ABH antigens in the saliva].	Water	21-26	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	35-38
17360101-1	2008	The sorption of aqueous lead on carbonate-hydroxyapatite (CHAp) is a complicated non-homogeneous solid/water reaction, which from the kinetic point of view has two stages.	Water	103-108	transcription factor like 5	Homo sapiens	58-62
5993394-0	1966	[To the problem of apyrogenicity of demineralized water obtained from tap-water by means of the ion exchange method].	Water	50-55	nuclear RNA export factor 1	Homo sapiens	70-73
5993394-0	1966	[To the problem of apyrogenicity of demineralized water obtained from tap-water by means of the ion exchange method].	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
18052136-2	2007	The Morokuma decomposition scheme of ab initio interaction energies at the SCF level and the dispersion component at the MP2 level were used to reproduce the molecular parameters of the solute-water interaction potentials.	Water	193-198	tryptase pseudogene 1	Homo sapiens	121-124
5909313-0	1966	Effects of acute and chronic inhibition of cholinesterase upon body weight, food intake, and water intake in the rat.	Water	93-98	butyrylcholinesterase	Rattus norvegicus	43-57
18044969-0	2007	Histone lysine methyltransferase SET7/9: formation of a water channel precedes each methyl transfer.	Water	56-61	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	33-39
5988163-0	1966	[An ionite method for obtaining desalted apyrogenic water from tap water].	Water	52-57	nuclear RNA export factor 1	Homo sapiens	63-66
5988163-0	1966	[An ionite method for obtaining desalted apyrogenic water from tap water].	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
17878057-4	2007	in either a baseline condition or following exposure to 1% acetone in drinking water to induce CYP2E1 expression.	Water	79-84	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	95-101
14288885-0	1965	[INHIBITION BY WATER-SOLUBLE STEROIDS OF THE UTERINE ACTION OF OXYTOCIN].	Water	15-20	oxytocin/neurophysin I prepropeptide	Homo sapiens	63-71
20442481-0	2007	Enhanced solar water-splitting efficiency using core/sheath heterostructure CdS/TiO2 nanotube arrays.	Water	15-20	CDP-diacylglycerol synthase 1	Homo sapiens	76-79
14298065-0	1965	[ON THE USE OF BATHS IN DILUTE MINERAL WATER FROM ARZNI SPA IN THE TREATMENT OF CORONARY DISEASE IN HYPERTENSIVE PATIENTS].	Water	39-44	surfactant protein A2	Homo sapiens	56-59
20442481-5	2007	We demonstrate that ac deposition voltage and time can control the CdS/TiO(2) composite architecture, which is crucial in determining the overall efficiency of the water-splitting reaction.	Water	164-169	CDP-diacylglycerol synthase 1	Homo sapiens	67-70
13998499-1	1963	Estimates of daily total fluid intake and of tap-water consumption of normal children were made in four dissimilar geographic areas in the United States.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
18086773-4	2007	In humans, fecal water samples collected from feces of free-living volunteers showed that 24-h exposure to 1% dilution of fecal water produced a significant 2.6-, 6.5-, 7.5-, and 2.2-fold increase in Mn-BN, Npb-BN, BN cells with nuclear buds, and necrotic cells compared with controls (P &lt; 0.05).	Water	128-133	neuropeptide B	Homo sapiens	207-210
13998499-2	1963	(Total fluid intake increased and, relatively speaking, tap-water consumption decreased, with age.)	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
13998499-3	1963	Of basic importance in fluoridation programs was the observation that even older children rarely drank as much as 500 ml (about 1 pint) of tap water daily.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
13899861-0	1962	Coco-nut water for intravenous therapy.	Water	9-14	DAN domain BMP antagonist family member 5	Homo sapiens	0-4
17991030-1	2007	The Black Sea is the largest anoxic water basin on Earth and its stratified water column comprises an upper oxic, middle suboxic and a lower permanently anoxic, sulfidic zone.	Water	36-41	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	10-13
13838166-0	1960	The effect of oxytocin and vasopressin and of phenylalanyl 3-oxytocin on the urinary excretion of water and electrovtes.	Water	98-103	oxytocin/neurophysin I prepropeptide	Homo sapiens	61-69
33858656-1	2021	Aquaporin-4 (AQP4) is a predominant water channel in the central nervous system.	Water	36-41	aquaporin 4	Mus musculus	0-11
33858656-1	2021	Aquaporin-4 (AQP4) is a predominant water channel in the central nervous system.	Water	36-41	aquaporin 4	Mus musculus	13-17
17991030-1	2007	The Black Sea is the largest anoxic water basin on Earth and its stratified water column comprises an upper oxic, middle suboxic and a lower permanently anoxic, sulfidic zone.	Water	76-81	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	10-13
13747444-0	1960	[Studies on the stoichiometry and structure of water- or alcohol compounds of protoporphyrin, hemin and methemoglobin].	Water	47-52	hemoglobin subunit gamma 2	Homo sapiens	104-117
33636642-1	2021	Ship ballast water can transfer harmful organisms, including antibiotic-resistant bacteria (ARB), among geographically isolated waters.	Water	13-18	inositol polyphosphate-5-phosphatase D	Homo sapiens	0-4
18290421-2	2007	Through the observing system of water inherent optical properties, which were developed by WETlabs Inc, the backscattering and scattering coefficients of Lake Taihu had been obtained in Oct.	Water	32-37	plexin A2	Homo sapiens	186-189
33636642-3	2021	ARB were detected in 83.3% of the ship"s ballast water samples.	Water	49-54	inositol polyphosphate-5-phosphatase D	Homo sapiens	34-38
32826068-2	2021	Approximately 75% of patients have antibodies against aquaporin-4, a water channel expressed on astrocytes.	Water	69-74	aquaporin 4	Homo sapiens	54-65
13483162-0	1957	Removal of CBR contaminants from water.	Water	33-38	carbonyl reductase 1	Homo sapiens	11-14
17878572-0	2007	Water quality assessment of Lebanese coastal rivers during dry season and pollution load into the Mediterranean Sea.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	112-115
13289457-0	1955	[Treatment of diseases of the urinary tract with mineral water from the spring Dabrowka in Szczawno-Spa].	Water	57-62	surfactant protein A2	Homo sapiens	100-103
33921966-6	2021	Gastrointestinal symptoms predominated and were associated with drinking of contaminated water like tap water or water from communal mobile water tanks, probably because of the contamination of clean water, the disruption of water sanitation, and the inability to maintain home hygiene practices.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	100-103
33921966-6	2021	Gastrointestinal symptoms predominated and were associated with drinking of contaminated water like tap water or water from communal mobile water tanks, probably because of the contamination of clean water, the disruption of water sanitation, and the inability to maintain home hygiene practices.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
33921966-6	2021	Gastrointestinal symptoms predominated and were associated with drinking of contaminated water like tap water or water from communal mobile water tanks, probably because of the contamination of clean water, the disruption of water sanitation, and the inability to maintain home hygiene practices.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
33921966-6	2021	Gastrointestinal symptoms predominated and were associated with drinking of contaminated water like tap water or water from communal mobile water tanks, probably because of the contamination of clean water, the disruption of water sanitation, and the inability to maintain home hygiene practices.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
33921966-6	2021	Gastrointestinal symptoms predominated and were associated with drinking of contaminated water like tap water or water from communal mobile water tanks, probably because of the contamination of clean water, the disruption of water sanitation, and the inability to maintain home hygiene practices.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
33921966-6	2021	Gastrointestinal symptoms predominated and were associated with drinking of contaminated water like tap water or water from communal mobile water tanks, probably because of the contamination of clean water, the disruption of water sanitation, and the inability to maintain home hygiene practices.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
13238123-0	1954	[Determination of the fluorine content of tap water by means of the aquatester].	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
17945253-2	2007	We determined the three-dimensional structure of human CLIC2 in its water-soluble form by X-ray crystallography at 1.8-A resolution from two crystal forms.	Water	68-73	chloride intracellular channel 2	Homo sapiens	55-60
33880500-7	2021	We tested the associations between posterior substantia nigra free water and uptake of striatal dopamine transporter in idiopathic REM sleep behaviour disorder.	Water	67-72	solute carrier family 6 member 3	Homo sapiens	96-116
33880500-9	2021	In addition, we observed significantly negative associations between posterior substantia nigra free-water values and dopamine transporter striatal binding ratios in the idiopathic REM sleep behaviour disorder patients.	Water	101-106	solute carrier family 6 member 3	Homo sapiens	118-138
17595065-2	2007	The structures, vibrational frequencies, and binding energies of 1, 2, and 3 water molecules with mercury-halide (HgBr2, HgBrCl, HgCl2, HgBr, and HgCl) and related mercury and halogen species (Br2, BrCl, Cl2, Cl, Hg, and Br) have been computed with second order Moller-Plesset perturbation theory (MP2) and the B3LYP density functional method.	Water	77-82	tryptase pseudogene 1	Homo sapiens	298-301
33871557-8	2021	Compared with low intakes, high intakes of plain and tap water were associated with lower odds of high BPA concentration (OR: 0.65; 99.95% CI: 0.47, 0.91 and OR: 0.70; 99.95% CI: 0.50, 0.99, respectively).	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
13101220-0	1953	[Sodium chloride water of the Lons-le-Saunier spa].	Water	17-22	surfactant protein A2	Homo sapiens	46-49
17935329-8	2007	The hydrolysis of peptide substrate shares a common mechanism both for the catalyzed reaction in human cathepsin K and for the uncatalyzed reaction in water.	Water	151-156	cathepsin K	Homo sapiens	103-114
14841620-0	1951	[Revival of a mineral water spa; mineral water of Montegut-Segla].	Water	22-27	surfactant protein A2	Homo sapiens	28-31
33567148-2	2021	Based on a rational design of dendrimers with four and eight squaraine dyes, we found that octamer bearing dyes through a sufficiently long PEG(8) linker displays >400-fold fluorescence enhancement from water to non-polar dioxane.	Water	203-208	IGF2 antisense RNA	Homo sapiens	140-146
18084713-1	2007	Time-resolved small-angle neutron scattering (TR-SANS) was employed to observe temperature-induced phase transitions from the sponge (L (3) to the lamellar ( L (alpha) phase, and vice versa, in the water-oil (n -decane)-non-ionic surfactant ( C(12)E(5) system using both bulk and film contrast.	Water	198-203	USH1 protein network component sans	Homo sapiens	49-53
33937320-2	2021	We report the light-driven CO2 reduction in water in mild conditions by artificial protein catalysts based on cytochrome b 562 and incorporating cobalt protoporphyrin IX as cofactor.	Water	44-49	mitochondrially encoded cytochrome b	Homo sapiens	110-122
14844293-0	1951	Effect of growth hormone on water metabolism in hypophysectomized dogs.	Water	28-33	somatotropin	Canis lupus familiaris	10-24
17657494-0	2007	Post- and pre-synaptic action of isotocin in the upper esophageal sphincter muscle of the eel: its role in water drinking.	Water	107-112	solute carrier family 35 member G1	Homo sapiens	0-4
14787730-0	1950	[Effect of water of Koviljace spa on the modification of vaginal flora].	Water	11-16	surfactant protein A2	Homo sapiens	30-33
17732764-0	1946	Semi-continuous Tap-water Aerator.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
33834344-2	2021	In the process of agricultural use, PEN will be scattered to the soil and water environment, which brings certain environmental safety risks.	Water	74-79	LLGL scribble cell polarity complex component 2	Danio rerio	36-39
33837446-12	2021	The identification of microplastics larger than 100 microm in size in the treated tap water indicated potential contamination from microplastics in the treatment system, particularly after the sand filtration unit.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
33837446-13	2021	The major characteristics of the microplastics found in treated tap water were similar to those found in freshwater, with 85.6% fragments, 85.1% colorless, and 47.9% made of polyethylene polymer.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
17686967-5	2007	In contrast, CYP2C9.2 uncoupled to excess water preferentially.	Water	42-47	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	13-19
33566051-7	2021	In addition, we showed and fully validated the end-structure of the one-step designed GOx/Nafion/Pd-NPs nanobiosensor as a structural model mainly composed of GOx and water molecules incorporated into the metal-polymer scaffold.	Water	167-172	hydroxyacid oxidase 1	Homo sapiens	86-89
21009088-0	1946	Semi-continuous tap-water aerator.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
19871071-4	1941	From this fraction the reactive protein separates out on dialysis against tap water.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
17914812-1	2007	K(x)H(1-x)Ni(OH2)4[Ru2(CO3)4].zH2O is a ferrimagnet (Tc = 4.3 K) formed from the reaction of K3[Ru(II/III)2(CO3)4] and Ni(II) in water.	Water	129-134	doublecortin domain containing 2	Homo sapiens	19-22
19871071-5	1941	Following removal of the alcohol-ether-soluble lipids from acute phase serum the reactive protein becomes soluble in tap water, and is no longer precipitable by traces of calcium but still retains its precipitability with the C polysaccharide.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
19872542-9	1930	Leakage around the cell is small because the wall is imbibed with tap water.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
33523638-3	2021	The results showed that the total concentration level of measured DBPs in wastewater effluents (78.3 mug/L) was higher than that in tap water (56.0 mug/L, p = 0.05), followed by surface water (8.0 mug/L, p < 0.01).	Water	136-141	nuclear RNA export factor 1	Homo sapiens	132-135
33916459-9	2021	AF4 provides relevant information with respect to static DLS and UV-Vis Spectroscopy showing that at least two populations of aggregates with different sizes between them, depending on both, the mixture time for a given matrix and type of water matrix for the same time.	Water	239-244	AF4/FMR2 family member 1	Homo sapiens	0-3
33648644-4	2021	Moreover, the biosensor was successfully employed to determine FN concentration in blind tap water samples obtaining excellent recovery percentages with a time-to-result of only 20 min without any sample pre-treatment.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
17919024-9	2007	Spectra of FEB(H(2)O) and CEB(H(2)O) single water clusters show evidence of an anti conformation in the host molecule.	Water	44-49	vesicle associated membrane protein 3	Homo sapiens	26-35
33453412-0	2021	Loss of a water-mediated network results in reduced agonist affinity in a beta2-adrenergic receptor clinical variant.	Water	10-15	adrenoceptor beta 2	Homo sapiens	74-99
16993485-0	1921	Note on the supposed identity of the water-soluble vitamin B and secretin.	Water	37-42	secretin	Homo sapiens	65-73
17898172-5	2007	Catalase (Cat), an antioxidant enzyme degrading H(2)O(2), shows an oscillating pattern of expression and activity, antiphasic to zCry1a and zPer2.	Water	48-53	catalase	Danio rerio	0-8
33711704-6	2021	AAC had surface water exchanged with an 18O labelled water and was then exposed to beta-carotene.	Water	16-21	glycine-N-acyltransferase	Homo sapiens	0-3
33711704-6	2021	AAC had surface water exchanged with an 18O labelled water and was then exposed to beta-carotene.	Water	53-58	glycine-N-acyltransferase	Homo sapiens	0-3
17898172-5	2007	Catalase (Cat), an antioxidant enzyme degrading H(2)O(2), shows an oscillating pattern of expression and activity, antiphasic to zCry1a and zPer2.	Water	48-53	catalase	Danio rerio	0-3
17898172-5	2007	Catalase (Cat), an antioxidant enzyme degrading H(2)O(2), shows an oscillating pattern of expression and activity, antiphasic to zCry1a and zPer2.	Water	48-53	period circadian clock 2	Danio rerio	140-145
17922627-4	2007	The peptide hormone arginine vasopressin vasoconstricts at the V(1A) receptor and promotes water reabsorption via the V(2) receptor in the renal collecting duct by inserting aquaporin-2 water channels into the luminal membrane.	Water	186-191	aquaporin 2	Homo sapiens	174-185
33872576-1	2021	Aquaporin-4 (AQP4) water channels and gap junction proteins (connexins) are two classes of astrocytic membrane proteins critically involved in brain water and ion homeostasis.	Water	19-24	aquaporin 4	Mus musculus	0-11
33872576-1	2021	Aquaporin-4 (AQP4) water channels and gap junction proteins (connexins) are two classes of astrocytic membrane proteins critically involved in brain water and ion homeostasis.	Water	19-24	aquaporin 4	Mus musculus	13-17
33872576-1	2021	Aquaporin-4 (AQP4) water channels and gap junction proteins (connexins) are two classes of astrocytic membrane proteins critically involved in brain water and ion homeostasis.	Water	149-154	aquaporin 4	Mus musculus	0-11
33872576-1	2021	Aquaporin-4 (AQP4) water channels and gap junction proteins (connexins) are two classes of astrocytic membrane proteins critically involved in brain water and ion homeostasis.	Water	149-154	aquaporin 4	Mus musculus	13-17
33872576-2	2021	AQP4 channels are anchored by alpha1-syntrophin to the perivascular astrocytic endfoot membrane domains where they control water flux at the blood-brain interface while connexins cluster at the lateral aspects of the astrocytic endfeet forming gap junctions that allow water and ions to dissipate through the astrocyte syncytium.	Water	123-128	aquaporin 4	Mus musculus	0-4
33872576-2	2021	AQP4 channels are anchored by alpha1-syntrophin to the perivascular astrocytic endfoot membrane domains where they control water flux at the blood-brain interface while connexins cluster at the lateral aspects of the astrocytic endfeet forming gap junctions that allow water and ions to dissipate through the astrocyte syncytium.	Water	269-274	aquaporin 4	Mus musculus	0-4
17553938-2	2007	The antidiuretic effects of AVP are initialized by binding of AVP to the type-2 vasopressin receptor (V2R) in the kidney collecting duct (CD), resulting in the exocytic insertion of aquaporin-2 (AQP-2) water channels into the apical plasma membrane.	Water	202-207	aquaporin 2	Rattus norvegicus	182-193
17553938-2	2007	The antidiuretic effects of AVP are initialized by binding of AVP to the type-2 vasopressin receptor (V2R) in the kidney collecting duct (CD), resulting in the exocytic insertion of aquaporin-2 (AQP-2) water channels into the apical plasma membrane.	Water	202-207	aquaporin 2	Rattus norvegicus	195-200
33756365-0	2021	Spin diffusion transfer difference (SDTD) NMR: An advanced method for the characterisation of water structuration within particle networks.	Water	94-99	spindlin 1	Homo sapiens	0-4
17622964-2	2007	Recent studies have shown that aquaporin-4 (AQP4), a water channel, is induced early after stroke and potentially participates in the development of brain edema.	Water	53-58	aquaporin 4	Rattus norvegicus	31-42
33962237-0	2021	Field study on the transportation characteristics of PFASs from water source to tap water.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
17622964-2	2007	Recent studies have shown that aquaporin-4 (AQP4), a water channel, is induced early after stroke and potentially participates in the development of brain edema.	Water	53-58	aquaporin 4	Rattus norvegicus	44-48
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Water	161-166	glutathione S-transferase pi 1	Homo sapiens	114-123
33985712-3	2021	The results showed that the half-life of GA3 transformation in ultrapure water was 16.1-24.6 days at pH=2.0-8.0, with the lowest half-life occurring at pH=8.0 and highest half-life occurring at pH=3.3.	Water	73-78	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	41-44
33985712-8	2021	While GA3 and its transformation products all had developmental toxicity, the predicated LC50 (96 hr) and LD50 of the main products of GA3 were much lower than those of GA3, indicating GA3 would be transformed into higher toxicity derivatives in water environments, posing a significant health risk to humans and the environment.	Water	246-251	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	6-9
33985712-8	2021	While GA3 and its transformation products all had developmental toxicity, the predicated LC50 (96 hr) and LD50 of the main products of GA3 were much lower than those of GA3, indicating GA3 would be transformed into higher toxicity derivatives in water environments, posing a significant health risk to humans and the environment.	Water	246-251	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	135-138
33985712-8	2021	While GA3 and its transformation products all had developmental toxicity, the predicated LC50 (96 hr) and LD50 of the main products of GA3 were much lower than those of GA3, indicating GA3 would be transformed into higher toxicity derivatives in water environments, posing a significant health risk to humans and the environment.	Water	246-251	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	135-138
33985712-8	2021	While GA3 and its transformation products all had developmental toxicity, the predicated LC50 (96 hr) and LD50 of the main products of GA3 were much lower than those of GA3, indicating GA3 would be transformed into higher toxicity derivatives in water environments, posing a significant health risk to humans and the environment.	Water	246-251	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	135-138
17764303-1	2007	By incorporating effective basis sets containing diffuse functions only in the interaction region of hydrogen-bonded complexes into the simple extrapolation scheme suitable for such basis sets, an accurate estimation of the MP2 basis set limit hydrogen-bonding energies of formic acid tetramer, formamide tetramer, alanine-water, phenol-water, and guanine-cytosine base pair is made with all estimates falling within 0.1-0.3 kcalmol of the reference basis set limits.	Water	323-328	tryptase pseudogene 1	Homo sapiens	224-227
17764303-1	2007	By incorporating effective basis sets containing diffuse functions only in the interaction region of hydrogen-bonded complexes into the simple extrapolation scheme suitable for such basis sets, an accurate estimation of the MP2 basis set limit hydrogen-bonding energies of formic acid tetramer, formamide tetramer, alanine-water, phenol-water, and guanine-cytosine base pair is made with all estimates falling within 0.1-0.3 kcalmol of the reference basis set limits.	Water	337-342	tryptase pseudogene 1	Homo sapiens	224-227
17560709-0	2007	A model for triple helix formation on human telomerase reverse transcriptase (hTERT) promoter and stabilization by specific interactions with the water soluble perylene derivative, DAPER.	Water	146-151	telomerase reverse transcriptase	Homo sapiens	44-76
33651262-2	2021	Glymphatic system is a fluid exchange system that relies on the polarized water channel aquaporin-4 (AQP4) at the astrocytes, accounting for the clearance of abnormal proteins and metabolites from brain tissues.	Water	74-79	aquaporin 4	Homo sapiens	101-105
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	Water	41-44	mechanistic target of rapamycin kinase	Rattus norvegicus	108-112
17560709-0	2007	A model for triple helix formation on human telomerase reverse transcriptase (hTERT) promoter and stabilization by specific interactions with the water soluble perylene derivative, DAPER.	Water	146-151	telomerase reverse transcriptase	Homo sapiens	78-83
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	Water	41-44	mechanistic target of rapamycin kinase	Rattus norvegicus	113-117
17558559-7	2007	While ARSA and ARSB are water-soluble enzymes, STS has a hydrophobic domain and is an integral membrane protein of the endoplasmic reticulum.	Water	24-29	arylsulfatase B	Homo sapiens	15-19
33909433-1	2021	The 1,4,7,10-tetrazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) aqueous complexes of AcIII with H2O, dimethyl sulfoxide (DMSO), OH-, and F- as axial ligands were studied using density functional theory.	Water	97-100	adenylate cyclase 3	Homo sapiens	86-91
17687453-1	2007	CONTEXT: Private wells that tap groundwater are largely exempt from federal drinking-water regulations, and in most states well water is not subject to much of the mandatory testing required of public water systems.	Water	38-43	filamin B	Homo sapiens	28-31
33909433-2	2021	Formation of the [AcIII(DOTA)(OH)]2- and [AcIII(DOTA)(F)]2- complexes is predicted to be significantly more favorable than that of [AcIII(DOTA)(H2O)]- and [AcIII(DOTA)(DMSO)]- because of the enhanced relative Gibbs free energies.	Water	144-147	adenylate cyclase 3	Homo sapiens	18-23
33909433-2	2021	Formation of the [AcIII(DOTA)(OH)]2- and [AcIII(DOTA)(F)]2- complexes is predicted to be significantly more favorable than that of [AcIII(DOTA)(H2O)]- and [AcIII(DOTA)(DMSO)]- because of the enhanced relative Gibbs free energies.	Water	144-147	adenylate cyclase 3	Homo sapiens	42-47
33909433-2	2021	Formation of the [AcIII(DOTA)(OH)]2- and [AcIII(DOTA)(F)]2- complexes is predicted to be significantly more favorable than that of [AcIII(DOTA)(H2O)]- and [AcIII(DOTA)(DMSO)]- because of the enhanced relative Gibbs free energies.	Water	144-147	adenylate cyclase 3	Homo sapiens	42-47
33909433-2	2021	Formation of the [AcIII(DOTA)(OH)]2- and [AcIII(DOTA)(F)]2- complexes is predicted to be significantly more favorable than that of [AcIII(DOTA)(H2O)]- and [AcIII(DOTA)(DMSO)]- because of the enhanced relative Gibbs free energies.	Water	144-147	adenylate cyclase 3	Homo sapiens	42-47
33909433-4	2021	Specifically, the [AcIII(DOTA)]- complex strongly binds to OH- and F- via covalent bonds, while the bonding to H2O and DMSO is ionic and relatively weaker.	Water	111-114	adenylate cyclase 3	Homo sapiens	19-24
17687453-9	2007	Three months after cessation of well water consumption, this child"s corrected beta-2-microglobulin level had fallen to 52 microg/mmol creatinine.	Water	37-42	beta-2-microglobulin	Homo sapiens	79-99
17652763-1	2007	PURPOSE: Cellular retinaldehyde-binding protein (CRALBP), transcribed from the RLBP1 gene, is a 36-kDa water-soluble protein with 316 amino acids found in the retinal pigment epithelium (RPE) and in retinal Muller cells.	Water	103-108	retinaldehyde binding protein 1	Homo sapiens	9-47
34034213-2	2021	Their pathophysiology dependent on humoral mediated responses caused by autoreactive IgG antibodies against aquaporin-4 water channels (AQP4-IgG) or myelin oligodendrocyte glycoprotein (MOG-IgG).	Water	120-125	aquaporin 4	Homo sapiens	108-119
17668276-4	2007	For this purpose, a strategy was pursued in which a homology model of the hH(3)R based on the crystal structure of bovine rhodopsin was generated and refined by molecular dynamics simulations in a dipalmitoylphosphatidylcholine (DPPC)/water membrane mimic before the resulting binding pocket was used for high-throughput docking using the program GOLD.	Water	235-240	histamine receptor H3	Homo sapiens	74-80
34025481-5	2021	The diurnal variation of the glymphatic circulation is dependent on the astrocytic activity and polarization of water channel protein aquaporin-4 (AQP4).	Water	112-117	aquaporin 4	Homo sapiens	134-145
34025481-5	2021	The diurnal variation of the glymphatic circulation is dependent on the astrocytic activity and polarization of water channel protein aquaporin-4 (AQP4).	Water	112-117	aquaporin 4	Homo sapiens	147-151
34025370-7	2021	The participants drank tap water that was labeled "Lourdes water" (placebo) before a 15-min resting-state scan in one session.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
17668276-4	2007	For this purpose, a strategy was pursued in which a homology model of the hH(3)R based on the crystal structure of bovine rhodopsin was generated and refined by molecular dynamics simulations in a dipalmitoylphosphatidylcholine (DPPC)/water membrane mimic before the resulting binding pocket was used for high-throughput docking using the program GOLD.	Water	235-240	rhodopsin	Bos taurus	122-131
17643114-5	2007	CatL-deficient mice are lean and have reduced levels of serum glucose and insulin but increased levels of muscle IR beta-subunits, fibronectin and glucose transporter (Glut)-4, although food/water intake and energy expenditure of these mice are no less than their wild-type littermates.	Water	191-196	cathepsin L	Mus musculus	0-4
33949874-5	2022	We describe this pathway, coined the term glymphatic system, based on its dependency on astrocytic vascular endfeet and their adluminal expression of AQP4 water channels facing towards CSF-filled perivascular spaces.	Water	155-160	aquaporin 4	Homo sapiens	150-154
33965691-6	2021	We recently demonstrated that a purified ulvan extract activates chicken heterophils and monocytes in vivo through TLR2 and TLR4 receptors when given in drinking water.	Water	162-167	toll-like receptor 2 type-1	Gallus gallus	115-119
33837999-0	2021	A Generalized Method for High-Speed Fluorination of Metal Oxides by Spark Plasma Sintering Yields Ta3 O7 F and TaO2 F with High Photocatalytic Activity for Oxygen Evolution from Water.	Water	178-183	TAO kinase 2	Homo sapiens	111-115
17631057-0	2007	Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells.	Water	33-38	C-C motif chemokine ligand 2	Homo sapiens	87-127
17631057-3	2007	In the present study, we found that the water extract of ZoaGumHwan (ZGH), a Korean herbal remedy, dose-dependently inhibited Ang II-induced U937 monocyte adhesion to human umbilical vein endothelial cells (HUVECs) and mRNA expression of MCP-1 in HUVECs and C-C chemokine receptor 2 (CCR-2) in U937 cells.	Water	40-45	C-C motif chemokine ligand 2	Homo sapiens	238-243
33673981-4	2021	The electrospraying of CURCSNPs on surface PCL/CS/CUR nanofiber resulted in the enhanced antibacterial, antioxidant, cell proliferation efficiencies and higher swelling and water vapor transition rates.	Water	173-178	PHD finger protein 1	Homo sapiens	43-49
17585849-1	2007	A dilute solution of water in a hydrophobic solvent, such as carbon tetrachloride (CCl4), presents an opportunity to study the rotational properties of water without the complicating effects of hydrogen bonds.	Water	21-26	C-C motif chemokine ligand 4	Homo sapiens	83-87
33927247-6	2021	Larger CA1 volumes were also associated with spatial learning on a Virtual Morris Water Maze task and verbal learning on the Rey Auditory Verbal Learning Test, but not recall memory.	Water	82-87	carbonic anhydrase 1	Homo sapiens	7-10
33540490-3	2021	However, for the hexameric Ac-(deltaAc5 a)6 -NHMe, the mixed H16/14 helical structure was found to be most preferred in chloroform (populated at 68 %), whereas the H14 helical structure was the most dominant conformation in water (populated at 60 %).	Water	224-229	H1.6 linker histone, cluster member	Homo sapiens	61-64
33508258-5	2021	Notably, the decreased consumption of tap water in the community was significantly associated with increased worry, but time-on-the land was not.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
17585849-1	2007	A dilute solution of water in a hydrophobic solvent, such as carbon tetrachloride (CCl4), presents an opportunity to study the rotational properties of water without the complicating effects of hydrogen bonds.	Water	152-157	C-C motif chemokine ligand 4	Homo sapiens	83-87
33923003-11	2021	With these results, we could conclude that the selection of buffaloes with wild GT haplotypes for g.11685G>A and g.11773T>C SNPs of the PRLR gene might improve the milk production traits of Egyptian water buffaloes.	Water	199-204	prolactin receptor	Bos taurus	136-140
17585849-2	2007	We report here the results of theoretical, experimental, and semiempirical studies of a 0.03 mole percent solution of water in CCl4.	Water	118-123	C-C motif chemokine ligand 4	Homo sapiens	127-131
33480461-3	2021	Acrylic acid (AAc), N-vinylpyrrolidone (NVP), and acrylamide (AAm) are copolymerized in water, yielding copolymers with UCST behavior.	Water	88-93	glycine-N-acyltransferase	Homo sapiens	14-17
17585849-4	2007	Calculated ab initio values and semiempirical values for oxygen-17 and deuterium quadrupole coupling constants (chi) of water/CCl4 clusters are reported.	Water	120-125	C-C motif chemokine ligand 4	Homo sapiens	126-130
17585849-5	2007	Experimental values for the 17O, 2H, and 1H NMR spin-lattice relaxation times, T1, of 0.03 mole percent water in dilute CCl4 solution at 291 K are 94+/-3 ms, 7.0+/-0.2 s, and 12.6+/-0.4 s, respectively.	Water	104-109	C-C motif chemokine ligand 4	Homo sapiens	120-124
33916181-2	2021	The contrast agents showed MR relaxivities typical of gadolinium complexes with a single water molecule coordinated to a Gd3+ center (i.e., ~4.54 mM-1s-1) for both CA1 and CA2 at 60 MHz.	Water	89-94	carbonic anhydrase 1	Homo sapiens	164-167
33916181-2	2021	The contrast agents showed MR relaxivities typical of gadolinium complexes with a single water molecule coordinated to a Gd3+ center (i.e., ~4.54 mM-1s-1) for both CA1 and CA2 at 60 MHz.	Water	89-94	carbonic anhydrase 2	Homo sapiens	172-175
33885638-0	2021	A fluorescent aptasensor based on berberine for ultrasensitive detection of bisphenol A in tap water.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
33885638-5	2021	The proposed fluorescent sensing system also exhibited excellent recoveries of 92.4-102.3% in tap water samples and showed good application prospects for the analysis and detection of BPA.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
17585849-10	2007	These values indicate that the motion of monomer water in CCl4 is anisotropic.	Water	49-54	C-C motif chemokine ligand 4	Homo sapiens	58-62
17585849-17	2007	These values are a factor of about 20 longer than the tauc value for dilute monomer water in CCl4.	Water	84-89	C-C motif chemokine ligand 4	Homo sapiens	93-97
17711230-3	2007	The reversible "on/ off" switching of Fe3+/Fe2+ complexation with SSA, coupled with the phenol/phenoxyl radical conversion of the o-phenoxyl moiety of SSA, produces an ideal catalytic system that separates the Fenton reaction and the followed oxidations by *OH radicals (in water phase) from the regeneration of the catalytic species, Fe (SSA)2-, which occurs on the surface of resin.	Water	274-279	Ro60, Y RNA binding protein	Homo sapiens	339-344
33975055-5	2021	As the river traverses Delhi NCR, water quality deteriorates considerably as indicated by the Water Quality Index at the selected sampling sites.	Water	94-99	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	29-32
33883730-5	2021	Poly(caprolactone) and poly(lactic acid) containing less than 2 weight per cent enzymes are depolymerized in days, with up to 98 per cent polymer-to-small-molecule conversion in standard soil composts and household tap water, completely eliminating current needs to separate and landfill their products in compost facilities.	Water	219-224	nuclear RNA export factor 1	Homo sapiens	215-218
33543563-0	2021	Docetaxel chemotherapy response in PC3 prostate cancer mouse model detected by rotating frame relaxations and water diffusion.	Water	110-115	proprotein convertase subtilisin/kexin type 1	Mus musculus	35-38
33924156-3	2021	The CAT enzyme translates the hydrogen peroxide (H2O2) to water (H2O) and reduce the ROS levels to shelter the cells" death.	Water	58-63	catalase-3-like	Brassica napus	4-7
17575980-4	2007	Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively.	Water	121-126	solute carrier family 23 member 1	Homo sapiens	73-80
33924156-3	2021	The CAT enzyme translates the hydrogen peroxide (H2O2) to water (H2O) and reduce the ROS levels to shelter the cells" death.	Water	49-52	catalase-3-like	Brassica napus	4-7
33734012-11	2021	Thus, MED1 may serve as an integrator of multiple transcriptional pathways involved in these metabolic processes.Abbreviations: BAF: bafilomycin A1; db/db mice; Leprdb/db mice; ECAR: extracellular acidification rate; KD: knockdown; MED1: mediator complex subunit 1; NAFLD: nonalcoholic fatty liver disease; OCR: oxygen consumption rate; PPARA/PPARalpha: peroxisomal proliferator activated receptor alpha; TF: transcription factor; TFEB: transcription factor EB; tf-LC3: tandem fluorescence RFP-GFP-LC3; TG: triglyceride; TH: Thyroid hormone; TR: thyroid hormone receptors; V-ATPase: vacuolar-type H+-ATPase; WDF: Western diet with 15% fructose in drinking water.	Water	656-661	mediator complex subunit 1	Mus musculus	6-10
17611538-1	2007	Images of geomorphological features that seem to have been produced by the action of liquid water have been considered evidence for wet surface conditions on early Mars.	Water	92-97	methionyl-tRNA synthetase 1	Homo sapiens	164-168
33796071-5	2021	Our immunohistochemical work shows that hypothalamic AVP cellular activity, as recognized by c-fos, was enhanced in parallel with an elevation in TonEBP expression within AVP cells following water deprivation.	Water	191-196	nuclear factor of activated T cells 5	Mus musculus	146-152
33551058-10	2021	In addition, successful detection of Cr6+ in tap water and Yangtze River water, indicating the real applications of Au NDC@Ag NRs probe in monitoring Cr6+ in environment.	Water	73-78	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	150-153
33667846-3	2021	Among which compound 11m showed most potent P2Y14 antagonizing activity with an IC50 value of 2.18 nM, furnishing greatly improved water solubility and bioavailability compared with PPTN.	Water	131-136	purinergic receptor P2Y, G-protein coupled, 14	Mus musculus	44-49
33834580-0	2021	Engineering High-Spin State Cobalt Cations in Spinel Zinc Cobalt Oxide for Spin Channel Propagation and Active Site Enhancement in Water Oxidation.	Water	131-136	spindlin 1	Homo sapiens	17-21
33834580-0	2021	Engineering High-Spin State Cobalt Cations in Spinel Zinc Cobalt Oxide for Spin Channel Propagation and Active Site Enhancement in Water Oxidation.	Water	131-136	spindlin 1	Homo sapiens	46-50
33836748-1	2021	Ethanol: water mixture against HIV associated chronic CD4+ T-cell activation/ exhaustion.	Water	9-14	CD4 molecule	Sus scrofa	54-57
17376764-8	2007	The increased basolateral expression of AQP2 induced by aldosterone may play a significant role in water metabolism in conditions with increased sodium reabsorption in the CCD.	Water	99-104	aquaporin 2	Rattus norvegicus	40-44
33681944-7	2021	RESULTS: LPS and NLRP1 overexpression significantly increased the NLRP1 levels, reduced neurological function, and aggravated neuronal damage, as demonstrated by the impact latency time of, time spent by, and length of the platform covered by, the mice in the Morris water maze assay, Nissl staining, and immunofluorescence staining in rats with AD.	Water	267-272	NLR family, pyrin domain containing 1A	Mus musculus	17-22
17463181-4	2007	Therefore, we sought to determine whether leptin would alter the expression of genes involved in water and ion transport across the gallbladder epithelium.	Water	97-102	leptin	Mus musculus	42-48
33738073-3	2021	Crystallographic studies with HPK1 revealed a favorable water-mediated interaction with Asp155 and a salt bridge to Asp101 with optimized heterocyclic solvent fronts that were critical for enhanced potency and selectivity.	Water	56-61	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	30-34
33917350-4	2021	Calculated pKa values from a variety of theoretical methods indicated that the SMDBONDI method of accounting for solvent and van der Waals radii plus including a water molecule located near the site of protonation produced the closest overall agreement with the experimental values at 7.33 and 6.14 for AH+ and BH+ respectively.	Water	162-167	bleomycin hydrolase	Homo sapiens	311-313
33153793-6	2021	NP1 stabilized the size of otherwise unstable nMOx suspension in the tap-water for a longer period, whereas, aggregation was observed with NP2.	Water	73-78	neuropilin 1a	Danio rerio	0-3
33522413-2	2021	Engagement of ligand with the AVPR2 results in aquaporin 2 movement to the apical membrane and water reabsorption from the urinary filtrate.	Water	95-100	arginine vasopressin receptor 2	Mus musculus	30-35
17463181-7	2007	Leptin repletion upregulated the expression of aquaporin 1 water channel by 1.3-fold and downregulated aquaporin 4 by 2.3-fold.	Water	59-64	leptin	Mus musculus	0-6
33522413-4	2021	Here we identify novel roles for PAX2, a transcription factor crucial for kidney development, and its adaptor protein PTIP for epigenetic regulation of the Avpr2 and thus body water balance.	Water	176-181	arginine vasopressin receptor 2	Mus musculus	156-161
17463181-12	2007	Thus leptin, an adipocyte-derived cytokine involved with satiety and energy balance, influences gallbladder bile volume, sodium, and pH as well as multiple inflammatory cytokine genes and genes related to water, sodium, chloride, and bicarbonate transport.	Water	205-210	leptin	Mus musculus	5-11
17625320-4	2007	When the indole moiety in PLT was changed to benzene, in forming a new fluoroionophore of N-[4-(1-pyrene)butyroyl]-L-phenylalanine (PLP), it could not form a pyrene dimer in response to Pb(2+) in water.	Water	196-201	N-acylethanolamine acid amidase	Homo sapiens	26-29
33205489-2	2021	We showed here that 3beta-hydroxysteroid-delta8, delta7-isomerase-deficient mice (TD), an analog for CHILD syndrome in humans, exhibited not only lower basal transepidermal water loss rates, but also accelerated permeability barrier recovery despite the lower expression levels of mRNA for epidermal differentiation marker-related proteins and lipid synthetic enzymes.	Water	173-178	phenylalkylamine Ca2+ antagonist (emopamil) binding protein	Mus musculus	20-65
33360184-0	2021	IRT1 and ZIP2 were involved in exogenous hydrogen-rich water-reduced cadmium accumulation in Brassica chinensis and Arabidopsis thaliana.	Water	55-60	iron-regulated transporter 1	Arabidopsis thaliana	0-4
33360184-0	2021	IRT1 and ZIP2 were involved in exogenous hydrogen-rich water-reduced cadmium accumulation in Brassica chinensis and Arabidopsis thaliana.	Water	55-60	ZRT/IRT-like protein 2	Arabidopsis thaliana	9-13
17446262-4	2007	In the present study with CYP2C9, cyt b5 exerted complex actions upon P450 oxidative reactions by affecting the rate of metabolite formation, the consumption of NADPH by cytochrome P450 reductase, and uncoupling of the reaction cycle to hydrogen peroxide and water.	Water	259-264	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	26-32
33470188-4	2021	In the kidney, PRR participates in water and salt balance, acid-base balance, autophagy and plays a role in development and progression of hypertension, diabetic retinopathy, and kidney fibrosis.	Water	35-40	ATPase H+ transporting accessory protein 2	Homo sapiens	15-18
33180282-3	2021	The present study aimed to provide a survey of the existence of enteric viruses: human adenovirus (HAdV), human enteroviruses (hEV), and genotype A rotavirus (GARV) in tap water.	Water	172-177	nuclear RNA export factor 1	Homo sapiens	168-171
33453256-4	2021	Furthermore, the SA/CNF/PVA-based hydrogels showed a higher water-retention capacity in both deionized water and mixed soil.	Water	60-65	NPHS1 adhesion molecule, nephrin	Homo sapiens	20-23
33453256-4	2021	Furthermore, the SA/CNF/PVA-based hydrogels showed a higher water-retention capacity in both deionized water and mixed soil.	Water	103-108	NPHS1 adhesion molecule, nephrin	Homo sapiens	20-23
33493870-9	2021	We found that the Notch signaling pathway was activated and the Th17 frequency was elevated in rats with EAU, leading to disrupted CD4+/CD8+ and Th17/Treg balance.	Water	105-108	Cd4 molecule	Rattus norvegicus	131-134
17446262-4	2007	In the present study with CYP2C9, cyt b5 exerted complex actions upon P450 oxidative reactions by affecting the rate of metabolite formation, the consumption of NADPH by cytochrome P450 reductase, and uncoupling of the reaction cycle to hydrogen peroxide and water.	Water	259-264	cytochrome b5 type A	Homo sapiens	34-40
17560387-5	2007	The LODs and LOQs thus obtained were 1 and 3.2 microg for Pb and 1.8 and 4.8 microg for Cd, respectively; values which allow using the approach for the analysis of waste water by injecting 20 mL of sample into the FI manifold.	Water	170-175	TARBP2 subunit of RISC loading complex	Homo sapiens	13-17
32651745-0	2021	Treatment of Cyclic Vomiting Syndrome: Is Bathing a Panacea or Is It in Hot Water?	Water	76-81	alcohol dehydrogenase iron containing 1	Homo sapiens	72-75
33373730-9	2021	CONCLUSION: pKAM260_2, the self-transmissible plasmid carrying the blaKPC-2 gene, was detected from a hospital sewage water in Japan and characterized as pKpQIL-like plasmid.	Water	118-123	KPC-2	Escherichia coli	67-75
33369250-6	2021	The results reported in this paper show that CoP/NF, a layered bifunctional electrocatalyst, is a cost-effective and efficient water splitting electrode.	Water	127-132	neurofascin	Homo sapiens	49-51
17523628-7	2007	-3 kcal/mol is predicted for the eta(2)- to eta(1)- transition in water.	Water	66-71	secreted phosphoprotein 1	Homo sapiens	44-50
33614462-6	2021	The easiest and readily available rinsing solution is tap water, which fulfils the crucial criteria conveniently in most industrialized countries: purity, sterility, and neutral pH.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
17497776-2	2007	chi3 measurements of amido acid functionalized fused quartz/water interfaces are consistent with two acid-base equilibria, suggesting the formation of a laterally hydrogen-bonded environment similar to what is observed for aliphatic carboxylic acids.	Water	60-65	chitinase 1	Homo sapiens	0-4
33600095-3	2021	We aimed to investigate the cord level of Copeptin, Total serum oxidant (TOS), antioxidant (TAS), interleukin (IL) -1, IL-6, and oxytocin after the labor with water immersion, epidural analgesia, and vaginal birth without pain relief.	Water	159-164	oxytocin/neurophysin I prepropeptide	Homo sapiens	129-137
33571202-6	2021	We identified lack of access to tap water (<=98%) as an important risk factor for dengue virus IgG sero-positivity (adjusted Odds Ratio 4.69, 95% C.I.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
33493505-2	2021	Here we investigated the effect of chemerin on the food and water consumption and on the body weight in chicken.	Water	60-65	retinoic acid receptor responder (tazarotene induced) 2	Gallus gallus	35-43
32631738-10	2021	RESULTS: Tap water did not change spine phantom measurements, but did increase (p < 0.05) total body phantom lean mass 46 g and 89 g with 45 mL and 90 mL, respectively.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
33571202-12	2021	Control strategies based on improved access to a reliable supply of tap water plus focal intervention in intra-urban heat islands prior to the dengue season could not only lead to a reduction in mosquito abundance but also eliminate the reservoir of dengue virus clearly circulating at low levels in winter in socio-economically disadvantaged areas.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
17626470-2	2007	It is meant to purposely highlight the reality of the situation in Central Asia: the Aral Sea that was once a thriving body of water is no more.	Water	127-132	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	90-93
33547895-4	2021	RESULTS: High incidence rates were significantly associated with precarious water service index (0-25% coverage) and offstandard faecal coliforms index for tap water (5-50% and 75-100% of samples tested).	Water	160-165	nuclear RNA export factor 1	Homo sapiens	156-159
33547337-4	2021	The photocatalytic decomposition of benzene in water by the present hybrid heated at 1100  C was efficient as that by P25, a benchmark photocatalyst.	Water	47-52	tubulin polymerization promoting protein	Homo sapiens	118-121
33538957-1	2021	Apart from VEGF-A pathway activation, the existence of peritumoral edema (PTBE) in meningiomas has been correlated with the expression levels of water transporter aquaporin 4 (AQP4).	Water	145-150	aquaporin 4	Homo sapiens	163-174
33538957-1	2021	Apart from VEGF-A pathway activation, the existence of peritumoral edema (PTBE) in meningiomas has been correlated with the expression levels of water transporter aquaporin 4 (AQP4).	Water	145-150	aquaporin 4	Homo sapiens	176-180
31999938-9	2021	MiR-126 overexpression also inhibited reactive oxygen species and malondialdehyde levels and enhanced superoxide dismutase levels, as well as increased angiopoietin (Ang)1 expression and decreased Ang2 expression in H2O2-treated EPCs.	Water	216-220	angiogenin, ribonuclease A family, member 2	Rattus norvegicus	197-201
33599736-2	2021	Aquaporin-4 (AQP4), a water channel, plays an important role in water dynamics in the central nervous system and is also present in the ocular tissue.	Water	22-27	aquaporin 4	Mus musculus	0-11
33599736-2	2021	Aquaporin-4 (AQP4), a water channel, plays an important role in water dynamics in the central nervous system and is also present in the ocular tissue.	Water	22-27	aquaporin 4	Mus musculus	13-17
33599736-2	2021	Aquaporin-4 (AQP4), a water channel, plays an important role in water dynamics in the central nervous system and is also present in the ocular tissue.	Water	64-69	aquaporin 4	Mus musculus	0-11
33599736-2	2021	Aquaporin-4 (AQP4), a water channel, plays an important role in water dynamics in the central nervous system and is also present in the ocular tissue.	Water	64-69	aquaporin 4	Mus musculus	13-17
33599736-3	2021	The purpose of this study was to reveal the role of AQP4 in the water dynamics of the posterior eye using in vivo JJ vicinal coupling proton exchange (JJVCPE) magnetic resonance imaging (MRI) of AQP4 knockout (KO) mice and their wild-type littermates (controls).	Water	64-69	aquaporin 4	Mus musculus	52-56
33599736-8	2021	Conclusions: The present study using JJVCPE MRI of the eye demonstrated that retinal AQP4 has a potential role in the regulation of water inflow into the vitreous body.	Water	132-137	aquaporin 4	Mus musculus	85-89
33599736-9	2021	Absence of AQP4 in the KO mice probably induces lower water outflow from the vitreous body.	Water	54-59	aquaporin 4	Mus musculus	11-15
33359781-0	2021	Water treadmill training protects the integrity of the blood-spinal cord barrier following SCI via the BDNF/TrkB-CREB signalling pathway.	Water	0-5	brain-derived neurotrophic factor	Rattus norvegicus	103-107
33499674-3	2022	About 72% of the population used tap water for drinking and cooking.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
33499674-6	2022	These data indicated that fluoride concentration in tap water is higher than bottled water and estimated micronutrients intake is related to urinary fluoride.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
33500024-9	2021	Moreover, the PEI-CQDs are also successfully utilized for monitoring the Co2+ content of tap water.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
33586133-3	2021	The CBF response to incremental heat strain was dependent on the mode of heating, decreasing by 30% when exposed passively to hot, humid air (sauna), while remaining unchanged or increasing with passive hot-water immersion (spa) and exercising in a hot environment.	Water	207-212	surfactant protein A2	Homo sapiens	224-227
33863451-0	2021	Short-term hot water immersion results in substantial thermal strain and partial heat acclimation; comparisons with heat-exercise exposures.	Water	15-20	alcohol dehydrogenase iron containing 1	Homo sapiens	11-14
33863451-1	2021	OBJECTIVE: To examine the effectiveness of hot water immersion (HWI) as a heat acclimation strategy in comparison to time and temperature matched, exercise-heat acclimation (EHA).	Water	47-52	alcohol dehydrogenase iron containing 1	Homo sapiens	43-46
32658340-10	2021	Dehydration induced by restricted water access downregulated the gene expression of interleukin-1alpha and desmoglein-1 (P <= .05).	Water	34-39	desmoglein 1	Rattus norvegicus	107-119
32283105-0	2021	Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice.	Water	71-76	copine VII	Mus musculus	0-8
33735498-3	2021	Having discovered recently a differentially high expression of a BSCs proton pump, AHA2, we now test the hypothesis that it regulates the xylem-sap pH and leaf radial water fluxes.	Water	167-172	H[+]-ATPase 2	Arabidopsis thaliana	83-87
33735498-9	2021	All these demonstrate a causative link between AHA2 activity in BSCs and leaf radial hydraulic water conductance.	Water	95-100	H[+]-ATPase 2	Arabidopsis thaliana	47-51
33513424-5	2021	PVA content affects the swelling and water retention of CD/PVA hydrogels.	Water	37-42	cathepsin D	Mus musculus	56-62
33907644-7	2021	We will explore the role of the sodium/potassium adenosine triphosphatase (ATPase) pump on choroid plexus epithelial cells and the aquaporin-4 water receptors located on astrocyte end-feet and their complex interactions with the tetracyclines, mineralocorticoids, and therapeutic agents with carbonic anhydrase activity.	Water	143-148	aquaporin 4	Homo sapiens	131-142
33790744-3	2021	AQP4, the water channel that is found in high abundance in astrocyte end-feet, was expressed at moderately high levels in early passages, and its mRNA and protein declined to low but still detectable levels by p10.	Water	10-15	aquaporin 4	Mus musculus	0-4
33100379-4	2021	In the present work, the first time the molecular structure of ATZ molecule has been studied using Density Functional Theory (CAMB3LYP/6-31G*) in solvent water.	Water	154-159	camb3lyp/6	None	126-136
33524635-0	2021	Identification of MIB producers and odor risk assessment using routine data: A case study of an estuary drinking water reservoir.	Water	113-118	MIB E3 ubiquitin protein ligase 1	Homo sapiens	18-21
33524635-1	2021	Identification of MIB(2-methylisoborneol)-producing cyanobacteria in source water has been a big challenge for reservoir authorities because it normally requires isolation of cyanobacteria strains.	Water	76-81	MIB E3 ubiquitin protein ligase 1	Homo sapiens	18-21
33524635-2	2021	Here, a protocol based on Pearson"s product moment correlation analysis combined with standardized data treatment and expert judgement was developed to sort out the MIB producer(s), mainly based on routine monitoring data from an estuary drinking water reservoir in the Yangtze River, China, and a risk model using quantile regressions was established to evaluate the risk of MIB occurrences.	Water	247-252	MIB E3 ubiquitin protein ligase 1	Homo sapiens	165-168
33524635-7	2021	The risk model shows that the probability of suffering unacceptable MIB concentrations (>15 ng L-1) in water is as high as 90% if the cell density of Planktothrix is >609.0 cell mL-1, while the risk will be significantly reduced to 50% and 10% at cell densities of 37.5 cell mL-1 and 9.6 cell mL-1, respectively.	Water	103-108	MIB E3 ubiquitin protein ligase 1	Homo sapiens	68-71
33524635-8	2021	The approach developed in this study, including the protocol for identification of potential producers and the risk model, could provide a reference case for the management of source water suffering from MIB problems using routine monitoring data.	Water	183-188	MIB E3 ubiquitin protein ligase 1	Homo sapiens	204-207
33745421-1	2021	Sustainable crop improvement can help to feed the exploding human population in an era of shrinking cultivable lands and dwindling water resources.	Water	131-136	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	12-16
33684132-8	2021	We show that Crz acts to restore water/ion homeostasis by inhibiting release of CAPA neuropeptides via inhibition of cAMP production in Va neurons.	Water	33-38	Corazonin	Drosophila melanogaster	13-16
33160072-11	2021	We also measured intake of sucrose, quinine, and water after CNO treatment and found that increasing NAc core activity via CNO/hM3Dq increased quinine intake, and increased water intake over time.	Water	49-54	biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino	Mus musculus	123-126
33160072-11	2021	We also measured intake of sucrose, quinine, and water after CNO treatment and found that increasing NAc core activity via CNO/hM3Dq increased quinine intake, and increased water intake over time.	Water	173-178	biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino	Mus musculus	123-126
33206556-2	2021	The aims of the present study were to determine if Gpr160 is required for the CARTp"s ability to reduce food and water intake and to initially identify the distribution of Gpr160-like immunoreactivity (Gpr160ir) in the rat brain.	Water	113-118	CART prepropeptide	Rattus norvegicus	78-83
33206556-4	2021	Passive immunoneutralization of Gpr160 in the 4V blocked the actions of CARTp to inhibit food and water intakes.	Water	98-103	CART prepropeptide	Rattus norvegicus	72-77
33333175-8	2021	In rat models, up-regulation of miR-26a could attenuate brain water content, Evans blue content, apoptosis, pathological injury and expression of CTGF and Bax, while promoted number of Nissl bodies and expression of miR-26a and Bcl-2 in the nervous cells in brain in ICH rats.	Water	62-67	microRNA 26a	Rattus norvegicus	32-39
33426799-4	2021	AQP4-IgG targets the astrocytic AQP4 water channel leading to complement activation and increased blood-brain barrier permeability.	Water	37-42	aquaporin 4	Homo sapiens	0-4
33426799-4	2021	AQP4-IgG targets the astrocytic AQP4 water channel leading to complement activation and increased blood-brain barrier permeability.	Water	37-42	aquaporin 4	Homo sapiens	32-36
33729218-5	2021	About 80% of patients have antibodies directed against the aquaporin-4 (AQP4) protein that form membrane-bound water transporters in the central nervous system (CNS).	Water	111-116	aquaporin 4	Homo sapiens	59-70
33729218-5	2021	About 80% of patients have antibodies directed against the aquaporin-4 (AQP4) protein that form membrane-bound water transporters in the central nervous system (CNS).	Water	111-116	aquaporin 4	Homo sapiens	72-76
33474763-1	2021	Aquaporin-4 is a transmembrane water channel protein, the C-terminal domain of which is facing the cytosol.	Water	31-36	aquaporin 4	Homo sapiens	0-11
33127052-0	2021	Enriched oxygen vacancies of Cu2O/SnS2/SnO2 heterostructure for enhanced photocatalytic reduction of CO2 by water and nitrogen fixation.	Water	108-113	strawberry notch homolog 2	Homo sapiens	39-42
33841003-11	2021	Conclusion: GK-OCMC Nps are potential nanocarriers for delivering hydrophobic drugs, thereby enhancing water solubility and permeability and improving the antiproliferative effects of GK.	Water	103-108	glycerol kinase	Homo sapiens	12-14
17339884-6	2007	The expression of caspase-3 and caspase-9 induced by H(2)O(2) in HLE cells was significantly reduced by parthenolide both at the protein and mRNA levels, and the activation of caspase-3 and caspase-9 was also suppressed by parthenolide in a dose-dependent manner.	Water	53-58	caspase 9	Homo sapiens	32-41
17339884-6	2007	The expression of caspase-3 and caspase-9 induced by H(2)O(2) in HLE cells was significantly reduced by parthenolide both at the protein and mRNA levels, and the activation of caspase-3 and caspase-9 was also suppressed by parthenolide in a dose-dependent manner.	Water	53-58	caspase 9	Homo sapiens	190-199
33518332-1	2021	Primary breeder guidelines indicate that 95% of the chicks assessed should present a crop that is full, soft, and rounded after 24 h, which indicates chicks have successfully located feed and water.	Water	192-197	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	85-89
17448517-5	2007	Ratios in river water concentrations of BAP attributed to the SPM (0.1-1.0 microgPl(-1)) to PO(4)-P had the greatest range at baseflow (0.01-0.80) with larger values for low land use intensity catchments.	Water	16-21	prohibitin 2	Homo sapiens	40-43
33404737-11	2021	On the fourth treatment day, oxytocin decreased ethanol intake and water intake.	Water	67-72	oxytocin	Mus musculus	29-37
17461560-5	2007	This serious discrepancy between the MP2 and the B3LYP results suggests an importance of dispersion interactions for discussions on thermodynamics of water octamers.	Water	150-155	tryptase pseudogene 1	Homo sapiens	37-40
33310583-0	2021	Corrigendum to "Using water quality and isotope studies to inform research in chronic kidney disease of unknown aetiology endemic areas in Sri Lanka" [Sci.	Water	22-27	sorcin	Homo sapiens	139-142
33141452-4	2021	In the presence of phenylcarbinol, ACN exhibited excellent pure water-splitting ability (95.3 mumol/h) and in the meanwhile phenylcarbinol was selectively oxidized to benzaldehyde (conversion of 90.9%, selectivity of 99.7%) under solar irradiation.	Water	64-69	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	35-38
33469483-9	2021	Western blotting showed decreased expression of the NOX4 protein and decreased expression of ROS in retinal tissue; the Morris water maze test results showed that NOX4 interference significantly decreased the escape latency of the rats.	Water	127-132	NADPH oxidase 4	Rattus norvegicus	163-167
33396064-3	2021	In this work, we investigate the reductive transformation of Cr6+ by ferrous ions (Fe2+) in ice at -20  C, and compare the same process in water at 25  C. The Fe2+-mediated reduction of Cr6+ occurred much faster in ice than it did in water.	Water	139-144	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	186-189
33396064-3	2021	In this work, we investigate the reductive transformation of Cr6+ by ferrous ions (Fe2+) in ice at -20  C, and compare the same process in water at 25  C. The Fe2+-mediated reduction of Cr6+ occurred much faster in ice than it did in water.	Water	234-239	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	61-64
33396064-3	2021	In this work, we investigate the reductive transformation of Cr6+ by ferrous ions (Fe2+) in ice at -20  C, and compare the same process in water at 25  C. The Fe2+-mediated reduction of Cr6+ occurred much faster in ice than it did in water.	Water	234-239	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	186-189
17291700-9	2007	The plant marc was extracted with distilled water (AB-4).	Water	44-49	immunoglobulin kappa variable 4-62	Mus musculus	51-55
33449947-10	2021	Furthermore, we observed that compared to the ethyl acetate (EtOAc) extract, the water extract of Y30 extract considerably promoted the survival of cells infected with A/PR/8/34 virus.	Water	81-86	a/pr/8/34	None	168-177
17337204-1	2007	The water channel, Aquaporin-9 (AQP9) is enriched in selected neuronal populations and is unique its ability to act as a lactate-glycerol channel supplying neurons with alternative fuel under ischaemic conditions.	Water	4-9	aquaporin 9	Mus musculus	19-30
33000516-3	2021	Here, we report how selective H3O+ intercalation in a neutral ZnCl2 electrolyte can be achieved for water-proton co-intercalated alpha-MoO3 (denoted WP-MoO3 ).	Water	100-105	H3 clustered histone 15	Homo sapiens	30-33
33000516-4	2021	H2O molecules located between MoO3 interlayers are disclosed to block Zn2+ intercalation pathways while allowing smooth H3O+ intercalation/diffusion through a Grotthuss proton conduction mechanism.	Water	0-3	H3 clustered histone 15	Homo sapiens	120-123
33679755-2	2021	Its defining autoantibody is specific for the water channel protein, aquaporin-4 (AQP4), which primarily is localized at the end-feet of astrocytes.	Water	46-51	aquaporin 4	Homo sapiens	69-80
33679755-2	2021	Its defining autoantibody is specific for the water channel protein, aquaporin-4 (AQP4), which primarily is localized at the end-feet of astrocytes.	Water	46-51	aquaporin 4	Homo sapiens	82-86
17337204-1	2007	The water channel, Aquaporin-9 (AQP9) is enriched in selected neuronal populations and is unique its ability to act as a lactate-glycerol channel supplying neurons with alternative fuel under ischaemic conditions.	Water	4-9	aquaporin 9	Mus musculus	32-36
17388507-0	2007	A comparative study of carboxy myoglobin in saccharide-water systems by molecular dynamics simulation.	Water	55-60	myoglobin	Homo sapiens	31-40
33669577-8	2021	A severe reduction of vascular aquaporin-4-water channels, lower levels of high-functioning potassium channels, and higher metalloproteinases are also observed.	Water	43-48	aquaporin 4	Mus musculus	31-42
33669601-8	2021	These findings indicate that zebrafish Abcc4 plays a crucial role in lead detoxification and cellular efflux and could be used as a potential biomarker to monitor lead contamination in a water environment.	Water	187-192	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Danio rerio	39-44
32889473-7	2021	The partitioning behaviors of PFCAs in the water-sediment system varied depending on the CF2 moiety units.	Water	43-48	ATPase H+ transporting accessory protein 1	Homo sapiens	89-92
17326628-3	2007	In meso-2, the right/left-handed chirality of the originally formed chain is transferred oppositely to adjacent chains through the interchain hydrogen-bonding interactions of hexameric water clusters, leading to the formation of meso-2 with a central symmetrical space group, P21/n, in which the 1D helical chains are packed in an alternating right- and left-handed chirality.	Water	185-190	H3 histone pseudogene 16	Homo sapiens	276-279
33466393-1	2021	Amorphous solid dispersion drug delivery systems (ASD DDS) were proved to be efficient for the enhancement of solubility and bioavailability of poorly water-soluble drugs.	Water	151-156	arylsulfatase D	Homo sapiens	50-53
33545755-11	2021	Further analysis on the effect of different post-exercise recovery methods on the BLC and CK concentrations indicated that BLC (SMD =-1.16, 95% CI: -2.30, -0.02) was significantly lower in the group with cold water immersion compared with the control group, while there was no significant difference in the changes of CK concentration.	Water	209-214	cytidine/uridine monophosphate kinase 1	Homo sapiens	90-92
33730647-0	2021	Fe(III) loaded chitosan-biochar composite fibers for the removal of phosphate from water.	Water	83-88	general transcription factor IIE subunit 1	Homo sapiens	0-7
33730647-2	2021	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600  C for adsorptive removal of phosphate from water.	Water	222-227	general transcription factor IIE subunit 1	Homo sapiens	22-29
33545755-11	2021	Further analysis on the effect of different post-exercise recovery methods on the BLC and CK concentrations indicated that BLC (SMD =-1.16, 95% CI: -2.30, -0.02) was significantly lower in the group with cold water immersion compared with the control group, while there was no significant difference in the changes of CK concentration.	Water	209-214	cytidine/uridine monophosphate kinase 1	Homo sapiens	318-320
17259273-2	2007	We show that despite its simplicity, this computationally cheap model is capable of predicting acceptable water and protein behavior using the CHARMM22/CMAP potential function.	Water	106-111	cystatin F	Homo sapiens	152-156
32761705-0	2021	Multiexponential Analysis of the Water T2-Relaxation in the Skeletal Muscle Provides Distinct Markers of Disease Activity Between Inflammatory and Dystrophic Myopathies.	Water	33-38	solute carrier family 25 member 5	Homo sapiens	39-41
32761705-1	2021	BACKGROUND: The monoexponential water T2 (T2-mono ) is a proven biomarker of disease activity in neuromuscular disorders (NMDs).	Water	32-37	solute carrier family 25 member 5	Homo sapiens	38-40
32761705-1	2021	BACKGROUND: The monoexponential water T2 (T2-mono ) is a proven biomarker of disease activity in neuromuscular disorders (NMDs).	Water	32-37	solute carrier family 25 member 5	Homo sapiens	42-44
17382774-2	2007	MATERIALS AND METHODS: Spinal c-fos expression triggered by innocuous bladder distention (10 cm water) was studied in sham and lipopolysaccharide inflamed transient receptor potential vanilloid subfamily 1 +/+ and -/- mice.	Water	96-101	FBJ osteosarcoma oncogene	Mus musculus	30-35
32761705-3	2021	PURPOSE: To investigate the multiexponential behavior of the water T2 -relaxation in the skeletal muscle of NMD patients, aiming to identify more sensitive and specific biomarkers of disease activity.	Water	61-66	solute carrier family 25 member 5	Homo sapiens	67-69
17342341-7	2007	In MT1-transfected cells, aromatase activity (measured by the tritiated water release assay) was inhibited by melatonin (20% at 1 nM; 40% at 10 microM concentrations).	Water	72-77	metallothionein 1I, pseudogene	Homo sapiens	3-6
17388422-6	2007	Using molecular dynamics for Cu(I)-Atx1 in a box of water molecules and in vacuum, with the force field derived in this work, we observed a correlated motion between the side chains of Thr14 and of Lys65 which enhances distortions in the S-Cu-S geometry.	Water	52-57	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	35-39
17208229-4	2007	EAU was induced in Lewis rats using bovine S-antigen (S-Ag) peptide.	Water	0-3	S-antigen visual arrestin	Rattus norvegicus	43-52
17208229-4	2007	EAU was induced in Lewis rats using bovine S-antigen (S-Ag) peptide.	Water	0-3	S-antigen visual arrestin	Rattus norvegicus	54-58
17158169-0	2007	Water transport by GLUT2 expressed in Xenopus laevis oocytes.	Water	0-5	solute carrier family 2 member 2 S homeolog	Xenopus laevis	19-24
17158169-1	2007	The glucose transporter GLUT2 has been shown to also transport water.	Water	63-68	solute carrier family 2 member 2 S homeolog	Xenopus laevis	24-29
17158169-5	2007	Expression of GLUT2 induced a sugar permeability, P(S), of about 5 x 10(-6) cm s(-1) and a passive water permeability, L(p), of 5.5 x 10(-5) cm s(-1).	Water	99-104	solute carrier family 2 member 2 S homeolog	Xenopus laevis	14-19
17158169-6	2007	Accordingly, the passive water permeability of a GLUT2 protein is about 10 times higher than its sugar permeability.	Water	25-30	solute carrier family 2 member 2 S homeolog	Xenopus laevis	49-54
17158169-8	2007	Isosmotic addition of sugar to the bathing solution (replacing mannitol) induced two parallel components of water influx in GLUT2, one by osmosis and one by cotransport.	Water	108-113	solute carrier family 2 member 2 S homeolog	Xenopus laevis	124-129
17158169-10	2007	The diffusion coefficient was determined in oocytes coexpressing GLUT2 and the water channel AQP1 where water transport was predominantly osmotic.	Water	79-84	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	93-97
17158169-11	2007	By the cotransport mechanism about 35 water molecules were transported for each sugar molecule by a mechanism within the GLUT2.	Water	38-43	solute carrier family 2 member 2 S homeolog	Xenopus laevis	121-126
17360690-1	2007	Aquaporin-9 (AQP9) is an aquaglyceroporin membrane channel shown biophysically to conduct water, glycerol, and other small solutes.	Water	90-95	aquaporin 9	Mus musculus	0-11
17360690-1	2007	Aquaporin-9 (AQP9) is an aquaglyceroporin membrane channel shown biophysically to conduct water, glycerol, and other small solutes.	Water	90-95	aquaporin 9	Mus musculus	13-17
17286354-2	2007	A quantitative analysis of the bulk-water relaxation amplitude revealed the effective hydration number of a DSPE-PEG molecule per ethylene oxide monomer unit to be approximately 5.0-5.5, virtually independent of M(PEG).	Water	36-41	progestagen associated endometrial protein	Homo sapiens	113-116
17228919-2	2007	Homopolymeric polyalanine, Ac-(A)(21)-NHMe (A21), is unfolded in water by T-jumps from 273 to 300 K approximately 450 K using AMBER ff99 and ff03 force fields.	Water	65-70	immunoglobulin kappa variable 2-26 (pseudogene)	Homo sapiens	27-42
17228919-2	2007	Homopolymeric polyalanine, Ac-(A)(21)-NHMe (A21), is unfolded in water by T-jumps from 273 to 300 K approximately 450 K using AMBER ff99 and ff03 force fields.	Water	65-70	immunoglobulin kappa variable 2-26 (pseudogene)	Homo sapiens	44-47
17227015-5	2007	Energetic analysis at the MP2 level in the gas phase supported stronger Meimid binding over H2O binding to both UO2(Ac)2 and UO2(NO3)2.	Water	92-95	tryptase pseudogene 1	Homo sapiens	26-29
18356582-0	2007	Water extract of Cordyceps sinensis (WECS) inhibits the RANKL-induced osteoclast differentiation.	Water	0-5	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	56-61
17659514-5	2007	For the water-intercalated dimer it is calculated to be approximately 200 kJ mol(-1) according to the BSSE-corrected MP2 calculation.	Water	8-13	tryptase pseudogene 1	Homo sapiens	117-120
17676574-1	2007	Water-soluble carbon-nanohorn-tetrathiafulvalene (CNH-TTF) nanoensembles were prepared by utilizing positively charged pyrene as an assembly medium and characterized by spectroscopy and electron microscopy.	Water	0-5	ras homolog family member H	Homo sapiens	54-57
17492820-2	2007	High enantioselectivities (E usually &gt;100) were observed when the Candida antarctica lipase B catalyzed reactions were performed with H2O (0.5 equivalents) in iPr2O at 65 degrees C. The resolved products, obtained in good yields (&gt;or=42%), could be easily separated.	Water	137-140	PAN0_003d1715	Moesziomyces antarcticus	88-94
17433709-2	2007	Oral (gavage) administration of compound nutrients was found to attenuate the acute and chronic immobilization and cold water-immersion stress-induced increase in serum IL-6 level and decrease in IL-2 level.	Water	120-125	interleukin 2	Rattus norvegicus	196-200
17056099-1	2007	Aquaporin 3 (AQP3) acts as the membrane channel of water and other small solutes and plays a major role in fluid homeostasis.	Water	51-56	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
17056099-1	2007	Aquaporin 3 (AQP3) acts as the membrane channel of water and other small solutes and plays a major role in fluid homeostasis.	Water	51-56	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
17056099-11	2007	We conclude that AQP3 is widely expressed in the normal respiratory tract and can play an important role in the maintenance of water homeostasis.	Water	127-132	aquaporin 3 (Gill blood group)	Homo sapiens	17-21
17917069-6	2007	In addition, the identification of a water-soluble endotoxin:MD-2 complex that, depending on the structure of endotoxin or MD-2, has potent TLR4 agonist or antagonist properties suggests novel pharmacologic approaches to immuno-modulation.	Water	37-42	toll like receptor 4	Homo sapiens	140-144
33513036-2	2021	In AQP4-IgG seropositive NMOSD, circulating immunoglobulin G (IgG) autoantibodies against astrocyte water channel aquaporin-4 (AQP4) cause tissue injury.	Water	100-105	aquaporin 4	Homo sapiens	127-131
16770643-6	2007	Finally, molecular mechanics-Possion-Boltzmann/surface area calculations of the CDK5/indirubin-3"-oxime system in both water-excluded and water-included environments gave significantly different electrostatic contributions to the binding.	Water	119-124	cyclin dependent kinase 5	Homo sapiens	80-84
32909649-0	2021	Synchronous electrocatalytic design of architectural and electronic structure based on bifunctional LDH-Co3O4/NF towards water splitting.	Water	121-126	neurofascin	Homo sapiens	110-112
16770643-6	2007	Finally, molecular mechanics-Possion-Boltzmann/surface area calculations of the CDK5/indirubin-3"-oxime system in both water-excluded and water-included environments gave significantly different electrostatic contributions to the binding.	Water	138-143	cyclin dependent kinase 5	Homo sapiens	80-84
17064359-3	2007	Here, we have analysed by RNA interference technology the functional interactions occurring between the most abundant water channel in the brain, aquaporin-4 (AQP4), and the swelling-activated Cl(-) current expressed by cultured rat cortical astrocytes.	Water	118-123	aquaporin 4	Rattus norvegicus	146-157
33577345-6	2021	A phosphorylation-dependent switch between ion and water permeation in AtPIP2;1 might be explained by coupling between the gates of the four monomer water channels and the central pore of the tetramer.	Water	51-56	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	71-79
33577345-6	2021	A phosphorylation-dependent switch between ion and water permeation in AtPIP2;1 might be explained by coupling between the gates of the four monomer water channels and the central pore of the tetramer.	Water	149-154	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	71-79
33758757-1	2021	Background: The main objective of this study was to investigate the logics behind tendencies towards bottled drinking water usage in spite of availability of treated tap water.	Water	170-175	nuclear RNA export factor 1	Homo sapiens	166-169
32761705-7	2021	ASSESSMENT: Water T2 -decay curves generated from 1 H-MRS data acquired at 14 echo-times were fitted to mono- and biexponential models and the adjusted R2 of each fit was computed.	Water	12-17	solute carrier family 25 member 5	Homo sapiens	18-20
33994481-2	2021	Cystic fibrosis transmembrane conductance regulator (CFTR) is a well-characterized chloride channel that regulates several other ion channels and transporters to maintain water homeostasis in the gut lumen.	Water	171-176	cystic fibrosis transmembrane conductance regulator	Mus musculus	53-57
17064359-3	2007	Here, we have analysed by RNA interference technology the functional interactions occurring between the most abundant water channel in the brain, aquaporin-4 (AQP4), and the swelling-activated Cl(-) current expressed by cultured rat cortical astrocytes.	Water	118-123	aquaporin 4	Rattus norvegicus	159-163
17113653-4	2007	LF was given in drinking water as 0.25% solution beginning the day of elicitation of EAE or with a seven-day delay.	Water	25-30	lactotransferrin	Rattus norvegicus	0-2
33309338-2	2021	Serum antibodies of the IgG class to the water channel protein aquaporin-4 (AQP4) are associated with NMOSD in most cases.	Water	41-46	aquaporin 4	Homo sapiens	63-74
33309338-2	2021	Serum antibodies of the IgG class to the water channel protein aquaporin-4 (AQP4) are associated with NMOSD in most cases.	Water	41-46	aquaporin 4	Homo sapiens	76-80
33758757-9	2021	The perceived unreliability of tap water quality was the main reason of bottled water consumption among 74% of the respondents.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
33758757-9	2021	The perceived unreliability of tap water quality was the main reason of bottled water consumption among 74% of the respondents.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	31-34
17393065-4	2007	Nanodisc assemblies of MAO-A are water-soluble, yield increased enzyme stability relative to detergent solutions, are catalytically active, and reactive with acetylenic inhibitors.	Water	33-38	monoamine oxidase A	Homo sapiens	23-28
33464818-1	2021	We demonstrate that the photoactivity of bismuth oxyiodide (BiOI) nanoflake (NF) photocathodes in photo-electrochemical (PEC) water splitting can be significantly enhanced by about 24-fold by thermal calcination under an air atmosphere and then surficial decoration of Au nanoparticles (NPs).	Water	126-131	neurofascin	Homo sapiens	41-80
33530048-0	2021	A Young man with Peri-ictal water drinking.	Water	28-33	perilipin 1	Homo sapiens	17-21
33530048-2	2021	Among the rare known features is peri-ictal water drinking (PIWD).	Water	44-49	perilipin 1	Homo sapiens	33-37
18204296-3	2007	In the rat cold injury model, the VEGF receptor antagonist VGA1155 significantly reduced the brain water content and the maximum effect was obtained when given at 30 minutes after injury.	Water	99-104	vascular endothelial growth factor A	Rattus norvegicus	34-38
33374723-2	2020	Therefore, water-soluble polymers based on poly(aspartate-co-succinimide) were synthesized via reaction of poly(aspartate-co-succinimide) with bis-quaternary ammonium or quaternary salts.	Water	11-16	Bis protein	Escherichia coli	143-146
33285223-4	2021	By use of stereotactic injection and a Morris water maze, we found that delivery of Dicer1-expressing adenovirus into the hippocampus of an animal model of AD mice APPswe/PSEN1deltaE9 significantly improved spatial memory.	Water	46-51	dicer 1, ribonuclease type III	Mus musculus	84-90
17940347-1	2007	BACKGROUND/AIMS: The renal sodium glucose cotransporter (SGLT2) and the water channel aquaporin-2 (AQP2) play a critical role in tubular sodium and water reabsorption and in the regulation of extracellular fluid volume both in physiologic and pathophysiologic conditions.	Water	72-77	aquaporin 2	Rattus norvegicus	86-97
32854159-0	2021	Spectroscopic study of in situ formed metallocomplexes of proton pump inhibitors in water.	Water	84-89	ATPase H+/K+ transporting subunit alpha	Homo sapiens	58-69
33165199-7	2020	AQP4, the main water channel, was remarkably decreased in PCA group.	Water	15-20	aquaporin 4	Mus musculus	0-4
17940347-1	2007	BACKGROUND/AIMS: The renal sodium glucose cotransporter (SGLT2) and the water channel aquaporin-2 (AQP2) play a critical role in tubular sodium and water reabsorption and in the regulation of extracellular fluid volume both in physiologic and pathophysiologic conditions.	Water	72-77	aquaporin 2	Rattus norvegicus	99-103
18084894-3	2007	The NADH oxidase primarily catalyzes the reduction of oxygen by NADH to form H2O2, while the Prx immediately reduces H2O2 (or ROOH) to water (or ROH).	Water	135-140	periaxin	Homo sapiens	93-96
33327435-3	2020	The results showed that the water saturation of concrete with strength grades C15, C20, and C30 increased with an extension of immersion time, and the water saturation showed an approximately linear rapid growth within three soaking hours, reaching 47.56%, 71.63%, and 47.29%, respectively.	Water	28-33	placenta associated 8	Homo sapiens	78-81
33327435-4	2020	Note, the concrete reached saturation state when the soaking time was 240 h. The axial compressive strength with strength grades C15, C20, and C30 decreased with increased water saturation, and the axial compressive strength of saturated concrete decreased by 27.25%, 21.14%, and 20.76%, respectively, as compared with the dry state concrete.	Water	172-177	placenta associated 8	Homo sapiens	129-132
33327435-5	2020	The elastic modulus of concrete with strength grades C15, C20, and C30 increased with increased water saturation, and the elastic modulus of saturated concrete was 1.18, 1.19, and 1.24 times higher than those of dry concrete, respectively.	Water	96-101	placenta associated 8	Homo sapiens	53-56
33045559-0	2021	Tap water contamination: Multiclass endocrine disrupting compounds in different housing types in an urban settlement.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
33045559-1	2021	Contamination of endocrine disrupting compounds (EDCs) in tap water is an emerging global issue, and there are abundant influencing factors that have an ambivalent effect on their transportation and fate.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
33045559-3	2021	Thus, this study analyzed 18 multiclass EDCs in tap water from different housing types (i.e., landed and high-rise) and the associated health risks.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
33045559-4	2021	Sample analyses revealed the presence of 16 EDCs, namely hormones (5), pharmaceuticals (8), a pesticide (1), and plasticizers (2) in tap water, with the prevalent occurrence of bisphenol A up to 66.40 ng/L in high-rise housing.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
33045559-5	2021	The presence of caffeine and sulfamethoxazole distribution in tap water was significantly different between landed and high-rise housings (t(152) = -2.298, p = 0.023 and t(109) = 2.135, p = 0.035).	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
18084894-4	2007	Consequently, the NADH oxidase-Prx system catalyzes the reduction of both oxygen and hydrogen peroxide to water with NADH as the preferred electron donor.	Water	106-111	periaxin	Homo sapiens	31-34
33045559-6	2021	Moreover, the salinity and conductivity of tap water in high-rise housings were significantly higher compared to those in landed housings (t(122) = 2.411, p = 0.017 and t(94) = 2.997, p = 0.003, respectively).	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
33354944-4	2021	The experimental solubility of the [Cn THT][NTf2 ]-ILs in water (75 to 2.2 mg/L for C4 to C10 ) was modelled with very good agreement by Perturbed Chain Statistical Associating Fluid Theory (PC-SAFT), based on the extremely low vapor pressures for the [Cn THT][NTf2 ]-ILs measured in this work (4.15 to 0.037   10-7 xpsat for C4 to C10 ).	Water	58-63	nuclear transport factor 2	Homo sapiens	44-48
33278489-2	2021	Salvianolic acid A (SAA) is a water-soluble phenolic acid extracted from Salvia miltiorrhiza (Danshen) with anti-tumor properties.	Water	30-35	serum amyloid A cluster	Mus musculus	20-23
32951103-10	2021	Neurological dysfunction, brain water content, Evans Blue extravasation, microglial activation, and neuronal apoptosis were significantly reduced by GLP-1R agonist liraglutide.	Water	32-37	glucagon-like peptide 1 receptor	Rattus norvegicus	149-155
33289903-1	2021	The alternative oxidase (AOX) is a monotopic diiron carboxylate protein that catalyses the oxidation of ubiquinol and the reduction of oxygen to water.	Water	145-150	acyl-CoA oxidase 1	Homo sapiens	4-23
33289903-1	2021	The alternative oxidase (AOX) is a monotopic diiron carboxylate protein that catalyses the oxidation of ubiquinol and the reduction of oxygen to water.	Water	145-150	acyl-CoA oxidase 1	Homo sapiens	25-28
32987303-5	2021	The IGF1R c.654G > A genotypes were found to have a significant effect on the average daily gain between the 56th and 78th day of life, cold carcass, leg part, leg cut, fore shank, and kidney weights, as well as eye of loin depth, intramuscular fat content, and water-holding capacity of meat.	Water	262-267	insulin-like growth factor 1 receptor	Ovis aries	4-9
33103784-4	2021	The addition of hydrogen-rich water and expression of the hydrogenase1 gene (CrHYD1) from Chlamydomonas reinhardtii increased endogenous H2 and MT levels, and enhanced salinity tolerance.	Water	30-35	uncharacterized protein	Chlamydomonas reinhardtii	77-83
33278722-0	2021	Organic matter stabilized Fe in drinking water treatment residue with implications for environmental remediation.	Water	41-46	general transcription factor IIE subunit 1	Homo sapiens	26-28
33278722-4	2021	Typically, the addition of FeCl3 and Fe2(SO4)3 enhanced Fe mobility in sediment and overlying water, promoting the formation of Fe-humin acid and ferrous sulfides (FeS and FeS2).	Water	94-99	general transcription factor IIE subunit 1	Homo sapiens	27-29
33278722-4	2021	Typically, the addition of FeCl3 and Fe2(SO4)3 enhanced Fe mobility in sediment and overlying water, promoting the formation of Fe-humin acid and ferrous sulfides (FeS and FeS2).	Water	94-99	general transcription factor IIE subunit 1	Homo sapiens	37-39
32911162-10	2021	Tap water with MIB had the lowest acceptability mean score (3.43 +- 1.74), while flavorless bottled water had the highest acceptability mean score (6.23 +- 1.47).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
32889273-1	2021	As a new type of potentially threatening pollutant, microplastics are widely distributed in water and may come into contact with the humans through tap water.	Water	152-157	nuclear RNA export factor 1	Homo sapiens	148-151
33521096-6	2020	Early water deprivation directly affected the brain proopiomelanocortin (POMC) and hepatic glucocorticoid receptors (GR) expression and induced significant changes in various aquaporins (AQP1, AQP2, AQP4, and AQP9).	Water	6-11	aquaporin 4	Homo sapiens	199-203
33510758-6	2020	Guard cell-specific expression of AtHXK1 decreased stomatal conductance and improved water use efficiency of transgenic potato plants as has been shown for other crop plants.	Water	85-90	hexokinase 1	Arabidopsis thaliana	34-40
33585447-6	2020	Mitochondrial Ca2+ overload from the intracellular Ca2+-flux system located at the ER-mitochondrial axis can induce mitochondrial dilation during paraptosis, while the accumulation of misfolded proteins within the ER lumen is believed to exert an osmotic force and draw water from the cytoplasm to distend the ER lumen.	Water	270-275	carbonic anhydrase 2	Homo sapiens	14-17
33585447-6	2020	Mitochondrial Ca2+ overload from the intracellular Ca2+-flux system located at the ER-mitochondrial axis can induce mitochondrial dilation during paraptosis, while the accumulation of misfolded proteins within the ER lumen is believed to exert an osmotic force and draw water from the cytoplasm to distend the ER lumen.	Water	270-275	carbonic anhydrase 2	Homo sapiens	51-54
33430800-0	2021	Transgenic chickpea (Cicer arietinum L.) harbouring AtDREB1a are physiologically better adapted to water deficit.	Water	99-104	dehydration response element B1A	Arabidopsis thaliana	52-60
33430800-11	2021	CONCLUSIONS: Based on precise phenotyping, involving non-invasive chlorophyll fluorescence imaging, carbon isotope discrimination, osmotic adjustment, higher chlorophyll retention and membrane stability index, it can be concluded that AtDREB1a transgenic chickpea lines were better adapted to water deficit by modifying important physiological traits.	Water	293-298	dehydration response element B1A	Arabidopsis thaliana	235-243
33241573-4	2021	Photocatalytic water oxidation with this cyclic dinuclear Ru complex using [Ru(bpy)3 ]Cl2 as a standard photosensitizer revealed a turnover frequency of 15.5 s-1 and a turnover number of 460.	Water	15-20	endogenous retrovirus group W member 5	Homo sapiens	86-89
33389163-5	2021	In stage (ii), hydroxy group of water would help to break the bond between beta-NH2 group of L-lysine and PLP better than that of Tyr389.	Water	32-37	proteolipid protein 1	Homo sapiens	106-109
32896640-8	2021	The levels of IL-1b, IL-18, and TSLP exhibited positive correlations with the AD severity index (Scoring AD index) and skin transepidermal water loss (TEWL), whereas an inverse correlation between IL-1a and Scoring AD index and IL-1a and TEWL was found.	Water	139-144	interleukin 18	Homo sapiens	21-26
33569432-9	2021	Immunofluorescence and western blot analyses showed that glyphosate and hard water had a coordinated effect on calcium ions (Ca2+)-activated phospholipase A2 and the activation may play a key role in inflammation and renal tubular injury.	Water	77-82	phospholipase A2, group IB, pancreas	Mus musculus	141-157
33390526-0	2021	Characteristics of Raw and Acid-Activated Bentonite and Its Application for Improving Electrical Conductivity of Tap Water.	Water	117-122	nuclear RNA export factor 1	Homo sapiens	113-116
33390526-1	2021	This study aimed to investigate the characteristics of acid-activated bentonite by focusing on its capability of improving the quality of tap water used during wire electrical discharge machining.	Water	142-147	nuclear RNA export factor 1	Homo sapiens	138-141
33390526-6	2021	The electrical conductivity of tap water was decreased significantly due to bentonite activated with sulfuric acid, nitric acid, and phosphoric acid solution (removal percentage of approximately 31-39%), as compared to that due to RB.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
33390526-9	2021	These results indicated that acid-activated bentonite can be produced from RB via acid activation and that it can be used to decrease electrical conductivity of tap water.	Water	165-170	nuclear RNA export factor 1	Homo sapiens	161-164
33107589-6	2021	Our results indicate that albumin, alpha1 -m, beta2 -m, and RBP4 urinary excretion differ in their sensitivity to changes in the glomerular filtration rate, glomerular protein leak, tubular protein uptake via endocytosis, and PT water reabsorption.	Water	229-234	retinol binding protein 4	Homo sapiens	60-64
33310418-1	2021	BACKGROUND: Antibodies to the aquaporin-4 (AQP4) water channel in neuromyelitis optica spectrum disorder (NMOSD) are reported to trigger the complement cascade, which is implicated in astrocyte damage and subsequent neuronal injury.	Water	49-54	aquaporin 4	Homo sapiens	30-41
33310418-1	2021	BACKGROUND: Antibodies to the aquaporin-4 (AQP4) water channel in neuromyelitis optica spectrum disorder (NMOSD) are reported to trigger the complement cascade, which is implicated in astrocyte damage and subsequent neuronal injury.	Water	49-54	aquaporin 4	Homo sapiens	43-47
33196911-8	2021	Overexpression of miR-190 significantly reduced the increased neurological scores, brain water contents, infarct volumes, and neuronal apoptosis in rats suffering with I/R.	Water	89-94	microRNA 190	Rattus norvegicus	18-25
33279802-8	2021	Subgroup analysis demonstrated that COMP immediately or at 0.5 h after running was significantly increased, but there were no significant changes at 1 h or 2 h. CONCLUSIONS: Running has advantages in promoting nutrition penetrating into the cartilage as well as squeezing out the metabolic substance, such as water.	Water	309-314	cartilage oligomeric matrix protein	Homo sapiens	36-40
32841807-5	2021	Higher concentrations (median: 39.3 ng/L; range: 1.20-127) of selected pesticides were found in tap water from Hanoi than those from four other provinces studied (5.49 ng/L; 4.73-66.8 ng/L).	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
32841807-7	2021	The calculated risks from pesticide exposure through ingestion of tap water by the general populations were low.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
33396394-5	2020	About 70% of responding households possessed their own water sources, mostly shallow tube-wells, and owners were less likely to choose tap water for drinking purpose than nonowners.	Water	139-144	nuclear RNA export factor 1	Homo sapiens	135-138
32905588-5	2020	We found that the gravitropism-deficient mutant aux1 showed enhanced hydrotropism in the oblique orientation but impaired root elongation towards the water in a vertical orientation.	Water	150-155	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	48-52
32905588-9	2020	Additionally, gravity facilitated roots" search for vertically-oriented water, because the miz1/aux1 double-mutant showed attenuated root elongation towards the water in a vertical orientation, in contrast to miz1.	Water	72-77	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	96-100
32905588-9	2020	Additionally, gravity facilitated roots" search for vertically-oriented water, because the miz1/aux1 double-mutant showed attenuated root elongation towards the water in a vertical orientation, in contrast to miz1.	Water	161-166	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	96-100
33374246-7	2020	(3) Methods: in rats pretested for PPI, we evaluated the activity of synaptic membrane-bound and water-soluble choline acetyltransferase (ChAT) in the sub-fractions of "light" and "heavy" synaptosomes of the neocortex, hippocampus and caudal brainstem in the intact brain and after HBH.	Water	97-102	choline O-acetyltransferase	Rattus norvegicus	138-142
33374345-11	2020	Recoveries calculated for pharmaceutical products and tap water measurements were in the range 102-105%, which confirms the accuracy of the developed.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
33374345-12	2020	The applicability of the method was confirmed by analysis of pharmaceutical products and tap water samples.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
33332450-5	2020	After 18-hours of water deprivation, plasma aldosterone and urine osmolality increased significantly in Cx37-/- and WT mice; however, the latter remained ~375 mmol/kg lower in Cx37-/- mice, an effect associated with a more pronounced body weight loss despite higher urinary AVP/creatinine ratios compared to WT mice.	Water	18-23	gap junction protein, alpha 4	Mus musculus	104-108
33332450-9	2020	In summary, these results demonstrate that Cx37 is important for body water handling.	Water	70-75	gap junction protein, alpha 4	Mus musculus	43-47
32910479-3	2020	METHODS: The in-vitro reactions between the putative prodrug CNCbl-mCP with the NMPs of adenosine (AMP), guanosine (GMP), cytidine (CMP) and uridine (UMP) were carried out in slightly acid water/methanol solutions at 37  C for 24 h. Each sample was examined by reversed-phase liquid chromatography coupled with electrospray ionization in positive ion mode and tandem mass spectrometry (RPLC/ESI-MS/MS) by collision induced dissociation (CID) in a linear ion-trap mass spectrometer.	Water	189-194	CD46 antigen, complement regulatory protein	Mus musculus	67-70
33300501-3	2020	At PTB, a new water calorimeter has been designed which is capable to determine Dw,Q in an MR-linac.	Water	14-19	polypyrimidine tract binding protein 1	Homo sapiens	3-6
33322071-6	2020	In the case of the modified composition, it is noted that the samples immersed in tap water were characterized by a higher strength than in acidic environments.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
33317121-6	2020	The participants who consumed fluoridated (>=0.7 mg/L) tap water (n = 560, 16%) versus those who did not had 36% (95% CI: 22, 51) higher plasma fluoride.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
33317121-9	2020	The consumption of fluoridated tap water and tea substantially increases plasma fluoride concentrations in children.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
33001645-0	2020	Water Molecule-Induced Reversible Magnetic Switching in a Bis-Terpyridine Cobalt(II) Complex Exhibiting Coexistence of Spin Crossover and Orbital Transition Behaviors.	Water	0-5	spindlin 1	Homo sapiens	119-123
32593940-11	2020	This approach also shows excellent performance in monitoring Pb2+ in tap water and lake water.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
32607956-9	2020	The water fraction of root hydroalcoholic extract (PtR2), showed strong antiangiogenic effect with minimal adverse viability impacts.	Water	4-9	endogenous retrovirus group 9 member 1	Homo sapiens	51-55
33028492-6	2020	In the OP rats, the plasma concentrations in the groups given erlotinib in apple juice and in HCl (pH 3.7) were significantly higher than in the tap water group in the initial phase of absorption.	Water	149-154	nuclear RNA export factor 1	Homo sapiens	145-148
33161365-7	2020	An alternative, simple small molecules are widely applied as commercial biomarkers such as terephthalate and 2,3-diaminonaphthalene (NAP) for hydroxy radical (OH ) and nitric oxide (NO) respectively.	Water	142-157	catenin beta like 1	Homo sapiens	133-136
32621298-8	2020	Training in the water maze increased c-Fos positive nuclei in the dentate gyrus of the hippocampus and in medial prefrontal cortex.	Water	16-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-42
33176212-6	2020	In four meat chicken flocks vaccinated with A20 in water using two different water stabilization times (20 or 40 min), swabs from the trachea and choanal cleft and dust samples were collected at 0, 7, 14 and 21 dpv.	Water	51-56	immunoglobulin kappa variable 1-27	Homo sapiens	44-47
33339784-2	2020	A good alternative is an MBR system to treat the processing wastewater, followed by tertiary treatment using a reverse osmosis (RO) unit to enable water reuse.	Water	65-70	translocator protein	Homo sapiens	25-28
33238896-12	2020	Physicochemistry of more than 50% of the water samples revealed higher electric conductivity, salinity, total dissolved solids, total hardness and Na levels compared to drinking water standards in Sri Lanka.	Water	41-46	sorcin	Homo sapiens	197-200
33238896-15	2020	Thus, the total dissolved solids and arsenic in drinking water may have positive correlation with the occurrence of CKDu in Thunukkai region in the Mullaitivu District of Sri Lanka.	Water	57-62	sorcin	Homo sapiens	171-174
33303581-3	2021	Homer Smith"s teleologic argument that this high GFR was needed to excrete water as vertebrates evolved in dilute seas is outdated.	Water	75-80	Rap guanine nucleotide exchange factor 5	Homo sapiens	49-52
31903787-9	2020	In addition, HYP decreased the production of phosphorylated Jun N-terminal kinase (JNK) and p38 levels of osteoblastic MC3T3-E1 cells induced by H2O2.	Water	145-149	mitogen-activated protein kinase 8	Mus musculus	60-81
31903787-9	2020	In addition, HYP decreased the production of phosphorylated Jun N-terminal kinase (JNK) and p38 levels of osteoblastic MC3T3-E1 cells induced by H2O2.	Water	145-149	mitogen-activated protein kinase 8	Mus musculus	83-86
32631653-0	2020	Association of availability of tap water system with admission rate after 30 days among burn injury patients: A nationwide population-based study.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
32631653-1	2020	BACKGROUND: We investigated whether the availability of a tap water supply system is associated with lowering the admission rate 30 days after burn injury.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
32631653-10	2020	The advantageous effect of a well-equipped tap water system on a lower admission rate in burn patients was independent of comorbidities.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
32631653-11	2020	CONCLUSIONS: The results of this study demonstrated the association between lowering the admission rate at 30 days in burn patients in Taiwan and using a well-equipped tap water system.	Water	172-177	nuclear RNA export factor 1	Homo sapiens	168-171
32631653-12	2020	It also could offer important information to the government for enhancing the availability of tap water system in those areas lack adequate tap water supply which is useful to protect burn patients from following admission.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
32631653-12	2020	It also could offer important information to the government for enhancing the availability of tap water system in those areas lack adequate tap water supply which is useful to protect burn patients from following admission.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	140-143
32631653-12	2020	It also could offer important information to the government for enhancing the availability of tap water system in those areas lack adequate tap water supply which is useful to protect burn patients from following admission.	Water	144-149	nuclear RNA export factor 1	Homo sapiens	94-97
32631653-12	2020	It also could offer important information to the government for enhancing the availability of tap water system in those areas lack adequate tap water supply which is useful to protect burn patients from following admission.	Water	144-149	nuclear RNA export factor 1	Homo sapiens	140-143
33254200-5	2020	Tap water was administered through the sheath to create sufficient intraluminal pressure to manipulate devices and acquire digital subtraction angiography (DSA).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
33200608-9	2020	Notwithstanding, depleted micelles were less susceptible to enzymatic cross-linking by microbial transglutaminase (mTG), indicating narrowed water channels due to depletion.	Water	141-146	protease, serine 3	Mus musculus	115-118
33161988-2	2020	Carboxyl functionalized benzimidazolium based ILs were hierarchically synthesized and the water insoluble carboxylic IL was covalently attached with aminopropylmethyl viologen through DCC coupling to obtain water insoluble Vio-IL gel.	Water	90-95	DCC netrin 1 receptor	Homo sapiens	184-187
33161988-2	2020	Carboxyl functionalized benzimidazolium based ILs were hierarchically synthesized and the water insoluble carboxylic IL was covalently attached with aminopropylmethyl viologen through DCC coupling to obtain water insoluble Vio-IL gel.	Water	207-212	DCC netrin 1 receptor	Homo sapiens	184-187
33205943-5	2020	It is fascinating that AlP3-GaP3 ingeniously combines all the desired features for photocatalytic water-splitting reactions, including a nearly direct band gap (1.43 eV), perfect band edge position, high STH efficiency (16.89%), broad light absorption region of sunlight, ultrahigh carrier mobility (20,000 cm2 V-1 s-1), low exciton binding energy (0.33 eV), and excellent stability in a water environment.	Water	98-103	saitohin	Homo sapiens	204-207
33156308-1	2020	In this work PbMoO4 and Pb1-2xCaxSrxMoO4 (x = 0.1, 0.2, 0.3, 0.4 and 0.5) solid solutions have been successfully prepared, for the first time, by a simple co-precipitation method and the as-synthesized samples were subjected to a water-based reflux treatment.	Water	230-235	polybromo 1	Homo sapiens	24-27
32653715-3	2020	The primary aims of this study are to (i) quantify the variations in vegetable yields, N2O emissions, nitrogen use efficiency (NUE) and crop water productivity (CWP) under greenhouse cultivation conditions; (ii) determine the major regulating factors of vegetable yields, N2O emissions, emission factors (EFs), yield-scaled N2O emissions, NUEs and CWPs; and (iii) evaluate the effectiveness of fertilization and irrigation strategies for N2O mitigation.	Water	141-146	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	136-140
33209306-1	2020	Hot tub lung (HTL) is a pulmonary disease where a hypersensitivity pneumonitis is caused by exposure and inhalation of aerosolized non-tuberculous mycobacteria (NTM) traditionally from hot water steam.	Water	189-194	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
33209306-1	2020	Hot tub lung (HTL) is a pulmonary disease where a hypersensitivity pneumonitis is caused by exposure and inhalation of aerosolized non-tuberculous mycobacteria (NTM) traditionally from hot water steam.	Water	189-194	alcohol dehydrogenase iron containing 1	Homo sapiens	185-188
33157952-1	2020	RATIONALE: Neuromyelitis optica spectrum disorder (NMOSD) patients, especially those with anti-aquaporin-4 antibody positivity, a water channel expressed on astrocytes, is often accompanied by autoimmune diseases (ADs) including Sjogren syndrome (SS).	Water	130-135	aquaporin 4	Homo sapiens	95-106
32818433-3	2020	Here, we designed and engineered water-soluble, Fzd subtype-specific "next-generation surrogate" (NGS) Wnts that hetero-dimerize Fzd and Lrp6.	Water	33-38	LDL receptor related protein 6	Homo sapiens	137-141
32593472-3	2020	Ifng-/-Il17a-/- mice were fully susceptible to EAU with a characteristic eosinophilic ocular infiltrate, as opposed to a mononuclear infiltrate in WT mice.	Water	47-50	interleukin 17A	Mus musculus	7-12
32593472-5	2020	In EAU-challenged Ifng-/-Il17a-/- mice, ocular infiltrates contained increased GM-CSF-producing CD4+ T cells, and supernatants of retinal antigen-stimulated splenocytes contained enhanced levels of GM-CSF that contributed to activation and migration of eosinophils in vitro.	Water	3-6	interleukin 17A	Mus musculus	25-30
32593472-5	2020	In EAU-challenged Ifng-/-Il17a-/- mice, ocular infiltrates contained increased GM-CSF-producing CD4+ T cells, and supernatants of retinal antigen-stimulated splenocytes contained enhanced levels of GM-CSF that contributed to activation and migration of eosinophils in vitro.	Water	3-6	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	79-85
32593472-5	2020	In EAU-challenged Ifng-/-Il17a-/- mice, ocular infiltrates contained increased GM-CSF-producing CD4+ T cells, and supernatants of retinal antigen-stimulated splenocytes contained enhanced levels of GM-CSF that contributed to activation and migration of eosinophils in vitro.	Water	3-6	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	198-204
32593472-6	2020	Systemic or local blockade of GM-CSF ameliorated EAU in Ifng-/-Il17a-/- mice, reduced eosinophil peroxidase levels in the eye and in the serum and decreased eosinophil infiltration to the eye.	Water	49-52	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	30-36
33139673-3	2020	Zolest-bet ash in pure water shrank the mixture by 0.19 mm/m by the end of the hardening period, and it gave a linear expansion of 0.23 mm/m in a Na2SO4 solution after hardening.	Water	23-28	bet	Drosophila melanogaster	7-10
32783141-1	2020	Aquaporin-4 (AQP4) is located mainly in the astrocytic end-feet around cerebral blood vessels and regulates ion and water homeostasis in the brain.	Water	116-121	aquaporin 4	Mus musculus	0-11
32783141-1	2020	Aquaporin-4 (AQP4) is located mainly in the astrocytic end-feet around cerebral blood vessels and regulates ion and water homeostasis in the brain.	Water	116-121	aquaporin 4	Mus musculus	13-17
32574922-8	2020	IMI and its degradates were found in the tap water samples treated conventionally (range: 1.17-32.0 ng/L for IMI; 0.57-7.00 ng/L for DN-IMI; 0.58-4.50 ng/L for IMI-urea; 0.04-0.65 ng/L for DN-IMI-olefin; < method detection limit [MDL]-0.80 ng/L for IMI-olefin; < MDL-0.35 ng/L for 5-OH-IMI).	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
33312665-0	2020	Health risk assessment of selected metals through tap water consumption in Upper Silesia, Poland.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
33078936-0	2020	Chemical Activation of Water Molecule by Collision with Spin-Orbit-State-Selected Vanadium Cation: Quantum-Electronic-State Control of Chemical Reactivity.	Water	23-28	spindlin 1	Homo sapiens	56-60
33078936-1	2020	We have obtained absolute integral cross sections (sigma"s) for the reactions of spin-orbit-state-selected vanadium cations, V+[a5DJ(J = 0, 2), a5FJ(J = 1, 2), and a3FJ(J = 2, 3)], with a water molecule (H2O) in the center-of-mass collision energy range Ecm = 0.1-10.0 eV.	Water	188-193	spindlin 1	Homo sapiens	81-85
33078936-1	2020	We have obtained absolute integral cross sections (sigma"s) for the reactions of spin-orbit-state-selected vanadium cations, V+[a5DJ(J = 0, 2), a5FJ(J = 1, 2), and a3FJ(J = 2, 3)], with a water molecule (H2O) in the center-of-mass collision energy range Ecm = 0.1-10.0 eV.	Water	204-207	spindlin 1	Homo sapiens	81-85
33138259-7	2020	A linear gradient elution of acetonitrile in water allowed TRP analysis in 8.0 min.	Water	45-50	transient receptor potential cation channel subfamily C member 5	Bos taurus	59-62
33114186-10	2020	Anti-inflammatory IL-10 increased at 8 h in PRO, while it decreased in CHO and H2O.	Water	79-82	interleukin 10	Homo sapiens	18-23
33012165-5	2020	By comparing BaTi(IO3)6 0.5H2O with the centrosymmetric (CS) alpha- and beta-BaTi(IO3)6 that were reported before, it can be found that the bound water plays an important role for the formation of NCS structure for BaTi(IO3)6 0.5H2O.	Water	146-151	chorionic somatomammotropin hormone 1	Homo sapiens	40-66
33178669-5	2020	The DCP/acellular tissue matrix (DCP/ATM) scaffold demonstrated porous structure with porosity over 65% and great capability of absorbing water and other biologics.	Water	138-143	ATM serine/threonine kinase	Rattus norvegicus	37-40
32554142-6	2020	FINDINGS: The PAM/Alginate DN hydrogel not only possesses better stability in water as well as improved mechanical properties and higher coefficients of friction than AF but also can provide similar ultrasound image quality as AF does.	Water	78-83	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	14-17
32955890-6	2020	Molecular dynamics simulations showed that one opening of the cavity in the syn-isomer was widened because of the repulsion between the four COO- charges, which allowed more water molecules to access the hydrophobic cavity than in the case of the anti-isomer.	Water	174-179	synemin	Homo sapiens	76-79
32931478-5	2020	Genetic ablation of TRPV4 resulted in reduced expression of the water conducting aquaporin-5 (AQP-5) channel in ATI cells.	Water	64-69	aquaporin 5	Mus musculus	81-92
32931478-5	2020	Genetic ablation of TRPV4 resulted in reduced expression of the water conducting aquaporin-5 (AQP-5) channel in ATI cells.	Water	64-69	aquaporin 5	Mus musculus	94-99
32599481-7	2020	Hence enhanced water solubility and photostability of Zn-TPP, which are considered as the first two hurdles for the wide usage of porphyrins, were achieved simultaneously by the development of GroEL cage as a building block.	Water	15-20	heat shock protein family D (Hsp60) member 1	Homo sapiens	193-198
32758933-0	2020	Associations between UK tap water and gut microbiota composition suggest the gut microbiome as a potential mediator of health differences linked to water quality.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
32758933-0	2020	Associations between UK tap water and gut microbiota composition suggest the gut microbiome as a potential mediator of health differences linked to water quality.	Water	148-153	nuclear RNA export factor 1	Homo sapiens	24-27
32758933-1	2020	Tap water composition has been widely linked to differences in human health, however the biological pathways underlying this association are less clearly defined.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
32758933-9	2020	These results support the hypothesis that the gut microbiota could mediate the effects of tap water composition on host health, warranting further investigation into tap-water as an influencer of microbiota composition.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
32758933-9	2020	These results support the hypothesis that the gut microbiota could mediate the effects of tap water composition on host health, warranting further investigation into tap-water as an influencer of microbiota composition.	Water	170-175	nuclear RNA export factor 1	Homo sapiens	166-169
33117813-14	2020	An increased level of Pchlide (pif1) resulted in the substantial shift of the structural balance between outer and inner PLB water channels and overall PLB compactness compared to wild type plants.	Water	125-130	phytochrome interacting factor 3-like 5	Arabidopsis thaliana	31-35
33195405-8	2020	This could be explained by the presence of water alkalinity or bicarbonate ions in tap water, which can scavenge free radicals and reduce Hb oxidation/oligomerization.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	83-86
33195405-8	2020	This could be explained by the presence of water alkalinity or bicarbonate ions in tap water, which can scavenge free radicals and reduce Hb oxidation/oligomerization.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
33195405-9	2020	Therefore, it was concluded that Hb could best withstand high concentrations of ozone in the presence of the undiluted 50 mM phosphate buffer followed by phosphate buffer diluted with tap water, containing bicarbonate ions.	Water	188-193	nuclear RNA export factor 1	Homo sapiens	184-187
32935698-5	2020	The excellent catalyst activity and stability merits of P-CoMoO4/NF are comparable to the reported highly efficient non-precious metal HER electrocatalysts and could be applied as a powerful electrocatalyst in water electrolysis.	Water	210-215	neurofascin	Homo sapiens	56-67
32897055-7	2020	We validate our methods by demonstrating the measurement of the acidity of fruit-flavored drinks, the alkalinity of tap water and the carboxylate content of nanocellulose dispersions.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
32969214-2	2020	In the solid state, 2 assembles into a stable halide-metal-organic material (Hal-MOM-2), which catalyzes H2O oxidation under photo- and electrocatalytic conditions, operating with a maximum TON = 78 and TOF = 1.26 s-1.	Water	105-108	ATP synthase F1 subunit alpha	Homo sapiens	81-86
17425115-4	2007	Distilled water and lower boron concentrations (0.1 and 1 mM) increased polyphenol oxidase activities at the beginning of germination up to 12 h whereas its excess levels (10 and 20 mM) decreased polyphenol oxidase activities in embryos and endosperm during germination.	Water	10-15	Polyphenol oxidase, chloroplastic	Zea mays	72-90
33023196-7	2020	The solubility of the alpha-M/HP-beta-CD CX in water linearly increased about 11.7-fold compared to alpha-M alone, and by 3.5-fold compared to the alpha-M/HP-beta-CD physical mixture (alpha-M/HP-beta-CD CX PM).	Water	47-52	adrenomedullin	Mus musculus	22-29
33023196-7	2020	The solubility of the alpha-M/HP-beta-CD CX in water linearly increased about 11.7-fold compared to alpha-M alone, and by 3.5-fold compared to the alpha-M/HP-beta-CD physical mixture (alpha-M/HP-beta-CD CX PM).	Water	47-52	adrenomedullin	Mus musculus	100-107
33023196-7	2020	The solubility of the alpha-M/HP-beta-CD CX in water linearly increased about 11.7-fold compared to alpha-M alone, and by 3.5-fold compared to the alpha-M/HP-beta-CD physical mixture (alpha-M/HP-beta-CD CX PM).	Water	47-52	adrenomedullin	Mus musculus	100-107
33023196-7	2020	The solubility of the alpha-M/HP-beta-CD CX in water linearly increased about 11.7-fold compared to alpha-M alone, and by 3.5-fold compared to the alpha-M/HP-beta-CD physical mixture (alpha-M/HP-beta-CD CX PM).	Water	47-52	adrenomedullin	Mus musculus	100-107
17425115-4	2007	Distilled water and lower boron concentrations (0.1 and 1 mM) increased polyphenol oxidase activities at the beginning of germination up to 12 h whereas its excess levels (10 and 20 mM) decreased polyphenol oxidase activities in embryos and endosperm during germination.	Water	10-15	Polyphenol oxidase, chloroplastic	Zea mays	196-214
17425115-6	2007	Further, caffeic acid oxidizing polyphenol oxidase was found to show more activity in embryos of the seeds germinating in distilled water when compared to other substrates.	Water	132-137	Polyphenol oxidase, chloroplastic	Zea mays	32-50
33135034-2	2020	An inversion of phase behavior was observed: while below ~298 K, the miscibility of water in the studied ILs increases according to the order [C2mim][TSAC] < [C2mim][FSI] < [C2mim][NTf2], for temperatures above ~303 K, the reverse trend is observed [C2mim][NTf2] < [C2mim][FSI] < [C2mim][TSAC].	Water	84-89	nuclear transport factor 2	Homo sapiens	181-185
33017311-2	2020	Altering the concentration of piperazine (pip, ancillary ligand) enables control over the dimensionality of the compound by switching between the 0D [H2pip][Hpip][Pr(pydc)3] 4H2O (I) and the 1D {[Pr(pydc)(Hpydc)(H2O)2] 4H2O}n (II) coordination polymer (CP).	Water	175-178	PBX homeobox interacting protein 1	Homo sapiens	157-161
33135034-2	2020	An inversion of phase behavior was observed: while below ~298 K, the miscibility of water in the studied ILs increases according to the order [C2mim][TSAC] < [C2mim][FSI] < [C2mim][NTf2], for temperatures above ~303 K, the reverse trend is observed [C2mim][NTf2] < [C2mim][FSI] < [C2mim][TSAC].	Water	84-89	nuclear transport factor 2	Homo sapiens	257-261
17345743-1	2006	The aerobic oxidation of alcohols in water can be performed efficiently in the presence of a catalytic amount of the water-soluble diruthenium complex Ru2(micro-OAc)3(micro-CO3) under an atmospheric pressure (1 atm) of O2.	Water	37-42	doublecortin domain containing 2	Homo sapiens	151-154
33361995-5	2020	A possible explanation of this agreement between the modeled and measured Cn2 values is that the large air-water temperature differences encountered provided such strong forcing for the NAVSLaM model that any potential violations of the Monin-Obukhov similarity theory assumptions had only a secondary influence on the Cn2 estimates.	Water	107-112	carnosine dipeptidase 2	Homo sapiens	74-77
32565080-10	2020	SIGNIFICANCE: The alternative oxidase is a ubiquinol oxidoreductase enzyme that catalyses the oxidation of ubiquinol and the reduction of oxygen to water.	Water	148-153	acyl-CoA oxidase 1	Homo sapiens	18-37
17345743-1	2006	The aerobic oxidation of alcohols in water can be performed efficiently in the presence of a catalytic amount of the water-soluble diruthenium complex Ru2(micro-OAc)3(micro-CO3) under an atmospheric pressure (1 atm) of O2.	Water	117-122	doublecortin domain containing 2	Homo sapiens	151-154
19810406-7	2006	Irrespective of the method used, the hydrogen bond donor radius increases in the order HF &lt; HCl &lt; H2O &lt; HBr &lt; HCN &lt; HCCH &lt; H2S, but mostly lie between Pauling"s covalent and van der Waals radii of H atom.	Water	104-107	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	122-125
32516669-3	2020	This study aimed to investigate the fluoride concentration in drinking water in CKDu affected areas in Sri Lanka and to evaluate the possible effect of renal impairment on serum fluoride levels in CKDu patients.	Water	71-76	sorcin	Homo sapiens	103-106
32623220-9	2020	Consumers may unknowingly be degrading their indoor air quality when using tap water of acceptable drinking water quality as humidifier fill water.	Water	108-113	nuclear RNA export factor 1	Homo sapiens	75-78
32693277-2	2020	These phenolic compounds are removed from tap water using horseradish roots (Raphanus sativus) that contain peroxidase as catalyst and H2O2 to generate hydroxyl radicals.	Water	46-51	peroxidase E5-like	Raphanus sativus	108-118
33044813-10	2020	Explicitly, we describe a number of processes that can be controlled by the electron"s spin, among them the interaction of chiral molecules with ferromagnetic surfaces, the multielectron oxidation of water, and enantiospecific electrochemistry.	Water	200-205	spindlin 1	Homo sapiens	87-91
17154074-14	2006	7) Water tight dural closure and secure sealing of mastoid cells is necessary to prevent CSF rhinorrhoe.	Water	3-8	colony stimulating factor 2	Homo sapiens	89-92
32810620-0	2020	Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-kappaB and TGF-beta/smads signaling pathways.	Water	20-25	transforming growth factor alpha	Rattus norvegicus	89-97
32673906-12	2020	N-desmethyl-acetamiprid was more likely to be detected in children who drank more tap water.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
32673906-15	2020	Tap water and fresh vegetables were potential sources.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
17125375-1	2006	A highly efficient photocatalytic system for hydrogen evolution with dihydronicotinamide coenzyme (NADH) as a sacrificial agent in an aqueous solution has been constructed by using water-soluble platinum clusters functionalized with methyl viologen-alkanethiol (MVA2+) and a simple electron-donor dyad, 9-mesityl-10-methylacridinium ion (Acr+-Mes), which is capable of fast photoinduced electron transfer but extremely slow back electron transfer.	Water	181-186	acrosin	Homo sapiens	338-341
32772617-2	2020	In at least two-thirds of cases, antibodies against the water channel AQP4 can be found, which lead to an antibody-mediated activation of the complement system with consecutive damage to neuronal structures.	Water	56-61	aquaporin 4	Homo sapiens	70-74
32736070-8	2020	Our data showed that HIF-2alpha overexpression reduced neurological damage scores and brain water content, suggesting it had a protective effect on ICH injury.	Water	92-97	endothelial PAS domain protein 1	Rattus norvegicus	21-31
17107079-0	2006	Stereochemical course in water addition during LUP1-catalyzed triterpene cyclization.	Water	25-30	lupeol synthase 1	Arabidopsis thaliana	47-51
32623163-1	2020	Climate change has been posited as the biggest threat to crop productivity in agro-systems, yet its impact on the water footprints of crop production for many regions remains uncertain.	Water	114-119	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	134-138
32623163-7	2020	Crop water requirements for winter wheat decreased by 4.88%, due to positive and negative trends in humidity and wind speed respectively.	Water	5-10	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	0-4
32623163-9	2020	The cumulative effects of climate change on crop water requirements and wheat yields increased the blue water footprint by 4%.	Water	49-54	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	44-48
32623163-9	2020	The cumulative effects of climate change on crop water requirements and wheat yields increased the blue water footprint by 4%.	Water	104-109	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	44-48
33161479-7	2020	The purpose of this review is to provide an update on recent innovations reported for using hot-melt extrusion and KinetiSol  Dispersing technologies to formulate poorly water-soluble APIs in amorphous solid dispersions.	Water	170-175	alcohol dehydrogenase iron containing 1	Homo sapiens	92-95
33218568-9	2020	CONCLUSION: The results suggest that both mat and water Pilates exercise program have beneficial effects on the treatment of LBP.	Water	50-55	lipopolysaccharide binding protein	Homo sapiens	125-128
32902279-1	2020	Molecular dynamics simulations are used to examine the effect of surface roughness and surface tension on the transfer of the classical hydronium ion (H3O+) across the water/1,2-dichloroethane interface.	Water	168-173	H3 clustered histone 15	Homo sapiens	151-154
16871401-0	2006	Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice.	Water	24-29	PRP@	Bos taurus	151-154
16788141-10	2006	Water diuresis did not change UT-A1 but decreased AQP2 and NKCC2/BSC1 abundances.	Water	0-5	aquaporin 2	Rattus norvegicus	50-54
33167342-1	2020	Aquaporin-4 (AQP4) is critically involved in brain water and volume homeostasis and has been implicated in a wide range of pathological conditions.	Water	51-56	aquaporin 4	Mus musculus	0-11
33167342-1	2020	Aquaporin-4 (AQP4) is critically involved in brain water and volume homeostasis and has been implicated in a wide range of pathological conditions.	Water	51-56	aquaporin 4	Mus musculus	13-17
17385429-0	2006	[Role of Ca2+ and aquaporin-2 in regulation of basolateral water permeability of collecting ducts in the rat kidney].	Water	59-64	aquaporin 2	Rattus norvegicus	18-29
33104135-5	2020	Furthermore, an advanced water-splitting electrolyzer was assembled with NiS/MoO3/NF as both the anodic and cathodic working electrode.	Water	25-30	neurofascin	Homo sapiens	82-84
17385429-1	2006	The role of AQP2,3 and intracellular calcium in vasopressin-induced increase in the water permeability of the basolateral cell membrane in microdissected rat kidney OMCD was studied.	Water	84-89	aquaporin 2	Rattus norvegicus	12-16
17385429-2	2006	It was shown that increase in the water permeability of the basolateral membranes correlated with increase in the content of AQP2 and AQP3 in the membrane fraction isolated from outer kidney medulla.	Water	34-39	aquaporin 2	Rattus norvegicus	125-129
17385429-2	2006	It was shown that increase in the water permeability of the basolateral membranes correlated with increase in the content of AQP2 and AQP3 in the membrane fraction isolated from outer kidney medulla.	Water	34-39	aquaporin 3 (Gill blood group)	Rattus norvegicus	134-138
33139822-4	2020	We designed the PVA/BTCA/beta-CD/GOx/AuNPs NF hydrogels, which exhibit flexibility, biocompatibility, excellent absorptivity (DI water: 21.9 +- 1.9, PBS: 41.91 +- 3.4), good mechanical properties (dried: 12.1 MPa, wetted: 5.33 MPa), and high enzyme activity of 76.3%.	Water	129-134	hydroxyacid oxidase 1	Homo sapiens	33-36
17054360-1	2006	Water-soluble pi-conjugated polymers (CPs) incorporating 5,5"-(2,2"-dipyridyl) (CP1) or 6,6"-(2,2"-dipyridyl) (CP2) units within the pi-conjugated backbone were prepared as scaffolds for macromolecular metal complexation.	Water	0-5	ceruloplasmin	Homo sapiens	111-114
32638301-4	2020	Based on empirical results, first, GRP growth has shown appealing behavior in the form of its heterogeneous impacts on water-based pollutant emissions growth in the case of different regions.	Water	119-124	gastrin releasing peptide	Homo sapiens	35-38
32638301-11	2020	Thirdly, the causal connection between GRP growth and water-based pollutant emissions growth remained very interesting and of mixed nature.	Water	54-59	gastrin releasing peptide	Homo sapiens	39-42
17019031-6	2006	The model indicates that there is a nonzero correction for the NACP chamber in both a graphite and water phantom and that material adjacent to the air cavity has a significant effect on the measured ionization.	Water	99-104	synuclein alpha	Homo sapiens	63-67
32781084-5	2020	These cells were grown as orthotopic tumors in athymic nude mice and PAF1 knockdown was induced by administration of doxycycline in drinking water.	Water	141-146	Paf1, RNA polymerase II complex component	Mus musculus	69-73
17010132-8	2006	RESULTS: Wild-type and ALDH2+/- mice preferred ethanol to water.	Water	58-63	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	23-28
32483881-5	2020	The present study reveals that both water and food deprivations cause oxidative stress and subsequently decrease catalase and superoxide dismutase activity, while these increase malondialdehyde and hydrogen peroxide.	Water	36-41	catalase	Coturnix japonica	113-121
32890602-6	2020	Additionally, results from PCR, fluorescence in situ hybridization, and immunocytochemical analyses showed that GAS5 is mainly expressed in the cytoplasm of hippocampal neural stems cells and promotes their differentiation into neurons; the Morris water maze test demonstrated that GAS5 overexpression restored learning and memory in rats with cholinergic injury.	Water	248-253	growth arrest specific 5	Rattus norvegicus	112-116
17075179-6	2006	The result showed that ZmPIP1-1 was up-regulated under water deficit in root systems of plants of the filial generation "Hudan 4" and the mother line "Tiansi", which were resistant to water shortage, but there was no noticeable up-regulation of ZmPIP1-1 in the root systems of the father line "803", which was sensitive to water deprivation.	Water	55-60	aquaporin PIP1-1	Zea mays	23-31
16986854-9	2006	A proton-transfer process from C5 to O10 is facilitated by explicit H(2)O, which results in enol-keto form intermediate of this modified base (defined as BrU*).	Water	68-73	immunoglobulin kappa variable 3D-31 (pseudogene)	Homo sapiens	37-40
16961380-1	2006	The reaction between aquacobalamin, Cbl(H2O), and NO was studied at low pH.	Water	40-43	Cbl proto-oncogene	Homo sapiens	36-39
16961380-2	2006	As previously reported, the final product of the reaction is the same as that obtained in the reaction of NO and reduced Cbl(H2O), viz.	Water	125-128	Cbl proto-oncogene	Homo sapiens	121-124
16924288-10	2006	DFT studies showed that, in the silver complex 2, coordination of H2O to Ag in the binuclear complex is favoured by formation of a hydrogen-bonding network, involving the triflato anion, and releasing enough energy to allow distortion of the Ag2 framework.	Water	66-69	chromosome 11 open reading frame 96	Homo sapiens	242-245
16939241-5	2006	Here we describe a pair of beta3-peptides whose sequences were designed to promote a 14-helix structure in water, favor hetero-oligomer formation, and disfavor nonspecific aggregation.	Water	107-112	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	27-32
16624991-4	2006	Relative AQP8 single-channel NH(3)-to-water permeability was approximately 0.03.	Water	38-43	aquaporin 8	Mus musculus	9-13
16824752-2	2006	An initial investigation of the novel cyclopentane scaffold 6 afforded low nanomolar human NK1 antagonists having enhanced water solubility properties compared to morpholine 1.	Water	123-128	tachykinin receptor 1	Homo sapiens	91-94
21727561-2	2006	The method is convenient to control and allows the formation of a stable, water-soluble suspension of CdS/aligned-MWCNT heterostructures.	Water	74-79	CDP-diacylglycerol synthase 1	Homo sapiens	102-105
16884307-2	2006	We report here the structures of the water soluble 8-aryl-sulfanyl adenine class Hsp90 inhibitors, 1 (PU-H71) and 2 (PU-H64), in complex with the N-terminal domain of human Hsp90alpha.	Water	37-42	heat shock protein 90 alpha family class A member 1	Homo sapiens	81-86
32998402-1	2020	The water channel protein aquaporin-4 (AQP4) is required for a normal rate of water exchange across the blood-brain interface.	Water	4-9	aquaporin 4	Mus musculus	26-37
16884307-2	2006	We report here the structures of the water soluble 8-aryl-sulfanyl adenine class Hsp90 inhibitors, 1 (PU-H71) and 2 (PU-H64), in complex with the N-terminal domain of human Hsp90alpha.	Water	37-42	heat shock protein 90 alpha family class A member 1	Homo sapiens	173-183
32998402-1	2020	The water channel protein aquaporin-4 (AQP4) is required for a normal rate of water exchange across the blood-brain interface.	Water	4-9	aquaporin 4	Mus musculus	39-43
16487477-4	2006	AQP3, 7, 9, and 10 are subcategorized as aquaglyceroporins which permeabilize glycerol as well as water.	Water	98-103	aquaporin 3 (Gill blood group)	Homo sapiens	0-4
32998402-1	2020	The water channel protein aquaporin-4 (AQP4) is required for a normal rate of water exchange across the blood-brain interface.	Water	78-83	aquaporin 4	Mus musculus	26-37
32998402-1	2020	The water channel protein aquaporin-4 (AQP4) is required for a normal rate of water exchange across the blood-brain interface.	Water	78-83	aquaporin 4	Mus musculus	39-43
16867144-5	2006	Only a few terminal restriction fragments dominated the denitrifier communities throughout the water column, and these could be assigned to several new Baltic Sea clusters that were revealed by phylogenetic analysis.	Water	95-100	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	159-162
33088168-3	2020	Methods: EAU was induced in B10.A mice with immunization with bovine interphotoreceptor retinoid-binding protein (IRBP), emulsified in complete Freund"s adjuvant (CFA), and a simultaneous injection of pertussis toxin.	Water	9-12	retinol binding protein 3	Bos taurus	69-112
33088168-3	2020	Methods: EAU was induced in B10.A mice with immunization with bovine interphotoreceptor retinoid-binding protein (IRBP), emulsified in complete Freund"s adjuvant (CFA), and a simultaneous injection of pertussis toxin.	Water	9-12	retinol binding protein 3	Bos taurus	114-118
16835867-0	2006	Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells.	Water	9-14	adiponectin, C1Q and collagen domain containing	Mus musculus	60-71
32883079-7	2020	The assembly of Al4 polyanions with equivalent Ln ions afforded a series of zigzag chain structures [LnAl4(L)4(Cat)2(DMF)2(H2O)3] Hdma (Ln = Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb) (AlOC-13-Ln).	Water	123-126	G antigen 12I	Homo sapiens	16-19
16781078-2	2006	Analysis of the forces in the system comprising AFM tip, water meniscus, and polymer film suggests that an electrostatic repulsion of the tip from the surface in the double-layered (water and polymer) system, and water condensation in the tip-surface junction are the dominant factors enabling the mechanical work for tip retraction.	Water	182-187	TOR signaling pathway regulator	Homo sapiens	138-141
32961928-4	2020	Pathogenic autoantibiotics that target the water channel aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) contribute to NMOSD pathology.	Water	43-48	aquaporin 4	Homo sapiens	70-74
16781078-2	2006	Analysis of the forces in the system comprising AFM tip, water meniscus, and polymer film suggests that an electrostatic repulsion of the tip from the surface in the double-layered (water and polymer) system, and water condensation in the tip-surface junction are the dominant factors enabling the mechanical work for tip retraction.	Water	182-187	TOR signaling pathway regulator	Homo sapiens	138-141
16781078-2	2006	Analysis of the forces in the system comprising AFM tip, water meniscus, and polymer film suggests that an electrostatic repulsion of the tip from the surface in the double-layered (water and polymer) system, and water condensation in the tip-surface junction are the dominant factors enabling the mechanical work for tip retraction.	Water	182-187	TOR signaling pathway regulator	Homo sapiens	138-141
16781078-2	2006	Analysis of the forces in the system comprising AFM tip, water meniscus, and polymer film suggests that an electrostatic repulsion of the tip from the surface in the double-layered (water and polymer) system, and water condensation in the tip-surface junction are the dominant factors enabling the mechanical work for tip retraction.	Water	182-187	TOR signaling pathway regulator	Homo sapiens	138-141
16855083-5	2006	Fos expression was elevated after expression of a remote (1 month old), but not recent (1 d old), water-maze memory, suggesting that ACC plays an increasingly important role as a function of time.	Water	98-103	FBJ osteosarcoma oncogene	Mus musculus	0-3
32845641-2	2020	Ul-tra-confinement of the water molecule can remove H-bonding, leaving only molecular water.	Water	26-31	T cell receptor alpha locus	Homo sapiens	3-6
32845641-2	2020	Ul-tra-confinement of the water molecule can remove H-bonding, leaving only molecular water.	Water	86-91	T cell receptor alpha locus	Homo sapiens	3-6
16545834-3	2006	It was observed that HNOA-1, being in lack of second aromatic ring, formed multilayer films at the air/water interface, while the other two compounds, with another aromatic ring and some hydrophilic groups, can be spread as monolayers on water surface.	Water	103-108	nitric oxide associated 1	Homo sapiens	21-27
32940115-4	2021	Fluoride content in youth"s household tap water samples was measured electrometrically with ion-specific electrodes and designated low (<0.6 mg/L) or about optimal (0.6 to 1.2 mg/L).	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
16800661-2	2006	Their study by SANS, FT-IR, and 1H NMR for this composition has shown remarkable effects of the isotopic nature of water on their structural and dynamic properties.	Water	115-120	USH1 protein network component sans	Homo sapiens	15-19
32940115-6	2021	We used binomial regression models to estimate adjusted prevalence ratios (APRs) and 95% CIs for consuming plain tap water (including tap only or both tap and bottled) and consuming only bottled water as related to household water fluoride content (low or about optimal) and sociodemographic characteristics.	Water	117-122	nuclear RNA export factor 1	Homo sapiens	113-116
32940115-11	2021	CONCLUSION: Half of youth consumed plain tap water on a given day.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
32940115-14	2021	KNOWLEDGE TRANSFER STATEMENT: Half of US youth consumed plain tap water on a given day.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
32940115-17	2021	Our findings add support for the need to identify and address barriers to tap water consumption and promote health benefits of fluoridation.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
16800661-3	2006	By SANS, between 38 and 43.5 degrees C, micelles appear as either flexible polymer-like cylinders or short rods depending on whether water is H2O or D2O.	Water	133-138	USH1 protein network component sans	Homo sapiens	3-7
16800661-3	2006	By SANS, between 38 and 43.5 degrees C, micelles appear as either flexible polymer-like cylinders or short rods depending on whether water is H2O or D2O.	Water	142-145	USH1 protein network component sans	Homo sapiens	3-7
32840552-5	2020	Moreover, the calculation of adsorption energies on mixed-cation Cs1-xFAxPbI3(001) surfaces reveals that the much stronger adsorption strength of 3-butenoic acid facilitates blocking of the interaction of surfaces with water molecules.	Water	219-224	chorionic somatomammotropin hormone 1	Homo sapiens	65-68
32622948-0	2020	Phospholipase Cbeta3 in the hippocampus may mediate impairment of memory by long-term blockade of orexin 1 receptors assessed by the Morris water maze.	Water	140-145	phospholipase C beta 3	Rattus norvegicus	0-20
16800661-5	2006	In addition, when water contains more than 40% of D2O, a Bragg reflection emerges at 0.12 A(-1) on SANS spectra, evidencing an organization of micelles.	Water	18-23	USH1 protein network component sans	Homo sapiens	99-103
16787232-4	2006	Considerable evidence has accumulated that implicates both galanin and GALP as playing important roles in regulating food and water intake behavior and related neuroendocrine functions.	Water	126-131	galanin like peptide	Homo sapiens	71-75
32933292-1	2020	The self-diffusion coefficient of water shows an anomalous increase with increasing hydrostatic pressure up to a broad maximum (PmD) near 1 kbar at 298 K, which has been attributed to pressure effects on the tetrahedral hydrogen bond network of water.	Water	34-39	proteolipid protein 1	Homo sapiens	128-131
32933292-1	2020	The self-diffusion coefficient of water shows an anomalous increase with increasing hydrostatic pressure up to a broad maximum (PmD) near 1 kbar at 298 K, which has been attributed to pressure effects on the tetrahedral hydrogen bond network of water.	Water	245-250	proteolipid protein 1	Homo sapiens	128-131
16759981-6	2006	OGG1 expression levels were linked to As concentrations in drinking water and nails, selenium concentrations in nails, and skin hyperkeratosis.	Water	68-73	8-oxoguanine DNA glycosylase	Homo sapiens	0-4
32917102-6	2021	The mean lead concentration in tap water was 8.3 parts per billion, with 6% of sample testing above the Environmental Protection Agency"s action level.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
32315938-0	2020	TLR4-MyD88 signaling pathway is responsible for acute lung inflammation induced by reclaimed water.	Water	93-98	myeloid differentiation primary response gene 88	Mus musculus	5-10
32315938-6	2020	In general, this study demonstrated that the TLR4-MyD88 signaling pathway is responsible for the acute lung inflammation induced by reclaimed water, which excludes the possibility of other signaling pathway dependent inflammation inducers in reclaimed water.	Water	142-147	myeloid differentiation primary response gene 88	Mus musculus	50-55
16759981-7	2006	OGG1 expression was strongly associated with water As concentrations (p &lt; 0.0001).	Water	45-50	8-oxoguanine DNA glycosylase	Homo sapiens	0-4
16759981-9	2006	The maximal OGG1 response was at the water As concentration of 149 microg/L.	Water	37-42	8-oxoguanine DNA glycosylase	Homo sapiens	12-16
32879313-2	2020	This fluid transport system is supported by the water channel aquaporin-4 (AQP4) localized to vascular endfeet of astrocytes.	Water	48-53	aquaporin 4	Mus musculus	75-79
16819982-8	2006	Kir4.1, a potassium channel protein linked to water flux, exhibited enhanced immunoreactivity in the cerebral cortex of hydrocephalic rats; the perineuronal distribution was entirely different from that of AQP4.	Water	46-51	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	0-6
31818185-10	2020	CASP9 expression or exogenously added H2O2 in the CASP9 KO cells corrected the ATG3 level and lipidation status of Atg8-family members, and restored autophagy flux.	Water	38-42	autophagy related 3	Homo sapiens	79-83
32889490-7	2020	However, sAA activity in diluted samples decreased in plastic containers (PS, PP), or if ultra-pure water was used as the diluent.	Water	100-105	serum amyloid A1 cluster	Homo sapiens	9-12
16609960-1	2006	alpha-Syntrophin, a member of the dystrophin-associated protein complex, is required for proper localization of the water channel aquaporin-4 at the blood-brain barrier.	Water	116-121	dystrophin	Homo sapiens	34-44
32853485-9	2020	The ROCK2, PMVK, ADCY2, MAP2K6, BMP10 and GFPT1 genes are main candidates for reproductive traits in water dairy buffaloes and, these results may have future applications in animal breeding programs or in gene expression studies of the species.	Water	101-106	adenylate cyclase type 2	Bubalus bubalis	17-22
32853485-9	2020	The ROCK2, PMVK, ADCY2, MAP2K6, BMP10 and GFPT1 genes are main candidates for reproductive traits in water dairy buffaloes and, these results may have future applications in animal breeding programs or in gene expression studies of the species.	Water	101-106	BMP10	Bubalus bubalis	32-37
32853485-9	2020	The ROCK2, PMVK, ADCY2, MAP2K6, BMP10 and GFPT1 genes are main candidates for reproductive traits in water dairy buffaloes and, these results may have future applications in animal breeding programs or in gene expression studies of the species.	Water	101-106	glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	Bubalus bubalis	42-47
32681852-2	2020	Aquaporin 4 (AQP4), the predominant water channel exists in astrocytes, has been proved to modulate astrocytic function and thus participate in many diseases of the central nervous system.	Water	36-41	aquaporin 4	Mus musculus	0-11
32681852-2	2020	Aquaporin 4 (AQP4), the predominant water channel exists in astrocytes, has been proved to modulate astrocytic function and thus participate in many diseases of the central nervous system.	Water	36-41	aquaporin 4	Mus musculus	13-17
16768129-5	2006	Recently, AQP4 and AQP9 have been reported to involve in the brain water accumulation in the brain edema.	Water	67-72	aquaporin 9	Mus musculus	19-23
32957290-0	2020	Effects of ascorbate and carbonate on the conversion and developmental toxicity of halogenated disinfection byproducts during boiling of tap water.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	137-140
32957290-2	2020	Humans are unavoidably exposed to halogenated DBPs via tap water ingestion.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
32957290-3	2020	Boiling of tap water has been found to significantly reduce the concentrations of halogenated DBPs.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
32957290-5	2020	Adding ascorbate removed the chlorine residual in tap water and thus prevented the formation of more halogenated DBPs in the boiling process.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
32957290-6	2020	Adding carbonate elevated pH of tap water and consequently enhanced the hydrolysis (dehalogenation) of halogenated DBPs or led to the formation of more trihalomethanes that might volatilize to air during the boiling process.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
32957290-8	2020	The results showed that adding a tiny amount of sodium ascorbate or carbonate (2.5-5.0 mg/L) to tap water followed by boiling for 5 min reduced the developmental toxicity of tap water to a substantially lower level than boiling only.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
32957290-8	2020	The results showed that adding a tiny amount of sodium ascorbate or carbonate (2.5-5.0 mg/L) to tap water followed by boiling for 5 min reduced the developmental toxicity of tap water to a substantially lower level than boiling only.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	174-177
32957290-8	2020	The results showed that adding a tiny amount of sodium ascorbate or carbonate (2.5-5.0 mg/L) to tap water followed by boiling for 5 min reduced the developmental toxicity of tap water to a substantially lower level than boiling only.	Water	178-183	nuclear RNA export factor 1	Homo sapiens	96-99
32957290-8	2020	The results showed that adding a tiny amount of sodium ascorbate or carbonate (2.5-5.0 mg/L) to tap water followed by boiling for 5 min reduced the developmental toxicity of tap water to a substantially lower level than boiling only.	Water	178-183	nuclear RNA export factor 1	Homo sapiens	174-177
32957290-9	2020	The addition of sodium ascorbate or carbonate to tap water in household could be realized by preparing them in tiny pills.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
32957290-10	2020	This study suggests simple and effective methods to reduce the adverse effects of halogenated DBPs on humans through tap water ingestion.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
32100241-2	2020	The traditional method to control dust problem is to spray roads with tap water.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
32100241-5	2020	In addition, the saved tap water can be used for production and life, thereby obtaining additional benefits.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
32100241-9	2020	The total benefit of using reclaimed water was about 1.30-1.80 times that of using tap water, and the net benefit was 4.65-7.17 times.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
32717657-5	2020	Furthermore, 151 tap water samples from 51 locations range between 0.70404 to 0.71385 (DeltaSrmax-min=0.00981).	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
32717657-6	2020	Overall, small variations in the hair and tap water samples collected from individual locations were recorded (DeltaSrmax-min=0.00041 and 0.00034 respectively).	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
32717657-7	2020	Despite the fact that Mexico is one of the largest bottled water consumers in the world, the 87Sr/86Sr ratios of human hair and tap water correlated strongly (R2=0.87 for location averages and R2=0.80 when using individual data points).	Water	132-137	nuclear RNA export factor 1	Homo sapiens	128-131
31975412-6	2020	H19 knockdown abrogated the H2 O2 -PC-mediated protection in cardiomyocytes evidenced by the decreased cell viability and increased caspase-3 activity.	Water	28-33	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	0-3
31975412-7	2020	Conversely, H19 overexpression enhanced the protective role of H2 O2 -PC in cardiomyocytes.	Water	63-68	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	12-15
31975412-8	2020	In addition, H19 overexpression increased the expression of nucleolin, whereas H19 ablation abrogated H2 O2 -PC-induced upregulation of nucleolin in cardiomyocytes.	Water	102-107	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	79-82
32994008-12	2020	The surface wettability test exhibited decreased water contact angle measurement from 126  for pure PCL to 93  for the PCL/PPy-200 composite scaffold.	Water	49-54	polycystic kidney disease 2-like 1	Mus musculus	119-122
32633604-4	2020	In susceptible beans, Pph causes water-soaking at the site of infection and produces phaseolotoxin, an inhibitor of bean arginine biosynthesis.	Water	33-38	brain expressed associated with NEDD4 1	Homo sapiens	15-19
32535322-9	2020	The content of HSP-70 and the corresponding gene expression level were significantly reduced by elevated [CO2], irrespective of water treatments.	Water	128-133	heat shock 70	Glycine max	15-21
32438177-4	2020	Results showed that there are clearly two distinct seasons in the consumption of water: a low season (from November to August, sensu lato), with reduced consumptions, and a high season, corresponding to the harvest/first racking period (September/October), a period in which water consumption is multiplied by a factor 2-3 in the smallest wineries, or by a factor 5 in the larger ones.	Water	81-86	transcription termination factor 2	Homo sapiens	312-322
32843684-1	2020	The water channel aquaporin 4 (AQP4) regulates the flux of water across the cell membrane, maintaining cellular homeostasis.	Water	4-9	aquaporin 4	Mus musculus	31-35
32843684-1	2020	The water channel aquaporin 4 (AQP4) regulates the flux of water across the cell membrane, maintaining cellular homeostasis.	Water	59-64	aquaporin 4	Mus musculus	31-35
32678616-3	2020	(H2O)n (n=1,2,3) were first optimized at the MP2/6-311++G(d,p) and B3LYP-D3BJ/def2-TZVP levels of theory.	Water	1-4	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	69-72
32641606-5	2020	Here, sn-2-PUFA-monoacylglycerol (MAG) was extracted from the reaction solution using a mixture of hexane and ethanol/water (70:30, v/v) to produce high-purity sn-2-PUFA-MAG with 78.1 % yield.	Water	118-123	pumilio RNA binding family member 3	Homo sapiens	11-15
32748925-8	2020	Efficient sensing of both Cr6+ and Fe3+ in various real-life water samples along with a real wastewater sample is also reported herein.	Water	61-66	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	26-29
32701304-1	2020	Reactions of SnX2 (X = Cl, Br) with [PtMe2(bipy)], 1, (bipy = 2,2"-bipyridine), followed by NaBH4 reduction at the toluene/water interface in the presence or absence of graphene oxide support rendered PtSn nanoalloy thin films.	Water	123-128	sorting nexin 2	Homo sapiens	13-17
32380273-1	2020	Aquaporin-4 (AQP4), an astrocyte water channel protein, is the target antigen of serum immunoglobulin G (IgG) autoantibody in neuromyelitis optica spectrum disorders (NMOsd), a group of inflammatory, demyelinating diseases of the central nervous system.	Water	33-38	aquaporin 4	Homo sapiens	0-11
32380273-1	2020	Aquaporin-4 (AQP4), an astrocyte water channel protein, is the target antigen of serum immunoglobulin G (IgG) autoantibody in neuromyelitis optica spectrum disorders (NMOsd), a group of inflammatory, demyelinating diseases of the central nervous system.	Water	33-38	aquaporin 4	Homo sapiens	13-17
32337861-6	2020	For both cases and controls, the saliva NGAL concentration decreased significantly after cleansing the mouth with tap water (cases p = .01; controls p = .01).	Water	118-123	lipocalin 2	Homo sapiens	40-44
32220691-1	2020	The present work reported a high-throughput strategy for the analysis of 21 perfluorinated compounds (PFCs) in drinking water, tap water, river water and plant effluent from southern China by supramolecular solvent (SUPARS) vortex-mixed microextraction combined with high performance liquid chromatography-Orbitrap high resolution mass spectrometry (HPLC-Orbitrap HRMS).	Water	131-136	nuclear RNA export factor 1	Homo sapiens	127-130
30681405-6	2020	Furthermore, the temperature and concentration of both the draw and feed solutions played a significant role in increasing the water flux, which could be interpreted in terms of the mass transfer coefficient representing ECP; a factor sensitive to the hydraulics of the system.	Water	127-132	ribonuclease A family member 3	Homo sapiens	221-224
32430919-1	2020	Microplastics are ubiquitous in our environment and are found in rivers, streams, oceans, and even tap water.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
32484124-0	2020	The Legionella contamination of tap water in a brand-new hospital in Japan before patients move in.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
32736375-3	2020	At PTB, a new water calorimeter has been designed which is capable to determine Dw,Q in an MR-linac.	Water	14-19	polypyrimidine tract binding protein 1	Homo sapiens	3-6
32666781-0	2020	Multistep Surface Trap State Finishing Based on in Situ One-Step MOF Modification over Hematite for Dramatically Enhanced Solar Water Oxidation.	Water	128-133	TRAP	Homo sapiens	18-22
32451148-7	2020	The method is applied to multi echo spin echo MRI scans and computes myelin water maps of the whole brain in under 2min, and luminal water maps of the prostate in under 1min.	Water	76-81	spindlin 1	Homo sapiens	36-40
33376963-0	2020	Non-full-length Water-Soluble CXCR4QTY and CCR5QTY Chemokine Receptors: Implication for Overlooked Truncated but Functional Membrane Receptors.	Water	16-21	C-X-C motif chemokine receptor 4	Homo sapiens	30-38
33093467-2	2020	In most patients, NMO is caused by pathogenetic serum IgG autoantibodies to aquaporin 4 (AQP4), the most abundant water-channel protein in the central nervous system.	Water	114-119	aquaporin 4	Homo sapiens	76-87
33093467-2	2020	In most patients, NMO is caused by pathogenetic serum IgG autoantibodies to aquaporin 4 (AQP4), the most abundant water-channel protein in the central nervous system.	Water	114-119	aquaporin 4	Homo sapiens	89-93
33193542-10	2020	Cumulative CO2 assimilation in ST-OX and epf1 was 57.6 and 78.8% higher than WT attributable to faster A induction with reduction of water use efficiency (WUE).	Water	133-138	epidermal patterning factor 1	Arabidopsis thaliana	41-45
32991151-4	2020	Specifically, the optimized FeCoMnNi-MOF-74/NF with a multilevel and hollow nanostructure was successfully fabricated and used as highly efficient bifunctional electrocatalysts for water splitting.	Water	181-186	neurofascin	Homo sapiens	44-46
32991151-8	2020	1.62 V was obtained at a current density of 10 mA cm-2, when tetrametallic FeCoMnNi-MOF-74/NF is employed as both anode and cathode electrodes for the real water splitting.	Water	156-161	neurofascin	Homo sapiens	91-93
32969225-4	2020	Besides, this polymer nanoprobe (SPN) displays high water dispersibility, ultrafast response (< 1 s), favorable selectivity, outstanding long-term stability (>90 days) and good biocompatibility.	Water	52-57	DEAF1 transcription factor	Homo sapiens	33-36
32991140-4	2020	The dual polymer nanofiber and CNF network are beneficial to the chemical vapor or liquid diffusion into the membrane and thus can be used for high-performance chemical vapor sensing and oil/water separation.	Water	191-196	NPHS1 adhesion molecule, nephrin	Homo sapiens	31-34
33053654-8	2020	The combination of these characteristics within a water-soluble SCPN is highly desirable and could potentially be applied in a wide range of biomedical fields.	Water	50-55	carboxypeptidase N subunit 1	Homo sapiens	64-68
33039542-1	2020	CHROMagar Enterococcus (CHR), a new chromogenic medium not yet available for commercial purchase, was evaluated for the isolation of Enterococcus from environmental water samples.	Water	165-170	chromate resistance; sulfate transport	Homo sapiens	0-3
32897695-4	2020	Molecular modeling revealed that water-mediated hydrogen-bond formation between 3-OH of nalfurafine and KOR accounted for its higher KOR potency than 42B.	Water	33-38	opioid receptor, kappa 1	Mus musculus	104-107
32897695-4	2020	Molecular modeling revealed that water-mediated hydrogen-bond formation between 3-OH of nalfurafine and KOR accounted for its higher KOR potency than 42B.	Water	33-38	opioid receptor, kappa 1	Mus musculus	133-136
33020501-4	2020	Here, we present evidence that during a three-day learning session in the Morris water maze task a genetic knockout model of adult neurogenesis (Cyclin D2-/-) showed changes in sleep macro- and microstructure.	Water	81-86	cyclin D2	Mus musculus	145-154
32755465-6	2020	The data demonstrate that treatment of larvae with acidic water for 4 days postfertilization caused cell-specific increases in H+-ATPase (atp6v1aa), ca17a, ca15a, nhe3b, and rhcgb mRNA in addition to increases in mRNA linked to cell proliferation.	Water	58-63	ATPase H+ transporting V1 subunit Aa	Danio rerio	138-146
32755465-6	2020	The data demonstrate that treatment of larvae with acidic water for 4 days postfertilization caused cell-specific increases in H+-ATPase (atp6v1aa), ca17a, ca15a, nhe3b, and rhcgb mRNA in addition to increases in mRNA linked to cell proliferation.	Water	58-63	solute carrier family 9 member A3, tandem duplicate 2	Danio rerio	163-168
32932041-5	2020	The wastewater from high-pressure water blasting (WHPB) of Ship A (300 tons) and Ship B (5,000 tons) produced a largely overlapping suite of developmental malformations including pericardial edema, spinal curvature, and tail fin defects.	Water	9-14	inositol polyphosphate-5-phosphatase D	Homo sapiens	59-63
32623220-9	2020	Consumers may unknowingly be degrading their indoor air quality when using tap water of acceptable drinking water quality as humidifier fill water.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
32623220-9	2020	Consumers may unknowingly be degrading their indoor air quality when using tap water of acceptable drinking water quality as humidifier fill water.	Water	108-113	nuclear RNA export factor 1	Homo sapiens	75-78
32338812-11	2020	Direct water content measurements for the NP was achieved by normalizing MRI-based spin density by NP mass density (1.10 +- 0.03 g/cm3 ).	Water	7-12	spindlin 1	Homo sapiens	83-87
32338812-13	2020	DATA CONCLUSION: Spin density or spin density normalized by mass density to estimate NP and AF water content was more accurate than correlations between water content and relaxation times.	Water	95-100	spindlin 1	Homo sapiens	17-21
32768575-1	2020	AIMS: Astrocytes expressing the aquaporin-4 (AQP4) water channel are pathogenic, disease specific immunoglobulins (IgG) found in neuromyelitis optica spectrum disorder (NMOSD), referred to as NMO-IgG, which targets astrocytic AQP4.	Water	51-56	aquaporin 4	Homo sapiens	32-43
32768575-1	2020	AIMS: Astrocytes expressing the aquaporin-4 (AQP4) water channel are pathogenic, disease specific immunoglobulins (IgG) found in neuromyelitis optica spectrum disorder (NMOSD), referred to as NMO-IgG, which targets astrocytic AQP4.	Water	51-56	aquaporin 4	Homo sapiens	45-49
32768575-1	2020	AIMS: Astrocytes expressing the aquaporin-4 (AQP4) water channel are pathogenic, disease specific immunoglobulins (IgG) found in neuromyelitis optica spectrum disorder (NMOSD), referred to as NMO-IgG, which targets astrocytic AQP4.	Water	51-56	aquaporin 4	Homo sapiens	226-230
32678928-0	2020	Phosphorylation influences water and ion channel function of AtPIP2;1.	Water	27-32	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	61-69
32678928-2	2020	Here, we investigated whether the phosphorylation state of S280 and S283 also influence AtPIP2;1 facilitated water and cation transport.	Water	109-114	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	88-94
32678928-4	2020	In Xenopus laevis oocytes, phosphomimic mutants AtPIP2;1 S280D, S283D, and S280D/S283D had significantly greater ion conductance for Na+ and K+ , whereas the S280A single phosphonull mutant had greater water permeability.	Water	202-207	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	48-54
32678928-5	2020	We observed a phosphorylation-dependent inverse relationship between AtPIP2;1 water and ion transport with a 10-fold change in both.	Water	78-83	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	69-75
32678928-6	2020	The results revealed that phosphorylation of S280 and S283 influences the preferential facilitation of ion or water transport by AtPIP2;1.	Water	110-115	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	129-137
33133067-8	2020	C-IRIS mice also exhibited brain swelling with resemblance to edema and upregulation of aquaporin-4, a critical protein that regulates water flux in the brain in a Th1-dependent fashion.	Water	135-140	aquaporin 4	Mus musculus	88-99
32909567-4	2020	The MoS2/SnO2/CNF shows desirable bubble phobicity under water and in a PAO4 environment on various substrates, an acceptable gas-sensing ability to target gas with a detection limit of 5 ppm and fascinating tribological performances for additives in different kinds of base/lubricating oils.	Water	57-62	NPHS1 adhesion molecule, nephrin	Homo sapiens	14-17
32804482-5	2020	Rheology of the suspensions shows a hundredfold increase in storage and loss moduli of CNF-IL-water suspensions as compared to their CNF-water counterparts.	Water	94-99	NPHS1 adhesion molecule, nephrin	Homo sapiens	87-90
32645579-3	2020	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.	Water	181-186	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	176-179
32881954-1	2020	BACKGROUND: Neuromyelitis optica spectrum disorders (NMOSD) is a primary astrocytopathy driven by antibodies directed against the aquaporin-4 water channel located at the end-feet of the astrocyte.	Water	142-147	aquaporin 4	Homo sapiens	130-141
32945844-0	2020	Changes to Zonular Tension Alters the Subcellular Distribution of AQP5 in Regions of Influx and Efflux of Water in the Rat Lens.	Water	106-111	aquaporin 5	Rattus norvegicus	66-70
32945844-2	2020	We have mapped the subcellular distribution of the lens aquaporins (AQP0, AQP1, and AQP5) in these water influx and efflux zones and investigated how their membrane location is affected by changes in tension applied to the lens by the zonules.	Water	99-104	aquaporin 5	Rattus norvegicus	84-88
32945844-8	2020	Conclusions: Altering zonular tension dynamically regulates the membrane trafficking of AQP5 in the efflux and anterior influx zones to potentially change the magnitude of circulating water fluxes in the lens.	Water	184-189	aquaporin 5	Rattus norvegicus	88-92
32662596-8	2020	It was successfully applied to detect trace polycyclic aromatic hydrocarbons in some real water samples, including tap water, snow water and domestic sewage.	Water	90-95	nuclear RNA export factor 1	Homo sapiens	115-118
32722467-3	2020	This study shows that after the aeration and the oxidation with Cl2 and H2O2, the increasing content of dissolved hydrophilic organic substances containing aromatic rings in the raw water reduced the effectiveness of Fe(II) oxidation and the effectiveness of iron removal during the sedimentation process.	Water	182-187	endogenous retrovirus group W member 5	Homo sapiens	64-67
32703841-1	2020	A potentially therapeutic Twort-like myophage, Esa1, with specificity toward Staphylococcus aureus was isolated from lake water.	Water	122-127	lysine acetyltransferase 5	Homo sapiens	47-51
32717858-1	2020	The synthesis of three water-soluble lactose-modified 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based photosensitizers with tumor-targeting capabilities is reported, including an investigation into their photodynamic therapeutic activity on three distinct cancer cell lines (human hepatoma Huh7, cervical cancer HeLa, and breast cancer MCF-7 cell lines).	Water	23-28	MIR7-3 host gene	Homo sapiens	300-304
32608963-4	2020	The vast number of hydrophilic hydroxyl groups on the surface of CNF and paper fibers enables fast water molecules exchange between the humidity sensitive material and the external environment via hydrogen bonding, endowing the paper-based sensor with an excellent humidity responsive property.	Water	99-104	NPHS1 adhesion molecule, nephrin	Homo sapiens	65-68
16359754-9	2006	The present study has shown the wide expression of AM2/IMD in human hypothalamus, heart and kidney, raising the possibility that this novel peptide may be related to the central and peripheral regulation of the circulation and water-electrolyte metabolism.	Water	227-232	adrenomedullin 2	Homo sapiens	51-58
32589018-6	2020	As a proof-of-concept, when the m-TiO2-x NFM is employed to purify practical river water in evaporation prototype under real solar irradiation, complex volatile natural organic contaminations can be effectively intercepted, and the produced distilled water meet the drinking water standards of China.	Water	83-88	neurofilament medium chain	Homo sapiens	41-44
32589018-6	2020	As a proof-of-concept, when the m-TiO2-x NFM is employed to purify practical river water in evaporation prototype under real solar irradiation, complex volatile natural organic contaminations can be effectively intercepted, and the produced distilled water meet the drinking water standards of China.	Water	251-256	neurofilament medium chain	Homo sapiens	41-44
32589018-6	2020	As a proof-of-concept, when the m-TiO2-x NFM is employed to purify practical river water in evaporation prototype under real solar irradiation, complex volatile natural organic contaminations can be effectively intercepted, and the produced distilled water meet the drinking water standards of China.	Water	251-256	neurofilament medium chain	Homo sapiens	41-44
32662596-8	2020	It was successfully applied to detect trace polycyclic aromatic hydrocarbons in some real water samples, including tap water, snow water and domestic sewage.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
32662596-8	2020	It was successfully applied to detect trace polycyclic aromatic hydrocarbons in some real water samples, including tap water, snow water and domestic sewage.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
16551622-6	2006	TEA inhibition was lost upon a Tyr to Phe amino acid switch in the external water pore of AQP1/AQP2/AQP4, whereas the water permeability of AQP3 and AQP5, which lack a corresponding Tyr, was not blocked by TEA.	Water	76-81	aquaporin 2	Homo sapiens	95-99
32582978-1	2020	Aquaporin-4 (AQP4) is a major water channel of the central nervous system.	Water	30-35	aquaporin 4	Homo sapiens	0-11
32582978-1	2020	Aquaporin-4 (AQP4) is a major water channel of the central nervous system.	Water	30-35	aquaporin 4	Homo sapiens	13-17
32691241-5	2020	The high nutrient concentrations, low flows, warm water and high solar radiation resulted in major algal blooms in the Kali and Ramganga, which greatly impacted the Ganga.	Water	50-55	SLAM family member 6	Homo sapiens	119-123
16551622-6	2006	TEA inhibition was lost upon a Tyr to Phe amino acid switch in the external water pore of AQP1/AQP2/AQP4, whereas the water permeability of AQP3 and AQP5, which lack a corresponding Tyr, was not blocked by TEA.	Water	118-123	aquaporin 3 (Gill blood group)	Homo sapiens	140-144
32766236-4	2020	In vitro results demonstrated that BET@COL collagen sponges strongly preserved water content up to 33.78 +- 0.78% at the 80th min at 37 C (only 0.44 +- 0.18% in control), and also exhibited high cell biocompatibility.	Water	79-84	delta/notch-like EGF repeat containing	Mus musculus	35-51
32914562-9	2020	Fos expression showed neuronal activation in the brain regions that are associated with the hypothalamus and/or are involved in maintaining water and electrolyte homeostasis in HTN- and PEG-treated rats.	Water	140-145	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
19127741-6	2006	With the increase of IgK(ow) (octanol-water partition coefficient) of the PAHs, both root concentration factors and leaf concentration factors increased exponentially, while translocation factors from roots to leaves decreased exponentially.	Water	38-43	immunoglobulin kappa locus	Homo sapiens	21-24
32829397-0	2021	Tap Water Avoidance Decreases Rates of Hospital-Onset Pulmonary Nontuberculous Mycobacteria.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
32766236-6	2020	The optimal BET@COL collagen sponges were able to maintain high water content (e.g., moist microenvironment), suppress oxidative stress, improve anti-inflammation, all of which impose synergetic healing effects to promote wound closure, granulation formation, re-epithelization, collagen deposition and angiogenesis.	Water	64-69	delta/notch-like EGF repeat containing	Mus musculus	12-28
16676986-2	2006	The reconstituted ferric myoglobin has a coordinating water molecule that deprotonates to hydroxide with a pK(a) value of 7.3 and exhibits 3-10-fold higher affinities for anionic ligands when compared with a counterpart myoglobin with the same substituents on the dipyrroethene moiety.	Water	54-59	myoglobin	Homo sapiens	25-34
32643526-2	2021	Here, we use free-water imaging, an advanced diffusion MRI technique, to identify white matter alterations in the brains of CHR subjects who subsequently develop psychosis (CHR-P) compared to those who do not (CHR-NP).	Water	18-23	chromate resistance; sulfate transport	Homo sapiens	124-127
32558567-2	2020	A tri(pyridinyl)pyridine viologen-based Kagome dual (kgd) topological coordination polymer, [Mn3Cl4(tpptb)2] Cl2 (H2O)2, (tpptb = N,N",N""-tri(3-carboxybenzyl)-2,4,6-tri(pyridinium-4-yl)pyridine; 1) has been solvothermally synthesized, which can selectively respond to soft X-ray Al-Kalpha (lambda = 8.357 A) irradiation but not to UV light and hard X-rays of lambda < 1.5418 A at room temperature.	Water	114-117	endogenous retrovirus group W member 5	Homo sapiens	109-112
32806671-2	2020	Water is one of the best choices, thus 100% aqueous electrolytes are proposed in this work, which are gelled with xanthan gum.	Water	0-5	OTU deubiquitinase with linear linkage specificity	Homo sapiens	122-125
16676986-2	2006	The reconstituted ferric myoglobin has a coordinating water molecule that deprotonates to hydroxide with a pK(a) value of 7.3 and exhibits 3-10-fold higher affinities for anionic ligands when compared with a counterpart myoglobin with the same substituents on the dipyrroethene moiety.	Water	54-59	myoglobin	Homo sapiens	220-229
33018267-0	2020	High-Resolution 3D Spin-Echo MRSI Using Interleaved Water Navigators, Sparse Sampling and Subspace-Based Processing.	Water	52-57	spindlin 1	Homo sapiens	19-23
16669626-4	2006	The resulting reaction pathways, found in the catalytically competent closed/closed conformation of the Switch-1/Switch-2 loops of myosin, are all associative with a pentavalent bipyramidal oxyphosphorane transition state but can vary in the activation mechanism of the attacking water molecule and in the way the hydrogens are transferred between the heavy atoms.	Water	280-285	myosin heavy chain 14	Homo sapiens	131-137
32145576-0	2020	Spatial variation of fipronil and its derivatives in tap water and ground water from China and the fate of them during drinking water treatment in Wuhan, central China.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
32361437-0	2020	Characterization of atmospheric trace gases and water soluble inorganic chemical ions of PM1 and PM2.5 at Indira Gandhi International Airport, New Delhi during 2017-18 winter.	Water	48-53	transmembrane protein 11	Homo sapiens	89-92
32361437-1	2020	Water soluble inorganic chemical ions of PM1 and PM2.5 and atmospheric trace gases were monitored simultaneously on hourly resolution at Indira Gandhi International Airport (IGIA), Delhi during 8 December 2017-10 February 2018.	Water	0-5	transmembrane protein 11	Homo sapiens	41-44
32361454-5	2020	Tap water 87Sr/86Sr from the Netherlands range from 0.70837 to 0.71278 (DeltaSrmax-min = 0.0044) and modern human enamel from 0.70847 to 0.70995 (DeltaSrmax-min = 0.0015).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
32145576-4	2020	The sum concentrations of FPs (SigmaFPs) in the tap water in China ranged from not detected (ND) to 5.07 (median: 0.03 ng/L), with FP found in 55.3% of the samples, and other targets <= 50.0%.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
16701014-14	2006	CONCLUSION: Vaccination with the synthetic TCR V(beta) 8.3 peptide could remarkably inhibit the development of EAU.	Water	111-114	T cell receptor alpha variable 12-3	Rattus norvegicus	43-46
32145576-6	2020	Similar SigmaFPs values were found for ground water and tap water.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
32145576-10	2020	Higher concentration of SigmaFPs in tap water was observed in July (median: 0.04 ng/L) compared to that in October (ND).	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
32778746-7	2020	Temperature favors the water sorption in the shales at high relative pressure, and the GAB isotherm model is found to be suitable for describe the water adsorption/desorption behavior.	Water	23-28	alpha-1-B glycoprotein	Homo sapiens	87-90
32778746-7	2020	Temperature favors the water sorption in the shales at high relative pressure, and the GAB isotherm model is found to be suitable for describe the water adsorption/desorption behavior.	Water	147-152	alpha-1-B glycoprotein	Homo sapiens	87-90
32770131-2	2020	Promoting the efficient use of tap water can contribute to sustainable drinking water management and progress towards Sustainable Development Goals.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
32770131-2	2020	Promoting the efficient use of tap water can contribute to sustainable drinking water management and progress towards Sustainable Development Goals.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	31-34
32325220-7	2020	However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine).	Water	308-313	dipeptidase 2	Homo sapiens	39-44
32770131-5	2020	The presence of residual chlorine in tap water, connected to municipal water supply, inactivates pathogenic microorganisms and prevents recontamination.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
16672644-11	2006	In addition, 2xAbeta1-15-immunized hAPP(FAD) animals showed improved acquisition of memory compared with vehicle controls in a reference-memory Morris water-maze behavior test that approximately correlated with anti-Abeta titers.	Water	151-156	amyloid beta (A4) precursor protein	Mus musculus	15-20
32770131-5	2020	The presence of residual chlorine in tap water, connected to municipal water supply, inactivates pathogenic microorganisms and prevents recontamination.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	37-40
32770131-6	2020	However, adding chlorine to tap water may affect the organoleptic properties of drinking water.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
32770131-6	2020	However, adding chlorine to tap water may affect the organoleptic properties of drinking water.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	28-31
32770131-7	2020	On the other hand, the use of point-of-use (POU) water dispensers, which provides an additional treatment step on tap water, is not energy-efficient.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	114-117
32770131-7	2020	On the other hand, the use of point-of-use (POU) water dispensers, which provides an additional treatment step on tap water, is not energy-efficient.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
32770131-8	2020	A randomized, double-blind water taste test was conducted in the Taipei metropolis to assess whether tap water from public drinking fountains and filtered water from POU water dispensers have similar organoleptic properties.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
32283107-4	2020	Water intake and drinking behavior are, in part, controlled by the actions of glucagon-like peptide-1 (GLP-1), a peptide which is well studied for its hypophagic effects.	Water	0-5	glucagon	Rattus norvegicus	78-101
32283107-4	2020	Water intake and drinking behavior are, in part, controlled by the actions of glucagon-like peptide-1 (GLP-1), a peptide which is well studied for its hypophagic effects.	Water	0-5	glucagon	Rattus norvegicus	103-108
32283107-11	2020	Water intake suppression when given Ex4 did not differ by diet or body weight regardless of injection site, however, adding support to the hypothesis that only central GLP-1 receptors are involved in water intake.	Water	200-205	glucagon	Rattus norvegicus	168-173
32375110-9	2020	Overall, this study could offer guidance for water treatment plants with respect to the selection of PAC to solve the odor problems caused by various compounds (e.g., DMDS or 2-MIB), and the modification of PAC, aiming at more efficient odor removal.	Water	45-50	MIB E3 ubiquitin protein ligase 1	Homo sapiens	177-180
32593289-1	2020	BACKGROUND: Most studies have reported that suicide mortality rates are negatively associated with lithium levels in tap water; however, a few studies showed either no association or a positive association.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
32770131-8	2020	A randomized, double-blind water taste test was conducted in the Taipei metropolis to assess whether tap water from public drinking fountains and filtered water from POU water dispensers have similar organoleptic properties.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
32770131-8	2020	A randomized, double-blind water taste test was conducted in the Taipei metropolis to assess whether tap water from public drinking fountains and filtered water from POU water dispensers have similar organoleptic properties.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
32593289-2	2020	Thus, the association between suicide mortality and lithium levels in tap water remains controversial.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
32593289-3	2020	To clarify the association, our study evaluated the association between lithium levels in tap water and suicide mortality rates in Miyazaki Prefecture of Japan, after adjusting for confounding factors.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
16352742-12	2006	OPC-31260 reversed upregulation and apical trafficking of AQP2 and pAQP2 in association with improved urinary diluting capacity and increased water excretion after oral water loading.	Water	169-174	aquaporin 2	Rattus norvegicus	58-62
32593289-6	2020	Weighted least-squares regression analysis, adjusted for the size of each municipality"s population, was used to investigate the association between lithium levels in tap water and suicide SMRs.	Water	171-176	nuclear RNA export factor 1	Homo sapiens	167-170
16574669-3	2006	Induction of kappaB-driven transcriptional activity by 2.5 mug ml(-1) F. tularensis LPS isolated by phenol-water and ether-water extraction, was observed in cells transfected with Toll-like receptor (TLR) 4 and MD-2, although CD14 was required for optimal induction.	Water	107-112	interferon regulatory factor 6	Homo sapiens	84-87
32605115-7	2020	The SF/PCL/CS scaffold showed a high interconnectivity between pores and porosity and water uptake abilities able to provide good conditions for cell infiltration and proliferation.	Water	86-91	polycystic kidney disease 2-like 1	Mus musculus	7-10
32605142-0	2020	Outcomes Assessment of Sustainable and Innovatively Simple Lifestyle Modification at the Workplace - Drinking Electrolyzed-Reduced Water (OASIS-ERW): A Randomized, Double-Blind, Placebo-Controlled Trial.	Water	131-136	cAMP responsive element binding protein 3 like 1	Homo sapiens	138-143
32648751-1	2020	In this study, the synthesis, characterization, and pressure response of a 1D californium mellitate (mellitate = 1,2,3,4,5,6-benzenehexacarboxylate) coordination polymer, Cf2(mell)(H2O)10 4H2O (Cf-1), are reported.	Water	181-184	ATPase H+ transporting accessory protein 1	Homo sapiens	171-174
32748885-8	2020	The study on the general features of the spin density topology is followed by the specific example of the water molecule in the 3B1 triplet state, using spin density distributions of increasing accuracy.	Water	106-111	spindlin 1	Homo sapiens	153-157
16597829-4	2006	Our data suggest that PEG-GCSF solubility was mediated by favorable solvation of water molecules around the PEG group.	Water	81-86	colony stimulating factor 3	Homo sapiens	26-30
32744543-1	2020	A water-soluble neutral homopolysaccharide (PLP-1) was obtained from the roots of Pueraria lobata by DEAE cellulose and Sephadex G-200 gel chromatography purification.	Water	2-7	proteolipid protein 1	Homo sapiens	44-49
32530018-3	2020	To ensure the drug release, the cathepsin B labile GFLG spacer was incorporated between the targeting peptide and the drug molecule (daunomycin), which significantly increased the hydrophobicity and thereby decreased the water solubility of the conjugates.	Water	221-226	cathepsin B	Homo sapiens	32-43
32641201-10	2020	Conclusions: Sequence type, virulence properties, and antibiotic resistance vary in Aeromonas isolates from clinical patients, tap water systems, and food.	Water	131-136	nuclear RNA export factor 1	Homo sapiens	127-130
32737440-8	2020	The enhanced hydrophobicity of MCS nanocomposites was related to the carbon content and the depletion of surface silanol groups, as confirmed by the water sorption measurement.	Water	149-154	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	31-34
16602793-3	2006	A three-component reaction involving ArP(O)(OH)2, 3,5-dimethylpyrazole(DMPZH), and Cu(CH3COO)2.H2O produces the tetranuclear Cu(II) compound [Cu4(mu3-OH)2{ArPO2(OH)}2(CH3CO2)2(DMPZH)4][CH3COO]2.CH2Cl2 (3).	Water	95-98	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	37-40
32793876-0	2020	An overlooked route of inhalation exposure to tap water constituents for children and adults: Aerosolized aqueous minerals from ultrasonic humidifiers.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
32655658-0	2020	Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats.	Water	29-34	brain-derived neurotrophic factor	Rattus norvegicus	92-96
32596197-0	2020	Physical Measures to Reduce Exposure to Tap Water-Associated Nontuberculous Mycobacteria.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
32596197-1	2020	Nontuberculous mycobacteria (NTM) that cause human disease can be isolated from household tap water.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
32793876-5	2020	When filled with tap water, water evaporated from emitted aerosols to form submicron particles that became essentially "dried tap water" with median size 146 nm and mean concentration of 211 mug-total elements/m3-air including 35 mug-calcium/m3-air in a room of 33.5 m3 and air exchange rate at ~0.8 hr-1.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
16455667-2	2006	Alternatively, as a result of its unusual conformational plasticity, alpha-synuclein may fold into an amphipathic helix upon contact with a lipid-water interface.	Water	146-151	synuclein alpha	Homo sapiens	69-84
32793876-5	2020	When filled with tap water, water evaporated from emitted aerosols to form submicron particles that became essentially "dried tap water" with median size 146 nm and mean concentration of 211 mug-total elements/m3-air including 35 mug-calcium/m3-air in a room of 33.5 m3 and air exchange rate at ~0.8 hr-1.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	17-20
32793876-5	2020	When filled with tap water, water evaporated from emitted aerosols to form submicron particles that became essentially "dried tap water" with median size 146 nm and mean concentration of 211 mug-total elements/m3-air including 35 mug-calcium/m3-air in a room of 33.5 m3 and air exchange rate at ~0.8 hr-1.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	126-129
32793876-5	2020	When filled with tap water, water evaporated from emitted aerosols to form submicron particles that became essentially "dried tap water" with median size 146 nm and mean concentration of 211 mug-total elements/m3-air including 35 mug-calcium/m3-air in a room of 33.5 m3 and air exchange rate at ~0.8 hr-1.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	17-20
32793876-5	2020	When filled with tap water, water evaporated from emitted aerosols to form submicron particles that became essentially "dried tap water" with median size 146 nm and mean concentration of 211 mug-total elements/m3-air including 35 mug-calcium/m3-air in a room of 33.5 m3 and air exchange rate at ~0.8 hr-1.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	126-129
32718994-4	2020	Its myosin tails are arranged in curved molecular crystalline layers identical to flight muscles of the giant water bug Lethocerus indicus Four non-myosin densities are observed, three of which correspond to ones found in Lethocerus; one new density, possibly stretchin-mlck, is found on the backbone outer surface.	Water	110-115	zipper	Drosophila melanogaster	4-10
32793547-1	2020	Alumina porous monoliths were successfully fabricated using a simple and reproducible synthesis dispersing gamma alumina phase from commercial boehmite (GAB) in water containing water-soluble bio-based substances (BBSs) obtained from composted biowaste.	Water	161-166	alpha-1-B glycoprotein	Homo sapiens	153-156
32749303-8	2020	In addition, the relative importance findings suggest that the air-water temperature difference, temporal hour weight, and time of year, as measured through seasonality, have strong associations with Cn2 and could be included to improve model prediction accuracy.	Water	67-72	carnosine dipeptidase 2	Homo sapiens	200-203
32639724-6	2020	1H NMR (Lu3+) and spectrophotometric titrations of the isolated [TbL1]- complex by EuCl3 salts demonstrated the formation of high-order (hetero)polymetallic species in aqueous solution (H2O, pH = 7).	Water	186-189	transducin beta like 1 Y-linked	Homo sapiens	65-69
32683585-0	2020	Assessment of water quality compartments in Kor River, IRAN.	Water	14-19	opioid receptor kappa 1	Homo sapiens	44-47
32774757-7	2020	In addition, higher expression of miR-135b and miR-29c was observed after the consumption of alkaline water for 5 months.	Water	102-107	microRNA 135b	Homo sapiens	34-42
32555827-1	2020	We experimentally study the stochastic transport of a self-propelled camphor boat, driven by Marangoni forces, through a crowd of passive paper discs floating on water.	Water	162-167	ataxin 1 like	Homo sapiens	77-81
32143160-2	2020	In this study, carboxymethyl beta-cyclodextrin (CM-beta-CD), as an alternative to gold nanoparticle, was used to modified titanium dioxide (CM-beta-CD-P25) to accelerate photoelectron transmission and enhance the organic contaminants removal from water.	Water	247-252	tubulin polymerization promoting protein	Homo sapiens	151-154
32358915-0	2020	Targeting the water network in cyclin G associated kinase (GAK) with 4-anilino-quin(az)oline inhibitors.	Water	14-19	cyclin G associated kinase	Homo sapiens	31-57
32358915-0	2020	Targeting the water network in cyclin G associated kinase (GAK) with 4-anilino-quin(az)oline inhibitors.	Water	14-19	cyclin G associated kinase	Homo sapiens	59-62
32358915-4	2020	The GAK cellular target engagement assays, ATP binding site modelling and extensive water mapping provide a clear route to access potent inhibitors for GAK and beyond.	Water	84-89	cyclin G associated kinase	Homo sapiens	4-7
32358915-4	2020	The GAK cellular target engagement assays, ATP binding site modelling and extensive water mapping provide a clear route to access potent inhibitors for GAK and beyond.	Water	84-89	cyclin G associated kinase	Homo sapiens	152-155
32035161-9	2020	Peroxidase cycle results demonstrate that tyrosine phosphorylation blocks MPO Compound I formation by preventing catalysis on H2O2 in the active site of MPO.	Water	126-130	myeloperoxidase	Mus musculus	74-77
32035161-9	2020	Peroxidase cycle results demonstrate that tyrosine phosphorylation blocks MPO Compound I formation by preventing catalysis on H2O2 in the active site of MPO.	Water	126-130	myeloperoxidase	Mus musculus	153-156
32446537-1	2020	Monte Carlo simulations of gamma/fast electron-radiolysis of water show that the in situ formation of H3O+ temporarily renders each "native" isolated spur/track region very acidic.	Water	61-66	H3 clustered histone 15	Homo sapiens	102-105
32728594-4	2020	Our results show that population under water stress is expected to increase by 50% under a low population growth and emissions scenario (SSP1-RCP2.6) and double under a high population growth and emission scenario (SSP3-RCP6.0), compared to the year 2010.	Water	39-44	SUMO specific peptidase 3	Homo sapiens	215-219
32193595-6	2020	BTR was assessed using a water-perfused suit, with participants regulating the water-perfused suit temperature (Twps) within a range, considered as thermally comfortable.	Water	25-30	G protein-coupled receptor 148	Homo sapiens	0-3
32464345-4	2020	We further show that LGR5 labels SOX17+/CD31+/CD34+/CD133+/AQP1+/CD146+ endothelial progenitor cells within the descending vasa recta or straight arterioles of the kidney, which are specialized capillaries that maintain medullary osmotic gradients necessary for water reabsorption and the production of concentrated urine.	Water	262-267	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	21-25
32605327-1	2020	The water-soluble polysaccharide EP2, from Enteromorpha prolifera, belongs to the group of polysaccharides known as glucuronoxylorhamnan, which mainly contains glucuronic acid (GlcA), xylose (Xyl), and rhamnose (Rha).	Water	4-9	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	33-36
32610976-0	2020	Quasielastic neutron scattering studies on couplings of protein and water dynamics in hydrated elastin.	Water	68-73	elastin	Homo sapiens	95-102
32610976-1	2020	Performing quasielastic neutron scattering measurements and analyzing both elastic and quasielasic contributions, we study protein and water dynamics of hydrated elastin.	Water	135-140	elastin	Homo sapiens	162-169
32610976-6	2020	This Arrhenius behavior of water diffusion is consistent with previous results for water reorientation, but at variance with a fragile-to-strong crossover at ~225 K. The hydration-related elastin backbone motion is localized and can be attributed to the cage rattling motion.	Water	27-32	elastin	Homo sapiens	188-195
32610976-6	2020	This Arrhenius behavior of water diffusion is consistent with previous results for water reorientation, but at variance with a fragile-to-strong crossover at ~225 K. The hydration-related elastin backbone motion is localized and can be attributed to the cage rattling motion.	Water	83-88	elastin	Homo sapiens	188-195
32610976-7	2020	We speculate that its onset at ~195 K is related to a secondary glass transition, which occurs when a beta relaxation of the protein has a correlation time of taubeta ~ 100 s. Moreover, we show that its temperature-dependent amplitude has a crossover at the regular glass transition Tg = 320 K of hydrated elastin, where the alpha relaxation of the protein obeys taualpha ~ 100 s. By contrast, we do not observe a protein dynamical transition when water dynamics enters the experimental time window at ~240 K.	Water	448-453	elastin	Homo sapiens	306-313
32203798-7	2020	More importantly, the sensor has a high recovery rate when it is used to detect nitrite in tap water, mineral water, and sausage, indicating the feasibility of using this sensor in practical applications.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
32637810-6	2020	Interestingly, this led to CNF showing similar performance to C30B, decreasing water diffusivity (21 vs 27%) on isothermally crystallized materials despite its less favorable geometry.	Water	79-84	NPHS1 adhesion molecule, nephrin	Homo sapiens	27-30
32637810-7	2020	Additionally, the incorporation of 1 wt % CNF and C30B decreased water vapor transmission rate (WVTR) by 24% under an amorphous state but by 44% in a crystallized state, which makes hybrid CNF/C30B composites a promising food packaging material.	Water	65-70	NPHS1 adhesion molecule, nephrin	Homo sapiens	42-45
32637810-7	2020	Additionally, the incorporation of 1 wt % CNF and C30B decreased water vapor transmission rate (WVTR) by 24% under an amorphous state but by 44% in a crystallized state, which makes hybrid CNF/C30B composites a promising food packaging material.	Water	65-70	NPHS1 adhesion molecule, nephrin	Homo sapiens	189-192
32538598-8	2020	Wound irrigation with normal saline or tap water is recommended after foreign body removal.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
32097855-0	2020	Thiol-functionalized magnetic covalent organic frameworks by a cutting strategy for efficient removal of Hg2+ from water.	Water	115-120	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	105-108
32097855-4	2020	After the cutting process, the crystallinity, porosity, superparamagnetism of pristine M-COF are well maintained, and the resultant M-COF-SH turned out to be an effective and selective platform for Hg2+ capture from water.	Water	216-221	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	198-201
32251636-3	2020	Previous studies have shown that aquaporin-4 (AQP4) modulates brain water transport and endothelin-1 (ET-1) induces cerebral edema.	Water	68-73	aquaporin 4	Mus musculus	33-44
32251636-3	2020	Previous studies have shown that aquaporin-4 (AQP4) modulates brain water transport and endothelin-1 (ET-1) induces cerebral edema.	Water	68-73	aquaporin 4	Mus musculus	46-50
32549394-2	2020	This work presents the catalytic reduction of 4-nitrophenol (4-Nip) to 4-aminophenol (4-Amp) in the presence of Pd nanoparticles and sodium borohydride as reductants in water.	Water	169-174	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	63-66
32532282-4	2020	METHODS: The hypertensive rat model was used to study the role of CX3CR1-microglia in NTS inflammation following hypertension induction by oral administration of 10% fructose water.	Water	175-180	C-X3-C motif chemokine receptor 1	Rattus norvegicus	66-72
32587522-1	2020	Background: Aquaporin 5 (AQP5) is a water channel-forming protein that plays a key role in saliva secretion.	Water	36-41	aquaporin 5	Rattus norvegicus	12-23
32587522-1	2020	Background: Aquaporin 5 (AQP5) is a water channel-forming protein that plays a key role in saliva secretion.	Water	36-41	aquaporin 5	Rattus norvegicus	25-29
32285591-8	2020	Furthermore, using the CIRP-/- mice, we found that CIRP-/- mice had less brain damages showing in less FJB+ cells, reduced brain water content (BWC) and lower neurological deficit scores (NDS) compared to that in WT mice after ICH.	Water	129-134	cold inducible RNA binding protein	Mus musculus	51-55
32453603-0	2020	Isotope and chemical assessment of natural water in the Jaffna Peninsula in northern Sri Lanka for groundwater development aspects.	Water	43-48	sorcin	Homo sapiens	85-88
32453603-1	2020	The demand for fresh groundwater in the Jaffna peninsula in northern Sri Lanka, has been increasing as the only water source for domestic and agricultural needs.	Water	27-32	sorcin	Homo sapiens	69-72
32014500-6	2020	The elevated levels of H2O2 (a biomarker of oxidative stress) and the free radicals (NO  and O2 -) reduced the concentration of dominant pathogens and regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1).	Water	23-27	acetyl-CoA carboxylase alpha	Homo sapiens	358-382
32014500-6	2020	The elevated levels of H2O2 (a biomarker of oxidative stress) and the free radicals (NO  and O2 -) reduced the concentration of dominant pathogens and regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1).	Water	23-27	acetyl-CoA carboxylase alpha	Homo sapiens	384-388
33880435-0	2020	Supramolecular assembly of Toll-like receptor 7/8 agonist into multimeric water-soluble constructs enables superior immune stimulation in vitro and in vivo.	Water	74-79	toll-like receptor 7	Mus musculus	27-49
33880435-3	2020	Here, we report a multimeric TLR 7/8 construct of nano-scale size, which results from a spontaneous self-assembly of RSQD with a water-soluble clinical-stage polymer - poly[di(carboxylatophenoxy)phosphazene] (PCPP).	Water	129-134	toll-like receptor 7	Mus musculus	29-36
32499808-7	2020	Throughout the experiment, values of leaf water potential ranged from -0.4 (CTRL) to -1.1 MPa (IRR 30%) and it linearly influenced the leaf angle when measured manually (R 2 = 0.86) and with 3D image (R 2 = 0.73).	Water	42-47	insulin receptor related receptor	Homo sapiens	95-98
32478245-0	2020	Potent HCV NS3 Protease Inhibition by a Water-Soluble Phyllanthin Congener.	Water	40-45	KRAS proto-oncogene, GTPase	Homo sapiens	11-14
32293901-5	2020	We find that the carboxyl group shows two distinct near-planar conformers (syn and anti) when dissolved in water at room temperature.	Water	107-112	synemin	Homo sapiens	75-78
32293901-7	2020	Molecular dynamics simulations show that the anti-conformer interacts more strongly with water molecules than the syn-conformer, explaining why this conformer is significantly present in aqueous solution.	Water	89-94	synemin	Homo sapiens	114-117
32369477-0	2020	Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep.	Water	28-33	aquaporin 4	Homo sapiens	42-46
32369477-1	2020	Cerebrospinal fluid (CSF) flow through the brain parenchyma is facilitated by the astrocytic water channel aquaporin 4 (AQP4).	Water	93-98	aquaporin 4	Homo sapiens	120-124
32369477-3	2020	The human AQP4 gene harbors several single nucleotide polymorphisms (SNPs) associated with AQP4 expression, brain-water homeostasis, and neurodegenerative diseases.	Water	114-119	aquaporin 4	Homo sapiens	10-14
32105506-2	2020	We show here that the irradiation of astrophysical ice analogues containing H2O, CH3OH, CO, and NH3 yields quantities of hexamethylenetetramine-methanol (hereafter HMT-methanol; C7N4H14O) that are easily detectible in the resulting organic residues.	Water	76-79	histamine N-methyltransferase	Homo sapiens	164-167
31912910-6	2020	The results showed that GLA pretreatment improved the viability of H2 O2 -induced HCASMCs.	Water	67-72	galactosidase alpha	Homo sapiens	24-27
31912910-7	2020	The increased reactive oxygen species production and decreased superoxide dismutase and glutathione peroxidase activities in H2 O2 -induced HCASMCs were reversed by GLA pretreatment.	Water	125-130	galactosidase alpha	Homo sapiens	165-168
31912910-8	2020	In addition, GLA treatment suppressed the H2 O2 -induced expression of inducible nitric oxide synthase, NADPH oxidase (NOX) 2, and NOX4 in HCASMCs.	Water	42-47	galactosidase alpha	Homo sapiens	13-16
31912910-8	2020	In addition, GLA treatment suppressed the H2 O2 -induced expression of inducible nitric oxide synthase, NADPH oxidase (NOX) 2, and NOX4 in HCASMCs.	Water	42-47	cytochrome b-245 beta chain	Homo sapiens	104-125
32052323-3	2020	Water-soluble ionic contents were also more distributed in PM1.1 with the great contents of secondary particles (NO3-, SO42-, and NH4+).	Water	0-5	transmembrane protein 11	Homo sapiens	59-62
32202681-4	2020	Water transport is activated and, IP3 R, TRPA1, TRPV4, and Aquaporin-4 are all involved in shaping the dynamics of infrared pulse-evoked intracellular calcium signal.	Water	0-5	aquaporin 4	Homo sapiens	59-70
32146649-3	2020	Addition of Hg2+ ion to the sensor solution in 2:8 EtOH/H2O induced a hypsochromic shift of the UV-Vis absorption band from 360 nm to 340 nm accompanying distinct enhancement in the absorption intensity while addition of other metal ions failed to bring about substantial change in the absorption spectra.	Water	56-59	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	12-15
32349399-3	2020	Sequential photolysis-microbial biodegradation processes were utilized here to treat BDE-209 in clay- or soil-water slurries.	Water	110-115	homeobox D13	Homo sapiens	85-88
32349399-5	2020	In the clay-water slurries the first order rate constants for the UV photolysis and biodegradation of BDE-209 were 0.017 1/day and 0.026 1/day, respectively.	Water	12-17	homeobox D13	Homo sapiens	102-105
32300188-6	2020	By using three road-specific parameters estimated by our proposed model, namely, the free-flow speed, jam density, and capacity flow, a link transmission model is developed to analyse the dynamic impact of the water film depth.	Water	210-215	F11 receptor	Homo sapiens	102-105
32100538-2	2020	A commercially available activated carbon felt has been found to effectively capture lead from tap water, and partnered with X-Ray fluorescence (XRF) spectrometry, it provides quantitative measurement of aqueous lead in drinking water.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
32100538-3	2020	Specifically, for a 2-liter volume of tap water, the linear range of detection was found to be from 1 - 150 ppb, encompassing the current EPA limit for lead in drinking water (15 ppb).	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
33488173-5	2020	Calculated (B3LYP/6-311++G(d,p) level) and experimental UV-Vis absorption spectra of the compounds were found to be in good agreement in water.	Water	137-142	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	14-17
32218435-6	2020	Behaviorally, Kv4.2TA mice displayed normal initial learning but improved reversal learning in both Morris water maze and lever press paradigms.	Water	107-112	potassium voltage-gated channel, Shal-related family, member 2	Mus musculus	14-19
31926226-5	2020	We found that in high-fat diet model, native carrageenan in drinking water increased the disease activity index (DAI), myeloperoxidase (MPO) activity and the mRNA expression of TLR4 in colon, whereas carrageenan-supplemented diet has no visible effects.	Water	69-74	myeloperoxidase	Mus musculus	119-134
31926226-5	2020	We found that in high-fat diet model, native carrageenan in drinking water increased the disease activity index (DAI), myeloperoxidase (MPO) activity and the mRNA expression of TLR4 in colon, whereas carrageenan-supplemented diet has no visible effects.	Water	69-74	myeloperoxidase	Mus musculus	136-139
31896003-2	2020	In this study, we for the first time revealed the role of the air-water interface in enhancing the removal of long-chain perfluoroalkyl carboxylic (PFCAs; CnF2n+1COOH, n >= 7) and perfluoroalkane sulfonic (PFSAs; CnF2n+1SO3H, n >= 6) acids, collectively termed as perfluoroalkyl acids (PFAAs), through combined aeration and adsorption on two kinds of activated carbon (AC).	Water	66-71	NPHS1 adhesion molecule, nephrin	Homo sapiens	155-158
31896003-2	2020	In this study, we for the first time revealed the role of the air-water interface in enhancing the removal of long-chain perfluoroalkyl carboxylic (PFCAs; CnF2n+1COOH, n >= 7) and perfluoroalkane sulfonic (PFSAs; CnF2n+1SO3H, n >= 6) acids, collectively termed as perfluoroalkyl acids (PFAAs), through combined aeration and adsorption on two kinds of activated carbon (AC).	Water	66-71	NPHS1 adhesion molecule, nephrin	Homo sapiens	213-216
33455369-3	2020	In this study, a new type of water-stable silk sponge (ASF-PEG-S) was obtained by inducing nanoparticle (50-300 nm in diameter) formation in SF solution by autoclaving followed by freeze-drying and rinsing the dry sponges with low-molecular weight (400 Da) polyethylene glycol (PEG400) to induce SF beta-sheet structure formation and thus stability in water.	Water	29-34	arylsulfatase F	Homo sapiens	55-58
33455369-3	2020	In this study, a new type of water-stable silk sponge (ASF-PEG-S) was obtained by inducing nanoparticle (50-300 nm in diameter) formation in SF solution by autoclaving followed by freeze-drying and rinsing the dry sponges with low-molecular weight (400 Da) polyethylene glycol (PEG400) to induce SF beta-sheet structure formation and thus stability in water.	Water	352-357	arylsulfatase F	Homo sapiens	55-58
33455369-6	2020	In addition, ASF-PEG-S absorbed water nearly 40 times more than its dry weight, while the methanol-annealed sponges absorbed half this amount.	Water	32-37	arylsulfatase F	Homo sapiens	13-16
32182932-6	2020	The TBP-peeling cellulose strand has a uniquely favorable and potentially net negative pairwise energy contribution in the TBPCl-water solution, which may partially explain why it is capable of dissolving cellulose at moderate temperatures and high water concentrations.	Water	129-134	TATA-box binding protein	Homo sapiens	4-7
32182932-6	2020	The TBP-peeling cellulose strand has a uniquely favorable and potentially net negative pairwise energy contribution in the TBPCl-water solution, which may partially explain why it is capable of dissolving cellulose at moderate temperatures and high water concentrations.	Water	249-254	TATA-box binding protein	Homo sapiens	4-7
32138192-6	2020	Furthermore, ARF4-as displayed higher tolerance to salt and osmotic stress through reduced stomatal conductance coupled with increased leaf relative water content and Abscisic acid (ABA) content under normal and stressful conditions.	Water	149-154	auxin response factor 4	Solanum lycopersicum	13-17
32053354-7	2020	The detection site of nitrobenzene in framework 1 was confirmed by single-crystal X-ray diffraction, [Zn3(TTPA)2(DHTP)3] (H2O)(DMF)(2NB) or 1   NB.	Water	122-125	alpha tocopherol transfer protein	Homo sapiens	106-110
31669991-8	2020	The low distribution ability of the model compounds from water to hTTR may be the reason why they exhibited the binding potency observed with hTTR.	Water	57-62	transthyretin	Homo sapiens	66-70
31669991-8	2020	The low distribution ability of the model compounds from water to hTTR may be the reason why they exhibited the binding potency observed with hTTR.	Water	57-62	transthyretin	Homo sapiens	142-146
32596197-5	2020	First, suspensions of tap water-adapted Mycobacterium smegmatis were passed through either a point-of-use, disposable, 7-day or 14-day Pall-Aquasafe filter.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
32596197-8	2020	Third, suspensions of tap water-adapted M. abscessus, M. avium, and M. chimaera ("MycoCocktail") were passed through the "LifeStraw GO" hollow-fiber, two-stage membrane filtration system.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
32145630-3	2020	According to aquifer lithologic and tectonic differences, the hydrochemical compositions of hot springs displayed an apparent regional-specific pattern with distinct distributions of major and trace elements (e.g., Ca2+, Mg2+, F-/B) and were primarily formed by water-rock interaction across the three hydrothermal fields.	Water	262-267	alcohol dehydrogenase iron containing 1	Homo sapiens	92-95
32364556-2	2020	Crystals of MOF 2, in turn, undergo a cascade conversion when immersed in DEF, yielding [Cd3(BTB)2(BPEE)1.8(DEF)0.9(H2O)0.8] xSol (3a) over 100 seconds and [Cd3(BTB)2(BPEE)2(DEF)2] xSol (4) after one hour, before finally shuttling back to MOF 1 after six hours.	Water	116-119	UTP25 small subunit processome component	Homo sapiens	74-77
32100408-8	2020	Washing with a water-acetonitrile gradient during SPE improved the LLOD of OT in spiked serum to 2.5 pg/mL while adding a subsequent online-concentration step improved the LLOD in spiked urine to 1-5 pg/mL and allowed us to detect OT in urine from lactating women.	Water	15-20	oxytocin/neurophysin I prepropeptide	Homo sapiens	75-77
32112796-8	2020	Intestinal tissues and derived enteroids from MYO5B(P663L) piglets had reduced apical levels and diffuse sub-apical levels of NHE3 and SGLT1, which regulate transport of sodium, glucose, and water, compared with tissues from control piglets.	Water	191-196	solute carrier family 9 member A3	Sus scrofa	126-130
32160330-5	2020	RESULTS: In monoculture 1,25(OH)2 D3 suppressed CD4+ T-lymphocyte proliferation, increased the percentage of CD4+ FoxP3+ CD25+ FoxP3+ Tregs and enhanced IL-10 and TGF-beta1 production.	Water	28-33	interleukin 10	Homo sapiens	153-158
32627468-12	2020	Sijunzi Decoction water extract could reduce the Abeta_(25-35) oligomer-induced cytotoxicity of HBMEC, decrease the expression of RAGE mRNA and RAGE protein, and increase the expression of GLUT1 mRNA, LRP1 mRNA and LRP1 protein.	Water	18-23	advanced glycosylation end-product specific receptor	Homo sapiens	130-134
32627468-12	2020	Sijunzi Decoction water extract could reduce the Abeta_(25-35) oligomer-induced cytotoxicity of HBMEC, decrease the expression of RAGE mRNA and RAGE protein, and increase the expression of GLUT1 mRNA, LRP1 mRNA and LRP1 protein.	Water	18-23	advanced glycosylation end-product specific receptor	Homo sapiens	144-148
32627468-12	2020	Sijunzi Decoction water extract could reduce the Abeta_(25-35) oligomer-induced cytotoxicity of HBMEC, decrease the expression of RAGE mRNA and RAGE protein, and increase the expression of GLUT1 mRNA, LRP1 mRNA and LRP1 protein.	Water	18-23	solute carrier family 2 member 1	Homo sapiens	189-194
32523952-4	2020	The expression of the aquaporin-4 (AQP4) water channel relates to brain swelling, however, its regulation is poorly understood.	Water	41-46	aquaporin 4	Mus musculus	22-33
32523952-4	2020	The expression of the aquaporin-4 (AQP4) water channel relates to brain swelling, however, its regulation is poorly understood.	Water	41-46	aquaporin 4	Mus musculus	35-39
32548399-2	2020	A H2O-HNO3-UO2(NO3)2-TBP (tri-n-butyl phosphate)-diluent system is commonly used for uranium separation and purification in liquid-liquid extraction.	Water	2-5	TATA-box binding protein	Homo sapiens	21-24
32548399-8	2020	The predicted results show that water and nitric acid were extracted as di-solvates HNO3 (TBP)2 H2O and (TBP)2 2H2O at low nitric acid concentrations, with the formation of mono-solvates HNO3 TBP and HNO3 TBP H2O as the acid concentration increased.	Water	32-37	TATA-box binding protein	Homo sapiens	90-93
32548399-8	2020	The predicted results show that water and nitric acid were extracted as di-solvates HNO3 (TBP)2 H2O and (TBP)2 2H2O at low nitric acid concentrations, with the formation of mono-solvates HNO3 TBP and HNO3 TBP H2O as the acid concentration increased.	Water	32-37	TATA-box binding protein	Homo sapiens	105-108
32548399-8	2020	The predicted results show that water and nitric acid were extracted as di-solvates HNO3 (TBP)2 H2O and (TBP)2 2H2O at low nitric acid concentrations, with the formation of mono-solvates HNO3 TBP and HNO3 TBP H2O as the acid concentration increased.	Water	32-37	TATA-box binding protein	Homo sapiens	105-108
32548399-8	2020	The predicted results show that water and nitric acid were extracted as di-solvates HNO3 (TBP)2 H2O and (TBP)2 2H2O at low nitric acid concentrations, with the formation of mono-solvates HNO3 TBP and HNO3 TBP H2O as the acid concentration increased.	Water	32-37	TATA-box binding protein	Homo sapiens	105-108
32548399-8	2020	The predicted results show that water and nitric acid were extracted as di-solvates HNO3 (TBP)2 H2O and (TBP)2 2H2O at low nitric acid concentrations, with the formation of mono-solvates HNO3 TBP and HNO3 TBP H2O as the acid concentration increased.	Water	96-99	TATA-box binding protein	Homo sapiens	90-93
32548399-8	2020	The predicted results show that water and nitric acid were extracted as di-solvates HNO3 (TBP)2 H2O and (TBP)2 2H2O at low nitric acid concentrations, with the formation of mono-solvates HNO3 TBP and HNO3 TBP H2O as the acid concentration increased.	Water	112-115	TATA-box binding protein	Homo sapiens	105-108
32548399-8	2020	The predicted results show that water and nitric acid were extracted as di-solvates HNO3 (TBP)2 H2O and (TBP)2 2H2O at low nitric acid concentrations, with the formation of mono-solvates HNO3 TBP and HNO3 TBP H2O as the acid concentration increased.	Water	112-115	TATA-box binding protein	Homo sapiens	105-108
32548399-8	2020	The predicted results show that water and nitric acid were extracted as di-solvates HNO3 (TBP)2 H2O and (TBP)2 2H2O at low nitric acid concentrations, with the formation of mono-solvates HNO3 TBP and HNO3 TBP H2O as the acid concentration increased.	Water	112-115	TATA-box binding protein	Homo sapiens	105-108
32548399-9	2020	Uranyl nitrate was shown to be rejected from the organic phase as the formation of HNO3 TBP and HNO3 TBP H2O in acid was extracted at high acid concentrations.	Water	105-108	TATA-box binding protein	Homo sapiens	101-104
32443821-2	2020	Crop-mulberry systems are important agroforestry systems for controlling soil, water, and nutrient losses.	Water	79-84	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	0-4
32462076-7	2020	Results: Inhibition of intestinal NHE3 by SAR increased fecal sodium excretion, resulted in marked changes in feces electrolyte concentrations and water content, reduced blood pressure and preserved atrial emptying function (active total percent emptying: SHR-ob SAR: 0.47 +- 0.05% vs. SHR-ob PLAC: 0.38 +- 0.007, p < 0.0001).	Water	147-152	solute carrier family 9 member A3	Homo sapiens	34-38
32424171-5	2020	We found that cyclin D2-/- mice had robust and sustained loss of long-term memory in two separate behavioral tasks, Morris water maze (MWM) and touchscreen intermediate pattern separation.	Water	123-128	cyclin D2	Mus musculus	14-23
32265297-9	2020	An analysis of water access channels revealed only a few diffusion trajectories for the catalytically active form of OTUB1, whereas in OTUB2 the catalytic site was solvent accessible, and a larger number of water molecules reached and left the binding pocket.	Water	207-212	OTU deubiquitinase, ubiquitin aldehyde binding 2	Homo sapiens	135-140
32413299-3	2020	The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water flux across the blood-brain and blood-spinal cord barriers.	Water	4-9	aquaporin 4	Homo sapiens	26-37
32413299-3	2020	The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water flux across the blood-brain and blood-spinal cord barriers.	Water	4-9	aquaporin 4	Homo sapiens	39-43
32380695-7	2020	EAU induction increased the levels of cytokines (interleukin (IL)-1alpha, IL-1beta, IL-4, IL-6, IL-12, IL-17, and tumor necrosis factor (TNF)-alpha) and chemokines (monocyte chemoattractant protein (MCP)-1) in the retinas of wild-type mice but not in those of Ncf1-/- mice.	Water	0-3	interleukin 17A	Mus musculus	103-108
32380695-7	2020	EAU induction increased the levels of cytokines (interleukin (IL)-1alpha, IL-1beta, IL-4, IL-6, IL-12, IL-17, and tumor necrosis factor (TNF)-alpha) and chemokines (monocyte chemoattractant protein (MCP)-1) in the retinas of wild-type mice but not in those of Ncf1-/- mice.	Water	0-3	chemokine (C-C motif) ligand 2	Mus musculus	165-205
31912910-9	2020	Moreover, treatment with GLA reduced the production of several inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, and IL-1beta in H2 O2 -induced HCASMCs.	Water	162-167	galactosidase alpha	Homo sapiens	25-28
31912910-11	2020	These findings suggested that GLA protected against H2 O2 -induced oxidative stress and inflammation via inhibition of p38 phosphorylation and NF-kappaB activation in HCASMCs.	Water	52-57	galactosidase alpha	Homo sapiens	30-33
32040235-0	2020	Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway.	Water	14-19	Kelch-like ECH-associated protein 1	Rattus norvegicus	77-82
32492011-2	2020	In this report, we studied the structure of Ngb of the cold-water sponge Halisarca dujardinii.	Water	60-65	neuroglobin	Homo sapiens	44-47
32377040-4	2020	The shoots of I 167 seedlings also showed a parallel increase in alcohol dehydrogenase and pyruvate decarboxylase activities under water logging stress.	Water	131-136	uncharacterized protein LOC100285036	Zea mays	65-86
32353977-3	2020	The water vapour sorption capacity of PILs was evaluated as a function of relative humidity and the influence of the alkyl chain length on the phase behaviour in the PIL-water system was discussed.	Water	4-9	serpin family A member 2 (gene/pseudogene)	Homo sapiens	38-41
32353977-3	2020	The water vapour sorption capacity of PILs was evaluated as a function of relative humidity and the influence of the alkyl chain length on the phase behaviour in the PIL-water system was discussed.	Water	170-175	serpin family A member 2 (gene/pseudogene)	Homo sapiens	38-41
32139512-6	2020	By chemically synthesizing a water-soluble ligand analog, inositol-monophosphate dimannose (IPM2), we confirmed the direct interaction of DCAR with the polar moiety of AcPIMs by biolayer interferometry and co-crystallization approaches.	Water	29-34	C-type lectin domain family 4, member b1	Mus musculus	138-142
32223124-3	2020	Here, we show that a dHDL-relevant complex can also be prepared by gently mixing 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and apoA-I or its mutants in ethanol/H2O solutions containing urea in the order of a few molar, and then incubating the mixture at the gel-liquid crystalline phase transition temperature in test tubes.	Water	169-172	Hdl	Drosophila melanogaster	21-25
32195564-5	2020	The hybrid cell shows an extremely high stability of 10000 cycles with a record little capacity loss of 0.0027% per cycle, since Zn-reinforced SA-PAM SE successfully inhibits free water molecules from occupying low-spinning metallic sites (Fe-C) in Na0.5FeFe(CN)6.	Water	180-185	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	146-149
32208599-7	2020	Anchoring fluorinated groups (-CF2- and -CF3) with very low dispersive and non-dispersive surface energy leads to superoleophobicity and superhydrophobicity, resulting in repelling both water and diiodomethane.	Water	186-191	ATPase H+ transporting accessory protein 1	Homo sapiens	31-34
32293546-1	2020	Most cases of neuromyelitis optica spectrum disorders (NMOSD) harbor pathogenic autoantibodies against the water channel aquaporin 4 (AQP4).	Water	107-112	aquaporin 4	Homo sapiens	134-138
32295148-3	2020	Numerous established studies show that exposure to Cr6+ via drinking water leads to elevated chromium levels in tissues, which may result in various forms of cancer.	Water	69-74	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	51-54
32295148-5	2020	Synthesis and characterization of such composite nanomaterials, along with an initial experimental evaluation of Cr6+ removal from water-based solution, are presented.	Water	131-136	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	113-116
32270289-0	2020	Development of a sensitive and accurate method for the simultaneous determination of selected insecticides and herbicide in tap water and wastewater samples using vortex-assisted switchable solvent-based liquid-phase microextraction prior to determination by gas chromatography-mass spectrometry.	Water	128-133	nuclear RNA export factor 1	Homo sapiens	124-127
32270289-1	2020	In this study, a switchable solvent-based liquid-phase microextraction method was developed to preconcentrate selected pesticides from tap water and wastewater matrices for determination by gas chromatography-mass spectrometry.	Water	139-144	nuclear RNA export factor 1	Homo sapiens	135-138
32270289-7	2020	Tap water, municipal wastewater and medical wastewater were spiked at three different concentrations and analyzed under the method"s optimum conditions.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
32227049-7	2020	We found that a water molecule dissociates on AlP monolayer with a dissociative energy barrier of 0.42 eV, but it can be stably adsorbed on the BP, GaP and InP monolayers without the breakage of O-H bonds.	Water	16-21	ATHS	Homo sapiens	46-49
31784877-0	2020	Cantilever Nanobiosensor Functionalized with Tyrosinase for Detection of Estrone and beta-estradiol in Water.	Water	103-108	tyrosinase	Homo sapiens	45-55
32359324-0	2020	Ship source level estimation and uncertainty quantification in shallow water via Bayesian marginalization.	Water	71-76	inositol polyphosphate-5-phosphatase D	Homo sapiens	0-4
32359324-1	2020	This paper applies a non-linear Bayesian marginalization approach to ship spectral source level estimation in shallow water with unknown seabed properties and uncertain source depth.	Water	118-123	inositol polyphosphate-5-phosphatase D	Homo sapiens	69-73
32359324-4	2020	The approach is applied to radiated noise due to a container ship recorded on a bottom-moored horizontal array in shallow water.	Water	122-127	inositol polyphosphate-5-phosphatase D	Homo sapiens	61-65
32418389-0	2020	Identification of Free-Living Amoebas in Tap Water of Buildings with Storage Tanks in Korea.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
32418389-6	2020	Five hundred milliliters of tap water from each building was collected and filtered with 0.2 microm pore filter paper.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
32418389-8	2020	We found that 12.9% of tap water from buildings with storage tanks in Korea was contaminated with FLAs.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
32418389-12	2020	Although cases of human infection by V. vermiformis are very rare, we must pay attention to the fact that one-third of tap water supplies in highway service areas have been contaminated.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
31648416-0	2020	Identification of Potential Inhibitors of Cathepsin-B using Shape & Pharmacophore-based Virtual Screening, Molecular Docking and Explicit Water Thermodynamics.	Water	138-143	cathepsin B	Homo sapiens	42-53
31648416-8	2020	The identified inhibitors provided interesting understanding on how the water thermodynamic properties along with hydrophobic, steric, electronic, and structural requirements contribute to cathepsin-B inhibitory activity.	Water	72-77	cathepsin B	Homo sapiens	189-200
31648416-9	2020	These water thermodynamic studies, may further be used in computer aided drug discovery pipeline to design and predict more potent derivatives of various scaffolds as cathepsin-B inhibitors.	Water	6-11	cathepsin B	Homo sapiens	167-178
31997111-0	2020	Peptide transporter2 (PTR2) enhances water uptake during early seed germination in Arabidopsis thaliana.	Water	37-42	peptide transporter 2	Arabidopsis thaliana	0-20
31997111-0	2020	Peptide transporter2 (PTR2) enhances water uptake during early seed germination in Arabidopsis thaliana.	Water	37-42	peptide transporter 2	Arabidopsis thaliana	22-26
31997111-1	2020	KEY MESSAGE: PTR2 in Arabidopsis thaliana is negatively regulated by ABI4 and plays a key role in water uptake by seeds, ensuring that imbibed seeds proceed to germination.	Water	98-103	peptide transporter 2	Arabidopsis thaliana	13-17
31997111-10	2020	Taken together, the results suggest that ABI4-dependent temporal regulation of PTR2 expression may influence water status during seed germination to promote the post-germinative growth of imbibed seeds.	Water	109-114	peptide transporter 2	Arabidopsis thaliana	79-83
32187230-6	2020	Renal GM3 levels were significantly higher in the nephritic MRL/lpr water-treated mice compared to non-nephritic MRL/MpJ mice, despite significantly increased renal NEU activity.	Water	68-73	granulocyte macrophage antigen 3	Mus musculus	6-9
32178707-1	2020	Retinal Muller cells are highly polarized macroglial cells with accumulation of the aquaporin-4 (AQP4) water channel and the inwardly rectifying potassium channel Kir4.1 at specialized endfoot membrane domains abutting microvessels and corpus vitreum.	Water	103-108	aquaporin 4	Mus musculus	84-95
32178707-1	2020	Retinal Muller cells are highly polarized macroglial cells with accumulation of the aquaporin-4 (AQP4) water channel and the inwardly rectifying potassium channel Kir4.1 at specialized endfoot membrane domains abutting microvessels and corpus vitreum.	Water	103-108	aquaporin 4	Mus musculus	97-101
32256194-6	2020	Moreover, these DCreg can regulate the development of EAU by promoting CD4+CD25+Foxp3+ regulatory T cells.	Water	54-57	CD4 antigen	Mus musculus	71-74
32256194-6	2020	Moreover, these DCreg can regulate the development of EAU by promoting CD4+CD25+Foxp3+ regulatory T cells.	Water	54-57	interleukin 2 receptor, alpha chain	Mus musculus	75-79
32401553-0	2020	Ship hull in-water cleaning and its effects on fouling-control coatings.	Water	13-18	inositol polyphosphate-5-phosphatase D	Homo sapiens	0-4
32401553-1	2020	Today, ship hull fouling is managed through fouling-control coatings, complemented with in-water cleaning.	Water	91-96	inositol polyphosphate-5-phosphatase D	Homo sapiens	7-11
31704528-2	2020	Tap water from a drinking water distribution system and ultrafiltrated water were collected and disinfected with four disinfectants (concentrations were set 0.2-1 mg/L as Cl2.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
31704528-10	2020	The level of THM/th and DeltaTHM were lower in ultrafiltrated water than those in tap water.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
31846437-8	2020	Treatment of netrin-1 inhibited H2O2 production derived from NADPH oxidase 4 (Nox4) through the UNC5b/cAMP/PKA signal pathway in AFs remodeling.	Water	32-36	netrin 1	Rattus norvegicus	13-21
31846437-8	2020	Treatment of netrin-1 inhibited H2O2 production derived from NADPH oxidase 4 (Nox4) through the UNC5b/cAMP/PKA signal pathway in AFs remodeling.	Water	32-36	NADPH oxidase 4	Rattus norvegicus	61-76
31846437-8	2020	Treatment of netrin-1 inhibited H2O2 production derived from NADPH oxidase 4 (Nox4) through the UNC5b/cAMP/PKA signal pathway in AFs remodeling.	Water	32-36	NADPH oxidase 4	Rattus norvegicus	78-82
31868639-4	2020	With regard to the nature of water, the degradation rate varied in the order: ultrapure > superficial > tap water.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	104-107
31868639-4	2020	With regard to the nature of water, the degradation rate varied in the order: ultrapure > superficial > tap water.	Water	108-113	nuclear RNA export factor 1	Homo sapiens	104-107
31868639-5	2020	This is due to the presence of organic and inorganic matter (bicarbonates, nitrates, and chlorides) in surface and tap water, that react with the radicals generated, which reduces the availability of radical species, generating competitive kinetics.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
31943512-16	2020	Periodic addition of an effervescent tablet into tap water may be recommended to patients that wear implant retained overdentures with Locator attachments.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
31949029-11	2020	Our study reveals a regulatory role for the miR397b-LAC2 module in root lignification during water and phosphate deficiency.	Water	93-98	MIR397b	Arabidopsis thaliana	44-51
32541118-1	2020	Every year ship traffic produces tons of liquid waste mainly consisting of bilge water and of washing water of tankers" tanks.	Water	81-86	inositol polyphosphate-5-phosphatase D	Homo sapiens	11-15
32541118-1	2020	Every year ship traffic produces tons of liquid waste mainly consisting of bilge water and of washing water of tankers" tanks.	Water	102-107	inositol polyphosphate-5-phosphatase D	Homo sapiens	11-15
32111020-5	2020	The slug flow generated by the interaction of two immiscible fluids {air and water} in two microchannels was investigated.	Water	77-82	snail family transcriptional repressor 2	Homo sapiens	4-8
32102323-2	2020	The TRT isoform of AQP4, named AQP4ex, is central for both AQP4 polarization and water channel activity in the central nervous system (CNS).	Water	81-86	aquaporin 4	Mus musculus	19-23
32102323-2	2020	The TRT isoform of AQP4, named AQP4ex, is central for both AQP4 polarization and water channel activity in the central nervous system (CNS).	Water	81-86	aquaporin 4	Mus musculus	31-35
32093246-1	2020	The influence of the compensating cation (Na+, Li+, Mg2+) nature on the water adsorption properties of LTA and FAU-type zeolites was investigated.	Water	72-77	lymphotoxin alpha	Homo sapiens	103-106
32093246-6	2020	This improvement facilitates the adsorption of water with an increase in the water uptake up to 30% for the LTA and FAU type zeolites exchanged with magnesium.	Water	47-52	lymphotoxin alpha	Homo sapiens	108-111
32093246-6	2020	This improvement facilitates the adsorption of water with an increase in the water uptake up to 30% for the LTA and FAU type zeolites exchanged with magnesium.	Water	77-82	lymphotoxin alpha	Homo sapiens	108-111
32080230-10	2020	We administered either vehicle or IAP (100 U/ml) in drinking water for 14 days in C57BL/6 mice.	Water	61-66	alkaline phosphatase 3, intestine, not Mn requiring	Mus musculus	34-37
31740259-0	2020	An ultrasensitive sensing platform for microRNA-155 based on H2O2 quenched hydroxide-dependent ECL emission of PFO Pdots.	Water	61-65	microRNA 155	Homo sapiens	39-51
31740259-7	2020	With the consumption of H2O2 by hemin/G-quadruplex, the ECL signal would be restored to a signal-on state, thus achieving an ultrasensitive detection of miRNA-155.	Water	24-28	microRNA 155	Homo sapiens	153-162
32570997-5	2020	The concentration of Pb and Cd in tap water samples ranged from ND-0.0250 mg/L and ND-0.0042 mg/L, respectively, from ND-0.005 mg/L and ND- 0.0021 mg/L, respectively, in filtered tap water samples and from ND-0.0400 mg/L and ND-0.0049 mg/L, respectively, in raw water samples.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
32570997-6	2020	The summation of the total hazardous index (HI)-values of bottled water samples, tap water samples, filtered tap water, and raw water samples were less than 1, was considered health-protective.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
32570997-6	2020	The summation of the total hazardous index (HI)-values of bottled water samples, tap water samples, filtered tap water, and raw water samples were less than 1, was considered health-protective.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
32570997-6	2020	The summation of the total hazardous index (HI)-values of bottled water samples, tap water samples, filtered tap water, and raw water samples were less than 1, was considered health-protective.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
31943241-0	2020	Grape seed proanthocyanidins prevent H2 O2 -induced mitochondrial dysfunction and apoptosis via SIRT 1 activation in embryonic kidney cells.	Water	37-42	sirtuin 1	Homo sapiens	96-102
31943241-2	2020	This study evaluated their effects on mitochondrial function, apoptosis, and sirtuin 1 and 3 expressions in HEK-293 cells exposed to H2 O2 .	Water	133-138	sirtuin 1	Homo sapiens	77-92
32550691-6	2020	We found that epinephrine can be safely used for nail surgery, hydrogen peroxide and tap water is recommended for wound cleansing, prophylactic topical antibiotics should be avoided, calcium alginate, or amniotic membrane dressings are valuable dressing alternatives, and digital dressings have a low risk profile with precise technique.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
31943512-11	2020	Following NaOCl (blue; 33.31 +- 4.72 N, clear; 52.3 +- 8.5 N), tap water decreased the retention value of blue (41.14 +- 3.93 N) and clear (76.72 +- 8.42 N) Locator attachments at T3 .	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
31943512-15	2020	Also, tap water remarkably decreased retentive ability of all attachments.	Water	10-15	nuclear RNA export factor 1	Homo sapiens	6-9
31949029-0	2020	The MicroRNA397b -LACCASE2 Module Regulates Root Lignification under Water and Phosphate Deficiency.	Water	69-74	MIR397b	Arabidopsis thaliana	4-16
31949029-6	2020	LAC2 expression was significantly down-regulated under water deficit and posttranscriptionally regulated by microRNA397b (miR397b) in roots under normal and water-deficit conditions.	Water	157-162	MIR397b	Arabidopsis thaliana	108-120
31949029-6	2020	LAC2 expression was significantly down-regulated under water deficit and posttranscriptionally regulated by microRNA397b (miR397b) in roots under normal and water-deficit conditions.	Water	157-162	MIR397b	Arabidopsis thaliana	122-129
16570991-0	2006	Distribution, structure, and dynamics of cesium and iodide ions at the H2O-CCl4 and H2O-vapor interfaces.	Water	71-74	C-C motif chemokine ligand 4	Homo sapiens	75-79
16570991-1	2006	Molecular dynamics simulations utilizing many-body potentials of H2O-CCl4 and H2O-vapor interfaces were carried out at different cesium and iodide ion concentrations to compare ion distribution, interfacial orientational and structural properties, and dynamics.	Water	65-68	C-C motif chemokine ligand 4	Homo sapiens	69-73
16356557-5	2006	Regression analysis showed that increase MAP2 expression was able to explain some of the variance in the behavioral parameters in the water maze suggesting that this cytoskeletal protein probably played a role in mediating enhanced functional outcomes.	Water	134-139	microtubule-associated protein 2	Rattus norvegicus	41-45
32111087-1	2020	Aquaporin-4 (AQP4) is the main water channel protein expressed in the central nervous system (CNS).	Water	31-36	aquaporin 4	Homo sapiens	0-11
32111087-1	2020	Aquaporin-4 (AQP4) is the main water channel protein expressed in the central nervous system (CNS).	Water	31-36	aquaporin 4	Homo sapiens	13-17
32111087-2	2020	AQP4 is densely expressed in astrocyte end-feet, and is an important factor in CNS water and potassium homeostasis.	Water	83-88	aquaporin 4	Homo sapiens	0-4
16580609-5	2006	In these families, mutations have been identified in the aquaporin-2 gene (AQP2) (OMIM 107777), which codes for the vasopressin-sensitive water channel.	Water	138-143	aquaporin 2	Homo sapiens	57-68
31454080-2	2020	Previous studies have demonstrated that the proper recruitment of the water-permeable channel aquaporin-4 (AQP4) to astrocytic endfeet is dependent on interactions between laminin and the receptor dystroglycan.	Water	70-75	aquaporin 4	Homo sapiens	94-105
31454080-2	2020	Previous studies have demonstrated that the proper recruitment of the water-permeable channel aquaporin-4 (AQP4) to astrocytic endfeet is dependent on interactions between laminin and the receptor dystroglycan.	Water	70-75	aquaporin 4	Homo sapiens	107-111
31454080-8	2020	Finally, we showed that laminin111 appears to negatively regulate AQP4-mediated water transport in astrocytes, suppressing the cell swelling that occurs following a hypoosmotic challenge.	Water	80-85	aquaporin 4	Homo sapiens	66-70
16580609-5	2006	In these families, mutations have been identified in the aquaporin-2 gene (AQP2) (OMIM 107777), which codes for the vasopressin-sensitive water channel.	Water	138-143	aquaporin 2	Homo sapiens	75-79
16464879-11	2006	CONCLUSIONS: It seems that C(4) grasses have structurally a superior photosynthate translocation and water distribution system by developing denser networks of small longitudinal and transverse veins, while keeping a constant density of large longitudinal veins.	Water	101-106	complement C4A (Rodgers blood group)	Homo sapiens	27-31
32089675-2	2020	Uroguanylin activates guanylate cyclase-C to regulate intestinal electrolyte and water transport.	Water	81-86	guanylate cyclase activator 2B	Homo sapiens	0-11
16638588-10	2006	As AQP3 is permeable to water, urea, and glycerol, modulation of its expression in fetal membranes may contribute to AF homeostasis.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	3-7
32113276-6	2020	The linear correlation between cavitation inception pressure and water temperature agrees with that given by Vlaisavljevich, Xu, Maxwell, Mancia, Zhang, Lin, Duryea, Sukovich, Hall, Johnsen, and Cain [IEEE Trans.	Water	65-70	calcineurin binding protein 1	Homo sapiens	195-199
31811544-9	2020	In conclusion, our data show that, in collecting duct cells, the water channel Aquaporin-2 modulates NHE1-dependent cell proliferation.	Water	65-70	solute carrier family 9 member A1	Rattus norvegicus	101-105
16423477-0	2006	G-CSF loaded biodegradable PLGA nanoparticles prepared by a single oil-in-water emulsion method.	Water	74-79	colony stimulating factor 3	Homo sapiens	0-5
31999802-0	2020	Correction: Cigarette Smoke Affects Keratinocytes SRB1 Expression and Localization via H2O2 Production and HNE Protein Adducts Formation.	Water	87-91	scavenger receptor class B member 1	Homo sapiens	50-54
31996207-4	2020	Water was categorized as tap or bottled (plain).	Water	0-5	nuclear RNA export factor 1	Homo sapiens	25-28
31996207-11	2020	The main sources of water were tap at home (288 mL/d), tap away from home (301 mL/d), and bottled water from stores (339 mL/d).	Water	20-25	nuclear RNA export factor 1	Homo sapiens	31-34
31996207-13	2020	Higher tap water consumption was associated with higher incomes, but bottled water was not.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
32405304-0	2020	Comprehensive Risk Assessment of Health-Related Hazardous Events in the Drinking Water Supply System from Source to Tap in Gaza Strip, Palestine.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	116-119
32405304-2	2020	Therefore, the transition to a systematic approach in drinking water supply systems management from the source to the consumer tap was taken as a water safety plan (WSP).	Water	146-151	nuclear RNA export factor 1	Homo sapiens	127-130
31909611-3	2020	As intended, these new azole-triazole ligands provide lower field strengths, resulting in high-spin (HS) [FeII(L4NMeIm)3](BF4)2 (1 4H2O) and spin crossover (SCO) active [FeII(L4SIm)3](BF4)2 (2 0.5H2O).	Water	195-199	spindlin 1	Rattus norvegicus	95-99
32021088-1	2020	Purpose: Our previous studies have indicated that non-muscle myosin heavy chain IIA (NMMHC IIA) is involved in H2O2-induced neuronal apoptosis, which is associated with the positive feedback loop of caspase-3/ROCK1/MLC pathway.	Water	111-115	myosin, heavy polypeptide 9, non-muscle	Mus musculus	50-83
32021088-1	2020	Purpose: Our previous studies have indicated that non-muscle myosin heavy chain IIA (NMMHC IIA) is involved in H2O2-induced neuronal apoptosis, which is associated with the positive feedback loop of caspase-3/ROCK1/MLC pathway.	Water	111-115	myosin, heavy polypeptide 9, non-muscle	Mus musculus	85-94
32021088-1	2020	Purpose: Our previous studies have indicated that non-muscle myosin heavy chain IIA (NMMHC IIA) is involved in H2O2-induced neuronal apoptosis, which is associated with the positive feedback loop of caspase-3/ROCK1/MLC pathway.	Water	111-115	caspase 3	Mus musculus	199-208
31404893-5	2020	Due to the mercury ion-promoted transmetalation reaction of aryl boronic acid, this proposed method exhibits fast response, ultra-sensitivity and high selectivity for analysis of Hg2+ in different environmental water, and which also uses to online monitoring of Hg2+.	Water	211-216	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	179-182
32881520-0	2020	Effects of Residual Water in a Linear Quadrupole Ion Trap on the Protonation Sites of 4-Aminobenzoic Acid.	Water	20-25	TRAP	Homo sapiens	53-57
32881520-7	2020	This unexpected result is rationalized based on the formation of long-lived water clusters of varying sizes for the protomers in the quadrupole ion trap due to residual water, low ion kinetic energies, long ion storage times, and relatively high pressure.	Water	76-81	TRAP	Homo sapiens	148-152
32881520-7	2020	This unexpected result is rationalized based on the formation of long-lived water clusters of varying sizes for the protomers in the quadrupole ion trap due to residual water, low ion kinetic energies, long ion storage times, and relatively high pressure.	Water	169-174	TRAP	Homo sapiens	148-152
32881520-8	2020	Further, addition of extra water into the quadrupole ion trap resulted in nearly identical protomer distributions for both protomers.	Water	27-32	TRAP	Homo sapiens	57-61
31869572-1	2020	A water-soluble polysaccharide (ALP) from Acanthopanax leucorrhizus was chemically modified to obtain two sulfated derivatives (S-ALP1 and S-ALP2), two phosphorylated derivatives (P-ALP1 and P-ALP2) and two acetylated derivatives (A-ALP1 and A-ALP2) with different degree of substitution (DS).	Water	2-7	C-C motif chemokine ligand 27	Homo sapiens	32-35
31869572-1	2020	A water-soluble polysaccharide (ALP) from Acanthopanax leucorrhizus was chemically modified to obtain two sulfated derivatives (S-ALP1 and S-ALP2), two phosphorylated derivatives (P-ALP1 and P-ALP2) and two acetylated derivatives (A-ALP1 and A-ALP2) with different degree of substitution (DS).	Water	2-7	alkaline phosphatase, germ cell	Homo sapiens	182-186
31916968-2	2020	He was successfully titrated to CPAP of 10 cm H2O at an outside laboratory and was compliant with therapy with residual AHI 1.9/h.	Water	46-49	centromere protein J	Homo sapiens	32-36
31526351-8	2020	CONCLUSION: Water-soluble vitamins like B1, B3, B6, B7, B9 and B12 have notable effects in diabetes mellitus and its related complications like nephropathy, neuropathy, retinopathy and cardiomyopathy.	Water	12-17	immunoglobulin kappa variable 4-1	Homo sapiens	26-58
31909639-10	2020	Exposure of oocytes to lower HOCl concentrations generated by MPO-H2O2 system prevents MPO-mediated apoptosis whereas exposure to higher HOCl (100 microM) showed apoptosis.	Water	66-70	myeloperoxidase	Mus musculus	62-65
31909639-10	2020	Exposure of oocytes to lower HOCl concentrations generated by MPO-H2O2 system prevents MPO-mediated apoptosis whereas exposure to higher HOCl (100 microM) showed apoptosis.	Water	66-70	myeloperoxidase	Mus musculus	87-90
31735084-5	2020	Generation of superoxide anion and hydrogen peroxide (H2O2) was increased in hypertensive VSMCs, effects associated with activation of redox-sensitive PARP1 (poly [ADP-ribose] polymerase 1), a TRPM2 regulator.	Water	54-58	poly (ADP-ribose) polymerase family, member 1	Mus musculus	151-156
31735084-5	2020	Generation of superoxide anion and hydrogen peroxide (H2O2) was increased in hypertensive VSMCs, effects associated with activation of redox-sensitive PARP1 (poly [ADP-ribose] polymerase 1), a TRPM2 regulator.	Water	54-58	poly (ADP-ribose) polymerase family, member 1	Mus musculus	158-188
31735084-5	2020	Generation of superoxide anion and hydrogen peroxide (H2O2) was increased in hypertensive VSMCs, effects associated with activation of redox-sensitive PARP1 (poly [ADP-ribose] polymerase 1), a TRPM2 regulator.	Water	54-58	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	193-198
31419468-8	2020	Typing of 1,515 isolates from 373 patients and 375 isolates from 81 tap water samples identified 296 pulsotypes.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
31419468-10	2020	The pulsotype identified was previously isolated from another patient and from a tap water sample for 86 and 29 patients respectively.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
31642174-7	2020	In a similar fashion, depression of the E-cadherin/beta-catenin complex mediated by TIMP-3 deletion and knockdown of beta-catenin by small interfering RNA (siRNA) were both capable of inducing caspase activation in isolated hepatocytes subjected to H2 O2 oxidative stress.	Water	249-254	catenin (cadherin associated protein), beta 1	Mus musculus	51-63
31672489-2	2020	Aquaporin-4 (AQP4) is a water channel that is up-regulated in the brain after the ischemic event, but its presence in bloodstream of stroke patients has not been previously studied.	Water	24-29	aquaporin 4	Homo sapiens	0-11
31672489-2	2020	Aquaporin-4 (AQP4) is a water channel that is up-regulated in the brain after the ischemic event, but its presence in bloodstream of stroke patients has not been previously studied.	Water	24-29	aquaporin 4	Homo sapiens	13-17
31655428-1	2020	BACKGROUND: Hydrogen peroxide (H2O2)-induced mitochondrial oxidative damage is critical to intestinal ischemia/reperfusion (I/R) injury, and PRDX3 is an efficient H2O2 scavenger that protects cells from mitochondrial oxidative damage and apoptosis.	Water	31-35	peroxiredoxin 3	Homo sapiens	141-146
31655428-1	2020	BACKGROUND: Hydrogen peroxide (H2O2)-induced mitochondrial oxidative damage is critical to intestinal ischemia/reperfusion (I/R) injury, and PRDX3 is an efficient H2O2 scavenger that protects cells from mitochondrial oxidative damage and apoptosis.	Water	163-167	peroxiredoxin 3	Homo sapiens	141-146
31870869-4	2020	METHODS: Three water-soluble, positively charged porphyrin-like compounds were synthesized and tested for their interaction with the KRAS G-quadruplex by circular dichroism, fluorescence, and molecular docking calculations.	Water	15-20	KRAS proto-oncogene, GTPase	Homo sapiens	133-137
32046059-1	2020	The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.	Water	4-9	aquaporin 4	Mus musculus	26-37
32046059-1	2020	The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.	Water	4-9	aquaporin 4	Mus musculus	39-43
31077338-12	2020	The outermost SC Dsg1 degradation (formation of the BW SC as determined with Dsg1 pixels) was correlated with water-barrier functions and the SC softness of healthy human cheek, which varied widely.	Water	110-115	desmoglein 1	Homo sapiens	17-21
31715260-4	2020	Using this in vitro ischemic-like model, we found that both blockade and interference of CRHR1 inhibited H2O2-enhancd p38, Erk1/2 and cPLA2 phosphorylation and in turn suppressed monolayer hyperpermeability and ZO-1 redistribution.	Water	105-109	corticotropin releasing hormone receptor 1	Mus musculus	89-94
31816386-6	2020	In this study, we found that curcumin can effectively ameliorate hydrogen peroxide (H2O2)-induced oxidative stress, intestinal epithelial barrier injury and mitochondrial damage in porcine intestinal epithelial cells (IPEC-J2 cells) in a PTEN-induced putative kinase (PINK1)-Parkin mitophagy dependent way.	Water	84-88	parkin RBR E3 ubiquitin protein ligase	Sus scrofa	275-281
31816386-7	2020	Mechanistically, depletion of Parkin (a mitophagy related protein) abolished curcumin"s protective action on anti-oxidative stress, improving intestinal barrier and mitochondrial function in porcine intestinal epithelial cells (IPEC-J2) induced by H2O2.	Water	248-252	parkin RBR E3 ubiquitin protein ligase	Sus scrofa	30-36
31941613-0	2020	Resveratrol induces SIRT1-Dependent autophagy to prevent H2O2-Induced oxidative stress and apoptosis in HTR8/SVneo cells.	Water	57-61	sirtuin 1	Homo sapiens	20-25
31941613-11	2020	Mechanistically, RES restored the levels of SIRT1 and autophagy-related proteins including LC3-II, Beclin-1 and p62 that were dysregulated by H2O2.	Water	142-146	sirtuin 1	Homo sapiens	44-49
31941613-11	2020	Mechanistically, RES restored the levels of SIRT1 and autophagy-related proteins including LC3-II, Beclin-1 and p62 that were dysregulated by H2O2.	Water	142-146	beclin 1	Homo sapiens	99-107
31941613-11	2020	Mechanistically, RES restored the levels of SIRT1 and autophagy-related proteins including LC3-II, Beclin-1 and p62 that were dysregulated by H2O2.	Water	142-146	nucleoporin 62	Homo sapiens	112-115
31872818-3	2020	Herein, molecular dynamics simulations of a dynein motor disclosed that two water molecules are present close to the gamma-phosphate of ATP and Glu1742 at the AAA1 site of dynein.	Water	76-81	AAA1	Homo sapiens	159-163
32121855-1	2020	The presence of a ship in water disturbs the ambient light field and propagates errors to radiometric measurements.	Water	26-31	inositol polyphosphate-5-phosphatase D	Homo sapiens	18-22
31566368-1	2020	The mixed-ligand system consisting of tris(2-aminoethyl)amine (TREN) and tris(2-dimethylaminoethyl)amine (Me6-TREN) during the Cu(0) wire-catalyzed single electron transfer-living radical polymerization (SET-LRP) of methyl acrylate (MA) in "programmed" biphasic mixtures of the dipolar aprotic solvents NMP, DMF, and DMAc with H2O is reported.	Water	327-330	protocadherin gamma subfamily B, 7	Homo sapiens	106-109
32190275-2	2020	We report on the performance of a newly designed n-butyl-arylazopyrazole butyl sulfonate (butyl-AAP-C4S) surfactant that can change its structure at the air-water interface by E/Z photo-isomerization in an unprecedented way.	Water	157-162	serpin family F member 2	Homo sapiens	96-99
31912804-9	2020	Furthermore, when compared to the Dex group, there were significant increases of H2O2, MDA, NO, IL-1ss, TNF-alpha, IL-6, IL-8, HMGB1, TLR4, and p-P65 in the rHMGB1 group and rHMGB1+Dex group, in which a significant decrease of T-AOC, SOD, and p-IkappaBalpha was also detected.	Water	81-85	high mobility group box 1	Rattus norvegicus	157-163
31445806-7	2020	In DOC water, losses to the filter increased by 3.8%, 5.1%, and 8.4% per CF2-moiety for C3-C11 perfluoroalkyl carboxylates (PFCAs), perfluoroalkyl sulfonates (PFSAs), and fluorotelomer sulfonic acids (FTSAs), respectively.	Water	7-12	ATPase H+ transporting accessory protein 1	Homo sapiens	73-76
31599077-4	2020	However, here we show that deletion of CTK complex components in Neurospora led to high CAT-3 expression level and resistance to H2 O2 -induced ROS stress.	Water	129-134	megakaryocyte-associated tyrosine kinase	Homo sapiens	39-42
31639438-10	2020	Liver mitochondria collected from 6NJ mice, on the other hand, were more reliant on the GSH and TRX systems to clear exogenously added H2O2.	Water	135-139	thioredoxin 1	Mus musculus	96-99
31682917-4	2020	For example, TRPM2, TRPC5, TRPV1, and TRPA1 are known as redox sensors activated by hydrogen peroxide (H2O2), nitric oxide (NO), and electrophiles.	Water	103-107	transient receptor potential cation channel subfamily M member 2	Homo sapiens	13-18
31318730-9	2020	The range of thyroid doses to Iitate Village residents was similar to that to Iwaki City residents even though the I concentration in tap water was much higher in Iitate Village than Iwaki City.	Water	138-143	nuclear RNA export factor 1	Homo sapiens	134-137
32604456-2	2020	All elements of a ship"s water supply chain are exposed to the influence of different factors that may have a negative impact on water safety on board or on human health.	Water	25-30	inositol polyphosphate-5-phosphatase D	Homo sapiens	18-22
32604456-2	2020	All elements of a ship"s water supply chain are exposed to the influence of different factors that may have a negative impact on water safety on board or on human health.	Water	129-134	inositol polyphosphate-5-phosphatase D	Homo sapiens	18-22
32604456-9	2020	Regardless of the sanitary control system used by the authorised institutions on the ground, ship officers must oversee the entire water supply and distribution system on board, as well the water production systems if these exist.	Water	131-136	inositol polyphosphate-5-phosphatase D	Homo sapiens	93-97
32604456-9	2020	Regardless of the sanitary control system used by the authorised institutions on the ground, ship officers must oversee the entire water supply and distribution system on board, as well the water production systems if these exist.	Water	190-195	inositol polyphosphate-5-phosphatase D	Homo sapiens	93-97
31478134-8	2020	ANF could significantly reduce the Evans blue extravasation and water content in the ipsilateral hemisphere and obviously increase the occludin, claudin-5, and ZO-1 expression after cerebral I/R injury.	Water	64-69	natriuretic peptide A	Rattus norvegicus	0-3
30430614-5	2020	Most of this knowledge has been gathered from the study of AQP4, the best characterized AQP and the one that has the biggest impact on water movement.	Water	135-140	aquaporin 4	Homo sapiens	59-63
32016893-6	2020	Integration of GPCR crystallography or homology modelling with FMO reveals atomistic details of the individual contributions of each residue and water molecule toward ligand binding, including an analysis of their chemical nature.	Water	145-150	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	15-19
31707353-8	2020	Impaired inflammasome activation in G6PD-kd THP-1 cells was mediated by a decrease in the production of reactive oxygen species (ROS) by NOX signaling, while treatment with hydrogen peroxide (H2O2) enhanced inflammasome activation in G6PD-kd THP-1 cells.	Water	192-196	glucose-6-phosphate dehydrogenase	Homo sapiens	234-238
31505354-11	2020	The results showed that some of the technique, if implemented as part of the water safety management, can detect rapidly the most common waterborne pathogens and fecal pollution indicators and therefore have a great early warning potential; can improve water safety for the consumer; can validate whether mitigation methods are working as intended; and can confirm the quality of the water at source and at the tap.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	411-414
16480680-2	2006	In a previous study, we found that acetazolamide could inhibit osmotic water transportation across Xenopus oocytes by blocking the function of aquaporin-1 (AQP1).	Water	71-76	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	143-154
31505354-11	2020	The results showed that some of the technique, if implemented as part of the water safety management, can detect rapidly the most common waterborne pathogens and fecal pollution indicators and therefore have a great early warning potential; can improve water safety for the consumer; can validate whether mitigation methods are working as intended; and can confirm the quality of the water at source and at the tap.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	411-414
31505354-11	2020	The results showed that some of the technique, if implemented as part of the water safety management, can detect rapidly the most common waterborne pathogens and fecal pollution indicators and therefore have a great early warning potential; can improve water safety for the consumer; can validate whether mitigation methods are working as intended; and can confirm the quality of the water at source and at the tap.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	411-414
32213722-5	2020	Control samples were taken before and after the prescribed flushing from another high-speed handpiece (HS-2) that is directly supplied with tap water in the same dental unit.	Water	144-149	nuclear RNA export factor 1	Homo sapiens	140-143
32213722-9	2020	RESULTS: SAEW always showed a higher free chlorine concentration than tap water during the observation period of 7 years.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
32213722-10	2020	In HS-2 supplied with tap water, the free chlorine concentration increased significantly owing to the prescribed flushing.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
32213722-11	2020	SAEW always showed a significantly smaller number of heterotrophic bacteria than tap water.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
32592576-3	2020	The contribution of resort doctors, geologists, employees of research institutes to the study of the mechanism of action and clinical effectiveness of the use of Tal mineral water is described.	Water	174-179	transaldolase 1	Homo sapiens	162-165
16480680-2	2006	In a previous study, we found that acetazolamide could inhibit osmotic water transportation across Xenopus oocytes by blocking the function of aquaporin-1 (AQP1).	Water	71-76	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	156-160
31926619-5	2020	Mechanistically, Gpx1 interacts with FAK kinase and prevents the kinase inactivation by H2O2, not lipid hydroperoxide.	Water	88-92	glutathione peroxidase 1	Homo sapiens	17-21
16548507-2	2006	The reviewed studies provide fundamental insight on long-standing problems regarding the assembly and function of the individual residues and bound water molecules that form the rhodopsin active site, a center that catalyzes the 11-cis/all-trans isomerization of the retinyl chromophore in the primary step of the phototransduction mechanism.	Water	148-153	rhodopsin	Bos taurus	178-187
31491637-1	2019	Although human exposure to perfluoroalkyl acids (PFAAs) through tap water is an ongoing concern, knowledge of the PFAAs occurrence in the tap water and the associated transport behaviors of PFAAs in drinking water distribution systems (DWDSs) are scarce.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
31491637-1	2019	Although human exposure to perfluoroalkyl acids (PFAAs) through tap water is an ongoing concern, knowledge of the PFAAs occurrence in the tap water and the associated transport behaviors of PFAAs in drinking water distribution systems (DWDSs) are scarce.	Water	142-147	nuclear RNA export factor 1	Homo sapiens	138-141
16505230-3	2006	GNG(PEP) (via phosphoenol pyruvate [PEP]) was measured after a 17-h fast using the deuterated water method and 2H nuclear magnetic resonance spectroscopy of plasma glucose.	Water	94-99	progestagen associated endometrial protein	Homo sapiens	0-8
31491637-1	2019	Although human exposure to perfluoroalkyl acids (PFAAs) through tap water is an ongoing concern, knowledge of the PFAAs occurrence in the tap water and the associated transport behaviors of PFAAs in drinking water distribution systems (DWDSs) are scarce.	Water	142-147	nuclear RNA export factor 1	Homo sapiens	138-141
31491637-3	2019	Tap water samples both along trunk pipelines and at the distal ends were collected to display the PFAAs occurrence scenarios.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
31491637-5	2019	The results showed that perfluorooctanoic acid (PFOA) and perfluorobutanoic acid (PFBA) widely existed in tap water samples, and were the predominant PFAAs in eastern China areas.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	106-109
31491637-11	2019	When water quality conditions change or hydraulic disturbance occur, loose deposits may enter tap water bringing accumulated PFAAs with it, which may result in potential health risks.	Water	5-10	nuclear RNA export factor 1	Homo sapiens	94-97
31491637-11	2019	When water quality conditions change or hydraulic disturbance occur, loose deposits may enter tap water bringing accumulated PFAAs with it, which may result in potential health risks.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
32248159-6	2020	CONCLUSION: Conclusions: Results of sociological survey shown that among rural residents increased the demand for a consumption of pre-treated drinking water, due to the deterioration quality of tap water in the rural area.	Water	152-157	nuclear RNA export factor 1	Homo sapiens	195-198
32248159-6	2020	CONCLUSION: Conclusions: Results of sociological survey shown that among rural residents increased the demand for a consumption of pre-treated drinking water, due to the deterioration quality of tap water in the rural area.	Water	199-204	nuclear RNA export factor 1	Homo sapiens	195-198
31902877-6	2020	Hypoxia enhanced H2O2-induced TRPA1 responses in human TRPA1-expressing cells and cultured mouse dorsal root ganglion neurons, with this hypoxia-induced TRPA1 sensitization to H2O2 being associated with hypoxia-induced inhibition of the hydroxylation of prolyl hydroxylases.	Water	17-21	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	55-60
16478190-1	2006	D(2)O-grown crystals of yeast zinc porphyrin substituted cytochrome c peroxidase (ZnCcP) in complex with yeast iso-1-cytochrome c (yCc) diffract to higher resolution (1.7 A) and pack differently than H(2)O-grown crystals (2.4-3.0 A).	Water	200-205	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	111-116
31902877-6	2020	Hypoxia enhanced H2O2-induced TRPA1 responses in human TRPA1-expressing cells and cultured mouse dorsal root ganglion neurons, with this hypoxia-induced TRPA1 sensitization to H2O2 being associated with hypoxia-induced inhibition of the hydroxylation of prolyl hydroxylases.	Water	176-180	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	55-60
31742265-5	2019	The RET from CdS NWs to Au NPs and the coreactant (i.e. H2O2) consumption by the CAT generate a significant ECL decrease on the CdS NWs-based electrode in the presence of cTnI.	Water	56-60	troponin I3, cardiac type	Homo sapiens	171-175
16471821-4	2006	By treating two hydrogen molecules or four hydrogen molecules as one rigid body cluster, we determine ab initio binding energies between water molecules and hydrogen clusters at the MP2 level with the 6-31++G(2d,2p) basis set.	Water	137-142	tryptase pseudogene 1	Homo sapiens	182-185
31474661-0	2019	Preparation of a Reference Material for the Determination of Hexavalent Chromium in Tap Water.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
31877897-6	2019	As a consequence of this, ganglioside GT1b and GM1 decrease DNA fragmentation and act as H2O2 inhibitors on germ cells and preimplantation embryos.	Water	89-93	coenzyme Q10A	Mus musculus	47-50
32030182-0	2019	Human health risk assessment of trace elements in drinking tap water in Zahedan city, Iran.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
16144968-8	2006	The data imply that polydipsia in STR/N mice may have affected AQP2 mRNA transcription in the kidney, resulting in reduced AQP2 expression, which would contribute to a reduction in overretention of water.	Water	198-203	aquaporin 2	Mus musculus	63-67
32030182-2	2019	Although the health risk assessment of heavy metals in different water sources has extensively carried out in various studies, the effect of age and the concentration of all trace elements in drinking tap water have neglected.	Water	205-210	nuclear RNA export factor 1	Homo sapiens	201-204
32030182-4	2019	Moreover, this is the first research in Iran that has also been dedicated to complete investigation on daily intakes of trace elements in tap water.	Water	142-147	nuclear RNA export factor 1	Homo sapiens	138-141
31856722-5	2019	Same time bacterial diversity of tap water, connected to the dishwashers was investigated.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
31835456-6	2019	Consistently, in the H2O2-treated IPEC-1 cells, fucoidan normalized the content of reduced glutathione as well as the mRNA abundance of NAD(P)H quinone dehydrogenase 1 and superoxide dismutase 1 while it prevented the overproduction of malondialdehyde.	Water	21-25	NAD(P)H quinone dehydrogenase 1	Sus scrofa	136-167
31812951-4	2019	In SH-SY5Y neuronal cells and primary human neuron cultures, H2O2 downregulated Lnc-EPIC1 and key MYC targets (Cyclin A1, CDC20 and CDC45).	Water	61-65	cell division cycle 20	Homo sapiens	122-127
31856722-11	2019	The bacterial diversity of tap water was also lower, 23 genera compared to 39 genera on dishwasher rubber seals.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
31856722-12	2019	Only 13 out of 49 genera identified by metagenomics approach was found in both environments, of those Gordonia was enriched while half of 13 genera were depleted in dishwashers compared to tap water.	Water	193-198	nuclear RNA export factor 1	Homo sapiens	189-192
16144968-8	2006	The data imply that polydipsia in STR/N mice may have affected AQP2 mRNA transcription in the kidney, resulting in reduced AQP2 expression, which would contribute to a reduction in overretention of water.	Water	198-203	aquaporin 2	Mus musculus	123-127
16467332-4	2006	Expression of the LF gene was lower in mice administered LF than in mice administered water or BSA, implying a negative-feedback control.	Water	86-91	lactotransferrin	Mus musculus	18-20
16261609-2	2006	Mice deficient in ERalpha (alphaERKO mice) are infertile, and the effect appears to be due in part to retention of water at the level of the efferent ductules.	Water	115-120	estrogen receptor 1 (alpha)	Mus musculus	18-25
31589250-10	2019	In multivariable-adjusted analyses, fish oil supplementation and fatty cold water fish intake were positively associated with DHA and the "high n-3 PUFA" pattern.	Water	76-81	pumilio RNA binding family member 3	Homo sapiens	148-152
16471698-1	2006	The structure of the complex of cyclophilin A (CypA) with cyclosporin A (CsA, 1) shows a cluster of four water molecules buried at the binding interface, which is rearranged when CsA is replaced by (5-hydroxynorvaline)-2-cyclosporin (2).	Water	105-110	peptidylprolyl isomerase A	Homo sapiens	32-45
31603005-9	2019	Ascended miR-26a was monitored in Sal-B and H2O2-exposed cells.	Water	44-48	microRNA 26a	Rattus norvegicus	9-16
31603005-10	2019	MiR-26a inhibition annulled the protective action of Sal-B in H2O2-corrupted cells.	Water	62-66	microRNA 26a	Rattus norvegicus	0-7
16471698-1	2006	The structure of the complex of cyclophilin A (CypA) with cyclosporin A (CsA, 1) shows a cluster of four water molecules buried at the binding interface, which is rearranged when CsA is replaced by (5-hydroxynorvaline)-2-cyclosporin (2).	Water	105-110	peptidylprolyl isomerase A	Homo sapiens	47-51
31603005-12	2019	These findings delineated that Sal-B protected PC-12 cells against H2O2-caused injury through ascending miR-26a via initiating PI3K/AKT and MEK/ERK pathways.	Water	67-71	microRNA 26a	Rattus norvegicus	104-111
16405316-11	2006	The CCSD(T)-PES and MP2-DMS dissociate correctly (and symmetrically) to two H2O monomers, with D(e) = 1665.7 cm(-1) (19.93 kJ/mol).	Water	76-79	tryptase pseudogene 1	Homo sapiens	20-23
31394442-6	2019	Moreover, the degradation of FLU in different water matrices were also explored, and the removal followed the order of Tap water > Ultrapure water > River water > Secondary clarifier effluent.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
31394442-6	2019	Moreover, the degradation of FLU in different water matrices were also explored, and the removal followed the order of Tap water > Ultrapure water > River water > Secondary clarifier effluent.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
31394442-6	2019	Moreover, the degradation of FLU in different water matrices were also explored, and the removal followed the order of Tap water > Ultrapure water > River water > Secondary clarifier effluent.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
16471582-2	2006	Adopting a lattice gas model for water, we simulated water menisci that form between a rough silicon-nitride tip and a mica surface.	Water	53-58	TOR signaling pathway regulator	Homo sapiens	109-112
31601978-5	2019	Consequently, two cytokinin downstream type-A response regulators, ARR16 and ARR17, were found to be up-regulated at the lower water potential side, causing increased cell division in the meristem zone, which allows the root to bend towards higher water potential side.	Water	127-132	response regulator 16	Arabidopsis thaliana	67-72
31601978-5	2019	Consequently, two cytokinin downstream type-A response regulators, ARR16 and ARR17, were found to be up-regulated at the lower water potential side, causing increased cell division in the meristem zone, which allows the root to bend towards higher water potential side.	Water	248-253	response regulator 16	Arabidopsis thaliana	67-72
16206160-6	2006	The water channel aquaporin-4 (AQP4) also appears to be important for [K+]o buffering and is expressed in Muller cells in a very similar subcellular distribution pattern to that of Kir4.1.	Water	4-9	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	181-187
31585206-5	2019	In this study, we found that the protein expression of circadian genes Clock, Bmal1, Per1/2, and Cry1/2 in NIH3T3 cells was upregulated by hydrogen peroxide (H2O2), an important mediator of oxidative stress.	Water	158-162	cryptochrome 1 (photolyase-like)	Mus musculus	97-101
31585206-6	2019	In addition, H2O2 modulated the circadian rhythm of Bmal1-luciferase via RORalpha, REV-ERBalpha (NR1D1), and REV-ERBbeta (NR1D2).	Water	13-17	nuclear receptor subfamily 1, group D, member 1	Mus musculus	83-95
16392856-3	2006	Water molecules were included in the cluster to investigate the influence of explicit solvation on proton-transfer reactions and on the energy associated with hydroxylating the bridging oxygen atom (Obr).	Water	0-5	leptin receptor	Homo sapiens	199-202
31585206-6	2019	In addition, H2O2 modulated the circadian rhythm of Bmal1-luciferase via RORalpha, REV-ERBalpha (NR1D1), and REV-ERBbeta (NR1D2).	Water	13-17	nuclear receptor subfamily 1, group D, member 1	Mus musculus	97-102
16461188-10	2006	CONCLUSIONS: These results indicate that AQP4 may play a much more important role in BBB function than GLUT-1, and thereby also in water distribution in the cerebral cortex of SHRSP with severe hypertension.	Water	131-136	aquaporin 4	Rattus norvegicus	41-45
31190144-1	2019	The bidirectional water channel aquaporin 4 (AQP4) is abundantly expressed in the neural tissue.	Water	18-23	aquaporin 4	Mus musculus	45-49
16487059-4	2006	We have used the TIP3 model for water and OPLS for the nucleic acid bases.	Water	32-37	suppressor of cytokine signaling 1	Homo sapiens	17-21
16081318-7	2006	RESULTS: Twitch Pdi at baseline was 20.2 +/- 6.7 cm H2O in the CHF group and 20.3 +/- .3 cm H2O in the controls (p = 0.957).	Water	52-55	peptidyl arginine deiminase 1	Homo sapiens	16-19
31659341-5	2019	Leucokinin inhibits two types of mushroom-body-innervating dopaminergic neurons (DANs) to promote thirst-specific water memory expression, whereas it activates other mushroom-body-innervating DANs to facilitate hunger-dependent sugar memory expression.	Water	114-119	Leucokinin	Drosophila melanogaster	0-10
16339784-6	2006	Quantification of low water potential-induced ABA and Pro accumulation in five ABA-insensitive mutants, abi1-1, abi2-1, abi3, abi4, and abi5, revealed that abi4 had increased Pro accumulation at low water potential, but a reduced response to exogenous ABA.	Water	22-27	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	120-124
31747128-1	2019	Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O2 ) to produce hydrogen peroxide (H2 O2 ) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation.	Water	106-111	hydroxyacid oxidase 1	Homo sapiens	0-15
31747128-1	2019	Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O2 ) to produce hydrogen peroxide (H2 O2 ) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation.	Water	106-111	hydroxyacid oxidase 1	Homo sapiens	17-20
31450413-3	2019	The probe is a water-soluble molecule consisting of an UV-absorptive aromatic anthraquinone (Aq) and a GGT cleavable glutathione (ECG) via one-step thiol-ene reaction covalently linked together.	Water	15-20	inactive glutathione hydrolase 2	Homo sapiens	103-106
16339784-6	2006	Quantification of low water potential-induced ABA and Pro accumulation in five ABA-insensitive mutants, abi1-1, abi2-1, abi3, abi4, and abi5, revealed that abi4 had increased Pro accumulation at low water potential, but a reduced response to exogenous ABA.	Water	22-27	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	136-140
16954599-1	2006	Prunus persica L. Batsch water extract (PPE) is a potent acetylcholinesterase (AChE) inhibitor screened for the treatment of Alzheimer"s disease.	Water	25-30	acetylcholinesterase	Rattus norvegicus	79-83
16575466-4	2006	Water-soluble fluvastatin was used at concentrations (0-800 ng/ml) against human umbilical vein endothelial cells (HUVEC), and several well-characterized cancer cell lines in culture, including: carcinoma (LLC), melanoma (B16F1) and fibrosarcoma driven by mutant H-ras (528ras1).	Water	0-5	HRas proto-oncogene, GTPase	Homo sapiens	263-268
31783479-5	2019	Phosphoproteomic analysis showed that CeO2NPs reverted the H2O2-mediated increase in the phosphorylation of peptides related to cellular proliferation, stress response, and gene transcription regulation, and interfered with H2O2 effects on mTOR, MAPK/ERK, CK2A1 and PKACA signaling pathways.	Water	59-63	protein kinase cAMP-activated catalytic subunit alpha	Homo sapiens	266-271
31776798-4	2019	TYR catalyzes the oxidation of DA while CAT can decompose H2O2 into water and oxygen.	Water	58-62	tyrosinase	Homo sapiens	0-3
17150915-7	2006	These results suggest that PPARalpha regulates fatty acid metabolism and body water homeostasis in this cell line.	Water	78-83	peroxisome proliferator activated receptor alpha	Homo sapiens	27-36
17278780-1	2006	UNLABELLED: Leptin seems to play a role in the pathogenesis of arterial hypertension by activation of the sympathetic nervous system, influencing water - electrolyte balance and vascular remodeling.	Water	146-151	leptin	Homo sapiens	12-18
31400719-10	2019	While those are some differences among tap waters inlet from the same water sources.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
32782938-3	2020	Tacrolimus is topically active, water soluble, and has minimal systemic toxicity when administered rectally; we therefore tested a simple tap water-based enema formulation.	Water	142-147	nuclear RNA export factor 1	Homo sapiens	138-141
31817716-0	2019	H2O2 as a Feedback Signal on Dual-Located WHIRLY1 Associates with Leaf Senescence in Arabidopsis.	Water	0-4	ssDNA-binding transcriptional regulator	Arabidopsis thaliana	42-49
31817716-5	2019	Here, we provide further evidence in Arabidopsis showing that alteration in WHY1 allocation between the nucleus and chloroplast causes perturbation in H2O2 homeostasis, resulting in adverse plant senescence phenotypes.	Water	151-155	ssDNA-binding transcriptional regulator	Arabidopsis thaliana	76-80
31817716-6	2019	The knockout of WHY1 increased H2O2 content at 37 days post-germination, coincident with an early leaf senescence phenotype, which can be rescued by ectopic expression of the nuclear isoform (nWHY1), but not by the plastid isoform (pWHY1).	Water	31-35	ssDNA-binding transcriptional regulator	Arabidopsis thaliana	16-20
31817716-8	2019	On the other hand, exogenous H2O2 treatment induced a substantial plastid accumulation of WHY1 proteins and at the same time reduced the nuclear isoforms.	Water	29-33	ssDNA-binding transcriptional regulator	Arabidopsis thaliana	90-94
31817716-9	2019	This H2O2-induced loss of nucleus WHY1 isoform was accompanied by enhanced enrichments of histone H3 lysine 9 acetylation (H3K9ac) and recruitment of RNA polymerase II (RNAP II) globally, and specifically at the promoter of the senescence-related transcription factor WRKY53, which in turn activated WRKY53 transcription and led to a senescence phenotype.	Water	5-9	ssDNA-binding transcriptional regulator	Arabidopsis thaliana	34-38
16752765-6	2006	Nak-dong River was used as the filter influent water and alum, PSOM, and PAC were used as the coagulants.	Water	47-52	TANK binding kinase 1	Homo sapiens	0-3
31792614-10	2019	The methods were applied to the sensitive determination of glucose by using glucose oxidase (GOx) which catalyzes the oxidization of glucose to produce H2O2.	Water	152-156	hydroxyacid oxidase 1	Homo sapiens	76-91
31792614-10	2019	The methods were applied to the sensitive determination of glucose by using glucose oxidase (GOx) which catalyzes the oxidization of glucose to produce H2O2.	Water	152-156	hydroxyacid oxidase 1	Homo sapiens	93-96
31766178-8	2019	This study may inspire other novel applications of micro-analytical devices for utilization of microalgae resources, marine ecological environment protection and ship ballast water management.	Water	175-180	inositol polyphosphate-5-phosphatase D	Homo sapiens	162-166
16288724-0	2005	Effect on stability, degradation, expression, and targeting of aquaporin-2 water channel by hyperosmolality in renal epithelial cells.	Water	75-80	aquaporin 2	Mus musculus	63-74
31409458-5	2019	Excellent predictions were obtained for the determination of hydroquinone and catechol in the direct analysis of spiked tap water samples with EIS and complex numbers-PLS.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
31423748-2	2019	The study was designed to test the hypothesis that nephrotic proteinuria in mice after conditional deletion of podocin leads to urokinase-dependent, amiloride-sensitive plasmin-mediated sodium and water retention.	Water	197-202	nephrosis 2, podocin	Mus musculus	111-118
16354044-1	2005	The bending vibrational spectrum of the perdeutero isotopomer of the water trimer anion has been measured and compared with spectra calculated using the MP2, CCSD, and Becke3LYP electronic structure methods.	Water	69-74	tryptase pseudogene 1	Homo sapiens	153-156
31717290-4	2019	Water was categorized as tap or bottled.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	25-28
16396537-2	2005	The structures of the two low-energy conformers of CNN-H2O and CNN-(H2O)2, calculated at the MP2/cc-pVDZ level of theory, are consistent with the mass-selective infrared-ultraviolet double-resonance spectra and the partially resolved rotational band contours of the S1 &lt;-- S0 origin bands.	Water	55-58	tryptase pseudogene 1	Homo sapiens	93-96
31694346-7	2019	Additionally, the exposure of human sperm to H2O2 resulted in a significant decrease in sperm viability and motility and an increase in the levels of HSF1, HSP90, HSP60, HSP27, and eIF2alpha; all proteins involved in sensing and response to unfolded proteins.	Water	45-49	heat shock protein family D (Hsp60) member 1	Homo sapiens	163-168
31694346-7	2019	Additionally, the exposure of human sperm to H2O2 resulted in a significant decrease in sperm viability and motility and an increase in the levels of HSF1, HSP90, HSP60, HSP27, and eIF2alpha; all proteins involved in sensing and response to unfolded proteins.	Water	45-49	eukaryotic translation initiation factor 2A	Homo sapiens	181-190
31310699-0	2019	Water to prevent kidney stones: tap vs bottled; soft vs hard - does it matter?	Water	0-5	nuclear RNA export factor 1	Homo sapiens	32-35
16323936-4	2005	Upon reaction of LLi2 with [Ti(NMe2)2Cl2] and water, the mu-oxo-bridged dititanium species [L[Ti(NMe2)Cl]2(mu-O)] is obtained in excellent yield (X-ray crystal structure analysis).	Water	46-51	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	31-35
31646444-6	2019	Altogether, enhanced NOX2 activation/mitochondrial dysfunction led to reduced survival of human and mice neutrophils, due to H2O2 accumulation, S-glutathionylation of catalase, and reduction in its enzymatic activity.	Water	125-129	cytochrome b-245 beta chain	Homo sapiens	21-25
31815867-3	2019	Real-time PCR (RT-PCR) was used to determine the relative RNA expression of NEAT1 and its potential target microRNA, miR-129-5p, in the plasma of patients with acute myocardial infarction, heart failure, and angina, as well as in H2O2-treated H9c2 cells.	Water	230-234	nuclear paraspeckle assembly transcript 1	Homo sapiens	76-81
31815867-3	2019	Real-time PCR (RT-PCR) was used to determine the relative RNA expression of NEAT1 and its potential target microRNA, miR-129-5p, in the plasma of patients with acute myocardial infarction, heart failure, and angina, as well as in H2O2-treated H9c2 cells.	Water	230-234	microRNA 1295a	Homo sapiens	117-127
31815867-10	2019	In conclusion, we uncovered a novel NEAT1-miR-129 axis and its implication in H2O2-induced heart failure.	Water	78-82	nuclear paraspeckle assembly transcript 1	Homo sapiens	36-41
31212194-6	2019	This method shows great promise for on-site analysis and in-house diagnosis of Hg2+ in water.	Water	87-92	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	79-82
31226617-8	2019	Furthermore, the fluorescence method is successfully used to detect Hg2+ in actual water samples and biothiols in human plasma.	Water	83-88	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	68-71
16323936-4	2005	Upon reaction of LLi2 with [Ti(NMe2)2Cl2] and water, the mu-oxo-bridged dititanium species [L[Ti(NMe2)Cl]2(mu-O)] is obtained in excellent yield (X-ray crystal structure analysis).	Water	46-51	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	97-101
15998844-0	2005	Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice.	Water	10-15	aquaporin 7	Mus musculus	66-70
31196337-6	2019	The results showed that the microemulsions containing the most polar surfactant (NP95) caused greater stabilization of the O/W emulsion (produced water).	Water	146-151	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	81-85
15998844-1	2005	The aquaporin-7 (AQP7) water channel is known as a member of the aquaglyceroporins, which facilitate the transport of glycerol as well as water.	Water	23-28	aquaporin 7	Mus musculus	4-15
31702805-2	2019	Although miRNA-21-5p has previously been reported to decrease H2O2-induced AEC II apoptosis by targeting PTEN in vitro, whether miR-21-5p can decrease HALI in vivo and the downstream molecular mechanisms remain unclear.	Water	62-66	phosphatase and tensin homolog	Rattus norvegicus	105-109
33708297-15	2019	Provision of safe water for the community by strictly conducting end-point assessment of water points and conducting a KAP assessment among food handlers to explore their knowledge and practices regarding safe food/drink handling and water treatment as well as initiate appropriate PH actions based on the findings which will be necessary for prevention of similar cholera outbreaks in the future.	Water	18-23	cyclin dependent kinase inhibitor 3	Homo sapiens	119-122
15998844-1	2005	The aquaporin-7 (AQP7) water channel is known as a member of the aquaglyceroporins, which facilitate the transport of glycerol as well as water.	Water	23-28	aquaporin 7	Mus musculus	17-21
15998844-1	2005	The aquaporin-7 (AQP7) water channel is known as a member of the aquaglyceroporins, which facilitate the transport of glycerol as well as water.	Water	138-143	aquaporin 7	Mus musculus	4-15
31398650-4	2019	The optimized method was applied to analyze VOCs in tap water samples collected from Wuhan City, China.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
15998844-1	2005	The aquaporin-7 (AQP7) water channel is known as a member of the aquaglyceroporins, which facilitate the transport of glycerol as well as water.	Water	138-143	aquaporin 7	Mus musculus	17-21
31398650-8	2019	Untargeted analysis of the tap water samples identified 75-200 VOCs, including 67 highly prevalent compounds.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
31656733-6	2019	H2O2 facilitates the regulation of different stress-responsive transcription factors (TFs) including NAC, Zinc finger, WRKY, ERF, MYB, DREB and bZIP as both upstream and downstream events during stress signalling.	Water	0-4	X-linked Kx blood group	Homo sapiens	101-104
15998844-4	2005	The water permeability of the proximal tubule brush-border membrane measured by the stopped-flow method was slightly but significantly reduced in the AQP7 knockout mice compared with that of wild-type mice (AQP7, 18.0 +/- 0.4 x 10(-3) cm/s vs. wild-type, 20.0 +/- 0.3 x 10(-3) cm/s).	Water	4-9	aquaporin 7	Mus musculus	150-154
15998844-5	2005	Although AQP7 solo-knockout mice did not exhibit a urinary concentrating defect, AQP1/AQP7 double-knockout mice had a reduction in urinary concentrating ability compared with AQP1 solo-knockout mice, suggesting that the amount of water reabsorbed through AQP7 in the proximal straight tubules is physiologically substantial.	Water	230-235	aquaporin 7	Mus musculus	86-90
31784665-9	2019	Interestingly, only two of them (hsa-miR-302a and hsa-miR-122) were significantly under-expressed in H2O2-induced sEVs.	Water	101-105	microRNA 122	Homo sapiens	50-61
15998844-5	2005	Although AQP7 solo-knockout mice did not exhibit a urinary concentrating defect, AQP1/AQP7 double-knockout mice had a reduction in urinary concentrating ability compared with AQP1 solo-knockout mice, suggesting that the amount of water reabsorbed through AQP7 in the proximal straight tubules is physiologically substantial.	Water	230-235	aquaporin 7	Mus musculus	86-90
31124831-8	2019	The annual effective doses calculated from radionuclides in the water are 0.11, 0.09, 0.09, and 0.11 mSv for borehole, stream, tap, and well, respectively.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	127-130
16293109-2	2005	Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts.	Water	79-84	aquaporin 2	Homo sapiens	15-19
30646797-1	2019	Objective: Tap water iontophoresis as a treatment for focal hyperhidrosis is given as an initial series of treatments in hospital, followed by home maintenance treatments.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
30646797-12	2019	Conclusion: In conclusion, tap water iontophoresis can result in a significant improvement in perceived severity of hyperhidrosis and quality of life.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
31585994-4	2019	The goal of this study was to identify the extent to which the boat microbial community is shaped by the microbial community in the port water where the boat spends most of its time.	Water	137-142	ataxin 1 like	Homo sapiens	63-67
31585994-4	2019	The goal of this study was to identify the extent to which the boat microbial community is shaped by the microbial community in the port water where the boat spends most of its time.	Water	137-142	ataxin 1 like	Homo sapiens	153-157
31585994-15	2019	This suggests that the water influences the bacterial community of a boat and that microorganisms living on a boat could be moved from place to place when the boat travels.	Water	23-28	ataxin 1 like	Homo sapiens	69-73
31585994-15	2019	This suggests that the water influences the bacterial community of a boat and that microorganisms living on a boat could be moved from place to place when the boat travels.	Water	23-28	ataxin 1 like	Homo sapiens	110-114
31585994-15	2019	This suggests that the water influences the bacterial community of a boat and that microorganisms living on a boat could be moved from place to place when the boat travels.	Water	23-28	ataxin 1 like	Homo sapiens	110-114
16150901-1	2005	In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water transport by vasopressin.	Water	78-83	aquaporin 2	Homo sapiens	14-25
31645471-7	2019	Seropositivity (aquaporin-4 water channel-immunoglobulin G [IgG] or myelin oligodendrocyte glycoprotein-IgG) was found in 20 of 42 (48%) patients.	Water	28-33	aquaporin 4	Homo sapiens	16-27
16150901-1	2005	In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water transport by vasopressin.	Water	78-83	aquaporin 2	Homo sapiens	27-31
16150901-2	2005	Short-term control of water permeability occurs via vesicular trafficking of AQP2 and long-term control through changes in the abundance of AQP2 and AQP3 water channels.	Water	22-27	aquaporin 2	Homo sapiens	77-81
16400790-4	2005	V2 is localized to renal tissue and its activation leads to upregulation of aquaporin-2 in the collecting duct allowing the reabsorption of large volumes of water.	Water	157-162	aquaporin 2	Homo sapiens	76-87
30377818-6	2019	The glial-lymphatic system, responsible for convective solute clearance driven by active fluid transport through aquaporin-4 water channels, may be implicated in brain amyloid deposition.	Water	125-130	aquaporin 4	Homo sapiens	113-124
16287990-1	2005	The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues.	Water	149-154	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	18-23
31158313-4	2019	Tap water arsenic concentrations and risk perception data were collected from two Saskatchewan communities.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
31158313-8	2019	The probability of consuming tap water perceived as safe (92%) or not safe (0%) suggested that households in RM184 were unlikely to drink water perceived as not safe.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
31158313-9	2019	The probability of drinking tap water perceived as safe (77%) or as not safe (11%) suggested households in BOFN contradicted their perception and consumed water perceived as unsafe.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
16287990-1	2005	The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues.	Water	149-154	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	25-31
16287990-1	2005	The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues.	Water	149-154	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	33-38
16163767-4	2005	Similarly, the reaction of PMAT (15) with Mn(ClO4)2.6H2O or M(BF4)2.6 H2O (M=Fe, Co, Ni, Zn) in a ligand-to-metal molar ratio of 1:1 has afforded a series of complexes with the general formula [M(II) (2)(PMAT)2]X4.	Water	53-56	solute carrier family 29 member 4	Homo sapiens	27-31
31377524-7	2019	Soluble anions and cations in tap water were also present in the aerosols emitted from humidifiers.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
15956775-12	2005	These results suggest that the increased protein abundance of ENaC subunits as well as the increased apical targeting of AQP2 may contribute to renal sodium and water retention observed during the development of hypertension in SHR.	Water	161-166	aquaporin 2	Rattus norvegicus	121-125
31382062-12	2019	In addition, DDR1 silencing attenuated the effects of the miR-199a-5p inhibitor on neurologic function, infarct volume, brain water content, and proinflammatory cytokine expressions after middle cerebral artery occlusion in rats.	Water	126-131	discoidin domain receptor tyrosine kinase 1	Rattus norvegicus	13-17
31673799-5	2019	The POx mimic was used for determination of L-lactic acid via detection of H2O2 that is produced by the enzyme lactate oxidase (LOx).	Water	75-79	lysyl oxidase	Homo sapiens	111-126
16215756-12	2005	Linear calibration plots were obtained for Cd2+ in acidified tap water at concentrations ranging from 2 x 10(-8) to 1 x 10(-7) mol L(-1) and from 1 x 10(-7) to 1 x 10(-6) mol L(-1) with relative standard deviations of 5% (n = 15) at the 1 x 10(-7) mol L(-1) level.	Water	65-70	CD2 molecule	Homo sapiens	43-46
31673799-5	2019	The POx mimic was used for determination of L-lactic acid via detection of H2O2 that is produced by the enzyme lactate oxidase (LOx).	Water	75-79	lysyl oxidase	Homo sapiens	128-131
16216844-6	2005	Interestingly, 2 h after the addition of 100 mM NaCl, when maize regained the osmotic potential allowing water uptake, three highly expressed, specific isoforms ZmPIP1;1, ZmPIP1;5, and ZmPIP2;4 were transiently induced.	Water	105-110	aquaporin PIP1-1	Zea mays	161-169
31539242-5	2019	Extensive molecular dynamic simulations unveiled much higher binding affinities of the water-derived NMR structure compared to the original YM conformation of pdb 3ah8 .	Water	87-92	sequestosome 1	Homo sapiens	159-167
16596446-9	2005	RT-PCR and immunocytochemistry demonstrated predominant expression of AQP3 water channel in this cell line.	Water	75-80	aquaporin 3 (Gill blood group)	Homo sapiens	70-74
31441298-8	2019	In the following test of real spiked samples of tap water and lake water, the recovery ratios of formaldehyde with the concentrations from 0.010 to 0.045 mM are tested to be between 95 and 100% by both measuring the variance in short circuit current and analyzing the color change of the cathode digitally.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
16596446-11	2005	Thus, it is concluded that AQP3 water channels serve as an essential pathway for volume-regulatory water transport in, human epithelial cells.	Water	32-37	aquaporin 3 (Gill blood group)	Homo sapiens	27-31
31681726-1	2019	In this study, a series of novel 1,5-di(nitramino)tetrazole (DNAT)-based bimetallic energetic coordination polymers, MK2(DNAT)2 4H2O [M = Fe, Cu, Ni, Co, and Zn], were designed and synthesized in a simple and convenient self-assembly synthetic process.	Water	128-132	MAPK activated protein kinase 2	Homo sapiens	117-120
15919094-4	2005	The myosin head contains a large number of strongly restrained water molecules, which makes the ATP-driven electric dipole motor possible.	Water	63-68	myosin heavy chain 14	Homo sapiens	4-10
31604971-4	2019	For these studies, male and female mice were exposed to Cd-containing drinking water for >2 weeks before breeding.	Water	79-84	cathepsin D	Mus musculus	56-58
31604971-5	2019	Pregnant mice and dams with offspring were exposed to Cd-containing drinking water.	Water	77-82	cathepsin D	Mus musculus	54-56
15919094-5	2005	The strongly restrained water molecules can store the chemical energy released by ATP binding and hydrolysis processes in the electric form due to their myosin structure fixed electric dipole moments (p(i)).	Water	24-29	myosin heavy chain 14	Homo sapiens	153-159
15919094-9	2005	Using the previously published experimental data for the electric dipole of ATP (p(0) congruent with 230 debye) and for the amount of strongly restrained water molecules (N congruent with 720) in the myosin subfragment (S1), we show that the Gibbs free energy changes of the ATP binding and hydrolysis reaction steps can be converted into the form of electric energy.	Water	154-159	myosin heavy chain 14	Homo sapiens	200-206
15914774-8	2005	Moreover, 1 h following the oral water load, HT rats demonstrated a significant increase in the membrane-to-vesicle fraction of AQP2 by Western blot analysis.	Water	33-38	aquaporin 2	Rattus norvegicus	128-132
31532667-10	2019	Practical application of this ratiometric fluorescent probe to detect OPs was further verified in tap water and food samples with satisfying results that were highly consisted with the results obtained by GC-MS.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
31503468-1	2019	The detection of hypochlorite (ClO-) content in tap water is extremely important because excess amounts of hypochlorite can convert into highly toxic species and inadequate amounts of hypochlorite cannot fully kill bacteria and viruses.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
15942941-5	2005	Here we report the cloning and sequencing of Adrb2 clones from either dissected lung tumors from NNK-injected animals or whole-lung tissue from water-injected controls.	Water	144-149	beta-2 adrenergic receptor	Mesocricetus auratus	45-50
16383351-1	2005	We simulate TIP3P water using a constrained Monte Carlo algorithm to generate electrostatic interactions eliminating the need to sum over long-ranged Coulomb interactions.	Water	18-23	suppressor of cytokine signaling 1	Homo sapiens	12-16
31254804-5	2019	When validated for practical and quantitative detection of tap water and milk samples, both sensing methods performed well with detection limits of &lt;260 nM and measurement times of &lt;40 min.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
16305339-7	2005	One group of these mice was given LF in drinking water (0.5% solution).	Water	49-54	lactotransferrin	Mus musculus	34-36
31283422-5	2019	The average Pb and Cd intakes from food and drinking (tap) water ranged for children from 0.90 to 1.021 microg/kg bw/day and 4.65 to 5.65 microg/kg bw/week, respectively, and for adults, including adolescents, from 0.40 to 0.53 microg/kg bw/day and 1.98 to 2.82 microg/kg bw/week, respectively.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	54-57
31424532-12	2019	Women living in areas with fluoridated tap water (n = 141) compared with nonfluoridated water (n = 228) had significantly higher mean (SD) MUFSG concentrations (0.69 [0.42] mg/L vs 0.40 [0.27] mg/L; P = .001; to convert to millimoles per liter, multiply by 0.05263) and fluoride intake levels (0.93 [0.43] vs 0.30 [0.26] mg of fluoride per day; P = .001).	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
31310912-5	2019	It also inhibited Keap1, activated Nrf2 antioxidant pathway, resulting in the suppression of oxidative stress, evidenced by reducing hydrogen peroxide (H2O2), malondialdehyde (MDA) and hydroxy radical (OH ) levels, and increasing glutathione (GSH)/oxidized glutathione (GSSG) ratio as well as superoxidase dismutase (SOD) and catalase (CAT) activity in the liver of fructose-fed rats.	Water	185-200	Kelch-like ECH-associated protein 1	Rattus norvegicus	18-23
32684655-2	2019	Herein, we describe the Cu(OTf)2-catalyzed BKR of ketones under mild reaction conditions using hydroxylamine-O-sulfonic acid (HOSA), a commercial water soluble aminating agent.	Water	146-151	POU class 2 homeobox 2	Homo sapiens	24-32
31562333-3	2019	While H2O2 exposure substantially decreases cell proliferation and increases p53, p21, p16, and p19 in cells from mice and rats, cells from spiny mice and rabbits are highly resistant to H2O2.	Water	6-10	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	82-85
31158625-11	2019	These findings indicate that drinking water is the main source of AsF coexposure and suggest that F exposure decreases As methylation capacity.	Water	38-43	arylsulfatase F	Homo sapiens	66-69
31361900-3	2019	For the first time, the unusual geometry of several G:G mismatches including syn-syn, water mediated anti-syn and syn-syn-like conformations can be simultaneously observed in the crystal structure.	Water	86-91	synemin	Homo sapiens	77-80
31430153-1	2019	The vibrational spectrum of the protonated water trimer, H+(H2O)3, is surprisingly complex, with many strong features in the expected region of the fundamentals associated with two H-bonded OH groups on the H3O+ core ion.	Water	43-48	H3 clustered histone 15	Homo sapiens	207-210
31430153-1	2019	The vibrational spectrum of the protonated water trimer, H+(H2O)3, is surprisingly complex, with many strong features in the expected region of the fundamentals associated with two H-bonded OH groups on the H3O+ core ion.	Water	60-64	H3 clustered histone 15	Homo sapiens	207-210
31641423-9	2019	Protein levels and SGK1 activation were significantly stimulated by H2O2 exposure.	Water	68-72	serum/glucocorticoid regulated kinase 1	Homo sapiens	19-23
31641423-10	2019	HK-2 cells with SGK1 inhibition were much more sensitive to H2O2-induced oxidative stress injury than control group cells, as they exhibited increased apoptotic cell death and mitochondrial dysfunction involving the deterioration of cellular ATP production, ROS accumulation, mitochondrial membrane potential reduction, and release of Cytochrome C into the cytoplasm.	Water	60-64	serum/glucocorticoid regulated kinase 1	Homo sapiens	16-20
31641423-13	2019	H2O2 leads to SGK1 overexpression in HK-2 cells, which protects human renal tubule cells from oxidative stress injury by improving mitochondrial function and inactivating GSK3beta.	Water	0-4	serum/glucocorticoid regulated kinase 1	Homo sapiens	14-18
31428911-6	2019	The study provides a detailed analysis of the conformational properties and non-covalent interactions observed in the crystal structures of two polymorphs of the pentapeptide monohydrate, Boc-Aib-(S)Pgn-Leu-Phe-Val-OMe (C38H63N5O8 H2O) and the isomeric pentapeptide, Boc-Aib-gamma4(R)Leu-Leu-Phe-Val-OMe (C38H63N5O8), obtained from single crystal X-ray diffraction experiments.	Water	231-234	ANIB1	Homo sapiens	192-195
30693533-1	2019	The alternative oxidase (AOX) is a ubiquitous terminal oxidase of plants and many fungi, catalyzing the four-electron reduction of oxygen to water alongside the cytochrome-based electron transfer chain.	Water	141-146	acyl-CoA oxidase 1	Homo sapiens	4-23
30693533-1	2019	The alternative oxidase (AOX) is a ubiquitous terminal oxidase of plants and many fungi, catalyzing the four-electron reduction of oxygen to water alongside the cytochrome-based electron transfer chain.	Water	141-146	acyl-CoA oxidase 1	Homo sapiens	25-28
30740619-0	2019	Water-Soluble Arginyl-Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-kappaB and JNK MAPK Signaling in Adult Mice Challenged by LPS.	Water	0-5	mitogen-activated protein kinase 8	Mus musculus	150-153
31171189-0	2019	A fluorescein-based AND-logic FPSi probe for the simultaneous detection of Hg2+ and F. In this study, we have designed and synthesized a novel "AND" logic based fluorescence probe,1-(3",6"-bis((tert-butyldiphenylsilyl)oxy)-3-oxospiro (isoindoline-1,9"-xanthen)-2-yl)-3-phenylthiourea (FPSi), for the rapid (3 min) simultaneous detection of F- and Hg2+ in DMSO/H2O solution (7:3, v/v).	Water	360-363	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	75-78
31424469-0	2019	Bonding state synergy of the NiF2/Ni2P hybrid with the co-existence of covalent and ionic bonds and the application of this hybrid as a robust catalyst for the energy-relevant electrooxidation of water and urea.	Water	196-201	zinc finger protein 335	Homo sapiens	29-33
31424469-2	2019	Herein, the NiF2/Ni2P hybrid catalyst, in which covalent and ionic bonds co-existed, was found to be a very active catalyst for these electrochemical reactions occuring during the electrolysis of water.	Water	196-201	zinc finger protein 335	Homo sapiens	12-16
31424469-4	2019	As a bifunctional catalyst for the electrooxidation of water and urea, the NiF2/Ni2P hybrid structure demonstrated higher catalytic activity, kinetics and stability in the catalytic reaction than the individual components NiF2 and Ni2P under the same conditions.	Water	55-60	zinc finger protein 335	Homo sapiens	75-79
31424469-7	2019	Using a commercial Pt/C catalyst as a cathode, the cell potential for urea-assisted water electrolysis could be reduced to 1.5 V to obtain the current density of nearly 40 mA cm-2 in a two-electrode system (Pt/C  NiF2/Ni2P), about 300 mV less than that required for water electrolysis in the general alkaline electrolyte.	Water	84-89	zinc finger protein 335	Homo sapiens	213-217
31365240-6	2019	The -NAc-CH2- bridged derivative is soluble in water, and all photophysical properties (conversion rates, quantum yields, and thermal half-lives) are largely retained.	Water	47-52	X-linked Kx blood group	Homo sapiens	5-8
33795948-2	2021	Since it was first described, new information about the pathophysiology gained momentum with the discovery of an antibody against Aquaporin-4, a water channel protein that is predominantly found in the astrocytes.	Water	145-150	aquaporin 4	Homo sapiens	130-141
31498301-6	2019	CNO was administered either by using repetitive (daily) eye-drops, or chronically through the animal"s drinking water.	Water	112-117	biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino	Mus musculus	0-3
31426396-0	2019	Automatic Extraction of Water and Shadow from SAR Images Based on a Multi-Resolution Dense Encoder and Decoder Network.	Water	24-29	sarcosine dehydrogenase	Homo sapiens	46-49
31426396-1	2019	The water and shadow areas in SAR images contain rich information for various applications, which cannot be extracted automatically and precisely at present.	Water	4-9	sarcosine dehydrogenase	Homo sapiens	30-33
24687884-3	2019	In solar water splitting, the hollow spheres exhibit remarkably enhanced photocatalytic performance that is 1.4 times of P25.	Water	9-14	tubulin polymerization promoting protein	Homo sapiens	121-124
30684147-6	2019	Furthermore, real-time PCR revealed that the aged SMG exhibited accelerated cell aging, increased levels of the inflammatory cytokine interleukin-6, and decreased mRNA levels of the water channel protein aquaporin-5 (AQP5).	Water	182-187	aquaporin 5	Mus musculus	204-215
30684147-6	2019	Furthermore, real-time PCR revealed that the aged SMG exhibited accelerated cell aging, increased levels of the inflammatory cytokine interleukin-6, and decreased mRNA levels of the water channel protein aquaporin-5 (AQP5).	Water	182-187	aquaporin 5	Mus musculus	217-221
31127425-1	2019	Misbeliefs in spa water disinfection.	Water	18-23	surfactant protein A2	Homo sapiens	14-17
31477627-5	2019	The concentration of Cl&lt;sup&gt;-&lt;/sup&gt; was 0.7mg/L in tap water and 0.1mg/L in RO water, while the concentration of SiO&lt;sub&gt;4&lt;/sub&gt;&lt;sup&gt;4-&lt;/sup&gt; was 0.3mg/L in both the tap and RO water.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
31771591-9	2019	Knockout of SPOP or expression of prostate cancer-associated SPOP mutants conferred resistance to death caused by SG inducers (e.g. docetaxel, sodium arsenite and H2O2) in prostate cancer cells.	Water	163-167	speckle type BTB/POZ protein	Homo sapiens	12-16
31771591-9	2019	Knockout of SPOP or expression of prostate cancer-associated SPOP mutants conferred resistance to death caused by SG inducers (e.g. docetaxel, sodium arsenite and H2O2) in prostate cancer cells.	Water	163-167	speckle type BTB/POZ protein	Homo sapiens	61-65
31461688-4	2019	Our high resolution co-crystal structures of 47/BRD2 BD1 and BD2 showed that the triazole group of 47, water molecules, H433 and N429 in BRD2 BD2 established a water-bridged H-bonding network, which is responsible for the observed selectivities.	Water	103-108	bromodomain containing 2	Homo sapiens	48-52
31461688-4	2019	Our high resolution co-crystal structures of 47/BRD2 BD1 and BD2 showed that the triazole group of 47, water molecules, H433 and N429 in BRD2 BD2 established a water-bridged H-bonding network, which is responsible for the observed selectivities.	Water	103-108	bromodomain containing 2	Homo sapiens	137-141
31461688-4	2019	Our high resolution co-crystal structures of 47/BRD2 BD1 and BD2 showed that the triazole group of 47, water molecules, H433 and N429 in BRD2 BD2 established a water-bridged H-bonding network, which is responsible for the observed selectivities.	Water	160-165	bromodomain containing 2	Homo sapiens	48-52
31461688-4	2019	Our high resolution co-crystal structures of 47/BRD2 BD1 and BD2 showed that the triazole group of 47, water molecules, H433 and N429 in BRD2 BD2 established a water-bridged H-bonding network, which is responsible for the observed selectivities.	Water	160-165	bromodomain containing 2	Homo sapiens	137-141
31827676-8	2019	Our results showed that decreased methylation levels of ALP and RUNX2 were induced by H2O2 treatment in hMSCs cultivated in the 3D scaffolds.	Water	86-90	ATHS	Homo sapiens	56-59
31827676-10	2019	The hypomethylation of ALP and RUNX2 induced by H2O2 treatment was abolished by Dnmt3a overexpression.	Water	48-52	ATHS	Homo sapiens	23-26
31325851-4	2019	The implementation of water-saving technology in 2000 effectively improved the utilization efficiency of water resources and accelerated the formation of artificial oases; these expanded by 3873.3 km2 while natural oasis area was reduced by 3485.0 km2.	Water	22-27	cAMP responsive element binding protein 3 like 1	Homo sapiens	215-220
31472335-3	2019	This study investigated the bacterial growth through a POU water dispenser fed with chlorinated tap water; specifically, the heterotrophic plate count increased from 0.01 to 20.01 x 103 of colony-forming units per ml.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	96-99
31472335-3	2019	This study investigated the bacterial growth through a POU water dispenser fed with chlorinated tap water; specifically, the heterotrophic plate count increased from 0.01 to 20.01 x 103 of colony-forming units per ml.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
31814699-8	2019	We treated SRA01/04 cells with H2O2 to mimic oxidative stress and induce cell apoptosis, which was analyzed by flow cytometry and TdT-mediated dUTP Nick-End Labeling (TUNEL) assay.	Water	31-35	DNA nucleotidylexotransferase	Homo sapiens	130-133
31353339-0	2019	A highly selective and ultrasensitive fluorescent probe for monitoring Hg2+ and its applications in real water samples.	Water	105-110	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	71-74
31701355-4	2019	When lactate oxidase was immobilized on the modified electrode, the electrode responded to lactate via the H2O2 generated in the enzymatic reaction.	Water	107-111	lysyl oxidase	Homo sapiens	5-20
31445443-8	2019	The significantly downregulation of COL1A1 and the variation of rheumatoid arthritis pathway suggested that surface water potentially inhibited osteogenic differentiation of hBMSCs.	Water	116-121	collagen type I alpha 1 chain	Homo sapiens	36-42
31362045-4	2019	Glymphatic system claims the direct bulk flow transport of small size water-soluble waste metabolites into to the perivenous space by aquaporin-4 water channels of the astrocyte end-feet, but it did not address the diffusive clearance of large size waste metabolites.	Water	70-75	aquaporin 4	Homo sapiens	134-145
31362045-4	2019	Glymphatic system claims the direct bulk flow transport of small size water-soluble waste metabolites into to the perivenous space by aquaporin-4 water channels of the astrocyte end-feet, but it did not address the diffusive clearance of large size waste metabolites.	Water	146-151	aquaporin 4	Homo sapiens	134-145
30513364-2	2019	The majority of patients with NMOSD are seropositive for autoantibodies against the astrocyte water channel aquaporin-4 (AQP4).	Water	94-99	aquaporin 4	Homo sapiens	121-125
31327289-1	2019	Objective: To design and characterize aerosol microparticles (MP) to provide sustained release of the water-soluble compound sulforhodamine B (SRB) and achieve effective aerosol dispersion.	Water	102-107	chaperonin containing TCP1 subunit 4	Homo sapiens	125-141
31671709-0	2019	Comparison of Culture- and Quantitative PCR-Based Indicators of Antibiotic Resistance in Wastewater, Recycled Water, and Tap Water.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
31671815-2	2019	Transient receptor potential melastatin 2 (TRPM2) channel is a Ca2+ permeable cation channel that can be activated by H2O2 and plays an important role in cellular functions.	Water	118-122	transient receptor potential cation channel subfamily M member 2	Homo sapiens	0-41
31671815-2	2019	Transient receptor potential melastatin 2 (TRPM2) channel is a Ca2+ permeable cation channel that can be activated by H2O2 and plays an important role in cellular functions.	Water	118-122	transient receptor potential cation channel subfamily M member 2	Homo sapiens	43-48
31401269-9	2019	This work proves that the MCS/ZnO@Alg gel beads are an ideal candidate for addressing the grievous environmental threats caused by water pollution.	Water	131-136	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	26-29
31404605-4	2019	XRD patterns implied that the crystallinity of CSDA greatly declined due to the introduction of alkyl moieties, favorable for improving water solubility.	Water	136-141	Y box protein 3	Mus musculus	47-51
31528972-10	2019	We found that HO3 is higher in our xanthan gum/FeCl2 particles than for water and increases when RH decreased from about 80% to dry conditions.	Water	72-77	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	14-17
31100203-7	2019	As the mechanism of indirect effect, H2 in drinking water induces ghrelin production and release from the stomach via beta1-adrenergic receptor stimulation.	Water	52-57	adrenergic receptor, beta 1	Mus musculus	118-143
31018907-13	2019	Several patients admitted to exposing their CL to unsterile water either via swimming, showering or tap water.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
31286686-4	2019	The average dmdA:recA gene ratio over the sampling period was 0.40 +- 0.24 in marine snow and 0.48 +- 0.21 in the ambient water.	Water	122-127	RAD51 recombinase	Homo sapiens	17-21
31421451-9	2019	According to the toxicological information about PFAS that is so far available, the current health risks for the regular consumers of municipal/tap water do not seem to be of concern according to the levels considered as acceptable for various regulatory institutions.	Water	148-153	nuclear RNA export factor 1	Homo sapiens	144-147
31565882-1	2019	BACKGROUND: Striatin and caveolin-1 (cav-1) are scaffolding/regulating proteins that are associated with salt-sensitive high blood pressure and promote renal sodium and water reabsorption, respectively.	Water	169-174	striatin	Rattus norvegicus	12-20
31209505-7	2019	The CD4+/CD8+ and Th17/Treg ratios in EAU rats were apparently higher than those in normal control individuals.	Water	38-41	Cd4 molecule	Rattus norvegicus	4-7
31517003-0	2019	Behavioral therapy ceased cold water immersion dependence in a patient with familial erythromelalgia caused by SCN9A mutation.	Water	31-36	sodium voltage-gated channel alpha subunit 9	Homo sapiens	111-116
31334514-5	2019	The overall water splitting made up of the two-electrode system with Fe-MoS2/Ni3S2/NF-2 as both the anode and the cathode required a voltage of only 1.61 V to drive a current density of 10 mA cm-2 along with an outstanding long-term stability of 20 h, displaying its great potential for application in water splitting.	Water	12-17	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	83-87
31036214-5	2019	The probe was quenched by Hg2+ and Ag+ with 1:1 binding ratios in MeCN/H2O (4/1, v/v) mixed solution with binding constants of 3.76 x 104 L mol-1 and 2.47 x 104 L mol-1, respectively.	Water	71-74	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	26-29
16134088-8	2005	Among the new synthesized copolymers (P1-P23), seven diblock or triblock samples (P3, P6, P7, P11, P12, P19, and P21) with higher hydrophilic building block populations were revealed to be water soluble under ambient temperature.	Water	189-194	interleukin 23 subunit alpha	Homo sapiens	104-107
31082641-4	2019	In surface water, the attack of BP3 by hydroxyl radicals (HO ) or carbonate radicals (CO3 -) in UV/H2O2 can generate BP8, which was responsible for the relatively high degradation rate of BP3.	Water	11-16	BP8	Homo sapiens	117-120
31413203-9	2019	Spontaneous DNA strand exchange catalyzed by poly(ethylene glycol) makes us propose that hydrophobic residues in the L2 loop of recombination enzymes RecA and Rad51 may assist gene recombination via modulation of water activity near the DNA helix by hydrophobic interactions, in the manner described here.	Water	213-218	RAD51 recombinase	Homo sapiens	150-154
31413203-9	2019	Spontaneous DNA strand exchange catalyzed by poly(ethylene glycol) makes us propose that hydrophobic residues in the L2 loop of recombination enzymes RecA and Rad51 may assist gene recombination via modulation of water activity near the DNA helix by hydrophobic interactions, in the manner described here.	Water	213-218	RAD51 recombinase	Homo sapiens	159-164
31282659-7	2019	In the MDM2 case, the higher affinity of MIP is ascribed to a larger gain of translational, configurational entropy of water upon binding.	Water	119-124	MDM2 proto-oncogene	Homo sapiens	7-11
16144398-1	2005	Trialkylboranes (BMe3, BEt3, and BBu3) have been shown to mediate reductive deoxygenation reactions of O-alkyl-S-methyl dithiocarbonates (methyl xanthates) in which water or deuterium oxide functions as the source of hydrogen or deuterium.	Water	165-170	trafficking protein particle complex subunit 3	Homo sapiens	23-27
31237420-1	2019	In this work, the properties of "water-in-PIL" (PIL=protic ionic liquid) electrolytes are reported based on 1-butylpyrrolidinium bis(trifluoromethanesulfonyl)imide (PyrH4 TFSI).	Water	33-38	serpin family A member 2 (gene/pseudogene)	Homo sapiens	42-45
31177962-3	2019	Drag reduction (e.g. for ship hulls) requires the presence of a rather thick and persistent air layer under water.	Water	108-113	inositol polyphosphate-5-phosphatase D	Homo sapiens	25-29
16243276-1	2005	Monolinoleoyl trehalose, maltose and cellobiose were synthesized by Candida antarctica lipase-catalyzed condensation in an organic solvent with a low water content.	Water	150-155	PAN0_003d1715	Moesziomyces antarcticus	87-93
31276397-8	2019	Because Sr2+/Ca2+ substitution alters this D-O-D bending mode but the D1-S169A mutation does not, we conclude that the water-derived oxygen that relocates and becomes O6/Ox derives from the Ca2+-bound W3.	Water	119-124	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	167-172
31237420-1	2019	In this work, the properties of "water-in-PIL" (PIL=protic ionic liquid) electrolytes are reported based on 1-butylpyrrolidinium bis(trifluoromethanesulfonyl)imide (PyrH4 TFSI).	Water	33-38	serpin family A member 2 (gene/pseudogene)	Homo sapiens	48-51
31237420-5	2019	However, at the same time, water reduces the operative voltage of EDLCs containing this PIL as the electrolyte and, furthermore, it has a strong impact on the inactive components of these systems.	Water	27-32	serpin family A member 2 (gene/pseudogene)	Homo sapiens	88-91
31340122-3	2019	The results showed that the higher the oil/water interfacial tension, the greater is the amount of CNFs adsorbed at the oil/water interface, making the CNF-adsorbed oil-in-water emulsions thermodynamically more stable.	Water	43-48	NPHS1 adhesion molecule, nephrin	Homo sapiens	99-102
31340122-3	2019	The results showed that the higher the oil/water interfacial tension, the greater is the amount of CNFs adsorbed at the oil/water interface, making the CNF-adsorbed oil-in-water emulsions thermodynamically more stable.	Water	124-129	NPHS1 adhesion molecule, nephrin	Homo sapiens	99-102
31340122-3	2019	The results showed that the higher the oil/water interfacial tension, the greater is the amount of CNFs adsorbed at the oil/water interface, making the CNF-adsorbed oil-in-water emulsions thermodynamically more stable.	Water	124-129	NPHS1 adhesion molecule, nephrin	Homo sapiens	99-102
31340122-5	2019	The dispersion stability of the oil droplets was dominated by the CNF concentration in the water phase.	Water	91-96	NPHS1 adhesion molecule, nephrin	Homo sapiens	66-69
31336566-8	2019	CaO grains were bonded by the formed tricalcium aluminate (C3A) and the apparent porosity of the sample was reduced, reducing the contact area of CaO with water vapor.	Water	155-160	complement C3	Homo sapiens	59-62
15878601-8	2005	In non-urbanized areas concentrations in water varied from 0.22 to 1.20 (microM) for P-inorg and 4.43 to 5.56 (microM) for P-org, and in sediments from 45.91 to 652.26 (microM g(-1)) for P-tot and 0.00 to 8.61 (microM g(-1)) for P-poly.	Water	41-46	solute carrier family 10 member 4	Homo sapiens	85-98
31342020-0	2019	Dual-entropy-driven catalytic amplification reaction for ultra-sensitive and visible detection of Hg2+ in water based on thymine-Hg2+-thymine coordination chemistry.	Water	106-111	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	98-101
31342020-0	2019	Dual-entropy-driven catalytic amplification reaction for ultra-sensitive and visible detection of Hg2+ in water based on thymine-Hg2+-thymine coordination chemistry.	Water	106-111	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	129-132
31030157-7	2019	At least three NNIs were detected in all tap water samples with the highest sum concentration of NNIs observed in July (median: 96.2ng/L, range: 16.7-138ng/L) among the studied months (median: 15.4, range: 2.59-138ng/L).	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
16853033-0	2005	Interaction of CsF with multilayered water.	Water	37-42	colony stimulating factor 2	Homo sapiens	15-18
31030157-9	2019	The concentrations observed in tap water are elevated in China relative to previous studies that were conducted in the USA and in Canada.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
31129217-1	2019	In this study, the purified water-soluble polysaccharide (ALP-1) from Arctium lappa was used to intervene lipopolysaccharide-induced RAW264.7 macrophage and systemic inflammatory mice.	Water	28-33	apolipoprotein A-I	Mus musculus	58-63
16853033-1	2005	The interaction of CsF with multilayered water has been investigated with metastable impact electron spectroscopy (MIES) and ultraviolet photoelectron spectroscopy with HeI (UPS(HeI)).	Water	41-46	colony stimulating factor 2	Homo sapiens	19-22
31330936-0	2019	Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p-Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver.	Water	41-46	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	80-94
31343168-3	2019	PRA-1 had a rod-like conformation, while PRA-1p exhibited a monodisperse and homogeneous spherical conformation with a diameter ranging from 0.3 to 2.0 mum in water.	Water	159-164	Rab acceptor 1 (prenylated)	Mus musculus	41-47
16853033-3	2005	We have prepared CsF-H2O interfaces, namely, CsF layers on thin films of multilayered water and vice versa; they were annealed between 80 and about 280 K. Up to about 100 K, a closed CsF layer can be deposited on H2O and vice versa; no interpenetration of the two components H2O and CsF could be observed.	Water	21-24	colony stimulating factor 2	Homo sapiens	17-20
31330936-0	2019	Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p-Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver.	Water	41-46	ATP binding cassette subfamily C member 2	Rattus norvegicus	100-141
16853033-3	2005	We have prepared CsF-H2O interfaces, namely, CsF layers on thin films of multilayered water and vice versa; they were annealed between 80 and about 280 K. Up to about 100 K, a closed CsF layer can be deposited on H2O and vice versa; no interpenetration of the two components H2O and CsF could be observed.	Water	21-24	colony stimulating factor 2	Homo sapiens	45-48
16853033-3	2005	We have prepared CsF-H2O interfaces, namely, CsF layers on thin films of multilayered water and vice versa; they were annealed between 80 and about 280 K. Up to about 100 K, a closed CsF layer can be deposited on H2O and vice versa; no interpenetration of the two components H2O and CsF could be observed.	Water	21-24	colony stimulating factor 2	Homo sapiens	45-48
31412038-7	2019	Mice avoided water sources surrounded by both volatile TRPV1 (cyclohexanone) and TRPA1 (allyl isothiocyanate) irritants and the aversion to cyclohexanone was mitigated when combined with a pure odorant (rose fragrance, phenylethyl alcohol, PEA).	Water	13-18	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	81-86
16853033-3	2005	We have prepared CsF-H2O interfaces, namely, CsF layers on thin films of multilayered water and vice versa; they were annealed between 80 and about 280 K. Up to about 100 K, a closed CsF layer can be deposited on H2O and vice versa; no interpenetration of the two components H2O and CsF could be observed.	Water	21-24	colony stimulating factor 2	Homo sapiens	45-48
30880180-0	2019	A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway.	Water	16-21	heme oxygenase 1	Rattus norvegicus	134-138
16853033-3	2005	We have prepared CsF-H2O interfaces, namely, CsF layers on thin films of multilayered water and vice versa; they were annealed between 80 and about 280 K. Up to about 100 K, a closed CsF layer can be deposited on H2O and vice versa; no interpenetration of the two components H2O and CsF could be observed.	Water	86-91	colony stimulating factor 2	Homo sapiens	17-20
16853033-3	2005	We have prepared CsF-H2O interfaces, namely, CsF layers on thin films of multilayered water and vice versa; they were annealed between 80 and about 280 K. Up to about 100 K, a closed CsF layer can be deposited on H2O and vice versa; no interpenetration of the two components H2O and CsF could be observed.	Water	213-216	colony stimulating factor 2	Homo sapiens	17-20
16853033-3	2005	We have prepared CsF-H2O interfaces, namely, CsF layers on thin films of multilayered water and vice versa; they were annealed between 80 and about 280 K. Up to about 100 K, a closed CsF layer can be deposited on H2O and vice versa; no interpenetration of the two components H2O and CsF could be observed.	Water	213-216	colony stimulating factor 2	Homo sapiens	17-20
31006718-8	2019	Finally, the recovery does not exceed 10% of the original value for the detection of Hg2+ ion in tap and bottled water.	Water	113-118	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	85-88
30930351-2	2019	Special care was taken for the validation of the proposed ID-ICPMS method using CRM 7203-a, a certified reference material for elemental analysis of tap water.	Water	153-158	nuclear RNA export factor 1	Homo sapiens	149-152
16853033-4	2005	Above 110 K, CsF (H2O) layers deposited on thin H2O (CsF) films (stoichiometry CsF.1.5H2O) gradually transform into a mixed layer containing F, Cs, and H2O species.	Water	18-21	colony stimulating factor 2	Homo sapiens	13-16
16853033-4	2005	Above 110 K, CsF (H2O) layers deposited on thin H2O (CsF) films (stoichiometry CsF.1.5H2O) gradually transform into a mixed layer containing F, Cs, and H2O species.	Water	18-21	colony stimulating factor 2	Homo sapiens	53-56
31283059-2	2019	Free from natural environmental disturbances, two different anti-anti and syn-anti planar forms and the corresponding water clusters have been revealed in a supersonic expansion.	Water	118-123	synemin	Homo sapiens	74-77
16853033-4	2005	Above 110 K, CsF (H2O) layers deposited on thin H2O (CsF) films (stoichiometry CsF.1.5H2O) gradually transform into a mixed layer containing F, Cs, and H2O species.	Water	18-21	colony stimulating factor 2	Homo sapiens	53-56
16853033-4	2005	Above 110 K, CsF (H2O) layers deposited on thin H2O (CsF) films (stoichiometry CsF.1.5H2O) gradually transform into a mixed layer containing F, Cs, and H2O species.	Water	48-51	colony stimulating factor 2	Homo sapiens	13-16
16853033-4	2005	Above 110 K, CsF (H2O) layers deposited on thin H2O (CsF) films (stoichiometry CsF.1.5H2O) gradually transform into a mixed layer containing F, Cs, and H2O species.	Water	48-51	colony stimulating factor 2	Homo sapiens	13-16
31298842-6	2019	Concentrations in tap water samples ranged from 0.07 mug/L to 11.5 mug/L while the HMSA concentrations in surface waters were in the range of 100 ng/L.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
16853033-6	2005	When CsF is deposited at 120 K on sufficiently thick water multilayers, full solvation of both F and Cs takes place, even for the species closest to the surface, as long as the stoichiometry remains CsF.	Water	53-58	colony stimulating factor 2	Homo sapiens	5-8
16084384-5	2005	The PSBD achieves this dual recognition largely through the addition of a network of interfacial water molecules unique to the E1-PSBD complex.	Water	97-102	small nucleolar RNA, H/ACA box 73A	Homo sapiens	127-134
31387298-0	2019	A Unique Interactive Nanostructure Knitting based Passive Sampler Adsorbent for Monitoring of Hg2+ in Water.	Water	102-107	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	94-97
31387298-5	2019	The adsorption efficiency of g-CN for binding Hg2+ (100 ng mL-1) in sea, river, rain, and Milli-Q quality water was 89%, 93%, 97%, and 100%, respectively, at natural pH.	Water	106-111	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	46-49
30527279-0	2019	Tap water: A possible source of nontuberculous mycobacterial infection in patients with T cell deficiency.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
16024729-8	2005	In the kidney of the triply NOS-/- mice, vasopressin-induced cAMP production and membranous aquaporin-2 water channel expression were reduced associated with tubuloglomerular lesion formation.	Water	104-109	aquaporin 2	Mus musculus	92-103
30296361-2	2019	Consequently, a water-soluble carboxymethylcellulose sodium/sodium alginate/chitosan (CMC-Na/SA/CS) composite hydrogel has been developed as a potential burn wound dressing, with orthogonal testing revealing an optimal ratio of CMC-Na, SA, and CS as 2, 3, and 1 wt % for hydrogel preparation, respectively.	Water	16-21	IK cytokine	Rattus norvegicus	244-261
31161541-5	2019	Short-chain n-alkanes (C15, C17, and C19) in the sediments varied in abundance from 10.0 to 76.2 mug/g TOC across the study and showed a moderate correlation with total phosphorus (TP) concentrations in the overlying water.	Water	217-222	placenta associated 8	Homo sapiens	23-26
29882022-4	2019	Using genetic manipulation and pharmaceutical approaches, one can elucidate the role of secretin in mediating various neurological functions from simple behaviors, such as water and food intake, to more complex functions including emotion, motor, and learning or memory.	Water	172-177	secretin	Homo sapiens	88-96
15922355-1	2005	Located in the principal cells of the collecting duct, aquaporin-2 (AQP2) is responsible for the regulated water reabsorption in the kidney and is indispensable for the maintenance of body water balance.	Water	107-112	aquaporin 2	Homo sapiens	55-66
31074186-6	2019	The developed method was applied for the determination of the emerging contaminants in tap water, municipal water, ground water, sewage water, and sludge water samples.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
31026525-3	2019	Compared with the traditional starch-based wood adhesive, the water resistance of starch-based adhesive with NMA (SWA-N) was greatly improved to more than 1 MPa; this exceeds the Chinese standard by 40%.	Water	62-67	RNA binding motif protein 12	Homo sapiens	114-119
30980198-1	2019	Aquaporin 4 (AQP4) is a primary water channel found on astrocytes in the central nervous system (CNS).	Water	32-37	aquaporin 4	Homo sapiens	0-11
15922355-1	2005	Located in the principal cells of the collecting duct, aquaporin-2 (AQP2) is responsible for the regulated water reabsorption in the kidney and is indispensable for the maintenance of body water balance.	Water	107-112	aquaporin 2	Homo sapiens	68-72
30980198-1	2019	Aquaporin 4 (AQP4) is a primary water channel found on astrocytes in the central nervous system (CNS).	Water	32-37	aquaporin 4	Homo sapiens	13-17
31391443-2	2019	The spectrum of the disease has expanded based on the specificity of the autoimmune response to the aquaporin-4 (AQP-4) water channel expressed on the end feet of astrocytes in the central nervous system.	Water	120-125	aquaporin 4	Homo sapiens	100-111
31391443-2	2019	The spectrum of the disease has expanded based on the specificity of the autoimmune response to the aquaporin-4 (AQP-4) water channel expressed on the end feet of astrocytes in the central nervous system.	Water	120-125	aquaporin 4	Homo sapiens	113-118
30980198-2	2019	Besides its function in water and ion homeostasis, AQP4 has also been documented to be involved in a myriad of acute and chronic cerebral pathologies, including autoimmune neurodegenerative diseases.	Water	24-29	aquaporin 4	Homo sapiens	51-55
30980530-8	2019	Moreover, we observed that tomato gpat6-a mutants had an impaired cell wall-cuticle continuum and fewer stomata, but showed increased water loss.	Water	134-139	glycerol-3-phosphate 2-O-acyltransferase 6	Solanum lycopersicum	34-39
15962041-1	2005	The P4 molecule bound to ruthenium as an eta1-ligand in [CpRu(PPh3)2(eta1-P4)]Y (Y = PF6, CF3SO3) undergoes an easy reaction with water in exceedingly mild conditions to yield PH3, which remains coordinated to the [CpRu(PPh3)2] fragment, and oxygenated derivatives.	Water	130-135	secreted phosphoprotein 1	Homo sapiens	41-45
31004497-0	2019	AtEDT1/HDG11 regulates stomatal density and water-use efficiency via ERECTA and E2Fa.	Water	44-49	homeodomain GLABROUS 11	Arabidopsis thaliana	0-6
31004497-0	2019	AtEDT1/HDG11 regulates stomatal density and water-use efficiency via ERECTA and E2Fa.	Water	44-49	homeodomain GLABROUS 11	Arabidopsis thaliana	7-12
31255058-1	2019	We present a spin-1, three-state Ising model for the unusual thermodynamics of fluid water.	Water	85-90	spindlin 1	Homo sapiens	13-19
31255058-4	2019	Its mean-field equation of state enables a satisfactory description of results from experiments and simulations for the ST2 and TIP4P/2005 force fields, from the phase diagram, the density maximum, or the deeply "stretched" states to the behavior of thermodynamic response functions at low temperatures at which water exists as a supercooled liquid.	Water	312-317	ST2	Homo sapiens	120-123
31026539-7	2019	We therefore calculated the allowable concentration in water by allocating a small percentage of the indoor air guideline value to indirect inhalation exposure via volatilization from tap water.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	184-187
15962041-1	2005	The P4 molecule bound to ruthenium as an eta1-ligand in [CpRu(PPh3)2(eta1-P4)]Y (Y = PF6, CF3SO3) undergoes an easy reaction with water in exceedingly mild conditions to yield PH3, which remains coordinated to the [CpRu(PPh3)2] fragment, and oxygenated derivatives.	Water	130-135	secreted phosphoprotein 1	Homo sapiens	69-73
31026539-7	2019	We therefore calculated the allowable concentration in water by allocating a small percentage of the indoor air guideline value to indirect inhalation exposure via volatilization from tap water.	Water	188-193	nuclear RNA export factor 1	Homo sapiens	184-187
31031576-1	2019	A full-scale reproduction of an aircraft drinking water system was conditioned using municipal tap water with a mixture of free chlorine and chloramines, and subsequently contaminated with coliforms.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	95-98
31031576-1	2019	A full-scale reproduction of an aircraft drinking water system was conditioned using municipal tap water with a mixture of free chlorine and chloramines, and subsequently contaminated with coliforms.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
31139793-7	2019	Such a H3O+ ion has an extremely low barrier to proton transfer back to the surface site in comparison to a H3O+ ion in bulk water.	Water	125-130	H3 clustered histone 15	Homo sapiens	7-10
15741609-9	2005	Membrane vesicles isolated from oocytes expressing aquaporin-1 exhibited fourfold higher water permeability in stopped-flow experiments.	Water	89-94	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	51-62
31139793-7	2019	Such a H3O+ ion has an extremely low barrier to proton transfer back to the surface site in comparison to a H3O+ ion in bulk water.	Water	125-130	H3 clustered histone 15	Homo sapiens	108-111
15966863-9	2005	The key role of AQP3 in epidermal physiology might be exploited in the development of improved cosmetics and new therapies for skin diseases associated with altered skin water content.	Water	170-175	aquaporin 3 (Gill blood group)	Homo sapiens	16-20
31596261-1	2019	We investigated how UV treatment of indoor pool water affects the concentration of trihalomethanes (THMs) and chloramines (NCl3) in the air above one therapy pool.	Water	48-53	calpain 5	Homo sapiens	123-127
16027067-5	2005	CONCLUSION: AQP4 is expressed in alveolar type II cells in rats, and may play a role in water transportation in the respiratory system.	Water	88-93	aquaporin 4	Rattus norvegicus	12-16
31268335-2	2019	In this essay, we prepared a new cluster-based CaII-MOFs {[Ca1.5(mu8-HL1)(DMF)2] DMF}n (1) with good water dispersibility, excellent photoluminescence properties (FL quantum yield of 20.37%) and great fluorescence stability.	Water	101-106	carbonic anhydrase 2	Homo sapiens	47-51
30878926-0	2019	Characteristics and secondary formation of water-soluble organic acids in PM1, PM2.5 and PM10 in Beijing during haze episodes.	Water	43-48	transmembrane protein 11	Homo sapiens	74-77
30878926-5	2019	Multiple linear regression was used to tentatively quantify the relative contributions of photochemical oxidation and aqueous-phase oxidation to the formation of total water-soluble organic acids in PM1, PM2.5 and PM10 during haze episodes.	Water	168-173	transmembrane protein 11	Homo sapiens	199-202
31354298-2	2019	Besides, IMD-0354 can inhibit a variety of tumor cells in culture, but its poor water solubility and low utilization have limited its clinical application.	Water	80-85	adrenomedullin 2	Mus musculus	9-12
16089144-1	2005	OBJECTIVE: To investigate effects of electro-acupuncture (EA) on Du Meridian on the water channel aquaporin-4 (AQP-4) expression and hind limbs function recovery in experimental spinal cord injured rats.	Water	84-89	aquaporin 4	Rattus norvegicus	111-116
31212763-5	2019	NMOSD is frequently associated with antibodies which target aquaporin-4 (AQP4), the most abundant water channel in the CNS, located in the astrocytic processes at the blood-brain barrier (BBB).	Water	98-103	aquaporin 4	Homo sapiens	60-71
31009894-9	2019	KNTs were applied successfully in realistic purification of tap water, groundwater, and sewage water from the inspected metals.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
31212763-5	2019	NMOSD is frequently associated with antibodies which target aquaporin-4 (AQP4), the most abundant water channel in the CNS, located in the astrocytic processes at the blood-brain barrier (BBB).	Water	98-103	aquaporin 4	Homo sapiens	73-77
16852444-3	2005	The ISM-2 has been applied to the molecular dynamics simulations of (i) the single n-hexane droplets of different sizes in water and (ii) the single micelle composed of 30 n-decyltrimethylammonium chloride (C10TAC) cationic surfactants.	Water	123-128	isthmin 2	Homo sapiens	4-9
31308429-6	2019	The calculated free energies also supported the VFD of T1R2 monomer as the preferential binding site for such polyols, rather than T1R3 region, in accord with the lower number of accessible water molecules in the T1R2 pocket.	Water	190-195	taste 1 receptor member 2	Homo sapiens	55-59
31308429-6	2019	The calculated free energies also supported the VFD of T1R2 monomer as the preferential binding site for such polyols, rather than T1R3 region, in accord with the lower number of accessible water molecules in the T1R2 pocket.	Water	190-195	taste 1 receptor member 2	Homo sapiens	213-217
16852444-4	2005	As a result, it was found that the ISM-2 can mimic the n-hexane/water interface and represent the fluidity of the hydrocarbon interior of the surfactant micelle that the original ISM fails to do.	Water	64-69	isthmin 2	Homo sapiens	35-40
31041862-3	2019	During the anodic oxidation processes, the NTf2- anion is oxidized to form NTf2  radical and CO is oxidized to CO2 and produces a proton in these ILs when a trace amount of water is present.	Water	173-178	nuclear transport factor 2	Homo sapiens	43-47
16191654-5	2005	The maximum surge coincided closely in time with tidal high water, producing very high water levels along the coasts of the southern North Sea.	Water	87-92	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	139-142
31041862-3	2019	During the anodic oxidation processes, the NTf2- anion is oxidized to form NTf2  radical and CO is oxidized to CO2 and produces a proton in these ILs when a trace amount of water is present.	Water	173-178	nuclear transport factor 2	Homo sapiens	75-79
30415431-6	2019	Most used tap water (89%) in an enema bottle (50%) or rubber bulb (43%), and douched for cleanliness (97%), to avoid smelling bad (65%), and to enhance pleasure (24%).	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
15859952-9	2005	CONCLUSIONS: The pattern of subcellular distribution of AQP8 and AQP1 strongly corroborates the hypothesis of a transcellular route for the movement of water across the gall-bladder epithelium.	Water	152-157	aquaporin 8	Mus musculus	56-60
15859952-10	2005	Osmotic water would cross the apical membrane through AQP8 and AQP1, although AQP1 would be the facilitated pathway for the movement of water across the basolateral membrane.	Water	8-13	aquaporin 8	Mus musculus	54-58
15913339-3	2005	Our magnetic circular dichroism and electron paramagnetic resonance spectroscopic studies reported here reveal that, in the absence of ATP, the interaction between Co2+Cbl and hATR promotes partial conversion of the cofactor to its "base-off" form in which a water molecule occupies the lower axial position.	Water	259-264	complement C2	Homo sapiens	164-167
31056665-2	2019	Approximately 75% of NMOSD patients harbour circulating pathogenic autoantibodies targeting the aquaporin-4 water channel (AQP4).	Water	108-113	aquaporin 4	Homo sapiens	123-127
15913339-3	2005	Our magnetic circular dichroism and electron paramagnetic resonance spectroscopic studies reported here reveal that, in the absence of ATP, the interaction between Co2+Cbl and hATR promotes partial conversion of the cofactor to its "base-off" form in which a water molecule occupies the lower axial position.	Water	259-264	Cbl proto-oncogene	Homo sapiens	168-171
31042818-1	2019	Water was bubbled with gases including nitrogen (N2 ), oxygen (O2 ), hydrogen (H2 ), carbon dioxide (CO2 ), and air for 10 min and phenolics from green tea leaves were extracted using the prepared gas-bubbled water.	Water	0-5	relaxin 2	Homo sapiens	69-81
15931381-1	2005	Atrial natriuretic peptide (ANP) acts acutely to reduce plasma volume by at least 3 mechanisms: increased renal excretion of salt and water, vasodilation, and increased vascular permeability.	Water	134-139	natriuretic peptide type A	Mus musculus	0-26
15931381-1	2005	Atrial natriuretic peptide (ANP) acts acutely to reduce plasma volume by at least 3 mechanisms: increased renal excretion of salt and water, vasodilation, and increased vascular permeability.	Water	134-139	natriuretic peptide type A	Mus musculus	28-31
15948039-2	2005	METHODS: Reporter plasmid DNA encoding for beta-galactosidase (pCMV-beta) was encapsulated in gelatin and PEGylated gelatin nanoparticles using a water-ethanol solvent displacement method under controlled pH and temperature.	Water	146-151	galactosidase, beta 1	Mus musculus	43-61
30242727-0	2019	Myelin Water Fraction Imaging Reveals Hemispheric Asymmetries in Human White Matter That Are Associated with Genetic Variation in PLP1.	Water	7-12	proteolipid protein 1	Homo sapiens	130-134
30242727-3	2019	Here, we investigated the relation of genetic variation within PLP1 and white matter microstructure as assessed with myelin water fraction imaging, a neuroimaging technique that has the advantage over conventional diffusion tensor imaging in that it allows for a more direct assessment of myelin content.	Water	124-129	proteolipid protein 1	Homo sapiens	63-67
30242727-5	2019	Importantly, these parietal myelin water fraction asymmetries were associated with genetic variation in PLP1.	Water	35-40	proteolipid protein 1	Homo sapiens	104-108
15879344-8	2005	RESULTS: VEGF expression was observed in the cytoplasm of neurons exclusively in the area of vasogenic edema that was shown as a high-intensity area in the apparent diffusion coefficient of water map.	Water	190-195	vascular endothelial growth factor A	Rattus norvegicus	9-13
31151185-6	2019	However, for tap water, a high-surface-tension solvent, it has relatively low fragmentation degree, and good dispersion and exfoliation effects due to the hydrophilicity of GNPs.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
15907589-2	2005	The flavoprotein SMO is the most recently characterized catabolic enzyme, preferentially oxidizing SPM to SPD, 3-aminopropanal and H(2)O(2).	Water	131-136	smoothened, frizzled class receptor	Mus musculus	17-20
31066555-7	2019	On the basis of DFT calculations, this ligand-promoted hydrolysis is caused by strong hydrogen bonds forming between Gluc- and Mg(H2O)62+.	Water	130-133	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	117-121
15837307-1	2005	Cleavage of 4-pyrrole phenylacyl TentaGel-appended peptide (5) containing Arg(Pbf) with trifluoroacetic acid/triisopropylsilane/phenol/H2O (90/2/4/4) gives the 4-pyrrole phenylacyl peptide (3).	Water	135-138	zinc finger protein 395	Homo sapiens	78-81
30942602-2	2019	The Pd@Hal was found to be a highly efficient room-temperature catalyst for Suzuki-Miyaura cross-coupling reactions that gave high yields of a diverse array of coupling products in 5:2 n-PrOH/H2O within 1 h. The catalytic system was remarkably effective with a broad substrate scope.	Water	192-195	histidine ammonia-lyase	Homo sapiens	7-10
30738161-7	2019	The increased pure water permeability for CA-5 and CAP-5 hollow fiber membrane was 61.47 L/m2h bar and 69.60 L/m2 h bar, respectively.	Water	19-24	carbonic anhydrase 5A	Homo sapiens	42-46
15661970-12	2005	This occurs by increasing channel-mediated water transport, as reflected in an increase in AQP1 protein abundance and a higher Pf/P(DW) ratio.	Water	43-48	aquaporin-1	Oryctolagus cuniculus	91-95
31193542-10	2019	Volume fraction of bound water (BW) of the whole femur was 14% lower in anti-VEGF than in VEH mice (p = 0.003).	Water	25-30	vascular endothelial growth factor A	Mus musculus	77-81
15956686-7	2005	Relaxin-3 was found to bind to and activate native relaxin receptors in vitro and stimulate water drinking through central relaxin receptors in vivo.	Water	92-97	relaxin 3	Homo sapiens	0-9
30763841-12	2019	VPRs were quantified in 20% of the tap water samples.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
15864504-5	2005	When human OAT3 (hOAT3) and hOAT4 were expressed in Xenopus laevis oocytes, only hOAT3 showed [3H]cortisol uptake in excess of that of water-injected control oocytes.	Water	135-140	solute carrier family 22 member 8	Homo sapiens	11-15
15864504-5	2005	When human OAT3 (hOAT3) and hOAT4 were expressed in Xenopus laevis oocytes, only hOAT3 showed [3H]cortisol uptake in excess of that of water-injected control oocytes.	Water	135-140	solute carrier family 22 member 8	Homo sapiens	81-86
15705590-7	2005	This study is the first demonstration that PLD2 activation is implicated in Src-dependent phosphorylation of Pyk2 (Tyr(580) and Tyr(881)) by promoting the complex formation between Pyk2 and activated Src in PC12 cells exposed to H(2)O(2), thereby resulting in activation of the survival signaling pathway PI3K/Akt/p70S6K.	Water	229-234	phospholipase D2	Rattus norvegicus	43-47
15792470-0	2005	Solubility, complex formation, and redox reactions in the Tl2O3-HCN/CN(-)-H2O system.	Water	74-77	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	64-67
15792470-10	2005	Along with the acidic leaching (enhanced by Tl(III)-CN- complex formation), an effective reductive dissolution of the thallium(III) oxide can also take place in the Tl2O3-HCN-H2O system yielding thallium(I), while hydrogen cyanide is oxidized to cyanogen.	Water	175-178	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	171-174
15799775-0	2005	Effects of cold-water immersion on VEGF mRNA and protein expression in heart and skeletal muscles of rats.	Water	16-21	vascular endothelial growth factor A	Rattus norvegicus	35-39
15576658-0	2005	Intermedin/adrenomedullin-2 acts within central nervous system to elevate blood pressure and inhibit food and water intake.	Water	110-115	adrenomedullin 2	Rattus norvegicus	0-10
15576658-0	2005	Intermedin/adrenomedullin-2 acts within central nervous system to elevate blood pressure and inhibit food and water intake.	Water	110-115	adrenomedullin 2	Rattus norvegicus	11-27
15576658-10	2005	Intracerebroventricular administration of IMD also inhibited food and water intake in sated and in food- and water-restricted animals.	Water	70-75	adrenomedullin 2	Rattus norvegicus	42-45
32184700-9	2019	The decrease of the dissolved mass of Ag+ in tap water could be due to the reaction between Ag+ and Cl-, forming AgCl and affecting their dissolution.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
15576658-10	2005	Intracerebroventricular administration of IMD also inhibited food and water intake in sated and in food- and water-restricted animals.	Water	109-114	adrenomedullin 2	Rattus norvegicus	42-45
15780094-1	2005	BACKGROUND: Guanylin and uroguanylin link intestinal and renal electrolyte and water transport.	Water	79-84	guanylate cyclase activator 2A	Homo sapiens	12-20
30239145-2	2019	The use of a stable and well-defined manganese pincer complex, stabilized by a PNN ligand, together with a catalytic amount of base enabled the conversion of renewable alcohol feedstocks to a broad range of higher-value alcohols in good yields with water as the sole byproduct.	Water	249-254	pinin, desmosome associated protein	Homo sapiens	79-82
31334211-7	2019	Positive trends were observed for knowing that tap water with fluoride prevents cavities and that poor oral health of parents affects their children"s dental health.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
16833532-2	2005	Full geometry optimizations of the 5-fluorouracil-water complexes were carried out at the MP2/6-31+G(d,p) level of theory.	Water	50-55	tryptase pseudogene 1	Homo sapiens	90-98
31334211-10	2019	Significant positive improvements were found regarding caregiver"s favorable attitude that fluoridated water can help prevent cavities, disagreeing that tap water is dangerous, and agreeing that a parent"s dental health affects their children"s dental health.	Water	157-162	nuclear RNA export factor 1	Homo sapiens	153-156
31265451-3	2019	The number of genes participating in alkane degradation (alkB) or PAH-ring hydroxylation (PAH-RHDalpha) were detected by qPCR in all water and sediment samples.	Water	133-138	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	57-61
16833532-9	2005	The minimum energy path (MP2/6-31+G(d,p)) for water-assisted proton transfer in trihydrated 5-fluorouracil was followed.	Water	46-51	tryptase pseudogene 1	Homo sapiens	25-28
16526216-7	2005	DISCUSSION: Differences between these groups can be explained by various values of body mass index, by activity of lipoprotein lipase in athletes, by body position during the sports activity, by thermoregulatory vasoconstriction in the water, and by effects of hydrostatic pressure and reflex mechanisms during swimming.	Water	236-241	lipoprotein lipase	Homo sapiens	115-133
30964709-3	2019	Chow-fed 17-wk-old female Apoe-/- mice treated with 4-PBA-supplemented drinking water for 5 wk exhibited smaller lesions as well as increased plasma levels of heat shock protein (HSP) 25, the mouse homolog of human HSP27, compared with controls.	Water	80-85	heat shock protein 1	Mus musculus	159-186
30964709-6	2019	In summary, drinking water containing 4-PBA attenuated early lesion growth in Apoe-/- mice fed a chow diet and increased expression of HSP25 and HSP27 in macrophages and HSP25 in the circulation of Apoe-/- mice.	Water	21-26	heat shock protein 1	Mus musculus	135-140
30964709-6	2019	In summary, drinking water containing 4-PBA attenuated early lesion growth in Apoe-/- mice fed a chow diet and increased expression of HSP25 and HSP27 in macrophages and HSP25 in the circulation of Apoe-/- mice.	Water	21-26	heat shock protein 1	Mus musculus	145-150
30964709-6	2019	In summary, drinking water containing 4-PBA attenuated early lesion growth in Apoe-/- mice fed a chow diet and increased expression of HSP25 and HSP27 in macrophages and HSP25 in the circulation of Apoe-/- mice.	Water	21-26	heat shock protein 1	Mus musculus	170-175
15713463-9	2005	On the basis of the present crystal structure of the hCNP-CF/phosphate complex, the available structure of the CPDase/cyclic-nucleotide analogue complex, and the recent functional studies of rat CNP-CF, we propose a possible substrate-binding mode and catalytic mechanism of CNP, which employs the nucleophilic water molecule activated by His310.	Water	311-316	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	54-57
30914277-2	2019	Aquaporin-4 (AQP4) is the important water channel expressed in the astrocytes, and maintains the water homeostasis of the brain.	Water	36-41	aquaporin 4	Mus musculus	0-11
30914277-2	2019	Aquaporin-4 (AQP4) is the important water channel expressed in the astrocytes, and maintains the water homeostasis of the brain.	Water	36-41	aquaporin 4	Mus musculus	13-17
15713463-9	2005	On the basis of the present crystal structure of the hCNP-CF/phosphate complex, the available structure of the CPDase/cyclic-nucleotide analogue complex, and the recent functional studies of rat CNP-CF, we propose a possible substrate-binding mode and catalytic mechanism of CNP, which employs the nucleophilic water molecule activated by His310.	Water	311-316	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	195-198
30923833-2	2019	We and others have previously demonstrated that exposure to copper through drinking water significantly increased parenchymal amyloid-beta (Abeta) plaques and decreased endothelial low-density lipoprotein receptor-related protein 1 (LRP1) in mouse models of AD.	Water	84-89	low density lipoprotein receptor-related protein 1	Mus musculus	181-231
15671159-0	2005	Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution.	Water	53-58	aquaporin 6	Homo sapiens	14-25
30923833-2	2019	We and others have previously demonstrated that exposure to copper through drinking water significantly increased parenchymal amyloid-beta (Abeta) plaques and decreased endothelial low-density lipoprotein receptor-related protein 1 (LRP1) in mouse models of AD.	Water	84-89	low density lipoprotein receptor-related protein 1	Mus musculus	233-237
30923833-6	2019	In mice, a significant reduction of LRP1 in cortical vasculature was evident following 9 months exposure to 1.3 ppm copper in drinking water, although the levels of cortical microRNA-205-5p, -200b-3p, and -200c-3p were only marginally elevated.	Water	135-140	low density lipoprotein receptor-related protein 1	Mus musculus	36-40
15671159-1	2005	Aquaporin (AQP) 6 belongs to the aquaporin water channel family.	Water	43-48	aquaporin 6	Homo sapiens	11-17
31190541-4	2019	By virtue of the selective separation function of NF membrane and in situ production of organic acid/electron donor with GOx, a synergism effect of separation and reaction in the liquid/solid interface was manipulated for engineering the microenvironment of HRP to enhance its activity and stability for micropollutant removal in water.	Water	330-335	hydroxyacid oxidase 1	Homo sapiens	121-124
15671159-2	2005	Unlike other aquaporins, AQP6 functions not as a water channel but as an anion-selective channel.	Water	49-54	aquaporin 6	Homo sapiens	25-29
15742469-0	2005	Water-catalyzed dehalogenation reactions of the isomer of CBr4 and its reaction products and a comparison to analogous reaction of the isomers of di-and trihalomethanes.	Water	0-5	carbonyl reductase 4	Homo sapiens	58-62
31195378-0	2019	Fluorescent ZnO quantum dots synthesized with urea for the selective detection of Cr6+ ion in water with a wide range of concentrations.	Water	94-99	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	82-85
30928749-8	2019	Ship-borne phosphorus input results in a decrease of phosphate content in the water and increase of phosphorus binding to sediments.	Water	78-83	inositol polyphosphate-5-phosphatase D	Homo sapiens	0-4
15742469-1	2005	A combined experimental and theoretical study of the UV photolysis of a typical tetrahalomethane, CBr4, in water and acetonitrile/water was performed.	Water	107-112	carbonyl reductase 4	Homo sapiens	98-102
15742469-1	2005	A combined experimental and theoretical study of the UV photolysis of a typical tetrahalomethane, CBr4, in water and acetonitrile/water was performed.	Water	130-135	carbonyl reductase 4	Homo sapiens	98-102
15742469-2	2005	Ultraviolet photolysis of low concentrations of CBr4 in water mostly leads to the production of four HBr leaving groups and CO2.	Water	56-61	carbonyl reductase 4	Homo sapiens	48-52
15742469-3	2005	Picosecond time-resolved resonance Raman (Ps-TR3) experiments and ab initio calculations indicate that water-catalyzed O-H insertion/HBr elimination of the isomer of CBr4 and subsequent reactions of its products lead to the formation of these products.	Water	103-108	carbonyl reductase 4	Homo sapiens	166-170
31242665-3	2019	BLG was heated under dry conditions (water activity &lt; 0.7) and wet conditions (in phosphate buffer at pH 7.4) at low temperature (&lt;73  C) and high temperatures (&gt;90  C) in the presence or absence of the milk sugar lactose.	Water	37-42	beta-lactoglobulin	Bos taurus	0-3
15621188-14	2005	In all cases, the obtained results represent a substantial improvement over those obtained with the currently used Dow method: t(1/2) = 1.58 x 10(-8)((K(oc) x S)/P(S)), where S is the solubility of the compound in water.	Water	214-219	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	151-156
31460168-4	2019	Additionally, the sensitivity of NGOD- and AA-originated signal recovery from the Hg(II)-NGODs mixture has been successfully tested in Hg2+ ion-spiked tap water from three different places.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	151-154
31179460-6	2019	Fractionation by ultra-filtration and sequential liquid-liquid extraction showed that the compounds responsible for the inhibition are water-soluble with low molecular weights (<3 kDa) and that action could be through the following five compounds: ergothioneine, adenine, guanine, hypoxanthine, and xanthine, which are present in all fractions (UF-3, AqF-3 kDa and organic fractions) showing NS3/4A inhibition.	Water	135-140	KRAS proto-oncogene, GTPase	Homo sapiens	392-395
15689218-1	2005	Magnesium salts, the prevalent minerals in Dead Sea water, are known to exhibit favorable effects in inflammatory diseases.	Water	52-57	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	48-51
31140794-4	2019	When the concentration is in the mM range, the binding occurs with cis-VOL2(H2O), L = ma, koj, dhp, and mim, or with VO(acac)2: in the first case, the equatorial coordination of His68, Glu16, Glu18, or Asp21 residues yields species with formula n[VOL2]-Ub where n = 2-3, while with VO(acac)2 only noncovalent surface interactions are revealed.	Water	76-79	beta-secretase 2	Homo sapiens	202-207
15689218-7	2005	Bathing in the Dead Sea salt solution significantly improved skin barrier function compared with the tap water-treated control forearm in the subgroup with elevated basal TEWL.	Water	105-110	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	20-23
15641149-7	2005	RESULTS: In histopathological changes and RT-PCR analysis, sterile water-treated mice showed significant hyperplasia of the gastric mucosa with a significantly increased expression of mutant p53 mRNA compared to mice treated with PG for 8 wk.	Water	67-72	transformation related protein 53, pseudogene	Mus musculus	191-194
30722875-0	2019	Water-soluble beta-1,3-glucan prepared by degradation of curdlan with hydrogen peroxide.	Water	0-5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	14-22
31202217-5	2019	We employ the ST2 water model, which exhibits an abrupt first-order-like phase transition from LDA to HDA, similar to that observed in experiments.	Water	18-23	ST2	Homo sapiens	14-17
31132052-5	2019	The CNF hydrogels maintain their shape throughout synthesis steps including covalent crosslinking, equilibration with precursor ions, metal reduction with high concentration reducing agent, rinsing in water, ethanol solvent exchange, and CO2 supercritical drying.	Water	201-206	NPHS1 adhesion molecule, nephrin	Homo sapiens	4-7
31068220-1	2019	Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer"s disease (AD) and other neurological conditions with prominent astrogliosis.	Water	22-27	aquaporin 4	Mus musculus	49-53
15780031-6	2005	The administration of inositol and/or IP6 in drinking water caused marked enhancement in the glutathione S-transferase (GST) activity.	Water	54-59	hematopoietic prostaglandin D synthase	Rattus norvegicus	93-118
30933482-4	2019	During the sampling time, both high relative humidity (RH, ranged from 40% to 93%) and inorganic mass fraction in particles (62.6 +- 12.4% of dry particles, on average) resulted in abundant aerosol liquid water (43 +- 6% in the wet PM1, on average), which may liquefy the particles.	Water	205-210	transmembrane protein 11	Homo sapiens	232-235
31197617-8	2019	It was applied to spiked tap water samples and gave recoveries around 95 +- 5%.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
15780031-6	2005	The administration of inositol and/or IP6 in drinking water caused marked enhancement in the glutathione S-transferase (GST) activity.	Water	54-59	hematopoietic prostaglandin D synthase	Rattus norvegicus	120-123
15637337-2	2005	Using an RT-PCR technique, the relative quantities of nNOS mRNA as well as the tyrosine hydroxylase and phenylethanolamine N-methyltransferase mRNA in the adrenals of water-deprived rats significantly increased from 12 hr to 4 days.	Water	167-172	phenylethanolamine-N-methyltransferase	Rattus norvegicus	104-142
31205847-3	2019	This stability translates into increasing time efficiency of the synthesis and makes the protocol experimentally less demanding ("fast addition" not required, tap water can be used in the final steps) as compared to previously reported procedures, without compromising the size and shape monodispersity of the product.	Water	163-168	nuclear RNA export factor 1	Homo sapiens	159-162
31061505-3	2019	In the DLA process, diffuse Ag+ ions, which are generated by UV light illumination and dissolved by a thin adsorbed water layer on the surfaces of the Ag NPs and used GaN template, settle to form a BT through the combination with excited hot electrons migrating into the template from the Ag NPs.	Water	116-121	alcohol dehydrogenase iron containing 1	Homo sapiens	238-241
16374061-1	2005	There is evidence to suggest that water homeostasis in the inner ear is regulated via the vasopressin (VP)-aquaporin 2 (AQP2) system in the same fashion as in the kidney.	Water	34-39	aquaporin 2	Rattus norvegicus	120-124
31049691-10	2019	It was applied to the analysis of spiked water samples, and results compared favorably with those obtained by ICP-MS. Graphical abstract Schematic presentation of metal-ion-induced DNAzyme on magnetic bead (MB) with rolling circle amplification (RCA) for pH meter-based detection of lead(II) ion and by using a glucose oxidase (GOx)-labeled probe.	Water	41-46	hydroxyacid oxidase 1	Homo sapiens	311-326
31049691-10	2019	It was applied to the analysis of spiked water samples, and results compared favorably with those obtained by ICP-MS. Graphical abstract Schematic presentation of metal-ion-induced DNAzyme on magnetic bead (MB) with rolling circle amplification (RCA) for pH meter-based detection of lead(II) ion and by using a glucose oxidase (GOx)-labeled probe.	Water	41-46	hydroxyacid oxidase 1	Homo sapiens	328-331
30994094-7	2019	Filtered water samples from the Brazilian urban lake, however, showed the presence of bla OXA-48, bla KPC, bla VIM-2, qnrS, and aac(6")-lb-cr, whereas only bla VIM-2 was identified in raw sewage from Northeast Ohio.	Water	9-14	vimentin 2, pseudogene	Homo sapiens	111-116
16374061-2	2005	The VP-AQP2 system in the kidney is well known to be inhibited by lithium, resulting in polyuria due to a decrease in reabsorption of water in the collecting duct of the kidney.	Water	134-139	aquaporin 2	Rattus norvegicus	7-11
30879684-4	2019	In addition, with CNF concentrations of 0.01, 0.03, 0.05, and 0.10 wt%, CHF enhancement increases of 40.7%, 45.1%, 54.9%, and 69.4%, respectively, were achieved over that of pure water.	Water	179-184	NPHS1 adhesion molecule, nephrin	Homo sapiens	18-21
15509592-1	2004	Vasopressin regulates water homeostasis through insertion of homotetrameric aquaporin-2 (AQP2) water channels in the apical plasma membrane of renal cells.	Water	22-27	aquaporin 2	Homo sapiens	76-87
30879693-1	2019	In this study, water-soluble polysaccharide from Arctium lappa was extracted, isolated and purified to be a fraction (ALP-1).	Water	15-20	apolipoprotein A-I	Mus musculus	118-123
30761583-0	2019	The heterogeneous nature of water well fluoride levels in Sri Lanka: An opportunity to mitigate the dental fluorosis.	Water	28-33	sorcin	Homo sapiens	58-61
30864843-1	2019	Isoform 3 of the Na+/H+ exchanger (NHE3) is responsible for the majority of the reabsorption of NaCl, NaHCO3, and, consequently, water in the renal proximal tubule.	Water	129-134	solute carrier family 9 member A3	Homo sapiens	35-39
15509592-1	2004	Vasopressin regulates water homeostasis through insertion of homotetrameric aquaporin-2 (AQP2) water channels in the apical plasma membrane of renal cells.	Water	22-27	aquaporin 2	Homo sapiens	89-93
30802427-1	2019	Aquaporin 0 (AQP0) is essential for eye lens homeostasis as is regulation of its water permeability by Ca2+, which occurs through interactions with calmodulin (CaM), but the underlying molecular mechanisms are not well understood.	Water	81-86	carbonic anhydrase 2	Homo sapiens	103-106
31170009-0	2019	Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of U.S. Women.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
31170009-3	2019	OBJECTIVES: This study estimates the RSC of tap water to overall PFAS exposure among members of the general U.S. POPULATION:  METHODS: We measured concentrations of 15 PFAS in home tap water samples collected in 1989-1990 from 225 participants in a nationwide prospective cohort of U.S. women: the Nurses" Health Study (NHS).	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
31170009-4	2019	We used a one-compartment toxicokinetic model to estimate plasma concentrations corresponding to tap water intake of PFAS.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
15456785-0	2004	Copper inhibits the water and glycerol permeability of aquaporin-3.	Water	20-25	aquaporin 3 (Gill blood group)	Homo sapiens	55-66
31170009-6	2019	RESULTS: Tap water perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) were statistically significant predictors of plasma concentrations among individuals who consumed [Formula: see text] cups of tap water per day.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
31170009-6	2019	RESULTS: Tap water perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) were statistically significant predictors of plasma concentrations among individuals who consumed [Formula: see text] cups of tap water per day.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	209-212
31170009-6	2019	RESULTS: Tap water perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) were statistically significant predictors of plasma concentrations among individuals who consumed [Formula: see text] cups of tap water per day.	Water	213-218	nuclear RNA export factor 1	Homo sapiens	9-12
31170009-6	2019	RESULTS: Tap water perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) were statistically significant predictors of plasma concentrations among individuals who consumed [Formula: see text] cups of tap water per day.	Water	213-218	nuclear RNA export factor 1	Homo sapiens	209-212
30877104-1	2019	The glial water channel protein aquaporin-4 (AQP4) forms heterotetramers in the plasma membrane made of the M23-AQP4 and M1-AQP4 isoforms.	Water	10-15	aquaporin 4	Homo sapiens	32-43
30877104-1	2019	The glial water channel protein aquaporin-4 (AQP4) forms heterotetramers in the plasma membrane made of the M23-AQP4 and M1-AQP4 isoforms.	Water	10-15	aquaporin 4	Homo sapiens	45-49
30877104-1	2019	The glial water channel protein aquaporin-4 (AQP4) forms heterotetramers in the plasma membrane made of the M23-AQP4 and M1-AQP4 isoforms.	Water	10-15	aquaporin 4	Homo sapiens	112-116
15456785-3	2004	Here we report that both water and glycerol permeability of human AQP3 is inhibited by copper.	Water	25-30	aquaporin 3 (Gill blood group)	Homo sapiens	66-70
30877104-1	2019	The glial water channel protein aquaporin-4 (AQP4) forms heterotetramers in the plasma membrane made of the M23-AQP4 and M1-AQP4 isoforms.	Water	10-15	aquaporin 4	Homo sapiens	112-116
15607625-0	2004	Aquaporin-2 water channels in spontaneously hypertensive rats.	Water	12-17	aquaporin 2	Rattus norvegicus	0-11
30883015-1	2019	DNase I inhibitory potential of water extract of nine Hypericum species (H. umbellatum, H. barbatum, H. rumeliacum, H. rochelii, H. perforatum, H. tetrapterum, H. olympicum, H. hirsutum, H. linarioides) and the most important Hypericum secondary metabolites (hypericin, hyperforin, quercetin, and rutin) was investigated.	Water	32-37	deoxyribonuclease 1	Rattus norvegicus	0-7
30857416-6	2019	Interestingly, VAChT mutants showed no attentional deficits and only minor cognitive flexibility impairments while presenting large deficiencies in both spatial and cued Morris water maze (MWM) tasks.	Water	177-182	solute carrier family 18 (vesicular monoamine), member 3	Mus musculus	15-20
30791140-5	2019	The PVS closure was hypothesized to rely on swelling of astrocytic endfeet due to their high expression of aquaporin-4 (AQP4) water channels.	Water	126-131	aquaporin 4	Mus musculus	107-118
30763914-7	2019	The L20 resin could be reused after many adsorption-desorption cycles with most of its virgin adsorption capacity for advanced wastewater treatment, indicating its great potential for the selective and efficient removal of nitrate from large amounts of municipal wastewater or surface water.	Water	132-137	immunoglobulin kappa variable 3D-11	Homo sapiens	4-7
30791140-5	2019	The PVS closure was hypothesized to rely on swelling of astrocytic endfeet due to their high expression of aquaporin-4 (AQP4) water channels.	Water	126-131	aquaporin 4	Mus musculus	120-124
15607625-1	2004	Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension.	Water	135-140	aquaporin 2	Rattus norvegicus	116-127
15607625-1	2004	Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension.	Water	135-140	aquaporin 2	Rattus norvegicus	129-133
15541159-3	2004	Percentage of lifetime exposed to optimally fluoridated water pre- (PRE) and post-eruption (POST) was calculated with respect to tooth eruption age.	Water	56-61	solute carrier family 35 member G1	Homo sapiens	92-96
31005848-3	2019	In a previous study we demonstrated that MetS-like conditions induced by fructose in drinking water (10% v/v, during 21 days), significantly reduced the expression and activity of intestinal Mrp2 in rats.	Water	94-99	ATP binding cassette subfamily C member 2	Rattus norvegicus	191-195
30571992-2	2019	AIM: To investigate the dispersal of CRE from sinks in which water delivered from the tap flows directly into the drain and from clinical handwash basins with the drain at the rear.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	86-89
15477386-12	2004	We conclude that Slc26a4 is upregulated with NaCl restriction and is critical in the maintenance of acid-base balance and in the renal conservation of Cl- and water during NaCl restriction.	Water	159-164	solute carrier family 26, member 4	Mus musculus	17-24
30682660-6	2019	Low field-nuclear magnetic resonance results showed that UIF-180 decreased water migration during frozen storage.	Water	75-80	forty-two-three domain containing 1	Homo sapiens	57-60
31133138-6	2019	When spiked concentration was 1.0 mug/L for pure water and tap water, the recoveries were 94.8% and 93.7%, respectively, and relative standard deviation was 2.9% and 3.4%, respectively.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
31133138-7	2019	When spiked concentration was 16.0 mug/L for pure water and tap water, the recoveries were both 101% and relative standard deviation was 1.0% and 1.3%, respectively.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
30828737-10	2019	We suggest that PCaP1 contributes to hydrotropism through a MIZ1-independent pathway or as one of the upstream components that transduce water potential signals to MIZ1.	Water	137-142	plasma-membrane associated cation-binding protein 1	Arabidopsis thaliana	16-21
30921633-2	2019	The aim of this study was to investigate the influence of different water salinities on the expression of HSP70, PCNA and caspase-3 during spermatogenesis of Nile tilapia.	Water	68-73	heat shock cognate 71 kDa protein	Oreochromis niloticus	106-111
15545369-1	2004	A novel method for the separation of milk-fat globule membrane (MFGM) isolate by microfiltration in the presence of citrate was applied to prepare a fraction to be used to stabilize oil-in-water emulsions.	Water	189-194	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	37-62
30753876-8	2019	Mice administered CORT via drinking water showed susceptibility.	Water	36-41	cortistatin	Mus musculus	18-22
31100790-1	2019	Due to the strong absorption of water vapor at wavelengths of 1350-1420 nm and 1820-1940 nm, under normal atmospheric conditions, the actual digital number (DN) response curve of a hyperspectral imager deviates from the Gaussian shape, which leads to a decrease in the calibration accuracy of an instrument"s spectral response functions (SRF).	Water	32-37	serum response factor	Homo sapiens	338-341
30660975-2	2019	In this study, 64 tap water samples were collected from 8 counties (or county level cities) in Jinhua Region of Zhejiang Province, China.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
30660975-6	2019	Correlation analysis showed that DBPs occurrence in tap water was significantly related with physicochemical parameters.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
15545369-1	2004	A novel method for the separation of milk-fat globule membrane (MFGM) isolate by microfiltration in the presence of citrate was applied to prepare a fraction to be used to stabilize oil-in-water emulsions.	Water	189-194	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	64-68
30660975-7	2019	Principle component analysis further suggested that organic matter (DOC and UVA254) are the major factors influencing the occurrence of THMs, HAAs, HANs and HKs in tap water, while for HNMs, both the organic (DOC and UVA254) and inorganic factors (e.g. Temp, NO2--N, pH, Br- and NH4+-N) played important role in its formation.	Water	168-173	nuclear RNA export factor 1	Homo sapiens	164-167
15504347-6	2004	These results suggest that AVP might induce the expression of several genes related to the apical targeting of newly synthesized AQP2 as well as that of AQP2 for the long-term modification of water permeability in renal collecting duct.	Water	192-197	arginine vasopressin	Canis lupus familiaris	27-30
31041382-1	2019	alpha-Hemolysin (alphaHL), a beta-barrel pore-forming toxin (betaPFT), is secreted as a water-soluble monomer by Staphylococcus aureus.	Water	88-93	AT695_RS11870	Staphylococcus aureus	0-15
30772575-1	2019	The current investigation deals with how chemically activated carbon derived from industrial paper sludge (ACPS) performs on sorptive removal of enrofloxacin (ENF), an antibacterial drug from its water solution.	Water	196-201	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	107-111
15504347-6	2004	These results suggest that AVP might induce the expression of several genes related to the apical targeting of newly synthesized AQP2 as well as that of AQP2 for the long-term modification of water permeability in renal collecting duct.	Water	192-197	aquaporin 2	Canis lupus familiaris	129-133
31003396-0	2019	Microplastics Detection in Streaming Tap Water with Raman Spectroscopy.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
31017157-4	2019	Similar to the muscle of the gecko toe pads, the excellent shape memory effect of the PU-CNF substrate can help the obtained film to memorize and repeatedly display different shapes and solid/water contact models.	Water	192-197	NPHS1 adhesion molecule, nephrin	Homo sapiens	89-92
31003396-3	2019	However, for drinking and tap water, with its comparatively low biological loads, direct observation may be possible and allows a point-of-entry monitoring for beverages and food to ensure uncontaminated drinking water is being used.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
15504347-6	2004	These results suggest that AVP might induce the expression of several genes related to the apical targeting of newly synthesized AQP2 as well as that of AQP2 for the long-term modification of water permeability in renal collecting duct.	Water	192-197	aquaporin 2	Canis lupus familiaris	153-157
31003396-4	2019	In a proof of concept, we apply Raman spectroscopy to observe individual microplastic particles in tap water with added particulate and fluorescent contaminants streaming with 1 L/h through a custom-made flow cell.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
31003396-6	2019	The experiment promises the monitoring of streaming tap water and even clear surface waters for microplastics smaller than 0.1 mm.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
15518485-1	2004	Surface modification of 1,4-polybutadiene and cis-1,4-polyisoprene to introduce polar functional groups provided surfaces that reconstructed reversibly against water as a function of temperature.	Water	160-165	suppressor of cytokine signaling 1	Homo sapiens	46-51
30550968-8	2019	Moreover, the CDs/C11-Fe3O4 were also applied for the detection of BaP in large-volume water samples, which satisfies the China environmental protection standard, are promising candidates for water remediation.	Water	87-92	aldo-keto reductase family 1 member C4	Homo sapiens	18-21
30550968-8	2019	Moreover, the CDs/C11-Fe3O4 were also applied for the detection of BaP in large-volume water samples, which satisfies the China environmental protection standard, are promising candidates for water remediation.	Water	192-197	aldo-keto reductase family 1 member C4	Homo sapiens	18-21
31077750-6	2020	The TTR-TRbeta CALUX predicted 9/9 compounds and demonstrated competitive activities when analyzing waste water samples.	Water	106-111	transthyretin	Homo sapiens	4-7
30994331-5	2019	With water vapor as the catalyst for vibrational energy transfer, the sensor system using the novel surface grooved QTF achieved a CO minimum detection limit of 7 ppb for a 300 ms averaging time, which corresponds to a normalized noise equivalent absorption coefficient of 8.74 x 10-9 cm-1W / Hz.	Water	5-10	histatin 1	Homo sapiens	163-166
15451545-3	2004	A delivery system composed of RA/GCD inclusion complex was applied because RA is poorly water soluble, and organic solvents used to dissolve it often interfere with cytotoxicity.	Water	88-93	glutaryl-CoA dehydrogenase	Homo sapiens	33-36
30798218-4	2019	QN-1 can detect H2S specifically in aqueous phase, which indicated QN-1 has excellent water solubility.	Water	86-91	centrosomal protein 162	Homo sapiens	0-4
30798218-4	2019	QN-1 can detect H2S specifically in aqueous phase, which indicated QN-1 has excellent water solubility.	Water	86-91	centrosomal protein 162	Homo sapiens	67-71
30802796-7	2019	Furthermore, the sensor has been used for the detection of fluoride anion in tap water, ground water and human serum samples, the recovery can achieve 94.0%-103.3%, 94.7%-101.0% and 89.8-100.9%, respectively.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
30738082-3	2019	During the development of cytotoxic and subsequent ionic cerebral edema water enters the brain by moving across an intact blood brain barrier and through aquaporin-4 (AQP4) at astrocyte endfeet.	Water	72-77	aquaporin 4	Homo sapiens	154-165
30738082-3	2019	During the development of cytotoxic and subsequent ionic cerebral edema water enters the brain by moving across an intact blood brain barrier and through aquaporin-4 (AQP4) at astrocyte endfeet.	Water	72-77	aquaporin 4	Homo sapiens	167-171
30738082-4	2019	Using AQP4-expressing cells, we screened small molecule libraries for inhibitors that reduce AQP4-mediated water permeability.	Water	107-112	aquaporin 4	Homo sapiens	6-10
30738082-4	2019	Using AQP4-expressing cells, we screened small molecule libraries for inhibitors that reduce AQP4-mediated water permeability.	Water	107-112	aquaporin 4	Homo sapiens	93-97
31031597-2	2019	Most patients are positive for specific immunoglobulin G (IgG) auto-antibodies for aquaporin-4 (AQP4), a water channel present in astrocytes.	Water	105-110	aquaporin 4	Homo sapiens	83-94
31031597-2	2019	Most patients are positive for specific immunoglobulin G (IgG) auto-antibodies for aquaporin-4 (AQP4), a water channel present in astrocytes.	Water	105-110	aquaporin 4	Homo sapiens	96-100
30790554-12	2019	We found that containers with partial shade produce 4.6 times more pupae than without any shade, whereas in the excess zero group the expected number of observed zero pupae count is 86.5% lower in containers filled with rain water than those with tap water, tube-well water, ring well water and water from other sources.	Water	251-256	nuclear RNA export factor 1	Homo sapiens	247-250
30790554-12	2019	We found that containers with partial shade produce 4.6 times more pupae than without any shade, whereas in the excess zero group the expected number of observed zero pupae count is 86.5% lower in containers filled with rain water than those with tap water, tube-well water, ring well water and water from other sources.	Water	251-256	nuclear RNA export factor 1	Homo sapiens	247-250
30790554-12	2019	We found that containers with partial shade produce 4.6 times more pupae than without any shade, whereas in the excess zero group the expected number of observed zero pupae count is 86.5% lower in containers filled with rain water than those with tap water, tube-well water, ring well water and water from other sources.	Water	251-256	nuclear RNA export factor 1	Homo sapiens	247-250
30790554-12	2019	We found that containers with partial shade produce 4.6 times more pupae than without any shade, whereas in the excess zero group the expected number of observed zero pupae count is 86.5% lower in containers filled with rain water than those with tap water, tube-well water, ring well water and water from other sources.	Water	251-256	nuclear RNA export factor 1	Homo sapiens	247-250
15451545-4	2004	Solubility of RA in water was increased by forming complex with GCD.	Water	20-25	glutaryl-CoA dehydrogenase	Homo sapiens	64-67
15539762-1	2004	Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis.	Water	24-29	aquaporin 2	Homo sapiens	51-55
31459881-8	2019	Moreover, the analytical performance of the proposed probe was practically demonstrated to successfully monitor trace levels of TCS in samples of tap water and personal care products.	Water	150-155	nuclear RNA export factor 1	Homo sapiens	146-149
15539762-2	2004	Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts.	Water	79-84	aquaporin 2	Homo sapiens	15-19
30763638-1	2019	A Mg2+-water bridge between the C-3, C-4 diketo moiety of fluoroquinolones and the conserved amino acid residues in the GyrA/ParC subunit is critical for the binding of a fluoroquinolone to a topoisomerase-DNA covalent complex.	Water	7-12	complement C3	Homo sapiens	32-35
30997284-9	2019	Moreover, water temperature and DIN/DIP were significantly correlated with water level, indicating that water level changes have a direct effect on Anabaena and heterocyst formation in Poyang Lake.	Water	75-80	DIP	Homo sapiens	36-39
15477167-6	2004	Both the MP2 and B3LYP calculations located three minima corresponding to cyclic HCOOH...H2O complexes with two hydrogen bond interactions.	Water	89-92	tryptase pseudogene 1	Homo sapiens	9-12
30997284-9	2019	Moreover, water temperature and DIN/DIP were significantly correlated with water level, indicating that water level changes have a direct effect on Anabaena and heterocyst formation in Poyang Lake.	Water	75-80	DIP	Homo sapiens	36-39
30938427-1	2019	Pathogenic antibodies targeting the aquaporin-4 water channel on astrocytes are associated with relapsing inflammatory neuromyelitis optica spectrum disorders.	Water	48-53	aquaporin 4	Homo sapiens	36-47
30958797-1	2019	Neuromyelitis optica (NMO) is an autoimmune CNS disorder mediated by pathogenic aquaporin-4 (AQP4) water channel autoantibodies (AQP4-IgG).	Water	99-104	aquaporin 4	Homo sapiens	80-91
15388159-2	2004	In a program directed toward finding potent, water soluble inhibitors of Hsp90, we prepared a library of over sixty 17-alkylamino-17-demethoxygeldanamycin analogs, and compared their affinity for Hsp90, ability to inhibit growth of SKBr3 mammalian cells, and in selected cases, water solubility.	Water	45-50	heat shock protein 90 alpha family class A member 1	Homo sapiens	73-78
30958797-1	2019	Neuromyelitis optica (NMO) is an autoimmune CNS disorder mediated by pathogenic aquaporin-4 (AQP4) water channel autoantibodies (AQP4-IgG).	Water	99-104	aquaporin 4	Homo sapiens	93-97
30958797-1	2019	Neuromyelitis optica (NMO) is an autoimmune CNS disorder mediated by pathogenic aquaporin-4 (AQP4) water channel autoantibodies (AQP4-IgG).	Water	99-104	aquaporin 4	Homo sapiens	129-133
30863703-9	2019	Relation between the variation of urease activity and amount of heavy metals can be applied in biosensor development for determining the concentration of Cr6+ present in the water samples.	Water	174-179	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	154-157
31172009-4	2019	Acute colitis in PTPN2xVilCre mice was induced by 2% dextran sulfate sodium (DSS) in drinking water for 7 days.	Water	94-99	protein tyrosine phosphatase, non-receptor type 2	Mus musculus	17-22
30958906-12	2019	PRACTICAL APPLICATION: Gum tragacanth, xanthan gum, and sucrose monopalmitate have been used to formulate oil-in-water emulsions.	Water	113-118	OTU deubiquitinase with linear linkage specificity	Homo sapiens	23-26
30958906-12	2019	PRACTICAL APPLICATION: Gum tragacanth, xanthan gum, and sucrose monopalmitate have been used to formulate oil-in-water emulsions.	Water	113-118	OTU deubiquitinase with linear linkage specificity	Homo sapiens	47-50
15213068-2	2004	The antidiuretic hormone AVP plays an important role in renal water excretion by regulating the membrane insertion and abundance of the water channel aquaporin-2 (AQP2); this effect is primarily mediated via the V2 subtype of the AVP receptor (V2R).	Water	62-67	aquaporin 2	Rattus norvegicus	150-161
31198147-14	2019	Serum I-FABP level in the EHS+water and EHS+ORS III groups were notably lower than that in the EHS group [mug/L: 24.19 (20.00, 28.36), 0.31 (0.31, 5.58) vs. 36.90 (29.10, 45.00), both P &lt; 0.01], additionally, I-FABP level was much lower in the EHS+ORS III group (P &lt; 0.01).	Water	30-35	fatty acid binding protein 2	Rattus norvegicus	6-12
30935410-2	2019	Furthermore, the encasement of the central nervous system (CNS) by a hard structure, greatly limits its tolerance for the volume changes occurring with acute brain edema, which quickly leads to severe damage or death.The recent discovery of the extended isoform of AQP4 (AQP4ex), generated by translational readthrough, revealed a potential new mechanism of water transport regulation and polarization at the blood-brain-barrier level.In the present study we used CRISPR/Cas9 technology to generate an AQP4ex-/- mouse model and evaluate the effect on the overall AQP4 expression, polarization, supramolecular organization in orthogonal arrays of particles (OAPs) and neuromyelitis optica (NMO-IgG) autoantibodies binding.AQP4ex removal did not cause a decrease in total AQP4 protein expression but completely suppressed the specific location of AQP4 at the astrocyte endfeet.	Water	358-363	aquaporin 4	Mus musculus	265-269
30935410-2	2019	Furthermore, the encasement of the central nervous system (CNS) by a hard structure, greatly limits its tolerance for the volume changes occurring with acute brain edema, which quickly leads to severe damage or death.The recent discovery of the extended isoform of AQP4 (AQP4ex), generated by translational readthrough, revealed a potential new mechanism of water transport regulation and polarization at the blood-brain-barrier level.In the present study we used CRISPR/Cas9 technology to generate an AQP4ex-/- mouse model and evaluate the effect on the overall AQP4 expression, polarization, supramolecular organization in orthogonal arrays of particles (OAPs) and neuromyelitis optica (NMO-IgG) autoantibodies binding.AQP4ex removal did not cause a decrease in total AQP4 protein expression but completely suppressed the specific location of AQP4 at the astrocyte endfeet.	Water	358-363	aquaporin 4	Mus musculus	271-277
30935410-2	2019	Furthermore, the encasement of the central nervous system (CNS) by a hard structure, greatly limits its tolerance for the volume changes occurring with acute brain edema, which quickly leads to severe damage or death.The recent discovery of the extended isoform of AQP4 (AQP4ex), generated by translational readthrough, revealed a potential new mechanism of water transport regulation and polarization at the blood-brain-barrier level.In the present study we used CRISPR/Cas9 technology to generate an AQP4ex-/- mouse model and evaluate the effect on the overall AQP4 expression, polarization, supramolecular organization in orthogonal arrays of particles (OAPs) and neuromyelitis optica (NMO-IgG) autoantibodies binding.AQP4ex removal did not cause a decrease in total AQP4 protein expression but completely suppressed the specific location of AQP4 at the astrocyte endfeet.	Water	358-363	aquaporin 4	Mus musculus	271-275
30935410-2	2019	Furthermore, the encasement of the central nervous system (CNS) by a hard structure, greatly limits its tolerance for the volume changes occurring with acute brain edema, which quickly leads to severe damage or death.The recent discovery of the extended isoform of AQP4 (AQP4ex), generated by translational readthrough, revealed a potential new mechanism of water transport regulation and polarization at the blood-brain-barrier level.In the present study we used CRISPR/Cas9 technology to generate an AQP4ex-/- mouse model and evaluate the effect on the overall AQP4 expression, polarization, supramolecular organization in orthogonal arrays of particles (OAPs) and neuromyelitis optica (NMO-IgG) autoantibodies binding.AQP4ex removal did not cause a decrease in total AQP4 protein expression but completely suppressed the specific location of AQP4 at the astrocyte endfeet.	Water	358-363	aquaporin 4	Mus musculus	271-275
30935410-2	2019	Furthermore, the encasement of the central nervous system (CNS) by a hard structure, greatly limits its tolerance for the volume changes occurring with acute brain edema, which quickly leads to severe damage or death.The recent discovery of the extended isoform of AQP4 (AQP4ex), generated by translational readthrough, revealed a potential new mechanism of water transport regulation and polarization at the blood-brain-barrier level.In the present study we used CRISPR/Cas9 technology to generate an AQP4ex-/- mouse model and evaluate the effect on the overall AQP4 expression, polarization, supramolecular organization in orthogonal arrays of particles (OAPs) and neuromyelitis optica (NMO-IgG) autoantibodies binding.AQP4ex removal did not cause a decrease in total AQP4 protein expression but completely suppressed the specific location of AQP4 at the astrocyte endfeet.	Water	358-363	aquaporin 4	Mus musculus	271-275
30583431-4	2019	Green tea also generated H2O2; tea prepared on tap water generated significantly more H2O2 than tea prepared on deionized water.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
15213068-2	2004	The antidiuretic hormone AVP plays an important role in renal water excretion by regulating the membrane insertion and abundance of the water channel aquaporin-2 (AQP2); this effect is primarily mediated via the V2 subtype of the AVP receptor (V2R).	Water	62-67	aquaporin 2	Rattus norvegicus	163-167
31027312-2	2019	In this study, a homogeneous sulfated polysaccharide from the marine green alga Monostroma nitidum, designated MS-1, was isolated using water extraction and anion-exchange and size-exclusion chromatography.	Water	136-141	actin-binding Rho activating protein	Rattus norvegicus	111-115
15213068-7	2004	Moderate water restriction induced equivalent relative increases in renal AQP2 abundances in all age groups but resulted in significantly lower abundances in total kidney AQP2 protein in aged compared with young F344BN rats.	Water	9-14	aquaporin 2	Rattus norvegicus	74-78
15213068-7	2004	Moderate water restriction induced equivalent relative increases in renal AQP2 abundances in all age groups but resulted in significantly lower abundances in total kidney AQP2 protein in aged compared with young F344BN rats.	Water	9-14	aquaporin 2	Rattus norvegicus	171-175
30935410-2	2019	Furthermore, the encasement of the central nervous system (CNS) by a hard structure, greatly limits its tolerance for the volume changes occurring with acute brain edema, which quickly leads to severe damage or death.The recent discovery of the extended isoform of AQP4 (AQP4ex), generated by translational readthrough, revealed a potential new mechanism of water transport regulation and polarization at the blood-brain-barrier level.In the present study we used CRISPR/Cas9 technology to generate an AQP4ex-/- mouse model and evaluate the effect on the overall AQP4 expression, polarization, supramolecular organization in orthogonal arrays of particles (OAPs) and neuromyelitis optica (NMO-IgG) autoantibodies binding.AQP4ex removal did not cause a decrease in total AQP4 protein expression but completely suppressed the specific location of AQP4 at the astrocyte endfeet.	Water	358-363	aquaporin 4	Mus musculus	271-275
15380899-1	2004	BACKGROUND &amp; AIMS: Water soluble vitamins B1, B2 and B6 are essential precursors for a wide variety of coenzymes involved in intermediary metabolism and their status is usually assessed from blood samples.	Water	23-28	membrane spanning 4-domains A1	Homo sapiens	46-59
30935410-2	2019	Furthermore, the encasement of the central nervous system (CNS) by a hard structure, greatly limits its tolerance for the volume changes occurring with acute brain edema, which quickly leads to severe damage or death.The recent discovery of the extended isoform of AQP4 (AQP4ex), generated by translational readthrough, revealed a potential new mechanism of water transport regulation and polarization at the blood-brain-barrier level.In the present study we used CRISPR/Cas9 technology to generate an AQP4ex-/- mouse model and evaluate the effect on the overall AQP4 expression, polarization, supramolecular organization in orthogonal arrays of particles (OAPs) and neuromyelitis optica (NMO-IgG) autoantibodies binding.AQP4ex removal did not cause a decrease in total AQP4 protein expression but completely suppressed the specific location of AQP4 at the astrocyte endfeet.	Water	358-363	aquaporin 4	Mus musculus	271-275
30932814-0	2019	Low wnt/beta-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice.	Water	93-98	catenin (cadherin associated protein), beta 1	Mus musculus	8-20
31013316-9	2019	This experiment showed that the effect of drinking large volumes of hydrogen-rich water was not significantly different from that of normal water, in terms of preventing an increase in the size of cysts in PCK rats.	Water	82-87	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	206-209
30843538-4	2019	The highly selective response of this MOF probe to ceftriaxone sodium (an antibiotic) can reach up to the ppb level in water, along with a fast response time, acid and alkali resistance, and anti-interference ability.	Water	119-124	histatin 1	Homo sapiens	106-109
30943671-5	2019	Patient revealed that he injected drugs intravenously with tap water.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
30845802-15	2019	Fourth, after computing hydration pathways with water addition both syn and anti to C3, we found, in contrast to the results of our carboxylation study indicating anti addition, that in the oxygenation reaction only syn-hydration is capable of producing a stable gemdiolate that facilitates the rate-limiting C2-C3 bond scission to final products.	Water	48-53	synemin	Homo sapiens	68-71
15375773-7	2004	BK activates a G-protein coupled receptor, B2R, to regulate renal blood flow and salt and water excretion.	Water	90-95	bradykinin receptor B2	Homo sapiens	43-46
30845802-15	2019	Fourth, after computing hydration pathways with water addition both syn and anti to C3, we found, in contrast to the results of our carboxylation study indicating anti addition, that in the oxygenation reaction only syn-hydration is capable of producing a stable gemdiolate that facilitates the rate-limiting C2-C3 bond scission to final products.	Water	48-53	synemin	Homo sapiens	216-219
30680924-1	2019	Aquaporin-4 (AQP4), the main water-selective membrane transport protein in the brain, is localized to the astrocyte plasma membrane.	Water	29-34	aquaporin 4	Mus musculus	0-11
30680924-1	2019	Aquaporin-4 (AQP4), the main water-selective membrane transport protein in the brain, is localized to the astrocyte plasma membrane.	Water	29-34	aquaporin 4	Mus musculus	13-17
30693353-11	2019	Maximum water content was achieved more posteriorly in larger NSP nasal cavities.	Water	8-13	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	62-65
30693353-12	2019	CONCLUSIONS: High wall shear and heat and water vapor flux in posterior perforation regions may explain the crusting most commonly noted on posterior NSP edges.	Water	42-47	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	150-153
15461698-5	2004	Dr. Andreoli and his colleagues proposed a water channel mechanism for the action of ADH, which has been confirmed by the cloning and heterologous expression of aquaporin-2.	Water	43-48	aquaporin 2	Mus musculus	161-172
30926820-2	2019	As it contacts a colder material, hot water generates condensation within the cavities at the solid surface, which eventually builds bridges between the substrate and the water, and thus destroys repellency.	Water	38-43	alcohol dehydrogenase iron containing 1	Homo sapiens	34-37
30926820-4	2019	Hence, we can define two structural recipes for repelling hot water: drops on nanometric features hardly stick owing to the miniaturization of water bridges, whereas kinetics of condensation in large features is too slow to connect the liquid to the solid at impact.	Water	62-67	alcohol dehydrogenase iron containing 1	Homo sapiens	58-61
30926820-4	2019	Hence, we can define two structural recipes for repelling hot water: drops on nanometric features hardly stick owing to the miniaturization of water bridges, whereas kinetics of condensation in large features is too slow to connect the liquid to the solid at impact.	Water	143-148	alcohol dehydrogenase iron containing 1	Homo sapiens	58-61
31065474-10	2019	Our results suggest that it is better to store inhalers in places where there is easy access to tap water used for RMOG.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
31143736-1	2019	Purpose: The purpose of this study was to investigate parental knowledge and preference of tap water in a country where faucet water is fluoridated according to international standards and where the average percentage of dental caries in young children reaches up to approximately 73%.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
31143736-1	2019	Purpose: The purpose of this study was to investigate parental knowledge and preference of tap water in a country where faucet water is fluoridated according to international standards and where the average percentage of dental caries in young children reaches up to approximately 73%.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	91-94
15280386-1	2004	The first isoform of the Na+-K+-Cl- cotransporter (NKCC1), a widely distributed member of the cation-Cl- cotransporter superfamily, plays key roles in many physiological processes by regulating the ion and water content of animal cells and by sustaining electrolyte secretion across various epithelia.	Water	206-211	solute carrier family 12 member 2	Homo sapiens	51-56
31143736-9	2019	Amid revealing participants that our tap water is safe and that fluorine can prevent dental caries, 33% of parents would you use tap water due to its fluoride content.	Water	133-138	nuclear RNA export factor 1	Homo sapiens	129-132
31143736-10	2019	The study also showed that 65% of parents would allow their children to drink tap water if it is free from any toxic ingredients.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
31143736-13	2019	These data will also allow us to propose the use of tap water safely in young children in the state of Qatar while simultaneously advocating awareness of oral health.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
30942779-4	2019	A wide-range of bacterial genera were found in bottled and tap water filtrates from 0.2 mum filters, including genera housing opportunistic pathogens (e.g. Methylobacterium) and endospore formers (Paenibacillus).	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
30942779-5	2019	Two municipal tap water isolates were only distantly related to named species.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
30888004-6	2019	At longer times, the pH gradually increases for all densities and finally reaches a constant value corresponding to the non-radiolytic, pre-irradiation concentration of H3O+, due to the autoprotolysis of water.	Water	204-209	H3 clustered histone 15	Homo sapiens	169-172
30500396-0	2019	Apelin-13 ameliorates chronic water-immersion restraint stress-induced memory performance deficit through upregulation of BDNF in rats.	Water	30-35	apelin	Rattus norvegicus	0-6
15336526-1	2004	Water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis in mammals.	Water	57-62	aquaporin 2	Rattus norvegicus	27-31
30870430-2	2019	We previously reported that high water intake (HWI) reduced urine osmolality and urinary arginine vasopressin, improved renal function, and reduced the kidney/body weight ratio in PCK rats, an orthologous model of human PKD.	Water	33-38	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	180-183
31015768-12	2019	Chlorin e6 successfully incorporated onto PION@E6 was demonstrated by ultraviolet and visible absorption spectrophotometry, and PION@E6 owning excellent water solubility and stability were showed by Colloid stability test.	Water	153-158	gamma-secretase activating protein	Homo sapiens	128-135
30926832-8	2019	In summary, we propose that Slf is implied in the stabilisation of a dityrosine layer especially between the epicuticle and the procuticle that in turn constitutes an outward barrier against uncontrolled water flow.	Water	204-209	slf	Drosophila melanogaster	28-31
15336526-2	2004	Trafficking of AQP2 to the apical membrane is critical to the reabsorption of water in renal collecting ducts.	Water	78-83	aquaporin 2	Rattus norvegicus	15-19
30729695-12	2019	CONCLUSION: Taken together, these data indicate that TTP has a protective role against brain edema by reducing inflammation, apoptosis, and water content in the brain at 48 hr after cerebral hemorrhage.	Water	140-145	zinc finger protein 36	Rattus norvegicus	53-56
15499911-4	2004	The detection limits of E1, E2 and EE in river water sample were 0.2, 0.5 and 1 pg ml(-1) (ppt), respectively, in the multi-shot mode using five stir bars.	Water	47-52	small nucleolar RNA, H/ACA box 73A	Homo sapiens	24-37
31019536-9	2019	Fe was the primary water heavy metal in the order of open well > borehole > tap > spring > bottled water.	Water	19-24	general transcription factor IIE subunit 1	Homo sapiens	0-2
31019536-9	2019	Fe was the primary water heavy metal in the order of open well > borehole > tap > spring > bottled water.	Water	99-104	general transcription factor IIE subunit 1	Homo sapiens	0-2
31019536-16	2019	Conclusion: The current identified Fe is a major heavy metal in drinking water of Uganda, and boreholes were the major safest sources of drinking water identified in this study.	Water	73-78	general transcription factor IIE subunit 1	Homo sapiens	35-37
30543407-2	2019	Water splitting, or the disproportionation of H2O into energy-dense fuels, H2 and O2, is undoubtedly a promising strategy.	Water	46-49	relaxin 2	Homo sapiens	75-84
30469001-4	2019	Together, these factors may help explain varying CH photolysis in different types of waters: seawater &gt; ultrapure water &gt; tap water &gt; lake water.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	128-131
15142833-7	2004	To examine the effect of dehydration on ER-alpha expression, animals with and without lesions surrounding the anterior and ventral portion of the 3rd ventricle (AV3V) were water deprived for 48 h. Water deprivation resulted in a moderate increase in ER-alpha-ir in the SFO of sham-lesioned rats (P = 0.03) and a dramatic elevation in AV3V-lesioned animals (P &lt; 0.05).	Water	197-202	estrogen receptor 1	Rattus norvegicus	40-48
30350000-6	2019	A Poisson multivariable regression model identified an inverse association with water level lagged by 1 month (IRR = 0.10, 95% CI 0.01, 0.85, P &lt; 0.05).	Water	80-85	insulin receptor related receptor	Homo sapiens	111-114
30537651-8	2019	The major prevalent genera in biofilms were also detected in tap water, suggesting that biofilm growth or biofilm detachment caused by external environmental factors will allow the movement of biofilm clusters with higher ARB concentration and percentage into bulk water, thereby increasing the antibiotic resistance of bacteria in tap water.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
30537651-8	2019	The major prevalent genera in biofilms were also detected in tap water, suggesting that biofilm growth or biofilm detachment caused by external environmental factors will allow the movement of biofilm clusters with higher ARB concentration and percentage into bulk water, thereby increasing the antibiotic resistance of bacteria in tap water.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	332-335
30537651-8	2019	The major prevalent genera in biofilms were also detected in tap water, suggesting that biofilm growth or biofilm detachment caused by external environmental factors will allow the movement of biofilm clusters with higher ARB concentration and percentage into bulk water, thereby increasing the antibiotic resistance of bacteria in tap water.	Water	265-270	nuclear RNA export factor 1	Homo sapiens	61-64
30537651-8	2019	The major prevalent genera in biofilms were also detected in tap water, suggesting that biofilm growth or biofilm detachment caused by external environmental factors will allow the movement of biofilm clusters with higher ARB concentration and percentage into bulk water, thereby increasing the antibiotic resistance of bacteria in tap water.	Water	265-270	nuclear RNA export factor 1	Homo sapiens	61-64
30594047-4	2019	As a result of synaptic degeneration, CIP2A overexpression in astrocytes in vivo induces significant deficits in visual episodic memory detected by novel objective recognition test and spatial memory detected by Morris water maze.	Water	219-224	cell proliferation regulating inhibitor of protein phosphatase 2A	Mus musculus	38-43
30582575-1	2019	We present a device capable of combining nanofluidics and cryogenic transmission electron microscopy (cryo-TEM) to allow inspection of water-soluble samples under near-native conditions.	Water	135-140	MFT2	Homo sapiens	107-110
30681339-1	2019	We report a very significant cooperative effect of water-ammonia hydrogen bonding in their reactions with a Criegee intermediate, syn-CH3CHOO.	Water	51-56	synemin	Homo sapiens	130-133
30503709-9	2019	The other tested probe, APG-2, is nonselective for cations; this is, however, a potentially useful property because the sum [K+] + [Na+] determines the amount of intracellular water.	Water	176-181	heat shock protein family A (Hsp70) member 4	Homo sapiens	24-29
30316091-1	2019	People are exposed to chlorinated by-products (CBPs) through the consumption of cold tap water (CTW) (ingestion, inhalation, dermal contact) but also through the use of hot tap water (HTW) in such activities as showering and bathing (inhalation, dermal contact).	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
30316091-2	2019	This study focuses on the impact of residential water heating on CBP levels in tap water.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	79-82
30316092-0	2019	Spatial patterns of enzymatic activity in large water bodies: Ship-borne measurements of beta-D-glucuronidase activity as a rapid indicator of microbial water quality.	Water	48-53	inositol polyphosphate-5-phosphatase D	Homo sapiens	62-66
30316092-5	2019	We propose that this ship-borne water quality screening to be integrated into future water inventory programs as an initial or complementary tool (besides established fecal indicator parameters), due to its ability to provide near real-time spatial information on potential fecal contamination of large surface water resources and therefore being helpful to greatly reduce potential human health risks.	Water	32-37	inositol polyphosphate-5-phosphatase D	Homo sapiens	21-25
30316092-5	2019	We propose that this ship-borne water quality screening to be integrated into future water inventory programs as an initial or complementary tool (besides established fecal indicator parameters), due to its ability to provide near real-time spatial information on potential fecal contamination of large surface water resources and therefore being helpful to greatly reduce potential human health risks.	Water	85-90	inositol polyphosphate-5-phosphatase D	Homo sapiens	21-25
30672289-0	2019	Crystallographic Snapshots of the Zika Virus NS3 Helicase Help Visualize the Reactant Water Replenishment.	Water	86-91	KRAS proto-oncogene, GTPase	Homo sapiens	45-48
30672289-6	2019	Here, we report two high-resolution crystal structures of ZIKV NS3 helicase in complex with adenosine diphosphate (ADP) and Mn2+, one with the reactant water already loaded as previously observed and the other with the water molecule still in a loading state.	Water	152-157	KRAS proto-oncogene, GTPase	Homo sapiens	63-66
30672289-6	2019	Here, we report two high-resolution crystal structures of ZIKV NS3 helicase in complex with adenosine diphosphate (ADP) and Mn2+, one with the reactant water already loaded as previously observed and the other with the water molecule still in a loading state.	Water	219-224	KRAS proto-oncogene, GTPase	Homo sapiens	63-66
30672289-7	2019	These data suggest that the reactant water replenishment can occur between the release of phosphate and the release of ADP and improves the structural basis of the NS3 ATP hydrolysis cycle.	Water	37-42	KRAS proto-oncogene, GTPase	Homo sapiens	164-167
30598146-7	2019	The proposed sensing method exhibited its application in detecting Hg2+ in real water samples with satisfactory performance.	Water	80-85	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	67-70
30640328-4	2019	Complex 2, without such non-covalent interactions, was found to be the most efficient catalyst for the AAC reaction, affording up to 98% product yield after being placed for 15 min, at 125  C, in a water/acetonitrile mixture under low power (10 W) MW irradiation.	Water	198-203	glycine-N-acyltransferase	Homo sapiens	103-106
30679278-4	2019	These SHBs connect to form multibranched polymer chains (151 H2O per chain at 298 K), where branch points have 3 SHBs and termination points have 1 SHB.	Water	61-64	SH2 domain containing adaptor protein B	Homo sapiens	6-9
30627799-1	2019	A novel rhodamine-tryptamine conjugate-based fluorescent and chromogenic chemosensor (RTS) for detection of Hg2+ present in water was reported.	Water	124-129	enolase superfamily member 1	Homo sapiens	86-89
30627799-1	2019	A novel rhodamine-tryptamine conjugate-based fluorescent and chromogenic chemosensor (RTS) for detection of Hg2+ present in water was reported.	Water	124-129	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	108-111
30391910-7	2019	We test the use of this differential sensor for the selective detection of the water pollutant 17beta-estradiol in buffer and tap water.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
30391910-8	2019	Consistent detection results can be obtained with and without interferences of pH variations, and in tap water where unknown interferences are present.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
30388647-3	2019	The results showed that although the average concentration of total antibiotics in tap water was 10 ng/L, the concentrations reached hundreds or even thousands of ng/L in all the other sections, indicating antibiotics entering water system through human or pets discharge.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
30580046-3	2019	To explain the anisotropy of the spin-lattice relaxation under spin-locking in connective tissue a model which represents a tissue by a set of nanocavities containing water is used.	Water	167-172	spindlin 1	Homo sapiens	33-37
30580046-3	2019	To explain the anisotropy of the spin-lattice relaxation under spin-locking in connective tissue a model which represents a tissue by a set of nanocavities containing water is used.	Water	167-172	spindlin 1	Homo sapiens	63-67
30691002-6	2019	HPLC analysis of aflatoxins of the water-soluble fraction of kwete indicated that fermentation led to an over 1000-fold reduction of aflatoxins B1, B2, G1, and G2 spiked in the raw ingredients.	Water	35-40	anthocyanin regulatory R-S protein-like	Zea mays	144-162
29558102-1	2019	We employed a two-step strategy for preparing ultrathin graphdiyne-wrapped iron carbonate hydroxide nanosheets on nickel foam (FeCH@GDY/NF) as the efficient catalysts toward the electrical splitting water.	Water	199-204	ferrochelatase	Homo sapiens	127-131
30888509-6	2019	O(LA)8-RAP-loaded PEG-b-PLA micelles increased water solubility of RAP equivalent to 3.3 mg/ml with no signs of precipitation.	Water	47-52	LDL receptor related protein associated protein 1	Rattus norvegicus	7-10
30888509-6	2019	O(LA)8-RAP-loaded PEG-b-PLA micelles increased water solubility of RAP equivalent to 3.3 mg/ml with no signs of precipitation.	Water	47-52	LDL receptor related protein associated protein 1	Rattus norvegicus	67-70
30884819-1	2019	Many people around the globe prefer bottled water especially in developing countries, where tap water is not drinkable.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	92-95
30884819-1	2019	Many people around the globe prefer bottled water especially in developing countries, where tap water is not drinkable.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
30508728-3	2019	Tap water and saline water with 32 g/L of sodium chloride were employed as the media to generate MBs.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
30597678-10	2019	The 87 Sr/86 Sr ratios of both hair and leachate were linearly correlated with tap water.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
30870430-0	2019	Increased salt intake does not worsen the progression of renal cystic disease in high water-loaded PCK rats.	Water	86-91	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	99-102
30848371-7	2019	Graphical abstract Schematic presentation of the water-soluble nitrogen-doped carbon dots (C-dots) as a fluorescent probe for Cr6+ based on an inner filter effect.	Water	49-54	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	126-129
33117975-6	2019	With water-rich mobile phases, the retention behaviour of the TRAP analogues was dominated by enthalpic processes, consistent with the participation of strong hydrogen bonding effects, but became dominated by entropic effects with acetonitrile-rich mobile phases as the temperature was increased.	Water	5-10	TRAP	Homo sapiens	62-66
33117975-7	2019	These changes in the retention behaviour of these TRAP peptides are consistent with the generation of water or acetonitrile clusters in the mobile phase depending on the volume fractions of the organic solvent as the Sil-ODA18 stationary phase transitions from its crystalline to its isotropic state.	Water	102-107	TRAP	Homo sapiens	50-54
30448547-8	2019	Additionally, both eARG and iARG concentrations in tap water presented a seasonal pattern with most abundant prevalence in summer.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
30764612-0	2019	Evolution of Cavitation Bubble in Tap Water by Continuous-Wave Laser Focused on a Metallic Surface.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
30764612-1	2019	As an example of photon-matter interaction, we experimentally investigate the temporal evolution of a millimeter-sized cavitation bubble, induced by focusing a continuous-wave laser on a metallic plate in tap water.	Water	209-214	nuclear RNA export factor 1	Homo sapiens	205-208
30832438-5	2019	Four categories of factors affecting the risk of threat to tap water consumers were assumed: the frequency or the probability of exposure-P, financial losses-C, damages to peoples" health-HL, the degree of the security-S. Based on this, a four-parametric risk matrix was developed.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
30380445-1	2019	Carbonic anhydrase (CA) II plays major roles in pH regulation of body, protection of electrolyte balance, transportation of water and some metabolic pathways.	Water	124-129	carbonic anhydrase 2	Homo sapiens	0-26
30616062-10	2019	The AOX concentration in the synthetic water samples decreased in the following order: seawater (8.49 mg L-1) &gt; marine culture water (4.05 mg L-1) &gt; fresh water (1.89 mg L-1).	Water	39-44	acyl-CoA oxidase 1	Homo sapiens	4-7
30616062-10	2019	The AOX concentration in the synthetic water samples decreased in the following order: seawater (8.49 mg L-1) &gt; marine culture water (4.05 mg L-1) &gt; fresh water (1.89 mg L-1).	Water	90-95	acyl-CoA oxidase 1	Homo sapiens	4-7
30616062-10	2019	The AOX concentration in the synthetic water samples decreased in the following order: seawater (8.49 mg L-1) &gt; marine culture water (4.05 mg L-1) &gt; fresh water (1.89 mg L-1).	Water	90-95	acyl-CoA oxidase 1	Homo sapiens	4-7
30396682-2	2019	In this work, a combined technique for the enhanced coagulation of this surface water was proposed and investigated using cationic grafted starch (St-G) and polyaluminum chloride (PACl) as co-coagulants, followed by a magnetic ion-exchange resin (MIER).	Water	80-85	chromosome 6 open reading frame 15	Homo sapiens	147-151
30670307-4	2019	Recent studies have uncovered T helper type 17 skewing in ichthyotic skin, resembling psoriasis, and high frequencies of IL-17- and IL-22-expressing T cells in blood, correlating with severity and transepidermal water loss.	Water	212-217	interleukin 17A	Homo sapiens	121-126
30670307-4	2019	Recent studies have uncovered T helper type 17 skewing in ichthyotic skin, resembling psoriasis, and high frequencies of IL-17- and IL-22-expressing T cells in blood, correlating with severity and transepidermal water loss.	Water	212-217	interleukin 22	Homo sapiens	132-137
30469174-0	2019	Surface Characterizations of Railway Electrical Wires Coated with Anti-Icing Mixtures of Ethylene Glycol or Glycerol with Tap Water.	Water	126-131	nuclear RNA export factor 1	Homo sapiens	122-125
30469174-4	2019	In the present study, the railway contact wires are coated with anti-icing mixtures of ethylene glycol/tap water and glycerol/tap water at various ratios (v/v %) as well as with tap water alone, at temperatures of -30 and -40  C in a deep freezer.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
30469174-4	2019	In the present study, the railway contact wires are coated with anti-icing mixtures of ethylene glycol/tap water and glycerol/tap water at various ratios (v/v %) as well as with tap water alone, at temperatures of -30 and -40  C in a deep freezer.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
30469174-4	2019	In the present study, the railway contact wires are coated with anti-icing mixtures of ethylene glycol/tap water and glycerol/tap water at various ratios (v/v %) as well as with tap water alone, at temperatures of -30 and -40  C in a deep freezer.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
30469174-4	2019	In the present study, the railway contact wires are coated with anti-icing mixtures of ethylene glycol/tap water and glycerol/tap water at various ratios (v/v %) as well as with tap water alone, at temperatures of -30 and -40  C in a deep freezer.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
30469174-7	2019	Conclusively, the fragments coated with 40/60 and 60/40 (v/v %) ratios of ethylene glycol or glycerol with tap water, as compared with the uncoated fragments, are shown to have been effectively de-iced.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
30469174-8	2019	The surface-characterizations data thus indicate that mixtures of glycerol or ethylene glycol with tap water can be practical de-icing agents for application to railway contact wires.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
30649995-7	2019	Here, we show that, in vivo, this domain functions as a primary highly reversible LD targeting motif in Plin1-3, and, in vitro, we document reversible and competitive binding between a wild-type purified Plin1 11mr peptide and a mutant with reduced binding affinity to both "naked" and phospholipid-coated oil-water interfaces.	Water	310-315	perilipin 1	Homo sapiens	104-109
30649995-7	2019	Here, we show that, in vivo, this domain functions as a primary highly reversible LD targeting motif in Plin1-3, and, in vitro, we document reversible and competitive binding between a wild-type purified Plin1 11mr peptide and a mutant with reduced binding affinity to both "naked" and phospholipid-coated oil-water interfaces.	Water	310-315	perilipin 1	Homo sapiens	204-209
30703317-10	2019	As the temperature increases toward room temperature, endothermic proton transfer becomes increasingly feasible, promoting the formation of H2O   HN5 via H2O-H-N5 as an intermediate species.	Water	140-143	MT-RNR2 like 5 (pseudogene)	Homo sapiens	146-149
30721038-4	2019	In this work, we present a specific Ac(III)-H2O first-principles-based intermolecular potential, which has been developed following the exchangeable Hydrated Ion model.	Water	44-47	adenylate cyclase 3	Homo sapiens	39-42
30721038-5	2019	This potential has been used in classical molecular dynamics (MD) simulations of Ac(III) in water.	Water	92-97	adenylate cyclase 3	Homo sapiens	81-88
30721038-6	2019	Results show a well-defined Ac(III) ennea-hydrated aqua ion with a mean Ac-O distance of 2.66 +- 0.02 A, surrounded by a compact second hydration shell formed by ~20 H2O centered at 4.9 +- 0.1 A.	Water	166-169	adenylate cyclase 3	Homo sapiens	28-35
30600941-3	2019	In this work, induced CPL of [Eu(pda)2 ]- and [Eu(bda)2 ]- in water solutions containing a mixture of d- and l- amino acids were examined.	Water	62-67	transcription factor AP-2 beta	Homo sapiens	33-38
30556289-3	2019	Reported here is that the syn isomer [FeIV (Osyn )(TMC)(NCMe)]2+ (2) converts into its anti form [FeIV (Oanti )(TMC)(NCMe)]2+ (1) in MeCN, an isomerization facilitated by water and monitored most readily by 1 H NMR and Raman spectroscopy.	Water	171-176	synemin	Homo sapiens	26-29
30755622-1	2019	Endocan is a water-soluble proteoglycan exclusively secreted by vascular endothelium.	Water	13-18	endothelial cell specific molecule 1	Homo sapiens	0-7
30742785-4	2019	( b) Acid-sensing taste receptor cells (TRCs) expressing otopetrin 1 on type III presynaptic TRCs on the tongue, which were previously suggested as the sour taste sensors, also mediate taste responses to water.	Water	204-209	otopetrin 1	Homo sapiens	57-68
30133024-2	2019	Cyclodextrin, beta-1,3-glucan, lysozyme, and liposomes can stably solubilize not only C60 and C70 , but also some C60 derivatives in water.	Water	133-138	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	14-22
30336414-1	2019	The reduction of tap water consumption in all activity sectors, including the building industry, is crucial to the sustainability of water resources.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
30336414-7	2019	Mortar properties such as setting time, workability, flexural strength, compressive strength and morphology were obtained for 100% effluent and tap water/effluent mixtures (50:50) with and without ED-T pre-treatment.	Water	148-153	nuclear RNA export factor 1	Homo sapiens	144-147
30678201-3	2019	In this work, we present a renewable nanopaper for the purpose of water softening prepared from phosphorylated TEMPO-oxidized cellulose nanofibrils (PT-CNF).	Water	66-71	NPHS1 adhesion molecule, nephrin	Homo sapiens	152-155
30296047-1	2019	A water-soluble meso-carboxy aryl substituted [18] heteroannulene (porphyrin) and its Zn-complex have been found to be viable in targeting alpha-Syn aggregation at all its key microevents, namely, primary nucleation, fibril elongation, and secondary nucleation, by converting the highly heterogeneous and cytotoxic aggresome into a homogeneous population of minimally toxic off-pathway oligomers, that remained unexplored until recently.	Water	2-7	synemin	Homo sapiens	145-148
15142833-7	2004	To examine the effect of dehydration on ER-alpha expression, animals with and without lesions surrounding the anterior and ventral portion of the 3rd ventricle (AV3V) were water deprived for 48 h. Water deprivation resulted in a moderate increase in ER-alpha-ir in the SFO of sham-lesioned rats (P = 0.03) and a dramatic elevation in AV3V-lesioned animals (P &lt; 0.05).	Water	197-202	estrogen receptor 1	Rattus norvegicus	250-258
15373445-2	2004	Complementary ssDNAs dissolved in water were shown to produce the relevant double-stranded DNA (dsDNA) at a water/CCl4 interface in the presence of octadecylamine (ODA) in the oil phase, while hybridization between ssDNAs did not proceed in the water phase, as demonstrated by the fluorescence dynamics of ethidium bromide as a probe for the DNA structure.	Water	34-39	C-C motif chemokine ligand 4	Homo sapiens	114-118
30267977-2	2019	The color change and quenching of the dye emission are selective detections of picric acid at nanomolar concentration is accomplished in water medium without having any interference from other NAC"s.	Water	137-142	X-linked Kx blood group	Homo sapiens	193-196
30717425-1	2019	The CNS plasma-membrane water channel aquaporin-4 (AQP4) is expressed as two major isoforms able to aggregate into supramolecular assemblies known as "orthogonal arrays of particles" (OAPs).	Water	24-29	aquaporin 4	Homo sapiens	38-49
30717425-1	2019	The CNS plasma-membrane water channel aquaporin-4 (AQP4) is expressed as two major isoforms able to aggregate into supramolecular assemblies known as "orthogonal arrays of particles" (OAPs).	Water	24-29	aquaporin 4	Homo sapiens	51-55
30427219-0	2019	Role of PKC and AMPK in hypertonicity-stimulated water reabsorption in rat inner medullary collecting ducts.	Water	49-54	protein kinase C, gamma	Rattus norvegicus	8-11
30427219-2	2019	We investigated whether protein kinase C (PKC) and adenosine monophosphate kinase (AMPK) are involved in hypertonicity-regulated water permeability.	Water	129-134	protein kinase C, gamma	Rattus norvegicus	24-40
30497265-1	2019	The nature of the oxidizing species in water oxidation reactions with chemical oxidants catalyzed by alpha-[Fe(OTf)2(mcp)] (1alpha; mcp = N, N"-dimethyl- N, N"-bis(pyridin-2-ylmethyl)cyclohexane-1,2-diamine, OTf = trifluoromethanesulfonate anion) and beta-[Fe(OTf)2(mcp)] (1beta) has been investigated.	Water	39-44	POU class 2 homeobox 2	Homo sapiens	111-130
30497265-1	2019	The nature of the oxidizing species in water oxidation reactions with chemical oxidants catalyzed by alpha-[Fe(OTf)2(mcp)] (1alpha; mcp = N, N"-dimethyl- N, N"-bis(pyridin-2-ylmethyl)cyclohexane-1,2-diamine, OTf = trifluoromethanesulfonate anion) and beta-[Fe(OTf)2(mcp)] (1beta) has been investigated.	Water	39-44	POU class 2 homeobox 2	Homo sapiens	260-278
30427219-2	2019	We investigated whether protein kinase C (PKC) and adenosine monophosphate kinase (AMPK) are involved in hypertonicity-regulated water permeability.	Water	129-134	protein kinase C, gamma	Rattus norvegicus	42-45
15345386-6	2004	In contrast, ionizing radiation could readily inactivate MS2 in water, and there was a 3-log(10) reduction at a dose of 100 Gy, although this did not occur when the phage was diluted in high-protein-content stocks of CaCV or FeCV.	Water	64-69	MS2	Homo sapiens	57-60
30427219-4	2019	The PKC inhibitors chelerythrine (10 microM) and rottlerin (50 microM) significantly reversed the increase in osmotic water permeability stimulated by hypertonicity in perfused rat terminal IMCDs.	Water	118-123	protein kinase C, gamma	Rattus norvegicus	4-7
30427219-12	2019	In conclusion, hypertonicity regulates water reabsorption by activating PKC.	Water	39-44	protein kinase C, gamma	Rattus norvegicus	72-75
30427219-13	2019	Hypertonicity-stimulated water reabsorption by PKC may be related to the decrease in endocytosis of AQP2.	Water	25-30	protein kinase C, gamma	Rattus norvegicus	47-50
30468577-7	2019	The method is tested for a one-dimensional harmonic oscillator, pure water molecules, a Bovine pancreatic trypsin inhibitor (BPTI) protein in water molecules, and a hydrated 1,2-dispalmitoyl- sn-phosphatidylcholine (DPPC) lipid bilayer in water molecules.	Water	142-147	spleen trypsin inhibitor I	Bos taurus	125-129
15340208-0	2004	Oxidation of 3-hydroxypiperidines with iodosylbenzene in water: tandem oxidative Grob fragmentation-cyclization reaction.	Water	57-62	C-X-C motif chemokine ligand 2	Homo sapiens	81-85
30718974-11	2019	CYP1A1 and CYP1A2 expressions increased after sanguinarine-containing solution, fulvic acid, and drinking water acidifier treatment.	Water	106-111	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	11-17
30565354-6	2019	Moreover, administering EP to Abeta(1-40)-infused rats significantly improves their performance on reference, spatial performance, and working memory tests during water maze tasks; concurrent proportional decreases are also observed in malondialdehyde levels, acetylcholinesterase (AChE) activity, and Abeta accumulation levels in brain tissues.	Water	163-168	amyloid beta precursor protein	Rattus norvegicus	30-35
30367970-5	2019	Furthermore, using a radial arm water maze, the main effect was observed on working memory which was significantly impaired in Abeta-Tau group only 3 months post injections.	Water	32-37	amyloid beta precursor protein	Rattus norvegicus	127-132
15497749-3	2004	Stearylamine and cyclosporin A were dissolved in ethanol and acetone and the resultant organic solution was dropped into water at 60 degrees C. The drug-loaded SLN suspension quickly formed with an azury color.	Water	121-126	sarcolipin	Homo sapiens	160-163
30468840-4	2019	Basic AFs (AFB1, AFB2, AFG1, and AFG2) are metabolized in the liver or by microbes that produce hydroxylated metabolites (AFM1, AFM2, and AFP1) and aflatoxicol (AFL), soluble in water and easy to dispose.	Water	178-183	AFG1 like ATPase	Homo sapiens	23-27
30871359-3	2019	This study aims to observe the protection of the water extract of Lonicerae Japonicae Flos (FL) from carbon tetrachloride (CCl4)-induced liver fibrosis in mice.	Water	49-54	chemokine (C-C motif) ligand 4	Mus musculus	123-127
30508412-4	2019	The present results are the first to demonstrate that PKC/p38 MAPK signaling is involved in ANGII-induced water and sodium intake and oxytocin (OT) secretion in OVX rats.	Water	106-111	protein kinase C, alpha	Rattus norvegicus	54-57
15315464-3	2004	Molecular dynamics simulations of the preceding peptide and Ac-(AAAAK)(3)A-NH(2) in water using the potential energy parameter set CHARMM22/CMAP correctly yield an alpha-helix, in contrast to simulations with the set CHARMM22, which result in a pi-helix.	Water	84-89	cystatin F	Homo sapiens	140-144
30528006-0	2019	O3-BAC-Cl2: A multi-barrier process controlling the regrowth of opportunistic waterborne pathogens in drinking water distribution systems.	Water	78-83	endogenous retrovirus group W member 5	Homo sapiens	7-10
30528006-1	2019	Simulated drinking water distribution system (DWDS) treated with O3-BAC-Cl2 (ozone-biological activated carbon-chlorine) was constructed to study its effects on the regrowth of five typical opportunistic pathogens (OPs).	Water	19-24	endogenous retrovirus group W member 5	Homo sapiens	72-75
30528006-8	2019	O3-BAC-Cl2 could be an effective multi-barrier process to suppress the proliferation of OPs in the bulk water of DWDS.	Water	104-109	endogenous retrovirus group W member 5	Homo sapiens	7-10
30474725-3	2019	Such a technology, exploiting the special properties of hot compressed water is called hydrothermal liquefaction.	Water	71-76	alcohol dehydrogenase iron containing 1	Homo sapiens	56-59
30474728-5	2019	To enrich for methanotrophs, we designed and operated four laboratory-scale, continuously methane-fed column reactors, inoculated with filter sand and one control column fed with tap water.	Water	183-188	nuclear RNA export factor 1	Homo sapiens	179-182
15303872-3	2004	Values of pKR (KR = [ROH][H+]/[R+]) have been obtained by combining rate constants, kH, for the acid-catalyzed ionization of the alcohols with kH2O for attack of water on the carbocation measured by the azide clock method.	Water	162-167	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	10-13
30551549-1	2019	Salvianic acid A (SAA) is an active water-soluble constituent derived from Salvia miltiorrhiza Bge that is used extensively in the treatment of angiocardiopathy in China.	Water	36-41	serum amyloid A1 cluster	Homo sapiens	18-21
30519876-3	2019	ABCA1, ABCG1, and SR-B1 molecules contain 50, 19, and 13 Chol-binding motifs, respectively, that are localized either in membrane helices, or at membrane-water interface, or in water-exposed protein regions.	Water	154-159	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
30519876-3	2019	ABCA1, ABCG1, and SR-B1 molecules contain 50, 19, and 13 Chol-binding motifs, respectively, that are localized either in membrane helices, or at membrane-water interface, or in water-exposed protein regions.	Water	154-159	scavenger receptor class B member 1	Homo sapiens	18-23
30519876-3	2019	ABCA1, ABCG1, and SR-B1 molecules contain 50, 19, and 13 Chol-binding motifs, respectively, that are localized either in membrane helices, or at membrane-water interface, or in water-exposed protein regions.	Water	177-182	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
30519876-3	2019	ABCA1, ABCG1, and SR-B1 molecules contain 50, 19, and 13 Chol-binding motifs, respectively, that are localized either in membrane helices, or at membrane-water interface, or in water-exposed protein regions.	Water	177-182	scavenger receptor class B member 1	Homo sapiens	18-23
30318209-6	2019	CNF with 1.44 mmol/g carboxylate content resulted high level of water retention (13.4 g/g fiber) Cellulose nanofibers were used in cementitious mixtures.	Water	64-69	NPHS1 adhesion molecule, nephrin	Homo sapiens	0-3
15045507-4	2004	Acute cold exposure suppressed plasma leptin concentration (25 min: -14%, 60 min: -22%, P=0.0001), whilst repeated cold-water immersion was associated with an increase of plasma leptin concentration relative to test day 1 (+19% day 8, +13% day 15, overall P=0.03).	Water	120-125	leptin	Homo sapiens	178-184
30791865-4	2019	Mounting evidence has demonstrated that AQP4, a water channel protein, is closely correlated with brain edema and could be an optimal therapeutic target for the reduction of ischemic brain edema.	Water	48-53	aquaporin 4	Homo sapiens	40-44
30791865-5	2019	AQP4 is prevalently distributed in the central nervous system, and mainly regulates water flux in brain cells under normal and pathological conditions.	Water	84-89	aquaporin 4	Homo sapiens	0-4
15045507-7	2004	We therefore conclude that acute and repeated cold-water immersions have separate and opposing effects on circulating leptin concentrations in humans.	Water	51-56	leptin	Homo sapiens	118-124
15284286-9	2004	It is concluded that AE1 and SLC26A7 are differentially regulated in OMCD in water deprivation.	Water	77-82	solute carrier family 4 member 1 (Diego blood group)	Rattus norvegicus	21-24
15527074-4	2004	In order to verify this hypothesis in animal experiment, the 40% ethanol fraction of hot-water extracts was examined for its preventive effect against benzo(a)pyrene-induced tumorigenesis in the forestomach of A/J mice, given as drinking water containing the above fraction at 0.5-2.0% levels.	Water	89-94	alcohol dehydrogenase, iron containing, 1	Mus musculus	85-88
31393245-3	2019	METHODS: The water-soluble aliphatic polyester was synthesized by the solvent esterification process and characterized using viscometry, GPC, FT-IR and 1H NMR spectroscopy.	Water	13-18	glycophorin C (Gerbich blood group)	Homo sapiens	137-140
30306658-4	2019	The goal of the present study was to explore whether iNPH is associated with altered subcellular distribution of aquaporin-4 (AQP4) water channels, which is reported to facilitate CSF circulation and paravascular glymphatic drainage of metabolites from the brain parenchyma.	Water	132-137	aquaporin 4	Homo sapiens	113-124
30306658-4	2019	The goal of the present study was to explore whether iNPH is associated with altered subcellular distribution of aquaporin-4 (AQP4) water channels, which is reported to facilitate CSF circulation and paravascular glymphatic drainage of metabolites from the brain parenchyma.	Water	132-137	aquaporin 4	Homo sapiens	126-130
15527075-0	2004	Reductive effect of hot-water extracts from woody ear (Auricularia auricula-judae Quel.)	Water	24-29	alcohol dehydrogenase, iron containing, 1	Mus musculus	20-23
30306658-6	2019	Electron microscopy revealed significantly reduced density of AQP4 water channels in astrocytic endfoot membranes along cortical microvessels in patients with iNPH versus reference subjects.	Water	67-72	aquaporin 4	Homo sapiens	62-66
15276152-5	2004	In contrast, the expression of the aquaporin-4 (AQP4) (water channel) protein was only slightly altered after ischemia.	Water	55-60	aquaporin 4	Rattus norvegicus	35-46
29471549-4	2019	We found that Glud1-deficient mice have behavioral abnormalities in the 3 SCZ symptom domains, with increased baseline and amphetamine-induced hyperlocomotion as a positive symptom proxy, nest building and social preference as a negative symptom proxy, and reversal/extradimensional set shifting in the water T-maze and contextual fear conditioning as a cognitive symptom proxy.	Water	303-308	glutamate dehydrogenase 1	Mus musculus	14-19
15276152-5	2004	In contrast, the expression of the aquaporin-4 (AQP4) (water channel) protein was only slightly altered after ischemia.	Water	55-60	aquaporin 4	Rattus norvegicus	48-52
15145928-2	2004	Although relatively less efficient compared with other aquaporins, MIP is suggested to function as a water channel, as an adhesion molecule, and is required for lens transparency.	Water	101-106	major intrinsic protein of lens fiber	Rattus norvegicus	67-70
30573564-16	2018	Bortezomib combined with ICE/R in patients with relapsed/refractory HAL is feasible with response and survival comparing favorably against previously reported second-line therapies.	Water	25-28	histidine ammonia-lyase	Homo sapiens	68-71
15145942-3	2004	Cox23p is homologous to Cox17p, a water-soluble copper protein previously implicated in the maturation of the Cu(A) center of cytochrome oxidase.	Water	34-39	Cox23p	Saccharomyces cerevisiae S288C	0-6
15123721-8	2004	In intact vessels Axl was phosphorylated by H(2)O(2), and Axl phosphorylation was inhibited by warfarin treatment in balloon-injured carotids.	Water	44-49	AXL receptor tyrosine kinase	Mus musculus	18-21
30487216-6	2018	Thus, translational readthrough and Cry1 expression were conditional on the supply of ncAA via culture medium or drinking water and were restricted to neurons by synapsin-dependent expression of aminoacyl tRNA-synthetase.	Water	122-127	cryptochrome 1 (photolyase-like)	Mus musculus	36-40
15135229-1	2004	Three water channel proteins, aquaporins, have been shown to be expressed in the placentae of humans and sheep-AQP1, 3, 8; AQP1 is in the vasculature, whereas AQP3, 8 are in the trophoblast cells.	Water	6-11	aquaporin-1	Ovis aries	123-127
30511862-4	2018	The rate coefficient of the corresponding reaction, syn-CH3CHOO + CH3OH + H2O   products, has been determined to be (1.95 +- 0.11) x 10-32 cm6 s-1 at 298 K, with no observable pressure dependence for 250-755 Torr.	Water	74-77	synemin	Homo sapiens	52-55
15037626-1	2004	Arginine vasopressin (AVP) increases the water permeability of renal collecting duct principal cells by inducing the fusion of vesicles containing the water channel aquaporin-2 (AQP2) with the plasma membrane (AQP2 shuttle).	Water	41-46	aquaporin 2	Homo sapiens	151-176
30287025-2	2018	CA modified first by polyethyleneimine grafting (CAP) and then by ethylenediamine (CAPE) for enhancing Cu(II) and Pb(II) removal from water.	Water	134-139	structural maintenance of chromosomes 2	Homo sapiens	83-87
15037626-1	2004	Arginine vasopressin (AVP) increases the water permeability of renal collecting duct principal cells by inducing the fusion of vesicles containing the water channel aquaporin-2 (AQP2) with the plasma membrane (AQP2 shuttle).	Water	41-46	aquaporin 2	Homo sapiens	178-182
15025557-2	2004	The catalytic constant decreased in all substrates as the molar fraction of deuterated water in the medium increased, while the catalytic affinity only decreased for the o-diphenols with an R group in C-1 [-H, -CH3 and -CH(CH3)2].	Water	87-92	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	201-204
30089212-2	2018	In this study, via using the lipid bilayer as a soft substrate to accommodate the duplex oligonucleotide, the structure of the water layer surrounding the oligonucleotide was detected under the perturbation of the calcium ions (Ca2+) with chiral and achiral sum frequency generation (SFG) vibrational spectroscopy.	Water	127-132	carbonic anhydrase 2	Homo sapiens	228-231
30089212-3	2018	With increasing Ca2+ concentration, both the chiral and achiral water vibrational signals had similar concentration-dependent changes, i.e., an initial decreasing phase followed by an increasing phase.	Water	64-69	carbonic anhydrase 2	Homo sapiens	16-19
15158974-4	2004	The most popular member of these type of polymers is poly(N-isopropylacrylamide) (poly(NIPA)) which exhibits temperature-sensitive character, in which the polymer chains change from water-soluble coils to water-insoluble globules in aqueous solution as temperature increases above the lower critical solution temperature (LCST) of the polymer.	Water	182-187	zinc finger C3HC-type containing 1	Homo sapiens	87-91
30522523-5	2018	In addition to hygiene and dietary habits, we found that the composition of tap water was related to important changes in the abundance of several bacterial genera.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
30563245-5	2018	Moreover, the extent application of this simple assay was successfully demonstrated in tap water samples with high reliability and applicability, indicating remarkable application in real samples.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
15158974-4	2004	The most popular member of these type of polymers is poly(N-isopropylacrylamide) (poly(NIPA)) which exhibits temperature-sensitive character, in which the polymer chains change from water-soluble coils to water-insoluble globules in aqueous solution as temperature increases above the lower critical solution temperature (LCST) of the polymer.	Water	205-210	zinc finger C3HC-type containing 1	Homo sapiens	87-91
15158758-8	2004	Displacement from a trioctanoin-water interface of active HPL by an inactive mutant (S152G) was studied in the presence of bile salts by measuring HPL distribution between the water phase and the oil-water interface.	Water	32-37	galectin 1	Homo sapiens	58-61
15158758-8	2004	Displacement from a trioctanoin-water interface of active HPL by an inactive mutant (S152G) was studied in the presence of bile salts by measuring HPL distribution between the water phase and the oil-water interface.	Water	176-181	galectin 1	Homo sapiens	58-61
15158758-8	2004	Displacement from a trioctanoin-water interface of active HPL by an inactive mutant (S152G) was studied in the presence of bile salts by measuring HPL distribution between the water phase and the oil-water interface.	Water	176-181	galectin 1	Homo sapiens	58-61
30429099-2	2018	The principal obstacles to clinical development of MMP-12 inhibitors are an inadequate selectivity for the target enzyme and a poor water solubility, with consequent poor oral bioavailability.	Water	132-137	matrix metallopeptidase 12	Homo sapiens	51-57
30429099-3	2018	We recently reported a new class of sugar-based arylsulfonamide carboxylates with a nanomolar activity for MMP-12, a good selectivity and an improved water solubility.	Water	150-155	matrix metallopeptidase 12	Homo sapiens	107-113
15158758-9	2004	Colipase was limiting for HPL binding to the oil-water interface (colipase to lipase molar ratio: 0.5) and, thus, for lipolysis.	Water	49-54	galectin 1	Homo sapiens	26-29
15158758-10	2004	Upon adding S152G, which has the same affinity for colipase, inactive and active HPL were found to compete for binding at the oil-water interface.	Water	130-135	galectin 1	Homo sapiens	81-84
15158758-11	2004	When equal amounts of HPL and HPL S152G were used, the lipolysis rate dropped to half the maximum rate recorded with HPL alone, suggesting that half the active HPL was rapidly desorbed from the oil-water interface.	Water	198-203	galectin 1	Homo sapiens	22-25
30243381-1	2018	Catalase catalyzes the decomposition of hydrogen peroxide to water and oxygen.	Water	61-66	AKO65_RS18850	Bacillus pumilus	0-8
15158758-11	2004	When equal amounts of HPL and HPL S152G were used, the lipolysis rate dropped to half the maximum rate recorded with HPL alone, suggesting that half the active HPL was rapidly desorbed from the oil-water interface.	Water	198-203	galectin 1	Homo sapiens	30-33
15158758-11	2004	When equal amounts of HPL and HPL S152G were used, the lipolysis rate dropped to half the maximum rate recorded with HPL alone, suggesting that half the active HPL was rapidly desorbed from the oil-water interface.	Water	198-203	galectin 1	Homo sapiens	30-33
15158758-11	2004	When equal amounts of HPL and HPL S152G were used, the lipolysis rate dropped to half the maximum rate recorded with HPL alone, suggesting that half the active HPL was rapidly desorbed from the oil-water interface.	Water	198-203	galectin 1	Homo sapiens	30-33
30336121-0	2018	Identification of free-living amoebae isolated from tap water in Istanbul, Turkey.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
15099568-3	2004	Using 2D-NMR and circular dichroism spectroscopy we demonstrated that GALP does not adopt a preferred conformation in pure water alone.	Water	123-128	galanin like peptide	Homo sapiens	70-74
30336121-10	2018	With this study, we established Acanthamoeba genotype T4 and Vermamoeba vermiformis as contaminants of tap water in Istanbul.	Water	107-112	nuclear RNA export factor 1	Homo sapiens	103-106
28422353-3	2019	The standard procedure of rinsing impressions under tap water immediately after removal from the mouth eliminates microorganisms along with saliva and blood.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
15028717-9	2004	We speculate that binding and helix folding of alphaS depends on the presence of defect structures in the membrane-water interface, which in turn results in lipid ordering in the highly curved vesicular membranes.	Water	115-120	synuclein alpha	Homo sapiens	47-53
30461017-0	2019	LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana.	Water	97-102	LSD1 zinc finger family protein	Arabidopsis thaliana	0-4
30461017-0	2019	LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana.	Water	97-102	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	7-11
30461017-0	2019	LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana.	Water	97-102	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	17-21
15075200-9	2004	In conclusion, metabolic acidosis upregulates the expression levels of AQP-2 and increases urine osmolality, suggesting an adaptive increase in water reabsorption in the collecting duct.	Water	144-149	aquaporin 2	Rattus norvegicus	71-76
30308921-7	2019	The results showed that the exposure patterns of phthalates varied among the population groups with different water intakes, and the health risk was higher for people ingesting the boiled tap water than that of the groups consuming bottled water (purified water) and filtered water with filter cartridge containing activated carbon.	Water	192-197	nuclear RNA export factor 1	Homo sapiens	188-191
30308921-7	2019	The results showed that the exposure patterns of phthalates varied among the population groups with different water intakes, and the health risk was higher for people ingesting the boiled tap water than that of the groups consuming bottled water (purified water) and filtered water with filter cartridge containing activated carbon.	Water	192-197	nuclear RNA export factor 1	Homo sapiens	188-191
30308921-7	2019	The results showed that the exposure patterns of phthalates varied among the population groups with different water intakes, and the health risk was higher for people ingesting the boiled tap water than that of the groups consuming bottled water (purified water) and filtered water with filter cartridge containing activated carbon.	Water	192-197	nuclear RNA export factor 1	Homo sapiens	188-191
30308921-7	2019	The results showed that the exposure patterns of phthalates varied among the population groups with different water intakes, and the health risk was higher for people ingesting the boiled tap water than that of the groups consuming bottled water (purified water) and filtered water with filter cartridge containing activated carbon.	Water	192-197	nuclear RNA export factor 1	Homo sapiens	188-191
15202564-5	2004	Since PEP conjugates have amphiphilic characteristics in aqueous solution, polymeric nanoparticles of PEP conjugates were prepared using a simple dialysis method in water.	Water	165-170	progestagen associated endometrial protein	Homo sapiens	102-105
31119215-13	2019	We observed that a target residual of 1 mg Cl2/L, in our system, maintained the TCC below the concentration found in Zurich drinking water.	Water	133-138	endogenous retrovirus group W member 5	Homo sapiens	43-48
30761004-2	2019	Soluble epoxide hydrolases (sEH), enzymes present in all living organisms, metabolize epoxy fatty acids (EpFAs) to corresponding 1,2-diols by the addition of a molecule of water.	Water	172-177	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-26
30761004-2	2019	Soluble epoxide hydrolases (sEH), enzymes present in all living organisms, metabolize epoxy fatty acids (EpFAs) to corresponding 1,2-diols by the addition of a molecule of water.	Water	172-177	epoxide hydrolase 2, cytoplasmic	Mus musculus	28-31
15033922-4	2004	Moreover, increased Abeta production also coincided with increased AD-type amyloid plaque burden in the brain and impaired performance in a spatial water maze task.	Water	148-153	amyloid beta (A4) precursor protein	Mus musculus	20-25
30656293-4	2019	The H+ and the lone pair do not stay alone to move or shuttle freely between adjacent H2O molecules, but they are attached to a H2O molecule to form (H3O+ and OH-) 4H2O tetrahedral motifs, which transits an O:H-O bond into the H H anti-HB point breaker in acidic solutions and into the O: :O super-HB compressor and polarizer in basic solutions, respectively.	Water	86-89	H3 clustered histone 15	Homo sapiens	150-153
30656293-4	2019	The H+ and the lone pair do not stay alone to move or shuttle freely between adjacent H2O molecules, but they are attached to a H2O molecule to form (H3O+ and OH-) 4H2O tetrahedral motifs, which transits an O:H-O bond into the H H anti-HB point breaker in acidic solutions and into the O: :O super-HB compressor and polarizer in basic solutions, respectively.	Water	128-131	H3 clustered histone 15	Homo sapiens	150-153
15100356-4	2004	Fluorescence-based real-time reverse transcription-PCR and Northern blot analysis showed upregulation of the UT-A2 urea transporter and the aquaporin 2 (AQP2) and AQP3 water channel transcripts but no change in other urea transporters or AQP.	Water	168-173	aquaporin 2	Mus musculus	140-151
15366423-4	2004	Of the single-tryptophan P178 mutants studied, W460 showed the highest sensitivity to NBS treatment, pointing to the importance of the water-exposed Trp460 in colicin channel activity.	Water	135-140	nibrin	Homo sapiens	86-89
30584762-2	2019	We have approached this challenge by utilizing the classical molecular dynamics simulations technique to gain visual appreciation of the vapor/liquid and liquid/liquid interface between tri- n-butyl phosphate (TBP) and n-dodecane with air and water.	Water	243-248	TATA-box binding protein	Homo sapiens	210-213
30584762-5	2019	Through this study, we gained atomistic understanding of the behaviors of TBP and n-dodecane at the interface against air and water, useful in further computational studies of such systems.	Water	126-131	TATA-box binding protein	Homo sapiens	74-77
30604973-2	2019	It was found that in the gas phase and in water solution the most stable is the syn-conformer of the 6-keto tautomer followed by its anti-conformer and syn-conformer of the 6-enol form.	Water	42-47	synemin	Homo sapiens	80-83
30604973-2	2019	It was found that in the gas phase and in water solution the most stable is the syn-conformer of the 6-keto tautomer followed by its anti-conformer and syn-conformer of the 6-enol form.	Water	42-47	synemin	Homo sapiens	152-155
30604973-4	2019	However, in water solution the syn-conformer of the keto tautomer is 99.9%.	Water	12-17	synemin	Homo sapiens	31-34
14722776-6	2004	8-( p-Chlorophenylthio)-cGMP (8-pCPT-cGMP, 25 or 50 micro M), a membrane-permeable cGMP analogue specific for cGMP-dependent protein kinase (PKG), inhibited, whereas 2 micro M KT-5823, an inhibitor of PKG, significantly stimulated the increase of water flow induced by AVT.	Water	247-252	protein kinase cGMP-dependent 1	Homo sapiens	141-144
30646866-12	2019	Hemopexin up-regulated HO-1 protein expression, the average vessel density in the penumbra hippocampus and the VE- cadherin expression but decreased the permeability of EB, the water content of brain tissue and the ratio of Ang1/Ang2.	Water	177-182	hemopexin	Rattus norvegicus	0-9
14722776-10	2004	NO inhibits the AVT-induced increase of water flow at least partly by activation of PKG, which interferes with the hydroosmotic effect of AVT probably at (a) post-cAMP step(s).	Water	40-45	protein kinase cGMP-dependent 1	Homo sapiens	84-87
30227379-3	2019	After the superhydrophilic fabric is wetted by water in advance, hot alkaline water can be removed from the light oil/water mixture driven by gravity.	Water	78-83	alcohol dehydrogenase iron containing 1	Homo sapiens	65-68
30227379-4	2019	Also, heavy oil can be removed from the heavy oil/hot alkaline water mixture under the action of gravity using superhydrophobic fabric.	Water	63-68	alcohol dehydrogenase iron containing 1	Homo sapiens	50-53
15072787-7	2004	The higher ratio of ethanol/water gave a longer lag time prior to drug release.	Water	28-33	stathmin 1	Homo sapiens	48-51
30227379-5	2019	The separation efficiencies of the two fabrics for different mixtures of hot alkaline water and light or heavy oil are more than 95.8%.	Water	86-91	alcohol dehydrogenase iron containing 1	Homo sapiens	73-76
30227379-7	2019	The device can continuously separate oil and water at the same time from oil/hot alkaline water mixture via one-step route with high separation efficiency without consideration of the density of the oil.	Water	45-50	alcohol dehydrogenase iron containing 1	Homo sapiens	77-80
30348412-7	2019	UV-Vis spectrophotometry showed that the sensor has the limit of detection (LOD) value of as low as 4 nmol L-1 which was below the safety level of Hg2+ions (10 nmol L-1) in drinking water.	Water	182-187	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	147-150
15072787-9	2004	Lag time is inversely correlated with HPMC concentration in ethanol/water (5:1) cosolvent.	Water	68-73	stathmin 1	Homo sapiens	0-3
30468577-7	2019	The method is tested for a one-dimensional harmonic oscillator, pure water molecules, a Bovine pancreatic trypsin inhibitor (BPTI) protein in water molecules, and a hydrated 1,2-dispalmitoyl- sn-phosphatidylcholine (DPPC) lipid bilayer in water molecules.	Water	142-147	spleen trypsin inhibitor I	Bos taurus	88-123
30468577-7	2019	The method is tested for a one-dimensional harmonic oscillator, pure water molecules, a Bovine pancreatic trypsin inhibitor (BPTI) protein in water molecules, and a hydrated 1,2-dispalmitoyl- sn-phosphatidylcholine (DPPC) lipid bilayer in water molecules.	Water	142-147	spleen trypsin inhibitor I	Bos taurus	125-129
15072787-14	2004	The release behavior and lag time could be controlled by coating conditions such as HPMC concentration, ethanol/water ratio as a coating solvent, coating level and swelling (mixing) time of coating solution.	Water	112-117	stathmin 1	Homo sapiens	25-28
30468577-7	2019	The method is tested for a one-dimensional harmonic oscillator, pure water molecules, a Bovine pancreatic trypsin inhibitor (BPTI) protein in water molecules, and a hydrated 1,2-dispalmitoyl- sn-phosphatidylcholine (DPPC) lipid bilayer in water molecules.	Water	142-147	spleen trypsin inhibitor I	Bos taurus	88-123
14752105-8	2004	The activated TGase 2 catalyzed the formation of water-insoluble dimers or polymers of alphaB-crystallin, betaB(2)-crystallin, and vimentin in HLE-B3 cells, providing evidence that TGase 2 may play a role in cataractogenesis.	Water	49-54	vimentin	Homo sapiens	131-139
30821496-5	2019	DNA LBL coatings reduced inorganic fouling from tap water by 90% when incubated statically or under flow conditions mimicking surfaces in heat exchangers.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
31686572-5	2019	Although the sparse knowledge on the ecology and physiology of Betaproteobacteria thriving in tap or bottled natural mineral/spring drinking water (DW) is an evidence of this review, it is demonstrated that DW holds a high diversity of Betaproteobacteria, whose presence may not be innocuous.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	65-68
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Water	226-231	nei like DNA glycosylase 1	Homo sapiens	77-83
30907314-9	2019	The expression levels of p- JAK2/JAK2, p-STAT3/STAT3 were upregulated in the hydrogen-rich water group compared with the control group, and p-STAT1/STAT1 was downregulated in the hydrogen-rich water group compared with the control group.	Water	91-96	Janus kinase 2	Rattus norvegicus	28-32
30907314-11	2019	CONCLUSION: Hydrogen-rich water may inhibit the apoptosis of cardiomyocytes after ischaemia-reperfusion by upregulating the expression of the JAK2-STAT3 signalling pathway, which reduces ischaemia-reperfusion injury.	Water	26-31	Janus kinase 2	Rattus norvegicus	142-146
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Water	226-231	8-oxoguanine DNA glycosylase	Homo sapiens	97-102
15090052-7	2004	However, the good correlation between alterations in ADC and AQP4 immunostaining suggests that changes in the AQP4 are involved in some of the early changes in brain water distribution observed in hypoxia-ischemia, and supports the speculation that AQP4 is involved in the transport of water across the perivascular membranes into the vascular lumen.	Water	166-171	aquaporin 4	Rattus norvegicus	61-65
30366297-5	2019	Water-soluble inorganic ions and carbonaceous components were major chemical species in PM1.0 and PM2.5, accounting for 48.9%-54.1% and 25.6%-27.8% in PM1.0, 48.1%-52.3% and 22.7%-24.7% in PM2.5.	Water	0-5	transmembrane protein 11	Homo sapiens	88-91
30366297-5	2019	Water-soluble inorganic ions and carbonaceous components were major chemical species in PM1.0 and PM2.5, accounting for 48.9%-54.1% and 25.6%-27.8% in PM1.0, 48.1%-52.3% and 22.7%-24.7% in PM2.5.	Water	0-5	transmembrane protein 11	Homo sapiens	151-154
15090052-7	2004	However, the good correlation between alterations in ADC and AQP4 immunostaining suggests that changes in the AQP4 are involved in some of the early changes in brain water distribution observed in hypoxia-ischemia, and supports the speculation that AQP4 is involved in the transport of water across the perivascular membranes into the vascular lumen.	Water	166-171	aquaporin 4	Rattus norvegicus	110-114
31364530-5	2019	A 1:1 case-control study conducted and showed that tap water consumption significantly associated with developing symptoms of gastroenteritis (odds ratio = 36.9, P = 0.018).	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
15090052-7	2004	However, the good correlation between alterations in ADC and AQP4 immunostaining suggests that changes in the AQP4 are involved in some of the early changes in brain water distribution observed in hypoxia-ischemia, and supports the speculation that AQP4 is involved in the transport of water across the perivascular membranes into the vascular lumen.	Water	166-171	aquaporin 4	Rattus norvegicus	110-114
15090052-7	2004	However, the good correlation between alterations in ADC and AQP4 immunostaining suggests that changes in the AQP4 are involved in some of the early changes in brain water distribution observed in hypoxia-ischemia, and supports the speculation that AQP4 is involved in the transport of water across the perivascular membranes into the vascular lumen.	Water	286-291	aquaporin 4	Rattus norvegicus	110-114
15090052-7	2004	However, the good correlation between alterations in ADC and AQP4 immunostaining suggests that changes in the AQP4 are involved in some of the early changes in brain water distribution observed in hypoxia-ischemia, and supports the speculation that AQP4 is involved in the transport of water across the perivascular membranes into the vascular lumen.	Water	286-291	aquaporin 4	Rattus norvegicus	110-114
32362310-5	2019	EAU was induced in mouse strain C57BL/6J by interphotoreceptor retinoid- binding protein in complete Freund"s adjuvant and pertussis toxin.	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	44-88
30144427-15	2018	Maintenance of apical CFTR might exacerbate water loss by active secretion of chloride into the intestinal lumen.	Water	44-49	cystic fibrosis transmembrane conductance regulator	Mus musculus	22-26
15030229-2	2004	In contrast, the mildly proteolyzed myoglobin had a strongly enhanced prooxidative effect on lipid oxidation in an oil in water methyl linoleate emulsion compared to native metmyoglobin, as evidenced by rates of oxygen depletion.	Water	122-127	myoglobin	Homo sapiens	36-45
30503491-6	2018	Estimated time weighted maximum water concentrations were &gt;150 pg Q1 and 60 pg 2"-MeO-BDE 68 per L seawater.	Water	32-37	homeobox D13	Homo sapiens	89-92
31037992-3	2019	The aim of this research is to investigate the frequency of endocrine disruptors and anthropogenic activity markers in a Water Supply System (SAA) in Sergipe State, Brazil.	Water	121-126	serum amyloid A1 cluster	Homo sapiens	142-145
15013706-5	2004	DNA damage-associated frequencies of translocations after exposure to hydrogen peroxide (H(2)O(2)), bleomycin, phleomycin, cisplatin, and camptothecin are higher in the rad9 diploid than in wild type.	Water	89-94	chromatin-binding protein RAD9	Saccharomyces cerevisiae S288C	169-173
30031789-9	2019	Progesterone also reduced the expression of aquaporin 4 (AQP4), the water channel involved in both edema formation and resorption.	Water	68-73	aquaporin 4	Mus musculus	44-55
30031789-9	2019	Progesterone also reduced the expression of aquaporin 4 (AQP4), the water channel involved in both edema formation and resorption.	Water	68-73	aquaporin 4	Mus musculus	57-61
30236469-5	2018	Upon the addition of BDE 47 and BDE 209, the zeta (zeta) potential of TiO2 NP increased in magnitude in artificial waters and in natural waters (river water and wastewater), but the magnitude of influence on the NP"s surface charge was specific to each natural water considered.	Water	115-120	homeobox D13	Homo sapiens	21-24
30236469-5	2018	Upon the addition of BDE 47 and BDE 209, the zeta (zeta) potential of TiO2 NP increased in magnitude in artificial waters and in natural waters (river water and wastewater), but the magnitude of influence on the NP"s surface charge was specific to each natural water considered.	Water	115-120	homeobox D13	Homo sapiens	32-35
15023080-0	2004	Role of protein-water interactions and electrostatics in alpha-synuclein fibril formation.	Water	16-21	synuclein alpha	Homo sapiens	57-72
30290983-2	2018	Glucomannan powder, a dietary fiber supplement, can be mixed with tap water to form a gel that may be a field-expedient substitute for USTG.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
30577408-10	2019	Of all analyses only bladder compliance 5 ml/cm H2O or less vs greater than 5 ml/cm H2O at postoperative urodynamics was associated with statistically increased urine brain-derived neurotrophic factor levels, suggesting that increased urine brain-derived neurotrophic factor predicts treatment failure.	Water	48-51	brain derived neurotrophic factor	Homo sapiens	167-200
30577408-10	2019	Of all analyses only bladder compliance 5 ml/cm H2O or less vs greater than 5 ml/cm H2O at postoperative urodynamics was associated with statistically increased urine brain-derived neurotrophic factor levels, suggesting that increased urine brain-derived neurotrophic factor predicts treatment failure.	Water	84-87	brain derived neurotrophic factor	Homo sapiens	167-200
15023080-7	2004	Moderate concentrations of anions affected both the rates of nucleation and the elongation of alpha-synuclein fibrillation, primarily via their effect on the interaction of the protein with water.	Water	190-195	synuclein alpha	Homo sapiens	94-109
30273770-7	2018	The results of the analysis of popular posts identified innovative ways some water businesses are using Facebook posts to promote the health benefits of tap water consumption, water conservation behaviours and responsible wastewater practices.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	153-156
15028779-4	2004	In the present work, we show that the OCT3 transporter is found throughout the brain and highly expressed in regions regulating fluid exchange, including circumventricular organs such as area postrema and subfornical organ (SFO), and in other structures implicated in the sensing of changes in blood osmolarity and regulation of salt and water ingestion.	Water	338-343	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	38-42
30680174-5	2019	Similarly, in insulin-resistant HepG2 cells, all extracts enhanced the glucose uptake and reduced the expression of PTP1B in a concentration-dependent manner, water extract displaying better activity.	Water	159-164	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	116-121
30546348-4	2018	Redundancy analysis showed that environmental factors (OTC, H2O, SOM, and pH) were the dominant factors that influence the distribution of ARGs and intI1.	Water	60-63	serpin family A member 2 (gene/pseudogene)	Homo sapiens	139-143
14993804-9	2004	Taken together, butein ameliorates renal concentrating ability via up-regulation of renal AQP 2 water channel in rats with cisplatin-induced ARF without ameliorating effect on renal filtration defect.	Water	96-101	aquaporin 2	Rattus norvegicus	90-95
30645217-1	2018	We have modeled the white water wake of a ship as a single layer of bubbles packed on the sea surface within the perimeter of the trailing turbulent wake.	Water	26-31	inositol polyphosphate-5-phosphatase D	Homo sapiens	42-46
15132331-1	2004	This study describes a fast activated carbon fiber-solid phase microextraction (ACF-SPME) method for determining organochlorine pesticides (OCPs) in water.	Water	149-154	ACF	Homo sapiens	80-83
30283993-5	2018	However, long-term application of this water for crop production could build up a significant amount of trace metals in both soil and sediments.	Water	39-44	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	49-53
30477133-3	2018	This work presents an aging of 11 pH electrodes within approximately 600 days in tap water.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
30477133-10	2018	As a result of this work, a model of the aging process of pH electrodes in tap water can be constructed and subsequently, the measurement accuracy in the periods between calibrations can be improved.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
15132331-7	2004	The results have demonstrated the suitability of the ACF-SPME-GC-MS approach for the analysis of multi-residue OCPs in water.	Water	119-124	ACF	Homo sapiens	53-56
15198039-0	2004	[Methane content in bottom sediments and water mass of the Black Sea].	Water	41-46	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	65-68
30453672-1	2018	Glutathione peroxidase 1 (GPX1) is an extensively studied selenium-dependent protein that reduces hydrogen and lipid peroxides to water.	Water	130-135	glutathione peroxidase 1	Homo sapiens	0-24
30453672-1	2018	Glutathione peroxidase 1 (GPX1) is an extensively studied selenium-dependent protein that reduces hydrogen and lipid peroxides to water.	Water	130-135	glutathione peroxidase 1	Homo sapiens	26-30
30899312-5	2018	Although Set Plus is disposable, the patient reused the product by cleansing with tap water.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
30195162-3	2018	The study was conducted at ambient temperature and LFL was fed to the bioreactor in gradually increasing concentration mixed with tap water (from 20% to 100%).	Water	134-139	nuclear RNA export factor 1	Homo sapiens	130-133
15198039-6	2004	In certain deep-sea regions, peaks of methane content in the 1000-1200 m horizons of the water column were revealed, which were most probably due to local influx of abyssal waters enriched with this gas.	Water	89-94	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	16-19
15198039-6	2004	In certain deep-sea regions, peaks of methane content in the 1000-1200 m horizons of the water column were revealed, which were most probably due to local influx of abyssal waters enriched with this gas.	Water	173-179	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	16-19
30239222-2	2018	Water enters the intercellular space of the brain primarily through aquaporin-4 (AQP-4) water channels, the main component of the glymphatic system, whereas acetazolamide, pharmacological agent used in the prevention of HACE, is the blocker of the AQP-4 molecule.	Water	0-5	aquaporin 4	Homo sapiens	68-79
30413709-4	2018	The structure of the endothelin-3-bound receptor reveals that the disruption of water-mediated interactions between W6.48 and D2.50 is critical for receptor activation, while these hydrogen-bonding interactions are partially preserved in the IRL1620-bound structure.	Water	80-85	endothelin 3	Homo sapiens	21-33
30239222-2	2018	Water enters the intercellular space of the brain primarily through aquaporin-4 (AQP-4) water channels, the main component of the glymphatic system, whereas acetazolamide, pharmacological agent used in the prevention of HACE, is the blocker of the AQP-4 molecule.	Water	0-5	aquaporin 4	Homo sapiens	81-86
15016538-1	2004	Odor analyses experiments indicated that, for the concentrations and temperatures tested, odor intensity was a function of both aqueous concentration and water temperature for water containing 1-butanol, free available chlorine, geosmin, n-hexanal, 2-methylisoborneol, and trans-2, cis-6 nonadienal.	Water	176-181	suppressor of cytokine signaling 5	Homo sapiens	282-287
30239222-2	2018	Water enters the intercellular space of the brain primarily through aquaporin-4 (AQP-4) water channels, the main component of the glymphatic system, whereas acetazolamide, pharmacological agent used in the prevention of HACE, is the blocker of the AQP-4 molecule.	Water	0-5	aquaporin 4	Homo sapiens	248-253
30405071-9	2018	The water and ethanol FZ extracts exert cardiotoxic effects via activating the PI3K/Akt/mTOR signaling pathway to induce cardiomyocyte apoptosis.	Water	4-9	mechanistic target of rapamycin kinase	Rattus norvegicus	88-92
14660656-4	2004	Anomalous UVRR enhancement of amide bands at 229 nm results from gel structure, as demonstrated by increased amide absorption at the red edge for tau 2-19 gel and implies the involvement of water in gel structure.	Water	190-195	microtubule associated protein tau	Homo sapiens	146-149
30252454-5	2018	Therefore, enhanced stability of lead phosphate particles was observed, suggesting that although addition of excess phosphate can lower the dissolved lead concentrations in tap water, it may increase concentrations of particulate lead.	Water	177-182	nuclear RNA export factor 1	Homo sapiens	173-176
29697009-0	2018	Factors associated with drinking and being satisfied with tap water in Indigenous communities in Saskatchewan, Canada.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
29697009-1	2018	Previous studies have described concerns regarding tap water in Indigenous communities, yet there is little information on participants who report drinking their tap water and being satisfied with its quality.	Water	166-171	nuclear RNA export factor 1	Homo sapiens	162-165
29697009-4	2018	Less than one-quarter of participants (23.4%) drank tap water and were satisfied with its quality.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
31949662-0	2018	MicroRNA-23b attenuates the H2O2-induced injury of microglial cells via TAB3/NF-kappaB signaling pathway.	Water	28-32	microRNA 23b	Mus musculus	0-12
30109916-6	2018	The Nb2 O5 surface also shows larger tolerance to methylamine and water molecules than Al2 O3 and TiO2 surfaces.	Water	66-71	contactin 5	Homo sapiens	4-7
14660656-5	2004	In aged, dehydrated tau 2-19 gel, proline carbonyls lose their bonds to water and tyrosine becomes deprotonated, as demonstrated by UVRR spectroscopy.	Water	72-77	microtubule associated protein tau	Homo sapiens	20-23
31949662-13	2018	Subsequently, treatment of BV-2 cells with H2O2 decreased the levels of miR-23b and activated NF-kappaB pathway in a dose dependent manner.	Water	43-47	microRNA 23b	Mus musculus	72-79
31949662-14	2018	Furthermore, overexpression of miR-23b inhibited the BV-2 apoptosis and NF-kappaB activation, while miR-23b inhibition enhanced the apoptosis and NF-kappaB activation induced by H2O2.	Water	178-182	microRNA 23b	Mus musculus	100-107
14660656-8	2004	One implication of this assignment is that the fibrillation of hydrophilic tau is thermodynamically driven by the entropy gained as hydrogen-bonded water is freed, as for collagen I.	Water	148-153	microtubule associated protein tau	Homo sapiens	75-78
18969305-1	2004	Several derivatization procedures with o-phthaldialdehyde-N-acetylcysteine (OPA-NAC) were compared for a rapid analysis of primary aliphatic short-chain monoamines in water samples by HPLC using a LiChorospher analytical separation column (100RP(18)125 mm x4 mm i.d., 5mum).	Water	167-172	synuclein alpha	Homo sapiens	80-83
30318924-8	2018	The CO2 production (RCO2) was calculated from the 2H and 18O enrichments in breath water and plasma over 5 days.	Water	83-88	gasdermin A3	Mus musculus	20-24
30585268-4	2018	Here, we showed that SRC-3-/- mice were more susceptible to dextran sulfate sodium (DSS)-induced colitis compared with wild-type mice after oral administration of 2% DSS dissolved in drinking water.	Water	192-197	nuclear receptor coactivator 3	Mus musculus	21-26
22064147-8	2004	The strong shift in water properties around 43  C is suggested to be a result of myosin denaturation, and thus the results imply differences in myosin denaturation in meat from RN-carriers compared with meat from non-carriers.	Water	20-25	myosin heavy chain 14	Homo sapiens	81-87
30058211-6	2018	We found that the amount of TA/EGCG bound to elastin was in a time-dependent pattern and this reaction showed better efficiency in acidic condition and ethanol-water mixed solvents.	Water	160-165	elastin	Homo sapiens	45-52
30240071-7	2018	Very impressively, the PVA/PAANa hydrogel can easily distinguish tap water from deionized water, and its detection limit of metal cations can be as low as 10-4  mol L-1 .	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
14593099-1	2004	Aquaporin-2 (AQP2) is a pore-forming protein that is required for regulated reabsorption of water from urine.	Water	92-97	aquaporin 2	Homo sapiens	0-11
32454667-3	2018	Acetone-water containing HPMC K-15, PEG-6000, PVP K-30 was used as the crystallization medium.	Water	8-13	keratin 15	Homo sapiens	30-34
30226536-9	2018	BI-1 overexpression in the SAH model improved neurological scores and decreased the brain water content, BBB permeability and levels of apoptosis compared with the control and sham groups following SAH.	Water	90-95	transmembrane BAX inhibitor motif containing 6	Rattus norvegicus	0-4
14593099-1	2004	Aquaporin-2 (AQP2) is a pore-forming protein that is required for regulated reabsorption of water from urine.	Water	92-97	aquaporin 2	Homo sapiens	13-17
14704269-1	2004	The binding site of the dopamine D(2) receptor (D2R), like those of homologous rhodopsin-like G protein-coupled receptors (GPCRs) that bind small molecules, is contained within a water-accessible crevice formed among its seven transmembrane segments (TMs).	Water	179-184	rhodopsin	Bos taurus	79-88
29857026-9	2018	FINDINGS: A total of 139 clinical specimens of P. aeruginosa and 19 tap water samples were analysed.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
29857026-12	2018	Surprisingly, tap water was colonized with a single PA-OprD strain during both periods, but this single clone has never been isolated from clinical specimens.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
30230050-0	2018	Corroles at the Real Solid-Liquid Interface: In Situ STM Investigation of a Water-Soluble Corrole Layer Deposited onto Au(111).	Water	76-81	sulfotransferase family 1A member 3	Homo sapiens	53-56
14687582-9	2004	The inhibition could also be related with the secretagogue effect of TNF-alpha on the gut since the intracellular tissue water was affected and the absence of chloride ion in the incubation medium partly removed the cytokine inhibition on sugar intestinal transport in treated rabbits.	Water	121-126	tumor necrosis factor	Oryctolagus cuniculus	69-78
30351033-10	2018	Furthermore, to our knowledge, it is the first study to compare biofilm in a tap water-fed, bench-scale simulated distribution system to biofilm on water mains from the full-scale system supplying the tap water.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
30457986-5	2018	We found that impaired LK signaling in Lk and Lk receptor (Lkr) mutants affects diverse but coordinated processes, including regulation of stress, water homeostasis, feeding, locomotor activity, and metabolic rate.	Water	147-152	Leucokinin	Drosophila melanogaster	23-25
30353860-2	2018	This pathway subserves the flow of CSF into the brain along arterial perivascular spaces and subsequently into the brain interstitium, facilitated by aquaporin 4 (AQP4) water channels.	Water	169-174	aquaporin 4	Homo sapiens	150-161
30353860-2	2018	This pathway subserves the flow of CSF into the brain along arterial perivascular spaces and subsequently into the brain interstitium, facilitated by aquaporin 4 (AQP4) water channels.	Water	169-174	aquaporin 4	Homo sapiens	163-167
30457986-7	2018	We find that the calcium activity in abdominal ganglia LK neurons (ABLKs), but not in the two sets of brain neurons, increases specifically following water consumption, suggesting that ABLKs regulate water homeostasis and its associated physiology.	Water	150-155	Leucokinin	Drosophila melanogaster	55-57
14753273-1	2004	A liquid chromatography-mass spectrometry (LC/MS) method was developed for the separation and determination of linear alkylbenzenesulfonates (C10-C14 LAS) in environmental water samples using a hydrophilic polymer column (Shodex Mspak GF-310 4D).	Water	172-177	lipoic acid synthetase	Homo sapiens	150-153
30457986-7	2018	We find that the calcium activity in abdominal ganglia LK neurons (ABLKs), but not in the two sets of brain neurons, increases specifically following water consumption, suggesting that ABLKs regulate water homeostasis and its associated physiology.	Water	200-205	Leucokinin	Drosophila melanogaster	55-57
30351099-2	2018	Hydrogen atoms, split from water, add to the phenol ring at the ortho position, generating syn and anti rotamers with respect to the hydroxyl group.	Water	27-32	synemin	Homo sapiens	91-94
30056322-11	2018	Compared to ultrapure water, equal or higher removal efficiency was observed for HAAs spiked to tap water.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	96-99
30056322-11	2018	Compared to ultrapure water, equal or higher removal efficiency was observed for HAAs spiked to tap water.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
14753273-3	2004	The LAS components were separated on the column with a mobile phase of 29% (w/v) acetonitrile-water containing 0.8 mM di-n-butylammonium acetate and 0.2 M acetic acid, and were detected by mass spectrometry with electrospray ionization.	Water	94-99	lipoic acid synthetase	Homo sapiens	4-7
14753273-5	2004	The concentrations of the C10-C14 LAS in the environmental water samples ranged between 5-317 microg L(-1) for a river water sample and 0.4-6.4 microg L(-1) for a seawater sample.	Water	59-64	lipoic acid synthetase	Homo sapiens	34-37
30103048-1	2018	Occurrence of residual endotoxin activity (ET) in dialysis water and also tap water as its source is a matter of great concern to medical professionals conducting dialysis therapy at healthcare facilities (HCFs).	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
14753273-5	2004	The concentrations of the C10-C14 LAS in the environmental water samples ranged between 5-317 microg L(-1) for a river water sample and 0.4-6.4 microg L(-1) for a seawater sample.	Water	119-124	lipoic acid synthetase	Homo sapiens	34-37
14728698-6	2004	Thirdly, and equally important, is natural moisturizing factor (NMF), a complex mixture of low-molecular-weight, water-soluble compounds first formed within the corneocytes by degradation of the histidine-rich protein known as filaggrin.	Water	113-118	filaggrin	Homo sapiens	227-236
30199802-2	2018	Adsorbable organic halogen (AOX) is a parameter conventionally used to indicate the sum of organic halogenated disinfection byproducts (DBPs), which are formed from the reactions of disinfectants with dissolved organic matter, bromide and iodide in water.	Water	249-254	acyl-CoA oxidase 1	Homo sapiens	28-31
30199807-2	2018	Adsorbable organic halogen (AOX) is a bulk organic parameter conventionally used to indicate all adsorbable halogenated organic disinfection byproducts formed in disinfected water.	Water	174-179	acyl-CoA oxidase 1	Homo sapiens	28-31
30429524-0	2018	Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice.	Water	32-37	low density lipoprotein receptor	Mus musculus	78-90
30336006-5	2018	These redox-active materials for removing Hg2+ from water create an attractive system that combines efficiency, capacity, selectivity, and reusability.	Water	52-57	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	42-45
30384725-2	2018	A new promising method for spin-isomer separation is magnetic focusing, a method which was shown to be capable of producing a molecular beam of ortho-water.	Water	150-155	spindlin 1	Homo sapiens	27-31
15314257-4	2004	The cholesterol-induced accumulation of Abeta in rabbit brain is increased when distilled drinking water is supplemented with 0.12 ppm copper ion (as copper sulfate) compared to the cholesterol-induced accumulation of Abeta in rabbit brain of animals given unaltered distilled water.	Water	99-104	amyloid beta (A4) precursor protein	Mus musculus	40-45
14959887-11	2004	However, Ac-ETVK-NH2 in water with small amounts of NaN3 and hexafluoroisopropanol greatly increased the beta-sheet content of NAC after standing the solution for more than 1 week.	Water	24-29	synuclein alpha	Homo sapiens	127-130
30141896-4	2018	Here, we develop amphiphilic triblock copolymer-based dissolving MNs in situ that generate nanomicelles (NMCs) upon their dissolution after cutaneous application, which facilitate the efficient encapsulation of poorly water-soluble Toll-like receptor 7/8 agonist (R848) and the delivery of hydrophilic antigens.	Water	218-223	toll-like receptor 7	Mus musculus	232-252
30224050-0	2018	Water Distribution within Wild-Type NRas Protein and Q61 Mutants during Unrestrained QM/MM Dynamics.	Water	0-5	NRAS proto-oncogene, GTPase	Homo sapiens	36-40
30357171-2	2018	The reaction can proceed by abstraction of either the terminal hydrogen atom of OOH group producing CH3O, O2 and H2O, or one hydrogen atom of the CH3 group forming H2CO, HO2 and H2O.	Water	178-181	EBP cholestenol delta-isomerase	Homo sapiens	100-108
14646147-7	2004	The interface between the Fab and TF molecules contains 15 water molecules, and yields buried surface areas as wide as 2000 A2.	Water	59-64	FA complementation group B	Homo sapiens	26-29
30224050-3	2018	The NRas-GTP complex is analyzed using a hybrid quantum mechanics/molecular mechanics approach, treating for the first time to our knowledge transient water molecules at the ab initio level and leading to results that account for the electrostatic coupling between the protein complex and the solvent.	Water	151-156	NRAS proto-oncogene, GTPase	Homo sapiens	4-8
30224050-6	2018	The structural changes observed in NRas Gln 61 mutants result in the drastic delocalization of water molecules that we discuss.	Water	95-100	NRAS proto-oncogene, GTPase	Homo sapiens	35-39
14646147-7	2004	The interface between the Fab and TF molecules contains 15 water molecules, and yields buried surface areas as wide as 2000 A2.	Water	59-64	coagulation factor III, tissue factor	Homo sapiens	34-36
14675048-14	2004	There was also a decrease in medullar expression of the AQP2 collecting duct water channel.	Water	77-82	aquaporin 2	Rattus norvegicus	56-60
30170158-4	2018	The aim of the present study is to determine whether apelin-13 ameliorates chronic water-immersion restraint stress (CWIRS)-induced depression-like phenotypes and its neural mechanism in rats.	Water	83-88	apelin	Rattus norvegicus	53-59
29803040-7	2018	Chloraminated water with a Cl2/N molar ratio of 0.6 or NOM concentration &lt;2 mg-C L-1 inhibited odor intensity.	Water	14-19	endogenous retrovirus group W member 5	Homo sapiens	27-51
15561403-5	2004	A quantitative analysis of the need for aquaporin-based water movements to accompany the known rates of CSF production is also presented.	Water	56-61	colony stimulating factor 2	Homo sapiens	104-107
30207682-11	2018	The sensor was also found very efficient for MV determination in real water systems (well, spring, and tap water) despite the decrease of sensitivity due to the presence of interfering species.	Water	107-112	nuclear RNA export factor 1	Homo sapiens	103-106
15329882-2	2004	Because of the proximity of the proton affinities of HCN and H2O molecules, the presence of water vapour can significantly distort HCN analysis in the presence of water vapour and a more sophisticated analytical procedure has to be developed.	Water	61-64	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	131-134
30281598-9	2018	In the case control study, typhoid was found to be associated with ever using tap water from the municipal supply (OR = 4.29, 95% CI 2.20-8.38).	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
15329882-2	2004	Because of the proximity of the proton affinities of HCN and H2O molecules, the presence of water vapour can significantly distort HCN analysis in the presence of water vapour and a more sophisticated analytical procedure has to be developed.	Water	92-97	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	53-56
15329882-2	2004	Because of the proximity of the proton affinities of HCN and H2O molecules, the presence of water vapour can significantly distort HCN analysis in the presence of water vapour and a more sophisticated analytical procedure has to be developed.	Water	92-97	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	131-134
30305990-7	2018	Moreover, the immobilized tyrosinase was able to degrade phenol dissolved in real water samples up to 78% after incubation for 60 min.	Water	82-87	tyrosinase	Homo sapiens	26-36
15329882-2	2004	Because of the proximity of the proton affinities of HCN and H2O molecules, the presence of water vapour can significantly distort HCN analysis in the presence of water vapour and a more sophisticated analytical procedure has to be developed.	Water	163-168	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	53-56
30542609-1	2018	Recently, interest in the potential applications of tin disulphide nanoflowers (SnS2 NFs) in the treatment of waste water and their antibacterial properties has increased.	Water	116-121	sodium channel, voltage-gated, type XI, alpha	Mus musculus	80-84
15329882-2	2004	Because of the proximity of the proton affinities of HCN and H2O molecules, the presence of water vapour can significantly distort HCN analysis in the presence of water vapour and a more sophisticated analytical procedure has to be developed.	Water	163-168	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	131-134
15329882-3	2004	Thus, the reactions of H3O+(H2O)0,1,2,3 ions with HCN molecules have been studied in the presence of varying concentrations of water vapour, reactions on which SIFT-MS analysis of HCN relies.	Water	28-31	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	50-53
15329882-3	2004	Thus, the reactions of H3O+(H2O)0,1,2,3 ions with HCN molecules have been studied in the presence of varying concentrations of water vapour, reactions on which SIFT-MS analysis of HCN relies.	Water	28-31	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	180-183
14670455-6	2004	The changes in the vibrational characteristics (vibrational frequencies and infrared intensities) arising from the hydrogen bonding between HONO2 and H2O have been estimated by using the ab initio calculations at SCF and MP2 levels and B3LYP/6-31G(d,p) calculations.	Water	150-153	tryptase pseudogene 1	Homo sapiens	221-224
14673097-11	2003	We consider that these conformational features and water contacts are involved in stabilizing the hydrogen bond interactions between helix-3 residues of Ets-1 and DNA during the transcription process.	Water	51-56	ETS proto-oncogene 1, transcription factor	Homo sapiens	153-158
30260527-5	2018	In addition, these SNF/HAP:CNF nanocomposites can be programmed into "grab-and-release" actuators due to the gradient structure of the nanocomposites as well as the high water sensitivity of each of the components, and thusshow potential applications in the design of novel third-generation biomaterials for potential clinical applications.	Water	170-175	NPHS1 adhesion molecule, nephrin	Homo sapiens	27-30
29959868-10	2018	In summary, position 414 in the active site was identified to modulate the electron shuttling from the FAD of the GOx to small water-soluble mediators dependent on the polarity and size of residue 414 and on the polarity and size of the mediator.	Water	127-132	hydroxyacid oxidase 1	Homo sapiens	114-117
14661029-6	2003	Direct and water-mediated intermolecular contacts are restricted to the backbone phosphates and sugar 2"-OH groups, consistent with sequence-independent p19-siRNA recognition.	Water	11-16	interleukin 23 subunit alpha	Homo sapiens	153-156
30007618-5	2018	Addition of the CNF filler into the TPS matrix decreased the apparent density and water absorption.	Water	82-87	NPHS1 adhesion molecule, nephrin	Homo sapiens	16-19
14500765-0	2003	Downregulation of renal AQP2 water channel and NKCC2 in mice lacking the apical Na+-H+ exchanger NHE3.	Water	29-34	aquaporin 2	Mus musculus	24-28
30007663-1	2018	This paper addresses the issue of high water retention by cellulose nanofibers (CNFs) that lead to exorbitant time consumption in the dewatering of CNF suspensions.	Water	39-44	NPHS1 adhesion molecule, nephrin	Homo sapiens	80-83
14500765-5	2003	Northern hybridization and immunoblotting studies indicated that the mRNA expression and protein abundance of the collecting duct (CD) water channel AQP2 decreased by 52 % (P &lt; 0.0003) and 73 % (P &lt; 0.003) in the cortex, and by 53 % and 54 % (P &lt; 0.002) in the inner medulla (IM) of Nhe3-/- vs. Nhe3+/+ mice.	Water	135-140	aquaporin 2	Mus musculus	149-153
29940529-9	2018	The BLC photocatalyst is a promising multi-functional catalyst utilizing LFP (rarely used as photocatalyst) for treatment of pharmaceutical waste water and other environmental applications.	Water	146-151	C-X-C motif chemokine ligand 13	Homo sapiens	4-7
14712517-8	2003	NO can also slow the degradation of CCNU in water solution.	Water	44-49	cyclin O	Homo sapiens	36-40
30223917-4	2018	Here we present a reaction for identification of carbamate-type drugs, based on the precipitation of barium carbonate upon treating the analytes with barium hydroxide solution at 80  C. This method works well for carbamate drugs with noteworthy water solubility like carbachol, neostigmine bromide, and pyridostigmine bromide, and could be considered as a method for second identification of these drugs in pharmacopoeias and in Deutscher Arzneimittel-Codex/Neues Rezeptur-Formularium (DAC-NRF).	Water	245-250	NFKB repressing factor	Homo sapiens	490-493
12881219-12	2003	The addition of 17-octadecynoic acid, a cytochrome P-450 monooxygenase inhibitor, to those inhibitors significantly attenuated the ACh-induced decreases in fluorescence intensity, whereas catalase, an enzyme that dismutates H2O2 to form water and oxygen, did not.	Water	237-242	Cytochrome P450 1A1	Canis lupus familiaris	40-56
30345835-9	2018	In conclusion, a carbonated water mouthwash can significantly reduce oropharyngeal NO compared to a tap water mouthwash at expiratory flows of 30-300 mL/s without affecting the CANO and DawNO.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
12855592-8	2003	This localization implicates all four isotypes in movement of water during uterine imbibition and, based on their localization to the luminal epithelial cells, AQP-2 and -3 in facilitating water movement into the lumen of the uterus.	Water	189-194	aquaporin 2	Mus musculus	160-172
29890477-8	2018	In a subset of study participants who did not use home water filters, consumption of at least some amount of non-boiled tap water reported in a monthly recall survey was associated with 11.1 (1.2; 100.0) and 0.6 (0.1; 2.5) aORs of immunoconversion to Cryptosporidium before and after the new water treatment plant construction, respectively.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	120-123
29890477-9	2018	Among individuals who used home water filters, associations between non-boiled tap water consumption and Cryptosporidium immunoconversion were not significant before and after new plant construction with aORs of 0.8 (0.2; 3.3) and 0.3 (0.1; 1.6), respectively.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
14613785-6	2003	Water deprivation significantly decreased the relative levels of CNP and NPR-B mRNA expression in both the 7- and 14-day water-deprived hopping mice, when compared to control hopping mice.	Water	0-5	natriuretic peptide receptor 2	Mus musculus	73-78
30728998-10	2018	Conclusion: Based on the results of the tap-water quality application of POU-WT systems are not recommended in Tehran and Rasht, and regarding the outputs of these systems, side effects of softened water, lack of Fluoride and a remarkable increase of the number of bacteria should be considered.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
30319697-8	2018	Tap water distribution was poor in this slum area.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
14613785-6	2003	Water deprivation significantly decreased the relative levels of CNP and NPR-B mRNA expression in both the 7- and 14-day water-deprived hopping mice, when compared to control hopping mice.	Water	121-126	natriuretic peptide receptor 2	Mus musculus	73-78
14613785-8	2003	This study shows that alterations in the renal CNP/NPR-B system may be an important physiological adjustment when water is scarce.	Water	114-119	natriuretic peptide receptor 2	Mus musculus	51-56
14512384-6	2003	These results suggest some correlation between the activities of beta-mannosidase and endo-beta-mannanase, particularly in the micropylar endosperm, in populations of tomato seeds imbibed in water, abscisic acid and gibberellin.	Water	191-196	beta-mannosidase	Solanum lycopersicum	65-81
29945113-4	2018	The fabricated label-free fluorescence aptasensor is not only conveniently but also effectively applicable used for analysis of Hg2+ ion in blood serum and tap water samples and the recovery range is of 96.0%-105.7%.	Water	160-165	nuclear RNA export factor 1	Homo sapiens	156-159
14572217-10	2003	When examined separately, scrubbing with a vegetable brush in tap water, washing with soap, and dipping in chlorine were found to reduce the bacterial load by 70, 80, and 90%, respectively.	Water	66-71	RepA leader peptide Tap	Salmonella enterica	62-65
30515390-16	2018	Consumption of coconut water significantly increased urinary citrate (29%, p=0.02), urinary potassium (130%, p=0.01), and urinary chloride (37%, p=0.03), without affecting urine pH (p=0.16) or volume beyond that of tap water (p=1.00).	Water	23-28	nuclear RNA export factor 1	Homo sapiens	215-218
12918043-4	2003	Modified PUs showed the stable entrapment of the PRx-SO(3)"s with little extraction into water and enhanced mechanical properties after exposure to water compared to the PU control.	Water	89-94	periaxin	Homo sapiens	49-52
30185826-5	2018	We conclude based on the consistent part of the datasets that the core/dimerization domain of Bax (Bak) is water exposed with only helices 4 and 5 in membrane contact, whereas the piercing/latch domain is in peripheral membrane contact, with helix 9 being transmembrane.	Water	107-112	BCL2 antagonist/killer 1	Homo sapiens	99-102
12918043-4	2003	Modified PUs showed the stable entrapment of the PRx-SO(3)"s with little extraction into water and enhanced mechanical properties after exposure to water compared to the PU control.	Water	148-153	periaxin	Homo sapiens	49-52
30056622-1	2018	OBJECTIVES: Diffusion-weighted MRI provides information regarding body water movement following death, which may be an imaging marker of post-mortem interval (time since death; PMI) or maceration (degree of tissue degradation during intra-uterine retention) in perinatal deaths.	Water	71-76	transmembrane protein 11	Homo sapiens	177-180
12900507-0	2003	Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities.	Water	134-139	synuclein alpha	Homo sapiens	35-50
30378126-3	2018	The water-permeable channel aquaporin-4 (AQP4) is expressed at high concentrations at these endfeet, held in place by the dystrophin glycoprotein complex (DGC), a collection of proteins that act as a bridge linking AQP4 to the laminin-containing basal lamina found in between the blood vessels and the astrocytic endfeet.	Water	4-9	aquaporin 4	Mus musculus	28-39
30378126-3	2018	The water-permeable channel aquaporin-4 (AQP4) is expressed at high concentrations at these endfeet, held in place by the dystrophin glycoprotein complex (DGC), a collection of proteins that act as a bridge linking AQP4 to the laminin-containing basal lamina found in between the blood vessels and the astrocytic endfeet.	Water	4-9	aquaporin 4	Mus musculus	41-45
30378126-3	2018	The water-permeable channel aquaporin-4 (AQP4) is expressed at high concentrations at these endfeet, held in place by the dystrophin glycoprotein complex (DGC), a collection of proteins that act as a bridge linking AQP4 to the laminin-containing basal lamina found in between the blood vessels and the astrocytic endfeet.	Water	4-9	aquaporin 4	Mus musculus	215-219
30378126-4	2018	Although AQP4, supported by the DGC, has well-established roles in facilitating certain neurological processes, and in mediating the removal of excess water from the brain in certain disease states, relatively few studies have looked at the importance of these components in the regulation of the extension of the processes that are so characteristic of astrocytes.	Water	151-156	aquaporin 4	Mus musculus	9-13
12948596-8	2003	These results indicate that water homeostasis in the inner ear is regulated via the vasopressin-AQP2 system, and that the vasopressin type-2 antagonist OPC-31260 is a promising drug in the treatment of Meniere"s disease.	Water	28-33	aquaporin 2	Rattus norvegicus	96-100
30297500-4	2018	Two intervention groups of DCC families performed educational and hand hygiene measures, 1 with soap and water (SWG; n = 274), another with hand sanitizer (HSG; n = 339), and the control group (CG; n = 298) followed usual hand-washing procedures.	Water	105-110	DCC netrin 1 receptor	Homo sapiens	27-30
12874453-7	2003	Administration of tetracycline in the drinking water was associated with podocyte expression of beta-galactosidase, in a fashion that was time dependent (maximal at 1 wk) and dose-dependent (maximal at 2 mg/ml).	Water	47-52	galactosidase, beta 1	Mus musculus	96-114
29903413-6	2018	Simulations revealed that an organized water is displaced by zanamivir in binding to NEU2 and NEU3 and confirmed the critical importance of engaging the binding pocket of the C7-C9 glycerol sidechain.	Water	39-44	neuraminidase 2	Homo sapiens	85-89
29903413-6	2018	Simulations revealed that an organized water is displaced by zanamivir in binding to NEU2 and NEU3 and confirmed the critical importance of engaging the binding pocket of the C7-C9 glycerol sidechain.	Water	39-44	neuraminidase 3	Homo sapiens	94-98
12827675-0	2003	An ab initio study of microsolvation of LiF in water: structures and properties of LiF-Wn, n = 1-9 complexes.	Water	47-52	LIF interleukin 6 family cytokine	Homo sapiens	40-43
28778418-12	2018	Moreover, IL-17A Ab significantly reduced brain water content and improved neurological function of ICH mice.	Water	48-53	interleukin 17A	Mus musculus	10-16
12827675-0	2003	An ab initio study of microsolvation of LiF in water: structures and properties of LiF-Wn, n = 1-9 complexes.	Water	47-52	LIF interleukin 6 family cytokine	Homo sapiens	83-86
12827675-11	2003	An appreciable amount of electronic charge is transferred from LiF to the water molecules involved in the different complexes.	Water	74-79	LIF interleukin 6 family cytokine	Homo sapiens	63-66
12929843-8	2003	In general, high APCs were found on the wall of the recirculating water tank both POST and PRE.	Water	66-71	solute carrier family 35 member G1	Homo sapiens	82-86
29852990-5	2018	Furthermore, the biosensor can be recovered very easily by incubating it in water to dissociate the AuNPs modified with Apt 1 and pAPG.	Water	76-81	lysophospholipase 1	Homo sapiens	120-125
12846749-6	2003	In response to water deprivation, AQP2 and AQP3 expression increased significantly in the cortex and medulla of 2-month-old rats but remained unchanged in the medulla or slightly increase in the cortex of 7-month-old animals.	Water	15-20	aquaporin 2	Rattus norvegicus	34-38
29894954-0	2018	A highly selective fluorescent probe for the detection of hypochlorous acid in tap water and living cells.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
29894954-5	2018	Moreover, the probe was used for the detection of HClO in tap water through the home-made test paper.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
12846749-6	2003	In response to water deprivation, AQP2 and AQP3 expression increased significantly in the cortex and medulla of 2-month-old rats but remained unchanged in the medulla or slightly increase in the cortex of 7-month-old animals.	Water	15-20	aquaporin 3 (Gill blood group)	Rattus norvegicus	43-47
30188134-0	2018	Effects of Ca2+ Ion Condensation on the Molecular Structure of Polystyrene Sulfonate at Air-Water Interfaces.	Water	92-97	carbonic anhydrase 2	Homo sapiens	11-14
12902192-5	2003	However, JNK activation in response to Cr(VI) and exogenous H(2)O(2) (1 mM) shared requirements for intracellular thiol oxidation, activation of Src family kinases, and p130(cas) (Cas).	Water	60-65	BCAR1 scaffold protein, Cas family member	Homo sapiens	169-178
29920408-7	2018	Consequently, a 50% lower methadone degradation rate was observed when deionized (DI) water was replaced with tap water.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	110-113
30404486-1	2018	The cascade of blind deconvolution and array invariant has been successful to localize and track a surface ship radiating random waveforms, using a 56-m long vertical array in 100-m deep shallow water.	Water	195-200	inositol polyphosphate-5-phosphatase D	Homo sapiens	107-111
12902192-5	2003	However, JNK activation in response to Cr(VI) and exogenous H(2)O(2) (1 mM) shared requirements for intracellular thiol oxidation, activation of Src family kinases, and p130(cas) (Cas).	Water	60-65	BCAR1 scaffold protein, Cas family member	Homo sapiens	180-183
12815427-5	2003	We then use a hydraulic model of the water exchange between the Red Sea and the world ocean to derive the sill depth-and hence global sea level-over the past 470,000 years (470 kyr).	Water	37-42	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	68-71
30404518-3	2018	The subsequent array invariant confirms that a surface ship and a towed source at 50-m depth can be simultaneously localized using a 56-m long vertical array in 100-m deep shallow water.	Water	180-185	inositol polyphosphate-5-phosphatase D	Homo sapiens	55-59
30285963-0	2018	Drinking water in West Virginia (USA): tap water or bottled water - what is the right choice for college students?	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
30285963-6	2018	Results indicated that a third of the student population primarily used bottled water for drinking purposes at home, while 39% used a filter at home and 26% drank water directly from the tap.	Water	163-168	nuclear RNA export factor 1	Homo sapiens	187-190
12854727-1	2003	The strength and the character of the binding of 14 organic solvents to the corn protein zein in distilled water and in various salt solutions were determined by preparing zein-coated carbon stationary phase and by measuring the retention characteristics of solvents on a high-performance liquid chromatographic column filled with this stationary phase.	Water	107-112	zein	Zea mays	89-93
12631554-9	2003	Intrarenal expression of the FP receptor in the DCT and CCD suggests an important role for the FP receptor regulating water and solute transport in these segments of the nephron.	Water	118-123	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	Mus musculus	29-31
30122483-4	2018	Recent studies revealed that the water channel protein aquaporin 4 (AQP4) mediates the glymphatic system to clear interstitial solutes, including beta-amyloid, from the brain.	Water	33-38	aquaporin 4	Homo sapiens	55-66
30122483-4	2018	Recent studies revealed that the water channel protein aquaporin 4 (AQP4) mediates the glymphatic system to clear interstitial solutes, including beta-amyloid, from the brain.	Water	33-38	aquaporin 4	Homo sapiens	68-72
12631554-9	2003	Intrarenal expression of the FP receptor in the DCT and CCD suggests an important role for the FP receptor regulating water and solute transport in these segments of the nephron.	Water	118-123	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	Mus musculus	95-97
29723839-0	2018	SAR interferometry monitoring of subsidence in a detritic basin related to water depletion in the underlying confined carbonate aquifer (Torremolinos, southern Spain).	Water	75-80	sarcosine dehydrogenase	Homo sapiens	0-3
12802890-2	2003	Two weeks of 10 min/day in 37 degrees C water increased dopamine-beta-hydroxylase staining density in the locus coeruleus but did not enhance novel object investigation.	Water	40-45	dopamine beta-hydroxylase	Rattus norvegicus	56-81
29913610-7	2018	The isolated effect of climate change results in an expected increase in irrigation water requirements of 19 MCM by 2025 and 64 MCM by 2050.	Water	84-89	methylmalonyl-CoA mutase	Homo sapiens	109-112
29978422-0	2018	DNA extraction from amoebal isolates and genotype determination of Acanthamoeba from tap water in Latvia.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
29978422-3	2018	This is the first study in Latvia describing Acanthamoeba detection by molecular techniques and genotyping using tap water from different sources.	Water	117-122	nuclear RNA export factor 1	Homo sapiens	113-116
29978422-5	2018	The results indicate that tap water in Latvia may be a source of Acanthamoeba that is potentially pathogenic to humans.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
30188129-5	2018	Here, we also report the structural difference between D3O+ and H3O+ in bulk heavy/light water.	Water	89-94	H3 clustered histone 15	Homo sapiens	64-67
12771194-7	2003	Accessibility tests of the introduced thiol groups to extracellular MTS reagents indicate that water-filled crevices penetrate deep into the HERG protein core, reaching the cytoplasmic halves of S1 and S2.	Water	95-100	potassium voltage-gated channel subfamily H member 2	Homo sapiens	141-145
30188715-2	2018	Here we show that water dynamics and interactions can be controlled by the protonation state of ligand using continuous constant pH molecular dynamics simulations of two closely related model systems, beta-secretase 1 and 2 (BACE1 and BACE2), in complex with a small-molecule inhibitor.	Water	18-23	beta-secretase 2	Homo sapiens	235-240
30217234-7	2018	RESULTS: Ion channels exhibited cut-off effects associated with hydrocarbon molar water solubility in the following order of decreasing solubility: Nav1.2   Nav1.4   TRESK   TREK-1 &gt; GABAA &gt;&gt; glycine.	Water	82-87	sodium voltage-gated channel alpha subunit 2	Homo sapiens	148-154
30156112-0	2018	Effect of Spin Polarization on the Exclusion Zone of Water.	Water	53-58	spindlin 1	Homo sapiens	10-14
15012730-10	2003	For specific conditions where renal water retention is stimulated via AVP, urinary AQP2 measurements provide a reproducible measurement of the renal actions of AVP.	Water	36-41	aquaporin 2	Homo sapiens	83-87
30156112-8	2018	Therefore, a chiral symmetry-breaking phenomenon was observed, which shows that the formation of the EZ water may evolve certain quantum effects related to the chiral induced spin selectivity effect.	Water	104-109	spindlin 1	Homo sapiens	175-179
29873838-2	2018	Attributed to the flexibility of the framework, Mn-sdc-1 can transform into a new phase (Mn-sdc-2) with completely different structural geometry; this is induced by trace levels of H2 O at room temperature.	Water	181-185	syndecan 2	Homo sapiens	92-97
29908205-1	2018	Remote Infrared Matrix Assisted Laser Desorption Ionization (Remote IR MALDI) system (SpiderMass) with endogenous water as matrix allows to perform real-time DMPK in vivo.	Water	114-119	DM1 protein kinase	Homo sapiens	158-162
30196635-0	2018	[The transformation of microcystin-LR during tap water treatment process and analysis of its degradation products].	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
12621104-1	2003	The osmotic water permeability (Pf) of the rabbit proximal tubule brush border membrane vesicles (BBMV) increases during maturation and is mediated by an increase in aquaporin-1 (AQP1) protein expression.	Water	12-17	aquaporin-1	Oryctolagus cuniculus	166-177
30254507-8	2018	The present study provides evidence that DNA methylation of Tbx21 and Rorc may be associated with the development of EAU.	Water	117-120	T-box 21	Mus musculus	60-65
29873838-3	2018	Reversibly, the transformation from Mn-sdc-2 to Mn-sdc-1 can be triggered by DMF upon heating beyond 100  C. These results inspired a study of the influences of temperature and H2 O volume in the solid-state transformation of two MOF phases and, for the first time, a phase diagram of MOFs has been depicted.	Water	177-181	syndecan 2	Homo sapiens	39-44
29873838-4	2018	This phase diagram reflects the gradual H2 O-/temperature-dependent changes between Mn-sdc-1 and Mn-sdc-2, which is very meaningful in achieving the controllable synthesis of these two MOFs and lead to targeting the desired water-stable structure.	Water	40-44	syndecan 2	Homo sapiens	100-105
29873838-4	2018	This phase diagram reflects the gradual H2 O-/temperature-dependent changes between Mn-sdc-1 and Mn-sdc-2, which is very meaningful in achieving the controllable synthesis of these two MOFs and lead to targeting the desired water-stable structure.	Water	224-229	syndecan 2	Homo sapiens	100-105
29873838-5	2018	As a result, the obtained water-stable Mn-sdc-2 can be developed as an excellent Pb2+ sensor in aqueous solution through the luminescence quenching effect with a limit of detection of 31.4 nm.	Water	26-31	syndecan 2	Homo sapiens	42-47
29979191-8	2018	CD362 human mesenchymal stromal cells enhanced resolution after ventilator-induced lung injury in rodents, restoring arterial oxygenation (mean +- SD: 113 +- 11 vs. 89 +- 11 mmHg, P &lt; 0.05) and lung static compliance (mean +- SD: 0.74 +- 0.07 vs. 0.45 +- 0.07 ml   cm H2O, P &lt; 0.05), resolving lung inflammation, and restoring histologic structure compared with vehicle.	Water	271-274	syndecan 2	Homo sapiens	0-5
12621104-1	2003	The osmotic water permeability (Pf) of the rabbit proximal tubule brush border membrane vesicles (BBMV) increases during maturation and is mediated by an increase in aquaporin-1 (AQP1) protein expression.	Water	12-17	aquaporin-1	Oryctolagus cuniculus	179-183
12632405-5	2003	Ninety percent of the initial activity of immobilized VHb-DAO could be maintained at up to 50 cycles of the enzymatic reaction without exogenous addition of H(2)O(2) and flavin adenine dinucleotide (FAD).	Water	157-162	D-amino acid oxidase	Homo sapiens	58-61
30045118-0	2018	Real-Time Monitoring of Gross Beta Radioactivity in Tap Water and Committed Effective Dose.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
12679863-2	2003	By using this technique, conformations of four proteins, viz., beta-casein, bovine serum albumin (BSA), lysozyme, and fibrinogen in the adsorbed state at the air-water interface have been studied.	Water	162-167	casein beta	Homo sapiens	63-74
30045118-3	2018	Finally, the annual committed effective doses to children and adults who drank the tap water for a long time were estimated.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
30045118-4	2018	The results showed that the gross beta radioactivity in tap water was 0.09 +- 0.03 Bq L using the scintillating fiber array system and 0.076 +- 0.009 Bq L using the evaporation concentration method.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
12679863-3	2003	beta-Casein, which is predominantly in a disordered state in solution, assumes a beta-sheet conformation at the air-water interface.	Water	116-121	casein beta	Homo sapiens	0-11
30409949-7	2018	Regular tap water was used for immersion in the control group.	Water	12-17	nuclear RNA export factor 1	Homo sapiens	8-11
12606488-5	2003	The results show that AQP-9 alone caused an increase in oocyte water permeability, which could be further potentiated by CFTR.	Water	63-68	CF transmembrane conductance regulator	Rattus norvegicus	121-125
29745802-5	2018	Tsk was manipulated by having subjects wear a water-perfused suit that covered most of the body and maintained Tsk that was significantly different between trials and averaged 32.4 +- 0.2, 35.5 +- 0.1, 37.5 +- 0.1, and 39.5 +- 0.1 C, respectively.	Water	46-51	tsukushi, small leucine rich proteoglycan	Homo sapiens	0-3
12606488-7	2003	The regulation of water permeability by CFTR was also demonstrated in intact rat epididymis luminally perfused with a hypo-osmotic solution.	Water	18-23	CF transmembrane conductance regulator	Rattus norvegicus	40-44
12606488-10	2003	These results are consistent with a role for CFTR in controlling water permeability in the epididymis in vivo.	Water	65-70	CF transmembrane conductance regulator	Rattus norvegicus	45-49
12734902-4	2003	For ARS, 1% ARS dissolved in distilled water was adjusted to pH 6.4 by adding 0.1% ammonia solution drop by drop while stirring.	Water	39-44	secreted LY6/PLAUR domain containing 1	Homo sapiens	12-15
30069980-9	2018	Water avoidance stress-derived mucosal supernatants markedly enhanced the c-fos expression and enteric synaptic plasticity in LMMP tissues, which could be eliminated by mast cell inhibition or NGF neutralization, but not tryptase or histamine blocking.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-79
12700414-3	2003	In this study we show by electrophoretic mobility-shift assay (EMSA) that enriched splenic NK cells from EtOH-consuming C57BL/6 mice exhibit reduced NF-kappaB and AP-1 binding activity in response to IL-2 stimulation as compared to the water-drinking mice.	Water	236-241	interleukin 2	Mus musculus	200-204
30221833-6	2018	In addition, the change in PA blood flow in response to immersion in carbonated water correlated with those of skin blood flow (P = 0.005) but not oxyhemoglobin concentration (P = 0.765) and tissue oxygenation index (P = 0.136) while no relations was found for tap water immersion.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	261-264
29710648-3	2018	The predominant compounds in tap water were perfluorohexane sulfonate (PFHxS), perfluoropentanoic acid (PFPeA), perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA), tris(2-chloroethyl) phosphate (TCEP), tris(chloroisopropyl) phosphate (TCIPP), and tris(2-butoxyethyl) phosphate (TBOEP).	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
12659950-1	2003	The interactions of chicken liver basic fatty acid-binding protein (Lb-FABP) with large unilamellar vesicles (LUVs) of palmitoyloleoyl phosphatidylcholine (POPC) and palmitoyloleoyl phosphatidylglycerol (POPG) were studied by binding assays, Fourier transform infrared (FT-IR) spectroscopy, monolayers at air-water interface, and low-angle X-ray diffraction.	Water	309-314	liver basic fatty acid binding protein	Gallus gallus	68-75
29710648-4	2018	Tap water originating from the Nakdong River within an industrial complex showed a notably higher PFHxS proportion to total PFASs.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
30152209-5	2018	In the livestock and poultry breeding environment, ARGs and antibiotic resistant bacteria could be transmitted to humans through the food chain, water or air, posing a great threat to public health.	Water	145-150	serpin family A member 2 (gene/pseudogene)	Homo sapiens	51-55
12684399-0	2003	A phase I trial of ZD9331, a water-soluble, nonpolyglutamatable, thymidylate synthase inhibitor.	Water	29-34	thymidylate synthetase	Homo sapiens	65-85
12690509-2	2003	In this study, we have retrospectively screened specific founder mutations in KCNQ1 (KVLQT1) and KCNH2 (HERG) genes in 165 consecutive bodies found in water in Finland.	Water	151-156	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	78-83
30043614-10	2018	The CNF-PPy/PB hybrid hydrogels also demonstrate attractive characteristics, including high water content (~94%), low density (~1.2 g cm-3), excellent biocompatibility, plasticity, pH sensitivity, and rapid self-healing ability without additional external stimuli.	Water	92-97	NPHS1 adhesion molecule, nephrin	Homo sapiens	4-7
30111737-7	2018	In this work, we present a 19-month time series measuring nitrate, chloride, and sulfate in local precipitation, reservoir and household tap waters in order to better understand the relationship of the hydrologic residence time on the tap water chemistry, as well as to evaluate the anion concentrations.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	137-140
30111737-8	2018	The highest chloride tap water concentration, 6.9 mM, occurred in early February 2011, while increases in nitrate occurred in both early summer and the middle of winter.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
30111737-10	2018	Similarly, the tap water had concentrations of chloride and sulfate higher than reservoir water, while nitrate was similar to reservoir water.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
30111737-11	2018	Tap water had higher fluoride and sulfate concentrations, suggesting that they are added during the treatment of the reservoir water prior to residential distribution.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
30111737-11	2018	Tap water had higher fluoride and sulfate concentrations, suggesting that they are added during the treatment of the reservoir water prior to residential distribution.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	0-3
12690509-2	2003	In this study, we have retrospectively screened specific founder mutations in KCNQ1 (KVLQT1) and KCNH2 (HERG) genes in 165 consecutive bodies found in water in Finland.	Water	151-156	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	85-91
12690509-2	2003	In this study, we have retrospectively screened specific founder mutations in KCNQ1 (KVLQT1) and KCNH2 (HERG) genes in 165 consecutive bodies found in water in Finland.	Water	151-156	potassium voltage-gated channel subfamily H member 2	Homo sapiens	97-102
12690509-2	2003	In this study, we have retrospectively screened specific founder mutations in KCNQ1 (KVLQT1) and KCNH2 (HERG) genes in 165 consecutive bodies found in water in Finland.	Water	151-156	potassium voltage-gated channel subfamily H member 2	Homo sapiens	104-108
30111761-2	2018	In Finland, tap water is the main source of drinking water, and thus the nitrite in tap water increases nitrite exposure.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
12631357-12	2003	CONCLUSION: The excretion of AQP-2 in urine is abnormal both in liver cirrhosis in which we find less suppression of u-AQP2 by an acute water load and in CHF in which we find a high baseline level and an exaggerated suppression of u-AQP2 by an acute water load.	Water	136-141	aquaporin 2	Homo sapiens	29-34
30111761-2	2018	In Finland, tap water is the main source of drinking water, and thus the nitrite in tap water increases nitrite exposure.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	84-87
30111761-2	2018	In Finland, tap water is the main source of drinking water, and thus the nitrite in tap water increases nitrite exposure.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	12-15
12631357-12	2003	CONCLUSION: The excretion of AQP-2 in urine is abnormal both in liver cirrhosis in which we find less suppression of u-AQP2 by an acute water load and in CHF in which we find a high baseline level and an exaggerated suppression of u-AQP2 by an acute water load.	Water	250-255	aquaporin 2	Homo sapiens	29-34
30111761-2	2018	In Finland, tap water is the main source of drinking water, and thus the nitrite in tap water increases nitrite exposure.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	84-87
30111761-2	2018	In Finland, tap water is the main source of drinking water, and thus the nitrite in tap water increases nitrite exposure.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	12-15
12646165-2	2003	In rats, dihydrotachysterol (DHT) induces AQP2 water channel downregulation despite unaltered AQP2 mRNA expression and thus we investigated the mechanism of AQP2 degradation.	Water	47-52	aquaporin 2	Rattus norvegicus	42-46
30111761-2	2018	In Finland, tap water is the main source of drinking water, and thus the nitrite in tap water increases nitrite exposure.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	84-87
30109505-6	2018	The temporal analysis revealed that the highest THM concentration occurred in April, both in tap water and in finished water, which was also shown by temporal cluster analysis.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
12617601-0	2003	Dynamics of competitive adsorption of alphas-casein and beta-casein at planar triolein-water interface: evidence for incompatibility of mixing in the interfacial film.	Water	87-92	casein beta	Homo sapiens	56-67
30150935-2	2018	Water-soluble hydroxypropyl (HPBCD) and randomly methylated (RAMEB) beta-cyclodextrins were designed to enhance anti-fibrotic efficiency of silymarin in CCl4-induced liver fibrosis in mice.	Water	0-5	chemokine (C-C motif) ligand 4	Mus musculus	153-157
12617601-7	2003	It is hypothesized that, because of thermodynamic incompatibility of mixing, the alpha(s)-casein and beta-casein mixed film at the oil-water interface may undergo two-dimensional phase separation.	Water	135-140	casein beta	Homo sapiens	101-112
12594459-1	2003	The observation of gullies on Mars indicates the presence of liquid water near the surface in recent times, which is difficult to reconcile with the current cold climate.	Water	68-73	methionyl-tRNA synthetase 1	Homo sapiens	30-34
30001104-7	2018	However, nanoscaled filaments containing beta-sheets dominated in the F-SAP aqueous solution, in which case water acted as a poor solvent of F-SAP.	Water	108-113	hyaluronan binding protein 2	Homo sapiens	70-75
30001104-8	2018	Furthermore, the results of molecular dynamics simulation implicated that water facilitated F-SAP aggregation, whereas HFIP inhibited it.	Water	74-79	hyaluronan binding protein 2	Homo sapiens	92-97
12650488-1	2003	BACKGROUND AND OBJECTIVE: We studied the pharmacokinetics and pharmacodynamics of GPI 15715 (Aquavan injection), a new water-soluble prodrug metabolized to propofol by hydrolysis.	Water	119-124	glucose-6-phosphate isomerase	Rattus norvegicus	82-85
30081519-6	2018	The presence of fungi in different types of water has been thoroughly investigated during the past 30 years only in Europe, and more than 400 different species were reported from ground-, surface-, and tap-water.	Water	206-211	nuclear RNA export factor 1	Homo sapiens	202-205
29740925-7	2018	Pharmacological doses of metformin in drinking water or intraperitoneal injection significantly elevated the global levels of H3K27me3 in the hepatic tissue of low-density lipoprotein receptor-deficient mice and in the tumor tissues of highly aggressive breast cancer xenograft-bearing mice.	Water	47-52	low density lipoprotein receptor	Mus musculus	160-192
30200555-9	2018	Compared to traditional method, we obtained the conversion formula between the concentration of residual-chlorine in tap water and the concentration of hypochlorite detected by the proposed colorimetric assay, which is Cresidual-chlorine = 0.24 CNaClO.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
30200555-10	2018	Finally, the real application of the colorimetric assay in tap water was successfully performed, and the accuracy of the colorimetric method can reach from -6.78% to +8.53%.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
12669220-22	2003	We showed that, assuming a two compartment model with fast proton exchange between the compartments, the absolute perfusion P (in [ml/g/min]) can be calculated as P = lambda/T1(blood) ([T1(global)/T1(selective)] - 1), where the blood tissue partition coefficient lambda represents the quotient of water content of capillary blood and perfused tissue, which is approximately 0.9 ml/g in myocardial tissue.	Water	297-302	CD1b molecule	Homo sapiens	177-182
29929094-2	2018	Debromination efficiency of 2,4,6-TBP was the highest in basic water (pH = 10.61).	Water	63-68	TATA-box binding protein	Homo sapiens	34-37
29929094-6	2018	In basic water both 2,4,6-TBP conversion and TOC removal decreased with an increase in CO32-, hence minimizing BrO3- formation.	Water	9-14	TATA-box binding protein	Homo sapiens	26-29
30189640-10	2018	A similar catalytic performance was also observed for three 4-nitrophenol spiked real water samples (e.g., surface water, tap water, and industrial dyeing wastewater).	Water	86-91	nuclear RNA export factor 1	Homo sapiens	122-125
33947175-0	2018	Oxygen and Hydrogen Isotopes in Human Hair and Tap Water: Modeling Relationships in a Modern Mexican Population.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
33947175-2	2018	The purpose of this study was twofold: to quantify the relationship between isotopes in Mexican hair and tap water, in order to understand the impact of water stress and differing socioeconomic status on accurate predictions of drinking water; and to determine whether currently existing semimechanistic models can accurately represent the relationship between hair and tap water.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	105-108
33947175-4	2018	Isotope values in tap water ranged from -11.4% to -4.3% and -79.1% to -22.5%, and in hair from +9.5% to +16.1% and -90.8% to -53.7%, for delta18O and delta2H, respectively.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
33947175-12	2018	They found that, although O and H isotopes in water and hair maintained similar geographic distributions, O and H isotopes in tap water explained only a small part of the variation observed in hair samples.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
29241298-7	2018	The SP2 and SP3 springs can derive from the mixing of the saline water (SP1 ) and fresh water (SP4 ).	Water	88-93	Sp4 transcription factor	Homo sapiens	95-98
12631731-2	2003	In this study, we found that Hic-5 accumulated in the nucleus in response to oxidants such as H(2)O(2).	Water	94-99	transforming growth factor beta 1 induced transcript 1	Homo sapiens	29-34
12523967-3	2003	As lipase-catalyzed esterification reactions in organic media are greatly influenced by the water content, the effect of the initial hydration level of the reaction medium components was pointed out for naringin palmitate synthesis.	Water	92-97	PAN0_003d1715	Moesziomyces antarcticus	3-9
29157042-2	2018	The present study investigated the effects of head-out water immersion (HOI) on serum BDNF concentrations.	Water	55-60	brain derived neurotrophic factor	Homo sapiens	86-90
29295626-3	2018	METHODS: Insufficient RFA was simulated in vitro by heating Huh7 cells in water bath at 47  C, named as Huh7-H.	Water	74-79	MIR7-3 host gene	Homo sapiens	60-64
29295626-3	2018	METHODS: Insufficient RFA was simulated in vitro by heating Huh7 cells in water bath at 47  C, named as Huh7-H.	Water	74-79	MIR7-3 host gene	Homo sapiens	104-108
30067239-3	2018	This study aimed to reveal actual water intakes from tap water and other types of drinks, and to explore the relationships between these intakes.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	53-56
12559597-2	2003	METHODS: The anti-inflammatory effects of the water extract of the S. melongena (SMWE) were investigated in PAR2-mediated mouse paw edema.	Water	46-51	pulmonary adenoma resistance 2	Mus musculus	108-112
30067239-5	2018	Tap water intake negatively correlated with bottled water and soft drink intakes, suggesting a mutually complementary relationship.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
30067239-5	2018	Tap water intake negatively correlated with bottled water and soft drink intakes, suggesting a mutually complementary relationship.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	0-3
30067239-6	2018	We propose an index, potential Tap Water Intake (pTWI), calculated by adding soft drinks and bottled water to tap water intake.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
30067239-6	2018	We propose an index, potential Tap Water Intake (pTWI), calculated by adding soft drinks and bottled water to tap water intake.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	110-113
30067239-6	2018	We propose an index, potential Tap Water Intake (pTWI), calculated by adding soft drinks and bottled water to tap water intake.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	31-34
30067239-6	2018	We propose an index, potential Tap Water Intake (pTWI), calculated by adding soft drinks and bottled water to tap water intake.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	31-34
30067239-6	2018	We propose an index, potential Tap Water Intake (pTWI), calculated by adding soft drinks and bottled water to tap water intake.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	110-113
29544141-8	2018	Tap water radon levels inside the spa present an average value of 50 +- 8 kBq m-3, which does not exceed the level stipulated by the Spanish Nuclear Safety Council (CSN) of 100 kBq m-3 for water used for human consumption.	Water	4-9	surfactant protein A2	Homo sapiens	34-37
12628520-1	2003	The carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure to dietary phytochemicals, such as the water-soluble derivative of chlorophyll called chlorophyllin.	Water	258-263	catenin beta 1	Rattus norvegicus	150-162
29859956-3	2018	Here, we report the results of using dogs for quantitative Fah prediction, focusing on poorly water-soluble free acid and neutral drugs.	Water	94-99	FAH	Canis lupus familiaris	59-62
30067239-7	2018	Mean per-capita tap water intake across the entire Japanese population was estimated at 1.28 L/d, whereas mean pTWI was estimated at 1.65 L/d.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
29752024-12	2018	Individuals using treated water for drinking or using own tap as the source of water were more likely to receive the OCV (aOR: 1.23; 95% CI = 1.17-1.29 and aOR: 1.14; 95% CI = 1.02-1.25 respectively) than their counterpart.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	58-61
12566588-9	2003	Together, our data provide evidence for the contribution of a single aquaporin gene to root water uptake and identify PIP2;2 as an aquaporin specialized in osmotic fluid transport.	Water	92-97	plasma membrane intrinsic protein 2	Arabidopsis thaliana	118-124
30087563-7	2018	The fabricated Hy-entrapped glyconanoparticle (Lac-PHM) exhibited excellent water dispersibility, stability, and selectivity for asialoglycoprotein receptors overexpressing HepG2 cells.	Water	76-81	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	51-54
29984561-4	2018	Probe Hg-P was used in real water and soil solution samples to detect Hg2+ , and the result is satisfactory.	Water	28-33	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	70-73
29660725-3	2018	However, people are exposed to tap water inside the house while water may stay in the plumbing premise for several hours prior to reaching the tap.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
29660725-3	2018	However, people are exposed to tap water inside the house while water may stay in the plumbing premise for several hours prior to reaching the tap.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	143-146
29660725-3	2018	However, people are exposed to tap water inside the house while water may stay in the plumbing premise for several hours prior to reaching the tap.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	143-146
29660725-4	2018	Depending on stagnation period and plumbing premise, concentrations of Pb in tap water can be significantly higher than the WDS leading to higher intake of Pb than the values from WDS or WTP.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
29660725-13	2018	The models can be used for predicting Pb in tap water, which can assist to better protect the humans.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
29710648-5	2018	In addition, significantly higher PFAS levels were found in river-originating tap water than in lake/reservoir-originating tap water (Mann-Whitney U test, p&lt;0.05).	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
29710648-5	2018	In addition, significantly higher PFAS levels were found in river-originating tap water than in lake/reservoir-originating tap water (Mann-Whitney U test, p&lt;0.05).	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
30036962-0	2018	Effectiveness of Prevailing Flush Guidelines to Prevent Exposure to Lead in Tap Water.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
30036962-1	2018	Flushing tap water is promoted as a low cost approach to reducing water lead exposures.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
12544850-2	2003	Compared with non-transgenic littermates, male 14-month-old APP + PS1 mice were impaired in spatial learning in the water maze.	Water	116-121	presenilin 1	Mus musculus	66-69
29710648-7	2018	Finally, the average human exposure via tap water consumption was estimated for PFASs (46.8ng/person/day) and OPFRs (254ng/person/day).	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
30252663-1	2018	In this study, for the first time, the influence of the design of conventional membrane diffusers on the volumetric mass transfer coefficient (kLa) and bubble size in tap water (TW) and saline water (SW) was investigated (up to 15 g/L NaCl).	Water	171-176	nuclear RNA export factor 1	Homo sapiens	167-170
12527621-2	2003	Myocardial ischemia/reperfusion that occurs with CPB/CPA activates the Na(+)/H(+) exchanger to normalize intracellular pH, with intracellular Na(+) (and water) accumulation.	Water	153-158	solute carrier family 9 member A1	Canis lupus familiaris	71-91
30214897-9	2018	The characterization techniques utilized confirmed the formation of the inclusion complex, HPbetaCD:17-AAG, with a resulting 33-fold-enhancement in compound water solubility.	Water	157-162	nitrogen permease regulator-like 3	Mus musculus	103-106
29714400-4	2018	When this bifunctional catalyst was further used for H2 and O2 production in an electrochemical water-splitting unit, it can operate in ambient conditions with a competitive gas production rate of 1.15 and 0.57 muL s-1 for hydrogen and oxygen, respectively, showing its potential for practical applications.	Water	96-101	relaxin 2	Homo sapiens	53-62
12669273-1	2003	Aquaporin-2, a water-channel protein, is known to increase water permeability due to vasopressin binding to V2 receptors at the renal collecting duct and is excreted into the urine.	Water	15-20	aquaporin 2	Homo sapiens	0-11
30022811-3	2018	Objectives: In order to improve the dissolution rate and increase oral relative bioavailability of the poorly water-soluble drugs, a tin oxide carrier (MSn) with a mesoporous structure was successfully synthesized.	Water	110-115	moesin	Oryctolagus cuniculus	152-155
29672207-2	2018	In this paper, the degradation of PPB by aqueous ferrate (Fe(VI)) was investigated in different water matrix and reaction kinetics as a function of pH was determined.	Water	96-101	histatin 1	Homo sapiens	34-37
29672207-4	2018	Acute and chronic toxicities during water treatment of PPB using Fe(VI) were calculated using the ECOSAR program at three trophic levels.	Water	36-41	histatin 1	Homo sapiens	55-58
14520006-2	2003	We studied the potential protective effect of the water-soluble PARP inhibitor 3-aminobenzamide (3-AB) in a rat model of acute renal failure (ARF) from combined administration of radiocontrast, indomethacin and N(omega)-nitro-L-arginine methyl ester.	Water	50-55	poly (ADP-ribose) polymerase 1	Rattus norvegicus	64-68
30151061-1	2018	A novel, stimuli-responsive composite, based on poly(4-vinylpyridine) (PVP) brushes, end-grafted to montmorillonite clay (GPC), was designed as a regenerable sorbent for efficient removal of pollutants from water.	Water	207-212	glycophorin C (Gerbich blood group)	Homo sapiens	122-125
29979588-2	2018	In this work, we focus on the conjugation of amphiphilic variants of elastin-like polypeptide (ELP), short elastin (sEL), to poorly water-soluble compounds like OPPVs ( p-phenylenevinylene oligomers), triarylamines, and polypyridine-metal complexes.	Water	132-137	elastin	Homo sapiens	69-76
29665253-5	2018	Additionally, the CNF network significantly enhances the wetting ability of initial hydrophobic reduced GO nanosheets, allowing fast water transport combined with high filtration efficiency.	Water	133-138	NPHS1 adhesion molecule, nephrin	Homo sapiens	18-21
29714817-2	2018	Herein, we explore the potential of an ethidium bromide (EB)-based covalent organic framework (EB-TFP) that self-exfoliates in water resulting in 2D ionic covalent organic nanosheets (EB-TFP-iCONs) for the selective detection of double-stranded DNA (dsDNA).	Water	127-132	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	98-101
29946030-3	2018	We apply these methods to report here the folded structure in water from a fully extended chain of tropoelastin, a 698-amino acid molecular precursor to elastic fibers that confer elasticity and recoil to tissues, finding good agreement with experimental data.	Water	62-67	elastin	Homo sapiens	99-111
12608547-0	2003	Oral-antigen delivery via a water-in-oil emulsion system modulates the balance of the Th1/Th2 type response in oral tolerance.	Water	28-33	heart and neural crest derivatives expressed 2	Mus musculus	90-93
31458899-0	2018	Water Mobility within Compacted Clay Samples: Multi-Scale Analysis Exploiting 1H NMR Pulsed Gradient Spin Echo and Magnetic Resonance Imaging of Water Density Profiles.	Water	0-5	spindlin 1	Homo sapiens	101-105
30033030-3	2018	The data suggest that increased presence of CD11b+ myeloid cells in the medulla might explain intensified salt and water retention as well as initial hypertensive response in Rag1-/- mice.	Water	115-120	integrin subunit alpha M	Homo sapiens	44-49
12442202-8	2003	Expression of c-Fos was significantly higher in the alcohol/sucrose group than both the water and sucrose groups in the Edinger-Westphal nucleus, and significantly lower in the alcohol/sucrose group than two control groups in hippocampal subregions, posterior hypothalamus and dorsal lateral septum.	Water	88-93	FBJ osteosarcoma oncogene	Mus musculus	14-19
29751100-4	2018	This reduction in AQP5 expression impairs water permeability and therefore results in hypo-salivation.	Water	42-47	aquaporin 5	Mus musculus	18-22
30022991-3	2018	In Arabidopsis, STOMATAL DENSITY AND DISTRIBUTION 1 (AtSDD1) negatively regulates stomatal density and optimizes transpiration and water use efficiency (WUE).	Water	131-136	Subtilase family protein	Arabidopsis thaliana	16-51
30022991-3	2018	In Arabidopsis, STOMATAL DENSITY AND DISTRIBUTION 1 (AtSDD1) negatively regulates stomatal density and optimizes transpiration and water use efficiency (WUE).	Water	131-136	Subtilase family protein	Arabidopsis thaliana	53-59
12452690-0	2002	1H NMR detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1.	Water	32-37	heme oxygenase 1	Homo sapiens	121-137
29733595-0	2018	Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase.	Water	0-5	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	121-160
30310628-5	2018	Our results revealed that actinide aquo ions, An(H2O) x 3+ (x = 9.6 +- 0.7, 8.9 +- 0.8, and 10.0 +- 0.9 for CmIII, AmIII, and AcIII), were the dominant species in dilute HNO3 (0.05 M).	Water	49-52	adenylate cyclase 3	Homo sapiens	126-131
12444076-3	2002	Binding of ligands to GC-C leads to accumulation of intracellular cGMP, the activation of protein kinases G and A, and phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel that regulates salt and water secretion.	Water	245-250	CF transmembrane conductance regulator	Rattus norvegicus	142-193
29684495-7	2018	The ranking order of metals concentrations in the tap drinking water was Zn &gt; Pb &gt; As &gt; Co &gt; Hg.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	50-53
29806512-1	2018	Autoantibodies targeting aquaporin 4 (AQP4) water channels are a sensitive and specific biomarker for neuromyelitis optica spectrum disorder (NMOSD).	Water	44-49	aquaporin 4	Homo sapiens	25-36
29806512-1	2018	Autoantibodies targeting aquaporin 4 (AQP4) water channels are a sensitive and specific biomarker for neuromyelitis optica spectrum disorder (NMOSD).	Water	44-49	aquaporin 4	Homo sapiens	38-42
30269461-7	2018	All the zinc complexes had lower anti-tyrosinase activity than their extracts, while the manganese com- plex of the water and absolute ethanol extracts exhibited higher anti-tyrosinase activity than related extracts.	Water	116-121	tyrosinase	Homo sapiens	174-184
29725924-0	2018	The predominant phytoplankton of Pseudoanabaena holding specific biosynthesis gene-derived occurrence of 2-MIB in a drinking water reservoir.	Water	125-130	MIB E3 ubiquitin protein ligase 1	Homo sapiens	107-110
12444076-3	2002	Binding of ligands to GC-C leads to accumulation of intracellular cGMP, the activation of protein kinases G and A, and phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel that regulates salt and water secretion.	Water	245-250	CF transmembrane conductance regulator	Rattus norvegicus	195-199
29924440-4	2018	After replacing ethanol with water, the morphologies of these assemblies remain unchanged, while their size decreases due to the collapse of the hydrophobic PDEA chains.	Water	29-34	phosphodiesterase 6A	Homo sapiens	157-161
12499594-2	2002	The use of log k derived from reversed phase (RP)-HPLC retention times provides a convenient method for estimating log P(oct) values (P(oct): 1-octanol/water partition coefficient).	Water	152-157	plexin A2	Homo sapiens	121-124
30082812-6	2018	However, after leaving drinking water treatment plants, corrosion by-products released from distribution pipes or in-home premise plumbing can release incidental nanoparticles into tap water.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	181-184
29154923-1	2018	Aquaporin-4 (AQP4) is abundantly expressed in the central nervous system and is involved in the water balance in the cellular environment.	Water	96-101	aquaporin 4	Mus musculus	0-11
29154923-1	2018	Aquaporin-4 (AQP4) is abundantly expressed in the central nervous system and is involved in the water balance in the cellular environment.	Water	96-101	aquaporin 4	Mus musculus	13-17
29154923-8	2018	The contradictory results suggest that changes in AQP4 may be context-dependent and further studies are required to understand the precise contribution of brain water balance in ALS.	Water	161-166	aquaporin 4	Mus musculus	50-54
29803496-8	2018	We observed that water CST extracts are rich in phenolic content, whereas for CTA the olive oil was the elective extraction solvent.	Water	17-22	cystatin 12, pseudogene	Homo sapiens	23-26
29803496-9	2018	As expected, water CST extracts were the most effective in reducing hydrogen peroxide-induced oxidative stress in both cell lines and in vitro assays.	Water	13-18	cystatin 12, pseudogene	Homo sapiens	19-22
29543692-6	2018	The new X-map ("X-map 2.0") estimated regional GM values-thus, maximizing the ability to suppress the GM-WM contrast, make edema signals quantitative, and enhance the edema signals that denote an increased water density for each pixel.	Water	206-211	microtubule associated protein 2	Homo sapiens	18-23
12444982-5	2002	HSP60 mRNA was increased in the kidney papilla of rats that had been water restricted for three and five days, but no changes in HSP60 mRNA were detected in the cortex or the medulla of the rat kidneys.	Water	69-74	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	0-5
29214470-2	2018	Spa water contains mineral components which lower the specific heat of the water, resulting in a higher efficiency to warm body-core temperature.	Water	4-9	surfactant protein A2	Homo sapiens	0-3
29214470-2	2018	Spa water contains mineral components which lower the specific heat of the water, resulting in a higher efficiency to warm body-core temperature.	Water	75-80	surfactant protein A2	Homo sapiens	0-3
29924611-7	2018	The water moiety with the H3O+ ion core resides on the phenyl ring, and the water moiety is bound to the phenyl ring with a pi-hydrogen bond.	Water	4-9	H3 clustered histone 15	Homo sapiens	26-29
29924611-7	2018	The water moiety with the H3O+ ion core resides on the phenyl ring, and the water moiety is bound to the phenyl ring with a pi-hydrogen bond.	Water	76-81	H3 clustered histone 15	Homo sapiens	26-29
12444982-7	2002	HSP60 was remarkably decreased in the kidney papilla of rats that were water restricted but the protein was increased in the mitochondria of the rat kidney papilla.	Water	71-76	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	0-5
29977067-1	2018	Previous studies showed that restraint water-immersion stress (RWIS) increases the expression of Fos protein in the ventromedial hypothalamic nucleus (VMH), indicating the VMH involving in the stress-induced gastric mucosal injury (SGMI).	Water	39-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-100
12432032-1	2002	The interrelationship among water-stress-induced abscisic acid (ABA) accumulation, the generation of reactive oxygen species (ROS), and the activities of several antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and glutathione reductase (GR) was investigated in leaves of detached maize (Zea mays L.) plants exposed to -0.7 MPa water stress induced by polyethylene glycol (PEG 6000).	Water	28-33	glutathione reductase 1	Zea mays	266-287
29669219-1	2018	Intestinal absorption of the water-soluble vitamins biotin and pantothenic acid is carrier mediated and involves the sodium-dependent multivitamin transporter (SMVT; product of the SLC5A6 gene).	Water	29-34	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	Mus musculus	117-158
29669219-1	2018	Intestinal absorption of the water-soluble vitamins biotin and pantothenic acid is carrier mediated and involves the sodium-dependent multivitamin transporter (SMVT; product of the SLC5A6 gene).	Water	29-34	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	Mus musculus	160-164
29875071-1	2018	The presence of water disinfection byproducts (DBPs) in tap water, resulting from disinfection processes involving chlorination or chloramination, increases the mutagenicity of the water and may pose adverse health effects.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	56-59
29608988-3	2018	Recently, the glymphatic system was discovered, in which cerebrospinal fluid is exchanged with interstitial fluid, facilitated by the aquaporin-4 water channels on the astroglial endfeet.	Water	146-151	aquaporin 4	Homo sapiens	134-145
29669219-1	2018	Intestinal absorption of the water-soluble vitamins biotin and pantothenic acid is carrier mediated and involves the sodium-dependent multivitamin transporter (SMVT; product of the SLC5A6 gene).	Water	29-34	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	Mus musculus	181-187
12432032-1	2002	The interrelationship among water-stress-induced abscisic acid (ABA) accumulation, the generation of reactive oxygen species (ROS), and the activities of several antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and glutathione reductase (GR) was investigated in leaves of detached maize (Zea mays L.) plants exposed to -0.7 MPa water stress induced by polyethylene glycol (PEG 6000).	Water	28-33	glutathione reductase 1	Zea mays	289-291
31949707-5	2018	The aim of this research was to investigate whether the function of IL-17 influenced hepatocyte-induced H2O2.	Water	104-108	interleukin 17A	Homo sapiens	68-73
31949707-6	2018	We found that the expression of IL-17 was enhanced in hepatocyte-induced H2O2 and that IL-17 was down-regulated by siRNA.	Water	73-77	interleukin 17A	Homo sapiens	32-37
29573632-1	2018	The general consensus is that the abundance of tap water bacteria is greatly influenced by water purification and distribution.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
12441994-17	2002	H2O for 7 hours in serum-free DMEM resulted in a time dependent decrease in MMP-1, 2 and 9 activity (15%, 37% and 25%) compared to controls maintained at atmospheric pressure (p &lt;0.01).	Water	0-3	matrix metallopeptidase 1	Homo sapiens	76-90
12297371-9	2002	Thus, the treatment with DCP and PQ in water changed the properties of the mussels digestive gland cytochrome P450 monooxygenase system.	Water	39-44	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	99-128
29573632-1	2018	The general consensus is that the abundance of tap water bacteria is greatly influenced by water purification and distribution.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	47-50
29573632-3	2018	For the first time, this full-scale study has captured and identified the proportional contribution of the source water, treated water, and distribution system in shaping the tap water bacterial community based on their microbial community fingerprints using the Bayesian "SourceTracker" method.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	175-178
29573632-3	2018	For the first time, this full-scale study has captured and identified the proportional contribution of the source water, treated water, and distribution system in shaping the tap water bacterial community based on their microbial community fingerprints using the Bayesian "SourceTracker" method.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	175-178
29573632-3	2018	For the first time, this full-scale study has captured and identified the proportional contribution of the source water, treated water, and distribution system in shaping the tap water bacterial community based on their microbial community fingerprints using the Bayesian "SourceTracker" method.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	175-178
12372793-1	2002	AVP increases the osmotic water permeability of renal collecting ducts by inducing the translocation of specific aquaporin-2 (AQP2) water channels from cytoplasmic vesicles to the apical plasma membrane of the principal cells.	Water	26-31	aquaporin 2	Rattus norvegicus	126-130
29573632-7	2018	The planktonic bacteria in the treated water was the major contributor to planktonic bacteria in the tap water (17.7-54.1%).	Water	39-44	nuclear RNA export factor 1	Homo sapiens	101-104
29573632-9	2018	In return, the loose deposits and biofilm showed a significant influence on tap water planktonic and particle-associated bacteria, which were location dependent and influenced by hydraulic changes.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
29573632-10	2018	This was revealed by the increased contribution of loose deposits to tap water planktonic bacteria (from 2.5% to 38.0%) and an increased contribution of biofilm to tap water particle-associated bacteria (from 5.9% to 19.7%) caused by possible hydraulic disturbance from proximal to distal regions.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
29573632-11	2018	Therefore, our findings indicate that the tap water bacteria could possibly be managed by selecting and operating the purification process properly and cleaning the distribution system effectively.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
12372793-1	2002	AVP increases the osmotic water permeability of renal collecting ducts by inducing the translocation of specific aquaporin-2 (AQP2) water channels from cytoplasmic vesicles to the apical plasma membrane of the principal cells.	Water	132-137	aquaporin 2	Rattus norvegicus	113-124
12372793-1	2002	AVP increases the osmotic water permeability of renal collecting ducts by inducing the translocation of specific aquaporin-2 (AQP2) water channels from cytoplasmic vesicles to the apical plasma membrane of the principal cells.	Water	132-137	aquaporin 2	Rattus norvegicus	126-130
12194985-1	2002	In renal collecting ducts, a vasopressin-induced cAMP increase results in the phosphorylation of aquaporin-2 (AQP2) water channels at Ser-256 and its redistribution from intracellular vesicles to the apical membrane.	Water	116-121	aquaporin 2	Canis lupus familiaris	110-114
29933362-7	2018	ASE risk was 3.6% with whole tablets, 25.4% with crushed tablets, and 34.6% when crushed tablets were mixed with water.	Water	113-118	arylsulfatase L	Homo sapiens	0-3
29933362-8	2018	In multivariate analysis, ASE risk was significantly associated with children 1 year (OR 2.7) or 2 years (OR 2.9) of age; male gender (OR 1.6); non-content child demeanor (fearful, fussy, or combative) before albendazole administration (OR 4.3); child struggling when given albendazole (OR 2.1); and giving water, either after the tablet or mixed with it (OR 5.8).	Water	307-312	arylsulfatase L	Homo sapiens	26-29
12483228-5	2002	The modeled conformation of the loop was validated by unconstrained MD simulations of the complete enzymes (CYP2C5 and CYP2B6) in water for 70 and 120 ps, respectively.	Water	130-135	cytochrome P450 2C5	Oryctolagus cuniculus	108-114
32254314-6	2018	Other advantages of TGP@MOS-ZnPc include excellent water solubility, stability, hemocompatibility and biocompatibility.	Water	51-56	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	24-27
12444369-1	2002	BACKGROUND: This study was designed to investigate the effects of 5-aminoisoquinolinone (5-AIQ), a water-soluble potent inhibitor of poly-(ADP-ribose) polymerase (PARP) in a rat model of liver ischemia-reperfusion injury.	Water	99-104	poly (ADP-ribose) polymerase 1	Rattus norvegicus	133-161
29799193-4	2018	In this study, the CAPE/PLGA NPs were synthesized using an oil-in-water (o/w) single-emulsion solvent evaporation method with an average size of 206.2 +- 1.2 nm, zeta potential of -19.8 +- 2.5 mV, encapsulation efficiency of 87.2 +- 2.5%, and drug loading of 53.3 +- 1.8%.	Water	66-71	structural maintenance of chromosomes 2	Homo sapiens	19-32
12444369-1	2002	BACKGROUND: This study was designed to investigate the effects of 5-aminoisoquinolinone (5-AIQ), a water-soluble potent inhibitor of poly-(ADP-ribose) polymerase (PARP) in a rat model of liver ischemia-reperfusion injury.	Water	99-104	poly (ADP-ribose) polymerase 1	Rattus norvegicus	163-167
12444369-11	2002	CONCLUSIONS: Taken together, these results show that 5-AIQ, a new water-soluble potent inhibitor of poly-(ADP-ribose) polymerase, reduces the tissue injury associated with ischemia-reperfusion of the liver.	Water	66-71	poly (ADP-ribose) polymerase 1	Rattus norvegicus	100-128
29992101-5	2018	For tap water, satisfying flocculation efficiencies (above 60 %) were only reached for autoclaved water samples.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
12419640-1	2002	The neurohormonal factor arginine vasopressin (AVP) produces potent systemic vasoconstriction as well as water retention in the kidneys via the V(1a) and V(2) receptors, respectively.	Water	105-110	arginine vasopressin	Canis lupus familiaris	47-50
29992101-5	2018	For tap water, satisfying flocculation efficiencies (above 60 %) were only reached for autoclaved water samples.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	4-7
12462587-0	2002	Preliminary investigation of the mercury saturation in the Baltic Sea winter surface water.	Water	85-90	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	66-69
29971013-11	2018	Research in this area is complicated by the fact that the H2O/CO2-transporting function of AQP1 is replaceable by other erythrocyte channels/transporters (e.g., UT-B/GLUT1 for H2O; RhAG for CO2).	Water	176-179	solute carrier family 2 member 1	Homo sapiens	166-171
29971013-12	2018	Recently, using carbonic anhydrase II (CAII)-filled erythrocyte vesicles, AQP1 has been demonstrated to transport water for the CAII-mediated reaction, CO2(g) + H2O   HCO3-(aq) + H+(aq).	Water	114-119	carbonic anhydrase 2	Homo sapiens	16-37
29971013-12	2018	Recently, using carbonic anhydrase II (CAII)-filled erythrocyte vesicles, AQP1 has been demonstrated to transport water for the CAII-mediated reaction, CO2(g) + H2O   HCO3-(aq) + H+(aq).	Water	114-119	carbonic anhydrase 2	Homo sapiens	39-43
29971013-12	2018	Recently, using carbonic anhydrase II (CAII)-filled erythrocyte vesicles, AQP1 has been demonstrated to transport water for the CAII-mediated reaction, CO2(g) + H2O   HCO3-(aq) + H+(aq).	Water	114-119	carbonic anhydrase 2	Homo sapiens	128-132
29971013-12	2018	Recently, using carbonic anhydrase II (CAII)-filled erythrocyte vesicles, AQP1 has been demonstrated to transport water for the CAII-mediated reaction, CO2(g) + H2O   HCO3-(aq) + H+(aq).	Water	161-164	carbonic anhydrase 2	Homo sapiens	16-37
29971013-12	2018	Recently, using carbonic anhydrase II (CAII)-filled erythrocyte vesicles, AQP1 has been demonstrated to transport water for the CAII-mediated reaction, CO2(g) + H2O   HCO3-(aq) + H+(aq).	Water	161-164	carbonic anhydrase 2	Homo sapiens	39-43
29971013-12	2018	Recently, using carbonic anhydrase II (CAII)-filled erythrocyte vesicles, AQP1 has been demonstrated to transport water for the CAII-mediated reaction, CO2(g) + H2O   HCO3-(aq) + H+(aq).	Water	161-164	carbonic anhydrase 2	Homo sapiens	128-132
12462587-1	2002	A new experimental measuring system for the total gaseous mercury saturation in the sea surface water has been developed.	Water	96-101	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	84-87
12462587-2	2002	The technique applied to the system is based on equilibrating water-air mercury partial pressures at the air-sea interface.	Water	62-67	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
12270612-1	2002	Cisplatin (cis-DDP) is subject to nucleophilic displacement of chloride in water, forming aquated species, subsequently liberating hydrogen ion(s) with increasing pH.	Water	75-80	translocase of inner mitochondrial membrane 8A	Homo sapiens	15-18
29912865-7	2018	In CXCR4, the sodium ion is tightly bound by four protein atoms and one water molecule.	Water	72-77	C-X-C motif chemokine receptor 4	Homo sapiens	3-8
29912865-8	2018	In CCR5, the sodium ion is mobile within the binding pocket and moves between different sites involving from one to three protein atoms and two to five water molecules.	Water	152-157	C-C motif chemokine receptor 5	Homo sapiens	3-7
12351872-2	2002	With HbC, a strong retrograde solubility dependence on temperature yields a high positive enthalpy of 155 kJ mol(-1), i.e., crystallization is only possible because of the huge entropy gain of 610 J mol(-1) x K(-1), stemming from the release of up to 10 water molecules per protein intermolecular contact.	Water	254-259	keratin 88, pseudogene	Homo sapiens	5-8
28869054-4	2018	There are many areas of the world that have excessive fluoride in drinking water, such as China, India, Sri Lanka, and the Rift Valley countries in Africa.	Water	75-80	sorcin	Homo sapiens	104-107
12479572-6	2002	These results demonstrate that E-FABP is responsible for the water permeability barrier of the skin, although the molecular mechanism remains to be further elucidated.	Water	61-66	fatty acid binding protein 5, epidermal	Mus musculus	31-37
29529460-6	2018	However, acid treatment of CNF (F-CNF), which resulted in the shortening of the fibers and the appearance of surface-oxygenated species, made F-CNF-based nanofluids exhibit superior stability in water that extended for more than 90 days, with consistent and superior thermal and electrical properties.	Water	195-200	NPHS1 adhesion molecule, nephrin	Homo sapiens	27-30
29529460-6	2018	However, acid treatment of CNF (F-CNF), which resulted in the shortening of the fibers and the appearance of surface-oxygenated species, made F-CNF-based nanofluids exhibit superior stability in water that extended for more than 90 days, with consistent and superior thermal and electrical properties.	Water	195-200	NPHS1 adhesion molecule, nephrin	Homo sapiens	32-37
29529460-6	2018	However, acid treatment of CNF (F-CNF), which resulted in the shortening of the fibers and the appearance of surface-oxygenated species, made F-CNF-based nanofluids exhibit superior stability in water that extended for more than 90 days, with consistent and superior thermal and electrical properties.	Water	195-200	NPHS1 adhesion molecule, nephrin	Homo sapiens	142-147
12422412-0	2002	Immunohistochemical characterization of the intracellular pool of water channel aquaporin-2 in the rat kidney.	Water	66-71	aquaporin 2	Rattus norvegicus	80-91
29763313-10	2018	The solubility of water in the [DoMIM][NTf2] is quite high in comparison with that measured by us earlier for ILs ( x3 = 0.403) at T = 308.15 K, which results in not very successful average selectivity of extraction of PEA from the aqueous phase.	Water	18-23	nuclear transport factor 2	Homo sapiens	39-43
29907021-4	2018	Here we develop classical non-polarizable force fields for the aqueous alkaline earth metal halides (MX2), where M = Mg2+, Ca2+, Sr2+, Ba2+ and X = Cl-, Br-, I-, which can be used in bimolecular simulations and which are compatible with the Simple Point Charge/Extended (SPC/E) water model.	Water	278-283	MX dynamin like GTPase 2	Homo sapiens	101-104
12440767-4	2002	The other components of the respiratory-burst oxidase are water-soluble proteins of cytosolic origin, namely p67phox, p47phox, p40phox and Rac.	Water	58-63	neutrophil cytosolic factor 4	Homo sapiens	127-142
29761801-3	2018	In fact, the co-production of H2 and O2 in conventional water electrolysis may result in the formation of explosive H2/O2 gas mixtures due to gas crossover and reactive oxygen species (ROS); both pose safety concerns and shorten the lifetimes of water splitting cells.	Water	56-61	relaxin 2	Homo sapiens	30-39
29761801-3	2018	In fact, the co-production of H2 and O2 in conventional water electrolysis may result in the formation of explosive H2/O2 gas mixtures due to gas crossover and reactive oxygen species (ROS); both pose safety concerns and shorten the lifetimes of water splitting cells.	Water	246-251	relaxin 2	Homo sapiens	30-39
12391854-0	2002	[Conformational states of the water-soluble fragment of cytochrome b5.	Water	30-35	cytochrome b5 type A	Homo sapiens	56-69
29729279-4	2018	Bovine and human CAII and CAIV have been reported to exert nitrite reductase and nitrous anhydride activity: 2 NO2- + 2 H+   [2 HONO]   N2O3 + H2O.	Water	143-146	carbonic anhydrase 2	Homo sapiens	17-21
12391854-2	2002	Cytochrome b5 is a membrane protein that comprises two fragments: one is water-soluble and heme-containing, and the other is hydrophobic and membrane-embedded.	Water	73-78	cytochrome b5 type A	Homo sapiens	0-13
12391854-5	2002	The current study describes the conformational behavior of the negatively charged water-soluble fragment of cytochrome b5 as dependent on pH.	Water	82-87	cytochrome b5 type A	Homo sapiens	108-121
29613984-2	2018	T2-weighted Dixon turbo spin echo (TSE) enables the generation of T2-weighted fat- and water-separated images, which can be used to assess both pathologies simultaneously.	Water	87-92	spindlin 1	Homo sapiens	24-28
29325460-1	2018	Melittin, a small water-soluble cationic amphipathic alpha-helical linear peptide, consisted of 26 amino acids, is the honeybee venom major constituent.	Water	18-23	melittin	Apis mellifera	0-8
29608911-2	2018	Aquaporin-4 (AQP-4) is a membrane bound water channel protein that plays a distinct role in water reabsorption from renal tubular fluid.	Water	40-45	aquaporin 4	Mus musculus	0-11
12039961-4	2002	Surprisingly, for hGIIA bound to anionic vesicles, all of the spin labels were highly protected from water-soluble spin relaxants.	Water	101-106	glucosidase II alpha subunit	Homo sapiens	18-23
29608911-2	2018	Aquaporin-4 (AQP-4) is a membrane bound water channel protein that plays a distinct role in water reabsorption from renal tubular fluid.	Water	40-45	aquaporin 4	Mus musculus	13-18
30533993-1	2018	Introduction and Objectives: Tap water iontophoresis is a promising therapy for palmoplantar hyperhidrosis.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
30123560-0	2018	ALK inhibitors and checkpoint blockade: a cautionary tale of mixing oil with water?	Water	77-82	ALK receptor tyrosine kinase	Homo sapiens	0-3
29608911-2	2018	Aquaporin-4 (AQP-4) is a membrane bound water channel protein that plays a distinct role in water reabsorption from renal tubular fluid.	Water	92-97	aquaporin 4	Mus musculus	0-11
12176047-1	2002	Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel in the kidney collecting duct.	Water	47-52	aquaporin 2	Rattus norvegicus	0-11
29608911-2	2018	Aquaporin-4 (AQP-4) is a membrane bound water channel protein that plays a distinct role in water reabsorption from renal tubular fluid.	Water	92-97	aquaporin 4	Mus musculus	13-18
29608911-5	2018	We hypothesize that impaired water reabsorption leads to renal injury in HIVAN, where AQP-4 plays a crucial role.	Water	29-34	aquaporin 4	Mus musculus	86-91
29608911-11	2018	We provide the first evidence that AQP-4 is inhibited due to induction of HIV associated stress in the kidneys of TG26 mice which limits water reabsorption in the kidney which may be one of the cause associated with HIVAN, impairing kidney physiology.	Water	137-142	aquaporin 4	Mus musculus	35-40
29220098-0	2018	Trace analysis in water-alcohol mixtures by continuous p-H2 hyperpolarization at high magnetic field.	Water	18-23	polyhomeotic homolog 2	Homo sapiens	55-59
12176047-1	2002	Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel in the kidney collecting duct.	Water	47-52	aquaporin 2	Rattus norvegicus	13-18
12110515-0	2002	Water permeability of aquaporin-4 is decreased by protein kinase C and dopamine.	Water	0-5	aquaporin 4	Sus scrofa	22-33
29695157-8	2018	T2 relaxation nuclear magnetic resonance and small angle X-ray scattering together support the hypothesis that binding of IMP to PMM1 favors an enzyme conformation that is catalytically competent for water attack at the phosphoaspartyl intermediate.	Water	200-205	phosphomannomutase 1	Homo sapiens	129-133
29801806-5	2018	As intracellular water content of S. cerevisiae strain 14 (a strain with moderate tolerance to dehydration-rehydration) was reduced to 1.5 g water/g dry weight, the activity of the Agt1 transporter decreased by 10-15 %.	Water	141-146	alpha-glucoside permease	Saccharomyces cerevisiae S288C	181-185
29768237-4	2018	Furthermore, the CNF/MWCNT carbon aerogels (CMCA) can be recycled many times by distillation and combustion, satisfying the requirements of practical oil-water separation.	Water	154-159	NPHS1 adhesion molecule, nephrin	Homo sapiens	17-20
12110515-1	2002	Aquaporin-4 (AQP4) plays an important role in the basolateral movement of water in the collecting duct.	Water	74-79	aquaporin 4	Sus scrofa	0-11
12110515-1	2002	Aquaporin-4 (AQP4) plays an important role in the basolateral movement of water in the collecting duct.	Water	74-79	aquaporin 4	Sus scrofa	13-17
29950573-2	2018	Glass microspheres were found to decrease the spin-spin relaxation time (T2) of water protons in the gels, which was interpreted as enhanced water binding by the glass.	Water	80-85	spindlin 1	Homo sapiens	46-50
12110515-3	2002	Water permeability (P(f)) was measured in individual LLC-PK1 cells that were transiently transfected with AQP4.	Water	0-5	aquaporin 4	Sus scrofa	106-110
29950573-2	2018	Glass microspheres were found to decrease the spin-spin relaxation time (T2) of water protons in the gels, which was interpreted as enhanced water binding by the glass.	Water	80-85	spindlin 1	Homo sapiens	51-55
29950573-2	2018	Glass microspheres were found to decrease the spin-spin relaxation time (T2) of water protons in the gels, which was interpreted as enhanced water binding by the glass.	Water	141-146	spindlin 1	Homo sapiens	46-50
29522679-3	2018	In this Article, we present a detailed picture for the folding of the inhibitor peptide PMI into a helix during binding to the oncoprotein fragment 25-109Mdm2 obtained from atomistic, explicit-water simulations and Markov state modeling.	Water	193-198	transmembrane protein 11	Homo sapiens	88-91
12110515-10	2002	Reduction of AQP4 water permeability by PDBu and dopamine was abolished by point mutation of Ser(180), a consensus site for PKC phosphorylation.	Water	18-23	aquaporin 4	Sus scrofa	13-17
29950573-2	2018	Glass microspheres were found to decrease the spin-spin relaxation time (T2) of water protons in the gels, which was interpreted as enhanced water binding by the glass.	Water	141-146	spindlin 1	Homo sapiens	51-55
12110515-11	2002	We conclude that PKC and dopamine decrease AQP4 water permeability via phosphorylation at Ser180 and that the effect is likely mediated by gating of the channel.	Water	48-53	aquaporin 4	Sus scrofa	43-47
12095869-1	2002	This study investigated the mRNA expression of the atrial natriuretic peptide (ANP) system (peptide and receptors) during water deprivation in the spinifex hopping mouse, Notomys alexis, a native of central and western Australia that is well adapted to survive in arid environments.	Water	122-127	natriuretic peptide type A	Mus musculus	79-82
29847117-5	2018	Meanwhile, it showed good selectivity and has been applied to detecting Hg2+ in tap water and milk samples with good precision.	Water	84-89	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	72-75
29920519-18	2018	The Pdc estimated by the multi-drop method is ~ 11-fold higher than previously reported but closer to the value reported for other drugs with equivalent octanol/water partition coefficient.	Water	161-166	phosducin	Homo sapiens	4-7
29785426-1	2018	Recent experiments have shown that complex (1), [Fe(OTf)2(Pytacn)] (OTf = CF3SO3-, Pytacn = 1-(2"-pyridylmethyl)-4,7-dimethyl-1,4,7-triazacyclononane), is a promising artificial photosynthetic catalyst because of its distinct capability in water oxidation.	Water	240-245	POU class 2 homeobox 2	Homo sapiens	52-57
29896189-5	2018	Quantitative RT-PCR demonstrated that gtfP was significantly up-regulated in DeltabrpL, which increased the productions of water-insoluble and water-soluble glucans.	Water	123-128	glucosyltransferase	Streptococcus sanguinis SK36	38-42
12095869-4	2002	The levels of ANP mRNA expression in the heart remained unchanged, but in the kidney ANP mRNA levels were increased in the 7-day water-deprived mice, and were significantly decreased in the 14-day water-deprived mice.	Water	129-134	natriuretic peptide type A	Mus musculus	85-88
29896189-5	2018	Quantitative RT-PCR demonstrated that gtfP was significantly up-regulated in DeltabrpL, which increased the productions of water-insoluble and water-soluble glucans.	Water	143-148	glucosyltransferase	Streptococcus sanguinis SK36	38-42
29973905-3	2018	AQP4 is the main water channel protein in the central nervous system, but has also been identified in the female reproductive system.	Water	17-22	aquaporin 4	Homo sapiens	0-4
12095869-7	2002	This study shows that water deprivation differentially affects the expression of the ANP system, and that renal ANP expression is more important than cardiac ANP in the physiological adjustment to water deprivation.	Water	22-27	natriuretic peptide type A	Mus musculus	85-88
29544684-8	2018	We found that p40 mAb suppressed epidermal thickness and increased transepidermal water loss (TEWL) as indicator for skin barrier function with accompanying suppression of IL-23p19, IL-17A, IL-22, and keratin 16 gene expression.	Water	82-87	interleukin 12b	Mus musculus	14-17
29615322-8	2018	The low relative standard deviations from 1.6-3.1% for tap water and 2.5-5.4% for lake water was achieved.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
12095869-7	2002	This study shows that water deprivation differentially affects the expression of the ANP system, and that renal ANP expression is more important than cardiac ANP in the physiological adjustment to water deprivation.	Water	197-202	natriuretic peptide type A	Mus musculus	112-115
29729279-3	2018	Renal CAII and CAIV are involved in the reabsorption of nitrite, the autoxidation product of the signalling molecule nitric oxide (NO): 4 NO + O2 + 2 H2O   4 ONO- + 4 H+.	Water	150-153	carbonic anhydrase 2	Homo sapiens	6-10
12095869-7	2002	This study shows that water deprivation differentially affects the expression of the ANP system, and that renal ANP expression is more important than cardiac ANP in the physiological adjustment to water deprivation.	Water	197-202	natriuretic peptide type A	Mus musculus	112-115
12208541-7	2002	The physiological role of AQP2 in water transport and its expression pattern in the cochlea suggests an important role for AQP2 in fluid homeostasis of the inner ear; however, its role in the pathogenesis in Meniere"s disease remains to be established.	Water	34-39	aquaporin 2	Homo sapiens	26-30
29567160-1	2018	In this work an electrochemical procedure for Cr(VI) flow based determination in tap water is presented.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
29567160-4	2018	Under optimal conditions, the electrochemical sensor offered an excellent response to Cr(VI) and the limit of detection estimated from 3sigma was 0.5 microg L-1 (n = 3) allowing the analysis of tap water samples.	Water	198-203	nuclear RNA export factor 1	Homo sapiens	194-197
29795045-4	2018	Our structural studies show that in hCA VII the network of ordered water molecules, which connects the zinc bound solvent molecule to the proton shuttle His64, is altered compared to hCA II, causing a reduction of the catalytic efficiency.	Water	67-72	carbonic anhydrase 2	Homo sapiens	183-189
12411029-2	2002	METHODS: In the present study, the effect of IL-1beta and IL-1ra on aromatase (Arom) activity and mRNA expression in human osteoblast-like cells was investigated by [(3)H] water released upon the conversion of [1beta-(3)H] androstenedione to estrone and the reverse-transcription polymerase cain reaction (RT-PCR) method.	Water	172-177	interleukin 1 receptor antagonist	Homo sapiens	58-64
29761189-5	2018	The H2 is released by AlH3 firstly and then it reacts with NO2 and CO2 from the decomposition of RDX, leading to an increase of H2O, NO and CO.	Water	128-131	radixin	Homo sapiens	97-100
29681154-3	2018	These SAPs can self-assemble into interesting nanostructures in water upon exposure to different stimuli because beta-CD can be selectively included with different guests, such as Fc, Azo, and C11 alkyl chain, under different stimuli.	Water	64-69	aldo-keto reductase family 1 member C4	Homo sapiens	193-196
12130781-3	2002	Extrapolation to all glaciers in Alaska yields an estimated total annual volume change of -52 +/- 15 km3/year (water equivalent), equivalent to a rise in sea level (SLE) of 0.14 +/- 0.04 mm/year.	Water	111-116	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	154-157
29700546-6	2018	On the basis of the superior adsorption performance of nano-MOF materials, free residual ClO- and SCN- in water was rapidly, sensitively and selectively detected with a detection limit of 0.133 nM and 0.204 nM, respectively.	Water	106-111	sorcin	Homo sapiens	89-101
29700546-7	2018	Moreover, nano-ZIF-8 was successfully used for monitoring the concentration levels of ClO- and SCN- in specimens of tap water and Yellow River water.	Water	120-125	sorcin	Homo sapiens	86-98
29783625-1	2018	2-Methylisoborneol (2-MIB) is one of the most commonly observed taste and odor (T&amp;O) compounds present in drinking water sources.	Water	119-124	MIB E3 ubiquitin protein ligase 1	Homo sapiens	22-25
29783625-5	2018	Preservation experiments were first conducted in deionized water spiked with 2-MIB and with chlorine or permanganate at 4 and 25  C. The results indicate that 2-MIB concentrations in the water samples spiked with both chemicals remained almost constant within 14 days for all the tested conditions, suggesting that oxidation and volatilization did not cause the loss of 2-MIB in the system.	Water	187-192	MIB E3 ubiquitin protein ligase 1	Homo sapiens	161-164
29783625-5	2018	Preservation experiments were first conducted in deionized water spiked with 2-MIB and with chlorine or permanganate at 4 and 25  C. The results indicate that 2-MIB concentrations in the water samples spiked with both chemicals remained almost constant within 14 days for all the tested conditions, suggesting that oxidation and volatilization did not cause the loss of 2-MIB in the system.	Water	187-192	MIB E3 ubiquitin protein ligase 1	Homo sapiens	161-164
29748920-8	2018	Meanwhile, operating as nanoantennas, this metasurface achieves simultaneously strong local electric FE( Eloc / E0  &gt; 100) and a near-perfect absorption above 99.9% for the first time, which will benefit a wide range of applications including photocatalytic water splitting and surface-enhanced infrared absorption.	Water	261-266	elongin C	Homo sapiens	105-109
29783625-6	2018	The experiments were further conducted for three different reservoir water samples with 30-60 ng/L of indulgent 2-MIB.	Water	69-74	MIB E3 ubiquitin protein ligase 1	Homo sapiens	114-117
12130782-1	2002	Ocean measurements in the Ross Sea over the past four decades, one of the longest records near Antarctica, reveal marked decreases in shelf water salinity and the surface salinity within the Ross Gyre.	Water	140-145	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	31-34
29783625-10	2018	The results demonstrated that sodium hypochlorite can be used as an alternative preservation agent for 2-MIB in water before analysis.	Water	112-117	MIB E3 ubiquitin protein ligase 1	Homo sapiens	105-108
12083927-1	2002	Solvation of a tetrapeptide, NAc-Ser-Phe-Val-Gly-OMe (1), in water and in water/alcohol mixtures with 2,2,2-trifluoroethanol (TFE)/water or ethanol (ETH)/water has been studied by diffusion NMR and intermolecular NOE measurements.	Water	61-66	synuclein alpha	Homo sapiens	29-32
29438858-7	2018	Such MoSe2/CNF heterojunctions with a broad-spectrum-response photocatalytic performance might have potential applications in water treatment.	Water	126-131	NPHS1 adhesion molecule, nephrin	Homo sapiens	11-14
29444499-3	2018	In addition to structural and photophysical properties as well as ESIPT mechanism of all mentioned molecules, the FC and relaxed potential energy surfaces of B2 and 3R-B2 (R=CF3 and NH2) molecules were explored in gas phase and acetonitrile, cyclohexane and water solvents.	Water	258-263	immunoglobulin kappa variable 5-2	Homo sapiens	158-170
12109466-6	2002	Other biocides such as chlorothalonil, dichlofluanid, and Sea-Nine 211 were all found to be rapidly removed from the water column and be less persistent.	Water	117-122	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	58-61
29520940-2	2018	By adding water to this compound the complex [(H2 O)(tmc)Fe=O)](OTf)2 could be prepared.	Water	10-15	POU class 2 homeobox 2	Homo sapiens	64-69
29717354-8	2018	Long-term exposure to Cd and Cr through tap water consumption poses moderate carcinogenic health risks to the local residents.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
29861828-5	2018	The results from the cell model showed that pretreatment of HUVEC with the water or alkaline extracts of the polysaccharides from the huskless barley cultivars QHH and NLGL decreased the levels of reactive oxygen species (ROS), monocyte chemotactic protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) but increased the level of superoxide dismutase (SOD) and maintained cell viability.	Water	75-80	chemokine (C-C motif) ligand 2	Mus musculus	260-265
12151754-3	2002	In the kidney collecting duct, vasopressin induces the expression of aquaporin-2 (AQP2), resulting in increased water reabsorption.	Water	112-117	aquaporin 2	Rattus norvegicus	69-80
29633676-8	2018	The analysis of water samples revealed the presence of bacterial indicators of faecal contamination in the water used in the resort as well as in other areas of the municipal water network, linking the NoV gastroenteritis outbreak to tap water pollution from sewage leakage.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	234-237
12151754-3	2002	In the kidney collecting duct, vasopressin induces the expression of aquaporin-2 (AQP2), resulting in increased water reabsorption.	Water	112-117	aquaporin 2	Rattus norvegicus	82-86
29608983-7	2018	The rank order of drinking water resources based on the concentration of radon 222 was Spring &gt; Spring and Well &gt; Well &gt; Spring and Qanat &gt; Tap water.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	152-155
29605886-4	2018	The conversion of Hp1-1:Hb(III)-NO to Hp1-1:Hb(II)-NO and of Hp2-2:Hb(III)-NO to Hp2-2:Hb(II)-NO is limited by the OH-- and H2O-based catalysis.	Water	124-127	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	61-66
29605886-4	2018	The conversion of Hp1-1:Hb(III)-NO to Hp1-1:Hb(II)-NO and of Hp2-2:Hb(III)-NO to Hp2-2:Hb(II)-NO is limited by the OH-- and H2O-based catalysis.	Water	124-127	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	81-86
12121128-3	2002	EGF was conjugated to the distal end of PEG-DSPE lipid molecules in a micellar solution and the EGF-PEG-DSPE lipids were then transferred to preformed liposomes, either empty or containing the DNA-binding compound, water soluble acridine, WSA.	Water	215-220	epidermal growth factor	Homo sapiens	0-3
28566049-0	2018	Molecular dynamics simulations of apo and holo forms of fatty acid binding protein 5 and cellular retinoic acid binding protein II reveal highly mobile protein, retinoic acid ligand, and water molecules.	Water	187-192	fatty acid binding protein 5	Homo sapiens	56-130
29309870-7	2018	The potential utilization of MES technique for removal and extraction of Cd(II) and Cu(II) at low concentration levels (mgL-1) from water samples was also explored.	Water	132-137	LLGL scribble cell polarity complex component 1	Homo sapiens	120-125
12054944-10	2002	The calculated preferred nucleophilic attack of a water molecule at both the C1" and C1 atoms of representative bromonium ions conforms well to the experimentally observed product distribution.	Water	50-55	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	77-87
28903806-7	2018	Matrix-matching was used to overcome any low recovery results obtained with tap water and municipal wastewater.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
28370958-3	2018	The present study was aimed to assess the effect of replacing the habitual drinking water on the kidney function of CKDu patients residing in the North Central Province of Sri Lanka: METHODS: An interventional study was carried out to assess the disease progression rate of a CKDu population whose habitual drinking water was replaced by bottled spring water certified by Sri Lanka Standard (SLS) for a period of 18 month along with a population of CKDu patients who continued with their usual drinking water.	Water	84-89	sorcin	Homo sapiens	172-175
12021443-0	2002	Role of water in the catalytic cycle of E. coli dihydrofolate reductase.	Water	8-13	Dihydrofolate reductase	Escherichia coli	48-71
29555784-7	2018	Interestingly, AtBBX21-expressing plants had higher rates of photosynthesis, with a significant increase in photosynthetic gene expression, and higher stomatal conductance, with increased size of the stomatal opening, without any associated decline in water use efficiency.	Water	252-257	salt tolerance homolog2	Arabidopsis thaliana	15-22
28460566-0	2018	Recognition dynamics of dopamine to human Monoamine oxidase B: role of Leu171/Gln206 and conserved water molecules in the active site cavity.	Water	99-104	monoamine oxidase B	Homo sapiens	42-61
28460566-2	2018	Extensive MD simulation studies of dopamine-docked hMAO B structures have revealed the stabilization of amino-terminal of the substrate by a direct and water-mediated interaction of catalytic tyrosines, Gln206, and Leu171 residues.	Water	152-157	monoamine oxidase B	Homo sapiens	51-57
28460566-8	2018	The topology of conserved water molecular sites along with the hydration dynamics of catalytic residues, FAD, and dopamine has added a new feature on the substrate binding chemistry in hMAO B which may be useful for substrate analog inhibitor design.	Water	26-31	monoamine oxidase B	Homo sapiens	185-191
12021443-8	2002	We performed molecular dynamics simulations to determine the accessibility by water of the active site of the Michaelis complex of DHFR.	Water	78-83	Dihydrofolate reductase	Escherichia coli	131-135
29426545-7	2018	The method has been applied to the analysis of these isomers in spiked tap water with recoveries from 99.0 ~ 102.9% and relative standard deviations (RSDs) for 5 successive measurements less than 5% were also acceptable.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
12031687-3	2002	Severe polyuria was observed as an early event with no other obvious sequelae after Stx administration, in parallel with elevated urinary level of aquaporin 2 (AQP2) water channel protein that was determined by a sandwich EIA assay.	Water	166-171	aquaporin 2	Rattus norvegicus	147-158
29555284-1	2018	The effects of the addition of degassed water on bulk nanobubbles (ultrafine bubbles) of air in liquid water were investigated by measuring the volumetric concentration and size distribution at different dissolved air degree of saturation (DOS) values.	Water	40-45	CACN subunit beta associated regulatory protein	Homo sapiens	240-243
29555284-2	2018	The proportion of degassed water mixed with water containing bulk nanobubbles was increased to prepare samples having lower DOS values.	Water	27-32	CACN subunit beta associated regulatory protein	Homo sapiens	124-127
29628491-3	2018	In this study, two effective cryogenic methodologies were successfully reported to alter the physicochemical properties of a precipitate of an octyl beta-D-galactoside (Oct-Gal)-water system.	Water	178-183	galanin and GMAP prepropeptide	Homo sapiens	173-176
29712953-4	2018	Additionally, exposure to original surface water sample collected from backwater area altered the expressions of sod-2, sod-5, clk-1, and mev-1.	Water	43-48	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	113-118
29712953-4	2018	Additionally, exposure to original surface water sample collected from backwater area altered the expressions of sod-2, sod-5, clk-1, and mev-1.	Water	43-48	Superoxide dismutase [Cu-Zn]	Caenorhabditis elegans	120-125
29712953-5	2018	Moreover, mutation of sod-2 or sod-5 was susceptible to the potential toxicity of original surface water sample collected from backwater area on nematodes.	Water	99-104	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	22-27
29555284-2	2018	The proportion of degassed water mixed with water containing bulk nanobubbles was increased to prepare samples having lower DOS values.	Water	44-49	CACN subunit beta associated regulatory protein	Homo sapiens	124-127
29712953-5	2018	Moreover, mutation of sod-2 or sod-5 was susceptible to the potential toxicity of original surface water sample collected from backwater area on nematodes.	Water	99-104	Superoxide dismutase [Cu-Zn]	Caenorhabditis elegans	31-36
12031687-3	2002	Severe polyuria was observed as an early event with no other obvious sequelae after Stx administration, in parallel with elevated urinary level of aquaporin 2 (AQP2) water channel protein that was determined by a sandwich EIA assay.	Water	166-171	aquaporin 2	Rattus norvegicus	160-164
29679012-3	2018	The formation process of such concretions has been explained by diffusion and rapid syn-depositional reactions with organic solutes and other pore water constituents.	Water	147-152	synemin	Homo sapiens	84-87
11891232-1	2002	Two aquaporin (AQP)-type water channels are expressed in mammalian cornea, AQP1 in endothelial cells and AQP5 in epithelial cells.	Water	25-30	aquaporin 5	Homo sapiens	105-109
29458034-7	2018	There were good correlation between the two methods from tap water, contaminated water and river water samples were 0.9994, 0.9935 and 0.9967, respectively.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
29288883-3	2018	Electroactive, water soluble organic dye Azu-A was effectively immobilized to the host IL through simple Schiff base reaction.	Water	15-20	azurocidin 1	Homo sapiens	41-44
12054827-1	2002	The cold-shock protein CspB folds rapidly in a N &lt;= =&gt; U two-state reaction via a transition state that is about 90% native in its interactions with denaturants and water.	Water	171-176	granzyme B	Homo sapiens	23-27
29649342-0	2018	A homogeneous electrochemical sensor for Hg2+ determination in environmental water based on the T-Hg2+-T structure and exonuclease III-assisted recycling amplification.	Water	77-82	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	41-44
29649342-0	2018	A homogeneous electrochemical sensor for Hg2+ determination in environmental water based on the T-Hg2+-T structure and exonuclease III-assisted recycling amplification.	Water	77-82	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	98-101
29649342-6	2018	Under optimal conditions, the differential pulse voltammetric (DPV) response had a linear relationship with the logarithm of Hg2+ concentration in the range of 1.0 nM-0.5 muM, and the proposed method displayed great applicability for detecting Hg2+ in tap-water samples.	Water	256-261	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	125-128
29649342-6	2018	Under optimal conditions, the differential pulse voltammetric (DPV) response had a linear relationship with the logarithm of Hg2+ concentration in the range of 1.0 nM-0.5 muM, and the proposed method displayed great applicability for detecting Hg2+ in tap-water samples.	Water	256-261	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	244-247
29540552-9	2018	Indeed, mice with defects in JIP1-mediated JNK activation display enhanced memory in hippocampus-dependent tasks, such as contextual fear conditioning and Morris water maze, indicating that JIP1-JNK constrains spatial memory.	Water	162-167	mitogen-activated protein kinase 8	Mus musculus	43-46
29540552-9	2018	Indeed, mice with defects in JIP1-mediated JNK activation display enhanced memory in hippocampus-dependent tasks, such as contextual fear conditioning and Morris water maze, indicating that JIP1-JNK constrains spatial memory.	Water	162-167	mitogen-activated protein kinase 8	Mus musculus	195-198
12164272-3	2002	Treatment with the ethanol:water (1:1) extract of the rhizomes of Acorus calamus (AC-002) increased the GSH content and GST activity in the corpus striatum while insignificant changes were observed in other parameters.	Water	27-32	hematopoietic prostaglandin D synthase	Rattus norvegicus	120-123
29922130-7	2018	Additionally, TBI-induced brain water content, motor function outcome, and spatial learning and memory deficits were alleviated by IL-33 treatment.	Water	32-37	interleukin 33	Mus musculus	131-136
29519124-0	2018	Selective Membrane Complexation and Uranium Isotopes Analysis in Tap Water and Seawater Samples.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
11925162-14	2002	The nucleophilic attack by HCN or solvation by H(2)O is at least nine or six orders of magnitude slower, respectively than is nucleophilic attack by CN(-) for Pt(II), Pd(II), and Ni(II), respectively.	Water	47-52	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	27-30
29519124-1	2018	The complexation of 238U and 234U in tap water and seawater after the use of a selective membrane was examined.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
29480389-6	2018	The practical application of the probe was successfully demonstrated by analyzing Hg2+ ion and lambda-cyhalothrin in water samples.	Water	117-122	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	82-85
29683428-4	2018	By reducing the water potential and epidermal tension in planta, we rescued the adhesion defects in qua1, formally associating gaping and tensile stress patterns in the mutant.	Water	16-21	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	100-104
11897706-7	2002	Localization of a functional GHRH-R in HL and its regulation during development and aging suggest roles associated with cellular proliferation, differentiation, and/or water/electrolyte transport.	Water	168-173	growth hormone releasing hormone receptor	Rattus norvegicus	29-35
29546757-7	2018	The research provides an effective approach for uniformly depositing cost-effective a-MoS x on nanostructured photoelectrodes, for photoelectrochemical water splitting.	Water	152-157	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	86-89
29560982-5	2018	Most interestingly, the positions of the conduction band minimum (CBM) and valence band maximum (VBM) in 2D SiP2 fit perfectly the water oxidation and reduction potentials, making it a potential new 2D material that is suitable as a nanoscale photocatalyst for photo-electrochemical water splitting.	Water	131-136	gem nuclear organelle associated protein 6	Homo sapiens	108-112
29560982-5	2018	Most interestingly, the positions of the conduction band minimum (CBM) and valence band maximum (VBM) in 2D SiP2 fit perfectly the water oxidation and reduction potentials, making it a potential new 2D material that is suitable as a nanoscale photocatalyst for photo-electrochemical water splitting.	Water	283-288	gem nuclear organelle associated protein 6	Homo sapiens	108-112
29508034-0	2018	Evaluation of on-line concentration coupled to liquid chromatography tandem mass spectrometry for the quantification of neonicotinoids and fipronil in surface water and tap water.	Water	173-178	nuclear RNA export factor 1	Homo sapiens	169-172
29716294-1	2018	The geoacoustic inversion based on a horizontal towed array sonar receiving tow-ship noise has demonstrated a promising technique for the parameter inversion in shallow water.	Water	169-174	inositol polyphosphate-5-phosphatase D	Homo sapiens	80-84
11950278-3	2002	The APP + PS1 mice were impaired in water maze acquisition and retention only at the age of 11-12 months, but performed equally to controls in the T-maze task at both ages.	Water	36-41	presenilin 1	Mus musculus	10-13
29442944-1	2018	Here we present a simple yet efficient analytical method for sensing ultratrace levels of Hg2+ ions by highly water soluble CdS quantum dots functionalized with thiourea as a probe.	Water	110-115	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	90-93
29442944-5	2018	The improved detection is attributable to synthesis of less than 3 nm diameter CdS quantum dots which rendered very high water solubility and hence facilitated better interaction with Hg2+ ions.	Water	121-126	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	184-187
29442944-6	2018	The detection of Hg2+ ion was free from most interfering cations and anions, except for minor interference from Cu2+ and Pb2+ corresponding their concentrations expected in ground water.	Water	180-185	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	17-20
29480817-6	2018	In contrast, nonpersistent vaccine formulations based on dendritic cells, viral vectors, or water-soluble peptides potently synergized with checkpoint blockade of both CTLA-4 and PD-L1 and induced complete tumor regression, including in settings of primary resistance to dual checkpoint blockade.	Water	92-97	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	168-174
28918311-6	2018	Specificity arising from the 5-quinoline moiety was associated with a distinct pattern of water-mediated hydrogen bonds involving Lys235 and Glu248 in the inactive conformation favoured by ALK2.	Water	90-95	activin A receptor, type 1	Mus musculus	189-193
29228391-1	2018	We earlier reported that exposure to arsenic at concentrations in ground water of India attenuated glial fibrillary acidic protein (GFAP) during brain development.	Water	73-78	glial fibrillary acidic protein	Rattus norvegicus	99-130
11751877-2	2002	Here, we analyzed the oligomerization of the AQP3 aquaglyceroporin, which presents a mixed selectivity for water, glycerol, and urea.	Water	107-112	aquaporin 3 (Gill blood group)	Homo sapiens	45-49
29228391-1	2018	We earlier reported that exposure to arsenic at concentrations in ground water of India attenuated glial fibrillary acidic protein (GFAP) during brain development.	Water	73-78	glial fibrillary acidic protein	Rattus norvegicus	132-136
29429726-0	2018	A sonochemical synthesis of cyclodextrin functionalized Au-FeNPs for colorimetric detection of Cr6+ in different industrial waste water.	Water	130-135	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	95-98
29289846-2	2018	We previously found that Tl(III), generally considered the less stable oxidation state of thallium, is present both in the stream and in tap water distributed in the area, whereas acid mine drainages only contain Tl(I).	Water	141-146	nuclear RNA export factor 1	Homo sapiens	137-140
11866609-1	2002	A detailed investigation of the hydration structure of Zn2+, Ni2+, and Co2+ in water solutions has been carried out combining X-ray absorption fine structure (EXAFS) spectroscopy and Molecular Dynamics (MD) simulations.	Water	79-84	complement C2	Homo sapiens	71-74
29537275-7	2018	The performance of p-NiFe2O4/n-Fe2O3 composites in PEC water oxidation was further enhanced by their deposition over 3D-NSP substrate.	Water	55-60	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	120-123
29460246-9	2018	In addition, MoS2 nanosheets/DNA/silicon dot nanoassembly fluorescent Hg sensor efficiently detected the presence of Hg2+ ions in real-time water samples, which was comparably detected by the conventional atomic absorbance spectrometer (AAS).	Water	140-145	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	117-120
11866610-5	2002	This procedure has been successfully applied to the Co2+-H2O open-shell system and, for the first time, Co-oxygen and Co-hydrogen pair potential functions have been determined and employed in MD simulations.	Water	57-60	complement C2	Homo sapiens	52-55
11887874-3	2002	Resulting organic carbon/water partition coefficients (log Koc) were related to suspended sediment concentration and ranged from 2.28 to 5.20 for diuron; and from 2.41 to 4.89 for Irgarol 1051.	Water	25-30	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	59-62
29305611-1	2018	Elastin is a peculiar elastomer in that it requires water to maintain resilience, and its mechanical properties are closely associated with the immediate aqueous environment.	Water	52-57	elastin	Homo sapiens	0-7
29305611-2	2018	The bulk, extra- and intrafibrillar water plays important roles in both elastic and viscoelastic properties of elastin.	Water	36-41	elastin	Homo sapiens	111-118
29350629-2	2018	The nAg were synthesized, dispersed in deionized (DI) water and casted onto a pure PPS film, resulting in a conductive film upon the evaporation of DI water and thermal post-annealing.	Water	54-59	NBAS subunit of NRZ tethering complex	Homo sapiens	4-7
11867710-2	2002	The effect of sequence variation on alpha-helix formation for alanine-rich peptides, Ac-Ala21-methyl amide (A21) and Ac-A5 (AAARA)3A-methyl amide (Fs peptide), is investigated by atomic simulation studies of the thermodynamics of the helix-coil transition in explicit water.	Water	268-273	small nucleolar RNA, H/ACA box 5A	Homo sapiens	117-122
29160692-3	2018	The aim was to examine treatment with in vitro generated proinflammatory protein S100A9 aggregate species alone or with glutamate antibodies (Glu-Abs) on Morris water maze (MWM) spatial learning and memory performance in 12 month old mice.	Water	161-166	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	81-87
29305611-9	2018	Elastin treated with 45% PEG shows a very rigid behavior as most of the extrafibrillar water is eliminated.	Water	87-92	elastin	Homo sapiens	0-7
29305611-10	2018	These results suggest that extrafibrillar water is crucial for elastin to maintain its elastic behavior.	Water	42-47	elastin	Homo sapiens	63-70
11926132-1	2002	Uroguanylin, guanylin, lymphoguanylin and bacterial enterotoxin ST are structurally related peptides that activate common guanylate cyclase signaling molecules and, via cyclic GMP (cGMP), regulate water and ion homeostasis in a variety of tissues and organs, including the gastrointestinal (GI) tract, kidneys, lung, prostate, etc.	Water	197-202	guanylate cyclase activator 2A	Homo sapiens	3-11
29305611-12	2018	An increase in stress relaxation was observed for elastin treated with 30% PEG, indicating a more viscous behavior of elastin when the amount of extrafibrillar water is significantly reduced.	Water	160-165	elastin	Homo sapiens	50-57
29305611-12	2018	An increase in stress relaxation was observed for elastin treated with 30% PEG, indicating a more viscous behavior of elastin when the amount of extrafibrillar water is significantly reduced.	Water	160-165	elastin	Homo sapiens	118-125
29305611-13	2018	Results from this study shed light on the close association between the bulk, extra- and intrafibrillar water pools and the mechanics of elastin.	Water	104-109	elastin	Homo sapiens	137-144
29132004-8	2018	Negative perceptions of tap water were associated with lower odds of consuming tap water (ORPCAcomponent1=0.73, 95% CI 0.56-0.94; ORPCAcomponent2=0.67, 95% CI 0.49-0.93); women had higher odds of drinking purchased water compared to men (OR=1.90, 95% CI 1.11-3.26).	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
29132004-8	2018	Negative perceptions of tap water were associated with lower odds of consuming tap water (ORPCAcomponent1=0.73, 95% CI 0.56-0.94; ORPCAcomponent2=0.67, 95% CI 0.49-0.93); women had higher odds of drinking purchased water compared to men (OR=1.90, 95% CI 1.11-3.26).	Water	28-33	nuclear RNA export factor 1	Homo sapiens	79-82
29132004-8	2018	Negative perceptions of tap water were associated with lower odds of consuming tap water (ORPCAcomponent1=0.73, 95% CI 0.56-0.94; ORPCAcomponent2=0.67, 95% CI 0.49-0.93); women had higher odds of drinking purchased water compared to men (OR=1.90, 95% CI 1.11-3.26).	Water	83-88	nuclear RNA export factor 1	Homo sapiens	24-27
29132004-8	2018	Negative perceptions of tap water were associated with lower odds of consuming tap water (ORPCAcomponent1=0.73, 95% CI 0.56-0.94; ORPCAcomponent2=0.67, 95% CI 0.49-0.93); women had higher odds of drinking purchased water compared to men (OR=1.90, 95% CI 1.11-3.26).	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
29132004-8	2018	Negative perceptions of tap water were associated with lower odds of consuming tap water (ORPCAcomponent1=0.73, 95% CI 0.56-0.94; ORPCAcomponent2=0.67, 95% CI 0.49-0.93); women had higher odds of drinking purchased water compared to men (OR=1.90, 95% CI 1.11-3.26).	Water	83-88	nuclear RNA export factor 1	Homo sapiens	24-27
29132004-8	2018	Negative perceptions of tap water were associated with lower odds of consuming tap water (ORPCAcomponent1=0.73, 95% CI 0.56-0.94; ORPCAcomponent2=0.67, 95% CI 0.49-0.93); women had higher odds of drinking purchased water compared to men (OR=1.90, 95% CI 1.11-3.26).	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
28930449-1	2018	Catalytic four-electron reduction of O2 to water is one of the most extensively studied electrochemical reactions due to O2 exceptional availability and high O2/H2O redox potential, which may in particular allow highly energetic reactions in fuel cells.	Water	43-48	immunoglobulin kappa variable 1D-39	Homo sapiens	158-164
29869011-1	2018	Aquaporin-4 (AQP4) is a selective water channel, which expresses on the plasma membrane of myofibers and regulates the osmotic pressure, energy metabolism and morphological changes in myofibers by modulating water transport across sarcolemma in skeletal muscles.	Water	34-39	aquaporin 4	Homo sapiens	0-11
29869011-1	2018	Aquaporin-4 (AQP4) is a selective water channel, which expresses on the plasma membrane of myofibers and regulates the osmotic pressure, energy metabolism and morphological changes in myofibers by modulating water transport across sarcolemma in skeletal muscles.	Water	34-39	aquaporin 4	Homo sapiens	13-17
29869011-1	2018	Aquaporin-4 (AQP4) is a selective water channel, which expresses on the plasma membrane of myofibers and regulates the osmotic pressure, energy metabolism and morphological changes in myofibers by modulating water transport across sarcolemma in skeletal muscles.	Water	208-213	aquaporin 4	Homo sapiens	0-11
29869011-1	2018	Aquaporin-4 (AQP4) is a selective water channel, which expresses on the plasma membrane of myofibers and regulates the osmotic pressure, energy metabolism and morphological changes in myofibers by modulating water transport across sarcolemma in skeletal muscles.	Water	208-213	aquaporin 4	Homo sapiens	13-17
29428972-4	2018	This links bulk (convective) flow of CSF into brain along the outside of penetrating arteries, glia-mediated convective transport of fluid and solutes through the brain extracellular space (ECS) involving the aquaporin-4 (AQP4) water channel, and finally delivery of fluid to venules for clearance along peri-venous spaces.	Water	228-233	aquaporin 4	Homo sapiens	209-220
11926132-2	2002	Any disruptions in water and ionic homeostasis due to reduced production of one or more of the guanylin family of peptides can potentially lead to carcinogenic and inflammatory stimuli.	Water	19-24	guanylate cyclase activator 2A	Homo sapiens	95-103
29428972-4	2018	This links bulk (convective) flow of CSF into brain along the outside of penetrating arteries, glia-mediated convective transport of fluid and solutes through the brain extracellular space (ECS) involving the aquaporin-4 (AQP4) water channel, and finally delivery of fluid to venules for clearance along peri-venous spaces.	Water	228-233	aquaporin 4	Homo sapiens	222-226
12221525-9	2002	This finding suggests that manipulations of the CFTR Cl channel could affect transepithelial Cl transport rates and water movement into the tear film.	Water	116-121	cystic fibrosis transmembrane conductance regulator	Oryctolagus cuniculus	48-52
29380891-2	2018	Stable dispersions of hydrophilic hGO sheets in water ( 100 mg mL-1 ) can be readily achieved.	Water	48-53	homogentisate 1,2-dioxygenase	Homo sapiens	34-37
29428877-2	2018	Because of postmortem studies have provided evidences for oxidative damage and alteration of water flow and energy metabolism, we carried out an investigation about AQP4 and 9, demonstrated in the brain to maintain water and energy homeostasis.	Water	215-220	aquaporin 4	Homo sapiens	165-169
11832768-0	2002	The aquaporin-2 water channel in autosomal dominant primary nocturnal enuresis.	Water	16-21	aquaporin 2	Homo sapiens	4-15
29618130-0	2018	131I DOSE ESTIMATION FROM INTAKE OF TAP WATER IN THE EARLY PHASE AFTER FUKUSHIMA DAIICHI NUCLEAR POWER PLANT ACCIDENT.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
29618130-2	2018	To study its effect, we estimated the internal exposure due to intake of tap water in the early phase after the accident.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
29043393-7	2018	Food ingestion is diminished by knockdown of DH44, but not LK, and water retention is increased by LK knockdown only.	Water	67-72	Leucokinin	Drosophila melanogaster	99-101
29154205-3	2018	The source of tap water for Minami-Soma City is groundwater, which is treated by rapid filtration before distribution in two of the three treatment plants.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
29154205-8	2018	In tap water and groundwater, radiocesium was decreased to below the detection limit in 2016 except for four stations.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
29618130-3	2018	As the number of measured values of tap water following the accident was limited, 131I concentration in tap water was estimated by 1-compartment model using the deposition amount of radionuclides calculated by an atmospheric transport, dispersion and deposition simulation.	Water	108-113	nuclear RNA export factor 1	Homo sapiens	104-107
11832768-2	2002	Recently, linkage analysis revealed a 2-point lod score of 4.2 in 6 families with dominant primary nocturnal enuresis around the aquaporin-2 (AQP2) water channel locus.	Water	148-153	aquaporin 2	Homo sapiens	129-140
11832768-2	2002	Recently, linkage analysis revealed a 2-point lod score of 4.2 in 6 families with dominant primary nocturnal enuresis around the aquaporin-2 (AQP2) water channel locus.	Water	148-153	aquaporin 2	Homo sapiens	142-146
11852078-5	2002	These results show that residues around the NPA1 box can influence the folding of the MIP in the membrane, and provide structural evidence for the poor water transport properties of MIP, as the NPA boxes lie outside the plane of the membrane.	Water	152-157	major intrinsic protein of lens fiber	Rattus norvegicus	182-185
29334177-3	2018	The fabricated PP@PIL fabrics exhibit impressive switchable oil/water separation (eta&gt;99 %) and dye absorption performance (q=410 mg g-1 ), as well as high antibacterial properties.	Water	64-69	serpin family A member 2 (gene/pseudogene)	Homo sapiens	18-21
29334177-4	2018	The oil/water separation can be easily switched by anion exchanging of the PIL segments.	Water	8-13	serpin family A member 2 (gene/pseudogene)	Homo sapiens	75-78
29175684-0	2018	Removal of pharmaceutical compounds in water and wastewater using fungal oxidoreductase enzymes.	Water	39-44	thioredoxin reductase 1	Homo sapiens	73-87
29175684-3	2018	Biological transformation of these contaminants using white-rot fungi (WRF) and their oxidoreductase enzymes has been proposed as a low cost and environmentally friendly solution for water treatment.	Water	183-188	thioredoxin reductase 1	Homo sapiens	86-100
29175684-6	2018	This review summarizes and analyzes the studies performed on PhACs removal from spiked pure water and real wastewaters using oxidoreductase enzymes and the data related to degradation efficiencies of the most studied compounds.	Water	92-97	thioredoxin reductase 1	Homo sapiens	125-139
11814407-8	2002	For all animals combined (Tg+ and Tg-), as well as for aged 19M animals alone, hippocampal SYN-IR was correlated with impaired acquisition and spatial reference memory in the Morris water maze task, suggestive that elevated hippocampal SYN-IR is a manifestation of pathophysiologic synaptic processing within the hippocampus.	Water	182-187	synaptophysin	Mus musculus	91-94
29548396-4	2018	Although COD and TOC in permeate water increased continuously due to the transfer of volatile components from wastewater, organic rejection of over 95% was achieved in wastewater.	Water	33-38	rhomboid 5 homolog 2	Homo sapiens	17-20
29497453-0	2018	Gene and protein expression of CXCR4 in adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis undergoing thermal water nasal inhalations.	Water	134-139	C-X-C motif chemokine receptor 4	Homo sapiens	31-36
29253750-1	2018	A novel water-compatible surface molecularly imprinted thiol-functionalized titanium dioxide (TiO2) material (CMIP-coated TiO2) was prepared in water, using 2, 4-dinitrophenol (2, 4-DNP) as template molecule and o-phenylenediamine (OPDA) as both functional monomer and cross-linker.	Water	8-13	c-Maf inducing protein	Homo sapiens	110-114
29253750-1	2018	A novel water-compatible surface molecularly imprinted thiol-functionalized titanium dioxide (TiO2) material (CMIP-coated TiO2) was prepared in water, using 2, 4-dinitrophenol (2, 4-DNP) as template molecule and o-phenylenediamine (OPDA) as both functional monomer and cross-linker.	Water	144-149	c-Maf inducing protein	Homo sapiens	110-114
29540771-5	2018	According to the models, the optimal process parameters which maximize cold-water-insoluble nitrogen and minimize hot-water-insoluble nitrogen for the synthesis of urea formaldehyde were as follows urea: formaldehyde molar ratio was 1.33, reaction temperature was 43.5  C, and reaction time was 1.64 h. Under these conditions, the content of cold-water-insoluble nitrogen was 22.14%, and hot-water-insoluble nitrogen was 9.87%.	Water	118-123	alcohol dehydrogenase iron containing 1	Homo sapiens	114-117
29540771-5	2018	According to the models, the optimal process parameters which maximize cold-water-insoluble nitrogen and minimize hot-water-insoluble nitrogen for the synthesis of urea formaldehyde were as follows urea: formaldehyde molar ratio was 1.33, reaction temperature was 43.5  C, and reaction time was 1.64 h. Under these conditions, the content of cold-water-insoluble nitrogen was 22.14%, and hot-water-insoluble nitrogen was 9.87%.	Water	118-123	alcohol dehydrogenase iron containing 1	Homo sapiens	114-117
29540771-5	2018	According to the models, the optimal process parameters which maximize cold-water-insoluble nitrogen and minimize hot-water-insoluble nitrogen for the synthesis of urea formaldehyde were as follows urea: formaldehyde molar ratio was 1.33, reaction temperature was 43.5  C, and reaction time was 1.64 h. Under these conditions, the content of cold-water-insoluble nitrogen was 22.14%, and hot-water-insoluble nitrogen was 9.87%.	Water	118-123	alcohol dehydrogenase iron containing 1	Homo sapiens	114-117
29369621-9	2018	Tap water samples from residential area were tested using this sensor which showed good agreement with standard colorimetric measurement methods.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
11790533-3	2002	Furthermore, the specific interaction of each TCR with its cognate pMHC partner is quite variable and also involves bound water molecules at the TCR/pMHC interface.	Water	122-127	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	46-49
29463835-0	2018	Strontium isotope ratios of human hair record intra-city variations in tap water source.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
11790533-3	2002	Furthermore, the specific interaction of each TCR with its cognate pMHC partner is quite variable and also involves bound water molecules at the TCR/pMHC interface.	Water	122-127	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	145-148
29405712-4	2018	We reproduced the experimental results by calculating the period of oscillatory motion by considering the experimental values of physicochemical parameters describing the time evolution of camphor concentration profile and the friction acting on a boat, such as diffusion and dissolution rates of camphor, viscosity of the water phase, and the threshold concentration of camphor necessary to accelerate the boat from the resting state.	Water	323-328	ataxin 1 like	Homo sapiens	248-252
11911489-1	2002	Both simultaneous and sequential exposure to arsenite and benzo[a]pyrene (BaP) potentially occur in human populations drinking arsenic-contaminated water or burning arsenic-contaminated coal.	Water	148-153	prohibitin 2	Homo sapiens	74-77
29400958-1	2018	Nature routinely engages alcohols as leaving groups, as DNA biosynthesis relies on the removal of water from ribonucleoside diphosphates by a radical-mediated "spin-center shift" (SCS) mechanism.	Water	98-103	spindlin 1	Homo sapiens	160-164
29277735-7	2018	Six stacks of SiO2/Al2O with a total thickness of approximately 35 nm efficiently prevented oxygen and water molecules from interacting with the CNF film.	Water	103-108	NPHS1 adhesion molecule, nephrin	Homo sapiens	145-148
11822467-0	2002	Fluorescence sensing of ionic analytes in water: from transition metal ions to vitamin B13.	Water	42-47	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	87-90
29266943-4	2018	In this study, X-ray crystallography showed acesulfame potassium (Ace K) binding directly to the catalytic zinc in CA IX (mimic) and through a bridging water in CA II.	Water	152-157	carbonic anhydrase 2	Homo sapiens	161-166
29191396-1	2018	INTRODUCTION: This study"s purpose is to determine whether nonconsumption of tap water is associated with lower prevalence of elevated blood lead levels and higher prevalence of dental caries in children and adolescents.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
29384260-3	2018	Herein, using the reversible n-type doping/de-doping reaction of the solid-state polytriphenylamine-based battery electrode, we decouple the H2 and O2 production in acid water electrolysis.	Water	170-175	relaxin 2	Homo sapiens	141-150
29429876-3	2018	We present room temperature neutron structures of hCA II in complex with three clinical drugs that provide in-depth analysis of drug binding, including protonation states of the inhibitors, hydration water structure, and direct visualization of hydrogen-bonding networks in the enzyme"s active site.	Water	200-205	carbonic anhydrase 2	Homo sapiens	50-56
29191396-7	2018	Children and adolescents who did not drink water were less likely than tap water drinkers to have an elevated blood lead level (adjusted prevalence ratios=0.62, 95% confidence limits=0.42, 0.90).	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
12082253-6	2002	IGF BP1 was negatively correlated with blood viscosity eta (high shear rate r=-0.516, p=0.024) and positively correlated with the percentage of extracellular water in total body water (ECW/TBW) (r=0.488, p=0.039).	Water	158-163	insulin like growth factor binding protein 1	Homo sapiens	0-7
29104107-9	2018	Findings suggest that (1) tap water treated by RO is equally preferable to some bottled water, (2) personality traits may affect water preferences, and (3) prior findings of gender differences in preferences for bottled water may reflect personality characteristics.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
29436232-2	2018	Here, we aimed to clarify the function of transporters at the BAB in regulating CSF clearance of water-soluble organic anion drugs based on quantitative targeted absolute proteomics (QTAP) and in vivo analyses.	Water	97-102	colony stimulating factor 2	Rattus norvegicus	80-83
29146458-5	2018	Convenience was the only contextual predictor - the inconvenience of transporting bottled water has a negative effect on its consumption, and a positive effect on tap water consumption.	Water	167-172	nuclear RNA export factor 1	Homo sapiens	163-166
29248456-6	2018	Further, macroglial Muller cells, which influence the integrity of the BRB and prevent retinal edema, became gliotic and expressed increased levels of water (aquaporin-4) and ion (Kir4.1) channels.	Water	151-156	aquaporin 4	Mus musculus	158-169
12082253-6	2002	IGF BP1 was negatively correlated with blood viscosity eta (high shear rate r=-0.516, p=0.024) and positively correlated with the percentage of extracellular water in total body water (ECW/TBW) (r=0.488, p=0.039).	Water	178-183	insulin like growth factor binding protein 1	Homo sapiens	0-7
29101887-2	2018	Results indicated that fluoride content in drinking water ranged from0.27 to 10.3mgL-1 (average 1.70mgL-1).	Water	52-57	LLGL scribble cell polarity complex component 1	Homo sapiens	81-86
11745145-0	2001	Lipase-catalyzed synthesis of geranyl acetate in n-hexane with membrane-mediated water removal.	Water	81-86	PAN0_003d1715	Moesziomyces antarcticus	0-6
29101220-3	2018	The recently proposed "glymphatic" (glial-lymphatic) hypothesis posits that solute clearance is convective and driven by active fluid transport from para-arterial to paravenous spaces though aquaporin-4 water channels in astrocyte endfeet.	Water	203-208	aquaporin 4	Homo sapiens	191-202
29069074-4	2018	Changes in water signal correlated well with changes in cerebral water content (R=0.74) and AQP4 expression (R=0.97) in the piglet brain.ConclusionThe data show that NIRS can detect cerebral edema early in the injury process, thus providing an opportunity to initiate therapy at an earlier and more effective time-point after an insult than is available with current technology.	Water	11-16	aquaporin 4	Homo sapiens	92-96
29291441-1	2018	A new water-soluble conjugate, consisting of a chlorin-based photosensitizing part, and a 4-arylaminoquinazoline moiety with high potential affinity to an epidermal growth factor receptors (EGFR) and vascular endothelial growth factor receptors (VEGFR), suitable for photodynamic therapy (PDT), was synthesized starting from methylpheophorbide-a in seven steps.	Water	6-11	kinase insert domain receptor	Homo sapiens	200-244
29291441-1	2018	A new water-soluble conjugate, consisting of a chlorin-based photosensitizing part, and a 4-arylaminoquinazoline moiety with high potential affinity to an epidermal growth factor receptors (EGFR) and vascular endothelial growth factor receptors (VEGFR), suitable for photodynamic therapy (PDT), was synthesized starting from methylpheophorbide-a in seven steps.	Water	6-11	kinase insert domain receptor	Homo sapiens	246-251
29227091-2	2018	In this study, we surprisingly found that, under vacuum-UV (VUV) excitation, a gaseous mixture of CH2Cl2/H2O/analyte (OVOCs) in N2 buffer generated large amounts of H3O+ and protonated analyte even when the photon energy was lower than the ionization energy of the neutral species involved.	Water	105-108	H3 clustered histone 15	Homo sapiens	165-168
29338044-6	2018	Using knock-in mouse models previously generated in our laboratory, in the present work, we identified genes that exhibited altered abundance in the mutant lenses, including decreased transcripts for Clic5, an intracellular water channel in Cryaa-R49C heterozygous mutant lenses, and increased transcripts for Eno1b in Cryab-R120G heterozygous mutant lenses.	Water	224-229	crystallin, alpha A	Mus musculus	241-246
29387036-4	2017	Aquaporin-4 channels are the chief transporters of water through these compartments.	Water	51-56	aquaporin 4	Homo sapiens	0-11
28806668-0	2018	Combination of electrochemical biosensor and textile threads: A microfluidic device for phenol determination in tap water.	Water	116-121	nuclear RNA export factor 1	Homo sapiens	112-115
28906027-0	2018	SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling.	Water	71-76	aquaporin 4	Mus musculus	15-19
28906027-5	2018	Here, using co-immunoprecipitation and Forster resonance energy transfer, we report that AQP4 physically co-assembles with the sulfonylurea receptor 1-transient receptor potential melastatin 4 (SUR1-TRPM4) monovalent cation channel to form a novel heteromultimeric water/ion channel complex.	Water	265-270	aquaporin 4	Mus musculus	89-93
28906027-8	2018	Together, these findings demonstrate a novel molecular mechanism involving the SUR1-TRPM4-AQP4 complex to account for bulk water influx during astrocyte swelling.	Water	123-128	aquaporin 4	Mus musculus	90-94
29285589-8	2018	Therefore, the sensor can be used as an efficient and reusable fluorescent sensor for recognition of Hg2+ in water.	Water	109-114	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	101-104
28986111-5	2018	In subsurface (&gt;5m) water, the DO level varied from 0.71 to 6.65mgL-1 and from 6.58 to 8.20mgL-1 in the summer and winter periods, respectively.	Water	23-28	LLGL scribble cell polarity complex component 1	Homo sapiens	67-72
29171691-3	2018	The presence of Na cations is highly beneficial for exfoliating defect-free and few-layer MX2 nanosheets in water in the presence of small-sized micelles of polymeric surfactant, and significantly elevates the exfoliation yield by more than one order of magnitude compared to a conventional surfactant-assisted exfoliation.	Water	108-113	MX dynamin like GTPase 2	Homo sapiens	90-93
29098803-3	2017	Over CoCl2  6 H2 O, a high carbon yield of C13 oxygenates (about 75 %) can be achieved under mild conditions (353 K, 20 h).	Water	14-18	homeobox C13	Homo sapiens	43-46
33525852-2	2017	Both factors are equally to blame: a leaking bathtub may have plenty of water if the tap is left open; if not, it will soon be empty.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	85-88
28649022-8	2017	Furthermore, the gadget was applied for Hg2+ detection in tap water sample.	Water	62-67	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	40-43
29050579-5	2017	It was found that the C10, C12 and C14 derivatives formed stable oil-in-water emulsions and the emulsion droplet size decreased with increasing alkyl chain length.	Water	72-77	chromosome 12 open reading frame 57	Homo sapiens	22-25
29165475-0	2017	Effect of the water fraction isolated from Fructus Ligustri Lucidi extract on bone metabolism via antagonizing a calcium-sensing receptor in experimental type 1 diabetic rats.	Water	14-19	calcium-sensing receptor	Rattus norvegicus	113-137
29165475-2	2017	This study was designed to elucidate the action of water fraction isolated from the FLL extract on bone metabolism and a calcium-sensing receptor (CaSR) in parathyroid glands and kidneys of diabetic rats.	Water	51-56	calcium-sensing receptor	Rattus norvegicus	121-145
29165475-2	2017	This study was designed to elucidate the action of water fraction isolated from the FLL extract on bone metabolism and a calcium-sensing receptor (CaSR) in parathyroid glands and kidneys of diabetic rats.	Water	51-56	calcium-sensing receptor	Rattus norvegicus	147-151
29165475-6	2017	This study reveals that the water fraction may be an active component of the FLL extract that exerts beneficial effects on improving bone metabolism via regulating vitamin D metabolism in kidney and vitamin D-dependent calcium transporters in duodenum as well as modulating the expression of CaSR in the parathyroid gland and kidneys.	Water	28-33	calcium-sensing receptor	Rattus norvegicus	292-296
29259558-12	2017	RNA sequencing of MDCK cells showed that a 50 cm H2O pressure load upregulated keratin 14, an intermediate filament, 12-fold.	Water	49-52	keratin 14	Canis lupus familiaris	79-89
29199977-2	2017	Hydrolysis of GTP in water is accelerated by coordination to K-Ras, where GTP adopts a high-energy conformation approaching the transition state.	Water	21-26	KRAS proto-oncogene, GTPase	Homo sapiens	61-66
28551776-1	2017	Aquaporin-4 (AQP4) is the predominant water channel in the brain and is expressed in high density in astrocytes.	Water	38-43	aquaporin 4	Mus musculus	0-11
28551776-1	2017	Aquaporin-4 (AQP4) is the predominant water channel in the brain and is expressed in high density in astrocytes.	Water	38-43	aquaporin 4	Mus musculus	13-17
28551776-2	2017	By fluxing water along osmotic gradients, AQP4 contributes to brain volume and ion homeostasis.	Water	11-16	aquaporin 4	Mus musculus	42-46
29232000-3	2018	The resolution efficiency was up to 88.4%, when the ratio of rac-1 and 2 was 1:0.8 in THF with little water (10:1 v/v).	Water	102-107	Rac family small GTPase 1	Homo sapiens	61-72
29790028-1	2018	Blood concentration of glucagon-like peptide-1 (GLP-1) increased 5 min after per os administration of water, sodium chloride solution, or glucose solution.	Water	102-107	glucagon	Rattus norvegicus	23-46
29790028-1	2018	Blood concentration of glucagon-like peptide-1 (GLP-1) increased 5 min after per os administration of water, sodium chloride solution, or glucose solution.	Water	102-107	glucagon	Rattus norvegicus	48-53
29528025-0	2018	Natural Thermal Spa Water Versus Hyperthermic Tap Water for Treatment of Recalcitrant Hand Warts in Organ Transplant Recipients: A Patient-Blinded, Comparative Preliminary Study.	Water	20-25	surfactant protein A2	Homo sapiens	16-19
29433210-4	2018	ICA applied to MIR spectra gave Independent Components (ICs) that were attributed to the molecular characteristics of protein, water and fat.	Water	127-132	membrane associated ring-CH-type finger 8	Homo sapiens	15-18
29064483-2	2018	Water scarcity and desalination treatment provide the general population of countries from these regions (e.g., Kuwait and Cyprus) with unique tap water characteristics.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	143-146
29064483-8	2018	Median tap water TTHM in Kuwait (6.7 (5.4, 11.6) mug/l) did not correlate with urinary or air THM and they were lower than those in Cyprus (29.5 (20.1, 48.0) mug/l; P&lt;0.01).	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
28283882-3	2018	Importantly, water transport at BBB is regulated by water channels, aquaporins (AQPs), with AQP4 being expressed in astrocytic end-feet surrounding brain endothelium.	Water	13-18	aquaporin 4	Mus musculus	92-96
29126642-1	2018	Antibiotic-resistant bacteria (ARB) are a potential threat to human health through drinking water with strong evidence of ARB presence in post treated tap water around the world.	Water	92-97	nuclear RNA export factor 1	Homo sapiens	151-154
29126642-1	2018	Antibiotic-resistant bacteria (ARB) are a potential threat to human health through drinking water with strong evidence of ARB presence in post treated tap water around the world.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	151-154
29126642-4	2018	A literature search was carried out to collate data on the effect of environmental conditions on AR E. coli, the effect of different water treatments on AR E. coli and typical human consumption levels of tap water.	Water	208-213	nuclear RNA export factor 1	Homo sapiens	204-207
29126642-6	2018	Overall results show the mean adult human exposure to AR E. coli from tap water consumption ranged between 3.44x10-7 and 2.95x10-1cfu/day for the scenarios tested and varied depending on the water treatments used.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
29127799-0	2018	Persistence of antibiotic resistance genes and bacterial community changes in drinking water treatment system: From drinking water source to tap water.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	141-144
29127799-6	2018	The total abundance of the detected ARGs in tap water was much lower than that in source water.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
29127799-9	2018	Bacteria and ARGs were still present in tap water after treatment, though they were significantly reduced.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
29054010-4	2018	It is controlled by changing the water temperature in the washing bottle through which the Ar/H2 (80:20) gas flows.	Water	33-38	ADP-ribosylhydrolase like 1	Homo sapiens	91-96
29338222-1	2018	DFT calculations for CH3+ within a constrained cage of water molecules permit the controlled manipulation of distances rax and req to "axial" and "equatorial" waters.	Water	55-60	retina and anterior neural fold homeobox	Homo sapiens	119-122
29118028-0	2018	Dynamic functional contribution of the water channel AQP5 to the water permeability of peripheral lens fiber cells.	Water	39-44	aquaporin 5	Rattus norvegicus	53-57
29118028-0	2018	Dynamic functional contribution of the water channel AQP5 to the water permeability of peripheral lens fiber cells.	Water	65-70	aquaporin 5	Rattus norvegicus	53-57
29118028-8	2018	Our results show that AQP5 forms functional water channels in the rodent lens, and they suggest that dynamic membrane insertion of AQP5 may regulate water fluxes in the lens by modulating PH2O in the outer cortex.	Water	44-49	aquaporin 5	Rattus norvegicus	22-26
29118028-8	2018	Our results show that AQP5 forms functional water channels in the rodent lens, and they suggest that dynamic membrane insertion of AQP5 may regulate water fluxes in the lens by modulating PH2O in the outer cortex.	Water	149-154	aquaporin 5	Rattus norvegicus	131-135
28512710-1	2018	Two prominent polybrominated diphenyl ether (PBDE) congeners have been included in the persistent organic pollutant list, 2,2",4,4",5-tetrabromodiphenyl ether (BDE-99) and 2,2,4,4"-tetrabromodiphenyl ether (BDE-47), which have been detected in treated municipal wastewater, river water, and sediments in China.	Water	267-272	homeobox D13	Homo sapiens	46-49
28512710-1	2018	Two prominent polybrominated diphenyl ether (PBDE) congeners have been included in the persistent organic pollutant list, 2,2",4,4",5-tetrabromodiphenyl ether (BDE-99) and 2,2,4,4"-tetrabromodiphenyl ether (BDE-47), which have been detected in treated municipal wastewater, river water, and sediments in China.	Water	267-272	homeobox D13	Homo sapiens	160-163
29169099-2	2018	Studies on exposure to arsenic (As) in tap water and the risk of GDM have not provided conclusive evidence, particularly when levels of exposure were low (from 10 to 50microg As/L).	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
29055082-1	2018	Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system (CNS) caused by autoantibodies (NMO-IgG) against the water channel aquaporin-4 (AQP4).	Water	149-154	aquaporin 4	Homo sapiens	163-174
29055082-1	2018	Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system (CNS) caused by autoantibodies (NMO-IgG) against the water channel aquaporin-4 (AQP4).	Water	149-154	aquaporin 4	Homo sapiens	176-180
29068523-7	2018	Finally, the proposed probe was used to detect Hg2+ in real water samples, and its result was satisfactory.	Water	60-65	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	47-50
29136518-4	2018	Several independent lines of evidence obtained from microcosm experiments with the methanotrophic enrichment culture, tap water and bentazone at concentrations below 2 mg/L showed methanotrophic co-metabolic bentazone transformation: The culture removed 53% of the bentazone in 21 days in presence of 5 mg/L of methane, while only 31% was removed in absence of methane.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
29199752-1	2018	The beta6.3-helical channel of the marine cytotoxic peptide, polytheonamide B (pTB), is examined in water, the POPC bilayer, and a 1 : 1 chloroform/methanol mixture using all-atom molecular dynamics simulations.	Water	100-105	polypyrimidine tract binding protein 1	Homo sapiens	61-77
29199752-1	2018	The beta6.3-helical channel of the marine cytotoxic peptide, polytheonamide B (pTB), is examined in water, the POPC bilayer, and a 1 : 1 chloroform/methanol mixture using all-atom molecular dynamics simulations.	Water	100-105	polypyrimidine tract binding protein 1	Homo sapiens	79-82
29199752-7	2018	It is suggested that the collective behavior of water molecules inside the pore in the membrane is crucial for the permeation of ions through the pTB channel.	Water	48-53	polypyrimidine tract binding protein 1	Homo sapiens	146-149
29623145-1	2018	We constructed a water-soluble lipopolymer (WSLP) as a nonviral gene carrier to deliver siRNA targeting NR2B.	Water	17-22	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	104-108
29375520-7	2017	These results suggest that AQP4 plays a role in the pathogenesis of ETEC-induced diarrhea by mediating water transport.	Water	103-108	aquaporin 4	Mus musculus	27-31
30956946-2	2018	The physical problem considered is the one of the simulation of the hydrodynamic flow past the hull of a ship advancing in calm water.	Water	128-133	inositol polyphosphate-5-phosphatase D	Homo sapiens	105-109
11705768-3	2001	As we recently demonstrated, amylin also stimulates water intake most likely via its excitatory action on subfornical organ (SFO) neurons.	Water	52-57	islet amyloid polypeptide	Rattus norvegicus	29-35
11764906-2	2001	Water blast with fatal outcome almost exclusively occurs in wars at sea.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	68-71
29468888-4	2018	We used the double emulsion method (water/oil/water) to prepare 5FU-encapsulated Fe3O4 magnetic nanoparticles modified with PCL-PEG-PCL copolymer.	Water	46-51	PHD finger protein 1	Homo sapiens	124-127
11748259-5	2001	In the presence of the substrates hydrogen peroxide (H(2)O(2)) and NO(2)(-), cell and vessel wall-associated MPO catalyzed nitration of ECM protein tyrosine residues, with fibronectin identified as a major target protein.	Water	53-58	fibronectin 1	Mus musculus	172-183
29965781-7	2018	rab26-null mice showed further aggravation of the effects of endotoxin insult on lung vascular permeability and water content.	Water	112-117	RAB26, member RAS oncogene family	Mus musculus	0-5
11682148-5	2001	Thus the central effects of NPFF to decrease food intake may be largely attributable to increased water intake.	Water	98-103	neuropeptide FF-amide peptide precursor	Rattus norvegicus	28-32
28274814-2	2018	Aquaporin-4 (AQP4), the principal aquaporin expressed in the central nervous system (CNS, brain and spinal cord), has been shown to mediate CNS water homeostasis.	Water	144-149	aquaporin 4	Homo sapiens	0-11
28274814-2	2018	Aquaporin-4 (AQP4), the principal aquaporin expressed in the central nervous system (CNS, brain and spinal cord), has been shown to mediate CNS water homeostasis.	Water	144-149	aquaporin 4	Homo sapiens	13-17
11709086-5	2001	Although PTEN can utilize both phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] and its water-soluble headgroup, inositol 1,3,4,5-tetrakisphosphate, as substrates, it displays classical features of interfacial catalysis, which greatly favour the lipid substrate (by as much as 1000-fold as judged by K(cat)/K(m) values).	Water	100-105	phosphatase and tensin homolog	Homo sapiens	9-13
29756582-6	2018	METHODS: AQP-4 is an abundant channel water protein in brain that regulates water transport to prevent homeostasis.	Water	38-43	aquaporin 4	Homo sapiens	9-14
29756582-6	2018	METHODS: AQP-4 is an abundant channel water protein in brain that regulates water transport to prevent homeostasis.	Water	76-81	aquaporin 4	Homo sapiens	9-14
29756582-7	2018	Over-expression of AQP-4 contributes to water imbalance in ischemic pathology resulting in cerebral edema.	Water	40-45	aquaporin 4	Homo sapiens	19-24
11743870-5	2001	Similar internal water molecules were shown to be present in bovine rhodopsin.	Water	17-22	rhodopsin	Bos taurus	68-77
29405826-3	2018	Hyp dehydratase (HypD) catalyzes the removal of water from Hyp to generate Delta1-pyrroline-5-carboxylate (P5C).	Water	48-53	pyrroline-5-carboxylate reductase 1	Homo sapiens	81-105
29405826-3	2018	Hyp dehydratase (HypD) catalyzes the removal of water from Hyp to generate Delta1-pyrroline-5-carboxylate (P5C).	Water	48-53	pyrroline-5-carboxylate reductase 1	Homo sapiens	107-110
11894976-20	2001	In this period alcohol inhibited the secretion of leptin as shown by the leptin incremental area (AUC18-24) which was 53 +/- 18 after alcohol and 113 +/- 15 after water (P &lt; 0.01).	Water	163-168	leptin	Homo sapiens	50-56
29865052-8	2018	Lithium concentrations in tap water was significantly lower in rural counties compared to urban (63.3+-8.2 and 33.4+-4.7mug/L, respectively).	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
11894976-20	2001	In this period alcohol inhibited the secretion of leptin as shown by the leptin incremental area (AUC18-24) which was 53 +/- 18 after alcohol and 113 +/- 15 after water (P &lt; 0.01).	Water	163-168	leptin	Homo sapiens	73-79
11855171-2	2001	The paper reviews the sustainable reaction and separation processes in S/NCF solvents such as supercritical carbon dioxide and near-critical water.	Water	141-146	neutrophil cytosolic factor 4	Homo sapiens	73-76
29040585-1	2018	Objectives: This study identified and characterized mcr-1-positive Enterobacteriaceae (MCRPE) and carbapenemase-producing Enterobacteriaceae (CPE) in hospital sewage water.	Water	166-171	OXA-48	Klebsiella pneumoniae	98-111
11765789-3	2001	With increase in w0 (water amount), the equilibrium is shifted towards the MC, protonated at -NMe2 group (MC1) and MC3 in the S0 state.	Water	21-26	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	94-98
29382548-8	2018	RESULTS: After six weeks, uninephrectomized rats that were kept on high salt drinking water shown significant increase (P &lt; 0.001) in MAP, PP and PWV indicates that hypertension along with elevated PP developed in rats, and increase in collagen/elastin ratio (P &lt; 0.001) as well as PWV as compared to normal rats indicates the increase in AS.	Water	86-91	elastin	Rattus norvegicus	248-255
23686875-1	2001	The potential activation by electron capture of H2+CO2 or CO+H2O reactions, leading to HCOOH (formic acid), and of CO+NH3, HCN+H2O and HNC+H2O reactions, leading to HC(O)NH2 (formamide), have been studied theoretically.	Water	61-64	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	123-126
29320331-1	2018	Neuromyelitis optica (NMO) is an autoimmune demyelinating disorder for which the aquaporin-4 (AQP4) water channels are the major target antigens.	Water	100-105	aquaporin 4	Homo sapiens	81-92
29320331-1	2018	Neuromyelitis optica (NMO) is an autoimmune demyelinating disorder for which the aquaporin-4 (AQP4) water channels are the major target antigens.	Water	100-105	aquaporin 4	Homo sapiens	94-98
29304558-0	2018	Reduction of FENO by tap water and carbonated water mouthwashes: magnitude and time course.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
23686875-1	2001	The potential activation by electron capture of H2+CO2 or CO+H2O reactions, leading to HCOOH (formic acid), and of CO+NH3, HCN+H2O and HNC+H2O reactions, leading to HC(O)NH2 (formamide), have been studied theoretically.	Water	127-130	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	123-126
29304558-8	2018	The tap water mouthwash reduced FENO statistically significantly only for 2 min compared with the baseline.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
23686875-1	2001	The potential activation by electron capture of H2+CO2 or CO+H2O reactions, leading to HCOOH (formic acid), and of CO+NH3, HCN+H2O and HNC+H2O reactions, leading to HC(O)NH2 (formamide), have been studied theoretically.	Water	127-130	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	123-126
11855760-3	2001	The policemen ran straight into the water to pull a small speedboat up on to the beach.	Water	36-41	RAN, member RAS oncogene family	Homo sapiens	14-17
11560872-9	2001	Linear correlation analyses between UGT1A4 kinetics and substrate physicochemical parameters showed significant correlation between V(max) and both the partition coefficient (log P, n-octanol/water) and pK(a) and between K(m) and pK(a), thereby indicating that the lipophilicity and the ease of availability of the tertiary amine lone pair of electrons of the substrate are important with respect to enzyme catalysis.	Water	192-197	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	36-42
11596746-5	2001	The partition coefficients between the solid phase of the sediment versus the interstitial water are very different for LAS and for its degradation intermediates.	Water	91-96	lipoic acid synthetase	Homo sapiens	120-123
11576848-6	2001	IL-2 therapy alone reduced tumour growth and metastasis, but caused significant water retention indicative of capillary leakage in the kidneys after both rounds of therapy, whereas pleural effusion was only evident after the first round and not the second round.	Water	80-85	interleukin 2	Mus musculus	0-4
28264554-3	2017	The mNGF dissolved in distilled water or distilled water alone was given to the mice once every other day from P7 by intramuscular injection in the hips.	Water	32-37	nerve growth factor	Mus musculus	4-8
11502603-1	2001	The vasopressin-induced trafficking of aquaporin-2 (AQP2) water channels in kidney collecting duct is likely mediated by vesicle-targeting proteins (N-ethylmaleimide-sensitive factor attachment protein receptors).	Water	58-63	aquaporin 2	Rattus norvegicus	52-56
11518698-0	2001	Aquaporin-2, a regulated water channel, is expressed in apical membranes of rat distal colon epithelium.	Water	25-30	aquaporin 2	Rattus norvegicus	0-11
28778975-0	2017	EHD4 is a novel regulator of urinary water homeostasis.	Water	37-42	EH-domain containing 4	Mus musculus	0-4
28778975-5	2017	Urine excretion after an acute intraperitoneal water load was significantly increased in EHD4-KO mice compared to WT mice, and although EHD4-KO mice concentrated their urine during 24-h water restriction, urinary osmolality remained significantly lower than in WT mice, suggesting that EHD4 plays a role in renal water handling.	Water	47-52	EH-domain containing 4	Mus musculus	89-93
28778975-9	2017	EHD4 is a novel regulator of urinary water homeostasis.	Water	37-42	EH-domain containing 4	Mus musculus	0-4
11518698-1	2001	Aquaporin-2 (AQP-2) is the vasopressin-regulated water channel expressed in the apical membrane of principal cells in the collecting duct and is involved in the urinary concentrating mechanism.	Water	49-54	aquaporin 2	Rattus norvegicus	0-11
11518698-1	2001	Aquaporin-2 (AQP-2) is the vasopressin-regulated water channel expressed in the apical membrane of principal cells in the collecting duct and is involved in the urinary concentrating mechanism.	Water	49-54	aquaporin 2	Rattus norvegicus	13-18
11518698-8	2001	Water deprivation increased the hybridization signal and the protein level (assessed by Western blot analysis) for AQP-2 in distal colon.	Water	0-5	aquaporin 2	Rattus norvegicus	115-120
28940861-7	2017	Thus, Ang-(1-7)-induced increases in sodium and water excretion are dependent upon functional Mas and AT1 receptors.	Water	48-53	angiogenin	Rattus norvegicus	6-14
11518698-10	2001	These results indicate that AQP-2 is present in the rat distal colon, where it might be involved in a water-sparing mechanism.	Water	102-107	aquaporin 2	Rattus norvegicus	28-33
11518698-11	2001	In addition, these results support the idea that AQP-2, and probably other aquaporins, are involved in water absorption in the colon.	Water	103-108	aquaporin 2	Rattus norvegicus	49-54
11676192-11	2001	Actually the aquaporin-4 water channel has been found to colocalize with Kir4.1 in retinal glial cells.	Water	25-30	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	73-79
28562156-6	2017	RESULTS: Neuritin significantly improved the neurological scores, brain water content, blood-brain barrier (BBB) and apoptosis compared with the control and sham groups within 24 h after SAH.	Water	72-77	neuritin 1	Rattus norvegicus	9-17
11511198-2	2001	Compounds 1 and 2 are isomorphous and exhibit the general formula [Co2(dpk-OH)(dpk-CH3O)(L)(H2O)]2A2-4H2O where dpk = di-2-pyridyl ketone, L = N3(-) and A = BF4(-) for 1, and L = NCO(-) and A = ClO4(-) for 2.	Water	92-95	potassium two pore domain channel subfamily K member 1	Homo sapiens	79-82
29071784-5	2017	Recovery studies were also performed to show the applicability of the developed methods, and percentage recovery values were found to be 90-105% in tap water and 94-97% in wastewater for both analytes.	Water	152-157	nuclear RNA export factor 1	Homo sapiens	148-151
11511198-2	2001	Compounds 1 and 2 are isomorphous and exhibit the general formula [Co2(dpk-OH)(dpk-CH3O)(L)(H2O)]2A2-4H2O where dpk = di-2-pyridyl ketone, L = N3(-) and A = BF4(-) for 1, and L = NCO(-) and A = ClO4(-) for 2.	Water	92-95	potassium two pore domain channel subfamily K member 1	Homo sapiens	79-82
29117136-4	2017	Water-soluble magnetofluid with Fe3O4 nanoparticles incorporated in the inner aqueous core of CLC shells is responsible for the non-invasive transportable capability.	Water	0-5	Charcot-Leyden crystal galectin	Homo sapiens	94-97
11511198-3	2001	The ligands dpk-OH(-) and dpk-CH3O(-) result from solvolysis and ulterior deprotonation of dpk in water and methanol, respectively.	Water	98-103	potassium two pore domain channel subfamily K member 1	Homo sapiens	12-15
11511198-3	2001	The ligands dpk-OH(-) and dpk-CH3O(-) result from solvolysis and ulterior deprotonation of dpk in water and methanol, respectively.	Water	98-103	potassium two pore domain channel subfamily K member 1	Homo sapiens	26-29
11511198-3	2001	The ligands dpk-OH(-) and dpk-CH3O(-) result from solvolysis and ulterior deprotonation of dpk in water and methanol, respectively.	Water	98-103	potassium two pore domain channel subfamily K member 1	Homo sapiens	26-29
29043337-7	2017	The dication [({mu2-ROF}Sr (H2O))2]2+ exists as an O-bridged dinuclear species featuring very strong intramolecular SrF-C interactions in the range 2.788(5)-2.997(6) A, and no interaction with the weakly coordinating anion.	Water	28-31	serum response factor	Homo sapiens	116-119
11390403-0	2001	Photosynthetic water oxidation in cytochrome b(559) mutants containing a disrupted heme-binding pocket.	Water	15-20	cytochrome b	Chlamydomonas reinhardtii	34-46
28800414-9	2017	Well water and tap water contained relatively higher PFC concentrations than other types of drinking water.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
28800414-9	2017	Well water and tap water contained relatively higher PFC concentrations than other types of drinking water.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
11476728-4	2001	(i) Increase in water permeability along the entire CD (via AQP2).	Water	16-21	aquaporin 2	Homo sapiens	60-64
28890359-5	2017	Both reduced activity and OPA1 binding of CIV were rescued by water-solubilized CoQ10 administration to aged mice via drinking water.	Water	62-67	OPA1, mitochondrial dynamin like GTPase	Mus musculus	26-30
28890359-5	2017	Both reduced activity and OPA1 binding of CIV were rescued by water-solubilized CoQ10 administration to aged mice via drinking water.	Water	127-132	OPA1, mitochondrial dynamin like GTPase	Mus musculus	26-30
11531928-0	2001	Urinary excretion of the aquaporin-2 water channel exaggerated in pathological states of impaired water excretion.	Water	37-42	aquaporin 2	Homo sapiens	25-36
28738625-0	2017	The screening of organic matter in mineral and tap water by UHPLC-HRMS.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
28738625-6	2017	This UHPLC-HRMS method was developed and tested with tap water and mineral water.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
11531928-4	2001	Urinary excretion of AQP-2 under ad libitum water drinking was 41.1 fmol/micromol creatinine in the patient group, a value significantly greater than that of 21.7 fmol/micromol creatinine in the control subjects.	Water	44-49	aquaporin 2	Homo sapiens	21-26
28732945-1	2017	The present work focuses on possible heat transfer enhancement from a heating plate towards tap water in forced convection by means of 2MHz ultrasound.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
11483618-1	2001	LPL, like other lipases, has the ability to hydrolyze water-insoluble lipid substrates, but the mechanism is incompletely understood.	Water	54-59	lipoprotein lipase	Homo sapiens	0-3
29022639-1	2017	Glucose oxidase (GOx) and polyacrylic acid (PAA) based water swellable non-toxic enzyme-polymer conjugate (PAA-GOx) was immobilized on a substrate consisting of graphene oxide (GO) and polyethyleneimine (PEI) (GO-PEI) and the electrochemical performances of the new catalyst were investigated.	Water	55-60	hydroxyacid oxidase 1	Homo sapiens	111-114
11483618-13	2001	Specific point mutations or deletion of the region between the hydrophobic stretches (LPL419-430) caused up to 90% selective loss of hydrolyzing activity against water-insoluble triolein, but not against water-soluble tributyrin, implicating a crucial function for LPL419-430 in the interaction with lipid substrates.	Water	162-167	lipoprotein lipase	Homo sapiens	86-89
11511792-8	2001	These results indicate an altered regulation of AQP2 water channels in the clipped kidney in 2K1C hypertension.	Water	53-58	aquaporin 2	Rattus norvegicus	48-52
29066817-3	2017	MIF increased biomass by 10% and grain yield by 21%, thereby achieving a 17% increase in water use efficiency (WUE) and a 22% increase in precipitation use efficiency (PUE) compared with conventional flat planting (CKM).	Water	89-94	macrophage migration inhibitory factor	Zea mays	0-3
11473638-9	2001	Raising the media osmolality from a normal level to 500 or 600 mOsm/kg H2O final osmolality elicited apoptotic changes such as nucleosomal laddering of DNA and an increment of caspase-3 activity and increased activity in the cell death enzyme-linked immunosorbent assay.	Water	71-74	caspase 3	Canis lupus familiaris	176-185
29066817-4	2017	MIF also improved irrigation water use efficiency (IWUE) (9%) and irrigation water productivity (IWP) (46%) compared with no-irrigation under the RFRH system (MI0).	Water	29-34	macrophage migration inhibitory factor	Zea mays	0-3
28741840-2	2017	Fullerenes bicapped by gamma-CD were mixed with presynthesized nCx in the presence of poly(ethylene glycol) (PEG) in water.	Water	117-122	T cell leukemia homeobox 2	Homo sapiens	63-66
30099420-7	2018	RESULTS: Results: When studying the content of methemoglobin among adult population in village areas, where well water with a high concentration of nitrates is consumed and in the city where centralized water supply is used, it was observed that rural people have a higher level of methemoglobin.	Water	113-118	hemoglobin subunit gamma 2	Homo sapiens	47-60
11512615-2	2001	The present primary standard of absorbed dose to water for NRC, Canada is based on measurements made with a sealed water calorimeter.	Water	49-54	nuclear receptor coactivator 6	Homo sapiens	59-62
11468361-0	2001	Molecular mimicry of substrate oxygen atoms by water molecules in the beta-amylase active site.	Water	47-52	beta-amylase	Glycine max	70-82
29326556-0	2017	The Oxidative Stress-Induced Increase in the Membrane Expression of the Water-Permeable Channel Aquaporin-4 in Astrocytes Is Regulated by Caveolin-1 Phosphorylation.	Water	72-77	aquaporin 4	Homo sapiens	96-107
29326556-2	2017	Apart from inflicting oxidative damage, the latter may also trigger the upregulation of aquaporin 4 (AQP4), a water-permeable channel expressed by astroglial cells of the blood-brain barrier (BBB), and contribute to edema formation, the severity of which is known to be the primary determinant of mortality and morbidity.	Water	110-115	aquaporin 4	Homo sapiens	88-99
29326556-2	2017	Apart from inflicting oxidative damage, the latter may also trigger the upregulation of aquaporin 4 (AQP4), a water-permeable channel expressed by astroglial cells of the blood-brain barrier (BBB), and contribute to edema formation, the severity of which is known to be the primary determinant of mortality and morbidity.	Water	110-115	aquaporin 4	Homo sapiens	101-105
29326556-10	2017	Together, these findings suggest that oxidative stress-induced Cav1 phosphorylation modulates AQP4 subcellular distribution and therefore may indirectly regulate AQP4-mediated water transport.	Water	176-181	aquaporin 4	Homo sapiens	94-98
29326556-10	2017	Together, these findings suggest that oxidative stress-induced Cav1 phosphorylation modulates AQP4 subcellular distribution and therefore may indirectly regulate AQP4-mediated water transport.	Water	176-181	aquaporin 4	Homo sapiens	162-166
29085343-8	2017	Both of these effects as well as the final wash-in of fresh tap water followed calculated predictions well.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
28994403-2	2017	Previous X-ray crystallographic analyses of HSP70 have shown that HSP70 binds to ADP with internal water molecules.	Water	99-104	heat shock protein family A (Hsp70) member 4	Homo sapiens	44-49
11468361-8	2001	The water structure at the active pocket of beta-amylase is therefore essential for providing the ligand recognition process with plasticity.	Water	4-9	beta-amylase	Glycine max	44-56
28994403-2	2017	Previous X-ray crystallographic analyses of HSP70 have shown that HSP70 binds to ADP with internal water molecules.	Water	99-104	heat shock protein family A (Hsp70) member 4	Homo sapiens	66-71
11401827-2	2001	In the principal cells of the kidney collecting duct, water reabsorption is mediated by the combined action of AQP2 in the apical membrane and both AQP3 and AQP4 in the basolateral membrane, and the expression of AQP2 and AQP3 is regulated by antidiuretic hormone and water restriction.	Water	54-59	aquaporin 2	Canis lupus familiaris	111-115
28994403-3	2017	In order to elucidate the role of the water molecules, including their H/D atoms, a neutron diffraction study of the human HSP70 ATPase domain was initiated.	Water	38-43	heat shock protein family A (Hsp70) member 4	Homo sapiens	123-128
28942945-3	2017	We previously reported that a water-soluble extract from G. lucidum fungus mycelia (MAK) has anti-inflammatory effects in murine colitis induced by trinitrobenzene sulfonic acid, and induction of granulocyte macrophage colony-stimulating factor (GM-CSF) by MAK may provide anti-inflammatory effects.	Water	30-35	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	196-244
28827359-5	2017	Deep UV second harmonic generation measurements of the SCN- ion, a prototypical chaotrope, determined a free energy of adsorption within error of that for air/water.	Water	159-164	sorcin	Homo sapiens	55-58
28942945-3	2017	We previously reported that a water-soluble extract from G. lucidum fungus mycelia (MAK) has anti-inflammatory effects in murine colitis induced by trinitrobenzene sulfonic acid, and induction of granulocyte macrophage colony-stimulating factor (GM-CSF) by MAK may provide anti-inflammatory effects.	Water	30-35	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	246-252
11401827-2	2001	In the principal cells of the kidney collecting duct, water reabsorption is mediated by the combined action of AQP2 in the apical membrane and both AQP3 and AQP4 in the basolateral membrane, and the expression of AQP2 and AQP3 is regulated by antidiuretic hormone and water restriction.	Water	54-59	aquaporin 2	Canis lupus familiaris	213-217
29236079-8	2017	An equivalent water molecule was found in many CK2alpha structures, but never as a critical mediator of ligand binding.	Water	14-19	casein kinase 2 alpha 2	Homo sapiens	47-55
29124937-11	2017	Finally, it is demonstrated that AgNW/TNC and AgNW/TNC on paper are water resistant for 15 min due to the insulation properties of the nonporous substrate.	Water	68-73	tenascin C	Homo sapiens	38-41
11401827-2	2001	In the principal cells of the kidney collecting duct, water reabsorption is mediated by the combined action of AQP2 in the apical membrane and both AQP3 and AQP4 in the basolateral membrane, and the expression of AQP2 and AQP3 is regulated by antidiuretic hormone and water restriction.	Water	268-273	aquaporin 2	Canis lupus familiaris	213-217
28714172-0	2017	A study of DNA damage in buccal cells of consumers of well- and/or tap-water using the comet assay: Assessment of occupational exposure to genotoxicants.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
28714172-5	2017	Taking into account the professions of well- and/or tap-water consumers, agricultural workers exposed directly (those who fumigated) or indirectly (those not involved in fumigating) to agrochemicals showed greater genetic damage than controls.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
11423416-2	2001	From these data a model is constructed that allows us to predict that 1) when subjected to an increasing protein osmotic pressure, myosin filaments experience an elastic deformation, which is not linearly related to the acting force; and 2) at constant protein osmotic pressure, when the cross-bridges of the myosin filaments are subjected to an external, nonosmotic force parallel to the filament axis, they are deformed and the water activity coefficient is altered.	Water	430-435	myosin heavy chain 14	Homo sapiens	131-137
28651147-7	2017	The unpleasant sensorial problems associated with desalinated drinking tap water may constitute the driving force for most people in GCC countries to depend on bottled water.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
28651147-7	2017	The unpleasant sensorial problems associated with desalinated drinking tap water may constitute the driving force for most people in GCC countries to depend on bottled water.	Water	168-173	nuclear RNA export factor 1	Homo sapiens	71-74
29124937-11	2017	Finally, it is demonstrated that AgNW/TNC and AgNW/TNC on paper are water resistant for 15 min due to the insulation properties of the nonporous substrate.	Water	68-73	tenascin C	Homo sapiens	51-54
11297561-1	2001	Mutations in the aquaporin-2 (AQP2) water channel cause the hereditary renal disease nephrogenic diabetes insipidus (NDI).	Water	36-41	aquaporin 2	Homo sapiens	17-28
29064954-0	2017	MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.	Water	63-68	MAS-related GPR, member A3	Mus musculus	0-7
29046302-6	2017	An ~50% reduction in the inhibitory effect of tea (relative to water) was observed, from 37.2% (TM-2) to 18.1% (TM-3).Conclusions: This study shows that tea consumed simultaneously with an iron-containing porridge meal leads to decreased nonheme iron absorption and that a 1-h time interval between a meal and tea consumption attenuates the inhibitory effect, resulting in increased nonheme iron absorption.	Water	63-68	tropomyosin 3	Homo sapiens	112-116
28651147-8	2017	To encourage people in the GCC countries to consume desalinated tap water, it is essential that water testing include measurements of physicochemical properties, biofilm presence and organoleptic parameters to improve overall water quality.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
28651147-9	2017	This review highlights the contribution of organoleptics for consumers of desalinated tap water.	Water	90-95	nuclear RNA export factor 1	Homo sapiens	86-89
28651147-11	2017	Accordingly, consumer awareness and outreach campaigns should be implemented to encourage people to drink tap water in the GCC countries.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	106-109
11297561-1	2001	Mutations in the aquaporin-2 (AQP2) water channel cause the hereditary renal disease nephrogenic diabetes insipidus (NDI).	Water	36-41	aquaporin 2	Homo sapiens	30-34
11414039-1	2001	We evaluated a method to determine organic carbon-normalized soil-water partition coefficients (Koc) of 20 PAHs and 12 PCBs by desorption in the presence of a cosolvent (methanol fractions of 0.1-0.9) and at different temperatures (20-80 degrees C).	Water	66-71	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	96-99
28846933-8	2017	The optimum catalyst indicated completely remove of MO dye with the 15mgL-1 concentration from the water after 50min photocatalytic reaction time, where for the optimum sample the removal efficiency was 77% after only 10min reaction.	Water	99-104	LLGL scribble cell polarity complex component 1	Homo sapiens	70-75
28755507-7	2017	Water stress triggers a pldalpha1-like phenotype in PLDrp1 mutants and induces the expression of PLDrp1 in pldalpha1 mutants.	Water	0-5	phospholipase D alpha 1	Arabidopsis thaliana	24-33
28975375-7	2017	The influence of potential main matrix constituents such as Na+, Ca2+, Mg2+, and Cl- as well as surface water sampling/storage conditions on the molecular absorption signal of GaF was investigated.	Water	104-109	fibroblast growth factor 9	Homo sapiens	176-179
12947673-6	2001	The method was successfully applied to determinate trace amounts of Cu2+, Pb2+, Cd2+ and Mn2+ species in drinking water and environment water samples.	Water	114-119	CD2 molecule	Homo sapiens	80-83
28658347-10	2017	In addition, in the MHS group, circulating RBP-4 was positively correlated with fat percentage and fat mass (FM) (p &lt; 0.0001) and was negatively correlated with fat-free mass (FFM) and total body water (TBW) (p &lt; 0.0001).	Water	199-204	retinol binding protein 4	Homo sapiens	43-48
28755507-7	2017	Water stress triggers a pldalpha1-like phenotype in PLDrp1 mutants and induces the expression of PLDrp1 in pldalpha1 mutants.	Water	0-5	phospholipase D alpha 1	Arabidopsis thaliana	107-116
28642133-3	2017	S-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has been demonstrated as a suppressive agent against tumors.	Water	43-48	solute carrier family 25 member 26	Homo sapiens	25-29
11278554-5	2001	Water immersion of rats for up to 6 h prevents supramaximal caerulein-induced pancreatic IkappaB-alpha degradation and NF-kappaB activation in vivo.	Water	0-5	NFKB inhibitor alpha	Rattus norvegicus	89-102
28928371-6	2017	Our results highlight a possibly general pathway that can be integrated to gel-spinning process, suggesting the hypothesis that that high stiffness, strength and toughness can be achieved simultaneously, if the alignment is induced while the CNF are in the free-flowing state during the extrusion step by shear at relatively low concentration and in pure water, after which they can be coagulated.	Water	355-360	NPHS1 adhesion molecule, nephrin	Homo sapiens	242-245
28922632-6	2017	After the coating of SAP3-TA on HA slices, the water contact angle is decreased to 14.2  and the HA surface becomes super-hydrophilic.	Water	47-52	ganglioside GM2 activator	Homo sapiens	21-25
28836062-7	2017	Morris water maze test showed that CCH induced decline in learning and memory related to Abeta levels in the hippocampus.	Water	7-12	amyloid beta precursor protein	Rattus norvegicus	89-94
11246206-3	2001	Force constants were scaled using the experimentally determined Raman and Fourier transform infrared vibrational frequencies of four isotopic species of Ala-Ala in water at pH 13 and pH 1.	Water	164-169	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	173-177
28942244-1	2017	A massive spill of 4-methylcyclohexanemethanol (MCHM), a semi-volatile organic compound, contaminated the Elk river and forced the recent closure of tap water for nearly 300,000 residents.	Water	153-158	nuclear RNA export factor 1	Homo sapiens	149-152
29184031-6	2017	Analysis of the constitutively open Orai1 mutant channels revealed two fundamental gates that enabled Ca2+ influx: Arginine side chains were displaced so they no longer blocked the pore, and a chain of water molecules formed in the hydrophobic pore region.	Water	202-207	ORAI calcium release-activated calcium modulator 1	Homo sapiens	36-41
28904338-1	2017	Stable water-soluble copper sulfide(Cu2S) quantum dots(QDs) with near-infrared emission were synthesized using N-acetyl-L-cysteine(NAC) as a modifier in aqueous solution and nitrogen atmosphere at room temperature.	Water	7-12	X-linked Kx blood group	Homo sapiens	131-134
28666065-1	2017	We describe two water-soluble ruthenium complexes, [1]Cl2 and [2]Cl2 , that photodissociate to release a cytotoxic nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a low dose (21 J cm-2 ) of red light in an oxygen-independent manner.	Water	16-21	endogenous retrovirus group W member 5	Homo sapiens	54-57
28666065-1	2017	We describe two water-soluble ruthenium complexes, [1]Cl2 and [2]Cl2 , that photodissociate to release a cytotoxic nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a low dose (21 J cm-2 ) of red light in an oxygen-independent manner.	Water	16-21	endogenous retrovirus group W member 5	Homo sapiens	65-68
28864188-5	2017	This sensing system allowed the accurate classification of nine metal ions in pure water at 0.5 muM and tap water at 3.0 muM.	Water	108-113	nuclear RNA export factor 1	Homo sapiens	104-107
11246206-5	2001	All but one scale factor were directly transferable between the pH 1 and pH 13 species for coordinates unchanged by protonation in both the isolated and two-water supermolecule structures.	Water	157-162	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	64-68
11472112-9	2001	From the results, the conserved water molecule, corresponding to W206 in the E. coli DHFR complexes, that is H-bonded to both the OD2 oxygen atom of the carboxyl (Asp) side chain and O4 of the pterin/dihydropterin ring, appears critically important and may determine the protonation site for the enzyme-bound substrates.	Water	32-37	Dihydrofolate reductase	Escherichia coli	85-89
28727528-0	2017	Racial/Ethnic and Socioeconomic Disparities in Hydration Status Among US Adults and the Role of Tap Water and Other Beverage Intake.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
11401515-1	2001	Aquaporin-2 (AQP2) water channel mutations cause autosomal recessive and dominant nephrogenic diabetes insipidus (NDI).	Water	19-24	aquaporin 2	Homo sapiens	0-11
28411128-5	2017	Beta-adrenergic receptor agonist-treated pups allowed the determination whether there were neuroanatomical correlates within the neural substrates controlling thirst and the enhanced water intake evidenced by the isoproterenol treated pups of PAL mothers.	Water	183-188	leucine-rich repeat, Ig-like and transmembrane domains 1	Rattus norvegicus	243-246
28411128-7	2017	Higher salt and water intakes along with blood pressures and heart rates were found during gestation and lactation in the M-PAL group.	Water	16-21	leucine-rich repeat, Ig-like and transmembrane domains 1	Rattus norvegicus	122-127
28411128-9	2017	These results indicate that PAL is compatible with pregnancy, producing a sustained increase in blood pressure and heart rate, along with increased water and salt intake.	Water	148-153	leucine-rich repeat, Ig-like and transmembrane domains 1	Rattus norvegicus	28-31
29186890-4	2017	In conclusion, urinary As III, As V, MMA, and hair arsenic concentrations were significantly higher in residents who consumed arsenic contaminated ground water than control participants who consumed tap water.	Water	203-208	nuclear RNA export factor 1	Homo sapiens	199-202
29127701-4	2017	This study aims to investigate if somatostatin monomers are released from physical hydrogels formed in water and in the presence of electrolytes.	Water	103-108	somatostatin	Homo sapiens	34-46
11401515-1	2001	Aquaporin-2 (AQP2) water channel mutations cause autosomal recessive and dominant nephrogenic diabetes insipidus (NDI).	Water	19-24	aquaporin 2	Homo sapiens	13-17
11247842-7	2001	A comparison of 1- to 2-day water deprivation showed that plasma VP, brain c-Fos, and VP mRNA returned toward control on day 2, although plasma osmolality remained high.	Water	28-33	FBJ osteosarcoma oncogene	Mus musculus	75-80
26923686-0	2017	Perineal tap water burns in the elderly: at what cost?	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
28628832-1	2017	This study investigated the effects young leaves of reed (Phragmites communis) water extract (YLR) on melanogenesis and oxidative stress using B16F10 cells.	Water	79-84	Y-linked B cell surface antigen	Mus musculus	94-97
11256996-13	2001	All these data show that aquaporin-4 expression occurs in the chick embryonic brain, in parallel with maturation and functioning of the blood-brain barrier and suggest that there is a close relationship between water transport regulation and brain development.	Water	211-216	aquaporin 4	Gallus gallus	25-36
28555336-0	2017	A Novel Liquid-Liquid Extraction for the Determination of Sertraline in Tap Water and Waste Water at Trace Levels by GC-MS. A simple, green and fast analytical method was developed for the determination of sertraline in tap and waste water samples at trace levels by using supportive liquid-liquid extraction with gas chromatography-mass spectrometry.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
28555336-7	2017	The spiking experiments yielded satisfactory recoveries of 91.19 +- 2.48%, 90.48 +- 5.19% and 95.46 +- 6.56% for 100, 250 and 500 ng/mL sertraline for tap water, and 85.80 +- 2.15% and 92.43 +- 4.02% for 250 and 500 ng/mL sertraline for waste water.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	151-154
28958189-3	2017	Lectin blot analysis of a series of commercial water-soluble elastin preparations, PES-(A) ~ PES-(E), revealed that only PES-(E) contained substances recognized by Gal-9.	Water	47-52	elastin	Homo sapiens	61-68
28214585-5	2017	The water content of the CNF/gelatin composite film increased linearly as the gelatin content increased.	Water	4-9	NPHS1 adhesion molecule, nephrin	Homo sapiens	25-28
11285328-0	2001	Fermented soybean-derived water-soluble Touchi extract inhibits alpha-glucosidase and is antiglycemic in rats and humans after single oral treatments.	Water	26-31	sucrase-isomaltase	Homo sapiens	64-81
28642114-1	2017	A water soluble Antrodia Camphorata polysaccharide was composed of beta-d-glucan, coded as ACP1.	Water	2-7	acid phosphatase 1	Homo sapiens	91-95
11285328-1	2001	A water-soluble extract of Touchi, a traditional Chinese food, was found to exert a strong inhibitory activity against rat intestinal alpha-glucosidase.	Water	2-7	sucrase-isomaltase	Homo sapiens	134-151
29340488-1	2017	OBJECTIVE: To determine whether different levels of CPAP improve the lung volumes and capacities of healthy subjects immersed in water.	Water	129-134	centromere protein J	Homo sapiens	52-56
11171646-5	2001	Water intake was increased during intracerebroventricular infusion of hypertonic mannitol and somatostatin.	Water	0-5	somatostatin	Ovis aries	94-106
11124908-13	2001	NPY is located at the lipid-water interface with its C-terminal helix parallel to the membrane surface and penetrates the hydrophobic interior only via insertions of a few long aliphatic or aromatic side-chains.	Water	28-33	neuropeptide Y	Homo sapiens	0-3
28978666-1	2017	Water channel aquaporin 4 (AQP4) plays a key role in the regulation of water homeostasis in the brain.	Water	71-76	aquaporin 4	Homo sapiens	27-31
28978666-10	2017	For the first time, this study demonstrates an active role of AQP4e in the regulation of OAP structural dynamics and in water homeostasis.SIGNIFICANCE STATEMENT Water channel aquaporin 4 (AQP4) plays a key role in the regulation of water homeostasis in the brain.	Water	120-125	aquaporin 4	Homo sapiens	62-66
28612149-8	2017	Most wounds healed by secondary intention and were managed using simple tap water-moistened plain gauze dressings changed three times a day.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
11205022-6	2001	A temperature-dependent (17)O NMR study of bulk water linewidths for solutions of the Gd3+ complexes provided direct evidence for differences in water exchange rates for the two coordination isomers.	Water	48-53	GRDX	Homo sapiens	86-89
11205022-6	2001	A temperature-dependent (17)O NMR study of bulk water linewidths for solutions of the Gd3+ complexes provided direct evidence for differences in water exchange rates for the two coordination isomers.	Water	145-150	GRDX	Homo sapiens	86-89
11205022-7	2001	The bound-water lifetimes (tauM298) in the M and m isomers of the Gd3+ complexes ranged from 1.4-2.4 micros and 3-14 ns, respectively.	Water	10-15	GRDX	Homo sapiens	66-69
12718659-2	2001	However, the species of glutathione S-transferases (GSTP1-1) linked to neoplasia of rat and human were recently shown to be selective for hydrophilic carcinogens such as acrolein and hydroxyalkenals (Satoh, 1998; Satoh et al., 1999) in accord with the finding of a water-network in the active site of the human GSTP1-1 by X-ray analysis (Hu et al.	Water	265-270	glutathione S-transferase pi 1	Homo sapiens	311-318
28718966-4	2017	Initially, catalyst Ag2 CO3 coordinates preferentially with internal N atom of TMS-N3 to assist water as hydrogen source and proton-shuttle in facilitating HN3 formation.	Water	96-101	MT-RNR2 like 3 (pseudogene)	Homo sapiens	156-159
28718966-8	2017	Water molecule plays an important role as proton shuttle to promote HN3 and key active silver acetylides formation, thus improving the yield of product.	Water	0-5	MT-RNR2 like 3 (pseudogene)	Homo sapiens	68-71
29023569-9	2017	Pancreatic PLA2 interacted similarly with these targets; moreover, it inhibited radioactive alpha-bungarotoxin binding to the water-soluble extracellular domain of human alpha9 nAChR, and blocked acetylcholine induced currents in human alpha9alpha10 nAChRs heterologously expressed in Xenopus oocytes.	Water	126-131	phospholipase A2 group IIA	Homo sapiens	11-15
11338776-3	2001	It was found that OCT, while completely insoluble in water, forms solid gel structures when in equimolar mixtures of water and methanol.	Water	53-58	plexin A2	Homo sapiens	18-21
28905623-0	2017	Electropumping of Water Through Human Aquaporin 4 by Circularly Polarized Electric Fields: Dramatic Enhancement and Control Revealed by Non-Equilibrium Molecular Dynamics.	Water	18-23	aquaporin 4	Homo sapiens	38-49
11338776-3	2001	It was found that OCT, while completely insoluble in water, forms solid gel structures when in equimolar mixtures of water and methanol.	Water	117-122	plexin A2	Homo sapiens	18-21
11509828-9	2001	CONCLUSIONS: Our findings suggest that a non-AVP factor present in pregnancy plays a role in the control of the excretion of AQP-2 water channels.	Water	131-136	aquaporin 2	Homo sapiens	125-130
28801268-3	2017	Water-soluble functionalized C60 conjugates were radio-labeled with 64Cu and modified with cyclo (Arg-Gly-Asp) peptides (cRGD) for targeting of integrin alphavbeta3 in glioblastoma.	Water	0-5	integrin subunit alpha V	Homo sapiens	144-164
11505902-9	2001	Water-soluble substances, which are usually considered to be of no concern, may enter the sea in great amounts and, if not degradable, remain there.	Water	0-5	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	90-93
28574576-1	2017	KEY POINTS: Progressive depletion of all vascular endothelial growth factor A (VEGF-A) splice isoforms from the kidney results in proteinuria and increased glomerular water permeability, which are both rescued by over-expression of VEGF-A165 b only.	Water	167-172	vascular endothelial growth factor A	Mus musculus	41-77
28574576-1	2017	KEY POINTS: Progressive depletion of all vascular endothelial growth factor A (VEGF-A) splice isoforms from the kidney results in proteinuria and increased glomerular water permeability, which are both rescued by over-expression of VEGF-A165 b only.	Water	167-172	vascular endothelial growth factor A	Mus musculus	79-85
11719004-9	2001	The coexpression of MCT2 and aquaporin 4 suggests a possible role for MCT2 in regulating transcellular water movement.	Water	103-108	solute carrier family 16 member 7	Homo sapiens	20-24
28574576-8	2017	In the present study, we show, in a quad-transgenic model, that over-expression of VEGF-A165 b alone is sufficient to rescue the increase in proteinuria, as well as glomerular water permeability, in the context of progressive depletion of all VEGF-A isoforms from the podocytes.	Water	176-181	vascular endothelial growth factor A	Mus musculus	83-89
28682000-3	2017	In this work, we show a new approach based on para enriched hydrogen (p-H2 ) that enables the hyperpolarization of bulk water if a suitable catalytic system is employed.	Water	120-125	polyhomeotic homolog 2	Homo sapiens	70-74
11719004-9	2001	The coexpression of MCT2 and aquaporin 4 suggests a possible role for MCT2 in regulating transcellular water movement.	Water	103-108	solute carrier family 16 member 7	Homo sapiens	70-74
11209869-1	2001	The vibrational spectrum of H2O was calculated at MP2/6-31G(extended) and MP2/6-311G* levels taking into account anharmonicities through a simple approach to second-order perturbation theory in which molecular energy and dipole moment are expanded as Taylor series in normal coordinates with no cross terms, to simplify calculations.	Water	28-31	tryptase pseudogene 1	Homo sapiens	50-53
28735099-1	2017	Aquaporin-4 (AQP4) is the predominant water channel in mammalian CNS where it is localized at the perivascular astrocytic foot processes abutting brain microvessels.	Water	38-43	aquaporin 4	Homo sapiens	0-11
28735099-1	2017	Aquaporin-4 (AQP4) is the predominant water channel in mammalian CNS where it is localized at the perivascular astrocytic foot processes abutting brain microvessels.	Water	38-43	aquaporin 4	Homo sapiens	13-17
28735099-11	2017	This would leave the SN more prone to water accumulation and supports the idea that AQP4 could be involved in the pathogenesis of PD.	Water	38-43	aquaporin 4	Mus musculus	84-88
11209869-1	2001	The vibrational spectrum of H2O was calculated at MP2/6-31G(extended) and MP2/6-311G* levels taking into account anharmonicities through a simple approach to second-order perturbation theory in which molecular energy and dipole moment are expanded as Taylor series in normal coordinates with no cross terms, to simplify calculations.	Water	28-31	tryptase pseudogene 1	Homo sapiens	74-84
11724500-7	2001	WASP was able to accurately simulate the water hydrodynamics and coliform concentrations within the North Fork, while the neural network assisted in identifying correlations between fecal coliform and the various parameters involved.	Water	41-46	WASP actin nucleation promoting factor	Homo sapiens	0-4
28774174-4	2017	No false-positive response is generated when the sensors are placed in simulated and actual tap water contaminated by heavy metals.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
28520217-8	2017	Alterations in the expression of the AQP4/Kir4.1 complex can disrupt water and ion homeostasis, which may influence brain development and facilitate brain oedema formation This may be especially unfavourable during the first weeks of life.	Water	69-74	aquaporin 4	Homo sapiens	37-41
28588096-10	2017	In high-fat, high-sugar-fed rats, subchronic central beta3AR stimulation reduced body weight, chow, lard, and sucrose water intake, in addition to increasing browning of IWAT and GWAT.	Water	118-123	adrenoceptor beta 3	Rattus norvegicus	53-60
11167006-0	2000	A novel repeated sequence DNA originated from a Tc1-like transposon in water green frog Rana esculenta.	Water	71-76	transcobalamin 1	Homo sapiens	48-51
11188692-8	2000	Gly-60 and Gly-13 may play direct catalytic roles and stabilize the attacking water molecule and beta,gamma-bridging oxygen, respectively, in p21.	Water	78-83	H3 histone pseudogene 16	Homo sapiens	142-145
28616863-5	2017	KEY RESULTS: A water-soluble PIP2 analogue (diC8-PIP2 ) activated TMEM16A channels by up to fivefold and inhibited TMEM16B by ~0.2-fold.	Water	15-20	anoctamin 2b	Danio rerio	115-122
11093954-2	2000	In this study, our aim was to investigate whether the intraperitoneal administration of a nonpeptide neurokinin-1 (NK-1) antagonist, CP-96345, which antagonizes the binding of SP to its NK-1 receptor, results in the attenuation of colonic inflammation induced in rats by 5% dextran sodium sulfate (DSS) in drinking water for 10 days compared with an inactive enantiomer, CP-96344.	Water	315-320	tachykinin receptor 1	Rattus norvegicus	186-199
28435056-0	2017	Interfacial shear rheology of beta-lactoglobulin-Bovine submaxillary mucin layers adsorbed at air/water interface.	Water	98-103	beta-lactoglobulin	Bos taurus	30-48
29104916-3	2017	Water-soluble and biocompatible metal complexes with a significant degree of spin-orbit coupling were identified as target candidates for testing our new hypothesis.	Water	0-5	spindlin 1	Homo sapiens	77-81
11062334-1	2000	Guanylin (GN) and uroguanylin (UGN) are two recently identified peptides that have been shown to affect water and electrolyte transport in both the intestine and the kidney.	Water	104-109	guanylate cyclase activator 2B	Rattus norvegicus	18-29
29244884-1	2017	An innovative biological energy has been observed related to the eye sight and fusing with another energy over tap water through a small metallic chain.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
28964105-0	2017	Deep-water measurements of container ship radiated noise signatures and directionality.	Water	5-10	inositol polyphosphate-5-phosphatase D	Homo sapiens	37-41
11073261-2	2000	The charge state distributions of cytochrome c and myoglobin, formed from 47%/50%/3% water/solvent/acetic acid solutions, shift to lower charge (higher m/z) when the 50% solvent fraction is changed from water to methanol, to acetonitrile, to isopropanol.	Water	85-90	myoglobin	Homo sapiens	51-60
28698946-5	2017	The remarkable enhancement of the luminescence intensity of nano optical sensor [Sm-(DC)2]+ complex in water at 645 nm by the addition of various concentrations of H2O2 was successfully used as an optical sensor for the assessment of the activity of the glucose oxidase enzyme in different diabetics serum samples.	Water	103-108	hydroxyacid oxidase 1	Homo sapiens	254-269
28435056-3	2017	All protein layers (BLG, BSM, and BLG-BSM mixtures) formed an elastic network at the air/water interface with low frequency dependence of the interfacial modulus.	Water	89-94	beta-lactoglobulin	Bos taurus	20-23
28435056-3	2017	All protein layers (BLG, BSM, and BLG-BSM mixtures) formed an elastic network at the air/water interface with low frequency dependence of the interfacial modulus.	Water	89-94	beta-lactoglobulin	Bos taurus	34-37
28435056-6	2017	It is suggested that hydrophobic patches of BSM can be imbedded into the BLG monolayer as driven by a strong hydrophobic interaction with air and disrupt the cohesive assembly of BLG, whereas the hydrophilic (negatively charged) parts of the BSM chain are protruding from the interface towards the bulk water.	Water	303-308	beta-lactoglobulin	Bos taurus	73-76
11073261-2	2000	The charge state distributions of cytochrome c and myoglobin, formed from 47%/50%/3% water/solvent/acetic acid solutions, shift to lower charge (higher m/z) when the 50% solvent fraction is changed from water to methanol, to acetonitrile, to isopropanol.	Water	203-208	myoglobin	Homo sapiens	51-60
28576044-6	2017	The water contact angle, SEM, EDS and XPS confirmed that DNase I was successfully coated to the bare Ti and the final coating was highly hydrophilic.	Water	4-9	deoxyribonuclease I	Mus musculus	57-64
11042041-0	2000	Protein hydration and location of water molecules in oxidized horse heart cytochrome c by (1)H NMR.	Water	34-39	cytochrome c, somatic	Equus caballus	74-86
28857060-8	2017	More than a decade of water safety planning using the WSP approach has shown that supplying safe drinking water at the tap throughout the WHO South-East Asia Region is a realistic goal.	Water	106-111	nuclear RNA export factor 1	Homo sapiens	119-122
28953480-3	2017	Total exported flows out of the system were 78,528 Mm3 y-1 including outflow into the lower Chao Phraya River and tap water (TW) distributed to suburbs.	Water	118-123	putative ABC-transporter	Sus scrofa	114-117
11042041-6	2000	The identification of hydrophilic regions and detection of three long-lived water molecules settles some ambiguities and provides a better representation of the water-protein interactions in oxidized cytochrome c.	Water	76-81	cytochrome c, somatic	Equus caballus	200-212
28837642-5	2017	Experiments confirm the predictions that 6-hydroxydopamine potently inhibits RecA and that PDF inhibition quantitatively tracks the water-mediated binding predictions.	Water	132-137	RAD51 recombinase	Homo sapiens	77-81
28876251-3	2017	The SRF method enables P which has already entered a body of water to be caught.	Water	61-66	serum response factor	Homo sapiens	4-7
11042041-6	2000	The identification of hydrophilic regions and detection of three long-lived water molecules settles some ambiguities and provides a better representation of the water-protein interactions in oxidized cytochrome c.	Water	161-166	cytochrome c, somatic	Equus caballus	200-212
10998552-6	2000	The double staining of mAChRs with AQP4 on two different cell-types might indicate that further interactions exist which may be important in the regulation of water and electrolyte movements in the brain.	Water	159-164	aquaporin 4	Rattus norvegicus	35-39
29116046-2	2017	Radon-water inhalation therapy for the treatment of upper and lower airway inflammatory diseases is used in many hot springs centers.	Water	6-11	alcohol dehydrogenase iron containing 1	Homo sapiens	113-116
28830187-4	2017	The energetics of the direct dissociation of water on these Lewis acid sites indicate that this process is only favored when two titanium atoms form a two-membered ring (2MR) sharing two hydroxy groups, Ti-(OH)2-Ti, which suggests that the presence of water may tune the distribution of titanium atoms within the framework of zeolite LTA.	Water	45-50	lymphotoxin alpha	Homo sapiens	334-337
28830187-4	2017	The energetics of the direct dissociation of water on these Lewis acid sites indicate that this process is only favored when two titanium atoms form a two-membered ring (2MR) sharing two hydroxy groups, Ti-(OH)2-Ti, which suggests that the presence of water may tune the distribution of titanium atoms within the framework of zeolite LTA.	Water	252-257	lymphotoxin alpha	Homo sapiens	334-337
28826498-2	2017	The importance of convective flow in the subarachnoid and paravascular spaces has long been recognized; a recently proposed "glymphatic" clearance mechanism additionally suggests that aquaporin-4 (AQP4) water channels facilitate convective transport through brain parenchyma.	Water	203-208	aquaporin 4	Mus musculus	184-195
28826498-2	2017	The importance of convective flow in the subarachnoid and paravascular spaces has long been recognized; a recently proposed "glymphatic" clearance mechanism additionally suggests that aquaporin-4 (AQP4) water channels facilitate convective transport through brain parenchyma.	Water	203-208	aquaporin 4	Mus musculus	197-201
28822043-1	2017	Water quality of the Kelani River has become a critical issue in Sri Lanka due to the high cost of maintaining drinking water standards and the market and non-market costs of deteriorating river ecosystem services.	Water	0-5	sorcin	Homo sapiens	65-68
10997928-1	2000	Aquaporin-2 (AQP2) water channel mutations cause autosomal recessive and dominant nephrogenic diabetes insipidus.	Water	19-24	aquaporin 2	Homo sapiens	0-11
28627708-3	2017	Aquaporin-4 (AQP4) water channels are the most abundant AQPs expressed in astrocytes, exerting important influences on central nervous system homeostasis.	Water	19-24	aquaporin 4	Mus musculus	0-11
10997928-1	2000	Aquaporin-2 (AQP2) water channel mutations cause autosomal recessive and dominant nephrogenic diabetes insipidus.	Water	19-24	aquaporin 2	Homo sapiens	13-17
28627708-3	2017	Aquaporin-4 (AQP4) water channels are the most abundant AQPs expressed in astrocytes, exerting important influences on central nervous system homeostasis.	Water	19-24	aquaporin 4	Mus musculus	13-17
28372175-4	2017	Besides, subsequent washing steps of the PUFA fraction with water were efficient to remove the urethanes from the final products.	Water	60-65	pumilio RNA binding family member 3	Homo sapiens	41-45
11354308-0	2000	Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells.	Water	0-5	peroxiredoxin 5	Homo sapiens	48-69
28779102-4	2017	In this study, we demonstrate that keratinocytes are responsible for the elevated production of matrix metalloproteinase-9 (MMP-9) after incubation with a water extract of RJ.	Water	155-160	matrix metallopeptidase 9	Homo sapiens	96-122
28779102-4	2017	In this study, we demonstrate that keratinocytes are responsible for the elevated production of matrix metalloproteinase-9 (MMP-9) after incubation with a water extract of RJ.	Water	155-160	matrix metallopeptidase 9	Homo sapiens	124-129
28463769-0	2017	Stable hydrogen and oxygen isotopes of tap water reveal structure of the San Francisco Bay Area"s water system and adjustments during a major drought.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
11052683-1	2000	In this work, a widely used pesticide named carbaryl, present in numerous water supplies, has been determined by the so-called heavy atom induced room-temperature phosphorescence (HAI-RTP) methodology.	Water	74-79	MORN repeat containing 4	Homo sapiens	184-187
28602073-2	2017	The system produces hydrogen at a turnover of about 240 mumol of H2 (mumol protein)-1 h-1 and 17.74 mmol of H2 (mumol protein)-1 h-1 under monochromatic green and white light, respectively, at ambient conditions, in water at neutral pH and room temperature, with methanol as a sacrificial electron donor.	Water	216-221	relaxin 2	Homo sapiens	65-89
28602073-2	2017	The system produces hydrogen at a turnover of about 240 mumol of H2 (mumol protein)-1 h-1 and 17.74 mmol of H2 (mumol protein)-1 h-1 under monochromatic green and white light, respectively, at ambient conditions, in water at neutral pH and room temperature, with methanol as a sacrificial electron donor.	Water	216-221	relaxin 2	Homo sapiens	65-85
28236528-5	2017	Overall gross Vn deposition was greater for high water content-low modulus materials (117+-4 average cell count per field) than low water content-high modulus materials (88+-6 average cell count per field).	Water	49-54	vitronectin	Homo sapiens	14-16
28236528-5	2017	Overall gross Vn deposition was greater for high water content-low modulus materials (117+-4 average cell count per field) than low water content-high modulus materials (88+-6 average cell count per field).	Water	132-137	vitronectin	Homo sapiens	14-16
28774622-2	2017	Chemical disinfection of drinking water forms DBP mixtures.	Water	34-39	D-box binding PAR bZIP transcription factor	Rattus norvegicus	46-49
11033056-6	2000	Quantitatively, however, UCN appears to be a more potent suppressor of ingestive behavior (food and water intake) and a less potent inducer of anxiogenic behavior than CRF.	Water	100-105	urocortin	Homo sapiens	25-28
28774628-2	2017	We aim to describe personal and tap water quality determinants of bottled water use in the city of Barcelona.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
10920032-7	2000	We have separated the relaxation processes due to hinge-bending motion and bound water for IgG and obtained the Fab-Fab angle of IgG as about 130 degrees by Kirkwood"s correlation parameter and the activation energy of 34 kJ/mol for hinge-bending motion.	Water	81-86	FA complementation group B	Homo sapiens	112-115
28771145-1	2017	Hundreds of waterborne disease outbreaks (WBDO) of acute gastroenteritis (AGI) due to contaminated tap water are reported in developed countries each year.	Water	12-17	nuclear RNA export factor 1	Homo sapiens	99-102
28771145-4	2017	Data for the number of AGI cases are available at the municipality level while exposure to tap water depends on drinking water networks (DWN).	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
28771145-6	2017	This study proposed to develop an algorithm which would match the most relevant grouping of municipalities with a specific DWN, in order that tap water exposure can be taken into account when investigating future disease outbreaks.	Water	146-151	nuclear RNA export factor 1	Homo sapiens	142-145
10920032-7	2000	We have separated the relaxation processes due to hinge-bending motion and bound water for IgG and obtained the Fab-Fab angle of IgG as about 130 degrees by Kirkwood"s correlation parameter and the activation energy of 34 kJ/mol for hinge-bending motion.	Water	81-86	FA complementation group B	Homo sapiens	116-119
11001488-0	2000	Routing of the aquaporin-2 water channel in health and disease.	Water	27-32	aquaporin 2	Homo sapiens	15-26
28709509-6	2017	Controlling for age, sex, years of education, and whether respondents were African American and Hispanic/Latino/a, lower perceived tap water quality was associated with lower sleep quality and shorter sleep length.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	131-134
11001488-7	2000	In contrast, in diseases with increased renal water uptake, total and apical membrane expression of aquaporin-2 is increased.	Water	46-51	aquaporin 2	Homo sapiens	100-111
10910438-1	2000	BACKGROUND: It has been suggested that urinary excretion of the vasopressin-dependent water channel of the kidney collecting duct, aquaporin-2 (AQP2), reflects renal vasopressin action and might be used clinically.	Water	86-91	aquaporin 2	Homo sapiens	131-142
28501218-0	2017	A modified fluorescein derivative with improved water-solubility for turn-on fluorescent determination of Hg2+ in aqueous and living cells.	Water	48-53	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	106-109
28501218-2	2017	In neutral water environments, ACFH presented a fluorescence-enhancement performance at lambdamax=512nm in the presence of Hg2+, which could be visualized by naked-eyes.	Water	11-16	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	123-126
28463769-9	2017	We observed delta2H and delta18O values of tap water consistent with waters originating from snowmelt from the Sierra Nevada Mountains, local precipitation, ground water, and partially evaporated reservoir sources.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
28463769-9	2017	We observed delta2H and delta18O values of tap water consistent with waters originating from snowmelt from the Sierra Nevada Mountains, local precipitation, ground water, and partially evaporated reservoir sources.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	43-46
28613440-4	2017	QM/MM calculations indicated that H3 O+ was unstable in the PcyA crystal structure, releasing a proton to an H-bond partner His88, producing H2 O and protonated His88.	Water	141-145	H3 clustered histone 15	Homo sapiens	34-38
10910438-1	2000	BACKGROUND: It has been suggested that urinary excretion of the vasopressin-dependent water channel of the kidney collecting duct, aquaporin-2 (AQP2), reflects renal vasopressin action and might be used clinically.	Water	86-91	aquaporin 2	Homo sapiens	144-148
11876876-4	2000	RESULTS: Compared with that in simple burn group, the pHi decrease could be inhibited by EEF, the portal endotoxin level, plasma TNFalpha level and renal water content were decreased by the action of EEF.	Water	154-159	glucose-6-phosphate isomerase	Rattus norvegicus	54-57
11196854-4	2000	The lack of enthalpy drive for the (OH)yOxM-O-MOx(OH)y + H2O--&gt;2MOx-1(OH)y+2 reaction was taken to suggest that entropy increase and the formation of mononuclear water complexe, would be decisive factors for the dissociation.	Water	165-170	monooxygenase DBH like 1	Homo sapiens	46-49
28432888-5	2017	In addition, the microgels were also shown moderate adsorption capacity for Cr (VI) and As (V) from other water sources; tap water with 115.18 mg/g and 82.86 mg/g, sea water with 64.24 mg/g and 46.88 mg/g and creek water with 73.52 mg/g and 59.33 mg/g, respectively.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
28432888-5	2017	In addition, the microgels were also shown moderate adsorption capacity for Cr (VI) and As (V) from other water sources; tap water with 115.18 mg/g and 82.86 mg/g, sea water with 64.24 mg/g and 46.88 mg/g and creek water with 73.52 mg/g and 59.33 mg/g, respectively.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
28432888-5	2017	In addition, the microgels were also shown moderate adsorption capacity for Cr (VI) and As (V) from other water sources; tap water with 115.18 mg/g and 82.86 mg/g, sea water with 64.24 mg/g and 46.88 mg/g and creek water with 73.52 mg/g and 59.33 mg/g, respectively.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
10937843-0	2000	Increased expression and shuttling of aquaporin-2 water channels in the kidney in DOCA-salt hypertensive rats.	Water	50-55	aquaporin 2	Rattus norvegicus	38-49
28740499-7	2017	Gene-gene and gene-metabolite network analyses showed that water deficit-responsive transcription factors such as bZIPs, AP2/ERFs, MYBs, and NACs are implicated in the regulation of stress-responsive metabolites.	Water	59-64	transcription factor APETALA2	Vitis vinifera	121-124
10889172-2	2000	Recent studies have indicated that Hsp60 expression, induced by exposure to water immersion stress, protects against pancreatitis induced by administration of supramaximal doses of cerulein in rats.	Water	76-81	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	35-40
28529020-3	2017	The patient may have been exposed to waterborne pathogens despite terminal water filtration due to a technical device to release residual tap water from the hose after showering.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	138-141
28529020-3	2017	The patient may have been exposed to waterborne pathogens despite terminal water filtration due to a technical device to release residual tap water from the hose after showering.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	138-141
10889172-6	2000	RESULTS: The results confirm that prior induction of Hsp60 expression by water-immersion stress significantly ameliorates the severity of cerulein-induced pancreatitis as judged by the markedly reduced degree of hyperamylasemia, pancreatic edema, and acinar cell necrosis.	Water	73-78	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	53-58
10889172-7	2000	Water immersion also prevents the subcellular redistribution of cathepsin B from a lysosome-enriched fraction to a heavier, zymogen granule-enriched fraction that is known to occur in this model of pancreatitis.	Water	0-5	cathepsin B	Rattus norvegicus	64-75
28242751-1	2017	The mucoprotein uromodulin is the most abundant protein in mammalian urine and has important roles in ion transport, maintenance of water and electrolyte balance, and clearance of bacteria from the urinary tract.	Water	132-137	uromodulin	Homo sapiens	16-26
10889172-10	2000	CONCLUSIONS: Water-immersion stress induces Hsp60 expression, ameliorates cerulein-induced pancreatitis, and prevents intra-acinar cell activation of trypsinogen.	Water	13-18	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	44-49
11008690-0	2000	[Microbiological processes at the interface of aerobic and anaerobic waters in the deep-water zone of the Black Sea].	Water	69-74	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	112-115
28343244-3	2017	The probe showed high selectivity and sensitivity to Hg2+ over other metal ions such as Pb2+, Na+, K+, Cd2+, Cr3+, Zn2+, Cu2+, Ni2+, Ca2+, Fe3+, Fe2+, Co2+, Mn2+ and Mg2+ in MeCN/H2O (15/85, v/v).	Water	179-182	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	53-56
11008690-1	2000	Chemical and key microbiological processes (assimilation of carbon dioxide, oxidation and formation of methane, and sulfate reduction) occurring at the boundary between the aerobic-anaerobic interface in the deep-water zone of the Black Sea were investigated.	Water	213-218	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	237-240
10869574-2	2000	CFTR also enhances osmotic water permeability when activated by cAMP.	Water	27-32	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	0-4
28429174-0	2017	A Unique Sensitive and Highly Selective Fluorescent Naphthodiaza-Crown Macrocyclic Ligand Chemosensor for Hg2+ in Water.	Water	114-119	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	106-109
28429174-2	2017	The observed ultra-low limit of detection (LOD) for Hg2+ by L was determined as low as 1.0 x 10-11 M in water.	Water	104-109	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	52-55
10926225-3	2000	4H2O or Ni(ClO4)2.6H2O to give the multinuclear nickel(II) complexes [Ni(H-1-Imin)(OAc)]2 (2) (which contains a coordinated Schiff base obtained by reation of the primary amine with the acetone solvent) and [Ni3(H3-1)(H2-1)2]-ClO4.H2O.3 MeCN (3), respectively.	Water	1-4	H3 clustered histone 3	Homo sapiens	212-216
28318025-17	2017	MCH increased expression of genes regulating sodium (SCNN1-B, ATP1-A1, ATP1-B1) and water (AQP-4) movement in the fetal lung.	Water	84-89	aquaporin 4	Homo sapiens	91-96
10836977-1	2000	Carbonic anhydrase (CA) IV is a membrane-bound enzyme that catalyzes the dehydration of carbonic acid to CO(2) and water.	Water	115-120	carbonic anhydrase 4	Oryctolagus cuniculus	0-26
28390076-6	2017	The osmotic water permeability of mesophyll protoplasts of AtHXK1-expressing plants and the leaf hydraulic conductance of those plants were significantly reduced, in line with the decreased expression of PIP-AQPs.	Water	12-17	hexokinase 1	Arabidopsis thaliana	59-65
28390076-9	2017	The production of sugars entails a significant loss of water and these results suggest that sugars and AtHXK1 affect the expression of AQP genes and reduce leaf water conductance, to coordinate sugar levels with the loss of water through transpiration.	Water	55-60	hexokinase 1	Arabidopsis thaliana	103-109
10938462-1	2000	We have examined the release of H(2)O(2) from PAF or TNFalpha-stimulated human eosinophils on fibronectin (FN)-coated polystyrene plates.	Water	32-37	PCNA clamp associated factor	Homo sapiens	46-49
28390076-9	2017	The production of sugars entails a significant loss of water and these results suggest that sugars and AtHXK1 affect the expression of AQP genes and reduce leaf water conductance, to coordinate sugar levels with the loss of water through transpiration.	Water	161-166	hexokinase 1	Arabidopsis thaliana	103-109
28706505-6	2017	CONCLUSION: MECs are connected via tight junctions and gap junctions, and they possess AQP4 water channels.	Water	92-97	aquaporin 4	Homo sapiens	87-91
28506803-1	2017	We report water-in-oil microemulsion mediated synthesis of PEG1 coated Gd2O3 NPs2 loaded with fluorescent anti-cancer drug dox3 for synchronous drug delivery, optical and MR4 imaging applications.	Water	10-15	mesoderm specific transcript	Homo sapiens	59-63
10878500-5	2000	Furthermore, we have previously shown that chronic DOCA administration results in an increase in mRNA levels of the endogenous opiate enkephalin in male rats given 24-hour access to tap water and 2% NaCl (two-bottle choice).	Water	186-191	proenkephalin	Rattus norvegicus	134-144
28471069-3	2017	Herein, Born-Oppenheimer molecular dynamics (BOMD) simulations examine the dynamic behavior of syn- and anti-CH3 CHOO at the air-water interface.	Water	129-134	synemin	Homo sapiens	95-98
28471069-4	2017	They show that unlike the simplest Criegee intermediate (CH2 OO), both syn- and anti-CH3 CHOO remain inert towards reaction with water.	Water	129-134	synemin	Homo sapiens	71-74
12526492-1	2000	The reaction of [Ru(bpy)2L(H2O)]2+ (bpy = 2,2"-bipyridine, L = imidazole, water) with reduced horse heart cytochrome c results in coordination of [RuII(bpy)2L] at the His 33 and His 26 sites.	Water	74-79	cytochrome c, somatic	Equus caballus	106-118
28471069-6	2017	The simulation of the larger Criegee intermediates, (CH3 )2 COO, syn- and anti-CH2 C(CH3 )C(H)OO on the water droplet surface suggests that strongly hydrophobic substituents determine the reactivity of Criegee intermediates at the air-water interface.	Water	104-109	synemin	Homo sapiens	65-68
28471069-6	2017	The simulation of the larger Criegee intermediates, (CH3 )2 COO, syn- and anti-CH2 C(CH3 )C(H)OO on the water droplet surface suggests that strongly hydrophobic substituents determine the reactivity of Criegee intermediates at the air-water interface.	Water	235-240	synemin	Homo sapiens	65-68
10801354-6	2000	Subsequently, we superposed the active-site of the RNase LE with that of RNase Rh and found that (1) His39, Trp42, His92, Glu93, Lys96, and His97 of RNase LE coincided exactly with His46, Trp49, His104, Glu105, Lys108, and His109, respectively, of RNase Rh, and (2) two conserved water molecules were found at the putative P(1) sites of both enzymes.	Water	280-285	ribonuclease T2	Solanum lycopersicum	51-59
10801354-6	2000	Subsequently, we superposed the active-site of the RNase LE with that of RNase Rh and found that (1) His39, Trp42, His92, Glu93, Lys96, and His97 of RNase LE coincided exactly with His46, Trp49, His104, Glu105, Lys108, and His109, respectively, of RNase Rh, and (2) two conserved water molecules were found at the putative P(1) sites of both enzymes.	Water	280-285	ribonuclease T2	Solanum lycopersicum	149-157
10794719-3	2000	Here we study the membrane-induced conformational change of Apo H by CD spectroscopy with two different model systems: anionic-phospholipid-containing liposomes [such as 1, 2-dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG) and cardiolipin], and the water/methanol mixtures at moderately low pH, which mimic the micro-physicochemical environment near the membrane surface.	Water	249-254	apolipoprotein H	Homo sapiens	60-65
10794719-6	2000	The similar conformation change in Apo H can be induced by treatment with an appropriate mixture of water/methanol.	Water	100-105	apolipoprotein H	Homo sapiens	35-40
10807589-1	2000	This study investigated the ability of the renal Na(+)-dicarboxylate cotransporter, NaDC-1, to transport water.	Water	105-110	solute carrier family 13 member 2	Oryctolagus cuniculus	84-90
10807589-3	2000	In the absence of substrates, oocytes expressing NaDC-1 showed an increase in osmotic water permeability, which was directly correlated with the expression level of NaDC-1.	Water	86-91	solute carrier family 13 member 2	Oryctolagus cuniculus	49-55
10904878-5	2000	The expression of c-myc, Ha-ras and p53 gene was followed in CBA/Ca sensitive inbred mice drinking tap water or deuterium-depleted water (DDW) after induction.	Water	131-136	transformation related protein 53, pseudogene	Mus musculus	36-39
10867111-3	2000	These findings led to a clinical development program exploring the antidepressive potential of R121919, a water-soluble pyrrolopyrimidine that binds with high affinity to human CRH(1) receptors and is well absorbed in humans.	Water	106-111	corticotropin releasing hormone	Homo sapiens	177-180
10738199-1	2000	Biological self-assembly process of tropoelastin in an extracellular space, viewed as a key step of the elastogenesis, can be mimicked by the temperature-dependent coacervation of the elastin-related polypeptide-water system.	Water	212-217	elastin	Bos taurus	36-48
10751213-9	2000	The differences between rabbits and rats in the distribution patterns of ENaC and AQP2 may explain functional differences in renal salt and water handling between these species.	Water	140-145	aquaporin 2	Rattus norvegicus	82-86
18494583-0	2000	Imidazoline Receptor Contributes to Ion and Water Transport across the Intestine of the Eel Acclimated to Sea Water.	Water	44-49	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	106-109
10727222-4	2000	Whereas in the presence of H(2)O the electrogenic phase developed concomitantly with cytochrome b reduction, it lagged for a few hundreds of microseconds after cytochrome b reduction in the presence of D(2)O.	Water	27-32	cytochrome b	Chlamydomonas reinhardtii	85-97
10688911-2	2000	We now show that the C-terminal Cys(497)-SH/SeCys(498)-Se(-) of NADPH-reduced enzyme, after anaerobic dialysis, was converted to a thioselenide on incubation with excess oxidized Trx (TrxS(2)) or H(2)O(2).	Water	196-201	thioredoxin	Homo sapiens	179-182
10602075-4	2000	The adsorption curve increased rapidly and then flattened out at 72 h; 90% of the maximum was already reached at 24 h; and 20% of the adsorbed IGF-I was released in water within 4 days.	Water	165-170	insulin-like growth factor I	Oryctolagus cuniculus	143-148
10725169-0	2000	Enzymatic hydrolysis, grease permeation, and water barrier properties of zein isolate coated paper.	Water	45-50	zein	Zea mays	73-77
10737728-4	2000	Glycoprotein with the same domain structure of hemopexin has been proposed to be an important carrier protein that forms the tumor-localizing activity of water-soluble porphyrin.	Water	154-159	hemopexin	Mus musculus	47-56
11272579-1	2000	This study consists of two parts: The first part comprised an experimental determination of the kinetic parameters for the exchange of water between UO2(H2O)5(2+) and bulk water, including an ab initio study at the SCF and MP2 levels of the geometry of UO2(H2O)5(2+), UO2(H2O)4(2+), and UO2(H2O)6(2+) and the thermodynamics of their reactions with water.	Water	135-140	tryptase pseudogene 1	Homo sapiens	223-226
10675514-8	2000	Xenopus oocytes injected with the mRNA of the dog AQP1 exhibited high water permeability in a hyposmotic medium.	Water	70-75	aquaporin-1	Canis lupus familiaris	50-54
28582770-1	2017	The purpose of the current study was to explore the effects of the water extracts of Epimedii Folium and Curculiginis Rhizoma (EX) on Abeta-induced Alzheimer"s disease.	Water	67-72	amyloid beta precursor protein	Rattus norvegicus	134-139
10675514-9	2000	Thus, dog AQP1 performs water transport the same as in the other species.	Water	24-29	aquaporin-1	Canis lupus familiaris	10-14
11017513-4	2000	We argue that the repulsion is due to the water structuring, enhanced by the accumulation of hydrophilic counterions around the apoferritin molecules, giving rise to so-called hydration forces.	Water	42-47	ferritin heavy chain 1	Homo sapiens	128-139
28488787-0	2017	Nitrotoga is selected over Nitrospira in newly assembled biofilm communities from a tap water source community at increased nitrite loading.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
30505209-2	2017	Pilot scale experiments were performed in a distribution system simulator by injecting arsenic and measuring both adsorption onto iron pipe material and the oxidation of arsenite by hypochlorite in tap water to form arsenate.	Water	202-207	nuclear RNA export factor 1	Homo sapiens	198-201
10651644-11	2000	Analysis of their absorption spectra under various pH conditions reveals pK(a) values of 6.5 and 5.6 for the metal-bound water in E133A and E133D Co-PDF, respectively, suggesting that the metal ion alone is capable of ionizing the water molecule to generate the catalytic nucleophile, a metal-bound hydroxide.	Water	121-126	peptide deformylase, mitochondrial	Homo sapiens	149-152
10651644-11	2000	Analysis of their absorption spectra under various pH conditions reveals pK(a) values of 6.5 and 5.6 for the metal-bound water in E133A and E133D Co-PDF, respectively, suggesting that the metal ion alone is capable of ionizing the water molecule to generate the catalytic nucleophile, a metal-bound hydroxide.	Water	231-236	peptide deformylase, mitochondrial	Homo sapiens	149-152
10721484-6	2000	The sedimentation coefficients of MS-2 shifted from 80S to 58S, 48S, 37S, 32S, and 18S as inactivation proceeded in groundwater and distilled water controls.	Water	122-127	MS2	Homo sapiens	34-38
10644652-6	2000	Several of the mammalian aquaporins (e.g., AQP1, AQP2, AQP4, and AQP5) appear to be highly selective for the passage of water, whereas others (recently termed aquaglyceroporins) also transport glycerol (e.g., AQP3 and AQP8) and even larger solutes (AQP9).	Water	120-125	aquaporin 2	Homo sapiens	49-53
28638927-1	2017	Aquaporin-4 (AQP-4) is the predominant water channel in the central nervous system (CNS) and primarily expressed in astrocytes.	Water	39-44	aquaporin 4	Homo sapiens	0-11
28638927-1	2017	Aquaporin-4 (AQP-4) is the predominant water channel in the central nervous system (CNS) and primarily expressed in astrocytes.	Water	39-44	aquaporin 4	Homo sapiens	13-18
10644652-6	2000	Several of the mammalian aquaporins (e.g., AQP1, AQP2, AQP4, and AQP5) appear to be highly selective for the passage of water, whereas others (recently termed aquaglyceroporins) also transport glycerol (e.g., AQP3 and AQP8) and even larger solutes (AQP9).	Water	120-125	aquaporin 5	Homo sapiens	65-69
10644950-5	2000	We show that the decrease of solution water activity, due to the addition of sucrose, glycerol, ethylene glycol, and betaine, favors drug binding to the strong binding sites on DNA by increasing both the apparent binding affinity delta G, and the number of DNA base pairs apparently occupied by the bound drug nbp/actD.	Water	38-43	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	310-313
28557430-0	2017	Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.	Water	20-25	insulin like growth factor 1 receptor	Homo sapiens	78-115
28557430-6	2017	Screening molecular targets of water-soluble 3"-oxime ethers revealed 6ha as preferential inhibitor of insulin-like growth factor 1 receptor (IGF-1R) in a panel of 22 protein kinases and in cells.	Water	31-36	insulin like growth factor 1 receptor	Homo sapiens	103-140
28557430-6	2017	Screening molecular targets of water-soluble 3"-oxime ethers revealed 6ha as preferential inhibitor of insulin-like growth factor 1 receptor (IGF-1R) in a panel of 22 protein kinases and in cells.	Water	31-36	insulin like growth factor 1 receptor	Homo sapiens	142-148
10644880-1	2000	BACKGROUND: Stimulation of arginine vasopressin results in an immediate redistribution of water channels (aquaporin 2; AQP2) in the apical membrane of the collecting ducts, leading to water reabsorption.	Water	90-95	aquaporin 2	Rattus norvegicus	106-117
28570806-2	2017	An improvement of the ReaxFF reactive water force field on the basis of our first-generation water force field (water-2010) is presented to describe the proton transfer (PT) mechanisms of H3O+ and OH- in water.	Water	38-43	H3 clustered histone 15	Homo sapiens	188-199
10644880-1	2000	BACKGROUND: Stimulation of arginine vasopressin results in an immediate redistribution of water channels (aquaporin 2; AQP2) in the apical membrane of the collecting ducts, leading to water reabsorption.	Water	90-95	aquaporin 2	Rattus norvegicus	119-123
10644880-2	2000	Water restriction for &gt;/=24 h increases AQP2 proteins in the whole collecting duct which is highest in the inner medulla of the kidney, indicating that dehydration enhances synthesis of this protein.	Water	0-5	aquaporin 2	Rattus norvegicus	43-47
27836598-6	2017	Moreover, the application for detecting tap water samples further demonstrates that this AuNP-based assay can be an excellent method used for sensing mercury at very low content in the environment.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
11196807-3	2000	Crystals of trenphen.H2O.CH3CN, 1, are monoclinic, space group P2(1)/n, a = 14.9923(8) A, b = 17.4451(10) A, c = 17.1880(10) A, beta = 114.8290(10) degrees, V = 4079.9(4) A3, Z = 4.	Water	21-24	H3 histone pseudogene 16	Homo sapiens	63-68
28619801-1	2017	Strain Sph1(2015), Isolated from a Fouled Membrane Filter Used To Produce Drinking Water.	Water	83-88	ankyrin 1	Homo sapiens	7-11
10794494-1	2000	Aquaporin-1(AQP1) and AQP2 are members of the aquaporin family of cell membrane water channel transport proteins and have been implicated in the regulation of renal water excretion.	Water	80-85	aquaporin 2	Mus musculus	22-26
28619801-3	2017	strain Sph1(2015), isolated from a fouled reverse osmosis membrane used for the production of high-quality drinking water.	Water	116-121	ankyrin 1	Homo sapiens	7-11
10939276-1	2000	Kynurenine-3-monooxygenase (KM), the third enzyme in the kynurenine (KYN) pathway from tryptophan to quinolinic acid (QA), is a monooxygenase requiring oxygen, NADPH and FAD for the catalytic oxidation of L-kynurenine to 3-hydroxykynurenine and water.	Water	245-250	kynurenine 3-monooxygenase	Homo sapiens	0-26
28371520-5	2017	We demonstrate that these photoanodes in tandem with a CH3 NH3 PbI3 perovskite solar cell achieves overall unassisted water splitting with an STH conversion efficiency of 3.4 %, constituting a new benchmark for hematite-based tandem systems.	Water	118-123	saitohin	Homo sapiens	142-145
10916423-4	2000	The water channels aquaporin-3 (AQP3) and aquaporin-4 (AQP4), which are constitutively present in the basolateral membrane, allow the exit of water from the cell into the hypertonic interstitium.	Water	4-9	aquaporin 3 (Gill blood group)	Homo sapiens	19-30
28595392-1	2017	Time-resolved resonance-enhanced Stokes and anti-Stokes Raman spectra of the thiocyanate dimer radical anion, (SCN)2 -, prepared by pulse radiolysis in water, have been obtained and interpreted in conjunction with theoretical calculations to provide detailed information on the molecular geometry and bond properties of the species.	Water	152-157	growth factor independent 1 transcriptional repressor	Homo sapiens	111-116
28595392-10	2017	The Stokes and anti-Stokes Raman frequencies were found to be identical within the experimental uncertainty, suggesting that the frequency difference between the thermally relaxed and spontaneously created vibrational states of (SCN)2 - in water is too small to be observable.	Water	240-245	growth factor independent 1 transcriptional repressor	Homo sapiens	229-234
10916423-4	2000	The water channels aquaporin-3 (AQP3) and aquaporin-4 (AQP4), which are constitutively present in the basolateral membrane, allow the exit of water from the cell into the hypertonic interstitium.	Water	4-9	aquaporin 3 (Gill blood group)	Homo sapiens	32-36
28492305-6	2017	We produced singlet oxygen at a point near the oil-water interface of a given PUFA droplet in a spatially localized two-photon photosensitized process.	Water	51-56	pumilio RNA binding family member 3	Homo sapiens	78-82
10916423-4	2000	The water channels aquaporin-3 (AQP3) and aquaporin-4 (AQP4), which are constitutively present in the basolateral membrane, allow the exit of water from the cell into the hypertonic interstitium.	Water	142-147	aquaporin 3 (Gill blood group)	Homo sapiens	19-30
10916423-4	2000	The water channels aquaporin-3 (AQP3) and aquaporin-4 (AQP4), which are constitutively present in the basolateral membrane, allow the exit of water from the cell into the hypertonic interstitium.	Water	142-147	aquaporin 3 (Gill blood group)	Homo sapiens	32-36
10574954-7	1999	The mutants and wild-type AQP2 were equally susceptible to digestion by trypsin, thermolysin, and proteinase K. Stopped-flow light scattering measurements indicated that T126M AQP2 at the ER was fully functional as a water channel.	Water	217-222	aquaporin 2	Homo sapiens	176-180
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Water	107-112	solute carrier family 51 subunit alpha	Rattus norvegicus	173-179
10639821-10	1999	Congenital NDI with an autosomal recessive inheritance has mutations of Aquaporin-2 gene, a vasopressin-sensitive water channel in the renal inner medullary collecting duct (IMCD).	Water	114-119	aquaporin 2	Homo sapiens	72-83
28284958-2	2017	This study reports a complete survey of the fluoridated tap water taken from 100 water consumption points in Tunisia.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
10561494-2	1999	Three genes out of 89 clones, identified as fibronectin, p105 coactivator and ECA39, showed increased expression after treatment with H(2)O(2).	Water	134-139	fibronectin 1	Rattus norvegicus	44-55
28317216-1	2017	Aquaporin-4 (AQP4), the predominant water channel in the brain, is expressed in astrocytes and ependymal cells.	Water	36-41	aquaporin 4	Mus musculus	0-11
28317216-1	2017	Aquaporin-4 (AQP4), the predominant water channel in the brain, is expressed in astrocytes and ependymal cells.	Water	36-41	aquaporin 4	Mus musculus	13-17
28317216-6	2017	In mouse we found that AQP4 water channels were prominently clustered around vessels, being 5 to 10-fold more abundant in astrocytic endfoot membranes facing the capillary endothelium than in parenchymal astrocytic membranes.	Water	28-33	aquaporin 4	Mus musculus	23-27
10561494-2	1999	Three genes out of 89 clones, identified as fibronectin, p105 coactivator and ECA39, showed increased expression after treatment with H(2)O(2).	Water	134-139	staphylococcal nuclease and tudor domain containing 1	Rattus norvegicus	57-73
10574788-0	1999	The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins.	Water	88-93	H3 histone pseudogene 16	Homo sapiens	28-31
27620834-2	2017	When expressed in Xenopus laevis oocytes, AtPIP2;1 increased water permeability and induced a non-selective cation conductance mainly associated with Na+ .	Water	61-66	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	42-50
27620834-3	2017	A mutation in the water pore, G103W, prevented both the ionic conductance and water permeability of PIP2;1.	Water	18-23	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	100-106
10574788-6	1999	The structure of this complex differs from that of p21(ras)-GppNHp (determined at 277K) with respect to the degree of order and conformation of the catalytic loop (loop 4 of the switch II region) and the positioning of water molecules around the gamma-phosphate group.	Water	219-224	H3 histone pseudogene 16	Homo sapiens	51-54
27620834-3	2017	A mutation in the water pore, G103W, prevented both the ionic conductance and water permeability of PIP2;1.	Water	78-83	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	100-106
27620834-4	2017	Co-expression of AtPIP2;1 with AtPIP1;2 increased water permeability but abolished the ionic conductance.	Water	50-55	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	17-23
10555969-1	1999	The role of the zinc site in the N-terminal fragment of human Sonic hedgehog (ShhN) was explored by comparing the biophysical and functional properties of wild-type ShhN with those of mutants in which the zinc-coordinating residues H140, D147, and H182, or E176 which interacts with the metal ion via a bridging water molecule, were mutated to alanine.	Water	312-317	sonic hedgehog signaling molecule	Homo sapiens	62-76
27620834-5	2017	AtPIP2;2 (93% identical to AtPIP2;1) similarly increased water permeability but not ionic conductance.	Water	57-62	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	27-35
27620834-9	2017	Establishing whether AtPIP2;1 has dual ion and water permeability in planta will be important in understanding the roles of this aquaporin and if AtPIP2;1 is a candidate for a previously reported NSCC responsible for Ca2+ and pH sensitive Na+ entry into roots.	Water	47-52	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	21-29
10647010-4	1999	When expressed in Xenopus laevis oocytes, AQP6 exhibits low basal water permeability; however, when treated with the known water channel inhibitor, Hg2+, the water permeability of AQP6 oocytes rapidly rises up to tenfold and is accompanied by ion conductance.	Water	66-71	aquaporin 6	Homo sapiens	42-46
28237470-3	2017	Land use of the watershed is mainly agricultural leading to groundwater nitrate concentrations &gt;50mgL-1 and a need for water treatment prior to utilization as drinking water.	Water	16-21	LLGL scribble cell polarity complex component 1	Homo sapiens	101-106
28713508-0	2017	Presence and seasonal variation of trihalomethanes (THMs) levels in drinking tap water in Mostaganem Province in northwest Algeria.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
28713508-4	2017	AIM: The aim of this study was to determine the presence of THMs in the drinking tap water of Mostaganem Province (Algeria) in order to assess the seasonal variation in trihalomethane levels in tap water and to identify the season of high risk to the consumer.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
10647010-4	1999	When expressed in Xenopus laevis oocytes, AQP6 exhibits low basal water permeability; however, when treated with the known water channel inhibitor, Hg2+, the water permeability of AQP6 oocytes rapidly rises up to tenfold and is accompanied by ion conductance.	Water	66-71	aquaporin 6	Homo sapiens	180-184
10647010-4	1999	When expressed in Xenopus laevis oocytes, AQP6 exhibits low basal water permeability; however, when treated with the known water channel inhibitor, Hg2+, the water permeability of AQP6 oocytes rapidly rises up to tenfold and is accompanied by ion conductance.	Water	123-128	aquaporin 6	Homo sapiens	42-46
10647010-4	1999	When expressed in Xenopus laevis oocytes, AQP6 exhibits low basal water permeability; however, when treated with the known water channel inhibitor, Hg2+, the water permeability of AQP6 oocytes rapidly rises up to tenfold and is accompanied by ion conductance.	Water	123-128	aquaporin 6	Homo sapiens	180-184
28675971-8	2017	Benzyl-isothiocyanate addition of 75 mgl-1 before starting the washing process gave rise to a complete removal of total bacteria and Salmonella in the wash water after 24 h before starting the second cycle.	Water	156-161	LLGL scribble cell polarity complex component 1	Homo sapiens	37-42
10545357-2	1999	Using the substituted cysteine accessibility method, we investigated whether residues in the alpha(1)M3 membrane-spanning segment are water-accessible.	Water	134-139	adrenoceptor alpha 1D	Homo sapiens	93-103
28516821-0	2017	Pseudomonas aeruginosa Outbreak in a Neonatal Intensive Care Unit Attributed to Hospital Tap Water.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
28525992-8	2017	Plain drinking water provided 258 g/d (241 g/d for children aged 4-8 years; 274 g/d for 9-13 years), mostly (83.8%) from tap.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	121-124
28525992-10	2017	Tap water consumption increased with income and was highest in the South of England.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
28266184-1	2017	Anionic and neutral fullerene derivatives were dissolved in water by using beta-(1,3-1,6)-d-glucan (beta-1,3-glucan) as a solubilizing agent.	Water	60-65	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	100-108
31966617-0	2017	Irisin attenuates H2O2-induced apoptosis in cardiomyocytes via microRNA-19b/AKT/mTOR signaling pathway.	Water	18-22	mechanistic target of rapamycin kinase	Rattus norvegicus	80-84
10690135-2	1999	Aquaporin-2 (AQP2) is an arginine vasopressin (AVP)-regulated water channel protein localized to the apical region of renal collecting duct cells and is involved in the regulation of water permeability.	Water	62-67	aquaporin 2	Homo sapiens	0-11
31966617-13	2017	Further study demonstrated that Irisin-regulated miR-19b could reactivate the AKT/mTOR signaling pathway blocked by H2O2 in H9c2 cells.	Water	116-120	mechanistic target of rapamycin kinase	Rattus norvegicus	82-86
10690135-2	1999	Aquaporin-2 (AQP2) is an arginine vasopressin (AVP)-regulated water channel protein localized to the apical region of renal collecting duct cells and is involved in the regulation of water permeability.	Water	62-67	aquaporin 2	Homo sapiens	13-17
28516898-0	2017	Structural and magnetic properties of spin-1/2 dimer compound Cu2(IPA)2(DMF)(H2O) with a large spin gap.	Water	77-80	spindlin 1	Homo sapiens	38-46
28088348-6	2017	Acute KuA postconditioning not only significantly reduced cerebral infarct volume, brain water content and improved neurological deficit scores, but also decreased the number of TUNEL-positive cells.	Water	89-94	plasmanylethanolamine desaturase 1	Rattus norvegicus	6-9
10690135-2	1999	Aquaporin-2 (AQP2) is an arginine vasopressin (AVP)-regulated water channel protein localized to the apical region of renal collecting duct cells and is involved in the regulation of water permeability.	Water	183-188	aquaporin 2	Homo sapiens	0-11
10690135-2	1999	Aquaporin-2 (AQP2) is an arginine vasopressin (AVP)-regulated water channel protein localized to the apical region of renal collecting duct cells and is involved in the regulation of water permeability.	Water	183-188	aquaporin 2	Homo sapiens	13-17
10534323-2	1999	A water-soluble phosphoramidate prodrug (L-758,298, compound I) of the potent and selective human Substance P receptor antagonist L-754, 030 (compound II) is under development as an i.v.	Water	2-7	tachykinin receptor 1	Homo sapiens	98-118
28725129-2	2017	METHODS: Five different samples of tap water collected from each of the four emirates of UAE: Ajman, Sharjah, Abu Dhabi and Dubai; twenty-two brands of bottled water and fifteen brands of popular cold beverages, purchased from different supermarkets in U.A.E were tested using ion selective electrode method and the fluoride concentration was determined.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
28725129-3	2017	RESULTS: The mean fluoride content of tap water samples was 0.14 mg F/L with a range of 0.04-0.3 mg F/L; with Ajman tap water samples showing the highest mean fluoride content of 0.3 mg F/L.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
10525117-3	1999	This investigation focused on the possibility that this increase in free water clearance following administration of an alpha(2)-adrenoceptor agonist was associated with a reduction in medullary AQP-2 expression.	Water	73-78	aquaporin 2	Rattus norvegicus	195-200
28546328-7	2017	RESULTS: Genetic deletion of the miR-15a/16-1 cluster or intravenous delivery of miR-15a/16-1 antagomir significantly reduced cerebral infarct size, decreased brain water content, and improved neurological outcomes in stroke mice.	Water	165-170	microRNA 15a	Mus musculus	33-40
28546328-7	2017	RESULTS: Genetic deletion of the miR-15a/16-1 cluster or intravenous delivery of miR-15a/16-1 antagomir significantly reduced cerebral infarct size, decreased brain water content, and improved neurological outcomes in stroke mice.	Water	165-170	microRNA 15a	Mus musculus	81-88
10525117-5	1999	The increase in free water clearance with clonidine administration was associated with a reduction in whole kidney AQP-2 mRNA levels (282+/-25 versus 216+/-11 A units, p&lt;.05).	Water	21-26	aquaporin 2	Rattus norvegicus	115-120
10525117-6	1999	This decrease in water reabsorption was associated with a redistribution of AQP-2 away from the luminal membrane of the medullary collecting duct to the cytosol.	Water	17-22	aquaporin 2	Rattus norvegicus	76-81
28427649-2	2017	In this research, humic acid was used as a source of dissolved organic carbon (DOC) in drinking water (up to 3mgL-1).	Water	96-101	LLGL scribble cell polarity complex component 1	Homo sapiens	110-115
10549572-0	1999	Stability and cytotoxicity of Fab-ricin A immunotoxins prepared with water soluble long chain heterobifunctional crosslinking agents.	Water	69-74	FA complementation group B	Homo sapiens	30-33
28558469-5	2017	This report characterizes a dinuclear copper water oxidation catalyst, {[(L)Cu(II)]2-(mu-OH)2}(OTf)2 (L = Me2TMPA = bis((6-methyl-2-pyridyl)methyl)(2-pyridylmethyl)amine) in which water oxidation proceeds with high Faradaic efficiency (&gt;90%) and moderate rates (33 s-1 at ~1 V overpotential, pH 12.5).	Water	45-50	POU class 2 homeobox 2	Homo sapiens	95-100
10549572-4	1999	The conjugation yield of the Fab-RTA immunotoxin from the water soluble long chain crosslinking agents, S-LC-SMPT and S-LC-SPDP, were comparable.	Water	58-63	FA complementation group B	Homo sapiens	29-32
28370430-6	2017	The chelation process of 16 is monitored by NMR spectroscopy and the subsequent release of Ga3+ by a competitive metal chelator exemplifies the reversible oligomerization of peptide epitopes by metal chelation, bearing the opportunity to synthesize protein-sized aggregates on the basis of reversible chemistry in water.	Water	314-319	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	91-94
28570806-2	2017	An improvement of the ReaxFF reactive water force field on the basis of our first-generation water force field (water-2010) is presented to describe the proton transfer (PT) mechanisms of H3O+ and OH- in water.	Water	93-98	H3 clustered histone 15	Homo sapiens	188-199
10549572-4	1999	The conjugation yield of the Fab-RTA immunotoxin from the water soluble long chain crosslinking agents, S-LC-SMPT and S-LC-SPDP, were comparable.	Water	58-63	MAS related GPR family member F	Homo sapiens	33-36
10576413-1	1999	Microsomal epoxide hydrolase catalyses the hydrolysis of epoxides to water-soluble trans-dihydrodiols.	Water	69-74	epoxide hydrolase 1	Homo sapiens	0-28
28638135-2	2017	Aqy1, which is a water transporting aquaporin of the yeast Pichia pastoris, is suggested to be gated by chemo-mechanical stimuli as a protective regulatory-response against rapid freezing.	Water	17-22	Aqy1p	Saccharomyces cerevisiae S288C	0-4
10505693-1	1999	Aquaporin-2 (AQP-2), a water channel located on the apical membrane of collecting duct cells, regulates water reabsorption under the control of vasopressin (AVP).	Water	23-28	aquaporin 2	Homo sapiens	0-11
28605186-3	2017	Here, we report the development of oil-in-water-in-oil (O1/W/O2) double nanoemulsions via a two-step high-energy method and their use as templates for complex nanogels comprised of inner oil droplets encapsulated within a hydrogel matrix.	Water	42-47	immunoglobulin kappa variable 2D-40	Homo sapiens	56-63
28214744-4	2017	In distilled water and phosphate buffered aqueous solution at neutral pH, 1 exhibited a selective Off-On response to a soft metal ion, Hg2+ among test metal ions by 100-fold enhancement of the emission at 470nm.	Water	13-18	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	135-138
28214744-6	2017	The detection limit of 0.46 ppb for Hg2+ and 2.26 ppb for Al3+ in each condition was lower than the maximum allowable level of the metal ions in drinking water by EPA.	Water	154-159	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	36-39
10505693-1	1999	Aquaporin-2 (AQP-2), a water channel located on the apical membrane of collecting duct cells, regulates water reabsorption under the control of vasopressin (AVP).	Water	23-28	aquaporin 2	Homo sapiens	13-18
10505693-1	1999	Aquaporin-2 (AQP-2), a water channel located on the apical membrane of collecting duct cells, regulates water reabsorption under the control of vasopressin (AVP).	Water	104-109	aquaporin 2	Homo sapiens	0-11
10505693-1	1999	Aquaporin-2 (AQP-2), a water channel located on the apical membrane of collecting duct cells, regulates water reabsorption under the control of vasopressin (AVP).	Water	104-109	aquaporin 2	Homo sapiens	13-18
28391120-10	2017	Time-course profiles of ACE and the identified by-products in tap water and wastewater samples were followed in order to simulate the actual disinfection process.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
10505693-10	1999	Urinary AQP-2 excretion correlated best with solute-free water clearance during T0-T2 and T2-T4 collection, but a correlation with urinary osmolality and urinary output was also found during these periods.	Water	57-62	aquaporin 2	Homo sapiens	8-13
28391120-11	2017	Tap water did not significantly affect degradation, but wastewater did; it reacted with the ACE to produce several brominated-DBPs.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
10489294-3	1999	The increase in the interlayer distance from 15.02 to 16.36 A on going from KPP-hyd to KPP-hex was attributed to the replacement of water molecules with the longer hexylamine molecules in the phenylphosphonate P-O-H binding sites of the grafted KPP host.	Water	132-137	keratin 10	Homo sapiens	76-79
28659754-14	2017	In vivo inhibition of NOX2 using apocynin in drinking water, or infusion of blocked peptide gp91 phox ds in the VTA normalized alcohol place preference, suggesting that NOX2 plays an important role in addictive like behavior.	Water	54-59	cytochrome b-245 beta chain	Rattus norvegicus	22-26
10489294-3	1999	The increase in the interlayer distance from 15.02 to 16.36 A on going from KPP-hyd to KPP-hex was attributed to the replacement of water molecules with the longer hexylamine molecules in the phenylphosphonate P-O-H binding sites of the grafted KPP host.	Water	132-137	keratin 10	Homo sapiens	87-90
10489294-3	1999	The increase in the interlayer distance from 15.02 to 16.36 A on going from KPP-hyd to KPP-hex was attributed to the replacement of water molecules with the longer hexylamine molecules in the phenylphosphonate P-O-H binding sites of the grafted KPP host.	Water	132-137	keratin 10	Homo sapiens	87-90
10490456-10	1999	Because these AQP3-positive epithelia have a common feature, i.e., they are exposed to an environment of possible water loss, we propose that AQP3 could serve as a water channel to provide these epithelial cells with water from the subepithelial side to protect them against dehydration.	Water	114-119	aquaporin 3 (Gill blood group)	Rattus norvegicus	14-18
28695146-10	2017	Glialcam-null astrocytes showed abolished expression of MLC1, reduced expression of the chloride channel ClC-2 and increased expression and redistribution of the water channel aquaporin4.	Water	162-167	aquaporin 4	Mus musculus	176-186
28648105-7	2017	Our studies suggest that the capacity for water flow across the membrane of MECs may be altered in pSS, identifying AQP4 as a promising new therapeutic agent to treat xerostomia.	Water	42-47	aquaporin 4	Homo sapiens	116-120
10490456-10	1999	Because these AQP3-positive epithelia have a common feature, i.e., they are exposed to an environment of possible water loss, we propose that AQP3 could serve as a water channel to provide these epithelial cells with water from the subepithelial side to protect them against dehydration.	Water	114-119	aquaporin 3 (Gill blood group)	Rattus norvegicus	142-146
10490456-10	1999	Because these AQP3-positive epithelia have a common feature, i.e., they are exposed to an environment of possible water loss, we propose that AQP3 could serve as a water channel to provide these epithelial cells with water from the subepithelial side to protect them against dehydration.	Water	164-169	aquaporin 3 (Gill blood group)	Rattus norvegicus	14-18
10490456-10	1999	Because these AQP3-positive epithelia have a common feature, i.e., they are exposed to an environment of possible water loss, we propose that AQP3 could serve as a water channel to provide these epithelial cells with water from the subepithelial side to protect them against dehydration.	Water	164-169	aquaporin 3 (Gill blood group)	Rattus norvegicus	142-146
28218824-9	2017	In addition, Fmr1-KO mice show significantly less daily water ingestion during the circadian dark cycle, and this reduction in water intake is accompanied by a decrease in the amount of water ingested per lick.	Water	56-61	fragile X messenger ribonucleoprotein 1	Mus musculus	13-17
28218824-9	2017	In addition, Fmr1-KO mice show significantly less daily water ingestion during the circadian dark cycle, and this reduction in water intake is accompanied by a decrease in the amount of water ingested per lick.	Water	127-132	fragile X messenger ribonucleoprotein 1	Mus musculus	13-17
10497058-4	1999	It is demonstrated using a perdeuterated 15N-labeled protein sample, Neural Cell Adhesion Molecule 213-308 (NCAM) from rat, in H2O at 800 MHz.	Water	127-130	neural cell adhesion molecule 1	Rattus norvegicus	108-112
28218824-9	2017	In addition, Fmr1-KO mice show significantly less daily water ingestion during the circadian dark cycle, and this reduction in water intake is accompanied by a decrease in the amount of water ingested per lick.	Water	127-132	fragile X messenger ribonucleoprotein 1	Mus musculus	13-17
28218824-10	2017	The observed water ingestion and circadian phenotypes noted in Fmr1-KO mice recapitulate known clinical aspects previously described in FXS.	Water	13-18	fragile X messenger ribonucleoprotein 1	Mus musculus	63-67
10568266-8	1999	Along the path towards the western Mediterranean, 137Cs content in the Levantine intermediate water decreases from approximately 4 mBq/l in the W-Ionian Sea to approximately 2 mBq/l at the western sill of the Sicily Straits, due to mixing with underlying water, with lower caesium content, near the Malta Sill.	Water	94-99	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	153-156
28587495-1	2017	Manganese superoxide dismutase (MnSOD) is a mitochondrial-resident enzyme that reduces superoxide to hydrogen peroxide (H2O2), which can be further reduced to water by glutathione peroxidase (GPX1).	Water	159-164	glutathione peroxidase 1	Homo sapiens	192-196
28426322-10	2017	A promotional campaign to increase water consumption among these Latino youth should include bicultural messages to underscore the power of water to quench true thirst, highlight the health benefits of drinking water, and address the safety of tap water.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	244-247
10568292-4	1999	The anthropogenic radionuclide data support the idea of fast exchange of water masses in the Caspian Sea.	Water	73-78	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	101-104
16429612-11	1999	The dissociation kinetics for the hexa- and pentahydrated clusters of Ca(2+), Sr(2+), and Ba(2+) are consistent with structures in which all the water molecules are located in the first solvation shell.	Water	145-150	hexosaminidase subunit alpha	Homo sapiens	34-38
27576172-8	2017	When HBSMCs were subjected to 200-300 cm H2 O pressure for 2-24 h in vitro, the expressions of IL-6 and RANTES were significantly increased.	Water	41-45	C-C motif chemokine ligand 5	Homo sapiens	104-110
10460172-0	1999	Heterotetrameric composition of aquaporin-4 water channels.	Water	44-49	aquaporin 4	Rattus norvegicus	32-43
10433839-6	1999	Drinking water from a well in the exposed community demonstrated low level residues of cholinesterase-inhibiting pesticides, although contamination with toxaphene (not a cholinesterase inhibitor) exceeded by over 8-fold the United States Environmental Protection Agency maximum permissible concentration in drinking water.	Water	9-14	butyrylcholinesterase	Homo sapiens	87-101
28659529-5	2017	Tap water with conductivity 248 muS/cm was fed to UF-EDI system.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
28533515-5	2017	Given that p-tau can be released to the extracellular space and that the astroglial water transport via AQP4 is involved in tau clearance from the brain interstitium, our results suggest that regional disruption of AQP4 polarity following TBI may reduce the clearance of the toxic interstitial solutes such as p-tau and lead to changes in dendritic spine density and morphology.	Water	84-89	aquaporin 4	Homo sapiens	104-108
28533515-5	2017	Given that p-tau can be released to the extracellular space and that the astroglial water transport via AQP4 is involved in tau clearance from the brain interstitium, our results suggest that regional disruption of AQP4 polarity following TBI may reduce the clearance of the toxic interstitial solutes such as p-tau and lead to changes in dendritic spine density and morphology.	Water	84-89	aquaporin 4	Homo sapiens	215-219
28526701-9	2017	Administration of exogenous NTN-1 significantly reduced brain water content and BBB permeability and ameliorated neurological deficits at 24 and 72 hours after SAH.	Water	62-67	netrin 1	Rattus norvegicus	28-33
28447461-1	2017	Recrystallization behaviors of water sorbed into four poly(meth)acrylates, poly(2-methoxyethyl acrylate), poly(tetrahydrofurfuryl acrylate), poly(methyl acrylate), and poly(methyl methacrylate), are investigated by variable-temperature mid-infrared (VT-MIR) spectroscopy and molecular dynamics (MD) simulation.	Water	31-36	membrane associated ring-CH-type finger 8	Homo sapiens	253-256
30970859-4	2017	The incorporation of electrospun PLA and PLA/Lip nanofiber mats lowered the moisture regain and water vapor transmission of BC nanocomposites relative to pure BC mats.	Water	96-101	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	45-48
28423683-1	2017	Aquaporin 4 (AQP4) is the major water channel expressed in the central nervous system and is primarily expressed in astrocytes.	Water	32-37	aquaporin 4	Homo sapiens	0-11
28423683-1	2017	Aquaporin 4 (AQP4) is the major water channel expressed in the central nervous system and is primarily expressed in astrocytes.	Water	32-37	aquaporin 4	Homo sapiens	13-17
28167360-2	2017	The sensor displays a rapid and highly selective colorimetric and fluorescence response toward Hg2+ without interference with other metal ions in CH3CN/H2O mixture (50/50, v/v).	Water	152-155	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	95-98
28126464-8	2017	When renorenal reflex is induced, NHE3 exchanger activity appears to be decreased, resulting in decreased sodium and water reabsorption in the contralateral kidney.	Water	117-122	solute carrier family 9 member A3	Homo sapiens	34-38
28288350-3	2017	Benalaxyl decreased with half-life of 16.1 days in soil under tap water irrigation with preferential residue of S-benalaxyl.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
28288350-6	2017	Benalaxyl acid was also formed with similar enantioselectivity as in tap water irrigation.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
28206694-0	2017	Translational readthrough generates new astrocyte AQP4 isoforms that modulate supramolecular clustering, glial endfeet localization, and water transport.	Water	137-142	aquaporin 4	Homo sapiens	50-54
28206694-2	2017	In this context, several lines of evidence suggest a crucial role for the water channel aquaporin-4 (AQP4) and its plasma membrane supramolecular organization as the key element.	Water	74-79	aquaporin 4	Homo sapiens	101-105
28468698-8	2017	The proposed method was successfully applied to the determination of irinotecan in tap water, river water, and urine samples spiked with 10.20 mg/L for the water samples and 8.32 mg/L for the urine sample.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
28341892-1	2017	The water channel aquaporin 4 (AQP4) is abundantly expressed in astrocytes and provides a mechanism by which water permeability of the plasma membrane can be regulated.	Water	4-9	aquaporin 4	Homo sapiens	18-29
28341892-1	2017	The water channel aquaporin 4 (AQP4) is abundantly expressed in astrocytes and provides a mechanism by which water permeability of the plasma membrane can be regulated.	Water	4-9	aquaporin 4	Homo sapiens	31-35
27369695-0	2017	The role of apelin in the healing of water-immersion and restraint stress-induced gastric damage.	Water	37-42	apelin	Rattus norvegicus	12-18
28442005-7	2017	To maintain soil chemistry similar to the field, rain water or tap water should be used in column studies.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
29903263-9	2017	The tap water showed weaker mutagenicities than the raw water in samples with S9( P = 0.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
28497034-2	2017	Because of concern regarding local tap water quality, fluoride-free bottled water consumption is common in this region, raising concern that families are not receiving adequate fluoride to promote dental health.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
28497034-7	2017	RESULTS: Fluoride detection levels were significantly greater (p = 0.02, Fisher"s exact test) in tap water (average = 0.49 mg/dL) than in bottled water, yet, the majority (22/30) were below the range for optimal dental health (0.7-1.2 mg/L).	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
10419965-3	1999	Pdr12 appears to mediate resistance to water-soluble, monocarboxylic acids with chain lengths of from C(1) to C(7).	Water	39-44	ATP-binding cassette multidrug transporter PDR12	Saccharomyces cerevisiae S288C	0-5
10589971-4	1999	Previous administration of the beta2-adrenoceptor agonist clenbuterol reduced Evans blue extravasation and water content, but did not change vesicle frequency.	Water	107-112	adrenoceptor beta 2	Rattus norvegicus	31-49
10409176-8	1999	In addition, chronic intracerebrovetricular infusion of ANG II elicited a significant increase in water intake and in arterial pressure from the first and second day of infusion, respectively.	Water	98-103	ANG	Canis lupus familiaris	56-59
10388766-5	1999	Our estimation of the dodecamer"s BI-to-BII conformer substate population by curve resolution of the symmetrical stretching vibration of the ionic phosphate is 2.4 +/- 0.5 to 1 at 200 K, and it is 1.3 +/- 0.5 to 1 between 270 and 290 K. Pronounced spectral changes upon BI-to-BII interconversion are consistent with base destacking coupled with migration of water from ionic phosphate toward the phosphodiester and sugar moieties.	Water	358-363	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	40-43
10443914-16	1999	We conclude that TPL reduces clinical, biochemical and histopathological severity of S-Ag induced EAU in Lewis rats.	Water	98-101	S-antigen visual arrestin	Rattus norvegicus	85-89
10405197-1	1999	Clinical studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine, and that the excretion increases in response to vasopressin.	Water	79-84	aquaporin 2	Rattus norvegicus	33-44
10405197-1	1999	Clinical studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine, and that the excretion increases in response to vasopressin.	Water	79-84	aquaporin 2	Rattus norvegicus	46-50
10405197-7	1999	In rats with normal water supply, daily urinary excretion of AQP2 was 3.9+/-0.9% (n = 6) of total kidney expression.	Water	20-25	aquaporin 2	Rattus norvegicus	61-65
10405197-9	1999	Moreover, rats that were thirsted for 48 h and subsequently allowed free access to water for 24 h produced a decrease in urinary AQP2 excretion to 38+/-15% (n = 6) of that during thirsting.	Water	83-88	aquaporin 2	Rattus norvegicus	129-133
11969779-7	1999	A low-order simplified dynamical system derived from the one-dimensional shallow-water model is used to show that this optimum time interval Delta t(o) when the zonal wind and the geopotential, for example, are inserted varies approximately as square root of [2]/2 Omega sin phi to accuracy O(Delta t(3)).	Water	81-86	embryonal Fyn-associated substrate	Homo sapiens	271-274
10434802-3	1999	The interactions of GK2 with various drugs were investigated using the 1-octanol/water partition method.	Water	81-86	glycerol kinase 2	Rattus norvegicus	20-23
10435855-2	1999	Moreover, recent studies in rodents have shown that leptin in high doses decreases urine osmolality and increases water intake, together with renal sodium and water excretion.	Water	114-119	leptin	Homo sapiens	52-58
28453240-10	2017	The father as the main child caregiver and lack of access to tap water are risk factors for viral failure and justify a special caution to improve adherence in these easy-to-identify situations before ART initiation.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
10435855-2	1999	Moreover, recent studies in rodents have shown that leptin in high doses decreases urine osmolality and increases water intake, together with renal sodium and water excretion.	Water	159-164	leptin	Homo sapiens	52-58
10349858-4	1999	Approximately 30% of total brain A beta (approximately 122 ng/g of wet tissue) was water-soluble.	Water	83-88	amyloid beta (A4) precursor protein	Mus musculus	33-39
28151660-5	2017	With a [4]:[Hg2+] molar ratio of 5:1 and a single biphasic solvent extraction, the concentration of Hg2+ ions could be reduced drastically by 98% (from 200 to 4 ppb) in pure water.	Water	174-179	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	100-103
10395405-11	1999	Guanylin peptides are clearly involved in the regulation of salt and water homeostasis, but new findings indicate that these novel peptides have diverse physiological roles in addition to those previously documented for control of intestinal and renal function.	Water	69-74	guanylate cyclase activator 2A	Homo sapiens	0-8
28378768-0	2017	A novel label-free fluorescence assay for one-step sensitive detection of Hg2+ in environmental drinking water samples.	Water	105-110	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	74-77
28378768-2	2017	Differences from other assays, the designed rich-thymine (T) ssDNA probe without fluorescent labelling can be rapidly formed a T-Hg2+-T complex and folded into a stable hairpin structure in the presence of Hg2+ in environmental drinking water samples by facilitating fluorescence increase through intercalating with SG I in one-step.	Water	237-242	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	129-132
28378768-2	2017	Differences from other assays, the designed rich-thymine (T) ssDNA probe without fluorescent labelling can be rapidly formed a T-Hg2+-T complex and folded into a stable hairpin structure in the presence of Hg2+ in environmental drinking water samples by facilitating fluorescence increase through intercalating with SG I in one-step.	Water	237-242	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	206-209
28378768-6	2017	This method was highly specific for detecting of Hg2+ without being affected by other possible interfering ions from different background compositions of water samples.	Water	154-159	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	49-52
10329687-2	1999	We have cloned the human Na+-dependent multivitamin transporter (SMVT), which transports the water-soluble vitamins pantothenate, biotin, and lipoate, from a placental choriocarcinoma cell line (JAR).	Water	93-98	solute carrier family 5 member 6	Homo sapiens	25-63
28513780-4	2017	In the animals, the activity of the serum gamma-glutamyltranspeptidase (gamma-GT) was reduced to 1.8 I.U/L in the coconut water group, 3.6 I.U/L in the ascorbic acid group and 2.9 I.U/L in the caffeic acid groups, when compared with the ethanol group (5.1 I.U/L, p&lt;0.05).	Water	122-127	inactive glutathione hydrolase 2	Homo sapiens	42-70
28513780-4	2017	In the animals, the activity of the serum gamma-glutamyltranspeptidase (gamma-GT) was reduced to 1.8 I.U/L in the coconut water group, 3.6 I.U/L in the ascorbic acid group and 2.9 I.U/L in the caffeic acid groups, when compared with the ethanol group (5.1 I.U/L, p&lt;0.05).	Water	122-127	inactive glutathione hydrolase 2	Homo sapiens	72-80
10329687-2	1999	We have cloned the human Na+-dependent multivitamin transporter (SMVT), which transports the water-soluble vitamins pantothenate, biotin, and lipoate, from a placental choriocarcinoma cell line (JAR).	Water	93-98	solute carrier family 5 member 6	Homo sapiens	65-69
10350620-0	1999	Structural properties of human glycodelin A in water and in water-alcohol mixtures: a comparison with bovine beta-lactoglobulin A.	Water	47-52	progestagen associated endometrial protein	Homo sapiens	31-43
28086155-6	2017	In addition, HANs added to tap water exhibited higher removals than those added to ultrapure water, probably because of the presence of free chlorine in tap water.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
28134709-5	2017	RECENT FINDINGS: MAGED2 mutations caused X-linked polyhydramnios with prematurity and a severe but transient form of antenatal Bartter"s syndrome.We distinguish two types of hereditary NDI: a "pure" type with loss of water only and a complex type with loss of water and ions.	Water	217-222	MAGE family member D2	Homo sapiens	17-23
10350620-0	1999	Structural properties of human glycodelin A in water and in water-alcohol mixtures: a comparison with bovine beta-lactoglobulin A.	Water	60-65	progestagen associated endometrial protein	Homo sapiens	31-43
28134709-5	2017	RECENT FINDINGS: MAGED2 mutations caused X-linked polyhydramnios with prematurity and a severe but transient form of antenatal Bartter"s syndrome.We distinguish two types of hereditary NDI: a "pure" type with loss of water only and a complex type with loss of water and ions.	Water	260-265	MAGE family member D2	Homo sapiens	17-23
10350620-2	1999	The structural characteristics of human GdA and beta-LgA were compared in water and 2-propanol/water solutions.	Water	74-79	progestagen associated endometrial protein	Homo sapiens	40-43
10232597-14	1999	Oral feeding of 0.2% GTPs in drinking water for 7 days before testosterone administration resulted in 20 and 54% decreases in testosterone-caused induction of ODC activity in sham-operated and castrated rats, respectively.	Water	38-43	ornithine decarboxylase 1	Rattus norvegicus	159-162
27335016-6	2017	Sum of mean concentrations of eight PFAAs detected in drinking tap water from Leipzig was 11.5 ng L-1, dominated by perfluorooctanoic acid (PFOA, 6.2 ng L-1).	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
28457129-0	2017	Structural Changes in Barley Protein LTP1 Isoforms at Air-Water Interfaces.	Water	58-63	non-specific lipid transport protein 1	Hordeum vulgare	37-41
28457129-1	2017	We use a coarse-grained model to study the conformational changes in two barley proteins, LTP1 and its ligand adduct isoform LTP1b, that result from their adsorption to the air-water interface.	Water	177-182	non-specific lipid transport protein 1	Hordeum vulgare	90-94
10375960-5	1999	Aquaporin-2 (AQP-2) is an AVP-dependent water channel in renal collecting duct cells.	Water	40-45	aquaporin 2	Homo sapiens	0-11
28340788-6	2017	The reliability of NI-MFGDP-MS was characterized by the analysis of a picric acid-RDX-PETN mixture and a mixture of RDX-pond water.	Water	125-130	radixin	Homo sapiens	116-119
28207202-0	2017	The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network.	Water	65-70	tripartite motif containing 24	Homo sapiens	23-29
28207202-3	2017	The crystal structures of two new inhibitors in complex with the TRIM24 bromodomain reveal that the water-bridged interaction network is conserved in the same fashion as those for known benzoimidazolone inhibitors.	Water	100-105	tripartite motif containing 24	Homo sapiens	65-71
10375960-5	1999	Aquaporin-2 (AQP-2) is an AVP-dependent water channel in renal collecting duct cells.	Water	40-45	aquaporin 2	Homo sapiens	13-18
10220332-0	1999	Conformational flexibility of domain III of annexin V at membrane/water interfaces.	Water	66-71	annexin A5	Homo sapiens	44-53
28416871-2	2017	Pure, tap and spring water were tested, and water quality was found to have a distinct effect on the main compounds extracted.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	6-9
28493993-16	2017	This decrease in the NHE-2 expression will lead to a loss of electrolyte and water uptake thus contributing to the symptoms associated with IBD.	Water	77-82	solute carrier family 9 member A2	Rattus norvegicus	21-26
10206998-1	1999	Enhanced osmotic water permeability has been observed in Xenopus oocytes expressing cystic fibrosis transmembrane conductance regulator (CFTR) protein.	Water	17-22	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	84-135
28483828-10	2017	Home tap water consumed as a beverage and dietary supplement and nonprescription antacids contributed minimally to sodium intake (&lt;0.5% each).	Water	9-14	nuclear RNA export factor 1	Homo sapiens	5-8
28340598-6	2017	Demyelination, glial and neuronal viability, and complement pathway activation were assayed by immunofluorescence microscopy and compared to the effects of an aquaporin-4 water channel (AQP4)-specific rAb derived from a neuromyelitis optica (NMO) patient.	Water	171-176	aquaporin 4	Homo sapiens	186-190
28161940-12	2017	If the copper in water is too high, a simple device can be put on the tap to remove copper.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	70-73
28372730-5	2017	The quantitation of STR in honey, milk and tap water confirm the reliability and applicability of the reported method.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
10206998-1	1999	Enhanced osmotic water permeability has been observed in Xenopus oocytes expressing cystic fibrosis transmembrane conductance regulator (CFTR) protein.	Water	17-22	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	137-141
10206998-5	1999	Glycerol uptake and antisense studies suggest CFTR-dependent regulation of aquaporin 3 (AQP3) water channels in airway epithelial cells.	Water	94-99	aquaporin 3 (Gill blood group)	Homo sapiens	75-86
10206998-5	1999	Glycerol uptake and antisense studies suggest CFTR-dependent regulation of aquaporin 3 (AQP3) water channels in airway epithelial cells.	Water	94-99	aquaporin 3 (Gill blood group)	Homo sapiens	88-92
28189835-2	2017	The chemodosimeter S showed an extreme selectivity for detection of Hg2+ ion among various two and three-valent metal ions in acetonitrile/water (70/30, v/v).	Water	139-144	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	68-71
10101216-2	1999	An interesting class of water-soluble nonpolyglutamatable analogs of aminopterin (AMT) have been developed, which are much more cytotoxic because they bind more tightly to dihydrofolate reductase (DHFR) and also utilize the reduced folate carrier (RFC) pathway more efficiently for influx into the cell.	Water	24-29	dihydrofolate reductase	Homo sapiens	172-195
28279921-5	2017	Shifts in the magnitude of structural transitions at the single-molecule scale are explained from the perspective of peptide-ion-water interactions in a library of four unique elastin-like peptide systems.	Water	129-134	elastin	Homo sapiens	176-183
28040539-1	2017	A new model is developed to predict the competitive adsorption isotherms of atrazine, methyl tertiary butyl ether (MTBE), 2-methylisoborneol (2-MIB) and 2,4,6-trichlorophenol onto activated carbons (ACs) in natural water.	Water	215-220	MIB E3 ubiquitin protein ligase 1	Homo sapiens	144-147
28027883-1	2017	Aquaporin-4 (AQP4) is the CNS water channel organized into well-ordered protein aggregates called Orthogonal Arrays of Particles (OAPs).	Water	30-35	aquaporin 4	Homo sapiens	0-11
28027883-1	2017	Aquaporin-4 (AQP4) is the CNS water channel organized into well-ordered protein aggregates called Orthogonal Arrays of Particles (OAPs).	Water	30-35	aquaporin 4	Homo sapiens	13-17
10101216-2	1999	An interesting class of water-soluble nonpolyglutamatable analogs of aminopterin (AMT) have been developed, which are much more cytotoxic because they bind more tightly to dihydrofolate reductase (DHFR) and also utilize the reduced folate carrier (RFC) pathway more efficiently for influx into the cell.	Water	24-29	dihydrofolate reductase	Homo sapiens	197-201
10191086-4	1999	Northern blot analysis showed a single 1.7-kb Aqp2 transcript expressed only in kidney (medulla &gt; cortex); transcript expression was increased approximately 20-fold in 48-h water-deprived mice.	Water	176-181	aquaporin 2	Mus musculus	46-50
27898524-5	2017	Greater uromodulin excretion is associated with markers of volume overload such as fractional excretion of uric acid, sodium and chloride, indicating a possible role in salt and water retention.	Water	178-183	uromodulin	Homo sapiens	8-18
27629271-0	2017	Factors determining the density of AQP4 water channel molecules at the brain-blood interface.	Water	40-45	aquaporin 4	Homo sapiens	35-39
27629271-1	2017	Perivascular endfeet of astrocytes are enriched with aquaporin-4 (AQP4)-a water channel that is critically involved in water transport at the brain-blood interface and that recently was identified as a key molecule in a system for waste clearance.	Water	74-79	aquaporin 4	Homo sapiens	53-64
27629271-1	2017	Perivascular endfeet of astrocytes are enriched with aquaporin-4 (AQP4)-a water channel that is critically involved in water transport at the brain-blood interface and that recently was identified as a key molecule in a system for waste clearance.	Water	74-79	aquaporin 4	Homo sapiens	66-70
27629271-1	2017	Perivascular endfeet of astrocytes are enriched with aquaporin-4 (AQP4)-a water channel that is critically involved in water transport at the brain-blood interface and that recently was identified as a key molecule in a system for waste clearance.	Water	119-124	aquaporin 4	Homo sapiens	53-64
27629271-1	2017	Perivascular endfeet of astrocytes are enriched with aquaporin-4 (AQP4)-a water channel that is critically involved in water transport at the brain-blood interface and that recently was identified as a key molecule in a system for waste clearance.	Water	119-124	aquaporin 4	Homo sapiens	66-70
27629271-7	2017	Our data suggest that irrespective of region, endfoot targeting of alpha-syntrophin is the single most important factor determining the size of the perivascular AQP4 pool and hence the capacity for water transport at the brain-blood interface.	Water	198-203	aquaporin 4	Homo sapiens	161-165
27707640-1	2017	Tap water may not be readily available in numerous places as a first aid for burns and, therefore, tea tree oil products are recommended alternatives.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
28271365-4	2017	The new sequence was tested on lysozyme and bovine pancreatic trypsin inhibitor (BPTI), demonstrating its efficiency in both water suppression and, more excitingly, preserving water-proximate biomolecular resonances in omega2.	Water	125-130	spleen trypsin inhibitor I	Bos taurus	81-85
28271365-4	2017	The new sequence was tested on lysozyme and bovine pancreatic trypsin inhibitor (BPTI), demonstrating its efficiency in both water suppression and, more excitingly, preserving water-proximate biomolecular resonances in omega2.	Water	176-181	spleen trypsin inhibitor I	Bos taurus	81-85
27707640-9	2017	The reduction of skin surface temperature by tap water was significantly greater than that by the other two methods.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
10203352-2	1999	On the apical side, the levels of AQP2 protein are increased in response to both arginine vasopressin and water deprivation.	Water	106-111	aquaporin 2	Rattus norvegicus	34-38
28453731-8	2017	In vivo, pharmacological inhibition of miR-27a/b by locked nucleic acid antisense oligonucleotides significantly reduced pericyte coverage and increased water content in the murine uterus.	Water	153-158	microRNA 27a	Mus musculus	39-46
28220278-3	2017	The probe RD-1 was preliminarily applied to the determination of Cd2+ ion in water samples from river and tap water with satisfying results.	Water	77-82	phosphodiesterase 6B	Homo sapiens	10-14
28271365-6	2017	The 2D NOESY-WaterControl map of BPTI showed strong bound water and exchangeable proton signals in omega1 but these signals were absent in omega2, indicating the possibility of using the new sequence to discriminate bound water and exchangeable proton resonances from non-labile proton resonances with similar chemical shifts to water.	Water	58-63	spleen trypsin inhibitor I	Bos taurus	33-37
28271365-6	2017	The 2D NOESY-WaterControl map of BPTI showed strong bound water and exchangeable proton signals in omega1 but these signals were absent in omega2, indicating the possibility of using the new sequence to discriminate bound water and exchangeable proton resonances from non-labile proton resonances with similar chemical shifts to water.	Water	222-227	spleen trypsin inhibitor I	Bos taurus	33-37
28271365-6	2017	The 2D NOESY-WaterControl map of BPTI showed strong bound water and exchangeable proton signals in omega1 but these signals were absent in omega2, indicating the possibility of using the new sequence to discriminate bound water and exchangeable proton resonances from non-labile proton resonances with similar chemical shifts to water.	Water	222-227	spleen trypsin inhibitor I	Bos taurus	33-37
28220278-3	2017	The probe RD-1 was preliminarily applied to the determination of Cd2+ ion in water samples from river and tap water with satisfying results.	Water	110-115	phosphodiesterase 6B	Homo sapiens	10-14
10203352-4	1999	This study evaluates the effect of either dehydration or water loading on the rat kidney mRNA expression of AQP2, AQP3, and AQP4.	Water	57-62	aquaporin 2	Rattus norvegicus	108-112
10203352-4	1999	This study evaluates the effect of either dehydration or water loading on the rat kidney mRNA expression of AQP2, AQP3, and AQP4.	Water	57-62	aquaporin 3 (Gill blood group)	Rattus norvegicus	114-118
28385286-6	2017	The water-insoluble fraction of psyllium fiber largely contributed to the induction of HSP25 expression, but feeding with other water-insoluble DFs from beet, wheat, and oats failed to induce intestinal HSP25 expression.	Water	4-9	heat shock protein 1	Mus musculus	87-92
28503134-4	2017	Aquaporin 4 (AQP4), the predominant water channel in the brain, is expressed in astrocyte endfeet and plays an important role in brain edema following ischemia.	Water	36-41	aquaporin 4	Homo sapiens	0-11
28385286-9	2017	Taken together, feeding psyllium fiber, especially the water-insoluble fraction, increases intestinal HSP25 expression and suppresses oxidant-induced malondialdehyde production.	Water	55-60	heat shock protein 1	Mus musculus	102-107
28503134-4	2017	Aquaporin 4 (AQP4), the predominant water channel in the brain, is expressed in astrocyte endfeet and plays an important role in brain edema following ischemia.	Water	36-41	aquaporin 4	Homo sapiens	13-17
10203352-4	1999	This study evaluates the effect of either dehydration or water loading on the rat kidney mRNA expression of AQP2, AQP3, and AQP4.	Water	57-62	aquaporin 4	Rattus norvegicus	124-128
10203352-7	1999	Relative to control, water deprivation increased the expression of cortical AQP2, -3, and -4, whereas water loading decreased the cortical and medullar expression of AQP2, -3, and -4.	Water	21-26	aquaporin 2	Rattus norvegicus	76-92
10203352-7	1999	Relative to control, water deprivation increased the expression of cortical AQP2, -3, and -4, whereas water loading decreased the cortical and medullar expression of AQP2, -3, and -4.	Water	102-107	aquaporin 2	Rattus norvegicus	166-182
28420192-6	2017	After administration of TXNIP inhibitor-resveratrol (60 mg/kg), TXNIP small interfering RNA (siRNA) and the PERK inhibitor GSK2656157, TXNIP expression was significantly reduced, accompanied by an attenuation of apoptosis and prognostic indicators, including SAH grade, neurological deficits, brain water content, and blood-brain barrier (BBB) permeability.	Water	299-304	thioredoxin interacting protein	Rattus norvegicus	24-29
10203352-8	1999	Therefore, in addition to AQP2 and -3, AQP4 expression is also regulated by water intake.	Water	76-81	aquaporin 4	Rattus norvegicus	39-43
28420192-6	2017	After administration of TXNIP inhibitor-resveratrol (60 mg/kg), TXNIP small interfering RNA (siRNA) and the PERK inhibitor GSK2656157, TXNIP expression was significantly reduced, accompanied by an attenuation of apoptosis and prognostic indicators, including SAH grade, neurological deficits, brain water content, and blood-brain barrier (BBB) permeability.	Water	299-304	thioredoxin interacting protein	Rattus norvegicus	64-69
28177008-1	2017	[70]Fullerene was dissolved in water by complexation with beta-1,3-glucan using a mechanochemical high-speed vibration milling apparatus.	Water	31-36	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	58-66
10202397-2	1999	We have previously shown that green tea, administered as drinking water, inhibits lung tumor development in A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-l-butanone (NNK), a potent nicotine-derived lung carcinogen found in tobacco.	Water	66-71	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	36-39
28420192-6	2017	After administration of TXNIP inhibitor-resveratrol (60 mg/kg), TXNIP small interfering RNA (siRNA) and the PERK inhibitor GSK2656157, TXNIP expression was significantly reduced, accompanied by an attenuation of apoptosis and prognostic indicators, including SAH grade, neurological deficits, brain water content, and blood-brain barrier (BBB) permeability.	Water	299-304	thioredoxin interacting protein	Rattus norvegicus	64-69
28169026-5	2017	Among the five fluorescent components, those associated to humic-like matter (C1, C3 and C4) showed a similar season variability in the river water feeding the DWTP (which resembled that of UV254 and TOC), whereas the two components associated to protein-like matter (C2 and C5) exhibited a different behavior.	Water	142-147	complement C3	Homo sapiens	39-91
10378234-4	1999	Water maze results were correlated with in vivo electrophysiology and expression of the synaptic protein synaptotagmin (p65).	Water	0-5	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	120-123
28277672-2	2017	The formation of stable PIL Langmuir and Langmuir-Blodgett (LB) monolayers at the air-water and air-solid interfaces is demonstrated.	Water	86-91	serpin family A member 2 (gene/pseudogene)	Homo sapiens	24-27
28184993-1	2017	Pathogenic autoantibodies associated with neuromyelitis optica (NMO) induce disease by targeting aquaporin-4 (AQP4) water channels enriched on astrocytic endfeet at blood-brain interfaces.	Water	116-121	aquaporin 4	Homo sapiens	97-108
28184993-1	2017	Pathogenic autoantibodies associated with neuromyelitis optica (NMO) induce disease by targeting aquaporin-4 (AQP4) water channels enriched on astrocytic endfeet at blood-brain interfaces.	Water	116-121	aquaporin 4	Homo sapiens	110-114
10070020-4	1999	In addition, the contribution of gluconeogenesis to glucose production was determined by the 2H enrichment in C-5/C-2 of blood glucose after intake of 2H2O (5 ml/kg body water).	Water	170-175	complement C5	Homo sapiens	110-113
28348649-3	2017	Aquaporin-4 (AQP4), is a transmembrane water channel protein in the neuropil of the central nervous system that has an important role in water transport in the brain; AQP4 expression is altered in many pathological conditions such as changes in the blood- brain barrier and/or astrocytic activation, including seizures.	Water	39-44	aquaporin 4	Mus musculus	0-11
10070020-4	1999	In addition, the contribution of gluconeogenesis to glucose production was determined by the 2H enrichment in C-5/C-2 of blood glucose after intake of 2H2O (5 ml/kg body water).	Water	170-175	complement C2	Homo sapiens	114-117
28348649-3	2017	Aquaporin-4 (AQP4), is a transmembrane water channel protein in the neuropil of the central nervous system that has an important role in water transport in the brain; AQP4 expression is altered in many pathological conditions such as changes in the blood- brain barrier and/or astrocytic activation, including seizures.	Water	39-44	aquaporin 4	Mus musculus	13-17
28348649-3	2017	Aquaporin-4 (AQP4), is a transmembrane water channel protein in the neuropil of the central nervous system that has an important role in water transport in the brain; AQP4 expression is altered in many pathological conditions such as changes in the blood- brain barrier and/or astrocytic activation, including seizures.	Water	39-44	aquaporin 4	Mus musculus	167-171
10088671-0	1999	Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Muller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains.	Water	63-68	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	140-146
28157645-11	2017	An IRR of 1.26 (95% CI: 0.89-1.79) was found for ever (versus never) having lived at an address with 10mug/L or more arsenic in the drinking water.	Water	141-146	insulin receptor related receptor	Homo sapiens	3-6
10088671-0	1999	Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Muller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains.	Water	63-68	aquaporin 4	Rattus norvegicus	151-155
28271352-5	2017	In this study, soil moisture was controlled by using tap water and NaOH as electrolytes to enhance electromigration and electroosmosis flow.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
28271352-7	2017	Therefore, tap water was the most cost-effective electrolyte to remove As from fine-grained soil.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
10088671-5	1999	These data indicate that AQP4 may mediate the water flux known to be associated with K+ siphoning in the retina.	Water	46-51	aquaporin 4	Rattus norvegicus	25-29
10088671-6	1999	By its highly differentiated distribution of AQP4, the Muller cell may be able to direct the water flux to select extracellular compartments while protecting others (the subretinal space) from inappropriate volume changes.	Water	93-98	aquaporin 4	Rattus norvegicus	45-49
10049739-6	1999	PAH uptake by Xenopus laevis oocytes injected with hOAT1 mRNA is increased 100-fold compared to water-injected oocytes.	Water	96-101	solute carrier family 22 member 6	Homo sapiens	51-56
28088729-2	2017	AOX branches from the main respiratory chain, directly coupling the oxidation of ubiquinol with reduction of oxygen to water.	Water	119-124	uncharacterized protein	Chlamydomonas reinhardtii	0-3
28279171-5	2017	In an effort to resolve these issues, we set out to introduce water permeability in Nicotiana benthamiana XIP1;1alpha (NbXIP1;1alpha), by exchanging amino acid residues of predicted alternative aromatic/arginine (ar/R) selectivity filters of NbXIP1;1alpha for residues constituting the water permeable ar/R selectivity filter of AtTIP2;1.	Water	62-67	delta tonoplast integral protein	Arabidopsis thaliana	329-337
9950956-1	1999	Aquaporin-2 (AQP2), the protein that mediates arginine vasopressin (AVP)-regulated apical water transport in the renal collecting duct, possesses a single consensus phosphorylation site for cAMP-dependent protein kinase A (PKA) at Ser256.	Water	90-95	aquaporin 2	Rattus norvegicus	0-11
9950956-1	1999	Aquaporin-2 (AQP2), the protein that mediates arginine vasopressin (AVP)-regulated apical water transport in the renal collecting duct, possesses a single consensus phosphorylation site for cAMP-dependent protein kinase A (PKA) at Ser256.	Water	90-95	aquaporin 2	Rattus norvegicus	13-17
27870982-6	2017	And both two probes had the possibility of potentially applied in practical applications such as detecting the hypochlorite concentration of tap water and river water.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
9950956-11	1999	The results indicate that AVP stimulates phosphorylation of AQP2 at Ser256 via activation of PKA, supporting the idea that this is one of the first steps leading to increased water permeability in collecting duct cells.	Water	175-180	aquaporin 2	Rattus norvegicus	60-64
10499107-5	1999	The Fe-C and C-O vibrational frequencies of CO-myoglobin have also been studied and the results indicate that CO forms hydrogen bonds to either the distal histidine residue or a water molecule during normal conditions.	Water	178-183	myoglobin	Homo sapiens	47-56
27915157-11	2017	The method was also applied for the analysis of analytes in the blood serum, Vitamine C tablets, and tap water with satisfactory results.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
28124906-4	2017	However, UO22+ partitioning in irradiated [HOOCCH2MIM][NTf2] can largely be recovered after thorough water washing because of the removal of radiolytic products of [NTf2]-.	Water	101-106	nuclear transport factor 2	Homo sapiens	55-59
9888790-3	1999	To facilitate studies of the receptor structure and signaling mechanism, we have expressed the extracellular ANP-binding domain of rat ANP receptor (NPR-ECD) in a water-soluble form.	Water	163-168	neuronal pentraxin receptor	Rattus norvegicus	149-152
28252670-2	2017	Tap water can reflect integrated features of regional hydrological processes and human activities.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
28252670-6	2017	(1) Results yielded the Tap Water Line in China is delta2H = 7.72 delta18O + 6.57 (r2 = 0.95).	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
9880248-1	1999	Remnants have been found of a shallow-water reef that formed during a pause, similar to the Younger Dryas, in the penultimate deglaciation at 130,000 +/- 2000 years ago, when sea level was 60 to 80 meters lower than it is today.	Water	39-44	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	176-179
28124756-5	2017	Moreover, sensor 1 is a convenient visualizing sensor for low levels of Hg2+ (0.1 ppm) in water environment (from colorless to light pink).	Water	90-95	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	72-75
28124756-9	2017	1 shows a unique colorimetric and fluorescent "turn-on" selectivity to Hg2+ over 14 other metal ions with a hypersensitivity in water environment.	Water	128-133	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	71-74
26919570-1	2017	The astrocytic water channel proteins aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are known to be altered in brains affected by several neurodegenerative disorders, including Alzheimer"s disease.	Water	15-20	aquaporin 4	Homo sapiens	61-72
10872456-7	1999	Orthodox aquaporins are water-selective and include AQP2, a vasopressin-regulated water channel in renal collecting duct, in addition to AQP0, AQP4, and AQP5.	Water	82-87	aquaporin 2	Homo sapiens	52-56
26919570-1	2017	The astrocytic water channel proteins aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are known to be altered in brains affected by several neurodegenerative disorders, including Alzheimer"s disease.	Water	15-20	aquaporin 4	Homo sapiens	74-78
27352359-7	2017	SCA6 had elevated free-water values throughout the cerebellum as compared with controls (corrected P < 0.05).	Water	23-28	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	0-4
10872456-8	1999	Multifunctional aquaglyceroporins AQP3, AQP7, and AQP9 are permeated by water, glycerol, and some other solutes.	Water	72-77	aquaporin 3 (Gill blood group)	Homo sapiens	34-38
27352359-8	2017	Importantly, reduced functional activity in the sensorimotor cortex and SMA and increased free-water in the superior cerebellar peduncle and cerebellar lobule V were related to more severe symptoms in SCA6 (all pairs: R 2 >= 0.4 and corrected P < 0.05).	Water	95-100	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	201-205
10591124-7	1999	One of described aquaporins, AQP2, whose localization is confined to kidney collecting duct principal cells, has been found to be a hormone-depending water channel.	Water	150-155	aquaporin 2	Homo sapiens	29-33
27352359-9	2017	Current results demonstrate that impaired functional activity in sensorimotor cortex and SMA and elevated free-water of lobule V and superior cerebellar peduncle are both related to symptom severity, and may provide candidate biomarkers for SCA6.	Water	111-116	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	241-245
9860835-0	1998	The hydrogen-bonding network of water molecules and the peptide backbone in the region connecting Asp83, Gly120, and Glu113 in bovine rhodopsin.	Water	32-37	rhodopsin	Bos taurus	134-143
28394506-0	2017	Lithium Levels in Tap Water and the Mental Health Problems of Adolescents: An Individual-Level Cross-Sectional Survey.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
28394506-1	2017	OBJECTIVE: We investigated the association between lithium level in tap water and mental health problems, including depressive symptoms, anxiety, and aggressive and suicidal behaviors, in a general population of adolescents using a large individual-level dataset.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
28394506-9	2017	The mean lithium concentration in tap water was 0.48 mug/L (SD = 0.52; range, 0.01 to 2.10; skewness = 2.01; kurtosis = 4.04), and it was relatively low compared with previous studies.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
28394506-10	2017	In multivariable regression analysis, lithium level in tap water had an inverse association with depressive symptoms (P = .02) and interpersonal violence (P = .02) but not with suicidal behaviors (suicidal ideation, P = .82; self-harm, P = .46).	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
28394506-11	2017	CONCLUSIONS: Lithium level in tap water was inversely associated with depressive symptoms and interpersonal violence among a general population of adolescents and may have antidepressive and antiaggressive effects.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
9819374-2	1998	In rats, 24 h water restriction increased mean urinary osmolality (Uosm) from 2, 179+/-153 mOsm/kg to 2,944+/-294 mOsm/kg (P &lt; 0.001) and was associated with significant (P &lt; 0.05) increases in the papillary activity of c-Jun NH2-terminal protein kinase (JNK) by 22%, extracellular signal-regulated protein kinase (ERK) by 49%, and p38 MAPK by 15%.	Water	14-19	mitogen-activated protein kinase 8	Rattus norvegicus	226-259
28393003-4	2017	Aquaporin-4 (AQP4), which is the target antigen for a NMO autoantibody, is the predominant CNS water channel.	Water	95-100	aquaporin 4	Homo sapiens	0-11
28393003-4	2017	Aquaporin-4 (AQP4), which is the target antigen for a NMO autoantibody, is the predominant CNS water channel.	Water	95-100	aquaporin 4	Homo sapiens	13-17
9819374-2	1998	In rats, 24 h water restriction increased mean urinary osmolality (Uosm) from 2, 179+/-153 mOsm/kg to 2,944+/-294 mOsm/kg (P &lt; 0.001) and was associated with significant (P &lt; 0.05) increases in the papillary activity of c-Jun NH2-terminal protein kinase (JNK) by 22%, extracellular signal-regulated protein kinase (ERK) by 49%, and p38 MAPK by 15%.	Water	14-19	mitogen-activated protein kinase 8	Rattus norvegicus	261-264
9819374-3	1998	Conversely, 24 h of water-loading (Uosm 473+/-33 mOsm/kg) caused suppression of JNK activity by 43% (P &lt; 0.001), ERK by 39% (P &lt; 0.05), and p38 MAPK by 26% (P &lt; 0.05).	Water	20-25	mitogen-activated protein kinase 8	Rattus norvegicus	80-83
9858776-4	1998	It is pointed out that the local changes of water chemical potential, induced by the binding of MgADP to myosin, can be sensed by other structures of the contractile machinery, which per se may even be insensitive to MgADP.	Water	44-49	myosin heavy chain 14	Homo sapiens	105-111
28065546-5	2017	Furthermore, opportunistic pathogens with 100% identical blaKPC-2 sequence, like Escherichia coli and Kluyvera georgiana, were isolated from both WWTP and its receiving water, whereas no blaKPC-2 carrying bacteria was detected in the upstream.	Water	169-174	KPC-2	Escherichia coli	57-65
28627348-0	2017	[Effect of hydrogen-rich water on the CD34 expression in lesion boundary brain tissue of rats with traumatic brain injury].	Water	25-30	CD34 molecule	Rattus norvegicus	38-42
28071902-4	2017	Reported here is a discrete nonporous copper(II) complex, (H3O)[K(15-crown-5)2][CuCl4], that exhibits reversible SCSC transformation and magnetic change by the chemisorption/desorption of HCl and H2O.	Water	196-199	H3 clustered histone 15	Homo sapiens	59-62
9815137-1	1998	Cultured renal epithelial cells rapidly downregulate expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2).	Water	93-98	aquaporin 2	Rattus norvegicus	107-118
27981479-0	2017	Chemical quality of tap water in Madrid: multicase control cancer study in Spain (MCC-Spain).	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
27981479-4	2017	In the context of the MCC study, our aims were to describe contaminant concentrations in tap water drawn from various sampling points distributed around the region, assess these concentrations by reference to guideline values and study possible differences between the two supply areas.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
27981479-5	2017	Tap water samples were collected from 34 sampling points in 7 towns in the Madrid region (19-29 April 2010), and 23 contaminants (metals, nitrates, disinfection by-product and Mutagen X levels) were quantified.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
28627348-1	2017	OBJECTIVE: To observe the effect of hydrogen-rich water on the CD34 expression and angiogenesis in lesion boundary brain tissue of rats with traumatic brain injury (TBI).	Water	50-55	CD34 molecule	Rattus norvegicus	63-67
28627348-19	2017	CONCLUSIONS: Hydrogen-rich water promote CD34+ cells home to the site of injured tissue in rats with TBI, is involved in angiogenesis, and improve clinical outcomes during brain functional recovery.	Water	27-32	CD34 molecule	Rattus norvegicus	41-45
28132510-8	2017	Here, we additionally use hydrazoic acid (HN3) as another IR probe of which frequency is highly sensitive to its local H-bonding water density.	Water	129-134	MT-RNR2 like 3 (pseudogene)	Homo sapiens	42-45
28132510-9	2017	Interestingly, we found that the vibrational lifetime of the asymmetric azido stretch mode of HN3 in the lipid multibilayer system is similar to that in neat water, whereas its orientational relaxation is a bit slower than that in bulk water.	Water	158-163	MT-RNR2 like 3 (pseudogene)	Homo sapiens	94-97
28132510-9	2017	Interestingly, we found that the vibrational lifetime of the asymmetric azido stretch mode of HN3 in the lipid multibilayer system is similar to that in neat water, whereas its orientational relaxation is a bit slower than that in bulk water.	Water	236-241	MT-RNR2 like 3 (pseudogene)	Homo sapiens	94-97
9815137-1	1998	Cultured renal epithelial cells rapidly downregulate expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2).	Water	93-98	aquaporin 2	Rattus norvegicus	120-125
9826210-1	1998	Aquaporin-2 (AQP-2) encodes the vasopressin-regulated "water channels" of the renal collecting duct and is excreted in human urine.	Water	55-60	aquaporin 2	Homo sapiens	0-11
28103012-0	2017	A Bimodal, Cationic, and Water-Soluble Calix[4]arene Conjugate: Design, Synthesis, Characterization, and Transfection of Red Fluorescent Protein Encoded Plasmid in Cancer Cells.	Water	25-30	tripartite motif containing 27	Homo sapiens	121-144
27596385-5	2017	There was a marked rise of transfer rates when water solubility increased from 20mgL(-1) to 450mgL(-1) and LogKow decreased from 6 to 4.	Water	47-52	LLGL scribble cell polarity complex component 1	Homo sapiens	81-87
27596385-5	2017	There was a marked rise of transfer rates when water solubility increased from 20mgL(-1) to 450mgL(-1) and LogKow decreased from 6 to 4.	Water	47-52	LLGL scribble cell polarity complex component 1	Homo sapiens	95-101
9826210-1	1998	Aquaporin-2 (AQP-2) encodes the vasopressin-regulated "water channels" of the renal collecting duct and is excreted in human urine.	Water	55-60	aquaporin 2	Homo sapiens	13-18
9799415-5	1998	Both the V2-receptor and the AQP-2 water channel were found to be expressed in the ES epithelium.	Water	35-40	aquaporin 2	Homo sapiens	29-34
28059504-5	2017	A SrTiO3:La,Rh/C/BiVO4:Mo sheet is shown to achieve unassisted pure-water (pH 6.8) splitting with a solar-to-hydrogen energy conversion efficiency (STH) of 1.2% at 331 K and 10 kPa, while retaining 80% of this efficiency at 91 kPa.	Water	68-73	saitohin	Homo sapiens	148-151
28059504-6	2017	The STH value of 1.0% is the highest among Z-scheme pure water splitting operating at ambient pressure.	Water	57-62	saitohin	Homo sapiens	4-7
28128831-5	2017	Through regulating the width n of the MX2 region in the MoS2/(MX2)n lateral heterostructures, the optical absorption of the lateral heterostructures under visible light can be increased, and the CBM and VBM states of the lateral heterostructures can be located above the hydrogen reduction potential and below the water oxidation potential, respectively.	Water	314-319	MX dynamin like GTPase 2	Homo sapiens	38-41
28128831-5	2017	Through regulating the width n of the MX2 region in the MoS2/(MX2)n lateral heterostructures, the optical absorption of the lateral heterostructures under visible light can be increased, and the CBM and VBM states of the lateral heterostructures can be located above the hydrogen reduction potential and below the water oxidation potential, respectively.	Water	314-319	MX dynamin like GTPase 2	Homo sapiens	62-65
28134364-2	2017	Each syn- and anti-AAP rotamer has three distinctive binding sites (-OH, &gt;CO, and &gt;NH) for a water molecule, thus 6 different AAP-(H2O)1 conformers are expected to exist in the molecular beam.	Water	99-104	synemin	Homo sapiens	5-8
28134364-2	2017	Each syn- and anti-AAP rotamer has three distinctive binding sites (-OH, &gt;CO, and &gt;NH) for a water molecule, thus 6 different AAP-(H2O)1 conformers are expected to exist in the molecular beam.	Water	137-140	synemin	Homo sapiens	5-8
28134364-3	2017	The origin bands of the AAP(OH)-(H2O)1 and AAP(CO)-(H2O)1 conformers (including their syn- and anti-conformers) in the R2PI spectrum are shifted to red and blue compared to those of the AAP monomer, respectively.	Water	33-36	synemin	Homo sapiens	86-89
28134364-6	2017	Further investigation of the IR-dip spectra has revealed a hydrogen-bonded NH stretching mode, supporting the presence of the syn-AAP(NH)-(H2O)1 conformer.	Water	139-142	synemin	Homo sapiens	126-129
27912978-0	2017	Tap water iontophoresis in the treatment of pediatric hyperhidrosis.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
9799418-8	1998	We conclude that the water permeability of the membrane of hippocampal CA1 pyramidal neurons is low compared to that of other cell types.	Water	21-26	carbonic anhydrase 1	Rattus norvegicus	71-74
27912978-2	2017	Tap water iontophoresis (TWI) involves immersing the affected area in tap water and passing a small electrical current through the area.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
27912978-2	2017	Tap water iontophoresis (TWI) involves immersing the affected area in tap water and passing a small electrical current through the area.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	70-73
9795088-4	1998	Using this simple physicochemical approach, the permeability of a compound through Caco-2 cells by passive diffusion can be predicted from the compounds" distribution coefficient in 1-octanol/water (log D(oct)) and its molecular weight (MW).	Water	192-197	plexin A2	Homo sapiens	199-209
27912978-2	2017	Tap water iontophoresis (TWI) involves immersing the affected area in tap water and passing a small electrical current through the area.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	0-3
27912978-2	2017	Tap water iontophoresis (TWI) involves immersing the affected area in tap water and passing a small electrical current through the area.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
28125038-5	2017	In mouse skin, chronic arsenic exposure through drinking water increases p62 protein levels in the epidermis.	Water	57-62	nucleoporin 62	Mus musculus	73-76
27618271-4	2017	We determined that these episodes were caused by inadequate clearance of chloramine from the tap water used for portable dialysis.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
27618271-6	2017	CONCLUSIONS: Clinicians should be aware of municipal tap water as a potential cause of methemoglobinemia and monitor for excessive levels of oxidants in dialysis water sources.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
9810712-4	1998	GCB showed poor recoveries due to incomplete desorption with the acetonitrile-water gradient used, and memory effects were detected.	Water	78-83	glucosylceramidase beta	Homo sapiens	0-3
28102376-3	2017	In order to investigate the H2O splitting mechanism density functional theory (DFT) was performed on a Ni/Sb-SnO2 surface with oxygen vacancies.	Water	28-31	strawberry notch homolog 2	Homo sapiens	109-112
28453591-0	2017	[The impact of tap water fluoridation on human health].	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
28453591-2	2017	Additional aims are to evaluate whether the Chilean tap water fluoridation program has had any impact on dental health, and analyze the basis for the Chilean elementary school milk fluoridation program, which is targeted at children living in places where tap water has a fluoride concentration less than 0.3 mg/L, without any artificial fluoridation process.	Water	260-265	nuclear RNA export factor 1	Homo sapiens	256-259
27805294-5	2017	Furthermore, we can distinctly observe that the introduction of oxygen vacancies narrows the hybridization orbital between O 2p and Co 3d and optimizes the O p-band center near the Fermi level by X-ray absorption spectroscopy, which greatly improves the catalytic activity of CO oxidation and photocatalytic water splitting.	Water	308-313	immunoglobulin kappa variable 1D-39	Homo sapiens	123-127
27842853-8	2017	The addition of CNFs also improved the water resistance of PVA adhesive and strongly enhanced the mechanical performance in wet conditions, namely over 7% of CNF content.	Water	39-44	NPHS1 adhesion molecule, nephrin	Homo sapiens	16-19
9775439-5	1998	Oral administration of a hot water-extract of Gingyo-san (8.9-12.5 mg/0.25 ml/mouse x 3 per day) significantly reduced fever production and suppressed the rise in IL-1 alpha production to the level in uninfected mice.	Water	29-34	alcohol dehydrogenase, iron containing, 1	Mus musculus	25-28
28103989-5	2017	Then the PRP of the two groups was activated in water bath at 37 C for 1 h. The formation time of PRG was recorded, and the formation situation of PRG was observed within 1 hour of activation.	Water	48-53	proline rich protein BstNI subfamily 3	Homo sapiens	147-150
27788621-3	2017	SOX deficiency was established by feeding rats with a low molybdenum (Mo) diet and adding 200 ppm tungsten (W) to their drinking water.	Water	129-134	sulfite oxidase	Rattus norvegicus	0-3
9775439-5	1998	Oral administration of a hot water-extract of Gingyo-san (8.9-12.5 mg/0.25 ml/mouse x 3 per day) significantly reduced fever production and suppressed the rise in IL-1 alpha production to the level in uninfected mice.	Water	29-34	interleukin 1 alpha	Mus musculus	163-173
28084738-1	2017	The sensitivity of ionic liquids (ILs) to water affects their physical and chemical properties, even at relatively low concentrations, yet the structural thermodynamics of protic IL- (PIL-) water systems at low water concentrations still remains unclear.	Water	190-195	serpin family A member 2 (gene/pseudogene)	Homo sapiens	184-187
9775439-7	1998	When the hot water-extract of each 10 of the crude components of Gingyo-san (an unknown amount extracted from 6.25 mg/0.25 ml/mouse x 3 per day for Saigae Tataricae Cornu and 3.5 mg/0.25 ml/mouse x 3 per day for the other 9) was orally administered to infected mice, 6 showed significant antipyretic activity.	Water	13-18	alcohol dehydrogenase, iron containing, 1	Mus musculus	9-12
28084738-1	2017	The sensitivity of ionic liquids (ILs) to water affects their physical and chemical properties, even at relatively low concentrations, yet the structural thermodynamics of protic IL- (PIL-) water systems at low water concentrations still remains unclear.	Water	190-195	serpin family A member 2 (gene/pseudogene)	Homo sapiens	184-187
27591718-5	2017	Therefore, the proposed biosensing exhibits a high sensitivity toward target Hg2+ with a detection limit of 16 pM, which is far below the limit (10nM) defined by the U.S. Environmental Protection Agency in drinkable water, and is about 10-fold lower than the previously reported aptamer-based assays for Hg2+.	Water	216-221	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	77-80
28084738-4	2017	(3) Self-association of water in both PIL-water systems leading to the presence of large aggregates of water in IL-rich compositions has been inferred.	Water	24-29	serpin family A member 2 (gene/pseudogene)	Homo sapiens	38-41
9750952-5	1998	Amylin stimulates sodium/water reabsorption from the basolateral side of the proximal tubules and plays a role in sodium homeostasis.	Water	25-30	islet amyloid polypeptide	Rattus norvegicus	0-6
28084738-4	2017	(3) Self-association of water in both PIL-water systems leading to the presence of large aggregates of water in IL-rich compositions has been inferred.	Water	42-47	serpin family A member 2 (gene/pseudogene)	Homo sapiens	38-41
28084738-4	2017	(3) Self-association of water in both PIL-water systems leading to the presence of large aggregates of water in IL-rich compositions has been inferred.	Water	42-47	serpin family A member 2 (gene/pseudogene)	Homo sapiens	38-41
27569775-10	2017	It has been successfully applied in the optical detection of Hg2+ in real water samples.	Water	74-79	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	61-64
28045257-5	2017	This frustration is harnessed by guest exchange to yield a very broad array of spin transition characters in the one framework lattice (one- (1 (H2O,EtOH)), two- (1 3H2O) and three-stepped (1 ~2H2O) transitions and SCO-deactivation (1)).	Water	145-148	spindlin 1	Homo sapiens	79-83
9756090-1	1998	A series of recent studies have demonstrated that expression of aquaporin-2 (AQP2), the vasopressin-regulated water channel of the kidney collecting duct, is greatly reduced in acquired forms of nephrogenic diabetes insipidus (NDI).	Water	110-115	aquaporin 2	Homo sapiens	64-75
28086891-4	2017	This study is concerned with the initial development of a method to measure an electrocardiogram (ECG) through tap water without conscious awareness of the presence of electrodes that are placed outside the bathtub wall.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
9756090-1	1998	A series of recent studies have demonstrated that expression of aquaporin-2 (AQP2), the vasopressin-regulated water channel of the kidney collecting duct, is greatly reduced in acquired forms of nephrogenic diabetes insipidus (NDI).	Water	110-115	aquaporin 2	Homo sapiens	77-81
9756091-6	1998	V2 receptor antagonists correct the impaired solute-free water excretion seen in rats with low-output cardiac failure and reverse the upregulation of renal aquaporin-2 water channels.	Water	168-173	aquaporin 2	Rattus norvegicus	156-167
27936607-3	2017	In this study we formulated a NP coated with a pH-sensitive polymer of O6-methylguanine-DNA methyltransferase (MGMT) inhibitor analog, dialdehyde modified O6-benzylguanosine (DABGS) to achieve high drug loading, and polyethylene glycol (PEG) to ameliorate water solubility and maintain NP stability.	Water	256-261	O-6-methylguanine-DNA methyltransferase	Homo sapiens	111-115
9756091-14	1998	Upregulation of the water channel aquaporin-2 in the renal papillae of pregnant rats has also been demonstrated, and this effect is reversed by administration of a V2 receptor antagonist.	Water	20-25	aquaporin 2	Rattus norvegicus	34-45
9687494-6	1998	Hence, Pdr12 confers weak acid resistance by mediating energy-dependent extrusion of water-soluble carboxylate anions.	Water	85-90	ATP-binding cassette multidrug transporter PDR12	Saccharomyces cerevisiae S288C	7-12
27443479-10	2017	CONCLUSION: Increased AQP1 and AQP4 levels in the heart tissue may be correlated with the maintenance of water and electrolytes balance, which decreases with aging.	Water	105-110	aquaporin 4	Mus musculus	31-35
9692990-7	1998	Hence, an important role determining the ATPase activity at the active site of myosin appears to be a strategic positioning of this in-line water molecule.	Water	140-145	myosin heavy chain 14	Homo sapiens	79-85
27876141-3	2017	The allowed concentration in tap water is 2 10-7 mol L-1.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
27876141-4	2017	SMX could unintentionally be ingested by healthy people when drinking contaminated tap water, representing unnecessary drug intake.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
27876141-5	2017	To assess the quality of tap water, fast, specific and sensitive detection methods are required, in which consequence measures for improving the purification of water might be initiated in the short term.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
27876141-5	2017	To assess the quality of tap water, fast, specific and sensitive detection methods are required, in which consequence measures for improving the purification of water might be initiated in the short term.	Water	161-166	nuclear RNA export factor 1	Homo sapiens	25-28
9744081-2	1998	We hypothesised that a water-soluble growth factor exists which mediates a signal from motor nerves to muscles.	Water	23-28	myotrophin	Rattus norvegicus	37-50
28794322-0	2017	Experimental Confirmation of SrF(CH3F)0-4+ and SrF(H2O)(CH3F)0-3+ Cluster Ions Generated in the Reaction-cell of ICP-QMS/QMS.	Water	51-54	serum response factor	Homo sapiens	47-50
28794322-3	2017	As results, SrF(CH3F)0-4+ and SrF(H2O)(CH3F)0-3+ cluster ions were experimentally confirmed in the present work, while SrF(H2O)(CH3F)0-3+ cluster ions in the reaction-cell of ICP-QMS/QMS were observed and confirmed for the first time in the world.	Water	34-37	serum response factor	Homo sapiens	30-33
28794322-3	2017	As results, SrF(CH3F)0-4+ and SrF(H2O)(CH3F)0-3+ cluster ions were experimentally confirmed in the present work, while SrF(H2O)(CH3F)0-3+ cluster ions in the reaction-cell of ICP-QMS/QMS were observed and confirmed for the first time in the world.	Water	34-37	serum response factor	Homo sapiens	30-33
28794322-3	2017	As results, SrF(CH3F)0-4+ and SrF(H2O)(CH3F)0-3+ cluster ions were experimentally confirmed in the present work, while SrF(H2O)(CH3F)0-3+ cluster ions in the reaction-cell of ICP-QMS/QMS were observed and confirmed for the first time in the world.	Water	123-126	serum response factor	Homo sapiens	12-15
9744081-7	1998	], who originally purified a water-soluble growth factor from cardiac muscles.	Water	29-34	myotrophin	Rattus norvegicus	43-56
9702715-4	1998	The radical-reducing ability in rats was enhanced differently by Vit-E, ID, and Vit-C, i.e., slow onset of the ability after Vit-E and ID (lipid-soluble antioxidants) and fast onset after Vit-C (a water-soluble antioxidant).	Water	197-202	vitrin	Rattus norvegicus	65-68
28770221-6	2017	Collectively, carbohydrate-electrolyte beverage intake may attenuate an increase in HR at a given AEE while mountaineering at ~3000 m compared with tap water intake.	Water	152-157	nuclear RNA export factor 1	Homo sapiens	148-151
9702715-4	1998	The radical-reducing ability in rats was enhanced differently by Vit-E, ID, and Vit-C, i.e., slow onset of the ability after Vit-E and ID (lipid-soluble antioxidants) and fast onset after Vit-C (a water-soluble antioxidant).	Water	197-202	vitrin	Rattus norvegicus	80-83
28164127-8	2017	These data suggest that the upregulation in the expression of NKCC2 in apical membranes during the postobstructive phase of BUO could contribute to improving the excretion of sodium and consequently also the excretion of potassium, osmolytes, and water.	Water	247-252	solute carrier family 12 member 1	Rattus norvegicus	62-67
9702715-4	1998	The radical-reducing ability in rats was enhanced differently by Vit-E, ID, and Vit-C, i.e., slow onset of the ability after Vit-E and ID (lipid-soluble antioxidants) and fast onset after Vit-C (a water-soluble antioxidant).	Water	197-202	vitrin	Rattus norvegicus	80-83
9702715-4	1998	The radical-reducing ability in rats was enhanced differently by Vit-E, ID, and Vit-C, i.e., slow onset of the ability after Vit-E and ID (lipid-soluble antioxidants) and fast onset after Vit-C (a water-soluble antioxidant).	Water	197-202	vitrin	Rattus norvegicus	80-83
9820649-2	1998	The activation of phospholipases A2, C and D (PLA2, PLC and PLD) acting on phosphatidylcholine and phosphatidylethanolamine was determined by high performance liquid chromatography (HPLC) separation and liquid scintillation counting of water- and lipid-soluble phospholipid metabolites.	Water	236-241	LOC104974671	Bos taurus	18-44
28337451-3	2017	Water absorption experiments indicated that both bare AZ31B and PRP/AZ31B were capable of absorbing large amounts of water.	Water	0-5	proline rich protein 2-like 1	Rattus norvegicus	64-67
28337451-3	2017	Water absorption experiments indicated that both bare AZ31B and PRP/AZ31B were capable of absorbing large amounts of water.	Water	117-122	proline rich protein 2-like 1	Rattus norvegicus	64-67
28337451-4	2017	But the water absorption ratio for PRP/AZ31B was significantly higher than that for bare AZ31B.	Water	8-13	proline rich protein 2-like 1	Rattus norvegicus	35-38
9634599-6	1998	Injections of water that damaged the hippocampal dentate gyrus, cortical lesions or eye enucleation decreased the number of CR-cells in the CA1 subfield, reflected in a shift from the CR-staining subclass to the non-CR subclass.	Water	14-19	carbonic anhydrase 1	Rattus norvegicus	140-143
28714415-1	2017	Current experimental evidence points to the conclusion that aquaporin 4 (AQP4), which is an important water-channel membrane protein found in the brain, could play major roles in various brain conditions pathologically including pathogenesis of Alzheimer"s disease (AD).	Water	102-107	aquaporin 4	Homo sapiens	60-71
28714415-1	2017	Current experimental evidence points to the conclusion that aquaporin 4 (AQP4), which is an important water-channel membrane protein found in the brain, could play major roles in various brain conditions pathologically including pathogenesis of Alzheimer"s disease (AD).	Water	102-107	aquaporin 4	Homo sapiens	73-77
9702173-3	1998	EAU was induced by injecting Lewis rats with retinal S-antigen in complete Freund"s adjuvant.	Water	0-3	S-antigen visual arrestin	Rattus norvegicus	45-62
27844316-8	2017	Furthermore, the maximum concentrations in raw water of WTPs was kept at 82.1 ng L-1 for 2-MIB, 5.6 ng L-1 for geosmin, and 66.1 ng L-1 for beta-ionone.	Water	47-52	MIB E3 ubiquitin protein ligase 1	Homo sapiens	91-94
9652834-4	1998	A total of 300 microg of GM-CSF in 250 cc of water for 1 h of mouthwashing was prescribed.	Water	45-50	colony stimulating factor 2	Homo sapiens	25-31
27864825-3	2017	Our aim was to evaluate the relation between T2 values and two molecules associated with brain water homeostasis aquaporin 4 (AQP4) and chondroitin sulfate proteoglycan (CSPG), as well as cellular populations in the hippocampal region of patients with TLE.	Water	95-100	aquaporin 4	Homo sapiens	126-130
9681696-0	1998	Urinary excretion of aquaporin-2 in disorders of water metabolism.	Water	49-54	aquaporin 2	Homo sapiens	21-32
27507462-5	2017	Furthermore, Hg(II) from tap water samples was analyzed, and the results were confirmed by ICP-MS.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
27507462-7	2017	The approach provides a simple, sensitive, and practical tool for the detection of trace Hg(II) in tap water, showing great promise for in-situ applications.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
9848203-1	1998	Effects of water-soluble form of linoleic-hydroxamic acid, inhibitor of lipoxygenase, on process of atherogenesis (alimentary model) were studied at rabbits.	Water	11-16	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	72-84
26991256-4	2017	AQP4 allows the movement of water between astrocyte and the ECS and the microvessels.	Water	28-33	aquaporin 4	Homo sapiens	0-4
9675576-5	1998	Tap water followed by UVB and UVB alone served as controls.	Water	4-9	filamin B	Homo sapiens	0-3
28598849-4	2017	With the model, we here characterized the TG mouse cognitive behaviors and found that Ubqln1 TG mice showed better spatial learning and memory capabilities than their wild-type littermates in both radial arm water maze and Y-maze tests.	Water	208-213	ubiquilin 1	Mus musculus	86-92
9675576-11	1998	The results from the present study indicate that soaking the skin with salt solutions or tap water increases skin sensitivity to subsequent UVB irradiation.	Water	93-98	filamin B	Homo sapiens	89-92
9720659-1	1998	Beta-2 microglobulin (beta2m), the water soluble extrinsic light chain of class I MHC, has been recently isolated from the adult bone culture medium.	Water	35-40	beta-2-microglobulin	Homo sapiens	0-20
28348920-6	2017	The absorbance-concentration plot corresponding to tap water spiked samples was rectilinear, over the range of 7.56 x 10-6-3.22 x 10-5 mol L-1, with detection and quantitation limits of 2.49 x 10-6 mol L-1 and 7.56 x 10-6 mol L-1, respectively.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
26767580-4	2017	Aquaporin 4 (AQP4), a brain water channel, has become a focus of interest for therapeutic approaches targeting edema.	Water	28-33	aquaporin 4	Mus musculus	0-11
26767580-4	2017	Aquaporin 4 (AQP4), a brain water channel, has become a focus of interest for therapeutic approaches targeting edema.	Water	28-33	aquaporin 4	Mus musculus	13-17
9720659-1	1998	Beta-2 microglobulin (beta2m), the water soluble extrinsic light chain of class I MHC, has been recently isolated from the adult bone culture medium.	Water	35-40	beta-2-microglobulin	Homo sapiens	22-28
9570850-4	1998	The major DNPH-labeled product was isolated from the native insulin on reverse-phase HPLC, using trifluoroacetic acid/water/acetonitrile gradients.	Water	118-123	insulin	Bos taurus	60-67
27838476-4	2017	The simulation results show that the diffusion coefficient of water molecules and fractional free volume (FFV) of blend membranes increase with the addition of PAM, and a higher temperature can also improve the diffusion of water molecules.	Water	62-67	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	160-163
27838476-4	2017	The simulation results show that the diffusion coefficient of water molecules and fractional free volume (FFV) of blend membranes increase with the addition of PAM, and a higher temperature can also improve the diffusion of water molecules.	Water	224-229	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	160-163
27838476-5	2017	Additionally, the analysis of PCFs reveals the main reason why the diffusion coefficient of water in blend system increases with the addition of PAM.	Water	92-97	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	145-148
9570029-1	1998	Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel of the renal collecting duct and is excreted in human urine.	Water	47-52	aquaporin 2	Homo sapiens	13-18
27913309-5	2017	Loss of function mutations in the gene encoding the Caenhorhabditis elegans DAT (dat-1) produces rapid immobility when animals are placed in water, a phenotype termed swimming-induced paralysis (Swip).	Water	141-146	solute carrier family 6 member 3	Homo sapiens	76-79
27913309-5	2017	Loss of function mutations in the gene encoding the Caenhorhabditis elegans DAT (dat-1) produces rapid immobility when animals are placed in water, a phenotype termed swimming-induced paralysis (Swip).	Water	141-146	solute carrier family 6 member 3	Homo sapiens	81-86
28054546-1	2017	In emerging optoelectronic applications, such as water photolysis, exciton fission and novel photovoltaics involving low-dimensional nanomaterials, hot-carrier relaxation and extraction mechanisms play an indispensable and intriguing role in their photo-electron conversion processes.	Water	49-54	alcohol dehydrogenase iron containing 1	Homo sapiens	56-59
28496063-0	2017	Fabrication of Water-soluble Fluorescent Polymeric Micelles for Selective Detection of Hg2+ in Blood Serum.	Water	15-20	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	87-90
9570029-4	1998	Our results demonstrate that AQP-2 water channels are expressed in the renal collecting duct of both term and preterm infants.	Water	35-40	aquaporin 2	Homo sapiens	29-34
28496063-2	2017	Subsequently, Hg2+-sensitive water-soluble fluorescent polymeric micelles (FNs) were prepared by a reprecipitation strategy.	Water	29-34	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	14-17
27978530-4	2017	AQP4 is expressed in astrocyte foot processes and ependymal cells lining ventricles, where it appears to facilitate the transport of excess water out of the brain.	Water	140-145	aquaporin 4	Homo sapiens	0-4
9576176-3	1998	Incubation of HUVEC with humic acid (HA) isolated from the drinking water, as a synthetic humic acid polymer (SHA) or with commercial HA, resulted in a dose-dependent reduction of cell surface thrombomodulin activity.	Water	68-73	thrombomodulin	Homo sapiens	193-207
27978530-6	2017	Though significant questions remain, including the precise contribution of AQP1 to CSF secretion in humans and the mechanisms by which AQP4 facilitates clearance of excess brain water, AQP1 and AQP4 have been proposed as potential drug targets to reduce ventricular enlargement in hydrocephalus.	Water	178-183	aquaporin 4	Homo sapiens	135-139
28613122-4	2017	Concerns regarding the taste, smell, and colour of tap water were associated with lower odds of consuming tap water.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
28613122-4	2017	Concerns regarding the taste, smell, and colour of tap water were associated with lower odds of consuming tap water.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	106-109
28613122-4	2017	Concerns regarding the taste, smell, and colour of tap water were associated with lower odds of consuming tap water.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	51-54
28613122-4	2017	Concerns regarding the taste, smell, and colour of tap water were associated with lower odds of consuming tap water.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	106-109
9530269-6	1998	The technique was able to detect an approximately twofold increase in the abundance of mRNA coding for the water channel aquaporin 3 (AQP3), in response to a 30-h dehydration period.	Water	107-112	aquaporin 3 (Gill blood group)	Rattus norvegicus	134-138
29181221-5	2017	Sensing of bromides was also explored in tap water after addition of bromides suggesting that herein prepared catalysts could be used for bromides detection in real samples.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
9485402-2	1998	Equilibrium unfolding experiments indicate that, despite the lack of both disulfide bonds and prosthetic groups, Fyn-SH3 is relatively stable with a free energy of folding of -6.0 +/- 0.6 kcal mol-1 at 20 degrees C. Kinetic experiments indicate that the domain refolds in a rapid two-state manner without significant population of intermediates (k = 94.3 s-1 in H2O at 20 degrees C).	Water	362-365	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	113-116
28063494-2	2017	Gastric lipase, for instance, shows an apparent optimum activity on triglycerides (TAG) at acidic pH, which is controlled by its pH-dependent adsorption at lipid-water interfaces.	Water	162-167	lipase F, gastric type	Canis lupus familiaris	0-14
28513413-1	2017	- The "Traumatic wounds and bite wounds" treatment guideline by the NHG (Dutch College of General Practitioners) has recommendations for treating traumatic wounds, bite wounds and wound infection.- It is important to distinguish between traumatic wounds and bite wounds because treatment of lacerations and cuts differs from treatment of bites.- Clean a wound under a lukewarm water tap; avoid using disinfectants.- Preferably close traumatic wounds within 12 hours, provided that the wounds have been carefully cleaned and that there are no referral indications.	Water	377-382	nuclear RNA export factor 1	Homo sapiens	383-386
27744160-4	2017	The results showed that an increase of water P from 0.02mgL-1 to 0.20 and 2.4mgL-1 generally led to intensified decrease of DGT-labile metals from the 10th to 20th days after the onset of incubation.	Water	39-44	LLGL scribble cell polarity complex component 1	Homo sapiens	56-61
9484218-3	1998	The positive shifts observed in the voltammetric measurements appear to originate from the formation of a complex between cytochrome b5 and the modified electrode surface which (a) neutralizes the charge on the heme propionate located on the exposed heme edge and (b) lowers the dielectric of the exposed heme microenvironment by excluding water from the complex interface, factors which result in the destabilization of the positive charge on the ferric heme with respect to the neutral ferrous heme.	Water	340-345	cytochrome b5 type A	Homo sapiens	122-135
27768907-5	2017	Water-soluble inorganic ions were the most abundant species in both PM1 and PM2.5, followed by organic mass (OM).	Water	0-5	transmembrane protein 11	Homo sapiens	68-71
27768907-9	2017	The water content in PM1 and PM2.5 was enhanced by the water-soluble components, especially NH4NO3.	Water	4-9	transmembrane protein 11	Homo sapiens	21-24
27768907-9	2017	The water content in PM1 and PM2.5 was enhanced by the water-soluble components, especially NH4NO3.	Water	55-60	transmembrane protein 11	Homo sapiens	21-24
27841421-1	2016	The possibility of performing photochemical water splitting in a two-stage system, separately releasing the H2 and O2 components, has been probed with two separate catalysts and in combination with a formaldehyde/formate shuttling redox couple.	Water	44-49	relaxin 2	Homo sapiens	108-117
27664766-8	2017	Cost analysis shows that the capital cost could be returned back in 1 to 4years depending on the choice of produced water (bottled or tap) and available market.	Water	116-121	nuclear RNA export factor 1	Homo sapiens	134-137
28884735-7	2017	CONCLUSION: The results of the long-term observations confirmed the enhanced effectiveness of the spa and health resort-based treatment of metabolic syndrome including the therapeutic courses with the intake of cooled narzan mineral water in the combination with phytococktails.	Water	233-238	surfactant protein A2	Homo sapiens	98-101
31457204-8	2016	Specifically, we have examined the standard electrode potential of the ferrocenium/ferrocene redox couple, Fc+/Fc, and the absolute intrinsic standard chemical potential of a proton in [emim+][NTf2 -], finding that the proton is more acidic in the IL than in water by 6.5 +- 0.6 units on the unified pH scale.	Water	259-264	nuclear transport factor 2	Homo sapiens	193-197
27993072-6	2016	At pH 6.0 and a chlorine dose representative of drinking water treatment, Cl2O is predicted to have at best a minor impact on chlorination reactions, whereas Cl2 may contribute more than 80% to the overall chlorination rate depending on the (chloro)phenol identity and chloride concentration.	Water	57-62	endogenous retrovirus group W member 5	Homo sapiens	74-77
28118131-8	2016	The proposed method was successfully applied to the determination of irinotecan in tap water, river water, and urine samples spiked with 10.20 mg/L for the water samples and 8.32 mg/L for the urine sample.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
27960328-3	2016	We show that femtosecond mid-IR pump-probe spectroscopy using three different IR probes, HDO, HN3, and azido-derivatized crowder, provides complete and stereoscopic information on water structure and dynamics in the cytoplasm-like macromolecular crowding environment.	Water	180-185	MT-RNR2 like 3 (pseudogene)	Homo sapiens	94-97
27922051-1	2016	Urate oxidase (Uox) catalyses the first reaction of oxidative uricolysis, a three-step enzymatic pathway that allows some animals to eliminate purine nitrogen through a water-soluble compound.	Water	169-174	urate oxidase	Danio rerio	0-13
27922051-1	2016	Urate oxidase (Uox) catalyses the first reaction of oxidative uricolysis, a three-step enzymatic pathway that allows some animals to eliminate purine nitrogen through a water-soluble compound.	Water	169-174	urate oxidase	Danio rerio	15-18
27686719-1	2016	A water-circulating column photobioreactor (WCC-PBR) was developed to decrease bubble generation time and mixing time for growing microalgal biomass at low energy consumption.	Water	2-7	translocator protein	Homo sapiens	48-51
27546066-0	2016	Epidemiological investigation of a tap water-mediated hepatitis E virus genotype 4 outbreak in Zhejiang Province, China.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
27655616-0	2016	Occurrence of cardiovascular drugs in the sewage-impacted Vistula River and in tap water in the Warsaw region (Poland).	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
27655616-4	2016	The aim of our study was to determine the presence of 30 pharmaceutically active compounds and some of their metabolites, at specific points of the Vistula River and in tap water samples in the Warsaw region.	Water	173-178	nuclear RNA export factor 1	Homo sapiens	169-172
27655616-8	2016	In tap water samples, trace amounts of pharmaceuticals were detected, for almost all target compounds.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
27876971-10	2016	were found in 25 (73.53 %) out of 34 environmental water samples and 17 (28.8 %) out of 59 tap water.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
27687077-5	2016	When the substances with the cited hazard statement codes react with water or an acid, they can release HCl, Cl2, HF, HCN, PH3, H2S, SO2 (and two other gases very unlikely to be emitted, hydrazoic acid HN3 and selenium oxide SeO2 - a solid with low vapor pressure).	Water	69-74	endogenous retrovirus group W member 5	Homo sapiens	109-112
27687077-5	2016	When the substances with the cited hazard statement codes react with water or an acid, they can release HCl, Cl2, HF, HCN, PH3, H2S, SO2 (and two other gases very unlikely to be emitted, hydrazoic acid HN3 and selenium oxide SeO2 - a solid with low vapor pressure).	Water	69-74	MT-RNR2 like 3 (pseudogene)	Homo sapiens	202-205
27942212-5	2016	Next, we prepared multiple water-in-oil-in-water nanoemulsions incorporating OXA/DCK and 5-FU to enhance their oral absorption.	Water	43-48	deoxycytidine kinase	Mus musculus	81-84
28070256-10	2016	Dissatisfaction from production of foam, unsuitable taste, unacceptable appearance and other problems in tap water was 11.1, 95.6, 27.8 and 0.4% respectively.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	105-108
27781418-1	2016	A copper-catalyzed Ullmann-type amination with primary amines in water with a combination of copper(II) triflate [Cu(OTf)2 ], dipivaloylmethane, and d-glucose is reported.	Water	65-70	POU class 2 homeobox 2	Homo sapiens	117-122
27886114-9	2016	We also evaluated virtual screening performance of AutoDock-GIST using FXa ligands in the directory of useful decoys-enhanced (DUD-E), thus finding that the displacing gain of unfavorable water is effective for a successful docking campaign.	Water	188-193	coagulation factor X	Homo sapiens	71-74
27853241-4	2016	Supplementing drinking water with D-serine (600 mg/L from P28 to P56) prevented the onset of cognitive deficits in adult offspring after MIA, in a significant manner.	Water	23-28	golgi SNAP receptor complex member 1	Homo sapiens	58-61
27711734-5	2016	When applied to a photocatalyst for H2 production from water containing methanol under simulated solar light, the layered titanate/P25 mixture showed considerably enhanced activity and the apparent quantum yield was 23% (at 320 nm).	Water	55-60	tubulin polymerization promoting protein	Homo sapiens	131-134
27664542-5	2016	The formation of three volatile DBPs (NCl3, CHCl3 and CNCHCl2) was observed to be linearly correlated with chloride concentration, both in bench experiments and in actual swimming pool water samples.	Water	185-190	calpain 5	Homo sapiens	38-42
27694043-8	2016	Scanning environmental microscope analysis revealed that sludge flocs conditioned by Alb and Alc (especially PAC2.5 and Al13) exhibited obvious botryoidal structure, this is because sludge flocs formed by Alb and Alc were more compact and floc strength is high, it was easy generated plentiful tiny channels for water release.	Water	312-317	proteasome assembly chaperone 2	Homo sapiens	109-113
27758108-1	2016	Intentional oxidation of an As2-decapped (100) In0.57Ga0.43As substrate by additional H2O dosing during initial Al2O3 gate dielectric atomic layer deposition (ALD) increases the interface trap density (Dit), lowers the band edge photoluminescence (PL) intensity, and generates Ga-oxide detected by X-ray photoelectron spectroscopy (XPS).	Water	86-89	TRAP	Homo sapiens	188-192
27824119-6	2016	Supplementation of a TrkB agonist 7,8-dihydroxyflavone (1 mg/mL in drinking water) during juvenile and adolescent stages could prevent these behavioral abnormalities, reduced BDNF-TrkB signaling in PFC and CA1, and immunoreactivity of PV and PGC-1alpha in the PrL of medial PFC and CA1 in the adult offspring from poly(I:C)-treated mice.	Water	76-81	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	21-25
27318735-2	2016	In this study, a novel anatase/titanate nanosheet composite material (labeled as TNS) synthesized through a one-step hydrothermal reaction was demonstrated to achieve the goal of simultaneous removal of Cr(VI) and 4-cholophenol (4-CP) from water.	Water	240-245	tensin 1	Homo sapiens	81-84
27167210-8	2016	CPAP at 10 cm H2O decreased right atrial size and right ventricular relaxation in all patients.	Water	14-17	centromere protein J	Homo sapiens	0-4
27722387-3	2016	Conductometric and freezing point depression measurements further confirmed that in this process water soluble species are formed as a result of a reaction between the CaTar(s) and the hydroxide ion (or, conversely, between Ca(OH)2(s) and the Tar2- ion).	Water	97-102	trace amine associated receptor 2	Homo sapiens	243-247
27668357-2	2016	In most patients, an IgG autoantibody binding to astrocytic aquaporin 4, the principal water channel of the central nervous system, is detected.	Water	87-92	aquaporin 4	Homo sapiens	60-71
27723961-5	2016	The visible light (lambda &gt; 400 nm) driven photocatalytic properties of CNF@SnS2 are evaluated by the reduction of water-soluble Cr(VI).	Water	118-123	NPHS1 adhesion molecule, nephrin	Homo sapiens	75-78
27782220-0	2016	Improvement of Terahertz Wave Radiation for InAs Nanowires by Simple Dipping into Tap Water.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
27782220-1	2016	We report improvement of terahertz (THz) wave radiation for Si-based catalyst-free InAs nanowires (NWs) by simple dipping into tap water (DTW).	Water	131-136	nuclear RNA export factor 1	Homo sapiens	127-130
27492252-1	2016	Molecular clip 1 remains monomeric in water and engages in host-guest recognition processes with suitable guests.	Water	38-43	CAP-Gly domain containing linker protein 1	Homo sapiens	10-16
27551042-8	2016	Consistent with these results, urinary excretion of water and electrolytes was higher in VAMP3 knock-out mice, which produced more diluted urine.	Water	52-57	vesicle-associated membrane protein 3	Mus musculus	89-94
27648676-6	2016	TbL3+(I) spontaneously self-assembles into helical nanofibers (d = 6 nm) in water.	Water	76-81	transducin beta like 3	Homo sapiens	0-4
27305629-3	2016	Nuclear spin noise spectroscopy is used to monitor proton spin polarization buildup to thermal equilibrium of a mixture of glycerol, water, and copper oxide nanoparticles at 17.5 mK in a static magnetic field of 2.5 T. Relaxation times determined in such a way are essentially free from perturbations caused by excitation radiofrequency pulses, radiation damping, and insufficient excitation bandwidth.	Water	133-138	spindlin 1	Homo sapiens	8-12
27305629-3	2016	Nuclear spin noise spectroscopy is used to monitor proton spin polarization buildup to thermal equilibrium of a mixture of glycerol, water, and copper oxide nanoparticles at 17.5 mK in a static magnetic field of 2.5 T. Relaxation times determined in such a way are essentially free from perturbations caused by excitation radiofrequency pulses, radiation damping, and insufficient excitation bandwidth.	Water	133-138	spindlin 1	Homo sapiens	58-62
27321761-9	2016	Astrocytes of rats and sheep affected by ETX show overexpression of aquaporin-4, a membrane channel protein that is believed to help remove water from affected perivascular spaces in an attempt to resolve the perivascular edema.	Water	140-145	aquaporin-4	Ovis aries	68-79
26433375-1	2016	Aquaporin 4 (AQP4) is the major water channel expressed in the central nervous system (CNS), and it is primarily expressed in astrocytes.	Water	32-37	aquaporin 4	Homo sapiens	0-11
26433375-1	2016	Aquaporin 4 (AQP4) is the major water channel expressed in the central nervous system (CNS), and it is primarily expressed in astrocytes.	Water	32-37	aquaporin 4	Homo sapiens	13-17
27512016-3	2016	Two mutants having high PDH1pro:LUC2 expression and increased Pro accumulation at low water potential were found to be alleles of Cytochrome P450, Family 86, Subfamily A, Polypeptide2 (CYP86A2) and Long Chain Acyl Synthetase2 (LACS2), which catalyze two successive steps in very-long-chain fatty acid (VLCFA) synthesis.	Water	86-91	cytochrome P450, family 86, subfamily A, polypeptide 2	Arabidopsis thaliana	130-156
27512016-3	2016	Two mutants having high PDH1pro:LUC2 expression and increased Pro accumulation at low water potential were found to be alleles of Cytochrome P450, Family 86, Subfamily A, Polypeptide2 (CYP86A2) and Long Chain Acyl Synthetase2 (LACS2), which catalyze two successive steps in very-long-chain fatty acid (VLCFA) synthesis.	Water	86-91	cytochrome P450, family 86, subfamily A, polypeptide 2	Arabidopsis thaliana	171-183
27512016-3	2016	Two mutants having high PDH1pro:LUC2 expression and increased Pro accumulation at low water potential were found to be alleles of Cytochrome P450, Family 86, Subfamily A, Polypeptide2 (CYP86A2) and Long Chain Acyl Synthetase2 (LACS2), which catalyze two successive steps in very-long-chain fatty acid (VLCFA) synthesis.	Water	86-91	cytochrome P450, family 86, subfamily A, polypeptide 2	Arabidopsis thaliana	185-192
27344251-6	2016	The occurrence of phenylacetonitrile as an N-DBP in tap water was investigated for the first time; the results revealed that mug/L concentrations were present in nine different distributed drinking waters in China and the United States.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
27690011-2	2016	The predominant expression at the boundaries between cerebral parenchyma and major fluid compartments suggests the function of aquaporin-4 in water transfer into and out of the brain parenchyma.	Water	142-147	aquaporin 4	Mus musculus	127-138
27383795-0	2016	Effects of dissolved organic matter on phototransformation rates and dioxin products of triclosan and 2"-HO-BDE-28 in estuarine water.	Water	128-133	homeobox D13	Homo sapiens	108-111
27617999-1	2016	A water-soluble PdCl2(NH3)2/cationic 2,2"-bipyridyl system was found to be a highly efficient catalyst for Stille coupling of aryl iodides and bromides with organostannanes.	Water	2-7	phosducin like 2	Homo sapiens	16-21
29964757-3	2016	The results showed that the total concentrations of measured water-soluble ions were (15.39+-9.91), (21.10+-15.49) and (36.34+-18.51) mug m-3 in PM1.1, PM2.1 and PM9, respectively.	Water	61-66	transmembrane protein 11	Homo sapiens	145-148
29964757-4	2016	In PM1.1 and PM2.1, secondary water-soluble ions (SO42-, NO3- and NH4+) comprised 87.59% and 86.30% of all water-soluble ions, respectively, while in PM9, SO42- and Ca2+ comprised 32.78% and 28.54% of all water-soluble ions, respectively.	Water	30-35	transmembrane protein 11	Homo sapiens	3-6
29964757-4	2016	In PM1.1 and PM2.1, secondary water-soluble ions (SO42-, NO3- and NH4+) comprised 87.59% and 86.30% of all water-soluble ions, respectively, while in PM9, SO42- and Ca2+ comprised 32.78% and 28.54% of all water-soluble ions, respectively.	Water	107-112	transmembrane protein 11	Homo sapiens	3-6
29964757-4	2016	In PM1.1 and PM2.1, secondary water-soluble ions (SO42-, NO3- and NH4+) comprised 87.59% and 86.30% of all water-soluble ions, respectively, while in PM9, SO42- and Ca2+ comprised 32.78% and 28.54% of all water-soluble ions, respectively.	Water	107-112	transmembrane protein 11	Homo sapiens	3-6
27009472-1	2016	Bis-(2-ethylhexyl) phthalate (DEHP) is one of the most widely used plasticizers, and human beings are exposed to DEHP via polyvinyl chloride (PVC) materials, medical equipment and even drinking water.	Water	194-199	bis	Drosophila melanogaster	0-3
27307033-4	2016	Median and 95th percentiles of concentrations in tap water were in mug/L: Al: &lt;10, 48.3, As: 0.2, 2.1; B: &lt;100, 100; Ba: 30.7, 149.4; Ca: 85,000, 121,700; Cd: &lt;0.5, &lt;0.5; Ce: &lt;0.5, &lt;0.5; Co: &lt;0.5, 0.8; Cr: &lt;5, &lt;5; Cu: 70, 720; K: 2210, 6740; Fe: &lt;20, 46; Mn: &lt;5, &lt;5; Mo: &lt;0.5, 1.5; Na: 14,500, 66,800; Ni: &lt;2, 10.2; Mg: 6500, 21,200; Pb: &lt;1, 5.4; Sb: &lt;0.5, &lt;0.5; Se: &lt;1, 6.7; Sr: 256.9, 1004; Tl: &lt;0.5, &lt;0.5; U: &lt;0.5, 2.4; V: &lt;1, 1; Zn: 53, 208.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
27307033-6	2016	Since it is representative, this tap water contamination data can be used for integrated exposure assessment, in conjunction with diet and environmental (dust and soil) exposure data.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
27581320-1	2016	Aquaporin-4 (AQP4) channels play an important role in brain water homeostasis.	Water	60-65	aquaporin 4	Homo sapiens	0-11
27581320-1	2016	Aquaporin-4 (AQP4) channels play an important role in brain water homeostasis.	Water	60-65	aquaporin 4	Homo sapiens	13-17
27581320-3	2016	AQP4 channels are implicated in the pathophysiology of hydrocephalus, a disease of water imbalance that leads to CSF accumulation in the ventricular system.	Water	83-88	aquaporin 4	Homo sapiens	0-4
27598621-6	2016	Functional assays in oocytes showed that NIP4;1 and NIP4;2 transport water and nonionic solutes.	Water	69-74	NOD26-like intrinsic protein 4;1	Arabidopsis thaliana	41-47
27527337-0	2016	ZnO-Au-SnO2 Z-scheme photoanodes for remarkable photoelectrochemical water splitting.	Water	69-74	strawberry notch homolog 2	Homo sapiens	7-10
27934786-5	2016	The water contact angle decreased from 113  (for PCL) to 52  with increasing chitosan content.	Water	4-9	PHD finger protein 1	Homo sapiens	49-52
27931262-4	2016	Recently, the glymphatic system was described as a clearance system whereby CSF and ISF (interstitial fluid) is exchanged via the peri-arterial space and convective flow of ISF clearance is mediated by aquaporin 4 (AQP4), a water channel.	Water	224-229	aquaporin 4	Homo sapiens	202-213
27931262-4	2016	Recently, the glymphatic system was described as a clearance system whereby CSF and ISF (interstitial fluid) is exchanged via the peri-arterial space and convective flow of ISF clearance is mediated by aquaporin 4 (AQP4), a water channel.	Water	224-229	aquaporin 4	Homo sapiens	215-219
27941624-6	2016	In water, M1Q successfully demonstrated highly sensitive detection, showing a binding toward Hg2+ that was ~15 times stronger and a signal on/off ratio twice as high, compared to M1 in acetonitrile/water.	Water	3-8	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	93-96
27941624-7	2016	The thioacetal deprotection by Hg2+ ions was substantially facilitated in water without an organic cosolvent.	Water	74-79	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	31-34
27929406-0	2016	A Thin Film Nanocomposite Membrane with MCM-41 Silica Nanoparticles for Brackish Water Purification.	Water	81-86	methylmalonyl-CoA mutase	Homo sapiens	40-43
27929406-7	2016	With 0.02% MCM-41 silica NPs in the MPD solution, the water flux was increased from 44.0 to 64.1 L/m2 h, while the rejection virtually remained the same at 95% (2000 ppm NaCl saline solution, 25  C, 2068 kPa (300 psi)).	Water	54-59	methylmalonyl-CoA mutase	Homo sapiens	11-14
27422165-4	2016	AIM OF THE STUDY: This study aims to investigate the regulatory effect of the water extract of SP (WESP) and RA on efflux transports (ETs), including P-glycoprotein (p-gp), multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in HepG2 cell line.	Water	78-83	ATP binding cassette subfamily C member 2	Homo sapiens	173-214
27422165-4	2016	AIM OF THE STUDY: This study aims to investigate the regulatory effect of the water extract of SP (WESP) and RA on efflux transports (ETs), including P-glycoprotein (p-gp), multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in HepG2 cell line.	Water	78-83	ATP binding cassette subfamily C member 2	Homo sapiens	216-220
27809510-8	2016	Water efficiently protonates the basic N(Boc) (Bn) group to form a neutral HN(Boc) (Bn), which is easily removed.	Water	0-5	BOC cell adhesion associated, oncogene regulated	Homo sapiens	33-45
27704222-6	2016	We have observed that the addition of mainly Na+, K+, Rb+, NH4+, as well as Sr2+ and Ba2+ in water, shifts the equilibrium to the folded quadruplex form, whereby the NRAS sequence responds stronger than TERRA.	Water	93-98	NRAS proto-oncogene, GTPase	Homo sapiens	166-170
27751903-0	2016	Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation.	Water	71-76	aquaporin 4	Mus musculus	11-22
27751903-4	2016	Basal brain water content was increased in mice with a complete loss of aquaporin-4 (AQP4) water channels (global Aqp4-/- mice), but not in mice with a selective removal of perivascular AQP4 or in a novel mouse line with a selective deletion of ependymal AQP4 (Foxj1-Cre:Aqp4flox/flox mice).	Water	12-17	aquaporin 4	Mus musculus	72-83
27751903-4	2016	Basal brain water content was increased in mice with a complete loss of aquaporin-4 (AQP4) water channels (global Aqp4-/- mice), but not in mice with a selective removal of perivascular AQP4 or in a novel mouse line with a selective deletion of ependymal AQP4 (Foxj1-Cre:Aqp4flox/flox mice).	Water	12-17	aquaporin 4	Mus musculus	85-89
27751903-4	2016	Basal brain water content was increased in mice with a complete loss of aquaporin-4 (AQP4) water channels (global Aqp4-/- mice), but not in mice with a selective removal of perivascular AQP4 or in a novel mouse line with a selective deletion of ependymal AQP4 (Foxj1-Cre:Aqp4flox/flox mice).	Water	12-17	aquaporin 4	Mus musculus	114-118
27751903-4	2016	Basal brain water content was increased in mice with a complete loss of aquaporin-4 (AQP4) water channels (global Aqp4-/- mice), but not in mice with a selective removal of perivascular AQP4 or in a novel mouse line with a selective deletion of ependymal AQP4 (Foxj1-Cre:Aqp4flox/flox mice).	Water	91-96	aquaporin 4	Mus musculus	72-83
27751903-4	2016	Basal brain water content was increased in mice with a complete loss of aquaporin-4 (AQP4) water channels (global Aqp4-/- mice), but not in mice with a selective removal of perivascular AQP4 or in a novel mouse line with a selective deletion of ependymal AQP4 (Foxj1-Cre:Aqp4flox/flox mice).	Water	91-96	aquaporin 4	Mus musculus	85-89
27751903-6	2016	Our data suggest that water accumulates in brain when subpial AQP4 is missing, pointing to a critical role of this pool of water channels in brain water exit.	Water	22-27	aquaporin 4	Mus musculus	62-66
28070256-2	2016	The aim of this study was to assess the consumer perception of tap water quality and other drinking water sources in Gonabad as a small semiarid city.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
28070256-8	2016	Office employees, women and poor families had the most satisfaction from tap water quality.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
27809504-5	2016	Furthermore, modeling studies suggested that the binding interactions of this compound replace a structural water molecule reproducing its H-bonds in the MAGL binding site, thus identifying a new key anchoring point for the development of new MAGL inhibitors.	Water	108-113	monoglyceride lipase	Homo sapiens	154-158
27809504-5	2016	Furthermore, modeling studies suggested that the binding interactions of this compound replace a structural water molecule reproducing its H-bonds in the MAGL binding site, thus identifying a new key anchoring point for the development of new MAGL inhibitors.	Water	108-113	monoglyceride lipase	Homo sapiens	243-247
27834889-9	2016	Consequently, the water program aiming at providing 80% of rural people with access to tap water from a centralized piped system will not be possible.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	87-90
27990284-7	2016	SLA was formulated in an oil-in-water emulsion, producing an adjuvant that elicited potent Th1-biased adaptive responses.	Water	32-37	negative elongation factor complex member C/D	Homo sapiens	91-94
27494316-1	2016	We conducted chlorination, UV photolysis, and UV/chlorin reactions to investigate the intermediate formation and degradation mechanisms of geosmin and 2-methylisoborneol (2-MIB) in water.	Water	181-186	MIB E3 ubiquitin protein ligase 1	Homo sapiens	173-176
27591884-15	2016	In the water/sediment systems, from the first day, it degraded into B-1 in the sediment, and in the water mainly degraded into B-3.	Water	7-12	immunoglobulin kappa variable 4-1	Homo sapiens	127-130
27591884-15	2016	In the water/sediment systems, from the first day, it degraded into B-1 in the sediment, and in the water mainly degraded into B-3.	Water	100-105	immunoglobulin kappa variable 4-1	Homo sapiens	127-130
27607443-1	2016	2-Methylisoborneol (2-MIB) is a commonly detected cyanobacterial odorant in drinking water sources in many countries.	Water	85-90	MIB E3 ubiquitin protein ligase 1	Homo sapiens	22-25
27607443-2	2016	To provide safe and high-quality water, development of a monitoring method for the detection of 2-MIB-synthesis (mibC) genes is very important.	Water	33-38	MIB E3 ubiquitin protein ligase 1	Homo sapiens	98-101
27673276-2	2016	New theoretical treatment of spin interaction with the radio-frequency field and the simultaneously applied static non-uniform magnetic field provides the formula that match well with the measurement of restricted diffusion of water in pores of cement paste.	Water	227-232	spindlin 1	Homo sapiens	29-33
27785978-1	2016	AIM: This work spotlights on fabrication of CD44-tropic, layer-by-layer (LbL) coated, liquid crystalline nanoparticles of rapamycin (Rap-LbL-LCNPs) to enhance its water solubility and enable its anticancer use.	Water	163-168	CD44 molecule (Indian blood group)	Homo sapiens	44-48
27276181-12	2016	Having indoor tap water was protective (aOR: 0.65, 95% CI: 0.54-0.78), whereas a primary care giver who smoked was a risk factor (aOR: 5.15, 95% CI: 2.94-9.03).	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
27791155-3	2016	Here, we map the pathway for water and urea through the intestinal sodium/glucose cotransporter SGLT1.	Water	29-34	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	96-101
27791155-7	2016	The results demonstrate that water and urea follow the sugar transport pathway through SGLT1.	Water	29-34	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	87-92
27791155-10	2016	Water permeation through SGLT1 and other transporters bears directly on the structural mechanism for the transport of polar solutes through these proteins.	Water	0-5	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	25-30
27791155-11	2016	Finally, in vitro experiments on mouse small intestine show that SGLT1 accounts for two-thirds of the passive water flow across the gut.	Water	110-115	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	65-70
27788222-1	2016	The water-permeable channel aquaporin-4 (AQP4) is highly expressed in perivascular astrocytes of the mammalian brain and represents the major conduit for water across the blood-brain barrier.	Water	4-9	aquaporin 4	Homo sapiens	28-39
27788222-1	2016	The water-permeable channel aquaporin-4 (AQP4) is highly expressed in perivascular astrocytes of the mammalian brain and represents the major conduit for water across the blood-brain barrier.	Water	4-9	aquaporin 4	Homo sapiens	41-45
27788222-1	2016	The water-permeable channel aquaporin-4 (AQP4) is highly expressed in perivascular astrocytes of the mammalian brain and represents the major conduit for water across the blood-brain barrier.	Water	154-159	aquaporin 4	Homo sapiens	28-39
27788222-1	2016	The water-permeable channel aquaporin-4 (AQP4) is highly expressed in perivascular astrocytes of the mammalian brain and represents the major conduit for water across the blood-brain barrier.	Water	154-159	aquaporin 4	Homo sapiens	41-45
27650357-6	2016	Large enhancement of fluorescence was observed upon formation of 1:1 complexes of 1,4-DAT with water or methanol, which is explained in terms of an increased separation of interacting (n,pi*) and (pi,pi*) electronic states in the H-bonded complexes, and/or a suppression of the intersystem crossing process.	Water	95-100	solute carrier family 6 member 3	Homo sapiens	86-89
27790232-1	2016	The next advance in field crop productivity will likely need to come from improving crop use efficiency of resources (e.g., light, water, and nitrogen), aspects of which are closely linked with overall crop photosynthetic efficiency.	Water	131-136	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	26-30
27790232-1	2016	The next advance in field crop productivity will likely need to come from improving crop use efficiency of resources (e.g., light, water, and nitrogen), aspects of which are closely linked with overall crop photosynthetic efficiency.	Water	131-136	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	84-88
27789967-4	2016	METHODS: Free Ca2+ was measured with an ion-sensitive electrode in vitro in hard water (100-500 ppm, Ca2+) before and after addition of the cleanser and/or its components.	Water	81-86	carbonic anhydrase 2	Homo sapiens	14-17
27789967-5	2016	In an exploratory study, absorption of Ca2+ into skin from hard water was determined in three female participants (aged 21-29 years).	Water	64-69	carbonic anhydrase 2	Homo sapiens	39-42
27789967-8	2016	In the exploratory in vivo study, we measured a reduction of ~15% in free Ca2+ from simulated hard water over 10 minutes.	Water	99-104	carbonic anhydrase 2	Homo sapiens	74-77
27789967-9	2016	CONCLUSION: Baby cleansers can bind free Ca2+ and reduce the effective water hardness of bath water.	Water	71-76	carbonic anhydrase 2	Homo sapiens	41-44
27789967-9	2016	CONCLUSION: Baby cleansers can bind free Ca2+ and reduce the effective water hardness of bath water.	Water	94-99	carbonic anhydrase 2	Homo sapiens	41-44
27789967-10	2016	Reducing the amount of free Ca2+ in the water will reduce the availability of the ion for binding to the skin.	Water	40-45	carbonic anhydrase 2	Homo sapiens	28-31
27789967-11	2016	Altering or reducing free Ca2+ concentrations in bath water may be an important parameter in creating the ideal baby bath.	Water	54-59	carbonic anhydrase 2	Homo sapiens	26-29
27647193-14	2016	CONCLUSIONS: Hydrogen-rich water may improve serum AMH levels and reduce ovarian GC apoptosis in a mouse immune POF model induced by ZP3.	Water	27-32	zona pellucida glycoprotein 3	Mus musculus	133-136
27294385-3	2016	Aquaporin-7 (AQP7) is an aquaglyceroporin that facilitates glycerol and water transport.	Water	72-77	aquaporin 7	Rattus norvegicus	0-11
27294385-3	2016	Aquaporin-7 (AQP7) is an aquaglyceroporin that facilitates glycerol and water transport.	Water	72-77	aquaporin 7	Rattus norvegicus	13-17
27344242-6	2016	The combination of an UASB reactor and ceramic MBR is the most economical and feasible solution for water reclamation of mixed industrial wastewater.	Water	100-105	translocator protein	Homo sapiens	47-50
26992959-4	2016	Evidence based on the sweet water aftertastes of several novel sweetness inhibitors is presented providing new support for constitutive activity in T1R2/T1R3.	Water	28-33	taste 1 receptor member 2	Homo sapiens	148-152
27789884-0	2016	Synthesis of [H22 Zr5 WO4 10 P2O7]n 26n H2O by response surface methodology to adsorb Ca(II) in manganiferous wastewater.	Water	40-43	carbonic anhydrase 2	Homo sapiens	86-92
30641015-4	2016	Mice in the AHL control group drank tap water from ablactation till 7 months old.	Water	40-45	cadherin 23 (otocadherin)	Mus musculus	12-15
27669271-10	2016	Furthermore, in the experimental group (centuple ACE-containing water for seven days), beta2 nAChR expression decreased in many brain regions.	Water	64-69	hemoglobin, beta adult minor chain	Mus musculus	87-92
27722290-8	2016	Due to the presence of a net surface charge on lysozyme, electrostatic interactions in PIL-water systems and salt solutions enhanced lysozyme activity more than the specific hydrogen-bond interactions present in non-ionic molecular solvents.	Water	91-96	serpin family A member 2 (gene/pseudogene)	Homo sapiens	87-90
27599590-0	2016	Anti-inflammatory effects of Sanguisorbae Radix water extract on the suppression of mast cell degranulation and STAT-1/Jak-2 activation in BMMCs and HaCaT keratinocytes.	Water	48-53	signal transducer and activator of transcription 1	Homo sapiens	112-118
27383214-10	2016	Water bath immersion experiments also showed an important role of mechanical effects in the synergistic enhancement of TSL-mediated chemotherapy by ablative HIFU.	Water	0-5	TSL	Homo sapiens	119-122
27486675-0	2016	Influence of Water on the Interfacial Nanostructure and Wetting of [Rmim][NTf2] Ionic Liquids at Mica Surfaces.	Water	13-18	nuclear transport factor 2	Homo sapiens	74-78
27486675-3	2016	The interaction of the IL ions of [Rmim][NTf2] with water molecules through hydrogen bonding is suspected to disrupt IL ion layering and precursor film growth on mica.	Water	52-57	nuclear transport factor 2	Homo sapiens	41-45
27208489-6	2016	The Abeta+ACh rats were unimpaired in a striatal dependent visual discrimination task, but had impaired acquisition in the standard version of the Morris water task.	Water	154-159	amyloid beta precursor protein	Rattus norvegicus	4-9
27155358-1	2016	Astrocytes regulate extracellular glutamate and water homeostasis through the astrocyte-specific membrane proteins glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4), respectively.	Water	48-53	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	115-138
27155358-1	2016	Astrocytes regulate extracellular glutamate and water homeostasis through the astrocyte-specific membrane proteins glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4), respectively.	Water	48-53	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	140-144
27155358-1	2016	Astrocytes regulate extracellular glutamate and water homeostasis through the astrocyte-specific membrane proteins glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4), respectively.	Water	48-53	aquaporin 4	Mus musculus	150-161
27155358-1	2016	Astrocytes regulate extracellular glutamate and water homeostasis through the astrocyte-specific membrane proteins glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4), respectively.	Water	48-53	aquaporin 4	Mus musculus	163-167
25605447-0	2016	Relation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
25605447-2	2016	Elevated matrix metalloproteinase-9 (MMP-9) levels are also associated with these diseases, as well as with exposure to water As.	Water	120-125	matrix metallopeptidase 9	Homo sapiens	9-35
25605447-2	2016	Elevated matrix metalloproteinase-9 (MMP-9) levels are also associated with these diseases, as well as with exposure to water As.	Water	120-125	matrix metallopeptidase 9	Homo sapiens	37-42
27328404-2	2016	These water-in-oil-in-water DECs less than 200 nm in diameter are synthesized using a single component of PVA (polyvinyl alcohol) polymer and the magnetic nanoparticles, which are capable of encapsulating large quantities of targeted supermolecules composed of palitaxel-incorporated beta-cyclodextrin decorated by hyaluronic acid (HA, a CD44-targeting ligand) in the watery core.	Water	6-11	CD44 molecule (Indian blood group)	Homo sapiens	338-342
27328404-2	2016	These water-in-oil-in-water DECs less than 200 nm in diameter are synthesized using a single component of PVA (polyvinyl alcohol) polymer and the magnetic nanoparticles, which are capable of encapsulating large quantities of targeted supermolecules composed of palitaxel-incorporated beta-cyclodextrin decorated by hyaluronic acid (HA, a CD44-targeting ligand) in the watery core.	Water	22-27	CD44 molecule (Indian blood group)	Homo sapiens	338-342
27509294-2	2016	In addition to factors related to homeostasis of the inner ear, genetic factors have been implicated in its pathophysiology, including genes related to the transport of water and ionic composition maintenance of the endolymph, such as the aquaporin genes AQP2 and AQP3, and the potassium channel gene KCNE1.	Water	169-174	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	301-306
27333892-6	2016	However, the distribution of the water-soluble vs. adherent mucilage layers was significantly altered in irx7 compared to the WT.	Water	33-38	Exostosin family protein	Arabidopsis thaliana	105-109
27333892-7	2016	Both the amount of xylose and the extent of glycosyl linkages of xylan was dramatically decreased in irx7 water-soluble and adherent mucilage compared to the WT.	Water	106-111	Exostosin family protein	Arabidopsis thaliana	101-105
27333892-8	2016	The polymeric structure of water-soluble mucilage was altered in irx7, with a total loss of the higher molecular weight polymer components present in the WT.	Water	27-32	Exostosin family protein	Arabidopsis thaliana	65-69
27343607-6	2016	Finally, the sensor was successfully used to analyse the tap water, showing high potential for practical applications.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
27458983-5	2016	Concurrent density functional theory molecular modelling studies produced an energetic rationale for the unexpected [Zn(OAc)(H2 O)](+) coordination motif present in all of the Zn(2+) cross-bridged tetraazamacrocycle crystal structures, which differs from the chelating acetate [Zn(OAc)](+) structures of known unbridged and side-bridged tetraazamacrocyclic Zn(2+) -containing CXCR4 antagonists.	Water	125-130	C-X-C motif chemokine receptor 4	Homo sapiens	376-381
9528658-0	1998	1H-nuclear magnetic resonance evidence for acto-myosin-dependent structural changes of the intracellular water of frog skeletal muscle fiber.	Water	105-110	myosin heavy chain 14	Homo sapiens	48-54
9528658-5	1998	As the overlap between actin and myosin filaments is maximal in slack fibers and minimal in stretched fibers, these results indicate that the intracellular water located in the overlap region is less structured in rigor fibers than that in relaxed fibers.	Water	156-161	myosin heavy chain 14	Homo sapiens	33-39
9528658-6	1998	This suggests that the rigor crossbridge formation disrupts the structured water bound to myosin and actin filaments in muscle fiber.	Water	75-80	myosin heavy chain 14	Homo sapiens	90-96
9571643-12	1998	In the gastrointestinal system, NK1 receptors mediate smooth muscle contraction, regulate water and ion secretion and mediate neuro-neuronal communication.	Water	90-95	tachykinin receptor 1	Homo sapiens	32-35
10923422-0	1998	[Renal aquaporin-2 water channel expression in congestive heart failure rat].	Water	19-24	aquaporin 2	Rattus norvegicus	7-18
10923422-1	1998	OBJECTIVE: To study aquaporin-2 (AQP2) that mediates vasopressin-regulated collecting duct water permeability.	Water	91-96	aquaporin 2	Rattus norvegicus	20-31
10923422-1	1998	OBJECTIVE: To study aquaporin-2 (AQP2) that mediates vasopressin-regulated collecting duct water permeability.	Water	91-96	aquaporin 2	Rattus norvegicus	33-37
9442090-3	1998	Like its human and zibrafish counterparts, the mouse P450RAI cDNA catalyzes metabolism of retinoic acid into 4-OH-retinoic acid, 4-oxo-retinoic acid, 18-OH-retinoic acid, and unidentified water-soluble metabolites when transfected into COS-1 cells.	Water	188-193	cytochrome P450, family 26, subfamily a, polypeptide 1	Mus musculus	53-60
27238894-6	2016	Less fos activation in the amygdala was observed in both enriched groups following a water escape task whereas an increase in fos activation in the nucleus accumbens was observed in the natural-enriched animals.	Water	85-90	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	5-8
9889825-6	1998	These results may be explained as the intracellular water located in the overlap region between actin and myosin filaments is less structured in rigor state than that in relaxed state, or that the rigor formation disrupts the structured water bound to myofilaments.	Water	52-57	myosin heavy chain 14	Homo sapiens	106-112
27460349-4	2016	1 shows good catalytic activity and selectivity towards the hydrocarboxylation of cyclohexane to cyclohexanecarboxylic acid in water/acetonitrile or water/ionic liquid [BMPyr][NTf2] [BMPyr = 1-butyl-1 methylpyrrolidinium; NTf2 = bis(trifluoromethanesulfonyl)imide] medium.	Water	127-132	nuclear transport factor 2	Homo sapiens	176-180
27460349-4	2016	1 shows good catalytic activity and selectivity towards the hydrocarboxylation of cyclohexane to cyclohexanecarboxylic acid in water/acetonitrile or water/ionic liquid [BMPyr][NTf2] [BMPyr = 1-butyl-1 methylpyrrolidinium; NTf2 = bis(trifluoromethanesulfonyl)imide] medium.	Water	127-132	nuclear transport factor 2	Homo sapiens	222-226
27460349-4	2016	1 shows good catalytic activity and selectivity towards the hydrocarboxylation of cyclohexane to cyclohexanecarboxylic acid in water/acetonitrile or water/ionic liquid [BMPyr][NTf2] [BMPyr = 1-butyl-1 methylpyrrolidinium; NTf2 = bis(trifluoromethanesulfonyl)imide] medium.	Water	149-154	nuclear transport factor 2	Homo sapiens	176-180
27460349-4	2016	1 shows good catalytic activity and selectivity towards the hydrocarboxylation of cyclohexane to cyclohexanecarboxylic acid in water/acetonitrile or water/ionic liquid [BMPyr][NTf2] [BMPyr = 1-butyl-1 methylpyrrolidinium; NTf2 = bis(trifluoromethanesulfonyl)imide] medium.	Water	149-154	nuclear transport factor 2	Homo sapiens	222-226
9889825-6	1998	These results may be explained as the intracellular water located in the overlap region between actin and myosin filaments is less structured in rigor state than that in relaxed state, or that the rigor formation disrupts the structured water bound to myofilaments.	Water	237-242	myosin heavy chain 14	Homo sapiens	106-112
27571065-1	2016	The main water channel of the brain, aquaporin-4 (AQP4), is one of the classical water-specific aquaporins.	Water	9-14	aquaporin 4	Homo sapiens	37-48
9493562-18	1998	For example, leptin increases renal sodium and water excretion, apparently through a direct tubular action.	Water	47-52	leptin	Homo sapiens	13-19
27571065-1	2016	The main water channel of the brain, aquaporin-4 (AQP4), is one of the classical water-specific aquaporins.	Water	9-14	aquaporin 4	Homo sapiens	50-54
27571065-1	2016	The main water channel of the brain, aquaporin-4 (AQP4), is one of the classical water-specific aquaporins.	Water	81-86	aquaporin 4	Homo sapiens	37-48
29964716-7	2016	During the period of monitoring, the pCO2 and pCH4 in surface water were significantly correlated with pH, DO, chlorophyll a, TP, surface water temperature and water level.	Water	62-67	tRNA splicing endonuclease subunit 54	Homo sapiens	46-50
29964716-7	2016	During the period of monitoring, the pCO2 and pCH4 in surface water were significantly correlated with pH, DO, chlorophyll a, TP, surface water temperature and water level.	Water	138-143	tRNA splicing endonuclease subunit 54	Homo sapiens	46-50
29964716-7	2016	During the period of monitoring, the pCO2 and pCH4 in surface water were significantly correlated with pH, DO, chlorophyll a, TP, surface water temperature and water level.	Water	138-143	tRNA splicing endonuclease subunit 54	Homo sapiens	46-50
27571065-1	2016	The main water channel of the brain, aquaporin-4 (AQP4), is one of the classical water-specific aquaporins.	Water	81-86	aquaporin 4	Homo sapiens	50-54
10822612-6	1998	The model provides a quantitative description of the response to both the cross-linking following the addition of the b-Fab" and the competitive displacement of the hapten by a water-soluble small analyte.	Water	177-182	FA complementation group B	Homo sapiens	120-123
27571065-11	2016	Thus, a polarized expression of AQP4 as part of a control mechanism for a stable ionic environment and water balanced occurred at several locations in supporting and glial cells during evolution.	Water	103-108	aquaporin 4	Homo sapiens	32-36
27356908-0	2016	Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors.	Water	58-63	matrix metallopeptidase 12	Homo sapiens	72-99
27356908-4	2016	Among these glycoconjugates, a nanomolar MMP-12 inhibitor with improved water solubility, compound 3 [(R)-2-(N-(2-(3-(2-acetamido-2-deoxy-beta-d-glucopyranosyl)thioureido)ethyl)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid], was identified.	Water	72-77	matrix metallopeptidase 12	Homo sapiens	41-47
9371692-1	1997	In this work, we determined the effects of sphingosine 1-phosphate (S1P) on phospholipase D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn), and evaluated the effects of the water-soluble product ethanolamine on S1P-induced DNA synthesis in NIH 3T3 cells.	Water	189-194	sphingosine-1-phosphate receptor 1	Mus musculus	68-71
27485513-10	2016	RESULTS: Both natural and tap water sources were contaminated with FLA, Cryptosporidium spp.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
27232763-2	2016	We validated the force-field by calculating the radii of gyration of two poloxamers, P85 and P188, solvated in water and by considering the poloxamer density distributions at the air/water interface.	Water	111-116	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	85-88
27529222-2	2016	Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema.	Water	40-45	aquaporin 4	Homo sapiens	0-11
9473738-5	1997	ESR spin trapping with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) showed hydroxy radical (OH) generation in the reaction of H2O2 with either Cu,Zn-SOD or ceruloplasmin.	Water	70-85	ceruloplasmin	Homo sapiens	151-164
27529222-2	2016	Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema.	Water	40-45	aquaporin 4	Homo sapiens	13-17
27186686-0	2016	Prediction of powdered activated carbon doses for 2-MIB removal in drinking water treatment using a simplified HSDM approach.	Water	76-81	MIB E3 ubiquitin protein ligase 1	Homo sapiens	52-55
26607275-2	2016	Balneotherapy-also called mineral baths or spa therapy-uses different types of mineral water compositions like sulphur, radon, carbon dioxin, etc.	Water	87-92	surfactant protein A2	Homo sapiens	43-46
9369468-0	1997	Mercury-sensitive residues and pore site in AQP3 water channel.	Water	49-54	aquaporin 3 (Gill blood group)	Homo sapiens	44-48
26059709-1	2016	Irrigating wounds with tap water does not increase colonisation, but controlled studies are required for further evidence.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
26059709-9	2016	It is concluded that skin wound irrigation with tap water leads to further reduction of Gram-positive bacteria compared with 0 9% sodium chloride sterile solution, with no difference in colonisation of haemolytic bacteria, Gram-negative bacteria and fungi.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
27517922-3	2016	Aquaporin-4 (AQP4), a membrane-bound protein that regulates water permeability is a member of the aquaporin family of water channel proteins that is expressed in the endfeet of astrocytes in the central nervous system (CNS).	Water	60-65	aquaporin 4	Mus musculus	0-11
27517922-3	2016	Aquaporin-4 (AQP4), a membrane-bound protein that regulates water permeability is a member of the aquaporin family of water channel proteins that is expressed in the endfeet of astrocytes in the central nervous system (CNS).	Water	60-65	aquaporin 4	Mus musculus	13-17
9369468-15	1997	These results suggest that the structure of the aqueous pore of AQP3 resembles those of AQP1 and AQP2 and support the hypothesis that water and small molecules share a common pore in AQP3.	Water	134-139	aquaporin 3 (Gill blood group)	Homo sapiens	64-68
27497563-14	2016	The overall picture shows a remarkable similarity with the corresponding one for the ST2 water model, for which the existence of a LLCP has been demonstrated in recent years.	Water	89-94	ST2	Homo sapiens	85-88
27252474-0	2016	Nax signaling evoked by an increase in [Na+] in CSF induces water intake via EET-mediated TRPV4 activation.	Water	60-65	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	48-51
9369468-15	1997	These results suggest that the structure of the aqueous pore of AQP3 resembles those of AQP1 and AQP2 and support the hypothesis that water and small molecules share a common pore in AQP3.	Water	134-139	aquaporin 2	Homo sapiens	97-101
9369468-15	1997	These results suggest that the structure of the aqueous pore of AQP3 resembles those of AQP1 and AQP2 and support the hypothesis that water and small molecules share a common pore in AQP3.	Water	134-139	aquaporin 3 (Gill blood group)	Homo sapiens	183-187
9366573-8	1997	PK-G I suppression was also observed in vivo in rats given isosorbide dinitrate in the drinking water, with a dose-dependent suppression of PK-G I protein in the aorta.	Water	96-101	protein kinase cGMP-dependent 1	Rattus norvegicus	0-6
27444184-0	2016	Preliminary human health risk assessment of arsenic and fluoride in tap water from Zacatecas, Mexico.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
27456139-1	2016	This study investigated the effectiveness of coating and suspension of Degussa P25 TiO2 photocatalyst to remove natural organic matter (NOM) from surface water for use as power plant feedwater.	Water	154-159	tubulin polymerization promoting protein	Homo sapiens	79-82
9394673-2	1997	MATERIAL AND METHODS: The T1 and T2 relaxation times of bone-marrow water in the L1-3 vertebrae of 20 healthy individuals were measured by MR imaging with a 1.5 T magnet.	Water	68-73	immunoglobulin kappa variable 2-4 (pseudogene)	Homo sapiens	81-85
27469628-0	2016	Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis.	Water	87-92	Trehalase	Drosophila melanogaster	39-43
27470199-3	2016	We thus call this state spin slush, in analogy to the heterogeneous mixture of solid and liquid water.	Water	96-101	spindlin 1	Homo sapiens	24-28
27402760-0	2016	AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption.	Water	85-90	A kinase (PRKA) anchor protein 11	Mus musculus	0-7
27089850-0	2016	Free-water and BOLD imaging changes in Parkinson"s disease patients chronically treated with a MAO-B inhibitor.	Water	5-10	monoamine oxidase B	Homo sapiens	95-100
9370466-0	1997	Water-coupled low-frequency modes of myoglobin and lysozyme observed by inelastic neutron scattering.	Water	0-5	myoglobin	Homo sapiens	37-46
26990369-2	2016	Despite bacterial contamination in rinse bottles and reports of infections from contaminated irrigation water, tap water is still used by ~50% of irrigation users, raising a potential public health concern.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
9365934-2	1997	The models develop a structural rationale for the discovery of the recently described highly potent peptidomimetic NK1 antagonists S18523 and S19752 which were designed to be water soluble.	Water	175-180	tachykinin receptor 1	Homo sapiens	115-118
26990369-9	2016	There was a trend toward tap having more bacteria than distilled water.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	25-28
27419322-0	2016	Choosing Tap Water vs. Sterile Saline for Wound Irrigation.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
9365934-3	1997	Water solubility was conferred on these compounds by introduction of an anionic butyl-tetrazole substituent on the scaffold of dipeptide-derived NK1 antagonist analogues.	Water	0-5	tachykinin receptor 1	Homo sapiens	145-148
27508036-0	2016	Effects of immobilizations stress with or without water immersion on the expression of atrial natriuretic peptide in the hearts of two rat strains.	Water	50-55	natriuretic peptide A	Rattus norvegicus	87-113
9302264-0	1997	Identification and characterization of aquaporin-2 water channel mutations causing nephrogenic diabetes insipidus with partial vasopressin response.	Water	51-56	aquaporin 2	Homo sapiens	39-50
27130898-6	2016	Treatment of intracerebroventricular Abeta oligomer infusion AD model rats with NMN (500mg/kg, intraperitoneally) sustained improvement in cognitive function as assessed by the Morris water maze.	Water	184-189	amyloid beta precursor protein	Rattus norvegicus	37-42
27208702-5	2016	Changes in atrial volume induced by increased atrial pressure from o to 1, 2, 4, or 6cm H2O caused proportional increases in mechanically-stimulated extracellular fluid (ECF) translocation and stretch-activated ANP secretion.	Water	88-91	natriuretic peptide A	Rattus norvegicus	211-214
9302264-6	1997	Residue Cys181 in AQP2 is the site for inhibition of water permeation by mercurial compounds and is located near to the NPA motif conserved in all aquaporins.	Water	53-58	aquaporin 2	Homo sapiens	18-22
27410737-1	2016	Aquaporin-4 (AQP4), the primary water channel in glial cells of the mammalian brain, plays a critical role in water transport in the central nervous system.	Water	32-37	aquaporin 4	Homo sapiens	0-11
27347731-0	2016	Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.	Water	129-134	monoamine oxidase B	Homo sapiens	79-98
27410737-1	2016	Aquaporin-4 (AQP4), the primary water channel in glial cells of the mammalian brain, plays a critical role in water transport in the central nervous system.	Water	32-37	aquaporin 4	Homo sapiens	13-17
9302264-10	1997	Water permeability assays showed a high Pf in cells expressing wild-type and L22V AQP2.	Water	0-5	aquaporin 2	Homo sapiens	82-86
27410737-1	2016	Aquaporin-4 (AQP4), the primary water channel in glial cells of the mammalian brain, plays a critical role in water transport in the central nervous system.	Water	110-115	aquaporin 4	Homo sapiens	0-11
9415040-2	1997	The purpose of this work was to analyse the generation of MCP-1 and mRNA transcript in a model of chronic inflammation using a granulomatous tissue induced by potassium permanganate (KMnO4; water soluble crystals).	Water	190-195	C-C motif chemokine ligand 2	Rattus norvegicus	58-63
27410737-1	2016	Aquaporin-4 (AQP4), the primary water channel in glial cells of the mammalian brain, plays a critical role in water transport in the central nervous system.	Water	110-115	aquaporin 4	Homo sapiens	13-17
27410737-2	2016	Previous experiments have shown that the water permeability of AQP4 depends on the cholesterol content in the lipid bilayer, but it was not clear whether changes in permeability were due to direct cholesterol-AQP4 interactions or to indirect effects caused by cholesterol-induced changes in bilayer elasticity or bilayer thickness.	Water	41-46	aquaporin 4	Homo sapiens	63-67
27410737-9	2016	These structural changes, caused by mismatch between the hydrophobic length of AQP4 and the bilayer hydrocarbon thickness, could explain the observed differences in water permeability with changes in bilayer thickness.	Water	165-170	aquaporin 4	Homo sapiens	79-83
27471383-2	2016	Water-dispersible and light-sensitive NiO core was synthesized with folic acid (FA) connected bovine serum albumin (BSA) shell on entrapped doxorubicin (DOX).	Water	0-5	albumin	Sus scrofa	101-114
27295276-0	2016	Proton-Induced Trap States, Injection and Recombination Dynamics in Water-Splitting Dye-Sensitized Photoelectrochemical Cells.	Water	68-73	TRAP	Homo sapiens	15-19
27142778-9	2016	Moreover, the assembly of AtPIP2;1 tetramers is critical for their trafficking from the ER to the plasma membrane, as well as water permeability.	Water	126-131	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	26-34
9335376-0	1997	Aquaporin-2 transfection of Madin-Darby canine kidney cells reconstitutes vasopressin-regulated transcellular osmotic water transport.	Water	118-123	aquaporin 2	Canis lupus familiaris	0-11
27344558-6	2016	The typical oestrogen, 17beta-estradiol (17beta-E2), was detected above the method limit of quantification (m-LOQ) in 5 of 14 analysed tap water samples at concentrations from 0.09 to 0.15 ng L(-1).	Water	139-144	nuclear RNA export factor 1	Homo sapiens	135-138
9335376-1	1997	Water transport across the mammalian collecting tubule is regulated by vasopressin-dependent aquaporin-2 insertion into and retrieval from the apical cell membrane.	Water	0-5	aquaporin 2	Canis lupus familiaris	93-104
27124361-0	2016	Progressive Increase in Disinfection Byproducts and Mutagenicity from Source to Tap to Swimming Pool and Spa Water: Impact of Human Inputs.	Water	109-114	surfactant protein A2	Homo sapiens	105-108
9335377-10	1997	Dehydration and dDAVP stimulated translocation of AQP-2 from intracellular vesicles to the plasma membrane, whereas water loading caused a shift of AQP-2 channels back to intracellular vesicles in both adult and immature animals.	Water	116-121	aquaporin 2	Rattus norvegicus	148-153
26916786-6	2016	The water contact angle of PCL scaffolds decreased from 141.4 +- 3.8 to 118.4 +- 7.6 in the presence of CSMs.	Water	4-9	PHD finger protein 1	Homo sapiens	27-30
9335377-11	1997	In summary, AQP-2 expression and trafficking in the immature kidney is appropriately stimulated by water deprivation and dDAVP.	Water	99-104	aquaporin 2	Rattus norvegicus	12-17
9432898-10	1997	Manual FVL with inhalation P no more than 10 cm H2O completely prevented the entry of gas narcotic mixture into the stomach.	Water	48-51	coagulation factor V	Homo sapiens	7-10
27085409-6	2016	The concentration of nonstructural carbohydrates (water-soluble carbohydrates plus starch) was numerically greater in the p.m.- versus the a.m.-cut TIM and averaged 13.2+-1.06% and 12.2+-1.13%, respectively.	Water	50-55	triosephosphate isomerase 1	Bos taurus	148-151
27135698-11	2016	To the best of our knowledge, this is the first comprehensive investigation of indirect photolysis of BDE-153 in water containing NOM.	Water	113-118	homeobox D13	Homo sapiens	102-105
28058090-1	2016	While the problem of unsafe tap water in Flint, Michigan fueled outrage and better awareness in regard to the hazards of lead in tap water, the problem has existed in city after city for years in the US and in other countries.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
26849413-12	2016	In vivo metformin (100 mg/Kg) in drinking water for 60 days induced Abcd2 levels and mitochondrial oxidative phosphorylation protein levels in the brain and spinal cord of Abcd1-KO mice.	Water	42-47	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	172-177
9322991-11	1997	Leptin in high doses increases renal sodium and water excretion, apparently through a direct tubular action.	Water	48-53	leptin	Homo sapiens	0-6
27371173-1	2016	BACKGROUND: The discovery of a highly specific antibody against the aquaporin-4 (AQP4) water channel (AQP4-IgG) unified the spectrum of neuromyelitis optica spectrum disorders (NMOSD), which are considered to be antibody-mediated autoimmune diseases.	Water	87-92	aquaporin 4	Homo sapiens	68-79
27371173-1	2016	BACKGROUND: The discovery of a highly specific antibody against the aquaporin-4 (AQP4) water channel (AQP4-IgG) unified the spectrum of neuromyelitis optica spectrum disorders (NMOSD), which are considered to be antibody-mediated autoimmune diseases.	Water	87-92	aquaporin 4	Homo sapiens	81-85
27371173-1	2016	BACKGROUND: The discovery of a highly specific antibody against the aquaporin-4 (AQP4) water channel (AQP4-IgG) unified the spectrum of neuromyelitis optica spectrum disorders (NMOSD), which are considered to be antibody-mediated autoimmune diseases.	Water	87-92	aquaporin 4	Homo sapiens	102-106
27595820-3	2016	Blocking this pathway with a selective antagonist of glucagon-like peptide-1 receptors slowed down the elimination of excessive water from the body.	Water	128-133	glucagon	Rattus norvegicus	53-76
9310837-1	1997	Based on molecular dynamics simulations, it is proposed that water within the binding groove of the human MHC class I molecule HLA-A2 plays a role in the formation of its complex with the influenza matrix protein (residues 58-66; GILGFVFTL) peptide.	Water	61-66	major histocompatibility complex, class I, B	Homo sapiens	106-126
26987760-6	2016	The absorbed water in the PIL gel is desorbed by moderate heating via the LCST behavior, and the absolute absorption/desorption amount is improved by copolymerization of [P555VB ]Cl with more hydrophilic [P444VB ]Cl monomer.	Water	13-18	serpin family A member 2 (gene/pseudogene)	Homo sapiens	26-29
26991998-4	2016	Self-assembly of the amphiphilic PVEtImBr-b-PVOcImBr block copolymer, i.e., of PIL-b-PIL-type, rapidly takes place in water, forming polymer nanoparticles consisting of a hydrophilic PVEtImBr corona and a hydrophobic PVOcImBr core.	Water	118-123	methionine sulfoxide reductase B2	Homo sapiens	79-84
9309208-0	1997	Comparison of the water transporting properties of MIP and AQP1.	Water	18-23	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	59-63
9309208-7	1997	Water transport by MIP had a higher activation energy (approximately 7 Kcal/ mole) than water transport by AQP1 (approximately 2.5 Kcal/Mole) but a substantially lower activation energy than water flux across bare oolemma (approximately 20 Kcal/mole).	Water	88-93	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	107-111
9309208-8	1997	Though the water-transport properties of MIP and AQP1 differ quantitatively, they are qualitatively quite similar.	Water	11-16	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	49-53
9326761-8	1997	Intrathymic injection of S-Ag reduced the incidence of EAU in animals subsequently immunized with S-Ag and pertussis, and prevented it entirely in rats immunized in the absence of pertussis.	Water	55-58	S-antigen visual arrestin	Rattus norvegicus	25-29
27359350-6	2016	On October 16, 2015, the Flint water source was switched back to DWA, and residents were instructed to use filtered tap water for cooking and drinking.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
27359350-12	2016	Although unrelated to lead in the water, the water advisory likely reduced tap water consumption and increased consumption of bottled water.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	75-78
27359350-12	2016	Although unrelated to lead in the water, the water advisory likely reduced tap water consumption and increased consumption of bottled water.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	75-78
27359350-12	2016	Although unrelated to lead in the water, the water advisory likely reduced tap water consumption and increased consumption of bottled water.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	75-78
27154707-0	2016	Paper-based analytical device for sampling, on-site preconcentration and detection of ppb lead in water.	Water	98-103	histatin 1	Homo sapiens	86-89
9326761-11	1997	These data demonstrate that intrathymic S-Ag injection can be an effective method for protection from EAU, apparently through the induction of immunological tolerance and not active suppression.	Water	102-105	S-antigen visual arrestin	Rattus norvegicus	40-44
9261056-2	1997	The aquaporin-2 water channel has been demonstrated to be the target for this action of vasopressin.	Water	16-21	aquaporin 2	Homo sapiens	4-15
27107142-0	2016	The occurrence of haloanisoles as an emerging odorant in municipal tap water of typical cities in China.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
27107142-1	2016	In this study, occurrence of the haloanisoles odorous compounds in tap water of Chinese cities, were investigated by solid-phase microextraction (SPME)-GC/MS analysis.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
27107142-8	2016	Based on the survey of occurrence of halophenol and residual chlorine, the possible source for the formation of haloanisoles in tap water was discussed.	Water	132-137	nuclear RNA export factor 1	Homo sapiens	128-131
9680320-1	1997	Electron-microscopic examination of water samples from the hypersaline Dead Sea showed the presence of high numbers of virus-like particles.	Water	36-41	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
27441087-2	2016	However, crop plants selected by humans to yield products such as grain, vegetable, or fruit in favorable environments with high inputs of water and fertilizer are expected to yield an economic product in response to inputs.	Water	139-144	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	9-13
9263686-2	1997	Aquaporin-2, "vasopressin-regulated water channel", is regulated by vasopressin in two ways to account for overall control of collecting duct water permeability.	Water	36-41	aquaporin 2	Homo sapiens	0-11
27462134-1	2016	Aquaporin-4 (AQP4) is a selective water channel that is located on the plasma membrane of myofibers in skeletal muscle and is bound to alpha1-syntrophin.	Water	34-39	aquaporin 4	Homo sapiens	0-11
27462134-1	2016	Aquaporin-4 (AQP4) is a selective water channel that is located on the plasma membrane of myofibers in skeletal muscle and is bound to alpha1-syntrophin.	Water	34-39	aquaporin 4	Homo sapiens	13-17
27462134-2	2016	It is considered that AQP4 is involved in the modulation of homeostasis in myofibers through the regulation of water transport and osmotic pressure.	Water	111-116	aquaporin 4	Homo sapiens	22-26
27462134-6	2016	The present study suggests that AQP4 may regulate the efficiency of water transport in hypertrophied myofibers through its interaction with alpha1-syntrophin.	Water	68-73	aquaporin 4	Homo sapiens	32-36
9263686-3	1997	First, vasopressin has a short-term effect in triggering translocation of aquaporin-2-containing intracytoplasmic vesicles to the apical plasma membrane, thus increasing principal cell water permeability.	Water	185-190	aquaporin 2	Homo sapiens	74-85
9263686-4	1997	Second, vasopressin has a long-term effect in increasing the abundance of aquaporin-2 in collecting duct principal cells, increasing the maximal attainable water permeability.	Water	156-161	aquaporin 2	Homo sapiens	74-85
27353625-0	2016	Handwashing With a Water-Efficient Tap and Low-Cost Foaming Soap: The Povu Poa "Cool Foam" System in Kenya.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	35-38
9177353-3	1997	Expression in Xenopus oocytes and functional studies of an erythrocyte integral membrane protein of relative molecular mass 28,000, identified it as the mercury-sensitive water channel, aquaporin-1 (AQP1).	Water	171-176	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	186-197
27379020-8	2016	These conformational differences result in a larger tilt-angle of the membrane-embedded helix in IGF1R in comparison to IR to compensate for interactions with water molecules at the membrane-solvent interfaces.	Water	159-164	insulin like growth factor 1 receptor	Homo sapiens	97-102
9177353-3	1997	Expression in Xenopus oocytes and functional studies of an erythrocyte integral membrane protein of relative molecular mass 28,000, identified it as the mercury-sensitive water channel, aquaporin-1 (AQP1).	Water	171-176	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	199-203
9815766-0	1997	Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.	Water	80-85	thymidylate synthetase	Homo sapiens	147-167
26868560-4	2016	The residual levels decreased following washing with stagnant, running, and stagnant+running tap water (i.e., decline in levels increased from 65.08% to 85.02%, 69.99 to 86.79, and 74.75 to 88.96, respectively).	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
26868560-7	2016	Additionally, washing with stagnant and running tap water or even stagnant water for 5 min might reduce the residue levels substantially, making the prepared food safe for human consumption.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
27139895-2	2016	The relative water stability of the studied MOFs is in the order HKUST-1 &gt; MOF-505 ~ UMCM-150 &gt; NOTT-101 &gt; DUT-23(Cu) &gt; [Zn2(BPnDC)2(DABCO)] ~ [Cu3(TPTrC)2(DABCO)] &gt; MOF-5.	Water	13-18	deoxyuridine triphosphatase	Homo sapiens	116-119
9815766-1	1997	ZD9331 is a drug that was developed from a potent class of water-soluble, C7-methyl-substituted, quinazoline-based inhibitors of thymidylate synthase (TS) that are transported into cells via a saturable, carrier-mediated system (reduced folate carrier, or RFC) but are not substrates for folylpolyglutamate synthetase.	Water	59-64	thymidylate synthetase	Homo sapiens	129-149
9241694-3	1997	A levelling bulb with water mounted on the pen transmits the pressure adjustments to the KOH solution through a water filled tubing.	Water	22-27	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	43-46
26183039-0	2016	Has irrigated water from Mahaweli River contributed to the kidney disease of uncertain etiology in the dry zone of Sri Lanka?	Water	14-19	sorcin	Homo sapiens	115-118
26183039-1	2016	The Mahaweli is the largest river basin in Sri Lanka that provides water to the dry zone region through multipurpose irrigation schemes .	Water	67-72	sorcin	Homo sapiens	43-46
9241694-3	1997	A levelling bulb with water mounted on the pen transmits the pressure adjustments to the KOH solution through a water filled tubing.	Water	112-117	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	43-46
9129801-5	1997	The bovine rhodopsin model thus determined is closely packed, but has a few small polar cavities, presumably filled by water, and has a binding pocket that is complementary to 11-cis (6-s-cis, 12-s-trans, C = N anti)-retinal or to all-trans-retinal, depending on conformations of the Lys296 and Trp265 side chains.	Water	119-124	rhodopsin	Bos taurus	11-20
26399884-8	2016	Micronuclei formation tests show that well water and tap water in these regions have no mutagenicity.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
27030736-4	2016	Two weeks later, acute injection of clozapine N-oxide (CNO) produced dose-dependent increases in water intake of mice with DREADD expression in the SFO.	Water	97-102	biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino	Mus musculus	36-53
9129806-0	1997	Molecular dynamics simulations of Leu-enkephalin in water and DMSO.	Water	52-57	prodynorphin	Homo sapiens	34-48
9218359-0	1997	Persistence of MS-2 and PRD-1 bacteriophages in an ultrapure water system.	Water	61-66	MS2	Homo sapiens	15-19
26863260-13	2016	Moreover, inhibition of PAK1 by IPA-3 reduced spinal cord water content and Evans blue extravasation, increased neuronal survival, and reduced TUNEL-positive cells at 24 hours after SCI.	Water	58-63	p21 (RAC1) activated kinase 1	Mus musculus	24-28
9218359-4	1997	Inactivation of MS-2 was dependent on water quality and pH.	Water	38-43	MS2	Homo sapiens	16-20
27230915-10	2016	Concentration of arsenic in home tap water and estimated water consumption were strongly predictive of levels of arsenicals in urine as were smoking, body mass index, and gender.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
9109429-8	1997	The results suggest that escape from vasopressin-induced antidiuresis is attributable, at least in part, to a vasopressin-independent decrease in aquaporin-2 water channel expression in the renal collecting duct.	Water	158-163	aquaporin 2	Rattus norvegicus	146-157
27196718-2	2016	* This observance highlights ways that swimmers; parents of young swimmers; aquatic facility operators; residential pool, hot tub, or spa owners; beach managers; and public health officials can maximize the health benefits of water-based physical activity while minimizing the risk for recreational water-associated illness and injury.	Water	226-231	surfactant protein A2	Homo sapiens	134-137
27196718-2	2016	* This observance highlights ways that swimmers; parents of young swimmers; aquatic facility operators; residential pool, hot tub, or spa owners; beach managers; and public health officials can maximize the health benefits of water-based physical activity while minimizing the risk for recreational water-associated illness and injury.	Water	299-304	surfactant protein A2	Homo sapiens	134-137
27417861-2	2016	Since 2014, Flint citizens-among the poorest in America, mostly African American-had complained that their tap water was foul and discolored.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
9126662-1	1997	Hemodynamic changes associated with the lowering of total cholesterol (TC) by the water-soluble HMG-COA reductase inhibitor pravastatin were investigated in 59 patients with hypercholesterolemia (TC level at least 220 mg/dl) who received pravastatin therapy for 6 months.	Water	82-87	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	96-113
27179860-14	2016	As the SCS increased beyond 3, we observed a progressive quadratic decrease of the water retained in the curd (%CYWATER), which caused a parallel decrease in %CYCURD.	Water	83-88	SCS	Bos taurus	7-10
27149014-0	2016	Molecular Mechanisms of Spin Crossover in the {Fe(pz)[Pt(CN)4]} Metal-Organic Framework upon Water Adsorption.	Water	93-98	spindlin 1	Homo sapiens	24-28
27149014-2	2016	In this study, molecular dynamics simulations using ligand-field molecular mechanics are performed to elucidate, for the first time, the molecular mechanisms responsible for the variation of the spin-crossover properties of the {Fe(pz)[Pt(CN)4]} metal-organic framework upon water adsorption.	Water	275-280	spindlin 1	Homo sapiens	195-199
27149014-3	2016	The simulations demonstrate a direct relationship between the water loading adsorbed in the pores and the variation of the spin-crossover transition temperature, with the high-spin state of the material becoming gradually more stabilized as the number of adsorbed water molecules increases.	Water	62-67	spindlin 1	Homo sapiens	123-127
27149014-3	2016	The simulations demonstrate a direct relationship between the water loading adsorbed in the pores and the variation of the spin-crossover transition temperature, with the high-spin state of the material becoming gradually more stabilized as the number of adsorbed water molecules increases.	Water	62-67	spindlin 1	Homo sapiens	176-180
9138553-5	1997	delta Nw is the difference in the number of PEG-inaccessible water molecules between the glucose-bound and glucose-free conformations of hexokinase.	Water	61-66	hexokinase	Saccharomyces cerevisiae S288C	137-147
27149014-3	2016	The simulations demonstrate a direct relationship between the water loading adsorbed in the pores and the variation of the spin-crossover transition temperature, with the high-spin state of the material becoming gradually more stabilized as the number of adsorbed water molecules increases.	Water	264-269	spindlin 1	Homo sapiens	123-127
27149014-3	2016	The simulations demonstrate a direct relationship between the water loading adsorbed in the pores and the variation of the spin-crossover transition temperature, with the high-spin state of the material becoming gradually more stabilized as the number of adsorbed water molecules increases.	Water	264-269	spindlin 1	Homo sapiens	176-180
27149014-4	2016	The decrease of the spin-crossover temperature of {Fe(pz)[Pt(CN)4]} upon water adsorption predicted by the simulations is in agreement with the available experimental data and is traced back to the elongation of the bonds between the Fe(II) atoms and the organic linkers induced by interactions of the adsorbed water molecules with the framework.	Water	73-78	spindlin 1	Homo sapiens	20-24
27149014-4	2016	The decrease of the spin-crossover temperature of {Fe(pz)[Pt(CN)4]} upon water adsorption predicted by the simulations is in agreement with the available experimental data and is traced back to the elongation of the bonds between the Fe(II) atoms and the organic linkers induced by interactions of the adsorbed water molecules with the framework.	Water	311-316	spindlin 1	Homo sapiens	20-24
27117780-17	2016	Using tap water to store RGP lenses and topping off solution in the lens case were modifiable risk behaviors identified in RGP wearers who wore lenses for both orthokeratology and nonorthokeratology indications.	Water	10-15	nuclear RNA export factor 1	Homo sapiens	6-9
27017073-6	2016	Liquid water content (LWC) in both PM1 and PM2.5 had positive correlations with relative humidity (RH) but negative correlations with visibility, implying that hygroscopic growth might be a factor for visibility impairment, especially LWC in PM1.	Water	7-12	transmembrane protein 11	Homo sapiens	35-38
27167070-4	2016	Here we show that menadione (a water-soluble analog of vitamin K3) inhibits BP-induced expression and enzymatic activity of both CYP1A1 and CYP1A2 in vivo (in the rat liver) and BP-induced activity of CYP1A1 in vitro.	Water	31-36	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	140-146
9133606-0	1997	Intramembrane signaling mediated by hydrogen-bonding of water and carboxyl groups in bacteriorhodopsin and rhodopsin.	Water	56-61	rhodopsin	Bos taurus	93-102
9133606-6	1997	Similar interactions, through internal water molecules and the peptide bonds in helices B and C, take place in bovine rhodopsin.	Water	39-44	rhodopsin	Bos taurus	118-127
9049456-10	1997	Serum beta 2-microglobulin concentrations decreased with the NaHCO3-containing water.	Water	79-84	beta-2-microglobulin	Homo sapiens	6-26
26998586-3	2016	The conjugation of the Pd/L2 system and the water addition protocol can efficiently catalyze a broad range of electron-rich, -neutral, -deficient, and sterically hindered aryl chlorides and heteroaryl chlorides with excellent yields within three hours and the catalyst loading can be down to 0.05 mol % Pd for the first time.	Water	44-49	programmed cell death 1 ligand 2	Homo sapiens	23-28
27164108-5	2016	The proposed method was finally used to determine HZ in tap water to simulate the analysis of real samples.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
25342669-8	2016	SOX deficiency was established by feeding rats with low molybdenum (Mo) diet and adding 200 ppm tungsten (W) to their drinking water.	Water	127-132	sulfite oxidase	Rattus norvegicus	0-3
27446930-1	2016	Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial methylmalonyl-CoA mutase (MCM).	Water	54-59	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	122-141
9176054-9	1997	In the lens, the major water channel is AQP1 with detectable levels of AQP4 and AQP5 that are approximately 1000-fold lower than AQP1.	Water	23-28	aquaporin 4	Rattus norvegicus	71-75
29997797-2	2016	The novelty is in the selective creation of both H2 and O2 cocatalysts on surface active sites of g-C3N4via photodeposition triggering the splitting of water for the simultaneous evolution of H2 and O2 gases in a stoichiometric ratio of 2 : 1, irradiated with light, without using any sacrificial reagents.	Water	152-157	relaxin 2	Homo sapiens	49-58
29997797-2	2016	The novelty is in the selective creation of both H2 and O2 cocatalysts on surface active sites of g-C3N4via photodeposition triggering the splitting of water for the simultaneous evolution of H2 and O2 gases in a stoichiometric ratio of 2 : 1, irradiated with light, without using any sacrificial reagents.	Water	152-157	relaxin 2	Homo sapiens	192-201
9307875-5	1997	Examination of both the experiments that do not fulfill the expectations of the SCBT and the measurements of water liberation during the "contractile" process suggests a new outlook according to which tension development and movement are not due to major conformational changes but rather to restructuring of the hydration shells of actin and myosin.	Water	109-114	myosin heavy chain 14	Homo sapiens	343-349
27018215-1	2016	Aquaporin-4 (AQP4) is the Central Nervous System water channel highly expressed at the perivascular glial domain.	Water	49-54	aquaporin 4	Mus musculus	0-11
27018215-1	2016	Aquaporin-4 (AQP4) is the Central Nervous System water channel highly expressed at the perivascular glial domain.	Water	49-54	aquaporin 4	Mus musculus	13-17
27336788-10	2016	In addition, at times as short as 20-30 minutes, Stx2 and SubAB caused the inhibition of water absorption across HK-2 and HGEC monolayers and this effect was not related to a decrease in cell viability.	Water	89-94	syntaxin 2	Homo sapiens	49-53
9591194-6	1997	The majority of these studies have been conducted in a mouse skin tumor model system where tea is fed either as water extract through drinking water, or as purified GTP.	Water	112-117	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	91-94
27332135-5	2016	We show that such distinct response is largely caused by the overexpression of aquaporin-4 in tumor cells, with knockout of this water channel protein resulting in a markedly reduced change in the cellular volume.	Water	129-134	aquaporin 4	Homo sapiens	79-90
26928804-3	2016	Castration of Cyp1b1(+/+) mice or Cyp1b1(-/-) gene disruption minimized the angiotensin II-induced increase in water consumption, urine output, proteinuria, and sodium excretion and decreases in urine osmolality.	Water	111-116	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	14-20
26928804-3	2016	Castration of Cyp1b1(+/+) mice or Cyp1b1(-/-) gene disruption minimized the angiotensin II-induced increase in water consumption, urine output, proteinuria, and sodium excretion and decreases in urine osmolality.	Water	111-116	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	34-40
26259614-2	2016	Aquaporin 4 (AQP4) is the major water-channel membrane protein expressed in the central nervous system (CNS), primarily in astrocytes.	Water	32-37	aquaporin 4	Homo sapiens	0-11
9591194-6	1997	The majority of these studies have been conducted in a mouse skin tumor model system where tea is fed either as water extract through drinking water, or as purified GTP.	Water	143-148	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	91-94
26259614-2	2016	Aquaporin 4 (AQP4) is the major water-channel membrane protein expressed in the central nervous system (CNS), primarily in astrocytes.	Water	32-37	aquaporin 4	Homo sapiens	13-17
9116643-2	1996	Binding ability was related to human immunoglobulin G because bovine lactoferrin binding proteins were isolated by extraction of cell surface associated proteins with distilled water, applied on IgG-Sepharose and nickel sulphate chelate affinity chromatography.	Water	177-182	lactotransferrin	Bos taurus	69-80
26259614-3	2016	Emerging evidence suggests that AQP4 could play an important role in water and ion homeostasis in the brain, and it has been studied in various brain pathological conditions.	Water	69-74	aquaporin 4	Homo sapiens	32-36
27098934-6	2016	Tandem Oasis (MAX+MCX) was finally applied to extract the spiked analytes from tap water, surface water, and several wastewater samples.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
26407594-8	2016	Notably, basal urine osmolalities in both wild-type and UT-A1(+/+)/UT-A3(-/-) mice increased upon overnight water restriction.	Water	108-113	solute carrier family 14 (urea transporter), member 2	Mus musculus	56-61
26407594-8	2016	Notably, basal urine osmolalities in both wild-type and UT-A1(+/+)/UT-A3(-/-) mice increased upon overnight water restriction.	Water	108-113	solute carrier family 14 (urea transporter), member 2	Mus musculus	67-72
8971291-12	1996	Water immersion stress increased gastric mucosal IL-1 beta and IL-2 contents 6 h after stress treatment, and these increases were prevented by FK506.	Water	0-5	interleukin 2	Rattus norvegicus	63-67
27061315-0	2016	Rapid Detection of Melamine in Tap Water and Milk Using Conjugated "One-Step" Molecularly Imprinted Polymers-Surface Enhanced Raman Spectroscopic Sensor.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
27061315-4	2016	Principal component analysis segregated SERS spectral features of tap water and milk samples with different melamine concentrations.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
27061315-5	2016	Partial least squares regression models correlated melamine concentrations in tap water and skim milk with SERS spectral features.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
27061315-6	2016	The limit of detection (LOD) and limit of quantification (LOQ) of melamine in tap water were determined as 0.0019 and 0.0064 mmol/L, while the LOD and LOQ were 0.0165 and 0.055 mmol/L for the determination of melamine in skim milk.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
27061315-9	2016	The time required to determine melamine in tap water and milk were 6 and 25 min, respectively.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
27313504-4	2016	Aquaporin-4 is the main water channel in the CNS, is expressed in astrocyte foot processes in brain capillaries and along the circumventricular epithelium in the ventricles, and has important physiological functions in maintaining brain osmotic homeostasis and supporting brain excitability through regulation of the extracellular space.	Water	24-29	aquaporin 4	Homo sapiens	0-11
27313589-8	2016	Further analysis using a fluorescent dye revealed that ABA and water stress induced cell endocytosis or vesicle trafficking in a largely LIP5-dependent manner.	Water	63-68	hydroxyproline-rich glycoprotein family protein	Arabidopsis thaliana	137-141
28417085-4	2017	The EtOH-water extract significantly alleviated liver damage as indicated by the decreased levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the malondialdehyde (MDA) content, and increased the levels of superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GSH-Px), and reduced the pathological tissue injury induced by CCl4.	Water	9-14	chemokine (C-C motif) ligand 4	Mus musculus	376-380
8961147-7	1996	Freeze-induced denaturation of IL-1ra at the ice-water interface during freeze-drying was effectively prevented by adding a small amount of Tween 80.	Water	49-54	interleukin 1 receptor antagonist	Homo sapiens	31-37
9014472-8	1996	RT-PCR amplification with cDNAs constructed from peritoneal mRNA revealed the existence of both AQP1 (CHIP28) and AQP4 (MIWC) water channels in the peritoneum.	Water	126-131	aquaporin 4	Rattus norvegicus	114-118
28417085-8	2017	Based on the results, the EtOH-water extract from the seeds of F. rhynchophylla Hance is efficacious for prevention and treatment of CCl4-induced hepatic injury in mice.	Water	31-36	chemokine (C-C motif) ligand 4	Mus musculus	133-137
27144736-0	2016	Differential Water Thermodynamics Determine PI3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications.	Water	13-18	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	44-53
9014472-8	1996	RT-PCR amplification with cDNAs constructed from peritoneal mRNA revealed the existence of both AQP1 (CHIP28) and AQP4 (MIWC) water channels in the peritoneum.	Water	126-131	aquaporin 4	Rattus norvegicus	120-124
8944756-5	1996	We demonstrated, by means of introducing P25 tetramers into the membranes of Xenopus oocytes, that this protein exhibits functional properties similar to those of aquaporin 1, the archetypal water channel [Le Caherec, F., Bron, P., Verbavatz, J. M., Garret, A., Morel, G., Cavalier, A., Bonnec, G., Thomas, D., Gouranton, J.	Water	191-196	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	163-174
32263273-5	2016	The PPEGMA-b-P(DBAM-co-NFM) could be self-assembled easily into stable micelles with doxorubicin (DOX) with an average diameter of 66 nm in water.	Water	140-145	neurofilament medium chain	Homo sapiens	23-26
8901910-3	1996	However, in pure water or methanol SN1 reaction occurs mainly at C-2.	Water	17-22	complement C2	Homo sapiens	65-68
26255726-1	2016	Residents of Vietnam living in areas with water shortages collect and store tap water, when it is available, in containers, such as jars, which is then used for their daily activities.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	76-79
8798691-0	1996	Expression and functional analysis of water channels in a stably AQP2-transfected human collecting duct cell line.	Water	38-43	aquaporin 2	Homo sapiens	65-69
27242741-1	2016	The Ikka Fjord (SW Greenland) harbors a unique microbial habitat in the form of several hundred submarine tufa columns composed of ikaite, a special hexahydrate form of calcium carbonate that precipitates when alkaline phosphate- and carbonate-enriched spring water seeping out of the sea floor meets cold seawater.	Water	260-265	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	4-8
27140635-3	2016	The present work revealed that aquaporin 5 expression, a water channel critical for salivary gland fluid secretion, is regulated by bone morphogenetic protein 6.	Water	57-62	aquaporin 5	Mus musculus	31-42
8798691-17	1996	The redistribution of AQP2 in CD8 cells was accompanied by an approximately 6-fold increase in osmotic water permeability coefficient (Pf), which was inhibited by 0.3 m HgCl2.	Water	103-108	aquaporin 2	Homo sapiens	22-26
8885322-5	1996	The water wash from this column, containing AP1, was cleaned up on a 1 ml C-18 SPE column.	Water	4-9	anionic peroxidase	Zea mays	44-47
27152115-12	2016	CONCLUSION: Thermal water inhalation is able to modulate systemic immune response in elderly and young cURTI patients, thus reducing excessive production of Th1 and Th2-related cytokines, on the one hand.	Water	20-25	negative elongation factor complex member C/D	Homo sapiens	157-160
8931127-7	1996	SCR3 has a conformational stability in water of 12-13 kJ/mol whereas that of SCR1-3 is 19.5-19.9 kJ/mol depending upon the technique utilized.	Water	39-44	RNA binding motif single stranded interacting protein 2	Homo sapiens	0-4
26682649-2	2016	Inositol polyphosphate multikinase (IPMK) exhibits complex catalytic activities that eventually yield water-soluble inositol polyphosphates (e.g., IP4 and IP5) and lipid-bound phosphatidylinositol 3,4,5-trisphosphate.	Water	102-107	inositol polyphosphate multikinase	Homo sapiens	0-34
26682649-2	2016	Inositol polyphosphate multikinase (IPMK) exhibits complex catalytic activities that eventually yield water-soluble inositol polyphosphates (e.g., IP4 and IP5) and lipid-bound phosphatidylinositol 3,4,5-trisphosphate.	Water	102-107	inositol polyphosphate multikinase	Homo sapiens	36-40
8914624-6	1996	Lung water was elevated at 60 h of hyperoxia-exposure, and this effect was preceded by increases in lung MPO activities.	Water	5-10	myeloperoxidase	Rattus norvegicus	105-108
8703053-0	1996	Forskolin stimulation of water and cation permeability in aquaporin 1 water channels.	Water	25-30	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	58-69
8703053-0	1996	Forskolin stimulation of water and cation permeability in aquaporin 1 water channels.	Water	70-75	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	58-69
8703053-1	1996	Aquaporin 1, a six-transmembrane domain protein, is a water channel present in many fluid-secreting and -absorbing cells.	Water	54-59	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	0-11
27127798-7	2016	Orally administered CFTRact-J027 normalized stool output and water content in a loperamide-induced mouse model of constipation with ED50 ~0.5 mg/kg; CFTRact-J027 was without effect in cystic fibrosis mice lacking functional CFTR.	Water	61-66	cystic fibrosis transmembrane conductance regulator	Mus musculus	20-24
27407199-2	2016	The value of monolayer moisture content in the GAB model was calculated to be 0.081 kg water/kg dry solids by fitting water activity and moisture sorption data.	Water	87-92	alpha-1-B glycoprotein	Homo sapiens	47-50
26775247-7	2016	The control group was soaked in tap water.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
27101128-8	2016	The daily water intake of PMCA4 knockout mice was significantly lower compared to wild type littermates.	Water	10-15	ATPase, Ca++ transporting, plasma membrane 4	Mus musculus	26-31
27016434-4	2016	In-situ SbSPCE-CNF was successfully used for the simultaneous determination of Pb(II) and Cd(II) ions, by means of differential pulse anodic stripping voltammetry, in a certified reference estuarine water sample with a very high reproducibility and good trueness.	Water	199-204	NPHS1 adhesion molecule, nephrin	Homo sapiens	15-18
27010186-2	2016	In this approach, elaborately controlling the reaction temperature and volume ratio of i-PrOH and H2O enabled TaF5 to transform into intermediate coordination complex ions of [TaOF3 2F](2-) and [TaF7](2-), which subsequently produced tantalum oxyfluoride ACHNs via a secondary nucleation and growth due to a stepwise change in hydrolysis rates of the two complex ions.	Water	98-101	TATA-box binding protein associated factor 5	Homo sapiens	110-114
26998896-6	2016	Mobile GOx-microbots remove lead 10 times more efficiently than nonmotile GOx-microbots, cleaning water from 1000 ppb down to below 50 ppb in 60 min.	Water	98-103	hydroxyacid oxidase 1	Homo sapiens	7-10
26990105-4	2016	The results from single-reference and multireference methods are cross-checked, and the amount of multireference character for both considered spin states of [Fe(H2O)6](3+) is carefully analyzed.	Water	162-165	spindlin 1	Homo sapiens	143-147
26923221-2	2016	The dye doped CLC shells as a water-in-oil-in-water (W/O/W) double emulsion were fabricated by microfluidics.	Water	30-35	Charcot-Leyden crystal galectin	Homo sapiens	14-17
26923221-2	2016	The dye doped CLC shells as a water-in-oil-in-water (W/O/W) double emulsion were fabricated by microfluidics.	Water	46-51	Charcot-Leyden crystal galectin	Homo sapiens	14-17
26923221-3	2016	Water-dispersible Fe3O4 magnetic nanoparticles were incorporated in the inner aqueous phase by taking advantage of the immiscibility with the middle CLC oil phase.	Water	0-5	Charcot-Leyden crystal galectin	Homo sapiens	149-152
25995077-0	2016	Demonstration of glucose-6-phosphate hydrogen 5 enrichment from deuterated water by transaldolase-mediated exchange alone.	Water	75-80	transaldolase 1	Homo sapiens	84-97
26908838-1	2016	Acetazolamide (AZA) reduces the water permeability of aquaporin-4, the predominant water channel in the brain.	Water	32-37	aquaporin 4	Homo sapiens	54-65
26908838-1	2016	Acetazolamide (AZA) reduces the water permeability of aquaporin-4, the predominant water channel in the brain.	Water	83-88	aquaporin 4	Homo sapiens	54-65
27125665-8	2016	Daily patterns of food and water intake were abolished under ChrA In contrast, ChrD had no effect on body weight.	Water	27-32	chromogranin A	Mus musculus	61-65
26799805-0	2016	Human exposure to thallium through tap water: A study from Valdicastello Carducci and Pietrasanta (northern Tuscany, Italy).	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
26799805-4	2016	In September 2014 Tl contamination was also found in the tap water distributed in the same area (from 2 to 10mug/L).	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
26799805-9	2016	Thallium values found in biological samples were correlated with Tl concentrations found in tap water in the living area of each citizen, and with his/her habits.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
26838454-8	2016	The present study demonstrates the suitability of DNA bioinspired water-soluble polycations [(VBT)m(VBA)n](n+) 25 for enzyme immobilization like GOx into laponite hydrogels, and the preparation of highly sensitive and stable bioelectrodes on glassy carbon surface.	Water	66-71	hydroxyacid oxidase 1	Homo sapiens	145-148
26864530-10	2016	MCM significantly worsened ethanol-contaminated water isotope measurements by producing primary alcohol oxidation products such as formic acid, another compound that interferes with IRIS absorption.	Water	48-53	methylmalonyl-CoA mutase	Homo sapiens	0-3
26564554-3	2016	A number of randomized controlled trials have been completed to estimate the influence of tap water from municipal drinking water plants on the burden of AGI.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
26564554-4	2016	In Canada, 83% of the population (28 521 761 people) consumes tap water from municipal drinking water plants serving &gt;1000 people.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
26564554-10	2016	It is estimated that 334 966 cases (90% probability interval 183 006-501 026) of AGI per year are associated with the consumption of tap water from municipal systems that serve &gt;1000 people in Canada.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
27028365-2	2016	Here, we report the structure determined at 1.18 A resolution from twinned crystals of Arabidopsis thaliana aquaporin AtTIP2;1 and confirm water and ammonia permeability of the purified protein reconstituted in proteoliposomes as further substantiated by molecular dynamics simulations.	Water	139-144	delta tonoplast integral protein	Arabidopsis thaliana	118-126
8703053-2	1996	In Xenopus oocytes injected with aquaporin 1 complementary RNA, the application of forskolin or cyclic 8-bromo- adenosine 3",5"-monophosphate increased membrane permeability to water and triggered a cationic conductance.	Water	177-182	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	33-44
27028365-5	2016	By mutational studies, we show that the identified determinants in the extended selectivity filter region are sufficient to convert a strictly water-specific human aquaporin into an AtTIP2;1-like ammonia channel.	Water	143-148	delta tonoplast integral protein	Arabidopsis thaliana	182-190
8770861-1	1996	To evaluate the possible role of a putative vesicle-targeting protein, syntaxin-4, in vasopressin-regulated trafficking of aquaporin-2 water channel vesicles to the apical plasma membrane of renal collecting duct cells, we have carried out immunoblotting, immunocytochemistry, and reverse transcription (RT)-PCR experiments in rat kidney.	Water	135-140	syntaxin 4	Rattus norvegicus	71-81
27031475-3	2016	Aquaporin-4 (AQP4) is the major aquaporin in the mammalian brain, is mostly expressed on astrocytic endfeet, and functions as a water transporter.	Water	128-133	aquaporin 4	Homo sapiens	0-11
26851358-5	2016	The AF4-MALLS system enabled a complete analysis of mucilage carbohydrate aggregates in water, in which two populations were satisfactorily separated.	Water	88-93	AF4/FMR2 family member 1	Homo sapiens	4-7
8770861-1	1996	To evaluate the possible role of a putative vesicle-targeting protein, syntaxin-4, in vasopressin-regulated trafficking of aquaporin-2 water channel vesicles to the apical plasma membrane of renal collecting duct cells, we have carried out immunoblotting, immunocytochemistry, and reverse transcription (RT)-PCR experiments in rat kidney.	Water	135-140	aquaporin 2	Rattus norvegicus	123-134
8768930-14	1996	Moreover, uroguanylin and guanylin participate cooperatively in an intrinsic pathway for regulation of intestinal salt and water transport, thus providing another means of influencing salt and water homeostasis in addition to the renal actions of uroguanylin.	Water	123-128	guanylate cyclase activator 2A	Homo sapiens	13-21
26942307-6	2016	For three topologically similar fragments, the crystal structures reveal binding modes with different penetration, i.e., with zero, one, and two water molecules, respectively, located between the fragment and the side chain of a conserved tyrosine (Tyr1901) in the bottom of the acetyl lysine pocket of BAZ2B.	Water	145-150	bromodomain adjacent to zinc finger domain 2B	Homo sapiens	303-308
8768930-14	1996	Moreover, uroguanylin and guanylin participate cooperatively in an intrinsic pathway for regulation of intestinal salt and water transport, thus providing another means of influencing salt and water homeostasis in addition to the renal actions of uroguanylin.	Water	193-198	guanylate cyclase activator 2A	Homo sapiens	13-21
8770164-2	1996	It has been suggested that medullary ET-1 may affect water and sodium absorption along the collecting ducts in an autocrine fashion.	Water	53-58	endothelin 1	Mus musculus	37-41
26755729-2	2016	Xenopus laevis embryonic epidermal lectin (XEEL), an intelectin secreted into environmental water by the X. laevis embryo, is postulated to function as a defense against microbes.	Water	92-97	intelectin 1 L homeolog	Xenopus laevis	15-41
8799818-7	1996	Oocytes microinjected with either AQP1 or P25-proteoliposomes exhibited significantly increased osmotic membrane water permeabilities (Pf = 3.16 +/- 026 and 4.03 +/- 0.26 x 10(-3) cm/second, respectively) compared to those measured for oocytes injected with liposomes alone or with MIP26-proteoliposomes (Pf = 1.39 +/- 0.07 and 1.44 +/- 0.10 x 10(-3) cm/second, respectively).	Water	113-118	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	34-38
26774050-1	2016	Aquaporin-4 (AQP4), a water-selective membrane transport protein, is up-regulated in astrocytes in various inflammatory lesions, including Parkinson disease (PD).	Water	22-27	aquaporin 4	Mus musculus	0-11
26774050-1	2016	Aquaporin-4 (AQP4), a water-selective membrane transport protein, is up-regulated in astrocytes in various inflammatory lesions, including Parkinson disease (PD).	Water	22-27	aquaporin 4	Mus musculus	13-17
27069663-0	2016	A nuclear magnetic resonance study of water in aggrecan solutions.	Water	38-43	aggrecan	Homo sapiens	47-55
27069663-3	2016	The diffusion coefficients of the water molecules were also measured as a function of temperature and aggrecan concentration, using a pulsed field gradient technique at 9.4 T. Assuming an Arrhenius relationship, the activation energies for the various relaxation processes and the translational motion of the water molecules were determined from temperature dependencies as a function of aggrecan concentration in the range 0-5.3% w/w.	Water	34-39	aggrecan	Homo sapiens	102-110
8799818-9	1996	Arrhenius activation energies of water transfer were low when AQP1 or P25 were present in oocyte plasma membranes (Ea = 2.29 and 3.01 kcal/mol, respectively, versus Ea = 11.75 kcal/mol for liposome injected oocytes).	Water	33-38	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	62-66
8743482-2	1996	Together with the recent cloning of the vasopressin-regulated water channel in the apical membrane of the collecting duct tubule and of the identification of rare autosomal recessive nephrogenic diabetes insipidus patients with mutations in the AQP2 gene, these developments enable carrier detection and early diagnosis of infants with congenital nephrogenic diabetes insipidus.	Water	62-67	aquaporin 2	Homo sapiens	245-249
26905862-3	2016	We used arginine (A), glycine (G), and D-xylose (X) to generate the Maillard reaction by dissolving them in purified water and heating it to 150  C. This label-free process generated a complex compound (named AGX after its ingredients) with a monomer structure, which was determined by using nuclear magnetic resonance (NMR) and FTIR-FPA.	Water	117-122	UDP-N-acetylglucosamine pyrophosphorylase 1	Homo sapiens	209-212
26080391-0	2016	Use of a Cumulative Exposure Index to Estimate the Impact of Tap Water Lead Concentration on Blood Lead Levels in 1- to 5-Year-Old Children (Montreal, Canada).	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
8743483-5	1996	AQP2 is the predominant water channel in the apical plasma membrane and AQP3 and -4 are found in the basolateral plasma membrane.	Water	24-29	aquaporin 2	Homo sapiens	0-4
8743483-6	1996	Short-term regulation of collecting duct water permeability by vasopressin is largely a consequence of regulated trafficking of AQP2-containing vesicles to and from the apical plasma membrane.	Water	41-46	aquaporin 2	Homo sapiens	128-132
8743484-0	1996	The aquaporin family of water channels in kidney: an update on physiology and pathophysiology of aquaporin-2.	Water	24-29	aquaporin 2	Homo sapiens	97-108
8658528-4	1996	Two hours later there was dose-related production of IL-1alpha along with ear swelling and accumulation of skin water, all of which were partially prevented by intraperitoneal injection of antibody against murine IL-1alpha.	Water	112-117	interleukin 1 alpha	Mus musculus	213-222
30695500-1	2016	The aim of the present study was to compare effects of glucagon-like peptide-1 (GLP-1) mimetic exenatide on glucose and water-salt homeostasis in animals with different level of renal tubular proximal reabsorption - rats (Rattus norvegicus) and frogs (Rana temporaria).	Water	120-125	glucagon	Rattus norvegicus	80-85
30695500-4	2016	It is suggested that the invol- vement of GLP- 1 in regulation of water-salt homeostasis in mammals should be preceded by key evoluti- onary transformation - increase in glomerular filtration rate and proximal tubular reabsorption.	Water	66-71	glucagon	Rattus norvegicus	42-48
26689352-6	2016	Finally, tested in a panel of cancer cells, the water-soluble form of 3a, compound 8, displayed antiproliferative effects in the range of 8-35 muM and increased H4K16 deacetylation, suggesting a possible role for SIRT1 activators in cancer therapy.	Water	48-53	sirtuin 1	Homo sapiens	213-218
8639590-2	1996	In H2O, approximately 65% of the label is retained in the product (3); of this, one-third is at C-4 and two-thirds at C-6 beta.	Water	3-6	complement C4A (Rodgers blood group)	Homo sapiens	96-99
26781751-4	2016	The NPA, NBO and QTAIM approaches are used to probe covalency in the An-Oyl bond of AnO2(H2O)(+), and all metrics agree that these bonds become increasingly covalent as the 5f series is crossed, providing rationalisation for the increasingly endothermic isomerisation reactions.	Water	89-92	anoctamin 2	Homo sapiens	84-88
8621781-2	1996	We have recently shown that another cause of severe polyuria, chronic lithium therapy, is associated with decreased aquaporin-2 (AQP2) water channel expression (Marples, D., S. Christensen, E.I.	Water	135-140	aquaporin 2	Rattus norvegicus	116-127
26754135-2	2016	METHODS: Here we demonstrate that off-axis integrated cavity output (OA-ICOS) laser spectrometry, along with (2) H-enriched laboratory calibration standards and appropriate analysis templates, allows for low-cost, fast, and accurate determinations of water samples having delta(2) HVSMOW-SLAP values up to at least 57,000 % (~9000 ppm) at a processing rate of 60 samples per day.	Water	251-256	inducible T cell costimulator	Homo sapiens	72-76
26757444-0	2016	A Mononuclear Co(II) Coordination Complex Locked in a Confined Space and Acting as an Electrochemical Water-Oxidation Catalyst: A "Ship-in-a-Bottle" Approach.	Water	102-107	inositol polyphosphate-5-phosphatase D	Homo sapiens	131-135
8621781-2	1996	We have recently shown that another cause of severe polyuria, chronic lithium therapy, is associated with decreased aquaporin-2 (AQP2) water channel expression (Marples, D., S. Christensen, E.I.	Water	135-140	aquaporin 2	Rattus norvegicus	129-133
8621414-1	1996	Antidiuretic hormone modulates the water permeability (Pf) of epithelial cells in the rat kidney by vesicle-mediated insertion and removal of the aquaporin-2 (AQP-2) water channel.	Water	35-40	aquaporin 2	Rattus norvegicus	146-157
8621414-1	1996	Antidiuretic hormone modulates the water permeability (Pf) of epithelial cells in the rat kidney by vesicle-mediated insertion and removal of the aquaporin-2 (AQP-2) water channel.	Water	35-40	aquaporin 2	Rattus norvegicus	159-164
8621414-1	1996	Antidiuretic hormone modulates the water permeability (Pf) of epithelial cells in the rat kidney by vesicle-mediated insertion and removal of the aquaporin-2 (AQP-2) water channel.	Water	166-171	aquaporin 2	Rattus norvegicus	146-157
8621414-1	1996	Antidiuretic hormone modulates the water permeability (Pf) of epithelial cells in the rat kidney by vesicle-mediated insertion and removal of the aquaporin-2 (AQP-2) water channel.	Water	166-171	aquaporin 2	Rattus norvegicus	159-164
8601457-0	1996	A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach.	Water	2-7	aquaporin 4	Rattus norvegicus	45-56
26875987-0	2016	Cholesterol Promotes Interaction of the Protein CLIC1 with Phospholipid Monolayers at the Air-Water Interface.	Water	94-99	chloride intracellular channel 1	Homo sapiens	48-53
26739550-0	2016	Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases.	Water	0-5	xanthine dehydrogenase	Mus musculus	31-47
8615384-8	1996	Absorption of glucose, fructose, and lactulose was significantly inhibited by 0.1 mg x mL-1 protamine, while water absorption was decreased 41 percent by 1.0 mg x mL-1 protamine.	Water	109-114	L1 cell adhesion molecule	Mus musculus	163-167
26850728-10	2016	In vivo, compared to rats in IR and negative control group, intrathecal infusion of miR-320a mimic attenuated IR-induced lower limb motor function deficits and BSCB dysfunction as decreased EB extravasation and spinal water content through down-regulating AQP1 expressions, whereas pretreated with miR-320a AMO reversed above effects.	Water	218-223	microRNA 320a	Rattus norvegicus	84-92
26919281-2	2016	However, there are few experimental studies investigating S-allylmercaptocysteine (SAMC), a water-soluble derivative of garlic.	Water	92-97	solute carrier family 25 member 26	Homo sapiens	83-87
27061315-10	2016	The low LOD, LOQ, and rapid detection confirm the potential of applying this sensor for accurate and high-throughput detection of melamine in tap water and milk.	Water	146-151	nuclear RNA export factor 1	Homo sapiens	142-145
8785305-3	1996	Our experimental results permitted us to determine i) the diffusion constant of water in the samples, found to be between 1.4 x 10(-11) and 3.7 x 10(-11) m2/s; ii) a critical water content corresponding to the completion of the primary hydration layer, which is in the range 0.11-0.17 w/w, depending on the seed nature; and iii) the activation energy of the main relaxation mechanism, found to be equal to 0.54 +/- 0.05 eV.	Water	80-85	transcription elongation factor A1	Homo sapiens	157-162
26845170-7	2016	In the present work, male rats rendered motivated to obtain water, sex, or amphetamine showed an increase in Fos-ir of histaminergic neurons in appetitive behaviors directed to get those reinforcers.	Water	60-65	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-112
8785305-3	1996	Our experimental results permitted us to determine i) the diffusion constant of water in the samples, found to be between 1.4 x 10(-11) and 3.7 x 10(-11) m2/s; ii) a critical water content corresponding to the completion of the primary hydration layer, which is in the range 0.11-0.17 w/w, depending on the seed nature; and iii) the activation energy of the main relaxation mechanism, found to be equal to 0.54 +/- 0.05 eV.	Water	175-180	transcription elongation factor A1	Homo sapiens	157-162
26505315-1	2016	Diquafosol is known as a purinergic P2Y2 receptor (P2Y2R) agonist that stimulates water and mucin secretion from conjunctival epithelial cells and goblet cells, leading to tear film stability in dry eye.	Water	82-87	purinergic receptor P2Y2	Homo sapiens	51-56
8907703-0	1996	Vimentin in a cold-water fish, the rainbow trout: highly conserved primary structure but unique assembly properties.	Water	19-24	vimentin	Homo sapiens	0-8
26870010-1	2016	Biological stability of drinking water refers to the concept of providing consumers with drinking water of same microbial quality at the tap as produced at the water treatment facility.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	137-140
26833428-0	2016	Impairment of gastric accommodation induced by water-avoidance stress is mediated by 5-HT2B receptors.	Water	47-52	5-hydroxytryptamine receptor 2B	Cavia porcellus	85-91
8775227-3	1996	We have studied the effects of fever and convulsions on water and electrolyte balance in CSF and serum by measuring osmolality and electrolyte concentrations in children.	Water	56-61	colony stimulating factor 2	Homo sapiens	89-92
27107718-0	2016	Aquaporin 11, a regulator of water efflux at retinal Muller glial cell surface decreases concomitant with immune-mediated gliosis.	Water	29-34	aquaporin 11	Equus caballus	0-12
27107718-10	2016	We conclude a concomitant role for AQP11 with AQP4 in water efflux from these glial cells, which is disturbed in ERU.	Water	54-59	aquaporin 11	Equus caballus	35-40
27107718-12	2016	CONCLUSIONS: Therefore, AQP11 is important for physiological Muller glia function and the expression pattern and function of this water channel seems to have distinct functions in central nervous system.	Water	130-135	aquaporin 11	Equus caballus	24-29
26572434-13	2016	CNF composites had water absorption close to the neat resin at 1 wt% filler.	Water	19-24	NPHS1 adhesion molecule, nephrin	Homo sapiens	0-3
8852753-1	1996	A surfactant-induced conformational transition of bovine insulin has been detected by difference spectroscopy for a homologous series of n-alkytrimethylammonium bromides, chain length C10-C16 at pH 10.0, 25 degrees C. The transition was followed as a function of surfactant concentration by absorbance measurements at 275 nm and the data were analysed to obtain the Gibbs energy of the transition in water (delta Gw degree) and in a hydrophobic environment (delta Ghc degree) for saturated protein-surfactant complexes.	Water	400-405	insulin	Bos taurus	57-64
30090367-6	2016	The aim of this study was to evaluate Oat5 renal expression and urinary excretion in rats 48 h after the exposure to different doses of MTX, in comparison with traditional markers of renal injury, such as creatinine and urea plasma levels, protein urinary levels, urinary alkaline phosphatase (AP) activity, fractional excretion of water (FEWater) and renal histology.	Water	332-337	solute carrier family 22, member 24	Rattus norvegicus	38-42
26196932-5	2016	The sensor RBP was preliminarily applied to the determination of Al(3+) in water samples from the lake of Henan University and tap water with satisfying results.	Water	131-136	nuclear RNA export factor 1	Homo sapiens	127-130
28773419-0	2016	Spin-Coated vs. Electrodeposited Mn Oxide Films as Water Oxidation Catalysts.	Water	51-56	spindlin 1	Homo sapiens	0-4
28773419-3	2016	Spin coating consists of few preparation steps and employs green chemicals (i.e., ethanol, acetic acid, polyethylene oxide and water).	Water	127-132	spindlin 1	Homo sapiens	0-4
26991042-1	2016	A neutral mononuclear Fe(III) complex [Fe(III) (H-5-Br-thsa-Me)(5-Br-thsa-Me)] H2 O (1; H2 -5-Br-thsa-Me=5-bromosalicylaldehyde methylthiosemicarbazone) was prepared that exhibited a three-step spin-crossover (SCO) with symmetry breaking and a 14 K hysteresis loop owing to strong cooperativity.	Water	79-83	spindlin 1	Homo sapiens	194-198
26616970-0	2016	POD promoted oxidative gelation of water-extractable arabinoxylan through ferulic acid dimers.	Water	35-40	prx7	Hordeum vulgare	0-3
8869740-6	1996	Water-soluble inhibitors include strained cyclic phosphonates for PI-PLC and vanadate for PC-PLC.	Water	0-5	heparan sulfate proteoglycan 2	Homo sapiens	69-72
8869740-6	1996	Water-soluble inhibitors include strained cyclic phosphonates for PI-PLC and vanadate for PC-PLC.	Water	0-5	heparan sulfate proteoglycan 2	Homo sapiens	93-96
26476206-5	2016	Ethylene-regulated phosphorylation of aquaporin PIP2;1 is positively correlated with the water flux rate and water loss in leaf.	Water	89-94	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	48-54
9031517-1	1996	The structure of the solvent surrounding myoglobin crystals has been analyzed using neutron diffraction data, and the results indicate that the water around the protein is not disordered, but rather lies in well-defined hydration shells.	Water	144-149	myoglobin	Homo sapiens	41-50
26476206-5	2016	Ethylene-regulated phosphorylation of aquaporin PIP2;1 is positively correlated with the water flux rate and water loss in leaf.	Water	109-114	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	48-54
27158679-4	2016	The patient admitted to taking the contacts out in the evening and cleaning them with tap water before reapplying them in the morning.	Water	90-95	nuclear RNA export factor 1	Homo sapiens	86-89
9092458-0	1996	Understanding water: molecular dynamics simulations of myoglobin.	Water	14-19	myoglobin	Homo sapiens	55-64
26743650-2	2016	The results showed that root exudate components promoted the desorption of BDE-28 (57.6-235.0 %) and BDE-47 (56.9-223.7 %) from the soils due to the enhancement of their water solubilities.	Water	170-175	homeobox D13	Homo sapiens	75-78
26743650-2	2016	The results showed that root exudate components promoted the desorption of BDE-28 (57.6-235.0 %) and BDE-47 (56.9-223.7 %) from the soils due to the enhancement of their water solubilities.	Water	170-175	homeobox D13	Homo sapiens	101-104
27689074-0	2016	Molecular Characterization of LRB7 Gene and a Water Channel Protein TIP2 in Chorispora bungeana.	Water	46-51	tonoplast intrinsic protein 2	Arabidopsis thaliana	68-72
26133080-6	2016	Microemulsion viscosity was reduced by increasing oil and water percentages (p &lt; 0.05), due to the inherent high viscosity of the utilized SAA/CoS.	Water	58-63	serum amyloid A1 cluster	Homo sapiens	142-145
9092458-1	1996	Molecular dynamics simulations were performed on CO myoglobin to evaluate the stability of the bound water molecules as determined in a neutron diffraction analysis.	Water	101-106	myoglobin	Homo sapiens	52-61
26803211-4	2016	Soil and house dust were sieved, digested, and analyzed via ICP-MS. Tap water and urine were analyzed without digestion, while toenails were washed, digested and analyzed.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
26803211-12	2016	Mixed models showed that soil and tap water best predicted urinary arsenic.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
9092458-4	1996	Comparison between myoglobin in solution and in a single crystal highlighted some of the packing effects on the solvent structure and shows that water solvent plays an indispensable role in protein dynamics and structural stability.	Water	145-150	myoglobin	Homo sapiens	19-28
9161697-3	1996	This study reports that an intratesticular injection of low doses of a uveitogenic eicosapeptide (P343-362) of S-antigen prior to immunization with the same peptide prevented the onset of EAU by inducing systemic tolerance, designated orchidic tolerance.	Water	188-191	S-antigen visual arrestin	Rattus norvegicus	111-120
26593484-4	2016	Results showed that dietary MRP reduced the food efficiency, increased the antioxidant activity of serum, increased the ratio between lactic and total aerobic bacteria, increased water-holding capacity of faeces and reduced blood pressure, but did not reduce mineral absorption.	Water	179-184	ATP binding cassette subfamily C member 2	Rattus norvegicus	28-31
26921309-10	2016	Mincle activation was sufficient to generate the EAU phenotype, and this required activation of both Syk and Card9.	Water	49-52	spleen associated tyrosine kinase	Homo sapiens	101-104
8569695-6	1996	Expressed human microsomal epoxide hydrolase and HLM catalyzed the attack of water predominantly (approximately 96%) at C5 of the 5R,6S-oxide, whereas 5S,6R-oxide was attacked less selectivity (approximately 60% at C5).	Water	77-82	epoxide hydrolase 1	Homo sapiens	16-44
26921309-10	2016	Mincle activation was sufficient to generate the EAU phenotype, and this required activation of both Syk and Card9.	Water	49-52	caspase recruitment domain family member 9	Homo sapiens	109-114
8594889-1	1995	We determined whether aquaporin of collecting duct (AQP-CD) is involved in pathogenesis of water retention in rats with experimental models of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and liver cirrhosis.	Water	91-96	aquaporin 2	Rattus norvegicus	52-58
26791475-1	2016	The present study aimed to investigate the potential physiological role of vasopressin and the incretin hormone of the gastrointestinal tract (glucagon-like peptide-1; GLP-1) in the regulation of the water-salt balance in a hyperosmolar state as a result of sodium loadings.	Water	200-205	glucagon	Rattus norvegicus	143-166
26791475-1	2016	The present study aimed to investigate the potential physiological role of vasopressin and the incretin hormone of the gastrointestinal tract (glucagon-like peptide-1; GLP-1) in the regulation of the water-salt balance in a hyperosmolar state as a result of sodium loadings.	Water	200-205	glucagon	Rattus norvegicus	168-173
8594889-9	1995	These results indicate that water channel AQP-CD plays an important role in water retention in pathological states of SIADH and liver cirrhosis.	Water	28-33	aquaporin 2	Rattus norvegicus	42-48
8594889-9	1995	These results indicate that water channel AQP-CD plays an important role in water retention in pathological states of SIADH and liver cirrhosis.	Water	76-81	aquaporin 2	Rattus norvegicus	42-48
8821599-1	1995	BRL 49594A (BRL) is a water soluble analogue of amphotericin B which has been developed as a polyene with efficacy similar to amphotericin B but with much reduced toxicity.	Water	22-27	von Willebrand factor C domain-containing protein 2-like	Mus musculus	0-3
27105415-6	2016	We can infer that nationwide more than 1,000 clusters involving 30,000 cases of cAGE each year may be linked to tap water.	Water	116-121	nuclear RNA export factor 1	Homo sapiens	112-115
8821599-1	1995	BRL 49594A (BRL) is a water soluble analogue of amphotericin B which has been developed as a polyene with efficacy similar to amphotericin B but with much reduced toxicity.	Water	22-27	von Willebrand factor C domain-containing protein 2-like	Mus musculus	12-15
26638718-3	2016	The aim of the present study was to investigate possible protective effects of S. bachtiarica methanolic extract on Abeta induced spatial memory impairment in Morris Water Maze (MWM), oxidative stress and cholinergic neuron degeneration.	Water	166-171	amyloid beta precursor protein	Rattus norvegicus	116-121
8539261-13	1995	Administration of corticosterone (B; 25 micrograms/ml of 0.9% saline drinking water) to AxDb rats restored Db-like profiles of all IGFBPs.	Water	78-83	insulin-like growth factor binding protein 1	Rattus norvegicus	131-137
26858365-5	2016	Moreover, stimulation of NDA2-dependent chlororespiration affords additional relief from the elevated reduction state associated with N deprivation through plastid terminal oxidase-dependent water synthesis.	Water	191-196	uncharacterized protein	Chlamydomonas reinhardtii	25-29
8633765-2	1995	Cyclic voltammetry, controlled-potential electrolysis, HPLC/UV analysis, LC/MS/MS analysis, and EPR spin-trapping studies indicate that the electrolysis-induced oxidative degradation of GHRP is likely to be mediated by electrogenerated oxygen radicals from the electrolysis of water.	Water	277-282	ghrelin and obestatin prepropeptide	Homo sapiens	186-190
26959718-3	2016	The pTB nanotube has a length of ~40 A that spans the membrane and a uniform inner diameter of 4 A that holds a single-file water-chain.	Water	124-129	polypyrimidine tract binding protein 1	Homo sapiens	4-7
9223015-7	1995	Induced lipid interaction via N-terminal lipo-derivatization of gastrin and CCK allowed to translocate quantitatively the two hormones into phospholipid bilayers and to examine the effect of extravesicular Ca2+ on the conformation of the peptide headgroups and on their display at the water/lipid interphase.	Water	285-290	gastrin	Homo sapiens	64-71
27047801-5	2016	Thus, 3O-C12-HSL enhanced cell volume and area and induced cell shape and protrusion fluctuations in macrophages, processes tentatively driven by fluxes of water across cell membrane through AQP9, the predominant AQP in macrophages.	Water	156-161	lipase E, hormone sensitive type	Homo sapiens	13-16
9223015-9	1995	Conversely, insertion of lipo-gastrin into the bilayers leads to full exposure of the gastrin headgroup to the bulk water in predominantly random coil structure.	Water	116-121	gastrin	Homo sapiens	30-37
26990978-2	2016	Most patients harbor pathogenic autoantibodies, the so-called NMO-IgGs, which are directed against the water channel aquaporin 4 (AQP4) on astrocytes.	Water	103-108	aquaporin 4	Homo sapiens	130-134
9223015-9	1995	Conversely, insertion of lipo-gastrin into the bilayers leads to full exposure of the gastrin headgroup to the bulk water in predominantly random coil structure.	Water	116-121	gastrin	Homo sapiens	86-93
7492620-1	1995	Cytochrome P-450c21 (CYP21A1) purified from bovine adrenocortical microsomes was investigated by electron paramagnetic resonance (EPR) spectroscopy to clarify the interactions among heme active center, protein surroundings, water molecules and bound substrates or analogues.	Water	224-229	steroid 21-hydroxylase	Bos taurus	0-19
26547431-8	2016	The functionality of quinolone-specific aptamers in real water samples was demonstrated in local tap water and in effluents of sewage plants.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	97-100
26547431-8	2016	The functionality of quinolone-specific aptamers in real water samples was demonstrated in local tap water and in effluents of sewage plants.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
7492573-0	1995	Retinal Schiff base chromophore in the surfactant solubilised water pools in CCl4.	Water	62-67	C-C motif chemokine ligand 4	Homo sapiens	77-81
26696414-5	2016	The glycoconjugate constructs become stable to silica gel chromatography and to water solutions at physiological pH, while preserving water solubility and activity in an SPR assay against the murine MBL-C isoform.	Water	134-139	mannose-binding lectin (protein C) 2	Mus musculus	199-204
8549684-4	1995	MM also completely inhibited in most treated rats the development of EAU adoptively transferred by SAg-sensitized lymphocytes, thus depicting its capacity to inhibit the efferent limb of the immune response.	Water	69-72	S-antigen visual arrestin	Rattus norvegicus	99-102
29899925-1	2016	A library of water-soluble dynamic single-chain polymeric nanoparticles (SCPN) was prepared using a controlled radical polymerisation technique followed by the introduction of functional groups, including probes at targeted positions.	Water	13-18	carboxypeptidase N subunit 1	Homo sapiens	73-77
7496995-5	1995	Water deprivation of rabbits resulted in an increase of phospholipase A2 activity from 2.7 +/- 0.4 (n = 5) and 5.7 +/- 0.7 (n = 5) to 5.0 +/- 0.8 (n = 5) and 10.8 +/- 1.3 (n = 5) pmol of fatty acid released/min per mg protein in mitochondrial and microsomal fractions, respectively, using dipalmitoyl phosphatidilcholine as substrate while the activity of cytosolic enzyme remained unchanged.	Water	0-5	phospholipase A2	Oryctolagus cuniculus	56-72
26869048-0	2016	Perchlorate levels found in tap water collected from several cities in Turkey.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
26869048-4	2016	The aim of this study was to determine the perchlorate levels in tap water from five cities in Turkey.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
8593294-0	1995	Effect of vasoactive intestinal polypeptide (VIP) on the net movement of electrolytes and water and glucose absorption in the jejunal loop of sheep.	Water	90-95	vasoactive intestinal peptide	Ovis aries	10-43
26938163-1	2016	PURPOSE: The use of tap water as a wound-cleansing agent is becoming more common in clinical practice, especially in community settings.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
8593294-0	1995	Effect of vasoactive intestinal polypeptide (VIP) on the net movement of electrolytes and water and glucose absorption in the jejunal loop of sheep.	Water	90-95	vasoactive intestinal peptide	Ovis aries	45-48
26938163-11	2016	CONCLUSIONS: Study findings indicate that tap water is a safe alternative to sterile normal saline for wound cleansing in a community setting.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
8593294-6	1995	VIP decreased water absorption at 10 and 30 pmol/kg/hr and converted to secretion at over 100 pmol/kg/hr in a dose-dependent manner.	Water	14-19	vasoactive intestinal peptide	Ovis aries	0-3
8593294-11	1995	Our findings indicate that VIP stimulates the jejunal secretion of water, sodium, potassium and bicarbonate and that VIP does not inhibit glucose absorption when the secretion of luminal fluid is accelerated by VIP in the jejunal loop of sheep.	Water	67-72	vasoactive intestinal peptide	Ovis aries	27-30
15299808-2	1995	Resulting graphs of the concentrations of PEG and salt that are equivalent with respect to the vapor pressure of water are non-linear, do not intersect their origins, and demonstrate that relatively low (mM) salt concentrations are equivalent to relatively high PEG concentrations.	Water	113-118	progestagen associated endometrial protein	Homo sapiens	42-45
26735936-9	2016	Through this approach, we demonstrate that the C-terminal domain of SELK (i) presents a poor content of regular secondary structure elements, (ii) is dynamically stabilized by a network of intra-molecular H-bonds and H-bonds with water molecules, (iii) is highly fluctuating and, therefore, can be described only through a conformational ensemble, where we evidenced a distribution of equilibrium conformers which continuously inter-change their conformations.	Water	230-235	selenoprotein K	Homo sapiens	68-72
33579146-0	2016	High occurrence of potentially-pathogenic free-living amoebae in tap water and recreational water sources in South-West Iran.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
26571428-0	2016	Drugs of abuse, cytostatic drugs and iodinated contrast media in tap water from the Madrid region (central Spain):A case study to analyse their occurrence and human health risk characterization.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
26571428-1	2016	This work analyses the presence of forty-eight emerging pollutants, including twenty-five drugs of abuse and metabolites, seventeen cytostatic drugs and six iodinated contrast media, in tap water from the Madrid Region.	Water	190-195	nuclear RNA export factor 1	Homo sapiens	186-189
26571428-2	2016	Analysis of the target compounds in the tap water was performed by means of (on-line or off-line) solid-phase extraction followed by analysis by liquid chromatography-tandem mass spectrometry.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
33579146-4	2016	Thirty percent of tap water samples in Ahvaz city were also positive for potentially pathogenic Free Living Amoebae.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
15299808-2	1995	Resulting graphs of the concentrations of PEG and salt that are equivalent with respect to the vapor pressure of water are non-linear, do not intersect their origins, and demonstrate that relatively low (mM) salt concentrations are equivalent to relatively high PEG concentrations.	Water	113-118	progestagen associated endometrial protein	Homo sapiens	262-265
7573546-0	1995	ACE inhibition prevents Na and water retention and MABP increase during reduction of renal perfusion pressure.	Water	31-36	angiotensin I converting enzyme	Canis lupus familiaris	0-3
26833293-1	2016	A novel water-soluble mitochondria-targeted ratiometric fluorescent probe (Cl-2) is presented.	Water	8-13	endogenous retrovirus group W member 5	Homo sapiens	75-79
26917751-0	2016	How do you like your tap water?	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
28050195-5	2016	Our results show that promoter activity and mRNA and protein expression levels of the SR-BI were significantly upregulated by Tiaozhi granules alcohol or water extracts in a dose-dependent manner.	Water	154-159	scavenger receptor class B member 1	Homo sapiens	86-91
28050195-7	2016	Both Tiaozhi granule alcohol and water extracts can upregulate SR-BI gene expression.	Water	33-38	scavenger receptor class B member 1	Homo sapiens	63-68
7573546-8	1995	In conclusion, angiotensin-converting enzyme inhibition can prevent the otherwise obligatory Na and water retention and systemic MABP increase during a 20% reduction in renal perfusion pressure.	Water	100-105	angiotensin I converting enzyme	Canis lupus familiaris	15-44
7671346-4	1995	Metabolism of BaP to water-soluble metabolites by HepG2 cells in culture was 50% lower in fluorescein isothiocyanate (FITC)-insulin-CYP1A1-antibody-conjugate-treated cells than in control cells.	Water	21-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138
27112688-1	2016	Neuromyelitis optica (NMO) spectrum disorders (SD) represent an evolving group of central nervous system (CNS)-inflammatory autoimmune demyelinating diseases unified by a pathogenic autoantibody specific for the aquaporin-4 (AQP4) water channel.	Water	231-236	aquaporin 4	Homo sapiens	212-223
27112688-1	2016	Neuromyelitis optica (NMO) spectrum disorders (SD) represent an evolving group of central nervous system (CNS)-inflammatory autoimmune demyelinating diseases unified by a pathogenic autoantibody specific for the aquaporin-4 (AQP4) water channel.	Water	231-236	aquaporin 4	Homo sapiens	225-229
26444796-0	2016	Dietary high cholesterol and trace metals in the drinking water increase levels of ABCA1 in the rabbit hippocampus and temporal cortex.	Water	58-63	ATP-binding cassette sub-family A member 1	Oryctolagus cuniculus	83-88
26444796-5	2016	The number of neurons with ABCA1 immunoreactivity was further increased in all three areas as a result of cholesterol-fed rabbits drinking tap water or distilled water with copper.	Water	143-148	ATP-binding cassette sub-family A member 1	Oryctolagus cuniculus	27-32
26941623-1	2016	Aquaporin-4 (AQP4) is the predominant water channel expressed by astrocytes in the central nervous system (CNS).	Water	38-43	aquaporin 4	Mus musculus	0-11
26941623-1	2016	Aquaporin-4 (AQP4) is the predominant water channel expressed by astrocytes in the central nervous system (CNS).	Water	38-43	aquaporin 4	Mus musculus	13-17
26941623-3	2016	The bidirectional water transport function of AQP4 suggests its role in cerebral water balance in the CNS.	Water	18-23	aquaporin 4	Mus musculus	46-50
26781751-1	2016	The enthalpies of the reactions AnO2(+)  AnO(+) + O and AnO2(+) + H2O   AnO2(H2O)(+), and those of the isomerisation of the latter to AnO(OH)2(+), have been calculated for An = Pa-Pu.	Water	66-69	anoctamin 2	Homo sapiens	56-60
26781751-1	2016	The enthalpies of the reactions AnO2(+)  AnO(+) + O and AnO2(+) + H2O   AnO2(H2O)(+), and those of the isomerisation of the latter to AnO(OH)2(+), have been calculated for An = Pa-Pu.	Water	66-69	anoctamin 2	Homo sapiens	56-60
26781751-1	2016	The enthalpies of the reactions AnO2(+)  AnO(+) + O and AnO2(+) + H2O   AnO2(H2O)(+), and those of the isomerisation of the latter to AnO(OH)2(+), have been calculated for An = Pa-Pu.	Water	77-80	anoctamin 2	Homo sapiens	56-60
26781751-1	2016	The enthalpies of the reactions AnO2(+)  AnO(+) + O and AnO2(+) + H2O   AnO2(H2O)(+), and those of the isomerisation of the latter to AnO(OH)2(+), have been calculated for An = Pa-Pu.	Water	77-80	anoctamin 2	Homo sapiens	56-60
26444796-5	2016	The number of neurons with ABCA1 immunoreactivity was further increased in all three areas as a result of cholesterol-fed rabbits drinking tap water or distilled water with copper.	Water	162-167	ATP-binding cassette sub-family A member 1	Oryctolagus cuniculus	27-32
26444796-6	2016	Finally, cholesterol-fed rabbits that drank distilled water with aluminum also showed an increased number of ABCA1-immunopositive neurons in inferior and superior temporal cortex.	Water	54-59	ATP-binding cassette sub-family A member 1	Oryctolagus cuniculus	109-114
26444796-7	2016	CONCLUSIONS: These data suggest that ABCA1 levels increase in parallel with previously documented increases in Abeta levels as a result of high dietary cholesterol and copper in the drinking water.	Water	191-196	ATP-binding cassette sub-family A member 1	Oryctolagus cuniculus	37-42
7628605-2	1995	In D2O both HD and D2 are formed from CH2 = H4MPT and in H2O both HD and H2 from CD2 = H4MPT.	Water	57-60	CD2 molecule	Homo sapiens	81-84
26454333-7	2016	LIMITATIONS: The limitations of the present study include the lack of data relevant to lithium levels in food and the proportion of the population who drank tap water and their consumption habits.	Water	161-166	nuclear RNA export factor 1	Homo sapiens	157-160
26803001-7	2016	The elaborated microsensor showed fast responses towards catechol additions to tap water - a weakly supported medium - characterized by a linear range from 0.2 to 10 muM, a sensitivity of 1.35 +- 0.4 A M(-1) cm(-2) and a dynamic range up to 43 muM.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
7575330-1	1995	The advances in our understanding of the pathophysiology of defects in the antidiuretic hormone, the V2 receptor and the water channel, owing to mutations in the prepro-AVP-NPII, AVPR2 and AQP2 genes respectively, is providing insight into inherited diabetes insipidus as well as the more numerous sporadic cases.	Water	121-126	aquaporin 2	Homo sapiens	189-193
26787982-3	2016	It was found that blanching in distilled water had no effect on discolouration when blanching conditions were at 75, 85, and 95  C for 7 min but the violet-red discolouration occurred only when tap water was used for blanching at 95  C for 7 min.	Water	198-203	nuclear RNA export factor 1	Homo sapiens	194-197
26787982-4	2016	Moreover, the addition of bicarbonate (NaHCO3) in distilled water to imitate higher alkalinity of tap water during blanching could contribute to the violet-red discolouration.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	98-101
26860258-10	2016	Poultry-associated campylobacteriosis was linked to poultry consumption in wintertime, and ruminant-associated campylobacteriosis to tap-water provider type.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
26787982-4	2016	Moreover, the addition of bicarbonate (NaHCO3) in distilled water to imitate higher alkalinity of tap water during blanching could contribute to the violet-red discolouration.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
7491270-1	1995	Permeabilities to glycerol and small non-electrolytes of three Aquaporin 1 CHIP (AQP1) water channels were measured in AQP1 cRNA-injected Xenopus laevis oocytes and in human AQP1 channels reconstituted in proteoliposomes.	Water	87-92	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	63-79
26787982-6	2016	After sterilization, there was no violet-red discolouration from Palmyra palm flesh without any peel left on even though it had a preceding treatment of blanching in highly alkaline tap water.	Water	186-191	nuclear RNA export factor 1	Homo sapiens	182-185
26839261-4	2016	It appears fundamentally impossible to accurately predict from statistical properties of the surfaces alone how strongly we have to tighten a water tap to make it stop dripping and also how it starts dripping once we loosen it again.	Water	142-147	nuclear RNA export factor 1	Homo sapiens	148-151
7491270-1	1995	Permeabilities to glycerol and small non-electrolytes of three Aquaporin 1 CHIP (AQP1) water channels were measured in AQP1 cRNA-injected Xenopus laevis oocytes and in human AQP1 channels reconstituted in proteoliposomes.	Water	87-92	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	81-85
26519201-6	2016	The obtained results showed that this analytical method would be useful for the analysis of fenitrothion, diazinon, and ethion in tap water with high precision and accuracy.	Water	134-139	nuclear RNA export factor 1	Homo sapiens	130-133
7491270-1	1995	Permeabilities to glycerol and small non-electrolytes of three Aquaporin 1 CHIP (AQP1) water channels were measured in AQP1 cRNA-injected Xenopus laevis oocytes and in human AQP1 channels reconstituted in proteoliposomes.	Water	87-92	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	119-123
27041283-4	2016	METHODS: EAU was induced in C57BL/6 mice by subcutaneous application of IRBP (interphotoreceptor retinoid binding protein) in complete Freunds adjuvant and intraperitoneal application of pertussis toxin.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	72-76
7491270-9	1995	All these results provide strong evidence that water and certain small solutes permeate the AQP1 channels expressed at the surface of X. laevis oocytes or reconstituted in proteoliposomes.	Water	47-52	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	92-96
27041283-4	2016	METHODS: EAU was induced in C57BL/6 mice by subcutaneous application of IRBP (interphotoreceptor retinoid binding protein) in complete Freunds adjuvant and intraperitoneal application of pertussis toxin.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	78-121
7794896-3	1995	Group I (acetone, THF, and pyridine-d5 solutions) gives a spectrum with a Qy band around 665 nm while group II (CS2 and water-saturated CCl4 solutions) shows a spectrum typical of BChl-c aggregates with a broader red-shifted Qy band.	Water	120-125	C-C motif chemokine ligand 4	Homo sapiens	136-140
27244873-4	2016	Since untreated depression is the most powerful risk factor for suicidal behaviour, we postulated that the consumption of arsenic-contaminated tap drinking-water may also be related to suicide.	Water	156-161	nuclear RNA export factor 1	Homo sapiens	143-146
27852967-10	2016	CONCLUSIONS: Results indicate that lithium intake from tap water in doses far below those used in the clinical practice may have suicide-preventive effects.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
27852967-11	2016	This raises the possibility that lithium supplementation of tap water may open a new avenue in suicide prevention.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
27852967-12	2016	In Hungary, where there is a stable in time spatial inhomogeneity of the suicide rate it would be especially interesting to test whether regional differences in lithium content of tap water contribute to this phenomenon.	Water	184-189	nuclear RNA export factor 1	Homo sapiens	180-183
7794896-8	1995	Of particular note is that bands due to C = O stretching modes of the ester group are observed at 1733, 1719, and 1705 cm-1 in the spectrum of BChl-c in water-saturated CCl4.	Water	153-158	C-C motif chemokine ligand 4	Homo sapiens	169-173
26400205-3	2016	Three weeks after vector delivery, EAU was induced with a subcutaneous injection of a mixture of interphotoreceptor retinoid binding protein (IRBP) peptide with CFA.	Water	35-38	retinol binding protein 3, interstitial	Mus musculus	97-140
26400205-3	2016	Three weeks after vector delivery, EAU was induced with a subcutaneous injection of a mixture of interphotoreceptor retinoid binding protein (IRBP) peptide with CFA.	Water	35-38	retinol binding protein 3, interstitial	Mus musculus	142-146
26839610-7	2015	These results suggest an association between the RPE-overall with all cardiorespiratory and two neuromuscular variables during the execution of a water-based aerobic exercise using water-floating equipment.	Water	146-151	ribulose-5-phosphate-3-epimerase	Homo sapiens	49-52
7541941-0	1995	Vasopressin increases AQP-CD water channel in apical membrane of collecting duct cells in Brattleboro rats.	Water	29-34	aquaporin 2	Rattus norvegicus	22-28
26666293-8	2015	The structure of the homo-trimeric A. thaliana dUTPase showed three active sites, each with a different set of ligand interactions between the amino acids and water molecules.	Water	159-164	Deoxyuridine triphosphatase	Drosophila melanogaster	47-54
26870010-9	2016	We discussed, how knowledge gained from novel techniques will improve design and monitoring of water treatment and distribution systems in order to maintain good drinking water microbial quality up to consumer"s tap.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	212-215
7541941-3	1995	In rats given vasopressin 15 min before death, the number of immunogold particles for AQP-CD in the apical membrane increased significantly (P &lt; 0.002) from 1.8 +/- 0.2 to 10.0 +/- 0.4/microns with a significant decrease (P &lt; 0.05) of cytoplasmic labeling from 32.6 +/- 6.4 to 24.6 +/- 5.6/microns 2, indicating that AQP-CD is the vasopressin-regulated water channel predicted by the "shuttle" hypothesis.	Water	359-364	aquaporin 2	Rattus norvegicus	86-92
9398947-2	1995	Supplementation of drinking water with vanadium at the level of 0.2 or 0.5 ppm for 4, 8, or 12 wk was found to increase the GSH level with a concomitant elevation in GST activity in the liver followed by small intestine mucosa, large intestine mucosa, and kidney.	Water	28-33	hematopoietic prostaglandin D synthase	Rattus norvegicus	166-169
26682810-1	2015	The water channel aquaporin-4 (AQP4) forms supramolecular clusters whose size is determined by the ratio of M1- and M23-AQP4 isoforms.	Water	4-9	aquaporin 4	Homo sapiens	18-29
26682810-1	2015	The water channel aquaporin-4 (AQP4) forms supramolecular clusters whose size is determined by the ratio of M1- and M23-AQP4 isoforms.	Water	4-9	aquaporin 4	Homo sapiens	31-35
26682810-1	2015	The water channel aquaporin-4 (AQP4) forms supramolecular clusters whose size is determined by the ratio of M1- and M23-AQP4 isoforms.	Water	4-9	aquaporin 4	Homo sapiens	120-124
7494090-5	1995	The radioactivity associated with ras p21 bound to the phosphocellulose paper was determined by scintillation counting after soaking the paper in trichloroacetic acid and washing with distilled water.	Water	194-199	H3 histone pseudogene 16	Homo sapiens	38-41
26363608-5	2015	Triethyl phosphate (TEP) was the most abundant OPE in the tap water and filtered drinking water with median concentrations of 50.2 and 30.2ng/L, respectively.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
7558005-1	1995	A cDNA encoding rat AQP3, a water channel and a member of the MIP family, that is expressed predominantly in kidney medulla and colon was cloned recently.	Water	28-33	aquaporin 3 (Gill blood group)	Rattus norvegicus	20-24
26653310-10	2015	The number of residents, presence of pets, and local tap water also influenced the diversity and size of indoor air microbes.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
26653310-12	2015	Vacuum cleaning increased the signature of pet- and floor-derived bacteria in indoor air, while the frequency of natural ventilation decreased the relative abundance of tap water-derived microorganisms in air.	Water	173-178	nuclear RNA export factor 1	Homo sapiens	169-172
7653875-2	1995	FVL with positive end expiration pressure +5 or +10 cm H2O was found to be the optimal for patients with compensated shock.	Water	55-58	coagulation factor V	Homo sapiens	0-3
26642044-1	2015	The effect of high hydrostatic pressure (HHP) on the susceptibility of potato starch (25%, w/v) suspended in water to degradation by exposure to bacterial alpha-amylase (0.02%, 0.04% and 0.06%, w/v) for 40 min at 25 C was investigated.	Water	109-114	alpha-amylase	Solanum tuberosum	155-168
26627307-4	2015	Here, we demonstrate that in the presence of Boc-7-aminoheptanoic acid (Boc-7), phase separation occurs in mixtures of miscible organic solvent and water.	Water	148-153	BOC cell adhesion associated, oncogene regulated	Homo sapiens	45-48
7612819-2	1995	Electron cryo-microscopy was used to determine the three-dimensional structure of bovine rhodopsin from tilted two-dimensional crystals embedded in vitrified water.	Water	158-163	rhodopsin	Bos taurus	89-98
26191779-15	2015	There was interaction between calcium and copper on hip fracture risk in men (p=0.051); the association between calcium and hip fracture risk was stronger when the copper concentration in water was high (IRR=0.52, 95% CI: 0.35, 0.78) as opposed to when it was low (IRR=0.88, 95% CI: 0.81, 0.94).	Water	188-193	insulin receptor related receptor	Homo sapiens	204-207
7552246-0	1995	Water deprivation induces regional expression of c-fos protein in the brain of inbred polydipsic mice.	Water	0-5	FBJ osteosarcoma oncogene	Mus musculus	49-62
26553436-10	2015	However, their concentration was very low and the maximum values for IBP, NPX, DIC, and IDM were 47, 39, 24, and 37 ng/L, respectively, in tap water samples.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
7625574-6	1995	Lymphokine-activated killer (LAK) cells from both ethanol-consuming and water-drinking mice were &gt; 95% NK1.1+.	Water	72-77	killer cell lectin-like receptor subfamily B member 1C	Mus musculus	106-111
26677259-8	2015	Collectively, these results suggest that AQP1a1 in zebrafish larvae facilitates the movement of CO2 and ammonia, as well as water, in a physiologically relevant fashion.	Water	124-129	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	41-47
26254065-6	2015	CAPSULE: This study shows that the microbial community composition and thus OMP removal is primarily determined by the aqueous phase (water quality) rather than the soil phase.	Water	134-139	olfactory marker protein	Homo sapiens	76-79
27097462-1	2015	The odorous compounds of 2-methylisoborneol (2-MIB) and geosmin (GSM) heavily produced and released in water source are one of the most important factors leading to off-flavor emergencies and resident water consumption panic in drinking water.	Water	103-108	MIB E3 ubiquitin protein ligase 1	Homo sapiens	47-50
7720469-10	1995	These findings suggest that a major mediator of postprandial sodium and water absorption in the ileum is the Na+/H+ exchanger.	Water	72-77	solute carrier family 9 member A1	Canis lupus familiaris	109-125
27097462-1	2015	The odorous compounds of 2-methylisoborneol (2-MIB) and geosmin (GSM) heavily produced and released in water source are one of the most important factors leading to off-flavor emergencies and resident water consumption panic in drinking water.	Water	201-206	MIB E3 ubiquitin protein ligase 1	Homo sapiens	47-50
27097462-7	2015	Based on the above method, the target compounds in reservoir water, reservoir soil and tap water in a certain region of Liaoning Province were analyzed.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
7700352-0	1995	Evolution of water reservoirs on Mars from D/H ratios in the atmosphere and crust.	Water	13-18	methionyl-tRNA synthetase 1	Homo sapiens	33-37
26725393-0	2015	[Temporally Relationship between Renal Local Clock System and Circadian Rhythm of the Water Electrolyte Excretion].	Water	86-91	clock circadian regulator	Rattus norvegicus	45-50
26725393-8	2015	CONCLUSION: Urine volume and urine electrolyte excretion rate which displayed circadian pattern were temporally coupled with the rhythm of expression of clock and clock-controlled genes associated with water electrolyte transportation in rats kidney.	Water	202-207	clock circadian regulator	Rattus norvegicus	153-158
26725393-8	2015	CONCLUSION: Urine volume and urine electrolyte excretion rate which displayed circadian pattern were temporally coupled with the rhythm of expression of clock and clock-controlled genes associated with water electrolyte transportation in rats kidney.	Water	202-207	clock circadian regulator	Rattus norvegicus	163-168
7892234-2	1995	The protein was protoporphyrin IX-substituted myoglobin in a glycerol/water solvent.	Water	70-75	myoglobin	Homo sapiens	46-55
26254469-3	2015	To address this question, we used cysteine scanning mutagenesis to monitor aqueous accessibility of stalled translation intermediates to determine when, during biogenesis, hydrophilic peptide loops of the aquaporin-4 (AQP4) water channel are delivered to cytosolic and lumenal compartments.	Water	224-229	aquaporin 4	Homo sapiens	205-216
26254469-3	2015	To address this question, we used cysteine scanning mutagenesis to monitor aqueous accessibility of stalled translation intermediates to determine when, during biogenesis, hydrophilic peptide loops of the aquaporin-4 (AQP4) water channel are delivered to cytosolic and lumenal compartments.	Water	224-229	aquaporin 4	Homo sapiens	218-222
7742711-0	1995	Diurnal renal responses in man to water loading at sea level and 31 atm abs.	Water	34-39	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	51-54
26293614-8	2015	This interaction was also blocked by the anti-C3(H2O) and anti-CD11b monoclonal antibodies, indicating that C3(H2O) and CD11b are involved in tethering PMPs to PMNs.	Water	49-52	integrin subunit alpha M	Homo sapiens	120-125
26293614-8	2015	This interaction was also blocked by the anti-C3(H2O) and anti-CD11b monoclonal antibodies, indicating that C3(H2O) and CD11b are involved in tethering PMPs to PMNs.	Water	111-114	integrin subunit alpha M	Homo sapiens	63-68
26293614-9	2015	We confirmed the direct interaction between C3(H2O) and CD11b by quartz crystal microbalance analysis using purified native C3 and recombinant CD11b/CD18 and by flow cytometry using PMP and recombinant CD11b.	Water	47-50	integrin subunit alpha M	Homo sapiens	56-61
26293614-9	2015	We confirmed the direct interaction between C3(H2O) and CD11b by quartz crystal microbalance analysis using purified native C3 and recombinant CD11b/CD18 and by flow cytometry using PMP and recombinant CD11b.	Water	47-50	integrin subunit alpha M	Homo sapiens	143-148
26293614-9	2015	We confirmed the direct interaction between C3(H2O) and CD11b by quartz crystal microbalance analysis using purified native C3 and recombinant CD11b/CD18 and by flow cytometry using PMP and recombinant CD11b.	Water	47-50	integrin subunit alpha M	Homo sapiens	143-148
26293614-10	2015	Transfectants expressing CD11b/CD18 were also shown to specifically adhere to surface-bound C3(H2O).	Water	95-98	integrin subunit alpha M	Homo sapiens	25-30
7532304-4	1995	Recently, a molecular water channel (AQP-CD) has been cloned whose expression appears to be limited to the collecting duct.	Water	22-27	aquaporin 2	Rattus norvegicus	37-43
26293614-11	2015	We have identified contact-activated C3(H2O) as a novel ligand for CD11b/CD18 that mediates PPC formation and the binding of PMPs to PMNs.	Water	40-43	integrin subunit alpha M	Homo sapiens	67-72
7532304-6	1995	Here, we test the hypothesis that vasopressin increases cellular water permeability by inducing exocytosis of AQP-CD-laden vesicles, transferring water channels from IVs to APM.	Water	65-70	aquaporin 2	Rattus norvegicus	110-116
26344260-0	2015	A supramolecular structure insight for conversion property of cellulose in hot compressed water: Polymorphs and hydrogen bonds changes.	Water	90-95	alcohol dehydrogenase iron containing 1	Homo sapiens	75-78
7532304-11	1995	Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability.	Water	173-178	aquaporin 2	Rattus norvegicus	52-58
7532304-12	1995	We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.	Water	43-48	aquaporin 2	Rattus norvegicus	129-135
7532304-12	1995	We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.	Water	136-141	aquaporin 2	Rattus norvegicus	129-135
26764375-8	2016	An inactive PIP2;1 point mutation was identified that abrogated water and CO2 permeability and extracellular CO2 regulation of SLAC1 activity.	Water	64-69	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	12-18
24202141-1	1995	Using existing monitoring data, the present study attempts to characterize spatial patterns of surface water nutrients in the Baltic Sea.	Water	103-108	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	133-136
26576941-5	2016	In contrast, intra-VTA infusions of the CRF-R2 antagonist astressin2B non-specifically suppressed both EtOH and H2O drinking in the stressed group without effects in the non-stressed mice.	Water	112-115	corticotropin releasing hormone receptor 2	Mus musculus	40-46
26512424-0	2015	Control of the Aquaporin-4 Channel Water Permeability by Structural Dynamics of Aromatic/Arginine Selectivity Filter Residues.	Water	35-40	aquaporin 4	Homo sapiens	15-26
26512424-4	2015	Here we use measurements of the membrane water permeability of mammalian cells expressing AQP4 mutants to provide the first in vitro evidence in support of this hypothesis.	Water	41-46	aquaporin 4	Homo sapiens	90-94
26488924-3	2015	In this paper, a facile water-based solution method has been developed for the modification of nanostructured hematite photoanode with TiO2 overlayers using a water-soluble titanium complex (i.e., titanium bis(ammonium lactate) dihydroxide, TALH).	Water	24-29	transaldolase 1	Homo sapiens	241-245
26488924-3	2015	In this paper, a facile water-based solution method has been developed for the modification of nanostructured hematite photoanode with TiO2 overlayers using a water-soluble titanium complex (i.e., titanium bis(ammonium lactate) dihydroxide, TALH).	Water	159-164	transaldolase 1	Homo sapiens	241-245
7757005-0	1995	Structure and dynamics of the water around myoglobin.	Water	30-35	myoglobin	Homo sapiens	43-52
26067701-6	2015	Among the studied compounds, pentachlorophenol was detected in tap water at a concentration level of 0.06 microg L(-1).	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
7819239-4	1995	The observed stabilization of PEPC by specific salts has been interpreted in terms of the positive surface tension increment and the water-structuring effects conferred on the solution by the specific stabilizing reagents.	Water	133-138	MLO-like protein 4	Zea mays	30-34
26438244-1	2015	Alternative oxidase (AOX) is a diiron carboxylate protein present in all plants examined to date that couples the oxidation of ubiquinol with the reduction of oxygen to water.	Water	169-174	acyl-CoA oxidase 1	Homo sapiens	0-19
28871699-5	2016	Alcohol precipitation supernatant fraction, water insoluble fraction and 40% to 70% alcohol elution fraction could significantly inhibit thrombin activity.	Water	44-49	prothrombin	Oryctolagus cuniculus	137-145
7528708-5	1995	Therefore, in the present study, to investigate the pathogenic role of the water channel in water retention in liver cirrhosis, gene expression of AQP-CD in the kidney was evaluated in cirrhotic rats.	Water	75-80	aquaporin 2	Rattus norvegicus	147-153
26673696-2	2016	Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a catalytic role for Tyr126 and approach of the water nucleophile on the same side as the departing adenine base.	Water	171-176	mutY DNA glycosylase	Homo sapiens	45-49
26438244-1	2015	Alternative oxidase (AOX) is a diiron carboxylate protein present in all plants examined to date that couples the oxidation of ubiquinol with the reduction of oxygen to water.	Water	169-174	acyl-CoA oxidase 1	Homo sapiens	21-24
26529487-0	2015	Binding site identification and role of permanent water molecule of PIM-3 kinase: A molecular dynamics study.	Water	50-55	Pim-3 proto-oncogene, serine/threonine kinase	Homo sapiens	68-73
26700960-0	2016	Spin State as a Marker for the Structural Evolution of Nature"s Water-Splitting Catalyst.	Water	64-69	spindlin 1	Homo sapiens	0-4
8643385-5	1995	Octanol-H2O partitioning free energies of peptides which (i) straddle the proteolysis site, and (ii) form the "side" and "bottom" of the proposed "lid" were found to only slightly favor H2O, suggesting that the peptide is poised to detach from the less polar surface surrounding the RIP active site.	Water	8-11	ribosome-inactivating protein	Zea mays	283-286
26700960-2	2016	The tetramanganese-calcium cofactor that catalyzes biological water oxidation in photosystem II cycles through five catalytic intermediates, each of which adopts a specific geometric and electronic structure and is thus characterized by a specific spin state.	Water	62-67	spindlin 1	Homo sapiens	248-252
26700960-3	2016	Here, we review spin-structure correlations in Nature"s water-splitting catalyst.	Water	56-61	spindlin 1	Homo sapiens	16-20
26700960-12	2016	The ability of the Mn4O5Ca cofactor to adopt two distinct structural and spin-state forms in the S2 state is critical for water binding in the S3 state, allowing spin-state crossing from the inactive, low-spin configuration of the catalyst to the activated, high-spin configuration.	Water	122-127	spindlin 1	Homo sapiens	73-77
26700960-12	2016	The ability of the Mn4O5Ca cofactor to adopt two distinct structural and spin-state forms in the S2 state is critical for water binding in the S3 state, allowing spin-state crossing from the inactive, low-spin configuration of the catalyst to the activated, high-spin configuration.	Water	122-127	spindlin 1	Homo sapiens	162-166
25817821-7	2015	Probable cases were more likely than probable controls to drink tap water (adjusted odds ratio: 3.4; 95% CI: 1.2-9.2).	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
25817821-10	2015	Two tap water samples had detectable thermotolerant coliforms.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
26700960-12	2016	The ability of the Mn4O5Ca cofactor to adopt two distinct structural and spin-state forms in the S2 state is critical for water binding in the S3 state, allowing spin-state crossing from the inactive, low-spin configuration of the catalyst to the activated, high-spin configuration.	Water	122-127	spindlin 1	Homo sapiens	162-166
7810724-3	1994	Oral administration of the selective AVP V2 receptor antagonist OPC-31260 induced marked water diuresis, which resulted in significant increases in serum sodium concentration, plasma renin activity, and plasma concentration of AVP, although it did not produce hemodynamic improvement.	Water	89-94	arginine vasopressin	Canis lupus familiaris	37-40
26700960-12	2016	The ability of the Mn4O5Ca cofactor to adopt two distinct structural and spin-state forms in the S2 state is critical for water binding in the S3 state, allowing spin-state crossing from the inactive, low-spin configuration of the catalyst to the activated, high-spin configuration.	Water	122-127	spindlin 1	Homo sapiens	162-166
26586115-5	2016	These compounds also displayed different AIE performances: when the fraction of water in the THF solutions of these compounds was increased, we observed a significant improvement in the PhiF of compounds SAF-2-TriPE and SAF-3-TriPE; in contrast, compound SAF-4-TriPE showed an abnormal phenomenon, in that it emitted a strong fluorescence in both pure THF solution and in the aggregated state without a significant change in PhiF .	Water	80-85	sialic acid binding Ig like lectin 8	Homo sapiens	204-209
26323247-2	2015	In up to 80% of cases, NMO is associated with antibodies to aquaporin-4 (AQP4-IgG), the most abundant water channel in the CNS.	Water	102-107	aquaporin 4	Homo sapiens	60-71
26323247-2	2015	In up to 80% of cases, NMO is associated with antibodies to aquaporin-4 (AQP4-IgG), the most abundant water channel in the CNS.	Water	102-107	aquaporin 4	Homo sapiens	73-77
7810724-5	1994	These results suggest that AVP plays a significant role in elevation of vascular tone through V1 receptors and plays a major role in retaining free water through V2 receptors in this model of heart failure.	Water	148-153	arginine vasopressin	Canis lupus familiaris	27-30
26520739-6	2015	Furthermore, the image of the pure-water phantom showed almost the same distribution as the tap-water phantom, indicating that the luminescence image was not related to impurities in the water.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
7526388-0	1994	Cloning and expression of AQP3, a water channel from the medullary collecting duct of rat kidney.	Water	34-39	aquaporin 3 (Gill blood group)	Rattus norvegicus	26-30
26520739-6	2015	Furthermore, the image of the pure-water phantom showed almost the same distribution as the tap-water phantom, indicating that the luminescence image was not related to impurities in the water.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
26520739-9	2015	The luminescence images of the tap-water phantom during proton irradiation could be obtained in less than 2 s. CONCLUSIONS: Luminescence imaging during proton-beam irradiation is promising as an effective method for range estimation in proton therapy.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
26297688-0	2015	Mapping brain Fos immunoreactivity in response to water deprivation and partial rehydration: Influence of sodium intake.	Water	50-55	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-17
26297688-8	2015	In contrast, sodium intake further increased Fos-ir that was activated by water deprivation in the dorsal raphe nucleus, another inhibitory area localized in the hindbrain.	Water	74-79	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-48
26490534-5	2016	The molar distribution of adsorbable organic bromine to chlorine (AOBr/AOCl) for AOX in the groundwater distribution system was 1.5:1 and almost 1:1 for the surface water system.	Water	98-103	acyl-CoA oxidase 1	Homo sapiens	81-84
26636620-7	2016	Spatial maps of this second order term, for water in and around the synthetic host cucurbit[7]uril and in the binding pocket of the enzyme Factor Xa, reveal mainly negative contributions, indicating solute-induced water-water correlations relative to bulk water; particularly strong signals are obtained for sites at the entrances of cavities or pockets.	Water	44-49	coagulation factor X	Homo sapiens	139-148
26636620-7	2016	Spatial maps of this second order term, for water in and around the synthetic host cucurbit[7]uril and in the binding pocket of the enzyme Factor Xa, reveal mainly negative contributions, indicating solute-induced water-water correlations relative to bulk water; particularly strong signals are obtained for sites at the entrances of cavities or pockets.	Water	214-219	coagulation factor X	Homo sapiens	139-148
7526388-13	1994	The present study demonstrates the existence of an additional water channel, AQP3, in epithelial cells of the medullary collecting duct.	Water	62-67	aquaporin 3 (Gill blood group)	Rattus norvegicus	77-81
7765412-3	1994	Glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP+ 1-oxidoreductase, EC 1.1.1.49) from Bakers" yeast was immobilized with the highest activity on polyacrylamide beads possessing carboxylic functional groups activated by a water-soluble carbodiimide.	Water	235-240	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-33
26636620-7	2016	Spatial maps of this second order term, for water in and around the synthetic host cucurbit[7]uril and in the binding pocket of the enzyme Factor Xa, reveal mainly negative contributions, indicating solute-induced water-water correlations relative to bulk water; particularly strong signals are obtained for sites at the entrances of cavities or pockets.	Water	214-219	coagulation factor X	Homo sapiens	139-148
26636620-7	2016	Spatial maps of this second order term, for water in and around the synthetic host cucurbit[7]uril and in the binding pocket of the enzyme Factor Xa, reveal mainly negative contributions, indicating solute-induced water-water correlations relative to bulk water; particularly strong signals are obtained for sites at the entrances of cavities or pockets.	Water	214-219	coagulation factor X	Homo sapiens	139-148
26186865-10	2015	More than 200 measurements were recorded to define the map at each horizontal plane positioned at a different distance from the US transducer; tap water was heated at the same temperature used for dyeing tests (60 C).	Water	147-152	nuclear RNA export factor 1	Homo sapiens	143-146
26841530-0	2015	[The external application of "Plastunskaya" fluoride-containing mineral water in the course of the combined spa and health resort-based treatment of deforming osteoarthrosis].	Water	72-77	surfactant protein A2	Homo sapiens	108-111
7879705-3	1994	EAU was induced by the injection of retinal S-antigen (S-Ag) into the foot-pad of Lewis rats.	Water	0-3	S-antigen visual arrestin	Rattus norvegicus	36-53
26516885-0	2015	Indoor Heating Drives Water Bacterial Growth and Community Metabolic Profile Changes in Building Tap Pipes during the Winter Season.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	97-100
26607027-1	2016	The activity of Au nanoparticle-loaded P25 TiO2 (Au/P25) plasmonic photocatalysts, evaluated by the oxidative decomposition of formic acid in water under visible light irradiation, was enhanced up to 3 times by simply mixing Au/P25 with photocatalytically inactive h-BN nanosheets as a result of electron transfer from photoexcited Au/TiO2 to the h-BN nanosheets and retardation of the charge recombination.	Water	142-147	tubulin polymerization promoting protein	Homo sapiens	49-55
26607027-1	2016	The activity of Au nanoparticle-loaded P25 TiO2 (Au/P25) plasmonic photocatalysts, evaluated by the oxidative decomposition of formic acid in water under visible light irradiation, was enhanced up to 3 times by simply mixing Au/P25 with photocatalytically inactive h-BN nanosheets as a result of electron transfer from photoexcited Au/TiO2 to the h-BN nanosheets and retardation of the charge recombination.	Water	142-147	tubulin polymerization promoting protein	Homo sapiens	225-231
7879705-3	1994	EAU was induced by the injection of retinal S-antigen (S-Ag) into the foot-pad of Lewis rats.	Water	0-3	S-antigen visual arrestin	Rattus norvegicus	55-59
26489685-1	2015	Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the central nervous system.	Water	38-43	aquaporin 4	Mus musculus	0-11
26489685-1	2015	Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the central nervous system.	Water	38-43	aquaporin 4	Mus musculus	13-17
26955487-6	2016	Our results indicate that GPR30 expression increased in breast cancer cells at levels lower than the US EPA drinking water contamination limit.	Water	117-122	G protein-coupled estrogen receptor 1	Homo sapiens	26-31
7522327-2	1994	We have previously shown that AQP-CD is present in the apical plasma membrane and subapical vesicles of collecting duct cells, consistent with membrane-shuttling mechanisms that have been proposed to explain the short-term action of [Arg8] vasopressin (AVP) to regulate apical water permeability.	Water	277-282	aquaporin 2	Rattus norvegicus	30-36
26825228-10	2016	Second, the E2f4f/f;E2f5+/-;Vil-cre efferent ducts had completely lost multiciliated cells and greatly reduced levels of critical absorptive cell proteins: aquaporin1, a water channel protein, and clusterin, an endocytic marker.	Water	170-175	villin 1	Mus musculus	28-31
26268558-6	2015	Neutron scattering indicated similar Rg values and P(r) curves, although IgA1 showed a propensity to aggregate in heavy water buffer.	Water	120-125	immunoglobulin heavy constant alpha 1	Homo sapiens	73-77
7522327-3	1994	We propose here that AVP may also have long-term actions on the collecting duct to regulate the expression of the AQP-CD water channel.	Water	121-126	aquaporin 2	Rattus norvegicus	114-120
7522327-9	1994	Based on these findings, we conclude that (i) long-term infusion of AVP, acting either directly or indirectly, regulates expression of the AQP-CD water channel and (ii) AQP-CD is the predominant AVP-regulated water channel.	Water	146-151	aquaporin 2	Rattus norvegicus	139-145
7522327-9	1994	Based on these findings, we conclude that (i) long-term infusion of AVP, acting either directly or indirectly, regulates expression of the AQP-CD water channel and (ii) AQP-CD is the predominant AVP-regulated water channel.	Water	209-214	aquaporin 2	Rattus norvegicus	139-145
7522327-9	1994	Based on these findings, we conclude that (i) long-term infusion of AVP, acting either directly or indirectly, regulates expression of the AQP-CD water channel and (ii) AQP-CD is the predominant AVP-regulated water channel.	Water	209-214	aquaporin 2	Rattus norvegicus	169-175
26463008-4	2015	The astrocyte networks are connected through aquaporin-4 (AQP4) water channels with a parallel, extracellular route carrying metabolites.	Water	64-69	aquaporin 4	Homo sapiens	45-56
26463008-4	2015	The astrocyte networks are connected through aquaporin-4 (AQP4) water channels with a parallel, extracellular route carrying metabolites.	Water	64-69	aquaporin 4	Homo sapiens	58-62
26705758-2	2016	The spectrum of the disease has expanded based on the specificity of the autoimmune response to the aquaporin-4 water channel on astrocytes.	Water	112-117	aquaporin 4	Homo sapiens	100-111
8084283-1	1994	Injection of rats with the beta 2-adrenoceptor agonist clenbuterol (1 mg/kg/d for 15 days) stimulated an increase in body weight (9%) and protein (8%) and water (7%) content, but reduced food intake (4%) and epididymal fat pad mass (39%).	Water	155-160	adrenoceptor beta 2	Rattus norvegicus	27-46
26528456-11	2015	CONCLUSION: In preterm infants on bubble CPAP with set pressures of 4-6 cm H2O, a fixed flow of 5 L/min is more effective than a flow titrated to ensure adequate visible bubbling.	Water	75-78	centromere protein J	Homo sapiens	41-45
26368315-7	2015	Followed by fast initial membrane association, structural reorganization of alpha-helical segments of PLA2 takes place at the lipid water interface.	Water	132-137	phospholipase A2 group IIA	Homo sapiens	102-106
28025598-12	2016	The main water sources of the town were tap water within the yard, which was estimated to be 44.7%, and tap water in the community was 40.0% followed by private protected well which was 14.5%.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	40-43
7520873-2	1994	A molecular model of LIF has been constructed based mainly on the structure of the related cytokine granulocyte colony-stimulating factor, and refined using simulated annealing and molecular dynamics in water.	Water	203-208	LIF interleukin 6 family cytokine	Homo sapiens	21-24
27057365-2	2016	Aquaporin-4 (AQP4), which is primarily expressed in astrocytes, is the major water channel expressed in the central nervous system (CNS).	Water	77-82	aquaporin 4	Homo sapiens	0-11
27057365-2	2016	Aquaporin-4 (AQP4), which is primarily expressed in astrocytes, is the major water channel expressed in the central nervous system (CNS).	Water	77-82	aquaporin 4	Homo sapiens	13-17
26100336-3	2015	Aquaporin-4 (AQP4) and Aquaporin-9 (AQP9) play an important role in maintaining brain water homeostasis under various conditions.	Water	86-91	aquaporin 4	Homo sapiens	0-11
26100336-3	2015	Aquaporin-4 (AQP4) and Aquaporin-9 (AQP9) play an important role in maintaining brain water homeostasis under various conditions.	Water	86-91	aquaporin 4	Homo sapiens	13-17
7922152-2	1994	The Adriatic Sea, as semienclosed body of water, is of special interest for an evaluation of the entry, extent and fate of the pollution by chlorinated hydrocarbons.	Water	42-47	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	13-16
26437931-9	2015	RESULT: Only 18.1% (43/237) of the study population had access to tap water in the study area.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
26437931-13	2015	Accordingly, FC were detected in 80% of the total samples with counts ranging between 0.67 and 266.67 CFU/100 ml although 66.67% of tap water samples were negative for FC.	Water	136-141	nuclear RNA export factor 1	Homo sapiens	132-135
28427055-1	2016	OBJECTIVE: Aquaporin-4 (AQP4), a key molecule for water homeostasis in the brain, is associated with adult neurogenesis, but its mechanisms regulating adult neural stem cells (aNSC) remain largely unexplored.	Water	50-55	aquaporin 4	Mus musculus	11-22
28427055-1	2016	OBJECTIVE: Aquaporin-4 (AQP4), a key molecule for water homeostasis in the brain, is associated with adult neurogenesis, but its mechanisms regulating adult neural stem cells (aNSC) remain largely unexplored.	Water	50-55	aquaporin 4	Mus musculus	24-28
8035326-9	1994	From the spectrum of its change with concentration, calculated values for a corresponding apparent Vmax and Km were 17.5 nmol sec-1 ml-1 cellular water and 27 microM, respectively.	Water	146-151	secretory blood group 1	Rattus norvegicus	126-131
27925711-6	2016	The testing was conducted according to the method based on conditions of dynamic flow of tap water.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
26605175-3	2015	Artificial tap water was thickened to honey-like consistency (effective viscosity of 1,300+-100 mPa s at a shear rate of 50 per second at 20C) with a starch-based thickener (SB) or a gum-containing thickener (GC).	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
26985408-7	2015	Water was taken from two sources, tap water, and from the water filter.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	34-37
26985408-10	2015	RESULTS: The number of water samples found to be within desirable limits with respect to physicochemical parameters were significantly more with the filter water sample than the tap water samples.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	178-181
27232415-1	2016	The genotoxicity of water and sediment samples from stormwater treatment systems and water from urban highway runoff was tested in the Salmonella/microsome assays with Salmonella typhimurium, micronucleus assay (Trad-MN) with plants and with human-derived liver cells (HepG2), or comet assay with HepG2.	Water	20-25	TraD	Salmonella enterica subsp. enterica serovar Typhimurium	212-216
26985408-11	2015	Suspicious/unsatisfactory microbiological quality of water was observed in 28% and 4% of tap and filter water samples, respectively.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	89-92
7973817-4	1994	The extent of heat shock protein 70 messenger RNA accumulated in ASMC was higher in SHR than in WKY rats when the cells were heated by immersing the culture bottles in 42 degrees C water bath for 15 min and allowed to recover at 37 degrees C for 2 h. In contrast with WKY rats, the Bam HI restricted bepatic DNA showed that a fragment about 5.6 kb was lost in heat shock protein 70 gene from hepatic DNA of SHR.	Water	181-186	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	14-35
26216045-4	2015	In contrast, dectin-1 is critically involved in the development of CFA-mediated EAU.	Water	80-83	C-type lectin domain family 7, member a	Mus musculus	13-21
26216045-7	2015	Thus dectin-1 plays a critical role in the ability of complete Freund"s adjuvant to induce EAU in mice.	Water	91-94	C-type lectin domain family 7, member a	Mus musculus	5-13
27386983-0	2016	Flocculation kinetics mechanism and floc formation prepared by poly aluminum chloride coupled with polyacrylamide for ship ballast water.	Water	131-136	inositol polyphosphate-5-phosphatase D	Homo sapiens	118-122
7916878-12	1994	S. mbandaka) in sewage works, drainage canals and the North Sea reveal the problem involved in evaluating such finds in bathing water samples, because in EEC regulations no differentiation or quantification is made.	Water	128-133	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	60-63
26734024-5	2015	The expression of AtHXK1 in the guard cells of citrus reduced stomatal conductance and transpiration with no negative effect on the rate of photosynthesis, leading to increased water-use efficiency.	Water	177-182	hexokinase 1	Arabidopsis thaliana	18-24
26424896-2	2015	Here, we show that such processes might involve synergistic cooperation between the glial water channel aquaporin 4 (AQP4) and the transient receptor potential isoform 4 (TRPV4), a polymodal swelling-sensitive cation channel.	Water	90-95	aquaporin 4	Mus musculus	104-115
7513595-6	1994	In the presence of the NK1 receptor antagonist, the capsaicin response was not diminished, but in the presence of the NK2 receptor antagonist, the Pao response diminished to only 10 +/- 2 cm H2O, p &lt; 0.001.	Water	191-194	substance-K receptor	Cavia porcellus	118-130
26424896-2	2015	Here, we show that such processes might involve synergistic cooperation between the glial water channel aquaporin 4 (AQP4) and the transient receptor potential isoform 4 (TRPV4), a polymodal swelling-sensitive cation channel.	Water	90-95	aquaporin 4	Mus musculus	117-121
26424896-11	2015	We conclude that AQP4-mediated water fluxes promote the activation of the swelling sensor, whereas Ca(2+) entry through TRPV4 channels reciprocally modulates volume regulation, swelling, and Aqp4 gene expression.	Water	31-36	aquaporin 4	Mus musculus	17-21
26424896-12	2015	Therefore, TRPV4-AQP4 interactions constitute a molecular system that fine-tunes astroglial volume regulation by integrating osmosensing, calcium signaling, and water transport and, when overactivated, triggers pathological swelling.	Water	161-166	aquaporin 4	Mus musculus	17-21
26424896-13	2015	Significance statement: We characterize the physiological features of interactions between the astroglial swelling sensor transient receptor potential isoform 4 (TRPV4) and the aquaporin 4 (AQP4) water channel in retinal Muller cells.	Water	196-201	aquaporin 4	Mus musculus	177-188
26424896-13	2015	Significance statement: We characterize the physiological features of interactions between the astroglial swelling sensor transient receptor potential isoform 4 (TRPV4) and the aquaporin 4 (AQP4) water channel in retinal Muller cells.	Water	196-201	aquaporin 4	Mus musculus	190-194
26424896-15	2015	Specifically, water influx through AQP4 drives calcium influx via TRPV4 in the glial end foot, which regulates expression of Aqp4 and Kir4.1 genes and facilitates the time course and amplitude of hypotonicity-induced swelling and regulatory volume decrease.	Water	14-19	aquaporin 4	Mus musculus	35-39
26424896-15	2015	Specifically, water influx through AQP4 drives calcium influx via TRPV4 in the glial end foot, which regulates expression of Aqp4 and Kir4.1 genes and facilitates the time course and amplitude of hypotonicity-induced swelling and regulatory volume decrease.	Water	14-19	aquaporin 4	Mus musculus	125-129
26423860-8	2015	When rats underwent water restriction for 72 h, mRNA levels of SGLT1a increased in ATLs, NaGLT1 levels increased in both ATLs and DTLs, and UT-A2c increased in ATLs.	Water	20-25	solute carrier family 5 member 1	Rattus norvegicus	63-69
26423860-8	2015	When rats underwent water restriction for 72 h, mRNA levels of SGLT1a increased in ATLs, NaGLT1 levels increased in both ATLs and DTLs, and UT-A2c increased in ATLs.	Water	20-25	Na+ dependent glucose transporter 1	Rattus norvegicus	89-95
26462923-6	2015	The experiment results revealed that the SiO2@FMIP was satisfactory as a recognition element for determination of LC in soda water samples.	Water	125-130	THO complex 5	Homo sapiens	41-50
7920450-6	1994	In addition, it was shown that the AUC, as well as the absorption in the intestinal loop, was decreased for a MFGM emulsion in which the droplet size was reduced by sonication, presumably because of the observed decrease in alpha-linolenic acid concentration in the water phase, which was assumed to be the result of an increased distribution of alpha-linolenic acid, due to its amphipathic nature, to the increased oil-water interface.	Water	266-271	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	110-114
26677259-1	2015	The present study tested the hypothesis that zebrafish (Danio rerio) aquaporin-1a1 (AQP1a1) serves as a multi-functional channel for the transfer of the small gaseous molecules, CO2 and ammonia, as well as water, across biological membranes.	Water	206-211	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	69-82
26677259-1	2015	The present study tested the hypothesis that zebrafish (Danio rerio) aquaporin-1a1 (AQP1a1) serves as a multi-functional channel for the transfer of the small gaseous molecules, CO2 and ammonia, as well as water, across biological membranes.	Water	206-211	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	84-90
26677259-3	2015	Knockdown of AQP1a1 significantly reduced rates of CO2 and ammonia excretion, as well as water fluxes, in larvae at 4 days post fertilization (dpf).	Water	89-94	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	13-19
26385393-6	2015	It is possible that overexpression of AQP4 results in a rapid and increased influx of osmotic water across the plasma membrane into cells, thereby inducing cell swelling and cerebral edema.	Water	94-99	aquaporin 4	Homo sapiens	38-42
26150471-4	2015	Surprisingly, the strongest signal was detected in broth medium without bacterial cells present and it was mitigated by iron chelation or by addition of catalase, which catalyzes the decomposition of hydrogen peroxide to water and oxygen.	Water	221-226	AT695_RS10915	Staphylococcus aureus	153-161
7920450-6	1994	In addition, it was shown that the AUC, as well as the absorption in the intestinal loop, was decreased for a MFGM emulsion in which the droplet size was reduced by sonication, presumably because of the observed decrease in alpha-linolenic acid concentration in the water phase, which was assumed to be the result of an increased distribution of alpha-linolenic acid, due to its amphipathic nature, to the increased oil-water interface.	Water	420-425	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	110-114
7512499-11	1994	The administration of GH or IGF-I to GHD rats resulted in significant increases in weight gained, although food and water intake remained unaltered.	Water	116-121	insulin-like growth factor 1	Rattus norvegicus	28-33
25592266-8	2015	Of participants aged &lt;20 years, seropositivity was significantly associated with having a well as the source of home tap water (aOR 1 7, 95% CI 1 1-2 6) and living in a more crowded home (aOR 2 3, 95% CI 1 5-3 7).	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
25630715-1	2015	Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface.	Water	38-43	aquaporin 4	Homo sapiens	0-11
25630715-1	2015	Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface.	Water	38-43	aquaporin 4	Homo sapiens	13-17
25630715-4	2015	Phosphorylation-dependent gating of AQP4 has been proposed as a regulatory mechanism for AQP4-mediated osmotic water transport.	Water	111-116	aquaporin 4	Homo sapiens	36-40
25630715-4	2015	Phosphorylation-dependent gating of AQP4 has been proposed as a regulatory mechanism for AQP4-mediated osmotic water transport.	Water	111-116	aquaporin 4	Homo sapiens	89-93
7961601-5	1994	The scattering profiles were analyzed by simulation of hydrated ras p21, based on the crystal atomic coordinates, and it was concluded that the ras p21 molecule incorporates 20% more bulk water upon GTP binding.	Water	188-193	H3 histone pseudogene 16	Homo sapiens	148-151
26208470-0	2015	Regulation of the perilymphatic-endolymphatic water shunt in the cochlea by membrane translocation of aquaporin-5.	Water	46-51	aquaporin 5	Mus musculus	102-113
26208470-9	2015	Finally, the water shunt elements AQP4, AQP5, and M3R were also demonstrated in OSCs of the human cochlea.	Water	13-18	aquaporin 4	Homo sapiens	34-38
25372987-0	2015	An insight to the conserved water mediated dynamics of catalytic His88 and its recognition to thyroxin and RBP binding residues in human transthyretin.	Water	28-33	retinol binding protein 4	Homo sapiens	107-110
26121313-17	2015	Altogether PGE2 acting on EP1 and EP4 receptors may prove to be important mediators of PT injury, and salt and water transport.	Water	111-116	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	34-37
26208470-10	2015	The regulation of the AQP4/AQP5 water shunt in OSCs of the cochlear apex provides a molecular basis for regulated endolymphatic volume homeostasis.	Water	32-37	aquaporin 4	Mus musculus	22-26
26208470-10	2015	The regulation of the AQP4/AQP5 water shunt in OSCs of the cochlear apex provides a molecular basis for regulated endolymphatic volume homeostasis.	Water	32-37	aquaporin 5	Mus musculus	27-31
8046774-1	1994	Met5-enkephalin inhibits sodium and water excretion and antagonizes the central actions of angiotensin II in subfornical organ of rat brain.	Water	36-41	proenkephalin	Rattus norvegicus	5-15
26327442-5	2015	Downregulated expression of Anks3 in vivo in mice by Locked Nucleic Acid (LNA) modified antisense oligonucleotides was associated with increased transcription of vasopressin-induced genes, suggesting changes in renal water permeability, and altered transcription of genes encoding proteins involved in cilium structure, apoptosis and cell proliferation.	Water	217-222	ankyrin repeat and sterile alpha motif domain containing 3	Mus musculus	28-33
26328838-5	2015	These intrinsic potentials are employed together with existing ones for H2, H2O, and (H2O)2, to obtain full PESs for H2(H2O) and H2(H2O)2.	Water	76-79	relaxin 2	Homo sapiens	117-123
26585511-1	2015	Aquaporin 4 (AQP4) is a transmembrane protein from the aquaporin family and is the predominant water channel in the mammalian brain.	Water	95-100	aquaporin 4	Homo sapiens	0-11
8140421-0	1994	Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine.	Water	27-32	aquaporin 2	Homo sapiens	41-52
26585511-1	2015	Aquaporin 4 (AQP4) is a transmembrane protein from the aquaporin family and is the predominant water channel in the mammalian brain.	Water	95-100	aquaporin 4	Homo sapiens	13-17
26585511-3	2015	In this work, based on data obtained from in silico and in vitro studies, a pH sensitivity that regulates the osmotic water permeability of AQP4 is demonstrated.	Water	118-123	aquaporin 4	Homo sapiens	140-144
26585511-4	2015	The results indicate that AQP4 has increased water permeability at conditions of low pH in atomistic computer simulations and experiments carried out on Xenopus oocytes expressing AQP4.	Water	45-50	aquaporin 4 L homeolog	Xenopus laevis	26-30
26585511-6	2015	A mutant form of AQP4, in which H95 was replaced with an alanine (H95A), loses sensitivity to cytoplasmic pH changes in in vitro osmotic water permeability, thereby substantiating the in silico work.	Water	137-142	aquaporin 4	Homo sapiens	17-21
26328838-5	2015	These intrinsic potentials are employed together with existing ones for H2, H2O, and (H2O)2, to obtain full PESs for H2(H2O) and H2(H2O)2.	Water	76-79	relaxin 2	Homo sapiens	129-135
26328838-5	2015	These intrinsic potentials are employed together with existing ones for H2, H2O, and (H2O)2, to obtain full PESs for H2(H2O) and H2(H2O)2.	Water	86-89	relaxin 2	Homo sapiens	117-123
26328838-5	2015	These intrinsic potentials are employed together with existing ones for H2, H2O, and (H2O)2, to obtain full PESs for H2(H2O) and H2(H2O)2.	Water	86-89	relaxin 2	Homo sapiens	129-135
26328838-7	2015	These PESs together with an existing one for water clusters are used in a many-body representation of the PES of hydrogen clathrate hydrates, illustrated for H2@(H2O)20.	Water	45-50	relaxin 2	Homo sapiens	158-168
26322121-8	2015	CONCLUSIONS: Due to acceptable recoveries (93.3-102.0 %) and RSD values (6-7.1) from spiked tap water, the developed method can be successfully applied for the determination of trace amounts of terbium ions in the presence of major components of water.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
8133054-6	1994	We report that in a fluid phase system, SAP inhibited degradation of C4(H2O) (which is C4b-like) in a dose-dependent manner.	Water	72-75	amyloid P component, serum	Homo sapiens	40-43
26599790-10	2015	It was also significantly lower among peoples who used tap water as source of drinking water than from Wells/river (OR 9.67, P = 0.03).	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
26599790-10	2015	It was also significantly lower among peoples who used tap water as source of drinking water than from Wells/river (OR 9.67, P = 0.03).	Water	87-92	nuclear RNA export factor 1	Homo sapiens	55-58
26298139-7	2015	A comparison with previous MD simulation studies of SPC/E and ST2 water as well as experiments indicates that, overall, the TIP4P/2005 model performs better than the SPC/E and ST2 models.	Water	66-71	ST2	Homo sapiens	62-65
8133054-7	1994	Phosphorylethanolamine was found to alleviate the inhibitory effect of SAP on C4(H2O) degradation.	Water	81-84	amyloid P component, serum	Homo sapiens	71-74
8133054-8	1994	Because this compound is known to inhibit the SAP-C4BP interaction, this indicated direct binding of SAP to C4BP to be required for inhibition of C4(H2O) degradation.	Water	149-152	amyloid P component, serum	Homo sapiens	46-49
8133054-8	1994	Because this compound is known to inhibit the SAP-C4BP interaction, this indicated direct binding of SAP to C4BP to be required for inhibition of C4(H2O) degradation.	Water	149-152	amyloid P component, serum	Homo sapiens	101-104
26193334-4	2015	Here, we conjugated a versatile low molecular weight TLR7 ligand to various polysaccharides in order to improve its water solubility, enhance its potency, and maintain low toxicity.	Water	116-121	toll-like receptor 7	Mus musculus	53-57
26588566-7	2015	Our study captures the process of water-favored LC3 protein recruitment to the membrane and thus opens, to our knowledge, new avenues to explore the cellular dynamics underlying vesicular trafficking.	Water	34-39	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	48-51
8294421-5	1994	The molecular weight of phosphodiester alpha-GlcNAcase is 204,950, as determined from density gradient centrifugation in D2O and H2O glycerol gradients and gel filtration.	Water	129-132	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	Bos taurus	24-54
26303625-3	2015	In 2004, however, Lennon and colleagues described a novel autoantibody in NMO which targets aquaporin-4, the most abundant water channel in the CNS, and which was later shown to be directly pathogenic.	Water	123-128	aquaporin 4	Homo sapiens	92-103
26287615-3	2015	In this study, we hypothesized that zebrafish AQP1a.1 is involved in the acid secretion by ionocytes through facilitating H2O and CO2 diffusion.	Water	122-125	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	46-53
7976661-3	1994	Mepyramine and ranitidine given 2 h before the induction of EBP prevented the accumulation of water, sodium and albumin in samples taken from the parietal cortex.	Water	94-99	EBP, cholestenol delta-isomerase	Rattus norvegicus	60-63
26247603-10	2015	There are human-specific changes in the sequence of the promoter and the protein-coding sequence of uridine diphosphoglucuronosyltransferase 1 (UGT1A1), the enzyme that transforms bilirubin and toxic plant compounds into water-soluble, excretable metabolites.	Water	221-226	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	144-150
26338873-7	2015	AQP6vs, AQP2 and/or AQP6ub are also expressed in these epithelial cells and are translocated to the apical membrane in response to arginine vasotocin, thereby regulating water absorption/reabsorption.	Water	170-175	aquaporin 2	Xenopus tropicalis	8-12
26547155-3	2015	However, we find numerical instability, which is manifested as an accumulation in the auxiliary velocity variables, that in turn results in an unacceptable increase in the number of SCF cycles to meet even loose convergence tolerances for the real induced dipoles over the course of a 1 ns trajectory of the AMOEBA14 water model.	Water	317-322	KIT ligand	Homo sapiens	182-185
8243640-3	1993	Subsequent amylin administration increased the rate of appearance of tritiated water 6.4-fold, consistent with stimulation of glycogenolysis and passage of the released moieties through the hexose --&gt; triose step of glycolysis.	Water	79-84	islet amyloid polypeptide	Rattus norvegicus	11-17
26526066-2	2015	Recent studies showed that the water channel aquaporin-4 (AQP4) mediates soluble Abeta clearance from the brain parenchyma along the paravascular pathway.	Water	31-36	aquaporin 4	Mus musculus	58-62
26246329-8	2015	Pluronic micelles (P85, F88, L35, and P123) effectively encapsulated gossypol, raising its water solubility by more than 1000-fold.	Water	91-96	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	19-22
26010686-13	2015	Administration of rat recombinant progranulin decreased brain water content and improved neurologic functions at both 24 and 72 hours after subarachnoid hemorrhage, while knockdown of endogenous progranulin aggravated neurologic deficits after subarachnoid hemorrhage.	Water	62-67	granulin precursor	Rattus norvegicus	34-45
8218280-0	1993	Water structural changes in lumirhodopsin, metarhodopsin I, and metarhodopsin II upon photolysis of bovine rhodopsin: analysis by Fourier transform infrared spectroscopy.	Water	0-5	rhodopsin	Bos taurus	32-41
25930667-3	2015	Endogenous GC-C agonists - guanylin peptides: guanylin and uroguanylin, by the regulation of water and electrolyte transport, are involved in the maintenance of homeostasis in the intestines and integrity of the intestinal mucosa.	Water	93-98	guanylate cyclase activator 2B	Homo sapiens	59-70
7764253-0	1993	Effect of water-miscible organic solvents on the catalytic activity of cytochrome c.	Water	10-15	cytochrome c, somatic	Equus caballus	71-83
26000774-1	2015	INTRODUCTION: Aquaporin-4 (AQP4) is the prominent water-channel protein in the brain playing a critical role in controlling cell water content.	Water	50-55	aquaporin 4	Homo sapiens	14-25
26000774-1	2015	INTRODUCTION: Aquaporin-4 (AQP4) is the prominent water-channel protein in the brain playing a critical role in controlling cell water content.	Water	50-55	aquaporin 4	Homo sapiens	27-31
26527142-0	2015	The putative role of some conserved water molecules in the structure and function of human transthyretin.	Water	36-41	transthyretin	Homo sapiens	91-104
26527142-3	2015	Extensive analyses of 32 high-resolution X-ray and neutron diffraction structures of hTTR followed by molecular-dynamics simulation studies using a set of 15 selected structures affirmed the presence of 44 conserved water molecules in its dimeric structure.	Water	216-221	transthyretin	Homo sapiens	85-89
26527142-8	2015	Some other water molecules control the orientation and dynamics of different structural elements of hTTR.	Water	11-16	transthyretin	Homo sapiens	100-104
26527142-10	2015	The present study may also provide some rational clues about the conserved water-mediated architecture and stability of hTTR.	Water	75-80	transthyretin	Homo sapiens	120-124
8405449-1	1993	A new b-type cytochrome, termed cytochrome b560 according to the wavelength maximum of its alpha-band in the reduced minus oxidized difference spectrum, was isolated from eggs of whitefish and partially purified by fractionation of the water-soluble moiety of yolk.	Water	236-241	CYTB	Coregonus lavaretus	32-44
26601838-0	2015	Redistribution of Proximal and Distal Reabsorption of Water and Ions in Rat Kidney After Treatment with Glucagon-Like Peptide-1 Mimetic.	Water	54-59	glucagon	Rattus norvegicus	104-127
26601838-1	2015	Injection of a glucagon-like peptide-1 mimetic accelerated recovery of the initial status of water-salt balance in rats after water or saline load (2.5% NaCl).	Water	93-98	glucagon	Rattus norvegicus	15-38
26601838-4	2015	The expected values corresponded to experimental results, which confirmed our hypothesis on the physiological mechanism for the involvement of the kidneys in the homeostatic effect of glucagon-like peptide-1 under variations in water-salt balance.	Water	228-233	glucagon	Rattus norvegicus	184-207
25973582-7	2015	Rapid formation was observed between 10  C and 30  C, as well as between pH 3 and pH 11, in both ultrapure and tap water, even at trace quantities of reactants (ng/L-range for metformin, mg/L-range for free chlorine).	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
25973582-8	2015	While Y is degraded within a few hours to days in the presence of light, elevated temperature, organic solvents and matrix constituents within tap water, a secondary degradation product was discovered, which is stable and colorless (C; C4H6ClN3).	Water	147-152	nuclear RNA export factor 1	Homo sapiens	143-146
26279619-3	2015	Aquaporin-1 (AQP1) and aquaporin-4 (AQP4) are water transport proteins that are highly expressed in primary glial-derived tumors.	Water	46-51	aquaporin 4	Homo sapiens	23-34
26279619-3	2015	Aquaporin-1 (AQP1) and aquaporin-4 (AQP4) are water transport proteins that are highly expressed in primary glial-derived tumors.	Water	46-51	aquaporin 4	Homo sapiens	36-40
8241386-5	1993	Our interpretation is that the cytochrome c-cytochrome b5 complex excludes water.	Water	75-80	cytochrome b5 type A	Homo sapiens	44-57
26925223-7	2015	Analysis of c-Fos labeling (functional changes) revealed developmentally-dependent increases in c-Fos positive cells in the dentate gyrus, CA3 and CA1 regions whereas training-dependent increases were noted in the CA3 and CA1 regions for the water-maze trained groups.	Water	242-247	carbonic anhydrase 3	Rattus norvegicus	214-217
26277716-4	2015	The water dispersibility test of Ptx-Pep prepared using different fractions of Pep demonstrated that a fraction (Pep-A), containing relatively hydrophobic peptides with high molecular weights, was effective in enhancing the water dispersibility of Ptx.	Water	4-9	carnosine dipeptidase 2	Homo sapiens	113-118
26277716-4	2015	The water dispersibility test of Ptx-Pep prepared using different fractions of Pep demonstrated that a fraction (Pep-A), containing relatively hydrophobic peptides with high molecular weights, was effective in enhancing the water dispersibility of Ptx.	Water	224-229	carnosine dipeptidase 2	Homo sapiens	113-118
26277716-6	2015	The water dispersibility of the complex between Ptx and Pep-A (Ptx-Pep-A) was independent of pH, even though it is positively or negatively charged under strongly acidic and neutral conditions.	Water	4-9	carnosine dipeptidase 2	Homo sapiens	56-61
26277716-6	2015	The water dispersibility of the complex between Ptx and Pep-A (Ptx-Pep-A) was independent of pH, even though it is positively or negatively charged under strongly acidic and neutral conditions.	Water	4-9	carnosine dipeptidase 2	Homo sapiens	63-72
8395331-5	1993	Direct injection of the tk gene under control of the tyrosinase promoter into established tumors in mice, followed by treatment with ganciclovir, led to significant reductions in resultant tumor size relative to the size of tumor developing in mice treated with water (median tumor weight, 1.65 g versus 2.75 g).	Water	262-267	tyrosinase	Mus musculus	53-63
25704766-5	2015	Extracellular acidosis in turn produces inhibition of aquaporin-4 (AQP-4) located at the end feet of pericapillary astrocytes, the water channel which regulates water influx into the pericapillary space and, hence, interstitial flow.	Water	131-136	aquaporin 4	Homo sapiens	54-65
25704766-5	2015	Extracellular acidosis in turn produces inhibition of aquaporin-4 (AQP-4) located at the end feet of pericapillary astrocytes, the water channel which regulates water influx into the pericapillary space and, hence, interstitial flow.	Water	131-136	aquaporin 4	Homo sapiens	67-72
25704766-5	2015	Extracellular acidosis in turn produces inhibition of aquaporin-4 (AQP-4) located at the end feet of pericapillary astrocytes, the water channel which regulates water influx into the pericapillary space and, hence, interstitial flow.	Water	161-166	aquaporin 4	Homo sapiens	54-65
25704766-5	2015	Extracellular acidosis in turn produces inhibition of aquaporin-4 (AQP-4) located at the end feet of pericapillary astrocytes, the water channel which regulates water influx into the pericapillary space and, hence, interstitial flow.	Water	161-166	aquaporin 4	Homo sapiens	67-72
26529487-9	2015	Induction of water molecules during molecular docking simulation explored differences in the hinge region between PIM-1 and PIM-3 kinases that may be responsible for specificity.	Water	13-18	Pim-3 proto-oncogene, serine/threonine kinase	Homo sapiens	124-129
26111855-4	2015	Interestingly, for the CO response at 350  C, Pd-SnO2 with small Pd size showed almost constant sensor response with varying humidity (0.5-4 vol % H2O).	Water	147-150	strawberry notch homolog 2	Homo sapiens	49-52
26111855-5	2015	While the CO response of Pd-SnO2 with large Pd size even increased with increasing amount of water vapor.	Water	93-98	strawberry notch homolog 2	Homo sapiens	28-31
26030158-0	2015	Real-time detection of hypochlorite in tap water and biological samples by a colorimetric, ratiometric and near-infrared fluorescent turn-on probe.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
7895247-6	1993	Fab interactions with extended hapten on the membrane were similar to interactions with water-soluble hapten.	Water	88-93	FA complementation group B	Homo sapiens	0-3
26030158-2	2015	In addition, experiments showed that this probe can be applied to detect hypochlorite in tap water, serum samples, and living cells with low cytotoxicity.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
25994835-0	2015	Convenient recycling of 3D AgX/graphene aerogels (X = Br, Cl) for efficient photocatalytic degradation of water pollutants.	Water	106-111	UDP-N-acetylglucosamine pyrophosphorylase 1	Homo sapiens	27-30
8389049-5	1993	Another water-soluble analog, choline docosahexaenoate, also stimulated PC-PLC activity.	Water	8-13	heparan sulfate proteoglycan 2	Homo sapiens	75-78
24777283-2	2015	The endfoot membrane domains facing microvessels and pia are enriched with aquaporin-4 water channels (AQP4) and other members of the dystrophin associated protein complex (DAPC).	Water	87-92	aquaporin 4	Mus musculus	75-86
25932979-2	2015	Typically, the instability device is placed at the trunk/upper body (e.g., lying on a Swiss ball); however, a recent product called the Attitube has been developed, which places the location of instability at the hands by users lifting a water-filled tube.	Water	238-243	tubulin epsilon 1	Homo sapiens	140-144
24777283-2	2015	The endfoot membrane domains facing microvessels and pia are enriched with aquaporin-4 water channels (AQP4) and other members of the dystrophin associated protein complex (DAPC).	Water	87-92	aquaporin 4	Mus musculus	103-107
8511529-2	1993	Clinically it consists mainly of postural headache associated with CSF pressure lower than 5 cm H2O.	Water	96-99	colony stimulating factor 2	Homo sapiens	67-70
26035391-5	2015	Treatment groups were administered MTP-131, a water-soluble tetrapeptide that selectively targets mitochondrial cardiolipin and promotes efficient electron transfer, either systemically or in eye drops.	Water	46-51	lysosomal-associated protein transmembrane 4A	Mus musculus	35-38
26411480-10	2015	Tap water, well water and wastewater samples were also analyzed to evaluate the method capability for real sample analysis.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
8487302-4	1993	The present model includes residues 1 to 108, the two Ca2+ of the CD and EF loops, two intermolecular Ca2+, and 103 water molecules per oncomodulin molecule.	Water	116-121	oncomodulin	Rattus norvegicus	136-147
26506001-7	2015	Suspected cholera cases attributable to a suboptimal tap water supply reached 23.2% of total admissions (95% CI 11.4%-33.2%).	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
26506001-8	2015	Although generally reporting less admissions to the CTC, neighbourhoods with a higher consumption of tap water were more affected by water supply interruptions, with a rate ratio of 3.71 (95% CI: 1.91-7.20) and an attributable fraction of cases of 31.4% (95% CI: 17.3%-42.5%).	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
25940464-10	2015	Meanwhile, NMMT and CTS polymers assisted the adsorptive removal of extracellular MC-LR released to water.	Water	100-105	transthyretin	Homo sapiens	20-23
8489003-2	1993	Release of tritiated water into the medium was thereupon detected utilizing its lack of binding to active charcoal, which is an established technique to measure in situ thymidylate synthase activity.	Water	21-26	thymidylate synthetase	Homo sapiens	169-189
25913278-2	2015	NMO is the only demyelinating disease with a clinically useful serum biomarker, aquaporin-4, a water channel protein expressed on astrocytes.	Water	95-100	aquaporin 4	Homo sapiens	80-91
26042532-4	2015	The initial particle size of NP2 and NP3 in water was at a nanoscale whilst NP1 tended to form microscale aggregates.	Water	44-49	neuropilin 2	Homo sapiens	29-32
26042532-4	2015	The initial particle size of NP2 and NP3 in water was at a nanoscale whilst NP1 tended to form microscale aggregates.	Water	44-49	leukemia NUP98 fusion partner 1	Homo sapiens	37-40
24234865-2	1993	accompanied by the loss of a water molecule was investigated by liquid secondary ion mass spectrometry/fast-atom bombardment (LSIMS/FAB).	Water	29-34	FA complementation group B	Homo sapiens	132-135
26334055-3	2015	One of the most common antibacterial agents, oxytetracycline (OTC), was detected at concentrations as low as 1 nM in both buffer solution and tap water, which was 25-fold more sensitive, compared to the previous absorbance-based colorimetric aptasensors.	Water	146-151	nuclear RNA export factor 1	Homo sapiens	142-145
25343537-1	2015	PURPOSE: The objective of this study is to analyze the use of the 6-20 RPE scale for prescribing and self-regulating heated water-based exercise (HEx) and land-based exercise (LEx) in heart transplant recipients.	Water	124-129	ribulose-5-phosphate-3-epimerase	Homo sapiens	71-74
26132581-8	2015	Placental water content, which is regulated by active transport of solutes, was increased by LPD (P = 0.0001).	Water	10-15	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Mus musculus	93-96
8443162-0	1993	CO recombination to human myoglobin mutants in glycerol-water solutions.	Water	56-61	myoglobin	Homo sapiens	26-35
26115524-0	2015	Water Channels Aquaporin 4 and -1 Expression in Subependymoma Depends on the Localization of the Tumors.	Water	0-5	aquaporin 4	Homo sapiens	15-33
26442138-1	2015	The tensile strength of ordinary water such as tap water or seawater is typically well below 1 bar.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	47-50
26271894-0	2015	Hydrogen-rich water attenuates amyloid beta-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.	Water	14-19	sirtuin 1	Homo sapiens	89-94
8462112-4	1993	Similarly, baker"s yeast (Saccharomyces cerevisiae), which has six amino acid residues in histone H3 identical with peptide M of S-Ag, induced EAU when injected into rats.	Water	143-146	S-antigen visual arrestin	Rattus norvegicus	129-133
26261085-3	2015	The cystic fibrosis transmembrane-conductance regulator (CFTR) chloride channel plays an important role in fluid and water transport across the intestinal mucosa.	Water	117-122	cystic fibrosis transmembrane conductance regulator	Mus musculus	4-55
26261085-3	2015	The cystic fibrosis transmembrane-conductance regulator (CFTR) chloride channel plays an important role in fluid and water transport across the intestinal mucosa.	Water	117-122	cystic fibrosis transmembrane conductance regulator	Mus musculus	57-61
25873417-2	2015	As suggested by the calculated transition-state structures for water-promoted imine-enamine isomerization, anti-selective aldol reaction and hemiaminal formation, the rate of this aldol reaction was found experimentally to be even more accelerated by the addition of cis-2-butene-1,4-diol as additive.	Water	63-68	suppressor of cytokine signaling 2	Homo sapiens	267-272
26012957-3	2015	We use magnetic relaxation dispersion (MRD) to directly monitor internal-water dynamics in apo and palmitate-bound rat intestinal fatty acid-binding protein (rIFABP).	Water	73-78	fatty acid binding protein 2	Rattus norvegicus	158-164
26012957-4	2015	Specifically, we record the water (2)H and (17)O MRD profiles of the apo and holo forms of rIFABP in solution or immobilized by covalent cross-links.	Water	28-33	fatty acid binding protein 2	Rattus norvegicus	91-97
25747363-4	2015	Adsorbable organic halide (AOX) formation was significant when applying the UV/chlorine process in water that had not been previously chlorinated, while little additional formation was observed in prechlorinated water.	Water	99-104	acyl-CoA oxidase 1	Homo sapiens	27-30
25747363-7	2015	During simulated secondary disinfection of AOP-treated water, DBP formation potential for THMs, HAAs, HANs, and AOX was observed to increase approximately to the same extent as was observed for pretreatment using the more common AOP of UV combined with hydrogen peroxide (UV/H2O2).	Water	55-60	acyl-CoA oxidase 1	Homo sapiens	112-115
8321420-0	1993	Hypothalamic infusion of activin A increases water consumption and urine volume in the rat.	Water	45-50	inhibin subunit beta A	Rattus norvegicus	25-34
26075870-0	2015	Solvent Properties of Water in Aqueous Solutions of Elastin-Like Polypeptide.	Water	22-27	elastin	Homo sapiens	52-59
8431455-5	1993	Embedment of the lipo-gastrins in phosphatidylcholine bilayers at high lipid/gastrin ratios as mimicry of the cell membrane bound state does not result in onset of ordered structure, but leads to full exposure of the gastrin in essentially randomly coiled form at the water/lipid interface.	Water	268-273	gastrin	Homo sapiens	22-29
26526878-1	2015	Aquaporin-4 water channels play a central role in brain water regulation in neurological disorders.	Water	12-17	aquaporin 4	Homo sapiens	0-11
26526878-1	2015	Aquaporin-4 water channels play a central role in brain water regulation in neurological disorders.	Water	56-61	aquaporin 4	Homo sapiens	0-11
26526878-2	2015	Aquaporin-4 is abundantly expressed at the astroglial endfeet facing the cerebral vasculature and the pial membrane, and both its expression level and subcellular localization significantly influence brain water transport.	Water	206-211	aquaporin 4	Homo sapiens	0-11
26053757-3	2015	Our results demonstrated that the studied extracts contain water soluble compounds able to inhibit MMP-2 and MMP-9 activity and expression.	Water	59-64	matrix metallopeptidase 9	Rattus norvegicus	109-114
26526878-4	2015	Furthermore, aquaporin-4 channels play a beneficial role in brain water clearance in vasogenic edema, but a detrimental role in cytotoxic edema and exacerbate cell swelling.	Water	66-71	aquaporin 4	Homo sapiens	13-24
8386360-1	1993	The structure of human corticotropin releasing factor (hCRF) has been determined by proton nuclear magnetic resonance (1H NMR) in a mixed-solvent system of 66% trifluoroethanol/34% H2O at pH 3.8 and 37 degrees C. Nearly complete resonance assignment was achieved by using standard two-dimensional methods.	Water	181-184	corticotropin releasing hormone	Homo sapiens	55-59
26526878-6	2015	In this review, we propose that the regulatory mechanisms of aquaporin-4 at the transcriptional, translational, and post-translational levels jointly regulate water permeability in the short and long time scale after injury.	Water	159-164	aquaporin 4	Homo sapiens	61-72
26526878-8	2015	We conclude with an emerging picture of the distinct osmotic environments in cytotoxic and vasogenic edema, and propose that the directions of aquaporin-4-mediated water clearance in these two types of edema are distinct.	Water	164-169	aquaporin 4	Homo sapiens	143-154
26526878-9	2015	The difference in water clearance pathways may provide an explanation for the conflicting observations of the roles of aquaporin-4 in edema resolution.	Water	18-23	aquaporin 4	Homo sapiens	119-130
25669904-8	2015	Widespread reactive gliosis, including displacement of the astrocytic water channel, aquaporin 4, was observed.	Water	70-75	aquaporin 4	Mus musculus	85-96
7677994-7	1993	These studies demonstrated: (i) CHIP28 water channel activity is retained despite substitution of individual cysteines with serine; (ii) cysteine 189 is the Hg(2+)-sensitive residue; (iii) the subunits of the CHIP28 complex are individually active water pores; (iv) residue 189 is critical to proper processing of the CHIP28 protein.	Water	248-253	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	209-215
7677994-7	1993	These studies demonstrated: (i) CHIP28 water channel activity is retained despite substitution of individual cysteines with serine; (ii) cysteine 189 is the Hg(2+)-sensitive residue; (iii) the subunits of the CHIP28 complex are individually active water pores; (iv) residue 189 is critical to proper processing of the CHIP28 protein.	Water	248-253	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	209-215
8417869-7	1993	A marked statistically significant reduction in diaphragmatic activity, as assessed by a decrease in Pdi swings, PTPdi, and Edi, was detected at the levels of 10 and 20 cm H2O; a further significant decrease in these values was observed when PEEPe was added.	Water	172-175	peptidyl arginine deiminase 1	Homo sapiens	101-104
25790314-5	2015	Mechanistic studies showed reduced intracranial pressure at 6 h after CCI in AQP4(-/-) mice, compared with AQP4(+/+) control mice (11 vs. 19 mm Hg), with reduced local brain water accumulation as assessed gravimetrically.	Water	174-179	aquaporin 4	Mus musculus	77-81
25790314-8	2015	We conclude that the mildly improved outcome in AQP4(-/-) mice following CCI results from reduced cytotoxic brain water accumulation, though concurrent cytotoxic and vasogenic mechanisms in TBI make the differences small compared to those seen in disorders where cytotoxic edema predominates.	Water	114-119	aquaporin 4	Mus musculus	48-52
26305398-7	2015	Overall we have reported our efforts to improve the specificity, increase the sensitivity, and eliminate the undesired enzymatic activity of DNase I on surface-adsorbed probes for miR-10b detection using water-soluble graphene nanodevices.	Water	204-209	microRNA 10b	Homo sapiens	180-187
8280492-4	1993	EuroCetus rIL-2 was found to be completely soluble in water and 5% glucose.	Water	54-59	interleukin 2	Rattus norvegicus	10-15
26126173-2	2015	Enhanced mobility of residual H2O molecules via a localized injection of inert Ar-H2 (4%) is attributed to be the reactive gas species for purification of the deposits.	Water	30-33	ADP-ribosylhydrolase like 1	Homo sapiens	79-84
8421053-6	1993	Expression of in vitro transcribed mRNA encoding CHIP28k in Xenopus oocytes increased oocyte osmotic water permeability (Pf) from (4 +/- 1) x 10(-4) to (33 +/- 4) x 10(-4) cm/s at 10 degrees C; the increase in oocyte Pf was weakly temperature dependent and inhibited by HgCl2.	Water	101-106	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	49-55
8399608-4	1993	The third pathway of the three-pore model accounts for only about 2% of the total LpS and is permeable to water but impermeable to solutes, a so-called "water-only" (transcellular?)	Water	106-111	interferon regulatory factor 6	Homo sapiens	82-85
25640045-4	2015	In order to comprehensively understand how the hydratases are able to catalyse the water addition to carbon-carbon double bonds, this review will highlight the mechanistic and stereochemical studies of the enzymatic water addition to carbon-carbon double bonds, focusing on the syn/anti-addition and stereochemistry of the reaction.	Water	83-88	synemin	Homo sapiens	278-281
25640045-4	2015	In order to comprehensively understand how the hydratases are able to catalyse the water addition to carbon-carbon double bonds, this review will highlight the mechanistic and stereochemical studies of the enzymatic water addition to carbon-carbon double bonds, focusing on the syn/anti-addition and stereochemistry of the reaction.	Water	216-221	synemin	Homo sapiens	278-281
25187042-5	2015	Performance in the Morris water maze revealed impairments in long-term reference memory in 6-month-old Abeta administered animals, which was not seen in 3-month-old animals.	Water	26-31	amyloid beta precursor protein	Rattus norvegicus	103-108
8399608-4	1993	The third pathway of the three-pore model accounts for only about 2% of the total LpS and is permeable to water but impermeable to solutes, a so-called "water-only" (transcellular?)	Water	153-158	interferon regulatory factor 6	Homo sapiens	82-85
11539430-4	1993	Such environments can serve as terrestrial models for the last stages of life in the history of Mars, when the surface cooled down and atmosphere and water disappeared.	Water	150-155	methionyl-tRNA synthetase 1	Homo sapiens	96-100
8469787-7	1993	The fractional reabsorption of sodium and water by the proximal nephron increased during rIL2 treatment, from 0.707 +/- 0.030 (pretreatment) to 0.793 +/- 0.043.	Water	42-47	interleukin 2	Rattus norvegicus	89-93
26081775-8	2015	This allowed discriminating period 2 (oxic water) as significantly different compared to other periods.	Water	43-48	period circadian regulator 2	Homo sapiens	28-36
1460010-2	1992	The catalytic domain of LPL mediates the esterase function of the enzyme but separate lipid binding sites have been proposed to be involved in the interaction of LPL with emulsified lipid substrates at the water-lipid interface.	Water	206-211	lipoprotein lipase	Homo sapiens	24-27
26077311-10	2015	The available data characterize eukaryotic FGE as a monooxygenase, in which Cys336/Cys341 disulfide bridge formation donates the electrons required to reduce one oxygen atom of O2 to water while the other oxygen atom oxidizes the CxPxR cysteine to FGly.	Water	183-188	sulfatase modifying factor 1	Homo sapiens	43-46
1460010-2	1992	The catalytic domain of LPL mediates the esterase function of the enzyme but separate lipid binding sites have been proposed to be involved in the interaction of LPL with emulsified lipid substrates at the water-lipid interface.	Water	206-211	lipoprotein lipase	Homo sapiens	162-165
25683198-1	2015	It is generally believed that in vertebrates, prolactin (PRL) is predominantly synthesized and released by pituitary lactotrophs and plays important roles in many physiological processes via activation of PRL receptor (PRLR), including water and electrolyte balance, reproduction, growth and development, metabolism, immuno-modulation, and behavior.	Water	236-241	prolactin	Gallus gallus	46-55
1491447-5	1992	The physiologic roles of EGF produced in the kidney are various; it is mitogenic for tubular epithelial cell, inhibits gluconeogenesis and salt and water reabsorption in the tubules, and effects on glomerular hemodynamics.	Water	148-153	epidermal growth factor	Homo sapiens	25-28
25683198-1	2015	It is generally believed that in vertebrates, prolactin (PRL) is predominantly synthesized and released by pituitary lactotrophs and plays important roles in many physiological processes via activation of PRL receptor (PRLR), including water and electrolyte balance, reproduction, growth and development, metabolism, immuno-modulation, and behavior.	Water	236-241	prolactin	Gallus gallus	57-60
26573047-0	2015	Effective Dose Radon 222 of the Tap Water in Children and Adults People; Minab City, Iran.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
26573047-4	2015	Concentration of (222)Rn in tap water of Minab city in two temperatures 5 and 15 oC was measured by radon meter model RTM1668-2.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
1453463-12	1992	A water-co-operated mechanism, where the cis&lt;--&gt;trans isomerization might possibly consist of (1) transition of the prolyl bond and (2) release of N or C-terminal residues of substrate from CyP, is addressed.	Water	2-7	peptidylprolyl isomerase G	Homo sapiens	196-199
26187189-4	2015	In addition, the A/A/C blend films formed efficient hydrogel film with the water holding capacity of 23.6 times of their weight.	Water	75-80	ADP,ATP carrier protein, mitochondrial	Solanum tuberosum	17-22
26187189-6	2015	The test results of fresh potatoes packaging revealed that all the A/A/C ternary blend films prevented forming of condensed water on the packaged film surface, both A/A/C(AgNPs) and A/A/C(GSE) composite films prevented greening of potatoes during storage.	Water	124-129	ADP,ATP carrier protein, mitochondrial	Solanum tuberosum	67-72
25372987-5	2015	Three water molecules (W1, W2 and W3) form a cluster and play an important role in the recognition of the catalytic and RBP-binding residues.	Water	6-11	retinol binding protein 4	Homo sapiens	120-123
25372987-8	2015	The rest four water molecules (W6, W*, W(#) and W( )) form a distorted tetrahedral cluster and impart stability to the catalytic core of hTTR.	Water	14-19	transthyretin	Homo sapiens	137-141
25372987-9	2015	The conserved water mediated recognition dynamics of the different functional sites may provide some rational clues towards the understanding of the activity and mechanism of hTTR.	Water	14-19	transthyretin	Homo sapiens	175-179
1337139-1	1992	Rate constants of 8-oxy-dGMP (8-hydroxy-dGMP) formation upon incubating dGMP in H2O solutions at different temperatures were determined with differential UV-spectroscopy.	Water	80-83	fliF	Drosophila melanogaster	24-28
26716245-0	2015	Preparation and Characterization of Silver Nanoparticles from the Super-Heated Water Degraded Keratin Solutions.	Water	79-84	keratin	Gallus gallus	94-101
26716245-1	2015	This research demonstrates that silver nanoparticles can be prepared from the chicken feathers keratin solution obtained by superheated water treatment.	Water	136-141	keratin	Gallus gallus	95-102
1337139-1	1992	Rate constants of 8-oxy-dGMP (8-hydroxy-dGMP) formation upon incubating dGMP in H2O solutions at different temperatures were determined with differential UV-spectroscopy.	Water	80-83	fliF	Drosophila melanogaster	40-44
26716245-3	2015	In this study, a facile method was described for synthesis of silver nanoparticles by the super-heated water degradation of chicken feathers keratin without using any additional chemicals.	Water	103-108	keratin	Gallus gallus	141-148
1391338-4	1992	The protein was co-eluted with authentic RBP by pure water.	Water	53-58	retinol binding protein 4	Rattus norvegicus	41-44
26070657-9	2015	Results show in the Morris water maze task, rats in the Abeta+100muA and the Abeta+200muA tDCS groups had shorter escape latency and larger number of crossings on the platform.	Water	27-32	amyloid beta precursor protein	Rattus norvegicus	56-61
1530602-0	1992	Conformational study of cyclo(1,5)-Ac-Pen-Arg-Gly-Asp-Cys-NH2 in water by NMR and molecular dynamics.	Water	65-70	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	38-41
26290299-4	2015	According to the 2008 European Food Safety Authority"s Concise Food Consumption Database, tap water consumption was highest in the northern European countries and in Austria.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
26290299-5	2015	While Germany had a particularly low intake of tap water, it led in consumption of fruit and vegetable juices, soft drinks, and especially bottled water.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
1444430-1	1992	Products observed during anaerobic cyanide transformation are consistent with a hydrolytic pathway (HCN + H2O &lt;--&gt; HCONH2 + H2O &lt;--&gt; HCOOH + NH3).	Water	106-109	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	100-103
26000467-6	2015	Pyrabactin-mediated water transport and ZmPIP gene expression were phosphorylation-dependent, suggesting that ABA-PYR1-(PP2C)-protein kinase-AQP signaling pathway may be involved in this process.	Water	20-25	Probable protein phosphatase 2C 10	Zea mays	120-124
26117215-9	2015	Overall, administration of TPPU with the drinking water led to systemic distribution as well as high drug levels and thus makes chronic sEH inhibition studies possible.	Water	50-55	epoxide hydrolase 2	Rattus norvegicus	136-139
1444430-1	1992	Products observed during anaerobic cyanide transformation are consistent with a hydrolytic pathway (HCN + H2O &lt;--&gt; HCONH2 + H2O &lt;--&gt; HCOOH + NH3).	Water	130-133	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	100-103
1279356-2	1992	A component with long T1 and T2 (T1,1 and T2,1) is associated with a large water fraction alpha 1,1 and alpha 2,1 and a component with short T1 and T2 (T1,2 and T2,2) with a small water fraction alpha 1,2 and alpha 2,2.	Water	75-80	adrenoceptor alpha 1D	Homo sapiens	90-99
25877924-5	2015	Fyn KO mice consistently displayed significantly worse DSS-induced disease than WT, correlating with decreased IL-10 and increased IL-17 in splenocytes and the gut; Fyn KO mice failed to thrive after removal of the DSS water.	Water	219-224	Fyn proto-oncogene	Mus musculus	0-3
25913559-4	2015	It was found that in ionic reverse micelles (surfactant Aerosol OT, AOT), orientational motion (fluorescence anisotropy decay) of MPTS was relatively unhindered, consistent with MPTS being located in the water core of the reverse micelle away from the water-surfactant interface.	Water	204-209	molybdenum cofactor synthesis 2	Homo sapiens	130-134
1436498-5	1992	Pretreatment with cimetidine (a histamine H2 receptor antagonist) significantly thwarted the increases in the brain water content and the blood-brain barrier permeability.	Water	116-121	histamine receptor H 2	Rattus norvegicus	32-53
25913559-4	2015	It was found that in ionic reverse micelles (surfactant Aerosol OT, AOT), orientational motion (fluorescence anisotropy decay) of MPTS was relatively unhindered, consistent with MPTS being located in the water core of the reverse micelle away from the water-surfactant interface.	Water	204-209	molybdenum cofactor synthesis 2	Homo sapiens	178-182
25913559-4	2015	It was found that in ionic reverse micelles (surfactant Aerosol OT, AOT), orientational motion (fluorescence anisotropy decay) of MPTS was relatively unhindered, consistent with MPTS being located in the water core of the reverse micelle away from the water-surfactant interface.	Water	252-257	molybdenum cofactor synthesis 2	Homo sapiens	130-134
25913559-5	2015	In nonionic reverse micelles (surfactant Igepal CO-520, Igepal), however, orientational anisotropy displayed a slow multiexponential decay consistent with wobbling-in-a-cone behavior, indicating MPTS is located at the water-surfactant interface.	Water	218-223	molybdenum cofactor synthesis 2	Homo sapiens	195-199
25732325-0	2015	Serotonin and insulin-like peptides modulate leucokinin-producing neurons that affect feeding and water homeostasis in Drosophila.	Water	98-103	Leucokinin	Drosophila melanogaster	45-55
26320969-3	2015	The probe was used to detect bisulfite in tap water, sugar and dry white wine.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
1510932-2	1992	CHIP28 is an abundant integral membrane protein in RBCs and renal tubules, and Xenopus laevis oocytes injected with CHIP28 RNA exhibit high osmotic water permeability, Pf [Preston et al.	Water	148-153	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	0-6
26075319-2	2015	HyA contains 1.29 to 1.95 molecules of water per DB7 zwitterion (DB7z).	Water	39-44	lysine demethylase 5D	Homo sapiens	0-3
26075319-3	2015	Removal of the essential water stabilizing HyA causes it to collapse to an amorphous phase, frequently concomitantly nucleating the stable anhydrate Forms I and II .	Water	25-30	lysine demethylase 5D	Homo sapiens	43-46
32262851-2	2015	Herein, we developed one kind of water-soluble hyaluronic acid-hybridized polyaniline nanoparticles (HA-PANI NPs) as a nanoplatform for photothermal therapy (PTT) with targeted specificity of a CD44-mediated cancer cell.	Water	33-38	CD44 molecule (Indian blood group)	Homo sapiens	194-198
25728706-7	2015	Protein levels of the well-known Nrf2 target gene NAD(P)H: quinone oxidoreductase 1 (Nqo1) were increased in water-fed PPARbeta/delta-null mice, suggesting that PPARbeta/delta deficiency increases Nrf2 activity; and this increase was exacerbated in fructose-fed PPARbeta/delta-deficient mice.	Water	109-114	NAD(P)H dehydrogenase, quinone 1	Mus musculus	50-83
25728706-7	2015	Protein levels of the well-known Nrf2 target gene NAD(P)H: quinone oxidoreductase 1 (Nqo1) were increased in water-fed PPARbeta/delta-null mice, suggesting that PPARbeta/delta deficiency increases Nrf2 activity; and this increase was exacerbated in fructose-fed PPARbeta/delta-deficient mice.	Water	109-114	NAD(P)H dehydrogenase, quinone 1	Mus musculus	85-89
1510932-2	1992	CHIP28 is an abundant integral membrane protein in RBCs and renal tubules, and Xenopus laevis oocytes injected with CHIP28 RNA exhibit high osmotic water permeability, Pf [Preston et al.	Water	148-153	aquaporin 1 (Colton blood group) S homeolog	Xenopus laevis	116-122
25917596-0	2015	Effects of solvent concentration and composition on protein dynamics: 13C MAS NMR studies of elastin in glycerol-water mixtures.	Water	113-118	elastin	Homo sapiens	93-100
25917596-3	2015	Immersing elastin in various glycerol-water mixtures, we observe at room temperature that the protein mobility is higher for lower glycerol fractions in the solvent and, thus, lower solvent viscosity.	Water	38-43	elastin	Homo sapiens	10-17
1637948-3	1992	Analysis of the water-soluble metabolites of PAF-induced PC hydrolysis in secretory endometrium demonstrated that the stimulated generation of [3H]choline ([3H]Cho) precedes that of [3H]choline phosphate ([3H]ChoP) and [3H]glycerophosphocholine ([3H]GPC).	Water	16-21	PCNA clamp associated factor	Homo sapiens	45-48
25917596-4	2015	When decreasing the temperature, the elastin spectra approach the line shape for the rigid protein at 245 K for all studied samples, indicating that the protein ceases to be mobile on the experimental time scale of ~10(-5) s. Our findings yield evidence for a strong coupling between elastin fluctuations and solvent dynamics and, hence, such interaction is not restricted to the case of protein-water mixtures.	Water	396-401	elastin	Homo sapiens	37-44
25874436-1	2015	Activity concentration of (238)U, (234)U, (226)Ra, (228)Ra, (210)Pb and (210)Po in tap water from selected springs and private wells in the area of the former uranium mine at Zirovski Vrh were determined.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
25735759-6	2015	In the case of slight initial adhesive defects, water storage caused a statistically verifiable increase in adhesive defects at the enamel interface with EF (before/after storage: 4%/8%; p=0.023) and at dentin with PLP (before/after storage: 11%/52%; p=0.008).	Water	48-53	proteolipid protein 1	Homo sapiens	215-218
1629107-1	1992	Regional pulmonary blood flow (rPBF) can be measured with an intravenous infusion of 15O-labeled water and positron emission tomography (PET).	Water	97-102	PTTG1 interacting protein	Rattus norvegicus	31-35
25430011-5	2015	Furthermore, in tap water from Osijek, levels of arsenic exceeded the WHO guidelines and EPA regulations.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
26592023-4	2015	Therefore, some measures are necessary to avoid precipitation, including: (1) raw water pretreatment to reduce the concentrations of Ca2 and Mg2.	Water	82-87	carbonic anhydrase 2	Homo sapiens	133-136
23802652-0	2015	Cleansing of wounds by tap water?	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
26060363-7	2015	Dehydration, history of malaria and drinking untreated well water from are likely contribute to the development of CKD of unknown etiology among the inhabitants of NCP, Sri Lanka.	Water	60-65	sorcin	Homo sapiens	169-172
1386466-0	1992	Intracerebroventricular administration of a specific IL-1 receptor antagonist blocks food and water intake suppression induced by interleukin-1 beta.	Water	94-99	interleukin 1 receptor antagonist	Homo sapiens	53-77
25858030-11	2015	Pharmacological blockade of the AT1 receptor with losartan prior to RNS abolished both the functional and the molecular responses, suggesting that intrarenal Ang II acting via the AT1 receptor is a major factor for NHE3-mediated sodium and water reabsorption induced by RNS.	Water	240-245	solute carrier family 9 member A3	Homo sapiens	215-219
1633849-2	1992	Under optimized conditions, oocytes injected with the STP1 mRNA accumulated 3-O-[methyl-14C]glucose at rates of more than a 1000-fold greater than water-injected control oocytes.	Water	147-152	sulfotransferase family 1A member 1 S homeolog	Xenopus laevis	54-58
25863066-6	2015	In addition, G24-label spectra provide evidence for a partially disordered alpha-helix backbone that participates in hydrogen bonding with the surrounding water.	Water	155-160	lactamase beta	Homo sapiens	13-16
26311834-3	2015	A tendency toward an osmotically induced, V1aR-mediated reduction in AQP4-dependent water permeability was observed, although osmotic challenges failed to mimic vasopressin-dependent V1aR-mediated internalization of AQP4.	Water	84-89	aquaporin 4 L homeolog	Xenopus laevis	69-73
25978950-13	2015	CONCLUSIONS: Fructus Ligustri Lucidi water extract promoted cell proliferation and differentiation, mRNA and protein expression of OPG and RANKL on MC3T3-E1 cells.	Water	37-42	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	131-134
1318095-9	1992	These effects depend on actin filament immobilization, because the ABP concentration that causes initial impairment of water flow by actin filaments corresponds to the gel point measured viscometrically and because gelsolin, which noncovalently severs actin filaments, solates actin gels and restores water flow in a solution of actin cross-linked by ABP.	Water	301-306	gelsolin	Homo sapiens	215-223
26183829-4	2015	By combining phylogenetic and functional studies, here we show that a more efficient form of glycerol transporter related to the water-selective channel AQP4 specifically evolved and multiplied in the insect lineage, resulting in the replacement of the ancestral branch of aquaglyceroporins in holometabolan insects.	Water	129-134	aquaporin 4	Homo sapiens	153-157
26183829-5	2015	To recapitulate this evolutionary process, we generate specific mutants in distantly related insect aquaporins and human AQP4 and show that a single mutation in the selectivity filter converted a water-selective channel into a glycerol transporter at the root of the crown clade of hexapod insects.	Water	196-201	aquaporin 4	Homo sapiens	121-125
25716996-5	2015	Tregs isolated from eyes of mice with EAU efficiently suppressed IRBP-specific responses of Teffs from the same eyes.	Water	38-41	retinol binding protein 3, interstitial	Mus musculus	65-69
1315574-1	1992	Hexokinase is a phosphotransferase that catalyzes phosphoryl transfer from ATP to glucose much more rapidly than the transfer from ATP to water (i.e., hydrolysis).	Water	138-143	hexokinase	Saccharomyces cerevisiae S288C	0-10
25034457-6	2015	We found negative correlations between AgRP levels and total body fat (r =-0.34 and -0.48 in the whole study group and clozapine group, respectively) and positive correlations with lean body mass (r =0.38 and 0.49 in the whole study group and clozapine group, respectively), body water (r =0.34 and 0.49 in the whole study group and clozapine group, respectively) and basal metabolic rate (r =0.42 both in the clozapine and control groups).	Water	280-285	agouti related neuropeptide	Homo sapiens	39-43
25827057-4	2015	The sEH inhibitor 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU) was administered in drinking water.	Water	114-119	epoxide hydrolase 2, cytoplasmic	Mus musculus	4-7
1567910-9	1992	Our results show that the first interaction step between native or modified enzyme and micellar lipid/water interfaces probably consists of a low-affinity Langmuir-type adsorption characterized by signals arising from the perturbation of the single Trp-3 residue.	Water	102-107	tRNA-Pro (anticodon TGG) 3-1	Homo sapiens	249-254
25928251-8	2015	A calculation of the pKa and pKa2 in water of a set of monosubstituted 8-phenylsulfanyl quipazine derivatives was performed using B3LYP/6-31G(d) and the SMD continuum solvation model.	Water	37-42	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	132-135
25698467-5	2015	Good yields (up to 91%) and diastereoselectivities (syn/anti 3 : 1) were observed in the reactions catalyzed by 1 in water.	Water	117-122	synemin	Homo sapiens	52-55
25714488-9	2015	Both samples exhibit excellent intrinsic UV-light activities for pure water splitting without the assistance of any cocatalyst (47 and 118 mumol/h/g for H2 evolution and 22 and 58 mumol/h/g for O2 evolution, respectively), while there is no detectable activity for P25 (nanoparticles of TiO2 with a specific surface area of 69 m(2)/g) under the same conditions.	Water	70-75	transmembrane p24 trafficking protein 9	Homo sapiens	265-268
1526167-4	1992	We have found that EAU could be efficiently induced in rats with low doses of S-Ag (10 micrograms) in very small quantity of HA (10 microliters).	Water	19-22	S-antigen visual arrestin	Rattus norvegicus	78-82
25609088-4	2015	Expression of AQP1 with CAII in Xenopus oocytes or mammalian cells increased water flux relative to AQP1 expression alone.	Water	77-82	carbonic anhydrase 2 S homeolog	Xenopus laevis	24-28
25663339-5	2015	Dissolved oxygen (DO) in the water reduced the 2,4-DNT degradation and the formation of 2,4-DAT.	Water	29-34	solute carrier family 6 member 3	Homo sapiens	92-95
25876999-0	2015	Associations between the polymorphisms of GSTT1, GSTM1 and methylation of arsenic in the residents exposed to low-level arsenic in drinking water in China.	Water	140-145	glutathione S-transferase theta 1	Homo sapiens	42-47
1377630-7	1992	substance P (measured as peak increases in lung resistance in cm H2O/ml per s) at 6 h following antigen was noted in the presence of IL-1ra (30 mg/kg i.p.).	Water	65-68	interleukin 1 receptor antagonist	Homo sapiens	133-139
25957560-2	2015	Aquaporin-4 (AQP4) is a water channel expressed in astrocyte end-feet, which plays an important role in brain edema.	Water	24-29	aquaporin 4	Mus musculus	0-11
25957560-2	2015	Aquaporin-4 (AQP4) is a water channel expressed in astrocyte end-feet, which plays an important role in brain edema.	Water	24-29	aquaporin 4	Mus musculus	13-17
25957560-5	2015	Our results indicate that AQP4 deletion reduced cell death, water content, astrocyte swelling and lesion volume during the acute stage of micro TBI.	Water	60-65	aquaporin 4	Mus musculus	26-30
25888997-13	2015	CONCLUSION: The results of the present study demonstrated that a GLP-1 analog and a DPP4 inhibitor may have beneficial effects on renal sodium and water handling.	Water	147-152	glucagon	Rattus norvegicus	65-70
25343972-2	2015	The AnFB-MBR produced consistent high-quality product water when fed by a synthetic groundwater with NO3 (-)-N ranging 25-80 mg/L and operated at hydraulic retention times of 0.5-5.0 h. A nitrate removal rate of up to 4.0 g NO3 (-)-N/Lreactord was attained by the bioreactor, which exceeded any reported removal capacity.	Water	54-59	translocator protein	Homo sapiens	9-12
25585012-5	2015	Axonal growth in AQP1-deficient DRG cultures was rescued by transfection with AQP1 or a different water-transporting AQP (AQP4), but not by a non-water-transporting AQP1 mutant.	Water	98-103	aquaporin 4	Mus musculus	17-20
25585012-5	2015	Axonal growth in AQP1-deficient DRG cultures was rescued by transfection with AQP1 or a different water-transporting AQP (AQP4), but not by a non-water-transporting AQP1 mutant.	Water	98-103	aquaporin 4	Mus musculus	122-126
25804520-1	2015	Cu/ZnSOD (copper/zinc superoxide dismutase) primarily scavenges cytosolic reactive oxygen species (ROS) by converting ROS to hydrogen peroxide, which is then converted to water by the catalytic action of catalase, thus playing a pivotal role in the first line of defense mechanism against oxidative stress.	Water	171-176	superoxide dismutase [Cu-Zn]	Lates calcarifer	0-42
1547268-1	1992	Studies were conducted to investigate the mechanism by which acidic phospholipid-containing vesicles stimulate purified placental glucosylceramidase activity towards the water-soluble substrate 4-methylumbelliferyl-beta-D-glucopyranoside (MUGlc).	Water	170-175	glucosylceramidase beta	Homo sapiens	130-148
25879561-0	2015	Selective lesion of GABA-ergic neurons in the medial septum by GAT1-saporin impairs spatial learning in a water-maze.	Water	106-111	solute carrier family 6 member 12	Rattus norvegicus	63-67
1522767-0	1992	The inhibitory effect of water on the Co2+ and Cu2+ catalyzed decomposition of methyl linoleate hydroperoxides.	Water	25-30	complement C2	Homo sapiens	38-41
25555117-4	2015	Tap water was infused via a metal trocar for approximately 60 minutes.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
25139477-3	2015	Environmental recirculation can then occur when PFAAs from the environment enter the wastewater stream in, e.g., tap water.	Water	90-95	nuclear RNA export factor 1	Homo sapiens	113-116
25139477-7	2015	With regard to environmental recirculation, tap water was an important source of PFAAs to the Bromma WWTP influent, contributing &gt;40% for each quantified sulfonic acid and up to 30% for the carboxylic acids.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
1522767-1	1992	The inhibitory effect of water on the decomposition of methyl linoleate hydroperoxides (MLHP) catalyzed by Co2+ and Cu2+ was studied in a model system using proton nuclear magnetic resonance (NMR) spectroscopy.	Water	25-30	complement C2	Homo sapiens	107-110
25139477-9	2015	Our results show that in order to estimate current primary emissions from the technosphere, it may be necessary to correct the PFAA emission rates in WWTP effluents for PFAAs present in tap water, especially in the case of elevated levels in tap water.	Water	190-195	nuclear RNA export factor 1	Homo sapiens	186-189
25645872-6	2015	Above a threshold light intensity, photosynthetic electron transport rates (water   CO2) decrease in sta6 due to attenuated rates of NADPH re-oxidation, without affecting photosystems I or II (no change in isolated photosynthetic electron transport).	Water	76-81	uncharacterized protein	Chlamydomonas reinhardtii	101-105
1522767-10	1992	When Co2+ was added to the model system, K decreased as the concentration of water increased from 0% to 1.5%.	Water	77-82	complement C2	Homo sapiens	5-8
1520951-4	1992	We observed that rats bearing PROb tumors only develop an antibody response against a water-soluble protein of 105 kDa (p105) which is expressed by both tumor clones.	Water	86-91	nucleoporin 107	Rattus norvegicus	120-124
25802744-4	2015	Sputum and spa pool water cultured M ycobacterium phocaicum but not MAC.	Water	20-25	surfactant protein A2	Homo sapiens	11-14
25802744-7	2015	phocaicum in spa pool water.	Water	22-27	surfactant protein A2	Homo sapiens	13-16
25942504-2	2015	The humid effect at room temperature is due to the movement of H(+) or H3O(+) inside of the condensed water layer on the surface of La0.875Ca0.125FeO3.	Water	102-107	H3 clustered histone 15	Homo sapiens	71-74
1483407-1	1992	The space in the unit cell of a metmyoglobin crystal not occupied by myoglobin atoms was filled with water using Monte Carlo calculations.	Water	101-106	myoglobin	Homo sapiens	35-44
25902526-1	2015	Human carbonic anhydrase II (HCA II) uses a Zn-bound OH(-)/H2O mechanism to catalyze the reversible hydration of CO2.	Water	59-62	carbonic anhydrase 2	Homo sapiens	6-27
25531406-2	2015	This study investigated temporal variations in the levels of regulated and non-regulated disinfection byproducts (DBPs) in cold and hot tap water in a home on a medium-sized municipal water system.	Water	140-145	nuclear RNA export factor 1	Homo sapiens	136-139
25531406-13	2015	The ratio of unknown total organic halide (UTOX) to TOX was substantially lower in the hot tap water as the THM to TOX ratio became correspondingly larger.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
1532947-9	1992	The osmotic stress of acclimation to 1.5% salt water increased renal but not adrenal ANF binding.	Water	47-52	natriuretic peptide A L homeolog	Xenopus laevis	85-88
25755662-8	2015	The results indicate that the differences in interaction with structural water molecules correlate very well with the observed enzymatic parameters, validate the proposed pentahedric coordination of the catalytic zinc ion in a plant SDH, and provide an explanation for why AtSDH shows a preference for polyols with a chirality of C2 (S) and C4 (R).	Water	73-78	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	233-236
25755662-8	2015	The results indicate that the differences in interaction with structural water molecules correlate very well with the observed enzymatic parameters, validate the proposed pentahedric coordination of the catalytic zinc ion in a plant SDH, and provide an explanation for why AtSDH shows a preference for polyols with a chirality of C2 (S) and C4 (R).	Water	73-78	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	273-278
25575748-8	2015	Although greater salinity decreased Cd and Zn uptake, the metal content in the water correlated with the MT mRNA levels in most of the organs, except for the intestines.	Water	79-84	metallothionein	Oreochromis niloticus	105-107
1932015-5	1991	The data show that the guanine amino group of the nucleotide interacts differently with both EF-Tu and p21 than it does with water, showing a change in hydrogen-bonding properties upon binding.	Water	125-130	H3 histone pseudogene 16	Homo sapiens	103-106
25545558-1	2015	The aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular and subpial membrane domains of astrocytes where it is concentrated.	Water	23-28	aquaporin 4	Homo sapiens	4-15
1930149-4	1991	I further examined the reaction kinetics of BAL with water-soluble short-chain esters of p-nitrophenol.	Water	53-58	carboxyl ester lipase	Homo sapiens	44-47
25545558-1	2015	The aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular and subpial membrane domains of astrocytes where it is concentrated.	Water	23-28	aquaporin 4	Homo sapiens	17-21
1653702-1	1991	An internal water molecule (designated WAT166) is found in iso-1-cytochrome c which is part of a redox-state-dependent hydrogen bond network.	Water	12-17	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	59-64
25540202-0	2015	gamma-Aminobutyric A receptor (GABA(A)R) regulates aquaporin 4 expression in the subependymal zone: relevance to neural precursors and water exchange.	Water	135-140	aquaporin 4	Homo sapiens	51-62
25540202-4	2015	GABA(A)R signaling promotes AQP4 expression by decreasing serine phosphorylation associated with the water channel.	Water	101-106	aquaporin 4	Homo sapiens	28-32
25540202-7	2015	Thus, the regulation of AQP4 by GABA(A)Rs is involved in controlling activation of neural stem cells and water exchange dynamics in the SEZ.	Water	105-110	aquaporin 4	Homo sapiens	24-28
1653702-3	1991	Using saturation transfer 1H-NMR methods, this study measures changes in the electron transfer reactivity for three variants of yeast iso-1-cytochromes c in which the position of this water molecule is altered.	Water	184-189	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	134-139
2058746-1	1991	We have investigated the rapid changes in plasma prolactin and arginine vasopressin (AVP) associated with water satiation in ruminants.	Water	106-111	prolactin	Ovis aries	49-58
25562069-7	2015	This yields values of 3.5 (+-3.1) x 10(-4) for k(SCI + H2O)/k(SCI + SO2) of anti-CH3CHOO and 1.2 (+-1.1) x 10(13) for k(SCI decomposition)/k(SCI + SO2) of syn-CH3CHOO.	Water	55-58	synemin	Homo sapiens	155-158
25730078-7	2015	The SNP CAPN1 3535 in the CAPN1 gene was significantly associated with tenderness and other meat quality traits, where animals inheriting the AA genotype had smaller shear force values, lower water loss rates, and higher IMF contents.	Water	192-197	calpain 1	Gallus gallus	8-13
25730078-7	2015	The SNP CAPN1 3535 in the CAPN1 gene was significantly associated with tenderness and other meat quality traits, where animals inheriting the AA genotype had smaller shear force values, lower water loss rates, and higher IMF contents.	Water	192-197	calpain 1	Gallus gallus	26-31
1932560-4	1991	CD measurements on these hybrid compounds in aqueous and aqueous organic media confirmed the free conformational space for the antigenic gastrin moiety, which is essentially randomly coiled in aqueous solution but retains its ability to fold into the gastrin-specific ordered structure in aqueous organic media as used to mimic the water-limited environment of peptides while interacting with target cells at receptor level.	Water	332-337	gastrin	Homo sapiens	137-144
1932560-4	1991	CD measurements on these hybrid compounds in aqueous and aqueous organic media confirmed the free conformational space for the antigenic gastrin moiety, which is essentially randomly coiled in aqueous solution but retains its ability to fold into the gastrin-specific ordered structure in aqueous organic media as used to mimic the water-limited environment of peptides while interacting with target cells at receptor level.	Water	332-337	gastrin	Homo sapiens	251-258
24996934-5	2015	Following the discovery of aquaporins, passive conduits of water flow, aquaporin 4 (AQP4) was identified as the predominant astrocyte water channel.	Water	59-64	aquaporin 4	Homo sapiens	84-88
1874911-2	1991	Hydrolysates of elastin are treated with a SEP-PAK silica-gel small column and then separated on a silica-gel normal phase column using n-propanol-water-25% ammonia (9:3:0.06, v/v/v) followed by detection at 275 nm.	Water	147-152	elastin	Bos taurus	16-23
24996934-5	2015	Following the discovery of aquaporins, passive conduits of water flow, aquaporin 4 (AQP4) was identified as the predominant astrocyte water channel.	Water	134-139	aquaporin 4	Homo sapiens	71-82
24996934-5	2015	Following the discovery of aquaporins, passive conduits of water flow, aquaporin 4 (AQP4) was identified as the predominant astrocyte water channel.	Water	134-139	aquaporin 4	Homo sapiens	84-88
25561436-0	2015	TiO2 nanotube array photoelectrocatalyst and Ni-Sb-SnO2 electrocatalyst bifacial electrodes: a new type of bifunctional hybrid platform for water treatment.	Water	140-145	strawberry notch homolog 2	Homo sapiens	51-54
1676328-2	1991	infusion (50 micrograms/h over 3 h) of somatostatin (SOM) on Na and water intake of sheep was determined.	Water	68-73	somatostatin	Ovis aries	39-51
25626447-1	2015	BACKGROUND: Neuromyelitis optica (NMO) is a severe demyelinating disorder of the central nervous system (CNS) associated with the presence of an autoimmune antibody response (AQP4-IgG) against the water channel aquaporin-4 (AQP4).	Water	197-202	aquaporin 4	Homo sapiens	175-179
1676328-3	1991	In Na-deplete sheep, infusion of SOM-(28) but not SOM-(14) decreased (P less than 0.05) Na intake, while both SOM-(28) and SOM-(14) increased water intake.	Water	142-147	somatostatin	Ovis aries	123-130
25428514-8	2015	Therefore, the iodide content of tap water, urine and blood serum is monitored using this sensor and it is found that the sensor can detect a range of iodide in tap water, urine and blood serum.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
25428514-8	2015	Therefore, the iodide content of tap water, urine and blood serum is monitored using this sensor and it is found that the sensor can detect a range of iodide in tap water, urine and blood serum.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	161-164
2017012-4	1991	Physical activity, calculated from average daily metabolic rate (ADMR) and BMR, was expressed as an index: PAI = ADMR/BMR, where ADMR was measured with doubly labeled water and BMR was calculated as indicated above.	Water	167-172	serpin family E member 1	Homo sapiens	107-110
25428514-8	2015	Therefore, the iodide content of tap water, urine and blood serum is monitored using this sensor and it is found that the sensor can detect a range of iodide in tap water, urine and blood serum.	Water	165-170	nuclear RNA export factor 1	Homo sapiens	33-36
25428514-8	2015	Therefore, the iodide content of tap water, urine and blood serum is monitored using this sensor and it is found that the sensor can detect a range of iodide in tap water, urine and blood serum.	Water	165-170	nuclear RNA export factor 1	Homo sapiens	161-164
1723632-2	1991	Pretreatment of LEW rats with the monoclonal antibody, MAbS2.4.C5, which defines an epitope in S-antigen, has been shown to effectively inhibit the subsequent induction of EAU with S-antigen.	Water	172-175	S-antigen visual arrestin	Rattus norvegicus	95-104
25525995-1	2015	A novel polysaccharide, here named DP1, was isolated from the fruiting body of Dictyophora indusiata using a water extraction method.	Water	109-114	transcription factor Dp 1	Mus musculus	35-38
25596925-0	2015	Drinking well water and occupational exposure to Herbicides is associated with chronic kidney disease, in Padavi-Sripura, Sri Lanka.	Water	14-19	sorcin	Homo sapiens	113-116
1723632-2	1991	Pretreatment of LEW rats with the monoclonal antibody, MAbS2.4.C5, which defines an epitope in S-antigen, has been shown to effectively inhibit the subsequent induction of EAU with S-antigen.	Water	172-175	S-antigen visual arrestin	Rattus norvegicus	181-190
1649082-1	1991	Ceruloplasmin (CP) effectively inhibited superoxide and ferritin-dependent peroxidation of phospholipid liposomes, using xanthine oxidase or gamma irradiation of water as sources of superoxide.	Water	162-167	ceruloplasmin	Homo sapiens	0-13
25462239-7	2015	Docking into the hSR active site with three thermodynamically favourable water molecules was able to discern qualitatively between good and weak inhibitors.	Water	73-78	HSR	Homo sapiens	17-20
1649082-1	1991	Ceruloplasmin (CP) effectively inhibited superoxide and ferritin-dependent peroxidation of phospholipid liposomes, using xanthine oxidase or gamma irradiation of water as sources of superoxide.	Water	162-167	ceruloplasmin	Homo sapiens	15-17
26088045-12	2015	In this school, we showed a significant association between the number of water containers delivered each week and absenteeism (IRR = 0.98 95% CI 0.96-1.00).	Water	74-79	insulin receptor related receptor	Homo sapiens	128-131
2125759-7	1990	Intraperitoneal, intragastric and all BSO-drinking water exposures also significantly induced (130-195%) cytosolic glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene.	Water	51-56	hematopoietic prostaglandin D synthase	Rattus norvegicus	115-140
25085943-8	2015	RESULTS: Twenty low-birthweight infants receiving 0.3+-0.04% supplemental oxygen on CPAP of 6 cm H2O were studied at an average of 33 days of age (+-23 days, SD).	Water	97-100	centromere protein J	Homo sapiens	84-88
25767807-2	2015	In breast carcinomas, high levels of aquaporin 5 (AQP5), a membrane protein involved in water transport, have been linked to increased cell proliferation and migration, thus facilitating tumor progression.	Water	88-93	aquaporin 5	Mus musculus	37-48
25767807-2	2015	In breast carcinomas, high levels of aquaporin 5 (AQP5), a membrane protein involved in water transport, have been linked to increased cell proliferation and migration, thus facilitating tumor progression.	Water	88-93	aquaporin 5	Mus musculus	50-54
2125759-8	1990	Significant increases in UDP-glucuronosyltransferase and glutathione S-transferase activities were also observed following 3 days of exposure to BSO in the drinking water at a concentration as low as 5 mM.	Water	165-170	hematopoietic prostaglandin D synthase	Rattus norvegicus	57-82
2078415-3	1990	In the search for a method allowing the copurification of the gp120 with the virion we have applied two-phase extraction based on water-soluble polymers.	Water	130-135	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	62-67
25472798-7	2015	Treatment with the TNFSF10 neutralizing antibody resulted in dramatic improvement of cognitive parameters, as assessed by the Morris water maze test and the novel object recognition test.	Water	133-138	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	19-26
2176256-9	1990	ADH and increased hydraulic conductivity of the collecting tubules possibly contribute to decreased free water clearance.	Water	105-110	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	0-3
25454232-12	2015	Lead concentrations in tap water above 5mug/L were also positively correlated with the GM, 75th and 90th quantiles of BLLs in children drinking tap water.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
25454232-12	2015	Lead concentrations in tap water above 5mug/L were also positively correlated with the GM, 75th and 90th quantiles of BLLs in children drinking tap water.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	144-147
25454232-12	2015	Lead concentrations in tap water above 5mug/L were also positively correlated with the GM, 75th and 90th quantiles of BLLs in children drinking tap water.	Water	148-153	nuclear RNA export factor 1	Homo sapiens	23-26
25454232-12	2015	Lead concentrations in tap water above 5mug/L were also positively correlated with the GM, 75th and 90th quantiles of BLLs in children drinking tap water.	Water	148-153	nuclear RNA export factor 1	Homo sapiens	144-147
25575748-10	2015	The levels of MT mRNA in the livers and kidneys of tilapia might therefore be used as biomarkers of exposure to Cd(2+), Cu(2+) and Zn(2+) in water of various salinities.	Water	141-146	metallothionein	Oreochromis niloticus	14-16
25813634-4	2015	Considering MCHM guidelines for drinking water, the spill represented a serious health threat through the water up taken by the treatment plant located on the Elk river and it also constituted a risk of contamination for the drinking water produced by treatment plants located on the Kanawha river.	Water	41-46	potassium voltage-gated channel subfamily H member 8	Homo sapiens	159-162
2223850-1	1990	The cholesterol esterase-catalyzed hydrolysis of the water-soluble substrate p-nitrophenyl butyrate occurs via an acylenzyme mechanism, and is competitively inhibited by boronic acid transition state analog inhibitors.	Water	53-58	carboxyl ester lipase	Homo sapiens	4-24
25985943-1	2015	The ST2 interaction potential has been used in a large number of simulation studies to explore the possibility of a liquid-liquid phase transition (LLPT) in supercooled water.	Water	169-174	ST2	Homo sapiens	4-7
26236385-0	2015	Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells.	Water	59-64	thioredoxin reductase 1	Homo sapiens	13-36
26236385-5	2015	Here, we show that KRG water extract increases the expression of TrxR1 in human umbilical vein endothelial cells via the p38 and PKC-delta signaling pathways.	Water	23-28	thioredoxin reductase 1	Homo sapiens	65-70
25985943-3	2015	Our results show that in this region there is a substantial free-energy cost for the formation of small ice nuclei, demonstrating that the thermodynamic anomalies associated with the Widom line in ST2 water occur in a well-defined metastable liquid phase.	Water	201-206	ST2	Homo sapiens	197-200
2166599-2	1990	Inelastic neutron scattering spectra of myoglobin hydrated to 0.33 g water (D2O)/g protein have been measured in the low frequency range (1-150 cm-1) at various temperatures between 100 and 350 K. The spectra at low temperatures show a well-resolved maximum in the incoherent dynamic structure factor Sinc(q, omega) at approximately 25 cm-1 and no elastic broadening.	Water	69-74	myoglobin	Homo sapiens	40-49
25756753-1	2015	H3 O(+) and OH(-) , formed by the self-ionization of two coordinating water molecules during the crystal growing of a host molecule [1,3,5-tris(hydroxymethyl)2,4,6-triethylbenzene (1)], could be effectively stabilized by hydrogen-bonding interactions with the preorganized hydroxy groups of three molecules of 1.	Water	70-75	H3 clustered histone 15	Homo sapiens	0-17
26065434-4	2015	NHE3 participates in the uptake of sodium ions and water from the intestinal lumen.	Water	51-56	solute carrier family 9 member A3	Homo sapiens	0-4
2317548-9	1990	Anisotropy values, taken together with intracellular life-times and the calibration between r and eta/tau f for water/glycerol mixtures, gave eta values of 10-13 cP at 23 degrees C. These values assume little fluorophore binding to intracellular components and are therefore upper limits to cytoplasmic viscosity.	Water	112-117	endothelin receptor type A	Canis lupus familiaris	142-145
26856179-3	2015	The population health risk assessment was performed according to public health regulatory methods P 2.1.10.1920-04 in relation to the ionic composition of tap water consumed by children"s population of the city of Kazan.	Water	159-164	nuclear RNA export factor 1	Homo sapiens	155-158
26856179-4	2015	The use of a risk assessment in consumption of tap water by the most susceptible population group with localized residence allows to identify zones in the boundaries of the urban area in which water is needed post-treatment of tap waters flowing to consumers.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
26856179-4	2015	The use of a risk assessment in consumption of tap water by the most susceptible population group with localized residence allows to identify zones in the boundaries of the urban area in which water is needed post-treatment of tap waters flowing to consumers.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	227-230
26856179-4	2015	The use of a risk assessment in consumption of tap water by the most susceptible population group with localized residence allows to identify zones in the boundaries of the urban area in which water is needed post-treatment of tap waters flowing to consumers.	Water	193-198	nuclear RNA export factor 1	Homo sapiens	47-50
25595746-0	2015	The first association of a primary amebic meningoencephalitis death with culturable Naegleria fowleri in tap water from a US treated public drinking water system.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	105-108
25595746-6	2015	His only reported water exposure was tap water; in particular, tap water that was used to supply water to a lawn water slide on which the child had played extensively prior to becoming ill. Water samples were collected from both the home and the water distribution system that supplied the home and tested; N. fowleri was identified in water samples from both the home and the water distribution system.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	37-40
25595746-6	2015	His only reported water exposure was tap water; in particular, tap water that was used to supply water to a lawn water slide on which the child had played extensively prior to becoming ill. Water samples were collected from both the home and the water distribution system that supplied the home and tested; N. fowleri was identified in water samples from both the home and the water distribution system.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	63-66
25595746-6	2015	His only reported water exposure was tap water; in particular, tap water that was used to supply water to a lawn water slide on which the child had played extensively prior to becoming ill. Water samples were collected from both the home and the water distribution system that supplied the home and tested; N. fowleri was identified in water samples from both the home and the water distribution system.	Water	190-195	nuclear RNA export factor 1	Homo sapiens	63-66
25595746-6	2015	His only reported water exposure was tap water; in particular, tap water that was used to supply water to a lawn water slide on which the child had played extensively prior to becoming ill. Water samples were collected from both the home and the water distribution system that supplied the home and tested; N. fowleri was identified in water samples from both the home and the water distribution system.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	63-66
25595746-6	2015	His only reported water exposure was tap water; in particular, tap water that was used to supply water to a lawn water slide on which the child had played extensively prior to becoming ill. Water samples were collected from both the home and the water distribution system that supplied the home and tested; N. fowleri was identified in water samples from both the home and the water distribution system.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	63-66
25595746-6	2015	His only reported water exposure was tap water; in particular, tap water that was used to supply water to a lawn water slide on which the child had played extensively prior to becoming ill. Water samples were collected from both the home and the water distribution system that supplied the home and tested; N. fowleri was identified in water samples from both the home and the water distribution system.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	63-66
26856179-4	2015	The use of a risk assessment in consumption of tap water by the most susceptible population group with localized residence allows to identify zones in the boundaries of the urban area in which water is needed post-treatment of tap waters flowing to consumers.	Water	193-198	nuclear RNA export factor 1	Homo sapiens	227-230
25802761-0	2015	Calcium Alginate-Neusilin US2 Nanocomposite Microbeads for Oral Sustained Drug Delivery of Poor Water Soluble Drug Aceclofenac Sodium.	Water	96-101	usherin	Homo sapiens	26-29
25802761-8	2015	Neusilin US2 is a novel filler used to convert L-ME into solid nanocomposite microbeads to enhance dissolution rate of poor water soluble drugs sustaining the drug release for prolonged period of time.	Water	124-129	usherin	Homo sapiens	9-12
2082835-3	1990	The thioredoxin reductase/thioredoxin system has been shown to reduce superoxide anion radicals through hydrogen peroxide to water.	Water	125-130	peroxiredoxin 5	Homo sapiens	4-25
25542943-6	2015	RESULTS: All 10 sonographically guided PSTJ tap water injections were accurate, distending both the posterior and lateral PSTJ recesses.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
2082835-3	1990	The thioredoxin reductase/thioredoxin system has been shown to reduce superoxide anion radicals through hydrogen peroxide to water.	Water	125-130	thioredoxin	Homo sapiens	4-15
25706509-3	2015	The dynamics of water in the interdomain region between an E3 ubiquitin ligase (MDM2) and three different peptides derived from the tumor suppressor protein p53 are studied using molecular dynamics.	Water	16-21	MDM2 proto-oncogene	Homo sapiens	80-84
2282064-1	1990	Treatment of cancer patients with disseminating malignancy using human recombinant interleukin-2 (rIL-2) is usually complicated by some adverse effects such as hypotension, an increase in vascular permeability and water retention due to the so-called "capillary leak syndrome".	Water	214-219	interleukin 2	Rattus norvegicus	98-103
25706509-6	2015	Additionally, the hydrophobic staple shields a network of water molecules, kinetically stabilizing a water chain hydrogen-bonded between the peptide and MDM2.	Water	58-63	MDM2 proto-oncogene	Homo sapiens	153-157
25706509-6	2015	Additionally, the hydrophobic staple shields a network of water molecules, kinetically stabilizing a water chain hydrogen-bonded between the peptide and MDM2.	Water	101-106	MDM2 proto-oncogene	Homo sapiens	153-157
26260606-2	2015	The quality of GPCR structures available for SBDD projects fall on a spectrum ranging from high resolution crystal structures (&lt;2 A), where all water molecules in the binding pocket are resolved, to lower resolution (&gt;3 A) where some protein residues are not resolved, and finally to homology models that are built using distantly related templates.	Water	147-152	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	15-19
2165464-6	1990	Finally, [Pro7] NKB, which completely discriminates NK-2 and NK-3 binding sites, is a water-soluble NK-3 selective agonist.	Water	86-91	tachykinin precursor 3	Homo sapiens	16-19
25734186-4	2015	Activities of antioxidant enzymes, superoxide dismutase (SOD), and catalase (CAT) increased significantly over water control.	Water	111-116	catalase	Vigna radiata	67-75
25734186-4	2015	Activities of antioxidant enzymes, superoxide dismutase (SOD), and catalase (CAT) increased significantly over water control.	Water	111-116	catalase	Vigna radiata	77-80
25791354-4	2015	The MGL composites showed good water-dispersity, strong magnetic response, and high sorption capacities and removal efficiencies for both Pb(II) and 2,4-D pollutants.	Water	31-36	C-type lectin domain containing 10A	Homo sapiens	4-7
25274064-2	2015	Mutations in the CFTR gene cause cystic fibrosis in which salt, water, and protein transports are defective in various tissues.	Water	64-69	cystic fibrosis transmembrane conductance regulator	Mus musculus	17-21
2295792-4	1990	rIL-2 has been chemically modified with a water soluble polymer, monomethoxy polyethylene glycol (PEG).	Water	42-47	interleukin 2	Rattus norvegicus	0-5
25523640-10	2015	The mRNA and protein expression levels of PAR-1, MMP-9 and AQP4 started to increase at 24 h and reached a maximal level at 48 h. Focal mild hypothermia tended to significantly reduce brain water content, BBB disruption and PAR-1, MMP-9 and AQP expression at 24 and 48 h. The present data suggest that focal mild hypothermia is an effective treatment for edema formation through moderation of the mRNA and protein expression of PAR-1, MMP-9 and AQP4.	Water	189-194	coagulation factor II (thrombin) receptor	Rattus norvegicus	42-47
25523640-10	2015	The mRNA and protein expression levels of PAR-1, MMP-9 and AQP4 started to increase at 24 h and reached a maximal level at 48 h. Focal mild hypothermia tended to significantly reduce brain water content, BBB disruption and PAR-1, MMP-9 and AQP expression at 24 and 48 h. The present data suggest that focal mild hypothermia is an effective treatment for edema formation through moderation of the mRNA and protein expression of PAR-1, MMP-9 and AQP4.	Water	189-194	matrix metallopeptidase 9	Rattus norvegicus	49-54
32262215-3	2014	Cationic poly-l-lysine-graft-imidazole (PLI) with a reactive silane moiety was stably immobilized onto the surface of the assembled manganese ferrite nanoparticles (MFs) through an emulsion process, ensuring high water solubility, enhanced MR contrast effect, and endosome-disrupting functionality.	Water	213-218	serpin family F member 2	Homo sapiens	40-43
25489068-0	2014	Site-specific vibrational spectral signatures of water molecules in the magic H3O+ (H2O)20 and Cs+ (H2O)20 clusters.	Water	49-54	H3 clustered histone 15	Homo sapiens	78-81
25489068-0	2014	Site-specific vibrational spectral signatures of water molecules in the magic H3O+ (H2O)20 and Cs+ (H2O)20 clusters.	Water	84-87	H3 clustered histone 15	Homo sapiens	78-81
25489068-3	2014	Here we exploit the slow cooling afforded by cryogenic ion trapping, along with isotopic substitution, to quench water clusters attached to the H3O(+) and Cs(+) ions into structures that yield well-resolved vibrational bands over the entire 215- to 3,800-cm(-1) range.	Water	113-118	H3 clustered histone 15	Homo sapiens	144-150
25732607-4	2015	Bright orange single crystals of the solvatomorph [Fe(II)(hpdpt)2(SCN)2] MeOH H2O (2solv) were also structurally and magnetically characterized and, in contrast to 2, found to remain HS down to 4 K, providing further evidence of the huge impact of crystal packing on SCO.	Water	78-81	growth factor independent 1 transcriptional repressor	Homo sapiens	66-71
2314191-10	1990	The large increase in circulating AVP may represent a desirable water conservation response in anticipation of fluid losses induced by vomiting.	Water	64-69	arginine vasopressin	Canis lupus familiaris	34-37
25263880-1	2014	MDG-1, a water-soluble polysaccharide extracted from Ophiopogon japonicus, has potent hypoglycemic and weight control effects.	Water	9-14	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	0-5
33811845-2	2021	Aquaporin-3 (AQP3) is a water, glycerol and H2O2 transporting channel expressed in colonic epithelia.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
25428372-8	2014	The conformations of these binding pockets include direct binding through desolvated ion bridges in the GpC steps in B-DNA and A-RNA; direct binding to backbone oxygens; binding of Mg[(H2O)6](2+) to distant phosphates, resulting in acute bending of A-RNA; tight "ion traps" in Z-RNA between C-O2 and the C-O2" atoms in GpC steps; and others.	Water	185-188	glycophorin C (Gerbich blood group)	Homo sapiens	104-107
25428372-8	2014	The conformations of these binding pockets include direct binding through desolvated ion bridges in the GpC steps in B-DNA and A-RNA; direct binding to backbone oxygens; binding of Mg[(H2O)6](2+) to distant phosphates, resulting in acute bending of A-RNA; tight "ion traps" in Z-RNA between C-O2 and the C-O2" atoms in GpC steps; and others.	Water	185-188	glycophorin C (Gerbich blood group)	Homo sapiens	319-322
25617595-0	2015	Opposite effects of oxytocin on water intake induced by hypertonic NaCl or polyethylene glycol administration.	Water	32-37	oxytocin/neurophysin I prepropeptide	Homo sapiens	20-28
25617595-1	2015	Oxytocin (OT), a neurohormone, has been related to natriuretic and diuretic effects and also to water intake and sodium appetite.	Water	96-101	oxytocin/neurophysin I prepropeptide	Homo sapiens	0-8
25617595-1	2015	Oxytocin (OT), a neurohormone, has been related to natriuretic and diuretic effects and also to water intake and sodium appetite.	Water	96-101	oxytocin/neurophysin I prepropeptide	Homo sapiens	10-12
25617595-2	2015	The objective of the present study was to determine the effect of subcutaneous OT administration on water intake and urine-related measures induced by the administration of hypertonic NaCl (experiment 1) or polyethylene glycol (PEG) (experiment 2).	Water	100-105	oxytocin/neurophysin I prepropeptide	Homo sapiens	79-81
25617595-3	2015	Experiment 1 showed that OT administration increases the urine volume, urinary sodium concentration, and natriuresis and reduces the water intake, water and sodium balances, and estimated plasma sodium concentration induced by hypertonic NaCl administration.	Water	133-138	oxytocin/neurophysin I prepropeptide	Homo sapiens	25-27
25617595-3	2015	Experiment 1 showed that OT administration increases the urine volume, urinary sodium concentration, and natriuresis and reduces the water intake, water and sodium balances, and estimated plasma sodium concentration induced by hypertonic NaCl administration.	Water	147-152	oxytocin/neurophysin I prepropeptide	Homo sapiens	25-27
25259680-2	2014	Tap water quality was investigated at a six month old plumbing system and chemical and odor quality impacts of six PEX pipe brands were examined.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
25617595-4	2015	Conversely, experiment 2 showed that OT administration increases the water intake and the antidiuretic response induced by PEG administration.	Water	69-74	oxytocin/neurophysin I prepropeptide	Homo sapiens	37-39
33811845-2	2021	Aquaporin-3 (AQP3) is a water, glycerol and H2O2 transporting channel expressed in colonic epithelia.	Water	24-29	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
25617595-5	2015	These results show that the opposite effects of OT on the water intake induced by hypertonic NaCl or PEG administration are accompanied by differential regulatory effects, enhancing a natriuretic response in the first experiment and generating an antidiuretic reaction in the second experiment.	Water	58-63	oxytocin/neurophysin I prepropeptide	Homo sapiens	48-50
25459222-1	2014	The hybrid membrane process (HMP) coupling powdered activated carbon (PAC) and low-pressure membrane filtration is emerging as a promising new option to remove dissolved contaminants from drinking water.	Water	197-202	inner membrane mitochondrial protein	Homo sapiens	29-32
33767380-6	2022	We showed that APP/PS1 mice displayed significant cognitive deficit in Morris water maze test, myocardial ultrastructural, geometric (cardiac atrophy, interstitial fibrosis) and functional (reduced fractional shortening and cardiomyocyte contraction) anomalies along with oxidative stress, apoptosis, and inflammation in myocardium.	Water	78-83	presenilin 1	Mus musculus	19-22
25494788-9	2014	We combine the SFG data with molecular dynamics simulations to obtain a molecular-level picture of the interaction of GALA with the air-water interface.	Water	136-141	galactosidase alpha	Homo sapiens	118-122
25213563-3	2014	RS-N shows selective color change from colorless to pink in the presence of Hg(2+) in methanol/water solvent and the UV-Vis study shows peak at 560 nm.	Water	95-100	CAP-Gly domain containing linker protein 1	Homo sapiens	0-4
25635472-5	2015	The major reasons for this were the small dimensions of the CNF and their high aspect ratio, which is important for gel-formation and the complex viscoelastic modulus of the particle-filled air-water interface.	Water	194-199	NPHS1 adhesion molecule, nephrin	Homo sapiens	60-63
33762677-0	2021	Evidence for influx of Atlantic water masses to the Labrador Sea during the Last Glacial Maximum.	Water	32-37	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	61-64
25665073-6	2015	Wet water-soaked films of CNF/chitosan 80/20 w/w show excellent mechanical properties, with an ultimate wet strength of 100 MPa (with corresponding maximum strain of 28%) and a tensile modulus of 4 and 14 GPa at low (0.5%) and large (16%) strains, respectively.	Water	4-9	NPHS1 adhesion molecule, nephrin	Homo sapiens	26-29
25823213-1	2014	London tap water experiment.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
33762677-4	2021	Although surface-water conditions were cold and sea-ice loaded, the lower strata of the (proto) West Greenland Current carried a significant Atlantic (Irminger Sea-derived) Water signal, while at the deeper site the sea floor was swept by a water mass comparable with present Northeast Atlantic Deep Water.	Water	173-178	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	160-163
33762677-6	2021	Immediately after the LGM, deglaciation was characterized by a prominent deep-water ventilation event and potentially Labrador Sea Water formation, presumably related to brine formation and/or hyperpycnal meltwater flows.	Water	131-136	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	127-130
24999750-2	2014	Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of brain cells and the development of brain edema after TBI.	Water	38-43	aquaporin 4	Homo sapiens	0-11
24999750-2	2014	Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of brain cells and the development of brain edema after TBI.	Water	38-43	aquaporin 4	Homo sapiens	13-17
24999750-2	2014	Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of brain cells and the development of brain edema after TBI.	Water	127-132	aquaporin 4	Homo sapiens	0-11
24999750-2	2014	Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of brain cells and the development of brain edema after TBI.	Water	127-132	aquaporin 4	Homo sapiens	13-17
25754523-7	2015	Among KO mice, food consumption was unchanged, while water consumption was higher, over the duration of the experiment in CORT-treated animals, compared with untreated animals.	Water	53-58	cortistatin	Mus musculus	122-126
33817477-0	2021	Enhancement of Static and Dynamic Sag Performance of Water-Based Mud Using a Synthetic Clay.	Water	53-58	S-antigen visual arrestin	Homo sapiens	34-37
25490042-5	2015	Application in 5 kinds of natural water source and accurate detection of cyanide in tap water solvent system also indicated the high practical significance of the probe.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	84-87
25490042-5	2015	Application in 5 kinds of natural water source and accurate detection of cyanide in tap water solvent system also indicated the high practical significance of the probe.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
25156430-2	2014	We assessed the effects of PLP1 mutations on water diffusion in CNS white matter by using diffusion tensor imaging.	Water	45-50	proteolipid protein 1	Homo sapiens	27-31
33817477-8	2021	The synthetic clay was found to be effective in reducing the static and dynamic sag tendency of barite-weighted water-based drilling fluids.	Water	112-117	S-antigen visual arrestin	Homo sapiens	80-83
33814411-6	2021	The antioxidant effect of loading with water with saturation with molecular hydrogen leads to a decrease in the loss of sodium ions due to an improvement in its reabsorption and beta2-microglobulin in the proximal tubule, a decrease in lipid peroxidation in the renal cortex was noted, the degree of its damage by an increase in the K+/Na+ ratio and a decrease in degree of edema.	Water	39-44	beta-2 microglobulin	Rattus norvegicus	178-197
25486924-0	2015	Analysis of gadolinium-based contrast agents in tap water with a new hydrophilic interaction chromatography (ZIC-cHILIC) hyphenated with inductively coupled plasma mass spectrometry.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
25486924-5	2015	With the speciation method described, tap water samples from the area of Berlin were analysed and for the first time, three Gd species, Gd-BT-DO3A, Gd-DOTA and Gd-BOPTA, were found in tap water samples at concentrations of about 10-20 ng Gd per litre.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
33233609-6	2020	The corrosion process of each system was monitored by the corrosion potential and polarisation resistance during exposure to tap water and chloride solution over a period of almost one year.	Water	129-134	target of Poxn	Drosophila melanogaster	125-128
25266775-3	2015	The results showed that 75% of the university community drinks only bottled water and that the consumption of tap water is low.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	110-113
25266775-5	2015	In general, the participants in this study do not trust the quality of the tap water, which could be caused by the facilities that distribute bottled water encouraging a general disinterest in learning about the origin and management of the tap water that is distributed on campus.	Water	150-155	nuclear RNA export factor 1	Homo sapiens	241-244
25266775-5	2015	In general, the participants in this study do not trust the quality of the tap water, which could be caused by the facilities that distribute bottled water encouraging a general disinterest in learning about the origin and management of the tap water that is distributed on campus.	Water	150-155	nuclear RNA export factor 1	Homo sapiens	241-244
32795718-10	2020	Hence, this work provides a promising strategy to rapidly remove HRAs and significantly reduce their toxicity in water treatment.	Water	113-118	HRas proto-oncogene, GTPase	Homo sapiens	65-69
25062494-7	2015	Drinking tap water was significantly associated with an increased risk for gastroenteritis (relative risk 3 67, 95% confidence interval 2 86-4 70) as was place of residence.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
25062494-10	2015	Tap water samples tested positive for faecal indicator bacteria and protozoa.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
33032403-5	2020	The water mobility-represented by alpha as a function of ln tau-differed dramatically between the R (oxygenated) state and the T (deoxygenated) state of Hb at physiologically relevant concentrations (30 g/dl-35 g/dl or 4.5 mM-5.5 mM).	Water	4-9	microtubule associated protein tau	Homo sapiens	60-63
25814730-0	2015	Aquagenic keratoderma treated with tap water iontophoresis.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
25814730-4	2015	We report a case of AK unresponsive to topical 20% of aluminum chloride successfully treated with tap water iontophoresis.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
27898114-2	2017	A water-soluble VIEgen with a red fluorescence emission shows a pronounced, blue-shifted emission with Abeta peptide monomers and fibrils.	Water	2-7	amyloid beta (A4) precursor protein	Mus musculus	103-108
24738825-10	2015	CONCLUSION: Total daily fluoride (F) intake increased as F concentration in tap water increased.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
25766924-4	2015	A monomolecular micelle of ZPB formed in water with a mean size of 25 nm and zeta potential of -15 mV.	Water	41-46	zona pellucida glycoprotein 4	Homo sapiens	27-30
25792026-8	2015	Under the working conditions, the proposed methods were successfully applied to simultaneous determination of Hg2+, Cu2+, and Cd2+ in different water and soil samples.	Water	144-149	CD2 molecule	Homo sapiens	126-129
25857369-1	2015	Emerging evidence indicates that the water channel protein aquaporin 4 (AQP4) plays an essential role in water homeostasis and is implicated in the pathogenesis of brain edema.	Water	37-42	aquaporin 4	Homo sapiens	59-70
25857369-1	2015	Emerging evidence indicates that the water channel protein aquaporin 4 (AQP4) plays an essential role in water homeostasis and is implicated in the pathogenesis of brain edema.	Water	37-42	aquaporin 4	Homo sapiens	72-76
34968039-2	2022	Here, a luminescent 2D MOF nanosheet was designed and synthesized by a facile top-down strategy based on a three-dimensional (3D) layered MOF {(Zn(H2L)(H2O)2) H2O}n (Zn-MOF; H4L = 3,5-bis(3",5"-dicarboxyphenyl)-1H-1,2,4-triazole).	Water	152-155	H4 clustered histone 7	Homo sapiens	174-177
34968039-2	2022	Here, a luminescent 2D MOF nanosheet was designed and synthesized by a facile top-down strategy based on a three-dimensional (3D) layered MOF {(Zn(H2L)(H2O)2) H2O}n (Zn-MOF; H4L = 3,5-bis(3",5"-dicarboxyphenyl)-1H-1,2,4-triazole).	Water	159-162	H4 clustered histone 7	Homo sapiens	174-177
34968039-3	2022	With a large pi-conjugated system and rigid planar structure, ligand H4L was elaborately selected to construct the bulk Zn-MOF, which can be readily exfoliated into 2D nanosheets, owing to the weak interlayer interactions and easy-to-release H2O molecules in the interspaces of 2D layers.	Water	242-245	H4 clustered histone 7	Homo sapiens	69-72
34941278-8	2022	We demonstrate that ionization propensity, as measured by gas phase bacisity, can increase by over 100 kJ/mol when placed in a small water-serine cluster, showing the sensitivity of the chemistry of microsolvated analytes.	Water	133-138	gastrin	Homo sapiens	58-61
34426269-4	2022	Optimization of the analytical method was performed by spiking water with a mixture of all five pharmaceuticals at 500 ng mL-1.	Water	63-68	L1 cell adhesion molecule	Mus musculus	122-126
34426281-2	2022	The scope of this work is the development of a mechanistic biokinetic model, based on first principles and a robust thermodynamic basis, to provide a theoretical accurate description of a MET system that would treat water contaminated with nitrate, the most common aquifer water pollutant, in absence of external electron donors.	Water	216-221	SAFB like transcription modulator	Homo sapiens	188-191
34426281-2	2022	The scope of this work is the development of a mechanistic biokinetic model, based on first principles and a robust thermodynamic basis, to provide a theoretical accurate description of a MET system that would treat water contaminated with nitrate, the most common aquifer water pollutant, in absence of external electron donors.	Water	273-278	SAFB like transcription modulator	Homo sapiens	188-191
34347242-6	2022	In addition, the detection of RAAS-related genes (AGT gene in the liver, REN in the kidney, ACE in the lung) demonstrates that after using salt-contaminated water, the transcription levels of AGT, REN, and ACE rise significantly, and the concentration of angiotensin II (Ang II) also increases significantly.	Water	157-162	renin	Gallus gallus	73-76
34347242-6	2022	In addition, the detection of RAAS-related genes (AGT gene in the liver, REN in the kidney, ACE in the lung) demonstrates that after using salt-contaminated water, the transcription levels of AGT, REN, and ACE rise significantly, and the concentration of angiotensin II (Ang II) also increases significantly.	Water	157-162	angiotensin I converting enzyme	Gallus gallus	92-95
34347242-6	2022	In addition, the detection of RAAS-related genes (AGT gene in the liver, REN in the kidney, ACE in the lung) demonstrates that after using salt-contaminated water, the transcription levels of AGT, REN, and ACE rise significantly, and the concentration of angiotensin II (Ang II) also increases significantly.	Water	157-162	renin	Gallus gallus	197-200
34347242-6	2022	In addition, the detection of RAAS-related genes (AGT gene in the liver, REN in the kidney, ACE in the lung) demonstrates that after using salt-contaminated water, the transcription levels of AGT, REN, and ACE rise significantly, and the concentration of angiotensin II (Ang II) also increases significantly.	Water	157-162	angiotensin I converting enzyme	Gallus gallus	206-209
34822830-8	2022	Therefore, polysaccharides extracted by water and alkaline solvents from Evodiae fructus could be developed as promising natural antioxidants and alpha-glucosidase inhibitors in the food and medicine industries.	Water	40-45	sucrase-isomaltase	Homo sapiens	146-163
34963692-0	2021	The activity of the intrinsically water-soluble enzyme ADAMTS13 correlates with the membrane state when bound to a phospholipid bilayer.	Water	34-39	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	55-63
34939236-1	2022	Magnetization transfer contrast MR fingerprinting (MTC-MRF) is a novel quantitative imaging method that simultaneously quantifies free bulk water and semisolid macromolecule parameters using pseudo-randomized scan parameters.	Water	140-145	myelin regulatory factor	Homo sapiens	55-58
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	mitogen-activated protein kinase 1	Arabidopsis thaliana	461-493
25089785-1	2014	The optimization of a gelled oil-in-water emulsion was performed for use as fat replacer in the formulation of omega-3 PUFA-enriched cooked meat products.	Water	36-41	pumilio RNA binding family member 3	Homo sapiens	119-123
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	mitogen-activated protein kinase 1	Arabidopsis thaliana	495-499
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	mitogen-activated protein kinase 1	Arabidopsis thaliana	567-571
25089785-7	2014	The selected optimized gelled oil-in-water emulsion was demonstrated to be a suitable lipophilic delivery system for omega-3 PUFA compounds and applicable in food formulations as fat replacer.	Water	37-42	pumilio RNA binding family member 3	Homo sapiens	125-129
34988095-10	2021	SGLT2i improve blood pressure through a negative sodium and water balance and possibly by inhibiting the sympathetic nervous system.	Water	60-65	solute carrier family 5 member 2	Homo sapiens	0-5
25217752-0	2014	Phthalate occurrence in rivers and tap water from central Spain.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
25217752-5	2014	The DBP was found to make the highest average contribution to pollution in both river and tap water.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
25217752-9	2014	A preliminary risk assessment suggested that the risk of exposure to phthalates from tap water in this study is acceptable, although continuous monitoring of the presence of these substances in both drinking and river water should be undertaken to detect possible increases in their concentrations.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
25902645-0	2014	[Determination of phenol in water by electrochemical tyrosinase biosensor based on ordered graphitized mesoporous carbon and evaluated by high performance liquid chromatography].	Water	28-33	tyrosinase	Homo sapiens	53-63
25902645-9	2014	The comparative study between HPLC and GMC-based tyrosinase biosensor showed that the detection of phenol in water sample by the GMC-based tyrosinase biosensor method is reliable, accurate and effective.	Water	109-114	tyrosinase	Homo sapiens	49-59
34428660-4	2021	To combat these effects, green infrastructure (GI) practices, like water harvesting rain gardens, are implemented in the Southwest United States to restore natural ecological function, yet little is known about how GI impacts soil health.	Water	67-72	G protein subunit alpha i1	Homo sapiens	47-49
25902645-9	2014	The comparative study between HPLC and GMC-based tyrosinase biosensor showed that the detection of phenol in water sample by the GMC-based tyrosinase biosensor method is reliable, accurate and effective.	Water	109-114	tyrosinase	Homo sapiens	139-149
25258405-9	2014	Myo5b kd cells showed a decrease in net water absorption that could be reverted with PDK1 inhibitors.	Water	40-45	pyruvate dehydrogenase kinase 1	Homo sapiens	85-89
34933759-5	2022	RESULTS: After 9 weeks of standardized cholesterol esterase (CEase) exposure, EGDMA discs showed exponential loss of material (p = 0.0296), strength (p = 0.0014) and increased water sorption (p = 0.0002) compared to EGEMA discs.	Water	176-181	carboxyl ester lipase	Homo sapiens	39-59
25220287-7	2014	40-fold excess of water and conducted in acetone at 60  C (R2 = Me2, C5H10) or 80  C (R2 = Ph2) in closed vials, and it gives the urea complexes [ZnX2{OC(NR2)NH2}] (R2 = Me2, X = Cl , X = Br , X = I ; R = C5H10, X = Cl , X = Br ; X = I ; R2 = Ph2, X = Cl , X = Br , X = I ; 57-81%).	Water	18-23	polyhomeotic homolog 2	Homo sapiens	91-94
25220287-7	2014	40-fold excess of water and conducted in acetone at 60  C (R2 = Me2, C5H10) or 80  C (R2 = Ph2) in closed vials, and it gives the urea complexes [ZnX2{OC(NR2)NH2}] (R2 = Me2, X = Cl , X = Br , X = I ; R = C5H10, X = Cl , X = Br ; X = I ; R2 = Ph2, X = Cl , X = Br , X = I ; 57-81%).	Water	18-23	polyhomeotic homolog 2	Homo sapiens	243-246
34933759-5	2022	RESULTS: After 9 weeks of standardized cholesterol esterase (CEase) exposure, EGDMA discs showed exponential loss of material (p = 0.0296), strength (p = 0.0014) and increased water sorption (p = 0.0002) compared to EGEMA discs.	Water	176-181	carboxyl ester lipase	Homo sapiens	61-66
34913578-3	2022	The as-fabricated electrode of CoP@CF-900, when used as both the cathode and anode for overall water splitting, is able to deliver 200 mA cm-2 at a cell voltage of 1.89 V, significantly outshining the Pt/C  RuO2 couple; when used as the air cathode for a zinc-air battery, is able to operate more than 150 h at 10 mA cm-2 with a nearly constant round-trip energy efficiency of  60%, also outperforming the Pt/C+RuO2 benchmark.	Water	95-100	caspase recruitment domain family member 16	Homo sapiens	31-34
23982198-1	2014	Aquaporin-4 (AQP4) water channels are concentrated in astrocytic endfoot membranes at the brain-blood and brain-cerebrospinal fluid interfaces.	Water	19-24	aquaporin 4	Mus musculus	0-11
23982198-1	2014	Aquaporin-4 (AQP4) water channels are concentrated in astrocytic endfoot membranes at the brain-blood and brain-cerebrospinal fluid interfaces.	Water	19-24	aquaporin 4	Mus musculus	13-17
34426326-2	2021	In this study, different types of spectroscopy including ultraviolet-visible absorption, Fourier transform infrared, and fluorescence spectroscopy was used to investigate the binding characteristics of Fe3+, Cu2+, Cr3+, Cd2+, and Zn2+ with DOM from wetland water.	Water	257-262	CD2 molecule	Homo sapiens	220-223
25261362-11	2014	For an ultra-short irradiation time of 1 s at 1000 mW/cm(2), TPO-composites displayed similar polymerization stresses compared to CQ-controls with yet a 25% increase for flexural modulus and 40% increase for hardness measured after EtOH/H2O sorption.	Water	237-240	thyroid peroxidase	Homo sapiens	61-64
34826320-9	2021	Therefore, CP 2 is a suitable candidate for advanced practical applications for the efficient sensing of tryptophan in water.	Water	119-124	ceruloplasmin	Homo sapiens	11-15
25373994-0	2014	Geoacoustic inversion of ship radiated noise in shallow water using data from a single hydrophone.	Water	56-61	inositol polyphosphate-5-phosphatase D	Homo sapiens	25-29
25546315-7	2015	The method was also evaluated for the analysis of tap water and cooling water samples treated with the biocide.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
34846399-0	2021	Construction of Fe-doped CoP with hybrid nanostructures as a bifunctional catalyst for overall water splitting.	Water	95-100	caspase recruitment domain family member 16	Homo sapiens	25-28
26388586-3	2014	The discovery of an autoantibody called NMO-IgG, which targets aquaporin-4, the main water channel in the CNS, gave a new direction to understanding the underlying immunologic mechanisms.	Water	85-90	aquaporin 4	Homo sapiens	63-74
34846399-3	2021	The as-synthesized Fe0.25-CoP catalyst exhibits remarkable catalytic performance and durability at overpotentials of 262 mV for the OER and 111 mV for the HER, requiring a voltage of merely 1.57 V to achieve a current density of 10 mA cm-2 for the electrocatalytic water splitting process.	Water	265-270	caspase recruitment domain family member 16	Homo sapiens	26-29
25093213-3	2014	At a platinum electrode in bis(trifluoromethylsulfonyl)imide (NTf2)-based ILs, methane is electro-oxidized to produce CO2 and water when an oxygen reduction process is included.	Water	126-131	nuclear transport factor 2	Homo sapiens	62-66
25587180-3	2015	The 1.8 A crystal structure of Msl5-(KH-QUA2) bound to the branchpoint highlights an extensive network of direct and water-mediated protein-RNA and intra-RNA atomic contacts at the interface that illuminate how Msl5 recognizes each nucleobase of the UACUAAC element.	Water	117-122	mRNA splicing protein MSL5	Saccharomyces cerevisiae S288C	31-35
25587180-3	2015	The 1.8 A crystal structure of Msl5-(KH-QUA2) bound to the branchpoint highlights an extensive network of direct and water-mediated protein-RNA and intra-RNA atomic contacts at the interface that illuminate how Msl5 recognizes each nucleobase of the UACUAAC element.	Water	117-122	mRNA splicing protein MSL5	Saccharomyces cerevisiae S288C	211-215
34966284-5	2021	The results suggested that microinjected of Abeta into CA1 of hippocampus induced cognitive and memory impairment in mice, as evidenced by decreased recognition index in the novel object recognition (NOR) task, impaired memory acquisition, retention and retrieval in the Morris water maze (MWM) and shuttle box tests.	Water	278-283	amyloid beta (A4) precursor protein	Mus musculus	44-49
25279561-1	2014	Tap water (unfiltered), filtered tap water and processed bottled water (purified water, artificial mineralized water, or natural water) are now the five most widely consumed types of drinking water in China.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
25279561-4	2014	The results showed that the unfiltered tap water group had the lowest values for the maternal gestation index (MGI) and offspring"s learning and memory abilities (OLMA); the lowest offspring survival rate was found in the purified water group; and the highest OLMA were found in the filtered tap water group.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
25279561-4	2014	The results showed that the unfiltered tap water group had the lowest values for the maternal gestation index (MGI) and offspring"s learning and memory abilities (OLMA); the lowest offspring survival rate was found in the purified water group; and the highest OLMA were found in the filtered tap water group.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	292-295
25279561-4	2014	The results showed that the unfiltered tap water group had the lowest values for the maternal gestation index (MGI) and offspring"s learning and memory abilities (OLMA); the lowest offspring survival rate was found in the purified water group; and the highest OLMA were found in the filtered tap water group.	Water	231-236	nuclear RNA export factor 1	Homo sapiens	39-42
25279561-4	2014	The results showed that the unfiltered tap water group had the lowest values for the maternal gestation index (MGI) and offspring"s learning and memory abilities (OLMA); the lowest offspring survival rate was found in the purified water group; and the highest OLMA were found in the filtered tap water group.	Water	231-236	nuclear RNA export factor 1	Homo sapiens	39-42
25279561-5	2014	Thus, the best reproductive and offspring early developmental outcomes were found in the group that drank filtered tap water, which had the lowest levels of pollutants and the richest minerals.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
25658518-1	2015	Remarkable hydrogen evolution reaction (HER) or superior oxygen evolution reaction (OER) catalyst has been applied in water splitting, however, utilizing a bifunctional catalyst for simultaneously generating H2 and O2 is still a challenging issue, which is crucial for improving the overall efficiency of water electrolysis.	Water	118-123	relaxin 2	Homo sapiens	208-217
25658518-1	2015	Remarkable hydrogen evolution reaction (HER) or superior oxygen evolution reaction (OER) catalyst has been applied in water splitting, however, utilizing a bifunctional catalyst for simultaneously generating H2 and O2 is still a challenging issue, which is crucial for improving the overall efficiency of water electrolysis.	Water	305-310	relaxin 2	Homo sapiens	208-217
34823359-2	2021	In the electrochemical (EC) reaction using F-doped SnO2 (FTO) substrates and a 0.5 M H2SO4 H2O-acetone (60 vol %) mixed solution containing 5 mM naphthalene, we produced a small amount of naphthoquinone evolution in the dark.	Water	91-94	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	57-60
26278453-1	2014	The influence of nanoconfinement on water structure is studied with time- and frequency-resolved vibrational spectroscopy of hydrazoic acid (HN3) encapsulated in reverse micelle.	Water	36-41	MT-RNR2 like 3 (pseudogene)	Homo sapiens	141-144
26278453-2	2014	The azido stretch mode of HN3 is found to be a promising infrared probe for studying the structure and local hydrogen-bond environment of confined and interfacial water in reverse micelle due to its narrow spectral bandwidth and large transition dipole moment.	Water	163-168	MT-RNR2 like 3 (pseudogene)	Homo sapiens	26-29
25240833-1	2015	The mineral yuksporite (K,Ba)NaCa2(Si,Ti)4O11(F,OH) H2O has been studied using the combination of SEM with EDX and vibrational spectroscopic techniques of Raman and infrared spectroscopy.	Water	52-55	nascent polypeptide associated complex subunit alpha 2	Homo sapiens	29-34
34960272-2	2021	This paper proposes a novel wireless multi-sensor system by integrating the temperature, pH, DO, and EC sensors with an ESP 32 Wi-Fi module for monitoring the water quality of freshwater aquaculture, which acquires the sensing data and salinity information directly derived from the EC level.	Water	159-164	colipase like 1	Homo sapiens	120-126
25634730-1	2015	Bronsted acid p-TsOH H2O-catalyzed hydrovinylation of styrenes with internal olefins alpha-oxo ketene dithioacetals was efficiently achieved in the presence of N-phenylselenophthalimide (N-PSP), regioselectively affording Markovnikov phenylselenative hydrovinylation products through PhSe transfer of the phenylseleno ketene dithioacetal intermediates.	Water	21-24	microseminoprotein beta	Homo sapiens	189-192
25328178-4	2014	GAB model coefficients revealed that water adsorption by cheese matrix is a multilayer process characterized by molecules that are strongly bound in the monolayer and molecules that are slightly structured in a multilayer.	Water	37-42	alpha-1-B glycoprotein	Homo sapiens	0-3
34753585-2	2021	Herein, the dht ligand containing hydroxy group (-OH) is used to design and synthesize a 2D luminescent (Cd2(idc)(dht)(H2O)4) (1); H2idc = 4,5-imidazoledicarboxylic acid and H2dht = 2,5-dihydroxyterephthalic acid for sensing amino acids.	Water	119-122	CD2 molecule	Homo sapiens	105-108
25102910-10	2014	Nursing staff should pay special attention to children and immunosuppressed patients in terms of tap-water exposure and also their personal hygiene, and should regularly use sterile water for rinsing/cleaning devices.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
25692550-2	2015	EAU was induced in P2Y2+/+ and P2Y2-/- mice by immunization with IRBP peptide or by adoptive transfer of in vitro restimulated semi-purified IRBP-specific enriched T lymphocytes from spleens and lymph nodes isolated from native C57Bl/6 or P2Y2+/+ and P2Y2-/- immunized mice.	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	65-69
25692550-2	2015	EAU was induced in P2Y2+/+ and P2Y2-/- mice by immunization with IRBP peptide or by adoptive transfer of in vitro restimulated semi-purified IRBP-specific enriched T lymphocytes from spleens and lymph nodes isolated from native C57Bl/6 or P2Y2+/+ and P2Y2-/- immunized mice.	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	141-145
34717965-9	2021	IGF-1 induced activation of YAP/TAZ, which resulted in improved cell viability in vitro, and reduced neurological deficits, brain water content, neuronal death and apoptosis, and cerebral infarct volume in vivo.	Water	130-135	insulin-like growth factor 1	Rattus norvegicus	0-5
25462307-8	2015	A C-H bond of the methoxyl is activated by Compound I, followed by radical rebound to form carbinol intermediates, then the carbinols decompose to form 6-HO-BDE-47 with the assistance of water molecules.	Water	187-192	homeobox D13	Homo sapiens	157-160
25371524-2	2014	CaRs stimulation leads to PGE2-mediated decrease in protein content of Na(+)-K(+)-2Cl(-) co-transporters (BSC-1) in the thick ascending limb (TAL) of Henle"s loop and of aquaporin 2 (AQP2) water channels in collecting ducts.	Water	189-194	solute carrier family 12 member 1	Rattus norvegicus	106-111
34353139-4	2021	RESULTS: At 6 h, 12 h, 24 h, 3 days, and 7 days after mice with MCAO, CBX7 expression was gradually up-regulated and the peak level was reached at 24 h. Mice in the WT + MCAO group had increased infarct size, with significant increases in the modified neurological severity scores and water content in the brain, as well as the quantity of TUNEL-positive cells.	Water	285-290	chromobox 7	Mus musculus	70-74
25082269-9	2014	Our data show that both isoforms facilitate transmembrane water diffusion in the presence of the ZmPIP2;1 isoform.	Water	58-63	aquaporin PIP2-1	Zea mays	97-105
25236939-6	2015	RESULTS: Statistical analysis demonstrated that tap water, saline, and saliva decreased cell viability as the storage temperature increased.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
25556814-5	2015	RESULTS: Oral administration of Harkany thermal spring water significantly attenuated general signs of colitis, MPO enzyme activity of colon samples and detrimental effect of colitis on the function of the enteric nervous system, but not histological signs of colitis.	Water	55-60	myeloperoxidase	Mus musculus	112-115
25059148-1	2014	This article investigates the flow injection analysis of mercury (II) ions in tap water samples via surface Plasmon resonance detection.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
34823029-8	2021	The occurrence of MDR E. coli co-harboring mcr-1.1, blaCTX-M-2, and blaCMY-2 in urban water represents a potential risk to humans, animals, and environmental safety.	Water	86-91	AmpC	Escherichia coli	68-76
25059148-6	2014	The accurate determination of mercury (II) ions in samples of unknown composition is demonstrated with a fortified tap water sample.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
25341358-4	2014	In healthy animals drinking tap water, oral citrate administration increased aluminum absorption and, over a 4-week period, increased aluminum deposition in brain and bone by about 2- and 20-fold, respectively.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
34731658-9	2021	Sediments generally functioned as a sink for Cd in winter and shifted to acting as a source in summer, releasing Cd into the overlying water mainly as Cd-S complexes with high potential to migrate downstream.	Water	135-140	CDP-diacylglycerol synthase 1	Homo sapiens	151-155
25505081-7	2015	Residues from both monomers contributed to the HBGA binding and involved a network of direct hydrogen bonds and water-mediated interactions.	Water	112-117	hemoglobin subunit gamma 1	Homo sapiens	47-51
34247080-7	2021	Water flow regimes within dumps are dominated by matrix and/or preferential flow, depending on dump texture; these flow mechanisms exert a primary control on patterns of aqueous COI release.	Water	0-5	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	178-181
24967824-4	2015	The patients were instructed to dilute 1 ampulla of TXA in 300 ml of tap water (concentration 0.2%) from postoperative day 5-10 and to gargle or spray the tonsillar fossae 5-6 times daily.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
24690560-6	2014	The selectivity relative to other potentially interfering ions and the applicability in real samples, human serum and tap water, have also been evaluated.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
25146699-4	2014	We also show that, in cultured primary astrocytes: (i) both CRFR1 and AQP4 are expressed; (ii) exogenous CRF, acting through CRFR1, triggers signaling of cAMP/PKA, intracellular Ca(2+), and PKCepsilon; and (iii) the up-regulated cAMP/PKA signaling contributes to the phosphorylation and expression of AQP4 to enhance water influx into astrocytes and produces an up-regulation of ET-1 expression.	Water	317-322	corticotropin releasing hormone receptor 1	Rattus norvegicus	125-130
26137696-1	2015	For understanding the effect of MDG-1, a water-soluble beta-D-fructan polysaccharide from Ophiopogon japonicas, on intestinal microecological balance, especially on the changes of lactobacillus, sixty 8-week-old male C57BL/6J mice were given a high-fat diet for six weeks and were also gavaged with saline once a day simultaneously.	Water	41-46	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	32-37
34764256-4	2021	Our results indicate that the O1 channel is the likely water intake pathway, and the Cl1 channel is the likely proton release pathway based on the structural rearrangements of water molecules and amino acid side chains along these channels.	Water	176-181	adhesion G protein-coupled receptor L1	Homo sapiens	85-88
25555212-1	2015	We present our studies on the physicochemical properties of water confined in Dibutylimidazolium bis(trifluoromethanesulfonylimide) ([C4C4im][NTf2]) reverse micelles through the NMR relaxation measurements that provide us an understanding of microviscosity and pH in the confined condition.	Water	60-65	nuclear transport factor 2	Homo sapiens	142-146
24925575-8	2014	These findings shed light on the intrinsic and environmental factors that promote the spontaneous conversion of CLIC1 from a water-soluble to a membrane-bound protein.	Water	125-130	chloride intracellular channel 1	Homo sapiens	112-117
34633393-5	2021	The cut-off limit of the strip is 10 ng mL-1 in water, and concentrations as low as 1 ng mL-1 can be detected in herbal tea samples, with the results obtained by the naked eye within 6 min.	Water	48-53	L1 cell adhesion molecule	Mus musculus	40-44
25218094-2	2014	This cell line was chosen since ingestion of contaminated food/water represents an important route of exposure to both Cd and BDE-209, which is why intestinal cells are a common target for the contaminants present in food and water.	Water	63-68	homeobox D13	Homo sapiens	126-129
25218094-2	2014	This cell line was chosen since ingestion of contaminated food/water represents an important route of exposure to both Cd and BDE-209, which is why intestinal cells are a common target for the contaminants present in food and water.	Water	226-231	homeobox D13	Homo sapiens	126-129
25613130-6	2015	Under external hypertonicity, loss of ine in the hindgut epithelium results in severe dehydration without damage to the hindgut epithelial cells, implicating a physiological failure of water conservation/absorption.	Water	185-190	inebriated	Drosophila melanogaster	38-41
25613130-7	2015	We also found that hindgut expression of ine is required for water conservation under desiccating conditions.	Water	61-66	inebriated	Drosophila melanogaster	41-44
25613130-8	2015	Importantly, specific expression of ine in the hindgut epithelium can completely restore disrupted systemic water homeostasis in ine mutants under both conditions.	Water	108-113	inebriated	Drosophila melanogaster	36-39
25613130-8	2015	Importantly, specific expression of ine in the hindgut epithelium can completely restore disrupted systemic water homeostasis in ine mutants under both conditions.	Water	108-113	inebriated	Drosophila melanogaster	129-132
25518681-1	2014	This research used batch soil column experiment to study the effects of irrigating with reclaimed water and tap water on the soil chemical properties and culturable microorganisms.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
25518681-4	2014	The dominant bacteria in tap water irrigation area was the genus Bacillus whereas that of reclaimed water irrigation area was the genus Acinetobacter.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
34750450-3	2021	BALB/c mice were bathed in neutral bicarbonate ionized water (NBIW) and showed increased blood bicarbonate levels and blood flow via phosphorylation of peripheral vascular endothelial nitric oxide synthase (eNOS) and production of nitric oxide (NO).	Water	55-60	nitric oxide synthase 3, endothelial cell	Mus musculus	172-205
25174944-2	2014	This enzyme catalyzes the syn-addition of a water molecule across the double bond of 4-(N,N-dimethylamino) cinnamoyl-CoA (DAC-CoA).	Water	44-49	synemin	Homo sapiens	26-29
25395044-2	2015	We present a model for the binding of morphinan ligands and JDTic to the JDTic/KOR crystal structure based on an atomic level description of the water structure within its active site.	Water	145-150	opioid receptor kappa 1	Homo sapiens	79-82
26401744-10	2015	CPAP can be generated in three manners: directly by the ventilator; through the use of a CPAP valve with a reservoir; and through the use of a highly traditional T-piece system with a reservoir bag connected to distal tubing immersed in water.	Water	237-242	centromere protein J	Homo sapiens	0-4
24810629-5	2014	A homology search indicated that ORF32 encodes a hydratase for the CoA-ester, suggesting that ORF32 encodes a hydratase that adds a water molecule to a double bond at C-6 of the CoA-ester of 9alpha-hydroxy-17-oxo-1,2,3,4,10,19-hexanorandrost-6-en-5-oic acid.	Water	132-137	Orf32	Comamonas testosteroni	33-38
34750450-3	2021	BALB/c mice were bathed in neutral bicarbonate ionized water (NBIW) and showed increased blood bicarbonate levels and blood flow via phosphorylation of peripheral vascular endothelial nitric oxide synthase (eNOS) and production of nitric oxide (NO).	Water	55-60	nitric oxide synthase 3, endothelial cell	Mus musculus	207-211
24810629-5	2014	A homology search indicated that ORF32 encodes a hydratase for the CoA-ester, suggesting that ORF32 encodes a hydratase that adds a water molecule to a double bond at C-6 of the CoA-ester of 9alpha-hydroxy-17-oxo-1,2,3,4,10,19-hexanorandrost-6-en-5-oic acid.	Water	132-137	Orf32	Comamonas testosteroni	94-99
34832082-6	2021	In addition, PANI-MWCNT-APTES/GCE was harnessed for the first time for cadmium detection in real water samples, and the result was satisfactory.	Water	97-102	aminomethyltransferase	Homo sapiens	30-33
24911889-0	2014	Concentration of enteric viruses from tap water using an anion exchange resin-based method.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
24911889-4	2014	Ten liter samples of tap water spiked with different concentrations (10-10,000 TCID50/10 L) of human adenovirus 40 (HAdV-40), hepatitis A virus (HAV) or rotavirus (RV) were concentrated and detected by real time PCR or real time RT-PCR.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
25093550-7	2014	However, tap water was a major contributor to PFOA intake when it was the main source of drinking water (rather than bottled water).	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
25093550-7	2014	However, tap water was a major contributor to PFOA intake when it was the main source of drinking water (rather than bottled water).	Water	98-103	nuclear RNA export factor 1	Homo sapiens	9-12
25093550-7	2014	However, tap water was a major contributor to PFOA intake when it was the main source of drinking water (rather than bottled water).	Water	98-103	nuclear RNA export factor 1	Homo sapiens	9-12
25313320-0	2014	Novel Type of Prodrug Activation through a Long-Range O,N-Acyl Transfer: A Case of Water-Soluble CREB Inhibitor.	Water	83-88	cAMP responsive element binding protein 1	Homo sapiens	97-101
25313320-4	2014	In this report, we described a water-soluble inhibitor (compound 6) of CREB-mediated gene transcription with in vivo anticancer activity.	Water	31-36	cAMP responsive element binding protein 1	Homo sapiens	71-75
24977405-5	2014	Herein, we report the synthesis of cell-permeable, water-soluble amphiphilic porphyrin - Plk1 specific peptide bioconjugates, Por-P1 and Por-P2.	Water	51-56	polo like kinase 1	Homo sapiens	89-93
25069056-5	2014	By the combination of planar chromatography, using water-wettable reversed phase high-performance thin-layer chromatography (HPTLC RP18 W) plates, with detection by specific microorganisms, endocrine compounds in food were quantitatively detected as sharp-bounded zones and further characterized by mass spectrometry.	Water	51-56	pre-mRNA processing factor 3	Homo sapiens	131-135
24879973-7	2014	The increased expression of AQP5 at 24h in control mice might be due to its regulation in transcellular water reabsorption.	Water	104-109	aquaporin 5	Mus musculus	28-32
23764723-2	2014	Once considered a subtype of multiple sclerosis, neuromyelitis optica, is now known to have a discrete pathogenesis in which antibodies to the water channel, aquaporin 4, play a critical role.	Water	143-148	aquaporin 4	Homo sapiens	158-169
24907161-7	2014	One subgroup was stored for 3 days in 37 C tap water and the other subgroup was stored for 150 days in 37 C tap water interrupted by 37,500 thermal cycles between 5 C and 55 C. After the storage, the bond strength was measured using a material testing machine.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
24981569-6	2014	Overall (d 0 to 24), pigs drinking sodium sulfate water had decreased (P &lt; 0.01) ADG, ADFI, and G:F compared with pigs drinking control water.	Water	50-55	ADG	Sus scrofa	84-87
24981569-11	2014	Overall (d 0 to 21), a water source x diet interaction was observed for ADG and G:F because pigs fed the 1% HA had decreased (P &lt; 0.01) ADG and G:F when drinking sodium sulfate water compared with other treatments but increased ADG and G:F when drinking control water.	Water	23-28	ADG	Sus scrofa	72-75
24981569-12	2014	Pigs drinking sodium sulfate water had decreased (P &lt; 0.01) ADG and G:F and tended (P &lt; 0.08) to have decreased ADFI compared with pigs drinking control water.	Water	29-34	ADG	Sus scrofa	63-66
25162736-1	2014	BACKGROUND: Many people use bottled water instead of tap water for many reasons such as taste, ease of carrying, and thinking that it is safer than tap water.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
25162736-1	2014	BACKGROUND: Many people use bottled water instead of tap water for many reasons such as taste, ease of carrying, and thinking that it is safer than tap water.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
25935978-2	2014	MiR-122 has been considered to be specifically expressed in liver and involved in inducing hepatocyte apoptosis through bcl-w pathway, which could be efficiently bound to water dispersible positively charged gold nanoparticles and conjugated with folic acid (FA) to target specific cancer cells, through complementary electrostatic interaction.	Water	171-176	microRNA 122	Homo sapiens	0-7
24992591-2	2014	In this work, we employ molecular dynamics simulations to characterize the influence of various water concentrations on nanostructural properties of the 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [Hmim][NTf2] IL.	Water	96-101	nuclear transport factor 2	Homo sapiens	222-226
24992591-3	2014	An examination of molecular interactions in [Hmim][NTf2] IL-water mixtures shows the following trends: (a) At low water concentration, small regions of water molecules are surrounded by several cation-anion pairs.	Water	60-65	nuclear transport factor 2	Homo sapiens	51-55
25010870-0	2014	Water-stable three-dimensional ultrafine fibrous scaffolds from keratin for cartilage tissue engineering.	Water	0-5	keratin	Gallus gallus	64-71
25010870-1	2014	Intrinsically water-stable scaffolds composed of ultrafine keratin fibers oriented randomly and evenly in three dimensions were electrospun for cartilage tissue engineering.	Water	14-19	keratin	Gallus gallus	59-66
25010870-9	2014	Due to the highly cross-linked molecular structures, keratin scaffolds showed intrinsic water stability.	Water	88-93	keratin	Gallus gallus	53-60
24583689-8	2014	The SPR biosensor is characterized for 5 different heavy metal ions, Cu(2+), Fe(3+), Mn(2+), Pb(2+), and Hg(2+), most common heavy metal ions found in tap water.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	151-154
26586927-8	2015	The Chd7 gene, essential for neural crest cell migration and patterning, was found to be hypomethylated in each experimental animal tested compared to water-treated controls.	Water	151-156	chromodomain helicase DNA binding protein 7	Mus musculus	4-8
25180822-0	2015	Pentafluorobenzyl esterification of haloacetic acids in tap water for simple and sensitive analysis by gas chromatography/mass spectrometry with negative chemical ionization.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
25180822-9	2015	The method was applied to 30 tap water samples from 15 cities in the Kansai region of Japan.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
25180822-11	2015	Dichloroacetic acid, trichloroacetic acid, and bromochloroacetic acid were the major HAAs detected in most of the tap water, and accounted for 29%, 20% and 19% of the total HAAs, respectively.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
25460755-0	2015	TNT and RDX degradation and extraction from contaminated soil using subcritical water.	Water	80-85	radixin	Homo sapiens	8-11
25460755-4	2015	In the SCWE experiments, near complete degradation of both TNT and RDX was observed at 175  C based on analysis of water extracts and soil.	Water	115-120	radixin	Homo sapiens	67-70
25514858-3	2015	Remarkable temporal and spatial variations were observed among most of the trace elements in the tap water collected from two tap water treatment plants.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
25447156-1	2015	The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial chloride channel regulating the transepithelial transport of electrolyte and water.	Water	157-162	cystic fibrosis transmembrane conductance regulator	Mus musculus	4-55
25447156-1	2015	The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial chloride channel regulating the transepithelial transport of electrolyte and water.	Water	157-162	cystic fibrosis transmembrane conductance regulator	Mus musculus	57-61
26400087-5	2015	Zn(OTf)2 gave an overall propylene carbonate yield of greater than 50% in 24 h, twice as large as the previous best literature yield with MeCN as a water trap, with 69% selectivity and 75% conversion of propylene glycol at 145  C and 50 bar CO2 pressure.	Water	148-153	POU class 2 homeobox 2	Homo sapiens	3-8
25568368-4	2015	Tap water was provided and consumption measured.	Water	4-9	putative ABC-transporter	Sus scrofa	0-3
26074054-0	2015	[Hygienic maintenance of water mist-generating equipment that couples directly to the tap].	Water	25-30	nuclear RNA export factor 1	Homo sapiens	86-89
26074054-1	2015	OBJECTIVES: Water mist is usually generated using equipment directly connected to the water tap, as its installation is relatively easy.	Water	12-17	nuclear RNA export factor 1	Homo sapiens	92-95
26074054-1	2015	OBJECTIVES: Water mist is usually generated using equipment directly connected to the water tap, as its installation is relatively easy.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	92-95
26102586-5	2015	The GmWRKY53-interacting proteins also included 3 water stress-inducible AP2/ERF transcription factors.	Water	50-55	floral homeotic protein APETALA 2	Glycine max	73-76
25714644-5	2015	The proposed CE method was successfully applied for the analysis of samples of tap water and cooling water spiked with DBNPA.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
25372899-2	2014	We separate the spectra of the two possible structural isomers, syn- and anti-CH3CHOO, based on their different reactivity towards H2O and SO2.	Water	131-134	synemin	Homo sapiens	64-67
25471579-0	2014	Endogenous glucagon-like peptide-1 reduces drinking behavior and is differentially engaged by water and food intakes in rats.	Water	94-99	glucagon	Rattus norvegicus	11-34
25471579-8	2014	Subsequent experiments showed that water intake had a selective effect on central GLP-1-related gene expression, unlike food intake, which affected both central and peripheral GLP-1.	Water	35-40	glucagon	Rattus norvegicus	82-87
25471579-9	2014	Although water and food intakes both affected central GLP-1-relevant gene expression, there were notable differences in the timing of the effect.	Water	9-14	glucagon	Rattus norvegicus	54-59
25056753-4	2014	In Pakistan, water at the source, in the distribution network, and at the consumer tap is heavily polluted with coliforms and fecal coliforms all over the country.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	83-86
25521734-1	2014	BACKGROUND AND AIM: Basolateral water channel, aquaporin-4 (AQP4), is known to be expressed in gastric parietal cells, especially in the basal side of gastric mucosa.	Water	32-37	aquaporin 4	Mus musculus	47-58
25521734-1	2014	BACKGROUND AND AIM: Basolateral water channel, aquaporin-4 (AQP4), is known to be expressed in gastric parietal cells, especially in the basal side of gastric mucosa.	Water	32-37	aquaporin 4	Mus musculus	60-64
25463674-1	2014	Here, we used a strategy to answer to the question that whether Ca(II) ion is specific for water oxidation or not?	Water	91-96	carbonic anhydrase 2	Homo sapiens	64-70
25463674-3	2014	We proposed that Ca(II), K(I), Mg(II), La(III) and Ni(II), between layers are important to form efficient water-oxidizing catalyst, but not specific in water oxidation.	Water	106-111	carbonic anhydrase 2	Homo sapiens	17-23
25463674-3	2014	We proposed that Ca(II), K(I), Mg(II), La(III) and Ni(II), between layers are important to form efficient water-oxidizing catalyst, but not specific in water oxidation.	Water	152-157	carbonic anhydrase 2	Homo sapiens	17-23
25498933-7	2014	One test group washed their hands with standing water, and the other with running tap water.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
24888581-0	2014	Probing water density and dynamics in the chaperonin GroEL cavity.	Water	8-13	heat shock protein family D (Hsp60) member 1	Homo sapiens	53-58
24888581-5	2014	Residue 71 in GroES is fully exposed to bulk water in free GroES and to confined water within the cavity of the GroEL-GroES complex.	Water	81-86	heat shock protein family D (Hsp60) member 1	Homo sapiens	112-117
24816982-11	2014	The localization of NDRG2 overlaps only partially with that of aquaporin 4, the membrane-bound water channel that is concentrated in the astrocytic endfeet.	Water	95-100	aquaporin 4	Homo sapiens	63-74
34795590-3	2021	Method: We prepared hot water extracts of CP (CPE) and quantified the amount of total polyphenol and flavonoid using HPLC analysis.	Water	24-29	carboxypeptidase E	Homo sapiens	42-44
24659576-5	2014	RESULTS: In settings with network malfunction, consumers of tap water versus POU-treated water had increased GII [incidence density ratio (IDR) = 1.34; 95% CI: 1.00, 1.79].	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
24659576-6	2014	The subset of nonblinded studies showed a significant association between GII and tap water versus POU-treated water consumption (IDR = 1.52; 95% CI: 1.05, 2.20), but there was no association based on studies that blinded participants to their POU water treatment status (IDR = 0.98; 95% CI: 0.90, 1.08).	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
24659576-8	2014	CONCLUSIONS: Tap water consumption is associated with GII in malfunctioning distribution networks.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
34795590-3	2021	Method: We prepared hot water extracts of CP (CPE) and quantified the amount of total polyphenol and flavonoid using HPLC analysis.	Water	24-29	carboxypeptidase E	Homo sapiens	46-49
34805111-5	2021	The resulted DA-PLMA-PMAA could self-assemble in water to form pH-dependent polymeric micelles with a diameter of ~65 nm and PDI as low as 0.105.	Water	49-54	peptidyl arginine deiminase 1	Homo sapiens	125-128
24047516-8	2014	Age &lt;5 years and consumption of tap water were risk factors for norovirus infection.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
25079986-0	2014	Quantitative method to determine the regional drinking water odorant regulation goals based on odor sensitivity distribution: illustrated using 2-MIB.	Water	55-60	MIB E3 ubiquitin protein ligase 1	Homo sapiens	146-149
34118005-7	2021	The wheat bran-HA composite has a potential application for Se(IV) removal in water treatment.	Water	78-83	squalene epoxidase	Homo sapiens	60-66
24817439-0	2014	Fluorescence sensors for selective detection of Hg2+ ion using a water-soluble poly(vinyl alcohol) bearing rhodamine B moieties.	Water	65-70	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	48-51
34454984-7	2021	D(t) and tau of water diffusing along and perpendicular to vessels/tracheids main axes together with relaxation times and an were quantified.	Water	16-21	microtubule associated protein tau	Homo sapiens	9-12
34596809-0	2021	Recombinant water stress protein 1 (Re-WSP1) suppresses colon cancer cell growth through the miR-539/beta-catenin signaling pathway.	Water	12-17	catenin beta 1	Homo sapiens	101-113
24983378-0	2014	Alum and squalene-oil-in-water emulsion enhance the titer and avidity of anti-Abeta antibodies induced by multimeric protein antigen (1-11)E2, preserving the Igg1-skewed isotype distribution.	Water	25-30	LOC105243590	Mus musculus	158-162
24970260-3	2014	METHODS: Hepc KO mice were given DFP in drinking water from age 6 to 18 months.	Water	49-54	hepcidin antimicrobial peptide	Mus musculus	9-13
34810312-11	2021	The material exhibited superior regenerative properties for Cu2+, Co2+ and Cd2+ ions from water for up to three cycles.	Water	90-95	CD2 molecule	Homo sapiens	75-78
24943941-0	2014	The parched planet: water on tap.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	29-32
34716519-1	2022	In this study, chitosan/sodium alginate/nano cellulose (CSA-N) nanocomposite hydrogels were prepared using a completely green route and used as sorbents to adsorb Cd2+ ions from water and soil systems of an environmental aspect.	Water	178-183	CD2 molecule	Homo sapiens	163-166
24943954-7	2014	Here we show, by studying the liquid-liquid transition in the ST2 model of water with the use of six advanced sampling methods to compute the free-energy surface, that two metastable liquid phases and a stable crystal phase exist at the same deeply supercooled thermodynamic condition, and that the transition between the two liquids satisfies the thermodynamic criteria of a first-order transition.	Water	75-80	ST2	Homo sapiens	62-65
24943954-10	2014	These findings provide unambiguous evidence for a liquid-liquid transition in the ST2 model of water, and point to the separation of time scales between crystallization and relaxation as being crucial for enabling it.	Water	95-100	ST2	Homo sapiens	82-85
34714942-2	2022	A ~200-fold decrease in fluorescence quantum yield of m-NMe2 -LpHBDI in alcohols (e.g., MeOH, EtOH, and 2-PrOH) supports this GFP-derived compound as a fluorescence turn-on water sensor, with large fluorescence intensity differences between H2 O and ROH emissions in various H2 O/ROH binary mixtures.	Water	173-178	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	56-60
24747567-1	2014	Aquaporin-5 (AQP5) is a water-selective channel protein that is expressed in submucosal glands and alveolar epithelial cells in the lungs.	Water	24-29	aquaporin 5	Mus musculus	0-11
24747567-1	2014	Aquaporin-5 (AQP5) is a water-selective channel protein that is expressed in submucosal glands and alveolar epithelial cells in the lungs.	Water	24-29	aquaporin 5	Mus musculus	13-17
34828864-0	2021	Nutritional and Chemical-Physical Characterization of Fresh Pasta Gnocchi Prepared with Sea Water as New Active Ingredient.	Water	92-97	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	88-91
24684853-0	2014	Cardiovascular and metabolic responses to tap water ingestion in young humans: does the water temperature matter?	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
34828864-1	2021	This study shows the chemical-physical and nutritional results obtained using food-grade sea water for the preparation of fresh pasta Gnocchi with respect to those prepared with tap water.	Water	93-98	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	89-92
34828864-4	2021	The analysis of chlorides showed that the samples prepared with sea water had a significantly lower NaCl content after cooking in comparison with those prepared with tap water.	Water	68-73	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	64-67
24508576-0	2014	Using the reversible inhibition of gastric lipase by Orlistat for investigating simultaneously lipase adsorption and substrate hydrolysis at the lipid-water interface.	Water	151-156	lipase F, gastric type	Canis lupus familiaris	35-49
34778619-5	2021	High-temperature treatments with water (500  C; 1-2% H2O in Ar) are shown to form either Pd metal or PdO particles, with Pd-Beta being more susceptible to these effects than Pd-CHA.	Water	33-38	transcription factor like 5	Homo sapiens	177-180
24508576-8	2014	Based on a kinetic model describing the inhibition by Orlistat and the activity of DGL on a mixed 1,2-dicaprin/Orlistat monolayer spread at the air-water interface combined with surface pressure measurements, it was possible to monitor DGL adsorption at the lipid-water interface and substrate hydrolysis in the course of a single experiment.	Water	148-153	lipase F, gastric type	Canis lupus familiaris	83-86
24508576-8	2014	Based on a kinetic model describing the inhibition by Orlistat and the activity of DGL on a mixed 1,2-dicaprin/Orlistat monolayer spread at the air-water interface combined with surface pressure measurements, it was possible to monitor DGL adsorption at the lipid-water interface and substrate hydrolysis in the course of a single experiment.	Water	264-269	lipase F, gastric type	Canis lupus familiaris	83-86
24508576-8	2014	Based on a kinetic model describing the inhibition by Orlistat and the activity of DGL on a mixed 1,2-dicaprin/Orlistat monolayer spread at the air-water interface combined with surface pressure measurements, it was possible to monitor DGL adsorption at the lipid-water interface and substrate hydrolysis in the course of a single experiment.	Water	264-269	lipase F, gastric type	Canis lupus familiaris	236-239
34687554-4	2021	During the past decade, stress has been given to extract fresh, clean and safe potable elixir of life from the bountiful stores of sea water by exploiting various technologies.	Water	135-140	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	131-134
24164509-8	2014	Fluoride concentration in tap water was low (0.04+-SD 0.02 ppm), but was higher in bottled water (0.28+-SD 0.40 ppm).	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
24636953-10	2014	In tap water only trace amounts of antidepressants including citalopram (up to 1.5ng/l), mianserin (up to 0.9ng/l), sertraline (&lt;3.1ng/l), moclobemid (up to 0.3ng/l) and venlafaxine (up to 1.9ng/l) were detected.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
34350652-1	2021	A series of novel osmaindenes 1 - 6 bearing different substituents (CF 3 , H, I, Br, OCH 3 , N(Ph) 2 ) has been synthesized by nucleophilic reaction of water with the corresponding aromatic osmanaphthalyne complexes.	Water	152-157	neurexophilin 2	Homo sapiens	93-100
24138387-10	2014	Distilled water, 1% NaOCl, ethanol and EDTA were associated with significantly more remaining TAP.	Water	10-15	nuclear RNA export factor 1	Homo sapiens	94-97
34722969-3	2021	The presence of Na3(IrF6) H2O monohydrate is predicted.	Water	26-29	interferon regulatory factor 6	Homo sapiens	20-24
24597927-0	2014	A new approach for evaluating the water resistance of sunscreens on consumers: tap water vs. salt water vs. chlorine water.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	79-82
24597927-0	2014	A new approach for evaluating the water resistance of sunscreens on consumers: tap water vs. salt water vs. chlorine water.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
24597927-9	2014	The method proved capable of discriminating not only sunscreen performances with different water proofing ingredients but also water specific sunscreens such as a beach dedicated product showing a 20% higher resistance to salt water vs. tap and chlorine waters.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	237-240
24597927-9	2014	The method proved capable of discriminating not only sunscreen performances with different water proofing ingredients but also water specific sunscreens such as a beach dedicated product showing a 20% higher resistance to salt water vs. tap and chlorine waters.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	237-240
25856896-6	2014	The coverage rates of tap water and harmless toilets were 10.14% and 10.21% in 1997, and 100.0% and 90.38% in 2012, respectively.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
34680700-5	2021	AQP is an integral membrane channel protein that aids in the rapid flux of water and other small solutes that move across the lipid membrane.	Water	75-80	aquaporin AQPAe.a	Diaphorina citri	0-3
24390474-3	2014	The aquaporin-4 (AQP4) water channel plays a critical role in water homeostasis and migration of astrocytes in the central nervous system, probably offering a new therapeutic target for protecting against upper motor neuron degeneration after SCI.	Water	23-28	aquaporin 4	Mus musculus	4-15
24390474-3	2014	The aquaporin-4 (AQP4) water channel plays a critical role in water homeostasis and migration of astrocytes in the central nervous system, probably offering a new therapeutic target for protecting against upper motor neuron degeneration after SCI.	Water	23-28	aquaporin 4	Mus musculus	17-21
34225022-0	2021	Molecular dynamics study of water transport through AQP5-R188C mutant causing palmoplantar keratoderma (PPK) using the gating mechanism concept.	Water	28-33	aquaporin 5	Homo sapiens	52-56
24390474-3	2014	The aquaporin-4 (AQP4) water channel plays a critical role in water homeostasis and migration of astrocytes in the central nervous system, probably offering a new therapeutic target for protecting against upper motor neuron degeneration after SCI.	Water	62-67	aquaporin 4	Mus musculus	4-15
24390474-3	2014	The aquaporin-4 (AQP4) water channel plays a critical role in water homeostasis and migration of astrocytes in the central nervous system, probably offering a new therapeutic target for protecting against upper motor neuron degeneration after SCI.	Water	62-67	aquaporin 4	Mus musculus	17-21
25350771-10	2014	Addition of SH3 domain ligand (such as PRD peptides), as well as addition of the water-soluble PI(4,5)P2 analogue, can both enhance the MC-S&amp;G ability of BIN1 on membranes without PI(4,5)P2, indicating that the key to activate BIN1 is to disrupt the exon10-SH3 interaction.	Water	81-86	bridging integrator 1	Homo sapiens	158-162
34333423-5	2021	The comparison of two different solvent systems showed that the derivatives had better alpha-glucosidase inhibitory activity in the DMSO system than that of in ethanol-water system.	Water	168-173	sucrase-isomaltase	Homo sapiens	87-104
25231107-1	2014	Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface.	Water	38-43	aquaporin 4	Homo sapiens	0-11
25231107-1	2014	Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface.	Water	38-43	aquaporin 4	Homo sapiens	13-17
25231107-2	2014	AQP4 serves as a water entry site during brain edema formation, and regulation of AQP4 may therefore be of therapeutic interest.	Water	17-22	aquaporin 4	Homo sapiens	0-4
24787756-2	2014	In this paper we investigate such an effective interaction of like-charged ions in water by using the 3D-RISM-SCF method (i.e., electronic structure theory combined with three-dimensional integral equation theory for molecular solvents).	Water	83-88	KIT ligand	Homo sapiens	110-113
25231107-8	2014	The unit water permeability was determined for the mutant AQP4s upon heterologous expression in Xenopus laevis oocytes (along with serine-to-aspartate mutants of the same residues to mimic a phosphorylation).	Water	9-14	aquaporin 4 L homeolog	Xenopus laevis	58-62
34139227-7	2021	Log Kd and log soil organic carbon-water distribution coefficient (Koc) both increase with increasing carbon chain length of PFASs.	Water	35-40	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	67-70
25231107-10	2014	Thus phosphorylation of six different serine residues in the COOH terminus of AQP4 appears not to be required for proper plasma membrane localization of AQP4 or to act as a molecular switch to gate the water channel.	Water	202-207	aquaporin 4	Homo sapiens	78-82
24668807-3	2014	BCO1 has been thought to be a monooxygenase, incorporating oxygen from O2 and H2O into its cleavage products.	Water	78-81	beta-carotene oxygenase 1	Homo sapiens	0-4
25317482-1	2014	A novel noncentrosymmetric calcium borate, Ca2[B5O9] (OH) H2O (1), was synthesized under solvothermal condition using mixed solvents of pyridine and H2O.	Water	58-61	carbonic anhydrase 2	Homo sapiens	43-46
34331360-2	2021	The water channel protein Aquaporin 5 (AQP5) is involved in the tumorigenesis and progression of various cancers.	Water	4-9	aquaporin 5	Homo sapiens	26-37
25262084-7	2014	The meta-SMR with 95% CI of liver cancer for the highest versus lowest category of iAs exposure level in drinking water was 1.80 (1.61 to 2.02).	Water	114-119	LY6/PLAUR domain containing 4	Homo sapiens	9-12
25462676-5	2014	We measured urine TCAA and creatinine, and 9 haloacetic acids and 4 trihalomethanes (THM) in tap water.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
25462676-9	2014	Mean total tap water consumption was 2.2l/48h (standard error, 0.1l/48h).	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
25462676-10	2014	Geometric mean urine TCAA excretion rate was 17.3pmol/min [95%CI: 14.0-21.3], which increased 2% for a 10% increase in TCAA ingestion and decreased with total tap water consumption (-17%/l), water intake outside home (-32%), plasmatic volume (-64%/l), in smokers (-79%), and in users of non-steroidal anti-inflammatory drugs (-50%).	Water	163-168	nuclear RNA export factor 1	Homo sapiens	159-162
25764804-3	2014	However, the maximum concentration of viable bacteria in the tap water was 700CFU/mL, which exceeds the legal standard for purity of tap water (100CFU/mL).	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
25764804-3	2014	However, the maximum concentration of viable bacteria in the tap water was 700CFU/mL, which exceeds the legal standard for purity of tap water (100CFU/mL).	Water	137-142	nuclear RNA export factor 1	Homo sapiens	61-64
25764804-3	2014	However, the maximum concentration of viable bacteria in the tap water was 700CFU/mL, which exceeds the legal standard for purity of tap water (100CFU/mL).	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
25764804-4	2014	Furthermore, Y. enterocolitica O8 was isolated from the tap water with the use of immunomagnetic beads prepared with anti-Y.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
25764804-7	2014	An epidemiological investigation revealed improper management of the residual chlorine concentration in the tap water.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
25764804-8	2014	This is the first report of an outbreak of Y. enterocolitica due to tap water from a small-scale water system in Japan.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
25518375-1	2014	Neuromyelitis optica (NMO) is autoimmune disease targeting against water channel aquaporin 4 (AQP4), mainly located at astrocyte foot processes in the central nervous system (CNS).	Water	67-72	aquaporin 4	Homo sapiens	94-98
25518390-2	2014	The pathogenic mechanism was found to be distinct from multiple sclerosis since the discovery of the disease specific autoantibody against water channel aquaporin-4.	Water	139-144	aquaporin 4	Homo sapiens	153-164
25514075-4	2014	RESULTS: Nonfiltered tap water accounted for the primary drinking water source in only 10 percent of the respondents.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
25514075-4	2014	RESULTS: Nonfiltered tap water accounted for the primary drinking water source in only 10 percent of the respondents.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	21-24
25514075-6	2014	Nonfiltered tap water was much more likely to be utilized in cooking (58 percent).	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
25211263-1	2014	Bicyclic dibrominated C15 medium-ring ether hexahydrolaureoxanyne was produced directly from an acyclic model C15-epoxide when treated with NBS with water as the solvent.	Water	149-154	placenta associated 8	Homo sapiens	22-25
25211263-1	2014	Bicyclic dibrominated C15 medium-ring ether hexahydrolaureoxanyne was produced directly from an acyclic model C15-epoxide when treated with NBS with water as the solvent.	Water	149-154	placenta associated 8	Homo sapiens	110-113
27379319-2	2014	Its physiopathology is connected with the aquaporin-4 water channel, since antibodies against aquaporin-4 have been found in the cerebrospinal fluid and blood of neuromyelitis optica patients.	Water	54-59	aquaporin 4	Homo sapiens	42-53
27379319-2	2014	Its physiopathology is connected with the aquaporin-4 water channel, since antibodies against aquaporin-4 have been found in the cerebrospinal fluid and blood of neuromyelitis optica patients.	Water	54-59	aquaporin 4	Homo sapiens	94-105
25247736-5	2014	We have determined that these symptoms were caused by the tap water used for irrigation.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
25037389-1	2014	A new water-soluble polysaccharide (SEP-2), with a molecular weight of 6.78 x 10(5)Da, was isolated from Strongylocentrotus nudus eggs under the extraction conditions optimized by response surface methodology (RSM).	Water	6-11	apolipoprotein A-I	Mus musculus	36-41
27840658-1	2014	Aquaporin-4 (AQP4) is a water channel protein that is most highly, but not exclusively, expressed in the central nervous system.	Water	24-29	aquaporin 4	Homo sapiens	0-11
27840658-1	2014	Aquaporin-4 (AQP4) is a water channel protein that is most highly, but not exclusively, expressed in the central nervous system.	Water	24-29	aquaporin 4	Homo sapiens	13-17
24927198-10	2014	The adjusted incidence rate ratios (IRRs) per 1-mug/L increment in arsenic levels in drinking water were as follows: IRR = 1.03 (95% CI: 1.01, 1.06) and IRR = 1.02 (95% CI: 0.99, 1.05) for all and strict diabetes cases, respectively.	Water	94-99	insulin receptor related receptor	Homo sapiens	36-39
24927198-10	2014	The adjusted incidence rate ratios (IRRs) per 1-mug/L increment in arsenic levels in drinking water were as follows: IRR = 1.03 (95% CI: 1.01, 1.06) and IRR = 1.02 (95% CI: 0.99, 1.05) for all and strict diabetes cases, respectively.	Water	94-99	insulin receptor related receptor	Homo sapiens	117-120
25249806-6	2014	CONCLUSION: Early epidemiological studies demonstrated significant associations between high groundwater nitrate levels and elevated methemoglobin levels in infants fed drinking water-diluted formulas.	Water	99-104	hemoglobin subunit gamma 2	Homo sapiens	133-146
25000576-6	2014	Tap water consumption was significantly associated with creatinine-adjusted urinary TCAA concentration (beta = 0.23 mug/g creatinine per log10 unit; 95% CI: 0.12, 0.35).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
25000576-11	2014	Our results suggest that tap water consumption, water source, smoking, age, and household income as the primary determinants of exposure to drinking water DBPs should be considered in exposure assessment.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
24926622-7	2014	Furthermore, study on 190 E. coli isolates from water samples, using EPA Method 1603 followed by bacterial identification with Biolog MicroStation  and ycjPCR assay, indicated that the prevalence of ycjM in the E. coli water isolates had a significant (p &lt; 0.05, odds ratio ) spatial variation from 69.6% to 93.8%.	Water	48-53	glucosylglycerate phosphorylase	Escherichia coli str. K-12 substr. MG1655	199-203
24926622-7	2014	Furthermore, study on 190 E. coli isolates from water samples, using EPA Method 1603 followed by bacterial identification with Biolog MicroStation  and ycjPCR assay, indicated that the prevalence of ycjM in the E. coli water isolates had a significant (p &lt; 0.05, odds ratio ) spatial variation from 69.6% to 93.8%.	Water	219-224	glucosylglycerate phosphorylase	Escherichia coli str. K-12 substr. MG1655	199-203
25127652-7	2014	The practical applications of 1-AgNPs for selective sensing of NO(2-) in different water samples such as ground, river, pond and tap water have also been demonstrated.	Water	133-138	nuclear RNA export factor 1	Homo sapiens	129-132
25184686-9	2014	The possibility is discussed that AQP5 is synthesized during pregnancy as a stable protein that functions to regulate water secretion during lactation.	Water	118-123	aquaporin 5	Rattus norvegicus	34-38
24802807-4	2014	Yfh1 also offers the unique advantage that its cold denaturation can be observed above the freezing point of water, thus allowing the facile construction of the whole protein stability curve and hence the measurement of accurate thermodynamic parameters for unfolding.	Water	109-114	ferroxidase	Saccharomyces cerevisiae S288C	0-4
24648513-4	2014	Substitution of Rheb Gly-63 with alanine impaired both intrinsic and TSC2 GTPase-activating protein (GAP)-mediated GTP hydrolysis by displacing the hydrolytic water molecule, whereas introduction of a bulkier valine side chain selectively blocked GTP binding by steric occlusion of the gamma-phosphate.	Water	159-164	TSC complex subunit 2	Homo sapiens	69-73
24440420-4	2014	PEG-PAA(SH)-PDEA was water-soluble at acidic and physiological pH but formed robust and monodisperse polymersomes with an average size of ~35nm upon increasing the pH to 7.8 or above followed by oxidative crosslinking.	Water	21-26	phosphodiesterase 6A	Homo sapiens	12-16
24666204-3	2014	These autoantibodies were later shown to target aquaporin-4 (AQP4), the most abundant water channel in the central nervous system (CNS).	Water	86-91	aquaporin 4	Homo sapiens	61-65
25194123-5	2014	In 2012, tap water provided to almost one million Italians in 112 municipalities of three regions (Latium, Tuscany and Campania), did not comply with the legal limits for the following parameters: arsenic, boron and fluorides.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
24712643-5	2014	The interaction energy results show that TDO"s solubility in water is originated from the TDO-water cyclic oligomer.	Water	61-66	tryptophan 2,3-dioxygenase	Homo sapiens	41-44
24712643-5	2014	The interaction energy results show that TDO"s solubility in water is originated from the TDO-water cyclic oligomer.	Water	61-66	tryptophan 2,3-dioxygenase	Homo sapiens	90-93
24712643-5	2014	The interaction energy results show that TDO"s solubility in water is originated from the TDO-water cyclic oligomer.	Water	94-99	tryptophan 2,3-dioxygenase	Homo sapiens	41-44
24712643-5	2014	The interaction energy results show that TDO"s solubility in water is originated from the TDO-water cyclic oligomer.	Water	94-99	tryptophan 2,3-dioxygenase	Homo sapiens	90-93
24684841-1	2014	A water soluble beta-1,3-glucan schizophyllan (SPG) can be recognized by an immunocyte receptor called dectin-1.	Water	2-7	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	16-24
24556505-5	2014	Oil-in-water emulsions (GLA-emulsion, Ribi, Emulsigen) resulted in partial aggregation and loss of structural integrity of the gp140 trimer.	Water	7-12	galactosidase alpha	Homo sapiens	24-27
24722189-5	2014	Interestingly, when the subjects were immersed in water for the same time as that used in the CA-1 session (CA-17), the CA led to a hypothermic type of acclimation.	Water	50-55	carbonic anhydrase 1	Homo sapiens	94-98
26580383-7	2014	We further found that the presence of a hydrophobic staple in the peptide-MDM2 interface tends to trap a network of water molecules prior to binding.	Water	116-121	MDM2 proto-oncogene	Homo sapiens	74-78
24633562-7	2014	Tap water and bottled water were also analyzed by the column, and nitrate was detected as 20.1 and 13.8 mg L(-1), respectively.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
24882978-9	2014	A substantial reduction was observed in the lesional mRNA levels of IL-17A and IL-23 in the mineral water group.	Water	100-105	interleukin 17A	Mus musculus	68-74
24531323-1	2014	Hepatic antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) of Nile tilapia in response to pesticide methomyl and recovery pattern were researched by exposing tilapia to sub-lethal methomyl concentrations of 0, 0.2, 2, 20 and 200 mug/L for 30 days, and then transferred to methomyl-free water for 18 days.	Water	301-306	catalase	Oreochromis niloticus	69-72
23800619-1	2014	This paper reports the first recreation-related leptospirosis outbreak in Sri Lanka in 20 office workers who were involved in white-water rafting during a staff outing.	Water	132-137	sorcin	Homo sapiens	74-77
24581998-9	2014	Post hoc tests showed that the CCT in the sodium chloride (NaCl) 10.0% and tap-water groups increased significantly less than with 4 other preservation methods.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
24581998-12	2014	Lens epithelial cells from eyes preserved in tap water for 48 hours appeared to be intact but lost cell organization.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
24581998-13	2014	CONCLUSIONS: Of the 15 tested methods to preserve porcine eyes, tap water (mineral content 1.79 mmol/L) resulted in the least corneal swelling.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
24374967-4	2014	Administration of HMGB1 antagonists inhibited severity of EAU significantly via mechanisms that include inhibition of IRBP-specific T cell proliferation and their IFN-gamma and IL-17 production.	Water	58-61	retinol binding protein 3, interstitial	Mus musculus	118-122
24532542-0	2014	Determination of endosulfan isomers and their metabolites in tap water and commercial samples using microextraction by packed sorbent and GC-MS. A simple, rapid, accurate and sensitive method using microextraction by packed sorbent (MEPS) followed by GC-MS has been pursued for the determination of organochlorine insecticide endosulfan isomers (alpha and beta) and their metabolites (ether, lactone and sulfate).	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
24532542-8	2014	The developed method is applicable for the quantification of these compounds in tap water and commercial samples.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
24655108-5	2014	Moreover, the contact angle of water on the PIL emulsion film (emulsifier-free emulsion polymerization) was found to be ~70  (static measurement), indicating that the surface of the PIL film was relatively hydrophobic.	Water	31-36	serpin family A member 2 (gene/pseudogene)	Homo sapiens	44-47
24655108-5	2014	Moreover, the contact angle of water on the PIL emulsion film (emulsifier-free emulsion polymerization) was found to be ~70  (static measurement), indicating that the surface of the PIL film was relatively hydrophobic.	Water	31-36	serpin family A member 2 (gene/pseudogene)	Homo sapiens	182-185
24655108-7	2014	However, when water was dropped on the PIL film just after the water already on the surface had completely retreated, the PIL film was instantaneously hydrophobic again.	Water	14-19	serpin family A member 2 (gene/pseudogene)	Homo sapiens	39-42
24655108-7	2014	However, when water was dropped on the PIL film just after the water already on the surface had completely retreated, the PIL film was instantaneously hydrophobic again.	Water	14-19	serpin family A member 2 (gene/pseudogene)	Homo sapiens	122-125
24655108-7	2014	However, when water was dropped on the PIL film just after the water already on the surface had completely retreated, the PIL film was instantaneously hydrophobic again.	Water	63-68	serpin family A member 2 (gene/pseudogene)	Homo sapiens	39-42
24655108-7	2014	However, when water was dropped on the PIL film just after the water already on the surface had completely retreated, the PIL film was instantaneously hydrophobic again.	Water	63-68	serpin family A member 2 (gene/pseudogene)	Homo sapiens	122-125
24655108-8	2014	This result suggests that responsiveness of the PIL emulsion film was switchable between hydrophobic (in air) and hydrophilic (in water).	Water	130-135	serpin family A member 2 (gene/pseudogene)	Homo sapiens	48-51
25044065-2	2014	The C F   H O interactions between suitably fluorinated nucleophiles and the hydrogen-bond network at the phase boundary of oil droplets enable the formation of a unique microstructure to facilitate on water catalyst-free reactions, which are difficult to realize using nonfluorinated substrates.	Water	202-207	complement factor H	Homo sapiens	4-11
34331360-2	2021	The water channel protein Aquaporin 5 (AQP5) is involved in the tumorigenesis and progression of various cancers.	Water	4-9	aquaporin 5	Homo sapiens	39-43
24571080-1	2014	Aquaporin-4 (AQP4) and glutamate transporter-1 (GLT-1) represent the major water and glutamate astrocyte buffering gateways in the brain.	Water	75-80	aquaporin 4	Homo sapiens	0-11
24571080-1	2014	Aquaporin-4 (AQP4) and glutamate transporter-1 (GLT-1) represent the major water and glutamate astrocyte buffering gateways in the brain.	Water	75-80	aquaporin 4	Homo sapiens	13-17
24398001-4	2014	The GAB model was most accurate for all temperatures and all levels of water activity, followed by the BET and Halsey models.	Water	71-76	alpha-1-B glycoprotein	Homo sapiens	4-7
24571080-4	2014	AQP4/GLT-1 colocalization showed higher coefficients for the perilesional cortices compared with controls, suggesting an increased water/glutamate-buffering capability.	Water	131-136	aquaporin 4	Homo sapiens	0-4
34717456-8	2021	The effect of temporal variability of the water column during noise-averaging time on EGF retrieval is discussed and quantified.	Water	42-47	epidermal growth factor	Homo sapiens	86-89
24632216-5	2014	The presence of pure water, sucrose penta-hydrate, and sucrose dihydrate was confirmed by using theoretical calculations based on the hybrid B3LYP/6-31G(*) method and the experimental vibrational spectra.	Water	21-26	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	143-146
24133043-3	2014	The PULA-alt/ran-PEG polyurethanes exhibited low T(g) (-47.3 ~ -34.4 C), wide mechanical properties (stress sigma(t): 4.6-32.6 MPa, modulus E: 11.4-323.9 MPa and strain epsilon: 468-1530%) and low water contact angle (35.4-51.4 ).	Water	197-202	RAN, member RAS oncogene family	Rattus norvegicus	13-16
34143507-1	2021	Nocturnal stomatal conductance (gsn ) represents a significant source of water-loss, with implications for metabolism, thermal regulation and water-use efficiency.	Water	142-147	gelsolin	Homo sapiens	32-35
24601645-2	2014	For this purpose, we first compare several electrostatic representations of TBP with regards to its polarity and conformational properties, its interactions with H2O, HNO3, and UO2(NO3)2 species, its relative free energies of solvation in water or oil environments, the properties of the pure TBP liquid and of the pure-TBP/water interface.	Water	162-165	TATA-box binding protein	Homo sapiens	76-79
24601645-2	2014	For this purpose, we first compare several electrostatic representations of TBP with regards to its polarity and conformational properties, its interactions with H2O, HNO3, and UO2(NO3)2 species, its relative free energies of solvation in water or oil environments, the properties of the pure TBP liquid and of the pure-TBP/water interface.	Water	239-244	TATA-box binding protein	Homo sapiens	76-79
24492152-7	2014	The experimental results show that COD, DO and the concentration of fecal coliform vary a little with the changing of water temperature; TBC increases dramatically when the water temperature is over 16  C; and TBC in summer is 30 times more than that in winter.	Water	118-123	TBC1 domain family member 1	Homo sapiens	137-140
24492152-7	2014	The experimental results show that COD, DO and the concentration of fecal coliform vary a little with the changing of water temperature; TBC increases dramatically when the water temperature is over 16  C; and TBC in summer is 30 times more than that in winter.	Water	118-123	TBC1 domain family member 1	Homo sapiens	210-213
24155180-7	2014	Moreover, the method was applied successfully to the determination of chromium(III) in synthetic samples and tap water.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
34585441-8	2022	Overexpression of SNHG8 improved the neural function defect, reduced brain water content, BBB permeability, brain tissue damage and inflammation, and inhibited microglia activation.	Water	75-80	small integral membrane protein 4	Rattus norvegicus	18-23
24492152-7	2014	The experimental results show that COD, DO and the concentration of fecal coliform vary a little with the changing of water temperature; TBC increases dramatically when the water temperature is over 16  C; and TBC in summer is 30 times more than that in winter.	Water	173-178	TBC1 domain family member 1	Homo sapiens	137-140
24492152-7	2014	The experimental results show that COD, DO and the concentration of fecal coliform vary a little with the changing of water temperature; TBC increases dramatically when the water temperature is over 16  C; and TBC in summer is 30 times more than that in winter.	Water	173-178	TBC1 domain family member 1	Homo sapiens	210-213
24632573-12	2014	In this school we showed a significant association between the number of water containers delivered each week and absenteeism (IRR = 0.98 95%CI 0.96-1.00).	Water	73-78	insulin receptor related receptor	Homo sapiens	127-130
34518855-1	2021	Atomistic molecular dynamics simulations are used to predict 1H NMR T1 relaxation of water from paramagnetic Gd3+ ions in solution at 25  C. Simulations of the T1 relaxivity dispersion function r1 computed from the Gd3+-1H dipole-dipole autocorrelation function agree within  8% of measurements in the range f0   5   500 MHz, without any adjustable parameters in the interpretation of the simulations, and without any relaxation models.	Water	85-90	GRDX	Homo sapiens	109-112
24534568-1	2014	A pipette tip-based molecularly imprinted polymer monolith microextraction (PT-MIPMME) method was developed for the selective extraction of difenoconazole in tap water and grape juice.	Water	162-167	nuclear RNA export factor 1	Homo sapiens	158-161
24534568-8	2014	The results showed that difenoconazole was selectively enriched from tap water and grape juice samples.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
24893328-1	2014	To clarify the mechanism of high-mobility group box (HMGB) 1-induced brain edema formation, this study focused on the effect of HMGB1 on aquaporin (AQP) 4, a water channel, in rat brain.	Water	158-163	high mobility group box 1	Rattus norvegicus	128-133
34698175-5	2021	Respecta  Hydragel demonstrated efficacy in regulating the water flux by inducing AQP3 expression thus determining a positive water balance within the vaginal epithelium.	Water	59-64	aquaporin 3 (Gill blood group)	Homo sapiens	82-86
24859195-0	2014	Characterization of biofilm and corrosion of cast iron pipes in drinking water distribution system with UV/Cl2 disinfection.	Water	73-78	endogenous retrovirus group W member 5	Homo sapiens	107-110
24859195-2	2014	Passivation occurred more rapidly in the AR with UV/Cl2 than in the one with Cl2 alone, decreasing iron release for higher corrosivity of water.	Water	138-143	endogenous retrovirus group W member 5	Homo sapiens	52-55
24859195-2	2014	Passivation occurred more rapidly in the AR with UV/Cl2 than in the one with Cl2 alone, decreasing iron release for higher corrosivity of water.	Water	138-143	endogenous retrovirus group W member 5	Homo sapiens	77-80
24783149-2	2014	The main objective of introduction of bottled water in the society was its better safety, taste and convenience over tap water.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	117-120
24636435-0	2014	Compliance with tap water iontophoresis in patients with palmoplantar hyperhidrosis.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
34698175-5	2021	Respecta  Hydragel demonstrated efficacy in regulating the water flux by inducing AQP3 expression thus determining a positive water balance within the vaginal epithelium.	Water	126-131	aquaporin 3 (Gill blood group)	Homo sapiens	82-86
24636435-1	2014	BACKGROUND: Patients tend to be noncompliant with tap water iontophoresis (TWI), which is an effective treatment option for palmoplantar hyperhidrosis.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
25206304-6	2014	Water contact analysis revealed that nHA could improve the hydrophilic nature of the COL/PCL/nHA-SBF scaffold.	Water	0-5	PHD finger protein 1	Homo sapiens	89-92
34698081-3	2021	Two peptides, namely WTIAVPGPPHS from myomesin (water-soluble fraction, A = 0.9091) and FKRPPL from troponin (salt-soluble fraction, A = 0.8333), were selected as the most promising inhibitors of DPP-IV.	Water	48-53	dipeptidyl peptidase 4	Homo sapiens	196-202
24993024-0	2014	Substitution of a hydroxamic acid anchor into the MK-2 dye for enhanced photovoltaic performance and water stability in a DSSC.	Water	101-106	MAPK activated protein kinase 2	Homo sapiens	50-54
24993024-1	2014	An efficient synthetic protocol to functionalize the cyanoacrylic acid anchoring group of commercially available MK-2 dye with a highly water-stable hydroxamate anchoring group is described.	Water	136-141	MAPK activated protein kinase 2	Homo sapiens	113-117
24993024-4	2014	The hydroxamate anchoring group also contributes to significantly increased water stability, with a decrease in the rate constant for dye desorption of MK-2HA relative to MK-2 in the presence of water by as much as 37.5%.	Water	76-81	MAPK activated protein kinase 2	Homo sapiens	152-156
24370694-1	2014	Hourly mass concentrations of water-soluble ions in PM1 and gasses (NH3, HNO3, HCl) were on-line measured with a Monitor for AeRosols and Gases Analyzer (MARGA) in Shanghai from Oct. 1 to Nov. 16, 2012.	Water	30-35	transmembrane protein 11	Homo sapiens	52-55
24370694-4	2014	The average mass concentration of PM1 and total water-soluble ions (TWSI) in PM1 in haze episodes were 78.9 +- 29.9 mug/m(3) and 47.2 +- 17.2 mug/m(3), 3.11 times (from 1.49 to 4.06 times) and 3.28 times (1.96 to 4.34 times) as those in non-haze periods, respectively.	Water	48-53	transmembrane protein 11	Homo sapiens	77-80
24993024-4	2014	The hydroxamate anchoring group also contributes to significantly increased water stability, with a decrease in the rate constant for dye desorption of MK-2HA relative to MK-2 in the presence of water by as much as 37.5%.	Water	195-200	MAPK activated protein kinase 2	Homo sapiens	152-156
24370694-17	2014	In addition, Strong NH3 and HNO3 reaction resulted in the enhancement of NH4NO3 mass fraction, therefore increased associated water content in PM1 under high RH condition and contributed to visibility degradation.	Water	126-131	transmembrane protein 11	Homo sapiens	143-146
34584907-3	2021	Our results showed that 1 h exposure to water avoidance stress (WAS) for 7 consecutive days decreased histone acetylation at the GR promoter and increased histone acetylation at the CRH promoter in the CeA.	Water	40-45	glutathione-disulfide reductase	Rattus norvegicus	129-131
24586644-7	2014	Notch inhibition in mice immunized with IRBP with a gamma-secretase inhibitor (GSI) suppressed EAU progression, even when GSI was administered as late as 13 days after IRBP immunization.	Water	95-98	retinol binding protein 3, interstitial	Mus musculus	40-44
26580058-4	2014	The algorithm is applied to the second hairpin of GB1 in water, in urea, and in guanidine chloride.	Water	57-62	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	50-53
34519748-0	2021	Facile synthesis of Fe-doped CoP nanosheet arrays wrapped by graphene for overall water splitting.	Water	82-87	caspase recruitment domain family member 16	Homo sapiens	29-32
25149788-8	2014	The images of H-fragments from HX on (H2O)N also exhibit a strong central intensity, however, with a different kinetic energy distribution which originates from different processes: the HX acidic dissociation followed by H3O neutral hydronium radical formation after the UV excitation, and the slow H-fragments stem from subsequent decay of the H3O.	Water	38-41	H3 clustered histone 15	Homo sapiens	221-224
25149788-8	2014	The images of H-fragments from HX on (H2O)N also exhibit a strong central intensity, however, with a different kinetic energy distribution which originates from different processes: the HX acidic dissociation followed by H3O neutral hydronium radical formation after the UV excitation, and the slow H-fragments stem from subsequent decay of the H3O.	Water	38-41	H3 clustered histone 15	Homo sapiens	345-348
24447127-0	2014	"Nok": a phytosterol-based amphiphile enabling transition-metal-catalyzed couplings in water at room temperature.	Water	87-92	serine/threonine/tyrosine kinase 1	Homo sapiens	1-4
34521353-8	2021	Depleted SOX2 or PVT1 alleviated brain injury in MCAO rats as reflected by neuronal apoptosis and oxidative stress restriction, brain water content reduction, and neurological deficit and neuron survival improvements.	Water	134-139	SRY-box transcription factor 2	Rattus norvegicus	9-13
24325630-1	2014	In this study, transferrin (Tf)-modified poly(ethylene glycol)-phosphatidylethanolamine (mPEG-PE) micelles loaded with the poorly water-soluble drug, R547 (a potent and selective ATP-competitive cyclin-dependent kinase (CDK) inhibitor), were prepared and evaluated for their targeting efficiency and cytotoxicity in vitro and in vivo to A2780 ovarian carcinoma cells, which overexpress transferrin receptors (TfR).	Water	130-135	transferrin	Mus musculus	15-26
25580212-2	2014	Several mechanistic proposals describe the unique manganese center as a site for water binding and subsequent formation of a high valent Mn-oxo center that reacts with a M-OH unit (M = Mn or CaII) to form the O-O bond.	Water	81-86	carbonic anhydrase 2	Homo sapiens	191-195
28344237-5	2014	Each sample was employed as photoanode and tested in the water splitting reaction by recording I-V curves and comparing the results with commercial P25 powders.	Water	57-62	tubulin polymerization promoting protein	Homo sapiens	148-151
34567012-5	2021	Some archaea produce gas vesicles, which are nanoparticles released by the archaea that increase the buoyancy of the cells and facilitate an upward flotation in water columns.	Water	161-166	gastrin	Homo sapiens	21-24
25070343-1	2014	BACKGROUND: S-allyl mercaptocysteine (SAMC), a water-soluble component derived from garlic, has been found to exert multi-antitumor activities.	Water	47-52	solute carrier family 25 member 26	Homo sapiens	38-42
24246238-10	2014	Urinary metabolites of both atrazine and dealkylated triazine were correlated with tap water consumption (OR=2.94, 1.09-7.90, and OR=1.82, 1.10-3.03, respectively); hydroxylated triazine metabolites were correlated with fish intake (OR=1.48, 1.09-1.99).	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
34359058-6	2021	The fiber sensor was successfully employed to detect As3+in pond water samples, demonstrating that it has the potential for As3+detection with the advantages of low cost, high sensitivity, and a simple structure.	Water	65-70	PDS5 cohesin associated factor B	Homo sapiens	53-56
24329914-6	2014	The current study examined the protein levels of p21 and p53 (which can up-regulate p21) in NOD mice fed with either water or EGCG, and the effect of EGCG on p21 and p53 in cell line models with either normal or defective Rb.	Water	117-122	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	49-52
25047483-4	2014	The primary textures of the SF1 halite typified by cumulate and chevron halite suggest halite deposited in a shallow saline water and halite Th can serve as an temperature proxy.	Water	124-129	splicing factor 1	Homo sapiens	28-31
34359058-6	2021	The fiber sensor was successfully employed to detect As3+in pond water samples, demonstrating that it has the potential for As3+detection with the advantages of low cost, high sensitivity, and a simple structure.	Water	65-70	PDS5 cohesin associated factor B	Homo sapiens	124-127
34134416-6	2021	On the basis of calculated structural/interfacial properties and experimental findings, the 2D Mg(OH)2 in terms of three-layer model was unraveled to substitute toxic Cd2+ ion and sorb radioactive UO22+ that is coordinated by water and hydroxyl groups.	Water	226-231	CD2 molecule	Homo sapiens	167-170
25004402-5	2014	Based on our studies the excellent syn stereochemistry can be explained by chelation control of the acyl hydrazone and the B(OH)(2) moiety.	Water	124-131	synemin	Homo sapiens	35-38
24172223-1	2014	Neuromyelitis optica (NMO) is an autoimmune demyelinating inflammatory disorder, mediated by pathogenic autoantibodies against aquaporin 4 (AQP4), the main water channel of the central nervous system (CNS).	Water	156-161	aquaporin 4	Homo sapiens	127-138
24172223-1	2014	Neuromyelitis optica (NMO) is an autoimmune demyelinating inflammatory disorder, mediated by pathogenic autoantibodies against aquaporin 4 (AQP4), the main water channel of the central nervous system (CNS).	Water	156-161	aquaporin 4	Homo sapiens	140-144
34373707-2	2021	The imbalance of the retinal microenvironment and destruction of the blood-retinal barrier have a significant role in the progression of DR. Inward rectifying potassium channel 4.1 (Kir4.1) is located on Muller cells and is closely related to potassium homeostasis, water balance and glutamate clearance in the whole retina.	Water	266-271	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	182-188
24333849-1	2014	Little is known about the nature of the microbiology in tap waters delivered to consumers via public drinking water distribution systems (DWDSs).	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
25029447-6	2014	However, the removability of radionuclides from contaminated tap water has not been tested to date.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
25029447-7	2014	Thus, the current research was undertaken to assess the capability of the apparatus to remove radionuclides from artificially contaminated tap water.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
25029447-8	2014	The results presented here demonstrate that the apparatus can reduce radioactivity levels to below the detection limit in applied tap water containing either 300 Bq/kg of 137Cs or 150 Bq/kg of 125I.	Water	134-139	nuclear RNA export factor 1	Homo sapiens	130-133
26279537-1	2014	The reaction between the solvated electron and hydronium cation H3O(+) in water constitutes a fundamental reaction in chemistry.	Water	74-79	H3 clustered histone 15	Homo sapiens	64-70
24217856-1	2014	A water-soluble "turn-on" fluorescent probe (RD1) for Fe(3+) based on rhodamine B was designed and synthesized.	Water	2-7	phosphodiesterase 6B	Homo sapiens	45-48
34175710-6	2021	Meanwhile, PM2.5, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1).	Water	32-37	cellular communication network factor 2	Rattus norvegicus	100-131
24055670-4	2014	We assess three types of entities engaged in water management along the source-to-tap spectrum (watershed agencies, water utilities, and public health authorities).	Water	45-50	nuclear RNA export factor 1	Homo sapiens	82-85
34175710-6	2021	Meanwhile, PM2.5, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1).	Water	32-37	cellular communication network factor 2	Rattus norvegicus	133-137
34435473-1	2021	Although several studies have shown that release of water channel proteins, aquaporin 1 (AQP1) and AQP2 in urinary extracellular vesicles (uEV-AQP1 and -AQP2), were altered in experimental kidney injury models, their release in human chronic kidney disease (CKD) has been largely unexplored.	Water	52-57	aquaporin 2	Homo sapiens	153-157
24423251-7	2014	Many of the ASR1-enriched genomic loci we found encode enzymes involved in cell wall synthesis and remodeling as well as channels implicated in water and solute flux, such as aquaporins.	Water	144-149	abscisic stress-ripening protein 1	Solanum lycopersicum	12-16
24893272-0	2014	Water-soluble conjugated polymer as a platform for adenosine deaminase sensing based on fluorescence resonance energy transfer technique.	Water	0-5	adenosine deaminase	Homo sapiens	51-70
24893272-1	2014	We report a new biosensor for adenosine deaminase (ADA) sensing based on water-soluble conjugated poly(9,9-bis(6"-N,N,N-trimethylammonium)hexyl)fluorine phenylene (PFP) and fluorescence resonance energy transfer technique.	Water	73-78	adenosine deaminase	Homo sapiens	30-49
24893272-1	2014	We report a new biosensor for adenosine deaminase (ADA) sensing based on water-soluble conjugated poly(9,9-bis(6"-N,N,N-trimethylammonium)hexyl)fluorine phenylene (PFP) and fluorescence resonance energy transfer technique.	Water	73-78	adenosine deaminase	Homo sapiens	51-54
23988537-1	2014	Using N-acetyl-L-cysteine (NAC) as a stabilizer, well water-dispersed, high-quality and stable CdHgSe quantum dots were facilely synthesized via a simple aqueous phase method.	Water	54-59	X-linked Kx blood group	Homo sapiens	27-30
34074399-6	2021	This method was successfully demonstrated for Cd2+ detection in drinking water and yesso scallop samples.	Water	73-78	CD2 molecule	Homo sapiens	46-49
25061789-8	2014	The hydrophilic BCAm-Ba(2+) complexes distributed in the PNIPAAm-co-BCAm chain prevent the water molecules from leaving the polymer chains, which leads to an increase in the transition temperature and the complicated variation of the transition temperature range, as environmental stimuli-response behavior, with increasing BaCl2 concentrations.	Water	91-96	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	16-20
25061789-8	2014	The hydrophilic BCAm-Ba(2+) complexes distributed in the PNIPAAm-co-BCAm chain prevent the water molecules from leaving the polymer chains, which leads to an increase in the transition temperature and the complicated variation of the transition temperature range, as environmental stimuli-response behavior, with increasing BaCl2 concentrations.	Water	91-96	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	68-72
25842512-2	2014	Most organized crystallographic pattern was shown to observe in a drop of water after treatment Bioptron lamp (content of liquid-crystal associates (LCA)--6.90 +- 0.23), and stored in a silver vessel (content LCA--6.28 +- 0.17), and the least organized, almost amorphous precipitate is formed in a drop of water stored in plastic containers (content LCA--2.92 +- 0.15%).	Water	74-79	RPGR interacting protein 1	Homo sapiens	122-156
25842512-2	2014	Most organized crystallographic pattern was shown to observe in a drop of water after treatment Bioptron lamp (content of liquid-crystal associates (LCA)--6.90 +- 0.23), and stored in a silver vessel (content LCA--6.28 +- 0.17), and the least organized, almost amorphous precipitate is formed in a drop of water stored in plastic containers (content LCA--2.92 +- 0.15%).	Water	74-79	RPGR interacting protein 1	Homo sapiens	209-215
25842512-2	2014	Most organized crystallographic pattern was shown to observe in a drop of water after treatment Bioptron lamp (content of liquid-crystal associates (LCA)--6.90 +- 0.23), and stored in a silver vessel (content LCA--6.28 +- 0.17), and the least organized, almost amorphous precipitate is formed in a drop of water stored in plastic containers (content LCA--2.92 +- 0.15%).	Water	306-311	RPGR interacting protein 1	Homo sapiens	122-156
34246002-8	2021	The UCP process provides a novel strategy for rapid contaminants removal in water treatment via continuous generation of free RMnS.	Water	76-81	uncoupling protein 1	Homo sapiens	4-7
23900955-7	2014	Furthermore, tap water from Lisbon and three small neighbor cities was analyzed.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
34512542-1	2021	The aquaporin 2 (AQP2) plays a critical role in water reabsorption to maintain water homeostasis.	Water	48-53	aquaporin 2	Canis lupus familiaris	4-15
34512542-1	2021	The aquaporin 2 (AQP2) plays a critical role in water reabsorption to maintain water homeostasis.	Water	48-53	aquaporin 2	Canis lupus familiaris	17-21
34512542-1	2021	The aquaporin 2 (AQP2) plays a critical role in water reabsorption to maintain water homeostasis.	Water	79-84	aquaporin 2	Canis lupus familiaris	4-15
34512542-1	2021	The aquaporin 2 (AQP2) plays a critical role in water reabsorption to maintain water homeostasis.	Water	79-84	aquaporin 2	Canis lupus familiaris	17-21
34512542-7	2021	The functional analysis showed that MDCK cells transfected with AQP2-G215S displayed reduced water permeability compared with AQP2-WT.	Water	93-98	aquaporin 2	Canis lupus familiaris	64-68
34512542-7	2021	The functional analysis showed that MDCK cells transfected with AQP2-G215S displayed reduced water permeability compared with AQP2-WT.	Water	93-98	aquaporin 2	Canis lupus familiaris	126-130
34512542-9	2021	Taken together, these findings suggested that AQP2-G215S was misfolded and retained in the ER and could not be translocated to the apical membrane to function as a water channel, which revealed the molecular pathogenic mechanism of AQP2-G215S mutation and explained for the phenotype of NDI in this patient.	Water	164-169	aquaporin 2	Homo sapiens	46-50
34512542-9	2021	Taken together, these findings suggested that AQP2-G215S was misfolded and retained in the ER and could not be translocated to the apical membrane to function as a water channel, which revealed the molecular pathogenic mechanism of AQP2-G215S mutation and explained for the phenotype of NDI in this patient.	Water	164-169	aquaporin 2	Homo sapiens	232-236
34500945-9	2021	Post-curing has also been shown to be beneficial for the cured sample with the application of shielding water.	Water	104-109	solute carrier family 35 member G1	Homo sapiens	0-4
34443261-0	2021	Computational Study of Novel Semiconducting Sc2CT2 (T = F, Cl, Br) MXenes for Visible-Light Photocatalytic Water Splitting.	Water	107-112	chromosome 12 open reading frame 73	Homo sapiens	63-65
34443261-2	2021	In this study, we have comprehensively explored the crystal structures, electronic properties, and optical absorbance of two-dimensional (2D) Sc2CT2 (T = F, Cl, Br) MXenes and their corresponding photocatalytic water splitting, under the visible-light region, by first-principles calculations.	Water	211-216	chromosome 12 open reading frame 73	Homo sapiens	161-163
34443261-4	2021	Creatively, we proposed Sc2CT2 (T = F, Br) as new materials; the band edge alignments of Sc2CF2 can be tuned to meet the water redox potentials at pH = 8.0.	Water	121-126	chromosome 12 open reading frame 73	Homo sapiens	39-41
34286718-6	2021	The specificity of the developed platform was cross-validated against various metallic pollutants and cations commonly found in water bodies (i.e., Cd2+, Pb2+, Cr3+, Fe3+, Mg2+, Ca2+, Zn2+, K+ and Al3+).	Water	128-133	CD2 molecule	Homo sapiens	148-151
34351836-1	2021	However, GST enzymes are most famously known for their roles in catalyzing the conjugation of reduced glutathione (GSH) to electrophilic centers on a wide variety of substrates to induce water-solubility to compounds as a protective antioxidant mechanism against toxic substances.	Water	187-192	glutathione S-transferase kappa 1	Homo sapiens	9-12
34264248-4	2021	Furthermore, the auxiliary can be removed in 96% yield under acidic conditions (0.25% TFA in H2O) that leave glycosidic linkages intact.	Water	93-96	coagulation factor III, tissue factor	Homo sapiens	86-89
34236851-3	2021	This study reports on the reaction of methionine with the active aqua form of cisplatin, cis-(PtCl(NH3)2(H2O))+, isolating the encounter complex of the reactant pair, {cis-(PtCl(NH3)2(H2O))+ Met}, by electrospray ionization.	Water	105-108	SAFB like transcription modulator	Homo sapiens	38-48
34236851-3	2021	This study reports on the reaction of methionine with the active aqua form of cisplatin, cis-(PtCl(NH3)2(H2O))+, isolating the encounter complex of the reactant pair, {cis-(PtCl(NH3)2(H2O))+ Met}, by electrospray ionization.	Water	105-108	SAFB like transcription modulator	Homo sapiens	191-194
34236851-3	2021	This study reports on the reaction of methionine with the active aqua form of cisplatin, cis-(PtCl(NH3)2(H2O))+, isolating the encounter complex of the reactant pair, {cis-(PtCl(NH3)2(H2O))+ Met}, by electrospray ionization.	Water	184-187	SAFB like transcription modulator	Homo sapiens	38-48
34236851-3	2021	This study reports on the reaction of methionine with the active aqua form of cisplatin, cis-(PtCl(NH3)2(H2O))+, isolating the encounter complex of the reactant pair, {cis-(PtCl(NH3)2(H2O))+ Met}, by electrospray ionization.	Water	184-187	SAFB like transcription modulator	Homo sapiens	191-194
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	58-61	SAFB like transcription modulator	Homo sapiens	65-68
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	58-61	SAFB like transcription modulator	Homo sapiens	353-356
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	58-61	SAFB like transcription modulator	Homo sapiens	395-398
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	58-61	SAFB like transcription modulator	Homo sapiens	472-475
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	58-61	SAFB like transcription modulator	Homo sapiens	545-548
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	58-61	SAFB like transcription modulator	Homo sapiens	602-605
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	346-349	SAFB like transcription modulator	Homo sapiens	65-68
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	346-349	SAFB like transcription modulator	Homo sapiens	353-356
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	346-349	SAFB like transcription modulator	Homo sapiens	395-398
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	346-349	SAFB like transcription modulator	Homo sapiens	472-475
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	346-349	SAFB like transcription modulator	Homo sapiens	545-548
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	346-349	SAFB like transcription modulator	Homo sapiens	602-605
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	369-374	SAFB like transcription modulator	Homo sapiens	65-68
34236851-5	2021	To summarize the major findings: (i) the {cis-(PtCl(NH3)2(H2O))+ Met} encounter complex, lying on the reaction coordinate of the Eigen-Wilkins preassociation mechanism for ligand substitution, is delivered in the gas phase and characterized by IR ion spectroscopy; (ii) upon vibrational excitation, ligand exchange occurs within {cis-(PtCl(NH3)2(H2O))+ Met}, releasing water and cis-(PtCl(NH3)2(Met))+, along the calculated energy profile; (iii) activated cis-(PtCl(NH3)2(Met))+ ions undergo NH3 departure, forming a chelate complex, (PtCl(NH3)(Met))+, whose structure is congruent with overwhelming S-Met ligation as the primary coordination step.	Water	369-374	SAFB like transcription modulator	Homo sapiens	353-356
34293862-4	2021	In contrast, phenethylamines with a beta-hydroxy group generate substituted 2-phenylaziridium through ESI in-source CID-induced H2O loss.	Water	128-131	amyloid beta (A4) precursor protein	Mus musculus	34-40
34291315-4	2021	Moreover, we demonstrated herein the development of the indigoidine-based whole-cell biosensors to detect bioavailable Hg(II) and Pb(II) in water samples by employing metal-responsive transcriptional regulator MerR and PbrR as the sensory elements, and the indigoidine biosynthesis gene cluster as a reporter element.	Water	140-145	activator/repressor of mer operon	Escherichia coli	210-214
24727946-2	2014	We genotyped three single-nucleotide polymorphisms in the aquaporin-4 water channel-encoding gene (AQP4), which were previously shown to be associated with (i) SIDS in Norwegian infants (rs2075575), (ii) severe brain edema (rs9951307), and (iii) increased brain water permeability (rs3906956).	Water	70-75	aquaporin 4	Homo sapiens	58-69
34291315-8	2021	Although fairly good linear relationships were obtained in a relatively limited concentration range of the concentrations of heavy metal ions, these findings suggest that genetically controlled indigoidine biosynthesis triggered by the MerR family transcriptional regulator can enable a sensitive, visual, and qualitative whole-cell biosensor for bioindicating the presence of bioaccessible heavy metal in environmental water samples.	Water	420-425	activator/repressor of mer operon	Escherichia coli	236-240
24727946-2	2014	We genotyped three single-nucleotide polymorphisms in the aquaporin-4 water channel-encoding gene (AQP4), which were previously shown to be associated with (i) SIDS in Norwegian infants (rs2075575), (ii) severe brain edema (rs9951307), and (iii) increased brain water permeability (rs3906956).	Water	70-75	aquaporin 4	Homo sapiens	99-103
34149894-7	2021	The water isolated site (WA) and ethyl acetate isolated site (EA) significantly reversed complete Freund"s adjuvant (CFA)-induced changes in the levels of NO, IL-6, TNF-alpha, IgG and IFN-gamma, while the n-butanol isolated site (NB) only reversed the changes in IL-6 and IgG contents.	Water	4-9	interferon gamma	Rattus norvegicus	184-193
25082856-0	2014	Arabidopsis SNAREs SYP61 and SYP121 coordinate the trafficking of plasma membrane aquaporin PIP2;7 to modulate the cell membrane water permeability.	Water	129-134	syntaxin of plants 61	Arabidopsis thaliana	19-24
23632123-3	2014	A 1:1 case-control study showed that consumption of tap water was a risk factor for acquiring infection [odds ratio (OR) 2.18, 95% confidence interval (CI) 1.11-4.28].	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
34664465-6	2021	In the comprehensive human activity intensity map of Lashihai watershed, the highest intensity value of water area was at the mouth of the sea, the lowest intensity value was at the center of the sea, and the overall trend of intensity gradually decreased from the surrounding to the middle.	Water	104-109	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	139-142
24308807-9	2014	Thus, boiling of tap water can be regarded as a "detoxification" process and may reduce human exposure to halogenated DBPs through tap water ingestion.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	131-134
24364736-9	2014	Concentrations of adsorbable organohalogens (AOX) in the gray water effluent increased significantly upon treatment for all electrode combinations tested.	Water	62-67	acyl-CoA oxidase 1	Homo sapiens	45-48
24632126-0	2014	Evaluation of exposure to trihalomethanes in tap water and semen quality: a prospective study in Wuhan, China.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
34328717-6	2021	Mechanical characterization shows that a critical degree of core removal is required to obtain soft disk-like particles at an oil-water interface, which present a distinct response to compression.	Water	130-135	POC1 centriolar protein A	Homo sapiens	95-99
25005864-3	2014	The response ratios for washing by tap water, boiling and sun drying were 0.59, 0.71 and 0.65, respectively, indicating that they could reduce the pesticide residues effectively.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
34393708-9	2021	When we applied higher sonication conditions, the ADC and RD showed enhancement until 48 h, and became comparable to contralateral values at 72 h. AQP-4 expression was upregulated after FUS-induced BBBD in both sonication conditions at 48 h. The results of this study provide preliminary evidence on how mechanical forces from FUS alter water dynamics through diffusion tensor imaging (DTI) measures and AQP4 expression.	Water	337-342	aquaporin 4	Rattus norvegicus	147-152
25030724-0	2014	Radioactive substances in tap water.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
25030724-4	2014	On March 16(th), 2011, radioiodine and radioactive cesium were detected at levels of 177 Bq/kg and 58 Bq/kg, respectively, in tap water in Fukushima city (about 62km northwest of TEPCO F-1 NPP).	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
25030724-5	2014	On March 20th, radioiodine was detected in tap water at a level of 965 Bq/kg, which is over the value-index of restrictions on food and drink intake (radioiodine 300 Bq/kg (infant intake 100 Bq/kg)) designated by the Nuclear Safety Commission.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
24717641-1	2014	Astrocyte water channel aquaporin-4 (AQP4) facilitates water movement across the blood-brain barrier and into injured astrocytes.	Water	10-15	aquaporin 4	Mus musculus	24-35
24717641-1	2014	Astrocyte water channel aquaporin-4 (AQP4) facilitates water movement across the blood-brain barrier and into injured astrocytes.	Water	10-15	aquaporin 4	Mus musculus	37-41
24717641-1	2014	Astrocyte water channel aquaporin-4 (AQP4) facilitates water movement across the blood-brain barrier and into injured astrocytes.	Water	55-60	aquaporin 4	Mus musculus	24-35
24717641-1	2014	Astrocyte water channel aquaporin-4 (AQP4) facilitates water movement across the blood-brain barrier and into injured astrocytes.	Water	55-60	aquaporin 4	Mus musculus	37-41
24717641-7	2014	Brain water content was increased by 2.8+-0.4% in occluded AQP4(+/+) mice, significantly greater than that of 0.3+-0.6% in AQP4(-/-) mice.	Water	6-11	aquaporin 4	Mus musculus	59-63
34213892-2	2021	NKCC1 regulates Cl- homeostasis and cell volume, handling a pivotal role in transepithelial water transport and neuronal excitability.	Water	92-97	solute carrier family 12 member 2	Homo sapiens	0-5
24698721-6	2014	Furthermore, the improvement of BrO3(-) reduction on P25-GR was observed in the treatment of a tap water.	Water	99-104	tubulin polymerization promoting protein	Homo sapiens	53-56
24343032-7	2014	If tap water is used, then the use of sterile filters is strongly recommended.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
24246232-3	2014	In comparison to two species (MS-1 and MS-2) isolated from artificial media and the failure of bacterial colonies formation using water extracts of sediment (10%, w/v), five colony species (WC-1 to WC-5) appeared using concentrated water extracts of sediment that is 10-fold enhancement of nutrient level.	Water	232-237	ATPase copper transporting beta	Homo sapiens	190-202
24917858-5	2014	As proof-of-concept we demonstrate examples of microbial dynamics in (i) flowing tap water from a municipal drinking water supply network and (ii) river water from a small creek subject to two rainfall events.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
34153952-0	2021	Water calorimetry-basedkQfactors for Farmer-type ionization chambers in the SOBP of a carbon-ion beam.	Water	0-5	sine oculis binding protein homolog	Homo sapiens	76-80
24411164-0	2014	The effects of water immersion and restraint stress on the expressions of apelin, apelin receptor (APJR) and apoptosis rate in the rat heart.	Water	15-20	apelin	Rattus norvegicus	74-80
24261925-14	2014	CONCLUSION: Changes in the diffusion of water within the lumbar intervertebral discs at the L1-2, L2-3, and L5-S1 levels appear to be related to differences in within-session pain reports following a single treatment of spinal manipulative therapy.	Water	40-45	immunoglobulin kappa variable 1D-43	Homo sapiens	98-102
34153952-4	2021	To this end, the absorbed dose to water in the12C-SOBP is measured using the water calorimeter developed at Physikalisch-Technische Bundesanstalt (PTB), allowing a direct calibration of the ionization chambers used (PTW TM30013 and IBA FC65G) and thereby an experimental determination of the chamber-specifickQfactors.	Water	34-39	sine oculis binding protein homolog	Homo sapiens	50-54
25047806-6	2014	These findings suggest that the water-soluble components of cigarette smoke may cause BSM hyperresponsiveness via an increase in MLCK and RhoA.	Water	32-37	ras homolog family member A	Rattus norvegicus	138-142
24411164-0	2014	The effects of water immersion and restraint stress on the expressions of apelin, apelin receptor (APJR) and apoptosis rate in the rat heart.	Water	15-20	apelin receptor	Rattus norvegicus	82-97
24411164-3	2014	We aimed to investigate whether water immersion and restraint stress have effects on apelin and APJR expression and apoptosis in heart tissue of male Wistar rats.	Water	32-37	apelin	Rattus norvegicus	85-91
34226538-1	2021	Gas-liquid flows occur in many natural environments such as breaking waves, river rapids and human-made systems, including nuclear reactors and water treatment or conveyance infrastructure.	Water	144-149	gastrin	Homo sapiens	0-3
24684853-3	2014	METHODS: We determined, in a randomized crossover study, the acute cardiovascular and metabolic responses to 500 mL of tap water at 3  C (cold), 22  C (room) and 37  C (body) in 12 young humans to ascertain an effect of water temperature.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
34128581-0	2021	PEG-Induced Controllable Thin-Thickness Gradient and Water Retention: A Simple Way to Programme Deformation of Hydrogel Actuators.	Water	53-58	progestagen associated endometrial protein	Homo sapiens	0-3
24091560-3	2014	Tap water has the same washing effects as saline.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
24091560-9	2014	There were statistically significant differences in QoL scores between tap water nasal irrigation group and non-tap water nasal irrigation group.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
24091560-10	2014	The tap water nasal irrigation group had better QoL scores than the non-tap water nasal irrigation group.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
34128581-5	2021	The thickness gradient and water retention can be controllably adjusted by changing PEG concentration.	Water	27-32	progestagen associated endometrial protein	Homo sapiens	84-87
34117841-6	2021	The obtained Cr-CoP-NR/CC catalyst shows the potential to replace the costly Pt-based HER catalysts in the water electrolyzer.	Water	107-112	caspase recruitment domain family member 16	Homo sapiens	16-19
34927988-0	2021	Hierarchically Assembling CoFe Prussian Blue Analogue Nanocubes on CoP Nanosheets as Highly Efficient Electrocatalysts for Overall Water Splitting.	Water	131-136	caspase recruitment domain family member 16	Homo sapiens	67-70
24916350-9	2014	The subcellular colocalization of Kir4.1 and AQP4 in epithelial supporting cells indicates functional coupling of potassium and water flow in the cochlea.	Water	128-133	aquaporin 4	Homo sapiens	45-49
34126011-5	2021	Although the lengthening methylene chain in the polymers weakened the hydrogen generation ability of Pp-x@g-C3N4, the conjugated double bonds, solubilization, and dispersion of Pp-x polycationic surfactants made Pp-x@g-C3N4 superior to g-C3N4 in water splitting.	Water	246-251	protein phosphatase 4 catalytic subunit	Homo sapiens	101-105
24595904-2	2014	The results suggested that the incorporation of m-MS into PCL-PEG-PCL could significantly improve the water adsorption of the m-MS/PCL-PEG-PCL composite (m-MPC) scaffolds.	Water	102-107	PHD finger protein 1	Homo sapiens	58-61
34126011-5	2021	Although the lengthening methylene chain in the polymers weakened the hydrogen generation ability of Pp-x@g-C3N4, the conjugated double bonds, solubilization, and dispersion of Pp-x polycationic surfactants made Pp-x@g-C3N4 superior to g-C3N4 in water splitting.	Water	246-251	protein phosphatase 4 catalytic subunit	Homo sapiens	177-181
24595904-2	2014	The results suggested that the incorporation of m-MS into PCL-PEG-PCL could significantly improve the water adsorption of the m-MS/PCL-PEG-PCL composite (m-MPC) scaffolds.	Water	102-107	PHD finger protein 1	Homo sapiens	66-69
34126011-5	2021	Although the lengthening methylene chain in the polymers weakened the hydrogen generation ability of Pp-x@g-C3N4, the conjugated double bonds, solubilization, and dispersion of Pp-x polycationic surfactants made Pp-x@g-C3N4 superior to g-C3N4 in water splitting.	Water	246-251	protein phosphatase 4 catalytic subunit	Homo sapiens	212-216
24595904-2	2014	The results suggested that the incorporation of m-MS into PCL-PEG-PCL could significantly improve the water adsorption of the m-MS/PCL-PEG-PCL composite (m-MPC) scaffolds.	Water	102-107	PHD finger protein 1	Homo sapiens	66-69
24595904-2	2014	The results suggested that the incorporation of m-MS into PCL-PEG-PCL could significantly improve the water adsorption of the m-MS/PCL-PEG-PCL composite (m-MPC) scaffolds.	Water	102-107	PHD finger protein 1	Homo sapiens	66-69
34262475-11	2021	Tty, mTb and serum irisin levels increased after hot water immersion.	Water	53-58	fibronectin type III domain containing 5	Homo sapiens	19-25
24875554-0	2014	Levels of haloacetic acids in tap water in an urban Australian city and its relevance to autosomal dominant polycystic kidney disease.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
34200257-1	2021	Water content is an important factor in lipase-catalyzed reactions in organic media but is frequently ignored in the study of lipases by molecular dynamics (MD) simulation.	Water	0-5	PAN0_003d1715	Moesziomyces antarcticus	40-46
34200257-4	2021	The position of water molecules aggregated on the protein surface in MAOS media is the major determinant of the unique conformations of lipases and particularly impacts the distribution of hydrophilic and hydrophobic amino acids on the lipase surface.	Water	16-21	PAN0_003d1715	Moesziomyces antarcticus	236-242
24886757-2	2014	This study reports the perspectives on health risks from tap water and corresponding use of, and spending on, bottled water in a number of different communities in Canada.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
34200257-5	2021	Additionally, two maxima were observed in the water-lipase radial distribution function in MAOS systems, implying the formation of two water shells around lipase in these systems.	Water	46-51	PAN0_003d1715	Moesziomyces antarcticus	52-58
34200257-5	2021	Additionally, two maxima were observed in the water-lipase radial distribution function in MAOS systems, implying the formation of two water shells around lipase in these systems.	Water	46-51	PAN0_003d1715	Moesziomyces antarcticus	155-161
34200257-5	2021	Additionally, two maxima were observed in the water-lipase radial distribution function in MAOS systems, implying the formation of two water shells around lipase in these systems.	Water	135-140	PAN0_003d1715	Moesziomyces antarcticus	52-58
34200257-5	2021	Additionally, two maxima were observed in the water-lipase radial distribution function in MAOS systems, implying the formation of two water shells around lipase in these systems.	Water	135-140	PAN0_003d1715	Moesziomyces antarcticus	155-161
24708966-4	2014	LEP-2b ointment significantly accelerated the decrustation of the wounded skin, shortened the healing time and increased the water and hydroxyproline contents of the healed skin.	Water	125-130	late cornified envelope 1B	Homo sapiens	0-5
34154083-2	2021	Many parameters contribute to the spectral signature of an oil layer on the sea surface: the optical properties of the water column and of the oil, the film thickness, the surface roughness, the atmospheric radiance reaching the surface (direct and diffuse components), the geometry of observation and illumination.	Water	119-124	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
24712483-1	2014	Aquaporin 4 (AQP4) is the main water channel in the central nervous system (CNS) and specifically localized to astrocyte processes.	Water	31-36	aquaporin 4	Homo sapiens	0-11
24712483-1	2014	Aquaporin 4 (AQP4) is the main water channel in the central nervous system (CNS) and specifically localized to astrocyte processes.	Water	31-36	aquaporin 4	Homo sapiens	13-17
24712483-2	2014	Recent studies indicate that AQP4 regulates various biological functions of astrocytes, including maintaining CNS water balance, spatial buffering of extracellular potassium, calcium signal transduction, regulation of neurotransmission, synaptic plasticity, and adult neurogenesis, while under neuropathological conditions, AQP4 has a role in astrogliosis and proinflammatory cytokine secretion.	Water	114-119	aquaporin 4	Homo sapiens	29-33
34200211-3	2021	Adsorption performances of the hydrogel toward Pb2+, Cu2+ and Cd2+ in water under different condition as well as multi-ion competitive sorption were investigated.	Water	70-75	CD2 molecule	Homo sapiens	62-65
34120413-1	2021	Aquaporin-2 (AQP2) is a homotetrameric water channel responsible for the final water reuptake in the kidney.	Water	39-44	aquaporin 2	Homo sapiens	0-11
24424055-4	2014	Expression of EDN1 and one of its receptors, EDNRAa, was stimulated in zebrafish acclimated to acidic water.	Water	102-107	endothelin receptor type Aa	Danio rerio	45-51
34120413-1	2021	Aquaporin-2 (AQP2) is a homotetrameric water channel responsible for the final water reuptake in the kidney.	Water	39-44	aquaporin 2	Homo sapiens	13-17
34120413-1	2021	Aquaporin-2 (AQP2) is a homotetrameric water channel responsible for the final water reuptake in the kidney.	Water	79-84	aquaporin 2	Homo sapiens	0-11
24734643-5	2014	It can be explained that the water activated by the ceramics has a higher concentration of H+, which decreases the potential difference across the cell membrane to release the apoptosis inducing factor (AIF).	Water	29-34	apoptosis inducing factor mitochondria associated 1	Homo sapiens	176-201
34120413-1	2021	Aquaporin-2 (AQP2) is a homotetrameric water channel responsible for the final water reuptake in the kidney.	Water	79-84	aquaporin 2	Homo sapiens	13-17
24734643-5	2014	It can be explained that the water activated by the ceramics has a higher concentration of H+, which decreases the potential difference across the cell membrane to release the apoptosis inducing factor (AIF).	Water	29-34	apoptosis inducing factor mitochondria associated 1	Homo sapiens	203-206
34120413-2	2021	Disease-causing AQP2 mutations induce nephrogenic diabetes insipidus (NDI), a condition that challenges the bodily water balance by producing large urinary volumes.	Water	115-120	aquaporin 2	Homo sapiens	16-20
24650226-4	2014	It was observed that P1 and P2 displayed different temperature dependent solution properties in water, with P1 forming micelles above the LCST of the PNIPA while P2 showing macroscopic phase separation under similar conditions.	Water	96-101	crystallin gamma F, pseudogene	Homo sapiens	21-30
24654998-6	2014	The mass of the adsorbed mucin layers, including the adsorbed mucin and water trapped in the layer, was found to be significantly higher for PSGL-1/mIgG2b than for BSM.	Water	72-77	immunoglobulin heavy constant gamma 2B	Mus musculus	148-154
24654998-6	2014	The mass of the adsorbed mucin layers, including the adsorbed mucin and water trapped in the layer, was found to be significantly higher for PSGL-1/mIgG2b than for BSM.	Water	72-77	mucin-19	Bos taurus	164-167
24192214-8	2014	The latter observation suggests that after ovulation AQP5 is involved in the transcellular movement of water in the oviduct ampulla and oocytes in rats.	Water	103-108	aquaporin 5	Rattus norvegicus	53-57
24699741-2	2014	X-ray crystallographic analyses of FPPS with N-BPs have revealed that N-BPs bind to FPPS with three magnesium ions and several water molecules.	Water	127-132	farnesyl diphosphate synthase	Homo sapiens	35-39
24699741-2	2014	X-ray crystallographic analyses of FPPS with N-BPs have revealed that N-BPs bind to FPPS with three magnesium ions and several water molecules.	Water	127-132	farnesyl diphosphate synthase	Homo sapiens	84-88
24170038-2	2014	We compared changes in pharyngeal swallowing and sensory aspects induced by a carbonated beverage preferred by Japanese with those induced by carbonated water, a sports drink, and tap water in healthy young subjects and elderly inpatients with no swallowing problems.	Water	184-189	nuclear RNA export factor 1	Homo sapiens	180-183
25079411-8	2014	The results of the back trajectory analysis imply that the high concentrations of PM1.0 and its water-soluble inorganic ions may be caused by stagnant weather conditions in Wuhan.	Water	96-101	transmembrane protein 11	Homo sapiens	82-85
24588749-2	2014	Scanning electron microscopy studies indicated that flocs of the PDEA-PS particles were adsorbed at the surface of these water droplets, leading to stable spherical liquid marbles.	Water	121-126	phosphodiesterase 6A	Homo sapiens	65-69
24588749-5	2014	The liquid marbles can be transformed into polymeric capsules containing water by exposure to solvent vapor: the PDEA-PS particles were plasticized with the solvent vapor to form a polymer film at the air-water interface of the liquid marbles.	Water	73-78	phosphodiesterase 6A	Homo sapiens	113-117
24588749-5	2014	The liquid marbles can be transformed into polymeric capsules containing water by exposure to solvent vapor: the PDEA-PS particles were plasticized with the solvent vapor to form a polymer film at the air-water interface of the liquid marbles.	Water	205-210	phosphodiesterase 6A	Homo sapiens	113-117
24601645-3	2014	The free energies of transfer of TBP, UO2(NO3)2, UO2(2+), and the UO2(NO3)2(TBP)2 complex across the water/oil interface are then investigated by potential of mean force (PMF) calculations, comparing different TBP models and two charge models of uranyl nitrate.	Water	101-106	TATA-box binding protein	Homo sapiens	76-79
24601645-3	2014	The free energies of transfer of TBP, UO2(NO3)2, UO2(2+), and the UO2(NO3)2(TBP)2 complex across the water/oil interface are then investigated by potential of mean force (PMF) calculations, comparing different TBP models and two charge models of uranyl nitrate.	Water	101-106	TATA-box binding protein	Homo sapiens	76-79
24512498-7	2014	The mixing and gradient formation units were incorporated into a device for analysis of nitrate in tap water with standard addition as a single run and multiple depth detection cells to provide an extended linear range.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
24628177-0	2014	Two-state thermodynamics of the ST2 model for supercooled water.	Water	58-63	ST2	Homo sapiens	32-35
24628177-1	2014	Thermodynamic properties of the ST2 model for supercooled liquid water exhibit anomalies similar to those observed in real water.	Water	65-70	ST2	Homo sapiens	32-35
24628177-1	2014	Thermodynamic properties of the ST2 model for supercooled liquid water exhibit anomalies similar to those observed in real water.	Water	123-128	ST2	Homo sapiens	32-35
24628177-4	2014	In this work, we reproduce the anomalies of two versions of the ST2 model with an equation of state describing water as a non-ideal "mixture" of two different types of local molecular order.	Water	111-116	ST2	Homo sapiens	64-67
24628177-5	2014	We show that the liquid-liquid transition in the ST2 water is energy-driven.	Water	53-58	ST2	Homo sapiens	49-52
24401990-1	2014	Zebrafish Na(+)/H(+) exchanger 3b (zNHE3b) is highly expressed in the apical membrane of ionocytes where Na(+) is absorbed from ion-poor fresh water against a concentration gradient.	Water	143-148	solute carrier family 9 member A3, tandem duplicate 2	Danio rerio	35-41
24401990-11	2014	These results provide thermodynamic evidence that zNHE3b mediates Na(+) absorption from ion-poor fresh water by its Na(+)/H(+) and Na(+)/NH4(+) exchange activities.	Water	103-108	solute carrier family 9 member A3, tandem duplicate 2	Danio rerio	50-56
24471737-5	2014	Soluble epoxide hydrolase was inhibited using cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid (c-AUCB; 3 mg/L drinking water) for 20 weeks after 5/6 NX.	Water	132-137	epoxide hydrolase 2	Rattus norvegicus	0-25
24309492-6	2014	Then HIFalpha was induced by CoCl2 in drinking water (2 mM, 10 days) after which we compared intrarenal isotonic saline or phenol injection on MAP and RVR in CoCl2 preconditioned and control rats.	Water	47-52	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	5-13
24821666-2	2014	The BSM matrix is exploited to host hydrophobic extended conjugated pi-systems and to prevent undesirable aggregation and render such materials water soluble.	Water	144-149	mucin-19	Bos taurus	4-7
24413272-9	2014	Use of tap water to rinse contact lens cases was associated with significantly more cases contaminated with Gram-negative bacteria (GNB) (30% vs. 10%, p &lt; 0.001), a greater risk of GNB case contamination (OR: 2.91, p &lt; 0.001.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
24586302-1	2014	Identifying which factors influence household water management can help policy makers target interventions to improve drinking water quality for communities that may not receive adequate water quality at the tap.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	208-211
24586302-5	2014	Specifically, households in PRASA communities are more likely to boil and filter their tap water due to perceptions of low water quality.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
24586302-7	2014	Based on informal discussions with community members, we suggest that water quality may be improved if PRASA systems improve the taste and odor of tap water, possibly by allowing for dechlorination prior to distribution, and if non-PRASA systems reduce the turbidity of water at the tap, possibly by increasing the degree of chlorination and filtering prior to distribution.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	147-150
24586302-7	2014	Based on informal discussions with community members, we suggest that water quality may be improved if PRASA systems improve the taste and odor of tap water, possibly by allowing for dechlorination prior to distribution, and if non-PRASA systems reduce the turbidity of water at the tap, possibly by increasing the degree of chlorination and filtering prior to distribution.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	283-286
24586302-7	2014	Based on informal discussions with community members, we suggest that water quality may be improved if PRASA systems improve the taste and odor of tap water, possibly by allowing for dechlorination prior to distribution, and if non-PRASA systems reduce the turbidity of water at the tap, possibly by increasing the degree of chlorination and filtering prior to distribution.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
24586302-7	2014	Based on informal discussions with community members, we suggest that water quality may be improved if PRASA systems improve the taste and odor of tap water, possibly by allowing for dechlorination prior to distribution, and if non-PRASA systems reduce the turbidity of water at the tap, possibly by increasing the degree of chlorination and filtering prior to distribution.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
24361961-3	2014	Aquaporin 4 (AQP4) is a commonly distributed water channel in astrocytes of the CNS, and its expression is decreased in NMO lesions due to astrocyte cytotoxicity.	Water	45-50	aquaporin 4	Homo sapiens	0-11
24361961-3	2014	Aquaporin 4 (AQP4) is a commonly distributed water channel in astrocytes of the CNS, and its expression is decreased in NMO lesions due to astrocyte cytotoxicity.	Water	45-50	aquaporin 4	Homo sapiens	13-17
24515349-1	2014	The astrocyte water channel aquaporin-4 (AQP4) is expressed as heterotetramers of M1 and M23 isoforms in which the presence of M23-AQP4 promotes formation of large macromolecular aggregates termed orthogonal arrays.	Water	14-19	aquaporin 4	Homo sapiens	28-39
24515349-1	2014	The astrocyte water channel aquaporin-4 (AQP4) is expressed as heterotetramers of M1 and M23 isoforms in which the presence of M23-AQP4 promotes formation of large macromolecular aggregates termed orthogonal arrays.	Water	14-19	aquaporin 4	Homo sapiens	41-45
24515349-1	2014	The astrocyte water channel aquaporin-4 (AQP4) is expressed as heterotetramers of M1 and M23 isoforms in which the presence of M23-AQP4 promotes formation of large macromolecular aggregates termed orthogonal arrays.	Water	14-19	aquaporin 4	Homo sapiens	131-135
24342098-5	2014	The highest concentration in water was determined in 2010 in a Guadalquivir River STP (perfluorohexanoate, PFHxA: 5.60mugL(-1)) and, in 2011, in an Ebro River STP (perfluorobutane sulfonate, L-PFBS: 0.31mugL(-1)).	Water	29-34	thyroid hormone receptor interactor 10	Homo sapiens	82-85
24342098-5	2014	The highest concentration in water was determined in 2010 in a Guadalquivir River STP (perfluorohexanoate, PFHxA: 5.60mugL(-1)) and, in 2011, in an Ebro River STP (perfluorobutane sulfonate, L-PFBS: 0.31mugL(-1)).	Water	29-34	thyroid hormone receptor interactor 10	Homo sapiens	159-162
32261282-4	2014	Mag-VPCmn quaternized with a shorter alkyl chain (m = 1, 2, 4 and 6) were water dispersible, but that quaternized with a longer alkyl chain (m = 8) was precipitated in water.	Water	74-79	myelin associated glycoprotein	Homo sapiens	0-3
32261282-4	2014	Mag-VPCmn quaternized with a shorter alkyl chain (m = 1, 2, 4 and 6) were water dispersible, but that quaternized with a longer alkyl chain (m = 8) was precipitated in water.	Water	168-173	myelin associated glycoprotein	Homo sapiens	0-3
32261282-5	2014	The surface of water dispersible Mag-VPCmns was positively charged in pH ranging from 2 to 11, and is stable for more than one month in this pH range.	Water	15-20	myelin associated glycoprotein	Homo sapiens	33-36
24443959-3	2014	Here, we utilize measurements of electronic density of states (DOS), using scanning tunneling microscopy/spectroscopy (STM/STS), to identify energy levels responsible for photocatalytic reduction of CO2-water in an artificial photosynthetic process.	Water	203-208	sulfotransferase family 1A member 3	Homo sapiens	119-122
23919619-11	2014	Thus, the Ero1alpha/GPx7/PDI triad generates two disulfide bonds and two H2O molecules at the expense of a single O2 molecule.	Water	73-76	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	10-19
24389345-4	2014	In renal medulla, water deprivation induced alterations in the expression of miR-466(a/b/c/e/p)-3p in a pattern similar to that of miR-200b-3p, a known regulator of osmoresponsive transcription factor Nfat5.	Water	18-23	microRNA 466	Mus musculus	77-84
24389345-4	2014	In renal medulla, water deprivation induced alterations in the expression of miR-466(a/b/c/e/p)-3p in a pattern similar to that of miR-200b-3p, a known regulator of osmoresponsive transcription factor Nfat5.	Water	18-23	nuclear factor of activated T cells 5	Mus musculus	201-206
23166116-0	2014	Pseudofungal tap water contaminants in sputum cytology.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
24186965-1	2014	Aquaporin-4 (AQP4), the principal water channel in astrocytes, is involved in brain water movement, inflammation, and neuroexcitation.	Water	34-39	aquaporin 4	Mus musculus	0-11
24186965-1	2014	Aquaporin-4 (AQP4), the principal water channel in astrocytes, is involved in brain water movement, inflammation, and neuroexcitation.	Water	34-39	aquaporin 4	Mus musculus	13-17
24186965-5	2014	Intracranial pressure elevation and brain water accumulation were much reduced in the AQP4(-/-) vs. AQP4(+/+) mice after carotid artery occlusion, as were blood-brain barrier (BBB) disruption and neuronal loss.	Water	42-47	aquaporin 4	Mus musculus	86-90
24186965-7	2014	Our findings suggest that the neuroprotective effect of AQP4 deletion in global cerebral ischemia involves reduced astrocyte swelling and brain water accumulation, resulting in reduced BBB disruption, inflammation, and neuron death.	Water	144-149	aquaporin 4	Mus musculus	56-60
23098620-0	2014	The relationship of perceptions of tap water safety with intake of sugar-sweetened beverages and plain water among US adults.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
23098620-1	2014	OBJECTIVE: Research is limited on whether mistrust of tap water discourages plain water intake and leads to a greater intake of sugar-sweetened beverages (SSB).	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
23098620-1	2014	OBJECTIVE: Research is limited on whether mistrust of tap water discourages plain water intake and leads to a greater intake of sugar-sweetened beverages (SSB).	Water	82-87	nuclear RNA export factor 1	Homo sapiens	54-57
23098620-3	2014	DESIGN: The study examined perceptions of tap water safety and their cross-sectional association with intake of SSB and plain water.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
23098620-8	2014	Both mistrust of tap water safety and favouring bottled water differed by region, age, race/ethnicity, income and education.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
23098620-9	2014	The associations of tap water mistrust with intake of SSB and plain water were modified by race/ethnicity (P &lt; 0 05).	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
23098620-9	2014	The associations of tap water mistrust with intake of SSB and plain water were modified by race/ethnicity (P &lt; 0 05).	Water	68-73	nuclear RNA export factor 1	Homo sapiens	20-23
23098620-10	2014	Non-white racial/ethnic groups who disagreed that their local tap water was safe to drink were more likely to report low intake of plain water.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
23098620-10	2014	Non-white racial/ethnic groups who disagreed that their local tap water was safe to drink were more likely to report low intake of plain water.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	62-65
23098620-11	2014	The odds of consuming &gt;=1 SSB/d among Hispanics who mistrusted their local tap water was twice that of Hispanics who did not (OR = 2 0; 95 % CI 1 2, 3 3).	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
23098620-12	2014	CONCLUSIONS: Public health efforts to promote healthy beverages should recognize the potential impact of tap water perceptions on water and SSB intake among minority populations.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	105-108
23098620-12	2014	CONCLUSIONS: Public health efforts to promote healthy beverages should recognize the potential impact of tap water perceptions on water and SSB intake among minority populations.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	105-108
23892027-1	2014	The aim of this study was to infer about the modes and extent of dispersion of Sphingomonadaceae via tap water.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
23892027-4	2014	Sphingomonadaceae from hospital tap water comprised members of the genera Sphingomonas, Sphingobium, Novosphingobium and Blastomonas.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
23892027-8	2014	Although the potential of Sphingomonadaceae as opportunistic pathogens may be low, the capacity of these bacteria to thrive in water supply systems, combined with the intrinsic or acquired antibiotic resistance, may raise the risk associated with their occurrence in hospital tap water.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	276-279
23892027-8	2014	Although the potential of Sphingomonadaceae as opportunistic pathogens may be low, the capacity of these bacteria to thrive in water supply systems, combined with the intrinsic or acquired antibiotic resistance, may raise the risk associated with their occurrence in hospital tap water.	Water	280-285	nuclear RNA export factor 1	Homo sapiens	276-279
25147843-2	2014	After conducting a homogeneous, highly saline, clayey, and coastal soil from the Bohai Gulf in northern China in a column experiment, the results show that the depth of the wetting front increased as the water amount applied increased, low-salinity and low-SAR enlarged after irrigation and water redistribution, and the soil pH increased with an increase in irrigation amount.	Water	204-209	sarcosine dehydrogenase	Homo sapiens	257-260
25295305-0	2014	Determination of haloacetic acids in bottled and tap water sources by dispersive liquid-liquid microextraction and GC-MS analysis.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
24185489-0	2013	Rapid and ratiometric detection of hypochlorite with real application in tap water: molecules to low cost devices (TLC sticks).	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
24185489-2	2013	The sensor could be useful for the detection of hypochlorites in tap water.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
24369991-2	2013	Previously, we reported that a water-soluble extract from a culture medium of Ganoderma lucidum mycelia (MAK) exerts antioxidative and cerebroprotective effects against ischemia-reperfusion injury in vivo.	Water	31-36	male germ cell-associated kinase	Rattus norvegicus	105-108
24245794-0	2013	BDE-209: kinetic studies and effect of humic substances on photodegradation in water.	Water	79-84	homeobox D13	Homo sapiens	0-3
24245794-1	2013	BDE-209 is a brominated flame retardant and a priority contaminant, which has been found in several environmental matrices, namely, in water.	Water	135-140	homeobox D13	Homo sapiens	0-3
24245794-3	2013	In this work, the kinetics of BDE-209 photodegradation in water was studied and the influence of different fractions of aquatic humic substances (HS) was evaluated.	Water	58-63	homeobox D13	Homo sapiens	30-33
23945598-4	2013	A high value of the number of waters of crystallization, x, of PB-1 was caused by a lot of defect sites (vacant sites) of [Fe(II)(CN)6](4-) moieties that were filled with coordination and crystallization water molecules.	Water	30-35	polybromo 1	Homo sapiens	63-67
24077429-4	2013	Here, we report the fabrication of SnO2 quantum dots (QDs) with sizes less than the exciton Bohr radius by a facile "top-down" strategy based on laser fragmentation of SnO in water.	Water	175-180	strawberry notch homolog 2	Homo sapiens	35-38
24141712-4	2013	METHODS: Colitis was induced by adding dextran sulfate sodium to the drinking water of GPR43 knockout (-/-) and wild-type mice.	Water	78-83	free fatty acid receptor 2	Mus musculus	87-92
24094221-4	2013	Results show that the mechanical properties of horns have negative correlation with water contents and depend on sampling position and orientation.	Water	84-89	HORNS	Bos taurus	47-52
23684954-1	2013	Aquaporin-4 (AQP4) is the major water channel expressed in the central nervous system (CNS) and is primarily expressed in glial cells.	Water	32-37	aquaporin 4	Mus musculus	0-11
23684954-1	2013	Aquaporin-4 (AQP4) is the major water channel expressed in the central nervous system (CNS) and is primarily expressed in glial cells.	Water	32-37	aquaporin 4	Mus musculus	13-17
23973312-2	2013	Besides its important role in water transport across the blood-brain barrier, our present study demonstrated that AQP4 deficiency impaired hippocampal long-term potentiation (LTP) and hippocampus-dependent memory formation, accompanied by the increase in extracellular glutamate concentration and N-methyl-d-aspartate (NMDA) receptor-mediated currents in hippocampal dentate gyrus (DG) region.	Water	30-35	aquaporin 4	Mus musculus	114-118
24219509-1	2013	Molecular dynamics simulations were performed to investigate water extraction into a solution of 30 vol % tri-n-butylphosphate (TBP) in n-dodecane.	Water	61-66	TATA-box binding protein	Homo sapiens	128-131
24219509-2	2013	Our computational results indicate that the TBP electric dipole moment has a significant effect on the predicted water solubility.	Water	113-118	TATA-box binding protein	Homo sapiens	44-47
24219509-6	2013	By varying the atomic partial charges of the TBP molecules to reproduce a dipole moment close to the experimentally measured value, we were able to predict water solubility in close agreement with experimental measurements.	Water	156-161	TATA-box binding protein	Homo sapiens	45-48
24166980-1	2013	H2 , O2 to H2 O2 : The direct synthesis of hydrogen peroxide from hydrogen and oxygen in water has been made possible by using an iridium(III) complex, [Ir(III) (Cp*)(4-(1H-pyrazol-1-yl-kappaN(2) )benzoic acid-kappaC(3) )(H2 O)]2 SO4 , and flavin mononucleotide.	Water	89-94	relaxin 2	Homo sapiens	0-16
23831225-5	2013	The data provide detailed information on the CNPase reaction mechanism, including substrate binding mode and coordination of the nucleophilic water molecule.	Water	142-147	2',3'-cyclic nucleotide 3' phosphodiesterase	Mus musculus	45-51
24320281-13	2013	We find that while the radial distribution functions (RDFs) of LDA are similar to those observed in experiments, considerable differences exist between the HDA RDFs of ST2 water and experiment.	Water	172-177	ST2	Homo sapiens	168-171
24219567-8	2013	Plain water, from tap or bottled sources, contributed 30-37% of total dietary water.	Water	6-11	nuclear RNA export factor 1	Homo sapiens	18-21
24219567-9	2013	Overall, 56% of drinking water volume was from tap water while bottled water provided 44%.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	47-50
24219567-12	2013	Plain water consumption (bottled and tap) tended to be associated with higher incomes.	Water	6-11	nuclear RNA export factor 1	Homo sapiens	37-40
24186965-8	2014	AQP4 water transport inhibition may improve survival and neurological outcome after cardiac arrest and in other conditions associated with global cerebral ischemia.	Water	5-10	aquaporin 4	Mus musculus	0-4
32480655-0	2014	Changes in timing of water uptake and phenology favours yield gain in terminal water stressed chickpea AtDREB1A transgenics.	Water	21-26	dehydration response element B1A	Arabidopsis thaliana	103-111
32480655-10	2014	The results suggest that DREB1A, a transcription factor involved in the regulation of several genes of abiotic stress response cascade, influenced the pattern of water uptake and flowering across the crop cycle, leading to reduction in the percentage of flower and pod abortion in the glasshouse trials.	Water	162-167	dehydration response element B1A	Arabidopsis thaliana	25-31
34070757-5	2021	Anthocyanins, water-soluble flavonoid species, responsible for the red-blue color in plants and commonly found in berries, exert favorable effects on the endothelial function, oxidative stress, inhibit COX-1, and COX-2 enzymes, exert antiatherogenic, antihypertensive, antiglycation, antithrombotic, and anti-inflammatory activity, ameliorate dyslipidemia and arterial stiffness.	Water	14-19	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	202-207
24269698-3	2014	Previously, we have shown that water-damaged building associated trichothecene mycotoxins, including roridin A, trigger IL-1beta and IL-18 secretion in human macrophages.	Water	31-36	interleukin 18	Homo sapiens	133-138
34853615-1	2021	The regression and salinization of the Aral Sea, largely caused by water diversion for irrigation, is among the most severe ecological disasters of the 20th century, and has had severe health and economic consequences for the local population.	Water	67-72	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	44-47
24127653-8	2014	In addition, the highest infection risk was 1 caused by HAdV in surface water at the slum outlet, while the lowest infection risk was 2.71 x 10(-6) caused by E. coli O157:H7 in tap water.	Water	181-186	nuclear RNA export factor 1	Homo sapiens	177-180
34069360-8	2021	The oil/water emulsion permeability was improved by three-fold from 45 +- 0 to 139 +- 1 L/(m2 h bar) for PSF/PEG-0 membrane in comparison to the most optimum one of PSF/PEG-60.	Water	8-13	progestagen associated endometrial protein	Homo sapiens	109-112
24292023-3	2014	From our previous work, we know that MDG-1, a water-soluble beta-D-fructan polysaccharide from O. japonicas could treat T2DM experimentally.	Water	46-51	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	37-42
34602699-5	2021	We also disclose the cooperative reactivity of 1/ZnX2 pairs (X = Cl, Br, I, and OTf) toward water and dihydrogen, which can be understood in terms of bimetallic frustration.	Water	92-97	chromosome 12 open reading frame 73	Homo sapiens	69-71
24356448-0	2014	A novel human aquaporin-4 splice variant exhibits a dominant-negative activity: a new mechanism to regulate water permeability.	Water	108-113	aquaporin 4	Homo sapiens	14-25
24356448-5	2014	Furthermore, the water transport activity of the cotransfectants is diminished in comparison to transfectants expressing only AQP4.	Water	17-22	aquaporin 4	Homo sapiens	126-130
34163834-1	2021	In this work, spectroelectrochemical techniques are employed to analyse the catalytic water oxidation performance of a series of three nickel/iron oxyhydroxide electrocatalysts deposited on FTO and BiVO4, at neutral pH.	Water	86-91	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	190-193
24356448-6	2014	The observed down-regulation of both the expression and water channel activity of AQP4 is likely to originate from a dominant-negative effect caused by heterodimerization between AQP4 and AQP4-Delta4, which was detected in coimmunoprecipitation studies.	Water	56-61	aquaporin 4	Homo sapiens	82-86
24356448-6	2014	The observed down-regulation of both the expression and water channel activity of AQP4 is likely to originate from a dominant-negative effect caused by heterodimerization between AQP4 and AQP4-Delta4, which was detected in coimmunoprecipitation studies.	Water	56-61	aquaporin 4	Homo sapiens	179-183
24356448-6	2014	The observed down-regulation of both the expression and water channel activity of AQP4 is likely to originate from a dominant-negative effect caused by heterodimerization between AQP4 and AQP4-Delta4, which was detected in coimmunoprecipitation studies.	Water	56-61	aquaporin 4	Homo sapiens	179-183
34153284-3	2021	It has been proposed that Ces1d/CES1 might also catalyze cholesteryl ester (CE) hydrolysis in the liver and be responsible for the hydrolysis of high-density lipoprotein (HDL)-derived CE, thus contributing to the final step in the reverse cholesterol transport (RCT) pathway, where cholesterol is secreted from the liver into bile and feces, either directly or after conversion to water-soluble bile salts.	Water	381-386	carboxylesterase 1D	Mus musculus	26-31
24487453-0	2014	Risk factors associated with the choice to drink bottled water and tap water in rural Saskatchewan.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
35398068-1	2022	The Bohai Sea is one of the most polluted hotspots by per- and Polyfluoroalkyl substances (PFASs) in the world and studies on the vertical distribution of PFASs at different water layers and phase partitioning between water and suspended particulate matter (SPM) were still limited.	Water	174-179	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	10-13
24487453-1	2014	A cross-sectional study investigated risk factors associated with choices to drink bottled water and tap water in rural Saskatchewan.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
24487453-4	2014	Those who reported tap water was not safe to drink were more likely to choose bottled water, an effect greater for those who had no aesthetic complaints (p &lt;= 0.001), while those with aesthetic complaints were more likely to choose bottled water if they believed the water was safe (p &lt; 0.001).	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
24487453-4	2014	Those who reported tap water was not safe to drink were more likely to choose bottled water, an effect greater for those who had no aesthetic complaints (p &lt;= 0.001), while those with aesthetic complaints were more likely to choose bottled water if they believed the water was safe (p &lt; 0.001).	Water	86-91	nuclear RNA export factor 1	Homo sapiens	19-22
24487453-4	2014	Those who reported tap water was not safe to drink were more likely to choose bottled water, an effect greater for those who had no aesthetic complaints (p &lt;= 0.001), while those with aesthetic complaints were more likely to choose bottled water if they believed the water was safe (p &lt; 0.001).	Water	86-91	nuclear RNA export factor 1	Homo sapiens	19-22
24487453-4	2014	Those who reported tap water was not safe to drink were more likely to choose bottled water, an effect greater for those who had no aesthetic complaints (p &lt;= 0.001), while those with aesthetic complaints were more likely to choose bottled water if they believed the water was safe (p &lt; 0.001).	Water	86-91	nuclear RNA export factor 1	Homo sapiens	19-22
24487453-6	2014	A similar pattern of risk factors was associated with a decreased likelihood of consuming tap water daily; however, the use of a community water supply was not significant.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
35398068-1	2022	The Bohai Sea is one of the most polluted hotspots by per- and Polyfluoroalkyl substances (PFASs) in the world and studies on the vertical distribution of PFASs at different water layers and phase partitioning between water and suspended particulate matter (SPM) were still limited.	Water	218-223	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	10-13
24316265-8	2014	Polarized microscopy revealed a LC boundary spontaneously formed at the water/ME interface for the LC-MEs with the LC-ME2 forming a substantially thicker LC layer.	Water	72-77	NAD-dependent malic enzyme, mitochondrial	Oryctolagus cuniculus	118-121
35439494-4	2022	Thus, to tackle this challenge, TX-100 SnO2 nanoparticles based chemically modified sensor is introduced to assess the quantity of Cd+2 in the water system.	Water	143-148	CD2 molecule	Homo sapiens	131-135
35439494-6	2022	Under the optimized conditions e.g., scan rate 80 mV/s, PBS electrolyte pH 7, and potential window (-0.2 to -1.4 V), the engineered TX-100/SnO2/GCE-based sensor manifested a phenomenal response for cadmium ions in water media.	Water	214-219	guanylate cyclase 2E, pseudogene	Homo sapiens	144-147
35439494-9	2022	Moreover, the excellent stability and anti-interference behavior of the sensor highlights its dynamic profile to be commercially utilized for the determination of Cd+2 ions in water bodies.	Water	176-181	CD2 molecule	Homo sapiens	163-167
35561800-2	2022	In this work, a facile protocol to fabricate robust poly-lactic acid (PLA) coated cellulose foams (PCCF) was developed through a combined water-based foaming and PLA melt-coating process using pulp as the raw material.	Water	138-143	coagulation factor V	Homo sapiens	99-103
24432356-1	2014	The vermilion lip is a body site particularly susceptible to water loss.	Water	61-66	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	14-17
24417880-11	2014	In addition, continuous administration of rhodiola-water extract for 3 days in STZ-diabetic rats resulted in an increased expression of glucose transporter subtype 4 (GLUT 4) in skeletal muscle and a marked reduction of phosphoenolpyruvate carboxykinase (PEPCK) expression in liver.	Water	51-56	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	220-253
24417880-11	2014	In addition, continuous administration of rhodiola-water extract for 3 days in STZ-diabetic rats resulted in an increased expression of glucose transporter subtype 4 (GLUT 4) in skeletal muscle and a marked reduction of phosphoenolpyruvate carboxykinase (PEPCK) expression in liver.	Water	51-56	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	255-260
35561800-5	2022	Specifically, the low-density PCCF were observed with mechanical strength up to 81.24 kPa, high water stability, and more than 95% degradation in 56 days.	Water	96-101	coagulation factor V	Homo sapiens	30-34
35500487-4	2022	Analyses showed that saltwater intrusion and sea level rise can significantly affect the integrity of water and wastewater collection pipes due to potential changes in soil and groundwater characteristics that increase corrosion rates.	Water	102-107	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	45-48
24344770-1	2014	An arylpalladium PNF-type pincer complex reacts with water and anilines under very mild conditions, providing access to new PNO- and PNN-pincer complexes with concomitant hydrogen transfer to the ligand core.	Water	53-58	pinin, desmosome associated protein	Homo sapiens	133-136
35346838-4	2022	Despite this progress, the main limitation of dMRI remains: it does not image axons directly, but only provides indirect measurements based on the diffusion of water molecules.	Water	160-165	mrityu	Drosophila melanogaster	46-50
25576979-7	2014	The change in brain water content was consistent with the MMP-9 level.	Water	20-25	matrix metallopeptidase 9	Rattus norvegicus	58-63
25236726-9	2014	Studies using mice lacking the equilibrative nucleoside transporter 1 have illuminated how adenosine functions through neuroglial interactions involving glutamate uptake transporter GLT-1 [referred to as excitatory amino acid transporter 2 (EAAT2) in human] and possibly water channel aquaporin 4 to regulate ethanol sensitivity, reward-related motivational processes, and alcohol intake.	Water	271-276	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	182-187
25236726-9	2014	Studies using mice lacking the equilibrative nucleoside transporter 1 have illuminated how adenosine functions through neuroglial interactions involving glutamate uptake transporter GLT-1 [referred to as excitatory amino acid transporter 2 (EAAT2) in human] and possibly water channel aquaporin 4 to regulate ethanol sensitivity, reward-related motivational processes, and alcohol intake.	Water	271-276	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	204-239
25236726-9	2014	Studies using mice lacking the equilibrative nucleoside transporter 1 have illuminated how adenosine functions through neuroglial interactions involving glutamate uptake transporter GLT-1 [referred to as excitatory amino acid transporter 2 (EAAT2) in human] and possibly water channel aquaporin 4 to regulate ethanol sensitivity, reward-related motivational processes, and alcohol intake.	Water	271-276	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	241-246
24265678-7	2013	Here we demonstrate that the Abeta infused rats showed impairment in cognitive performances in the Morris water maze task 4 weeks after Abeta25-35 infusion and that this impairing effect was prevented by SP administration.	Water	106-111	amyloid beta precursor protein	Rattus norvegicus	29-34
24083507-4	2013	Simulations for one odd and one even SAM (C14 and C15) systems have revealed interesting odd-even effects in water penetration and frictional properties.	Water	109-114	placenta associated 8	Homo sapiens	50-53
35430311-2	2022	These organisms can transfer more harmful forms of Se to higher trophic levels via dietary pathways, although much uncertainty remains around this step of Se assimilation due to site-specific differences in water chemistry, hydrological and biogeochemical characteristics, and community composition.	Water	207-212	squalene epoxidase	Homo sapiens	155-157
23597848-6	2013	Diffusion of albumin into the nonburn region, where water content was increased, was limited.	Water	52-57	albumin	Rattus norvegicus	13-20
24192288-1	2014	In the membrane fraction of mouse parotid gland (PG), the protein level of aquaporin 5 (AQP5), a member of the water channel family, was increased by injection (ip) of isoproterenol (IPR), a beta-adrenergic agonist, at 1 h, and stayed at high levels until 6 h; this change occurred simultaneously as amylase secretion.	Water	111-116	aquaporin 5	Mus musculus	75-86
24192288-1	2014	In the membrane fraction of mouse parotid gland (PG), the protein level of aquaporin 5 (AQP5), a member of the water channel family, was increased by injection (ip) of isoproterenol (IPR), a beta-adrenergic agonist, at 1 h, and stayed at high levels until 6 h; this change occurred simultaneously as amylase secretion.	Water	111-116	aquaporin 5	Mus musculus	88-92
23597848-8	2013	The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue.	Water	63-68	albumin	Rattus norvegicus	125-132
35427769-1	2022	Diffu0sion-weighted magnetic resonance imaging (dMRI) is a non-invasive imaging technique that provides information about the barriers to the diffusion of water molecules in tissue.	Water	155-160	mrityu	Drosophila melanogaster	48-52
23838197-5	2013	Results show that the adsorption process of DGL at the lipid/water interface depends on a pH-dependent adsorption equilibrium coefficient which is optimum at pH 5.0 (K(Ads) = 1.7 +- 0.05 x 10(8)M(-1)).	Water	61-66	lipase F, gastric type	Canis lupus familiaris	44-47
25281816-8	2014	The conducted tests demonstrated that microfungi were found in tap water originating from the cities and in bottled water.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
25281816-10	2014	Eighteen species of microfungi were identified in tap water from Olsztyn and 9 species in tap water from Ostroleka.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
35278445-10	2022	Notably, even the participants with 10.1-50 mug/L arsenic in drinking water had significantly higher levels of periostin than participants with <10 mug/L of water arsenic.	Water	70-75	periostin	Homo sapiens	111-120
23709255-11	2013	CONCLUSION: TRPV1 is expressed in cells that are particularly active in Ca2+ exchange as well as in cells with significant water transport activity.	Water	123-128	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	12-17
23709255-12	2013	Because TRPV1 is a Ca2+ channel, it probably functions in the regulation of both water and Ca2+ movements in ocular tissues.	Water	81-86	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	8-13
35616516-3	2022	Here, we study, through molecular simulations, the hydration and binding free energies of an amphiphilic peptide from the nonamyloid-beta component (NAC), a key aggregation-prone domain of alpha-synuclein, in water and an 8 M aqueous urea solution.	Water	209-214	synuclein alpha	Homo sapiens	189-204
24175655-10	2013	These results demonstrated that orally administered water-soluble undenatured C II (NEXT-II) is highly efficacious in the suppression of CIA by inducing CD4+CD25+ Treg cells.	Water	52-57	interleukin 2 receptor, alpha chain	Mus musculus	157-161
25227799-3	2014	17-AAG has poor water-solubility which is a potential problem for clinical practice.	Water	16-21	N-methylpurine DNA glycosylase	Homo sapiens	3-6
25530970-7	2014	The Cd in drinking water also resulted in the rural respondents having significantly higher urinary NAG which had a significant relationship with urinary Cd.	Water	19-24	NBAS subunit of NRZ tethering complex	Homo sapiens	100-103
35182619-0	2022	Personal protective equipment (PPE) pollution in the Caspian Sea, the largest enclosed inland water body in the world.	Water	94-99	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	61-64
24383074-4	2014	The radical Cl2(- ) would also be a major oxidant of nitrite to the nitrating agent ( )NO2 in brackish- and salt-water.	Water	113-118	endogenous retrovirus group W member 5	Homo sapiens	12-15
35150954-9	2022	The 3D CoP 5CoMoP heterostructured catalysts hold promise as efficient and low-cost catalysts for water splitting devices over a wide pH range.	Water	98-103	caspase recruitment domain family member 16	Homo sapiens	7-10
25203343-0	2014	[Impact of SPA therapy with sulphureous mineral water on quality of life and psychological distress in chronic plaque psoriasis].	Water	48-53	surfactant protein A2	Homo sapiens	11-14
35616204-27	2022	The LOQs of the THMs in the GB/T 5750.8-2006 Standard Test Method of Drinking Water Organic Matter Index are 0.3-6.0 mug/L.	Water	78-83	TARBP2 subunit of RISC loading complex	Homo sapiens	4-8
24497546-3	2014	Recent evidence shows that Arf1/COPI can bud nano-LDs (~60 nm diameter) from phospholipid-covered oil/water interfaces in vitro.	Water	102-107	ADP ribosylation factor 1	Homo sapiens	27-31
35613275-0	2022	Changing spatial distribution of water flow charts major change in Mars"s greenhouse effect.	Water	33-38	methionyl-tRNA synthetase 1	Homo sapiens	67-71
24270323-0	2014	Magnetically recoverable fluorescence chemosensor for the adsorption and selective detection of Hg2+ in water.	Water	104-109	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	96-99
35636297-3	2022	The electron transfer from Co-B to Ru may result in the easier water dissociation step so as to facilitate the catalytic process.	Water	63-68	metabolism of cobalamin associated B	Homo sapiens	27-31
24728544-1	2014	The aims of this study are to investigate the presence of 30 substances known or thought to act as endocrine disrupting compounds in tap water from the main water supply areas for region of Madrid, to determine the total estrogenic activity of the samples analysed and to estimate the health risk for the population resulting from those compounds found at detectable concentrations.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
24728544-5	2014	Tap water in the region of Madrid is contaminated with traces (ng/L) of compounds with endocrine disrupting properties.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
35124059-5	2022	Industrial Water Use (IWU), Primary Energy Demand (PED) and SO2 are major factors affecting results of PPH-EB, which mainly come from polypropylene particles and water resource consumption from recycle process.	Water	11-16	enolase 1	Homo sapiens	103-106
24756667-1	2014	The electrochemical degradation of the nonsteroidal anti-inflammatory drug ketoprofen in tap water has been studied using electro-Fenton (EF) and anodic oxidation (AO) processes with platinium (Pt) and boron-doped diamond (BDD) anodes and carbon felt cathode.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
35124059-5	2022	Industrial Water Use (IWU), Primary Energy Demand (PED) and SO2 are major factors affecting results of PPH-EB, which mainly come from polypropylene particles and water resource consumption from recycle process.	Water	162-167	enolase 1	Homo sapiens	103-106
24382119-4	2014	Compared to the total number of tap water samples analyzed (122), the values higher than limits of Directive 98/83/EC were 17% for lead, 11% for nickel, 14% for zinc, and 7% for iron.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
35586975-10	2022	In conclusion, 20% CP is beneficial to the normal expression of AQP4 in the small intestine, AQP2, AQP4 and AQP9 in the colon of weaned piglets, which in turn maintains the balance of intestinal water absorption and secretion in piglets.	Water	195-200	ceruloplasmin	Homo sapiens	19-21
25400979-2	2014	More specifically, the headspace solid-phase microextraction coupled to gas chromatography mass spectrometry (HS-SPME/GC-MS) was applied to determine the levels of GSM and 2-MIB in water samples, and the samples were collected depending on water sources, conventional treatment processes, and seasons.	Water	181-186	MIB E3 ubiquitin protein ligase 1	Homo sapiens	174-177
35583269-5	2022	For the first time, we showed that different concentrations of TEPP diluted in water after adsorption experiments using cork granules decreased TEPP"s inhibitory effects on AChE activity in commercial enzyme and neuronal PC12 cell culture medium.	Water	79-84	acetylcholinesterase	Rattus norvegicus	173-177
25400979-3	2014	The significant difference was shown for the 2-MIB levels of source water (P &lt; 0.05), the concentrations of GSM and 2-MIB decreased significantly as treatment process of tap water moved forward (P &lt; 0.0001), and the significant differences for the levels of GSM and 2-MIB were observed among three sampling periods (P &lt; 0.01).	Water	68-73	MIB E3 ubiquitin protein ligase 1	Homo sapiens	47-50
25400979-4	2014	The levels of GSM and 2-MIB in all water samples were lower than 10 ng L(-1), the odor threshold concentration (OTC), and the conventional treatment process plays a significant role in removing odorants in tap water.	Water	35-40	MIB E3 ubiquitin protein ligase 1	Homo sapiens	24-27
35581939-8	2022	These findings provide novel insight into CDK12 being necessary for maintaining renal homeostasis by regulating NKCC2 transcription, which explains the critical water and electrolyte disturbance that occurs during the application of CDK12 inhibitors for cancer treatment.	Water	161-166	cyclin-dependent kinase 12	Mus musculus	42-47
25421594-0	2014	Water-extracted Ampelopsis brevipedunculata downregulates IL-1beta,CCL5, and COX-2 expression via inhibition of PKC-mediated JNK/NF-kappaB signaling pathways in human monocytic cells.	Water	0-5	C-C motif chemokine ligand 5	Homo sapiens	67-71
25421594-4	2014	THP-1 cells activated by PMA in the presence or absence of A.bre demonstrated that a water-extract of A.bre inhibited the expression of pro-inflammatory cytokine IL-1beta and chemokine CCL-5 in a dose-dependent manner.	Water	85-90	C-C motif chemokine ligand 5	Homo sapiens	185-190
25421594-8	2014	Collectively, our data showed that water-extracted A.bre inhibited the protein kinase C-JNKs/NF-kappaB signaling pathways, resulting in the suppression of IL-1beta, CCL-5, and COX-2 expression.	Water	35-40	C-C motif chemokine ligand 5	Homo sapiens	165-170
35581939-8	2022	These findings provide novel insight into CDK12 being necessary for maintaining renal homeostasis by regulating NKCC2 transcription, which explains the critical water and electrolyte disturbance that occurs during the application of CDK12 inhibitors for cancer treatment.	Water	161-166	cyclin-dependent kinase 12	Mus musculus	233-238
35074374-0	2022	Cortex metabolome and proteome analysis reveals chronic arsenic exposure via drinking water induces developmental neurotoxicity through hnRNP L mediated mitochondrial dysfunction in male rats.	Water	86-91	heterogeneous nuclear ribonucleoprotein L	Rattus norvegicus	136-143
35532096-2	2022	A readily available water-soluble, macrocyclic host, cucurbit(7)uril (CB(7)), effectively inhibits IAPP aggregation by ion-dipole and hydrophobic interactions with different residues of the monomeric peptide in its random coil conformation.	Water	20-25	islet amyloid polypeptide	Rattus norvegicus	99-103
24336404-2	2014	Various water-splitting methods have been investigated previously, but the use of photocatalysts to split water into stoichiometric amounts of H2 and O2 (overall water splitting) without the use of external bias or sacrificial reagents is of particular interest because of its simplicity and potential low cost of operation.	Water	8-13	relaxin 2	Homo sapiens	143-152
24336404-2	2014	Various water-splitting methods have been investigated previously, but the use of photocatalysts to split water into stoichiometric amounts of H2 and O2 (overall water splitting) without the use of external bias or sacrificial reagents is of particular interest because of its simplicity and potential low cost of operation.	Water	106-111	relaxin 2	Homo sapiens	143-152
35411895-2	2022	A novel water-stable metal organic framework material (Cd2(Hdpb)(H2O)3) (Cd-MOF) was synthesized based on H5dpb (H5dpb = 3,5-diphosphonobenzoic acid) and Cd2+ ions.	Water	8-13	CD2 molecule	Homo sapiens	55-58
23673346-6	2014	The feasibility of this method was demonstrated in tap-water and a tap-water filled cavity in the tissue-mimicking gelatin-agar phantom as capable of observing temporal evolutions of cavitation bubble cloud with temporal resolution of several microseconds, lateral and axial resolution of 0.50 mm and 0.29 mm respectively.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
23673346-6	2014	The feasibility of this method was demonstrated in tap-water and a tap-water filled cavity in the tissue-mimicking gelatin-agar phantom as capable of observing temporal evolutions of cavitation bubble cloud with temporal resolution of several microseconds, lateral and axial resolution of 0.50 mm and 0.29 mm respectively.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
35411895-2	2022	A novel water-stable metal organic framework material (Cd2(Hdpb)(H2O)3) (Cd-MOF) was synthesized based on H5dpb (H5dpb = 3,5-diphosphonobenzoic acid) and Cd2+ ions.	Water	8-13	CD2 molecule	Homo sapiens	154-157
35411895-2	2022	A novel water-stable metal organic framework material (Cd2(Hdpb)(H2O)3) (Cd-MOF) was synthesized based on H5dpb (H5dpb = 3,5-diphosphonobenzoic acid) and Cd2+ ions.	Water	65-68	CD2 molecule	Homo sapiens	55-58
35411895-2	2022	A novel water-stable metal organic framework material (Cd2(Hdpb)(H2O)3) (Cd-MOF) was synthesized based on H5dpb (H5dpb = 3,5-diphosphonobenzoic acid) and Cd2+ ions.	Water	65-68	CD2 molecule	Homo sapiens	154-157
25293563-4	2014	Two of three studies showed that tap water significantly lowered pH as well, but only if it was administered within 60 seconds after exposure.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
35411895-3	2022	Cd2+ ions are connected with phosphonates and carboxyl groups of H5dpb to form an infinitely extended 1D chain, which is further connected by the Hdpb4- ligand and coordinated water to form a three-dimensional network structure.	Water	176-181	CD2 molecule	Homo sapiens	0-3
35319113-6	2022	Eventually; the electronic regulations bring accelerated water dissociation and reduced energy barriers of hydroxide/hydrogen desorption on adjacent Ru sites; then an optimized reaction kinetics for Ru1,n -NC is obtained to achieve superb hydrogen generation in alkaline media.	Water	57-62	Scm like with four mbt domains 1	Homo sapiens	199-202
24436993-10	2013	MMP-2 (P &lt; 0.05) and MMP-9 (P &lt; 0.01) levels were positively correlated with spinal cord water content.	Water	95-100	matrix metallopeptidase 9	Rattus norvegicus	24-29
35114014-1	2022	The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands.	Water	4-9	aquaporin 5	Homo sapiens	31-35
24379894-9	2013	When available, the English children drank municipal tap water more often than did the Spanish children.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
23796954-6	2013	The recovery of adenovirus was highest for samples in unconditioned tap water (pH 8) using the 1MDS filter and celite for secondary concentration.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
23796954-9	2013	By optimizing secondary elution steps, AdV recovery from tap water could be improved at least two-fold compared to the currently used methodology.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
35114014-1	2022	The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands.	Water	69-74	aquaporin 5	Homo sapiens	31-35
35114014-3	2022	Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation.	Water	20-25	aquaporin 5	Homo sapiens	37-41
24091713-3	2013	The cocktail boat is a drink accessory, a self-propelled edible boat powered by alcohol-induced surface tension gradients, whose propulsion mechanism is analogous to that employed by a class of water-walking insects.	Water	194-199	ataxin 1 like	Homo sapiens	13-17
35470510-2	2022	Aquaporin 3 (AQP3) is a glycerol/ water channel involved in several physiological functions.	Water	34-39	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
24091713-3	2013	The cocktail boat is a drink accessory, a self-propelled edible boat powered by alcohol-induced surface tension gradients, whose propulsion mechanism is analogous to that employed by a class of water-walking insects.	Water	194-199	ataxin 1 like	Homo sapiens	64-68
24076339-4	2013	One was glutamic acid decarboxylase 65 (GAD65), the protein level of which was reduced to less than 50% of control in the hippocampus of hypothyroid rats (obtained by administering 0.025% methimazole in drinking water to pregnant dams from gestational day 15 until 4 weeks postpartum) and recovered to control levels by daily thyroxine-replacement after birth.	Water	212-217	glutamate decarboxylase 2	Rattus norvegicus	8-38
24125784-6	2013	In contrast, rats that received the 5-HT1B agonist CP 93129 (at 0.0, 1.0, 2.0 and 4.0 mug/0.5 mul/side) showed a significant dose-dependent decrease in water intake only; stimulation of 5-HT7 receptors (AS 19; at 0.0, 1.0, and 5.0 mug/0.5 mul/side) decreased ambulatory activity but did not affect food or water consumption.	Water	152-157	5-hydroxytryptamine receptor 1B	Rattus norvegicus	36-42
24125784-6	2013	In contrast, rats that received the 5-HT1B agonist CP 93129 (at 0.0, 1.0, 2.0 and 4.0 mug/0.5 mul/side) showed a significant dose-dependent decrease in water intake only; stimulation of 5-HT7 receptors (AS 19; at 0.0, 1.0, and 5.0 mug/0.5 mul/side) decreased ambulatory activity but did not affect food or water consumption.	Water	306-311	5-hydroxytryptamine receptor 1B	Rattus norvegicus	36-42
24090115-4	2013	The dispersion of Film-1(n)PTB in water gave only nanotapes, whereas that of Film-2eq1(n)PTB in water selectively formed nanotubes, through a dissociation reaction of PTB based on the hydrolysis of the boronate esters in the complexes.	Water	34-39	polypyrimidine tract binding protein 1	Homo sapiens	27-30
24090115-4	2013	The dispersion of Film-1(n)PTB in water gave only nanotapes, whereas that of Film-2eq1(n)PTB in water selectively formed nanotubes, through a dissociation reaction of PTB based on the hydrolysis of the boronate esters in the complexes.	Water	96-101	polypyrimidine tract binding protein 1	Homo sapiens	77-92
24090115-4	2013	The dispersion of Film-1(n)PTB in water gave only nanotapes, whereas that of Film-2eq1(n)PTB in water selectively formed nanotubes, through a dissociation reaction of PTB based on the hydrolysis of the boronate esters in the complexes.	Water	96-101	polypyrimidine tract binding protein 1	Homo sapiens	89-92
24076339-4	2013	One was glutamic acid decarboxylase 65 (GAD65), the protein level of which was reduced to less than 50% of control in the hippocampus of hypothyroid rats (obtained by administering 0.025% methimazole in drinking water to pregnant dams from gestational day 15 until 4 weeks postpartum) and recovered to control levels by daily thyroxine-replacement after birth.	Water	212-217	glutamate decarboxylase 2	Rattus norvegicus	40-45
35470510-2	2022	Aquaporin 3 (AQP3) is a glycerol/ water channel involved in several physiological functions.	Water	34-39	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
35514354-2	2022	We provided evidence that high calcium delivery to the collecting duct reduces local Aquaporin 2 (AQP2)-mediated water reabsorption under vasopressin action, thus limiting the maximal urinary concentration to reduce calcium saturation.	Water	113-118	aquaporin 2	Homo sapiens	85-96
24121503-8	2013	Analysis of the crystal structure along with the present results provide fundamental insights into the activation mechanism of the KOR and suggest that "functional" residues, along with water molecules detected in the crystal structure, may be directly involved in transduction of the agonist binding event into structural changes at the conserved rotamer switches, thus leading to receptor activation.	Water	186-191	opioid receptor kappa 1	Homo sapiens	131-134
24022263-8	2013	Finally, OKE spectroscopy on pH2 solids with oH2 concentrations of 1-3% shows evidence for extremely long-lived rotational coherences which likely correspond to J = 2 rotons that are pinned next to single oH2 impurities within the pH2 solid.	Water	45-48	polyhomeotic homolog 2	Homo sapiens	29-32
35514354-2	2022	We provided evidence that high calcium delivery to the collecting duct reduces local Aquaporin 2 (AQP2)-mediated water reabsorption under vasopressin action, thus limiting the maximal urinary concentration to reduce calcium saturation.	Water	113-118	aquaporin 2	Homo sapiens	98-102
24030544-5	2013	The efficiency of Cat1 has been compared under the same experimental conditions to those of three other H2-evolving catalysts, which are known to operate in water, [Co{(DO)(DOH)pn}Br2] (Cat2), [Co(dmbpy)3]Cl2 (Cat3) and [Rh(dmbpy)2Cl2]Cl (Cat4).	Water	157-162	transient receptor potential cation channel subfamily V member 6	Homo sapiens	18-22
35479105-2	2022	The as-prepared Fe3O4@SiO2@KCC-1@MPTMS@CuII mesoporous nanocomposite exhibited satisfactory catalytic activity in the reduction and reductive acetylation of nitroarenes in a water medium and solvent-free one-pot synthesis of some coumarin compounds including 3,3"-(arylmethylene)bis(4-hydroxy-2H-chromen-2-ones) (namely, bis-coumarins) (3a-n) and 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles (6a-n) along with acceptable turnover numbers (TONs) and turnover frequencies (TOFs).	Water	174-179	solute carrier family 12 member 4	Homo sapiens	27-32
24156724-5	2013	Oral administration of vasopressin V1a receptor antagonist, SR 49059, significantly reduced the cerebral water content in the GET-1 mice.	Water	105-110	arginine vasopressin receptor 1A	Mus musculus	23-47
24081306-3	2013	The change of the working gas from zero air to N2 allows us to change the major reactant ions from NO(+) (H2O)n to H3O(+) (H2O)n. In this paper we present the description of the new CD-APCI and discuss the processes associated with the NO(+) formation.	Water	106-109	H3 clustered histone 15	Homo sapiens	115-121
24081306-3	2013	The change of the working gas from zero air to N2 allows us to change the major reactant ions from NO(+) (H2O)n to H3O(+) (H2O)n. In this paper we present the description of the new CD-APCI and discuss the processes associated with the NO(+) formation.	Water	123-126	H3 clustered histone 15	Homo sapiens	115-121
24156724-5	2013	Oral administration of vasopressin V1a receptor antagonist, SR 49059, significantly reduced the cerebral water content in the GET-1 mice.	Water	105-110	activating transcription factor 7 interacting protein 2	Mus musculus	126-131
35440619-3	2022	Here we show, using mooring observations, that a previous unknown intermediate western boundary current (with the core at ~1000 m depth) exists in the Maluku Sea, which transports intermediate waters (primarily the Antarctic Intermediate Water) from the Pacific into the Seram-Banda Seas through the Lifamatola Passage above the bottom overflow.	Water	238-243	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	158-161
23992844-1	2013	An analytical method based on on-line solid-phase extraction coupled to liquid chromatography with fluorescence detection has been developed to determine quinolones in tap water and human urine.	Water	172-177	nuclear RNA export factor 1	Homo sapiens	168-171
24089197-4	2013	The thorough chemical-physical characterization of the conformational behavior of free and zinc-bound MBET306 in water bulk solution opens new avenues for the rational drug design of tartrate-based highly specific TACE inhibitors.	Water	113-118	ADAM metallopeptidase domain 17	Homo sapiens	214-218
24144041-7	2013	However, the particle concentration of the filtered water from the AWM was still four times higher than that found in regular tap water.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	126-129
23992844-5	2013	The method allowed the determination of 11 quinolones directly in tap water samples in less than 20 min and with limits of detection ranging between 7 and 110 ng/L.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
24144041-7	2013	However, the particle concentration of the filtered water from the AWM was still four times higher than that found in regular tap water.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
35220763-7	2022	Our predictions suggest that if the mean sea-level were to increase by 1 m in the Batticaloa region (Sri Lanka), this would cause landward communities to be inundated with brackish water at various depths.	Water	181-186	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	41-44
24148248-7	2013	AQP5-KO lenses displayed osmotic swelling due to increase in water content.	Water	61-66	aquaporin 5	Mus musculus	0-4
24150760-5	2013	METHODS: EAU was induced in B10.A mice by immunization with interphotoreceptor retinoid-binding protein (IRBP; 40 mug) in CFA.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	60-103
24150760-5	2013	METHODS: EAU was induced in B10.A mice by immunization with interphotoreceptor retinoid-binding protein (IRBP; 40 mug) in CFA.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	105-109
24489483-4	2013	BBB opening is accompanied by edema formation using astrocytic AQP4 as a key protein regulating water movement.	Water	96-101	aquaporin 4	Homo sapiens	63-67
24552061-7	2013	Six T&amp;O compounds (IPMP, IBMP, trans,cis-2,6-nonadienal, 2-methylbenzofuran, trans-2-decenal, and TCA) were effectively decreased in water treatment process (sedimentation and filtration) that is different from cis-3-hexenyl acetate, MIB and geosmin.	Water	137-142	suppressor of cytokine signaling 2	Homo sapiens	41-46
24019225-0	2013	A convenient and sensitive method for haloacetic acid analysis in tap water by on-line field-amplified sample-stacking CE-ESI-MS.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
24019225-1	2013	In this study, we propose a simple strategy based on flow injection and field-amplified sample-stacking CE-ESI-MS/MS to analyze haloacetic acids (HAAs) in tap water.	Water	159-164	nuclear RNA export factor 1	Homo sapiens	155-158
24019225-2	2013	Tap water was passed through a desalination cartridge before field-amplified sample-stacking CE-ESI-MS/MS analysis to reduce sample salinity.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
24138873-0	2013	Peri-ictal water drinking and other ictal vegetative symptoms: Localizing and lateralizing the epileptogenic zone in temporal lobe epilepsy?	Water	11-16	perilipin 1	Homo sapiens	0-4
24252623-6	2013	In early and remitting EAE, upregulated GFAP and astrocytic endfoot water channel aquaporin 4 (AQP4) enclosed white matter lesions in spinal cord, whereas they markedly increased and formed bundles in exacerbated lesions in late EAE.	Water	68-73	aquaporin 4	Mus musculus	95-99
24044418-5	2013	Heating of the tap water with low pH led to a more significant increase of chloroform and a more significant short-term increase of DCAN.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
23868847-10	2013	These data indicate that the Atlantic salmon Aqp8 paralogs have neofunctionalized on a transcriptional as well as a functional level, and that Aqp8ab may play a central role in the intestinal transcellular uptake of water during SW acclimation.	Water	216-221	aquaporin 8a, tandem duplicate 2	Salmo salar	143-149
23958801-1	2013	Intra- and intermolecular force field parameters for the interaction of actinyl ions (AnO2(n+), where, An = U, Np, Pu, Am and n = 1, 2) with water have been developed using quantum mechanical calculations.	Water	141-146	anoctamin 2	Homo sapiens	86-90
23769186-5	2013	TCAA level in home tap water supply was not correlated with urinary TCAA (0.18, P=0.29).	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
23769186-6	2013	Cold unfiltered tap water intake at home measured by questionnaire was correlated with urinary TCAA (0.44, P=0.007), but correlation was stronger still for cold unfiltered tap water intake reported over the 3 days prior to urine sampling (0.60, P&lt;0.001).	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
24051376-2	2013	Here we show that mice deficient in ATP6V1B1 (Atp6v1b1-/- mice) displayed renal loss of NaCl, K+, and water, causing hypovolemia, hypokalemia, and polyuria.	Water	102-107	ATPase, H+ transporting, lysosomal V1 subunit B1	Mus musculus	36-44
24051376-2	2013	Here we show that mice deficient in ATP6V1B1 (Atp6v1b1-/- mice) displayed renal loss of NaCl, K+, and water, causing hypovolemia, hypokalemia, and polyuria.	Water	102-107	ATPase, H+ transporting, lysosomal V1 subunit B1	Mus musculus	46-54
23957745-0	2013	Glucagon-like peptide-1 receptor agonist administration suppresses both water and saline intake in rats.	Water	72-77	glucagon	Rattus norvegicus	0-23
23957745-4	2013	GLP-1R agonists suppress water intake independent of their effects on food intake.	Water	25-30	glucagon-like peptide 1 receptor	Rattus norvegicus	0-6
23957745-6	2013	Accordingly, we tested the effect of the GLP-1R agonists liraglutide (0.05 mug) and exendin-4 (0.05 mug) on water and saline intake, as stimulated either by angiotensin II (AngII) or by water deprivation with partial rehydration (WD-PR).	Water	108-113	glucagon-like peptide 1 receptor	Rattus norvegicus	41-47
23957745-13	2013	Overall, these results indicate that the fluid intake suppression by GLP-1R activation is not selective to water intake, is a function of post-ingestive feedback, and is not secondary to visceral malaise.	Water	107-112	glucagon-like peptide 1 receptor	Rattus norvegicus	69-75
24303184-6	2013	Intake of drinking water was increased by +0.8 +- 0.3 L/day in period 2, and +1.5 +- 0.3 L/day in period 3, and returned to baseline intake (0.4 +- 0.2 L/day) in period 4.	Water	19-24	period circadian regulator 2	Homo sapiens	63-71
24146244-9	2013	RESULTS: Soldiers who ate breakfast regularly (6 times/week or more), drank 7 servings or more of water/day, and met weekly exercise recommendations were more likely to be in the highest HES-5 quartile than those who did not.	Water	98-103	hes family bHLH transcription factor 5	Homo sapiens	187-192
23855444-2	2013	The aim of study was to determine the extent of the pressor response and changes of sympathetic activity biomarker salivary alpha-amylase (sAA) after water ingestion in young healthy subjects.	Water	150-155	amylase alpha 1A	Homo sapiens	115-137
23855444-2	2013	The aim of study was to determine the extent of the pressor response and changes of sympathetic activity biomarker salivary alpha-amylase (sAA) after water ingestion in young healthy subjects.	Water	150-155	amylase alpha 1A	Homo sapiens	139-142
23855444-3	2013	Compared with ingestion of 50 mL of water, the blood pressure, total peripheral resistance and sAA significantly increased and the plasma osmolality decreased 25 min after drinking 500 mL of water.	Water	36-41	amylase alpha 1A	Homo sapiens	95-98
23855444-3	2013	Compared with ingestion of 50 mL of water, the blood pressure, total peripheral resistance and sAA significantly increased and the plasma osmolality decreased 25 min after drinking 500 mL of water.	Water	191-196	amylase alpha 1A	Homo sapiens	95-98
24040477-13	2013	According to our results, consuming 16 C water, cool tap water, could be suggested in dehydration.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
23793787-2	2013	An IgG autoantibody that binds to aquaporin-4 (AQP4), the predominant water channel of the CNS, is a reliable biomarker of the NMO spectrum disorders, and if detected predicts the recurrence of the myelitis.	Water	70-75	aquaporin 4	Homo sapiens	34-45
23793787-2	2013	An IgG autoantibody that binds to aquaporin-4 (AQP4), the predominant water channel of the CNS, is a reliable biomarker of the NMO spectrum disorders, and if detected predicts the recurrence of the myelitis.	Water	70-75	aquaporin 4	Homo sapiens	47-51
23937312-0	2013	Theoretical investigation of the reaction mechanism of ClONO2 + HCl   HNO3 + Cl2 on (H2O)n (n = 0-3) cluster.	Water	85-88	endogenous retrovirus group W member 5	Homo sapiens	77-80
23977086-9	2013	Colipase increased the N-TPL stability at the lipid-water interface, so the TPL N-terminal domain probably formed functional interactions with colipase despite the absence of the C-terminal domain.	Water	52-57	colipase	Meleagris gallopavo	0-8
23743873-5	2013	The motion of the microjets is also reduced in tap water, which contains large quantities of inorganic ions that have been purposely introduced into tap water via processing in water treatment plants.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
23743873-5	2013	The motion of the microjets is also reduced in tap water, which contains large quantities of inorganic ions that have been purposely introduced into tap water via processing in water treatment plants.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	149-152
23822900-3	2013	Of the liquid media, sweat and urine yielded the highest amount of silver release, up to 38% of the silver mass in products; tap water yielded the lowest amount, &lt;=1.5%.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
23876035-0	2013	Water slug formation and motion in gas flow channels: the effects of geometry, surface wettability, and gravity.	Water	0-5	snail family transcriptional repressor 2	Homo sapiens	6-10
23876035-11	2013	Residual water left behind in corners by moving slugs reduces the barriers for drops to form slugs, causing the steady-state slug volumes to be smaller than those seen at start-up in dry channels.	Water	9-14	snail family transcriptional repressor 2	Homo sapiens	48-52
23702900-1	2013	The formation of reactive species and free radicals in water soluble elastin hydrolysates have been investigated by pulse radiolysis and flash photolysis.	Water	55-60	elastin	Homo sapiens	69-76
23702900-3	2013	An investigation of the photochemical properties of elastin hydrolysates in water was carried out using nanosecond laser irradiation.	Water	76-81	elastin	Homo sapiens	52-59
23862564-2	2013	In contrast to the previously proposed syn-oxypalladation mechanism for acyclic monoallylic diols, calculations and experiments strongly suggest that hydrogen bonding templates a hydroxyl group and Pd addition across the alkene and provides a low energy pathway via anti-addition (anti-oxypalladation) followed by intramolecular proton transfer and anti-elimination of water.	Water	369-374	synemin	Homo sapiens	39-42
23895327-5	2013	Two patients reacted also to tap water or to normal saline, but less intensely.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
23982476-4	2013	Not only does a strong salt bridge interaction between the 6beta-COOH group of GA and Arg244 of AtGID1A play a very important role in the GA recognition of the receptor, but also an indirect water bridge interaction between the pharmacophore group 6beta-COOH of GA and the residue Tyr322 of AtGID1A is essential for the GA binding to the receptor.	Water	191-196	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	96-103
23982476-4	2013	Not only does a strong salt bridge interaction between the 6beta-COOH group of GA and Arg244 of AtGID1A play a very important role in the GA recognition of the receptor, but also an indirect water bridge interaction between the pharmacophore group 6beta-COOH of GA and the residue Tyr322 of AtGID1A is essential for the GA binding to the receptor.	Water	191-196	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	291-298
23820729-7	2013	A lack of SIRK1 expression resulted in the failure of mutant protoplasts to control water channel activity upon changes in external sucrose concentrations.	Water	84-89	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	10-15
23807022-5	2013	486) mug/day for samples cooked with tap water.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
24038606-1	2013	Spin doctor: A mononuclear ferric complex [Fe(H-5-Br-thsa)(5-Br-thsa)] H2O (1) (H2-5-Br-thsa = 5-bromo-2-hydroxybenzylidene)hydrazinecarbothioamide) was synthesized and its magnetic properties and structure were investigated by DFT calculations.	Water	71-74	spindlin 1	Homo sapiens	0-4
24086369-1	2013	Autoantibodies against aquaporin-4 (AQP4), a water channel in CNS astrocytes, are detected in ~50-80% of patients with neuromyelitis optica spectrum disorders (NMOsd), characterized by longitudinally extensive transverse myelitis (LETM) and/or optic neuritis.	Water	45-50	aquaporin 4	Homo sapiens	23-34
24086369-1	2013	Autoantibodies against aquaporin-4 (AQP4), a water channel in CNS astrocytes, are detected in ~50-80% of patients with neuromyelitis optica spectrum disorders (NMOsd), characterized by longitudinally extensive transverse myelitis (LETM) and/or optic neuritis.	Water	45-50	aquaporin 4	Homo sapiens	36-40
24058510-1	2013	Aquaporin-3 (AQP3) and aquaporin-4 (AQP4) are homologous proteins expressed in the basolateral plasma membrane of kidney collecting duct principal cells, where they mediate the exit pathway for apically reabsorbed water.	Water	214-219	aquaporin 4	Homo sapiens	23-34
24058510-1	2013	Aquaporin-3 (AQP3) and aquaporin-4 (AQP4) are homologous proteins expressed in the basolateral plasma membrane of kidney collecting duct principal cells, where they mediate the exit pathway for apically reabsorbed water.	Water	214-219	aquaporin 4	Homo sapiens	36-40
23608541-0	2013	Ultrasensitive and selective gold film-based detection of mercury (II) in tap water using a laser scanning confocal imaging-surface plasmon resonance system in real time.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
23608541-2	2013	The detection limit was as low as 0.01ng/ml for Hg(2+) ions in ultrapure and tap water based on a T-rich, single-stranded DNA (ssDNA)-modified gold film, which can be individually manipulated using specific T-Hg(2+)-T complex formation.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
23608541-5	2013	The coefficients obtained for ultrapure and tap water were 0.99902 and 0.99512, respectively, for the linear part over a range of 0.01-100ng/ml.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
23608541-6	2013	The results show that the double-effect sensor has potential for practical applications with ultra sensitivity and selectivity, especially in online or real-time monitoring of Hg(2+) ions pollution in tap water with the further improvement of portable LSCI-SPR instrument.	Water	205-210	nuclear RNA export factor 1	Homo sapiens	201-204
23864026-1	2013	This paper reports a facile, water-based and one-pot synthesis of tetrahedral Pd nanocrystals (Pd-TNPs) with high yield and good size monodispersity supported on reduced graphene oxide (RGO) nanosheets via a co-chemical reduction method.	Water	29-34	C1GALT1 specific chaperone 1	Homo sapiens	98-102
23864026-5	2013	Thus, the resultant Pd-TNPs/RGO nanohybrid, as a promising heterogeneous catalyst, might have wide potential applications in water-based catalysis systems for the future.	Water	125-130	C1GALT1 specific chaperone 1	Homo sapiens	23-27
23485912-7	2013	Residues lining the dimeric interface are also conserved in AHb1 with the exception of additional electrostatic interaction between H112 and E113 of each subunit and that involving Y119 through two water molecules.	Water	198-203	hemoglobin 1	Arabidopsis thaliana	60-64
23899570-1	2013	Tulip tree sawdust was pretreated using hot compressed water with different pretreatment severities (LogR0, 3.05-5.01) by varying reaction temperatures (180-220 C) and residence time (1-30 min).	Water	55-60	alcohol dehydrogenase iron containing 1	Homo sapiens	40-43
23601896-1	2013	The temperature-dependent kinetics for the reaction between hydrogen peroxide and chloramine water disinfectants (NH2Cl, NHCl2, and NCl3) have been determined using stopped flow-UV/Vis spectrophotometry.	Water	93-98	calpain 5	Homo sapiens	132-136
23830294-9	2013	But at the late stage of water sorption the hygroscopic expansion of GCK and VF was slightly sigmoidal with respect to their mass changes.	Water	25-30	glucokinase	Homo sapiens	69-72
23726868-9	2013	Consistently, decrease in tumor necrosis factor-alpha level, up-regulation of Bcl-2, and down-regulation of BAX and the downstream executioner caspase-3, also occurred in the hippocampus of 3xTg-AD mice after treatment with Tabiano"s spa-water, thus suggesting that it is also able to modulate inflammation and apoptosis.	Water	238-243	BCL2-associated X protein	Mus musculus	108-111
23708826-8	2013	The observation of the (SCN)2( -) transient in microemulsions demonstrates that it is possible to have the protonated beta-carboline and at least two thiocyanate ions in the same water pool.	Water	179-184	growth factor independent 1 transcriptional repressor	Homo sapiens	24-29
23545439-3	2013	AQP4 is a bidirectional water channel expressed on the plasma membranes of astrocytes, retinal Muller cells, skeletal muscle, and some epithelial cells in kidney, lung and the gastrointestinal tract.	Water	24-29	aquaporin 4	Homo sapiens	0-4
23937937-7	2013	Different water samples were examined, including deionized, tap, and river waters, and sensitive detection was achieved.	Water	10-15	nuclear RNA export factor 1	Homo sapiens	60-63
23327166-7	2013	The improvement in hydrophilicity of the PCL-knitted mesh was confirmed through water contact angle measurements, and penetration of the collagen into the mesh was evaluated by scanning electron microscopy (SEM).	Water	80-85	PHD finger protein 1	Homo sapiens	41-44
24386522-3	2013	An analytical electrolyte for tap water was used instead of an expensive acid or base ionic solution.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
23687970-0	2013	Water-soluble mmp-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier.	Water	0-5	matrix metallopeptidase 9	Homo sapiens	14-19
23687970-2	2013	The water-soluble prodrug ND-478 is hydrolyzed to the active MMP-9 inhibitor ND-322, which in turn is N-acetylated to the even more potent metabolite ND-364.	Water	4-9	matrix metallopeptidase 9	Homo sapiens	61-66
23692186-0	2013	Physiological mechanisms for the increase in renal solute-free water clearance by a glucagon-like peptide-1 mimetic.	Water	63-68	glucagon	Rattus norvegicus	84-107
23692186-1	2013	The aim of the present study was to clarify the mechanisms mediating the effect of a glucagon-like peptide-1 (GLP-1) mimetic on solute-free water excretion in rats.	Water	140-145	glucagon	Rattus norvegicus	85-108
23692186-1	2013	The aim of the present study was to clarify the mechanisms mediating the effect of a glucagon-like peptide-1 (GLP-1) mimetic on solute-free water excretion in rats.	Water	140-145	glucagon	Rattus norvegicus	110-115
35454631-8	2022	It can be predicted that the NUC-FM is an ideal filling grouting material for water-filled karst caves in shield tunnels in water-rich karst areas.	Water	78-83	Nuc	Drosophila melanogaster	29-32
23913976-6	2013	TSK-gel NH2 column showed mixed HILIC-ion-exchange mechanism, the highest separation efficiency and better selectivity and resolution for tested analytes than the other studied column, especially at concentration of water in mobile phase lower than 30 % (v/v).	Water	216-221	tsukushi, small leucine rich proteoglycan	Homo sapiens	0-3
35454631-8	2022	It can be predicted that the NUC-FM is an ideal filling grouting material for water-filled karst caves in shield tunnels in water-rich karst areas.	Water	124-129	Nuc	Drosophila melanogaster	29-32
35414062-4	2022	Here we present a new extensive sea level dataset that we have digitised from historical hand-written tabulated ledgers of high and low water, from the Port of London Authority (PLA).	Water	136-141	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	32-35
23927230-5	2013	Using the noise radiated by a distant ship and a single hydrophone, the proposed methodology allows estimating the waveguide invariant for each pair of modes in shallow water.	Water	169-174	inositol polyphosphate-5-phosphatase D	Homo sapiens	38-42
23735601-7	2013	Water sorption was highest in the Z250 and lowest in the P90.	Water	0-5	cellular inhibitor of PP2A	Homo sapiens	57-60
35437455-2	2022	Aquaporin-3 (AQP-3) belongs to the family of aquaporins and mainly transports water and other small molecular proteins, which is reduced with the aging of the intervertebral disc.	Water	78-83	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
23845376-0	2013	Re: glucocorticoid mediates water avoidance stress-sensitized colon-bladder cross-talk via RSK2/PSD-95/NR2B in rats.	Water	28-33	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	103-107
35437455-2	2022	Aquaporin-3 (AQP-3) belongs to the family of aquaporins and mainly transports water and other small molecular proteins, which is reduced with the aging of the intervertebral disc.	Water	78-83	aquaporin 3 (Gill blood group)	Homo sapiens	13-18
35442300-6	2022	Due to glacier melting, the intrusion of colder and lighter water into the ocean increases the stratification of the water column, influencing the sea-ice increase and reducing ocean-atmosphere exchanges, affecting the global water cycle.	Water	60-65	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	147-150
23887961-4	2013	Tap water was used as the amniotic fluid.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
35442300-6	2022	Due to glacier melting, the intrusion of colder and lighter water into the ocean increases the stratification of the water column, influencing the sea-ice increase and reducing ocean-atmosphere exchanges, affecting the global water cycle.	Water	117-122	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	147-150
35442300-6	2022	Due to glacier melting, the intrusion of colder and lighter water into the ocean increases the stratification of the water column, influencing the sea-ice increase and reducing ocean-atmosphere exchanges, affecting the global water cycle.	Water	226-231	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	147-150
34995399-3	2022	A systematic study shows that electron-donating oleylamine act as a shuttle ligand to transport MnX 2 through the water-hexane interface and deliver it to the NPls.	Water	114-119	keratin 86	Homo sapiens	96-99
23143012-7	2013	We conclude that AQP4 levels in CSF are elevated after TBI and it might serve as a useful biochemical marker to assess brain water metabolism in clinical settings.	Water	125-130	aquaporin 4	Homo sapiens	17-21
35456600-3	2022	Here we employed HME, FQC, and CP to generate saSMSDs containing the water-insoluble BCS II drug nitrendipine (NIT) and self-micellizing polymer Soluplus .	Water	69-74	ceruloplasmin	Homo sapiens	31-33
23656428-7	2013	GhBCP2 (a blue copper-binding protein) inhibited GhPIP2;6 water channel activity through their interaction.	Water	58-63	lamin-like protein	Gossypium hirsutum	0-6
23673351-7	2013	Functional assays (using heterologous expression in Xenopus laevis oocytes) of ZmTIP2;2 and ZmPIP2;8 confirmed that these aquaporins demonstrate water channel capacity.	Water	145-150	aquaporin PIP1-5	Zea mays	92-100
25093018-4	2013	With a +38 net charge in water, tropoelastin molecules provide extraordinary elasticity and selective interactions with cell surface integrins.	Water	25-30	elastin	Homo sapiens	32-44
35454100-8	2022	We addressed this question through molecular dynamics simulations approaches and managed to demonstrate a direct interaction between AQP2 and dexamethasone and its significant impact on the channel water permeability.	Water	198-203	aquaporin 2	Homo sapiens	133-137
28811451-1	2013	A novel Ca(II) coordination polymer, [CaL(4,4"-bipyridyl)(H2O)4]n (L = 1,6-naphthalenedisulfonate), was synthesized by reaction of calcium perchlorate with 1,6-naphthalenedisulfonic acid disodium salt and 4,4"-bipyridyl in CH3CH2OH/H2O.	Water	58-61	carbonic anhydrase 2	Homo sapiens	8-13
28811451-4	2013	The geometry of the Ca(II) ion is a distorted CaNO6 pengonal bipyramid, arising from its coordination by four water molecules, one nitrogen atom of 4,4"-bipyridyl molecule, and two oxygen atoms from two L ligands.	Water	110-115	carbonic anhydrase 2	Homo sapiens	20-26
23622518-0	2013	Effect of chlorpyrifos on the inhibition of the enzyme acetylcholinesterase by cross-linking in water-supply samples and milk from dairy cattle.	Water	96-101	acetylcholinesterase	Bos taurus	55-75
35454100-9	2022	Through compartmentalization of sodium and potassium ions, a significant effect of Na+ upon AQP2 water permeability was highlighted as well.	Water	97-102	aquaporin 2	Homo sapiens	92-96
23947871-0	2013	On the state of water in 2.4 nm cylindrical pores of MCM from dynamic and normal specific heat studies.	Water	16-21	methylmalonyl-CoA mutase	Homo sapiens	53-56
35104599-5	2022	The result indicates that the nucleation rate of MET-HCl in water was highest among four solvents.	Water	60-65	SAFB like transcription modulator	Homo sapiens	49-52
23950863-2	2013	The water channel protein, Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis in the central nervous system and has recently been reported with cell survival except for its well-known function in brain edema.	Water	4-9	aquaporin 4	Homo sapiens	27-38
23950863-2	2013	The water channel protein, Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis in the central nervous system and has recently been reported with cell survival except for its well-known function in brain edema.	Water	4-9	aquaporin 4	Homo sapiens	40-44
24478935-5	2013	In this project, we first built a chemical structure based searchable database for 85 FDA approved chemotherapy drugs and then used Bio-Rad"s KnowItAll  Informatics suite to focus on the drugs pH-dependent water solubility prediction.	Water	206-211	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	136-139
23790991-0	2013	Sociodemographic characteristics and beverage intake of children who drink tap water.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
23790991-1	2013	BACKGROUND: Tap water provides a calorie-free, no-cost, environmentally friendly beverage option, yet only some youth drink it.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
35448102-8	2022	The filtration loss performance of low-cost CMCS can reach the standards of LV-CMC and CMS of the specification of water-based drilling fluid materials in petroleum industry.	Water	115-120	G protein signaling modulator 2	Homo sapiens	44-48
23623843-1	2013	This study was designed to investigate chemical characterization of the water-soluble polysaccharides extracted from Keemun black tea (KBTP), and their antioxidant and hepatoprotective effects against CCl4-induced oxidative damage in mice.	Water	72-77	chemokine (C-C motif) ligand 4	Mus musculus	201-205
23686284-1	2013	Twenty cocaine-water complexes were studied using density functional theory (DFT) B3LYP/6-311++G** level to understand their geometries, energies, vibrational frequencies, charge transfer and topological parameters.	Water	15-20	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	84-87
35391343-1	2022	nov., a new shallow-water octocoral (Cnidaria, Anthozoa) from southwestern Atlantic, and implications on the systematics of the genus.	Water	20-25	cellular communication network factor 3	Homo sapiens	0-4
23808529-1	2013	Dye sensitization of zinc oxide single crystals by a carbazole thiophene cyanoacrylate (MK-2) sensitizer deposited from THF and mixtures of THF and water was investigated.	Water	148-153	MAPK activated protein kinase 2	Homo sapiens	88-92
23790991-2	2013	PURPOSE: To examine sociodemographic characteristics, weight status, and beverage intake of those aged 1-19 years who drink tap water.	Water	128-133	nuclear RNA export factor 1	Homo sapiens	124-127
23790991-3	2013	METHODS: National Health and Nutrition Examination Survey data (2005-2010) were used to examine factors associated with tap water consumption.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
23790991-5	2013	RESULTS: Tap water consumption was more prevalent among school-aged children (OR=1.85, 95% CI=1.47, 2.33, for those aged 6-11 years; OR=1.85, 95% CI=1.32, 2.59, for those aged 12-19 years) as compared to those aged 1-2 years.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
23790991-7	2013	Tap water consumers drank more fluid (52.5 vs 48.0 ounces, p&lt;0.01); more plain water (20.1 vs 15.2 ounces, p&lt;0.01); and less juice (3.6 vs 5.2 ounces, p&lt;0.01) than nonconsumers.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
23790991-7	2013	Tap water consumers drank more fluid (52.5 vs 48.0 ounces, p&lt;0.01); more plain water (20.1 vs 15.2 ounces, p&lt;0.01); and less juice (3.6 vs 5.2 ounces, p&lt;0.01) than nonconsumers.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	0-3
35294991-5	2022	The maximum amount of HT that could be dispersed in water was much higher for the encapsulated form (99+-7 mug mL-1 ) than the non-encapsulated form (<10 mug mL-1 ).	Water	52-57	L1 cell adhesion molecule	Mus musculus	111-115
23702591-0	2013	Bacterial community of iron tubercles from a drinking water distribution system and its occurrence in stagnant tap water.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
23702591-3	2013	Comparison of the bacterial community composition of pipe tubercles with that of stagnant tap water samples based on a denaturing gradient gel electrophoresis analysis of the 16S rRNA gene revealed that the communities were related.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
23702591-8	2013	Inorganic contaminants at low levels, including Al, Mn, Zn, Pb, Cr, Cu, and Ni, were detected in tubercles and were concentrated in particulates from tap water following the release of iron during stagnation.	Water	154-159	nuclear RNA export factor 1	Homo sapiens	150-153
23566919-2	2013	A microsyringe is used to withdrew and discharge 10-12muL of the extraction solvent and 60-120muL of water as the dispersed solvent (containing 1mgL(-1), Tween 80) 4 times within 10s to form a cloudy emulsified solution in the syringe.	Water	101-106	LLGL scribble cell polarity complex component 1	Homo sapiens	145-151
23862950-3	2013	In this paper, we show calculations of the frequency spectrum for light and heavy water at room temperature using two flexible point charge potentials: SPC-MPG and TIP4P/2005f.	Water	82-87	N-methylpurine DNA glycosylase	Homo sapiens	156-159
35368305-5	2022	Mice lacking c-Rel displayed anxiety and depressive-like behavior starting in the premotor phase at 12 months, as indicated by the analysis with the open field (OF) test and the forced swim test with water wheel (FST), respectively.	Water	200-205	reticuloendotheliosis oncogene	Mus musculus	13-18
23861848-1	2013	Aquaporin-4 (AQP4) is the primary cellular water channel in the brain and is abundantly expressed by astrocytes along the blood-brain barrier and brain-cerebrospinal fluid interfaces.	Water	43-48	aquaporin 4	Mus musculus	0-11
23321855-8	2013	In households with tap water As &lt;=10 p.p.b., over 93% of total arsenic exposure was attributable to diet.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
35104250-2	2022	We previously discovered that GRP170 regulates the degradation and assembly of the epithelial sodium channel (ENaC), which reabsorbs sodium in the distal nephron and thereby regulates salt-water homeostasis and blood pressure.	Water	189-194	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	110-114
23822255-0	2013	Finite-size scaling investigation of the liquid-liquid critical point in ST2 water and its stability with respect to crystallization.	Water	77-82	ST2	Homo sapiens	73-76
23822255-2	2013	The hypothesis originates from computer simulations of the ST2 water model, but the stability of the LDL phase with respect to the crystal is still being debated.	Water	63-68	ST2	Homo sapiens	59-62
23822255-3	2013	We simulate supercooled ST2 water at constant pressure, constant temperature, and constant number of molecules N for N &lt;= 729 and times up to 1 mus.	Water	28-33	ST2	Homo sapiens	24-27
23861848-1	2013	Aquaporin-4 (AQP4) is the primary cellular water channel in the brain and is abundantly expressed by astrocytes along the blood-brain barrier and brain-cerebrospinal fluid interfaces.	Water	43-48	aquaporin 4	Mus musculus	13-17
23861848-2	2013	Water transport via AQP4 contributes to the activity-dependent volume changes of the extracellular space (ECS), which affect extracellular solute concentrations and neuronal excitability.	Water	0-5	aquaporin 4	Mus musculus	20-24
23861848-10	2013	This study reveals that water transport through AQP4 channels enhances and accelerates astrocyte swelling.	Water	24-29	aquaporin 4	Mus musculus	48-52
23665928-0	2013	Pharmaceuticals in tap water: human health risk assessment and proposed monitoring framework in China.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
23665928-1	2013	BACKGROUND: Pharmaceuticals are known to contaminate tap water worldwide, but the relevant human health risks have not been assessed in China.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
23665928-2	2013	OBJECTIVES: We monitored 32 pharmaceuticals in Chinese tap water and evaluated the life-long human health risks of exposure in order to provide information for future prioritization and risk management.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
35309430-2	2022	The solubility of MET HCl in water, water + N,N-dimethylformamide, water + acetonitrile, and water + n-propanol was measured by the gravimetric method under atmospheric pressure at temperatures ranging from 283.15 to 323.15 K. The solubility of MET HCl has a positive correlation with temperature and water content.	Water	301-306	SAFB like transcription modulator	Homo sapiens	18-21
23665928-9	2013	CONCLUSION: Chinese tap water is an additional route of human exposure to pharmaceuticals, particularly for dimetridazole, although the risk to human health is low based on current toxicity data.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
23713661-3	2013	The ethyl acetate, methanolic, and water extracts of Ajwa dates, active at 250 mug/mL in the MTT assay, inhibited lipid peroxidation (LPO) by 88, 70, and 91% at 250 mug/mL and cyclooxygenase enzymes COX-1 by 30, 31, and 32% and COX-2 by 59, 48, and 45% at 100 mug/mL, respectively.	Water	35-40	cytochrome c oxidase subunit 1	Phoenix dactylifera	199-204
24067460-0	2013	Sulphurous thermal water increases the release of the anti-inflammatory cytokine IL-10 and modulates antioxidant enzyme activity.	Water	19-24	interleukin 10	Homo sapiens	81-86
23713661-3	2013	The ethyl acetate, methanolic, and water extracts of Ajwa dates, active at 250 mug/mL in the MTT assay, inhibited lipid peroxidation (LPO) by 88, 70, and 91% at 250 mug/mL and cyclooxygenase enzymes COX-1 by 30, 31, and 32% and COX-2 by 59, 48, and 45% at 100 mug/mL, respectively.	Water	35-40	cytochrome c oxidase subunit 2	Phoenix dactylifera	228-233
34982299-0	2022	Deep Sea Water Alleviates Tau Phosphorylation and Cognitive Impairment via PI3K/Akt/GSK-3beta Pathway.	Water	9-14	microtubule associated protein tau	Homo sapiens	26-29
23688053-8	2013	After water evaporation, the PIL solution has excess H(+) and reduced conductivity, which is still significantly higher than that of pure BMIBF4.	Water	6-11	serpin family A member 2 (gene/pseudogene)	Homo sapiens	29-32
23931090-6	2013	GCL/GCP, in either water or 10% ethanol vehicles, increased the skin penetration and skin deposition of MAP in comparison with GC, hydroxypropylmethylcellulose, and carbopol, while sustaining its release from the polymer gels.	Water	19-24	germ cell-less 2, spermatogenesis associated	Homo sapiens	0-3
23688053-10	2013	DFT calculations assist the interpretation of the vibrational spectroscopy and show that the remaining water is in the form of H3O(+) solvated by the IL molecular ions.	Water	103-108	H3 clustered histone 15	Homo sapiens	127-130
35199170-1	2022	Macroalgae and seagrasses in coastal habitats are exposed to turbulent water currents and waves that deform them and can rip them off the substratum, but that also transport essential water-borne substances to them and disperse their propagules and wastes.	Water	71-76	receptor interacting serine/threonine kinase 1	Homo sapiens	121-124
23416254-4	2013	In this study, we provide molecular-level information for the interaction of SEPT2 with Langmuir monolayers at the air/water interface, which are used as simplified membrane models.	Water	119-124	septin 2	Homo sapiens	77-82
23732306-3	2013	The MD simulation study of several solvated X-ray structures of apo and holo TTR has indicated the role of a conserved water molecule and its interaction with T4 binding residues Ser117 and Thr119.	Water	119-124	transthyretin	Homo sapiens	77-80
35222966-7	2022	Moreover, glutathione-s-transferase activated in late July when the sea water temperature was exceptionally high and Acartia sp.	Water	72-77	glutathione S-transferase kappa 1	Homo sapiens	10-35
23853479-7	2013	The tap water was the only common exposure of the patients.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
23853479-12	2013	It is presumed that the tap water was contaminated by a sewage leak from the aged pipelines.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
24672765-4	2013	The results of simulation were validated by measurements in water by ionization chamber and extended dose range (EDR2) film in solid water.	Water	133-138	polyhomeotic homolog 2	Homo sapiens	113-117
23416254-7	2013	Most importantly, in situ polarization-modulated infrared reflection absorption spectroscopy results indicated that the native secondary structure of SEPT2 is preserved upon interacting with PtdIns(4,5)P2, but not when dipalmitoylphosphatidylcholine is at the air/water interface.	Water	264-269	septin 2	Homo sapiens	150-155
35205186-1	2022	The Aeolian Islands (Mediterranean Sea) host a unique hydrothermal system called the "Smoking Land" due to the presence of over 200 volcanic CO2-vents, resulting in water acidification phenomena and the creation of an acidified benthic environment.	Water	165-170	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	35-38
23247129-3	2013	STZ increased daily water intake and decreased visceral (spleen and pancreas) weight in mice; sEH inhibition in STZ mice decreased water intake, but did not affect visceral weight.	Water	131-136	epoxide hydrolase 2, cytoplasmic	Mus musculus	94-97
35129359-0	2022	C7N6/Sc2CCl2 Weak van der Waals Heterostructure: A Promising Visible-Light-Driven Z-Scheme Water Splitting Photocatalyst with Interface Ultrafast Carrier Recombination.	Water	91-96	C-C motif chemokine ligand 2	Homo sapiens	8-12
23802977-1	2013	At low coverage of water on Cu(110), substrate-mediated electrostatics lead to zigzagging chains along [001] as observed with STM [T. Yamada, S. Tamamori, H. Okuyama, and T. Aruga, "Anisotropic water chain growth on Cu(110) observed with scanning tunneling microscopy" Phys.	Water	19-24	sulfotransferase family 1A member 3	Homo sapiens	126-129
23802977-1	2013	At low coverage of water on Cu(110), substrate-mediated electrostatics lead to zigzagging chains along [001] as observed with STM [T. Yamada, S. Tamamori, H. Okuyama, and T. Aruga, "Anisotropic water chain growth on Cu(110) observed with scanning tunneling microscopy" Phys.	Water	194-199	sulfotransferase family 1A member 3	Homo sapiens	126-129
35129359-2	2022	Here, based on extensive first-principles calculations combined with excited state dynamics simulations, we report that a weak van der Waals (vdW) C7N6/Sc2CCl2 heterostructure is a mediator-free direct Z-scheme photocatalyst for solar water splitting.	Water	235-240	C-C motif chemokine ligand 2	Homo sapiens	155-159
35108721-3	2022	With the aid of a coordination-driven self-assembly strategy, a new nonporous 2D CuII coordination network, (Cu2L(H2O)2)n (donated as CuCP), based on H4L, where H4L = 4-(4-(3,5-di-carboxy-pyridin-4-yl)phenyl)pyridine-2,6-dicarboxylic acid, was afforded hydrothermally.	Water	114-117	H4 clustered histone 7	Homo sapiens	150-153
23782914-10	2013	In general, tap water represented 60% of drinking water volume whereas bottled water represented 40%.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
23782914-12	2013	Plain water consumption (bottled and tap) tended to be associated with higher incomes.	Water	6-11	nuclear RNA export factor 1	Homo sapiens	37-40
23684468-7	2013	Finally, the system was applied to an extended automated analysis of Hobart Southern Water tap water for a period of 48 h. The overall repeatability of the migration times of a 14 analyte standard sample was less than 0.74% under laboratory conditions.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	91-94
23684468-7	2013	Finally, the system was applied to an extended automated analysis of Hobart Southern Water tap water for a period of 48 h. The overall repeatability of the migration times of a 14 analyte standard sample was less than 0.74% under laboratory conditions.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
35108721-3	2022	With the aid of a coordination-driven self-assembly strategy, a new nonporous 2D CuII coordination network, (Cu2L(H2O)2)n (donated as CuCP), based on H4L, where H4L = 4-(4-(3,5-di-carboxy-pyridin-4-yl)phenyl)pyridine-2,6-dicarboxylic acid, was afforded hydrothermally.	Water	114-117	H4 clustered histone 7	Homo sapiens	161-164
35072187-1	2022	A berkelium(III) mellitate, Bk2(C6(CO2)6)(H2O)8 2H2O, was synthesized and rapidly crystallized by reacting mellitic acid, C6(CO2H)6, and BkBr3 nH2O in an aqueous medium.	Water	42-45	bradykinin receptor B2	Homo sapiens	28-31
23468340-7	2013	The mean recoveries of C48/80 from spiked samples ranged between 98.1% and 105.9% for calibration curves done with the blank matrices and between 89.3% and 103.3% for calibration curves done with water, respectively.	Water	196-201	CDK5 regulatory subunit associated protein 2	Homo sapiens	23-26
35187314-0	2022	Experimental Investigation into Flue Gas Water and Waste Heat Recovery Using a Purge Gas Ceramic Membrane Condenser.	Water	41-46	gastrin	Homo sapiens	37-40
23511059-7	2013	Compared with GA3 technical, the conjugate had better water solubility and stability and have potential applications.	Water	54-59	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	14-17
35187314-0	2022	Experimental Investigation into Flue Gas Water and Waste Heat Recovery Using a Purge Gas Ceramic Membrane Condenser.	Water	41-46	gastrin	Homo sapiens	85-88
35187314-1	2022	The direct discharge of wet saturated flue gas from a coal-fired power plant boiler causes a lot of water and waste heat loss.	Water	100-105	gastrin	Homo sapiens	43-46
35187314-2	2022	An inorganic ceramic membrane condenser recovers water and waste heat from the flue gas, which has great significance to improve energy utilization efficiency and reduce water consumption.	Water	49-54	gastrin	Homo sapiens	84-87
23534970-3	2013	In this work, TiO2-CNF composite films were fabricated and evaluated for photocatalytic activity under UV light and their potential to remove organic compounds from water.	Water	165-170	NPHS1 adhesion molecule, nephrin	Homo sapiens	19-22
35187314-2	2022	An inorganic ceramic membrane condenser recovers water and waste heat from the flue gas, which has great significance to improve energy utilization efficiency and reduce water consumption.	Water	170-175	gastrin	Homo sapiens	84-87
35187314-5	2022	Based on the above ideas, a purge gas ceramic membrane condenser experimental platform was built for the water and waste heat recovery from the flue gas, and the water and waste heat recovery characteristics and the purge gas outlet parameters were discussed.	Water	105-110	gastrin	Homo sapiens	34-37
35187314-5	2022	Based on the above ideas, a purge gas ceramic membrane condenser experimental platform was built for the water and waste heat recovery from the flue gas, and the water and waste heat recovery characteristics and the purge gas outlet parameters were discussed.	Water	105-110	gastrin	Homo sapiens	149-152
23468162-6	2013	The present findings demonstrate that simultaneous electrospinning technique for PCL with water-soluble PVP provides important insights for successful tuning biodegradation rate for the PCL electrospun scaffolds but not limited to expand other high valuable biocompatible polymers for the future biomedical applications, ranging from tissue regeneration to controlled drug delivery.	Water	90-95	PHD finger protein 1	Homo sapiens	186-189
35187314-5	2022	Based on the above ideas, a purge gas ceramic membrane condenser experimental platform was built for the water and waste heat recovery from the flue gas, and the water and waste heat recovery characteristics and the purge gas outlet parameters were discussed.	Water	162-167	gastrin	Homo sapiens	34-37
35187314-7	2022	The experimental results show that the water and waste heat recovery characteristics are enhanced with the purge gas flow increases.	Water	39-44	gastrin	Homo sapiens	113-116
35187314-8	2022	Increasing the flue gas temperature will increase the water recovery rate and heat recovery power.	Water	54-59	gastrin	Homo sapiens	20-23
23862497-1	2013	Steam CO2 reforming of methane was investigated over Ni-based perovskite catalyst to produce desired H2/CO ratio by adjusting the feed ratio of CH4, CO2 and H2O for floating GTL process application.	Water	157-160	relaxin 2	Homo sapiens	101-106
35187314-10	2022	The purge gas absorbs the water and waste heat from the flue gas, the purge gas temperature and moisture content are significantly increased, and the purge gas relative humidity is also close to saturation.	Water	26-31	gastrin	Homo sapiens	10-13
35187314-10	2022	The purge gas absorbs the water and waste heat from the flue gas, the purge gas temperature and moisture content are significantly increased, and the purge gas relative humidity is also close to saturation.	Water	26-31	gastrin	Homo sapiens	61-64
35187314-10	2022	The purge gas absorbs the water and waste heat from the flue gas, the purge gas temperature and moisture content are significantly increased, and the purge gas relative humidity is also close to saturation.	Water	26-31	gastrin	Homo sapiens	76-79
34951432-4	2022	Due to the presence of RP, BP, ZnFe2O4 and the cell membrane, the M-RP/BP@ZnFe2O4 NSs exhibited high performance in cancer phototherapy with the following features: (i) a Z-scheme heterojunction structure was formed between RP/BP NSs thus enabling high separation efficiency of the photogenerated electrons and holes; (ii) the photoexcitation holes in the valence band of RP can break the tumor microenvironment by oxidizing glutathione; (iii) the NSs could decompose water to produce H2O2 and O2, which can be further converted to toxic  OH through the ZnFe2O4 catalyzed Fenton reaction and 1O2 through energy transfer, respectively; and (iv) the cell membrane wrapping improved the targeting of the composite NSs at the tumor site and photonic therapy can be finally triggered by a 660 nm laser to convert O2 to  O2- and 1O2.	Water	468-473	growth differentiation factor 5	Mus musculus	27-29
24259835-0	2013	Carbon Dioxide Water Bathing Enhances Myogenin but Not MyoD Protein Expression after Skeletal Muscle Injury.	Water	15-20	myogenin	Rattus norvegicus	38-46
24259835-6	2013	Tap water and CO2 (1,000 ppm) water bathing were performed at 37  C for 30 minutes once a day.	Water	4-9	SEC14-like lipid binding 2	Rattus norvegicus	0-3
23822365-1	2013	Novel double pulse forming lines (PFLs) are fabricated with two separate coaxial single PFLs with the same dimensions with each inner cylinder of the PFL negatively charged to improve the breakdown voltage of PFL and the energy storage density of de-ionized water.	Water	258-263	profilin 2	Homo sapiens	34-37
23822365-3	2013	Ethylene glycol is mixed with de-ionized water to raise the leakage resistance and the impedance of the single PFL.	Water	41-46	profilin 2	Homo sapiens	111-114
35498975-3	2022	The water-soluble extract (WSE) of meat crust was hydrolysed by protease A (PA) and treated with glutaminase (GA).	Water	4-9	glutaminase	Homo sapiens	97-108
34935845-4	2022	Herein, we report the synthesis of HA nanoparticles coordinated by citric acid (Cit/HA) based on the interactions between carboxylate and calcium ions to control the sizes and shapes of the hybrid nanoparticles, to improve their dispersibility in water and to eventually form uniform transparent films with nanospaces, and investigated the film formation mechanism.	Water	247-252	citron rho-interacting serine/threonine kinase	Homo sapiens	80-83
23600693-8	2013	Here we investigate the magnitude of the instantaneous charge transfer through calculating the fast one electron reduction energies of AnO2(H2O)n(2+), where An = U, Np, and Pu, for n = 4-6, in solution without inclusion of the structural optimization energy of the reduced form.	Water	140-143	anoctamin 2	Homo sapiens	135-139
23600693-10	2013	The results obtained for calculated electron affinities in the aqueous phase for the AnO2(H2O)5(2+/+) couples are within 0.04 V of accepted experimental redox potentials, nearly an order of magnitude improvement on previous calculated standard potentials E(0) values, obtained using both DFT and high level multireference approaches.	Water	90-93	anoctamin 2	Homo sapiens	85-89
35207427-4	2022	We show that an alternative approach, grounded in the magnitude of the solvent-excluded volume effect and its temperature dependence (strictly linked to the translational entropy of solvent and co-solute molecules), is able to rationalize the occurrence of ELP collapse in water on raising the temperature, as well as the T(collapse) lowering caused by the addition to water of either TMAO, glycine, or betaine.	Water	273-278	nuclear receptor subfamily 5 group A member 1	Homo sapiens	257-260
23642004-6	2013	In the case of activated esters, the process can also be viewed as water autoionization with formation of hydroxide ion aided by a second water molecule acting as a general base (W(AI)B mechanism).	Water	67-72	ANIB1	Homo sapiens	181-185
23642004-6	2013	In the case of activated esters, the process can also be viewed as water autoionization with formation of hydroxide ion aided by a second water molecule acting as a general base (W(AI)B mechanism).	Water	138-143	ANIB1	Homo sapiens	181-185
35207427-4	2022	We show that an alternative approach, grounded in the magnitude of the solvent-excluded volume effect and its temperature dependence (strictly linked to the translational entropy of solvent and co-solute molecules), is able to rationalize the occurrence of ELP collapse in water on raising the temperature, as well as the T(collapse) lowering caused by the addition to water of either TMAO, glycine, or betaine.	Water	369-374	nuclear receptor subfamily 5 group A member 1	Homo sapiens	257-260
35054947-1	2022	The cAMP-dependent aquaporin-2 (AQP2) redistribution from intracellular vesicles into the plasma membrane of renal collecting duct principal cells induces water reabsorption and fine-tunes body water homeostasis.	Water	155-160	aquaporin 2	Rattus norvegicus	32-36
24416558-6	2013	EDR 2 film was exposed with nine 6 cm x 6 cm fields of 6 MV photon beam obtained from a medical linear accelerator at 5-cm depth in solid water phantom.	Water	138-143	polyhomeotic homolog 2	Homo sapiens	0-5
35054947-1	2022	The cAMP-dependent aquaporin-2 (AQP2) redistribution from intracellular vesicles into the plasma membrane of renal collecting duct principal cells induces water reabsorption and fine-tunes body water homeostasis.	Water	194-199	aquaporin 2	Rattus norvegicus	32-36
23643041-6	2013	The water solubility of TO dye was increased in the presence of calixarene sulfonate, and further protein labeling experiments suggested that this TO-SCA6 complex can act as a fluorescent probe for labeling of biomolecules.	Water	4-9	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	150-154
35087537-7	2021	Drinking the DSS-supplementing water also increased disease activity index (DAI) and serum urea nitrogen level (P <0.05), shortened colonic length (P <0.05), impaired colonic enterocyte apoptosis, cell cycle, and the ZO-1 mRNA expression (P <0.05), increased the ratio of CD11c-, CD64-, and CD169-positive cells in colon (P <0.05), and induced extensive ulcer, infiltration of inflammatory cells, and collagenous fiber hyperplasia in colon.	Water	31-36	sialic acid binding Ig like lectin 1	Homo sapiens	291-296
23737238-0	2013	ClogP(alk): a method for predicting alkane/water partition coefficient.	Water	43-48	ALK receptor tyrosine kinase	Homo sapiens	6-9
23737238-1	2013	Alkane/water partition coefficients (P(alk)) are less familiar to the molecular design community than their 1-octanol/water equivalents and access to both data and prediction tools is much more limited.	Water	7-12	ALK receptor tyrosine kinase	Homo sapiens	39-42
35057468-11	2022	Compared to the LS1 and LS2 groups, the HS2 group had 310-381, 250-358 and 382-655 mL more amounts of water from the total water intake (TWI), total drinking fluids and water from food (all p < 0.05), respectively.	Water	102-107	spectrin beta, erythrocytic	Homo sapiens	40-43
23737238-3	2013	The basis for the ClogP(alk) model is the strong (R2 = 0.987) relationship between alkane/water partition coefficient and molecular surface area (MSA) that was observed for saturated hydrocarbons.	Water	90-95	ALK receptor tyrosine kinase	Homo sapiens	24-27
23737238-7	2013	The ClogP(alk) model was parameterized using data measured for structurally prototypical compounds that dominate the literature on alkane/water partition coefficients and then validated using an external test set of 100 alkane/water logP measurements, the majority of which were for drugs.	Water	138-143	ALK receptor tyrosine kinase	Homo sapiens	10-13
23737238-7	2013	The ClogP(alk) model was parameterized using data measured for structurally prototypical compounds that dominate the literature on alkane/water partition coefficients and then validated using an external test set of 100 alkane/water logP measurements, the majority of which were for drugs.	Water	227-232	ALK receptor tyrosine kinase	Homo sapiens	10-13
35057468-11	2022	Compared to the LS1 and LS2 groups, the HS2 group had 310-381, 250-358 and 382-655 mL more amounts of water from the total water intake (TWI), total drinking fluids and water from food (all p < 0.05), respectively.	Water	123-128	spectrin beta, erythrocytic	Homo sapiens	40-43
35057468-11	2022	Compared to the LS1 and LS2 groups, the HS2 group had 310-381, 250-358 and 382-655 mL more amounts of water from the total water intake (TWI), total drinking fluids and water from food (all p < 0.05), respectively.	Water	169-174	spectrin beta, erythrocytic	Homo sapiens	40-43
23239271-3	2013	In the current study, molecular dynamics simulations are employed at different Asp181 protonation states and initial positions of active site water molecules, and compared with the existing crystallographic data of PTP1B.	Water	142-147	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	215-220
35057468-12	2022	Participants in the HS2 group had 384-403, 129-228 and 81-114 mL more in the water, water from dishes and staple foods, respectively, than those in the groups of LS1 and LS2 (p < 0.05).	Water	77-82	spectrin beta, erythrocytic	Homo sapiens	20-23
23500055-6	2013	In addition, when the rats were exposed to forced cold water swimming stress during adulthood, SYN expression (CA3 and DG regions) and Apo levels (CA3 region) in rat hippocampus showed statistical difference between early restraint stress group and non-early restraint stress group (rats exposed to stress in adulthood only).	Water	55-60	synaptophysin	Rattus norvegicus	95-98
35057468-12	2022	Participants in the HS2 group had 384-403, 129-228 and 81-114 mL more in the water, water from dishes and staple foods, respectively, than those in the groups of LS1 and LS2 (p < 0.05).	Water	84-89	spectrin beta, erythrocytic	Homo sapiens	20-23
23500055-6	2013	In addition, when the rats were exposed to forced cold water swimming stress during adulthood, SYN expression (CA3 and DG regions) and Apo levels (CA3 region) in rat hippocampus showed statistical difference between early restraint stress group and non-early restraint stress group (rats exposed to stress in adulthood only).	Water	55-60	carbonic anhydrase 3	Rattus norvegicus	111-114
23051109-8	2013	CONCLUSIONS: With the clinical use of a helmet, for patient comfort and mucosal humidification during CPAP, the most desirable conditions are likely to be obtained by humidifying without heating, that is by leaving the water in the humidifier chamber at room temperature.	Water	219-224	centromere protein J	Homo sapiens	102-106
34989519-8	2022	There was a significant correlation between lg Koc and lg Kd (P<0.05), indicating that the organic carbon plays an important role in the distribution of the target PPCPs in water and sediments.	Water	173-178	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	47-50
23544659-1	2013	Coupled cluster [CCSD(T)] theory and density functional theory (DFT) have been used to study the production of H2 and O2 from hydrolysis products generated from H2O addition to (MO2)n (M = Ti, Zr, Hf, n = 1-3) clusters on both the lowest singlet and triplet potential energy surfaces (PESs).	Water	161-164	relaxin 2	Homo sapiens	111-120
23528166-7	2013	Subsequently, the beta-elimination of the C5 proton utilizes as base an OH(-) derived from a conserved crystal water that is part of a proton wire water channel, and this syn beta-elimination reaction is the rate-limiting step.	Water	111-116	synemin	Homo sapiens	171-174
23528423-0	2013	Dynamics of uncrystallized water and protein in hydrated elastin studied by thermal and dielectric techniques.	Water	27-32	elastin	Homo sapiens	57-64
23528166-7	2013	Subsequently, the beta-elimination of the C5 proton utilizes as base an OH(-) derived from a conserved crystal water that is part of a proton wire water channel, and this syn beta-elimination reaction is the rate-limiting step.	Water	147-152	synemin	Homo sapiens	171-174
35057045-1	2022	Oral solid dosage forms that contain APIs in the amorphous state have become commonplace because of many drug substances exhibiting poor water solubility, which negatively impacts their absorption in the human GI tract.	Water	137-142	G protein subunit alpha i1	Homo sapiens	210-212
23637886-5	2013	We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT cells.	Water	16-19	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	141-146
23627709-6	2013	Our findings indicated that Abeta rats made significantly more errors in the radial arm water maze (RAWM) compared to all other groups and exhibited suppressed E-LTP in area CA1, which correlated with deleterious alterations in the levels of memory and E-LTP-related signaling molecules including calcineurin (PP2B), brain derivedneurotrophic factor (BDNF) and phosphorylated CaMKII (p-CaMKII).	Water	88-93	amyloid beta precursor protein	Rattus norvegicus	28-33
34983480-20	2022	CONCLUSION: These results show that QAF water extract effectively prevents skin photoaging by enhancing collagen deposition and inhibiting MMP-1 via the ERK/AP-1 signaling pathway.	Water	40-45	matrix metallopeptidase 1	Homo sapiens	139-144
23330917-6	2013	AccA gene abundances correlated with archaeal amoA gene abundance throughout the water column (r(2)  = 0.309, P &lt; 0.0001).	Water	81-86	acetyl-CoA carboxylase alpha	Homo sapiens	0-4
23687491-2	2013	Although the pathophysiology of PPH remains unknown, some treatments, including topical aluminum chloride (AC) and tap water iontophoresis (TWI), are effective at suppressing the perspiration.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
2532586-1	1989	The spa treatment most widely used in the management of renal calculosis is the drinking of a certain amount of mineral water under certain predetermined conditions of temperature, time and rhythm.	Water	120-125	surfactant protein A2	Homo sapiens	4-7
23580524-6	2013	An upper limit is obtained for the reaction of syn-CH3CHOO with water, and the rate constant for reaction of anti-CH3CHOO with water is measured as 1.0 x 10(-14) +- 0.4 x 10(-14) centimeter(3) second(-1).	Water	64-69	synemin	Homo sapiens	47-50
23580524-6	2013	An upper limit is obtained for the reaction of syn-CH3CHOO with water, and the rate constant for reaction of anti-CH3CHOO with water is measured as 1.0 x 10(-14) +- 0.4 x 10(-14) centimeter(3) second(-1).	Water	127-132	synemin	Homo sapiens	47-50
23348716-1	2013	Nanoaggregates of a supramolecular ensemble of triphenylene derivative 3 and Cu(2+) ions exhibit "turn-on" response towards CN(-) ions in an aqueous medium and can detect the trace amount of inorganic cyanide ions (NaCN) in tap water and blood serum milieu.	Water	228-233	nuclear RNA export factor 1	Homo sapiens	224-227
23322320-6	2013	AQP4 plays an important role in brain water homeostasis.	Water	38-43	aquaporin 4	Homo sapiens	0-4
22968856-1	2013	BACKGROUND: Vasopressin V1a receptor null (V1aR(-/-)) mice recently showed incomplete urinary concentration due to higher urine volume during control and water diuresis (euhydration), but showed normal response during dehydration (Aoyagi et al., Am J Physiol 295: F100-7, 2008).	Water	154-159	arginine vasopressin receptor 1A	Mus musculus	12-36
22968856-1	2013	BACKGROUND: Vasopressin V1a receptor null (V1aR(-/-)) mice recently showed incomplete urinary concentration due to higher urine volume during control and water diuresis (euhydration), but showed normal response during dehydration (Aoyagi et al., Am J Physiol 295: F100-7, 2008).	Water	154-159	arginine vasopressin receptor 1A	Mus musculus	43-47
23346911-3	2013	During brain activation, release of ions and metabolites from endfeet is anticipated to increase perivascular fluid osmolarity, AQP4-mediated osmotic water flow from endfeet, and metabolite washout from brain.	Water	150-155	aquaporin 4	Mus musculus	128-132
23346911-8	2013	The results suggest a role for AQP4-mediated water flow in support of washout of metabolites, and underscore the need for greater understanding of astrocytic water and metabolite fluxes.	Water	45-50	aquaporin 4	Mus musculus	31-35
23305757-9	2013	In contrast, tap water use in households was a protective factor against any helminth infection (i.e. T. trichiura OR=0.6, 95% CI 0.4-0.9).	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
22906896-10	2013	CONCLUSIONS: This new method of Boussignac CPAP humidification yielded humidity values above 25 mg H2O/L regardless of the heated humidifier and flow used.	Water	99-102	centromere protein J	Homo sapiens	43-47
23521793-2	2013	In most NMO patients, autoantibodies to the water channel protein Aquaporin 4 (AQP4) are present at high levels and are thought to drive pathology by mediating complement-dependent destruction of astrocytes.	Water	44-49	aquaporin 4	Homo sapiens	79-83
23409805-0	2013	Large-scale solid-state synthesis of Sn-SnO2 nanoparticles from layered SnO by sunlight: a material for dye degradation in water by photocatalytic reaction.	Water	123-128	strawberry notch homolog 2	Homo sapiens	40-43
23514985-0	2013	Incidence of hot tap water scalds after the introduction of regulations in Ontario.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
23514985-7	2013	There were a total of 6952 hot tap water scald cases in Ontario, including 408 hospitalizations in the 8-year period.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
23193539-2	2013	It was used successfully for the amperometric detection of iodide in aqueous solution and tap water after a pre-concentration step, with a detection limit of 1.5 x 10(-7) M. This electrode has an excellent stability.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
23129587-10	2013	The combination of H(2)O(2) and leukotriene B(4) (LTB(4)) increased intracellular Ca(2+) concentration and their adhesion to endothelial cells in Trpm2(+)(/+) but not in Trpm2(-/-)PMNs.	Water	19-24	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	146-151
23129587-10	2013	The combination of H(2)O(2) and leukotriene B(4) (LTB(4)) increased intracellular Ca(2+) concentration and their adhesion to endothelial cells in Trpm2(+)(/+) but not in Trpm2(-/-)PMNs.	Water	19-24	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	170-175
21794921-10	2013	Meanwhile, a three-week test of using polycarbonate bottles and ceramic cups to drink bottled water and boiled tap-water was carried out among 12 graduate students of 25 years old.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
22544071-0	2013	Analysis of elemental concentration using ICP-AES and pathogen indicator in drinking water of Qasim Abad, District Rawalpindi, Pakistan.	Water	85-90	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	100-104
22544071-8	2013	The total number of coliforms present in water samples was found to be within the prescribed limit of the WHO except for 5 out of 11 bore water samples (B-2, B-3, B-4, B-8, B-11), which were found in the range 5-35 MPN/100 mL, a consequence of infiltration of contaminated water (sewage) through cross connection, leakage points and back siphoning.	Water	138-143	immunoglobulin kappa variable 5-2	Homo sapiens	153-177
22544071-8	2013	The total number of coliforms present in water samples was found to be within the prescribed limit of the WHO except for 5 out of 11 bore water samples (B-2, B-3, B-4, B-8, B-11), which were found in the range 5-35 MPN/100 mL, a consequence of infiltration of contaminated water (sewage) through cross connection, leakage points and back siphoning.	Water	138-143	immunoglobulin kappa variable 5-2	Homo sapiens	153-177
23268839-5	2013	The transient gene expression analysis and the transient RNA interference (RNAi) test in protoplasts showed that ZmCPK11 is involved in ABA-induced up-regulation of the expression and the activities of superoxide dismutase (SOD) and ascorbate peroxidase (APX), and in the production of H(2)O(2).	Water	286-291	superoxide dismutase	Zea mays	202-222
23268839-5	2013	The transient gene expression analysis and the transient RNA interference (RNAi) test in protoplasts showed that ZmCPK11 is involved in ABA-induced up-regulation of the expression and the activities of superoxide dismutase (SOD) and ascorbate peroxidase (APX), and in the production of H(2)O(2).	Water	286-291	APx1-Cytosolic Ascorbate Peroxidase	Zea mays	233-253
22986031-5	2013	Glycerin diluted with tap water followed by a tap water flush is our preferred irrigation protocol.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
22986031-9	2013	Patients using glycerin instilled a median of 30 ml (mean 29) glycerin and 50 ml (131) tap water.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
23262184-9	2013	The knockdown AtCysA1 mutant did not differ from wild-type while AtCysC1 mutants were slightly more sensitive to water deficit.	Water	113-118	cysteine synthase C1	Arabidopsis thaliana	65-72
23200507-0	2013	Influence of minerals on the taste of bottled and tap water: a chemometric approach.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
23200507-8	2013	The preferred bottled and tap water samples were associated with moderate (relatively to the parameters mean values) contents of total dissolved solids and with relatively high concentrations of HCO3-, SO42-, Ca2+ and Mg2+ as well as with relatively high pH values.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
23273631-9	2013	The method was applied to the analysis of thirteen water samples from Tianjin, China, including wastewater, tap water, surface water, and groundwater.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	108-111
23277579-0	2013	Protective role of brain water channel AQP4 in murine cerebral malaria.	Water	25-30	aquaporin 4	Mus musculus	39-43
23277579-3	2013	Expression and cellular localization of the brain water channel aquaporin-4 (AQP4) was investigated during the neurological syndrome.	Water	50-55	aquaporin 4	Mus musculus	77-81
23215152-0	2013	Water networks in fast proton transfer during catalysis by human carbonic anhydrase II.	Water	0-5	carbonic anhydrase 2	Homo sapiens	65-86
23215152-1	2013	Variants of human carbonic anhydrase II (HCA II) with amino acid replacements at residues in contact with water molecules in the active-site cavity have provided insights into the proton transfer rates in this protein environment.	Water	106-111	carbonic anhydrase 2	Homo sapiens	18-39
23199337-6	2013	The use of water not only avoided the scavenging of reactive radicals by organic solvent but also enhanced the adsorption of BDE209 on the surface of TiO(2), both of which favor the contact of BDE209 with photogenerated holes and  OH species.	Water	11-16	homeobox D13	Homo sapiens	125-128
24334980-7	2013	Spike tests with 2 mug (10 mug L(-1)) of DPAA, PAA, and iAs in 200 mL of tap water and bottled drinking water showed good recoveries (96.1-103.8%).	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
24069842-10	2013	However, tap water in some areas also seems to have a high content of endotoxin, and this too should be considered when deliberating the protection of the airways of workers.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
23041070-9	2013	In the recovery experiment model, where mice were treated with 3% DSS for four days and water for three days, Vdr(DeltaIEpC) mice showed a high score of IBD symptoms; severe damage of mucosal layer and increased expression of genes encoding proinflammatory cytokines.	Water	88-93	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	110-113
24429828-2	2013	GN and UGN (guanylin peptides) induce secretion of electrolytes and water in both intestine and kidney.	Water	68-73	guanylate cyclase activator 2B	Homo sapiens	7-10
22789782-4	2013	The results were discussed in terms of the distribution of relaxation frequencies and the activation energy for the conduction and polarization mechanisms particularly in the elastin-water and collagen-water systems.	Water	183-188	elastin	Rattus norvegicus	175-182
22796779-4	2013	The Pt-SnO(2)@C nanocomposite modified glassy carbon (GC) electrode exhibited enhanced amperometric response to H(2)O(2), with detection limit of 0.1 muM and sensitivity of 241.1 muA mM(-1) cm(-2).	Water	112-117	strawberry notch homolog 2	Homo sapiens	7-10
24069046-0	2013	Potential Osteoporosis Recovery by Deep Sea Water through Bone Regeneration in SAMP8 Mice.	Water	44-49	sepia	Mus musculus	40-43
24069046-6	2013	Deep sea water-treated BMSCs showed stronger osteogenic differentiation such as BMP2, RUNX2, OPN, and OCN, and enhanced colony forming abilities, compared to the control group.	Water	9-14	sepia	Mus musculus	5-8
24072543-5	2013	Guidelines forWater Quality on Board Merchant Ships Including Passenger Vessels of Health Protection Agency, World Health Organisation (WHO) Guide to Ship Sanitation, WHO Guidelines for Drinking Water Quality, WHO Water Safety Plan and the United States Center for Disease Control and Prevention Vessel Sanitation Program were examined.	Water	14-19	inositol polyphosphate-5-phosphatase D	Homo sapiens	46-50
23544065-5	2013	By iteratively truncating a Jun-based peptide from 37 to 22 residues, strategically incorporating i i+4 helix-inducing constraints, and positioning unnatural amino acids, we have produced short, water-stable, alpha-helical peptides that bind cFos.	Water	195-200	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	242-246
23994849-2	2013	It was found out that Moscow tap water contains little fluoride, the difference between districts and okrugs is of no consequence.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
23520928-0	2013	[The effectiveness of the application of mineral water from the Klyuchi health resort in the programs of combined spa-based rehabilitation of the patients presenting with acquired jaw defects].	Water	49-54	surfactant protein A2	Homo sapiens	114-117
23270503-3	2012	Astrocytes express aquaporin 4, the water channel protein, involved in water homeostasis and edema formation.	Water	36-41	aquaporin 4	Homo sapiens	19-30
23258324-2	2012	The present study was aimed to observe the effects of intrahippocampal injection of Abeta31-35 on the spatial learning and memory of rats by using Morris water maze technique, and explore the neuroprotective effects and possible mechanism of [Gly14]-humanin (HNG) against Abeta-induced deficits in learning behavior.	Water	154-159	amyloid beta precursor protein	Rattus norvegicus	84-89
22980895-1	2012	Mineral, spring and tap water samples of different geographical origins (7 classes) were distinguished by various methods, such as sensory evaluation, electronic tongue measurement, inductively coupled plasma atomic emission spectroscopy and ion chromatography.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
23249007-2	2012	In the S(0) state of TRA(H(2)O)(1), a water molecule is hydrogen-bonded to the N atom of the amino group of a flexible ethylamine side chain [T. S. Zwier, J. Phys.	Water	38-43	T cell receptor alpha locus	Homo sapiens	21-24
23249007-6	2012	In the D(0) state of [TRA(H(2)O)(1)](+), the water molecule is hydrogen-bonded to the NH group of the indole ring of TRA(+), indicating that the water molecule transfers from the amino group to NH group.	Water	45-50	T cell receptor alpha locus	Homo sapiens	22-25
23249007-6	2012	In the D(0) state of [TRA(H(2)O)(1)](+), the water molecule is hydrogen-bonded to the NH group of the indole ring of TRA(+), indicating that the water molecule transfers from the amino group to NH group.	Water	45-50	T cell receptor alpha locus	Homo sapiens	117-120
23249007-6	2012	In the D(0) state of [TRA(H(2)O)(1)](+), the water molecule is hydrogen-bonded to the NH group of the indole ring of TRA(+), indicating that the water molecule transfers from the amino group to NH group.	Water	145-150	T cell receptor alpha locus	Homo sapiens	22-25
23249007-6	2012	In the D(0) state of [TRA(H(2)O)(1)](+), the water molecule is hydrogen-bonded to the NH group of the indole ring of TRA(+), indicating that the water molecule transfers from the amino group to NH group.	Water	145-150	T cell receptor alpha locus	Homo sapiens	117-120
23249007-8	2012	Two potential energy barriers emerge in [TRA(H(2)O)(1)](+) along the intrinsic reaction coordinate of the water transfer.	Water	106-111	T cell receptor alpha locus	Homo sapiens	41-44
23249007-9	2012	The water transfer event observed in [TRA(H(2)O)(1)](+) is not an elementary but a complex process.	Water	4-9	T cell receptor alpha locus	Homo sapiens	38-41
23227925-8	2012	Antioxidant (EUK-8) and p38 MAPK inhibitor (SB202190) treatment attenuated the increase in caspase-3 activity, cell death and WDR35 expression induced by bupivacaine or H(2)O(2).	Water	169-174	caspase 3	Mus musculus	91-100
23231900-8	2012	The LIBS spectra  of tap water were recorded using the pre-concentration method and are discussed in comparison with the results from inductively coupled plasma atomic emission spectroscopy (ICP-AES).	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
23231900-9	2012	We could observe strong emission lines of Ca, Mg, K, Cu, and Sr in the tap water, of which concentrations were  determined to be 6.3, 1.3, 1.1, 0.64, and 0.046 ppm, respectively, by ICP-AES.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
22884469-3	2012	In this work we have determined the number and location of the transmembrane domains of the highly hydrophobic hepatitis C virus NS4B protein by studying the water-to-bilayer and water-to-interface transfer free energies of thirty-one different hepatitis C virus strains assuming that NS4B forms an alpha-helical wheel.	Water	179-184	polyprotein;protein F	Hepatitis C virus genotype 1	129-133
23241465-6	2012	RESULTS: Following an order to boil water, 87.5% of respondents refrained from drinking unboiled tap water.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	97-100
22827527-0	2012	Selective up-regulation of JunD transcript and protein expression in vasopressinergic supraoptic nucleus neurones in water-deprived rats.	Water	117-122	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-31
23127521-4	2012	H-86 variety Kashi Vishesh) when subjected to water withdrawal for 7, 14 and 21 days revealed significant and consistent changes in activities of enzymes SOD, CAT, APX, GR and POD paralleled with an increased proline levels.	Water	46-51	cytosolic ascorbate peroxidase 2	Solanum lycopersicum	164-167
23021792-6	2012	Ground and tap water samples analyzed were also contaminated with pharmaceuticals.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
23040562-0	2012	Comparison of the rates of phenol advanced oxidation in deionized and tap water within a dielectric barrier discharge reactor.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
23040562-3	2012	Interestingly, a significant rate increase was found in tap with respect to milliQ water.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	56-59
23040562-5	2012	The same increase in efficiency as observed in tap water was instead obtained when phenol was treated in solutions containing bicarbonate anions in the same concentration as present in tap water, an effect attributed to buffering of the solution pH.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
23040562-5	2012	The same increase in efficiency as observed in tap water was instead obtained when phenol was treated in solutions containing bicarbonate anions in the same concentration as present in tap water, an effect attributed to buffering of the solution pH.	Water	189-194	nuclear RNA export factor 1	Homo sapiens	47-50
23040562-5	2012	The same increase in efficiency as observed in tap water was instead obtained when phenol was treated in solutions containing bicarbonate anions in the same concentration as present in tap water, an effect attributed to buffering of the solution pH.	Water	189-194	nuclear RNA export factor 1	Homo sapiens	185-188
23047762-1	2012	The reaction of CoBr(2), 1,2-di(4H-1,2,4-triazol-4-yl)diazene (bta) and KSCN yielded a one-dimensional coordination polymer [Co(SCN)(2)(bta)(H(2)O)(2)] with water molecules coordinated to the metal ions.	Water	157-162	sorcin	Homo sapiens	73-76
23176729-3	2012	Residual ethanolamine was subsequently quantified by absorbance at 420 nm after reaction with 2,4,6-trinitrobenzenesulfonic acid (TNBS) at pH 9.2 for 15 min at 55 C followed by cooling with tap water.	Water	194-199	nuclear RNA export factor 1	Homo sapiens	190-193
23075091-6	2012	Using mutant proteins of GB1, we show again the generality of the powerful probe tryptophan for protein hydration (solvation) and the slowdown of the hydration layer dynamics especially at the water-protein interface.	Water	193-198	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	25-28
22944202-9	2012	A quantitative microbial risk assessment (QMRA) model with Monte Carlo simulations adopted by the World Health Organization (WHO) found the use of tap water and treated wastewater to be associated with risks that exceed permissible limits as proposed by the WHO (1.0 x 10(-3) disease risk per person per year) for the accidental ingestion of irrigated soil by farmers (Crete: 0.67 pppy and Italy: 1.0 pppy).	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
23078372-2	2012	Our data demonstrate that Co(9) is a homogeneous catalyst for water oxidation.	Water	62-67	phosphoserine phosphatase pseudogene 1	Homo sapiens	26-31
23078372-3	2012	Catalytic water electrolysis on fluorine-doped tin oxide coated glass electrodes occurs at reasonable low overpotentials and rates when Co(9) is present in a sodium phosphate buffer solution at neutral pH.	Water	10-15	phosphoserine phosphatase pseudogene 1	Homo sapiens	136-141
23078372-6	2012	Co(9) is also an extremely robust catalyst for chemical water oxidation.	Water	56-61	phosphoserine phosphatase pseudogene 1	Homo sapiens	0-5
22805349-5	2012	In both the experiments, treated animals were exposed to a 10% ethanol solution as the single drinking source for 4 weeks, while untreated animals were exposed to tap water over the same period.	Water	167-172	nuclear RNA export factor 1	Homo sapiens	163-166
23229609-2	2012	An optimal water treatment system includes tap water pretreatment and a double reverse osmosis process.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	43-46
22728640-1	2012	In this paper, the composition and biological activities of polysaccharides from Inula britannica flower IBP obtained by water extraction were investigated.	Water	121-126	trafficking protein particle complex 9	Mus musculus	105-108
22527777-4	2012	The Abeta-infused rats manifested remarkably increased escape latency and significantly decreased proportions of time and pathway crossing the hidden platform as compared to the rats in the pseudo-injection group and the non-injection group in Morris water maze test implicating the damaging effect of soluble Abeta oligomers on rat learning and memory functions.	Water	251-256	amyloid beta precursor protein	Rattus norvegicus	4-9
22297087-11	2012	After rinsing with tap water, the YM decreased to 95% of the fresh condition value (377.4N/mm(2), SD 144.5N/mm(2), non-significant change from fresh).	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
23431766-1	2012	Solute-free water clearance increased by 186% in water loaded rats treated with glucagon-like peptide 1 compared to untreated group.	Water	12-17	glucagon	Rattus norvegicus	80-103
23431766-1	2012	Solute-free water clearance increased by 186% in water loaded rats treated with glucagon-like peptide 1 compared to untreated group.	Water	49-54	glucagon	Rattus norvegicus	80-103
23431766-4	2012	Administration of glucagon-like peptide 1 receptor antagonist to water loaded rats delayed (5 ml per 100 g bw) or prevented (2 ml per 100 g bw) increase in solute-free water clearance.	Water	65-70	glucagon-like peptide 1 receptor	Rattus norvegicus	18-50
23431766-4	2012	Administration of glucagon-like peptide 1 receptor antagonist to water loaded rats delayed (5 ml per 100 g bw) or prevented (2 ml per 100 g bw) increase in solute-free water clearance.	Water	168-173	glucagon-like peptide 1 receptor	Rattus norvegicus	18-50
23064864-8	2012	At the same time, out of 50, total aerobic mesophilic bacteria were isolated in 34 (68 %), fungi were isolated in 15 (30 %) and free living amoebae were isolated in 15 (30 %) domestic tap water samples.	Water	188-193	nuclear RNA export factor 1	Homo sapiens	184-187
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	153-159	carbonic anhydrase 2	Homo sapiens	124-130
22998407-8	2012	[Co(II)MST(OH(2))](-) was oxidized to form [Co(III)MST(OH(2))] that was further converted to [Co(III)MST(mu-OH)Ca(II) 15-crown-5](+) ([Co(III)(mu-OH)Ca(II)](+)) in the presence of base and Ca(II)OTf(2)/15-crown-5.	Water	11-17	carbonic anhydrase 2	Homo sapiens	111-117
22998407-8	2012	[Co(II)MST(OH(2))](-) was oxidized to form [Co(III)MST(OH(2))] that was further converted to [Co(III)MST(mu-OH)Ca(II) 15-crown-5](+) ([Co(III)(mu-OH)Ca(II)](+)) in the presence of base and Ca(II)OTf(2)/15-crown-5.	Water	11-17	carbonic anhydrase 2	Homo sapiens	149-155
22998407-8	2012	[Co(II)MST(OH(2))](-) was oxidized to form [Co(III)MST(OH(2))] that was further converted to [Co(III)MST(mu-OH)Ca(II) 15-crown-5](+) ([Co(III)(mu-OH)Ca(II)](+)) in the presence of base and Ca(II)OTf(2)/15-crown-5.	Water	55-61	carbonic anhydrase 2	Homo sapiens	111-117
22998407-8	2012	[Co(II)MST(OH(2))](-) was oxidized to form [Co(III)MST(OH(2))] that was further converted to [Co(III)MST(mu-OH)Ca(II) 15-crown-5](+) ([Co(III)(mu-OH)Ca(II)](+)) in the presence of base and Ca(II)OTf(2)/15-crown-5.	Water	55-61	carbonic anhydrase 2	Homo sapiens	149-155
22936807-7	2012	Lymph node cells from mice treated with p28/p40 blocked adoptive transfer of EAU to naive syngeneic mice by immunopathogenic T cells and suppressive effects of p28/p40 derived in part from antagonizing STAT1 and STAT3 pathways induced by IL-27 and IL-6.	Water	77-80	B cell receptor associated protein 31	Mus musculus	40-43
22936807-7	2012	Lymph node cells from mice treated with p28/p40 blocked adoptive transfer of EAU to naive syngeneic mice by immunopathogenic T cells and suppressive effects of p28/p40 derived in part from antagonizing STAT1 and STAT3 pathways induced by IL-27 and IL-6.	Water	77-80	interleukin 12b	Mus musculus	44-47
22936807-8	2012	Interestingly, IL27p28 also suppressed EAU, but to a lesser extent than p28/p40.	Water	39-42	interleukin 27	Mus musculus	15-22
22936807-8	2012	Interestingly, IL27p28 also suppressed EAU, but to a lesser extent than p28/p40.	Water	39-42	B cell receptor associated protein 31	Mus musculus	19-22
22932782-5	2012	c-Fos was used to measure neuronal activation in the nucleus of the solitary tract and area postrema in response to intragastric infusions of water, sucrose, or Intralipid.	Water	142-147	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
22840474-6	2012	Common invertebrates in treated water and in tap water were Rotifera (&lt;1 mm) and nematode worms (Nematoda, &lt;2 mm).	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
22841594-3	2012	In this study, a natural zeolite from Queensland was examined for its potential to treat CSG water to remove sodium ions to lower SAR and reduce the pH value.	Water	93-98	sarcosine dehydrogenase	Homo sapiens	130-133
23202933-2	2012	An autoantibody (NMO IgG) against aquaporin-4 (AQP4), a water channel expressed on astrocytes is thought to be causative.	Water	56-61	aquaporin 4	Homo sapiens	47-51
22683765-4	2012	The present study first examined the effects of different levels of exposure (3 days, 1 and 2 weeks) to water immersion stress on intestinal mucin gene expression in rats, and then explored the mechanisms underlying the stress-induced decrease in the colonic Muc2 level.	Water	104-109	solute carrier family 13 member 2	Rattus norvegicus	141-146
23702803-3	2013	The results showed that the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and the ability to inhibit hydroxy radical and glutathione (GSH) content were significantly (p &lt; 0.05 or p &lt; 0.01) decreased in the 300, 600 and 900 mg/kg groups in comparison with those of the control group.	Water	149-164	probable phospholipid hydroperoxide glutathione peroxidase	Glycine max	89-111
23618141-3	2013	Thus, we built a flow-through calibration system containing tap water spiked with 56 organic micropollutants (alkylphenols and phenols, hormones, pesticides, pharmaceuticals, UV filter).	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
23618141-5	2013	Tap water micropollutant concentrations and additional parameters (temperature, pH, conductivity, dissolved organic carbon, flow velocities) were kept constant and controlled throughout the calibration experiment.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
23618152-2	2013	Municipal tap water was used instead of conventional phosphate buffer as blank solution to avoid phosphate pollution.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
23618152-3	2013	The background organic compounds in municipal tap water were taken into account and they were validated to result in negative deviation to accuracy.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
23618152-4	2013	The microbial endogenous respiration was experimentally validated to be sensitive to salt ionic strength, and municipal tap water as blank was thought to generate positive deviation to accuracy.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
23659378-1	2013	BACKGROUND: Aquaporin-4 (AQP4) is a water channel mainly located in the ventricular ependymal cells (brain-CSF barrier), the sub-ependymal glia, glia limitans and in end-feet of astrocytes in at the blood-brain barrier (BBB).	Water	36-41	aquaporin 4	Homo sapiens	12-23
23659378-1	2013	BACKGROUND: Aquaporin-4 (AQP4) is a water channel mainly located in the ventricular ependymal cells (brain-CSF barrier), the sub-ependymal glia, glia limitans and in end-feet of astrocytes in at the blood-brain barrier (BBB).	Water	36-41	aquaporin 4	Homo sapiens	25-29
23517334-0	2013	Highly sensitive strategy for Hg2+ detection in environmental water samples using long lifetime fluorescence quantum dots and gold nanoparticles.	Water	62-67	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	30-33
23566077-2	2013	A technical solution has been used to reduce NCl3 exposure to acceptable levels, by adding a stripping step to the water recycling loop.	Water	115-120	calpain 5	Homo sapiens	45-49
23633596-5	2013	However, addition of GOL does affect the kinetics of CA II, presumably as it displaces the water proton-transfer network in the active site.	Water	91-96	carbonic anhydrase 2	Homo sapiens	53-58
23466090-6	2013	The half-life time of thiram 2mgL(-1) in Milli-Q water was 28min.	Water	49-54	LLGL scribble cell polarity complex component 1	Homo sapiens	30-36
23606429-6	2013	Consistent with its superior relaxivity measured by NMR, the rHDL-associated apoA-I containing the Gd[MTS-ADO3A] probe attached to position 55 displays favorable dynamic and water accessibility properties as determined by X-band EPR.	Water	174-179	apolipoprotein A-I	Mus musculus	77-83
23182244-2	2013	Here we show that intracerebroventricular injection of Abeta-containing water-soluble extracts of AD brain inhibits consolidation of the memory of avoidance learning in the rat and that this effect is highly dependent on the interval between learning and administration.	Water	72-77	amyloid beta precursor protein	Rattus norvegicus	55-60
24967239-3	2013	After ingestion of a salty meal, GN and UGN are secreted into the intestinal lumen, where they inhibit sodium absorption and induce anion and water secretion.	Water	142-147	guanylate cyclase activator 2a (guanylin)	Mus musculus	33-35
23376428-6	2013	The calculations reveal significant membrane thinning and water penetration due to the specific local polar environment produced by the charged K288 of TM7 in LeuT, that is membrane-facing deep inside the hydrophobic milieu of the membrane.	Water	58-63	Leucine transport, high	Homo sapiens	159-163
22968229-7	2013	We conclude that prolonged contact with lead plumbing can increase the lead content in tap water with subsequent increase in lead burden in infant fed formula and infant blood.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
22968229-10	2013	Capsule: Prolonged contact with lead plumbing can increase the lead content in tap water with subsequent increase in lead burden in infant fed formula and infant blood.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
23755765-4	2013	A statistically significant difference between spa water-treated lesions and placebo-treated lesions in the same patients was demonstrated for histopathologic and immunohistochemical parameters.	Water	51-56	surfactant protein A2	Homo sapiens	47-50
23403616-3	2013	NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells.	Water	25-30	CD44 molecule (Indian blood group)	Homo sapiens	79-83
23433550-8	2013	Notably, the X-gal tracer easily permeated into the Cldn1(-/-) SC, and water evaporation through isolated Cldn1(-/-) SC sheets was significantly higher than that through Cldn1(+/+) SC sheets.	Water	71-76	claudin 1	Mus musculus	106-111
23433550-8	2013	Notably, the X-gal tracer easily permeated into the Cldn1(-/-) SC, and water evaporation through isolated Cldn1(-/-) SC sheets was significantly higher than that through Cldn1(+/+) SC sheets.	Water	71-76	claudin 1	Mus musculus	106-111
23232865-4	2013	The first solvation shell of Ca(II) is formed by six water molecules, while the second shell contains five.	Water	53-58	carbonic anhydrase 2	Homo sapiens	29-35
23408641-11	2013	Tap water, seawater, and river water samples were successfully analyzed for the existence of CPs using the proposed method and satisfactory results were obtained.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
22936334-8	2013	Within the water group BDNF resting and post-CPET concentrations (p&lt;0.05) showed a significant increase and NGF tended to increase after the training intervention.	Water	11-16	brain derived neurotrophic factor	Homo sapiens	23-27
23481483-2	2013	AQP4 is the principal member of this protein family in the CNS, where it is expressed in astrocytes and is involved in water movement, cell migration and neuroexcitation.	Water	119-124	aquaporin 4	Homo sapiens	0-4
23610601-6	2013	A significant decrease of the LPL mRNA expression level was shown in primary fractions (Fr) 5 (36.2% decrease) and 6 (30.5% decrease) of the Cca water extracts.	Water	145-150	lipoprotein lipase	Mus musculus	30-33
24159533-5	2013	RESULTS: To prevent typhoid fever in the community, it is necessary to provide clean tap water service to 35.5% of the population, with an individual requiring 173 L of clean water daily.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
23420130-0	2013	Highly water-soluble platinum(II) complexes as GLUT substrates for targeted therapy: improved anticancer efficacy and transporter-mediated cytotoxic properties.	Water	7-12	solute carrier family 2 member 1	Homo sapiens	47-51
23555172-7	2013	RESULTS: By univariate analysis, the variables predictive of UC included feeling stress, light and heavy alcoholic drinking, spicy food, sugar consumption and infectious diarrhea, while heavy tea intake and tap water consumption were protective against UC.	Water	211-216	nuclear RNA export factor 1	Homo sapiens	207-210
23510408-7	2013	Based on the results of the multivariate analysis, consumption of tap water was the only statistically significant independent risk factor of gastroenteritis (RR = 2.34, 95% C.I.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
23487766-2	2013	AOX is a diiron carboxylate protein that catalyzes the four-electron reduction of dioxygen to water by ubiquinol.	Water	94-99	acyl-CoA oxidase 1	Homo sapiens	0-3
23364529-4	2013	We found that the maintenance of whole-body osmolality in seawater embryos was impaired by the knockdown of BNP+OLGC7 (BNP receptor) or CNP3 alone from 1 day postfertilization, and the CNP3 knockdown was accompanied by greater water loss.	Water	61-66	natriuretic peptides B	Oryzias latipes	108-111
23364529-4	2013	We found that the maintenance of whole-body osmolality in seawater embryos was impaired by the knockdown of BNP+OLGC7 (BNP receptor) or CNP3 alone from 1 day postfertilization, and the CNP3 knockdown was accompanied by greater water loss.	Water	61-66	natriuretic peptides B	Oryzias latipes	119-122
23364529-7	2013	We also found that the exaggerated water loss in CNP3 knockdown embryos is related to the failure to suppress aquaporin (AQP3, AQP4, and AQP9) gene expression.	Water	35-40	C-type natriuretic peptide 3	Oryzias latipes	49-53
23364529-8	2013	These results show that CNP3 decrease water permeability of body surfaces and that both BNP and CNP3 ensure sufficient blood flow to the yolk-sac membrane for efficient salt excretion by ionocytes and sufficient water production by yolk metabolism to promote seawater adaptation during early development in medaka.	Water	38-43	C-type natriuretic peptide 3	Oryzias latipes	24-28
23552011-2	2013	Tap water iontophoresis has long been known to inhibit sweat production.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
23552011-8	2013	In conclusion, tap water iontophoresis is a safe and effective treatment of palmar and plantar hyperhidrosis when used on Monday, Wednesday, and Friday for 4 weeks.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
23361354-6	2013	The change from distilled water to tap or simulated sea water results in a lower hydrogen evolution rate of about 50%.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	35-38
23448168-0	2013	Centrifugation-induced water-tunable photonic colloidal crystals with narrow diffraction bandwidth and highly sensitive detection of SCN-.	Water	23-28	sorcin	Homo sapiens	133-136
23448168-11	2013	The interaction between SCN(-) ions and DMAA repeat units is argued to block hydrogen bonds between DMAA and water molecules.	Water	109-114	sorcin	Homo sapiens	24-27
24003692-2	2013	Since "tthe middle of 2007 the concentration of chloroform and other TGM in tests of tap water were established to be defined at levels steadily below hygienic maximum concentration limits.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
23485542-0	2013	Rapid self-infusion of tap water.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
23485542-1	2013	Intravenous self-infusion of tap water has never been reported in the literature.&amp;nbsp; We present a 24-year-old healthy man who self-administered 2.5 L of tap water over 2 hours and developed acute illness including fever, change of mental status, acute hemolysis, low-grade disseminated intravascular coagulation, and acute kidney injury.&amp;nbsp;&amp;nbsp;	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
23485542-1	2013	Intravenous self-infusion of tap water has never been reported in the literature.&amp;nbsp; We present a 24-year-old healthy man who self-administered 2.5 L of tap water over 2 hours and developed acute illness including fever, change of mental status, acute hemolysis, low-grade disseminated intravascular coagulation, and acute kidney injury.&amp;nbsp;&amp;nbsp;	Water	33-38	nuclear RNA export factor 1	Homo sapiens	160-163
23485542-1	2013	Intravenous self-infusion of tap water has never been reported in the literature.&amp;nbsp; We present a 24-year-old healthy man who self-administered 2.5 L of tap water over 2 hours and developed acute illness including fever, change of mental status, acute hemolysis, low-grade disseminated intravascular coagulation, and acute kidney injury.&amp;nbsp;&amp;nbsp;	Water	164-169	nuclear RNA export factor 1	Homo sapiens	29-32
23485542-1	2013	Intravenous self-infusion of tap water has never been reported in the literature.&amp;nbsp; We present a 24-year-old healthy man who self-administered 2.5 L of tap water over 2 hours and developed acute illness including fever, change of mental status, acute hemolysis, low-grade disseminated intravascular coagulation, and acute kidney injury.&amp;nbsp;&amp;nbsp;	Water	164-169	nuclear RNA export factor 1	Homo sapiens	160-163
23188481-7	2013	Water sources such as tap, mobile stations (explained in a following section), and well water contributed to 24%, 14%, and 2% of an individual"s daily water consumption pattern, respectively.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	22-25
23188481-8	2013	Average daily potable water use of both bottled and tap water by individuals consisted of 65% drinking-water, while the remaining 35% was water used for preparing cold and hot beverages, such as, tea, coffee, and juices.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	52-55
23188481-8	2013	Average daily potable water use of both bottled and tap water by individuals consisted of 65% drinking-water, while the remaining 35% was water used for preparing cold and hot beverages, such as, tea, coffee, and juices.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
23188481-8	2013	Average daily potable water use of both bottled and tap water by individuals consisted of 65% drinking-water, while the remaining 35% was water used for preparing cold and hot beverages, such as, tea, coffee, and juices.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
23188481-8	2013	Average daily potable water use of both bottled and tap water by individuals consisted of 65% drinking-water, while the remaining 35% was water used for preparing cold and hot beverages, such as, tea, coffee, and juices.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
23188482-10	2013	Three food groups were negatively associated with urinary perchlorate: grain products for children; sugars, sweets, and beverages for adolescents; and home tap water for adults.	Water	160-165	nuclear RNA export factor 1	Homo sapiens	156-159
23188482-11	2013	In a separate model, however, perchlorate consumed via home tap water contributed significantly to adult urinary perchlorate: 2.11E-4 ng ClO(4)(-)/ml per ng perchlorate in tap water consumed.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
23188482-11	2013	In a separate model, however, perchlorate consumed via home tap water contributed significantly to adult urinary perchlorate: 2.11E-4 ng ClO(4)(-)/ml per ng perchlorate in tap water consumed.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	172-175
23188482-11	2013	In a separate model, however, perchlorate consumed via home tap water contributed significantly to adult urinary perchlorate: 2.11E-4 ng ClO(4)(-)/ml per ng perchlorate in tap water consumed.	Water	176-181	nuclear RNA export factor 1	Homo sapiens	172-175
23188482-12	2013	In a nationally representative sample of the United States 6-84 YO, diet and tap water contributed significantly to urinary perchlorate, with diet contributing substantially more than tap water.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
23188482-12	2013	In a nationally representative sample of the United States 6-84 YO, diet and tap water contributed significantly to urinary perchlorate, with diet contributing substantially more than tap water.	Water	188-193	nuclear RNA export factor 1	Homo sapiens	184-187
23427143-3	2013	Polycyclic aromatic hydrocarbons are well known for strong carcinogenicity and thus a severe concentration control is required for drinking water and/or river water, which is the main resource of tap water.	Water	140-145	nuclear RNA export factor 1	Homo sapiens	196-199
25427464-8	2013	Inverse gas chromatography (IGC) results showed that the hot water pre-extraction changed the active sites on the bagasse surface, decreasing the dispersive energy and the basicity character, and affected the particle morphology.	Water	61-66	alcohol dehydrogenase iron containing 1	Homo sapiens	57-60
23188258-7	2013	These results indicate that the reaction of water radiolysis products, presumably OH radicals, with the sugar-phosphate moieties in the DNA backbone induces both AP sites and SSB with similar efficiency.	Water	44-49	single-stranded DNA-binding protein	Escherichia coli	175-178
23274254-0	2013	A vibrational spectroscopic study of the phosphate mineral zanazziite - Ca2(MgFe2+)(MgFe2+Al)4Be4(PO4)6.6(H2O).	Water	106-109	carbonic anhydrase 2	Homo sapiens	72-75
23391895-6	2013	A majority of residents believed that dioxins can be found in river water that has been filtered to completely remove all particulates, well water, and even city tap water, beliefs which are incongruous with the hydrophobic nature of dioxins.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	162-165
23373464-2	2013	The present work accounts for the acidity determination of HCOOH, CH3COOH, and CH3CH2COOH in the alkylimidazolium-based protic ionic liquids (PILs), incorporated with carboxylate anion, water, and in a binary mixture of PIL and water using the Hammett acidity function, H0.	Water	186-191	serpin family A member 2 (gene/pseudogene)	Homo sapiens	142-145
23373464-2	2013	The present work accounts for the acidity determination of HCOOH, CH3COOH, and CH3CH2COOH in the alkylimidazolium-based protic ionic liquids (PILs), incorporated with carboxylate anion, water, and in a binary mixture of PIL and water using the Hammett acidity function, H0.	Water	228-233	serpin family A member 2 (gene/pseudogene)	Homo sapiens	142-145
23373464-4	2013	It was emphasized that an increased stabilization offered by PIL cation toward the more basic conjugate anion of organic acid was responsible for this anomalous change in acidity order in PILs, which was absent in water.	Water	214-219	serpin family A member 2 (gene/pseudogene)	Homo sapiens	61-64
22922080-0	2013	Developments in the synthesis of a water compatible molecularly imprinted polymer as artificial receptor for detection of 3-nitro-L-tyrosine in neurological diseases.	Water	35-40	thrombopoietin	Mus musculus	130-131
22922080-1	2013	A highly selective water compatible molecularly imprinted polymer (MIP) for 3-nitro-L-tyrosine (3NT), an oxidative stress marker associated with neurodegenerative disorders, was prepared and its use as solid-phase extraction (SPE) sorbent material was demonstrated.	Water	19-24	thrombopoietin	Mus musculus	84-85
23291172-4	2013	We show that the 5"-untranslated region of HSP70 messenger drives a hypertonicity-resistant translation (up to 0.425 osmol/kg of water), whereas cap-dependent protein synthesis is almost totally blocked under the same conditions.	Water	129-134	heat shock protein family A (Hsp70) member 4	Homo sapiens	43-48
22057895-2	2013	In adult mouse brain, inwardly rectifying K+ (Kir4.1) and aquaporin-4 (AQP4) channels localize to astroglial endfeets in contact with brain microvessels and glutamate synapses, optimizing clearance of extracellular K(+) and water from the synaptic layers.	Water	224-229	aquaporin 4	Mus musculus	58-69
22057895-2	2013	In adult mouse brain, inwardly rectifying K+ (Kir4.1) and aquaporin-4 (AQP4) channels localize to astroglial endfeets in contact with brain microvessels and glutamate synapses, optimizing clearance of extracellular K(+) and water from the synaptic layers.	Water	224-229	aquaporin 4	Mus musculus	71-75
22057895-9	2013	The time course and expression pattern suggests that Kir4.1 and AQP4 channels may play an important role in brain K(+) and water homeostasis in early postnatal weeks after birth and during aging.	Water	123-128	aquaporin 4	Mus musculus	64-68
22588193-8	2013	Our results suggest, according to the literature data, that SPA therapy with radioactive water could represent an alternative choice in chronic inflammatory diseases of the upper airways, nonresponsive to pharmacological therapy.	Water	89-94	surfactant protein A2	Homo sapiens	60-63
22906356-1	2013	The principal central nervous system (CNS) water channel, aquaporin-4 (AQP4), is confined to astrocytic and ependymal membranes and is the target of a pathogenic autoantibody, neuromyelitis optica (NMO)-IgG.	Water	43-48	aquaporin 4	Homo sapiens	58-69
22906356-1	2013	The principal central nervous system (CNS) water channel, aquaporin-4 (AQP4), is confined to astrocytic and ependymal membranes and is the target of a pathogenic autoantibody, neuromyelitis optica (NMO)-IgG.	Water	43-48	aquaporin 4	Homo sapiens	71-75
23167710-8	2013	CONCLUSIONS: This study successfully developed and tested a microarray-based assay that can specifically detect faecal indicator bacteria and human pathogens in tap water.	Water	165-170	nuclear RNA export factor 1	Homo sapiens	161-164
22497211-1	2013	AIMS: Aquaporin-4 (AQP4) is the most abundant cellular water channel in brain and could be a molecular basis for a cerebrospinal fluid absorption route additional to the arachnoid villi.	Water	55-60	aquaporin 4	Homo sapiens	6-17
22497211-1	2013	AIMS: Aquaporin-4 (AQP4) is the most abundant cellular water channel in brain and could be a molecular basis for a cerebrospinal fluid absorption route additional to the arachnoid villi.	Water	55-60	aquaporin 4	Homo sapiens	19-23
23697178-7	2013	This method was applied to the analysis of the surface water samples from the Dalian tap water and the Liaohe River estuary.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	85-88
23697178-7	2013	This method was applied to the analysis of the surface water samples from the Dalian tap water and the Liaohe River estuary.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
23312321-5	2013	The AMPAs could be determined in tap water with limits of detection of 0.01-0.07 mug L(-1) with the [M-H](-) ions extracted at an accuracy of +-5 mDa.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
23343283-0	2013	Free energy surface of ST2 water near the liquid-liquid phase transition.	Water	27-32	ST2	Homo sapiens	23-26
23343283-1	2013	We carry out umbrella sampling Monte Carlo simulations to evaluate the free energy surface of the ST2 model of water as a function of two order parameters, the density and a bond-orientational order parameter.	Water	111-116	ST2	Homo sapiens	98-101
23343283-5	2013	The pressure and temperature dependence of the shape of the free energy surface is consistent with the assignment of these two basins to the distinct low density and high density liquid phases previously predicted to occur in ST2 water.	Water	230-235	ST2	Homo sapiens	226-229
26589043-7	2013	Also, larger systems are still feasible on a standard cluster as demonstrated for H3O(+)(H2O)25Cl(-) with 80 atoms.	Water	89-92	H3 clustered histone 15	Homo sapiens	82-85
23165820-0	2013	Hot water-promoted S(N)1 solvolysis reactions of allylic and benzylic alcohols.	Water	4-9	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
23165820-2	2013	We have examined this remarkable difference in detail and found that hot water, whose behavior is quite different compared with room- or high-temperature water, could promote S(N)1 solvolysis reactions of allylic alcohols and thus caused the racemization of trans-(-)-sobrerol.	Water	73-78	alcohol dehydrogenase iron containing 1	Homo sapiens	69-72
23165820-4	2013	It was proposed that the catalytic effects of hot water are owing to its mild acidic characteristic, thermal activation, high ionizing power, and better solubility of organic reactant.	Water	50-55	alcohol dehydrogenase iron containing 1	Homo sapiens	46-49
23104561-1	2013	The Slc5a6 gene expresses a plasma membrane protein involved in the transport of the water-soluble vitamin biotin; the transporter is commonly referred to as the sodium-dependent multivitamin transporter (SMVT) because it also transports pantothenic acid and lipoic acid.	Water	85-90	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	Mus musculus	4-10
23104561-1	2013	The Slc5a6 gene expresses a plasma membrane protein involved in the transport of the water-soluble vitamin biotin; the transporter is commonly referred to as the sodium-dependent multivitamin transporter (SMVT) because it also transports pantothenic acid and lipoic acid.	Water	85-90	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	Mus musculus	162-203
23104561-1	2013	The Slc5a6 gene expresses a plasma membrane protein involved in the transport of the water-soluble vitamin biotin; the transporter is commonly referred to as the sodium-dependent multivitamin transporter (SMVT) because it also transports pantothenic acid and lipoic acid.	Water	85-90	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	Mus musculus	205-209
23186671-4	2013	The concentration of total organic carbon in the reactor discharge was very similar to the content of organic matter in tap water.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
22784207-1	2013	Oxytocin knockout (OT KO) mice acutely consume inappropriate amounts of sodium following overnight water deprivation suggesting that oxytocinergic neurons inhibit excessive sodium ingestion (Amico JA, Morris M, Vollmer RR.	Water	99-104	oxytocin	Mus musculus	0-8
23479768-1	2013	Guanylin (GN), uroguanylin (UGN) and the GC-C receptor have been associated with two endocrine axes: the salt and water homeostasis regulating enterorenal axis and the recently described appetite-regulating UGN/GC-C extraintestinal axis.	Water	114-119	guanylate cyclase activator 2a (guanylin)	Mus musculus	0-8
24640486-0	2013	The liquid-liquid transition in supercooled ST2 water: a comparison between umbrella sampling and well-tempered metadynamics.	Water	48-53	ST2	Homo sapiens	44-47
24640486-1	2013	We investigate the metastable phase behaviour of the ST2 water model under deeply supercooled conditions.	Water	57-62	ST2	Homo sapiens	53-56
23041323-12	2013	Water content in stool was lower (37%) in tgr5-ko than tgr5-tg (58%) or tgr5-wt mice (62%).	Water	0-5	G protein-coupled bile acid receptor 1	Mus musculus	42-46
23805697-1	2013	Due to intensive anthropogenic pollution of water environment generally accepted indicators of epidemic security of water bodies--common bacteria (CB) and thermotolerant coliform bacteria (TCB) do not always permit to obtain an objective characterization of bacterial contamination of tap water.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	285-288
23805697-3	2013	In monitoring for bacterial quality of tap water it is advisable to determine glucose positive coliform bacteria, that will provide the relevance of estimation of the epidemiological safety of water use.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
23805697-4	2013	According to the method developed by the authors the calculation of the index of population risk of acute intestinal infections (AHI) occurrence in dependence on the quality of tap water in Azov and Tsimlyansk towns.	Water	181-186	nuclear RNA export factor 1	Homo sapiens	177-180
23411707-2	2013	An autoantibody (NMO-IgG) targeting the aquaporin-4 water channel distinguishes NMO from other inflammatory disorders of the CNS.	Water	52-57	aquaporin 4	Homo sapiens	40-51
23476675-0	2013	The effect of different boiling and filtering devices on the concentration of disinfection by-products in tap water.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	106-109
23476675-2	2013	Filtering and boiling tap water can lead to changes in the DBP concentrations and modify the exposure through ingestion.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
23277478-0	2013	Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation.	Water	31-36	aquaporin 4	Mus musculus	0-11
23277478-3	2013	These effects could involve AQP4-dependent: (a) K(+) permeability, (b) resting ECS volume, (c) ECS contraction during K(+) reuptake, and (d) diffusion-limited water/K(+) transport coupling.	Water	159-164	aquaporin 4	Mus musculus	28-32
23277478-8	2013	The modeling thus provides a potential explanation for AQP4-dependent K(+)/water coupling in the ECS without requiring AQP4-dependent astrocyte K(+) permeability.	Water	75-80	aquaporin 4	Mus musculus	55-59
23277478-9	2013	Our model links the physical and ion/water transport properties of brain cells with the dynamics of neuroexcitation, and supports the conclusion that reduced AQP4-dependent water transport is responsible for defective neuroexcitation in AQP4 deficiency.	Water	37-42	aquaporin 4	Mus musculus	158-162
23277478-9	2013	Our model links the physical and ion/water transport properties of brain cells with the dynamics of neuroexcitation, and supports the conclusion that reduced AQP4-dependent water transport is responsible for defective neuroexcitation in AQP4 deficiency.	Water	173-178	aquaporin 4	Mus musculus	158-162
23231763-5	2013	Under drought conditions, mms21 mutants showed the highest survival rate and the slowest water loss, and accumulated a higher level of free proline compared to wild-type (WT) and MMS21 over-expression plants.	Water	89-94	RING/U-box superfamily protein	Arabidopsis thaliana	26-31
23053802-5	2013	The longer polypeptides (ELP2 and ELP4) also displayed higher specific dissipation values indicating that they established films with greater structural flexibility and associated water content than the shorter polypeptide, ELP1.	Water	180-185	elongator acetyltransferase complex subunit 2	Homo sapiens	25-29
22878862-1	2013	We present molecular modeling of the structure and possible proton transfer pathways from the surface of the protein to the zinc-bound water molecule in the active site of the mutant His-107-Tyr of human carbonic anhydrase II (HCAII).	Water	135-140	carbonic anhydrase 2	Homo sapiens	204-225
23382808-5	2013	Asn153 and Asp176 are directly coordinated with Ca3 and indirectly coordinated with Ca5 via a water molecule.	Water	94-99	carbonic anhydrase 5A	Homo sapiens	84-87
23382808-7	2013	Asp168 is the direct ligand for Ca5, and Ca5 coordination by Glu252 is mediated by two water molecules.	Water	87-92	carbonic anhydrase 5A	Homo sapiens	41-44
24171321-1	2013	Cytochrome c oxidase (COX) employs electrons obtained from cytochrome c to bring about the reduction of oxygen to water.	Water	114-119	cytochrome c oxidase subunit 7A1	Bos taurus	22-25
24185055-8	2013	This study showed the dissolution of nAg under various water conditions.	Water	55-60	NBAS subunit of NRZ tethering complex	Homo sapiens	37-40
23128290-5	2012	Among children in an urban slum, rate of diarrhea/1,000 child-days varied significantly by primary water source: 8.13 for tap water, 3.60 for bottled water, and 3.97 for water kiosks.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	122-125
23128290-6	2012	In multivariable Poisson regression analysis, diarrhea risk remained significantly lower among water kiosk users (adjusted rate ratio [RR] = 0.49, 95% confidence interval [CI] = 0.29-0.83) and bottled water users (adjusted RR = 0.45, 95% CI = 0.21-0.97), compared with tap water users.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	269-272
22270589-5	2012	This study showed that measured endotoxin concentrations in tap drinking water varied from 2.4 to 33.8 EU/ml with the average endotoxin concentration of 14.2 EU/ml.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	60-63
22270589-7	2012	The average concentration of endotoxin in bottled water is 13.5 % of the average concentration of endotoxin in tap drinking water.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	111-114
22270589-8	2012	This experimental investigation has proved that drinking bottled water has less endotoxin as compared to tap water in Kuwait.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	105-108
22987455-3	2012	(2012) Proc Natl Acad Sci USA 109:1245-1250) reported that NMO-IgG inhibits AQP4 water permeability directly and causes rapid cellular internalization of the M1 but not M23 isoform of AQP4, resulting in AQP4 clustering, enhanced complement-dependent cytotoxicity, and tissue swelling.	Water	81-86	aquaporin 4	Homo sapiens	76-80
22987455-5	2012	We measured osmotic water permeability by stopped-flow light scattering on plasma membrane vesicles isolated from AQP4-expressing CHO cells, an approach that can detect changes in water permeability as small as 5% and is not confounded by internalization effects.	Water	180-185	LOW QUALITY PROTEIN: aquaporin-4	Cricetulus griseus	114-118
22987455-6	2012	We found similar single-molecule water permeability for M1-AQP4 tetramers and M23-AQP4 clusters (orthogonal arrays of particles, OAPs).	Water	33-38	aquaporin 4	Homo sapiens	59-63
22939528-2	2012	These polymers self-assemble in water, without the need of any cosolvent, forming micelle-like aggregates that were imaged by TEM.	Water	32-37	MFT2	Homo sapiens	126-129
23082850-5	2012	There is evidence that AQP4 facilitates the removal of extracellular water following vasogenic edema.	Water	69-74	aquaporin 4	Homo sapiens	23-27
22814088-3	2012	Continuous drinking of oxygenated water markedly increased peripheral blood mononuclear cell proliferation, interleukin-1beta expression level and the CD4(+):CD8(+) cell ratio in pigs.	Water	34-39	CD4 molecule	Sus scrofa	151-154
22814088-4	2012	During Salmonella Typhimurium infection, total leukocytes and relative cytokines expression levels were significantly increased in pigs consuming oxygenated water compared with pigs consuming tap water.	Water	196-201	putative ABC-transporter	Sus scrofa	192-195
23113538-5	2012	The new Os-tpa complex acts as a very efficient turnover catalyst for syn-selective dihydroxylation of various alkenes (turnover number ~1000) in aqueous media, and H(2)O(2) oxidant is formally incorporated into the products quantitatively (100% atom efficiency).	Water	165-170	synemin	Homo sapiens	70-73
23058106-2	2012	Unconstrained rigid docking of benzimidazole ligands into representative CHK2 protein crystal structures reveals an alternative binding mode involving a water-mediated interaction with the hinge region; docking which incorporates protein side chain flexibility for selected residues in the ATP binding site resulted in a refinement of the water-mediated hinge binding mode that is consistent with observed SAR.	Water	153-158	sarcosine dehydrogenase	Homo sapiens	406-409
26605629-5	2012	The translational and rotational motions of the protein-bound spin label are considerably slowed compared to those of the free spin label in aqueous solution, but interestingly, hydrogen bonds formed between the nitroxide oxygen group and the surrounding water molecules are hardly affected by the presence of the amyloid protein.	Water	255-260	spindlin 1	Homo sapiens	62-66
26605629-5	2012	The translational and rotational motions of the protein-bound spin label are considerably slowed compared to those of the free spin label in aqueous solution, but interestingly, hydrogen bonds formed between the nitroxide oxygen group and the surrounding water molecules are hardly affected by the presence of the amyloid protein.	Water	255-260	spindlin 1	Homo sapiens	127-131
23090405-3	2012	In contrast, the biosynthesis of 2-methylisonorneol (2-MIB), which is responsible for taste and odour problems in drinking water, is unique in that it primes the enzymatic methylation of geranyl pyrophosphate (GPP) before cyclization, which is catalyzed by an S-adenosyl-L-methionine-dependent methyltransferase (GPPMT).	Water	123-128	MIB E3 ubiquitin protein ligase 1	Homo sapiens	55-58
22486562-5	2012	Incubation with pro-oxidants such as arachidonic acid (AA), beta-naphtoflavone, and H(2) O(2)  further enhanced KLF6(Full)  and its splice variants.	Water	84-90	Kruppel like factor 6	Homo sapiens	112-116
22930550-6	2012	These water molecules are reported to play a critical role in the catalytic reaction, highlighting a new area for inhibitor expansion within the limited architectural variation at the catalytic site of bacterial DHFR.	Water	6-11	Dihydrofolate reductase	Staphylococcus aureus	212-216
22837158-6	2012	The fourfold larger negative heat capacity derived for the interaction of P14 with H-2D(b) /gp33 compared with H-2D(b) /Y4A can possibly be explained by higher water entrapment at the TCR/MHC interface, which is also consistent with the measured opposite entropy contributions for the interactions of P14 with both MHCs.	Water	160-165	ribonuclease P/MRP subunit p14	Homo sapiens	74-77
22782669-2	2012	The polarized expression of the water channel protein aquaporin-4 (AQP4) on astroglial endfeet surrounding brain microvessels suggests a role in brain water balance.	Water	32-37	aquaporin 4	Mus musculus	54-65
22782669-2	2012	The polarized expression of the water channel protein aquaporin-4 (AQP4) on astroglial endfeet surrounding brain microvessels suggests a role in brain water balance.	Water	32-37	aquaporin 4	Mus musculus	67-71
23054308-0	2012	Dietary fibers solubilized in water or an oil emulsion induce satiation through CCK-mediated vagal signaling in mice.	Water	30-35	cholecystokinin	Mus musculus	80-83
23006249-2	2012	After the 2004 tsunami, the Red Cross distributed ceramic water filters in Sri Lanka.	Water	58-63	sorcin	Homo sapiens	75-78
23006249-13	2012	Tap water users also had higher-quality source water, suggesting that disuse is not necessarily negative and monitoring of water quality can aid decision-making about continued use.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
23006249-13	2012	Tap water users also had higher-quality source water, suggesting that disuse is not necessarily negative and monitoring of water quality can aid decision-making about continued use.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	0-3
23006249-13	2012	Tap water users also had higher-quality source water, suggesting that disuse is not necessarily negative and monitoring of water quality can aid decision-making about continued use.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	0-3
23692790-6	2012	Short binasal prongs were used in both groups and CPAP was set at the level of 5-6 cm H2O.	Water	86-89	centromere protein J	Homo sapiens	50-54
23115189-7	2012	The ROS-triggered transactivation of TrkB exerts neuroprotective effects, because inhibition of TrkB kinase activity or uncoupling Shc signaling from TrkB exacerbates neuronal cell death induced by H(2)O(2).	Water	198-203	SHC adaptor protein 1	Homo sapiens	131-134
22991937-4	2012	Water removal by membrane filtration produced CNF sheets filled with the particles.	Water	0-5	NPHS1 adhesion molecule, nephrin	Homo sapiens	46-49
23020306-5	2012	Samples of jam were extracted with water.	Water	35-40	F11 receptor	Homo sapiens	11-14
22900966-0	2012	Exploring the role of water molecules for docking and receptor guided 3D-QSAR analysis of naphthyridine derivatives as spleen tyrosine kinase (Syk) inhibitors.	Water	22-27	spleen associated tyrosine kinase	Homo sapiens	143-146
22900966-2	2012	The role of the water molecules was explored for the docking based alignment that revealed two conserved water molecules important for proper orientation and alignment of naphthyridine inhibitors in the active site of Syk enzyme.	Water	16-21	spleen associated tyrosine kinase	Homo sapiens	218-221
22900966-2	2012	The role of the water molecules was explored for the docking based alignment that revealed two conserved water molecules important for proper orientation and alignment of naphthyridine inhibitors in the active site of Syk enzyme.	Water	105-110	spleen associated tyrosine kinase	Homo sapiens	218-221
22794084-7	2012	In typical conditions, the use of public network water directly from the tap results in the best scenario, while if water is withdrawn from public fountains, its further transportation by private car can involve significant impacts.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	73-76
23061865-5	2012	In contrary, the denaturation of hairpin structure of GB1p peptide in GdmSCN/water solution is induced by the accumulation of Gdm(+) on protein surface and the hydrogen bonding from water as well as Gdm(+).	Water	77-82	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	54-58
23061865-5	2012	In contrary, the denaturation of hairpin structure of GB1p peptide in GdmSCN/water solution is induced by the accumulation of Gdm(+) on protein surface and the hydrogen bonding from water as well as Gdm(+).	Water	182-187	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	54-58
22994915-11	2012	Two STEC O124:H19 strains isolated from rectal swabs and water with a 5-month interval harbored the stx1/stx2/saa/ehxA genotype, and showed an indistinguishable PFGE profile.	Water	57-62	serum amyloid A protein	Bos taurus	110-113
22467332-12	2012	With chronic UVB irradiation, Pparg-/-(epi) mice exhibited a sustained increase in erythema and transepidermal water loss relative to wildtype littermates.	Water	111-116	exocrine pancreatic insufficiency	Mus musculus	30-43
22983115-7	2012	Modelling predicts that the positive and negative perturbations of PIP2;1 expression alter water flow into LRP, thereby slowing lateral root emergence (LRE).	Water	91-96	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	67-73
22772988-3	2012	Our results show that a variant of the Water Mediated and Substrate Assisted (WMSA) mechanism that we previously deduced for Dpo4 and T7 DNA polymerases is preferred for Pol kappa as well, suggesting its broad applicability.	Water	39-44	DNA polymerase lambda	Homo sapiens	170-179
22718347-1	2012	Aquaporin-4 (AQP4) is a water channel expressed in astrocytes, skeletal muscle and epithelial cells that forms supramolecular aggregates in plasma membranes called orthogonal arrays of particles (OAPs).	Water	24-29	aquaporin 4	Homo sapiens	0-11
22718347-1	2012	Aquaporin-4 (AQP4) is a water channel expressed in astrocytes, skeletal muscle and epithelial cells that forms supramolecular aggregates in plasma membranes called orthogonal arrays of particles (OAPs).	Water	24-29	aquaporin 4	Homo sapiens	13-17
22691952-4	2012	microinjection of neuropeptide RFRP-1 significantly reduced food and water intake in chicks.	Water	69-74	neuropeptide VF precursor	Rattus norvegicus	31-35
22609600-1	2012	We prepared scatteredly cyclic RGDfK-conjugated water-dispersible superparamagnetic iron oxide nanoparticles (cRGDfK-WSPIONs) and investigated their cellular uptake to MS-1 cells (mouse endothelial cell lines, express integrin alpha(v)beta(3)) and MCF-7 cells (human breast cancer cells, express low level of integrin alpha(v)beta(3)) using in vitro MRI.	Water	48-53	integrin subunit alpha V	Homo sapiens	218-241
22609600-1	2012	We prepared scatteredly cyclic RGDfK-conjugated water-dispersible superparamagnetic iron oxide nanoparticles (cRGDfK-WSPIONs) and investigated their cellular uptake to MS-1 cells (mouse endothelial cell lines, express integrin alpha(v)beta(3)) and MCF-7 cells (human breast cancer cells, express low level of integrin alpha(v)beta(3)) using in vitro MRI.	Water	48-53	integrin subunit alpha V	Homo sapiens	218-242
22674380-3	2012	We obtained that the different biological processes of ABCB1 inhibited transport and signal network repressed carbon dioxide transport, ER to Golgi vesicle-mediated transport, folic acid transport, mitochondrion transport along microtubule, water transport, BMP signaling pathway, Ras protein signal transduction, transforming growth factor beta receptor signaling pathway in chimpanzee compared with the inhibited network of the human left cerebrum, as a result of inducing inhibition of mitochondrion transport along microtubule and BMP signal-induced cell shape in chimpanzee left cerebrum.	Water	241-246	ATP binding cassette subfamily B member 1	Pan troglodytes	55-60
22843170-13	2012	Balneotherapy and within this the sulphurous spa water alone may be effective for the attenuation of pain in patients with hand osteoarthrosis.	Water	49-54	surfactant protein A2	Homo sapiens	45-48
22940201-2	2012	The insensitivity of water permeability in frog hair cells to extracellular mercury suggests that an amphibian homologue of the water channel aquaporin-4 (AQP4) may mediate water transport in these cells.	Water	128-133	aquaporin 4	Canis lupus familiaris	155-159
22940201-2	2012	The insensitivity of water permeability in frog hair cells to extracellular mercury suggests that an amphibian homologue of the water channel aquaporin-4 (AQP4) may mediate water transport in these cells.	Water	128-133	aquaporin 4	Canis lupus familiaris	155-159
22198003-6	2012	32% washed their hands before attending each client, 59% cleaned instruments with disinfectant between clients, 96.1% washed razors with tap water before use on a new client, 92.6% also washed their razors with an antiseptic solution after every use, 87% used a new blade on new clients and 55% used disinfectants for skin cuts.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	137-140
22387049-5	2012	The most important water channel in the CNS is the astroglial water channel protein aquaporin-4 (AQP4) which is arranged in a morphologically spectacular way, the so-called orthogonal arrays of particles (OAPs) to be observed in freeze-fracture replicas.	Water	19-24	aquaporin 4	Homo sapiens	84-95
22387049-5	2012	The most important water channel in the CNS is the astroglial water channel protein aquaporin-4 (AQP4) which is arranged in a morphologically spectacular way, the so-called orthogonal arrays of particles (OAPs) to be observed in freeze-fracture replicas.	Water	19-24	aquaporin 4	Homo sapiens	97-101
22387049-9	2012	As a consequence, agrin loss may lead to a redistribution of AQP4 and a compromised directionality of water transport out of the cell, finally to cytotoxic edema.	Water	102-107	agrin	Homo sapiens	18-23
22903161-1	2012	In order to assess the contribution of the water channel aquaporin-5 (AQP5) to water transport by salivary gland acinar cells, we measured the cell volume and activation energy (E (a)) of diffusive water permeability in isolated parotid acinar cells obtained from AQP5-G103D mutant and their wild-type rats.	Water	79-84	aquaporin 5	Rattus norvegicus	70-74
22903161-1	2012	In order to assess the contribution of the water channel aquaporin-5 (AQP5) to water transport by salivary gland acinar cells, we measured the cell volume and activation energy (E (a)) of diffusive water permeability in isolated parotid acinar cells obtained from AQP5-G103D mutant and their wild-type rats.	Water	79-84	aquaporin 5	Rattus norvegicus	70-74
22903161-7	2012	These results suggested that AQP5 was the main pathway for water transport in the acinar cells and that it was responsible for the rapid agonist-induced acinar cell shrinkage and also necessary to keep the acinar cell volume reduced during the steady secretion in the wild-type rat.	Water	59-64	aquaporin 5	Rattus norvegicus	29-33
2532476-1	1989	Atrial natriuretic factor (ANF) is a peptide hormone that increases renal NaCl and water excretion.	Water	83-88	natriuretic peptide A	Rattus norvegicus	0-25
22668974-11	2012	These results showed that berberine was able to increase the expression of NHE3 and AQP4, suggesting that berberine might exhibit its anti-diarrhoeal effect partially by enhancing the absorption of Na(+) and water.	Water	208-213	aquaporin 4	Mus musculus	84-88
22038315-4	2012	Leptin levels significantly increased immediately after WWB with tap water and ISCO(2) (both P &lt; 0.05), and remained significantly higher than those at baseline even 30 minutes after WWB with tap water (P &lt; 0.05).	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
2532476-1	1989	Atrial natriuretic factor (ANF) is a peptide hormone that increases renal NaCl and water excretion.	Water	83-88	natriuretic peptide A	Rattus norvegicus	27-30
22038315-4	2012	Leptin levels significantly increased immediately after WWB with tap water and ISCO(2) (both P &lt; 0.05), and remained significantly higher than those at baseline even 30 minutes after WWB with tap water (P &lt; 0.05).	Water	199-204	nuclear RNA export factor 1	Homo sapiens	195-198
22038315-7	2012	The sublingual temperature rose significantly after 10 minutes of WWB with tap water (0.96 +- 0.16 C relative to baseline, P &lt; 0.01) and after the same duration of WWB with ISCO(2) (1.24 +- 0.34 C relative to baseline, P &lt; 0.01).	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
2532476-7	1989	Simulated 2.5-5% increases in glomerular filtration rate also increased simulated NaCl and water excretion rates to experimentally observed levels in response to ANF.	Water	91-96	natriuretic peptide A	Rattus norvegicus	162-165
2606851-5	1989	An intravenous injection of IL-2 caused an increased lung water (P less than 0.01), an increased 125I-albumin lung-to-plasma ratio (P less than 0.05), and a significant increase in the absolute number of neutrophils, lymphocytes, and macrophages in BAL fluid compared with the saline control.	Water	58-63	interleukin-2	Cavia porcellus	28-32
22713791-3	2012	Most patients with NMO are seropositive for immunoglobulin autoantibodies (AQP4-IgG) against AQP4, the principal water channel of astrocytes.	Water	113-118	aquaporin 4	Homo sapiens	75-79
22713791-3	2012	Most patients with NMO are seropositive for immunoglobulin autoantibodies (AQP4-IgG) against AQP4, the principal water channel of astrocytes.	Water	113-118	aquaporin 4	Homo sapiens	93-97
22713791-5	2012	Here, we review the evidence for this and alternative proposed NMO pathogenesis mechanisms, such as AQP4-IgG-induced internalization of AQP4 and glutamate transporters, complement-independent cell-mediated cytotoxicity, and AQP4-IgG inhibition of AQP4 water transport function.	Water	252-257	aquaporin 4	Homo sapiens	100-104
2533676-3	1989	Especially if the manufacturers" guidelines are not followed strictly and the device is operated with tap water, indoor particle concentrations may reach up to 50 times US outdoor standards for toxic particle concentration.	Water	106-111	nuclear RNA export factor 1	Homo sapiens	102-105
2533680-1	1989	Infusion of ANP has been shown to increase the urinary excretion of sodium and water.	Water	79-84	natriuretic peptide A	Rattus norvegicus	12-15
22735908-0	2012	Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development             and healing of water immersion and restraint stress-induced gastric ulcers in             rats.	Water	98-103	phosphatase and tensin homolog	Rattus norvegicus	20-24
2690408-1	1989	Human exposure to volatile organic compounds (VOCs) in tap water is often assumed to be dominated by ingestion of drinking water.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
22119284-3	2012	We collected daily samples of air, fallout deposition, and tap water starting directly after the incident and measured their radioactivity.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
22119284-8	2012	Radioactivity in tap water caused by the accident was detected several days after detection of radioactivity in fallout in the area.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
2690408-3	1989	A three-compartment model is used to simulate the 24-h concentration history of VOCs in the shower, bathroom, and remaining household volumes as a result of tap water use.	Water	161-166	nuclear RNA export factor 1	Homo sapiens	157-160
2531013-2	1989	Previous reports suggested an inhibitory effect of ANF on some of the central actions of ANG II, such as water intake and vasopressin release.	Water	105-110	natriuretic peptide A	Rattus norvegicus	51-54
22776833-3	2012	AIM OF STUDY: In this study, we examined the effects of a water-soluble beta-d-fructan (MDG-1) from O. japonicus on type 2 diabetes through the PI3K/Akt pathway in a diabetic KKAy mouse model.	Water	58-63	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	88-93
2556583-1	1989	During an electron microscopical study of the localization of the nucleoside diphosphatase IDPase in Reissner"s membrane of the inner ear, it was discovered that the distilled water in the knife trough produced an annoying artefact.	Water	176-181	nudix hydrolase 16	Homo sapiens	91-97
22658830-4	2012	With 0.98 mM H(2)O(2) and 0.4 g L(-1) Fe(3)O(4)@ALG/Fe, 100% of NOF and 90% of TOC is removed within 60 min, and the fluorine element in NOF molecule changes into F(-) ions within 1 min, indicating that NOF degradation in this Fenton-like reaction is performed through direct defluorination pathway.	Water	13-18	mitochondrial ribosomal protein L49	Homo sapiens	64-67
2804695-5	1989	These inhibitory findings implicate an anion antiporter for mediating Cl flux (and thus water) between blood and CSF.	Water	88-93	colony stimulating factor 2	Rattus norvegicus	113-116
22896675-5	2012	Animals lacking the water channel aquaporin-4 (AQP4) in astrocytes exhibit slowed CSF influx through this system and a ~70% reduction in interstitial solute clearance, suggesting that the bulk fluid flow between these anatomical influx and efflux routes is supported by astrocytic water transport.	Water	20-25	aquaporin 4	Homo sapiens	47-51
22896675-5	2012	Animals lacking the water channel aquaporin-4 (AQP4) in astrocytes exhibit slowed CSF influx through this system and a ~70% reduction in interstitial solute clearance, suggesting that the bulk fluid flow between these anatomical influx and efflux routes is supported by astrocytic water transport.	Water	281-286	aquaporin 4	Homo sapiens	47-51
2477068-1	1989	To understand the mechanism by which colipase acts as a protein cofactor for anchoring pancreatic lipase at triacylglycerol/water interface, we have used an immunochemical approach.	Water	124-129	pancreatic lipase	Homo sapiens	87-104
22696438-5	2012	The light-induced equilibrium shifts were repeated four times without major signs of degradation; the Ru-S coordination bond in [2](2+) can be described as a robust, light-sensitive, supramolecular bond in water.	Water	206-211	RUS family member 1	Homo sapiens	102-106
22696438-8	2012	Upon exposure of the Ru-decorated vesicles to visible light, the Ru-S bond is selectively broken, thus releasing [1](2+) that stays at the water-bilayer interface.	Water	139-144	RUS family member 1	Homo sapiens	65-69
22879717-8	2012	In addition, spa spring water attenuated the differentiation process of subsets of CD4(+) T cells, i.e., Th1, Th2 and Th17 cells.	Water	24-29	negative elongation factor complex member C/D	Homo sapiens	105-108
2532951-4	1989	At higher doses, where renal responses to rANP(99-126) were less (downside of a biphasic response), both iso-rANP(1-45) and (17-45) had greater effects on water and electrolyte excretion than rANP(99-126).	Water	155-160	natriuretic peptide A	Rattus norvegicus	109-113
22879717-10	2012	CONCLUSION: Spa spring water treatment suppressed the inflammatory cytokines production and also modulated the differentiation of CD4(+) T cells into Th1, Th2, and Th17 cells, but not the T(regs) cells.	Water	23-28	negative elongation factor complex member C/D	Homo sapiens	150-153
22098336-9	2012	CaSR knockdown or Calhex231, however, prevented the reversible effect of H(2)O(2).	Water	73-78	calcium-sensing receptor	Rattus norvegicus	0-4
2532951-4	1989	At higher doses, where renal responses to rANP(99-126) were less (downside of a biphasic response), both iso-rANP(1-45) and (17-45) had greater effects on water and electrolyte excretion than rANP(99-126).	Water	155-160	natriuretic peptide A	Rattus norvegicus	109-113
2583429-15	1989	The main UVDR max ascended from 28.2 to 38.2 cm H2O.	Water	48-51	ERCC excision repair 5, endonuclease	Homo sapiens	9-13
22401992-4	2012	MyD88(-/-) mice displayed impaired spatial and working memory as detected by the Barnes maze, the water T-maze and the passive avoidance tests.	Water	98-103	myeloid differentiation primary response gene 88	Mus musculus	0-5
23077787-4	2012	Superoxide dismutase (SOD) activity was very low in roots and shoots and showed non-significant increase under water-stress in tolerant genotypes.	Water	111-116	SOD	Triticum aestivum	0-20
23077787-4	2012	Superoxide dismutase (SOD) activity was very low in roots and shoots and showed non-significant increase under water-stress in tolerant genotypes.	Water	111-116	SOD	Triticum aestivum	22-25
26523086-4	2012	For Cryptosporidum, oocyst recovery in tap water was significantly higher for ultrafiltration (68%) versus the capsule filter (37%); ultrafiltration recovered 65% of oocysts in surface water versus 61% for the capsule filter.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
22805117-5	2012	Mozart for H(2)O(2) and its scavenging enzymes catalase (CAT) and ascorbate peroxidase (APX) during leaf and plant development.	Water	11-16	catalase-3-like	Brassica napus	47-55
22805117-5	2012	Mozart for H(2)O(2) and its scavenging enzymes catalase (CAT) and ascorbate peroxidase (APX) during leaf and plant development.	Water	11-16	catalase-3-like	Brassica napus	57-60
22805117-7	2012	With increasing H(2)O(2) levels, CAT and APX activities declined, so it is likely that similar mechanisms are used in oilseed rape and Arabidopsis to control H(2)O(2) levels.	Water	16-21	catalase-3-like	Brassica napus	33-36
21649853-7	2012	The results of this review indicate that patients who underwent irrigation with tap water immediately following alkali burns at the scene of injury had significantly better clinical and ocular outcomes.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
21649853-12	2012	IMPLICATIONS AND CONCLUSIONS: As prompt eye irrigation with tap water immediately after alkali burns had better outcomes, it would be important to commence eye irrigation immediately after burns are sustained.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
22732064-1	2012	Deprotonation of zinc-bound water in carbonic anhydrase II is the rate-limiting step in the catalysis of carbon dioxide between gas- and water-soluble forms.	Water	28-33	carbonic anhydrase 2	Homo sapiens	37-58
22732064-1	2012	Deprotonation of zinc-bound water in carbonic anhydrase II is the rate-limiting step in the catalysis of carbon dioxide between gas- and water-soluble forms.	Water	137-142	carbonic anhydrase 2	Homo sapiens	37-58
22441306-6	2012	The expression of MreB-RFP in single emulsion droplets leads to the formation of micrometer-scale protein patches distributed at the water/oil interface.	Water	133-138	tripartite motif containing 27	Homo sapiens	23-26
22424887-3	2012	Aquaporin 5 (AQP5) is a membrane protein that forms water channels, and plays an important role in water transport.	Water	52-57	aquaporin 5	Rattus norvegicus	0-11
22424887-3	2012	Aquaporin 5 (AQP5) is a membrane protein that forms water channels, and plays an important role in water transport.	Water	52-57	aquaporin 5	Rattus norvegicus	13-17
22424887-3	2012	Aquaporin 5 (AQP5) is a membrane protein that forms water channels, and plays an important role in water transport.	Water	99-104	aquaporin 5	Rattus norvegicus	0-11
22087760-0	2012	Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactants: a delivery system for poorly water-soluble drug.	Water	122-127	methylmalonyl-CoA mutase	Homo sapiens	59-62
22622010-3	2012	Therefore, the binding dynamics and involved molecular interactions between VWF A1 domain and GPIbalpha in both water and physiological saline are investigated using molecular dynamics simulations and all-atom models.	Water	112-117	glycoprotein Ib platelet subunit alpha	Homo sapiens	94-103
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Water	39-44	heme oxygenase 1	Rattus norvegicus	141-153
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Water	39-44	nitric oxide synthase 1	Rattus norvegicus	195-199
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Water	39-44	heme oxygenase 1	Rattus norvegicus	141-145
22350767-0	2012	Water-soluble chlorophyll protein (WSCP) of Arabidopsis is expressed in the gynoecium and developing silique.	Water	0-5	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	35-39
22350767-1	2012	Water-soluble chlorophyll protein (WSCP) has been found in many Brassicaceae, most often in leaves.	Water	0-5	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	35-39
22714714-1	2012	Aquaporin-4 (AQP-4), the most important water channel in the brain, is expressed by astrocyte end feet abutting microvessels.	Water	40-45	aquaporin 4	Homo sapiens	0-11
23016165-0	2004	(68)Ga-1,4,7-Triazacyclononane,1-glutaric acid-4,7-acetic acid-1,2-diaminoethane-gamma-5,8-dideazfolic acid (P3238) Folic acid (folate) is a water-soluble B vitamin (1) that is essential for methylation and DNA synthesis.	Water	141-146	mediator complex subunit 25	Homo sapiens	58-64
23079979-1	2012	The insulin growth factor 1/phosphatase and tensin homologue deleted on chromosome 10/Akt/forkhead box (IGF-1/PTEN/Akt/FoxO) signaling pathway reportedly exhibits gastroprotective effects by reducing water immersion and restraint stress (WRS)-induced gastric mucosal cell apoptosis.	Water	200-205	phosphatase and tensin homolog	Rattus norvegicus	110-114
22824864-4	2012	PQQ inhibited protein tyrosine phosphatase 1B (PTP1B), which negatively regulates the EGFR signaling by tyrosine dephosphorylation, to oxidatively modify the catalytic cysteine through its redox cycling activity to generate H(2)O(2).	Water	224-229	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	47-52
22967539-0	2012	Portable mercury sensor for tap water using surface plasmon resonance of immobilized gold nanorods.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
22967539-1	2012	The surface plasmon resonance of surface immobilized gold nanorods (Au NRs) was used to quantify mercury in tap water.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
22967539-5	2012	The possibility to using glass substrates with immobilized Au NRs is a significant step towards the analysis of mercury in tap water flows at this low concentration level.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
22865659-6	2012	All IFPs showed high thermal stability (345-400  C); IFP-1 and IFP-4 were stable in boiling water for 7 d. A detailed porosity analysis was performed on the basis of adsorption measurements by using various gases.	Water	92-97	tripartite motif containing 34	Homo sapiens	53-58
22865659-9	2012	In situ IR spectroscopy showed that CO(2) is physisorbed on IFP-1-4 under dry conditions and that both CO(2) and H(2)O are physisorbed on IFP-1 under moist conditions.	Water	113-118	tripartite motif containing 34	Homo sapiens	138-143
22714024-2	2012	The polyoxometalate, Cs(3)[alpha-PW(11)O(39){cis-Pt(NH(3))(2)}(2)] 8H(2)O (Cs-1), afforded by a stoichiometric reaction of mono-lacunary Keggin polyoxotungstate with cis-diamminedichloroplatinum(ii) in water, followed by crystallization from water, was obtained as analytically pure, homogeneous, yellow crystals.	Water	202-207	chorionic somatomammotropin hormone 1	Homo sapiens	75-79
22714024-2	2012	The polyoxometalate, Cs(3)[alpha-PW(11)O(39){cis-Pt(NH(3))(2)}(2)] 8H(2)O (Cs-1), afforded by a stoichiometric reaction of mono-lacunary Keggin polyoxotungstate with cis-diamminedichloroplatinum(ii) in water, followed by crystallization from water, was obtained as analytically pure, homogeneous, yellow crystals.	Water	242-247	chorionic somatomammotropin hormone 1	Homo sapiens	75-79
22898169-0	2012	Getting back on tap: the policy context and cost of ensuring access to low-cost drinking water in Massachusetts schools.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	16-19
22898169-10	2012	Water-provision strategies relying on tap water are more economical than bottled water in the long term.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	38-41
22898169-10	2012	Water-provision strategies relying on tap water are more economical than bottled water in the long term.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
22683474-7	2012	Under the formation of the enzyme-metal-substrate complex, Glu451 of Cu(II)-rat DPP III is sufficiently able to approach the water molecule via a very different orientation from that of the resting state; however, Glu451 of Cu(II)-rat del-DPP III is not able to access the water molecule.	Water	125-130	dipeptidylpeptidase 3	Rattus norvegicus	80-87
22683474-7	2012	Under the formation of the enzyme-metal-substrate complex, Glu451 of Cu(II)-rat DPP III is sufficiently able to approach the water molecule via a very different orientation from that of the resting state; however, Glu451 of Cu(II)-rat del-DPP III is not able to access the water molecule.	Water	273-278	dipeptidylpeptidase 3	Rattus norvegicus	80-87
23487846-0	2012	Unknown quantity: regulating radionuclides in tap water.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
22859021-1	2012	The reaction of water with octahedral bis-, tris- and tetrakis-(phosphine)tungsten, (phosphine)molybdenum and (phosphine)chromium complexes has been studied using B3LYP/def2-TZVPP level of DFT to elucidate dissociative, associative and hydride migratory insertion mechanisms for hydrogen elimination.	Water	16-21	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	165-168
22683865-4	2012	Our data demonstrated that TSG significantly (P&lt; 0.05) increased cell survival, alkaline phosphatase (ALP) activity, calcium deposition, and the mRNA expression of ALP, collagen I (COL-I) and osteocalcin (OCN) in the presence of H(2)O(2).	Water	232-237	twisted gastrulation BMP signaling modulator 1	Mus musculus	27-30
22683865-5	2012	In addition, TSG decreased the production of receptor activator of nuclear factor-kappaB ligand (RANKL), interleukin-6 (IL-6), intracellular reactive oxygen species and malondialdehyde (MDA) of osteoblastic MC3T3-E1 cells induced by H(2)O(2).	Water	233-238	twisted gastrulation BMP signaling modulator 1	Mus musculus	13-16
22772314-2	2012	The purpose of this investigation was to examine the relationship between beta(2)AR density on lymphocytes and indices of lung water in healthy humans exposed to   17 h of hypoxia (FIO2 = 12.5% in a hypoxia tent).	Water	127-132	adrenoceptor beta 2	Homo sapiens	74-83
22772314-11	2012	The post-hypoxia increase in beta(2)AR density was significantly related to the reduction in lung water (r=-0.64, p&lt;0.05), with the subjects with the greatest increase in density demonstrating the largest decline in lung water.	Water	98-103	adrenoceptor beta 2	Homo sapiens	29-38
22772314-11	2012	The post-hypoxia increase in beta(2)AR density was significantly related to the reduction in lung water (r=-0.64, p&lt;0.05), with the subjects with the greatest increase in density demonstrating the largest decline in lung water.	Water	224-229	adrenoceptor beta 2	Homo sapiens	29-38
22752009-0	2012	Morphology and crystallization kinetics of compact (HGW) and porous (ASW) amorphous water ice.	Water	84-89	chromosome 2 open reading frame 49	Homo sapiens	69-72
22794353-6	2012	The crystal structure of apigenin and luteolin in complex with the catalytic subunit of Zea mays CK2 has been solved, revealing their ability to interact with both the hinge region (Val116) and the positive area near Lys68 and the conserved water W1, the two main polar ligand anchoring points in the CK2 active site.	Water	241-246	Calcium-dependent protein kinase 6	Zea mays	97-100
22706888-0	2012	Determination of fluoride in tap water in Morocco using a direct electrochemical method.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
22706888-1	2012	This study aimed to analyze the fluoride concentration in tap drinking water in different cities of Morocco using an electrochemical ion-selective method.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	58-61
22883355-11	2012	Tap water was the main source of water consumed at home by the majority of children (77.8%).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
22883355-11	2012	Tap water was the main source of water consumed at home by the majority of children (77.8%).	Water	33-38	nuclear RNA export factor 1	Homo sapiens	0-3
2696060-1	1989	nov. isolated from French spa water.	Water	30-35	surfactant protein A2	Homo sapiens	26-29
22658390-3	2012	DESIGN: Prospective feasibility study of immediate colonoscopy after tap-water enema without oral bowel preparation, aided by water-jet pumps and mechanical suction devices in patients admitted to the intensive care unit with a primary diagnosis of severe lower GI bleeding.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
2818843-10	1989	Doses of CCK and naloxone, an opioid receptor blocker, combined to inhibit ethanol intake in an infra-dose-additive manner in water-deprived rats.	Water	126-131	cholecystokinin	Rattus norvegicus	9-12
2611291-1	1989	Study of temperature dependence of heat capacity in denatured biopolymers (collagen, elastin, lysozyme, DNA) with 10-15% of bound water revealed a characteristic jump at some critical temperature Tc.	Water	130-135	elastin	Homo sapiens	85-92
2586050-3	1989	Oral and external use of mineral water and mud applications proved most beneficial spa treatment modalities.	Water	33-38	surfactant protein A2	Homo sapiens	83-86
22544572-1	2012	A well-recognized enzyme consuming ascorbate is ascorbate peroxidase (APX), which catalyses the reduction of hydrogen peroxide to water with the simultaneous oxidation of ascorbate with a high specificity.	Water	130-135	L-ascorbate peroxidase 1, cytosolic	Brassica rapa	48-68
22544572-1	2012	A well-recognized enzyme consuming ascorbate is ascorbate peroxidase (APX), which catalyses the reduction of hydrogen peroxide to water with the simultaneous oxidation of ascorbate with a high specificity.	Water	130-135	L-ascorbate peroxidase 1, cytosolic	Brassica rapa	70-73
2601607-3	1989	Delineate the effect of tap water pressure and temperature on the quality of contamination wash-out from medical appliances as well as tap water consumption required for different designs of the nozzles at varying water pressures and temperatures.	Water	139-144	nuclear RNA export factor 1	Homo sapiens	135-138
22547269-12	2012	In case of glutathione peroxidase-1, Lp9, Lp91 and Lp55 showed significant (P &lt; 0.001) up-regulation in the gene expression to the level of 5.451, 8.706 and 10.083 folds, respectively when HT-29 was challenged with 0.1 mM H(2)O(2).	Water	225-230	glutathione peroxidase 1	Homo sapiens	11-35
2760472-4	1989	C3(H2O) eluted as a homogeneous peak well resolved from native C3, C3b, high molecular weight aggregates and small degradation fragments.	Water	3-6	complement C3	Homo sapiens	67-70
23189733-6	2012	CONCLUSION: Water extracts from bran-processed A. lancea can obviously increase small intestinal peristalsis and GAS level, indicating that A. lancea has the effect for strengthening spleen and stomach after stir-baking with bran.	Water	12-17	gastrin	Rattus norvegicus	113-116
22632070-1	2012	Deep eutectic solvents promoted the stabilization of the collapsed state of elastin-like recombinamers  - and the subsequent formation of aggregates  - upon the loss of the structural water molecules involved in hydrophobic hydration.	Water	184-189	elastin	Homo sapiens	76-83
2511902-0	1989	The binding of G-protein to rod outer segment phospholipids at the nitrogen-water interface.	Water	76-81	kinetochore associated 1	Homo sapiens	28-31
22540516-14	2012	Chronic tempol treatment (1 mmol/L in tap water for 1 month) prevented the reduced hyperpolarization to ACh.	Water	42-47	SEC14-like lipid binding 2	Rattus norvegicus	38-41
2758720-3	1989	The lead source was ultimately traced to the daily administration of powdered formula which was prepared with home tap water having a first-draw lead content of 130 parts per billion.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
23723021-14	2012	The important functions of CLC Cl(-) channels were also revealed by human diseases and mouse models, with phenotypes including myotonia, renal loss of salt and water, deafness, blindness, leukodystrophy, and male infertility.	Water	160-165	Charcot-Leyden crystal galectin	Homo sapiens	27-30
2758720-4	1989	This case suggests that whenever infants are fed powdered formula, consideration should be given to analysis of the home tap water for lead content.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
22411733-0	2012	Tap water or "sterile" water for sinus irrigations: what are our patients using?	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
2768486-1	1989	The efficacy of a strategy to prevent tap water scalds was evaluated in a population at risk.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
22411733-2	2012	Due to potential concerns regarding infection, patients are commonly recommended to use distilled, bottled, or boiled tap water when mixing these solutions.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
22411733-3	2012	Anecdotally, patients frequently inform otolaryngologists that they use tap water for irrigation preparation.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
22411733-9	2012	However, tap water was used by 48% and the most common reason cited for using tap water was convenience.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
2790002-0	1989	Interface-mediated inactivation of pancreatic lipase by a water-reactive compound: 2-sulfobenzoic cyclic anhydride.	Water	58-63	pancreatic lipase	Homo sapiens	35-52
22542745-6	2012	RESULTS: When stored in water, P90 showed an increase, whereas Z350 decreased in translucency.	Water	24-29	cellular inhibitor of PP2A	Homo sapiens	31-34
22542745-13	2012	CONCLUSIONS: P90 was more stable in red wine than the other materials and became more translucent in water whether metacrilate-based materials became more opaque.	Water	101-106	cellular inhibitor of PP2A	Homo sapiens	13-16
2787112-1	1989	A previous study of pregnant women whose water supply was potentially contaminated revealed a significant increase in spontaneous abortions among those drinking tap as opposed to bottled water, regardless of exposure to the contamination.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	161-164
2817338-0	1989	Isolation of cathepsin D using three-phase partitioning in t-butanol/water/ammonium sulfate.	Water	69-74	cathepsin D	Bos taurus	13-24
22473056-2	2012	Aquaporin-4 (AQP4) is the major water channel in adult brain and is primarily expressed in astrocytes.	Water	32-37	aquaporin 4	Mus musculus	0-11
22473056-2	2012	Aquaporin-4 (AQP4) is the major water channel in adult brain and is primarily expressed in astrocytes.	Water	32-37	aquaporin 4	Mus musculus	13-17
22339887-5	2012	RESULTS: The estimate for the percentage of individuals who reported total drinking water in 2005-2006 was significantly (P &lt; 0 0000) smaller (76 9 %) than that for 2003-2004 (87 1 %), attributable to a lower percentage reporting tap water (54 1 % in 2005-2006 v. 67 0 % in 2003-2004; P = 0 0001).	Water	84-89	nuclear RNA export factor 1	Homo sapiens	233-236
2738794-12	1989	Aerosol equipment cleansed with tap water and the showers were implicated as means of exposure by patients to contaminated potable water.	Water	131-136	nuclear RNA export factor 1	Homo sapiens	32-35
22652439-1	2012	Magnetic nanoparticles (NP) were developed for the active brain targeting of water-soluble P-glycoprotein (P-gp) substrate rhodamine 123 (Rh123).	Water	77-82	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	91-105
22652439-1	2012	Magnetic nanoparticles (NP) were developed for the active brain targeting of water-soluble P-glycoprotein (P-gp) substrate rhodamine 123 (Rh123).	Water	77-82	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	107-111
22552367-0	2012	Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/beta-catenin signaling pathway.	Water	33-38	catenin (cadherin associated protein), beta 1	Mus musculus	163-175
22537920-2	2012	The photocatalytic activity and the dissolution of Ag(+) from different catalysts were investigated during the photodegradation of 2-chlorophenol (2-CP) and phenol in ultrapure water and tap water with visible-light irradiation.	Water	191-196	nuclear RNA export factor 1	Homo sapiens	187-190
22537920-4	2012	Ag-AgBr/MA-Ti1 was considered the better catalyst for practical applications because its Ag(+) dissolution was minimal (0.4 mg L(-1) in ultrapure water and 5 mug L(-1) in tap water), although its photoactivity was slightly less than that of Ag-AgBr/MA.	Water	175-180	nuclear RNA export factor 1	Homo sapiens	171-174
2525840-3	1989	Newly synthesized monomeric NS1 is a hydrophilic and water-soluble protein which cannot be pelleted at 75,000 g. After dimerization, however, NS1 showed increased hydrophobicity in a Triton X-114 phase partitioning system and was completely pelletable at 75,000 g; these findings are consistent with NS1 becoming membrane-associated.	Water	53-58	influenza virus NS1A binding protein	Homo sapiens	28-31
22612064-5	2012	However, at greater electron energies, we are able to locally manipulate the water using the STM tip.	Water	77-82	sulfotransferase family 1A member 3	Homo sapiens	93-96
22708830-9	2012	RESULTS: The percentage of tap water consumption remained relatively stable and a preferred choice, with 58.99% in 2001 and 58.25% in 2011.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
22708830-15	2012	CONCLUSIONS: Personal health belief, housing condition, age, personal income, education, taste and if worm ever founded in tap water affected domestic drinking water choices in Shanghai.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
2758320-4	1989	The fact that H-7 treatment prevented the accumulation of water and certain electrolytes in the brain indicates that the protein kinase C may be activated not only in the neuronal structures but also in the microvessels during ischemia, which can lead directly or via certain calcium-mediated mechanisms to the opening of tight junctions resulting in the development of brain edema.	Water	58-63	solute carrier family 9 member A2	Rattus norvegicus	14-17
22540891-0	2012	Pb particles from tap water: bioaccessibility and contribution to child exposure.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
22884076-1	2012	BACKGROUND: More and more Chinese drink hot water from water dispensers while many children were scalded due to this change.	Water	44-49	alcohol dehydrogenase iron containing 1	Homo sapiens	40-43
22884076-1	2012	BACKGROUND: More and more Chinese drink hot water from water dispensers while many children were scalded due to this change.	Water	55-60	alcohol dehydrogenase iron containing 1	Homo sapiens	40-43
2475172-3	1989	The O2" hydroxyl groups of both rC and araC residues form intramolecular hydrogen bonds with N2 of the 5" guanine residue and replace the bridging water molecules in the deep groove of Z-DNA, which stabilize the guanine in the syn conformation.	Water	147-152	synemin	Homo sapiens	227-230
22354518-1	2012	NMO-IgG autoantibody selectively binds to aquaporin-4 (AQP4), the most abundant water channel in the central nervous system and is now considered a useful serum biomarker of neuromyelitis optica (NMO).	Water	80-85	aquaporin 4	Homo sapiens	42-53
22354518-1	2012	NMO-IgG autoantibody selectively binds to aquaporin-4 (AQP4), the most abundant water channel in the central nervous system and is now considered a useful serum biomarker of neuromyelitis optica (NMO).	Water	80-85	aquaporin 4	Homo sapiens	55-59
22497348-7	2012	The addition of salt into the C(16)TAB/AS/H(2)O mixed system, leads to a certain degree of decrease in CMC(2).	Water	42-47	C-X9-C motif containing 2	Homo sapiens	103-109
22293942-0	2012	Association of glutathione S-transferase Omega 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-beta), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water.	Water	277-282	glutathione S-transferase omega 1	Homo sapiens	15-50
22293942-5	2012	We evaluated the association of the presence of A140D and E208K polymorphisms of GSTO1-1 gene with the expression of genes codifying for proteins involved in the inflammatory and apoptotic response in a human population chronically exposed to iAs through drinking water.	Water	264-269	glutathione S-transferase omega 1	Homo sapiens	81-88
22497348-8	2012	In addition to counterion effect, the co-ion effect on CMC(2) of the mixed system was explained using Collins" concept of matching water affinities.	Water	131-136	C-X9-C motif containing 2	Homo sapiens	55-61
2548610-4	1989	When both IHP and BZF are added to the mixed-spin derivatives (H2O, SCN-, OCN-, and NO2-) of human methemoglobin, the spin equilibrium is shifted toward higher spin by about 700 cal/mol, similar to the spin change detected in derivatives of carp methemoglobin upon addition of IHP alone.	Water	63-66	spindlin 1	Homo sapiens	45-49
2548610-4	1989	When both IHP and BZF are added to the mixed-spin derivatives (H2O, SCN-, OCN-, and NO2-) of human methemoglobin, the spin equilibrium is shifted toward higher spin by about 700 cal/mol, similar to the spin change detected in derivatives of carp methemoglobin upon addition of IHP alone.	Water	63-66	hemoglobin subunit gamma 2	Homo sapiens	99-112
22813583-14	2012	Thus multiple AQP4 mRNAs may allow long-term regulation of the balance between M1 and M23 AQP4 isoforms in the cell and thus water permeability of the plasma membrane.	Water	125-130	aquaporin 4	Mus musculus	14-18
2548610-4	1989	When both IHP and BZF are added to the mixed-spin derivatives (H2O, SCN-, OCN-, and NO2-) of human methemoglobin, the spin equilibrium is shifted toward higher spin by about 700 cal/mol, similar to the spin change detected in derivatives of carp methemoglobin upon addition of IHP alone.	Water	63-66	spindlin 1	Homo sapiens	118-122
22813583-14	2012	Thus multiple AQP4 mRNAs may allow long-term regulation of the balance between M1 and M23 AQP4 isoforms in the cell and thus water permeability of the plasma membrane.	Water	125-130	aquaporin 4	Mus musculus	90-94
2729877-2	1989	Samples of tap water from Sudbury contained 109 +/- 46 micrograms Ni per L (P less than 0.01 vs 0.4 +/- 0.2 micrograms Ni per L in corresponding water samples from Hartford, Connecticut).	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
22873060-0	2012	[The internal cavities of pike alpha-parvalbumin probably contain water].	Water	66-71	parvalbumin	Homo sapiens	37-48
22873060-3	2012	Taking into account that the internal cavities in the parvalbumin are formed by hydrophobic amino acid residues, devoid of labile hydrogen atoms, it is possible to make the most appropriate assumption, namely, these cavities contain water molecules, hydrogen atoms of which are ultraslow exchangeable.	Water	233-238	parvalbumin	Homo sapiens	54-65
22660258-0	2012	[Tap water iontophoresis].	Water	5-10	nuclear RNA export factor 1	Homo sapiens	1-4
22660258-1	2012	Since 1968, tap water iontophoresis has been employed as the method of choice for treating palmoplantar hyperhidrosis.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
22660258-3	2012	Tap water iontophoresis also can extend symptom -free intervals in dyshidrotic palmar eczema.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
22528292-1	2012	Using the case of the catalytic domain of MMP-12 in complex with the known inhibitor CGS27023A, a recently assembled 3D (15)N-edited/(14)N,(12)C-filtered ROESY experiment is used to monitor and distinguish protein amide protons in fast exchange with bulk water from amide protons close to water molecules with longer residence times, the latter possibly reflecting water molecules of structural or functional importance.	Water	289-294	matrix metallopeptidase 12	Homo sapiens	42-48
2467743-5	1989	Unexpectedly, connexin43/water oocyte pairs developed high, asymmetrically voltage-dependent conductances, a property not displayed by the connexin32/water pairs.	Water	25-30	gap junction protein alpha 1 S homeolog	Xenopus laevis	14-24
22717747-0	2012	A time series study of drug sales and turbidity of tap water in Le Havre, France.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
22281753-7	2012	Noningestion water activities contributed more to the total exposure metric than did ingestion, but tap water THM concentrations were more predictive of blood THM levels than were metrics that incorporated water use.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
22281753-7	2012	Noningestion water activities contributed more to the total exposure metric than did ingestion, but tap water THM concentrations were more predictive of blood THM levels than were metrics that incorporated water use.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
22994033-4	2012	RESULTS: The bacterial count was statistically significantly about three times higher in the samples of the first burst tap water in comparison with the group of samples after letting the tap water run for two minutes 98.7, 78.5, 60.5-120.0 vs. 29.1, 25.8, 16.6-33.2 CFU/ml.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
2751382-4	1989	The scheme includes cleaving up of the water molecule at C11 and cleaving by the epoxide ring at the early stages and hydrolysis by the glycoside bonds at the later stages.	Water	39-44	RNA polymerase III subunit K	Homo sapiens	57-60
22994033-4	2012	RESULTS: The bacterial count was statistically significantly about three times higher in the samples of the first burst tap water in comparison with the group of samples after letting the tap water run for two minutes 98.7, 78.5, 60.5-120.0 vs. 29.1, 25.8, 16.6-33.2 CFU/ml.	Water	192-197	nuclear RNA export factor 1	Homo sapiens	188-191
22994033-5	2012	CONCLUSION: Two minutes running tap water contains about three times less bacterial count than first burst tap water	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
22994033-5	2012	CONCLUSION: Two minutes running tap water contains about three times less bacterial count than first burst tap water	Water	111-116	nuclear RNA export factor 1	Homo sapiens	32-35
22994033-5	2012	CONCLUSION: Two minutes running tap water contains about three times less bacterial count than first burst tap water	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
22357923-8	2012	Renal artery stenosis (7 days) or water restriction (48 h) suppressed Arap1 levels compared with controls (-64 and -62% in the clipped and contralateral kidney, respectively; and -50% after water restriction, P &lt; 0.01).	Water	34-39	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	Mus musculus	70-75
22483878-5	2012	The modified electrode was applied to detection hydroxylamine in the tap water, and the average recovery for the standards added was 96.0%.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
22583215-4	2012	Embedding-dependent RRD analyses are performed, up to high energies and rotational excitations, for the H(2) (16)O isotopologue of the water molecule.	Water	135-140	relaxin 2	Homo sapiens	104-108
22583215-6	2012	Rotational labeling of rovibrational states of H(2) (16)O proves to be increasingly difficult beyond about 10,000 cm(-1), close to the barrier to linearity of the water molecule.	Water	163-168	relaxin 2	Homo sapiens	47-51
22494481-4	2012	Compared with the tap water condition, tissue oxygenation index was 3.5% +- 1.3% higher in feet treated for 30 min with O(2)-infused water.	Water	133-138	nuclear RNA export factor 1	Homo sapiens	18-21
22494481-6	2012	When blood flow to the foot was occluded for 5 min, feet resting in O(2)-infused water maintained a 3-fold higher O(2) consumption rate than feet treated with tap water (9.1 +- 1.4 vs. 3.0 +- 1.0 microL 100 g(-1) min(-1)).	Water	163-168	nuclear RNA export factor 1	Homo sapiens	159-162
22349296-2	2012	We found hand washing with tap water after touching the flesh of fruit, rather than using alcohol swabs, to be very important for accurate SMBG.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
22416082-3	2012	Central h(Gly(2))GLP-2 administration significantly suppressed food and water intake with acute weight loss at 2 h. Further, central h(Gly(2))GLP-2 robustly induced c-Fos activation in the hypothalamic arcuate, dorsomedial, ventromedial, paraventricular, and the lateral hypothalamic nuclei.	Water	72-77	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-170
22310983-1	2012	Guanylin, a bioactive intestinal peptide, is involved in the cystic fibrosis transmembrane conductance (CFTR)-regulated electrolyte/water secretion in various epithelia.	Water	132-137	guanylate cyclase activator 2A	Rattus norvegicus	0-8
22487003-5	2012	RESULTS: An (131) I content of 210 Bq/kg in the tap water in Tokyo, which is located 230 km south of the FNP, on March 22 and of 3500 Bq/kg in spinach sampled in a city located 140 km southwest of the FNP on March 19 decreased over time to &lt;21 Bq/kg on March 27 and 12 Bq/kg on April 26, respectively.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
22465153-2	2012	Here, we review properties of these GPCR binding sites, using a unique combination of calculated physicochemical properties and water energetics (GRID, WaterMap and SZMAP) to provide a new perspective and rational assessment of druggability for each GPCR target binding site.	Water	128-133	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	36-40
22381982-11	2012	Moreover, experiments conducted with real water matrices, tap and surface water, showed that reaction, and formation of by-products, can take place both at the emission source point (household) and during drinking water production.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	58-61
22407327-4	2012	Incomplete iodide abstraction from [Ni(N(3)-CPQ)I(2)] with AgOTf leads to partial replacement of the iodide with hydroxide from adventitious water to give [Ni(N(3)-CPQ)I(1.6)(OH)(0.4)] (distorted TBP).	Water	141-146	TATA-box binding protein	Homo sapiens	196-199
22493272-4	2012	TRPM2 is activated by adenosine diphosphate ribose and hydrogen peroxide (H(2)O(2)), although the activation mechanism by H(2)O(2) is not well understood.	Water	74-79	transient receptor potential cation channel subfamily M member 2	Homo sapiens	0-5
22415374-7	2012	Furthermore, they show that "the proton" can be extracted by TBP (H(3)O(+)(TBP)(3)"complex") without its A(-) conjugated base, via a cation transfer mechanism (BMI(+) transfer to water).	Water	179-184	TATA-box binding protein	Homo sapiens	61-64
22415374-7	2012	Furthermore, they show that "the proton" can be extracted by TBP (H(3)O(+)(TBP)(3)"complex") without its A(-) conjugated base, via a cation transfer mechanism (BMI(+) transfer to water).	Water	179-184	TATA-box binding protein	Homo sapiens	66-91
22415374-8	2012	Experiments and simulations show that TBP plays an important role in the mutual solubility between water and ionic liquid, by different amounts, depending on the HA acid.	Water	99-104	TATA-box binding protein	Homo sapiens	38-41
22226778-0	2012	Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase.	Water	32-37	prostaglandin D2 synthase (brain)	Mus musculus	62-101
22226778-2	2012	Here we show the feasibility of a novel drug delivery system (DDS), utilizing L-PGDS, for poorly water-soluble compounds such as diazepam (DZP), a major benzodiazepine anxiolytic drug, and 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione (NBQX), an alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and anticonvulsant.	Water	97-102	prostaglandin D2 synthase (brain)	Mus musculus	78-84
22334710-6	2012	Because the AQP4 M1 isoform exhibits greater water permeability, in this study, we explored the possibility of microRNA-based transcriptional regulation of the AQP4 M1 promoter.	Water	45-50	aquaporin 4	Homo sapiens	12-16
21895970-6	2012	Tap water cannot keep cells viable as well as other solutions.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
21939365-0	2012	Determination of parathion, aldicarb, and thiobencarb in tap water and bottled mineral water in Mashhad, Iran.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
21939365-6	2012	In this study, we determined the concentration of three pesticides (aldicarb, parathion, and thiobencarb) in 13 tap-water samples collected from 13 different urban areas and 10 samples of bottled mineral water in Mashhad, a major city in northeast Iran.	Water	116-121	nuclear RNA export factor 1	Homo sapiens	112-115
21939365-8	2012	Results showed that 2 of 13 tap-water samples and 2 of 10 bottled mineral water trademarks were contaminated either by parathion or by thiobencarb or both, with concentrations ranging between 0.6 and 0.8 ppb.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
28539779-2	2012	It is caused by antibodies that attack aquaporin 4 water channels in the cell membrane of astrocytic foot processes at the blood brain barrier.	Water	51-56	aquaporin 4	Homo sapiens	39-50
22169679-5	2012	In order to make the correlation between radon and radium concentrations in the tap water and in the water from public drinking fountain, the gamma-spectrometric measurements were performed.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
22253429-7	2012	BDNF levels were measured by ELISA at 3 or 7 d after birth in different regions of the brains of rats exposed to propylthiouracil (PTU) in the drinking water.	Water	152-157	brain-derived neurotrophic factor	Rattus norvegicus	0-4
22331819-0	2012	Dummy molecularly imprinted polymers as the coating of stir bar for sorptive extraction of bisphenol A in tap water.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	106-109
22331819-9	2012	The method was applied to the determination of trace bisphenol A in tap water.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
23066186-4	2012	Optimized batch (ME-1) was selected having 5% Capmul MCM, 50% Tween 20:PEG 400 and 45% water based on evaluation parameters globule size, zeta potential, PDI, % transmittance.	Water	87-92	malic enzyme 1	Homo sapiens	17-21
22285091-9	2012	Nickel exposure via drinking water was derived from databases on Ni tap water quality.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	68-71
22285091-10	2012	A small proportion of the EU population (&lt;5%) is likely to be exposed to tap water exceeding the EU standard (20 mug Ni/l).	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
22196879-5	2012	Good linearity for all calibration curves was obtained, and the limit of detection (LOD) for BPA was 0.4 ng/mL in tap water.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
22226717-4	2012	Whereas TNT degradation occurred under both aerobic and anaerobic conditions, RDX and HMX degradation occurred only when water content conditions resulted in a prolonged period of negative redox potential.	Water	121-126	radixin	Homo sapiens	78-81
22257032-2	2012	GGT catalyzes the cleavage of gamma-glutamyl donor substrates and the transfer of the gamma-glutamyl moiety to an amine of an acceptor substrate or water.	Water	148-153	inactive glutathione hydrolase 2	Homo sapiens	0-3
21934603-3	2012	We have shown for the first time that a water-soluble extract of taro (TE) potently inhibits lung-colonizing ability and spontaneous metastasis from mammary gland-implanted tumors, in a murine model of highly metastatic estrogen receptor, progesterone receptor and Her-2/neu-negative breast cancer.	Water	40-45	progesterone receptor	Mus musculus	239-260
22121121-8	2012	The dianion is especially prone to strong hydrogen-bonding interactions with trace water present in the organic solvents, resulting in a shift in the formal reduction potential of E(2) to more positive potentials as more water is added to the solvent.	Water	83-88	cystatin 12, pseudogene	Homo sapiens	180-184
22121121-8	2012	The dianion is especially prone to strong hydrogen-bonding interactions with trace water present in the organic solvents, resulting in a shift in the formal reduction potential of E(2) to more positive potentials as more water is added to the solvent.	Water	221-226	cystatin 12, pseudogene	Homo sapiens	180-184
22208532-7	2012	The CYP2A6 and CYP2E1 active sites are deeply buried, with access paths that are narrower than the radius of a water molecule.	Water	111-116	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	4-10
24626042-4	2012	The paper focuses on the study of c33, which provides a unique, fast, and noninvasive ultrasonic method to determine leaf elasticity and leaf water content.	Water	142-147	CD82 molecule	Homo sapiens	34-37
21643824-1	2012	The last decade has seen an increasing trend in consumer preference of bottled water over tap water.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
21643824-2	2012	Little is known what type of water children and adolescents prefer for drinking and what their parents think of their community tap water.	Water	132-137	nuclear RNA export factor 1	Homo sapiens	128-131
22629981-1	2012	We report a direct printing method, water-mediated metal transfer printing (mTP), for generating Ag patterns with a wide range of feature sizes.	Water	36-41	lysosomal-associated protein transmembrane 4A	Mus musculus	76-79
22629981-2	2012	Water-mediated mTP is based on the direct transfer of a metal thin film from a stamp to a substrate via a water-mediated surface bonding.	Water	0-5	lysosomal-associated protein transmembrane 4A	Mus musculus	15-18
22629981-2	2012	Water-mediated mTP is based on the direct transfer of a metal thin film from a stamp to a substrate via a water-mediated surface bonding.	Water	106-111	lysosomal-associated protein transmembrane 4A	Mus musculus	15-18
22629981-4	2012	To demonstrate its usefulness, we used the water-mediated mTP to fabricate low voltage ZnO thin-film transistors.	Water	43-48	lysosomal-associated protein transmembrane 4A	Mus musculus	58-61
22051897-8	2012	Protein levels of eNOS were repressed in L-NAME-only-treated rats, but were elevated in the descending aorta of rats administered captopril, K+ water and Acer okamotoanum sap (25, 50 and 100%) up to the level of the sham group provided commercial spring water, and then injected with dimethyl sulfoxide for the same period of time.	Water	144-149	nitric oxide synthase 3	Rattus norvegicus	18-22
22051897-8	2012	Protein levels of eNOS were repressed in L-NAME-only-treated rats, but were elevated in the descending aorta of rats administered captopril, K+ water and Acer okamotoanum sap (25, 50 and 100%) up to the level of the sham group provided commercial spring water, and then injected with dimethyl sulfoxide for the same period of time.	Water	254-259	nitric oxide synthase 3	Rattus norvegicus	18-22
22248025-10	2012	The slg1 mutant also has an increased expression of genes involved in the alternative respiratory pathway, which may compensate for the disrupted function of complex I and help scavenge the excess accumulation of H(2) O(2).	Water	213-219	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	4-8
22404225-3	2012	In this work, we perform 20 ns molecular dynamics (MD) simulations of the beta2AR-Gs protein complex with its agonist in an explicit lipid and water environment to investigate the activation mechanism of beta2AR.	Water	143-148	adrenoceptor beta 2	Homo sapiens	74-81
22339396-2	2012	Particular focus was on the crystallization of the fats around water droplets in the W/O emulsion systems using food emulsifiers of polyglycerol polyricinoleate (PGPR) alone (PGPR emulsion), and PGPR and monobehenoylglycerol (MB) (PGPR+MB emulsion).	Water	63-68	chromosome 10 open reading frame 90	Homo sapiens	51-55
22205228-11	2012	Thus we propose that structural or functional loss of cilia leads to abnormal trafficking of AQP2/V2R leading to enhanced salt and water absorption.	Water	131-136	arginine vasopressin receptor 2	Mus musculus	98-101
21892761-0	2012	Occurrence and sources of bromate in chlorinated tap drinking water in Metropolitan Manila, Philippines.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	49-52
21892761-1	2012	Significant levels of potentially carcinogenic bromate were measured in chlorinated tap drinking water in Metropolitan Manila, Philippines, using an optimized ion-chromatographic method.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	84-87
21892761-3	2012	The concentration of bromate in tap drinking water samples collected from 21 locations in cities and municipalities within the 9-month study period ranged from 7 to 138 mug l-1.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	32-35
22730938-3	2012	The objective of the study was to estimate the proportion of Perth metropolitan year two public primary school children drinking tap water at home, school and play.	Water	133-138	nuclear RNA export factor 1	Homo sapiens	129-132
22730938-4	2012	It also aimed to explore knowledge and attitudes that children and parents have towards drinking tap water, bottled water, fruit juices and soft drinks.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
22730938-7	2012	RESULTS: Forty-two per cent of the children in our study reported if thirsty they drank tap (fluoridated) water at home whereas parents stated 60% of children drank tap water at home.	Water	169-174	nuclear RNA export factor 1	Homo sapiens	165-168
22177529-5	2012	In 2 units of one hospital site, 100% of the samples of tap-water were positive, with high concentrations of Fusarium spp.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
22256961-9	2012	In chicken juice and tap water models spiked with known quantities of Camp.	Water	25-30	cathelicidin-2	Gallus gallus	70-74
21741124-4	2012	We found that Fyn(+/-)3xTg(+/-) mice had increased soluble and intracellular Abeta, and these changes were accompanied by impaired performance on the Morris water maze at 18 months.	Water	157-162	Fyn proto-oncogene	Mus musculus	14-17
22373667-8	2012	alpha-Syn-ZF embryos developed severe deformities due to neuronal apoptosis and most of them died within 48 to 72 h. CLR01 added to the water significantly improved zebrafish phenotype and survival, suppressed alpha-syn aggregation in neurons, and reduced alpha-syn-induced apoptosis.	Water	136-141	synemin	Homo sapiens	6-9
22365757-5	2012	Our final model of the CXCR4-FC131 complex is partially different from the X-ray crystal structure of CXCR4-CVX15 and suggests water-mediated interactions.	Water	127-132	C-X-C motif chemokine receptor 4	Homo sapiens	23-28
22365757-5	2012	Our final model of the CXCR4-FC131 complex is partially different from the X-ray crystal structure of CXCR4-CVX15 and suggests water-mediated interactions.	Water	127-132	C-X-C motif chemokine receptor 4	Homo sapiens	102-107
22326022-6	2012	Here we show that increasing cytoplasmic osmolarity through a genetic lesion known to produce elevated levels of soluble sugars, exogenously providing osmolytes in the growth media, or withholding water rescues the msl2-1 msl3-1 leaf epidermal plastid phenotype, producing plastids that resemble the wild-type in shape and size.	Water	197-202	MSCS-like 3	Arabidopsis thaliana	222-226
22265775-2	2012	The procedure is based on transforming a water-soluble IL-based surfactant, 1-hexadecyl-3-butylimidazolium bromide (C16C4Im-Br), into a water-insoluble IL, 1-hexadecyl-3-butylimidazolium bis[(trifluoromethane)sulfonyl]imide (C16C4Im-NTf2), via a simple metathesis reaction.	Water	136-141	nuclear transport factor 2	Homo sapiens	233-237
22130631-1	2012	BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO).	Water	206-211	glutathione peroxidase 1	Homo sapiens	168-192
22130631-1	2012	BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO).	Water	206-211	glutathione peroxidase 1	Homo sapiens	194-199
22139469-0	2012	Analysis of UV filters in tap water and other clean waters in Spain.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
22139469-4	2012	The optimized methodology was applied to perform the first survey of UV absorbing compounds in tap water from the metropolitan area and the city of Barcelona (Catalonia, Spain).	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
22834255-4	2012	The possible negative effect of chlorinated water disinfection byproducts, present in hot water on the population"s health is considered in detail.	Water	44-49	alcohol dehydrogenase iron containing 1	Homo sapiens	86-89
22282469-11	2012	Similarly, in vivo uterine suppression of Sik-SP also caused inhibition of epithelial cell proliferation and aberrant prolongation of water imbibition in the late phase by E2.	Water	134-139	NOP58 ribonucleoprotein	Mus musculus	42-48
22822413-9	2012	We found that brain water content in the ipsilateral caudate was higher (p&lt;0.05) in rats injected with iron+Abeta than with iron, Abeta or saline.	Water	20-25	amyloid beta precursor protein	Rattus norvegicus	111-116
22822413-9	2012	We found that brain water content in the ipsilateral caudate was higher (p&lt;0.05) in rats injected with iron+Abeta than with iron, Abeta or saline.	Water	20-25	amyloid beta precursor protein	Rattus norvegicus	133-138
22154495-1	2012	Proton localized NMR spectroscopy (MRS) has been applied to study the diffusion of three small molecules, caffeine, theophylline and caprolactam, in chitosan gels with different concentration of water.	Water	195-200	MROS	Homo sapiens	35-38
22191625-11	2012	Boiling water effectively removed phthalate esters from tap water.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	56-59
22191625-11	2012	Boiling water effectively removed phthalate esters from tap water.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
22134495-2	2012	Tri-n-butylphosphate (TBP) was used as extractant, thus avoiding the use of toxic water-immiscible chlorinated solvents.	Water	82-87	TATA-box binding protein	Homo sapiens	22-25
22307776-3	2012	This polarity is characterized by the uneven distribution of the water channel protein aquaporin-4 (AQP4), dystroglycan and other molecules.	Water	65-70	aquaporin 4	Homo sapiens	87-98
22307776-3	2012	This polarity is characterized by the uneven distribution of the water channel protein aquaporin-4 (AQP4), dystroglycan and other molecules.	Water	65-70	aquaporin 4	Homo sapiens	100-104
22305388-0	2012	Nontuberculous mycobacteria in tap water.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
21670987-6	2012	Toyama ground, spring, and tap water were all the same type of water mass, called Ca-HCO(3).	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
21670987-8	2012	Trace levels of As, Cd, Cr, Co, Cu, Fe, Pb, Mn, Mo, Ni, V, Zn, Sr, and Hg were detected in ground, spring, and tap water sources using inductively coupled plasma atomic emission spectrometry, and their levels were below WHO and Japanese water quality standard limits.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
21670987-10	2012	Total trihalomethanes (THMs) were the major contaminant detected in all natural drinking water sources, but the concentration was highest in tap water (37.27 +- 0.05 mug/L).	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
21281561-2	2012	A growing body of evidence indicates that water channel aquaporin-4 (AQP4) is a potential molecular target for the regulation astrocyte function.	Water	42-47	aquaporin 4	Mus musculus	69-73
22076914-4	2012	The strength of coupling depends on the local electron-vibration intra-tissue molecular environment and the amount of polar solvent water surrounding the net charges on collagen, elastin, and tryptophan.	Water	132-137	elastin	Homo sapiens	179-186
21621005-10	2012	This antibody recognizes aquaporin-4, which represents the most abundant water channel of the central nervous system.	Water	73-78	aquaporin 4	Homo sapiens	25-36
22008857-12	2012	On the basis of this study, a kinetic model is proposed to describe the inhibition of HSL by compound 7600 in the aqueous phase as well as its partial reactivation at the lipid-water interface.	Water	177-182	lipase E, hormone sensitive type	Homo sapiens	86-89
23209525-3	2012	The relative configuration of a new isomer of tropinone aldol accessible synthetically through the direct solventless reaction of tropinone and benzaldehyde in the presence of water was determined as exo,syn by comparison of NMR data of the aldol isomers, in particular vicinal coupling constants and shifts corresponding to the side-chain CH group, with data of related TBDMS derivatives and confirmed by single-crystal X-ray diffraction.	Water	176-181	synemin	Homo sapiens	73-76
21745799-4	2012	Aquaporin-5 was present at the apical face of the olfactory epithelium, completing a water transport pathway to the surface of the epithelium.	Water	85-90	aquaporin 5	Rattus norvegicus	0-11
22894115-8	2012	The produced CnF2n+1* reacted with H2O, forming CnF2n+1OH, then CnF2n+1OH underwent HF loss and hydrolysis to form CnF2n+1COOH.	Water	35-38	NPHS1 adhesion molecule, nephrin	Homo sapiens	48-51
22894115-8	2012	The produced CnF2n+1* reacted with H2O, forming CnF2n+1OH, then CnF2n+1OH underwent HF loss and hydrolysis to form CnF2n+1COOH.	Water	35-38	NPHS1 adhesion molecule, nephrin	Homo sapiens	48-51
21932005-7	2012	The proposed method has been successfully used for the determination of homocysteine in the real sample (blood serum and tap water) matrix.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
22200949-7	2012	Remarkably, CALI-induced reduction in AQP4-KR water permeability was approximately twice as efficient for the aggregate-forming M23 isoform; this suggests intermolecular CALI, which was confirmed by native gel electrophoresis on cells coexpressing M23-AQP4-KR and myc-tagged M23-AQP4.	Water	46-51	aquaporin 4	Homo sapiens	38-42
22264543-2	2012	AQP4 is involved in brain water balance, neuroexcitation, astrocyte migration, and neuroinflammation and is the target of pathogenic autoantibodies in neuromyelitis optica.	Water	26-31	aquaporin 4	Homo sapiens	0-4
21969089-3	2012	mkkk20 mutants were found to be sensitive to high concentration of salt and showed higher water loss rates than wild-type (WT) plants under dehydration conditions.	Water	90-95	mitogen-activated protein kinase kinase kinase 20	Arabidopsis thaliana	0-6
22128336-1	2012	The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in a spectrum of relapsing autoimmune inflammatory central nervous system disorders of varying severity that is unified by detection of the serum biomarker neuromyelitis optica (NMO)-IgG.	Water	34-39	aquaporin 4	Homo sapiens	15-26
22128336-1	2012	The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in a spectrum of relapsing autoimmune inflammatory central nervous system disorders of varying severity that is unified by detection of the serum biomarker neuromyelitis optica (NMO)-IgG.	Water	34-39	aquaporin 4	Homo sapiens	28-32
21899995-2	2012	The ethanolic extract of Danshen roots (containing mainly tanshinones) inhibited CYP1A2-catalyzed phenacetin O-deethylation (IC(50)=24.6 mug/ml) in primary rat hepatocytes while the water extract containing mainly salvianolic acid B and danshenshu had no effect.	Water	182-187	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	81-87
2607010-1	1989	Drinking bottled water has become a popular substitute for tap water because of the concern over the contamination of municipal water supplies.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
22138430-9	2012	Hence, AQP4 may play an important role in water distribution in the teleost fish retina.	Water	42-47	aquaporin 4	Homo sapiens	7-11
22666476-3	2012	It was reported that TDT 067 (a topical formulation of 15 mg/ml terbinafine in Transfersome  vesicles) has a much more potent antifungal activity in vitro compared with conventional terbinafine, which is a water-insoluble fungicide.	Water	206-211	DNA nucleotidylexotransferase	Homo sapiens	21-24
2607010-1	1989	Drinking bottled water has become a popular substitute for tap water because of the concern over the contamination of municipal water supplies.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
22590566-1	2012	Aquaporin-4 (AQP4), the main water channel of the brain, is highly expressed in animal glioma and human glioblastoma in situ.	Water	29-34	aquaporin 4	Homo sapiens	0-11
2564894-6	1989	These observations suggested that esters at C-2" and/or C-7, which would tend to promote water solubility, might serve as useful prodrugs of taxol.	Water	89-94	complement C7	Homo sapiens	56-59
22590566-1	2012	Aquaporin-4 (AQP4), the main water channel of the brain, is highly expressed in animal glioma and human glioblastoma in situ.	Water	29-34	aquaporin 4	Homo sapiens	13-17
22642069-7	2012	Contribution of tap water in the intake of calcium and magnesium depended on the contents of these minerals in water, and amounted from 6,0% (&lt; or = 68,3 mg calcium on dm3 water--1st quartile) to 14,8% (&gt; 112 mg/dm3--4th quartile) for calcium and from 2,9% (&lt; or = 10,9 mg/dm3) to 4,7% (&gt; 15,4 mg/dm3) for magnesium.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
22113212-3	2012	The osmotic water permeability (Pf) for GLUT3 or GLUT1 increased significantly compared with that for oocytes-injected water.	Water	12-17	solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog	Xenopus laevis	49-54
21993530-0	2012	Rhcg1 and NHE3b are involved in ammonium-dependent sodium uptake by zebrafish larvae acclimated to low-sodium water.	Water	110-115	solute carrier family 9 member A3, tandem duplicate 2	Danio rerio	10-15
22642069-7	2012	Contribution of tap water in the intake of calcium and magnesium depended on the contents of these minerals in water, and amounted from 6,0% (&lt; or = 68,3 mg calcium on dm3 water--1st quartile) to 14,8% (&gt; 112 mg/dm3--4th quartile) for calcium and from 2,9% (&lt; or = 10,9 mg/dm3) to 4,7% (&gt; 15,4 mg/dm3) for magnesium.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	16-19
2523076-0	1989	Water intake in rats subjected to hypothalamic immunoneutralization of angiotensin II, atrial natriuretic peptide, vasopressin, or oxytocin.	Water	0-5	natriuretic peptide A	Rattus norvegicus	87-113
22642069-7	2012	Contribution of tap water in the intake of calcium and magnesium depended on the contents of these minerals in water, and amounted from 6,0% (&lt; or = 68,3 mg calcium on dm3 water--1st quartile) to 14,8% (&gt; 112 mg/dm3--4th quartile) for calcium and from 2,9% (&lt; or = 10,9 mg/dm3) to 4,7% (&gt; 15,4 mg/dm3) for magnesium.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	16-19
22642069-9	2012	Comparing the average content of minerals in non-boiled and boiled tap water the cooking process influenced the levels of calcium (95,8 +/- 31,8 vs 89,7 +/- 31,1 mg/dm3), magnesium (12,1 +/- 3,24 vs. 12,7 +/- 3,04 mg/dm3), zinc (0,35 +/- 0,87 vs. 0,17 +/- 0,89 mg/dm3), potassium (3,31 +/- 2,67 vs. 3,66 +/- 4,18 mg/dm3) and sodium (23,2 +/- 15,4 vs. 25,9 +/- 17,2 mg/dm3).	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
22218475-2	2012	Aquaporin-4 antibody is positive in a high percentage of NMO patients and it is directed against this water channel richly expressed on foot processes of astrocytes.	Water	102-107	aquaporin 4	Homo sapiens	0-11
2923913-1	1989	Oral administration of D-aspartate to mice for 2 weeks by addition of the amino acid to drinking water produced a nearly 4-fold increase in liver D-aspartate oxidase (EC 1.4.3.1) activity, whereas no increase was induced by L-aspartate administered in the same way.	Water	97-102	D-aspartate oxidase	Mus musculus	146-165
22957282-12	2012	Interestingly, the patient admitted using tap water occasionally for mixing heroin when her sterile water ran out, which we thought was the likely source of M. fortuitum.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
22957282-12	2012	Interestingly, the patient admitted using tap water occasionally for mixing heroin when her sterile water ran out, which we thought was the likely source of M. fortuitum.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	42-45
22761987-2	2012	We simulate the classic ST2 model of water for times up to 1000 ns and system size up to N = 729.	Water	37-42	ST2	Homo sapiens	24-27
22649292-4	2012	Most of the selected minerals found in the tap water samples were below the international standard limits, except for iron and manganese.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
22649292-5	2012	The concentrations of iron and manganese in the tap water samples were higher than the standard limits, which were obtained from one and three of the studied locations, respectively.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
2706314-0	1989	Solvated helical backbones: x-ray diffraction study of Boc-Ala-Leu-Aib-Ala-Leu-Aib-OMe.H2O.	Water	87-90	ANIB1	Homo sapiens	67-70
22619572-3	2012	A method was proposed to downscale crop coefficient and water requirement from growing stage to substage scales, which is based on the interpolation of accumulated crop and reference evapotranspiration calculated from their values in growing stages.	Water	56-61	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	164-168
22292807-4	2012	Moreover, astrocytes control water flux at BBB site by expressing a specific water channel, namely aquaporin-4 (AQP4), involved in the molecular composition of the orthogonal particles arrays (OAPs) on the perivascular glial endfeet and tightly coupled with the maintenance of the BBB integrity.	Water	29-34	aquaporin 4	Homo sapiens	99-110
22292807-4	2012	Moreover, astrocytes control water flux at BBB site by expressing a specific water channel, namely aquaporin-4 (AQP4), involved in the molecular composition of the orthogonal particles arrays (OAPs) on the perivascular glial endfeet and tightly coupled with the maintenance of the BBB integrity.	Water	29-34	aquaporin 4	Homo sapiens	112-116
22292807-4	2012	Moreover, astrocytes control water flux at BBB site by expressing a specific water channel, namely aquaporin-4 (AQP4), involved in the molecular composition of the orthogonal particles arrays (OAPs) on the perivascular glial endfeet and tightly coupled with the maintenance of the BBB integrity.	Water	77-82	aquaporin 4	Homo sapiens	99-110
22292807-4	2012	Moreover, astrocytes control water flux at BBB site by expressing a specific water channel, namely aquaporin-4 (AQP4), involved in the molecular composition of the orthogonal particles arrays (OAPs) on the perivascular glial endfeet and tightly coupled with the maintenance of the BBB integrity.	Water	77-82	aquaporin 4	Homo sapiens	112-116
23339938-0	2012	The prevalence, isolation and morphotyping of potentially pathogenic free-living amoebae from tap water and environmental water sources in Sivas.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
2706314-0	1989	Solvated helical backbones: x-ray diffraction study of Boc-Ala-Leu-Aib-Ala-Leu-Aib-OMe.H2O.	Water	87-90	ANIB1	Homo sapiens	79-82
2706314-1	1989	A second example of insertion of a water molecule into the helical backbone of an apolar peptide is presented here and compared to a similar occurrence in a longer peptide with the same type of sequence of residues, i.e., Boc-Aib-(Ala-Leu-Aib)3-OMe.	Water	35-40	ANIB1	Homo sapiens	226-229
2706314-1	1989	A second example of insertion of a water molecule into the helical backbone of an apolar peptide is presented here and compared to a similar occurrence in a longer peptide with the same type of sequence of residues, i.e., Boc-Aib-(Ala-Leu-Aib)3-OMe.	Water	35-40	ANIB1	Homo sapiens	239-242
23109596-3	2012	They have been found in surface water and tap water in both developed and developing countries around the world including in North America, Europe and Asia.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
23109596-4	2012	In most countries, rivers are the source of tap water, which is one of the important pathways in which PFCs reach humans.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
2541297-9	1989	These results may reflect the differences in the amount of water binding sites of the elastin which is involved in the elasticity of the carotid wall at low extension.	Water	59-64	elastin	Homo sapiens	86-93
23093956-14	2012	DGI is a nonserious, late onset, and easily treated complication of PAAG that is probably induced due to water exchange between gel and surrounding tissue and modest host immune reaction to gel.	Water	105-110	desmoglein 1	Homo sapiens	0-3
2536699-3	1989	Treatment of the (Sp,Sp)-stereoisomer with cyanogen bromide in [18O]water leads to substitution of sulfur by 18O with predominant retention of configuration at P1 and P4. (Sp,Sp)-P1,P4-Bis(5"-adenosyl)-1[thio-18O2],4[thio-18O2]tetraphosphate was synthesized and on treatment with cyanogen bromide in [17O]water gave (Rp,Rp)-P1,P4-bis(5"-adenosyl)-1[17O,18O2],4[17O,18O2]tetraphosphate.	Water	68-73	crystallin gamma F, pseudogene	Homo sapiens	160-170
22452190-4	2012	When the leakage-proof barrier is set in the bottom of water table aquifer, the concentration of Cr6+ is higher than that the leakage-proof barrier is unset, but the result is just opposite when setting the leakage-proof barrier in the bottom of underlying aquifer.	Water	55-60	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	97-100
21937340-7	2012	The results show that the Debye model algorithm is of most importance in the tap water for a bandwidth of more than 1.5 GHz.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
2536699-3	1989	Treatment of the (Sp,Sp)-stereoisomer with cyanogen bromide in [18O]water leads to substitution of sulfur by 18O with predominant retention of configuration at P1 and P4. (Sp,Sp)-P1,P4-Bis(5"-adenosyl)-1[thio-18O2],4[thio-18O2]tetraphosphate was synthesized and on treatment with cyanogen bromide in [17O]water gave (Rp,Rp)-P1,P4-bis(5"-adenosyl)-1[17O,18O2],4[17O,18O2]tetraphosphate.	Water	305-310	crystallin gamma F, pseudogene	Homo sapiens	160-170
2568061-0	1989	Treatment of hyperhidrosis manuum by tap water iontophoresis.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
23028218-5	2012	It was found that LCST of the hydrogel increased significantly with the increasing NIPAAm content, and hydrogel with higher AAc/HEMAPCL ratio exhibited better storage modulus, water content, and injectability.	Water	176-181	glycine-N-acyltransferase	Homo sapiens	124-127
2568061-1	1989	In a randomised, double-blind, controlled clinical trial of the effect of treatment with tap water iontophoresis, 11 patients with palmar hyperhidrosis were treated actively on one hand and with placebo on the other.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
23022848-3	2012	METHODS: We studied blood samples collected from 36 consecutive patients diagnosed with pesticides poisoning and 36 tap drinking water (surface and ground).	Water	129-134	nuclear RNA export factor 1	Homo sapiens	116-119
22643425-0	2012	Water quality as an indicator of hydrogeological conditions: a case study of the Belgrade Groundwater Source (Sava/Danube confluence area).	Water	0-5	T-box transcription factor T	Homo sapiens	110-114
2521430-1	1989	Atrial natriuretic factor (ANF) is a peptide hormone that causes a large increase in urinary sodium chloride and water excretion when its plasma concentration rises above basal levels.	Water	113-118	natriuretic peptide A	Rattus norvegicus	0-25
22174728-2	2012	In this proof-of-principle study, we sought to measure the release of potentially toxic elements from ionic footbaths into distilled and tap water with and without feet.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	137-140
2521430-1	1989	Atrial natriuretic factor (ANF) is a peptide hormone that causes a large increase in urinary sodium chloride and water excretion when its plasma concentration rises above basal levels.	Water	113-118	natriuretic peptide A	Rattus norvegicus	27-30
22264543-1	2012	Aquaporin-4 (AQP4) is a water channel expressed in astrocytes throughout the central nervous system, as well as in epithelial cells in various peripheral organs.	Water	24-29	aquaporin 4	Homo sapiens	0-11
22264543-1	2012	Aquaporin-4 (AQP4) is a water channel expressed in astrocytes throughout the central nervous system, as well as in epithelial cells in various peripheral organs.	Water	24-29	aquaporin 4	Homo sapiens	13-17
21896286-6	2011	The benefit of lowering the systemic oxidative stress by pristane in the course of EAU was confirmed by injecting the antioxidant NAC in IRBP-immunized mice.	Water	83-86	NLR family, pyrin domain containing 1A	Mus musculus	130-133
2521430-7	1989	If ANF has a similar action on the cortical collecting duct in vivo, it could account for a substantial part of the ANF-mediated increase in urinary sodium and water excretion.	Water	160-165	natriuretic peptide A	Rattus norvegicus	3-6
2521430-7	1989	If ANF has a similar action on the cortical collecting duct in vivo, it could account for a substantial part of the ANF-mediated increase in urinary sodium and water excretion.	Water	160-165	natriuretic peptide A	Rattus norvegicus	116-119
22282586-6	2011	These results suggest the following possibilities: 1) FS cells especially require water for their functions and 2) transepithelial water transfer could occur between the lumen of Rathke"s residual pouch and the interstitial fluid in the adenohypophysis through the AQP4 and AQP5 channels in the marginal layer cells.	Water	131-136	aquaporin 5	Rattus norvegicus	274-278
2589637-2	1989	The volume density (Vv) of atrial granules, which contain atrial natriuretic peptide (ANP), displayed a 135%-rise in water/sodium-restricted animals.	Water	117-122	natriuretic peptide A	Rattus norvegicus	58-84
22438854-2	2011	Ang-(1-7) is present in the kidneys at concentrations comparable to those of Ang II and is associated with vasodilation, modulation of sodium and water transport, and stimulation of nitric oxide (NO) synthase.	Water	146-151	angiogenin	Rattus norvegicus	0-8
22359497-0	2012	The role of conserved waters in conformational transitions of Q61H K-ras.	Water	22-28	KRAS proto-oncogene, GTPase	Homo sapiens	67-72
22359497-1	2012	To investigate the stability and functional role of long-residence water molecules in the Q61H variant of the signaling protein K-ras, we analyzed all available Ras crystal structures and conformers derived from a series of independent explicit solvent molecular dynamics (MD) simulations totaling 1.76 micros.	Water	67-72	KRAS proto-oncogene, GTPase	Homo sapiens	128-133
2589637-2	1989	The volume density (Vv) of atrial granules, which contain atrial natriuretic peptide (ANP), displayed a 135%-rise in water/sodium-restricted animals.	Water	117-122	natriuretic peptide A	Rattus norvegicus	86-89
2583176-5	1989	In these conditions Tsk = 28.125 + 0.021 Pw + 0.210 Ta (Pw: ambient water vapour pressure in mb).	Water	68-73	tsukushi, small leucine rich proteoglycan	Homo sapiens	20-23
23119059-3	2012	METHODS: EAU was induced in B10RIII mice by immunization with interphotoreceptor retinoid-binding protein peptide 161-180 (IRBP(161-180)).	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	123-127
21952128-0	2011	D184E mutation in aquaporin-4 gene impairs water permeability and links to deafness.	Water	43-48	aquaporin 4	Homo sapiens	18-29
21952128-5	2011	A BLAST analysis revealed that the amino acid D184 is conserved across species, consistently with a crucial role in the structure/function of AQP4 water channels.	Water	147-152	aquaporin 4	Homo sapiens	142-146
2910739-0	1989	Occurrence of platelet-activating factor (PAF) in normal rat stomach and alteration of PAF level by water immersion stress.	Water	100-105	PCNA clamp associated factor	Rattus norvegicus	87-90
21922099-2	2011	The synergy of glutathione (GSH), dithiothreitol (DTT) and N-acetyl-L-cysteine (NAC) mixed SAMs enhanced the detection specificity and sensitivity of As(III) in water samples, resulting from the immobilization of a large number of As(III) moieties on the gold electrode surface via As-O and As-S linkages.	Water	161-166	X-linked Kx blood group	Homo sapiens	80-83
22067168-6	2011	The average tau(CARS) for the intracellular H(2)O/D(2)O exchange in the AQP4-EGFP-HeLa S3 cells was 43.1 +- 15.8 ms. We also assessed the cell volume and the cell surface area to calculate P(d).	Water	44-49	aquaporin 4	Homo sapiens	72-76
23056199-3	2012	Moreover, this work shows that hydrogen bonding to the non-reducing ring O5" oxygen is shared between water and the HO3 hydroxyl group with an average of 50% occupancy by each hydrogen-bond donor.	Water	102-107	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	116-119
22808259-1	2012	BACKGROUND: Aquaporin3 (AQP3) and Aquaporin4 (AQP4) play a major role in transcellular and transepithelial water movement as water channel membrane proteins.	Water	107-112	aquaporin 4	Homo sapiens	34-44
22067168-8	2011	AQP4-mediated water diffusion was independent of the temperature but was dependent on the expression level of the protein at the plasma membrane.	Water	14-19	aquaporin 4	Homo sapiens	0-4
22808259-1	2012	BACKGROUND: Aquaporin3 (AQP3) and Aquaporin4 (AQP4) play a major role in transcellular and transepithelial water movement as water channel membrane proteins.	Water	107-112	aquaporin 4	Homo sapiens	46-50
2910739-4	1989	The stomach PAF level was significantly altered by water immersion stress.	Water	51-56	PCNA clamp associated factor	Rattus norvegicus	12-15
2925540-5	1989	The reduction of body fat content (g/kg) elicited by pGH was 22, 36 and 33% for boars, gilts and barrows, respectively, with a corresponding increase (P less than .01) of body protein and water content.	Water	188-193	somatotropin	Sus scrofa	53-56
22438957-10	2012	RESULTS: LBP pre-treatment significantly improved neurological deficits as well as decreased infarct size, hemispheric swelling, and water content.	Water	133-138	lipopolysaccharide binding protein	Mus musculus	9-12
21820401-1	2011	Cytochrome c (Cc) and cytochrome c peroxidase (CcP) form a physiological complex in the inter-membrane space of yeast mitochondria, where CcP reduces hydrogen peroxide to water using the electrons provided by ferrous Cc.	Water	171-176	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	22-45
21820401-1	2011	Cytochrome c (Cc) and cytochrome c peroxidase (CcP) form a physiological complex in the inter-membrane space of yeast mitochondria, where CcP reduces hydrogen peroxide to water using the electrons provided by ferrous Cc.	Water	171-176	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	47-50
21820401-1	2011	Cytochrome c (Cc) and cytochrome c peroxidase (CcP) form a physiological complex in the inter-membrane space of yeast mitochondria, where CcP reduces hydrogen peroxide to water using the electrons provided by ferrous Cc.	Water	171-176	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	138-141
2488958-2	1989	ECG from the pacemaker implanted patients in the bathtub with tap water was recorded through three silver/silver chloride electrodes (4 x 4 cm) fitted on the inside wall of bathtub.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
22276499-3	2011	This study aimed to compare lead levels between untreated ground water and treated surface (tap) water in 18 different districts.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	92-95
2849934-3	1988	Bradykinin stimulated a rapid and parallel increase in approximately equivalent amounts of water soluble ([3H]choline plus [3H]phosphocholine) and lipid ([3H]phosphatidic acid plus [3H]diacylglycerol) phosphodiesteratic cleavage products of PC.	Water	91-96	kininogen 1	Bos taurus	0-10
22000761-8	2011	Estimated "dose" of atrazine and chlorotriazine from tap water was inversely related to mean mid-luteal estradiol metabolite.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
3233597-5	1988	Spectroscopic and other evidence suggested that the Mg(II) ion in the Mg(D-glucose)X2.4 H2O adducts six-coordinate, binding to a D-glucose molecule (possibly via O-1 and O-2 atoms) and to four H2O molecules, whereas, in the corresponding 1:1 Ca-D-glucose adduct, the Ca(II) ion is possibly seven-coordinate, binding to a sugar moiety (through the O-1, O-2, and other sugar donor atoms) and to four H2O molecules.	Water	88-91	immunoglobulin kappa variable 1D-39	Homo sapiens	129-173
22277409-2	2011	An antibody for aquaporin-4 (AQP4), which is a water channel located in astrocyte foot process, is specifically positive for NMO and antibody and complement dependent astrocytic damage is thought to be a main cause of NMO.	Water	47-52	aquaporin 4	Homo sapiens	16-27
22277409-2	2011	An antibody for aquaporin-4 (AQP4), which is a water channel located in astrocyte foot process, is specifically positive for NMO and antibody and complement dependent astrocytic damage is thought to be a main cause of NMO.	Water	47-52	aquaporin 4	Homo sapiens	29-33
3233597-5	1988	Spectroscopic and other evidence suggested that the Mg(II) ion in the Mg(D-glucose)X2.4 H2O adducts six-coordinate, binding to a D-glucose molecule (possibly via O-1 and O-2 atoms) and to four H2O molecules, whereas, in the corresponding 1:1 Ca-D-glucose adduct, the Ca(II) ion is possibly seven-coordinate, binding to a sugar moiety (through the O-1, O-2, and other sugar donor atoms) and to four H2O molecules.	Water	88-91	carbonic anhydrase 2	Homo sapiens	267-273
3233597-5	1988	Spectroscopic and other evidence suggested that the Mg(II) ion in the Mg(D-glucose)X2.4 H2O adducts six-coordinate, binding to a D-glucose molecule (possibly via O-1 and O-2 atoms) and to four H2O molecules, whereas, in the corresponding 1:1 Ca-D-glucose adduct, the Ca(II) ion is possibly seven-coordinate, binding to a sugar moiety (through the O-1, O-2, and other sugar donor atoms) and to four H2O molecules.	Water	88-91	immunoglobulin kappa variable 2D-40	Homo sapiens	347-355
21781979-8	2011	In the supraoptic nucleus (SON) of sham rats, water deprivation significantly increased Fos staining while water intake following dehydration prevented this increase.	Water	46-51	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	88-91
21781979-9	2011	Water deprivation significantly increased Fos staining in the SON of SLNX rats.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	42-45
21781979-10	2011	Following water intake after 46 h water deprivation in SLNX rats, Fos staining in the ipsilateral SON was significantly greater than the contralateral SON and significantly lower than 48 h water deprivation.	Water	10-15	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-69
3233597-6	1988	In 1:2 Ca(D-glucose)2X2.4 H2O, the calcium ion may be eight-coordinate, binding to two D-glucose molecules (possibly via the O-1 and O-2 atoms of each sugar moiety) and to four H2O molecules.	Water	26-29	immunoglobulin kappa variable 2D-40	Homo sapiens	125-136
21781979-10	2011	Following water intake after 46 h water deprivation in SLNX rats, Fos staining in the ipsilateral SON was significantly greater than the contralateral SON and significantly lower than 48 h water deprivation.	Water	34-39	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-69
21781979-10	2011	Following water intake after 46 h water deprivation in SLNX rats, Fos staining in the ipsilateral SON was significantly greater than the contralateral SON and significantly lower than 48 h water deprivation.	Water	34-39	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-69
2845807-1	1988	Atrial natriuretic factor (ANF) concentration in atria and plasma was investigated in relation to the density and affinity of renal glomerular ANF receptors during water deprivation and rehydration in the rat.	Water	164-169	natriuretic peptide A	Rattus norvegicus	0-25
21781979-11	2011	In the nucleus of the solitary tract (NTS) of sham rats, both water deprivation and water intake produced significant increases in Fos staining bilaterally compared to euhydrated controls.	Water	62-67	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	131-134
21781979-11	2011	In the nucleus of the solitary tract (NTS) of sham rats, both water deprivation and water intake produced significant increases in Fos staining bilaterally compared to euhydrated controls.	Water	84-89	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	131-134
21781979-12	2011	In SLNX rats, water deprivation significantly increased Fos in both ipsilateral and contralateral NTS that was not different from sham rats.	Water	14-19	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-59
21781979-13	2011	SLNX significantly decreased Fos staining in the ipsilateral NTS of rats given access to water after dehydration compared to the corresponding sham treated rats.	Water	89-94	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	29-32
21781979-15	2011	This suggests that the superior laryngeal nerve contributes to changes in Fos staining in the NTS and SON following water intake in dehydrated rats.	Water	116-121	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-77
2845807-2	1988	Immunoreactive (IR) ANF-(99-126) was lower during water deprivation (4.2 +/- 0.5 fmol/ml) than in normally hydrated animals (10 +/- 1.5 fmol/ml); NH2-terminal IR ANF-(1-98) was also lower in water-deprived rats (75 +/- 2.4 fmol/ml) than in the controls (708 +/- 105 fmol/ml).	Water	50-55	natriuretic peptide A	Rattus norvegicus	20-23
22022637-1	2011	Aquaporin 4 (AQP4), the most abundant isozyme of the water specific membrane transporter aquaporin family, has now been implicated to play a significant role in the pathogenesis of various disease processes of the nervous system from epilepsy to Alzheimer"s disease.	Water	53-58	aquaporin 4	Homo sapiens	0-11
2845807-2	1988	Immunoreactive (IR) ANF-(99-126) was lower during water deprivation (4.2 +/- 0.5 fmol/ml) than in normally hydrated animals (10 +/- 1.5 fmol/ml); NH2-terminal IR ANF-(1-98) was also lower in water-deprived rats (75 +/- 2.4 fmol/ml) than in the controls (708 +/- 105 fmol/ml).	Water	191-196	natriuretic peptide A	Rattus norvegicus	20-23
22022637-1	2011	Aquaporin 4 (AQP4), the most abundant isozyme of the water specific membrane transporter aquaporin family, has now been implicated to play a significant role in the pathogenesis of various disease processes of the nervous system from epilepsy to Alzheimer"s disease.	Water	53-58	aquaporin 4	Homo sapiens	13-17
2845807-4	1988	The renal glomerular ANF receptor population was greater in water-deprived animals than a control animals.	Water	60-65	natriuretic peptide A	Rattus norvegicus	21-24
2845807-6	1988	The renal glomerular ANF receptor population, which was markedly higher in water-deprived rats, gradually declined after rehydration, so that no difference was observed with the control group 24 h later.	Water	75-80	natriuretic peptide A	Rattus norvegicus	21-24
3052347-4	1988	Tap water had to be heated above 65 degrees C to reliably kill all bacterial enteropathogens.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
21882808-1	2011	A water-soluble pyrene-based butterfly shaped conjugated oligoelectrolyte (TFP) is synthesized and integrated with graphene oxide (GO) to form a label-free assay for heparin detection.	Water	2-7	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	75-78
2844855-9	1988	ANF appears to act at a site distal to cyclic AMP generation in the chain of events linking vasopressin receptor binding to an increase in osmotic water permeability.	Water	147-152	natriuretic peptide A	Rattus norvegicus	0-3
21999747-11	2011	In contrast, only one sample (out of six) of urban tap water from Budapest city was found to contain stanozolol, at a concentration of 1.19 pg/mL.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
3177220-2	1988	Exposure to 600 ppm CS2 only resulted in a decrease in hepatic cholesterol synthesis and an increase in the liver-to-body-weight ratio (relative liver weight); however, it caused no histopathological damage and had little or no consistent effect on the concentration of hepatic cholesterol or on hepatic water content.	Water	304-309	calsyntenin 2	Rattus norvegicus	20-23
21840380-0	2011	Anteroventral third ventricle (AV3V) lesion affects hypothalamic neuronal nitric oxide synthase (nNOS) expression following water deprivation.	Water	124-129	nitric oxide synthase 1	Rattus norvegicus	65-95
21840380-0	2011	Anteroventral third ventricle (AV3V) lesion affects hypothalamic neuronal nitric oxide synthase (nNOS) expression following water deprivation.	Water	124-129	nitric oxide synthase 1	Rattus norvegicus	97-101
3177220-4	1988	Exposure to 300 ppm CS2 + PB or to 600 ppm CS2 + PB resulted in a decrease in hepatic cholesterol synthesis and increases in the concentration of hepatic cholesterol, relative liver weight, hepatic water content, and histopathological damage.	Water	198-203	calsyntenin 2	Rattus norvegicus	20-23
21879121-2	2011	We report on a templating method used to deposit highly ordered nanoporous platinum (Pt)-doped tin dioxide (SnO(2)) thin films that are crystallized by a 100  C water vapor hydrothermal treatment, with the low temperature process being compatible with a large variety of substrates including plastic.	Water	161-166	strawberry notch homolog 2	Homo sapiens	108-111
3177220-4	1988	Exposure to 300 ppm CS2 + PB or to 600 ppm CS2 + PB resulted in a decrease in hepatic cholesterol synthesis and increases in the concentration of hepatic cholesterol, relative liver weight, hepatic water content, and histopathological damage.	Water	198-203	calsyntenin 2	Rattus norvegicus	43-46
3177220-6	1988	A concentration-response relationship also was demonstrated between exposure to CS2 in rats that had been treated with PB and decreased hepatic cholesterol synthesis, increased hepatic cholesterol concentration, increased relative liver weight, increased hepatic water content, and histopathological damage.	Water	263-268	calsyntenin 2	Rattus norvegicus	80-83
21866953-0	2011	Pd-catalytic in situ generation of H2O2 from H2 and O2 produced by water electrolysis for the efficient electro-fenton degradation of rhodamine B.	Water	67-72	relaxin 2	Homo sapiens	45-54
20539438-4	1988	Streak camera recordings of the emission from laser-induced plasmas were taken in distilled and tap water in controlled irradiation conditions.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
21741755-7	2011	In particular, a volume of 1.50 L of PET-bottled water required an extra virtual volume of 1.93 L of water while an extra 2.13 L was necessary to supply the same volume of tap water.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	172-175
21741755-9	2011	The WF of tap water was mainly due to losses of water during pipeline distribution and usage, while WF of bottled water was greatly influenced by the production of plastic materials.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
21741755-9	2011	The WF of tap water was mainly due to losses of water during pipeline distribution and usage, while WF of bottled water was greatly influenced by the production of plastic materials.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	10-13
2457622-2	1988	Hydrolysis of the internal thioester bond in native C3 is thought to be a key event in initiating the alternative pathway of C activation, because the resulting C3(H2O) acquires "C3b-like" properties.	Water	164-167	complement C3	Homo sapiens	179-182
21741755-9	2011	The WF of tap water was mainly due to losses of water during pipeline distribution and usage, while WF of bottled water was greatly influenced by the production of plastic materials.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	10-13
21968684-3	2011	Aquaporin-4 (AQP4) is a small integral membrane  protein that regulates water in the normal brain.	Water	72-77	aquaporin 4	Homo sapiens	0-11
21968684-3	2011	Aquaporin-4 (AQP4) is a small integral membrane  protein that regulates water in the normal brain.	Water	72-77	aquaporin 4	Homo sapiens	13-17
3185863-2	1988	The results show that 2 days of water deprivation does not affect methionine metabolism in the majority of the brain areas analyzed, but reveals selective increases in the hypothalamoneurohypophyseal system, in cerebral structures surrounding the third ventricle, in the locus ceruleus, raphe dorsalis, nucleus ambiguus and hippocampal CA3 layer.	Water	32-37	carbonic anhydrase 3	Rattus norvegicus	336-339
21856282-1	2011	Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system, where it has been reported to be involved in many pathophysiological roles including water transport.	Water	38-43	aquaporin 4	Homo sapiens	0-11
21856282-1	2011	Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system, where it has been reported to be involved in many pathophysiological roles including water transport.	Water	38-43	aquaporin 4	Homo sapiens	13-17
21856282-1	2011	Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system, where it has been reported to be involved in many pathophysiological roles including water transport.	Water	168-173	aquaporin 4	Homo sapiens	0-11
21856282-1	2011	Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system, where it has been reported to be involved in many pathophysiological roles including water transport.	Water	168-173	aquaporin 4	Homo sapiens	13-17
3135955-7	1988	A 0.5 or 0.25% supplement of alpha-difluoromethylornithine (alpha-DFMO) in the drinking water inhibited the induction of epidermal ODC following chrysarobin (220 nmol/mouse) treatment by 85 or 70%, respectively.	Water	88-93	ornithine decarboxylase, structural 1	Mus musculus	131-134
21856282-2	2011	In this paper, the AQP4 tetramer was modeled from its PDB structure file, embedded in a palmitoyl-oleoyl-phosphatidyl-choline (POPC) lipid bilayer, solvated in water, then minimized and equilibrated by means of molecular dynamics simulations.	Water	160-165	aquaporin 4	Homo sapiens	19-23
21856282-8	2011	By using Brownian dynamics fluctuation-dissipation-theorem (BD-FDT), the overall free-energy profile was obtained for water transporting through AQP4 for the first time, which gives a complete map of the entire channel of water permeation.	Water	118-123	aquaporin 4	Homo sapiens	145-149
21856282-8	2011	By using Brownian dynamics fluctuation-dissipation-theorem (BD-FDT), the overall free-energy profile was obtained for water transporting through AQP4 for the first time, which gives a complete map of the entire channel of water permeation.	Water	222-227	aquaporin 4	Homo sapiens	145-149
21836325-4	2011	Compared with P-25, the nanotubes showed higher photocatalytic degradation of rhodamine B and water splitting efficiency.	Water	94-99	tubulin polymerization promoting protein	Homo sapiens	14-18
21957902-2	2012	Additionally, Kv7.1 is expressed in epithelial tissues playing a role in salt and water transport.	Water	82-87	potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog	Xenopus laevis	14-19
21967193-6	2012	RESULTS: All samples sank in tap water but floated in a saturated salt solution, consistent with naphthalene.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
23109569-6	2012	Average removal rates of water quality parameters by the DAF-MBR system were very high, e.g. COD(cr) 95.88%, BOD5 99.66%, COD(mn) (chemical oxygen demand by Mn) 93.63%, T-N 69.75%, NH4-N 98.46%, T-P 78.23%, and SS 99.51%, which satisfy effluent water quality standards.	Water	25-30	translocator protein	Homo sapiens	61-64
23109569-6	2012	Average removal rates of water quality parameters by the DAF-MBR system were very high, e.g. COD(cr) 95.88%, BOD5 99.66%, COD(mn) (chemical oxygen demand by Mn) 93.63%, T-N 69.75%, NH4-N 98.46%, T-P 78.23%, and SS 99.51%, which satisfy effluent water quality standards.	Water	245-250	translocator protein	Homo sapiens	61-64
3182767-0	1988	The sites on calmodulin cross-linked to myosin light chain kinase and troponin I with water-soluble carbodiimide.	Water	86-91	CaM5	Triticum aestivum	13-23
22377992-3	2012	The research work was performed using a laboratory-scale pilot plant that was filled with tap water.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
21728895-15	2011	Scenario analyses with a higher consumption of vegetables or a higher nitrate concentration in tap water showed a significant higher intake of nitrate.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
22204662-1	2011	BACKGROUND: Serum autoantibodies against the water channel aquaporin-4 (AQP4) are important diagnostic biomarkers and pathogenic factors for neuromyelitis optica (NMO).	Water	45-50	aquaporin 4	Homo sapiens	72-76
11538473-1	1988	Theoretical potentials for rotational excitation of H2O by He were constructed via several methods, all of which start with a large basis set SCF interaction.	Water	52-55	KIT ligand	Homo sapiens	142-145
22087205-5	2011	NMO-IgG is an autoantibody that targets aquaporin-4 (AQP4), the most abundant water channel in the CNS; hence, it was named anti-AQP4 antibody.	Water	78-83	aquaporin 4	Homo sapiens	40-51
22087205-5	2011	NMO-IgG is an autoantibody that targets aquaporin-4 (AQP4), the most abundant water channel in the CNS; hence, it was named anti-AQP4 antibody.	Water	78-83	aquaporin 4	Homo sapiens	53-57
22087205-5	2011	NMO-IgG is an autoantibody that targets aquaporin-4 (AQP4), the most abundant water channel in the CNS; hence, it was named anti-AQP4 antibody.	Water	78-83	aquaporin 4	Homo sapiens	129-133
21584291-0	2011	Spin-crossover in [Fe(3-bpp)2][BF4]2 in different solvents--a dramatic stabilisation of the low-spin state in water.	Water	110-115	spindlin 1	Homo sapiens	0-4
21584291-0	2011	Spin-crossover in [Fe(3-bpp)2][BF4]2 in different solvents--a dramatic stabilisation of the low-spin state in water.	Water	110-115	spindlin 1	Homo sapiens	96-100
21872326-2	2011	Temperature-controlled water vapor annealing was used to control beta-sheet crystal formation to generate insoluble silk-tropoelastin biomaterial matrices at defined ratios of the two proteins.	Water	23-28	elastin	Homo sapiens	121-133
21736779-2	2011	The present study investigated the inhibitory effect of an ethanol-water extract from bamboo (BEX, Phyllostachys edulis) on the blood concentration of MCP-1.	Water	67-72	chemokine (C-C motif) ligand 2	Mus musculus	151-156
22189330-5	2011	We suggest the following indications for PEG: 1.Difficulty in ingestion of sufficient quantities of food and water because of pain on swallowing, or an obstruction caused by cancer.	Water	109-114	mesoderm specific transcript	Homo sapiens	41-47
22457989-8	2011	The Tlemcen tap water contains acceptable fluorine content, but the mineral water, with an excessive contribution, can cause fluorose.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
22304190-3	2011	In this study, the interaction between two oscillating differently sized bubbles (generated in tap water) is studied using high speed photography.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
21964555-0	2011	Study of the ST2 model of water close to the liquid-liquid critical point.	Water	26-31	ST2	Homo sapiens	13-16
21964555-1	2011	We perform successive umbrella sampling grand canonical Monte Carlo computer simulations of the original ST2 model of water in the vicinity of the proposed liquid-liquid critical point, at temperatures above and below the critical temperature.	Water	118-123	ST2	Homo sapiens	105-108
21970362-2	2011	Recently, we presented a molecular dynamics (MD) study on blood coagulation factor Xa (fXa) to investigate the effect of water molecules on the flexibility of the protein structure.	Water	121-126	coagulation factor X	Homo sapiens	76-85
21970362-2	2011	Recently, we presented a molecular dynamics (MD) study on blood coagulation factor Xa (fXa) to investigate the effect of water molecules on the flexibility of the protein structure.	Water	121-126	coagulation factor X	Homo sapiens	87-90
21989727-7	2011	RESULTS: IRBPp-specific CD25+CD4+ T cells from spleens of EAU-recovered wild-type mice express a Treg cell phenotype of FoxP3 and TGF-beta compared with the effector T-cell phenotype of IFN-gamma and IL-17 production in EAU-recovered MC5r-/- mice.	Water	58-61	interleukin 2 receptor, alpha chain	Mus musculus	24-28
21989727-7	2011	RESULTS: IRBPp-specific CD25+CD4+ T cells from spleens of EAU-recovered wild-type mice express a Treg cell phenotype of FoxP3 and TGF-beta compared with the effector T-cell phenotype of IFN-gamma and IL-17 production in EAU-recovered MC5r-/- mice.	Water	58-61	interleukin 17A	Mus musculus	200-205
21989727-7	2011	RESULTS: IRBPp-specific CD25+CD4+ T cells from spleens of EAU-recovered wild-type mice express a Treg cell phenotype of FoxP3 and TGF-beta compared with the effector T-cell phenotype of IFN-gamma and IL-17 production in EAU-recovered MC5r-/- mice.	Water	220-223	interleukin 2 receptor, alpha chain	Mus musculus	24-28
21967647-3	2011	Due to the formation of a Meisenheimer complex between DNAN and the modifier, the modified AgNPs can detect 20 mug/L (0.2 ng) and 0.1 mg/L (1 ng) DNAN in deionized water and aged tap water, respectively.	Water	183-188	nuclear RNA export factor 1	Homo sapiens	179-182
22088052-5	2011	Demonstrations on simple systems are provided, including an assessment of the thermal properties of the neutral water dimer with B3LYP/6-31++G**.	Water	112-117	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	131-134
21832207-11	2011	These observations suggest the existence of multiple mechanisms of Na(+) uptake in larval zebrafish in acidic water: one in which Na(+) uptake via NHE3b is linked to ammonia excretion via Rhcg1, and another facilitated by H(+)-ATPase.	Water	110-115	solute carrier family 9 member A3, tandem duplicate 2	Danio rerio	147-152
21920744-2	2011	Starting with a low nanomolar benzofuranopyrimidine HTS hit devoid of pharmaceutically acceptable properties, we navigated issues with metabolism and solubility to furnish a potent, stable and water soluble tricyclic histamine H(4) receptor antagonist with desirable physiochemical parameters which demonstrated efficacy a mouse ova model.	Water	193-198	histamine receptor H4	Mus musculus	217-240
21756932-2	2011	We investigate the anti-ischemic properties of a water-soluble beta-D-fructan (MDG-1) from O. japonicus, and assess the antidiabetic effects of MDG-1.	Water	49-54	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	79-84
21688051-1	2011	The microstructure of water soluble nanoaggregates based on polyelectrolyte complex formed by the cationic comb-type copolymer poly(acrylamide -co-[3- (methacryloyl-amino)propyl] trimethylammonium chloride)-graft- polyacrylamide [P(AM-co-MAPTAC)-g-PAM] and the anionic linear polyelectrolyte sodium polyacrylate (NaPA) was investigated using the fluorescence probe technique.	Water	22-27	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	248-251
22011386-10	2011	This change in AQP4 expression appears to act as an important determinant in the exacerbation of edema, considering that AQP4 expression is insufficient to counter the water influx during the build-up phase, while the second more pronounced but delayed upregulation is involved in the resolution phase.	Water	168-173	aquaporin 4	Homo sapiens	15-19
21879743-7	2011	The results of this study confirm that sucralose will function well as an indicator compound for anthropogenic influence on source, finished drinking and distribution system (i.e., tap) water, as well as an indicator compound for the presence of other recalcitrant compounds in finished drinking water in the U.S.	Water	186-191	nuclear RNA export factor 1	Homo sapiens	181-184
21877721-8	2011	Finally, our work shows that the natural base adenine (A) is further inserted into the AAG active site than the damaged substrates, which results in the loss of a hydrogen bond with Y127 and misaligns the general base (E125) and water nucleophile to lead to poor nucleophile activation.	Water	229-234	N-methylpurine DNA glycosylase	Homo sapiens	87-90
22108422-1	2011	OBJECTIVE: This paper aims to investigate the impact of anthracene addition on microbial community in agricultural soil irrigated with tap water or reclaimed wastewater.	Water	139-144	nuclear RNA export factor 1	Homo sapiens	135-138
22251740-6	2011	Light microscopy of B. pseudofea larvae revealed small air pockets in and around the spiracles when submerged in tap water; these air pockets  disappeared when exposed to detergent solution.	Water	117-122	nuclear RNA export factor 1	Homo sapiens	113-116
21796783-7	2011	A series of tap water samples were subjected to analysis, fortunately giving negative results.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
21443496-1	2011	In the biomimetic design two hydrophobic pentapetides Boc-Ile-Aib-Leu-Phe-Ala-OMe (I) and Boc-Gly-Ile-Aib-Leu-Phe-OMe (II) (Aib: alpha-aminoisobutyric acid) containing one Aib each are found to undergo solvent assisted self-assembly in methanol/water to form vesicular structures, which can be disrupted by simple addition of acid.	Water	245-250	ANIB1	Homo sapiens	102-105
21443496-1	2011	In the biomimetic design two hydrophobic pentapetides Boc-Ile-Aib-Leu-Phe-Ala-OMe (I) and Boc-Gly-Ile-Aib-Leu-Phe-OMe (II) (Aib: alpha-aminoisobutyric acid) containing one Aib each are found to undergo solvent assisted self-assembly in methanol/water to form vesicular structures, which can be disrupted by simple addition of acid.	Water	245-250	ANIB1	Homo sapiens	102-105
21443496-1	2011	In the biomimetic design two hydrophobic pentapetides Boc-Ile-Aib-Leu-Phe-Ala-OMe (I) and Boc-Gly-Ile-Aib-Leu-Phe-OMe (II) (Aib: alpha-aminoisobutyric acid) containing one Aib each are found to undergo solvent assisted self-assembly in methanol/water to form vesicular structures, which can be disrupted by simple addition of acid.	Water	245-250	ANIB1	Homo sapiens	102-105
21788486-6	2011	Our structural data indicate that the water-exposed CD1e groove could ensure the establishment of loose contacts with lipids.	Water	38-43	CD1e molecule	Homo sapiens	52-56
21748816-6	2011	The simultaneous and selective elimination of target toxicants is successfully performed for tap-water samples containing toxicant mixtures.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
21749063-5	2011	With a view on first-principle insight into the in situ STM behavior of robust redox (as opposed to nonredox) molecules, we present in this report a density functional theory (DFT) study of the complexes in both free and adsorbate state, in either state exposed to both stoichiometric counterions and a large assembly of solvent water molecules.	Water	329-334	sulfotransferase family 1A member 3	Homo sapiens	56-59
22090875-2	2011	The Ca(II) atom is octa-coordinated by two O atoms from two water mol-ecules and six O atoms from four acetate ligands.	Water	60-65	carbonic anhydrase 2	Homo sapiens	4-10
21543416-2	2011	Kir4.1, the inwardly rectifying potassium channel, and aquaporin-4 (AQP4), the type 4 water-permeable channel, are localized at the basolateral domain of polarized epithelial cells; however, the mechanisms involved in their localization have yet to be determined.	Water	86-91	aquaporin 4	Canis lupus familiaris	55-66
21543416-2	2011	Kir4.1, the inwardly rectifying potassium channel, and aquaporin-4 (AQP4), the type 4 water-permeable channel, are localized at the basolateral domain of polarized epithelial cells; however, the mechanisms involved in their localization have yet to be determined.	Water	86-91	aquaporin 4	Canis lupus familiaris	68-72
21766475-8	2011	The applicability of the SPE-FASI-CZE method was evaluated by analyzing drinking tap water from Barcelona where seven HAAs were found at concentration levels between 3 and 13 mug/L.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
21301855-4	2011	METHODS: Based on a large Japanese observational cohort, we have used weighted regression analysis to identify putative effects of tap water-derived lithium uptake on overall mortality.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	131-134
22303580-0	2011	Major inorganic elements in tap water samples in Peninsular Malaysia.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
22303580-6	2011	Iron concentration of tap water from one of the locations was higher than the standard limit.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
22303580-7	2011	CONCLUSION: In general, tap water from different parts of Peninsular Malaysia had low concentrations of heavy metals and inorganic elements.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
21918642-2	2011	We analysed the interaction between human population density and lack of tap water as a cause of dengue fever outbreaks with the aim of identifying geographic areas at highest risk.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
22112398-2	2011	In this study, we used ArsC as an N-terminal fusion partner to synthesize nine aggregation-prone proteins as water-soluble forms.	Water	109-114	Arsenate reductase	Escherichia coli	23-27
21631122-5	2011	Scanning electron microscopy and fluorescence microscopy studies indicated that flocs of the PDEA-PS particles were adsorbed at the surface of these water droplets, leading to stable liquid marbles.	Water	149-154	phosphodiesterase 6A	Homo sapiens	93-97
22229131-0	2011	Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model.	Water	35-40	poly (ADP-ribose) polymerase family, member 1	Mus musculus	49-53
21712603-6	2011	The production of hydrogen gas from POME during EC was also compared with hydrogen gas production by electrolysis of tap water at pH 4 and tap water without pH adjustment under the same conditions.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
21712603-6	2011	The production of hydrogen gas from POME during EC was also compared with hydrogen gas production by electrolysis of tap water at pH 4 and tap water without pH adjustment under the same conditions.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
21459832-5	2011	The HvDhn4s:TaNAC69 transgenic lines produced more shoot biomass under combined mild salt stress and water-limitation conditions, had longer root and more root biomass under polyethylene glycol-induced dehydration.	Water	101-106	NAC transcription factor 29	Triticum aestivum	12-19
21691149-0	2011	Regulation of stomatal density by the GTL1 transcription factor for improving water use efficiency.	Water	78-83	GT-2-like 1	Arabidopsis thaliana	38-42
21691149-5	2011	GTL1 directly interacts with the SDD1 promoter regulating stomatal density, transpiration, and water use efficiency (WUE).	Water	95-100	GT-2-like 1	Arabidopsis thaliana	0-4
21691149-5	2011	GTL1 directly interacts with the SDD1 promoter regulating stomatal density, transpiration, and water use efficiency (WUE).	Water	95-100	Subtilase family protein	Arabidopsis thaliana	33-37
21504173-3	2011	The data reflects a well-defined surface structure that maintains proton order even at surprisingly high temperatures of 140 K. The diffraction data we measure is consistent with a structure recently derived from STM measurements performed at 6 K. Comparison with recent DFT calculation is in partial agreement, suggesting that these calculations might be underestimating the contribution of relative water molecule orientations to the binding energy.	Water	401-406	sulfotransferase family 1A member 3	Homo sapiens	213-216
21689527-1	2011	Tetramers of aquaporin-4 (AQP4) water channels form supramolecular assemblies in cell membranes called orthogonal arrays of particles (OAPs).	Water	32-37	aquaporin 4	Homo sapiens	13-24
21689527-1	2011	Tetramers of aquaporin-4 (AQP4) water channels form supramolecular assemblies in cell membranes called orthogonal arrays of particles (OAPs).	Water	32-37	aquaporin 4	Homo sapiens	26-30
21529816-1	2011	This paper reports unusual on-column degradations of aniline compounds on Waters XBridge Shield RP18 column when ammonium hydroxide in water and acetonitrile were used as mobile phases in liquid chromatography.	Water	135-140	pre-mRNA processing factor 3	Homo sapiens	96-100
21784314-10	2011	CONCLUSION: The outbreak reported here was caused by drinking tap water contaminated with sewage at the source.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
21300396-0	2011	Leaching of Cu and Zn from discarded boat paint particles into tap water and rain water.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
21300396-2	2011	Leaching rates appeared to be diffusion-controlled and were greater in rain water than in tap water and were greater for Zn than for Cu.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
21429555-5	2011	In comparison to organisms cultured for the same period of time in artificial sea water prepared by filtered tap water, the expression of the alkaline isoenzyme decreased by 62% while that of the neutral isoenzyme increased by 58%.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	109-112
21451419-7	2011	The sEH inhibitor 12-(3-adamantan-1-yl-ureido)dodecanoic acid administered for 2 weeks starting 5 weeks after surgery in 2K1C mice (25 mg/l in drinking water) reduced aortic pressures and cardiac hypertrophy, improved the coronary relaxations to acetylcholine and restored the inhibitory effect of fluconazole and MSPPOH on acetylcholine-induced relaxations, without modifying the relaxations to NS309 and NS1619.	Water	152-157	epoxide hydrolase 2, cytoplasmic	Mus musculus	4-7
21754317-1	2011	In title compound, [Ca(C(7)H(5)O(2))(2)(C(7)H(6)O(2))(H(2)O)](n), the eightfold-coordinated Ca(II) ion is bonded to four carboxyl-ate O atoms from two benzoate ions, an O atom from benzoic acid and a water O atom.	Water	54-60	carbonic anhydrase 2	Homo sapiens	92-98
21754317-1	2011	In title compound, [Ca(C(7)H(5)O(2))(2)(C(7)H(6)O(2))(H(2)O)](n), the eightfold-coordinated Ca(II) ion is bonded to four carboxyl-ate O atoms from two benzoate ions, an O atom from benzoic acid and a water O atom.	Water	200-205	carbonic anhydrase 2	Homo sapiens	92-98
21354650-3	2011	Aquaporin 4 (AQP4), the major water channel in astrocytes, has been shown to be important in astrocyte migration.	Water	30-35	aquaporin 4	Homo sapiens	0-11
21354650-3	2011	Aquaporin 4 (AQP4), the major water channel in astrocytes, has been shown to be important in astrocyte migration.	Water	30-35	aquaporin 4	Homo sapiens	13-17
2968279-3	1988	These findings indicate that ANP may have a role in the physiology of the gastrointestinal tract, e.g. in the regulation of water and electrolyte absorption.	Water	124-129	natriuretic peptide A	Rattus norvegicus	29-32
3131879-4	1988	Moreover, 24-hour water deprivation resulted in Fos expression in paraventricular and supraoptic nuclei.	Water	18-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-51
2837229-14	1988	Reaction of BP and 6-FBP radical cation perchlorates with water produced the same BP quinones.	Water	58-63	far upstream element binding protein 1	Rattus norvegicus	21-24
21899930-8	2011	Possible binding modes of these structures within the MAO-B active site are proposed with the emphasis on the interactions of the inhibitor halogens and the hydroxyl and nitrile functional groups with active site residues and water molecules.	Water	226-231	monoamine oxidase B	Homo sapiens	54-59
3275305-1	1988	The influence of water activity on the production of B1, B2, G1 and G2 aflatoxins in corn has been examined.	Water	17-22	anthocyanin regulatory R-S protein-like	Zea mays	53-70
22586241-6	2011	In this study, dilution of the tap water sample by adding 4% MeOH (v/v) was observed to be adequate to compensate for the signal suppression.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
22200008-10	2011	CONCLUSION: Early up-regulation of MMP-9 might be correlated with increased water content in the spinal cord at 24 h after SCI in rats.	Water	76-81	matrix metallopeptidase 9	Rattus norvegicus	35-40
2970865-1	1988	Fourier transform infrared spectroscopy was used to investigate the secondary structure of human complement component factor H in H2O and 2H2O buffers.	Water	130-133	complement factor H	Homo sapiens	118-126
20390281-3	2011	This study was conducted to assess the efficacy of mud-bath therapy with mineral water from the Sillene Spring at Italy"s Chianciano Spa in patients with osteoarthritis of the knee.	Water	81-86	surfactant protein A2	Homo sapiens	133-136
3389861-6	1988	We conclude that the airways were protected against the bronchoconstricting effect of nebulised water by the beta 2 adrenoreceptor stimulant salbutamol.	Water	96-101	adrenoceptor beta 2	Homo sapiens	109-130
21872294-0	2011	Hypertension incidence after tap-water implementation: a 13-year follow-up study in the arseniasis-endemic area of southwestern Taiwan.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
2837529-1	1988	Four new water soluble complexes of the formula [Pt(DA)(DDTC)]NO3 (where DA is 2,2"-bipyridine, 1,10-phenanthroline, 1,2-diaminopropane, or 1,2-diaminocyclohexane, and DDTC is diethyldithiocarbamate anion) have been synthesized by reaction of platinum-diamine/diimine diaqua complex with sodium diethyldithiocarbamate in molar ratio of 1:1.	Water	9-14	NBL1, DAN family BMP antagonist	Mus musculus	62-65
22242435-0	2011	[Effect of water extract from traditional Chinese medicines Rehmannia glutinosa, Scrophularia ningpoensis, Asparagus cochinchinensis and Ophiopogon japonicas on contents of CYP450 and activities of CYP3A, CYP2E1 and CYP1A2 in rat].	Water	11-16	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	216-222
22242435-1	2011	OBJECTIVE: To study the effects of the water extract of Rehmannia glutionsa, Scrophularia ningpoensis, Asparagus cochinchinensis and Ophiopogon japonicas, which are the drug from Tianwang Buxin Wan from nourishing vin, on the content of cytohrome P450 (CYP450) in rat and the activities of CYP3A, CYP2E1 and CYP1A2 to investigate the role of CYP450 in the biotransformation of Tianwang Buxin Wan.	Water	39-44	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	308-314
22242435-4	2011	The water extract of R. glutionsa obviously decreased the contents of P450 (P &lt; 0.01) and increased the activity of CYP3A (P &lt; 0.01) and CYP1A2 (P &lt;0.05).	Water	4-9	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	143-149
22242435-5	2011	The water extract of S. ningpoensis decreased the contents of P450 (P &lt; 0.05) and significantly increased CYP3A and CYP1A2 activities (P &lt; 0.01).	Water	4-9	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	119-125
3348805-0	1988	Inactivation of bovine thrombin by water-soluble carbodiimides: the essential carboxyl group has a pKa of 5.51.	Water	35-40	coagulation factor II, thrombin	Bos taurus	23-31
21818500-0	2011	A water soluble vitamin B12-ReI fluorescent conjugate for cell uptake screens: use in the confirmation of cubilin in the lung cancer line A549.	Water	2-7	cubilin	Homo sapiens	106-113
21818500-1	2011	A water soluble vitamin B(12)-rhenium conjugate was synthesized and used in concert with intrinsic factor to screen for cubilin receptor-mediated uptake in lung cancer cells.	Water	2-7	cubilin	Homo sapiens	120-127
3137946-3	1988	The present immunohistochemical study demonstrates the depletion of GRP immunoreactivity from nerves in the oxyntic mucosa of rats with ulcers induced by restraint plus water immersion.	Water	169-174	gastrin releasing peptide	Rattus norvegicus	68-71
21633078-1	2011	Aquaporin-5 (AQP5), a water channel, plays key roles in salivary secretion.	Water	22-27	aquaporin 5	Mus musculus	0-11
21633078-1	2011	Aquaporin-5 (AQP5), a water channel, plays key roles in salivary secretion.	Water	22-27	aquaporin 5	Mus musculus	13-17
2964203-14	1988	This altered responsiveness to ANF may contribute to the sodium and water retention characteristic of this disorder.	Water	68-73	natriuretic peptide A	Rattus norvegicus	31-34
21565469-4	2011	Transferrin was coupled to get SLE-6 by water soluble EDC method and purified by gel filtration.	Water	40-45	transferrin	Mus musculus	0-11
3278629-2	1988	Water deprivation produced marked increases in plasma renin activity and the concentration of AVP; however, plasma catecholamine concentrations were unchanged.	Water	0-5	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	94-97
21565469-4	2011	Transferrin was coupled to get SLE-6 by water soluble EDC method and purified by gel filtration.	Water	40-45	systemic lupus erythematosus susceptibility 6	Mus musculus	31-36
21643837-3	2011	The survey assessed current behaviors as well as perceived barriers and benefits to drinking tap water versus bottled water.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
21643837-8	2011	Important barriers to drinking tap water at Purdue include: perceived risks from tap water and the perceived safety of bottled water, preferring the taste of bottled water, and the convenience of drinking bottled water.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
21643837-8	2011	Important barriers to drinking tap water at Purdue include: perceived risks from tap water and the perceived safety of bottled water, preferring the taste of bottled water, and the convenience of drinking bottled water.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	81-84
3278629-11	1988	However, activation of sympathetic nerve activity may become important in maintaining peripheral resistance when ANG II and AVP receptors are blocked in water-deprived animals.	Water	153-158	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	124-127
2853669-3	1988	The presence of water led to the maintenance of the 2"-GMP-RNase T1 interactions as compared to the X-ray structure, including the hydrogen bonds implicated in the enzyme-inhibitor recognition process.	Water	16-21	5'-nucleotidase, cytosolic II	Homo sapiens	55-58
21643837-8	2011	Important barriers to drinking tap water at Purdue include: perceived risks from tap water and the perceived safety of bottled water, preferring the taste of bottled water, and the convenience of drinking bottled water.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	31-34
21643837-8	2011	Important barriers to drinking tap water at Purdue include: perceived risks from tap water and the perceived safety of bottled water, preferring the taste of bottled water, and the convenience of drinking bottled water.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	31-34
21643837-8	2011	Important barriers to drinking tap water at Purdue include: perceived risks from tap water and the perceived safety of bottled water, preferring the taste of bottled water, and the convenience of drinking bottled water.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	31-34
21643837-8	2011	Important barriers to drinking tap water at Purdue include: perceived risks from tap water and the perceived safety of bottled water, preferring the taste of bottled water, and the convenience of drinking bottled water.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	31-34
3373763-0	1988	[Effect of GRP on gastric blood flow and tissue GRP in water immersed stress rats].	Water	55-60	gastrin releasing peptide	Rattus norvegicus	48-51
21643837-9	2011	The qualitative interviews revealed that drinking water choices can be influenced by several factors-especially whether individuals trust tap water to be clean-but involve varying levels of complexity.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	138-141
21643837-10	2011	The implications of these results for social marketing strategies to promote tap water are discussed.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
3151020-15	1988	The SCN- molecule reaches into the deep end of the active site cavity where the sulfur atom has displaced the so-called "deep" water molecule of the native enzyme.	Water	127-132	sorcin	Homo sapiens	4-7
21976197-3	2011	Water samples were processed in such a way as to simulate real life conditions for drinking filtered water or hot water drinks prepared from tap water drawn from public water supply systems.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	141-144
21976197-7	2011	CONCLUSION: This study suggests that different methods of processing tap water can change DBP concentration to an extent that would have a meaningful impact on exposure assessment in epidemiological studies.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
21766860-8	2011	The dynamics of water observed during the simulations provides an explanation for the conformational changes observed in the solution-based fluorescence spectroscopic measurements on agonist activated beta2AR, which could not be explained by the agonist bound beta2AR crystal structure.	Water	16-21	adrenoceptor beta 2	Homo sapiens	201-208
21766860-8	2011	The dynamics of water observed during the simulations provides an explanation for the conformational changes observed in the solution-based fluorescence spectroscopic measurements on agonist activated beta2AR, which could not be explained by the agonist bound beta2AR crystal structure.	Water	16-21	adrenoceptor beta 2	Homo sapiens	260-267
21500305-1	2011	The gas-phase ion chemistry of GeF(4) and of its mixtures with water, ammonia and hydrocarbons was investigated by ion trap mass spectrometry (ITMS) and ab initio calculations.	Water	63-68	Rho guanine nucleotide exchange factor 4	Homo sapiens	31-37
3151020-16	1988	The zinc-bound water molecule is 2.2 A from the zinc ion and 2.4 A from the SCN- nitrogen.	Water	15-20	sorcin	Homo sapiens	76-79
2965426-1	1988	Atrial natriuretic peptide is a peptide regulating salt and water balance, originally isolated from the cardiac atrium, where it is synthesised as part of a precursor molecule in specialised myocardial cells.	Water	60-65	natriuretic peptide A	Rattus norvegicus	0-26
21389011-6	2011	Individual exposure to THMs was calculated combining information on residential history, estimates of the average total THMs (TTHM) level in tap water at the successive residences and personal water consumption.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
21750807-2	2011	In the gas phase, H(3)O is a radical with spin density localized on its hydrogen end, which is only kinetically stable and readily decomposes into a water molecule and a hydrogen atom.	Water	149-154	H3 clustered histone 15	Homo sapiens	18-23
21750807-3	2011	When solvated by a single water molecule, H(3)O preserves to a large extent its radical character, however, two water molecules are already capable to shift most of the spin density to the solvent.	Water	26-31	H3 clustered histone 15	Homo sapiens	42-47
21750807-3	2011	When solvated by a single water molecule, H(3)O preserves to a large extent its radical character, however, two water molecules are already capable to shift most of the spin density to the solvent.	Water	112-117	H3 clustered histone 15	Homo sapiens	42-47
21525279-1	2011	Aquaporin-4 (AQP4) is the major water channel in the CNS and is primarily expressed in astrocytes.	Water	32-37	aquaporin 4	Mus musculus	0-11
2961879-5	1987	ANP treatment resulted in a significant peak increase in sodium (5.6-fold), lithium (2.1-fold), potassium (2.3-fold) and water (5.1-fold) excretion.	Water	121-126	natriuretic peptide A	Rattus norvegicus	0-3
21525279-1	2011	Aquaporin-4 (AQP4) is the major water channel in the CNS and is primarily expressed in astrocytes.	Water	32-37	aquaporin 4	Mus musculus	13-17
21705522-7	2011	In tap water and in water from dental chairs, antibiotic resistance was more prevalent than in the other samples, mainly due to the predominance of isolates of the genera Sphingomonas and Sphingobium.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
2888608-0	1987	Effect of somatostatin analog on water and electrolyte transport and transit time in human small bowel.	Water	33-38	somatostatin	Homo sapiens	10-22
22128736-6	2011	The developed method was successfully applied for the analysis of tap water, bottle drinking water and lake water, and none of the 13 PAEs was detected.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
21296884-7	2011	We also demonstrated that hydrophobic domain 1 and the loop domain of Pen-2 are located in a water-containing cavity and are in short proximity to the presenilin C-terminal fragment.	Water	93-98	presenilin enhancer, gamma-secretase subunit	Homo sapiens	70-75
21453950-5	2011	Ozonation of aerobically treated grey water at an applied ozone dose of 15 mgL(-1), reduced the concentrations of octocrylene, nonylphenol, triclosan, galaxolide, tonalide and 4-methylbenzylidene-camphor to below limits of quantification, with removal efficiencies of at least 79%.	Water	38-43	LLGL scribble cell polarity complex component 1	Homo sapiens	75-81
21707036-4	2011	This result indicates that the hydrophilic core group is anchored to ions in the water via bidentate chelates with the carboxylate oxygen atoms of G1 and G2.	Water	81-86	proline rich protein BstNI subfamily 3	Homo sapiens	147-156
2888608-1	1987	The present study was undertaken to investigate how a somatostatin analog (201-995 Sandoz), which is now commonly used for treatment of patients with gut hormone-producing tumors, affects water and ion absorption and transit time in the normal jejunum.	Water	188-193	somatostatin	Homo sapiens	54-66
21255559-12	2011	CONCLUSION: The results provided new information that antenatal water deprivation induces a reprogramming of brain RAS and Ang II receptor expression patterns and alters the central Ang II-mediated dipsogenic response in offspring in a sex-dependent manner.	Water	64-69	angiogenin	Rattus norvegicus	123-126
2956192-4	1987	Volume contraction induced by furosemide treatment of chronic water restriction significantly reduced the circulating immunoreactive ANF.	Water	62-67	natriuretic peptide A	Rattus norvegicus	133-136
21255559-12	2011	CONCLUSION: The results provided new information that antenatal water deprivation induces a reprogramming of brain RAS and Ang II receptor expression patterns and alters the central Ang II-mediated dipsogenic response in offspring in a sex-dependent manner.	Water	64-69	angiogenin	Rattus norvegicus	182-185
21671682-4	2011	In addition, SF1 and SF2 can be used to detect H(2)S in both water and live cells, providing a potentially powerful approach for probing H(2)S chemistry in biological systems.	Water	61-66	splicing factor 1	Homo sapiens	13-16
3301614-4	1987	The tap-water enema group was, therefore, suspended but the rest of the study continued after rerandomization for lactose and lactitol groups.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
21671682-4	2011	In addition, SF1 and SF2 can be used to detect H(2)S in both water and live cells, providing a potentially powerful approach for probing H(2)S chemistry in biological systems.	Water	61-66	serine and arginine rich splicing factor 1	Homo sapiens	21-24
21252231-0	2011	Expression of water-soluble, ligand-binding concatameric extracellular domains of the human neuronal nicotinic receptor alpha4 and beta2 subunits in the yeast Pichia pastoris: glycosylation is not required for ligand binding.	Water	14-19	immunoglobulin binding protein 1	Homo sapiens	120-126
21252231-6	2011	We then linked the mutated ECDs with the 24-amino acid peptide (AGS)(8) and observed that the beta2-24-alpha4 ECD concatamer, but not the alpha4-24-beta2 one, exhibited very satisfactory water solubility and ligand binding properties.	Water	187-192	immunoglobulin binding protein 1	Homo sapiens	103-109
21429969-6	2011	In addition, NR3a knockdown cells exhibited reduced water transport in response to the addition of vasopressin, suggesting an alteration in aquaporin-2 (AQP2) expression/function.	Water	52-57	glutamate receptor ionotropic, NMDA3A	Mus musculus	13-17
3301614-8	1987	These data suggest that acidifying agents like lactose and lactitol are effective and superior to tap-water enemas for the treatment of acute nitrogenous portal-systemic encephalopathy.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
21429969-10	2011	Finally, NR3a(-/-) mice showed a significant delay in their ability to increase urine osmolality during water restriction.	Water	104-109	glutamate receptor ionotropic, NMDA3A	Mus musculus	9-13
21429969-12	2011	Therefore, under conditions that are associated with high vasopressin levels, NR3a, by maintaining low intracellular calcium levels, protects the function of the principal cells to reabsorb water and thereby increase medullary osmolality.	Water	190-195	glutamate receptor ionotropic, NMDA3A	Mus musculus	78-82
3472669-1	1987	Tap water use.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
20843387-1	2011	An inappropriate cross-connection between sewage- and drinking-water pipelines contaminated tap water in a Finnish town, resulting in an extensive waterborne gastroenteritis outbreak in this developed country.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	92-95
20697416-3	2011	RESULTS: Treatment of these animals for 15 days with ZAG (100  mug, intravenously, daily) resulted in a reduction of body weight of 6.55  g compared with phosphate-buffered saline-treated controls, without a change in food or water intake, but with a 0.4  C rise in rectal temperature.	Water	226-231	alpha-2-glycoprotein 1, zinc	Mus musculus	53-56
20877385-0	2011	Brain water mobility decreases after astrocytic aquaporin-4 inhibition using RNA interference.	Water	6-11	aquaporin 4	Homo sapiens	48-59
20843387-1	2011	An inappropriate cross-connection between sewage- and drinking-water pipelines contaminated tap water in a Finnish town, resulting in an extensive waterborne gastroenteritis outbreak in this developed country.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
20877385-6	2011	Because of this critical role and the recognition that brain AQP4 is distributed within astrocytic cell membranes, we hypothesized that AQP4 contributes to the regulation of water diffusion and variations in its expression would alter ADC values in normal brain.	Water	174-179	aquaporin 4	Homo sapiens	136-140
3582700-1	1987	In anesthetized dogs with cannulae implanted in the lateral cerebral ventricle, the water transfer from the CSF to the blood was studied using determination of drainage of tritiated water injected into the ventricle.	Water	84-89	colony stimulating factor 2	Canis lupus familiaris	108-111
21465540-7	2011	However, nonurban deep-water sediment PBDE profiles were both heavier and had higher concentration-weighted average log K(OW) (octanol-water partition coefficient) values compared to shallow samples (percent BDE-209 of total PBDE, 66 versus 32%; log K(OW) , 9.5 versus 8.2, respectively).	Water	23-28	homeobox D13	Homo sapiens	39-42
2969452-4	1987	Cardiac ANP mRNA in dehydrated animals fell to 25% of that in the water-replete controls.	Water	66-71	natriuretic peptide A	Rattus norvegicus	8-11
21377446-3	2011	First, we analyzed the surface activity of P59 at the air-water interface as well as its interaction with zwitterionic or negatively charged lipid monolayers.	Water	58-63	HLA complex P5B	Homo sapiens	43-46
3814176-7	1987	When [18O]H2O was included in incubations of microsomes and CS2, a substantial portion of the resulting COS was [18O] enriched, indicating that the oxygen atom was derived from water.	Water	10-13	calsyntenin 2	Rattus norvegicus	60-63
21998601-3	2011	This study was undertaken to test the hypothesis that cyclophosphamide may produce water retention via the proximal nephron, where aquaporin-1 (AQP1) and aquaporin-7 (AQP7) water channels participate in water absorption.	Water	83-88	aquaporin 7	Rattus norvegicus	154-165
21998601-3	2011	This study was undertaken to test the hypothesis that cyclophosphamide may produce water retention via the proximal nephron, where aquaporin-1 (AQP1) and aquaporin-7 (AQP7) water channels participate in water absorption.	Water	83-88	aquaporin 7	Rattus norvegicus	167-171
21998601-3	2011	This study was undertaken to test the hypothesis that cyclophosphamide may produce water retention via the proximal nephron, where aquaporin-1 (AQP1) and aquaporin-7 (AQP7) water channels participate in water absorption.	Water	173-178	aquaporin 7	Rattus norvegicus	154-165
21998601-3	2011	This study was undertaken to test the hypothesis that cyclophosphamide may produce water retention via the proximal nephron, where aquaporin-1 (AQP1) and aquaporin-7 (AQP7) water channels participate in water absorption.	Water	173-178	aquaporin 7	Rattus norvegicus	167-171
21998601-3	2011	This study was undertaken to test the hypothesis that cyclophosphamide may produce water retention via the proximal nephron, where aquaporin-1 (AQP1) and aquaporin-7 (AQP7) water channels participate in water absorption.	Water	173-178	aquaporin 7	Rattus norvegicus	154-165
21998601-3	2011	This study was undertaken to test the hypothesis that cyclophosphamide may produce water retention via the proximal nephron, where aquaporin-1 (AQP1) and aquaporin-7 (AQP7) water channels participate in water absorption.	Water	173-178	aquaporin 7	Rattus norvegicus	167-171
3814176-7	1987	When [18O]H2O was included in incubations of microsomes and CS2, a substantial portion of the resulting COS was [18O] enriched, indicating that the oxygen atom was derived from water.	Water	177-182	calsyntenin 2	Rattus norvegicus	60-63
3814176-8	1987	These data are consistent with the hypothesis that CS2 is oxidized predominantly by the cytochrome P-450 containing monooxygenase system, and the product of this reaction is an unstable intermediate which reacts with water to form monothiocarbonate and reactive sulfur species.	Water	217-222	calsyntenin 2	Rattus norvegicus	51-54
3556437-6	1987	In some cases, several zymotypes were isolated simultaneously from the same tap water.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
21998601-9	2011	From these preliminary data, we conclude that the proximal nephron may be involved in cyclophosphamide-induced water retention via AQP1 and AQP7 water channels.	Water	111-116	aquaporin 7	Rattus norvegicus	140-144
21998601-9	2011	From these preliminary data, we conclude that the proximal nephron may be involved in cyclophosphamide-induced water retention via AQP1 and AQP7 water channels.	Water	145-150	aquaporin 7	Rattus norvegicus	140-144
2431952-8	1987	Similar CCK components were found in water extracts of jejunal mucosa, whereas the acetic acid extracts mainly contained CCK-33/39.	Water	37-42	cholecystokinin	Rattus norvegicus	8-11
22417418-4	2011	Antioxidant activities of acetone, ethanol, and hot-water extracts of the flower were estimated through three biochemical models: inhibition of Cu(2+) -induced oxidation of human low-density lipoprotein, scavenging ability of oxygen radicals in human blood, and inhibition of human erythrocyte hemolysis induced by peroxyl radicals.	Water	52-57	alcohol dehydrogenase iron containing 1	Homo sapiens	48-51
3588503-6	1987	For birds raised on tap water, unilateral sodium infusion caused a significant unilateral reduction in the glomerular filtration rate.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
20952554-5	2011	Tap water samples were collected in representative mother homes on the basis of detailed water distribution patterns, and were analysed for major DBPs including trihalomethanes (THMs).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
2890285-1	1987	Alpha-linolenic acid deficiency (ALAD) is described in five adults receiving long-term gastric tube feeding with a commercially available powdered formula mixed with water and/or skimmed milk.	Water	166-171	aminolevulinate dehydratase	Homo sapiens	33-37
21440641-2	2011	AMA1-C1/ISA 720 refers to a mixture of recombinant AMA1 proteins representing the FVO and 3D7 alleles in 1:1 mass ratio, formulated with Montanide( ) ISA 720 as a water-in oil emulsion.	Water	163-168	apical membrane antigen 1	Plasmodium falciparum 3D7	0-4
3027786-4	1987	Significant additional information to the spin echo images was supplied by the fat-water images.	Water	83-88	spindlin 1	Homo sapiens	42-46
21411104-7	2011	Finally, the proposed method was applied to the analysis of water samples of different origin (tap, river and sea).	Water	60-65	nuclear RNA export factor 1	Homo sapiens	95-98
3820302-1	1986	Malate dehydrogenase from Halobacterium maris mortui exists in 4 M-NaCl as a stable protein dimer, with which are associated unusually large amounts of salt and water.	Water	161-166	malic enzyme 1	Homo sapiens	0-20
21456602-6	2011	Furthermore, in a fluoride concentration typical for tap water (10 muM), we observed roughening of individual step lines, resulting in the formation of scalloped morphologies.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
21469714-10	2011	This method could selectively detect Hg2+ and Ag+ as low as 5 nM and 10 nM in pure water with a linear range of 5 x 10-7 to 1 x 10-5 M for Hg2+ and 1 x 10-6 to 8 x 10-6 M for Ag+, respectively.	Water	83-88	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	37-40
2828375-3	1986	Following acute thermal injury to rats produced by scalding water, there was marked elevation of a number of plasma enzyme activities, including GOT, GPT, and 5"-nucleotidase, suggesting hepatic dysfunction.	Water	60-65	glutamic--pyruvic transaminase	Rattus norvegicus	150-153
21469714-10	2011	This method could selectively detect Hg2+ and Ag+ as low as 5 nM and 10 nM in pure water with a linear range of 5 x 10-7 to 1 x 10-5 M for Hg2+ and 1 x 10-6 to 8 x 10-6 M for Ag+, respectively.	Water	83-88	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	139-142
2945441-6	1986	The rapid modifications in plasma IR-ANF and AVP were accompanied by a transient but significant increase in arterial blood pressure for up to 15 min after water consumption.	Water	156-161	natriuretic peptide A	Rattus norvegicus	37-40
21376440-2	2011	The tap water reflected the contamination pattern and levels in their corresponding source water basins.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
21376440-2	2011	The tap water reflected the contamination pattern and levels in their corresponding source water basins.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	4-7
3020993-1	1986	Following intravenous infusion, angiotensin I (ANG I), angiotensin II (ANG II), and angiotensin III (ANG III) enhance Na and water absorption across the jejunum by increasing sympathetic nerve activity.	Water	125-130	angiogenin	Rattus norvegicus	47-50
21257712-9	2011	Adenovirus-mediated expression of AQP4, or of an unrelated aquaporin, AQP1, increased cytokine secretion in astrocyte and nonastrocyte cell cultures, supporting the involvement of aquaporin water permeability in cytokine secretion.	Water	190-195	aquaporin 4	Mus musculus	34-38
3020993-1	1986	Following intravenous infusion, angiotensin I (ANG I), angiotensin II (ANG II), and angiotensin III (ANG III) enhance Na and water absorption across the jejunum by increasing sympathetic nerve activity.	Water	125-130	angiogenin	Rattus norvegicus	71-74
21257712-11	2011	Reduction in AQP4 water transport may be protective in neuroinflammatory CNS diseases.	Water	18-23	aquaporin 4	Mus musculus	13-17
3020993-4	1986	At a dose of 100 pM, serosal addition of ANG II stimulated jejunal Na and water absorption.	Water	74-79	angiogenin	Rattus norvegicus	41-44
2946828-4	1986	Since the hypothalamus and septum are known to be critical areas for water and electrolyte balance, and blood pressure control, these results suggest that ANP plays a pathophysiological role in these brain regions of SHR.	Water	69-74	natriuretic peptide A	Rattus norvegicus	155-158
21291352-6	2011	The mRNA levels of MUTYH and MTH1 showed no significant change, whereas OGG1 mRNA was significantly decreased in ES-D7 treated with H(2)O(2).	Water	132-137	8-oxoguanine DNA-glycosylase 1	Mus musculus	72-76
3526340-2	1986	We used water-soluble carbodiimides to covalently attach the RNase S-peptide (residues 1-20) to [3H]RNase S-protein (residues 21-124) at unspecified locations.	Water	8-13	vitronectin	Homo sapiens	106-115
21576410-10	2011	The EtOAc fraction most strongly inhibited the receptor activator for nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis, followed by the n-BuOH, n-hexane and H(2)O fractions.	Water	172-177	TNF superfamily member 11	Homo sapiens	100-105
3488096-0	1986	Different receptor sites for Ca2+ and Na+ in single water fibers of the frog glossopharyngeal nerve.	Water	52-57	carbonic anhydrase 2	Homo sapiens	29-32
3488096-5	1986	The selective elimination by the pronase E treatment indicates that there exist different receptor sites for Ca2+ and Na+ in single water fibers of the frog glossopharyngeal nerve.	Water	132-137	carbonic anhydrase 2	Homo sapiens	109-112
2941540-0	1986	Observations on the natriuretic response to intravenous infusions of atrial natriuretic factor in water-loaded anaesthetized rats.	Water	98-103	natriuretic peptide A	Rattus norvegicus	69-94
20084436-6	2011	In a second part, to avoid the time consuming solvent extraction step, an analytical application to evaluate the performance of a direct analysis by laser induced fluorescence spectroscopy of ECDs traces in tap water and in raw water is presented.	Water	211-216	nuclear RNA export factor 1	Homo sapiens	207-210
21167196-5	2011	The MC3/MC4R antagonist SHU9119 increased food and water but had little effect on alcohol intake.	Water	51-56	melanocortin 4 receptor	Rattus norvegicus	8-12
20740302-6	2011	Expression of VEGF and water content in C6/VEGF- glioma (C6/VEGF-G) tissues were lower than in C6, C6/VEGF+, and C6/vec glioma (C6G, C6/VEGF+G, C6/vecG) (P &lt; 0.01, P &lt; 0.05); water content correlated with VEGF expression (r = 0.791, P = 0.000).	Water	23-28	vascular endothelial growth factor A	Mus musculus	43-47
2941540-1	1986	Natriuresis induced by infusions of atrial natriuretic factor (ANF) in water-loaded rats typically occurred in time sequences ("peak-and-shoulder" patterns) with an overlap of two different natriuretic responses.	Water	71-76	natriuretic peptide A	Rattus norvegicus	36-61
20740302-6	2011	Expression of VEGF and water content in C6/VEGF- glioma (C6/VEGF-G) tissues were lower than in C6, C6/VEGF+, and C6/vec glioma (C6G, C6/VEGF+G, C6/vecG) (P &lt; 0.01, P &lt; 0.05); water content correlated with VEGF expression (r = 0.791, P = 0.000).	Water	23-28	vascular endothelial growth factor A	Mus musculus	43-47
2941540-1	1986	Natriuresis induced by infusions of atrial natriuretic factor (ANF) in water-loaded rats typically occurred in time sequences ("peak-and-shoulder" patterns) with an overlap of two different natriuretic responses.	Water	71-76	natriuretic peptide A	Rattus norvegicus	63-66
20740302-6	2011	Expression of VEGF and water content in C6/VEGF- glioma (C6/VEGF-G) tissues were lower than in C6, C6/VEGF+, and C6/vec glioma (C6G, C6/VEGF+G, C6/vecG) (P &lt; 0.01, P &lt; 0.05); water content correlated with VEGF expression (r = 0.791, P = 0.000).	Water	23-28	vascular endothelial growth factor A	Mus musculus	43-47
20740302-6	2011	Expression of VEGF and water content in C6/VEGF- glioma (C6/VEGF-G) tissues were lower than in C6, C6/VEGF+, and C6/vec glioma (C6G, C6/VEGF+G, C6/vecG) (P &lt; 0.01, P &lt; 0.05); water content correlated with VEGF expression (r = 0.791, P = 0.000).	Water	23-28	vascular endothelial growth factor A	Mus musculus	43-47
20740302-6	2011	Expression of VEGF and water content in C6/VEGF- glioma (C6/VEGF-G) tissues were lower than in C6, C6/VEGF+, and C6/vec glioma (C6G, C6/VEGF+G, C6/vecG) (P &lt; 0.01, P &lt; 0.05); water content correlated with VEGF expression (r = 0.791, P = 0.000).	Water	23-28	vascular endothelial growth factor A	Mus musculus	43-47
21214248-1	2011	The heterolytic dissociation of water with the previously unknown four-coordinated syn-linear (mu-oxo)divanadium core to form the five-coordinated bis(mu-hydroxo)divanadium core was confirmed by a crystal-to-crystal transformation.	Water	32-37	synemin	Homo sapiens	83-86
3010990-0	1986	Spin-trapping of superoxide ion by a water-soluble, nitroso-aromatic spin-trap.	Water	37-42	spindlin 1	Homo sapiens	0-4
21222449-2	2011	This assumption is due to the high water solubility of SRB relative to most fluorescent probes.	Water	35-40	chaperonin containing TCP1 subunit 4	Homo sapiens	55-58
21222449-3	2011	However, in the present study, we demonstrate that SRB is in fact an amphiphile, with the ability to adsorb at an air/water interface and to incorporate into sodium dodecyl sulfate (SDS) micelles.	Water	118-123	chaperonin containing TCP1 subunit 4	Homo sapiens	51-54
21222449-4	2011	In fact, SRB reduces the surface tension of water by up to 23 mN/m, and the addition of SRB to an aqueous SDS solution induces a significant decrease in the cmc of SDS.	Water	44-49	chaperonin containing TCP1 subunit 4	Homo sapiens	9-12
21222449-6	2011	The simulations revealed that SRB has defined polar "head" and nonpolar "tail" regions when adsorbed at the air/water interface as a monomer.	Water	112-117	chaperonin containing TCP1 subunit 4	Homo sapiens	30-33
21303170-1	2011	Water self-diffusion within human aquaporin 4 has been studied using molecular dynamics (MD) simulations in the absence and presence of external ac and dc electric fields.	Water	0-5	aquaporin 4	Homo sapiens	34-45
21115195-9	2011	The presence of elastin within the pores of PCL improved the water uptake properties of PCL scaffolds; the water uptake ratio of PCL was enhanced 100-fold from 0.030 +- 0.005g liquid/g polymer to 11.80 +- 0.01g liquid/g polymer, when the elastin solution concentration was 50mg/ml.	Water	61-66	elastin	Homo sapiens	16-23
21115195-9	2011	The presence of elastin within the pores of PCL improved the water uptake properties of PCL scaffolds; the water uptake ratio of PCL was enhanced 100-fold from 0.030 +- 0.005g liquid/g polymer to 11.80 +- 0.01g liquid/g polymer, when the elastin solution concentration was 50mg/ml.	Water	61-66	PHD finger protein 1	Homo sapiens	44-47
21115195-9	2011	The presence of elastin within the pores of PCL improved the water uptake properties of PCL scaffolds; the water uptake ratio of PCL was enhanced 100-fold from 0.030 +- 0.005g liquid/g polymer to 11.80 +- 0.01g liquid/g polymer, when the elastin solution concentration was 50mg/ml.	Water	61-66	PHD finger protein 1	Homo sapiens	88-91
21115195-9	2011	The presence of elastin within the pores of PCL improved the water uptake properties of PCL scaffolds; the water uptake ratio of PCL was enhanced 100-fold from 0.030 +- 0.005g liquid/g polymer to 11.80 +- 0.01g liquid/g polymer, when the elastin solution concentration was 50mg/ml.	Water	61-66	PHD finger protein 1	Homo sapiens	88-91
21115195-9	2011	The presence of elastin within the pores of PCL improved the water uptake properties of PCL scaffolds; the water uptake ratio of PCL was enhanced 100-fold from 0.030 +- 0.005g liquid/g polymer to 11.80 +- 0.01g liquid/g polymer, when the elastin solution concentration was 50mg/ml.	Water	107-112	elastin	Homo sapiens	16-23
21115195-9	2011	The presence of elastin within the pores of PCL improved the water uptake properties of PCL scaffolds; the water uptake ratio of PCL was enhanced 100-fold from 0.030 +- 0.005g liquid/g polymer to 11.80 +- 0.01g liquid/g polymer, when the elastin solution concentration was 50mg/ml.	Water	107-112	PHD finger protein 1	Homo sapiens	44-47
21115195-9	2011	The presence of elastin within the pores of PCL improved the water uptake properties of PCL scaffolds; the water uptake ratio of PCL was enhanced 100-fold from 0.030 +- 0.005g liquid/g polymer to 11.80 +- 0.01g liquid/g polymer, when the elastin solution concentration was 50mg/ml.	Water	107-112	PHD finger protein 1	Homo sapiens	88-91
21115195-9	2011	The presence of elastin within the pores of PCL improved the water uptake properties of PCL scaffolds; the water uptake ratio of PCL was enhanced 100-fold from 0.030 +- 0.005g liquid/g polymer to 11.80 +- 0.01g liquid/g polymer, when the elastin solution concentration was 50mg/ml.	Water	107-112	PHD finger protein 1	Homo sapiens	88-91
21115195-10	2011	These composites exhibited lower compressive modulus and energy loss compared to pure PCL scaffolds due to their higher water content and elasticity.	Water	120-125	PHD finger protein 1	Homo sapiens	86-89
21067820-3	2011	The finding that most NMO patients have auto-antibodies against aquaporin-4, a water channel particularly abundant on the astrocytes of the glia limitans, has allowed early diagnosis and specific treatment of these patients, and has greatly improved our knowledge of its pathogenesis.	Water	79-84	aquaporin 4	Homo sapiens	64-75
21254278-3	2011	Co-incubation with 5 mM NAC significantly (P&lt;0.001) reduced the germ cell apoptosis induced by 10 microM H(2)O(2).	Water	108-113	X-linked Kx blood group	Homo sapiens	24-27
21135743-4	2011	Tap water was infused via a metal trocar for approximately 60 minutes.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
21093573-3	2011	In the present study, we investigated the capability of water-extracted H. erinaceum (WEHE) to induce the expression of intercellular adhesion molecule-1 (ICAM-1), which regulates the migration of immune cells.	Water	56-61	intercellular adhesion molecule 1	Homo sapiens	155-161
20740302-6	2011	Expression of VEGF and water content in C6/VEGF- glioma (C6/VEGF-G) tissues were lower than in C6, C6/VEGF+, and C6/vec glioma (C6G, C6/VEGF+G, C6/vecG) (P &lt; 0.01, P &lt; 0.05); water content correlated with VEGF expression (r = 0.791, P = 0.000).	Water	181-186	vascular endothelial growth factor A	Mus musculus	14-18
21489107-6	2011	Although attached hp1 leaves had enhanced gs, E and A compared to control leaves, genotypic differences were lost when water was withheld.	Water	119-124	DNA damage-binding protein 1	Solanum lycopersicum	18-21
21514620-5	2011	NDMA-FP Cl2 was evaluated by chlorinating water samples with free chlorine for 24 h at pH 7.0 while residual free chlorine was kept at 1.0-2.0 mg Cl(2)/L.	Water	42-47	endogenous retrovirus group W member 5	Homo sapiens	8-11
21552523-1	2011	Aquaporin-4 (AQP4) is a water channel expressed at the sarcolemma of fast-twitch skeletal muscle fibers, whose expression is altered in several forms of muscular dystrophies.	Water	24-29	aquaporin 4	Mus musculus	0-11
21552523-1	2011	Aquaporin-4 (AQP4) is a water channel expressed at the sarcolemma of fast-twitch skeletal muscle fibers, whose expression is altered in several forms of muscular dystrophies.	Water	24-29	aquaporin 4	Mus musculus	13-17
21552523-9	2011	Together these findings suggest AQP4 as a novel determinant in the regulation of skeletal muscle metabolism and better define the role of this water channel in skeletal muscle physiology.	Water	143-148	aquaporin 4	Mus musculus	32-36
21217061-6	2011	High-glucose-induced upregulation of NQO1, GCLC, and HMOX1 was also prevented by pretreatment with polyethylene glycol (PEG)-catalase or N-acetylcysteine, whereas administration of H(2)O(2) mimicked the effect of high glucose.	Water	181-186	NAD(P)H dehydrogenase, quinone 1	Mus musculus	37-41
21255608-6	2011	Oxalate oxidase (OxOx) is a commonly occurring enzyme in plants, bacteria and fungi that catalyses oxidative cleavage of oxalate to CO(2) with reduction of dioxygen to H(2)O(2).	Water	168-173	germin-like protein 8-4	Triticum aestivum	0-15
21255608-6	2011	Oxalate oxidase (OxOx) is a commonly occurring enzyme in plants, bacteria and fungi that catalyses oxidative cleavage of oxalate to CO(2) with reduction of dioxygen to H(2)O(2).	Water	168-173	germin-like protein 8-4	Triticum aestivum	17-21
21421769-0	2011	European tap water position statement released.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
21178974-8	2011	The mCCD(c11) cell line is a first example of a mammalian tight epithelium allowing quantitative study of the coupling between sodium and water transport.	Water	138-143	RNA polymerase III subunit K	Homo sapiens	9-12
21370374-0	2011	Hydration of carbonyl groups: the labile H3O+ ion as an intermediate modulated by the surrounding water molecules.	Water	98-103	H3 clustered histone 15	Homo sapiens	41-44
21306115-1	2011	4-Fluoro-1,2-benzoquinone, generated by tyrosinase oxidation of 4-fluorocatechol in aqueous buffer, rapidly undergoes substitution by O-nucleophiles (water or catechols) with release of fluoride.	Water	150-155	tyrosinase	Homo sapiens	40-50
21410938-2	2011	Exposure occurs from consumption of tap water, inhalation and dermal absorption.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
21315897-0	2011	A hybrid mesoporous material functionalized by 1,8-naphthalimide-base receptor and the application as chemosensor and absorbent for Hg2+ in water.	Water	140-145	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	132-135
21319828-10	2011	For low PIL concentrations, the water was predominately present as bulk water for PIL molar fractions less than 0.4-0.5.	Water	32-37	serpin family A member 2 (gene/pseudogene)	Homo sapiens	8-11
21319828-10	2011	For low PIL concentrations, the water was predominately present as bulk water for PIL molar fractions less than 0.4-0.5.	Water	32-37	serpin family A member 2 (gene/pseudogene)	Homo sapiens	82-85
21319828-10	2011	For low PIL concentrations, the water was predominately present as bulk water for PIL molar fractions less than 0.4-0.5.	Water	72-77	serpin family A member 2 (gene/pseudogene)	Homo sapiens	82-85
21319828-11	2011	At high PIL concentrations, in addition to the bulk water, there was a significant proportion of perturbed water, which is water influenced in some way by the cations and anions.	Water	107-112	serpin family A member 2 (gene/pseudogene)	Homo sapiens	8-11
21319828-11	2011	At high PIL concentrations, in addition to the bulk water, there was a significant proportion of perturbed water, which is water influenced in some way by the cations and anions.	Water	107-112	serpin family A member 2 (gene/pseudogene)	Homo sapiens	8-11
21338763-8	2011	Apparent recoveries obtained by the proposed method in tap water and tea extracts were (82-103)% and (89-99)%, respectively.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
21282342-0	2011	Glucose monitoring after fruit peeling: pseudohyperglycemia when neglecting hand washing before fingertip blood sampling: wash your hands with tap water before you check blood glucose level.	Water	147-152	nuclear RNA export factor 1	Homo sapiens	143-146
22066282-3	2011	150 houses in two different areas, one supplied by bore well and other by tap water was selected by modified cluster sampling.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
22434982-8	2011	Twenty (57.1%) household water samples and 9 (25.7%) of the tap water samples had no residual free chlorine.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
22434982-10	2011	Eight (22.9%) tap water samples had low risk score for total coliforms whereas 21(60%) tap water had very low risk score for thermotolerant coliforms.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
22434982-10	2011	Eight (22.9%) tap water samples had low risk score for total coliforms whereas 21(60%) tap water had very low risk score for thermotolerant coliforms.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
22434982-12	2011	CONCLUSION: Water supplies at tap and household water containers were contaminated with bacteria.	Water	12-17	nuclear RNA export factor 1	Homo sapiens	30-33
21318627-3	2011	The PCL/HA-AL microspheres were prepared with solid/oil/water emulsion technique, which included two processes: (1) AL was loaded on the hydroxyapatite nanoparticles; (2) the HA-AL complex was built in the PCL matrix.	Water	56-61	PHD finger protein 1	Homo sapiens	4-7
21150871-3	2011	Here, we report that Am580, a water-soluble RARalpha-specific agonist, attenuated proteinuria, glomerosclerosis, and podocyte proliferation, and restored podocyte differentiation markers in kidneys of Tg26 mice.	Water	30-35	retinoic acid receptor, alpha	Mus musculus	44-52
21257342-5	2011	The proposed sensor was then applied for the determination of zinc in tap water and hair samples with satisfactory results.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
21227579-3	2011	A qualitative estimation of the flow pattern in the outlet pipe using the map of Taitel and Dukler suggests that these air/water flows are intermittent flows--presumably slug flows--evolving to annular flows for qualities above 0.1.	Water	123-128	snail family transcriptional repressor 2	Homo sapiens	170-174
3010990-0	1986	Spin-trapping of superoxide ion by a water-soluble, nitroso-aromatic spin-trap.	Water	37-42	spindlin 1	Homo sapiens	69-73
3010990-1	1986	Spin-trapping of superoxide ion, O2-, which is produced from two different sources (OH(-)-DMSO and xanthine-xanthine oxidase systems), was investigated by use of a water-soluble, notroso-aromatic spin trap, sodium 3,5-dibromo-4-nitrosobenzene-sulfonate (DBNBS).	Water	164-169	spindlin 1	Homo sapiens	0-4
3958498-0	1986	Washing of ELISA plates with running tap water.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
3457525-7	1986	Intensity of aerosolization directly correlated with the degree of L. pneumophila contamination of the tap water used to fill the humidifier.	Water	107-112	nuclear RNA export factor 1	Homo sapiens	103-106
21245536-5	2011	According to structural analysis, the trypsin-BPTI interfaces located at the scissile peptide and the active sites were inaccessible to solvent water, and the amide H atoms of P2" Arg17/I, Gly216/E and Gly193/E at the binding interface were protected from H/D exchange.	Water	144-149	spleen trypsin inhibitor I	Bos taurus	46-50
21155863-7	2011	Enhanced sodium and water reabsorption, occurring as a consequence of endogenous or pharmacological stimulation of the peroxisome proliferator-activated receptor gamma is Sgk1 mediated.	Water	20-25	serum/glucocorticoid regulated kinase 1	Homo sapiens	171-175
21220345-2	2011	We show that inositol polyphosphate multikinase (IPMK) physiologically generates PIP(3) as well as water soluble inositol phosphates.	Water	99-104	inositol polyphosphate multikinase	Homo sapiens	13-47
3457525-8	1986	Rinsing of ventilation bag apparatus with tap water led to isolation of L. pneumophila from culture plates after the ventilation bags were squeezed.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
21220345-2	2011	We show that inositol polyphosphate multikinase (IPMK) physiologically generates PIP(3) as well as water soluble inositol phosphates.	Water	99-104	inositol polyphosphate multikinase	Homo sapiens	49-53
3953506-2	1986	This method, using an unmodified microwave oven and a tap-water environment, decreases thawing time from 37.5 minutes for the standard 37 degrees C water bath to approximately 11 minutes for either one or two units of FFP.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
21522881-1	2011	In the polymeric title compound, [Ca(C(7)H(3)NO(4))(H(2)O)(C(2)H(6)OS)](n), the Ca(II) ion is coordinated in a distorted penta-gonal-bipyramidal CdNO(6) geometry.	Water	52-57	carbonic anhydrase 2	Homo sapiens	80-86
20944548-2	2011	From initial studies on the effects of secretin (SCT) on renal water reabsorption in the 1940s and recent investigations of its role in cardiovascular and neuroendocrine functions, it has now become increasingly clear that this peptide is an integral component of the homeostatic processes that maintain body fluid balance.	Water	63-68	secretin	Homo sapiens	39-47
20944548-2	2011	From initial studies on the effects of secretin (SCT) on renal water reabsorption in the 1940s and recent investigations of its role in cardiovascular and neuroendocrine functions, it has now become increasingly clear that this peptide is an integral component of the homeostatic processes that maintain body fluid balance.	Water	63-68	secretin	Homo sapiens	49-52
20944548-3	2011	This review, containing some of our recent findings of centrally expressed SCT on water intake, focuses on the actions of SCT in influencing the physiological, neuroendocrine, and cardiovascular processes that subserve body fluid homeostasis.	Water	82-87	secretin	Homo sapiens	75-78
3953506-2	1986	This method, using an unmodified microwave oven and a tap-water environment, decreases thawing time from 37.5 minutes for the standard 37 degrees C water bath to approximately 11 minutes for either one or two units of FFP.	Water	148-153	nuclear RNA export factor 1	Homo sapiens	54-57
3707186-4	1986	Scalds usually followed spillage from kitchen containers in accidents and forced tap water immersion in cases of abuse.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
21220402-9	2011	Factors that influence maternal water consumption or other contaminants in tap or bottled water might explain this finding.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	75-78
21047522-8	2011	Deletion of MMP-9 decreased the levels of endostatin in both water- and DSS-treated MMP-9 KO mice.	Water	61-66	collagen, type XVIII, alpha 1	Mus musculus	42-52
21725748-1	2011	OBJECTIVE: There is mounting evidence suggesting that arginine vasopressin via its V1a receptor interaction is involved in the regulation of the brain water channel, aquaporin-4 (AQP4).	Water	151-156	aquaporin 4	Mus musculus	166-177
21725748-1	2011	OBJECTIVE: There is mounting evidence suggesting that arginine vasopressin via its V1a receptor interaction is involved in the regulation of the brain water channel, aquaporin-4 (AQP4).	Water	151-156	aquaporin 4	Mus musculus	179-183
21185056-2	2011	Biofouling was stimulated by the use of tap water enriched with acetate at a range of concentrations (1-1000 mugCl(-1)).	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
3093095-6	1986	Treatment with D,L-alpha-difluoromethylornithine X HCl X H2O (DFMO), a specific irreversible inhibitor of ODC activity, completely abrogated lymphokine-dependent ODC induction in both the CTLL-20 and FDC-P1 cell lines.	Water	57-60	ornithine decarboxylase, structural 1	Mus musculus	106-109
21725748-2	2011	The role of AQP4 in brain edema resolution has been thoroughly investigated in knock-out animal studies, which showed that its depletion increases brain water content in models of vasogenic edema.	Water	153-158	aquaporin 4	Mus musculus	12-16
21046080-7	2011	The feasibility of the method for the determination of analytes in water samples was checked in tap water and untreated and treated wastewater.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	96-99
21283711-2	2011	In these cells, inwardly rectifying potassium (Kir) channels and aquaporin-4 water channels play an important role in the process of spatial potassium buffering and water drainage.	Water	77-82	aquaporin 4	Mus musculus	65-76
3093095-6	1986	Treatment with D,L-alpha-difluoromethylornithine X HCl X H2O (DFMO), a specific irreversible inhibitor of ODC activity, completely abrogated lymphokine-dependent ODC induction in both the CTLL-20 and FDC-P1 cell lines.	Water	57-60	ornithine decarboxylase, structural 1	Mus musculus	162-165
21283711-2	2011	In these cells, inwardly rectifying potassium (Kir) channels and aquaporin-4 water channels play an important role in the process of spatial potassium buffering and water drainage.	Water	165-170	aquaporin 4	Mus musculus	65-76
3081775-4	1986	The ovine corticotropin releasing factor (oCRF 41) decreased food and water intake by 30-50% when administered ICV (60 ng/kg) but was not active when given systemically at doses up to 6 micrograms/kg.	Water	70-75	corticoliberin	Ovis aries	10-40
21228491-2	2011	The Rv3378c-encoded enzyme produced tuberculosinol 2 (5(6), 13(14)-halimadiene-15-ol), 13R-5a and 13S-isotuberculosinol 5b (5(6), 14(15)-halimadiene-13-ol) as its enzymatic products from tuberculosinyl diphosphate 3, indicating that the Rv3378c enzyme catalyzed the nucleophilic addition of a water molecule after the release of a diphosphate moiety.	Water	293-298	diterpene synthase	Mycobacterium tuberculosis H37Rv	4-11
21280976-10	2011	CONCLUSION: These findings suggest that the reduction of spinal cord oedema in response to SFN administration could be due, in part, to water clearance by AQP4 from the injured spinal cord segments.	Water	136-141	aquaporin 4	Mus musculus	155-159
22116364-7	2011	Interestingly, the water channel AQP5 was recently found to be expressed at the apical side of B-ICs, in the absence of a basolateral water channel, and pendrin and AQP5 membrane expressions are both inhibited by K(+) depletion, suggesting that pendrin and AQP5 could cooperate to regulate cell volume, a potent stimulus of ATP release.	Water	19-24	aquaporin 5	Mus musculus	33-37
21241149-7	2011	However, AA c(555) has the lowest packing efficiency of heme and the apo polypeptide with hololike structure, which is unfavorable for the water entropy.	Water	139-144	glycine-N-acyltransferase	Homo sapiens	9-13
2939934-5	1986	These data suggest that the substance inhibiting the intestinal absorption of water and solutes is probably atrial natriuretic factor and that it acts on the sodium-dextrose cotransport mechanism.	Water	78-83	natriuretic peptide A	Rattus norvegicus	108-133
20625739-13	2011	Aquaporin-4 is expressed at the ependyma, glia limitans, and at the perivascular end feet processes of astrocytes of the BBB, facilitating the water movement across these tissue interfaces.	Water	143-148	aquaporin 4	Mus musculus	0-11
3947759-0	1986	Potential formation of bromophenols in Barcelona"s tap water due to daily salt mine discharges and occasional phenol spills.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
20864894-4	2011	She wore extended wear soft contact lenses and frequently rinsed her eyes with tap water.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
20950592-6	2011	Our results demonstrated a significant reduction in brain infarction volume, brain water content, and neurobehavioral deficits following LV-mmp9shRNA treatment.	Water	83-88	matrix metallopeptidase 9	Rattus norvegicus	140-144
3514385-0	1986	[Deficiencies in the method for the sanitary bacteriological analysis of chlorinated tap water].	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
20933058-2	2011	Abeta1-42 injection induces loss of learning and memory behavior of rats in Morris water maze, which could be reversed with Rb1 treatment.	Water	83-88	RB transcriptional corepressor 1	Rattus norvegicus	124-127
21128590-1	2011	A low-abundance form of water, H(2)(17)O, was enriched from 0.04% to ~90% by slow evaporation and fractional distillation of tap water.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	125-128
21976981-4	2011	For the current study, Hartree-Fock calculations were used to investigate the solvent-induced effects of five different solvent media (acetone, ethanol, methanol, dimethyl sulfoxide, and water) on the thermochemical parameters and relative energies, and on the multinuclear nuclear magnetic resonance shielding tensors of oxygen, nitrogen, and phosphorus nuclei, of GAT.	Water	187-192	glycine-N-acyltransferase	Homo sapiens	366-369
21976981-8	2011	Another important objective of this study was to compare the hydration Gibbs free energies of CUA and GAT in water using two different approaches where the solvent was treated as a continuum of the constant at different levels of Hartree-Fock theory.	Water	109-114	glycine-N-acyltransferase	Homo sapiens	102-105
21976981-10	2011	The clustered structures of water molecules around the hot spots of GAT (in DNA level) and CUA (in transcriptional level) were found to be energetically favored.	Water	28-33	glycine-N-acyltransferase	Homo sapiens	68-71
21128590-1	2011	A low-abundance form of water, H(2)(17)O, was enriched from 0.04% to ~90% by slow evaporation and fractional distillation of tap water.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
3735792-11	1986	The whole body water loss is significantly correlated with the change in plasma volume and body temperatures (Tre, Tsk).	Water	15-20	tsukushi, small leucine rich proteoglycan	Homo sapiens	115-118
21415521-2	2011	PGA film was prepared on a cellulose acetate-coated Pt-Ir wire electrode, and GOx was covalently immobilized on its surface using water-soluble carbodiimide.	Water	130-135	hydroxyacid oxidase 1	Homo sapiens	78-81
22163171-0	2011	Evaluation of biochemical urinary stone composition and its relationship to tap water hardness in Qom province, central Iran.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
3520511-8	1986	These results indicate that the inhibition of renin secretion by vasopressin in anesthetized water-loaded dogs is due to its antidiuretic activity.	Water	93-98	renin	Canis lupus familiaris	46-51
22403982-4	2011	Source tap water was cycled through the lines at 1.4 mL/minute, five minutes on and 25 minutes off, eight hours/day, five days/week.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
22403982-11	2011	Further research on N-halamine tubing using a pure water source is recommended, as T effluent bacterial levels reflected the source tap water quality and proliferation of planktonic bacteria with no biofilm activity.	Water	136-141	nuclear RNA export factor 1	Homo sapiens	132-135
22255225-2	2011	This paper discusses the hydrodynamics of deformation dependent vortices that develop inside a water-in-oil slug as it flows through a channel.	Water	95-100	snail family transcriptional repressor 2	Homo sapiens	108-112
4073264-2	1985	AVP was infused intravenously at 0.1, 0.2, and 0.5 microgram/h for 24-48 h in sheep allowed free access to water.	Water	107-112	vasopressin-neurophysin 2-copeptin	Ovis aries	0-3
22184507-0	2011	Water Temperature From Hot Water Outlets in a Major Public Hospital: How Hot is Our Water?	Water	0-5	alcohol dehydrogenase iron containing 1	Homo sapiens	23-26
22184507-0	2011	Water Temperature From Hot Water Outlets in a Major Public Hospital: How Hot is Our Water?	Water	0-5	alcohol dehydrogenase iron containing 1	Homo sapiens	73-76
22184507-10	2011	After this adjustment, outlets previously supplying excessively hot water were re-tested and found to be safe, closing the audit loop.	Water	68-73	alcohol dehydrogenase iron containing 1	Homo sapiens	64-67
21339176-1	2011	Water channel aquaporin-4 (AQP4) is the most abundant water channel in the rodent brain and is mainly expressed in cerebral areas involved in central osmoreception and osmoregulation.	Water	0-5	aquaporin 4	Mus musculus	14-25
21339176-1	2011	Water channel aquaporin-4 (AQP4) is the most abundant water channel in the rodent brain and is mainly expressed in cerebral areas involved in central osmoreception and osmoregulation.	Water	0-5	aquaporin 4	Mus musculus	27-31
21339176-1	2011	Water channel aquaporin-4 (AQP4) is the most abundant water channel in the rodent brain and is mainly expressed in cerebral areas involved in central osmoreception and osmoregulation.	Water	54-59	aquaporin 4	Mus musculus	14-25
21339176-1	2011	Water channel aquaporin-4 (AQP4) is the most abundant water channel in the rodent brain and is mainly expressed in cerebral areas involved in central osmoreception and osmoregulation.	Water	54-59	aquaporin 4	Mus musculus	27-31
4073264-5	1985	Plasma AVP levels induced by these infusions were 9.8 +/- 1.6 (0.1 microgram/h AVP), 21.9 +/- 7.7 (0.2 microgram/h AVP), and 32.5 +/- 9.0 pg/ml (0.5 microgram/h AVP) after 24 h. These concentrations are within the range found in sheep deprived of water for 3 days.	Water	247-252	vasopressin-neurophysin 2-copeptin	Ovis aries	7-10
4052444-1	1985	A water-soluble derivative of cholesterol, methoxypolyoxyethylated (MPOE) cholesterol, has been synthesized and used to study the regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the key regulatory enzyme in cholesterol biosynthesis.	Water	2-7	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	144-201
21461556-0	2011	Identification of a novel function of Id-1 in mediating the anticancer responses of SAMC, a water-soluble garlic derivative, in human bladder cancer cells.	Water	92-97	solute carrier family 25 member 26	Homo sapiens	84-88
21461556-2	2011	S-allylmercaptocysteine (SAMC), a water-soluble component of garlic, is known to have a potent therapeutic effect on human cancer.	Water	34-39	solute carrier family 25 member 26	Homo sapiens	25-29
21850155-3	2011	METHODS: EAU was induced in 18 B10RIII mice with 25 microg of inter-photoreceptor retinoid-binding protein (IRBP) emulsified with complete Freund"s adjuvant (CFA); 18 mice treated with CFA without IRBP served as controls.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	62-106
21850155-3	2011	METHODS: EAU was induced in 18 B10RIII mice with 25 microg of inter-photoreceptor retinoid-binding protein (IRBP) emulsified with complete Freund"s adjuvant (CFA); 18 mice treated with CFA without IRBP served as controls.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	108-112
21850155-3	2011	METHODS: EAU was induced in 18 B10RIII mice with 25 microg of inter-photoreceptor retinoid-binding protein (IRBP) emulsified with complete Freund"s adjuvant (CFA); 18 mice treated with CFA without IRBP served as controls.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	197-201
22187667-8	2011	Next to Cl(-) ion is a hydrogen bonded water molecule W-7" which in turn is hydrogen bonded to W-8" and N atom of SCN(-).	Water	39-44	sorcin	Homo sapiens	114-117
22187667-10	2011	SCN(-) ion also interacts directly with Asn-230 and through water molecules with Ser-235 and Phe-254.	Water	60-65	sorcin	Homo sapiens	0-3
21891870-1	2011	Aquaporin-4 (AQP4) is the predominant water channel in brain and is selectively expressed in astrocytes.	Water	38-43	aquaporin 4	Mus musculus	0-11
2937944-0	1985	[Chronic effects of synthetic rat atrial natriuretic factor (ANF) on blood pressure and sodium-water excretion in conscious rats].	Water	95-100	natriuretic peptide A	Rattus norvegicus	61-64
21891870-1	2011	Aquaporin-4 (AQP4) is the predominant water channel in brain and is selectively expressed in astrocytes.	Water	38-43	aquaporin 4	Mus musculus	13-17
21311200-8	2011	The HAL manikin needed 26 cm H2O (19-31) and 24 cm H2O (22-33), respectively.	Water	29-32	histidine ammonia-lyase	Homo sapiens	4-7
4074687-1	1985	Carbon-13 NMR longitudinal relaxation time and line-width studies are reported on the coacervate concentration (about 60% water by weight) of singly carbonyl carbon enriched polypentapeptides of elastin: specifically, (L-Val1-L-[1-13C]Pro2-Gly3-L-Val4-Gly5)n and (L-Val1-L-Pro2-Gly3-L-Val4-[1-13C]Gly5)n. On raising the temperature from 10 to 25 degrees C and from 40 to 70 degrees C, carbonyl mobility increases, but over the temperature interval from 25 to 40 degrees C, the mobility decreases.	Water	122-127	elastin	Homo sapiens	195-202
21311200-8	2011	The HAL manikin needed 26 cm H2O (19-31) and 24 cm H2O (22-33), respectively.	Water	51-54	histidine ammonia-lyase	Homo sapiens	4-7
21747732-0	2011	An environmental friendly procedure for photometric determination of hypochlorite in tap water employing a miniaturized multicommuted flow analysis setup.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
4062363-6	1985	Tap water and infant blood lead levels correlated minimally (r = .11, P = .10).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
21747732-1	2011	A photometric procedure for the determination of ClO(-) in tap water employing a miniaturized multicommuted flow analysis setup and an LED-based photometer is described.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
22039440-5	2011	RESULTS: Cysteamine administration (150 mg/kg/day, through drinking water) for 21 days significantly ameliorated chronic corticosterone-induced decreases in TrkB protein levels in frontal cortex and hippocampus.	Water	68-73	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	157-161
21090654-3	2010	An indolenine intermediate is implicated in the addition step, and surprisingly, water cosolvent was found to have a beneficial effect in this step, leading to a one-pot protocol for elimination/enantioselective addition using PBAM, a bis(amidine) chiral nonracemic base.	Water	81-86	solute carrier family 10 member 2	Homo sapiens	227-231
21660137-4	2011	Tap water was given as a control.	Water	4-9	SEC14-like lipid binding 2	Rattus norvegicus	0-3
3000086-5	1985	In the field, the developed method was used for testing water specimens from various water bodies (sewage, river water, tap water).	Water	56-61	nuclear RNA export factor 1	Homo sapiens	120-123
21660137-6	2011	was administered after 2 days of OJ, hesperidin, or tap water ingestion.	Water	56-61	SEC14-like lipid binding 2	Rattus norvegicus	52-55
21090606-0	2010	Perchlorate, nitrate, and iodide intake through tap water.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
20970221-0	2010	2-Hydroxypropyl-beta-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.	Water	52-57	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	135-138
4065204-2	1985	Arginine vasopressin (AVP) 100 microU/ml increased hydrosmotic water permeability (Pf, 10(-3) cm/s) by 11.4 +/- 1.59.	Water	63-68	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	22-25
20213667-3	2011	A significant part of the pharmacophore hypothesis used in this study was designed by mimicking water-mediated PPI relevant in the CMK homodimer complex stabilization.	Water	96-101	cytidine/uridine monophosphate kinase 1	Homo sapiens	131-134
20659533-1	2010	A water-soluble polysaccharide LT1 was isolated from the basidiocarps of Lentinus edodes by hot water extraction and ethanol precipitations, further purified by gel chromatography.	Water	2-7	lurcher transcript 1	Mus musculus	31-34
20965221-7	2011	In addition, water deprivation induced more c-fos expression in the central dipsogenic areas, including the paraventricular and supraoptic nuclei in the offspring exposed to prenatal high sucrose.	Water	13-18	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	44-49
2996585-11	1985	The ETF-QO-catalyzed comproportionation reaction exhibits a primary deuterium isotope effect in D2O, perhaps indicating the participation of solvent water in the electron-transfer reaction.	Water	149-154	electron transfer flavoprotein dehydrogenase	Homo sapiens	4-10
21698155-8	2011	The present guidelines for fluoridated tap water might be reconsidered accordingly, particularly around Mt Vesuvius and in other fluoride hazard areas with high natural fluoride levels.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
21697964-7	2011	Tap water at a flow rate of 10 L/h was infused through the arterial tubings.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
21411934-4	2011	Composting toilets and low-flow tap fittings further reduce the water demand.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	32-35
20659533-1	2010	A water-soluble polysaccharide LT1 was isolated from the basidiocarps of Lentinus edodes by hot water extraction and ethanol precipitations, further purified by gel chromatography.	Water	96-101	lurcher transcript 1	Mus musculus	31-34
20659533-4	2010	AFM and Congo-red test revealed that LT1 existed as triple helix chain in 0.10 M NaOH solution or distilled water.	Water	108-113	lurcher transcript 1	Mus musculus	37-40
20667979-4	2010	Eighteen-month-old progranulin-deficient mice demonstrated impaired spatial learning and memory in the Morris water maze.	Water	110-115	granulin	Mus musculus	19-30
20864687-1	2010	Arginine vasopressin (AVP) enhances water reabsorption in the renal collecting duct by vasopressin V2 receptor (V2R)-mediated activation of adenylyl cyclase (AC), cAMP-promoted phosphorylation of aquaporin-2 (AQP2), and increased abundance of AQP2 on the apical membrane.	Water	36-41	arginine vasopressin receptor 2	Mus musculus	87-110
20739617-4	2010	Nevertheless, IRBP-specific T cells pre-exposed to PD-L1(hi) RPE cells displayed substantial suppressor activity, which strongly inhibited the activation of fresh IRBP-Teffs in response to subsequent antigenic challenge and when transferred into naive mice, inhibited the induction of EAU by IRBP-Teff transfer.	Water	285-288	retinol binding protein 3, interstitial	Mus musculus	14-18
21039668-1	2010	in spa water.	Water	7-12	surfactant protein A2	Homo sapiens	3-6
21039668-5	2010	in spa water.	Water	7-12	surfactant protein A2	Homo sapiens	3-6
21039668-15	2010	in spa water.	Water	7-12	surfactant protein A2	Homo sapiens	3-6
21039668-18	2010	in spa water with real-time PCR using a commercial quantitative PCR kit in a routine laboratory, when compared to conventional culture.	Water	7-12	surfactant protein A2	Homo sapiens	3-6
22097017-8	2011	The reason may lie in that PASP/ABSA copolymer simultaneously possesses carboxylic ion and sulfonic group which can chelate Ca2+ to form stabilized and dissoluble chelates, resulting in increase of solubility of calcium salts in water.	Water	229-234	carboxypeptidase B1	Homo sapiens	27-31
3157850-0	1985	Effects of changes in water-sodium balance on levels of atrial natriuretic factor messenger RNA and peptide in rats.	Water	22-27	natriuretic peptide A	Rattus norvegicus	56-81
21111143-6	2010	The developed method was applied for the analysis of tap water, mineral water, Pearl River water and honey.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
21112291-5	2010	Unexpectedly, however, only the C-terminal five of the eight Kras Lys side chains were found to directly interact with the bilayer, with the N-terminal ones staying in water.	Water	168-173	KRAS proto-oncogene, GTPase	Homo sapiens	61-65
20570123-5	2010	RESULTS: STW 33-I and the water-soluble Fr E showed concentration-dependent and significant anti-inflammatory effects in lipopolysaccharide-activated monocytes.	Water	26-31	frizzled related protein	Homo sapiens	40-44
3157850-2	1985	Specific changes in the level of ANF mRNA relative to total atrial RNA were observed in atria from sodium restricted rats and water deprived then sodium loaded rats, demonstrating an association of change in water-sodium balance with the expression of ANF gene.	Water	126-131	natriuretic peptide A	Rattus norvegicus	33-36
3157850-2	1985	Specific changes in the level of ANF mRNA relative to total atrial RNA were observed in atria from sodium restricted rats and water deprived then sodium loaded rats, demonstrating an association of change in water-sodium balance with the expression of ANF gene.	Water	208-213	natriuretic peptide A	Rattus norvegicus	33-36
21107133-8	2010	Both enhanced AQP4 expression and its unique staining pattern suggest that these proteins may be important in the impaired water transport observed in AD and CAA.	Water	123-128	aquaporin 4	Homo sapiens	14-18
21143683-2	2010	We previously identified TIP5;1 and TIP1;3 as the only Arabidopsis aquaporin genes that are selectively and highly expressed in mature pollen, and showed that they can transport both water and urea when expressed in Xenopus oocytes.	Water	183-188	tonoplast intrinsic protein 5;1	Arabidopsis thaliana	25-31
3157850-2	1985	Specific changes in the level of ANF mRNA relative to total atrial RNA were observed in atria from sodium restricted rats and water deprived then sodium loaded rats, demonstrating an association of change in water-sodium balance with the expression of ANF gene.	Water	208-213	natriuretic peptide A	Rattus norvegicus	252-255
21143683-2	2010	We previously identified TIP5;1 and TIP1;3 as the only Arabidopsis aquaporin genes that are selectively and highly expressed in mature pollen, and showed that they can transport both water and urea when expressed in Xenopus oocytes.	Water	183-188	Ankyrin repeat family protein with DHHC zinc finger domain-containing protein	Arabidopsis thaliana	36-40
3999986-6	1985	The free diffusion coefficient in water at 37 degrees of the purified 131I-albumin was 0.0631 X 10-5 cm2 X sec-1).	Water	34-39	secretory blood group 1, pseudogene	Homo sapiens	107-112
21143683-3	2010	Here, we show that TIP5;1 has unusual characteristics, as its water transport activity is regulated by pH.	Water	62-67	tonoplast intrinsic protein 5;1	Arabidopsis thaliana	19-25
21143683-4	2010	Analysis of the water transport activity of a mutant version of TIP5;1 (TIP5;1-H131A) and amino acid alignment with other plant aquaporins regulated by pH suggested that a conserved motif is involved in pH sensing.	Water	16-21	tonoplast intrinsic protein 5;1	Arabidopsis thaliana	64-70
21143683-4	2010	Analysis of the water transport activity of a mutant version of TIP5;1 (TIP5;1-H131A) and amino acid alignment with other plant aquaporins regulated by pH suggested that a conserved motif is involved in pH sensing.	Water	16-21	tonoplast intrinsic protein 5;1	Arabidopsis thaliana	64-69
20705979-4	2010	A series of one-way analysis of variance (ANOVA) tests suggest that the presence of children in a household and self-reported concern that tap water causes health problems lead to significantly greater consumption of bottled water or filtered water and significantly less tap water consumption.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
20705979-4	2010	A series of one-way analysis of variance (ANOVA) tests suggest that the presence of children in a household and self-reported concern that tap water causes health problems lead to significantly greater consumption of bottled water or filtered water and significantly less tap water consumption.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	272-275
20705979-4	2010	A series of one-way analysis of variance (ANOVA) tests suggest that the presence of children in a household and self-reported concern that tap water causes health problems lead to significantly greater consumption of bottled water or filtered water and significantly less tap water consumption.	Water	225-230	nuclear RNA export factor 1	Homo sapiens	139-142
20705979-4	2010	A series of one-way analysis of variance (ANOVA) tests suggest that the presence of children in a household and self-reported concern that tap water causes health problems lead to significantly greater consumption of bottled water or filtered water and significantly less tap water consumption.	Water	225-230	nuclear RNA export factor 1	Homo sapiens	139-142
3986264-3	1985	Plasma levels of Prl in incubating hens were significantly (P less than 0.05) reduced by nest deprivation either in the absence of feed and water or when the hens were force-fed the normal intake for a laying hen.	Water	140-145	prolactin	Gallus gallus	17-20
20705979-4	2010	A series of one-way analysis of variance (ANOVA) tests suggest that the presence of children in a household and self-reported concern that tap water causes health problems lead to significantly greater consumption of bottled water or filtered water and significantly less tap water consumption.	Water	225-230	nuclear RNA export factor 1	Homo sapiens	139-142
20705979-6	2010	Factors yielding higher probabilities of a respondent being primarily a bottled water drinker (relative to the choice of tap water) include: higher income, unpleasant taste experiences with tap water, non-French-speaking, and being a male with children in one"s household.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
20705979-6	2010	Factors yielding higher probabilities of a respondent being primarily a bottled water drinker (relative to the choice of tap water) include: higher income, unpleasant taste experiences with tap water, non-French-speaking, and being a male with children in one"s household.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
20705979-7	2010	Similar factors yield higher probabilities of a respondent being primarily a filtered tap water drinker.	Water	90-95	nuclear RNA export factor 1	Homo sapiens	86-89
20705979-8	2010	An important finding is that two key variables linking a person"s health perceptions regarding tap water quality are significant factors leading to the choice of either filtered tap water or bottled water over tap water.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
20705979-8	2010	An important finding is that two key variables linking a person"s health perceptions regarding tap water quality are significant factors leading to the choice of either filtered tap water or bottled water over tap water.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	178-181
20705979-8	2010	An important finding is that two key variables linking a person"s health perceptions regarding tap water quality are significant factors leading to the choice of either filtered tap water or bottled water over tap water.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	178-181
20705979-8	2010	An important finding is that two key variables linking a person"s health perceptions regarding tap water quality are significant factors leading to the choice of either filtered tap water or bottled water over tap water.	Water	182-187	nuclear RNA export factor 1	Homo sapiens	95-98
21438377-0	2010	[Application of solid phase extraction disk in the determination of acrylamide in tap water].	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
21438377-10	2010	The recovery for acrylamide spiked into a tap water sample was 79.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
21438377-12	2010	The method is simple, fast, sensitive and suitable for the determination of acrylamide in tap water.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
20973517-6	2010	The electrode was applicable for the analysis of spiked arsenic in tap water containing a significant amount of various other ion elements.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
2859326-5	1985	On the basis of these results, tap water is a likely source of the aeromonads found in human intestinal flora.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
20968297-5	2010	Special attention was given to adjusting for the coincidence of virus presence and use of tap water, as independently occurring short-term events within the longer interval that the virus is predicted to travel in any branch of the distribution system.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
20692763-0	2010	Biological and photocatalytic treatment integrated with separation and reuse of titanium dioxide on the removal of chlorophenols in tap water.	Water	136-141	nuclear RNA export factor 1	Homo sapiens	132-135
20705979-8	2010	An important finding is that two key variables linking a person"s health perceptions regarding tap water quality are significant factors leading to the choice of either filtered tap water or bottled water over tap water.	Water	182-187	nuclear RNA export factor 1	Homo sapiens	178-181
20705979-8	2010	An important finding is that two key variables linking a person"s health perceptions regarding tap water quality are significant factors leading to the choice of either filtered tap water or bottled water over tap water.	Water	182-187	nuclear RNA export factor 1	Homo sapiens	178-181
20705979-8	2010	An important finding is that two key variables linking a person"s health perceptions regarding tap water quality are significant factors leading to the choice of either filtered tap water or bottled water over tap water.	Water	182-187	nuclear RNA export factor 1	Homo sapiens	95-98
20705979-8	2010	An important finding is that two key variables linking a person"s health perceptions regarding tap water quality are significant factors leading to the choice of either filtered tap water or bottled water over tap water.	Water	182-187	nuclear RNA export factor 1	Homo sapiens	178-181
20692763-6	2010	Since titanium dioxide particles in tap water spontaneously sedimented on standing after the photocatalytic treatment, the combined treatment can be operated by integrating with the titanium dioxide separation and reuse.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
20705979-8	2010	An important finding is that two key variables linking a person"s health perceptions regarding tap water quality are significant factors leading to the choice of either filtered tap water or bottled water over tap water.	Water	182-187	nuclear RNA export factor 1	Homo sapiens	178-181
4035342-7	1985	The conclusion is consistent with an upper guide value of 0.05 mgl-1 for the concentration of lead in drinking water.	Water	111-116	LLGL scribble cell polarity complex component 1	Homo sapiens	63-68
20923173-9	2010	The second binding motif, WT2, is identical with the exception of the zinc-bound D297beta being replaced by a water molecule in the Mg2+ coordination complex.	Water	110-115	multiple tumor-associated chromosome region 1	Homo sapiens	26-29
2984992-0	1985	Modified membrane-filter procedure for concentration of enteroviruses from tap water.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
20736165-1	2010	The small intestinal BB Na(+)/H(+) antiporter NHE3 accounts for the majority of intestinal sodium and water absorption.	Water	102-107	solute carrier family 9 member A3	Homo sapiens	46-50
21169508-0	2010	The Arabidopsis GTL1 transcription factor regulates water use efficiency and drought tolerance by modulating stomatal density via transrepression of SDD1.	Water	52-57	GT-2-like 1	Arabidopsis thaliana	16-20
21169508-0	2010	The Arabidopsis GTL1 transcription factor regulates water use efficiency and drought tolerance by modulating stomatal density via transrepression of SDD1.	Water	52-57	Subtilase family protein	Arabidopsis thaliana	149-153
21169508-3	2010	Arabidopsis thaliana GT-2 LIKE 1 (GTL1) loss-of-function mutations result in increased water deficit tolerance and higher integrated WUE by reducing daytime transpiration without a demonstrable reduction in biomass accumulation.	Water	87-92	GT-2-like 1	Arabidopsis thaliana	21-32
21169508-3	2010	Arabidopsis thaliana GT-2 LIKE 1 (GTL1) loss-of-function mutations result in increased water deficit tolerance and higher integrated WUE by reducing daytime transpiration without a demonstrable reduction in biomass accumulation.	Water	87-92	GT-2-like 1	Arabidopsis thaliana	34-38
2984992-2	1985	Viruses in tap water at pH 3.5 were first adsorbed to 10-in.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
20851747-0	2010	Hypoalgesia in mice lacking aquaporin-4 water channels.	Water	40-45	aquaporin 4	Mus musculus	28-39
20844266-5	2010	Water deprivation increased c-Fos staining in the lamina terminalis.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	28-33
2984992-9	1985	45% of several types of enteroviruses added to 114 liters of tap water could be recovered in the final 16-ml sample.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
6569854-2	1984	The same organism was recovered from the dialysate produced by the machine and from its tap water supply.	Water	92-97	nuclear RNA export factor 1	Homo sapiens	88-91
20843510-3	2010	The 2008 NTP chronic bioassay of sodium dichromate dihydrate in drinking water found clear evidence of carcinogenicity in rodents and allows a generalizable estimate of the human ingestion cancer potency of Cr(6+).	Water	73-78	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	207-213
21250464-5	2010	Composting leachate processing with biological stabilization and dilution showed a fertilizer efficiency, and dry weight of impatiens irrigated with composting leachate was 1.46-2.49 times of tap water irrigation.	Water	196-201	nuclear RNA export factor 1	Homo sapiens	192-195
20875670-4	2010	A single-pass flow-through experiment was run in a 100-liter column: bioremediation for 1year followed by infiltration of tap water (2.5years) saturated with oxygen, sufficient to oxidize the precipitated uraninite in two months.	Water	126-131	nuclear RNA export factor 1	Homo sapiens	122-125
20949964-7	2010	The rotational barriers to cis-to-trans isomerization are estimated to be 19.73 kcal/mol for the Ala-Pro tripeptide and 16.64 kcal/mol for the Aib-Pro tripeptide in water, which indicates that the rotational barrier becomes lower by ~3 kcal/mol for the Aib-Pro peptide bond.	Water	165-170	ANIB1	Homo sapiens	143-146
20949964-7	2010	The rotational barriers to cis-to-trans isomerization are estimated to be 19.73 kcal/mol for the Ala-Pro tripeptide and 16.64 kcal/mol for the Aib-Pro tripeptide in water, which indicates that the rotational barrier becomes lower by ~3 kcal/mol for the Aib-Pro peptide bond.	Water	165-170	ANIB1	Homo sapiens	253-256
6522243-5	1984	As the prostaglandin analogue effectively blocked the antidiuretic effect of the AVP-administration it appears that 9-methylene-PGE2 may play a future role as a diuretic agent, especially in conditions characterized by water retention and dilutional hyponatremia such as SIADH.	Water	219-224	vasopressin-neurophysin 2-copeptin	Ovis aries	81-84
20739606-1	2010	The mammalian aquaporins AQP1, AQP4, and AQP5 have been shown to function not only as water channels but also as gas channels.	Water	86-91	aquaporin 4	Homo sapiens	31-35
20739606-9	2010	Xenopus oocytes expressing aqp1a have a channel-dependent (*) osmotic water permeability (P(f)(*)) that is indistinguishable from that of human AQP1.	Water	70-75	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	27-32
20702073-8	2010	The value of lnk elevates with the increase in mobile phase NaCl concentration i.e. Deltalnk/Deltac(NaCl) depends on the number of water molecules not stabilised by hydrogen bonds in bile acid hydration sheath.	Water	131-136	SH2B adaptor protein 3	Homo sapiens	13-16
20938542-5	2010	Different processes control the water chemistry along the course of the Sava"s drainage-the upper reaches are largely regulated by contributions from carbonate mineral weathering, the middle reaches are influenced by agricultural activity and biological processes related to eutrophication, while the lower reaches tend to have more pronounced parameters related to the industrial processing along with leakages from municipal sanitary systems of these higher population density areas.	Water	32-37	T-box transcription factor T	Homo sapiens	72-76
20925342-1	2010	The dehydratase (DH) domain of module 4 of the 6-deoxyerythronolide B synthase (DEBS) has been shown to catalyze an exclusive syn elimination/syn addition of water.	Water	158-163	synemin	Homo sapiens	70-73
20925342-1	2010	The dehydratase (DH) domain of module 4 of the 6-deoxyerythronolide B synthase (DEBS) has been shown to catalyze an exclusive syn elimination/syn addition of water.	Water	158-163	synemin	Homo sapiens	126-129
20969805-3	2010	Water channel proteins, known as aquaporins (AQPs), notably AQP-1 and AQP-4, appears to be involved in the pathophysiology of several neurological diseases.	Water	0-5	aquaporin 4	Homo sapiens	70-75
20591562-5	2010	The emergency treatment process removed the odor from the tap water and solved the crisis successfully in several days.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
20836703-2	2010	The strain, isolated from a water supply epidemiologically linked to the outbreak, was virulent to mice, and it has previously been identified as BrI.	Water	28-33	integral membrane protein 2B	Mus musculus	146-149
20728226-0	2010	Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis.	Water	12-17	aquaporin 4	Homo sapiens	0-11
20728226-2	2010	A significant proportion of NMO patients are seropositive for NMO-IgG, an autoantibody targeting aquaporin-4 (AQP4) water channel.	Water	116-121	aquaporin 4	Homo sapiens	97-108
20728226-2	2010	A significant proportion of NMO patients are seropositive for NMO-IgG, an autoantibody targeting aquaporin-4 (AQP4) water channel.	Water	116-121	aquaporin 4	Homo sapiens	110-114
20544823-6	2010	The data suggest that water flux through AQP4 is involved in the rapid volume regulation of retinal glial (Muller) cells in response to osmotic stress and that deletion of AQP4 results in an inflammatory response of the retinal tissue.	Water	22-27	aquaporin 4	Mus musculus	41-45
20544823-6	2010	The data suggest that water flux through AQP4 is involved in the rapid volume regulation of retinal glial (Muller) cells in response to osmotic stress and that deletion of AQP4 results in an inflammatory response of the retinal tissue.	Water	22-27	aquaporin 4	Mus musculus	172-176
20709083-0	2010	Influence of the cytoplasmic domains of aquaporin-4 on water conduction and array formation.	Water	55-60	aquaporin 4	Homo sapiens	40-51
20709083-1	2010	Phosphorylation of Ser180 in cytoplasmic loop D has been shown to reduce the water permeability of aquaporin (AQP) 4, the predominant water channel in the brain.	Water	77-82	aquaporin 4	Homo sapiens	110-116
20709083-1	2010	Phosphorylation of Ser180 in cytoplasmic loop D has been shown to reduce the water permeability of aquaporin (AQP) 4, the predominant water channel in the brain.	Water	134-139	aquaporin 4	Homo sapiens	110-116
20603675-8	2010	The transfection ability of ABP-SS/pGL-3 complexes formed in deionized water was much weaker than that formed in 150 mM NaCl solution.	Water	71-76	succinate dehydrogenase complex subunit C	Homo sapiens	35-40
19942644-0	2010	Nano-porous pottery using calcined waste sediment from tap water production as an additive.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
20580685-2	2010	Melittin and apamin were extracted with pure water from CBVLP samples followed by HPLC-DAD-MS/MS analysis.	Water	45-50	melittin	Apis mellifera	0-8
20623055-3	2010	In the presence of water, the hydrogen migration occurs via a six-membered ring transition state and the corresponding energy barrier decreases dramatically, and therefore the RDS is the C-C bond formation step.	Water	19-24	peripherin 2	Homo sapiens	176-179
20652203-7	2010	Both macrocyclic compounds PdL(2).6H(2)O and PdL(3).5H(2)O are characterized by lamellar crystal structures consisting of interleaved layers formed by macrocyclic units and by water molecules with similar metal complex layers and different 2D water sheets.	Water	176-181	programmed cell death 1 ligand 2	Homo sapiens	27-33
20493244-0	2010	Effect of hot-water extraction on alkaline pulping of bagasse.	Water	14-19	alcohol dehydrogenase iron containing 1	Homo sapiens	10-13
20493244-1	2010	The effect of hot-water extraction on alkaline pulping was investigated.	Water	18-23	alcohol dehydrogenase iron containing 1	Homo sapiens	14-17
20493244-8	2010	Hot-water extraction resulted in a significant decrease in bleaching chemical consumption and the formation of chlorinated organics.	Water	4-9	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
20713081-1	2010	Chemical and thermal cross-linking of collagen soluble in acetic acid and elastin hydrolysates soluble in water have been studied.	Water	106-111	elastin	Homo sapiens	74-81
20864897-1	2010	Excessively hot tap water results in an estimated 1500 hospital admissions and up to 50 deaths in the United States every year.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
20864897-4	2010	Model building and plumbing codes related to tap water temperature regulation and their subsequent adoption by state legislatures vary widely across the United States.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
20864897-7	2010	A broader and more uniform application of codes for regulating tap water temperature in both institutional and residential settings can be achieved through input from affected users, government agencies, legislators, advocacy organizations, and the general public.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
20685122-1	2010	Aquaporin-4 (AQP4) is the most important member of the aquaporin (AQP) family in the central nervous system and has a key role in maintaining water and ion homeostasis.	Water	142-147	aquaporin 4	Homo sapiens	0-11
20685122-1	2010	Aquaporin-4 (AQP4) is the most important member of the aquaporin (AQP) family in the central nervous system and has a key role in maintaining water and ion homeostasis.	Water	142-147	aquaporin 4	Homo sapiens	13-17
20848345-10	2010	The altered centrally applied AngII response in SHR associated with increased hypothalamic JAK-2/SOCS-3 expression may suggest that abnormal regulation of the central angiotensin pathways may contribute to dysfunction of water-electrolyte homeostasis in SHR.	Water	221-226	Janus kinase 2	Rattus norvegicus	91-96
20380861-2	2010	AQP4, the predominant brain water channel, is expressed in astrocyte endfeet facing brain capillaries, perisynaptic spaces, and nodes of Ranvier.	Water	28-33	aquaporin 4	Homo sapiens	0-4
21031617-4	2010	In addition, rats gavaged with CH-GTE and Se-GTE showed a 17.2% and 21.3% reduction in the activity of the bacterial enzyme beta-glucuronidase, respectively, when compared with the rats gavaged with water only.	Water	199-204	glucuronidase, beta	Rattus norvegicus	124-142
21384572-0	2010	[Spa-based water procedures and complications in the course of their performance].	Water	11-16	surfactant protein A2	Homo sapiens	1-4
21588864-1	2010	In the title complex, [Ca(C(10)H(6)NO(2))(2)(H(2)O)(2)](n), the Ca(II) ion is eight-coordinated by six carboxyl-ate O atoms from four separate quinoline-3-carboxyl-ate ligands, two of which are bidentate chelate and two bridging, and two water mol-ecules in a distorted square-anti-prismatic geometry.	Water	45-50	carbonic anhydrase 2	Homo sapiens	64-70
21588864-1	2010	In the title complex, [Ca(C(10)H(6)NO(2))(2)(H(2)O)(2)](n), the Ca(II) ion is eight-coordinated by six carboxyl-ate O atoms from four separate quinoline-3-carboxyl-ate ligands, two of which are bidentate chelate and two bridging, and two water mol-ecules in a distorted square-anti-prismatic geometry.	Water	238-243	carbonic anhydrase 2	Homo sapiens	64-70
21060670-6	2010	The patients were all contact lens wearers who had washed their lens storage cases with tap water.	Water	92-97	nuclear RNA export factor 1	Homo sapiens	88-91
20850122-3	2010	The limits of quantifications (LOQs) were lowest in tap water, where they ranged from 1.1 to 13.3 ng L(-1), and highest in raw wastewater (10.5-84.9 ng L(-1)).	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
20815365-1	2010	Zinc binding to P113 (or demegen), a 12 amino acid (AKRHHGYKRKFH-NH(2)) fragment of histatin 5, was investigated by means of NMR and CD techniques, yielding delineation of the metal binding site and the 3D structure of the complex in water and in DMSO as well.	Water	234-239	signal transducer and activator of transcription 2	Homo sapiens	16-20
20735717-7	2010	RESULTS: The vast majority of participants (n = 46) avoided drinking unfiltered tap water based on perceptions that it had poor taste, smell, and color, bolstered by a historically justified and collectively transmitted belief that the public water supply is unsafe.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
20609528-5	2010	In addition, water holding capacity of the breast was enhanced by the 1.0% dietary MGL treatment and was accompanied by a slight antimicrobial activity (1 decimal reduction) during storage.	Water	13-18	C-type lectin domain containing 10A	Homo sapiens	83-86
20701310-4	2010	A new computational method for separating solvent, protein, and fluorophore contributions to TDSS is applied to 100 nonequilibrium trajectories for GB1 in TIP3P water.	Water	161-166	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	148-151
20701302-0	2010	Preparation of surface imprinting polymer capped Mn-doped ZnS quantum dots and their application for chemiluminescence detection of 4-nitrophenol in tap water.	Water	153-158	nuclear RNA export factor 1	Homo sapiens	149-152
20594577-2	2010	In this study, its concentrations in the STP effluents in 68 countries/regions are predicted with a model based on the sale volume, the water consumption, the disposal rate, the excretion rate, and the removal efficiency by the sewage system.	Water	136-141	thyroid hormone receptor interactor 10	Homo sapiens	41-44
19680752-4	2010	TFP of postchlorinated treated water were investigated at six water treatment plants (WTPs) in Delhi City (India).	Water	31-36	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	0-3
20553906-10	2010	EGCG significantly inhibited telomere attrition, TRF(2) loss and p53, p21 upregulation induced by H(2)O(2).	Water	98-103	KRAS proto-oncogene, GTPase	Rattus norvegicus	70-73
20571963-6	2010	SOX deficiency was established by feeding rats a low molybdenum diet and adding to their drinking water 200 ppm tungsten (W).	Water	98-103	sulfite oxidase	Rattus norvegicus	0-3
20824120-8	2010	Co-localization of AQP4 and Kir4.1 may indicate that water flux mediated by AQP4 is associated with K(+) siphoning.	Water	53-58	aquaporin 4	Mus musculus	19-23
20824120-8	2010	Co-localization of AQP4 and Kir4.1 may indicate that water flux mediated by AQP4 is associated with K(+) siphoning.	Water	53-58	aquaporin 4	Mus musculus	76-80
20638362-5	2010	In the present study, we observed that the mouse embryonic fibroblasts (MEFs) from CD38(-/-) mice were significantly resistant to oxidative stress such as H(2)O(2) injury and hypoxia/reoxygenation compared with wild type MEFs (WT MEFs).	Water	155-160	CD38 antigen	Mus musculus	83-87
20663510-7	2010	Under optimum conditions, the range of enrichment factors and extraction recoveries of tap water samples are ranging 372-1308 and 87-105%, respectively.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
20663510-9	2010	The relative standard deviations (RSD) for 0.01microgL(-1) of PAHs in tap water were in the range of 5.1-10.0%.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
20809947-11	2010	Of the multiple functions of FOXI1, its role in kidney-mediated water-electrolyte homeostasis is the most obvious candidate for explaining a climate-related adaptation.	Water	64-69	forkhead box I1	Homo sapiens	29-34
6441894-1	1984	Administration of cholecystokinin (CCK) (0.2 - 0.6 micrograms in a volume of 2 microliter) into the lateral cerebral ventricle caused a decrease in intake of food but a relative increase in intake of water (or water-to-food ratio) in rats.	Water	210-215	cholecystokinin	Rattus norvegicus	18-33
6441894-1	1984	Administration of cholecystokinin (CCK) (0.2 - 0.6 micrograms in a volume of 2 microliter) into the lateral cerebral ventricle caused a decrease in intake of food but a relative increase in intake of water (or water-to-food ratio) in rats.	Water	210-215	cholecystokinin	Rattus norvegicus	35-38
20844304-2	2010	The NMO-immunoglobulin (Ig) G auto-antibody (Ab), which binds to the aquaporin-4 (AQP4) water channel protein, is a marker for NMO.	Water	88-93	aquaporin 4	Homo sapiens	69-80
20844304-2	2010	The NMO-immunoglobulin (Ig) G auto-antibody (Ab), which binds to the aquaporin-4 (AQP4) water channel protein, is a marker for NMO.	Water	88-93	aquaporin 4	Homo sapiens	82-86
6441894-3	1984	Administration of CCK into the lateral hypothalamus, but not the anterior hypothalamus or ventromedial hypothalamus, caused decreased intake of food and a relative increased intake of water.	Water	184-189	cholecystokinin	Rattus norvegicus	18-21
6745606-2	1984	The aim of the present study was to investigate whether motilin may have an effect on intestinal water and ion transport.	Water	97-102	motilin	Homo sapiens	56-63
6745606-5	1984	Motilin infusion significantly reduced absorption of water, sodium, potassium, and chloride when a plasmalike electrolyte solution was perfused.	Water	53-58	motilin	Homo sapiens	0-7
19995560-1	2010	in domestic tap water in houses of contact lens wearers in the metropolitan area of Mexico City.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
6745606-6	1984	During perfusion with a bicarbonate-free salt solution, motilin significantly enhanced secretion of water, potassium, and chloride.	Water	100-105	motilin	Homo sapiens	56-63
19995560-9	2010	Most Acanthamoeba isolates were non-pathogenic, however, their presence in tap water is a potential hazard since some species can cause Acanthamoeba keratitis and granulomatous amoebic encephalitis.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
6207427-1	1984	Covalent coupling of glutamyl-glutamic acid to the amino group of ether-phosphatidylethanolamine (EPE) yields an acidic "peptidophospholipid" (Glu2-EPE) which is water-soluble above pH 7.0 and stable to phospholipase A.	Water	162-167	Post-stress glucose level	Sus scrofa	143-147
20712628-0	2010	Kinetic analyses of plant water relocation using deuterium as tracer - reduced water flux of Arabidopsis pip2 aquaporin knockout mutants.	Water	26-31	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	105-109
20712628-7	2010	The deuterium tracer method was employed to assess water relocation in Arabidopsis pip2;1 and pip2;2 aquaporin knockout plants.	Water	51-56	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	83-89
20712628-7	2010	The deuterium tracer method was employed to assess water relocation in Arabidopsis pip2;1 and pip2;2 aquaporin knockout plants.	Water	51-56	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	83-87
6207427-6	1984	All derivatives of Glu2-EPE are water-soluble at physiological pH and readily adsorb to cell surfaces from aq.	Water	32-37	Post-stress glucose level	Sus scrofa	19-23
6095374-6	1984	All 6-hydroxydopamine-injected animals reduced their food and water intake in response to the cholecystokinin challenge as did intact controls.	Water	62-67	cholecystokinin	Rattus norvegicus	94-109
20525898-8	2010	On long-term (16 h) exposure to H(2)O(2), signs of necrotic cell death became apparent in LC3-positive cells, which could be prevented by ZVAD-fmk.	Water	32-37	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	90-93
6095374-7	1984	These results indicate that while the changes in food and water intake produced by the central injection of cholecystokinin, bombesin or gastrin may involve central catecholamine systems, those occurring after its systemic administration do not.	Water	58-63	cholecystokinin	Rattus norvegicus	108-123
20596557-1	2010	Construction of a 3-D supramolecular network from [Ln(cpb)(3)(H(2)O)(2)] (Ln = Nd, Tb; Hcpb = 1-(4-cyanophenyl)-1,3-butanedione) by sequential displacement of a coordinated water by DMF, dimerisation by reciprocal hydrogen bonding in solution and pi-pi stacking and interdigitation of nitriles has been monitored by in situ fourier transform infrared spectroscopy.	Water	173-178	carboxypeptidase B1	Homo sapiens	54-57
6095374-7	1984	These results indicate that while the changes in food and water intake produced by the central injection of cholecystokinin, bombesin or gastrin may involve central catecholamine systems, those occurring after its systemic administration do not.	Water	58-63	gastrin	Rattus norvegicus	137-144
18963639-5	1984	The proposed method has been tested in the determination of lead in tap water.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
20493929-5	2010	Moreover, model mice had decreased expressions of glutamate transporter 1, glutamate/aspartate transporter, glutamine synthetase and connexin 43, but an increased expression of water channel protein aquaporin-4 in the hippocampus as revealed by immunohistochemistry and immunoblotting analysis.	Water	177-182	aquaporin 4	Mus musculus	199-210
6487007-2	1984	During a sailing maneuvre the mast of the boat was brought into contact with a high-voltage transmission line; the metal parts of the boat caused a ground connection into the water.	Water	175-180	ataxin 1 like	Homo sapiens	42-46
20578724-1	2010	The catalysis of CO(2) hydration by human carbonic anhydrase II (HCA II) is limited in maximal velocity by proton transfer from a zinc-bound water molecule to the proton shuttle His64.	Water	141-146	carbonic anhydrase 2	Homo sapiens	42-63
6487007-2	1984	During a sailing maneuvre the mast of the boat was brought into contact with a high-voltage transmission line; the metal parts of the boat caused a ground connection into the water.	Water	175-180	ataxin 1 like	Homo sapiens	134-138
20362052-6	2010	Podocytes treated for 20min with H(2)O(2) (10(-4)M), which mimics reactive oxygen species generation by cells challenged by hyperglycemic or enhanced Pgc conditions, significantly increased the levels of active p38 MAPK, AKT, JNK and ERK1/2.	Water	33-38	mitogen-activated protein kinase 8	Mus musculus	226-229
6725087-1	1984	To find whether sweat rate (SR) and forearm skin blood flow ( SkBF ) were reflexly affected by skin temperature (Tsk) we used water-perfused suits to rapidly elevate Tsk during exercise.	Water	126-131	tsukushi, small leucine rich proteoglycan	Homo sapiens	113-116
20554274-9	2010	Brominated THM predominated in the tap water (84% of total THM) and chloroform predominated in the swimming pool (84% of total THM).	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
6725087-1	1984	To find whether sweat rate (SR) and forearm skin blood flow ( SkBF ) were reflexly affected by skin temperature (Tsk) we used water-perfused suits to rapidly elevate Tsk during exercise.	Water	126-131	tsukushi, small leucine rich proteoglycan	Homo sapiens	166-169
21090297-5	2010	With the UV pretreatment process, after 3 h UV irradiation, 52% of soluble organic matter could be removed by pretreatment, and the content of TOC and the turbidity of the filtrated water were 2.0 mg/L and 1.0 NTU, respectively.	Water	182-187	rhomboid 5 homolog 2	Homo sapiens	143-146
6726645-2	1984	Two of the derivatives (sufficiently water-soluble for the assay) were found to inhibit glyoxalase I to a greater extent than did S-methylglutathione.	Water	37-42	glyoxalase 1	Mus musculus	88-100
21090297-7	2010	The optimum in combined pretreatment process was that the concentration of ozone dose (O3/C) was 1.0 mg/mg, the time of UV irradiation was 1 h, the TOC of the filtrated water was 2.	Water	169-174	rhomboid 5 homolog 2	Homo sapiens	148-151
20405312-2	2010	Polyamine oxidase (PAO), a FAD-containing enzyme is involved in the biodegradation of Sp and Spd, catalyzing the oxidative deamination of Sp and Spd, resulting in production of ammonia (NH(3)), corresponding amino aldehydes and H(2)O(2).	Water	228-233	polyamine oxidase	Homo sapiens	0-17
6322223-4	1984	It is assumed that the remainder of water in the tissue has a relaxation rate that is independent of frequency, as is characteristic of bulk tap water.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	141-144
20405312-2	2010	Polyamine oxidase (PAO), a FAD-containing enzyme is involved in the biodegradation of Sp and Spd, catalyzing the oxidative deamination of Sp and Spd, resulting in production of ammonia (NH(3)), corresponding amino aldehydes and H(2)O(2).	Water	228-233	polyamine oxidase	Homo sapiens	19-22
19747527-13	2010	This differential localization of AQP5 and AQP4 in the apical and basolateral membranes of the same epithelial cell type suggests a direct aquaporin-mediated transcellular water shunt between the perilymph and endolymph in the OSCs of the cochlear lateral wall.	Water	172-177	aquaporin 4	Homo sapiens	43-47
6322223-4	1984	It is assumed that the remainder of water in the tissue has a relaxation rate that is independent of frequency, as is characteristic of bulk tap water.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
6144179-5	1984	Both the gastrointestinal peptides vasoactive intestinal peptide (VIP) and secretin reduce the net water absorption in the gallbladder.	Water	99-104	secretin	Homo sapiens	75-83
19761816-0	2010	Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion.	Water	0-5	aquaporin 4	Homo sapiens	27-38
19761816-5	2010	Using D54MG glioma cells stably transfected with either AQP1 or AQP4, we show that PKC activity regulates water permeability through phosphorylation of AQP4.	Water	106-111	aquaporin 4	Homo sapiens	64-68
6363076-8	1984	It is concluded on such grounds that the much debated pH dependence of coenzyme binding to liver alcohol dehydrogenase must derive from ionization of zinc-bound water.	Water	161-166	aldo-keto reductase family 1 member A1	Homo sapiens	97-118
19761816-5	2010	Using D54MG glioma cells stably transfected with either AQP1 or AQP4, we show that PKC activity regulates water permeability through phosphorylation of AQP4.	Water	106-111	aquaporin 4	Homo sapiens	152-156
19850108-3	2010	In astrocytes, AQP4 is mainly involved in water and ionic homeostasis.	Water	42-47	aquaporin 4	Homo sapiens	15-19
19850109-0	2010	Regulation of water permeability through aquaporin-4.	Water	14-19	aquaporin 4	Homo sapiens	41-52
6199041-8	1984	Replacement of 120 mM KCl with either 120 mM choline chloride, 240 mM sucrose, or H2O reduced maximal calcium sequestration by LSR, but had less effect on LSR calcium release rate constants.	Water	82-85	LOW QUALITY PROTEIN: lipolysis-stimulated lipoprotein receptor	Oryctolagus cuniculus	127-130
19850109-2	2010	AQP4 is a critical component of an integrated water and potassium homeostasis.	Water	46-51	aquaporin 4	Homo sapiens	0-4
6087436-2	1984	Tap water contained high amounts of lead and biopsy confirmed the intoxication.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
20628603-8	2010	Flies with reduced DTK or sNPF levels in these cells displayed decreased survival time at desiccation and starvation, as well as increased water loss at desiccation.	Water	139-144	short neuropeptide F precursor	Drosophila melanogaster	26-30
20532539-2	2010	In most patients affected by this disease, injury to astrocytes is initiated by the action of autoantibodies targeting aquaporin 4 (AQP-4), a water channel on astrocytes.	Water	142-147	aquaporin 4	Homo sapiens	119-130
20532539-2	2010	In most patients affected by this disease, injury to astrocytes is initiated by the action of autoantibodies targeting aquaporin 4 (AQP-4), a water channel on astrocytes.	Water	142-147	aquaporin 4	Homo sapiens	132-137
20434248-0	2010	Determination of four fluoroquinolone antibiotics in tap water in Guangzhou and Macao.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
6141212-3	1983	Gel filtration (Sephadex G25) was more effective than dialysis against water in the removal of inhibitors of N-acetyl-beta-D-glucosaminidase and beta-glucuronidase.	Water	71-76	glucuronidase, beta	Rattus norvegicus	145-163
20434248-1	2010	Four fluoroquinolone antibiotics (norfloxacin, ciprofloxacin, lomefloxacin, and enrofloxacin) in tap water in Guangzhou and Macao were analyzed using high performance liquid chromatography fluorescence detection.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
20434248-3	2010	The fluoroquinolone antibiotics pollution in tap water widely distributes in Guangzhou and Macao.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
20434248-5	2010	Our result indicates that the antibiotic concentration in tap water in Guangzhou tends to obviously reduce at the beginning of rainy season, even decreases below the limit of quantification immediately.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
20300855-2	2010	In this paper, a hydrophobic photodynamic therapy drug, hypocrellin A (HA), was successfully encapsulated in water-soluble amorphous silica nanocage (HANC) by an improved sol-gel method.	Water	109-114	long intergenic non-protein coding RNA 184	Homo sapiens	150-154
6604062-6	1983	The Michaelis constant for methyl-AIB uptake was 540 microM; the maximal velocity of uptake was 28 mumol/L cell water/min, and the diffusion coefficient was .004 min-1.	Water	112-117	ANIB1	Homo sapiens	34-37
20452023-8	2010	Estimated daily intakes of 4-NP, BPA and TCS for infants were 705, 1340 and 5 ng/day, respectively, by drinking 1L of tap water from a baby bottle at 40 degrees C. This study showed that the exposure to the three compounds from drinking water is unlikely to pose a health risk.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
20444965-2	2010	We describe a pseudo-outbreak in which multiple strains that were associated with moistening of culturette swabs with tap water were isolated from a single clinic before collecting the patient specimen.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
6314120-1	1983	The secondary structure of histones H2B and H3 from calf thymus has been quantitatively studied in heavy water solutions in a wide range of histone concentrations, pD, and concentrations of sodium chloride by an infrared spectroscopy method.	Water	105-110	histone H2B type 2-E	Bos taurus	36-46
20456049-8	2010	Furthermore, lsd1-3 plants accumulated higher concentrations of H(2)O(2) and total glutathione under cold conditions than wild-type plants.	Water	64-69	LSD1 zinc finger family protein	Arabidopsis thaliana	13-17
20471413-6	2010	It was found out that combination of the protective effect of the polyelectrolyte membrane in SIF associated with the hydrophobicity of PCL grafts allowed to release a poorly water-soluble drug, in a controlled manner, for 7h, along a simulated gastro-intestinal tract.	Water	175-180	PHD finger protein 1	Homo sapiens	136-139
20451955-1	2010	INTRODUCTION: Salvianolic acid A (SAA), the water-soluble phenolic acids in Salvia miltiorrhiza, has shown the most potent bioactivities, including protection against cerebral lesion, defense from oxidative damage and improvement of remembrance.	Water	44-49	serum amyloid A1 cluster	Homo sapiens	34-37
6637279-5	1983	The NAG vibrios isolated from patients, carriers and the sources of water supply nearest to them belonged to the same phagovars.	Water	68-73	NBAS subunit of NRZ tethering complex	Homo sapiens	4-7
20509693-3	2010	beta-Gal catalyzes the hydrolysis of lactose, and the produced glucose is catalytically oxidized to gluconic acid and H(2)O(2), which is reduced in the presence of HRP.	Water	118-123	beta-galactosidase	Theobroma cacao	0-8
21125904-1	2010	In this paper, a simple method was presented to measure the concentration change in the Cr(VI)-contained waste water during treatment by nanoparticles, based on its optical absorption spectral evolution which exhibits a good linear relationship between the absorbance of the peak at 348 nm and Cr6+ ion concentration.	Water	111-116	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	294-297
21125904-2	2010	The iron and Fe/Pd bimetal nanoparticles were prepared and used for removal of Cr6+ in waste water.	Water	93-98	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	79-82
6311332-1	1983	The water-soluble inhibitory benzodiazepine, midazolam, was applied in low nanomolar concentrations to CA1 hippocampal neurons in vitro, recorded intracellularly.	Water	4-9	carbonic anhydrase 1	Homo sapiens	103-106
20673327-2	2010	We had previously shown that doxycycline administered for 3 months at 40 mg/Kg/ml in the drinking water, was capable of removing TTR amyloid deposits present in stomachs of old TTR-V30M transgenic mice; the removal was accompanied by a decrease in extracellular matrix remodeling proteins that accompany fibrillar deposition, but not of non-fibrillar TTR deposition and/or markers associated with pre-fibrillar deposits.	Water	98-103	transthyretin	Mus musculus	129-132
20428523-0	2010	Ruthenium/TFA-catalyzed regioselective C-3-alkylation of indoles with terminal alkynes in water: efficient and unprecedented access to 3-(1-methylalkyl)-1H-indoles.	Water	90-95	complement C3	Homo sapiens	39-42
19699271-1	2010	Neuromyelitis optica (NMO) is the first inflammatory autoimmune demyelinating disease of the CNS for which a specific tissue target molecule has been identified--the astrocytic water channel aquaporin-4 (AQP4).	Water	177-182	aquaporin 4	Homo sapiens	191-202
6412968-0	1983	[Various renal reactions to immersion in tap water and carbonic water].	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
19699271-1	2010	Neuromyelitis optica (NMO) is the first inflammatory autoimmune demyelinating disease of the CNS for which a specific tissue target molecule has been identified--the astrocytic water channel aquaporin-4 (AQP4).	Water	177-182	aquaporin 4	Homo sapiens	204-208
19699271-9	2010	In vitro studies demonstrate that binding of NMO-IgG to astrocytic AQP4 initiates multiple potentially neuropathogenic mechanisms: complement activation, AQP4 and EAAT2 downregulation with disruption of water and glutamate homeostasis, enhanced blood-brain barrier permeability, plasma protein and granulocyte influx, and antibody-dependent cell-mediated cytotoxicity.	Water	203-208	aquaporin 4	Homo sapiens	67-71
20524635-6	2010	Our work indicates that water is a very important component of the binding site of the beta(2)AR receptor.	Water	24-29	adrenoceptor beta 2	Homo sapiens	87-96
20395291-2	2010	Molecular dynamics simulations showed that, although the fewer water molecules in rhodopsin were relatively movable, the hydrogen bond network of the beta2-adrenergic receptor was fully loaded with water molecules that were surprisingly immobilized between the two rotamer switches, both apparently being in their closed conformation.	Water	198-203	adrenoceptor beta 2	Homo sapiens	150-175
20395291-5	2010	Mutational analysis of the beta2-adrenergic receptor demonstrated that the highly conserved polar residues of the hydrogen bond network were all important for receptor signaling but served different functions, some dampening constitutive activity (AsnI:18, AspII:10, and AsnVII:13), whereas others (AsnVII:12 and AsnVII:16) located one helical turn apart and sharing a water molecule were shown to be essential for agonist-induced signaling.	Water	369-374	adrenoceptor beta 2	Homo sapiens	27-52
20524635-7	2010	We found that the higher stereoselectivity of the srrr-configuration is due to interactions with water molecules, which extensively hydrate the binding site of beta(2)AR.	Water	97-102	adrenoceptor beta 2	Homo sapiens	160-169
6309878-4	1983	The adsorbed viruses from both tap water and secondary sewage were most efficiently eluted with 4% beef extract - 0.5 M NaC1, pH 9.5.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
20524635-8	2010	By lowering the energy of binding, water enhanced the affinity of the srrr-form to beta(2)AR.	Water	35-40	adrenoceptor beta 2	Homo sapiens	83-92
20533842-0	2010	Complex formation of small molecules during isolation in low temperature matrices: water dimers in p-H2 and Ne matrices.	Water	83-88	polyhomeotic homolog 2	Homo sapiens	99-103
20533842-1	2010	The concentrations of water dimer are compared in Ne and p-H(2) matrices at low temperatures, using infrared spectroscopy.	Water	22-27	polyhomeotic homolog 2	Homo sapiens	57-63
20441944-8	2010	Validation of the analytical system has been performed by the successful determination of free chlorine in tap water and swimming pools water samples.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
20533842-4	2010	In p-H(2), the dimer concentration is only slightly higher than expected for a random distribution of water in the matrix.	Water	102-107	polyhomeotic homolog 2	Homo sapiens	3-9
6309878-6	1983	of tap water ranged between 32 and 98%, 67 and 100% and 69 and 100%, respectively.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
20446703-0	2010	Stabilizing of a globular protein by a highly complex water network: a molecular dynamics simulation study on factor Xa.	Water	54-59	coagulation factor X	Homo sapiens	110-119
6851157-0	1983	Volatile halocarbons in tap water as a problem in haemodialysis therapy.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
20446703-2	2010	Here, we present molecular dynamics studies on factor Xa (fXa) to investigate the effect of water molecules in this serine protease.	Water	92-97	coagulation factor X	Homo sapiens	47-56
20446703-2	2010	Here, we present molecular dynamics studies on factor Xa (fXa) to investigate the effect of water molecules in this serine protease.	Water	92-97	coagulation factor X	Homo sapiens	58-61
20446703-5	2010	Simulations of well-resolved fXa X-ray structures with different sets of water molecules show the importance of a well-determined water set for the simulation.	Water	73-78	coagulation factor X	Homo sapiens	29-32
20446703-5	2010	Simulations of well-resolved fXa X-ray structures with different sets of water molecules show the importance of a well-determined water set for the simulation.	Water	130-135	coagulation factor X	Homo sapiens	29-32
20446703-6	2010	We discuss implications of different water sets on the structure and dynamics of fXa.	Water	37-42	coagulation factor X	Homo sapiens	81-84
20363475-10	2010	In addition, the affinity of recombinant AnxA6-1 tryptophan mutant (W343F) to the air/water interface and to lipid monolayers was tested.	Water	86-91	annexin A6	Homo sapiens	41-46
6851157-1	1983	The concentrations of volatile halocarbons in the tap water of Turku and of Turku University Central Hospital are quite high and are reduced but not eliminated during water treatment at the hospital.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
20398635-7	2010	BDNF significantly decreased food and water intake, and body weight gain.	Water	38-43	brain-derived neurotrophic factor	Rattus norvegicus	0-4
6549759-0	1983	Effects of alterations in sodium and water metabolism on urinary excretion of active and inactive kallikrein in man.	Water	37-42	kallikrein related peptidase 4	Homo sapiens	98-108
20439165-3	2010	Hyperosmolar agents, such as hypertonic saline and mannitol, create a luminal osmotic gradient, drawing water into the dehydrated ASL.	Water	104-109	argininosuccinate lyase	Homo sapiens	130-133
20717088-12	2010	In conclusion, Eclipse AAA commissioned at standard SSD can be used to accurately predict dose distributions in water at extended SSD for 6 MV open beams.	Water	112-117	AAA1	Homo sapiens	23-26
21119879-1	2010	Large water fluxes continuously take place between the different compartments of the brain as well as between the brain parenchyma and the blood or cerebrospinal fluid.Disturbances in this well-regulated water homeostasis may have deleterious effects on brain function and may be fatal in cases where water accumulates in the brain following pathologies such as ischemia, haemorrhage, or brain trauma.The molecular pathways by which water molecules cross the blood brain barrier are not well-understood, although the discovery of Aquaporin 4 (AQP4) in the brain improved the understanding of some of these transport processes, particularly under pathological conditions.	Water	6-11	aquaporin 4	Homo sapiens	530-541
21119879-1	2010	Large water fluxes continuously take place between the different compartments of the brain as well as between the brain parenchyma and the blood or cerebrospinal fluid.Disturbances in this well-regulated water homeostasis may have deleterious effects on brain function and may be fatal in cases where water accumulates in the brain following pathologies such as ischemia, haemorrhage, or brain trauma.The molecular pathways by which water molecules cross the blood brain barrier are not well-understood, although the discovery of Aquaporin 4 (AQP4) in the brain improved the understanding of some of these transport processes, particularly under pathological conditions.	Water	6-11	aquaporin 4	Homo sapiens	543-547
21119879-1	2010	Large water fluxes continuously take place between the different compartments of the brain as well as between the brain parenchyma and the blood or cerebrospinal fluid.Disturbances in this well-regulated water homeostasis may have deleterious effects on brain function and may be fatal in cases where water accumulates in the brain following pathologies such as ischemia, haemorrhage, or brain trauma.The molecular pathways by which water molecules cross the blood brain barrier are not well-understood, although the discovery of Aquaporin 4 (AQP4) in the brain improved the understanding of some of these transport processes, particularly under pathological conditions.	Water	204-209	aquaporin 4	Homo sapiens	530-541
21119879-1	2010	Large water fluxes continuously take place between the different compartments of the brain as well as between the brain parenchyma and the blood or cerebrospinal fluid.Disturbances in this well-regulated water homeostasis may have deleterious effects on brain function and may be fatal in cases where water accumulates in the brain following pathologies such as ischemia, haemorrhage, or brain trauma.The molecular pathways by which water molecules cross the blood brain barrier are not well-understood, although the discovery of Aquaporin 4 (AQP4) in the brain improved the understanding of some of these transport processes, particularly under pathological conditions.	Water	204-209	aquaporin 4	Homo sapiens	543-547
21119879-1	2010	Large water fluxes continuously take place between the different compartments of the brain as well as between the brain parenchyma and the blood or cerebrospinal fluid.Disturbances in this well-regulated water homeostasis may have deleterious effects on brain function and may be fatal in cases where water accumulates in the brain following pathologies such as ischemia, haemorrhage, or brain trauma.The molecular pathways by which water molecules cross the blood brain barrier are not well-understood, although the discovery of Aquaporin 4 (AQP4) in the brain improved the understanding of some of these transport processes, particularly under pathological conditions.	Water	204-209	aquaporin 4	Homo sapiens	530-541
21119879-1	2010	Large water fluxes continuously take place between the different compartments of the brain as well as between the brain parenchyma and the blood or cerebrospinal fluid.Disturbances in this well-regulated water homeostasis may have deleterious effects on brain function and may be fatal in cases where water accumulates in the brain following pathologies such as ischemia, haemorrhage, or brain trauma.The molecular pathways by which water molecules cross the blood brain barrier are not well-understood, although the discovery of Aquaporin 4 (AQP4) in the brain improved the understanding of some of these transport processes, particularly under pathological conditions.	Water	204-209	aquaporin 4	Homo sapiens	543-547
20228119-7	2010	In further testing, when rats were given access to both water and 1.5% saline, animals that received an Ang II treatment regimen drank less water than control animals, but saline intake was unaffected.	Water	56-61	angiogenin	Rattus norvegicus	104-107
20228119-7	2010	In further testing, when rats were given access to both water and 1.5% saline, animals that received an Ang II treatment regimen drank less water than control animals, but saline intake was unaffected.	Water	140-145	angiogenin	Rattus norvegicus	104-107
20237946-2	2010	Therefore, we conducted a prospective study to assess whether tap water from the domestic environment of neutropenic patients poses a risk for infections from the waterborne pathogens nontuberculous mycobacteria (NTM), Legionella spp., and Pseudomonas aeruginosa.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
20237946-3	2010	MATERIALS AND METHODS: Tap water samples were taken in the homes of 65 hemato-oncologic patients who were discharged from the hospital whilst neutropenic and had a suspected period of neutropenia of a minimum of 10 days.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
20494396-3	2010	The benefits produced by using ozone were appreciable even visually since the final effluent of the process looked like tap water.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
20494397-2	2010	Water samples with different calcium hardness were prepared by continuous evaporation of tap water using a laboratory cooling tower.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	89-92
20411914-3	2010	The structural rearrangement around alpha3, which is induced by the water molecular migration to the interior part of the protein during the formation of pB", makes the joint region between beta1 and the N-terminal domain flexible and induces the structural displacement of beta1 and the N-terminal domain.	Water	68-73	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	190-195
20411914-3	2010	The structural rearrangement around alpha3, which is induced by the water molecular migration to the interior part of the protein during the formation of pB", makes the joint region between beta1 and the N-terminal domain flexible and induces the structural displacement of beta1 and the N-terminal domain.	Water	68-73	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	274-279
20202646-0	2010	Silica coated magnetite particles for magnetic removal of Hg2+ from water.	Water	68-73	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	58-61
20458072-3	2010	AQP4 is the major water channel in the CNS, but it is also expressed in fast-twitch skeletal muscle fibers.	Water	18-23	aquaporin 4	Homo sapiens	0-4
20395849-8	2010	RESULTS: Infusion of D-glucose led to 2.9-fold up-regulation in SGLT1 compared with water or iso-osmotic D-mannitol; this effect was replicated by D-fructose or saccharin.	Water	84-89	solute carrier family 5 member 1	Rattus norvegicus	64-69
20139166-7	2010	These observations suggest that upregulation of BH4 synthesis in the heart contributes to an acquisition of ischaemic tolerance in late IPC, and the increase in myocardial BH4 content seems to be mediated by the induction of GTPCH via the H(2)O(2)-JAK2 pathway.	Water	239-244	GTP cyclohydrolase 1	Rattus norvegicus	225-230
20490320-3	2010	The aim of this study is to assess whether exogenously added CoQ(9) can protect human liver cells against injuries induced by a water-soluble radical initiator, 2,2"-azobis(2-amidinopropane) dihydrochloride (AAPH) and a lipid-soluble radical initiator, 2,2"-azobis(2,4-dimethylvaleronitrile) (AMVN).	Water	128-133	coenzyme Q9	Homo sapiens	61-66
19725837-0	2010	Recommendations for tap water iontophoresis.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
20469814-5	2010	RESULTS: At high altitude, 7400 ft. to 10,100 ft (2255 m to 3080 m), average CPAP 95th percentile pressure was 9.43 (+/- 0.12) cm H2O.	Water	130-133	centromere protein J	Homo sapiens	77-81
20469814-7	2010	At high altitude, median CPAP pressure was 7.00 (+/- 0.10) cm H2O vs. 7.21 (+/- 0.14) cm.	Water	62-65	centromere protein J	Homo sapiens	25-29
20132873-8	2010	We conclude that aquaporin-4 null mice manifest increased brain edema following subarachnoid hemorrhage as a consequence of reduced elimination of excess brain water.	Water	160-165	aquaporin 4	Mus musculus	17-28
20000363-1	2010	Superhydrophobic surfaces in nature such as legs of water striders can get an extra supporting force from the deformed water surface they contact, leading to an anticipation of using water-repellent surfaces on ship and even submarine hulls to reduce friction drag.	Water	52-57	inositol polyphosphate-5-phosphatase D	Homo sapiens	211-215
20000363-1	2010	Superhydrophobic surfaces in nature such as legs of water striders can get an extra supporting force from the deformed water surface they contact, leading to an anticipation of using water-repellent surfaces on ship and even submarine hulls to reduce friction drag.	Water	119-124	inositol polyphosphate-5-phosphatase D	Homo sapiens	211-215
20000363-1	2010	Superhydrophobic surfaces in nature such as legs of water striders can get an extra supporting force from the deformed water surface they contact, leading to an anticipation of using water-repellent surfaces on ship and even submarine hulls to reduce friction drag.	Water	119-124	inositol polyphosphate-5-phosphatase D	Homo sapiens	211-215
20117794-1	2010	BACKGROUND: Recently, a highly specific serum autoantibody was discovered in patients with neuromyelitis optica, called NMO-IgG, and aquaporin-4, the most abundant water channel in the CNS, was identified as the target antigen.	Water	164-169	aquaporin 4	Homo sapiens	133-144
20405985-8	2010	Additional studies of the ST2 model of water show similar behavior, which suggests that these are quite general properties of confined fluids.	Water	39-44	ST2	Homo sapiens	26-29
20210356-8	2010	The mean fractional abundance of the syn isomer of DP (f(syn)) was 0.34 +/- 0.10 in all water samples, a value indistinguishable from that of a commercial mixture (f(syn) = 0.35), indicating the source was local.	Water	88-93	synemin	Homo sapiens	37-40
20007828-10	2010	Development of EAU was completely suppressed by TCDD injection, and suppression was abolished by treatment with anti-CD25 mAb before TCDD injection.	Water	15-18	interleukin 2 receptor, alpha chain	Mus musculus	117-121
20701008-9	2010	CONCLUSIONS: We established a direct correlation between the level of methemoglobin and the nitrate concentrations in water samples.	Water	118-123	hemoglobin subunit gamma 2	Homo sapiens	70-83
20071343-1	2010	The plasma membrane assembly of aquaporin-4 (AQP4) water channels into orthogonal arrays of particles (OAPs) involves interactions of AQP4 N-terminal domains.	Water	51-56	aquaporin 4	Homo sapiens	32-43
20071343-1	2010	The plasma membrane assembly of aquaporin-4 (AQP4) water channels into orthogonal arrays of particles (OAPs) involves interactions of AQP4 N-terminal domains.	Water	51-56	aquaporin 4	Homo sapiens	45-49
20071343-1	2010	The plasma membrane assembly of aquaporin-4 (AQP4) water channels into orthogonal arrays of particles (OAPs) involves interactions of AQP4 N-terminal domains.	Water	51-56	aquaporin 4	Homo sapiens	134-138
20149665-0	2010	Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl.	Water	54-59	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	174-181
20379047-11	2010	These results suggest that the main source of superoxide by metabolic stimuli is cardiac myocytes and Mn-SOD is a scavenger from superoxide to H(2)O(2).	Water	143-148	superoxide dismutase 2	Rattus norvegicus	102-108
20116975-5	2010	RESULTS: Immunofluorescence labeling showed that Dsg1 distributed on corneocytes of the outermost SC with a characteristic pattern at the periphery, or over the entire surface, and differences in this distribution pattern correlated with the transepidermal water loss (TEWL).	Water	257-262	desmoglein 1	Homo sapiens	49-53
20033346-11	2010	Among these genes are the chloride/bicarbonate exchanger SLC26A3 and the water channel aquaporin 4.	Water	73-78	solute carrier family 26, member 3	Mus musculus	57-64
21069159-6	2010	The osmotic water permeability coefficient (P(f)) of GLUT1 and the three clinical isolates increased in parallel with the rate of CH3As(OH)2 uptake.	Water	12-17	solute carrier family 2 member 1	Homo sapiens	53-58
21069159-8	2010	These results indicate that CH3As(OH)2 and water use a common translocation pathway in GLUT1 that is different to that of glucose transport.	Water	43-48	solute carrier family 2 member 1	Homo sapiens	87-92
19939403-0	2010	Phase behavior of Phytantriol/water bicontinuous cubic Pn3m cubosomes stabilized by Laponite disc-like particles.	Water	30-35	sodium voltage-gated channel alpha subunit 10	Homo sapiens	55-58
19941943-7	2010	The permeability coefficient of caffeine in ethanol/water was determined to be 1.56 E-08 cm/s and was improved to 2.27 E-08 cm/s by the addition of NAC.	Water	52-57	X-linked Kx blood group	Homo sapiens	148-151
19184627-6	2010	The TII concentration for tap water was close to that of Lake Mead (approximately 90 nM); however, tap water contained no detectable iodide as a result of ozonation and chlorine treatment which converts all of the iodide to iodate.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
19184627-6	2010	The TII concentration for tap water was close to that of Lake Mead (approximately 90 nM); however, tap water contained no detectable iodide as a result of ozonation and chlorine treatment which converts all of the iodide to iodate.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
19551886-1	2010	In the present work, we have found by an atomistic molecular dynamics simulation that hydrogen atoms originating from the residues of a prokaryotic ClC protein (EcClC) stabilize the chloride ion without water molecules in the pore of ClC protein.	Water	203-208	Charcot-Leyden crystal galectin	Homo sapiens	148-151
19551886-1	2010	In the present work, we have found by an atomistic molecular dynamics simulation that hydrogen atoms originating from the residues of a prokaryotic ClC protein (EcClC) stabilize the chloride ion without water molecules in the pore of ClC protein.	Water	203-208	Charcot-Leyden crystal galectin	Homo sapiens	163-166
20002318-1	2010	Experimental evidence demonstrates a higher efficiency of water and nitrogen use in C(4) compared with C(3) plants, which is hypothesized to drive differences in biomass allocation between C(3) and C(4) species.	Water	58-63	complement C3	Homo sapiens	189-193
20517941-8	2010	INTERPRETATION: These results suggest that AQP4 plays a protective role after contusion SCI by facilitating the clearance of excess water, and that targeting edema after SCI may be a novel therapeutic strategy.	Water	132-137	aquaporin 4	Mus musculus	43-47
20189781-6	2010	RALA acts as a chaotropic agent, interfering in the structure of the water, and causes a measurable swelling of the aqueous cylinders by 5A.	Water	69-74	RAS like proto-oncogene A	Homo sapiens	0-4
20233016-4	2010	For pH normalization, 17 times more tap water than Diphoterine was required.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
22347240-3	2010	The aim of this study was to investigate the prevalence of Acanthamoeba in tap-water samples in Iran.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
22347240-4	2010	METHOD: In this descriptive cross-sectional study, 94 samples of cold and warm tap-water were collected from different wards of hospitals in 13 cities of Iran in 2007-2008.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
20345719-1	2010	BACKGROUND AND OBJECTIVE: Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia miltiorrhiza Bunge, a herb that is widely used for atherothrombotic disease treatment in Asian medicine.	Water	56-61	serum amyloid A cluster	Mus musculus	46-49
20176471-7	2010	Moreover the functioning of the thionine-tyrosinase CPE was validated following a biodegradation process of water polluted by BPA and comparing the time changes of BPA concentration inferred by the biosensor calibration curve and those determined by means of HPLC measurements.	Water	108-113	tyrosinase	Homo sapiens	41-51
20193947-0	2010	A water-soluble ribosyl-based fluorescent sensor for Hg2+ and Cu2+ ions.	Water	2-7	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	53-56
20000432-2	2010	Pluronic P85 forms a rich phase behavior when dissolved in water.	Water	59-64	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	9-12
20146744-4	2010	In a strain overexpressing AQY1, the activation energy for water transport increased progressively (from 5.9 to 12.7 kcal mol(-1)) for increasing ethanol concentrations (up to 12% v/v), indicating that mediated water transport lost importance as compared with water diffusion through the bilayer.	Water	59-64	Aqy1p	Saccharomyces cerevisiae S288C	27-31
20146744-4	2010	In a strain overexpressing AQY1, the activation energy for water transport increased progressively (from 5.9 to 12.7 kcal mol(-1)) for increasing ethanol concentrations (up to 12% v/v), indicating that mediated water transport lost importance as compared with water diffusion through the bilayer.	Water	211-216	Aqy1p	Saccharomyces cerevisiae S288C	27-31
20146744-4	2010	In a strain overexpressing AQY1, the activation energy for water transport increased progressively (from 5.9 to 12.7 kcal mol(-1)) for increasing ethanol concentrations (up to 12% v/v), indicating that mediated water transport lost importance as compared with water diffusion through the bilayer.	Water	211-216	Aqy1p	Saccharomyces cerevisiae S288C	27-31
20102466-3	2010	In the present study, we purified and denatured ricin in a boiling water bath for different time intervals.	Water	67-72	ricin	Ricinus communis	48-53
20486565-3	2010	In addition, sterilized water used for handwashing when performing operations has no scientific basis and use of tap water is considered sufficient.	Water	117-122	nuclear RNA export factor 1	Homo sapiens	113-116
20812627-5	2010	The results showed that the average recoveries of antibiotics in tap water and wastewater were 54.9%-130% and 57.4%-138%, respectively, and the corresponding relative standard deviations (RSD, n=3) were 2.85%-28.6% and 2.02%-23.2%, respectively.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
20356447-5	2010	This distribution suggests that AQP4 controls water fluxes into and out of the brain parenchyma.	Water	46-51	aquaporin 4	Homo sapiens	32-36
20356447-6	2010	In cytotoxic edema, AQP4 deletion slows the rate of water entry into brain, whereas in vasogenic edema, AQP4 deletion reduces the rate of water outflow from brain parenchyma.	Water	52-57	aquaporin 4	Homo sapiens	20-24
20356447-6	2010	In cytotoxic edema, AQP4 deletion slows the rate of water entry into brain, whereas in vasogenic edema, AQP4 deletion reduces the rate of water outflow from brain parenchyma.	Water	138-143	aquaporin 4	Homo sapiens	104-108
20047821-6	2010	Water-insoluble antitumor drug, SN-38, was easily encapsulated into CS-g-PCL nanomicelles by lyophilization method.	Water	0-5	polycystic kidney disease 2-like 1	Mus musculus	73-76
19751538-4	2010	Consuming tap water was significantly associated with illness (risk ratio 4.7, 95% confidence interval 1.5-14.4).	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
20122953-2	2010	In this study, we found that NTS1 null mice displayed decreased sensitivity to the ataxic effect of ethanol on the rotarod and increased ethanol consumption when given a free choice between ethanol and tap water containing bottles.	Water	206-211	neurotensin	Mus musculus	29-33
20354224-5	2010	ORAI1, but not ORAI3, channels were inhibited by oxidation by H(2)O(2).	Water	62-68	ORAI calcium release-activated calcium modulator 1	Homo sapiens	0-5
20035838-5	2010	Especially, NT-deficient mice were shown to exhibit reduced SIA following water avoidance or restraint stress.	Water	74-79	neurotensin	Mus musculus	12-14
20035838-10	2010	Accordingly, pretreatment with the NT receptor antagonist SR142948A results in a hyperalgesic response to stress induced by cold-water swim.	Water	129-134	neurotensin	Mus musculus	35-37
20149380-5	2010	Under final working conditions, water samples were adjusted at pH 8.5 and concentrated using a 200mg OASIS HLB SPE cartridge.	Water	32-37	cAMP responsive element binding protein 3 like 1	Homo sapiens	101-106
20175571-4	2010	To understand these interactions of cTnI better, we first investigated the surface chemistry of cTnI as a Langmuir monolayer spread at the air-water interface.	Water	143-148	troponin I3, cardiac type	Homo sapiens	96-100
20064792-0	2010	Relationship between tap water hardness, magnesium, and calcium concentration and mortality due to ischemic heart disease or stroke in The Netherlands.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
20064792-9	2010	For men with the 20% lowest dietary magnesium intake, an inverse association was observed between tap water magnesium intake and stroke mortality (HR per 1 mg/L intake = 0.75; 95% CI, 0.610.91), whereas for women with the 20% lowest dietary magnesium intake, the opposite was observed.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
19875662-3	2010	METHODS: Filensin and CP49 were enriched by urea extraction of lens fiber cell homogenates after the water-soluble fraction was removed.	Water	101-106	beaded filament structural protein 2	Bos taurus	22-26
19796094-9	2010	count in tap water was about 10(4) GU l(-1).	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
20223084-0	2010	Comparative study of sample preparation techniques coupled to GC for the analysis of halogenated acetic acids (HAAs) acids in tap water.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
20033789-4	2010	The study was firstly performed by computer simulations of SAR distribution inside a flat homogeneous phantom, considering various thicknesses of the integrated water bolus.	Water	161-166	sarcosine dehydrogenase	Homo sapiens	59-62
20060312-3	2010	The more lipophilic nature of triphenylphosphonium ion over triethylammonium ion renders P1 and P2 higher octanol/water partition coefficients than P3 and P4.	Water	114-119	crystallin gamma F, pseudogene	Homo sapiens	89-98
19910525-10	2010	Using this model, here we show a dramatic and yet reversible response of the rat small bowel to PAF, suggesting luminal water clearance as a novel safety factor in the intestine that may be of clinical relevance.	Water	120-125	PCNA clamp associated factor	Rattus norvegicus	96-99
19937002-1	2010	A commercially available screen-printed carbon electrode coated with an ex situ deposited bismuth film (BiSPCE) has been applied to the determination of Pb(II) and Zn(II) ions in tap water (Barcelona water distribution network) by means of stripping voltammetry (SV) and stripping chronopotentiometry (SCP).	Water	183-188	nuclear RNA export factor 1	Homo sapiens	179-182
19937002-1	2010	A commercially available screen-printed carbon electrode coated with an ex situ deposited bismuth film (BiSPCE) has been applied to the determination of Pb(II) and Zn(II) ions in tap water (Barcelona water distribution network) by means of stripping voltammetry (SV) and stripping chronopotentiometry (SCP).	Water	200-205	nuclear RNA export factor 1	Homo sapiens	179-182
19926298-2	2010	Artificial mixing of tap water with channeled spring water were found causing temperature decrease, lowering Ra(2+) concentration and inhibiting hokutolite crystallization.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
19926298-2	2010	Artificial mixing of tap water with channeled spring water were found causing temperature decrease, lowering Ra(2+) concentration and inhibiting hokutolite crystallization.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	21-24
20123629-0	2010	Exposure on tap: drinking water as an overlooked source of lead.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	12-15
19858133-0	2010	Strategies to screen and reduce vascular risk--putting statins in the tap water is not the answer.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
19551886-0	2010	Chloride ion conduction without water coordination in the pore of ClC protein.	Water	32-37	Charcot-Leyden crystal galectin	Homo sapiens	66-69
19457500-0	2010	[Is tap water the same as mineral water?	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
19933270-4	2010	Exposure of neutrophils or HEK 293 cells to H(2)O(2) was associated with reduced binding between phosphorylated I kappaB alpha and SCF(beta-TrCP) but no change in the composition of the SCF(beta-TrCP) complex.	Water	44-50	KIT ligand	Homo sapiens	131-134
19995586-8	2010	It was proven that O--&gt;N acyl migration of the precursor isopeptide results in a water soluble oligomeric mixture of neurotoxic A beta(1-42).	Water	84-89	amyloid beta precursor protein	Rattus norvegicus	131-137
19896690-0	2010	Tap water consumers differ from non-consumers in chlorine flavor acceptability but not sensitivity.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
19896690-2	2010	As a consequence, the putative link between sensitivity to chlorine flavor and tap water consumption is an issue in drinking water habits studies.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
19896690-2	2010	As a consequence, the putative link between sensitivity to chlorine flavor and tap water consumption is an issue in drinking water habits studies.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	79-82
20085635-12	2010	Daily use of soap and a safe supply of water are likely to reduce the risk of STH infection.	Water	39-44	saitohin	Homo sapiens	78-81
6549759-2	1983	Several previous studies have examined the response of active kallikrein excretion to alterations in sodium and water metabolism, but the response of inactive kallikrein has not been evaluated systematically.	Water	112-117	kallikrein related peptidase 4	Homo sapiens	62-72
6827108-1	1983	Complement activation in serum via classical or alternative pathway results in the formation of a water-soluble, macromolecular SC5b-9 protein complex consisting of non-covalently associated C5b-C9 complement components and serum S-protein.	Water	98-103	vitronectin	Homo sapiens	230-239
19744778-1	2010	Mineralization of phenazopyridine, 1, in water, under solar-simulator radiation was efficiently achieved using nanoparticle CdS-sensitized rutile TiO(2), TiO(2)/CdS, 2, as photo-catalysts.	Water	41-46	CDP-diacylglycerol synthase 2	Homo sapiens	161-167
19896690-5	2010	In a first experiment, we used the constant stimuli procedure to evaluate the chlorine flavor detection threshold of a group of 20 tap water consumers and a group of 20 non-consumers.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	131-134
19896690-8	2010	Nevertheless, tap water consumers showed a higher liking score for chlorinated solutions and were found to be more inclined to accept these solutions as drinking water.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
19896690-8	2010	Nevertheless, tap water consumers showed a higher liking score for chlorinated solutions and were found to be more inclined to accept these solutions as drinking water.	Water	162-167	nuclear RNA export factor 1	Homo sapiens	14-17
19896690-9	2010	Taken together these findings suggested that consumers may disparage chlorine flavor in drinking water on the basis of their tap water cognitive representation.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	125-128
19896690-9	2010	Taken together these findings suggested that consumers may disparage chlorine flavor in drinking water on the basis of their tap water cognitive representation.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
6586103-4	1983	The product, C3(H2O), is functionally C3b-like and forms a C3 convertase with Factors B and D. The resulting biomolecular enzyme, C3(H2O),Bb, is a serine protease that cleaves C3 generating metastable C3b.	Water	16-19	complement C3	Homo sapiens	38-41
20060383-4	2010	Detailed structural analysis shows that a difference in the conformation of the connecting loop (beta15-beta16) causes the formation of a water molecule-mediated hydrogen bond network between the connecting loop and the catalytic loop in EcSSADH, making the catalytic loop of EcSSADH more rigid compared to that of human SSADH.	Water	138-143	aldehyde dehydrogenase 5 family member A1	Homo sapiens	240-245
20109206-0	2010	Water quality monitoring records for estimating tap water arsenic and nitrate: a validation study.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	48-51
19931118-4	2010	Because limited information is available on the water intake rate in Asian countries, we carried out a nationwide survey using an online questionnaire to assess the direct tap water and beverage consumption within the general Korean population.	Water	176-181	nuclear RNA export factor 1	Homo sapiens	172-175
19931118-8	2010	Indirect tap water intake through the consumption of water-rich dishes occupies 18.5% of average total water intake.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
19931118-8	2010	Indirect tap water intake through the consumption of water-rich dishes occupies 18.5% of average total water intake.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	9-12
19931118-8	2010	Indirect tap water intake through the consumption of water-rich dishes occupies 18.5% of average total water intake.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	9-12
19931118-9	2010	In the summer, the average consumption of direct tap water and beverages increased by up to 19.7 and 7.6%, respectively.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
19945145-0	2010	Quantitative risk assessment of Cryptosporidium in tap water in Ireland.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
20109206-0	2010	Water quality monitoring records for estimating tap water arsenic and nitrate: a validation study.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
20109206-1	2010	BACKGROUND: Tap water may be an important source of exposure to arsenic and nitrate.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
19945145-9	2010	The model indicates a reduced risk of infection from tap water that has undergone microfiltration, as this treatment is more robust in the event of high contamination loads.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
6586103-4	1983	The product, C3(H2O), is functionally C3b-like and forms a C3 convertase with Factors B and D. The resulting biomolecular enzyme, C3(H2O),Bb, is a serine protease that cleaves C3 generating metastable C3b.	Water	16-19	complement C3	Homo sapiens	201-204
6586103-4	1983	The product, C3(H2O), is functionally C3b-like and forms a C3 convertase with Factors B and D. The resulting biomolecular enzyme, C3(H2O),Bb, is a serine protease that cleaves C3 generating metastable C3b.	Water	133-136	complement C3	Homo sapiens	38-41
6586103-4	1983	The product, C3(H2O), is functionally C3b-like and forms a C3 convertase with Factors B and D. The resulting biomolecular enzyme, C3(H2O),Bb, is a serine protease that cleaves C3 generating metastable C3b.	Water	133-136	complement C3	Homo sapiens	201-204
19928871-7	2010	The simulations for the denaturation of the polypeptide GB1 in urea solutions showed that the breaking of its native hydrogen bonds follows a step-by-step process and each step is strongly coupled to the formation of water-carbonyl hydrogen bonds, and to a less extent to the urea-carbonyl hydrogen-bond formation.	Water	217-222	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	56-59
20098622-7	2010	At two months after injection, we found that knockdown of S100a9 expression had improved the cognition decline of Tg2576 mice in the water maze task, and had reduced amyloid plaque burden.	Water	133-138	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	58-64
6586103-6	1983	C3(H2O),Bb produces only three to five metastable C3b molecules per enzyme before being inactivated by regulatory proteins.	Water	3-6	complement C3	Homo sapiens	50-53
19957936-1	2010	Density functional theory (DFT) predicts a detailed mechanism for the reported potential photocatalytic system for solar hydrogen production from water, (P-da-PNN)RuH(CO) (1, P-da = dearomatized at the phosphorus side arm, PNN = (2-(di-tert-butylphosphinomethyl)-6-diethylaminomethyl)pyridine) (Science 2009, 324, 74).	Water	146-151	pinin, desmosome associated protein	Homo sapiens	159-162
6357734-0	1983	[Safety of tap water].	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
19957936-2	2010	In the initial thermal reaction, the coordination of a water molecule is followed by cleavage of an O-H bond and aromatization of the PNN ligand to form (PNN)RuH(CO)(OH) (3"), the most stable complex in the reaction.	Water	55-60	pinin, desmosome associated protein	Homo sapiens	134-137
19957936-4	2010	Next, a second water molecule is activated, resulting in the formation of the cis-dihydroxo complex (PNN)Ru(CO)(OH)(2) (7), which photolytically eliminates H(2)O(2).	Water	15-20	pinin, desmosome associated protein	Homo sapiens	101-104
19957936-4	2010	Next, a second water molecule is activated, resulting in the formation of the cis-dihydroxo complex (PNN)Ru(CO)(OH)(2) (7), which photolytically eliminates H(2)O(2).	Water	156-161	pinin, desmosome associated protein	Homo sapiens	101-104
20356213-3	2010	Here, we demonstrate the spontaneous generation of hydrogen gas from ordinary room-temperature tap water when combined with aluminum-oleic acid core-shell nanoparticles obtained via sonochemistry.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
20000378-1	2010	The crystal structure of human carbonic anhydrase II (HCA II) obtained at 0.9 A resolution reveals that a water molecule, termed deep water, Dw, and bound in a hydrophobic pocket of the active site forms a short, strong hydrogen bond with the zinc-bound solvent molecule, a conclusion based on the observed oxygen-oxygen distance of 2.45 A.	Water	106-111	carbonic anhydrase 2	Homo sapiens	31-52
20000378-1	2010	The crystal structure of human carbonic anhydrase II (HCA II) obtained at 0.9 A resolution reveals that a water molecule, termed deep water, Dw, and bound in a hydrophobic pocket of the active site forms a short, strong hydrogen bond with the zinc-bound solvent molecule, a conclusion based on the observed oxygen-oxygen distance of 2.45 A.	Water	134-139	carbonic anhydrase 2	Homo sapiens	31-52
6343010-0	1983	[Treatment of tap water with chlorine dioxide].	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
19610096-1	2010	Aquaporin-4 (AQP4) is the principle water channel and the primary route for water transport across astrocytic membranes.	Water	36-41	aquaporin 4	Homo sapiens	0-11
19610096-1	2010	Aquaporin-4 (AQP4) is the principle water channel and the primary route for water transport across astrocytic membranes.	Water	36-41	aquaporin 4	Homo sapiens	13-17
19610096-1	2010	Aquaporin-4 (AQP4) is the principle water channel and the primary route for water transport across astrocytic membranes.	Water	76-81	aquaporin 4	Homo sapiens	0-11
19610096-1	2010	Aquaporin-4 (AQP4) is the principle water channel and the primary route for water transport across astrocytic membranes.	Water	76-81	aquaporin 4	Homo sapiens	13-17
19903461-6	2010	Structural constraints evidenced on the free core-SRF are released in the wild-type complex and environmental heterogeneities appear in the vicinity of Tyr residues, due to higher water molecule access.	Water	180-185	serum response factor	Homo sapiens	50-53
7144671-0	1982	Heinz-body haemolysis in haemodialysed patients caused by chloramines in Sydney tap water.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
20390556-0	2010	The use of proactive in-water grooming to improve the performance of ship hull antifouling coatings.	Water	24-29	inositol polyphosphate-5-phosphatase D	Homo sapiens	69-73
20664185-5	2010	Besides increased recreational UV exposure, the patient had a history of occupational radon exposure in a spa with radon-containing water.	Water	132-137	surfactant protein A2	Homo sapiens	106-109
19899114-9	2010	As the salivary gland water channel aquaporin 5 (AQP5) has been proposed to functionally interact with TJs to regulate salivary fluid composition, we also studied glands from AQP5 knock-out mice.	Water	22-27	aquaporin 5	Mus musculus	49-53
19950933-3	2010	Water-soluble sulforhodamine B (SRB) was loaded into the aqueous interior of nanoscale liposomes synthesized in a microfluidic device.	Water	0-5	chaperonin containing TCP1 subunit 4	Homo sapiens	14-30
6288805-0	1982	Nosocomial Legionnaires" disease caused by aerosolized tap water from respiratory devices.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
19950933-3	2010	Water-soluble sulforhodamine B (SRB) was loaded into the aqueous interior of nanoscale liposomes synthesized in a microfluidic device.	Water	0-5	chaperonin containing TCP1 subunit 4	Homo sapiens	32-35
22808388-3	2010	In the present study, the degradation of the carbaryl pesticide was investigated in the laboratory synthetic samples of tap water, in the effect of sonolysis and photolysis processes.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
19234753-9	2010	In several instances, tap water samples collected at the consumers" end of the distribution system did not reflect on the true quality of the treated water.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
6288805-2	1982	Chart review showed that during the two- to 10-day incubation period before the onset of illness, all of the patients inhaled aerosolized tap water from jet nebulizers (four patients) or from a portable room humidifier (one patient), and all received high dosages of corticosteroids or adrenocorticotropic hormone.	Water	142-147	nuclear RNA export factor 1	Homo sapiens	138-141
6288805-4	1982	Environmental cultures yielded Legionella pneumophila from tap water and from reservoirs of tap water-filled respiratory devices.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
20082002-1	2010	New techniques enable a shift in monitoring chemicals that affect water quality from mainly at the end product, tap water, towards monitoring during the whole process along the production chain.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	112-115
21244816-0	2010	Development of low-cost technology for the removal of iron and manganese from ground water in siwa oasis.	Water	85-90	cAMP responsive element binding protein 3 like 1	Homo sapiens	99-104
6288805-5	1982	The yield was highest from hot tap water, in which the free chlorine level was less than 0.05 parts per million.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
21244816-1	2010	BACKGROUND: Ground water is the only water resource for Siwa Oasis.	Water	19-24	cAMP responsive element binding protein 3 like 1	Homo sapiens	61-66
6288805-6	1982	Thus, Legionnaires" disease may be caused by contaminated aerosols from respiratory devices, and the use of contaminated tap water in such devices represents a previously unrecognized hazard to which corticosteroid-treated patients should not be exposed.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
21244816-3	2010	Water samples collected from Siwa Oasis had relatively higher iron (Fe) and manganese (Mn) than the permissible limits specified in WHO Guidelines and Egyptian Standards for drinking water quality.	Water	0-5	cAMP responsive element binding protein 3 like 1	Homo sapiens	34-39
21244816-5	2010	AIM: The study aimed at development of low-cost technology for the removal of iron and manganese from ground water in Siwa Oasis.	Water	109-114	cAMP responsive element binding protein 3 like 1	Homo sapiens	123-128
21109754-2	2010	Here, UMOD forms filamentous structures probably ensuring water impermeability and the countercurrent gradient.	Water	58-63	uromodulin	Homo sapiens	6-10
7129999-2	1982	In 17 studies involving six men, skin temperature (Tsk) was controlled with water-perfused suits first at normothermic levels, followed by a 40- to 50-min period during which Tsk was held at 38-38.5 degrees C. Supine leg exercise at a moderate intensity (100-150 W) was performed for 5-6 min of each 15 min throughout, yielding one period of exercise performed during normothermic conditions and three periods of exercise performed during the period of elevated Tsk.	Water	76-81	tsukushi, small leucine rich proteoglycan	Homo sapiens	51-54
19621257-1	2010	GM1 ganglioside was found to increase the survival of PC12 cells exposed to H(2)O(2), its action was blocked by Trk tyrosine kinase inhibitor K-252a.	Water	76-81	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	112-115
19621257-6	2010	The protective and antioxidative effects of GM1 in PC12 cells exposed to H(2)O(2) appear to be mediated by activation of Trk receptor tyrosine kinase and the protein kinases downstream from this enzyme.	Water	73-78	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	121-124
20512722-6	2010	More than 99% of bacterial cells in the tap water was retained by the RO membranes, leaving &lt;50 cells/mL in the permeate water.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
20512722-6	2010	More than 99% of bacterial cells in the tap water was retained by the RO membranes, leaving &lt;50 cells/mL in the permeate water.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	40-43
6121245-0	1982	Legionnaires" disease related to gastric lavage with tap water.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
20512722-8	2010	In quasi-steady state, the total cell numbers in the biofilm and bulk water were of order 10(3) cells/cm(2) and 10(3) cells/mL, respectively, which were about 2 orders of magnitude lower than those grown in the tap water produced from conventional water treatment.	Water	215-220	nuclear RNA export factor 1	Homo sapiens	211-214
19756968-6	2010	However, after 4 and 6-week PBS incubations, PCL/BG/DBM discs showed significant decrease in modulus (from 266.23 to 54.04 and 33.45 MPa, respectively) in parallel with its highest water uptakes (36.3 and 34.7%).	Water	181-186	PHD finger protein 1	Homo sapiens	45-48
20299767-2	2010	Micellar phase appears in wide composition range with respect to the surfactant mixing fraction in ternary phase diagrams at 25 degrees C. At high mixing fraction of cationic surfactant in the water/CGT-n/CTAB systems, one can observe a highly viscous micellar phase in which worm-like micelles are expected to form.	Water	193-198	UDP glycosyltransferase 8	Homo sapiens	199-202
20299767-3	2010	Contrary to conventional systems in which worm-like micelles are formed, the zero-shear viscosity of the micellar solution in the water/CGT-n/CTAB system with n=1.2 increases with the addition of cationic cosurfactant and once decreases after a maximum, then increases again and decreases after the second maximum.	Water	130-135	UDP glycosyltransferase 8	Homo sapiens	136-139
27819881-16	2010	One study determined the effects of prompt irrigation of the eyes with tap water immediately after alkali burns had been suffered at the scene of injury.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
19939947-0	2010	The role of tobacco Aquaporin1 in improving water use efficiency, hydraulic conductivity, and yield production under salt stress.	Water	44-49	probable aquaporin TIP1-1	Nicotiana tabacum	20-30
19939947-2	2010	The tobacco stress-induced Aquaporin1 (NtAQP1) functions as both water and CO(2) channel.	Water	65-70	probable aquaporin TIP1-1	Nicotiana tabacum	27-37
19939947-2	2010	The tobacco stress-induced Aquaporin1 (NtAQP1) functions as both water and CO(2) channel.	Water	65-70	probable aquaporin TIP1-1	Nicotiana tabacum	39-45
20107258-6	2010	The decrease in the removal efficiency was probably caused by 2-MIB and geosmin remaining in the PAC particle in the treated water of DAF after bubble flotation.	Water	125-130	MIB E3 ubiquitin protein ligase 1	Homo sapiens	64-67
20182069-2	2010	A simulated brine wastewater was prepared from tap water and contained a nitrate concentration of 125 mg/l as N and a total salt concentration of about 1%.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	47-50
20453317-6	2010	SAR values can be lowered by adding either Ca(2 + ) or Mg(2 + ) to desalinated water.	Water	79-84	sarcosine dehydrogenase	Homo sapiens	0-3
20126569-7	2009	These results suggest that AQP5 has a critical role in water-handling, such as the maintenance of airway surface liquid and clearance of alveolar fluid in the mouse respiratory system.	Water	55-60	aquaporin 5	Mus musculus	27-31
19655392-6	2009	The glucose sensitivity of TRITC-apo-GOx/FITC-dextran (500 kDa) assay was estimated to be 0.33%/mM glucose in DI water and 0.5%/mM glucose in SIF and both demonstrated a response in the range of 0-50 mM glucose.	Water	113-118	hydroxyacid oxidase 1	Homo sapiens	37-40
19850941-8	2009	Results further show that CaMKII can be activated by Ang II or H(2)O(2), even in the presence of the Ca(2+) chelator BAPTA-AM, in myocytes and in EGTA-Ca(2+)-free solutions in the presence of the calmodulin inhibitor W-7 in in vitro experiments.	Water	63-68	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	26-32
20009334-3	2009	This method was applied to the recovery tests of copper(II) in human urine, bovine serum and tap water; the results were satisfactory.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
19691418-8	2009	If they were to escape into tap water, then the highest predicted concentrations would still be a factor of between 25 and 40 below the current recommended daily doses of concern.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
19946223-9	2009	CONCLUSIONS: Sparkling water stimulates HCO3- secretion in both the stomach and the duodenum, but the mechanisms involved differ in these two tissues; the response in the former is mainly due to the intracellular supply of HCO3- with the aid of carbonic anhydrase, while in the latter the response is dependent on the NHE1, AE and NBC, and is mediated by endogenous prostaglandins as well as capsaicin-sensitive afferent neurons, in addition to the intracellular supply of HCO3-.	Water	23-28	solute carrier family 9 member A1	Rattus norvegicus	318-322
19765403-6	2009	Morris water maze tests demonstrated significant improvements in learning and memory, especially in rats receiving NT-4-modified fibroblasts.	Water	7-12	neurotrophin 4	Rattus norvegicus	115-119
19925915-8	2009	The proposed method was applied to the analysis of four different sources water samples (tap, well, rain and Yellow River water) and the relative recoveries of spiked water samples are 99.9-115.4%, 101.8-113.7% and 87.3-117.6% at three different concentration levels of 75, 200 and 1000 microg L(-1), respectively.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	89-92
19733901-8	2009	Downstream, water from the road shoulder (W(Sdr)) is of very poor quality with respect to Na and Cl(-), and fair to poor quality regarding K. All other parameters comply with the best quality thresholds (FWQAS and DSPA).	Water	12-17	Secreted decoy of InR	Drosophila melanogaster	44-47
19804887-13	2009	The DLLLME technique shows good linearity (r(2)&gt;or=0.999), good repeatability (RSD: 4.0-12.2% for tap water; 5.7-8.5% for river water) and high sensitivity (LODs: 0.10-0.60microg/L for tap water; 0.11-0.95microg/L for river water).	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
19684307-1	2009	gamma-Glutamyl transpeptidase (GGT) catalyzes the transfer of the glutamyl moiety from glutathione, and glutathione S-conjugates to acceptors to form another amide or to water to produce free glutamate.	Water	170-175	inactive glutathione hydrolase 2	Homo sapiens	0-29
19684307-1	2009	gamma-Glutamyl transpeptidase (GGT) catalyzes the transfer of the glutamyl moiety from glutathione, and glutathione S-conjugates to acceptors to form another amide or to water to produce free glutamate.	Water	170-175	inactive glutathione hydrolase 2	Homo sapiens	31-34
19586572-5	2009	The DCI moiety was present in a water-soluble non-ionic form of which most was shown to be pinitol.	Water	32-37	enoyl-CoA delta isomerase 1	Rattus norvegicus	4-7
19805637-7	2009	Our results demonstrate that both Nox2 and Nox4 are required for the full vasopressor effects of brain Ang-II but that only Nox2 is coupled to the Ang-II-induced water intake response.	Water	162-167	cytochrome b-245 beta chain	Homo sapiens	124-128
20145422-3	2010	MATERIAL AND METHODS: EAU was induced with IRBP1177-1191 peptide or by adoptive transfer of specific T cells in Lewis rats.	Water	22-25	retinol binding protein 3	Rattus norvegicus	43-47
21076224-8	2010	The mobile station effectively decreased conductivity by 98%, COD by 100% and the SAR by 2.15 mgeqv(0.5) in the produced water tested in this study.	Water	121-126	sarcosine dehydrogenase	Homo sapiens	82-85
20057909-3	2009	METHODS: EAU was induced in B10.RIII mice by subcutaneous injection of interphotoreceptor retinoid-binding protein (IRBP) 161-180 emulsified with complete Freund"s adjuvant (CFA) and evaluated by clinical and histopathologic observation.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	116-120
20057909-7	2009	RESULTS: Results showed that EAU was successfully induced by IRBP161-180.	Water	29-32	retinol binding protein 3, interstitial	Mus musculus	61-65
20057909-11	2009	CONCLUSION: The findings revealed that increased IL-21 and IL-21R expression may be involved in the development of EAU, possibly by promoting IL-17 secretion.	Water	115-118	interleukin 21	Mus musculus	49-54
20057909-11	2009	CONCLUSION: The findings revealed that increased IL-21 and IL-21R expression may be involved in the development of EAU, possibly by promoting IL-17 secretion.	Water	115-118	interleukin 21 receptor	Mus musculus	59-65
20057909-11	2009	CONCLUSION: The findings revealed that increased IL-21 and IL-21R expression may be involved in the development of EAU, possibly by promoting IL-17 secretion.	Water	115-118	interleukin 17A	Mus musculus	142-147
19928950-1	2009	Aquaporin-4 (AQP4) is the predominant water channel in the brain.	Water	38-43	aquaporin 4	Homo sapiens	0-11
19928950-1	2009	Aquaporin-4 (AQP4) is the predominant water channel in the brain.	Water	38-43	aquaporin 4	Homo sapiens	13-17
19928950-2	2009	Although AQP4 plays an important role in brain water homeostasis, the molecular mechanisms of AQP4 regulation are not fully understood.	Water	47-52	aquaporin 4	Homo sapiens	9-13
19928950-3	2009	In this report, we show how Zn(2+) rapidly and reversibly decreases the water permeability of AQP4 when it is reconstituted into proteoliposomes.	Water	72-77	aquaporin 4	Homo sapiens	94-98
19928950-6	2009	These results suggest that the water permeability of AQP4 may be regulated by dynamic changes in intracellular Zn(2+) concentration linked to the cellular redox state.	Water	31-36	aquaporin 4	Homo sapiens	53-57
20102592-5	2009	RESULTS: Mean total tap water intake was 1.8 l/day, and women on average spent 146 minutes per week showering and bathing.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
20102592-6	2009	Most tap water intake occurred at home (100% for unemployed, 71.8% for employed).	Water	9-14	nuclear RNA export factor 1	Homo sapiens	5-8
20102592-7	2009	Differences between age groups were observed for total tap water intake overall (p = 0.02) and at home (p = 0.01), and for bottled water intake (p = 0.05).	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
20102592-8	2009	There were differences between ethnic groups for tap water intake at home (p = 0.02) and total tap water intake at work (p = 0.02).	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
20102592-8	2009	There were differences between ethnic groups for tap water intake at home (p = 0.02) and total tap water intake at work (p = 0.02).	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
20102592-9	2009	Total tap water intake at work differed by income category (p = 0.001).	Water	10-15	nuclear RNA export factor 1	Homo sapiens	6-9
19891460-5	2009	The other involves a transient oxocarbenium zwitterionic intermediate, formed by direct attack of C3(PEP) onto C1(A5P), followed by reaction of water at C2.	Water	144-149	complement C3	Homo sapiens	98-117
19783256-6	2009	The richest HMTEOS composition for the water-soluble particles was found to be HMTEOS:PEG6-9=80:20, where the particles had a 6nm diameter core and a 0.8nm thick shell.	Water	39-44	IGF2 antisense RNA	Homo sapiens	86-92
19573562-8	2009	In a water maze task, Glp1r(-/-) mice were impaired in the acquisition phase (p<0.001), and also in the probe recall task (p<0.05).	Water	5-10	glucagon-like peptide 1 receptor	Mus musculus	22-27
19389490-1	2009	NMO-IgG, the auto-antibody specific to the aquaporin-4 (AQP4) water channel associated with the autoimmune inflammatory disease neuromyelitis optica (NMO), is considered to be an accurate serum biomarker and is thought to be an important contributor to NMO pathology.	Water	62-67	aquaporin 4	Homo sapiens	43-54
19389490-1	2009	NMO-IgG, the auto-antibody specific to the aquaporin-4 (AQP4) water channel associated with the autoimmune inflammatory disease neuromyelitis optica (NMO), is considered to be an accurate serum biomarker and is thought to be an important contributor to NMO pathology.	Water	62-67	aquaporin 4	Homo sapiens	56-60
19241465-2	2009	It has been found that the addition of salts to water at pH 3.0 favors the dimerization of beta-lactoglobulin.	Water	48-53	beta-lactoglobulin	Bos taurus	91-109
18998225-1	2009	This study provides the preliminary data set for total dissolved trace metal concentrations in the surface water of the Sava River in Croatia and the assessment of Sava River water quality status.	Water	107-112	T-box transcription factor T	Homo sapiens	120-124
19011982-6	2009	Similarly, physicochemical analysis shows the persistent quality of tap water.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
19011982-7	2009	Based on hardness analysis, bottled and tap water are categorized as soft water.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
19011982-9	2009	It is also important to note that the tap water distribution network in MAYS is a high-pressure recirculation network and there is no chance to grow bacteria in stagnant water in pipe lines or houses.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
19011982-13	2009	Hence, it is the responsibility of the Royal Commission to encourage the peoples in the city to drink tap water as it is as good as bottled water even better than some of the brands and is monitored regularly.	Water	106-111	nuclear RNA export factor 1	Homo sapiens	102-105
19011982-15	2009	Preference for tap water over bottled water will also reduce the production of bottled water that has flooded the market, the enormous strain on the environment, and the pollution due to used empty plastic bottles in the landfill area and will help to keep the city clean.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
19827911-4	2009	Three levels (PAL 1, PAL 2, and PAL 3), distinguished by severity of toxic effects, are developed for 24-hour, 30-day, 90-day, and 2-year durations of potential drinking water and inhalation exposures for the general public.	Water	170-175	BIRC6 antisense RNA 1	Homo sapiens	32-37
19827913-2	2009	Three levels (PAL 1, PAL 2, and PAL 3), distinguished by severity of toxic effects, are developed for 24-hour, 30-day, 90-day, and 2-year durations of potential drinking water and inhalation exposures for the general public.	Water	170-175	BIRC6 antisense RNA 1	Homo sapiens	32-37
19827914-2	2009	Three levels (PAL 1, PAL 2, and PAL 3), distinguished by severity of toxic effects, are developed for 24-hour, 30-day, 90-day, and 2-year durations of potential drinking water and inhalation exposures for the general public.	Water	170-175	BIRC6 antisense RNA 1	Homo sapiens	32-37
19827940-2	2009	Three levels (PAL 1, PAL 2, and PAL 3), distinguished by severity of toxic effects, are developed for 24-hour, 30-day, 90-day, and 2-year durations of potential drinking water and inhalation exposures for the general public.	Water	170-175	BIRC6 antisense RNA 1	Homo sapiens	32-37
20201223-6	2009	Likewise, water-insolubility of 17-allylamino-17-demethoxygeldanamycin (17-AAG), a selective Hps90 inhibitor, constrains its use in humans.	Water	10-15	N-methylpurine DNA glycosylase	Homo sapiens	75-78
19690291-1	2009	IL-17+ T cells make up the majority of the infiltrating cells in the inflamed eye during the development of EAU.	Water	108-111	interleukin 17A	Mus musculus	0-5
19958226-3	2009	METHOD: We formulated and characterized a water-soluble Tam-2-hydroxylpropyl-beta-cyclodextrin (HPbetaCD; 1:2 M) complex.	Water	42-47	ORAI calcium release-activated calcium modulator 1	Homo sapiens	56-61
19570607-0	2009	Continuous flow photocatalytic treatment integrated with separation of titanium dioxide on the removal of phenol in tap water.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
19570607-1	2009	We studied the continuous flow photocatalytic treatment integrated with separation/reuse of titanium dioxide on the removal of phenol (20 mg l(-1)) in electrolytes containing tap water.	Water	179-184	nuclear RNA export factor 1	Homo sapiens	175-178
19648106-4	2009	Tap water was implicated in the outbreak.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
7077258-1	1982	Brine shrimp nauplii challenged with artificial sea water containing 2.5 M NaCl maintain significantly higher levels of cytoplasmic malate dehydrogenase (s-MDH) than larvae incubated in sea water having 0.5 M NaCl.	Water	52-57	malic enzyme 1	Homo sapiens	132-152
19656966-3	2009	By using a newly developed real-time PCR targeting a conserved region of the NP1 gene of HBoV, virus levels in water samples were determined.	Water	111-116	NP-1	Primate bocaparvovirus 1	77-80
6927192-2	1982	Spin-lattice relaxation times, T1, of water hydrogen protons have been determined at random positions within frontal and temporal regions of the human brain.	Water	38-43	spindlin 1	Homo sapiens	0-4
19781967-4	2009	To this end, we have performed molecular dynamics simulations in explicit water of the activated Stat3 homodimer, and also its closely related member of the STAT family, activated Stat1 homodimer.	Water	74-79	signal transducer and activator of transcription 1	Homo sapiens	180-185
7184129-0	1982	[Hydrobiological study of tap water].	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
19693000-8	2009	Furthermore, V1aR is also expressed in collecting duct cells and involved in regulating water reabsorption by affecting V2/aquaporin 2 function.	Water	88-93	arginine vasopressin receptor 1A	Mus musculus	13-17
7240080-4	1981	The basic principle of the procedure is product saturation with brine, followed by trapping of the filth elements from tap water with oliver oil.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
20030191-11	2009	The most recent and important discovery that NMO-IgG reacts specifically with aquaporin 4 (AQP4), which is a water channel localized in astrocytes, opened new avenues for understanding the pathogenesis of NMO/OSMS.	Water	109-114	aquaporin 4	Homo sapiens	78-89
20030191-11	2009	The most recent and important discovery that NMO-IgG reacts specifically with aquaporin 4 (AQP4), which is a water channel localized in astrocytes, opened new avenues for understanding the pathogenesis of NMO/OSMS.	Water	109-114	aquaporin 4	Homo sapiens	91-95
16345688-2	1981	The isolate was able to multiply in tap water without substrates added, but addition of starch and glucose in amounts as low as 1 mug of substrate C per liter clearly enhanced growth.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
19785461-4	2009	In this study, possible pathways for entry of the nonselective antagonist naloxone (NLX) from the water environment into the well-accepted alkaloid binding pocket of a delta opioid receptor (DOR) molecular model based on the beta2-adrenergic receptor crystal structure are explored using microsecond-scale well-tempered metadynamics simulations.	Water	98-103	adrenoceptor beta 2	Homo sapiens	225-250
7225447-1	1981	Reduction of frozen water-glycerol solutions of methemoglobin by thermolysed electrons at 77 degrees K has been studied by Mossbauer spectroscopy.	Water	20-25	hemoglobin subunit gamma 2	Homo sapiens	48-61
19860901-9	2009	In the case of liver alcohol dehydrogenase bound to the inhibitor SAD, it was found that there is a channel just wide enough for a single water molecule to pass through.	Water	138-143	aldo-keto reductase family 1 member A1	Homo sapiens	21-42
6263800-3	1981	The inhibition of MPO-mediated iodination was not solely due to lack of H2O availability as a result of decreased HMS activity but also to a primary inhibition of iodination as shown in a cell-free system with horse-radish peroxidase (HRP) and added H2O2 and sodium iodide.	Water	72-75	myeloperoxidase	Equus caballus	18-21
19678675-1	2009	Poly(vinyl alcohol)-pyrene-glucose oxidase (PVA-Py-GOx), a water-soluble polymer possessing both fluorescent and oxidant sites in the structure, is synthesized by "click" chemistry and modification processes and characterized.	Water	59-64	hydroxyacid oxidase 1	Homo sapiens	51-54
19805165-11	2009	Taken together, these results establish that CaMKKbeta is critically involved in mediating the phosphorylation of AMPK promoted by H(2)O(2) in endothelial cells, and document that eNOS is an important negative regulator of AMPK phosphorylation and intracellular H(2)O(2) generation in endothelial cells.	Water	131-136	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	45-54
7268784-1	1981	Swiss Webster male mice, 22 +/- 3 g, killed 17-18 h following the concomitant oral administration of acetaminophen (350 mg/kg) and N-acetyl-cysteine (NAC, 100-500 mg/kg, treated) had statistically significant lower plasma transaminases (GOT and GPT) than control mice (acetaminophen + water).	Water	285-290	NLR family, pyrin domain containing 1A	Mus musculus	131-162
19725498-0	2009	Metal-ligand cooperation in H2 production and H2O decomposition on a Ru(II) PNN complex: the role of ligand dearomatization-aromatization.	Water	46-49	pinin, desmosome associated protein	Homo sapiens	76-79
19725498-1	2009	The molecular mechanism for H(2) production and H(2)O decomposition on an aromatic Ru(II) PNN complex developed by Milstein and co-workers has been elucidated by detailed density functional theory calculations.	Water	48-53	pinin, desmosome associated protein	Homo sapiens	90-93
7214691-6	1980	Zinc levels were less affected by the dialysis process; before dialysis: tap-water patients, 952 +/- 131 micrograms/L; distilled-water patients, 932 +/- 119 micrograms/L; after dialysis: 1001 +/- 137 micrograms/L, and 934 +/- 121 micrograms/L, respectively.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
19719094-0	2009	Dielectric response of deeply supercooled hydration water in the connective tissue proteins collagen and elastin.	Water	52-57	elastin	Homo sapiens	105-112
19691274-10	2009	The analytical method was applied to triplicate 1 L samples of a chlorinated tap water and a chlorinated indoor pool water.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
6158365-0	1980	Effects of intracerebroventricular administration of tonin on water intake and blood pressure in the rat.	Water	62-67	kallikrein 1-related peptidase C2	Rattus norvegicus	53-58
6158365-1	1980	Intracerebroventricular administration of tonin, an enzyme which releases angiotensin II directly from various substrates, stimulated water intake and increased blood pressure in the rat.	Water	134-139	kallikrein 1-related peptidase C2	Rattus norvegicus	42-47
19691274-11	2009	For the tap water, the digestion efficiency was 47.2% (+/-11.1% relative standard deviation), and the lysine nitrile concentration was 104.6 ng/L (+/-6.8 ng/L standard deviation).	Water	12-17	nuclear RNA export factor 1	Homo sapiens	8-11
7462923-4	1980	A tap water grab sample was collected from each participant"s residence and analyzed for 80 inorganic chemical constituents.	Water	6-11	nuclear RNA export factor 1	Homo sapiens	2-5
19805236-0	2009	Secretin as a neurohypophysial factor regulating body water homeostasis.	Water	54-59	secretin	Homo sapiens	0-8
19805236-5	2009	Considering these findings together with our previous findings that show a direct effect of secretin on renal water reabsorption, we propose here that secretin works at multiple levels in the hypothalamus, pituitary, and kidney to regulate water homeostasis.	Water	110-115	secretin	Homo sapiens	92-100
19805236-5	2009	Considering these findings together with our previous findings that show a direct effect of secretin on renal water reabsorption, we propose here that secretin works at multiple levels in the hypothalamus, pituitary, and kidney to regulate water homeostasis.	Water	110-115	secretin	Homo sapiens	151-159
7444349-4	1980	Secretin induced a significant increase in urinary water, sodium, calcium and solute excretion, and a significant decrease in free water clearance.	Water	51-56	secretin	Homo sapiens	0-8
19805236-5	2009	Considering these findings together with our previous findings that show a direct effect of secretin on renal water reabsorption, we propose here that secretin works at multiple levels in the hypothalamus, pituitary, and kidney to regulate water homeostasis.	Water	240-245	secretin	Homo sapiens	92-100
19805236-5	2009	Considering these findings together with our previous findings that show a direct effect of secretin on renal water reabsorption, we propose here that secretin works at multiple levels in the hypothalamus, pituitary, and kidney to regulate water homeostasis.	Water	240-245	secretin	Homo sapiens	151-159
19944392-3	2009	METHODS: All patients received standard oral hydration: 2000mL of tap water within the 24 hours after coronary angiography.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
19553661-0	2009	Unusual water-mediated antigenic recognition of the proinflammatory cytokine interleukin-18.	Water	8-13	interleukin 18	Homo sapiens	77-91
19586572-11	2009	DCI was neither synthesised endogenously from 2H-labelled water nor converted from [2H6]myo-inositol.	Water	58-63	enoyl-CoA delta isomerase 1	Rattus norvegicus	0-3
7444349-4	1980	Secretin induced a significant increase in urinary water, sodium, calcium and solute excretion, and a significant decrease in free water clearance.	Water	131-136	secretin	Homo sapiens	0-8
7001742-1	1980	Lermontov at the Caucasian Mineral Water spa (on the bicentennial of Pyatigorsk)].	Water	35-40	surfactant protein A2	Homo sapiens	41-44
19553661-14	2009	Third, given the high 125-2H potency, 10 well ordered water molecules are trapped upon complex formation in a cavity between two IL-18 loops and all six 125-2H complementarity-determining regions.	Water	54-59	interleukin 18	Homo sapiens	129-134
7414255-3	1980	h. Urine was collected separately in the three 2 h periods, and blood was drawn every 1 h. Urinary water, sodium, potassium, chloride, calcium, creatinine and solute excretion increased significantly during the 2-h secretin period.	Water	99-104	secretin	Homo sapiens	215-223
19645458-7	2009	Then the positive charged hydrates look more like U1a/b+[(H2O)n+H+] species in structure.	Water	58-61	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	50-53
19771382-3	2009	Relatively low levels of these pollutants were observed, with mean concentrations ranging between 0.51-315.8 lg/kg and 0.05-74.6 ng/L in soil and tap water, respectively.	Water	150-155	nuclear RNA export factor 1	Homo sapiens	146-149
6104487-0	1980	Assignment of the 270 MHz nuclear magnetic resonance spectrum of somatostatin in water.	Water	81-86	somatostatin	Homo sapiens	65-77
19631739-1	2009	This paper presents the development of new pH-sensitive, amphiphilic and biocompatible hydrogels based on alginate-g-PCL, cross-linked with calcium ions to form beads, prepared for controlled delivery of poorly water-soluble drug.	Water	211-216	PHD finger protein 1	Homo sapiens	117-120
19588920-3	2009	A one-pot sequential amidation of the PAA with the amine derivatives of a near-infrared fluorescent dye (ADS832WS) and glucose produced NIRF dye-incorporated water-soluble copolymers.	Water	158-163	interleukin 17B	Homo sapiens	136-140
7369842-4	1980	Felt-pad electrodes soaked in tap water or saline produced the highest mean torque and lowest electrical impedance, which made them excellent choices for single session stimulation.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
19701266-0	2009	When the tap is turned down--restricted water flow increases bacterial contamination after handwashing.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	9-12
19697106-6	2009	The microemulsion system (ME3) containing the highest amount of water (50%) significantly enhanced permeation with Q(24) of 0.746 mg.cm(-2).	Water	64-69	malic enzyme 3	Homo sapiens	26-29
20030210-2	2009	In mammalian brain, Aquaporin-4 (AQP4) is the main water channel and is distributed with highest density in the perivascular and subpial astrocyte end-feet.	Water	51-56	aquaporin 4	Homo sapiens	20-31
20030210-2	2009	In mammalian brain, Aquaporin-4 (AQP4) is the main water channel and is distributed with highest density in the perivascular and subpial astrocyte end-feet.	Water	51-56	aquaporin 4	Homo sapiens	33-37
20030210-3	2009	AQP4 is a critical component of an integrated water and potassium homeostasis.	Water	46-51	aquaporin 4	Homo sapiens	0-4
7356323-4	1980	Positively charged microporous filters were found to efficiently adsorb these coliphages from tap water, sewage, and lake water at neutral pH.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
19746954-4	2009	The complex cis-2 is converted into trans-2 in Et(2)O, whereas in water it is converted into cis-[Fe(OH(2))(2)L(2)](2+), though both of these interconversions are reversible.	Water	66-71	suppressor of cytokine signaling 2	Homo sapiens	12-17
19746954-4	2009	The complex cis-2 is converted into trans-2 in Et(2)O, whereas in water it is converted into cis-[Fe(OH(2))(2)L(2)](2+), though both of these interconversions are reversible.	Water	101-106	suppressor of cytokine signaling 2	Homo sapiens	12-17
19746954-6	2009	The complex cis-2 reacts with CO in water to give trans-[FeCl(CO)L(2)]Cl (trans-6), whereas trans-2 reacts with CO in diethyl ether to give cis-[FeCl(CO)L(2)]Cl (cis-6), though cis-6 isomerizes in water to form trans-6.	Water	36-41	suppressor of cytokine signaling 2	Homo sapiens	12-17
19746954-6	2009	The complex cis-2 reacts with CO in water to give trans-[FeCl(CO)L(2)]Cl (trans-6), whereas trans-2 reacts with CO in diethyl ether to give cis-[FeCl(CO)L(2)]Cl (cis-6), though cis-6 isomerizes in water to form trans-6.	Water	197-202	suppressor of cytokine signaling 2	Homo sapiens	12-17
19393298-2	2009	Aquaporin-4 (AQP4), a predominant water channel of the brain, is restricted to basolateral plasma membranes of ependymal cells.	Water	34-39	aquaporin 4	Mus musculus	0-11
19393298-2	2009	Aquaporin-4 (AQP4), a predominant water channel of the brain, is restricted to basolateral plasma membranes of ependymal cells.	Water	34-39	aquaporin 4	Mus musculus	13-17
19393298-10	2009	Moreover, AQP4 knockout mice showed decreased CSF production and increased brain water content compared with wild-type mice.	Water	81-86	aquaporin 4	Mus musculus	10-14
19533155-4	2009	Here, we demonstrate at the light microscopic and ultrastructural level, the loss of polarized localization of the water channel protein aquaporin-4 (AQP4) in astrocytic endfeet surrounding microvessels during EAE.	Water	115-120	aquaporin 4	Homo sapiens	137-148
19533155-4	2009	Here, we demonstrate at the light microscopic and ultrastructural level, the loss of polarized localization of the water channel protein aquaporin-4 (AQP4) in astrocytic endfeet surrounding microvessels during EAE.	Water	115-120	aquaporin 4	Homo sapiens	150-154
7356323-6	1980	Using this method, coliphages could be concentrated from 17-liter volumes of tap water with recoveries ranging from 34 to 100%.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
19729619-1	2009	Spin-ice materials are magnetic substances in which the spin directions map onto hydrogen positions in water ice.	Water	103-108	spindlin 1	Homo sapiens	0-4
19729619-1	2009	Spin-ice materials are magnetic substances in which the spin directions map onto hydrogen positions in water ice.	Water	103-108	spindlin 1	Homo sapiens	56-60
574944-12	1979	Secretin and urecholine showed similar protein responses during return of pancreatic juice but after diversion, they stimulated water and bicarbonate secretion only.	Water	128-133	secretin	Rattus norvegicus	0-8
19774287-3	2009	In this study, the role of the interplay between solvent water and nitrogen (MEA)-carbon (CO2) bond formation is discussed based on the molecular theory using RISM-SCF-SEDD, which is the hybrid method of quantum chemistry of solute and statistical mechanics of solvent.	Water	57-62	KIT ligand	Homo sapiens	164-167
524564-0	1979	Tap water calcium and its relationship to renal calculi and 24 h urinary calcium output in Great Britain.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
19625604-10	2009	These data indicate that NBCe1 in zebrafish shares many characteristics with mammalian NBCe1, including tissue distribution, importance in systemic water and electrolyte balance, and electrogenic transport of Na+ and HCO3-.	Water	148-153	solute carrier family 4 member 4a	Danio rerio	25-30
19576540-7	2009	Risk was not specific for cKS on the limbs, but it was elevated approximately four- to five-fold with frequent bathing or tap water drinking in communities with high luvisols.	Water	126-131	nuclear RNA export factor 1	Homo sapiens	122-125
19634207-10	2009	have a beneficial role in suppressing the concentrations of haloacetic acids in tap water, which contrasts the historical (albeit erroneous) association of Afipia sp.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
395852-1	1979	A 3-week-old baby, suffering from whooping cough with severe attacks of apnoea and hypoxia, was treated by nasal CPAP with a positive airway pressure of about 5 cm H2O.	Water	164-167	centromere protein J	Homo sapiens	113-117
19779138-9	2009	These results suggest that LPS induces chronic wounds via elevated MAO/B-mediated increases in H(2)O(2) and TNF-alpha activity by epithelial cells and is further associated with more distant effects on systemic oxidative stress and alveolar bone loss.	Water	95-100	monoamine oxidase B	Rattus norvegicus	67-72
19394950-0	2009	TiO2 P-25 anatase rapid precipitation from water by use of struvite formation.	Water	43-48	tubulin polymerization promoting protein	Homo sapiens	5-9
30812313-2	1979	The Milli-Q system fed by distilled water and the Milli-R/Q system fed by tap water both produced water acceptable for microbiological use as measured by the DWST.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
19842489-4	2009	Complexes of C(NH3)2, C(PH3)2, C[P(CH3)3]2, CF2, CCl2, and imidazol-2-ylidene with such proton donors as H2O, HCF3, HCN and HCCH have been analyzed by means of high-level quantum chemical methods.	Water	105-108	ATPase H+ transporting accessory protein 1	Homo sapiens	44-47
19683509-6	2009	A water molecule that is likely to be involved in the nucleotidyl diphosphorylase reaction was observed in the E145A:alpha,beta-imido-dUTP complex and positioned similarly as in the monofunctional trimeric dUTPase.	Water	2-7	Deoxyuridine triphosphatase	Drosophila melanogaster	206-213
19593210-5	2009	[7-D-Ala] was also infused subcutaneously and the ACE2 inhibitor was administrated in drinking water.	Water	95-100	angiotensin I converting enzyme 2	Rattus norvegicus	50-54
30812313-2	1979	The Milli-Q system fed by distilled water and the Milli-R/Q system fed by tap water both produced water acceptable for microbiological use as measured by the DWST.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
19466729-0	2009	An amphiphilic resin-dispersion of nanoparticles of platinum (ARP-Pt): a highly active and recyclable catalyst for the aerobic oxidation of a variety of alcohols in water.	Water	165-170	arginine-glutamic acid dipeptide repeats	Homo sapiens	62-65
505712-0	1979	A quantitative morphological and ecological study of protozoa polluting tap water in Mexico City.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
19466729-2	2009	ARP-Pt 4 was prepared by the reduction of PS-PEG-NH(2)-PtCl(2)(C(2)H(4)) 3, which was generated by mixing PS-PEG-NH(2) 1 and Zeise"s salt 2 (K[PtCl(3)(CH(2)CH(2))]), with benzyl alcohol in water (80 degrees C, 12 h).	Water	189-194	arginine-glutamic acid dipeptide repeats	Homo sapiens	0-3
19586907-3	2009	By comparing the structures, it was determined that the specificity of the relative inhibitors for ADAMTS-5 was not driven by a specific interaction, such as zinc chelation, hydrogen bonding, or charge interactions, but rather by subtle and indirect factors, such as water bridging, ring rigidity, pocket size, and shape, as well as protein conformation flexibility.	Water	267-272	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	99-107
19781389-11	2009	The food intake of male CCK transgenic mice was decreased by 5% - 10% with the same levels of water consumed compared with wild type mice.	Water	94-99	cholecystokinin	Mus musculus	24-27
19556578-3	2009	Rinsing with soapy water followed by tap water was the most effective cleaning method and reduced pathogen load by 3.7 and 3.1 log(10)s at the low and high inoculum levels, respectively.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
156180-4	1979	The degree of hydration was found to be 0.62 ml of H2O/g of ATPase.	Water	51-54	ATPase	Escherichia coli	60-66
19215235-0	2009	Reduced lung water transport rate associated with downregulation of aquaporin-1 and aquaporin-5 in aged mice.	Water	13-18	aquaporin 5	Mus musculus	84-95
19561639-3	2009	In Jurkat T cells and mouse splenocytes, we have found that SOCS1 is induced in response to tumor necrosis factor-alpha or H(2)O(2), concomitant with the activation of Jaks which act as important mediators of reactive oxygen species (ROS)-induced apoptosis upstream of p38 mitogen-activated protein kinase.	Water	123-128	suppressor of cytokine signaling 1	Mus musculus	60-65
19587140-11	2009	Acidic condition-induced V2R enhancement was suppressed by V1aR stimulation, suggesting the crucial role of V1aR in water and electrolyte homeostasis in acidosis.	Water	116-121	arginine vasopressin receptor 1A	Rattus norvegicus	59-63
19587140-11	2009	Acidic condition-induced V2R enhancement was suppressed by V1aR stimulation, suggesting the crucial role of V1aR in water and electrolyte homeostasis in acidosis.	Water	116-121	arginine vasopressin receptor 1A	Rattus norvegicus	108-112
109904-0	1979	Antagonism of vasopressin-induced water flow by somatostatin.	Water	34-39	somatostatin	Homo sapiens	48-60
19684905-2	2009	The construction of this sensor was very easy that allowed a cost-effective detection of Hg2+ with a limit of detection of 4.5 nM, which was lower than the 10 nM toxic level for drinkable water as regulated by the US"s EPA.	Water	188-193	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	89-92
19721966-1	2009	The objective of this study was to analyze the fluoride concentration on the water that flows of the tap in the urban area of the city of Campo Grande (MS).	Water	77-82	nuclear RNA export factor 1	Homo sapiens	101-104
109904-1	1979	The ability of somatostatin to modify the water premeability of the toad bladder was examined.	Water	42-47	somatostatin	Homo sapiens	15-27
19758189-3	2009	Although the exact role and function of NMO-IgG in vivo remain to be determined, recent reports suggest that this antibody that targets the aquaporin-4 (AQP-4) water channel expressed by astrocytes is able to destabilize the blood-brain barrier and contribute to astrocyte and oligodendrocyte damage.	Water	160-165	aquaporin 4	Homo sapiens	140-151
109904-2	1979	Somatostatin had a small effect on basal water flow and antagonized the hydrosmotic effect of vasopressin.	Water	41-46	somatostatin	Homo sapiens	0-12
19758189-3	2009	Although the exact role and function of NMO-IgG in vivo remain to be determined, recent reports suggest that this antibody that targets the aquaporin-4 (AQP-4) water channel expressed by astrocytes is able to destabilize the blood-brain barrier and contribute to astrocyte and oligodendrocyte damage.	Water	160-165	aquaporin 4	Homo sapiens	153-158
468462-6	1979	Equilibrium configurations of associated polar molecules and H2O predicted by the model are found to be in good agreement with those resulting from more sophisticated ab initio SCF calculations.	Water	61-64	KIT ligand	Homo sapiens	177-180
19223077-3	2009	This study also showed that UV/Lamp2, which photolyzes water molecules and generates OH radicals, is more effective for PPCP removal than UV/lamp1.	Water	55-60	lysosomal associated membrane protein 2	Homo sapiens	31-36
221020-5	1979	Moreover, the chlorophyll fluorescence is also quenched by a water-soluble spin label.	Water	61-66	spindlin 1	Homo sapiens	75-79
19673244-1	2009	We report the first joint shipboard and airborne study focused on the chemical composition and water-uptake behavior of particulate ship emissions.	Water	95-100	inositol polyphosphate-5-phosphatase D	Homo sapiens	26-30
19673271-0	2009	Perfluorinated compounds in tap water from China and several other countries.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
19581476-3	2009	We found ARGs and heterotrophic ARB in all finished water and tap water tested, although the amounts were small.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
19581476-4	2009	The quantities of most ARGs were greater in tap water than in finished water and source water.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
221020-8	1979	Fluorescence quenching by a water-soluble spin label within the lipid matrix is observed even in the rigid state of the membrane.	Water	28-33	spindlin 1	Homo sapiens	42-46
19558455-1	2009	We have shown preferential expression of both mRNA and corresponding protein for myosin VI (Myo6) in the murine hippocampus within 24 h after the extreme traumatic experience, water-immersion restraint stress (WIRS), prior to a drastic decrease in neural progenitor proliferation in the dentate gyrus.	Water	176-181	myosin VI	Mus musculus	81-90
19505077-8	2009	Exchanging the positions of MP-11 and GOx on the DNA scaffold eliminated the MP-11-electrocatalyzed reduction of H(2)O(2).	Water	113-118	hydroxyacid oxidase 1	Homo sapiens	38-41
19558455-1	2009	We have shown preferential expression of both mRNA and corresponding protein for myosin VI (Myo6) in the murine hippocampus within 24 h after the extreme traumatic experience, water-immersion restraint stress (WIRS), prior to a drastic decrease in neural progenitor proliferation in the dentate gyrus.	Water	176-181	myosin VI	Mus musculus	92-96
475753-3	1979	For glucose 6-phosphate dehydrogenase, hexokinase and fumarase, enzyme activity became detectable (about 0.05% of the fully hydrated rate) when the water content was about 0.2g/g of reaction mixture, and for phosphoglucose isomerase, around 0.15g/g of reaction mixture.	Water	148-153	glucose-6-phosphate dehydrogenase	Homo sapiens	4-37
19467769-3	2009	A preliminary experiment demonstrated that chitosan was more efficient at color removal in tap water than in demineralized water, and that a substantially lower concentration of chitosan could be used with tap water.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
475753-3	1979	For glucose 6-phosphate dehydrogenase, hexokinase and fumarase, enzyme activity became detectable (about 0.05% of the fully hydrated rate) when the water content was about 0.2g/g of reaction mixture, and for phosphoglucose isomerase, around 0.15g/g of reaction mixture.	Water	148-153	fumarate hydratase	Homo sapiens	54-62
19398170-2	2009	An important pathogenetic mechanism belongs to NMO-IgG autoantibodies directed against the ultrastructure of the water channel aquaporin-4 (AQP4), the so-called orthogonal arrays of particles (OAPs).	Water	113-118	aquaporin 4	Homo sapiens	140-144
427405-0	1979	Tap water instead of electrode jelly for electrocardiographic recording.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
19810459-6	2009	Simulations of water-kerma and dose in water for the CSA1, CSA2, RTR, 3M, and selectron/ LDR 137Cs sources are carried out using the DOSRZnrc code.	Water	15-20	nuclear receptor subfamily 6 group A member 1	Homo sapiens	65-68
19722439-5	2009	RESULTS: Of 194 parents, 134 (69%) gave their children bottled water either exclusively or with tap water.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
19722439-7	2009	Reasons for giving children bottled water included: fear of contaminants in tap water; taste and/or smell of tap water; and convenience of bottled water.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	76-79
19810459-6	2009	Simulations of water-kerma and dose in water for the CSA1, CSA2, RTR, 3M, and selectron/ LDR 137Cs sources are carried out using the DOSRZnrc code.	Water	39-44	nuclear receptor subfamily 6 group A member 1	Homo sapiens	65-68
728452-2	1978	The effect of pressure on the swelling of elastin in pure water was investigated.	Water	58-63	elastin	Homo sapiens	42-49
20948622-2	2009	Over the last few years, a number of patients have been defined with antibodies to voltage-gated (VGKC) or ligand-gated (NMDAR, GlyR) ion channels or ungated water (AQP4) channels.	Water	158-163	aquaporin 4	Homo sapiens	165-169
19523663-0	2009	Composition and particle size of superparamagnetic corrosion products in tap water.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
19445480-3	2009	AQP4 was recently found to have six isoforms, where AQP4a (also known as M1), AQP4c (also known as M23), and AQP4e are functional water transport channels.	Water	130-135	aquaporin 4	Homo sapiens	0-4
693298-0	1978	[Quantitative cytochemical study of local immunostimulation of the respiratory mucosae by mineral spa water (author"s transl)].	Water	102-107	pulmonary surfactant-associated protein A	Oryctolagus cuniculus	98-101
19480412-1	2009	The refractory, water-bound perfluoro-n-alkyl carboxylate F(CF2)nCO2- and sulfonate F(CF2)nSO3- surfactant anions reach remote locations by mechanisms that are not well understood.	Water	16-21	ATPase H+ transporting accessory protein 1	Homo sapiens	60-63
19480412-1	2009	The refractory, water-bound perfluoro-n-alkyl carboxylate F(CF2)nCO2- and sulfonate F(CF2)nSO3- surfactant anions reach remote locations by mechanisms that are not well understood.	Water	16-21	ATPase H+ transporting accessory protein 1	Homo sapiens	86-89
19480412-4	2009	The larger f values for F(CF2)nSO3- over their F(CF2)nCO2- congeners are consistent with a closer approach of the bulkier, less hydrated -SO3- headgroup to the air/water interface.	Water	164-169	ATPase H+ transporting accessory protein 1	Homo sapiens	26-29
709813-2	1978	Tap water is initially treated employing reverse osmosis, followed by treatment with activated charcoal and mixed anion/cation exchange resins.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
19622773-4	2009	Treatment with the parent compound (I3C) or DIM (1 micromol/L) protected against cell killing due to H(2)O(2) and other oxidants, and the protection was abrogated by knockdown of BRCA1.	Water	101-106	BRCA1 DNA repair associated	Homo sapiens	179-184
19456110-2	2009	Spin-unrestricted density functional theory simulations indicate that the dissociation (lysis) of water on these clusters may be thermally driven even in the absence of other electrocatalytically and photocatalytically driven processes.	Water	98-103	spindlin 1	Homo sapiens	0-4
20442823-3	2009	To explore the probable mechanism of H(2)O(2) and t-BHP-induced potentiation of Ang II-mediated contractile response, different blockers such as losartan (AT(1) receptor blocker; 1 muM), catalase (H(2)O(2) scavenger; 500 U/ml), lercanidipine (L-type calcium channel blocker; 1 muM), geinistein (tyrosine kinase inhibitor; 100 muM), and indomethacin (cyclo-oxygenase inhibitor; 10 muM) were used.	Water	37-42	angiogenin	Rattus norvegicus	80-83
683765-0	1978	Tap water scald burns in children.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
19460633-9	2009	Intensive Fos and Fos-B expression was detected in the median preoptic nuclei and paraventricular nuclei in the fetal brain following exposure to maternal water deprivation.	Water	155-160	protein c-Fos	Ovis aries	10-13
18553142-5	2009	SOX deficiency was established by feeding rats a low molybdenum diet and adding to their drinking water 200 ppm tungsten.	Water	98-103	sulfite oxidase	Rattus norvegicus	0-3
683765-1	1978	Tap water scald burns account for 7% to 17% of all childhood scald burns that require hospitalization.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
19460633-9	2009	Intensive Fos and Fos-B expression was detected in the median preoptic nuclei and paraventricular nuclei in the fetal brain following exposure to maternal water deprivation.	Water	155-160	protein fosB	Ovis aries	18-23
19077100-2	2009	Scabies burrows, the only pathognomonic lesion for scabies, often occur on the creases of the palms, and are followed by a pattern of scale reminiscent of the "wake" left on the surface of water by a moving bird or a ship (wake sign).	Water	189-194	inositol polyphosphate-5-phosphatase D	Homo sapiens	217-221
633097-4	1978	Na+ and water were found to be reabsorbed by the perfused rat cauda epididymidis at the rates of 3.000 +/- 0.25 n-equiv cm-1 min-1 (mean +/- S.E., n = 14) and 20.7 +/- 1.7 nl.	Water	8-13	Cardiac mass QTL 1	Rattus norvegicus	120-130
19394950-1	2009	UV(360nm) irradiation of TiO(2) P-25 nanoparticle in water suspension is used for photocatalytic mineralization of pollutants or inactivation of microorganisms.	Water	53-58	tubulin polymerization promoting protein	Homo sapiens	32-36
19117672-6	2009	The procedure was applied to tap water, well water, river water and sea water, and accuracy was assessed through the analysis of certified reference water or recovery experiments.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
19386853-2	2009	Epidemiological studies and molecular comparisons of Mycobacterium chelonae strains from different patients and the environment suggested that contamination may be associated with inappropriate cleaning of the multiple-injection device with tap water.	Water	245-250	nuclear RNA export factor 1	Homo sapiens	241-244
19436108-7	2009	In vivo, water restriction of rats or mice led to increased urine osmolality, increased Sgk1 expression, increased expression of the type A natriuretic peptide receptor (NPR-A), and dehydration natriuresis.	Water	9-14	natriuretic peptide receptor 1	Mus musculus	170-175
19240359-1	2009	We examined whether the average water residence time, the time it takes water to travel from the treatment plant to the user, for a zip code was related to the proportion of emergency department (ED) visits for gastrointestinal (GI) illness among residents of that zip code.	Water	32-37	death associated protein kinase 3	Homo sapiens	132-135
652514-9	1978	These finding indicate the need of a routine measure of metal content - mainly aluminium and manganese - in tap water used for dialysis, in order to treat this water if necessary.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
19124200-0	2009	Octadecyl bonded silica membrane disk modified with Cyanex302 for separation and flame atomic absorption spectrometric determination of nickel from tap water and industrial effluent.	Water	152-157	nuclear RNA export factor 1	Homo sapiens	148-151
19124200-4	2009	The method applied for detection of nickel in tap water and effluent sample had a relative standard deviation (R.S.D.)	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
19168337-15	2009	l-Arginine in drinking water has a beneficial effect in the enhancement of eNOS protein expression.	Water	23-28	nitric oxide synthase, endothelial	Oryctolagus cuniculus	75-79
652514-9	1978	These finding indicate the need of a routine measure of metal content - mainly aluminium and manganese - in tap water used for dialysis, in order to treat this water if necessary.	Water	160-165	nuclear RNA export factor 1	Homo sapiens	108-111
356498-4	1978	Biliary water and electrolytes are augmented by gastrin, CCK-PZ, secretin and VIP and inhibited by Substance P.	Water	8-13	secretin	Homo sapiens	65-73
19288182-5	2009	RESULTS: mrp1 ((-/-)) mice more severely decreased body weight, food and water intake than mrp1 ((+/+)) mice.	Water	73-78	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	9-13
19426743-8	2009	However, compared to bacteria, eukaryotic cytosolic LeuRS editing domains contain an extra helix that closes over the active site, largely burying the adduct and providing additional direct and water-mediated contacts.	Water	194-199	leucyl-tRNA synthetase 1	Homo sapiens	52-57
20174369-1	1978	A laser beam of 1-mrad divergence in water focuses to a thin horizontal line when propagating down a horizontal plastic tube filled with aerated tap water of temperature less than ambient.	Water	149-154	nuclear RNA export factor 1	Homo sapiens	145-148
620492-7	1978	An intravenous water load given then further increased urinary kallikrein activity.	Water	15-20	kallikrein related peptidase 4	Homo sapiens	63-73
620492-8	1978	White subjects were studied for an additional 24 h period, and urinary kallikrein activity returned to pre-water load values, indicating that the excretion of a water load in sodium-depleted subjects is associated with an increase in kallikrein excretion.	Water	161-166	kallikrein related peptidase 4	Homo sapiens	71-81
620492-8	1978	White subjects were studied for an additional 24 h period, and urinary kallikrein activity returned to pre-water load values, indicating that the excretion of a water load in sodium-depleted subjects is associated with an increase in kallikrein excretion.	Water	161-166	kallikrein related peptidase 4	Homo sapiens	234-244
328126-6	1977	However, their absorption and toxicity in the newborn are unknown and, unless use of a skin disinfectant is warranted, routine bathing of newborns with tap water appears to be satisfactory.	Water	156-161	nuclear RNA export factor 1	Homo sapiens	152-155
409556-2	1977	The passive water permeability (Lp) of the mucosa is 6 times higher during absorption (mucosa to serosa: 70 microliter/h/mOsm) than in the opposite direction (secretion: 11.5 microliter/h/mOsm) and its semi permeability is 0.49 (reflexion coefficient sigma).	Water	12-17	oncostatin M	Mus musculus	121-125
409556-2	1977	The passive water permeability (Lp) of the mucosa is 6 times higher during absorption (mucosa to serosa: 70 microliter/h/mOsm) than in the opposite direction (secretion: 11.5 microliter/h/mOsm) and its semi permeability is 0.49 (reflexion coefficient sigma).	Water	12-17	oncostatin M	Mus musculus	188-192
323448-5	1977	In the preterm infants exhibiting short responses, the peak inspiratory pressure generated in response to occlusion rose on CPAP from 3.4 to 7.1 cm H2O (p less than 0.005), while respiratory rate fell from 61 to 49 breaths/minute (p less than 0.025).	Water	148-151	centromere protein J	Homo sapiens	124-128
848484-5	1977	A subsequent matched-pair case-control study which excluded persons who had visted the spa showed that a history of consumption of the bottled non-carbonated water was significantly more common among bacteriologically confirmed cholera cases than among paired controls.	Water	158-163	surfactant protein A2	Homo sapiens	87-90
838218-2	1977	It was found that intravenous secretin abolished the net water absorption from bile in the gallbladder and thereby impeded its concentrating mechanism, but alone did not influence gallbladder motility.	Water	57-62	secretin	Homo sapiens	30-38
838218-3	1977	It was sometimes seen that secretin even reversed the net water transport in the gallbladder, producing a secretion.	Water	58-63	secretin	Homo sapiens	27-35
189808-1	1977	Water-soluble spin labels were used to study dimyristoyllecithin (DML) phospholipid multilayers.	Water	0-5	spindlin 1	Homo sapiens	14-18
189808-4	1977	A phosphate-containing spin label demonstrated strong an isotropic motion in the lipid-water system above the phase transition but not below.	Water	87-92	spindlin 1	Homo sapiens	23-27
16659828-2	1977	Water potential showed a continuous decrease toward the tip, with a 2- to 4-bar difference between leaf base and tip under both moist and dry soil conditions.	Water	0-5	NAC domain-containing protein 74	Zea mays	56-59
16659828-2	1977	Water potential showed a continuous decrease toward the tip, with a 2- to 4-bar difference between leaf base and tip under both moist and dry soil conditions.	Water	0-5	NAC domain-containing protein 74	Zea mays	113-116
16659840-8	1977	One of the remaining corn bands was shown to be a peroxidase.Superoxide dismutase accounted for 1.6 to 2.4% of the water-soluble protein in seedlings of corn, peas, and oats (Avena sativa L., cv.	Water	115-120	superoxide dismutase	Zea mays	61-81
17269-6	1977	When intact elastin is photolysed for 20 minutes in water, approximately 75% of the (iso) desmosines are destroyed, accompanied by an increase of free lysine residues.	Water	52-57	elastin	Homo sapiens	12-19
17274-1	1977	The coacervate phase produced by raising the temperature of solutions of blocked alpha-elastin has water content and fibrillar structure at electron microscope level similar to fibrous elastin (Cox, B.A., Starcher, B.C., Urry, D.W. (1973) Biochim, Biophys.	Water	99-104	elastin	Homo sapiens	87-94
18342-6	1977	Catalytic activity of both forms of citrate synthase is inhibited by incubation in distilled water; osmoconformer citrate synthase was inhibited completely in 7 h while osmoregulator citrate synthase was inhibited only 60% in this time and 80% after 22 h in distilled water.	Water	93-98	citrate synthase	Sus scrofa	36-52
18342-6	1977	Catalytic activity of both forms of citrate synthase is inhibited by incubation in distilled water; osmoconformer citrate synthase was inhibited completely in 7 h while osmoregulator citrate synthase was inhibited only 60% in this time and 80% after 22 h in distilled water.	Water	93-98	citrate synthase	Sus scrofa	114-130
18342-6	1977	Catalytic activity of both forms of citrate synthase is inhibited by incubation in distilled water; osmoconformer citrate synthase was inhibited completely in 7 h while osmoregulator citrate synthase was inhibited only 60% in this time and 80% after 22 h in distilled water.	Water	93-98	citrate synthase	Sus scrofa	114-130
18342-6	1977	Catalytic activity of both forms of citrate synthase is inhibited by incubation in distilled water; osmoconformer citrate synthase was inhibited completely in 7 h while osmoregulator citrate synthase was inhibited only 60% in this time and 80% after 22 h in distilled water.	Water	268-273	citrate synthase	Sus scrofa	36-52
18342-6	1977	Catalytic activity of both forms of citrate synthase is inhibited by incubation in distilled water; osmoconformer citrate synthase was inhibited completely in 7 h while osmoregulator citrate synthase was inhibited only 60% in this time and 80% after 22 h in distilled water.	Water	268-273	citrate synthase	Sus scrofa	114-130
18342-6	1977	Catalytic activity of both forms of citrate synthase is inhibited by incubation in distilled water; osmoconformer citrate synthase was inhibited completely in 7 h while osmoregulator citrate synthase was inhibited only 60% in this time and 80% after 22 h in distilled water.	Water	268-273	citrate synthase	Sus scrofa	114-130
185095-6	1976	Although angiotensin II is essential for the initiation of the elevated blood pressure, the renin--angiotensin system plays a decreasing role in the maintenance of the chronic hypertension as sodium and water are retained, and plasma volume increases.	Water	203-208	renin	Canis lupus familiaris	92-97
993333-3	1976	Glutamine B10 and histidine E7 (the distal histidine) swing towards each other and, between them, stabilize a water molecule in the normally hydrophobic heme pocket.	Water	110-115	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	10-13
977572-8	1976	The s20, w and v of the toxin-nAChR complex in 0.1% Triton were determined by velocity sedimentation in D2O and H2O sucrose gradients.	Water	112-115	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	30-35
988564-3	1976	These equations show an important difference between the two groups of experiments: in water, both Tsk and Tre are required, whereas Tsk suffices in air.	Water	87-92	tsukushi, small leucine rich proteoglycan	Homo sapiens	99-102
1272637-8	1976	These findings strongly suggest that the mucin became smaller and more dense as calcium was added, a process most probably achieved by loss of intramolecular water.	Water	158-163	solute carrier family 13 member 2	Rattus norvegicus	41-46
950263-5	1976	Time curves of the antidiuretic responses expressed in changes of urine osmolality (Uosm) and free water clearance per 100 ml GFR (CH2O X 100/GFR) are described.	Water	99-104	Rap guanine nucleotide exchange factor 5	Homo sapiens	126-129
19345723-1	2009	The glial cell water channel aquaporin-4 (AQP4) plays an important role in brain edema, astrocyte migration, and neuronal excitability.	Water	15-20	aquaporin 4	Mus musculus	29-40
19345723-1	2009	The glial cell water channel aquaporin-4 (AQP4) plays an important role in brain edema, astrocyte migration, and neuronal excitability.	Water	15-20	aquaporin 4	Mus musculus	42-46
19401454-9	2009	Treatment with H(2)O(2) increased the abundance of NOX2, HSF1, and PAI-1 in EC.	Water	15-20	cytochrome b-245 beta chain	Homo sapiens	51-55
18953497-3	2009	Tap water in few locations in Europe contains up to 139 microg/L mostly bound to humic substances, probably leaching from marine sediments in the aquifers.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
18823399-7	2009	Young water found in the PSW also was present in UFA monitoring wells that tap a highly transmissive zone (43- to 53-m depth) in the UFA.	Water	6-11	nuclear RNA export factor 1	Homo sapiens	75-78
949571-1	1976	The concentrations of 20 trace elements were determined by atomic absorption spectrophotometry on representative samples of tap-water collected from 48 local authority areas in South Wales.	Water	128-133	nuclear RNA export factor 1	Homo sapiens	124-127
19487934-12	2009	Subjects with an increase in BAL fluid MMP-9 during the 4-day period had lower EVLW measurements than those in whom MMP-9 fell (10 vs. 17 mL/kg, p = 0.004): change in lung water correlated inversely with change in MMP-9, r = -.54, p = 0.0296.	Water	172-177	matrix metallopeptidase 9	Homo sapiens	39-44
19394883-0	2009	Water molecule contributions to proton spin-lattice relaxation in rotationally immobilized proteins.	Water	0-5	spindlin 1	Homo sapiens	39-43
187115-0	1976	Concentration of viruses from large volumes of tap water using pleated membrane filters.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
19394883-1	2009	Spin-lattice relaxation rates of protein and water protons in dry and hydrated immobilized bovine serum albumin were measured in the range of (1)H Larmor frequency from 10 kHz to 30 MHz at temperatures from 154 to 302 K. The water proton spin-lattice relaxation reports on that of protein protons, which causes the characteristic power law dependence on the magnetic field strength.	Water	225-230	spindlin 1	Homo sapiens	0-4
19394883-2	2009	Isotope substitution of deuterium for hydrogen in water and studies at different temperatures expose three classes of water molecule dynamics that contribute to the spin-lattice relaxation dispersion profile.	Water	50-55	spindlin 1	Homo sapiens	165-169
19394883-2	2009	Isotope substitution of deuterium for hydrogen in water and studies at different temperatures expose three classes of water molecule dynamics that contribute to the spin-lattice relaxation dispersion profile.	Water	118-123	spindlin 1	Homo sapiens	165-169
19394883-6	2009	It is shown using isotope substitution that the exponent of the power law of the water signal in hydrated immobilized protein systems is the same as that for protons in lyophilized proteins over four orders of magnitude in the Larmor frequency, which implies that changes in the protein structure associated with hydration do not affect the (1)H spin relaxation.	Water	81-86	spindlin 1	Homo sapiens	346-350
19586601-1	2009	During hair coloring a number of disulfide bonds in cystine are oxidized (1) to create cysteic acid, forming binding sites for metal ions such as Ca(2+ )and Cu(2+ )from tap water (2).	Water	173-178	nuclear RNA export factor 1	Homo sapiens	169-172
19586601-5	2009	Nanoscale secondary ion mass spectrometry (NanoSIMS) has been used to locate the calcium and copper within hair that has been treated with a colorant and washed multiple times in tap water containing these ions.	Water	183-188	nuclear RNA export factor 1	Homo sapiens	179-182
19461889-3	2009	Esb1 mutants, characterized by increased root suberin, were found to have reduced day time transpiration rates and increased water-use efficiency during their vegetative growth period.	Water	125-130	Disease resistance-responsive (dirigent-like protein) family protein	Arabidopsis thaliana	0-4
187115-1	1976	A method is described for the efficient concentration of viruses from large volumes of tap water in relatively short time periods.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
19403703-4	2009	We show that osmotic water flux in AQP4-expressing Xenopus laevis oocytes is reduced by extracellular bumetanide (&gt; or =100 microM).	Water	21-26	aquaporin 4 L homeolog	Xenopus laevis	35-39
187115-2	1976	Virus in acidified tap water in the presence of aluminum chloride is adsorbed to a 10-inch (ca.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
187115-4	1976	This filter series is capable of efficiently adsorbing virus from greater than 19,000 liters (5,000 gallons) of treated tap water.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
19401989-3	2009	Tap water is readily available, safe, and effective and, thus, the preferred irrigation fluid.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
19137603-0	2009	Conformational preferences of a short Aib/Ala-based water-soluble peptide as a function of temperature.	Water	52-57	ANIB1	Homo sapiens	38-41
187115-7	1976	Using this procedure, viruses in 1,900 liters (500 gallons) of tap water can be concentrated 100,000-fold in 3 h with an average recovery of 40 to 50%.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
1248451-3	1976	Intraventricular injection of hog renin in a dose of 0.1 Goldblatt unit produced a marked decrease in urine flow which was associated with a decrease in free water clearance and an increase in urinary osmolatiy with no change in osmolar clearance.	Water	158-163	renin	Canis lupus familiaris	34-39
19137603-3	2009	To characterize helical and unfolded states adopted by water-soluble Aib-containing peptides, the conformational preference of Ac-Ala-Aib-Ala-Lys-Ala-Aib-Lys-Ala-Lys-Ala-Aib-Tyr-NH(2) was determined by CD, NMR and MD simulations as a function of temperature.	Water	55-60	ANIB1	Homo sapiens	69-72
19137603-3	2009	To characterize helical and unfolded states adopted by water-soluble Aib-containing peptides, the conformational preference of Ac-Ala-Aib-Ala-Lys-Ala-Aib-Lys-Ala-Lys-Ala-Aib-Tyr-NH(2) was determined by CD, NMR and MD simulations as a function of temperature.	Water	55-60	ANIB1	Homo sapiens	134-137
19137603-3	2009	To characterize helical and unfolded states adopted by water-soluble Aib-containing peptides, the conformational preference of Ac-Ala-Aib-Ala-Lys-Ala-Aib-Lys-Ala-Lys-Ala-Aib-Tyr-NH(2) was determined by CD, NMR and MD simulations as a function of temperature.	Water	55-60	ANIB1	Homo sapiens	134-137
19137603-3	2009	To characterize helical and unfolded states adopted by water-soluble Aib-containing peptides, the conformational preference of Ac-Ala-Aib-Ala-Lys-Ala-Aib-Lys-Ala-Lys-Ala-Aib-Tyr-NH(2) was determined by CD, NMR and MD simulations as a function of temperature.	Water	55-60	ANIB1	Homo sapiens	134-137
19137603-8	2009	Our results point towards conformational heterogeneity of water-soluble Aib-based peptide helices and the associated subtleties.	Water	58-63	ANIB1	Homo sapiens	72-75
19430554-10	2009	CONCLUSION: Comano spa-water alone or in combination with phototherapy had beneficial therapeutic effects on patients with psoriasis.	Water	23-28	surfactant protein A2	Homo sapiens	19-22
19439247-1	2009	Several lines of studies have shown the existence of an important inhibitory mechanism for the control of water intake involving adrenergic alpha2A receptors (ADRA2A).	Water	106-111	adrenoceptor alpha 2A	Homo sapiens	159-165
139972-3	1976	This diuretic action was accompanied by the reduction of the renin hypersecretion elicited by water deprivation.	Water	94-99	renin	Canis lupus familiaris	61-66
19343246-1	2009	Four cyclic pentapeptides and two cyclic heptapeptides modelled on the 3(10) helical Pro138-Gly144 segment of the water channel aquaporin-4 (AQP4) postulated to mediate adhesive interactions between AQP4 tetramers were synthesised by olefin metathesis.	Water	114-119	aquaporin 4	Homo sapiens	128-139
19343246-1	2009	Four cyclic pentapeptides and two cyclic heptapeptides modelled on the 3(10) helical Pro138-Gly144 segment of the water channel aquaporin-4 (AQP4) postulated to mediate adhesive interactions between AQP4 tetramers were synthesised by olefin metathesis.	Water	114-119	aquaporin 4	Homo sapiens	141-145
19487996-4	2009	Concentrations of radon in tap water were up to nearly three-fold the recommended limit.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
19445480-1	2009	Aquaporin-4 (AQP4) is a water channel found at high concentrations around blood vessels in the brain and is organized into elaborate assemblies called square arrays.	Water	24-29	aquaporin 4	Homo sapiens	0-11
19445480-1	2009	Aquaporin-4 (AQP4) is a water channel found at high concentrations around blood vessels in the brain and is organized into elaborate assemblies called square arrays.	Water	24-29	aquaporin 4	Homo sapiens	13-17
19777800-0	2009	Comparative study of c-Fos expression in rat dorsal vagal complex and nucleus ambiguus induced by different durations of restraint water-immersion stress.	Water	131-136	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-26
3242-3	1975	From these measurements, the various water spaces are calculated: total water (ET) and extracellular fluids (LEC), also exchangeable electrolytes: sodium (NaE), potassium (KE), chlorine (ClE) and derived values.	Water	37-42	C-C motif chemokine ligand 16	Homo sapiens	109-112
19954078-5	2009	The diarrhea cases were distributed among all country groups who has used tap water A and the attack rate was ranged from 5.21% (20/384) to 21.23% (100/471).	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
19230825-8	2009	Interestingly, AQP-4 expression was increased in the penumbra of TET-1 brain following transient MCAO leading to the water accumulation.	Water	117-122	aquaporin 4	Mus musculus	15-20
1156576-11	1975	Exhaustive incubation of the tritiated malate (3-H/14-C = 1.95) with fumarase to labilize the pro-R hydrogen at C-3 resulted in release of 65% of the tritium into water.	Water	163-168	fumarate hydratase	Homo sapiens	69-77
19146830-4	2009	Incubation of MDCK cells in hypertonic NaCl medium (500 mOsm/kg H2O) caused fully translocation of TonEBP/NFAT5 from cytoplasm to nucleoplasm and significantly increased COX2 mRNA, protein and activity levels.	Water	64-67	nuclear factor of activated T cells 5	Canis lupus familiaris	106-111
19435367-0	2009	Versatile Pd(OTf)2 x 2 H2O-catalyzed ortho-fluorination using NMP as a promoter.	Water	23-26	POU class 2 homeobox 2	Homo sapiens	0-18
18849021-8	2009	The effect of chronic stress on the severity of Abeta-induced spatial learning and memory impairment was tested by three approaches: behavioral testing in the radial arm water maze, in vivo electrophysiological recording in anesthetized rat, and immunoblot analysis to determine protein levels of learning- and memory-related molecules.	Water	170-175	amyloid beta precursor protein	Rattus norvegicus	48-53
1156576-11	1975	Exhaustive incubation of the tritiated malate (3-H/14-C = 1.95) with fumarase to labilize the pro-R hydrogen at C-3 resulted in release of 65% of the tritium into water.	Water	163-168	complement C3	Homo sapiens	112-115
1178761-3	1975	densitometric method for the simultaneous determination of the water-soluble vitamins B1, B2, B6, and B12 is proposed.	Water	63-68	immunoglobulin kappa variable 5-2	Homo sapiens	77-96
19414254-2	2009	The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds.	Water	69-74	casein kinase 2 alpha 2	Homo sapiens	23-31
238569-9	1975	The exchange from the coil form with water is catalyzed by 0.1 M phosphate with a rate constant kHPO2-/4 = 0.2 times 10(6) 1. mol-1 sec-1.	Water	37-42	secretory blood group 1, pseudogene	Homo sapiens	132-137
19529756-5	2009	Nevertheless, functional assays show that Aqy1 has appreciable water transport activity that aids survival during rapid freezing of P. pastoris.	Water	63-68	Aqy1p	Saccharomyces cerevisiae S288C	42-46
19529756-6	2009	These findings establish that Aqy1 is a gated water channel.	Water	46-51	Aqy1p	Saccharomyces cerevisiae S288C	30-34
240691-1	1975	When chicken breast muscle was homogenized in water, approximately 86% of the glyceraldehyde-3-phosphate dehydrogenase was associated with the particulate fraction.	Water	46-51	glyceraldehyde-3-phosphate dehydrogenase	Gallus gallus	78-118
19606593-6	2009	The delta18O values for the water of nearly all samples of diesel was close to the delta18O of local tap water at the filling station.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	101-104
19606593-6	2009	The delta18O values for the water of nearly all samples of diesel was close to the delta18O of local tap water at the filling station.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
803870-11	1975	Increased tyrosinase activity occurred after storing the homogenate at 0-4degree, removing of supernatant from the homogenate sediment, and washing the 144,000 x g particulate fraction, which suggested the presence of water-soluble, loosely bound inhibitor (s) in the soluble fraction of partially melanotic melanoma.	Water	218-223	tyrosinase	Homo sapiens	10-20
19558100-8	2009	Phosphorus tended to release under river water than tap water.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
803783-4	1975	The oxytocin should be given only in Ringers lactate or, alternately, in Ringers lactate and a 5 per cent dextrose and water solutions.	Water	119-124	oxytocin/neurophysin I prepropeptide	Homo sapiens	4-12
19442267-8	2009	RESULTS: Seventy percent ethanol-water extracts of ginseng significantly inhibited the transcription and secretion of CXCL-10 following TNF-alpha stimulation.	Water	33-38	C-X-C motif chemokine ligand 10	Homo sapiens	118-125
1054766-6	1975	As humidifying fluid only sterile water, possibly fresh tap water, are recommended.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
19426499-15	2009	Water deficit increased the transcript abundance of lipoxygenase and hydroperoxide lyase in fatty metabolism, a pathway known to affect berry and wine aromas.	Water	0-5	lipoxygenase	Vitis vinifera	52-64
4695691-2	1973	Fourteen out of 96 "overnight" tap water samples from five soft water and five hard water towns in England and Wales and from Glasgow (soft water) had lead concentrations of over 0.1 p.p.m.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
19383790-1	2009	Aquaporin (AQP) 4 is the predominant water channel in the mammalian brain, abundantly expressed in the blood-brain and brain-cerebrospinal fluid interfaces of glial cells.	Water	37-42	aquaporin 4	Homo sapiens	0-17
19137573-5	2009	The self-association of tropoelastin at pH 11 is due to hydrophobic interactions in an emulsion-like system in which the spherules coalesce in a manner like a water-based latex paint that forms a durable hydrophobic sheet as water and the organic solvent evaporate.	Water	159-164	elastin	Homo sapiens	24-36
19137573-5	2009	The self-association of tropoelastin at pH 11 is due to hydrophobic interactions in an emulsion-like system in which the spherules coalesce in a manner like a water-based latex paint that forms a durable hydrophobic sheet as water and the organic solvent evaporate.	Water	225-230	elastin	Homo sapiens	24-36
19569498-0	2009	[Spin isomeric selectivity of water molecules upon DNA hydration].	Water	30-35	spindlin 1	Homo sapiens	1-5
19569498-2	2009	It was shown that the concentration of quasi-free molecules that form the rotational spectrum of spin isomers increases considerably in the hydrational shell of the DNA molecule as compared to pure water.	Water	198-203	spindlin 1	Homo sapiens	97-101
19569498-6	2009	The data obtained allowed us to assume that the stability of different biologically important states of macromolecules can be changed by varying the relative concentration of water spin isomers in solution.	Water	175-180	spindlin 1	Homo sapiens	181-185
19387929-1	2009	BACKGROUND: The corrosion of drinking water pipe materials can release different elements into tap water.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	95-98
19387929-1	2009	BACKGROUND: The corrosion of drinking water pipe materials can release different elements into tap water.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
19387929-13	2009	There were remarkable regional differences in the frequency of tap water contamination.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
19216032-6	2009	However, microcystins are present frequently in tap water at lower doses.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
19216032-7	2009	Here, we hypothesized that chronic consume of tap water containing low doses of microcystins may be a risk factor for liver and colorectal cancer.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
19203604-6	2009	The proposed method was validated by simultaneous determination of phosphate and silicate in detergent and tap water and also Co(2+) and Ni(2+) in tap water samples.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
19203604-6	2009	The proposed method was validated by simultaneous determination of phosphate and silicate in detergent and tap water and also Co(2+) and Ni(2+) in tap water samples.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
19305037-1	2009	The most recent electron dosimetry code of practice for radiotherapy written by the Institute of Physics and Engineering in Medicine was published in 2003 and is based on the NPL electron absorbed dose to water calibration service.	Water	205-210	N-acetylneuraminate pyruvate lyase	Homo sapiens	175-178
19305037-2	2009	NPL has calibrated many Scanditronix type NACP-02 and PTW Roos type 34001 parallel plate ionization chambers in terms of absorbed dose to water, for use with the code of practice.	Water	138-143	N-acetylneuraminate pyruvate lyase	Homo sapiens	0-3
26609610-1	2009	In this paper we assess the accuracy of the B3LYP, X3LYP, and newly developed M06-L, M06-2X, and M06 functionals to predict the binding energies of neutral and charged water clusters including (H2O)n, n = 2-8, 20), H3O(+)(H2O)n, n = 1-6, and OH(-)(H2O)n, n = 1-6.	Water	168-173	H3 clustered histone 15	Homo sapiens	215-218
19233231-11	2009	In the intestine, ANP and CNP decrease water and sodium chloride absorption through an increase in cGMP levels.	Water	39-44	natriuretic peptide C	Rattus norvegicus	26-29
18834589-9	2009	Also, 13 species were detected in tap water with concentrations up to 0.13 microgL(-1) for tri(chloropropyl) phosphate (TCPP).	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
19074584-10	2009	MIC-1 production by human adipocytes was stimulated by H(2)O(2) and 15d-prostaglandin J(2).	Water	55-60	growth differentiation factor 15	Homo sapiens	0-5
18951529-1	2009	Aquaporin-4 (Aqp4) is a water transport protein expressed in glia and ependymocytes in brain.	Water	24-29	aquaporin 4	Mus musculus	0-11
18951529-1	2009	Aquaporin-4 (Aqp4) is a water transport protein expressed in glia and ependymocytes in brain.	Water	24-29	aquaporin 4	Mus musculus	13-17
19292492-1	2009	The structures of tetramethylammonium (TMA(+)) and phenyltrimethylammonium (PTMA(+)) with 1-8 water molecules attached were investigated using infrared photodissociation spectroscopy (IRPD), blackbody infrared radiative dissociation, and theory to elucidate the effects of ion-water interactions and water-water hydrogen bonding in clusters containing these hydrophobic ions.	Water	94-99	prothymosin alpha	Homo sapiens	76-80
19200549-7	2009	A cyclohexyldiol-silica fiber was used, as a simple example of applicability, for the successful determination of benzaldehyde, acetophenone and dimethylphenol at trace level in spiked tap water.	Water	189-194	nuclear RNA export factor 1	Homo sapiens	185-188
19179356-0	2009	"Double water exclusion": a hypothesis refining the O-ring theory for the hot spots at protein interfaces.	Water	8-13	alcohol dehydrogenase iron containing 1	Homo sapiens	74-77
19179356-2	2009	As this ring of residues is served to occlude water molecules from the hot spot, the O-ring theory is also called "water exclusion" hypothesis.	Water	46-51	alcohol dehydrogenase iron containing 1	Homo sapiens	71-74
19179356-2	2009	As this ring of residues is served to occlude water molecules from the hot spot, the O-ring theory is also called "water exclusion" hypothesis.	Water	115-120	alcohol dehydrogenase iron containing 1	Homo sapiens	71-74
19179356-3	2009	We propose a "double water exclusion" hypothesis to refine the O-ring theory by assuming the hot spot itself is water-free.	Water	21-26	alcohol dehydrogenase iron containing 1	Homo sapiens	93-96
19179356-3	2009	We propose a "double water exclusion" hypothesis to refine the O-ring theory by assuming the hot spot itself is water-free.	Water	112-117	alcohol dehydrogenase iron containing 1	Homo sapiens	93-96
19179356-4	2009	To computationally model a water-free hot spot, we use a biclique pattern that is defined as two maximal groups of residues from two chains in a protein complex holding the property that every residue contacts with all residues in the other group.	Water	27-32	alcohol dehydrogenase iron containing 1	Homo sapiens	38-41
19199480-3	2009	Water-solubilizing groups could be installed conveniently at either the C-2 or C-3 position of the imidazo[1,2-b]thiazole ring.	Water	0-5	complement component 2 (within H-2S)	Mus musculus	72-75
19437773-2	2009	Here we show that alcohol dehydrogenase (ADH) has high affinity toward a negatively charged phospholipid, dimyristoylphosphatidic acid (DMPA), which forms a Langmuir monolayer at an air-water interface.	Water	186-191	aldo-keto reductase family 1 member A1	Homo sapiens	18-39
19437773-2	2009	Here we show that alcohol dehydrogenase (ADH) has high affinity toward a negatively charged phospholipid, dimyristoylphosphatidic acid (DMPA), which forms a Langmuir monolayer at an air-water interface.	Water	186-191	aldo-keto reductase family 1 member A1	Homo sapiens	41-44
19437773-3	2009	Incorporation of ADH into the DMPA monolayer was monitored with surface pressure measurements and polarization-modulation infrared reflection absorption spectroscopy, with the alpha-helices from ADH being mainly oriented parallel to the water surface.	Water	237-242	aldo-keto reductase family 1 member A1	Homo sapiens	17-20
19073180-6	2009	Treatment with MMP-9 siRNA produced a significant reduction in the cerebral infarction volume, brain water content, mortality rate and accompanying neurological deficits.	Water	101-106	matrix metallopeptidase 9	Rattus norvegicus	15-20
18335002-1	2009	Volunteer studies suggest that showering/bathing with chlorinated tap water contributes to daily chloroform inhalation exposure for the majority of US adults.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
19089804-4	2009	A conformational analysis by NMR in CD(3)CN/H(2)O mixture has been carried out on the CLA analogue, in which Phe(3) has been replaced by a betaPhe, to study the influence of the mutation on the three-dimensional structure.	Water	44-49	clasper	Mus musculus	86-89
18925386-1	2009	Kappa opioid receptor agonists induce water diuresis in animals and humans.	Water	38-43	opioid receptor kappa 1	Homo sapiens	0-21
19290661-2	2009	One of the most powerful approaches to measure local water dynamics within 5 A distances is to utilize the modulation of the nuclear spin relaxation rate of water protons through their time-dependent dipolar coupling to paramagnetic probes, here nitroxide spin labels.	Water	53-58	spindlin 1	Homo sapiens	133-137
19290661-2	2009	One of the most powerful approaches to measure local water dynamics within 5 A distances is to utilize the modulation of the nuclear spin relaxation rate of water protons through their time-dependent dipolar coupling to paramagnetic probes, here nitroxide spin labels.	Water	53-58	spindlin 1	Homo sapiens	256-260
19290661-2	2009	One of the most powerful approaches to measure local water dynamics within 5 A distances is to utilize the modulation of the nuclear spin relaxation rate of water protons through their time-dependent dipolar coupling to paramagnetic probes, here nitroxide spin labels.	Water	157-162	spindlin 1	Homo sapiens	133-137
19290661-2	2009	One of the most powerful approaches to measure local water dynamics within 5 A distances is to utilize the modulation of the nuclear spin relaxation rate of water protons through their time-dependent dipolar coupling to paramagnetic probes, here nitroxide spin labels.	Water	157-162	spindlin 1	Homo sapiens	256-260
19621569-11	2009	Meanwhile, experiments have demonstrated HvPIP2;1, one of barley aquaporins, has a higher water and CO2 transport activity.	Water	90-95	HvPIP2;1	Hordeum vulgare	41-49
4668577-0	1972	Spin-lattice interaction of water and protein membranes in cell metabolism.	Water	28-33	spindlin 1	Homo sapiens	0-4
19237699-4	2009	We also tested for the aquaporin-4 (AQP4) water channel autoantibody (NMO-IgG) in 14 patients from an independently ascertained cohort of individuals with PRES.	Water	42-47	aquaporin 4	Homo sapiens	23-34
19237699-4	2009	We also tested for the aquaporin-4 (AQP4) water channel autoantibody (NMO-IgG) in 14 patients from an independently ascertained cohort of individuals with PRES.	Water	42-47	aquaporin 4	Homo sapiens	36-40
5016604-0	1972	Preparation and properties of active water insoluble derivatives of adenosine deaminase.	Water	37-42	adenosine deaminase	Homo sapiens	68-87
19201900-7	2009	Moreover, H(2)O(2) reversed ADAM17 inhibition by DTT.	Water	10-15	ADAM metallopeptidase domain 17	Homo sapiens	28-34
5122510-0	1971	Radiostrontium in tap water, July-December 1970.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
19402519-2	2009	This review aims to elucidate that besides microbial metabolism product such as geosmin and 2-MIB, organic anaerobic decomposition product such as thiol-thioether were also main odorant in drinking water of China.	Water	198-203	MIB E3 ubiquitin protein ligase 1	Homo sapiens	94-97
5538905-0	1971	Acute water retention associated with continuous slow infusion of oxytocin.	Water	6-11	oxytocin/neurophysin I prepropeptide	Homo sapiens	66-74
19131070-2	2009	The method is based on solid-phase extraction (SPE) of 400mL water using Oasis HLB (Waters) adsorber material, followed by negative electrospray ionization (ESI) triple quadrupole LC-MS-MS detection.	Water	61-66	cAMP responsive element binding protein 3 like 1	Homo sapiens	73-78
19461869-5	2009	In this work, we perform a set of molecular mechanics (MM) Poisson-Boltzmann (PB) surface area (SA) calculations on the wild type and two mutant TCR-SEC3 systems and show that the method is able to discriminate between weak and strong binders only when key explicit water molecules are included in the analysis.	Water	266-271	exocyst complex component 1	Homo sapiens	149-153
5523836-0	1970	[Preparation of tap-water for irrigation in urology].	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
19070604-2	2009	Aquaporins, particularly aquaporin 4 (Aqp4), are membrane proteins with important roles in water and ion flux across cell membranes, including cells of the inner ear and pathways of the brain used for hearing.	Water	91-96	aquaporin 4	Mus musculus	25-36
5414230-0	1970	Natriuretic effect of alpha-MSH in the water-loaded rat.	Water	39-44	proopiomelanocortin	Rattus norvegicus	22-31
19946467-5	2009	When subjected to mild water restriction, 3 month old Ku86(-/-), but not Ku86(+/+),mice rapidly become dehydrated as evidenced by decrease in body weight, increased production of antidiuretic hormone,increased urine osmolality and decreased urine volume.	Water	23-28	X-ray repair complementing defective repair in Chinese hamster cells 5	Mus musculus	54-58
5379483-0	1969	[Hygienic characteristics of organic admixtures in tap water].	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
19119014-5	2009	Examining the four X-ray crystal structures of their CA II adducts, we observed several (2-3) active site water molecules interacting with the chlorthalidone, trichloromethiazide, and furosemide scaffolds which may be responsible for this important difference of activity.	Water	106-111	carbonic anhydrase 2	Homo sapiens	53-58
19119014-7	2009	Chlorthalidone bound within the CA II active site is in an enolic (lactimic) tautomeric form, with the enolic OH also participating in two strong hydrogen bonds with Asn67 and a water molecule.	Water	178-183	carbonic anhydrase 2	Homo sapiens	32-37
4239805-0	1969	[Use of water-insoluble derivatives of the trypsin-kallikrein inhibitor for the isolation of kallikrein and plasmin].	Water	8-13	kallikrein related peptidase 4	Homo sapiens	51-61
19191369-0	2009	Production of vibrationally excited H(2)O from charge exchange of H(3)O(+) with cesium.	Water	36-41	H3 clustered histone 15	Homo sapiens	66-71
4239805-0	1969	[Use of water-insoluble derivatives of the trypsin-kallikrein inhibitor for the isolation of kallikrein and plasmin].	Water	8-13	kallikrein related peptidase 4	Homo sapiens	93-103
5782162-0	1969	The effect of radon inhalation at Swieradow-Spa on the water and electrolyte balance in arterial hypertension.	Water	55-60	surfactant protein A2	Homo sapiens	44-47
18805556-2	2009	Increasing evidence from immunological and histopathological studies suggests that LETM is an autoimmune disorder caused by pathogenic antibodies to aquaporin-4 (AQP4-Ab), the most abundant water channel in the CNS, at least in a subset of patients.	Water	190-195	aquaporin 4	Homo sapiens	149-160
18805556-2	2009	Increasing evidence from immunological and histopathological studies suggests that LETM is an autoimmune disorder caused by pathogenic antibodies to aquaporin-4 (AQP4-Ab), the most abundant water channel in the CNS, at least in a subset of patients.	Water	190-195	aquaporin 4	Homo sapiens	162-166
5686206-0	1968	[Acquired methemoglobinemia in infants due to tap water].	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
19124740-7	2009	Surprisingly, activation of the CD25-depleted betagalTCR T cells before transfer into the lymphopenic recipients reduced EAU.	Water	121-124	interleukin 2 receptor, alpha chain	Mus musculus	32-36
6007988-0	1966	[Kinetics of the formation of water-soluble derivatives of estrogen-4-C 14 in presence of rat liver, ovary and kidney homogenates].	Water	30-35	anti-Mullerian hormone receptor type 2	Rattus norvegicus	59-74
19062029-7	2009	The recoveries of N-nitrosodimethylamine, N-nitrosomorpholine, N-nitrosomethylethylamine, and N-nitrosopyrrolidine present in tap water sample at a concentration of 10 ng/L (mean+/-standard deviation, n=4) were (94.8+/-2.7)%, (102.0+/-6.9)%, (99.3+/-3.9)%, and (102.8+/-2.5)%, respectively.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
19127436-8	2009	While they selectively dissolved in gastric-like medium, in tap water (intake conditions), the matrix remained almost unchanged and efficiently prevented drug dissolution.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
5927523-0	1966	Prolactin and serum osmolality of hypophysectomized killifish, Fundulus heteroclitus, in fresh-water.	Water	95-100	prolactin	Fundulus heteroclitus	0-9
19697963-4	2009	This review considers how knowledge of CFTR structure and function and its role in transepithelial salt and water movements provides insight into the mechanism of action of CFTR inhibitors.	Water	108-113	cystic fibrosis transmembrane conductance regulator	Mus musculus	39-43
19697963-4	2009	This review considers how knowledge of CFTR structure and function and its role in transepithelial salt and water movements provides insight into the mechanism of action of CFTR inhibitors.	Water	108-113	cystic fibrosis transmembrane conductance regulator	Mus musculus	173-177
4226365-0	1965	[Effect of the mineral water (source 2) of the health resort Dzhalal-Abad on the secretory function of the stomach in gastritis with various acidity levels].	Water	23-28	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	69-73
19035614-0	2009	Syntheses of high-valent fac-[99mTcO3]+ complexes and [3+2] cycloadditions with alkenes in water as a direct labelling strategy.	Water	91-96	cytochrome c oxidase III, mitochondrial	Mus musculus	32-37
14196398-0	1964	WATER RETENTION DUE TO OXYTOCIN.	Water	0-5	oxytocin/neurophysin I prepropeptide	Homo sapiens	23-31
20198279-0	2009	[Efficacy of mud-bath therapy with Mineral Water from the Sillene spring at Italy"s Chianciano Spa for osteoarthritis of the knee: a clinical statistical study].	Water	43-48	surfactant protein A2	Homo sapiens	95-98
20198279-2	2009	Our study evalues the efficacy of mud-bath therapy with mineral water from the Sillene Spring at Italy"s Chianciano Spa in patients with osteoarthritis of the knee.	Water	64-69	surfactant protein A2	Homo sapiens	116-119
19193936-7	2009	Functional expression in Xenopus laevis oocytes showed that FhaAqp1a was a water-selective channel, whereas FhAqp3 was permeable to water, glycerol, and urea.	Water	132-137	aquaporin-3a	Fundulus heteroclitus	108-114
19193936-12	2009	The reduced synthesis of FhAqp3 may be one of these mechanisms to regulate water and/or solute transport in the embryo.	Water	75-80	aquaporin-3a	Fundulus heteroclitus	25-31
14242670-0	1964	[EFFECT OF VRNICI SPA WARM MINERAL WATER ON GALLBLADDER MOTILITY].	Water	35-40	surfactant protein A2	Homo sapiens	18-21
19275147-3	2009	Multivariate calibration was used to derive a quantitative relationship between the measured relative response factor (RRF) of polar metabolites with respect to four physicochemical properties associated with ion evaporation in ESI-MS, namely, molecular volume (MV), octanol-water distribution coefficient (log D), absolute mobility (mu(o)), and effective charge (z(eff)).	Water	275-280	mitochondrial ribosome recycling factor	Homo sapiens	119-122
19821985-4	2009	The methemoglobin fraction increased to 5.9 (1.3; 8.4) % with a maximal value of 12.2% on the days of water disinfection (P &lt; 0.001 compared to disinfection-free days).	Water	102-107	hemoglobin subunit gamma 2	Homo sapiens	4-17
22059353-8	2009	Source of drinking water with a strong association with drinking tap water was the only factor significantly associated with seropositivity to cryptosporidiosis infection (OR= 37.33, P&lt; 0.001).	Water	19-24	nuclear RNA export factor 1	Homo sapiens	65-68
19304108-3	2009	The patient was unaware that he was wearing a bandage contact lens and repeatedly rinsed his face and eyelids with tap water.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
22059353-8	2009	Source of drinking water with a strong association with drinking tap water was the only factor significantly associated with seropositivity to cryptosporidiosis infection (OR= 37.33, P&lt; 0.001).	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
14186887-1	1964	SAPONIFICATION STUDY OF WATER-SOLUBLE NEUTRAL FATS].	Water	24-29	chromosome 10 open reading frame 90	Homo sapiens	46-50
19096775-4	2009	This permits water entry into the cells and water exit through AQP3 and AQP4.	Water	13-18	aquaporin 4	Homo sapiens	72-76
19096775-4	2009	This permits water entry into the cells and water exit through AQP3 and AQP4.	Water	44-49	aquaporin 4	Homo sapiens	72-76
19209385-1	2009	Aquaporin4 (AQP4) has an important role in water homeostasis of human brain and a dysfunction of AQP4 could induce pathological conditions in neuronal activity.	Water	43-48	aquaporin 4	Homo sapiens	0-10
19209385-1	2009	Aquaporin4 (AQP4) has an important role in water homeostasis of human brain and a dysfunction of AQP4 could induce pathological conditions in neuronal activity.	Water	43-48	aquaporin 4	Homo sapiens	12-16
14463785-0	1961	Effect of oxytocin, vasopressin, and other disulfide hormones on uptake and extrusion of water by mitochondria.	Water	89-94	oxytocin/neurophysin I prepropeptide	Homo sapiens	10-18
19082572-1	2009	In nautical literature, "dead-water" refers to the obstructive effect encountered by ships moving in stratified water due to the ship generating waves on an interface that separates different water masses.	Water	30-35	inositol polyphosphate-5-phosphatase D	Homo sapiens	85-89
19082572-1	2009	In nautical literature, "dead-water" refers to the obstructive effect encountered by ships moving in stratified water due to the ship generating waves on an interface that separates different water masses.	Water	112-117	inositol polyphosphate-5-phosphatase D	Homo sapiens	85-89
19082572-1	2009	In nautical literature, "dead-water" refers to the obstructive effect encountered by ships moving in stratified water due to the ship generating waves on an interface that separates different water masses.	Water	112-117	inositol polyphosphate-5-phosphatase D	Homo sapiens	85-89
20224238-0	2009	Effects of natural point mutation of rat aquaporin 5 expressed in vitro on its capacity of water permeability and membrane trafficking.	Water	91-96	aquaporin 5	Rattus norvegicus	41-52
19785868-9	2009	It is important to irrigate with safe tap water at a temperature of around 37 degrees C. Most patients treated in this way feel safe to go out again.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
14483320-0	1961	[The influence of a mineral water on the utilization of fats in artificially fed infants].	Water	28-33	chromosome 10 open reading frame 90	Homo sapiens	56-60
18938210-8	2008	The treatment of the animal with HGF suppressed the increases in water and sodium and calcium ion contents, but not the decreases in potassium and magnesium ion contents.	Water	65-70	hepatocyte growth factor	Rattus norvegicus	33-36
19159772-3	2009	The method is used to determine HMX and RDX concentrations in ground water samples from a military site.	Water	69-74	radixin	Homo sapiens	40-43
19022253-0	2008	AtTIP1;3 and AtTIP5;1, the only highly expressed Arabidopsis pollen-specific aquaporins, transport water and urea.	Water	99-104	Ankyrin repeat family protein with DHHC zinc finger domain-containing protein	Arabidopsis thaliana	0-6
13763653-0	1961	A practical method for culturing coccidial oocysts in tap water.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
19022253-0	2008	AtTIP1;3 and AtTIP5;1, the only highly expressed Arabidopsis pollen-specific aquaporins, transport water and urea.	Water	99-104	tonoplast intrinsic protein 5;1	Arabidopsis thaliana	13-21
19022253-4	2008	When characterized using Xenopus oocyte swelling assays, AtTIP1;3 and AtTIP5;1 showed intermediate water permeabilities.	Water	99-104	Ankyrin repeat family protein with DHHC zinc finger domain-containing protein	Arabidopsis thaliana	57-63
19022253-4	2008	When characterized using Xenopus oocyte swelling assays, AtTIP1;3 and AtTIP5;1 showed intermediate water permeabilities.	Water	99-104	tonoplast intrinsic protein 5;1	Arabidopsis thaliana	70-78
19022253-6	2008	In conclusion, these results suggest a function for AtTIP1;3 and AtTIP5;1 as specific water and urea channels in Arabidopsis pollen.	Water	86-91	tonoplast intrinsic protein 5;1	Arabidopsis thaliana	65-73
19123781-2	2009	In this reaction, the utilization of HOAc as a solvent leads to 3-pyrimidin-5-ylpropanamides, whereas water as reaction media results in the spiro[5.5]undecane-1,5,9-triones from same starting materials.	Water	102-107	hypoacusis 2 (autosomal recessive)	Homo sapiens	37-41
19120059-11	2009	Combined IL-15 and IL-15R alpha treatment decreased apoptosis of NK cells from alcohol-consuming mice to levels similar to untreated water-drinking mice and greatly increased the percentage and number of NK cells in both the spleen and BM.	Water	133-138	interleukin 15	Mus musculus	9-14
13744384-0	1960	[Importance of the knowledge of the body water content for the determination of fats in the carcass and the biological value of proteins].	Water	41-46	chromosome 10 open reading frame 90	Homo sapiens	80-84
18975953-0	2008	Synthesis of a new water-soluble oligo(phenylenevinylene) containing a tyrosine moiety for tyrosinase activity detection.	Water	19-24	tyrosinase	Homo sapiens	91-101
18975953-1	2008	A new water-soluble oligo(phenylenevinylene) containing a tyrosine unit (OPV-Tyr) was synthesized as a fluorescent probe to optically detect tyrosinase activity.	Water	6-11	tyrosinase	Homo sapiens	141-151
18973310-3	2008	These ionic beta-1,3-glucans wrap around single-walled carbon nanotubes (SWNTs) and double-walled carbon nanotubes (DWNTs) to form water-soluble complexes with ionic groups on their exterior surface.	Water	131-136	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	12-20
13750878-0	1960	[Bactericidal property of iodine in tap water].	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
19018099-6	2008	A water-mediated network can be re-established by introducing the hydrophilic Glu121 inside the cavity, which results in a rigid protein with the alpha2 helix adopting an altered conformation compared with wild-type CRABPII.	Water	2-7	cellular retinoic acid binding protein 2	Homo sapiens	216-223
18776134-4	2009	To test this hypothesis, we characterized the expression of SOCS-1 and downstream apoptosis signal-regulating kinase (ASK)-1-Jun N-terminal kinase signaling molecules in small airway epithelial cells in the presence of H(2)O(2), which induces oxidative stress.	Water	219-224	suppressor of cytokine signaling 1	Mus musculus	60-66
13594017-0	1958	Water intoxication following tap-water enemas.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
19153045-10	2009	This suggests that AQP4 overexpression can lead to abnormal water transport and edema formation in meningiomas.	Water	60-65	aquaporin 4	Homo sapiens	19-23
18952441-6	2008	Tyrosine sulfonate-containing CCR5 peptides exhibited reduced water solubility, limiting their use in assay and probe development.	Water	62-67	C-C motif chemokine receptor 5	Homo sapiens	30-34
13422660-0	1957	[Acid-alcohol resistant non-tuberculous bacilli in tap water].	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
19039818-12	2008	We can conclude that cerebrocrast may regulate food intake and body weight through glucose sensing by proopiomelanocortin (POMC) neurons, that are involved in control of glucose homeostasis, stimulation of alpha-melanocyte-stimulating hormone (alpha-MSH) secretion, activation of MC4-Rs and inhibition of neuropeptide Y (NPY) in the ARC of the hypothalamus, affecting the kidney, and causing decreased urine output and water intake.	Water	419-424	proopiomelanocortin	Rattus norvegicus	102-121
19039818-12	2008	We can conclude that cerebrocrast may regulate food intake and body weight through glucose sensing by proopiomelanocortin (POMC) neurons, that are involved in control of glucose homeostasis, stimulation of alpha-melanocyte-stimulating hormone (alpha-MSH) secretion, activation of MC4-Rs and inhibition of neuropeptide Y (NPY) in the ARC of the hypothalamus, affecting the kidney, and causing decreased urine output and water intake.	Water	419-424	proopiomelanocortin	Rattus norvegicus	123-127
19238474-2	2009	The SLC5A1 gene encodes the Na(+)-glucose cotransporter SGLT1 protein, which not only transports glucose, but also acts as a water channel.	Water	125-130	solute carrier family 5 member 1	Rattus norvegicus	4-10
19238474-2	2009	The SLC5A1 gene encodes the Na(+)-glucose cotransporter SGLT1 protein, which not only transports glucose, but also acts as a water channel.	Water	125-130	solute carrier family 5 member 1	Rattus norvegicus	56-61
19238474-5	2009	Immunohistochemical analysis of parotid gland of diabetic rats revealed that SGLT1 protein expression increased in the luminal membrane of ductal cells, which can stimulate water reabsorption from primary saliva.	Water	173-178	solute carrier family 5 member 1	Rattus norvegicus	77-82
13385813-2	1956	Effect on the pyrogenicity of tap water.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
19459565-3	2009	Thermomineral water of the Niska Banja spa is homeothermic, oligomineral, alkaline, low radioactive radon water and also, in conjunction with mineral peloid, is considered to be optimal for this indication.	Water	14-19	surfactant protein A2	Homo sapiens	39-42
19459565-3	2009	Thermomineral water of the Niska Banja spa is homeothermic, oligomineral, alkaline, low radioactive radon water and also, in conjunction with mineral peloid, is considered to be optimal for this indication.	Water	106-111	surfactant protein A2	Homo sapiens	39-42
18707613-6	2008	Of the 16 samples tested, 6 (38%) were PCR-positive and the concentration of the esp marker ranged between 1.1 x 10(2) and 5.3 x 10(2) gene copies per 100 ml of water samples.	Water	161-166	sperm equatorial segment protein 1	Homo sapiens	81-84
18707613-8	2008	The presence of the esp marker in water samples immediately after storm events not only indicated human faecal pollution but also provided evidence of the degree of human faecal pollution.	Water	34-39	sperm equatorial segment protein 1	Homo sapiens	20-23
13362229-0	1956	Detection of cysts of Endamoeba histolytica in tap water by the use of membrane filter.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
18757507-4	2008	METHODS: EAU was induced in B10.RIII mice by immunization with the peptide RBP-3(161-180).	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	75-80
19366470-6	2009	Recent studies of water transport and the spatial buffering of K+ through glial cells have highlighted the involvement of both AQP4 and Kir channels in regulating the extracellular environment in the brain and retina.	Water	18-23	aquaporin 4	Homo sapiens	127-131
13059983-0	1953	[Results of thermal therapy with Eaux-Bonnes spa water].	Water	49-54	surfactant protein A2	Homo sapiens	45-48
20490369-1	2009	A recently proposed electronic structure-based force field called the explicit polarization (X-Pol) potential is used to study many-body electronic polarization effects in a protein, in particular by carrying out a molecular dynamics (MD) simulation of bovine pancreatic trypsin inhibitor (BPTI) in water with periodic boundary conditions.	Water	299-304	spleen trypsin inhibitor I	Bos taurus	253-288
19402494-1	2009	Organic matter in the tap water was isolated into strongly hydrophobic acids, weakly hydrophobic acids, charged hydrophilic and neutral hydrophilic by DAX-8, XAD-4 and IRA-958 synthetic resins.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
19070604-2	2009	Aquaporins, particularly aquaporin 4 (Aqp4), are membrane proteins with important roles in water and ion flux across cell membranes, including cells of the inner ear and pathways of the brain used for hearing.	Water	91-96	aquaporin 4	Mus musculus	38-42
18832438-5	2008	Compared with wild-type mice, however, renin and angiotensin II were dramatically upregulated in the kidney and brain of VDR-null mice, leading to a marked increase in water intake and salt appetite.	Water	168-173	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	121-124
18832438-7	2008	In the brain of VDR-null mice, expression of c-Fos, which is known to associate with increased water intake, was increased in the hypothalamic paraventricular nucleus and the subfornical organ.	Water	95-100	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	16-19
18832438-9	2008	Furthermore, despite a salt-deficient diet to reduce intestinal salt absorption, VDR-null mice still maintained the increased water intake and urinary output.	Water	126-131	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	81-84
18986671-4	2008	Oxidation of TCEP results in both H+ and Cl(-) release, while the TBP mineralization pathway results in CO2, H2O, H+, and PO4(3-).	Water	109-112	TATA-box binding protein	Homo sapiens	66-69
19599518-0	1910	Note on an Organism Isolated from Washington Tap Water, Aggluginated Readily by the Serum of Typhoid Fever Patients.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
19180911-7	2008	CONCLUSION: Vasopressin may down-regulate the expression of AQP7 mRNA in the endolymphatic sac and induce a decreased absorption of endolymph, which decreases the water permeability in the potassium ions recycle pathway in the organ of Corti and disturbs the circulation of endolymph, resulting in endolymphatic hydrops.	Water	163-168	aquaporin 7	Rattus norvegicus	60-64
33780673-12	2021	The microkinetic analysis indicates that there are four steps controlling the reaction cycle: CH2Cl2* + *   CH2Cl* + Cl*, CH2OCl* + Cl*   CH2O* + Cl*, O2* + *   2O*, and CHO2* + OH*   CO2 + H2O*.	Water	123-126	EBP cholestenol delta-isomerase	Homo sapiens	170-174
18855413-7	2008	0603 log m H2 The experimental results indicate that the Au-YSZ/HgO/Hg cell can be used to measure the solubility of H2 in aqueous fluid at temperatures and pressures near to the critical state of water.	Water	197-202	homogentisate 1,2-dioxygenase	Homo sapiens	64-67
19074436-4	2009	Melittin, a water-soluble 26-amino acid peptide derived from bee venom of Apis mellifera, can exert toxic or inhibitory effects on many types of tumor cells.	Water	12-17	melittin	Apis mellifera	0-8
19164545-3	2009	Recent studies from our laboratory have shown that glutamate, acting on group I metabotropic glutamate receptors (mGluRs), increases the permeability of astrocyte AQP4, which, in situations of hypoxia-ischemia, will increase astrocyte water uptake.	Water	235-240	aquaporin 4	Mus musculus	163-167
19164545-8	2009	In support of this conclusion we found that EPO reduced the neurological symptoms in a mouse model of primary brain edema known to depend upon AQP4 water transport.	Water	148-153	aquaporin 4	Mus musculus	143-147
33652280-1	2021	Aluminum (Al) release and deposition in drinking water distribution systems (DWDS) are highly detrimental to tap water quality.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	109-112
18936104-0	2009	Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat.	Water	119-124	cannabinoid receptor 1	Rattus norvegicus	61-64
19526097-1	2008	Were studied the effects of water-soluble plant polysaccharides isolated from pharmacopoeic raw material on anaphylactic shock and production of IgE and IgG1 by lymphocytes from mice immunized with ovalbumin.	Water	28-33	LOC105243590	Mus musculus	153-157
33652280-1	2021	Aluminum (Al) release and deposition in drinking water distribution systems (DWDS) are highly detrimental to tap water quality.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
33652280-3	2021	The two cities were selected based on the wide disparity reported in pH and turbidity in the finished and tap water qualities, with higher fluctuation of pH (average 8.0) and turbidity (average 0.78 NTU) reported in the northern and southern cities, respectively.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	106-109
19226702-3	2009	METHODS: sEH inhibition was achieved using 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (25 mg/l) and cis- 4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (5 mg/l) administered via drinking water starting 3 days prior to monocrotaline injection (60 mg/kg).	Water	201-206	epoxide hydrolase 2	Rattus norvegicus	9-12
19031895-6	2008	Respective percent frequency for the esp(fs/fm) and esp(fm) was 36 and 14% in lake water, 38.8 and 2.3% in stream water, 24 and 6.3% in nearshore sand; 0% in backshore sand; 24.4 and 0% in Cladophora sp.	Water	83-88	sperm equatorial segment protein 1	Homo sapiens	1-4
32967435-2	2021	The results showed that the protein, ash, dietary fiber, water holding capacity, and water solubility of fractionated potato residue were decreased with decreasing particle size, while the starch, fat, polyphenols, and alpha-amylase activity inhibition ratio were increased.	Water	57-62	alpha-amylase	Solanum tuberosum	219-232
19031895-6	2008	Respective percent frequency for the esp(fs/fm) and esp(fm) was 36 and 14% in lake water, 38.8 and 2.3% in stream water, 24 and 6.3% in nearshore sand; 0% in backshore sand; 24.4 and 0% in Cladophora sp.	Water	83-88	sperm equatorial segment protein 1	Homo sapiens	37-40
19031895-6	2008	Respective percent frequency for the esp(fs/fm) and esp(fm) was 36 and 14% in lake water, 38.8 and 2.3% in stream water, 24 and 6.3% in nearshore sand; 0% in backshore sand; 24.4 and 0% in Cladophora sp.	Water	114-119	sperm equatorial segment protein 1	Homo sapiens	1-4
19031895-6	2008	Respective percent frequency for the esp(fs/fm) and esp(fm) was 36 and 14% in lake water, 38.8 and 2.3% in stream water, 24 and 6.3% in nearshore sand; 0% in backshore sand; 24.4 and 0% in Cladophora sp.	Water	114-119	sperm equatorial segment protein 1	Homo sapiens	37-40
19076266-1	2009	The central administration of apelin, a recently identified adipokine, has been shown to affect food and water intake.	Water	105-110	apelin	Rattus norvegicus	30-36
19076266-6	2009	Intracerebroventricular administration of apelin-13 decreased food and water intake and respiratory exchange ratio in DIO rats on the control diet, but had no effect in DIO rats on the high-fat diet.	Water	71-76	apelin	Rattus norvegicus	42-48
33957193-0	2021	Arsenic exposure in drinking water reduces Lgr5 and secretory cell marker gene expression in mouse intestines.	Water	29-34	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	43-47
19885024-1	2009	Anti-inflammatory factor (AIF) is a water soluble extract of three herbs, Panax notoginseng (Burk.)	Water	36-41	apoptosis inducing factor mitochondria associated 1	Homo sapiens	26-29
18671764-3	2008	OBJECTIVE: To investigate water distribution through the lower lip surface.	Water	26-31	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	63-66
33736143-7	2021	The concentration in the first flush water tended to decrease with time since the tap installation, and this was significant after 10 years for nickel but not significant for lead.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	82-85
18846302-0	2008	Isotope exchange and structural rearrangements in reactions between size-selected ionic water clusters, H3O(+)(H2O)(n) and NH4(+)(H2O)(n), and D2O.	Water	111-114	H3 clustered histone 15	Homo sapiens	104-107
18846302-1	2008	Hydrogen/deuterium exchange in reactions of H3O(+)(H2O)n and NH4(+)(H2O)n (1 &lt; or = n &lt; or = 30) with D2O has been studied experimentally at center-of-mass collisions energies of &lt; or = 0.2 eV.	Water	51-54	H3 clustered histone 15	Homo sapiens	44-47
18846302-2	2008	For a given cluster size, the cross-sections for H3O(+)(H2O)n and NH4(+)(H2O)n are similar, indicating a structural resemblance and energetics of binding.	Water	56-59	H3 clustered histone 15	Homo sapiens	49-52
18846302-3	2008	For protonated pure water clusters, H3O(+)(H2O)n, reacting with D2O the main H/D exchange mechanism is found to be proton catalyzed.	Water	20-25	H3 clustered histone 15	Homo sapiens	36-39
18846302-3	2008	For protonated pure water clusters, H3O(+)(H2O)n, reacting with D2O the main H/D exchange mechanism is found to be proton catalyzed.	Water	43-46	H3 clustered histone 15	Homo sapiens	36-39
17707551-5	2009	Moreover, ABAD suppressed the cytotoxic effects caused by cellular 4-HNE, which were produced through excess reactive oxygen species (ROS) by treatment with an inhibitor of mitochondrial respiration, antimycin A or by adding H(2)O(2).	Water	225-231	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	10-14
33736148-14	2021	However, this study strongly recommends future "plausible world" regional rivalry pathways (SSP3) scenario-combinations into consideration for policymaking in regard to water management as well as migration planning over South Asia.	Water	169-174	SUMO specific peptidase 3	Homo sapiens	92-96
18708067-1	2008	Aquaporin-4 (AQP4) water channels are expressed strongly in glial cells, where they play a role in brain water balance, neuroexcitation, and glial cell migration.	Water	19-24	aquaporin 4	Mus musculus	0-11
18708067-1	2008	Aquaporin-4 (AQP4) water channels are expressed strongly in glial cells, where they play a role in brain water balance, neuroexcitation, and glial cell migration.	Water	19-24	aquaporin 4	Mus musculus	13-17
33928984-0	2021	Synthesis, characterization and thermal behaviour of solid phases in the quasi-ternary system Mg(SCN)2-H2O-THF.	Water	103-106	growth factor independent 1 transcriptional repressor	Homo sapiens	94-102
18708067-1	2008	Aquaporin-4 (AQP4) water channels are expressed strongly in glial cells, where they play a role in brain water balance, neuroexcitation, and glial cell migration.	Water	105-110	aquaporin 4	Mus musculus	0-11
18708067-1	2008	Aquaporin-4 (AQP4) water channels are expressed strongly in glial cells, where they play a role in brain water balance, neuroexcitation, and glial cell migration.	Water	105-110	aquaporin 4	Mus musculus	13-17
18809413-8	2008	Remarkably, proliferating cell nuclear antigen (PCNA) and Ki-67 levels in the salivary glands of water-fed NOD mice were significantly elevated in comparison to BALB/c control mice; in contrast, PCNA and Ki-67 levels in EGCG-fed NOD animals were similar to BALB/c mice.	Water	97-102	proliferating cell nuclear antigen	Mus musculus	12-46
18809413-8	2008	Remarkably, proliferating cell nuclear antigen (PCNA) and Ki-67 levels in the salivary glands of water-fed NOD mice were significantly elevated in comparison to BALB/c control mice; in contrast, PCNA and Ki-67 levels in EGCG-fed NOD animals were similar to BALB/c mice.	Water	97-102	proliferating cell nuclear antigen	Mus musculus	48-52
18809413-8	2008	Remarkably, proliferating cell nuclear antigen (PCNA) and Ki-67 levels in the salivary glands of water-fed NOD mice were significantly elevated in comparison to BALB/c control mice; in contrast, PCNA and Ki-67 levels in EGCG-fed NOD animals were similar to BALB/c mice.	Water	97-102	antigen identified by monoclonal antibody Ki 67	Mus musculus	58-63
33928984-1	2021	Mg(SCN)2 4H2O can be converted into previously unknown compounds Mg(SCN)2 (4 - x) H2O xTHF with x = 0, 2 and 4 by multiple recrystallization in tetrahydrofuran (THF).	Water	10-13	growth factor independent 1 transcriptional repressor	Homo sapiens	0-8
18809413-8	2008	Remarkably, proliferating cell nuclear antigen (PCNA) and Ki-67 levels in the salivary glands of water-fed NOD mice were significantly elevated in comparison to BALB/c control mice; in contrast, PCNA and Ki-67 levels in EGCG-fed NOD animals were similar to BALB/c mice.	Water	97-102	proliferating cell nuclear antigen	Mus musculus	195-199
18809413-8	2008	Remarkably, proliferating cell nuclear antigen (PCNA) and Ki-67 levels in the salivary glands of water-fed NOD mice were significantly elevated in comparison to BALB/c control mice; in contrast, PCNA and Ki-67 levels in EGCG-fed NOD animals were similar to BALB/c mice.	Water	97-102	antigen identified by monoclonal antibody Ki 67	Mus musculus	204-209
33928984-8	2021	All investigated Mg(SCN)2 (4 - x) H2O xTHF phases exhibit a remarkable anisotropic thermal expansion, and Mg(SCN)2 4H2O and Mg(SCN)2 2THF were found to show both positive and negative thermal expansion coefficients.	Water	34-37	growth factor independent 1 transcriptional repressor	Homo sapiens	17-25
34036349-9	2021	In these compartments, the water content was significantly higher in patients with POMC and MC4R mutation than in control-groups.	Water	27-32	melanocortin 4 receptor	Homo sapiens	92-96
18721951-0	2008	Tap water irrigation and additives to optimize success with the Malone antegrade continence enema: the Indiana University algorithm.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
18721951-1	2008	PURPOSE: We report the long-term effectiveness of standard tap water for Malone antegrade continence enema irrigation as well as our algorithm for managing refractory constipation/fecal incontinence in a large single institution experience.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
34013923-1	2021	The accessible at-boron-BINOLated 3,5-bis(4-aminostyryl)ated BODIPY scaffold is highlighted as a workable platform for developing enantiopure small organic molecules exhibiting CPL in the NIR region, even in water solution, the latter being key for CPL-based bioapplications.	Water	208-213	hephaestin	Homo sapiens	177-180
18677274-10	2008	More than 99% of bactericidal or fungicidal activity was noted for all species, except for Candida albicans, in tap water at either pH 7.0 or 8.4.	Water	116-121	nuclear RNA export factor 1	Homo sapiens	112-115
34013923-1	2021	The accessible at-boron-BINOLated 3,5-bis(4-aminostyryl)ated BODIPY scaffold is highlighted as a workable platform for developing enantiopure small organic molecules exhibiting CPL in the NIR region, even in water solution, the latter being key for CPL-based bioapplications.	Water	208-213	hephaestin	Homo sapiens	249-252
34013923-2	2021	Synthetic simplicity, noticeable chiroptical efficiency in the NIR and the possibility to access water-soluble emitters pave the way for advancing CPL tools based on organic emitters and NIR radiation.	Water	97-102	hephaestin	Homo sapiens	147-150
25983985-0	2008	The relationship between effluent potassium due to cellular release, free water transport and CA125 in peritoneal dialysis patients.	Water	74-79	mucin 16, cell surface associated	Homo sapiens	94-99
33736356-7	2021	Tap water supply had the lowest global warming impact (0.17 kg CO2-eq.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
18555497-11	2008	Following the earthquake, drinking stream water or tap water without boiling or chlorination may have led to a common source water-borne outbreak of rotavirus gastroenteritis.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
33736356-9	2021	The most efficient strategy to reduce the environmental impact of household"s water use is to shift the water consumption from bottled to tap water consumption.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	138-141
33736356-9	2021	The most efficient strategy to reduce the environmental impact of household"s water use is to shift the water consumption from bottled to tap water consumption.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	138-141
33736356-9	2021	The most efficient strategy to reduce the environmental impact of household"s water use is to shift the water consumption from bottled to tap water consumption.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	138-141
33736356-11	2021	day-1 in case of groundwater-based tap water.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	35-38
33736356-12	2021	These results provide insights into sustainable water use for multiple consumption patterns and can be used to better frame the environmental benefits of tap water use.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	154-157
33736356-12	2021	These results provide insights into sustainable water use for multiple consumption patterns and can be used to better frame the environmental benefits of tap water use.	Water	158-163	nuclear RNA export factor 1	Homo sapiens	154-157
18716520-0	2008	F-18 fluorodeoxyglucose uptake in gastric adenoma after stomach distention by water.	Water	78-83	mastermind like domain containing 1	Homo sapiens	0-4
34040383-11	2021	The mean coliform bacteria of water and hand rinsate samples were 4.2 +- 0.8 and 4.1 +- 0.8 log CFU/mL, respectively.	Water	30-35	thrombopoietin	Mus musculus	100-102
18511552-0	2008	Impaired olfaction in mice lacking aquaporin-4 water channels.	Water	47-52	aquaporin 4	Mus musculus	35-46
18511552-1	2008	Aquaporin-4 (AQP4) is a water-selective transport protein expressed in glial cells throughout the central nervous system.	Water	24-29	aquaporin 4	Mus musculus	0-11
18511552-1	2008	Aquaporin-4 (AQP4) is a water-selective transport protein expressed in glial cells throughout the central nervous system.	Water	24-29	aquaporin 4	Mus musculus	13-17
34006980-1	2021	Aquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain.	Water	36-41	aquaporin 4	Homo sapiens	0-11
18511552-5	2008	The olfactory epithelium in AQP4-null mice had identical appearance, but did not express AQP4, and had approximately 12-fold reduced osmotic water permeability.	Water	141-146	aquaporin 4	Mus musculus	28-32
18558402-8	2008	The water-soluble secreted form of PPG at a concentration of 1 microg glycan/ml seems to be a potent inducer of ROS and IL-10 and to a lesser extent of IFN-gamma and IL-12.	Water	4-9	interleukin 10	Homo sapiens	120-125
34006980-1	2021	Aquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain.	Water	36-41	aquaporin 4	Homo sapiens	13-17
34006980-2	2021	AQP4 is crucial for the regulation of homeostatic water movement across the blood-brain barrier (BBB).	Water	50-55	aquaporin 4	Homo sapiens	0-4
32688810-1	2008	Alternative oxidase (AOX) is a terminal quinol oxidase located in the respiratory electron transport chain that catalyses the oxidation of quinol and the reduction of oxygen to water.	Water	177-182	acyl-CoA oxidase 1	Homo sapiens	0-19
33712161-5	2021	Furthermore, these DC TEMPO-CNF films revealed superior thermal stability and excellent water resistance compared to neat TEMPO-CNF films without crosslinked domains.	Water	88-93	NPHS1 adhesion molecule, nephrin	Homo sapiens	28-31
32688810-1	2008	Alternative oxidase (AOX) is a terminal quinol oxidase located in the respiratory electron transport chain that catalyses the oxidation of quinol and the reduction of oxygen to water.	Water	177-182	acyl-CoA oxidase 1	Homo sapiens	21-24
18812056-1	2008	The discovery of a specific autoantibody response in neuromyelitis optica (NMO) patients, which selectively targets astrocytic end feet at the glia limitans1 and which is directed against the water channel aquaporin-4 (AQP-4)2 was a milestone in defining this disease entity and profoundly changed our view regarding its pathogenesis.3 Indirect evidence, coming from clinical observations and pathology strongly suggest that these autoantibodies play a major role in driving the disease process.	Water	192-197	aquaporin 4	Homo sapiens	206-217
18812056-1	2008	The discovery of a specific autoantibody response in neuromyelitis optica (NMO) patients, which selectively targets astrocytic end feet at the glia limitans1 and which is directed against the water channel aquaporin-4 (AQP-4)2 was a milestone in defining this disease entity and profoundly changed our view regarding its pathogenesis.3 Indirect evidence, coming from clinical observations and pathology strongly suggest that these autoantibodies play a major role in driving the disease process.	Water	192-197	aquaporin 4	Homo sapiens	219-224
34025367-5	2021	Results found that administration of Anti-Acrp30, a neutralizing antibody of adiponectin, obviously reverses sodium hydrosulfide (NaHS, an exogenous H2S donor)-induced the inhibition on CRS-induced cognitive impairment according to Y-maze test, Novel object recognition (NOR) test, and Morris water maze (MWM) test.	Water	293-298	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	42-48
18695595-3	2008	Our aim was to establish the optimal duration of cooling using cold running tap water to treat the acute burn.	Water	80-85	putative ABC-transporter	Sus scrofa	76-79
34025367-5	2021	Results found that administration of Anti-Acrp30, a neutralizing antibody of adiponectin, obviously reverses sodium hydrosulfide (NaHS, an exogenous H2S donor)-induced the inhibition on CRS-induced cognitive impairment according to Y-maze test, Novel object recognition (NOR) test, and Morris water maze (MWM) test.	Water	293-298	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	77-88
33949543-0	2021	Water-assisted spin-flop antiferromagnetic behaviour of hydrophobic Cu-based metal-organic frameworks.	Water	0-5	spindlin 1	Homo sapiens	15-19
18765759-5	2008	Applications of CBNG water significantly increased soil EC, SAR, and ESP values (up to 21, 74, and 24 times, respectively) compared with nonirrigated soils.	Water	21-26	sarcosine dehydrogenase	Homo sapiens	60-63
33561476-4	2021	Water balance in the brain is tightly regulated, primarily by aquaporin 4 (AQP4) channels, which are mainly expressed in perivascular astrocytic end-feet.	Water	0-5	aquaporin 4	Mus musculus	62-73
18613258-1	2008	The assignment of singlet at 1.55 ppm and the 1:1:1 triplet at 1.519 ppm to H(2)O and HOD in the 400 MHz (1)H NMR spectrum of CDCl(3) solvent were supported by complete basis set (CBS) GIAO-B3LYP calculated chemical shift and the CBS B3LYP estimated (2)J(D,H) spin-spin coupling constant (SSCC).	Water	76-81	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	192-195
18758137-4	2008	The crystal structures of the VDR bound to these analogs provide a molecular explanation for the interaction between the 2alpha-substituents and water molecules exist in the VDR-ligand binding domain.	Water	145-150	vitamin D receptor	Homo sapiens	30-33
18758137-4	2008	The crystal structures of the VDR bound to these analogs provide a molecular explanation for the interaction between the 2alpha-substituents and water molecules exist in the VDR-ligand binding domain.	Water	145-150	vitamin D receptor	Homo sapiens	174-177
33561476-4	2021	Water balance in the brain is tightly regulated, primarily by aquaporin 4 (AQP4) channels, which are mainly expressed in perivascular astrocytic end-feet.	Water	0-5	aquaporin 4	Mus musculus	75-79
33610009-2	2021	It is made of astroglia cells, whose perikaryon extensions strongly express aquaporin-4 water channels (AQP4).	Water	88-93	aquaporin 4	Homo sapiens	76-87
18755978-5	2008	These movements expand the permeation pathway, leading to an increase in accessibility to water around TM3.	Water	90-95	tropomyosin 3	Homo sapiens	103-106
19142848-7	2009	In this report, we develop a relatively simple pumping system coupled to a dew point generator to calibrate an ICOS-based instrument (Los Gatos Research Water Vapor Isotope Analyzer (WVIA) DLT-100) under various pressures using liquid water with known isotopic signatures.	Water	153-158	inducible T cell costimulator	Homo sapiens	111-115
33610009-2	2021	It is made of astroglia cells, whose perikaryon extensions strongly express aquaporin-4 water channels (AQP4).	Water	88-93	aquaporin 4	Homo sapiens	104-108
18945445-1	2009	Aquaporin-4 (AQP4) is a water channel protein that plays an important role in water movement in the central nervous system (CNS).	Water	24-29	aquaporin 4	Homo sapiens	0-11
18945445-1	2009	Aquaporin-4 (AQP4) is a water channel protein that plays an important role in water movement in the central nervous system (CNS).	Water	24-29	aquaporin 4	Homo sapiens	13-17
18698031-8	2008	These clones were transplanted in nude mice and a clear Chk1 down-regulation was shown in tumor samples of mice given tetracycline in the drinking water by immunohistochemical detection of Chk1 protein.	Water	147-152	checkpoint kinase 1	Mus musculus	56-60
18698031-8	2008	These clones were transplanted in nude mice and a clear Chk1 down-regulation was shown in tumor samples of mice given tetracycline in the drinking water by immunohistochemical detection of Chk1 protein.	Water	147-152	checkpoint kinase 1	Mus musculus	189-193
18945445-1	2009	Aquaporin-4 (AQP4) is a water channel protein that plays an important role in water movement in the central nervous system (CNS).	Water	78-83	aquaporin 4	Homo sapiens	0-11
18945445-1	2009	Aquaporin-4 (AQP4) is a water channel protein that plays an important role in water movement in the central nervous system (CNS).	Water	78-83	aquaporin 4	Homo sapiens	13-17
33610009-4	2021	Within the glymphatic system, convective exchange of cerebrospinal fluid (CSF) and interstitial fluid (ISF) components takes place, through aquaporin-4 water channels that facilitate fluid exchange.	Water	152-157	aquaporin 4	Homo sapiens	140-151
18578544-7	2008	The method was successfully used to determine total adsorbable organic halogens (AOX) in well water and leachates, and the results validated against an AOX reference method.	Water	94-99	acyl-CoA oxidase 1	Homo sapiens	81-84
33932069-9	2021	What"s more, tumor promoting effect of NAXE knockdown in HCC xenograft can be abolished by giving mice NAC in drinking water.	Water	119-124	NLR family, pyrin domain containing 1A	Mus musculus	103-106
18511455-0	2008	Novel variants in human Aquaporin-4 reduce cellular water permeability.	Water	52-57	aquaporin 4	Homo sapiens	24-35
18511455-13	2008	Cellular assays confirmed that four variant AQP4 channels reduced normalized water permeability to between 26 and 48% of the reference (P &lt; 0.001), while the M278T mutation increased normalized water permeability (P &lt; 0.001).	Water	77-82	aquaporin 4	Homo sapiens	44-48
33949893-8	2021	RESULTS: Spontaneous preterm birth at 20-31 wk was increased in association with tap water nitrate concentrations during pregnancy of 5 to <10mg/L [odds ratio (OR)=1.47; 95% confidence interval (CI): 1.29, 1.67] and >=10mg/L (OR=2.52; 95% CI: 1.49, 4.26) compared with <5mg/L (as nitrogen).	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
18511455-14	2008	We identified multiple novel AQP4 SNPs and showed that four nsSNPs reduced water permeability.	Water	75-80	aquaporin 4	Homo sapiens	29-33
19041202-7	2009	The results have revealed that Fry"s reagent comprising cupric chloride 90 g, hydrochloric acid 120 mL and water 100mL provided the necessary contrast and was concluded to be the most sensitive.	Water	107-112	FRY microtubule binding protein	Homo sapiens	31-34
33949893-12	2021	Notably, we estimated modestly increased odds associated with tap water nitrate concentrations of 5 to <10mg/L (below the federal drinking water standard of 10mg/L) relative to <5mg/L.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
19081100-10	2009	The method detection limit (MDL) for TRA in ethanol:water (12.5:87.5, v/v) solution in this study was 7.08 ng L(-1) whereas the MDL for TRA in pure water was 2.85 ng L(-1).	Water	148-153	T cell receptor alpha locus	Homo sapiens	136-139
33949893-12	2021	Notably, we estimated modestly increased odds associated with tap water nitrate concentrations of 5 to <10mg/L (below the federal drinking water standard of 10mg/L) relative to <5mg/L.	Water	139-144	nuclear RNA export factor 1	Homo sapiens	62-65
18481120-7	2008	Since each non-terminal ANK repeat has two hydrophobic sides, we may hypothesize that at least one hydrophobic side must be fully covered and shielded from the water as a necessary, but not sufficient, condition to maintain ANK repeat stability.	Water	160-165	ankyrin 1	Homo sapiens	24-27
33989179-0	2021	Spatial and seasonal variability in the water chemistry of Kabar Tal wetland (Ramsar site), Bihar, India: multivariate statistical techniques and GIS approach.	Water	40-45	transaldolase 1	Homo sapiens	65-68
18481120-7	2008	Since each non-terminal ANK repeat has two hydrophobic sides, we may hypothesize that at least one hydrophobic side must be fully covered and shielded from the water as a necessary, but not sufficient, condition to maintain ANK repeat stability.	Water	160-165	ankyrin 1	Homo sapiens	224-227
18700282-4	2008	Our results show that water maze training induces a rapid recruitment of NMDAR subunits (NR1, NR2A, NR2B) and PSD-95 to synaptic lipid rafts and decrease in the post-synaptic density plus an increase of NR2B phosphorylation at tyrosine 1472 in the rat insular cortex.	Water	22-27	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	100-104
18700282-4	2008	Our results show that water maze training induces a rapid recruitment of NMDAR subunits (NR1, NR2A, NR2B) and PSD-95 to synaptic lipid rafts and decrease in the post-synaptic density plus an increase of NR2B phosphorylation at tyrosine 1472 in the rat insular cortex.	Water	22-27	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	203-207
19001510-7	2009	Here we report for the first time that aquaporin5 (AQP5), a member of the aquaporin water channel family, was dramatically downregulated during parturition (approximately 100-fold by microarray and approximately 50-fold by real-time PCR).	Water	84-89	aquaporin 5	Rattus norvegicus	39-49
19001510-7	2009	Here we report for the first time that aquaporin5 (AQP5), a member of the aquaporin water channel family, was dramatically downregulated during parturition (approximately 100-fold by microarray and approximately 50-fold by real-time PCR).	Water	84-89	aquaporin 5	Rattus norvegicus	51-55
33929043-6	2021	Moreover, the oil-water interfacial tension with WPI decreased from 9.20 mN/m to 3.29 mN/m upon increasing the Lip-to-WPI ratio.	Water	18-23	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	111-114
19222249-3	2009	Current therapeutic strategies include topical aluminum salts, tap-water iontophoresis, oral anticholinergic agents, local surgical approaches, and sympathectomies.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
18723490-0	2008	Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.	Water	44-49	MDM2 proto-oncogene	Homo sapiens	71-75
33986750-1	2021	Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system (CNS), characterized by pathogenic, complement-activating autoantibodies against the main water channel in the CNS, aquaporin 4 (AQP4).	Water	205-210	aquaporin 4	Homo sapiens	231-242
18502432-10	2008	Finally, the study was applied to determine the vitamins in several real aqueous samples including mixed juice fruit, urine and tap water samples and relatively good results were obtained.	Water	132-137	nuclear RNA export factor 1	Homo sapiens	128-131
18789711-1	2009	Radon concentrations are measured in the tap water collected in different areas in Marrakech (Morocco) by using liquid scintillation techniques.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
33986750-1	2021	Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system (CNS), characterized by pathogenic, complement-activating autoantibodies against the main water channel in the CNS, aquaporin 4 (AQP4).	Water	205-210	aquaporin 4	Homo sapiens	244-248
18777014-4	2009	Wheat germ lipase had a high activity and enantioselectivity only in n-hexane with a high initial water activity (alpha(w) = 0.97), especially with 1-phenylethanol (C 32%, E &gt; 200).	Water	98-103	probable feruloyl esterase A	Triticum aestivum	11-17
33925363-1	2021	Inquiries into the participation of short hydrogen bonds in stabilizing transition states and intermediate states in the thrombin, factor Xa, plasmin and activated protein C-catalyzed reactions revealed that specific binding of effectors at Sn, n = 1-4 and S"n, n = 1-3 and at remote exosites elicit complex patterns of hydrogen bonding and involve water networks.	Water	349-354	coagulation factor X	Homo sapiens	131-140
19471093-3	2009	Islet cells express aquaporin 7 (AQP7), which is permeable to urea and glycerol in addition to water.	Water	95-100	aquaporin 7	Rattus norvegicus	20-31
19471093-3	2009	Islet cells express aquaporin 7 (AQP7), which is permeable to urea and glycerol in addition to water.	Water	95-100	aquaporin 7	Rattus norvegicus	33-37
18540662-13	2008	Some of the conclusions about the reactions of halogenated alkoxyl radicals are supported by quantum chemical calculations [B3LYP/6-31G(d,p)] taking into account the influence of water as a dielectric continuum [by the self-consistent reaction field polarized continuum model (SCRF=PCM) technique].	Water	179-184	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	126-129
18543983-1	2008	Effects of urea on protein stability have been studied from all-atom molecular dynamics simulations of ubiquitin, G311 protein, and immunoglobulin binding domain (B1) of streptococcal protein G (GB1) in water and 8 M aqueous urea solution.	Water	203-208	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	195-198
18495203-3	2008	Dosing of orthophosphate against corrosion did not increase microbial growth potential in the water and in the biofilm in both corroded and uncorroded systems receiving tap water with a low content of organic carbon and of biodegradable organic fraction.	Water	173-178	nuclear RNA export factor 1	Homo sapiens	169-172
33485974-4	2021	METHODS: RT-qPCR was used to detect the effects of water extract of Polygoni Multiflori Radix (PMR) and its main components on the mRNA expression of CYP3A4 and UGT1A1 in human hepatic parenchyma cell line L02.	Water	51-56	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	161-167
18495203-4	2008	However, in tap water having a high concentration of organic carbon from acetate addition, orthophosphate addition promoted the growth of bacteria, allowed more bacteria to assemble on corroded and uncorroded surfaces, and increased the consumption of organic carbon.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
18594344-2	2008	METHODS: Tap water was collected from the bathroom sink of 100 households in Hong Kong and tested for the presence of Acanthamoeba by means of PCR amplification.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
19089325-6	2009	GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation.	Water	84-89	guanylate cyclase activator 2B	Homo sapiens	42-53
33928264-5	2021	We demonstrate an unexpectedly high water solubility of AFA reaching 672 mM, two orders of magnitude higher than reported previously.	Water	36-41	AFA	Homo sapiens	56-59
17957381-7	2008	These observations suggest that activation of Epac by cAMP may also contribute to the action of vasopressin in regulating osmotic water permeability.	Water	130-135	Rap guanine nucleotide exchange factor 3	Homo sapiens	46-50
33912141-0	2021	Clonal CTX-M-15-Producing Escherichia coli ST-949 Are Present in German Surface Water.	Water	80-85	hypothetical protein	Escherichia coli	7-15
18585247-12	2008	Fe(III) and Mn(II) ions, present in treated tap water in relatively high concentrations, did not interfere.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
18585247-13	2008	Effective pH adjusting of the loaded solution in on-line mode, when applying diluted Clark-Lubs buffering solution, allowed accurate copper determination in tap water (compared to graphite furnace atomic absorption spectrometry, GFAAS) using standard addition or combination calibration method.	Water	161-166	nuclear RNA export factor 1	Homo sapiens	157-160
33954047-7	2021	(2) The ARC and SHC type were most beneficial for soil and water conservation in the ECLP; The APC and ABC are not conductive to the prevention of regional soil erosion.	Water	59-64	SHC adaptor protein 1	Homo sapiens	16-19
18575574-9	2008	Finally, treatment of mice with 5 mM butyrate added to drinking water for 24 h increased colonic PepT1 mRNA and protein expression levels, as well as enhanced PepT1 transport activity in colonic apical membranes vesicles.	Water	64-69	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	97-102
33873066-0	2021	RP-18 TLC retention data and calculated physico-chemical parameters as predictors of soil-water partition and bioconcentration of organic sunscreens.	Water	90-95	pre-mRNA processing factor 3	Homo sapiens	0-5
18395010-2	2008	Our previous studies showed that TTF-1 plays an important role in water homeostasis in the subfornical organ of rats and is involved in cerebrospinal fluid formation by regulation of aquaporin-1 transcription in the choroid plexus.	Water	66-71	transcription termination factor 1	Rattus norvegicus	33-38
33873066-1	2021	RP-18 TLC chromatography was used to evaluate the impact on the environment (mobility in soil expressed as soil-water partition coefficient, log Koc; bioconcentration factor in aquatic organisms, log BCF) of several cosmetic raw materials - sunscreens, preservatives and vitamins.	Water	112-117	pre-mRNA processing factor 3	Homo sapiens	0-5
33742797-7	2021	Water-soluble ions, OC, EC and metal elements account for 40%, 19%, 5%, and 7% on clean days, 46%, 18%, 4%, and 5% on days with light-moderate pollution, and 46%, 21%, 4%, and 4% on days with heavy-severe pollution, respectively.	Water	0-5	small proline rich protein 2A	Homo sapiens	163-166
18459808-1	2008	Treatment of alkenes with NBS, a nitrile, NaHCO3 and water in the presence of Cu(OTf)2 or Zn(OTf)2 is reported to furnish oxazolines in one pot and good yields.	Water	53-58	POU class 2 homeobox 2	Homo sapiens	78-86
18423519-10	2008	The environmental load was evaluated by carbon dioxide generation as an index and it was found that the carbon dioxide generated by the electrolysis method was 1/70 lower than that by the dilution method with tap water.	Water	213-218	nuclear RNA export factor 1	Homo sapiens	209-212
33927974-0	2021	Development of glucose oxidase-chitosan immobilized paper biosensor using screen-printed electrode for amperometric detection of Cr(VI) in water.	Water	139-144	hydroxyacid oxidase 1	Homo sapiens	15-30
18540354-3	2008	Long spinal cord lesion on spinal MRI is a diagnostic finding of opticospinal MS with autoantibodies to the aquaporin-4 water channel.	Water	120-125	aquaporin 4	Homo sapiens	108-119
33508402-7	2021	The data obtained from this study showed that the use of miR mimic and Q10 increased the level of miR-149, decreased the extent of neurological defects and tissue damage, increased BBB integrity, decreased brain water percentage and also decreased the level of inflammatory cytokines and MMPs.	Water	212-217	myosin regulatory light chain interacting protein	Rattus norvegicus	57-60
18405950-7	2008	Several genes were in common between the EtOH and both the SAC and water groups in the synaptic transmission (e.g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories.	Water	67-72	S100 calcium binding protein B	Rattus norvegicus	168-173
18405950-7	2008	Several genes were in common between the EtOH and both the SAC and water groups in the synaptic transmission (e.g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories.	Water	67-72	protein kinase C, alpha	Rattus norvegicus	175-180
33549622-9	2021	This work showed that Mg-rich C3A is a promising candidate for simultaneous removal of NH4+ and PO43-, shedding light on practical water remediation.	Water	131-136	complement C3	Homo sapiens	30-33
18470871-2	2008	The method was applied to model reaction mixtures in the study of the formation of iodoacetic acid after chlorinated tap water was boiled in the presence of potassium iodide or iodized table salt.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
19035047-6	2008	Expression of NR1, NR2A and NR2B in hippocampus of the rats drinking purified water was lower than those drinking tap water, especially at low lead exposure (50 mg/L) (P &lt; 0.05).	Water	78-83	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	28-32
19035047-8	2008	CONCLUSION: Compared with drinking tap water, drinking purified water might increase the accumulation of brain lead, lower NR1, NR2A, NR2B expression and delay the spatial learning and memory ability under chronic lead exposure in water.	Water	64-69	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	134-138
19035047-8	2008	CONCLUSION: Compared with drinking tap water, drinking purified water might increase the accumulation of brain lead, lower NR1, NR2A, NR2B expression and delay the spatial learning and memory ability under chronic lead exposure in water.	Water	64-69	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	134-138
33244694-1	2021	The Walawe river basin is one of the important watersheds in Sri Lanka subjected to water scarcity due to intensive exploitation for irrigation and domestic purposes.	Water	47-52	sorcin	Homo sapiens	61-64
18453407-5	2008	Kinetic parameters (E(a), ln A, k(2)) quantified for the alkaline hydrolysis of RDX and HMX in deionized water (30-50 degrees C, pH 10-12) agreed relatively well with abiotic degradation rates determined in sterilized natural coastal waters (50 and 60 degrees C, variable salinity) even if the latter were generally slightly faster than the former.	Water	105-110	radixin	Homo sapiens	80-83
33582182-2	2021	Aquaporin 5 (AQP5) represents an essential membrane water channel.	Water	52-57	aquaporin 5	Mus musculus	0-11
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Water	284-289	solute carrier family 12 member 1	Rattus norvegicus	84-89
33360887-5	2021	Furthermore, the FeCoNiSx/NF acted as the anode towards overall water electrolysis with acceptable results, where commercial Pt/C dropped on the NF worked as the cathode.	Water	64-69	neurofascin	Homo sapiens	26-28
33837053-15	2021	Single agent OH2 induced alterations in the tumor microenvironment, with clear increases in CD3+ and CD8+ cell density and programmed death-ligand 1 expression in the patients" post-treatment biopsies relative to baseline.	Water	13-16	CD8a molecule	Homo sapiens	101-104
18379423-1	2008	BACKGROUND: Laboratory evidence suggests tap water disinfection by-products (DBPs) could have an effect very early in pregnancy, typically before clinical detectability.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
33580550-9	2021	The EDR2 film measurements in solid water presented the maximum penumbra reduction of 10 to 14 mm depending on the target size.	Water	36-41	polyhomeotic homolog 2	Homo sapiens	4-8
18624196-8	2008	The NAP has positive correlation with c(EPC) and the trend is that the sediment with higher NAP easily desorbs phosphorus to the water, contrarily the sediment with lower NAP easily adsorbs phosphorus.	Water	129-134	catenin beta like 1	Homo sapiens	4-7
18624196-8	2008	The NAP has positive correlation with c(EPC) and the trend is that the sediment with higher NAP easily desorbs phosphorus to the water, contrarily the sediment with lower NAP easily adsorbs phosphorus.	Water	129-134	catenin beta like 1	Homo sapiens	92-95
18624196-8	2008	The NAP has positive correlation with c(EPC) and the trend is that the sediment with higher NAP easily desorbs phosphorus to the water, contrarily the sediment with lower NAP easily adsorbs phosphorus.	Water	129-134	catenin beta like 1	Homo sapiens	92-95
33601190-1	2021	INTRODUCTION: Pegloticase is a recombinant PEGylated uricase that converts relatively insoluble urate to highly water-soluble allantoin, which is readily excreted by the kidneys.	Water	112-117	urate oxidase (pseudogene)	Homo sapiens	53-60
18492345-0	2008	Measurement of fuel oxygenates in tap water using solid-phase microextraction gas chromatography-mass spectrometry.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
33751889-4	2021	Herein, we report the successful immobilization of underivatized Ru(II)-based WOCs (Ru-Cat1 = [Ru(tpy) (bpy) (H2O)]2+ (tpy = 2,2":6"2""-terpyridine and bpy = 2,2"-bipyridine) and Ru-Cat2 = [Ru(Mebimpy) (bpy) (H2O)]2+ (Mebimpy = 2,6-bis(1-methylbenzimidazol-2-yl) pyridine)) and the Ru(II) polypyridyl chromophore Ru-C3 = [Ru(bpy)3]2+ onto a FTO plasma-grafted poly(acrylic acid) surface (PAA FTO).	Water	110-113	transient receptor potential cation channel subfamily V member 6	Homo sapiens	87-91
18404226-6	2008	The direct DFT-MD calculations showed that the spin density distribution of excess electron is gradually changed from the water cluster (trapped electron state) to CF(2)Cl(2) as a function of time.	Water	122-127	spindlin 1	Homo sapiens	47-51
33751889-9	2021	We attribute the surface PCET and stability to the presence of a water ligand in the coordination sphere of immobilized Ru-Cat1 and Ru-Cat2 which can H-bond with negatively charged carboxylate groups of the cross-linked PAA brushes.	Water	65-70	transient receptor potential cation channel subfamily V member 6	Homo sapiens	123-127
18351769-0	2008	Water-compatible organocatalysts for direct asymmetric syn-aldol reactions of dihydroxyacetone and aldehydes.	Water	0-5	synemin	Homo sapiens	55-58
33967604-0	2021	Anti-inflammatory effects of Flos Lonicerae Japonicae Water Extract are regulated by the STAT/NF-kappaB pathway and HO-1 expression in Virus-infected RAW264.7 cells.	Water	54-59	signal transducer and activator of transcription 1	Homo sapiens	89-93
18468315-9	2008	(4) The recommended maximum CPAP should be 15 cm H2O (or recommended maximum IPAP of 20 cm H2O if on BPAP) for patients &lt; 12 years, and 20 cm H2O (or recommended maximum IPAP of 30 cm H2O if on BPAP) for patients &gt; or = 12 years.	Water	49-52	centromere protein J	Homo sapiens	28-32
18468315-9	2008	(4) The recommended maximum CPAP should be 15 cm H2O (or recommended maximum IPAP of 20 cm H2O if on BPAP) for patients &lt; 12 years, and 20 cm H2O (or recommended maximum IPAP of 30 cm H2O if on BPAP) for patients &gt; or = 12 years.	Water	91-94	centromere protein J	Homo sapiens	28-32
33994109-7	2021	In the water jet cell preparations, there were higher numbers of cells expressing CD146.	Water	7-12	melanoma cell adhesion molecule	Homo sapiens	82-87
18468315-9	2008	(4) The recommended maximum CPAP should be 15 cm H2O (or recommended maximum IPAP of 20 cm H2O if on BPAP) for patients &lt; 12 years, and 20 cm H2O (or recommended maximum IPAP of 30 cm H2O if on BPAP) for patients &gt; or = 12 years.	Water	91-94	centromere protein J	Homo sapiens	28-32
18468315-9	2008	(4) The recommended maximum CPAP should be 15 cm H2O (or recommended maximum IPAP of 20 cm H2O if on BPAP) for patients &lt; 12 years, and 20 cm H2O (or recommended maximum IPAP of 30 cm H2O if on BPAP) for patients &gt; or = 12 years.	Water	91-94	centromere protein J	Homo sapiens	28-32
18468315-17	2008	If there are continued obstructive respiratory events at 15 cm H2O of CPAP during the titration study, the patient may be switched to BPAP.	Water	63-66	centromere protein J	Homo sapiens	70-74
33994109-9	2021	Gene analysis showed higher expression of the adipocyte markers aP2 and GLUT4 in the adipocyte-differentiated water jet cell preparations, and ELISA indicated increased secretion of adiponectin from these cells.	Water	110-115	transcription factor AP-2 alpha	Homo sapiens	64-67
18275142-8	2008	Compound a-2/ b-2 contains dimers of [{Ni(f-RR-L)}2(l-Phe)(H2O)](3+)/[{Ni( f- SS-L)}2(d-Phe)(H2O)](3+) and 1D zigzag chains of {[Ni(f-RR-L)(l-Phe)](+)}n /{[Ni(f-SS-L)(d-Phe)](+) n .	Water	59-62	immunoglobulin kappa variable 5-2	Homo sapiens	14-17
18275142-8	2008	Compound a-2/ b-2 contains dimers of [{Ni(f-RR-L)}2(l-Phe)(H2O)](3+)/[{Ni( f- SS-L)}2(d-Phe)(H2O)](3+) and 1D zigzag chains of {[Ni(f-RR-L)(l-Phe)](+)}n /{[Ni(f-SS-L)(d-Phe)](+) n .	Water	93-96	immunoglobulin kappa variable 5-2	Homo sapiens	14-17
33849832-3	2021	Heat exposure of HL1 atrial myocytes was conducted using a water bath, and the effect of amiodarone on cell viability was assessed with MTS method; cell apoptosis was detected using flow cytometry, and the levels of IL-1beta, IL-6, TNF-alpha, SOD and MDA were detected with enzyme-linked immunosorbent assay (ELISA).	Water	59-64	asialoglycoprotein receptor 1	Mus musculus	17-20
18335212-9	2008	It was successfully used as an indicator electrode in potentiometric determination of terbium(III) ions with EDTA and in direct determination in tap water and binary mixtures with quantitative results.	Water	149-154	nuclear RNA export factor 1	Homo sapiens	145-148
18179769-1	2008	Tetramers of the mammalian water channel aquaporin-4 (AQP4) assemble into square arrays and mediate bidirectional water transport across the blood-brain interface.	Water	27-32	LOW QUALITY PROTEIN: aquaporin-4	Cricetulus griseus	41-52
18179769-1	2008	Tetramers of the mammalian water channel aquaporin-4 (AQP4) assemble into square arrays and mediate bidirectional water transport across the blood-brain interface.	Water	27-32	aquaporin 4	Homo sapiens	54-58
33759061-1	2021	A flexible nano-engineered natural mineral (carbon dot doped natural microcline) based membrane (MCPV) has been developed, which can efficiently detect the presence of hexavalent chromium (Cr6+) and trivalent iron (Fe3+) ions in water by altering its fluorescence emission.	Water	229-234	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	189-192
18179769-1	2008	Tetramers of the mammalian water channel aquaporin-4 (AQP4) assemble into square arrays and mediate bidirectional water transport across the blood-brain interface.	Water	114-119	LOW QUALITY PROTEIN: aquaporin-4	Cricetulus griseus	41-52
18179769-1	2008	Tetramers of the mammalian water channel aquaporin-4 (AQP4) assemble into square arrays and mediate bidirectional water transport across the blood-brain interface.	Water	114-119	aquaporin 4	Homo sapiens	54-58
33570938-5	2021	In this work, we use atom-detailed molecular dynamics simulations and a refined model structure of the Kv7.2 VSD in the active conformation in a membrane/water environment to study the effect of R207Q and four additional mutations of proven clinical importance.	Water	154-159	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	103-108
18324775-4	2008	Water content was 32-80% without collagen and increased to 230% with collagen at 37 degrees C. Hydrogels were highly flexible and relatively strong at 37 degrees C, with tensile strengths from 0.3 to 1.1 MPa and elongations at break from 344 to 1841% depending on NIPAAm/HEMAPLA ratio, AAc content, and polylactide length.	Water	0-5	glycine-N-acyltransferase	Homo sapiens	286-289
33289262-3	2021	The chirality induction in CD (g abs   -10 -4 ) and CPL (g lum   -10 -4 ) of P - SOF-1 from achiral SOF-1 can be presented using a small amount of adenosine-5"-triphosphate disodium (ATP) or adenosine-5"-diphosphate disodium (ADP) (only 0.4 equiv) in water.	Water	251-256	hephaestin	Homo sapiens	52-105
18267965-9	2008	AQP4 immunoreactivity at the injury site was increased in grey and white matter at 48 h. Taken together, our findings indicate that AQP4 provides a major route for excess water entry into the injured spinal cord, which in turn causes spinal cord swelling and elevated spinal cord pressure.	Water	171-176	aquaporin 4	Mus musculus	0-4
18267965-9	2008	AQP4 immunoreactivity at the injury site was increased in grey and white matter at 48 h. Taken together, our findings indicate that AQP4 provides a major route for excess water entry into the injured spinal cord, which in turn causes spinal cord swelling and elevated spinal cord pressure.	Water	171-176	aquaporin 4	Mus musculus	132-136
19013174-4	2009	Using male zebra finches, a highly gregarious estrildid, we now extend those findings to show that VT-Fos coexpression is induced by a positive social stimulus (a female), but not by a positive non-social stimulus (a water bath in bath-deprived birds), although the female and bath stimuli induced Fos equally within a nearby control region, the medial preoptic nucleus.	Water	217-222	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	102-105
33338936-8	2021	The proposed methods have an admissible precision and accuracy for determination of the two isomers in their binary mixtures in tap water as a real sample.	Water	132-137	nuclear RNA export factor 1	Homo sapiens	128-131
19204863-5	2009	Concentration of microcystin-LR was 650 microg L(-1) in the reservoir, while the tap water contained 2.5 microg L(-1).	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
18411377-1	2008	QUESTION: Owing to the recent concerns of lead (Pb) leaking into tap water, one of our female patients is concerned about the effects of Pb exposure to newborns while breastfeeding.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
33661638-0	2021	Anisotropic Janus SiP2 Monolayer as a Photocatalyst for Water Splitting.	Water	56-61	gem nuclear organelle associated protein 6	Homo sapiens	18-22
18309154-2	2008	Aquaporin-4 (AQP4) is the main water channel in the brain and has been shown to be critical for the development of brain edema after ischemia.	Water	31-36	aquaporin 4	Homo sapiens	0-11
18309154-2	2008	Aquaporin-4 (AQP4) is the main water channel in the brain and has been shown to be critical for the development of brain edema after ischemia.	Water	31-36	aquaporin 4	Homo sapiens	13-17
19012750-4	2009	Importantly, escape latency in the water maze in EP2 KO was longer than that in age-matched EP2 wild-type littermates (WT).	Water	35-40	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	49-52
19161405-1	2009	The Girard"s reagent P derivative of canthaxanthin ((GRP)(2)-canthaxanthin), a dicationic carotenoid, forms a highly water-dispersible complex with (2-hydroxypropyl)-gamma-cyclodextrin.	Water	117-122	gastrin releasing peptide	Homo sapiens	53-56
33551058-10	2021	In addition, successful detection of Cr6+ in tap water and Yangtze River water, indicating the real applications of Au NDC@Ag NRs probe in monitoring Cr6+ in environment.	Water	49-54	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	37-40
20099737-4	2009	In this study, water-soluble sodium alginates contained in active dressings Medisorb A were identified using electrophoresis on cellulose acetate CAE.	Water	15-20	gap junction protein alpha 8	Homo sapiens	146-149
18164742-6	2008	Except for silica, other nanoparticles rapidly aggregated in tap water due to electric double layer (EDL) compression.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
18164742-7	2008	The stability of silica in tap water is related to its low Hamaker constant.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
18199469-1	2008	The Sava River, the largest and most commercially valuable water body in the riparian countries, receives inputs of organic and inorganic compounds from a variety of domestic and industrial activities that may affect the health of human beings and wildlife.	Water	59-64	T-box transcription factor T	Homo sapiens	4-8
33742937-10	2021	In the water samples, the average concentrations of TOC, BOD5, COD, TN, NH4+-N, Kjeldahl nitrogen, TP, and PO43--P were 7.8, 0.6, 13.1, 2.5, 0.643, 1.3, 0.18, and 0.09 mg L-1, respectively, indicating a severe level of pollution.	Water	7-12	rhomboid 5 homolog 2	Homo sapiens	52-55
18423149-5	2008	RESULTS: The positive rate of proliferating cell nuclear antigen (PCNA) and the mean peak choline/water ratio in the experimental group were significantly higher than those in the control group and the peak choline /water ratio had a positive correlation with the positive rate of PCNA.	Water	216-221	proliferating cell nuclear antigen	Rattus norvegicus	30-64
18423149-5	2008	RESULTS: The positive rate of proliferating cell nuclear antigen (PCNA) and the mean peak choline/water ratio in the experimental group were significantly higher than those in the control group and the peak choline /water ratio had a positive correlation with the positive rate of PCNA.	Water	216-221	proliferating cell nuclear antigen	Rattus norvegicus	281-285
18785066-1	2009	OBJECTIVE: Na+/H+ exchanger isoform 3 (NHE-3) is responsible for net uptake of NaCl and water from the gastrointestinal (GI) tract.	Water	88-93	solute carrier family 9 member A3	Homo sapiens	11-37
33751067-2	2021	OBJECTIVE: Two eco-friendly spectrofluorimetric methods were proposed for the determination of three unexpected contaminants in drinking tap water.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	137-140
33751067-14	2021	HIGHLIGHTS: Both methods were found to be eco-friendly and were successfully applied for the determination of the emerging contaminants in drinking tap water.	Water	152-157	nuclear RNA export factor 1	Homo sapiens	148-151
18785066-1	2009	OBJECTIVE: Na+/H+ exchanger isoform 3 (NHE-3) is responsible for net uptake of NaCl and water from the gastrointestinal (GI) tract.	Water	88-93	solute carrier family 9 member A3	Homo sapiens	39-44
33600773-3	2021	Here, we show that humans lacking alpha-actinin-3 (XX) are superior in maintaining core body temperature during cold-water immersion due to changes in skeletal muscle thermogenesis.	Water	117-122	actinin alpha 3	Homo sapiens	34-49
18785066-11	2009	CONCLUSIONS: NHE-3 suppression is regulated differentially in CD and UC, which together with suppression of sodium pump activity will reduce NaCl and water uptake from the colonic lumen.	Water	150-155	solute carrier family 9 member A3	Homo sapiens	13-18
18322093-7	2008	The abilities of H(2)O(2), alkenyl aldehydes and 15d-PGJ(2) to raise [Ca(2+)](i) in mouse DRG neurons were greatly reduced in neurons from trpa1(-/-) mice.	Water	17-22	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	139-144
33303991-3	2021	Our previous study has shown that salvianolic acid A (SAA), which is a water-soluble component from the root of Salvia Miltiorrhiza Bge, prevents thrombosis with a mild inhibitory effect on platelet aggregation.	Water	71-76	serum amyloid A1 cluster	Homo sapiens	54-57
18274911-3	2008	OBJECTIVE: The ENaC found in many transporting epithelia play a key role in the regulation of salts and water homeostasis, cellular pH, cell volume, and cell function.	Water	104-109	amiloride-sensitive sodium channel subunit alpha	Cavia porcellus	15-19
19759456-8	2009	The presence of these compounds in the tap water, surface water and animal and human tissues indicates their global contamination and bioaccumulative phenomena in the ecosystems.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
19934515-6	2009	When pure urine was diluted with tap water, use of a higher tap water proportion for dilution expedited the electrolysis to achieve a nearly complete removal of phosphate in solution, but dilution caused the increase in energy consumption.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
19934515-6	2009	When pure urine was diluted with tap water, use of a higher tap water proportion for dilution expedited the electrolysis to achieve a nearly complete removal of phosphate in solution, but dilution caused the increase in energy consumption.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	60-63
19934515-6	2009	When pure urine was diluted with tap water, use of a higher tap water proportion for dilution expedited the electrolysis to achieve a nearly complete removal of phosphate in solution, but dilution caused the increase in energy consumption.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	33-36
18186079-8	2008	Aqp4, Cx43, and Kir4.1/Kir5.1 are co-localized to astrocytic end-feet at the brain vasculature, where they regulate potassium and water transport.	Water	130-135	aquaporin 4	Mus musculus	0-4
19934515-6	2009	When pure urine was diluted with tap water, use of a higher tap water proportion for dilution expedited the electrolysis to achieve a nearly complete removal of phosphate in solution, but dilution caused the increase in energy consumption.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
18186079-8	2008	Aqp4, Cx43, and Kir4.1/Kir5.1 are co-localized to astrocytic end-feet at the brain vasculature, where they regulate potassium and water transport.	Water	130-135	potassium inwardly-rectifying channel, subfamily J, member 16	Mus musculus	23-29
33569838-5	2021	Density functional theory calculations suggest that gamma-NiOOH in situ generated from the electrooxidation of NF would induce charge accumulation on the Fe sites of gamma-FeOOH NAs, leading to enhanced OER intermediates adsorption for water splitting.	Water	236-241	neurofascin	Homo sapiens	111-113
19033383-1	2008	Aquaporin-4 (AQP4), a key molecule for maintaining water and ion homeostasis in the central nervous system, is expressed in adult neural stem cells (ANSCs) as well as astrocytes.	Water	51-56	aquaporin 4	Mus musculus	0-11
33128181-10	2021	Future mechanical testing should consider using SPEG as a bath solution with an osmotic pressure which preserves fresh tissue water content.	Water	126-131	striated muscle enriched protein kinase	Homo sapiens	48-52
19033383-1	2008	Aquaporin-4 (AQP4), a key molecule for maintaining water and ion homeostasis in the central nervous system, is expressed in adult neural stem cells (ANSCs) as well as astrocytes.	Water	51-56	aquaporin 4	Mus musculus	13-17
18854171-1	2008	Aquaporin-4 (AQP4) is expressed in the perivascular and subpial astrocytes end-feet in mammalian brain, and plays a critical component of an integrated water and potassium homeostasis.	Water	152-157	aquaporin 4	Homo sapiens	0-11
18854171-1	2008	Aquaporin-4 (AQP4) is expressed in the perivascular and subpial astrocytes end-feet in mammalian brain, and plays a critical component of an integrated water and potassium homeostasis.	Water	152-157	aquaporin 4	Homo sapiens	13-17
18368618-5	2008	Zn and Cu were detected at high levels in water-soluble fractions (TP2 &gt; TP1).	Water	42-47	transition protein 2	Rattus norvegicus	67-70
18368618-5	2008	Zn and Cu were detected at high levels in water-soluble fractions (TP2 &gt; TP1).	Water	42-47	transition protein 1	Rattus norvegicus	76-79
18368618-12	2008	The observed acute pulmonary toxicity of TP could be due to the presence of water soluble Zn and Cu.	Water	76-81	transition protein 2	Rattus norvegicus	41-43
33788103-1	2021	Glucagon-like peptide-1 (GLP-1), a product of partial proteolysis of proglucagon, is involved not only in regulation of carbohydrates, but also in water-salt metabolism.	Water	147-152	glucagon	Rattus norvegicus	0-23
17661357-1	2008	Aquaporin8 (AQP8) is a transmembrane water channel that is found mainly in hepatocytes.	Water	37-42	aquaporin 8	Gallus gallus	0-10
17661357-1	2008	Aquaporin8 (AQP8) is a transmembrane water channel that is found mainly in hepatocytes.	Water	37-42	aquaporin 8	Gallus gallus	12-16
19068326-6	2008	The proposed fluorescence optode was successfully applied to the determination of cobalt content of vitamin B12 ampoule, cobalt cake, cobalt alloy and tap water samples.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	151-154
18842831-0	2008	Does the intracellular ionic concentration or the cell water content (cell volume) determine the activity of TonEBP in NIH3T3 cells?	Water	55-60	nuclear factor of activated T cells 5	Mus musculus	109-115
17410115-3	2008	To examine the accuracy of a nitrate/nitrite test strip, we recruited Washington State residents to estimate levels of these contaminants in their tap water using these strips, and simultaneously provide a tap water sample for laboratory analysis.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
33788103-1	2021	Glucagon-like peptide-1 (GLP-1), a product of partial proteolysis of proglucagon, is involved not only in regulation of carbohydrates, but also in water-salt metabolism.	Water	147-152	glucagon	Rattus norvegicus	25-30
33788103-3	2021	Of them, only blood plasma GLP-1 increased in response to water load (20 ml/kg).	Water	58-63	glucagon	Rattus norvegicus	27-32
18408264-4	2008	The water samples in the study were of two types, viz, borewell water and tap water, these being commonly used by the people of Davangere City, Karnataka.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	74-77
33788103-5	2021	GLP-1 accelerated excretion of excess water during hyperhydration, whereas GLP-2 decreased this parameter.	Water	38-43	glucagon	Rattus norvegicus	0-5
33650048-2	2021	The objectives of this study were to determine if the levels of serum CC16 and MMP-9 and subsequent respiratory infections in children are associated with the ingestion of arsenic by drinking water.	Water	192-197	matrix metallopeptidase 9	Homo sapiens	79-84
20200594-5	2008	Results showed that the PLN cell proliferation of mice treated with anti-CTLA-4 mAb and IL-18 remained significantly suppressed compared with water-fed controls, while a partial abrogation of suppressed IL-4 and IFN-gamma levels were observed.	Water	142-147	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	73-79
18680101-5	2008	Molecular dynamic simulation of the (Gd-DO3A-AEEA)16-PDAP4-AEEA2-KRAS PNA-AEEA-D(Cys-Ser-Lys-Cys) genetic imaging nanoparticles in explicit water yielded a pair correlation function similar to that of PAMAM dendrimers, and a predicted structure in which the PDAP dendron did not sequester the PNA.	Water	140-145	KRAS proto-oncogene, GTPase	Homo sapiens	65-69
18790850-4	2008	In general, the CPAIMD (B-LYP) simulations predict a simplified structural model of proline/water mixtures consisting of fewer distinct local motifs.	Water	92-97	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	26-29
33650048-7	2021	Increased arsenic concentrations in drinking water and average daily arsenic intake by water were associated with decreased serum CC16 levels (beta = - 0.12, 95% CI - 0.20, - 0.04 and beta = - 0.10, 95% CI - 0.18, - 0.03), and increased serum MMP-9 levels (beta = 0.35, 95% CI 0.22, 0.48 and beta = 0.29, 95% CI 0.18, 0.40) at significant levels (P < 0.05).	Water	87-92	matrix metallopeptidase 9	Homo sapiens	243-248
18275109-0	2008	Sensitivity enhancement for the analysis of naproxen in tap water by solid-phase extraction coupled in-line to capillary electrophoresis.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
33650048-10	2021	In conclusion, altered levels of serum CC16 and MMP-9 in the children may be due to the toxic effects of arsenic exposure through drinking water.	Water	139-144	matrix metallopeptidase 9	Homo sapiens	48-53
18275109-1	2008	SPE coupled in-line to CE, as the strategy to enhance the concentration sensitivity in CE, has been used to enrich naproxen in tap water samples.	Water	131-136	nuclear RNA export factor 1	Homo sapiens	127-130
18649401-3	2008	In this study, we differentiated primary astrocyte cultures with cAMP and lovastatin, both able to induce glial stellation through a reorganization of F-actin cytoskeleton, and obtained AQP4 selectively localized on the cell plasma membrane associated with an increase in the plasma membrane water transport level, but only cAMP induced an increase in AQP4 total protein expression.	Water	292-297	aquaporin 4	Homo sapiens	186-190
33128701-0	2021	Rotavirus Surveillance in Tap Water, Recycled Water, and Sewage Sludge in Thailand: A Longitudinal Study, 2007-2018.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
19256380-10	2008	In the third stage, raw leachate was diluted by tap water in order to decrease the FA concentration.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
17998610-9	2008	Previous surveys in England and Korea have shown that acanthamoebae are found in 15 to 30% of tap water samples in the home and have been associated with corneal infection in contact lens wearers.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
33128701-1	2021	The objective of this study was to describe the epidemiological and molecular surveillance of rotaviruses in tap water, recycled water, and sewage sludge in Thailand from 2007 to 2018.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
33465449-13	2021	CLINICAL SIGNIFICANCE: Drinking fluoridated tap water is as effective in dental caries prevention as bottled water with acceptable levels of fluoride, with the advantage of being accessible to all.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
17604908-7	2008	However, at higher pH (pH&gt;5), the presence of GPS decreased the adsorption of Zn on goethite, because GPS reacted with solution Zn to form water-soluble complexes that had lower affinity to the goethite surface in comparison with Zn itself.	Water	142-147	neurobeachin like 2	Homo sapiens	49-52
17604908-7	2008	However, at higher pH (pH&gt;5), the presence of GPS decreased the adsorption of Zn on goethite, because GPS reacted with solution Zn to form water-soluble complexes that had lower affinity to the goethite surface in comparison with Zn itself.	Water	142-147	neurobeachin like 2	Homo sapiens	105-108
18648381-3	2008	The perivascular pool of AQP4 is important in the influx and efflux of water during focal cerebral ischemia.	Water	71-76	aquaporin 4	Mus musculus	25-29
33248184-0	2021	The Antidepressant-Like Effects of the water extract of Panax ginseng and Polygala tenuifolia are mediated via the BDNF-TrkB Signaling Pathway and Neurogenesis in the Hippocampus.	Water	39-44	brain-derived neurotrophic factor	Rattus norvegicus	115-119
17602312-1	2008	Asr1 and Asr2 are water stress-inducible genes belonging to the Asr gene family, which transcriptionally regulate a sugar transporter gene, at least in grape.	Water	18-23	abscisic stress-ripening protein 1	Solanum lycopersicum	0-4
18048366-6	2008	The hypothesis that Sln1p kinase activity is responsive to turgor was first suggested by the increased Sln1p kinase activity in mutants lacking Fps1p in which glycerol accumulation leads to water uptake.	Water	190-195	Fps1p	Saccharomyces cerevisiae S288C	144-149
18536011-8	2008	The water-mediated R30-D404 salt bridge is thought to be part of the extracellular (EC) gate of LeuT.	Water	4-9	Leucine transport, high	Homo sapiens	96-100
33746392-6	2021	Results revealed that risk factors including drinking tap water and attendance of nurseries, affected the rate of parasitic infection among humans.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
18536011-9	2008	The introduction of a polar ligand such as glycine to the water-depleted binding pocket of LeuT gives rise to structural rearrangements of the R30-D404-Q250 hydrogen-bonding network and leads to increased hydration of the binding pocket.	Water	58-63	Leucine transport, high	Homo sapiens	91-95
18171940-0	2008	Vasopressin increases locomotion through a V1a receptor in orexin/hypocretin neurons: implications for water homeostasis.	Water	103-108	arginine vasopressin receptor 1A	Mus musculus	43-55
18929386-7	2008	Biosorption studies indicated that SRB cell pellets removed about 6.6% of the As(III) and 10.5% of the As(V) from water containing an initial concentration of 1mg/L of either arsenic species after 24h contact.	Water	114-119	chaperonin containing TCP1 subunit 4	Homo sapiens	35-38
18986671-0	2008	Photooxidation and subsequent biodegradability of recalcitrant tri-alkyl phosphates TCEP and TBP in water.	Water	100-105	TATA-box binding protein	Homo sapiens	93-96
19388360-14	2008	These data provide further support that vasopressin (AVP) and V1a receptors can control water flux through astrocytic plasma membranes by regulating AQP4 expression.	Water	88-93	arginine vasopressin receptor 1A	Rattus norvegicus	62-65
33644198-13	2021	CONCLUSION: The TEP1 (rs938886), TEP1 (rs1713449), and RECQL5 (rs820196) SNPs were associated with changes in heart rate >= 30% during intraperitoneal lavage using distilled water after gastrectomy for gastric cancer.	Water	174-179	telomerase associated protein 1	Homo sapiens	16-20
18245965-5	2008	RESULTS: Eyes irrigated with PSS with chlorine showed an increase in fluorescein scores, and eyes washed with both tap water and PSS with chlorine showed an increase in Rose Bengal scores.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
18274967-1	2008	The Bowman-Birk inhibitor (BBI) is a small water-soluble protein present in soybean and almost all monocotyledonous and dicotyledonous seeds.	Water	43-48	Bowman-Birk type proteinase inhibitor	Glycine max	4-25
33593893-4	2021	Here we show that the synaptic architecture of hippocampal regions CA1 and CA3 is maintained in a young adult-like state in aged rats that performed comparably to their young adult counterparts in both trace eyeblink conditioning and Morris water maze learning.	Water	241-246	carbonic anhydrase 3	Rattus norvegicus	75-78
18274967-1	2008	The Bowman-Birk inhibitor (BBI) is a small water-soluble protein present in soybean and almost all monocotyledonous and dicotyledonous seeds.	Water	43-48	Bowman-Birk type proteinase inhibitor	Glycine max	27-30
18274967-5	2008	BBI is stable within the pH range encountered in most foods, can withstand boiling water temperature for 10 min, resistant to the pH range and proteolytic enzymes of the gastrointestinal tract, bioavailable, and not allergenic.	Water	83-88	Bowman-Birk type proteinase inhibitor	Glycine max	0-3
18977225-4	2008	In contrast to the structure of the human SULT1A3 (hSULT1A3)-dopamine complex previously reported, molecular modeling and mutational analysis revealed that a water molecule plays a critical role in the recognition of the amine group of dopamine by mSULT1D1.	Water	158-163	sulfotransferase family 1A member 3	Homo sapiens	42-49
18977225-4	2008	In contrast to the structure of the human SULT1A3 (hSULT1A3)-dopamine complex previously reported, molecular modeling and mutational analysis revealed that a water molecule plays a critical role in the recognition of the amine group of dopamine by mSULT1D1.	Water	158-163	sulfotransferase family 1A member 3	Homo sapiens	51-59
17804070-10	2008	The aac(3)-II gene was detected both in patient and waste water isolates.	Water	58-63	aminoglycoside N(3')-acetyltransferase III	Escherichia coli	4-13
18708027-1	2008	Evidence that membrane surface tension regulates water fluxes in intact cells of a Saccharomyces cerevisiae strain overexpressing aquaporin AQY1 was obtained by assessing the osmotic water transport parameters in cells equilibrated in different osmolarities.	Water	49-54	Aqy1p	Saccharomyces cerevisiae S288C	140-144
33427846-3	2021	Herein, beta-phase anhydrous guanine (beta-AG) microrods were formed in mixed solvents of formamide and water in the presence of small organic molecules such as uric acid, pyrrole (Py), N-methyl-2-pyrrolidone (NMP), N-vinyl-2-pyrrolidone (NVP).	Water	104-109	N-methylpurine DNA glycosylase	Homo sapiens	38-45
18708027-1	2008	Evidence that membrane surface tension regulates water fluxes in intact cells of a Saccharomyces cerevisiae strain overexpressing aquaporin AQY1 was obtained by assessing the osmotic water transport parameters in cells equilibrated in different osmolarities.	Water	183-188	Aqy1p	Saccharomyces cerevisiae S288C	140-144
18708027-2	2008	The osmotic water permeability coefficients (P(f)) obtained for yeast cells overexpressing AQY1 incubated in low osmolarity buffers were similar to those obtained for a double mutant aqy1aqy2 and approximately three times lower (with higher activation energy, E(a)) than values obtained for cells incubated in higher osmolarities (with lower E(a)).	Water	12-17	Aqy1p	Saccharomyces cerevisiae S288C	91-95
17804070-11	2008	Furthermore horizontal transfer of the aac(3)-II gene of patient origin to a recipient was shown in vitro, indicating a potential spread of the gene from patient isolates to waste water isolates.	Water	180-185	aminoglycoside N(3')-acetyltransferase III	Escherichia coli	39-48
17804070-13	2008	In conclusion, our study showed a possible spread of aac(3)-II from the hospital to the waste water.	Water	94-99	aminoglycoside N(3')-acetyltransferase III	Escherichia coli	53-62
18842284-4	2008	BDE-47 photodegradation all well followed pseudo-first-order kinetics under various conditions, and the decay rate was 0.4-1.3 times greater in the presence of surfactants than that in water alone.	Water	185-190	homeobox D13	Homo sapiens	0-3
17965434-1	2008	In this study, we analyzed a water-soluble polysaccharide MP-I isolated from Mytilus coruscus.	Water	29-34	mannose phosphate isomerase	Mus musculus	58-62
33427846-4	2021	The one-dimensional (1D) assembly of beta-AG microrods form spontaneously in water, which is the first reported highly ordered 1D assembly of organic micro- or nanocrystals in the solution.	Water	77-82	N-methylpurine DNA glycosylase	Homo sapiens	37-44
17965434-2	2008	MP-I was obtained by hot-water extraction, anion-exchange and gel-permeation chromatography.	Water	25-30	mannose phosphate isomerase	Mus musculus	0-4
33427846-5	2021	The obtained beta-AG microrods obtained in Py system can form reversible 1D assembly in water after being treated in organic solvents such as ethanol, acetone and isopropanol, which have high solubility in water.	Water	88-93	N-methylpurine DNA glycosylase	Homo sapiens	13-20
33427846-5	2021	The obtained beta-AG microrods obtained in Py system can form reversible 1D assembly in water after being treated in organic solvents such as ethanol, acetone and isopropanol, which have high solubility in water.	Water	206-211	N-methylpurine DNA glycosylase	Homo sapiens	13-20
18614997-6	2008	The physiological relevance of our in vitro data was confirmed by water deprivation of male C57BL6 mice, which caused a significant increase in serum osmolality along with induction of CLC-K1, barttin and SGK1.	Water	66-71	barttin CLCNK type accessory beta subunit	Mus musculus	193-200
18491065-5	2008	Disruption of AKAP functions by gene targeting, knockdown approaches and, in particular, pharmacological disruption of defined AKAP-dependent protein-protein interactions has revealed key roles of AKAPs in numerous processes, including the regulation of cardiac myocyte contractility and vasopressin-mediated water reabsorption in the kidney.	Water	309-314	A-kinase anchoring protein 1	Homo sapiens	14-18
33427846-8	2021	The reversible 1D assemblies of guanine microrods in water and organic solvents with high solubility in water indicate that there is a strong interaction between the (100) planes of beta-AG microrods in water.	Water	53-58	N-methylpurine DNA glycosylase	Homo sapiens	182-189
18491065-5	2008	Disruption of AKAP functions by gene targeting, knockdown approaches and, in particular, pharmacological disruption of defined AKAP-dependent protein-protein interactions has revealed key roles of AKAPs in numerous processes, including the regulation of cardiac myocyte contractility and vasopressin-mediated water reabsorption in the kidney.	Water	309-314	A-kinase anchoring protein 1	Homo sapiens	127-131
33427846-8	2021	The reversible 1D assemblies of guanine microrods in water and organic solvents with high solubility in water indicate that there is a strong interaction between the (100) planes of beta-AG microrods in water.	Water	104-109	N-methylpurine DNA glycosylase	Homo sapiens	182-189
18441928-3	2008	The efficiency of calcite barrier to control phosphorus release from sediments will increase with the increment of Ca2+ concentration of overlying water and barrier thickness.	Water	147-152	carbonic anhydrase 2	Homo sapiens	115-118
33427846-8	2021	The reversible 1D assemblies of guanine microrods in water and organic solvents with high solubility in water indicate that there is a strong interaction between the (100) planes of beta-AG microrods in water.	Water	104-109	N-methylpurine DNA glycosylase	Homo sapiens	182-189
18441928-5	2008	When the Ca2+ concentration of overlying water increased from 1 mmol/L to 5 mmol/L, the phosphorus concentration was reduced by about 36% in the 72nd day.	Water	41-46	carbonic anhydrase 2	Homo sapiens	9-12
33279751-8	2021	Results of the study show that residual dissolved Al in coagulated water can be controlled by affecting theAl binding sites in DOM by pre-oxidation before coagulation.	Water	67-72	acyl-CoA thioesterase 12	Homo sapiens	104-109
18536508-1	2008	To prevent formation of trihalomethanes (THMs) in drinking water, removing precursors of trihalomethanes (PTHMs) in water resources for tap water is essential.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	136-139
18956456-2	2008	The PCA2-switch agent incorporates a solubility switch, where cleavage of a peptide substrate by MMP-2 decreases the water solubility of the agent.	Water	117-122	matrix metallopeptidase 2	Mus musculus	97-102
33265044-0	2021	Combined effects of seasonality and stagnation on tap water quality: Changes in chemical parameters, metabolic activity and co-existence in bacterial community.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
18607643-3	2008	In this study, we demonstrate that Stx2 and its B subunit (Stx2B) were able to inhibit water absorption across human renal tubular epithelial cell (HRTEC) monolayers without altering the short circuit current and the (3)H-mannitol permeability.	Water	87-92	syntaxin 2	Homo sapiens	59-64
18607643-6	2008	Our findings suggest that whereas the action of Stx2 appears to be caused mainly by the inhibition of protein synthesis mediated by the A subunit, the binding of Stx2B subunit to the Gb3 receptor may affect the membrane mechanisms related to water absorption.	Water	242-247	syntaxin 2	Homo sapiens	162-167
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Water	17-22	limit dextrinase	Arabidopsis thaliana	102-105
18663893-2	2008	Radon released from water into the ambient atmosphere is a source of health hazard to the workers handling mineral water in Spa facilities.	Water	20-25	surfactant protein A2	Homo sapiens	124-127
18655912-6	2008	AQP4 deficient astroglial cells show greatly impaired migration in response to chemotactic stimuli, reducing glial scar formation, by a mechanism that we propose involves AQP4-facilitated water flux in lamellipodia of migrating cells.	Water	188-193	aquaporin 4	Mus musculus	0-4
18655912-6	2008	AQP4 deficient astroglial cells show greatly impaired migration in response to chemotactic stimuli, reducing glial scar formation, by a mechanism that we propose involves AQP4-facilitated water flux in lamellipodia of migrating cells.	Water	188-193	aquaporin 4	Mus musculus	171-175
33265044-1	2021	In drinking water distribution pipeline systems, the tap water quality is regulated by several biotic and abiotic factors, which can threaten the health of consumers.	Water	12-17	nuclear RNA export factor 1	Homo sapiens	53-56
18821542-3	2008	Herein, we systemically investigated the interaction between chaperonin GroEL and water-soluble CdTe QDs based on fluorescence correlation spectroscopy (FCS), capillary electrophoresis, and fluorescence spectrometry.	Water	82-87	heat shock protein family D (Hsp60) member 1	Homo sapiens	72-77
18821542-4	2008	We observed that some water-soluble CdTe QDs were able to enter the inner cavity of GroEL and formed an inclusion complex after the activation of chaperonin GroEL with ATP.	Water	22-27	heat shock protein family D (Hsp60) member 1	Homo sapiens	84-89
33265044-1	2021	In drinking water distribution pipeline systems, the tap water quality is regulated by several biotic and abiotic factors, which can threaten the health of consumers.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
18821542-4	2008	We observed that some water-soluble CdTe QDs were able to enter the inner cavity of GroEL and formed an inclusion complex after the activation of chaperonin GroEL with ATP.	Water	22-27	heat shock protein family D (Hsp60) member 1	Homo sapiens	157-162
33265044-2	2021	Stagnation is inevitable in the water distribution pipeline however, the combined effects of seasonal changes and stagnation on tap water quality are not well understood.	Water	132-137	nuclear RNA export factor 1	Homo sapiens	128-131
18054802-4	2008	AQP4, found in astrocyte foot processes, glia limitans and ependyma, facilitates water movement into and out of the brain, accelerates astrocyte migration and alters neuronal activity.	Water	81-86	aquaporin 4	Homo sapiens	0-4
18838545-2	2008	This autoantibody targets astrocytic aquaporin-4 (AQP4) water channels.	Water	56-61	aquaporin 4	Homo sapiens	37-48
33265044-4	2021	The results showed that the tap water quality deteriorated after overnight stagnation, with up to a 2.7-fold increase in the total iron concentrations.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
18838545-2	2008	This autoantibody targets astrocytic aquaporin-4 (AQP4) water channels.	Water	56-61	aquaporin 4	Homo sapiens	50-54
33265044-12	2021	Altogether, the overall findings from the present work provide novel insights into how the quality of tap water quality impacted by the seasonal changes and overnight stagnation.	Water	106-111	nuclear RNA export factor 1	Homo sapiens	102-105
33534126-6	2021	Naringin treatment for 14 days attenuated Abeta-induced cognitive impairments of the animals in Morris water maze (MWM) and Y-maze tests.	Water	103-108	amyloid beta precursor protein	Rattus norvegicus	42-47
18936997-18	2008	Filter residues of native water caused increased AhR-mediated activity at the peak of the flood.	Water	26-31	LOC522736	Bos taurus	49-52
19092219-5	2008	At the markets, although the tap water was found to be free of microbes, contaminated and non-contaminated vegetables are mixed and washed in the same bowl, which may bring about further spreading of infectious bacteria.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
18441443-5	2008	Concerning the financial part, the implementation of membrane processes in the wastewater purification installation is economically feasible, especially when expensive tap water is used as pure water.	Water	172-177	nuclear RNA export factor 1	Homo sapiens	168-171
32920270-5	2021	SlPG2, SlEXP1, and SlCEL2 mRNAs accumulation was reduced in OG-elicited tomato fruit compared to water-treated fruit with subsequent retardation of the fruit softening during ripening.	Water	97-102	polygalacturonase-2	Solanum lycopersicum	0-5
18418974-8	2008	CONCLUSION: Both HEB and RR, in dosage-form of water decoction, could up-regulate the protein expression and binding power of GR in GR down-regulated model rats, but different in acting time.	Water	47-52	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	126-128
18418974-8	2008	CONCLUSION: Both HEB and RR, in dosage-form of water decoction, could up-regulate the protein expression and binding power of GR in GR down-regulated model rats, but different in acting time.	Water	47-52	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	132-134
18606223-5	2008	Drugs with higher solubility in water were released faster for the CR-A.	Water	32-37	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	67-71
18791465-2	2008	The sEH inhibitor, 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea (AEPU) was delivered in drinking water.	Water	106-111	epoxide hydrolase 2, cytoplasmic	Mus musculus	4-7
33401097-9	2021	The results supported the role of the AtAREB1 gene in conferring tolerance to water deficit in soybeans.	Water	78-83	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	38-45
18052134-4	2007	The calculated results suggest a proton-transferred hydrogen bond between HO2 and H2O in H3O3+ wherein a proton is partially transferred to H2O producing the O2...H3O+ structure.	Water	82-85	H3 clustered histone 15	Homo sapiens	89-92
33394314-5	2021	By crossing with VegftetO/tetO mice, that has tetracycline operator sequences insertion in 5"-UTR region, it allows us to reversibly inhibit lung VEGF transcription from its endogenous level through doxycycline food, water or injection.	Water	217-222	vascular endothelial growth factor A	Mus musculus	146-150
17369110-5	2007	AQP1 and AQP5 provide the principal route for osmotically driven water transport between airspace and capillary compartments; however, alveolar fluid clearance in the neonatal and adult lung is not affected by their deletion, nor is lung fluid accumulation in experimental models of lung injury.	Water	65-70	aquaporin 5	Mus musculus	9-13
17369110-6	2007	In the airways, though AQP3 and AQP4 facilitate osmotic water transport, their deletion does not impair airway hydration, regulation of airway surface liquid, or fluid absorption.	Water	56-61	aquaporin 4	Mus musculus	32-36
18767815-11	2008	Together, the data support the argument that wild-type Ngb is protected from attack by H 2O 2 by the coordinated distal His.	Water	87-91	neuroglobin	Homo sapiens	55-58
33279831-0	2021	Application of Capsid Integrity (RT-)qPCR to Assessing Occurrence of Intact Viruses in Surface Water and Tap Water in Japan.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	105-108
33279831-6	2021	In the tap water samples, most of the target viruses were not detected by conventional (RT-)qPCR, except for PMMoV (9%) and AiV (5%).	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
19176113-3	2008	Eighty Lewis rats were immunized with interphotoreceptor retinoid-binding protein (IRBP) to induce EAU.	Water	99-102	retinol binding protein 3	Rattus norvegicus	38-81
33279831-9	2021	In addition to being abundant in surface water, PMMoV was detected in tap water, including PMMoV with intact capsids.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
19176113-3	2008	Eighty Lewis rats were immunized with interphotoreceptor retinoid-binding protein (IRBP) to induce EAU.	Water	99-102	retinol binding protein 3	Rattus norvegicus	83-87
17994749-11	2007	A specific example, which is not consistent with rigorous selection of functional RNAs or RNA cognates, is provided by the precipitation of the water-insoluble precursor, tris(dibenzylideneacetone) dipalladium(0) Pd2(DBA)3.	Water	144-149	ribosomal protein S24	Homo sapiens	213-222
33279831-10	2021	Thus, the absence of intact PMMoV may be used to guarantee the viral safety of tap water produced from surface water.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
33279831-10	2021	Thus, the absence of intact PMMoV may be used to guarantee the viral safety of tap water produced from surface water.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	79-82
33514305-6	2021	In conclusion, DRA mediates Cl- absorption and HCO3- secretion in the mouse cecum and middle-distal colon, and may have roles in H2O absorption and luminal acid/base regulation in these segments.	Water	129-132	solute carrier family 26, member 3	Mus musculus	15-18
17943710-2	2007	The proposed force-field is derived to reproduce densities, self-diffusion coefficients for cations and ions as well as NMR rotational correlation times for cations and water molecules in [C(2)mim][NTf2].	Water	169-174	nuclear transport factor 2	Homo sapiens	198-202
18571218-1	2008	This study was conducted to compare housewives" winter and summer exposures to volatile disinfection by-products (DBPs) in chlorinated tap water.	Water	139-144	nuclear RNA export factor 1	Homo sapiens	135-138
18571218-5	2008	All of the subjects answered that they consumed tap water after either thermal treatment or purification through filtration systems.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
18571218-8	2008	In both seasons, the ingestion route can be discounted, because tap water is processed before consumption, eliminating the volatile DBPs.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
32879162-6	2021	In this study, we developed a mouse model of chronic SIADH in which stable and sustained hyponatremia occurred after 3-week continuous infusion of the vasopressin V2 receptor agonist 1-desamino-8-D-arginine vasopressin (dDAVP) and liquid diet feeding to produce chronic water loading.	Water	270-275	arginine vasopressin receptor 2	Mus musculus	151-174
18710231-2	2008	Here, we combine all-atom molecular dynamics simulations with data from experimental assays of the activity of the bacterial chaperonin GroEL to demonstrate that a chaperonin"s ability to facilitate folding is correlated with the affinity of its interior surface for water.	Water	267-272	heat shock protein family D (Hsp60) member 1	Homo sapiens	136-141
17653723-0	2007	Stress-inducible expression of At DREB1A in transgenic peanut (Arachis hypogaea L.) increases transpiration efficiency under water-limiting conditions.	Water	125-130	dehydration response element B1A	Arabidopsis thaliana	34-40
17689184-4	2007	Column tests were carried out to investigate the removal of arsenate from tap water under dynamic conditions.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
33525658-2	2021	Water-soluble linear and cholesterol-containing HPMA precursors were synthesized using controlled reversible addition-fragmentation chain transfer polymerization to reach molecular weight Mn about 2 x 104 g mol-1 and low dispersity.	Water	0-5	modifier of LPS-response 1	Mus musculus	207-212
18683931-1	2008	Combining information from time-resolved X-ray and neutron scattering with theoretical calculations has revealed the elegant mechanism whereby hydrogen crystalline silicotitanate (H-CST; H2Ti2SiO7 x 1.5 H2O) achieves its remarkable ion-exchange selectivity for cesium.	Water	203-206	cystatin 12, pseudogene	Homo sapiens	182-185
17727915-2	2007	Concentrations of substances in these livestock products are often estimated using log-log regressions that relate the biotransfer factor BTF to the octanol-water partition ratio K(ow).	Water	157-162	BCL2 associated transcription factor 1	Homo sapiens	138-141
33513980-10	2021	This model can reflect the hydration characteristics of C3A in different stages, and quantify the response of the hydration process of C3A to different gypsum content, water-cement ratio, and particle size distribution.	Water	168-173	complement C3	Homo sapiens	135-138
18392839-1	2008	Transmembrane water transport is mediated by aquaporins (AQPs), of which AQP1 and AQP4 are expressed in skeletal muscle.	Water	14-19	aquaporin 4	Homo sapiens	82-86
33483878-2	2022	KOR agonist-induced diuresis is characterized as water diuresis, in which water excretion with urine is increased without altering electrolyte excretion.	Water	49-54	opioid receptor kappa 1	Homo sapiens	0-3
18635449-11	2008	After lateral PBN lesions, the Fos distributions produced by distilled H(2)O or sucrose intake did not differ from controls.	Water	71-76	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-34
22443825-5	2008	Leptin and insulin concentrations were lower (1.4 +- 0.09 v. 1.5 +- 0.12 ng/ml; (P &lt; 0.05) and 7.2 +- 0.55 v. 8.2 +- 0.83 ng/ml; P &lt; 0.02) in response to high-salt ingestion as was aldosterone concentration (27 +- 2.7 v. 49 +- 5.4 pg/ml; P &lt; 0.05), presumably to achieve salt and water homeostasis.	Water	289-294	LOC105613195	Ovis aries	11-18
17644445-1	2007	Here, I investigate features of the heat-shock protein beta1 (HspB1) that may be unique to cold-water fish.	Water	96-101	heat shock protein, alpha-crystallin-related, 1	Oncorhynchus mykiss	62-67
18260405-1	2007	The present paper introuduces the method, with which the water-soluble polysaccharide was extracted with hot water from Garidi-15, the products were further purified with column chromatography on SephadexC-25, and the contents of water soluble polysaccharide were determined by phenyl hydrate-sulfuric acid method.	Water	57-62	alcohol dehydrogenase iron containing 1	Homo sapiens	105-108
18260405-1	2007	The present paper introuduces the method, with which the water-soluble polysaccharide was extracted with hot water from Garidi-15, the products were further purified with column chromatography on SephadexC-25, and the contents of water soluble polysaccharide were determined by phenyl hydrate-sulfuric acid method.	Water	109-114	alcohol dehydrogenase iron containing 1	Homo sapiens	105-108
17890008-2	2007	The aquaporin 4 (AQP4) water channel is abundant in mammalian brain and there is a growing body of evidence suggesting that this protein plays a major role in the control of water flow within the central nervous system.	Water	174-179	aquaporin 4	Homo sapiens	4-15
17890008-2	2007	The aquaporin 4 (AQP4) water channel is abundant in mammalian brain and there is a growing body of evidence suggesting that this protein plays a major role in the control of water flow within the central nervous system.	Water	174-179	aquaporin 4	Homo sapiens	17-21
33483878-2	2022	KOR agonist-induced diuresis is characterized as water diuresis, in which water excretion with urine is increased without altering electrolyte excretion.	Water	74-79	opioid receptor kappa 1	Homo sapiens	0-3
33483878-6	2022	The therapeutic potentials of KOR agonists as water diuretics have been studied in animal models of cerebral edema due to ischemia and intracranial mass, hypertension, and cirrhosis.	Water	46-51	opioid receptor kappa 1	Homo sapiens	30-33
33551725-7	2020	In contrast, if they self-stimulated near the less palatable stimulus, some VGAT-ChR2 mice preferred water over 18% sucrose.	Water	101-106	solute carrier family 32 (GABA vesicular transporter), member 1	Mus musculus	76-80
18058718-8	2007	The secondary structure analysis of PIF/DCD native protein in aqueous solution, by circular dichroism spectroscopy, revealed regions with non-well-defined secondary structure but that acquired alpha-helix and beta-sheet secondary structures in the presence of TFE/water mixtures and micellar and non-micellar SDS molecules.	Water	264-269	dermcidin	Homo sapiens	36-39
19138973-6	2008	At sacrifice, drinking water with EGCG caused a significant decrease in the number of total aberrant crypt foci, large aberrant crypt foci, and beta-catenin accumulated crypts in these mice, all of which are premalignant lesions of the colon.	Water	23-28	catenin (cadherin associated protein), beta 1	Mus musculus	144-156
18679106-2	2008	We tested the hypothesis that hypertonic saline exerts its antiedema effect by promoting an efflux of water from brain via the perivascular aquaporin-4 pool.	Water	102-107	aquaporin 4	Mus musculus	140-151
17492301-13	2007	Tap water is also effective as a rinsing solution.	Water	4-9	putative ABC-transporter	Sus scrofa	0-3
33499944-2	2021	Aquaporin-4 water channels (AQP4) are an integral part of this system and related to neuropathologies, such as Alzheimer"s disease (AD).	Water	12-17	aquaporin 4	Homo sapiens	0-11
18850657-6	2008	This method was successfully applied to separate MCs from other compounds in spiked tap water after solid-phase extraction.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
33499944-2	2021	Aquaporin-4 water channels (AQP4) are an integral part of this system and related to neuropathologies, such as Alzheimer"s disease (AD).	Water	12-17	aquaporin 4	Homo sapiens	28-32
32991925-7	2021	We found that TREM2 shRNA injection can improve learning and memory ability in elderly mice, as demonstrated by improved learning ability and memory performance in the Morris water maze (MWM) test, an increased freezing duration in the contextual fear conditioning test, a higher preference ratio in the novel object recognition (NOR) test and a higher alternation rate in the T-maze test.	Water	175-180	triggering receptor expressed on myeloid cells 2	Mus musculus	14-19
18537141-8	2008	The developmental defects in the ENS of noggin-overexpressing mice caused a relatively mild disturbance of motility (irregular rapid transit and increased stool frequency, weight, and water content).	Water	184-189	noggin	Mus musculus	40-46
18698916-1	2008	Thermodynamic, structural, and dynamic properties of heavy water (D(2)O) confined in mesoporous silica glass MCM-41 C10, C12, and C14 were investigated by differential scanning calorimetry, neutron diffraction, and neutron spin echo (NSE) measurements, respectively.	Water	59-64	chromosome 12 open reading frame 57	Homo sapiens	116-119
17902103-2	2007	In the present work, evidence is provided from (18)[(1)O(2)] and H(2) (18)O labeling experiments, using HPLC-ESI-MS/MS, that the formation of dSp is explained by the addition of water to a reactive quinonoid intermediate, and a second reaction pathway leading to dSp involves (1)O(2) oxidation of initially generated 8-oxodGuo.	Water	178-183	dsp	Drosophila melanogaster	142-145
17902103-2	2007	In the present work, evidence is provided from (18)[(1)O(2)] and H(2) (18)O labeling experiments, using HPLC-ESI-MS/MS, that the formation of dSp is explained by the addition of water to a reactive quinonoid intermediate, and a second reaction pathway leading to dSp involves (1)O(2) oxidation of initially generated 8-oxodGuo.	Water	178-183	dsp	Drosophila melanogaster	263-266
18698916-3	2008	For C10, the neutron radial distribution functions of confined D(2)O suggested a structural change in the supercooled state between 223 and 173 K. For C10 sample, it has been found that the tetrahedral-like water structure is partially enhanced in the central part of pores at 173 K. For all the samples, the intermediate scattering functions from the NSE measurements are fitted by the Kohlrausch-Williams-Watts stretched exponential function which implies that confined supercooled D(2)O exhibits a wide distribution of relaxation times.	Water	207-212	chromosome 12 open reading frame 57	Homo sapiens	4-7
32721640-8	2021	Besides, we also demonstrated that this system is able to detect PCB77 in tap water, environmental water and milk.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
18698916-3	2008	For C10, the neutron radial distribution functions of confined D(2)O suggested a structural change in the supercooled state between 223 and 173 K. For C10 sample, it has been found that the tetrahedral-like water structure is partially enhanced in the central part of pores at 173 K. For all the samples, the intermediate scattering functions from the NSE measurements are fitted by the Kohlrausch-Williams-Watts stretched exponential function which implies that confined supercooled D(2)O exhibits a wide distribution of relaxation times.	Water	207-212	chromosome 12 open reading frame 57	Homo sapiens	151-154
17764178-0	2007	Long distance electron-transfer mechanism in peptidylglycine alpha-hydroxylating monooxygenase: a perfect fitting for a water bridge.	Water	120-125	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	45-94
17678937-10	2007	Consequently, DC10-silica gel admicelles were the most adequate for concentrating chlorophenols in water.	Water	99-104	F-box protein 8	Homo sapiens	14-18
18602659-0	2008	Perfluorooctanesulfonate and perfluorooctanoate in raw and treated tap water from Osaka, Japan.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
18602659-8	2008	Concentration ranges of PFOS and PFOA in potable tap water were 0.16-22 ng/l and 2.3-84 ng/l, respectively.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
18602659-9	2008	There were positive correlations between PFC concentrations in raw water and tap water samples.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
33372797-3	2021	We demonstrate that the morphology, phase composition, and crystallinity of VNS/NF are well modulated by tuning the ratios of water/methanol solvent.	Water	126-131	neurofascin	Homo sapiens	80-82
18602659-11	2008	Based on the current action value reported by U.S. Environmental Protection Agency, PFOA concentrations found in tap water in Osaka is not expected to pose health risks.	Water	117-122	nuclear RNA export factor 1	Homo sapiens	113-116
17685635-6	2007	In the PEPCK-Mn2+-GTP structure, the same water molecule displaced by the C1 carboxylate of OAA is displaced by one of the gamma-phosphate oxygens of the triphosphate nucleotide.	Water	42-47	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	7-12
33372797-4	2021	The optimized VNS/NF-WM-heterostructured nanorod (volume ratio of water/methanol is 3:1) exhibits superior HER electrocatalytic activity with low overpotentials of 85 and 218 mV to yield current density values of 10 and 100 mA cm-2, respectively, meanwhile sustaining an excellent stability with almost an unchanged current density of 10 mA cm-2 for 60 h. Our work offers fresh insights into the rational design of highly active and stable earth-abundant-heterostructured electrocatalysts for the hydrogen fuel production.	Water	66-71	neurofascin	Homo sapiens	18-20
17691723-2	2007	Results indicate the formation of a nanoporous-like compound of hexagonal symmetry (space group P62) with large, water-filled channels running along the c axis.	Water	113-118	nucleoporin 62	Homo sapiens	96-99
33438270-4	2021	Overall, 81.5% of respondents reported daily well water consumption (i.e., tap water).	Water	50-55	nuclear RNA export factor 1	Homo sapiens	75-78
17990551-4	2007	The surface of titania whiskers is covered by the insoluble carbonates generated from carbon dioxide produced during the degradation of organics and metal ions such as calcium in the tap water, and the activity of the titania whiskers decreases gradually till deactivation.	Water	187-192	nuclear RNA export factor 1	Homo sapiens	183-186
18648056-7	2008	The results suggested that the acute premortem up-regulation of CORT decreased muscle ultimate pH by increasing the antemortem muscle glycogen content and its depletion rate postmortem, which in turn induced a decrease in water-holding capacity.	Water	222-227	CORT	Gallus gallus	64-68
33438270-4	2021	Overall, 81.5% of respondents reported daily well water consumption (i.e., tap water).	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
18632649-6	2008	We report here our experiences using a new approach based on Oscillating Gradient Spin-Echo (OGSE) MRI methods that can differentiate the influence on water diffusion of structural changes on scales much smaller than the diameter of a single cell.	Water	151-156	spindlin 1	Rattus norvegicus	82-86
17931065-0	2007	A pragmatic randomized controlled trial on the effectiveness of highly concentrated saline spa water baths followed by UVB compared to UVB only in moderate to severe psoriasis.	Water	95-100	surfactant protein A2	Homo sapiens	91-94
33442236-11	2021	Conclusion: Adenovirus-encoding sh-PBEF could reduce lung injury and repair the sodium-water transport system in rats receiving CPB, likely through reducing MAPK, ERK1/2, and Akt signaling pathways.	Water	87-92	nicotinamide phosphoribosyltransferase	Rattus norvegicus	35-39
17931065-2	2007	OBJECTIVE: The study aimed to evaluate whether highly concentrated saline spa water baths followed by UVB (HC-SSW-UVB) are superior to UVB only in moderate to severe psoriasis.	Water	78-83	surfactant protein A2	Homo sapiens	74-77
18178311-10	2008	It is concluded that ZFAs and high-calcium fly ashes may be promising materials for the purification of Cr(III) from water/wastewater.	Water	117-122	l(3)65ACc	Drosophila melanogaster	104-111
17714121-0	2007	A pragmatic randomized controlled trial on the effectiveness of low concentrated saline spa water baths followed by ultraviolet B (UVB) compared to UVB only in moderate to severe psoriasis.	Water	92-97	surfactant protein A2	Homo sapiens	88-91
33346661-1	2021	Chlorine radicals, including Cl  and Cl2 -, can be produced in sunlight waters (rivers, oceans, and lakes) or water treatment processes (e.g., electrochemical and advanced oxidation processes).	Water	72-77	endogenous retrovirus group W member 5	Homo sapiens	37-40
17938825-2	2007	These highly reactive species are formed from the reaction of hydrogen peroxide with redox metals such as copper, which are thought to be absorbed by the hair from the from-the-tap wash water.	Water	186-191	nuclear RNA export factor 1	Homo sapiens	177-180
18562499-5	2008	Recovery from activation was strongly dependent on PIP(2) acyl chain length, with channels exposed to water-soluble diC4 and diC8 showing much faster recovery than those exposed to PIP(2) (diC16).	Water	102-107	dynein axonemal intermediate chain 4	Homo sapiens	116-120
18330597-1	2008	We identified barley aquaporins and demonstrated that one, HvPIP2;1, transports water and CO2.	Water	80-85	HvPIP2;1	Hordeum vulgare	59-67
33346661-2	2021	Dissolved organic matter (DOM) is a major reactant with, or a scavenger of, Cl  and Cl2 - in water, but limited quantitative information exists regarding the influence of DOM structure on its reactivity with Cl  and Cl2 -.	Water	93-98	endogenous retrovirus group W member 5	Homo sapiens	84-87
17901544-5	2007	FABP increases this rate by increasing the solubility of fatty acids in water.	Water	72-77	fatty acid binding protein 2	Rattus norvegicus	0-4
32659589-7	2021	Nearly complete removal of 4-tBP (20 muM) was achieved after 5 min of reaction in both ultrapure water and natural waters, demonstrating the feasibility of this Fe(VI) oxidation method in treating phenols-contaminated waters.	Water	97-102	TATA-box binding protein	Homo sapiens	29-32
17688298-2	2007	A study of radioactivity content in tap water samples collected in the Central Italy was performed in order to check the compliance with recent European regulations.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
23572887-2	2008	Here we describe the reversibility of the vacuolar V-type H(+)-ATPase (V-ATPase) even in the absence of the H(+) gradient in a water-Me2SO co-solvent mixture, resulting in net synthesis of [gamma-(32)P]ATP from [(32)P]Pi and ADP.	Water	127-132	V-type proton ATPase catalytic subunit A	Zea mays	51-69
23572887-2	2008	Here we describe the reversibility of the vacuolar V-type H(+)-ATPase (V-ATPase) even in the absence of the H(+) gradient in a water-Me2SO co-solvent mixture, resulting in net synthesis of [gamma-(32)P]ATP from [(32)P]Pi and ADP.	Water	127-132	V-type proton ATPase catalytic subunit A	Zea mays	71-79
33146549-9	2021	Water intake also increased immunohistochemical and mRNA expressions of the ecto-nucleoside triphosphate diphosphohydrolase 2 and 5 in jejunal villi.	Water	0-5	ectonucleoside triphosphate diphosphohydrolase 2	Rattus norvegicus	76-131
18394669-7	2008	Induction of the MTF1 responsive genes, metallothionein-A (MTA), metallothionein-B (MTB), and zinc transporter 1 (ZnT-1) in the cell culture was strongly dependent of the concentrations of bioreactive zinc and silver in the test water.	Water	229-234	metallothionein A	Oncorhynchus mykiss	40-57
18476713-1	2008	The diarylprolinol ether/HOAc-catalyzed cascade Michael addition and cyclization of aldehydes and alpha-keto-alpha,beta-unsaturated esters proceeds smoothly in water to afford cyclic hemiacetals, which are oxidized to furnish highly functionalized 3,4,5,6-tetrasubstituted dihydropyrones with excellent enantioselectivities.	Water	160-165	hypoacusis 2 (autosomal recessive)	Homo sapiens	25-29
17574561-10	2007	The performance of the method was checked by analysis of river and tap water samples, and the relative recoveries of triazines from river and tap water at a spiking level of 5.0 microg L(-1) were 85.2-114.5% and 87.8-119.4%, respectively.	Water	146-151	nuclear RNA export factor 1	Homo sapiens	142-145
17637974-5	2007	The electronic and vibrational spectra of H3O(H2O)(n) clusters and the decay mechanism of these metastable species have been investigated in some detail.	Water	46-49	H3 clustered histone 15	Homo sapiens	42-45
17637974-6	2007	The results suggest that (H3O)(aq) could be the carrier of the characteristic spectroscopic properties of the hydrated electron in liquid water.	Water	138-143	H3 clustered histone 15	Homo sapiens	26-29
33197763-2	2021	The present study was designed to investigate the anti-fibrotic effect of water extracts of cbFeD in chronic liver injury mice model induced by carbon tetrachloride (CCl4) and to explore its underlying mechanisms.	Water	74-79	chemokine (C-C motif) ligand 4	Mus musculus	166-170
17431427-6	2007	MIA expression in vivo suppresses p66shc-stimulated increase in endogenous hydrogen peroxide (H(2)O(2)), and inhibits basal and H(2)O(2)-induced phosphorylation of p66shc on serine 36 and H(2)O(2)-induced death.	Water	94-99	src homology 2 domain-containing transforming protein C1	Mus musculus	34-40
33301078-2	2021	Up to 80% of NMOSD patients have a circulating pathogenic autoantibody that targets the water channel aquaporin-4 (AQP4-IgG).	Water	88-93	aquaporin 4	Homo sapiens	115-119
17549682-9	2007	Reintroducing either AQP1 or AQP4 stably into glioma cell lines allowed us to show that each AQP is sufficient to restore water permeability.	Water	122-127	aquaporin 4	Homo sapiens	29-33
17878689-4	2007	Rats fed LPD consumed 70-100% more Pi-water then those fed NPD.	Water	38-43	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	9-12
17878689-5	2007	The increase in Pi-water intake resulted in a marked rise in the growth rate of rats fed LPD during day 9.	Water	19-24	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	89-92
18188544-0	2008	Titania sol-gel-derived tyrosinase-based amperometric biosensor for determination of phenolic compounds in water samples.	Water	107-112	tyrosinase	Homo sapiens	24-34
18188544-2	2008	For detection of phenolic compounds in environmental water samples we propose an amperometric biosensor based on tyrosinase immobilized in titania sol-gel.	Water	53-58	tyrosinase	Homo sapiens	113-123
18472128-6	2008	Analysis of lake water samples collected at different depths showed the presence of HMX, RDX and PETN at concentrations from 0.1 to 0.4 ng l(-1).	Water	17-22	radixin	Homo sapiens	89-92
32854008-0	2021	Addition of lemon before boiling chlorinated tap water: A strategy to control halogenated disinfection byproducts.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
32854008-2	2021	A previous study has reported that the addition of ascorbate to tap water before boiling could significantly decrease the concentration of overall halo-DBPs in the boiled water.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
18356111-0	2008	Water-mediated interactions in the CRP-cAMP-DNA complex: does water mediate sequence-specific binding at the DNA primary-kink site?	Water	0-5	catabolite gene activator protein	Escherichia coli	35-38
17526733-1	2007	Cholera toxin (CT) produced by Vibrio cholerae causes the devastating diarrhea of cholera by catalyzing the ADP-ribosylation of the alpha subunit of the intestinal Gs protein (Gsalpha), leading to characteristic water and electrolyte losses.	Water	212-217	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	176-183
32854008-2	2021	A previous study has reported that the addition of ascorbate to tap water before boiling could significantly decrease the concentration of overall halo-DBPs in the boiled water.	Water	171-176	nuclear RNA export factor 1	Homo sapiens	64-67
18356111-0	2008	Water-mediated interactions in the CRP-cAMP-DNA complex: does water mediate sequence-specific binding at the DNA primary-kink site?	Water	62-67	catabolite gene activator protein	Escherichia coli	35-38
32854008-3	2021	Since the fruit lemon is rich in vitamin C (i.e., ascorbic acid), adding it to tap water followed by heating and boiling in an effort to decrease levels of halo-DBPs was investigated in this study.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
18356111-3	2008	In the current study, the possibility of contributions to indirect readout by water-mediated hydrogen bonding of CRP with the T:A base pair was investigated.	Water	78-83	catabolite gene activator protein	Escherichia coli	113-116
17479294-7	2007	However, during dry periods, most C(3) species used proportionally more water from deeper portions of the soil profile relative to the C(4) grasses.	Water	72-77	complement C3	Homo sapiens	34-38
32854008-6	2021	Our results show that the "Lemon + Boiling" approach substantially decreased the concentrations of halo-DBPs and the cytotoxicity of tap water.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
18356111-4	2008	A 1.0 ns molecular dynamics simulation of the CRP-cAMP-DNA complex in explicit solvent was performed, and assessed for water-mediated CRP-DNA hydrogen bonds; results were compared to several X-ray crystal structures of comparable complexes.	Water	119-124	catabolite gene activator protein	Escherichia coli	46-49
18356111-4	2008	A 1.0 ns molecular dynamics simulation of the CRP-cAMP-DNA complex in explicit solvent was performed, and assessed for water-mediated CRP-DNA hydrogen bonds; results were compared to several X-ray crystal structures of comparable complexes.	Water	119-124	catabolite gene activator protein	Escherichia coli	134-137
18356111-5	2008	While several water-mediated CRP-DNA hydrogen bonds were identified, none of these involved the T:A base pair at position 6.	Water	14-19	catabolite gene activator protein	Escherichia coli	29-32
32854008-7	2021	This strategy could be applied to control halo-DBPs, as well as to lower the adverse health effects of halo-DBPs on humans through tap water ingestion.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	131-134
32858465-4	2021	In experiment 1, chicks that received intracerebroventricular (ICV) injection of VIP had reduced food intake for up to 180 min after injection and reduced water intake for 90 min.	Water	155-160	VIP peptides	Coturnix japonica	81-84
17869387-5	2008	Co-crystal structures of inhibitors bound to Wee1 show that the pyrrolo[3,4-c]carbazole scaffold binds in the ATP-binding site, with N-6 substituents involved in H-bonding to conserved water molecules.	Water	185-190	WEE1 G2 checkpoint kinase	Homo sapiens	45-49
17509635-4	2007	As compared to the referent category (below limit of detection to 20 microg of As/L), the overall population mean systolic blood pressure rose 1.29 mm Hg (95% CI 0.82, 1.75), 1.28 mm Hg (95% CI 0.49, 2.07), and 2.22 mm Hg (95% CI 1.46, 2.97) as drinking water arsenic concentration increased from 21 to 50, 51 to 100, and &gt;100 microg of As/L, respectively.	Water	254-259	argininosuccinate lyase	Homo sapiens	79-83
17525153-1	2007	Indirect evidence suggests that the Muller/glial cell water channel aquaporin-4 (AQP4) modulates K(+) channel function of the closely associated Kir4.1 protein.	Water	54-59	aquaporin 4	Mus musculus	68-79
17525153-1	2007	Indirect evidence suggests that the Muller/glial cell water channel aquaporin-4 (AQP4) modulates K(+) channel function of the closely associated Kir4.1 protein.	Water	54-59	aquaporin 4	Mus musculus	81-85
33035875-6	2021	A kinetic approach to sorption in fresh water (pH = 8.05; 179.5 muS cm-1) at room temperature was carried out by means of the flow field flow analysis method (AF4) to determine the partition coefficients and water sampling rates between nanoplastics and cigarette butts.	Water	40-45	AF4/FMR2 family member 1	Homo sapiens	159-162
17499259-1	2007	A disk-type solid-phase extraction (SPE) method was used for the extraction of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in natural water and tap water.	Water	166-171	nuclear RNA export factor 1	Homo sapiens	162-165
33068851-3	2021	Perfluorooctanoic acid (PFOA) was found to be predominant, concentrations of which ranged from 40.4 to 845 ng/mL in serum, from 2.88 to 19.3 ng/L in tap water, from 4.40 to 189 ng/g in soil, and accounting for 84.1-98.6%, 15.9-79.8%, and 73.8-96.7% of the total PFASs, respectively.	Water	153-158	nuclear RNA export factor 1	Homo sapiens	149-152
17574218-4	2007	On the other hand, real-time RT-PCR analyses of brains of animals exposed to water-immersion restraint stress (WRS) showed that WRS significantly up-regulated GILZ expression in the medial prefrontal cortex (mPFC) and hippocampus, which are known to be mental stress-related areas, suggesting the multiple roles of GILZ in the brain.	Water	77-82	TSC22 domain family, member 3	Mus musculus	159-163
17574218-4	2007	On the other hand, real-time RT-PCR analyses of brains of animals exposed to water-immersion restraint stress (WRS) showed that WRS significantly up-regulated GILZ expression in the medial prefrontal cortex (mPFC) and hippocampus, which are known to be mental stress-related areas, suggesting the multiple roles of GILZ in the brain.	Water	77-82	TSC22 domain family, member 3	Mus musculus	315-319
18506888-1	2008	UNLABELLED: Melittin, a water-soluble toxic peptide derived from bee venom of Apis mellifera was reported to have inhibitory effects on hepatocellular carcinoma (HCC).	Water	24-29	melittin	Apis mellifera	12-20
32506554-2	2021	Aquaporin 4 (AQP4) is abundantly expressed in glia and ependymal cells of the mammalian brain and has been proposed to act as a gatekeeper for brain water dynamics, predominantly based on studies utilizing AQP4-deficient mice.	Water	149-154	aquaporin 4	Homo sapiens	0-11
18474738-2	2008	Its antigen is the astrocytic water channel aquaporin-4; NMO-IgG has not been described in a cancer context.	Water	30-35	aquaporin 4	Homo sapiens	44-55
18041061-1	2008	The water-soluble domain of rat microsomal cytochrome b(5) is a convenient protein with which to inspect the connection between amino acid sequence and thermodynamic properties.	Water	4-9	cytochrome b5 type A	Rattus norvegicus	43-57
17569093-0	2007	Adsorption-penetration studies of glucose oxidase into phospholipid monolayers at the 1,2-dichloroethane/water interface.	Water	105-110	hydroxyacid oxidase 1	Homo sapiens	34-49
17569093-1	2007	The interaction between glucose oxidase (GOx) and phospholipid monolayers is studied at the 1,2-dichloroethane/water interface by electrochemical impedance spectroscopy.	Water	111-116	hydroxyacid oxidase 1	Homo sapiens	24-39
17569093-1	2007	The interaction between glucose oxidase (GOx) and phospholipid monolayers is studied at the 1,2-dichloroethane/water interface by electrochemical impedance spectroscopy.	Water	111-116	hydroxyacid oxidase 1	Homo sapiens	41-44
17569550-1	2007	The aggregation behavior in water-rich solutions of five iron(II) complexes with alkylated derivatives of 2,2"-bipyridine was studied by electron microscopy (cryo-SEM, SEM, and TEM) and AFM.	Water	28-33	MFT2	Homo sapiens	177-180
32506554-2	2021	Aquaporin 4 (AQP4) is abundantly expressed in glia and ependymal cells of the mammalian brain and has been proposed to act as a gatekeeper for brain water dynamics, predominantly based on studies utilizing AQP4-deficient mice.	Water	149-154	aquaporin 4	Homo sapiens	13-17
33080433-8	2021	This seasonal heterogeneity is then tested for its possible impact on rationalization of water quality monitoring locations for Kali River basin in India.	Water	89-94	SLAM family member 6	Homo sapiens	128-132
17436292-8	2007	Furthermore, the behavioral sequence of eating and increased activity exhibited by DE animals in the minutes following water drinking is accompanied by a further increase in the number of Fos-ir nuclei in the LHA.	Water	119-124	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	188-191
18470314-8	2008	Consumption of tap water at home was a significant predictor of PFOA blood concentrations in Arnsberg.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
18504848-3	2008	The aim of the present study was to evaluate the indoor health risks due to tap water consumption contaminated by BTEX.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
18504848-6	2008	For evaluation of human risks due to the use of contaminated tap water, a mathematical model was elaborated.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
33183690-2	2021	Consequently, this study explored the feasibility of using low and high carbon containing alum sludge from two water treatment plants to synthesize zeolite LTA.	Water	111-116	lymphotoxin alpha	Homo sapiens	156-159
18624260-11	2008	CPAP/PEEP were used by 44% of the surveyed units, generally with initiating pressure of 5 cm H2O.	Water	93-96	centromere protein J	Homo sapiens	0-4
17555576-8	2007	However, several conserved and treatment specific responses were identified that are consistent with proliferation (Fos, Cdkn1a, Anapc1), and water imbibition (Slc30a3, Slc30a5) responses elicited by EE.	Water	142-147	solute carrier family 30 (zinc transporter), member 3	Mus musculus	160-167
17339611-10	2007	We hypothesize that the AQPs may play roles both in the water movement underlying compensatory mechanisms for changes in extracellular osmolarity and, in the case of AQP5 in particular, in the gustatory response to water.	Water	215-220	aquaporin 5	Rattus norvegicus	166-170
33047995-0	2021	Microencapsulated Soil Conditioner with a Water-Soluble Core: Improving Soil Nutrition of Crop Root.	Water	42-47	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	90-94
17767880-7	2007	The main source of water for drinking and daily life among emigrations was tap water (85.4% and 87.0%).	Water	19-24	nuclear RNA export factor 1	Homo sapiens	75-78
17767880-7	2007	The main source of water for drinking and daily life among emigrations was tap water (85.4% and 87.0%).	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
18074338-2	2008	The implicit water model uses the finite difference Poisson (FDP) model with the smooth permittivity method implemented in the OpenEye ZAP libraries.	Water	13-18	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	135-138
18492345-3	2008	This method quantifies trace levels of methyl tertiary-butyl ether, ethyl tertiary-butyl ether, di-isopropyl ether, and tertiary-amyl methyl ether in tap water.	Water	154-159	nuclear RNA export factor 1	Homo sapiens	150-153
18492345-4	2008	The method achieves detection limits of less than 0.025 microg/L for all analytes and linear ranges of three orders of magnitude in the measurement of the alkyl ether fuel oxygenates in 5-mL tap water samples.	Water	195-200	nuclear RNA export factor 1	Homo sapiens	191-194
18492345-7	2008	Methyl tertiary-butyl ether was detected in samples of tap water taken from geographically diverse regions of the United States.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
17822625-2	2007	METHODS: Mercaptoacetic acid (MAA) modified QDs were linked to mouse-anti-human alpha-fetoprotein (AFP) monoclonal antibody to form water soluble QD-AFP-Ab probes, which were validated by spectra analyses and transmission electron microscope.	Water	132-137	alpha fetoprotein	Mus musculus	80-97
17822625-2	2007	METHODS: Mercaptoacetic acid (MAA) modified QDs were linked to mouse-anti-human alpha-fetoprotein (AFP) monoclonal antibody to form water soluble QD-AFP-Ab probes, which were validated by spectra analyses and transmission electron microscope.	Water	132-137	alpha fetoprotein	Mus musculus	99-102
17822625-2	2007	METHODS: Mercaptoacetic acid (MAA) modified QDs were linked to mouse-anti-human alpha-fetoprotein (AFP) monoclonal antibody to form water soluble QD-AFP-Ab probes, which were validated by spectra analyses and transmission electron microscope.	Water	132-137	alpha fetoprotein	Mus musculus	149-152
33104816-8	2021	Whereas, tap water and effervescent tablets had 15% and 49% efficiency, respectively.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
17535441-8	2007	Using a combination of case control methodology and spatial analysis, the spatial patterns of THMs and individual measures of tap water consumption provide estimates of the effects of ingestion of specific amounts of some DBPs on rectal cancer risk.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
17942224-8	2008	The method was applied to the determination of molybdenum(VI) in steels and tap water and well water samples.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
33186537-2	2021	Most patients have serum antibodies targeting the aquaporin-4 water channel expressed on the end-feet of astrocytes.	Water	62-67	aquaporin 4	Homo sapiens	50-61
17432897-7	2007	Most anions that favor processes that expose protein surface to water (e.g., SCN-), and hence must interact favorably with (i.e., accumulate at) protein surface, are also accumulated at the air-water interface (Kp &gt;1, e.g., Kp,SCN- =1.6).	Water	64-69	sorcin	Homo sapiens	77-80
32910547-7	2021	This occurred along with a 2.1-fold increase in mRNA expression of aquaporin-4 water channels and a 7.1-fold decrease in mRNA expression of alpha-syntrophin protein, which anchors aquaporin-4 to the BBB.	Water	79-84	aquaporin 4	Mus musculus	67-78
17432897-7	2007	Most anions that favor processes that expose protein surface to water (e.g., SCN-), and hence must interact favorably with (i.e., accumulate at) protein surface, are also accumulated at the air-water interface (Kp &gt;1, e.g., Kp,SCN- =1.6).	Water	194-199	sorcin	Homo sapiens	77-80
18092361-0	2008	Water-deprivation-induced expression of neuronal nitric oxide synthase in the hypothalamic paraventricular nucleus of rat.	Water	0-5	nitric oxide synthase 1	Rattus norvegicus	40-70
18092361-5	2008	nNOS-ir neurons significantly increased with water deprivation and decreased with rehydration, both in the posterior magnocellular (pM)- and the medial parvocellular (mP)-PVN.	Water	45-50	nitric oxide synthase 1	Rattus norvegicus	0-4
18092361-9	2008	Significant amounts of NADPH-d-stained neurons in the PVN of water-deprived rats (67-68% in both the mP and the pM) exhibited c-Fos-ir.	Water	61-66	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	126-131
18092361-10	2008	NADPH-d/c-Fos neurons in the pM-PVN were increased by water deprivation but not changed by rehydration.	Water	54-59	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	8-13
17447762-5	2007	Removal of the ordered water, along with placing reinforcing mutations to favor the desired orientation of retinal, led to a triple mutant CRABPII protein capable of nanomolar binding of retinal as a protonated Schiff base.	Water	23-28	cellular retinoic acid binding protein 2	Homo sapiens	139-146
33255057-2	2021	And then the fluorescent probe was employed for detection of Fe3+ in tap water, coal gangue, fly ash and food samples successfully.	Water	73-78	l(2)FE3	Drosophila melanogaster	61-64
17613234-0	2007	The role of aquaporin-4 in cerebral water transport and edema.	Water	36-41	aquaporin 4	Mus musculus	12-23
18427121-8	2008	The qualitatively different hydration of the beta-lactoglobulin pore and carbon nanotubes is caused by subtle differences in water-wall interactions and water entropy.	Water	125-130	beta-lactoglobulin	Bos taurus	45-63
18427121-8	2008	The qualitatively different hydration of the beta-lactoglobulin pore and carbon nanotubes is caused by subtle differences in water-wall interactions and water entropy.	Water	153-158	beta-lactoglobulin	Bos taurus	45-63
17613234-3	2007	Aquaporin-4 (AQP4) is the primary cellular water channel in the brain, localized to astrocytic foot processes along the blood-brain barrier and brain-cerebrospinal fluid interface.	Water	43-48	aquaporin 4	Mus musculus	0-11
33073913-4	2021	Here, we show that upon leaf infiltration of water, BTH-primed Arabidopsis thaliana plants accumulate higher amounts of mRNA of ARGONAUTE (AGO)2 and AGO3, key components of RNA silencing.	Water	45-50	ARGONAUTE 3	Arabidopsis thaliana	149-153
17613234-3	2007	Aquaporin-4 (AQP4) is the primary cellular water channel in the brain, localized to astrocytic foot processes along the blood-brain barrier and brain-cerebrospinal fluid interface.	Water	43-48	aquaporin 4	Mus musculus	13-17
17613234-4	2007	Multiple studies of transgenic mice with a complete deficiency or altered expression of AQP4 suggest a prominent role for AQP4 in cerebral water transport.	Water	139-144	aquaporin 4	Mus musculus	88-92
17613234-4	2007	Multiple studies of transgenic mice with a complete deficiency or altered expression of AQP4 suggest a prominent role for AQP4 in cerebral water transport.	Water	139-144	aquaporin 4	Mus musculus	122-126
17613234-7	2007	The data strongly support the conclusion that AQP4 plays a pivotal role in cerebral water transport and is an essential mediator in the formation and resorption of edema fluid from the brain parenchyma.	Water	84-89	aquaporin 4	Mus musculus	46-50
18366205-4	2008	The effect of water-water interactions on the Hg2+ hydration properties has been evaluated using the SPC/E and TIP5P water models.	Water	14-19	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	46-49
18366205-4	2008	The effect of water-water interactions on the Hg2+ hydration properties has been evaluated using the SPC/E and TIP5P water models.	Water	20-25	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	46-49
18366205-4	2008	The effect of water-water interactions on the Hg2+ hydration properties has been evaluated using the SPC/E and TIP5P water models.	Water	20-25	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	46-49
33068891-1	2021	Clearance of amyloid-beta (Abeta) from the brain is hypothesized to be mediated by the glymphatic system through aquaporin-4 (AQP4) water channels.	Water	132-137	aquaporin 4	Homo sapiens	113-124
18241265-11	2008	This was associated with an increase in epidermal water content of DHCR24-/- mice.	Water	50-55	24-dehydrocholesterol reductase	Mus musculus	67-73
18241265-12	2008	CONCLUSIONS: This is the first demonstration that elevated AQP3 results in the retention of epidermal water, causing the taut, wrinkle-free skin phenotype of the DHCR24-/- mice.	Water	102-107	24-dehydrocholesterol reductase	Mus musculus	162-168
19071743-5	2007	Based on these features, the system was applied to tap-water and surface water samples with no previous treatment required.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
33068891-1	2021	Clearance of amyloid-beta (Abeta) from the brain is hypothesized to be mediated by the glymphatic system through aquaporin-4 (AQP4) water channels.	Water	132-137	aquaporin 4	Homo sapiens	126-130
17485621-0	2007	Bottled, filtered, and tap water use in Latino and non-Latino children.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
18381427-7	2008	Both reactive oxygen species generation and apoptotic cell death of Ker/ODC may, at least in part, be due to induction of a polyamine catabolic pathway that generates both H(2)O(2) and cytotoxic aldehydes, because spermine oxidase (SMO) levels are induced in Ker/ODC.	Water	172-177	ornithine decarboxylase, structural 1	Mus musculus	72-75
17485621-9	2007	Latino parents were less likely than non-Latino parents to drink tap water (odds ratio, 0.26; 95% confidence interval, 0.10-0.67) and less likely to give tap water to their children (odds ratio, 0.32; 95% confidence interval, 0.15-0.70).	Water	158-163	nuclear RNA export factor 1	Homo sapiens	154-157
33068891-2	2021	Genetic variation of AQP4 may impact water channel function, Abeta clearance, and clinical outcomes.	Water	37-42	aquaporin 4	Homo sapiens	21-25
33320637-5	2020	It was found that the water molecules interacting with one polymer oxygen atom (BW1), of which most are IW molecules, in PMC2A exhibit the lowest mobility, while those in PBA and PMC1A show a higher mobility.	Water	22-27	BW1	Homo sapiens	80-83
17485621-10	2007	More Latinos believed that tap water would make them sick (odds ratio, 5.63; 95% confidence interval, 2.17-14.54).	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
17485621-14	2007	CONCLUSIONS: Many Latino families avoid drinking tap water because they fear it causes illness.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
33141134-5	2020	The surface modification of HA provided ZrO2-x-B@SiO2-HA with water dispersibility and a targeting capability for CD44 overexpressed cancer cells.	Water	62-67	CD44 molecule (Indian blood group)	Homo sapiens	114-118
17355873-3	2007	The amount of PLA(2), which resides in a 21+/-1 A thick layer at the water-bilayer interface, as well as its depth of penetration into the membrane, increase during the lag phase, the length of which is also proportional to the enzyme concentration.	Water	69-74	phospholipase A2 group IIA	Homo sapiens	14-19
18194855-2	2008	This review focuses on AQP0 and AQP4, which in addition to forming water channels also appear to play a role in cell adhesion.	Water	67-72	aquaporin 4	Homo sapiens	32-36
33035479-7	2020	However, the role of CB1 receptors in the control of water intake is still a matter of debate [27-31].	Water	53-58	cannabinoid receptor 1	Rattus norvegicus	21-24
18572597-3	2008	K/GCNF intercalates act as radical-anion alkene polymerization catalysts and reduce water with stoichiometric formation of hydrogen gas.	Water	84-89	nuclear receptor subfamily 6 group A member 1	Homo sapiens	2-6
18184763-13	2008	ANG-(1-7) contributes to the enhanced water intake during pregnancy, allowing maintenance of the normal volume-expanded state despite diuresis produced in part by decreased AVP and AQP1.	Water	38-43	angiogenin	Rattus norvegicus	0-8
17282996-4	2007	A recently identified specific serum autoantibody biomarker, NMO-IgG, targets aquaporin-4 (AQP4), the most abundant water channel protein in the CNS, which is highly concentrated in astrocytic foot processes.	Water	116-121	aquaporin 4	Homo sapiens	78-89
17282996-4	2007	A recently identified specific serum autoantibody biomarker, NMO-IgG, targets aquaporin-4 (AQP4), the most abundant water channel protein in the CNS, which is highly concentrated in astrocytic foot processes.	Water	116-121	aquaporin 4	Homo sapiens	91-95
33035479-8	2020	Here, we show that endogenous activation of CB1 in cortical glutamatergic neurons of the ACC promotes water intake.	Water	102-107	cannabinoid receptor 1	Rattus norvegicus	44-47
17449477-1	2007	NMO-IgG is a disease-specific autoantibody for neuromyelitis optica (NMO) and its target antigen is aquaporin-4 (AQP4) water channel.	Water	119-124	aquaporin 4	Homo sapiens	100-111
17449477-1	2007	NMO-IgG is a disease-specific autoantibody for neuromyelitis optica (NMO) and its target antigen is aquaporin-4 (AQP4) water channel.	Water	119-124	aquaporin 4	Homo sapiens	113-117
18392436-4	2008	Recent studies have shown that NMO has more frequently a relapsing course, and results from attack to aquaporin-4 which is the dominant water channel in the central nervous system, located in foot processes of the astrocytes.	Water	136-141	aquaporin 4	Homo sapiens	102-113
33035479-9	2020	Notably, presynaptic CB1 receptors of ACC glutamatergic neurons are abundantly located in the basolateral amygdala (BLA), a key area in the regulation of water intake.	Water	154-159	cannabinoid receptor 1	Rattus norvegicus	21-24
33297299-1	2020	Aquaporin 4 (AQP4) is the most abundant water channel in the central nervous system (CNS).	Water	40-45	aquaporin 4	Homo sapiens	0-11
18063285-3	2008	In this study, we examined the influence of soluble organic compounds in drinking water leached from Pliocene lignite from BEN-endemic areas on plasma lecithin-cholesterol acyltransferase (LCAT) activity.	Water	82-87	lecithin-cholesterol acyltransferase	Homo sapiens	151-187
17257651-7	2007	The degradation rate of TPBP in the five test water samples was related to the simultaneous photolysis formation of phenol and Peak #1.	Water	46-51	pseudopodium enriched atypical kinase 1	Homo sapiens	127-134
18063285-3	2008	In this study, we examined the influence of soluble organic compounds in drinking water leached from Pliocene lignite from BEN-endemic areas on plasma lecithin-cholesterol acyltransferase (LCAT) activity.	Water	82-87	lecithin-cholesterol acyltransferase	Homo sapiens	189-193
33297299-1	2020	Aquaporin 4 (AQP4) is the most abundant water channel in the central nervous system (CNS).	Water	40-45	aquaporin 4	Homo sapiens	13-17
18063285-5	2008	Water samples from BEN villages from Serbia and Romania showed higher LCAT inhibiting activity (p=0.02) and (p=0.003), respectively, compared to deionised water and non-endemic water.	Water	0-5	lecithin-cholesterol acyltransferase	Homo sapiens	70-74
33161359-9	2020	System maps for XBridge Shield RP18 for 20-70% (v/v) methanol-water and Synergi Hydro-RP and 50% (v/v) methanol-water at temperatures from 25-65  C together with a correlation diagram for XBridge Shield RP18 and SunFire C18 are presented as representative applications of the reduced calibration compounds for column selectivity evaluation.	Water	62-67	pre-mRNA processing factor 3	Homo sapiens	31-35
17766192-8	2008	CONCLUSIONS: These results show for the first time in vivo pharmacological stimulation of salivary secretion by a water-soluble CFTR potentiator, MPB-07 and by the isoflavone, ethanol-soluble genistein and suggest that this chloride channel plays an important role in salivary gland physiology.	Water	114-119	cystic fibrosis transmembrane conductance regulator	Mus musculus	128-132
17502745-9	2007	CONCLUSIONS: The important message conveyed by this case was the finding that for several years, unknown to his eye care physicians, the patient cleaned his lenses with the Boston Cleaning System, as instructed, but followed this step with a routine rinse with tap water and storage in tap water in his lens case, which was not replaced or cleaned.	Water	265-270	nuclear RNA export factor 1	Homo sapiens	261-264
17502745-9	2007	CONCLUSIONS: The important message conveyed by this case was the finding that for several years, unknown to his eye care physicians, the patient cleaned his lenses with the Boston Cleaning System, as instructed, but followed this step with a routine rinse with tap water and storage in tap water in his lens case, which was not replaced or cleaned.	Water	265-270	nuclear RNA export factor 1	Homo sapiens	286-289
17502745-9	2007	CONCLUSIONS: The important message conveyed by this case was the finding that for several years, unknown to his eye care physicians, the patient cleaned his lenses with the Boston Cleaning System, as instructed, but followed this step with a routine rinse with tap water and storage in tap water in his lens case, which was not replaced or cleaned.	Water	290-295	nuclear RNA export factor 1	Homo sapiens	261-264
33161359-9	2020	System maps for XBridge Shield RP18 for 20-70% (v/v) methanol-water and Synergi Hydro-RP and 50% (v/v) methanol-water at temperatures from 25-65  C together with a correlation diagram for XBridge Shield RP18 and SunFire C18 are presented as representative applications of the reduced calibration compounds for column selectivity evaluation.	Water	112-117	pre-mRNA processing factor 3	Homo sapiens	31-35
33344852-0	2020	Actinyl-Carboxylate Complexes [AnO2(COOH) n (H2O) m ]2-n (An = U, Np, Pu, and Am; n = 1-3; m = 0, 2, 4; 2n + m = 6): Electronic Structures, Interaction Features, and the Potential to Adsorbents toward Cs Ion.	Water	45-48	anoctamin 2	Homo sapiens	31-35
17329245-7	2007	The elongation of Pen-2 N terminus caused a reduction in the water accessibility of the luminal side of the catalytic pore of PS1 in a similar manner to that caused by an Abeta42-raising gamma-secretase modulator, fenofibrate, as determined by substituted cysteine accessibility method.	Water	61-66	presenilin enhancer, gamma-secretase subunit	Homo sapiens	18-23
33344852-2	2020	Herein, detailed studies on the binding sites of [AnO2(COOH) n (H2O) m ]2-n (An = U, Np, Pu, and Am; n = 1-3; m = 0, 2, 4; 2n + m = 6) complexes toward Cs are predicted by calculation, and their electronic excitation characteristics were illustrated, providing theoretical supports for the design of Cs adsorbents.	Water	64-67	anoctamin 2	Homo sapiens	50-54
17288999-0	2007	Effects of acute heat exposure on prosencephalic c-Fos expression in normohydrated, water-deprived and salt-loaded rats.	Water	84-89	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-54
18008383-3	2008	Moreover, the spatial positions of Trp residues in His-modified PLA2 were not properly rearranged toward lipid-water interface in the presence of Ca2+.	Water	111-116	phospholipase A2 group IIA	Homo sapiens	64-68
32919261-2	2020	The aim of this work was to characterize the bacterial communities in tap water and bottled mineral water, the two predominant sources of drinking water in modern societies.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
18260012-1	2008	Two tiny hairpin DNAs, CORE (dAGGCTTCGGCCT) and AP2 (dAGGCTXCGGCCT; X: abasic nucleotide), fold into almost the same tetraloop hairpin structure with one exception, that is, the sixth thymine (T6) of CORE is exposed to the solvent water (Kawakami, J. et al., Chem.	Water	231-236	transcription factor AP-2 alpha	Homo sapiens	48-51
17328541-3	2007	a undergoes an abrupt spin crossover (SCO) at 255 K with a hysteresis loop of 6 K. a.CH3OH, 2a.H2O, and 2b.H2O exhibit irreversible SCO behaviors due to the loss of solvent molecules upon heating.	Water	95-98	spindlin 1	Homo sapiens	22-26
17328541-3	2007	a undergoes an abrupt spin crossover (SCO) at 255 K with a hysteresis loop of 6 K. a.CH3OH, 2a.H2O, and 2b.H2O exhibit irreversible SCO behaviors due to the loss of solvent molecules upon heating.	Water	107-110	spindlin 1	Homo sapiens	22-26
17328541-4	2007	3a, 3b, 4a, and 5a.H2O show simple spin transitions above 350 K. The desolvated samples of 4b.CH3OH and 5b.H2O undergo two-step spin transitions.	Water	19-22	spindlin 1	Homo sapiens	35-39
32919261-7	2020	Significant differences were observed between mineral and tap water, with a general dominance of Alphaproteobacteria (mainly the genus Blastomonas) in tap water and Gammaproteobacteria in mineral water with Acidovorax being the dominant genus in 3 out of 7 mineral water brands.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	151-154
17328541-4	2007	3a, 3b, 4a, and 5a.H2O show simple spin transitions above 350 K. The desolvated samples of 4b.CH3OH and 5b.H2O undergo two-step spin transitions.	Water	19-22	spindlin 1	Homo sapiens	128-132
17328541-4	2007	3a, 3b, 4a, and 5a.H2O show simple spin transitions above 350 K. The desolvated samples of 4b.CH3OH and 5b.H2O undergo two-step spin transitions.	Water	107-110	spindlin 1	Homo sapiens	128-132
18247594-0	2008	Assessment of multicoefficient correlation methods, second-order Moller-Plesset perturbation theory, and density functional theory for H3O(+)(H2O)n (n = 1-5) and OH(-)(H2O)n (n = 1-4).	Water	142-145	H3 clustered histone 15	Homo sapiens	135-138
32919261-7	2020	Significant differences were observed between mineral and tap water, with a general dominance of Alphaproteobacteria (mainly the genus Blastomonas) in tap water and Gammaproteobacteria in mineral water with Acidovorax being the dominant genus in 3 out of 7 mineral water brands.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	151-154
32919261-7	2020	Significant differences were observed between mineral and tap water, with a general dominance of Alphaproteobacteria (mainly the genus Blastomonas) in tap water and Gammaproteobacteria in mineral water with Acidovorax being the dominant genus in 3 out of 7 mineral water brands.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	151-154
33276663-2	2020	In CA1, as a monohydrate, the hydrogen bonds were pronounced around the water of crystallization (O4), and the planar cyclic sites were arranged in parallel to slightly tilted positions.	Water	72-77	carbonic anhydrase 1	Homo sapiens	3-6
18220387-3	2008	This enables us to capture asymmetric lipid membranes at air-water interfaces which are otherwise unattainable with a conventional SCF model.	Water	61-66	KIT ligand	Homo sapiens	131-134
19554128-0	2007	Rate of pediatric tap water scald injuries in eastern Ontario.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
19554128-1	2007	BACKGROUND: Tap water scalds can be devastating and are entirely preventable.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
19554128-4	2007	OBJECTIVES: The present study evaluated the rate of pediatric tap water scalds in Ottawa, Ontario over the 10-year period from 1993 to 2002 in an attempt to identify the impact of this national awareness campaign.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
19554128-5	2007	METHODS: Data from the Children"s Hospital of Eastern Ontario available in the Canadian Hospitals Injury Reporting and Prevention Program database were used to calculate the yearly incidence density of tap water scalds among children younger than 15 years in the city of Ottawa.	Water	206-211	nuclear RNA export factor 1	Homo sapiens	202-205
17963868-1	2008	Atrial natriuretic factor (ANF) and dopamine (DA) are both important regulators of sodium and water transport across renal proximal tubules.	Water	94-99	natriuretic peptide A	Rattus norvegicus	0-25
33068939-5	2020	The sea anemone Actinia fragacea produces a water-soluble RGD-peptide fragacea toxin C (FraC) suggesting the possible activity of FraC against PIK3CA/KRAS-mutant CRCSCs.	Water	44-49	KRAS proto-oncogene, GTPase	Homo sapiens	150-154
17963868-1	2008	Atrial natriuretic factor (ANF) and dopamine (DA) are both important regulators of sodium and water transport across renal proximal tubules.	Water	94-99	natriuretic peptide A	Rattus norvegicus	27-30
17963868-2	2008	Many evidences suggest that some of ANF inhibitory effects on sodium and water reabsorption are mediated by dopaminergic mechanisms.	Water	73-78	natriuretic peptide A	Rattus norvegicus	36-39
17208275-4	2007	A significant change of the Tri- to HpBDE congener profile (% of total BDE 28, 47, 99, 153, 154, 183 without 209) in sludge from different stages of the waste water treatment process (primary sludge, secondary excess sludge and (dewatered) digested sludge), indicating a degradation of DeBDE to these congeners, was not observed.	Water	159-164	homeobox D13	Homo sapiens	38-41
18489334-14	2007	While in the mineral water group finger circumference decreased significantly, measurements in the tap water group revealed a statistically significant increase.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
32707319-11	2020	Therefore, boiling and domestic filtering of tap water may be recommended for the removal of HALs prior to consuming tap water.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
17202139-9	2007	Based on these features, we suggest here a catalytic mechanism for hCAII: the tautomerization of His(64) can mediate the transfers of both protons and water molecules at a neutral pH with high efficiency, requiring no time- or energy-consuming processes.	Water	151-156	carbonic anhydrase 2	Homo sapiens	67-72
32707319-11	2020	Therefore, boiling and domestic filtering of tap water may be recommended for the removal of HALs prior to consuming tap water.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	117-120
17984171-5	2008	Network analyses suggested that upregulated expression of chromosome 21 genes such as S100B and amyloid precursor protein activated the stress response kinase pathways, and furthermore, could be linked to upregulation of the water channel aquaporin 4 (AQP4).	Water	225-230	aquaporin 4	Homo sapiens	239-250
17388294-2	2007	At first, the energy-rich H+(H2O)2 was reproduced by simulating a collision reaction between the protonated water monomer H3O+ and H2O.	Water	108-113	H3 clustered histone 15	Homo sapiens	122-125
17984171-5	2008	Network analyses suggested that upregulated expression of chromosome 21 genes such as S100B and amyloid precursor protein activated the stress response kinase pathways, and furthermore, could be linked to upregulation of the water channel aquaporin 4 (AQP4).	Water	225-230	aquaporin 4	Homo sapiens	252-256
17388294-2	2007	At first, the energy-rich H+(H2O)2 was reproduced by simulating a collision reaction between the protonated water monomer H3O+ and H2O.	Water	29-32	H3 clustered histone 15	Homo sapiens	122-125
32707319-11	2020	Therefore, boiling and domestic filtering of tap water may be recommended for the removal of HALs prior to consuming tap water.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	45-48
32707319-11	2020	Therefore, boiling and domestic filtering of tap water may be recommended for the removal of HALs prior to consuming tap water.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
32717516-8	2020	The promoting role of plasma could be mainly ascribed to the enhanced strength of oxygen mobility and plasma-assisted decomposition of surface carbonate in the presence of water, as revealed by the in-situ NTP-TPR, XPS, and the ex-situ DRIFTS analyses.	Water	172-177	translocated promoter region, nuclear basket protein	Homo sapiens	210-213
18713446-5	2008	Water stress also induced increases in the activities of the chloroplastic and cytosolic anti-oxidant enzymes superoxide dismutase (SOD), ascorbate peroxidase (APX), and glutathione reductase (GR), and the increases in the activities of anti-oxidant enzymes were reduced by pretreatments with inhibitors of NOS and NR.	Water	0-5	APx1-Cytosolic Ascorbate Peroxidase	Zea mays	138-158
18713446-5	2008	Water stress also induced increases in the activities of the chloroplastic and cytosolic anti-oxidant enzymes superoxide dismutase (SOD), ascorbate peroxidase (APX), and glutathione reductase (GR), and the increases in the activities of anti-oxidant enzymes were reduced by pretreatments with inhibitors of NOS and NR.	Water	0-5	APx1-Cytosolic Ascorbate Peroxidase	Zea mays	160-163
17315931-2	2007	This water-stable chiral Lewis acid promotes condensation of aromatic silyl enol ethers with a range of aldehydes with good yields, excellent syn-diastereoselectivity and up to 92% ee.	Water	5-10	synemin	Homo sapiens	142-145
32790044-1	2020	BACKGROUND: Specific highly polarized aquaporin-4 (AQP4) expression is reported to play a crucial role in blood-brain barrier (BBB) integrity and brain water transport balance.	Water	152-157	aquaporin 4	Mus musculus	38-49
18254034-16	2008	For chronic wounds, the relative risk of developing an infection when cleansed with tap water compared with normal saline was 0.16, (95% CI 0.01 to 2.96).	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
32790044-1	2020	BACKGROUND: Specific highly polarized aquaporin-4 (AQP4) expression is reported to play a crucial role in blood-brain barrier (BBB) integrity and brain water transport balance.	Water	152-157	aquaporin 4	Mus musculus	51-55
18254034-17	2008	Tap water was more effective than saline in reducing the infection rate in adults with acute wounds (RR 0.63, 95% CI 0.40 to 0.99).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
16953219-4	2007	Administration of 2 mg/ml doxycycline in the animals" water supply beginning at 21 days of age resulted in elevated levels of IGF-IR in mammary epithelial cells as detected by Western blotting and immunohistochemistry.	Water	54-59	insulin like growth factor 1 receptor	Homo sapiens	126-132
32652562-2	2020	However, the role for Th17/Th1 (CD4+ T cells co-expressing IFNgamma and IL-17A) cells in EAU is not yet understood.	Water	89-92	CD4 antigen	Mus musculus	32-35
17274660-1	2007	The Pd(OCOCF3)2/[(HOCH2CH2NHCOCH2)2NCH2]2-catalyzed oxidation of o-allylphenol with H2O2 in water/methanol affords a syn and anti mixture of 2-(1,2-dihydroxypropyl)phenol and 2-(2-hydroxy-1-methoxypropyl)phenol.	Water	92-97	synemin	Homo sapiens	117-120
18399208-1	2008	Spontaneously resolvable conglomerate crystals are obtained by combining racemic (rac)-1,1"-binaphthyl-2,2"-dicarboxylic acid and rac-1,2-diphenylethylenediamine, and this spontaneous resolution system is induced by water which is present in the crystallization solvent.	Water	216-221	Rac family small GTPase 1	Homo sapiens	130-135
32652562-3	2020	Using interphotoreceptor retinoid-binding protein (IRBP) peptide-induced EAU in mice, we found increased levels of Th17/Th1 cells in EAU retinae (mean 9.6 +- 4.2%) and in dLNs (mean 8.4 +- 3.9%; P = 0.01) relative to controls.	Water	73-76	retinol binding protein 3, interstitial	Mus musculus	6-49
17205268-7	2007	The Hg2+ contamination of controls in the HCl extraction method showed a nonlinear correlation with the humic acid content of sediment pore water.	Water	140-145	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	4-7
17977519-7	2008	Furthermore, the addition of NAC that replenish intracellular GSH levels inhibited generation of H(2)O(2) and apoptosis in Th1 clones.	Water	97-102	X-linked Kx blood group	Homo sapiens	29-32
32652562-3	2020	Using interphotoreceptor retinoid-binding protein (IRBP) peptide-induced EAU in mice, we found increased levels of Th17/Th1 cells in EAU retinae (mean 9.6 +- 4.2%) and in dLNs (mean 8.4 +- 3.9%; P = 0.01) relative to controls.	Water	73-76	retinol binding protein 3, interstitial	Mus musculus	51-55
17977519-8	2008	These results suggest that TBT selectively induces apoptosis via generation of H(2)O(2) in Th1 cells because of their low GSH levels, which may contribute to the Th2 predominance induced by TBT.	Water	79-84	negative elongation factor complex member C/D	Homo sapiens	91-94
33220676-1	2020	The water-soluble polysaccharide, SF-2, obtained from starfish (Asterias rollestoni), belongs to the group of polysaccharides known as mannoglucan sulfate.	Water	4-9	serine and arginine-rich splicing factor 1	Mus musculus	34-38
17963777-4	2008	Moreover, methemoglobin and GDA/n-C5H11OH/H2O assemblies can affect their structures and properties and the change in behavior is dependent on the content of methemoglobin and the composition and structure of the GDA/n-C5H11OH/H2O system.	Water	42-45	guanine deaminase	Homo sapiens	28-31
17963777-4	2008	Moreover, methemoglobin and GDA/n-C5H11OH/H2O assemblies can affect their structures and properties and the change in behavior is dependent on the content of methemoglobin and the composition and structure of the GDA/n-C5H11OH/H2O system.	Water	42-45	hemoglobin subunit gamma 2	Homo sapiens	158-171
17963777-4	2008	Moreover, methemoglobin and GDA/n-C5H11OH/H2O assemblies can affect their structures and properties and the change in behavior is dependent on the content of methemoglobin and the composition and structure of the GDA/n-C5H11OH/H2O system.	Water	42-45	guanine deaminase	Homo sapiens	213-216
17963777-4	2008	Moreover, methemoglobin and GDA/n-C5H11OH/H2O assemblies can affect their structures and properties and the change in behavior is dependent on the content of methemoglobin and the composition and structure of the GDA/n-C5H11OH/H2O system.	Water	227-230	hemoglobin subunit gamma 2	Homo sapiens	10-23
17963777-4	2008	Moreover, methemoglobin and GDA/n-C5H11OH/H2O assemblies can affect their structures and properties and the change in behavior is dependent on the content of methemoglobin and the composition and structure of the GDA/n-C5H11OH/H2O system.	Water	227-230	guanine deaminase	Homo sapiens	28-31
17963777-4	2008	Moreover, methemoglobin and GDA/n-C5H11OH/H2O assemblies can affect their structures and properties and the change in behavior is dependent on the content of methemoglobin and the composition and structure of the GDA/n-C5H11OH/H2O system.	Water	227-230	hemoglobin subunit gamma 2	Homo sapiens	158-171
17178220-1	2007	Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay.	Water	117-122	aquaporin 4	Homo sapiens	99-103
33328368-3	2020	The goal of this project was to assess the cost-benefit of POU water treatment at the tap in terms of protection from microbes in drinking water.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	86-89
17963777-4	2008	Moreover, methemoglobin and GDA/n-C5H11OH/H2O assemblies can affect their structures and properties and the change in behavior is dependent on the content of methemoglobin and the composition and structure of the GDA/n-C5H11OH/H2O system.	Water	227-230	guanine deaminase	Homo sapiens	213-216
17963777-5	2008	The relationship among the changes in the structure and properties of GDA/n-C5H11OH/H2O assemblies, the content of methemoglobin, and the composition and structure of GDA/n-C5H11OH/H2O assemblies may provide some important theoretical information for elucidation of the interaction between methemoglobin and blood cell membrane and may also be helpful for the cure of some blood diseases.	Water	84-87	guanine deaminase	Homo sapiens	167-170
17963777-5	2008	The relationship among the changes in the structure and properties of GDA/n-C5H11OH/H2O assemblies, the content of methemoglobin, and the composition and structure of GDA/n-C5H11OH/H2O assemblies may provide some important theoretical information for elucidation of the interaction between methemoglobin and blood cell membrane and may also be helpful for the cure of some blood diseases.	Water	84-87	hemoglobin subunit gamma 2	Homo sapiens	290-303
33328368-3	2020	The goal of this project was to assess the cost-benefit of POU water treatment at the tap in terms of protection from microbes in drinking water.	Water	139-144	nuclear RNA export factor 1	Homo sapiens	86-89
17963777-5	2008	The relationship among the changes in the structure and properties of GDA/n-C5H11OH/H2O assemblies, the content of methemoglobin, and the composition and structure of GDA/n-C5H11OH/H2O assemblies may provide some important theoretical information for elucidation of the interaction between methemoglobin and blood cell membrane and may also be helpful for the cure of some blood diseases.	Water	181-184	guanine deaminase	Homo sapiens	70-73
17963777-5	2008	The relationship among the changes in the structure and properties of GDA/n-C5H11OH/H2O assemblies, the content of methemoglobin, and the composition and structure of GDA/n-C5H11OH/H2O assemblies may provide some important theoretical information for elucidation of the interaction between methemoglobin and blood cell membrane and may also be helpful for the cure of some blood diseases.	Water	181-184	hemoglobin subunit gamma 2	Homo sapiens	290-303
33503649-6	2020	Miki defines the Korean Peninsula as an important place in East Asian medicine, based on the understanding that medicine does not spread from one center to other places, but moves and mixes with other systems of medicine like water flows and creates new things through it.	Water	226-231	HEPACAM family member 2	Homo sapiens	0-4
18398853-3	2008	The water-soluble domain of rat microsomal cytochrome b5 is a small globular hemoprotein.	Water	4-9	cytochrome b5 type A	Rattus norvegicus	43-56
18398854-3	2008	In the absence of heme cofactor, the water-soluble domain of rat microsomal cytochrome b5 (cyt b5) contains a long flexible region within its 42-residue heme-binding loop.	Water	37-42	cytochrome b5 type A	Rattus norvegicus	76-89
18398854-3	2008	In the absence of heme cofactor, the water-soluble domain of rat microsomal cytochrome b5 (cyt b5) contains a long flexible region within its 42-residue heme-binding loop.	Water	37-42	cytochrome b5 type A	Rattus norvegicus	91-97
32747443-3	2020	H2O2 is reduced to H2O by electrons supplied by NADPH.	Water	0-3	2,4-dienoyl-CoA reductase 1	Homo sapiens	48-53
18846597-0	2008	Efficient catalytic decomposition of formic acid for the selective generation of H2 and H/D exchange with a water-soluble rhodium complex in aqueous solution.	Water	108-113	relaxin 2	Homo sapiens	81-89
32747443-7	2020	Here we show during both non-ADP and low-ADP stimulated respiration that accelerating flux through beta-oxidation generates a corresponding increase in mitochondrial JH2O2 production, that the majority (~70-80%) of H2O2 produced is reduced to H2O by electrons drawn from redox buffering circuits supplied by NADPH, and that the rate of electron flux through redox buffering circuits is directly linked to changes in oxygen consumption mediated by NNT.	Water	167-170	2,4-dienoyl-CoA reductase 1	Homo sapiens	308-313
18595407-3	2008	It implied that the concentration of THMs in swimming pool water was higher than those in tap water, particularly, brominated-THMs.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
18595407-8	2008	Cancer risk of THMs concluded from various routes in descending order was: skin exposure while swimming, gastro-intestinal exposure from tap water intake, and skin exposure to tap water and gastro-intestinal exposure while swimming.	Water	180-185	nuclear RNA export factor 1	Homo sapiens	176-179
33179489-7	2020	The use of a simple, commercially available ligand, PAd3, is key to this water-assisted mechanism by promoting coordinative unsaturation in catalytic intermediates responsible for the heterolytic activation of strong element-hydrogen bonds, which enables broad compatibility of carbon-heteroatom cross-coupling reactions with sensitive substrates and functionality.	Water	73-78	peptidyl arginine deiminase 3	Homo sapiens	52-56
17293002-10	2008	The unique cell-specificity of the INCW protein to both proximal and distal ends of placental sac shown here for the first time is likely to greatly increase uptakes of both hexose sugars and water through turgor sensing into developing seed.	Water	192-197	miniature seed 1	Zea mays	35-39
32731063-1	2020	Community-based reverse osmosis (RO) water treatment plants are employed as an interim solution for producing safe drinking water for the endemic areas of Chronic Kidney Disease of Unknown Etiology (CKDu) in the rural dry zone of Sri Lanka.	Water	37-42	sorcin	Homo sapiens	230-233
18761636-7	2008	The ectopic expression of AtPIP2s in lily pollen increased the water permeability of the plasma membrane in pollen grains, but not in pollen tubes.	Water	63-68	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	26-32
18655912-1	2008	Of the several aquaporin (AQP) water channels expressed in the central nervous system, AQP4 is an attractive target for drug discovery.	Water	31-36	aquaporin 4	Mus musculus	87-91
18655912-3	2008	Phenotype analysis of AQP4 knockout mice indicates the involvement of AQP4 in three distinct processes: brain water balance, astroglial cell migration and neural signal transduction.	Water	110-115	aquaporin 4	Mus musculus	22-26
18655912-3	2008	Phenotype analysis of AQP4 knockout mice indicates the involvement of AQP4 in three distinct processes: brain water balance, astroglial cell migration and neural signal transduction.	Water	110-115	aquaporin 4	Mus musculus	70-74
18655912-4	2008	By slowing water uptake into the brain, AQP4 knockout mice manifest reduced brain swelling and improved outcome in models of cytotoxic cerebral oedema such as water intoxication, focal ischaemia and meningitis.	Water	11-16	aquaporin 4	Mus musculus	40-44
18655912-5	2008	However, by slowing the clearance of excess water from brain, AQP4 knockout mice do worse in models of vasogenic oedema such as brain tumour, abscess and hydrocephalus.	Water	44-49	aquaporin 4	Mus musculus	62-66
18041847-1	2007	The reaction of alkyl-substituted sec-ethoxyalkynyl acetates with water catalyzed by Hg(OTf)2 afforded alpha,beta-unsaturated esters in excellent yield with high catalytic turnover up to 1000 times under very mild reaction conditions with virtually complete E-selectivity, superior even to that of the HWE reaction.	Water	66-71	POU class 2 homeobox 2	Homo sapiens	88-93
17994721-0	2007	Effect of the air-water interface on the stability of beta-lactoglobulin.	Water	18-23	beta-lactoglobulin	Bos taurus	54-72
17901165-12	2007	H(2)O(2) generated by NADPH oxidase participates in a signal transduction pathway that maintains the GB tonic contraction by activating PAF, p38, and cPLA(2) to generate prostaglandins.	Water	0-5	phospholipase A2 group IVA	Homo sapiens	150-156
18059526-1	2007	Water channels AQP7 and AQP8 may be involved in transcellular water movement in the small intestine.	Water	0-5	aquaporin 7	Rattus norvegicus	15-19
18059526-1	2007	Water channels AQP7 and AQP8 may be involved in transcellular water movement in the small intestine.	Water	62-67	aquaporin 7	Rattus norvegicus	15-19
18059526-8	2007	Our results indicate that AQP7 and AQP8 may play a role in water movement via the apical domain of small intestine epithelial cells.	Water	59-64	aquaporin 7	Rattus norvegicus	26-30
17889847-7	2007	From experiment (1), cell osmotically inactive volume (V(b)) and the permeability coefficient of water (L(p)) for RBL cells are determined to be 41% [n=18, correlation coefficient (r(2)) of 0.903] of original/isotonic volume, and 0.32+/-0.05 microm/min/atm (n=8, r(2)&gt;0.963), respectively, for room temperature (22 degrees C).	Water	97-102	ATM serine/threonine kinase	Rattus norvegicus	253-256
17889847-8	2007	From experiment (2), the permeability coefficient of water (L(p)) and of Me(2)SO (P(s)) for RBL cells are 0.38+/-0.09 microm/min/atm and (0.49+/-0.13) x 10(-3)cm/min (n=5, r(2)&gt;0.86), respectively.	Water	53-58	ATM serine/threonine kinase	Rattus norvegicus	129-132
18027194-0	2007	Assessment and management of tap water lead contamination in Lower Saxony, Germany.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
18027194-12	2007	There were remarkable regional differences in the frequency of tap water contamination.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
18278404-8	2007	The relationship between the concentration of fluoride in tap water and the prevalence of dental caries showed a negative correlation with the coefficient of 0.81 (except 1.14 mg/L fluoride ).	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
18278404-9	2007	There was also a positive correlation between the concentration of fluoride in tap water and the community dental fluorosis index (CFI) with a coefficient of 0.78.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
17958423-8	2007	A CH2Cl2 solution under 0.30 atm of H2 and 0.13 atm of O2 converted to H2O in the presence of 1 and 10 mol % of H(OEt2)2BAr(F)4 (BAr(F)4- = B(C6H3-3,5-(CF3)2)4-).	Water	71-74	relaxin 2	Homo sapiens	36-44
17704152-1	2007	By performing homology modeling, molecular docking, and molecular dynamics simulations, we have developed three-dimensional (3D) structural models of both dopamine transporter and dopamine transporter-dopamine complex in the environment of lipid bilayer and solvent water.	Water	266-271	solute carrier family 6 member 3	Homo sapiens	155-175
17704152-1	2007	By performing homology modeling, molecular docking, and molecular dynamics simulations, we have developed three-dimensional (3D) structural models of both dopamine transporter and dopamine transporter-dopamine complex in the environment of lipid bilayer and solvent water.	Water	266-271	solute carrier family 6 member 3	Homo sapiens	180-200
17699554-1	2007	The canonical transient receptor potential channels TRPC3 and TRPC6 are abundantly expressed along with the water channel aquaporin-2 (AQP2) in principal cells of the cortical and medullary collecting duct.	Water	108-113	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	62-67
17850951-0	2007	Adsorption kinetics of c-Fos and c-Jun to air-water interfaces.	Water	46-51	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	23-28
17850951-0	2007	Adsorption kinetics of c-Fos and c-Jun to air-water interfaces.	Water	46-51	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	33-38
17850951-1	2007	The kinetics of adsorption to air-water interfaces of the biomembrane active transcription factors c-Fos, c-Jun and their mixtures is investigated.	Water	34-39	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-104
17850951-1	2007	The kinetics of adsorption to air-water interfaces of the biomembrane active transcription factors c-Fos, c-Jun and their mixtures is investigated.	Water	34-39	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-111
17521815-13	2007	When tap water was used at 12-18 degrees C (group 2) it was demonstrated clinically and histologically that the cooled wounds had less necrosis than the uncooled wounds and thus healed faster.	Water	9-14	putative ABC-transporter	Sus scrofa	5-8
17521815-15	2007	CONCLUSION: First aid cooling of a burn wound with tap water is an effective method of minimising the damage sustained during a burn, and is universally and immediately available.	Water	55-60	putative ABC-transporter	Sus scrofa	51-54
17954829-15	2007	Pulmonary water content was significantly higher in Gp2 and Gp3 than in Gp1.	Water	10-15	glycoprotein 2	Canis lupus familiaris	52-55
18007978-0	2007	Drink a toast to tap water: study suggests water consumption benefit outweighs THM hazard.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
18007978-0	2007	Drink a toast to tap water: study suggests water consumption benefit outweighs THM hazard.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	17-20
18007986-3	2007	A pooled analysis based on six case-control studies observed a positive association between tap water and bladder cancer but none for nontap fluid intake, suggesting that contaminants in tap water may be responsible for the excess risk.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
18007986-3	2007	A pooled analysis based on six case-control studies observed a positive association between tap water and bladder cancer but none for nontap fluid intake, suggesting that contaminants in tap water may be responsible for the excess risk.	Water	191-196	nuclear RNA export factor 1	Homo sapiens	92-95
17925648-0	2007	The impact of a legislative intervention to reduce tap water scald burns in an urban community.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
17925648-6	2007	Tap water scalds increased from 15 to 22 per million/yr after legislation enactment.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
17925648-11	2007	In New York City, tap water scald burns remain a significant public health risk and continue to occur within buildings exempt from current law.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
17551841-10	2007	The study found that most people (91%) in the Langas slum used wells as the main source of domestic water, whereas the rest used tap water.	Water	133-138	nuclear RNA export factor 1	Homo sapiens	129-132
17911027-2	2007	Here we show that natural Somatostatin-14 spontaneously self-assembles in water and in 150 mM NaCl into liquid crystalline nanofibrils, which follow characteristic structural features of amyloid fibrils.	Water	74-79	somatostatin	Homo sapiens	26-41
18257309-5	2007	The relative standard deviations (RSDs) and relative recoveries (n = 5) from tap water fortified samples were 3.1% -7.9%, and 101% - 105%, and from waste water fortified samples were 3.3% - 7.9%, and 92.5% - 97.0%, respectively.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
17910422-1	2007	The spectral properties of protonated water clusters, especially the difference between Eigen (H3O+) and Zundel (H5O2+) conformers and the difference between their unhydrated and dominant hydrated forms are investigated with the first principles molecular dynamics simulations as well as with the high level ab initio calculations.	Water	38-43	H3 clustered histone 15	Homo sapiens	95-98
17910422-2	2007	The vibrational modes of the excess proton in H3O+ are sensitive to the hydration, while those in H5O2+ are sensitive to the messenger atom such as Ar (which was assumed to be weakly bound to the water cluster during acquisitions of experimental spectra).	Water	196-201	H3 clustered histone 15	Homo sapiens	46-49
17910422-4	2007	This feature corresponds to the hydrating water interacting with H3O+, so it cannot appear in the Eigen core.	Water	42-47	H3 clustered histone 15	Homo sapiens	65-68
17911600-5	2007	Vaccinated mice were highly protected from EAU induced by immunization with IRBP for at least 10 wk after vaccination.	Water	43-46	retinol binding protein 3, interstitial	Mus musculus	76-80
17406836-4	2007	The water load test was performed by having subjects drinking room-temperature tap water at a predetermined rate of 15 ml/min.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	79-82
17406836-4	2007	The water load test was performed by having subjects drinking room-temperature tap water at a predetermined rate of 15 ml/min.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
17969688-6	2007	Roughly 0.1 mg/L (as Cl2) NCl3, 0.01 mg/L CNCHCl2, and 0.01 mg/L CH3NCl2 were also observed in actual swimming pool water samples.	Water	116-121	endogenous retrovirus group W member 5	Homo sapiens	21-24
17969688-6	2007	Roughly 0.1 mg/L (as Cl2) NCl3, 0.01 mg/L CNCHCl2, and 0.01 mg/L CH3NCl2 were also observed in actual swimming pool water samples.	Water	116-121	calpain 5	Homo sapiens	26-30
17985617-11	2007	The OD of the three samples receiving the same radiation dose did not present any significant difference, thus proving that laminated EDR2 film can also be used in water.	Water	164-169	polyhomeotic homolog 2	Homo sapiens	134-138
17922773-4	2007	In the cipk23 mutant, reduced transpirational water loss from leaves coincides with enhanced ABA sensitivity of guard cells during opening as well as closing reactions, without noticeable alterations in ABA content in the plant.	Water	46-51	CBL-interacting protein kinase 23	Arabidopsis thaliana	7-13
18050065-6	2007	Colored tap water pumped on the right was emptied from the left.	Water	12-17	nuclear RNA export factor 1	Homo sapiens	8-11
17915825-9	2007	Addition of PCL significantly decreased percentage water uptake and bioadhesion force compared with pure CH film.	Water	51-56	PHD finger protein 1	Homo sapiens	12-15
17762522-0	2007	Bidirectional changes in water-maze learning following recombinant adenovirus-associated viral vector (rAAV)-mediated brain-derived neurotrophic factor expression in the rat hippocampus.	Water	25-30	brain-derived neurotrophic factor	Rattus norvegicus	118-151
17334887-1	2007	The new German Drinking Water Ordinance (TrinkwV 2001) demands that the requirements of water intended for human consumption be met up to the intrinsic tap, at which the water is used.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	152-155
17334887-1	2007	The new German Drinking Water Ordinance (TrinkwV 2001) demands that the requirements of water intended for human consumption be met up to the intrinsic tap, at which the water is used.	Water	170-175	nuclear RNA export factor 1	Homo sapiens	152-155
17334889-2	2007	These regulations have to ensure that legal requirements on drinking water are met at the tap.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	90-93
17432377-0	2007	Floc size distributions in dissolved air flotation of Winnipeg tap water.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
17432377-1	2007	A bench-scale continuous flow dissolved air flotation (DAF) system was operated using Winnipeg tap water.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
17432377-5	2007	At this dosage, the DAF effluent achieved a turbidity of 0.25 NTU and color of 3.8 TCU, significantly lower than that for the tap water.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
17291108-4	2007	Rietveld structure refinements of both D-CST and (Cs, D)-CST suggest the transition, and ultimately the selectivity, is driven by changes in the positions of water molecules, in response to the initial introduction of Cs+.	Water	158-163	cystatin 12, pseudogene	Homo sapiens	41-44
17291108-4	2007	Rietveld structure refinements of both D-CST and (Cs, D)-CST suggest the transition, and ultimately the selectivity, is driven by changes in the positions of water molecules, in response to the initial introduction of Cs+.	Water	158-163	cystatin 12, pseudogene	Homo sapiens	57-60
17291108-5	2007	The changes in water position appear to disrupt the D-O-O-D dihedral associated with the CST framework in space group P42/mbc which ultimately leads to the structural transition.	Water	15-20	cystatin 12, pseudogene	Homo sapiens	89-92
17291108-6	2007	The new geometric arrangement of the water-deuteroxyl network in (Cs, D)-CST suggests that Dwater-Ddeuteroxyl repulsion forced by Cs+ exchange drives the structural transformation.	Water	37-42	cystatin 12, pseudogene	Homo sapiens	73-76
19071348-6	2007	The method was applied to the determination of uranium(VI) in tap water, waste-water and well water samples.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
17196551-7	2007	These findings reveal for the first time that AQP4 regulates not only water and ion homeostasis but also the functions of ovarian hormone and neurotransmitter.	Water	70-75	aquaporin 4	Mus musculus	46-50
17157870-4	2007	These structures reveal that, in contrast to the free protein, Y35G BPTI adopts a conformation nearly identical with that of the wild-type protein, with a water-filled cavity in place of the missing Tyr side-chain.	Water	155-160	spleen trypsin inhibitor I	Bos taurus	68-72
17257042-6	2007	On the contrary, K2(suc) and K2(dmmal) yielded preferentially the dinuclear species [fac-Ru(DMSO-S)3(H2O)(mu-dicarb)]2 (dicarb = dmmal, 11; suc, 13), with two bridging dicarboxylate moieties.	Water	101-104	RBPJ pseudogene 3	Homo sapiens	17-24
16986127-2	2007	Hemoglobin has iron in the reduced valance Fe(II) and methemoglobin has iron in the oxidized valance Fe (III), with a free energy capable of producing water from oxygen.	Water	151-156	hemoglobin subunit gamma 2	Homo sapiens	54-67
16741709-3	2007	Here, we show that early LPS-activated bone marrow derived DC (early DC, eDC), when administered subcutaneously to mice in vivo, promote tolerance to EAU induced via immunisation with interphotoreceptor retinol binding protein (IRBP) peptide 161-180.	Water	150-153	retinol binding protein 3, interstitial	Mus musculus	184-226
17157403-10	2007	It was also found that the extended operational lifetime of CPO with in situ generation of H(2)O(2) by GOx was a result that combines the stabilizing effect of glucose and lowered concentration of H(2)O(2).	Water	91-96	hydroxyacid oxidase 1	Homo sapiens	103-106
17157403-10	2007	It was also found that the extended operational lifetime of CPO with in situ generation of H(2)O(2) by GOx was a result that combines the stabilizing effect of glucose and lowered concentration of H(2)O(2).	Water	197-202	hydroxyacid oxidase 1	Homo sapiens	103-106
17386527-9	2007	Application to the analysis in pesticide spiked samples of tap water and fruit yields satisfactory apparent recoveries (84-114%), and for the extraction procedure in fruits and a commercial formulation, recoveries were of 81-98% and 104%, respectively.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
17212502-9	2007	The results provide a description, at the molecular level, for the electronic properties of water aggregates that is consistent with the current picture for the band gap of bulk water [J. V. Coe, Int.	Water	92-97	inturned planar cell polarity protein	Homo sapiens	196-199
17212502-9	2007	The results provide a description, at the molecular level, for the electronic properties of water aggregates that is consistent with the current picture for the band gap of bulk water [J. V. Coe, Int.	Water	178-183	inturned planar cell polarity protein	Homo sapiens	196-199
17206798-1	2007	Previous studies have revealed the propensity of elastin-based biopolymers to form amyloid-like fibers when dissolved in water.	Water	121-126	elastin	Homo sapiens	49-56
16943228-7	2007	CONCLUSION: These findings show that natural CD4+CD25+ regulatory T cells possess the ability to inhibit activation of IRBP-reactive T cells that have been already sensitised in vivo, and adoptive transfer of these cells ameliorates EAU even in the effector phase.	Water	233-236	CD4 antigen	Mus musculus	45-48
16943228-7	2007	CONCLUSION: These findings show that natural CD4+CD25+ regulatory T cells possess the ability to inhibit activation of IRBP-reactive T cells that have been already sensitised in vivo, and adoptive transfer of these cells ameliorates EAU even in the effector phase.	Water	233-236	retinol binding protein 3, interstitial	Mus musculus	119-123
17284903-3	2007	Since aquaporin-4 (AQP4) is a water channel with an enormous water flux capacity, we investigated in this study whether this water channel protein might play a role in myocyte swelling following myocardial infarction.	Water	61-66	aquaporin 4	Mus musculus	6-17
17284903-3	2007	Since aquaporin-4 (AQP4) is a water channel with an enormous water flux capacity, we investigated in this study whether this water channel protein might play a role in myocyte swelling following myocardial infarction.	Water	61-66	aquaporin 4	Mus musculus	19-23
17214679-1	2007	BACKGROUND: Palmar hyperhidrosis is characterized by excessive sweating on the palm, and among the various treatment modalities, tap water iontophoresis has been widely used.	Water	133-138	nuclear RNA export factor 1	Homo sapiens	129-132
17618977-6	2007	These studies indicate that AQP4 plays significant role in the development of cytotoxic edema and the absorption of excess brain water resulting from vasogenic edema.	Water	129-134	aquaporin 4	Homo sapiens	28-32
17627600-2	2007	In this context, it is surprising that even a short tripeptide like AFA samples folded/ordered conformation as demonstrated recently by NMR experiments of the peptide in aqueous solution at 280 K. In this paper, we present molecular dynamics simulation of the peptide in explicit water using OPLS-AA/L all-atom force field.	Water	280-285	AFA	Homo sapiens	68-71
17645933-5	2007	However, it is becoming increasingly appreciated that elevated prostaglandin synthesis from fever/heat activation of cyclooxygenases (COXs) in the BCSFB promotes water and ion transfer from plasma to the ventricles; this harmful fluid movement into the CSF-brain interior can be attenuated by agents that inhibit the COXs.	Water	162-167	colony stimulating factor 2	Rattus norvegicus	148-151
17366900-6	2007	Compared with the coefficient value in tap water, that in synthetic wastewater and industrial wastewater is decreased by 39.0% and 50.9%, respectively.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
16455284-3	2007	Below are presented results of investigations into the influence of temperature, gas content and the solution level in an ultrasonic cleaner on cavitation intensity in the tap water.	Water	176-181	nuclear RNA export factor 1	Homo sapiens	172-175
16455284-5	2007	It has now been found that the tap water reaches the highest cavitation intensity at temperatures below 20 degrees C but during heating at higher temperatures (20-40 degrees C) a second peak of cavitation intensity may appear-depending on the height of water in the bath and air content.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
16455284-5	2007	It has now been found that the tap water reaches the highest cavitation intensity at temperatures below 20 degrees C but during heating at higher temperatures (20-40 degrees C) a second peak of cavitation intensity may appear-depending on the height of water in the bath and air content.	Water	253-258	nuclear RNA export factor 1	Homo sapiens	31-34
17168585-3	2006	The cross-coupling reaction can generally be effected using 2 mol % of PdCl2 and 6 mol % of PPh3 as a catalyst system in THF/H2O with Cs2CO3 as a base.	Water	125-128	phosducin like 2	Homo sapiens	71-82
16901987-0	2006	A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands.	Water	121-126	aquaporin 5	Rattus norvegicus	48-59
16901987-9	2006	This mutation may have resulted in an abnormal membrane insertion or ineffective trafficking of AQP5, since the rats having this mutation showed extremely low membrane expression of AQP5 in the SMG acinar cells and decreased water secretion from their salivary glands.	Water	225-230	aquaporin 5	Rattus norvegicus	96-100
17116243-7	2006	The WT and V30M TTR mutant (valine 30 substituted with methionine) were allowed to react over a time range of 10 min to 12 h with hydroxy radical and other reactive oxygen species.	Water	130-145	transthyretin	Homo sapiens	16-19
17011626-8	2006	In contrast, stationary-phase (7-day) ccp1Delta-ccp1(W191F) exhibited wild-type tolerance to H(2)O(2), which exceeded that of ccp1Delta.	Water	93-98	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	38-42
17176821-5	2006	The average daily consumption of tap water as plain drinking water and as heated tap water, e.g. in coffee and tea, was 0.86 +/- 0.48 l and 0.94 +/- 0.69 l, respectively.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
17176821-5	2006	The average daily consumption of tap water as plain drinking water and as heated tap water, e.g. in coffee and tea, was 0.86 +/- 0.48 l and 0.94 +/- 0.69 l, respectively.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	81-84
17176821-5	2006	The average daily consumption of tap water as plain drinking water and as heated tap water, e.g. in coffee and tea, was 0.86 +/- 0.48 l and 0.94 +/- 0.69 l, respectively.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	33-36
17176821-5	2006	The average daily consumption of tap water as plain drinking water and as heated tap water, e.g. in coffee and tea, was 0.86 +/- 0.48 l and 0.94 +/- 0.69 l, respectively.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	33-36
17176821-6	2006	Women consumed more cold tap water than did men, while men appeared to have a higher consumption of heated tap water.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
17176821-7	2006	Cold tap water intake was highest in the oldest age group, (&gt; or =70 years).	Water	9-14	nuclear RNA export factor 1	Homo sapiens	5-8
17006975-10	2006	The water extract of DG strongly increased the activities of CYP2D6 and 3A and the water extract of DH significantly increased the activity of 2D6.	Water	4-9	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	61-67
16949774-2	2006	Consequently, DRSP, when combined with 17beta-estradiol (E2) as hormone replacement therapy (HRT), offsets E2-related water and sodium retention by blocking the mineralocorticoid receptor.	Water	118-123	pinin, desmosome associated protein	Homo sapiens	14-18
17057854-0	2006	A sugar-quinoline fluorescent chemosensor for selective detection of Hg2+ ion in natural water.	Water	89-94	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	69-72
17057854-1	2006	A selective and sensitive fluorescent sensor for detection of Hg2+ in natural water was achieved by incorporating the well-known fluorophore quinoline group and a water-soluble D-glucosamine group within one molecule.	Water	78-83	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	62-65
17057854-1	2006	A selective and sensitive fluorescent sensor for detection of Hg2+ in natural water was achieved by incorporating the well-known fluorophore quinoline group and a water-soluble D-glucosamine group within one molecule.	Water	163-168	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	62-65
17083230-9	2006	The remaining four coordination sites on Ca(II) in 1 come from two coordinated water molecules and a chelating carboxylate bridging from an adjacent [Ca(PDA)(H2O)2].2H2O complex.	Water	79-84	carbonic anhydrase 2	Homo sapiens	41-47
16832639-1	2006	To investigate if spa water is superior to tap water (TW) in relieving the symptoms of pain, joint motion, life quality in knee osteoarthritis (KOA) patients.	Water	22-27	surfactant protein A2	Homo sapiens	18-21
17288152-1	2006	A novel technique of liquid phase microextraction supported by hollow fiber membrane (LPME-HFM) was applied to extract tramadol in tap water, urine and human plasma.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	131-134
17042492-2	2006	Fet3p is a ferroxidase that, like ceruloplasmin and hephaestin, couples the oxidation of 4 equiv of Fe(II) to the reduction of O2 to 2 H2O.	Water	135-138	ferroxidase	Saccharomyces cerevisiae S288C	11-22
16990636-4	2006	In phase B, tap water and the concentration that yielded the best pellet delivery from phase A were used with the narrower size 8 and shorter size 20 French tubes.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
16609148-0	2006	Galphaq-dependent signaling cascades stimulate water-seeking behavior.	Water	47-52	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	0-7
16645161-10	2006	The data suggested that IL-1beta reduces LES tone by producing H(2)O(2), which may affect Ca(2+)-release mechanisms and increase the synthesis of COX-2 and PGE(2).	Water	63-68	cytochrome c oxidase subunit II	Felis catus	146-151
17025346-1	2006	The molecular weight dependence of poly(L-lactide)/poly(D-lactide) (PLLA/PDLA) stereocomplex behavior at the air-water interface was studied by surface pressure-area (pi-A) isotherms and atomic force microscopy (AFM).	Water	113-118	PDON2	Homo sapiens	73-77
17025346-2	2006	It was found that the compression-induced sterecomplexation of a PDLA/PLLA equimolar blend with high molecular weight (M(w) = 1 x 10(6) and 9.8 x 10(5), respectively) could occur at the air-water interface.	Water	190-195	PDON2	Homo sapiens	65-69
17025346-5	2006	AFM images clearly disclosed for the first time the morphological changes of the equimolar blends of PLLA and PDLA at the air-water interface induced by increasing the surface pressure of the monolayer.	Water	126-131	PDON2	Homo sapiens	110-114
16982516-1	2006	Iodoacetic and chloroiodoacetic acids were formed when municipal chlorinated tap water was allowed to react with iodized (with potassium iodide) table salt or with potassium iodide itself.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
17003437-4	2006	METHODS: EAU was induced in OPN-null and wild-type (WT) mice by immunization with interphotoreceptor retinoid-binding protein (IRBP).	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	82-125
17003437-4	2006	METHODS: EAU was induced in OPN-null and wild-type (WT) mice by immunization with interphotoreceptor retinoid-binding protein (IRBP).	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	127-131
16871511-9	2006	In contrast, complexes with a cis-alpha topology, such as [Fe(bpmen)X2] and [Fe(alpha-bpmcn)(OTf)2], can catalyze both epoxidation and cis-dihydroxylation through a water-assisted mechanism.	Water	165-170	POU class 2 homeobox 2	Homo sapiens	93-98
16871511-10	2006	Surprisingly, [Fe(bpmpn)X2] and [Fe(beta-bpmcn)(OTf)2] catalyze epoxidation via a water-assisted pathway and cis-dihydroxylation via a non-water-assisted mechanism, a result that requires two independent and distinct oxidants.	Water	82-87	POU class 2 homeobox 2	Homo sapiens	48-53
16871511-10	2006	Surprisingly, [Fe(bpmpn)X2] and [Fe(beta-bpmcn)(OTf)2] catalyze epoxidation via a water-assisted pathway and cis-dihydroxylation via a non-water-assisted mechanism, a result that requires two independent and distinct oxidants.	Water	139-144	POU class 2 homeobox 2	Homo sapiens	48-53
17593398-1	2007	The aquaporin 4 (AQP4) water channel is present on the sarcolemma of fast-twitch-type skeletal myofibres.	Water	23-28	aquaporin 4	Homo sapiens	4-15
17593398-1	2007	The aquaporin 4 (AQP4) water channel is present on the sarcolemma of fast-twitch-type skeletal myofibres.	Water	23-28	aquaporin 4	Homo sapiens	17-21
17697181-9	2007	In particular, exposure of the contact lenses to tap water or other sources of water should be avoided.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
17697181-9	2007	In particular, exposure of the contact lenses to tap water or other sources of water should be avoided.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	49-52
16901639-2	2006	Intracerebroventricular (ICV) injection of chicken ghrelin inhibited water intake (WI) in chicks under both ad libitum and 17-h water-deprived drinking conditions at doses ranging from 0.01 to 0.1nmol/chick.	Water	69-74	ghrelin/obestatin prepropeptide	Gallus gallus	51-58
18037771-1	2007	Uroguanylin (gene name: guanylate cyclase activator 2B, GUCA2B) is a peptide regulator of intestinal salt and water transport.	Water	110-115	guanylate cyclase activator 2B	Homo sapiens	0-11
32731068-0	2020	Using water quality and isotope studies to inform research in chronic kidney disease of unknown aetiology endemic areas in Sri Lanka.	Water	6-11	sorcin	Homo sapiens	123-126
18037771-1	2007	Uroguanylin (gene name: guanylate cyclase activator 2B, GUCA2B) is a peptide regulator of intestinal salt and water transport.	Water	110-115	guanylate cyclase activator 2B	Homo sapiens	24-54
18037771-1	2007	Uroguanylin (gene name: guanylate cyclase activator 2B, GUCA2B) is a peptide regulator of intestinal salt and water transport.	Water	110-115	guanylate cyclase activator 2B	Homo sapiens	56-62
16901639-2	2006	Intracerebroventricular (ICV) injection of chicken ghrelin inhibited water intake (WI) in chicks under both ad libitum and 17-h water-deprived drinking conditions at doses ranging from 0.01 to 0.1nmol/chick.	Water	128-133	ghrelin/obestatin prepropeptide	Gallus gallus	51-58
33255239-0	2020	Adrenomedullin Inhibits Osmotic Water Permeability in Rat Inner Medullary Collecting Ducts.	Water	32-37	adrenomedullin	Rattus norvegicus	0-14
16968056-3	2006	Recoveries of cyanidin-3-glucoside (C3G) were 91% from water, 71% from plasma, and 81% from urine.	Water	55-60	Rap guanine nucleotide exchange factor 1	Homo sapiens	14-39
33255239-2	2020	However, the direct effect of ADM on osmotic water permeability in the rat inner medullary collecting duct (IMCD) has not been tested.	Water	45-50	adrenomedullin	Rattus norvegicus	30-33
21631794-15	2007	For chronic wounds, the relative risk of developing an infection when cleansed with tap water compared with normal saline was 0.16 (95% CI 0.01-2.96).	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
16966822-3	2006	The tyrosinase attached to the nanogold continued to react with substrates in AN even when the water content was lower than 0.01 w/w%.	Water	95-100	tyrosinase	Homo sapiens	4-14
21631794-21	2007	Conclusions  Although the evidence is limited one trial has suggested that the use of tap water to cleanse acute wounds reduces the infection rate and other trials conclude that there is no difference in the infection and healing rates between wounds that were not cleansed and those cleansed with tap water and other solutions.	Water	90-95	nuclear RNA export factor 1	Homo sapiens	86-89
33255239-6	2020	Adding ADM (100 nM) to the bath significantly decreased osmotic water permeability.	Water	64-69	adrenomedullin	Rattus norvegicus	7-10
33255239-9	2020	However, inhibition of cAMP by SQ22536 further decreased ADM-attenuated osmotic water permeability.	Water	80-85	adrenomedullin	Rattus norvegicus	57-60
33255239-10	2020	Stimulation of cAMP by roflumilast increased ADM-attenuated osmotic water permeability.	Water	68-73	adrenomedullin	Rattus norvegicus	45-48
17724188-1	2007	PURPOSE: Recent studies have shown that rabbit corneal keratocytes abundantly express two water-soluble proteins, transketolase (TKT) and aldehyde dehydrogenase class 1A1 (ALDH1A1), in vivo and that these proteins may contribute to corneal transparency at the cellular level.	Water	90-95	aldehyde dehydrogenase 1A1	Oryctolagus cuniculus	138-170
16545423-2	2006	Laboratory experiments were conducted to investigate the birnessite (delta-MnO(2))-promoted debromination of BDE-209 in tetrahydrofuran (THF)-water systems as well as catechol solutions.	Water	142-147	homeobox D13	Homo sapiens	109-112
16545423-3	2006	Up to 100% (0.1044 micromol initial charge) of BDE-209 disappeared upon reaction with birnessite in THF/H(2)O (4:6-9:1).	Water	104-109	homeobox D13	Homo sapiens	47-50
17724188-1	2007	PURPOSE: Recent studies have shown that rabbit corneal keratocytes abundantly express two water-soluble proteins, transketolase (TKT) and aldehyde dehydrogenase class 1A1 (ALDH1A1), in vivo and that these proteins may contribute to corneal transparency at the cellular level.	Water	90-95	aldehyde dehydrogenase 1A1	Oryctolagus cuniculus	172-179
33255239-12	2020	We tested whether PLC pathways regulate ADM-attenuated osmotic water permeability.	Water	63-68	adrenomedullin	Rattus norvegicus	40-43
33255239-13	2020	Blockade of either PLC by U73122 or PKC by rottlerin significantly augmented the ADM-attenuated osmotic water permeability and promoted pS256-AQP2 but did change pS261-AQP2.	Water	104-109	adrenomedullin	Rattus norvegicus	81-84
17503006-11	2007	The MTHFR 677 any T genotype was suggested to have potentially more than multiplicative interactions with raw water drinking with p-value for adjusted interaction of 0.03.	Water	110-115	methylenetetrahydrofolate reductase	Homo sapiens	4-9
17367032-7	2006	In the in vitro experiment, Periogard exhibited the greatest inhibition halo average, followed by the experimental solution, Brushtox, and sterile tap water (P&lt;.05).	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
17367032-8	2006	CONCLUSIONS: After a single brushing, severe contamination by mutans streptococci colonies/biofilms was observed on all toothbrushes sprayed with sterile tap water (control).	Water	158-163	nuclear RNA export factor 1	Homo sapiens	154-157
17503006-13	2007	The polymorphism of MTHFR 677 might modify the effects of raw water drinking on the risk of primary hepatocellular carcinoma.	Water	62-67	methylenetetrahydrofolate reductase	Homo sapiens	20-25
33255239-16	2020	ADM reduced water reabsorption through a PLC-pathway involving PKC.	Water	12-17	adrenomedullin	Rattus norvegicus	0-3
33255239-17	2020	ADM-attenuated water reabsorption may be related to decreased trafficking of AQP2 to the plasma membrane.	Water	15-20	adrenomedullin	Rattus norvegicus	0-3
33391965-4	2020	We find that AR column integrated water vapor (IWV) is especially sensitive to SST and increases by 6.3-9.7% per degree warming despite decreasing relative humidity through much of the column.	Water	34-39	somatostatin	Homo sapiens	79-82
17822074-0	2007	Lead levels high in Canadian tap water.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
17899684-1	2007	Aquaporin-4 (AQP-4) is a water channel protein located on the plasma membrane of astrocytes and is regulated under various conditions.	Water	25-30	aquaporin 4	Homo sapiens	0-11
16713083-5	2006	Water is used as a safe and environmentally friendly solvent in MAE for PCB and CBz analyses and MAE has high extraction efficiency for spiked fly ash compared with that of SE.	Water	0-5	Pyruvate carboxylase	Drosophila melanogaster	72-75
17899684-1	2007	Aquaporin-4 (AQP-4) is a water channel protein located on the plasma membrane of astrocytes and is regulated under various conditions.	Water	25-30	aquaporin 4	Homo sapiens	13-18
32641662-0	2020	Non-tuberculous Mycobacterial Pseudo-outbreak of an Intestinal Culture Specimen Caused by a Water Tap in an Endoscopy Unit.	Water	92-97	nuclear RNA export factor 1	Homo sapiens	98-101
17506534-0	2007	pKa analysis for the zinc-bound water in human carbonic anhydrase II: Benchmark for "multiscale" QM/MM simulations and mechanistic implications.	Water	32-37	carbonic anhydrase 2	Homo sapiens	47-68
17506534-3	2007	The pKa of the zinc-bound water, calculated with a SCC-DFTB/MM-GSBP based thermodynamic integration approach, agrees well with experiments for the wild type CAII.	Water	26-31	carbonic anhydrase 2	Homo sapiens	157-161
16845476-8	2006	In addition, we detected a polar localization of ZmPIP2;5 to the external periclinal side of epidermal cells in root apices, suggesting an important role in water uptake from the root surface.	Water	157-162	aquaporin PIP2-5	Zea mays	49-57
16898759-0	2006	Conformational equilibrium of 1,2-dichloroethane in water: comparison of PCM and RISM-SCF methods.	Water	52-57	KIT ligand	Homo sapiens	86-89
32641662-8	2020	NTM were detected in the tap water used to prepare the antifoaming solution in the endoscopy unit.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
33184334-7	2020	A total nitrogen instrument (TNM-1) was used to study the urea release from single- and double-layered hollow nanofibres yarn in water.	Water	129-134	teneurin transmembrane protein 1	Homo sapiens	29-34
16822623-11	2006	Finally, we found that Asr1 activation under water stress is not conserved between Lycopersicon species.	Water	45-50	abscisic stress-ripening protein 1	Solanum lycopersicum	23-27
17392324-8	2007	Treatment with KGF decreased the leak of both markers and decreased the level of extravascular lung water in sensitised rats challenged with OVA.	Water	100-105	fibroblast growth factor 7	Rattus norvegicus	15-18
33333471-1	2020	Neuromyelitis optica spectrum disorder (NMOSD) is a disabling autoimmune astrocytopathic channelopathy, characterized by the presence of pathogenic antibodies to aquaporin-4 (AQP-4) water channels.	Water	182-187	aquaporin 4	Homo sapiens	162-173
17296768-19	2007	Phase 3 ADG was improved (P &lt; 0.01) by water acidification across all diets.	Water	42-47	ADG	Sus scrofa	8-11
17532793-0	2007	Identification of central nervous system sites involved in the water diuresis response elicited by central microinjection of nociceptin/ Orphanin FQ in conscious rats via c-Fos and inducible cAMP early repressor immunocytochemistry.	Water	63-68	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	171-176
17723578-6	2006	Half-lives values obtained for model ultrapure water solutions were in good agreement with those observed in tap water samples.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	109-112
17723578-6	2006	Half-lives values obtained for model ultrapure water solutions were in good agreement with those observed in tap water samples.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
17723578-9	2006	Both species were also generated after the addition of parabens to chlorinated tap water.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
17723578-11	2006	They were identified as bromo- and bromochloro-parabens, formed due to the existence of traces of bromide in tap water sources.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
17723578-12	2006	Experiments carried out by mixing paraben-containing personal care products with tap water, containing free chlorine, confirmed the formation of all above described halogenated by-products.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
33333471-1	2020	Neuromyelitis optica spectrum disorder (NMOSD) is a disabling autoimmune astrocytopathic channelopathy, characterized by the presence of pathogenic antibodies to aquaporin-4 (AQP-4) water channels.	Water	182-187	aquaporin 4	Homo sapiens	175-180
16574943-4	2006	The results have revealed that ROS levels, vascular endothelial growth factor (VEGF) expression, hypoxia-inducible factor-1alpha protein level, airway hyperresponsiveness, and vascular permeability are increased after inhalation of H(2)O(2).	Water	232-237	vascular endothelial growth factor A	Mus musculus	43-77
32706134-0	2020	Water-Induced Structural Dynamic Process in Molecular Sieve under Mild Hydrothermal Conditions: A Novel Ship-in-Bottle Strategy for Acidity Identification and Catalyst Modification.	Water	0-5	inositol polyphosphate-5-phosphatase D	Homo sapiens	104-108
16712780-0	2006	Aquaporin-5 water channel in lipid rafts of rat parotid glands.	Water	12-17	aquaporin 5	Rattus norvegicus	0-11
16712780-1	2006	Aquaporin-5 (AQP5), an apical plasma membrane (APM) water channel in salivary glands, lacrimal glands, and airway epithelium, has an important role in fluid secretion.	Water	52-57	aquaporin 5	Rattus norvegicus	0-11
16712780-1	2006	Aquaporin-5 (AQP5), an apical plasma membrane (APM) water channel in salivary glands, lacrimal glands, and airway epithelium, has an important role in fluid secretion.	Water	52-57	aquaporin 5	Rattus norvegicus	13-17
17490771-6	2007	The probability of detecting positive samples was 50% (the critical level of detection) when 2 l samples of tap water were inoculated with 0.7 log PFU of HAV, 25 g samples of iceberg lettuce were inoculated with 1.0 log PFU of HAV, and 25 g samples of fresh and frozen raspberries were inoculated with 1.0 and 1.5 log PFU of HAV, respectively.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
32497862-6	2020	Small volume water droplets (5 muL) on the PEG9-12-Si/TEOS hybrid film (static water contact angle (CA) of ~40 ) at a 90 -inclined surface could slide at an average speed of 3.4 mm/sec without pinning and tailing, which was about twice as fast as that on the PEG6-9-Si/TEOS hybrid film surface (1.5 mm/sec, static water CA of ~40 ), in spite of having similar static hydrophilic nature.	Water	13-18	IGF2 antisense RNA	Homo sapiens	259-265
17717924-4	2007	RESULTS: In the groups of mouse stressed by water platform environment, the level of serum glucocorticoid, the TFAR-19 protein expression and the Annexin-V apoptosis protein proportion increased in the thymus cell along with the stress time prolonging (P&lt;0.05 or P &lt;0.01).	Water	44-49	annexin A5	Mus musculus	146-155
16856835-5	2006	For example, AKAP-PKA interactions are essential for the vasopressin-mediated water re-absorption in renal collecting duct principal cells or beta-adrenoceptor-induced increases in cardiac myocyte contractility.	Water	78-83	A-kinase anchoring protein 1	Homo sapiens	13-17
32227362-0	2020	Prevalence and seasonal variation of Acanthamoeba in domestic tap water in greater Sydney, Australia.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
16946558-6	2006	Furthermore, uptake of fexofenadine by Xenopus oocytes expressing rat oatp3 was significantly greater than that by water-injected oocytes, and the affinity of oatp3 for fexofenadine (Km) was about 60 microM, which is comparable with the value obtained by the Ussing chamber method using rat intestinal tissues.	Water	115-120	solute carrier organic anion transporter family, member 1A5	Rattus norvegicus	159-164
17353022-2	2007	After a general review of the principles of supercritical fluid extraction (SFE) and pressurized liquid extraction (PLE; also called accelerated solvent extraction, ASE or subcritical water extraction, SWE, when water is employed as extraction solvent), the principal applications of such techniques in the mentioned fields of food and natural products are described, discussing their main advantages and drawbacks.	Water	212-217	arylsulfatase L	Homo sapiens	165-168
32227362-1	2020	BACKGROUND: This study examined the prevalence of free-living Acanthamoeba in domestic tap water in the greater Sydney region, Australia, and determined any seasonal variation in prevalence.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
16807403-0	2006	Increased water intake decreases progression of polycystic kidney disease in the PCK rat.	Water	10-15	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	81-84
16807403-4	2006	For suppression of the effect of AVP physiologically, water intake was increased in PCK rats, a model of PKD, and the effect on renal morphology, cellular mechanism, and function was determined.	Water	54-59	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	84-87
17089219-7	2007	The WOMAC activity, pain, and total scores improved significantly also in the tap water group at the end of the treatment course, but no improvement was detected at the end of the 3-month follow-up period.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
32227362-12	2020	CONCLUSION: The prevalence of free-living Acanthamoeba characterised morphologically in domestic tap water of the greater Sydney region was higher than expected, especially considering the low incidence of Acanthamoeba keratitis in Australia.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
16807403-5	2006	The addition of 5% glucose in the drinking water increased fluid intake approximately 3.5-fold compared with rats that received tap water.	Water	132-137	SEC14-like lipid binding 2	Rattus norvegicus	128-131
16807403-6	2006	In PCK rats, increased water intake for 10 wk reduced urinary AVP excretion (68.3%), and urine osmolality fell below 290 mOsmol/kg.	Water	23-28	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	3-6
32818823-4	2020	Here, we conducted targeted and non-targeted chemical analyses of sediment and drinking water in CKDu affected regions in Sri Lanka, one of the most affected countries.	Water	88-93	sorcin	Danio rerio	122-125
16807403-9	2006	Taken together, these data demonstrate that water intake that is sufficient to cause persistent water diuresis suppresses B-Raf/MEK/ERK activity and decreases cyst and renal volumes in PCK rats.	Water	44-49	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	185-188
16807403-9	2006	Taken together, these data demonstrate that water intake that is sufficient to cause persistent water diuresis suppresses B-Raf/MEK/ERK activity and decreases cyst and renal volumes in PCK rats.	Water	96-101	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	185-188
16953177-2	2006	Tap water was electrolyzed in a water vessel using platinum cell technology.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
16953177-3	2006	The electrolyzed tap water (called Puri-water) was put in contact with five major periodontopathogens or toothbrushes contaminated with these bacteria for 30 sec.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
16953177-7	2006	Our results demonstrate that the electrolyzed tap water is effective as a mouthwash and for toothbrush disinfection.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
17503254-4	2007	Although urinary arsenic concentration increased with higher exposure in tap water, urinary 8-OHdG concentration did not differ by community within Arizona or Sonora, and was not associated with urinary arsenic concentration.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
17525198-2	2007	METHODS: EAU was induced in C57BL/6 (B6) mice by transfer of activated T cells specific for the interphotoreceptor-binding protein (IRBP) 1-20 peptide.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	96-130
17525198-2	2007	METHODS: EAU was induced in C57BL/6 (B6) mice by transfer of activated T cells specific for the interphotoreceptor-binding protein (IRBP) 1-20 peptide.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	132-136
32783417-4	2020	CSF guided to the perivascular space around the arteries enters the interstitium of brain tissue via aquaporin-4 water channels to clear waste proteins into the perivascular space around the veins before being drained from the brain.	Water	113-118	aquaporin 4	Homo sapiens	101-112
17645239-7	2007	These immunohistochemical results indicate that the expression not only of AQP4 but also of AQP1 was enhanced in MS and ischemic brain lesions located predominantly in astrocytes, suggesting a pivotal role of astrocytic AQP in the maintenance of water homeostasis in the CNS under pathological conditions.	Water	246-251	aquaporin 4	Homo sapiens	75-79
16729339-1	2006	The dissociation mechanism of a water molecule at an oxygen vacancy on the MgO(100) surface was studied by using the embedded cluster method at the DFT/B3 LYP level, while the energetic information was refined by using the IMOMO method at the CCSD level.	Water	32-37	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	155-158
33312665-1	2020	The research focused on assessing the risk to human health resulting from the content of selected Cr, Co, Mn, Cu, Ni, Pb, As, Zn and Sr metals in tap water supplied by Upper Silesia Water Plant to the inhabitants of the Upper Silesia region (Poland).	Water	150-155	nuclear RNA export factor 1	Homo sapiens	146-149
16426624-4	2006	Thus, the experimental lnk versus phi curve, where k is the retention factor of a sample solute under isocratic conditions and phi is the volume fraction of the organic modifier in the water-organic mobile phase, is subdivided into a finite number of linear portions resulting in simple analytical expressions for the solute gradient retention time.	Water	185-190	SH2B adaptor protein 3	Homo sapiens	23-26
17347837-2	2007	This distribution suggests that AQP4 controls water fluxes into and out of the brain parenchyma.	Water	46-51	aquaporin 4	Mus musculus	32-36
33312665-1	2020	The research focused on assessing the risk to human health resulting from the content of selected Cr, Co, Mn, Cu, Ni, Pb, As, Zn and Sr metals in tap water supplied by Upper Silesia Water Plant to the inhabitants of the Upper Silesia region (Poland).	Water	182-187	nuclear RNA export factor 1	Homo sapiens	146-149
17347837-6	2007	In cytotoxic edema, AQP4 deletion slows the rate of water entry into brain, whereas in vasogenic edema, AQP4 deletion reduces the rate of water outflow from brain parenchyma.	Water	52-57	aquaporin 4	Mus musculus	20-24
17347837-6	2007	In cytotoxic edema, AQP4 deletion slows the rate of water entry into brain, whereas in vasogenic edema, AQP4 deletion reduces the rate of water outflow from brain parenchyma.	Water	138-143	aquaporin 4	Mus musculus	104-108
33312665-6	2020	The chronic daily intake (CDI), hazard quotient (HQ) and hazard index (HI) results for non-carcinogenic risk assessment of metals in tap water has been assessed.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
16494987-7	2006	As expected, expression of human T2R4 or its mouse ortholog T2R8 in ASI neurons counteracted the water-soluble avoidance to 6-n-propyl-2-thiouracil and denatoniun observed in control wild-type worms.	Water	97-102	taste receptor, type 2, member 108	Mus musculus	60-64
33312665-9	2020	HI values were also less than 1, that meaning that the analyzed tap water is safe for human consumption.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
33312665-10	2020	The concentration of As, Cr, Cu, Mn and Ni in analyzed tap water is in accordance with Polish and international requirements.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
33082440-4	2020	Triclosan (an antimicrobial agent) and 4-octylphenol (a plasticizer) were only detected in the tap water (up to 9.74 and 0.44 ng/L, respectively).	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
16452917-17	2006	Households with tube well water had the worst BMI compared with those with tap water (P&lt;0.001).	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
17538754-12	2007	The prevalence of infection among people who drank water from wells was 92 percent compared with 74.8 percent of those who drank tap water (p-value is less than 0.001).	Water	133-138	nuclear RNA export factor 1	Homo sapiens	129-132
33082440-6	2020	Bisphenol A was observed to be highest in tap water at 66.40 ng/L (detection: 100%; median concentration: 0.28 ng/L).	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
17713265-1	2007	Water-soluble CdTe quantum dots synthesized in aqueous solution have been conjugated with peptide LyP-1 using N-Succinimidyl 3-[2-pyridyldithio]-propionate (SPDP) as a cross-linking reagent.	Water	0-5	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	98-103
16740415-9	2006	Isolates from patients showed a similar distribution of genotypes as did tap water isolates, and strains of identical genotype as patient strains had been isolated previously from tap water outlets in 8 out of 16 (50%) infection or colonization episodes.	Water	184-189	nuclear RNA export factor 1	Homo sapiens	180-183
33082440-7	2020	There was a significant difference in triclosan contamination between the river and tap water (p < 0.001).	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
32563866-0	2020	The identification of halogenated disinfection by-products in tap water using liquid chromatography-high resolution mass spectrometry.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
16252072-4	2006	We demonstrated that 1) hippocampal BDNF mRNA and protein levels were both elevated in response to exercise training at 2 h after the last run but not after 2 d; 2) an acute moderate exercise (1 or 3 d) increased BDNF protein levels; 3) acute severe exercise increased BDNF protein and mRNA levels in animals under a familiarization regimen, while suppressed the BDNF mRNA level in rats without treadmill familiarization, paralleling the stress effect of immobilization/water exposure.	Water	470-475	brain-derived neurotrophic factor	Rattus norvegicus	36-40
17521416-0	2007	Hygienic safety of reusable tap water filters (Germlyser) with an operating time of 4 or 8 weeks in a haematological oncology transplantation unit.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
17521416-1	2007	BACKGROUND: Microbial safe tap water is crucial for the safety of immunosuppressed patients.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
17521416-10	2007	Using a validated reprocessing in a washer/disinfector with alkaline, acid treatment and thermic disinfection, the filters were effectively reprocessable and now provide tap water meeting the German drinking water regulations as well as the WHO guidelines, including absence of pathogens.	Water	174-179	nuclear RNA export factor 1	Homo sapiens	170-173
17521416-10	2007	Using a validated reprocessing in a washer/disinfector with alkaline, acid treatment and thermic disinfection, the filters were effectively reprocessable and now provide tap water meeting the German drinking water regulations as well as the WHO guidelines, including absence of pathogens.	Water	208-213	nuclear RNA export factor 1	Homo sapiens	170-173
16778375-4	2006	Recently, the disease-specific antibody (NMO-IgG) was found in the serum from NMO patients, and its target antigen was identified as aquaporin-4 (AQP4) water channel protein which is mainly expressed in astroglial foot processes.	Water	152-157	aquaporin 4	Homo sapiens	133-144
32563866-1	2020	In this paper, a comprehensive method for the identification of the unknown halogenated DBPs (X-DBPs, X = Cl, Br, and I) in the tap water of Wuhan, China via liquid chromatography-high resolution mass spectrometry (LC-HRMS) was developed.	Water	132-137	nuclear RNA export factor 1	Homo sapiens	128-131
16778375-4	2006	Recently, the disease-specific antibody (NMO-IgG) was found in the serum from NMO patients, and its target antigen was identified as aquaporin-4 (AQP4) water channel protein which is mainly expressed in astroglial foot processes.	Water	152-157	aquaporin 4	Homo sapiens	146-150
33072165-8	2020	We detected a set of candidate genes, pathways, and GO categories related to oxidative stress, water reabsorption, immune regulation, energy metabolism, eye protection, heat stress, respiratory system adaptation, prevention of high blood pressure, and DNA damage and repair that may directly or indirectly be involved in the adaptation of TRD to an arid-desert environment.	Water	95-100	T cell receptor delta locus	Homo sapiens	339-342
17044511-4	2006	Water quality also had a significant effect, with a decreasing degradation rate of chlorpyrifos in the sequence of distilled water &gt; tap water &gt; river water &gt; lake wate &gt; paddy water.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	136-139
17044511-4	2006	Water quality also had a significant effect, with a decreasing degradation rate of chlorpyrifos in the sequence of distilled water &gt; tap water &gt; river water &gt; lake wate &gt; paddy water.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	136-139
17439275-1	2007	Replacing the counterion in sodium bis(2-ethylhexyl)sulfosuccinate (NaOT, usually known as AOT or Aerosol OT) with H+ (HOT) allows strongly acidic microemulsions to be obtained through the effect of a change in the solvation mechanism of the surfactant, where the Na+...OH2 interaction is displaced by a stronger H+...OH2 interaction.	Water	270-273	alcohol dehydrogenase iron containing 1	Homo sapiens	119-122
17439275-1	2007	Replacing the counterion in sodium bis(2-ethylhexyl)sulfosuccinate (NaOT, usually known as AOT or Aerosol OT) with H+ (HOT) allows strongly acidic microemulsions to be obtained through the effect of a change in the solvation mechanism of the surfactant, where the Na+...OH2 interaction is displaced by a stronger H+...OH2 interaction.	Water	318-321	alcohol dehydrogenase iron containing 1	Homo sapiens	119-122
17439275-4	2007	In HOT microemulsions, the disparate strength of Na+...OH2 and H+...OH2 interactions results in a decrease in the resonance signal for the hydrogen atoms in the water molecules from delta approximately 8.6 ppm at W = 2 to delta approximately 4.9 ppm at W = 50.	Water	55-58	alcohol dehydrogenase iron containing 1	Homo sapiens	3-6
17439275-4	2007	In HOT microemulsions, the disparate strength of Na+...OH2 and H+...OH2 interactions results in a decrease in the resonance signal for the hydrogen atoms in the water molecules from delta approximately 8.6 ppm at W = 2 to delta approximately 4.9 ppm at W = 50.	Water	161-166	alcohol dehydrogenase iron containing 1	Homo sapiens	3-6
17439275-5	2007	These changes in the physical properties of water alter chemical reactivity in a way that is clearly apparent in solvolytic processes in NaOT and HOT microemulsions.	Water	44-49	alcohol dehydrogenase iron containing 1	Homo sapiens	146-149
17439275-7	2007	The disparate behavior is a result of a decreased nucleophilicity of interfacial water in HOT microemulsions relative to NaOT microemulsions.	Water	81-86	alcohol dehydrogenase iron containing 1	Homo sapiens	90-93
17439275-8	2007	For a dissociative process the rate constants are greater in HOT microemulsions than in NaOT ones, and increase with increasing W in both types of microemulsions, which can be ascribed to an increased electrophilicity of interfacial water in HOT microemulsions.	Water	233-238	alcohol dehydrogenase iron containing 1	Homo sapiens	61-64
17439275-8	2007	For a dissociative process the rate constants are greater in HOT microemulsions than in NaOT ones, and increase with increasing W in both types of microemulsions, which can be ascribed to an increased electrophilicity of interfacial water in HOT microemulsions.	Water	233-238	alcohol dehydrogenase iron containing 1	Homo sapiens	242-245
16771406-0	2006	Photoelectrochemical decomposition of water into H2 and O2 on porous BiVO4 thin-film electrodes under visible light and significant effect of Ag ion treatment.	Water	38-43	relaxin 2	Homo sapiens	49-58
33098340-4	2020	Ultralow PFS concentrations (0.5 ng/L of PFOS; 0.4 ng/L of PFHxS) were detected in preconcentrated tap water containing PFSs.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
16571723-3	2006	We have examined the mechanism of regulatory volume decrease (RVD) in salivary gland cells and report a novel association between osmosensing TRPV4 (transient receptor potential vanalloid 4) and AQP5 (aquaporin 5), which is required for regulating water permeability and cell volume.	Water	248-253	aquaporin 5	Mus musculus	195-199
16571723-3	2006	We have examined the mechanism of regulatory volume decrease (RVD) in salivary gland cells and report a novel association between osmosensing TRPV4 (transient receptor potential vanalloid 4) and AQP5 (aquaporin 5), which is required for regulating water permeability and cell volume.	Water	248-253	aquaporin 5	Mus musculus	201-212
17363038-5	2007	The relatively low capacity in treating As-spiked tap water arose from the suppression of FeCO(3) dissolution in the presence of high HCO(3)(-) concentration (333 mg/L), which consequently limited the formation of fresh Fe(III) oxides.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
17363038-6	2007	However, the H(2)O(2)-conditioning greatly increased As adsorption capacity of the column for remediating As-spiked tap water.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
33195405-0	2020	Highlighting the Importance of Water Alkalinity Using Phosphate Buffer Diluted With Deionized, Double Distilled and Tap Water, in Lowering Oxidation Effects on Human Hemoglobin Ozonated at High Ozone Concentrations in vitro.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
16643833-1	2006	We describe a simple, rapid, and sensitive fluorescence method for measurement of aluminum (Al) in human biological fluids, in dialysis solutions, and in tap water, which uses 8-hydroxyquinoline for ion chelation.	Water	158-163	nuclear RNA export factor 1	Homo sapiens	154-157
33090502-2	2020	31P-MRS is frequently applied alongside other radiological examinations, many of which use various contrast agents that shorten relaxation times of water in conventional proton MR, for a better characterisation of cardiac function, or following prior computed tomography (CT).	Water	148-153	MROS	Homo sapiens	4-7
16751983-12	2006	Susceptibility to EAU is related to the intrinsic capacity to mount higher inflammatory reactions and increased production of anti-IRBP IgG2a isotype is not necessarily a marker of this immunologic profile.	Water	18-21	retinol binding protein 3, interstitial	Mus musculus	131-135
17456554-1	2007	OBJECTIVES: To compare wound infection rates for irrigation with tap water versus sterile saline before closure of wounds in the emergency department.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
17229810-5	2007	Expression of aqp-2, aqp-3, aqp-4, aqp-6, or aqp-7 in Xenopus oocytes increased water permeability five- to sevenfold.	Water	80-85	aquaporin 4 L homeolog	Xenopus laevis	28-33
17229810-5	2007	Expression of aqp-2, aqp-3, aqp-4, aqp-6, or aqp-7 in Xenopus oocytes increased water permeability five- to sevenfold.	Water	80-85	AQuaPorin or aquaglyceroporin related	Caenorhabditis elegans	45-50
16813019-3	2006	Consumer surveys usually stress two main factors: dissatisfaction with tap water organoleptics (especially taste) and health/risk concerns.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
33020393-6	2020	Moreover, in Bissau, the levels of faecal contamination in piped water increased from the holes to the consumer (tap/fountain).	Water	65-70	nuclear RNA export factor 1	Homo sapiens	113-116
18970612-7	2006	The application of the method to the analysis of water samples (tap and mineral water) gave accurate results based on recovery studies (93-106%).	Water	49-54	nuclear RNA export factor 1	Homo sapiens	64-67
32776367-4	2020	Because the oxygen molecule is paramagnetic, its production from or its reduction to diamagnetic hydroxide/water involves spin-related electron transfer.	Water	107-112	spindlin 1	Homo sapiens	122-126
16734752-8	2006	Two-thirds of filtered sodium and water are absorbed in the renal proximal tubule, a mechanism that intimately involves the apical sodium/hydrogen ion exchanger, NHE3.	Water	34-39	solute carrier family 9 member A3	Homo sapiens	162-166
16734761-3	2006	Emerging data suggest that TonEBP plays a key role in the urinary concentrating mechanism by stimulating the UT-A urea transporters and possibly AQP2 water channel.	Water	150-155	nuclear factor of activated T cells 5	Mus musculus	27-33
17253958-13	2007	The modes of actin involvement in chloroplast translocations are different in water and terrestrial angiosperms.	Water	78-83	actin-12	Arabidopsis thaliana	13-18
17378599-4	2007	In the present work, we developed water-soluble camptothecin (CPT) and doxorubicin (DOXO) prodrugs that incorporate the peptide linker Ala-Leu-Ala-Leu that serves as a substrate for the tumor-associated protease, cathepsin B, which is overexpressed in several solid tumors.	Water	34-39	cathepsin B	Homo sapiens	213-224
32556996-0	2020	National screening study investigating nine phthalates and one adipate in raw and treated tap water in France.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
17464434-4	2007	Consistent enhancement or a de novo production of sodium intake induced by deactivation of inhibitory nuclei (e.g., lateral parabrachial nucleus) or hormones (oxytocin, atrial natriuretic peptide), in water-deprived, extracellular-dehydrated or, contrary to tradition, intracellular-dehydrated rats, suggests that sodium appetite and thirst share more mechanisms than previously thought.	Water	201-206	natriuretic peptide A	Rattus norvegicus	169-195
16739799-7	2006	Data revealed that SO2 and NO were capable of promoting homogeneous reduction of Hg2+ to Hg0 with H2O being present.	Water	98-101	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	81-84
32556996-9	2020	In tap water, the most frequently detected compound was DBP, at a maximum concentration of 1300 ng/L.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
32846519-7	2020	Acetone and water extracts demonstrated also higher cytotoxic potential in cell viability assays (SRB and MTT) using Caco-2 cells.	Water	12-17	chaperonin containing TCP1 subunit 4	Homo sapiens	98-101
16678050-1	2006	OBJECTIVE: To report the development of a new water-soluble paclitaxel-hyaluronic acid bioconjugate, HYTAD1-p20, for intravesical treatment of superficial bladder cancer.	Water	46-51	tubulin polymerization promoting protein family member 3	Homo sapiens	108-111
17351712-4	2007	Exposure of a CPD photolyase solution to UV-C (254 nm) reduced enzyme activity and induced accumulation of H(2)O(2).	Water	107-112	deoxyribodipyrimidine photo-lyase-like	Cucumis sativus	14-28
33095189-3	2020	In order to make up for this deficiency, tap water was selected to carry out RBW and PBW experiments independently.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
17452650-1	2007	Water autoionization reaction 2H2O --&gt; H3O- + OH- is a textbook process of basic importance, resulting in pH = 7 for pure water.	Water	0-5	H3 clustered histone 15	Homo sapiens	42-45
17452650-1	2007	Water autoionization reaction 2H2O --&gt; H3O- + OH- is a textbook process of basic importance, resulting in pH = 7 for pure water.	Water	125-130	H3 clustered histone 15	Homo sapiens	42-45
17452650-4	2007	Because H3O+ does, but OH- does not, display preference for surface sites, the H2O surface is predicted to be acidic with pH &lt; 4.8.	Water	79-82	H3 clustered histone 15	Homo sapiens	8-11
16256131-8	2006	When the WH/WS ratio was between 0.60 and 0.64, (C11)nG10 formed microemulsions and lyotropic liquid crystals in the presence of water and the oils.	Water	129-134	RNA polymerase III subunit K	Homo sapiens	49-52
33095189-4	2020	The quality changes of RBW and PBW show very similar trends that are not as great as might be imagined, and both are impacted by the tap water quality and the physiochemical effects.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
33095189-6	2020	The results show that tap water will be still safe and potable after being frequently boiled or after having undergone prolonged boiling, as long as it satisfies the sanitary standards of drinking water prior to heating.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
17454886-6	2007	CONCLUSIONS: CNP plasma levels appear to play a role in the water-sodium balance regulation in patients with pre-ascitic cirrhosis.	Water	60-65	natriuretic peptide C	Homo sapiens	13-16
16306129-6	2006	U937-ecoR cells expressing increased levels of TRPM2-L were treated with H(2)O(2) or TNF-alpha, and these cells exhibited significantly increased intracellular calcium concentration ([Ca(2+)](i)), decreased viability, and increased apoptosis.	Water	73-78	transient receptor potential cation channel subfamily M member 2	Homo sapiens	47-54
33095189-6	2020	The results show that tap water will be still safe and potable after being frequently boiled or after having undergone prolonged boiling, as long as it satisfies the sanitary standards of drinking water prior to heating.	Water	197-202	nuclear RNA export factor 1	Homo sapiens	22-25
33004844-0	2020	Transcriptional modulation of AREB-1 by CRISPRa improves plant physiological performance under severe water deficit.	Water	102-107	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	30-36
16760588-1	2006	A target value for iminoctadine triacetate residues in tap water was set at 6 microg/l in Japan.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
16760598-7	2006	Tap water samples from a laboratory were successfully analyzed using the proposed method.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
17650618-2	2007	It was found that, in Wistar rats the content of Hyal-1 mRNA was higher in the medulla than in other kidney zones at the normal water and food regimen.	Water	128-133	hyaluronidase 1	Rattus norvegicus	49-55
17375940-5	2007	Importantly, the phase diagram of F88/P85 mixtures in water was elucidated and showed the destabilization of the HC phase upon addition of small amounts of F88.	Water	54-59	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	38-41
33004844-4	2020	Particularly under water deprivation conditions, the abscisic acid-responsive element-binding protein AREB1/ABF2 plays an important role in drought stress response and physiological adaptation.	Water	19-24	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	102-107
16827181-4	2006	The terminal volume of tap water in copper and steel water pipes should be not less than 0.1 liter, whereas that in plastic water pipes should be not less than 1 liter.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
16827181-4	2006	The terminal volume of tap water in copper and steel water pipes should be not less than 0.1 liter, whereas that in plastic water pipes should be not less than 1 liter.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	23-26
33004844-4	2020	Particularly under water deprivation conditions, the abscisic acid-responsive element-binding protein AREB1/ABF2 plays an important role in drought stress response and physiological adaptation.	Water	19-24	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	108-112
16827181-4	2006	The terminal volume of tap water in copper and steel water pipes should be not less than 0.1 liter, whereas that in plastic water pipes should be not less than 1 liter.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	23-26
33004844-5	2020	In this investigation, we provide substantial confirmation for the role of AREB1/ABF2 in plant survival under severe water deficit using the CRISPR activation (CRISPRa) technique to enhance the AREB1 gene expression.	Water	117-122	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	75-80
33004844-5	2020	In this investigation, we provide substantial confirmation for the role of AREB1/ABF2 in plant survival under severe water deficit using the CRISPR activation (CRISPRa) technique to enhance the AREB1 gene expression.	Water	117-122	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	81-85
33004844-5	2020	In this investigation, we provide substantial confirmation for the role of AREB1/ABF2 in plant survival under severe water deficit using the CRISPR activation (CRISPRa) technique to enhance the AREB1 gene expression.	Water	117-122	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	194-199
32936152-3	2020	For cationic reverse micelles, we find that the absorption at frequencies >2500 cm-1 is dominated by asymmetric proton-hydration structures in which one of the OH groups of H3O+ is more weakly hydrogen-bonded to water than the other two OH groups.	Water	212-217	H3 clustered histone 15	Homo sapiens	173-176
16583822-0	2006	Characteristics of biofilm community formed in the chlorinated biodegradable organic matter-limited tap water.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
16798777-1	2006	The plasma membrane of skeletal muscles contains water channels such as aquaporin 4 (AQP4), aquaporin 3 (AQP3) and aquaporin 7 (AQP7).	Water	49-54	aquaporin 7	Rattus norvegicus	128-132
17108007-9	2007	ERK inhibitor PD98059 was found previously to inhibit AP-1 activation by H(2)O(2).	Water	73-78	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-58
17377785-5	2007	Tap water and surface water samples collected from our laboratory and Wohushan reservoir, respectively, were successfully analyzed using the proposed method.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
33134185-4	2020	This process is facilitated in part by aquaporin-4 (AQP4) water channels located primarily on astrocytic end feet that abut cerebral endothelial cells of the blood brain barrier.	Water	58-63	aquaporin 4	Homo sapiens	39-50
17250866-6	2007	This phenomenon was observed not only in the filtration of carbonate solution, but also in the filtration of the NaCl solution and the tap water.	Water	139-144	nuclear RNA export factor 1	Homo sapiens	135-138
16357103-2	2006	SULT2A1 is a liver- and intestine-expressed sulfo-conjugating enzyme that converts the alcohol-OH of neutral steroids, bile acids, and drugs to water-soluble sulfated metabolites.	Water	144-149	sulfotransferase family 2A member 1	Homo sapiens	0-7
33134185-4	2020	This process is facilitated in part by aquaporin-4 (AQP4) water channels located primarily on astrocytic end feet that abut cerebral endothelial cells of the blood brain barrier.	Water	58-63	aquaporin 4	Homo sapiens	52-56
16608596-14	2006	RESULTS: Tap water was the poorest cleaning solution, while UltraDose was the most effective.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
32989244-5	2021	Gng8 KO mice exhibited deficiency in learning and memory in passive avoidance and Morris water maze tests.	Water	89-94	guanine nucleotide binding protein (G protein), gamma 8	Mus musculus	0-4
16582847-15	2006	MRI grading score showed significant differences between the OP-1 and lactose groups at the 8, 12, and 24-week times, suggesting an increase in water content in the nucleus pulposus of the OP-1 group.	Water	144-149	bone morphogenetic protein 7	Homo sapiens	61-65
16582847-15	2006	MRI grading score showed significant differences between the OP-1 and lactose groups at the 8, 12, and 24-week times, suggesting an increase in water content in the nucleus pulposus of the OP-1 group.	Water	144-149	bone morphogenetic protein 7	Homo sapiens	189-193
16551066-1	2006	The electronic structure of hydrated H3O+ and OH- is probed in a water jet by photoelectron spectroscopy employing 100 eV photons.	Water	65-70	H3 clustered histone 15	Homo sapiens	37-48
32712253-4	2020	BDNF-PAMs were prepared by solid/oil/water emulsion of poly(L-lactide-co-glycolide) and nanoprecipitated BDNF and subsequent coating with fibronectin.	Water	37-42	brain-derived neurotrophic factor	Rattus norvegicus	0-4
16343773-0	2006	RANTES, MDC and SDF-1alpha, prevent the HIVgp120-induced food and water intake decrease in rats.	Water	66-71	C-C motif chemokine ligand 5	Rattus norvegicus	0-6
32972935-1	2020	Here, we report the complete genome sequence of Pseudomonas chilensis strain ABC1, which was isolated from a soil interstitial water sample collected at the University Adolfo Ibanez, Valparaiso, Chile.	Water	127-132	ATP binding cassette subfamily A member 1	Homo sapiens	77-81
16515860-0	2006	Low-resolution 1H spin-spin relaxation of n-decane/water emulsions stabilized by beta-casein.	Water	51-56	spindlin 1	Homo sapiens	18-22
16515860-0	2006	Low-resolution 1H spin-spin relaxation of n-decane/water emulsions stabilized by beta-casein.	Water	51-56	spindlin 1	Homo sapiens	23-27
33036527-8	2020	After c-myc silenced cells were treated with PM2.5 water soluble solution, The mRNA levels of c-myc, c-fos, and k-ras decreased by 84.1%, 45.4%, and 54.6% (P<0.05) , p53 increased by 192.9% (P<0.05) , and the expression of Caspase-3, Caspase-8, and Caspase-9 decreased by 24.4%, 36.1%, 60.9% (P<0.05) .	Water	51-56	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	101-106
16522119-6	2006	The addition of methanol and of hexafluoro-2-propanol to 1 in aprotic solvents models the PLP-water interaction in the enzymatic active site.	Water	94-99	proteolipid protein 1	Homo sapiens	90-93
33036527-8	2020	After c-myc silenced cells were treated with PM2.5 water soluble solution, The mRNA levels of c-myc, c-fos, and k-ras decreased by 84.1%, 45.4%, and 54.6% (P<0.05) , p53 increased by 192.9% (P<0.05) , and the expression of Caspase-3, Caspase-8, and Caspase-9 decreased by 24.4%, 36.1%, 60.9% (P<0.05) .	Water	51-56	KRAS proto-oncogene, GTPase	Homo sapiens	112-117
16509656-2	2006	From absorbed energies, a shock wave analysis, high-speed laser stroboscopy, and thermodynamic data of high-temperature water the enthalpy, temperature, density, pressure, and the reaction time window for the hot water filament could be characterized.	Water	120-125	alcohol dehydrogenase iron containing 1	Homo sapiens	209-212
32816482-2	2020	Here we introduce Raman difference with simultaneous curve fitting (RD-SCF) analysis to extract the OH-stretch spectrum of hydration shell water, not only for the fully hydrated ions (Mg2+, La3+ and Cl-) but also for the ion pairs.	Water	139-144	KIT ligand	Homo sapiens	71-74
16499402-8	2006	For the competitive epoxidation of cis- and trans-2-octenes, the ratio of the formation rate of cis-2,3-epoxyoctane to that of the trans isomer (R(cis)/R(trans)) is relatively high (21.3) in comparison with those observed for the tungstate catalysts, including [gamma-SiW10O34(H2O)2]4-.	Water	277-280	suppressor of cytokine signaling 2	Homo sapiens	96-101
32816482-3	2020	RD-SCF analyses of diluted MgCl2 (0.18 M) and LaCl3 (0.12 M) solutions relative to aqueous NaCl of equivalent Cl- concentrations provide the OH-stretch spectra of water in the hydration shells of fully hydrated Mg2+ and La3+ cations relative to that of Na+.	Water	163-168	KIT ligand	Homo sapiens	3-6
32816482-6	2020	The OH-stretch spectrum of the shared/intervening water in the SSIP, retrieved by second-round RD-SCF analysis (2RD-SCF), shows that the average H-bonding of the shared water is weaker than the hydration water of the fully hydrated cation (Mg2+ or La3+) but stronger than that of the anion (Cl-).	Water	50-55	KIT ligand	Homo sapiens	98-101
32816482-6	2020	The OH-stretch spectrum of the shared/intervening water in the SSIP, retrieved by second-round RD-SCF analysis (2RD-SCF), shows that the average H-bonding of the shared water is weaker than the hydration water of the fully hydrated cation (Mg2+ or La3+) but stronger than that of the anion (Cl-).	Water	50-55	KIT ligand	Homo sapiens	116-119
32816482-6	2020	The OH-stretch spectrum of the shared/intervening water in the SSIP, retrieved by second-round RD-SCF analysis (2RD-SCF), shows that the average H-bonding of the shared water is weaker than the hydration water of the fully hydrated cation (Mg2+ or La3+) but stronger than that of the anion (Cl-).	Water	169-174	KIT ligand	Homo sapiens	98-101
32816482-6	2020	The OH-stretch spectrum of the shared/intervening water in the SSIP, retrieved by second-round RD-SCF analysis (2RD-SCF), shows that the average H-bonding of the shared water is weaker than the hydration water of the fully hydrated cation (Mg2+ or La3+) but stronger than that of the anion (Cl-).	Water	169-174	KIT ligand	Homo sapiens	116-119
32816482-6	2020	The OH-stretch spectrum of the shared/intervening water in the SSIP, retrieved by second-round RD-SCF analysis (2RD-SCF), shows that the average H-bonding of the shared water is weaker than the hydration water of the fully hydrated cation (Mg2+ or La3+) but stronger than that of the anion (Cl-).	Water	169-174	KIT ligand	Homo sapiens	98-101
32816482-6	2020	The OH-stretch spectrum of the shared/intervening water in the SSIP, retrieved by second-round RD-SCF analysis (2RD-SCF), shows that the average H-bonding of the shared water is weaker than the hydration water of the fully hydrated cation (Mg2+ or La3+) but stronger than that of the anion (Cl-).	Water	169-174	KIT ligand	Homo sapiens	116-119
32940115-0	2021	Associations between Household Water Fluoridation Status and Plain Tap or Bottled Water Consumption.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	67-70
32930879-7	2021	The Ca2+-activated K+ channels of large and intermediate conductance, KCa3.1 and KCa1.1, and the volume-regulated anion channel, whose combined activity results in the extrusion of KCl and osmotic water, control cell volume, and in turn migration, invasion, and apoptotic cell death.	Water	197-202	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	81-87
16494413-1	2006	The inverse temperature transition (ITT) of a biomimetic model for elastin, capped GVG(VPGVG) in liquid water, is investigated by a comprehensive classical molecular dynamics study.	Water	104-109	elastin	Homo sapiens	67-74
32786553-3	2020	This study reports a polydopamine (PDA) intercalated TFNi nanofiltration membrane (PA-PSF2, PDA coating time at 2hr) that possessed nearly an order of magnitude higher water permeance of 14.8 +- 0.4 Lm-2h-1bar-1 compared to the control TFC membrane (PA-PFS0) of 2.4 +- 0.5 Lm-2h-1bar-1.	Water	168-173	GINS complex subunit 2	Homo sapiens	86-90
16497651-0	2006	Tap-water enema for children with myelomeningocele and neurogenic bowel dysfunction.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
16497651-1	2006	AIM: To evaluate the outcome of transrectal irrigation (TRI) using clean tap water without salt in children with myelomeningocele and neurogenic bowel problems.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
16497651-9	2006	CONCLUSION: Transrectal irrigation with tap water is a safe method to resolve constipation and faecal incontinence in children with myelomeningocele and neurogenic bowel dysfunction, but it does not help children to independence at the toilet.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
32458500-5	2020	The Rh-In catalyst can effectively catalyse methanol synthesis but inhibit reverse water-gas shift reaction under H 2 -deficient gas flow and shows the best competitive methanol productivity under industrially applicable conditions in comparison with the literature reported values.	Water	83-88	relaxin 2	Homo sapiens	114-117
16517632-10	2006	Furthermore, the community structure of the tap water did not change substantially for several months.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
33013877-6	2020	Further Treg-enrichment (~80%) of the AgX population indicated FoxP3+CD25hiCD4+ Treg played a key role in EAU-suppression while FoxP3-CD25lo/-CD4+ T cells did not.	Water	106-109	interleukin 2 receptor, alpha chain	Mus musculus	69-78
16637327-1	2006	An approach to determining the microscopic surface tension in water-protein matrix using EPR of spin label was developed.	Water	62-67	spindlin 1	Homo sapiens	96-100
16637327-3	2006	Changes in specific surface tension of spin-labeled molecules of serum albumin, hemoglobin, and antibodies were studied depending on protein concentration, the structure of the reporter group, ligand state of the protein, and the presence of salts, water-soluble polymers, and D2O.	Water	249-254	spindlin 1	Homo sapiens	39-43
33013877-6	2020	Further Treg-enrichment (~80%) of the AgX population indicated FoxP3+CD25hiCD4+ Treg played a key role in EAU-suppression while FoxP3-CD25lo/-CD4+ T cells did not.	Water	106-109	interleukin 2 receptor, alpha chain	Mus musculus	69-73
16315141-3	2006	The preferred conformation of PAMP was determined in a helix-inducing trifluoroethanol and water (TFE/H2O) solution, and in a membrane-mimetic sodium dodecylsulfate-d25 (SDS) micellar solution.	Water	91-96	adrenomedullin	Homo sapiens	30-34
16315141-3	2006	The preferred conformation of PAMP was determined in a helix-inducing trifluoroethanol and water (TFE/H2O) solution, and in a membrane-mimetic sodium dodecylsulfate-d25 (SDS) micellar solution.	Water	102-105	adrenomedullin	Homo sapiens	30-34
33013877-6	2020	Further Treg-enrichment (~80%) of the AgX population indicated FoxP3+CD25hiCD4+ Treg played a key role in EAU-suppression while FoxP3-CD25lo/-CD4+ T cells did not.	Water	106-109	CD4 antigen	Mus musculus	75-78
32983166-1	2020	Background and Purpose: The mechanism underlying the pathology of neuromyelitis optica spectrum disorders (NMOSD) remains unclear even though antibodies to the water channel protein aquaporin-4 (AQP4) on astrocytes play important roles.	Water	160-165	aquaporin 4	Homo sapiens	182-193
23105572-7	2006	Mean arsenic level detected in samples collected from tap water supply was 0.013 ppm (Range 0-0.0430 ppm, Standard Deviation 0.00911 and Standard error of Mean 0.000515).	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
23105572-9	2006	The mean arsenic level detected in water samples of booster pumping station was within WHO/EPA permissible limit while mean arsenic level detected in tap water samples was marginally higher.	Water	154-159	nuclear RNA export factor 1	Homo sapiens	150-153
23105572-10	2006	Mixing of ground water and contamination through broken or leaking channel could be the possible reason of higher arsenic level in tap water.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	131-134
23105572-10	2006	Mixing of ground water and contamination through broken or leaking channel could be the possible reason of higher arsenic level in tap water.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	131-134
32983166-1	2020	Background and Purpose: The mechanism underlying the pathology of neuromyelitis optica spectrum disorders (NMOSD) remains unclear even though antibodies to the water channel protein aquaporin-4 (AQP4) on astrocytes play important roles.	Water	160-165	aquaporin 4	Homo sapiens	195-199
33911351-8	2020	About 40 ml of tap water was collected in each chamber.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
16194574-7	2006	Tap water recoveries averaged 32% for new filters, 30% for filters used twice, and 38% for filters used three times.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
33612779-12	2020	In this study, we found that P. aeruginosa strains recovered from city water systems must be considered potential reservoir for ESBL genes, especially blaKPC-2 and blaVIM-2.	Water	71-76	KPC-2	Pseudomonas aeruginosa	151-159
16546977-10	2006	Thus, the study shows that water-soluble inhibitors of thioredoxin reductase-1, such as PX-916, can block thioredoxin-1 signaling in tumors producing marked inhibition of tumor growth.	Water	27-32	thioredoxin reductase 1	Homo sapiens	55-78
16550958-0	2006	Non-invasive treatment of intractable posterior epistaxis with hot-water irrigation.	Water	67-72	alcohol dehydrogenase iron containing 1	Homo sapiens	63-66
17318683-3	2007	The first substance was a 10-ml solution of tap water with 0.5% xanthan with a viscosity of 4500 mPa s, comparable to a yogurt drink.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
17318683-5	2007	Tap water was used as the control substance.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
17318683-6	2007	Mean pharyngeal residue after swallowing tap water was 2.3% (SD = 1.2) of the initial volume in the oral cavity.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
33612779-12	2020	In this study, we found that P. aeruginosa strains recovered from city water systems must be considered potential reservoir for ESBL genes, especially blaKPC-2 and blaVIM-2.	Water	71-76	VIM-2	Pseudomonas aeruginosa	164-172
32846948-7	2020	Meanwhile, serum osmolality and concentrations of albumin, total protein, urea-N, glucose, and non-esterified fatty acids were increased (p < 0.05) with the increasing levels of water restriction.	Water	178-183	albumin	Ovis aries	50-57
16670711-8	2007	Non-Hispanic white women drank 0.4 (95% confidence interval (CI) 0.2; 0.7) liters more cold tap water per day than Hispanic women and 0.3 (95% CI 0.1; 0.4) liters more than non-Hispanic black women.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
16670711-9	2007	Non-Hispanic white women also reported drinking a higher proportion of filtered tap water, whereas Hispanic women replaced more of their tap water with bottled water.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	137-140
16670711-9	2007	Non-Hispanic white women also reported drinking a higher proportion of filtered tap water, whereas Hispanic women replaced more of their tap water with bottled water.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	137-140
16516263-9	2006	Finally, the results of discriminant function analysis showed that in rural households, garden size, greenhouse size, and garden watering times per month with tap treated water are associated with water consumption.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	159-162
16516263-9	2006	Finally, the results of discriminant function analysis showed that in rural households, garden size, greenhouse size, and garden watering times per month with tap treated water are associated with water consumption.	Water	171-176	nuclear RNA export factor 1	Homo sapiens	159-162
16321490-5	2006	Further evaluation of both HPC grades indicated that the cloud point values for Klucel-EF and HPC-L in water were 39(+/- 1) and 48 degrees C, respectively.	Water	103-108	2-hydroxyacyl-CoA lyase 1	Homo sapiens	94-99
32829391-0	2021	Tap Water Avoidance Decreases Rates of Hospital-Onset Pulmonary Nontuberculous Mycobacteria - a call for water Management in Healthcare.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
16435856-2	2006	Reaction of propargyl acetate with water catalyzed by Hg(OTf)2 afforded vinyl ketone as the major product along with a dimeric vinyl mercuric product and normal hydration products in small amounts.	Water	35-40	POU class 2 homeobox 2	Homo sapiens	57-62
16905347-1	2007	Melittin is a well-known water-soluble toxic peptide present in bee venom of Apis mellifera, capable of interacting with and disrupting cell membranes thus producing many effects on living cells.	Water	25-30	melittin	Apis mellifera	0-8
32829391-0	2021	Tap Water Avoidance Decreases Rates of Hospital-Onset Pulmonary Nontuberculous Mycobacteria - a call for water Management in Healthcare.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	0-3
32830348-2	2020	Aquaporin-4 (AQP4) can effectively promote the diffusion of water across cellular membranes.	Water	60-65	aquaporin 4	Homo sapiens	0-11
16438523-3	2006	Several individual steps (reduction and hydrolysis, water elimination, ether cleavage, and oxidation) of the proposed reaction cascade calculated at the PCM-MP2/6-31G(d)//B3LYP/6-31G(d) level of theory are presented and discussed.	Water	52-57	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	173-176
32830348-2	2020	Aquaporin-4 (AQP4) can effectively promote the diffusion of water across cellular membranes.	Water	60-65	aquaporin 4	Homo sapiens	13-17
17402285-0	2007	Unsafe tap water in households supplied from groundwater in the Salento Region of Southern Italy.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
32692174-2	2020	Here, an external fluorine anion-free direct deoxyhydrotrifluoromethylation of alpha-keto esters with a difluoromethylating reagent has been achieved in which the employment of water can promote the dissociation of CF2 group to form CF3 moiety, which provides the successful transformation.	Water	177-182	ATPase H+ transporting accessory protein 1	Homo sapiens	215-218
17402289-1	2007	The consumption of bottled and plastic-bagged drinking water in Tanzania has increased largely because of the deteriorating quality of tap water.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	135-138
17402289-8	2007	Microbiological quality of tap water was found to be worse compared with bottled water, with 49.2% and 26.2% of sampling points showing the presence of total coliform and faecal coliform organisms, respectively.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
17360692-8	2007	These findings reveal the existence of a gender-influenced molecular mechanism involving AQP5 that allows transcellular and paracellular routes of water transport to act in conjunction.	Water	147-152	aquaporin 5	Mus musculus	89-93
16322051-2	2006	The relation between substrate and water transport was studied in Na+-coupled cotransporters of glucose (SGLT1) and of iodide (NIS) expressed in Xenopus oocytes.	Water	35-40	solute carrier family 5 (sodium/glucose cotransporter), member 1, gene 2 L homeolog	Xenopus laevis	105-110
16427351-1	2006	The vibrational characteristics (vibrational frequencies, infrared intensities and Raman activities) for the hydrogen-bonded system of Vitamin C (L-ascorbic acid) with five water molecules have been predicted using ab initio SCF/6-31G(d,p) calculations and DFT (BLYP) calculations with 6-31G(d,p) and 6-31++G(d,p) basis sets.	Water	173-178	KIT ligand	Homo sapiens	225-228
16293618-7	2006	These results indicate that Shank2 is a novel NHE3 interacting protein that is involved in the fine regulation of transepithelial salt and water transport through affecting NHE3 expression and activity.	Water	139-144	solute carrier family 9 member A3	Homo sapiens	46-50
16293618-7	2006	These results indicate that Shank2 is a novel NHE3 interacting protein that is involved in the fine regulation of transepithelial salt and water transport through affecting NHE3 expression and activity.	Water	139-144	solute carrier family 9 member A3	Homo sapiens	173-177
17204273-6	2007	The method was validated at levels of 0.25, 1.0, and 5.0 microg/L in the tap water and river water samples, and accuracy was achieved in the range of 94-109%.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
32661130-5	2020	We demonstrate for the first time that UT-A2 and UT-A3 can transport water, and we confirm that UT-B is permeable to water.	Water	69-74	solute carrier family 14 (urea transporter), member 2	Mus musculus	49-54
16408926-1	2006	The method presented here provides a direct way to determine mercury in tap water samples at the parts-per-trillion level.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
32602485-4	2020	Due to the synergism of boronate affinity and the molecular imprinting effect, the resultant B-FMIP NPs demonstrated specific recognition and remarkable selectivity toward the template glycoprotein (ovalbumin, OVA) with a high imprinted factor (alpha) of 6.0 and gave rise to obvious fluorescence quenching after binding with OVA in water.	Water	333-338	THO complex 5	Homo sapiens	95-99
16372105-1	2006	The exchange rates of the amido-protons of uracil with water were determined by NMR diffusion experiments and the results showed a factor 2 difference in lability between them, which was confirmed by more classical 2D-NMR exchange experiments.	Water	55-60	transcription termination factor 2	Homo sapiens	131-139
16671491-0	2006	Increased seizure duration in mice lacking aquaporin-4 water channels.	Water	55-60	aquaporin 4	Mus musculus	43-54
17302489-12	2007	They apply the present method to "solute" water and formaldehyde in aqueous solvent using the simple point charge model, and the results are compared with those from other methods: the six-dimensional molecular Ornstein-Zernike SCF, the one-dimensional site-site RISM-SCF, and the polarizable continuum model.	Water	42-47	KIT ligand	Homo sapiens	228-231
17257042-6	2007	On the contrary, K2(suc) and K2(dmmal) yielded preferentially the dinuclear species [fac-Ru(DMSO-S)3(H2O)(mu-dicarb)]2 (dicarb = dmmal, 11; suc, 13), with two bridging dicarboxylate moieties.	Water	101-104	RBPJ pseudogene 3	Homo sapiens	20-23
32782018-2	2020	Aquaporin-4 immunoglobulin G (AQP4-IgG) autoantibodies, which target the water channel aquaporin-4 (AQP4) on astrocytic membrane, are pathogenic in NMOSD.	Water	73-78	aquaporin 4	Mus musculus	30-34
17180336-8	2007	Application of the electrodes to determine perchlorate in tap water and human urine is also reported.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
16671491-6	2006	These results implicate AQP4 in water and potassium regulation associated with neuronal activity and seizures.	Water	32-37	aquaporin 4	Mus musculus	24-28
16500886-10	2006	The water extracts of rosemary, rosemary LA had the highest ACE inhibitory activity (90.5%), followed by lemon balm (81.9%) and oregano (37.4 %).	Water	4-9	angiotensin-converting enzyme	Oryctolagus cuniculus	60-63
32782018-2	2020	Aquaporin-4 immunoglobulin G (AQP4-IgG) autoantibodies, which target the water channel aquaporin-4 (AQP4) on astrocytic membrane, are pathogenic in NMOSD.	Water	73-78	aquaporin 4	Mus musculus	100-104
32785060-4	2020	Pervaporation experiments were carried out at temperatures of 40, 50, 60 and 70  C. When the feed comprised pure water and ethanol, a much higher flux of water than ethanol was observed at all temperatures through GO films stabilized by the two crosslinkers (humic acid, GO-HAL, and the synthetic hyperbranched polyol, GO-HBPO), indicating the separation ability of these crosslinked membranes.	Water	113-118	histidine ammonia-lyase	Homo sapiens	274-277
16521550-0	2006	[Studies of interactions of carbonic anhydrase B with water and urea: II.	Water	54-59	carbonic anhydrase 2	Homo sapiens	28-48
17027755-0	2007	Differential effects of water deprivation and rehydration on Fos and FosB/DeltaFosB staining in the rat brainstem.	Water	24-29	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-73
17027755-1	2007	This study examined the effects of dehydration and rehydration with water on Fos and FosB staining in the brainstem of rats.	Water	68-73	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	77-80
32785060-4	2020	Pervaporation experiments were carried out at temperatures of 40, 50, 60 and 70  C. When the feed comprised pure water and ethanol, a much higher flux of water than ethanol was observed at all temperatures through GO films stabilized by the two crosslinkers (humic acid, GO-HAL, and the synthetic hyperbranched polyol, GO-HBPO), indicating the separation ability of these crosslinked membranes.	Water	154-159	histidine ammonia-lyase	Homo sapiens	274-277
17027755-1	2007	This study examined the effects of dehydration and rehydration with water on Fos and FosB staining in the brainstem of rats.	Water	68-73	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	85-89
32785060-5	2020	For feed mixtures of water and ethanol, the GO-HAL and GO-HBPO membranes showed good separation performances by producing permeates with a significantly higher water content than the feed at all temperatures.	Water	21-26	histidine ammonia-lyase	Homo sapiens	47-50
16685599-5	2006	U937-ecoR monocytic cells expressing increased levels of TRPM2 also exhibited significantly increased [Ca(2+)](i) and increased apoptosis after treatment with H(2)O(2) or TNFalpha.	Water	159-164	transient receptor potential cation channel subfamily M member 2	Homo sapiens	57-62
32785060-5	2020	For feed mixtures of water and ethanol, the GO-HAL and GO-HBPO membranes showed good separation performances by producing permeates with a significantly higher water content than the feed at all temperatures.	Water	160-165	histidine ammonia-lyase	Homo sapiens	47-50
32831847-12	2020	These findings not only indicate the presence of antibiotic-resistant virulent Vibrio species from dam, borehole, and tap water samples that could pose a health risk to humans who either come in contact with or consume water but also present these lytic phages as alternative agents that can be exploited for biological control of these pathogenic strains.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
16257493-1	2006	Aquaporin-4 water channels and the inwardly rectifying potassium channels Kir4.1 are coexpressed in a highly polarized manner at the perivascular and subvitreal endfeet of retinal Muller cells and astrocytes.	Water	12-17	aquaporin 4	Mus musculus	0-11
17377749-3	2007	They had used a contact lens care system irregularly with tap water.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
17377749-7	2007	Careful contact lens management is needed and tap-water rinsing should be eliminated from the lens care regimen.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
17131426-3	2007	Here we investigated the effects of water deprivation on neuronal nitric oxide synthase (nNOS) expression within the rat amygdala; a brain area involved in modulating ingestive behavior and autonomic function.	Water	36-41	nitric oxide synthase 1	Rattus norvegicus	57-87
17131426-3	2007	Here we investigated the effects of water deprivation on neuronal nitric oxide synthase (nNOS) expression within the rat amygdala; a brain area involved in modulating ingestive behavior and autonomic function.	Water	36-41	nitric oxide synthase 1	Rattus norvegicus	89-93
17131426-4	2007	Water deprivation resulted in significant increases in nNOS immunoreactivity (-ir) within different regions of the amygdala compared with euhydrated rats.	Water	0-5	nitric oxide synthase 1	Rattus norvegicus	55-59
17214471-2	2007	The Morokuma decomposition scheme of ab initio interaction energies at the SCF level and the dispersion component at MP2 level were used to reproduce the molecular parameters of the solute-water interaction potential.	Water	189-194	KIT ligand	Homo sapiens	75-78
17071654-1	2007	Small molecule rescue of mutant forms of human carbonic anhydrase II (HCA II) occurs by participation of exogenous donors/acceptors in the proton transfer pathway between the zinc-bound water and solution.	Water	186-191	carbonic anhydrase 2	Homo sapiens	47-68
17123747-1	2007	The xenobiotic-activated nuclear receptors PXR (pregnane X receptor) and CAR (constitutive androstane receptor) and the vitamin D(3)-activated nuclear receptor VDR regulate steroid and xenobiotic metabolism by inducing the phase I cytochrome P450 monooxygenases, phase II conjugating transferases, and the phase III transporters, which mediate the efflux of water-soluble lipid metabolites from cells.	Water	358-363	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	160-163
17441143-3	2007	The formation of a hydrogen-bonding network between the triazolate moieties and sulfonate ions, bridged by water molecules, was found to play an important role in the spin-crossover event.	Water	107-112	spindlin 1	Homo sapiens	167-171
16971495-1	2007	Glucocorticoids stimulate the intestinal absorption of Na(+) and water partly by regulation of the Na(+)/H(+) exchanger 3 (NHE3).	Water	65-70	solute carrier family 9 member A3	Homo sapiens	99-121
16971495-1	2007	Glucocorticoids stimulate the intestinal absorption of Na(+) and water partly by regulation of the Na(+)/H(+) exchanger 3 (NHE3).	Water	65-70	solute carrier family 9 member A3	Homo sapiens	123-127
16895520-1	2007	BACKGROUND INFORMATION: AQP4 (aquaporin 4) internalization and a concomitant decrease in the osmotic water permeability coefficient (Pf) after histamine exposure has been reported in AQP4-transfected gastric HGT1 cells.	Water	101-106	aquaporin 4	Homo sapiens	30-41
16895520-1	2007	BACKGROUND INFORMATION: AQP4 (aquaporin 4) internalization and a concomitant decrease in the osmotic water permeability coefficient (Pf) after histamine exposure has been reported in AQP4-transfected gastric HGT1 cells.	Water	101-106	aquaporin 4	Homo sapiens	183-187
17854102-4	2007	Photophysical properties of the ligand and of the EuL3 and TbL3 complexes have been determined for both microcrystalline samples and solutions in water and acetonitrile.	Water	146-151	transducin beta like 3	Homo sapiens	59-63
17143065-1	2007	PURPOSE OF REVIEW: Guanylin peptides are secreted from the intestine and influence electrolyte and water transport in intestine and kidney, suggesting that these peptides act as intestinal natriuretic peptides.	Water	99-104	guanylate cyclase activator 2a (guanylin)	Mus musculus	19-27
17135396-0	2007	Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.	Water	127-132	phosphodiesterase 4D	Homo sapiens	52-72
17135396-8	2007	Here PDE4D is activated through PKA phosphorylation and reduces the osmotic water permeability.	Water	76-81	phosphodiesterase 4D	Homo sapiens	5-10
17915698-9	2007	It was proposed that PFCAs initially are decarboxylated by 185 nm light, and the radical thus formed reacts with water to form shorter-chain PFCA with one less CF2 unit.	Water	113-118	ATPase H+ transporting accessory protein 1	Homo sapiens	160-163
17504749-1	2007	A compact and transportable water calorimeter has been developed and extensively tested in the intensive, collimated neutron field of the PTB.	Water	28-33	polypyrimidine tract binding protein 1	Homo sapiens	138-141
17097063-6	2006	Taken together, our data indicate that atRA increases AQP5 expression through transactivation of Sp1, leading to an increase in plasma membrane water permeability.	Water	144-149	aquaporin 5	Mus musculus	54-58
17097614-7	2006	Taken together, these findings suggest that GPx-1 inhibits UVA-induced AP-2alpha expression by suppressing the accumulation of H(2)O(2).	Water	127-132	glutathione peroxidase 1	Homo sapiens	44-49
17097614-7	2006	Taken together, these findings suggest that GPx-1 inhibits UVA-induced AP-2alpha expression by suppressing the accumulation of H(2)O(2).	Water	127-132	transcription factor AP-2 alpha	Homo sapiens	71-80
17177430-0	2006	Hsc70 ATPase: an insight into water dissociation and joint catalytic role of K+ and Mg2+ metal cations in the hydrolysis reaction.	Water	30-35	heat shock protein family A (Hsp70) member 8	Bos taurus	0-12
17177430-1	2006	Hybrid quantum mechanics/molecular mechanics simulations, coupled to the recently introduced metadynamics method, performed on the adenosine triphosphate (ATP) of the bovine Hsc70 ATPase protein, show which specific water molecule of the solvation shell of the Mg2+ metal cation acts as a trigger in the initial phase of the ATP hydrolysis reaction in ATP synthase.	Water	216-221	heat shock protein family A (Hsp70) member 8	Bos taurus	174-186
17117089-0	2006	Focal F-18 FDG uptake mimicking malignant gastric localizations disappearing after water ingestion on PET/CT images.	Water	83-88	mastermind like domain containing 1	Homo sapiens	6-10
17304849-1	2006	PBS, a new kind of biodegradable polymers (BDPs), can be used as carbon source and biofilm carrier to remove nitrate from drinking water source.	Water	131-136	translocator protein	Homo sapiens	0-3
17405260-11	2006	Survival time was also significantly decreased in the animals infused with ethanol (81 +/- 60 minutes) compared with those infused with tap water (130 +/- 51 minutes; p = 0.035).	Water	140-145	putative ABC-transporter	Sus scrofa	136-139
17174662-3	2006	PURPOSE: The purpose of this study was to compare the setting behavior of irreversible hydrocolloid impression materials when mixed with tap and distilled water, and to determine the impact of typical cations present in tap water and their concentrations on the setting process.	Water	224-229	nuclear RNA export factor 1	Homo sapiens	220-223
17174662-9	2006	RESULTS: Statistical analysis showed significant (P&lt;.001) acceleration in the setting rate for Kromopan 100, the working time of which was shorter with tap water by 23.4 seconds and the setting time, by 32.8 seconds.	Water	159-164	nuclear RNA export factor 1	Homo sapiens	155-158
17174662-11	2006	At the same time, the rigidity of the set impression materials mixed with tap water increased by approximately 10%.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
17174662-12	2006	With Ypeen Premium, the setting time decreased significantly by 20.0 seconds (P&lt;.001) with tap water, while the working time and rigidity did not change.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
17174662-15	2006	CONCLUSION: Setting of irreversible hydrocolloid impression materials can be significantly accelerated when tap water with high water hardness is used for mixing or when the mixing water contains higher concentrations of cations such as Na(+), Ca(2+), and Al(3+).	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
17174662-15	2006	CONCLUSION: Setting of irreversible hydrocolloid impression materials can be significantly accelerated when tap water with high water hardness is used for mixing or when the mixing water contains higher concentrations of cations such as Na(+), Ca(2+), and Al(3+).	Water	128-133	nuclear RNA export factor 1	Homo sapiens	108-111
17174662-15	2006	CONCLUSION: Setting of irreversible hydrocolloid impression materials can be significantly accelerated when tap water with high water hardness is used for mixing or when the mixing water contains higher concentrations of cations such as Na(+), Ca(2+), and Al(3+).	Water	128-133	nuclear RNA export factor 1	Homo sapiens	108-111
16903001-0	2006	Ab initio QM/MM dynamics of H3O+ in water.	Water	36-41	H3 clustered histone 15	Homo sapiens	28-31
16903001-1	2006	A molecular dynamics (MD) simulation based on a combined ab initio quantum mechanics/molecular mechanics (QM/MM) method has been performed to investigate the solvation structure and dynamics of H3O+ in water.	Water	202-207	H3 clustered histone 15	Homo sapiens	194-197
16903001-6	2006	Besides the three nearest-neighbor water molecules directly hydrogen-bonded to H3O+, other neighbor waters, such as a fourth water molecule which interacts preferentially with the oxygen atom of the hydronium ion, are found occasionally near the ion.	Water	35-40	H3 clustered histone 15	Homo sapiens	79-82
17091438-7	2006	2000 ml of tap water.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
17059987-3	2006	We report a patient who developed acute renal failure, acute hepatic failure, autoimmune hemolytic anemia, and thrombocytopenia after oral intake of hot-water extract of Cupressus funebris Endl (Mourning Cypress), which is rich in flavonoids.	Water	153-158	alcohol dehydrogenase iron containing 1	Homo sapiens	149-152
17217173-7	2006	The method has been successfully applied for determination of trace amounts of thiocyanate in tap water, saliva sample and a synthetic mixture.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
16487958-6	2006	Household tap water arsenic levels in Ajo (20.3+/-3.7 microg/L) were higher than in those Tucson (4.0+/-2.3 microg/L), as were mean urinary total inorganic arsenic levels (29.1+/-20.4 and 11.0+/-12.0 microg/L, respectively).	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
27718711-1	2006	The valves set bath tap water temperature to a maximum of 48 C. The ECA steering committee has submitted the subject of Ms Creagh"s Hot Water Burns Like Fire campaign as a matter for discussion at RCN congress, next April.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
17016661-3	2006	Because, a marginal enhancement of this protein may be adequate for genomic protection, we studied alterations in MGMT activity and expression in human peripheral blood lymphocytes and cancer cell lines induced by water-soluble and alcohol-soluble constituents of several plants with established antioxidant and medicinal properties.	Water	214-219	O-6-methylguanine-DNA methyltransferase	Homo sapiens	114-118
16649172-5	2006	The BFP was dissolved in double-deionized water, and was prepared at different concentrations.	Water	42-47	ring finger protein 112	Homo sapiens	4-7
17269337-3	2006	The water-soluble P concentration in the culture media inoculated with OP1 , OP2 and NOP3 increased 38.53, 64.53 and 54.06 fold, respectively, compared with the control.	Water	4-9	bone morphogenetic protein 7	Homo sapiens	71-74
17543221-5	2006	On the other hand the group of Gheorghe Benga has reported a decreased water permeability of RBC in patients with Duchenne muscular dystrophy.	Water	71-76	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	93-96
17543222-1	2006	Aquaporin-1 (AQP1) is a water channel protein mainly expressed in endothelial and epithelial cells of many tissues, including the vasculature where it serves to increase cell membrane water permeability.	Water	24-29	aquaporin 1	Gallus gallus	0-11
17543222-1	2006	Aquaporin-1 (AQP1) is a water channel protein mainly expressed in endothelial and epithelial cells of many tissues, including the vasculature where it serves to increase cell membrane water permeability.	Water	24-29	aquaporin 1	Gallus gallus	13-17
17543222-1	2006	Aquaporin-1 (AQP1) is a water channel protein mainly expressed in endothelial and epithelial cells of many tissues, including the vasculature where it serves to increase cell membrane water permeability.	Water	184-189	aquaporin 1	Gallus gallus	0-11
17543222-1	2006	Aquaporin-1 (AQP1) is a water channel protein mainly expressed in endothelial and epithelial cells of many tissues, including the vasculature where it serves to increase cell membrane water permeability.	Water	184-189	aquaporin 1	Gallus gallus	13-17
17044712-4	2006	Fully functional lipid-modified N-Ras protein was obtained by chemical-biological synthesis ligating the expressed water soluble N-terminus with a chemically synthesized (2)H or (13)C labeled lipidated heptapeptide.	Water	115-120	NRAS proto-oncogene, GTPase	Homo sapiens	32-37
16829118-0	2006	Spectroscopic studies into the influence of UV radiation on elastin hydrolysates in water solution.	Water	84-89	elastin	Homo sapiens	60-67
16829118-1	2006	An investigation into the influence of UV irradiation on elastin hydrolysates dissolved in water was carried out using UV-Vis spectroscopy and spectrofluorometry.	Water	91-96	elastin	Homo sapiens	57-64
17007115-3	2006	FGD cannot remove Hg0, but easily removes Hg2+ because of its solubility in water.	Water	76-81	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	42-45
16966806-5	2006	With the high sensitivity of the method, Pb(II), Cu(II) and Fe(III) in tap water were successfully determined, and the recoveries were 99 - 105%.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
16966806-6	2006	The concentrations of these metal ions found in tap water did not exceed the maximum allowed concentrations regulated by the U.S. Environmental Protection Agency.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
16840540-4	2006	The mineralized water was designed to mimic the composition of a typical tap water.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
16922539-4	2006	The water solubility of cucurbit[8]uril is enhanced by inclusion of water soluble cinnamic acids and positions the olefins in an arrangement that favors the formation of syn head-head cyclobutanes in near quantitative yields.	Water	4-9	synemin	Homo sapiens	170-173
16865175-2	2006	Two models have been tested that start from the outer sphere complexes, (H2O)[U(A)O2F(OH2)4+]...[U(B)O2(OH2)5(2+)] and [U(A)O2F(OH2)4+]...[U(B)O2(OH2)5(2+)]; the geometry and energies of the intermediates and transition states along possible reaction pathways have been calculated using different ab initio methods, SCF, B3LYP and MP2.	Water	73-76	KIT ligand	Homo sapiens	316-319
16564496-2	2006	Phenotype analysis of transgenic mice lacking AQP4 has provided compelling evidence for involvement of AQP4 in cerebral water balance, astrocyte migration, and neural signal transduction.	Water	120-125	aquaporin 4	Mus musculus	46-50
16564496-2	2006	Phenotype analysis of transgenic mice lacking AQP4 has provided compelling evidence for involvement of AQP4 in cerebral water balance, astrocyte migration, and neural signal transduction.	Water	120-125	aquaporin 4	Mus musculus	103-107
16564496-3	2006	AQP4-null mice have reduced brain swelling and improved neurological outcome in models of (cellular) cytotoxic cerebral edema including water intoxication, focal cerebral ischemia, and bacterial meningitis.	Water	136-141	aquaporin 4	Mus musculus	0-4
16564496-4	2006	However, brain swelling and clinical outcome are worse in AQP4-null mice in models of vasogenic (fluid leak) edema including cortical freeze-injury, brain tumor, brain abscess and hydrocephalus, probably due to impaired AQP4-dependent brain water clearance.	Water	241-246	aquaporin 4	Mus musculus	58-62
16785752-7	2006	CONCLUSION: Immediate copious irrigation with tap water reduced the severity in alkali burns of the eye and shortened the healing time.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
16084007-0	2005	Spin-dependent absorption of water molecules.	Water	29-34	spindlin 1	Homo sapiens	0-4
16084007-1	2005	The effects of spin state of water molecules on its absorption on lyophilized DNA, lysozyme and some inorganic sorbents were studied.	Water	29-34	spindlin 1	Homo sapiens	15-19
16084007-4	2005	Clear-cut distinction in the sorption kinetics is determined by the difference in quantum statistics for spin isomers, which in its turn can give rise to remarkable differences in physico-chemical properties of ortho and para water.	Water	226-231	spindlin 1	Homo sapiens	105-109
16084007-5	2005	This finding opens a wide field of activity in studying fundamental and applied problems relating to the role of the spin state of water molecules in physics, chemistry, biology and medicine.	Water	131-136	spindlin 1	Homo sapiens	117-121
16154329-3	2005	2D-QSAR modeling using simulated annealing partial least squares (SA-PLS) method identified octanol/water partition coefficient, hydrophobicity, and negative charge as three important factors for MTX and MTX analogue affinity to rMrp2.	Water	100-105	ATP binding cassette subfamily C member 2	Rattus norvegicus	229-234
16263905-6	2005	When sequential pectin extraction of calli cell walls was performed, qua1-1 water-soluble and chelator-soluble extracts contained more arabinose and less uronic acid than wt.	Water	76-81	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	69-75
16355843-3	2005	Samples from the MAP2 group had fewer spoilage bacteria, stable red color (no change of a* value), and good physical attributes (high water-holding capacity, little loss from cooking, and low shear force needed for cutting) compared with samples from other treatment groups.	Water	134-139	microtubule associated protein 2	Homo sapiens	17-21
16506635-3	2005	When these agents are ineffective or the side effects too bothersome, patients often resort to palliative care, for example, with tap water, saline, bicarbonate solutions, mouthwashes, or saliva substitutes.	Water	134-139	nuclear RNA export factor 1	Homo sapiens	130-133
16277531-1	2005	Improved 1H ENDOR data from the S(EPR1) intermediate formed during turnover of the nitrogenase alpha-195Gln MoFe protein with C2(1,2)H2 in (1,2)H2O buffers, taken in context with the recent study of the intermediate formed from propargyl alcohol, indicate that S(EPR1) is a product complex, likely with C2H4 bound as a ferracycle to a single Fe of the FeMo-cofactor active site.	Water	144-147	baculoviral IAP repeat containing 5	Homo sapiens	34-38
18970287-11	2005	Application of the method to tap water and two different river water samples resulted in values well confirmed by direct determinations with ET-AAS.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
16262394-4	2005	While syn-adduct was obtained in the reaction of 1 with water, anti-addition of chlorine atoms across the Si=Si double bond in 1 was observed in the reaction with carbon tetrachloride.	Water	56-61	synemin	Homo sapiens	6-9
16107506-1	2005	Aquaporin-5 (AQP5), an apical plasma membrane (APM) water channel in salivary glands, lacrimal glands, and airway epithelium, has an important role in fluid secretion.	Water	52-57	aquaporin 5	Rattus norvegicus	0-11
16107506-1	2005	Aquaporin-5 (AQP5), an apical plasma membrane (APM) water channel in salivary glands, lacrimal glands, and airway epithelium, has an important role in fluid secretion.	Water	52-57	aquaporin 5	Rattus norvegicus	13-17
16255571-11	2005	Pure water could be used as the spray solution for DESI, and it showed ionization efficiencies for RDX in the negative ion mode similar to that given by methanol/water.	Water	5-10	radixin	Homo sapiens	99-102
16276035-0	2005	Reduction of atherosclerosis in cholesterol-fed rabbits and decrease of expressions of intracellular adhesion molecule-1 and vascular endothelial growth factor in foam cells by a water-soluble fraction of Polygonum multiflorum.	Water	179-184	vascular endothelial growth factor A	Oryctolagus cuniculus	125-159
16193149-0	2005	Synthesis and structure of the framework scandium methylphosphonates ScF(H2O)CH3PO3 and NaSc(CH3PO3)2.0.5H2O.	Water	73-76	KIT ligand	Homo sapiens	69-72
16204884-5	2005	Ten structurally conserved water molecules are identified in each blade of the Kelch beta-propeller.	Water	27-32	kelch like family member 2	Homo sapiens	79-84
16051493-6	2005	Conversely, the recently introduced Kodak EDR2 showed an energy dependence for electron beams, the percentage depth-dose curve shifting towards the surface for 12 and 14 MeV electron beams compared to that in water.	Water	209-214	polyhomeotic homolog 2	Homo sapiens	42-46
16236866-9	2005	We suggest that nonsterile tap water is probably a safe alternative.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
16103109-1	2005	Aquaporin-4 (AQP4), the main water channel in the brain, is expressed in the perivascular membranes of mouse, rat, and human astrocytes.	Water	29-34	aquaporin 4	Mus musculus	0-11
16103109-1	2005	Aquaporin-4 (AQP4), the main water channel in the brain, is expressed in the perivascular membranes of mouse, rat, and human astrocytes.	Water	29-34	aquaporin 4	Mus musculus	13-17
16103109-11	2005	Moreover, even though AQP4 KD in mouse astrocytes did not result in a dramatic morphological phenotype, it induced a remarkable rearrangement of F-actin, not related to disruption of the dystrophin complex, indicating a primary role of this water channel in the cytoskeleton changes observed.	Water	241-246	aquaporin 4	Mus musculus	22-26
16353962-9	2005	Testing formulations with different concentrations of lactose by water vapor sorption indicated that CNK-20402 concentrations as low as 10% (wt/wt) could inhibit the recrystallization of lactose.	Water	65-70	connector enhancer of kinase suppressor of Ras 1	Homo sapiens	101-104
16353962-11	2005	The protective mechanism of lactose on the CNK-20402, based on water vapor sorption studies, is believed to be a result of (1) the drug-lactose interaction, and (2) competition between lactose and drug for the residual water in the formulation.	Water	63-68	connector enhancer of kinase suppressor of Ras 1	Homo sapiens	43-46
16353962-11	2005	The protective mechanism of lactose on the CNK-20402, based on water vapor sorption studies, is believed to be a result of (1) the drug-lactose interaction, and (2) competition between lactose and drug for the residual water in the formulation.	Water	219-224	connector enhancer of kinase suppressor of Ras 1	Homo sapiens	43-46
16052497-0	2005	Water deprivation increases the expression of neuronal nitric oxide synthase (nNOS) but not orexin-A in the lateral hypothalamic area of the rat.	Water	0-5	nitric oxide synthase 1	Rattus norvegicus	46-76
16052497-0	2005	Water deprivation increases the expression of neuronal nitric oxide synthase (nNOS) but not orexin-A in the lateral hypothalamic area of the rat.	Water	0-5	nitric oxide synthase 1	Rattus norvegicus	78-82
16052497-3	2005	In light of this, and the mounting evidence suggesting a role for nitric oxide in osmotic regulation within the hypothalamus, this study sought to determine the effects of 24- and 72-hours of water deprivation on nNOS protein expression within the LHA of the rat with immunohistochemistry.	Water	192-197	nitric oxide synthase 1	Rattus norvegicus	213-217
16052497-6	2005	Seventy-two hours of water deprivation lead to further increases in nNOS-like immunoreactivity at different levels of the LHA.	Water	21-26	nitric oxide synthase 1	Rattus norvegicus	68-72
16100044-8	2005	Aortic smooth muscle tissues from methimazole-induced hypothyroid rats (400 mg/L drinking water; 4 weeks) also showed a 68% decrease in the MGP mRNA level, as well as a 33% increase in calcium content compared with that from the control euthyroid animals, whereas hyperthyroidism (0.2 mg T3/kg IP; 10 days) upregulated MGP mRNA by 4.5-fold and reduced calcium content by 11%.	Water	90-95	matrix Gla protein	Rattus norvegicus	140-143
16156635-6	2005	The ligands L1 and L2 react cleanly with [99mTc(CO)3(H2O)3]+ in H2O/DMSO to give [99mTc(CO)3(L1)]+ (99m)Tc-1) and [99mTc(CO)3(L2)] (99mTc-2), respectively, in ca.	Water	53-56	transcobalamin 2	Mus musculus	134-139
16156635-6	2005	The ligands L1 and L2 react cleanly with [99mTc(CO)3(H2O)3]+ in H2O/DMSO to give [99mTc(CO)3(L1)]+ (99m)Tc-1) and [99mTc(CO)3(L2)] (99mTc-2), respectively, in ca.	Water	64-67	transcobalamin 2	Mus musculus	134-139
16853151-6	2005	At a membrane-water interface, melittin folds into a secondary alpha-helical structure, and the interfacial water motion was found to take as long as 114 ps, indicating a well-ordered water structure along the membrane surface.	Water	14-19	melittin	Apis mellifera	31-39
16853151-10	2005	Thus, the observed time scale of approximately 100 ps probably implies appropriate water mobility for mediating the formation of high-order structures of melittin in an alpha-helix and a self-assembled tetramer.	Water	83-88	melittin	Apis mellifera	154-162
15860639-6	2005	Pretreatment of mice with 2% DFMO in drinking water significantly reduced apoptotic cells from approximately 2.75 to 1.61 per crypt-villus unit, accompanied by significant decreases in caspase-3 levels.	Water	46-51	caspase 3	Mus musculus	185-194
15936963-5	2005	The most favorable conformation in methanol, water, and probably in the polar (or water medicated) enzyme active sites, however, would be the one in which the carbonyl group is in a transoid position and is syn to Hsyn.	Water	45-50	synemin	Homo sapiens	207-210
15936963-5	2005	The most favorable conformation in methanol, water, and probably in the polar (or water medicated) enzyme active sites, however, would be the one in which the carbonyl group is in a transoid position and is syn to Hsyn.	Water	45-50	RIC8 guanine nucleotide exchange factor B	Homo sapiens	214-218
15936963-5	2005	The most favorable conformation in methanol, water, and probably in the polar (or water medicated) enzyme active sites, however, would be the one in which the carbonyl group is in a transoid position and is syn to Hsyn.	Water	82-87	synemin	Homo sapiens	207-210
15936963-5	2005	The most favorable conformation in methanol, water, and probably in the polar (or water medicated) enzyme active sites, however, would be the one in which the carbonyl group is in a transoid position and is syn to Hsyn.	Water	82-87	RIC8 guanine nucleotide exchange factor B	Homo sapiens	214-218
16112397-5	2005	In in vivo experiments, [Arg14, Lys15] N/OFQ mimicked the effects of N/OFQ, inducing, after intracerebroventricular injection, a delay (up to 70%) in the gastric emptying of a phenol red meal, an increase (about 40 times) of the mean bead colonic expulsion time and a decrease (up to 90%) of gastric acid secretion in water loaded rats after 90 min pylorus ligature.	Water	318-323	prepronociceptin	Mus musculus	39-44
16112397-5	2005	In in vivo experiments, [Arg14, Lys15] N/OFQ mimicked the effects of N/OFQ, inducing, after intracerebroventricular injection, a delay (up to 70%) in the gastric emptying of a phenol red meal, an increase (about 40 times) of the mean bead colonic expulsion time and a decrease (up to 90%) of gastric acid secretion in water loaded rats after 90 min pylorus ligature.	Water	318-323	prepronociceptin	Mus musculus	69-74
16229588-2	2005	Given that the C=O and OH groups in acetic acid provide the predominant hydrogen-bonding interactions with water, six stable conformer structures have been found each for the monohydrate and syn-dihydrate.	Water	107-112	synemin	Homo sapiens	191-194
16229588-3	2005	Of the three syn- and three anti-conformers of acetic acid with water, the most stable monohydrate structure is found to be that of the syn-conformer bonding with water in a cyclic double H-bonded geometry.	Water	64-69	synemin	Homo sapiens	13-16
16229588-3	2005	Of the three syn- and three anti-conformers of acetic acid with water, the most stable monohydrate structure is found to be that of the syn-conformer bonding with water in a cyclic double H-bonded geometry.	Water	64-69	synemin	Homo sapiens	136-139
16229588-3	2005	Of the three syn- and three anti-conformers of acetic acid with water, the most stable monohydrate structure is found to be that of the syn-conformer bonding with water in a cyclic double H-bonded geometry.	Water	163-168	synemin	Homo sapiens	13-16
16229588-3	2005	Of the three syn- and three anti-conformers of acetic acid with water, the most stable monohydrate structure is found to be that of the syn-conformer bonding with water in a cyclic double H-bonded geometry.	Water	163-168	synemin	Homo sapiens	136-139
16229588-4	2005	Similarly, the syn-conformer bonding with two water molecules in a cyclic double H-bonded geometry has also been determined to be the most stable among the six plausible structures for the syn-dihydrate.	Water	46-51	synemin	Homo sapiens	15-18
16229588-4	2005	Similarly, the syn-conformer bonding with two water molecules in a cyclic double H-bonded geometry has also been determined to be the most stable among the six plausible structures for the syn-dihydrate.	Water	46-51	synemin	Homo sapiens	189-192
29569550-9	2005	The accuracy of method was verified using a real sample (spiked tap water) by standard addition calibration technique.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
16046291-3	2005	In study 1, mice were given corticosterone-supplemented water (CORT) for 10 days, resulting in plasma CORT levels within the physiological range, with partial suppression of hypothalamic corticotropin-releasing hormone expression to a similar degree between genotypes.	Water	56-61	cortistatin	Mus musculus	63-67
16046291-3	2005	In study 1, mice were given corticosterone-supplemented water (CORT) for 10 days, resulting in plasma CORT levels within the physiological range, with partial suppression of hypothalamic corticotropin-releasing hormone expression to a similar degree between genotypes.	Water	56-61	cortistatin	Mus musculus	102-106
16046291-3	2005	In study 1, mice were given corticosterone-supplemented water (CORT) for 10 days, resulting in plasma CORT levels within the physiological range, with partial suppression of hypothalamic corticotropin-releasing hormone expression to a similar degree between genotypes.	Water	56-61	corticotropin releasing hormone	Mus musculus	187-218
15994908-7	2005	Arabidopsis plants overexpressing AtERF7 show reduced sensitivity of guard cells to ABA and increased transpirational water loss.	Water	118-123	ethylene response factor 7	Arabidopsis thaliana	34-40
15713911-5	2005	Semiquantitative immunoblotting demonstrated marked suppression of two proteins strongly expressed in the inner medullary collecting duct (IMCD): UT-A1 (a urea transporter) and AQP4 (a basolateral water channel).	Water	197-202	aquaporin 4	Mus musculus	177-181
15976248-4	2005	In the Azunol group, patients gargled with 4 mg Azunol diluted with 100 mL tap water (40 microg/mL).	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
15976248-5	2005	In the control group, patients gargled with 100 mL of tap water.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
16212054-0	2005	[A study of interactions of carbonic anhydrase B with water and urea.	Water	54-59	carbonic anhydrase 2	Homo sapiens	28-48
16212054-5	2005	We found out that native carbonic anhydrase B is able to form water-protein units that are probabilistically distributed with respect to their sizes.	Water	62-67	carbonic anhydrase 2	Homo sapiens	25-45
16212054-6	2005	Large water-protein units can be detected by analyzing the spin-diffusion spectra.	Water	6-11	spindlin 1	Homo sapiens	59-63
16091789-2	2005	Mice that were pretreated with distilled water, s.c., followed 10 min later by administration of 25%, 50%, and 100% concentration ASH, s.c., produced a significant concentration-dependent antinociceptive activity (p &lt; 0.001).	Water	41-46	growth factor receptor bound protein 2	Mus musculus	130-133
32568214-1	2020	Neuromyelitis optica (NMO) is a severe inflammatory autoimmune CNS disorder triggered by binding of an IgG autoantibody to the aquaporin 4 (AQP4) water channel on astrocytes.	Water	146-151	aquaporin 4	Mus musculus	127-138
16002374-1	2005	Individual exposure to trihalomethanes (THMs) in tap water can occur through ingestion, inhalation, or dermal exposure.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
16002374-4	2005	We conducted our study at a single residence in each of two water utility service areas, one with relatively high and the other low total THM in the residence tap water.	Water	163-168	nuclear RNA export factor 1	Homo sapiens	159-162
32568214-1	2020	Neuromyelitis optica (NMO) is a severe inflammatory autoimmune CNS disorder triggered by binding of an IgG autoantibody to the aquaporin 4 (AQP4) water channel on astrocytes.	Water	146-151	aquaporin 4	Mus musculus	140-144
16833878-3	2005	According to quantum mechanical calculations, TBP (modeled by trimethyl phosphate TMP) displays stronger hydrogen-bonding interactions with HNO3 than with H2O, and this has been modeled in force-field calculations.	Water	155-158	TATA-box binding protein	Homo sapiens	46-49
32747978-7	2021	AQP4 resulted the most studied water channel, followed by AQP1.	Water	31-36	aquaporin 4	Homo sapiens	0-4
16833878-4	2005	Different combinations of water, TBP, and acid are compared in SC-CO2 and simulated by molecular dynamics (MD), demonstrating the importance of TBP and water concentrations.	Water	26-31	TATA-box binding protein	Homo sapiens	144-147
16833878-5	2005	In MD simulations, which started from "random" mixtures of water, TBP, nitric acid, and uranyl nitrate, complexation of uranyl by TBP is observed and the yield increases with the TBP concentration.	Water	59-64	TATA-box binding protein	Homo sapiens	130-133
16833878-5	2005	In MD simulations, which started from "random" mixtures of water, TBP, nitric acid, and uranyl nitrate, complexation of uranyl by TBP is observed and the yield increases with the TBP concentration.	Water	59-64	TATA-box binding protein	Homo sapiens	130-133
32533304-2	2020	While many studies have investigated microorganisms in the air and dust, tap water, another major input of microbial propagules, has received far less attention.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
16833819-6	2005	The branching ratio, k1a/k1b, was estimated to be 2.1:1 for reactions (CF3)2CHOCH3 + OH --&gt; (CF3)2CHOCH2*+ H2O (k1a) and (CF3)2CHOCH3 + OH --&gt; (CF3)2C*OCH3 + H2O (k1b).	Water	110-113	keratin 77	Homo sapiens	25-28
16833819-6	2005	The branching ratio, k1a/k1b, was estimated to be 2.1:1 for reactions (CF3)2CHOCH3 + OH --&gt; (CF3)2CHOCH2*+ H2O (k1a) and (CF3)2CHOCH3 + OH --&gt; (CF3)2C*OCH3 + H2O (k1b).	Water	110-113	keratin 77	Homo sapiens	169-172
32533304-12	2020	Microbiota of water-related indoor habitats mainly originates from tap water.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	67-70
15690178-0	2005	Reusable terminal tap water filters for nosocomial legionellosis prevention.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
32533304-12	2020	Microbiota of water-related indoor habitats mainly originates from tap water.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
32199168-0	2020	Occurrence and identification of microplastics in tap water from China.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
15901998-2	2005	A genetic polymorphism of the GSTO1 gene causing an alanine-to-aspartate (A140D) substitution in amino acid 140 produces a variant with lowered enzyme activities in the biotransformation of inorganic arsenic, a common contaminant of drinking water in many regions of the world and a well-known carcinogen.	Water	242-247	glutathione S-transferase omega 1	Homo sapiens	30-35
32199168-2	2020	However, up to now, microplastic contamination in tap water has only been investigated by few studies.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
32199168-5	2020	The amount of microplastics in tap water varied from 440 +- 275 particles L-1.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
15984770-2	2005	The method was applied to 2-methylisoborneol (2-MIB), geosmin, and trans-2,cis-6-nonadienal, which are three of the major odorous compounds found in natural and drinking water.	Water	170-175	MIB E3 ubiquitin protein ligase 1	Homo sapiens	48-51
32199168-6	2020	Particles smaller than 50 mum significantly predominated in most of the tap water samples.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
32199168-7	2020	Further, according to the shape of these particles, fragments, fibers and spheres were found in tap water samples, while fragments were the most abundant morphotype in most samples.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
32199168-9	2020	Based on this investigation, drinking water treatment plants seemingly have to face the problem of microplastic pollution in tap water due to their potential eco-toxicological effects on humans.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	125-128
32199168-9	2020	Based on this investigation, drinking water treatment plants seemingly have to face the problem of microplastic pollution in tap water due to their potential eco-toxicological effects on humans.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
32217410-2	2020	A nationwide survey about ATZ and its degradates (ATZs) in tap water from 31 provinces in 7 regions of mainland China and Hong Kong was conducted during June 2019.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
15923401-9	2005	Immunohistochemical and immunoblot analyses revealed corresponding increases in the level and cellular distributions of the chloride channel CLCN3 and the water channel AQP4, both of which contribute to BBB maintenance.	Water	155-160	aquaporin 4	Mus musculus	169-173
32217410-5	2020	The predominant compounds of ATZs in tap water were ATZ and DEA, with a detection frequency of 99.5% and 98.0%, respectively, followed by ATZ-OH (87.3%), DACT (84.0%), and DIA (78.1%).	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
32548921-0	2020	Is aquaporin-3 involved in water-permeability changes in the killifish during hypoxia and normoxic recovery, in freshwater or seawater?	Water	27-32	aquaporin-3a	Fundulus heteroclitus	3-14
16075942-2	2005	Earlier results from San Francisco suggested an association (OR 6.76) between tap water and cryptosporidiosis among HIV + persons.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
16833735-5	2005	The valence bands of the (100) surfaces of both MgSO(4) and MgSO(4).H(2)O are formed mainly by the O2p levels, whereas the S2p states contribute to the lower part of the conduction band.	Water	68-73	immunoglobulin kappa variable 1D-39	Homo sapiens	99-102
32548921-11	2020	Together, these observations suggest killifish AQP3 contributes to reduced diffusive water flux during hypoxia and normoxic recovery in freshwater and facilitates intestinal permeability in seawater and freshwater.	Water	85-90	aquaporin-3a	Fundulus heteroclitus	47-51
15857133-0	2005	Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).	Water	40-45	ALK receptor tyrosine kinase	Homo sapiens	33-36
15857133-0	2005	Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).	Water	40-45	ALK receptor tyrosine kinase	Homo sapiens	63-66
16981089-4	2006	Tap water was used for irrigations after discharge from hospital.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
33046934-1	2020	In 2018, Cape Town, South Africa, nearly ran out of water.	Water	52-57	structural maintenance of chromosomes 2	Homo sapiens	9-13
15857133-0	2005	Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).	Water	40-45	ALK receptor tyrosine kinase	Homo sapiens	63-66
15790493-0	2005	Genotoxicity and metabolism of the source-water contaminant 1,1-dichloropropene: activation by GSTT1-1 and structure-activity considerations.	Water	42-47	glutathione S-transferase theta 1	Homo sapiens	95-102
32167554-3	2020	In contrast, zebrafish lateral line hair cells, which detect water motion, require Tmc2a and Tmc2b.	Water	61-66	transmembrane channel-like 2a	Danio rerio	83-88
15855348-5	2005	Kallikrein gene transfer also significantly attenuated elevated plasma triglyceride and cholesterol levels, food and water intake, and loss of body weight gain, epididymal fat pad, and gastrocnemius muscle weight in STZ-induced diabetic rats.	Water	117-122	kallikrein related peptidase 4	Homo sapiens	0-10
16866878-8	2006	Instead, water-mediated hydrogen bonding interactions were observed in Rad.	Water	9-14	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	71-74
16902368-6	2006	For public water users, the best-fit model included age, tap water drinks per day, servings of home-grown fruit and vegetables, and carbon filter use.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	57-60
32597180-1	2020	Within the homologous series of amphiphilic peptides AnK, both A8K and A10K self-assemble in water to form twisted-ribbon fibrils with lengths around 100 nm.	Water	93-98	ankyrin 1	Homo sapiens	53-56
16905103-7	2006	As several of those molecules are found at identical positions in the previously solved USP7/ubiquitin-aldehyde complex structure, we suggest a general mechanism of water-mediated ubiquitin recognition by USPs.	Water	165-170	ubiquitin specific peptidase 7	Homo sapiens	88-92
15721893-0	2005	Bladder cancer mortality reduction after installation of a tap-water supply system in an arsenious-endemic area in southwestern Taiwan.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
32498189-0	2020	Spatial variation of 2,4-D and MCPA in tap water and groundwater from China and their fate in source, treated, and tap water from Wuhan, Central China.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
15840783-4	2005	The phenol-water extracts activated human gingival fibroblasts to mediate IL-8 production, as well as IL-8 mRNA expression, phosphorylation of p38 mitogen-activated protein kinase, and expression of intercellular adhesion molecule-1.	Water	11-16	intercellular adhesion molecule 1	Homo sapiens	199-232
16889815-2	2006	Tap water samples collected in the Quebec City (Canada) distribution system on a spatio-temporal basis were subjected to diverse indoor handling scenarios: storing water in the refrigerator, boiling water followed by storage and, finally, filtering water with a point-of-use commercial pitcher also followed by storage.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
16889815-10	2006	Percentages of change in chlorinated DBPs in the different scenarios varied according to initial concentrations in tap water (baseline water), that is, according to the spatio-temporal variations of these substances in the distribution system.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
16889815-10	2006	Percentages of change in chlorinated DBPs in the different scenarios varied according to initial concentrations in tap water (baseline water), that is, according to the spatio-temporal variations of these substances in the distribution system.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	115-118
32498189-6	2020	The cumulative concentration of CPHs (SigmaCPHs) in tap water in China was up to 125 ng/L (median: 1.38 ng/L), and regional variations were found for SigmaCPHs.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
15833348-3	2005	When the methionine-7 (Met-7) residue, which coordinates to the heme iron as an axial ligand, of the wild-type cytochrome b562 was replaced by an Ala or Gly residue, a water molecule bound to the heme iron and the electron transfer rate constants decreased to 1.3 x 10(-3) and 1.8 x 10(-3) cm s(-1), respectively.	Water	168-173	mitochondrially encoded cytochrome b	Homo sapiens	111-123
17723474-5	2006	Water samples including tap water, well water, snow water, reservoir water, and wastewater were analyzed by the proposed procedure and the recoveries at 5 microg L(-1) spiked level were in the range of 86.8-102.6%.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	24-27
32498189-12	2020	Seasonal variations were found in SigmaCPHs in tap water from Wuhan, with the highest found in July (median: 21.2 ng/L), and the lowest in October (1.96 ng/L).	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
32498189-15	2020	Moreover, this study provides an overview of SigmaCPHs in tap water for many areas in China.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
31712142-6	2020	Importantly, our further results in vitro suggested that Myr remarkably attenuated H2O2-triggered hepatotoxicity and ROS generation, activated Keap1-Nrf2/HO-1 and AMPK/ACC signaling pathway.	Water	83-87	kelch-like ECH-associated protein 1	Mus musculus	143-148
16808512-3	2006	On the other hand, when the reaction was carried out in the presence of a catalytic amount of Cu(NTf2)2 and 1 equiv of H2O in (CH2Cl)2 at 100 degrees C, the decarbonylated naphthalene products 4 were obtained selectively over 3.	Water	119-122	nuclear transport factor 2	Homo sapiens	97-101
16827925-5	2006	Treated water was a protective factor against Campylobacter infections in humans with an IRR of 0.78 per percentage increase in people supplied.	Water	8-13	insulin receptor related receptor	Homo sapiens	89-92
16827925-9	2006	Treated water was a protective factor against Campylobacter infections in humans with an IRR of 0.78 per percentage increase in people supplied.	Water	8-13	insulin receptor related receptor	Homo sapiens	89-92
15881090-3	2005	In the present study, water is used as a safe and environmentally friendly solvent in microwave-assisted extraction (MAE) for PCB and CBz analyses.	Water	22-27	Pyruvate carboxylase	Drosophila melanogaster	126-129
16807859-0	2006	Acquisition of multidrug-resistant Serratia marcescens by critically ill patients who consumed tap water during receipt of oral medication.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
32330745-9	2020	Considering all ranking methods shows that among the scenarios, the eighth scenario, including water transfer from Behesht-Abad basin to Isfahan province and from Kharsan basin to Yazd and Kerman provinces, is superior to the other scenarios.	Water	95-100	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	123-127
16807859-2	2006	Examination of the outbreak revealed epidemiological evidence that consumption of tap water from a contaminated faucet during receipt of oral medication was the mechanism of S. marcescens acquisition.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
17092843-4	2006	The desired DES-glutamate 5 was water-soluble and upon incubation with carboxypeptidase G2 (CPG2) underwent carbamate cleavage to give DES 1.	Water	32-37	delta 4-desaturase, sphingolipid 1	Homo sapiens	135-140
15625187-4	2005	Rats were pretreated for 7 d with drinking water containing 0.2 g/l DCAA to deplete the GSTzeta (GSTZ1-1) activity in the liver.	Water	43-48	glutathione S-transferase zeta 1	Rattus norvegicus	97-104
15799243-0	2005	Airborne exposure to trihalomethanes from tap water in homes with refrigeration-type and evaporative cooling systems.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
15799243-1	2005	This study evaluates airborne concentrations of common trihalomethane compounds (THM) in selected living spaces of homes supplied with chlorinated tap water containing &gt;85 ppb total THM.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
32743190-0	2020	Effects of Slug Size, Soaking, and Injection Schemes on the Performance of Controlled Ions Water Flooding in Carbonates.	Water	91-96	snail family transcriptional repressor 2	Homo sapiens	11-15
16799907-3	2006	The antigen responsible for this immune response seems to be aquaporin-4 water channel.	Water	73-78	aquaporin 4	Homo sapiens	61-72
32608904-0	2020	[Occurrence and Prediction Model of Disinfection By-Products in Tap Water].	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
16771323-1	2006	A dendron-like nanostructure of silver was grown in solution using a water-soluble tetrapeptide Tyr-Aib-Tyr-Val (Aib, alpha-amino isobutyric acid), silver nitrate, and methanol.	Water	69-74	ANIB1	Homo sapiens	96-111
16771323-1	2006	A dendron-like nanostructure of silver was grown in solution using a water-soluble tetrapeptide Tyr-Aib-Tyr-Val (Aib, alpha-amino isobutyric acid), silver nitrate, and methanol.	Water	69-74	ANIB1	Homo sapiens	100-103
32608904-3	2020	The purpose of the work was to obtain knowledge on the occurrence of DBPs in tap water and boiled water taken from the same pipe, to establish a statistical model to predict DBPs information in tap water based on physicochemical parameters, and to evaluate carcinogenic and non-carcinogenic risks caused by DBPs on a predictional level.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
32608904-5	2020	The detection rate of target DBPs in tap water was 100% and the concentrations varied in the ranges of 10.12-28.39, 0.98-5.19, and 2.65-7.83 mug L-1, respectively.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
32608904-11	2020	Based on the correlation between the physicochemical parameters and DBPs, a multiple linear regression prediction model of THMs was established, with deviation less than 10.00%, which can be used for the prediction of THMs in tap water.	Water	230-235	nuclear RNA export factor 1	Homo sapiens	226-229
16832971-1	2006	Today, bottled and tap drinking water mainly originates from underground waters which might contain considerable amounts of naturally occurring radionuclides.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	19-22
32608904-14	2020	The carcinogenic risk caused mainly by THMs and bromodicloromethane (BDCM) contributed the highest cancer risk in tap water, while for boiled water, trichloromethane (TCM) was found to contribute the highest cancer and non-carcinogenic risk.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
32369889-4	2020	Furthermore, adsorption isotherms in batch experiments can be used for the determination of the solid-water distribution coefficient (Kid).	Water	102-107	kinesin family member 22	Homo sapiens	134-137
16722628-1	2006	The fast relaxation dynamics of 1,6-dihydro-2-methyl-6-oxo-3,4"-bipyridine-5-carbonitrile (milrinone, MIR), a cardiotonic drug, has been characterized in water solutions at different pH.	Water	154-159	membrane associated ring-CH-type finger 8	Homo sapiens	102-105
32501008-4	2020	When the temperature of the water was varied through phase transition temperature Tp40 (~23 oC), with an area of 40 A2 per nervonic acid molecule in the molecular layer, no motion and oscillatory motion was observed reversibly above and below Tp40, respectively.	Water	28-33	CD7 molecule	Homo sapiens	82-86
16738389-11	2006	Surface water application can be as effective, and less expensive than, standard HDPE tarp.	Water	8-13	TCR gamma alternate reading frame protein	Homo sapiens	86-90
32501008-4	2020	When the temperature of the water was varied through phase transition temperature Tp40 (~23 oC), with an area of 40 A2 per nervonic acid molecule in the molecular layer, no motion and oscillatory motion was observed reversibly above and below Tp40, respectively.	Water	28-33	CD7 molecule	Homo sapiens	243-247
32997445-6	2020	She proved the efficiency of tap water fluoridation in caries prevention through a comparative study on children from schools in Wroclaw and Malbork, where the fluoride concentrations were 0.1 mg/L and 3.2 mg/L, respectively.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
16704279-2	2006	Two distinct structural conformers with the water molecule acting as a proton donor were detected experimentally: one with the water on the same side as the methyl group with respect to the ether ring, i.e., syn-PO-H(2)O, the other with the water molecule binding to the O-atom from the opposite side of the methyl group, i.e., anti-PO-H(2)O.	Water	44-49	synemin	Homo sapiens	208-211
16704279-2	2006	Two distinct structural conformers with the water molecule acting as a proton donor were detected experimentally: one with the water on the same side as the methyl group with respect to the ether ring, i.e., syn-PO-H(2)O, the other with the water molecule binding to the O-atom from the opposite side of the methyl group, i.e., anti-PO-H(2)O.	Water	127-132	synemin	Homo sapiens	208-211
16704279-2	2006	Two distinct structural conformers with the water molecule acting as a proton donor were detected experimentally: one with the water on the same side as the methyl group with respect to the ether ring, i.e., syn-PO-H(2)O, the other with the water molecule binding to the O-atom from the opposite side of the methyl group, i.e., anti-PO-H(2)O.	Water	127-132	synemin	Homo sapiens	208-211
16704279-6	2006	The experimental results suggest that the hydrogen bond in syn-PO-H(2)O is stronger and the monomer subunits are more rigidly locked in their positions than in the ethylene oxide-water adduct.	Water	179-184	synemin	Homo sapiens	59-62
16672062-4	2006	METHODS: The study combined a daily follow-up of digestive morbidity among a panel of 544 volunteers and a microbiological surveillance of tap water.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
32382908-8	2020	The polysilicate aluminium ferric (PSAF) can greatly increase the dewatering efficiency of the filter press membrane, and the final dewatering amount could reach 310 g. The effect of purifying water quality was PSAF>PAM (polyacrylamide, PAM-1(18 million): PAM-2(23 million) = 3:7)>PAC (polyaluminium chloride).	Water	68-73	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	216-219
16306162-0	2006	Differential effects of water and saline intake on water deprivation-induced c-Fos staining in the rat.	Water	24-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	77-82
16306162-0	2006	Differential effects of water and saline intake on water deprivation-induced c-Fos staining in the rat.	Water	51-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	77-82
16306162-6	2006	Rehydration with water significantly decreased AVP levels and Fos staining in the SON, PVN, and RVL and significantly increased Fos expression in the perinuclear zone of the SON, NTS, and parabrachial nucleus.	Water	17-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-65
16306162-6	2006	Rehydration with water significantly decreased AVP levels and Fos staining in the SON, PVN, and RVL and significantly increased Fos expression in the perinuclear zone of the SON, NTS, and parabrachial nucleus.	Water	17-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	128-131
16306162-11	2006	Rehydration with water or saline produces differential effects on plasma AVP, Fos staining, and sodium concentration.	Water	17-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	78-81
32484924-13	2020	SIGNIFICANCE: Posttraumatic seizures (PTSs) may be modulated by the astrocyte water channel AQP4.	Water	78-83	aquaporin 4	Mus musculus	92-96
32208246-0	2020	Perception of tap water quality: Assessment of the factors modifying the links between satisfaction and water consumption behavior.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
16472995-6	2006	It could be shown that povidone K17 effectively prevents recrystallization in solid solutions containing 20% (m/m) of nimodipine during storage at +25 degrees C over silica gel thereby ensuring a substantial increase in the dissolution rate and degree of supersaturation in water.	Water	274-279	keratin 17	Homo sapiens	32-35
32208246-0	2020	Perception of tap water quality: Assessment of the factors modifying the links between satisfaction and water consumption behavior.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	14-17
32208246-1	2020	Perception of tap water is subject to a wide range of factors and interactions.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
32208246-7	2020	Results show that drinking water quality could be loosely linked with overall satisfaction with tap water.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	96-99
32208246-7	2020	Results show that drinking water quality could be loosely linked with overall satisfaction with tap water.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
16534779-2	2006	AQP1, AQP4, and AQP9 have been identified in the central nervous system and demonstrated or proposed to play important roles in brain water homeostasis.	Water	134-139	aquaporin 4	Homo sapiens	6-10
32208246-8	2020	The water consumption profile was strongly linked with satisfaction levels related to the taste, odor and color of tap water.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	115-118
32208246-8	2020	The water consumption profile was strongly linked with satisfaction levels related to the taste, odor and color of tap water.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
32208246-9	2020	We observed that the association between an individual"s tap water satisfaction and water consumption behavior was mediated by the water treatment strategies applied at home (filtering, cooling), knowledge about drinking water quality and its production, and risk perception.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
16679899-4	2006	This work addresses the issue of how the current safety standard for tap water temperature could be adjusted to provide a level of protection to children equivalent to that for an adult at 120 degrees F. A well-accepted mathematical model for predicting burn injury as a function of applied surface temperature and time is used to identify these equivalent conditions.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
32208246-9	2020	We observed that the association between an individual"s tap water satisfaction and water consumption behavior was mediated by the water treatment strategies applied at home (filtering, cooling), knowledge about drinking water quality and its production, and risk perception.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	57-60
32208246-9	2020	We observed that the association between an individual"s tap water satisfaction and water consumption behavior was mediated by the water treatment strategies applied at home (filtering, cooling), knowledge about drinking water quality and its production, and risk perception.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	57-60
32208246-9	2020	We observed that the association between an individual"s tap water satisfaction and water consumption behavior was mediated by the water treatment strategies applied at home (filtering, cooling), knowledge about drinking water quality and its production, and risk perception.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	57-60
17704842-0	2006	Effect of water restrictions on the physiological parameters, psychological behavior and brain c-Fos expression in rats.	Water	10-15	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	95-100
32208246-10	2020	The mediating effects were shown to be significant mainly among bottled-water-only and tap-water-only consumers.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
32208246-11	2020	Future interventions that aim to encourage the population"s use of tap water as a primary source should prioritize cooling and filtering tap water in their messaging, in order to improve population satisfaction.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
32208246-11	2020	Future interventions that aim to encourage the population"s use of tap water as a primary source should prioritize cooling and filtering tap water in their messaging, in order to improve population satisfaction.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	137-140
32208282-7	2020	The reclaimed water satisfied the physico-chemical and microbiological quality requirements only after additional NF/RO treatment.	Water	14-19	neurofascin	Homo sapiens	114-119
16713493-3	2006	Mice lacking functional AQP2, AQP3, or AQP4 manifest various degrees of nephrogenic diabetes insipidus resulting from reduced collecting duct water permeability.	Water	142-147	aquaporin 4	Mus musculus	39-43
32407616-3	2020	Herein, we demonstrate that a three-dimensional all-fiber aerogel (3D AFA), which can float on water surface and continuously self-pump water.	Water	95-100	AFA	Homo sapiens	70-73
16284957-11	2006	The association of bladder cancer with tap water consumption, but not with nontap water fluids, suggests that carcinogenic chemicals in tap water may explain the increased risk.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
32407616-3	2020	Herein, we demonstrate that a three-dimensional all-fiber aerogel (3D AFA), which can float on water surface and continuously self-pump water.	Water	136-141	AFA	Homo sapiens	70-73
32181560-2	2020	However, the photocatalytic overall water splitting still remains challenging due to the slow water oxidation kinetics, severe reverse reaction and H 2 /O 2 gas separation.	Water	36-41	immunoglobulin kappa variable 1D-39	Homo sapiens	153-156
16491497-2	2006	The water-soluble PEG-supported ruthenium porphyrin (PEG-1) is an efficient catalyst for 2,6-Cl(2)pyNO oxidation and PhI==NTs aziridination/amidation of hydrocarbons, and intramolecular amidation of sulfamate esters with PhI(OAc)(2).	Water	4-9	mesoderm specific transcript	Homo sapiens	53-58
16491497-3	2006	Oxidation of PEG-1 by m-CPBA in CH(2)Cl(2), dioxane, or water afforded a water-soluble PEG-supported dioxoruthenium(VI) porphyrin (PEG-2), which could react with hydrocarbons to give oxidation products in up to 80 % yield.	Water	56-61	mesoderm specific transcript	Homo sapiens	13-18
16491497-3	2006	Oxidation of PEG-1 by m-CPBA in CH(2)Cl(2), dioxane, or water afforded a water-soluble PEG-supported dioxoruthenium(VI) porphyrin (PEG-2), which could react with hydrocarbons to give oxidation products in up to 80 % yield.	Water	73-78	mesoderm specific transcript	Homo sapiens	13-18
15739009-2	2005	Coordination of a water or an acetonitrile molecule was found in the trigonal plane of the five-coordinate Cu(ii) complex in the Tbp(trigonal bipyramidal) structure.	Water	18-23	TATA-box binding protein	Homo sapiens	129-132
16434195-2	2006	Herein, we describe another approach to improve factor Xa inhibitory potency and pharmacokinetic profile by incorporating basic and water soluble functionalities on the terminal ring of the P4 biaryl group found in our earlier Xa inhibitors.	Water	132-137	coagulation factor X	Homo sapiens	48-57
16581538-9	2006	For chloroform from showering, strong correlations were observed for indoor air and exhaled breath, blood and exhaled breath, indoor air and blood, and tap water and blood.	Water	156-161	nuclear RNA export factor 1	Homo sapiens	152-155
16115838-9	2006	Tap water sprinkling and occasionally alcohol were used.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
16183240-2	2006	After extraction of lincomycin from premix with extraction solvent the extract is applied to OASIS HLB column treated with methanol and water.	Water	136-141	cAMP responsive element binding protein 3 like 1	Homo sapiens	93-98
16344970-7	2006	Deviations between the geometry and energetics of the most analogous models and the PHM crystal structures suggest that the protein environment influences the coordination geometry at the Cu(B) site and increases the lability of water bound to the preoxygenated reduced form.	Water	229-234	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	84-87
16464240-5	2006	In support of this, it was observed that hippocampal MMP-3 and -9 increased transiently during water maze acquisition as assessed by western blotting and mRNA analysis.	Water	95-100	matrix metallopeptidase 3	Rattus norvegicus	53-65
16604844-4	2006	Approximately 49% of households used water treatment devices to treat their tap water.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	76-79
16604844-4	2006	Approximately 49% of households used water treatment devices to treat their tap water.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
16174867-1	2006	Atrial natriuretic peptide (ANP) acutely promotes water and sodium excretion, whereas subchronic effects involve water retention.	Water	50-55	natriuretic peptide A	Rattus norvegicus	0-26
16174867-1	2006	Atrial natriuretic peptide (ANP) acutely promotes water and sodium excretion, whereas subchronic effects involve water retention.	Water	50-55	natriuretic peptide A	Rattus norvegicus	28-31
16174867-4	2006	The fractional distal water excretion was significantly increased initially and then decreased in response to ANP.	Water	22-27	natriuretic peptide A	Rattus norvegicus	110-113
16484720-1	2006	lipase at high water content.	Water	15-20	GDSL esterase/lipase At5g18430-like	Gossypium hirsutum	0-6
16484720-2	2006	A new process for enzymatic synthesis of biodiesel at high water content (10-20%) with 96% conversion by lipase from Candida sp.	Water	59-64	GDSL esterase/lipase At5g18430-like	Gossypium hirsutum	105-111
16365868-0	2006	Gaseous reaction mechanism of C2F radical with water.	Water	47-52	EMG1 N1-specific pseudouridine methyltransferase	Homo sapiens	30-33
16365868-2	2006	In this article, a detailed mechanistic study was reported on the gas-phase reaction between the simplest pi-bonded C2F radical and water as the first attempt to understand the chemical reactivity of the C2F radical.	Water	132-137	EMG1 N1-specific pseudouridine methyltransferase	Homo sapiens	116-119
16365868-2	2006	In this article, a detailed mechanistic study was reported on the gas-phase reaction between the simplest pi-bonded C2F radical and water as the first attempt to understand the chemical reactivity of the C2F radical.	Water	132-137	EMG1 N1-specific pseudouridine methyltransferase	Homo sapiens	204-207
16374796-8	2006	In water-deprived rats (n=4), numerous VGLUT2 mRNA-positive PVH neurons retrogradely labeled from the ipsilateral RVLM with CTB were c-Fos-ir (16-40%, depending on PVH region).	Water	3-8	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	124-127
16311720-1	2006	Previously (Wellner et al., Pflugers Arch 441:49-56, 2000) we suggested that the localization of the aquaporins (AQPs) AQP5 and AQP8 in the apical and basolateral membranes of rat submandibular gland (SMG) acinar cells, respectively, provides for transcellular water flow during saliva formation.	Water	261-266	aquaporin 5	Rattus norvegicus	119-123
16422608-1	2006	The infrared spectrum of the complex between o-H2 and H2O, D2O, or HDO, isolated in a matrix of solid p-H2, has been studied between 20 and 4500 cm(-1).	Water	54-57	polyhomeotic homolog 2	Homo sapiens	102-106
16298016-2	2006	A tap water tracer was injected into a fracture-dominated, salt-water plume formed during a previous salt-water injection experiment.	Water	6-11	nuclear RNA export factor 1	Homo sapiens	2-5
16298016-2	2006	A tap water tracer was injected into a fracture-dominated, salt-water plume formed during a previous salt-water injection experiment.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	2-5
16298016-2	2006	A tap water tracer was injected into a fracture-dominated, salt-water plume formed during a previous salt-water injection experiment.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	2-5
16298016-3	2006	The tap water tracer was injected into a central injection well under constant hydraulic head for 34 days.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
16282331-2	2006	Additionally, the 10-kDa PsbR protein has been found in plant PSII and anticipated to play a role in water oxidation, yet the physiological significance of PsbR has remained obscure.	Water	101-106	photosystem II subunit R	Arabidopsis thaliana	25-29
16543716-1	2006	The weak inward rectifier potassium channel ROMK is important for water and salt reabsorption in the kidney.	Water	66-71	potassium inwardly rectifying channel subfamily J member 1 S homeolog	Xenopus laevis	44-48
16023177-1	2006	The paper presents the results of determination of volatile organohalogen compounds (VOX) in urine samples from subjects exposed to these compounds in their workplaces and through consumption of chlorinated tap water.	Water	211-216	nuclear RNA export factor 1	Homo sapiens	207-210
16023177-7	2006	Their presence in the organisms was most probably related to consumption of tap water produced by chlorination of surface waters.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
16154195-2	2006	The most dominant THM compounds are chloroform, bromodichloromethane (BDCM), and dibromochloromethane (DBCM) in Istanbul tap water.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
16154195-5	2006	The lifetime cancer risks of chloroform, BDCM, and DBCM from tap water of all 15 districts were higher than 10(-6), the negligible risk level defined by the USEPA.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
16337684-2	2006	In water, the reaction with CdCl2 afforded [CdCl2(OxT)], but reaction with ZnCl2 or HgCl2 yielded unidentified products.	Water	3-8	oxytocin/neurophysin I prepropeptide	Homo sapiens	50-53
16523430-2	2006	Short daily HD (sDHD = 2 hr x 6/week) seems to allow reductions in left ventricular mass (LVM) through the reduction of extracellular water (ECW).	Water	134-139	succinate dehydrogenase complex subunit D	Homo sapiens	16-20
16395432-10	2006	The radical ion Cl2- could be successfully detected by photolysing in 2-propanol-water (1 : 1) in the presence of Cl-.	Water	81-86	endogenous retrovirus group W member 5	Homo sapiens	16-19
16702240-3	2006	The mean values of tap water and well water were found to be 12 kBq m(-3) with a maximum of 18 kBq m(-3) and 41 kBq m(-3) with a maximum of 127 kBq m(-3), respectively.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
16440156-1	2006	PURPOSE: In Japan, sterile water is used for rinsing in surgical handwashing, whereas in Western countries tap water is generally used.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
16440156-2	2006	We conducted this study to examine the conditions and the equipment that affect bacterial contamination in tap water and to determine whether the tap water in our institute is suitable for surgical handwashing.	Water	150-155	nuclear RNA export factor 1	Homo sapiens	146-149
16440156-3	2006	METHODS: First, we examined the water pipes and measured the free chlorine content in the tap water in the operating room.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
16440156-6	2006	RESULTS: The mean free chlorine levels in the tap water and the sterile water were 0.30 +/- 0.05 and 0.07 +/- 0.03 mg/l, respectively.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
16440156-7	2006	The handwashing test using tap water showed immediate, persistent, and cumulative bacteria activity within the minimum limits set by the Food and Drug Administration (FDA).	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
16440156-8	2006	CONCLUSION: The free chlorine levels in the tap water in our institute satisfied Japanese health regulations.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
16440156-10	2006	Thus, we conclude that this tap water is safe to use for rinsing in surgical handwashing.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
16303850-1	2005	Aquaporin-4, the major water-selective channel in astroglia throughout the central nervous system, facilitates water movement into and out of the brain.	Water	23-28	aquaporin 4	Mus musculus	0-11
16303850-1	2005	Aquaporin-4, the major water-selective channel in astroglia throughout the central nervous system, facilitates water movement into and out of the brain.	Water	111-116	aquaporin 4	Mus musculus	0-11
16303850-6	2005	Astroglial cell migration was enhanced by a small extracellular osmotic gradient, suggesting that aquaporin-4 facilitates water influx across the leading edge of a migrating cell.	Water	122-127	aquaporin 4	Mus musculus	98-109
16154530-1	2005	O2-dependent reactions of the ferric and ferrous forms of alpha-hydroxyheme complexed with water-soluble rat heme oxygenase-1 were examined by rapid-scan stopped-flow measurements.	Water	91-96	heme oxygenase 1	Rattus norvegicus	109-125
16363785-8	2005	The water pixels are described with the Nakajima-Tanaka BRF model of wind-roughened water surface with a Lambertian offset, which is designed to model approximately the reflectance of suspended matter and of a shallow lake or river bottom.	Water	4-9	BRF1 RNA polymerase III transcription initiation factor subunit	Homo sapiens	56-59
15915539-5	2005	The RDS were within the range 1.7-4.1% for water and 0.9-1.2% for soil samples.	Water	43-48	peripherin 2	Homo sapiens	4-7
16214338-4	2005	The X-ray crystallographic structure of the hCA II-l-His adduct showed the activator to be anchored at the entrance of the active site cavity, participating in an extended network of hydrogen bonds with the amino acid residues His64, Asn67, and Gln92 and, with three water molecules connecting it to the zinc-bound water.	Water	267-272	carbonic anhydrase 2	Homo sapiens	44-50
16214338-4	2005	The X-ray crystallographic structure of the hCA II-l-His adduct showed the activator to be anchored at the entrance of the active site cavity, participating in an extended network of hydrogen bonds with the amino acid residues His64, Asn67, and Gln92 and, with three water molecules connecting it to the zinc-bound water.	Water	315-320	carbonic anhydrase 2	Homo sapiens	44-50
16359479-1	2005	PURPOSE: The aim of the present study was to determine whether an increased water content during thermal cycling of hot water-treated acrylic was associated with a reduction in surface hardness and an increased opacity or whitening of the surface.	Water	76-81	alcohol dehydrogenase iron containing 1	Homo sapiens	116-119
16359479-6	2005	RESULTS: The hot water-treated specimens were much whiter than the warm water-treated specimens.	Water	17-22	alcohol dehydrogenase iron containing 1	Homo sapiens	13-16
16359479-11	2005	We attribute the whitening and reduction in the hardness of the hot water-treated specimens to absorption of water and a disruption of the acrylic surface structure.	Water	68-73	alcohol dehydrogenase iron containing 1	Homo sapiens	64-67
16359479-11	2005	We attribute the whitening and reduction in the hardness of the hot water-treated specimens to absorption of water and a disruption of the acrylic surface structure.	Water	109-114	alcohol dehydrogenase iron containing 1	Homo sapiens	64-67
16025300-7	2005	In summary, mice deficient for TWIK-1 presented impaired regulation of (i) Pi transport in proximal tubule and (ii) water transport in medullary collecting duct.	Water	116-121	potassium channel, subfamily K, member 1	Mus musculus	31-37
16161116-3	2005	Since the acquisition of structural information for elastin is hampered by its extreme insolubility in water or any organic solvent, in this study, human skin elastin was digested with elastase to produce water-soluble peptides.	Water	205-210	elastin	Homo sapiens	159-166
16272281-5	2005	MyD88-/- mice were completely resistant to EAU and had a profound defect in Th1, but not Th2, responses to autoantigen challenge.	Water	43-46	myeloid differentiation primary response gene 88	Mus musculus	0-5
16523710-0	2005	[G6PD phenotype and red blood cell sensitivity to the oxidising action of chlorites in drinking water].	Water	96-101	glucose-6-phosphate dehydrogenase	Homo sapiens	1-5
16358785-11	2005	The interaction of R24571 with the CaM-Ca2+ complex results in quenching of fluorescence to its level in water, which is interpreted as the elimination of the availability of calmodulin hydrophobic site for chlortetracycline-Ca+.	Water	105-110	calmodulin 2	Mus musculus	35-38
16358785-11	2005	The interaction of R24571 with the CaM-Ca2+ complex results in quenching of fluorescence to its level in water, which is interpreted as the elimination of the availability of calmodulin hydrophobic site for chlortetracycline-Ca+.	Water	105-110	calmodulin 2	Mus musculus	175-185
16251788-2	2005	Towards this goal we first established protocols to induce and score caries in NFS/N mice and determined caries susceptibility in mice with targeted deletion of the gene encoding aquaporin-5 (Aqp5-/-), a water channel involved in the production of saliva.	Water	204-209	aquaporin 5	Mus musculus	179-190
16251788-2	2005	Towards this goal we first established protocols to induce and score caries in NFS/N mice and determined caries susceptibility in mice with targeted deletion of the gene encoding aquaporin-5 (Aqp5-/-), a water channel involved in the production of saliva.	Water	204-209	aquaporin 5	Mus musculus	192-200
16293772-7	2005	In experiment 3, 13-week-old goats were injected with CRH alone followed by injection with AVP for two consecutive days of water deprivation.	Water	123-128	vasopressin-neurophysin 2-copeptin	Capra hircus	91-94
15960590-0	2005	Preclinical evaluation of a novel water-soluble chlorin E6 derivative (BLC 1010) as photosensitizer for the closure of the neovessels.	Water	34-39	C-X-C motif chemokine ligand 13	Homo sapiens	71-74
16182260-5	2005	Water and saline intakes were increased to a similar extent by 125 and 1250 pmol of [D-Asp1D-Arg2]AngII.	Water	0-5	arginase 2	Rattus norvegicus	93-97
16182260-7	2005	Pretreatment with EC33 or PC18 decreased water and saline intakes in response to [D-Asp1D-Arg2]AngII, while pretreatment with PC18 altered the time course of the [D-Arg1]AngIII-induced water and saline intakes.	Water	41-46	arginase 2	Rattus norvegicus	90-94
16168966-0	2005	Corticosterone release is heightened in food or water deprived oxytocin deficient male mice.	Water	48-53	oxytocin	Mus musculus	63-71
16187986-0	2005	Water homeostasis in the ischaemic retina: is aquaporin-4 involved?	Water	0-5	aquaporin 4	Homo sapiens	46-57
16187988-5	2005	The ion fluxes into the retinal neurons are associated with water movements that are mediated by aquaporin-4 water channels expressed by Muller cells and result in neuronal cell swelling.	Water	60-65	aquaporin 4	Homo sapiens	97-108
16186359-3	2005	In CCR5-deficient mice, we examined the role of CCR5 in the development of EAU induced by immunization with interphotoreceptor retinoid-binding protein (IRBP) peptide.	Water	75-78	retinol binding protein 3, interstitial	Mus musculus	108-151
16186359-3	2005	In CCR5-deficient mice, we examined the role of CCR5 in the development of EAU induced by immunization with interphotoreceptor retinoid-binding protein (IRBP) peptide.	Water	75-78	retinol binding protein 3, interstitial	Mus musculus	153-157
16181429-2	2005	Aquaporin-4 (AQP4) is a water channel expressed in astroglia at the blood-brain and brain-CSF barriers.	Water	24-29	aquaporin 4	Mus musculus	0-11
16181429-2	2005	Aquaporin-4 (AQP4) is a water channel expressed in astroglia at the blood-brain and brain-CSF barriers.	Water	24-29	aquaporin 4	Mus musculus	13-17
16181429-2	2005	Aquaporin-4 (AQP4) is a water channel expressed in astroglia at the blood-brain and brain-CSF barriers.	Water	24-29	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	90-93
16181429-6	2005	However, at 3 days the AQP4 null mice had significantly higher intracranial pressure (mean +/- SEM 27 +/- 2 vs. 17 +/- 2 mmHg; p &lt; 0.001) and brain water content (81.0 +/- 0.3 vs. 79.3 +/- 0.5 % water by weight in the abscess-containing hemisphere; p &lt; 0.01) than wild-type mice.	Water	151-156	aquaporin 4	Mus musculus	23-27
16181429-6	2005	However, at 3 days the AQP4 null mice had significantly higher intracranial pressure (mean +/- SEM 27 +/- 2 vs. 17 +/- 2 mmHg; p &lt; 0.001) and brain water content (81.0 +/- 0.3 vs. 79.3 +/- 0.5 % water by weight in the abscess-containing hemisphere; p &lt; 0.01) than wild-type mice.	Water	198-203	aquaporin 4	Mus musculus	23-27
16194264-1	2005	Aquaporin 4 (AQP4) has an important role in water homeostasis of human brain and a dysfunction of AQP4 could induce pathological conditions in neuronal activity.	Water	44-49	aquaporin 4	Homo sapiens	0-11
16194264-1	2005	Aquaporin 4 (AQP4) has an important role in water homeostasis of human brain and a dysfunction of AQP4 could induce pathological conditions in neuronal activity.	Water	44-49	aquaporin 4	Homo sapiens	13-17
15845093-8	2005	We then confirmed that c-Fos was induced in 60% of relaxin 3 neurons in the NI and the expression of relaxin 3 mRNA increased significantly in the NI after water-restraint stress.	Water	156-161	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-28
15611083-7	2005	Importantly, wild type Fps1 and Fps1-Delta1 showed similarly low permeability for water.	Water	82-87	Fps1p	Saccharomyces cerevisiae S288C	23-27
15611083-7	2005	Importantly, wild type Fps1 and Fps1-Delta1 showed similarly low permeability for water.	Water	82-87	Fps1p	Saccharomyces cerevisiae S288C	32-36
15611033-8	2005	In a parallel set of experiments, acute rehydration of 48 h water-deprived rats significantly attenuated the increased Fos immunoreactivity in PVN neurones that project to the spinal cord or rostral ventrolateral medulla.	Water	60-65	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	119-122
15681865-3	2005	The conformation of mDHFR Arg22 is such that it makes hydrogen-bonding contacts with Asp21, Trp24 and a structural water molecule, observations which were not made in the L22R hDHFR ternary complex.	Water	115-120	dihydrofolate reductase	Mus musculus	20-25
15494214-5	2005	We give evidence that two agonists, the specific alpha(1)-adrenergic agonist, phenylephrine and the water-soluble lipid mitogen, lysophosphatidic acid (LPA) activate NHE1 in CCL39 cells.	Water	100-105	sodium/hydrogen exchanger 1	Cricetulus griseus	166-170
15804764-3	2005	METHODS: EAU was induced in B10.RIII mice by immunization with interphotoreceptor retinoid-binding protein (IRBP) using routine methods, but without treatment with pertussis toxin (PTX).	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	63-106
15804764-3	2005	METHODS: EAU was induced in B10.RIII mice by immunization with interphotoreceptor retinoid-binding protein (IRBP) using routine methods, but without treatment with pertussis toxin (PTX).	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	108-112
16581373-5	2005	The second study discusses a 2-ns simulation of bovine pancreatic trypsin inhibitor (BPTI) in water using a variety of fixed charge and polarizable models for both the protein and the solvent, analyzing observed root mean square deviations (RMSD), intraprotein hydrogen bonding, and water structure and dynamics.	Water	94-99	spleen trypsin inhibitor I	Bos taurus	85-89
15458969-5	2005	The number of c-Fos-positive cells in the SON was significantly increased after 24 and 48 h of water deprivation.	Water	95-100	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-19
15458969-7	2005	Water deprivation significantly increased c-Fos staining in both the OVLT and the MnPO, but c-Fos staining was not altered by rehydration.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	42-47
15458969-8	2005	FosB staining in the SON was significantly increased only by 48-h water deprivation, and this effect was significantly decreased by rehydration.	Water	66-71	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-4
15458969-9	2005	In the MnPO and OVLT, FosB staining was significantly increased by water deprivation, and, like c-Fos staining, these increases were not affected by rehydration.	Water	67-72	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	22-26
15458969-12	2005	We conclude that water deprivation and rehydration differentially affect c-Fos and FosB staining in a region-dependent manner.	Water	17-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	73-78
15458969-12	2005	We conclude that water deprivation and rehydration differentially affect c-Fos and FosB staining in a region-dependent manner.	Water	17-22	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-87
15986999-38	2005	CONCLUSION: These experiments of this study showed that the effects of Cl- concentration of the water and the chemical structure of the substances is more than that of the pH on the AOX formation.	Water	96-101	acyl-CoA oxidase 1	Homo sapiens	182-185
16596811-4	2005	For instance, the ABCG5/ABCG8 couple is crucial for hepatobiliary and intestinal cholesterol excretion, while ABCA1 is essential for high-density lipoprotein formation and, hence, for inter-organ trafficking of the highly water-insoluble cholesterol molecules.	Water	222-227	ATP binding cassette subfamily G member 8	Homo sapiens	24-29
16596811-4	2005	For instance, the ABCG5/ABCG8 couple is crucial for hepatobiliary and intestinal cholesterol excretion, while ABCA1 is essential for high-density lipoprotein formation and, hence, for inter-organ trafficking of the highly water-insoluble cholesterol molecules.	Water	222-227	ATP binding cassette subfamily A member 1	Homo sapiens	110-115
26641127-0	2005	Efficient Simulation Method for Polarizable Protein Force Fields:  Application to the Simulation of BPTI in Liquid Water.	Water	115-120	spleen trypsin inhibitor I	Bos taurus	100-104
26641127-1	2005	A methodology for large scale molecular dynamics simulation of a solvated polarizable protein, using a combination of permanent and inducible point dipoles with fluctuating and fixed charges, is discussed and applied to the simulation of water solvated bovine pancreatic trypsin inhibitor (BPTI).	Water	238-243	spleen trypsin inhibitor I	Bos taurus	290-294
15610242-2	2005	Within the kidney, these stimuli converge on the CaSR to coordinate systemic calcium and water homeostasis.	Water	89-94	calcium-sensing receptor	Rattus norvegicus	49-53
15590158-11	2005	Of those responsive to tap water, 47%, 50%, and 4% exhibited immunoreactivity for Glu-, SP- and CGRP, respectively.	Water	27-32	USO1 vesicle transport factor	Rattus norvegicus	23-26
15680690-10	2005	These findings demonstrate that circuits involving contacts between mossy fibre terminals and CA3 pyramidal cells at stratum lucidum level are affected conversely by water maze training and chronic stress, confirming the remarkable plasticity of CA3 dendrites.	Water	166-171	carbonic anhydrase 3	Rattus norvegicus	94-97
15680690-10	2005	These findings demonstrate that circuits involving contacts between mossy fibre terminals and CA3 pyramidal cells at stratum lucidum level are affected conversely by water maze training and chronic stress, confirming the remarkable plasticity of CA3 dendrites.	Water	166-171	carbonic anhydrase 3	Rattus norvegicus	246-249
15852985-5	2005	Abluent could eliminate nitrite effectively, whose efficiency was 1-5 times higher than that of tap water.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
15456757-7	2004	Moreover, unlike Ec-Lon, Mj-Lon has a buried cavity in the region of the active site containing three water molecules, one of which is hydrogen-bonded to catalytic Ser-550.	Water	102-107	putative ATP-dependent Lon protease	Escherichia coli	28-31
15456757-8	2004	The geometry and environment of the active site residues in Mj-Lon suggest that the charged Lys-593 assists in lowering the pK(a) of the Ser-550 hydroxyl group via its electrostatic potential, and the water in the cavity acts as a proton acceptor during catalysis.	Water	201-206	putative ATP-dependent Lon protease	Escherichia coli	63-66
15583134-9	2004	Taken together, Aqy1 is developmentally controlled and may play a role in spore maturation, probably by allowing water outflow.	Water	113-118	Aqy1p	Saccharomyces cerevisiae S288C	16-20
15571401-6	2004	These results are interpreted as indicating the presence of two species, namely Z- and E-2-(carboxymethylene)-1,2-dihydropyridines (2-13), resulting from conjugate 1,4-addition of H(2)O to 2-4.	Water	180-185	cystatin 12, pseudogene	Homo sapiens	87-90
15325464-7	2004	CBs appeared to be the pesticides most responsible for BChE inhibition because most of the samples showed reactivation of BChE activity after water treatment (63.3% from Fuencaliente and 29% from Tazacorte).	Water	142-147	cholinesterase	Serinus canaria	55-59
15898955-3	2005	In the present study, we investigated the expression of AQP4 (aquaporin 4) water channel and H(+)/K(+)-ATPase in stomachs from both control and transgenic mice.	Water	75-80	aquaporin 4	Mus musculus	56-60
15898955-3	2005	In the present study, we investigated the expression of AQP4 (aquaporin 4) water channel and H(+)/K(+)-ATPase in stomachs from both control and transgenic mice.	Water	75-80	aquaporin 4	Mus musculus	62-73
15325464-7	2004	CBs appeared to be the pesticides most responsible for BChE inhibition because most of the samples showed reactivation of BChE activity after water treatment (63.3% from Fuencaliente and 29% from Tazacorte).	Water	142-147	cholinesterase	Serinus canaria	122-126
32193076-3	2020	At present, one of the most significant concerns for this process is regarding the sustainable management of municipal NF/RO concentrate, due to a potentially serious threat to water receiving body.	Water	177-182	neurofascin	Homo sapiens	119-124
15570134-7	2004	In both patient groups, upright immersion to the neck and supine body position at rest in the water resulted in abnormal mean pulmonary artery pressure (PAm) and mean pulmonary capillary pressures (PCPm), respectively.	Water	94-99	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	153-156
16279736-5	2005	Water sorption rates also differed significantly (p &lt; 0.05)--namely 3.0 and 2.8 mg/cm2 for SLM-1 after one day and three months respectively, and 2.0 and 2.2 mg/cm2 for SLM-2.	Water	0-5	KH RNA binding domain containing, signal transduction associated 2	Homo sapiens	94-99
32566816-7	2020	Regarding the reaction temperature of the water insertion into rhombohedral RE2(SO4)3 (RE = Yb, Y, Dy) to form RE2(SO4)3 H2O, it increases as the ionic radius of RE3+ becomes larger.	Water	42-47	G protein-coupled receptor 161	Homo sapiens	76-85
16163011-10	2005	The high frequency of Acanthamoeba infection strongly suggests that tap water rinsing should be eliminated from the lens care regimen for overnight OK.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
15572847-5	2004	From this morphologic evidence, it is proposed that beta(2)-AR activation may regulate glomerular function and thereby sodium and water balance in the nephron segments.	Water	130-135	adrenoceptor beta 2	Homo sapiens	52-62
15271657-1	2004	The present study sought to determine whether water deprivation increases Fos immunoreactivity, a neuronal marker related to synaptic activation, in sympathetic-regulatory neurons of the hypothalamic paraventricular nucleus (PVN).	Water	46-51	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-77
16105031-1	2005	Guanylin and uroguanylin were proposed as first hormones linking intestinal with renal electrolyte and water transport, which is disturbed in pathophysiology.	Water	103-108	guanylate cyclase activator 2a (guanylin)	Mus musculus	0-8
15271657-3	2004	Rats were then deprived of water but not food for 48 h. Water deprivation significantly increased the number of Fos-positive nuclei throughout the dorsal, ventrolateral, and lateral parvocellular divisions of the PVN (water deprived, 215 +/- 23 cells; control, 45 +/- 7 cells, P &lt; 0.01).	Water	56-61	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-115
32566816-7	2020	Regarding the reaction temperature of the water insertion into rhombohedral RE2(SO4)3 (RE = Yb, Y, Dy) to form RE2(SO4)3 H2O, it increases as the ionic radius of RE3+ becomes larger.	Water	42-47	G protein-coupled receptor 161	Homo sapiens	111-120
15271657-3	2004	Rats were then deprived of water but not food for 48 h. Water deprivation significantly increased the number of Fos-positive nuclei throughout the dorsal, ventrolateral, and lateral parvocellular divisions of the PVN (water deprived, 215 +/- 23 cells; control, 45 +/- 7 cells, P &lt; 0.01).	Water	218-223	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-115
32566816-7	2020	Regarding the reaction temperature of the water insertion into rhombohedral RE2(SO4)3 (RE = Yb, Y, Dy) to form RE2(SO4)3 H2O, it increases as the ionic radius of RE3+ becomes larger.	Water	121-124	G protein-coupled receptor 161	Homo sapiens	76-85
15271657-4	2004	Moreover, a significantly greater number of Fos-positive nuclei were localized in spinally projecting (11 +/- 3 vs. 2 +/- 1 cells, P &lt; 0.025) and RVLM-projecting (45 +/- 7 vs. 7 +/- 1 cells, P &lt; 0.025) neurons of the PVN in water-deprived vs. control rats, respectively.	Water	230-235	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	44-47
16015024-0	2005	Gender difference of in vivo skin surface pH in the axilla and the effect of a standardized washing procedure with tap water.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
15271657-7	2004	In addition, we analyzed spinally projecting neurons of the RVLM and found a significantly greater percentage were Fos positive in water-deprived rats than in control rats (26 +/- 3 vs. 3 +/- 1%, respectively; P &lt; 0.001).	Water	131-136	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	115-118
32566816-7	2020	Regarding the reaction temperature of the water insertion into rhombohedral RE2(SO4)3 (RE = Yb, Y, Dy) to form RE2(SO4)3 H2O, it increases as the ionic radius of RE3+ becomes larger.	Water	121-124	G protein-coupled receptor 161	Homo sapiens	111-120
32448085-3	2021	The first step in this investigation was to solvate the isolated S-protein in water for molecular dynamics (MD) simulation, being observed a transition from "up" to "down" conformation of receptor-binding domain (RBD) of the S-protein with angle of 54.3 and 43.0 degrees, respectively.	Water	78-83	vitronectin	Homo sapiens	65-74
15508038-8	2004	Finally, the electrode was applied to different real samples (tap-water, urine and wine) for the analysis of trace metals with satisfactory results.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	120-125	ATP binding cassette subfamily B member 11	Homo sapiens	363-367
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	120-125	ATP binding cassette subfamily C member 2	Homo sapiens	399-403
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	174-179	ATP binding cassette subfamily B member 11	Homo sapiens	363-367
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	174-179	ATP binding cassette subfamily C member 2	Homo sapiens	399-403
32448085-3	2021	The first step in this investigation was to solvate the isolated S-protein in water for molecular dynamics (MD) simulation, being observed a transition from "up" to "down" conformation of receptor-binding domain (RBD) of the S-protein with angle of 54.3 and 43.0 degrees, respectively.	Water	78-83	vitronectin	Homo sapiens	225-234
33313440-0	2020	Tapping Out: Influence of Organoleptic and Perceived Health Risks on Bottled Versus Municipal Tap Water Consumption Among Obese, Low Socioeconomic Status Pediatric Patients.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	0-3
33313440-3	2020	We evaluated drinking water consumption habits in a cohort of obese pediatric patients to determine the percentage that might avoid exposure to EDCs from drinking municipal tap water.	Water	177-182	nuclear RNA export factor 1	Homo sapiens	173-176
15894173-7	2005	Our results indicate that pp60(src) and Btk co-immunoprecipitate after platelet stimulation with TG+Iono, thrombin or H(2)O(2).	Water	118-123	Bruton tyrosine kinase	Homo sapiens	40-43
33313440-8	2020	"Taste" and "Health Concerns" were the most commonly endorsed reasons for eschewing tap water.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
33313440-9	2020	Bottled water consumption among low socioeconomic status patients may reduce their risk for exposure to EDCs in municipal tap water.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	122-125
33313440-9	2020	Bottled water consumption among low socioeconomic status patients may reduce their risk for exposure to EDCs in municipal tap water.	Water	126-131	nuclear RNA export factor 1	Homo sapiens	122-125
32595899-10	2020	DeltaE change was noticeable between TAP and MTAP compared to the distilled water group.	Water	76-81	methylthioadenosine phosphorylase	Homo sapiens	45-49
16050503-5	2005	Drinking non-chlorinated municipal tap water was strongly associated with illness (OR 34.4).	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
31833115-1	2020	As it forms water-filled channel in the mitochondria outer membrane and diffuses essential metabolites such as NADH and ATP, the voltage-dependent anion channel (VDAC) protein family plays a central role in all eukaryotic cells.	Water	12-17	mitochondrial outer membrane protein porin of 34 kDa	Solanum tuberosum	129-160
16137981-11	2005	By contrast, hydrotherapy with tap water resulted only in the temporary improvement of just a single parameter: the VAS score improved significantly (p &lt; 0.01).	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
16014042-9	2005	Interestingly, in oocytes injected with rBAT with or without xCT, uptake of l-cystine was significantly greater than that in water-injected oocytes.	Water	125-130	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	40-44
31833115-1	2020	As it forms water-filled channel in the mitochondria outer membrane and diffuses essential metabolites such as NADH and ATP, the voltage-dependent anion channel (VDAC) protein family plays a central role in all eukaryotic cells.	Water	12-17	mitochondrial outer membrane protein porin of 34 kDa	Solanum tuberosum	162-166
32486465-3	2020	Water superficial velocity is predicted based on pattern identification among bubble, churn, and slug flows.	Water	0-5	snail family transcriptional repressor 2	Homo sapiens	97-101
16115460-8	2005	Moreover, water deprivation, while increasing the activity of AVP neurons, reduces plasma apelin concentrations and induces an intra-neuronal pile up of the peptide, thereby decreasing the inhibitory effect of apelin on AVP release and preventing additional water loss at the kidney level.	Water	10-15	apelin	Rattus norvegicus	90-96
16115460-8	2005	Moreover, water deprivation, while increasing the activity of AVP neurons, reduces plasma apelin concentrations and induces an intra-neuronal pile up of the peptide, thereby decreasing the inhibitory effect of apelin on AVP release and preventing additional water loss at the kidney level.	Water	10-15	apelin	Rattus norvegicus	210-216
32486465-4	2020	The experimental results show that water superficial velocity can be predicted fairly accurately for bubble, churn, and slug flows with a water cut higher than 60% (absolute average percentage deviation and absolute average deviation are 4.1057% and 0.0281 m/s, respectively).	Water	35-40	snail family transcriptional repressor 2	Homo sapiens	120-124
32486465-4	2020	The experimental results show that water superficial velocity can be predicted fairly accurately for bubble, churn, and slug flows with a water cut higher than 60% (absolute average percentage deviation and absolute average deviation are 4.1057% and 0.0281 m/s, respectively).	Water	138-143	snail family transcriptional repressor 2	Homo sapiens	120-124
32486465-5	2020	The output of the electromagnetic flowmeter is unstable and invalid in slug flows with a water cut below 60% due to the non-conducting gas slug is almost filling the pipe.	Water	89-94	snail family transcriptional repressor 2	Homo sapiens	71-75
32486465-5	2020	The output of the electromagnetic flowmeter is unstable and invalid in slug flows with a water cut below 60% due to the non-conducting gas slug is almost filling the pipe.	Water	89-94	snail family transcriptional repressor 2	Homo sapiens	139-143
15701373-6	2005	Transcript levels for collagen type I (Col I), ALP, and osteopontin (OP) increased (p&lt;0.05) in the water-based silk scaffolds in comparison to the HFIP-derived materials.	Water	102-107	ATHS	Homo sapiens	47-50
32472203-0	2020	Intermolecular hydrogen bond interactions in the thiourea/water complexes (Thio-(H2O)n) (n = 1, ..., 5): X-ray, DFT, NBO, AIM, and RDG analyses.	Water	58-63	acetyl-CoA acyltransferase 1	Homo sapiens	75-79
32472203-0	2020	Intermolecular hydrogen bond interactions in the thiourea/water complexes (Thio-(H2O)n) (n = 1, ..., 5): X-ray, DFT, NBO, AIM, and RDG analyses.	Water	81-84	acetyl-CoA acyltransferase 1	Homo sapiens	75-79
15788440-6	2005	The enhanced CD4(+) T cell death with a suppressive dose of Con A is dependent on excess H(2)O(2) and nitric oxide but is independent of Fas and caspase activity.	Water	89-95	CD4 antigen	Mus musculus	13-16
32472203-2	2020	Geometry optimizations of Thio-(H2O)1-5 complexes were carried out in the gas phase by B3LYP/6-311++G(d,p) level of density functional theory.	Water	32-35	acetyl-CoA acyltransferase 1	Homo sapiens	26-30
32472203-4	2020	NBO analysis shows that the Thio-(H2O)5 complex has higher stabilization energy values than the other complexes.	Water	34-37	acetyl-CoA acyltransferase 1	Homo sapiens	28-32
15972638-2	2005	EAU-susceptible B10.RIII mice immunized with the retinal autoantigen interphotoreceptor retinoid binding protein in CFA and treated with anti-CD40L Ab (MR1) had reduced incidence and severity of disease.	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	69-112
32297623-1	2020	A water-soluble photosensitizer, PQs-PEG5, based on a novel pyrazino[2,3-g]quinoxaline (PQ) prototype compound (PQs-5), was designed and synthesized.	Water	2-7	neuronatin	Homo sapiens	37-41
16137719-8	2005	Knocking out NG2 proteoglycan on vasculogenic and angiogenic pericytes reduced interstitial fluid pressure in melanoma from +4.9 cm H2O to -0.4 cm H2O (P=0.0054 Mann-Whitney U test).	Water	132-135	chondroitin sulfate proteoglycan 4	Mus musculus	13-16
16137719-8	2005	Knocking out NG2 proteoglycan on vasculogenic and angiogenic pericytes reduced interstitial fluid pressure in melanoma from +4.9 cm H2O to -0.4 cm H2O (P=0.0054 Mann-Whitney U test).	Water	147-150	chondroitin sulfate proteoglycan 4	Mus musculus	13-16
32670175-2	2020	The majority of adult patients has serum antibodies directed against the water channel protein aquaporin 4 (AQP4-abs).	Water	73-78	aquaporin 4	Homo sapiens	108-112
16607770-1	2005	This paper describes the analytical study of a sodium chloride mineral water from Baltatesti Spa--Neamt county.	Water	71-76	surfactant protein A2	Homo sapiens	93-96
32171098-7	2020	The water uptake of both AMX and ASE was shown to be the greatest in Na2SO4 solutions.	Water	4-9	arylsulfatase L	Homo sapiens	33-36
15650134-1	2005	Aquaporin (AQP)5, an exocrine-type water channel, was detected in the rat duodenum by Western blot analysis, and was localized by immunohistochemistry in the secretory granule membranes as well as in the apical and lateral aspects of the plasma membrane of Brunner"s gland cells.	Water	35-40	aquaporin 5	Rattus norvegicus	11-16
32414133-7	2020	Tap-water samples were analyzed for the determination of metals by standard addition methodology with good accuracy, by using a low-cost and easily disposable paper-based electrochemical platform.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
15657301-4	2005	Parallel changes in V1a receptor density were observed in both strains during chronic water loading (plus approximately 50 fmol/mg) and during dehydration (minus approximately 50 fmol/mg).	Water	86-91	arginine vasopressin receptor 1A	Rattus norvegicus	20-23
15657301-7	2005	Dehydration decreased expression approximately 50% in renal vessels independent of rat strain; water loading increased V1a mRNA.	Water	95-100	arginine vasopressin receptor 1A	Rattus norvegicus	119-122
33094764-0	2020	Ion chromatography for monitoring [NTf2]- anion contaminants in pure and saline water.	Water	80-85	nuclear transport factor 2	Homo sapiens	35-39
15718385-9	2005	Conversely, significantly fewer neurons within the hindbrain dorsal vagal complex were activated in OT -/- mice after water deprivation compared with activation in wild-type mice.	Water	118-123	oxytocin	Mus musculus	100-102
32392885-1	2020	A heterometallic metal-organic framework (MOF) of [Cd6Ca4(BTB)6(HCOO)2(DEF)2(H2O)12] DEF xSol (1, H3BTB = benzene-1,3,5-tribenzoic acid; DEF = N,N"-diethylformamide; xSol.	Water	77-80	UTP25 small subunit processome component	Homo sapiens	85-88
15940115-3	2005	The application of molecular typing methods made it possible, during the last approximately 7 years, to identify ICU tap water as a significant source of exogenous P aeruginosa isolates.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
15940115-4	2005	A review of prospective studies published between 1998 and 2005 showed that between 9.7% and 68.1% of randomly taken tap water samples on different types of ICUs were positive for P aeruginosa , and between 14.2% and 50% of infection/colonization episodes in patients were due to genotypes found in ICU water.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
32321826-10	2020	We observe experimentally and predict theoretically fast reaction of syn-MVK-oxide with SO2 and formic acid, similar to smaller alkyl-substituted CIs, and by contrast, slow removal in the presence of water.	Water	200-205	synemin	Homo sapiens	69-72
15937663-6	2005	The method was successfully used for analysis of tap-water and groundwater matrices spiked at the 0.10 microg L(-1), revealing the suitability of the method for determination of pyrethroid pesticides in real samples.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
31573704-3	2020	Recent advances in 2D electrocatalysts are reviewed for emerging applications that utilize naturally existing H2 O, N2 , O2 , Cl- (seawater) and CH4 (natural gas) as reactants for nitrogen reduction (N2   NH3 ), two-electron oxygen reduction (O2   H2 O2 ), chlorine evolution (Cl-   Cl2 ), and methane partial oxidation (CH4   CH3 OH) reactions to generate NH3 , H2 O2 , Cl2 , and CH3 OH.	Water	110-114	endogenous retrovirus group W member 5	Homo sapiens	283-286
15920781-1	2005	A method for the separation by capillary zone electrophoresis and determination of vitamers of two important water-soluble vitamins, i.e., B2 and B6, is proposed here.	Water	109-114	immunoglobulin kappa variable 5-2	Homo sapiens	139-148
15527429-8	2004	Bilateral glycopyrrolate was superior to both unilateral glycopyrrolate and tap water in most patients.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
15951638-3	2005	Four house tap water samples from residents, whose contact lens storage cases had been contaminated by Acanthamoeba, were also found to be contaminated with Acanthamoeba.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
15525622-4	2004	In the control group, patients gargled with 25 mL of tap water.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
31573704-3	2020	Recent advances in 2D electrocatalysts are reviewed for emerging applications that utilize naturally existing H2 O, N2 , O2 , Cl- (seawater) and CH4 (natural gas) as reactants for nitrogen reduction (N2   NH3 ), two-electron oxygen reduction (O2   H2 O2 ), chlorine evolution (Cl-   Cl2 ), and methane partial oxidation (CH4   CH3 OH) reactions to generate NH3 , H2 O2 , Cl2 , and CH3 OH.	Water	110-114	endogenous retrovirus group W member 5	Homo sapiens	371-374
15525622-7	2004	RESULTS: Before orotracheal intubation, all 19 patients who gargled with tap water (control group) had bacterial colonization on the posterior walls of the pharynx.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
32401422-2	2020	This chloride-chloride ion-pair cluster consists of a [Cl2 (H2 O)2 ]2- square with opposite edges bridged by water molecules to give a chair-like structure of the non-hydrogen atoms.	Water	109-114	endogenous retrovirus group W member 5	Homo sapiens	55-58
15532843-9	2004	CONCLUSIONS: Health spa treatments based on consumption of waters with a high content of mineral salts seem to be capable of improving gastric emptying of solids in dyspeptics.	Water	59-65	surfactant protein A2	Homo sapiens	20-23
15557733-4	2004	This translocation enables the transepithelial reabsorption of water from the lumen to the interstitium via AQP2 at the apical membrane and AQP3/AQP4 at the basolateral membrane.	Water	63-68	aquaporin 4	Canis lupus familiaris	145-149
32182483-4	2020	A dynamic model describing biological H2S removal from sour water in the BTF/BF was developed and calibrated by a set of experimental data.	Water	60-65	BCL2 associated transcription factor 1	Homo sapiens	73-79
15487961-0	2004	Throwing out the baby with the spa water?	Water	35-40	surfactant protein A2	Homo sapiens	31-34
15883183-6	2005	p25alpha unfolds cooperatively in urea according to a simple two-state transition with a stability in water of approximately 5 kcal/mol.	Water	102-107	tubulin polymerization promoting protein	Homo sapiens	0-8
32357181-6	2020	The prolonged water deficit also led to increased relative membrane permeability and oxidative stress induced by the production of malondialdehyde (from lipid peroxidation), lipoxygenase activity (LOX) and the production of H2O2.	Water	14-19	linoleate 9S-lipoxygenase4	Zea mays	174-186
16180766-3	2005	Owing to the lack of sufficient water resource from the upper reaches of Heihe River, a series of ecological and environmental problems are getting more serious in the oasis in recent years.	Water	32-37	cAMP responsive element binding protein 3 like 1	Homo sapiens	168-173
15280382-4	2004	Depletion of Prx III resulted in increased intracellular levels of H(2)O(2) and sensitized cells to induction of apoptosis by staurosporine or TNF-alpha.	Water	67-72	peroxiredoxin 3	Homo sapiens	13-20
32693901-0	2020	[Simultaneous determination of 16 polycyclic aromatic hydrocarbons in source water and tap water by performance liquid chromatography with ultraviolet detector tandem fluorescence detector combined with solid phase extraction].	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
15482567-1	2004	The expression of aquaporin-5, the major water channel expressed in alveolar, tracheal, and upper bronchial epithelium, is significantly down-regulated during acute lung injury.	Water	41-46	aquaporin 5	Mus musculus	18-29
15941051-2	2005	This method makes it possible to quantify 0.3 microg/l of polycarbamate in tap water, which is a 1/100 of the residual target value of 30 microg/l in Japan.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
16852085-11	2005	A hydrogen bond is frequently formed between the 5"-OH group and the syn bases, despite competition by water.	Water	103-108	synemin	Homo sapiens	69-72
32693901-1	2020	OBJECTIVE: To establish a rapid method for simultaneous determination of 16 polycyclic aromatic hydrocarbons(PAHs) in source water and tap water by performance liquid chromatography(HPLC) with ultraviolet detector(UV) tandem fluorescence detector(FLR).	Water	139-144	nuclear RNA export factor 1	Homo sapiens	135-138
15243686-11	2004	P. aeruginosa was isolated from the room"s tap water in 62.4% of samples.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
32693901-2	2020	METHODS: Source water was filtered by GF/C glass fiber filters and tap water were added ascorbic acid of 60 mg per liter to remove the residual chlorine when sampling.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
15243686-12	2004	More than 90% of tap water samples had pulsotypes 1 and 2, which were frequently isolated in the stomach (59%) but were only rarely associated with VAP.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
15550556-0	2005	Water and enzyme secretion are tightly coupled in pancreatic secretion stimulated by food or CCK-58 but not by CCK-8.	Water	0-5	cholecystokinin	Rattus norvegicus	93-96
32693901-21	2020	Then the established method was used for the determination of 17 water samples, 8 kinds, 6 kinds and 7 kinds of PAHs were detected in source water, tap water and pipe net tap water, respectively.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	148-151
15550556-5	2005	This pattern of secretion was reproduced by intravenous infusion of the CCK-58 form of cholecystokinin, which strongly stimulates pancreatic water and chloride secretion, but not by CCK-8, which only weakly stimulates water and chloride secretion in a non-dose-dependent manner.	Water	141-146	cholecystokinin	Rattus norvegicus	72-75
32693901-21	2020	Then the established method was used for the determination of 17 water samples, 8 kinds, 6 kinds and 7 kinds of PAHs were detected in source water, tap water and pipe net tap water, respectively.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	171-174
15388805-5	2004	A significant increase in DNA migration was observed in both cell types after 1 h treatment with filtered and tap water, and, to a lesser extent, chlorine dioxide pre-disinfected water.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	110-113
32693901-22	2020	CONCLUSION: The method is rapid, sensitive and selective, and has been successfully applied for determination of 16 PAHs in source water and tap water.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
15388805-7	2004	Overloading of the carbon filter, with a consequent peak release, might explain the high genotoxicity found in water samples C and D. Cell toxicity and DNA damage increases were also detected in metabolically competent HepG2 cells treated with a lower concentration of tap water extract for a longer exposure time (24 h).	Water	273-278	nuclear RNA export factor 1	Homo sapiens	269-272
16001369-4	2005	An optimal water treatment system should include tap water pre-treatment and a double reverse osmosis process.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	49-52
32701494-8	2020	Furthermore, this method exhibited good feasibility in tap water and lake water.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
16001369-9	2005	Treated tap water used to prepare dialysis fluid should be within European Pharmacopoeia limits at the water treatment system inlet and at the reverse osmosis outlet.	Water	12-17	nuclear RNA export factor 1	Homo sapiens	8-11
16001369-9	2005	Treated tap water used to prepare dialysis fluid should be within European Pharmacopoeia limits at the water treatment system inlet and at the reverse osmosis outlet.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	8-11
15276331-8	2004	The treatment of water frogs with the herbicide dichlobenil decreased both the above-mentioned activities and the immunoreactive CYP2A apoprotein.	Water	17-22	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	129-134
32365630-5	2020	Binding of gallacetophenone to the active site of tyrosinase was found to be stabilized by hydrophobic interactions with His367, Ile368, and Val377; hydrogen bonding with Ser380 and a water molecule bridging the copper ions.	Water	184-189	tyrosinase	Homo sapiens	50-60
15208268-1	2004	Aquaporin-4 (AQP4) is the major water channel in the brain, expressed predominantly in astroglial cell membranes.	Water	32-37	aquaporin 4	Mus musculus	0-11
15208268-1	2004	Aquaporin-4 (AQP4) is the major water channel in the brain, expressed predominantly in astroglial cell membranes.	Water	32-37	aquaporin 4	Mus musculus	13-17
15208268-8	2004	Thus, AQP4-mediated transcellular water movement is crucial for fluid clearance in vasogenic brain edema, suggesting AQP4 activation and/or up-regulation as a novel therapeutic option in vasogenic brain edema.	Water	34-39	aquaporin 4	Mus musculus	6-10
15208268-8	2004	Thus, AQP4-mediated transcellular water movement is crucial for fluid clearance in vasogenic brain edema, suggesting AQP4 activation and/or up-regulation as a novel therapeutic option in vasogenic brain edema.	Water	34-39	aquaporin 4	Mus musculus	117-121
15223068-7	2004	These results indicate that CaM-dependent one-electron reduction of TNT is catalyzed by nNOS, leading to a reduction in NO formation and generation of H(2)O(2) derived from O(2)(.-).	Water	151-156	nitric oxide synthase 1	Rattus norvegicus	88-92
15781442-5	2005	The AOX inhibitor salicylhydroxamic acid (1 mM; SHAM) inhibited 70% of AOX activity in vivo in both water-replete and drought-exposed plants.	Water	100-105	ubiquinol oxidase 1a, mitochondrial	Triticum aestivum	4-7
15781442-5	2005	The AOX inhibitor salicylhydroxamic acid (1 mM; SHAM) inhibited 70% of AOX activity in vivo in both water-replete and drought-exposed plants.	Water	100-105	ubiquinol oxidase 1a, mitochondrial	Triticum aestivum	71-74
15924307-5	2005	Application to the analysis of fortified tap water samples yielded good recovery values (91-103%, according to the herbicide).	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
32227839-3	2020	The rigidity of the fused ring structure and absence of mobile methyl groups increase the spin echo dephasing time (Tm) at temperatures above 80 K. This enables DEER measurements of distances >4 nm in DZD labeled-T4L in glycerol/water at temperatures up to 150 K, with increased sensitivity compared to common spin label such as MTSL.	Water	229-234	spindlin 1	Homo sapiens	90-94
15493459-8	2004	Our results demonstrate that ascorbic acid is rapidly oxidized to dehydroascorbic acid and further decomposed to oxalic- and threonic acid in copper contaminated household tap water that is buffered with bicarbonate.	Water	176-181	nuclear RNA export factor 1	Homo sapiens	172-175
32227848-1	2020	Threshold collision-induced dissociation (TCID) of Th(OH)3+(H2O)n (n = 1 - 4) with xenon was performed using a guided ion beam tandem mass spectrometer (GIBMS).	Water	60-63	SS nuclear autoantigen 1	Homo sapiens	67-76
32133758-6	2020	The O5 and O6/Ox groups were proposed to be substrate water derived species.	Water	54-59	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	11-16
15381006-1	2004	The polysaccharide isolated from the gum exudate of palm Scheelea phalerata (SPN) was water-insoluble and composed of Fuc, Ara, Xyl, and uronic acid moieties in a 5:34:54:7 molar ratio: 12% of phenolics were also present.	Water	86-91	DEAF1 transcription factor	Homo sapiens	77-80
16134575-2	2005	The article summarizes the literature on the dynamics of tap water lead contamination and discusses this widespread source of lead exposure in the context of the latest research evidence.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
15197742-3	2004	After injection of Abeta, the spatial memory of rats was significantly impaired in the Morris water maze.	Water	94-99	amyloid beta precursor protein	Rattus norvegicus	19-24
15951854-12	2005	Whether in patients or normal subjects, drinking hard water should be avoided; tap water or low calcium content water is preferable.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
32297013-0	2020	Assessing water distribution and agricultural expansion in the Cele Oasis, China.	Water	10-15	cAMP responsive element binding protein 3 like 1	Homo sapiens	68-73
15951854-12	2005	Whether in patients or normal subjects, drinking hard water should be avoided; tap water or low calcium content water is preferable.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
15250227-10	2004	CPAP pressure selected with conventional or daytime manual titration (7.5(2.2) cm H2O and 7.4(1.5) cm H2O, ns) were significantly lower (P&lt; 0.001) than with AutoSet (9.4(1.6) cm H20.	Water	82-85	centromere protein J	Homo sapiens	0-4
32297013-2	2020	Oases" dependency on water availability from mountainous regions plays a critical factor in the sustainability of agricultural practices and oasis expansion.	Water	21-26	cAMP responsive element binding protein 3 like 1	Homo sapiens	141-146
15250227-10	2004	CPAP pressure selected with conventional or daytime manual titration (7.5(2.2) cm H2O and 7.4(1.5) cm H2O, ns) were significantly lower (P&lt; 0.001) than with AutoSet (9.4(1.6) cm H20.	Water	102-105	centromere protein J	Homo sapiens	0-4
15695511-1	2005	The astroglial water channel aquaporin-4 (AQP4) facilitates water movement into and out of brain parenchyma.	Water	15-20	aquaporin 4	Mus musculus	29-40
15695511-1	2005	The astroglial water channel aquaporin-4 (AQP4) facilitates water movement into and out of brain parenchyma.	Water	15-20	aquaporin 4	Mus musculus	42-46
32297013-4	2020	With over 97% of Cele"s economy tied to agriculture, unfettered expansion of the oasis into the desert has raised concern on water availability.	Water	125-130	cAMP responsive element binding protein 3 like 1	Homo sapiens	81-86
15695511-1	2005	The astroglial water channel aquaporin-4 (AQP4) facilitates water movement into and out of brain parenchyma.	Water	60-65	aquaporin 4	Mus musculus	29-40
32112918-9	2020	HDAC10 silencing aggravated ICH injury, as demonstrated by increased modified neurological severity scores, brain water content, Evans blue extravasation, and number of myeloperoxidase (MPO) cells, and the results of Nissl and H&E staining.	Water	114-119	histone deacetylase 10	Rattus norvegicus	0-6
15695511-1	2005	The astroglial water channel aquaporin-4 (AQP4) facilitates water movement into and out of brain parenchyma.	Water	60-65	aquaporin 4	Mus musculus	42-46
15695511-3	2005	AQP4-deficient mice had remarkably lower intracranial pressure (9 +/- 1 versus 25 +/- 5 cm H2O) and brain water accumulation (2 +/- 1 versus 9 +/- 1 microl) at 30 h, and improved survival (80 versus 0% survival) at 60 h, through comparable CSF bacterial and white cell counts.	Water	91-94	aquaporin 4	Mus musculus	0-4
15695511-3	2005	AQP4-deficient mice had remarkably lower intracranial pressure (9 +/- 1 versus 25 +/- 5 cm H2O) and brain water accumulation (2 +/- 1 versus 9 +/- 1 microl) at 30 h, and improved survival (80 versus 0% survival) at 60 h, through comparable CSF bacterial and white cell counts.	Water	106-111	aquaporin 4	Mus musculus	0-4
15695511-5	2005	AQP4 protein was strongly up-regulated in meningitis, resulting in a approximately 5-fold higher water permeability (P(f)) across the blood-brain barrier compared with non-infected wild type mice.	Water	97-102	aquaporin 4	Mus musculus	0-4
15186161-6	2004	The study also suggests that the wild-type GB1p sequence is significantly less stable than reported in some other studies: only 30% folded in water at 25 degrees C.	Water	142-147	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	43-47
32351550-1	2020	1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO3}n (1), {[Ag(bpa)2]CF3SO3 .H2O}n (2) and {[Ag(bpe)]CF3SO3}n (3).	Water	170-173	Bis protein	Escherichia coli	4-7
15110934-2	2004	Using the synchrotron small-angle X-ray diffraction (SAXD), it is shown that the C3A anesthetic induces the cubic and hexagonal (H(I)) phases at 2 &gt; or = C3A:EYPC &gt; 0.5 and H2O:EYPC &lt; or = 40 molar ratios.	Water	179-182	complement C3	Homo sapiens	81-84
15880964-7	2005	The mean (+/- SD) fluoride content for all tap water was 0.20 +/- 0.17 microg F/g (ranging from 0.01 to 0.88 microg F/g) and 0.24 +/- 0.24 microg F/g for all bottled water (ranging from 0.01 to 2.80 microg F/g).	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
15880964-14	2005	Monitoring of fluoride content of both bottled and tap water is strongly advised.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
15264022-4	2004	In this study we demonstrate that the Stx2 B subunit inhibits the water absorption (Jw) across the human and rat colonic mucosa without altering the electrical parameters measured as transepithelial potential difference and short circuit current.	Water	66-71	syntaxin 2	Homo sapiens	38-44
32351550-1	2020	1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO3}n (1), {[Ag(bpa)2]CF3SO3 .H2O}n (2) and {[Ag(bpe)]CF3SO3}n (3).	Water	170-173	Bis protein	Escherichia coli	39-42
32126844-3	2020	Several methods were used to validate the formation of RHPC and RHPC-MD, such as differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, infrared spectroscopy, particle size, and zeta potential, meanwhile, their octanol-water partition coefficient, solubility, and dissolution in vitro were also evaluated.	Water	282-287	Rh blood group, D antigen	Rattus norvegicus	55-59
14769833-2	2004	Injection of N-methyl-D-aspartate (NMDA; 18-20 nmol) into the CA1 region of the left hippocampus resulted in significant brain edema as measured by the percentage of total forebrain water content that occurred 24 h after intrahippocampal microinjection of NMDA with approximately 50% loss of CA1 neurons assessed 72 h later.	Water	182-187	carbonic anhydrase 1	Homo sapiens	62-65
16036307-3	2005	The purpose of this study is to investigate the potential of water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (Dox) conjugates containing a Hsp47/CBP2 binding peptide sequence, namely WHYPWFQNWAMA for targeted delivery to SCCHN.	Water	61-66	serpin family H member 1	Homo sapiens	168-173
15259657-7	2004	The results indicate the CS-1 seeds have a dose-rate constant of 0.915 cGy hr(-1) U(-1) in water, dose penetration characteristics similar to 125I and 103Pd, anisotropy function values on the order of 0.71 at short distances and small angles, and an average anisotropy factor of 0.964.	Water	91-96	chorionic somatomammotropin hormone 1	Homo sapiens	25-29
32044663-3	2020	METHODS: EAU was induced in B10R.III mice by immunization with IRBP 161-180, followed by 100 mg/kg/d BBR intragastric administration.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	63-67
15203244-0	2004	Assessment of ethanol consumption and water drinking by NPY Y(2) receptor knockout mice.	Water	38-43	neuropeptide Y receptor Y2	Mus musculus	56-73
16036307-3	2005	The purpose of this study is to investigate the potential of water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (Dox) conjugates containing a Hsp47/CBP2 binding peptide sequence, namely WHYPWFQNWAMA for targeted delivery to SCCHN.	Water	61-66	serpin family H member 1	Homo sapiens	174-178
16833602-6	2005	The production of Cl2 is found only in the gamma-radiolysis of CaCl2 with a few weight percent of excess water.	Water	105-110	endogenous retrovirus group W member 5	Homo sapiens	18-21
32044663-16	2020	CONCLUSIONS: BBR inhibited IRBP induced EAU, which was associated with a significant change in the spleen transcriptome and intestinal microbial composition.	Water	40-43	retinol binding protein 3, interstitial	Mus musculus	27-31
32296436-3	2020	This results in the formation of non-proteolytically activated C3(H2O) which is believed have C3b-like properties and be able to form an active initial fluid phase C3 convertase together with Factor B (FB).	Water	66-69	complement C3	Homo sapiens	94-97
15752492-1	2005	In Thailand, surface water and groundwater are the main water sources for tap water and drinking water production.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	74-77
15752492-1	2005	In Thailand, surface water and groundwater are the main water sources for tap water and drinking water production.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	74-77
15752492-1	2005	In Thailand, surface water and groundwater are the main water sources for tap water and drinking water production.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	74-77
15752492-6	2005	The concentration of disinfection by-products was higher in tap water produced from Chao Praya river than from Mae Klong river.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
15082403-0	2004	Positive cooperativity in substrate binding of human prostatic acid phosphatase entrapped in AOT-isooctane-water reverse micelles.	Water	107-112	acid phosphatase 3	Homo sapiens	53-79
15082403-1	2004	The kinetics of 1-naphthyl phosphate and phenyl phosphate hydrolysis, catalyzed by human prostatic acid phosphatase (PAP) entrapped in AOT-isooctane-water reverse micelles, has been studied over surfactant hydration degree (w0) range 5 to 35.	Water	149-154	acid phosphatase 3	Homo sapiens	89-115
15131626-15	2004	Changes in the sources of water meant that less water consumed was likely to come from the tap in the house and more from drinks made elsewhere, than 20 years previously.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	91-94
15131626-15	2004	Changes in the sources of water meant that less water consumed was likely to come from the tap in the house and more from drinks made elsewhere, than 20 years previously.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	91-94
16701792-3	2005	We present a simple approach for synthesizing elastin-based materials from two commercially available and water-soluble components: alpha-elastin and a diepoxy crosslinker.	Water	106-111	elastin	Homo sapiens	46-53
32124930-8	2020	Our results confirmed that adding of 15ppm GNPs in drinking water were induced remarkable blood oxidative stress damage, histopathological alterations, up-regulation of IL-6, Nrf2 gene expression, and DNA fragmentation in the examined immune organs of the broiler chickens as well as a significant reduction in the antibody titer against Newcastle (ND) and avian influenza (AI) viruses were noticed.	Water	60-65	interleukin 6	Gallus gallus	169-173
15790122-2	2005	The method proved to be applicable to different kinds of water samples used in the experiment and tap-water samples from different suppliers.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
15790122-7	2005	For ice of tap water, which contained relatively higher amount of cations, the TSDC profiles were quite different in shape compared with the standard ice-water samples (shift of peaks A - D to higher temperature, and a strong increase in the current strength of peaks B - E).	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
15132687-0	2004	Effect of water on the molecular mobility of elastin.	Water	10-15	elastin	Homo sapiens	45-52
32245028-1	2020	Water use efficiency in agriculture can be improved by implementing advisory systems that support on-farm irrigation scheduling, with reliable forecasts of the actual crop water requirements, where crop evapotranspiration (ETc) is the main component.	Water	0-5	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	167-171
15161151-6	2004	However, as River Sink discharge rates peaked following three rainfall events during the study period, the conduit system lost water, presumably into the matrix.	Water	127-132	tribbles pseudokinase 3	Homo sapiens	18-22
15145587-16	2004	It is also clear that consumers" regularly consume more than 500 HPC/ml from drinking water taken from the household tap.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	117-120
15710470-2	2005	At 8 h, cerebrospinal fluid (CSF) VEGF was significantly elevated in infected untreated animals, and correlated with CSF white blood cell (WBC) count (r=0.56, P=0.004), and brain water content (r=0.42, P=0.04).	Water	179-184	vascular endothelial growth factor A	Oryctolagus cuniculus	34-38
32245028-1	2020	Water use efficiency in agriculture can be improved by implementing advisory systems that support on-farm irrigation scheduling, with reliable forecasts of the actual crop water requirements, where crop evapotranspiration (ETc) is the main component.	Water	0-5	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	198-202
15740765-0	2005	Multi-route trihalomethane exposure in households using municipal tap water treated with chlorine or ozone-chlorine.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
32043350-6	2020	Afterwards, glucose oxidase (GOx) in nanocatalysts could consume glucose in tumor microenvironment (TME), and in situ synchronously produce H2O2 which could improve Fenton reaction efficiency.	Water	140-144	hydroxyacid oxidase 1	Homo sapiens	12-27
15225806-5	2004	Mice lacking the Vitamin D receptor (VDR) have elevated production of renin and angiotensin (Ang) II, leading to hypertension, cardiac hypertrophy and increased water intake.	Water	161-166	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	17-35
15225806-5	2004	Mice lacking the Vitamin D receptor (VDR) have elevated production of renin and angiotensin (Ang) II, leading to hypertension, cardiac hypertrophy and increased water intake.	Water	161-166	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	37-40
15740765-4	2005	Similar to previous findings, the winter chloroform concentration in tap water treated with chlorine (22.1 microg/l, median) was significantly higher than that in the tap water treated with ozone-chlorine (16.8 microg/l, median).	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
32043350-6	2020	Afterwards, glucose oxidase (GOx) in nanocatalysts could consume glucose in tumor microenvironment (TME), and in situ synchronously produce H2O2 which could improve Fenton reaction efficiency.	Water	140-144	hydroxyacid oxidase 1	Homo sapiens	29-32
15740765-4	2005	Similar to previous findings, the winter chloroform concentration in tap water treated with chlorine (22.1 microg/l, median) was significantly higher than that in the tap water treated with ozone-chlorine (16.8 microg/l, median).	Water	171-176	nuclear RNA export factor 1	Homo sapiens	167-170
15016730-7	2004	beta1AR-/-/beta2AR-/- and beta1AR+/+/beta2AR-/- mice had more lung water and worse survival from this form of acute lung injury than wild-type controls.	Water	67-72	adrenergic receptor, beta 1	Mus musculus	0-7
15016730-7	2004	beta1AR-/-/beta2AR-/- and beta1AR+/+/beta2AR-/- mice had more lung water and worse survival from this form of acute lung injury than wild-type controls.	Water	67-72	adrenergic receptor, beta 1	Mus musculus	26-33
31991338-1	2020	Cancer starvation therapy based on catalytic chemistry of glucose oxidase (GOx) offers great potential for multimodal treatment, benefiting from both nutrition shutting-off and the oxidization product hydrogen peroxide (H2O2).	Water	220-224	hydroxyacid oxidase 1	Homo sapiens	58-73
15117067-10	2004	The tap water samples analyzed contain variable concentrations of the four trihalomethanes, ranging from 1.0 to 66.5 microg l(-1), depending of the compound.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
15733317-4	2005	METHODS: In the current analysis, we constructed a personal delivered dose (PDD) model that included personal information on tap water consumption and bathing habits so that inhalation, ingestion, and dermal absorption were also considered.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
18969883-0	2005	Preconcentration and determination of ultra trace amounts of arsenic(III) and arsenic(V) in tap water and total arsenic in biological samples by cloud point extraction and electrothermal atomic absorption spectrometry.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
31991338-1	2020	Cancer starvation therapy based on catalytic chemistry of glucose oxidase (GOx) offers great potential for multimodal treatment, benefiting from both nutrition shutting-off and the oxidization product hydrogen peroxide (H2O2).	Water	220-224	hydroxyacid oxidase 1	Homo sapiens	75-78
18969883-11	2005	The method was successfully applied to the determination of As(III) and As(V) in tap water and total arsenic in biological samples (hair and nail).	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
31991338-3	2020	The cascade began when GOx was delivered into tumor sites through homotypic targeting, facilitating selective starving of cancer cells and H2O2 generation.	Water	139-143	hydroxyacid oxidase 1	Homo sapiens	23-26
15065850-1	2004	trans-3-Chloroacrylic acid dehalogenase (CaaD) converts trans-3-chloroacrylic acid to malonate semialdehyde by the addition of H(2)O to the C-2, C-3 double bond, followed by the loss of HCl from the C-3 position.	Water	127-132	complement C3	Homo sapiens	145-148
32476731-4	2020	The increasing close contact between animals and humans in both work and living environments creates hot spots in peri-urban areas, thereby increasing vulnerability to zoonotic disease transmission and other health hazards associated with food safety, water, and sanitation-related diseases.	Water	252-257	perilipin 1	Homo sapiens	114-118
15065850-1	2004	trans-3-Chloroacrylic acid dehalogenase (CaaD) converts trans-3-chloroacrylic acid to malonate semialdehyde by the addition of H(2)O to the C-2, C-3 double bond, followed by the loss of HCl from the C-3 position.	Water	127-132	complement C3	Homo sapiens	199-202
15031714-1	2004	PsbP is a membrane-extrinsic subunit of the water-oxidizing complex photosystem II (PS II).	Water	44-49	oxygen-evolving enhancer protein 2-2, chloroplastic	Nicotiana tabacum	0-4
15782974-8	2005	The quantitation limits of these compounds ranged from 1.0 to 8.0 ng/l in 500 ml tap water samples.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
15743240-4	2005	The observations, together with Monte Carlo simulations and density functional theory calculations, corroborate the notion for the formation of a distorted pentagonal dodecahedral (5(12)) cage with a H2O molecule in the cage and a H3O+ ion on the surface for this "magic number" water cluster ion.	Water	200-203	H3 clustered histone 15	Homo sapiens	231-234
31917868-4	2020	We demonstrated that TRPM2 is expressed in the plasma membrane of mouse pancreatic acinar and ductal cells, which can be activated by increased oxidative stress induced by H2 O2 treatment and contributed to bile acid-induced extracellular Ca2+ influx in acinar cells, which promoted acinar cell necrosis in vitro and in vivo.	Water	172-177	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	21-26
15743240-4	2005	The observations, together with Monte Carlo simulations and density functional theory calculations, corroborate the notion for the formation of a distorted pentagonal dodecahedral (5(12)) cage with a H2O molecule in the cage and a H3O+ ion on the surface for this "magic number" water cluster ion.	Water	279-284	H3 clustered histone 15	Homo sapiens	231-234
15672205-3	2005	Reaction of 4 with AgOTf/H2O yields the tris-aqua complex [Ru(d(t)bpe)(CO)(H2O)3](OTf)2 (8), which has been structurally characterised and probed in solution by pulsed-gradient spin echo (PGSE) NMR spectroscopy.	Water	25-28	POU class 2 homeobox 2	Homo sapiens	82-87
15672205-4	2005	The water ligands in 8 are labile and easily substituted to give [Ru(d(t)bpe)(CO)(NCCH3)3](OTf)2 (10) and [Ru(d(t)bpe)(CO)(DMSO)3](OTf)2 (11).	Water	4-9	POU class 2 homeobox 2	Homo sapiens	91-96
15074609-8	2004	The majority of the tap water samples, collected from areas along the seashore contained increased concentrations of chloride ions, which is a clear indication of seawater intrusion into the related aquifers.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
31917868-11	2020	Here we found that TRPM2 is expressed in the plasma membrane of mouse pancreatic acinar and ductal cells, which can be activated by increased oxidative stress induced by H2 O2 treatment.	Water	170-175	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	19-24
15672205-4	2005	The water ligands in 8 are labile and easily substituted to give [Ru(d(t)bpe)(CO)(NCCH3)3](OTf)2 (10) and [Ru(d(t)bpe)(CO)(DMSO)3](OTf)2 (11).	Water	4-9	POU class 2 homeobox 2	Homo sapiens	131-136
15679399-6	2005	AU-I, [C4N2H14][Zn(HPO4)2].H2O, crystallizes in the triclinic space group P-1, a = 8.215(2), b = 8.810(3), c = 8.861(3) A, alpha = 88.001(4) degrees , beta = 89.818(5) degrees , and gamma = 89.773(5) degrees , Z = 2.	Water	27-30	crystallin gamma F, pseudogene	Homo sapiens	74-77
31932725-3	2020	We engineered LOXCAT, a fusion of bacterial lactate oxidase (LOX) and catalase (CAT), which irreversibly converts lactate and oxygen to pyruvate and water.	Water	149-154	lysyl oxidase	Homo sapiens	14-17
32085534-0	2020	Evolution of Groundwater in Yinchuan Oasis at the Upper Reaches of the Yellow River after Water-Saving Transformation and Its Driving Factors.	Water	90-95	cAMP responsive element binding protein 3 like 1	Homo sapiens	37-42
32085534-1	2020	In recent years, the amount of water diverted from the Yellow River has been decreasing year by year, which is the biggest problem for the development and utilization of water resources in Yinchuan Oasis (YCO).	Water	31-36	cAMP responsive element binding protein 3 like 1	Homo sapiens	198-203
15498883-4	2005	Cyp24a1-null mice showed difficulty in eliminating [1beta-3H]1alpha,25(OH)2D3 from the bloodstream and tissues over a 96-h time course, whereas heterozygotic mice eliminated the hormone within 6-12 h, although there was clearance of labeled hormone into water-soluble products involving liver in both genotypes.	Water	254-259	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	0-7
32085534-1	2020	In recent years, the amount of water diverted from the Yellow River has been decreasing year by year, which is the biggest problem for the development and utilization of water resources in Yinchuan Oasis (YCO).	Water	170-175	cAMP responsive element binding protein 3 like 1	Homo sapiens	198-203
32059723-15	2020	In addition, DHYZ inhibited the phosphorylation of ASK1, JNK1/2/3 and p38 MAPK which were up-regulated by H2O2.	Water	106-110	mitogen activated protein kinase 10	Rattus norvegicus	57-65
15677340-2	2005	Because women who develop eclampsia are in general normotensive and asymptomatic prior to pregnancy, we hypothesized that pregnancy alone predisposes the brain to edema formation by up-regulation of aquaporin 4 (AQP4), a water channel in the brain that has been shown to positively correlate with edema formation.	Water	221-226	aquaporin 4	Homo sapiens	212-216
32046059-1	2020	The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.	Water	178-183	aquaporin 4	Mus musculus	26-37
15691343-10	2005	RESULTS: The use of CHX and ASF resulted in a BT of 8.4+/-4.4 mum and 15.7+/-9.9 compared with 76.7+/-29.4 mum using water.	Water	117-122	arylsulfatase F	Homo sapiens	28-31
32046059-1	2020	The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.	Water	178-183	aquaporin 4	Mus musculus	39-43
32046059-2	2020	While AQP4 is mainly involved in water flux across the astrocytic endfeet membranes, astrocytic gap junctions provide syncytial coupling allowing intercellular exchange of water, ions, and other molecules.	Water	33-38	aquaporin 4	Mus musculus	6-10
15732619-1	2005	UNLABELLED: This article reviews a study, published in Clinical and Laboratory Haematology (2003), which looked at using iron-rich spa water (Spatone) as a prophylaxis against iron deficiency in pregnancy.	Water	135-140	surfactant protein A2	Homo sapiens	131-134
32019602-8	2020	During immersion, tap water or CO2 water was stirred slowly with a pump.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
15657133-0	2005	Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus.	Water	56-61	aquaporin 4	Homo sapiens	21-32
32019602-12	2020	RESULTS: Skin blood flow of the immersed forearms was higher in CO2 water than in tap water during immersion.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
15657133-2	2005	Experimental studies have shown that clearance of extracellular K+ is compromised by removal of the perivascular pool of the water channel aquaporin 4 (AQP4), suggesting that an efficient clearance of K+ depends on a concomitant water flux through astrocyte membranes.	Water	125-130	aquaporin 4	Homo sapiens	139-150
15657133-2	2005	Experimental studies have shown that clearance of extracellular K+ is compromised by removal of the perivascular pool of the water channel aquaporin 4 (AQP4), suggesting that an efficient clearance of K+ depends on a concomitant water flux through astrocyte membranes.	Water	125-130	aquaporin 4	Homo sapiens	152-156
32019602-13	2020	The blood flow in the last 5 min (average at rest was 100%) was significantly higher in CO2 water (290.85 +- 84.81%) than in tap water (104.80 +- 21.99%).	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
15657133-9	2005	We postulate that the loss of perivascular AQP4 in MTLE is likely to result in a perturbed flux of water through astrocytes leading to an impaired buffering of extracellular K+ and an increased propensity for seizures.	Water	99-104	aquaporin 4	Homo sapiens	43-47
32019602-15	2020	Ear canal temperature significantly declined more in CO2 water (- 0.56 +- 0.31  C) than in tap water (- 0.48 +- 0.30  C) during immersion.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
32117873-3	2020	Owing to the highly hydrophobic property and protection of PMMA, PMMA-LiBH4/GMF demonstrates outstanding water-resistance and air-stability.	Water	105-110	glia maturation factor beta	Homo sapiens	76-79
15618890-1	2005	Muller glial cells of the sensory retina mediate K+ and water fluxes that are facilitated by aquaporin-4 (AQP4) water channels and by Kir4.1-K+ channels.	Water	56-61	aquaporin 4	Homo sapiens	93-104
15618890-1	2005	Muller glial cells of the sensory retina mediate K+ and water fluxes that are facilitated by aquaporin-4 (AQP4) water channels and by Kir4.1-K+ channels.	Water	56-61	aquaporin 4	Homo sapiens	106-110
15618890-1	2005	Muller glial cells of the sensory retina mediate K+ and water fluxes that are facilitated by aquaporin-4 (AQP4) water channels and by Kir4.1-K+ channels.	Water	112-117	aquaporin 4	Homo sapiens	93-104
15618890-1	2005	Muller glial cells of the sensory retina mediate K+ and water fluxes that are facilitated by aquaporin-4 (AQP4) water channels and by Kir4.1-K+ channels.	Water	112-117	aquaporin 4	Homo sapiens	106-110
32117873-5	2020	It"s our belief that the flexible, water-resistant and air-stable PMMA-LiBH4/GMF with a simple preparation route will provide a new avenue to the research of hydrogen storage materials.	Water	35-40	glia maturation factor beta	Homo sapiens	77-80
15620895-7	2005	The method was applied to the determination of nitrite in tap water, waste water, and human urine samples.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
31743528-11	2020	Silencing of lncRNA XIST reversed the effect of H2 O2 on miR-124,BACE1 and Abeta1-42 expressionin N2a cells, which was reversed by cotransfection of AMO-124.	Water	48-53	inactive X specific transcripts	Mus musculus	20-24
16851014-7	2005	(iv) Concentrated solutions of UO(2)L(2)(TBP) complexes at the CO(2)-water interface display an equilibrium between adsorbed and extracted species, and the proportion of extracted species is larger with F- than with H- ligands, in agreement with experimental observations.	Water	69-74	TATA-box binding protein	Homo sapiens	41-44
16581373-5	2005	The second study discusses a 2-ns simulation of bovine pancreatic trypsin inhibitor (BPTI) in water using a variety of fixed charge and polarizable models for both the protein and the solvent, analyzing observed root mean square deviations (RMSD), intraprotein hydrogen bonding, and water structure and dynamics.	Water	94-99	spleen trypsin inhibitor I	Bos taurus	48-83
31708174-5	2020	Bromate was found in almost all tap water samples with a mean concentration of 19.6 mug/L, which is higher than the maximum acceptable contaminant level (MCL) of 10 mug/L.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
31708174-6	2020	The mean concentration of bromide in tap water samples was 46.2 mug/L.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
31708174-11	2020	The excess cancer risk due to ingestion of bromate in tap water was estimated to be 3.92 x 10-4, which is approximately one order of magnitude higher than the maximum acceptable level of risk (2x 10-5).	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
15928416-1	2005	PURPOSE: Porins are outer membrane protein (OMP) that form water filled channels that permit the diffusion of small hydrophilic solutes like beta-lactam antibiotics across the outer membrane.	Water	59-64	outer membrane protein	Escherichia coli	20-42
31857233-1	2020	GPx8 is a glutathione peroxidase homolog inserted in the membranes of endoplasmic reticulum (ER), where it seemingly plays a role in controlling redox status by preventing the spill of H2O2.	Water	185-189	glutathione peroxidase 8 (putative)	Homo sapiens	0-4
15928416-1	2005	PURPOSE: Porins are outer membrane protein (OMP) that form water filled channels that permit the diffusion of small hydrophilic solutes like beta-lactam antibiotics across the outer membrane.	Water	59-64	outer membrane protein	Escherichia coli	44-47
31150554-4	2020	At test, during CS presentations, DN-DISC1-PrP mice consumed more water and displayed a licking profile that is more typically revealed while ingesting a sweet-tasting solution.	Water	66-71	disrupted in schizophrenia 1	Mus musculus	37-42
15663308-14	2005	It was interesting to note that the removal efficiency was even better for tap water and much better for wastewater when compared to that using distilled water.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
31150554-5	2020	DN-DISC1-PrP mice also displayed greater c-fos expression in the insular (gustatory) cortex when consuming water in the presence of the CS.	Water	107-112	disrupted in schizophrenia 1	Mus musculus	3-8
33297722-2	2020	Translational data indicate perturbed expression of astrocytic molecules contributing to homeostatic neuronal excitability, including water channels (AQP4) and synaptic glutamate transporters (EAAT2), in a mouse model of MS with seizures (MS+S).	Water	134-139	aquaporin 4	Mus musculus	150-154
15887563-0	2005	Development of a method for the concentration and recovery of microsporidia from tap water.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
15887563-4	2005	This study details method development for the detection of microsporidia in tap water.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
15887563-10	2005	Percent recoveries for 10 L tap water samples (n = 5) using the Envirocheck sampling capsule without a density gradient purification step were 26.1+/-13.4 compared to 25+/-13.8 for samples subjected to a density gradient purification step.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
31918396-4	2020	Neuroprotective activity of MT-6 has been examined against H2O2 induced toxicity in SHSY-5Y cells and they have shown effective neuroprotection.	Water	59-63	protease, serine 33	Mus musculus	28-32
15639021-0	2005	[WNK1 and WNK4, new players in salt and water homeostasis].	Water	40-45	WNK lysine deficient protein kinase 1	Canis lupus familiaris	1-5
33440393-5	2020	Secondly, FGF10 levels were elevated in mice after TBI, whereas intraventricular injection of Ad-FGF10 decreased mNSS score and brain water content, indicating the remittance of neurological deficit and cerebral edema in TBI mice.	Water	134-139	fibroblast growth factor 10	Mus musculus	97-102
15639021-0	2005	[WNK1 and WNK4, new players in salt and water homeostasis].	Water	40-45	serine/threonine-protein kinase WNK4	Canis lupus familiaris	10-14
16075810-5	2005	Results show that Stx2 regulates the passage of water through the HRTEC within an incubation period of 1h.	Water	48-53	syntaxin 2	Homo sapiens	18-22
31749326-8	2020	In addition, PPAR-gamma was up-regulated by ACART and inhibition of PPAR-gamma abolished the regulatory effects of ACART on cell apoptosis and the expression of Bcl-2, Bax and Cyt-C under H2 O2 treatment.	Water	188-193	BCL2-associated X protein	Mus musculus	168-171
16312961-0	2005	Perception of tap water risks and quality: a structural equation model approach.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
16312961-1	2005	The present study aims to test a model of tap water risk and quality perception.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
16312961-11	2005	Finally, the use of tap water to drink at home can be moderately explained and depends mostly on the ability to use alternatives (i.e. bottled water), tap water taste, and perceived risk.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
16312961-11	2005	Finally, the use of tap water to drink at home can be moderately explained and depends mostly on the ability to use alternatives (i.e. bottled water), tap water taste, and perceived risk.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	151-154
16312961-11	2005	Finally, the use of tap water to drink at home can be moderately explained and depends mostly on the ability to use alternatives (i.e. bottled water), tap water taste, and perceived risk.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	20-23
31666300-7	2020	MPK3 and MPK6 are involved in regulating RbohD-mediated H2O2 production.	Water	56-60	mitogen-activated protein kinase 3	Arabidopsis thaliana	0-4
16312961-11	2005	Finally, the use of tap water to drink at home can be moderately explained and depends mostly on the ability to use alternatives (i.e. bottled water), tap water taste, and perceived risk.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	20-23
31666300-7	2020	MPK3 and MPK6 are involved in regulating RbohD-mediated H2O2 production.	Water	56-60	MAP kinase 6	Arabidopsis thaliana	9-13
15601617-11	2004	In the C6H6/O2/Ar system, C6H6 could be totally oxidized into CO2, CO and H2O, and no measurable phenol was found.	Water	74-77	immunoglobulin kappa variable 1D-39	Homo sapiens	7-14
31666300-8	2020	MPK3 and MPK6 are associated with protein Tyr phosphatases (PTPs), such as Tyr-specific phosphatase 1 and mitogen-activated protein kinases phosphatase 1, which negatively regulated H2O2 production.	Water	182-186	mitogen-activated protein kinase 3	Arabidopsis thaliana	0-4
31666300-8	2020	MPK3 and MPK6 are associated with protein Tyr phosphatases (PTPs), such as Tyr-specific phosphatase 1 and mitogen-activated protein kinases phosphatase 1, which negatively regulated H2O2 production.	Water	182-186	MAP kinase 6	Arabidopsis thaliana	9-13
31666300-11	2020	Collectively, our results indicate that H2Bub1 regulates NADPH oxidase RbohD-dependent H2O2 production, and the PTPs-MPK3/6-WRKY pathway plays an important role in the regulation of RbohD-dependent H2O2 signaling in defense responses to Vd-toxins in Arabidopsis.	Water	198-202	mitogen-activated protein kinase 3	Arabidopsis thaliana	117-121
15556356-2	2004	Glucose oxidase (GOx) and the water-dispersed polypyrrole complex were entrapped within polyacrylamide microgels by polymerization of acrylamide in the dispersed phase of concentrated emulsions containing GOx and PPy.	Water	30-35	hydroxyacid oxidase 1	Homo sapiens	205-208
31707353-8	2020	Impaired inflammasome activation in G6PD-kd THP-1 cells was mediated by a decrease in the production of reactive oxygen species (ROS) by NOX signaling, while treatment with hydrogen peroxide (H2O2) enhanced inflammasome activation in G6PD-kd THP-1 cells.	Water	192-196	glucose-6-phosphate dehydrogenase	Homo sapiens	36-40
31277030-3	2019	It displayed high sensitivity and selectivity to Hg2+ compared with other metal ions in H2O/DMF solvent and the detection limit was 4.2 x 10-7 M. Upon addition of Hg2+, the 1 - Hg2+ compound was formed with the formation of 2:1.	Water	88-91	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	49-52
15608599-15	2004	This increase in ethanol intake occurred whether ethanol was presented in combination with sucrose, alone (unadulterated), or as a choice with tap water.	Water	147-152	lymphocyte antigen 6 complex, locus A	Mus musculus	143-146
15010203-7	2004	Therefore, CNP may be a regulator of water homeostasis in the central nervous system.	Water	37-42	natriuretic peptide C	Homo sapiens	11-14
15267435-0	2004	Relaxation of H2O from its /04&gt;- vibrational state in collisions with H2O, Ar, H2, N2, and O2.	Water	14-17	ADP-ribosylhydrolase like 1	Homo sapiens	73-96
31277030-3	2019	It displayed high sensitivity and selectivity to Hg2+ compared with other metal ions in H2O/DMF solvent and the detection limit was 4.2 x 10-7 M. Upon addition of Hg2+, the 1 - Hg2+ compound was formed with the formation of 2:1.	Water	88-91	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	163-166
15267435-1	2004	We report rate coefficients at 293 K for the collisional relaxation of H2O molecules from the highly excited /04&gt;(+/-) vibrational states in collisions with H2O, Ar, H2, N2, and O2.	Water	71-74	ADP-ribosylhydrolase like 1	Homo sapiens	160-183
15828349-8	2004	The method has been applied to the determination of chromium in tap water and waste water with satisfactory results.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
31277030-3	2019	It displayed high sensitivity and selectivity to Hg2+ compared with other metal ions in H2O/DMF solvent and the detection limit was 4.2 x 10-7 M. Upon addition of Hg2+, the 1 - Hg2+ compound was formed with the formation of 2:1.	Water	88-91	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	163-166
31280125-0	2019	A phenanthro[9,10-d]imidazole-based AIE active fluorescence probe for sequential detection of Ag+/AgNPs and SCN- in water and saliva samples and its application in living cells.	Water	116-121	sorcin	Homo sapiens	108-111
30896265-2	2019	However, GLA presents poor solubility in water and low bioavailability through oral administration which has hindered its application in the clinic.	Water	41-46	galactosidase alpha	Homo sapiens	9-12
15633500-8	2004	RESULTS: Air and water specimens obtained from dental units supplied with tap water had microbial counts significantly (t-test, p &lt; 0.05) greater than IWR dental units.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	74-77
15633500-8	2004	RESULTS: Air and water specimens obtained from dental units supplied with tap water had microbial counts significantly (t-test, p &lt; 0.05) greater than IWR dental units.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
15544657-4	2004	(ii) The adhesive force of specimens using tap water as a medium was approximately one-half to two-third of that of specimens using resting saliva as a medium.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
15043281-4	2004	The benefits of UV photooxidation on TOC reduction for LC-MS studies were highlighted using electrospray ionization MS detection by comparing HPLC-grade bottled water, freshly produced UV185/254-treated water, and freshly produced non-UV-treated water.	Water	161-166	rhomboid 5 homolog 2	Homo sapiens	37-40
15043281-4	2004	The benefits of UV photooxidation on TOC reduction for LC-MS studies were highlighted using electrospray ionization MS detection by comparing HPLC-grade bottled water, freshly produced UV185/254-treated water, and freshly produced non-UV-treated water.	Water	203-208	rhomboid 5 homolog 2	Homo sapiens	37-40
18969359-9	2004	Real samples collected from tap water and well water were successfully analyzed using the proposed method.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
31518929-10	2019	Photocatalytic nanotechnologies represent one of the promising alternative treatments and can provide novel perspectives for a sustainable managing of natural SPA water hygiene.	Water	163-168	surfactant protein A2	Homo sapiens	159-162
15060711-8	2004	The exercise-related differences in SBP, DP and Tsk between HY and NO were increased by water ingestion (P&lt;0.05).	Water	88-93	tsukushi, small leucine rich proteoglycan	Homo sapiens	48-51
15522777-5	2004	The refined Ym1 structure at 1.31A resolution clearly displays a water cluster forming an extensive hydrogen bond network with the "active-site" residues.	Water	65-70	chitinase-like 3	Mus musculus	12-15
15522777-6	2004	This water cluster contributes notable electron density to lower resolution maps and this might have misled and given rise to a previous proposal for a monoglucosamine-binding site for Ym1.	Water	5-10	chitinase-like 3	Mus musculus	185-188
15066158-6	2004	This lentivirus vector was stereotaxically injected into the ventral tegmental area (VTA) of two groups of animals, one fed water (expressing CD81) and the other Doxycycline solution (which down-regulates CD81 expression) and locomotor activity after chronic cocaine administration (10 mg/kg daily) was monitored.	Water	124-129	Cd81 molecule	Rattus norvegicus	142-146
31585206-7	2019	Further studies showed that H2O2 regulated biological rhythm by PRX2-STAT3-REV-ERBalpha/beta pathway.	Water	28-32	nuclear receptor subfamily 1, group D, member 1	Mus musculus	75-87
31504580-0	2019	Detection of a novel mcr-5.4 gene variant in hospital tap water by shotgun metagenomic sequencing.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
15061416-9	2004	Contaminated tap water had been used to dilute alcohol for skin antisepsis and for decontamination of the caps of heparin vials.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
15061416-11	2004	CONCLUSION: This is potentially the largest single-source nosocomial bloodstream infection outbreak ever reported, and the first report of an alcohol skin antiseptic contaminated by tap water as a source for nosocomial bacteremia.	Water	186-191	nuclear RNA export factor 1	Homo sapiens	182-185
15541810-0	2004	Lung cancer mortality reduction after installation of tap-water supply system in an arseniasis-endemic area in Southwestern Taiwan.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
31768048-0	2019	Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks.	Water	35-39	src homology 2 domain-containing transforming protein C1	Mus musculus	53-59
15347663-5	2004	The expression of AQP2 and UT-A1, but not UT-A2 mRNAs, was increased to the same level as that of the wild type mice in the water deprivation state, indicating that the vasopressin regulatory mechanism was not affected by OREBPdn.	Water	124-129	solute carrier family 14 (urea transporter), member 2	Mus musculus	27-32
15527354-3	2004	120, 8107 (2004)] to the fluctuating charge (SPC-FQ) model of liquid water developed by Rick, Stuart, and Berne [J. Chem.	Water	69-74	receptor interacting serine/threonine kinase 2	Homo sapiens	88-92
14762927-3	2004	In this study, adsorption of Vn molecules on mica and oxidized titanium substrates in Milli-Q water (pH 5.6) and in simulated body fluid (SBF, pH 7.4) has been investigated using tapping mode atomic force microscopy.	Water	94-99	vitronectin	Homo sapiens	29-31
15042412-1	2004	Comparison between muscles revealed a longer spin-spin relaxation time of water in soleus than in tibialis anterior muscle (31+/-1 ms vs. 28+/-1 ms, p&lt;0.05).	Water	74-79	spindlin 1	Homo sapiens	45-49
15042412-1	2004	Comparison between muscles revealed a longer spin-spin relaxation time of water in soleus than in tibialis anterior muscle (31+/-1 ms vs. 28+/-1 ms, p&lt;0.05).	Water	74-79	spindlin 1	Homo sapiens	50-54
31768048-4	2019	Importantly, perturbations in the rhythm of H2O2 levels induced by the loss of p66Shc, which oscillates rhythmically in the liver and suprachiasmatic nucleus (SCN) of mice, disturb the rhythmic redox control of CLOCK function, reprogram hepatic transcriptome oscillations, lengthen the circadian period in mice and modulate light-induced clock resetting.	Water	44-48	src homology 2 domain-containing transforming protein C1	Mus musculus	79-85
31390577-0	2019	Sources of and solutions to mistrust of tap water originating between treatment and the tap: Lessons from Los Angeles County.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
14697697-1	2004	The interaction of bile salt/phospholipid mixed micelles with an intestinal mucin has been investigated to provide the foundation for the transport of ingested fat and poorly water-soluble drugs through the intestinal mucous layer.	Water	175-180	solute carrier family 13 member 2	Rattus norvegicus	76-81
31390577-0	2019	Sources of and solutions to mistrust of tap water originating between treatment and the tap: Lessons from Los Angeles County.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	88-91
15530321-1	2004	OBJECTIVE: To describe the characteristics of patients with tap-water scalds admitted to our hospital and review current knowledge on their prevention.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
31390577-1	2019	Tap water mistrust has adverse impacts on health and welfare.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
15530321-2	2004	PATIENTS AND METHODS: We performed a retrospective study of admissions for tap-water scalds.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
31390577-2	2019	This study identifies, defines and motivates attention to cases of mistrust of tap water which originate between the treatment plant and the tap where people ultimately consume it.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
15530321-3	2004	The medical records codified as water-tap scalds (MBDS; CIE-9-CM, 940.0-949.5, E.924.0, E.924.2) of patients admitted to our hospital for more than 24 hours from January 1 to December 31, 2003 were reviewed.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	38-41
14581464-6	2004	A functional consequence of this is that Elovl3-ablated mice exhibited a severe defect in water repulsion and increased trans-epidermal water loss.	Water	90-95	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	41-47
14581464-6	2004	A functional consequence of this is that Elovl3-ablated mice exhibited a severe defect in water repulsion and increased trans-epidermal water loss.	Water	136-141	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	41-47
31390577-2	2019	This study identifies, defines and motivates attention to cases of mistrust of tap water which originate between the treatment plant and the tap where people ultimately consume it.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	141-144
31390577-3	2019	Between treatment and the tap, water quality contamination can be introduced within two segments of the built environment with two distinct responsible parties- community water system"s distributional networks and property owner"s premise plumbing.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	26-29
15580097-1	2004	The aim of this review was to identify whether cleansing with tap water results in higher rates of wound infection or delayed healing compared with other cleansing solutions in adults or children with acute uncomplicated traumatic soft tissue wounds.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
31390577-3	2019	Between treatment and the tap, water quality contamination can be introduced within two segments of the built environment with two distinct responsible parties- community water system"s distributional networks and property owner"s premise plumbing.	Water	171-176	nuclear RNA export factor 1	Homo sapiens	26-29
31390577-5	2019	We use examples from Los Angeles County, an area with high resident tap water mistrust especially among disadvantaged communities, despite there being relatively few health-related water quality violations.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
14756568-4	2004	Our estimate reveals that 110 +/- 40 water molecules become released to the bulk from the hydration shells of BPTI and trypsinogen.	Water	37-42	spleen trypsin inhibitor I	Bos taurus	110-114
31390577-8	2019	Findings suggest that there are numerous instances where the distributional network, and secondarily premise plumbing, introduce water quality contamination which contributes to tap mistrust in urban communities by making water unclean, but not necessarily unsafe per existing regulation.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	178-181
15537939-0	2004	Remediating RDX-contaminated ground water with permanganate: laboratory investigations for the Pantex perched aquifer.	Water	36-41	radixin	Homo sapiens	12-15
31390577-8	2019	Findings suggest that there are numerous instances where the distributional network, and secondarily premise plumbing, introduce water quality contamination which contributes to tap mistrust in urban communities by making water unclean, but not necessarily unsafe per existing regulation.	Water	222-227	nuclear RNA export factor 1	Homo sapiens	178-181
15537939-1	2004	Ground water beneath the U.S. Department of Energy Pantex Plant is contaminated with the high explosive RDX (hexahydro-1,3,5-trinitro-1,3,5 triazine).	Water	7-12	radixin	Homo sapiens	104-107
31779687-7	2019	RESULTS: We found that recombinant human MG53 (rhMG53) protein protected hUC-MSCs against H2O2-induced oxidative damage and stimulated hUC-MSC proliferation and migration.	Water	90-94	tripartite motif containing 72	Homo sapiens	41-45
15522419-0	2004	Water-soluble platinum(II) complexes of diamine chelating ligands bearing amino-acid type substituents: the effect of the linked amino acid and the diamine chelate ring size on antitumor activity, and interactions with 5"-GMP and DNA.	Water	0-5	5'-nucleotidase, cytosolic II	Homo sapiens	222-225
15491674-5	2004	However, lead was absent in the local tap water and only half the concentration of selenium was present in the tap water in contrast to the ice core water.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
15076748-0	2004	Increased seizure threshold in mice lacking aquaporin-4 water channels.	Water	56-61	aquaporin 4	Mus musculus	44-55
15076748-1	2004	Mice deficient in the glial water channel aquaporin-4 (AQP4) show decreased cerebral edema and improved neurological outcome following water intoxication or ischemic challenge.	Water	28-33	aquaporin 4	Mus musculus	42-53
15076748-1	2004	Mice deficient in the glial water channel aquaporin-4 (AQP4) show decreased cerebral edema and improved neurological outcome following water intoxication or ischemic challenge.	Water	28-33	aquaporin 4	Mus musculus	55-59
15491674-5	2004	However, lead was absent in the local tap water and only half the concentration of selenium was present in the tap water in contrast to the ice core water.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
14748079-7	2004	Modification of BLG with poly-lysine yields a BLG derivative with increased affinity for the water-air interface and stronger surface tension lowering capacities than normal BLG.	Water	93-98	beta-lactoglobulin	Bos taurus	16-19
14748079-7	2004	Modification of BLG with poly-lysine yields a BLG derivative with increased affinity for the water-air interface and stronger surface tension lowering capacities than normal BLG.	Water	93-98	beta-lactoglobulin	Bos taurus	46-49
14748079-7	2004	Modification of BLG with poly-lysine yields a BLG derivative with increased affinity for the water-air interface and stronger surface tension lowering capacities than normal BLG.	Water	93-98	beta-lactoglobulin	Bos taurus	46-49
31644276-4	2019	The action of the toxin leads to disrupted permeation of water and permeation coefficients are found to be affected, from the native (2.49 +- 0.02 x 10-14 cm3/s) to toxin-treated AQP4 (7.68 +- 0.15 x 10-14 cm3/s) channels.	Water	57-62	aquaporin 4	Mus musculus	179-183
14757500-8	2004	The multiple linear regression for effectiveness of methylxanthines in reversal of P-gp mediated MDR of L1210/VCR cells (expressed as respective IC(50r) values) has been computed, with molar weight: M(w), molar volume: V(M), molar refractivity: R(M), crystal density: d and partition coefficient n-octanol/water: logP as descriptors.	Water	306-311	phosphoglycolate phosphatase	Mus musculus	83-87
31377367-1	2019	The aerosol liquid water content (ALWC) of submicron particles (PM1) was calculated in this work by three methods based on the aerosol physical and chemical properties measurement campaigns in winter in Beijing, including (a) the PM1 volume difference between the ambient and dry states by applying the particle number size distribution and particle hygroscopicity measurement; (b) the thermodynamic equilibrium model (ISORROPIA II) based on the chemical composition; and (c) the kappa-Kohler theory of chemical composition with a volume mixing scheme.	Water	19-24	transmembrane protein 11	Homo sapiens	64-67
14593089-3	2004	These studies were designed to test the hypothesis that rosiglitazone (RGZ, PPAR-gamma agonist) may activate sodium- and water-reabsorptive processes in the kidney, possibly in response to a drop in mean arterial blood pressure (MAP), as well as directly through PPAR-gamma.	Water	121-126	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	76-86
31871552-10	2019	An H2O2 donor reduced clathrin and Rab5c.	Water	3-7	RAB5C, member RAS oncogene family	Homo sapiens	35-40
15356724-3	2004	The reactions of [Pt(terpy)(H(2)O)](2+) with INO, 5"-IMP and 5"-GMP showed that these ligands are very good nucleophiles.	Water	28-34	5'-nucleotidase, cytosolic II	Homo sapiens	64-67
31585210-5	2019	In Experiment 1, chicks that received intracerebroventricular (ICV) injection of GRP reduced food intake for up to 150 min following injection and reduced water intake up to 120 min following injection.	Water	155-160	gastrin releasing peptide	Homo sapiens	81-84
14670634-1	2004	The present study investigates co-localization of AT(1A) receptor subtype and Fos protein in neuronal populations of the lamina terminalis (LT) that have been recruited during acute Na(+) and water depletion mediated by furosemide injections.	Water	192-197	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	78-81
31746021-6	2019	Moreover, we found that miR-142 reduced the Bcl-2/Bax ratio and upregulated hydrogen peroxide (H2 O2 )-induced caspase-3 expression.	Water	95-100	caspase 3	Mus musculus	111-120
14737660-2	2004	The use of Boc/Trt-protected isocysteine provided convenient access to isocysteinyl peptides that allow the chemoselective ligation of unprotected peptide fragments in water.	Water	168-173	BOC cell adhesion associated, oncogene regulated	Homo sapiens	11-14
31635452-10	2019	However, the addition of H2O2, when the background NH2Cl level was above 2 mg L-1 (as Cl2) provided limited improvement in treatment efficiency.	Water	25-29	endogenous retrovirus group W member 5	Homo sapiens	86-89
16892577-2	2004	The intake of fluorine in the form of NaF in water was 3 mg F(-)/kg b.w./24 h. The activity of sorbitol dehydrogenase (SDH) was increased in plasma and decreased in the liver of rabbits on the high-cholesterol diet and in animals simultaneously exposed to NaF in water.	Water	45-50	LOW QUALITY PROTEIN: sorbitol dehydrogenase	Oryctolagus cuniculus	95-117
16892577-2	2004	The intake of fluorine in the form of NaF in water was 3 mg F(-)/kg b.w./24 h. The activity of sorbitol dehydrogenase (SDH) was increased in plasma and decreased in the liver of rabbits on the high-cholesterol diet and in animals simultaneously exposed to NaF in water.	Water	45-50	LOW QUALITY PROTEIN: sorbitol dehydrogenase	Oryctolagus cuniculus	119-122
16892577-2	2004	The intake of fluorine in the form of NaF in water was 3 mg F(-)/kg b.w./24 h. The activity of sorbitol dehydrogenase (SDH) was increased in plasma and decreased in the liver of rabbits on the high-cholesterol diet and in animals simultaneously exposed to NaF in water.	Water	263-268	LOW QUALITY PROTEIN: sorbitol dehydrogenase	Oryctolagus cuniculus	95-117
16892577-2	2004	The intake of fluorine in the form of NaF in water was 3 mg F(-)/kg b.w./24 h. The activity of sorbitol dehydrogenase (SDH) was increased in plasma and decreased in the liver of rabbits on the high-cholesterol diet and in animals simultaneously exposed to NaF in water.	Water	263-268	LOW QUALITY PROTEIN: sorbitol dehydrogenase	Oryctolagus cuniculus	119-122
16892578-6	2004	Consumption of tap water averaged 0.73 L (max.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
30419299-5	2019	Our hypothesis is that specific lung AMPs, LL-37, alpha-defensin-1,2,3, and beta-defensin-2, are dysregulated in the lungs from organ donors who had EAU.	Water	149-152	defensin beta 4B	Homo sapiens	76-91
14643286-2	2004	The most dominant THMs are chloroform and bromodichloromethane (BDCM) in Hong Kong tap water.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
14752829-0	2004	AQP4 transfected into mouse cholangiocytes promotes water transport in biliary epithelia.	Water	52-57	aquaporin 4	Mus musculus	0-4
14752829-3	2004	In this study, we established a novel AQP4-transfected polarized mouse cholangiocyte cell line suitable for functional studies of transepithelial water transport, and, using this model, we define the importance of this AQP in water transport across biliary epithelia.	Water	146-151	aquaporin 4	Mus musculus	38-42
14752829-3	2004	In this study, we established a novel AQP4-transfected polarized mouse cholangiocyte cell line suitable for functional studies of transepithelial water transport, and, using this model, we define the importance of this AQP in water transport across biliary epithelia.	Water	226-231	aquaporin 4	Mus musculus	38-42
14752829-7	2004	In NMCs transfected with AQP4, P(f) increased to 75.7 +/- 1.4 microm/sec, that is, by 4.6-fold, indicating the contribution of AQP4 in channel-mediated water transport across MNCs monolayer.	Water	152-157	aquaporin 4	Mus musculus	25-29
14752829-7	2004	In NMCs transfected with AQP4, P(f) increased to 75.7 +/- 1.4 microm/sec, that is, by 4.6-fold, indicating the contribution of AQP4 in channel-mediated water transport across MNCs monolayer.	Water	152-157	aquaporin 4	Mus musculus	127-131
14752829-9	2004	In conclusion, we developed a novel polarized mouse cholangiocyte monolayer model, allowing direct study of AQP4-mediated water transport by biliary epithelia and generated data providing additional support for the importance of AQP4 in cholangiocyte water transport.	Water	122-127	aquaporin 4	Mus musculus	108-112
14691169-0	2004	Acanthamoeba keratitis: the role of domestic tap water contamination in the United Kingdom.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
14691169-7	2004	In six cases, identical Acanthamoeba mtDNA profiles were found for the clinical and home tap water isolates.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
15030145-8	2004	Tap water samples, when analyzed by this assay, could not be guaranteed for biological stability due to their high BDOC concentrations (0.17 to 0.23 mg/L) that corresponded to 26-36% of the initial DOC level.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
25792935-8	2004	HbD in the hypertensive group was significantly reduced in the position in water to the chest level compared to that in a standing position (p&lt;0.05).	Water	75-80	HBD	Homo sapiens	0-3
25792935-9	2004	In both groups, the ratios of HbD and HbO2 (O2/D ratio) was significantly increased in water environment compared with that out of water (p&lt;0.05).	Water	87-92	HBD	Homo sapiens	30-33
15561409-1	2004	Aquaporin-4 (AQP4) is the major water channel expressed in brain perivascular astrocyte processes.	Water	32-37	aquaporin 4	Mus musculus	13-17
15561410-11	2004	Further insight into the mechanisms by which brain AQPs are regulated will be of utmost clinical importance, since perturbed water flow via brain AQPs has been implicated in many neurological diseases and since, in brain edema, water flow via AQP4 may have a harmful effect.	Water	125-130	aquaporin 4	Homo sapiens	243-247
15561410-11	2004	Further insight into the mechanisms by which brain AQPs are regulated will be of utmost clinical importance, since perturbed water flow via brain AQPs has been implicated in many neurological diseases and since, in brain edema, water flow via AQP4 may have a harmful effect.	Water	228-233	aquaporin 4	Homo sapiens	243-247
15561413-0	2004	New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice.	Water	18-23	aquaporin 4	Mus musculus	101-112
15561413-1	2004	Aquaporin-4 (AQP4) is the major water channel in the CNS.	Water	32-37	aquaporin 4	Mus musculus	0-11
15561413-1	2004	Aquaporin-4 (AQP4) is the major water channel in the CNS.	Water	32-37	aquaporin 4	Mus musculus	13-17
15561413-4	2004	Primary cultures of astrocytes from AQP4-null mice have greatly reduced osmotic water permeability compared with wild-type astrocytes, indicating that AQP4 is the principal water channel in these cells.	Water	80-85	aquaporin 4	Mus musculus	36-40
15561413-4	2004	Primary cultures of astrocytes from AQP4-null mice have greatly reduced osmotic water permeability compared with wild-type astrocytes, indicating that AQP4 is the principal water channel in these cells.	Water	173-178	aquaporin 4	Mus musculus	36-40
15561413-4	2004	Primary cultures of astrocytes from AQP4-null mice have greatly reduced osmotic water permeability compared with wild-type astrocytes, indicating that AQP4 is the principal water channel in these cells.	Water	173-178	aquaporin 4	Mus musculus	151-155
15561413-6	2004	In contrast, brain swelling and clinical outcome are worse in AQP4-null mice in models of vasogenic (fluid leak) edema caused by freeze-injury and brain tumor, probably due to impaired AQP4-dependent brain water clearance.	Water	206-211	aquaporin 4	Mus musculus	62-66
15561413-6	2004	In contrast, brain swelling and clinical outcome are worse in AQP4-null mice in models of vasogenic (fluid leak) edema caused by freeze-injury and brain tumor, probably due to impaired AQP4-dependent brain water clearance.	Water	206-211	aquaporin 4	Mus musculus	185-189
15561414-2	2004	The molecular membrane water channel aquaporin-4 (AQP4) has been shown to be present at the blood-brain barrier (BBB) where it plays pivotal role in the transport of water between the tissue water compartments of the brain.	Water	23-28	aquaporin 4	Mus musculus	50-54
15561414-2	2004	The molecular membrane water channel aquaporin-4 (AQP4) has been shown to be present at the blood-brain barrier (BBB) where it plays pivotal role in the transport of water between the tissue water compartments of the brain.	Water	166-171	aquaporin 4	Mus musculus	50-54
15561414-2	2004	The molecular membrane water channel aquaporin-4 (AQP4) has been shown to be present at the blood-brain barrier (BBB) where it plays pivotal role in the transport of water between the tissue water compartments of the brain.	Water	166-171	aquaporin 4	Mus musculus	50-54
15561414-14	2004	These results demonstrate that dystrophin is necessary for polarized distribution of AQP4 protein in brain where facilitated movements of water occur across the BBB and cerebrospinal fluid-brain interface.	Water	138-143	aquaporin 4	Mus musculus	85-89
15561415-0	2004	Anchoring of aquaporin-4 in brain: molecular mechanisms and implications for the physiology and pathophysiology of water transport.	Water	115-120	aquaporin 4	Mus musculus	13-24
15561416-5	2004	AQP4-deficient mice show remarkably altered brain water balance after various insults, including brain tumour implantation.	Water	50-55	aquaporin 4	Mus musculus	0-4
14670455-2	2004	The structure, stability and vibrational spectrum of the binary complex between HONO2 and H2O have been investigated using ab initio calculations at SCF and MP2 levels with different basis sets and B3LYP/6-31G(d,p) calculations.	Water	90-93	KIT ligand	Homo sapiens	149-152
14754084-2	2003	The spin asymmetry in the SP of He(*) scattered from a clean Fe/Cu(100) surface changed its polarity with H2O adsorption.	Water	106-109	spindlin 1	Homo sapiens	4-8
14640600-7	2003	Analysis of cell wall polysaccharides size indicated that LeExp1 overexpression enhanced depolymerization of water soluble pectins as well as tightly bound matrix glycans.	Water	109-114	expansin	Solanum lycopersicum	58-64
14523607-8	2003	Removal of chloride by washing the sediment with Milli-Q water significantly reduced dissolution of added HgS during extraction by concentrated HNO3.	Water	57-62	hepatocyte growth factor-regulated tyrosine kinase substrate	Homo sapiens	106-109
14645081-1	2003	In mixed alcohol-water solvents, bovine beta-lactoglobulin undergoes a cooperative transition from beta-sheet to a high alpha-helix content conformer.	Water	17-22	beta-lactoglobulin	Bos taurus	40-58
14644662-6	2003	Periodic urine samples were collected from early to late pregnancy among 29 pregnant women living in Antofagasta, Chile, who drank tap water containing 40 micro g/L In-As.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	131-134
14983080-4	2003	The chloride ion pore for Cl2 (one of the two chloride ions revealed in the X-ray structure of tACE) that connects the external solution with the inner part of the protein was identified on the basis of an extended network of water molecules.	Water	226-231	endogenous retrovirus group W member 5	Homo sapiens	26-29
14983080-4	2003	The chloride ion pore for Cl2 (one of the two chloride ions revealed in the X-ray structure of tACE) that connects the external solution with the inner part of the protein was identified on the basis of an extended network of water molecules.	Water	226-231	ADAM metallopeptidase domain 17	Homo sapiens	95-99
12949080-6	2003	The bacterial CutA1 is able to bind copper(II) in vitro through His2Cys coordination in a type II water-accessible site, whereas the rat protein precipitates in the presence of copper(II).	Water	98-103	cutA divalent cation tolerance homolog	Rattus norvegicus	14-19
14507725-1	2003	X-ray reflectivity of bovine and sheep surfactant-associated protein B (SP-B) monolayers is used in conjunction with pressure-area isotherms and protein models to suggest that the protein undergoes changes in its tertiary structure at the air/water interface under the influence of surface pressure, indicating the likely importance of such changes to the phenomena of protein squeeze out as well as lipid exchange between the air-water interface and subphase structures.	Water	243-248	pulmonary surfactant-associated protein B	Ovis aries	72-76
12951051-0	2003	Reduction of chemokine IL-8 and RANTES expression in human bronchial epithelial cells by a sea-water derived saline through inhibited nuclear factor-kappaB activation.	Water	95-100	C-C motif chemokine ligand 5	Homo sapiens	32-38
12941327-2	2003	The structure-activity relationships of the C-4 aniline substituents were explored, and water-solubilizing groups were added at the C-7 position to improve physical properties.	Water	88-93	complement C7	Homo sapiens	132-135
12940901-2	2003	Many water-soluble mediators with pro- and anti-inflammatory action such as TNF, IL-6, IL-8, and IL-10 play a strategic role in septic syndrome.	Water	5-10	interleukin 10	Homo sapiens	97-102
12944311-6	2003	In glycerol/water these bands reflect the glass transition at approximately 160 K. The fluorescence of N-acetyl-L-tryptophanamide and tryptophan of melittin, Ca-free parvalbumin, and staphylococcal nuclease in dry trehalose/sucrose films remains broad and red-shifted over a temperature excursion of 20-300 K. In contrast, the fluorescence of these compounds in glycerol/water solvent shift to the blue as temperature decreases.	Water	12-17	parvalbumin	Homo sapiens	166-177
15717533-1	2004	Patients with disorders of motor-evacuatory gastric function and those of the gallbladder received sanatorium spa treatment with Nizhneivkinskaya 2K mineral water.	Water	157-162	surfactant protein A2	Homo sapiens	110-113
15514152-3	2004	This energy equals the latent heat of melting of ice with hexagonal symmetry (ice Ih) and is consistent with the distribution of hydrogen bond strengths obtained for the "overstructured" ST2 model of water.	Water	200-205	ST2	Homo sapiens	187-190
18969645-9	2004	Low levels of dichloromethane and chloroform ranging from 0.04 to 1.13mugg(-1) were found in samples obtained from small gardens irrigated with tap water.	Water	148-153	nuclear RNA export factor 1	Homo sapiens	144-147
15386627-0	2004	Quantification of water diffusion and relaxation times of human U87 tumors in a mouse model.	Water	18-23	small nucleolar RNA, C/D box 87	Homo sapiens	64-67
15386627-5	2004	In this study, we measured the diffusion, T1 and T2 characteristics of water in the human U87 tumor at 8.5 T in an orthotopic murine model in vivo and analyzed their detailed changes in the transition from the tumor core through the tumor periphery, and out to surrounding tissue using custom developed radial profile analysis software.	Water	71-76	small nucleolar RNA, C/D box 87	Homo sapiens	90-93
15379542-1	2004	Using magnetic relaxation dispersion (MRD), we have previously shown that the four internal water molecules in bovine pancreatic trypsin inhibitor (BPTI) exchange with bulk water on time scales between 10(-8) and 10(-4) s at room temperature.	Water	92-97	spleen trypsin inhibitor I	Bos taurus	111-146
15379542-1	2004	Using magnetic relaxation dispersion (MRD), we have previously shown that the four internal water molecules in bovine pancreatic trypsin inhibitor (BPTI) exchange with bulk water on time scales between 10(-8) and 10(-4) s at room temperature.	Water	92-97	spleen trypsin inhibitor I	Bos taurus	148-152
15379542-1	2004	Using magnetic relaxation dispersion (MRD), we have previously shown that the four internal water molecules in bovine pancreatic trypsin inhibitor (BPTI) exchange with bulk water on time scales between 10(-8) and 10(-4) s at room temperature.	Water	173-178	spleen trypsin inhibitor I	Bos taurus	111-146
15379542-1	2004	Using magnetic relaxation dispersion (MRD), we have previously shown that the four internal water molecules in bovine pancreatic trypsin inhibitor (BPTI) exchange with bulk water on time scales between 10(-8) and 10(-4) s at room temperature.	Water	173-178	spleen trypsin inhibitor I	Bos taurus	148-152
15379542-6	2004	The relation of water exchange to other dynamic processes in BPTI is discussed.	Water	16-21	spleen trypsin inhibitor I	Bos taurus	61-65
15231818-9	2004	Following AC(VI) gene transfer, when cardiac myocytes were stimulated with isoproterenol or NKH477, a water-soluble forskolin analog that directly stimulates AC, expression of ATF3 protein was increased even more, which correlated with reduced expression of PLB.	Water	102-107	activating transcription factor 3	Rattus norvegicus	176-180
15371236-0	2004	Ischemic heart disease mortality reduction in an arseniasis-endemic area in southwestern Taiwan after a switch in the tap-water supply system.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
15126246-2	2004	Water deprivation increased the B(max) of glomerular binding sites for ANP(1-28) and C-type natriuretic peptide (CNP)(1-22) without modifying their affinity, an effect that was prevented in the presence of C-atrial natriuretic factor (C-ANF), suggesting that natriuretic peptide receptor-C (NPR-C) binding sites might be enhanced.	Water	0-5	natriuretic peptide C	Rattus norvegicus	85-111
15126246-2	2004	Water deprivation increased the B(max) of glomerular binding sites for ANP(1-28) and C-type natriuretic peptide (CNP)(1-22) without modifying their affinity, an effect that was prevented in the presence of C-atrial natriuretic factor (C-ANF), suggesting that natriuretic peptide receptor-C (NPR-C) binding sites might be enhanced.	Water	0-5	natriuretic peptide C	Rattus norvegicus	113-116
15126246-5	2004	Our observations suggest that this effect must be attributed to the 67-kDa NPR-C-like protein, because the 67- and 77-kDa NPR-C-like proteins show high and low affinities for CNP(1-22), respectively, and the enhanced inhibitory effect of CNP on cAMP generation in water-deprived rats was detected at subnanomolar concentrations.	Water	264-269	natriuretic peptide C	Rattus norvegicus	175-178
15191914-1	2004	The physiological role of the duodenal peptide secretin is as a potent stimulant of electrolyte and water movement in pancreatic and biliary epithelium, via activation of G protein-coupled secretin receptors (hSCTR).	Water	100-105	secretin	Homo sapiens	47-55
15191914-1	2004	The physiological role of the duodenal peptide secretin is as a potent stimulant of electrolyte and water movement in pancreatic and biliary epithelium, via activation of G protein-coupled secretin receptors (hSCTR).	Water	100-105	secretin	Homo sapiens	189-197
15316185-0	2004	A probabilistic estimation of fluoride intake by infants up to the age of 4 months from infant formula reconstituted with tap water in the fluoridated regions of Ireland.	Water	126-131	nuclear RNA export factor 1	Homo sapiens	122-125
15316185-1	2004	Two probabilistic models were developed to estimate the acute and chronic exposure to fluoride of exclusively formula-fed infants aged 0-4 months as a result of the consumption of infant formula reconstituted with fluoridated tap water in Ireland.	Water	230-235	nuclear RNA export factor 1	Homo sapiens	226-229
12944311-7	2003	The fluorescence of the buried tryptophan in Ca-bound parvalbumin in either sugar film or glycerol/water remains blue-shifted and has vibronic resolution over the entire temperature range.	Water	99-104	parvalbumin	Homo sapiens	54-65
12867198-0	2003	The mutagenic potentials of tap water samples in Shanghai.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
12867198-5	2003	Two tap water samples from city north, which were directly from Yangtze River, were also not mutagenic.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
12867198-7	2003	The boiled water displayed an even stronger mutagenic potential compared to its original tap water.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	89-92
12867198-7	2003	The boiled water displayed an even stronger mutagenic potential compared to its original tap water.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
31237362-4	2019	Among biological actions, the activation of central SST signaling induced a robust stimulation of food and water intake, which is mediated by the sst2 as assessed using selective sst agonists.	Water	107-112	somatostatin	Homo sapiens	52-55
12867198-10	2003	Qualitatively similar spectra were observed except for the peaks of three chlorinated aromatic hydrocarbon compounds, which existed only in the tap water.	Water	148-153	nuclear RNA export factor 1	Homo sapiens	144-147
12928419-9	2003	In contrast to our postulate, neutralization of RANTES by specific Ab in vivo on days 9 and 13 exacerbated EAU.	Water	107-110	C-C motif chemokine ligand 5	Homo sapiens	48-54
15365006-3	2004	An AFLP genotype, termed AF1, was predominant in isolates from both patients (40.5%) and water (49.0%).	Water	89-94	interferon gamma receptor 2	Homo sapiens	25-28
15388290-0	2004	Cholecystokinin tetrapeptide improves water maze performance of neonatally 6-hydroxydopamine-lesioned young rats.	Water	38-43	cholecystokinin	Rattus norvegicus	0-15
31237362-4	2019	Among biological actions, the activation of central SST signaling induced a robust stimulation of food and water intake, which is mediated by the sst2 as assessed using selective sst agonists.	Water	107-112	somatostatin	Homo sapiens	146-149
31759341-0	2019	Helicobacter Pylori Detected in Tap Water of Peruvian Patients with Gastric Cancer.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
12973368-8	2003	Trends in these estimates for Cape Cod suggest increasing impact to drinking water quality for land use over the study period.	Water	77-82	structural maintenance of chromosomes 2	Homo sapiens	30-34
31759341-1	2019	OBJECTIVE: To evaluate the correlation between the presence of H. pylori in paired samples of tap water and gastric cancer (GC) lesion in Lima city (Peru).	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
15348397-2	2003	Subsequently, grafting copolymerization with acrylic acid (AAc) makes the plasma-treated fabric durably hydrophilic and excellent in water absorbency.	Water	133-138	glycine-N-acyltransferase	Homo sapiens	59-62
15298924-0	2004	Structure of human annexin a6 at the air-water interface and in a membrane-bound state.	Water	41-46	annexin A6	Homo sapiens	19-29
15298924-2	2004	Brewster angle microscopy shows that AnxA6, AnxA6a, and AnxA6b in the absence of lipids accumulate at the air-water interface and form a stable, homogeneous layer at pH below 6.0.	Water	110-115	annexin A6	Homo sapiens	37-42
31759341-7	2019	H. pylori was detected in 69.5% of gastric tissues and in 12.2% of analyzed tap-water.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
31759341-9	2019	Conclusion & Impact: H. pylori was found in tap-water samples, however, detection rates were lower than in gastric cancer samples.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
31422171-5	2019	In this study, we performed the one-step synthesis of water-dispersible ultra-small iron oxide nanoparticles (USPIONs) and combine them with an imidazopyridine based TSPO ligand and a fluorescent dye.	Water	54-59	translocator protein	Homo sapiens	166-170
15495789-4	2004	Mice were fed with rutin or CGA in drinking water during antigen sensitization, followed by antigenic challenge i.p.	Water	44-49	chromogranin A	Mus musculus	28-31
14516006-3	2003	The MIR was transformed by normalisation, correction of baseline using the second derivative, and suppression of the signals of water and carbon dioxide.	Water	128-133	membrane associated ring-CH-type finger 8	Homo sapiens	4-7
31158313-9	2019	The probability of drinking tap water perceived as safe (77%) or as not safe (11%) suggested households in BOFN contradicted their perception and consumed water perceived as unsafe.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	28-31
15058835-2	2003	The aim of this report is to compare a bottled spring water with a very low mineral content with tap water in the reconstitution and/or dilution of 6 different infant starting formulas and cow"s milk.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
15273299-9	2004	For PQQH--&gt;PQQH2, migration of H5 to the C4 oxygen may be assisted by a weak base like water (either by crystal water Wat97 or bulk solvent, hydrogen-bonded to Glu 171-CO2- in MDH and by Wat89 in sGDH).	Water	90-95	malate dehydrogenase 2	Homo sapiens	179-182
31556998-5	2019	Like other AnO2+, americyl(V) and curyl(V) adsorb up to four H2O molecules to form tetrahydrates AnO2(H2O)4+ with the actinide hexacoordinated by oxygen atoms.	Water	61-64	anoctamin 2	Homo sapiens	97-101
15101820-0	2004	The water- and salt-stress-regulated Asr1 (abscisic acid stress ripening) gene encodes a zinc-dependent DNA-binding protein.	Water	4-9	abscisic stress-ripening protein 1	Solanum lycopersicum	37-41
15101820-1	2004	Tomato (Lycopersicon esculantum) ASR1 (abscisic acid stress ripening protein), a small plant-specific protein whose cellular mode of action defies deduction based on its sequence or homology analyses, is one of numerous plant gene products with unknown biological roles that become over-expressed under water- and salt-stress conditions.	Water	303-308	abscisic stress-ripening protein 1	Solanum lycopersicum	33-37
12892940-1	2003	A butenolide-containing sugar available from the aldol condensation of methyl 4,6-O-benzylidene-alpha-D-glucopyranosid-2-ulose with diethyl malonate is autoxidized at the C-3 position into the corresponding alpha,beta-unsaturated gamma-lactone sugar by air, which subsequently undergoes 1,4-conjugate (Michael) addition of hydroxide ion (or water) leading to a C-branched-chain glucopyranosidulose.	Water	341-346	complement C3	Homo sapiens	171-174
31532667-0	2019	One-Step Facile Synthesis of Nitrogen-Doped Carbon Dots: A Ratiometric Fluorescent Probe for Evaluation of Acetylcholinesterase Activity and Detection of Organophosphorus Pesticides in Tap Water and Food.	Water	189-194	nuclear RNA export factor 1	Homo sapiens	185-188
15231996-7	2004	Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis.	Water	10-15	apelin	Rattus norvegicus	132-138
15231996-7	2004	Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis.	Water	10-15	apelin	Rattus norvegicus	232-238
31532667-2	2019	In this study, a highly selective and sensitive ratiometric fluorescent probe was innovatively fabricated for the evaluation of AChE activity and the determination of OPs in tap water and food on the basis of the inner filter effect (IFE) between nitrogen-doped carbon dots (N-CDs) and 2,3-diaminophenazine (DAP).	Water	178-183	nuclear RNA export factor 1	Homo sapiens	174-177
31365250-9	2019	The time to form the QM-EFP2 Fock operator per SCF iteration for water clusters scales linearly with the number EFP basis functions.	Water	65-70	KIT ligand	Homo sapiens	47-50
15222753-6	2004	Detailed analysis of the water structure around Gln262 and the active site Cys215 reveals that the probability of finding a water molecule correctly positioned for catalysis is much larger in PTP1B than in PTP1B(R47V,D48N,M258C,G259Q) and PTPalpha, in accordance with experiments.	Water	25-30	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	192-197
15222753-6	2004	Detailed analysis of the water structure around Gln262 and the active site Cys215 reveals that the probability of finding a water molecule correctly positioned for catalysis is much larger in PTP1B than in PTP1B(R47V,D48N,M258C,G259Q) and PTPalpha, in accordance with experiments.	Water	25-30	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	206-211
15222753-6	2004	Detailed analysis of the water structure around Gln262 and the active site Cys215 reveals that the probability of finding a water molecule correctly positioned for catalysis is much larger in PTP1B than in PTP1B(R47V,D48N,M258C,G259Q) and PTPalpha, in accordance with experiments.	Water	124-129	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	192-197
15222753-6	2004	Detailed analysis of the water structure around Gln262 and the active site Cys215 reveals that the probability of finding a water molecule correctly positioned for catalysis is much larger in PTP1B than in PTP1B(R47V,D48N,M258C,G259Q) and PTPalpha, in accordance with experiments.	Water	124-129	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	206-211
31479580-4	2019	Herein, we report longitudinal relaxation times (T1 ) and lifetimes of pH2 ( tau P O C   ) in methanol and water, with or without O2 , NaCl, rhodium-catalyst or human blood.	Water	107-112	polyhomeotic homolog 2	Homo sapiens	71-74
31536092-7	2019	Configuration interaction applications to single bond dissociations of water and glycine, and multiple bond dissociations of ethylene and oxygen produce dissociation energy curves in close agreement with CI calculations based on canonical SCF orbitals for the entire range of internuclear distances.	Water	71-76	KIT ligand	Homo sapiens	239-242
31575764-11	2019	This study is the first to demonstrate the deleterious effects that neonicotinoids can have on Duox-mediated generation of H2O2 and highlights a novel coordination between two important innate immune pathways present in insects.IMPORTANCE Sublethal exposure to certain pesticides (e.g., neonicotinoid insecticides) is suspected to contribute to honey bee (Apis mellifera) population decline in North America.	Water	123-127	dual oxidase	Apis mellifera	95-99
31446306-2	2019	Generation of the "C3b-like" C3(H2O) has been described as essential for AP activation, since it conveniently explains how the initial fluid-phase AP convertase of the amplification loop is generated.	Water	32-35	complement C3	Homo sapiens	19-22
31576091-12	2019	After treatment with Sirt1-siRNA or Sirt1 inhibitor (EX527), the hyperacetylated HMGB1 in hepatocytes increased, and Sirt1 activity inhibited by H2O2 could be reversed by Parp1 inhibitor (DIQ).	Water	145-149	poly (ADP-ribose) polymerase family, member 1	Mus musculus	171-176
31465193-2	2019	Herein, an innovative bifunctional nanocomposite HFO@TPR was developed for synchronous nitrate/phosphate elimination from water.	Water	122-127	translocated promoter region, nuclear basket protein	Homo sapiens	53-56
31616834-2	2019	Herein, we report the first examples of mononuclear cyclometallated iridium(III) complexes incorporating phosphonate ligands, namely, [Ir(ppy)2(HL1)] 0.5H2O (1), [Ir(ppy)2(HL2)] 0.5H2O (2), [Ir(dfppy)2(HL1)] (3), and [Ir(dfppy)2(HL2)] 3.5H2O (4) (ppy = 2-phenylpyridine, dfppy = 2-(2,4-difluorophenyl)pyridine, H2L1 = 2-pyridylphosphonic acid, H2L2 = 2-quinolinephosphonic acid).	Water	152-156	asialoglycoprotein receptor 2	Homo sapiens	172-175
31616834-2	2019	Herein, we report the first examples of mononuclear cyclometallated iridium(III) complexes incorporating phosphonate ligands, namely, [Ir(ppy)2(HL1)] 0.5H2O (1), [Ir(ppy)2(HL2)] 0.5H2O (2), [Ir(dfppy)2(HL1)] (3), and [Ir(dfppy)2(HL2)] 3.5H2O (4) (ppy = 2-phenylpyridine, dfppy = 2-(2,4-difluorophenyl)pyridine, H2L1 = 2-pyridylphosphonic acid, H2L2 = 2-quinolinephosphonic acid).	Water	152-156	asialoglycoprotein receptor 2	Homo sapiens	229-232
31527917-3	2019	We classified ARGs in manure-treated drainage effluent water by its source of origin.	Water	55-60	serpin family A member 2 (gene/pseudogene)	Homo sapiens	14-18
31527917-4	2019	Overall, we found that 61% and 7% of the total abundance of ARGs found in drainage water samples could be attributed to manure enrichment and manure addition, respectively.	Water	83-88	serpin family A member 2 (gene/pseudogene)	Homo sapiens	60-64
31527917-5	2019	Among these ARGs, we identified 75 genes unique to manure that persisted in both soil and drainage water throughout a drainage season typical of the Upper Midwestern United States.	Water	99-104	serpin family A member 2 (gene/pseudogene)	Homo sapiens	12-16
31418568-3	2019	The benzene-Cl2/Br2 binding energies (13.07 +- 0.42/16.62 +- 0.02 kJ/mol) attributed to both halogen bonding and dispersion are smaller than but comparable to the typical hydrogen bonding in the water dimer binding energy (20.88 +- 0.27 kJ/mol).	Water	195-200	endogenous retrovirus group W member 5	Homo sapiens	12-15
31433944-3	2019	It is shown that the GroEL nanobarrel is highly surface-active and allows the formation of Pickering emulsion by physical adsorption at the oil/water interface.	Water	144-149	heat shock protein family D (Hsp60) member 1	Homo sapiens	21-26
31501424-2	2019	Here we report the generation of block copolymer Moebius strips via a fast self-assembly of chiral block copolymer polystyrene-block-poly(D-lactide acid) (PS-b-PDLA) in tetrahydrofuran/water mixed solvents.	Water	185-190	PDON2	Homo sapiens	160-164
31517119-1	2019	Fluoride intake from tap water supplied by fluoride-containing groundwater has been the primary cause of fluorosis among the residents of Buak Khang Subdistrict, Chiang Mai Province, Thailand.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
31517119-9	2019	The fluoride intake from using tap water for drinking and cooking was estimated to be 0.18 +- 0.10 mg/kg-body weight/day and 5.55 +- 3.52 mg/capita/day, respectively, whereas using bottled water for drinking and cooking reduced the fluoride intake to 0.002 +- 0.002 mg/kg-body weight/day and 0.07 +- 0.05 mg/capita/day, respectively.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
31136861-4	2019	Moreover, DSH had good water solubility, and was successfully applied to bioimage intracellular Zn2+ ions and Na2EDTA in two different living cells with exciting cellular permeability and low cytotoxicity, which indicated that DSH had great potential in the application of biological imaging.	Water	23-28	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	10-13
31486902-12	2019	In addition, good recoveries of 91.3-119.0% were found for tap water, river water and artificial urine spiked with OFL with relative standard deviation (RSD) of &lt;=11.6%.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
31392770-6	2019	The CNF-based 3D aerogels prove effective for absorption of ILs from aqueous biphasic systems and recovery with quite low water contents just through a single process of filtration.	Water	122-127	NPHS1 adhesion molecule, nephrin	Homo sapiens	4-7
31238205-9	2019	Women assigned to the intervention group received warm compresses made from clean washcloths or perineal pads immersed in warm tap water.	Water	131-136	nuclear RNA export factor 1	Homo sapiens	127-130
31087583-4	2019	Here, we determined that St2-/- substantially reduced scratching behaviors in 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD) as well as acetone and diethylether followed by water-induced dry skin in mice.	Water	200-205	interleukin 1 receptor-like 1	Mus musculus	25-28
31255881-4	2019	In this study, the lentivirus with NLRP1-siRNA was injected into the hippocampus of male mice which were then treated with dexamethasone (DEX, 5 mg/kg) for 28 d. The data indicated that NLRP1-siRNA treatment down-regulated the NLRP1 expression and significantly improved the exploratory behavior and spatial memory deficits in open field tests and Morris water maze which were deteriorated by chronic DEX treatment in mice.	Water	355-360	NLR family, pyrin domain containing 1A	Mus musculus	35-40
31255881-4	2019	In this study, the lentivirus with NLRP1-siRNA was injected into the hippocampus of male mice which were then treated with dexamethasone (DEX, 5 mg/kg) for 28 d. The data indicated that NLRP1-siRNA treatment down-regulated the NLRP1 expression and significantly improved the exploratory behavior and spatial memory deficits in open field tests and Morris water maze which were deteriorated by chronic DEX treatment in mice.	Water	355-360	NLR family, pyrin domain containing 1A	Mus musculus	186-191
31255881-4	2019	In this study, the lentivirus with NLRP1-siRNA was injected into the hippocampus of male mice which were then treated with dexamethasone (DEX, 5 mg/kg) for 28 d. The data indicated that NLRP1-siRNA treatment down-regulated the NLRP1 expression and significantly improved the exploratory behavior and spatial memory deficits in open field tests and Morris water maze which were deteriorated by chronic DEX treatment in mice.	Water	355-360	NLR family, pyrin domain containing 1A	Mus musculus	186-191
30901080-7	2019	AQP4 characterizes a brain-wide water transport system in cerebral cortex with regional differences in immunoreactivity at midgestation.	Water	32-37	aquaporin 4	Homo sapiens	0-4
31750822-15	2019	Conclusion TSA attenuates H2O2-induced endothelial cell senescence by activating SIRT1/eNOS signaling pathway.	Water	26-30	sirtuin 1	Homo sapiens	81-86
15323996-3	2004	Based on our results, we propose that STM images and photoemission experiments may detect specific changes induced by water on both the structural and electronic properties of SiC(001) surfaces.	Water	118-123	sulfotransferase family 1A member 3	Homo sapiens	38-41
31799961-7	2019	The implications of the EPS characteristics were further discussed with respect to water treatment.	Water	83-88	14-3-3epsilon	Drosophila melanogaster	24-27
15230888-1	2004	BACKGROUND: Direct electrical current (d.c.) administration based on tap water iontophoresis has been used as a therapeutic option for palmoplantar hyperhidrosis.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
31464621-9	2019	Effective compliance rate with safe drinking water practices, either by storing clean drinking water or boiling tap water, after a water outage was 72% among those who remembered receiving a notification.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	112-115
15248985-9	2004	The method was used to measure bromide in river water and tap water.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
31464621-11	2019	The main reason for respondents" non-compliance with safe water practices was that they perceived the water to be safe to drink after letting it flush through the tap until it became clear.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	163-166
31464621-11	2019	The main reason for respondents" non-compliance with safe water practices was that they perceived the water to be safe to drink after letting it flush through the tap until it became clear.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	163-166
31555266-1	2019	Trichloroethylene (TCE) is an industrial solvent and drinking water pollutant associated with CD4+ T cell-mediated autoimmunity.	Water	62-67	CD4 antigen	Mus musculus	94-97
15212549-2	2004	Two different protein cavities, in bovine pancreatic trypsin inhibitor (BPTI) and in the I76A mutant of barnase, represent very different environments for the water molecule: one which is polar, forming four water-protein hydrogen bonds, and one which is more hydrophobic, forming only one water-protein hydrogen bond.	Water	159-164	spleen trypsin inhibitor I	Bos taurus	72-76
12715185-6	2003	Accumulation of AQP4 IR may reflect its participation in the development of brain edema in human brains by playing a role in the transport of water not only through blood vessel walls but also through pial and ependymal surface of the brain.	Water	142-147	aquaporin 4	Homo sapiens	16-20
15198580-1	2004	Three-dimensional particle crystals made of dicarboxylic thiolate (MSA)-stabilized gold nanoparticles were formed at an air/water interface.	Water	124-129	thyroid peroxidase	Homo sapiens	67-70
31460521-3	2019	We show that the iEL-SCF is able to reduce the number of SCF cycles by 50-80% of the original conjugate gradient self-consistent field solver as tested across diverse systems including water, ferric hydroxide, nitramine RDX, and hexanitrostilbene.	Water	185-190	KIT ligand	Homo sapiens	21-24
31444371-7	2019	At baseline, hepsin-deficient mice accumulate uromodulin, along with hyperactivated NKCC2, resulting in a positive sodium balance and a better adaptation to water deprivation.	Water	157-162	hepsin	Mus musculus	13-19
12689853-5	2003	In the latter group, tap water (2,000 ml) was administered intragastrically to the ewe followed by DDAVP (20 microg bolus, 4 microg/h) and a maintenance intravenous infusion of 5% dextrose water for 4 h to achieve maternal hyponatremia of 10-12 meq/l.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
31324450-0	2019	Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters.	Water	100-105	serine carboxypeptidase 1	Homo sapiens	44-48
12859978-5	2003	Thereby, the nucleotide extended, anti conformation in pure water typical for nucleotides in DNA was forced by the cationic bilayer to become syn.	Water	60-65	synemin	Homo sapiens	142-145
31324450-5	2019	We also identified two water pockets beneath the nucleic acid-binding channel that appeared to stabilize the mature RISC.	Water	23-28	serine carboxypeptidase 1	Homo sapiens	116-120
14567450-6	2003	Our results demonstrate that ascorbic acid can induce a pH dependent hydroxyl radical generating reaction in copper contaminated household tap water that is buffered with bicarbonate.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
31324450-6	2019	Indeed, mutating the water-pocket residues of Argonaute2 and Argonaute4 compromised RISC assembly.	Water	21-26	argonaute RISC component 4	Homo sapiens	61-71
31324450-6	2019	Indeed, mutating the water-pocket residues of Argonaute2 and Argonaute4 compromised RISC assembly.	Water	21-26	serine carboxypeptidase 1	Homo sapiens	84-88
31324450-8	2019	These results suggest that after guide RNA-driven conformational changes, water-mediated hydrogen-bonding networks tie together the converged domains to complete the functional RISC structure.	Water	74-79	serine carboxypeptidase 1	Homo sapiens	177-181
12875842-8	2003	We demonstrate that over-expression of MDL1 in Deltaatm1 cells results in a reduction of mitochondrial iron content, and decreased sensitivity to H(2)O(2) and transition metal toxicity.	Water	146-151	ATP-binding cassette permease MDL1	Saccharomyces cerevisiae S288C	39-43
30785272-1	2019	The aim was to characterize a phenolic-rich water extract from the pericarp of an improved genotype of Apache red maize (RPE) and evaluate its ability to activate the type 2 diabetes markers free fatty acid receptor 1 (GPR40) and glucokinase (GK) in vitro.	Water	44-49	ribulose-5-phosphate-3-epimerase	Homo sapiens	121-124
12918118-1	2003	AIM: To determine the changes of pS2 and ITF of TFF expression in gastric mucosa and the effect on ulcer healing of pS2, ITF to Water-immersion and restraint stress (WRS) in rats.	Water	128-133	trefoil factor 3	Rattus norvegicus	121-124
30785272-1	2019	The aim was to characterize a phenolic-rich water extract from the pericarp of an improved genotype of Apache red maize (RPE) and evaluate its ability to activate the type 2 diabetes markers free fatty acid receptor 1 (GPR40) and glucokinase (GK) in vitro.	Water	44-49	free fatty acid receptor 1	Rattus norvegicus	219-224
12945698-6	2003	The balance in reactivity is attributed to the additional stability obtained in the six membered cyclic compounds by a syn orientation of the two lone pairs of the cyclic nitrogen to the water attack.	Water	187-192	synemin	Homo sapiens	119-122
12945698-9	2003	The syn orientation of two electron pairs on nitrogen stabilizes the transition state of water approach to the phosphoramides by ca.	Water	89-94	synemin	Homo sapiens	4-7
31128332-1	2019	Taste and odour (T&amp;O) compounds (most commonly 2-MIB and Geosmin) in drinking water are becoming an increasingly global problem for water management.	Water	82-87	MIB E3 ubiquitin protein ligase 1	Homo sapiens	53-56
12814971-8	2003	The component(s) responsible for nNOS inactivation is not volatile, is not retained by a 3,000 molecular weight cut-off membrane, binds to activated charcoal, and is highly water-soluble under both acidic and basic conditions.	Water	173-178	nitric oxide synthase 1	Rattus norvegicus	33-37
31128332-1	2019	Taste and odour (T&amp;O) compounds (most commonly 2-MIB and Geosmin) in drinking water are becoming an increasingly global problem for water management.	Water	136-141	MIB E3 ubiquitin protein ligase 1	Homo sapiens	53-56
12873071-11	2003	Two spoons of the commercial bleach was added to 200 mL of tap water.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
31260782-1	2019	To encapsulate and deliver poorly water-soluble drugs, castor oil/silica hybrid microparticles (HMP)s were synthesized.	Water	34-39	inner membrane mitochondrial protein	Homo sapiens	96-99
12931878-12	2003	These findings indicate that soil water potential and carrier solvent concentrations can impact the rate and extent to which RDX is attenuated in a surface soil.	Water	34-39	radixin	Homo sapiens	125-128
12861054-1	2003	Peroxiredoxin-3 (Prdx3) is a mitochondrial member of the antioxidant family of thioredoxin peroxidases that uses mitochondrial thioredoxin-2 (Trx2) as a source of reducing equivalents to scavenge hydrogen peroxide (H(2)O(2)).	Water	215-220	thioredoxin 1	Mus musculus	79-90
31071669-2	2019	However, the SVOC occurrence and influence of pipe materials on SVOC levels in the tap water have received little attention.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
12861054-1	2003	Peroxiredoxin-3 (Prdx3) is a mitochondrial member of the antioxidant family of thioredoxin peroxidases that uses mitochondrial thioredoxin-2 (Trx2) as a source of reducing equivalents to scavenge hydrogen peroxide (H(2)O(2)).	Water	215-220	thioredoxin 1	Mus musculus	127-138
12945141-2	2003	Spa treatment with mineral water Serebryany klyuch in combined therapy of chronic pyelonephritis is shown to relieve clinical symptoms, decontaminate urine completely in 88.6% cases, to eliminate signs of immunodeficiency and endotoxicosis and to produce a 25.6% decrease in the recurrences for the nearest 2 years.	Water	27-32	surfactant protein A2	Homo sapiens	0-3
31071669-7	2019	12 PCB congeners were detected in Hangzhou tap water samples, with hepta-CBs (68% of samples) as the most frequently detected PCBs.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
31071669-8	2019	Nearly all tap water samples contained measurable o, p"-DDE, p, p"-DDT, and p, p"-DDD, and  DDTs had significantly (p &lt; 0.05) higher concentrations than  HCHs.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
12834222-5	2003	Method detection limits were at sub-ppb level for pure water and sub-ppm level for tap water.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
31071669-9	2019	All target PAHs had high detection frequencies (&gt;72%) in tap water samples, with their mean concentrations in the range of 2.1-41 ng/L.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
31071669-10	2019	Tap water from steel pipes had relatively lower SVOC concentrations than that from either reinforced concrete, gray cast iron, or ductile iron pipes.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
31071669-11	2019	Although no carcinogenic risks originating from exposure to SVOCs through ingestion and bathing were observed, the tap water from steel pipes showed relatively low exposure risks than that from other materials.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
12814092-0	2003	Flushing wounds in children--is tap water OK?	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
31282670-7	2019	Based on quantitative analysis of the impact on OMP degradation from cosolutes (including Cl-, HCO3-, NOM) as well as pH and NH2Cl doses, we developed a kinetic model for the prediction of OMP degradation in complex water matrices.	Water	216-221	olfactory marker protein	Homo sapiens	48-51
12810377-1	2003	OBJECTIVE: To investigate the relationship between aquaporin-4 (AQP4) water channel expression in astrocytes and brain edema caused by glioma.	Water	70-75	aquaporin 4	Homo sapiens	51-62
12810377-1	2003	OBJECTIVE: To investigate the relationship between aquaporin-4 (AQP4) water channel expression in astrocytes and brain edema caused by glioma.	Water	70-75	aquaporin 4	Homo sapiens	64-68
31282670-7	2019	Based on quantitative analysis of the impact on OMP degradation from cosolutes (including Cl-, HCO3-, NOM) as well as pH and NH2Cl doses, we developed a kinetic model for the prediction of OMP degradation in complex water matrices.	Water	216-221	olfactory marker protein	Homo sapiens	189-192
12810377-3	2003	RESULTS: The water transport of the in vitro blood-brain barrier model from the luminal side to basolateral side was increased after coculture with glioma cells, which induced significantly decreased expression level of AQP4 in the astrocytes.	Water	13-18	aquaporin 4	Homo sapiens	220-224
31283199-10	2019	The integration of the wastewater systems with ultrafiltration, AOP, and RO was effective to reduce the toxicity to levels comparable to, or better than, tap water samples.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	154-157
31315941-5	2019	Second, Yorkie controls water tightness of tracheal tubes by transcriptional regulation of the delta-aminolevulinate synthase gene (Alas).	Water	24-29	yorkie	Drosophila melanogaster	8-14
12782495-10	2003	Incorporating tap water consumption showed a similar pattern of reduced cycle length with increasing TTHM exposure.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
31315941-5	2019	Second, Yorkie controls water tightness of tracheal tubes by transcriptional regulation of the delta-aminolevulinate synthase gene (Alas).	Water	24-29	Aminolevulinate synthase	Drosophila melanogaster	95-125
12774023-7	2003	Glucagon also significantly increased hepatocyte membrane water permeability by about 70%, which was inhibited by the water channel blocker dimethyl sulfoxide (DMSO).	Water	58-63	glucagon	Rattus norvegicus	0-8
31315941-5	2019	Second, Yorkie controls water tightness of tracheal tubes by transcriptional regulation of the delta-aminolevulinate synthase gene (Alas).	Water	24-29	Aminolevulinate synthase	Drosophila melanogaster	132-136
31048249-3	2019	Fluorescence titration experiments show that probe STH has an excellent linear relationship (R2=0.9694) with Al3+ concentration and could be applied to quantitatively recognize Al3+ in real-water samples.	Water	190-195	saitohin	Homo sapiens	51-54
12702742-7	2003	From our results we propose that KCNQ1 and KCNQ4 channels play an important role in cell volume control, e.g. during transepithelial transport of salt and water.	Water	155-160	potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog	Xenopus laevis	33-38
31095463-11	2019	The results from this study suggest that DSW could be a potential therapeutic agent for the prevention and treatment of diabetic cardiac hypertrophy.NEW &amp; NOTEWORTHY Deep sea water, containing high levels of minerals, improve cardiac hypertrophy in diabetic rats through attenuating the eccentric signaling pathway, IL-6-MEK5-STAT3, and concentric signaling pathway, IGF2-PKCalpha-CaMKII.	Water	179-184	insulin-like growth factor 2	Rattus norvegicus	371-375
12777181-11	2003	The factors most strongly associated with symptoms were drinking tap water (OR = 7.8, 95% CI 1.3-48), exposure to vapors from the basement (OR = 10.4, 2.3-47) and eating foods prepared with tap water (OR = 8.6, 1.9-40).	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
12777181-11	2003	The factors most strongly associated with symptoms were drinking tap water (OR = 7.8, 95% CI 1.3-48), exposure to vapors from the basement (OR = 10.4, 2.3-47) and eating foods prepared with tap water (OR = 8.6, 1.9-40).	Water	194-199	nuclear RNA export factor 1	Homo sapiens	190-193
16256541-3	2003	The presence of Mn(II) and Ca(II) ions alone led to a systematic reduction in zeta potential due to specific adsorption of positively charged metal ion-based hydrolysis products at the kaolinite-water interface.	Water	195-200	carbonic anhydrase 2	Homo sapiens	27-33
31095463-11	2019	The results from this study suggest that DSW could be a potential therapeutic agent for the prevention and treatment of diabetic cardiac hypertrophy.NEW &amp; NOTEWORTHY Deep sea water, containing high levels of minerals, improve cardiac hypertrophy in diabetic rats through attenuating the eccentric signaling pathway, IL-6-MEK5-STAT3, and concentric signaling pathway, IGF2-PKCalpha-CaMKII.	Water	179-184	protein kinase C, alpha	Rattus norvegicus	376-384
30731184-3	2019	It can easily be produced locally in small generators, and dissolved in tap water, and quickly transmits into ordinary O2 in the surrounding air.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
12594222-10	2003	Furthermore, expression of TRPM2-S inhibited susceptibility to cell death and onset of apoptosis induced by H(2)O(2) in cells expressing TRPM2-L.	Water	108-113	transient receptor potential cation channel subfamily M member 2	Homo sapiens	27-32
12712026-2	2003	The purpose of this study was to compare the infection rates of wounds irrigated with normal saline solution versus those of wounds irrigated with running tap water.	Water	159-164	nuclear RNA export factor 1	Homo sapiens	155-158
12712026-11	2003	Tap water and normal saline solution pressures and flow rates differed.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
30731184-13	2019	CONCLUSION: Ozonized tap water is an effective decontaminant of E. coli, and it could be an alternative to traditional alcohol-fluid hand disinfectants both in healthcare institutions and public places.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
12712026-13	2003	However, more wounds were located on the hand in the tap water group (21.3%; 95% confidence interval [CI] 16.3% to 27.1%) compared with those in the normal saline solution group (9.2%; 95% CI 5.9% to 13.4%).	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
12712026-16	2003	Tap water might be an effective alternative to normal saline solution for wound irrigation in children.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
15188474-0	2004	Modification of 2D water that contains hexameric units in chair and boat conformations--a contribution to the structural elucidation of bulk water.	Water	19-24	ataxin 1 like	Homo sapiens	68-72
15188474-0	2004	Modification of 2D water that contains hexameric units in chair and boat conformations--a contribution to the structural elucidation of bulk water.	Water	141-146	ataxin 1 like	Homo sapiens	68-72
31243724-10	2019	Moreover, alpha-amylase-treated maize flour resulted in a significant enhancement of the desired properties of maize flour, such as resistant starch content, amylose, milk absorption capacity, and iodine and fatty acid complexing ability, and a reduction in swelling power, water binding, oil absorption capacity, and in vitro digestibility compared to untreated maize flour.	Water	274-279	alpha-amylase	Zea mays	10-23
15190366-8	2004	Plants expressing the DREB1A gene demonstrated substantial resistance to water stress in comparison with checks under experimental greenhouse conditions, manifested by a 10-day delay in wilting when water was withheld.	Water	73-78	dehydration response element B1A	Arabidopsis thaliana	22-28
15190366-8	2004	Plants expressing the DREB1A gene demonstrated substantial resistance to water stress in comparison with checks under experimental greenhouse conditions, manifested by a 10-day delay in wilting when water was withheld.	Water	199-204	dehydration response element B1A	Arabidopsis thaliana	22-28
12727595-2	2003	Data from the literature were used to assign statistical distributions to swimming pool chloroform concentrations, frequency and duration of swimming, showering and bathing, and average tap water consumption.	Water	190-195	nuclear RNA export factor 1	Homo sapiens	186-189
31302805-5	2019	Treatment with Jeju ground water increased CD4+CD8- or CD4-CD8+ single-positive thymocytes.	Water	27-32	CD4 antigen	Mus musculus	43-46
15173392-4	2004	The present study evaluated the role of H(2)O(2) and the mitochondrial electron transport chain as a potential mechanism for the induction of HO-1 during copper deficiency.	Water	40-45	heme oxygenase 1	Rattus norvegicus	142-146
31302805-5	2019	Treatment with Jeju ground water increased CD4+CD8- or CD4-CD8+ single-positive thymocytes.	Water	27-32	CD4 antigen	Mus musculus	55-58
12628678-4	2003	In addition, the presence of one sugar moiety on C-7 doubled the water solubility versus that of paclitaxel.	Water	65-70	complement C7	Homo sapiens	49-52
30266601-3	2019	By contrast, activating neurotensin (Nts)-expressing LHA neurons (termed LHA Nts neurons) causes mice to immediately drink water with a delayed suppression of feeding.	Water	123-128	neurotensin	Mus musculus	24-35
15172059-1	2004	Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative surrogate end-point for investigating the efficacy of drug treatment or studying the temporal evolution of cerebral ischemia.	Water	55-60	antizyme inhibitor 2	Rattus norvegicus	93-96
15172059-2	2004	Methodology is described for estimating ischemic lesion volumes in a rat model of permanent middle cerebral artery occlusion (MCAO) based on absolute and percent-reduction threshold values of the water ADC at 3 h post-MCAO.	Water	196-201	antizyme inhibitor 2	Rattus norvegicus	202-205
12505866-9	2003	Levels of Fos-ir were highest in fluid-depleted rats that drank water and sodium.	Water	64-69	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	10-13
30266601-3	2019	By contrast, activating neurotensin (Nts)-expressing LHA neurons (termed LHA Nts neurons) causes mice to immediately drink water with a delayed suppression of feeding.	Water	123-128	neurotensin	Mus musculus	37-40
30266601-3	2019	By contrast, activating neurotensin (Nts)-expressing LHA neurons (termed LHA Nts neurons) causes mice to immediately drink water with a delayed suppression of feeding.	Water	123-128	neurotensin	Mus musculus	77-80
30266601-6	2019	Activation of LHA Nts neurons stimulated drinking in water-replete and dehydrated mice, indicating that these neurons are sufficient to promote water intake regardless of homeostatic need.	Water	53-58	neurotensin	Mus musculus	18-21
15169887-6	2004	Catalase, an H(2)O(2) scavenger, strongly suppresses LMP1-induced production of H(2)O(2), which results in a decrease in the expression of HIF-1 alpha induced by LMP1.	Water	13-18	PDZ and LIM domain 7	Homo sapiens	53-57
30266601-6	2019	Activation of LHA Nts neurons stimulated drinking in water-replete and dehydrated mice, indicating that these neurons are sufficient to promote water intake regardless of homeostatic need.	Water	144-149	neurotensin	Mus musculus	18-21
15169887-6	2004	Catalase, an H(2)O(2) scavenger, strongly suppresses LMP1-induced production of H(2)O(2), which results in a decrease in the expression of HIF-1 alpha induced by LMP1.	Water	13-18	PDZ and LIM domain 7	Homo sapiens	162-166
19379352-3	2003	METHODS: We prepared tissue plasminogen activator (tPA) from 50 mg lyophilized powder, which was diluted (1 mg/mL) in sterile water for injection.	Water	126-131	chromosome 20 open reading frame 181	Homo sapiens	21-49
19379352-3	2003	METHODS: We prepared tissue plasminogen activator (tPA) from 50 mg lyophilized powder, which was diluted (1 mg/mL) in sterile water for injection.	Water	126-131	chromosome 20 open reading frame 181	Homo sapiens	51-54
15169887-6	2004	Catalase, an H(2)O(2) scavenger, strongly suppresses LMP1-induced production of H(2)O(2), which results in a decrease in the expression of HIF-1 alpha induced by LMP1.	Water	80-85	PDZ and LIM domain 7	Homo sapiens	53-57
15169887-6	2004	Catalase, an H(2)O(2) scavenger, strongly suppresses LMP1-induced production of H(2)O(2), which results in a decrease in the expression of HIF-1 alpha induced by LMP1.	Water	80-85	PDZ and LIM domain 7	Homo sapiens	162-166
12643689-1	2003	For the highly selective and sensitive sensing of Hg2+ in water, a new design concept was realized where the selectivity of the probe"s binding site is amplified by electronic properties of the chromophore.	Water	58-63	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	50-53
30266601-7	2019	Interestingly, mice with activated LHA Nts neurons drank any fluid that was provided regardless of its palatability, but if given a choice they preferred water or palatable solutions over unpalatable (quinine) or dehydrating (hypertonic saline) solutions.	Water	154-159	neurotensin	Mus musculus	39-42
31180482-6	2019	N15 Cro makes fewer direct contacts and hydrogen bonds to bases, relying mostly on water-mediated and Van der Waals contacts to recognize the sequence.	Water	83-88	cro	Escherichia virus Lambda	4-7
31276397-5	2019	To distinguish between these two possibilities, we analyzed the D-O-D bending mode of the water molecule that deprotonates/relocates to become O6/Ox.	Water	90-95	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	143-148
15512981-8	2004	Exacerbation of EAU in both CD200KO mice and Lewis rats when CD200-CD200R interaction is blocked suggests that this could be an avenue for therapeutic intervention.	Water	16-19	CD200 receptor 1	Mus musculus	67-73
15203244-8	2004	The present results suggest roles for the NPY Y(2) receptor in the modulation of ethanol and water consumption.	Water	93-98	neuropeptide Y receptor Y2	Mus musculus	42-59
31152065-11	2019	A cyanamide soak of the Ddi2-T157V enzyme revealed cyanamide bound directly to the Zn2+ ion, having displaced the zinc-bound water molecule.	Water	125-130	cyanamide hydratase	Saccharomyces cerevisiae S288C	24-28
15033928-1	2004	Aquaporin-4 (AQP4) is the major water channel of the neuromuscular system, but its physiological function in both perivascular astrocytes and skeletal muscle sarcolemma is unclear.	Water	32-37	aquaporin 4	Mus musculus	0-11
15033928-1	2004	Aquaporin-4 (AQP4) is the major water channel of the neuromuscular system, but its physiological function in both perivascular astrocytes and skeletal muscle sarcolemma is unclear.	Water	32-37	aquaporin 4	Mus musculus	13-17
15033928-7	2004	Sarcolemma vesicles prepared from mdx mice revealed, in parallel with AQP4 disappearance from the plasma membrane, a strong reduction in water permeability compared with wild-type mice.	Water	137-142	aquaporin 4	Mus musculus	70-74
15033928-8	2004	Altogether, these results demonstrate high AQP4-mediated water permeability of the skeletal muscle sarcolemma.	Water	57-62	aquaporin 4	Mus musculus	43-47
15033928-9	2004	Expression of sarcolemmal AQP4 together with that of vascular AQP1 may be responsible for the fast water transfer from the blood into the muscle during intense activity.	Water	99-104	aquaporin 4	Mus musculus	26-30
30926390-7	2019	Impairment of pericyte-endothelium interaction increases the BBB permeability to water that is marked by a significant increase in aquaporin4 expression in injured animals.	Water	81-86	aquaporin 4	Mus musculus	131-141
30341500-5	2019	The shallowest borehole water (60 m bgl) was dominated by sulfur-oxidizing Epsilonproteobacteria (Sulfurimonas, Sulfurovum).	Water	24-29	LPS responsive beige-like anchor protein	Homo sapiens	36-39
15117337-10	2004	Our study supports the concept that ANP expressed in the SON acts as a peptidergic neurotransmitter involved in water and salt regulation during pregnancy and postpartum.	Water	112-117	natriuretic peptide A	Rattus norvegicus	36-39
15180341-4	2004	METHODS: A water-soluble, biodegradable triblock copolymer of poly [(DL-lactide-co-glycolide)-b-ethylene glycol-b-(DL-lactide-coglycolide)] (ReGel) was used in this study as an injectable formulation for controlled release of GLP-1.	Water	11-16	glucagon	Rattus norvegicus	226-231
30341500-7	2019	Sulfate reducers (members of Clostridia: Candidatus Desulforudis) were the most abundant bacteria in the deepest borehole water (660 m bgl).	Water	122-127	LPS responsive beige-like anchor protein	Homo sapiens	135-138
31242419-2	2019	Such plasticity is partly mediated by ion and water fluxes, which rely on the water channel aquaporin-4 (AQP4).	Water	46-51	aquaporin 4	Homo sapiens	92-103
15066944-7	2004	However, when ingested with 16 oz of room temperature tap water, phenylpropanolamine increased SBP by 82+/-2 mm Hg.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
31242419-2	2019	Such plasticity is partly mediated by ion and water fluxes, which rely on the water channel aquaporin-4 (AQP4).	Water	46-51	aquaporin 4	Homo sapiens	105-109
15070393-3	2004	The accepted mechanism for CAII would predict that water would be bound to the Zn(2+) at pH 5 and hydroxide would be bound at pH 8.5.	Water	51-56	carbonic anhydrase 2	Homo sapiens	27-31
31242419-2	2019	Such plasticity is partly mediated by ion and water fluxes, which rely on the water channel aquaporin-4 (AQP4).	Water	78-83	aquaporin 4	Homo sapiens	92-103
31242419-2	2019	Such plasticity is partly mediated by ion and water fluxes, which rely on the water channel aquaporin-4 (AQP4).	Water	78-83	aquaporin 4	Homo sapiens	105-109
31220136-0	2019	Increased cerebral vascularization and decreased water exchange across the blood-brain barrier in aquaporin-4 knockout mice.	Water	49-54	aquaporin 4	Mus musculus	98-109
15057194-3	2004	The Environmental Protection Agency (EPA) requires water authorities to test tap water in 10-100 residences annually for lead.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	77-80
14986129-1	2004	Guanylin-like peptides regulate electrolyte/water transport through the epithelia.	Water	44-49	guanylate cyclase activator 2A	Rattus norvegicus	0-8
31220136-1	2019	Aquaporin-4 (AQP4) plays an important role in regulating water exchange across the blood-brain barrier (BBB) and brain-cerebrospinal fluid interface.	Water	57-62	aquaporin 4	Mus musculus	0-11
14986129-8	2004	The guanylin immunoreactivity we detected in adult salivary duct cells accords with guanylin"s role in regulating electrolyte and water transport through the various epithelia.	Water	130-135	guanylate cyclase activator 2A	Rattus norvegicus	4-12
14986129-8	2004	The guanylin immunoreactivity we detected in adult salivary duct cells accords with guanylin"s role in regulating electrolyte and water transport through the various epithelia.	Water	130-135	guanylate cyclase activator 2A	Rattus norvegicus	84-92
31220136-1	2019	Aquaporin-4 (AQP4) plays an important role in regulating water exchange across the blood-brain barrier (BBB) and brain-cerebrospinal fluid interface.	Water	57-62	aquaporin 4	Mus musculus	13-17
31220136-10	2019	These results suggest that increased cerebral vascularization may be an adaptive response to chronic reduction in water exchange across BBB in AQP4-KO mice.	Water	114-119	aquaporin 4	Mus musculus	143-147
31258517-4	2019	After host cell invasion, mycobacteria induces the expression of NADPH oxidase 2 (NOX2) to generate superoxide radicals (  O 2 -   ), which are then converted to more toxic hydrogen peroxide (H2O2) by superoxide dismutase (SOD) and subsequently reduced to water by catalase.	Water	256-261	cytochrome b-245 beta chain	Homo sapiens	65-80
15070600-9	2004	In vitro HT29 culture cells subjected to a heated water bath exhibited a cellular sensitivity to heat and change of HSP expression similar to those in tumor xenografts subjected to RFA.	Water	50-55	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	116-119
15037522-5	2004	Intraluminal secretion of water is increased by NK2 receptor agonists via a direct effect on epithelial cells, and this mechanism is active in models of diarrhoea since selective antagonists reverse the increase in faecal water content in these models.	Water	26-31	tachykinin receptor 2	Homo sapiens	48-60
15037522-5	2004	Intraluminal secretion of water is increased by NK2 receptor agonists via a direct effect on epithelial cells, and this mechanism is active in models of diarrhoea since selective antagonists reverse the increase in faecal water content in these models.	Water	222-227	tachykinin receptor 2	Homo sapiens	48-60
31258517-4	2019	After host cell invasion, mycobacteria induces the expression of NADPH oxidase 2 (NOX2) to generate superoxide radicals (  O 2 -   ), which are then converted to more toxic hydrogen peroxide (H2O2) by superoxide dismutase (SOD) and subsequently reduced to water by catalase.	Water	256-261	cytochrome b-245 beta chain	Homo sapiens	82-86
31117367-0	2019	Cononsolvency of Elastin-like Polypeptides in Water/Alcohol Solutions.	Water	46-51	elastin	Homo sapiens	17-24
31117367-3	2019	The effect of solvent composition on the dilute solution phase behavior of an elastin-like polypeptide is studied here in water/alcohol blends that contain 0-40 vol % methanol, ethanol, isopropanol, or 1-propanol.	Water	122-127	elastin	Homo sapiens	78-85
31018474-6	2019	Subsequent analysis showed that the reaction of BDE-209 with GY1 was a detoxification process and bioaugmentation with GY1 effectively enhanced BDE-209 degradation in actual water and water-sediment system.	Water	174-179	homeobox D13	Homo sapiens	48-51
15152817-4	2004	METHODS: Three groups of Wistar rats fed a calculogenic diet (RC16) were treated with TRK-530 in drinking water at concentrations of 0 (control group), 0.75, and 1.5 mM.	Water	106-111	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	86-89
15152817-10	2004	However, subcutaneous injection of TRK-530 did not have any significant effect, suggesting that the anticalculus effect of TRK-530 in drinking water was topical, not systemic.	Water	143-148	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	123-126
31018474-6	2019	Subsequent analysis showed that the reaction of BDE-209 with GY1 was a detoxification process and bioaugmentation with GY1 effectively enhanced BDE-209 degradation in actual water and water-sediment system.	Water	174-179	DGCR8 microprocessor complex subunit	Homo sapiens	61-64
31018474-6	2019	Subsequent analysis showed that the reaction of BDE-209 with GY1 was a detoxification process and bioaugmentation with GY1 effectively enhanced BDE-209 degradation in actual water and water-sediment system.	Water	174-179	DGCR8 microprocessor complex subunit	Homo sapiens	119-122
15706878-3	2004	RESULT: Water-soluble fractions, total salvianolic acids and salvianolic acid B markedly decreased ACE activity of rabbit lung tissue.	Water	8-13	angiotensin-converting enzyme	Oryctolagus cuniculus	99-102
31018474-6	2019	Subsequent analysis showed that the reaction of BDE-209 with GY1 was a detoxification process and bioaugmentation with GY1 effectively enhanced BDE-209 degradation in actual water and water-sediment system.	Water	184-189	homeobox D13	Homo sapiens	48-51
31018474-6	2019	Subsequent analysis showed that the reaction of BDE-209 with GY1 was a detoxification process and bioaugmentation with GY1 effectively enhanced BDE-209 degradation in actual water and water-sediment system.	Water	184-189	DGCR8 microprocessor complex subunit	Homo sapiens	61-64
31018474-6	2019	Subsequent analysis showed that the reaction of BDE-209 with GY1 was a detoxification process and bioaugmentation with GY1 effectively enhanced BDE-209 degradation in actual water and water-sediment system.	Water	184-189	DGCR8 microprocessor complex subunit	Homo sapiens	119-122
15019077-7	2004	TPR factor was found to be dependent on particle size, particle surface, water absorption capacity and solubility of the excipient and model drug, respectively.	Water	73-78	translocated promoter region, nuclear basket protein	Homo sapiens	0-3
31117499-5	2019	Furthermore, C13-KR emulsifier could sharply reduce the interfacial tension and had the lowest tension value at the oil/water interface.	Water	120-125	homeobox C13	Homo sapiens	13-16
30879680-1	2019	One water-soluble polysaccharide (AAP), with a molecular weight of 6.3 x 104 Da, was isolated from Artemisia annua L. Structrual analysis indicated that AAP was found to be a 1, 3-alpha-linked and 1, 3, 6-alpha-linked Glcp backbone, with a branch of 1, 6-alpha-linked Glcp and terminal 1-linked-L-Rhap along the main chain in a ratio of 1: 1: 1: 1.	Water	4-9	serpin family F member 2	Homo sapiens	34-37
14675840-6	2004	These findings suggest that Guandu river watershed, the main source of urban drinking water supply in Rio de Janeiro, is polluted with CYP1A-inducing xenobiotics.	Water	41-46	cytochrome P450 1A	Oreochromis niloticus	135-140
30879680-1	2019	One water-soluble polysaccharide (AAP), with a molecular weight of 6.3 x 104 Da, was isolated from Artemisia annua L. Structrual analysis indicated that AAP was found to be a 1, 3-alpha-linked and 1, 3, 6-alpha-linked Glcp backbone, with a branch of 1, 6-alpha-linked Glcp and terminal 1-linked-L-Rhap along the main chain in a ratio of 1: 1: 1: 1.	Water	4-9	serpin family F member 2	Homo sapiens	153-156
31160309-2	2019	In a previous issue of Cancer Research, Simone and colleagues show that the two isoforms of the aquaporin-4 (AQP4) water channel may determine the fate of gliomas.	Water	115-120	aquaporin 4	Homo sapiens	96-107
14980701-3	2004	In this work we show that also metmyoglobin and methemoglobin can nitrate free tyrosine in the presence of nitrite and H(2)O(2).	Water	119-124	hemoglobin subunit gamma 2	Homo sapiens	48-61
31160309-2	2019	In a previous issue of Cancer Research, Simone and colleagues show that the two isoforms of the aquaporin-4 (AQP4) water channel may determine the fate of gliomas.	Water	115-120	aquaporin 4	Homo sapiens	109-113
30818190-5	2019	NP-PS system worked better in bottled water (96.46%) and tap water (85.14%) than river water (31.28%).	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
14992743-0	2004	Differential expression of neuronal fos protein after cold water drowning and controlled rewarming.	Water	59-64	protein c-Fos	Ovis aries	36-39
14750886-8	2004	Analysis of tap water, spiked with chloroform or carbon tetrachloride, gave recoveries within 1.0-2.6% of the recoveries by the standard GC method.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
30826705-8	2019	Third, compared with the iodoacetic acid sample and the simulated tap water sample without ammonolysis, the developmental toxicity of the corresponding samples with ammonolysis decreased by up to 10.4% and 32.1%, respectively.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
14607489-1	2004	In the conventional transesterification of fats/vegetable oils for biodiesel production, free fatty acids and water always produce negative effects, since the presence of free fatty acids and water causes soap formation, consumes catalyst and reduces catalyst effectiveness, all of which result in a low conversion.	Water	110-115	chromosome 10 open reading frame 90	Homo sapiens	43-47
14607489-1	2004	In the conventional transesterification of fats/vegetable oils for biodiesel production, free fatty acids and water always produce negative effects, since the presence of free fatty acids and water causes soap formation, consumes catalyst and reduces catalyst effectiveness, all of which result in a low conversion.	Water	192-197	chromosome 10 open reading frame 90	Homo sapiens	43-47
30826705-9	2019	The ammonolysis was thus demonstrated to be a detoxification process for both individual HAAs and DBP mixture in chlorinated tap water.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
30826705-10	2019	In practice, the ammonolysis of haloacid DBPs in tap water may be realized by simply adding an appropriate amount of an aminating agent during cooking.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
31054055-1	2019	Trihalomethanes (THMs) and adsorbable organic halides (AOX) were generated in chlorinated water.	Water	90-95	acyl-CoA oxidase 1	Homo sapiens	55-58
14758166-1	2004	OBJECTIVE: The aim of this study was to investigate the impact of the novel, potent, water-soluble inhibitor of poly(adenosine diphosphate-ribose) polymerase (PARP) 5-aminoisoquinolinone (5-AIQ) on hepatic microcirculation, hepatocellular injury, and survival in a murine model of hepatic ischemia-reperfusion.	Water	85-90	poly (ADP-ribose) polymerase family, member 1	Mus musculus	159-163
12553971-8	2003	The results indicated that equilibrium P concentration of the water column of the wetland would be above 1.3 mgL(-1), which is well above the targeted P level in the water column of the Lake Okeechobee, one of the main water bodies in the area (0.04 mg PL(-1)).	Water	62-67	LLGL scribble cell polarity complex component 1	Homo sapiens	109-115
31054055-2	2019	The purpose of the study was to provide a comprehensive picture of concentration distribution, the seasonal and different water source variability of THMs and AOX.	Water	122-127	acyl-CoA oxidase 1	Homo sapiens	159-162
31054055-12	2019	The levels of THMs and AOX in drinking water varied with different water sources and followed the order local reservoir &gt; Yellow River reservoir &gt; ground water.	Water	39-44	acyl-CoA oxidase 1	Homo sapiens	23-26
31054055-12	2019	The levels of THMs and AOX in drinking water varied with different water sources and followed the order local reservoir &gt; Yellow River reservoir &gt; ground water.	Water	67-72	acyl-CoA oxidase 1	Homo sapiens	23-26
14766955-4	2004	In nondiapausing pupae, the expression of two inducible Hsps (Hsp23 and Hsp70) is upregulated by desiccation, but the water loss threshold for Hsp expression changes at different rates of dehydration.	Water	118-123	Heat shock protein 23	Drosophila melanogaster	62-67
31054055-12	2019	The levels of THMs and AOX in drinking water varied with different water sources and followed the order local reservoir &gt; Yellow River reservoir &gt; ground water.	Water	67-72	acyl-CoA oxidase 1	Homo sapiens	23-26
12584172-9	2003	Treatment of AS52 cells with hydrogen peroxide (H(2)O(2), 100 micro M), ONOO(-) (100 micro M) and SIN-1 (100 micro M), a ONOO(-) generator, also increased the mutation frequency of the gpt gene (4.6-, 5.4- and 2.8-fold, respectively).	Water	48-53	alanine aminotransferase 1	Cricetulus griseus	185-188
30979398-9	2019	CONCLUSIONS: Fluoridated tap water is a low-cost, ecologically friendly resource that provides health benefits seldom found in bottled water.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
12631248-6	2003	In addition, enzyme activities for both tyrosine hydroxylase and tyrosinase were measured in the same preparations, by following the catalytic release of tritiated water from L-[3,5-3H]tyrosine.	Water	164-169	tyrosinase	Homo sapiens	65-75
14645499-1	2004	The human secretin receptor (hSR) is an important glycoprotein receptor for regulating the secretion of pancreatic bicarbonate, water, and electrolytes.	Water	128-133	HSR	Homo sapiens	29-32
14737648-1	2004	Gamma-glutamyl transpeptidase (GGT) catalyses the transfer of a gamma-glutamyl moiety from a donor substrate to different acceptors, such as amino acids and water.	Water	157-162	inactive glutathione hydrolase 2	Homo sapiens	0-29
14737648-1	2004	Gamma-glutamyl transpeptidase (GGT) catalyses the transfer of a gamma-glutamyl moiety from a donor substrate to different acceptors, such as amino acids and water.	Water	157-162	inactive glutathione hydrolase 2	Homo sapiens	31-34
30979398-9	2019	CONCLUSIONS: Fluoridated tap water is a low-cost, ecologically friendly resource that provides health benefits seldom found in bottled water.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	25-28
12636128-0	2003	Tap water filters.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
30979398-10	2019	However, mistrust about the quality and safety of tap water may make those in low-income communities more vulnerable to the effects of not receiving adequate fluoride and thus at higher risk of developing caries.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
12636128-1	2003	Moen PureTouch filters remove impurities from tap water without removing fluoride.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
30979398-11	2019	PRACTICAL IMPLICATIONS: Future interventions should encourage tap water use by dispelling misconceptions and educating low-income people in urban areas of LAC about the health benefits of fluoridated tap water and the safety of its sources.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
30979398-11	2019	PRACTICAL IMPLICATIONS: Future interventions should encourage tap water use by dispelling misconceptions and educating low-income people in urban areas of LAC about the health benefits of fluoridated tap water and the safety of its sources.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	200-203
14984209-1	2004	The hydration of CO2 catalyzed by human carbonic anhydrase II (HCA II) is accompanied by proton transfer from the zinc-bound water of the enzyme to solution.	Water	125-130	carbonic anhydrase 2	Homo sapiens	40-61
31218874-3	2019	After we confirmed that the estimated light production of the luminescence of water could adequately simulate the experimental results, we calculated the produced light photons of this luminescence and the CL from water for protons (170 MeV), carbon ions (330 MeV/n), high-energy x-ray (6 MV) from a linear accelerator (LINAC), high-energy electrons (9 MeV) from LINAC, positrons (F-18, C-11, O-15, and N-13), and high-energy gamma photon radionuclides (Co-60).	Water	78-83	RNA polymerase III subunit K	Homo sapiens	387-391
14705138-0	2004	Water maze learning and forebrain mRNA expression of the neural cell adhesion molecule L1.	Water	0-5	L1 cell adhesion molecule	Rattus norvegicus	57-89
12705354-3	2003	Tap water and mineral water were found to contain various amounts of NOx that were drastically reduced by treatment with a reverse osmosis column and remained in trace amounts after ion exchange column treatment.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
31095520-7	2019	Increasing reliance on tap water likely requires measuring and addressing secondary contamination found in distributional systems and premise plumbing, and more aggressive public education campaigns.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
12507754-2	2003	Alpha-hemolysin (alphaHL) is a cytotoxin secreted by Staphylococcus aureus that assembles from a water-soluble monomer to form a membrane-bound heptameric beta-barrel on the surface of susceptible cells, perforating the cell membranes, leading to cell death and lysis.	Water	97-102	AT695_RS11870	Staphylococcus aureus	0-15
15881783-3	2004	Special emphasis will be laid on the last experiment on space station MIR the goal of which was the determination of the depth distribution of absorbed dose and dose equivalent in a water filled Phantom.	Water	182-187	membrane associated ring-CH-type finger 8	Homo sapiens	70-73
12515584-0	2003	Endemic cryptosporidiosis and exposure to municipal tap water in persons with acquired immunodeficiency syndrome (AIDS): a case-control study.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
12515584-7	2003	In the multivariable analysis with adjustments for confounders, tap water consumption inside and outside the home at the highest exposure categories was associated with the occurrence of cryptosporidiosis (inside the home: odds ratio (OR), 6.76; 95% CI 1.37-33.5, and outside the home: OR 3.16; 95% CI 1.23-8.13).	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
12515584-8	2003	The PAF was 85%; that is, the proportion of cases of cryptosporidiosis in San Francisco AIDS patients attributable to tap water consumption could have been as high as 85%.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
30876577-2	2019	This probe selectively and quickly binds to Hg2+ and Cu2+ ions in CH3CN/H2O (5:1 v/v) and exhibits remarkably blue-shifted absorption and fluorescence bands due to the inhibition of the intramolecular charge transfer process.	Water	72-75	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	44-47
12564497-6	2003	The analysis was performed by performing five iterative simulations of the SAR pattern produced inside a tissue structure by a waveguide applicator with a water bolus containing the dynamic patch array attached.	Water	155-160	sarcosine dehydrogenase	Homo sapiens	75-78
14678792-0	2004	Structural studies of a Phe256Trp mutant of human salivary alpha-amylase: implications for the role of a conserved water molecule in enzyme activity.	Water	115-120	amylase alpha 1A	Homo sapiens	50-72
14678792-2	2004	In human salivary alpha-amylase (HSAmy), this water (W641), observed in many alpha-amylase structures, is part of a chain of water molecules.	Water	46-51	amylase alpha 1A	Homo sapiens	9-31
14678792-2	2004	In human salivary alpha-amylase (HSAmy), this water (W641), observed in many alpha-amylase structures, is part of a chain of water molecules.	Water	125-130	amylase alpha 1A	Homo sapiens	9-31
12514004-5	2003	When modifications were made in the elution and concentration steps to streamline the Filta-Max procedure, the mean percentages of recovery from filtered tap water were 40.2% +/- 16.3% for oocysts and 49.4% +/- 12.3% for cysts by the modified procedures, while matrix spike oocyst recovery percentages ranged from 2.1 to 36.5% and cyst recovery percentages ranged from 22.7 to 68.3%.	Water	158-163	nuclear RNA export factor 1	Homo sapiens	154-157
31055909-2	2019	The exfoliated nanostructures (Alk-Ti2Cfibr and Alk-Ti2Csheet) with exceptional mechanical, thermal, and water stabilites, as well as abundant oxygenated active binding sites, were synthesized via a controlled hydrothermal treatment in an alkaline environment.	Water	105-110	ALK receptor tyrosine kinase	Homo sapiens	31-34
12680195-0	2003	Radiochemical investigations of [188Re(H2O)(CO)3-diaminopropionic acid-SSS-bombesin(7-14)NH2]: syntheses, radiolabeling and in vitro/in vivo GRP receptor targeting studies.	Water	39-42	gastrin releasing peptide	Homo sapiens	75-83
14695256-6	2004	We found that, for equivalent cation or glucose uptakes, the combination of substrate accumulations observed with ROMK2 and GLUT2 are sufficient to provide the osmotic gradient necessary to account for a passive water flux through SGLT1.	Water	212-217	solute carrier family 5 (sodium/glucose cotransporter), member 1, gene 2 L homeolog	Xenopus laevis	231-236
12548407-1	2003	Uroguanylin, a peptide hormone highly expressed in the gastrointestinal tract, is implicated in the regulation of epithelial salt and water transport processes.	Water	134-139	guanylate cyclase activator 2B	Homo sapiens	0-11
31055909-2	2019	The exfoliated nanostructures (Alk-Ti2Cfibr and Alk-Ti2Csheet) with exceptional mechanical, thermal, and water stabilites, as well as abundant oxygenated active binding sites, were synthesized via a controlled hydrothermal treatment in an alkaline environment.	Water	105-110	ALK receptor tyrosine kinase	Homo sapiens	48-51
15007904-0	2004	[Volatile organic compounds of the tap water in the Watarase, Tone and Edo River system].	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
30933476-5	2019	The outcomes revealed that the AuNPs could improve the acquisition and retention of spatial learning and memory in Abeta treated rats as indicated by decreased time (Abeta: 39.60 +- 3.23 s vs Abeta+AuNPs: 25.78 +- 2.80 s) and distance (Abeta: 917.98 +- 50.81 cm vs Abeta+AuNPs: 589.09 +- 65.96 cm) of finding the hidden platform during training days and by increased time spent in the target quadrant (Abeta: 19.40 +- 0.98 s vs Abeta+AuNPs: 29.36 +- 1.14 s) in the probe test in Morris water maze (MWM).	Water	486-491	amyloid beta precursor protein	Rattus norvegicus	115-120
15007904-10	2004	RESULTS: Concentrations of THMs in the downstream tap water samples were higher than those in the samples from the upperstream.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
15007904-12	2004	In tap water of local government C, trichloroethylene was detected.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
12580260-3	2003	EO water completely eliminated all Staphylococcus aureus on 12, 11, 12, and 11 out of 15 eggs in Rep 1, 2, 3, and 4, respectively.	Water	3-8	replication protein	Staphylococcus aureus	97-115
14691275-1	2004	AIMS: To assess spatial fluctuations, temporal variability, and errors due to sampling and analysis in levels of disinfection by-products in routine monitoring tap water samples and in water samples collected in households within the same distribution system for an exposure assessment study.	Water	164-169	nuclear RNA export factor 1	Homo sapiens	160-163
31091829-0	2019	Assessment of Groundwater Quality in CKDu Affected Areas of Sri Lanka: Implications for Drinking Water Treatment.	Water	97-102	sorcin	Homo sapiens	60-63
15200272-1	2004	Aquaporin 4 (AQP4) is a water channel protein that is widely distributed in human tissues.	Water	24-29	aquaporin 4	Homo sapiens	0-11
15015270-4	2003	RESULT: The water extract of Musk at dose of 5, 20, 80 mg.kg-1 (s.c.) significantly inhibited the chemotaxis of PMN in rat; Musk-1 at concentration of 1-100 micrograms.mL-1 can significantly inhibit the chemotaxis of rabbit PMN in vitro; Musk-1 at concentration of 1-100 micrograms.mL-1 can significantly inhibit the increase of cytosolic Ca2+ concentration in PMN of rat.	Water	12-17	LOW QUALITY PROTEIN: muscle, skeletal receptor tyrosine-protein kinase	Oryctolagus cuniculus	124-128
12607622-6	2002	Water specimens were collected from the triple syringe, high speed outlet, cup filler and surgery tap.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	98-101
15200272-1	2004	Aquaporin 4 (AQP4) is a water channel protein that is widely distributed in human tissues.	Water	24-29	aquaporin 4	Homo sapiens	13-17
30876951-7	2019	For 5P12-RANTES, sustained release was obtained for 31 days using water vapor annealing.	Water	66-71	C-C motif chemokine ligand 5	Homo sapiens	9-15
31049707-8	2019	Graphical abstract By using ultrastable and positively charged gold nanoparticles as fluorescence quenchers and exonuclease assisted signal amplification, a method is developed for the sensitive and selective detection of Hg2+ in water samples.	Water	230-235	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	222-225
15633633-10	2004	PB1 was a solid with metallic appearance; it was water soluble and its two dimensional chromatography showed 9 spots.	Water	49-54	polybromo 1	Homo sapiens	0-3
12450933-9	2002	In parallel, DS-1 decreased the accumulation of extravascular lung water by 60-70% and reduced the increment in right ventricle stroke work index and the falls in right ventricle ejection fraction, stroke volume, and left ventricle stroke work indices.	Water	67-72	mitochondrial ribosomal protein L58	Homo sapiens	13-17
30903353-0	2019	Selective, Sensitive and Label-Free Detection of Fe3+ Ion in Tap Water Using Highly Fluorescent Graphene Quantum Dots.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
12470971-8	2002	The positional dependence of T(2) relaxation times as well as that of M(2) indicated that they represent the behavior of the bound water in the lens.	Water	131-136	solute carrier family 25 member 5	Homo sapiens	29-33
12463253-1	2002	The performance of the OC2 Sea-viewing Wide Field-of-view Sensor (SeaWiFS) algorithm based on 490- and 555-nm water-leaving radiances at low chlorophyll contents is compared with those of semianalytical models and a Monte Carlo radiative transfer model.	Water	110-115	one cut homeobox 2	Homo sapiens	23-26
14978297-4	2004	As is known, some kinds of mineral waters contain naturally occurring radionuclides in higher concentration than the usual drinking (tap) water.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	133-136
30903353-7	2019	Importantly, the new sensor realizes the detection of Fe3+ ions in tap water because of its low detection limit, wide linear range, and high sensitivity.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
30506959-2	2019	METHODS: For b-values larger than about 4000 s/mm2 , the direction-averaged diffusion MRI signal from white matter is dominated by the contribution from water within axons, which enables T2a to be estimated by acquiring data for multiple TE values and fitting a mono-exponential decay curve.	Water	153-158	PNMA family member 2	Homo sapiens	47-50
15237632-0	2004	The effect of water quality and NOM character on the ozonation of MIB and geosmin.	Water	14-19	MIB E3 ubiquitin protein ligase 1	Homo sapiens	66-69
30895967-5	2019	RESULTS: The median level of continuous airway pressure (CPAP) used during the transfer was 7 cm H2O (6-7.25).	Water	97-100	centromere protein J	Homo sapiens	57-61
15237641-1	2004	Chlorinous flavors at the tap are the leading cause of customers" complaints and dissatisfaction with drinking water.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	26-29
15537002-2	2004	In the subsequent treatment steps of washing with tap water, ammonium removed from urine was eluted from the surface of the clinoptilolite to be recovered for further reuse.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
30819802-0	2019	The disordered plant dehydrin Lti30 protects the membrane during water-related stress by cross-linking lipids.	Water	65-70	dehydrin family protein	Arabidopsis thaliana	30-35
15537002-6	2004	The recovery was calculated as 9.73 mg ammonium per gram of clinoptilolite, corresponding to an efficiency of 63% only through washing with tap water.	Water	144-149	nuclear RNA export factor 1	Homo sapiens	140-143
14647152-8	2003	Switching on expression of TRAIL by adding tetracycline to the drinking water of the mice strongly reduced tumour growth by apoptosis in a caspase-dependent manner.	Water	72-77	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	27-32
30580164-7	2019	Overall, the quantitative findings suggested that the occurrence of non-nutritive artificial sweeteners is present in surface water, tap water, groundwater, seawater, lakes and atmosphere.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
14645363-5	2003	The following hypothesis is proposed: in astrocytes, under normal conditions, AQP4 couples water transport with Kir4.1 mediated K+ siphoning, but in pathological states, AQP4 facilitates the flow of brain oedema fluid, and Kir4.1 buffers increased extracellular K+.	Water	91-96	aquaporin 4	Homo sapiens	78-82
30978967-4	2019	Employing human blood-based in vitro tests, the LPS isolated from complex water bloom revealed the priming of both major blood phagocyte population monocytes and polymorphonuclear leukocytes documented by the increased surface expression of CD11b and CD66b.	Water	74-79	integrin subunit alpha M	Homo sapiens	241-246
14750691-6	2003	Tap water in the capital Amman, where approximately 35% of the population live, has a very low radon concentration, 3.9 Bq l(-1).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
30535556-6	2019	Tap water will not supercool because it contains impurities that serve as nucleation sites for crystallization.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
14611901-3	2003	Cirrhosis was induced in mice by treatment with carbon tetrachloride (CCl4) intraperitoneally with 5% alcohol in drinking water for 12 weeks.	Water	122-127	chemokine (C-C motif) ligand 4	Mus musculus	70-74
30684007-7	2019	We showed that MLC1 and GlialCAM were enriched and assembled into mature complexes in astrocyte perivascular endfeet between postnatal days 10 and 15, after the formation of astrocyte perivascular Aquaporin 4 water channels.	Water	209-214	hepatic and glial cell adhesion molecule	Homo sapiens	24-32
14597700-1	2003	Osmotic homeostasis in the brain involves movement of water through aquaporin-4 (AQP4) membrane channels.	Water	54-59	LOW QUALITY PROTEIN: aquaporin-4	Cricetulus griseus	68-79
30684007-7	2019	We showed that MLC1 and GlialCAM were enriched and assembled into mature complexes in astrocyte perivascular endfeet between postnatal days 10 and 15, after the formation of astrocyte perivascular Aquaporin 4 water channels.	Water	209-214	aquaporin 4	Homo sapiens	197-208
14597700-1	2003	Osmotic homeostasis in the brain involves movement of water through aquaporin-4 (AQP4) membrane channels.	Water	54-59	LOW QUALITY PROTEIN: aquaporin-4	Cricetulus griseus	81-85
30732813-4	2019	Such unique structure endows GONS/CNF nanocomposites with ultrahigh oxygen barrier property and good water vapor barrier performance.	Water	101-106	NPHS1 adhesion molecule, nephrin	Homo sapiens	34-37
14597704-10	2003	These studies lead us to propose that water flux through perivascular AQP4 is needed to sustain efficient removal of K+ after neuronal activation.	Water	38-43	aquaporin 4	Mus musculus	70-74
30771559-1	2019	INTRODUCTION: Improving children"s tap water intake and reducing sugar-sweetened beverage (SSB) consumption is beneficial for health and health equity, particularly in low-income communities and communities of color.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
14616463-3	2003	The first group of 10 subjects drank 500 mL of cranberry juice diluted with 1500 mL tap water for 2 weeks, while the second group drank 2000 mL of tap water for the same period.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
30771559-2	2019	Existing community level interventions to improve the intake of tap water have predominantly occurred in schools and have focused on promoting water consumption in cafeterias during lunch or snack periods.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
30771559-3	2019	METHODS: The "Hydrate Philly" intervention was developed to target multiple environmental and social factors to improve tap water consumption in community recreation centers in low-income communities: replacing old and unappealing water fountains with appealing water-bottle-filling "hydration stations", conducting water safety testing and publicizing results, disseminating reusable water bottles, promoting tap water, and discouraging SSB consumption.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
14569179-0	2003	Trihalomethane levels in home tap water and semen quality.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
30771559-7	2019	DISCUSSION: Multilevel approaches are needed to increase tap water intake and decrease SSB consumption among low-income and minority youth beyond school and meal settings.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
14641596-9	2003	Pore water and rock geochemical analyses suggest that these SRB"s may have been sustained by sulphate diffusing from the adjacent U-rich, Carbon Leader where it was formed by radiolysis of sulphide.	Water	5-10	chaperonin containing TCP1 subunit 4	Homo sapiens	60-63
14658794-4	2003	Z-(Aib)11-OtBu crystallizes readily from hot ethanol-water mixture and is one of the crystals in which no solvent molecule is co-crystallized.	Water	53-58	ANIB1	Homo sapiens	3-6
12912993-2	2003	Annexin IV modifies membrane bilayers by increasing rigidity, reducing water and H+ permeability, promoting vesicle aggregation, and regulating ion conductances, all in a Ca2+-dependent manner.	Water	71-76	annexin A4	Mus musculus	0-10
14692686-0	2003	Immunolocalization of the water channel, aquaporin-5 (AQP5), in the rat digestive system.	Water	26-31	aquaporin 5	Rattus norvegicus	41-52
14692686-0	2003	Immunolocalization of the water channel, aquaporin-5 (AQP5), in the rat digestive system.	Water	26-31	aquaporin 5	Rattus norvegicus	54-58
14692686-14	2003	AQP5 appears to play an important role in water transfer in these glands.	Water	42-47	aquaporin 5	Rattus norvegicus	0-4
14626901-2	2003	Concentrations of DBPs (mean +/- standard deviation) in tap water were the following: total trihalomethanes (THMs) 205 +/- 70 micrograms/l, five haloacetic acids (HAAs) 150 +/- 30 micrograms/l, and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (mutagen X or MX) 160 +/- 50 ng/l.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
14626901-4	2003	The mutagenic activity of tap water extracts in the Salmonella TA-100 assay was 14,900 net revertants/l.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
14626901-8	2003	Due to concerns over microbiological safety of water, average daily consumption of non-boiled tap water in pregnant women was only 0.01 l/day, while consumption of boiled tap water was 0.81 l/day.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
14626901-8	2003	Due to concerns over microbiological safety of water, average daily consumption of non-boiled tap water in pregnant women was only 0.01 l/day, while consumption of boiled tap water was 0.81 l/day.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
14526231-0	2003	Differential effects of atrial natriuretic peptide on the brain water and sodium after experimental cortical contusion in the rat.	Water	64-69	natriuretic peptide A	Rattus norvegicus	24-50
14526231-1	2003	Atrial natriuretic peptide (ANP) plays an important role in the regulation of water and sodium in the body via cyclic GMP (cGMP) pathway.	Water	78-83	natriuretic peptide A	Rattus norvegicus	0-26
12972265-3	2003	Here, we use the magnetic relaxation dispersion (MRD) of the water 17O resonance to investigate the water molecules in the binding cavity of three different lipid-binding proteins: heart fatty acid-binding protein (H-FABP), ileal lipid-binding protein (I-LBP) and intestinal fatty acid-binding protein (I-FABP).	Water	100-105	fatty acid binding protein 6	Homo sapiens	253-258
12927985-2	2003	This device provides hot water and potable cool water directly from the faucets thus removing the need to refill the container or boil water separately in a kettle.	Water	25-30	alcohol dehydrogenase iron containing 1	Homo sapiens	21-24
16450544-3	2003	Slides washed in untreated tap water showed the best results concerning differentiation and colour intensity, while slides washed with softened or other treated water showed poorer degrees of differentiation and colour intensity.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
12838423-1	2003	The expression and localization of aquaporins (AQP1-AQP5), members of the water channel family, in the developing rat submandibular gland were analysed using RT-PCR, Northern blotting and immunohistochemistry to explore their relation to the development of this salivary gland.	Water	74-79	aquaporin 5	Rattus norvegicus	52-56
12783871-1	2003	The membrane water channel aquaporin 5 (AQP5) plays an important role in transporting water across the apical surface of the alveolar epithelium and the epithelia of submucosal glands in the upper airway and nasopharynx.	Water	13-18	aquaporin 5	Mus musculus	27-38
12783871-1	2003	The membrane water channel aquaporin 5 (AQP5) plays an important role in transporting water across the apical surface of the alveolar epithelium and the epithelia of submucosal glands in the upper airway and nasopharynx.	Water	13-18	aquaporin 5	Mus musculus	40-44
12783871-1	2003	The membrane water channel aquaporin 5 (AQP5) plays an important role in transporting water across the apical surface of the alveolar epithelium and the epithelia of submucosal glands in the upper airway and nasopharynx.	Water	86-91	aquaporin 5	Mus musculus	27-38
12783871-1	2003	The membrane water channel aquaporin 5 (AQP5) plays an important role in transporting water across the apical surface of the alveolar epithelium and the epithelia of submucosal glands in the upper airway and nasopharynx.	Water	86-91	aquaporin 5	Mus musculus	40-44
12873729-1	2003	The effects of water deprivation and chronic salt loading on the expression of the brain-derived neurotrophic factor (BDNF) gene were examined in the rat subfornical organ (SFO), using immunohistochemistry for BDNF and in situ hybridization histochemistry.	Water	15-20	brain-derived neurotrophic factor	Rattus norvegicus	83-116
12873729-2	2003	Increased BDNF-like immunoreactivity was observed in the SFO after water deprivation for 4 days.	Water	67-72	brain-derived neurotrophic factor	Rattus norvegicus	10-14
12890864-5	2003	The substrate specificity of MTMR7 is different than other MTM proteins in that this enzyme prefers the water-soluble substrate.	Water	104-109	myotubularin related protein 7	Mus musculus	29-34
12757791-8	2003	The estimated levels of hydrogen sulfide just above the water surface were plotted for the most polluted stagnant water body in Sri Lanka for the pH range of 5-10 and temperature range of 25-35 degrees C.	Water	56-61	sorcin	Homo sapiens	128-131
12846731-4	2003	The recordings were continuously made for 3 h after the ingestion of 100 mL of tap water with (16 subjects) or without (eight subjects) 10 g of lactulose.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
12964775-2	2003	Terpolymer poly(IPAAm-co-AAc-co-tBAAm) showed both phase transition and apparent carboxylate pKa shifts in water, depending on temperature.	Water	107-112	glycine-N-acyltransferase	Homo sapiens	25-28
14677264-4	2003	Tap water should be preferred to mineral water usually in stores.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
12738259-15	2003	Our research on AOX in interstitial water of anaerobic limnic sediments has led to the role of bromine playing in the diagenesis of the organic matter of sediments.	Water	36-41	acyl-CoA oxidase 1	Homo sapiens	16-19
12730618-2	2003	GSTZ1-1 is inactivated by dichloroacetic acid (DCA), which is used for the clinical management of congenital lactic acidosis and is a drinking-water contaminant.	Water	143-148	glutathione S-transferase zeta 1	Rattus norvegicus	0-7
12854693-0	2003	Copper concentrations in tap water and possible effects on infant"s health--results of a study in Lower Saxony, Germany.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
12858392-7	2003	This method was applied to determine haloacetic acids in tap water by combination with liquid-liquid extraction and back-extraction into NaOH solution.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
12872527-0	2003	A tap water turbidity crisis in Tel Aviv, Israel, due to technical failure: toxicological and risk management issues.	Water	6-11	nuclear RNA export factor 1	Homo sapiens	2-5
12793520-1	2003	Apelin, the endogenous peptide ligand of the APJ receptor, is expressed in brain regions implicated in food and water intake.	Water	112-117	apelin	Rattus norvegicus	0-6
12872403-5	2003	RESULTS: The cardiac function and coronary flow of isolated heart preserved in JSI containing mEC was significantly better than those in the control (P &lt; 0.01), with the LDH, CK activity and MDA content significantly lower (P &lt; 0.01 and P &lt; 0.05), SOD activity significantly higher (P &lt; 0.05) and pathologic injury milder than those in control, but comparison of cardiac water content between the two groups showed insignificant difference.	Water	383-388	chemokine (C-C motif) ligand 28	Mus musculus	94-97
12709690-1	2003	BACKGROUND: Secretin, a 27 amino acid polypeptide released in response to duodenal luminal acidification, stimulates secretion of water and bicarbonate from pancreatic ductal cells.	Water	130-135	secretin	Homo sapiens	12-20
12670265-2	2003	The observed longitudinal and transverse relaxivities for water protons, r(1) and r(2), of the metallofullerenols are in the range 0.8-73 and 1.2-80 (sec(-1)mM(-1)), respectively, which are significantly higher than those of the corresponding lanthanoid-DTPA chelate complexes.	Water	58-63	secretory blood group 1, pseudogene	Homo sapiens	150-156
12725389-5	2003	The solid-phase recovery rates of ten pesticides spiked into tap water and raw water were in the range of 69-111%.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
12641613-1	2003	Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Conwy County, North Wales, UK.	Water	51-56	surfactant protein A2	Homo sapiens	0-3
12654292-7	2003	In the absence of T1alpha protein, type I cell differentiation is blocked, as indicated by smaller airspaces, many fewer attenuated type I cells, and reduced levels of aquaporin-5 mRNA and protein, a type I cell water channel.	Water	212-217	aquaporin 5	Mus musculus	168-179
12595141-0	2002	Improvement of drought tolerance in maize: towards the functional validation of the Zm-Asr1 gene and increase of water use efficiency by over-expressing C4-PEPC.	Water	113-118	phosphoenolpyruvate carboxylase 1	Zea mays	156-160
12595141-5	2002	The highest C(4)-PEPC overexpressing line exhibited an increase (+30%) in intrinsic water use efficiency (WUE) accompanied by a dry weight increase (+20%) under moderate drought conditions.	Water	84-89	phosphoenolpyruvate carboxylase 1	Zea mays	17-21
12433160-3	2002	Over-water concentrations of gaseous Hg2+ were estimated from total gaseous Hg (TGM) concentrations measured at five sites in the basin and used to model dry deposition fluxes of Hg2+.	Water	5-10	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	37-40
12397274-7	2002	In the test group, water from the hot water tap at approximately body temperature was instilled into the colon by means of the accessory channel of the colonoscope with a 30 mL syringe.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	44-47
12413214-3	2002	Acrylic columns packed with chitosan and zeolite-sewage sludge mixtures in optimum ratio 1.0:10 and 3.0:10, respectively, were leached with tap water and sewage effluent at different pH levels.	Water	144-149	nuclear RNA export factor 1	Homo sapiens	140-143
12405647-4	2002	BCM was estimated from intracellular water measured by multiple dilution.	Water	37-42	TNF receptor superfamily member 17	Homo sapiens	0-3
12418662-4	2002	For the water sample whose adsorption capacity was least affected by Ca(II), the effect of pH was subsequently examined for four water pH levels (pH = 5.5-10) and these three ACs.	Water	8-13	carbonic anhydrase 2	Homo sapiens	69-75
12369811-0	2002	Fourth ventricular CART reduces food and water intake and produces a conditioned taste aversion in rats.	Water	41-46	CART prepropeptide	Rattus norvegicus	19-23
12369811-3	2002	CART reduced 30-min intakes of both water and Ensure at a threshold of 1 microg.	Water	36-41	CART prepropeptide	Rattus norvegicus	0-4
12394948-5	2002	INTERVENTIONS: P. aeruginosa also was found in 150 of 259 (58%) tap water samples taken from patient rooms.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
12394948-13	2002	CONCLUSIONS: Tap water from faucets contaminated with P. aeruginosa plays an important role in the propagation of this pathogen among patients.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
12362104-10	2002	Also, the median number of phases III per hour with CHO was higher than with tap water (0.4 v. 0.0; P &lt; 0.05).	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
12235094-0	2002	Motilin agonists and dyspepsia: throwing out the baby with the bath water.	Water	68-73	motilin	Homo sapiens	0-7
12237769-0	2002	A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin.	Water	50-55	choline phosphotransferase 1	Homo sapiens	43-46
12193653-4	2002	Overexpressing cells (C17 or C48) degraded H(2)O(2) and t-butylhydroperoxide more rapidly and showed decreased sensitivity to oxidant stress as measured by (51)Cr release.	Water	43-48	CDK5 regulatory subunit associated protein 2	Homo sapiens	29-32
12216046-1	2002	This study was designed to compare the infection rates of simple lacerations irrigated with tap water versus sterile normal saline before repair.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
12201134-0	2002	High-yield, low-pressure [18O] water targets of titanium and niobium for F-18 production on MC-17 cyclotrons.	Water	31-36	mastermind like domain containing 1	Homo sapiens	73-77
12357265-5	2002	AQP4 is expressed in astrocyte foot processes near capillaries and in ependymal cells lining the ventricles -- key sites for water movement between the cellular, vascular, and ventricular compartments.	Water	125-130	aquaporin 4	Mus musculus	0-4
12463138-4	2002	After studying their composition and adapting the dietary advice (particularly concerning dairy foods) to this ionic composition, various types of water can be advised to patients, including tap water, most types of spring water, but not all mineral waters.	Water	147-152	nuclear RNA export factor 1	Homo sapiens	191-194
12239573-0	2002	Reducing bacterial counts in dental unit waterlines: tap water versus distilled water.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
12239573-5	2002	RESULTS: The microbial plate counts of seven tap water specimens (controls) ranged from 4 to 95 CFU/mL.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
12198191-8	2002	Functional expression of HvPIP2;1 in Xenopus oocytes confirmed that HvPIP2;1 encoded an aquaporin that transports water.	Water	114-119	HvPIP2;1	Hordeum vulgare	25-33
12198191-8	2002	Functional expression of HvPIP2;1 in Xenopus oocytes confirmed that HvPIP2;1 encoded an aquaporin that transports water.	Water	114-119	HvPIP2;1	Hordeum vulgare	68-76
12012348-7	2002	However, once the degree of hydration exceeded that of elastin in pure water, no further decrease in stiffness was obtained despite continued increase in swelling.	Water	71-76	elastin	Homo sapiens	55-62
12039847-4	2002	Recently, we have reported that the expression of aquaporin-4 (AQP4), a water-selective channel expressed in the sarcolemma of fast-twitch fibers and astrocyte end-feet, is drastically reduced in the muscle and brain of the mdx mouse, the animal model of DMD.	Water	72-77	aquaporin 4	Mus musculus	50-61
12039847-4	2002	Recently, we have reported that the expression of aquaporin-4 (AQP4), a water-selective channel expressed in the sarcolemma of fast-twitch fibers and astrocyte end-feet, is drastically reduced in the muscle and brain of the mdx mouse, the animal model of DMD.	Water	72-77	aquaporin 4	Mus musculus	63-67
12369053-9	2002	In the past, the European Pharmacopoeia and the Italian Health Ministry released some reference values for tap water, values which were extended to water used for dialysis.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
12096052-9	2002	We conclude that the transport parameters derived for water cotransport by the SGLT1 can be attributed to the protein residing in the plasma membrane with no significant influences from unstirred layer effects.	Water	54-59	solute carrier family 5 (sodium/glucose cotransporter), member 1, gene 2 L homeolog	Xenopus laevis	79-84
12100915-14	2002	Tap water, however, can change urinary electrolytes in patients who form calcium stones.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
19750747-2	2002	Angiotensin-converting enzyme (ACE) inhibitors are commonly administered when hypertension is present to decrease plasma concentrations of angiotensin II and aldosterone, which cause vasoconstriction and sodium and water retention, respectively.	Water	215-220	angiotensin I converting enzyme	Felis catus	0-29
19750747-2	2002	Angiotensin-converting enzyme (ACE) inhibitors are commonly administered when hypertension is present to decrease plasma concentrations of angiotensin II and aldosterone, which cause vasoconstriction and sodium and water retention, respectively.	Water	215-220	angiotensin I converting enzyme	Felis catus	31-34
29900558-0	2019	Overexpression of TaCML20, a calmodulin-like gene, enhances water soluble carbohydrate accumulation and yield in wheat.	Water	60-65	CaM5	Triticum aestivum	29-39
12193876-17	2002	Water flows into principal cells from collecting duct lumen through AQP2 and flows out to interstitium through AQP3 and AQP4 and finally reachs blood circulation through AQP1 capillaries.	Water	0-5	aquaporin 4	Homo sapiens	120-124
12039784-0	2002	Identification of nontuberculous mycobacteria existing in tap water by PCR-restriction fragment length polymorphism.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
12039784-2	2002	Using acid-fast staining, culture, and PCR, acid-fast bacilli were detected in 83.7% of 49 hospital tap water samples and nontuberculous mycobacteria (NTM) were detected in 20.4% of the same 49 samples.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
31033226-8	2019	Instead, water restriction-activated NFAT5 associated with inhibition of SHP-1 in the SCD mice.	Water	9-14	nuclear factor of activated T cells 5	Mus musculus	37-42
12039784-4	2002	Our findings indicate that NTM in hospital tap water are the possible cause of false positives in acid-fast staining and of nosocomial infection in immunocompromised patients.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
12775361-2	2003	Adenosine deaminase (AD) is a marker of T-cell activation and is related to the production of reactive oxygen species by neutrophils with the production of NO(*), O(2)(*-), H(2)O(2) and OH(*).	Water	173-178	adenosine deaminase	Homo sapiens	0-19
31033226-8	2019	Instead, water restriction-activated NFAT5 associated with inhibition of SHP-1 in the SCD mice.	Water	9-14	nuclear receptor subfamily 0, group B, member 2	Mus musculus	73-78
12629252-0	2003	Peri-ictal water drinking lateralizes seizure onset to the nondominant temporal lobe.	Water	11-16	perilipin 1	Homo sapiens	0-4
11983278-4	2002	UDP-glucuronosyltransferase (UDP-GT) activities towards p-nitrophenol were markedly increased (51.8% or 1.5-fold) in rats that consumed tea compared with the control animals on water.	Water	177-182	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	0-27
31033226-11	2019	However, under water restriction, SCD mice struggle to concentrate urine despite activating NFAT5.	Water	15-20	nuclear factor of activated T cells 5	Mus musculus	92-97
11983278-4	2002	UDP-glucuronosyltransferase (UDP-GT) activities towards p-nitrophenol were markedly increased (51.8% or 1.5-fold) in rats that consumed tea compared with the control animals on water.	Water	177-182	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	29-35
12629252-1	2003	The authors describe seven patients with medically refractory temporal lobe epilepsy whose seizures were associated with peri-ictal water drinking behavior.	Water	132-137	perilipin 1	Homo sapiens	121-125
12629252-4	2003	Peri-ictal water drinking may represent a lateralizing sign indicating seizure onset in the nondominant temporal lobe.	Water	11-16	perilipin 1	Homo sapiens	0-4
30694266-8	2019	This proposed method was also successfully utilized for the determination of Hg2+ in drinking water, tap water and surface water with good recovery (&gt;91%) and high intra-day and inter-day precision.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
18968965-3	2003	The method was applied to the simultaneous determination of Na(I), Ca(II), Mg(II) and Zn(II) in drinking water with satisfactory results and a detection limit of 32 ng ml(-1) for Zn(II) was obtained.	Water	105-110	carbonic anhydrase 2	Homo sapiens	67-73
30694266-8	2019	This proposed method was also successfully utilized for the determination of Hg2+ in drinking water, tap water and surface water with good recovery (&gt;91%) and high intra-day and inter-day precision.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
12323127-3	2002	The induction of uroguanylin mRNA is elevated in intestinal zinc deficiency and nutriuretic peptides regulate epithelial transport of salt and water.	Water	143-148	guanylate cyclase activator 2B	Homo sapiens	17-28
30452791-2	2019	For the actinide dioxide cations, actinyl(V) AnO2 + , melding of experiment and computation provides insights into trends for hydrolysis, as well as for oxo-exchange between actinyls and water that proceeds by a hydrolysis pathway.	Water	187-192	anoctamin 2	Homo sapiens	45-49
12610210-8	2003	Because reaction coordinates from S to TS, both in water and in the enzyme, pass via NAC (i.e., S --&gt; NAC --&gt; TS), the reduction in the S --&gt; NAC barrier by 2.6 kcal/mol accounts for approximately 25% of the reduction of total barrier in the S --&gt; TS (10.7 kcal/mol).	Water	51-56	X-linked Kx blood group	Homo sapiens	85-88
12610210-8	2003	Because reaction coordinates from S to TS, both in water and in the enzyme, pass via NAC (i.e., S --&gt; NAC --&gt; TS), the reduction in the S --&gt; NAC barrier by 2.6 kcal/mol accounts for approximately 25% of the reduction of total barrier in the S --&gt; TS (10.7 kcal/mol).	Water	51-56	X-linked Kx blood group	Homo sapiens	105-108
12610210-8	2003	Because reaction coordinates from S to TS, both in water and in the enzyme, pass via NAC (i.e., S --&gt; NAC --&gt; TS), the reduction in the S --&gt; NAC barrier by 2.6 kcal/mol accounts for approximately 25% of the reduction of total barrier in the S --&gt; TS (10.7 kcal/mol).	Water	51-56	X-linked Kx blood group	Homo sapiens	105-108
12137754-3	2002	AQP1 did not show any significant change of water permeability when treated with CT. An adenylyl cyclase accelerator forskolin showed similar effects as CT did, suggesting that changes of the water permeability of AQP4 and AQP3 were due to an increase of intracellular cAMP concentration.	Water	192-197	aquaporin 4	Homo sapiens	214-218
30763576-5	2019	The function of glymphatic system is facilitated by aquaporin-4 (AQP-4), a water channel expressed in highly polarized manor in astrocytic endfeet, whose transcription is regulated by nuclear factor of activated T cells 5 (NFAT5).	Water	75-80	aquaporin 4	Homo sapiens	52-63
12138517-2	2002	The aim of this study is to investigate the efficacy of two different chemical disinfectant agents and tap water where the laryngoscope blades were contaminated by different microorganisms and try to create a simple, effective and easy decontamination method.	Water	107-112	nuclear RNA export factor 1	Homo sapiens	103-106
12623989-6	2003	The antidiuresis produced by Ang-(1-7) (40 pmol/100 g body weight) in water-loaded rats was also blocked by its analog [1 microg/100 g body weight; 3.08+/-0.8 vs 1.27+/-0.33 mL in Ang-(1-7)-treated rats].	Water	70-75	angiogenin	Rattus norvegicus	29-32
12623989-6	2003	The antidiuresis produced by Ang-(1-7) (40 pmol/100 g body weight) in water-loaded rats was also blocked by its analog [1 microg/100 g body weight; 3.08+/-0.8 vs 1.27+/-0.33 mL in Ang-(1-7)-treated rats].	Water	70-75	angiogenin	Rattus norvegicus	180-183
12442966-3	2002	Nevertheless, important variations in the vibrational spectra of the disodium 5"-guanosine monophosphate, 5"-GMP, have been observed in this work produced by submitting the commercial salt to the same general laboratory process that the obtained compounds, i.e., solving the commercial salt in water and subsequent recrystallization.	Water	294-299	5'-nucleotidase, cytosolic II	Homo sapiens	109-112
30763576-5	2019	The function of glymphatic system is facilitated by aquaporin-4 (AQP-4), a water channel expressed in highly polarized manor in astrocytic endfeet, whose transcription is regulated by nuclear factor of activated T cells 5 (NFAT5).	Water	75-80	aquaporin 4	Homo sapiens	65-70
30681859-2	2019	The DLG model was introduced to describe phospholipid Langmuir films at the air-water interface and can be mapped into a spin-1 model, with the single-site states s i = 0, +1, and -1 representing the three types of molecules in the system (w, o, and d), respectively.	Water	80-85	spindlin 1	Homo sapiens	121-127
12146880-4	2002	In Eskisehir (Turkey) drinking and tap water are supplied from a water treatment plant, consisting mainly of screening, sedimentation, filtration and sterilization units and having a capacity of 80.000 m3/d.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
12054510-4	2002	Among the redox-sensitive transcription factors, NF-kappaB and AP-1, we found that only AP-1 was activated by 200 microM H(2)O(2) in human lung cells.	Water	121-126	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-67
12624601-1	2003	We recently demonstrated that neuronal nitric oxide synthase (nNOS) messenger RNA (mRNA) is markedly increased in the kidneys of diabetic rats and water-deprived rats.	Water	147-152	nitric oxide synthase 1	Rattus norvegicus	30-60
30862702-3	2019	Here, we investigated the proposed water-mediated, hydrogen-bonded activation switch between the conserved NPxxY motif on transmembrane helix 7 (TMH7) and a conserved tyrosine in TMH5, which contributes to alpha1B-adrenoceptor (alpha1B-AR) and beta2-AR activation.	Water	35-40	adrenoceptor alpha 1B	Homo sapiens	206-226
12624601-1	2003	We recently demonstrated that neuronal nitric oxide synthase (nNOS) messenger RNA (mRNA) is markedly increased in the kidneys of diabetic rats and water-deprived rats.	Water	147-152	nitric oxide synthase 1	Rattus norvegicus	62-66
12054510-4	2002	Among the redox-sensitive transcription factors, NF-kappaB and AP-1, we found that only AP-1 was activated by 200 microM H(2)O(2) in human lung cells.	Water	121-126	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	88-92
11964255-5	2002	The bound conformation allows direct hydrogen bonds to form between the sugar and K182 of MBP, in addition to other water-mediated hydrogen bonds.	Water	116-121	myelin basic protein	Rattus norvegicus	90-93
12579275-1	2003	The present study was designed to investigate the protective effect of a dietary water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi or Mannentake) mycelia (designated as MAK) on the induction and development of azoxymethane (AOM)-induced colon tumors in male F344/Du Crj rats.	Water	81-86	male germ cell-associated kinase	Rattus norvegicus	192-195
30862702-3	2019	Here, we investigated the proposed water-mediated, hydrogen-bonded activation switch between the conserved NPxxY motif on transmembrane helix 7 (TMH7) and a conserved tyrosine in TMH5, which contributes to alpha1B-adrenoceptor (alpha1B-AR) and beta2-AR activation.	Water	35-40	adrenoceptor alpha 1B	Homo sapiens	228-238
31384776-8	2019	The applicability of the developed method was investigated by analyzing tap water, bottled mineral water and waste water and demonstrated satisfactory recoveries in the ranges of 86.4-120%.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
12593862-2	2003	In this study, the correlation between IRBP-specific Th1 cells in PBLs and the histological grading in the eyes was evaluated kinetically during EAU induction.	Water	145-148	negative elongation factor complex member C/D	Homo sapiens	53-56
12593862-3	2003	EAU was induced in B10.A mice with IRBP immunization and the eyes were enucleated for histological examination on days 0, 3, 7, 15, and 21 after immunization.	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	35-39
11978559-8	2002	The method of choice in treating palmoplantar hyperhidrosis is tap water iontophoresis.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
11978559-13	2002	It can be stated that in spite of the interesting and promising new alternatives, especially using botulinum toxin, the tried-and-true procedures such as tap water iontophoresis and aluminium chloride salts still have a firm place in the treatment of hyperhidrosis.	Water	158-163	nuclear RNA export factor 1	Homo sapiens	154-157
30663118-4	2019	Herein, core-shell nanoparticles based poly(lactic-co-glycolic) acid (PLGA) are fabricate, by encapsulating water-soluble catalase (Cat), an enzyme that can decompose H2 O2 to generate O2 , inside the inner core, and loading hydrophobic imiquimod (R837), a Toll-like-receptor-7 agonist, within the PLGA shell.	Water	108-113	toll-like receptor 7	Mus musculus	257-277
12195568-8	2002	The a* values for the cutaneous reaction caused by SLS dissolved in Leopoldine spa water ranged from 7.22 to 9.60 (mean 8.20) for 0.5% SLS and from 10.8 to 12.36 (mean 11.68) for the 1% SLS.	Water	83-88	surfactant protein A2	Homo sapiens	79-82
12195568-10	2002	Leopoldine spa water can, thus, be considered a natural therapeutic alternative for the treatment of inflammatory skin conditions.	Water	15-20	surfactant protein A2	Homo sapiens	11-14
12578959-0	2003	An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain.	Water	88-93	aquaporin 4	Mus musculus	38-42
12578959-10	2003	These studies identify a specific, syntrophin-dependent AQP4 pool that is expressed at distinct membrane domains and which mediates bidirectional transport of water across the brain-blood interface.	Water	159-164	aquaporin 4	Mus musculus	56-60
12505679-5	2003	We examined NK3r-immunoreactivity in several brain regions thought to be associated with the control of water and electrolyte balance including the bed nucleus of the stria terminalis, central nucleus of the amygdala, diagonal band of Broca, hippocampus, nucleus tractus solitarius, parabrachial nucleus, paraventricular nucleus of the hypothalamus, and supraoptic nucleus.	Water	104-109	tachykinin receptor 3	Rattus norvegicus	12-16
30500715-4	2019	For Cl2 and ClO2 treatments, the respective formation potential of THMs and HAAs from the three water sources studied exhibited unidentical trend suggesting that higher THM formation was not necessarily associated with higher HAA formation.	Water	96-101	endogenous retrovirus group W member 5	Homo sapiens	4-7
16256480-1	2003	Delamination and intercalation of a layered microporous aluminophosphate [Al3P4O16](3-) .3[CH3CH2NH3]+ (AlP) were carried out in water/ethanol/amine and water/methanol/amine solutions.	Water	129-134	ATHS	Homo sapiens	104-107
12073573-7	2002	The rate of bacteria elimination for hand-washing with soap and tap water after taking care of a patient was insufficient, especially when before care was provided the number of bacteria on the nurse"s hands were less than 100 CFU/agar plate.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
12181897-2	2002	By the oasis patches dynamic modeling, the vegetation-water interrelated analysis, and the estimation of water demand by the ecological system, the dynamic tendency of the Ejina oasis in the lower reach of Heihe River Basin under difference water resources allocating were studied.	Water	54-59	cAMP responsive element binding protein 3 like 1	Homo sapiens	178-183
12523861-2	2003	Galactosylated surfaces were then obtained by coupling a galactose derivative (1-O-(6"-aminohexyl)-D-galactopyranoside) to the AAc graft chains with the aid of a water-soluble carbodiimide (WSC) and N-hydroxysulfosuccinimide (sulfo-NHS).	Water	162-167	glycine-N-acyltransferase	Homo sapiens	127-130
12680094-2	2003	The present paper gives the results of assessment of the mutagenic activity of tap water.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
12708296-5	2003	The tap water filtration resistance of the dynamic bio-membrane sheet with gel-layer attaching on was about 1.9 x 10(9) m-1, which almost equaled to that of the untapped sheet.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
12708296-7	2003	The untapped dynamic bio-membrane sheet showed an initial resistance to tap water permeation, but the one with gel-layer attaching on had little initial resistance.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	6-9
12506083-12	2003	CONCLUSIONS: The positional dependence of relaxation times and the population indexes indicated that spin-spin relaxation represents the behavior of the bound water and the spin-lattice relaxation that of total water.	Water	159-164	spindlin 1	Homo sapiens	101-105
12506083-12	2003	CONCLUSIONS: The positional dependence of relaxation times and the population indexes indicated that spin-spin relaxation represents the behavior of the bound water and the spin-lattice relaxation that of total water.	Water	159-164	spindlin 1	Homo sapiens	106-110
12506083-12	2003	CONCLUSIONS: The positional dependence of relaxation times and the population indexes indicated that spin-spin relaxation represents the behavior of the bound water and the spin-lattice relaxation that of total water.	Water	159-164	spindlin 1	Homo sapiens	106-110
12506083-12	2003	CONCLUSIONS: The positional dependence of relaxation times and the population indexes indicated that spin-spin relaxation represents the behavior of the bound water and the spin-lattice relaxation that of total water.	Water	211-216	spindlin 1	Homo sapiens	101-105
12506083-12	2003	CONCLUSIONS: The positional dependence of relaxation times and the population indexes indicated that spin-spin relaxation represents the behavior of the bound water and the spin-lattice relaxation that of total water.	Water	211-216	spindlin 1	Homo sapiens	106-110
12506083-12	2003	CONCLUSIONS: The positional dependence of relaxation times and the population indexes indicated that spin-spin relaxation represents the behavior of the bound water and the spin-lattice relaxation that of total water.	Water	211-216	spindlin 1	Homo sapiens	106-110
12471606-5	2003	When a water molecule of the ligand binding site, observed in the antibody-TES crystal structure, was explicitly included in MM-PBSA calculations, the relative binding energies were 3.4, 4.9, and 5.4 kcal/mol for 5ADHT, AND, and DHEAS, respectively.	Water	7-12	sulfotransferase family 2A member 1	Homo sapiens	229-234
12521169-6	2002	Recoveries of the five sulfonylureas extracted from 1 L of tap water and surface water samples such as river water and rainwater at a 50 ng/L spike level were not lower than 96%.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
12450933-2	2002	We synthesized linear polyethylenimine-nitric oxide/nucleophile adduct (DS-1), a water-soluble nitric oxide donor, and demonstrated that it is a potent relaxant of precontracted rat aortic rings without inducing desensitization.	Water	81-86	mitochondrial ribosomal protein L58	Homo sapiens	72-76
12499649-13	2002	The intracellular PKC route activated by H(1) receptor activation enhances the permeability of water-soluble and poorly permeable drugs via opening of tight junctions in rat colonic membrane.	Water	95-100	protein kinase C, gamma	Rattus norvegicus	18-21
12602343-0	2002	Membrane water-penetration profiles from spin labels.	Water	9-14	spindlin 1	Homo sapiens	41-45
12602343-2	2002	With the Onsager approach to account for the variation in local dielectric constant, these results are used to determine the effective penetration profile of water into fluid phospholipid membranes, from recent electron paramagnetic resonance (EPR) studies on phospholipids spin-labelled systematically down the sn-2 chain.	Water	158-163	spindlin 1	Homo sapiens	274-278
12454260-9	2002	After the lid movement, PTL and colipase create a large hydrophobic plateau that can interact with the lipid-water interface.	Water	109-114	pancreatic lipase	Homo sapiens	24-27
12458414-7	2002	Unexpected oxidation of HgS in water or 1 M HCl was found for extractions performed in Teflon vials previously used for the digestion of residual undissolved HgS by aqua regia.	Water	31-36	hepatocyte growth factor-regulated tyrosine kinase substrate	Homo sapiens	24-27
12458414-7	2002	Unexpected oxidation of HgS in water or 1 M HCl was found for extractions performed in Teflon vials previously used for the digestion of residual undissolved HgS by aqua regia.	Water	31-36	hepatocyte growth factor-regulated tyrosine kinase substrate	Homo sapiens	158-161
12458414-8	2002	We presumed that the Teflon material could preserve some oxidising gases (presumably Cl(2)) developed during digestion with aqua regia which can then oxidise HgS during extraction with water or 1 M HCl.	Water	185-190	hepatocyte growth factor-regulated tyrosine kinase substrate	Homo sapiens	158-161
12383939-4	2002	In this study, we show that MT-III is able to protect against the DNA damage induced by ferric ion-nitrilotriacetic acid and H(2)O(2), and that this protective effect is inhibited by the alkylation of the sulfhydryl groups of MT-III by treatment with EDTA and N-ethylmaleimide.	Water	125-130	metallothionein 3	Homo sapiens	28-34
12226838-5	2002	The effect of IFN-gamma was still observed in the presence of H(2)O(2), which enhances the expression and activity of P-gp.	Water	62-67	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	118-122
12232046-10	2002	These results demonstrate that dystrophin is necessary for polarized distribution of AQP4 protein in brain where facilitated movements of water occur across the blood-brain barrier and cerebrospinal fluid-brain interface.	Water	138-143	aquaporin 4	Mus musculus	85-89
12204597-4	2002	Low-immunogenic water-soluble synthetic polymers sometimes exhibit significant immunomodulating activity, mainly concerning the activation/suppression of NK cells, LAK cells and macrophages.	Water	16-21	alpha kinase 1	Homo sapiens	164-167
12322735-11	2002	Tap water samples at Frankfurt/M (mean of 35 ng/L, maximum of 71 ng/L) were in the same range as MTBE amounts in drinking water at the Lower Rhine site.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
12352219-4	2002	One group (10 subjects) drank carbonated water and the other (11 subjects) tap water for almost 15 days.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
12216759-6	2002	RESULTS: The tap water produced misregistration of the needle images.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
12190313-8	2002	Further optimization led to compounds such as water soluble 45, which possesses a favorable pharmacokinetic profile in mice and demonstrates significant antitumor activity in vivo in several murine and human models, including an engineered murine mammary tumor that overexpresses cyclin E, the coactivator of CDK2.	Water	46-51	cyclin-dependent kinase 2	Mus musculus	309-313
12163681-10	2002	There were inverse correlations between the number of ACF and cecal butyrate concentration (r = -0.33, P &lt; 0.05) and between cecal water cytotoxicity and beta-glucuronidase activity (r = -0.70, P &lt; 0.001).	Water	134-139	glucuronidase, beta	Rattus norvegicus	157-175
12071833-0	2002	Saline Spa water and UV-B for psoriasis.	Water	11-16	surfactant protein A2	Homo sapiens	7-10
12141799-2	2002	Colitis was induced in Sprague-Dawley rats by 7 days of 4% DSS oral administration followed by 7 days of tap water for one, two, and three cycles.	Water	109-114	USO1 vesicle transport factor	Rattus norvegicus	105-108
12117645-2	2002	We evaluated urinary excretion of trichloroacetic acid (TCAA) as an exposure biomarker using 10 volunteers who normally consume their domestic tap water.	Water	147-152	nuclear RNA export factor 1	Homo sapiens	143-146
12120606-0	2002	In vitro effect of a spa water on the migratory and stimulatory capacities of human Langerhans calls.	Water	25-30	surfactant protein A2	Homo sapiens	21-24
12067712-5	2002	In addition, the GM00637/MT-III cells were highly protected from the H(2)O(2)-induced production of reactive oxygen species and DNA damage.	Water	69-74	metallothionein 3	Homo sapiens	25-31
12044166-3	2002	When a molecule (e.g., a natural protein known to bind to XIAP or a tetrapeptide mimic) displaces the dye, the emission shifts back to the spectrum observed in water.	Water	160-165	X-linked inhibitor of apoptosis	Homo sapiens	58-62
12044168-5	2002	To allow ion flux across the membrane Vpu would be required to assemble in homooligomers to form functional water-filled pores.	Water	108-113	Vpu	Human immunodeficiency virus 1	38-41
12044899-1	2002	Cytochrome c peroxidase (CcP) is a yeast mitochondrial enzyme that catalyzes the reduction of hydrogen peroxide to water by ferrocytochrome c. It was the first heme enzyme to have its crystallographic structure determined and, as a consequence, has played a pivotal role in developing ideas about structural control of heme protein reactivity.	Water	115-120	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	0-23
12044899-1	2002	Cytochrome c peroxidase (CcP) is a yeast mitochondrial enzyme that catalyzes the reduction of hydrogen peroxide to water by ferrocytochrome c. It was the first heme enzyme to have its crystallographic structure determined and, as a consequence, has played a pivotal role in developing ideas about structural control of heme protein reactivity.	Water	115-120	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	25-28
12215219-4	2002	Syk is required for p38 activation following stimulation with 10-100 microM H(2)O(2), but not with 1 mM H(2)O(2).	Water	76-81	spleen associated tyrosine kinase	Homo sapiens	0-3
12023920-4	2002	Descriptive epidemiology suggested that drinking unboiled tap water in a single water zone was the common factor linking cases.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
12023920-4	2002	Descriptive epidemiology suggested that drinking unboiled tap water in a single water zone was the common factor linking cases.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	58-61
12181897-2	2002	By the oasis patches dynamic modeling, the vegetation-water interrelated analysis, and the estimation of water demand by the ecological system, the dynamic tendency of the Ejina oasis in the lower reach of Heihe River Basin under difference water resources allocating were studied.	Water	105-110	cAMP responsive element binding protein 3 like 1	Homo sapiens	178-183
12181897-3	2002	The results showed that the lowest water demanded for preserving the present oasis area was about 5.7 x 10(8) m3 based on rational usage of the water resources.	Water	35-40	cAMP responsive element binding protein 3 like 1	Homo sapiens	77-82
12181897-3	2002	The results showed that the lowest water demanded for preserving the present oasis area was about 5.7 x 10(8) m3 based on rational usage of the water resources.	Water	144-149	cAMP responsive element binding protein 3 like 1	Homo sapiens	77-82
11943389-2	2002	The measurements were performed at two pH values of water: 2 and 6 and two temperatures 25 and 37 degrees C. It is shown that transport behavior of water into HPMC changes from being almost completely relaxation controlled (case II) at pH=2 to Fickian behavior for pH=6.	Water	148-153	polyhomeotic homolog 2	Homo sapiens	236-240
11917120-6	2002	Treatment of ZGs with the known water channel inhibitor Hg2+ is accompanied by a reversible loss in both the basal and GTP-stimulatable water entry and vesicle swelling.	Water	32-37	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	56-59
11904109-5	2002	Patients drank 480 mL of tap water at room temperature in less than 5 minutes.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
12033250-2	2002	Exposure of glucose oxidase to water-organic mixtures with a high (85-95%) content of the organic solvent resulted in stabilization of the enzyme by a membrane-forming polyelectrolyte.	Water	31-36	hydroxyacid oxidase 1	Homo sapiens	12-27
11913969-5	2002	The effect of small water-soluble, hydrophobic ligand 2,4-dinitrophenol (2,4-DNP) on TTR amyloid formation has been tested.	Water	20-25	transthyretin	Homo sapiens	85-88
11981647-3	2002	METHODS: EAU was induced in rats by immunization with interphotoreceptor retinoid-binding protein (IRBP) emulsified in complete Freund"s adjuvant.	Water	9-12	retinol binding protein 3	Rattus norvegicus	54-97
11981647-3	2002	METHODS: EAU was induced in rats by immunization with interphotoreceptor retinoid-binding protein (IRBP) emulsified in complete Freund"s adjuvant.	Water	9-12	retinol binding protein 3	Rattus norvegicus	99-103
11979327-5	2002	A penile water-cuff is connected through a pressure tube to a three-way tap.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	72-75
11979726-2	2002	The heterozygous mice for the tyrosine hydroxylase (TH) gene and for the cyclic AMP (cAMP) response element binding protein (CREB) binding protein (CBP) gene showed the impairment of latent learning in the water finding task, and these mice did not develop morphine dependence.	Water	206-211	CREB binding protein	Mus musculus	125-146
11979726-2	2002	The heterozygous mice for the tyrosine hydroxylase (TH) gene and for the cyclic AMP (cAMP) response element binding protein (CREB) binding protein (CBP) gene showed the impairment of latent learning in the water finding task, and these mice did not develop morphine dependence.	Water	206-211	CREB binding protein	Mus musculus	148-151
11884145-3	2002	The analysis reveals the enzyme-ligand interactions involved in inhibition of the mutase activity by vanadate and identifies a water molecule, observed in the native E.coli dPGM structure which, once activated by vanadate, may dephosphorylate the active protein.	Water	127-132	Phosphoglucose mutase 1	Drosophila melanogaster	173-177
11863462-1	2002	The maximal velocity of catalysis of CO(2) hydration by human carbonic anhydrase II (HCA II) requires proton transfer from zinc-bound water to solution assisted by His 64.	Water	134-139	carbonic anhydrase 2	Homo sapiens	62-83
11891259-0	2002	Benzothiadiazole-induced priming for potentiated responses to pathogen infection, wounding, and infiltration of water into leaves requires the NPR1/NIM1 gene in Arabidopsis.	Water	112-117	regulatory protein (NPR1)	Arabidopsis thaliana	143-147
11891259-0	2002	Benzothiadiazole-induced priming for potentiated responses to pathogen infection, wounding, and infiltration of water into leaves requires the NPR1/NIM1 gene in Arabidopsis.	Water	112-117	regulatory protein (NPR1)	Arabidopsis thaliana	148-152
12541976-6	2002	Tap water was analyzed under the same conditions.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
11902785-3	2002	The compounds released metal cations (Mg2+, Ca2 , Fe3+) and/or their hydroxides responding to various water environments due to their buffering pH function.	Water	102-107	carbonic anhydrase 2	Homo sapiens	44-47
11818406-1	2002	PURPOSE: Immunocytochemistry showed strong aquaporin (AQP)-4 water channel expression in Muller cells in mouse retina and fibrous astrocytes in optic nerve.	Water	61-66	aquaporin 4	Mus musculus	43-60
11858947-0	2002	Effect of tap-water iontophoresis on sweat gland recruitment, skin temperature and skin blood flow.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
11858947-2	2002	Seven days of tap-water iontophoresis decreased the number of active sweat glands by 72% which significantly increased forearm skin temperature and blood flow during mild exercise (70 W) in the heat (32 degrees C).	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
11812142-11	2002	Solvent inside apo-FABP, for example, shows characteristics of a water droplet, while solvent in holo-FABP benefits from interactions with the ligand headgroup and slightly stronger interactions with protein residues.	Water	65-70	fatty acid binding protein 2	Rattus norvegicus	19-23
11801238-1	2002	Plant mitochondria contain a non-protonmotive alternative oxidase (AOX) that couples the oxidation of ubiquinol to the complete reduction of oxygen to water.	Water	151-156	acyl-CoA oxidase 1	Homo sapiens	46-65
11801238-1	2002	Plant mitochondria contain a non-protonmotive alternative oxidase (AOX) that couples the oxidation of ubiquinol to the complete reduction of oxygen to water.	Water	151-156	acyl-CoA oxidase 1	Homo sapiens	67-70
11741725-2	2002	At least two aquaporin-type water channels are expressed in spinal cord: AQP1 in afferent sensory nerve fibers in the superficial layers of the dorsal horn, and AQP4 in glial cells throughout gray matter.	Water	28-33	aquaporin 4	Mus musculus	161-165
11786346-1	2002	This article describes a biosensor based on pH-sensitive field-effect transistors (pH-FETs) as transducer, and immobilised enzyme tyrosinase as biorecognition element, which was used for the determination of phenolic compounds in water solutions.	Water	230-235	tyrosinase	Homo sapiens	130-140
12519612-15	2002	For chronic wounds, the odds of developing an infection when cleansed with tap water compared with normal saline was 0.16, 95 % Confidence Interval (CI) 0.01, 2.96.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
12519612-20	2002	However the quality of the tap water should be considered prior to its use and in the absence of potable tap water, boiled and cooled water as well as distilled water can be used as wound cleansing agents.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
12968724-7	2002	Based on SAR, RSC and percent Na the surface water fall within the excellent to good quality class and subsurface water within good to permissible limit and it can be used for irrigation without any hazard.	Water	45-50	sarcosine dehydrogenase	Homo sapiens	9-12
12785105-5	2002	From both experimental and simulation approaches, elastin can be described as a two-phase model consisting of dynamic hydrophobic domains in water.	Water	141-146	elastin	Homo sapiens	50-57
12785105-6	2002	The hydrophobic domain of elastin is best described as a compact amorphous structure with distorted beta-strands, fluctuating turns, buried hydrophobic residues, and main-chain polar atoms that from hydrogen bonds with water.	Water	219-224	elastin	Homo sapiens	26-33
12785105-7	2002	Water plays a critical role in determining elastin"s conformational behavior, making elastin extremely dynamic in its relaxed state and providing an important source of elasticity.	Water	0-5	elastin	Homo sapiens	43-50
12785105-7	2002	Water plays a critical role in determining elastin"s conformational behavior, making elastin extremely dynamic in its relaxed state and providing an important source of elasticity.	Water	0-5	elastin	Homo sapiens	85-92
11793075-2	2002	The saline solution is usually made at home by adding measured quantities of common salt to tap water.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
11814617-4	2002	Infusion of Ang-(1-7) at the dose of 0.7 ng/kg.min produced a significant increase in jejunal water absorption compared to control (32% increase).	Water	94-99	angiogenin	Rattus norvegicus	12-20
11814617-5	2002	The Ang-(1-7) antagonist A-779 abolished the effect of Ang-(1-7) on water absorption.	Water	68-73	angiogenin	Rattus norvegicus	4-12
11814617-5	2002	The Ang-(1-7) antagonist A-779 abolished the effect of Ang-(1-7) on water absorption.	Water	68-73	angiogenin	Rattus norvegicus	55-63
11814617-7	2002	The increase in jejunal water absorption produced by Ang-(1-7) was blocked by the nitric oxide synthase inhibitor, L-NAME and by indomethacin.	Water	24-29	angiogenin	Rattus norvegicus	53-61
11814617-9	2002	Furthermore, the effect of Ang-(1-7) on jejunal water absorption is mediated by nitric oxide and by a cyclooxygenase-dependent mechanism.	Water	48-53	angiogenin	Rattus norvegicus	27-35
11773613-5	2002	AQP3 and AQP4 are both present in the basolateral plasma membrane of collecting duct principal cells and represent exit pathways for water reabsorbed apically via AQP2.	Water	133-138	aquaporin 4	Homo sapiens	9-13
11766801-2	2002	A total of 23 tap water samples were examined for infectious enteroviruses and adenoviruses by a cell culture technique followed by polymerase chain reaction (PCR) amplification.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
11766801-8	2002	Several types of adenovirus were detected in tap water samples and some water samples were found to contain adenoviruses which were closely related to enteric adenovirus types 40 and 41.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
11735393-5	2001	The kinetic isotope effect, k(bred)(H2O)/k(bred) (D2O) approximately 3, for reduction of cytochrome b in the low potential chain was approximately constant from pH 6-8.	Water	36-39	mitochondrially encoded cytochrome b	Homo sapiens	89-101
11771929-6	2001	Mean CdB was higher among children within 4 km of a zinc smelter and consuming &gt; or =500 ml of tap water daily (x1.34; 95% CI=[1.14-1.51]) compared with children living more than 4 km away and consuming &lt;500 ml of tap water daily.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
11713467-2	2001	Here we report evidence that attenuation of CA3 lesion-induced increases in circulating corticosterone levels with the synthesis inhibitor metyrapone, administered shortly before water-maze retention testing, blocks the impairing effects of the lesion on memory retrieval.	Water	179-184	carbonic anhydrase 3	Rattus norvegicus	44-47
11707570-1	2001	Although aquaporin 5 (AQP5) is the major water channel expressed in alveolar type I cells in the lung, its actual role in the lung is a matter of considerable speculation.	Water	41-46	aquaporin 5	Mus musculus	9-20
11707570-1	2001	Although aquaporin 5 (AQP5) is the major water channel expressed in alveolar type I cells in the lung, its actual role in the lung is a matter of considerable speculation.	Water	41-46	aquaporin 5	Mus musculus	22-26
11696353-1	2001	In an attempt to isolate protein kinase A anchoring proteins (AKAPs) involved in vasopressin-mediated water reabsorbtion, the complete sequence of the human AKAP Ht31 was determined and a partial cDNA of its rat orthologue (Rt31) was cloned.	Water	102-107	A-kinase anchoring protein 1	Homo sapiens	62-66
11722568-2	2001	A wealth of H(2)O-producing NADH oxidase (NOX) homologues have been discovered in the genomes of the hyperthermophilic Archaea, including two homologues in the genome of Pyrococcus furiosus which have been designated as NOX1 and NOX2.	Water	12-17	NADPH oxidase 1	Rattus norvegicus	220-224
11992093-5	2002	An artificial stone and tap water were sealed in a balloon.	Water	28-33	putative ABC-transporter	Sus scrofa	24-27
11992093-7	2002	While the kidney was affixed to and moved by a simulator, it was immersed in a specifically designed simulated animal model tank containing tap water.	Water	144-149	putative ABC-transporter	Sus scrofa	140-143
12111245-2	2002	In the Wistar rats, water deprivation caused an increase in the TPH activity in the anterior and middle (infundibular) parts of the hypothalamus, while hydration did not affect the activity of the enzyme in the anterior hypothalamus but produced an increase in its middle part.	Water	20-25	tryptophan hydroxylase 1	Rattus norvegicus	64-67
12111245-7	2002	The observations show that AVP is involved in the activation of TPH induced by water deprivation.	Water	79-84	tryptophan hydroxylase 1	Rattus norvegicus	64-67
11722568-5	2001	rNOX1 catalyzes the oxidation of NADH, producing both H(2)O(2) and H(2)O as reduction products of O(2) (O(2) + 1-2NADH + 1-2H(+) --&gt; 1-2NAD(+) + H(2)O(2) or 2H(2)O).	Water	54-59	NADPH oxidase 1	Rattus norvegicus	0-5
11722568-5	2001	rNOX1 catalyzes the oxidation of NADH, producing both H(2)O(2) and H(2)O as reduction products of O(2) (O(2) + 1-2NADH + 1-2H(+) --&gt; 1-2NAD(+) + H(2)O(2) or 2H(2)O).	Water	67-72	NADPH oxidase 1	Rattus norvegicus	0-5
30872305-5	2019	Approximately 75% of patients have antibodies against aquaporin-4, a water channel expressed on astrocytes.	Water	69-74	aquaporin 4	Homo sapiens	54-65
11605062-1	2001	The modifying effects of a dietary water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi or Mannentake) mycelia (MAK) on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were investigated in male F344 rats.	Water	35-40	male germ cell-associated kinase	Rattus norvegicus	132-135
12233788-1	2002	Aquaporin 4 (AQP4) is a recently discovered membrane bound water-selective channel and has been described at the light microscopic level to be predominantly expressed in the astrocytes of the brain, especially at the perivascular astrocyte endfoot processes.	Water	59-64	aquaporin 4	Mus musculus	0-11
30221789-1	2019	The composition of the ship"s ballast water is complex and contains a large number of microalgae cells, bacteria, microplastics, and other microparticles.	Water	38-43	inositol polyphosphate-5-phosphatase D	Homo sapiens	23-27
12233788-1	2002	Aquaporin 4 (AQP4) is a recently discovered membrane bound water-selective channel and has been described at the light microscopic level to be predominantly expressed in the astrocytes of the brain, especially at the perivascular astrocyte endfoot processes.	Water	59-64	aquaporin 4	Mus musculus	13-17
11570886-5	2001	The shape of the absorption spectrum of Co(2+)-DPP III was very similar to that of Co(2+)-carboxypeptidase A or Co(2+)-thermolysin, in which the Co(2+) is bound to two histidyl nitrogens, a water molecule, and a glutamate residue.	Water	190-195	dipeptidylpeptidase 3	Rattus norvegicus	47-54
30537651-0	2019	Impact of disinfectant on bacterial antibiotic resistance transfer between biofilm and tap water in a simulated distribution network.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
11680594-5	2001	By contrast, while CA I and II are prominent in normal colorectal mucosa, where they play a role in regulation of pH homeostasis and water and ion transport, loss of expression of these cytoplasmic isozymes consistently accompanies progression to malignant transformation.	Water	133-138	carbonic anhydrase 1	Homo sapiens	19-23
11909869-8	2002	A comparison of these with other PBGS structures identifies highly conserved active site water molecules, which are isolated from bulk solvent and implicated as proton acceptors in the PBGS-catalyzed reaction.	Water	89-94	aminolevulinate dehydratase	Homo sapiens	33-37
30537651-3	2019	The results revealed that the disinfectants (&gt;=2 mg/L) suppressed antibiotic resistant bacteria (ARB) in tap water and biofilms, while disinfected water and biofilms had a high relative abundance of ARB.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
30764891-0	2019	Head Tilt in Immunodeficient Mice Due to Contamination of Drinking Water by Burkholderia gladioli.	Water	67-72	NADPH oxidase 3	Mus musculus	0-9
12000273-0	2002	Application of tin and nanometer tin in allylation of carbonyl compounds in tap water.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
11681570-3	2001	The recoveries for the analytes in tap water varies between 70 and 100%.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
30132878-1	2019	Brain natriuretic peptide (BNP) is mainly produced in the ventricular myocardium, where it is released into the circulation, producing rapid volume decrease by diuresis, natriuresis, and water shift into the extracellular space, and vasodilation.	Water	187-192	natriuretic peptides B	Camelus dromedarius	0-25
11549275-4	2001	To obtain insights into mechanisms responsible for the effects of that polymorphism on enzymatic activity and thermal stability, we predicted the 3D structure of HNMT using the threading method and molecular dynamics simulations in water.	Water	232-237	histamine N-methyltransferase	Homo sapiens	162-166
11708070-0	2001	Simple miniaturized amperometric flow cell for monitoring residual chlorine in tap water.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
12057180-0	2002	[Halogenated by-products of chlorination in tap water].	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
12049398-4	2002	Results of chemical analysis showed that 2-methyl-isoborneol (2-MIB) was present in the source water.	Water	95-100	MIB E3 ubiquitin protein ligase 1	Homo sapiens	64-67
30132878-1	2019	Brain natriuretic peptide (BNP) is mainly produced in the ventricular myocardium, where it is released into the circulation, producing rapid volume decrease by diuresis, natriuresis, and water shift into the extracellular space, and vasodilation.	Water	187-192	natriuretic peptides B	Camelus dromedarius	27-30
30557661-2	2019	Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-beta (Abeta) clearance, possibly via the glymphatic system.	Water	19-24	aquaporin 4	Mus musculus	0-11
11931670-5	2002	Furthermore, pretreatment of Plcg1(+/+) cells with PKC-specific inhibitor decreased levels of PKC-dependent Bcl-2 phosphorylation, enhanced caspase-3 activity and their sensitivity to H(2)O(2).	Water	184-189	phospholipase C, gamma 1	Mus musculus	29-34
11584209-3	2001	METHODS: Fifteen colostomy irrigators(with more than 3 years" experience) performed washout with tap water compared with water containing 0.025 mg/kg glyceryl trinitrate.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
30557661-2	2019	Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-beta (Abeta) clearance, possibly via the glymphatic system.	Water	19-24	aquaporin 4	Mus musculus	13-17
11834210-4	2001	Subsequently, we demonstrate that fractions containing anthocyanins lower ROS (reactive oxygen species) and methemoglobin production in human erythrocytes treated with H(2)O(2.)	Water	168-173	hemoglobin subunit gamma 2	Homo sapiens	108-121
11933094-1	2002	Bombesin is a tetradecapeptide that possesses a random coil structure in pure water.	Water	78-83	gastrin releasing peptide	Homo sapiens	0-8
30557661-2	2019	Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-beta (Abeta) clearance, possibly via the glymphatic system.	Water	54-59	aquaporin 4	Mus musculus	0-11
11933094-4	2002	When an aqueous solution of bombesin is titrated with TFE, a continual decrease in the water/peptide interactions and a concomitant increase in the TFE/peptide interactions is observed, and at 30 % (v/v) TFE no homonuclear NOEs between water and the peptide can be detected.	Water	87-92	gastrin releasing peptide	Homo sapiens	28-36
11933094-4	2002	When an aqueous solution of bombesin is titrated with TFE, a continual decrease in the water/peptide interactions and a concomitant increase in the TFE/peptide interactions is observed, and at 30 % (v/v) TFE no homonuclear NOEs between water and the peptide can be detected.	Water	236-241	gastrin releasing peptide	Homo sapiens	28-36
30557661-2	2019	Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-beta (Abeta) clearance, possibly via the glymphatic system.	Water	54-59	aquaporin 4	Mus musculus	13-17
30557661-5	2019	We observed a 31% increase in exchange time in AQP4-deficient (Aqp4-/-) mice (452 +- 90 ms) compared to their wild-type counterparts (343 +- 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels.	Water	227-232	aquaporin 4	Mus musculus	63-67
12036059-6	2002	The results showed that dehydrogenation occurred randomly at the positions where hydroxyl groups are attached, but the most preferred position was C-3 and the radical position moved from C-3 to C-4 by the elimination of water molecule.	Water	220-225	complement C3	Homo sapiens	147-150
30557661-5	2019	We observed a 31% increase in exchange time in AQP4-deficient (Aqp4-/-) mice (452 +- 90 ms) compared to their wild-type counterparts (343 +- 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels.	Water	227-232	aquaporin 4	Mus musculus	47-51
12036059-6	2002	The results showed that dehydrogenation occurred randomly at the positions where hydroxyl groups are attached, but the most preferred position was C-3 and the radical position moved from C-3 to C-4 by the elimination of water molecule.	Water	220-225	complement C3	Homo sapiens	187-190
30557661-7	2019	This clinically relevant tool may be crucial to better understand the role of AQP4 in water transport across the BBI, as well as clearance of proteins in neurodegenerative conditions such as Alzheimer"s disease.	Water	86-91	aquaporin 4	Mus musculus	78-82
30401757-6	2019	At a CPAP level of 8 cm H2O, median ventilation efficiency index was significantly lower (1.27 [IQR, 1.04-1.91]) and median tau was not significantly different (11.2 [IQR, 8.3-18.9] s/cm H2O) compared with ventilation efficiency index and tau at CPAP of 6 cm H2O (P &lt; .001 and P = .12, respectively).	Water	24-27	centromere protein J	Homo sapiens	5-9
11914803-2	2002	The apparent diffusion coefficient (ADC) depends on the stage of cytotoxic edema and water content in the infarcted parenchyma.	Water	85-90	antizyme inhibitor 2	Rattus norvegicus	36-39
30401757-8	2019	CONCLUSIONS: Increasing the level of CPAP from 4 to 6 cm H2O was associated with enhanced ventilation efficiency and respiratory muscle function in convalescent premature infants on ventilation, but there was no further benefit from increasing the pressure &gt;6 cm H2O.	Water	57-60	centromere protein J	Homo sapiens	37-41
30401757-8	2019	CONCLUSIONS: Increasing the level of CPAP from 4 to 6 cm H2O was associated with enhanced ventilation efficiency and respiratory muscle function in convalescent premature infants on ventilation, but there was no further benefit from increasing the pressure &gt;6 cm H2O.	Water	266-269	centromere protein J	Homo sapiens	37-41
11897101-9	2002	Thus, decreased water intake by VGX rats was accompanied by decreased Fos-ir in the parvocellular PVN after the same treatments, indicating a role for the abdominal vagus in thirst in response to signaling from gut osmoreceptors.	Water	16-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	70-73
30609552-1	2019	An ultrasensitive and highly selective voltammetric sensor with ultra-trace level detection limit is introduced for RDX determination in water samples.	Water	137-142	radixin	Homo sapiens	116-119
30609552-11	2019	The utility of the sensor was checked for RDX analysis in water samples which led to satisfactory results.	Water	58-63	radixin	Homo sapiens	42-45
11953281-4	2002	METHODS: Altogether 66 volunteers were drinking 300 ml oxygenated or tap water within 15 minutes.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
30789878-3	2019	Untreated, unboiled city A tap water (i.e., well water) was the only exposure significantly associated with illness (odds ratio [OR] = 7.84; 95% confidence interval [CI] = 1.69-36.36).	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
11953281-8	2002	In the meantime they were drinking per day three times 300 ml either oxygenated water or tap water.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
30789878-3	2019	Untreated, unboiled city A tap water (i.e., well water) was the only exposure significantly associated with illness (odds ratio [OR] = 7.84; 95% confidence interval [CI] = 1.69-36.36).	Water	49-54	nuclear RNA export factor 1	Homo sapiens	27-30
11888902-6	2002	To simulate the situation in XPA patients, we used a hairless Xpa knockout mouse model and down-regulated the ODC activity by difluoromethylornithine (DFMO) administered in the drinking water.	Water	186-191	ornithine decarboxylase, structural 1	Mus musculus	110-113
30728297-4	2019	Using atomic-level simulations of diverse GPCRs, we show that most of the water molecules in GPCR crystal structures are highly mobile.	Water	74-79	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	42-46
11830654-4	2002	In earlier experiments, Ringer had suspended them in a saline medium for which he admitted to having used London tap water, which is hard: The hearts contracted beautifully.	Water	117-122	nuclear RNA export factor 1	Homo sapiens	113-116
11830654-5	2002	When he proceeded to replace the tap water with distilled water, he made a startling finding: The beating of the hearts became progressively weaker, and stopped altogether after about 20 min.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
11792666-3	2002	Expression of Fos (as assessed by immunohistochemistry) was increased in the organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus (MnPO), subfornical organ (SFO), and supraoptic nucleus (SON) after water deprivation.	Water	221-226	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
11792666-4	2002	After rehydration with water but before consumption of 1.8% NaCl, Fos expression in the SON disappeared and was partially reduced in the OVLT and MnPO.	Water	23-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-69
11792666-8	2002	The changes in Fos expression and PRA are consistent with a proposed role for ANG II in the control of the sodium appetite produced by water deprivation followed by rehydration with only water.	Water	135-140	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	15-18
11806948-4	2002	The spectral intensities in the aliphatic region undergo significant changes as 70% of the water in hydrated elastin is removed.	Water	91-96	elastin	Homo sapiens	109-116
11806948-7	2002	Our results support models in which water plays an integral role in the structure and proper function of elastin in vertebrate tissue.	Water	36-41	elastin	Homo sapiens	105-112
11887377-2	2002	The reactivity of the moisture-insensitive products with water was investigated by micro-multiple internal reflectance Fourier transform infrared spectroscopy (micro-MIR FTIR).	Water	57-62	membrane associated ring-CH-type finger 8	Homo sapiens	166-169
11908503-1	2002	Internal and rigid-body motions of bovine pancreatic trypsin inhibitor (BPTI) and of water molecules surrounding the BPTI are studied in a vicinity of an energy minimum using a normal mode analysis proposed as the independent molecule model.	Water	85-90	spleen trypsin inhibitor I	Bos taurus	117-121
11878189-7	2002	In pH 6.5 and 7.4 HPBCD solution, the degradation of CDS was mainly via acid catalyzed water addition reaction, thus, e.g. [Leu2]-TRH-CDS was more stable in pH 7.4 than in pH 6.5 aqueous solutions.	Water	87-92	thyrotropin releasing hormone	Mus musculus	130-133
11853885-1	2002	The expression, localization, and regulation of aquaporin 5 (AQP5), a member of the water channel family of proteins, was investigated in tissues of the rat gastrointestinal tract.	Water	84-89	aquaporin 5	Rattus norvegicus	48-59
11853885-1	2002	The expression, localization, and regulation of aquaporin 5 (AQP5), a member of the water channel family of proteins, was investigated in tissues of the rat gastrointestinal tract.	Water	84-89	aquaporin 5	Rattus norvegicus	61-65
11853885-6	2002	These results indicate that AQP5 is present in the rat lower stomach and duodenum where it may be involved in a water transport mechanism.	Water	112-117	aquaporin 5	Rattus norvegicus	28-32
11853885-7	2002	These results also support the idea that AQP5, and probably other aquaporins, are involved in water secretion in the stomach and duodenum although the volume of water transported via AQPs is unclear.	Water	94-99	aquaporin 5	Rattus norvegicus	41-45
11800603-2	2002	This intermediate has the same spectral and kinetic features as were found in prior studies of the oxidation of SCN(-) by H(2)O(2) or ClO(2).	Water	122-127	sorcin	Homo sapiens	112-115
12666839-2	2002	We have recently reported that a high concentration (50 g/L) of Mg sulfate fortification of drinking water attenuates atherogenesis in male and female LDL-receptor-deficient mice fed a high-cholesterol diet.	Water	101-106	low density lipoprotein receptor	Mus musculus	151-163
12666839-13	2002	An additional Mg salt (Mg-chloride) fortification of drinking water is capable of inhibiting atherogenesis in male LDL-receptor-deficient mice.	Water	62-67	low density lipoprotein receptor	Mus musculus	115-127
11899878-3	2002	Phenol and hydrochloric acid added to tap water caused statistically significant changes in anti-immunoglobulin activity of Klebsiella strains.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
12590200-6	2002	RESULTS: The outward-directed current was fully abolished by incubation with 1 mM ouabain and was significantly larger in oocytes expressing (S422D)SGK1, SGK1, SGK2 or SGK3, as compared to those injected with water.	Water	209-214	serum/glucocorticoid regulated kinase 1 L homeolog	Xenopus laevis	148-152
12391577-3	2002	The [H3O] loss proceeds via loss of water to form a pyran ion, which subsequently eliminates a hydrogen atom to form the stable pyrillium cation.	Water	36-41	H3 clustered histone 15	Homo sapiens	5-8
11742978-0	2001	Polarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexes.	Water	57-62	aquaporin 4	Canis lupus familiaris	52-56
11742978-1	2001	Aquaporin 4 (AQP4) is the predominant water channel in the brain.	Water	38-43	aquaporin 4	Canis lupus familiaris	0-11
11742978-1	2001	Aquaporin 4 (AQP4) is the predominant water channel in the brain.	Water	38-43	aquaporin 4	Canis lupus familiaris	13-17
11713283-5	2001	Mitochondria isolated from COQ7-deficient cells secreted more than 30 times as much H(2)O(2) at 42 as at 30 degrees C, while mitochondria isolated from cells simultaneously deficient in NDE1 and NDE2 secreted no H(2)O(2).	Water	84-90	putative monooxygenase CAT5	Saccharomyces cerevisiae S288C	27-31
11713283-5	2001	Mitochondria isolated from COQ7-deficient cells secreted more than 30 times as much H(2)O(2) at 42 as at 30 degrees C, while mitochondria isolated from cells simultaneously deficient in NDE1 and NDE2 secreted no H(2)O(2).	Water	84-89	putative monooxygenase CAT5	Saccharomyces cerevisiae S288C	27-31
11752387-11	2001	Germination and seedling establishment were compromised in the myb61 and ttg1-1 mutants under conditions of reduced water potential, suggesting a function for Arabidopsis seed mucilage during germination in dry conditions.	Water	116-121	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	73-79
11719447-4	2001	The daily administration of NAC with drinking water, initiated after the tumor mass had become established and detectable, produced a sharp inhibition of tumor growth, with regression of tumors in half of the treated mice along with a markedly prolonged median survival time.	Water	46-51	X-linked Kx blood group	Homo sapiens	28-31
11728429-2	2001	We now investigated whether the selective sigma(1) receptor agonist, 2-(4-morpholinoethyl)-1-phenylcyclohexane-1-carboxylate hydrochloride (PRE-084), could ameliorate spatial learning in aged animals, using a water-maze procedure.	Water	209-214	sigma non-opioid intracellular receptor 1	Rattus norvegicus	42-59
11695600-10	2001	The proportionate contributions of these factors to the evolution of water chemical composition were found to be 45%, 20%, and 10% for factors 1, 2 and 3, respectively.	Water	69-74	transcription termination factor 2	Homo sapiens	135-153
11679431-5	2001	Acute intravenous administration of GLP-1 also caused dose-dependent inhibition of water intake, and this effect was equally well abolished by previous administration of exendin(9-39).	Water	83-88	glucagon	Rattus norvegicus	36-41
11767887-0	2001	Development of an element-selective monitoring system for adsorbable organic halogens (AOX) with plasma emission spectrometric detection for quasi-continuous waste-water analysis.	Water	164-169	acyl-CoA oxidase 1	Homo sapiens	87-90
11767887-1	2001	An automated quasi-continuously-operating monitor has been developed for element-selective analysis of adsorbable organic halogens (AOX) in water.	Water	140-145	acyl-CoA oxidase 1	Homo sapiens	132-135
11720365-7	2001	The factors used to convert absorbed dose calibrations from graphite to water which are currently in use at the NPL were determined in previous work by Burns and Dale (1990 NPL Report RSA (EXT) 7) for all photon energies provided by the high-energy x-ray calibration service.	Water	72-77	N-acetylneuraminate pyruvate lyase	Homo sapiens	112-115
11720365-7	2001	The factors used to convert absorbed dose calibrations from graphite to water which are currently in use at the NPL were determined in previous work by Burns and Dale (1990 NPL Report RSA (EXT) 7) for all photon energies provided by the high-energy x-ray calibration service.	Water	72-77	N-acetylneuraminate pyruvate lyase	Homo sapiens	173-176
11710518-5	2001	In this study, we investigated the potential role of NO as an immunoregulator to alter Th1/Th2 cytokine production, as well as to inhibit the interphotoreceptor retinoid binding protein (IRBP)-induced EAU, a CD4+ Th1 cell-mediated autoimmune disease.	Water	201-204	retinol binding protein 3	Rattus norvegicus	142-185
11710518-5	2001	In this study, we investigated the potential role of NO as an immunoregulator to alter Th1/Th2 cytokine production, as well as to inhibit the interphotoreceptor retinoid binding protein (IRBP)-induced EAU, a CD4+ Th1 cell-mediated autoimmune disease.	Water	201-204	retinol binding protein 3	Rattus norvegicus	187-191
11603976-4	2001	Highly ordered domains (as determined from STM imaging) of the enantiomerically pure chiral redox polymers could be prepared via the interfacial reaction, over an HOPG substrate, of the bridging ligand in CH(2)Cl(2) and FeSO(4) in water.	Water	231-236	sulfotransferase family 1A member 3	Homo sapiens	43-46
11595212-8	2001	Thus, we have demonstrated that in senescent rats, hippocampal BDNF expression in response to water maze training is associated with memory performance.	Water	94-99	brain-derived neurotrophic factor	Rattus norvegicus	63-67
11573975-7	2001	We found a significant increase in protein abundance for NKCC2 and the beta- and gamma-subunits of ENaC with either water restriction or dDAVP infusion.	Water	116-121	solute carrier family 12 member 1	Rattus norvegicus	57-62
11587226-9	2001	In in vivo experiments, subcutaneous injection of 2 x 10(6) Ba/F3-SIN p210 cells in nude mice induced visible tumors in 2 weeks and all established tumors completely regressed upon addition of doxycycline in the drinking water (200 microg/ml).	Water	221-226	envoplakin	Mus musculus	70-74
11551599-2	2001	Contaminated tap water, used for rinsing surgical devices after disinfection, was identified as the source of the outbreak.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
11498256-3	2001	Biozzi ABH mice were found to be susceptible to EAU induction with native bovine IRBP.	Water	48-51	retinol binding protein 3	Bos taurus	81-85
29712003-2	2001	Boron enolates can be generated and used for aldol reactions in water by using a catalytic amount of Ph2 BOH.	Water	64-69	polyhomeotic homolog 2	Homo sapiens	101-104
11468383-1	2001	Crystals adopt the uncommon space group P4(2)/ncm and display a complex set of intermolecular interactions in which the water molecules play the crucial role: the water O-atom [O2(w)] accepts two hydrogen bonds and both water H atoms act as bifurcated donors.	Water	120-125	erythrocyte membrane protein band 4.2	Homo sapiens	40-45
11468383-1	2001	Crystals adopt the uncommon space group P4(2)/ncm and display a complex set of intermolecular interactions in which the water molecules play the crucial role: the water O-atom [O2(w)] accepts two hydrogen bonds and both water H atoms act as bifurcated donors.	Water	163-168	erythrocyte membrane protein band 4.2	Homo sapiens	40-45
11493096-0	2001	Saline spa water or combined water and UV-B for psoriasis vs conventional UV-B: lessons from the Salies de Bearn randomized study.	Water	11-16	surfactant protein A2	Homo sapiens	7-10
11493096-1	2001	OBJECTIVE: To study the effects of UV-B therapy and saline spa water given alone or in combination for the treatment of psoriasis.	Water	63-68	surfactant protein A2	Homo sapiens	59-62
11493096-10	2001	For group A, change in PASI was -29%, thus showing a minor therapeutic effect of saline spa water alone and poor efficacy compared with groups B and C (P&lt;.001).	Water	92-97	surfactant protein A2	Homo sapiens	88-91
11599176-3	2001	The rate constants are 1.8 x 10(-3) M-1 sec-1, 7.2 x 10(3) M-1 sec-1, and 1.5 x 10(6) sec-1 for acid, base and water catalysis, respectively.	Water	111-116	secretory blood group 1, pseudogene	Homo sapiens	40-45
11515530-10	2001	These results suggest that feeding oleic acid to rats exposed to water-immersion restraint further accelerated liver glycogen synthesis through the rise in liver SDH activity due to increased corticosterone secretion when compared with the effect from linoleic and alpha-linolenic acids.	Water	65-70	serine dehydratase	Rattus norvegicus	162-165
11464106-0	2001	Immunomodulation induced by Avene spring water on Th1- and Th2-dependent cytokine production in healthy subjects and atopic dermatitis patients.	Water	41-46	negative elongation factor complex member C/D	Homo sapiens	50-53
11394791-2	2001	Tap water, which had been filtered through biologically active granular activated carbon, was used as an innoculum for biofilm growth in annular reactors (ARs).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
11445506-4	2001	In addition, dipstick measurements were made of nitrates and nitrites in tap water for the subset of women living in the same home they had lived in during their pregnancies.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
11382807-1	2001	Several aquaporin-type water channels are expressed in mammalian airways and lung: AQP1 in microvascular endothelia, AQP3 in upper airway epithelia, AQP4 in upper and lower airway epithelia, and AQP5 in alveolar epithelia.	Water	23-28	aquaporin 4	Homo sapiens	149-153
11382807-7	2001	Osmotic water permeability in upper airways, measured by an in vivo instillation/sample method, was reduced by approximately 40% by AQP3/AQP4 deletion.	Water	8-13	aquaporin 4	Mus musculus	137-141
11376854-10	2001	During chronic osmotic stimulation by giving 2% NaCl solution for 2 and 5 days, a large number of Fos-positive neurons were observed, but the cessation of chronic osmotic stimulation by normal water drinking immediately decreased the number of Fos-positive neurons to the control level within 2 h. The number of FosB-positive neurons was increased with period of chronic osmotic stimulation, and a significant number were observed 2-8 h after the cessation of the stimulation.	Water	193-198	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	244-247
11292726-0	2001	Reversal of the CD4(+)/CD8(+) T-cell ratio in lymph node cells upon in vitro mitogenic stimulation by highly purified, water-soluble S3-S4 dimer of pertussis toxin.	Water	119-124	CD8a molecule	Homo sapiens	23-26
11477520-2	2001	Individual differences in consumption of bottled or filtered water, variability in tap water consumption at home and at work, dermal and inhalation exposure to volatile contaminants, and changes in residency during pregnancy may lead to exposure misclassification.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
11477520-6	2001	Pregnant women consumed more water than non-pregnant women (3.4 vs. 3.0 total l/day), especially cold tap water at home (1.8 vs. 1.3 l/day, 95% CI for the difference=0.1, 0.9).	Water	106-111	nuclear RNA export factor 1	Homo sapiens	102-105
11259297-3	2001	Langmuir monolayers of mixtures of Vpu and the phospholipid 1,2-dilignoceroyl-sn-glycero-3-phosphocholine (DLgPC) at the water-air interface were studied by synchrotron radiation-based x-ray reflectivity over a range of mole ratios at constant surface pressure and for several surface pressures at a maximal mole ratio of Vpu/DLgPC.	Water	121-126	Vpu	Human immunodeficiency virus 1	35-38
11455811-7	2001	Experiments using ISMs involve removing water from the ISM, amending it with the solutes of interest, re-injecting the amended water, and monitoring the solute concentrations with time.	Water	40-45	isthmin 1	Homo sapiens	18-21
11455811-7	2001	Experiments using ISMs involve removing water from the ISM, amending it with the solutes of interest, re-injecting the amended water, and monitoring the solute concentrations with time.	Water	127-132	isthmin 1	Homo sapiens	18-21
11305646-4	2001	When the short alkanethiol, 2,2"-diaminoethyldisulfide was preadsorbed onto gold, a monoexponential adsorption law was observed, and single GOx enzyme molecules could be seen on the surface where the enzyme was adsorbed from 50 nM GOx in water.	Water	238-243	hydroxyacid oxidase 1	Homo sapiens	140-143
11251046-6	2001	First, it acts as a molecular water pump: for each 2 Na+ and 1 sugar molecule 264 water molecules were cotransported in the human SGLT1 (hSGLT1), 424 for the rabbit SGLT1 (rSGLT1).	Water	30-35	solute carrier family 5 member 1	Rattus norvegicus	172-178
11266173-0	2001	The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2.	Water	32-37	phospholipase A2 group VII	Homo sapiens	59-98
11579665-3	2001	It also provides a primer on water treatment and alternatives to tap water.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
30728297-7	2019	Comparative analysis of GPCR crystal structures independently confirms the striking conservation of water-mediated interaction networks.	Water	100-105	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	24-28
30728297-8	2019	These conserved water-mediated interactions near the G protein-coupling region, along with diverse water-mediated interactions with extracellular ligands, have direct implications for structure-based drug design and GPCR engineering.	Water	16-21	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	216-220
30728297-8	2019	These conserved water-mediated interactions near the G protein-coupling region, along with diverse water-mediated interactions with extracellular ligands, have direct implications for structure-based drug design and GPCR engineering.	Water	99-104	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	216-220
12240354-1	2001	Uranium dioxide can be dissolved in supercritical CO2 with a CO2-philic TBP-HNO3 complexant to form a highly soluble UO2(NO3)(2).2TBP complex; this new method of dissolving UO2 that requires no water or organic solvent may have important applications for reprocessing of spent nuclear fuels and for treatment of nuclear wastes.	Water	194-199	TATA-box binding protein	Homo sapiens	72-75
12240354-1	2001	Uranium dioxide can be dissolved in supercritical CO2 with a CO2-philic TBP-HNO3 complexant to form a highly soluble UO2(NO3)(2).2TBP complex; this new method of dissolving UO2 that requires no water or organic solvent may have important applications for reprocessing of spent nuclear fuels and for treatment of nuclear wastes.	Water	194-199	TATA-box binding protein	Homo sapiens	130-133
11990623-5	2001	This method has been used to determine trace thiocyanate in urine and tap water samples.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
11990628-0	2001	On-line preconcentration system using a packed-bed filter for the determination of lead in tap water by inductively coupled plasma atomic emission spectrometry with ultrasonic nebulization.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
30342410-4	2019	Surface protection of a CdS-covered CZTS photocathode by a ZnS layer resulted in efficient photoelectrochemical water splitting with a maximum half-cell solar to hydrogen (HC-STH) efficiency of 2.1% and without showing appreciable degradation.	Water	112-117	saitohin	Homo sapiens	175-178
11231909-4	2001	JAK2 was activated rapidly in VSMCs treated with H(2)O(2), and signal transducers and activators of transcription (STAT) STAT1 and STAT3 were tyrosine-phosphorylated and translocated to the nucleus in a JAK2-dependent manner.	Water	49-54	Janus kinase 2	Rattus norvegicus	0-4
11231909-4	2001	JAK2 was activated rapidly in VSMCs treated with H(2)O(2), and signal transducers and activators of transcription (STAT) STAT1 and STAT3 were tyrosine-phosphorylated and translocated to the nucleus in a JAK2-dependent manner.	Water	49-54	Janus kinase 2	Rattus norvegicus	203-207
11564760-3	2001	Expression of AQP4 in transfected cells increased the osmotic water permeability coefficient (Pf) from 2.02 +/- 0.3 x 10-4 to 16.37 +/- 0.5 x 10-4 cm/s at 20 degrees C. Freeze-fracture EM showed distinct orthogonal arrays of particles (OAPs), the morphological signature of AQP4, on the plasma membrane of AQP4-expressing cells.	Water	62-67	aquaporin 4	Homo sapiens	14-18
30399481-5	2019	Ferric form of CYP2C19 was revealed to contain a six-coordinate low-spin heme with a water molecule as a sixth ligand in a distal site, and the addition of each drug caused varied minor fraction of five-coordinate heme.	Water	85-90	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	15-22
11564760-7	2001	Cell surface biotinylation experiments confirmed that AQP4 is internalized after 20 min of histamine exposure, which may account for the downregulation of water transport.	Water	155-160	aquaporin 4	Homo sapiens	54-58
11549581-12	2001	Oral consumption of alpha-difluoromethylornithine, an irreversible specific inhibitor of ODC, in the drinking water (1% w/v) to the transgenic mice resulted in complete prevention of UVB-mediated tumorigenesis and a substantial decrease in the formation of pigmented cysts (&lt;10 per mouse).	Water	110-115	ornithine decarboxylase, structural 1	Mus musculus	89-92
11288135-13	2001	Glucose supplementation restored P-450 2E1 expression but further suppressed rGSTA2 expression during water deprivation.	Water	102-107	glutathione S-transferase alpha 2	Rattus norvegicus	77-83
11708062-8	2001	The recoveries were 99 and 108% for tap water (4 ml loading) and underground water (12 ml loading), respectively.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
30399481-8	2019	Phenytoin and S-mephenytoin showed that binding to CYP2C19 occurred in a stepwise manner and that the coordination of a water molecule was facilitated in the second binding step.	Water	120-125	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	51-58
11318912-7	2001	For half of the tap water sources we examined, adults may fulfill between 8% and 16% of their Ca2+ DRI and between 6% and 31% of their Mg2+ DRI by drinking 2 liters per day.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
30769971-3	2019	In this work, we analyze previously published and new simulation results for three commonly used molecular water models (ST2, TIP4P/2005, and TIP5P) that support the existence of the metastable liquid-liquid transition.	Water	107-112	ST2	Homo sapiens	121-124
11327069-10	2001	RESULTS: The HPC counts, in colony forming units (CFU)/ml, were reduced 3- to 5-fold by flushing tap water through the units, but they returned after units were idle overnight.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
11371556-10	2001	In contrast to crude homogenate, the water-soluble C481 mutant was rapidly inactivated at 4 degrees C and 37 degrees C, which indicates that the membrane environment is required for the stability of MAO B.	Water	37-42	monoamine oxidase B	Homo sapiens	199-204
30792750-13	2019	We found significantly higher EGF, GRO, and RANTES levels in the water fraction compared to the lipid fraction of the lipid phase.	Water	65-70	C-C motif chemokine ligand 5	Homo sapiens	44-50
11421705-0	2001	Technetium(V) oxo complexes of substituted propylene diamine dioxime (PnAO) ligands: water-dependent interconversion between syn and anti isomers.	Water	85-90	synemin	Homo sapiens	125-128
11421705-9	2001	The syn and anti isomers interconverted in the presence of water; nonequilibrium mixtures of epimers remained unchanged under dry conditions.	Water	59-64	synemin	Homo sapiens	4-7
11421705-13	2001	The syn isomer was stabilized in water relative to the anti isomer.	Water	33-38	synemin	Homo sapiens	4-7
11288486-4	2001	The heterozygous mice for the tyrosine hydroxylase (TH) gene and for the cyclic AMP (cAMP) response element binding protein (CREB) binding protein (CBP) gene showed impairment of latent learning in the water finding task.	Water	202-207	CREB binding protein	Mus musculus	125-146
11288486-4	2001	The heterozygous mice for the tyrosine hydroxylase (TH) gene and for the cyclic AMP (cAMP) response element binding protein (CREB) binding protein (CBP) gene showed impairment of latent learning in the water finding task.	Water	202-207	CREB binding protein	Mus musculus	148-151
30628337-5	2019	However, it dramatically decreased to 10.1 kPa after washing with tap water on day 13, indicating that the cake layer was the main fouling mechanism.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
11261568-12	2001	These results indicate that kidney arginase was readily activated by Arg provided in the water, resulting in an immediate increase in plasma urea and ornithine.	Water	89-94	arginase 2	Homo sapiens	28-43
11287074-3	2001	In both groups, previous injections of the ANG II antagonist saralasin (Sar, 10(-10) M, 0.2 microl) into the SFO significantly attenuated the water intake caused by the ANG II injection, suggesting that the ANG II-induced drinking response may be mediated by the angiotensinergic LHA projections to the SFO.	Water	142-147	angiogenin	Rattus norvegicus	43-46
11287074-5	2001	The amount of water intake caused by either the injection of ANG II into the LHA or the SFO was significantly greater in the PG-treated than in the EB-treated animals.	Water	14-19	angiogenin	Rattus norvegicus	61-64
30628337-9	2019	The corresponding TMP only increased to 19.5 kPa after running for 12 d, which decreased to 5.6 kPa after washing with tap water on day 13.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
11454657-6	2001	The cyclic GMP-dependent protein kinase inhibitor KT5823 blocked the protective effects of ibudilast and dipyridamole on the H(2)O(2)-induced decrease in cell viability, while the cyclic AMP-dependent protein kinase inhibitor KT5720, the cyclic AMP antagonist Rp-cyclic AMPS, the mitogen-activated protein/extracellular signal-regulated kinase inhibitor PD98059 and the leukotriene D(4) antagonist LY 171883 did not.	Water	125-130	5'-nucleotidase, cytosolic II	Homo sapiens	11-14
11228965-2	2001	Long-term tests (6-8 months) in a synthetic, microbially stable soft tap water confirmed that lower pHs and higher temperatures increased copper release to water.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
30628337-12	2019	The TMP increased to 38.0 kPa on day 12, while it decreased to 3.8 kPa after washing with tap water on day 13.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
30628337-15	2019	After washing with tap water, the TMP decreased to 2.3 kPa on day 13, and the average pollutant removal efficiency was as high as 58.6%.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
11178956-1	2001	We have synthesized two water soluble dendritic porphyrins, termed DP1 and DP2 and have successfully radiolabeled them with 99mTc.	Water	24-29	receptor accessory protein 5	Rattus norvegicus	67-70
30694072-7	2019	The presence of water during anion exchange is found to have a deleterious effect on the Yb3+ PLQYs but does not affect the nanocrystal shapes or morphologies, or even reduce the excitonic PLQYs of analogous undoped CsPb(Cl1- xBr x)3 nanocrystals.	Water	16-21	RE1 silencing transcription factor	Homo sapiens	226-229
11463781-4	2001	A water transport channel in the kidney, AQP4, was downregulated in the mice, whereas other members of the gene family did not show differences in expression levels.	Water	2-7	aquaporin 4	Mus musculus	41-45
30717687-6	2019	Eyestrain, eye discharge, and dryness decreased with tap water (P = 0.020), Eye Shampoo (P = 0.036), and Eye Brush (P = 0.014), respectively.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
11431160-7	2001	In view of the fact that CFTR is highly expressed in pancreatic ductal cells where uroguanylin and its receptor are also localized, we assume that uroguanylin, an intrinsic pancreatic peptide, is involved in the regulation of electrolyte/water secretion in the ductal system via GC-C and CFTR.	Water	238-243	guanylate cyclase activator 2B	Homo sapiens	147-158
11161519-10	2001	By application of a PS with a methyl group at the end cap of the polyoxyethylene chain (PSM), the emulsion became most stable at a GES/PSM ratio of 1 : 2, and at the same time, the interfacial tension between the oil phase and the water phase became minimal.	Water	231-236	folate hydrolase 1B (pseudogene)	Homo sapiens	88-91
29929431-8	2019	HMGB1 inhibition improved motor function, reduced spinal cord water content, and attenuated spinal cord edema in SCI rats.	Water	62-67	high mobility group box 1	Rattus norvegicus	0-5
11100795-2	2001	A number of bacterial strains were isolated with high resistance against As3+ and As5+ ions which are able to degrade the water insoluble compounds triphenylarsine (TP) and triphenylarsineoxide (TPO).	Water	122-127	thyroid peroxidase	Mandrillus leucophaeus	195-198
11161657-6	2001	All lifetime cancer risks for CHCl(3), CHBrCl(2), CHBr2Cl, and CHBr3 from consuming tap water in the three water supply areas were higher than 10(-6).	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
11290736-0	2001	Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation.	Water	78-83	aquaporin 5	Mus musculus	27-38
11290736-5	2001	In contrast, the water permeability in parotid and sublingual acinar cells isolated from Aqp5(-)/- mice is decreased significantly.	Water	17-22	aquaporin 5	Mus musculus	89-93
11290736-6	2001	Water permeability decreased by 65% in parotid and 77% in sublingual acinar cells from Aqp5(-)/- mice in response to hypertonicity-induced cell shrinkage and hypotonicity-induced cell swelling.	Water	0-5	aquaporin 5	Mus musculus	87-91
30278216-0	2019	Ligand chirality can affect histidine protonation of vitamin-D receptor: ab initio molecular orbital calculations in water.	Water	117-122	vitamin D receptor	Homo sapiens	53-71
11290736-7	2001	These data show that AQP5 is the major pathway for regulating the water permeability in acinar cells, a critical property of the plasma membrane which determines the flow rate and ionic composition of secreted saliva.	Water	66-71	aquaporin 5	Mus musculus	21-25
11115728-4	2001	AQP4 is the predominant water channel in the brain and it is more widely distributed than originally believed, with a marked prevalence over periventricular areas.	Water	24-29	aquaporin 4	Homo sapiens	0-4
11414818-1	2001	Catalysis of (18)O exchange between CO(2) and water catalyzed by a Co(II)-substituted mutant of human carbonic anhydrase II is analyzed to show the rate of release of H(2)(18)O from the active site.	Water	46-51	carbonic anhydrase 2	Homo sapiens	102-123
30691235-0	2019	Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease.	Water	12-17	aquaporin 4	Homo sapiens	0-11
11403281-2	2001	In bulk solutions, the nonradiative decay rate constant of SRB increased with an increase in a solvent polarity parameter [ET(30)], and this relationship was used to estimate the polarities of water/oil interfaces.	Water	193-198	chaperonin containing TCP1 subunit 4	Homo sapiens	59-62
18968171-7	2001	The method was applied to the determination of periodate and iodate in tap water and spring water with satisfactory results.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
30691235-1	2019	Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain.	Water	24-29	aquaporin 4	Homo sapiens	0-11
30691235-1	2019	Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain.	Water	24-29	aquaporin 4	Homo sapiens	13-17
30589251-2	2019	We show that HNP membranes possess high water flux, have well-defined pore sizes, and rejection up to 80% of charged species in solution.	Water	40-45	kallikrein related peptidase 8	Homo sapiens	13-16
11206919-1	2001	Biofilm are formed wherever there is some water in our environment: pipes, pipelines, tap water systems, air conditioning systems...	Water	42-47	nuclear RNA export factor 1	Homo sapiens	86-89
11198025-3	2001	Over a period of 7 months, 5 (29%) of 17 patients were infected with P aeruginosa genotypes also detectable in tap water.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
11279049-1	2001	Aquaporin 5 (AQP5), the major water channel expressed in alveolar, tracheal, and upper bronchial epithelium, is significantly down-regulated during pulmonary inflammation and edema.	Water	30-35	aquaporin 5	Mus musculus	0-11
11279049-1	2001	Aquaporin 5 (AQP5), the major water channel expressed in alveolar, tracheal, and upper bronchial epithelium, is significantly down-regulated during pulmonary inflammation and edema.	Water	30-35	aquaporin 5	Mus musculus	13-17
30589251-7	2019	On the basis of their straightforward fabrication and tunable properties, HNP membranes may find applications in size- and charge-selective separations, water desalination, and responsive devices.	Water	153-158	kallikrein related peptidase 8	Homo sapiens	74-77
11441047-10	2001	This expression pattern suggests that X-dll3 is first involved in the patterning and genesis of all cells forming the olfactory tissue and is then involved in neurogenesis or neuronal maturation in putative water- and air-sensing epithelia.	Water	207-212	distal-less homeobox 5 L homeolog	Xenopus laevis	38-44
11441047-11	2001	In contrast, Pax-6 expression is restricted to the olfactory placode, larval PC and metamorphic MC, suggesting that Pax-6 is specifically involved in the formation of water-sensing epithelium.	Water	167-172	paired box 6 L homeolog	Xenopus laevis	13-18
11441047-11	2001	In contrast, Pax-6 expression is restricted to the olfactory placode, larval PC and metamorphic MC, suggesting that Pax-6 is specifically involved in the formation of water-sensing epithelium.	Water	167-172	paired box 6 L homeolog	Xenopus laevis	116-121
11548067-3	2001	In the current study, we specifically evaluated the long-term reproducibility of tap water and toenail concentrations of arsenic, and the relation between water, toenail, and urinary measurement.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
11548067-6	2001	Tap water arsenic concentrations ranged from undetectable (&lt;0.01 microg/L) to 66.6 microg/L.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
30624443-4	2019	In particular, a comparison of the band edge positions with the redox potential of water indicates that the heterostructures are potential photocatalysts for water splitting, enabling water reduction on the MX2 layer and water oxidation on the Mg(OH)2 layer.	Water	83-88	MX dynamin like GTPase 2	Homo sapiens	207-210
11474122-6	2001	The deamination of MBP with nitrous acid afforded phosphatidylinositols (PIs) and a water soluble, 97 kDa glycosylated protein.	Water	84-89	myelin basic protein	Rattus norvegicus	19-22
30624443-4	2019	In particular, a comparison of the band edge positions with the redox potential of water indicates that the heterostructures are potential photocatalysts for water splitting, enabling water reduction on the MX2 layer and water oxidation on the Mg(OH)2 layer.	Water	158-163	MX dynamin like GTPase 2	Homo sapiens	207-210
11341846-1	2001	gamma-Glutamyl transpeptidase (gammaGTase) catalyzes the transfer of the gamma-glutamyl moiety of gamma-glutamyl-derived peptides, such as glutathione (gammaGlu-Cys-Gly), and anilides, such as gamma-glutamyl-7-amido-4-methylcoumarin (gammaGlu-AMC), to acceptor molecules, including water and various dipeptides.	Water	282-287	inactive glutathione hydrolase 2	Homo sapiens	0-29
30624443-4	2019	In particular, a comparison of the band edge positions with the redox potential of water indicates that the heterostructures are potential photocatalysts for water splitting, enabling water reduction on the MX2 layer and water oxidation on the Mg(OH)2 layer.	Water	158-163	MX dynamin like GTPase 2	Homo sapiens	207-210
11341846-1	2001	gamma-Glutamyl transpeptidase (gammaGTase) catalyzes the transfer of the gamma-glutamyl moiety of gamma-glutamyl-derived peptides, such as glutathione (gammaGlu-Cys-Gly), and anilides, such as gamma-glutamyl-7-amido-4-methylcoumarin (gammaGlu-AMC), to acceptor molecules, including water and various dipeptides.	Water	282-287	inactive glutathione hydrolase 2	Homo sapiens	31-41
11239974-5	2001	Loads of SBTI and water significantly increased plasma CCK compared to sham loads, but loads of saline, glucose, and maltose did not.	Water	18-23	cholecystokinin	Rattus norvegicus	55-58
30624443-4	2019	In particular, a comparison of the band edge positions with the redox potential of water indicates that the heterostructures are potential photocatalysts for water splitting, enabling water reduction on the MX2 layer and water oxidation on the Mg(OH)2 layer.	Water	158-163	MX dynamin like GTPase 2	Homo sapiens	207-210
30624443-6	2019	In addition, all of the MX2/Mg(OH)2 heterostructures show strong optical absorption in the visible and infrared regions, indicating their promise for application in photocatalytic water splitting.	Water	180-185	MX dynamin like GTPase 2	Homo sapiens	24-27
30227379-0	2019	Integrated device based on cauliflower-like nickel hydroxide particles-coated fabrics with inverse wettability for highly efficient oil/hot alkaline water separation.	Water	149-154	alcohol dehydrogenase iron containing 1	Homo sapiens	136-139
11380187-4	2001	The rate and extent of RDX degradation in microcosms was enhanced by anaerobic bacteria that feed on cathodic hydrogen (i.e., H2 produced during anaerobic Fe(0) corrosion by water).	Water	174-179	radixin	Homo sapiens	23-26
11350169-5	2001	The factors that combine to produce favorable elements for TBP activity include overall flexibility; minor groove widening, as well as roll, rise, and shift increases at the ends of the TATA element; untwisting within the TATA element accompanied by large roll at the TATA element ends; and relatively low maximal water densities around the DNA.	Water	314-319	TATA-box binding protein	Homo sapiens	59-62
11394261-2	2001	The first DAF-systems used in the water industry were the ADKA and Sveen-Pedersen ones from the 1920s.	Water	34-39	CD55 molecule (Cromer blood group)	Homo sapiens	10-13
30227379-3	2019	After the superhydrophilic fabric is wetted by water in advance, hot alkaline water can be removed from the light oil/water mixture driven by gravity.	Water	47-52	alcohol dehydrogenase iron containing 1	Homo sapiens	65-68
30227379-3	2019	After the superhydrophilic fabric is wetted by water in advance, hot alkaline water can be removed from the light oil/water mixture driven by gravity.	Water	78-83	alcohol dehydrogenase iron containing 1	Homo sapiens	65-68
30540433-4	2019	In this study, we employed water-soluble carboxylic acid fullerenes (C60-COOH and C70-COOH) as the free radical scavenger and modify onto the surface of titanium dioxide by refluxed esterification (P25/C60-COOH or C70-COOH) technique.	Water	27-32	tubulin polymerization promoting protein	Homo sapiens	198-201
11085929-10	2000	Microinjection of mENT1, mENT1b or mENT2 cRNA into Xenopus oocytes resulted in enhanced uptake of [(3)H]uridine by the oocytes relative to that seen in water-injected controls.	Water	152-157	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	18-23
11294747-1	2001	Serotonin [5-hydroxytryptamine (5-HT)] and CCK injected into the lateral parabrachial nucleus (LPBN) inhibit NaCl and water intake.	Water	118-123	cholecystokinin	Rattus norvegicus	43-46
11316770-8	2001	We therefore examined the effect of water immersion-restraint stress on c-Fos protein accumulation in PrRP- and TH-immunoreactive neurons.	Water	36-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-77
30099315-3	2019	The MCM/CQDs prepared at the optimized condition showed different fluorescent properties (as indicated by the fluorescent emission wavelength and fluorescent response to acid) compared to the CQDs formed in water.	Water	207-212	methylmalonyl-CoA mutase	Homo sapiens	4-7
11820547-0	2001	Evidence-based practice: tap water cleansing of leg ulcers in the community.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
11149387-5	2000	Endogenous prolactin was shown to induce migration to water, courtship behavior, and cessation of spermatocytogenesis in the Cynops newt.	Water	54-59	prolactin	Gallus gallus	11-20
11112997-9	2000	In cTnI null mice made hypothyroid by addition of phenylthiouracil to the drinking water, ssTnI expression was prolonged and mice survived until day 20 or 21.	Water	83-88	troponin I, skeletal, slow 1	Mus musculus	90-95
11820547-3	2001	One question remains unanswered: What is the evidence for the use of sterile saline or clean tap water for cleansing of leg ulcers in the community?	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
30540309-20	2019	The present work taken with the one on aqueous [Fe(bpy)3]2+ enhances our understanding of the spin-state dependence of the structural and vibrational properties of Fe(ii) polypyridyl complexes in water, highlighting the strong interpenetration between their coordination sphere and their hydration shell.	Water	196-201	spindlin 1	Homo sapiens	94-98
11820547-5	2001	Application of these principles enabled clinicians to collaborate in the search for evidence to support or refute tap water cleansing of leg ulcers.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
11312289-2	2001	It has been demonstrated recently that astrocytes express high levels of a water channel, aquaporin-4 (AQP4).	Water	75-80	aquaporin 4	Homo sapiens	90-101
11110814-2	2000	The rats were trained to lick a protruding spout in response to one of several cue-tone stimuli (CTSs) to ingest water, or amino acid, NaCl or glucose solution.	Water	113-118	cathepsin S	Rattus norvegicus	97-101
31468417-8	2019	Then the heat stress group cells were cultivated in a 43  C thermostatic water bath for 6 h under heat stress, and then re-incubated under 37  C for 1 h. The results showed that compared with the control group, expression levels of Bax, Caspase-9, Caspase-3, Cyt-c, P53 and other pro-apoptosis factors in HS groups were significantly increased (P &lt; 0.05), while expression levels of anti-apoptosis factor Bcl-2 showed a significant decrease (P &lt; 0.05).	Water	73-78	BCL2-associated X protein	Mus musculus	232-235
11076501-4	2000	Next, water is eliminated between C5 and C6 of dTDP-4-ketoglucose to form dTDP-4-ketoglucose-5,6-ene.	Water	6-11	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	47-51
11076501-4	2000	Next, water is eliminated between C5 and C6 of dTDP-4-ketoglucose to form dTDP-4-ketoglucose-5,6-ene.	Water	6-11	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	74-78
11312289-2	2001	It has been demonstrated recently that astrocytes express high levels of a water channel, aquaporin-4 (AQP4).	Water	75-80	aquaporin 4	Homo sapiens	103-107
30066400-6	2019	Concomitant administration of netrin-1 with amyloid beta 1-42 (Abeta1-42 ) improved cognitive dysfunction in novel object recognition task (NOR), ameliorated impaired spatial memory in Morris water maze (MWM) setting, increased neuronal density and reduced amyloid aggregation in rat AD model.	Water	192-197	netrin 1	Rattus norvegicus	30-38
11320486-5	2001	AQP3 and AQP4 are both present in the basolateral plasma membrane of collecting duct principal cells and represent exit pathways for water reabsorbed apically via AQP2.	Water	133-138	aquaporin 4	Homo sapiens	9-13
18354587-0	2000	Reply to criticisms of the Pope and Fry paper on pure water absorption made in a comment by Quickenden et al.	Water	54-59	FRY microtubule binding protein	Homo sapiens	36-39
18354587-1	2000	The measurements of the absorption spectrum of pure water in a paper by Pope and Fry [Appl.	Water	52-57	FRY microtubule binding protein	Homo sapiens	81-84
30394213-0	2019	Exploring the Role of Water Molecules in the Ligand Binding Domain of PDE4B and PDE4D: Virtual Screening Based Molecular Docking of Some Active Scaffolds.	Water	22-27	phosphodiesterase 4D	Homo sapiens	80-85
11206712-0	2000	Calcium and bicarbonate ions mediate the inhibition of mast cell histamine release by Avene spa water.	Water	96-101	surfactant protein A2	Homo sapiens	92-95
11206712-1	2000	Avene spa water (ASW) inhibits the histamine release induced in mast cells by substance P; the inhibition is reversed by EDTA and by EGTA.	Water	10-15	surfactant protein A2	Homo sapiens	6-9
11231042-10	2001	While pretreatment with SAR dose-dependently reduced the water intake evoked by both 5-HT and ANGII, neither losartan nor PD 123,319 pretreatment affected the drinking induced by these treatments.	Water	57-62	sarcosine dehydrogenase	Homo sapiens	24-27
11290403-3	2001	In this work we use c-fos-like immunoreactivity to detect active areas involved in the long-term control of increased water and sodium intake due to partial aortic ligature.	Water	118-123	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	20-25
30394213-9	2019	RESULTS: In presence of water molecule, Roflumilast has more binding affinity (-8.48 Kcal/mol with PDE4B enzyme and -8.91 Kcal/mol with PDE4D enzyme) and forms two hydrogen bonds with Gln443 and Glu369 and amino acid with PDE4B and PDE4D enzymes respectively.	Water	24-29	phosphodiesterase 4D	Homo sapiens	136-141
11205061-12	2000	Our evidence for the basolateral localization of rAQP8 in acinar cells, coupled with previous findings that AQP5 is localized apically in the same cells, raises the possibility that water crosses the acinar epithelium through these channels during primary saliva formation.	Water	182-187	aquaporin 5	Rattus norvegicus	108-112
11311979-2	2001	AQP4 is speculated to maintain the homeostasis of intracellular and extracellular water in the brain, but little is known about the mechanism of induction of its expression.	Water	82-87	aquaporin 4	Homo sapiens	0-4
30394213-9	2019	RESULTS: In presence of water molecule, Roflumilast has more binding affinity (-8.48 Kcal/mol with PDE4B enzyme and -8.91 Kcal/mol with PDE4D enzyme) and forms two hydrogen bonds with Gln443 and Glu369 and amino acid with PDE4B and PDE4D enzymes respectively.	Water	24-29	phosphodiesterase 4D	Homo sapiens	232-237
30394213-10	2019	While in absence of water molecule its binding affinity has decreased (-7.3 Kcal/mol with PDE4B enzyme and -5.17 Kcal/mol with PDE4D enzyme) as well as no H-bond interactions were observed.	Water	20-25	phosphodiesterase 4D	Homo sapiens	127-132
31092756-7	2019	The unique distribution of AQP4 suggest that AQP4 might play a role in brain water homeostasis.	Water	77-82	aquaporin 4	Homo sapiens	27-31
11323770-2	2001	MR-spectroscopy (MRS) records protons from tissue chemicals other than water, intrinsic phosphorus containing metabolites, sodium, potassium, carbon, nitrogen, and fluorine.	Water	71-76	sterile alpha motif domain containing 11	Mus musculus	17-20
10867636-0	2000	Differential scanning calorimetry study of the hydrophobic hydration of the elastin-based polypentapeptide, poly(VPGVG), from deficiency to excess of water.	Water	150-155	elastin	Homo sapiens	76-83
31092756-7	2019	The unique distribution of AQP4 suggest that AQP4 might play a role in brain water homeostasis.	Water	77-82	aquaporin 4	Homo sapiens	45-49
10974639-4	2000	The health center does have electricity and tap water.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
11348060-4	2001	The North Rim water is some 8 per mil more depleted in deltaD than most of the water issuing from springs on the South Rim except for that from Indian Garden Spring which lies below the Clearwell Overflow wash.	Water	14-19	regulating synaptic membrane exocytosis 1	Homo sapiens	10-13
30507194-5	2018	The growth of water clusters changes the peak heights of the radial distribution functions in PF6 and NTf2 systems.	Water	14-19	nuclear transport factor 2	Homo sapiens	102-106
11348060-6	2001	The difference in stable isotopic composition of the North Rim water renders it not only traceable in Indian Garden Spring water, but the proportions may be determined as well which result in projecting an admixture of up to half the total discharge.	Water	63-68	regulating synaptic membrane exocytosis 1	Homo sapiens	59-62
11349981-6	2001	Although these findings suggest the serological response may be associated with type of tap water and certain foods, additional research is needed to clarifythe role of both food and drinking water in endemic Cryptosporidium infection.	Water	92-97	nuclear RNA export factor 1	Homo sapiens	88-91
11324723-0	2001	Guanylin family: new intestinal peptides regulating electrolyte and water homeostasis.	Water	68-73	guanylate cyclase activator 2A	Rattus norvegicus	0-8
11089677-4	2000	Plants with the frs1 mutation recovered their wild-type phenotype, their capability to tolerate freezing temperatures and their capability to retain water after an exogenous abscisic acid (ABA) treatment.	Water	149-154	FAR1-related sequence 1	Arabidopsis thaliana	16-20
30444126-3	2018	The acidity of nitroalkane in [BMPY][NTf2] covers ~8 p K units and is significantly weaker than those in DMSO and water.	Water	114-119	nuclear transport factor 2	Homo sapiens	37-41
10986349-0	2000	Differential Fos expression in the paraventricular nucleus of the hypothalamus, sacral parasympathetic nucleus and colonic motor response to water avoidance stress in Fischer and Lewis rats.	Water	141-146	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-16
10986349-3	2000	Exposure for 60 min to water avoidance stress increased the number of Fos positive cells in the paraventricular nucleus of the hypothalamus (PVN), nucleus tractus solitarius (NTS), and the parasympathetic nucleus of the lumbo-sacral spinal cord (L6-S1) in both Lewis and Fischer rats compared with non stress groups.	Water	23-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	70-73
11307974-8	2001	The procedure is applicable to the quantification of bisphenol A in tap water, raw water and stream water.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
11254383-7	2001	This open channel is filled by the inhibitor P(1)" group which adopts a constrained conformation to fit this pocket, together with two water molecules interacting with the ST3-specific residue Gln215.	Water	135-140	matrix metallopeptidase 11	Homo sapiens	172-175
11026155-6	2000	The survey allowed Merlin to redirect resources earmarked for a clean water programme towards health education and improving primary health-care services.	Water	70-75	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	19-25
30561329-2	2018	Influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquaporin-4 (AQP4).	Water	112-117	aquaporin 4	Mus musculus	126-137
11220594-6	2000	The analytical results obtained for standard reference materials are in good agreement with the certified or indicated values and satisfactory recoveries of spiked cobalt in tap water are obtained.	Water	178-183	nuclear RNA export factor 1	Homo sapiens	174-177
30561329-2	2018	Influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquaporin-4 (AQP4).	Water	112-117	aquaporin 4	Mus musculus	139-143
30560905-0	2018	Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells.	Water	134-139	aquaporin 4	Homo sapiens	165-176
11103297-13	2000	Tap water was a more important source of fluoride than soft drinks.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
11263895-3	2001	The ribosyl triazolotriazine 16, which was synthesized as a result of these calculations, exists predominantly as the covalent hydrate 18 in water and is a potent inhibitor of mammalian ADA (IC(50) 50 nM).	Water	141-146	adenosine deaminase	Homo sapiens	186-189
30300780-4	2018	With the application of excitation emission matrix-parallel factor analysis (EEM-PARAFAC), we found that I-THM formation in UV-chloraminated water correlated well with two ratios of three PARAFAC humic-like components (C3/C2 and C1/C2, R2 = 0.958-1.000), suggesting that the ratios of fluorescent components can be used as reliable indicators for I-THM formation.	Water	141-146	complement C3	Homo sapiens	219-234
11456923-1	2001	Molecular dynamics (MD) simulations and free energy component analysis have been performed to evaluate the molecular origins of the 5.5 kcal/mol destabilization of the complex formed between the N-terminal RNP domain of U1A and stem loop 2 of U1 snRNA upon mutation of a conserved aromatic residue, Phe56, to Ala. MD simulations, including counterions and water, have been carried out on the wild type and Phe56Ala peptide-stem loop 2 RNA complexes, the free wild type and Phe56Ala peptides, and the free stem loop 2 RNA.	Water	356-361	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	220-223
10849430-1	2000	Aquaporin-5 (AQP5) is a water channel protein that is selectively expressed in respiratory, salivary, and lacrimal tissues.	Water	24-29	aquaporin 5	Rattus norvegicus	0-11
10849430-1	2000	Aquaporin-5 (AQP5) is a water channel protein that is selectively expressed in respiratory, salivary, and lacrimal tissues.	Water	24-29	aquaporin 5	Rattus norvegicus	13-17
30252476-6	2018	In both complexes, we observe significant changes in the water local density as the two proteins approach, supporting the existence of a clear dewetting transition in the case of MDM2-p53, with an onset distance of 5.6-7.6 A.	Water	57-62	MDM2 proto-oncogene	Homo sapiens	179-183
10925260-9	2000	Upon stimulation with dendritic cells in the presence of the water-soluble DNFB analogue, DNBS, CTLA-4+ T cells from DNFB-tolerized mice secreted high levels of IL-10, TGF-beta, and IFN-gamma; low levels of IL-2; and no IL-4, resembling the cytokine pattern of T regulatory 1 cells.	Water	61-66	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	96-102
11299077-1	2001	The present study investigated the digestion and cholesterol-lowering effects of the water-soluble NSP guar gum (GG) and sodium alginate (SA) in laboratory animals.	Water	85-90	reticulon 1	Rattus norvegicus	99-102
30645217-0	2018	Modeling the ship white water wake in the midwave infrared.	Water	24-29	inositol polyphosphate-5-phosphatase D	Homo sapiens	13-17
11386160-5	2001	Apparently 5-HT1B and 5-HT2A receptors play an activating role in regulation of water intake, whereas 5-HT1A, 5-HT2C and 5-HT3 receptors act as inhibitory ones.	Water	80-85	5-hydroxytryptamine receptor 1B	Rattus norvegicus	11-17
11349296-2	2001	Compounds highly polarizable or sharing substituents that facilitate charge delocalization adsorbed faster by reduced (SWa-R) than by unaltered (SWa-U) clay, indicating stronger dipole--dipole interactions between the substituents and the clay surface and/or hydrating water molecules.	Water	269-274	intersectin 2	Homo sapiens	119-122
11349296-2	2001	Compounds highly polarizable or sharing substituents that facilitate charge delocalization adsorbed faster by reduced (SWa-R) than by unaltered (SWa-U) clay, indicating stronger dipole--dipole interactions between the substituents and the clay surface and/or hydrating water molecules.	Water	269-274	intersectin 2	Homo sapiens	145-148
10924349-2	2000	We demonstrate that in vitro the Na(+)/K(+)-ATPase, a non heme-protein, is able to disproportionate H(2)O(2) catalatically into dioxygen and water, as well as C(40) catalase.	Water	141-146	immunoglobulin kappa variable 1D-39	Homo sapiens	104-108
30630284-3	2018	In this study, we isolated an Acanthamoeba CJW/W1 strain from tap water in Wuxi, Jiangsu Province, China.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
12524742-0	2000	Fluoride levels best in tap water, study finds.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
11171953-4	2001	A typical complex, Co(L(22))(2)(2+) is shown to engage in rapid exchange with a competing ligand L(11) and with another complex, Co(L(22))(2)(2+) in 30% acetonitrile/water at pH 7.0 and 25 degrees C. The exchange in the corresponding Co(III) complexes is shown to be much slower.	Water	166-171	immunoglobulin kappa variable 1-6	Homo sapiens	97-102
30630284-8	2018	This is the first report of an Acanthamoeba strain isolated from tap water in Wuxi, China.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
10930316-2	2000	We have previously shown that IFN-gamma-deficient mice (GKO) on the C57BL/6 background are equally susceptible to interphotoreceptor retinoid binding protein (IRBP)-induced EAU as the wild type (WT).	Water	173-176	retinol binding protein 3, interstitial	Mus musculus	114-157
10930316-2	2000	We have previously shown that IFN-gamma-deficient mice (GKO) on the C57BL/6 background are equally susceptible to interphotoreceptor retinoid binding protein (IRBP)-induced EAU as the wild type (WT).	Water	173-176	retinol binding protein 3, interstitial	Mus musculus	159-163
30171873-7	2018	From GDs 14-20, ethanol-containing tap water at concentrations of 30% and 15% (v/v) was administered to the high- and low-ethanol groups, respectively.	Water	39-44	SEC14-like lipid binding 2	Rattus norvegicus	35-38
10952131-3	2000	Based on enthalpy and volume differences between the conformers, these bands are assigned to the syn conformer which has hydrogen bonds between the fluorine atom and water molecules (syn" conformer).	Water	166-171	synemin	Homo sapiens	97-100
10952131-3	2000	Based on enthalpy and volume differences between the conformers, these bands are assigned to the syn conformer which has hydrogen bonds between the fluorine atom and water molecules (syn" conformer).	Water	166-171	synemin	Homo sapiens	183-186
10952131-4	2000	The number of H2O molecules binding to the syn" conformer is estimated to be 2.4 from the concentration dependence of the spectrum.	Water	14-17	synemin	Homo sapiens	43-46
11250198-8	2001	Interaction with the degenerate position is mediated by a purine-specific hydrogen bond to N7, ensuring specificity, and water-mediated H bonding to the purine N6/O6 and pyrimidine N4/O4, allowing degeneracy.	Water	121-126	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	160-165
30171873-8	2018	Tap water without ethanol was given to the control group.	Water	4-9	SEC14-like lipid binding 2	Rattus norvegicus	0-3
30599635-4	2018	In the case of measuring water droplets, the measurable size range of the extended IPI enlarges to 10 mum-1 mm, with high-quality fringe patterns favoring the accuracy of measurement.	Water	25-30	PWWP domain containing 3A, DNA repair factor	Homo sapiens	102-107
11152614-6	2001	Water was critical to the inverse temperature transition and elastin-associated water molecules can be divided into three categories: those closely associated with beta II turns; those that form hydrogen bonds with the main-chain groups; and those hydrating the hydrophobic side-chains.	Water	0-5	elastin	Homo sapiens	61-68
11152614-6	2001	Water was critical to the inverse temperature transition and elastin-associated water molecules can be divided into three categories: those closely associated with beta II turns; those that form hydrogen bonds with the main-chain groups; and those hydrating the hydrophobic side-chains.	Water	80-85	elastin	Homo sapiens	61-68
11152614-7	2001	Water-swollen, monomeric elastin above the transition temperature is best described as a compact amorphous structure with distorted beta-strands, fluctuating turns, buried hydrophobic residues, and main-chain polar atoms that participate in hydrogen bonds with water.	Water	0-5	elastin	Homo sapiens	25-32
11152614-7	2001	Water-swollen, monomeric elastin above the transition temperature is best described as a compact amorphous structure with distorted beta-strands, fluctuating turns, buried hydrophobic residues, and main-chain polar atoms that participate in hydrogen bonds with water.	Water	261-266	elastin	Homo sapiens	25-32
10879874-2	2000	In order to provide reproducible samples with moderate presence of possible interferences, spiked tap water was used for this first set of experiments.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
10940724-10	2000	The result suggests that AQP7 may function as a pathway for transcellular water transport in PST in concert with more widely expressed AQP1 in proximal tubules.	Water	74-79	aquaporin 7	Rattus norvegicus	25-29
30189517-3	2018	Using a US pregnancy cohort, we assessed the impact of receiving well water arsenic test results on subsequent use of arsenic-contaminated tap water.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	139-142
30189517-3	2018	Using a US pregnancy cohort, we assessed the impact of receiving well water arsenic test results on subsequent use of arsenic-contaminated tap water.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
11217022-6	2001	The method was successfully applied to a local tap water sample and an aqueous soil extract.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
30189517-5	2018	Upon enrollment participants provided a tap water sample which was tested for arsenic using ICP-MS. During pregnancy and every four months after, participants were asked their extent of tap water use for drinking, cooking and mixing infant formula.	Water	190-195	nuclear RNA export factor 1	Homo sapiens	186-189
10816604-3	2000	Using Southern blot PCR and Western blot analysis, we demonstrate that primary astrocyte cultures from mouse express the AQP4 water channel at both the RNA and protein levels.	Water	126-131	aquaporin 4	Mus musculus	121-125
10816604-9	2000	Using Western blot and PCR experiments, we exclude the presence of AQP7 in astrocytes, indicating that only AQP4 is responsible for the rapid water movement.	Water	142-147	aquaporin 4	Mus musculus	108-112
30189517-6	2018	Logistic regression was used to estimate the odds of tap water use at one year post-partum in relation to baseline tap water use and arsenic concentration.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
30189517-6	2018	Logistic regression was used to estimate the odds of tap water use at one year post-partum in relation to baseline tap water use and arsenic concentration.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	115-118
30189517-6	2018	Logistic regression was used to estimate the odds of tap water use at one year post-partum in relation to baseline tap water use and arsenic concentration.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	53-56
11840863-0	2001	[Evaluation of effectiveness of water-salt supplement in the long-duration "MIR" missions].	Water	32-37	membrane associated ring-CH-type finger 8	Homo sapiens	76-79
30189517-6	2018	Logistic regression was used to estimate the odds of tap water use at one year post-partum in relation to baseline tap water use and arsenic concentration.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
10882406-2	2000	Here we show, for the MHC molecule HLA-A2, that this ability may be facilitated by a flexible water network that forms an interface between the MHC molecule and the peptide.	Water	94-99	major histocompatibility complex, class I, C	Homo sapiens	22-25
10882406-2	2000	Here we show, for the MHC molecule HLA-A2, that this ability may be facilitated by a flexible water network that forms an interface between the MHC molecule and the peptide.	Water	94-99	major histocompatibility complex, class I, C	Homo sapiens	144-147
30189517-7	2018	Compared to those who used tap water &lt;50% of the time, mothers who reported using tap water for drinking and cooking &gt;50% of time in their prenatal questionnaire had 8.54 times the odds of using their tap water at 1-year postpartum (95% CI: 5.37, 13.60).	Water	31-36	nuclear RNA export factor 1	Homo sapiens	85-88
10882406-6	2000	Conversely, for complexes of HLA-A2 with the more hydrophobic peptides, the water molecules are more rigidly bound at the MHC-peptide interface and a number of well-defined water-binding sites exist.	Water	76-81	major histocompatibility complex, class I, C	Homo sapiens	122-125
30189517-7	2018	Compared to those who used tap water &lt;50% of the time, mothers who reported using tap water for drinking and cooking &gt;50% of time in their prenatal questionnaire had 8.54 times the odds of using their tap water at 1-year postpartum (95% CI: 5.37, 13.60).	Water	31-36	nuclear RNA export factor 1	Homo sapiens	85-88
11124219-9	2001	The taste threshold in tap water was 2.6 mg/l Cu for both copper sulfate and copper chloride.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
30189517-7	2018	Compared to those who used tap water &lt;50% of the time, mothers who reported using tap water for drinking and cooking &gt;50% of time in their prenatal questionnaire had 8.54 times the odds of using their tap water at 1-year postpartum (95% CI: 5.37, 13.60).	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
12395502-7	2001	Significant positive correlation was found in SAR (0.53) and RSC (0.47) of irrigation water with pH of soil.	Water	86-91	sarcosine dehydrogenase	Homo sapiens	46-49
11822818-12	2001	The interacted HGF would be released from gelatin hydrogels only when they were degraded to generate water-soluble gelatin fragments.	Water	101-106	hepatocyte growth factor	Mus musculus	15-18
17216984-5	2001	The reassessment proved that, there was an increase in number of families use tap water inside the house by 29% compared with 1995 assessment.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
11771547-3	2001	Average fluence of the HLP (HLP10) with LET infinity H2O greater than 10 keV micrometers-1 was evaluated as 1.3 x 10(4) n cm-2 for the 9.8-day low-Earth-orbit mission (400 km x 51.65 degrees).	Water	53-56	HLP	Homo sapiens	23-26
11771547-3	2001	Average fluence of the HLP (HLP10) with LET infinity H2O greater than 10 keV micrometers-1 was evaluated as 1.3 x 10(4) n cm-2 for the 9.8-day low-Earth-orbit mission (400 km x 51.65 degrees).	Water	53-56	HLP	Homo sapiens	28-33
11382138-4	2001	It is proposed to examine the basic principles of water radiolysis as far as they pertain to generation of H2/D2 and O2 and try to apply these concepts to reactors both under operating conditions and in accident situations.	Water	50-55	relaxin 2	Homo sapiens	107-119
11113627-8	2000	In RHEC, high glucose (22 mM) and H(2)O(2) (100 microM) were able to increase the mRNA encoding ecNOS, but not iNOS.	Water	34-39	nitric oxide synthase 3	Rattus norvegicus	96-101
11215012-7	2000	The most commonly consumed water intake categories were plain and boiled tap water.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	73-76
11113078-9	2000	CONCLUSIONS: These results demonstrate that CRF acts peripherally to stimulate colonic motility and that CRF-R1 is primarily involved in mediating IP CRF/urocortin- and water avoidance stress-induced colonic motor response.	Water	169-174	corticotropin releasing hormone receptor 1	Rattus norvegicus	105-111
11101553-10	2000	CONCLUSIONS: This investigation shows that LD can be transmitted from a whirlpool spa used for display only, and highlights the need for minimizing the risk of transmission of LD from all water-filled spas.	Water	188-193	surfactant protein A2	Homo sapiens	82-85
11180637-2	2000	In the presence of water, HN-1 (bis(2-choroethyl)ethylamine), HN-2 and HN-3 undergo hydrolysis to form N-ethyldiethanolamine, N-methyldiethanolamine and triethanolamine (TEA), respectively; these compounds can be readily detected as adsorbed species on soil particles.	Water	19-24	MT-RNR2 like 3 (pseudogene)	Homo sapiens	71-75
11075778-1	2000	Urine output in astronauts following ingestion of an oral water load was low in space on the Russian space station Mir and less than during simulation by 6 degrees head-down bed rest.	Water	58-63	membrane associated ring-CH-type finger 8	Homo sapiens	115-118
11102009-0	2000	Air-water interface-induced smectic bilayer We show, using surface pressure versus molecular area isotherms measurements and x-ray reflectivity, that the long diblock semifluorinated n-hexaeicosane molecules, F(CF2)(8)-(CH2)18H, form a stable smectic bilayer phase, noted M1, with a total thickness of 3.	Water	4-9	ATPase H+ transporting accessory protein 1	Homo sapiens	209-214
10998050-6	2000	In a similar way to human carbonic anhydrase II, the buffer behaves formally as a second substrate in a ping-pong pattern, suggesting that proton transfer between a zinc-bound water molecule and buffer limits the maximal rate of catalysis in both systems at low buffer concentrations.	Water	176-181	carbonic anhydrase 2	Homo sapiens	26-47
11040190-7	2000	RESULTS: Cholera toxin-induced water and electrolyte secretion was inhibited by the substance P antagonists and the NK-1 and NK-2 receptor antagonists, but not by the NK-3 receptor antagonist or by pretreatment with capsaicin.	Water	31-36	tachykinin receptor 2	Rattus norvegicus	125-138
11110211-9	2000	The results are therefore consistent with their relative concentration in tap water and their vapor pressures.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
11028268-11	2000	Tap water from municipal nets has not to be considered as relevant source of sporadic infections.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
10990371-5	2000	In contrast, mice lacking AQP4, a water channel expressed mainly in the inner medullary collecting duct, manifest only a mild defect in maximum urinary concentrating ability.	Water	34-39	aquaporin 4	Mus musculus	26-30
10995272-1	2000	Bovine beta-lactoglobulin-carboxymethyl cyclodextrin (beta-LG-CMCyD) conjugate was prepared using water-soluble carbodiimide, in an effort to improve the functional properties of the protein.	Water	98-103	beta-lactoglobulin	Bos taurus	7-25
10995272-1	2000	Bovine beta-lactoglobulin-carboxymethyl cyclodextrin (beta-LG-CMCyD) conjugate was prepared using water-soluble carbodiimide, in an effort to improve the functional properties of the protein.	Water	98-103	beta-lactoglobulin	Bos taurus	54-61
11077330-1	2000	Water-coupled Na&amp;sup+ absorption in the colon is mediated principally by Na+/H+ exchange (isoforms NHE2 and NHE3).	Water	0-5	solute carrier family 9 member A2	Rattus norvegicus	103-107
10946299-5	2000	An LPS-LBP binding competition assay revealed an interaction of the treponeme phenol/water extracts with LBP, while precipitation studies implied an affinity to polymyxin B and endotoxin neutralizing protein.	Water	85-90	lipopolysaccharide binding protein	Homo sapiens	7-10
10946299-5	2000	An LPS-LBP binding competition assay revealed an interaction of the treponeme phenol/water extracts with LBP, while precipitation studies implied an affinity to polymyxin B and endotoxin neutralizing protein.	Water	85-90	lipopolysaccharide binding protein	Homo sapiens	105-108
10982423-0	2000	A maize vacuolar invertase, IVR2, is induced by water stress.	Water	48-53	invertase 2	Zea mays	28-32
11234440-10	2000	The results of this study--seen in the trend in some parameters monitored both before and after the cycle of crenotherapy using Merano Spa water--clearly show that that the crenotherapy studied had an effect on aspecific chronic phlogosis of the upper respiratory tract.	Water	139-144	surfactant protein A2	Homo sapiens	135-138
10915655-1	2000	The aquaporin-4 (AQP4) water channel has been proposed to play a role in gastric acid secretion.	Water	23-28	aquaporin 4	Mus musculus	4-15
10915655-1	2000	The aquaporin-4 (AQP4) water channel has been proposed to play a role in gastric acid secretion.	Water	23-28	aquaporin 4	Mus musculus	17-21
10915657-0	2000	Colon water transport in transgenic mice lacking aquaporin-4 water channels.	Water	6-11	aquaporin 4	Mus musculus	49-60
10915657-1	2000	Transgenic null mice were used to test the hypothesis that water channel aquaporin-4 (AQP4) is involved in colon water transport and fecal dehydration.	Water	59-64	aquaporin 4	Mus musculus	73-84
10915657-1	2000	Transgenic null mice were used to test the hypothesis that water channel aquaporin-4 (AQP4) is involved in colon water transport and fecal dehydration.	Water	59-64	aquaporin 4	Mus musculus	86-90
10915657-12	2000	These results provide evidence that transcellular water transport through AQP4 water channels in colonic epithelium facilitates transepithelial osmotic water permeability but has little or no effect on colonic fluid secretion or fecal dehydration.	Water	50-55	aquaporin 4	Mus musculus	74-78
10915657-12	2000	These results provide evidence that transcellular water transport through AQP4 water channels in colonic epithelium facilitates transepithelial osmotic water permeability but has little or no effect on colonic fluid secretion or fecal dehydration.	Water	79-84	aquaporin 4	Mus musculus	74-78
10975575-0	2000	Water-protein interactions in the molten-globule state of carbonic anhydrase b: an NMR spin-diffusion study.	Water	0-5	carbonic anhydrase 2	Homo sapiens	58-78
11710108-2	2000	Using analogies from nature, we investigated the possibility that tyrosinase-catalyzed reactions of 3,4-dihydroxyphenethylamine (dopamine) could confer water-resistant adhesive properties to semidilute solutions of the polysaccharide chitosan.	Water	152-157	tyrosinase	Homo sapiens	66-76
11109210-9	2000	Black non-Hispanic children also drank more tap water (21.3 ml/kg/day) than white non-Hispanic children (12.7 ml/kg/day) and Hispanic children (14.9 ml/kg/day).	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
10945210-4	2000	By immunolocalization with an antibody targeted to the N-terminus of the aquaporin, the localization of NtAQP1-protein at sites of expected high water transport rates from and to the apoplast or symplast could be demonstrated.	Water	145-150	probable aquaporin TIP1-1	Nicotiana tabacum	104-110
10945210-5	2000	The specific pattern of NtAQP1 distribution in petioles strongly indicates a transcellular movement of water.	Water	103-108	probable aquaporin TIP1-1	Nicotiana tabacum	24-30
10828498-1	2000	Atrial natriuretic factor (ANF) and C-type natriuretic peptide (CNP) receptors have been described in encephalic areas and nuclei related to the regulation of cardiovascular as well as sodium and water homeostasis.	Water	196-201	natriuretic peptide A	Rattus norvegicus	0-25
10828498-1	2000	Atrial natriuretic factor (ANF) and C-type natriuretic peptide (CNP) receptors have been described in encephalic areas and nuclei related to the regulation of cardiovascular as well as sodium and water homeostasis.	Water	196-201	natriuretic peptide A	Rattus norvegicus	27-30
10828498-1	2000	Atrial natriuretic factor (ANF) and C-type natriuretic peptide (CNP) receptors have been described in encephalic areas and nuclei related to the regulation of cardiovascular as well as sodium and water homeostasis.	Water	196-201	natriuretic peptide C	Rattus norvegicus	36-62
10828498-1	2000	Atrial natriuretic factor (ANF) and C-type natriuretic peptide (CNP) receptors have been described in encephalic areas and nuclei related to the regulation of cardiovascular as well as sodium and water homeostasis.	Water	196-201	natriuretic peptide C	Rattus norvegicus	64-67
10865315-16	2000	When an alternative disinfection technique is required, washing the speculum with chlorhexidine gluconate and tap water is preferred over wiping with a 70% isopropyl alcohol swab.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	110-113
10866986-7	2000	In a separate experiment using rats, delivery of carbonated water to the tongue significantly increased the number of cells expressing c-fos-like immunoreactivity in the dorsomedial trigeminal nucleus caudalis (versus saline controls); this was significantly reduced by pretreatment with acetazolamide.	Water	60-65	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	135-140
10888497-1	2000	Bovine beta-lactoglobulin (beta-LG) was conjugated to each of three cationic saccharides [glucosamine (GlcN), chitopentaose (CPO), and chitosan (CHS)] by means of a water-soluble carbodiimide or by the Maillard reaction in an effort to improve the functional properties of beta-LG.	Water	165-170	beta-lactoglobulin	Bos taurus	7-25
10888497-1	2000	Bovine beta-lactoglobulin (beta-LG) was conjugated to each of three cationic saccharides [glucosamine (GlcN), chitopentaose (CPO), and chitosan (CHS)] by means of a water-soluble carbodiimide or by the Maillard reaction in an effort to improve the functional properties of beta-LG.	Water	165-170	beta-lactoglobulin	Bos taurus	27-34
10806347-13	2000	These results suggest that AZF1, AZF2, AZF3, and STZ are all involved in the water-stress response in an ABA-dependent or -independent pathway to regulate downstream genes.	Water	77-82	zinc-finger protein 1	Arabidopsis thaliana	27-31
10775127-1	2000	Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are cardiac hormones that are involved in water and electrolyte homeostasis in heart failure.	Water	111-116	natriuretic peptide A	Rattus norvegicus	0-26
10775127-1	2000	Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are cardiac hormones that are involved in water and electrolyte homeostasis in heart failure.	Water	111-116	natriuretic peptide A	Rattus norvegicus	28-31
10842904-0	2000	Colonic cleansing, fluid absorption, and discomfort following tap water and soapsuds enemas.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
10816008-14	2000	Subsequently, using molecular dynamic in water, we have found the free PP1c subunits to be less stable than the complexed ones and we have speculated on possible reasons for this feature.	Water	41-46	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	71-75
10792624-1	2000	BACKGROUND: Enhanced expression of the kidney-specific sodium transporter, rBSC1, in the thick ascending limb of Henle (TAL) and of the renal water channel, aquaporin-2 (AQP2), in collecting duct has been identified in rats with congestive heart failure (CHF) as a cause for enhanced sodium and water retention in this condition.	Water	142-147	solute carrier family 12 member 1	Rattus norvegicus	75-80
10792624-1	2000	BACKGROUND: Enhanced expression of the kidney-specific sodium transporter, rBSC1, in the thick ascending limb of Henle (TAL) and of the renal water channel, aquaporin-2 (AQP2), in collecting duct has been identified in rats with congestive heart failure (CHF) as a cause for enhanced sodium and water retention in this condition.	Water	295-300	solute carrier family 12 member 1	Rattus norvegicus	75-80
10800035-3	2000	To date, perfusion information has invariably been obtained by subtraction of images with and without spin-labeling of inflowing water.	Water	129-134	spindlin 1	Homo sapiens	102-106
10832370-0	2000	Bottled vs. tap water--how about fluoride and iodine?	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
10757993-5	2000	TMX-1 appeared to be soluble in water up to a concentration of at least 1 mg/mL (0.3 mM).	Water	32-37	thioredoxin related transmembrane protein 1	Homo sapiens	0-5
10784175-6	2000	The number of feeding spaces did not affect the productivity of the pigs, but the presence of water within the feeder resulted in increases in ADFI (P &lt; .05) and ADG (P &lt; .05) and a reduction in carcass lean (P &lt; .05).	Water	94-99	ADG	Sus scrofa	165-168
10784175-17	2000	The inclusion of water within a feeder decreases time spent eating, but it increases ADFI and ADG.	Water	17-22	ADG	Sus scrofa	94-97
10798697-4	2000	Thermal simulations were repeated using blood perfusion values ranging from 0.5 to 5 kg/m3 s. Results demonstrate the ability of DCC array applicators to effectively and uniformly heat tissue down to a depth of 7.5-10 mm below the skin surface for a large number of different combinations of DCC element size, spacing, and water bolus thickness.	Water	323-328	DCC netrin 1 receptor	Homo sapiens	129-132
10756169-0	2000	Workplace-related complaints due to exposure to contaminated humidifier water and the VDI guideline 6022 We describe a case report of one patient with hypersensitivity pneumonitis (humidifier lung) due to exposure to contaminated humidifier water and another four patients with related complaints.	Water	241-246	VDI	Homo sapiens	86-89
10722758-1	2000	Aquaporin-5 (AQP5) is a water channel protein expressed in lung, salivary gland, and lacrimal gland epithelia.	Water	24-29	aquaporin 5	Mus musculus	13-17
10696074-6	2000	Using semiquantitative Northern blots, we observed that messenger RNA (mRNA) for aquaporin-5, the type I cell-specific water channel, was markedly decreased.	Water	119-124	aquaporin 5	Mus musculus	81-92
10760703-5	2000	Since the urinary Tamm-Horsfall protein has a high gel-forming tendency, it has been postulated that it takes part in the water impermeability of TAL.	Water	122-127	transaldolase 1	Homo sapiens	146-149
10744346-2	2000	The present study set out to explore the importance of angiotensin (Ang)II in the brain in allowing the somatosensory system to cause a reflex renal nerve-mediated reduction in renal sodium and water excretion.	Water	194-199	angiogenin	Rattus norvegicus	68-71
10795927-5	2000	Deletion of AQP5, the apical membrane water channel in the salivary gland, caused defective saliva production.	Water	38-43	aquaporin 5	Mus musculus	12-16
10752611-1	2000	A single water molecule (w135), buried within the structure of rat intestinal fatty acid binding protein (I-FABP), is investigated by NMR, molecular dynamics simulations, and analysis of known crystal structures.	Water	9-14	fatty acid binding protein 2	Rattus norvegicus	67-104
10752611-1	2000	A single water molecule (w135), buried within the structure of rat intestinal fatty acid binding protein (I-FABP), is investigated by NMR, molecular dynamics simulations, and analysis of known crystal structures.	Water	9-14	fatty acid binding protein 2	Rattus norvegicus	106-112
10752611-8	2000	Computer simulations suggest that escape of w135 from the I-FABP matrix is primarily determined by conformational fluctuations of the protein backbone and interactions with external water molecules.	Water	182-187	fatty acid binding protein 2	Rattus norvegicus	58-64
10675525-1	2000	This study compares the properties of the extrinsic 33 kDa subunit acting as "manganese stabilizing protein" (MSP) of the water oxidizing complex with characteristic features of proteins that are known to attain a "natively unfolded" or a "molten globule" structure.	Water	122-127	microseminoprotein beta	Homo sapiens	110-113
10800246-2	2000	BACKGROUND: Based on sporadic reports of microbial contamination of mineral waters, it has been recommended that, for safety reasons, particularly immunocompromised patients should drink tap water rather than bottled mineral water.	Water	191-196	nuclear RNA export factor 1	Homo sapiens	187-190
10800246-11	2000	CONCLUSION: Tap water as well as bottled water are both supremely safe components of nutrition.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
10800246-12	2000	The recommendation that tap water is better than mineral water, particularly for high-risk patients, is not supported by the literature.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
10764744-11	2000	These results suggest that catalase, overexpressed in the cytosolic or especially the mitochondrial compartment, potentiates TNF-alpha-induced apoptosis and activation of caspases by removal of H(2)O(2).	Water	194-199	catalase	Cricetulus griseus	27-35
10827973-5	2000	Preliminary analysis of the interactions of the Kir6.2 channel model with K(+) ions and water molecules during these simulations suggests that concerted single-file motion of K(+) ions and water through the selectivity filter occurs.	Water	88-93	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	48-54
10827973-5	2000	Preliminary analysis of the interactions of the Kir6.2 channel model with K(+) ions and water molecules during these simulations suggests that concerted single-file motion of K(+) ions and water through the selectivity filter occurs.	Water	189-194	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	48-54
10916342-8	2000	Among the visitors to Ogose who were traced, 7 persons who stayed only one day during the outbreak and drank half a glass to 2 glasses (100 to 360 ml) of tap water had cryptosporidiosis confirmed by laboratory tests.	Water	158-163	nuclear RNA export factor 1	Homo sapiens	154-157
10821681-1	2000	Surface balance techniques were used to study the interactions of surfactant protein SP-A with monolayers of surfactant components preformed at the air-water interface.	Water	152-157	surfactant protein A2	Homo sapiens	85-89
10806391-5	2000	Like the apo-structure, the bile-acid complex of ILBP is composed of 10 anti-parallel beta-strands that form a water-filled clam-shell structure, and two short alpha-helices.	Water	111-116	fatty acid binding protein 6	Homo sapiens	49-53
11225875-0	2000	Determination of uranium in tap water by ICP-MS. A fast and accurate procedure has been developed for the determination of uranium at microg L(-1) level in tap and mineral water.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
10771139-7	2000	The potency to induce hsp70 was significantly correlated to the octanol-water partition coefficient (log K(ow)) of the inducing chemicals, except for 1-chloro-2,4-dinitrobenzene and ethyl parathion.	Water	72-77	heat shock protein family A (Hsp70) member 4	Homo sapiens	22-27
10760484-0	2000	Examining the effects of lipopolysaccharide and cholecystokinin on water ingestion: comparing intake and palatability.	Water	67-72	cholecystokinin	Rattus norvegicus	48-63
10760484-6	2000	Both LPS and CCK significantly (p&lt;0.05) reduced water intake, with the effects of combined LPS with CCK being more pronounced than either agent injected alone.	Water	51-56	cholecystokinin	Rattus norvegicus	13-16
10938866-0	2000	Water stress enhances beta-amylase activity in cucumber cotyledons.	Water	0-5	beta-amylase	Cucumis sativus	22-34
10938866-2	2000	Amylolytic activity in the cotyledon was increased about 6-fold by water stress within 1 d. The substrate specificity and the action pattern indicated that beta-amylase is responsible for the activity.	Water	67-72	beta-amylase	Cucumis sativus	156-168
11022436-2	2000	Saline or tap water is often used to loosen the dressing and therefore help to remove it.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
30189517-7	2018	Compared to those who used tap water &lt;50% of the time, mothers who reported using tap water for drinking and cooking &gt;50% of time in their prenatal questionnaire had 8.54 times the odds of using their tap water at 1-year postpartum (95% CI: 5.37, 13.60).	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
10720466-7	2000	Although the crosslink yield is significantly lower under these conditions, due to predominant reaction of the photolabile probes with water, a specific interaction of Arf1 with subunits of coatomer, the major coat protein of COPI vesicles, could readily be identified.	Water	135-140	ADP ribosylation factor 1	Homo sapiens	168-172
30189517-7	2018	Compared to those who used tap water &lt;50% of the time, mothers who reported using tap water for drinking and cooking &gt;50% of time in their prenatal questionnaire had 8.54 times the odds of using their tap water at 1-year postpartum (95% CI: 5.37, 13.60).	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
30189517-7	2018	Compared to those who used tap water &lt;50% of the time, mothers who reported using tap water for drinking and cooking &gt;50% of time in their prenatal questionnaire had 8.54 times the odds of using their tap water at 1-year postpartum (95% CI: 5.37, 13.60).	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
10652914-9	2000	CONCLUSIONS: The use of Gd-DTPA as a positive contrast agent may not be imperative, and T1-weighted FLASH imaging in combination with true FISP imaging with ingestion of tap water can be very useful in evaluating AGC with MR imaging.	Water	174-179	nuclear RNA export factor 1	Homo sapiens	170-173
30189517-8	2018	After adjusting for frequency of prenatal tap water use, mothers were less likely to use tap water for drinking and cooking (OR = 0.34, 95% CI: 0.19, 0.60) and for mixing formula (OR = 0.45, 95% CI: 0.24, 0.86) if the high arsenic concentration (&gt;10 mug/L) was known to them.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	89-92
10820911-1	2000	BACKGROUND: Flickering light and color patterns, reading, language, movement, decision making, eating, tapping and touching, hot water immersion and auditory stimulation can induce seizures in some patients.	Water	129-134	alcohol dehydrogenase iron containing 1	Homo sapiens	125-128
30189517-8	2018	After adjusting for frequency of prenatal tap water use, mothers were less likely to use tap water for drinking and cooking (OR = 0.34, 95% CI: 0.19, 0.60) and for mixing formula (OR = 0.45, 95% CI: 0.24, 0.86) if the high arsenic concentration (&gt;10 mug/L) was known to them.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	42-45
30189517-8	2018	After adjusting for frequency of prenatal tap water use, mothers were less likely to use tap water for drinking and cooking (OR = 0.34, 95% CI: 0.19, 0.60) and for mixing formula (OR = 0.45, 95% CI: 0.24, 0.86) if the high arsenic concentration (&gt;10 mug/L) was known to them.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
30189517-9	2018	Our findings suggest that providing well water test results during pregnancy may reduce subsequent maternal use of iAs contaminated tap water for drinking, cooking, and mixing infant formula.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	132-135
10878506-2	2000	In addition, we have reported that Mg fortification of drinking water can attenuate atherogenesis in male low-density lipoprotein (LDL)-receptor-deficient mice, but had a mild and nonsignificant effect on female mice fed a high-cholesterol diet supplemented with cholic acid.	Water	64-69	low density lipoprotein receptor	Mus musculus	106-144
10878506-11	2000	CONCLUSION: These results confirm that Mg fortification of drinking water is capable of inhibiting atherogenesis also in female LDL-receptor-deficient mice fed a high-cholesterol diet, and demonstrate the importance of the nutritional composition of diet in this experimental model.	Water	68-73	low density lipoprotein receptor	Mus musculus	128-140
30189517-9	2018	Our findings suggest that providing well water test results during pregnancy may reduce subsequent maternal use of iAs contaminated tap water for drinking, cooking, and mixing infant formula.	Water	136-141	nuclear RNA export factor 1	Homo sapiens	132-135
10961683-5	2000	On stabilisation of the water structure in the presence of low ethanol concentrations a stabilisation of the DNA macromolecule occurs that leads to the increase of the Ca2+ ion concentration necessary for DNA compactisation.	Water	24-29	carbonic anhydrase 2	Homo sapiens	168-171
30189556-1	2018	BACKGROUND: Despite the rigorous control of tap water quality, substantial price differences, and environmental concerns, bottled water consumption has increased in recent decades.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
10662522-2	2000	Nap-(Ala-Aib)(4)-NHCH(2)CH(2)NH-Lac was spontaneously dispersed in water and formed aggregates of 70 nm diameter, shown by dynamic light scattering measurement.	Water	67-72	ANIB1	Homo sapiens	9-12
30189556-6	2018	RESULTS: The two consumer groups showed "polarized" ratings regarding perceived quality/hygiene, health risks and taste for bottled and tap water, indicating that the two consumer groups substantially diverged in their beliefs.	Water	140-145	nuclear RNA export factor 1	Homo sapiens	136-139
11045315-12	2000	Our results suggest that AQP-1 and AQP-4 may be important factors in water transport in patients undergoing CAPD.	Water	69-74	aquaporin 4	Homo sapiens	35-40
30555510-9	2018	Water-drinking betaE +/+ females expressed more Gabra2 in central nucleus of the amygdala and the bed nucleus of the stria terminalis than males, but this sex difference was absent in the betaE -/- mice.	Water	0-5	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	Mus musculus	48-54
12038489-5	2000	The penetration of UV and PAR into the water column can be measured.	Water	39-44	jumping translocation breakpoint	Homo sapiens	26-29
11203905-12	2000	Pasteurization of tap water can reduce contamination; this water can be used as acceptable dental treatment water (&lt; 200 CFU/mL).	Water	59-64	nuclear RNA export factor 1	Homo sapiens	18-21
11203905-12	2000	Pasteurization of tap water can reduce contamination; this water can be used as acceptable dental treatment water (&lt; 200 CFU/mL).	Water	59-64	nuclear RNA export factor 1	Homo sapiens	18-21
10666086-2	2000	Uroguanylin has been shown to participate in the regulation of salt and water homeostasis in mammals via cGMP-mediated processes, bearing a distinct similarity to the action of the atriopeptins, which play a defined role in natriuresis and act as prognostic indicators of severe congestive heart failure (CHF).	Water	72-77	guanylate cyclase activator 2B	Homo sapiens	0-11
10679577-10	2000	These results suggested that intracellular H(2)O(2) regulated by Rac and RhoA, but not inositol phosphates, was responsible for the EGF-stimulated elevation of [Ca(2+)](i).	Water	43-48	ras homolog family member A	Rattus norvegicus	73-77
10655103-3	2000	Here we show that mice deficient in aquaporin-4 (AQP4), a glial membrane water channel, have much better survival than wild-type mice in a model of brain edema caused by acute water intoxication.	Water	73-78	aquaporin 4	Mus musculus	36-47
10585303-0	1999	Determination of the extent of excessive copper concentrations in the tap-water of households with copper pipes and an assessment of possible health hazards for infants.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
10655103-3	2000	Here we show that mice deficient in aquaporin-4 (AQP4), a glial membrane water channel, have much better survival than wild-type mice in a model of brain edema caused by acute water intoxication.	Water	73-78	aquaporin 4	Mus musculus	49-53
30501110-0	2018	Design of a Novel and Selective IRAK4 Inhibitor Using Topological Water Network Analysis and Molecular Modeling Approaches.	Water	66-71	interleukin 1 receptor associated kinase 4	Homo sapiens	32-37
10655103-4	2000	Brain tissue water content and swelling of pericapillary astrocytic foot processes in AQP4-deficient mice were significantly reduced.	Water	13-18	aquaporin 4	Mus musculus	86-90
10668728-0	2000	Decreased hemispheric water mobility in hemiplegic migraine related to mutation of CACNA1A gene.	Water	22-27	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	83-90
10585303-4	1999	To determine precisely a possible connection between the amount of copper in tap-water and the risk of early childhood liver disease, an attempt was first made, through an epidemiological survey, to determine the extent of excessive concentrations of copper in the tap-water of households with copper pipes.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
10585303-4	1999	To determine precisely a possible connection between the amount of copper in tap-water and the risk of early childhood liver disease, an attempt was first made, through an epidemiological survey, to determine the extent of excessive concentrations of copper in the tap-water of households with copper pipes.	Water	269-274	nuclear RNA export factor 1	Homo sapiens	265-268
30487383-6	2018	State of the art and promising perspectives are reported considering the chemical-physical component and the biological natural complexity of the spa water microbiota.	Water	150-155	surfactant protein A2	Homo sapiens	146-149
10607425-5	1999	Cyclosporin A inhibits induction of JNK function by TCR/CD28, PMA/ionomycin, ceramide, or H(2)O(2), but not induction by UV light or hyperosmolar sorbitol.	Water	90-95	mitogen-activated protein kinase 8	Mus musculus	36-39
10527588-7	1999	The maximum amounts of water vapor adsorbed by these xerogels were about 600-700 ml(STP)/g and were relatively high compared with those for various other adsorbents reported so far.	Water	23-28	thyroid hormone receptor interactor 10	Homo sapiens	84-87
11140171-2	2000	administered peptide and nonpeptide ANG II-receptor ligands (losartan, EXP 3174, saralasin and sarmesin) on monoamine oxidase A (MAO-A) and MAO-B activities in the frontal cortex, striatum, hypothalamus and hippocampus of water-repleted rats were investigated.	Water	222-227	monoamine oxidase B	Rattus norvegicus	140-145
10689212-6	2000	In the subgroup aged 21 to 60 years, the highest rates of seronegativity were found in individuals with higher level of education living in houses with tap water (66.6%).	Water	156-161	nuclear RNA export factor 1	Homo sapiens	152-155
30338326-1	2018	Cobalt(ii) benzoate trihydrate prepared by the reaction of CoCO3 with benzoic acid (HBz) in boiling water followed by crystallization has been structurally characterized as a chain-like system with the formula unit [Co(Bz)(H2O)2]Bz H2O where the Co(ii) atoms are triply linked by one bridging syn-syn benzoato (Bz) and two aqua ligands; additional benzoate counter ions and solvate water molecules are present in the crystal structure.	Water	100-105	hemoglobin subunit zeta	Homo sapiens	84-87
11146901-3	2000	Whole-body hyperthermic water bath reduced relative total T lymphocyte counts, increased relative CD8+ T lymphocyte and NK cell counts and increased NK activity.	Water	24-29	CD8a molecule	Homo sapiens	98-101
10587314-7	1999	cyclo(-D-Asp1-Asp2-Gly3-Ahd4-Ahd5-Gly6-) (C3) clearly exhibits two different conformations with a shifted beta,beta-turn motif in CDCI3 and SDS/H2O solutions.	Water	144-147	beta-secretase 2	Homo sapiens	9-13
30261166-11	2018	Interestingly the number of interfacial water molecules found in ZmTIM is lower than those observed in most TIMs that show folding intermediates.	Water	40-45	triosephosphate isomerase, cytosolic	Zea mays	65-70
10587314-7	1999	cyclo(-D-Asp1-Asp2-Gly3-Ahd4-Ahd5-Gly6-) (C3) clearly exhibits two different conformations with a shifted beta,beta-turn motif in CDCI3 and SDS/H2O solutions.	Water	144-147	complement C3	Homo sapiens	42-44
10571798-10	1999	As the high tap water concentration of strontium was adequately reduced during the water purification process, contamination of the final dialysis fluid occurred by the addition of concentrates contaminated with strontium.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
10571798-10	1999	As the high tap water concentration of strontium was adequately reduced during the water purification process, contamination of the final dialysis fluid occurred by the addition of concentrates contaminated with strontium.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	12-15
10619865-10	2000	These results indicate that AQP5 is responsible for the majority of water transport across the apical membrane of type I alveolar epithelial cells.	Water	68-73	aquaporin 5	Mus musculus	28-32
10613915-0	2000	Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method.	Water	45-50	aquaporin 4	Mus musculus	8-19
30442970-7	2018	The correlative biochemical analysis demonstrated that reduction of water content during dentin hybridization by the innovative dry-bonding approaches with DMSO is effective to inactivate host-derived MMP-2 and MMP-9 and thus reduce collagen degradation while simultaneously optimizing resin-dentin bonding.	Water	68-73	matrix metallopeptidase 9	Homo sapiens	211-216
10613915-2	2000	In this study, we determined the role of AQP4 in airspace-to-capillary water transport by comparing water permeability in wild-type mice and transgenic null mice lacking AQP1, AQP4, or AQP1/AQP4 together.	Water	71-76	aquaporin 4	Mus musculus	41-45
10653591-6	2000	The strongest PV signal was present in chief cells and water clear cells, whereas in oxyphilic cells only a weak signal was observed.	Water	55-60	parvalbumin	Homo sapiens	14-16
10579058-2	1999	The major epithelial isoforms, NHE2 and NHE3, are thought to have more specialized roles in regulating Na+ and water absorption and are differentially expressed in epithelial tissues.	Water	111-116	solute carrier family 9 member A2	Rattus norvegicus	31-35
30354164-6	2018	However, for OPA/GlyGly system, another different type of product with benzopyrrole structure (OPG) was obtained by nucleophilic substitution via mixing OPA and GlyGly in water, which generated organic nanoparticles.	Water	171-176	basic transcription factor 3 pseudogene 11	Homo sapiens	95-98
10550681-6	1999	Several hydrogen bonds involving active site residues Thr199 and Thr200 as well as three water molecules (Wat99, Wat122, and Wat123) further stabilize the urea-hCA II adduct.	Water	89-94	carbonic anhydrase 2	Homo sapiens	160-166
30425313-8	2018	The main modifiable risk factor identified in this study was the consumption of tap or osmosis drinking water.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	80-83
10489993-12	1999	The association was stronger among men with above-median tap water consumption.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
30232522-5	2018	Additionally, the probe was successfully utilized to determine HClO in tap water, exogenous HClO in HeLa cells, and endogenous HClO in MCF-7 cells with a low detection limit and cytotoxicity.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
10441155-5	1999	On the basis of these findings, the possibility is discussed that the O(2)-dependent conversion of Cytb(559) in PSII complexes lacking a functionally competent WOC is related to a protective role of Cytb(559) in photoinhibition and/or that it is involved in the regulation of the assembly of a competent water-oxidizing complex in PSII.	Water	304-309	mitochondrially encoded cytochrome b	Homo sapiens	99-103
30223332-1	2018	Geosmin (GSM) and 2-methylisoborneol (2-MIB) are two common odor compounds in drinking water.	Water	87-92	MIB E3 ubiquitin protein ligase 1	Homo sapiens	40-43
10454764-1	1999	Guanylin and uroguanylin are peptides that bind to and activate guanylate cyclase C and control salt and water transport in many epithelia in vertebrates, mimicking the action of several heat-stable bacteria enterotoxins.	Water	105-110	guanylate cyclase activator 2A	Rattus norvegicus	0-8
30223332-2	2018	In this paper, the performance of UV/chlorine was compared with that of chlorine and UV to degrade GSM (100 ng L-1) and 2-MIB (100 ng L-1) in water.	Water	142-147	MIB E3 ubiquitin protein ligase 1	Homo sapiens	122-125
10452609-8	1999	In holo I-FABP the fatty acid chain interactions with the hydrophilic side chains are mediated by water molecules.	Water	98-103	fatty acid binding protein 2	Rattus norvegicus	8-14
28612312-5	2018	Tap water in households receiving trucked water contained less than the recommended 0.2 mg/L of free chlorine, while piped drinking water in Iqaluit complied with Health Canada guidelines for residual chlorine (i.e. &gt;0.2 mg/L free chlorine).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
10452609-11	1999	The MD simulation predicts significant structural perturbations of the cavity on the subnanosecond time scale, which are capable of facilitating exchange of I-FABP internal water.	Water	173-178	fatty acid binding protein 2	Rattus norvegicus	157-163
10487144-1	1999	Methemoglobin (MetHb) is an oxidation product of hemoglobin in which the sixth coordination position of ferric iron is bound to a water molecule or to a hydroxyl group.	Water	130-135	hemoglobin subunit gamma 2	Homo sapiens	0-13
28612312-5	2018	Tap water in households receiving trucked water contained less than the recommended 0.2 mg/L of free chlorine, while piped drinking water in Iqaluit complied with Health Canada guidelines for residual chlorine (i.e. &gt;0.2 mg/L free chlorine).	Water	42-47	nuclear RNA export factor 1	Homo sapiens	0-3
10487144-1	1999	Methemoglobin (MetHb) is an oxidation product of hemoglobin in which the sixth coordination position of ferric iron is bound to a water molecule or to a hydroxyl group.	Water	130-135	hemoglobin subunit gamma 2	Homo sapiens	15-20
28612312-5	2018	Tap water in households receiving trucked water contained less than the recommended 0.2 mg/L of free chlorine, while piped drinking water in Iqaluit complied with Health Canada guidelines for residual chlorine (i.e. &gt;0.2 mg/L free chlorine).	Water	42-47	nuclear RNA export factor 1	Homo sapiens	0-3
30218573-3	2018	EAU was induced in B10.A mice by immunization with interphotoreceptor retinoid-binding protein (IRBP).	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	51-94
30218573-3	2018	EAU was induced in B10.A mice by immunization with interphotoreceptor retinoid-binding protein (IRBP).	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	96-100
30305310-0	2018	Bile Acid G Protein-Coupled Membrane Receptor TGR5 Modulates Aquaporin 2-Mediated Water Homeostasis.	Water	82-87	G protein-coupled bile acid receptor 1	Mus musculus	46-50
10400615-1	1999	Aquaporin-5 (AQP5) is a water-selective transporting protein expressed in epithelial cells of serous acini in salivary gland.	Water	24-29	aquaporin 5	Mus musculus	0-11
10400615-1	1999	Aquaporin-5 (AQP5) is a water-selective transporting protein expressed in epithelial cells of serous acini in salivary gland.	Water	24-29	aquaporin 5	Mus musculus	13-17
30305310-11	2018	TGR5 is thus involved in regulating water metabolism in the kidney.	Water	36-41	G protein-coupled bile acid receptor 1	Mus musculus	0-4
30031366-12	2018	Under the synergistic influence of water constituents (including acidity and alkalinity, ion species and dissolved organic substances), various water matrices greatly affected the degradation rate of TC-HCl, with the highest removal efficiency of 78.9% in natural seawater, followed by reservoir water (75.0%), tap water (62.3%), deionized water (49.8%), reverse osmosis concentrate (32.7%) and pharmaceutical wastewater (18.9%).	Water	144-149	nuclear RNA export factor 1	Homo sapiens	311-314
10407152-6	1999	Our previous study showed that the DeltaG of unfolding of W19Y in water is 6.9 kcal/mol smaller than that of wild type beta-LG.	Water	66-71	beta-lactoglobulin	Bos taurus	119-126
30031366-12	2018	Under the synergistic influence of water constituents (including acidity and alkalinity, ion species and dissolved organic substances), various water matrices greatly affected the degradation rate of TC-HCl, with the highest removal efficiency of 78.9% in natural seawater, followed by reservoir water (75.0%), tap water (62.3%), deionized water (49.8%), reverse osmosis concentrate (32.7%) and pharmaceutical wastewater (18.9%).	Water	144-149	nuclear RNA export factor 1	Homo sapiens	311-314
30031366-12	2018	Under the synergistic influence of water constituents (including acidity and alkalinity, ion species and dissolved organic substances), various water matrices greatly affected the degradation rate of TC-HCl, with the highest removal efficiency of 78.9% in natural seawater, followed by reservoir water (75.0%), tap water (62.3%), deionized water (49.8%), reverse osmosis concentrate (32.7%) and pharmaceutical wastewater (18.9%).	Water	144-149	nuclear RNA export factor 1	Homo sapiens	311-314
18967666-6	1999	The developed methods were applied to Cu(II) and Zn(II) determination in natural and tap water.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
30031366-12	2018	Under the synergistic influence of water constituents (including acidity and alkalinity, ion species and dissolved organic substances), various water matrices greatly affected the degradation rate of TC-HCl, with the highest removal efficiency of 78.9% in natural seawater, followed by reservoir water (75.0%), tap water (62.3%), deionized water (49.8%), reverse osmosis concentrate (32.7%) and pharmaceutical wastewater (18.9%).	Water	144-149	nuclear RNA export factor 1	Homo sapiens	311-314
30713694-5	2018	The polymer encapsulation not only enables the water transfer of the NPL stacks but also allows the preparation of photoelectrodes by linking the fibres to surface modified indium tin oxide (ITO) glass slides.	Water	47-52	N-acetylneuraminate pyruvate lyase	Homo sapiens	69-72
10751901-14	1999	Secretin stimulates the releasing of water, bicarbonate and enteropeptidases whereas cholecystokinin acts on pancreatic enzymes.	Water	37-42	secretin	Homo sapiens	0-8
30138703-3	2018	Benefiting from its amphiphilic property, CPT-SS-GEM prodrug could self-assemble into Janus nano-prodrug in water without aid of any excipient.	Water	108-113	choline phosphotransferase 1	Homo sapiens	42-45
10480387-10	1999	From these results, we conclude that BnPIP1 is related to the water transportation required for enzymatic metabolism of storage nutrients at the early stages of canola seed germination whereas Bngamma-TIP2 expression is related to cell growth associated with radicle protrusion.	Water	62-67	aquaporin PIP2-1	Brassica napus	37-43
30264061-1	2018	Water-soluble and fluorescent perylene dyes PMI1 and PMI2 with red to near-infrared (red-NIR) emission and a large Stokes shift were designed and synthesized.	Water	0-5	phosphomannomutase 2	Homo sapiens	44-48
18967646-6	1999	Validation of the method was made by comparison of the results of analyses of tap water by another electrochemical method and by recovery test for river and mineral water.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
30240227-4	2018	After dripping onto a water surface, a drop of ethanol solution of poly(stearyl acrylate- co-acrylic acid) [P(SA- co-AAc)] spread quickly to form a thin film.	Water	22-27	glycine-N-acyltransferase	Homo sapiens	117-120
10399325-0	1999	Sensitive determination of RDX, nitroso-RDX metabolites, and other munitions in ground water by solid-phase extraction and isotope dilution liquid chromatography-atmospheric pressure electro-spray [correction of chemical] ionization mass spectrometry.	Water	87-92	radixin	Homo sapiens	27-30
10399335-7	1999	The repeatability and the reproducibility between days of the method (n = 6), expressed as relative standard deviation, for tap water spiked at a level of 1 ng l-1 were between 5.7 and 25.6% and between 7.6 and 26.5%, respectively.	Water	128-133	nuclear RNA export factor 1	Homo sapiens	124-127
30232494-7	2018	These findings parallel those recently reported for the ST2 model of water near its LLPT, suggesting common signatures that may be useful for identifying similar transitions in other systems.	Water	69-74	ST2	Homo sapiens	56-59
11821591-3	1999	The mean objective reduction in sweat output was 49%, 51%, 26%, and 22% at week 3, 6, 10, and 12, respectively, since the start of treatment with tap water iontophoresis The mean subjective improvements were 43%, 59%, 30%, and 12% at week 3, 6,10, and 12, respectively.	Water	150-155	nuclear RNA export factor 1	Homo sapiens	146-149
11821591-5	1999	We conclude that tap water iontophoresis is a safe and useful treatment modality for palmar hyperhidrosis.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
30199618-1	2018	SnO x thin films were successfully deposited by the thermal atomic layer deposition (ALD) method using N, N"- tert-butyl-1,1-dimethylethylenediamine stannylene(II) as a precursor and ozone and water as reactants.	Water	193-198	strawberry notch homolog 2	Homo sapiens	0-3
30199618-2	2018	The growth of SnO and SnO2 films could be easily controlled by employing different reactants and utilizing different ozone and water concentrations, respectively.	Water	127-132	strawberry notch homolog 2	Homo sapiens	14-17
10228119-3	1999	CPAP was set close to dynamic intrinsic PEEP (8.3 +/- 3.4 cm H2O).	Water	61-64	centromere protein J	Homo sapiens	0-4
30199618-4	2018	The combined studies of density functional theory calculations and experimental analyses showed that the difference in growth behavior of the SnO and SnO2 films can be attributed to the stability of ozone and water on the SnO2 and SnO films.	Water	209-214	strawberry notch homolog 2	Homo sapiens	142-145
10228119-5	1999	However, only the combination of PAV and CPAP brought P0.1 (1.69 +/- 0.97 cm H2O) and PTPdi (100 +/- 68 cm H2O.	Water	77-80	centromere protein J	Homo sapiens	41-45
10228119-5	1999	However, only the combination of PAV and CPAP brought P0.1 (1.69 +/- 0.97 cm H2O) and PTPdi (100 +/- 68 cm H2O.	Water	107-110	centromere protein J	Homo sapiens	41-45
30199618-4	2018	The combined studies of density functional theory calculations and experimental analyses showed that the difference in growth behavior of the SnO and SnO2 films can be attributed to the stability of ozone and water on the SnO2 and SnO films.	Water	209-214	strawberry notch homolog 2	Homo sapiens	150-153
30199618-7	2018	SnO x films formed using ozone and water as a reactant showed an optical band gap of 3.60-3.17 eV and 2.24-2.30 eV and refractive indices of ~2.0 and ~2.6, respectively, which correspond to values typical of SnO2 and SnO.	Water	35-40	strawberry notch homolog 2	Homo sapiens	0-3
30199618-7	2018	SnO x films formed using ozone and water as a reactant showed an optical band gap of 3.60-3.17 eV and 2.24-2.30 eV and refractive indices of ~2.0 and ~2.6, respectively, which correspond to values typical of SnO2 and SnO.	Water	35-40	strawberry notch homolog 2	Homo sapiens	208-211
30219992-6	2018	We proposed that increasing the concentraton of H3O+ resulted in stronger hydrogen bonding between the phosphate oxygens at the water-lipid interface leading to a reduced area per lipid and slightly increased membrane thickness.	Water	128-133	H3 clustered histone 15	Homo sapiens	48-51
11068330-11	2000	Moreover, dehydration induced by drinking 2% NaCl solution and deprivation of drinking water increased calretinin levels in the posterior pituitary as compared with control, but the calbindin level was not changed.	Water	87-92	calbindin 2	Rattus norvegicus	103-113
10337604-1	1999	Tap water in a city like Boston, which has old houses containing lead plumbing, is known to be a significant source of potential lead exposure.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
30219992-9	2018	Further, H3O+ preferentially accumulated at the water-lipid interface, suggesting the localised pH at the membrane surface is much lower than the bulk bathing solution.	Water	48-53	H3 clustered histone 15	Homo sapiens	9-12
30219992-10	2018	Another significant finding was that the hydrogen bonds formed by H3O+ ions with lipid headgroup oxygens are, on average, shorter in length and longer-lived than the ones formed in bulk water.	Water	186-191	H3 clustered histone 15	Homo sapiens	66-69
10683568-7	2000	In the first experiment, there were significant correlations between water maze performance and the number of; (i) choline acetyltransferase- and p75(NTR)-positive neurons in the nucleus basalis magnocellularis; (ii) choline acetyltransferase-positive neurons in the striatum and; (iii) p75(NTR)-positive neurons in the medial septum.	Water	69-74	choline O-acetyltransferase	Rattus norvegicus	115-140
30347264-7	2018	Deletion of AQP4, but not LdcLNs, increased brain water content.	Water	50-55	aquaporin 4	Mus musculus	12-16
10683568-7	2000	In the first experiment, there were significant correlations between water maze performance and the number of; (i) choline acetyltransferase- and p75(NTR)-positive neurons in the nucleus basalis magnocellularis; (ii) choline acetyltransferase-positive neurons in the striatum and; (iii) p75(NTR)-positive neurons in the medial septum.	Water	69-74	choline O-acetyltransferase	Rattus norvegicus	217-242
30085336-1	2018	Aging is associated with impairment of the paravascular pathway caused by the activation of astrocytes and depolarization of protein aquaporin-4 (AQP4) water channels, resulting in the accumulation of protein waste, including amyloid beta (Abeta), in the brain parenchyma.	Water	152-157	aquaporin 4	Mus musculus	133-144
11200982-3	2000	Furthermore, on the Russian space station Mir, we have observed that renal fluid excretion in two astronauts following an oral water load of 600 ml was attenuated compared with that of the acute supine position on the ground.	Water	127-132	membrane associated ring-CH-type finger 8	Homo sapiens	42-45
11203905-8	2000	RESULTS: Pasteurized water was significantly less contaminated than was tap water.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
11203905-12	2000	Pasteurization of tap water can reduce contamination; this water can be used as acceptable dental treatment water (&lt; 200 CFU/mL).	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
30085336-1	2018	Aging is associated with impairment of the paravascular pathway caused by the activation of astrocytes and depolarization of protein aquaporin-4 (AQP4) water channels, resulting in the accumulation of protein waste, including amyloid beta (Abeta), in the brain parenchyma.	Water	152-157	aquaporin 4	Mus musculus	146-150
10842795-9	2000	An overview of input, occurrence, elimination (e.g. biodegradability) and possible effects of different pharmaceutical groups such as anti-tumour drugs, antibiotics and contrast media as well as AOX resulting from hospitals effluent input into sewage water and surface water is presented.	Water	251-256	acyl-CoA oxidase 1	Homo sapiens	195-198
29405337-0	2018	Altered expression of glutamate transporter-1 and water channel protein aquaporin-4 in human temporal cortex with Alzheimer"s disease.	Water	50-55	aquaporin 4	Homo sapiens	72-83
10607459-1	1999	Chloroform in tap water has been a significant problem because it may be a carcinogenic substituent.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
10607459-3	1999	Iron ions in tap water cause discoloration and a bad odor.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
29405337-3	2018	In a previous study, we have demonstrated marked alterations in the expression of the astrocytic water channel protein aquaporin-4 (AQP4) in relation to amyloid beta deposition in human AD brains.	Water	97-102	aquaporin 4	Homo sapiens	119-130
29405337-3	2018	In a previous study, we have demonstrated marked alterations in the expression of the astrocytic water channel protein aquaporin-4 (AQP4) in relation to amyloid beta deposition in human AD brains.	Water	97-102	aquaporin 4	Homo sapiens	132-136
29920457-1	2018	Applying silver nanoparticles (nAg) or silver nitrate (AgNO3) to ceramic water filters improves microbiological efficacy, reduces biofilm formation, and protects stored water from recontamination.	Water	73-78	NBAS subunit of NRZ tethering complex	Homo sapiens	31-34
21662735-11	1999	The ability of the system to do practical analysis was demonstrated by the accurate determination of MMT in spiked samples of gasoline, human urine, and tap water.	Water	157-162	nuclear RNA export factor 1	Homo sapiens	153-156
29920457-1	2018	Applying silver nanoparticles (nAg) or silver nitrate (AgNO3) to ceramic water filters improves microbiological efficacy, reduces biofilm formation, and protects stored water from recontamination.	Water	169-174	NBAS subunit of NRZ tethering complex	Homo sapiens	31-34
30320301-2	2018	The porosity and water vapor affinity of CNF filaments make them suitable for controlled breathability.	Water	17-22	NPHS1 adhesion molecule, nephrin	Homo sapiens	41-44
10567216-13	1999	Phosphorylation of cPLA(2) by H(2)O(2) occurred on Ser-505, a reaction that is known to increase the intrinsic lipase activity of the enzyme.	Water	30-35	phospholipase A2 group IVA	Homo sapiens	19-26
29969132-5	2018	Simulations of water behaviour have been used to probe hydrophobic gates in two recently reported ion channel structures: BEST1 and TMEM175.	Water	15-20	transmembrane protein 175	Homo sapiens	132-139
10585957-1	1999	We present a study of the adsorption of the glucose oxidase enzyme (GOx) at the air/water interface, using the nonlinear optical technique of surface second harmonic generation (SSHG).	Water	84-89	hydroxyacid oxidase 1	Homo sapiens	68-71
30839717-0	2018	Removal of Cr6+ ions from water by electrosorption on modified activated carbon fibre felt.	Water	26-31	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	11-14
10581548-0	1999	GTP plus water mimic ATP in the active site of protein kinase CK2.	Water	9-14	Calcium-dependent protein kinase 6	Zea mays	62-65
10575084-11	1999	Furthermore, FosB expression in the CeMPV and the EW was also significantly higher in the alcohol-consuming animals vs. water controls.	Water	120-125	FBJ osteosarcoma oncogene B	Mus musculus	13-17
30839717-9	2018	In conclusion, the modified ACFF exhibits excellent electrosorption and regeneration performance for Cr6+ removal from water and thus is of great value for promotion in sewage treatment.	Water	119-124	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	101-104
30133282-5	2018	The water molecule is in hydrogen bonding with the nearby anionic Glu111 of IDE but not directly bound to the catalytic Zn ion.	Water	4-9	insulin degrading enzyme	Homo sapiens	76-79
10549650-8	1999	The propensity of B10.RIII mice to mount a more polarized Th1 response to IRBP than other strains may contribute to their ability to develop EAU without pertussis adjuvant.	Water	141-144	retinol binding protein 3, interstitial	Mus musculus	74-78
10518661-1	1999	Insulin loaded PLGA nanospheres having weight mean diameters of 400 nm were prepared by the modified emulsion solvent diffusion method in water.	Water	138-143	insulin	Cavia porcellus	0-7
30237459-3	2018	Nevertheless, the surface water sample collected from backwater area induced the significant increase in expressions of genes (sod-2 and sod-3) encoding Mn-SODs in wild-type nematodes.	Water	26-31	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	127-132
10575352-4	1999	Finally, theoretical and experimental considerations have led us to the conclusion that the functional form of the elastomer, water swollen elastin, could be a triphasic system comprising the protein chains, hydration water and solvent water.	Water	126-131	elastin	Homo sapiens	140-147
10575352-4	1999	Finally, theoretical and experimental considerations have led us to the conclusion that the functional form of the elastomer, water swollen elastin, could be a triphasic system comprising the protein chains, hydration water and solvent water.	Water	218-223	elastin	Homo sapiens	140-147
10575352-4	1999	Finally, theoretical and experimental considerations have led us to the conclusion that the functional form of the elastomer, water swollen elastin, could be a triphasic system comprising the protein chains, hydration water and solvent water.	Water	218-223	elastin	Homo sapiens	140-147
10575352-5	1999	Following this description, the dynamic structural equilibria occurring within elastin hydrophobic domains and the plasticizing effect of water could explain elastin elasticity, in keeping with a classical entropic mechanism.	Water	138-143	elastin	Homo sapiens	158-165
30283424-5	2018	Irrespective of differences in treatment plants, tap water bacterial communities in the distinct networks converged and highly resembled the flushed water communities.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
10549314-0	1999	A hospital outbreak of gastroenteritis possibly related to the contamination of tap water by a small round structured virus.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
30283424-5	2018	Irrespective of differences in treatment plants, tap water bacterial communities in the distinct networks converged and highly resembled the flushed water communities.	Water	149-154	nuclear RNA export factor 1	Homo sapiens	49-52
10561109-12	1999	In contrast, two patients had markedly elevated RLi (17.3 and 17.4 cm H2O/L/sec).	Water	70-73	ATP binding cassette subfamily E member 1	Homo sapiens	48-51
30283424-6	2018	Piping biofilm and sediment communities therefore largely determine the final tap water microbial quality, attenuating the impact of water source and treatment strategy and highlighting the fundamental role of local physicochemical conditions and microbial processes within infrastructure micro-niches.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
30218202-5	2018	The matrix-matching calibration method was performed in order to improve the accuracy of cadmium quantification in tap water and the recovery results obtained were as follows: 88.56 +- 8.92 and 97.43 +- 9.76, for 6.0 and 8.0 ng/mL of cadmium-spiked tap water samples, respectively.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
10579409-3	1999	Tap water was supplied from 2 L cups, 1 cup per pen.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
30086229-9	2018	These features provide a proof of concept for the applicability of the hybrid CNF/TiO2 monoliths for in-flow purification of water under solar illumination, not only for model dyes but also for organic pollutants of high practical relevance.	Water	125-130	NPHS1 adhesion molecule, nephrin	Homo sapiens	78-81
10552714-7	1999	The proposed method has been applied to the determination of paraquat in tap water, milk, and white wine samples with recoveries of 89-104%.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
29879534-6	2018	The radon concentrations in tap water samples were found to be in the range of 0.98 Bq/L-27.28 Bq/L.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
10503706-8	1999	Moreover, it is also shown that the annual effective dose due to inhalation of radon emanating from tap water and flushing water is negligible compared to the total annual dose for indoor radon in Algiers.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
10337625-1	1999	Aquaporin 5 (Aqp5), a member of the aquaporin family of membrane water channels, is thought to modulate the osmolality of fluids in the eye, lung, and salivary gland.	Water	65-70	aquaporin 5	Mus musculus	0-11
10337625-1	1999	Aquaporin 5 (Aqp5), a member of the aquaporin family of membrane water channels, is thought to modulate the osmolality of fluids in the eye, lung, and salivary gland.	Water	65-70	aquaporin 5	Mus musculus	13-17
29958841-9	2018	A molecular modeling study of virodhamine with MAO-B and its cofactor flavin adenine dinucleotide (FAD) predicted virodhamine"s terminal -NH2 group to be positioned near the N5 position of FAD, but for docking to MAO-A, virodhamine"s terminal -NH2 group was far away (~6.52 A) from the N5 position of FAD, and encountered bad contacts with nearby water molecules.	Water	347-352	monoamine oxidase B	Homo sapiens	47-52
12549115-8	1999	Therefore, a method of separation and enrichment by a column packed with tributyl phosphate(TBP) extraction resin was applied for analysis of TZ4 oil field water.	Water	156-161	TATA-box binding protein	Homo sapiens	92-95
12835114-2	1999	In rat primary astrocyte cultures, we demonstrated that dopamine, cysteamine, H(2)O(2) and menadione rapidly induce heme oxygenase-1 (HO-1) expression (mRNA and protein) followed by sequestration of non-transferrin-derived (55)Fe by the mitochondrial compartment.	Water	78-83	heme oxygenase 1	Rattus norvegicus	116-132
12835114-2	1999	In rat primary astrocyte cultures, we demonstrated that dopamine, cysteamine, H(2)O(2) and menadione rapidly induce heme oxygenase-1 (HO-1) expression (mRNA and protein) followed by sequestration of non-transferrin-derived (55)Fe by the mitochondrial compartment.	Water	78-83	heme oxygenase 1	Rattus norvegicus	134-138
29485689-8	2018	Hard water led to increased levels of interleukin (IL)-4, interferon (IFN)-gamma and IL-10.	Water	5-10	interleukin 10	Homo sapiens	85-90
10444521-8	1999	Both H(2)O(2) added exogenously to the cell medium (extracellular H(2)O(2)) and that generated by anti-PECAM-GOX caused oxidative stress manifested by time- and dose-dependent irreversible plasma membrane damage.	Water	5-10	hydroxyacid oxidase 1	Homo sapiens	109-112
10194358-0	1999	The role of water in the catalytic efficiency of triosephosphate isomerase.	Water	12-17	triosephosphate isomerase 1	Gallus gallus	49-74
29027501-1	2018	The aim of this study was synthesis of two new water-soluble fluorescent palladium and platinum complexes with formulas of [Pt(DACH)(FIP)](NO3)2 and [Pd(DACH)(FIP)](NO3)2, respectively, where FIP is 2-(furan-2-yl)-1H-imidazo[4,5-f][1,10] phenanthroline and DACH is 1R,2R-diaminocyclohexane.	Water	47-52	upstream transcription factor 2, c-fos interacting	Homo sapiens	133-136
10394634-4	1999	The accumulation of chitinase in response to inoculation with the pathogen was induced more rapidly in cucumber plants previously treated with acibenzolar-S-methyl than in plants pretreated with SA or water.	Water	201-206	acidic endochitinase	Cucumis sativus	20-29
10423451-1	1999	The orientational order and dynamics of the water molecules in form II crystals of bovine pancreatic trypsin inhibitor (BPTI) are studied by (2)H NMR in the temperature range 6-50 degrees C. From the orientation dependence of the single crystal quadrupole splitting and linewidth, the principal components of the motionally averaged quadrupole interaction tensor and the irreducible linewidth components for the orthorhombic crystal are determined.	Water	44-49	spleen trypsin inhibitor I	Bos taurus	120-124
10468289-6	1999	When PIF from G361 cells was administered to female NMRI mice (20 g) a pronounced depression of body weight (1.36+/-0.36 g; P &lt; 0.0001 from control) was observed over a 24 h period without a decrease in either food or water consumption.	Water	221-226	dermcidin	Homo sapiens	5-8
29027501-1	2018	The aim of this study was synthesis of two new water-soluble fluorescent palladium and platinum complexes with formulas of [Pt(DACH)(FIP)](NO3)2 and [Pd(DACH)(FIP)](NO3)2, respectively, where FIP is 2-(furan-2-yl)-1H-imidazo[4,5-f][1,10] phenanthroline and DACH is 1R,2R-diaminocyclohexane.	Water	47-52	upstream transcription factor 2, c-fos interacting	Homo sapiens	159-162
10454768-2	1999	The aim of this study was to determine the role of magnesium concentration [Mg2+] in AVP-stimulated water transport in the kidney collecting duct.	Water	100-105	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	85-88
10454768-3	1999	The effect of low and high peritubular [Mg2+] on the AVP-stimulated osmotic water permeability coefficient (Pf) was evaluated in the isolated perfused rabbit cortical collecting duct (CCD).	Water	76-81	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	53-56
10053185-7	1999	A higher OMP loading efficiency was achieved by adding NaCl or adjusting the pH at the iso-electric point of OMP in the external water phase.	Water	129-134	olfactory marker protein	Homo sapiens	9-12
10053185-7	1999	A higher OMP loading efficiency was achieved by adding NaCl or adjusting the pH at the iso-electric point of OMP in the external water phase.	Water	129-134	olfactory marker protein	Homo sapiens	109-112
10454768-9	1999	These data indicate that magnesium may play a modulatory role in the action of AVP on CCD osmotic water permeability, as observed in other tissues.	Water	98-103	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	79-82
29027501-1	2018	The aim of this study was synthesis of two new water-soluble fluorescent palladium and platinum complexes with formulas of [Pt(DACH)(FIP)](NO3)2 and [Pd(DACH)(FIP)](NO3)2, respectively, where FIP is 2-(furan-2-yl)-1H-imidazo[4,5-f][1,10] phenanthroline and DACH is 1R,2R-diaminocyclohexane.	Water	47-52	upstream transcription factor 2, c-fos interacting	Homo sapiens	159-162
30243371-2	2018	Following oil spills, cetaceans at the water surface may inhale droplets of oil containing toxic polycyclic aromatic hydrocarbons (PAHs), which could potentially alter respiratory immunity via activation of the aryl hydrocarbon receptor (AHR) and its subsequent interaction with nuclear factor kappa B (NF-kappaB).	Water	39-44	LOC522736	Bos taurus	211-236
10427160-5	1999	Water-deprived maternal rats presented a significant increase in total ANP receptor density in isolated renal glomeruli and adrenal zona glomerulosa membranes.	Water	0-5	natriuretic peptide A	Rattus norvegicus	71-74
16160935-2	1999	The focus is on the application of ab initio SCF quantum mechanical methods to antiarrhythmic-receptor interactions and proton transfer, including the effect of small cations and water.	Water	179-184	KIT ligand	Homo sapiens	45-48
10090207-1	1999	Water adsorption measured by STM.	Water	0-5	sulfotransferase family 1A member 3	Homo sapiens	29-32
10090207-2	1999	When operating scanning probe microscopes, like STM or AFM, under ambient conditions, the presence of water on the sample and the tip always plays an important role.	Water	102-107	sulfotransferase family 1A member 3	Homo sapiens	48-51
30243371-2	2018	Following oil spills, cetaceans at the water surface may inhale droplets of oil containing toxic polycyclic aromatic hydrocarbons (PAHs), which could potentially alter respiratory immunity via activation of the aryl hydrocarbon receptor (AHR) and its subsequent interaction with nuclear factor kappa B (NF-kappaB).	Water	39-44	LOC522736	Bos taurus	238-241
10090207-3	1999	The water not only influences the structure of the sample itself, but also the imaging process; in the case of the STM using a wet etched w-tip, by interfering with the electron transfer process, and in the case of the AFM, due to the capillary forces in the micro Newton range that dominate the tip surface interaction forces.	Water	4-9	sulfotransferase family 1A member 3	Homo sapiens	115-118
10090207-4	1999	In this paper, the distribution and the amount of adsorbed water on different surfaces is investigated with the help of the STM, which can provide information by imaging and by current/distance spectroscopy.	Water	59-64	sulfotransferase family 1A member 3	Homo sapiens	124-127
10383382-0	1999	Competitive, reversible inhibition of cytosolic phospholipase A2 at the lipid-water interface by choline derivatives that partially partition into the phospholipid bilayer.	Water	78-83	phospholipase A2 group IVA	Homo sapiens	38-64
30078496-8	2018	In addition, a case study of Taipei City indicated that MSW disposal fees should reflect not only household population (P) but also tap water penetration (W).	Water	136-141	nuclear RNA export factor 1	Homo sapiens	132-135
10501018-2	1999	A colorimetric method was used on purified water-soluble mucin extracted from mucosal scrapings and contents.	Water	43-48	solute carrier family 13 member 2	Rattus norvegicus	57-62
30120299-2	2018	The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expression of the perivascular astroglial water channel aquaporin-4 (AQP4).	Water	174-179	aquaporin 4	Homo sapiens	201-205
10383614-3	1999	Exposure to water or removal of the vomeronasal organ suppressed the expression of Fos-ir cells.	Water	12-17	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-86
9895414-5	1999	A linear constant release of Fmoc-Trp(Boc) and its water-soluble PLGA oligomer conjugates was observed over an extended period without any initial burst effect, while unconjugated Fmoc-Trp(Boc) encapsulated within microspheres exhibited a rapid release profile.	Water	51-56	BOC cell adhesion associated, oncogene regulated	Homo sapiens	29-42
9950950-13	1999	Thus VACM-1 may be involved in the regulation of endothelial permeability and water transport in the CT.	Water	78-83	cullin-5	Oryctolagus cuniculus	5-11
9915811-2	1999	The kinetics of PI-PLCgamma1 toward a water-soluble substrate (inositol 1,2-cyclic phosphate, cIP) and phosphatidylinositol (PI) in detergent mixed micelles were monitored by 31P NMR spectroscopy.	Water	38-43	muscular LMNA interacting protein	Homo sapiens	94-97
10552586-0	1999	Major degradation pathway of thiuram in tap water processed by oxidation with sodium hypochlorite.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
10552586-4	1999	Subsequently, it was suggested that monitoring of bis(dimethylcarbamoyl) disulfide, its trisulfide, and dimethylamine should be included for the management and control of thiuram in tap water processed by oxidation with sodium hypochlorite.	Water	186-191	nuclear RNA export factor 1	Homo sapiens	182-185
29758863-4	2018	In this study, we depict absolute particle size composition of suspended sediment and sink sediment in the water-level fluctuation zone, and these are interpreted in the context of flow regulation controls on sediment sorting.	Water	107-112	tribbles pseudokinase 3	Homo sapiens	86-90
10393343-7	1999	Loss of or altered hydrogen bond interactions involving the water molecules bridging the sialic acid to the protein was found to be the major cause for the observed drop in CT-B affinity in the smaller derivatives, while in the bulkier derivatives, hydrophobic interactions with the protein were found to partly compensate for these losses.	Water	60-65	phosphate cytidylyltransferase 1B, choline	Homo sapiens	173-177
29758863-7	2018	Sink sediment collected from the water-level fluctuation zone during a single summer flood event displayed a similar longitudinal fining trend, reflecting preferential settling of coarser fractions in the backwater reaches where flow velocity declines sharply.	Water	33-38	tribbles pseudokinase 3	Homo sapiens	0-4
10383875-0	1999	Chronic poisoning by copper in tap water: I.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
9915811-10	1999	A key hypothesis is that there is a pH-dependent conformational change in the enzyme that controls accessibility of the active site to both water-soluble cIP and interfacially organized PI.	Water	140-145	muscular LMNA interacting protein	Homo sapiens	154-157
30104609-12	2018	MD simulations indicate the importance of I93 residue from the TM2 segment of ZmPIP2;5 for the increased water transport in ZmPIP1;2.	Water	105-110	aquaporin PIP2-5	Zea mays	78-86
9878676-1	1999	Water deprivation induces expression of the immediate early gene c-fos in specific brain regions, most likely as a result of the activation of cells that are responsive to changes in osmolality and/or blood volume.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-70
10383875-3	1999	Copper in tap water has caused a series of severe systemic diseases in Germany in recent years (copper induced liver cirrhosis).	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
10383875-4	1999	Besides cirrhosis, another type of disease with predominantly gastrointestinal symptoms has occurred which likewise appeared to be induced by copper in tap water.	Water	156-161	nuclear RNA export factor 1	Homo sapiens	152-155
10383876-0	1999	Chronic poisoning by copper in tap water: II.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
10383876-3	1999	Copper in tap water has caused a series of severe systemic diseases in Germany in recent years (chronic copper poisoning, CCuP).	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
10383879-2	1999	Incorrect application of copper tubes in households may lead to elevated copper concentrations in tap water.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
30082638-8	2018	After adjusting for confounders, the occurrence of diarrhoea was statistically significantly associated with sourcing water from an indoor tap (Adjusted Odds Ratio (AOR): 2.73, 95% CI: 2.73, 1.14-6.56) and storing cooked/perishable food in non-refrigerated conditions (AOR: 2.17, 95% CI: 2.17, 1.44-3.26).	Water	118-123	nuclear RNA export factor 1	Homo sapiens	139-142
10387039-5	1999	We infer that the side chains of the residues at the 11 reactive loci (D80, L81, V83, V87, P89, W90, V91, V92, L94, E95, V96) are on the water-accessible surface of the binding-site crevice and that 9 of these are occluded by bound antagonist.	Water	137-142	inner membrane mitochondrial protein	Homo sapiens	91-94
10400067-5	1999	In spontaneously hypotensive animals, A beta infusion resulted in substantial increases in MA beta compared to vehicle distilled water infusion.	Water	129-134	amyloid beta precursor protein	Rattus norvegicus	38-44
10023623-3	1999	Detection limits down to 0.1-4 micrograms l-1 were obtained for spiked tap water following a preconcentration step.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
29952605-5	2018	An elevation of Fos-like immunoreactivity in Ox neurons was observed in fluid-depleted rats that were allowed to ingest water and sodium.	Water	120-125	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-19
9887005-2	1999	We previously reported that secretin, a hormone known to stimulate ductal bile secretion, increases cholangiocyte osmotic water permeability and stimulates the redistribution of AQP1 from an intracellular vesicular pool to the cholangiocyte plasma membrane.	Water	122-127	secretin	Rattus norvegicus	28-36
10382996-5	1999	RESULTS: A single systemic injection of Ad.RSV-ANP at a dose of 1.2x10(10) pfu results in a significant increase in urine excretion, water intake, urinary sodium and potassium excretion.	Water	133-138	natriuretic peptide A	Rattus norvegicus	47-50
29948709-6	2018	The result shows that NWD made from tap water helps the engine to reduce nitrogen oxide (NOx) by 32%.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
10328818-1	1999	Cytosolic phospholipase A2 (cPLA2) is normally located in the cytosol, but in response to cellular activation the enzyme binds to the membrane at the lipid/water interface where it catalyzes the hydrolysis of the sn-2 ester of arachidonate-containing phospholipids.	Water	156-161	phospholipase A2 group IVA	Homo sapiens	0-26
29655889-6	2018	TLP-1 from water elution possessed of higher reducing power and scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, superoxide radical and hydroxyl radical than TLP-2 eluted by 0.1M of NaCl.	Water	11-16	telomerase associated protein 1	Homo sapiens	0-5
10328818-1	1999	Cytosolic phospholipase A2 (cPLA2) is normally located in the cytosol, but in response to cellular activation the enzyme binds to the membrane at the lipid/water interface where it catalyzes the hydrolysis of the sn-2 ester of arachidonate-containing phospholipids.	Water	156-161	phospholipase A2 group IVA	Homo sapiens	28-33
10229903-4	1999	Iodine in tap water obtained from 55 different locations in Denmark varied from &lt;1.0 to 139 microg/l.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
29907217-17	2018	Moreover, hydrogen-rich water caused Nrf2 to enter the cell nucleus, which resulted in increases in the expression of downstream factors such as HO-1 and NQO1.	Water	24-29	heme oxygenase 1	Rattus norvegicus	145-149
10229903-7	1999	A statistically significant correlation was found between tap water iodine content today and the urinary iodine excretion measured in 41 towns in 1967 (r=0.68, P&lt;0.001).	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
10229903-10	1999	We found that iodine in tap water was a major determinant of regional differences in iodine intake in Denmark.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
28627088-2	2018	This prospective observational study explored whether expression of the water channel aquaporin-4 (AQP4) and the anchoring molecule dystrophin 71 (Dp71) are altered at astrocytic perivascular endfeet and in adjacent neuropil of iNPH patient.	Water	72-77	aquaporin 4	Homo sapiens	99-103
30008899-1	2018	N-acetyl-L-cysteine (NAC) is the most abundant water-soluble component of garlic.	Water	47-52	X-linked Kx blood group	Homo sapiens	21-24
30060820-10	2018	Thus, the decrease in AQP1 protein levels in the endothelium and AQP5 in gland ductal cells of irradiated animals may have hindered the removal of water from the lumen of ductal cells, inducing a delay in water absorption and triggering a slight lumen increase.	Water	147-152	aquaporin 5	Rattus norvegicus	65-69
29972642-5	2018	Functional surfaces were then generated by the adsorption of two model enzymes that can convert phenol and its derivatives (laccase and tyrosinase), well known as high-risk pollutants of drinking and natural water.	Water	208-213	tyrosinase	Homo sapiens	136-146
30084797-4	2018	By adding the PEG2000-SH and the C13 carbon chain to a NIR representative dye IR780, the new formed material PEG-IR780-C13 shows good solubility in water.	Water	148-153	homeobox C13	Homo sapiens	33-36
30084797-4	2018	By adding the PEG2000-SH and the C13 carbon chain to a NIR representative dye IR780, the new formed material PEG-IR780-C13 shows good solubility in water.	Water	148-153	homeobox C13	Homo sapiens	119-122
29998279-1	2018	In this investigation, we examine the effect of water concentration and temperature on the dynamical properties of [Hmim][Cl] and [Hmim][NTf2] ionic liquids (ILs).	Water	48-53	nuclear transport factor 2	Homo sapiens	137-141
29998279-4	2018	At low, intermediate and high water concentrations, the following trend in diffusion coefficients is seen: Cl- &gt; Hmim+; Cl- &gt; NTf2-; Hmim+ ([Hmim][Cl]) &gt; Hmim+ ([Hmim] [NTf2]).	Water	30-35	nuclear transport factor 2	Homo sapiens	132-136
29998279-4	2018	At low, intermediate and high water concentrations, the following trend in diffusion coefficients is seen: Cl- &gt; Hmim+; Cl- &gt; NTf2-; Hmim+ ([Hmim][Cl]) &gt; Hmim+ ([Hmim] [NTf2]).	Water	30-35	nuclear transport factor 2	Homo sapiens	178-182
29998279-6	2018	The effect of an increase in the water concentration leads to a decrease in ion-pair lifetimes between the Hmim+ cations and Cl-/NTf2- anions, which strongly correlates with the trends observed from the diffusion coefficients.	Water	33-38	nuclear transport factor 2	Homo sapiens	129-133
29998279-9	2018	The rotational correlation time of water molecules is larger in [Hmim][Cl] compared to that in [Hmim][NTf2] at low and intermediate water concentrations, with similar correlation times observed at high water concentrations.	Water	35-40	nuclear transport factor 2	Homo sapiens	102-106
29998279-9	2018	The rotational correlation time of water molecules is larger in [Hmim][Cl] compared to that in [Hmim][NTf2] at low and intermediate water concentrations, with similar correlation times observed at high water concentrations.	Water	132-137	nuclear transport factor 2	Homo sapiens	102-106
29998279-9	2018	The rotational correlation time of water molecules is larger in [Hmim][Cl] compared to that in [Hmim][NTf2] at low and intermediate water concentrations, with similar correlation times observed at high water concentrations.	Water	132-137	nuclear transport factor 2	Homo sapiens	102-106
30010166-3	2018	The water soluble dinuclear copper complex (Cu(DAT)) was obtained by mixing a 1 : 1 ratio of Cu(OTf)2 and DAT in water.	Water	4-9	POU class 2 homeobox 2	Homo sapiens	93-101
29400462-3	2018	Herein, we described the use of Cu(OTf)2 as a very efficient catalyst for the synthesis of CP in water at room temperature.	Water	97-102	POU class 2 homeobox 2	Homo sapiens	32-40
29902377-9	2018	This investigation suggests water-main biofilms may serve as a source of Legionella for tap water and premise plumbing systems, and residual chloramine may aid in reducing their abundance.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	88-91
29902377-9	2018	This investigation suggests water-main biofilms may serve as a source of Legionella for tap water and premise plumbing systems, and residual chloramine may aid in reducing their abundance.	Water	92-97	nuclear RNA export factor 1	Homo sapiens	88-91
29771702-7	2018	The role of brain aquaporin-4 in mediating water entry into the brain is further clarified.	Water	43-48	aquaporin 4	Homo sapiens	18-29
29793778-4	2018	MATERIAL AND METHODS: PDS sheet material was water-heated and preformed using a template based on a statistical anatomical model.	Water	45-50	solute carrier family 26 member 4	Homo sapiens	22-25
29875071-1	2018	The presence of water disinfection byproducts (DBPs) in tap water, resulting from disinfection processes involving chlorination or chloramination, increases the mutagenicity of the water and may pose adverse health effects.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
29875071-4	2018	Studies, primarily using the Salmonella mutagenicity assay, have continued to show that chlorination or chloramination of source waters results in finished, tap, or swimming pool/spa water that is more mutagenic than the original source water.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	157-160
30045535-8	2018	MBG and 2,4-DAT were also detected in surface water which was impacted by waste water, while 4,2,1-AIMT could not be detected in any sample.	Water	46-51	solute carrier family 6 member 3	Homo sapiens	12-15
30004780-0	2018	Spin-Isomer Conversion of Water at Room Temperature and Quantum-Rotor-Induced Nuclear Polarization in the Water-Endofullerene H_{2}O@C_{60}.	Water	26-31	spindlin 1	Homo sapiens	0-4
16303407-11	1999	Patients more frequently washed their storage cases in tap water than controls (P&lt;0.05) with resulting contamination, kept storage cases wet rather than air drying them (P&lt;0.05), and had coliform bacteria cultured from the storage case (P&lt;0.05) and had viable Acanthamoeba within the storage case (P&lt;0.0001).	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
16303407-17	1999	CONCLUSIONS: Failure to disinfect contact lenses, non-compliant use of chlorine tablets and/or introduction of tap water rinsing of storage cases were associated with increased risk of Acanthamoeba infection.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
30004780-0	2018	Spin-Isomer Conversion of Water at Room Temperature and Quantum-Rotor-Induced Nuclear Polarization in the Water-Endofullerene H_{2}O@C_{60}.	Water	106-111	spindlin 1	Homo sapiens	0-4
30004780-1	2018	Water exists in two forms, para and ortho, that have nuclear spin states with different symmetries.	Water	0-5	spindlin 1	Homo sapiens	61-65
29949852-0	2018	Properties and Stability of Perilla Seed Protein-Stabilized Oil-in-Water Emulsions: Influence of Protein Concentration, pH, NaCl Concentration and Thermal Treatment.	Water	67-72	microseminoprotein beta	Homo sapiens	28-48
10377881-5	1999	The third (exogenous) level mechanisms have been found in the study of the lymphocytic functions of cyanobacterial exometabolites and their derivatives from tap water probes.	Water	161-166	nuclear RNA export factor 1	Homo sapiens	157-160
29949852-1	2018	Perilla seed protein (PSP) was extracted from defatted perilla seed meal and applied in oil-in-water (O/W) emulsions as an emulsifier.	Water	95-100	microseminoprotein beta	Homo sapiens	0-20
29949852-1	2018	Perilla seed protein (PSP) was extracted from defatted perilla seed meal and applied in oil-in-water (O/W) emulsions as an emulsifier.	Water	95-100	microseminoprotein beta	Homo sapiens	22-25
9829992-4	1998	Enzymatic activities and kinetic analysis of the pure enzyme forms showed that wild type LCAT and both mutants were reactive with the water-soluble substrate, p-nitrophenyl butyrate, indicating the presence of an intact core active site and catalytic triad.	Water	134-139	lecithin-cholesterol acyltransferase	Homo sapiens	89-93
29934501-1	2018	This paper details an investigation into the characteristic "plink" sound produced by water droplets impacting a liquid surface, such as those falling from a dripping tap.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	167-170
10325294-6	1999	Water content was markedly increased in rabbits treated with DHEA-S + 1 mg HA compared with DHEA-S + 0.1 mg HA treatment (P &lt; 0.05).	Water	0-5	sulfotransferase family 2A member 1	Homo sapiens	61-67
29575414-3	2018	The T1 lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na+ /K+ ATPase transporters.	Water	50-55	solute carrier family 2 member 1	Homo sapiens	148-153
10325294-6	1999	Water content was markedly increased in rabbits treated with DHEA-S + 1 mg HA compared with DHEA-S + 0.1 mg HA treatment (P &lt; 0.05).	Water	0-5	sulfotransferase family 2A member 1	Homo sapiens	92-98
10232700-1	1999	Several aquaporin-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the collecting duct; AQP6 in the papilla; and AQP7 in the proximal tubule.	Water	23-28	aquaporin 4	Mus musculus	155-159
9894347-0	1998	Comparative study of a solid-phase extraction system coupled to capillary electrophoresis in the determination of haloacetic compounds in tap water.	Water	142-147	nuclear RNA export factor 1	Homo sapiens	138-141
29885663-11	2018	Administration of rh-Aggf1 significantly reduced brain water content and BBB permeability, decreased the numbers of infiltrating neutrophils, and activated microglia in the ipsilateral cerebral cortex following SAH.	Water	55-60	angiogenic factor with G patch and FHA domains 1	Rattus norvegicus	21-26
9836590-4	1998	Specifically, the spectral properties of secretin in water were examined as a function of peptide concentration.	Water	53-58	secretin	Homo sapiens	41-49
10065532-4	1998	In addition, the solid adducts obtained from aqueous solutions at pH = 3-4 of the above interactions correspond to formulae; (Et2Sn)2(5"-IMP)2(H2O) and (Et2Sn)3(5"-GMP)2(OH)2(H2O)2 as their elemental analysis show.	Water	143-146	5'-nucleotidase, cytosolic II	Homo sapiens	164-167
11864472-1	1999	OBJECTIVE: To study the harmful effects of organic concentrates from tap water on mammal animals in vivo.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
11864472-8	1999	It suggested that organic pollutants concentrated from tap water had potential carcinogenic effects on mammal animals.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
29679549-9	2018	The water-soluble prodrug of CHM-1 (CHM-1-P) was synthesized.	Water	4-9	chondromodulin	Homo sapiens	29-34
10092523-2	1999	The osmotic water permeability coefficient (Pf) of X. laevis oocytes expressing the gene cloned from the Sigma1278b strain (AQY1-1) was 5.7 times higher than the Pf of oocytes expressing the gene cloned from other strains (AQY1-2).	Water	12-17	Aqy1p	Saccharomyces cerevisiae S288C	124-128
10092523-3	1999	Aqy1-1p, initially cloned without its C-terminus (Aqy1-1DeltaCp), mediated an approximately 3 times higher water permeability than the full-length protein.	Water	107-112	Aqy1p	Saccharomyces cerevisiae S288C	0-4
10092523-3	1999	Aqy1-1p, initially cloned without its C-terminus (Aqy1-1DeltaCp), mediated an approximately 3 times higher water permeability than the full-length protein.	Water	107-112	Aqy1p	Saccharomyces cerevisiae S288C	50-54
9824541-8	1998	Aquaporin-4 is involved in cerebrospinal fluid transport in brain, water transport in the kidney collecting duct, aqueous humor transport in the eye, and airway hydration in the lung.	Water	67-72	aquaporin 4	Homo sapiens	0-11
9813278-4	1998	administration of neurotensin protects the gastric mucosa against injury caused by cold water restraint (CWR) and also inhibits gastrin-stimulated gastric acid secretion.	Water	88-93	neurotensin	Rattus norvegicus	18-29
9813278-8	1998	Neurotensin reduced cold water restraint (CWR)-induced gastric mucosal injury and inhibited gastrin-stimulated acid secretion.	Water	25-30	neurotensin	Rattus norvegicus	0-11
29679549-9	2018	The water-soluble prodrug of CHM-1 (CHM-1-P) was synthesized.	Water	4-9	chondromodulin	Homo sapiens	36-43
29526439-8	2018	VNC-TNC deviations were correlated with aortic enhancement and patient water equivalent diameter (PWED).	Water	71-76	tenascin C	Homo sapiens	4-7
9853126-3	1998	We report that non-invasive administration of corticosterone in the drinking water (400 micrograms/ml) also produced atrophy of apical dendrites in CA3.	Water	77-82	carbonic anhydrase 3	Rattus norvegicus	148-151
10220922-2	1999	The optimum pH value for the extraction of the HTDPs from fortified tap water at 2 micrograms/l is 3.0.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
29602018-3	2018	For this purpose, 35 mg of caffeine were given to six healthy volunteers after a 10 h overnight together with 240 mL of tap water either on a fasted stomach or 30 min after the high-caloric, high-fat breakfast recommended for bioavailability/bioequivalence (BA/BE) studies.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
11670874-0	1999	Test of Electron Delocalization Effects on Water-Proton Spin-Lattice Relaxation by Bromination of [Tetrakis(4-sulfonatopheny)porphine]manganese.	Water	43-48	spindlin 1	Homo sapiens	56-60
11670874-1	1999	The potential value of electron spin delocalization as a means for substantially increasing the ability of a paramagnetic metal complex to induce nuclear spin relaxation of water protons has been examined by covalent attachment of bromine atoms in the beta-pyrrole positions of the [5,10,15,20-tetrakis(4-sulfonatophenyl)-21H,23H-porphine]manganese complexes[Mn(III)TPPS](3)(-) and [Mn(II)TPPS].	Water	173-178	spindlin 1	Homo sapiens	32-36
11670874-1	1999	The potential value of electron spin delocalization as a means for substantially increasing the ability of a paramagnetic metal complex to induce nuclear spin relaxation of water protons has been examined by covalent attachment of bromine atoms in the beta-pyrrole positions of the [5,10,15,20-tetrakis(4-sulfonatophenyl)-21H,23H-porphine]manganese complexes[Mn(III)TPPS](3)(-) and [Mn(II)TPPS].	Water	173-178	spindlin 1	Homo sapiens	154-158
11670874-2	1999	(4)(-) The water-proton spin-lattice relaxivities are reported as a function of magnetic field strength for the brominated and nonbrominated metalloporphyrins over the range of magnetic field strengths corresponding to proton Larmor frequencies between 0.01 and 30 MHz.	Water	11-16	spindlin 1	Homo sapiens	24-28
9791058-11	1998	Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states.	Water	117-122	cholecystokinin	Rattus norvegicus	43-46
29735091-1	2018	Tap water is used in France to reconstitute powder infant formula, although it is not sterile and possibly contaminated by microbiological and chemical hazards.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
9927773-3	1998	All the patients were evaluated before and after the application of nasal CPAP with a pressure of 12.9 +/- 4.35 cm of H2O with a FIO2 of 21%.	Water	118-121	centromere protein J	Homo sapiens	74-78
9886662-7	1998	These studies reveal significant changes in SAR for applicator configurations involving low dielectric constant (Er) layers on either side of a high Er water bolus layer.	Water	152-157	sarcosine dehydrogenase	Homo sapiens	44-47
10073616-10	1999	AQP3 and AQP4 are basolateral water channels located in the kidney collecting duct, and AQP6 and AQP7 appear to be expressed at lower abundance at several sites including the proximal tubule.	Water	30-35	aquaporin 4	Homo sapiens	9-13
10072507-10	1999	Interestingly, pregnant mice that received an infusion of IRBP-primed lymphoid cells from nonpregnant donors also developed reduced EAU, suggesting that pregnancy suppresses not only the generation, but also the function of mature uveitogenic effector T cells.	Water	132-135	retinol binding protein 3, interstitial	Mus musculus	58-62
9839995-2	1998	The difference between the experimental and theoretical spatial response function (SRF) of a narrow tube with water is used for a localization test for magnetic resonance spectroscopic imaging (MRSI).	Water	110-115	serum response factor	Homo sapiens	83-86
9830712-1	1998	The identification of alkylphosphonic acids in spiked tap water has been investigated by on-line capillary electrophoresis-UV spectrometry-mass spectrometry (CE-UV-MS) in negative-ion mode.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
9776190-13	1998	CONCLUSIONS: Showering, hair rinsing, and head submersion in clean tap water do not promote water entry into the middle ear.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
9825786-4	1998	Although 18% and 31% of subjects, respectively, denied any tap water consumption at home or work, all but one from each cohort responded positively to having at least one possible alternate source of tap water ingestion such as using tap water to brush teeth or drinking tap water offered in a restaurant.	Water	204-209	nuclear RNA export factor 1	Homo sapiens	200-203
9825786-4	1998	Although 18% and 31% of subjects, respectively, denied any tap water consumption at home or work, all but one from each cohort responded positively to having at least one possible alternate source of tap water ingestion such as using tap water to brush teeth or drinking tap water offered in a restaurant.	Water	204-209	nuclear RNA export factor 1	Homo sapiens	200-203
9825786-4	1998	Although 18% and 31% of subjects, respectively, denied any tap water consumption at home or work, all but one from each cohort responded positively to having at least one possible alternate source of tap water ingestion such as using tap water to brush teeth or drinking tap water offered in a restaurant.	Water	204-209	nuclear RNA export factor 1	Homo sapiens	200-203
9825786-4	1998	Although 18% and 31% of subjects, respectively, denied any tap water consumption at home or work, all but one from each cohort responded positively to having at least one possible alternate source of tap water ingestion such as using tap water to brush teeth or drinking tap water offered in a restaurant.	Water	204-209	nuclear RNA export factor 1	Homo sapiens	200-203
9792092-0	1998	Cluster analysis of consensus water sites in thrombin and trypsin shows conservation between serine proteases and contributions to ligand specificity.	Water	30-35	coagulation factor II, thrombin	Bos taurus	45-53
9792092-1	1998	Cluster analysis is presented as a technique for analyzing the conservation and chemistry of water sites from independent protein structures, and applied to thrombin, trypsin, and bovine pancreatic trypsin inhibitor (BPTI) to locate shared water sites, as well as those contributing to specificity.	Water	240-245	coagulation factor II, thrombin	Bos taurus	157-165
9792092-1	1998	Cluster analysis is presented as a technique for analyzing the conservation and chemistry of water sites from independent protein structures, and applied to thrombin, trypsin, and bovine pancreatic trypsin inhibitor (BPTI) to locate shared water sites, as well as those contributing to specificity.	Water	240-245	spleen trypsin inhibitor I	Bos taurus	180-215
9792092-1	1998	Cluster analysis is presented as a technique for analyzing the conservation and chemistry of water sites from independent protein structures, and applied to thrombin, trypsin, and bovine pancreatic trypsin inhibitor (BPTI) to locate shared water sites, as well as those contributing to specificity.	Water	240-245	spleen trypsin inhibitor I	Bos taurus	217-221
9792092-3	1998	Water sites were clustered for ten superimposed thrombin structures, three trypsin structures, and four BPTI structures.	Water	0-5	coagulation factor II, thrombin	Bos taurus	48-56
9792092-3	1998	Water sites were clustered for ten superimposed thrombin structures, three trypsin structures, and four BPTI structures.	Water	0-5	spleen trypsin inhibitor I	Bos taurus	104-108
9792092-4	1998	For thrombin, 19% of the 708 microclusters, representing unique water sites, contained water molecules from at least half of the structures, and 4% contained waters from all 10.	Water	64-69	coagulation factor II, thrombin	Bos taurus	4-12
9792092-7	1998	There were significant overlaps between thrombin and trypsin conserved water sites, which did not localize to their similar active sites, but were concentrated in buried regions including the solvent channel surrounding the Na+ site in thrombin, which is associated with ligand selectivity.	Water	71-76	coagulation factor II, thrombin	Bos taurus	236-244
9792092-8	1998	Cluster analysis also identified water sites conserved in thrombin but not trypsin, and vice versa, providing a list of water sites that may contribute to ligand discrimination.	Water	33-38	coagulation factor II, thrombin	Bos taurus	58-66
9792092-8	1998	Cluster analysis also identified water sites conserved in thrombin but not trypsin, and vice versa, providing a list of water sites that may contribute to ligand discrimination.	Water	120-125	coagulation factor II, thrombin	Bos taurus	58-66
9737849-8	1998	Furthermore, the ligand-binding pocket of apo-CRABPII showed evidence of dynamic disorder; among the 21 residues that constitute this pocket, 16 residues had weak or no detectable cross-peaks in the two-dimensional 1H-15N HSQC spectrum recorded under conditions of minimal water saturation or dephasing.	Water	273-278	cellular retinoic acid binding protein 2	Homo sapiens	46-53
9876290-1	1998	In the present study we evaluated the nature of angiotensin receptors involved in the antidiuretic effect of angiotensin-(1-7) (Ang-(1-7)) in water-loaded rats.	Water	142-147	angiogenin	Rattus norvegicus	128-136
9876290-5	1998	A-779 and Losartan completely blocked the effect of Ang-(1-7) on water diuresis (2.93 +/- 0.34 ml/60 min and 3.39 +/- 0.58 ml/60 min, respectively).	Water	65-70	angiogenin	Rattus norvegicus	52-60
9732068-10	1998	Patients perceive drinking water to be a substantial risk factor for infectious diarrhea and incur significant expense to avoid tap water.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	128-131
9780732-0	1998	[Guanylin family: new intestinal peptides regulating salt and water homeostasis].	Water	62-67	guanylate cyclase activator 2A	Rattus norvegicus	1-9
9780732-7	1998	Guanylin peptide family links the intestine with the kidney and could play the physiological roles in the control of water and electrolyte balance.	Water	117-122	guanylate cyclase activator 2A	Rattus norvegicus	0-8
9807928-5	1998	The results show that the respondents were aware that hand pump/tap water is safe and took care to use these safe sources for drinking purposes.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
9779003-1	1998	In this paper, we investigated the inhibitory effects of water extracts from sixty-six natural medicines on the enzymes related to the skin, which were tyrosinase, hyaluronidase and collagenase.	Water	57-62	tyrosinase	Homo sapiens	152-162
9708891-2	1998	A pentameric bundle of unconstrained helices (residues 6-28 of Vpu) with a water filled pore was initially assembled in a membrane mimetic octane/water system.	Water	75-80	Vpu	Human immunodeficiency virus 1	63-66
9708891-2	1998	A pentameric bundle of unconstrained helices (residues 6-28 of Vpu) with a water filled pore was initially assembled in a membrane mimetic octane/water system.	Water	146-151	Vpu	Human immunodeficiency virus 1	63-66
9793363-2	1998	METHODS: In this work, considering the high toxicity of low quantity of Arsenic ion, a comparative research has been made in order to determine, by using high level liquid Cromatography (HPCL), the quantity in ppm of As hydro- and acid soluble given by five ionomeric products, in water and in nitric acid concentrated solution.	Water	281-286	2-hydroxyacyl-CoA lyase 1	Homo sapiens	187-191
9670208-5	1998	Captopril, 250 mg/ml in drinking water, prevented the injury-induced increase in clusterin mRNA at 7 and 28 days.	Water	33-38	clusterin	Rattus norvegicus	81-90
9688282-6	1998	The RafY channel appears to be wide and water filled and has a small selectivity for cations over anions.	Water	40-45	glycoporin	Escherichia coli	4-8
9618467-1	1998	For analyzing the mechanism of energy transduction in the "motor" protein, myosin, it is opportune both to model the structural change in the hydrolytic transition, ATP (myosin-bound) + H2O --&gt; ADP.Pi (myosin-bound) and to check the plausibility of the model by appropriate site-directed mutations in the functional system.	Water	186-189	myosin, heavy chain 10, non-muscle	Gallus gallus	75-81
9618467-1	1998	For analyzing the mechanism of energy transduction in the "motor" protein, myosin, it is opportune both to model the structural change in the hydrolytic transition, ATP (myosin-bound) + H2O --&gt; ADP.Pi (myosin-bound) and to check the plausibility of the model by appropriate site-directed mutations in the functional system.	Water	186-189	myosin, heavy chain 10, non-muscle	Gallus gallus	170-176
9618467-1	1998	For analyzing the mechanism of energy transduction in the "motor" protein, myosin, it is opportune both to model the structural change in the hydrolytic transition, ATP (myosin-bound) + H2O --&gt; ADP.Pi (myosin-bound) and to check the plausibility of the model by appropriate site-directed mutations in the functional system.	Water	186-189	myosin, heavy chain 10, non-muscle	Gallus gallus	170-176
9672024-1	1998	Within 3 hours of induction of acute hydrocephalus in a canine model, lateral ventricular CSF pressure increased from an initial average of 14.6 +/- 2.8 cm H2O to 40.2 +/- 5.7 cm H2O.	Water	156-159	colony stimulating factor 2	Canis lupus familiaris	90-93
9672024-1	1998	Within 3 hours of induction of acute hydrocephalus in a canine model, lateral ventricular CSF pressure increased from an initial average of 14.6 +/- 2.8 cm H2O to 40.2 +/- 5.7 cm H2O.	Water	179-182	colony stimulating factor 2	Canis lupus familiaris	90-93
9629537-0	1998	A beta-lactam inhibitor of cytosolic phospholipase A2 which acts in a competitive, reversible manner at the lipid/water interface.	Water	114-119	phospholipase A2 group IVA	Homo sapiens	27-53
9707289-0	1998	CCK(B) receptors in the periaqueductal grey are involved in electroacupuncture antinociception in the rat cold water tail-flick test.	Water	111-116	cholecystokinin	Rattus norvegicus	0-3
9689641-3	1998	Cytokines were measured by ELISA in eyes from EAU-induced Lewis rats immunized with interphotoreceptor retinoid-binding protein (IRBP), and compared to eyes from rats immunized with adjuvant only and from normal rats.	Water	46-49	retinol binding protein 3	Rattus norvegicus	84-127
9689641-3	1998	Cytokines were measured by ELISA in eyes from EAU-induced Lewis rats immunized with interphotoreceptor retinoid-binding protein (IRBP), and compared to eyes from rats immunized with adjuvant only and from normal rats.	Water	46-49	retinol binding protein 3	Rattus norvegicus	129-133
9652120-4	1998	The method was used to determine haloacetic acids in chlorine tap water using the liquid-liquid extraction process.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
9654364-2	1998	Previous studies have revealed that UCN mRNA exists in the supraoptic nucleus (SON), and that water deprivation increases UCN immunoreactivity in SON.	Water	94-99	urocortin	Rattus norvegicus	122-125
9612221-9	1998	These studies demonstrate selective expression of AQP1, AQP3, AQP4, and AQP5 in distinct ocular epithelia, predicting specific roles for each in the complex network through which water movements occur in the eye.	Water	179-184	aquaporin 4	Homo sapiens	62-66
9654799-6	1998	Opposition to fluoridation was lower among those who believed their tap water was fluoridated (even if not): 19.9% vs 34.5%, p &lt; 0.001.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
9682675-8	1998	Binding kinetic studies demonstrated downregulation of liver V1a and kidney V2 receptors in deoxycorticosterone acetate-salt rats compared with water-control and salt-control rats (P &lt; 0.05).	Water	144-149	arginine vasopressin receptor 1A	Rattus norvegicus	61-64
9585066-1	1998	The anti-tumor effects of hypoosmotic solution of MTX in distilled water (DW) on Dunn osteosarcoma were evaluated in mouse air pouches.	Water	67-72	metaxin 1	Mus musculus	50-53
9644340-5	1998	Tap water should not be used to rinse any respiratory therapy equipment.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
9578982-9	1998	Inhibition of AVP release has been reported and the physiologic significance of AM"s ability to inhibit water drinking and salt appetite has been established.	Water	104-109	adrenomedullin	Homo sapiens	80-82
9559655-0	1998	Solution conformation of an ET(B) selective agonist, ET-1[Cys(Acm)1,15,Ala3,Leu7,Aib11], in CD3OH/H2O by 1H NMR and molecular modelling.	Water	98-101	ANIB1	Homo sapiens	81-84
9497312-3	1998	However, because humans with defective AQP1 are phenotypically normal and because the ocular application of phorbol esters reduce intraocular pressure, we postulated that the water channel activity of AQP4 may be regulated by these agents.	Water	175-180	aquaporin 4	Homo sapiens	201-205
9497312-8	1998	Moreover, they suggest important potential roles for AQP4 in several clinical disorders involving rapid water transport such as glaucoma, brain edema, and swelling of premature infant lungs.	Water	104-109	aquaporin 4	Homo sapiens	53-57
9566708-6	1998	These results indicate that space restriction and water-immersion stress induced cell proliferation in the glandular stomach through overexpression of proto-oncogenes and increased ODC and SAT activities that might be related to the promotion of gastric carcinogenesis.	Water	50-55	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	189-192
9480810-7	1998	Mutational analysis along with functional assays show that, in contrast to the replacement of His263 and His368, the replacement of the His at position 377 with Gly, Ala, or Ser obliterates LCAT activity with interfacial and water-soluble substrates, thus indicating a role of His377 in catalysis.	Water	225-230	lecithin-cholesterol acyltransferase	Homo sapiens	190-194
9486146-0	1998	Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice.	Water	22-27	aquaporin 4	Mus musculus	79-90
9486146-10	1998	Coexpression of AQP3 and AQP4 in Xenopus laevis oocytes showed additive water permeabilities, suggesting that AQP4 deletion does not affect AQP3 function.	Water	72-77	aquaporin 4 L homeolog	Xenopus laevis	25-29
9486146-11	1998	These results indicate that AQP4 is responsible for the majority of basolateral membrane water movement in IMCD but that its deletion is associated with a very mild defect in urinary concentrating ability.	Water	89-94	aquaporin 4	Mus musculus	28-32
21644759-8	1998	Enthalpy-entropy compensation revealed that the main parameters determining retention in the range of the water fraction (0.2-0.7) increased as follows:  free methanol   solute solvation &gt; methanol/water cluster   solute solvation &gt; RP18 stationary phase   solute interaction.	Water	201-206	pre-mRNA processing factor 3	Homo sapiens	239-243
9432970-0	1998	Assessment of water use for estimating exposure to tap water contaminants.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	51-54
9432970-0	1998	Assessment of water use for estimating exposure to tap water contaminants.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
9432970-1	1998	Epidemiological studies examining the association between exposure to tap water contaminants (such as chlorination by-products) and disease outcomes (such as cancer and adverse reproductive outcomes) have been limited by inaccurate exposure assessment.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
9432970-2	1998	Failure to take into account the variation in beverage and tap water consumption and exposure to volatile contaminants through inhalation and dermal absorption can introduce misclassification in assessing the association between exposure to tap water contaminants and health.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
9432970-2	1998	Failure to take into account the variation in beverage and tap water consumption and exposure to volatile contaminants through inhalation and dermal absorption can introduce misclassification in assessing the association between exposure to tap water contaminants and health.	Water	245-250	nuclear RNA export factor 1	Homo sapiens	241-244
9432970-3	1998	To refine exposure assessment of tap water contaminants, we describe in detail the tap water consumption, showering, and bathing habits of pregnant women and their male partners as assessed by a questionnaire and a 3-day water diary.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
9432970-3	1998	To refine exposure assessment of tap water contaminants, we describe in detail the tap water consumption, showering, and bathing habits of pregnant women and their male partners as assessed by a questionnaire and a 3-day water diary.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
9432970-5	1998	Half of the participants consumed tap water on a regular basis with an overall mean +/- 1 standard deviation (SD) of 0.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
9524329-5	1998	Treatment with RP3 selectively and sufficiently depleted the circulating neutrophil population, markedly reduced MPO, and significantly attenuated LPO and the tissue water content after both 3- and 5-hr of ischemia.	Water	166-171	microtubule-associated protein, RP/EB family, member 3	Rattus norvegicus	15-18
9459580-0	1998	Probing the water permeability of ROMK1 and amphotericin B channels using Xenopus oocytes.	Water	12-17	potassium inwardly rectifying channel subfamily J member 1 S homeolog	Xenopus laevis	34-39
27388647-3	1998	Interestingly, the N-alkyl derivatives (C1-5) had greater water solubility than 1, although increasing alkyl chain length decreased the solubility.	Water	58-63	placenta associated 8	Homo sapiens	40-44
12456181-1	1998	Crystals were detected in glass bottles containing autoclaved (standard cycle: 1218 C, 17 lb/in2, for 20 min) tap water.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	110-113
9421437-15	1998	These results suggest that, in the central nervous system, PTHrP(1-34) is involved in AVP secretion through a novel receptor distinct from the PTH/PTHrP receptors reported previously, playing a role in the body water and electrolyte homeostasis.	Water	211-216	parathyroid hormone-like hormone	Rattus norvegicus	59-64
9588991-5	1998	CONCLUSIONS: The plasticizing effect of absorbed water molecules explains the general decrease in FSp of immersed relined specimens.	Water	49-54	C-X-C motif chemokine ligand 1	Homo sapiens	98-101
10806828-3	1998	The results showed that Huangdan capsule could postpone the increase in the levels of cGMP and ANP, suggesting that by regulating the water and sodium metabolism, Huangdan capsule could ameliorate the glomerular filtration rate, and that Huangdan capsule could lower the levels of cGMP and ANP in plasma via body regulation.	Water	134-139	natriuretic peptide A	Rattus norvegicus	95-98
10806828-3	1998	The results showed that Huangdan capsule could postpone the increase in the levels of cGMP and ANP, suggesting that by regulating the water and sodium metabolism, Huangdan capsule could ameliorate the glomerular filtration rate, and that Huangdan capsule could lower the levels of cGMP and ANP in plasma via body regulation.	Water	134-139	natriuretic peptide A	Rattus norvegicus	290-293
9929412-5	1999	Increasing the effective length of the surfactant head group by adding CmG2 to water-CkOC2OCk-CmbetaG1 mixtures moves the phase behavior dramatically up in temperature when even small amounts of CmG2 are used.	Water	79-84	ANTXR cell adhesion molecule 2	Homo sapiens	71-75
9929412-5	1999	Increasing the effective length of the surfactant head group by adding CmG2 to water-CkOC2OCk-CmbetaG1 mixtures moves the phase behavior dramatically up in temperature when even small amounts of CmG2 are used.	Water	79-84	ANTXR cell adhesion molecule 2	Homo sapiens	195-199
10205644-7	1999	The OMP release rate shows some relations with the porous and water-swollen inner structure of the microspheres matrix.	Water	62-67	olfactory marker protein	Homo sapiens	4-7
9882643-10	1999	During systemic acidosis, apical gill NHE-2 (which is sensitive to external amiloride and low [Na+]) in parallel with a dramatic suppression of basolateral NHE-1 activity enhances net capdelta H+ transfers to the water.	Water	213-218	solute carrier family 9 member A2	Homo sapiens	38-43
9889323-5	1999	Water intake partially decreased ANG I-induced Fos-ir in the SON and PVN, but not in the other areas.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	47-50
9920801-1	1999	Malic dehydrogenase (MDH) studied in water and reversed micelles upon pressure application revealed a difference in catalysis.	Water	37-42	malate dehydrogenase 2	Homo sapiens	0-19
9920801-1	1999	Malic dehydrogenase (MDH) studied in water and reversed micelles upon pressure application revealed a difference in catalysis.	Water	37-42	malate dehydrogenase 2	Homo sapiens	21-24
9920801-2	1999	Whereas MDH in water appeared to be not sensitive to the pressure increasing, the catalytic activity of MDH in reversed micelles showed bell-shaped dependencies both on pressure and surfactant hydration degree, w0.	Water	15-20	malate dehydrogenase 2	Homo sapiens	8-11
10087497-1	1999	Subject of this work is the analysis of molecular dynamics (MD) trajectories of neurophysins I (NPI) and II (NPII) and their complexes with the neurophyseal nonapeptide hormones oxytocin (OT) and vasopresssin (VP), respectively, simulated in water.	Water	242-247	oxytocin/neurophysin I prepropeptide	Homo sapiens	80-107
9873221-6	1999	Each calculus was subjected to a water flow of 2 liters/24 h. The capacity of the Anticolana Valley (Fiuggi) water to dissolve human and synthetic calculi was found to be much higher than that of distilled water which in turn was significantly more effective than tap (ACEA) water.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	264-267
9873221-6	1999	Each calculus was subjected to a water flow of 2 liters/24 h. The capacity of the Anticolana Valley (Fiuggi) water to dissolve human and synthetic calculi was found to be much higher than that of distilled water which in turn was significantly more effective than tap (ACEA) water.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	264-267
9873221-6	1999	Each calculus was subjected to a water flow of 2 liters/24 h. The capacity of the Anticolana Valley (Fiuggi) water to dissolve human and synthetic calculi was found to be much higher than that of distilled water which in turn was significantly more effective than tap (ACEA) water.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	264-267
10613514-9	1999	We conclude that aquaporin-4 messenger RNA is present in a collection of structures typically involved in the regulation of water and sodium intake and that aquaporin-4 water channels could be the osmosensor mechanism responsible for detecting changes in cell volume by these cells.	Water	124-129	aquaporin 4	Homo sapiens	17-28
10645146-4	1999	THP plays an important role in ion transport and in maintaining water impermeability of the TALH and also protects the urinary system from uropathogens.	Water	64-69	uromodulin	Homo sapiens	0-3
9836478-0	1998	The renal effects of the water-soluble, non-folylpolyglutamate synthetase-dependent thymidylate synthase inhibitor ZD9331 in mice.	Water	25-30	thymidylate synthase	Mus musculus	84-104
9854881-3	1998	The descriptive epidemiology, attack rates, a case control study, and the detection of oocysts in the water suggested strongly that the outbreak was associated with drinking unboiled tap water that originated from one deep chalk borehole.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	183-186
9854881-3	1998	The descriptive epidemiology, attack rates, a case control study, and the detection of oocysts in the water suggested strongly that the outbreak was associated with drinking unboiled tap water that originated from one deep chalk borehole.	Water	187-192	nuclear RNA export factor 1	Homo sapiens	183-186
10052620-8	1998	Positive NOESY cross-peaks were measured between the water protons and the H2 protons of A15, A16 and A17 reflecting the occurrence of hydration water molecules with residence times longer than 500 picoseconds along the minor groove of the TTT/AAA segment.	Water	145-150	immunoglobulin kappa variable 1-32 (pseudogene)	Homo sapiens	89-92
10052620-11	1998	In contrast, the widening of the minor groove at the A11:T14 base-pair ending the TTTA/TAAA segment, likely associated to a high negative propeller twist value at this base-pair, prevents the binding of a water molecule with long residence time to A11 but not to A15 of the preceding T10:A15 base-pair.	Water	205-210	immunoglobulin kappa variable 1-32 (pseudogene)	Homo sapiens	263-266
10052620-11	1998	In contrast, the widening of the minor groove at the A11:T14 base-pair ending the TTTA/TAAA segment, likely associated to a high negative propeller twist value at this base-pair, prevents the binding of a water molecule with long residence time to A11 but not to A15 of the preceding T10:A15 base-pair.	Water	205-210	immunoglobulin kappa variable 1-32 (pseudogene)	Homo sapiens	288-291
10052620-12	1998	Thus, in our non-palindromic oligonucleotide the water molecules bind differently to A11 and A15 although both adenines are part of a TpA step.	Water	49-54	immunoglobulin kappa variable 1-32 (pseudogene)	Homo sapiens	93-96
9924918-8	1998	These results indicate that systemic administration of IFN-alpha/beta suppresses IRBP-induced EAU in rats, and suggest that such suppression may be mediated in part by a reduction in TNF-alpha production.	Water	94-97	interferon alpha	Mus musculus	55-64
9924918-8	1998	These results indicate that systemic administration of IFN-alpha/beta suppresses IRBP-induced EAU in rats, and suggest that such suppression may be mediated in part by a reduction in TNF-alpha production.	Water	94-97	retinol binding protein 3	Rattus norvegicus	81-85
9804827-1	1998	A cDNA for a water-soluble chlorophyll (Chl) protein (WSCP) from cauliflower (Brassica oleracea L. var botrys) was cloned and sequenced.	Water	13-18	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	54-58
9822113-1	1998	Several aquaporin-type water channels are expressed in mammalian kidney and lung: AQP1 in lung microvessels and kidney proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 in apical membrane of collecting duct epithelium; AQP3 and AQP4 in basolateral membranes of airway and collecting duct epithelium; and AQP5 in alveolar epithelium.	Water	23-28	aquaporin 4	Homo sapiens	247-251
9806820-1	1998	A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress.	Water	232-237	nitric oxide synthase 3	Rattus norvegicus	50-54
9876928-9	1998	This suggests that the sulfhydryl group of Cys121 may contribute to the maintenance of BLG tertiary structure via water mediated H-bonding.	Water	114-119	beta-lactoglobulin	Bos taurus	87-90
18967359-7	1998	Sample digestion for water with low organic content such as tap water and clean ground water and some clean surface water can be omitted.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	60-63
9825786-4	1998	Although 18% and 31% of subjects, respectively, denied any tap water consumption at home or work, all but one from each cohort responded positively to having at least one possible alternate source of tap water ingestion such as using tap water to brush teeth or drinking tap water offered in a restaurant.	Water	204-209	nuclear RNA export factor 1	Homo sapiens	200-203
9825786-4	1998	Although 18% and 31% of subjects, respectively, denied any tap water consumption at home or work, all but one from each cohort responded positively to having at least one possible alternate source of tap water ingestion such as using tap water to brush teeth or drinking tap water offered in a restaurant.	Water	204-209	nuclear RNA export factor 1	Homo sapiens	200-203
9825786-4	1998	Although 18% and 31% of subjects, respectively, denied any tap water consumption at home or work, all but one from each cohort responded positively to having at least one possible alternate source of tap water ingestion such as using tap water to brush teeth or drinking tap water offered in a restaurant.	Water	204-209	nuclear RNA export factor 1	Homo sapiens	200-203
9825786-4	1998	Although 18% and 31% of subjects, respectively, denied any tap water consumption at home or work, all but one from each cohort responded positively to having at least one possible alternate source of tap water ingestion such as using tap water to brush teeth or drinking tap water offered in a restaurant.	Water	204-209	nuclear RNA export factor 1	Homo sapiens	200-203
9825786-4	1998	Although 18% and 31% of subjects, respectively, denied any tap water consumption at home or work, all but one from each cohort responded positively to having at least one possible alternate source of tap water ingestion such as using tap water to brush teeth or drinking tap water offered in a restaurant.	Water	204-209	nuclear RNA export factor 1	Homo sapiens	200-203
9825786-6	1998	Our findings indicate that it is possible to stratify the population into subsets by the amount of tap water consumed.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
9825786-7	1998	This suggests that an observational epidemiologic study of the risk of contracting cryptosporidiosis from everyday tap water consumption is feasible.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
10065878-5	1998	Central administration (icv) of GLP-1 (7-36) amide produces a marked reduction in food and water intake, and the colocalization of the GLP-1 receptor, GLUT-2, and glucokinase mRNAs in hypothalamic neurons involved in glucose sensing suggests that these cells may be involved in the transduction of signals needed to produce a state of fullness.	Water	91-96	glucagon	Rattus norvegicus	32-37
9751227-7	1998	Finally, when 2 microg of GLP-1 were injected into the third ventricle, it only suppressed water deprivation-induced water intake and failed to influence spontaneous food and water intakes or induce conditioned taste aversion.	Water	117-122	glucagon	Rattus norvegicus	26-31
9751227-8	1998	These observations indicate that GLP-1 is a potent inhibitor of water intake in the rat and may play a role in the control of fluid homeostasis.	Water	64-69	glucagon	Rattus norvegicus	33-38
9730882-6	1998	We also find drug-induced polyuria in mrp1(-/-) mice, which correlates with the presence of mrp1 protein in the urinary collecting tubules, the major site of kidney water reabsorption.	Water	165-170	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	38-42
9757125-0	1998	Crystallization and preliminary X-ray diffraction studies on the water soluble form of rat heme oxygenase-1 in complex with heme.	Water	65-70	heme oxygenase 1	Rattus norvegicus	91-107
9757125-1	1998	The water-soluble portion of rat heme oxygenase-1 which lacks 22 hydrophobic amino-acid residues at the C-terminus was expressed in E. coli and crystallized in the form of a complex with heme by the vapor-diffusion method using polyethylene glycol 4000 as the precipitant.	Water	4-9	heme oxygenase 1	Rattus norvegicus	33-49
10904559-0	1998	Water role in STM imaging of organic films.	Water	0-5	sulfotransferase family 1A member 3	Homo sapiens	14-17
9732402-7	1998	Oocytes injected with Npt1-cRNA demonstrated significantly enhanced transport activity for other anionic compounds such as [14C]faropenem, [14C]foscarnet and [3H]mevalonic acid, as well as [14C]PCG, compared with water-injected oocytes.	Water	213-218	solute carrier family 17 (sodium phosphate), member 1	Mus musculus	22-26
9733114-3	1998	A control treatment was normal tap water and the other three treatments comprised the addition to the tap water of 1,000 mg/L sodium as NaCl, 5,000 mg/L NH4Cl, or 5,000 mg/L KHCO3, supplied from age 2 to 47 d. At Day 28, equally sized subsets of these groups were moved to individual cages, where they received a severe exposure to ambient cold.	Water	106-111	nuclear RNA export factor 1	Homo sapiens	102-105
9816675-6	1998	When mRNAs of gamma- and delta-VM23 were injected into Xenopus oocytes, the osmotic water permeability of oocytes increased 6-fold (60 to 200 microns s-1) of the control oocytes.	Water	84-89	aquaporin TIP2-1	Raphanus sativus	25-35
9681978-9	1998	Analyses of tap water revealed lead values under 0.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
9716475-1	1998	The water-surfactant cross-relaxation indicates a water approach to the first CF2 segment in the order of 2.0 A and a short (&lt;&lt;ns) water residence time.	Water	5-10	ATPase H+ transporting accessory protein 1	Homo sapiens	79-82
9716475-1	1998	The water-surfactant cross-relaxation indicates a water approach to the first CF2 segment in the order of 2.0 A and a short (&lt;&lt;ns) water residence time.	Water	51-56	ATPase H+ transporting accessory protein 1	Homo sapiens	79-82
9701570-4	1998	Expression of ZmTIP1 in Xenopus laevis oocytes showed that it increased the osmotic water permeability of oocytes 5-fold; this water transport was inhibited by mercuric chloride.	Water	84-89	aquaporin TIP1-1	Zea mays	14-20
9701570-4	1998	Expression of ZmTIP1 in Xenopus laevis oocytes showed that it increased the osmotic water permeability of oocytes 5-fold; this water transport was inhibited by mercuric chloride.	Water	127-132	aquaporin TIP1-1	Zea mays	14-20
9701570-9	1998	The high ZmTIP1 expression in meristems and expanding cells suggests that ZmTIP1 is needed (a) for vacuole biogenesis and (b) to support the rapid influx of water into vacuoles during cell expansion.	Water	157-162	aquaporin TIP1-1	Zea mays	9-15
9701570-9	1998	The high ZmTIP1 expression in meristems and expanding cells suggests that ZmTIP1 is needed (a) for vacuole biogenesis and (b) to support the rapid influx of water into vacuoles during cell expansion.	Water	157-162	aquaporin TIP1-1	Zea mays	74-80
9701571-0	1998	High expression of the tonoplast aquaporin ZmTIP1 in epidermal and conducting tissues of maize Aquaporins are integral membrane proteins of the tonoplast and the plasma membrane that facilitate the passage of water through these membranes.	Water	210-215	aquaporin TIP1-1	Zea mays	43-49
9701571-4	1998	We postulate that the high level of expression of ZmTIP1 in these tissues facilitates rapid flow of water through the tonoplast to permit osmotic equilibration between the cytosol and the vacuolar content, and to permit rapid transcellular water flow through living cells when required.	Water	101-106	aquaporin TIP1-1	Zea mays	51-57
9701571-4	1998	We postulate that the high level of expression of ZmTIP1 in these tissues facilitates rapid flow of water through the tonoplast to permit osmotic equilibration between the cytosol and the vacuolar content, and to permit rapid transcellular water flow through living cells when required.	Water	241-246	aquaporin TIP1-1	Zea mays	51-57
9684546-11	1998	In addition to specific new bands due to antigens, both GOX and SAL sensors exhibited changes in the regions of water absorptions at approximately 3500 and 850 cm-1 when the antigens were present.	Water	112-117	hydroxyacid oxidase 1	Homo sapiens	56-59
9873425-0	1998	Neuronorm is a potent and water soluble neurokinin A receptor antagonist.	Water	26-31	tachykinin receptor 2	Rattus norvegicus	40-61
9873425-1	1998	We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm.	Water	89-94	tachykinin receptor 2	Rattus norvegicus	103-124
9761855-2	1998	The final model of HBP consists of 221 amino-acid residues of 225 possible, three glycosylation units, one chloride ion, 15 precipitant ethanol molecules and 323 water molecules.	Water	162-167	azurocidin 1	Homo sapiens	19-22
9689004-1	1998	There is accumulating evidence that adrenomedullin (ADM) is involved in the control of salt and water homeostasis.	Water	96-101	adrenomedullin	Rattus norvegicus	36-50
9689004-1	1998	There is accumulating evidence that adrenomedullin (ADM) is involved in the control of salt and water homeostasis.	Water	96-101	adrenomedullin	Rattus norvegicus	52-55
10065925-3	1998	Sucrose concentration (0.03-0.6 M, corresponding to 1-20%) and ethanol concentration (0-4%) were gradually increased in tap water and in a 0.6 M (ca.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
9707354-2	1998	They received one 20 mg manidipine dihydrochloride tablet with 100 ml of tap water after a standard breakfast.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
9713324-1	1998	To investigate the responsiveness of renal-synthesized C-type natriuretic peptide (CNP) to changes in water and electrolyte balance, we measured renal CNP mRNA levels, plasma CNP concentrations and urinary CNP excretion rates in streptozotocin-induced diabetic rats eating a normal (0.26% NaCl) or low (0.04% NaCl) salt diet.	Water	102-107	natriuretic peptide C	Rattus norvegicus	55-81
9713324-1	1998	To investigate the responsiveness of renal-synthesized C-type natriuretic peptide (CNP) to changes in water and electrolyte balance, we measured renal CNP mRNA levels, plasma CNP concentrations and urinary CNP excretion rates in streptozotocin-induced diabetic rats eating a normal (0.26% NaCl) or low (0.04% NaCl) salt diet.	Water	102-107	natriuretic peptide C	Rattus norvegicus	83-86
9713324-5	1998	These results imply that renal-synthesized CNP is responsive to the alteration of water and electrolyte homeostasis in diabetic rats.	Water	82-87	natriuretic peptide C	Rattus norvegicus	43-46
9712179-11	1998	These findings suggest that endogenous Ang-(l-7) participates in the control of hydroelectrolyte balance by modulating water excretion, acting at tubular and glomerular sites.	Water	119-124	angiogenin	Rattus norvegicus	39-42
9609701-2	1998	Folding and stability studies of the third fibronectin type III domain from human tenascin (TNfn31-90) have shown that it is moderately stable (Delta G(D-N)(H2O) approximately 5 kcal mol-1) and folds with two-state kinetics.	Water	157-160	tenascin C	Homo sapiens	82-90
9841555-8	1998	The demonstration of MCT1 on the apical membrane and MCT3 on the basal membrane identifies specific proteins involved in the discriminate and critical regulation of water and lactate transport from the retina to the choroid.	Water	165-170	solute carrier family 16 member 3	Rattus norvegicus	53-57
9678543-3	1998	DHEAS was administered by gavage (44 mg/rat/day) or in the chow (133 mg/rat/day) to LT- and DM-prone rats from 30 to 120 days of life; some of these rats also received iodine in the drinking water to enhance the incidence and intensity of LT. Onset of DM requiring protamine zinc insulin and its maintenance dose were assessed.	Water	191-196	sulfotransferase family 2A member 1	Homo sapiens	0-5
9647377-3	1998	METHODS: In 21 consecutive patients, 5 to 10 mL of 1.5% acetic acid was sprayed onto the distal esophagus using a spray catheter, followed immediately by spraying 50 mL of tap water.	Water	176-181	nuclear RNA export factor 1	Homo sapiens	172-175
12293742-10	1998	The provision of clean tap-water and facilities to deworm pre-school children would also be welcomed.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
9648224-2	1998	A water-soluble free radical initiator, 2,2"-azobis-amidinopropane dihydrochloride (AAPH), inhibited the activity of plasma LCAT as a function of the incubation time after its addition.	Water	2-7	lecithin-cholesterol acyltransferase	Homo sapiens	124-128
9621221-10	1998	High SCC and the associated higher proteolytic activity caused higher protein loss in the whey and wash water and more curd fines.	Water	104-109	SCC	Bos taurus	5-8
9617685-0	1998	Multi-resistant Pseudomonas aeruginosa outbreak associated with contaminated tap water in a neurosurgery intensive care unit.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
9617685-4	1998	P. aeruginosa O11 with the same resistance pattern was isolated from tap water.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
9617685-6	1998	DNA macrorestriction analysis with XbaI established the similarity of the isolates from patients, tap water and solutions.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
9617685-8	1998	The sinks were presumably the main source of P. aeruginosa during this outbreak, via the hands of the nursing staff or nutrition solutions contaminated with tap water.	Water	161-166	nuclear RNA export factor 1	Homo sapiens	157-160
9615408-2	1998	Water quality monitoring is particularly important for the Mir water supply because approximately half of the water consumed is recovered from humidity condensate.	Water	0-5	membrane associated ring-CH-type finger 8	Homo sapiens	59-62
9615408-2	1998	Water quality monitoring is particularly important for the Mir water supply because approximately half of the water consumed is recovered from humidity condensate.	Water	63-68	membrane associated ring-CH-type finger 8	Homo sapiens	59-62
9615408-7	1998	Results show that Shuttle water is of distilled quality, and Mir recovered water contains various levels of minerals imparted during the recovery processes as designed.	Water	75-80	membrane associated ring-CH-type finger 8	Homo sapiens	61-64
9568683-1	1998	In the rat, the glucagon-like peptide 1 (GLP-1)(7-36) amide inhibits neurones in the central nervous system responsible for food and water intake.	Water	133-138	glucagon	Rattus norvegicus	16-39
9568683-1	1998	In the rat, the glucagon-like peptide 1 (GLP-1)(7-36) amide inhibits neurones in the central nervous system responsible for food and water intake.	Water	133-138	glucagon	Rattus norvegicus	41-46
9568683-8	1998	The inhibitory effect of GLP-1 on water intake was tested using an ANG II-elicited drinking paradigm.	Water	34-39	glucagon	Rattus norvegicus	25-30
9534980-8	1998	Water handling and chlorination on the ship were deficient.	Water	0-5	inositol polyphosphate-5-phosphatase D	Homo sapiens	39-43
9568898-8	1998	Analysis of the water structure at the catalytic site of the native enzyme, shows that five waters are displaced by ligand binding and that there is a significant decrease in mobility of the remaining waters on formation of the GPb-hydantoin complex.	Water	16-21	glycogen phosphorylase B	Homo sapiens	228-231
9568898-8	1998	Analysis of the water structure at the catalytic site of the native enzyme, shows that five waters are displaced by ligand binding and that there is a significant decrease in mobility of the remaining waters on formation of the GPb-hydantoin complex.	Water	92-98	glycogen phosphorylase B	Homo sapiens	228-231
9568898-8	1998	Analysis of the water structure at the catalytic site of the native enzyme, shows that five waters are displaced by ligand binding and that there is a significant decrease in mobility of the remaining waters on formation of the GPb-hydantoin complex.	Water	201-207	glycogen phosphorylase B	Homo sapiens	228-231
9514766-2	1998	To complement experiment and to obtain more detailed information about the structure and dynamic behavior of the denatured state, we have performed eleven 2.5 ns molecular dynamics simulations of reduced bovine pancreatic trypsin inhibitor (BPTI) at high temperature in water and a control simulation at 298 K, for a total of 30 ns of simulation time.	Water	270-275	spleen trypsin inhibitor I	Bos taurus	241-245
9518571-4	1998	It is assumed that methemoglobin affects the structural and physicochemical parameters of lipid-water interface.	Water	96-101	hemoglobin subunit gamma 2	Homo sapiens	19-32
9530806-3	1998	The system is relatively simple and relies on heated tap water or ice to adjust the temperature.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
9486141-8	1998	Maximum inward current was largest in ClC-2 delta NT-injected oocytes (-5.9 +/- 0.4 microA), followed by ClC-2-injected oocytes (-4.3 +/- 0.6 microA), and smallest in water-injected oocytes (-0.2 +/- 0.2 microA), whereas the order of increase in oocyte diameter was as follows: water-injected oocytes (9.0 +/- 0.2%) &gt; ClC-2-injected oocytes (5.3 +/- 0.5%) &gt; ClC-2 delta NT-injected oocytes (1.1 +/- 0.2%).	Water	278-283	chloride channel protein 2	Oryctolagus cuniculus	38-43
21644759-8	1998	Enthalpy-entropy compensation revealed that the main parameters determining retention in the range of the water fraction (0.2-0.7) increased as follows:  free methanol   solute solvation &gt; methanol/water cluster   solute solvation &gt; RP18 stationary phase   solute interaction.	Water	106-111	pre-mRNA processing factor 3	Homo sapiens	239-243
11819229-4	1998	When the drinking water switched from river and well water to tap water, the gastric cancer incidence decreased to 30.33/10(5) and 26.10/10(5), and the gastric cancer mortality decreased by 59% and 57% respectively.CONCLUSION: The quality of drinking water is one of the important factors of increased incidence of gastric cancer in Changle County, and water quality improvement has a beneficial effect, but the cause of high gastric cancer incidence may be multi-factorial in this area.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	62-65
9514043-3	1998	Most of the people (56%) were drinking some bottled water or filtered tap water and 25% of water intake was away from home.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
9514043-3	1998	Most of the people (56%) were drinking some bottled water or filtered tap water and 25% of water intake was away from home.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
9514044-5	1998	The geometric mean of lead in the random tap water samples was 0.5 microgram/l (95% C.I., 0.5-0.6) and 0.7 microgram/l (95% C.I., 0.6-0.8) in the stagnant tap water samples.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
9548213-1	1998	This review cites new evidence suggesting a link between the recently discovered membrane bound water-selective channel, aquaporin-4 (AQP4), and the mechanism of central osmoreception.	Water	96-101	aquaporin 4	Homo sapiens	121-132
9548213-1	1998	This review cites new evidence suggesting a link between the recently discovered membrane bound water-selective channel, aquaporin-4 (AQP4), and the mechanism of central osmoreception.	Water	96-101	aquaporin 4	Homo sapiens	134-138
9663452-2	1998	administration of glucagon-like peptide-1-(7-37) amide (GLP-1) has been shown to modulate food and water intake.	Water	99-104	glucagon	Rattus norvegicus	18-41
9663452-2	1998	administration of glucagon-like peptide-1-(7-37) amide (GLP-1) has been shown to modulate food and water intake.	Water	99-104	glucagon	Rattus norvegicus	56-61
9786175-1	1998	In vivo, atrial natriuretic peptide (ANP) inhibits water and sodium absorption by the intestine.	Water	51-56	natriuretic peptide A	Rattus norvegicus	9-35
9786175-1	1998	In vivo, atrial natriuretic peptide (ANP) inhibits water and sodium absorption by the intestine.	Water	51-56	natriuretic peptide A	Rattus norvegicus	37-40
9488240-9	1997	CONCLUSIONS: Activation both of A1 and of A2 receptor causes a reduction in urinary water and sodium excretion.	Water	84-89	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	32-53
9448748-4	1997	Elevated human exposure to this element, mostly caused by the intake of contaminated tap water, is associated with increased incidences of cancer at various sites.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
9427293-3	1997	A transgenic mouse lacking water channel AQP4 was used to show that AQP4 is the OAP protein.	Water	27-32	aquaporin 4	Mus musculus	68-72
29735091-2	2018	The present study aims to quantify risks of using tap water in France for the preparation of infant formula, during the first six months of life.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
9502190-5	1998	One minute after starting the lipid perfusion, 15 g of lactulose dissolved in 20 mL of tap water was infused.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
29735091-8	2018	Consuming infant formula rehydrated with un-boiled tap water during the first six months of life led to a total of 2250 DALYs per 100,000 infants (90% uncertainty interval [960; 7650]) for Cryptosporidium due to diarrhea, and 1 DALY [0.4; 2] for arsenic due to expected lifetime risk of lung and bladder cancer as a result of early exposure in life.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
18966962-6	1997	The proposed procedure was applied to determination of chromium (VI) in tap water.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
29735091-12	2018	This multi-risk assessment model could help public health authorities and managers in evaluating both microbiological and chemical safety issues associated with using infant formula prepared with tap water.	Water	200-205	nuclear RNA export factor 1	Homo sapiens	196-199
9421486-13	1998	The results thus indicate that normalization of aortic cGMP and eNOS protein expression in vascular tissue is associated with increased sodium and water excretion in cirrhotic rats with ascites.	Water	147-152	nitric oxide synthase 3	Rattus norvegicus	64-68
29801806-5	2018	As intracellular water content of S. cerevisiae strain 14 (a strain with moderate tolerance to dehydration-rehydration) was reduced to 1.5 g water/g dry weight, the activity of the Agt1 transporter decreased by 10-15 %.	Water	17-22	alpha-glucoside permease	Saccharomyces cerevisiae S288C	181-185
9773526-7	1998	Detection limits were 0.02 and 0.05 mg L-1 in water and urine respectively, with linear calibration curves in the 0.05-10 L-1 concentration range.	Water	46-51	ribosomal protein L4	Rattus norvegicus	39-42
9325187-10	1997	We conclude that AQP4 and AQP5 water channels are expressed on mouse lacrimal gland cells, with greater expression of AQP4 on the basolateral membrane and of AQP5 on the apical membrane.	Water	31-36	aquaporin 5	Mus musculus	26-30
29588495-1	2018	What happens to tap water when you are away from home?	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
9325187-10	1997	We conclude that AQP4 and AQP5 water channels are expressed on mouse lacrimal gland cells, with greater expression of AQP4 on the basolateral membrane and of AQP5 on the apical membrane.	Water	31-36	aquaporin 4	Mus musculus	118-122
9325187-10	1997	We conclude that AQP4 and AQP5 water channels are expressed on mouse lacrimal gland cells, with greater expression of AQP4 on the basolateral membrane and of AQP5 on the apical membrane.	Water	31-36	aquaporin 5	Mus musculus	158-162
9285046-2	1997	These methemoglobin-containing red cell granules were very effective for detecting and absorbing cyanide in water.	Water	108-113	hemoglobin subunit gamma 2	Homo sapiens	6-19
18966990-9	1997	The proposed method was applied to the determination of both analytes in river and tap water and the results were consistent with those provided by the AAS standard method.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
9421280-4	1997	In a rodent model of acute thermal nociception, the mouse tail immersion test, Dex, in wild type (WT) control animals, produced a dose-dependent increase in the threshold for tail withdrawal from a 52 degrees C water bath with mean ED50 values of 99.9+/-14.5 (alpha2A), 94.6+/-17.8 (alpha2B) and 116.0/-17.1 (alpha2C) microg kg(-1), i.p.	Water	211-216	adrenergic receptor, alpha 2c	Mus musculus	309-316
29588495-4	2018	Here, we track tap water microbiome assembly in situ, showing that bacterial community composition changes rapidly from the city supply following ~6-day stagnation, along with an increase in cell count from 103 cells/mL to upwards of 7.8 x 105 cells/mL.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
29497503-12	2018	Factor 2, "soft tissue strain", which is correlated with pain in the neck, shoulders/arms, lower back and hips/pelvis or legs, is marginally negatively associated with currently (-0.18, 95% CI -0.32 to -0.04) carrying water.	Water	218-223	transcription termination factor 2	Homo sapiens	0-8
9416613-1	1997	alpha-Hemolysin from Staphylococcus aureus assembles from a water-soluble, monomeric species to a membrane-bound heptamer on the surface of target cells, creating water-filled channels that lead to cell death and lysis.	Water	60-65	AT695_RS11870	Staphylococcus aureus	0-15
9416613-1	1997	alpha-Hemolysin from Staphylococcus aureus assembles from a water-soluble, monomeric species to a membrane-bound heptamer on the surface of target cells, creating water-filled channels that lead to cell death and lysis.	Water	163-168	AT695_RS11870	Staphylococcus aureus	0-15
9315369-12	1997	Simultaneous infusion of indomethacin with EGF attenuated (P &lt; 0.05) the stimulatory effects of EGF infusion alone on urine volume, water intake, natriuresis and urine osmolality.	Water	135-140	EGF	Ovis aries	43-46
29277540-6	2018	This critical role in water barrier function was confirmed in Cldn3-/- and Cldn3+/- mice and those with experimentally decreased claudin-3.	Water	22-27	claudin 3	Mus musculus	62-67
10177207-7	1997	All 3 organisms pose a challenge to the water industry, as they are difficult to detect in water when small numbers of cysts or oocysts are present.	Water	40-45	paired box 5	Homo sapiens	0-5
10177207-7	1997	All 3 organisms pose a challenge to the water industry, as they are difficult to detect in water when small numbers of cysts or oocysts are present.	Water	91-96	paired box 5	Homo sapiens	0-5
9408995-0	1997	Liquid chromatography-atmospheric pressure ionization mass spectrometry for the determination of chloro- and nitrophenolic compounds in tap water and sea water.	Water	140-145	nuclear RNA export factor 1	Homo sapiens	136-139
9431267-0	1997	Reduced skin hyperemia during tap water iontophoresis after intake of acetylsalicylic acid.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
9431267-1	1997	Skin microcirculation and skin temperature of 10 healthy subjects (6 men and 4 women, 20-44 yr of age) without any vascular diseases were registered when a thermoindifferent tap water iontophoresis was applied.	Water	178-183	nuclear RNA export factor 1	Homo sapiens	174-177
9431267-7	1997	After ending tap water iontophoresis, the skin temperature increased more on the cathode side than on the anode side (P &lt; 0.001).	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
9310074-1	1997	Atrial natriuretic peptide (ANP) is a hormone important in the cardiovascular system via its regulatory roles in sodium and water excretion, and in vasodilatation.	Water	124-129	natriuretic peptide A	Rattus norvegicus	0-26
9310074-1	1997	Atrial natriuretic peptide (ANP) is a hormone important in the cardiovascular system via its regulatory roles in sodium and water excretion, and in vasodilatation.	Water	124-129	natriuretic peptide A	Rattus norvegicus	28-31
29277540-6	2018	This critical role in water barrier function was confirmed in Cldn3-/- and Cldn3+/- mice and those with experimentally decreased claudin-3.	Water	22-27	claudin 3	Mus musculus	75-80
9460351-0	1997	Endoscopy water source: tap or sterile water?	Water	10-15	nuclear RNA export factor 1	Homo sapiens	24-27
29277540-6	2018	This critical role in water barrier function was confirmed in Cldn3-/- and Cldn3+/- mice and those with experimentally decreased claudin-3.	Water	22-27	claudin 3	Mus musculus	129-138
9460351-6	1997	Many of the tap water samples were positive for normal flora found in city water sources.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
9460351-8	1997	The use of tap water and clean water bottles was found to carry no greater risk than using sterile water and sterile bottles.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
29952326-4	2018	Most respondents reported that they believe their drinking water is of high quality, with 81.4% responding that they believe their tap water is safe to drink.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	131-134
29952326-5	2018	An even larger number, 92.1%, of those receiving their water from private sources believe their tap water is safe.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	96-99
15344248-1	1997	I"ve always used tap water for drinking and cooking, but I wonder if it"s safe.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
29952326-5	2018	An even larger number, 92.1%, of those receiving their water from private sources believe their tap water is safe.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
9277550-10	1997	It is concluded that 1) endogenous downregulation of components of the renin-angiotensin-aldosterone system is a pivotal compensatory mechanism to reduce Na and water retention and 2) natriuretic and diuretic factors seem to be of minor potency, because not even the sum of all could counterbalances the Na- and water-retaining effects of Aldo and ANG II.	Water	161-166	renin	Canis lupus familiaris	71-76
29952326-6	2018	Conversely, only 57.0% of respondents who consume bottled water as their primary source of drinking water believe their tap water is safe to drink.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	120-123
9277550-10	1997	It is concluded that 1) endogenous downregulation of components of the renin-angiotensin-aldosterone system is a pivotal compensatory mechanism to reduce Na and water retention and 2) natriuretic and diuretic factors seem to be of minor potency, because not even the sum of all could counterbalances the Na- and water-retaining effects of Aldo and ANG II.	Water	312-317	renin	Canis lupus familiaris	71-76
29952326-6	2018	Conversely, only 57.0% of respondents who consume bottled water as their primary source of drinking water believe their tap water is safe to drink.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	120-123
9402049-1	1997	We have characterized the action of the novel, water-soluble, tachykinin NK2 receptor antagonist MEN 11420 ([Asn(2-AcNH-beta-D-Glc)-Asp-Trp-Phe-Dap-Leu] c(2 beta-5 beta)) on the circular muscle of the guinea-pig and human colon in vitro and on the guinea-pig colon in vivo.	Water	47-52	tachykinin receptor 2	Homo sapiens	73-76
29952326-6	2018	Conversely, only 57.0% of respondents who consume bottled water as their primary source of drinking water believe their tap water is safe to drink.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	120-123
29904379-1	2018	The identification of activated T-lymphocytes restricted to myelin-derived immunogenic peptides in multiple sclerosis (MS) and aquaporin-4 water channel in neuromyelitis optica (NMO) in the blood of patients opened the possibility for developing highly selective and disease-specific therapeutic approaches.	Water	139-144	aquaporin 4	Homo sapiens	127-138
9396229-7	1997	The proliferation response of lymph node cells from TGF-beta 1 injected mice with IRBP-induced EAU was suppressed compared with phosphate buffered saline (PBS)-injected mice.	Water	95-98	retinol binding protein 3, interstitial	Mus musculus	82-86
9268639-1	1997	Uroguanylin, a member of the guanylin peptide family, is a novel peptide regulator in intestinal salt and water transport.	Water	106-111	guanylate cyclase activator 2B	Homo sapiens	0-11
29733189-8	2018	(iii) However, and in contrast to the behavior observed in GQD solutions, the fluorescence of the composite remains unaltered over a wide pH range and in the presence of different ions commonly found in tap water.	Water	207-212	nuclear RNA export factor 1	Homo sapiens	203-206
9178866-10	1997	wt Fos-related antigens in apomorphine-primed rats treated with water or quinpirole.	Water	64-69	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	3-6
9386008-3	1997	To induce the expression of Fos protein, two kinds of stimuli and experimental controls were performed in chloralose/urethane-anesthetized animals: (i) electrical stimulation of the trigeminal ethmoidal nerve (EN5) and, as sham controls, dissection of the EN5 without electrical stimulation, (ii) stimulation of the nasal mucosa with water and, as control experiments, no stimulation.	Water	334-339	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	28-31
9386008-5	1997	Differences could be observed rostrally in the PBL and KF, where significantly higher numbers of Fos-positive neurons were present after EN5 versus water stimulation.	Water	148-153	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-100
9386008-8	1997	In the water-stimulated rats compared with the anesthesia controls, a significantly higher number of Fos-immunoreactive neurons was always observed at all rostrocaudal levels in the KF and in the midlevel PBL.	Water	7-12	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	101-104
9386008-10	1997	In contrast, after water stimulation Fos-positive neurons were exclusively found in the Sp5C.	Water	19-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-40
9224700-1	1997	Water-soluble amyloid beta-peptides (sA beta), ending at residue 42, precede amyloid plaques in Down"s syndrome (DS).	Water	0-5	serum amyloid A1 cluster	Homo sapiens	37-44
29474900-3	2018	AIM OF THE STUDY: This study aims to observe the attenuation of the water extract of Forsythiae Fructus (FSE) on carbon tetrachloride (CCl4)-induced hepatic fibrosis in male C57BL/6 mice.	Water	68-73	chemokine (C-C motif) ligand 4	Mus musculus	135-139
9218704-0	1997	Guanylin-, heat-stable enterotoxin of Escherichia coli- and vasoactive intestinal peptide-induced water and ion secretion in the rat intestine in vivo.	Water	98-103	guanylate cyclase activator 2A	Rattus norvegicus	0-8
9322224-1	1997	In the initial experiments reviewed here, we show that atrial natriuretic peptide (ANP) plays an important inhibitory role in the control of sodium chloride and water intake since injections of ANP into the third ventricle (3V) caused a reduction in dehydration-induced drinking and also the drinking of salt in salt-depleted rats.	Water	161-166	natriuretic peptide A	Rattus norvegicus	55-81
9322224-1	1997	In the initial experiments reviewed here, we show that atrial natriuretic peptide (ANP) plays an important inhibitory role in the control of sodium chloride and water intake since injections of ANP into the third ventricle (3V) caused a reduction in dehydration-induced drinking and also the drinking of salt in salt-depleted rats.	Water	161-166	natriuretic peptide A	Rattus norvegicus	83-86
9322224-14	1997	This is further accomplished by reduction in intake of water and salt mediated also by brain ANP.	Water	55-60	natriuretic peptide A	Rattus norvegicus	93-96
9218704-7	1997	Guanylin induced less water and ion secretion than that produced by heat-stable enterotoxin in the colon, confirming the results of in vitro studies, and also in duodenum and ileum.	Water	22-27	guanylate cyclase activator 2A	Rattus norvegicus	0-8
29774656-5	2018	The accuracy and the applicability of the developed method was checked in tap water and two different wastewater samples by spiked recovery tests.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
9299743-5	1997	The ensuing method was applied to river and tap water with good repeatability and reproducibility, and no interference from the sample matrix.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
29667813-0	2018	A Sensitive Water-Soluble Reversible Optical Probe for Hg2+ Detection.	Water	12-17	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	55-58
9228019-1	1997	The binding site of the beta2 adrenergic receptor, like that of other homologous G-protein-coupled receptors, is contained within a water-accessible crevice formed among its seven membrane-spanning segments.	Water	132-137	adrenoceptor beta 2	Homo sapiens	24-49
9215537-8	1997	The free energies of unfolding (delta G(H2O)) of rLCAT and pLCAT are 3.4 +/- 0.2 and 3.2 +/- 0.2 kcal/mol, respectively, as determined by guanidine hydrochloride denaturation monitored by fluorescence.	Water	40-43	lecithin cholesterol acyltransferase	Rattus norvegicus	49-54
9215537-9	1997	These relatively low delta G(H2O) values support the notion that LCAT is capable of undergoing major conformational changes upon interaction with interfacial substrates.	Water	29-32	lecithin-cholesterol acyltransferase	Homo sapiens	65-69
9230060-2	1997	The spin-1/2-carrying NO molecule interacts with both the S1 and S2 states of the water oxidizing complex.	Water	82-87	spindlin 1	Homo sapiens	4-10
29667813-5	2018	The resultant molecule qHCM afforded a distinct reversible change in the absorption features and a concomitant visible color change upon binding to Hg2+ ions, leading to a highly water-soluble mercury sensor with a 10 ppb detection limit.	Water	179-184	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	148-151
29667813-8	2018	High selectivity and sensitivity toward Hg2+ detection make qHCM an attractive probe for detecting Hg2+ in contaminated water sources, which is a major environmental toxicity concern.	Water	120-125	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	40-43
9143504-1	1997	Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis.	Water	27-32	aquaporin 4	Homo sapiens	0-11
29667813-8	2018	High selectivity and sensitivity toward Hg2+ detection make qHCM an attractive probe for detecting Hg2+ in contaminated water sources, which is a major environmental toxicity concern.	Water	120-125	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	99-102
29486838-5	2018	Unlike the CF-board, the fabricated CNF-board had a high water-activated dimensional recovery ratio (averagely 96%) during the five cyclic wetting-drying process.	Water	57-62	NPHS1 adhesion molecule, nephrin	Homo sapiens	36-39
9083275-6	1997	Our results indicate that renal ANP mRNA expression is enhanced in diabetic rats, and that renal-synthesized ANP as one of regulators to handle water and sodium balance in diabetic rats is worthy of further investigation.	Water	144-149	natriuretic peptide A	Rattus norvegicus	109-112
9240424-1	1997	Changes in gastric mucosal constitutive NO synthase (cNOS) and inducible NO synthase (iNOS) activities with the development of gastric mucosal lesions induced by water immersion restraint (WIR) stress were investigated in rats pretreated with and without NOS inhibitors.	Water	162-167	nitric oxide synthase 3	Rattus norvegicus	53-57
9218437-10	1997	For both the serine and matrix metalloproteinases, catalysis of peptide bond cleavage in insoluble elastin was characterized by temperature effects and water requirements typical of common enzyme-catalyzed reactions, even those involving soluble substrates.	Water	152-157	elastin	Homo sapiens	99-106
29756589-8	2018	RESULTS: Compared with saline-treated controls, the combination therapy of VEGF and NGF significantly reduced infarct volume, water content, neural cell apoptosis and the expression of caspase-3, up-regulated the expression of Bcl-2 and improved functional recovery (both p&lt;0.01) when administered 5 or 8 hours after ischemia.	Water	126-131	vascular endothelial growth factor A	Oryctolagus cuniculus	75-79
9219689-5	1997	If it is composed of H2O, the principal ion is H3O+ and the neutral temperature is about 340 kelvin.	Water	21-24	H3 clustered histone 15	Homo sapiens	47-50
18966793-8	1997	Calibration and the standard addition methods are discussed and demonstrated by determining copper in tap water as a method of testing the procedure.	Water	106-111	nuclear RNA export factor 1	Homo sapiens	102-105
29684671-4	2018	Our results also indicate the heterogeneities in the improving effects of clean water with respect to the coverage of tap water among citizens.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	118-121
9138683-19	1997	These results suggest that the central NK3 receptor, probably located in the hypothalamus, is implicated in the renal control of water and electrolyte homeostasis through the release of vasopressin in the conscious saline-loaded rat.	Water	129-134	tachykinin receptor 3	Rattus norvegicus	39-51
9195910-9	1997	These results indicate very different intrinsic water permeabilities for the mammalian aquaporin homologs, with the pf value for AQP4 remarkably higher than those for the others.	Water	48-53	aquaporin 4	Homo sapiens	129-133
29684671-6	2018	However, the subsequent expansion of tap water could result in a continuous decline in the overall risk of deaths in the second phase.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
9223600-6	1997	These findings suggest that CNP inhibits the basal secretion of AVP through natriuretic peptide receptor (NPR)-B and has a role in the body water and electrolyte homeostasis in the central nervous system.	Water	140-145	natriuretic peptide C	Rattus norvegicus	28-31
29519719-6	2018	He was given 0.4 mg nitroglycerin dissolved in 10 mL tap water orally, and obtained complete relief of symptoms within 2 min.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
9041246-9	1997	At pHi &lt;6.5, swelling occurs through excess osmolyte (and consequently water) uptake via a bumetanide-sensitive NaK2Cl cotransporter.	Water	74-79	glucose-6-phosphate isomerase	Oryctolagus cuniculus	3-6
9196382-1	1997	The antioxidant activities of compounds endogenous to bovine rod outer segments (ROS) were investigated by measuring the loss of polyunsaturated fatty acids (PUFA"s) from membranes exposed to the water-soluble oxidant 2,2"-azobis(2-amidinopropane) dihydrochloride (AAPH).	Water	196-201	PUFA	Bos taurus	158-162
29900322-0	2018	Human health risk assessment data of trace elements concentration in tap water-Abeokuta South, Nigeria.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
29900322-3	2018	In this study, the concentration of fluoride in tap water varied at different locations, ranging from 0.48 mg/L to 1.84 mg/L with an average value of 1.23 mg/L while that of iron ranged from 0.02 to 2.96 mg/L.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
9044391-1	1997	Central administration of the preproglucagon-derived peptide glucagon-like peptide-1 significantly inhibits ingestion of food and water, and glucagon-like peptide-1 binding sites are present in a multitude of central areas involved in the regulation of ingestional behaviour.	Water	130-135	glucagon	Rattus norvegicus	61-84
32254434-5	2018	ANS-based fluorescence spectroscopy indicated that the critical micelle concentration (CMC) for C1 was 18.5 muM in water.	Water	115-120	prefoldin subunit 4	Homo sapiens	96-98
29641556-4	2018	Of the tap water samples analyzed, 81% were found to contain anthropogenic particles.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
9094750-1	1997	Somatostatin modulates important physiologic functions of the kidney, including mesangial cell contraction, glomerular prostaglandin synthesis, and phosphate, water and sodium excretion.	Water	159-164	somatostatin	Homo sapiens	0-12
9094754-1	1997	Guanylin, a peptide purified from rat jejunum, is thought to regulate water and electrolyte balance in the intestine.	Water	70-75	guanylate cyclase activator 2A	Rattus norvegicus	0-8
29641556-10	2018	Based on consumer guidelines, our results indicate the average person ingests over 5,800 particles of synthetic debris from these three sources annually, with the largest contribution coming from tap water (88%).	Water	200-205	nuclear RNA export factor 1	Homo sapiens	196-199
29206474-0	2018	Trace lithium in Texas tap water is negatively associated with all-cause mortality and premature death.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
8995215-1	1997	Pancreatic lipase is characterized by increased activity against water-insoluble substrates and by dependence on another protein, colipase, for binding to the substrate interface.	Water	65-70	pancreatic lipase	Homo sapiens	0-17
29206474-2	2018	Using a larger dataset with several Texas counties, our study shows that lithium concentrations in tap water are negatively associated with all-cause mortality (r = -0.18, p = 0.006, 232 counties) and years of potential life lost (r = -0.22, p = 0.001, 214 counties).	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
9059546-15	1997	Study 6: Water for injection caused marked up-regulation of CD1 1b and down-regulation of L-selectin.	Water	9-14	integrin subunit alpha M	Homo sapiens	60-66
31938330-0	2018	miR-190 protects cardiomyocytes from apoptosis induced by H2O2 through targeting MAPK8 and regulating MAPK8/ERK signal pathway.	Water	58-62	microRNA 190	Rattus norvegicus	0-7
9407174-16	1997	CONCLUSION: Each cleansing agent, even normal tap water, influences the skin surface.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
31938330-4	2018	Here, we determined the expression level of miR-190 in H9c2 cells under H2O2 treatment and found that miR-190 expression was significantly inhibited by H2O2.	Water	72-76	microRNA 190	Rattus norvegicus	44-51
31938330-4	2018	Here, we determined the expression level of miR-190 in H9c2 cells under H2O2 treatment and found that miR-190 expression was significantly inhibited by H2O2.	Water	72-76	microRNA 190	Rattus norvegicus	102-109
31938330-4	2018	Here, we determined the expression level of miR-190 in H9c2 cells under H2O2 treatment and found that miR-190 expression was significantly inhibited by H2O2.	Water	152-156	microRNA 190	Rattus norvegicus	44-51
15093378-0	1997	Removal of TNT and RDX from water and soil using iron metal.	Water	28-33	radixin	Homo sapiens	19-22
31938330-4	2018	Here, we determined the expression level of miR-190 in H9c2 cells under H2O2 treatment and found that miR-190 expression was significantly inhibited by H2O2.	Water	152-156	microRNA 190	Rattus norvegicus	102-109
31938330-5	2018	Further study indicated that miR-190 significantly reduced cell apoptosisand the LDH and MDA levels of H9c2 cells induced by H2O2.	Water	125-129	microRNA 190	Rattus norvegicus	29-36
31938330-9	2018	In conclusion, these data suggest that miR-190 protects against oxidative stress injury of H9c2 cells induced by H2O2 through inhibiting MAPK8 expression and the MAPK8/ERK pathway.	Water	113-117	microRNA 190	Rattus norvegicus	39-46
9392839-13	1997	The ANP released would also act on the kidneys to cause natriuresis and ANP acts within the brain to inhibit water and salt intake leading to a gradual recovery of circulating blood volume to normal.	Water	109-114	natriuretic peptide A	Rattus norvegicus	4-7
9392839-13	1997	The ANP released would also act on the kidneys to cause natriuresis and ANP acts within the brain to inhibit water and salt intake leading to a gradual recovery of circulating blood volume to normal.	Water	109-114	natriuretic peptide A	Rattus norvegicus	72-75
28427307-3	2018	The total binding enthalpy energies have been obtained by MM-PBSA thermodynamic computations and the favorability of p32.LyP-1 complex in water has been shown by explicit water MD computations.	Water	138-143	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	121-126
28427307-3	2018	The total binding enthalpy energies have been obtained by MM-PBSA thermodynamic computations and the favorability of p32.LyP-1 complex in water has been shown by explicit water MD computations.	Water	171-176	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	121-126
8973169-11	1996	On the basis of a computer-assisted molecular modeling analysis, it was determined that addition of a hydroxyl to the naphthyl 4-position, giving [1, 1-difluoro-1-[2-(4-hydroxynaphthalenyl)] methyl]phosphonic acid (8), could potentially replace a water molecule situated in the PTP1B-6 complex, thereby allowing new hydrogen-bonding interactions with Lys 120 and Tyr 46.	Water	247-252	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	278-283
29388499-5	2018	The results of osmolarity and spin-lattice relaxation time (T1) of water measurements in the presence of PGDs suggest that increased amounts of bound water to PGD molecules trigger aggregation along with the direct interaction with ADH.	Water	67-72	aldo-keto reductase family 1 member A1	Homo sapiens	232-235
8986218-8	1996	After chronic ETOH administration, total ANP content and concentration were higher in the left and right atria of SHR and WKY rats than in water-treated controls.	Water	139-144	natriuretic peptide A	Rattus norvegicus	41-44
29388499-5	2018	The results of osmolarity and spin-lattice relaxation time (T1) of water measurements in the presence of PGDs suggest that increased amounts of bound water to PGD molecules trigger aggregation along with the direct interaction with ADH.	Water	150-155	aldo-keto reductase family 1 member A1	Homo sapiens	232-235
29367277-5	2018	Our data show that all three GlyT1 blockers reduce relapse-like alcohol consumption and cause either minimal or no side effects, measured as changes in home-cage activity, water intake, and body weight.	Water	172-177	solute carrier family 6 member 9	Rattus norvegicus	29-34
8931474-3	1996	With this aim poly(lactide-co-glycolide) microspheres loaded with a highly potent, peptidase-resistant, cholecystokinin (CCK)-B-selective CCK peptidomimetic agonist (pBC 264) were prepared by a water in oil in water emulsion solvent evaporation method and stereotaxically implanted into the anterior part of the rat nucleus accumbens.	Water	194-199	cholecystokinin	Rattus norvegicus	138-141
29565042-2	2018	Here we adopted integrative translational and reverse-translational approaches to explore the role of an astrocyte-specific major water channel in the brain, aquaporin-4 (AQP4), in brain plasticity and learning.	Water	130-135	aquaporin 4	Homo sapiens	158-169
8931474-3	1996	With this aim poly(lactide-co-glycolide) microspheres loaded with a highly potent, peptidase-resistant, cholecystokinin (CCK)-B-selective CCK peptidomimetic agonist (pBC 264) were prepared by a water in oil in water emulsion solvent evaporation method and stereotaxically implanted into the anterior part of the rat nucleus accumbens.	Water	210-215	cholecystokinin	Rattus norvegicus	138-141
8863504-17	1996	dose of a GLP-1 receptor antagonist [exendin (9-39); 2,500 ng] reversed the inhibitory effects of GLP-1 (7-36) amide (1,000 ng dose) and exendin-4 (25 ng dose) on food and water ingestion.	Water	172-177	glucagon-like peptide 1 receptor	Rattus norvegicus	10-24
8863504-17	1996	dose of a GLP-1 receptor antagonist [exendin (9-39); 2,500 ng] reversed the inhibitory effects of GLP-1 (7-36) amide (1,000 ng dose) and exendin-4 (25 ng dose) on food and water ingestion.	Water	172-177	glucagon	Rattus norvegicus	10-15
29565042-2	2018	Here we adopted integrative translational and reverse-translational approaches to explore the role of an astrocyte-specific major water channel in the brain, aquaporin-4 (AQP4), in brain plasticity and learning.	Water	130-135	aquaporin 4	Homo sapiens	171-175
29722329-4	2018	Western blot assay results showed that the expression of heme oxygenase-1 (HO-1), the key component of the cholinergic anti-inflammatory pathway, in the right striatum of rat models of Huntington"s disease subjected to intraperitoneal injection of PHA 543613 for 4 days was significantly increased compared to the control rats receiving intraperitoneal injection of sterile water, and that the increase in HO-1 expression was independent of change in alpha7nAChR expression.	Water	374-379	heme oxygenase 1	Rattus norvegicus	57-73
29722329-4	2018	Western blot assay results showed that the expression of heme oxygenase-1 (HO-1), the key component of the cholinergic anti-inflammatory pathway, in the right striatum of rat models of Huntington"s disease subjected to intraperitoneal injection of PHA 543613 for 4 days was significantly increased compared to the control rats receiving intraperitoneal injection of sterile water, and that the increase in HO-1 expression was independent of change in alpha7nAChR expression.	Water	374-379	heme oxygenase 1	Rattus norvegicus	75-79
29424463-1	2018	We have previously reported that the dispersion of spin-lattice relaxation rates in the rotating frame (R1rho ) of tissue water protons at high field can be dominated by chemical exchange contributions.	Water	122-127	spindlin 1	Rattus norvegicus	51-55
8898007-1	1996	To investigate the role of renal synthesis of atrial natriuretic peptide (ANP) as a contributor to the water-sodium homeostasis, we studied the effects of electrolyte-water imbalance on renal ANP mRNA levels, plasma ANP concentrations, and urinary ANP excretion rates by using reverse transcription-polymerase chain reaction (PCR) and radioimmunoassay.	Water	103-108	natriuretic peptide A	Rattus norvegicus	46-72
8898007-1	1996	To investigate the role of renal synthesis of atrial natriuretic peptide (ANP) as a contributor to the water-sodium homeostasis, we studied the effects of electrolyte-water imbalance on renal ANP mRNA levels, plasma ANP concentrations, and urinary ANP excretion rates by using reverse transcription-polymerase chain reaction (PCR) and radioimmunoassay.	Water	103-108	natriuretic peptide A	Rattus norvegicus	74-77
29332797-10	2018	The method was successively applied to determine the concentrations of trace amounts of chloroacetic acids in tap water.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	110-113
9148646-5	1996	The proposed method was successfully applied to the determination of copper(II) in tap water and biological material.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
29332797-12	2018	However, enrichment with the present method is effective for determination of tap water quality by improving the limits of detection of HPLC-UV.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
8904639-7	1996	), an antagonist with reported selectivity for the alpha 2b-adrenoceptor subtype, the increase in free water but not osmolar clearance was decreased.	Water	103-108	adrenoceptor alpha 2B	Rattus norvegicus	51-72
29332797-13	2018	The standard addition test with real tap water samples shows good recoveries (94.9-109.6%).	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
29488376-10	2018	The losses are related to the amount of absorbed water in the HTL, inducing loss of active area in terms of interfacial contact.	Water	49-54	Leucine transport, high	Homo sapiens	62-65
8855281-1	1996	The aquaporin family of membrane water transport proteins are expressed in diverse tissues, and in brain the predominant water channel protein is AQP4.	Water	33-38	aquaporin 4	Homo sapiens	146-150
8855281-1	1996	The aquaporin family of membrane water transport proteins are expressed in diverse tissues, and in brain the predominant water channel protein is AQP4.	Water	121-126	aquaporin 4	Homo sapiens	146-150
9224803-2	1997	Water deprivation for 48 h caused a significant increase in the number of Ucn-IR neurons in the SON, compared with control.	Water	0-5	urocortin	Rattus norvegicus	74-77
29546256-1	2018	In this study, we synthesize a novel oleic acid-based gemini surfactant with carboxylate headgroups, and study the effect of stereochemistry (anti- vs. syn-) on self-aggregation properties in water.	Water	192-197	synemin	Homo sapiens	18-21
9177195-4	1997	When shifted to a low-osmotic-strength buffer, cells expressing rd28 swelled rapidly and burst, indicating that the plant aquaporin allowed rapid water entry in the amoebae.	Water	146-151	Aquaporin-like superfamily protein	Arabidopsis thaliana	64-68
8897595-2	1996	Although similar to the IL-10 structure determined previously at room temperature, this low-temperature IL-10 structure contains, in addition, four N-terminal residues, three sulfate anions, and 175 extra water molecules.	Water	205-210	interleukin 10	Homo sapiens	104-109
29546256-6	2018	We propose that, for the syn form gemini surfactant, the closer packing of the headgroups as well as the hydrogen bonding network around the micelle interface prevent water penetration into the hydrophobic part of the micelle.	Water	167-172	synemin	Homo sapiens	25-28
29350629-2	2018	The nAg were synthesized, dispersed in deionized (DI) water and casted onto a pure PPS film, resulting in a conductive film upon the evaporation of DI water and thermal post-annealing.	Water	151-156	NBAS subunit of NRZ tethering complex	Homo sapiens	4-7
9387776-7	1996	The results indicate that ANP in anteroventral region of the third ventricle (AV3V) might play important role in the regulation of water and electolytes.	Water	131-136	natriuretic peptide A	Rattus norvegicus	26-29
9195344-1	1997	Nanosecond scale molecular dynamics simulations in water demonstrate that the DNA oligomer, GCGTATATAAAACGC, which contains a target site for the TATA-box binding protein (TBP), has an intrinsic preference to adopt an A-like conformation in the region of the TATA-box and undergoes bending related to that seen within in the TBP complex.	Water	51-56	TATA-box binding protein	Homo sapiens	146-170
9195344-1	1997	Nanosecond scale molecular dynamics simulations in water demonstrate that the DNA oligomer, GCGTATATAAAACGC, which contains a target site for the TATA-box binding protein (TBP), has an intrinsic preference to adopt an A-like conformation in the region of the TATA-box and undergoes bending related to that seen within in the TBP complex.	Water	51-56	TATA-box binding protein	Homo sapiens	172-175
9195344-1	1997	Nanosecond scale molecular dynamics simulations in water demonstrate that the DNA oligomer, GCGTATATAAAACGC, which contains a target site for the TATA-box binding protein (TBP), has an intrinsic preference to adopt an A-like conformation in the region of the TATA-box and undergoes bending related to that seen within in the TBP complex.	Water	51-56	TATA-box binding protein	Homo sapiens	325-328
9210615-12	1997	The NHE-3 isoform of the Na+/H+ exchanger is likely to be involved in water and electrolyte absorption from bile.	Water	70-75	solute carrier family 9 member A3	Homo sapiens	4-9
8772729-9	1996	Glycerol phosphate shuttle flux, as estimated by [2-3H]glycerol conversion to [3H]H2O, was increased to 120-130% by infection with Adex1CAmGPDH, but not with Adex1CAcGPDH infection, in both MIN6 and HIT cells.	Water	82-85	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	131-143
29470061-5	2018	Tap water samples collected across Fort Collins, CO, were tested with this method and validated against ICP-MS. We demonstrate the ability to quantify the copper content of tap water within 30% of a reference technique at levels ranging from 20 to 500 000 ppb.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
8865183-1	1996	The present studies were designed to test the learning and memory capacities of transgenic mice with central overexpression of corticotropin-releasing factor in a forced alternation water T-maze task and in the Morris water maze.	Water	182-187	corticotropin releasing hormone	Mus musculus	127-157
9148905-0	1997	Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membrane.	Water	26-31	secretin	Rattus norvegicus	0-8
9148905-4	1997	In this study, we tested the hypothesis that secretin promotes osmotic water movement in cholangiocytes by inducing the exocytic insertion of AQP1 into plasma membranes.	Water	71-76	secretin	Rattus norvegicus	45-53
9148905-5	1997	Exposure of highly purified isolated rat cholangiocytes to secretin caused significant, dose-dependent increases in osmotic membrane water permeability (Pf) (e.g. increased by 60% with 10(-7) M secretin), which was reversibly inhibited by the water channel blocker HgCl2.	Water	133-138	secretin	Rattus norvegicus	59-67
9148905-6	1997	Immunoblotting analysis of cholangiocyte membrane fractions showed that secretin caused up to a 3-fold increase in the amount of AQP1 in plasma membranes and a proportional decrease in the amount of the water channel in microsomes, suggesting a secretin-induced redistribution of AQP1 from intracellular to plasma membranes.	Water	203-208	secretin	Rattus norvegicus	72-80
29420013-2	2018	The objective of the present study is to investigate the swelling behavior and accompanying free volume of self-standing TEMPO-oxidized (TO) CNF films in the presence of water vapor.	Water	170-175	NPHS1 adhesion molecule, nephrin	Homo sapiens	141-144
8706020-7	1996	Inhibition of the beta-glucuronidase activity in the intestinal microflora by antibiotics (1 mg penicillin and 2 mg streptomycin per ml of drinking water) markedly ameliorated the diarrhea and reduced cecal damage.	Water	148-153	glucuronidase, beta	Rattus norvegicus	18-36
29405712-1	2018	Here, we investigated the oscillatory motion of a camphor boat on water to clarify how the dynamics of camphor concentration profile determines the period of oscillation.	Water	66-71	ataxin 1 like	Homo sapiens	58-62
8914865-0	1996	Involvement of supraspinal and spinal CCK receptors in the modulation of antinociception induced by cold water swimming stress in the mouse.	Water	105-110	cholecystokinin	Mus musculus	38-41
29511193-4	2018	Here, we hypothesize that Photosystem II Subunit S (PsbS) expression affects a chloroplast-derived signal for stomatal opening in response to light, which can be used to improve water-use efficiency.	Water	178-183	photosystem II 22 kDa protein, chloroplastic	Nicotiana tabacum	26-50
8865340-1	1996	We have performed a 800 ps molecular dynamics simulation of bovine pancreatic trypsin inhibitor (BPTI) in water coupled to a pressure bath at 1, 10,000, 15,000, and 20,000 bar.	Water	106-111	spleen trypsin inhibitor I	Bos taurus	60-95
8865340-1	1996	We have performed a 800 ps molecular dynamics simulation of bovine pancreatic trypsin inhibitor (BPTI) in water coupled to a pressure bath at 1, 10,000, 15,000, and 20,000 bar.	Water	106-111	spleen trypsin inhibitor I	Bos taurus	97-101
29511193-4	2018	Here, we hypothesize that Photosystem II Subunit S (PsbS) expression affects a chloroplast-derived signal for stomatal opening in response to light, which can be used to improve water-use efficiency.	Water	178-183	photosystem II 22 kDa protein, chloroplastic	Nicotiana tabacum	52-56
29991858-7	2018	Results: Tooth Mousse showed statistically significant difference (p-value 0.001) compared with sodium fluoride, artificial saliva, and tap water when stored in both 12 and 24 hours" duration.	Water	140-145	nuclear RNA export factor 1	Homo sapiens	136-139
8713101-1	1996	Guanylin (GCAP-I, guanylate cyclase activating peptide I) and uroguanylin (GCAP-II, guanylate cyclase activating peptide II) are regulatory peptides involved in the regulation of the intestinal chloride / water balance.	Water	205-210	guanylate cyclase activator 2B	Homo sapiens	18-73
8713101-1	1996	Guanylin (GCAP-I, guanylate cyclase activating peptide I) and uroguanylin (GCAP-II, guanylate cyclase activating peptide II) are regulatory peptides involved in the regulation of the intestinal chloride / water balance.	Water	205-210	guanylate cyclase activator 2B	Homo sapiens	75-82
29991858-8	2018	Conclusion: Tooth Mousse was a better storage media when compared with sodium fluoride, artificial saliva, and tap water.	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
29153303-1	2018	BACKGROUND: Aquaporin 4 (AQP4) is a water-selective transport protein expressed in astrocytes throughout the central nervous system.	Water	36-41	aquaporin 4	Mus musculus	12-23
8663387-7	1996	The three-dimensional structures of beta3 and beta1 are virtually identical, with the exception that Cys-369 and two water molecules in beta3 occupy the position of Arg-369 in beta1.	Water	117-122	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	46-51
15299640-7	1996	Results for the co-crystallized T(4) complex show that T(4) binds deep in the hormone-binding channel and displaces the bound water previously reported for T(4) soaked into a native transthyretin crystal [Blake &amp; Oatley (1977).	Water	126-131	transthyretin	Homo sapiens	182-195
29153303-1	2018	BACKGROUND: Aquaporin 4 (AQP4) is a water-selective transport protein expressed in astrocytes throughout the central nervous system.	Water	36-41	aquaporin 4	Mus musculus	25-29
29595154-4	2018	The FO membrane fouling layer mainly consisted of organic substances like polysaccharides and proteins, and was very loose and could be effectively removed by rinsing the membrane surface with tap water.	Water	197-202	nuclear RNA export factor 1	Homo sapiens	193-196
9027233-5	1996	In addition, tests of the peakwise algorithms were made using a set of liquid water samples with delta D Tap Water over the range of 39-407/1000 with uncorrected data with precisions of SD-(delta D Tap Water &lt; 34/1000 and accuracy within 11/1000.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	105-108
29431837-2	2018	We report an in-depth ab initio molecular dynamics (AIMD) study of the spin-state dependence of the structural and vibrational properties of the prototypical [Fe(bpy)3]2+ (bpy = 2,2"-bipyridine) LS complex in water.	Water	209-214	spindlin 1	Homo sapiens	71-75
21619304-5	1996	The detection limit (S/N = 2) and linear range for a 1 L water sample are 2 mug of C L(-)(1) and 10-2500 mug of C L(-)(1), respectively, and they can be adjusted using samples ranging from 100 mL to 2 L. Good repeatablity (RSD less than 10%) and close to 100% recoveries were obtained for KHP added to real samples such as deionized, mineral, tap, and river water and seawater.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	343-346
29100161-0	2018	Hot water-repellent and mechanically durable superhydrophobic mesh for oil/water separation.	Water	4-9	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
8686077-3	1996	The cause was exogenous deposition of copper from domestic tap water which contained an increased copper concentration.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
8793116-8	1996	In ADX animals given corticosterone in their drinking water, V1aR mRNA levels detected by in situ hybridization increased significantly over the ADX rats given saline.	Water	54-59	arginine vasopressin receptor 1A	Rattus norvegicus	61-65
29100161-4	2018	In this study, a hot water-repellent superhydrophobic mesh used for oil/water separation was prepared with one-step spray of modified polyurethane and hydrophobic silica nanoparticles on the copper mesh.	Water	21-26	alcohol dehydrogenase iron containing 1	Homo sapiens	17-20
29100161-4	2018	In this study, a hot water-repellent superhydrophobic mesh used for oil/water separation was prepared with one-step spray of modified polyurethane and hydrophobic silica nanoparticles on the copper mesh.	Water	72-77	alcohol dehydrogenase iron containing 1	Homo sapiens	17-20
29527428-3	2018	The resulting CNF/PVA/GO aerogels were synthesized through an environmentally friendly freeze-drying process and then carbonized to yield CNF/PVA/GO carbon aerogels with low density (18.41 mg cm-3), high porosity (98.98%), a water contact angle of 156  (super-hydrophobic) and high oil absorption capacity (97 times its own weight).	Water	225-230	NPHS1 adhesion molecule, nephrin	Homo sapiens	14-17
29527428-3	2018	The resulting CNF/PVA/GO aerogels were synthesized through an environmentally friendly freeze-drying process and then carbonized to yield CNF/PVA/GO carbon aerogels with low density (18.41 mg cm-3), high porosity (98.98%), a water contact angle of 156  (super-hydrophobic) and high oil absorption capacity (97 times its own weight).	Water	225-230	NPHS1 adhesion molecule, nephrin	Homo sapiens	138-141
8654562-4	1996	These results are discussed in terms of the light-induced formation of a bound OH" radical shared between the Cyt b-559 heme Fe and the Mn cluster as a first step of water oxidation.	Water	166-171	mitochondrially encoded cytochrome b	Homo sapiens	110-115
29303596-11	2018	The complexes and other previously reported compounds were employed as photosensitizers (PS) in preliminary studies on the production of H2 from water using [Co(bpy)3]Cl2 (bpy = 2,2"-bipyridine) as catalyst and triethanolamine (TEOA) as the sacrificial reductant.	Water	145-150	endogenous retrovirus group W member 5	Homo sapiens	167-170
8612510-8	1996	The results suggest strongly that cNOS is involved in long term modulation of the hypothalamo-neurohypophysial system and, hence, body water and electrolyte homeostasis, and that cNOS is itself regulated by body osmotic status.	Water	135-140	nitric oxide synthase 3	Rattus norvegicus	34-38
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	199-204	insulin receptor related receptor	Homo sapiens	104-107
8743747-4	1996	After 4 days of water deprivation secretogranin II mRNA was significantly increased in supraoptic nucleus (366 +/- 21% of control, P &lt; 0.01), the magnocellular paraventricular nucleus (209 +/- 20% of control, P &lt; 0.01) and the parvocellular paraventricular nucleus (147 +/- 6% of control, P &lt; 0.	Water	16-21	secretogranin II	Rattus norvegicus	34-50
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	199-204	insulin receptor related receptor	Homo sapiens	104-107
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	199-204	insulin receptor related receptor	Homo sapiens	104-107
8697097-4	1996	Carboxypeptidase B from the pancreas of the ostrich was purified by water extraction of acetone powder and aminobenzylsuccinic acid affinity and hydroxylapatite chromatography.	Water	68-73	carboxypeptidase B1	Homo sapiens	0-18
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	199-204	insulin receptor related receptor	Homo sapiens	104-107
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	199-204	insulin receptor related receptor	Homo sapiens	104-107
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	199-204	insulin receptor related receptor	Homo sapiens	104-107
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	199-204	insulin receptor related receptor	Homo sapiens	104-107
8727616-0	1996	Gram-negative bacteremia in open-heart-surgery patients traced to probable tap-water contamination of pressure-monitoring equipment.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	493-498	insulin receptor related receptor	Homo sapiens	104-107
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	493-498	insulin receptor related receptor	Homo sapiens	104-107
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	493-498	insulin receptor related receptor	Homo sapiens	104-107
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	493-498	insulin receptor related receptor	Homo sapiens	104-107
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	493-498	insulin receptor related receptor	Homo sapiens	104-107
8724421-0	1996	Determination of 1H relaxation times of water in human bone marrow by fat-suppressed turbo spin echo in comparison to MR spectroscopic methods.	Water	40-45	spindlin 1	Homo sapiens	91-95
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	493-498	insulin receptor related receptor	Homo sapiens	104-107
29402307-7	2018	RESULTS: Quantitative results found that age (IRR = 1.112, 95% CI 1.070-1.156) and region of residence (IRR = 0.855, 95% CI 0.780-0.937; IRR = 0.910, 95% CI 0.834-0.993) were important predictors of water intake in males, while age (IRR = 1.103, 95% CI 1.054-1.153), region of residence (IRR = 0.907, 95% CI 0.844-0.975; IRR = 1.258, 95% CI 1.130-1.400), ethnicity (IRR = 0.919, 95% CI 0.834-1.013) and marital status (IRR = 1.051, 95% CI 0.999-1.106) were found to be important predictors of water intake among females.	Water	493-498	insulin receptor related receptor	Homo sapiens	104-107
29393879-7	2018	Satisfactory recoveries were obtained for tap water (86.6-105.9%) and river water samples (82.9-107.1%), with relative standard deviations &lt;10% under optimal conditions.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
8616593-2	1996	Animals administered with aFGF showed significantly lower aversion threshold for saccharin at the 1st day and preference ratios for saccharin vs distilled water at the 4th, 6th, and 7th day after the conditioning than those administered with denatured aFGF.	Water	155-160	fibroblast growth factor 1	Rattus norvegicus	26-30
28956169-0	2018	Clinical improvement of patients with osteoarthritis using thermal mineral water at Szigetvar Spa-results of a randomised double-blind controlled study.	Water	75-80	surfactant protein A2	Homo sapiens	94-97
8637930-0	1996	Systemic administration of cholecystokinin (CCK) inhibits operant water intake in rats: implications for the CCK-satiety hypothesis.	Water	66-71	cholecystokinin	Rattus norvegicus	27-42
8637930-0	1996	Systemic administration of cholecystokinin (CCK) inhibits operant water intake in rats: implications for the CCK-satiety hypothesis.	Water	66-71	cholecystokinin	Rattus norvegicus	44-47
8637930-5	1996	Such a paradigm has the merit of slowing down the rate at which a water-deprived rat can quench its thirst, thus extending the period over which the effects of CCK-8S on water intake may be assessed.	Water	66-71	cholecystokinin	Rattus norvegicus	160-163
8637930-5	1996	Such a paradigm has the merit of slowing down the rate at which a water-deprived rat can quench its thirst, thus extending the period over which the effects of CCK-8S on water intake may be assessed.	Water	170-175	cholecystokinin	Rattus norvegicus	160-163
28956169-14	2018	Our double-blind study provided evidence for the beneficial health effects of another Hungarian thermal mineral water masking the colour, odour and pH of the tap water and mineral water.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	158-161
8637930-8	1996	Additional experiments indicated that, as with feeding, CCK-8S inhibits water intake by an action at peripheral CCKA receptors.	Water	72-77	cholecystokinin	Rattus norvegicus	56-59
28956169-14	2018	Our double-blind study provided evidence for the beneficial health effects of another Hungarian thermal mineral water masking the colour, odour and pH of the tap water and mineral water.	Water	162-167	nuclear RNA export factor 1	Homo sapiens	158-161
28956169-14	2018	Our double-blind study provided evidence for the beneficial health effects of another Hungarian thermal mineral water masking the colour, odour and pH of the tap water and mineral water.	Water	162-167	nuclear RNA export factor 1	Homo sapiens	158-161
31352923-3	2018	In this study, to improve water dispersity and the anti-tumor efficiency of SN-38, a prodrug, SN-38-BOC, that could efficiently transform to active SN-38 in the acidic tumor microenvironment was synthesized and encapsulated into MPEG-P(CL-ran-TMC) micelles (SN-38-BOC micelles).	Water	26-31	BOC cell adhesion associated, oncogene regulated	Homo sapiens	100-103
8613263-3	1996	The antidiuretic effect of Ang-(1-7) (40 pmol/0.05 mL per 100 g BW) in water-loaded rats was completely blocked by A-779 (vehicle-treated, 3.34 +/- 0.43 mL/h; Ang-(1-7), 1.48 +/- 0.23; A-779, 2.72 +/- 0.35; Ang-(1-7) plus A-779, 3.26 +/- 0.49).	Water	71-76	angiogenin	Rattus norvegicus	27-35
8613263-6	1996	The antidiuretic effect of Ang-(1-7) in water-loaded rats was associated with a reduction of creatinine clearance (0.68 +/- 0.04 versus 1.38 +/- 0.32 mL/min in vehicle-treated rats, P &lt;.05) and an increase in urine osmolality (266.8 +/- 32.7 versus 182.8 +/- 14 mOsm/kg in vehicle-treated rats, P &lt;.05).	Water	40-45	angiogenin	Rattus norvegicus	27-35
8613263-7	1996	An effect of Ang-(1-7) in tubular water transport was demonstrated in vitro by a fourfold increase in the hydraulic conductivity of inner medullary collecting ducts in the presence of 1 nmol/L Ang-(1-7).	Water	34-39	angiogenin	Rattus norvegicus	13-21
8613263-7	1996	An effect of Ang-(1-7) in tubular water transport was demonstrated in vitro by a fourfold increase in the hydraulic conductivity of inner medullary collecting ducts in the presence of 1 nmol/L Ang-(1-7).	Water	34-39	angiogenin	Rattus norvegicus	193-201
8613263-11	1996	These findings suggest that endogenous Ang-(1-7), acting on specific receptors, participates in the control of hydroelectrolyte balance by influencing especially water excretion.	Water	162-167	angiogenin	Rattus norvegicus	39-47
9132417-8	1996	Preincubation of water-soluble pea porin with the plant sterol beta-sitosterol resulted in a considerable higher channel-forming activity than with all the other sterols used for preincubation.	Water	17-22	outer plastidial membrane protein porin	Zea mays	35-40
9296638-2	1997	Proteolysis of protein-DNAse 1 inhibitor in water phase under combined action of low constant and alternating magnetic fields adjusted to cyclotron resonance of polar amino acid ions].	Water	44-49	deoxyribonuclease 1	Homo sapiens	23-30
9193982-1	1997	OBJECTIVE: To investigate the bacterial cleanliness of tap water in a large accident and emergency (A&amp;E) department for its possible use in the cleansing and irrigation of open traumatic wounds.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
9193982-2	1997	METHODS: Tap water samples were collected from different areas within the department and analysed on two separate occasions for coliforms, S aureus, clostridia, pseudomonas, and beta haemolytic streptococci.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
9193982-4	1997	CONCLUSIONS: Tap water of drinking quality can be used to irrigate open traumatic wounds.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
29133107-3	2018	In most cases NMOSD are associated with autoantibodies targeting the water channel aquaporin-4 (AQP-4).	Water	69-74	aquaporin 4	Homo sapiens	96-101
11038971-2	1997	Compared with oleanolic acid and sodium chloride physiological solution, the water decoction of and the total saponin in root and cortex of Aralia taibaiensis were testified to have significant protective activity in experimental acute liver injury in mice induced by CCl4.	Water	77-82	chemokine (C-C motif) ligand 4	Mus musculus	268-272
29371696-0	2018	Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88"s effects on the gut microbiota.	Water	9-14	myeloid differentiation primary response gene 88	Mus musculus	75-80
9116284-4	1997	The amount of platelet GPIb alpha and the plasma glycocalicin concentration, the water-soluble extracellular portion of GPIb alpha, were also decreased.	Water	81-86	glycoprotein Ib platelet subunit alpha	Homo sapiens	120-130
8602703-9	1996	In the case-control study, persons who drank any unboiled tap water were four times more likely than persons who drank only bottled water to have had cryptosporidiosis (odds ratio, 4.22 [95% Cl, 1.22 to 14.65]; P = 0.02).	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
29371696-5	2018	Mechanistically, microarray analysis revealed that hydrogen-water administration upregulated miR-1968-5p levels, thus resulting in parallel downregulation of MyD88 expression in the small intestine after TAI exposure.	Water	60-65	myeloid differentiation primary response gene 88	Mus musculus	158-163
9118599-1	1996	Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Gwynedd, Wales, UK which contains approximately 0.3 mg of iron per ml as ferrous sulphate.	Water	51-56	surfactant protein A2	Homo sapiens	0-3
29308502-1	2018	Based on high-resolution STM imaging/manipulations and DFT calculations, we display the dynamic hydration process of adenine networks on Au(111) in real space, which results in controllable scission and stitching of adenine structures by water molecules.	Water	238-243	sulfotransferase family 1A member 3	Homo sapiens	25-28
8820413-10	1996	These findings are in agreement with the results of earlier CD and NMR conformational studies of galanin in water and non-aqueous solvents.	Water	108-113	galanin and GMAP prepropeptide	Homo sapiens	97-104
9108308-2	1997	Models of Vpu channels formed by bundles of N = 4, 5 or 6 transmembrane helices have been developed by restrained molecular dynamics and refined by 100 ps simulations with water molecules within the pore.	Water	172-177	Vpu	Human immunodeficiency virus 1	10-13
9129978-15	1997	We conclude that the presence of the B27 gene is associated with a decreased incidence and slower rate of onset of EAU following immunization with IRBP; however, EAU may be more severe in the HLA-B27 expressing animals who do develop disease.	Water	115-118	retinol binding protein 3, interstitial	Mus musculus	147-151
29349297-1	2018	Direct evidence of complex prebiotic chemistry from a water-rich world in the outer solar system is provided by the 4.5-billion-year-old halite crystals hosted in the Zag and Monahans (1998) meteorites.	Water	54-59	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	167-170
9065397-3	1997	Current general circulation models suggest that the increase in the clear sky water vapor greenhouse effect with SST may have climatic effects on a planetary scale.	Water	78-83	somatostatin	Homo sapiens	113-116
8593803-12	1996	Similar effects were noted for ANF and MCH; both stimulated water, Na, and K fluxes at the proximal colon level and increased Na and K fluxes in the duodenum.	Water	60-65	natriuretic peptide A	Rattus norvegicus	31-34
8593803-13	1996	However, only ANF increased water and Cl fluxes in the duodenum and decreased bicarbonate secretion in the ileum, whereas MCH increased bicarbonate absorption in the jejunum.	Water	28-33	natriuretic peptide A	Rattus norvegicus	14-17
28759849-5	2018	This proposed strategy was also demonstrated the possibility to be used for Hg2+ detection in water samples.	Water	94-99	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	76-79
8762348-1	1996	STUDY OBJECTIVES: To investigate whether exposure to tap water contaminated in a major river pollution incident with 2 ethyl 5,5 dimethyl 1,3 dioxane (EDD) and 2 ethyl 4 methyl 1,3 dioxolane (EMD) was associated with an increase of self reported symptoms.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
8762348-15	1996	Because concentrations of the contaminants would be expected to be evenly distributed in the tap water in the affected area, irrespective of taste or odour, and because of the known toxicity of the parent compounds of EMD and EDD, it is concluded that the increase in self reported symptoms in the study group respondents was associated with noticing the unpleasant taste or odour of the tap water and not with the chemical contamination.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
30393297-0	2018	A Changeable Lab-on-a-Chip Detector for Marine Nonindigenous Microorganisms in Ship"s Ballast Water.	Water	94-99	inositol polyphosphate-5-phosphatase D	Homo sapiens	79-83
8661821-4	1996	In this study we evaluated the effects of CCK and PYY on intestinal absorption of water and electrolytes.	Water	82-87	cholecystokinin	Canis lupus familiaris	42-45
29526907-3	2018	The developed on-line PIEC ion stacking-ion chromatography method was validated by recovery experiments for the determination of nitrate in tap water in terms of both accuracy and precision, and the results showed the reliability of the method.	Water	144-149	nuclear RNA export factor 1	Homo sapiens	140-143
8611645-5	1996	Within 30-60 min incubation at 37 degrees C in water or in phosphate-buffered saline solution (PBS), beta 25-35 was almost fully converted to a beta-sheet structure.	Water	47-52	amyloid beta precursor protein	Rattus norvegicus	142-148
29128835-7	2018	PAMAM moieties enhanced the hydrophilicity of the fibers, as proved by comparing the water absorption for the PCL/PAMAM-PCL fibers to that neat PCL fibers.	Water	85-90	PHD finger protein 1	Homo sapiens	110-113
29128835-7	2018	PAMAM moieties enhanced the hydrophilicity of the fibers, as proved by comparing the water absorption for the PCL/PAMAM-PCL fibers to that neat PCL fibers.	Water	85-90	PHD finger protein 1	Homo sapiens	120-123
29128835-7	2018	PAMAM moieties enhanced the hydrophilicity of the fibers, as proved by comparing the water absorption for the PCL/PAMAM-PCL fibers to that neat PCL fibers.	Water	85-90	PHD finger protein 1	Homo sapiens	120-123
8834861-4	1996	Analysis of chloroform and trichloethene in expired breath, compounds regulated in water, was also used to determine uptake from tap water by each route (inhalation, ingestion, or absorption).	Water	133-138	nuclear RNA export factor 1	Homo sapiens	129-132
29111994-13	2018	CONCLUSIONS: Tap water distilled locally in surgical facilities may be a source of infection after ocular surgery and its use should be avoided.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
8804004-3	1996	Tap water must be considered as the main source of dialysate trace metal contamination.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
8742959-6	1996	Free water clearance also increased from 11.5 +/- 3.7 to 14.4 +/- 3.9 ml/min, indicating an increase in TALH reabsorption which was attributed to increased sodium and water reaching this segment.	Water	5-10	transaldolase 1	Homo sapiens	104-108
8742959-6	1996	Free water clearance also increased from 11.5 +/- 3.7 to 14.4 +/- 3.9 ml/min, indicating an increase in TALH reabsorption which was attributed to increased sodium and water reaching this segment.	Water	167-172	transaldolase 1	Homo sapiens	104-108
9153797-1	1996	The spin lattice relaxation time (T1) and spin spin relaxation time (T2) of water protons of normal human and animal tissues are archived to up-date those already published.	Water	76-81	spindlin 1	Homo sapiens	4-8
8711190-6	1996	Also the tap water samples presented a low concentration of these substances.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
9863219-3	1996	The results showed that pretreatment with H-7 6.25 and 12.5 mg.kg-1 prevented the accumulation of water and certain electrolytes in the unilateral hemisphere of the brain evoked by ligation of a single common carotid artery in Mongolian gerbil; pretreatment with matrine 25 and 50 mg.kg-1 reduced the extent of cerebral edema formation evoked by ligation of a single common carotid artery in gerbil and by middle cerebral artery occlusion in Sprague-Dawley rats.	Water	98-103	solute carrier family 9 member A2	Rattus norvegicus	42-45
8549742-4	1995	The NOESY spectrum in 90% H2O + 10% 2H2O has been used to assign all observable imino and amino protons including those involved in the A+(anti)-G(syn) base pair.	Water	26-29	synemin	Homo sapiens	147-150
8575435-10	1995	The calculated spectral parameters could be modelled with the measured parameters if the solvent ligand is H2O in free ACE, carboxylate from ramiprilat in the ACE-ramiprilat complex and a mercapto group in the ACE-captopril complex.	Water	107-110	angiotensin-converting enzyme	Oryctolagus cuniculus	119-122
8575435-10	1995	The calculated spectral parameters could be modelled with the measured parameters if the solvent ligand is H2O in free ACE, carboxylate from ramiprilat in the ACE-ramiprilat complex and a mercapto group in the ACE-captopril complex.	Water	107-110	angiotensin-converting enzyme	Oryctolagus cuniculus	159-162
8575435-10	1995	The calculated spectral parameters could be modelled with the measured parameters if the solvent ligand is H2O in free ACE, carboxylate from ramiprilat in the ACE-ramiprilat complex and a mercapto group in the ACE-captopril complex.	Water	107-110	angiotensin-converting enzyme	Oryctolagus cuniculus	159-162
8846081-7	1995	These results indicated that the transplanted cells continued expressing the c-fos transgene when the rats were given drinking water containing zinc, resulting in the promotion of cell growth and of neovascularization.	Water	127-132	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	77-82
8586887-11	1995	From these findings described above, we diagnosed the patient as pneumonia due to L. pneumophila SG3, and the spa water was the most probable source of infection.	Water	114-119	surfactant protein A2	Homo sapiens	110-113
9084392-0	1997	Reducing the incidence of tap-water scalds: strategies for physicians.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
9084392-4	1997	Tap-water scalds are preventable.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
9141059-4	1997	Maternal exposure to 0.2% lead acetate in drinking water from gestational day 16 resulted in an approximately 30% reduction of VAChT in 7 and 21-day-old rat pups without affecting VAChT mRNA levels in the dams.	Water	51-56	solute carrier family 18 member A3	Rattus norvegicus	127-132
9469794-12	1997	Subsequent infusion of ANF further reduced blood pressure but increased sodium and water excretion markedly.	Water	83-88	natriuretic peptide A	Rattus norvegicus	23-26
9050237-10	1997	Recent studies have suggested models whereby extracellular Ca2+, via the CaSR expressed in the TAL as well as in the collecting duct system, modulates both Ca2+ 0 and Mg2+ 0 as well as water reabsorbtion.	Water	185-190	transaldolase 1	Homo sapiens	95-98
9273663-7	1997	Tap water in Poznan contained 0.2 mg F3/dm3, on average.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
9505333-2	1997	Tap water was exchanged for a 24% EDTA solution as irrigation agent during root planing with a piezo scaler.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
9017229-2	1996	Microinjections of the selective tachykinin NK-3 receptor agonist senktide (2-200 pmol) into the PVN resulted in prolonged inhibition of urine output in water-loaded rats, its effect being dose-dependent.	Water	153-158	tachykinin receptor 3	Rattus norvegicus	44-57
30636608-2	2018	Here we compared the differences in morphology, pathology, visual function of the retinal inflammation and Th1/Th17 immune responses in the EAU models induced by the interphotoreceptor retinoid binding protein (IRBP) between the B10.RIII and C57BL/6 strains, using fundus and histological examinations, optical coherence tomography, electroretinography and immunoassays.	Water	140-143	retinol binding protein 3, interstitial	Mus musculus	166-209
8978095-5	1996	Cells of plb1 delta mutant showed increased survival when cells of plb1 delta mutant and wild-type strain were incubated in water at 30 degrees C. Cells of PLB1-over-expressed strain died rapidly even during the cultivation period, indicating that phospholipase B activity may be a determinant for the survival of this yeast.	Water	124-129	lysophospholipase	Saccharomyces cerevisiae S288C	9-13
8978095-5	1996	Cells of plb1 delta mutant showed increased survival when cells of plb1 delta mutant and wild-type strain were incubated in water at 30 degrees C. Cells of PLB1-over-expressed strain died rapidly even during the cultivation period, indicating that phospholipase B activity may be a determinant for the survival of this yeast.	Water	124-129	lysophospholipase	Saccharomyces cerevisiae S288C	67-71
30636608-2	2018	Here we compared the differences in morphology, pathology, visual function of the retinal inflammation and Th1/Th17 immune responses in the EAU models induced by the interphotoreceptor retinoid binding protein (IRBP) between the B10.RIII and C57BL/6 strains, using fundus and histological examinations, optical coherence tomography, electroretinography and immunoassays.	Water	140-143	retinol binding protein 3, interstitial	Mus musculus	211-215
11667857-3	1996	The proportion of syn isomers reached a maximum (syn/anti = 5.6:1) when the neighboring hydroxyl group was unprotected and water was the reaction medium.	Water	123-128	synemin	Homo sapiens	18-21
11667857-3	1996	The proportion of syn isomers reached a maximum (syn/anti = 5.6:1) when the neighboring hydroxyl group was unprotected and water was the reaction medium.	Water	123-128	synemin	Homo sapiens	49-52
30636608-6	2018	These data demonstrate distinguishing features of retinal inflammation and T-cell immune responses involved in IRBP-induced EAU between B10.RIII and C57BL/6 strains.	Water	124-127	retinol binding protein 3, interstitial	Mus musculus	111-115
28826030-0	2018	Synthesis and characterization of triazole based supramolecule for interaction with cefuroxime in tap water and blood plasma.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
9001172-7	1996	These findings indicate that the chronic use of Colyte osmotic laxative in drinking water is an economical means of greatly increasing the survival of CFTR knockout mice without altering the major electrolyte transport processes or histomorphologic integrity of the intestine.	Water	84-89	cystic fibrosis transmembrane conductance regulator	Mus musculus	151-155
8982415-0	1996	Successful treatment of dyshidrotic hand eczema using tap water iontophoresis with pulsed direct current.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
8982415-1	1996	The efficacy of tap water iontophoresis in treating palmoplantar hyperhidrosis has been sufficiently documented and has led to its extensive use in clinical practice.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
8982415-2	1996	In order to test the efficacy of this treatment modality in cases of dyshidrotic hand eczema, 20 patients were treated with tap water iontophoresis in addition to two-sided steroid-free topical therapy in a randomized half-side-study.	Water	128-133	nuclear RNA export factor 1	Homo sapiens	124-127
8982415-4	1996	Only those sides treated with tap water iontophoresis showed significant improvement.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
8918374-1	1996	Three members of the water channel (aquaporin) family are expressed in adult rat lung: CHIP28 (AQP-1), MIWC (AQP-4), and AQP-5.	Water	21-26	aquaporin 5	Rattus norvegicus	121-126
9230462-0	1996	Solution conformation of [D-Pen2, D-Pen5] enkephalin in water: a NMR and molecular dynamics study.	Water	56-61	presenilin enhancer, gamma-secretase subunit	Homo sapiens	28-32
8938905-5	1996	RESULTS: The IBS patients had reduced motilin secretion after both water intake and the fat meal.	Water	67-72	motilin	Homo sapiens	38-45
8906873-4	1996	17.6 kDa, consistent with this representing a catalytic domain of HSL capable of hydrolysing water-soluble but not lipid substrates.	Water	93-98	lipase E, hormone sensitive type	Homo sapiens	66-69
8897973-0	1996	Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats.	Water	63-68	glucagon	Rattus norvegicus	26-31
8897973-5	1996	GLP-1 effects on water intake and output were also investigated.	Water	17-22	glucagon	Rattus norvegicus	0-5
8897973-6	1996	Intracerebroventricular GLP-1 profoundly inhibited angiotensin II-induced drinking behavior in rats, and water intake was suppressed by exogenous GLP-1 in rats habituated to a water restriction schedule.	Water	176-181	glucagon	Rattus norvegicus	146-151
8897973-8	1996	Furthermore, intracerebroventricular GLP-1 stimulated urinary excretion of water and sodium.	Water	75-80	glucagon	Rattus norvegicus	37-42
8897973-11	1996	In conclusion, GLP-1 may play a physiological role in regulation of both ingestion and the water and salt homeostasis.	Water	91-96	glucagon	Rattus norvegicus	15-20
8902118-0	1996	Use of sterile compared with tap water in gastrointestinal endoscopic procedures.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
8902118-13	1996	Our pilot study suggests that the use of tap water as compared with sterile water may be practical as well as provide cost savings.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
8896808-5	1996	ANP was found to inhibit the water intake and corticosterone release induced by i.c.v.	Water	29-34	natriuretic peptide A	Rattus norvegicus	0-3
21619368-11	1996	An excellent agreement was found between the results obtained for standard solutions prepared using NANOpure water and spiked tap water samples.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
8873995-13	1996	In the minor groove the cytosine carbonyl oxygen atoms of the GpC and CpG steps are cross-bridged by water molecules that are not themselves hydrogen bonded but are enclosed by the water rings in the mouth of the minor groove.	Water	101-106	glycophorin C (Gerbich blood group)	Homo sapiens	62-65
8873995-13	1996	In the minor groove the cytosine carbonyl oxygen atoms of the GpC and CpG steps are cross-bridged by water molecules that are not themselves hydrogen bonded but are enclosed by the water rings in the mouth of the minor groove.	Water	181-186	glycophorin C (Gerbich blood group)	Homo sapiens	62-65
8881706-4	1996	However, intracellular water standardized per litre TBW was significantly higher in CPB subjects (mean 27.0 (SD 7.5); P &lt; 0.01) compared with CPA (mean 21.3 (SD 10.6)) and control subjects (mean 18.0 (SD 9.8)).	Water	23-28	carboxypeptidase B1	Homo sapiens	84-87
8918692-2	1996	EAU is induced by immunization of B10.A mice with interphotoreceptor retinoid-binding protein (IRBP).	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	50-93
8918692-2	1996	EAU is induced by immunization of B10.A mice with interphotoreceptor retinoid-binding protein (IRBP).	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	95-99
8918692-3	1996	Pre-treatment with synthetic peptide 518-529 derived from IRBP prevented IRBP-mediated EAU.	Water	87-90	retinol binding protein 3, interstitial	Mus musculus	58-62
8918692-3	1996	Pre-treatment with synthetic peptide 518-529 derived from IRBP prevented IRBP-mediated EAU.	Water	87-90	retinol binding protein 3, interstitial	Mus musculus	73-77
8765213-11	1996	At 24 hours after injury, EGF-R mRNA levels were increased 36-fold over the water-fed controls, and this increase was not significantly affected by tyrphostin.	Water	76-81	epidermal growth factor receptor	Rattus norvegicus	26-31
8694793-4	1996	The enhanced water permeability was inhibited by 65% by coinjection of poly(A)+ RNA with antisense aquaporin-5 but not antisense aquaporin-1 oligonucleotide.	Water	13-18	aquaporin 5	Rattus norvegicus	99-110
8694793-7	1996	Our results strongly suggest that rat lacrimal glands express aquaporin-5 water channels for lacrimation.	Water	74-79	aquaporin 5	Rattus norvegicus	62-73
8664315-6	1996	An 11-fold increase in 5-methyltetrahydrofolate (5-MTHF) uptake was observed in oocytes injected with 10 ng IFC1(RFC1) cRNA compared to water-injected controls.	Water	136-141	solute carrier family 19 (folate transporter), member 1	Mus musculus	108-112
8650246-0	1996	The heart communicates with the kidney exclusively through the guanylyl cyclase-A receptor: acute handling of sodium and water in response to volume expansion.	Water	121-126	natriuretic peptide receptor 1	Mus musculus	63-81
8774233-1	1996	A colorimetric method was used on water-soluble mucin extracted from mucosal scrapings and contents of the caecum and the colon of five germ-free (GF) rats and five heteroxenic (HE) rats harbouring a human flora (GF rats associated with a human flora).	Water	34-39	solute carrier family 13 member 2	Rattus norvegicus	48-53
20953017-9	1995	It showed that methenamine is superior to tap water iontophoresis and acts faster than glutaraldehyde.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
8617688-11	1995	But because more water is stored with deposited protein than with deposited fat, lean tissue gain is four times as efficient as accretion of fat tissue.	Water	17-22	FAT atypical cadherin 1	Bos taurus	141-144
8574331-7	1995	In control rats, the administration of the liquid meal increased the plasma CCK concentration and significantly decreased the intestinal CCK content in water extracts, but did not affect the amount extracts in acid whereas the ingestion of the meal did not cause any significant changes in rats treated with CR-1505.	Water	152-157	cholecystokinin	Rattus norvegicus	137-140
8569068-3	1995	We have cloned three kidney cDNAs with homology to the water channel (aquaporin) family, including a mercurial-insensitive water channel (MIWC), and a glycerol-transporting protein (GLIP) in collecting duct basolateral membrane.	Water	55-60	aquaporin 4	Homo sapiens	101-136
8569068-3	1995	We have cloned three kidney cDNAs with homology to the water channel (aquaporin) family, including a mercurial-insensitive water channel (MIWC), and a glycerol-transporting protein (GLIP) in collecting duct basolateral membrane.	Water	55-60	aquaporin 4	Homo sapiens	138-142
8570142-1	1995	Parvalbumin (PA) is a water soluble, low-molecular weight, calcium-binding protein which has been thought to be involved in the relaxation of skeletal muscle fibers.	Water	22-27	parvalbumin	Rattus norvegicus	0-11
7573412-0	1995	Water channel-carrying vesicles in the rat IMCD contain cellubrevin.	Water	0-5	vesicle-associated membrane protein 3	Rattus norvegicus	56-67
7573412-4	1995	We now show by immunogold electron microscopy that cellubrevin is present on vesicles containing water channels, that it is associated with both coated and uncoated vesicles, and that it is present on the apical membrane.	Water	97-102	vesicle-associated membrane protein 3	Rattus norvegicus	51-62
7573412-5	1995	Cellubrevin, therefore, is in a position to mediate one or more steps in arginine vasopressin-induced water channel cycling.	Water	102-107	vesicle-associated membrane protein 3	Rattus norvegicus	0-11
7474653-1	1995	The renal kallikrein-kinin system has been implicated in the regulation of blood pressure and sodium/water excretion.	Water	101-106	kallikrein related peptidase 4	Homo sapiens	10-20
7474658-4	1995	However, the concomitant treatment with difluoromethylornithine (DFMO), an irreversible inhibitor of ODC, as a 2% solution in the drinking water completely abolished the increase of renal ODC, but the kidney weights increased and other androgenic effects, such as the induction of renal beta-glucuronidase, were not affected.	Water	139-144	ornithine decarboxylase, structural 1	Mus musculus	101-104
7640284-0	1995	Pulmonary surfactant protein SP-A with phospholipids in spread monolayers at the air-water interface.	Water	85-90	surfactant protein A2	Homo sapiens	29-33
7485985-4	1995	For peptides corresponding to polypeptide segments of a membrane protein, the human red cell glucose transporter (Glut1), the retention volumes increased with decreasing water-to-oil transfer free energy of the peptides and were related to the transfer free energy distribution within the peptides as shown by hydropathy plots and to the presence of cysteine.	Water	170-175	solute carrier family 2 member 1	Homo sapiens	114-119
7547424-0	1995	Clinical and biological effects of balneotherapy with selenium-rich spa water in patients with psoriasis vulgaris.	Water	72-77	surfactant protein A2	Homo sapiens	68-71
7641840-6	1995	Legionellae were present in the spa water at low concentrations, generally lower than 10(3) c.f.u./l.	Water	36-41	surfactant protein A2	Homo sapiens	32-35
7558823-1	1995	Tap water iontophoresis with direct current represents the therapy of choice in palmoplantar hyperhidrosis.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
7558823-4	1995	The aim of this study was to find ways of minimizing side effects, increasing safety standards and reducing the technical complications of tap water iontophoresis without loss of efficacy.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
7558823-5	1995	In a blind study, 30 patients with palmar hyperhidrosis were treated with tap water iontophoresis using pulsed direct current of 4.3 kHz or 10.0 kHz.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
7558823-12	1995	Because of the minimal side effects, despite minor loss of efficacy tap water iontophoresis with pulsed direct current can be a valuable alternative treatment for palmar hyperhidrosis.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
7609172-4	1995	Complications are relatively minor and tap water appears to be a safe solution for the antegrade continence enema.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
7542475-1	1995	The three-dimensional structure of the bovine pancreatic trypsin inhibitor (BPTI) contains 4 internal water molecules, denoted W111, W112, W113, and W122, the latter being replaced by a seryl side chain in the BPTI(G36S) analogue.	Water	102-107	spleen trypsin inhibitor I	Bos taurus	76-80
7542475-3	1995	A comparison of the data from the two nuclei shows unequivocally that the isolated buried water molecule, W122, of BPTI contributes only to 2H, but not to 17O relaxation, while the other 3 waters contribute fully to the relaxation of both nuclei.	Water	90-95	spleen trypsin inhibitor I	Bos taurus	115-119
7631892-3	1995	By contrast, water intake and urine volume were markedly elevated in the TTR-ANF group on either diet.	Water	13-18	transthyretin	Mus musculus	73-76
28826030-8	2018	Supramolecule 5 displayed fairly good spectrophotometric recognition of Cefuroxime in human blood plasma and tap water thus showing that the ingredients of tap water and plasma sample was inert in the recognition of cefuroxime.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
28826030-8	2018	Supramolecule 5 displayed fairly good spectrophotometric recognition of Cefuroxime in human blood plasma and tap water thus showing that the ingredients of tap water and plasma sample was inert in the recognition of cefuroxime.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	156-159
8520076-6	1995	A 20-mL/kg water-load test was administered to each patient.	Water	11-16	immunoglobulin kappa variable 1-27	Homo sapiens	0-4
28826030-8	2018	Supramolecule 5 displayed fairly good spectrophotometric recognition of Cefuroxime in human blood plasma and tap water thus showing that the ingredients of tap water and plasma sample was inert in the recognition of cefuroxime.	Water	160-165	nuclear RNA export factor 1	Homo sapiens	156-159
29354275-4	2018	The structures reveal new intermediate solvent states of hCA II that provide crystallographic snapshots during the restoration of the proton-transfer water network in the active site.	Water	150-155	carbonic anhydrase 2	Homo sapiens	57-63
29354275-8	2018	This study provides the first "physical" glimpse of how a water reservoir flows into the hCA II active site during its catalytic activity.	Water	58-63	carbonic anhydrase 2	Homo sapiens	89-95
29218634-2	2018	N2OR is the terminal reductase in a respiratory chain converting N2O to N2 in denitrifying bacteria; COX is the terminal oxidase of the aerobic respiratory chain of certain bacteria and eukaryotic organisms transforming O2 to H2O accompanied by proton pumping.	Water	226-229	cytochrome c oxidase subunit 7A1	Bos taurus	101-104
29463369-4	2018	The NCTD-loaded polymeric nanoparticles (MPG/NCTD) formed by self-assembly in water exhibited a mean hydrodynamic diameter of roughly 89 nm.	Water	78-83	N-methylpurine DNA glycosylase	Homo sapiens	41-44
28321903-9	2018	Spin-lock imaging may therefore provide specific quantification of iohexol concentration and the iohexol-water exchange rate, which reports on pH.	Water	105-110	spindlin 1	Rattus norvegicus	0-4
30533342-2	2018	Here we report how hydroxyl radicals ( OH) injected on the surface of water react with SP-B1-25, a 25-residue polypeptide surrogate of human lung surfactant protein B.	Water	70-75	prolyl 3-hydroxylase 3	Homo sapiens	157-166
29126634-15	2018	Before introducing the AED into the NGT, 93% of the nurses reported mixing with tap water.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
29713108-0	2017	Volcano and ship tracks indicate excessive aerosol-induced cloud water increases in a climate model.	Water	65-70	inositol polyphosphate-5-phosphatase D	Homo sapiens	12-16
29713108-2	2017	By combining satellite retrievals of volcano and ship tracks in stratocumulus clouds, we compile a unique observational dataset and confirm that liquid water path (LWP) responses to aerosols are bidirectional, and on average the increases in LWP are closely compensated by the decreases.	Water	152-157	inositol polyphosphate-5-phosphatase D	Homo sapiens	49-53
29210387-3	2017	The results show that H3O+ accumulates at the membrane surface where it displaces water and forms strong and long-lived hydrogen bonds with the phosphate and carbonyl oxygens in phospholipids.	Water	82-87	H3 clustered histone 15	Homo sapiens	22-25
29148771-2	2017	Specifically, AAG uses a water molecule activated by a general base and a nonspecific active site lined with aromatic residues to cleave the N-glycosidic bond.	Water	25-30	N-methylpurine DNA glycosylase	Homo sapiens	14-17
29068453-7	2017	Both IL-4 and IL-17A AUC values were significantly increased after an SFA high-fat meal intake, accompanied by water, but not by orange juice.	Water	111-116	interleukin 17A	Homo sapiens	14-20
29068453-9	2017	Also, IL-17A significantly increased at 3 h after an SFA high-fat meal intake accompanied by water, but not by orange juice.	Water	93-98	interleukin 17A	Homo sapiens	6-12
29270018-1	2017	Numerous contemporary incidents demonstrate that conventional control strategies for municipal tap water have limited ability to mitigate exposures to chemicals whose sources are within distribution systems, such as lead, and chemicals that are not removed by standard treatment technologies, such as perfluorooctanoic acid (PFOA)/perfluorooctanesulfonic acid (PFOS).	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
29270018-3	2017	As an initial effort to fill this information gap, we conducted a critical review and analysis of the existing literature and data on the effectiveness of POU drinking water treatment technologies for reducing chemical contaminants commonly found in tap water in the United States.	Water	168-173	nuclear RNA export factor 1	Homo sapiens	250-253
29270018-3	2017	As an initial effort to fill this information gap, we conducted a critical review and analysis of the existing literature and data on the effectiveness of POU drinking water treatment technologies for reducing chemical contaminants commonly found in tap water in the United States.	Water	254-259	nuclear RNA export factor 1	Homo sapiens	250-253
29270018-4	2017	We found that many types of water treatment devices available to consumers in the United States have undergone laboratory testing and often certification for removal of chemical contaminants in tap water, but in most cases their efficacy in actual use has yet to be well characterized.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	194-197
29148785-2	2017	Specifically, using protein GB1 K28C-EDTA-Cu2+ mutant as a model, we show the determination of backbone amide 15N longitudinal and 1H transverse PREs within a few hours of experiment time based on proton-detected 2D or 3D correlation spectra recorded with magic-angle spinning frequencies &gt;= ~ 60 kHz for samples containing ~10-50 nanomoles of 2H,13C,15N-labeled protein back-exchanged in H2O.	Water	392-395	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	28-31
29251455-9	2017	Rosehip tea caused the most color changes, while tap water showed the least in all resin composites.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
28806690-5	2017	Dechlornane Plus stereoisomers (syn- and anti-DP) were detected in all samples, exhibiting relatively high concentrations in water, sediments and SPM.	Water	125-130	synemin	Homo sapiens	32-35
8823622-2	1996	Weakly water-soluble (colloidal) complex was formed upon addition of BSA.E to PVP (R2, R16) solution at pH 7.	Water	7-12	solute carrier family 1 member 5	Homo sapiens	87-90
28806690-6	2017	The maximum syn-DP concentrations in water, sediments and SPM were 24.30 ng/L, 2.48 ng/g dry wt.	Water	37-42	synemin	Homo sapiens	12-15
8725252-1	1996	Surfactant protein A (SP-A) is a 248-residue, water-soluble, lipid-associating protein found in lung surfactant.	Water	46-51	pulmonary surfactant-associated protein A	Oryctolagus cuniculus	0-20
8725252-1	1996	Surfactant protein A (SP-A) is a 248-residue, water-soluble, lipid-associating protein found in lung surfactant.	Water	46-51	pulmonary surfactant-associated protein A	Oryctolagus cuniculus	22-26
29072508-0	2017	The aquaporin-4 water channel as a potential drug target in neurological disorders.	Water	16-21	aquaporin 4	Mus musculus	4-15
8743440-6	1996	The mean log variant frequency of peripheral lymphocytes was significantly higher in the medium well water exposure group than in the low and medium tap water exposure groups.	Water	153-158	nuclear RNA export factor 1	Homo sapiens	149-152
29072508-1	2017	INTRODUCTION: Aquaporin-4 (AQP4) is a water transporting protein expressed at the plasma membrane of astrocytes throughout the central nervous system (CNS).	Water	38-43	aquaporin 4	Mus musculus	14-25
18966545-8	1996	Two different modes of standard addition (the standard lead solutions being added before and after preconcentration) were used for analysis of tap water samples, and the results obtained by the two modes were found to be quite consistent.	Water	147-152	nuclear RNA export factor 1	Homo sapiens	143-146
29072508-1	2017	INTRODUCTION: Aquaporin-4 (AQP4) is a water transporting protein expressed at the plasma membrane of astrocytes throughout the central nervous system (CNS).	Water	38-43	aquaporin 4	Mus musculus	27-31
29072508-2	2017	Analysis of AQP4 knockout mice has suggested its broad involvement in brain water balance, neuroexcitation, glial scarring, neuroinflammation, and even neurodegenerative and neuropsychiatric disorders.	Water	76-81	aquaporin 4	Mus musculus	12-16
29125630-1	2017	Aquaporin-4, a predominant water channel in the central nervous system, has two isoforms, M1 and M23, whose transcripts are driven by distinct promoters.	Water	27-32	aquaporin 4	Mus musculus	0-11
8928802-6	1996	Uroguanylin joins guanylin as an intestinal peptide that may participate in an intrinsic pathway for cGMP-mediated regulation of intestinal salt and water transport.	Water	149-154	guanylate cyclase activator 2B	Homo sapiens	0-11
8674384-11	1996	These data are consistent with the hypothesis that NHE3, but not NHE2, is involved in basal and meal-stimulated ileal water and Na+ absorption.	Water	118-123	solute carrier family 9 member A3	Homo sapiens	51-55
8799752-4	1996	Ultrafiltration is valuable in removing excess plasma water during CPB.	Water	54-59	carboxypeptidase B1	Homo sapiens	67-70
8867338-5	1996	Motilin on the other hand attains an alpha-helical structure at low water content only.	Water	68-73	motilin	Homo sapiens	0-7
8833615-4	1996	Total fluid intake, and tap water in particular, showed a strong inverse dose-response relationship to cancer risk among women (odds ratio (OR) for highest to lowest quartile of total fluid intake = 0.3; trend P &lt; 0.01)..	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
8617713-1	1996	The mercurial insensitive water channel (MIWC, AQP-4) is a water-selective transporter expressed at the basolateral plasma membrane of principal cells in kidney collecting duct, airway epithelium, and gastric parietal cells, as well as in astrocytes and skeletal muscle plasmalemma.	Water	26-31	LOW QUALITY PROTEIN: aquaporin-4	Cricetulus griseus	47-52
8564134-4	1996	In the auto-CPAP group, the pressure level could change within fixed limits in both directions (+2 to -4 cm H2O) of the previously determined effective pressure level (Peff).	Water	108-111	centromere protein J	Homo sapiens	12-16
8734306-1	1996	OBJECTIVES AND METHODS: The purpose of this study was to compare the effects of peptide YY (PYY) and neuropeptide Y (NPY) on VIP- and PGE2-stimulated intestinal net water flux at three different levels of the small intestine (duodenum, jejunum, ileum), by a technique of in situ closed loops in anaesthetised rats.	Water	165-170	peptide YY	Rattus norvegicus	80-90
8567681-12	1996	The density of particles on the protoplasmic face of the plasma membrane of oocytes expressing AAP1 increased approximately 5-fold above water-injected controls and corresponded to a turnover number 350 to 800 s-1.	Water	137-142	amino acid permease 1	Arabidopsis thaliana	95-99
8561506-1	1996	We have been able to demonstrate that cytochrome b4 interacts closely with cytochrome P450 in the microsomal membrane, and that substrates can serve to order the interaction: Using the water-soluble carbodiimide EDC we could crosslink cytochrome b5 and CYP2B4 in microsomes from phenobarbital-treated rabbits and cytochrome b5 and CYP1A2 in microsomes from beta-naphthoflavone-treated animals.	Water	185-190	cytochrome b5	Oryctolagus cuniculus	235-248
8561506-1	1996	We have been able to demonstrate that cytochrome b4 interacts closely with cytochrome P450 in the microsomal membrane, and that substrates can serve to order the interaction: Using the water-soluble carbodiimide EDC we could crosslink cytochrome b5 and CYP2B4 in microsomes from phenobarbital-treated rabbits and cytochrome b5 and CYP1A2 in microsomes from beta-naphthoflavone-treated animals.	Water	185-190	cytochrome b5	Oryctolagus cuniculus	313-326
8549808-2	1996	NMR studies of gamma 12 in the presence of purified GPIIb/IIIa in SDS/water solution have demonstrated the presence of two gamma 12 binding states, one of which is eliminated by GRGDSP (RGD) up to a RGD: gamma 12 ratio of 2:1.	Water	70-75	integrin subunit alpha 2b	Homo sapiens	52-57
8612303-1	1996	3,4-Dihydro-2-amino-6 methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (AG337) is a water-soluble, lipophilic inhibitor of thymidylate synthase (TS) designed using X-ray structure - based methodologies to interact at the folate cofactor binding site of the enzyme.	Water	94-99	thymidylate synthase	Mus musculus	133-153
8612303-1	1996	3,4-Dihydro-2-amino-6 methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (AG337) is a water-soluble, lipophilic inhibitor of thymidylate synthase (TS) designed using X-ray structure - based methodologies to interact at the folate cofactor binding site of the enzyme.	Water	94-99	thymidylate synthase	Mus musculus	155-157
8834861-0	1996	Ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
8599654-4	1995	The curve described by XOG/Lip versus [OG]H2O shows that the partition coefficient of OG is changing throughout the solubilization process.	Water	42-45	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	27-30
8599654-8	1995	From the onset to the end of the solubilization process (domain 3), the evolution of (XOG/Lip) with [OG]H2O can be fitted by a model corresponding to the coexistence of detergent-saturated lamellar phase with lipid-saturated mixed micelles, both in equilibrium with an aqueous phase, i.e., a three-phase domain.	Water	104-107	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	90-93
8599674-1	1995	For hydrated metmyoglobin, methemoglobin, and lysozyme powders, the freezable water fraction of between approximately 0.3-0.4 g water/g protein up to approximately 0.7-0.8 g water/g protein has been fully vitrified by cooling at rates up to approximately 1500 K min-1 and the influence of cooling rate characterized by x-ray diffractograms.	Water	78-83	hemoglobin subunit gamma 2	Homo sapiens	27-40
7797019-1	1995	BACKGROUND &amp; AIMS: It has recently been described that kappa-opioid receptor agonists inhibit antidiuretic hormone secretion and promote water excretion in humans and experimental animals.	Water	141-146	opioid receptor kappa 1	Homo sapiens	59-80
7541037-7	1995	These values correspond to 5488 +/- 883 and 5255 +/- 604 mol of water transferred from the reacting protein surfaces per mol of FXa generated.	Water	64-69	coagulation factor X	Homo sapiens	128-131
7750467-0	1995	The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat.	Water	55-60	adrenomedullin	Rattus norvegicus	30-44
7750467-2	1995	Cerebroventricular injection of AdM (22, 44, and 88 pmol) resulted in a dose-related diminution of water drinking in response to subsequent central administration of 100 pmol angiotensin II.	Water	99-104	adrenomedullin	Rattus norvegicus	32-35
7750467-3	1995	Additionally, 88 pmol AdM significantly inhibited the drinking response to overnight water deprivation and hyperosmotic challenge.	Water	85-90	adrenomedullin	Rattus norvegicus	22-25
7629313-1	1995	Atrial natriuretic peptide (ANP) is one of three structurally homologous natriuretic peptides present in heart and brain, which is thought to be involved in the regulation of water and salt intake, blood pressure, and hormone secretion.	Water	175-180	natriuretic peptide A	Rattus norvegicus	0-26
7629313-1	1995	Atrial natriuretic peptide (ANP) is one of three structurally homologous natriuretic peptides present in heart and brain, which is thought to be involved in the regulation of water and salt intake, blood pressure, and hormone secretion.	Water	175-180	natriuretic peptide A	Rattus norvegicus	28-31
7762628-1	1995	Determination of deuterium (D) concentration in tap water and urine is demonstrated to average error approximately 0.5% (coefficient of variation) using a 400-MHz nuclear magnetic resonance (NMR) instrument.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
7740582-1	1995	BACKGROUND AND PURPOSE: Atrial natriuretic peptide (ANP) and arginine vasopressin regulate brain water and electrolytes.	Water	97-102	natriuretic peptide A	Rattus norvegicus	24-50
7740582-9	1995	RESULTS: Atrial natriuretic peptide given after a 4-hour delay significantly reduced brain water and sodium 24 hours after the injury (P &lt; .05).	Water	91-96	natriuretic peptide A	Rattus norvegicus	9-35
7552242-5	1995	The reductions in MAP-2 and synaptophysin-IR were reversed by 3 days of treatment with dexamethasone (10 mg/l drinking water) or ipsapirone, a 5-HT1A agonist (1 mg/kg s.c.).	Water	119-124	synaptophysin	Rattus norvegicus	28-41
7540850-4	1995	Aquaporin 1 (AQP1), aquaporin 2 (AQP2) and the mercury-insensitive water channel (MIWC) are water-selective channel proteins, whereas the fourth, referred to as aquaporin 3 (AQP3), permits transport of urea and glycerol as well.	Water	67-72	aquaporin 4	Homo sapiens	82-86
7606450-2	1995	In control rats that were given water for drinking, the supraoptic nucleus contained a cluster of calretinin-stained cells.	Water	32-37	calbindin 2	Rattus norvegicus	98-108
7749279-0	1995	Comparison of trihalomethane in tap water with and without activated carbon adsorption during the preparation process of tap water.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
23606035-0	1995	Influence of water activity on the production of T-2 Toxin byFusarium sporotrichioides.	Water	13-18	solute carrier family 25 member 5	Homo sapiens	49-52
23606035-1	1995	The production of T-2 Toxin by two strains ofFusarium sporotrichioides at high (0.995), medium (0.970) and low (0.945) water activity (aw) was investigated.	Water	119-124	solute carrier family 25 member 5	Homo sapiens	18-21
18966240-8	1995	The proposed method was applied to the determination of tin in tap water, hair, serum samples and geological reference samples.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
7531248-1	1995	Water oxygen-17 spin relaxation was used to study hydration and dynamics of the globular proteins bovine pancreatic trypsin inhibitor (BPTI) and ubiquitin in aqueous solution.	Water	0-5	spleen trypsin inhibitor I	Bos taurus	135-139
7531248-3	1995	This difference was ascribed to the absence, in ubiquitin, of highly ordered internal water molecules, which are known to be present in BPTI and in most other globular proteins.	Water	86-91	spleen trypsin inhibitor I	Bos taurus	136-140
7531248-5	1995	The relaxation data indicate that the internal water molecules of BPTI exchange with bulk water on the time-scale 10(-8) to 10(-6) second thus lowering the recently reported upper bound on the residence time of these internal water molecules by four orders of magnitude, and implying that local unfolding occurs on the submicrosecond time-scale.	Water	47-52	spleen trypsin inhibitor I	Bos taurus	66-70
7531248-5	1995	The relaxation data indicate that the internal water molecules of BPTI exchange with bulk water on the time-scale 10(-8) to 10(-6) second thus lowering the recently reported upper bound on the residence time of these internal water molecules by four orders of magnitude, and implying that local unfolding occurs on the submicrosecond time-scale.	Water	90-95	spleen trypsin inhibitor I	Bos taurus	66-70
7531248-5	1995	The relaxation data indicate that the internal water molecules of BPTI exchange with bulk water on the time-scale 10(-8) to 10(-6) second thus lowering the recently reported upper bound on the residence time of these internal water molecules by four orders of magnitude, and implying that local unfolding occurs on the submicrosecond time-scale.	Water	90-95	spleen trypsin inhibitor I	Bos taurus	66-70
7531249-1	1995	Water deuteron (2H) spin relaxation was used to study hydrogen exchange, hydration, and protein dynamics in aqueous solutions of the globular proteins bovine pancreatic trypsin inhibitor (BPTI) and ubiquitin.	Water	0-5	spleen trypsin inhibitor I	Bos taurus	188-192
7531249-7	1995	A comparison of the water contribution to the 2H dispersion with the 17O dispersion indicates that one of the four internal water molecules of BPTI, presumably the deeply buried water molecule W122, exchanges more slowly (10(-6) to 10(-4) second) than the other three (10(-8) to 10(-6) second).	Water	20-25	spleen trypsin inhibitor I	Bos taurus	143-147
7531249-7	1995	A comparison of the water contribution to the 2H dispersion with the 17O dispersion indicates that one of the four internal water molecules of BPTI, presumably the deeply buried water molecule W122, exchanges more slowly (10(-6) to 10(-4) second) than the other three (10(-8) to 10(-6) second).	Water	124-129	spleen trypsin inhibitor I	Bos taurus	143-147
7531249-7	1995	A comparison of the water contribution to the 2H dispersion with the 17O dispersion indicates that one of the four internal water molecules of BPTI, presumably the deeply buried water molecule W122, exchanges more slowly (10(-6) to 10(-4) second) than the other three (10(-8) to 10(-6) second).	Water	124-129	spleen trypsin inhibitor I	Bos taurus	143-147
7811729-5	1995	Covalent crosslinking experiments using a water-soluble carbodiimide show that adrenodoxin crosslinks exclusively to the 30.6 kDa fragment, thus implicating the N-terminal region of adrenodoxin reductase in binding to the iron-sulfur protein.	Water	42-47	ferredoxin reductase	Bos taurus	182-203
8789076-0	1995	Reply to "comment on "absorbed energy distribution from radiofrequency electromagnetic radiation in a mammalian cell model: effect of membrane-bound water" by Liu and Cleary.	Water	149-154	ATP binding cassette subfamily A member 1	Homo sapiens	134-148
7729383-4	1995	Results from the analysis of fluoride sources showed that 61% of tap water samples had fluoride levels above the optimal level of 0.7-1.2 ppm.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
29226743-2	2017	In the crystal structure of the tetrameric fumarase, it was found that some of the active site residues S145, T147, N188 G364 and H235 had water-mediated hydrogen bonding interactions with pyromellitic acid and citrate which help to the protonation state for the conversion of fumarate to malate.	Water	139-144	fumarate hydratase	Homo sapiens	43-51
8592487-4	1995	Water deprivation increased ANP levels on the first experimental day, followed by a marked depletion in the organum vasculosum laminae terminalis, subfornical organ and the periventricular preoptic nucleus.	Water	0-5	natriuretic peptide A	Rattus norvegicus	28-31
28726524-2	2017	The compounds are highly brain permeable, selective, reversible, and competitive monoamine oxidase B (MAO-B) inhibitors with improved water-solubility and subnanomolar potency (pIC50 &gt;8.8).	Water	134-139	monoamine oxidase B	Homo sapiens	81-100
7989328-2	1994	The addition of water-soluble cosolvents in the reaction medium of type 1 soybean lipoxygenase can modify the selectivity of the enzyme in the hydroperoxide synthesis reaction.	Water	16-21	linoleate 9S-lipoxygenase-4	Glycine max	82-94
28726524-2	2017	The compounds are highly brain permeable, selective, reversible, and competitive monoamine oxidase B (MAO-B) inhibitors with improved water-solubility and subnanomolar potency (pIC50 &gt;8.8).	Water	134-139	monoamine oxidase B	Homo sapiens	102-107
28980319-1	2017	OBJECTIVES: Possible interaction of green tea beverage (GT) containing cyclodextrins and high concentration catechins, a drinking water, with P-glycoprotein (P-gp) substrates was examined in vitro and in vivo.	Water	130-135	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	158-162
7711293-3	1994	Water deprivation for 48 h resulted in decreased ANF levels and increased corticosterone concentrations.	Water	0-5	natriuretic peptide A	Rattus norvegicus	49-52
28472871-4	2017	In this study, anti-ICAM-1 antibody-conjugated liposomes were fabricated for targeted delivery of a water-insoluble LXR agonist (T0901317) to inhibit VSMC proliferation.	Water	100-105	intercellular adhesion molecule 1	Homo sapiens	20-26
7846153-5	1994	To find out if RD28 is a water channel protein, rd28 cRNA was injected into Xenopus laevis oocytes.	Water	25-30	Aquaporin-like superfamily protein	Arabidopsis thaliana	15-19
7846153-6	1994	Expression of RD28 caused a 10- to 15-fold increase in the osmotic water permeability of the oocytes, indicating that the protein creates water channels in the plasma membrane of the oocytes and is an aquaporin just like its homology gamma-TIP.	Water	67-72	Aquaporin-like superfamily protein	Arabidopsis thaliana	14-18
7846153-6	1994	Expression of RD28 caused a 10- to 15-fold increase in the osmotic water permeability of the oocytes, indicating that the protein creates water channels in the plasma membrane of the oocytes and is an aquaporin just like its homology gamma-TIP.	Water	138-143	Aquaporin-like superfamily protein	Arabidopsis thaliana	14-18
7846153-7	1994	Although RD28 has several cysteine residues, its activity is not inhibited by mercury, and in this respect it differs from gamma-TIP and all but one of the mammalian water channels that have been described.	Water	166-171	Aquaporin-like superfamily protein	Arabidopsis thaliana	9-13
29270452-1	2018	The data presented in this article were the basis for the study reported in the research articles entitled "Statistical assessment of experimental observation on the slug body length and slug translational velocity in a horizontal pipe" (Al-Kayiem et al., 2017) [1] which presents an experimental investigation of the slug velocity and slug body length for air-water tow phase flow in horizontal pipe.	Water	361-366	snail family transcriptional repressor 2	Homo sapiens	166-170
7878091-1	1994	The distribution of evoked expression of the proto-oncogene c-fos was immunohistochemically examined in the parabrachial nucleus (PBN) of water-deprived rats after free ingestion of palatable liquids, after intra-oral infusion of aversive taste solutions including various bitter substances, and after an intraperitoneal injection of LiCl.	Water	138-143	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-65
7969474-3	1994	Here we describe the crystal structure of transducin alpha.GDP activated with aluminium fluoride (Gt alpha.GDP.AIF-4.H2O) at 1.7 A, a resolution sufficient to establish the coordination geometry of the bound aluminium fluoride as well as the extensive network of direct and water-mediated interactions that stabilize it.	Water	117-120	G protein subunit alpha z	Homo sapiens	42-58
7969474-3	1994	Here we describe the crystal structure of transducin alpha.GDP activated with aluminium fluoride (Gt alpha.GDP.AIF-4.H2O) at 1.7 A, a resolution sufficient to establish the coordination geometry of the bound aluminium fluoride as well as the extensive network of direct and water-mediated interactions that stabilize it.	Water	274-279	G protein subunit alpha z	Homo sapiens	42-58
7858560-6	1994	From these results, we conclude that inhibition of NEP may exaggerate the contribution of renal kinins to the renal water-sodium metabolism and overcome the contribution of ANP on that metabolism at least in normotensive rats.	Water	116-121	membrane metallo-endopeptidase	Rattus norvegicus	51-54
7956913-4	1994	Corticosterone replacement (200 micrograms/ml in the drinking water) suppressed GFAP, but did not increase GS transcription in adrenalectomized rats.	Water	62-67	glial fibrillary acidic protein	Rattus norvegicus	80-84
7868448-3	1994	Increase in muscle water content preceded the increase of beta-glucuronidase activity.	Water	19-24	glucuronidase, beta	Rattus norvegicus	58-76
7820657-0	1994	Regional suppression by water intake of c-fos expression induced by intraventricular infusions of angiotensin II.	Water	24-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	40-45
7820657-4	1994	Allowing rats to drink water after AII infusions suppressed c-fos expression both AVP- and OXY-stained magnocellular neurons.	Water	23-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	60-65
7856835-6	1994	The cPLA2-catalyzed hydrolysis of the water-soluble substrate 7-hydroxycoumarinyl 6-heptenoate was catalyzed by cPLA2 in the absence of calcium and other lipids.	Water	38-43	phospholipase A2 group IVA	Homo sapiens	4-9
7856835-6	1994	The cPLA2-catalyzed hydrolysis of the water-soluble substrate 7-hydroxycoumarinyl 6-heptenoate was catalyzed by cPLA2 in the absence of calcium and other lipids.	Water	38-43	phospholipase A2 group IVA	Homo sapiens	112-117
7943311-0	1994	Altered expression of GLUT-1 and GLUT-3 glucose transporters in neurohypophysis of water-deprived or diabetic rats.	Water	83-88	solute carrier family 2 member 3	Rattus norvegicus	33-39
8091252-1	1994	Animal models suggest that citrate-containing compounds augment absorption of aluminum from food and tap water, causing aluminum accumulation in bone and brain despite normal renal function.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
8063828-6	1994	Functional measurements in Xenopus oocytes expressing GLIP cRNA showed a &gt; 20-fold increase in [3H]glycerol uptake compared with water-injected oocytes; glycerol uptake was inhibited 88% by diisothiocyanodisulfonic stilbene (0.2 mM) and 36% by phloretin (0.25 mM).	Water	132-137	glucagon-like peptide 1 receptor	Rattus norvegicus	54-58
8063828-9	1994	GLIP represents the first mammalian water channel homolog that selectively transports a solute other than water.	Water	36-41	glucagon-like peptide 1 receptor	Rattus norvegicus	0-4
8057362-5	1994	The activity linked H2O/OH- group in the free HCAI is replaced by the hydroxyl group of the bicarbonate anion.	Water	20-23	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	46-50
8067390-1	1994	In rabbit renal cortical collecting tubule (CCT), perfused in vitro at 38 degrees C, ATP in concentrations of 10(-7) M and greater inhibits arginine vasopressin (AVP)-stimulated osmotic water permeability (Pf).	Water	186-191	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	162-165
7953732-9	1994	Fos was induced in both SON and PVN of all water deprived rats regardless of age.	Water	43-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
7528593-4	1994	For mosr RBC a high value of Pd was associated with a low value of Ea,d (range from 15 to 21 kJ/mol), pointing to specialized channels for water diffusion incorporated in membrane proteins.	Water	139-144	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	9-12
7528593-8	1994	A correlation between the content in CHIP 28 and the relative water permeability among RBC from different vertebrate species was attempted.	Water	62-67	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	87-90
8061662-1	1994	Tap water, flushing water and drinking water including natural mineral water, artificial mineral water and distilled water have been investigated for their radon concentrations.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
8061662-2	1994	It has been found that the radon concentration in natural mineral water samples is the highest and that in tap water is the second highest, while other categories have values very near to the detection limit.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
8061662-4	1994	It is found that annual effective dose due to direct consumption of water (mineral and tap water) is far greater than that due to inhalation of radon emanated from tap water and flushing water.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	87-90
8061662-4	1994	It is found that annual effective dose due to direct consumption of water (mineral and tap water) is far greater than that due to inhalation of radon emanated from tap water and flushing water.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
8061662-4	1994	It is found that annual effective dose due to direct consumption of water (mineral and tap water) is far greater than that due to inhalation of radon emanated from tap water and flushing water.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
8061662-5	1994	Moreover, it is also shown that the annual effective doses due to inhalation of radon emanated from tap water and flushing water is negligible when compared to the total annual effective dose for indoor radon in Hong Kong.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
7765246-5	1994	Gassericin A, a highly hydrophobic bacteriocin, was slightly soluble in water, but its solubility was increased by adding alcohol and acetonitrile.	Water	72-77	gaaA	Lactobacillus gasseri	0-12
8200442-2	1994	The in vivo spin-trapping of .NO was performed by injecting into mice a metal-chelator complex, consisting of N-methyl-D-glucamine dithiocarbamate (MGD) and reduced iron (Fe2+), that binds to .NO and forms a stable, water-soluble [(MGD)2-Fe(2+)-NO] complex, and by monitoring continuously the in vivo formation of the latter complex using an S-band EPR spectrometer.	Water	216-221	spindlin 1	Mus musculus	12-16
21244888-3	1994	A contraction in 1 mM[Ca](0) is triggered by entry of only 6-10 mumo/L cell water via the sarcolemmal "L" Ca channel, resulting in the secondary release of 50-60 munol from the sarcoplasmic reticulum (SR) compartment, which contains 500 mumol in the junctional (JSR) plus corbular (CSR) components.	Water	76-81	protein tyrosine phosphatase receptor type C	Homo sapiens	103-108
8011270-1	1994	(Z)-Aib-Gly-L-Ile-L-Leu-OMe.H2O, C27H42N4O7.H2O, is a protected analogue of the C-terminal sequence of the membrane-active peptaibol antibiotic trichogin A IV.	Water	28-31	ANIB1	Homo sapiens	4-7
8011270-1	1994	(Z)-Aib-Gly-L-Ile-L-Leu-OMe.H2O, C27H42N4O7.H2O, is a protected analogue of the C-terminal sequence of the membrane-active peptaibol antibiotic trichogin A IV.	Water	44-47	ANIB1	Homo sapiens	4-7
8130269-11	1994	These results indicate SP-A and calcium limit the adsorption of surfactant cholesterol to the air-water interface.	Water	98-103	pulmonary surfactant-associated protein A	Bos taurus	23-27
8198230-8	1994	Mice receiving ethanol in the drinking water showed alterations in the CD4 CD45RC subsets and in the CD8 CD45RC subsets.	Water	39-44	CD4 antigen	Mus musculus	71-74
8198230-11	1994	But, a decrease in the percentage of CD4- CD8+ cells was observed in the thymus of mice receiving ethanol in the drinking water.	Water	122-127	CD4 antigen	Mus musculus	37-40
8188820-0	1994	Suitability of autoclaved tap water for preparation of ELISA reagents and washing buffer.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
8188820-2	1994	The performance of the assay, using autoclaved tap water (AT-ELISA) compared favourably to that of the standard assay, using ultrapure water (UP-ELISA) in detecting anti-PRV antibodies in sequential serum samples from a pig experimentally infected with PRV.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
8188820-4	1994	The results suggest that autoclaved tap water may be substituted for ultrapure water for the preparation of ELISA reagents when or where ultrapure water may not be available.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
8139144-3	1994	On the other hand, the newly described atrial natriuretic peptide (ANP) hormonal system in both humans and animals appears to play an important role in sodium and water excretion.	Water	163-168	natriuretic peptide A	Rattus norvegicus	39-65
8275481-1	1994	Water-soluble ingredients of the herbal medicine sho-saiko-to dose-dependently inhibited the proliferation of a human hepatocellular carcinoma cell line (KIM-1) and a cholangiocarcinoma cell line (KMC-1).	Water	0-5	hepatitis A virus cellular receptor 1	Homo sapiens	154-159
8140274-7	1994	Microcatheterization studies showed significant partial reversal of ANF-induced inhibition of sodium chloride and water reabsorption in the medullary collecting duct.	Water	114-119	natriuretic peptide A	Rattus norvegicus	68-71
7942281-1	1994	Hormone sensitive lipase (HSL) is an enzyme of relatively broad specificity, having the ability to hydrolyze tri-, di- and mono-acylglycerols as well as cholesterol esters and small water-soluble substrates.	Water	182-187	lipase E, hormone sensitive type	Homo sapiens	0-24
7942281-1	1994	Hormone sensitive lipase (HSL) is an enzyme of relatively broad specificity, having the ability to hydrolyze tri-, di- and mono-acylglycerols as well as cholesterol esters and small water-soluble substrates.	Water	182-187	lipase E, hormone sensitive type	Homo sapiens	26-29
7942281-7	1994	Evidence indicates that HSL has at least three functional domains which contain (a) the phosphorylation sites which control activity, (b) the active site responsible for the catalytic activity and (c) a lipid binding site responsible for anchoring the lipase at the water-lipid interface.	Water	266-271	lipase E, hormone sensitive type	Homo sapiens	24-27
7942281-10	1994	Furthermore, under appropriate conditions it is possible to digest HSL and retain activity against water-soluble substrates but with the concomitant loss of activity against triacylglycerol, implying that a lipid binding domain is lost during this procedure.	Water	99-104	lipase E, hormone sensitive type	Homo sapiens	67-70
7504987-0	1994	The human gene for water channel aquaporin 1 (AQP1) is localized on chromosome 7p15--&gt;p14.	Water	19-24	ribonuclease P/MRP subunit p14	Homo sapiens	89-92
8026715-8	1994	In the test cage hyperdipsia was suppressed, but preference for tap water was preserved.	Water	68-73	SEC14-like lipid binding 2	Rattus norvegicus	64-67
8026715-12	1994	We conclude that AMPH-induced preference for tap water over saline is unrelated to hyperdipsia but, being also induced by yohimbine, it may depend on noradrenergic mechanisms.	Water	49-54	SEC14-like lipid binding 2	Rattus norvegicus	45-48
7854091-9	1994	CPAP through a nasal mask was initiated with a 5 cm H2O pressure and high FIO2.	Water	52-55	centromere protein J	Homo sapiens	0-4
8253212-3	1993	Our data support the notion that the terminal beta 1,6-linked GlcNAc unit of GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc may interact with the reducing end GlcNAc unit intramolecularly in water solution.	Water	195-200	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	46-52
8253212-3	1993	Our data support the notion that the terminal beta 1,6-linked GlcNAc unit of GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc may interact with the reducing end GlcNAc unit intramolecularly in water solution.	Water	195-200	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	84-90
7516874-1	1993	Tert-butyl alcohol, an important commodity chemical, additive to unleaded gasoline, and contaminant of drinking water, was evaluated for toxicity and was found to enhance nephropathy in male Fischer 344 rats.	Water	112-117	telomerase reverse transcriptase	Rattus norvegicus	0-4
8680444-4	1993	In contrast, water deprivation increased binding of [125I]-CCK-8S by 128 +/- 15% in the SON and by 196% +/- 24% in the PVN, while combined food and water deprivation produced smaller increases in both nuclei (30 +/- 5% and 98 +/- 26% in SON and PVN respectively).	Water	13-18	cholecystokinin	Rattus norvegicus	59-62
8294530-1	1993	The tap water supply in Camelford, North Cornwall and environs was contaminated by aluminium and other metals in 1988.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
7692089-0	1993	Generation of a water-soluble oligomeric ectodomain of the Rous sarcoma virus envelope glycoprotein.	Water	16-21	endogenous retrovirus group K member 20	Homo sapiens	78-99
7692089-4	1993	The GPI-linked protein is quantitatively removed from the cell surface by treatment with phosphatidylinositol phospholipase C. The phosphatidylinositol phospholipase C-released, water-soluble Env glycoprotein ectodomain retains the wild-type oligomeric structure and provides a useful tool for studying the subgroup-specific binding and fusion activities of a prototypic retroviral Env glycoprotein.	Water	178-183	endogenous retrovirus group K member 20	Homo sapiens	192-195
7692089-4	1993	The GPI-linked protein is quantitatively removed from the cell surface by treatment with phosphatidylinositol phospholipase C. The phosphatidylinositol phospholipase C-released, water-soluble Env glycoprotein ectodomain retains the wild-type oligomeric structure and provides a useful tool for studying the subgroup-specific binding and fusion activities of a prototypic retroviral Env glycoprotein.	Water	178-183	endogenous retrovirus group K member 20	Homo sapiens	382-385
8250567-1	1993	The abilities of 10 hygienic hand-washing agents and tap water (containing approximately 0.5 ppm of free chlorine) to eliminate strain HM-175 of hepatitis A virus (HAV) and poliovirus (PV) type 1 (Sabin) were compared by using finger pad and whole-hand protocols with three adult volunteers.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
24198101-3	1993	These isotope ratios were found to be depleted in(206)Pb compared with a mean of 1.160 +- 0.012 for tap water in contact with lead pipes and %typical ratios of 1.17-1.19 for British lead ore deposits and coal.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
8260842-3	1993	Second, experimentally measured and previously reported ratios of chloroform concentrations in air and breath to tap-water concentration are used to evaluate the model predictions.	Water	117-122	nuclear RNA export factor 1	Homo sapiens	113-116
8260842-5	1993	This analysis indicates that the ratio of chloroform dermally absorbed in the shower relative to tap-water concentration is between 0.25 and 0.66 mg per mg/L and that the effective permeability of the skin during a 10-min.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
7909746-4	1993	Administration of 4PPm Na2SeO3 in water 2 weeks before i.p injection of DEN (200 ng/kg bw) for 8 weeks reduced the PKC-alpha gene overexpression in preneoplastic liver and the formation of hyperplastic foci, alpha-GT-altered foci and preneoplastic lesions.	Water	34-39	protein kinase C, alpha	Rattus norvegicus	115-124
8335721-8	1993	With 200 ml of tap water, the recoveries for most of the examined pesticides were ca.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
8512325-1	1993	Nonhistone chromosomal protein HMG-17 from porcine thymus has been isolated by extraction in boiling water, gel filtration and HPLC, and its complete primary structure (89 residues) has been determined.	Water	101-106	high mobility group nucleosomal binding domain 2	Homo sapiens	0-37
8261139-8	1993	Upon reperfusion with normal artificial sea water, [Ca2+]i is elevated at the tip of the cut axon and a membrane seal is formed.	Water	44-49	carbonic anhydrase 2	Homo sapiens	52-55
8101198-3	1993	The source of infection was contaminated tap water used for irrigation of the burns, as part of the first-aid treatment which the patients received when entering the hospital.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
8454341-11	1993	In ligand blots, p42-CR3 bound C3(H2O), C3b, and iC3b but not C3d; p55-CR3 clearly reacted with C3(H2O) and weakly reacted with C3b and iC3b.	Water	34-37	erythrocyte membrane protein band 4.2	Homo sapiens	17-20
8492301-3	1993	Epinephrine was oxidized rapidly in sodium chloride prepared with tap water (1.20 +/- 0.12 nmoles/min) or in deionized water (0.40 +/- 0.80 nmoles/min), but this oxidation was prevented by the addition of Desferal, a potent metal chelating agent.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
27519332-6	1995	The medication was administered after an overnight fast (10 hours) with 200ml of tap water.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
8557826-5	1995	Increase of ICP and brain water content were significantly inhibited (P &lt;0.05) by intravenous treatment with ICAM-1 mAb (TM-8, 1 mg/kg).	Water	26-31	intercellular adhesion molecule 1	Rattus norvegicus	112-118
8907431-2	1995	This study was designed to assess the effects of CPAP through face mask with 15 cm H2O on left ventricular performance in AMI patients, using equilibrium radionuclide angiocardiography (ERA).	Water	83-86	centromere protein J	Homo sapiens	49-53
8609195-0	1995	Increased sensitivity of poliovirus detection in tap water concentrates by reverse transcriptase-polymerase chain reaction.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
8609195-1	1995	This study developed a methodology to increase the sensitivity of enteric virus detection in tap water concentrates.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
8609195-8	1995	PCI extraction was found to be sufficient to remove inhibitory substances for reverse transcriptase (RT)-seminested PCR with a sensitivity of 0.2 plaque-forming units/10 microliters (0.2 PFU/l tap water).	Water	197-202	nuclear RNA export factor 1	Homo sapiens	193-196
8845473-1	1995	Etoposide phosphate (EP) is a water-soluble derivative of etoposide (VP-16), a semisynthetic podophyllotoxin which is useful in the treatment of a wide variety of hematological malignancies and solid tumors.	Water	30-35	host cell factor C1	Homo sapiens	69-74
7589267-3	1995	A case-control study showed a significant association between illness and consumption of tap water supplied by a particular water company, as well as a dose response effect.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
7559426-7	1995	Expression of hMIWC cRNAs in Xenopus oocytes increased osmotic water permeability by 10-20-fold in a mercurial insensitive manner.	Water	63-68	aquaporin 4	Homo sapiens	14-19
8588813-4	1995	The expression for the reaction rate (for substrates AA1 and AA2) is shown to be v = k[Boc-AA1-OTfs][H-AA2-NH2]0.5 for both water and DMF, i.e., the reaction is not a simple second-order reaction.	Water	124-129	AA2	Homo sapiens	61-64
8588813-4	1995	The expression for the reaction rate (for substrates AA1 and AA2) is shown to be v = k[Boc-AA1-OTfs][H-AA2-NH2]0.5 for both water and DMF, i.e., the reaction is not a simple second-order reaction.	Water	124-129	AA2	Homo sapiens	103-106
7639514-4	1995	We found that VP-16 is an effective scavenger of peroxyl radicals as judged by its ability to inhibit a water-soluble azo-initiator, 2,2"-azobis(2-amidinopropane)dihydrochloride (AAPH)-induced (i) chemiluminescence (oxidation) of luminol, (ii) fluorescence decay (oxidation) of cis-parinaric acid incorporated in SR membranes, and (iii) peroxidation of SR membrane lipids.	Water	104-109	host cell factor C1	Homo sapiens	14-19
7586106-7	1995	Stepwise reduction of nasal CPAP determined the minimally effective CPAP to prevent snoring to be 5.1 +/- 2.1 cm H2O.	Water	113-116	centromere protein J	Homo sapiens	28-32
7586106-7	1995	Stepwise reduction of nasal CPAP determined the minimally effective CPAP to prevent snoring to be 5.1 +/- 2.1 cm H2O.	Water	113-116	centromere protein J	Homo sapiens	68-72
8567168-1	1995	The dissociation of glyceraldehyde-3-phosphate dehydrogenase (GAPD) from pig muscle in water solutions (0.1 M phosphate, pH 7) at increased urea concentrations was studied by means of frontal-gel chromatography, intrinsic (TRP) fluorescence, differential absorption spectroscopy and selective chemical modification at TRP0193.	Water	87-92	glyceraldehyde-3-phosphate dehydrogenase	Sus scrofa	20-60
8567168-1	1995	The dissociation of glyceraldehyde-3-phosphate dehydrogenase (GAPD) from pig muscle in water solutions (0.1 M phosphate, pH 7) at increased urea concentrations was studied by means of frontal-gel chromatography, intrinsic (TRP) fluorescence, differential absorption spectroscopy and selective chemical modification at TRP0193.	Water	87-92	glyceraldehyde-3-phosphate dehydrogenase	Sus scrofa	62-66
7623110-2	1995	In rats that performed a well-learned nose-poke response for water reward, c-fos mRNA levels were broadly increased, relative to values in home cage-control rats, in visual cortex, superior colliculus, olfactory bulb, and, to comparable levels, regions CA3 and CA1 of hippocampus; hybridization was not increased in the dentate gyrus.	Water	61-66	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
7623110-3	1995	In rats first trained on the nose-poke behavior and then required to discriminate between two odors for water reward, the increase in c-fos mRNA was generally not as great and was more regionally differentiated.	Water	104-109	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	134-139
7543685-0	1995	Somatostatin in a water-restricted environment: fluorescence and circular dichroism study in AOT reverse micelles.	Water	18-23	somatostatin	Homo sapiens	0-12
7543685-1	1995	Steady-state and time-resolved fluorescence emission from the single tryptophan residue of somatostatin, and the kinetics of quenching of this emission, were studied in aqueous solution and in reverse micelles of sodium bis (2-ethylhexyl) sulfosuccinate (AOT)/water/isooctane, a system that mimics the water-membrane interface well.	Water	260-265	somatostatin	Homo sapiens	91-103
7543685-1	1995	Steady-state and time-resolved fluorescence emission from the single tryptophan residue of somatostatin, and the kinetics of quenching of this emission, were studied in aqueous solution and in reverse micelles of sodium bis (2-ethylhexyl) sulfosuccinate (AOT)/water/isooctane, a system that mimics the water-membrane interface well.	Water	302-307	somatostatin	Homo sapiens	91-103
7480361-4	1995	The receptors or binding sites which predominantly acted by each water extract are listed as follows: Chaihu: D2, 5-HT1A, GABA; Chuanxiong: GABA, 5-HT1A; Danggui: GABA, 5-HT1A; Danshen: BDZ; Duhuo: GABA, 5-HT1A, D2, D1; Hangqin: BDZ, D1, 5-HT1A; Qinjiao: GABA, BDZ, 5-HT1A, D2; Shengma: 5-HT1A; Suanzaoren: 5-HT1A, 5-HT2, GABA; Yangjihua: M1, 5-HT1A, 5-HT2.	Water	65-70	immunoglobulin heavy diversity 2-15	Homo sapiens	274-293
7552319-1	1995	Atrial natriuretic peptides (ANP) are a family of humoral compounds released from the heart atria and involved in water and salt homeostasis.	Water	114-119	natriuretic peptide A	Rattus norvegicus	29-32
10607188-7	1995	At a CPAP of 10 cm H2O and above, as well as at BiPAP of 10/5 or higher, there was a decrease in cardiac output (CO) and cardiac index (CI).	Water	19-22	centromere protein J	Homo sapiens	5-9
7651120-2	1995	Longitudinal water proton relaxation rates of methemoglobin solutions show a strong dependence on temperature and pH.	Water	13-18	hemoglobin subunit gamma 2	Homo sapiens	46-59
7774632-2	1995	EAU induced with interphotoreceptor retinoid-binding protein (IRBP), another retinal autoantigen, can also be suppressed by oral administration of IRBP.	Water	0-3	retinol binding protein 3	Rattus norvegicus	17-60
7774632-2	1995	EAU induced with interphotoreceptor retinoid-binding protein (IRBP), another retinal autoantigen, can also be suppressed by oral administration of IRBP.	Water	0-3	retinol binding protein 3	Rattus norvegicus	62-66
7774632-2	1995	EAU induced with interphotoreceptor retinoid-binding protein (IRBP), another retinal autoantigen, can also be suppressed by oral administration of IRBP.	Water	0-3	retinol binding protein 3	Rattus norvegicus	147-151
7657557-1	1995	The mRNA for rat liver serine dehydratase, a gluconeogenic enzyme, exhibits a circadian rhythm with a maximum at the onset of darkness marking the end of the fasting period and a minimum at the onset of light that marks the end of the feeding period, when rats have free access to food and water.	Water	290-295	serine dehydratase	Rattus norvegicus	23-41
7751909-5	1995	Changes in the levels of membrane-associated PKC, as assayed by quantitative autoradiography of the specific binding of 3H-phorbol-12,13-dibutyrate (3H-PDBu) in spinal cord sections, were assessed in rats after noxious chemical (50 microliters of 5.0% formalin) and noxious thermal (90 sec immersion in water at 55 degrees C) stimulation.	Water	303-308	protein kinase C, gamma	Rattus norvegicus	45-48
7672067-0	1995	Risk factors for hepatitis A infection in France: drinking tap water may be of importance.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
7672067-5	1995	Multivariate analysis found that high level of seroprevalence was also associated with tap water consumption (odd ratio (OR) = 1.56; p &lt; 0.04), overseas travels (OR = 2.26; p &lt; 0.001) and was higher for recruits reporting an history of clinical jaundice (OR = 2.27; p &lt; 0.01).	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
7672067-6	1995	Together with more anticipated factors, tap water consumption may be of importance in France and this study points out the potential part taken by chlorinated water.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
7672067-6	1995	Together with more anticipated factors, tap water consumption may be of importance in France and this study points out the potential part taken by chlorinated water.	Water	159-164	nuclear RNA export factor 1	Homo sapiens	40-43
7786518-1	1995	In the absence of the potentially confounding influence of vasopressin in hypertension, the effects of atrial natriuretic peptide (ANP) on arterial blood pressure and renal handling of water and sodium were assessed from comparison of responses to intravenous ANP infusion in anaesthetized vasopressin-deficient New Zealand genetically hypertensive (DI/H) rats and their normotensive substrain (DI/N).	Water	185-190	natriuretic peptide A	Rattus norvegicus	103-129
7753770-2	1995	CPAP was applied at 10 cm H2O and 15 cm H2O, BIPAP at 10/0 cm H2O and 15/10 cm H2O.	Water	26-29	centromere protein J	Homo sapiens	0-4
7753770-2	1995	CPAP was applied at 10 cm H2O and 15 cm H2O, BIPAP at 10/0 cm H2O and 15/10 cm H2O.	Water	40-43	centromere protein J	Homo sapiens	0-4
7753770-2	1995	CPAP was applied at 10 cm H2O and 15 cm H2O, BIPAP at 10/0 cm H2O and 15/10 cm H2O.	Water	40-43	centromere protein J	Homo sapiens	0-4
7753770-2	1995	CPAP was applied at 10 cm H2O and 15 cm H2O, BIPAP at 10/0 cm H2O and 15/10 cm H2O.	Water	40-43	centromere protein J	Homo sapiens	0-4
7753902-0	1995	Cholecystokinin reduces ingestive taste reactivity responses to water in fluid-replete but not fluid-deprived rats.	Water	64-69	cholecystokinin	Rattus norvegicus	0-15
7753902-1	1995	The effects of hydrational factors on the ability of cholecystokinin (CCK) to alter taste reactivity responses to intraoral water infusions was assessed in fluid-replete and fluid-deprived rats.	Water	124-129	cholecystokinin	Rattus norvegicus	53-68
7753902-1	1995	The effects of hydrational factors on the ability of cholecystokinin (CCK) to alter taste reactivity responses to intraoral water infusions was assessed in fluid-replete and fluid-deprived rats.	Water	124-129	cholecystokinin	Rattus norvegicus	70-73
7753902-4	1995	Exogenous administration of CCK was found to produce a significant decrease in the frequency of ingestive responses accompanied by a significant increase in passive drip during oral water infusions in fluid-replete rats.	Water	182-187	cholecystokinin	Rattus norvegicus	28-31
7753902-6	1995	These results demonstrate that the rat"s state of hydration interacts with the ability of CCK to alter taste reactivity responses to intraoral water infusions.	Water	143-148	cholecystokinin	Rattus norvegicus	90-93
7857973-5	1995	Circular dichroism showed that both forms of SP-C exhibit similar secondary structures at the air/water interface.	Water	98-103	surfactant protein C	Canis lupus familiaris	45-49
7864076-4	1995	The ANG II-stimulated release of the water-soluble metabolites of PC breakdown (phosphorylcholine and choline) was blocked by ANF and SNP.	Water	37-42	natriuretic peptide A	Rattus norvegicus	126-129
7696562-0	1995	The distribution of water in arterial elastin: effects of mechanical stress, osmotic pressure, and temperature.	Water	20-25	elastin	Homo sapiens	38-45
7696562-1	1995	Using gravimetric and radiotracer techniques, we investigated the effects of mechanical stress, osmotic pressure, and temperature on the volumes of the intra- and extrafibrillar water spaces in arterial elastin.	Water	178-183	elastin	Homo sapiens	203-210
7696562-7	1995	Water flux across elastin membranes, corrected for changes in viscosity, and specific hydraulic conductivity both increased as a result of temperature-induced contraction.	Water	0-5	elastin	Homo sapiens	18-25
25121193-0	1995	Environmental Medicine: Integrating a Missing Element into Medical Education People are increasingly concerned about potential environmental health hazards and often ask their physicians questions such as: "Is the tap water safe to drink?"	Water	218-223	nuclear RNA export factor 1	Homo sapiens	214-217
7754864-1	1995	The effects of centrally administered atrial natriuretic peptide (ANP) on the brain water and electrolyte contents were investigated in a rodent subarachnoid haemorrhage (SAH) model.	Water	84-89	natriuretic peptide A	Rattus norvegicus	38-64
7666747-3	1995	About 250 ml of tap water was administered per os into the airways of severely ill and comatose patients, and death occurred about one hour later.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
8559484-1	1995	Delta aminolaevulinic acid dehydratase (ALA-D) who assayed in 66 patients with end-stage renal failure who live in a region where there is a high risk of lead poisoning from drinking water (Vosges mountains).	Water	183-188	aminolevulinate dehydratase	Homo sapiens	40-45
7899096-3	1995	The average daily fluoride intake per kilogram body weight from optimally fluoridated tap water was highest (0.080 mg/kg/d) from 7 to 9 months of age, and declined linearly to 0.034 mg/kg/d at 12.5 to 13 years of age.	Water	90-95	nuclear RNA export factor 1	Homo sapiens	86-89
7792794-1	1995	It has been suggested that endogenous substances (known as ouabain-like factors, OLF), secreted from the central nervous system in response to salt and water retention, inhibit the cell membrane Na+/K+ pump in the renal tubules and reduce sodium reabsorption.	Water	152-157	transmembrane O-mannosyltransferase targeting cadherins 1	Homo sapiens	81-84
7676390-4	1995	Sucking water through a straw and swallowing produced similar functional patterns to thumb sucking: strong lip and mentalis activity but comparatively low buccinator activity.	Water	8-13	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	107-110
7528536-3	1994	A novel protocol has been developed that enables the site-specific (N-terminus) attachment of hydrophobic peptides to a water-soluble carrier protein [bovine pancreatic trypsin inhibitor (BPTI)] using a heterobifunctional crosslinker (SPDP).	Water	120-125	spleen trypsin inhibitor I	Bos taurus	188-192
7991577-1	1994	Results obtained in our laboratories have provided evidence for the participation of the hypothalamic atrial natriuretic peptide (ANP) neuronal system in the regulation of water and electrolyte homeostasis.	Water	172-177	natriuretic peptide A	Rattus norvegicus	102-128
7991577-1	1994	Results obtained in our laboratories have provided evidence for the participation of the hypothalamic atrial natriuretic peptide (ANP) neuronal system in the regulation of water and electrolyte homeostasis.	Water	172-177	natriuretic peptide A	Rattus norvegicus	130-133
7991577-10	1994	When water-loaded, DRN-lesioned and PCPA-injected animals showed diminished excretion of sodium, accompanied by a decrease in basal plasma ANP concentrations, and blockade of the increase in plasma ANP, which followed blood volume expansion by intraatrial injection of hypertonic saline.	Water	5-10	natriuretic peptide A	Rattus norvegicus	139-142
7991577-10	1994	When water-loaded, DRN-lesioned and PCPA-injected animals showed diminished excretion of sodium, accompanied by a decrease in basal plasma ANP concentrations, and blockade of the increase in plasma ANP, which followed blood volume expansion by intraatrial injection of hypertonic saline.	Water	5-10	natriuretic peptide A	Rattus norvegicus	198-201
7991577-11	1994	The results are interpreted to mean that ascending stimulatory serotoninergic input into the ANP neuronal system in the AV3V region produces a tonic stimulation of ANP release, which augments sodium excretion and inhibits water intake.	Water	222-227	natriuretic peptide A	Rattus norvegicus	93-96
7991577-11	1994	The results are interpreted to mean that ascending stimulatory serotoninergic input into the ANP neuronal system in the AV3V region produces a tonic stimulation of ANP release, which augments sodium excretion and inhibits water intake.	Water	222-227	natriuretic peptide A	Rattus norvegicus	164-167
7990707-11	1994	ANF and BNP but not CNP act on mTAL to control water excretion.	Water	47-52	natriuretic peptide A	Rattus norvegicus	0-3
7716056-4	1994	Taking into account two following facts: 1) no evidence of renal calculi when the patient was outside her own house and 2) very high concentration of calcium in her home tap water, the role of environmental factors in the pathogenesis of nephrolithiasis in presented patient is very likely.	Water	174-179	nuclear RNA export factor 1	Homo sapiens	170-173
7850393-0	1994	Mutagenic and carcinogenic risk of oxygen containing chlorinated C-3 hydrocarbons: putative secondary products of C-3 chlorohydrocarbons and chlorination of water.	Water	157-162	complement C3	Homo sapiens	65-68
7850393-1	1994	Oxygen containing C-3 chlorohydrocarbons are secondary products of C-3 chlorohydrocarbons formed during oxidation at air, in the metabolism of pesticides and by chlorination of drinking water.	Water	186-191	complement C3	Homo sapiens	18-21
7850393-1	1994	Oxygen containing C-3 chlorohydrocarbons are secondary products of C-3 chlorohydrocarbons formed during oxidation at air, in the metabolism of pesticides and by chlorination of drinking water.	Water	186-191	complement C3	Homo sapiens	67-70
7822199-11	1994	Plain tap water is used without additives.	Water	10-15	nuclear RNA export factor 1	Homo sapiens	6-9
7968167-4	1994	Each participant produced 15 swallows of 15 mL of tap water both normally and with a 12-mm bite block placed between the molars.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
7859070-3	1994	Thus, in terms of number of cells, haemorrhage was significantly more potent than water deprivation in inducing Fos immunoreactivity in either type of neuron in the supraoptic, paraventricular and anterior commissural nuclei.	Water	82-87	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-115
7859070-4	1994	However, the Fos reaction of vasopressin cells in response to either stimulus was greater than that of oxytocin cells in the supraoptic and paraventricular nuclei, and in the perifornical posterior nucleus and nucleus circularis in response to water deprivation.	Water	244-249	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-16
7859070-6	1994	Finally, our analyses clearly indicated that Fos synthesis in either type of magnocellular neuron was closely linked to the reproductive state of the animal since after haemorrhage or water deprivation, the number of Fos-positive oxytocin cells in the supraoptic nucleus and Fos-positive vasopressin cells in the paraventricular nucleus was significantly less in lactating than in virgin rats.	Water	184-189	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-48
7882063-6	1994	After the substitution of ammonium chloride by drinking water, the return of the increased GAD activity to previous normal values lasted 7 days, whilst apparent normalization of the weight of experimental animals reoccurred on the first day.	Water	56-61	glutamate-ammonia ligase	Rattus norvegicus	91-94
7875942-2	1994	TTR 10-20, TTR 105-115 as well as a substituted analogue, (TTR 105-115Met111) all formed amyloid-like fibrils readily in 20-30% acetonitrile/water at room temperature.	Water	141-146	transthyretin	Homo sapiens	0-3
7875942-2	1994	TTR 10-20, TTR 105-115 as well as a substituted analogue, (TTR 105-115Met111) all formed amyloid-like fibrils readily in 20-30% acetonitrile/water at room temperature.	Water	141-146	transthyretin	Homo sapiens	11-14
7875942-2	1994	TTR 10-20, TTR 105-115 as well as a substituted analogue, (TTR 105-115Met111) all formed amyloid-like fibrils readily in 20-30% acetonitrile/water at room temperature.	Water	141-146	transthyretin	Homo sapiens	11-14
7765392-2	1994	Catechol 2,3-dioxygenase encoded by phe B showed similar substrate specificity to that of xyl E. However, Phe B has much smaller Km values than Xyl E, indicating that Phe B is useful for treatment of low concentrations of catechol derivatives in waste water.	Water	252-257	catechol 2,3-dioxygenase	Pseudomonas putida	0-24
7816556-8	1994	Water content thus contributed to muscle damage by preceding the increase in beta-glucuronidase activity.	Water	0-5	glucuronidase, beta	Rattus norvegicus	77-95
18966134-8	1994	Tap water conductivity measurements were made using CaCl(2) reference solution.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
7820634-1	1994	Opioid receptor subtype antagonists differentially alter different types of water intake such that mu2 receptors modulate deprivation-induced water intake, kappa receptors modulate hypertonic saline-induced water intake, and mu2, delta1 and kappa receptors modulate water intake following Angiotensin II (ANG II).	Water	76-81	adaptor related protein complex 2 subunit mu 1	Rattus norvegicus	99-102
18618844-1	1994	The mechanism of extraction of rat cytochrome b(5) from water into a sodium dioctylsulfosuccinate (AOT) micellar organic phase was studied using protein engineering of surface charged residues.	Water	56-61	cytochrome b5 type A	Rattus norvegicus	35-50
8082351-5	1994	On the first night, the patients were untreated; on the second night, both groups received applied nasal CPAP at 8 cm H2O pressure.	Water	118-121	centromere protein J	Homo sapiens	105-109
7982096-8	1994	The data are discussed in terms of access of ACE inhibitors to the brain, and interactions with structures involved in Ang-related water intake.	Water	131-136	angiogenin	Rattus norvegicus	119-122
7982066-4	1994	In water-replete rats, Fos-IR was absent or very low in these regions.	Water	3-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-26
18966063-7	1994	The method has been applied to the analysis of Cr(III) in tap water.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
8085144-3	1994	Tap water lead levels at various locations in the city were &lt; 5 micrograms/l.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
7990722-5	1994	In this study, the water-soluble compound endothelin-1, when applied topically, caused dose-dependent vasoconstriction of all microvessels but had no effect when perfused intraluminally.	Water	19-24	endothelin 1	Bos taurus	42-54
8023364-9	1994	In addition, treatment with RP3 significantly attenuated the postischemic increase in brain water content at 24 hours after reperfusion.	Water	92-97	microtubule-associated protein, RP/EB family, member 3	Rattus norvegicus	28-31
7943927-6	1994	During the epidemic period, the hospital"s chlorinated well-water system malfunctioned; chlorine levels were undetectable and tap water samples contained elevated microbial levels, including total and fecal coliform bacteria.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
8436646-5	1993	For treatment of hyperhidrosis, tap water iontophoresis was applied using a modified technique with special electrodes.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
8417970-3	1993	The rise of rotator content at a urea concentration C3 &gt; or = C3* when the bulk water is practically exhausted is suggested as a main driving force of protein unfolding.	Water	83-88	complement C3	Homo sapiens	65-68
8312955-4	1993	The case-control study revealed an association between cholera and drinking unboiled tap water (OR = 7.2; 95% CI = 1.6-32.2), and also between cholera and limited availability of water (&lt; 1,400 liters per week) within the household (OR = 3.6; 95% CI = 0.8-16.4).	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
29270452-1	2018	The data presented in this article were the basis for the study reported in the research articles entitled "Statistical assessment of experimental observation on the slug body length and slug translational velocity in a horizontal pipe" (Al-Kayiem et al., 2017) [1] which presents an experimental investigation of the slug velocity and slug body length for air-water tow phase flow in horizontal pipe.	Water	361-366	snail family transcriptional repressor 2	Homo sapiens	187-191
8482015-5	1993	In general, the levels of both HSP71 and HSP25 were found to be tissue dependent, with higher levels found in tissues such as stomach, intestine, colon and bladder, tissues which are exposed to toxic environmental or metabolic products, and which may concentrate these substances by water resorption and/or be exposed to them for longer periods.	Water	283-288	heat shock protein 1	Mus musculus	41-46
8004320-6	1994	N-CPAP (mc) and face mask CPAP (f-CPAP) resulted in significant dose-dependent decreases of SV-24 +/- 5 ml (21%) and 33 +/- 5 ml (28%), respectively--from baseline to 20 cm H2O (p &lt; 0.05).	Water	173-176	centromere protein J	Homo sapiens	2-6
29270452-1	2018	The data presented in this article were the basis for the study reported in the research articles entitled "Statistical assessment of experimental observation on the slug body length and slug translational velocity in a horizontal pipe" (Al-Kayiem et al., 2017) [1] which presents an experimental investigation of the slug velocity and slug body length for air-water tow phase flow in horizontal pipe.	Water	361-366	snail family transcriptional repressor 2	Homo sapiens	187-191
8011926-3	1994	This differs from earlier results where a discontinuous central filament structure was seen after spreading proteoglycan aggregates at a water/air interphase.	Water	137-142	hyaluronan and proteoglycan link protein 1	Homo sapiens	108-120
29270452-1	2018	The data presented in this article were the basis for the study reported in the research articles entitled "Statistical assessment of experimental observation on the slug body length and slug translational velocity in a horizontal pipe" (Al-Kayiem et al., 2017) [1] which presents an experimental investigation of the slug velocity and slug body length for air-water tow phase flow in horizontal pipe.	Water	361-366	snail family transcriptional repressor 2	Homo sapiens	187-191
28942635-4	2017	Autoclaved Elk River sediment slurries sorbed 17.5% of cis-4-MCHM and 31% of trans-4-MCHM from water during the 2-week experiment.	Water	95-100	potassium voltage-gated channel subfamily H member 8	Homo sapiens	11-14
8064691-3	1994	If a water compartment of 59% is assumed, the total volume of mouse spermatozoa is 73.4 micron3.	Water	5-10	interferon alpha	Mus musculus	0-4
8380375-9	1993	Despite similar levels of pituitary POMC mRNA, pituitary ACTH content was reduced in water-deprived rats, suggesting a posttranscriptional inhibition of POMC synthesis or processing.	Water	85-90	proopiomelanocortin	Rattus norvegicus	153-157
8253233-3	1993	Trophozoites of PHL/530 adhered in greater numbers to type I lenses (61.4% poly[2-hydroxyethyl methacrylate-38.6% water), with no differences between type II (30% lidofilcon A-70% water), III (55% bufilcon A-45% water) and IV lenses (42% etafilcon A-58% water).	Water	180-185	BCR activator of RhoGEF and GTPase	Homo sapiens	16-19
29105032-4	2017	The results revealed that dissociation into water molecule(s) and proton(s) complements H3O+ ion(s) adsorbtion.	Water	44-49	H3 clustered histone 15	Homo sapiens	88-91
7915340-8	1994	In glomeruli, hyperosmolality of 490 mOsm/kg.H2O using NaCl also reduced ANP-stimulated cGMP generation, and hypertonicity of 690 mOsm/kg.H2O using NaCl further reduced it.	Water	138-141	natriuretic peptide A	Rattus norvegicus	73-76
7915292-3	1994	Discrepancies between recommended and local practice included lack of specification of detergent/cleaning agent (57%), inadequate contact time for chemical disinfection (40%) and the use of tap water rather than sterile water for rinsing the disinfected bronchoscope (39.7%).	Water	194-199	nuclear RNA export factor 1	Homo sapiens	190-193
8514470-3	1993	The three sources of drinking water in these localities were tap, handpump and well and the prevalence of urinary stone disease in relation with the source of drinking water was 548.3, 303.4 and 189.9/1,00,000 population, respectively.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	61-64
28870812-11	2017	The results may suggest that surgery-induced hypothyroidism increases GLP-1, the actions of which may in part be responsible for the reduction in water intake, appetite and hepatic steatosis.	Water	146-151	glucagon	Rattus norvegicus	70-75
8514470-5	1993	The tap water was softest with highest prevalence.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
8321362-1	1993	Compared to healthy humans in most patients with cirrhosis and renal sodium and water retention, effects of atrial natriuretic peptide (ANP) on sodium and water excretion are reduced.	Water	155-160	natriuretic peptide A	Rattus norvegicus	108-134
8036126-1	1994	Earlier data showed that subjects presented with two samples of distilled water and one of tap water were significantly more consistent in choosing the tap water as preferred than in identifying it as the odd sample in the set.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	152-155
8036126-1	1994	Earlier data showed that subjects presented with two samples of distilled water and one of tap water were significantly more consistent in choosing the tap water as preferred than in identifying it as the odd sample in the set.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
8036126-1	1994	Earlier data showed that subjects presented with two samples of distilled water and one of tap water were significantly more consistent in choosing the tap water as preferred than in identifying it as the odd sample in the set.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	152-155
8036126-1	1994	Earlier data showed that subjects presented with two samples of distilled water and one of tap water were significantly more consistent in choosing the tap water as preferred than in identifying it as the odd sample in the set.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
8036126-1	1994	Earlier data showed that subjects presented with two samples of distilled water and one of tap water were significantly more consistent in choosing the tap water as preferred than in identifying it as the odd sample in the set.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	152-155
29109472-6	2017	Specifically, aquaporin 5 and parvalbumin, which are correlated with water transport and intracellular Ca2+ signal transduction, were verified to exhibit differences in protein abundance.	Water	69-74	aquaporin 5	Rattus norvegicus	14-25
8162991-2	1994	Two of these, SP-A and SP-D, are large and water-soluble, while SP-B and SP-C are small and very hydrophobic.	Water	43-48	surfactant protein D	Homo sapiens	23-27
8397424-1	1993	Spin lattice relaxation times of water protons have been reported to correlate with the water contents of malignant as well as benign tissues.	Water	33-38	spindlin 1	Homo sapiens	0-4
7511249-1	1994	As atrial natriuretic factor (ANF) is intimately involved in water and electrolyte homeostasis, dose-response studies were performed in the parotid as well as submaxillary glands of the rat with increasing doses of the atrial peptide to investigate its possible role as a sialogogic agent.	Water	61-66	natriuretic peptide A	Rattus norvegicus	3-28
8397424-1	1993	Spin lattice relaxation times of water protons have been reported to correlate with the water contents of malignant as well as benign tissues.	Water	88-93	spindlin 1	Homo sapiens	0-4
29109472-6	2017	Specifically, aquaporin 5 and parvalbumin, which are correlated with water transport and intracellular Ca2+ signal transduction, were verified to exhibit differences in protein abundance.	Water	69-74	parvalbumin	Rattus norvegicus	30-41
28833692-14	2017	Ang-(1-7) did not change water and salt intake in control rats; however, Ang-(1-7) increased water intake after WD and SL, with no change in salt intake.	Water	93-98	angiogenin	Rattus norvegicus	73-81
8219899-7	1993	Filtration of tap water through carbon filters markedly reduced mutagenic activity of tested water extracts, whereas ceramic filters were more efficient in depleting of DNA interstrand cross-linking contaminants.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
8305467-14	1994	Experiments on retinoic acid formation under 18O2 or H2(18)O demonstrated that the oxygen of water was incorporated into retinoic acid by the retinal oxidase, but not molecular oxygen.	Water	93-98	aldehyde oxidase 1	Oryctolagus cuniculus	142-157
31966420-5	2017	We demonstrated that Abeta peptide and H2O2 treatment could result in the translocation of RXRalpha and Nur77 from the nucleus to the mitochondria, and the ligand of RXR, 9-cis-RA, treatment can block the above phenomenon.	Water	39-43	retinoid X receptor alpha	Homo sapiens	91-94
8132983-8	1993	M xenopi isolation was attributed to exposure of clinical specimens to tap water, including rinsing of bronchoscopes with tap water after disinfection, irrigation with tap water during colonoscopy, gargling with tap water before sputum collection, and collecting urine in recently rinsed bedpans.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
1334431-2	1992	We found 16 equivalent water sites conserved in trypsin/ogen, chymotrypsin/ogen, elastase, kallikrein, thrombin, rat tonin and rat mast cell protease, and 5 additional water sites in enzymes which share the primary specificity of trypsin.	Water	23-28	kallikrein 1-related peptidase C2	Rattus norvegicus	117-122
29195449-1	2017	Machine learning classifiers are shown to outperform conventional matched field processing for a deep water (600 m depth) ocean acoustic-based ship range estimation problem in the Santa Barbara Channel Experiment when limited environmental information is known.	Water	102-107	inositol polyphosphate-5-phosphatase D	Homo sapiens	143-147
1333795-1	1992	The gene coding for the water-soluble domain of the outer mitochondrial membrane cytochrome b5 (OM cytochrome b5) from rat liver has been synthetized and expressed in Escherichia coli.	Water	24-29	cytochrome b5 type A	Rattus norvegicus	81-94
1333795-1	1992	The gene coding for the water-soluble domain of the outer mitochondrial membrane cytochrome b5 (OM cytochrome b5) from rat liver has been synthetized and expressed in Escherichia coli.	Water	24-29	cytochrome b5 type A	Rattus norvegicus	99-112
8281451-3	1993	When infused chronically at a high dose (12 micrograms/day) into the lateral ventricle, BDNF caused a behavioral syndrome of reduced food and water intake, body weight loss, and locomotor hyperactivity in comparison to NGF- and vehicle-infused graft recipients.	Water	142-147	brain-derived neurotrophic factor	Rattus norvegicus	88-92
28823086-3	2017	Upon gradual addition of Al3+ and/or Hg2+ to the solution of HL significant enhancement of fluorescence intensity is observed at 564 nm in MeCN:H2O (1:5, v/v) medium.	Water	144-147	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	37-40
8274523-9	1993	When GALA, a water soluble, membrane-destabilizing peptide, is covalently attached to the dendrimer via a disulfide linkage, transfection efficiency of the 1:1 complex is increased by 2-3 orders of magnitude.	Water	13-18	galactosidase alpha	Homo sapiens	5-9
1458575-0	1992	Quantitative determination of methemoglobin by measuring the solvent-water proton-nuclear magnetic resonance relaxation rate.	Water	69-74	hemoglobin subunit gamma 2	Homo sapiens	30-43
1458575-1	1992	We report a new method for the quantitative determination of human methemoglobin (metHb) based on the measurement of the solvent-water proton-nuclear magnetic resonance (NMR) relaxation rate R1 [normalized to 1 mmol/L hemoglobin (Hb) concentration].	Water	129-134	hemoglobin subunit gamma 2	Homo sapiens	67-80
8345200-3	1993	Together with vitronectin, clusterin binds to the nascent amphiphilic C5b-9 complex, rendering it water soluble and lytically inactive.	Water	98-103	vitronectin	Homo sapiens	14-25
28823086-6	2017	In presence of Al3+ and/or Hg2+ the receptor (HL) exhibits deep pink colouration and significant enhancement of fluorescence intensity is observed at 564 nm in MeCN:H2O (1:5, v/v) medium.	Water	165-168	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	27-30
1360435-2	1992	Somatostatin induced a significant reduction of renal plasma flow, glomerular filtration rate, and free water clearance in both groups of patients.	Water	104-109	somatostatin	Homo sapiens	0-12
1360435-6	1992	These findings indicate that somatostatin administration induces renal vasoconstriction and impairs glomerular filtration rate, free water clearance, and sodium excretion in cirrhosis by a mechanism unrelated to systemic hemodynamics and endogenous neurohumoral vasoactive systems.	Water	133-138	somatostatin	Homo sapiens	29-41
8368217-0	1993	Tap water should not be used.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
28915436-0	2017	Radiation hazards and lifetime risk assessment of tap water using liquid scintillation counting and high-resolution gamma spectrometry.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
28915436-2	2017	liquid scintillation counting and high-resolution gamma spectrometry are utilized to analyze radionuclides concentrations in tap water of Irbid governorate, Jordan, and study their correlation.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
28915436-6	2017	In addition, the results of both techniques show that storing tap water in drilled wells leads to higher levels of radioactivity concentrations beyond the international permissible limits.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
7685828-2	1993	A 1 ns trajectory from a molecular dynamics study of 1.4 ns total length was used for a detailed analysis of the residence times of water molecules located near 227 selected bovine pancreatic trypsin inhibitor (BPTI) atoms.	Water	132-137	spleen trypsin inhibitor I	Bos taurus	211-215
7685828-6	1993	The residence times of individual water molecules coming near a given BPTI atom, as obtained from the simulation, vary greatly and range between 10 and 500 ps.	Water	34-39	spleen trypsin inhibitor I	Bos taurus	70-74
28915436-7	2017	Furthermore, the average lifetime risk and annual effective dose received by age-grouped inhabitants due to direct and indirect tap water consumption are evaluated, where most of the received dose is attributed to 226Ra.	Water	132-137	nuclear RNA export factor 1	Homo sapiens	128-131
7685828-7	1993	The effective residence time, calculated using a correlation function technique from the presence of all individual water molecules visiting the hydration shell of a given BPTI atom, never exceeds 200 ps.	Water	116-121	spleen trypsin inhibitor I	Bos taurus	172-176
1293141-2	1992	The goal of this study was to measure the prevalence of smoke detectors and safe tap-water temperatures among welfare recipients and compare subjects living in safe and unsafe homes.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
29101851-5	2017	The explicit solvents of dichloromethane (DCM) and water present a disparity of OH bond dissociation enthalpy and free energy (BDE and BDFE).	Water	51-56	homeobox D13	Homo sapiens	127-130
1293141-3	1992	We interviewed 109 black women residing in inner-city Memphis who were receiving Aid to Families with Dependent Children and inspected their homes for functional smoke detectors and safe tap-water temperatures.	Water	191-196	nuclear RNA export factor 1	Homo sapiens	187-190
8399703-2	1993	Many of these hot liquid burns are from contact with hot tap water, usually in the home.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
8399703-7	1993	Mean tap water temperature was 64.2 degrees C at baseline and 61.2 degrees C at follow-up.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	5-8
8399703-10	1993	There were significant decreases in tap water temperature across all groups, but the majority of households still had temperatures above 55 degrees C at the end of the study.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
1488127-0	1992	Regional expression of c-fos antigen in the basal forebrain following intraventricular infusions of angiotensin and its modulation by drinking either water or saline.	Water	150-155	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-28
29101851-8	2017	BDE, IP and PA are each, approximatively constant in mixed solvent treatment in water using n-H2O (n=3,5,8).	Water	80-85	homeobox D13	Homo sapiens	0-3
1488127-9	1992	When water was withheld for 15 min, but then allowed, rats drank the same total volume but c-fos expression was no longer inhibited in either the supraoptic nucleus or paraventricular nucleus.	Water	5-10	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	91-96
8221183-0	1993	[Conservation of tap water in metallo-plastic bags: observed modifications and possible health risks].	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
29903197-4	2017	Then the mice were randomly divided into 4 groups: normal control group, model control group, group of tap water and group of filtered water.	Water	107-112	lymphocyte antigen 6 complex, locus A	Mus musculus	103-106
8396110-3	1993	The subjects ingested 200 ml of tap water hourly.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
1494212-5	1992	Tap water staying overnight in the tube was considered as tube-rinsing solution.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
29903197-8	2017	RESULTS: The p H, TDS, OC, EC, calcium and magnesium in filtered water were higher than that of pure and tap water.	Water	109-114	lymphocyte antigen 6 complex, locus A	Mus musculus	105-108
29903197-21	2017	82) mumol/L) in the mice with filtered water were higher than those of with pure and tap water(( 45.	Water	89-94	lymphocyte antigen 6 complex, locus A	Mus musculus	85-88
29903197-51	2017	CONCLUSION: Compared with pure and tap water, filtered water can reduce the blood pressure of the hypertensive mice by antioxidation and anti-inflammatory.	Water	55-60	lymphocyte antigen 6 complex, locus A	Mus musculus	35-38
1439953-3	1992	The diagnosis was confirmed when samples of tap water that had passed through the in-line deionizer showed low to high calcium concentrations.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
28949147-3	2017	Ultrafast 2D-IR spectroscopy of the SCN- probe in a range of DTAB micelle sizes (w0 = 4 to w0 = 12) shows little if any size dependence on the time scale for spectral diffusion, which is found to be ~3.5 times slower than in bulk water (both D2O and H2O).	Water	230-235	sorcin	Homo sapiens	36-39
1433291-7	1992	The data analysis and the calculations show that B9(Asp) insulin, in water solution at the applied pH (1.8 to 1.9), is a well-defined dimer with no detectable difference between the two monomers.	Water	69-74	NADH:ubiquinone oxidoreductase subunit A3	Homo sapiens	49-64
8390506-14	1993	The present results indicate that the downregulation of glomerular ANF-R1 and the reduced cGMP response may lead to altered sodium and water handling by the kidney of 1-K,1C hypertensive rats.	Water	135-140	natriuretic peptide A	Rattus norvegicus	67-70
8490294-6	1993	ERG changes of Long-Evans rats mediated by this triamterene effect on dopamine concentration were examined after the rats received triamterene with tap water in two experimental series for 5 and 11 days.	Water	152-157	SEC14-like lipid binding 2	Rattus norvegicus	148-151
28949147-3	2017	Ultrafast 2D-IR spectroscopy of the SCN- probe in a range of DTAB micelle sizes (w0 = 4 to w0 = 12) shows little if any size dependence on the time scale for spectral diffusion, which is found to be ~3.5 times slower than in bulk water (both D2O and H2O).	Water	250-253	sorcin	Homo sapiens	36-39
28622555-7	2017	The constructed sensor was applied to determine diuron in enriched samples of orange juice, mineral and tap water which statistical t-test showed accuracy of method.	Water	108-113	nuclear RNA export factor 1	Homo sapiens	104-107
8454613-6	1993	In 2,2,2-trifluoroethanol (TFE)/water mixtures the alpha-helix formation for both hCT and sCT is a two-step process.	Water	32-37	secretin	Homo sapiens	90-93
1438989-8	1992	The calbindin immunoreactivity in the NE cells was stimulated when the calcium concentration of the ambient water was reduced.	Water	108-113	calbindin 1	Gallus gallus	4-13
1329565-10	1992	4) In both water-deprived and water-replete animals, saralasin and/or a V1-antagonist increased the renin response to hypotension, but a combined V1/V2-antagonist did not.	Water	30-35	renin	Canis lupus familiaris	100-105
28645746-3	2017	AQP-4 expression was correlated with percentage water content of brain, Neurological Severity Score (NSS) and rotarod scores.	Water	48-53	aquaporin 4	Mus musculus	0-5
1329029-5	1992	Photosensitization in D2O instead of H2O leads to an increase in the rate of d(TpO) formation that is consistent with a type II (singlet oxygen) reaction mechanism.	Water	37-40	thyroid peroxidase	Homo sapiens	79-82
1279356-2	1992	A component with long T1 and T2 (T1,1 and T2,1) is associated with a large water fraction alpha 1,1 and alpha 2,1 and a component with short T1 and T2 (T1,2 and T2,2) with a small water fraction alpha 1,2 and alpha 2,2.	Water	180-185	solute carrier family 25 member 5	Homo sapiens	42-44
1279356-2	1992	A component with long T1 and T2 (T1,1 and T2,1) is associated with a large water fraction alpha 1,1 and alpha 2,1 and a component with short T1 and T2 (T1,2 and T2,2) with a small water fraction alpha 1,2 and alpha 2,2.	Water	180-185	solute carrier family 25 member 5	Homo sapiens	42-44
1510919-7	1992	This water molecule, not observed in previously determined DHFR structures, is positioned to complete a proposed route for proton transfer from the side-chain carboxylate of E30 to N5 of the pteridine ring.	Water	5-10	dihydrofolate reductase	Gallus gallus	59-63
1510925-1	1992	Nebularine undergoes hydration at the active site of adenosine deaminase, in a reaction analogous to a partial reaction in the displacement of ammonia from adenosine by water, to generate an inhibitory complex that captures much of the binding affinity expected of an ideal transition-state analogue.	Water	169-174	adenosine deaminase	Homo sapiens	53-72
1517486-1	1992	Water deprivation induces the production of the transcription factor Fos in neurons of the neurohypophysial system.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-72
1424511-3	1992	Copepods in the hospital tap water supply were the source for one "outbreak".	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
1588354-3	1992	The questionnaire responses were obtained in 1979 from the four exposed communities and compared to those of a Wyoming community whose tap water levels of arsenic were less than 0.001 mg/l in 1979.	Water	139-144	nuclear RNA export factor 1	Homo sapiens	135-138
1407656-2	1992	When rats were orchidectomized (castrated) and stressed by restraint and immersion in water for 15 min/day for 30 days, significant loss of hippocampal CA3 and CA4 neurons was observed.	Water	86-91	carbonic anhydrase 3	Rattus norvegicus	152-155
1286675-3	1992	EAU was successfully induced with injecting 50 micrograms of IRBP emulsified with Freund"s complete adjuvant into the right hind footpads of Lewis rats.	Water	0-3	retinol binding protein 3	Rattus norvegicus	61-65
1549435-1	1992	Subjects presented with sets of three samples, two of distilled water and one of tap water, were significantly more consistent in choosing the tap water as preferable than they were in identifying it as the odd sample in the set.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	143-146
1549435-1	1992	Subjects presented with sets of three samples, two of distilled water and one of tap water, were significantly more consistent in choosing the tap water as preferable than they were in identifying it as the odd sample in the set.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
1549435-1	1992	Subjects presented with sets of three samples, two of distilled water and one of tap water, were significantly more consistent in choosing the tap water as preferable than they were in identifying it as the odd sample in the set.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	143-146
1549435-1	1992	Subjects presented with sets of three samples, two of distilled water and one of tap water, were significantly more consistent in choosing the tap water as preferable than they were in identifying it as the odd sample in the set.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
1549435-1	1992	Subjects presented with sets of three samples, two of distilled water and one of tap water, were significantly more consistent in choosing the tap water as preferable than they were in identifying it as the odd sample in the set.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	143-146
1737576-7	1992	These findings suggest that PYY acts as an enhancer of sodium chloride and water absorption and as an antagonist to VIP-induced secretion in the colon.	Water	75-80	peptide YY	Rattus norvegicus	28-31
1442005-5	1992	These results indicate that ANP may participate in the regulation of the water electrolyte balance at these sites, which may imply a role for ANP in the regulation of cochlear fluids.	Water	73-78	natriuretic peptide A	Rattus norvegicus	28-31
1449075-2	1992	The responsible ATPase has a typical F1F0 structure, the water-soluble F1 moiety being composed of five different subunits and the more firmly membrane-bound F0 part consisting of three different subunits.	Water	57-62	ATPase	Escherichia coli	16-22
1364146-11	1992	Taken together with previous results showing that the activation of 5HT1C/5HT2 receptors promotes a reduction of the dipsogenic response evoked by water deprivation or by icv injection of angiotensin II or carbachol, the present data suggest that the central serotoninergic system plays a ubiquitous role in the modulation of water intake behavior.	Water	147-152	5-hydroxytryptamine receptor 2C	Rattus norvegicus	68-73
1473090-8	1992	Compared to data derived from the literature, the solute-free water generation during administration of furosemide (CH2O/GFR) was significantly reduced in patients with CF (6.8 +/- 1.5%) as compared with healthy subjects (13.3 +/- 6.1%).	Water	62-67	Rap guanine nucleotide exchange factor 5	Homo sapiens	116-124
1587101-3	1992	The solutions used were aqueous Dioralyte (1.5 S m-1) and tap water (0.04 S m-1).	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
1372320-1	1992	Based on structural information from the Brookhaven Protein Data Bank, the contact surfaces of the proteins lysozyme, trypsin, and BPTI (bovine pancreatic trypsin inhibitor) with a spherical test particle of the size of a water molecule have been calculated and systematically analyzed.	Water	222-227	spleen trypsin inhibitor I	Bos taurus	131-135
1372320-1	1992	Based on structural information from the Brookhaven Protein Data Bank, the contact surfaces of the proteins lysozyme, trypsin, and BPTI (bovine pancreatic trypsin inhibitor) with a spherical test particle of the size of a water molecule have been calculated and systematically analyzed.	Water	222-227	spleen trypsin inhibitor I	Bos taurus	137-172
1343602-4	1992	Water deprivation elevated circulating immunoreactive ANP (Ir-ANP: pg/ml) to 153 +/- 7 (24 h); 174 +/- 1 (48 h) from the control level (109.6 +/- 7.8).	Water	0-5	natriuretic peptide A	Rattus norvegicus	54-57
8382948-2	1993	Hexokinase and glycerokinase were found to be specific for the delta beta, gamma-bidentate Rh(H2O)4ATP isomer as substrate while adenylate kinase was found to specifically catalyze the reaction of the delta beta,gamma-bidentate Rh(H2O)4ATP isomer.	Water	94-97	glycerol kinase	Homo sapiens	15-28
8490948-13	1993	Activation of neurohormonal vasoconstrictor systems and gradually decreased plasma ANF concentrations may contribute to sodium and water retention at different stages of this experimental model of heart failure.	Water	131-136	natriuretic peptide A	Rattus norvegicus	83-86
7679472-4	1993	When medaka were exposed continuously to the alkylating agent methylazoxymethanol (MAM) acetate at levels of 0.1, 0.15 and 0.3 ppm in water, O6-MT activity was markedly reduced from days 1 to 7, with a slight increase thereafter.	Water	134-139	methylated-DNA--protein-cysteine methyltransferase	Oryzias latipes	141-146
8453380-7	1993	Perhaps the most significant difference is the presence in rRTA of an additional active site water.	Water	93-98	RT1 class I, locus A	Rattus norvegicus	59-63
8439534-0	1993	A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water.	Water	129-134	adenosine deaminase	Homo sapiens	62-81
8442518-8	1993	Use of tap water must be carefully monitored, particularly in dressing changes and bathing of surgical patients.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
8253233-3	1993	Trophozoites of PHL/530 adhered in greater numbers to type I lenses (61.4% poly[2-hydroxyethyl methacrylate-38.6% water), with no differences between type II (30% lidofilcon A-70% water), III (55% bufilcon A-45% water) and IV lenses (42% etafilcon A-58% water).	Water	114-119	BCR activator of RhoGEF and GTPase	Homo sapiens	16-19
8253233-3	1993	Trophozoites of PHL/530 adhered in greater numbers to type I lenses (61.4% poly[2-hydroxyethyl methacrylate-38.6% water), with no differences between type II (30% lidofilcon A-70% water), III (55% bufilcon A-45% water) and IV lenses (42% etafilcon A-58% water).	Water	180-185	BCR activator of RhoGEF and GTPase	Homo sapiens	16-19
8253233-3	1993	Trophozoites of PHL/530 adhered in greater numbers to type I lenses (61.4% poly[2-hydroxyethyl methacrylate-38.6% water), with no differences between type II (30% lidofilcon A-70% water), III (55% bufilcon A-45% water) and IV lenses (42% etafilcon A-58% water).	Water	180-185	BCR activator of RhoGEF and GTPase	Homo sapiens	16-19
8212415-0	1993	Relationship between the incidence infection stones and the magnesium-calcium ratio of tap water.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
8212415-1	1993	In a previous study we showed that the magnesium-calcium ratio of tap water is negatively correlated with the incidence of calcium-containing urinary stones.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
8212415-3	1993	The magnesium-calcium ratio of tap water was found to correlate positively with the incidence of struvite stones.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
8212415-4	1993	The tap water magnesium-calcium ratio was high in regions of basalt and sedimentary rock and was low in granite and limestone areas.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
8212415-6	1993	Thus, this study suggested that the incidence of struvite stones is related to the magnesium-calcium ratio of tap water and to the regional geology, as is the case for calcium-containing stones.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	110-113
1469695-3	1992	In 90% H2O solution at pH 3.2, the major species, which is present in &gt; 90%, contains Pro3 and Pro6 in the trans conformation.	Water	7-10	pyrroline-5-carboxylate reductase 1	Homo sapiens	89-93
1482016-4	1992	The fluorine content in the tap water was always under 0.5 mg/l.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
1341197-1	1992	A clinical trial was conducted in three hospitals to determine if common tap water is suitable for use as a conductive medium in electrocardiography (ECG).	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
1304976-3	1992	In order to create experimental conditions employed in a previous study, Sydney tap water (50 mL) was heated at a 10% power level in the 500 W oven.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
1293141-0	1992	Prevalence of smoke detectors and safe tap-water temperatures among welfare recipients in Memphis, Tennessee.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
1283051-2	1992	EAU develops when the IRBP-reactive lymphocytes in the regional lymph-nodes are activated.	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	22-26
1283051-4	1992	In EAU, ten peptide residues p1182-1191 of the IRBP amino acid sequence, were revealed to be sufficiently capable of lymphocyte activation for EAU, and it was also shown that amino acid positions 1182W (tryptophane), 1185G (glycine), 1186V (valine) and 1188P (proline) of IRBP play important roles as the epitopes or agretopes in developing EAU.	Water	3-6	retinol binding protein 3, interstitial	Mus musculus	47-51
1283051-4	1992	In EAU, ten peptide residues p1182-1191 of the IRBP amino acid sequence, were revealed to be sufficiently capable of lymphocyte activation for EAU, and it was also shown that amino acid positions 1182W (tryptophane), 1185G (glycine), 1186V (valine) and 1188P (proline) of IRBP play important roles as the epitopes or agretopes in developing EAU.	Water	143-146	retinol binding protein 3, interstitial	Mus musculus	47-51
1337115-1	1992	The renal kallikrein-kinin system seems to participate in the regulation of blood pressure, control of sodium and water excretion, renal vascular resistance and renin release.	Water	114-119	kallikrein related peptidase 4	Homo sapiens	10-20
1462469-1	1992	After using a whirlpool-spa when the chlorine concentration in the water was very low (0.1 mg/l free chlorine) approximately 20 persons developed a follicular rash.	Water	67-72	surfactant protein A2	Homo sapiens	24-27
1426148-0	1992	Mechanoelectrical transduction, ion movement and water stasis in uromodulin.	Water	49-54	uromodulin	Homo sapiens	65-75
1426148-4	1992	Diffusion experiments with tritiated water also support the hypothesis that uromodulin acts as a water barrier, but allows ion movement.	Water	37-42	uromodulin	Homo sapiens	76-86
1426148-4	1992	Diffusion experiments with tritiated water also support the hypothesis that uromodulin acts as a water barrier, but allows ion movement.	Water	97-102	uromodulin	Homo sapiens	76-86
1415784-8	1992	Cellular localization of these binding sites may relate to their possible involvement in the centrally mediated salt and water regulation and/or CV effects of circulating ANF.	Water	121-126	natriuretic peptide A	Rattus norvegicus	171-174
1447087-0	1992	Continuous measurement of Na concentration in CSF during gastric water infusion in dehydrated rats.	Water	65-70	colony stimulating factor 2	Rattus norvegicus	46-49
1447087-7	1992	These results suggest that water and/or Na movement between blood and CSF is accelerated during restitution from thermal dehydration, acting to prevent overhydration during the early phase of rehydration.	Water	27-32	colony stimulating factor 2	Rattus norvegicus	70-73
1464953-0	1992	[Concentration and form of asbestos fibers in tap drinking water contaminated from a water supply pipe with asbestos-cement].	Water	59-64	nuclear RNA export factor 1	Homo sapiens	46-49
1464953-4	1992	Asbestos fibers were found in the tap water from two areas in which an asbestos-cement pipe was used for public water supply.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
1464953-5	1992	The concentrations of asbestos fibers in the tap water were 2.7 x 10(4) to 27.0 x 10(4) fibers per liter of water in area A and 10.0 x 10(4) to 21.0 x 10(4) in area B.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
1464953-11	1992	Almost all asbestos fibers detected in the tap water possessed the form of thick or sheaved fibers with lengths ranging from ca.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
1464953-17	1992	It was suggested that the contamination of asbestos fibers in the tap water was caused by erosion and peeling off of the inner wall of the asbestos-cement pipe used as a conduit.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
1529338-2	1992	Direct experimental support for this hypothesis has been obtained in studies of the condensation of the 5"-phosphorimidazolide of adenosine (ImpA) with itself and with P1,P2-diadenosine-5",5"-pyrophosphate (AppA) in water in the presence of a montmorillonite clay.	Water	216-221	crystallin gamma F, pseudogene	Homo sapiens	168-173
1400063-1	1992	Increased activity of the renin-angiotensin system may be involved in sodium and water retention during controlled mechanical ventilation (CMV) with positive end-expiratory pressure (PEEP).	Water	81-86	renin	Canis lupus familiaris	26-31
1343602-4	1992	Water deprivation elevated circulating immunoreactive ANP (Ir-ANP: pg/ml) to 153 +/- 7 (24 h); 174 +/- 1 (48 h) from the control level (109.6 +/- 7.8).	Water	0-5	natriuretic peptide A	Rattus norvegicus	62-65
1465560-3	1992	It was shown that while the traditional method for water treatment and disinfection reduces the number of these organisms, it fails to eliminate them completely, particularly in the case of tap water intake from shore intakes of surface waters.	Water	194-199	nuclear RNA export factor 1	Homo sapiens	190-193
28780369-7	2017	Spatial learning deficits in the water maze were mild but persistent and accompanied by reduced numbers of immature neurons in the hippocampus along with reductions in sera levels of the neurotrophin, BDNF.	Water	33-38	brain-derived neurotrophic factor	Rattus norvegicus	201-205
1624594-8	1992	Of six samples of tap water seeded with varying concentrations of Cryptosporidium oocysts, two (10(2) and 10(3) oocysts/l) were positive by both microscopy and EIA, two (10 and 1/l) by EIA alone, and two (0.1/l and unseeded water) were negative by both microscopy and EIA.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
1807842-0	1991	Insensible water loss in resting adults in Kandy, Sri Lanka.	Water	11-16	sorcin	Homo sapiens	50-53
28716609-6	2017	In animals with continuous access to 15% alcohol and water, oxytocin (3.0mg/kg) reduced alcohol consumption only in the first hour of access after treatment, with no significant effects on consumption over the 24-hr period.	Water	53-58	oxytocin	Mus musculus	60-68
1807842-6	1991	However, when renal excretion of water is impaired, it is safer to err on the side of mild dehydration than to attempt complete hydration.	Water	33-38	solute carrier family 7 member 1	Homo sapiens	67-70
1535535-1	1992	We tested a report that atrial natriuretic peptide (ANP) injected into, or near, the subfornical organ (SFO) will reduce the water consumption of previously water deprived rats and that suggested ANP acts on neurons in the SFO to bring about this action.	Water	125-130	natriuretic peptide A	Rattus norvegicus	24-50
1535535-1	1992	We tested a report that atrial natriuretic peptide (ANP) injected into, or near, the subfornical organ (SFO) will reduce the water consumption of previously water deprived rats and that suggested ANP acts on neurons in the SFO to bring about this action.	Water	125-130	natriuretic peptide A	Rattus norvegicus	52-55
1535535-1	1992	We tested a report that atrial natriuretic peptide (ANP) injected into, or near, the subfornical organ (SFO) will reduce the water consumption of previously water deprived rats and that suggested ANP acts on neurons in the SFO to bring about this action.	Water	157-162	natriuretic peptide A	Rattus norvegicus	24-50
29114420-0	2017	Hypocapnia Caused by a Cracked Water Trap.	Water	31-36	TRAP	Homo sapiens	37-41
1535535-1	1992	We tested a report that atrial natriuretic peptide (ANP) injected into, or near, the subfornical organ (SFO) will reduce the water consumption of previously water deprived rats and that suggested ANP acts on neurons in the SFO to bring about this action.	Water	157-162	natriuretic peptide A	Rattus norvegicus	52-55
1535825-0	1992	Central administration of atrial natriuretic peptide suppresses sodium and water intake of sheep.	Water	75-80	natriuretic peptides A	Ovis aries	26-52
1535825-4	1992	infusion of ANP decreased (p less than 0.01) Na and water intakes of water-deprived sheep but did not affect significantly Na or water intakes of Na and water-replete sheep.	Water	52-57	natriuretic peptides A	Ovis aries	12-15
1535825-4	1992	infusion of ANP decreased (p less than 0.01) Na and water intakes of water-deprived sheep but did not affect significantly Na or water intakes of Na and water-replete sheep.	Water	69-74	natriuretic peptides A	Ovis aries	12-15
1535825-4	1992	infusion of ANP decreased (p less than 0.01) Na and water intakes of water-deprived sheep but did not affect significantly Na or water intakes of Na and water-replete sheep.	Water	69-74	natriuretic peptides A	Ovis aries	12-15
1535825-4	1992	infusion of ANP decreased (p less than 0.01) Na and water intakes of water-deprived sheep but did not affect significantly Na or water intakes of Na and water-replete sheep.	Water	69-74	natriuretic peptides A	Ovis aries	12-15
1939644-8	1991	Injection with 1-50 ng of in vitro-transcribed GLUT1 mRNA increased 3H-methylglucose uptake greater than 15-fold in a cytochalasin B-sensitive manner and increased Pf from (3.7 +/- 0.4) x 10(-4) cm/s (SE, n = 16, 10 degrees C) in water-injected oocytes up to (13 +/- 1) x 10(-4) cm/s (n = 18).	Water	230-235	solute carrier family 2 member 1	Homo sapiens	47-52
1741766-1	1991	2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) is a more water-soluble analogue of the quinazoline-based thymidylate synthase (TS) inhibitor, N10-propargyl-5,8-dideazafolic acid (CB3717).	Water	79-84	thymidylate synthase	Mus musculus	127-147
1535825-6	1992	infusion of ANP decreased (P less than 0.05) Na and water intakes of sheep infused i.c.v.	Water	52-57	natriuretic peptides A	Ovis aries	12-15
29169414-7	2017	Results BI-1 over-expression improved neurobehavioral score, decreased brain water content and hippocampal neuron apoptosis rate, and also down-regulated GRP78 and IRE1 protein levels in the rats with SAH.	Water	77-82	transmembrane BAX inhibitor motif containing 6	Rattus norvegicus	8-12
1525780-7	1992	Water molecules and hydroxyl groups are chelated between O-6 and O-5 of at least five glucose residues.	Water	0-5	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	57-68
1958444-8	1991	with isovolumetric amounts of normal saline while insensible losses were compensated for by taking tap water orally.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
28963642-8	2017	The percent recovery of naphthalene obtained from tap water was ranged between 93.8 and 102.2.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
1663818-3	1991	Dehydration, either by water deprivation of normal rats, or chronic dehydration present in homozygous Brattleboro rats lacking vasopressin, results in large increases in ANP binding in receptor number in the subfornical organ.	Water	23-28	natriuretic peptide A	Rattus norvegicus	170-173
1835448-10	1991	In conclusion massive doses of atrial natriuretic peptide are required to produce any change in intestinal salt and water transport in normal, non-volume expanded rats; these effects could be a non-specific or "toxic" response.	Water	116-121	natriuretic peptide A	Rattus norvegicus	31-57
1535725-1	1992	Atrial natriuretic peptide (ANP) present in the brain has been reported to have profound effects on water and salt metabolism.	Water	100-105	natriuretic peptide A	Rattus norvegicus	0-26
1535725-1	1992	Atrial natriuretic peptide (ANP) present in the brain has been reported to have profound effects on water and salt metabolism.	Water	100-105	natriuretic peptide A	Rattus norvegicus	28-31
1535725-2	1992	This study was designed to observe the effect of intracerebroventricular (ICV) injection of ANP on drinking behavior of rats, induced by centrally administered angiotensin II (Ang II) and 24-hours water deprivation, by using a T-maze to measure the speed they ran in a runway for water rewards.	Water	197-202	natriuretic peptide A	Rattus norvegicus	92-95
1535725-3	1992	In 24-hours water deprived rats ICV injection of ANP resulted in a significant decrease of either running speed or water intake.	Water	12-17	natriuretic peptide A	Rattus norvegicus	49-52
1535725-3	1992	In 24-hours water deprived rats ICV injection of ANP resulted in a significant decrease of either running speed or water intake.	Water	115-120	natriuretic peptide A	Rattus norvegicus	49-52
28905057-0	2017	A water-mediated and substrate-assisted aminoacylation mechanism in the discriminating aminoacyl-tRNA synthetase GlnRS and non-discriminating GluRS.	Water	2-7	glutaminyl-tRNA synthetase 1	Homo sapiens	113-118
1555850-1	1992	We have used the finite-difference time domain (FDTD) method to calculate the SAR distributions from an annular-phased array of eight dipole antennas coupled through water "boluses" in anatomically based three-dimensional models of the human body.	Water	166-171	sarcosine dehydrogenase	Homo sapiens	78-81
28905057-5	2017	Our investigations demonstrated the feasibility of a water-mediated, substrate-assisted catalysis pathway with rate limiting steps occurring at energy barriers of 25.0 and 25.4 kcal mol-1 for GlnRS and ND-GluRS, respectively.	Water	53-58	glutaminyl-tRNA synthetase 1	Homo sapiens	192-197
1770502-1	1991	The activity patterns during development for acid phosphatase (Ac-P), alkaline phosphatase (A1-P), beta-glucuronidase (beta G), and UDP-glucuronyltransferase (UDPGT) have been determined in various tissues of the rat for corn oil and distilled water controls as well as in animals prenatally exposed to four fetotoxic chemicals.	Water	244-249	glucuronidase, beta	Rattus norvegicus	99-117
28979186-3	2017	Astrocytes are widely considered to be particularly susceptible to cellular edema due to selective expression of the water channel aquaporin-4 (AQP4).	Water	117-122	aquaporin 4	Homo sapiens	144-148
1425044-4	1992	EAU was successfully induced by injection of emulsified IRBP 50 micrograms with Freund"s complete adjuvant into the footpad of Lewis rats.	Water	0-3	retinol binding protein 3	Bos taurus	56-60
28955704-1	2017	QUESTION: Can a multifaceted statewide communications campaign motivate behavior change in low-income Colorado families to limit children"s fruit juice consumption and increase children"s consumption of tap water to prevent tooth decay?	Water	207-212	nuclear RNA export factor 1	Homo sapiens	203-206
1531208-3	1992	In the rat, intraperitoneal injections of pepsanurin (0.5 ml/100 g body wt) significantly inhibited the effects of an intravenous bolus of atrial natriuretic peptide (ANP) (0.5 micrograms) on water, sodium, and potassium excretion without altering systemic blood pressure.	Water	192-197	natriuretic peptide A	Rattus norvegicus	139-165
1665571-2	1991	In vivo, intravenous administration of rat ANP(99-126) induced diuresis and natriuresis in conjunction with a significant decrease in intestinal water (basal, 37.1 +/- 5.7 versus ANP 28.5 +/- 6.0 microliters/cm per 20 min, P less than 0.05) and Na+ (4.0 +/- 0.7 versus 2.8 +/- 0.9 mumol/cm per 20 min, P less than 0.05) absorption (n = 9).	Water	145-150	natriuretic peptide A	Rattus norvegicus	43-46
28955704-4	2017	The purpose of this campaign, "Cavities Get Around," was to motivate families to limit children"s fruit juice consumption and increase consumption of tap water to protect baby teeth from caries, while also building public will for children"s oral health.	Water	154-159	nuclear RNA export factor 1	Homo sapiens	150-153
1796181-5	1991	CCK appears to be directly responsible for the protein and also water response to duodenal infusion of oleic acid, and to be indirectly involved in bicarbonate stimulation.	Water	64-69	cholecystokinin	Rattus norvegicus	0-3
1621355-6	1992	Each container was thoroughly cleaned, and the contents vacuum filtered and washed with 1 L of tap water.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
28870197-14	2017	The antiproliferative activity against Hep-G2 hepatoma cancer cell line was demonstrated by n-hexane, ethylacetate and methanol-distilled water (IC50 8.65-8.95 mug/ml) extracts.	Water	138-143	DNL-type zinc finger	Homo sapiens	39-42
28877240-10	2017	Consistent with this finding, one of the water channels, Aquaporin-5 (AQP5) was mislocalized in the cytoplasm of the Runx1 mutants, suggesting a novel role of Runx1 in the membrane trafficking of AQP5.	Water	41-46	aquaporin 5	Mus musculus	57-68
1733292-8	1992	High-performance liquid chromatographic separation and RIA analysis of veratridine- and water deprivation-stimulated angiotensin release demonstrated that 93.4% of the releasable angiotensin coeluted with ANG III, whereas only 6.8% eluted with authentic ANG II.	Water	88-93	angiogenin	Rattus norvegicus	205-208
1733292-8	1992	High-performance liquid chromatographic separation and RIA analysis of veratridine- and water deprivation-stimulated angiotensin release demonstrated that 93.4% of the releasable angiotensin coeluted with ANG III, whereas only 6.8% eluted with authentic ANG II.	Water	88-93	angiogenin	Rattus norvegicus	254-257
1681489-3	1991	Somatostatin decreases the renal plasma flow, glomerular filtration rate, osmotic and free water clearances, sodium and potassium excretion and the tubular reabsorption of phosphorus while urinary osmolality increases.	Water	91-96	somatostatin	Homo sapiens	0-12
1681489-5	1991	The antidiuretic activity of somatostatin is due to a) a direct haemodinamic effect, b) an influence on the renal tubular transport as well and also c) because of change the water handling in the collecting ducts.	Water	174-179	somatostatin	Homo sapiens	29-41
28877240-10	2017	Consistent with this finding, one of the water channels, Aquaporin-5 (AQP5) was mislocalized in the cytoplasm of the Runx1 mutants, suggesting a novel role of Runx1 in the membrane trafficking of AQP5.	Water	41-46	aquaporin 5	Mus musculus	70-74
28877240-10	2017	Consistent with this finding, one of the water channels, Aquaporin-5 (AQP5) was mislocalized in the cytoplasm of the Runx1 mutants, suggesting a novel role of Runx1 in the membrane trafficking of AQP5.	Water	41-46	runt related transcription factor 1	Mus musculus	117-122
1419080-2	1992	Water-CVE completely inhibited potato 5-lipoxygenase activity at 250 micrograms/ml, partially inhibited soybean 15-lipoxygenase at pH 7.4 and had no effect either on this 15-lipoxygenase at its optimal activity pH (pH 9) or on Lupinus albus 5-, 8-, 15-lipoxygenase.	Water	0-5	5-lipoxygenase	Solanum tuberosum	38-52
28877240-10	2017	Consistent with this finding, one of the water channels, Aquaporin-5 (AQP5) was mislocalized in the cytoplasm of the Runx1 mutants, suggesting a novel role of Runx1 in the membrane trafficking of AQP5.	Water	41-46	runt related transcription factor 1	Mus musculus	159-164
1787649-2	1991	Multiple regression analysis of the results of 3,240 simulated applications of the model (1,620 HDF, 1,080 AFB, 540 HD) showed that, during HDF and AFB, there is a close correlation (R2 = 0.92 and 0.91) between plasma water sodium concentration [( Na+P]) and a set of three variables: 1) the sodium gradient between plasma water and dialysate, 2) the sodium concentration of the substitution fluid and 3) ultrafiltration (UF) rate.	Water	218-223	catenin beta like 1	Homo sapiens	248-253
28877240-10	2017	Consistent with this finding, one of the water channels, Aquaporin-5 (AQP5) was mislocalized in the cytoplasm of the Runx1 mutants, suggesting a novel role of Runx1 in the membrane trafficking of AQP5.	Water	41-46	aquaporin 5	Mus musculus	196-200
1531647-3	1992	Initial drinking of tap water (15 degrees C) was 216 +/- 30 ml/7 min (P less than 0.05) with Hypo-air, decreased to 108 +/- 28 ml/7 min (P less than 0.05) with Hypo-H2O, and was 10-50 ml/10-30 min thereafter.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
1859066-7	1991	The efficacy of CFI resulted both from the injection of oxygen into the trachea and from the maintenance of positive alveolar pressure induced by air entrainment (mean 10.4 +/- 1.1 cm H2O), preventing a fall in lung volume usually occurring after disconnection (+338 +/- 88 ml during CFI versus -344 +/- 64 ml during apnea, p less than 0.01).	Water	184-187	complement factor I	Homo sapiens	16-19
1892621-4	1991	Tap water was used commonly for rinsing suction tips while suctioning patients even with tympanic membrane perforations (45%).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
1910750-1	1991	Experiments were performed to measure the transfer of trichloroethylene (TCE), a volatile organic compound (VOC), from tap water in showers to indoor air.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
1910750-2	1991	In these experiments, the loss of TCE from tap water in the shower is based on the difference between influent and effluent concentrations.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
1934765-5	1991	He vomited just after he drank excessive water with his mouth directly to the tap for several minutes, and soon fell into loss of consciousness.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	78-81
2000858-5	1991	When variables were examined by univariate analysis, controls deleted reports of tap water consumption (any vs. more) more often than did cases.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
1817621-2	1991	We found that the incidence and severity of oxygen desaturation were reduced significantly in the 5-cm H2O CPAP group.	Water	103-106	centromere protein J	Homo sapiens	107-111
2026713-0	1991	Gas chromatographic-mass spectrometric characterization of volatile organic compounds in Barcelona tap water.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
2026713-2	1991	Volatile organic compounds (VOCs) from Barcelona tap water were isolated by closed-loop stripping analysis (CLSA) and identified and determined by gas chromatography-mass spectrometry.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
2026713-3	1991	The results showed that the Ter river gives the better quality tap water.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
1679107-4	1991	In the HA rats, the increase in water and salt excretion were comparatively mild, and the only statistically significant response was to the higher dose of ANF.	Water	32-37	natriuretic peptide A	Rattus norvegicus	156-159
2000176-3	1991	An increase of gastric emptying was noted after alkaline bicarbonated water versus tap water with significant differences at 30" (p less than 0.05), 60" (p less than 0.01) and 120" (p less than 0.05).	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
2000176-5	1991	Alkaline bicarbonated water induced less intensive gallbladder emptying with statistical difference versus tap water at 60" and 120" from the standard meal (p less than 0.01).	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
1834955-6	1991	Based on these results, the preferential increase in the free form of ANP in nephrotic rats is considered to be a compensatory phenomenon induced by the decreased renal ability to eliminate sodium and water.	Water	201-206	natriuretic peptide A	Rattus norvegicus	70-73
1662352-6	1991	Tap water and bottled water are under strict vigilance.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
1844270-1	1991	A quasi-historical cohort study method was used to collect the data of male stomach and liver cancer death from 1984 to 1988 in male residents (&gt; or = 30 years old) of three tap-water-drinking communities at the upper, middle and lower reaches of the Huangpu River.	Water	181-186	nuclear RNA export factor 1	Homo sapiens	177-180
1844271-1	1991	A quasi-historical cohort study method was used to collect the data of male stomach and liver cancer death and the data of exposure to relevant risk factors from 1984 to 1988 in male tap-water- and raw-water-drinking cohorts (&gt; or = 30 years old) at both the upper and lower reaches of the Huangpu River.	Water	187-192	nuclear RNA export factor 1	Homo sapiens	183-186
1822018-4	1991	The modifications for the spin-echo case are given and applied to recent measurements on the anisotropy of the self-diffusion of water in striated muscle and to measurements on cysts of the brine shrimp.	Water	129-134	spindlin 1	Homo sapiens	26-30
1824802-6	1991	Atrial natriuretic peptide appears to have a pharmacological effect on ischemic brain edema, possibly by suppressing the elevation of water content through regulation of electrolyte transport in the brain.	Water	134-139	natriuretic peptide A	Rattus norvegicus	0-26
1980681-4	1990	This implicates, for the first time, domestic tap water as the source of Acanthamoeba sp.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
2230333-6	1990	The increased counts in tap water, compared with canal water, were recorded in winter for bacteria and in spring for fungi.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
2287784-0	1990	Routes of chloroform exposure and body burden from showering with chlorinated tap water.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
2287785-0	1990	Chloroform exposure and the health risk associated with multiple uses of chlorinated tap water.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
1982201-1	1990	AHR-13268D (4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1- piperidinyl]propoxy]benzoic acid, sodium salt) is a potent, long-acting water soluble, antiallergic and antihistaminic agent.	Water	130-135	aryl hydrocarbon receptor	Cavia porcellus	0-3
2087479-3	1990	Tap water was available ad lib.	Water	4-9	SEC14-like lipid binding 2	Rattus norvegicus	0-3
1698788-9	1990	The data are compatible with pb2 forming a large water-filled transmembrane channel.	Water	49-54	pore-forming tail tip protein	Escherichia phage T5	29-32
1965278-2	1990	The formation of hydroxyl radical was detected by water-soluble spin-traps, alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN) and 5,5-dimethyl-1-pyrroline N-oxide (DMPO).	Water	50-55	spindlin 1	Homo sapiens	64-68
2074020-1	1990	According to the results of the studies the reason of the worsening of water quality in the ozonizer [correction of ozonating] installations of household water supply of ships is the presence of negative biological processes in the system of household and drinking water in combination with the peculiarities of its operation and reliability of functioning of the ship ozonizer [correction of ozonating] station.	Water	71-76	inositol polyphosphate-5-phosphatase D	Homo sapiens	170-174
2074020-2	1990	New technological designs and automated control methods, maintaining the residual ozone doses in the ship network, are needed to keep the drinking quality of water in the system.	Water	158-163	inositol polyphosphate-5-phosphatase D	Homo sapiens	101-105
2263557-5	1990	Feed intake was significantly reduced in association with either level of sucrose in the water.	Water	89-94	FI	Gallus gallus	0-11
2263557-6	1990	In Experiment 1, egg weights from hens receiving sucrose water were significantly below those of controls, probably because of lowered feed intake.	Water	57-62	FI	Gallus gallus	135-146
2290834-6	1990	This seems to be the result of the stability of the five-membered ring that is formed by the carboxylate anion hydrogen bonded to a ligand water molecule and the metal ion in the syn position.	Water	139-144	synemin	Homo sapiens	179-182
2203255-4	1990	The meal with 90 mL tap water was ingested over 10 and 30 min.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
2167151-1	1990	In [3H]inositol-labeled membranes prepared from Swiss mouse 3T3 and human small cell lung carcinoma cells, [Tyr4]-bombesin stimulated production of water-soluble inositol phosphates.	Water	148-153	gastrin releasing peptide	Homo sapiens	114-122
2167202-7	1990	Increasing the osmolality of the incubation to 600 mosmol/kg water also abolished the effect of AVP on PI hydrolysis in the inner medulla.	Water	61-66	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	96-99
2390700-3	1990	If they find tap water unpalatable and drink bottled water instead, they could significantly increase their daily calcium intake by as much as 1.5 g. The majority of bottled waters presently available in this country, together with tap water samples from throughout the British Isles, have been analysed and the results suggest that there are some waters which stone formers should avoid.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
19912752-11	1990	For comparison, intense fos-like IR in the hippocampal formation and in the paraventricular nucleus of the hypothalamus was observed following metrazol-induced seizure activity and water deprivation, respectively.	Water	181-186	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	24-27
1366151-2	1992	One hundred patients suffering from low-back pain were given a 14-day treatment in the termomineral water (T--36 degrees C) of the Moravci Spa.	Water	100-105	surfactant protein A2	Homo sapiens	139-142
1839968-0	1991	CNP-22 stimulates, rather than inhibits, water drinking in the rat: evidence for a unique biological action of the C-type natriuretic peptides.	Water	41-46	natriuretic peptide C	Rattus norvegicus	0-3
1839968-3	1991	The action of CNP to stimulate water drinking is not due to competition with ANP for the clearance receptor which recognizes both peptides since the ligand specific for that binding site, C-ANF 4-23, like ANP, inhibits water drinking under the same conditions.	Water	31-36	natriuretic peptide C	Rattus norvegicus	14-17
1839968-3	1991	The action of CNP to stimulate water drinking is not due to competition with ANP for the clearance receptor which recognizes both peptides since the ligand specific for that binding site, C-ANF 4-23, like ANP, inhibits water drinking under the same conditions.	Water	219-224	natriuretic peptide C	Rattus norvegicus	14-17
1820466-0	1991	If the tap water smells foul, think MTBE.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
11537636-2	1991	Removal of water by evaporation or by freezing often results in formation of an amorphous state (Parks et al., 1928; Troy and Sharp, 1930; Kauzmann, 1948; Bushill et al., 1965; White and Cakebread, 1966; Slade and Levine, 1991).	Water	11-16	TNF receptor superfamily member 19	Homo sapiens	117-121
1935501-2	1991	In the present study, which was also performed in rats, we show that CCK also promotes the translocation of albumin, electrolytes, and water into the lumen of the intestine.	Water	135-140	cholecystokinin	Rattus norvegicus	69-72
1911755-9	1991	Quantitative analysis of the FT-IR spectra of calmodulin (67% alpha-helix) and parvalbumin (68% alpha-helix) in H2O in the presence of Ca2+ gives helical contents similar to those reported by X-ray studies.	Water	112-115	parvalbumin	Homo sapiens	79-90
1833989-9	1991	The renal nerves and ANF appear to play a larger role in the acute control of sodium and water excretion in MW rats compared to rats of the Okamoto-Aoki strain.	Water	89-94	natriuretic peptide A	Rattus norvegicus	21-24
1746727-2	1991	Undamaged lungs are removed from the body and then tracheally cannulated and lavaged with tap water more than 250 times.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
1832424-2	1991	Accordingly, seven normal weight, ovulatory women were randomized to receive first either a 75 g glucose dose or a sham control for diurnal rhythm consisting of distilled water at 1700 h. After this insulin stimulus, DHEA-S suppressed below sham control at 90 and 120 min (P less than 0.05) whereas delta 4A suppress at 60, 90, and 120 min (P less than 0.05).	Water	171-176	sulfotransferase family 2A member 1	Homo sapiens	217-223
1759089-4	1991	Effective CPAP (9 +/- 3 cm H2O) was documented in 320 patients on single night studies and resulted in a 99% reduction in the frequency of obstructive events and improvement in the lowest O2 saturation to 94 +/- 5%.	Water	27-30	centromere protein J	Homo sapiens	10-14
1949011-2	1991	It is a water-soluble cholinesterase inhibitor whose estimated rat LD50 is 9.2 mg/kg, ip.	Water	8-13	butyrylcholinesterase	Rattus norvegicus	22-36
1790169-1	1991	The conjugates of glucose-6-phosphate dehydrogenase, lactate dehydrogenase, and malate dehydrogenase with progesterone and cortisol, containing 1-40 steroid molecules per enzyme molecule, were obtained by the reactions of N-succinimide esters of the 3-[O-(carboxymethyl)oximes)] of cortisol and progesterone with a protein in a water-DMFA (10%) medium.	Water	328-333	glucose-6-phosphate dehydrogenase	Homo sapiens	18-51
1790169-1	1991	The conjugates of glucose-6-phosphate dehydrogenase, lactate dehydrogenase, and malate dehydrogenase with progesterone and cortisol, containing 1-40 steroid molecules per enzyme molecule, were obtained by the reactions of N-succinimide esters of the 3-[O-(carboxymethyl)oximes)] of cortisol and progesterone with a protein in a water-DMFA (10%) medium.	Water	328-333	malic enzyme 1	Homo sapiens	80-100
8577140-3	1991	Vitamin B1 deficiency (hydroxy thiamine in drinking water at a dose of 2 mg/kg body weight for 15 days) led to a substantial decrease of TK in blood, AlAT and AsAT in the spleen; it diminished AsAT and increased AlAT in the thymus.	Water	52-57	transketolase	Rattus norvegicus	137-139
8577140-3	1991	Vitamin B1 deficiency (hydroxy thiamine in drinking water at a dose of 2 mg/kg body weight for 15 days) led to a substantial decrease of TK in blood, AlAT and AsAT in the spleen; it diminished AsAT and increased AlAT in the thymus.	Water	52-57	glutamic--pyruvic transaminase	Rattus norvegicus	150-154
8577140-3	1991	Vitamin B1 deficiency (hydroxy thiamine in drinking water at a dose of 2 mg/kg body weight for 15 days) led to a substantial decrease of TK in blood, AlAT and AsAT in the spleen; it diminished AsAT and increased AlAT in the thymus.	Water	52-57	glutamic--pyruvic transaminase	Rattus norvegicus	212-216
1888328-10	1991	When incorporation of [18O] from water catalyzed by cytosolic epoxide hydrolase was measured, the (2S,3S)-enantiomer gave 12% incorporation into the benzylic carbon and the (2R,3R)-enantiometer gave 40% incorporation into the benzylic carbon.	Water	33-38	epoxide hydrolase 2, cytoplasmic	Mus musculus	52-79
1859062-4	1991	Endothelin-1 also elicited immediate bronchoconstriction; lung resistance increased from 0.148 +/- 0.030 to 0.992 +/- 0.274 cm H2O/L/s (p less than 0.005) after 10(-8) mol/kg endothelin-1 given intravenously.	Water	127-130	endothelin-1	Cavia porcellus	0-12
1859649-4	1991	Different fixation methods used on the CNS, rinsed or not rinsed in tap water, led us to suggest that the relatively high calcium content in the tap water in our part of the country was the cause.	Water	149-154	nuclear RNA export factor 1	Homo sapiens	145-148
1935176-4	1991	The competitive effect of Ca2+/trehalose is interpreted as a consequence of the different amount of interfacial water displaced by each compound in their adsorption on the water/lipid interface.	Water	112-117	carbonic anhydrase 2	Homo sapiens	26-29
1935176-4	1991	The competitive effect of Ca2+/trehalose is interpreted as a consequence of the different amount of interfacial water displaced by each compound in their adsorption on the water/lipid interface.	Water	172-177	carbonic anhydrase 2	Homo sapiens	26-29
2041094-2	1991	Using purified gp160s, a water-soluble form of env purified from a recombinant vaccinia virus expression system, we have measured the masses of several hundred individual molecules by dark-field scanning transmission electron microscopy.	Water	25-30	endogenous retrovirus group K member 20	Homo sapiens	47-50
1832749-6	1991	The h-ANP antiserum had no effect on the urine volume in 48-h water-deprived rats, suggesting a primary effect of endogenous ANP in the brain on the spontaneous water intake in rats given water ad libitum.	Water	161-166	natriuretic peptide A	Rattus norvegicus	125-128
1832749-6	1991	The h-ANP antiserum had no effect on the urine volume in 48-h water-deprived rats, suggesting a primary effect of endogenous ANP in the brain on the spontaneous water intake in rats given water ad libitum.	Water	161-166	natriuretic peptide A	Rattus norvegicus	125-128
1832749-7	1991	These results suggest that ANP may have a physiologically important role in the central regulation of the water and electrolyte metabolism.	Water	106-111	natriuretic peptide A	Rattus norvegicus	27-30
1920900-2	1991	When acini were incubated with [3H] choline in the presence of 1 nM CCK-octapeptide (CCK8) for 60 min, the incorporations of [3H] choline to both water soluble choline metabolites and PC in acini were reduced by CCK8 to 74% and 41% of control, respectively.	Water	146-151	cholecystokinin	Rattus norvegicus	68-71
2021632-8	1991	The sedimentation coefficient (5.85) determined by analytical ultracentrifugation and the Stokes radius (47 A) determined by polyacrylamide gradient gel electrophoresis indicate that the 150,000 molecular weight MTP complex is asymmetric and/or has an unusually high water of hydration.	Water	267-272	microsomal triglyceride transfer protein	Homo sapiens	212-215
2069737-1	1991	Cholecystokinin (CCK) is a brain-gut neuropeptide and hormone previously shown to inhibit alcohol intake in water- or food-deprived rats.	Water	108-113	cholecystokinin	Rattus norvegicus	0-15
2069737-1	1991	Cholecystokinin (CCK) is a brain-gut neuropeptide and hormone previously shown to inhibit alcohol intake in water- or food-deprived rats.	Water	108-113	cholecystokinin	Rattus norvegicus	17-20
2069737-6	1991	During LAP, CCK reduced alcohol intake and increased water intake more potently in the dark phase.	Water	53-58	cholecystokinin	Rattus norvegicus	12-15
2069737-8	1991	CCK more effectively reduced alcohol intake in LAP, than in a 23.3-h water-deprivation procedure for inducing alcohol intake in a 2-bottle choice test with water.	Water	156-161	cholecystokinin	Rattus norvegicus	0-3
2069737-10	1991	The alcohol satiation effect of CCK is independent of prior deprivation and not an artifact of thirst reduction, debilitation, or conditioned aversion, because CCK strongly increased water intake in the limited access procedure, and ethanol preference remained robust after experience with CCK.	Water	183-188	cholecystokinin	Rattus norvegicus	32-35
2069737-10	1991	The alcohol satiation effect of CCK is independent of prior deprivation and not an artifact of thirst reduction, debilitation, or conditioned aversion, because CCK strongly increased water intake in the limited access procedure, and ethanol preference remained robust after experience with CCK.	Water	183-188	cholecystokinin	Rattus norvegicus	160-163
2069737-10	1991	The alcohol satiation effect of CCK is independent of prior deprivation and not an artifact of thirst reduction, debilitation, or conditioned aversion, because CCK strongly increased water intake in the limited access procedure, and ethanol preference remained robust after experience with CCK.	Water	183-188	cholecystokinin	Rattus norvegicus	160-163
1882231-6	1991	In the case of tap water, the observed ranges for salinity, chloride and sodium were 0.7-1.5 ppt, and 280-750 and 140-400 mg l-1, respectively.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
1882231-7	1991	The quality of tap water was assessed by comparing values with WHO guidelines.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
1908804-0	1991	[Mutagenicity background monitoring of the River Don delta water].	Water	59-64	seven up	Drosophila melanogaster	49-52
1908804-1	1991	The mutagenicity of 14 samples of Don river delta water was studied by the Ames test and the technique of estimation of Drosophila dominant lethals.	Water	50-55	seven up	Drosophila melanogaster	34-37
1908804-2	1991	Experiments revealed that mutagenic pollution of Don river delta water was total at least in April--May 1989.	Water	65-70	seven up	Drosophila melanogaster	49-52
24242170-2	1991	The predominance of water loss from H(+)(H20)(A) l=3, where A = acetone, suggests that the solvation sphere around H3O(+) does not close at l = 3, contrary to the case of acetonitrile or dimethyl ether.	Water	20-25	H3 clustered histone 15	Homo sapiens	115-121
2114483-2	1990	There are three main sources of drinking water: tap, private treated, and bottled waters.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	48-51
2114483-3	1990	The findings revealed that tap water had highest level of all chemicals studies (except silica) compared to other waters.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
2114483-4	1990	Sodium level in tap water ranged from 100 to 545.9 mg/l, with an average of 309.4 mg/l.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
1900836-3	1991	We have now found that synapsin I forms a stable monolayer at an air-water interface which can be compressed under a lateral force of up to 60 dynes/cm, indicating the presence of amphiphilic characteristics in its structure.	Water	69-74	synapsin I	Homo sapiens	23-33
28780636-1	2017	The photoconversion of 2-chloronaphthalene (CN-2) in water in a simulated sunlight system was investigated.	Water	53-58	carnosine dipeptidase 2	Homo sapiens	44-48
24414690-3	1991	Appreciable extents of cytochrome b-559HP photoreduction were observed at DCMU concentrations which completely abolished the electron transport from water to methyl viologen under the same experimental conditions.	Water	149-154	mitochondrially encoded cytochrome b	Homo sapiens	23-35
2159006-2	1990	Oligomycin sensitivity-conferring protein (OSCP) is a water-soluble subunit of bovine heart mitochondrial H(+)-ATPase (F1-F0).	Water	54-59	ATP synthase peripheral stalk subunit OSCP	Bos taurus	0-41
2159006-2	1990	Oligomycin sensitivity-conferring protein (OSCP) is a water-soluble subunit of bovine heart mitochondrial H(+)-ATPase (F1-F0).	Water	54-59	ATP synthase peripheral stalk subunit OSCP	Bos taurus	43-47
28780636-3	2017	The results showed that CN-2 could be transformed in water under the irradiation.	Water	53-58	carnosine dipeptidase 2	Homo sapiens	24-28
28417589-0	2017	Glutathione-stabilized Cu nanocluster-based fluorescent probe for sensitive and selective detection of Hg2+ in water.	Water	111-116	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	103-106
2118739-0	1990	Use of masking agents in the determination of lead in tap water by flame atomic absorption spectrometry with flow injection pre-concentration.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
2118739-5	1990	Recoveries from tap water samples, to which various amounts of lead had been added, ranged from 94 to 108%.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
2118739-6	1990	Results of analyses of tap water samples using this method were in good agreement with those obtained by electrothermal atomic absorption spectrometry.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
17014766-0	1991	Simulation of an oscillatory reaction of alcohol dehydrogenase in an oil/water system.	Water	73-78	aldo-keto reductase family 1 member A1	Homo sapiens	41-62
29084674-6	2017	Water extracts of SNF have obvious protective effects on hepatic injury induced by CCl4 in mice.	Water	0-5	chemokine (C-C motif) ligand 4	Mus musculus	83-87
1989675-2	1991	Diethyl p-nitrophenyl phosphate treated gastric lipases were also inactive on water-soluble p-nitrophenyl acetate, whereas the modified pancreatic lipase was still able to hydrolyze this water-soluble substrate.	Water	187-192	pancreatic lipase	Homo sapiens	136-153
1997324-3	1991	GALA is a water-soluble peptide with an aperiodic conformation at neutral pH, and becomes an amphipathic alpha helix as the pH is lowered to 5, where it interacts with phospholipid bilayers.	Water	10-15	galactosidase alpha	Homo sapiens	0-4
1836927-8	1991	The latter is in keeping with the known function of ANF in regulating water and electrolyte fluxes.	Water	70-75	natriuretic peptide A	Rattus norvegicus	52-55
1694105-2	1990	After prolonged administration of 2% sodium chloride as drinking water (salt-loading), the treatment increased the levels of VP, OXY, TH, GAL, DYN and CCK mRNA in the PVN and SON.	Water	65-70	cholecystokinin	Rattus norvegicus	151-154
2081254-3	1990	A positive association between a mother"s consumption of home tap water during the first trimester of pregnancy and cardiac anomalies in her infant was unrelated to the incident of water contamination, the mother"s race, or her educational level.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
28842602-2	2017	Here, the self-assembly mechanism of a peptide-perylenediimide (P-1) conjugate in mixed solvent systems of THF/water is studied and the semiconducting properties are correlated with the morphology.	Water	111-116	crystallin gamma F, pseudogene	Homo sapiens	64-67
1835320-2	1991	Recently, ANP-immunoreactivity has been detected in extracardial organs involved in water and electrolyte homeostasis, such as the intestine and certain exocrine glands.	Water	84-89	natriuretic peptide A	Rattus norvegicus	10-13
2065981-1	1991	Results of test stands and of field studies (on marine ships) have shown, that the use of installations for water preparation (IWP), including mineralizers of the wash out type and ozonizers, makes it possible to get water of stable quality independent of the terms of operations of the installations, and also provides the possibility of conditioning of shore water supply and of carrying out disinfection of the ship water supply system.	Water	108-113	inositol polyphosphate-5-phosphatase D	Homo sapiens	55-59
2184032-4	1990	We found that limited proteolysis of isolated nuclear envelopes with papain released a 200 kd water-soluble fragment of gp210 containing concanavalin A-reactive carbohydrate.	Water	94-99	nucleoporin 210	Homo sapiens	120-125
28784763-7	2017	We propose a mechanism whereby phosphorylation of AtPIP2;1 Ser121 by BAK1 and/or OST1 is triggered in response to flg22 to activate its water and H2O2 transport activities.	Water	136-141	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	50-58
1695691-4	1990	Urine output during CPB was not significantly different, but the total dose of furosemide administered was less in group Ul and a significant difference (p less than 0.05) was observed in the free water clearance at CPB 1 hr.	Water	197-202	carboxypeptidase B1	Homo sapiens	216-221
1895569-4	1991	EAU was successfully transferred by LN cells pre-cultured with IRBP, while EAU was poorly transferred by LN cells pre-cultured with Con A.	Water	0-3	retinol binding protein 3	Rattus norvegicus	63-67
1895569-5	1991	On the other hand, spleen cells pre-cultured with either IRBP or Con A were quite potent to transfer EAU.	Water	101-104	retinol binding protein 3	Rattus norvegicus	57-61
1895569-9	1991	The immune responses to IRBP in recipients with EAU were mostly cellular (delayed hypersensitivity type skin response and proliferative responses of lymphocytes), while humoral responses (Arthus type skin response and antibody activities) were quite weak in most of the recipients.	Water	48-51	retinol binding protein 3	Rattus norvegicus	24-28
28825640-5	2017	It was found that the grafting of PAM on xylan was conductive to improve xylan properties, such as the solubility in water, rheological features, and thermal stability, and the maximum grafting ratio was achieved to 14.7%.	Water	117-122	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	34-37
2176871-7	1990	We propose that the fourth ligand of Fea in substrate-free enzyme is a hydroxyl ion from the solvent; upon binding of substrate or substrate analogues at this Fea site, the solvent species becomes protonated to form a water molecule.	Water	218-223	FEA	Homo sapiens	37-40
2176871-7	1990	We propose that the fourth ligand of Fea in substrate-free enzyme is a hydroxyl ion from the solvent; upon binding of substrate or substrate analogues at this Fea site, the solvent species becomes protonated to form a water molecule.	Water	218-223	FEA	Homo sapiens	159-162
2392417-1	1990	Thermal inactivation of glucose-6-phosphate dehydrogenase (G6PDH) and its conjugates with progesterone containing 3, 7 and 35 molecules of the modifier was studied in bidistilled water over a temperature range 35-47 degrees.	Water	179-184	glucose-6-phosphate dehydrogenase	Homo sapiens	24-57
2392417-1	1990	Thermal inactivation of glucose-6-phosphate dehydrogenase (G6PDH) and its conjugates with progesterone containing 3, 7 and 35 molecules of the modifier was studied in bidistilled water over a temperature range 35-47 degrees.	Water	179-184	glucose-6-phosphate dehydrogenase	Homo sapiens	59-64
28801682-4	2017	We pooled data from two controlled studies where blood pressure (BP) and heart rate (HR) were continuously recorded before and after the ingestion of 355 mL of tap water.	Water	164-169	nuclear RNA export factor 1	Homo sapiens	160-163
24226348-10	1990	For example, a high-methionine, water-insoluble ASG is absent when the opaque-2 (o2) gene combines with shrunken-1 (sh1) or surgary-1 (su1).	Water	32-37	regulatory protein opaque-2	Zea mays	71-79
2076453-0	1990	Oscillatory reaction of alcohol dehydrogenase in an oil/water system.	Water	56-61	aldo-keto reductase family 1 member A1	Homo sapiens	24-45
28828260-8	2017	Results show that mTG sponges have uniform pore size, high porosity and water absorption, and good mechanical properties.	Water	72-77	protease, serine 3	Mus musculus	18-21
1963494-0	1990	Effect of atrial natriuretic factor and cyclic guanosine monophosphate on water and urea transport in the inner medullary collecting duct.	Water	74-79	natriuretic peptide A	Rattus norvegicus	10-35
1963494-1	1990	We examined the action of high (2 x 10(-8)M) and low (6 x 10(-9)M) concentrations of atrial natriuretic factor (ANF) on water and urea transport in the rat inner medullary collecting duct (IMCD) using the in vitro microperfusion technique.	Water	120-125	natriuretic peptide A	Rattus norvegicus	85-110
2158751-4	1990	Water-deprived rats presented significantly lower plasma ANF concentrations (22.0 +/- 1.9 vs. 34.4 +/- 3.8 fmol/ml, P less than 0.01) and an increase in total receptor density (1,860 +/- 398 vs. 987 +/- 143 fmol/mg protein) as compared with the control group.	Water	0-5	natriuretic peptide A	Rattus norvegicus	57-60
28642370-8	2017	Spectral titrations with cholesterol, in the presence of EFV or l-Glu, suggest that water displacement from the heme iron can be affected in activator-bound CYP46A1.	Water	84-89	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	157-164
2333972-1	1990	Neurotensin (NT), given intracerebroventricularly (icv), attenuates cold water restraint (CWR)-induced gastric mucosal injury; however, it is not clear which brain nuclear group or groups are involved.	Water	73-78	neurotensin	Rattus norvegicus	0-11
2140687-0	1990	Atrial natriuretic peptide in the subfornical organ reduces drinking induced by angiotensin or in response to water deprivation.	Water	110-115	natriuretic peptide A	Rattus norvegicus	0-26
2261054-11	1990	The other half of the Pseudomonads plus the Flexibacter species were mesotrophic oligocarbotolerants, since they could grow in tap water and in culture media with very high nutrient content.	Water	131-136	nuclear RNA export factor 1	Homo sapiens	127-130
1973159-5	1990	The data derived from biochemical investigations indicate that biochemistry of the cataractous Cat-2t lenses is affected: the osmotic state as indicated by the increased water content and increased Na(+)-K(+)-adenosinetriphosphatase (ATPase) activity; the energy state as indicated by the decreased adenosine triphosphate (ATP) concentration; and the redox state as indicated by the enhanced content of oxidized glutathione.	Water	170-175	dominant cataract 2	Mus musculus	95-100
1973159-6	1990	Additionally, the lenticular protein composition is altered because of the presence of vimentin in the water-soluble fraction.	Water	103-108	vimentin	Mus musculus	87-95
2140687-3	1990	Drinking in response to water deprivation was reduced by ANP in rats having cannulas in or near the SFO, but not in rats having cannulas distant from the SFO or in the ventricles.	Water	24-29	natriuretic peptide A	Rattus norvegicus	57-60
2140687-5	1990	The SFO may mediate the central effects of ANP on drinking induced by angiotensin or in response to water deprivation and could play a similar role in the central effects of ANP on salt appetite, diuresis, vasopressin secretion, and blood pressure.	Water	100-105	natriuretic peptide A	Rattus norvegicus	43-46
28455098-10	2017	We also observe that AQP4, that is particularly rich in the central nervous system, is more efficient in water conduction and more temperature-sensitive than other water-only channels (excluding glycerol channels that also conduct water when not inhibited by glycerol).	Water	105-110	aquaporin 4	Homo sapiens	21-25
2143001-0	1990	Effect of atrial natriuretic peptide on ischemic brain edema: changes in brain water and electrolytes.	Water	79-84	natriuretic peptide A	Rattus norvegicus	10-36
2143001-1	1990	The effects of intraventricularly administered atrial natriuretic peptide (ANP) on the brain water, sodium, and potassium contents in ischemic brain edema were investigated.	Water	93-98	natriuretic peptide A	Rattus norvegicus	47-73
2143001-1	1990	The effects of intraventricularly administered atrial natriuretic peptide (ANP) on the brain water, sodium, and potassium contents in ischemic brain edema were investigated.	Water	93-98	natriuretic peptide A	Rattus norvegicus	75-78
28455098-10	2017	We also observe that AQP4, that is particularly rich in the central nervous system, is more efficient in water conduction and more temperature-sensitive than other water-only channels (excluding glycerol channels that also conduct water when not inhibited by glycerol).	Water	164-169	aquaporin 4	Homo sapiens	21-25
2143001-9	1990	The present results reveal that, in ischemic brain edema, ANP may act directly on the central nervous system to inhibit brain water and sodium accumulation.	Water	126-131	natriuretic peptide A	Rattus norvegicus	58-61
28455098-10	2017	We also observe that AQP4, that is particularly rich in the central nervous system, is more efficient in water conduction and more temperature-sensitive than other water-only channels (excluding glycerol channels that also conduct water when not inhibited by glycerol).	Water	164-169	aquaporin 4	Homo sapiens	21-25
2145947-1	1990	Atrial natriuretic peptide (ANP), which was discovered from rat atria, has been implicated in the regulation of systemic water and electrolyte balances.	Water	121-126	natriuretic peptide A	Rattus norvegicus	0-26
2145947-1	1990	Atrial natriuretic peptide (ANP), which was discovered from rat atria, has been implicated in the regulation of systemic water and electrolyte balances.	Water	121-126	natriuretic peptide A	Rattus norvegicus	28-31
2189688-3	1990	In this study, a defined 16-mer uveitogenic interphotoreceptor retinoid binding protein (IRBP) peptide, designated #896, was used to induce EAU.	Water	140-143	retinol binding protein 3	Rattus norvegicus	44-87
28267649-2	2017	METHODS: EAU was induced in female B10.RIII mice by Inter-Photoreceptor-Binding-Protein (IRBP) in complete Freund"s adjuvant, boosted by Pertussis toxin.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	89-93
2189688-3	1990	In this study, a defined 16-mer uveitogenic interphotoreceptor retinoid binding protein (IRBP) peptide, designated #896, was used to induce EAU.	Water	140-143	retinol binding protein 3	Rattus norvegicus	89-93
2141422-15	1990	Finally, the kidneys of HYPOX rats are capable of increasing sodium and water output in response to large doses of exogenous ANF.	Water	72-77	natriuretic peptide A	Rattus norvegicus	125-128
28267649-13	2017	EAU activity correlates with ocular IL-6 and IL-17 levels.	Water	0-3	interleukin 17A	Mus musculus	45-50
2206462-3	1990	Two weeks later, treatment was started with 10% ethanol + 10% sucrose solution, 10% sucrose solution, or tap water as drinking water for 6 weeks with or without intraperitoneal injection of porcine serum twice a week.	Water	109-114	USO1 vesicle transport factor	Rattus norvegicus	105-108
28482324-1	2017	Exposure to pre-concentrated inlet or outlet STP wastewater extracts at different concentrations (0.001% to 1%) induced dose-dependent toxicity in MCF-7 cells, whereas drinking water extracts did not induce cytotoxicity in cells treated.	Water	54-59	thyroid hormone receptor interactor 10	Homo sapiens	45-48
2359758-3	1990	On raising the CSF pH, water intake increased in all three observations.	Water	23-28	colony stimulating factor 2	Rattus norvegicus	15-18
2104489-6	1990	Extracted by CHCl3:CH3OH:H2O (2:2:1.8), separated by thin layer chromatography (TLC) and determined by liquid scintillation counting, PAF released was inhibited significantly by Dau both in time (10-30 min) and dose (1-1000 mumol/L) dependent manners.	Water	25-28	patchy fur	Mus musculus	134-137
2346149-6	1990	While interventions exist for tap water scalds, solutions to the problems of "kitchen" scald and gasoline-involved flame burns are less apparent.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
28646315-6	2017	The AtCBF3 lines limited the water status-mediated hypersensitive response by lowering leaf osmotic potential due to overexpression of AtCBF3 under chilling stress.	Water	29-34	dehydration response element B1A	Arabidopsis thaliana	4-10
2380302-5	1990	Recoveries of greater than 90% were obtained when tap water was spiked with warfarin.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
16667357-3	1990	When a small incision in the base of the lip is made prior to emasculation, or when the lip is excised and placed in water within 10 to 15 hours after emasculation, coloration is considerably delayed.	Water	117-122	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	88-91
28646315-6	2017	The AtCBF3 lines limited the water status-mediated hypersensitive response by lowering leaf osmotic potential due to overexpression of AtCBF3 under chilling stress.	Water	29-34	dehydration response element B1A	Arabidopsis thaliana	135-141
28774628-8	2017	After adjusting by these personal determinants, a dose-response relationship was found between concentrations of all chemicals except aluminium in tap water and bottled water use.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
2339253-0	1990	Health impact evaluation of improved water supplies and hygiene practices in Sri Lanka: background and methodology.	Water	37-42	sorcin	Homo sapiens	77-80
2339984-2	1990	On Northern-blot analysis with gene-specific oligonucleotide probes, the steady-state mRNA levels of S1, S2, S3, K1 and P1 were all dramatically altered in the SMG of male and female rats treated with propylthiouracil (PTU; 100 mg/litre of drinking water) or thyroxine (T4; 10 micrograms/100 mg body wt.)	Water	249-254	keratin 1	Rattus norvegicus	113-122
28774628-10	2017	CONCLUSION: More than half of Barcelona residents regularly drank bottled water, and the main determinant was the chemical composition of tap water, particularly THM level.	Water	142-147	nuclear RNA export factor 1	Homo sapiens	138-141
2364574-10	1990	The direct hydration of the skin is of short duration and comparable to a tap-water bath.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
28764372-3	2017	Using computer simulations of the ST2 water model, we study how the sharpness of the compression-induced transition from low-density amorphous ice (LDA) to high-density amorphous ice (HDA) is influenced by the preparation of LDA.	Water	38-43	ST2	Homo sapiens	34-37
2321644-4	1990	Our fluids are prepared from fluoridated tap water that is purified by reverse osmosis (RO).	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
2321644-6	1990	Since many HD units rely on RO systems to purify fluoridated tap water, it is likely that many HD patients are being exposed inadvertently to increased concentrations of fluoride.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
1707307-9	1990	An amount of approximately 0.5 g H2O/g protein could be assigned to the BPTI.	Water	33-36	spleen trypsin inhibitor I	Bos taurus	72-76
28654236-0	2017	Closed Bipolar Electrodes for Spatial Separation of H2 and O2 Evolution during Water Electrolysis and the Development of High-Voltage Fuel Cells.	Water	79-84	relaxin 2	Homo sapiens	52-61
18964929-6	1990	The gallium content found in tap water was higher than that in raw water.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
2138426-8	1990	These results indicate that ANP plays a physiological role in the regulation of urinary water and sodium excretion after pulmonary acid injury and suggest that ANP elevated in plasma after pulmonary injury may prevent pulmonary edema with its diuretic action and/or some direct action on water movement in the lung.	Water	88-93	natriuretic peptide A	Rattus norvegicus	28-31
2138426-8	1990	These results indicate that ANP plays a physiological role in the regulation of urinary water and sodium excretion after pulmonary acid injury and suggest that ANP elevated in plasma after pulmonary injury may prevent pulmonary edema with its diuretic action and/or some direct action on water movement in the lung.	Water	288-293	natriuretic peptide A	Rattus norvegicus	28-31
2138426-8	1990	These results indicate that ANP plays a physiological role in the regulation of urinary water and sodium excretion after pulmonary acid injury and suggest that ANP elevated in plasma after pulmonary injury may prevent pulmonary edema with its diuretic action and/or some direct action on water movement in the lung.	Water	288-293	natriuretic peptide A	Rattus norvegicus	160-163
2153026-6	1990	It is also suggested that the amino acids at the distal region of P-450d may be located close to the heme, so that the water molecule cannot bind to the heme, thus taking the high-spin state.	Water	119-124	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	66-72
28654236-2	2017	However, as H2 and O2 are produced in close proximity to each other in water electrolyzers, mixing of the gases can occur during electrolysis, with potentially dangerous consequences.	Water	71-76	relaxin 2	Homo sapiens	12-21
28654236-5	2017	Electrolytic water splitting occurs in tandem with oxidation/reduction of the K3Fe(CN)6/K4Fe(CN) redox couples in the separate compartments, affording completely spatially separated H2 and O2 evolution.	Water	13-18	relaxin 2	Homo sapiens	182-191
2141814-0	1990	Atrial natriuretic factor in central nervous system regulatory mechanisms: effect of experimental alterations in water and salt homeostasis and blood pressure.	Water	113-118	natriuretic peptide A	Rattus norvegicus	0-25
28695935-1	2017	Spin-polarized density functional theory calculations (GGA+U) and atomic thermodynamics have been used to study the adsorption of water on the CuO(011) surface at different coverages.	Water	130-135	spindlin 1	Homo sapiens	0-4
2361823-4	1990	of 3.1 +/- 1.4 ng/ml (normal less than 0.5 ng/ml); elevated home tap-water aluminium levels of 6.5 +/- 1.2 umol/l (normal less than 2 umol/l); and a GFR of 20.5 mls/min/1.73m, (range 2-50 mls/min/1.73m).	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
1982483-4	1990	We conclude that the increase in brain water content is linked to the glutamine accumulation derived from the detoxification of ammonia by glutamine synthetase.	Water	39-44	glutamate-ammonia ligase	Rattus norvegicus	139-159
2089900-6	1990	The relative contributions of the osmotic force produced by the increase in brain cations and the oncotic force produced by the increase in brain albumin to the observed change in water content were calculated.	Water	180-185	albumin	Rattus norvegicus	146-153
2142916-12	1990	Infusion of ANF into chronic renal denervated rats also reduced the blood pressure and increased the renal excretion of water and sodium.	Water	120-125	natriuretic peptide A	Rattus norvegicus	12-15
24196310-3	1990	Decay rates of the phage (UT1) ranged from 0.054 hour(-1) in natural water to 0.027 hour(-1) in filtered lake water.	Water	69-74	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	26-29
28720105-14	2017	Moreover, it is necessary to comprehensively promote the flush toilets and tap water in rural areas.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
24196310-3	1990	Decay rates of the phage (UT1) ranged from 0.054 hour(-1) in natural water to 0.027 hour(-1) in filtered lake water.	Water	110-115	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	26-29
24196310-4	1990	About 45% of sensitive bacteria incubated with phase UT1 were pseudolysogenic within 12 hours of incubation in natural lake water.	Water	124-129	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	53-56
24196310-6	1990	Phage UT1 appeared to stabilize the density of host bacteria in lake water at a level of 10(4) colony-forming units (cfu) ml(-1).	Water	69-74	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	6-9
2153070-0	1990	Monoamine oxidase B inhibition reduces gastric mucosal blood flow, basal acid secretion, and cold water restraint-induced gastric mucosal injury in rats.	Water	98-103	monoamine oxidase B	Rattus norvegicus	0-19
2153070-1	1990	Inhibition of monoamine oxidase B (MAO B) by selective inhibitors pargyline and L-deprenyl increases dopamine (DA) and norepinephrine (NE) concentrations in nucleus accumbens (NACB) and is associated with reduction in cold water restraint-induced gastric mucosal injury, inhibition of basal gastric acid output, and regional gastric mucosal blood flow.	Water	223-228	monoamine oxidase B	Rattus norvegicus	14-33
2153070-1	1990	Inhibition of monoamine oxidase B (MAO B) by selective inhibitors pargyline and L-deprenyl increases dopamine (DA) and norepinephrine (NE) concentrations in nucleus accumbens (NACB) and is associated with reduction in cold water restraint-induced gastric mucosal injury, inhibition of basal gastric acid output, and regional gastric mucosal blood flow.	Water	223-228	monoamine oxidase B	Rattus norvegicus	35-40
28457444-6	2017	Water stability test confirmed that the photocrosslinked matrix with a MCS/MPVA ratio of 10/90 retained excellent integrity of the fibrous structure in water.	Water	0-5	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	71-74
2298638-10	1990	For the model calculations performed the best ratio of fat to muscle SAR (0.2) is obtained with distilled water as bolus medium in the gap.	Water	106-111	sarcosine dehydrogenase	Homo sapiens	69-72
2328231-1	1990	Upon removal of the heme group, the water-soluble fragment of cytochrome b5 adopts a conformation less stable and compact than that of the holoprotein [Huntley, T. E., &amp; Strittmatter, P. (1972) J. Biol.	Water	36-41	cytochrome b5 type A	Rattus norvegicus	62-75
28457444-6	2017	Water stability test confirmed that the photocrosslinked matrix with a MCS/MPVA ratio of 10/90 retained excellent integrity of the fibrous structure in water.	Water	152-157	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	71-74
2311265-3	1990	Fibroblasts from patients with propionyl CoA carboxylase, and to a lesser extent from patients with methylmalonyl CoA mutase defects, show reductions in the amount of CO2 released, although the production of water-soluble metabolites is not affected.	Water	208-213	methylmalonyl-CoA mutase	Homo sapiens	100-124
2311295-7	1990	A second rise of C3a levels and C3a:C3 ratio from day 4 on paralleled the course of extravascular lung water.	Water	103-108	complement C3	Homo sapiens	17-20
2311295-7	1990	A second rise of C3a levels and C3a:C3 ratio from day 4 on paralleled the course of extravascular lung water.	Water	103-108	complement C3	Homo sapiens	32-35
2079994-7	1990	It was found that the tap water from Kanagawa prefecture, Japan, had the highest V concentrations among the 21 cities in Japan and the US.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
28593758-4	2017	Owing to its large contact angle and low-adhesive force on the superhydrophobic substrate, the colloidal suspension exhibits a continuous retraction of the three-phase (gas-liquid-solid) contact line (TCL) in the process of solvent (water molecules) evaporation.	Water	233-238	ras homolog family member J	Homo sapiens	201-204
2137083-2	1990	A 1985 study linked ingestion of aldicarb-contaminated drinking water with altered T-cell distributions, specifically an increase in the mean number of CD8+ (T8) T cells.	Water	64-69	CD8a molecule	Homo sapiens	152-155
28593758-5	2017	The constantly receding TCL can bring the colloidal spheres closer to each other, which could timely close the gaps due to the loss of water molecules.	Water	135-140	ras homolog family member J	Homo sapiens	24-27
27628187-3	2017	This paper reports application of a panel of quantitative assays developed to analyze and characterize an oil-in-water adjuvant emulsion, which contains glucopyranosyl lipid A (GLA) and is a squalene-based emulsion.	Water	113-118	galactosidase alpha	Homo sapiens	177-180
2156051-10	1990	An increase in osmolality of the incubation media decreased OT-stimulated PI hydrolysis in LLC-PK1 and abolished completely the effect of OT at 1200 mOsmol/kg of H2O.	Water	162-165	oxytocin/neurophysin I prepropeptide	Sus scrofa	60-62
2156051-10	1990	An increase in osmolality of the incubation media decreased OT-stimulated PI hydrolysis in LLC-PK1 and abolished completely the effect of OT at 1200 mOsmol/kg of H2O.	Water	162-165	oxytocin/neurophysin I prepropeptide	Sus scrofa	138-140
33940232-1	2021	Neuromyelitis optica spectrum disorders (NMOSD) are characterised by pathological antibodies to aquaporin-4 water channels of astrocytes, resulting in severe brain and spinal cord injury.	Water	108-113	aquaporin 4	Homo sapiens	96-107
28580549-11	2017	Furthermore, changes of the water"s features could disturb the balance of Hg2+-Cl--SO32- systems, which might stimulate the decomposition of ClHgSO3.	Water	28-33	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	74-77
33971986-9	2021	Hpa-tg brains presented with thicker VBMs and swollen perivascular astrocyte endfeet, as well as elevated expression of the BBB-associated water-pump protein aquaporin 4 (AQP4).	Water	139-144	aquaporin 4	Mus musculus	158-169
33971986-9	2021	Hpa-tg brains presented with thicker VBMs and swollen perivascular astrocyte endfeet, as well as elevated expression of the BBB-associated water-pump protein aquaporin 4 (AQP4).	Water	139-144	aquaporin 4	Mus musculus	171-175
2151009-1	1990	We investigated the effect of intraventricularly administered atrial natriuretic peptide (ANP) on the brain water, sodium and potassium contents in ischaemic brain oedema.	Water	108-113	natriuretic peptide A	Rattus norvegicus	62-88
2073131-11	1990	Finally, soman could be detected in different biological samples like human serum, goat serum, rabbit serum, chicken serum, milk, and tap water in concentrations between 1.3 x 10(-6) and 2.0 x 10(-6) mol/l.	Water	138-143	nuclear RNA export factor 1	Homo sapiens	134-137
28563699-2	2017	A previous study on the neutron crystal structure of TTR suggested that a large hydrogen bond network around H88 which includes water molecules is significantly involved in the stability of wild-type TTR (WT-TTR).	Water	128-133	transthyretin	Homo sapiens	53-56
2328293-4	1990	A CD study of (13-36)PYY in mixed H2O and trifluoroethanol (TFE) solutions indicated a significant increase in alpha-helical segments (26-79%) with increasing TFE proportions.	Water	34-37	peptide YY	Rattus norvegicus	21-24
33970943-4	2021	The number of collision accidents per unit time in a certain water area can be considered to describe the regional collision risk However, historical ship collision accidents have contingencies, small sample sizes and weak regularities; hence, ship collision conflicts can be used as a substitute for ship collision accidents in characterizing the maritime traffic safety situation and have become an important part of methods that quantitatively study the traffic safety problem and its countermeasures.	Water	61-66	inositol polyphosphate-5-phosphatase D	Homo sapiens	150-154
33970943-4	2021	The number of collision accidents per unit time in a certain water area can be considered to describe the regional collision risk However, historical ship collision accidents have contingencies, small sample sizes and weak regularities; hence, ship collision conflicts can be used as a substitute for ship collision accidents in characterizing the maritime traffic safety situation and have become an important part of methods that quantitatively study the traffic safety problem and its countermeasures.	Water	61-66	inositol polyphosphate-5-phosphatase D	Homo sapiens	244-248
33970943-4	2021	The number of collision accidents per unit time in a certain water area can be considered to describe the regional collision risk However, historical ship collision accidents have contingencies, small sample sizes and weak regularities; hence, ship collision conflicts can be used as a substitute for ship collision accidents in characterizing the maritime traffic safety situation and have become an important part of methods that quantitatively study the traffic safety problem and its countermeasures.	Water	61-66	inositol polyphosphate-5-phosphatase D	Homo sapiens	244-248
33811631-4	2021	Microplastics in tap water were related to materials of transportation pipelines in drinking-water supply chain.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
28563699-2	2017	A previous study on the neutron crystal structure of TTR suggested that a large hydrogen bond network around H88 which includes water molecules is significantly involved in the stability of wild-type TTR (WT-TTR).	Water	128-133	transthyretin	Homo sapiens	200-203
33811631-4	2021	Microplastics in tap water were related to materials of transportation pipelines in drinking-water supply chain.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	17-20
1701375-8	1990	Deprivation of water for 2 and 4 days increased ANP-mRNA 2.1- and 1.6-fold, respectively.	Water	15-20	natriuretic peptide A	Rattus norvegicus	48-51
28563699-2	2017	A previous study on the neutron crystal structure of TTR suggested that a large hydrogen bond network around H88 which includes water molecules is significantly involved in the stability of wild-type TTR (WT-TTR).	Water	128-133	transthyretin	Homo sapiens	200-203
1701375-10	1990	These results demonstrated that water-salt balance affects the ANP-gene expression.	Water	32-37	natriuretic peptide A	Rattus norvegicus	63-66
28563699-5	2017	Our results suggest that in some cases TTR is destabilized due to alterations in bound water molecules as well as structural changes in TTR itself.	Water	87-92	transthyretin	Homo sapiens	39-42
33816773-8	2021	Results  In vitr o , 20 mL of tap water was injected once into the forceps channel and then aspirated for 10 seconds.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
33940881-7	2021	At 2000 m water depth, although the acoustic signal of the ship is more attenuated, signals below 50 Hz are detected.	Water	10-15	inositol polyphosphate-5-phosphatase D	Homo sapiens	59-63
28242261-0	2017	Specific interactions between vitamin-D receptor and its ligands: Ab initio molecular orbital calculations in water.	Water	110-115	vitamin D receptor	Homo sapiens	30-48
33940904-1	2021	A method is presented for estimating the range of a distant ship in shallow water using a vertical array and a guide ship at a known range close to the array.	Water	76-81	inositol polyphosphate-5-phosphatase D	Homo sapiens	60-64
33940904-7	2021	The proposed method is demonstrated using a ship of opportunity radiating broadband noise (100-500 Hz) and a 56.25-m long vertical array in approximately 100-m water.	Water	160-165	inositol polyphosphate-5-phosphatase D	Homo sapiens	44-48
2243598-4	1990	In addition, release of acetylcholinesterase could be evoked by either pharmacological or physiological manipulations, i.e. (1) a depolarizing concentration of potassium ions administered locally; (2) metamphetamine, administered systematically, which also resulted in increased locomotor activity; (3) drinking behaviour, elicited by presentation of a water bottle.	Water	353-358	acetylcholinesterase	Cavia porcellus	24-44
2340766-0	1990	[Effects of Cr+6-polluted-well-water on inhabitant"s health].	Water	31-36	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	12-16
2340766-1	1990	The increase of Cr+6 in well water results from pollution by electroplating waste water.	Water	29-34	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	16-20
2340766-1	1990	The increase of Cr+6 in well water results from pollution by electroplating waste water.	Water	82-87	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	16-20
27405469-9	2017	In addition, administration of IL-33 alleviated cerebral water contents, reduced the number of PI- and TUNEL-positive cells, and improved neurological function after ICH.	Water	57-62	interleukin 33	Mus musculus	31-36
2340766-2	1990	The average content of Cr+6 in water of the wells in the polluted area is as high as 1.68 mumols/L, obviously higher than that in the control area (P less than 0.05).	Water	31-36	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	23-27
33971104-6	2022	To evaluate the possible association of skin cancer with source of tap water, we calculated odds ratios for participants with melanoma and nonmelanoma skin cancer, compared with participants with no cancer.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
33818445-2	2021	When electrolysis was performed for 10 minutes using a direct-current electrolytic hydrogen-water generating bottle with tap water, "residual free chlorine" concurrently upon the production of molecular hydrogen (444 mug/L) could be appreciably decreased from 0.18 mg/L to 0.12 mg/L as quantified by a N,N-diethyl-p-phenylenediamine-dye colorimetric method.	Water	92-97	nuclear RNA export factor 1	Homo sapiens	121-124
33818445-2	2021	When electrolysis was performed for 10 minutes using a direct-current electrolytic hydrogen-water generating bottle with tap water, "residual free chlorine" concurrently upon the production of molecular hydrogen (444 mug/L) could be appreciably decreased from 0.18 mg/L to 0.12 mg/L as quantified by a N,N-diethyl-p-phenylenediamine-dye colorimetric method.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
33818445-7	2021	Importantly, even when half the amount of tap water was poured into the tank of the apparatus and electrolyzed, both the residual chlorine and ozone concentrations measured were also below the safety standard.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Water	234-239	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Water	234-239	ATP binding cassette subfamily B member 11	Homo sapiens	109-115
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Water	234-239	ATP binding cassette subfamily C member 2	Homo sapiens	150-154
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Water	234-239	ATP binding cassette subfamily C member 2	Homo sapiens	155-160
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Water	110-115	ATP binding cassette subfamily B member 11	Homo sapiens	174-178
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Water	110-115	ATP binding cassette subfamily B member 11	Homo sapiens	179-185
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Water	110-115	ATP binding cassette subfamily C member 2	Homo sapiens	190-194
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Water	110-115	ATP binding cassette subfamily C member 2	Homo sapiens	195-200
33805879-0	2021	Knockout of Auxin Response Factor SlARF4 Improves Tomato Resistance to Water Deficit.	Water	71-76	auxin response factor 4	Solanum lycopersicum	34-40
33805879-2	2021	In this study, SlARF4, a member of the ARF family, was functionally characterized under water deficit.	Water	88-93	auxin response factor 4	Solanum lycopersicum	15-21
33805239-3	2021	This article presents the results of the experiments with application of the selected control methods in automatic steering of the movement of an autonomous ship in the two regimes: during the maneuvers at low speed (in a harbor confined waters) and during the lake trials in open water conditions.	Water	238-243	inositol polyphosphate-5-phosphatase D	Homo sapiens	157-161
33809867-7	2021	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.	Water	84-89	elastin	Homo sapiens	24-31
33776426-0	2021	Water-Soluble Chitosan Conjugated DOTA-Bombesin Peptide Capped Gold Nanoparticles as a Targeted Therapeutic Agent for Prostate Cancer.	Water	0-5	gastrin releasing peptide	Homo sapiens	39-47
33815893-0	2021	Electrocatalytic Water Oxidation with alpha-[Fe(mcp)(OTf)2] and Analogues.	Water	17-22	POU class 2 homeobox 2	Homo sapiens	53-58
33765801-5	2021	The proposed method is tested using real acoustic data recorded from a bottom-mounted linear array of eight hydrophones, for six transits of a small ship and a single transit of a rigid-hulled inflatable boat in shallow water.	Water	220-225	ataxin 1 like	Homo sapiens	204-208
33034320-4	2020	In this study, we developed a matrix metalloproteinase-2 (MMP-2) activatable nanoprobe (PEG-PepMMP2-MNP-Gd), which was composed of water-insoluble gadolinium-chelated melanin (MNP-Gd), MMP-2 cleaved peptide and enzymatic detachable polyethylene glycol (PEG).	Water	131-136	matrix metallopeptidase 2	Mus musculus	30-56
33034320-4	2020	In this study, we developed a matrix metalloproteinase-2 (MMP-2) activatable nanoprobe (PEG-PepMMP2-MNP-Gd), which was composed of water-insoluble gadolinium-chelated melanin (MNP-Gd), MMP-2 cleaved peptide and enzymatic detachable polyethylene glycol (PEG).	Water	131-136	matrix metallopeptidase 2	Mus musculus	58-63
28228712-0	2016	Nordic Walking and the Isa Method for Breast Cancer Survivors: Effects on Upper Limb Circumferences and Total Body Extracellular Water - a Pilot Study.	Water	129-134	annexin A13	Homo sapiens	23-26
28228712-5	2016	RESULTS: 10 lessons on Nordic walking technique plus the Isa method significantly reduced both extracellular body water and the extracellular-to-total body water ratio (p = 0.01 for both), and also the circumference of the upper limb, (both relaxed arm and forearm circumferences) (p = 0.01 for all), whereas Nordic walking alone did not.	Water	114-119	annexin A13	Homo sapiens	57-60
28228712-5	2016	RESULTS: 10 lessons on Nordic walking technique plus the Isa method significantly reduced both extracellular body water and the extracellular-to-total body water ratio (p = 0.01 for both), and also the circumference of the upper limb, (both relaxed arm and forearm circumferences) (p = 0.01 for all), whereas Nordic walking alone did not.	Water	156-161	annexin A13	Homo sapiens	57-60
25212173-4	2014	This behaviour could be due to the decrease in viscosity when the permeant was changed from tap water to leachate.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
18495879-6	2008	This is the first direct comparison of ECS properties in adult mice lacking AQP4 water channels with wild-type animals and demonstrates a significant enlargement of the volume fraction but no difference in hindrance to TMA(+) diffusion, expressed as tortuosity.	Water	81-86	aquaporin 4	Mus musculus	76-80
18985050-1	2009	Aquaporin 4 (AQP4) is a water channel involved in water movements across the cell membrane and is spatially organized on the cell surface in orthogonal array particles (OAPs).	Water	24-29	aquaporin 4	Mus musculus	0-11
18985050-1	2009	Aquaporin 4 (AQP4) is a water channel involved in water movements across the cell membrane and is spatially organized on the cell surface in orthogonal array particles (OAPs).	Water	24-29	aquaporin 4	Mus musculus	13-17
18985050-1	2009	Aquaporin 4 (AQP4) is a water channel involved in water movements across the cell membrane and is spatially organized on the cell surface in orthogonal array particles (OAPs).	Water	50-55	aquaporin 4	Mus musculus	0-11
18985050-1	2009	Aquaporin 4 (AQP4) is a water channel involved in water movements across the cell membrane and is spatially organized on the cell surface in orthogonal array particles (OAPs).	Water	50-55	aquaporin 4	Mus musculus	13-17
34619120-9	2022	The practicality of the proposed probe was evaluated by quantifying cyanide in tap water and soils and monitoring the liberation of hydrogen cyanide from cyanogenic glycoside-containing foods.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
34753075-1	2022	Poor water solubility and stability of beta-carotene (Car) greatly hinder its application in foods.	Water	5-10	nuclear receptor subfamily 1 group I member 3	Homo sapiens	54-57
34753075-5	2022	Compared with free Car, Car/OA NPs exhibited significantly improved water dispersibility and enhanced stability against UV radiation, heat, ionic strength, and acidic conditions.	Water	68-73	nuclear receptor subfamily 1 group I member 3	Homo sapiens	24-27
34811794-1	2022	PURPOSE: The paper introduces a classical model to describe the dynamics of large spin-1/2 ensembles associated with nuclei bound in large molecule structures, commonly referred to as the semi-solid spin pool, and their magnetization transfer (MT) to spins of nuclei in water.	Water	270-275	spindlin 1	Homo sapiens	82-90
34952273-5	2022	Accordingly, using the catalyst as anode, the home-assembled S-FeNi LDH@PBA/NF//Pt/C/NF electrolyzer exhibited small Tafel slope (83.1 mV dec-1) and ultra-stability, showing the potential feasibility in practical water electrolysis.	Water	213-218	neurofascin	Homo sapiens	76-78
34952273-5	2022	Accordingly, using the catalyst as anode, the home-assembled S-FeNi LDH@PBA/NF//Pt/C/NF electrolyzer exhibited small Tafel slope (83.1 mV dec-1) and ultra-stability, showing the potential feasibility in practical water electrolysis.	Water	213-218	neurofascin	Homo sapiens	85-87
34896712-9	2022	We suggest that water potentiates the absorbing capacities of FE powder by intercalating between clay lamellas leading to the appearance of new adsorption zones and swelling.	Water	16-21	general transcription factor IIE subunit 1	Homo sapiens	62-64
33772424-2	2021	Recent studies have indicated that aquaporin 4 (AQP4), as a predominant water channel protein in the brain, is involved in the progression of Parkinson"s disease (PD).	Water	72-77	aquaporin 4	Mus musculus	35-46
33772424-2	2021	Recent studies have indicated that aquaporin 4 (AQP4), as a predominant water channel protein in the brain, is involved in the progression of Parkinson"s disease (PD).	Water	72-77	aquaporin 4	Mus musculus	48-52
33805879-3	2021	Real-time fluorescence quantitative polymerase chain reaction (PCR) and beta-glucuronidase (GUS) staining showed that water deficit and abscisic acid (ABA) treatment reduced the expression of SlARF4.	Water	118-123	auxin response factor 4	Solanum lycopersicum	192-198
33805879-5	2021	Loss of function of SlARF4 (arf4) by using Clustered Regularly Interspaced Short Palindromic Repeats/Cas 9 (CRISPR/Cas 9) technology enhanced plant resistance to water stress and rehydration ability.	Water	162-167	auxin response factor 4	Solanum lycopersicum	20-26
33805879-5	2021	Loss of function of SlARF4 (arf4) by using Clustered Regularly Interspaced Short Palindromic Repeats/Cas 9 (CRISPR/Cas 9) technology enhanced plant resistance to water stress and rehydration ability.	Water	162-167	auxin response factor 4	Solanum lycopersicum	28-32
33805879-9	2021	We identified 628 differentially expressed genes specifically expressed under water deficit in arf4 mutants; six of these genes, including ABA signaling pathway-related genes, were differentially expressed between the wildtype and arf4 mutants under water deficit and unlimited water supply.	Water	78-83	auxin response factor 4	Solanum lycopersicum	95-99
33805879-9	2021	We identified 628 differentially expressed genes specifically expressed under water deficit in arf4 mutants; six of these genes, including ABA signaling pathway-related genes, were differentially expressed between the wildtype and arf4 mutants under water deficit and unlimited water supply.	Water	78-83	auxin response factor 4	Solanum lycopersicum	231-235
33805879-9	2021	We identified 628 differentially expressed genes specifically expressed under water deficit in arf4 mutants; six of these genes, including ABA signaling pathway-related genes, were differentially expressed between the wildtype and arf4 mutants under water deficit and unlimited water supply.	Water	250-255	auxin response factor 4	Solanum lycopersicum	95-99
33805879-9	2021	We identified 628 differentially expressed genes specifically expressed under water deficit in arf4 mutants; six of these genes, including ABA signaling pathway-related genes, were differentially expressed between the wildtype and arf4 mutants under water deficit and unlimited water supply.	Water	250-255	auxin response factor 4	Solanum lycopersicum	231-235
33805879-9	2021	We identified 628 differentially expressed genes specifically expressed under water deficit in arf4 mutants; six of these genes, including ABA signaling pathway-related genes, were differentially expressed between the wildtype and arf4 mutants under water deficit and unlimited water supply.	Water	250-255	auxin response factor 4	Solanum lycopersicum	95-99
33805879-9	2021	We identified 628 differentially expressed genes specifically expressed under water deficit in arf4 mutants; six of these genes, including ABA signaling pathway-related genes, were differentially expressed between the wildtype and arf4 mutants under water deficit and unlimited water supply.	Water	250-255	auxin response factor 4	Solanum lycopersicum	231-235
33805879-10	2021	Auxin responsive element (AuxRE) elements were found in these genes" promoters indicating that SlARF4 participates in ABA signaling pathways by regulating the expression of SlABI5/ABF and SCL3, thereby influencing stomatal morphology and vascular bundle development and ultimately improving plant resistance to water deficit.	Water	311-316	auxin response factor 4	Solanum lycopersicum	95-101
33816338-4	2021	In this study, a sensitive, specific, rapid, and simple molecular point of care testing for African swine fever virus (ASFV) B646L gene in blood samples was established, including treatment of blood samples with simple dilution and boiling for 5 min, isothermal amplification with recombinase-aided amplification (RAA) at 37 C in a water bath for 10 min, and visual readout with lateral flow assay (LFA) at room temperature for 10-15 min.	Water	332-337	structural protein p72	African swine fever virus	125-130
33803441-4	2021	Surprisingly, we found that CD4-IRF4KO mice are resistant to EAU.	Water	61-64	CD4 antigen	Mus musculus	28-31
33771955-1	2021	SIGNIFICANCE: This study provides insight into the current recommendations, clinical behaviors, and risk assessments of eye care professionals on the topic of rigid contact lens exposure to tap water.	Water	194-199	nuclear RNA export factor 1	Homo sapiens	190-193
33771955-3	2021	PURPOSE: The purpose of this study was to investigate the practice patterns and risk perceptions of eye care professionals regarding gas-permeable contact lens exposure to tap water.	Water	176-181	nuclear RNA export factor 1	Homo sapiens	172-175
33771955-5	2021	The survey queried participants about their current practices, recommendations, and perceptions of risk regarding exposure of gas-permeable contact lenses to tap water.	Water	162-167	nuclear RNA export factor 1	Homo sapiens	158-161
33771955-6	2021	RESULTS: Of those who prescribe gas-permeable contact lenses, 57.4% reported rinsing lenses with tap water, whereas only 32.7% reported engaging in this same behavior in front of patients.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
33771955-7	2021	Of those who reported never rinsing lenses with tap water, 85.6% indicated that rinsing lenses with water increases infection risk, whereas 52.1% of those who rinse lenses with water reported the same perceived risk (P < .001).	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
33587587-11	2021	In addition, when FeCoP2@NPPC was used as a bifunctional catalyst in water splitting, the electrolyzer needed a low voltage of 1.60 V to deliver the current density of 10 mA cm-2.	Water	69-74	natriuretic peptide C	Homo sapiens	18-29
33794518-10	2021	EG-VEGF, VEGFR2, VEGFR3, and VEGF-D can also explain the elevated blood pressure due to the dilated lymphatic system which drains excess sodium and water back into circulation.	Water	148-153	prokineticin 1	Homo sapiens	0-7
33774613-0	2020	Drinking Water and CKD of Unknown Etiology in Sri Lanka: A Community Perspective.	Water	9-14	sorcin	Homo sapiens	46-49
33774613-1	2020	People"s belief that polluted drinking water is the principal medium through which environmental toxins are absorbed into the bodies of CKD of unknown etiology (CKDu) patients in the CKDu-endemic areas in Sri Lanka has been the subject of extensive epidemiological and medical research.	Water	39-44	sorcin	Homo sapiens	205-208
30006087-2	2018	The water-soluble pectin (WSP) fraction, extracted with the Microwave Assisted Extraction (MAE), was further deproteinated (dWSP) and analyzed through several biophysical and biochemical techniques.	Water	4-9	WASp	Drosophila melanogaster	26-29
25267146-0	2015	Tap water iontophoresis may be ineffective for axillary hyperhidrosis.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
19631047-4	2009	Riboflavin (vitamin B-2) and pyridoxine (vitamin B-6) are similar to thiamin in that they are water-soluble, subject to renal excretion, have limited tissue storage, and are dependent on intake.	Water	94-99	immunoglobulin kappa variable 5-2	Homo sapiens	20-23
34969476-0	2022	Corrigendum to "Ecological niche and in-situ control of MIB producers in source water" Journal of Environmental Sciences 110 (2021) 119-128.	Water	80-85	MIB E3 ubiquitin protein ligase 1	Homo sapiens	56-59
34922077-5	2022	In particular, when Ru-NiCoP/NF is employed as both cathode and anode electrodes,a small voltage of 1.50 V is required to reach 30 mA cm-2for overall water splittingwith an impressive stability.	Water	150-155	neurofascin	Homo sapiens	29-31
34822902-8	2022	Target analysis of 110 PPCPs showed detection of 21, 19 and 22 compounds in the drinking water treatment plant with a concentration range of 0.11-844 ng/L in the three seasons, but only 8, 9 and 15 compounds detected in tap water (0.16-32.5 ng/L).	Water	224-229	nuclear RNA export factor 1	Homo sapiens	220-223
34822902-9	2022	The variations of the detected chemicals were less obvious in tap water, with most having concentrations below 2 ng/L.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
34634702-3	2022	As an emerging AOP, UV/chloramine process shows many noteworthy advantages in the scenario of potable water reuse, including membrane biological fouling control by chloramine, producing highly reactive radicals (e.g., Cl , HO , Cl2 -, and reactive nitrogen-containing species) to degrade the RO permeated pollutants, and acting as long-lasting disinfectant in the potable water distribution system.	Water	102-107	endogenous retrovirus group W member 5	Homo sapiens	228-231
34715559-5	2022	Nit1 is a small-molecular-mass compound (188 g mol-1) that is water-soluble and has specificity for sensing Cu2+ with an association constant of K = 1.53 x 1010 and a limit of detection (LOD) of 0.06 ppm.	Water	62-67	nitrilase 1	Homo sapiens	0-4
34906628-3	2022	We found that 5 x FAD transgenic mice treated with the synthetic GLP-1 receptor agonist exenatide had improved cognitive function per the Morris water maze test.	Water	145-150	glucagon-like peptide 1 receptor	Mus musculus	65-79
34847430-7	2022	A suitable water-octanol partition coefficient (logP, 0.521 +- 0.003) and low cytotoxicity displayed that NCR is very favorable to image living cells.	Water	11-16	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	106-109
34883127-8	2022	Moreover, by the established method, trace estrogenic activity (14.7-24.2 pg E2 equivalents (E2Eq)/L) can be detected in a portion of "clean" drinking water (Tap water) samples.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	158-161
34883127-8	2022	Moreover, by the established method, trace estrogenic activity (14.7-24.2 pg E2 equivalents (E2Eq)/L) can be detected in a portion of "clean" drinking water (Tap water) samples.	Water	162-167	nuclear RNA export factor 1	Homo sapiens	158-161
34893218-3	2022	Batches of experiments showed that (i) CSCA (33.39% of grafting degree), ODs, and C-ODs (100-200 mum in pore size) were synthesized, evidenced by FT-IR, 1H NMR, elemental analysis, hydroxylamine hydrochloride titration, and SEM results; (ii) among C-ODs, C-OD2 had appropriate porosity (85.0%), swelling (20 times its dry weight), absorption, water retention, water vapor transmission, and mechanical properties; (iii) C-OD2 possessed low toxicity (relative cell viability > 86%), low hemolysis rate (0.65%), suitable tissue adhesion (4.74 kPa), and strong antibacterial efficacy (five strains); and (iv) C-OD2"s dynamic blood clotting was within 30 s. In three animal injury models, C-OD2"s hemostasis time and blood loss were fairly lower than commercial gelatin sponge.	Water	343-348	COD2	Homo sapiens	255-260
34893218-3	2022	Batches of experiments showed that (i) CSCA (33.39% of grafting degree), ODs, and C-ODs (100-200 mum in pore size) were synthesized, evidenced by FT-IR, 1H NMR, elemental analysis, hydroxylamine hydrochloride titration, and SEM results; (ii) among C-ODs, C-OD2 had appropriate porosity (85.0%), swelling (20 times its dry weight), absorption, water retention, water vapor transmission, and mechanical properties; (iii) C-OD2 possessed low toxicity (relative cell viability > 86%), low hemolysis rate (0.65%), suitable tissue adhesion (4.74 kPa), and strong antibacterial efficacy (five strains); and (iv) C-OD2"s dynamic blood clotting was within 30 s. In three animal injury models, C-OD2"s hemostasis time and blood loss were fairly lower than commercial gelatin sponge.	Water	360-365	COD2	Homo sapiens	255-260
34856346-6	2022	Both AQP3- and AQP15- microinjected oocytes exhibited significantly elevated apparent water permeability compared to control oocytes at neutral pH.	Water	86-91	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	5-9
34856346-7	2022	The apparent water permeability was mercury-inhibitable, significantly so in the case of AQP3.	Water	13-18	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	89-93
34856346-8	2022	AQP3 microinjected oocytes showed pH sensitivity in their apparent water permeability, showing a lack of permeability at acidic pH values.	Water	67-72	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	0-4
34856346-20	2022	The localization of AQP3 and AQP15 in the spiral valve intestine suggests that a trans-cellular water absorption pathway may exist in this tissue.	Water	96-101	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	20-24
28725129-3	2017	RESULTS: The mean fluoride content of tap water samples was 0.14 mg F/L with a range of 0.04-0.3 mg F/L; with Ajman tap water samples showing the highest mean fluoride content of 0.3 mg F/L.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
34510342-0	2022	Microscale Toxicity Identification Evaluation (TIE) for interstitial water of estuarine sediments affected by multiple sources of pollution.	Water	69-74	tyrosine kinase with immunoglobulin like and EGF like domains 1	Homo sapiens	47-50
28725129-6	2017	CONCLUSIONS: The tap water, bottled water and beverages available in U.A.E show varying concentrations of fluoride, however none showed the optimal level necessary to prevent dental caries.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
28723118-8	2017	Because of ultrahigh sensitivity and excellent selectivity, the proposed system can be employed for assaying ultratrace of Hg2+ containing in drinking and commonly environmental water samples, which is difficult to be achieved by conventional colorimetric systems.	Water	178-183	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	123-126
34510342-4	2022	The aim of this study is to evaluate the diagnosis provided by a TIE based on microscale embryotoxicity tests with interstitial water (IW) to identify toxicants in estuarine sediments affected by multiple stressors.	Water	128-133	tyrosine kinase with immunoglobulin like and EGF like domains 1	Homo sapiens	65-68
27829559-9	2017	Furthermore, the biosensor excels in the practical application in water samples (e.g., lake, tap and drinking water) owing to its non-interference and on-site rapid determination.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	93-96
34399176-4	2022	The addition of alpha-amylase and lipase could decrease the retrogradation enthalpy and bound water, and increase the mobility of mobile water.	Water	94-99	alpha-amylase	Solanum tuberosum	16-29
34399176-4	2022	The addition of alpha-amylase and lipase could decrease the retrogradation enthalpy and bound water, and increase the mobility of mobile water.	Water	94-99	lipase	Solanum tuberosum	34-40
34399176-4	2022	The addition of alpha-amylase and lipase could decrease the retrogradation enthalpy and bound water, and increase the mobility of mobile water.	Water	137-142	alpha-amylase	Solanum tuberosum	16-29
34399176-4	2022	The addition of alpha-amylase and lipase could decrease the retrogradation enthalpy and bound water, and increase the mobility of mobile water.	Water	137-142	lipase	Solanum tuberosum	34-40
28649202-9	2017	Upon its activation aqp-8 promotes vesicle docking to the lumen of the excretory cell and thereby enhances the ability to secrete water and transport osmotic active substances or waste products caused by protein damage.	Water	130-135	AQuaPorin or aquaglyceroporin related	Caenorhabditis elegans	20-25
34818775-3	2022	OBJECTIVES: We aimed to: 1) measure VOCs in residential indoor air and tap water from EXPERIVA participants; 2) compare concentrations with those in the general population and explore differences related to sociodemographic and housing characteristics; and 3) determine associations between VOC concentrations and density/proximity to UNG wells.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
34818775-7	2022	We assessed the association between different metrics of well density/proximity and indoor air and tap water VOC concentrations using multiple linear regression.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
34818775-10	2022	Indoor air levels of chloroform and tap water levels of total trihalomethanes were higher in Indigenous participants compared to non-Indigenous participants.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
28524666-0	2017	Possible Formation of H3O+ Cations Due to Aluminum Fluoride Interactions with Water.	Water	78-83	H3 clustered histone 15	Homo sapiens	22-25
34818775-11	2022	Indoor air levels of chloroform and acetone, and tap water levels of total trihalomethanes were positively associated with UNG wells density/proximity metrics.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
28524666-2	2017	The calculations performed for the AlF3 n(H2O) systems (n = 1-6) revealed that facial and meridional octahedral structures correspond to the lowest energy isomers for the AlF3 4H2O, AlF3 5H2O, and AlF3 6H2O systems, whereas the isomers containing the H3O+ and AlF3OH- fragments were predicted to be less stable by only 5-7 kcal/mol, which indicates the possible formation of the hydronium cations in such systems even at room temperature.	Water	42-45	H3 clustered histone 15	Homo sapiens	251-254
34428683-3	2022	NiFe-coated Co(OH)2 nanosheet array (NiFe@Co(OH)2 NSAs/NF) was further constructed by electrodeposition for water splitting.	Water	108-113	neurofascin	Homo sapiens	55-57
34428683-5	2022	Thanks to the excellent 3D nanosheet array structure and the close integration between Co(OH)2 and the upper layer NiFe, NiFe@Co(OH)2 NSAs/NF with a deposition time of 200 s (NiFe-200@Co(OH)2 NSAs/NF) can provide 10 mA cm-2 with only 204 mV and maintain constant catalysis within 100 h. Therefore, the constructed NiFe@Co(OH)2 NSAs/NF (500  200) double-electrode cell for water splitting requires only 1.58 V drive potential and can maintain 24 h durability at 10 mA cm-2.	Water	372-377	neurofascin	Homo sapiens	139-141
28287650-4	2017	The powdered Z-scheme system produced CO from CO2 in addition to H2 and O2 due to water splitting.	Water	82-87	relaxin 2	Homo sapiens	65-74
34428683-5	2022	Thanks to the excellent 3D nanosheet array structure and the close integration between Co(OH)2 and the upper layer NiFe, NiFe@Co(OH)2 NSAs/NF with a deposition time of 200 s (NiFe-200@Co(OH)2 NSAs/NF) can provide 10 mA cm-2 with only 204 mV and maintain constant catalysis within 100 h. Therefore, the constructed NiFe@Co(OH)2 NSAs/NF (500  200) double-electrode cell for water splitting requires only 1.58 V drive potential and can maintain 24 h durability at 10 mA cm-2.	Water	372-377	neurofascin	Homo sapiens	197-199
34428683-5	2022	Thanks to the excellent 3D nanosheet array structure and the close integration between Co(OH)2 and the upper layer NiFe, NiFe@Co(OH)2 NSAs/NF with a deposition time of 200 s (NiFe-200@Co(OH)2 NSAs/NF) can provide 10 mA cm-2 with only 204 mV and maintain constant catalysis within 100 h. Therefore, the constructed NiFe@Co(OH)2 NSAs/NF (500  200) double-electrode cell for water splitting requires only 1.58 V drive potential and can maintain 24 h durability at 10 mA cm-2.	Water	372-377	neurofascin	Homo sapiens	332-334
28279766-1	2017	The water soluble protein-sulfated fucan (PSF) complex isolated from the body wall of Stichopus japonicus was fractionated using an anion-exchange chromatography to obtain four purified fractions (F1, F2, F3, and F4) and to investigate their structural characteristics and immuno-enhancing activities.	Water	4-9	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	Mus musculus	42-45
34896860-4	2022	Herein, a biocompatible carbon nitride (C3N4)/nanozyme/GOx triple cascade nanocatalyst was designed with laser-activatable O2 self-supply via water splitting to relieve tumor hypoxia and thus improve the catalysis efficiency.	Water	142-147	hydroxyacid oxidase 1	Homo sapiens	55-58
28366356-10	2017	Median PRP on CPAP of 5 cm H2O prior to extubation 255 (176, 375) was significantly lower than all postextubation values (P?&lt;?.002).	Water	27-30	centromere protein J	Homo sapiens	14-18
34303907-5	2022	In this study, four simple and easy water quality parameters (temperature, pH, UVA254 and Cl2) were used to predict trihalomethane (THMs) occurrence in tap water.	Water	36-41	endogenous retrovirus group W member 5	Homo sapiens	90-93
34303907-5	2022	In this study, four simple and easy water quality parameters (temperature, pH, UVA254 and Cl2) were used to predict trihalomethane (THMs) occurrence in tap water.	Water	156-161	endogenous retrovirus group W member 5	Homo sapiens	90-93
34952077-1	2022	The UV/Cl2 process (also known as chlorine photolysis, which is the combination of chlorine and simultaneous irradiation of UV light) is conventionally applied at acidic mediums for drinking water treatment and further treatment of wastewater effluents for secondary reuse.	Water	191-196	endogenous retrovirus group W member 5	Homo sapiens	7-10
28598349-4	2017	Respondents with lower levels of environmental concern, education levels, and lower organoleptic perceptions were most likely to perceive health risks from tap water consumption, and were most likely to use bottled water.	Water	160-165	nuclear RNA export factor 1	Homo sapiens	156-159
34717945-8	2022	The introduction of HNP at a higher water bath temperature helped increase the water flux up to ten times, moreover, the oil-water separation efficiency could still reach over 99.50%.	Water	36-41	kallikrein related peptidase 8	Homo sapiens	20-23
34717945-8	2022	The introduction of HNP at a higher water bath temperature helped increase the water flux up to ten times, moreover, the oil-water separation efficiency could still reach over 99.50%.	Water	79-84	kallikrein related peptidase 8	Homo sapiens	20-23
34717945-8	2022	The introduction of HNP at a higher water bath temperature helped increase the water flux up to ten times, moreover, the oil-water separation efficiency could still reach over 99.50%.	Water	125-130	kallikrein related peptidase 8	Homo sapiens	20-23
34370193-11	2022	This study enriches environmental monitoring data of pharmaceuticals in drinking water sources and tap water, and provides scientific information for emerging pollutants management in drinking water system.	Water	193-198	nuclear RNA export factor 1	Homo sapiens	99-102
34396474-1	2022	Approximately 99.1% of South Koreans have access to drinkable tap water from river basins.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
34396474-2	2022	Due to such a high access rate, the South Korean government has been running, since 2013, a long-term program for monitoring the quality of tap water for drinking.	Water	144-149	nuclear RNA export factor 1	Homo sapiens	140-143
34396474-10	2022	Considering the potency of N-nitrosamines in tap water for drinking, the levels of these substances in the finished water of DWTPs in South Korea should be continuously monitored.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
34689089-6	2022	For instance, the adsorption efficiency of Cr3+ and Cr6+ is found to be 42.02% and 5.79% respectively using microcellulose, while nanocellulose adsorbed 62.40% of Cr3+ ions and 5.98% of Cr6+ ions from contaminated water.	Water	214-219	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	52-55
27342260-8	2017	CONCLUSION: For the sequences and models considered in this study, transcytolemmal water exchange has minor effects on the fittings of d and Din with physiologically relevant membrane permeabilities if the SNR is sufficient (&gt; 50), but fin is intrinsically underestimated.	Water	83-88	RIKEN cDNA 4930453N24 gene	Mus musculus	141-144
34689089-6	2022	For instance, the adsorption efficiency of Cr3+ and Cr6+ is found to be 42.02% and 5.79% respectively using microcellulose, while nanocellulose adsorbed 62.40% of Cr3+ ions and 5.98% of Cr6+ ions from contaminated water.	Water	214-219	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	186-189
34749143-5	2022	We compared the cleaning efficiency of TAP water, two grades of purified water, NaCl solution and SDS solution.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
34749143-6	2022	FINDINGS: The QCM-D results show that both grades of purified water remove more than 90% of Vaseline deposited of the surface while tap water only 75%.	Water	136-141	nuclear RNA export factor 1	Homo sapiens	132-135
34467478-7	2022	Bentazone was frequently detected (detection frequency: 96.3%) in 160 tap water samples (underwent conventional treatment) (median: 1.95 ng/L, range: <0.02-47.0 ng/L), while it was not detectable in tap water samples that underwent ozone combined with activated carbon.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
34467478-10	2022	The estimated daily intake of bentazone based on its median concentration in tap water (0.04 ng/kg-body weight (bw)/day) accounted for approximately 8% of that based on the median urinary concentration (0.48 ng/kg-bw/day).	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
28713508-9	2017	CONCLUSION: Our drinking tap water samples include a large quantity of THMs with different concentrations, where the dibromochloromethane and the bromoform constitute the major portion of THMs.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
34627965-0	2022	Seasonal distribution of antibiotic resistance genes in the Yellow River water and tap water, and their potential transmission from water to human.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
34627965-0	2022	Seasonal distribution of antibiotic resistance genes in the Yellow River water and tap water, and their potential transmission from water to human.	Water	132-137	nuclear RNA export factor 1	Homo sapiens	83-86
34627965-3	2022	Here, we employed 16S rRNA gene sequencing and high-throughput quantitative PCR techniques to explore the seasonal distribution of ARGs and opportunistic pathogens in the Yellow River water (source water) and tap water, as well as their relationships with healthy humans at Lanzhou, China.	Water	213-218	nuclear RNA export factor 1	Homo sapiens	209-212
34627965-5	2022	The absolute abundance and diversity of ARGs in the Yellow River and tap water demonstrated distinct seasonal patterns.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
34890582-1	2022	Aquaporin 4 (AQP4) is a water transporting, transmembrane channel protein that has important regulatory roles in maintaining cellular water homeostasis.	Water	24-29	aquaporin 4	Homo sapiens	0-11
34890582-1	2022	Aquaporin 4 (AQP4) is a water transporting, transmembrane channel protein that has important regulatory roles in maintaining cellular water homeostasis.	Water	24-29	aquaporin 4	Homo sapiens	13-17
34890582-1	2022	Aquaporin 4 (AQP4) is a water transporting, transmembrane channel protein that has important regulatory roles in maintaining cellular water homeostasis.	Water	134-139	aquaporin 4	Homo sapiens	0-11
34890582-1	2022	Aquaporin 4 (AQP4) is a water transporting, transmembrane channel protein that has important regulatory roles in maintaining cellular water homeostasis.	Water	134-139	aquaporin 4	Homo sapiens	13-17
28348157-8	2017	However, hydrophobic patches near the PER-2 active site (by Ser70 and B3-B4 beta-strands) were observed and may affect the binding of necessary catalytic water molecules, thus slowing acylation (k2/K) of AVI onto PER-2.	Water	154-159	period circadian regulator 2	Homo sapiens	38-43
34741586-5	2022	In the present study, we exposed 4-week-old male C57BL/6 mice to 3 mg/L Cd via drinking water for 28 weeks and assessed their hippocampus-dependent learning and memory.	Water	88-93	cathepsin D	Mus musculus	72-74
34627965-6	2022	In winter, the Yellow river water had the highest ARG abundance and diversity, while tap water owned the lowest.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
34627965-7	2022	Mobile genetic elements (MGEs) were the predominant driver of ARG profiles in both the Yellow river and tap water.	Water	108-113	nuclear RNA export factor 1	Homo sapiens	104-107
34627965-8	2022	Null model analysis showed that ARG assembly in the Yellow River was more influenced by stochastic processes than tap water and this was independent of seasons.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
28511329-2	2017	Methods: The FGF1-loaded nano-liposomes were prepared by water-in-water emulsion method combined with lyophilization technique.TypeIdiabetes model was induced by intraperitoneal injection of streptozotocin (STZ, 70 mg/kg) in 60 male SD rats.Sixteen weeks later, diabetic rats were randomly divided into: placebo group (saline treatment), FGF1 group, FGF1-loaded nano-liposomes group, and FGF1-loaded nano-liposomes plus UTMD group (n=15 each).	Water	57-62	fibroblast growth factor 1	Rattus norvegicus	13-17
34627965-13	2022	Thus, it is crucial to protect sources of tap water from anthropogenic pollution and improve water treatment technologies to reduce the dissemination of ARGs and ensure drinking-water biosafety for human health.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
34653511-5	2022	The inhibition of pgrmc1 exacerbated the neonatal brain damage in the acute stage of HI in male mice as seen in the increase in brain water content, infarction area, and neuronal death.	Water	134-139	progesterone receptor membrane component 1	Mus musculus	18-24
34759078-7	2022	Changes in the pH by mouth rinsing with AEW and purified tap water (PTW) were analyzed.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
28511329-2	2017	Methods: The FGF1-loaded nano-liposomes were prepared by water-in-water emulsion method combined with lyophilization technique.TypeIdiabetes model was induced by intraperitoneal injection of streptozotocin (STZ, 70 mg/kg) in 60 male SD rats.Sixteen weeks later, diabetic rats were randomly divided into: placebo group (saline treatment), FGF1 group, FGF1-loaded nano-liposomes group, and FGF1-loaded nano-liposomes plus UTMD group (n=15 each).	Water	66-71	fibroblast growth factor 1	Rattus norvegicus	13-17
34384964-5	2022	This binder-free catalyst for overall water splitting, i.e., Co/NCNTs-NF-900, has excellent catalytic activity and durability.	Water	38-43	neurofascin	Homo sapiens	70-72
28588500-4	2017	Anoctamin 1 (ANO1, also known as TMEM16A) and Aquaporin 5 (AQP5) play an important role in the transport of ions and water in the submandibular glands (SGs).	Water	117-122	aquaporin 5	Rattus norvegicus	46-57
34525701-6	2022	By combining water chemistry data from public reports, socioeconomic information from the US census, and spatial features using Geographic Information Systems, we trained and tested models to estimate the likelihood of lead contaminated tap water in over 8,000 schools across California and Massachusetts.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	237-240
34525701-6	2022	By combining water chemistry data from public reports, socioeconomic information from the US census, and spatial features using Geographic Information Systems, we trained and tested models to estimate the likelihood of lead contaminated tap water in over 8,000 schools across California and Massachusetts.	Water	241-246	nuclear RNA export factor 1	Homo sapiens	237-240
34851473-8	2022	The method has been applied to honey and tap water samples and the recoveries were found to be in the range of 91.3 and 101.1 %.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
28588500-4	2017	Anoctamin 1 (ANO1, also known as TMEM16A) and Aquaporin 5 (AQP5) play an important role in the transport of ions and water in the submandibular glands (SGs).	Water	117-122	aquaporin 5	Rattus norvegicus	59-63
28447461-2	2017	VT-MIR spectra demonstrate that recrystallization temperatures of water sorbed into the polymers are positively correlated with their glass-transition temperatures reported previously.	Water	66-71	membrane associated ring-CH-type finger 8	Homo sapiens	3-6
34837761-2	2022	Glycyrrhiza Polysaccharides (GPS-1) are water-soluble neutral polysaccharides extracted from licorice.	Water	40-45	G protein pathway suppressor 1	Gallus gallus	29-34
34894436-0	2022	Porous electrospun microfibers for low flow-resistant solid phase extraction of fluoroquinolones in tap water, egg and milk samples.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
28407339-5	2017	Photocatalytic overall water splitting proceeded using MoOx /Pt/SrTiO3 with inhibited water formation from H2 and O2 , which is the prevailing back reaction on the bare Pt/SrTiO3 photocatalyst.	Water	23-28	relaxin 2	Homo sapiens	107-116
34894436-6	2022	Using the PEMF-SPE cartridges with ultra-performance liquid chromatography-fluorescence detector (UPLC-FLD), five fluoroquinolones (FQs) in tap water, egg and milk samples were extracted and quantified successfully.	Water	144-149	nuclear RNA export factor 1	Homo sapiens	140-143
34894436-10	2022	The reliability of the developed method was validated by analyzing tap water, egg and milk samples, and the recovery values were found to be in the range of 74.8-116.6% under the optimized conditions.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
34852210-3	2022	PON2 and PON3 are expressed in the aldosterone-sensitive distal nephron of the kidney and have been shown to negatively regulate expression of the epithelial sodium channel (ENaC), a trimeric ion channel that orchestrates salt and water homeostasis.	Water	231-236	paraoxonase 2	Homo sapiens	0-4
34852210-3	2022	PON2 and PON3 are expressed in the aldosterone-sensitive distal nephron of the kidney and have been shown to negatively regulate expression of the epithelial sodium channel (ENaC), a trimeric ion channel that orchestrates salt and water homeostasis.	Water	231-236	paraoxonase 3	Homo sapiens	9-13
34961483-14	2021	Sembule village had a token-operated water tap, which had broken down 1 month before the outbreak, forcing residents to obtain water from one of three wells (Wells A, B, C) or a public tap.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	43-46
34961483-14	2021	Sembule village had a token-operated water tap, which had broken down 1 month before the outbreak, forcing residents to obtain water from one of three wells (Wells A, B, C) or a public tap.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	185-188
34961483-14	2021	Sembule village had a token-operated water tap, which had broken down 1 month before the outbreak, forcing residents to obtain water from one of three wells (Wells A, B, C) or a public tap.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	43-46
34961483-16	2021	Drinking water from a public tap (ORM-H = 0.07, 95% CI 0.014-0.304) was protective.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	29-32
34839790-2	2021	Synthetic stormwater was created by adding metal salts, oil and collected stormwater sediment to tap water.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
34670777-12	2022	BOPTA transport by Mrp2 induced an aquaporin-mediated water transport, while MEB transport did not.	Water	54-59	ATP binding cassette subfamily C member 2	Rattus norvegicus	19-23
28407339-5	2017	Photocatalytic overall water splitting proceeded using MoOx /Pt/SrTiO3 with inhibited water formation from H2 and O2 , which is the prevailing back reaction on the bare Pt/SrTiO3 photocatalyst.	Water	86-91	relaxin 2	Homo sapiens	107-116
28276891-2	2017	The tap water was used as scrubbing liquid.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
28467818-6	2017	Here we develop surrogate Wnt agonists, water-soluble FZD-LRP5/LRP6 heterodimerizers, with FZD5/FZD8-specific and broadly FZD-reactive binding domains.	Water	40-45	LDL receptor related protein 6	Homo sapiens	63-67
34971785-1	2022	Elastin-like polymers (ELPs) and their chimeric subfamily the silk elastin-like polymers (SELPs) exhibit a lower critical solvation temperature (LCST) behavior in water which has been extensively studied from theoretical, computational and experimental perspectives.	Water	163-168	elastin	Homo sapiens	0-7
34971785-1	2022	Elastin-like polymers (ELPs) and their chimeric subfamily the silk elastin-like polymers (SELPs) exhibit a lower critical solvation temperature (LCST) behavior in water which has been extensively studied from theoretical, computational and experimental perspectives.	Water	163-168	elastin	Homo sapiens	67-74
34961995-4	2022	In order to decipher relaxation changes, three main invasion/migration pathophysiological processes were studied: hypoxia, H2 O2 function and the water-channel aquaporin-4 (AQP4).	Water	146-151	aquaporin 4	Mus musculus	173-177
34923994-2	2021	BACKGROUND: Aquagenic pruritus (AP), an intense sensation of scratching induced after water contact, is the most troublesome aspect of BCR-ABL1-negative myeloproliferative neoplasms (MPNs).	Water	86-91	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	139-143
34922349-6	2021	Moreover, ZmPMTR1 largely rescued defect of melatonin-induced stomatal closure in the cand2-1 mutant, thereby reducing water loss rate and increasing drought stress tolerance.	Water	119-124	Protein of unknown function, transmembrane-40	Arabidopsis thaliana	86-91
34961995-9	2022	At very low-field the role of water-exchanges in relaxation modulation was confirmed and for the first time it was linked to the glioma invasion/migration and to its main pathophysiological processes: hypoxia, H2 O2 redox-signaling and AQP4-expression.	Water	30-35	aquaporin 4	Mus musculus	236-240
28490769-6	2017	Heat stroke cases showed an increase in brain water content, which was found to be positively correlated with MMP9, OCLN, ZO1 and CLDN5 mRNA.	Water	46-51	matrix metallopeptidase 9	Homo sapiens	110-114
34936709-2	2022	P-aminophenol (PAP), the main hydrolytic degradation product of PAC, can be found in environmental water.	Water	99-104	poly(A) polymerase alpha	Homo sapiens	15-18
34948308-2	2021	Because AQP5 is not regulated by gating, localization on the plasma membrane is important for its water-permeable function.	Water	98-103	aquaporin 5	Mus musculus	8-12
29926597-4	2017	In vivo experiment, similarly to Orlistat, water extract of lotus leaves(60 mg/kg)markedly decreased the body weight and blood lipid of experimental obesity rats(P&lt;0.05), and obviously reduced the expressions of PPAR-gamma and leptin(P&lt;0.05).	Water	43-48	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	215-225
34688701-0	2021	Inferred inactivation of the CFTR gene in the duodena of mice exposed to hexavalent chromium (Cr(VI)) in drinking water supports its tumor-suppressor status and implies its potential role in Cr(VI)-induced carcinogenesis of the small intestines.	Water	114-119	cystic fibrosis transmembrane conductance regulator	Mus musculus	29-33
34961219-5	2021	Compared with the water control treatment, the combined ABA + CaCl2 treatment significantly improved the superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) of the seedlings by 34.47%, 59.66%, and 118.80%, respectively (p < 0.05), and significantly reduced the chilling injury index, relative electrical conductivity, and MDA content, by 89.47%, 62.17%, and 44.55%, respectively (p < 0.05).	Water	18-23	catalase isozyme 1	Cucumis sativus	133-141
34939374-6	2022	In the two-electrode overall water splitting system with Ag500-MoS2 @Ni3 S2 /NF, a small cell voltage of 1.47 V yields 10 mA cm-2 and very little degradation is observed after operation for 70 hours.	Water	29-34	neurofascin	Homo sapiens	77-79
34961219-5	2021	Compared with the water control treatment, the combined ABA + CaCl2 treatment significantly improved the superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) of the seedlings by 34.47%, 59.66%, and 118.80%, respectively (p < 0.05), and significantly reduced the chilling injury index, relative electrical conductivity, and MDA content, by 89.47%, 62.17%, and 44.55%, respectively (p < 0.05).	Water	18-23	catalase isozyme 1	Cucumis sativus	143-146
34949441-0	2022	Work site access to fluoridated tap water and retail beverages: An assessment of the University of California, San Francisco campuses.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
29926597-5	2017	CONCLUSIONS: Water extract of lotus leaves greatly improves the expression of PPAR-gamma and leptin, which can promote the lipid mobilization and dissolution, reduce the body weight and blood lipid of adult rats with experimental obesity, therefore is expected to be developed into lipid-lowering diet pills.	Water	13-18	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	78-88
34949441-2	2022	The purpose of this study was to assess the availability, appeal, and promotion of fluoridated tap water in publicly accessible spaces compared with retail beverages at the University of California, San Francisco.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
34940265-5	2021	The air-bridge capacitor in the modeled RLC circuit serves as a bio-recognition element to glucose concentration (epsilonglucoseC0), generating resonant frequency shifts at 0.874 GHz and 1.244 GHz for concentrations of 25 mg/dL and 300 mg/dL compared to DI water, respectively.	Water	257-262	integrin subunit alpha 9	Homo sapiens	40-43
27279485-0	2017	Secretin, at the hub of water-salt homeostasis.	Water	24-29	secretin	Homo sapiens	0-8
34467936-8	2021	The health risk assessment implied that estimated daily intake of these fungicides through tap water ingestion might pose a low risk to consumers, though risk associated with infant exposure to the fungicides requires further attention.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
34467936-9	2021	This study provides baseline data on the occurrence, removal efficiencies, and seasonal variations of the selected fungicides in tap water from central China.	Water	133-138	nuclear RNA export factor 1	Homo sapiens	129-132
34928963-6	2021	Water stress enhanced peroxidase (POD), catalase (CAT), superoxide dismutase (SOD), polyphenol oxidase (PPO), soluble sugar, malondialdehyde (MDA), proline contents as well as leaf temperature while substantially reduced leaf water contents (21%), stomatal conductance (50%), chlorophyll contents (10-67%), membrane stability index (24%) and grain yield (30%) of canola.	Water	0-5	catalase-3-like	Brassica napus	40-48
34928963-6	2021	Water stress enhanced peroxidase (POD), catalase (CAT), superoxide dismutase (SOD), polyphenol oxidase (PPO), soluble sugar, malondialdehyde (MDA), proline contents as well as leaf temperature while substantially reduced leaf water contents (21%), stomatal conductance (50%), chlorophyll contents (10-67%), membrane stability index (24%) and grain yield (30%) of canola.	Water	0-5	catalase-3-like	Brassica napus	50-53
27279485-4	2017	Some of the better-characterized regulators of water and salt homeostasis include angiotensin II, aldosterone, arginine vasopressin, and oxytocin.	Water	47-52	oxytocin/neurophysin I prepropeptide	Homo sapiens	137-145
34846884-0	2021	Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket.	Water	10-15	BCL6 transcription repressor	Homo sapiens	28-32
34846884-1	2021	We describe the optimization of modestly active starting points to potent inhibitors of BCL6 by growing into a subpocket, which was occupied by a network of five stably bound water molecules.	Water	175-180	BCL6 transcription repressor	Homo sapiens	88-92
28323996-2	2017	The use of zebrafish as a model system revealed that FGF23 is specifically expressed in the corpuscles of Stannius (CS), an organ involved in Ca2+ homeostasis in fish, and that its expression is stimulated by ambient water with a high Ca2+ level.	Water	217-222	fibroblast growth factor 23	Danio rerio	53-58
34534832-8	2021	Although the estimated daily intake of NEOs were much lower than the reference dose, the potential health risk of NEOs via tap water consumption should raise more public concern considering the high detection rates of NEOs in tap water.	Water	230-235	nuclear RNA export factor 1	Homo sapiens	123-126
34534832-8	2021	Although the estimated daily intake of NEOs were much lower than the reference dose, the potential health risk of NEOs via tap water consumption should raise more public concern considering the high detection rates of NEOs in tap water.	Water	230-235	nuclear RNA export factor 1	Homo sapiens	226-229
34882725-4	2021	The simulated data from January to September 2017 showed that FRWs can change the vertical temperature distribution during the stratification period, accelerate the upper warmer water release and thus decrease the strength of thermal stratification.	Water	178-183	cytokine receptor like factor 3	Homo sapiens	62-66
34882725-9	2021	In addition, FRWs can continuously obtain surface warmer water without manual operation and have low investment and good construction conditions.	Water	57-62	cytokine receptor like factor 3	Homo sapiens	13-17
28441356-1	2017	This research has developed a simple to use, cost effective sensor system for the detection of lead ions in tap water.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
34976726-9	2022	With the integration time of 1 s, the detection limits for H2O, C2H2 and CO2 are 1.2 ppm, 28.8 ppb and 2.4 ppm, respectively.	Water	59-62	histatin 1	Homo sapiens	95-98
34976726-10	2022	The detection limits for H2O, C2H2 and CO2 can be further improved to 325 ppb, 10.3 ppb and 318 ppb by increasing the integration time to 521 s, 183 s and 116 s.	Water	25-28	histatin 1	Homo sapiens	74-77
34715591-2	2021	The autoantibody is generated against the abundant water channel protein of the brain, Aquaporin 4 (AQP4).	Water	51-56	aquaporin 4	Homo sapiens	87-98
34715591-2	2021	The autoantibody is generated against the abundant water channel protein of the brain, Aquaporin 4 (AQP4).	Water	51-56	aquaporin 4	Homo sapiens	100-104
28441356-4	2017	Tap water from the Cleveland, OH, USA regional water district was the test medium.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
34976726-10	2022	The detection limits for H2O, C2H2 and CO2 can be further improved to 325 ppb, 10.3 ppb and 318 ppb by increasing the integration time to 521 s, 183 s and 116 s.	Water	25-28	histatin 1	Homo sapiens	84-87
34976726-10	2022	The detection limits for H2O, C2H2 and CO2 can be further improved to 325 ppb, 10.3 ppb and 318 ppb by increasing the integration time to 521 s, 183 s and 116 s.	Water	25-28	histatin 1	Homo sapiens	96-99
34190981-5	2021	Results of water analysis indicated that fluoride content in tap water ranged from 0.267 to 0.336 mg/L (average 0.304 mg/L), and the levels of fluoride in purified water and bottled water were 0.068-0.317 mg/L (average 0.134 mg/L) and 0-0.120 mg/L (average 0.080 mg/L), respectively.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
28441356-6	2017	The calibration curve for the DPV measurements of lead ions in tap water showed excellent reproducibility with R2 value of 0.970.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
34190981-7	2021	The low fluoride exposure for the population in the studied area was observed, and the replacement of tap water with purified and bottled water could further aggravate the deficient of fluoride intake for local residents.	Water	106-111	nuclear RNA export factor 1	Homo sapiens	102-105
28433034-1	2017	At ambient temperature, conversion from 100% enriched para-hydrogen (p-H2; singlet state) to ortho-hydrogen (o-H2; triplet state) leads necessarily to the thermodynamic equilibrium proportions: 75% of o-H2 and 25% of p-H2.	Water	109-113	polyhomeotic homolog 2	Homo sapiens	217-221
34963957-5	2021	The synthesized CNF filters show excellent performance and successful removal of contaminants from the water by analyzing the CNF-based filters before and after the filtration of water through SEM and energy-dispersive X-ray (EDX) spectroscopy.	Water	103-108	NPHS1 adhesion molecule, nephrin	Homo sapiens	16-19
34963957-5	2021	The synthesized CNF filters show excellent performance and successful removal of contaminants from the water by analyzing the CNF-based filters before and after the filtration of water through SEM and energy-dispersive X-ray (EDX) spectroscopy.	Water	179-184	NPHS1 adhesion molecule, nephrin	Homo sapiens	16-19
34560931-1	2021	A kind of starch-based flocculant (starch-graft-poly((2-methacryloyloxyethyl) trimethyl ammonium chloride), denoted St-g-PDMC-LPUV) has been synthesized by low-pressure ultraviolet initiation and was employed to remove humic acid (HA) for water purification.	Water	239-244	chromosome 6 open reading frame 15	Homo sapiens	116-120
34425373-1	2021	This review is intended to evaluate the use of ferrate (Fe(VI)), being a green coagulant, sustainable and reactive oxidant, to remove micro pollutants especially pharmaceutical pollutants in contaminated water.	Water	204-209	general transcription factor IIE subunit 1	Homo sapiens	56-62
28433034-1	2017	At ambient temperature, conversion from 100% enriched para-hydrogen (p-H2; singlet state) to ortho-hydrogen (o-H2; triplet state) leads necessarily to the thermodynamic equilibrium proportions: 75% of o-H2 and 25% of p-H2.	Water	201-205	polyhomeotic homolog 2	Homo sapiens	69-73
28433034-1	2017	At ambient temperature, conversion from 100% enriched para-hydrogen (p-H2; singlet state) to ortho-hydrogen (o-H2; triplet state) leads necessarily to the thermodynamic equilibrium proportions: 75% of o-H2 and 25% of p-H2.	Water	201-205	polyhomeotic homolog 2	Homo sapiens	217-221
28433034-5	2017	Also, as the para ortho conversion is monitored by proton nuclear magnetic resonance (NMR) of dissolved o-H2 (p-H2 is NMR-silent), one has to account for H2 exchange between the liquid phase and the gas phase within the NMR tube, as well as for dissolution effects.	Water	104-108	polyhomeotic homolog 2	Homo sapiens	110-114
28473751-5	2017	Also, the nuclear expression of c-Fos, a marker for neuronal activation, related to water-consumption (SFO and MnPO) was inhibited.	Water	84-89	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-37
34880650-2	2021	While there are nine isoforms of NHE in humans, this review focuses on the NHE3 isoform, which is abundantly expressed in the gastrointestinal tract, where it plays a key role in acid-base balance and water homeostasis.	Water	201-206	solute carrier family 9 member A3	Homo sapiens	75-79
34880650-3	2021	NHE3 inhibition in the small intestine results in luminal sodium and water retention, leading to a general decrease in paracellular water flux and diffusional driving force, reduced intestinal sodium absorption, and increased stool sodium excretion.	Water	69-74	solute carrier family 9 member A3	Homo sapiens	0-4
28373562-5	2017	When the pressure is increased from 10 to 600 MPa along the 280-K isotherm, we observe that water inside the 1.25-nm-diameter CNT can undergo low-density liquid to hINT to high-density liquid reentrant first-order transitions.	Water	92-97	inturned planar cell polarity protein	Homo sapiens	164-168
34880650-3	2021	NHE3 inhibition in the small intestine results in luminal sodium and water retention, leading to a general decrease in paracellular water flux and diffusional driving force, reduced intestinal sodium absorption, and increased stool sodium excretion.	Water	132-137	solute carrier family 9 member A3	Homo sapiens	0-4
28420179-1	2017	Salvianolic acid A (SAA) is one of the most abundant water-soluble and potent anti-oxidative compounds isolated from Danshen, a traditional Chinese medicine.	Water	53-58	serum amyloid A1 cluster	Homo sapiens	20-23
27825522-6	2017	The aptasensor was also used to detect Hg2+ from real water samples, and the results showed excellent agreement with the values determined by atomic fluorescence spectrometer.	Water	54-59	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	39-42
28129907-5	2017	The accumulation of EOX in the soil appears to play a significant role in subsequent bioaccumulation in cultures irrigated with tap water (long term memory effect).	Water	132-137	nuclear RNA export factor 1	Homo sapiens	128-131
28384265-8	2017	Since CFTR has been suggested to play a role in water and nutrient exchange in the placenta through its interaction with aquaporins, we analyzed placental aquaporin expression in late-gestation CF and control littermates.	Water	48-53	cystic fibrosis transmembrane conductance regulator	Mus musculus	6-10
28368045-1	2017	Cellulose nanofibril/graphene oxide hybrid (CNF/GO) aerogel was fabricated via a one-step ultrasonication method for adsorptive removal of 21 kinds of antibiotics in water.	Water	166-171	NPHS1 adhesion molecule, nephrin	Homo sapiens	44-47
28412830-3	2017	METHODS: Escherichia coli expression system was used to express VP40 protein of Zaire Ebola virus (ZEBOV) as water-soluble protein upon optimization of temperature, time, and IPTG concentration.	Water	109-114	matrix protein	Zaire ebolavirus	64-68
28412830-6	2017	RESULTS: Recombinant full-length VP40 protein of ZEBOV was expressed in E. coli Rosetta (DE3) cells as water-soluble protein.	Water	103-108	matrix protein	Zaire ebolavirus	33-37
27317656-4	2017	Endogenous low-density lipoprotein receptor-related protein-1 and hemopexin were increased in ipsilateral brain after intracerebral hemorrhage, accompanied by increased hemoglobin levels, brain water content, blood-brain barrier permeability and neurological deficits.	Water	194-199	low density lipoprotein receptor-related protein 1	Mus musculus	11-61
28154204-3	2017	Molecular species desorbed as the [M + H]+ ions were subjected to LIT MS2 to yield predominately the [M + H - H2O]+ ions, followed by MS3 to cleave the 1-O-acyl residue to yield the [M + H - H2O - (1-O-FA)]+ ions.	Water	110-113	minisatellites detected by probe MMS2	Mus musculus	70-73
28154204-3	2017	Molecular species desorbed as the [M + H]+ ions were subjected to LIT MS2 to yield predominately the [M + H - H2O]+ ions, followed by MS3 to cleave the 1-O-acyl residue to yield the [M + H - H2O - (1-O-FA)]+ ions.	Water	191-194	minisatellites detected by probe MMS2	Mus musculus	70-73
28488242-1	2017	Aquaporin-4 (AQP4) is a selective water channel mediating water transport across cell membranes in skeletal muscles.	Water	34-39	aquaporin 4	Homo sapiens	0-11
28488242-1	2017	Aquaporin-4 (AQP4) is a selective water channel mediating water transport across cell membranes in skeletal muscles.	Water	34-39	aquaporin 4	Homo sapiens	13-17
28488242-1	2017	Aquaporin-4 (AQP4) is a selective water channel mediating water transport across cell membranes in skeletal muscles.	Water	58-63	aquaporin 4	Homo sapiens	0-11
28488242-1	2017	Aquaporin-4 (AQP4) is a selective water channel mediating water transport across cell membranes in skeletal muscles.	Water	58-63	aquaporin 4	Homo sapiens	13-17
28166210-4	2017	Tpx2 further activates AurA by stabilizing a water-mediated allosteric network that links the C-helix to the active site through an unusual polar residue in the regulatory spine.	Water	45-50	TPX2 microtubule nucleation factor	Homo sapiens	0-4
28166210-5	2017	The polar spine residue and water network of AurA are essential for phosphorylation-driven activation, but an alternative form of the water network found in related kinases can support Tpx2-driven activation, suggesting that variations in the water-mediated hydrogen bond network mediate regulatory diversification in protein kinases.	Water	134-139	TPX2 microtubule nucleation factor	Homo sapiens	185-189
28166210-5	2017	The polar spine residue and water network of AurA are essential for phosphorylation-driven activation, but an alternative form of the water network found in related kinases can support Tpx2-driven activation, suggesting that variations in the water-mediated hydrogen bond network mediate regulatory diversification in protein kinases.	Water	134-139	TPX2 microtubule nucleation factor	Homo sapiens	185-189
28190227-6	2017	Water-soluble CoQ10 prevented mitochondrial dynamic imbalance by reducing Drp1 and Fis1 protein expression to pre-rotenone levels, as well as reducing rotenone treatment-associated mitochondrial fragmentation.	Water	0-5	collapsin response mediator protein 1	Mus musculus	74-78
28452768-8	2017	Also, the adsorption efficiencies of 70.7, 73.5 and 67.3% were observed for river water, tap water and wastewater effluent, respectively.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
28198191-6	2017	RCI and beta-cyclodextrin were extruded from the film surface and formed teardrops, which were erased by water on the GAFW surface but appeared on the glucamylase-added film without water immersion (GAF).	Water	105-110	fibroblast growth factor 9	Homo sapiens	118-121
28198191-10	2017	The increasing of water holding capacity determined by EDX presented the following order: GAF, GFFW, GFF, and GAFW.	Water	18-23	fibroblast growth factor 9	Homo sapiens	90-93
28115344-2	2017	Raoultella ornithinolytica with blaKPC-2 was also detected in well water from the same area.	Water	67-72	KPC-2	Escherichia coli	32-40
34416665-4	2021	Herein, we report our further medicinal chemistry effort to obtain a highly water-soluble erlotinib analog 5k (>100 mg/mL) with significantly enhanced inhibitory activity against LSD1 (IC50 = 0.69 muM) as well as higher specificity.	Water	76-81	lysine demethylase 1A	Homo sapiens	179-183
28072485-1	2017	Water-soluble polymer nanoparticles NP-1 and NP-2 were prepared by using a three-component self-assembly of an iridium complex, poly(4-vinyl pyridine-b-ethylene oxide) (P4VP-b-PEO), and methane sulfonic acid (MSA).	Water	0-5	neuropilin 2	Mus musculus	45-49
34926375-3	2021	A cross-sectional study was conducted to identify and characterize Campylobacter species in humans, animals and water sources in livestock owning households of peri-urban Addis Ababa, Ethiopia; and to characterize antimicrobial resistance.	Water	112-117	perilipin 1	Homo sapiens	160-164
34874901-0	2021	Assessment of radiation dose hazards caused by radon and its progenies in tap water by the human dosimetric model.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
34874901-2	2021	In this study, the radon concentration in the tap water of residential buildings was measured, and the average value was 543.33 mBq L-1, which was in line with the radon concentration limit recommended by USEPA (11.11 Bq L-1) and EURATOM (100 Bq L-1), and also within the range of the results of radon concentration measurements in tap water in other countries or regions.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
26691867-6	2017	Finally, we found that a small molecule GLO1 inhibitor (S-bromobenzylglutathione cyclopentyl diester (pBBG; 6.25, 12.5 mg/kg)) reduced EtOH consumption compared to vehicle treated B6 mice without altering saccharin or water consumption.	Water	218-223	glyoxalase 1	Mus musculus	40-44
34874903-4	2021	We evaluated consumer perceptions of tap water using weekly social media data.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
34874907-0	2021	Demographic differences in use of household tap water in a representative sample of US adults, FallStyles 2019.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
34874907-1	2021	Tap water that is safe to consume may cause respiratory illness (e.g., Legionnaires" disease) when water conditions allow for proliferation and aerosolization of biofilm-associated pathogens.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
34874907-2	2021	This study assessed household tap water consumption, exposure to aerosolized tap water, and associated demographics.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
34874907-2	2021	This study assessed household tap water consumption, exposure to aerosolized tap water, and associated demographics.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
34874907-5	2021	Respondents were asked about self-reported use of household tap water for consumption (i.e., drinking, rinsing produce, or making ice) and use through water-aerosolizing devices (e.g., showerheads, humidifiers).	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
34874907-7	2021	Weighted analyses using complex sample survey procedures were used to assess tap water exposure by route and demographics.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
34615375-1	2021	OBJECTIVE: We measured the turnover rates of the LDLR (low-density lipoprotein receptor) and PCSK9 (proprotein convertase subtilisin/kexin type 9) in mice by metabolic labeling with heavy water and mass spectrometry.	Water	188-193	low density lipoprotein receptor	Mus musculus	49-53
34615375-1	2021	OBJECTIVE: We measured the turnover rates of the LDLR (low-density lipoprotein receptor) and PCSK9 (proprotein convertase subtilisin/kexin type 9) in mice by metabolic labeling with heavy water and mass spectrometry.	Water	188-193	low density lipoprotein receptor	Mus musculus	55-87
34560931-4	2021	The prepared St-g-PDMC-LPUV flocculant with non-toxic, biodegradability and environmental friendliness exhibited effective performance for removing HA from water in a wide pH range (5-10).	Water	156-161	chromosome 6 open reading frame 15	Homo sapiens	13-17
34375480-9	2021	The Ang (1-7) induced increases in sodium and water excretion were impaired in the SHR group in the context of an unstimulated RAS.	Water	46-51	angiogenin	Rattus norvegicus	4-12
34874907-8	2021	Most US adults are exposed to aerosolized tap water through showering (80.6%), and one in five are exposed through other water-aerosolizing devices (20.3%).	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
34874907-10	2021	Aerosolized tap water can transmit waterborne pathogens and cause respiratory illness, especially among older age groups and people with weakened immune systems.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
27865532-10	2017	CONCLUSION: In the absence of a stationary cooling method such as cold-water immersion, tarp-assisted cooling can serve as an alternative, field-expedient method to provide on-site cooling with a satisfactory cooling rate.	Water	71-76	TCR gamma alternate reading frame protein	Homo sapiens	88-92
34711906-2	2021	Diagnosis of NMOSD is supported by the detection of IgG autoantibodies that target the aquaporin 4 (AQP4) water channel, which, in the CNS, is an astrocyte-specific protein.	Water	106-111	aquaporin 4	Homo sapiens	87-98
34711906-2	2021	Diagnosis of NMOSD is supported by the detection of IgG autoantibodies that target the aquaporin 4 (AQP4) water channel, which, in the CNS, is an astrocyte-specific protein.	Water	106-111	aquaporin 4	Homo sapiens	100-104
34364217-5	2021	RESULTS: All PFASs listed in the German guideline for drinking water (German Environment Agency, 2017) affected the T4 binding to TTR, an important plasma thyroid hormone transport protein.	Water	63-68	transthyretin	Homo sapiens	130-133
34713942-6	2021	For the first time, we show that Giot1 acts to regulate water and salt intake as well as hormone secretion after dehydration.	Water	56-61	gonadotropin inducible ovarian transcription factor 1	Rattus norvegicus	33-38
28056449-10	2017	The significance of Cl2 was noticeable in water containing chloride.	Water	42-47	endogenous retrovirus group W member 5	Homo sapiens	20-23
34713942-14	2021	Giot1 knockdown in PVN reduced water and saline intake as well as AVP and OXT secretion.	Water	31-36	gonadotropin inducible ovarian transcription factor 1	Rattus norvegicus	0-5
34967854-8	2021	Conclusions: Our data demonstrate the therapeutic effect of IL-38 on EAU, and suggest that the effect of IL-38 may be caused by dampening of the GM-CSF/IL-23R/IL-23 feedback loop between Th17 cells and APCs.	Water	69-72	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	145-151
34779471-1	2021	Herein, we report a green, expeditious, and practically simple protocol for direct coupling of carboxylate salts and ammonium salts under ACN/H2O conditions at room temperature without the addition of tertiary amine bases.	Water	142-145	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	138-141
34152558-4	2021	Considering the cotton boll-leaf system (BLS: including the main-stem leaf, sympodial leaves, and non-leaf organs) as the basic unit of the cotton canopy, we speculated that the formation of SBW may depend on photosynthesis in the corresponding BLS under water stress.	Water	255-260	regulatory factor X associated ankyrin containing protein	Homo sapiens	41-44
34152558-4	2021	Considering the cotton boll-leaf system (BLS: including the main-stem leaf, sympodial leaves, and non-leaf organs) as the basic unit of the cotton canopy, we speculated that the formation of SBW may depend on photosynthesis in the corresponding BLS under water stress.	Water	255-260	regulatory factor X associated ankyrin containing protein	Homo sapiens	245-248
34152558-8	2021	The area of the BLS decreased gradually with increasing water stress, and the area of sympodial leaves decreased more than that of the main-stem leaves.	Water	56-61	regulatory factor X associated ankyrin containing protein	Homo sapiens	16-19
34152558-9	2021	Gas exchange showed that the photosynthetic rate of the BLS (Pn(BLS)) decreased gradually with increasing water stress.	Water	106-111	regulatory factor X associated ankyrin containing protein	Homo sapiens	56-59
34152558-9	2021	Gas exchange showed that the photosynthetic rate of the BLS (Pn(BLS)) decreased gradually with increasing water stress.	Water	106-111	regulatory factor X associated ankyrin containing protein	Homo sapiens	64-67
34485782-5	2021	The shape of the S-protein becomes more prolate during the adsorption but this trend, albeit less pronounced, is observed also for the freely relaxing S-protein in water.	Water	164-169	vitronectin	Homo sapiens	151-160
34485782-9	2021	The new intramolecular hydrogen bonds formed during the S-protein adsorption replace the S-protein-water hydrogen bonds; this trend though less apparent, is observed also during the relaxation of the free S-protein in water.	Water	99-104	vitronectin	Homo sapiens	89-98
34485782-9	2021	The new intramolecular hydrogen bonds formed during the S-protein adsorption replace the S-protein-water hydrogen bonds; this trend though less apparent, is observed also during the relaxation of the free S-protein in water.	Water	99-104	vitronectin	Homo sapiens	205-214
34485782-9	2021	The new intramolecular hydrogen bonds formed during the S-protein adsorption replace the S-protein-water hydrogen bonds; this trend though less apparent, is observed also during the relaxation of the free S-protein in water.	Water	218-223	vitronectin	Homo sapiens	205-214
28192370-10	2017	The loaded C3(H2O) represents a source of C3a, and its uptake altered the cytokine profile of activated CD4+ T cells.	Water	14-17	complement C3	Homo sapiens	42-45
34884788-11	2021	On the other hand, B2 can enhance its water absorption ability by increasing the expression of aquaporin genes ZmPIP1-1 and ZmPIP1-5.	Water	38-43	aquaporin PIP1-5	Zea mays	124-132
34152558-13	2021	Thus, the formation of SBW mainly depends on Pn(BLS) under water stress, and the increase of BLS to boll is also helpful to maintain SBW to some extent.	Water	59-64	regulatory factor X associated ankyrin containing protein	Homo sapiens	48-51
34885741-6	2021	The last system considered is an ionic liquid completely miscible with water that combines the cation N-methyl-N,N,N-tris(2-hydroxyethyl)ammonium (N1 2OH 2OH 2OH)+, with high hydrogen-bonding capability, and the hydrophobic anion (NTf2)-.	Water	71-76	nuclear transport factor 2	Homo sapiens	231-235
34912778-1	2021	Cellulose, as a green and available phytochemical, was immobilized on the surface of magnetite nanoparticles then doped with imidazole and Co. complex (Fe3O4@CNF ~ ImSBL ~ Co.) and used as a water-dispersible, recyclable and efficient nano catalyst for the synthesis of C-C cross-coupling reactions including fluoride-free Hiyama and Suzuki reactions in an aqueous medium as an efficient and vital solvent, due to their high application and importance in various fields of science.	Water	191-196	NPHS1 adhesion molecule, nephrin	Homo sapiens	158-161
28253085-0	2017	Water pipe (Shisha, Hookah, Arghile) Smoking and Secondhand Tobacco Smoke Effects on CYP1A2 and CYP2A6 Phenotypes as Measured by Caffeine Urine Test.	Water	0-5	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	96-102
34852310-17	2022	CONCLUSION: aPDT adjunctive to MD improved periodontal parameters i.e., plaque index, pocket depth, and crestal bone loss along with metabolic marker RANK-L in water pipe smokers compared to non piped smokers.	Water	160-165	TNF superfamily member 11	Homo sapiens	150-156
34303235-0	2021	Hazardous inorganic disinfection by-products in Egypt"s tap drinking water: Occurrence and human health risks assessment studies.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	56-59
27269370-1	2017	16-Dehydropregnenolone (16-DHP) is an active compound with an unsatisfied in vivo behavior and poor water-solubility, which limits its clinical application.	Water	100-105	dihydropyrimidinase	Rattus norvegicus	27-30
34303235-1	2021	This study is the first that monitored the presence and levels of chlorite, chlorate and bromate in tap drinking water of Egypt.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	100-103
34303235-9	2021	This study manifested the importance of routine monitoring, and implementing counter measures to control the levels of the hazardous inorganic DBPs in tap drinking water.	Water	164-169	nuclear RNA export factor 1	Homo sapiens	151-154
34887234-5	2021	The prediction was that treated water would result in increased cell proliferation, that more cells would enter the cell cycle growth phase, and that there would be increased expression of genes (NANOG, OCT4 and SOX2) associated with improved cell growth and decreased expression of genes (p16, p21, and p53) associated with a decline in cell growth.	Water	32-37	Nanog homeobox	Homo sapiens	196-201
34887716-2	2021	The water extract of Lycium barbarum berry (Lyc), containing water-soluble Lycium barbarum polysaccharides and flavonoids, can protect the neuronal injury by reducing oxidative stress and suppressing neuroinflammation.	Water	4-9	CD8 antigen, beta chain 1	Mus musculus	44-47
34887716-2	2021	The water extract of Lycium barbarum berry (Lyc), containing water-soluble Lycium barbarum polysaccharides and flavonoids, can protect the neuronal injury by reducing oxidative stress and suppressing neuroinflammation.	Water	61-66	CD8 antigen, beta chain 1	Mus musculus	44-47
34887234-5	2021	The prediction was that treated water would result in increased cell proliferation, that more cells would enter the cell cycle growth phase, and that there would be increased expression of genes (NANOG, OCT4 and SOX2) associated with improved cell growth and decreased expression of genes (p16, p21, and p53) associated with a decline in cell growth.	Water	32-37	SRY-box transcription factor 2	Homo sapiens	212-216
28132510-10	2017	This indicates that due to the tight packing of lipid molecules, particularly the head parts, in the gel phase, HN3 molecules mostly stay near the choline group of lipid and interact with water molecules in the vicinity of choline groups.	Water	188-193	MT-RNR2 like 3 (pseudogene)	Homo sapiens	112-115
34757758-1	2021	The dissociation of a single water molecule on a ZnO(1010) surface has been investigated at the atomic level by low temperature STM manipulation combined with DFT calculations.	Water	29-34	sulfotransferase family 1A member 3	Homo sapiens	128-131
28117978-2	2017	On the basis of the substantial signal amplification by metallo-toehold-triggered, catalytic hairpin assembly (CHA) formation of three-way DNAzyme junctions, we have constructed a highly selective and sensitive fluorescent sensing system for the determination of Hg2+ in different environmental water samples.	Water	295-300	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	263-266
34947816-2	2021	Here we present the studies of several native chemokine receptors including CCR5, CCR9, CXCR2 and CXCR4 determined by X-ray crystallography, and their water-soluble QTY counter parts predicted by AlphaFold2.	Water	151-156	C-C motif chemokine receptor 5	Homo sapiens	76-80
34385133-3	2021	The total mean concentrations of BSHs were 53.32 mug m-3, 36.29 mug m-3, and 26.88 mug L-1 in indoor air, ambient air, and tap water, respectively.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
34808511-8	2021	Water fluoride concentrations were positively associated with AChE and negatively associated with ChAT and ACh, trends were same for urinary fluoride except for ACh.	Water	0-5	choline O-acetyltransferase	Homo sapiens	98-102
34782976-2	2022	The Lesser Zap River is the main tributary of the Tigris and is used as a main source of drinking water in Kirkuk city through the General Kirkuk project.	Water	98-103	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	11-14
28117978-5	2017	The developed sensing method offers high selectivity toward the target Hg2+ over other possible competing metal ions due to the specific T-Hg2+-T bridge structure chemistry in the metallo-toehold domain, and reliable detection of spiked Hg2+ in environmentally relevant water samples with this method is also verified.	Water	270-275	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	71-74
28132505-0	2017	Control of Electrons" Spin Eliminates Hydrogen Peroxide Formation During Water Splitting.	Water	73-78	spindlin 1	Homo sapiens	22-26
34753987-2	2021	Most NMOSD patients are seropositive for immunoglobulin G (IgG) autoantibodies against astrocyte water channel aquaporin-4 (AQP4), called AQP4-IgG.	Water	97-102	aquaporin 4	Homo sapiens	124-128
34753987-2	2021	Most NMOSD patients are seropositive for immunoglobulin G (IgG) autoantibodies against astrocyte water channel aquaporin-4 (AQP4), called AQP4-IgG.	Water	97-102	aquaporin 4	Homo sapiens	138-142
27837334-8	2017	In anhedonic mice, the expression of the water channel aquaporin 4 (AQP4), a factor in glymphatic pathway dysfunction, was down-regulated in cortex and hippocampus.	Water	41-46	aquaporin 4	Mus musculus	68-72
34757813-1	2021	It is hypothesized that L-arginine (ARG) can improve etoposide (VP-16) water solubility while preserving its anticancer activity.	Water	71-76	host cell factor C1	Homo sapiens	64-69
34468057-9	2021	When participants consumed 500mL of tap water, the enrichment of saliva specimens reached a new plateau value faster than urine.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
34827142-7	2021	Additionally, PAB19 inoculation reduced two stressor metabolites, proline and malondialdehyde, and antioxidant enzymes (POD, SOD, CAT, and GR) levels in V. radiata foliage in water stress conditions.	Water	175-180	catalase	Vigna radiata	130-133
26272113-8	2017	Taking into account the fact that non-ciliated cells are well developed with subapical secretory vesicles as well as endosomes, AQP5 may also participate in the secretion and endocytosis in addition to water movement through non-ciliated secretory cells.	Water	202-207	aquaporin 5	Mus musculus	128-132
34771133-5	2021	Specifically for the surface-active species Br-(aq), I-(aq), ClO4-(aq), and SCN-(aq), and also for ClO-(aq), the charge-transfer (CT) energy is found to be larger at the interface than it is in bulk water, by an amount that is greater than the standard deviation of the fluctuations.	Water	199-204	sorcin	Homo sapiens	76-79
34111633-1	2021	This study describes a versatile, robust and fast sample pre-concentration novel method based on chemical vapour deposition grown iron nanoparticles dispersed hierarchical carbon fiber forest (Fe-ACF/CNF) for the determination of multi-pesticide residue in water samples.	Water	257-262	NPHS1 adhesion molecule, nephrin	Homo sapiens	193-203
34111633-5	2021	The Fe-ACF/CNF is competent enough to extract twenty-nine pesticides of different physico-chemical characteristics from water samples.	Water	120-125	NPHS1 adhesion molecule, nephrin	Homo sapiens	4-14
34111633-10	2021	The obtained results are also cross verified with real water samples from the Gomti river (Lucknow, India) and shown the excellent extraction efficiency of Fe-ACF/CNF.	Water	55-60	NPHS1 adhesion molecule, nephrin	Homo sapiens	156-166
28952254-7	2017	It was also found that when the mass concentration of water-soluble azone in the perfusion liquid increased from 5 g L-1 to 20 g L-1, the absorption rate constant was gradually increased and peaked at 20 g L-1.	Water	54-59	ribosomal protein L4	Rattus norvegicus	117-120
34470147-2	2021	As bulk water travels from source to tap, it may accumulate contaminants of emerging concern (CECs) such as antibiotics and heavy metals.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	37-40
34771379-8	2021	Additionally, the results of the solvent distribution around Sgamma, Hgamma, Ndelta1 and Hdelta1 atoms of the catalytic residues Cys145 and His41 showed a low and high-water affinity at acidic pH, respectively.	Water	168-173	delta like canonical Notch ligand 1	Homo sapiens	89-96
28952254-7	2017	It was also found that when the mass concentration of water-soluble azone in the perfusion liquid increased from 5 g L-1 to 20 g L-1, the absorption rate constant was gradually increased and peaked at 20 g L-1.	Water	54-59	ribosomal protein L4	Rattus norvegicus	129-132
34474133-1	2021	Modulation of the aquaporin 4 (AQP4) water-regulatory channel or production of autoantibodies against this protein have been implicated in a variety of neuropsychiatric conditions, and possible mechanisms have been proposed.	Water	37-42	aquaporin 4	Homo sapiens	18-29
34474133-1	2021	Modulation of the aquaporin 4 (AQP4) water-regulatory channel or production of autoantibodies against this protein have been implicated in a variety of neuropsychiatric conditions, and possible mechanisms have been proposed.	Water	37-42	aquaporin 4	Homo sapiens	31-35
34171587-4	2021	Air pollutants (particulate matter, oxygen radicals, hydrocarbons and volatile organic compounds) and water pollutants (metals and organic chemicals) can also intensify Th1/Th17 immune response and could exacerbate SARS-CoV-2 related respiratory distress and failure.	Water	102-107	negative elongation factor complex member C/D	Homo sapiens	169-172
28952254-7	2017	It was also found that when the mass concentration of water-soluble azone in the perfusion liquid increased from 5 g L-1 to 20 g L-1, the absorption rate constant was gradually increased and peaked at 20 g L-1.	Water	54-59	ribosomal protein L4	Rattus norvegicus	129-132
28952254-8	2017	When the mass concentration was increased to 30 g L-1, the absorption rate constant was decreased, indicating that the best mass concentration of water-soluble azone was 20 g L-1.	Water	146-151	ribosomal protein L4	Rattus norvegicus	50-53
28952254-8	2017	When the mass concentration was increased to 30 g L-1, the absorption rate constant was decreased, indicating that the best mass concentration of water-soluble azone was 20 g L-1.	Water	146-151	ribosomal protein L4	Rattus norvegicus	175-178
34252429-10	2021	This study reveals efficient toxic Cr6+ removal from effluent using magnetite carbon nanocomposites which extends their application in waste water treatment.	Water	141-146	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	35-38
34537948-1	2021	The tropical island of Sri Lanka, with a land area of 65,610 km2 and 1340 km of coastline, is highly vulnerable to impacts of climate change, with detrimental effects on agriculture, water resources, human health, coastal zones, infrastructure, industry, and biodiversity.	Water	183-188	sorcin	Homo sapiens	23-26
28051307-0	2017	Highly Efficient Magnetic Nitrogen-Doped Porous Carbon Prepared by One-Step Carbonization Strategy for Hg2+ Removal from Water.	Water	121-126	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	103-106
34082230-5	2021	Pressure solution is promoted when the interfacial water layers of calcite remain undisturbed under stress (e.g. with Ca(II)) and the dissolved ions and water lubricate the interface - a phenomenon called pressure-solution facilitated slip.	Water	51-56	carbonic anhydrase 2	Homo sapiens	118-124
34694651-7	2021	Moreover, both male and female Npff-/- mice exhibited increased water intake resulting from increases in drinking size, rather than number of drinking events.	Water	64-69	neuropeptide FF-amide peptide precursor	Mus musculus	31-35
28158004-2	2017	The micro-LED has a peak emission wavelength of ~440 nm and an underwater power attenuation of 1 dB/m in tap water.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	105-108
34606658-2	2021	AtBBX21 overexpressing (BBX21-OE) potato (Solanum tuberosum) plants, cultivated in optimal water conditions, have higher photosynthesis rate and stomatal conductance without penalty in water use efficiency (WUE) and with a higher tuber yield.	Water	91-96	salt tolerance homolog2	Arabidopsis thaliana	24-29
28190022-0	2017	Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function.	Water	24-29	ataxin 1	Mus musculus	9-13
34175611-11	2021	The present study provides crucial information for simulating the environmental behaviors of PFAAs under the influence of ship navigation and is significant for the integration of inland water transport development and aquatic environmental protection.	Water	187-192	inositol polyphosphate-5-phosphatase D	Homo sapiens	122-126
27966811-1	2017	Visible-light irradiation of a ternary hybrid catalyst prepared by grafting a dye, an H2 evolving CoIII catalyst and a CO-producing ReI catalyst on TiO2 have been found to produce both H2 and CO (syngas) in CO2 -saturated N,N-dimethyl formamide (DMF)/water solution containing a 0.1 m sacrificial electron donor.	Water	251-256	relaxin 2	Homo sapiens	185-194
34382413-6	2021	RESULTS: There were multiple differential methylation sites (DMS) of HLA-DPB1 and PDCD1LG2 genes in the total case and control population and the case and health control population with different water iodine levels.	Water	196-201	programmed cell death 1 ligand 2	Homo sapiens	82-90
34382413-7	2021	Some target regions of HLA-DPB1 and PDCD1LG2 genes were negatively correlated with relative mRNA expression in the total case and control populations and in the case and control population with different water iodine levels.	Water	204-209	programmed cell death 1 ligand 2	Homo sapiens	36-44
34382413-9	2021	The methylation patterns of HLA-DPB1 and PDCD1LG2 genes related to cell adhesion molecule pathway may be different under different areas with different water iodine levels.	Water	152-157	programmed cell death 1 ligand 2	Homo sapiens	41-49
34327801-2	2021	This research aims to determine the total water intake of a representative Australian population, per kilogram of body weight (mL/kg) and stratified by age and sex.	Water	42-47	thrombopoietin	Mus musculus	127-129
34327801-6	2021	RESULTS: The median (interquartile range) daily total water intake per kilogram of body weight for children (2-8 years), adolescents (9-18 years) and adults (19+ years) were 77.1 (57.4-100) mL/kg, 40.4 (29.3-53.4) mL/kg and 35.5 mL/kg (26.1-47.8), respectively.	Water	54-59	thrombopoietin	Mus musculus	190-192
34327801-6	2021	RESULTS: The median (interquartile range) daily total water intake per kilogram of body weight for children (2-8 years), adolescents (9-18 years) and adults (19+ years) were 77.1 (57.4-100) mL/kg, 40.4 (29.3-53.4) mL/kg and 35.5 mL/kg (26.1-47.8), respectively.	Water	54-59	thrombopoietin	Mus musculus	214-216
34327801-7	2021	Increasing height and waist circumference were associated with reduced total water intake, with a change of -1.03 mL/kg (-1.43, -0.618) (coefficient (95% confidence interval)) in children for height and -0.448 mL/kg (-0.484, -0.412) in adults for waist circumference.	Water	77-82	thrombopoietin	Mus musculus	114-116
34327801-7	2021	Increasing height and waist circumference were associated with reduced total water intake, with a change of -1.03 mL/kg (-1.43, -0.618) (coefficient (95% confidence interval)) in children for height and -0.448 mL/kg (-0.484, -0.412) in adults for waist circumference.	Water	77-82	thrombopoietin	Mus musculus	210-212
28073257-5	2017	Using neutron reflectivity (NR), we provide evidence of how substrate pores host the bulky water-soluble domain of hAQP4, which is shown to extend 7.2 nm into the pores of the substrate.	Water	91-96	aquaporin 4	Homo sapiens	115-120
34327801-10	2021	CONCLUSIONS: Total water intake (mL/kg) decreased with age in both sexes.	Water	19-24	thrombopoietin	Mus musculus	33-35
34606658-0	2021	BBX21 reduces ABA sensitivity, mesophyll conductance and chloroplast electron transport capacity to increase photosynthesis and water use efficient in potato plants cultivated under moderated drought.	Water	128-133	salt tolerance homolog2	Arabidopsis thaliana	0-5
34606658-2	2021	AtBBX21 overexpressing (BBX21-OE) potato (Solanum tuberosum) plants, cultivated in optimal water conditions, have higher photosynthesis rate and stomatal conductance without penalty in water use efficiency (WUE) and with a higher tuber yield.	Water	91-96	salt tolerance homolog2	Arabidopsis thaliana	0-7
34606658-2	2021	AtBBX21 overexpressing (BBX21-OE) potato (Solanum tuberosum) plants, cultivated in optimal water conditions, have higher photosynthesis rate and stomatal conductance without penalty in water use efficiency (WUE) and with a higher tuber yield.	Water	185-190	salt tolerance homolog2	Arabidopsis thaliana	24-29
34606658-4	2021	We found that 42-d-old plants of BBX21-OE were more tolerant to water restriction with higher levels of chlorophylls and tuber tuber yield than wild-type spunta (WT) plants.	Water	64-69	salt tolerance homolog2	Arabidopsis thaliana	33-38
34606658-5	2021	In addition, the BBX21-OE lines showed higher photosynthesis rates and WUE under water restriction during the morning.	Water	81-86	salt tolerance homolog2	Arabidopsis thaliana	17-22
34689287-1	2021	Health risks associated with excessive intake of fluoride through drinking water are one of the geoenvironmental health problems observed in many parts of the world, mainly in countries of the humid tropical belt, including Sri Lanka.	Water	75-80	sorcin	Homo sapiens	224-227
34157526-11	2021	Our studies suggest that soluble components in Salton Sea water promote induction of a unique inflammation-associated response, though any relationship to asthma remains to be explored.	Water	58-63	sepia	Mus musculus	54-57
34606658-7	2021	By RNAseq analysis, we found 204 genes whose expression decreased by drought in WT plants and expressed independently of the water condition in BBX21-OE lines as SAP12, MYB73, EGYP1, TIP2-1 and DREB2A which expression were confirmed by qPCR.	Water	125-130	salt tolerance homolog2	Arabidopsis thaliana	144-149
27499328-7	2017	Our own studies on this subject are enabled by the application of magnetic resonance relaxometry methods relying on spin labels tethered to polyelectrolyte constituents or added as spin labeled probe molecules that partition into the dense versus the equilibrium coacervate phase, permitting the extraction of information on local polymer dynamics, polymer packing and local water dynamics.	Water	375-380	spindlin 1	Homo sapiens	116-120
34606658-8	2021	These results suggest that BBX21 interplays with the ABA and growth signaling networks improving the photosynthetic behavior in suboptimal water conditions with an increase in potato tuber yield.	Water	139-144	salt tolerance homolog2	Arabidopsis thaliana	27-32
34596383-5	2021	We find that a mutation that destabilizes GB1 in solution does not affect its dehydrated structure, whereas a mutation that stabilizes CI2 in solution makes several regions of the protein more susceptible to dehydration-induced unfolding, suggesting that water is primarily responsible for the destabilization of the GB1 variant but plays a stabilizing role in the CI2 variant.	Water	255-260	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	42-45
34596383-5	2021	We find that a mutation that destabilizes GB1 in solution does not affect its dehydrated structure, whereas a mutation that stabilizes CI2 in solution makes several regions of the protein more susceptible to dehydration-induced unfolding, suggesting that water is primarily responsible for the destabilization of the GB1 variant but plays a stabilizing role in the CI2 variant.	Water	255-260	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	317-320
34641764-4	2021	In addition, in tap water and municipal wastewater scenarios, 100% and 90.07% removal of BPA were obtained, respectively, and MCS exhibited outstanding performance after repeated use.	Water	20-25	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	126-129
27499328-7	2017	Our own studies on this subject are enabled by the application of magnetic resonance relaxometry methods relying on spin labels tethered to polyelectrolyte constituents or added as spin labeled probe molecules that partition into the dense versus the equilibrium coacervate phase, permitting the extraction of information on local polymer dynamics, polymer packing and local water dynamics.	Water	375-380	spindlin 1	Homo sapiens	181-185
34679775-9	2021	Molecular docking studies of the enzyme-inhibitor binding complexes in MAO-B revealed that free NH and substituted indole derivatives share a common favorable binding mode: H-bonding with a crucial water "anchor" and Tyr326.	Water	198-203	monoamine oxidase B	Rattus norvegicus	71-76
28258567-4	2017	AQP4, the predominant water channel in the CNS, is involved both in the astrocyte swelling of cytotoxic edema and the resolution of vasogenic edema, and is of pivotal importance in the pathology of brain disorders such as neuromyelitis optica , brain tumors and Alzheimer"s disease.	Water	22-27	aquaporin 4	Homo sapiens	0-4
34460232-6	2021	It subsequently was applied for the analysis of multi-SEs from three real samples in the environment including medical wastewater, river water, and tap water to provide a means to clarify the fate of multi-SEs in the process of migration and transformation.	Water	152-157	nuclear RNA export factor 1	Homo sapiens	148-151
34765796-4	2021	Moreover, superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase enzyme activities, as well as reduced glutathione and malondialdehyde levels were significantly increased in heavy metals contained river water treated fish compared to the control.	Water	230-235	catalase	Oreochromis niloticus	32-40
28231743-4	2017	Here we found that water extract of Glycyrrhizae radix (GR) inhibits receptor activator of nuclear factor-[Formula: see text]B ligand (RANKL)-induced osteoclast differentiation in a dose-dependent manner without causing cytotoxicity.	Water	19-24	TNF superfamily member 11	Homo sapiens	135-140
34157324-1	2021	ETHNOPHARMACOLOGICAL RELEVANCE: Salvianolic acid A (SAA) is extracted from traditional Chinese medicine Salvia miltiorrhiza and is the main water-soluble and the biologically active ingredient.	Water	140-145	serum amyloid A1 cluster	Homo sapiens	52-55
34648161-3	2022	Therefore, the objectives of this research were to (a) use a Geographic Information System (GIS) to designate spatial distribution of various water physicochemical characteristics, (b) detect "suitable" groundwater zones for drinking, and (c) estimate groundwater quality by developing a groundwater quality index (GWQI) in Sri Lanka"s urban coastal region.	Water	142-147	sorcin	Homo sapiens	324-327
34682361-1	2021	The perceived safety of tap water is an important condition for consumers to drink it.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
34644503-9	2021	In the present cases, water also provides a driving force in the layer-to-tube transformation.	Water	22-27	tubulin epsilon 1	Homo sapiens	74-78
28302987-0	2017	Development of a Certified Reference Material (NMIJ CRM 7203-a) for Elemental Analysis of Tap Water.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
34827788-3	2021	To solubilize CORT, it was first dissolved in ethanol and then added to water.	Water	72-77	CORT	Gallus gallus	14-18
28302987-1	2017	A certified reference material (CRM), NMIJ CRM 7203-a, was developed for the elemental analysis of tap water.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
34091333-9	2021	LBP/PVP-ZIF-67 is completely stable in water within 120 h, in contrast to over 30% degradation of LBP or LBP/PVP.	Water	39-44	lipopolysaccharide binding protein	Homo sapiens	0-3
34091333-10	2021	More than 50% of LBP in the LBP/PVP-ZIF-67 can degrade to dissolvable phosphorus in oxygenated water after 17 days, indicating the nanomaterial will not be persistent in the environment.	Water	95-100	lipopolysaccharide binding protein	Homo sapiens	17-20
28164127-5	2017	The apical membrane expression, where NKCC2 is functional, may be sufficient to normalize water, potassium, sodium, and osmolytes tubular handling.	Water	90-95	solute carrier family 12 member 1	Rattus norvegicus	38-43
34608902-1	2021	A monolithic supercapacitor electrode of a KNi0.67Co0.33PO4 H2O-graphene composite hydrogel supported on Ni foam (KNCP-GH/NF) is first prepared by a one-step hydrothermal method, which achieves notable improvements in the electrode surface area and mass-loading of active materials.	Water	60-63	neurofascin	Homo sapiens	114-124
34649435-7	2021	The quantum mechanics/molecular mechanics (QM/MM) calculations herein show that MMP-9 proteolysis is a water-mediated four-step reaction.	Water	103-108	matrix metallopeptidase 9	Homo sapiens	80-85
27812963-3	2017	Carbamazepine and metamizole metabolites N-acetyl-4-amino-antipyrine (4-AAA) and N-formyl-4-amino-antipyrine (4-FAA) have the highest frequency of occurrence in surface water (57.3-68.8 %) and in groundwater (19.5-43.9 %), respectively.	Water	169-174	FA complementation group A	Homo sapiens	112-115
34672539-0	2021	Photocatalytic H2O Overall Splitting into H2 Bubbles by Single Atomic Sulfur Vacancy CdS with Spin Polarization Electric Field.	Water	15-18	spindlin 1	Homo sapiens	94-98
34672539-2	2021	Here, in the absence of cocatalysts, H2O overall splitting has been achieved by single-atomic S vacancy hexagonal CdS with a spin polarization electric field (PEF).	Water	37-40	spindlin 1	Homo sapiens	125-129
34672539-4	2021	By systematically tuning the spin PEF intensity with single-atomic S vacancy content, common pristine CdS is converted to a photocatalyst that can efficiently complete H2O overall splitting by releasing a great number of H2 bubbles under natural solar light.	Water	168-171	spindlin 1	Homo sapiens	29-33
34497177-2	2021	In this study, the solubilisation and complexation behaviours of Toc with methyl-substituted CD derivatives and the radical scavenging ability of the resulting complexes were precisely investigated in water media.	Water	201-206	rhomboid 5 homolog 2	Homo sapiens	65-68
34497177-3	2021	Several problems were encountered upon pre-dissolving Toc in an organic solvent prior to the addition to the water media, such as enhancement of the dispersibility and decrease in the complexation capacity.	Water	109-114	rhomboid 5 homolog 2	Homo sapiens	54-57
34497177-6	2021	However, 2,6-di-O-methylated beta-CD (2,6-DMCD) formed a water-soluble inclusion complex with Toc, effectively enhancing its solubility.	Water	57-62	rhomboid 5 homolog 2	Homo sapiens	94-97
34636561-4	2021	Conversely, decreased proton transfer barriers and a striking propensity of H3O+ and OH- for stationary interfacial water are found.	Water	116-121	H3 clustered histone 15	Homo sapiens	76-79
27812963-4	2017	Highest detected concentrations were for 4-AAA (520 ng/L) and 4-FAA (248 ng/L) in surface water as well as in groundwater (4-AAA 128 ng/L and 4-FAA 150 ng/L).	Water	90-95	FA complementation group A	Homo sapiens	64-67
34375032-6	2021	Finally, the optimized method was applied for determining trace levels of carbazole and 11 polyhalogenated carbazoles in tap water and seawater samples with good recovery of 86.6-112.8%.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
34375032-7	2021	Carbazole and 3-7 polyhalogenated carbazoles were detected, and 3,6-dichlorocarbazole was the predominant congener both in tap water and seawater.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
29081793-6	2017	Additionally, the water jet function of the BT-S was not inferior.	Water	18-23	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	44-48
34676688-0	2021	Enhancement of the RhoA/Rho kinase pathway is associated with stress-related erectile dysfunction in a restraint water immersion stress model.	Water	113-118	ras homolog family member A	Rattus norvegicus	19-23
34632471-0	2021	Theoretical investigation of the SN2 mechanism of X- (X = SH, PH2) + CH3Y (Y = F, Cl, Br, I) reactions in water.	Water	106-111	polyhomeotic homolog 2	Homo sapiens	62-65
34632471-1	2021	We investigated the SN2 Walden-inversion mechanism of X- (X = SH, PH2) + CH3Y (Y = F, Cl, Br, I) reactions in water using multi-level quantum mechanics (ML-QM) and molecular mechanics (MM) methods.	Water	110-115	polyhomeotic homolog 2	Homo sapiens	66-69
27796626-2	2017	Receptor FT displayed a selective colorimetric change (from colorless to orange color) upon binding to Hg2+ in DMSO/H2O (1:9, v/v) solution.	Water	116-119	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	103-106
34632471-3	2021	In particular, for the PH2- + CH3I reaction, although the backside attack Walden-inversion mechanics were not observed in the gas phase, we found that this mechanism takes place in water.	Water	181-186	polyhomeotic homolog 2	Homo sapiens	23-26
34217941-8	2021	Compared with micron-sized water droplets, PM1.0 removal efficiency improved by approximately two times higher.	Water	27-32	transmembrane protein 11	Homo sapiens	43-46
34588880-7	2021	It was observed that the level of cytokines pro-inflammatory (IL-17, IL-6, IL-2, IL-4, INF-gamma) in serum was normalized in mice treated with ICE, which would indicate that polyP prevents the local inflammatory response in the respiratory tract.	Water	143-146	interleukin 17A	Mus musculus	62-67
34903939-1	2021	Background and Aim: Aquaporin-2 (AQP2) and arginine vasopressin receptor-2 (AVPR2) are proteins that control water homeostasis in principal cells.	Water	109-114	arginine vasopressin receptor 2	Canis lupus familiaris	43-74
34903939-1	2021	Background and Aim: Aquaporin-2 (AQP2) and arginine vasopressin receptor-2 (AVPR2) are proteins that control water homeostasis in principal cells.	Water	109-114	arginine vasopressin receptor 2	Canis lupus familiaris	76-81
34903939-12	2021	The central role of specific AQP2 and AVPR2 in regulating water homeostasis will provide correlations in case of CKD with polyuria.	Water	58-63	arginine vasopressin receptor 2	Canis lupus familiaris	38-43
28254461-10	2017	Water isolates (86%) had a higher prevalence of the asa1 gene, which encodes for aggregation substance, whereas clinical (78%) and farm animal isolates (87%) had a higher prevalence of the esp gene, encoding a surface exposed protein.	Water	0-5	aggregation substance	Enterococcus faecalis	52-56
34681089-16	2021	ST1, ST2, ST3, ST4, ST5 and ST6 were shared by humans, animals, and water sources.	Water	68-73	CD82 molecule	Homo sapiens	28-31
34584029-6	2021	Compared the difference between PCL and NRC, the fiber diameter,water contact angle, elongation were all diminished, while tensile strength and Young"s Module were increasing.	Water	64-69	polycomb protein Pcl	Bombyx mori	32-35
27373674-1	2017	Aquaporin-4 (AQP-4) is the predominant water channel in the brain and primarily expressed in astrocytes.	Water	39-44	aquaporin 4	Mus musculus	0-11
34675516-0	2021	Bombesin Peptide Conjugated Water-Soluble Chitosan Gallate-A New Nanopharmaceutical Architecture for the Rapid One-Pot Synthesis of Prostate Tumor Targeted Gold Nanoparticles.	Water	28-33	gastrin releasing peptide	Homo sapiens	0-8
34675516-1	2021	Purpose: We report herein bombesin peptide conjugated water-soluble chitosan gallate as a template for rapid one-pot synthesis of gold nanoparticles (AuNPs) with capabilities to target receptors on prostate cancer cells.	Water	54-59	gastrin releasing peptide	Homo sapiens	26-34
34107028-0	2021	APS reductase and sulfite oxidase regulate sulfite-induced water loss in Arabidopsis.	Water	59-64	APS reductase 1	Arabidopsis thaliana	0-13
34641443-3	2021	Therefore, glutathione (GSH)/ROS (reactive oxygen species) dual-responsive supramolecular nanoparticles (GOx@BNPs) for chemo-chemodynamic combination therapy were constructed via host-guest complexation between water-soluble pillar(6)arene and the ferrocene-modified natural anticancer product betulinic acid (BA) prodrug, followed by encapsulation of glucose oxidase (GOx) in the nanoparticles.	Water	211-216	hydroxyacid oxidase 1	Homo sapiens	105-108
27373674-1	2017	Aquaporin-4 (AQP-4) is the predominant water channel in the brain and primarily expressed in astrocytes.	Water	39-44	aquaporin 4	Mus musculus	13-18
34491058-6	2021	We performed an all-atom large-scale MD simulation in explicit water on the PHF6 dimer and octa-peptides systems using five mainstream force fields, including AMBER99SB-disp, AMBER14SB, CHARMM36m, GROMOS54a7, and OPLSAA.	Water	63-68	PHD finger protein 6	Homo sapiens	76-80
28039592-1	2017	The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state.	Water	101-106	aquaporin 4	Mus musculus	82-93
34607954-5	2021	Upon drinking 4NQO-containing water, Brca1 heterozygous mice formed squamous cell carcinomas of the distal esophagus and forestomach at a much higher frequency and speed (~90 to 120 d) than did wild-type (WT) mice, which remained largely tumor free.	Water	30-35	breast cancer 1, early onset	Mus musculus	37-42
34580316-8	2021	ISK based on morphological observations, and the luminescence spectrum showed a peak at 444 nm, which is an exceptionally short wavelength for bioluminescence in a shallow coastal water environment.	Water	180-185	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	0-3
28039592-1	2017	The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state.	Water	101-106	aquaporin 4	Mus musculus	95-99
28039592-1	2017	The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state.	Water	150-155	aquaporin 4	Mus musculus	82-93
34617156-0	2021	Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI.	Water	24-29	aquaporin 4	Mus musculus	42-53
28039592-1	2017	The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state.	Water	150-155	aquaporin 4	Mus musculus	95-99
34617156-1	2021	BACKGROUND: Aquaporin-4 is a membrane channel protein that is highly expressed in brain astrocytes and facilitates the transport of water molecules.	Water	132-137	aquaporin 4	Mus musculus	12-23
34617156-11	2021	Fitting of the water-exchange model to the ischemic region data found that the water-exchange time in aquaporin-4 knockout mice was approximately 2.5 times longer than that in wild-type mice.	Water	15-20	aquaporin 4	Mus musculus	102-113
34617156-11	2021	Fitting of the water-exchange model to the ischemic region data found that the water-exchange time in aquaporin-4 knockout mice was approximately 2.5 times longer than that in wild-type mice.	Water	79-84	aquaporin 4	Mus musculus	102-113
34310047-0	2021	Low Temperature Methanol-Water Reforming over the Alcohol Dehydrogenase and Immobilized Ruthenium Complex.	Water	25-30	aldo-keto reductase family 1 member A1	Homo sapiens	50-71
34166938-4	2021	Therefore, our study aimed to examine whether the low level of fluoride exposure (measured in blood plasma and household tap water) was associated with the risk of dental fluorosis based on data of the National Health and Nutrition Examination Survey (NHANES) 2015-2016.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
28039592-6	2017	Aqp4 KO increased the effective diffusion coefficient at long diffusion times by 5%, and a 14% decrease in membrane water permeability was estimated for Aqp4 KO compared with WT mice.	Water	116-121	aquaporin 4	Mus musculus	153-157
28260731-8	2017	The restriction orders of food supplies such as contaminated vegetables and milk, and tap water intake were implemented within several days after the major release of radionuclides on March 15, 2011.	Water	90-95	nuclear RNA export factor 1	Homo sapiens	86-89
34603297-8	2021	Adoptive transfer of activated IRBP-specific T cells from untreated EAU mice induced EAU, while EAU was significantly attenuated in mice that received IRBP-specific T cells from SBT-100 treated mice.	Water	68-71	retinol binding protein 3, interstitial	Mus musculus	31-35
34603297-8	2021	Adoptive transfer of activated IRBP-specific T cells from untreated EAU mice induced EAU, while EAU was significantly attenuated in mice that received IRBP-specific T cells from SBT-100 treated mice.	Water	85-88	retinol binding protein 3, interstitial	Mus musculus	31-35
34603297-8	2021	Adoptive transfer of activated IRBP-specific T cells from untreated EAU mice induced EAU, while EAU was significantly attenuated in mice that received IRBP-specific T cells from SBT-100 treated mice.	Water	96-99	retinol binding protein 3, interstitial	Mus musculus	151-155
34175706-7	2021	Besides, owing to the scattered hydrophilic sites of functional groups and NPs on the surface of GA-b/NP, it shows high adhesion properties for water droplets, thus presents great potential in high-efficiency fog collecting materials.	Water	144-149	alpha-1-B glycoprotein	Homo sapiens	97-104
27837803-0	2017	Predicting consumer preferences for mineral composition of bottled and tap water.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
34473843-0	2021	Ferromagnetic-Antiferromagnetic Coupling Core-Shell Nanoparticles with Spin Conservation for Water Oxidation.	Water	93-98	spindlin 1	Homo sapiens	71-75
34371231-7	2021	The results showed that the BGPICC ratio between Tap-water/RO-water was ~7.5, whereas the BGPATP ratio was only ~4.5.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
27837803-1	2017	The overall liking for taste of water was correlated with the mineral composition of selected bottled and tap waters.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	106-109
34371231-7	2021	The results showed that the BGPICC ratio between Tap-water/RO-water was ~7.5, whereas the BGPATP ratio was only ~4.5.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	49-52
28386151-7	2017	Container-grown crop producers can either adopt research-based best management practices proactively to minimize the economic and environmental risk of limited access to high-quality water, be required to change by external factors such as regulations and fines, or adapt production practices over time as a result of changing climate conditions.	Water	183-188	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	16-20
34371231-8	2021	Moreover, the YICC ratio between Tap-water/RO-water was ~2 (9.8 +- 0.6 x 106 vs. 4.6 +- 0.8 x 106 cells/microg-C), whereas the YATP ratio was ~1 (0.39 +- 0.12 vs. 0.42 +- 0.06 ng ATP/microg-C), resulting in a consistently higher ATP per cell in RO-water than that of Tap-water.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
34371231-8	2021	Moreover, the YICC ratio between Tap-water/RO-water was ~2 (9.8 +- 0.6 x 106 vs. 4.6 +- 0.8 x 106 cells/microg-C), whereas the YATP ratio was ~1 (0.39 +- 0.12 vs. 0.42 +- 0.06 ng ATP/microg-C), resulting in a consistently higher ATP per cell in RO-water than that of Tap-water.	Water	248-253	nuclear RNA export factor 1	Homo sapiens	33-36
34371231-8	2021	Moreover, the YICC ratio between Tap-water/RO-water was ~2 (9.8 +- 0.6 x 106 vs. 4.6 +- 0.8 x 106 cells/microg-C), whereas the YATP ratio was ~1 (0.39 +- 0.12 vs. 0.42 +- 0.06 ng ATP/microg-C), resulting in a consistently higher ATP per cell in RO-water than that of Tap-water.	Water	271-276	nuclear RNA export factor 1	Homo sapiens	267-270
34287839-2	2021	The available BCL6 BTB-specific inhibitors are poorly water soluble thus limiting their absorption in vivo and our understanding of therapeutic strategy targeting GC.	Water	54-59	B cell leukemia/lymphoma 6	Mus musculus	14-18
34460995-2	2021	Autoantibodies (NMO-IgG) against the water channel protein, aquaporin 4 (AQP4), are a serologic marker in NMO patients, and they are known to be responsible for the pathophysiology of the disease.	Water	37-42	aquaporin 4	Homo sapiens	60-71
34460995-2	2021	Autoantibodies (NMO-IgG) against the water channel protein, aquaporin 4 (AQP4), are a serologic marker in NMO patients, and they are known to be responsible for the pathophysiology of the disease.	Water	37-42	aquaporin 4	Homo sapiens	73-77
30505039-1	2017	The storage of coal combustion residue (CCR) in surface water impoundments may have an impact on nearby water quality and aquatic ecosystems.	Water	56-61	cal	Drosophila melanogaster	15-19
34216898-0	2021	Assessment of current status and geospatial analysis of compliance to bacteriological parameters: Tools to ensure access to safe water in Sri Lanka.	Water	129-134	sorcin	Homo sapiens	138-141
34557603-1	2021	Aquaporin 4 (AQP4) is an important water channel in the central nervous system which is implicated in several neurological disorders.	Water	35-40	LOW QUALITY PROTEIN: aquaporin-4	Cricetulus griseus	0-11
34557603-1	2021	Aquaporin 4 (AQP4) is an important water channel in the central nervous system which is implicated in several neurological disorders.	Water	35-40	LOW QUALITY PROTEIN: aquaporin-4	Cricetulus griseus	13-17
34424695-0	2021	Proline Isomerization Regulates the Phase Behavior of Elastin-Like Polypeptides in Water.	Water	83-88	elastin	Homo sapiens	54-61
28036023-4	2016	AQP1 and AQP4, the two primary aquaporin molecules of the central nervous system, regulate brain water and CSF movement and contribute to cytotoxic and vasogenic edema, where they control the size of the intracellular and extracellular fluid volumes, respectively.	Water	97-102	aquaporin 4	Homo sapiens	9-13
34292641-9	2021	The ABH platform offers reduced energy and chemical demands for point-of-use water treatment technologies in remote areas and emergency rescue applications.	Water	77-82	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	4-7
34263427-7	2021	Our results showed that AQP4-IgG binding to AQP4 induces its partial internalization, leading to the decrease of the plasma membrane water permeability, a reduction of swelling-induced increase of intracellular calcium levels and the impairment of RVD in Muller cells.	Water	133-138	aquaporin 4	Homo sapiens	24-28
34263427-7	2021	Our results showed that AQP4-IgG binding to AQP4 induces its partial internalization, leading to the decrease of the plasma membrane water permeability, a reduction of swelling-induced increase of intracellular calcium levels and the impairment of RVD in Muller cells.	Water	133-138	aquaporin 4	Homo sapiens	44-48
34589396-7	2021	Upon cleavage, the N-terminus of GsdmD (GsdmD-N) forms a transmembrane pore that releases cytokines such as IL-1beta and IL-18 and disturbs the regulation of ions and water, eventually resulting in strong inflammation and cell death.	Water	167-172	gasdermin D	Mus musculus	33-38
27437951-3	2016	To harness this wasted reductant, we engineered the model cyanobacterium Synechococcus PCC 7002 to express the mammalian cytochrome P450 CYP1A1 to serve as an artificial electron sink for excess electrons derived from light-catalyzed water-splitting.	Water	234-239	tribbles pseudokinase 3	Homo sapiens	179-183
34087188-4	2021	Available historical residential tap water concentrations of THMs and nitrate, available from 3 countries for 86 cases and 352 controls and 85 cases and 343 for nitrate, respectively, were modelled and combined with the study subjects" personal consumption patterns to estimate ingestion and residential exposure levels in the study population (both pre- and postnatal).	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
34087188-9	2021	For nitrate, all ORs were above 1 (OR = 1.80 (0.91-3.55)) for postnatal average residential nitrate levels higher than 8.5 mg/L, with a suggestion of a trend of increased risk of neuroepithelial BTs with increasing residential nitrate levels in tap water, which appeared stronger in early in life.	Water	249-254	nuclear RNA export factor 1	Homo sapiens	245-248
34410689-2	2021	The ADM is an isotropic liquid that self-assembles only when in contact with water.	Water	77-82	adrenomedullin	Homo sapiens	4-7
27451182-7	2016	Samples consisting of bottled water, conditioned in various materials (glass, PET) and subjected to different storage conditions, had no hormone-like activities whereas estrogenic activity was found in the filtered tap water.	Water	219-224	nuclear RNA export factor 1	Homo sapiens	215-218
34551530-8	2021	We then present the first MR-DSRG application on transition-metal complexes by computing the spin splittings of the (Fe(H2O)6)2+ and (Fe(NH3)6)2+ molecules.	Water	120-123	spindlin 1	Homo sapiens	93-97
34250640-6	2021	This observation was in line with previously reported results for (11 C)UCB-J, a tracer for the synaptic vesicle glycoprotein 2A (SV2A) receptor, that also was obtained in higher RCY when synthesized in THF/water.	Water	207-212	synaptic vesicle glycoprotein 2A	Homo sapiens	96-128
27572526-0	2016	Water soluble organic carbon in aerosols (PM1, PM2.5, PM10) and various precipitation forms (rain, snow, mixed) over the southern Baltic Sea station.	Water	0-5	transmembrane protein 11	Homo sapiens	42-45
34433206-12	2021	Significant association was found between disinfecting with tap water (5.98; 95% confidence interval (CI), 1.22 to 29.27; P = .03), heavy visual display terminal use (3.39; 95% CI, 1.01 to 11.34; P = .05), high water content (1.16; 95% CI, 1.02 to 1.33; P = .03), and contact lens discomfort.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
34578876-0	2021	Tap Water Consumption and Perceptions in United States Latinx Adults.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
34551530-10	2021	The FPA based on the linearized MR-DSRG theory with one- and two-body operators and up to a quintuple-zeta basis set predicts the spin splittings of (Fe(H2O)6)2+ and (Fe(NH3)6)2+ to be -35.7 and -17.1 kcal mol-1, respectively, showing good agreement with the results of local CC theory with singles, doubles, and perturbative triples.	Water	153-156	spindlin 1	Homo sapiens	130-134
34082370-0	2021	Assessment of the water quality of groundwater in Bohai Rim and the controlling factors-a case study of northern Shandong Peninsula, north China.	Water	18-23	regulating synaptic membrane exocytosis 1	Homo sapiens	56-59
27132703-9	2016	RESULTS: Nasal CPAP (14.8 +- 4.1 cm H2O) was able to stabilize breathing in all patients.	Water	36-39	centromere protein J	Homo sapiens	15-19
34521831-4	2021	The biosensor, named SED1, utilizes the Arabidopsis intrinsically disordered AtLEA4-5 protein expressed in plants under water deficit.	Water	120-125	Sed1p	Saccharomyces cerevisiae S288C	21-25
34521831-6	2021	SED1 exhibits large and near-linear osmolarity-dependent changes in FRET inside living bacteria, yeast, plant, and human cells, demonstrating the broad utility of this tool for studying water-associated stress.	Water	186-191	Sed1p	Saccharomyces cerevisiae S288C	0-4
34578876-3	2021	While overall plain water intake is similar between Latinx and NH white adults, Latinx adults consistently consume significantly more bottled water and less tap water.	Water	161-166	nuclear RNA export factor 1	Homo sapiens	157-160
34578876-4	2021	The purpose of this review is to identify factors that may contribute to low water intake and low tap water intake, particularly in Latinx adults.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
34578876-6	2021	Plain water preferences appear to be related, in part, to perceptions of tap water safety as Latinx adults are significantly more likely to perceive their tap water as unsafe compared to NH white adults.	Water	6-11	nuclear RNA export factor 1	Homo sapiens	73-76
34578876-6	2021	Plain water preferences appear to be related, in part, to perceptions of tap water safety as Latinx adults are significantly more likely to perceive their tap water as unsafe compared to NH white adults.	Water	6-11	nuclear RNA export factor 1	Homo sapiens	155-158
34578876-6	2021	Plain water preferences appear to be related, in part, to perceptions of tap water safety as Latinx adults are significantly more likely to perceive their tap water as unsafe compared to NH white adults.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
34578876-6	2021	Plain water preferences appear to be related, in part, to perceptions of tap water safety as Latinx adults are significantly more likely to perceive their tap water as unsafe compared to NH white adults.	Water	159-164	nuclear RNA export factor 1	Homo sapiens	155-158
34578876-7	2021	Although recent investigations have not consistently or comprehensively evaluated the same factors, we have compiled their findings to describe the complex, interrelated determinants of tap water safety perceptions in Latinx adults.	Water	190-195	nuclear RNA export factor 1	Homo sapiens	186-189
28095290-13	2016	The authors consider that drinking tap water is perhaps a more appropriate way for newborns, infants, elderly, and people with compromised immunity to satisfy thirst than using bottled water.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
34424345-4	2021	Furthermore, potable water driven from the river had levels of 2-MIB/geosmin and a mud smell/taste.	Water	21-26	MIB E3 ubiquitin protein ligase 1	Homo sapiens	65-68
34126180-1	2021	Aquaporin-4 (AQP4) is the key water channel protein that regulates brain water homeostasis.	Water	30-35	aquaporin 4	Homo sapiens	0-11
34126180-1	2021	Aquaporin-4 (AQP4) is the key water channel protein that regulates brain water homeostasis.	Water	30-35	aquaporin 4	Homo sapiens	13-17
34499128-0	2022	Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis.	Water	73-78	aquaporin 4	Homo sapiens	27-38
34499128-5	2022	Recently, we have demonstrated that AQP4 localization is also dynamically regulated at the subcellular level, affecting membrane water permeability.	Water	129-134	aquaporin 4	Homo sapiens	36-40
34499128-7	2022	CNS oedema is caused by passive water influx through AQP4 in response to osmotic imbalances.	Water	32-37	aquaporin 4	Homo sapiens	53-57
34126180-1	2021	Aquaporin-4 (AQP4) is the key water channel protein that regulates brain water homeostasis.	Water	73-78	aquaporin 4	Homo sapiens	0-11
26810082-1	2016	Tap water from 497 properties using private water supplies, in an area of metalliferous and arsenic mineralisation (Cornwall, UK), was measured to assess the extent of compliance with chemical drinking water quality standards, and how this is influenced by householder water treatment decisions.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
34126180-1	2021	Aquaporin-4 (AQP4) is the key water channel protein that regulates brain water homeostasis.	Water	73-78	aquaporin 4	Homo sapiens	13-17
34126180-2	2021	Polarized expression of AQP4 on the astroglial endfeet facilitates its role in bi-directional brain water flux control.	Water	100-105	aquaporin 4	Homo sapiens	24-28
34430201-2	2021	To achieve fast scanning speed, the OR-PAM system uses a single-axis water-immersible resonant scanning mirror that can confocally scan the optical and acoustic beams at 1018 Hz with a 3-mm range.	Water	69-74	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	39-42
34575909-1	2021	Aquaporin-4 (AQP4) is the principal water channel in the brain being expressed in astrocytes and ependymal cells.	Water	36-41	aquaporin 4	Mus musculus	0-11
34575909-1	2021	Aquaporin-4 (AQP4) is the principal water channel in the brain being expressed in astrocytes and ependymal cells.	Water	36-41	aquaporin 4	Mus musculus	13-17
34423373-1	2021	This study aims to estimate the entrance surface dose (ESD) of a water phantom for kilovoltage x-ray beams using an air kerma area product meter (KAP meter) equipped in an x-ray unit.	Water	65-70	cyclin dependent kinase inhibitor 3	Homo sapiens	146-149
26810082-7	2016	Significant reductions in concentrations of aluminium, cadmium, copper, lead and/or nickel were found in tap waters where households were successfully treating low-pH groundwaters, and similar adventitious results were found for arsenic and nickel where treatment was installed for iron and/or manganese removal, and successful treatment specifically to decrease tap water arsenic concentrations was observed at two properties where it was installed.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	105-108
30356572-1	2016	Purpose: The aim of this study was to investigate the effects of fluid replacement by water or sports drinks on serum heat shock protein 70 (HSP70) levels and DNA damage during exercise at a high ambient temperature.	Water	86-91	heat shock protein family A (Hsp70) member 4	Homo sapiens	118-139
34296610-1	2021	This work describes the synthesis and characterization of a Zn-based metal-organic framework, (Zn2(TTPA)(SDB)2 (DMF)(H2O))n (1, TTPA = tris(4-(1H-1,2,4-triazol-1-yl)phenyl)amine, SDB = 4,4"-sulfonyldibenzoate).	Water	117-120	alpha tocopherol transfer protein	Homo sapiens	99-103
34128962-2	2021	The "glymphatic" mechanism proposes that the astrocyte water channel aquaporin-4 (AQP4) is a major determinant of solute transport between the CSF and the interstitial space; however, this is controversial in part because of wide variance in experimental data on interstitial uptake of cisternally injected solutes.	Water	55-60	aquaporin 4	Mus musculus	82-86
34477697-4	2021	The overall alkaline water splitting using Fe/Bi-NiO/NF as an anode affords low cell voltages of 1.50 and 1.63 V at 10 and 100 mA cm-2, and operates steadily at a high current density of 100 mA cm-2 for 55 h without decay.	Water	21-26	neurofascin	Homo sapiens	53-55
30356572-1	2016	Purpose: The aim of this study was to investigate the effects of fluid replacement by water or sports drinks on serum heat shock protein 70 (HSP70) levels and DNA damage during exercise at a high ambient temperature.	Water	86-91	heat shock protein family A (Hsp70) member 4	Homo sapiens	141-146
34477699-7	2021	Finally, an overall water splitting device using W,Mo-NiCoP/NF as both the anode and cathode was assembled to exhibit a low cell voltage of 1.85 V at a large current density of 500 mA cm-2 and an excellent long-term stability within 50 h, better than most of the state-of-the-art bifunctional electrocatalysts yet reported.	Water	20-25	neurofascin	Homo sapiens	60-62
34237589-0	2021	Residue interaction networks of K-Ras protein with water molecules identifies the potential role of switch II and P-loop.	Water	51-56	KRAS proto-oncogene, GTPase	Homo sapiens	32-37
34237589-2	2021	The proposed study investigated the influence of water molecules in K-Ras crystal structure, where they have a significant function by understanding their residue interaction networks (RINs).	Water	49-54	KRAS proto-oncogene, GTPase	Homo sapiens	68-73
27959882-3	2016	In this study, arsenic levels in 13/20 of well water samples and 1/7 of tap water samples exceeded World Health Organization (WHO) health-based guideline value for drinking water.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
34237589-5	2021	We found that the residues K42, I142, and L159 are the hotspots from water, including the K-Ras-GTP complex with the highest residue centrality analysis (RCA) Z-score.	Water	69-74	KRAS proto-oncogene, GTPase	Homo sapiens	90-95
34237589-8	2021	Taken together, our study helps in understanding the functional importance of the water molecules in K-Ras protein and the impact of mutation that modulate the conformational state of the protein.	Water	82-87	KRAS proto-oncogene, GTPase	Homo sapiens	101-106
34502490-7	2021	We conclude that Th17/Th1 cells are generated locally, are resistant to the immunosuppressive effects of steroids, and contribute to early development of EAU.	Water	154-157	negative elongation factor complex member C/D	Homo sapiens	22-25
27959882-3	2016	In this study, arsenic levels in 13/20 of well water samples and 1/7 of tap water samples exceeded World Health Organization (WHO) health-based guideline value for drinking water.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
34987131-8	2021	The water channel protein aquaporin-5 (AQP5) was expressed in the basal cytoplasmic regions of acini in young SMGs but showed a decreased expression in aged SMGs.	Water	4-9	aquaporin 5	Mus musculus	26-37
34987131-8	2021	The water channel protein aquaporin-5 (AQP5) was expressed in the basal cytoplasmic regions of acini in young SMGs but showed a decreased expression in aged SMGs.	Water	4-9	aquaporin 5	Mus musculus	39-43
34246954-7	2021	Moreover, treatment with the Japanese traditional herbal medicine, hangeshashinto (HST), decreased fecal water content and improved fecal appearance in rats treated with EGFR-TKIs.	Water	105-110	epidermal growth factor receptor	Rattus norvegicus	170-174
27005824-4	2016	Furthermore, the Bodipy-based sensor has obvious advantages including simplicity, rapid response, high selectivity, sensitivity and a detection limit of 1.2 mumol/L, and has been demonstrated in real water samples including tap water, mineral water and water from Lake Tai.	Water	200-205	nuclear RNA export factor 1	Homo sapiens	224-227
34410982-1	2021	BACKGROUND/AIM: To develop and validate an easy-to-use and cheap method capable of producing placebo from tap water for medicinal water efficacy trials.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	106-109
34410982-1	2021	BACKGROUND/AIM: To develop and validate an easy-to-use and cheap method capable of producing placebo from tap water for medicinal water efficacy trials.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	106-109
34410982-4	2021	Patients were asked four times during the bath to tell if they were treated with medicinal water, tap water, or could not decide.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
34410982-10	2021	CONCLUSION: The used method is appropriate for producing a validated placebo from tap water.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
34214747-17	2021	The number of IgA+ and CD8+ cells in lamina propria of intestine was decreased in chickens fed diet supplemented with Lacto-Immuno-Vital in drinking water.	Water	149-154	CD8a molecule	Gallus gallus	23-26
34089758-0	2021	The basicity of an active-site water molecule discriminates between tyrosinase and catechol oxidase activity.	Water	31-36	tyrosinase	Homo sapiens	68-78
27779666-1	2016	The aim of the present study was to determine the effects of the insulin-like growth factor 1 (IGF-1)/phosphatase and tensin homologue deleted on chromosome 10 (PTEN)/Akt/forkhead box (FoxO) signaling pathway on male reproduction in rats subjected to water immersion and restraint stress (WRS).	Water	251-256	phosphatase and tensin homolog	Rattus norvegicus	161-165
27830987-2	2016	AOX acts as a means to relax the highly coupled and tensed electron transport process in mitochondria thus providing and maintaining the much needed metabolic homeostasis by directly reducing oxygen to water.	Water	202-207	acyl-CoA oxidase 1	Homo sapiens	0-3
34452111-7	2021	These results suggest that the solubilization of high drug amounts and the controlled release of poorly water-soluble PTX using TNPs could significantly improve its anticancer therapy, particularly in the treatment of MDR-p-glycoprotein-overexpressing cancers.	Water	104-109	C1GALT1 specific chaperone 1	Homo sapiens	128-132
34393794-1	2021	Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use.	Water	108-113	apelin	Rattus norvegicus	0-6
34079063-0	2021	Spatial and temporal distribution of surface water contaminants in the Houston Ship Channel after the Intercontinental Terminal Company Fire.	Water	45-50	inositol polyphosphate-5-phosphatase D	Homo sapiens	79-83
27720326-8	2016	Further, a molecular model of the putative CCR5-MOR heterodimer was constructed, docked with the bivalent ligand, and molecular dynamics simulations of the complex was performed in a membrane-water system to help understand the biological observation.	Water	192-197	C-C motif chemokine receptor 5	Homo sapiens	43-47
34271453-1	2021	Storage containers are usually used to provide a constant water head in decentralized, community groundwater treatment systems for the removal of iron (Fe) and arsenic (As).	Water	58-63	general transcription factor IIE subunit 1	Homo sapiens	152-154
34212725-1	2021	Dissolution of uranium oxide was carried out using a solution of HD2EHP in C8mim NTf2, which was apparently facilitated by the in situ generation of water during the complex formation reaction.	Water	149-154	nuclear transport factor 2	Homo sapiens	81-85
27845441-6	2016	The CNF-backboned PB (CNF/PB) was found to be highly tolerant to water and moreover, it gave a 139 mg/g capability and a million (106) order of magnitude distribution coefficient (Kd) for absorbing of the radioactive cesium ion.	Water	65-70	NPHS1 adhesion molecule, nephrin	Homo sapiens	4-7
34336828-12	2021	Wild-type mice treated with CCl4 developed significant multi-organ injury (increased ALT, creatinine, and brain water) upon LPS injection, and showed increased hepatic GSDMD cleavage compared to mice treated with CCl4 alone.	Water	112-117	chemokine (C-C motif) ligand 4	Mus musculus	28-32
34266277-9	2021	In solution, this syn conformation transforms to the gauche form because the intramolecular HB is disrupted by explicit water molecules that form intermolecular HBs with the hydroxyl and carbonyl groups.	Water	120-125	synemin	Homo sapiens	18-21
34895791-0	2021	"The home, the bathroom, the taps, and hot water": The contextual characteristics of tap water scalds in Australia and New Zealand.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
34895791-1	2021	INTRODUCTION: Scalds from hot tap water can have devastating consequences and lifelong impact on survivors.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
34895791-2	2021	The aims of this study were to (i) describe the frequency, demographic profile, injury event characteristics, and in-hospital outcomes for people with tap water scalds admitted to Australian and New Zealand burn centres; and (ii) determine whether variation was present in the frequency and epidemiological characteristics of tap water scalds between jurisdictions.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	151-154
34895791-2	2021	The aims of this study were to (i) describe the frequency, demographic profile, injury event characteristics, and in-hospital outcomes for people with tap water scalds admitted to Australian and New Zealand burn centres; and (ii) determine whether variation was present in the frequency and epidemiological characteristics of tap water scalds between jurisdictions.	Water	330-335	nuclear RNA export factor 1	Homo sapiens	326-329
34895791-3	2021	METHODS: Data were extracted from the Burns Registry of Australia and New Zealand for people with tap water scalds admitted to Australian or New Zealand burn centres between January 1, 2010 and December 31, 2018.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
34895791-5	2021	RESULTS: We included 650 people with tap water scalds admitted to Australian and New Zealand burn centres during the study period.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
34895791-6	2021	Australians with tap water scalds (median (IQR) 29 (1-69) years) were older than New Zealanders (2 (1-36) years).	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
34895791-7	2021	Most tap water scalds occurred in the home, and 92% of these occurred in the bathroom.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	5-8
27845441-6	2016	The CNF-backboned PB (CNF/PB) was found to be highly tolerant to water and moreover, it gave a 139 mg/g capability and a million (106) order of magnitude distribution coefficient (Kd) for absorbing of the radioactive cesium ion.	Water	65-70	NPHS1 adhesion molecule, nephrin	Homo sapiens	22-28
34895791-8	2021	More than 55% of injuries occurred due to the accidental alteration of water temperature at the tap fixture.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	96-99
34895791-11	2021	CONCLUSION: Tap water scalds remain a public health problem in Australia and New Zealand.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
27976756-2	2016	We have used QCLMS to understand the final maturation step of the proteasome lid and also to elucidate the structure of complement C3(H2O).	Water	134-137	complement C3	Homo sapiens	120-133
34895791-12	2021	Our research highlights where gaps in current heated water regulations in residential homes perpetuate risks of tap water scalds, particularly in high-risk groups at the extremes of age.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	112-115
34895791-12	2021	Our research highlights where gaps in current heated water regulations in residential homes perpetuate risks of tap water scalds, particularly in high-risk groups at the extremes of age.	Water	116-121	nuclear RNA export factor 1	Homo sapiens	112-115
34246959-0	2021	Sample preparation optimization by central composite design for multi class determination of 172 emerging contaminants in wastewaters and tap water using liquid chromatography high-resolution mass spectrometry.	Water	142-147	nuclear RNA export factor 1	Homo sapiens	138-141
34246959-2	2021	To this end, a comprehensive workflow for the quantitative analysis of 172 anthropogenic organic compounds belonging to emerging contaminants (pharmaceuticals and personal care products, illicit drugs, organophosphate flame retardants and perfluoroalkyl substances) has been developed for application to wastewater and tap water, based on solid phase extraction (SPE) and Orbitrap high resolution mass spectrometry (HRMS).	Water	323-328	nuclear RNA export factor 1	Homo sapiens	319-322
34306741-15	2021	According to binary and multivariate logistic regression analyses, the parents without awareness, pupils with a nail-biting habit, pupils not wearing shoes during play, lack of deworming, drinking direct tap water, and pupils with poor hand sanitation were more likely to be infested with intestinal parasitic infections.	Water	208-213	nuclear RNA export factor 1	Homo sapiens	204-207
34080589-7	2021	The fluorescence imprinted sensor was applied to recognize ketoprofen in tap water, lake water, waste water and human urine samples rapidly with the recoveries of 97.3-103.7%.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
34564479-0	2021	Progress in Research and Application of Nanofiltration (NF) Technology for Brackish Water Treatment.	Water	84-89	neurofascin	Homo sapiens	40-54
27516248-0	2016	Surfactant mediated synthesis of poly(acrylic acid) grafted xanthan gum and its efficient role in adsorption of soluble inorganic mercury from water.	Water	143-148	OTU deubiquitinase with linear linkage specificity	Homo sapiens	68-71
34564479-0	2021	Progress in Research and Application of Nanofiltration (NF) Technology for Brackish Water Treatment.	Water	84-89	neurofascin	Homo sapiens	56-58
34564479-5	2021	Hereon, an overview of the progress in research on and application of NF technology for brackish water treatment is provided.	Water	97-102	neurofascin	Homo sapiens	70-72
34299400-10	2021	A purified fraction of the black tea water extract inhibited both kallikrein and activated FXII.	Water	37-42	kallikrein related peptidase 4	Homo sapiens	66-76
34299400-11	2021	The black tea water extracts inhibited factor XII-induced cell migration and inhibited the production of kallikrein on the endothelial cell line.	Water	14-19	kallikrein related peptidase 4	Homo sapiens	105-115
34299400-12	2021	We compared the inhibitory effects of the black tea water extract and twenty-three well-known anti-inflammatory medicinal herbs, in inhibiting both kallikrein and FXII.	Water	52-57	kallikrein related peptidase 4	Homo sapiens	148-158
34299400-14	2021	Taken together, the black tea water extract exerts its anti-inflammatory effects, in part, by inhibiting kallikrein and activated FXII, which are part of the plasma kallikrein-kinin system (KKS), and by decreasing BK production.	Water	30-35	kallikrein related peptidase 4	Homo sapiens	105-115
34299400-14	2021	Taken together, the black tea water extract exerts its anti-inflammatory effects, in part, by inhibiting kallikrein and activated FXII, which are part of the plasma kallikrein-kinin system (KKS), and by decreasing BK production.	Water	30-35	kallikrein related peptidase 4	Homo sapiens	165-175
34564479-6	2021	On the basis of expounding the features of brackish water, the factors affecting NF efficiency, including the feed water characteristics, operating conditions and NF membrane properties, are analyzed.	Water	52-57	neurofascin	Homo sapiens	81-83
34564479-6	2021	On the basis of expounding the features of brackish water, the factors affecting NF efficiency, including the feed water characteristics, operating conditions and NF membrane properties, are analyzed.	Water	115-120	neurofascin	Homo sapiens	81-83
30404370-1	2016	Fast on-site monitoring of foreign microalgae species carried by ship ballast water has drawn more and more attention.	Water	78-83	inositol polyphosphate-5-phosphatase D	Homo sapiens	65-69
34564479-11	2021	Lessons gained from this review are expected to promote the sustainable development of brackish water treatment with NF technology.	Water	96-101	neurofascin	Homo sapiens	117-119
34485929-5	2021	Comparisons of the crystal structure of Mt-CYP11B1 to those of Wt-CYP11B1 and CYP11B2 that were already reported show that the mutation reduced the innermost space putatively surrounding the C3 side of substrate 11-deoxycorticosterone (DOC) bound to Wt-CYP11B1, while the corresponding space in CYP11B2 is enlarged markedly and accessible to bulk water through a channel.	Water	347-352	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	43-50
34485929-5	2021	Comparisons of the crystal structure of Mt-CYP11B1 to those of Wt-CYP11B1 and CYP11B2 that were already reported show that the mutation reduced the innermost space putatively surrounding the C3 side of substrate 11-deoxycorticosterone (DOC) bound to Wt-CYP11B1, while the corresponding space in CYP11B2 is enlarged markedly and accessible to bulk water through a channel.	Water	347-352	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	66-73
34485929-5	2021	Comparisons of the crystal structure of Mt-CYP11B1 to those of Wt-CYP11B1 and CYP11B2 that were already reported show that the mutation reduced the innermost space putatively surrounding the C3 side of substrate 11-deoxycorticosterone (DOC) bound to Wt-CYP11B1, while the corresponding space in CYP11B2 is enlarged markedly and accessible to bulk water through a channel.	Water	347-352	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	253-260
34125122-4	2021	Here, we develop a nanocomposite aqueous ink, obtained by blending commercial PEDOT:PSS with water-based, stable and highly concentrated molybdenum disulfide (MoS2) nanosheets, obtained via liquid phase exfoliation (LPE), which is suitable as a HTL for solution processed NPL-based LEDs.	Water	93-98	N-acetylneuraminate pyruvate lyase	Homo sapiens	272-275
27350321-7	2016	A role of Nhe3b (but not Nhe2 or Nhe3a) in Na(+) uptake in soft water was also supported through gene expression analyses: expression of nhe3b increased throughout development in whole embryos/larvae in both groups and was significantly higher in those reared in soft water.	Water	64-69	putative sodium hydrogen exchanger 3b	Oncorhynchus mykiss	10-15
34230564-5	2021	Tap water had an average pH of 5.24 +- 1.63, ranging from 3.86 to 8.89, with the average concentrations of As and Pb of 0.77 microg/L and 0.004 microg/L, respectively.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
34230564-6	2021	The levels of both As and Pb in the hair, fingernails and urine of shallow groundwater-consuming residents were greater than those in the hair, fingernails and urine of tap water-consuming residents.	Water	173-178	nuclear RNA export factor 1	Homo sapiens	169-172
34578820-0	2021	Using a Community-Based Participatory Mixed Methods Research Approach to Develop, Evaluate, and Refine a Nutrition Intervention to Replace Sugary Drinks with Filtered Tap Water among Predominantly Central-American Immigrant Families with Infants and Toddlers: The Water Up @Home Pilot Evaluation Study.	Water	171-176	nuclear RNA export factor 1	Homo sapiens	167-170
34578820-0	2021	Using a Community-Based Participatory Mixed Methods Research Approach to Develop, Evaluate, and Refine a Nutrition Intervention to Replace Sugary Drinks with Filtered Tap Water among Predominantly Central-American Immigrant Families with Infants and Toddlers: The Water Up @Home Pilot Evaluation Study.	Water	264-269	nuclear RNA export factor 1	Homo sapiens	167-170
34578820-2	2021	This manuscript describes the explicit integration of mixed-methods in four stages of CBPR: (1) connecting and diagnosing, (2) prescribing-implementing, (3) evaluating, and (4) disseminating and refining an intervention that aimed to motivate Latino parents (predominantly Central American in the US) of infants and toddlers to replace sugary drinks with filtered tap water.	Water	368-373	nuclear RNA export factor 1	Homo sapiens	364-367
34159985-3	2021	Here, the self-consistent field theory of Scheutjens and Fleer (SF-SCF) in which a lattice refinement has been implemented, is used to scrutinize how various additives modify the self-assembled phase behaviour of monoolein (MO) and 1,2-dioleoyl-phosphatidylcholine (DOPC) lipids in water.	Water	282-287	KIT ligand	Homo sapiens	67-70
27350321-7	2016	A role of Nhe3b (but not Nhe2 or Nhe3a) in Na(+) uptake in soft water was also supported through gene expression analyses: expression of nhe3b increased throughout development in whole embryos/larvae in both groups and was significantly higher in those reared in soft water.	Water	64-69	putative sodium hydrogen exchanger 3b	Oncorhynchus mykiss	137-142
34210097-11	2021	The consumption of 20% fructose water by Wistar rats for eight weeks displayed a tremendous increment in body weight, fat mass, percentage fat, LDL, TG, TC, HMG-CoA reductase, leptin, and reduced the levels of HDL and adiponectin as well as adipocyte hypertrophy.	Water	32-37	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	218-229
34500553-1	2021	A highly water and thermally stable metal-organic framework (MOF) Zn2(Pydc)(Ata)2 (1, H2Pydc = 3,5-pyridinedicarboxylic acid; HAta = 3-amino-1,2,4-triazole) was synthesized on a large scale using inexpensive commercially available ligands for efficient separation of C2H2 from CH4 and CO2.	Water	9-14	solute carrier family 38 member 2	Homo sapiens	66-81
27665146-9	2016	RESULTS: Water significantly increased the modulus of NG1 and NG2 dispersed in solvent, while significantly decreased the stiffness of NG3.	Water	9-14	interleukin 19	Homo sapiens	54-57
27512893-1	2016	This study examines arsenic, copper, lead and manganese drinking water contamination at the domestic consumer"s kitchen tap in homes of New South Wales, Australia.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	120-123
34302157-0	2021	Controlled synthesis of P-Co3O4@NiCo-LDH/NF nanoarrays as binder-free electrodes for water splitting.	Water	85-90	neurofascin	Homo sapiens	41-43
34302157-6	2021	The experimental results and theoretical calculations demonstrate that the electrocatalytic activity of the P-Co3O4@NiCo-LDH-2/NF material is attributed to the faster electron transfer rate, exposure of more active sites, optimal water adsorption energy and better electrical conductivity.	Water	230-235	neurofascin	Homo sapiens	127-129
34167493-6	2021	RESULTS: According to the generated results, place of residence province-wise, household head"s education level and source of drinking water have negative effect (lower risk) on child mortality in Sri Lanka.	Water	135-140	sorcin	Homo sapiens	197-200
27512893-7	2016	Analysis of kitchen tap fittings demonstrates these are a primary source of drinking water lead contamination (n=9, mean - 63.4microg/L, median - 59.0microg/L).	Water	85-90	nuclear RNA export factor 1	Homo sapiens	20-23
34451775-4	2021	Additionally, they mitigate drought-induced reactive oxygen species (ROS) through the aggregation of osmolytes, which results in enhanced osmotic adaptation and crop water balance.	Water	166-171	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	161-165
27679873-6	2016	Significant correlations were observed between population density and Sigma5PCM in both air and water, with strongest correlations within a 25 and 40 km radius, respectively.	Water	96-101	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	70-76
34346213-5	2021	We observed that Ru-Se bonds form via the coordination of a selenoether ligand with (Ru(tpy)(biq)(H2O))Cl2 (tpy = 2,2":6",2""-terpyridine, biq = 2,2"-biquinoline) in the dark, while the Ru-Se bond reversibly dissociates under visible-light irradiation.	Water	98-101	endogenous retrovirus group W member 5	Homo sapiens	103-106
34143822-1	2021	To realize the accurate extraction of surface water in complex environment, this study takes Sri Lanka as the study area owing to the complex geography and various types of water bodies.	Water	46-51	sorcin	Homo sapiens	93-96
34143822-1	2021	To realize the accurate extraction of surface water in complex environment, this study takes Sri Lanka as the study area owing to the complex geography and various types of water bodies.	Water	173-178	sorcin	Homo sapiens	93-96
34086019-4	2021	By virtue of a novel combination of catalyst design, reaction kinetics, isotope labeling, and multiple spectroscopic techniques, the real catalytic site for the conversion of -NO2 to -NH2 is identified to be the water-hydroxyl transition metal complex, which could further react with NaBH4 to form a new triangular configuration metal complex of H3B-water-hydroxyl with dynamic features.	Water	212-217	H3 clustered histone 4	Homo sapiens	346-349
28032063-12	2016	Moreover, sensitivity analysis indicated that tap water consumption (Pspearman &gt;0.92) and washing activities (Pspearman&gt;0.95) had the greatest correlation on the cancer risk.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
34099547-4	2021	In this study, we found that CDCP1 knockout (KO) mice exhibited attenuated coronary and aortic vasculitis and decreased serum Candida albicans water-soluble fraction (CAWS)-specific IgM/IgG2a and IL-6 concentrations compared with wild-type mice in an established model of KD induced by CAWS administration.	Water	143-148	CUB domain containing protein 1	Mus musculus	29-34
34484273-12	2021	In PPIs, enzymes from the CYP450, TaABA8OH2, PAL, and GST families play important roles in water-deficit tolerance in connection with MYB13-1, MADS-box, and NAC transcription factors.	Water	91-96	X-linked Kx blood group	Homo sapiens	157-160
34492917-4	2021	Therefore, this work examined, for the first time, the effects of resting time and RS concentration on the performance of the biosensing system for toxicity of Cr6+ in water.	Water	168-173	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	160-163
34492931-1	2021	2-Methylisoborneol (2-MIB), a natural odorous substance, is widely distributed in water environment, but there is a paucity of information concerning its systemic toxicity.	Water	82-87	MIB E3 ubiquitin protein ligase 1	Danio rerio	22-25
27595487-6	2016	The matrix effect was minimal, and tap water used for calibrators and controls.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
34384513-6	2022	RESULTS: The consumption of tap water increased in the IG from baseline to T1 and then decreased again at T2, but this was similar in the CG (no statistically significant difference in the time trend between the IG and CG).	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
34384513-7	2022	Similar results were seen for tap water consumption in the mornings.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
34384513-8	2022	The proportion of children who only drank tap water on school mornings increased significantly from baseline to T1 in the IG compared to the CG (p=0.020).	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
34384513-10	2022	CONCLUSIONS: Not only the children in the IG but also those in the CG drank more tap water after 1 school year than at the beginning.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
34114536-0	2022	Examining Recent Trends in the Racial Disparity Gap in Tap Water Consumption: NHANES 2011-2018.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
34114536-1	2022	OBJECTIVE: As tap water distrust has grown in the US with greater levels among Black and Hispanic households, we aimed to examine recent trends in not drinking tap water including the period covering the US Flint Water Crisis and racial/ethnic disparities in these trends.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
34114536-1	2022	OBJECTIVE: As tap water distrust has grown in the US with greater levels among Black and Hispanic households, we aimed to examine recent trends in not drinking tap water including the period covering the US Flint Water Crisis and racial/ethnic disparities in these trends.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	160-163
34114536-1	2022	OBJECTIVE: As tap water distrust has grown in the US with greater levels among Black and Hispanic households, we aimed to examine recent trends in not drinking tap water including the period covering the US Flint Water Crisis and racial/ethnic disparities in these trends.	Water	164-169	nuclear RNA export factor 1	Homo sapiens	14-17
34114536-1	2022	OBJECTIVE: As tap water distrust has grown in the US with greater levels among Black and Hispanic households, we aimed to examine recent trends in not drinking tap water including the period covering the US Flint Water Crisis and racial/ethnic disparities in these trends.	Water	164-169	nuclear RNA export factor 1	Homo sapiens	160-163
34114536-6	2022	RESULTS: Among US children and adults, respectively, in 2017-2018 there was a 63% (adjusted prevalence ratio (PR):1.63, 95%CI: 1.25-2.12, p<0.001) and 40% (PR:1.40, 95%CI: 1.16-1.69, p=0.001) higher prevalence of not drinking tap water compared to 2013-2014 (pre-Flint Water Crisis).	Water	230-235	nuclear RNA export factor 1	Homo sapiens	226-229
34114536-7	2022	For Black children and adults, the probability of not drinking tap water increased significantly from 18.1% (95%CI: 13.4-22.8) and 24.6% (95%CI: 20.7-28.4) in 2013-14 to 29.3% (95%CI: 23.5-35.1) and 34.5% (95%CI: 29.4-39.6) in 2017-2018.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
34114536-8	2022	Among Hispanic children and adults, not drinking tap water increased significantly from 24.5% (95%CI: 19.4-29.6) and 27.1% (95%CI: 23.0-31.2) in 2013-14 to 39.7% (95%CI: 32.7-46.8) and 38.1% (95%CI: 33.0-43.1) in 2017-2018.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
34114536-11	2022	CONCLUSIONS: This study found persistent disparities in the tap water consumption gap from 2011-2018.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
27422225-11	2016	Higher levels of mRNA expression of COL IV, MMP9, and TGFbeta were verified in water bath-processed resin, which were similar to those in the nonstimulated group.	Water	79-84	matrix metallopeptidase 9	Homo sapiens	44-48
34349903-0	2021	(GaF(H2O))(IO3F): a promising NLO material obtained by anisotropic polycation substitution.	Water	5-8	fibroblast growth factor 9	Homo sapiens	1-4
27524292-0	2016	A study on the structural features of SELK, an over-expressed protein in hepatocellular carcinoma, by molecular dynamics simulations in a lipid-water system.	Water	144-149	selenoprotein K	Homo sapiens	38-42
34349903-1	2021	A novel salt-inclusion fluoroiodate (GaF(H2O))(IO3F) derived from CsIO2F2 was ingeniously obtained through anisotropic polycation substitution.	Water	41-44	fibroblast growth factor 9	Homo sapiens	37-40
34349903-2	2021	Because the catenulate (GaF(H2O))2+ framework serves as a template for the favorable assembly of the polar (IO3F)2- groups and contributes to the nonlinear coefficient, (GaF(H2O))(IO3F) exhibits a greatly improved second-harmonic generation (SHG) effect of 10 times that of KH2PO4 (KDP) and a considerable band gap of 4.34 eV compared to the parent compound CsIO2F2 (3 x KDP, 4.5 eV).	Water	28-31	fibroblast growth factor 9	Homo sapiens	24-27
34349903-2	2021	Because the catenulate (GaF(H2O))2+ framework serves as a template for the favorable assembly of the polar (IO3F)2- groups and contributes to the nonlinear coefficient, (GaF(H2O))(IO3F) exhibits a greatly improved second-harmonic generation (SHG) effect of 10 times that of KH2PO4 (KDP) and a considerable band gap of 4.34 eV compared to the parent compound CsIO2F2 (3 x KDP, 4.5 eV).	Water	28-31	fibroblast growth factor 9	Homo sapiens	170-173
34349903-2	2021	Because the catenulate (GaF(H2O))2+ framework serves as a template for the favorable assembly of the polar (IO3F)2- groups and contributes to the nonlinear coefficient, (GaF(H2O))(IO3F) exhibits a greatly improved second-harmonic generation (SHG) effect of 10 times that of KH2PO4 (KDP) and a considerable band gap of 4.34 eV compared to the parent compound CsIO2F2 (3 x KDP, 4.5 eV).	Water	174-177	fibroblast growth factor 9	Homo sapiens	24-27
34349903-2	2021	Because the catenulate (GaF(H2O))2+ framework serves as a template for the favorable assembly of the polar (IO3F)2- groups and contributes to the nonlinear coefficient, (GaF(H2O))(IO3F) exhibits a greatly improved second-harmonic generation (SHG) effect of 10 times that of KH2PO4 (KDP) and a considerable band gap of 4.34 eV compared to the parent compound CsIO2F2 (3 x KDP, 4.5 eV).	Water	174-177	fibroblast growth factor 9	Homo sapiens	170-173
34349903-3	2021	Particularly, to the best of our knowledge, (GaF(H2O))(IO3F) has the largest laser-induced damage threshold (LDT) of 140 x AgGgS2 of the reported iodates.	Water	49-52	fibroblast growth factor 9	Homo sapiens	45-48
34349903-4	2021	All these results signify that (GaF(H2O))(IO3F) is a promising nonlinear optical (NLO) crystal.	Water	36-39	fibroblast growth factor 9	Homo sapiens	32-35
34445343-4	2021	The majority of NMOSD patients are seropositive for IgG autoantibodies against the water channel protein aquaporin-4 (AQP4-IgG), reflecting underlying aquaporin-4 autoimmunity.	Water	83-88	aquaporin 4	Homo sapiens	105-116
34445343-4	2021	The majority of NMOSD patients are seropositive for IgG autoantibodies against the water channel protein aquaporin-4 (AQP4-IgG), reflecting underlying aquaporin-4 autoimmunity.	Water	83-88	aquaporin 4	Homo sapiens	118-122
34232129-0	2021	Inhibition of CAMK II modulates water permeability by reducing AQP4 expression in astrocytes after oxygen-glucose deprivation.	Water	32-37	aquaporin 4	Homo sapiens	63-67
34232129-4	2021	Aquaporin-4 (AQP4), which is expressed primarily in the brain, is a water-transport protein.	Water	68-73	aquaporin 4	Homo sapiens	0-11
27524292-5	2016	To study the structural features of SELK in the membrane, we have modeled the protein and then subjected it to molecular dynamics simulations in a lipid-water system.	Water	153-158	selenoprotein K	Homo sapiens	36-40
34232129-4	2021	Aquaporin-4 (AQP4), which is expressed primarily in the brain, is a water-transport protein.	Water	68-73	aquaporin 4	Homo sapiens	13-17
34201160-2	2021	We examined the association between urinary fluoride adjusted for specific gravity (UFSG) and tap water fluoride levels, by age and sex, among individuals living in Canada.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
27680745-3	2016	The as-prepared Au NCs are water soluble and highly fluorescent and exhibit high sensitivity and selectivity for Hg2+ detection in aqueous solution.	Water	27-32	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	113-116
34201232-6	2021	Furthermore, the optimization of the process conditions made it possible to print pieces of complex geometry and permeable parts for the control of the water flow rates with an order of magnitude in the range from mL/h to mL/day.	Water	152-157	thrombopoietin	Mus musculus	214-216
34201232-6	2021	Furthermore, the optimization of the process conditions made it possible to print pieces of complex geometry and permeable parts for the control of the water flow rates with an order of magnitude in the range from mL/h to mL/day.	Water	152-157	thrombopoietin	Mus musculus	222-224
34443406-7	2021	Zwitterionic and TSK gel amide and amine columns show especially strong water adsorption.	Water	72-77	tsukushi, small leucine rich proteoglycan	Homo sapiens	17-20
27782415-2	2016	The method is first validated for ST2 water, for which the so far strongest evidence for a liquid-liquid phase transition exists.	Water	38-43	ST2	Homo sapiens	34-37
34420328-6	2021	We illustrate our idea-which is inspired by the so-called Mpemba effect, i.e., water freezing faster when initially heated up-by showing how to achieve an exponential speeding-up in the convergence to stationarity in Dicke models, and how to avoid metastable regimes in an all-to-all interacting spin system.	Water	79-84	spindlin 1	Homo sapiens	296-300
34199635-7	2021	Here, the hydrophilicity and the GRP receptor binding affinities were found to be especially strongly influenced by the number of negative charges and peptide copies, showing logD (1-octanol-water-distribution coefficient) and IC50 (half maximal inhibitory concentration) values of -2.2 +- 0.1 and 59.1 +- 1.5 nM for the homodimer, and -1.9 +- 0.1 and 99.8 +- 3.2 nM for the homotetramer, respectively.	Water	191-196	gastrin releasing peptide	Homo sapiens	33-36
34136483-6	2021	The Lcn2 protein levels, percentage of TUNEL-positive cells, and GFAP-positive area were significantly higher in retinae cultured under 50 cm H2O pressure loads compared to those cultured under 20 cm H2O.	Water	142-145	lipocalin 2	Homo sapiens	4-8
34136483-6	2021	The Lcn2 protein levels, percentage of TUNEL-positive cells, and GFAP-positive area were significantly higher in retinae cultured under 50 cm H2O pressure loads compared to those cultured under 20 cm H2O.	Water	142-145	glial fibrillary acidic protein	Homo sapiens	65-69
34385833-16	2021	Water extracts also increased percentage viability of treated cells and levels of anti-inflammatory IL-10 non-significantly.	Water	0-5	interleukin 10	Homo sapiens	100-105
27729739-12	2016	In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure.	Water	35-40	aquaporin 4 L homeolog	Xenopus laevis	30-34
34072656-4	2021	Tap water supplemented with nutrients was fed to the two modules to enhance biofilm formation.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
27312615-2	2016	MDG-1, a water-soluble beta-d-fructan polysaccharide from Ophiopogon japonicas has potent hypolipidemic and weight-control effects.	Water	9-14	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	0-5
34241176-7	2021	The structural evolution of (NaSCN)2(H2O)n -/0 (n = 0-7) confirms the possible existence of ionic clusters such as Na(SCN)2 - and Na2(SCN)+ in NaSCN aqueous solutions.	Water	37-40	growth factor independent 1 transcriptional repressor	Homo sapiens	115-123
34315942-3	2021	One-dimensional oedometer swell tests were conducted using distilled water, tap water, and municipal landfill leachate, resulting in the determination of the expansion indices.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
34443738-10	2021	The present unique results provide useful information for synthesis of bean sprout-like Co-TiO2/Ti hybrid nanostructures and their applications to CO2 reduction and electrochemical water splitting in energy and environmental fields.	Water	181-186	brain expressed associated with NEDD4 1	Homo sapiens	71-75
25974044-0	2016	Reply to why use tap water by Nagoba et al.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
34372036-9	2021	The hot-pressing process improves the resistance of the MNP@CBPs to the penetration of water/non-aqueous liquids.	Water	87-92	sushi repeat containing protein X-linked 2	Homo sapiens	60-64
34073651-7	2021	In addition, the accumulation of powdered activated carbon in O3-BAC pre-treated water on the membrane surface could be the key reason protecting the NF membrane from fouling.	Water	81-86	neurofascin	Homo sapiens	150-152
26399223-0	2016	Cleansing of wounds by tap water?	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
34063758-3	2021	Furthermore, the fluorescent probe L could be utilized for detection in real water samples with satisfactory recoveries in the range 99.20%~104.30% in lake water and 100.00%~104.80% in tap water by UV-Vis absorption spectrometry, and in the range 100.50%~108.60% in lake water and 102.70%~103.80% in tap water by fluorescence spectrophotometry.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	185-188
34063758-3	2021	Furthermore, the fluorescent probe L could be utilized for detection in real water samples with satisfactory recoveries in the range 99.20%~104.30% in lake water and 100.00%~104.80% in tap water by UV-Vis absorption spectrometry, and in the range 100.50%~108.60% in lake water and 102.70%~103.80% in tap water by fluorescence spectrophotometry.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	300-303
34063758-3	2021	Furthermore, the fluorescent probe L could be utilized for detection in real water samples with satisfactory recoveries in the range 99.20%~104.30% in lake water and 100.00%~104.80% in tap water by UV-Vis absorption spectrometry, and in the range 100.50%~108.60% in lake water and 102.70%~103.80% in tap water by fluorescence spectrophotometry.	Water	189-194	nuclear RNA export factor 1	Homo sapiens	185-188
34063758-3	2021	Furthermore, the fluorescent probe L could be utilized for detection in real water samples with satisfactory recoveries in the range 99.20%~104.30% in lake water and 100.00%~104.80% in tap water by UV-Vis absorption spectrometry, and in the range 100.50%~108.60% in lake water and 102.70%~103.80% in tap water by fluorescence spectrophotometry.	Water	304-309	nuclear RNA export factor 1	Homo sapiens	300-303
34176270-0	2021	Antiferromagnetic Order and Spin-Canting Transition in the Corrugated Square Net Compound Cu3(TeO4)(SO4) H2O.	Water	105-108	spindlin 1	Homo sapiens	28-32
34176270-11	2021	We present Cu3(TeO4)(SO4) H2O as a promising platform for the future doping and strain experiments that could tune the Mott insulating ground state into superconducting or spin liquid states.	Water	26-29	spindlin 1	Homo sapiens	172-176
27460145-3	2016	We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates alpha3, alpha4, alpha5, alpha6, alpha7, beta2, and beta4 nAChR subunits from human and rat cortical extracts, and rat midbrain and olfactory bulb extracts, suggesting that Lynx1 forms complexes with multiple nAChR subtypes in the human and rodent brain.	Water	53-58	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	167-172
34299111-3	2021	Astrocytic endfeet and their dense expression of the aquaporin-4 water channels promote fluid exchange between the perivascular spaces and the neuropil.	Water	65-70	aquaporin 4	Homo sapiens	53-64
34093583-5	2021	Systemic suppression of SIRPalpha+ DCs in animals deficient in CD47 resulted in the inability of autoreactive CD4+ T cells to develop, which is crucial to induction of EAU.	Water	168-171	CD47 molecule	Homo sapiens	63-67
34093583-7	2021	These results identify CD47 as a significant regulator in the development of SIRPalpha+ DCs that is vital to disease induction in EAU.	Water	130-133	CD47 molecule	Homo sapiens	23-27
27440550-5	2016	Competitive growth analysis under water-limited conditions showed that OsRSP3 promoter-driven TaNAC69-1 transgenic lines produced 32% and 35% more above-ground biomass and grains than wild-type plants, respectively.	Water	34-39	NAC transcription factor 29	Triticum aestivum	94-103
34136673-0	2021	Determination and health risk assessment of trace elements in the tap water of two Sub-Cities of Addis Ababa, Ethiopia.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
34136673-7	2021	Conversely, tap water from Akaki-Kality contained significantly higher levels of As than that from Gullele.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
34305569-2	2021	The complicated network of the GS consists of the periarterial CSF influx pathway, astrocytes-mediated convective transport of fluid and solutes supported by AQP4 water channels, and perivenous efflux pathway.	Water	163-168	aquaporin 4	Homo sapiens	158-162
27419667-4	2016	This structural comparison revealed that the conformation of TN1-Fab does not substantially change after hTPO binding and a set of 15 water molecules is released from the antigen-binding site (paratope) of TN1-Fab upon hTPO complexation.	Water	134-139	thyroid peroxidase	Homo sapiens	219-223
34241395-2	2021	Using microwave dielectric spectroscopy, we have assessed the amount of water associated with hydration shells of methemoglobin as a function of its concentration in the presence or absence of ions.	Water	72-77	hemoglobin subunit gamma 2	Homo sapiens	114-127
34241395-4	2021	Within the concentration range of 5-10 g/dl of methemoglobin, ions play an important role in defining the free-to-bound water ratio competing with hemoglobin to recruit water molecules for the hydration shell.	Water	120-125	hemoglobin subunit gamma 2	Homo sapiens	47-60
34241395-4	2021	Within the concentration range of 5-10 g/dl of methemoglobin, ions play an important role in defining the free-to-bound water ratio competing with hemoglobin to recruit water molecules for the hydration shell.	Water	169-174	hemoglobin subunit gamma 2	Homo sapiens	47-60
34241395-7	2021	The theoretical evaluation of the ratio of free and bound water for the hemoglobin concentration in the absence of ions corresponds with the experimental results and shows that the methemoglobin molecule binds about 1400 water molecules.	Water	58-63	hemoglobin subunit gamma 2	Homo sapiens	181-194
34241395-7	2021	The theoretical evaluation of the ratio of free and bound water for the hemoglobin concentration in the absence of ions corresponds with the experimental results and shows that the methemoglobin molecule binds about 1400 water molecules.	Water	221-226	hemoglobin subunit gamma 2	Homo sapiens	181-194
34467318-0	2021	Water Splitting with a Single-Atom Cu/TiO2 Photocatalyst: Atomistic Origin of High Efficiency and Proposed Enhancement by Spin Selection.	Water	0-5	spindlin 1	Homo sapiens	122-126
34467318-9	2021	The spin selection mechanism does not require formation of the H species, which necessitates concurrent sources of electrons and protons and which is intrinsically unstable because water splitting involves frequent proton shuffling.	Water	181-186	spindlin 1	Homo sapiens	4-8
34853267-8	2021	Compared with the WT mice, ABCA1 KO mice stayed for a shorter time in the closed arm of the elevated plus maze, and performed worse in the initial stage of the Morris water maze.	Water	167-172	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	27-32
27281037-5	2016	After 12 months of water-ageing, NACP-QADM-NAg had a flexural strength and elastic modulus matching those of the commercial control (P&gt;0.1).	Water	19-24	NBAS subunit of NRZ tethering complex	Homo sapiens	43-46
35525019-5	2022	Low field nuclear magnetic resonance showed that T21 and T22 of SF3 sample were shorter than SF1 and SF2 samples (P < 0.05), implying that SF3 reduced the mobility of mobile water and free water.	Water	174-179	splicing factor 1	Homo sapiens	93-96
32263499-3	2016	Upon counter-anion exchange of PIL(Br) chains using lithium bis(trifluoromethanesulfonyl) amide (LiTf2N) to yield PIL(Tf2N), the wettability of the surface changes from hydrophilic (water contact angle ~52 ) to hydrophobic (~97 ).	Water	182-187	serpin family A member 2 (gene/pseudogene)	Homo sapiens	31-34
35168045-0	2022	Galla rhois water extract inhibits enzymatic browning in apple juice partly by binding to and inactivating polyphenol oxidase.	Water	12-17	polyphenol oxidase, chloroplastic	Malus domestica	107-125
34109953-5	2021	The electrolytic cell displayed a low cell voltage of 1.50 V when the Co-N-Ni3S2/NF material was used as the bifunctional water splitting electrocatalyst, which is one of the best catalysts reported so far.	Water	122-127	neurofascin	Homo sapiens	75-83
34109953-6	2021	Density functional theory calculations show that Co-N-Ni3S2/NF exhibits stronger water adsorption energy than those of N-Ni3S2/NF, Co-Ni3S2/NF and Ni3S2/NF.	Water	81-86	neurofascin	Homo sapiens	54-62
32263499-3	2016	Upon counter-anion exchange of PIL(Br) chains using lithium bis(trifluoromethanesulfonyl) amide (LiTf2N) to yield PIL(Tf2N), the wettability of the surface changes from hydrophilic (water contact angle ~52 ) to hydrophobic (~97 ).	Water	182-187	serpin family A member 2 (gene/pseudogene)	Homo sapiens	114-117
35490954-0	2022	A water-soluble fluorescent probe for real-time visualization of gamma-glutamyl transpeptidase activity in living cells.	Water	2-7	inactive glutathione hydrolase 2	Homo sapiens	65-94
27578405-1	2016	The application of magnetized graphene (G) layers synthesized on the carbon nanofibers (CNFs) (m-G/CNF) was investigated as novel adsorbent for the magnetic solid-phase extraction (MSPE) of polycyclic aromatic hydrocarbons (PAHs) in water samples followed by gas chromatography-flame ionization detector (GC-FID).	Water	233-238	NPHS1 adhesion molecule, nephrin	Homo sapiens	88-91
35306063-2	2022	These ligands control the reactivity, mobility, solubility and speciation of Fe, which have a potential impact on Fe bioavailability and cloud water oxidant capacity.	Water	143-148	general transcription factor IIE subunit 1	Homo sapiens	77-79
35306063-3	2022	In this work, the concentrations of Fe-binding ligands and the conditional stability constants were experimentally measured for the first time by Competitive Ligand Exchange-Adsorptive Cathodic Stripping Voltammetry (CLE-ACSV) technique in cloud water samples collected at puy de Dome (France).	Water	246-251	general transcription factor IIE subunit 1	Homo sapiens	36-38
35306063-5	2022	To understand the effect of Fe complexation on cloud water reactivity, we used the CLEPS cloud chemistry model.	Water	53-58	general transcription factor IIE subunit 1	Homo sapiens	28-30
34205326-7	2021	Eighteen radiation-induced genes and sixteen non-radiation-induced gene players have been identified from the ATR/ATM protein interaction complexes involved in heat, salt, water, osmotic stress responses, and plant organogenesis.	Water	172-177	Serine/Threonine-kinase ATM-like protein	Arabidopsis thaliana	114-117
34085828-5	2021	In the TaO2+ reaction with one H2O molecule, both the hydrated adduct H2O-TaO2+ and dihydroxide TaO(OH)2+ are generated.	Water	31-34	TAO kinase 2	Homo sapiens	74-78
34085828-5	2021	In the TaO2+ reaction with one H2O molecule, both the hydrated adduct H2O-TaO2+ and dihydroxide TaO(OH)2+ are generated.	Water	70-73	TAO kinase 2	Homo sapiens	7-11
34085828-5	2021	In the TaO2+ reaction with one H2O molecule, both the hydrated adduct H2O-TaO2+ and dihydroxide TaO(OH)2+ are generated.	Water	70-73	TAO kinase 2	Homo sapiens	74-78
34085828-7	2021	However, only the hydrated H2O-Ta(OH)4+ product is obtained in the TaO2 reaction with three H2O molecules.	Water	27-30	TAO kinase 2	Homo sapiens	67-71
27546061-9	2016	Electron-nuclear double resonance spectroscopy data exclude histidine or water as axial ligands for ferric DGCR8 and favor bis-thiolate coordination in this form.	Water	73-78	DGCR8 microprocessor complex subunit	Homo sapiens	107-112
34085828-7	2021	However, only the hydrated H2O-Ta(OH)4+ product is obtained in the TaO2 reaction with three H2O molecules.	Water	92-95	TAO kinase 2	Homo sapiens	67-71
35508254-2	2022	Herein, we have verified anticancer effectivity of synthesized novel water soluble mononuclear dipicolinic acid-1-allyl imidazole-based oxidovanadium (IV) complex (VOL(1-allylimz)2) with respect to anticancer effectivity of known standard platinum-based anticancer agent cisplatin.	Water	69-74	mediator complex subunit 25	Homo sapiens	107-113
34078074-0	2021	Heterostructured Ni3S2-Ni3P/NF as a Bifunctional Catalyst for Overall Urea-Water Electrolysis for Hydrogen Generation.	Water	75-80	neurofascin	Homo sapiens	28-30
27533739-4	2016	The origin of the enhanced activity was attributed to the spatially separated reactive sites for the evolution of H2 and O2 and also to the unidirectional migration of the electron and hole on the Janus surfaces, thereby preventing the unwanted reverse reaction of water splitting and decreasing charge recombination.	Water	265-270	relaxin 2	Homo sapiens	114-123
34086019-4	2021	By virtue of a novel combination of catalyst design, reaction kinetics, isotope labeling, and multiple spectroscopic techniques, the real catalytic site for the conversion of -NO2 to -NH2 is identified to be the water-hydroxyl transition metal complex, which could further react with NaBH4 to form a new triangular configuration metal complex of H3B-water-hydroxyl with dynamic features.	Water	350-355	H3 clustered histone 4	Homo sapiens	346-349
34203636-6	2021	METHODS: BLG was lactosylated at pH 7, a water activity (aw) of 0.43, and a temperature of 65  C using a molar ratio BLG:lactose of 1:1 by incubating for 0, 3, 8, 16 or 24 h. For the determination of the effect on antibody-binding capacity of lactosylated BLG, an ELISA was performed.	Water	41-46	beta-lactoglobulin	Bos taurus	9-12
35219194-0	2022	Self-supported Co9S8-Ni3S2-CNTs/NF electrode with superwetting multistage micro-nano structure for efficient bifunctional overall water splitting.	Water	130-135	neurofascin	Homo sapiens	32-34
35219194-5	2022	In addition, the production of hydrogen in an electrolytic water device with Co9S8-Ni3S2-CNTs/NF as bifunctional electrode prowered by the electricity derived from solar and wind energy in laboratory condition was artificially simulated.	Water	59-64	neurofascin	Homo sapiens	94-96
35189224-1	2022	Microplastics (MPs) could be as a vector to colonize microorganisms and antibiotic resistance gene (ARGs) in surface water.	Water	117-122	serpin family A member 2 (gene/pseudogene)	Homo sapiens	100-104
35189224-11	2022	The UV disinfection efficiency of microorganisms and ARGs was also intervened by PSMPs since they provided colonization sites and increased the water turbidity.	Water	144-149	serpin family A member 2 (gene/pseudogene)	Homo sapiens	53-57
27465126-4	2016	In one trial, tap water (4 ml/kg/15 min) was consumed (Plac trial).	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
35181365-5	2022	The drone water sampling method used here is the first to collect a sufficiently large volume of water to meet the monitoring requirements of large scale water monitoring programmes, 2 l, at a 100% success rate and most crucially, with water chemistry variables that are not significantly different to those taken using traditional boat water sampling.	Water	97-102	ataxin 1 like	Homo sapiens	332-336
34514925-0	2021	In-gel SOD assay reveals SOD-2 is the single active, water-soluble SOD enzyme in C. elegans.	Water	53-58	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	7-10
25605447-6	2016	In models stratified by tap water As, aggregate intake was a significant positive predictor of serum MMP-9 in subjects exposed to water As&lt;=10 mug/l.	Water	130-135	matrix metallopeptidase 9	Homo sapiens	101-106
34514925-0	2021	In-gel SOD assay reveals SOD-2 is the single active, water-soluble SOD enzyme in C. elegans.	Water	53-58	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	25-30
34514925-5	2021	Here we provide evidence that out of the five SOD proteins only the mitochondrial SOD is active in the water soluble fraction of C. elegans extracts albeit at an apparently much lower activity than the multiple active SODs in D. melanogaster and E. coli.	Water	103-108	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	46-49
34073651-1	2021	Nanofiltration (NF) is a promising post-treatment technology for providing high-quality drinking water.	Water	97-102	neurofascin	Homo sapiens	16-18
35305520-5	2022	Furthermore, the proposed "Turn-off" sensor could be employed to quickly and accurately quantify TCs residues even in milk, honey and tap water.	Water	138-143	nuclear RNA export factor 1	Homo sapiens	134-137
25605447-7	2016	Inorganic As from food alone was associated with serum MMP-9 in subjects exposed to tap water As&lt;=3 mug/l.	Water	88-93	matrix metallopeptidase 9	Homo sapiens	55-60
34073651-2	2021	However, membrane fouling remains a challenge to long-term NF in providing high-quality drinking water.	Water	97-102	neurofascin	Homo sapiens	59-61
34073651-3	2021	Herein, we found that coupling pre-treatments (sand filtration (SF) and ozone-biological activated carbon (O3-BAC)) and NF is a potent tactic against membrane fouling while achieving high-quality drinking water.	Water	205-210	neurofascin	Homo sapiens	120-122
35202467-2	2022	NMO patients harbor autoantibodies against the astrocytic water channel protein, aquaporin-4 (AQP4-IgG), which induce complement-mediated astrocyte lysis and subsequent axon damage.	Water	58-63	aquaporin 4	Homo sapiens	81-92
25605447-7	2016	Inorganic As from food alone was associated with serum MMP-9 in subjects exposed to tap water As&lt;=3 mug/l.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
35202467-2	2022	NMO patients harbor autoantibodies against the astrocytic water channel protein, aquaporin-4 (AQP4-IgG), which induce complement-mediated astrocyte lysis and subsequent axon damage.	Water	58-63	aquaporin 4	Homo sapiens	94-98
34073651-4	2021	The pilot results showed that using SF+O3-BAC pre-treated water as the feed water resulted in a lower but a slowly rising transmembrane pressure (TMP) in NF post-treatment, whereas an opposite observation was found when using SF pre-treated water as the feed water.	Water	58-63	neurofascin	Homo sapiens	154-156
34073651-4	2021	The pilot results showed that using SF+O3-BAC pre-treated water as the feed water resulted in a lower but a slowly rising transmembrane pressure (TMP) in NF post-treatment, whereas an opposite observation was found when using SF pre-treated water as the feed water.	Water	76-81	neurofascin	Homo sapiens	154-156
25605447-8	2016	Exposure to iAs from food and water combined, in areas where tap water As concentration is &lt;=10 mug/l, may contribute to As-induced changes in a biomarker associated with toxicity.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	61-64
25605447-8	2016	Exposure to iAs from food and water combined, in areas where tap water As concentration is &lt;=10 mug/l, may contribute to As-induced changes in a biomarker associated with toxicity.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
35378111-7	2022	Water-receiving animals had less c-Fos expression in the anterior basolateral amygdala than others groups.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	33-38
26531802-6	2016	Estimated maximum exposures reached 9 mug/kg/day among exclusively formula-fed infants in households with high tap water arsenic (80 mug/l).	Water	115-120	nuclear RNA export factor 1	Homo sapiens	111-114
34073869-1	2021	Reverse osmosis (RO) drinking water stations have been introduced to provide safe drinking water for areas with prevailing chronic kidney disease with unknown (CKDu) etiology in the dry zone of Sri Lanka.	Water	30-35	sorcin	Homo sapiens	194-197
28123825-3	2016	Aquaporin 4 (AQP4), is the most abundant water channel in CNS.	Water	41-46	aquaporin 4	Homo sapiens	0-11
34075536-7	2021	Ang(1-7) attenuated Abeta-induced increase in escape latency and decrease in the time spent in the target quadrant during Morris water maze and percentage of spontaneous alteration behavior during Y-maze tests in the rats.	Water	129-134	angiogenin	Rattus norvegicus	0-7
34075536-7	2021	Ang(1-7) attenuated Abeta-induced increase in escape latency and decrease in the time spent in the target quadrant during Morris water maze and percentage of spontaneous alteration behavior during Y-maze tests in the rats.	Water	129-134	amyloid beta precursor protein	Rattus norvegicus	20-25
35081754-0	2022	Factors Related to Water Filter Use for Drinking Tap Water at Home and Its Association with Consuming Plain Water and Sugar-Sweetened Beverages among U.S.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	49-52
35081754-0	2022	Factors Related to Water Filter Use for Drinking Tap Water at Home and Its Association with Consuming Plain Water and Sugar-Sweetened Beverages among U.S.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
35081754-0	2022	Factors Related to Water Filter Use for Drinking Tap Water at Home and Its Association with Consuming Plain Water and Sugar-Sweetened Beverages among U.S.	Water	108-113	nuclear RNA export factor 1	Homo sapiens	49-52
35081754-2	2022	OBJECTIVE: To examine factors associated with water filter use (WFU) for drinking tap water at home and its association with consuming plain water and sugar-sweetened beverages (SSBs).	Water	46-51	nuclear RNA export factor 1	Homo sapiens	82-85
35081754-2	2022	OBJECTIVE: To examine factors associated with water filter use (WFU) for drinking tap water at home and its association with consuming plain water and sugar-sweetened beverages (SSBs).	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
35081754-2	2022	OBJECTIVE: To examine factors associated with water filter use (WFU) for drinking tap water at home and its association with consuming plain water and sugar-sweetened beverages (SSBs).	Water	141-146	nuclear RNA export factor 1	Homo sapiens	82-85
34092951-4	2021	Further, the combined S and Se application (S + Se) significantly enhanced relative water content (16%), SPAD value (72%), photosynthetic rate (80%) and activities of catalase (79%), guaiacol peroxidase (53%) and superoxide dismutase (58%) in the leaves of water-stressed mung bean plants.	Water	257-262	catalase	Vigna radiata	167-175
28123825-3	2016	Aquaporin 4 (AQP4), is the most abundant water channel in CNS.	Water	41-46	aquaporin 4	Homo sapiens	13-17
27391339-7	2016	Similarly, inducible SHMT2 inhibition, via doxycycline-added drinking water, was found to reduce tumor incidence and tumor growth in a human tumor xenograft mouse model.	Water	70-75	serine hydroxymethyltransferase 2	Homo sapiens	21-26
34084909-0	2021	UBXN1 is a strong candidate gene in regulation of pork water-holding capacity.	Water	55-60	UBX domain protein 1	Sus scrofa	0-5
34084909-1	2021	The UBX domain containing protein 1-like gene (UBXN1) promotes the degradation of myofibrillar proteins during meat maturation, which affects meat water-holding capacity (WHC).	Water	147-152	UBX domain protein 1	Sus scrofa	47-52
35595294-0	2022	Guard-cell Targeted Overexpression of Arabidopsis Hexokinase 1 May Improve Water Use Efficiency in Field-Grown Tobacco Plants.	Water	75-80	hexokinase 1	Arabidopsis thaliana	50-62
35627541-0	2022	A Participatory Science Approach to Evaluating Factors Associated with the Occurrence of Metals and PFAS in Guatemala City Tap Water.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
35627541-2	2022	To address this need, 113 participants among households served by a range of water providers across the Guatemala City metropolitan area were recruited as participatory scientists to collect first-draw and flushed tap water samples at their residence.	Water	218-223	nuclear RNA export factor 1	Homo sapiens	214-217
27128204-4	2016	Using laser ablation in water, the solution of Fe species is dropped on Au-S-CD, where mass peaks at 1227 m/z, 1243 m/z, and 1260 m/z are observed and assigned to C42 H68 O34 SNa-Fe(+) , C42 H68 O34 SK-Fe(+) together with C42 H68 O34 SNa-FeO(+) , and C42 H68 O34 SK-FeO(+) , respectively.	Water	24-29	CDK5 regulatory subunit associated protein 1	Homo sapiens	163-166
35627541-9	2022	Overall, the high prevalence of arsenic above the MPL in Guatemala City tap water represents a potential health risk that current water treatment processes are not optimized to remove.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
35632077-1	2022	Water-lubricated stern bearing (WSB) is a vital part of the ship propulsion-shaft system, and it is of great significance to monitor and analyze its lubrication status through film thickness data to improve the equipment operational reliability.	Water	0-5	inositol polyphosphate-5-phosphatase D	Homo sapiens	60-64
35563573-9	2022	PsbS was shown as a component of primary importance in suiting plant response to FL under optimum and reduced water availability.	Water	110-115	Chlorophyll A-B binding family protein	Arabidopsis thaliana	0-4
35540800-1	2022	Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of guanidinoacetic acid (GAA) when used as nutritional additive in feed and water for drinking for all animal species.	Water	274-279	alpha glucosidase	Sus scrofa	223-226
35102375-9	2022	Adults who avoided their tap water consumed less tap and plain water, and significantly more bottled water and SSBs on a given day.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	25-28
35102375-10	2022	No tap intake and categories of tap water intake produced 77% and 78% areas under the ROC curve in predicting tap water avoidance.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	110-113
35102375-10	2022	No tap intake and categories of tap water intake produced 77% and 78% areas under the ROC curve in predicting tap water avoidance.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	3-6
35102375-10	2022	No tap intake and categories of tap water intake produced 77% and 78% areas under the ROC curve in predicting tap water avoidance.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	32-35
35102375-10	2022	No tap intake and categories of tap water intake produced 77% and 78% areas under the ROC curve in predicting tap water avoidance.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	110-113
35102375-11	2022	CONCLUSION: This study demonstrates that water intake variables from dietary recalls can be used to accurately predict tap water avoidance and provide a window into water insecurity.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	119-122
35102375-11	2022	CONCLUSION: This study demonstrates that water intake variables from dietary recalls can be used to accurately predict tap water avoidance and provide a window into water insecurity.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
35102375-12	2022	Growing reliance on bottled water may indicate increasing concerns about tap water.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
35134220-2	2022	Here, we aimed to clarify how stomatal dynamics and water use efficiency (WUE) differ in fluctuating environments in major C3 and C4 crops.	Water	52-57	complement C3	Homo sapiens	123-132
35063550-6	2022	However, bio-filtered water positively regulated the growth profile, activities of antioxidants such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), total soluble sugars, amino acids, total protein, and proline contents in wheat as compared with untreated wastewater.	Water	22-27	SOD	Triticum aestivum	104-124
35063550-6	2022	However, bio-filtered water positively regulated the growth profile, activities of antioxidants such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), total soluble sugars, amino acids, total protein, and proline contents in wheat as compared with untreated wastewater.	Water	22-27	SOD	Triticum aestivum	126-129
34982502-1	2022	BACKGROUND: Tap water iontophoresis (TWI) is an effective treatment option for palmoplantar hyperhidrosis (HH).	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
35564808-0	2022	Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study.	Water	40-45	ataxin 1 like	Homo sapiens	107-111
35470688-1	2022	We herein report the synthesis of poly (9-decenoic acid-1-vinylimidazole-N-isopropylacrylamide) nanoparticles containing indocyanine green (ICG) in one pot and in water phase throughout the reaction.	Water	163-168	mediator complex subunit 25	Homo sapiens	51-57
35625560-10	2022	Therefore, we anticipate an important physiological role of p-AQP4ex in human brain water homeostasis.	Water	84-89	aquaporin 4	Homo sapiens	62-66
35631342-9	2022	The ME1-induced barrier disruption recovered within less than 5 h after the formulation removal, as detected by transepidermal water loss measurements.	Water	127-132	malic enzyme 1	Homo sapiens	4-7
35518645-1	2022	Aquaporin-4 (AQP4) is the predominant water channel in the brain; it is enriched in astrocytic foot processes abutting vessels where it is anchored through an interaction with the dystrophin-associated protein (DAP) complex.	Water	38-43	aquaporin 4	Mus musculus	0-11
35518645-1	2022	Aquaporin-4 (AQP4) is the predominant water channel in the brain; it is enriched in astrocytic foot processes abutting vessels where it is anchored through an interaction with the dystrophin-associated protein (DAP) complex.	Water	38-43	aquaporin 4	Mus musculus	13-17
34168798-9	2021	A neutral Ac(H2O)6 (1)(O2CMe)3 (1) compound was the major species in solution for the large Ac3+.	Water	13-16	adenylate cyclase 3	Homo sapiens	92-95
34228620-3	2021	MATERIAL AND METHODS The presented study compared two groups; hand scrubbing with sensory tap was enrolled as group A and classic tap with running water was enrolled as group B.	Water	147-152	nuclear RNA export factor 1	Homo sapiens	130-133
34228620-6	2021	Running water from a tap in 10 seconds was measured with the help of a measuring cup.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	21-24
35421486-1	2022	This study reports a structured investigation on the degradation kinetics of different types (gyrAR,tetAR, qnrSR) and conformational forms (chromosomal, plasmids) of ARGs and mobile genetic elements (intl-1, plasmids) as a function of water matrix (DI water, phosphate buffer, wastewater) with UV and UV/H2O2 treatments.	Water	235-240	serpin family A member 2 (gene/pseudogene)	Homo sapiens	166-170
35421486-1	2022	This study reports a structured investigation on the degradation kinetics of different types (gyrAR,tetAR, qnrSR) and conformational forms (chromosomal, plasmids) of ARGs and mobile genetic elements (intl-1, plasmids) as a function of water matrix (DI water, phosphate buffer, wastewater) with UV and UV/H2O2 treatments.	Water	252-257	serpin family A member 2 (gene/pseudogene)	Homo sapiens	166-170
35597427-1	2022	Aquaporin-4 (AQP4) is the water regulating channel found in the terminal processes of astrocytes in the brain and is implicated in regulating the astrocyte functions, whereas in neuropathologies, AQP4 performs an important role in astrocytosis and release of proinflammatory cytokines.	Water	26-31	aquaporin 4	Homo sapiens	0-11
35597427-1	2022	Aquaporin-4 (AQP4) is the water regulating channel found in the terminal processes of astrocytes in the brain and is implicated in regulating the astrocyte functions, whereas in neuropathologies, AQP4 performs an important role in astrocytosis and release of proinflammatory cytokines.	Water	26-31	aquaporin 4	Homo sapiens	13-17
35597427-2	2022	However, several findings have revealed the modulation of the AQP4 water channel in the etiopathogenesis of various neuropsychiatric diseases.	Water	67-72	aquaporin 4	Homo sapiens	62-66
35367248-3	2022	Herein, moderate-susceptible C57BL/6J mice were immunized with inter-photoreceptor retinoid binding protein (IRBP) 651-670 to develop EAU and were kept together for mating.	Water	134-137	retinol binding protein 3, interstitial	Mus musculus	63-107
35367248-3	2022	Herein, moderate-susceptible C57BL/6J mice were immunized with inter-photoreceptor retinoid binding protein (IRBP) 651-670 to develop EAU and were kept together for mating.	Water	134-137	retinol binding protein 3, interstitial	Mus musculus	109-113
35569778-4	2022	In a model of LPS-induced inflammation, we found that hypoxia induced by infusing nitrogen into water increased the expression of pro-inflammatory cytokines, such as il-1beta, il-6, and il-8.	Water	96-101	interleukin 6 (interferon, beta 2)	Danio rerio	176-180
35178660-3	2022	Dexamethasone-induced MuRF1 expression was significantly suppressed by methanol-soluble part of boiling water extract of PA in a concentration-dependent manner with its IC50 value of 1.5 mg/ml.	Water	104-109	tripartite motif-containing 63	Mus musculus	22-27
35616204-0	2022	(Determination of four trihalomethanes in ship ballast water by gas chromatography-negative chemical ionization-mass spectrometry).	Water	55-60	inositol polyphosphate-5-phosphatase D	Homo sapiens	42-46
35616204-1	2022	Ship ballast water can control the roll, trim, and draft of the ship, and thus ensuring the balance and stability of the ship in the course of sailing, and playing a vital role in the safe navigation of ships.	Water	13-18	inositol polyphosphate-5-phosphatase D	Homo sapiens	0-4
35616204-1	2022	Ship ballast water can control the roll, trim, and draft of the ship, and thus ensuring the balance and stability of the ship in the course of sailing, and playing a vital role in the safe navigation of ships.	Water	13-18	inositol polyphosphate-5-phosphatase D	Homo sapiens	64-68
35616204-1	2022	Ship ballast water can control the roll, trim, and draft of the ship, and thus ensuring the balance and stability of the ship in the course of sailing, and playing a vital role in the safe navigation of ships.	Water	13-18	inositol polyphosphate-5-phosphatase D	Homo sapiens	121-125
35616204-2	2022	The annual discharge of ship ballast water is very large in China.	Water	37-42	inositol polyphosphate-5-phosphatase D	Homo sapiens	24-28
35616204-3	2022	About three to five billion cubic meters of ship ballast water is discharged into offshore or inland waters every year.	Water	57-62	inositol polyphosphate-5-phosphatase D	Homo sapiens	44-48
35612553-2	2022	CASE REPORT: A 19-year-old Caucasian female with no past medical history was transferred from an outside hospital and admitted to the intensive care unit for acute respiratory distress syndrome secondary to a fresh water drowning event.	Water	215-220	immunoglobulin kappa variable 2-28	Homo sapiens	13-17
35614089-6	2022	Rheotrophic-ombrotrophic mires temporarily formed due to water table fluctuations, which were strongly dependent on ever-wet climate changes and syn-depositional tectonics during the Neogene, and resulted in the balanced to high peat accumulation and preservation.	Water	57-62	synemin	Homo sapiens	145-148
35610274-1	2022	The paper presents a new analytical four-layer (air-water-bottom-non-conductive layer) horizontal electric dipole model which allows an accurate approximation of ship"s Underwater Electric Potential (UEP) from a sufficient depth in shallow coastal marine waters.	Water	52-57	inositol polyphosphate-5-phosphatase D	Homo sapiens	162-166
35506916-2	2022	The formation of Ar 2p-1 vacancies followed by non-radiative decay to intermediate one-site doubly ionized states Ar2+(3p-2)-ArM-1(H2O)N and subsequent redistribution of charge to the cluster environment are monitored.	Water	131-134	kallikrein related peptidase 4	Homo sapiens	125-130
35623187-3	2022	For instance, alkylphenols and phthalates have been frequently reported to be present both in bottled and tap water, affecting different human endpoints.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	106-109
35570674-0	2022	Perceptions of Tap Water Associated with Low-Income Michigan Mothers" and Young Children"s Beverage Intake.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
35570674-1	2022	OBJECTIVE: To quantify perceptions of tap water among low-income mothers with young children residing in Michigan and examine associations between perceptions of tap water, mothers" and young children"s beverage intake, and mothers" infant feeding practices.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
35570674-5	2022	RESULTS: Two-thirds (66.2%) of mothers reported that their home tap water was safe to drink without a filter while 21.6% were unsure about the safety of their home tap water.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
35570674-6	2022	Mothers" perceptions of their home tap water were associated with their own tap and bottled water intake and their young children"s tap water and bottled water intake.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
35570674-6	2022	Mothers" perceptions of their home tap water were associated with their own tap and bottled water intake and their young children"s tap water and bottled water intake.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	76-79
35570674-6	2022	Mothers" perceptions of their home tap water were associated with their own tap and bottled water intake and their young children"s tap water and bottled water intake.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	132-135
35570674-6	2022	Mothers" perceptions of their home tap water were associated with their own tap and bottled water intake and their young children"s tap water and bottled water intake.	Water	92-97	nuclear RNA export factor 1	Homo sapiens	35-38
35570674-6	2022	Mothers" perceptions of their home tap water were associated with their own tap and bottled water intake and their young children"s tap water and bottled water intake.	Water	136-141	nuclear RNA export factor 1	Homo sapiens	35-38
35570674-6	2022	Mothers" perceptions of their home tap water were associated with their own tap and bottled water intake and their young children"s tap water and bottled water intake.	Water	136-141	nuclear RNA export factor 1	Homo sapiens	132-135
35570674-6	2022	Mothers" perceptions of their home tap water were associated with their own tap and bottled water intake and their young children"s tap water and bottled water intake.	Water	154-159	nuclear RNA export factor 1	Homo sapiens	35-38
35570674-7	2022	Mothers with more negative perceptions of tap water in general, independent of their perceptions about their home tap water, consumed more bottled water and sugar-sweetened beverages, and their young children drank bottled water and fruit drinks more frequently.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
35570674-7	2022	Mothers with more negative perceptions of tap water in general, independent of their perceptions about their home tap water, consumed more bottled water and sugar-sweetened beverages, and their young children drank bottled water and fruit drinks more frequently.	Water	147-152	nuclear RNA export factor 1	Homo sapiens	42-45
35570674-9	2022	CONCLUSIONS: Uncertainty about tap water safety and negative perceptions of tap water are common among low-income Michigan mothers.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
35570674-9	2022	CONCLUSIONS: Uncertainty about tap water safety and negative perceptions of tap water are common among low-income Michigan mothers.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
35473765-8	2022	Females displayed greater recruitment (Fos expression) of the dorsal hippocampus than males, particularly in cold water.	Water	114-119	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-42
35502905-0	2022	Lowering the Water Oxidation Overpotential by Spin-Crossover in Cobalt Hexacyanoferrate.	Water	13-18	spindlin 1	Homo sapiens	46-50
35502905-2	2022	Manipulating the spin configuration of the water oxidation intermediates allows us to overcome these constraints.	Water	43-48	spindlin 1	Homo sapiens	17-21
35533740-9	2022	Our collective data indicate that Prl promotes FW-acclimation in mummichogs by orchestrating the expression of solute transporters/channels, water channels, and tight-junction proteins across multiple osmoregulatory organs.	Water	141-146	prolactin	Fundulus heteroclitus	34-37
35446535-5	2022	The results indicate that the MR-CNTF used as a cathodic microporous layer can remarkably facilitate the oxygen transport and water management.	Water	126-131	ciliary neurotrophic factor	Homo sapiens	33-37
27400132-0	2016	Acceptorless Dehydrogenative Cyclization of o-Aminobenzyl Alcohols with Ketones to Quinolines in Water Catalyzed by Water-Soluble Metal-Ligand Bifunctional Catalyst [Cp*(6,6"-(OH)2bpy)(H2O)][OTf]2.	Water	97-102	POU class 2 homeobox 2	Homo sapiens	191-196
35452215-4	2022	A water-splitting electrolyzer based on Pt/C  AF1-HNN8-50  NiSx/Ni(OH)2/NiOOH exhibits a current density of 1800 mA cm-2 at 2.0 V and 500 h high-rate stability at 1000 mA cm-2 with negligible attenuation of only 0.12 mV h-1.	Water	2-7	interferon gamma receptor 2	Homo sapiens	46-49
27400132-0	2016	Acceptorless Dehydrogenative Cyclization of o-Aminobenzyl Alcohols with Ketones to Quinolines in Water Catalyzed by Water-Soluble Metal-Ligand Bifunctional Catalyst [Cp*(6,6"-(OH)2bpy)(H2O)][OTf]2.	Water	116-121	POU class 2 homeobox 2	Homo sapiens	191-196
27098211-4	2016	The obtained copolymers (P1 and P2) having desirable water solubility were well-characterized by infrared spectroscopy (IR), nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), UV-Vis absorption spectroscopy, and photoluminescence spectroscopy.	Water	53-58	crystallin gamma F, pseudogene	Homo sapiens	25-34
35501348-5	2022	These structures, together with mutagenesis studies and an inactive state model obtained from metadynamics simulations, reveal a unique activation mechanism for GPR88 with a set of distinctive structure features and a water-mediated polar network.	Water	218-223	G protein-coupled receptor 88	Homo sapiens	161-166
27179856-15	2016	However, we found that some of the wavenumbers in the water absorption region are affected by the DGAT1 polymorphism and lactation stage.	Water	54-59	diacylglycerol O-acyltransferase 1	Bos taurus	98-103
35013963-9	2022	The Sava River was defined as moderately polluted regarding metals, whose water quality meets environmental quality standards (EQS).	Water	74-79	T-box transcription factor T	Homo sapiens	4-8
27250206-0	2016	Structure of Complement C3(H2O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling.	Water	27-30	complement C3	Homo sapiens	13-26
35174932-7	2022	Treatment with alpha-pinene caused Abeta-receiving rats to spend more time in the target quadrant in the Morris water maze test and led to an increase in percentages of open arm entrance and time spent in the open arm in the elevated plus-maze test.	Water	112-117	amyloid beta precursor protein	Rattus norvegicus	35-40
27250206-4	2016	This revealed details of the structural differences and similarities between C3(H2O) and C3, as well as between C3(H2O) and its pivotal proteolytic cleavage product, C3b, which shares functionally similarity with C3(H2O).	Water	115-118	complement C3	Homo sapiens	166-169
35216518-6	2022	The reduced water reabsorption appears to be mediated by atrial natriuretic peptide (ANP) because SCI increased the expression levels of both ANP and natriuretic peptide receptor A (NPR-A) in the kidney cortex.	Water	12-17	natriuretic peptide receptor 1	Mus musculus	182-187
27250206-5	2016	Considered in combination with the crystal structures of C3 and C3b, the QCMLS data suggest that C3(H2O) generation is accompanied by the migration of the thioester-containing domain of C3 from one end of the molecule to the other.	Water	100-103	complement C3	Homo sapiens	64-67
27250206-8	2016	The unique arrangement of domains thus observed in C3(H2O), which retains the anaphylatoxin domain (that is excised when C3 is enzymatically activated to C3b), can be used to rationalize observed differences between C3(H2O) and C3b in terms of complement activation and regulation.	Water	54-57	complement C3	Homo sapiens	154-157
35134442-2	2022	Aquaporin-4 (AQP4), a water channel protein expressed in astrocytes, regulates the progression of neurological diseases.	Water	22-27	aquaporin 4	Mus musculus	0-11
27250206-8	2016	The unique arrangement of domains thus observed in C3(H2O), which retains the anaphylatoxin domain (that is excised when C3 is enzymatically activated to C3b), can be used to rationalize observed differences between C3(H2O) and C3b in terms of complement activation and regulation.	Water	54-57	complement C3	Homo sapiens	228-231
35134442-2	2022	Aquaporin-4 (AQP4), a water channel protein expressed in astrocytes, regulates the progression of neurological diseases.	Water	22-27	aquaporin 4	Mus musculus	13-17
27250206-8	2016	The unique arrangement of domains thus observed in C3(H2O), which retains the anaphylatoxin domain (that is excised when C3 is enzymatically activated to C3b), can be used to rationalize observed differences between C3(H2O) and C3b in terms of complement activation and regulation.	Water	219-222	complement C3	Homo sapiens	154-157
35439261-8	2022	Changes to cell membrane water permeability due to AQP4 expression affected DWI of cell suspensions.	Water	25-30	aquaporin 4	Homo sapiens	51-55
27250206-8	2016	The unique arrangement of domains thus observed in C3(H2O), which retains the anaphylatoxin domain (that is excised when C3 is enzymatically activated to C3b), can be used to rationalize observed differences between C3(H2O) and C3b in terms of complement activation and regulation.	Water	219-222	complement C3	Homo sapiens	228-231
28920341-4	2016	The water activity-equilibrium moisture content (aw-EMC) relationship in GAB models showed, the moisture absorption of powder was increased with the rising of DE value; and the equilibrium moisture content-glass transition temperature (EMC-Tg) relationship in Gordon-Taylor models showed that, Tg was decreased with the increase of moisture content.	Water	4-9	alpha-1-B glycoprotein	Homo sapiens	73-76
35464765-4	2022	The mouse model of cognitive impairment was established by a single intracerebroventricular (ICV) injection of STZ (3.0 mg/kg), and we found that TGR5 activation by its agonist INT-777 (1.5 or 3.0 mug/mouse, ICV injection) ameliorated spatial memory impairment in the Morris water maze and Y-maze tests.	Water	275-280	G protein-coupled bile acid receptor 1	Mus musculus	146-150
35436640-8	2022	The designed sensor has a good recovery in two real samples of tap water and orange juice, indicating it can be used as an alternative detection method via comparison with other detection method.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
35451191-6	2022	Inhibition of interferon-triggered STAT1 phosphorylation by AA was reversed by water-soluble cholesterol, known to prevent the perturbation of lipid raft structure by AA.	Water	79-84	signal transducer and activator of transcription 1	Homo sapiens	35-40
27483250-1	2016	The astrocytic endfoot membranes of the healthy blood-brain barrier-contacting the capillary-are covered with a large number of the water channel aquaporin 4 (AQP4).	Water	132-137	aquaporin 4	Homo sapiens	146-157
35326020-2	2022	Methods: A total of 39 healthy young adults ingested either 1000 mL (n = 21) or 500 mL (n = 18) of tap water in 5 min.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
27483250-1	2016	The astrocytic endfoot membranes of the healthy blood-brain barrier-contacting the capillary-are covered with a large number of the water channel aquaporin 4 (AQP4).	Water	132-137	aquaporin 4	Homo sapiens	159-163
35482380-2	2022	To increase the Ca and Mg contents in the drinking water supplied to the inhabitants of the village of Devicie, a prototype of a fluidized bed recarbonization reactor (RRF) was proposed and tested.	Water	51-56	mitochondrial ribosome recycling factor	Homo sapiens	168-171
35404942-9	2022	Collectively, we find that exposure to As via drinking water is associated with alterations in Th17 numbers and IL-17A production, and that these associations may be modified by Vitamin D status.	Water	55-60	interleukin 17A	Homo sapiens	112-118
27327861-3	2016	The Fe-bearing materials also effectively activated persulfate to enhance the oxidative transformation of TNT and RDX in soil-water systems.	Water	126-131	radixin	Homo sapiens	114-117
35395735-13	2022	The elevated concentrations of fecal biomarkers of gut inflammation and the high EED disease activity score were significantly associated with open defecation practice, mouthing of soil contaminated materials, Escherichia coli (E. coli)  contamination of drinking water, E. coli contamination of foods, E. coli contamination of soil, and intestinal parasites.	Water	264-269	embryonic ectoderm development	Homo sapiens	81-84
35464881-0	2022	A batch microfabrication of a self-cleaning, ultradurable electrochemical sensor employing a BDD film for the online monitoring of free chlorine in tap water.	Water	152-157	nuclear RNA export factor 1	Homo sapiens	148-151
35482380-4	2022	In the RRF, the HBD is kept in buoyancy with the help of water circulation.	Water	57-62	mitochondrial ribosome recycling factor	Homo sapiens	7-10
35260880-1	2022	Aquaporin 4 (AQP4) is highly expressed on astrocytes and is critical for controlling brain water transport in neurological diseases.	Water	91-96	aquaporin 4	Homo sapiens	0-11
35260880-1	2022	Aquaporin 4 (AQP4) is highly expressed on astrocytes and is critical for controlling brain water transport in neurological diseases.	Water	91-96	aquaporin 4	Homo sapiens	13-17
35464881-1	2022	Free chlorine is one of the key water quality parameters in tap water.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	60-63
27226426-1	2016	Cyclic pentapeptides (e.g. Ac-(cyclo-1,5)-[KAXAD]-NH2 ; X=Ala, 1; Arg, 2) in water adopt one alpha-helical turn defined by three hydrogen bonds.	Water	77-82	arginase 2	Homo sapiens	66-72
35464881-1	2022	Free chlorine is one of the key water quality parameters in tap water.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
35464881-2	2022	However, a free chlorine sensor with the characteristics of batch processing, durability, antibiofouling/antiorganic passivation and in situ monitoring of free chlorine in tap water continues to be a challenging issue.	Water	176-181	nuclear RNA export factor 1	Homo sapiens	172-175
35464881-10	2022	The interesting sensing and self-cleaning behavior of the as-proposed sensor indicate that this study of the mass production of free chlorine sensors by MEMS is successful in developing a competitive device for the online monitoring of free chlorine in tap water.	Water	257-262	nuclear RNA export factor 1	Homo sapiens	253-256
35367430-1	2022	The increasing needs of drinking water due to population growth requires seeking for new tap water sources.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	89-92
35367430-1	2022	The increasing needs of drinking water due to population growth requires seeking for new tap water sources.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
35367430-2	2022	However, these large-scale tap water sources are oftentimes abundant with dissolved natural organic matter (NOM), such as tannic acid issue causing color in water.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
35367430-2	2022	However, these large-scale tap water sources are oftentimes abundant with dissolved natural organic matter (NOM), such as tannic acid issue causing color in water.	Water	157-162	nuclear RNA export factor 1	Homo sapiens	27-30
35367430-4	2022	This study focuses on developing and testing a suite of cost-effective, scalable, adaptable, and sustainable sorption media that can be implemented near the source locations of tap water as a pretreatment option to remove color for a long-distance interbasin transfer.	Water	181-186	nuclear RNA export factor 1	Homo sapiens	177-180
35094110-0	2022	YouTube as a source of information for water treatments.	Water	39-44	tubulin epsilon 1	Homo sapiens	0-7
27032635-6	2016	We have shown that the AAP abundance was significantly positively correlated with the water pH, and the highest proportion of photoheterotrophs was found in peat-bog lakes with a pH between 6.7 and 7.6.	Water	86-91	serpin family F member 2	Homo sapiens	23-26
35094110-1	2022	The purpose of the study was to investigate the quality and reliability of YouTube videos as a source of information in water treatments.	Water	120-125	tubulin epsilon 1	Homo sapiens	75-82
35094110-13	2022	The YouTube content linked with water treatments has poor quality and reliability most of time.	Water	32-37	tubulin epsilon 1	Homo sapiens	4-11
35085961-6	2022	The LID layout obtained from the SWMM-FTC with the GDE3 saved $210-1067 to achieve a 1% reduction in storm water runoff.	Water	107-112	glycerophosphodiester phosphodiesterase domain containing 2	Homo sapiens	51-55
35344541-8	2022	Continued post-disposal logging in new wells in the 18G disposal area on the south flank of Elk Hills shows that injected water has migrated approximately 1,200 m (4,000 ft) downdip (south) over a period of 20 years since the inception of disposal activity.	Water	122-127	potassium voltage-gated channel subfamily H member 8	Homo sapiens	92-95
27344558-0	2016	Determination of steroidal oestrogens in tap water samples using solid-phase extraction on a molecularly imprinted polymer sorbent and quantification with gas chromatography-mass spectrometry (GC-MS).	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
35393040-13	2022	According to cooling strategies, ice vests and water spray are effective in reducing Tsk and decreasing the risk of heat stroke.	Water	47-52	tsukushi, small leucine rich proteoglycan	Homo sapiens	85-88
27371173-2	2016	The AQP4 water channel is located on astrocytic end-feet processes and consists of six transmembrane helical domains forming three extracellular loops A, C, and E in which defined amino acids were already proven to be critical for AQP4-IgG binding.	Water	9-14	aquaporin 4	Homo sapiens	4-8
27371173-2	2016	The AQP4 water channel is located on astrocytic end-feet processes and consists of six transmembrane helical domains forming three extracellular loops A, C, and E in which defined amino acids were already proven to be critical for AQP4-IgG binding.	Water	9-14	aquaporin 4	Homo sapiens	231-235
35112729-0	2022	The plasma membrane aquaporin ZmPIP2;5 enhances the sensitivity of stomatal closure to water deficit.	Water	87-92	aquaporin PIP2-5	Zea mays	30-38
26285144-4	2016	RESULTS: Fitting of the model to the data allowed determination of the different parameters describing the blood water T1 such as those for the diamagnetic and paramagnetic effects of albumin and hemoglobin, and the contribution of methemoglobin.	Water	113-118	hemoglobin subunit gamma 2	Homo sapiens	232-245
35112729-6	2022	Upon mild-water deficit or low ABA concentration treatments, transpiration and gs decreased more in PIP2;5 OE, and less in pip2;5 KD lines, in comparison with WTs.	Water	10-15	aquaporin PIP2-5	Zea mays	100-106
35112729-10	2022	These data indicate that maize PIP2;5 is a key actor increasing the sensitivity of stomatal closure to water deficit.	Water	103-108	aquaporin PIP2-5	Zea mays	31-37
35355228-5	2022	In mouse ICH model, activation of RKIP remarkably improved neurological deficits, reduced brain water content and BBB disruption, and promoted hematoma absorption at 24 h after ICH, as well as alleviated neuronal degeneration, reduced membrane pore formation, and downregulated pyroptotic molecules NLRP3, caspase-1 P20, GSDMD-N, and mature IL-1beta.	Water	96-101	phosphatidylethanolamine binding protein 1	Mus musculus	34-38
35387259-0	2022	Water Treadmill Training Ameliorates Neurite Outgrowth Inhibition Associated with NGR/RhoA/ROCK by Inhibiting Astrocyte Activation following Spinal Cord Injury.	Water	0-5	ras homolog family member A	Rattus norvegicus	86-90
35401423-2	2022	About 80% of patients harbor antibodies directed against the water channel aquaporin-4 (AQP4-IgG), expressed on astrocytes, which was found to be both a biomarker and a pathogenic cause of NMOSD.	Water	61-66	aquaporin 4	Homo sapiens	88-92
27196811-2	2016	[C2mim][NTf2] is completely miscible with HNO3 but immiscible with water.	Water	67-72	nuclear transport factor 2	Homo sapiens	8-12
35329749-6	2022	Effects of calcium sulphate with different amounts of crystallisation water (anhydrite, hemihydrate and gypsum) on C3A hydration are also investigated, and it is found that the water of crystallisation does not have a significant impact on the kinetics of reaction or the formed hydrate phase assemblage.	Water	177-182	complement C3	Homo sapiens	115-118
35338149-1	2022	Despite technological advances over the last several decades, ship-based hydrography remains the only method for obtaining high-quality, high spatial and vertical resolution measurements of physical, chemical, and biological parameters over the full water column essential for physical, chemical, and biological oceanography and climate science.	Water	250-255	inositol polyphosphate-5-phosphatase D	Homo sapiens	62-66
27196811-3	2016	The triangular phase diagram of the ternary system [C2mim][NTf2]-HNO3-H2O was determined at 300.1 K. The homogeneous [C2mim][NTf2]-HNO3-H2O phase is thermodynamically stable, while it can be separated into two phases with an increase of water content.	Water	70-73	nuclear transport factor 2	Homo sapiens	59-63
35183812-5	2022	We found that treatment with Cd in drinking water (10 mg/L) for 6 or 12 weeks significantly boosted hepatic fat deposition, increased hepatocyte destruction, and amplified inflammatory responses in mice, confirming that low-dose Cd can facilitate NASH development in vivo.	Water	44-49	cathepsin D	Mus musculus	29-31
27196811-4	2016	Experiments (electrospray ionization mass spectrometry, Fourier transform infrared spectrometry, and (1)H-nuclear magnetic resonance spectrometry) and molecular dynamics simulations were carried out to investigate the interaction between [C2mim][NTf2], HNO3, and water in the homogeneous phase.	Water	263-268	nuclear transport factor 2	Homo sapiens	246-250
35274667-1	2022	In this study, using the "click-chemistry" azide-alkyne cycloaddition reaction, two new types of polymers, namely, water-soluble amine-functional and water-insoluble pyridine-functional hyperbranched 1,2,3-triazoleorganoethoxysiloxane polymers, capable of stabilizing ultra-small silver nanoparticles and efficient for chemical surface modification were synthesized and characterized by 1H-NMR, 13C-NMR, 29Si-NMR and FT-IR spectroscopy, MALDI and GPC.	Water	115-120	glycophorin C (Gerbich blood group)	Homo sapiens	447-450
27196811-6	2016	This confirms that the complexes [C2mim-NTf2-C2mim](+) and [NTf2-C2mim-NTf2](-) exist in the homogeneous [C2mim][NTf2]-HNO3-H2O system at the concentration of HNO3 up to 27.01 wt % and of water as high as 20.74 wt %.	Water	188-193	nuclear transport factor 2	Homo sapiens	40-44
35274667-1	2022	In this study, using the "click-chemistry" azide-alkyne cycloaddition reaction, two new types of polymers, namely, water-soluble amine-functional and water-insoluble pyridine-functional hyperbranched 1,2,3-triazoleorganoethoxysiloxane polymers, capable of stabilizing ultra-small silver nanoparticles and efficient for chemical surface modification were synthesized and characterized by 1H-NMR, 13C-NMR, 29Si-NMR and FT-IR spectroscopy, MALDI and GPC.	Water	150-155	glycophorin C (Gerbich blood group)	Homo sapiens	447-450
35279880-9	2022	The spatiotemporally distinct skin responses in SLPI deficient mice, compared to their wild-type littermates, resulted from a compromised skin barrier function that manifested itself in heightened transepidermal water loss through the larger skin area surrounding the imiquimod challenged skin.	Water	212-217	secretory leukocyte peptidase inhibitor	Mus musculus	48-52
27196811-6	2016	This confirms that the complexes [C2mim-NTf2-C2mim](+) and [NTf2-C2mim-NTf2](-) exist in the homogeneous [C2mim][NTf2]-HNO3-H2O system at the concentration of HNO3 up to 27.01 wt % and of water as high as 20.74 wt %.	Water	188-193	nuclear transport factor 2	Homo sapiens	60-64
35309424-6	2022	The results indicated that the P(NIPAAm-co-AAc)-grafted m-silica nanocomposites could retain water for more than 300 min at temperatures higher than the lower critical solution temperature.	Water	93-98	glycine-N-acyltransferase	Homo sapiens	43-46
35431660-9	2022	Other solvates 1X 2  MeNO2, 1X 2  MeCN, and 1X 2  H2O are mostly isomorphous with each other and show more gradual spin-crossover equilibria near room temperature.	Water	50-53	spindlin 1	Homo sapiens	115-119
35209153-0	2022	DPD Simulation on the Transformation and Stability of O/W and W/O Microemulsions.	Water	56-57	dihydropyrimidine dehydrogenase	Homo sapiens	0-3
35209153-0	2022	DPD Simulation on the Transformation and Stability of O/W and W/O Microemulsions.	Water	62-63	dihydropyrimidine dehydrogenase	Homo sapiens	0-3
35133721-4	2022	AQP4 is a bidirectional water channel directly involved in astrocyte cell volume regulation.	Water	24-29	aquaporin 4	Homo sapiens	0-4
35048936-6	2022	The N-Fe-Ni3S2@NiP2/NF electrode couple also has relatively long-term durability in alkaline solutions, maintaining a stable current density for 15 h at 1.35 V. The density functional theory (DFT) calculation shows that the in situ generated Fe doped nanooxides exhibit strong water adsorption energy, which may be one of the reasons for the good catalytic activity.	Water	277-282	neurofascin	Homo sapiens	20-22
35162031-0	2022	A Compact Fiber-Coupled NIR/MIR Laser Absorption Instrument for the Simultaneous Measurement of Gas-Phase Temperature and CO, CO2, and H2O Concentration.	Water	135-138	membrane associated ring-CH-type finger 8	Homo sapiens	28-31
35124875-0	2022	The Effects of Proline Isomerization on the Solvation Behavior of Elastin-Like Polypeptides in Water-Ethanol Mixtures.	Water	95-100	elastin	Homo sapiens	66-73
35186964-16	2021	Conclusion: Drinking tap water was associated with a low risk of OA among older adults in China.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
35140543-1	2022	With the solvothermal reactions of flexible tetracarboxylic acid ligand with the Cd(II) and Ca(II) ions, we acquired a new heterometallic coordination polymer formulated as {(Cd2Ca2(L)2(DMF)2(H2O)7) (DMF) 2(H2O)}n (1, H4L is 5-(bis(4-carboxybenzyl)amino)isophthalic acid, DMF is N,N"-Dimethylformamide).	Water	192-195	carbonic anhydrase 2	Homo sapiens	92-98
35140543-1	2022	With the solvothermal reactions of flexible tetracarboxylic acid ligand with the Cd(II) and Ca(II) ions, we acquired a new heterometallic coordination polymer formulated as {(Cd2Ca2(L)2(DMF)2(H2O)7) (DMF) 2(H2O)}n (1, H4L is 5-(bis(4-carboxybenzyl)amino)isophthalic acid, DMF is N,N"-Dimethylformamide).	Water	207-210	carbonic anhydrase 2	Homo sapiens	92-98
34995697-3	2022	While the size and zeta-potential of polyplexes were comparable among various PAsp(DET/R)s, the transfection efficiencies of polyplexes were considerably varied due to difference in the R moieties of PAsp(DET/R)s and were described by an octanol-water (or buffer at pH 7.3) distribution coefficient (logD7.3).	Water	246-251	carboxypeptidase B1	Homo sapiens	200-204
35023625-3	2022	MSP possesses good water-dispersity and high photothermal ability, which is used for photoacoustic imaging and photothermal therapy.	Water	19-24	microseminoprotein beta	Homo sapiens	0-3
35100286-9	2022	Tap water consumption was the only common risk factor identified.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
35214032-13	2022	Air and water-vapor permeabilities were affected by the mats" porosity (PCL < PCLaEOs < PCLbEOs), exhibiting a similar tendency of increasing with the increase of porosity.	Water	8-13	PHD finger protein 1	Homo sapiens	72-75
34950937-1	2022	In this paper, a smart enzyme reactor (SER) was synthesized using immobilized tyrosinase (Tyr) in a photo-responsive hydrogel via a polydopamine-assisted self-assembly strategy for purifying water from phenol contaminated water.	Water	191-196	tyrosinase	Homo sapiens	78-88
34950937-1	2022	In this paper, a smart enzyme reactor (SER) was synthesized using immobilized tyrosinase (Tyr) in a photo-responsive hydrogel via a polydopamine-assisted self-assembly strategy for purifying water from phenol contaminated water.	Water	222-227	tyrosinase	Homo sapiens	78-88
35111727-0	2021	Highly Sensitive Water Detection Through Reversible Fluorescence Changes in a syn-Bimane Based Boronic Acid Derivative.	Water	17-22	synemin	Homo sapiens	78-81
35111727-1	2021	Reported herein is a fluorometric and colorimetric sensor for the presence of trace amounts of water in organic solvents, using syn-bimane based boronate ester 1.	Water	95-100	synemin	Homo sapiens	128-131
35069523-8	2021	Furthermore, not only IL-17 but also R848 appeared to enhance the inflammatory response and to impair the barrier function of the RPE, indicating that TLR7 signaling is involved in the pathogenesis of EAU by affecting the behaviors of the RPE and consequently allowing the infiltration of autoreactive T cells intraocularly.	Water	201-204	toll-like receptor 7	Mus musculus	151-155
31651225-0	2022	Containers that enable blind people to determine the level of contained hot water.	Water	76-81	alcohol dehydrogenase iron containing 1	Homo sapiens	72-75
31651225-2	2022	In this work, three non-powered containers were designed to assist blind people in detecting the level of hot water in a container.	Water	110-115	alcohol dehydrogenase iron containing 1	Homo sapiens	106-109
34985218-5	2022	In this method, AOX in textiles were extracted by ultrasonic extraction at room temperature with ultra-pure water as solvent.	Water	108-113	acyl-CoA oxidase 1	Homo sapiens	16-19
35098233-3	2022	This method has been applied to the synthesis of a polymer/graphene conjugate and a water-soluble protein/polymer conjugate, demonstrating the first examples of CMRP in graphene and protein conjugation.	Water	84-89	ATP binding cassette subfamily C member 2	Homo sapiens	161-165
35386591-4	2022	In the present study, Tyrobp-/- mice showed learning and memory deficits in the Morris water maze, which worsened with age.	Water	87-92	TYRO protein tyrosine kinase binding protein	Mus musculus	22-28
35329749-0	2022	Effect of Water-Solid Mixing Sequence and Crystallization Water of Calcium Sulphate on the Hydration of C3A.	Water	10-15	complement C3	Homo sapiens	104-107
35329749-0	2022	Effect of Water-Solid Mixing Sequence and Crystallization Water of Calcium Sulphate on the Hydration of C3A.	Water	58-63	complement C3	Homo sapiens	104-107
35303915-3	2022	METHOD: BDNF microspheres were prepared by using an oil-in-water emulsification-solvent evaporation method.	Water	59-64	brain-derived neurotrophic factor	Rattus norvegicus	8-12
35329561-0	2022	Accelerated Curing for Glass-Based Mortars Using Water at 80  C. The substitution of river sand with glass aggregate (GA) and cement with glass powder (GP) is a mainstream method to recycle waste glass.	Water	49-54	gp	Drosophila melanogaster	152-154
35329561-9	2022	In particular, when applying the 1-day water curing at 80  C, GA mortars containing GP (47.9 mum) can even gain higher strength than those containing fly ash.	Water	39-44	gp	Drosophila melanogaster	84-86
35260622-1	2022	Harvesting of flow current through implanted hydrophobic surface within silicone pipe as liquid nanogenerators where Tap water (TW), and DI water (DIw) as liquid reservoirs to successfully convert induced mechanical energy into electrical energy.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
35175041-2	2022	In particular, tissues that carry blood and water produce the lowest PA background in the wavelength range of 1050 to 1150 nm.	Water	44-49	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	123-125
35148326-4	2022	The water holding capacity ranged from 2.10 to 3.20 mgL-1 and carbon exchange capacity was 1250 to 4202 meq/100g.	Water	4-9	LLGL scribble cell polarity complex component 1	Homo sapiens	52-57
35185853-4	2022	The co-occurrence networks showed distinct interconnective characteristics in different MPBs: The structure of MPB incubated in the lake water sample was more robust under environmental stresses, and bacteria in the tap water MPB interacted more cooperatively.	Water	220-225	nuclear RNA export factor 1	Homo sapiens	216-219
35185853-5	2022	Regarding this cooperative interaction, the analysis of functional prediction, in this study, also showed that more symbionts and parasites colonized on microplastics in the tap water than in the lake water.	Water	178-183	nuclear RNA export factor 1	Homo sapiens	174-177
35185853-6	2022	Moreover, it was suggested that MPBs were more easily formed in the tap water sample.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
35074739-12	2022	In addition, AOM exhibited to be more toxic to the colon in the nitrite-treated mice in comparison with normal water-treated mice, and it might be due to the expression of Hspa1a and Hspa1b in the colon.	Water	111-116	heat shock protein 1A	Mus musculus	172-178
35044769-3	2022	We, herein, demonstrated an extremely simple but extraordinary effective strategy to boost PEC water splitting in a three-dimensional (3D) network structure (Ni foam, i.e., NF)-supported ZnO nanowire (NW)/CdS nanoparticle (NP) (NF/ZnO/CdS) photoelectrode.	Water	95-100	neurofascin	Homo sapiens	173-175
35044769-3	2022	We, herein, demonstrated an extremely simple but extraordinary effective strategy to boost PEC water splitting in a three-dimensional (3D) network structure (Ni foam, i.e., NF)-supported ZnO nanowire (NW)/CdS nanoparticle (NP) (NF/ZnO/CdS) photoelectrode.	Water	95-100	neurofascin	Homo sapiens	228-230
35091654-5	2022	The experimental results showed that the hydrophobicity (as assessed by the water contact angle), photocatalytic properties and self-cleaning efficiency of the SCF were all enhanced with increasing TiO2 content in the ABS/TiO2 fibers.	Water	76-81	KIT ligand	Homo sapiens	160-163
35126529-4	2022	A Chi-square test was conducted to examine the association between various demographic factors and having latrine/tap water.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
35126529-7	2022	Water service (solely tap water) coverage was very low (7.6%) as a result of deficient water sources and nonfunctioning pipelines.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	22-25
35126529-7	2022	Water service (solely tap water) coverage was very low (7.6%) as a result of deficient water sources and nonfunctioning pipelines.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
35126529-8	2022	The zones, age, educational status, marital status, and family size of the participants were statistically significantly associated with having latrine or tap water, p < 0.05.	Water	159-164	nuclear RNA export factor 1	Homo sapiens	155-158
35072772-14	2022	Taken together, we provide evidence for AQP4 expression in the CP of the aging brain which likely contributes to the water flow through the CP epithelium and CSF production.	Water	117-122	aquaporin 4	Mus musculus	40-44
35061526-0	2022	Field theory spin and momentum in water waves.	Water	34-39	spindlin 1	Homo sapiens	13-17
35061526-5	2022	There, the canonical momentum is associated with the generalized Stokes drift phenomenon, while the spin is generated by subwavelength circular motion of water particles.	Water	154-159	spindlin 1	Homo sapiens	100-104
35146484-7	2022	Heterozygosity of Hexb in App KI/KI mice reduced learning flexibility during the Reversal Phase of the Morris water maze.	Water	110-115	hexosaminidase B	Mus musculus	18-22
35204856-0	2022	Association of Consuming Tap Water or Purified Water during Infancy with Irritable Bowel Syndrome in Children.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
35204856-1	2022	OBJECTIVE: The objective of this study was to analyze the effect of consuming formula powder prepared with tap water or purified water during the first 4 to 6 months of life on the subsequent development of irritable bowel syndrome (IBS).	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
35204856-8	2022	RESULTS: After weighting, there were 73,355 children in the tap water group and 73,351 in the purified water group.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
34985285-2	2022	These reactions go by a common acyl-enzyme thioester intermediate, which is either attacked by water (for a protease-AEP) or by a peptidic amine nucleophile (for a ligase-AEP) to form the respective hydrolysis or aminolysis product.	Water	95-100	legumain	Homo sapiens	117-120
34990144-1	2022	In nature, water is oxidized by plastoquinone to evolve O2 and form plastoquinol in Photosystem II (PSII), whereas NADP+ is reduced by plastoquinol to produce NADPH and regenerate plastoquinone in Photosystem I (PSI), using homogeneous molecular photocatalysts.	Water	11-16	2,4-dienoyl-CoA reductase 1	Homo sapiens	159-164
35425275-11	2022	Tap water samples from a residential area were tested using these sensors, which showed good agreement with standard colorimetric measurement methods.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
34982023-0	2022	Could the region you live in prevent or precipitate kidney stone formation due to mineral intake through tap water?	Water	109-114	nuclear RNA export factor 1	Homo sapiens	105-108
34982023-3	2022	METHODS: Data from six water companies providing tap water to nine regions in Flanders regarding calcium, magnesium, potassium, sodium and sulphate content in tap water was retrieved.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	49-52
34982023-3	2022	METHODS: Data from six water companies providing tap water to nine regions in Flanders regarding calcium, magnesium, potassium, sodium and sulphate content in tap water was retrieved.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
34982023-3	2022	METHODS: Data from six water companies providing tap water to nine regions in Flanders regarding calcium, magnesium, potassium, sodium and sulphate content in tap water was retrieved.	Water	163-168	nuclear RNA export factor 1	Homo sapiens	159-162
35111770-2	2021	Antibodies directed against aquaporin-4 (AQP-4), a water channel expressed on the astrocytic membrane, are supposed to play a pathogenic role and are detected in ~80% of cases.	Water	51-56	aquaporin 4	Homo sapiens	28-39
35111770-2	2021	Antibodies directed against aquaporin-4 (AQP-4), a water channel expressed on the astrocytic membrane, are supposed to play a pathogenic role and are detected in ~80% of cases.	Water	51-56	aquaporin 4	Homo sapiens	41-46
35017583-6	2022	Moreover, the fluoride ions from PVDF promote side reactions, and LiPF6 salt forms POF3 and HF, which cause side reactions owing to hydrolysis in organic solvents containing water.	Water	174-179	forkhead box L2	Homo sapiens	83-87
34996075-3	2022	Autoantibodies targeting the water channel protein aquaporin-4 (AQP4) and the myelin sheath protein myelin oligodendrocyte glycoprotein are the major antigen-specific serological biomarkers known to date, with destruction of astrocytes as the primary mode of CNS damage in AQP4-positive disease.	Water	29-34	aquaporin 4	Homo sapiens	51-62
34996075-3	2022	Autoantibodies targeting the water channel protein aquaporin-4 (AQP4) and the myelin sheath protein myelin oligodendrocyte glycoprotein are the major antigen-specific serological biomarkers known to date, with destruction of astrocytes as the primary mode of CNS damage in AQP4-positive disease.	Water	29-34	aquaporin 4	Homo sapiens	64-68
35008929-4	2022	We concluded that CAM-based therapies have demonstrated benefits for controlling EAU severity with decreases in immune cell migration, especially via ICAM-1/LFA-1 and VCAM-1/VLA-4 (integrin) pathways.	Water	81-84	intercellular adhesion molecule 1	Homo sapiens	150-156
34975343-2	2022	Astrocytic water channel aquaporin-4 (AQP-4) system is closely related to the brain edema, water transport at blood-brain barrier (BBB) and astrocyte function in the central nervous system (CNS).	Water	11-16	aquaporin 4	Mus musculus	38-43
34975343-2	2022	Astrocytic water channel aquaporin-4 (AQP-4) system is closely related to the brain edema, water transport at blood-brain barrier (BBB) and astrocyte function in the central nervous system (CNS).	Water	91-96	aquaporin 4	Mus musculus	38-43
35094362-5	2022	The NIR imaging agent, ICG-p28, a water-soluble, nontoxic, and pan-tumor targeting probe consisting of a cell-penetrating peptide (p28) conjugated to indocyanine green (ICG), can accurately localize tumors in vivo.	Water	34-39	golgi SNAP receptor complex member 1	Homo sapiens	27-30
35094362-5	2022	The NIR imaging agent, ICG-p28, a water-soluble, nontoxic, and pan-tumor targeting probe consisting of a cell-penetrating peptide (p28) conjugated to indocyanine green (ICG), can accurately localize tumors in vivo.	Water	34-39	golgi SNAP receptor complex member 1	Homo sapiens	131-134
27196811-6	2016	This confirms that the complexes [C2mim-NTf2-C2mim](+) and [NTf2-C2mim-NTf2](-) exist in the homogeneous [C2mim][NTf2]-HNO3-H2O system at the concentration of HNO3 up to 27.01 wt % and of water as high as 20.74 wt %.	Water	188-193	nuclear transport factor 2	Homo sapiens	60-64
27196811-6	2016	This confirms that the complexes [C2mim-NTf2-C2mim](+) and [NTf2-C2mim-NTf2](-) exist in the homogeneous [C2mim][NTf2]-HNO3-H2O system at the concentration of HNO3 up to 27.01 wt % and of water as high as 20.74 wt %.	Water	188-193	nuclear transport factor 2	Homo sapiens	60-64
27306053-4	2016	Acclimation to high-Cl(-) artificial water stimulated the mRNA expression of cgrp and the receptor (crlr1) when compared with low-Cl(-) CGRP knockdown induced upregulation of the Na(+)-Cl(-) co-transporter (ncc2b), while overexpression of CGRP resulted in the downregulation of ncc2b mRNA synthesis and a simultaneous decrease in Cl(-) uptake in embryos.	Water	37-42	calcitonin/calcitonin-related polypeptide, alpha	Danio rerio	77-81
27306053-4	2016	Acclimation to high-Cl(-) artificial water stimulated the mRNA expression of cgrp and the receptor (crlr1) when compared with low-Cl(-) CGRP knockdown induced upregulation of the Na(+)-Cl(-) co-transporter (ncc2b), while overexpression of CGRP resulted in the downregulation of ncc2b mRNA synthesis and a simultaneous decrease in Cl(-) uptake in embryos.	Water	37-42	calcitonin receptor-like a	Danio rerio	100-105
27306053-4	2016	Acclimation to high-Cl(-) artificial water stimulated the mRNA expression of cgrp and the receptor (crlr1) when compared with low-Cl(-) CGRP knockdown induced upregulation of the Na(+)-Cl(-) co-transporter (ncc2b), while overexpression of CGRP resulted in the downregulation of ncc2b mRNA synthesis and a simultaneous decrease in Cl(-) uptake in embryos.	Water	37-42	calcitonin/calcitonin-related polypeptide, alpha	Danio rerio	136-140
27306053-4	2016	Acclimation to high-Cl(-) artificial water stimulated the mRNA expression of cgrp and the receptor (crlr1) when compared with low-Cl(-) CGRP knockdown induced upregulation of the Na(+)-Cl(-) co-transporter (ncc2b), while overexpression of CGRP resulted in the downregulation of ncc2b mRNA synthesis and a simultaneous decrease in Cl(-) uptake in embryos.	Water	37-42	calcitonin/calcitonin-related polypeptide, alpha	Danio rerio	239-243
27306006-1	2016	We measured equilibrium constants for H3O(+)(H2O)n-1 + H2O H3O(+)(H2O)n (n = 4-9) reactions taking place in an ion drift tube with various applied electric fields at gas temperatures of 238-330 K. The zero-field reaction equilibrium constants were determined by extrapolation of those obtained at non-zero electric fields.	Water	45-48	H3 clustered histone 15	Homo sapiens	38-41
27306006-1	2016	We measured equilibrium constants for H3O(+)(H2O)n-1 + H2O H3O(+)(H2O)n (n = 4-9) reactions taking place in an ion drift tube with various applied electric fields at gas temperatures of 238-330 K. The zero-field reaction equilibrium constants were determined by extrapolation of those obtained at non-zero electric fields.	Water	55-58	H3 clustered histone 15	Homo sapiens	38-41
27306006-1	2016	We measured equilibrium constants for H3O(+)(H2O)n-1 + H2O H3O(+)(H2O)n (n = 4-9) reactions taking place in an ion drift tube with various applied electric fields at gas temperatures of 238-330 K. The zero-field reaction equilibrium constants were determined by extrapolation of those obtained at non-zero electric fields.	Water	55-58	H3 clustered histone 15	Homo sapiens	59-62
27306006-1	2016	We measured equilibrium constants for H3O(+)(H2O)n-1 + H2O H3O(+)(H2O)n (n = 4-9) reactions taking place in an ion drift tube with various applied electric fields at gas temperatures of 238-330 K. The zero-field reaction equilibrium constants were determined by extrapolation of those obtained at non-zero electric fields.	Water	55-58	H3 clustered histone 15	Homo sapiens	38-41
27306006-1	2016	We measured equilibrium constants for H3O(+)(H2O)n-1 + H2O H3O(+)(H2O)n (n = 4-9) reactions taking place in an ion drift tube with various applied electric fields at gas temperatures of 238-330 K. The zero-field reaction equilibrium constants were determined by extrapolation of those obtained at non-zero electric fields.	Water	55-58	H3 clustered histone 15	Homo sapiens	59-62
27306006-5	2016	Furthermore, the size dependence of the parameter was thought to reflect the evolution of the hydrogen-bond structure of H3O(+)(H2O)n with the cluster size.	Water	128-131	H3 clustered histone 15	Homo sapiens	121-124
27163638-2	2016	Plasma membrane intrinsic protein 2;1 (PIP2;1), which forms a water channel that regulates water flux thorough the plasma membrane (PM), is constitutively trafficked between the PM and the trans-Golgi network (TGN) in Arabidopsis thaliana.	Water	62-67	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	0-37
27163638-2	2016	Plasma membrane intrinsic protein 2;1 (PIP2;1), which forms a water channel that regulates water flux thorough the plasma membrane (PM), is constitutively trafficked between the PM and the trans-Golgi network (TGN) in Arabidopsis thaliana.	Water	62-67	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	39-45
27163638-3	2016	Salt stress is known to relocalize PIP2;1 to intracellular compartments, probably to decrease the water permeability of the root.	Water	98-103	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	35-41
27167503-3	2016	Twenty crystal structures of BRPF1/ligand complexes show structural conservation in the acetyllysine binding site, common binding motifs, and unusual interactions (e.g., the replacement of a conserved water molecule).	Water	201-206	bromodomain and PHD finger containing 1	Homo sapiens	29-34
27267213-3	2016	Recently, there have been increased uses of bottled drinking water in an assumption that the bottled water is safer than the tap water and its use will help to protect from water-related diseases.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	125-128
27267213-8	2016	RESULTS: One hundred percent of the tap water samples and 87.5 % of the bottled water samples were found to be contaminated with heterotrophic bacteria.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
27267213-9	2016	Of the tap water samples, 55.3 % were positive for total coliforms, compared with 25 % of the bottled water.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
27267213-10	2016	No bottled water samples were positive for fecal coliforms and fecal streptococci, in contrast to 21.1 % and 14.5 % of the tap water samples being contaminated with fecal coliforms and fecal streptococci, respectively.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
27267213-11	2016	One hundred percent of the tap water samples and 54.2 % of the bottled water samples had pH in the acceptable range.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
27257989-5	2016	Further, through oral administration of recombinant chicken IFN alpha in drinking water, we provide direct evidence that type I IFN can promote rapid induction of adaptive immune responses and protective efficacy of influenza vaccine in chickens.	Water	82-87	interferon	Gallus gallus	60-69
27125576-2	2016	Herein we report a facile synthetic approach to cobalt nanocrystal assembled hollow nanoparticles (Co-HNP), which serve as an electrocatalyst for hydrogen generation from neutral-pH water.	Water	182-187	kallikrein related peptidase 8	Homo sapiens	102-105
27021217-6	2016	Radon inhalation or hot spring water drinking significantly inhibited elevations in serum uric acid levels through the suppression of xanthine oxidase activity in the liver.	Water	31-36	xanthine dehydrogenase	Mus musculus	134-150
27126699-5	2016	The withdrawal latency of the tail from 0 C water was prolonged in TRPA1(-/-), but not TRPV1(-/-), mice compared to respective wild-types.	Water	44-49	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	67-72
26908046-0	2016	Novel Water-Borne Polyurethane Nanomicelles for Cancer Chemotherapy: Higher Efficiency of Folate Receptors Than TRAIL Receptors in a Cancerous Balb/C Mouse Model.	Water	6-11	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	112-117
27138325-3	2016	The water peak in the NMR spectrum was selectively saturated, and the STD amplitudes for TBP were observed in the presence of TiO2, demonstrating that the side chains of the N-terminal residues Arg1 and Lys2 exhibit the strongest saturation transfer effect from water molecules; i.e., the two N-terminal residues are in contact with the TiO2 surface.	Water	4-9	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	203-207
27138325-3	2016	The water peak in the NMR spectrum was selectively saturated, and the STD amplitudes for TBP were observed in the presence of TiO2, demonstrating that the side chains of the N-terminal residues Arg1 and Lys2 exhibit the strongest saturation transfer effect from water molecules; i.e., the two N-terminal residues are in contact with the TiO2 surface.	Water	262-267	TATA-box binding protein	Homo sapiens	89-92
27138325-3	2016	The water peak in the NMR spectrum was selectively saturated, and the STD amplitudes for TBP were observed in the presence of TiO2, demonstrating that the side chains of the N-terminal residues Arg1 and Lys2 exhibit the strongest saturation transfer effect from water molecules; i.e., the two N-terminal residues are in contact with the TiO2 surface.	Water	262-267	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	203-207
27147356-6	2016	The image of the tap-water phantom showed almost the same distribution as that of the pure-water phantom.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
27107665-10	2016	IL-17A Ab significantly reduced brain water content and improved neurological function of ICH mice.	Water	38-43	interleukin 17A	Mus musculus	0-6
27095837-8	2016	Transport assays in oocytes showed NIP4;1 and NIP4;2 function as water and nonionic channels.	Water	65-70	NOD26-like intrinsic protein 4;1	Arabidopsis thaliana	35-41
27095837-9	2016	We also found that NIP4;1 and NIP4;2 C termini are phosphorylated by a pollen-specific CPK that modifies their water permeability.	Water	111-116	NOD26-like intrinsic protein 4;1	Arabidopsis thaliana	19-25
27250476-1	2016	We develop a novel dielectric barrier discharge (DBD) system with a meshed water electrode to generate stable square superlattice patterns (MSSP) in Ar/air mixture in a wide range of experimental environments.	Water	75-80	RNA binding motif single stranded interacting protein 1	Homo sapiens	140-144
27025158-1	2016	Langmuir films of [C18mim][NTf2] ionic liquid exhibited, for the first time, the reversible formation of crystalline-like structures at the surface of water, compatible with the formation of multilayers.	Water	151-156	nuclear transport factor 2	Homo sapiens	27-31
26876862-1	2016	In this work, we have proven that starch nanofibrous membranes with high tensile strength, water stability and non-cytotoxicity can be produced by electrospinning of starch solution and post-treatment with GTA in vapor phase.	Water	91-96	integrin subunit alpha 2b	Homo sapiens	206-209
26876862-2	2016	GTA vapor phase crosslinking plays a key role in forming water-stable nanofiber membrane and improving the mechanical properties.	Water	57-62	integrin subunit alpha 2b	Homo sapiens	0-3
27094433-0	2016	A Novel Liquid-Liquid Extraction for the Determination of Nicotine in Tap Water, Wastewater, and Saliva at Trace Levels by GC-MS.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
27094433-8	2016	The spiking experiments yielded satisfactory recoveries of 97.6 +- 3.5, 96.8 +- 1.1, and 85.1 +- 1.3% for tap water, wastewater, and saliva samples, respectively.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	106-109
26969931-1	2016	RATIONALE: Charged species such as formylium (CHO(+) ), hydronium (H3 O(+) ), and water clusters [H3 O(+) (H2 O)n ] are commonly found in flames.	Water	82-87	H3 clustered histone 15	Homo sapiens	98-105
27162558-7	2016	A kinetic study on sTCO diastereomers in 55:45 MeOH:water showed that the syn-diastereomer displayed slightly faster reactivity than the anti-diastereomer.	Water	52-57	synemin	Homo sapiens	74-77
26593550-6	2016	The process of boiling tap water (containing HAAs) for the preparation of powdered infant formula did not remove them; therefore it would be advisable to prepare this type of milk with mineral water (free of HAAs).	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
27642318-0	2016	Simultaneous Determination of 13 Priority Polycyclic Aromatic Hydrocarbons in Tehran"s Tap Water and Water for Injection Samples Using Dispersive Liquid-Liquid Micro Extraction Method and Gas Chromatography-Mass Spectrometry.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
27642318-8	2016	The concentration of PAHs in all tap water as well as water for injection samples were lower than the limit of quantification of PAHs.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
27065810-7	2016	Water deprivation significantly reduced freezing and immobility behaviors evoked by innate fear and behavioral despair, respectively, accompanied by decreased Fos expression in the lateral habenula.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	159-162
26786101-4	2016	Non-tetrameric AQP4 mutants are unable to relocalize to the plasma membrane in response to changes in extracellular tonicity, despite equivalent constitutive surface expression levels and water permeability to wild-type AQP4.	Water	188-193	aquaporin 4	Homo sapiens	15-19
26939064-3	2016	The addition of 1 mum glucose oxidase (GOx) to water/solvent mixtures enables polymerization reactions to proceed in extremely low volumes (40 muL) and low radical concentrations.	Water	47-52	hydroxyacid oxidase 1	Homo sapiens	22-37
26939064-3	2016	The addition of 1 mum glucose oxidase (GOx) to water/solvent mixtures enables polymerization reactions to proceed in extremely low volumes (40 muL) and low radical concentrations.	Water	47-52	hydroxyacid oxidase 1	Homo sapiens	39-42
27031475-3	2016	Aquaporin-4 (AQP4) is the major aquaporin in the mammalian brain, is mostly expressed on astrocytic endfeet, and functions as a water transporter.	Water	128-133	aquaporin 4	Homo sapiens	13-17
26575716-4	2016	The constants m0 and C of BET and GAB equations were determined to be between 2.54 and 5.03 g water per 100 g of dry matter and 4.96-16.57, respectively.	Water	94-99	alpha-1-B glycoprotein	Homo sapiens	34-37
26862992-0	2016	Evaluating a Tap Water Contamination Incident Attributed to Oil Contamination by Nontargeted Screening Strategies.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
26862992-1	2016	The present study applied nontargeted screening techniques as a novel approach to evaluate the tap water samples collected during the "4.11" tap water pollution incident occurred on April 11, 2014 in Lanzhou in west China.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
26862992-1	2016	The present study applied nontargeted screening techniques as a novel approach to evaluate the tap water samples collected during the "4.11" tap water pollution incident occurred on April 11, 2014 in Lanzhou in west China.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	141-144
26862992-1	2016	The present study applied nontargeted screening techniques as a novel approach to evaluate the tap water samples collected during the "4.11" tap water pollution incident occurred on April 11, 2014 in Lanzhou in west China.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	95-98
26862992-1	2016	The present study applied nontargeted screening techniques as a novel approach to evaluate the tap water samples collected during the "4.11" tap water pollution incident occurred on April 11, 2014 in Lanzhou in west China.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
26862992-2	2016	Multivariate analysis (PCA and OPLS-DA) of about 3000 chemical features obtained in extracts of tap water samples by ultrahigh-pressure liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) analysis showed significantly different chemical profiles in tap water from pollution regions versus reference regions during the event.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
26862992-5	2016	A consistent finding was further observed in the targeted analysis of NA mixtures, demonstrating that the Lanzhou "4.11" tap water pollution incident could be attributed to oil spill pollution, and NA mixtures would be a marker for oil contamination.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
26979693-3	2016	Remarkably, the partial charge on the hydrogen atom of the optimized H3O(+) force field is 0.8 +- 0.1 e --significantly higher than the value typically used for nonpolarizable water models and H3O(+) force fields.	Water	176-181	H3 clustered histone 15	Homo sapiens	69-72
26968975-14	2016	CONCLUSIONS: Preexisting systemic inflammation plus a short severe hypoxia elicits cerebral edema through upregulated AQP4 and water permeability by TLR4 and CRH/CRHR1 signaling.	Water	127-132	corticotropin releasing hormone receptor 1	Rattus norvegicus	162-167
27054094-10	2016	Low limits of quantification for tap water (4 ng/L) and river water (20 ng/L) using only 800 muL of sample; recoveries &gt; 97%.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
26880377-6	2016	Consistent with the observation of differential bindings, ClC-ec1 exhibits markedly variable ability to support the formation of the transient water wires, which are necessary to support the connection of the two H+ transfer sites (Gluin and Gluex), in the presence of different anions.	Water	143-148	Charcot-Leyden crystal galectin	Homo sapiens	58-61
26829156-0	2016	Widespread Occurrence of Benzotriazoles and Benzothiazoles in Tap Water: Influencing Factors and Contribution to Human Exposure.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
26829156-2	2016	This study demonstrates widespread occurrence of these compounds in tap water from 51 major cities in China, which have ranges of &lt;LOQ-310 ng/L for SigmaBTRs (median: 15.6 ng/L) and 40.1-1310 ng/L for SigmaBTHs (median: 406 ng/L).	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
26829156-4	2016	Difference of concentration level and compound profile of BTRs and BTHs in tap water and their surface water source, as well as in wastewater treatment plant effluents, is described.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
26761525-0	2016	Effects of protein flexibility and active site water molecules on the prediction of sites of metabolism for cytochrome P450 2C19 substrates.	Water	47-52	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	108-128
26761525-4	2016	In this study, we systematically evaluated the effects of protein flexibility and active site water molecules on SOM prediction for CYP2C19 substrates.	Water	94-99	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	132-139
26756917-7	2016	Possibly, four conserved water molecules stabilize oxyanion hole in unliganded state, but they vacate these positions when the enzyme (hGMPS)-substrate complex is formed.	Water	25-30	guanine monophosphate synthase	Homo sapiens	135-140
26534997-7	2016	CPAP levels were set at 4, 5, 6, 7, 8, and 9 cm H2O with flows of 6, 8, and 10 L/min each.	Water	48-51	centromere protein J	Homo sapiens	0-4
26534997-14	2016	RESULTS: At lower set CPAP levels, 4-6 cm H2O, measured CPAP dropped precipitously with the nasal prongs with the highest flow setting.	Water	42-45	centromere protein J	Homo sapiens	22-26
26534997-14	2016	RESULTS: At lower set CPAP levels, 4-6 cm H2O, measured CPAP dropped precipitously with the nasal prongs with the highest flow setting.	Water	42-45	centromere protein J	Homo sapiens	56-60
26534997-15	2016	At higher CPAP levels, 7-9 cm H2O measured CPAP concomitantly increased as the flow setting increased.	Water	30-33	centromere protein J	Homo sapiens	10-14
26534997-15	2016	At higher CPAP levels, 7-9 cm H2O measured CPAP concomitantly increased as the flow setting increased.	Water	30-33	centromere protein J	Homo sapiens	43-47
26577198-7	2016	CPAP at 15 cm H2O resulted in the highest albuterol delivery (P = .02).	Water	14-17	centromere protein J	Homo sapiens	0-4
26856374-2	2016	Utilizing highly fluorescent and water-dispersible ultrathin g-C3N4 nanosheets, a highly sensitive, selective and label-free biosensor has been developed for ALP detection for the first time.	Water	33-38	ATHS	Homo sapiens	158-161
26889917-4	2016	Water soluble keratin was first extracted from human hair and mixed with PCL in different ratios.	Water	0-5	PHD finger protein 1	Homo sapiens	73-76
26735740-1	2016	This research focused on the synthesis, characterization, and performance testing of a novel Magneli phase (TinO2n-1), n = 4 to 6, reactive electrochemical membrane (REM) for water treatment.	Water	175-180	mex-3 RNA binding family member D	Homo sapiens	108-112
26599146-7	2016	Radon concentrations obtained in water and air of the spa are high, with an average of 660 Bq/l and 2900 Bq/m(3) respectively, where water is the main source of radon in the air.	Water	33-38	surfactant protein A2	Homo sapiens	54-57
26599146-7	2016	Radon concentrations obtained in water and air of the spa are high, with an average of 660 Bq/l and 2900 Bq/m(3) respectively, where water is the main source of radon in the air.	Water	133-138	surfactant protein A2	Homo sapiens	54-57
26599150-6	2016	The range of DCIM concentrations in Nicosia tap water samples was narrower (0.032 - 0.848 mug L(-1)).	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
26599150-7	2016	Mean total iodine concentration in tap water samples from the seaside city of Limassol was 15 mug L(-1) and approximately twice to those observed in samples from the mainland Nicosia city.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
26745628-7	2016	Findings of our in silico study strongly point to the closed-like conformation as the most likely for a Josephin Domain in water.	Water	123-128	ataxin 3	Homo sapiens	104-112
28955842-3	2016	First, we confirmed that ceramics could transform tap water into active tap water by increasing water permeability through aquaporin.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
28955842-3	2016	First, we confirmed that ceramics could transform tap water into active tap water by increasing water permeability through aquaporin.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	72-75
28955842-3	2016	First, we confirmed that ceramics could transform tap water into active tap water by increasing water permeability through aquaporin.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	50-53
28955842-3	2016	First, we confirmed that ceramics could transform tap water into active tap water by increasing water permeability through aquaporin.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
28955842-3	2016	First, we confirmed that ceramics could transform tap water into active tap water by increasing water permeability through aquaporin.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	50-53
28955842-3	2016	First, we confirmed that ceramics could transform tap water into active tap water by increasing water permeability through aquaporin.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
28955842-5	2016	The distilled water was determined to exhibit the same aquaporin permeability as the original tap water.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
26515811-1	2016	Global ship-based programs, with highly accurate, full water column physical and biogeochemical observations repeated decadally since the 1970s, provide a crucial resource for documenting ocean change.	Water	55-60	inositol polyphosphate-5-phosphatase D	Homo sapiens	7-11
26398585-1	2016	BACKGROUND AND PURPOSE: Most of the cases of neuromyelitis optica (NMO) are characterized by the presence of an autoantibody, NMO-IgG, which recognizes the extracellular domains of the water channel, aquaporin-4.	Water	185-190	aquaporin 4	Homo sapiens	200-211
26398585-3	2016	One therapeutic option for NMO is to prevent the binding of NMO-IgG to aquaporin-4, using high-avidity, non-pathogenic-chimeric, monoclonal antibodies to this water channel.	Water	159-164	aquaporin 4	Homo sapiens	71-82
27924798-10	2016	CONCLUSIONS: A 3-week treatment with 1 l/day of the sulfate-rich mineral water improved the frequency of bowel movements in subjects with FC compared with tap water; however, the difference was no longer significant after 6 weeks.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	155-158
27081247-2	2016	Tap water iontophoresis is reliable and effective method for treatment of palmar and plantar hyperhydrosis when practiced with appropriate technique and timing.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
27213050-0	2016	1,3-Propanediol binds inside the water-conducting pore of aquaporin 4: Does this efficacious inhibitor have sufficient potency?	Water	33-38	aquaporin 4	Homo sapiens	58-69
27213050-2	2016	Therefore, researchers have been looking for ways to inhibit AQP4"s water-conducting function.	Water	68-73	aquaporin 4	Homo sapiens	61-65
27213050-5	2016	Using the same method, we examine the possibility of plugging up the AQP4 channel around the Asn-Pro-Ala motifs located near the channel center because a small molecule bound there would totally occlude water conduction through AQP4.	Water	203-208	aquaporin 4	Homo sapiens	69-73
27213050-5	2016	Using the same method, we examine the possibility of plugging up the AQP4 channel around the Asn-Pro-Ala motifs located near the channel center because a small molecule bound there would totally occlude water conduction through AQP4.	Water	203-208	aquaporin 4	Homo sapiens	228-232
26948324-9	2016	The inhibitors of Na/H exchanger, NKCC and AQP4 may attenuate brain edema formation through inhibition of excessive transportation of ion and water from blood into the cerebral tissue.	Water	142-147	aquaporin 4	Homo sapiens	43-47
26696154-3	2016	A new series of BaO-SnO-P2O5 glass characterized with a very low photoelastic constant of ~0.08  B, high refractive index (~1.66), and better water durability is a candidate for precise polarization control devices such as optical filters and beam splitters.	Water	142-147	strawberry notch homolog 2	Homo sapiens	20-23
26360456-7	2016	The results showed that the highest PFASs concentrations were found in tap water samples and the more frequently found compound was perfluorooctanesulfonic acid (PFOS), with mean concentrations of 7.73, 15.33 and 15.83ng/l in French, Spanish and Brazilian samples, respectively.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
26360456-8	2016	In addition, PFOS was detected in all tap water samples from Brazil.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
26360456-9	2016	The highest level of PFASs contamination in a single sample was 140.48ng/l in a sample of Spanish tap water.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
28035177-9	2016	Reverse water gas shift decreased the H2/CO ratio.	Water	8-13	relaxin 2	Homo sapiens	38-43
26153439-0	2016	Ephedra water decoction and cough tablets containing ephedra and liquorice induce CYP1A2 but not CYP2E1 hepatic enzymes in rats.	Water	8-13	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	82-88
26568372-1	2015	The size-controlled growth of nanocrystalline Fe-Fe2O3 particles (2-3 nm) and their concomitant dispersion on N-doped graphene (Fe-Fe2O3/NGr) could be attained when the mutually assisted redox reaction between NGr and Fe(3+) ions could be controlled within the aqueous droplets of a water-in-oil emulsion.	Water	283-288	reticulon 4 receptor	Homo sapiens	137-140
26627307-4	2015	Here, we demonstrate that in the presence of Boc-7-aminoheptanoic acid (Boc-7), phase separation occurs in mixtures of miscible organic solvent and water.	Water	148-153	BOC cell adhesion associated, oncogene regulated	Homo sapiens	72-75
26468265-7	2015	In addition, we showed that water deprivation alone upregulated proopiomelanocortin, Agouti-related peptide, melanin-concentrating hormone, and orexin A mRNA levels in the hypothalamus, and that CB1Rs regulate main central peptidergic pathways controlling food intake, being that most of these effects were also significantly influenced by the hydration status.	Water	28-33	cannabinoid receptor 1	Rattus norvegicus	195-198
26468265-8	2015	In conclusion, the present study demonstrated that CB1Rs participate in the homeostatic responses regulating fluid balance and energy homeostasis during water deprivation.	Water	153-158	cannabinoid receptor 1	Rattus norvegicus	51-54
26440788-2	2015	We review the state-of-the-art of STH quantification in soil, biosolids, water, produce, and vegetation with regard to four major methodological issues: environmental sampling; recovery of STHs from environmental matrices; quantification of recovered STHs; and viability assessment of STH ova.	Water	73-78	saitohin	Homo sapiens	34-37
26538670-0	2015	Primary portal vein hypoplasia and SLC2A9 mutation associated with urate urolithiasis in a Spanish water dog.	Water	99-104	solute carrier family 2 member 9	Canis lupus familiaris	35-41
26538670-1	2015	This report describes a Spanish water dog with an ammonium urate urethrolith which was diagnosed with primary portal vein hypoplasia and was found to be homozygous for the mutated SLC2A9 gene.	Water	32-37	solute carrier family 2 member 9	Canis lupus familiaris	180-186
26538670-2	2015	This is the first Spanish water dog described with the SLC2A9 mutation and the first case of concurrent portal vascular abnormalities and SLC2A9 mutation.	Water	26-31	solute carrier family 2 member 9	Canis lupus familiaris	55-61
26538670-2	2015	This is the first Spanish water dog described with the SLC2A9 mutation and the first case of concurrent portal vascular abnormalities and SLC2A9 mutation.	Water	26-31	solute carrier family 2 member 9	Canis lupus familiaris	138-144
26303408-1	2015	X-ray structures of G protein-coupled receptors (GPCRs) have now been reported for more than 60 ligands and 20 receptors, including examples from GPCR classes A, B, C and F. The new structures show previously unobtainable details of interactions between GPCRs and ligands, including the roles of lipophilic regions and water molecules as key drivers of binding.	Water	319-324	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	49-53
26094108-4	2015	With this conservative scenario, it can be seen that tap water makes a minor but potentially non-negligible contribution for a few micropollutants, by comparison with diet and air.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
26318666-1	2015	A water-soluble polysaccharide (MCP) was isolated from the fruits of Momordica charantia L., and the hypoglycemic effects of MCP were investigated in both normal healthy and alloxan-induced diabetic mice.	Water	2-7	CD46 antigen, complement regulatory protein	Mus musculus	32-35
26321425-2	2015	MDG-1, a water-soluble beta-d-fructan extracted from the roots of Ophiopogon japonicus, has potent anti-obesity and hypoglycemic effects.	Water	9-14	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	0-5
26995869-7	2015	These results highlight the ability of TaqMan PCR assays using dried saliva on water-soluble paper in genotyping of ADH1B and ALDH2 genes.	Water	79-84	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	116-121
26506001-12	2015	Even though access to piped water supplies is low in Uvira, improving the reliability of tap water supply may substantially reduce the incidence of suspected cholera, in particular in neighbourhoods having a higher access to tap water.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
26506001-12	2015	Even though access to piped water supplies is low in Uvira, improving the reliability of tap water supply may substantially reduce the incidence of suspected cholera, in particular in neighbourhoods having a higher access to tap water.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	225-228
26091681-9	2015	The best model explaining variations of NCl3 air levels (r2 = 0.83) included sampling period (P = 0.002, NCl3 was higher in the evening versus the morning), water changes (P = 0.02, NCl3 was lower with water changes between 60 and 90 min day(-1) versus &lt;60 min day(-1)), and ventilation (P = 0.0002, NCl3 was lower with &gt;=2 air changes per hour (ACH) versus &lt;1 ACH).	Water	157-162	calpain 5	Homo sapiens	40-44
26308926-0	2015	Different senescent HDPE pipe-risk: brief field investigation from source water to tap water in China (Changsha City).	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
26152845-3	2015	Recombinant murine subunits of the RBP-3 protein were purified and used to immunize C57BL/6J mice to induce EAU.	Water	108-111	retinol binding protein 3, interstitial	Mus musculus	35-40
26079808-2	2015	In patients with NMO, the target antigen is aquaporin-4 (AQP4), the most abundant water channel protein in the CNS.	Water	82-87	aquaporin 4	Homo sapiens	44-55
26079808-2	2015	In patients with NMO, the target antigen is aquaporin-4 (AQP4), the most abundant water channel protein in the CNS.	Water	82-87	aquaporin 4	Homo sapiens	57-61
26564508-10	2015	Fifteen IMN patients were positive for PLA2R by using water bath heat repair plus trypsin repair,protease K digestion repair,and pepsin digestion repair, but the distribution of positive deposits and the background were different.	Water	54-59	phospholipase A2 receptor 1	Homo sapiens	39-44
26423139-1	2015	BACKGROUND: Astrocytes expressing the aquaporin-4 water channel are a primary target of pathogenic, disease-specific immunoglobulins (IgG) found in patients with neuromyelitis optica (NMO).	Water	50-55	aquaporin 4	Homo sapiens	38-49
26123277-1	2015	Hexavalent chromium (Cr6) is a drinking water contaminant that has been detected in most of the water systems throughout the United States.	Water	40-45	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	21-24
26123277-1	2015	Hexavalent chromium (Cr6) is a drinking water contaminant that has been detected in most of the water systems throughout the United States.	Water	96-101	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	21-24
26371025-1	2015	Municipal tap water is increasingly treated at the point of use (POU) to improve the acceptability and palatability of its taste.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
26252808-2	2015	Herein, we present experimental and theoretical structural and chemical characterization of [(TBP)2Al2(mu4-O8)(Al28(mu2-OH)56(H2O)22)](14+) (TBP = t-butylphosphonate), denoted as (TBP)2Al30-S. We go on to consider the structure as a model for studying the reactivity of oxyanions to aluminum hydroxide surfaces.	Water	126-129	TATA-box binding protein	Homo sapiens	94-97
26252808-2	2015	Herein, we present experimental and theoretical structural and chemical characterization of [(TBP)2Al2(mu4-O8)(Al28(mu2-OH)56(H2O)22)](14+) (TBP = t-butylphosphonate), denoted as (TBP)2Al30-S. We go on to consider the structure as a model for studying the reactivity of oxyanions to aluminum hydroxide surfaces.	Water	126-129	TATA-box binding protein	Homo sapiens	141-144
26252808-2	2015	Herein, we present experimental and theoretical structural and chemical characterization of [(TBP)2Al2(mu4-O8)(Al28(mu2-OH)56(H2O)22)](14+) (TBP = t-butylphosphonate), denoted as (TBP)2Al30-S. We go on to consider the structure as a model for studying the reactivity of oxyanions to aluminum hydroxide surfaces.	Water	126-129	TATA-box binding protein	Homo sapiens	141-144
29449928-0	2015	Fluorine teams up with water to restore inhibitor activity to mutant BPTI.	Water	23-28	spleen trypsin inhibitor I	Bos taurus	69-73
29449928-4	2015	High resolution crystal structures were obtained for four BPTI variants in complex with bovine beta-trypsin, revealing changes in the stoichiometry and dynamics of water molecules in the S1 subsite.	Water	164-169	spleen trypsin inhibitor I	Bos taurus	58-62
26153538-6	2015	When these HSC-like cells were transplanted into irradiated immunodeficient mice and they were supplied with a dox-containing water, CD4/8 double negative T cells were detected in their thymi.	Water	126-131	CD4 antigen	Mus musculus	133-136
25640014-12	2015	To sum up, our work demonstrated that SIRT1 had a pivotally protective role in the regulation of EPCs apoptosis induced by H(2)O(2) and that SIRT1 protected against apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and subsequent degradation.	Water	123-128	sirtuin 1	Homo sapiens	38-43
25599980-0	2015	Transcription co-activator Arabidopsis ANGUSTIFOLIA3 (AN3) regulates water-use efficiency and drought tolerance by modulating stomatal density and improving root architecture by the transrepression of YODA (YDA).	Water	69-74	Protein kinase superfamily protein	Arabidopsis thaliana	201-205
26753282-1	2015	A hydrophilic interaction chromatographic (HILIC) method has been developed for the determination of the four carbapenems in human urine and tap water.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
26149956-1	2015	Three KPC-2-producing Escherichia coli (E1, E2, and E3) were recovered from water samples of an urban river in the city of Harbin, China.	Water	76-81	KPC-2	Escherichia coli	6-11
26287615-1	2015	Mammalian aquaporin 1 (AQP1) is well known to function as a membrane channel for H2O and CO2 transport.	Water	81-84	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	10-21
26287615-1	2015	Mammalian aquaporin 1 (AQP1) is well known to function as a membrane channel for H2O and CO2 transport.	Water	81-84	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	23-27
26309858-2	2015	METHODS: EAU was induced in rats using peptides 1169 to 1191 of the interphotoreceptor binding protein (IRBP).	Water	9-12	retinol binding protein 3	Rattus norvegicus	68-102
26309858-2	2015	METHODS: EAU was induced in rats using peptides 1169 to 1191 of the interphotoreceptor binding protein (IRBP).	Water	9-12	retinol binding protein 3	Rattus norvegicus	104-108
26148430-5	2015	Contrary to an acyclic glucopyranose-based NN ligand unable to interact with a phosphane ligand, the CD-based PNN ligands stabilized the catalytic species in water by supramolecular means.	Water	158-163	pinin, desmosome associated protein	Homo sapiens	110-113
26140361-5	2015	In addition, the sPA recognition of the triazolium cyclodextrin click cluster in water was confirmed by fluorescence titration.	Water	81-86	surfactant protein A2	Homo sapiens	17-20
25841997-9	2015	CONCLUSION: Education, home safety checks along with thermometers or thermostatic mixing valves should be promoted to reduce tap water scalds.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
26136201-12	2015	The complex is readily soluble in water and keeps its pharmacological activity against U87 tumor cells (IC50=0.028 +- 0.007 muM vs. 0.018 +- 0.003 muM for PhtFerr).	Water	34-39	small nucleolar RNA, C/D box 87	Homo sapiens	87-90
25228753-3	2015	UMOD has been linked to water/electrolyte balance and to kidney innate immunity and it is believed to protect against urinary tract infections and renal stones.	Water	24-29	uromodulin	Homo sapiens	0-4
26019132-13	2015	CONCLUSION: Chlorogenic acid is a water-soluble agent that promotes CFTR-mediated Cl(-) transport in mouse and human sinonasal epithelium.	Water	34-39	cystic fibrosis transmembrane conductance regulator	Mus musculus	68-72
26138128-10	2015	Mincle small interfering RNA reduced interleukin-1beta and infiltration of myeloperoxidase positive cells, decreased brain water content, and improved neurological functions at 24 hours after SAH.	Water	123-128	C-type lectin domain family 4, member E	Rattus norvegicus	0-6
26114840-7	2015	The practical utility of the method is well tested with tap water.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
26055250-2	2015	While only a two-water-bridged H3O(+)(H2O)2H3O(+) is found in hydronium cluster calculations, three clusters of HO(-)(H2O)2HO(-), HO(-)(H2O)3HO(-) and HO(-)(H2O)4HO(-) are stable dihydroxide aggregates.	Water	17-22	H3 clustered histone 15	Homo sapiens	31-34
26055250-2	2015	While only a two-water-bridged H3O(+)(H2O)2H3O(+) is found in hydronium cluster calculations, three clusters of HO(-)(H2O)2HO(-), HO(-)(H2O)3HO(-) and HO(-)(H2O)4HO(-) are stable dihydroxide aggregates.	Water	38-41	H3 clustered histone 15	Homo sapiens	31-34
26182107-1	2015	We propose a simple extension of the well known ST2 model for water [F. H. Stillinger and A. Rahman, J. Chem.	Water	62-67	ST2	Homo sapiens	48-51
26182107-6	2015	Our study definitively proves that the liquid-liquid transition in the ST2 model is a genuine phenomenon, of high relevance in all tetrahedral network-forming liquids, including water.	Water	178-183	ST2	Homo sapiens	71-74
26135148-8	2015	and the validity of its conclusion that hot water immersion is most effective for the relief of pain from Bluebottle stings.	Water	44-49	alcohol dehydrogenase iron containing 1	Homo sapiens	40-43
26092033-22	2015	The decision to implement a water fluoridation programme relies upon an understanding of the population"s oral health behaviour (e.g. use of fluoride toothpaste), the availability and uptake of other caries prevention strategies, their diet and consumption of tap water and the movement/migration of the population.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	260-263
25528218-6	2015	For typical dietary constituents, only tap water is probably locally derived and bottled water may not be.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
26028872-11	2015	CONCLUSION: Chlorhexidine, warm salt water and warm tap water averagely produced the same number of colony forming units of bacteria, which shows that the three different mouth washes are equally effective as post-operative mouth rinses after oral surgery.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
26014494-10	2015	To confirm the magnitude and temperature dependence, the experiment was repeated by two of the observers with a mixture of ice and water at 0  C and with thermalized tap water at 21  C room temperature.	Water	170-175	nuclear RNA export factor 1	Homo sapiens	166-169
26185772-1	2015	Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water channel, which is abundant in astrocytic foot processes.	Water	165-170	aquaporin 4	Homo sapiens	146-157
26185772-1	2015	Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water channel, which is abundant in astrocytic foot processes.	Water	165-170	aquaporin 4	Homo sapiens	159-163
25853330-0	2015	Functionalization of the PEG Corona of Nanoparticles by Clip Photochemistry in Water: Application to the Grafting of RGD Ligands on PEGylated USPIO Imaging Agent.	Water	79-84	CAP-Gly domain containing linker protein 1	Homo sapiens	56-60
25853330-4	2015	We found that the clip photochemistry in water is a robust and efficient method to functionalize PEG.	Water	41-46	CAP-Gly domain containing linker protein 1	Homo sapiens	18-22
25792738-1	2015	Neuromyelitis optica-immunoglobulin G (NMO-IgG) binds to aquaporin-4 (AQP4) water channels in the central nervous system leading to immune-mediated injury.	Water	76-81	aquaporin 4	Homo sapiens	57-68
25792738-1	2015	Neuromyelitis optica-immunoglobulin G (NMO-IgG) binds to aquaporin-4 (AQP4) water channels in the central nervous system leading to immune-mediated injury.	Water	76-81	aquaporin 4	Homo sapiens	70-74
26263322-1	2015	We report that at ambient temperature and with 100% enriched para-hydrogen (p-H2) dissolved in organic solvents, paramagnetic spin catalysis of para   ortho hydrogen conversion is accompanied at the onset by a negative ortho-hydrogen (o-H2) proton NMR signal.	Water	235-239	polyhomeotic homolog 2	Homo sapiens	76-80
25902004-8	2015	We propose that this RDS may originate from the slow removal of a solvent ligand in the intermediate [Co(I)(kappa(4)-L)(OH2)](+) in addition to the significant structural reorganization of the metal complex and surrounding solvent resulting in a high free energy of activation.	Water	120-124	peripherin 2	Homo sapiens	21-24
26214894-3	2015	Some bacterial strains isolated from water and periphyton of enclosures hydrolyzed collagen (5-23 U/ml) and elastin (20-32 U/ml).	Water	37-42	elastin	Homo sapiens	108-115
25627253-4	2015	Microarray analysis demonstrated that expression of water deprivation-responsive genes was higher in the absence of dehydration stress in transgenic Arabidopsis plants expressing green fluorescent protein-tagged LKP2 (GFP-LKP2) than in control transgenic plants expressing GFP.	Water	52-57	LOV KELCH protein 2	Arabidopsis thaliana	212-216
25627253-4	2015	Microarray analysis demonstrated that expression of water deprivation-responsive genes was higher in the absence of dehydration stress in transgenic Arabidopsis plants expressing green fluorescent protein-tagged LKP2 (GFP-LKP2) than in control transgenic plants expressing GFP.	Water	52-57	LOV KELCH protein 2	Arabidopsis thaliana	222-226
25687671-2	2015	At the site, tap water and treated wastewater were intermittently infiltrated into a porous aquifer via a small pilot pond.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
25933791-0	2015	On the ambiguity of conformational states: A B&amp;S-LEUS simulation study of the helical conformations of decaalanine in water.	Water	122-127	leucyl-tRNA synthetase 1	Homo sapiens	53-57
25849905-5	2015	Chronic intra-hippocampal BDNF administration rescued learning deficits in the water maze, whereas infusions of NGF and NT-3 did not influence the behavioral performance of rats injected with Abeta1-42.	Water	79-84	brain-derived neurotrophic factor	Rattus norvegicus	26-30
25728657-11	2015	The developed method was applied to water samples (tap and swimming pool water).	Water	36-41	nuclear RNA export factor 1	Homo sapiens	51-54
25603543-13	2015	CONCLUSION: The activation of mAChR induced AQP5 translocation to the nucleus, APM and LPM, and AQP5 may trigger water transport across the nuclear membrane and plasma membrane in rat parotid acinar cells.	Water	113-118	aquaporin 5	Rattus norvegicus	96-100
25603543-14	2015	GENERAL SIGNIFICANCE: AQP5 translocates to the nuclear membrane and may trigger the movement of water, inducing shrinkage of the nucleus and the start of nuclear functions.	Water	96-101	aquaporin 5	Rattus norvegicus	22-26
25540452-7	2015	Specifically, we find that, under benign soil-water conditions, transgenic lines containing different AREB1 alleles differ in the expression of a large number of genes associated with pathogen response.	Water	46-51	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	102-107
25795972-0	2015	[Tap water as a dietary source of exposure to fluoride in Tenerife; risk assessment].	Water	5-10	nuclear RNA export factor 1	Homo sapiens	1-4
25795972-7	2015	METHOD: 44 samples of tap water collected in the 11 municipalities in the study were analyzed using the fluoride potentiometric determination with an ion selective electrode.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
25795972-8	2015	RESULTS: 9 of the 11 municipalities presented mean fluoride concentrations in their tap water that exceeded the parametric value set by the Spanish legislation (1.5 mg/L).	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
25577227-9	2015	ORS with 500 ml of water is an effective therapy for VVS.	Water	19-24	VVS	Homo sapiens	53-56
26281563-0	2015	[Study on inhibitory effect of water extract of Polygonum multiflorum on CYP1A2 and CYP2E1 enzymatic activities and mRNA expressions in rat liver].	Water	31-36	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	73-79
25563940-2	2015	The water-soluble Az2-PEG exhibits efficient trans-to-cis isomerization of the terminal azobenzene moieties under UV-light irradiation and readily switched back to the initial trans state under visible light.	Water	4-9	ornithine decarboxylase antizyme 2	Homo sapiens	18-21
25738615-1	2015	This paper uses the binding pocket of human carbonic anhydrase II (HCAII, EC 4.2.1.1) as a tool to examine the properties of Hofmeister anions that determine (i) where, and how strongly, they associate with concavities on the surfaces of proteins and (ii) how, upon binding, they alter the structure of water within those concavities.	Water	303-308	carbonic anhydrase 2	Homo sapiens	44-65
25808768-3	2015	Since the water areas in SAR images have the lowest amplitude value, the thresholding method using SAR amplitude could effectively extract water bodies.	Water	10-15	sarcosine dehydrogenase	Homo sapiens	25-28
25808768-3	2015	Since the water areas in SAR images have the lowest amplitude value, the thresholding method using SAR amplitude could effectively extract water bodies.	Water	10-15	sarcosine dehydrogenase	Homo sapiens	99-102
25656755-2	2015	Based on several independent quantum calculations, this appears to be the HCl(H2O)4 cluster, which dissociates into the so-called solvent ion pair (SIP), H3O(+)(H2O)3Cl(-).	Water	78-81	H3 clustered histone 15	Homo sapiens	154-157
25656755-2	2015	Based on several independent quantum calculations, this appears to be the HCl(H2O)4 cluster, which dissociates into the so-called solvent ion pair (SIP), H3O(+)(H2O)3Cl(-).	Water	161-164	H3 clustered histone 15	Homo sapiens	154-157
25834422-2	2015	MRI signal intensity is related to the relaxation times (T 1, spin-lattice relaxation and T 2, spin-spin relaxation) of in vivo water protons.	Water	128-133	solute carrier family 25 member 5	Homo sapiens	90-93
22199153-5	2015	The quality of the local environment, measured by access to tap water, was a significant factor for rural residents.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
25460197-4	2015	In addition, we investigated whether oxidative-mediated protein damage can affect aquaporin-4 (AQP4), a water channel implicated in brain excitability and epilepsy.	Water	104-109	aquaporin 4	Homo sapiens	82-93
25460197-10	2015	The resulting generation of HNE targets AQP4, affecting water and ion balance.	Water	56-61	aquaporin 4	Homo sapiens	40-44
25460197-11	2015	Therefore, we suggest that seizure induces oxidative damage as well as neuronal loss, thereby promoting neuronal hyperexcitability, also affecting water and ion balance by AQP4 modulation, and thus generating a vicious cycle.	Water	147-152	aquaporin 4	Homo sapiens	172-176
25878680-17	2015	P90 showed the lowest microleakage during storage in water.	Water	53-58	cellular inhibitor of PP2A	Homo sapiens	0-3
25267303-6	2015	In examples of the SUOX-fold and DMSOR-fold enzymes, we observe three types of histidine-containing charge-transfer relays that can: (1) connect the piperazine ring of the pyranopterin to the substrate-binding site (SUOX-fold enzymes); (2) provide inter-pyranopterin communication (DMSOR-fold enzymes); and (3) connect a pyran ring oxygen to deeply buried water molecules (the DMSOR-fold NarGHI-type nitrate reductases).	Water	356-361	sulfite oxidase	Homo sapiens	19-23
25267303-6	2015	In examples of the SUOX-fold and DMSOR-fold enzymes, we observe three types of histidine-containing charge-transfer relays that can: (1) connect the piperazine ring of the pyranopterin to the substrate-binding site (SUOX-fold enzymes); (2) provide inter-pyranopterin communication (DMSOR-fold enzymes); and (3) connect a pyran ring oxygen to deeply buried water molecules (the DMSOR-fold NarGHI-type nitrate reductases).	Water	356-361	sulfite oxidase	Homo sapiens	216-220
25729581-8	2015	Water influx into the binding domain of Pgp may play a role in catalytic transition and drug expulsion.	Water	0-5	phosphoglycolate phosphatase	Mus musculus	40-43
25708299-4	2015	In this study, we discovered that mutations in the structurally buried D38 residue of PP2Calpha (PPM1A) redefined the water-mediated hydrogen network in the active site and selectively disrupted M2 metal ion binding.	Water	118-123	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	86-95
25708299-4	2015	In this study, we discovered that mutations in the structurally buried D38 residue of PP2Calpha (PPM1A) redefined the water-mediated hydrogen network in the active site and selectively disrupted M2 metal ion binding.	Water	118-123	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	97-102
25879490-4	2015	In a case-control study among kindergarten children, we compared cases and controls regarding environmental exposure, use of swimming pools, zoo visits and tap water consumption 14 days pre-onset or a corresponding 14-days-period (controls) and adjusted for residence.	Water	160-165	nuclear RNA export factor 1	Homo sapiens	156-159
25600809-8	2015	We have found that CdCl2 intake in the drinking water led to the inhibition of 35% and 30% of MMP2 and MMP9 (p &lt; 0.05) at the ventral prostate and testis, respectively, in Cd(2+) treated animals when compared to controls.	Water	48-53	matrix metallopeptidase 9	Rattus norvegicus	103-107
25681923-1	2015	A (1)H and (19)F nuclear magnetic resonance study of [Mg(H2O)6](BF4)2 has confirmed the existence of two phase transitions at Tc1   257 K and Tc2   142 K, detected earlier by the DSC method.	Water	57-60	transcriptional and immune response regulator	Homo sapiens	126-129
25681923-7	2015	The phase transition at Tc1 is associated with a sudden change of speed of fast (tauR   10(-12) s) reorientational motions of H2O ligands.	Water	126-129	transcriptional and immune response regulator	Homo sapiens	24-27
25253043-9	2015	Moreover, Pearson"s correlation analysis indicated that Actinobacteria was positively correlated with the levels of total alkalinity and dissolved organic carbon in tap water, while Firmicutes had a significant positive correlation with nitrite nitrogen.	Water	169-174	nuclear RNA export factor 1	Homo sapiens	165-168
25196960-5	2015	Of the 14 pharmaceutical compounds selected, nine were identified in tap water of Beijing downtown with the concentration up to 38.24 ng/L (carbamazepine), and the concentration levels of detected pharmaceuticals in tap water (&lt;5 ng/L for most pharmaceuticals) were lower than previous studies in other countries.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
25196960-5	2015	Of the 14 pharmaceutical compounds selected, nine were identified in tap water of Beijing downtown with the concentration up to 38.24 ng/L (carbamazepine), and the concentration levels of detected pharmaceuticals in tap water (&lt;5 ng/L for most pharmaceuticals) were lower than previous studies in other countries.	Water	220-225	nuclear RNA export factor 1	Homo sapiens	216-219
25557910-5	2015	To acidify the enamel further we exposed Cftr-null mice to fluoride in drinking water to stimulate proton release during formation of hypermineralized lines.	Water	80-85	cystic fibrosis transmembrane conductance regulator	Mus musculus	41-45
25326370-5	2015	Under progressive water stress, all transgenic events showed increased DREB1A gene expression before 50 % of soil moisture was lost (50 % FTSW or fraction of transpirable soil water), with a faster DREB1A transcript accumulation in RD2 at 85 % FTSW.	Water	18-23	dehydration response element B1A	Arabidopsis thaliana	71-77
25326370-5	2015	Under progressive water stress, all transgenic events showed increased DREB1A gene expression before 50 % of soil moisture was lost (50 % FTSW or fraction of transpirable soil water), with a faster DREB1A transcript accumulation in RD2 at 85 % FTSW.	Water	18-23	dehydration response element B1A	Arabidopsis thaliana	198-204
25326370-9	2015	These results indicate the implicit influence of rd29A::DREB1A on mechanisms underlying water uptake, stomatal response, transpiration efficiency and rooting architecture in water-stressed plants.	Water	88-93	dehydration response element B1A	Arabidopsis thaliana	56-62
25574772-9	2015	Source water bacteriology was found to have the greatest effect on tank water and biofilm bacteriology, an effect confirmed by a controlled study comparing ultrasonic and boiler humidifiers fed with tap vs. treated (deionized, reverse osmosis, 0.2 mum filtered) water over a period of two months.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	199-202
26084164-5	2015	The water activity-equilibrium moisture content (aw-EMC) and the equilibrium moisture content-Tg (EMC-Tg) relationships were fitted by GAB equation and Gordon-Taylor model respectively, and the state diagram of kouyanqing powder was obtained to guide the rational storage conditions.	Water	4-9	alpha-1-B glycoprotein	Homo sapiens	135-138
25604731-5	2015	The role of aquaporin-4 (AQP4) in water transport has been extensively investigated in the central nervous system (CNS).	Water	34-39	aquaporin 4	Mus musculus	12-23
25604731-5	2015	The role of aquaporin-4 (AQP4) in water transport has been extensively investigated in the central nervous system (CNS).	Water	34-39	aquaporin 4	Mus musculus	25-29
25513829-0	2015	Residential tap water contamination following the Freedom Industries chemical spill: perceptions, water quality, and health impacts.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
25513829-6	2015	Flushing reduced tap water 4-methylcyclohexanemethanol (4-MCHM) concentrations within some but not all homes.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
25553360-6	2015	In contrast to conventional MPs, LSA-MPs exhibited significantly improved CL detection, because of the introduction of LSA, which was made of water-soluble carboxymethylated beta-1,3-glucan.	Water	142-147	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	174-182
25085618-3	2015	Results indicate that although violations of the current chromium regulation limit in tap water are very rare, 25% of cases showed Cr(VI) concentrations above 10 mug/L, whereas Cr(VI) was detectable in 70% of the samples (&gt;2 mug/L).	Water	90-95	nuclear RNA export factor 1	Homo sapiens	86-89
25921118-1	2015	OBJECTIVE: This study aimed to evaluate the prevalence of skin lesions, which is a health effect of chronic arsenic (As) exposure, and determine the hair/blood arsenic concentrations of people living in Kutahya villages who are using and drinking tap water with a high concentration of arsenic.	Water	251-256	nuclear RNA export factor 1	Homo sapiens	247-250
25898079-6	2015	The removal rate of Na(+) in ADE was above 95% and the citric acid production was even higher than that with tap water.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
25705548-4	2015	The detection limits as determined in deionized water spiked with PBDEs are 1.71-5.82 ng/L for BDE 28, BDE 47, BDE 190, and BDE 209 and 45.55-69.95 ng/L for BDE 99 and BDE 153.	Water	48-53	homeobox D13	Homo sapiens	95-98
25705548-4	2015	The detection limits as determined in deionized water spiked with PBDEs are 1.71-5.82 ng/L for BDE 28, BDE 47, BDE 190, and BDE 209 and 45.55-69.95 ng/L for BDE 99 and BDE 153.	Water	48-53	homeobox D13	Homo sapiens	95-98
25705548-4	2015	The detection limits as determined in deionized water spiked with PBDEs are 1.71-5.82 ng/L for BDE 28, BDE 47, BDE 190, and BDE 209 and 45.55-69.95 ng/L for BDE 99 and BDE 153.	Water	48-53	homeobox D13	Homo sapiens	95-98
25705548-4	2015	The detection limits as determined in deionized water spiked with PBDEs are 1.71-5.82 ng/L for BDE 28, BDE 47, BDE 190, and BDE 209 and 45.55-69.95 ng/L for BDE 99 and BDE 153.	Water	48-53	homeobox D13	Homo sapiens	95-98
25705548-4	2015	The detection limits as determined in deionized water spiked with PBDEs are 1.71-5.82 ng/L for BDE 28, BDE 47, BDE 190, and BDE 209 and 45.55-69.95 ng/L for BDE 99 and BDE 153.	Water	48-53	homeobox D13	Homo sapiens	95-98
24764271-4	2015	beta-Dicalcium silicate (beta-C2S) and tricalcium aluminate (C3A) are Portland cement components, these compounds react with water to form hydrated phases that enhance mechanical strength of the end products.	Water	125-130	complement C3	Homo sapiens	61-64
26328349-1	2015	Nano-structured photocatalyst P25 was electrochemically hydrogenated through being immersed in 0.01 M NaOH solution to act as cathode to electrolyze water.	Water	149-154	tubulin polymerization promoting protein	Homo sapiens	30-33
25174305-2	2015	AQP4 is a water channel localized in the endofoot of astrocytes in the brain, and its expression is upregulated after a stab wound to the mouse brain or the injection of methylmercury in common marmosets.	Water	10-15	aquaporin 4	Mus musculus	0-4
25449874-1	2015	Aquaporin-4 (AQP4) is a water channel expressed in astrocyte end-feet lining the blood-brain barrier.	Water	24-29	aquaporin 4	Mus musculus	0-11
25449874-1	2015	Aquaporin-4 (AQP4) is a water channel expressed in astrocyte end-feet lining the blood-brain barrier.	Water	24-29	aquaporin 4	Mus musculus	13-17
25814919-4	2015	The water-soluble fraction of CBG-CS-2 has high anti-inflammatory activity in LPS-induced Raw264.7 macrophages.	Water	4-9	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	30-33
25985122-0	2015	An on-line spectrophotometric determination of trace amounts of thiourea in tap water, orange juice, and orange peel samples using multi-channel flow injection analysis.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
25985122-1	2015	In this work, a flow injection analysis (FIA) method was introduced for the determination of trace amounts of thiourea in tap water.	Water	126-131	nuclear RNA export factor 1	Homo sapiens	122-125
26863809-10	2015	Among women who took vitamin complexes, inadequate supply with water-soluble vitamins C, B2 and B6 was detected less frequently (the difference was significant for vitamin B2) than among women who did not intake vitamin complexes (in 11.9, 27.7 and 42.4% vs 16.1, 54.8 and 48.8 %).	Water	63-68	immunoglobulin kappa variable 5-2	Homo sapiens	89-98
25958631-9	2015	When compared with drinking tap water, OR for drinking well water was 1.770 (95% CI 1.001 - 2.444), 2.442 for drinking river water (95% CI 0.956 - 3.950), 2.554 for drinking house and field ditch water (95% CI 1.961 - 6.584), and 3.121 for drinking pond water (95% CI 1.872 - 6.566).	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
25958631-9	2015	When compared with drinking tap water, OR for drinking well water was 1.770 (95% CI 1.001 - 2.444), 2.442 for drinking river water (95% CI 0.956 - 3.950), 2.554 for drinking house and field ditch water (95% CI 1.961 - 6.584), and 3.121 for drinking pond water (95% CI 1.872 - 6.566).	Water	60-65	nuclear RNA export factor 1	Homo sapiens	28-31
25958631-9	2015	When compared with drinking tap water, OR for drinking well water was 1.770 (95% CI 1.001 - 2.444), 2.442 for drinking river water (95% CI 0.956 - 3.950), 2.554 for drinking house and field ditch water (95% CI 1.961 - 6.584), and 3.121 for drinking pond water (95% CI 1.872 - 6.566).	Water	60-65	nuclear RNA export factor 1	Homo sapiens	28-31
25958631-9	2015	When compared with drinking tap water, OR for drinking well water was 1.770 (95% CI 1.001 - 2.444), 2.442 for drinking river water (95% CI 0.956 - 3.950), 2.554 for drinking house and field ditch water (95% CI 1.961 - 6.584), and 3.121 for drinking pond water (95% CI 1.872 - 6.566).	Water	60-65	nuclear RNA export factor 1	Homo sapiens	28-31
25958631-9	2015	When compared with drinking tap water, OR for drinking well water was 1.770 (95% CI 1.001 - 2.444), 2.442 for drinking river water (95% CI 0.956 - 3.950), 2.554 for drinking house and field ditch water (95% CI 1.961 - 6.584), and 3.121 for drinking pond water (95% CI 1.872 - 6.566).	Water	60-65	nuclear RNA export factor 1	Homo sapiens	28-31
27646620-3	2015	METHODS: In two retrospective case-control studies, the association between gastroenteritis of etiologically unspecified origin or Salmonellosis and food from a restaurant or drinking tap water were tested by univariate and multivariate analysis.	Water	188-193	nuclear RNA export factor 1	Homo sapiens	184-187
27646620-7	2015	A resident exposed to tap water from specific water source had a 3.4 times higher odds ratio (univariate analysis of OR 3.4, 95% CI 2.2 to 5.1 is p &lt;0.05, multivariate analysis of RO 2.9, 95% CI 1, 7 to 5.3, p &lt;0.05), for gastroenteritis of unspecific etiology than non-exposed.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
27646620-7	2015	A resident exposed to tap water from specific water source had a 3.4 times higher odds ratio (univariate analysis of OR 3.4, 95% CI 2.2 to 5.1 is p &lt;0.05, multivariate analysis of RO 2.9, 95% CI 1, 7 to 5.3, p &lt;0.05), for gastroenteritis of unspecific etiology than non-exposed.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	22-25
27646620-9	2015	CONCLUSION: Analytical cases - controls studies confirmed a causal relationship between salmonellosis and food from the specific restaurant and the causal relationship between gastroenteritis of etiologically unspecified origin and drinking tap water from specific water source.	Water	245-250	nuclear RNA export factor 1	Homo sapiens	241-244
25489068-4	2014	The magic H3O(+)(H2O)20 cluster yields particularly clear spectral signatures that can, with the aid of ab initio predictions, be traced to specific classes of network sites in the predicted pentagonal dodecahedron H-bonded cage with the hydronium ion residing on the surface.	Water	17-20	H3 clustered histone 15	Homo sapiens	10-13
25440663-8	2014	The nanographene-based sensor was also demonstrated to be a promising and reliable tool for the rapid detection of cadmium existing in tap water and for the rapid on-site analysis of critical pollution levels of cadmium.	Water	139-144	nuclear RNA export factor 1	Homo sapiens	135-138
25150048-1	2014	Aquaporin-4 (AQP4) is the predominant water channel in different organs and tissues.	Water	38-43	aquaporin 4	Homo sapiens	0-11
25150048-1	2014	Aquaporin-4 (AQP4) is the predominant water channel in different organs and tissues.	Water	38-43	aquaporin 4	Homo sapiens	13-17
25150048-10	2014	Our results are in agreement with recent experimental observations and may represent a promising starting point to pave the way for the discovery of chemical modulators of AQP4 water permeability.	Water	177-182	aquaporin 4	Homo sapiens	172-176
24405389-4	2014	We aimed to investigate the efficacy and reliability of tap water iontophoresis in children with primary hyperhidrosis.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
24405389-6	2014	In our clinic, tap water iontophoresis was administered at regular intervals, starting with five times per week and decreased to once a week on fifth week.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
24405389-16	2014	CONCLUSION: Tap water iontophoresis is an effective method of treatment for primary palmoplantar and axillary hyperhidrosis in paediatric patients.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
25323950-4	2014	The SCRT water extract demonstrated a dose-dependent inhibition of RANTES, eotaxin, eotaxin-3 and matrix metalloproteinase-9 (MMP-9) in BEAS-2B cells.	Water	9-14	C-C motif chemokine ligand 5	Homo sapiens	67-73
25323950-4	2014	The SCRT water extract demonstrated a dose-dependent inhibition of RANTES, eotaxin, eotaxin-3 and matrix metalloproteinase-9 (MMP-9) in BEAS-2B cells.	Water	9-14	C-C motif chemokine ligand 26	Homo sapiens	84-93
25323950-4	2014	The SCRT water extract demonstrated a dose-dependent inhibition of RANTES, eotaxin, eotaxin-3 and matrix metalloproteinase-9 (MMP-9) in BEAS-2B cells.	Water	9-14	matrix metallopeptidase 9	Homo sapiens	98-124
25323950-4	2014	The SCRT water extract demonstrated a dose-dependent inhibition of RANTES, eotaxin, eotaxin-3 and matrix metalloproteinase-9 (MMP-9) in BEAS-2B cells.	Water	9-14	matrix metallopeptidase 9	Homo sapiens	126-131
25082552-1	2014	Recent studies on cerebrospinal fluid (CSF) homeostasis emphasize the importance of water influx into the peri-capillary (Virchow-Robin) space through aquaporin 4 (AQP-4).	Water	84-89	aquaporin 4	Mus musculus	164-169
25082552-5	2014	The study strongly indicates that disturbance in AQP-4-based water flow and, hence, impairment in beta-amyloid clearance play a significant role in SP formation.	Water	61-66	aquaporin 4	Mus musculus	49-54
25710978-0	2014	[Report on tap water quality in France ].	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
25337794-1	2014	The fundamental structure of an isolated water dimer on Pt(111) was determined by means of a spectroscopic method using scanning tunneling microscopy (STM) and density functional theory (DFT) calculations.	Water	41-46	sulfotransferase family 1A member 3	Homo sapiens	151-154
25337794-2	2014	Two water molecules on adjacent atop sites form a dimer through a hydrogen bond, and they rotate even at a substrate temperature of 5 K. Action spectroscopy using STM (STM-AS) for water dimer hopping allows us to obtain the vibrational spectrum of a single water dimer on Pt(111).	Water	4-9	sulfotransferase family 1A member 3	Homo sapiens	163-166
25337794-2	2014	Two water molecules on adjacent atop sites form a dimer through a hydrogen bond, and they rotate even at a substrate temperature of 5 K. Action spectroscopy using STM (STM-AS) for water dimer hopping allows us to obtain the vibrational spectrum of a single water dimer on Pt(111).	Water	4-9	sulfotransferase family 1A member 3	Homo sapiens	168-174
25337794-2	2014	Two water molecules on adjacent atop sites form a dimer through a hydrogen bond, and they rotate even at a substrate temperature of 5 K. Action spectroscopy using STM (STM-AS) for water dimer hopping allows us to obtain the vibrational spectrum of a single water dimer on Pt(111).	Water	180-185	sulfotransferase family 1A member 3	Homo sapiens	163-166
25337794-2	2014	Two water molecules on adjacent atop sites form a dimer through a hydrogen bond, and they rotate even at a substrate temperature of 5 K. Action spectroscopy using STM (STM-AS) for water dimer hopping allows us to obtain the vibrational spectrum of a single water dimer on Pt(111).	Water	180-185	sulfotransferase family 1A member 3	Homo sapiens	168-174
25337794-2	2014	Two water molecules on adjacent atop sites form a dimer through a hydrogen bond, and they rotate even at a substrate temperature of 5 K. Action spectroscopy using STM (STM-AS) for water dimer hopping allows us to obtain the vibrational spectrum of a single water dimer on Pt(111).	Water	180-185	sulfotransferase family 1A member 3	Homo sapiens	163-166
25337794-2	2014	Two water molecules on adjacent atop sites form a dimer through a hydrogen bond, and they rotate even at a substrate temperature of 5 K. Action spectroscopy using STM (STM-AS) for water dimer hopping allows us to obtain the vibrational spectrum of a single water dimer on Pt(111).	Water	180-185	sulfotransferase family 1A member 3	Homo sapiens	168-174
25426721-2	2014	Their increased uptake, predominantly provided by astrocytes, is associated with water influx via aquaporin-4 (AQP4).	Water	81-86	aquaporin 4	Mus musculus	98-109
25426721-2	2014	Their increased uptake, predominantly provided by astrocytes, is associated with water influx via aquaporin-4 (AQP4).	Water	81-86	aquaporin 4	Mus musculus	111-115
25412499-11	2014	However, analyses of spiked tap water samples revealed a high correlation (R(2) = 0.863) between results from EMA-qPCR and the reference method.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
24874657-1	2014	Aquaporin-4 (AQP4) water channel protein transports water molecules across cell membranes bidirectionally and involves in a neurological disorder, neuromyelitis optica (NMO) caused by anti-AQP4 antibodies.	Water	19-24	aquaporin 4	Homo sapiens	0-11
24874657-1	2014	Aquaporin-4 (AQP4) water channel protein transports water molecules across cell membranes bidirectionally and involves in a neurological disorder, neuromyelitis optica (NMO) caused by anti-AQP4 antibodies.	Water	19-24	aquaporin 4	Homo sapiens	13-17
24874657-1	2014	Aquaporin-4 (AQP4) water channel protein transports water molecules across cell membranes bidirectionally and involves in a neurological disorder, neuromyelitis optica (NMO) caused by anti-AQP4 antibodies.	Water	19-24	aquaporin 4	Homo sapiens	189-193
24874657-1	2014	Aquaporin-4 (AQP4) water channel protein transports water molecules across cell membranes bidirectionally and involves in a neurological disorder, neuromyelitis optica (NMO) caused by anti-AQP4 antibodies.	Water	52-57	aquaporin 4	Homo sapiens	0-11
24874657-1	2014	Aquaporin-4 (AQP4) water channel protein transports water molecules across cell membranes bidirectionally and involves in a neurological disorder, neuromyelitis optica (NMO) caused by anti-AQP4 antibodies.	Water	52-57	aquaporin 4	Homo sapiens	13-17
24874657-1	2014	Aquaporin-4 (AQP4) water channel protein transports water molecules across cell membranes bidirectionally and involves in a neurological disorder, neuromyelitis optica (NMO) caused by anti-AQP4 antibodies.	Water	52-57	aquaporin 4	Homo sapiens	189-193
24912716-0	2014	Effect of water content and temperature on inactivation kinetics of myrosinase in broccoli (Brassica oleracea var.	Water	10-15	myrosinase	Brassica oleracea	68-78
25200497-1	2014	BACKGROUNDS AND AIMS: UDP-glucuronosyltransferase 1 A1 (UGT1A1) is an enzyme that transforms small lipophilic molecules into water-soluble and excretable metabolites.	Water	125-130	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	22-54
25200497-1	2014	BACKGROUNDS AND AIMS: UDP-glucuronosyltransferase 1 A1 (UGT1A1) is an enzyme that transforms small lipophilic molecules into water-soluble and excretable metabolites.	Water	125-130	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	56-62
25404872-8	2014	SAR values were determined after the suspension of MNP in water.	Water	58-63	sarcosine dehydrogenase	Homo sapiens	0-3
25281266-5	2014	Our results provide critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain, and reveal that ordered water molecules are an essential component driving ligand recognition.	Water	135-140	bromodomain and PHD finger containing 1	Homo sapiens	92-97
25759346-8	2014	RESULTS: Air contamination by Legionella was found in three healthcare facilities (one with active and two with passive sampling), showing a concomitant tap water contamination (median=40,000; range 1,100-43,000 cfu/l).	Water	157-162	nuclear RNA export factor 1	Homo sapiens	153-156
25259750-9	2014	In response to a sodium/volume challenge, wild-type and CD4(-/-) mice infused with angiotensin II retained water and sodium, whereas CD8(-/-) mice did not.	Water	107-112	CD4 antigen	Mus musculus	56-59
25189192-2	2014	The dispersibility of the PIL-functionalized CNFs in water and various organic solvents could be tuned by the choice of the PIL-binding anion.	Water	53-58	serpin family A member 2 (gene/pseudogene)	Homo sapiens	26-29
25189192-2	2014	The dispersibility of the PIL-functionalized CNFs in water and various organic solvents could be tuned by the choice of the PIL-binding anion.	Water	53-58	serpin family A member 2 (gene/pseudogene)	Homo sapiens	124-127
25265491-1	2014	Sodium reabsorption via Na-K-2Cl cotransporter 2 (NKCC2) in the thick ascending limbs has a major role for medullary osmotic gradient and subsequent water reabsorption in the collecting ducts.	Water	149-154	solute carrier family 12 member 1	Rattus norvegicus	24-48
25265491-1	2014	Sodium reabsorption via Na-K-2Cl cotransporter 2 (NKCC2) in the thick ascending limbs has a major role for medullary osmotic gradient and subsequent water reabsorption in the collecting ducts.	Water	149-154	solute carrier family 12 member 1	Rattus norvegicus	50-55
24979063-5	2014	Analysis of the water adsorption geometry and energetics shows that the relative stability of water adsorption on SnO2(110) is governed largely by the strength of the chemisorption and hydrogen bonds at the surface of the adsorbate-substrate system.	Water	16-21	strawberry notch homolog 2	Homo sapiens	114-117
24979063-5	2014	Analysis of the water adsorption geometry and energetics shows that the relative stability of water adsorption on SnO2(110) is governed largely by the strength of the chemisorption and hydrogen bonds at the surface of the adsorbate-substrate system.	Water	94-99	strawberry notch homolog 2	Homo sapiens	114-117
26300567-1	2014	Solar-light-driven H2 production in water with a [NiFeSe]-hydrogenase (H2ase) and a bioinspired synthetic nickel catalyst (NiP) in combination with a heptazine carbon nitride polymer, melon (CNx), is reported.	Water	36-41	relaxin 2	Homo sapiens	19-21
25058931-0	2014	Water exposure assessment of aryl hydrocarbon receptor agonists in Three Gorges Reservoir, China using SPMD-based virtual organisms.	Water	0-5	aryl hydrocarbon receptor	Rattus norvegicus	29-54
25058931-2	2014	The water exposure of aryl hydrocarbon receptor (AhR) agonists was assessed by the VOs.	Water	4-9	aryl hydrocarbon receptor	Rattus norvegicus	22-47
25058931-2	2014	The water exposure of aryl hydrocarbon receptor (AhR) agonists was assessed by the VOs.	Water	4-9	aryl hydrocarbon receptor	Rattus norvegicus	49-52
25226398-1	2014	We report that water-in-ionic liquid microemulsions (MEs) are stably formed in an organic solvent-free system, i.e., a mixture of aprotic (aIL) and protic (pIL) imidazolium-based ionic liquids (ILs) containing the anionic surfactant dioctyl sulfosuccinate sodium salt (AOT).	Water	15-20	serpin family A member 2 (gene/pseudogene)	Homo sapiens	156-159
25246550-7	2014	We suggest that Asp21 and His84 provide a network of interactions that stabilize the positions of the gamma-phosphate and the nucleophilic water, respectively, and thus play an indirect catalytic role in the GTPase mechanism on the ribosome.	Water	139-144	beta-secretase 2	Homo sapiens	16-21
25070104-7	2014	We propose, supported by simulated models of PER-2 in combination with different beta-lactams, the presence of a hydrogen-bond network connecting Ser70-Gln69-water-Thr237-Arg220 that might be important for the proper activity and inhibition of the enzyme.	Water	158-163	period circadian regulator 2	Homo sapiens	45-50
24806323-4	2014	Aquaporin (AQP) 5 is the chief AQP in the lungs and it plays a key role in many processes, including water transport in normal and abnormal lungs.	Water	101-106	aquaporin 5	Rattus norvegicus	11-17
25012143-7	2014	Tap water samples collected from three towns (North Wales, the English Midlands, and South East England) supplied uniquely by upland reservoir water, river water, and Chalk groundwater, respectively, also showed a remarkable uniformity in Mo concentrations at each location.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
25012143-8	2014	Within each, the variability was very small between houses (old and new), between pre-flush and post-flush samples, and between the tap water and respective source water samples.	Water	136-141	nuclear RNA export factor 1	Homo sapiens	132-135
25012143-10	2014	The findings contrast with those for Cu, Zn, Ni, Pb, and Cd, which showed significant differences (p &lt; 0.05) in concentrations between pre-flush and post-flush tap water samples.	Water	167-172	nuclear RNA export factor 1	Homo sapiens	163-166
25017970-4	2014	in the priming phase, but not in the effector phase, of immune response of EAU enhanced disease scores and its related immune responses including DTH, Ag-specific T cell proliferation and the production of IL-17 and IFN-gamma.	Water	75-78	interleukin 17A	Mus musculus	206-211
25672190-13	2014	Logistic regression was done and uncovered water containers (p-value &lt;0.05) to (adjusted OR=1.8; p-=0.008), surrounding marshy land (p=0.03) to (adjusted OR=1.75; p=0.02) &amp; tap water (p=0.001) to (adjusted OR=3.2964; p=0.0012) were found to be associated with the fever.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	180-183
25308589-0	2014	Comparison of individuals consuming natural spring water and tap water in terms of urinary tract stone disease.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
25308589-1	2014	OBJECTIVES: To compare individuals consuming natural spring water and tap water in terms of presence of urinary tract stone disease.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
25096474-1	2014	We use (2)H NMR to study the rotational motion of supercooled water in silica pores of various diameters, specifically, in the MCM-41 materials C10, C12, and C14.	Water	62-67	chromosome 12 open reading frame 57	Homo sapiens	144-147
25096474-7	2014	In the high-temperature range, T &gt; 225 K, the temperature dependence of water reorientation is weaker in the smaller C10 pores than in the larger C12 and C14 pores, where it is more bulk-like, indicating a significant effect of the silica confinement on the alpha process of water in the former 2.1 nm confinement.	Water	75-80	chromosome 12 open reading frame 57	Homo sapiens	120-123
25096474-7	2014	In the high-temperature range, T &gt; 225 K, the temperature dependence of water reorientation is weaker in the smaller C10 pores than in the larger C12 and C14 pores, where it is more bulk-like, indicating a significant effect of the silica confinement on the alpha process of water in the former 2.1 nm confinement.	Water	278-283	chromosome 12 open reading frame 57	Homo sapiens	120-123
25171328-3	2014	On the basis of the above observation, we conclude that the environmental adsorbates work by more than simply shifting the Fermi level of the CNTs; more importantly, these adsorbates cause a poor gate modulation efficiency of electron conduction due to the relatively large trap state density near the conduction band edge of the carbon nanotubes, for which we further propose quantitatively that the adsorbed oxygen-water redox couple is responsible.	Water	417-422	TRAP	Homo sapiens	274-278
25166739-2	2014	Studies of rhodopsin, a prototype GPCR, have suggested that water plays an important role in mediating the activation of family A GPCRs.	Water	60-65	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	34-38
25166739-3	2014	However, our understanding of the function of water molecules in the GPCR activation is still rather limited because resolving the functional water molecules solely based on the results from existing experiments is challenging.	Water	46-51	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	69-73
25166739-3	2014	However, our understanding of the function of water molecules in the GPCR activation is still rather limited because resolving the functional water molecules solely based on the results from existing experiments is challenging.	Water	142-147	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	69-73
25228547-6	2014	Proangiogenic effects of IL-17 on CECs was determined by proliferation assays with a water-soluble tetrazolium cell proliferation reagent kit, wound healing migration assays, and tube formation assays using basement membrane matrix.	Water	85-90	interleukin 17A	Homo sapiens	25-30
25179107-2	2014	The limiting factor for microbial re-growth in a tap water produced by a conventional drinking water treatment plant in China was identified by determining the microbial re-growth potential (MRP) by adding different nutrients to stimulate growth of a natural microbial consortium as inoculum and flow-cytometric enumeration.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
25179107-4	2014	This clearly demonstrated that microbial re-growth in this tap water was limited by P. Most of the re-grown microbial flora (&gt;85%) consisted of high nucleic acid content cells.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
25124666-2	2014	The rapid water flux through AQP4 may contribute to electrolyte/water homeostasis and may support neuronal activities in the CNS.	Water	10-15	aquaporin 4	Mus musculus	29-33
25124666-2	2014	The rapid water flux through AQP4 may contribute to electrolyte/water homeostasis and may support neuronal activities in the CNS.	Water	64-69	aquaporin 4	Mus musculus	29-33
24908641-2	2014	The occurrence of these compounds in tap water in this region is also investigated and a preliminary human health risk characterization performed for those substances found in tap water.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
24908641-2	2014	The occurrence of these compounds in tap water in this region is also investigated and a preliminary human health risk characterization performed for those substances found in tap water.	Water	180-185	nuclear RNA export factor 1	Homo sapiens	176-179
24908641-10	2014	Two out of the nineteen compounds studied, namely cocaine (CO) and EPH, were detected in tap water from one sampling point at concentrations of 1.61 and 0.29ngL(-1), respectively.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
24908641-11	2014	The preliminary human health risk characterization showed that no toxic effects could be expected at the detected concentration level in tap water.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	137-140
24888323-1	2014	OBJECTIVE: This study was conducted to evaluate the effect of the synthetic water-soluble phenolic antioxidant TS-13 (sodium 3-(4"-methoxyphenyl)propyl thiosulfonate), an inducer of the redox-dependent Keap1/Nrf2/ARE signaling system, in experimental models of acute and chronic inflammation.	Water	76-81	Kelch-like ECH-associated protein 1	Rattus norvegicus	202-207
25080314-8	2014	According to the results, ghrelin injection reduced food and water intake by broiler cockerels (p&lt;=0.05).	Water	61-66	ghrelin/obestatin prepropeptide	Gallus gallus	26-33
25147923-8	2014	Drinking untreated tap water from the defined outbreak area was significantly associated with illness (RR 5.6, 95% CI 1.9-16.4) increasing in a dose response manner.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
25147923-11	2014	Microbial community sequencing of contaminated tap water revealed abundance of Arcobacter species.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
24962153-0	2014	Ligand induced change of beta2 adrenergic receptor from active to inactive conformation and its implication for the closed/open state of the water channel: insight from molecular dynamics simulation, free energy calculation and Markov state model analysis.	Water	141-146	adrenoceptor beta 2	Homo sapiens	25-50
24962153-1	2014	The reported crystal structures of beta2 adrenergic receptor (beta2AR) reveal that the open and closed states of the water channel are correlated with the inactive and active conformations of beta2AR.	Water	117-122	adrenoceptor beta 2	Homo sapiens	35-60
24962153-1	2014	The reported crystal structures of beta2 adrenergic receptor (beta2AR) reveal that the open and closed states of the water channel are correlated with the inactive and active conformations of beta2AR.	Water	117-122	adrenoceptor beta 2	Homo sapiens	62-69
24962153-1	2014	The reported crystal structures of beta2 adrenergic receptor (beta2AR) reveal that the open and closed states of the water channel are correlated with the inactive and active conformations of beta2AR.	Water	117-122	adrenoceptor beta 2	Homo sapiens	192-199
24962153-2	2014	However, more details about the process by which the water channel states are affected by the active to inactive conformational change of beta2AR remain illusive.	Water	53-58	adrenoceptor beta 2	Homo sapiens	138-145
24962153-5	2014	The simulation results show that inverse agonist ICI 118,551 can induce water channel opening during the conformational transition of beta2AR.	Water	72-77	adrenoceptor beta 2	Homo sapiens	134-141
24962153-7	2014	States S1, S2 and S5, which represent the active conformation of beta2AR, show that the water channel is in the closed state, while states S4 and S6, which correspond to the intermediate state conformation of beta2AR, indicate the water channel opens gradually.	Water	88-93	adrenoceptor beta 2	Homo sapiens	65-72
24962153-7	2014	States S1, S2 and S5, which represent the active conformation of beta2AR, show that the water channel is in the closed state, while states S4 and S6, which correspond to the intermediate state conformation of beta2AR, indicate the water channel opens gradually.	Water	88-93	adrenoceptor beta 2	Homo sapiens	209-216
24962153-7	2014	States S1, S2 and S5, which represent the active conformation of beta2AR, show that the water channel is in the closed state, while states S4 and S6, which correspond to the intermediate state conformation of beta2AR, indicate the water channel opens gradually.	Water	231-236	adrenoceptor beta 2	Homo sapiens	65-72
24962153-8	2014	State S7, which represents the inactive structure of beta2AR, corresponds to the full open state of the water channel.	Water	104-109	adrenoceptor beta 2	Homo sapiens	53-60
24962153-9	2014	The opening mechanism of the water channel is involved in the ligand-induced conformational change of beta2AR.	Water	29-34	adrenoceptor beta 2	Homo sapiens	102-109
25101829-3	2014	In this study, we found that the cortical and hippocampal expression of neuritin is reduced in the brains of Alzheimer"s disease (AD) patients and demonstrated that viral-mediated expression of neuritin in the dentate gyrus of 13-month-old Tg2576 mice, an AD animal model, attenuated a deficit in learning and memory as assessed by a Morris water maze test.	Water	341-346	neuritin 1	Homo sapiens	72-80
25101829-3	2014	In this study, we found that the cortical and hippocampal expression of neuritin is reduced in the brains of Alzheimer"s disease (AD) patients and demonstrated that viral-mediated expression of neuritin in the dentate gyrus of 13-month-old Tg2576 mice, an AD animal model, attenuated a deficit in learning and memory as assessed by a Morris water maze test.	Water	341-346	neuritin 1	Homo sapiens	194-202
24894646-5	2014	The trends of characteristic protein expression, including that of nestin, vimentin, GFAP and glutamine synthetase, for astrocytes cultured on super water-repellent fractal PPP surfaces approximate more to in vivo pattern.	Water	149-154	glial fibrillary acidic protein	Homo sapiens	85-89
24617572-4	2014	METHODS: In skin soak tests, 5% detergent solutions were applied to the forearms of 10 Japanese healthy volunteers for 30 min followed by washing with tap water once a day for 4 days.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	151-154
24915007-1	2014	The main water channel in the brain, aquaporin-4 (AQP4) is involved in maintaining homeostasis and water exchange in the brain.	Water	9-14	aquaporin 4	Mus musculus	37-48
24915007-1	2014	The main water channel in the brain, aquaporin-4 (AQP4) is involved in maintaining homeostasis and water exchange in the brain.	Water	9-14	aquaporin 4	Mus musculus	50-54
24915007-1	2014	The main water channel in the brain, aquaporin-4 (AQP4) is involved in maintaining homeostasis and water exchange in the brain.	Water	99-104	aquaporin 4	Mus musculus	37-48
24915007-1	2014	The main water channel in the brain, aquaporin-4 (AQP4) is involved in maintaining homeostasis and water exchange in the brain.	Water	99-104	aquaporin 4	Mus musculus	50-54
25202204-1	2014	[Purpose] The purpose of this study was to evaluate the efficacy of tap water (drinking water) and normal saline (sodium chloride solution 0.9%) iontophoresis treatment for a patient with idiopathic hyperhidrosis [Subjects and Methods] In this study, tap water and normal saline iontophoresis were used to treat a 21 year-old female who was suffering from severe palmoplantar idiopathic hyperhidrosis.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
25202204-3	2014	[Results] The subject showed 24.72% and 42.01% decreases in sweat intensity following tap water and normal saline iontophoresis, respectively.	Water	90-95	nuclear RNA export factor 1	Homo sapiens	86-89
25202204-4	2014	[Conclusion] Tap water and normal saline iontophoresis are effective in the treatment of idiopathic hyperhidrosis.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
24962087-3	2014	Taking advantage of hydrophobic interactions and self-recognition properties of the BTA units, the "free" BTAs are captured into the interior of the SCPN in water as evidenced by fluorescence studies.	Water	157-162	carboxypeptidase N subunit 1	Homo sapiens	149-153
24962087-4	2014	To illustrate that function can be readily introduced using a modular approach, l-proline-based BTAs are incorporated to procure a catalytically active SCPN in water.	Water	160-165	carboxypeptidase N subunit 1	Homo sapiens	152-156
24992468-1	2014	Ricin, a large, water soluble toxic glycoprotein, is distributed majorly in the kernels of castor beans (the seeds of Ricinus communis L.) and has been used in traditional Chinese medicine (TCM) or other folk remedies throughout the world.	Water	16-21	ricin	Ricinus communis	0-5
24751343-6	2014	The water contact angle (WCA) test also noted the differences of these two fibers: PCL/PEG core/sheath fibers with cross-linked PEG surface exhibited more hydrophilic property.	Water	4-9	PHD finger protein 1	Homo sapiens	83-90
24942877-0	2014	The grapevine tonoplast aquaporin TIP2;1 is a pressure gated water channel.	Water	61-66	aquaporin TIP2-1	Vitis vinifera	34-40
24517192-3	2014	The interfacial free energy of the fused silica/water interface calculated from the Lippmann equation is reduced by a factor of 7 in the presence of single-layer pristine graphene, while defected graphene reduces it only by a factor of at most 2.	Water	48-53	GSN antisense RNA 1	Homo sapiens	239-245
24635833-2	2014	Vasopressin-1a receptors (V1aR) and aquaporin-4 (AQP4) regulate water transport and brain edema formation, perhaps in part by modulating cation fluxes.	Water	64-69	arginine vasopressin receptor 1A	Rattus norvegicus	0-24
24635833-2	2014	Vasopressin-1a receptors (V1aR) and aquaporin-4 (AQP4) regulate water transport and brain edema formation, perhaps in part by modulating cation fluxes.	Water	64-69	arginine vasopressin receptor 1A	Rattus norvegicus	26-30
24884609-5	2014	First, we confirmed that the four ITIH4 N-X-S/T sequons (N81, N207, N517, and N577) were glycosylated by treating ITIH4 tryptic/GluC glycopeptides with PNGaseF in the presence of (18)O water.	Water	185-190	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	128-132
24325682-2	2014	The specific constitution of this protein and its selective permeability to water means that AQP2 plays an important role in hypertonic urine production.	Water	76-81	aquaporin 2	Bos taurus	93-97
24726966-10	2014	The tap water production is identified as the most influential process due to its high embodied energy demand in a local context.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
26563079-4	2014	Based on SAR, RSC, US Salinity diagram and Wilcox diagram it is observed that the water ranges from excellent to good quality in most of the places and can be used for irrigation without any hazard.	Water	82-87	sarcosine dehydrogenase	Homo sapiens	9-12
25038507-11	2014	Incorporation of an ordered water molecule in PTP1B screening was also found to generally improve enrichment.	Water	28-33	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	46-51
24697809-1	2014	OBJECTIVES: The objective of this study was to improve the water solubility and solubility of glaucocalyxin A (GLA) by producing its inclusion complex with sulfobutylether-beta-cyclodextrin (SBE-beta-CD).	Water	59-64	galactosidase alpha	Homo sapiens	94-109
24697809-1	2014	OBJECTIVES: The objective of this study was to improve the water solubility and solubility of glaucocalyxin A (GLA) by producing its inclusion complex with sulfobutylether-beta-cyclodextrin (SBE-beta-CD).	Water	59-64	galactosidase alpha	Homo sapiens	111-114
24798037-0	2014	The protective effect of apelin against water-immersion and restraint stress-induced gastric damage.	Water	40-45	apelin	Rattus norvegicus	25-31
24798037-1	2014	The aim of the present study was to investigate the gastroprotective effect of apelin on water-immersion and restraint stress (WIRS)-induced gastric lesions.	Water	89-94	apelin	Rattus norvegicus	79-85
24522493-2	2014	Loss of V2R function prevents plasma membrane expression of the AQP2 water channel in the kidney collecting duct cells and impairs the kidney concentration ability.	Water	69-74	arginine vasopressin receptor 2	Mus musculus	8-11
24984066-0	2014	Deep-sea water containing selenium provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase 1.	Water	9-14	thioredoxin reductase 1	Rattus norvegicus	128-151
24984066-8	2014	Drinking DSW600, DSW1200, and selenium water but not Mg2+ water significantly enhanced Bcl-2 and thioredoxin reductase 1 expression.	Water	39-44	thioredoxin reductase 1	Rattus norvegicus	97-120
24927535-3	2014	We demonstrate that ethanol docks onto a water-accessible site that is strategically positioned between the slo1 calcium-sensors and gate.	Water	41-46	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	108-112
24727276-0	2014	hypD as a marker for [NiFe]-hydrogenases in microbial communities of surface waters.	Water	77-83	MAGE family member A3	Homo sapiens	0-4
24418072-4	2014	The binding affinity calculations by WaterMap provided over one hundred hydration sites in the MDM2 binding pocket where water density is greater than twice that of the bulk, and the relative value of free energy released by displacing these hydration sites.	Water	121-126	MDM2 proto-oncogene	Homo sapiens	95-99
24713172-6	2014	Application to buildup curves from (2)H2O hydrated elastin, which has an unresolved coupling, revealed a large increase in the 2Q signal upon mechanical stretch that is due to an increase in the ordered water fraction while changes in the residual coupling and T2 are small.	Water	38-41	elastin	Homo sapiens	51-58
24713172-6	2014	Application to buildup curves from (2)H2O hydrated elastin, which has an unresolved coupling, revealed a large increase in the 2Q signal upon mechanical stretch that is due to an increase in the ordered water fraction while changes in the residual coupling and T2 are small.	Water	203-208	elastin	Homo sapiens	51-58
24590923-11	2014	Water deprivation increased plasma sodium and diuresis but decreased AQP-2 (46 +- 22 vs 112 +- 25;  p &lt; 0.05) and eNOS expression in the kidney.	Water	0-5	nitric oxide synthase 3	Rattus norvegicus	117-121
24368741-3	2014	Aquaporin 4 (AQP4) is a water-selective membrane transport protein, and its knockout could alter retinal neuron excitability.	Water	24-29	aquaporin 4	Mus musculus	0-11
24368741-3	2014	Aquaporin 4 (AQP4) is a water-selective membrane transport protein, and its knockout could alter retinal neuron excitability.	Water	24-29	aquaporin 4	Mus musculus	13-17
25206775-5	2014	These results suggest that matrix metalloproteinase-9 upregulation is associated with increased regional angiogenesis and degradation of collagen IV, the major component of the basal lamina, in stroke-prone spontaneously hypertensive rats with high-sodium water-induced focal cerebral infarction.	Water	256-261	matrix metallopeptidase 9	Rattus norvegicus	27-53
25141315-3	2014	Warm tap water was administered via a rectal tube to the patients in prone position.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	5-8
24832996-1	2014	In the EU Water Framework Directive (WFD) six PBDE congeners (BDE 28, BDE47, BDE 99, BDE 100, BDE 153 and BDE 154) are listed as priority substances.	Water	10-15	homeobox D13	Homo sapiens	47-50
24708946-3	2014	Water adsorption isotherms type II were fitted by the GAB model and the water monolayer content was determined for each system.	Water	0-5	alpha-1-B glycoprotein	Homo sapiens	54-57
24730513-5	2014	On the other hand, the multiplicative method outperformed the Bayesian method if actual tap water consumption rates were systematically overestimated.	Water	92-97	nuclear RNA export factor 1	Homo sapiens	88-91
24730513-6	2014	If tap water consumption rates gradually decreased over time because of substitution with bottled water or other liquids, neither method clearly outperformed another.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
24631962-6	2014	RESULTS: CSP, prepared by hot water extraction, ethanol precipitation and membrane dialysis, was found to be composed of three glycoproteins with average molecular weights of 543, 31, and 6.3 kDa, respectively.	Water	30-35	DnaJ heat shock protein family (Hsp40) member C5	Rattus norvegicus	9-12
24666204-3	2014	These autoantibodies were later shown to target aquaporin-4 (AQP4), the most abundant water channel in the central nervous system (CNS).	Water	86-91	aquaporin 4	Homo sapiens	48-59
24422972-1	2014	AIMS: The predominant expression of aquaporin-4 (AQP4) in the brain implies that this water channel may be involved in a range of brain disorders.	Water	86-91	aquaporin 4	Mus musculus	36-47
24422972-1	2014	AIMS: The predominant expression of aquaporin-4 (AQP4) in the brain implies that this water channel may be involved in a range of brain disorders.	Water	86-91	aquaporin 4	Mus musculus	49-53
24525453-10	2014	In adjusted models, every log 10 increase in maternal drinking water arsenic exposure was estimated to increase CD8+ T cells by 7.4% (P = 0.0004) and decrease in CD4+ T cells by 9.2% (P = 0.0002).	Water	63-68	CD8a molecule	Homo sapiens	112-115
24360431-7	2014	This epimerisation may take place more readily in tap water than in distilled water owing to the complexity of the ions present in tap water.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
24360431-7	2014	This epimerisation may take place more readily in tap water than in distilled water owing to the complexity of the ions present in tap water.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	131-134
24360431-7	2014	This epimerisation may take place more readily in tap water than in distilled water owing to the complexity of the ions present in tap water.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	131-134
24360431-7	2014	This epimerisation may take place more readily in tap water than in distilled water owing to the complexity of the ions present in tap water.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	131-134
24387938-0	2014	[Fluoride content in tap water in Spain and prevention of dental caries].	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
24522335-6	2014	These findings suggest that METH may increase BBB permeability by altering CLDN5 and MMP9, and the self-protective system maybe activated to eliminate accumulating water from the extracellular space of the brain by up-regulating AQP4.	Water	164-169	aquaporin 4	Homo sapiens	229-233
24657390-6	2014	Our results show that due to fast exchange of amide protons with water in the soluble heme-containing domain of cyb5, coherent (1)H-(1)H dipolar interactions are averaged out for these protons while alpha and side chain protons show residual dipolar couplings that can be obtained from (1)H-(1)H RFDR experiments.	Water	65-70	cytochrome b5	Oryctolagus cuniculus	112-116
24593923-3	2014	Although not statistically significant after correcting for multiple testing, nine SNPs in APOE, AS3MT, PNP, and TNF genes had a nominally statistically significant interaction with well-water arsenic in cIMT.	Water	187-192	arsenite methyltransferase	Homo sapiens	97-102
24568732-8	2014	In addition, VPA decreased escape latencies of Tg6799 mice at 5 and 10months of age in Morris water maze assessment.	Water	94-99	renin binding protein	Mus musculus	80-83
24657265-11	2014	The full enlightenment of this particular relation between CFTR and AQP4 may point towards possible therapeutic targets to counteract male subfertility/infertility in men with Cystic Fibrosis and mutations in CFTR gene, which are known to impair spermatogenesis due to defective water transport.	Water	279-284	aquaporin 4	Homo sapiens	68-72
25007631-2	2014	Utilizing the strong quenching effect of Hg2+ to the phosphorescence of the ZnS: Mn quantum dots, the method to detect micro-quantity Hg2+ in water was established by using the quantum dots as the phosphorescence probes.	Water	142-147	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	41-44
25007631-2	2014	Utilizing the strong quenching effect of Hg2+ to the phosphorescence of the ZnS: Mn quantum dots, the method to detect micro-quantity Hg2+ in water was established by using the quantum dots as the phosphorescence probes.	Water	142-147	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	134-137
24667701-2	2014	The results showed that the median total N concentrations of still surface water were significantly higher in the agro- (1.5 mg   L(-1)) and oasis agro- ecosystems (1.8 mg   L(-1)) than in the forest ecosystems (1.0 mg   L(-1)).	Water	75-80	cAMP responsive element binding protein 3 like 1	Homo sapiens	141-146
24667701-3	2014	This was also the case for flowing surface water, with total N concentrations of 2.4 mg   L(-1), 1.8 mg   L(-1) and 0.5 mg   L(-1) for the agro-, oasis agro- and forest ecosystems, respectively.	Water	43-48	cAMP responsive element binding protein 3 like 1	Homo sapiens	146-151
24655190-9	2014	Our results for isobaric heating dovetail with the LDA-HDA transformations reported for ST2 glassy water based on isothermal compression/decompression processes [Chiu et al., J. Chem.	Water	99-104	ST2	Homo sapiens	88-91
24844966-5	2014	RESULTS: The urinary output of VDR knockout mice decreased markedly after 48 h water deprivation [(129 +- 45 vs 1 354 +- 224) ml/24 h, P &lt; 0.05] while there was little change of urinary and plasma osmolarity.	Water	79-84	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	31-34
24144558-2	2014	Cyclic voltammetry and rotating-disk electrode measurements in nonaqueous media were used to determine the diffusion characteristics of the mediator and the kinetics of its reaction with GOx, giving a second-order rate constant of 7.6 x 10(3)-2.1 x 10(4)M(-1)s(-1) for water-acetonitrile solutions containing 5-15% water.	Water	269-274	hydroxyacid oxidase 1	Homo sapiens	187-190
24144558-2	2014	Cyclic voltammetry and rotating-disk electrode measurements in nonaqueous media were used to determine the diffusion characteristics of the mediator and the kinetics of its reaction with GOx, giving a second-order rate constant of 7.6 x 10(3)-2.1 x 10(4)M(-1)s(-1) for water-acetonitrile solutions containing 5-15% water.	Water	315-320	hydroxyacid oxidase 1	Homo sapiens	187-190
24452376-2	2014	The reabsorped water exits via basolateral AQP3 and AQP4.	Water	15-20	aquaporin 4	Homo sapiens	52-56
24563253-6	2014	Mutational analysis revealed that KIR residues involved in water-mediated contacts with the HLA-presented peptide influence peptide binding specificity.	Water	59-64	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	34-37
24469267-0	2014	Spin density distribution after electron transfer from triethylamine to an [Ir(ppy)2(bpy)]+ photosensitizer during photocatalytic water reduction.	Water	130-135	spindlin 1	Homo sapiens	0-4
24484058-7	2014	For TNT, RDX, and BP, product ions with different reduced mobility values (K0) were observed with CO3(-)(H2O)n and O2(-)(H2O)n, respectively, which is a benefit for the accurate identification.	Water	105-108	radixin	Homo sapiens	9-12
24484058-7	2014	For TNT, RDX, and BP, product ions with different reduced mobility values (K0) were observed with CO3(-)(H2O)n and O2(-)(H2O)n, respectively, which is a benefit for the accurate identification.	Water	121-124	radixin	Homo sapiens	9-12
23804246-3	2014	Here, explicit solvent molecular dynamics (MD) simulations of two bromodomains (BAZ2B and CREBBP) are used to analyze the water molecules that seem to be conserved at the bottom of the acetyl-lysine binding site in most crystal structures of bromodomains.	Water	122-127	bromodomain adjacent to zinc finger domain 2B	Homo sapiens	80-85
23361441-3	2014	Three hundred and six children aged 1 to 5 years and currently drinking tap water participated in the study.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
23443240-0	2014	A time series study of gastroenteritis and tap water quality in the Nantes area, France, 2002-2007.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
23838883-6	2014	Household tap-water arsenic, toenail arsenic and urinary inorganic arsenic and metabolites were significantly higher in Ajo (20.6+-3.5 mug/l, 0.54+-0.77 mug/g and 27.7+-21.2 mug/l, respectively) than in Tucson (3.9+-2.5 mug/l, 0.16+-0.20 mug/g and 13.0+-13.8 mug/l, respectively).	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
23860400-6	2014	Among subjects exposed to tap water As &gt;10 p.p.b., aggregate inorganic exposure was 24.5-26.1 mug/day, with approximately 30% of intake from food.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
24443781-0	2014	Perceptions of tap water and school water fountains and association with intake of plain water and sugar-sweetened beverages.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
24443781-1	2014	BACKGROUND: Little is known regarding youth perceptions of tap water and school water fountains and how these relate to water and sugar-sweetened beverage (SSB) intake.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
24443781-4	2014	Perceived tap water risk was more prevalent among non-Hispanic (NH) Blacks (26.4%) and Hispanics (28.3%) compared with NH Whites (14.7%, p &lt; .001) and more prevalent among lower-income youth.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
24443781-6	2014	Perceived tap water risk was not associated with SSB intake (odds ratio [OR] = 1.0, 95% confidence interval [CI]: 0.6, 1.5) or water intake (OR = 1.4, 95% CI: 0.9, 2.1).	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
24443781-8	2014	CONCLUSION: Negative perceptions of tap water and water fountains among youth are common and should be considered in efforts to provide water in schools.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
24642441-5	2014	The removal efficiency of zeolite LTA was evaluated by retrieving the zeolite from the water samples and adding to a fresh sample to repeat the process.	Water	87-92	lymphotoxin alpha	Homo sapiens	34-37
24642441-10	2014	The results showed that the adsorption followed pseudo-second order kinetics and suggest that zeolite LTA is a good adsorbent for the removal of nitrogen ammonia from water.	Water	167-172	lymphotoxin alpha	Homo sapiens	102-105
24434421-9	2014	These findings indicate that water-soluble isothiocyanates counteract renal dysfunction and apoptosis by up-regulating the HO-1 system and could be used as a supplementary treatment to mitigate CDDP-induced nephrotoxic effects.	Water	29-34	heme oxygenase 1	Rattus norvegicus	123-127
24586443-4	2014	We observed that S100A9KO/Tg2576 (KO/Tg) mice displayed an increased spatial reference memory in the Morris water maze task and Y-maze task as well as decreased amyloid beta peptide (Abeta) neuropathology because of reduced levels of Abeta, C-terminal fragments of amyloid precursor protein (APP-CT) and phosphorylated tau and increased expression of anti-inflammatory IL-10 and also decreased expression of inflammatory IL-6 and tumor neurosis factor (TNF)-alpha when compared with age-matched S100A9WT/Tg2576 (WT/Tg) mice.	Water	108-113	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	17-23
24456037-0	2014	Charge invariant protein-water relaxation in GB1 via ultrafast tryptophan fluorescence.	Water	25-30	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	45-48
24381181-3	2014	At 4 dpf, CaSR mRNA was increased in fish acclimated to low Ca(2+) water (25 muM vs. 250 muM in normal water).	Water	67-72	calcium-sensing receptor	Danio rerio	10-14
24382520-0	2014	Spin-orbit corrected potential energy surface features for the I ((2)P(3/2)) + H2O   HI + OH forward and reverse reactions.	Water	79-82	spindlin 1	Homo sapiens	0-4
24492660-6	2014	Our results indicated that the molecules of kB1 were trapped at the membrane-water interface.	Water	77-82	folate receptor 1 pseudogene 1	Homo sapiens	44-47
24184537-5	2014	It also proved that standard free energy of OGP micellization determined from CMC is consistent with that obtained on the basis of the free energy of the interactions between the "hydrophobic" part of the OPG through the water phase.	Water	221-226	basic transcription factor 3 pseudogene 11	Homo sapiens	205-208
24442359-11	2014	These findings suggest that Aspergillus is found in the hospital environment including the air, surface, and tap water.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
23870498-5	2014	This is consistent with the high consumption of deca-BDE in Korea and the very high octanol-water partition coefficient of deca-BDE.	Water	92-97	homeobox D13	Homo sapiens	128-131
24121662-12	2014	As the recycled water has similar effects like tap water on cloth and washing machine, it is safe to use for laundry.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	47-50
24301614-6	2014	Consistent with these data, translational knockdown of renin prevented the stimulation of Na(+) uptake following exposure to acidic or ion-poor water.	Water	144-149	renin	Danio rerio	55-60
24332350-8	2014	The fiber was successfully applied in the analysis of tap water and effluent samples from a waste water treatment plant with spike recoveries ranging from 68.5 to 105.1%.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
24332350-8	2014	The fiber was successfully applied in the analysis of tap water and effluent samples from a waste water treatment plant with spike recoveries ranging from 68.5 to 105.1%.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	54-57
24482684-10	2014	Even low levels of water-borne Mg (e.g., 15 mg/l/day) either prevented or ameliorated the upregulation of all three classes of PKC isoforms.	Water	19-24	protein kinase C zeta	Homo sapiens	127-130
24231830-0	2014	Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4, not by aquaporin-1: 17O JJVCPE MRI study in knockout mice.	Water	0-5	aquaporin 4	Mus musculus	65-76
24231830-3	2014	We investigated water flux into three representative regions of the brain, namely, the cortex, basal ganglia, and third ventricle using a newly developed water molecular MRI technique based on JJ vicinal coupling between O and adjacent protons and water molecule proton exchanges (JJVCPE imaging) in AQP-1 and AQP-4 knockout mice in vivo.	Water	154-159	aquaporin 4	Mus musculus	310-315
24231830-3	2014	We investigated water flux into three representative regions of the brain, namely, the cortex, basal ganglia, and third ventricle using a newly developed water molecular MRI technique based on JJ vicinal coupling between O and adjacent protons and water molecule proton exchanges (JJVCPE imaging) in AQP-1 and AQP-4 knockout mice in vivo.	Water	154-159	aquaporin 4	Mus musculus	310-315
24231830-4	2014	The results clearly indicate that water influx into the CSF is regulated by AQP-4, and not by AQP-1, strongly supporting the Oreskovic and Klarica hypothesis.	Water	34-39	aquaporin 4	Mus musculus	76-81
25504362-7	2014	Polymorphisms of eleven genes have been associated with stones in genome-wide association studies and replicated candidate-gene association studies: VDR, SLC34A1, SLC34A4, CLDN14, and CaSR genes coding for proteins regulating tubular phosphate and calcium reabsorption; CaSR, MGP, OPN, PLAU, and UMOD genes coding for proteins preventing calcium salt precipitation; AQP1 gene coding for a water channel in the proximal tubule.	Water	389-394	vitamin D receptor	Homo sapiens	149-152
24512661-8	2014	In the present study, biophysical chemical properties of oxidized XRCC1-NTD (wild type or mutants) were investigated at different temperatures (290, 295, 298, 301, 304, 309, 310, 311, and 312 K) in water using in silico molecular mechanic computational methods.	Water	198-203	X-ray repair cross complementing 1	Homo sapiens	66-71
24345220-2	2014	The discovery of an NMO-specific autoantibody to the aquaporin-4 (AQP4) water channel has improved knowledge of NMO pathogenesis.	Water	72-77	aquaporin 4	Homo sapiens	53-64
24345220-2	2014	The discovery of an NMO-specific autoantibody to the aquaporin-4 (AQP4) water channel has improved knowledge of NMO pathogenesis.	Water	72-77	aquaporin 4	Homo sapiens	66-70
24345221-2	2014	This changed with the discovery of NMO-immunoglobulin G (IgG), a specific autoantibody which was detected in the vast majority of NMO patients, and with the demonstration that this autoantibody targets aquaporin 4 (AQP4), a water channel found on astrocytes in the CNS.	Water	224-229	aquaporin 4	Homo sapiens	202-213
24345221-2	2014	This changed with the discovery of NMO-immunoglobulin G (IgG), a specific autoantibody which was detected in the vast majority of NMO patients, and with the demonstration that this autoantibody targets aquaporin 4 (AQP4), a water channel found on astrocytes in the CNS.	Water	224-229	aquaporin 4	Homo sapiens	215-219
24717924-2	2014	AQP3, AQP7, and AQP9, termed aqua-glyceroporins, are known to be involved in the transport of water, glycerol, and other small molecules.	Water	94-99	aquaporin 7	Rattus norvegicus	6-10
24308807-0	2014	Boiling of simulated tap water: effect on polar brominated disinfection byproducts, halogen speciation, and cytotoxicity.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
24308807-1	2014	Tap water typically contains numerous halogenated disinfection byproducts (DBPs) as a result of disinfection, especially of chlorination.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
24308807-5	2014	A novel adsorption unit for volatile total organic halogen was designed, which enabled the evaluation of halogen speciation and mass balances in the simulated tap water samples during boiling.	Water	163-168	nuclear RNA export factor 1	Homo sapiens	159-162
24308807-7	2014	The simulated tap water sample without boiling was cytotoxic in a chronic (72 h) exposure to mammalian cells; this cytotoxicity was reduced by 76.9% after boiling for 5 min.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
24308807-9	2014	Thus, boiling of tap water can be regarded as a "detoxification" process and may reduce human exposure to halogenated DBPs through tap water ingestion.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
24308807-9	2014	Thus, boiling of tap water can be regarded as a "detoxification" process and may reduce human exposure to halogenated DBPs through tap water ingestion.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	131-134
24308807-9	2014	Thus, boiling of tap water can be regarded as a "detoxification" process and may reduce human exposure to halogenated DBPs through tap water ingestion.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	17-20
24527037-2	2014	A simple and sensitive method for simultaneous analysis of five odorants in environmental water was developed by headspace solid-phase microextraction (HS-SPME) coupled to chromatography-mass spectrometry (GC-MS), including geosmin (GSM) and 2-methylisoborneol (2-MIB), as well as dimethyl trisulfide (DMTS), beta -cyclocitral, and beta -ionone.	Water	90-95	MIB E3 ubiquitin protein ligase 1	Homo sapiens	264-267
25024866-1	2014	Cu-Ni(OH)2/N-GR/Nafion/GCE has been prepared by electrodeposition and activation with NaOH.	Water	6-10	reticulon 4 receptor	Homo sapiens	11-15
23867098-3	2014	In biomass treatment, hot and high-pressure water including supercritical and subcritical water is an excellent solvent, as it is clean and safe and its action on biomass can be optimized by varying the temperature and pressure.	Water	90-95	alcohol dehydrogenase iron containing 1	Homo sapiens	22-25
24326505-9	2013	Aall adhered to a strict diet, including drinking an Italian &lt;&lt;spa water&gt;&gt; daily which he obtained in bottles from Trieste.	Water	73-78	surfactant protein A2	Homo sapiens	69-72
24634850-14	2014	Modified locust bean gum can be a promising carrier for solubility enhancement of poorly water-soluble drugs.	Water	89-94	brain expressed associated with NEDD4 1	Homo sapiens	16-20
24068044-9	2013	While AQP4 plays an important role in water exit in the CD of mammalian kidneys, it is unlikely to participate in water outflow in avian CDs.	Water	38-43	aquaporin 4	Homo sapiens	6-10
24036626-2	2013	A PLA2-sensitive amphiphilic prodrug, 1-O-octadecyl-2-(5-fluorouracil)-N-acetyl-3-zidovudine-phosphorylglycerol (OFZG), was synthesized and used to prepare nanoassemblies through the injection of a mixture of OFZG/cholesterol/Tween 80 (2:1:0.1, mol:mol:mol) into water.	Water	263-268	phospholipase A2 group IIA	Homo sapiens	2-6
23906311-5	2013	Surprisingly, sequential analysis of EAU in mice deficient in DAP12 in two different animal facilities at first revealed enhanced disease as compared with wild-type mice, but when these mice were re-derived into a second, cleaner, animal facility, the response of control mice was essentially unchanged, whereas the DAP12 null mice were markedly hyporesponsive relative to controls in the new facility.	Water	37-40	TYRO protein tyrosine kinase binding protein	Mus musculus	62-67
24649672-2	2013	Sodium sulfide dissolved in tap water was pumped into the bioreactor as sulfide for biological desulfurization.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
23912045-5	2013	The lowest energy conformer of SAR was selected for a systematic solvation study wherein different numbers of water molecules (nW, n=1-9) were placed near it.	Water	110-115	sarcosine dehydrogenase	Homo sapiens	31-34
23912045-6	2013	In the SAR-9W complex, the SAR molecule is located almost at the center of the cage of 9 water molecules.	Water	89-94	sarcosine dehydrogenase	Homo sapiens	7-10
23912045-6	2013	In the SAR-9W complex, the SAR molecule is located almost at the center of the cage of 9 water molecules.	Water	89-94	sarcosine dehydrogenase	Homo sapiens	27-30
23912045-8	2013	Proton transfer required for the formation of the zwitterionic form of SAR was found to occur when the number of water molecules in the first hydration shell was six or more.	Water	113-118	sarcosine dehydrogenase	Homo sapiens	71-74
24597042-1	2013	The objective of drinking water treatment plants (DWTP) is to supply the population with tap water that is in optimal condition and in compliance with water quality regulations.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	89-92
24312427-8	2013	Of particular interest is the result that a water-soluble PHEMA oligomer with a relatively high-molecular weight also exhibited negligible cytotoxicity, whereas the expression level of CD54 increased after exposure to PHEMA at a high concentration.	Water	44-49	intercellular adhesion molecule 1	Homo sapiens	185-189
24125471-6	2013	Detection of Au(3+) ions in complex and environmentally and biologically relevant solvents such as tap water and phosphate buffer solution (PBS) was also successfully carried out in order to demonstrate the real-life application of these sensors.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
24264037-4	2013	It was shown recently that switching of AMP/ATP binding to the insulin-independent glucose transporter Human Erythrocyte Glucose Transport Protein (GLUT1) may greatly influence the ratio of bulk and bound water during regulation of glucose uptake by red blood cells.	Water	205-210	solute carrier family 2 member 1	Homo sapiens	148-153
24148493-7	2013	When applied to spiked samples of real water, the method provided recoveries of 88.6-106.3% for tap water, 87.8-108.5% for Mi River water, 82.7-113.5% for chemical wastewater, 45.5-115.3% for urine, and 46.4-126.2% for fruit juice, with RSDs (n=5) less than 4%, 6%, 8%, 10%, and 9% respectively.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	96-99
24057107-5	2013	Also the water adsorption (at STP) capacity increased for the GQD@ZIF-8 composite as compared to the pristine ZIF-8.	Water	9-14	thyroid hormone receptor interactor 10	Homo sapiens	30-33
24032448-2	2013	Recently, there has been increasing interest in measurement and use of the less-abundant (17)O isotope in addition to (2)H and (18)O. Off-axis integrated cavity output spectroscopy (OA-ICOS) is demonstrated for accurate and precise measurements delta(18)O, delta(17)O, and (17)O-excess in liquid water.	Water	296-301	inducible T cell costimulator	Homo sapiens	185-189
24118484-3	2013	Phenotype analysis of AQP4 knockout mice indicates the involvement of AQP4 in water movement into and out of the brain, astrocyte migration, glial scar formation and neuroexcitatory phenomena.	Water	78-83	aquaporin 4	Mus musculus	22-26
24118484-3	2013	Phenotype analysis of AQP4 knockout mice indicates the involvement of AQP4 in water movement into and out of the brain, astrocyte migration, glial scar formation and neuroexcitatory phenomena.	Water	78-83	aquaporin 4	Mus musculus	70-74
23759536-0	2013	Chlorination by-products in tap water and semen quality in England and Wales.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
24499577-2	2013	The sodium-glucose cotransporter 1 (SGLT1) protein, which transports 1 glucose/2 Na+/264 H2O molecules, is described in salivary glands.	Water	89-92	solute carrier family 5 member 1	Rattus norvegicus	4-34
24499577-2	2013	The sodium-glucose cotransporter 1 (SGLT1) protein, which transports 1 glucose/2 Na+/264 H2O molecules, is described in salivary glands.	Water	89-92	solute carrier family 5 member 1	Rattus norvegicus	36-41
24499577-8	2013	This study highlights the water transporter role of SGLT1 in salivary glands, which, by increasing ductal water reabsorption, may explain the hyposalivation of diabetic and hypertensive subjects.	Water	26-31	solute carrier family 5 member 1	Rattus norvegicus	52-57
24056936-9	2013	These structures also reveal a water-mediated hydrogen bond between two conserved tyrosines, which appears to stabilize the active state of the beta2AR and related GPCRs.	Water	31-36	adrenoceptor beta 2	Homo sapiens	144-151
24022486-8	2013	CDK5, an important signal transducer in neural development and the closest known functional homolog of Pho85, does not require phosphorylation either, and we found that in its crystal structure complexed with p25 cyclin a water/hydroxide molecule remarkably plays a similar role to the phosphoryl or aspartate group.	Water	222-227	cyclin-dependent serine/threonine-protein kinase PHO85	Saccharomyces cerevisiae S288C	103-108
24063351-3	2013	This amphiphilic molecule was observed to assemble into large unilamellar vesicles (350 nm, TEM) in water and thereby entrap dimethyl phenylphosphonate (184 A(3)) in its cavity (K(app) = (1.97 +- 0.02) x 10(3) M(-1)).	Water	100-105	MFT2	Homo sapiens	92-95
23707850-4	2013	Previously, keratin extracted from feathers using alkaline hydrolysis has been made into scaffolds but with poor water stability and mechanical properties.	Water	113-118	keratin	Gallus gallus	12-19
23769186-6	2013	Cold unfiltered tap water intake at home measured by questionnaire was correlated with urinary TCAA (0.44, P=0.007), but correlation was stronger still for cold unfiltered tap water intake reported over the 3 days prior to urine sampling (0.60, P&lt;0.001).	Water	176-181	nuclear RNA export factor 1	Homo sapiens	172-175
23769186-7	2013	For unemployed women TCAA ingestion at home, derived from tap water sampling and self-reported water-use, correlated strongly with urinary TCAA (0.78, P&lt;0.001), but for employed women the correlation was weak (0.31, P=0.20).	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
23769186-8	2013	Results suggest individual tap water intake is most influential in determining TCAA exposure variability in this cohort, and that TCAA ingestion at home is a valid proxy for TCAA exposure for unemployed women but less satisfactory for employed women.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
23777639-3	2013	Study participants were 904 adult residents of Churchill County, Nevada, whose home tap water supplies contained &lt;3 to about 1200 microg of arsenic per liter.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
23777639-5	2013	Increased tap water arsenic concentration and consumption were associated with significant upward trends for urinary speciated and total and toenail total arsenical concentrations.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
24079737-4	2013	Occlusion with a water-impermeable plastic membrane partially blocked the increases in cortisol secretion and CYP11B1 and IL-1beta mRNA expression in the dry condition.	Water	17-22	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	110-117
23756162-1	2013	HLA-DO (H2-O in mice) is an intracellular non-classical MHC class II molecule (MHCII).	Water	8-12	major histocompatibility complex, class I, C	Homo sapiens	56-59
24266111-4	2013	Tap water with KMnO4 was the best cathodic electrolyte as the highest values for all the measured MFC parameters were reported with it.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
23816139-0	2013	Evaluation of CP Chromo Select Agar for the enumeration of Clostridium perfringens from water.	Water	88-93	CD46 antigen, complement regulatory protein	Mus musculus	14-16
23889610-9	2013	In the final multiple variable model, significant interactions were found between tooth brushing frequency and initial D1 status, and also between family income and home tap water fluoride level.	Water	174-179	nuclear RNA export factor 1	Homo sapiens	170-173
23889610-11	2013	More frequent tooth brushing was protective of sound surfaces, and fluoride in home tap water was also protective, but significantly more so for adolescents in low-income families.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
24043783-7	2013	First, ArpC3 was essential for robust assembly and function of tight junctions, specialized cell-cell adhesions that restrict water loss in the epidermis.	Water	126-131	actin related protein 2/3 complex subunit 3	Homo sapiens	7-12
23872186-8	2013	Eleven of the 12 tap water samples and all of the filtered tap water samples had a total bacterial load that exceeded the Thai water quality standards.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
23872186-8	2013	Eleven of the 12 tap water samples and all of the filtered tap water samples had a total bacterial load that exceeded the Thai water quality standards.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
23872186-8	2013	Eleven of the 12 tap water samples and all of the filtered tap water samples had a total bacterial load that exceeded the Thai water quality standards.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
23872186-9	2013	One of the tap water samples and one of the filtered tap water samples were found to be positive for Shigella sp., although none of the floodwater samples showed detectable levels of this pathogen as determined by PCR analysis.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
23872186-9	2013	One of the tap water samples and one of the filtered tap water samples were found to be positive for Shigella sp., although none of the floodwater samples showed detectable levels of this pathogen as determined by PCR analysis.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
23872186-11	2013	Most of the tap water samples and all filtered tap water samples were found to be contaminated with Vibrio cholerae.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
23872186-11	2013	Most of the tap water samples and all filtered tap water samples were found to be contaminated with Vibrio cholerae.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
23866131-8	2013	Dilution of urine with tap water decreased the phosphate loading on HAIX resin.	Water	27-32	nuclear RNA export factor 1	Homo sapiens	23-26
23772702-2	2013	Using a stopped-flow analysis, we showed that propofol (2,6-diisopropylphenol), a general anaesthetic drug, profoundly inhibited the osmotic water permeability of AQP4 proteoliposomes in the presence of Zn2+.	Water	141-146	aquaporin 4	Homo sapiens	163-167
23446885-0	2013	Occurrence of disinfection by-products in tap water distribution systems and their associated health risk.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
24288986-5	2013	The spatial pattern of sediment showed that TP and Fe/Al-P were higher in upstream and lower in downstream, corresponding to the spatial variation of surface water P and land-based loads from animal waste, human waste and fertilizer loss.	Water	158-163	PDZ and LIM domain 3	Homo sapiens	54-58
23764826-7	2013	The analysis of existing crystallographic data for the reactivation conformation of MetH enzyme (1K7Y (@3.0 A); 1K98 (@3.8 A) and 3IVA (@2.7 A)) indicates that the Y1139 residue and the beta-axial H2O ligand in the MetH-bound Co(II)Cbx complex are equidistant from the Co(II) ion (Y1139Co(II)=3.97 A; H2OCo(II)=3.96 A).	Water	197-200	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	84-88
23764826-7	2013	The analysis of existing crystallographic data for the reactivation conformation of MetH enzyme (1K7Y (@3.0 A); 1K98 (@3.8 A) and 3IVA (@2.7 A)) indicates that the Y1139 residue and the beta-axial H2O ligand in the MetH-bound Co(II)Cbx complex are equidistant from the Co(II) ion (Y1139Co(II)=3.97 A; H2OCo(II)=3.96 A).	Water	197-200	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	215-219
23764826-8	2013	Taking into account that the Y1139-induced Co(I)H linkages are thermodynamically more stable than the H2O-induced ones, the present calculations suggest that the Y1139 residue may serve as the beta-axial ligand in the reactivation conformation of MetH enzyme.	Water	102-105	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	247-251
23494953-6	2013	The reductions due to washing with tap water (for 10 min) and the emulsion with only egg yolk lecithin (at high concentration for 10 min) were 25.18 %, 37.83%, 21.84%, 20.87%, 13.86% and &lt; LOQ, 59.70%, 54.09%, 54.76%, 54.47%, respectively.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
23967101-8	2013	AQP1a1 appeared to be expressed predominantly on the basolateral membranes of ionocytes, suggesting its potential involvement in regulating ionocyte volume and/or water flux into the circulation.	Water	163-168	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	0-6
23967101-9	2013	Additionally, translational gene knockdown of AQP1a1 protein reduced water influx by approximately 30%, further indicating a role for AQP1a1 in facilitating transcellular water uptake.	Water	69-74	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	46-52
23967101-9	2013	Additionally, translational gene knockdown of AQP1a1 protein reduced water influx by approximately 30%, further indicating a role for AQP1a1 in facilitating transcellular water uptake.	Water	171-176	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	46-52
23967101-9	2013	Additionally, translational gene knockdown of AQP1a1 protein reduced water influx by approximately 30%, further indicating a role for AQP1a1 in facilitating transcellular water uptake.	Water	171-176	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	134-140
23997676-3	2013	The results indicate that green tea prepared with distilled water exhibits higher antioxidant activity than that made with tap water.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
23997676-4	2013	The high performance liquid chromatography showed that major constituents of green tea were found in higher concentrations in tea made with distilled water than in that made with tap water.	Water	183-188	nuclear RNA export factor 1	Homo sapiens	179-182
23747333-6	2013	Moreover, FGF-23 affected the 1,25(OH)2D3-induced change in duodenal water permeability as determined by tritiated water, but both 1,25(OH)2D3 and FGF-23 were without effects on the transepithelial fluxes of paracellular markers, (3)H-mannitol and (14)C-polyethylene glycol.	Water	69-74	fibroblast growth factor 23	Mus musculus	10-16
23747333-6	2013	Moreover, FGF-23 affected the 1,25(OH)2D3-induced change in duodenal water permeability as determined by tritiated water, but both 1,25(OH)2D3 and FGF-23 were without effects on the transepithelial fluxes of paracellular markers, (3)H-mannitol and (14)C-polyethylene glycol.	Water	115-120	fibroblast growth factor 23	Mus musculus	10-16
23806897-7	2013	Exposure of patients who have central venous catheters and other invasive devices to tap water poses a risk for infection with waterborne pathogens.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
23683957-3	2013	The aim of this work was to analyze the behavior of AnxA6 isoforms at the air/water interface alone and in the presence of membrane mimicking lipid monolayers.	Water	78-83	annexin A6	Homo sapiens	52-57
23683957-4	2013	Using Langmuir technique showed that AnxA6-2 was less adsorbed to the neat air-water interface than AnxA6-1 at acidic pH and minor differences in their PM-IRRAS spectra were observed.	Water	79-84	annexin A6	Homo sapiens	37-42
23142960-4	2013	However, since the discovery of NMO-IgG or aquaporin-4 (AQP4) antibody (AQP4-antibody), an NMO-specific autoantibody to AQP4, the dominant water channel in the central nervous system densely expressed on end-feet of astrocytes, unique clinical features, MRI and other laboratory findings in NMO have been clarified further.	Water	139-144	aquaporin 4	Homo sapiens	43-54
23142960-4	2013	However, since the discovery of NMO-IgG or aquaporin-4 (AQP4) antibody (AQP4-antibody), an NMO-specific autoantibody to AQP4, the dominant water channel in the central nervous system densely expressed on end-feet of astrocytes, unique clinical features, MRI and other laboratory findings in NMO have been clarified further.	Water	139-144	aquaporin 4	Homo sapiens	56-60
23142960-4	2013	However, since the discovery of NMO-IgG or aquaporin-4 (AQP4) antibody (AQP4-antibody), an NMO-specific autoantibody to AQP4, the dominant water channel in the central nervous system densely expressed on end-feet of astrocytes, unique clinical features, MRI and other laboratory findings in NMO have been clarified further.	Water	139-144	aquaporin 4	Homo sapiens	72-76
23142960-4	2013	However, since the discovery of NMO-IgG or aquaporin-4 (AQP4) antibody (AQP4-antibody), an NMO-specific autoantibody to AQP4, the dominant water channel in the central nervous system densely expressed on end-feet of astrocytes, unique clinical features, MRI and other laboratory findings in NMO have been clarified further.	Water	139-144	aquaporin 4	Homo sapiens	72-76
23909421-1	2013	Aquaporin-4 (AQP4), the most abundant water channel in the brain, plays a central role in water homeostasis, neuronal activity, and migration of astrocytes in the central nervous system.	Water	38-43	aquaporin 4	Homo sapiens	0-11
23909421-1	2013	Aquaporin-4 (AQP4), the most abundant water channel in the brain, plays a central role in water homeostasis, neuronal activity, and migration of astrocytes in the central nervous system.	Water	38-43	aquaporin 4	Homo sapiens	13-17
23732748-0	2013	Highly reactive (&lt;1 min) ratiometric "naked eye" detection of hypochlorite with real application in tap water.	Water	107-112	nuclear RNA export factor 1	Homo sapiens	103-106
23732748-3	2013	The chemosensor also showed excellent performance in tap water and the "dip-stick" method.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
23758528-4	2013	We find that the hydrogen bond character--more specifically, the interactions between water and pIL--is the dominant parameter responsible for lowering the LCST of PNIPAM.	Water	86-91	serpin family A member 2 (gene/pseudogene)	Homo sapiens	96-99
23874402-5	2013	The gentamicinloaded poly(dex-GMA/AAc) nanoparticles (GNPs) also further promoted blood clotting, with their favorable water uptake capacity.	Water	119-124	glycine-N-acyltransferase	Homo sapiens	34-37
23660505-8	2013	In intestinal tissues from Pept1-/- mice, no [14C]Gly-Sar transport was detectable but feces samples revealed significantly higher water content than in wild-type mice, suggesting that PEPT1 contributes to colonic water absorption.	Water	131-136	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	185-190
23660505-9	2013	In conclusion, our studies unequivocally demonstrate the presence of PEPT1 protein in healthy distal colonic epithelium in mice, rats, and humans and proved that the protein is functional and contributes to electrolyte and water handling in mice.	Water	223-228	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	69-74
23766555-1	2013	Co2+ binding to the nicotinamide adenine dinucleotide (NAD+) molecule in water solution was studied by electron paramagnetic resonance (EPR) and electron spin echo at low temperatures.	Water	73-78	spindlin 1	Homo sapiens	154-158
23980306-0	2013	Tap water iontophoresis versus glycopyrrolate iontophoresis.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
23980307-0	2013	Tap water iontophoresis versus glycopyrrolate iontophoresis.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
23351063-8	2013	A catalytic water, bound between the OE1-atoms of the two catalytic glutamates, Glu103 and Glu123, plays an important role in the enoyl-CoA isomerase and the enoyl-CoA hydratase reaction mechanism of MFE1.	Water	12-17	EBF transcription factor 1	Rattus norvegicus	37-40
23616425-1	2013	Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface.	Water	38-43	aquaporin 4	Homo sapiens	0-11
23616425-1	2013	Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface.	Water	38-43	aquaporin 4	Homo sapiens	13-17
23616425-4	2013	Protein kinase (PK)-dependent phosphorylation of Ser(111) has been reported to increase the water permeability of AQP4 expressed in an astrocytic cell line.	Water	92-97	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	0-14
23616425-4	2013	Protein kinase (PK)-dependent phosphorylation of Ser(111) has been reported to increase the water permeability of AQP4 expressed in an astrocytic cell line.	Water	92-97	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	16-18
23616425-7	2013	The water permeability of AQP4-expressing Xenopus oocytes was not altered by a range of activators and inhibitors of PKG and PKA.	Water	4-9	aquaporin 4 L homeolog	Xenopus laevis	26-30
23525971-2	2013	In 1:1 (v/v) DMSO:H2O, L exhibits high selectivity towards HF2(-) anion with a 4-fold enhancement in fluorescent intensity.	Water	18-21	complement factor H	Homo sapiens	59-62
23620481-7	2013	In 35S::AtHO1 transgenic lines, a higher level of CO and water-soluble iron, and a lower level of heme were identified, suggesting that AtHO1-regulated iron homeostasis was possibly through the catabolism of heme to produce CO and free iron.	Water	57-62	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	136-141
23503193-0	2013	Clostridium difficile contamination of public tap water distribution system during a waterborne outbreak in Finland.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
23503193-10	2013	CONCLUSIONS: Our findings demonstrate for the first time C. difficile contamination of a tap water distribution system and waterborne transmission of toxigenic C. difficile seems possible.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
24417139-2	2013	METHODS: Polysaccharides extracted from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba with water were precipitated by ethanol and named as BSEP-S and BSEP-C, respectively.	Water	104-109	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
24417139-2	2013	METHODS: Polysaccharides extracted from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba with water were precipitated by ethanol and named as BSEP-S and BSEP-C, respectively.	Water	104-109	ATP binding cassette subfamily B member 11	Homo sapiens	163-167
23677468-7	2013	Activation of the alternative pathway on activated platelets occurs when properdin is on the surface and recruits C3b or C3(H2O) to form C3b,Bb or a novel cell-bound C3 convertase [C3(H2O),Bb], which normally is present only in the fluid phase.	Water	124-127	complement C3	Homo sapiens	137-140
23674757-8	2013	CD4(+) lymph node cells from IRBP-immunized WT mice transferred EAU to naive wild-type (WT) and miR-155(-/-) mice, while miR-155(-/-) IRBP-specific T cells did not.	Water	64-67	CD4 antigen	Mus musculus	0-3
23674757-8	2013	CD4(+) lymph node cells from IRBP-immunized WT mice transferred EAU to naive wild-type (WT) and miR-155(-/-) mice, while miR-155(-/-) IRBP-specific T cells did not.	Water	64-67	retinol binding protein 3, interstitial	Mus musculus	29-33
23597372-9	2013	Those with lower levels of education were significantly less likely to drink tap water, as were their children, and significantly less likely to have had a dental appointment in the preceding past 12 months.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
23726190-7	2013	Rep-PCR banding patterns of E. coli strains were all distinguishable among the pairs of E. coli isolates recovered from produce and irrigation water on the same farm.	Water	143-148	replication protein	Escherichia coli	0-3
23338779-1	2013	The present study investigated whether a water-soluble extract from the culture medium of Ganoderma lucidum mycelia (Japanese: Reishi or Mannentake) (designated as MAK) exerted a protective effect against induction of aberrant crypt foci (ACF) by azoxymethane (AOM) and small-intestinal damage induced by the anticancer drug 5-FU.	Water	41-46	male germ cell-associated kinase	Rattus norvegicus	164-167
24900720-4	2013	As expected, the uncleaved water-soluble prodrugs 7 and 8 showed no activity toward the enzymatic targets (c-Src and c-Abl) but revealed promising antiproliferative activity in myeloid cell lines, as a consequence of the in vitro hydrolysis of the selected solubilizing moiety, followed by the release of the active compounds (1 and 2).	Water	27-32	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	117-122
23487180-6	2013	As a possible application of the acetate probes, hydrazine signaling in tap water was tested.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
23565745-2	2013	We have investigated water adsorption on the SnO2(110) surface using a combination of dynamic and static calculations to gain fundamental insight into the reaction mechanism at room temperature.	Water	21-26	strawberry notch homolog 2	Homo sapiens	45-48
23611185-1	2013	An insoluble salt of the water oxidation catalyst [Co9(H2O)6(OH)3(HPO4)2(PW9O34)3](16-) (Co9) has been used to modify amorphous carbon paste electrodes.	Water	25-30	phosphoserine phosphatase pseudogene 1	Homo sapiens	51-54
23611185-1	2013	An insoluble salt of the water oxidation catalyst [Co9(H2O)6(OH)3(HPO4)2(PW9O34)3](16-) (Co9) has been used to modify amorphous carbon paste electrodes.	Water	25-30	phosphoserine phosphatase pseudogene 1	Homo sapiens	89-92
23485789-0	2013	Aquaporin-4 expression contributes to decreases in brain water content during mouse postnatal development.	Water	57-62	aquaporin 4	Mus musculus	0-11
23485789-1	2013	The water channel protein aquaporin-4 (AQP4) is implicated to facilitate water efflux from the brain parenchyma into the blood and CSF, playing a critical role in maintaining brain water homeostasis.	Water	4-9	aquaporin 4	Mus musculus	26-37
23485789-1	2013	The water channel protein aquaporin-4 (AQP4) is implicated to facilitate water efflux from the brain parenchyma into the blood and CSF, playing a critical role in maintaining brain water homeostasis.	Water	4-9	aquaporin 4	Mus musculus	39-43
23485789-1	2013	The water channel protein aquaporin-4 (AQP4) is implicated to facilitate water efflux from the brain parenchyma into the blood and CSF, playing a critical role in maintaining brain water homeostasis.	Water	4-9	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	131-134
23485789-1	2013	The water channel protein aquaporin-4 (AQP4) is implicated to facilitate water efflux from the brain parenchyma into the blood and CSF, playing a critical role in maintaining brain water homeostasis.	Water	73-78	aquaporin 4	Mus musculus	26-37
23485789-1	2013	The water channel protein aquaporin-4 (AQP4) is implicated to facilitate water efflux from the brain parenchyma into the blood and CSF, playing a critical role in maintaining brain water homeostasis.	Water	73-78	aquaporin 4	Mus musculus	39-43
23485789-4	2013	Statistical analysis demonstrated that increased AQP4 expression partially relates to decreased brain water content in postnatal mice (r(2)=0.92 and P=0.002).	Water	102-107	aquaporin 4	Mus musculus	49-53
23485789-5	2013	Moreover, AQP4 null mice had greater brain water content than littermate controls from 2 weeks up to adult age.	Water	43-48	aquaporin 4	Mus musculus	10-14
23485789-8	2013	These results characterize the developmental feature of AQP4 expression in the postnatal brain and provide direct evidence for a role of AQP4 in postnatal brain water uptake.	Water	161-166	aquaporin 4	Mus musculus	137-141
23681730-4	2013	The latter technique was also used to examine the water accessibility for peptide-attached spin labels at different levels of membrane depth.	Water	50-55	spindlin 1	Homo sapiens	91-95
23776728-4	2013	Experimental groups received 0.05 mg/ml of C14-morphine in drinking water daily.	Water	68-73	anti-Mullerian hormone receptor type 2	Rattus norvegicus	43-46
23611991-5	2013	RESULTS: Administration of ATRA to B6 mice in which EAU was induced suppressed the response of Th17 autoreactive T cells, which was associated with decreased generation of the CD25(+) DC subset and suppressed activation of gammadelta T cells.	Water	52-55	interleukin 2 receptor, alpha chain	Mus musculus	176-180
23777080-2	2013	Neuromyelitis optica(NMO) has long been considered as a subset of multiple sclerosis but the primary target of NMO has recently been shown as a water channel aquaporin 4(AQP4) localized on the astrocytes.	Water	144-149	aquaporin 4	Homo sapiens	170-174
23239271-0	2013	Effects of protonation state of Asp181 and position of active site water molecules on the conformation of PTP1B.	Water	67-72	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	106-111
23239271-5	2013	When the active site water molecule network that is a part of the free WPDclosed crystal structure is disrupted, intermediate WPD loop conformations, similar to that in the PTPRR crystal structure, are sampled in the MD simulations.	Water	21-26	protein tyrosine phosphatase receptor type R	Homo sapiens	173-178
23239271-6	2013	In liganded PTP1B, one active site water molecule is found to be important for facilitating the orientation of Cys215 and the phosphate ion, thus may play a role in the reaction.	Water	35-40	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	12-17
23239271-7	2013	In conclusion, conformational stability of WPD loop, and possibly catalytic activity of PTP1B, is significantly affected by the protonation state of Asp181 and position of active site water molecules, showing that these aspects should be taken into consideration both in MD simulations and inhibitor design.	Water	184-189	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	88-93
23493872-6	2013	For one of the derivatives, upon dispersion of the nanoparticles in water, they spontaneously arranged into well-defined elongated nanometric tubules as detected and attested by cryo-TEM.	Water	68-73	MFT2	Homo sapiens	183-186
23521454-2	2013	The water flush consists of having patients drink tap water at end esophagography in an attempt to clear the standing barium column.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	50-53
23201922-4	2013	In addition, a very inflammatory disease of the nervous system, neuromyelitis optica, associated with blindness as well as spinal cord damage, can be distinguished by the presence of antibodies to aquaporin-4, a water channel.	Water	212-217	aquaporin 4	Homo sapiens	197-208
22965926-2	2013	The surface property changes of electrospun PCL NFMs after those plasma treatments were examined by water contact angle measurements and X-ray photoelectron spectroscopy.	Water	100-105	polycystic kidney disease 2-like 1	Mus musculus	44-47
22512727-1	2013	A newly series of water-soluble 1-alkyl-3-(4-methyl-7, 8-dihydroxy-2H-chromen-2-one) benzimidazolium chloride salts (3a-j) were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated.	Water	18-23	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	203-236
23398356-7	2013	The adsorbed Al-PAM layer was able to release trapped water overtime and became more compact, while MF1011 film became more dissipative as backbones stretched out from kaolinite surface with minimal overlapping.	Water	54-59	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	16-19
23521793-2	2013	In most NMO patients, autoantibodies to the water channel protein Aquaporin 4 (AQP4) are present at high levels and are thought to drive pathology by mediating complement-dependent destruction of astrocytes.	Water	44-49	aquaporin 4	Homo sapiens	66-77
23398240-7	2013	For a 0.6 M NaCl solution and tap water, the water flux and corresponding maximum power density were 3.7 L m(-2)h(-1) and 1.0 W/m(2) respectively at a hydraulic pressure difference of 9.8 bar.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
23398240-7	2013	For a 0.6 M NaCl solution and tap water, the water flux and corresponding maximum power density were 3.7 L m(-2)h(-1) and 1.0 W/m(2) respectively at a hydraulic pressure difference of 9.8 bar.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	30-33
23452087-10	2013	In conclusion, MDPT was found to be a water-soluble chelator showing a clear preference to soft/borderline metal-ions and a remarkable selectivity to those metal-ions vs Ca(II) ions.	Water	38-43	carbonic anhydrase 2	Homo sapiens	170-176
23364529-8	2013	These results show that CNP3 decrease water permeability of body surfaces and that both BNP and CNP3 ensure sufficient blood flow to the yolk-sac membrane for efficient salt excretion by ionocytes and sufficient water production by yolk metabolism to promote seawater adaptation during early development in medaka.	Water	212-217	natriuretic peptides B	Oryzias latipes	88-91
23364529-8	2013	These results show that CNP3 decrease water permeability of body surfaces and that both BNP and CNP3 ensure sufficient blood flow to the yolk-sac membrane for efficient salt excretion by ionocytes and sufficient water production by yolk metabolism to promote seawater adaptation during early development in medaka.	Water	212-217	C-type natriuretic peptide 3	Oryzias latipes	96-100
22588499-1	2013	Lipase enzymes catalyze the reversible hydrolysis of triacylglycerol to fatty acids and glycerol at the lipid-water interface.	Water	110-115	H16_RS31230	Ralstonia eutropha H16	0-6
23261561-4	2013	Here we use fluovideo microscopy to study the competition for adsorption at the air/water interface between the enzyme glucose oxidase (GOx) and fluid monolayers of pentadecanoic acid (PDA).	Water	84-89	hydroxyacid oxidase 1	Homo sapiens	119-134
23261561-4	2013	Here we use fluovideo microscopy to study the competition for adsorption at the air/water interface between the enzyme glucose oxidase (GOx) and fluid monolayers of pentadecanoic acid (PDA).	Water	84-89	hydroxyacid oxidase 1	Homo sapiens	136-139
23261561-5	2013	Although water soluble, GOx has a strong affinity for the air/water interface.	Water	62-67	hydroxyacid oxidase 1	Homo sapiens	24-27
23392300-0	2013	Acanthamoeba keratitis associated with tap water use during contact lens cleaning:  manufacturer guidelines need to change.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
23232971-6	2013	Drinking water arsenic concentration and intake were positively associated with MMP-9, both in crude analysis and after adjustment for gender, country/ethnicity, age, body mass index, current smoking, and diabetes.	Water	9-14	matrix metallopeptidase 9	Homo sapiens	80-85
23232971-8	2013	Using Akaike"s Information Criterion, arsenic concentration in drinking water provided a better fitting model of MMP-9 than either urinary arsenic or drinking water arsenic intake.	Water	72-77	matrix metallopeptidase 9	Homo sapiens	113-118
23428553-4	2013	Results of raw water samples from the study area showed deterioration in bacteriological quality of water moved from source to the household; from 3 to 36 cfu/100 mL for tap water and 75 to 126 cfu/100 mL for spring water, using thermotolerant coliforms (TTCs) as indicator microorganisms.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	170-173
23428553-4	2013	Results of raw water samples from the study area showed deterioration in bacteriological quality of water moved from source to the household; from 3 to 36 cfu/100 mL for tap water and 75 to 126 cfu/100 mL for spring water, using thermotolerant coliforms (TTCs) as indicator microorganisms.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	170-173
23428553-4	2013	Results of raw water samples from the study area showed deterioration in bacteriological quality of water moved from source to the household; from 3 to 36 cfu/100 mL for tap water and 75 to 126 cfu/100 mL for spring water, using thermotolerant coliforms (TTCs) as indicator microorganisms.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	170-173
23428553-4	2013	Results of raw water samples from the study area showed deterioration in bacteriological quality of water moved from source to the household; from 3 to 36 cfu/100 mL for tap water and 75 to 126 cfu/100 mL for spring water, using thermotolerant coliforms (TTCs) as indicator microorganisms.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	170-173
23532070-6	2013	In addition, a positive correlation, in both wild-type and PIP2;1-overexpressing plants, was found between Kros and the osmotic water permeability of protoplasts from the veins but not from the mesophyll.	Water	128-133	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	59-63
23356907-3	2013	The water-soluble conjugates were screened for their photodynamic efficacy against several cancer cell lines expressing different levels of GRP and integrin receptors, and their intracellular localization was evaluated via confocal fluorescence microscopy.	Water	4-9	gastrin releasing peptide	Homo sapiens	140-143
25206674-6	2013	Aquaporin 4 expression positively correlated with brain water content and the blood-brain barrier index.	Water	56-61	aquaporin 4	Homo sapiens	0-11
21914143-4	2013	High intracranial pressure despite normal ventricle size and negative MRI indicate perturbed water flux across cellular membranes, which is provided by the brain water channel aquaporin-4 (AQP4).	Water	93-98	aquaporin 4	Homo sapiens	189-193
21914143-4	2013	High intracranial pressure despite normal ventricle size and negative MRI indicate perturbed water flux across cellular membranes, which is provided by the brain water channel aquaporin-4 (AQP4).	Water	162-167	aquaporin 4	Homo sapiens	189-193
23590030-8	2013	All surfaces cleaned with tap water or tap water containing detergent revealed presence of both MRSA and XDR A. baumannii.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
23590030-11	2013	However the amounts of bacteria on the surfaces cleaned with PAL disinfectant wipes were less than those cleaned with tap water containing detergent.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
23590030-13	2013	CONCLUSION: Virusolve+ disinfectant wipes were more effective than tap water; tap water containing detergent and PAL disinfectant wipes for decontamination of bacteria inoculated on patients environmental and medical equipment surfaces at Siriraj Hospital.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
23334498-3	2013	We characterize AQP-8, identified in an ERM-1-overexpression (ERM-1[++]) suppressor screen, as a canalicular aquaporin that interacts with ERM-1 in lumen extension in a mercury-sensitive manner, implicating water-channel activity.	Water	207-212	AQuaPorin or aquaglyceroporin related	Caenorhabditis elegans	16-21
23032072-7	2013	Inhibition or deletion of ENT1 reduced the expression of type 2 excitatory amino-acid transporter (EAAT2) and the astrocyte-specific water channel, aquaporin 4 (AQP4).	Water	133-138	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	26-30
23032072-7	2013	Inhibition or deletion of ENT1 reduced the expression of type 2 excitatory amino-acid transporter (EAAT2) and the astrocyte-specific water channel, aquaporin 4 (AQP4).	Water	133-138	aquaporin 4	Mus musculus	161-165
23231966-4	2013	Water maze behavior and long-term depression (LTD) in hippocampal CA3-CA1 pathway were measured, followed by enzyme linked immunosorbent assay (ELISA), by which acetylcholine (ACh) level and acetylcholinesterase (AChE) activity were determined.	Water	0-5	carbonic anhydrase 3	Rattus norvegicus	66-73
23325252-7	2013	Thus, our results indicate that activation of TRPM2 channels is necessary for burst firing in SNr GABAergic neurons and their responsiveness to modulatory H(2)O(2).	Water	155-160	transient receptor potential cation channel subfamily M member 2	Cavia porcellus	46-51
24080549-1	2013	BACKGROUND: The natriuretic/diuretic response to atrial natriuretic peptide (ANP), an important regulator of water and Na(+) balance, is markedly attenuated in nephrotic syndrome (NS).	Water	109-114	natriuretic peptide A	Rattus norvegicus	49-75
22193336-2	2013	AQP4 has been hypothesized to modulate water and potassium fluxes associated with neuronal activity in pathophysiological states.	Water	39-44	aquaporin 4	Mus musculus	0-4
24429819-3	2013	In human and mouse intestine, the apical Na(+)/H(+) exchangers NHE2 and NHE3 affect luminal Na(+), water, and pH.	Water	99-104	solute carrier family 9 (sodium/hydrogen exchanger), member 2	Mus musculus	63-67
24429825-1	2013	BACKGROUND: We recently reported that aquaporin 5 (AQP5), a water channel never identified in the kidney before, co-localizes with pendrin at the apical membrane of type-B intercalated cells in the kidney cortex.	Water	60-65	aquaporin 5	Mus musculus	38-49
24429825-1	2013	BACKGROUND: We recently reported that aquaporin 5 (AQP5), a water channel never identified in the kidney before, co-localizes with pendrin at the apical membrane of type-B intercalated cells in the kidney cortex.	Water	60-65	aquaporin 5	Mus musculus	51-55
22939265-0	2013	Presence and sources of anthropogenic perfluoroalkyl acids in high-consumption tap-water based beverages.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
22939265-1	2013	This study investigates the presence and sources of perfluorinated alkyl acids (PFAAs) in tap water and corresponding tap-water based beverages such as coffee and cola collected in the city of Amsterdam, The Netherlands.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
22939265-1	2013	This study investigates the presence and sources of perfluorinated alkyl acids (PFAAs) in tap water and corresponding tap-water based beverages such as coffee and cola collected in the city of Amsterdam, The Netherlands.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
22939265-2	2013	Exposure pathways studies have shown that low concentrations of PFAA in tap water already may pose a high contribution to daily human exposure.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
22939265-3	2013	Tap water samples (n=4) had higher concentrations of PFAAs than the corresponding post-mixed cola (n=4).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
22939265-4	2013	The lower PFAA levels in the cola were attributed to the pre-treatment of tap water in the mixing machines and dilution with cola syrup.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
22939265-6	2013	The concentrations of PFHpA, PFOA and non branched PFOS were found to be significantly higher in manually (self) brewed coffee than in the corresponding tap water (n=4).	Water	157-162	nuclear RNA export factor 1	Homo sapiens	153-156
22939265-13	2013	Tap-water based beverages will possibly be an additional source of human exposure to PFAAs and need to be considered in exposure modeling.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
22976554-2	2013	It is distinct from multiple sclerosis and is associated with autoantibodies that target aquaporin-4 (AQP4), an astrocyte water channel.	Water	122-127	aquaporin 4	Homo sapiens	89-100
22976554-2	2013	It is distinct from multiple sclerosis and is associated with autoantibodies that target aquaporin-4 (AQP4), an astrocyte water channel.	Water	122-127	aquaporin 4	Homo sapiens	102-106
23486733-8	2013	The least concentration was seen in tap water.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
23043333-0	2013	Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in mineral water and tap water.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
23724459-10	2013	Proper CPS staining required tissue fixation in a mixture of methanol, acetone and water (2:2:1 v/v) as opposed to 4% paraformaldehyde.	Water	83-88	carbamoyl-phosphate synthase 1	Rattus norvegicus	7-10
23770751-1	2013	Spin ice is a magnetic analog of H2O ice that harbors dense static disorder.	Water	33-36	spindlin 1	Homo sapiens	0-4
22038193-2	2013	Recently, antibodies to aquaporin-4 (termed AQP4-Ab, or NMO-IgG), a water channel protein, were reported to be present in a subset of patients with SLE and neurological involvement.	Water	68-73	aquaporin 4	Homo sapiens	24-35
22038193-2	2013	Recently, antibodies to aquaporin-4 (termed AQP4-Ab, or NMO-IgG), a water channel protein, were reported to be present in a subset of patients with SLE and neurological involvement.	Water	68-73	aquaporin 4	Homo sapiens	44-48
23416590-4	2013	Moreover, NB water retains its effectiveness even after storage for 7 d. Finally, NB water produced onsite from tap water was found to be effective for removal of radioactive Cs from gravel conglomerate in Fukushima, Japan.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	112-115
23416590-4	2013	Moreover, NB water retains its effectiveness even after storage for 7 d. Finally, NB water produced onsite from tap water was found to be effective for removal of radioactive Cs from gravel conglomerate in Fukushima, Japan.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	112-115
23416590-4	2013	Moreover, NB water retains its effectiveness even after storage for 7 d. Finally, NB water produced onsite from tap water was found to be effective for removal of radioactive Cs from gravel conglomerate in Fukushima, Japan.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	112-115
23172673-4	2012	In particular, our measured scattering-length contrast of 0.204(3) fm between (18)O and (nat)O is nearly a factor of 6 greater than the tabulated value, which renders feasible neutron diffraction experiments using (18)O isotope substitution and thereby offers new possibilities for measuring the partial structure factors of oxygen-containing compounds, such as water.	Water	362-367	bromodomain containing 2	Homo sapiens	89-92
23231249-0	2012	Liquid-liquid transition in ST2 water.	Water	32-37	ST2	Homo sapiens	28-31
23231249-3	2012	13, 1011 (1992)] to calculate the free energy surface of the ST2 model of water as a function of density and bond-orientational order.	Water	74-79	ST2	Homo sapiens	61-64
22884469-3	2012	In this work we have determined the number and location of the transmembrane domains of the highly hydrophobic hepatitis C virus NS4B protein by studying the water-to-bilayer and water-to-interface transfer free energies of thirty-one different hepatitis C virus strains assuming that NS4B forms an alpha-helical wheel.	Water	158-163	polyprotein;protein F	Hepatitis C virus genotype 1	129-133
22928956-8	2012	Bivariate analyses pointed to significantly increased nickel excretion with increasing age, ingestion of dietary supplements, drinking of stagnant tap water, and consumption of nickel-rich food.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
22928956-14	2012	The use of stagnant tap water and consumption of nickel-rich food contribute to the total load.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
22871931-13	2012	Daily water intake was affected (P &lt; 0.001) by period only, with greater daily water intake in Period 2 than Period 1.	Water	6-11	period circadian regulator 2	Homo sapiens	98-106
22871931-13	2012	Daily water intake was affected (P &lt; 0.001) by period only, with greater daily water intake in Period 2 than Period 1.	Water	82-87	period circadian regulator 2	Homo sapiens	98-106
23022607-1	2012	Aquaporin-4 (AQP4) is a water channel protein mainly located in the astroglial plasma membrane, the precise function of which in the brain edema that accompanies hepatic encephalopathy (HE) is unclear.	Water	24-29	aquaporin 4	Homo sapiens	0-11
23022607-1	2012	Aquaporin-4 (AQP4) is a water channel protein mainly located in the astroglial plasma membrane, the precise function of which in the brain edema that accompanies hepatic encephalopathy (HE) is unclear.	Water	24-29	aquaporin 4	Homo sapiens	13-17
23022607-8	2012	AQP4 functional analysis (subjecting astrocytes to a hypo-osmotic medium and using flow cytometry to measure cell size) demonstrated a smaller water influx in ammonia-treated astrocytes suggesting that AQP4 aggregates are representative of an inactive status; however, more confirmatory studies are required to fully understand the functional status of AQP4 aggregates.	Water	143-148	aquaporin 4	Homo sapiens	0-4
23132680-1	2012	OBJECTIVE: Aquaporin-4 (AQP4), the main water channel protein in the brain, plays a critical role in water homeostasis and brain edema.	Water	40-45	aquaporin 4	Mus musculus	11-22
23132680-1	2012	OBJECTIVE: Aquaporin-4 (AQP4), the main water channel protein in the brain, plays a critical role in water homeostasis and brain edema.	Water	40-45	aquaporin 4	Mus musculus	24-28
23270054-0	2012	[Tap water for wound cleansing.	Water	5-10	nuclear RNA export factor 1	Homo sapiens	1-4
22995906-5	2012	We found from the simulation of the CB1-SR141716A complex that SR141716A projects toward TM5 to interact tightly with the major binding pocket, replacing the coordinated water molecules, and secures the Trp-356(6.48) rotameric switch in the inactive state to promote the formation of an extensive water-mediated H-bonding network to the highly conserved SLAXAD and NPXXY motifs in TM2/TM7.	Water	170-175	tropomyosin 3	Homo sapiens	89-92
22995906-5	2012	We found from the simulation of the CB1-SR141716A complex that SR141716A projects toward TM5 to interact tightly with the major binding pocket, replacing the coordinated water molecules, and secures the Trp-356(6.48) rotameric switch in the inactive state to promote the formation of an extensive water-mediated H-bonding network to the highly conserved SLAXAD and NPXXY motifs in TM2/TM7.	Water	297-302	tropomyosin 3	Homo sapiens	89-92
23026855-3	2012	The proposed method is very specific to Cu(ii), with tolerance against at least 100-fold amounts of other environmentally relevant metal ions except for Hg(ii) (25-fold), and was successfully applied to the detection of trace Cu(ii) in tap water, river water, and treated wastewater, and results agreed well with that determined by inductively coupled plasma-mass spectrometry (ICP-MS).	Water	240-245	nuclear RNA export factor 1	Homo sapiens	236-239
23026855-3	2012	The proposed method is very specific to Cu(ii), with tolerance against at least 100-fold amounts of other environmentally relevant metal ions except for Hg(ii) (25-fold), and was successfully applied to the detection of trace Cu(ii) in tap water, river water, and treated wastewater, and results agreed well with that determined by inductively coupled plasma-mass spectrometry (ICP-MS).	Water	253-258	nuclear RNA export factor 1	Homo sapiens	236-239
23136435-4	2012	Using molecular dynamic simulations of membrane-embedded SybII, we show that Trp residues of the JMD influence the electrostatic surface potential by controlling the position of neighboring lysine and arginine residues at the membrane-water interface.	Water	235-240	vesicle-associated membrane protein 2	Mus musculus	57-62
23199918-0	2012	Water permeability of aquaporin-4 channel depends on bilayer composition, thickness, and elasticity.	Water	0-5	aquaporin 4	Homo sapiens	22-33
23199918-1	2012	Aquaporin-4 (AQP4) is the primary water channel in the mammalian brain, particularly abundant in astrocytes, whose plasma membranes normally contain high concentrations of cholesterol.	Water	34-39	aquaporin 4	Homo sapiens	0-11
23199918-1	2012	Aquaporin-4 (AQP4) is the primary water channel in the mammalian brain, particularly abundant in astrocytes, whose plasma membranes normally contain high concentrations of cholesterol.	Water	34-39	aquaporin 4	Homo sapiens	13-17
23199918-2	2012	Here we test the hypothesis that the water permeabilities of two naturally occurring isoforms (AQP4-M1 and AQP4-M23) depend on bilayer mechanical/structural properties modulated by cholesterol and phospholipid composition.	Water	37-42	aquaporin 4	Homo sapiens	95-99
23199918-2	2012	Here we test the hypothesis that the water permeabilities of two naturally occurring isoforms (AQP4-M1 and AQP4-M23) depend on bilayer mechanical/structural properties modulated by cholesterol and phospholipid composition.	Water	37-42	aquaporin 4	Homo sapiens	107-111
23199918-8	2012	Such permeability changes could have physiological consequences, because AQP4 water permeability would be reduced by its sequestration into SM:cholesterol-enriched raft microdomains.	Water	78-83	aquaporin 4	Homo sapiens	73-77
23125098-0	2012	Glucocorticoid mediates water avoidance stress-sensitized colon-bladder cross-talk via RSK2/PSD-95/NR2B in rats.	Water	24-29	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	99-103
22849293-6	2012	PCNA elevation was detected in the submandibular gland and pancreas by 8 weeks of age in water-fed mice, and increased through 14 weeks of age, prior to overt onset of symptoms.	Water	89-94	proliferating cell nuclear antigen	Mus musculus	0-4
23458011-3	2012	In monitoring for bacterial quality of tap water it is advisable to determine glucose positive coliform bacteria, that will provide the relevance of estimation of the epidemiological safety of water use.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
23458011-4	2012	According to the method developed by the authors the calculation of the index of population risk of acute intestinal infections occurrence in dependence on the quality of tap water in Azov and Tsimlyansk towns.	Water	175-180	nuclear RNA export factor 1	Homo sapiens	171-174
23041812-12	2012	None of the environmental cultures grew M. mucogenicum except for the tap water from 2 rooms, 1 of which had a faucet aerator.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
23041812-13	2012	The 4 patient isolates and the tap water isolate from the room with the aerator were found to have greater than 98.5% similarity.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
23041812-15	2012	CONCLUSION: The source of the M. mucogenicum bacteremia outbreak was identified by genotyping analysis as the clinic tap water supply.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
22922737-6	2012	However, AQP4 expression was increased in glioma tissue with increased VEGF, vessel permeability and water content.	Water	101-106	aquaporin 4	Homo sapiens	9-13
22512996-4	2012	Using response surface methodology (RSM), the best combinations achieved were with 60% ethanol and water for 20min at 50 C. The optimized parameters for this method were compared to an extraction method that has been commonly noted in the literature, which used to be the standard method, and the results were expressed in the milligram equivalent of quercetin per gram of jam (mg E.Q/g Jam).	Water	99-104	F11 receptor	Homo sapiens	373-376
22512996-4	2012	Using response surface methodology (RSM), the best combinations achieved were with 60% ethanol and water for 20min at 50 C. The optimized parameters for this method were compared to an extraction method that has been commonly noted in the literature, which used to be the standard method, and the results were expressed in the milligram equivalent of quercetin per gram of jam (mg E.Q/g Jam).	Water	99-104	F11 receptor	Homo sapiens	387-390
22981287-0	2012	Novel Hg2+-imprinted polymers based on thymine-Hg2+-thymine interaction for highly selective preconcentration of Hg2+ in water samples.	Water	121-126	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	6-9
22998407-2	2012	The conversion of water to dioxygen in photosynthesis illustrates one example, in which a redox-inactive Ca(II) ion and four manganese ions are required for function.	Water	18-23	carbonic anhydrase 2	Homo sapiens	105-111
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	0-5	carbonic anhydrase 2	Homo sapiens	124-130
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	0-5	carbonic anhydrase 2	Homo sapiens	159-165
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	69-75	carbonic anhydrase 2	Homo sapiens	124-130
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	69-75	carbonic anhydrase 2	Homo sapiens	159-165
22985102-2	2012	ABH is broadly used in the synthesis of therapeutic drugs, whereas the ABH   H(2)O system offers a simple model to explain the conformational preferences of water linked to a constrained peptidic bond.	Water	157-162	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	71-74
22858230-3	2012	We could show that the concentration of geosmin and 2-MIB could be reduced by VUV irradiation and the combination of UV irradiation with ozone and hydrogen peroxide in pure water and water from a drinking water reservoir.	Water	173-178	MIB E3 ubiquitin protein ligase 1	Homo sapiens	54-57
22858230-3	2012	We could show that the concentration of geosmin and 2-MIB could be reduced by VUV irradiation and the combination of UV irradiation with ozone and hydrogen peroxide in pure water and water from a drinking water reservoir.	Water	183-188	MIB E3 ubiquitin protein ligase 1	Homo sapiens	54-57
22858230-3	2012	We could show that the concentration of geosmin and 2-MIB could be reduced by VUV irradiation and the combination of UV irradiation with ozone and hydrogen peroxide in pure water and water from a drinking water reservoir.	Water	183-188	MIB E3 ubiquitin protein ligase 1	Homo sapiens	54-57
22863027-0	2012	Impact of water treatment on the contribution of faucets to dissolved and particulate lead release at the tap.	Water	10-15	nuclear RNA export factor 1	Homo sapiens	106-109
22863027-1	2012	A field study was performed in a building complex to investigate the extent and sources of lead (Pb) release in tap water and brass material was found to be the main contributor in the very first draw (250 mL).	Water	116-121	nuclear RNA export factor 1	Homo sapiens	112-115
23202933-2	2012	An autoantibody (NMO IgG) against aquaporin-4 (AQP4), a water channel expressed on astrocytes is thought to be causative.	Water	56-61	aquaporin 4	Homo sapiens	34-45
21963270-7	2012	The main water soluble monomeric product of berberine oxidation under physiological-near experimental conditions, OP1, was identified as demethyleneberberine cation (2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium).	Water	9-14	bone morphogenetic protein 7	Homo sapiens	114-117
22439662-9	2012	Klotho was significantly downregulated in both NHEKs and HaCaT cells after H(2) O(2) treatment, but no SA-beta-Gal-positive HaCaT cells were seen, even after treatment with H(2) O(2) .	Water	75-81	klotho	Homo sapiens	0-6
22903615-2	2012	In this study we show that human ZAG, which is a 41-kDa protein, when administered to ob/ob mice at 50 mug/d(-1) orally in the drinking water produced a progressive loss of body weight (5 g after 8 d treatment), together with a 0.5 C increase in rectal temperature and a 40% reduction in urinary excretion of glucose.	Water	136-141	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	33-36
22206944-3	2012	The albumin was coupled to DLNE-7 globules (DLNE-8) by water soluble carbodiimide (EDC) method, purified, and quantified by modified Bradford method.	Water	55-60	albumin	Rattus norvegicus	4-11
22903161-0	2012	Roles of AQP5/AQP5-G103D in carbamylcholine-induced volume decrease and in reduction of the activation energy for water transport by rat parotid acinar cells.	Water	114-119	aquaporin 5	Rattus norvegicus	9-13
22903161-1	2012	In order to assess the contribution of the water channel aquaporin-5 (AQP5) to water transport by salivary gland acinar cells, we measured the cell volume and activation energy (E (a)) of diffusive water permeability in isolated parotid acinar cells obtained from AQP5-G103D mutant and their wild-type rats.	Water	43-48	aquaporin 5	Rattus norvegicus	70-74
22714714-1	2012	Aquaporin-4 (AQP-4), the most important water channel in the brain, is expressed by astrocyte end feet abutting microvessels.	Water	40-45	aquaporin 4	Homo sapiens	13-18
22854713-0	2012	A simple colorimetric device for rapid detection of Hg2+ in water.	Water	60-65	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	52-55
22931297-2	2012	Here, we study the dynamics of water molecules at the active site of a highly proficient enzyme, Delta(5)-3-ketosteroid isomerase (KSI), during a light-activated mimic of its catalytic cycle.	Water	31-36	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	97-129
22931297-2	2012	Here, we study the dynamics of water molecules at the active site of a highly proficient enzyme, Delta(5)-3-ketosteroid isomerase (KSI), during a light-activated mimic of its catalytic cycle.	Water	31-36	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	131-134
22931297-4	2012	The nitrile of C183 is exposed to water when bound to the KSI active site, and we used time-resolved vibrational spectroscopy as a site-specific probe to study the solvation dynamics of water molecules in the vicinity of the nitrile.	Water	34-39	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	58-61
22931297-4	2012	The nitrile of C183 is exposed to water when bound to the KSI active site, and we used time-resolved vibrational spectroscopy as a site-specific probe to study the solvation dynamics of water molecules in the vicinity of the nitrile.	Water	186-191	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	58-61
22931297-5	2012	We observed that water molecules at the active site of KSI are highly rigid, during the light-activated catalytic cycle, compared to the solvation dynamics observed in bulk water.	Water	17-22	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	55-58
22931297-5	2012	We observed that water molecules at the active site of KSI are highly rigid, during the light-activated catalytic cycle, compared to the solvation dynamics observed in bulk water.	Water	173-178	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	55-58
22882826-6	2012	The detection limit of the method was 0.08 mug L(-1) HCB for a tap-water sample.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
22931203-2	2012	Evaporation of water on a planar AgX surface leads to a strongly bound monolayer for which IR spectra display the marker peaks for modest numbers of oligomers.	Water	15-20	UDP-N-acetylglucosamine pyrophosphorylase 1	Homo sapiens	33-36
22882004-4	2012	Thus, we designed two low-molecular-weight and water-soluble prodrugs which incorporate a bisphosphonate group as a bone targeting ligand, doxorubicin as the anticancer agent, and either an acid-sensitive bond (1) or a cathepsin B cleavable bond (3) for ensuring an effective release of doxorubicin at the site of action.	Water	47-52	cathepsin B	Homo sapiens	219-230
22955663-3	2012	Film measurements were made using EDR2 film in solid water.	Water	53-58	polyhomeotic homolog 2	Homo sapiens	34-38
22570081-5	2012	In addition, to understand the structural changes that are associated with resistance, we describe the behavior of water molecules that interact simultaneously with specific residues (Glu286, Lys271 and Asp381) of c-ABL (wild type or mutant) and their relationship with drug resistance.	Water	115-120	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	214-219
22570081-8	2012	Additionally, for c-ABL mutants, the observed number of water molecules being turned over while interacting with amino acids Glu286, Lys271 and Asp381 was associated with resistance to imatinib, resulting in a less effective inhibition of the kinase activity.	Water	56-61	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	18-23
22960489-9	2012	Although males reported higher daily tap-water consumption rates than females, these differences were insignificant, so separate consumption distributions are not considered necessary.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
22960489-10	2012	A log-normal distribution provides the most adequate fit for daily tap-water intake (ml day(-1)) within both datasets.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
22771434-2	2012	Ascorbate peroxidase (APXs) plays an important role in the anti-oxidant system by utilizing AsA as specific electron donor to reduce H(2)O(2) to water.	Water	145-150	cytosolic ascorbate peroxidase 2	Solanum lycopersicum	0-20
22420587-3	2012	BMMSCs from AQP5(-/-) mice showed significantly lower plasma membrane water permeability than those from AQP5(+/+) mice.	Water	70-75	aquaporin 5	Mus musculus	12-16
22420587-10	2012	We conclude that AQP5-mediated high plasma membrane water permeability enhances the apoptosis rate of differentiating BMMSCs, thus decreasing their differentiation capacity.	Water	52-57	aquaporin 5	Mus musculus	17-21
22939141-7	2012	The electrode was tested on real samples (tap water spiked with Zn(2+), food supplement) with a good recovery by applying the standard addition method.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
22947940-5	2012	Applications to T4 lysozyme, the Trp-cage, the aquaporin channels Aqy1 and hAQP1, and the CLC-ec1 chloride antiporter are presented in which the active site geometry, the hydrophobic solvent-accessible surface, channel gating dynamics, water permeability (p(f)), and a dihedral angle are defined as functional order parameters.	Water	236-241	Charcot-Leyden crystal galectin	Homo sapiens	90-93
22658830-6	2012	Due to the paramagneticity and high saturation magnetization of Fe(3)O(4)@ALG/Fe, the used catalyst with adsorbed NOF intermediate is collected from aqueous solution by applying an external magnetic field, leading to complete removal of NOF from water samples.	Water	246-251	mitochondrial ribosomal protein L49	Homo sapiens	114-117
22658830-6	2012	Due to the paramagneticity and high saturation magnetization of Fe(3)O(4)@ALG/Fe, the used catalyst with adsorbed NOF intermediate is collected from aqueous solution by applying an external magnetic field, leading to complete removal of NOF from water samples.	Water	246-251	mitochondrial ribosomal protein L49	Homo sapiens	237-240
22677052-6	2012	Filters with deposited Ag/Al(OH)(3) mesoporous nanocomposite film have great potential for application as antimicrobial filters for tap water purification, wastewater treatment, and other bio-related applications.	Water	136-141	nuclear RNA export factor 1	Homo sapiens	132-135
22758927-3	2012	Cryo-TEM images show that particles grow via the formation of silica-Pluronic-water "flocs", which coalesce in a seemingly arbitrary manner.	Water	78-83	MFT2	Homo sapiens	5-8
22894384-3	2012	In this study, we have carried out atomistic molecular dynamics simulations of a protein-carbohydrate complex formed between the hyaluronan binding domain of the murine Cd44 protein and the octasaccharide hyaluronan in explicit water.	Water	228-233	CD44 antigen	Mus musculus	169-173
22804493-4	2012	For H(2)O@K-8, 17 positional isomeric nitroxides are predicted, not including additional numbers of regioisomers; indeed, 17 signals are observed in the (1)H NMR spectrum.	Water	4-9	keratin 8	Homo sapiens	10-13
22674433-2	2012	The positively charged hydrolysis product of cisplatin, [Pt(II)(NH(3))(2)Cl(H(2)O)](+), is in the inner core of the liposomes and negatively charged 5"-GMP embeds in the lipid bilayer of liposomes.	Water	76-82	5'-nucleotidase, cytosolic II	Homo sapiens	152-155
22805778-2	2012	The water channel proteins astrocytic aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are known to be abnormally expressed in AD brains, but the expression of AQPs surrounding SPs and cerebral amyloid angiopathy has not been described in detail.	Water	4-9	aquaporin 4	Homo sapiens	61-72
22805778-2	2012	The water channel proteins astrocytic aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are known to be abnormally expressed in AD brains, but the expression of AQPs surrounding SPs and cerebral amyloid angiopathy has not been described in detail.	Water	4-9	aquaporin 4	Homo sapiens	74-78
22385125-8	2012	During the outbreak investigation a water boiling order was enforced, as tap water was considered a potential source.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	73-76
22385125-12	2012	Among these patients, the development of diarrhoea was associated with drinking tap water with a dose-response pattern (linear increase by 2 glasses: odds ratio 1.40, 95% confidence interval 1.16-1.70).	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
22385125-14	2012	CONCLUSIONS: These findings indicated a point source contamination of tap water with a single clone of C. jejuni which likely occurred on 12-13 May.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
22834904-0	2012	Application of concentrated deep sea water inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice.	Water	37-42	sepia	Mus musculus	33-36
22834904-2	2012	Our present study was to investigate the preventive effects of natural deep-sea water on developing atopic dermatitis (AD).	Water	80-85	sepia	Mus musculus	76-79
22834904-4	2012	Deep Sea water (DSW) was filtered and concentrated by a nanofiltration process and reverse osmosis.	Water	9-14	sepia	Mus musculus	5-8
22539252-3	2012	Uptake efficiency (i.e., the amount of Orange II removed from water) increased with AAc composition in the microgels, yielding a maximum uptake efficiency of 29.5% for pNIPAm microgels with 10% AAc.	Water	62-67	glycine-N-acyltransferase	Homo sapiens	84-87
22734825-5	2012	Another isomer containing both S- and N-coordinated thiocyanato ligands, [Pt(SCN)(NCS)(H(2)dcbpy)] (1SN), was obtained as a nonluminescent yellow solid simply by exposure of 1SS H(2)O to acetone vapor at room temperature, and about 80% of 1SS H(2)O was found to be converted to 1SN.	Water	178-183	sorcin	Homo sapiens	77-80
22734825-5	2012	Another isomer containing both S- and N-coordinated thiocyanato ligands, [Pt(SCN)(NCS)(H(2)dcbpy)] (1SN), was obtained as a nonluminescent yellow solid simply by exposure of 1SS H(2)O to acetone vapor at room temperature, and about 80% of 1SS H(2)O was found to be converted to 1SN.	Water	243-248	sorcin	Homo sapiens	77-80
22817928-1	2012	A simple and straightforward quantification method integrated in a fully automated multi-pumping flow system (MPFS) using water-soluble mercaptopropionic acid (MPA)-capped CdTe quantum dots (QDs) was implemented for the fluorescence quantification of N-acetyl-L-cysteine (NAC) in pharmaceutical formulations.	Water	122-127	X-linked Kx blood group	Homo sapiens	272-275
22402780-0	2012	National screening study on 10 perfluorinated compounds in raw and treated tap water in France.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
22424887-3	2012	Aquaporin 5 (AQP5) is a membrane protein that forms water channels, and plays an important role in water transport.	Water	99-104	aquaporin 5	Rattus norvegicus	13-17
22551852-11	2012	The GM of lead concentrations in tap water was below 1 mug/L; 58% of concentrations were lower than 1 mug/L and 2.9% were higher than or equal to 10 mug/L.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
21918553-7	2012	Moreover, increased levels of IL-10 improved spatial learning, as determined by the radial arm water maze.	Water	95-100	interleukin 10	Homo sapiens	30-35
22411733-10	2012	Of the patients using bottled, distilled, or boiled tap water, 65% described the process as "mildly" or "moderately" inconvenient.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
22411733-12	2012	CONCLUSION: Despite standardized instructions for the preparation of saline irrigation solutions, many patients use untreated tap water.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
22798713-3	2012	For this purpose, SOX deficiency was produced in rats by the administration of a low molybdenum diet with concurrent addition of 200 ppm tungsten to their drinking water.	Water	164-169	quiescin sulfhydryl oxidase 1	Rattus norvegicus	18-21
22183933-1	2012	AQP4 water channels are thought to be the target of autoimmune attack in neuromyelitis optica-spectrum disorders (NMOsd).	Water	5-10	aquaporin 4	Homo sapiens	0-4
25877076-2	2012	Antibodies directed against the aquaporin-4 water channel has led to recognition of neuromyelitis optica (NMO) and NMO spectrum disorders in both children and adults and to the ability to predict a relapsing disease course in antibody-positive patients.	Water	44-49	aquaporin 4	Homo sapiens	32-43
22608187-14	2012	CONCLUSIONS: Application of the WSP to ship water systems, including potable water, recreational water facilities and decorative water features and fountains, is expected to improve water management on ships.	Water	44-49	inositol polyphosphate-5-phosphatase D	Homo sapiens	39-43
22608187-14	2012	CONCLUSIONS: Application of the WSP to ship water systems, including potable water, recreational water facilities and decorative water features and fountains, is expected to improve water management on ships.	Water	77-82	inositol polyphosphate-5-phosphatase D	Homo sapiens	39-43
22410114-0	2012	Novel cathepsin B-sensitive paclitaxel conjugate: Higher water solubility, better efficacy and lower toxicity.	Water	57-62	cathepsin B	Homo sapiens	6-17
22546863-4	2012	In the asymmetric aldol addition of p-nitrobenzaldehyde to cyclohexanone and 1-hydroxy-2-propanone in water, all the supported organocatalysts 1a-d afforded excellent isolated yields (90.2-94.7%) and stereoselectivities (96.8-97.8%ee anti, anti/syn = 91/9).	Water	102-107	synemin	Homo sapiens	245-248
22546863-5	2012	The highest catalytic property (96% yield, anti/syn = 90/10 and 99%ee anti) in water as the sole solvent was achieved under the optimized conditions.	Water	79-84	synemin	Homo sapiens	48-51
22100424-3	2012	Evidence suggests that reducing tap water temperatures in social (public) housing through "passive" means is effective in reducing risk.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
22528292-0	2012	Probing water-protein contacts in a MMP-12/CGS27023A complex by nuclear magnetic resonance spectroscopy.	Water	8-13	matrix metallopeptidase 12	Homo sapiens	36-42
22528292-1	2012	Using the case of the catalytic domain of MMP-12 in complex with the known inhibitor CGS27023A, a recently assembled 3D (15)N-edited/(14)N,(12)C-filtered ROESY experiment is used to monitor and distinguish protein amide protons in fast exchange with bulk water from amide protons close to water molecules with longer residence times, the latter possibly reflecting water molecules of structural or functional importance.	Water	255-260	matrix metallopeptidase 12	Homo sapiens	42-48
22528292-1	2012	Using the case of the catalytic domain of MMP-12 in complex with the known inhibitor CGS27023A, a recently assembled 3D (15)N-edited/(14)N,(12)C-filtered ROESY experiment is used to monitor and distinguish protein amide protons in fast exchange with bulk water from amide protons close to water molecules with longer residence times, the latter possibly reflecting water molecules of structural or functional importance.	Water	289-294	matrix metallopeptidase 12	Homo sapiens	42-48
22556341-4	2012	Tsc22d3-2 knockout mice adapted to a sodium-deprived diet and to water deprivation conditions but developed a subtle deficiency in renal sodium and water handling.	Water	65-70	TSC22 domain family, member 3	Mus musculus	0-7
22556341-4	2012	Tsc22d3-2 knockout mice adapted to a sodium-deprived diet and to water deprivation conditions but developed a subtle deficiency in renal sodium and water handling.	Water	148-153	TSC22 domain family, member 3	Mus musculus	0-7
22474011-2	2012	As a potential partial solution, we report the spontaneous polymerization of 3",5"-cyclic GMP in water, in formamide, in dimethylformamide, and (in water) in the presence of a Bronsted base such as 1,8-diazabicycloundec-7-ene.	Water	97-102	5'-nucleotidase, cytosolic II	Homo sapiens	90-93
22474011-2	2012	As a potential partial solution, we report the spontaneous polymerization of 3",5"-cyclic GMP in water, in formamide, in dimethylformamide, and (in water) in the presence of a Bronsted base such as 1,8-diazabicycloundec-7-ene.	Water	148-153	5'-nucleotidase, cytosolic II	Homo sapiens	90-93
22434272-7	2012	Tap water and river water were selected for evaluating the application to real water samples.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
22306426-6	2012	Traces of methadone and ephedrine were detected in some samples of tap water.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
22361023-2	2012	The glial water channel aquaporin-4 (AQP4) is expressed in astrocytes, and along with the inwardly-rectifying K(+) channel K(ir)4.1 is thought to underlie the reuptake of H(2)O and K(+) into glial cells during neural activity.	Water	10-15	aquaporin 4	Mus musculus	37-41
22361023-2	2012	The glial water channel aquaporin-4 (AQP4) is expressed in astrocytes, and along with the inwardly-rectifying K(+) channel K(ir)4.1 is thought to underlie the reuptake of H(2)O and K(+) into glial cells during neural activity.	Water	171-176	aquaporin 4	Mus musculus	37-41
22361023-9	2012	These results indicate a marked reduction of AQP4 following KA SE and suggest that dysregulation of water and potassium homeostasis occurs during early epileptogenesis.	Water	100-105	aquaporin 4	Mus musculus	45-49
22419561-2	2012	AQP4 water channels are concentrated in endfeet membranes of astrocytes but also localize to the fine astrocytic processes that abut central synapses.	Water	5-10	aquaporin 4	Mus musculus	0-4
22419561-3	2012	Based on its pattern of expression, we predicted that AQP4 could be involved in controlling water fluxes and changes in extracellular space (ECS) volume that are associated with activation of excitatory pathways.	Water	92-97	aquaporin 4	Mus musculus	54-58
22852425-5	2012	Using the aforementioned gas-water ratio of 10 and a hydraulic residence time (HRT) of 2 days, the mean removal efficiencies of the multi-medium CFI for NH3-N and total phosphorus were 71.7% and 63.6%, respectively-approximately twice as great as those in the non-aerated system.	Water	29-34	complement factor I	Homo sapiens	145-148
22375014-4	2012	We found that Tdp1-/- cells were not only hypersensitive to camptothecin and bleomycin but also to etoposide, methyl methanesulfonate (MMS), H(2)O(2), and ionizing radiation.	Water	141-146	tyrosyl-DNA phosphodiesterase 1	Gallus gallus	14-18
22381889-5	2012	Analysis of a mixture of 20, 40 and 60 nm nAg standards suspended in water resulted in a well resolved fractogram.	Water	69-74	NBAS subunit of NRZ tethering complex	Homo sapiens	42-45
22322152-6	2012	Meanwhile treatment of cells with 12.5 muM E Platinum resulted in conversion of water soluble LC3 (LC3-I) to lipidated and autophagosome-associated form (LC3-II) as well as increasing expression of autophagy protein Beclin 1.	Water	80-85	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	94-97
22322152-6	2012	Meanwhile treatment of cells with 12.5 muM E Platinum resulted in conversion of water soluble LC3 (LC3-I) to lipidated and autophagosome-associated form (LC3-II) as well as increasing expression of autophagy protein Beclin 1.	Water	80-85	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	99-104
22322152-6	2012	Meanwhile treatment of cells with 12.5 muM E Platinum resulted in conversion of water soluble LC3 (LC3-I) to lipidated and autophagosome-associated form (LC3-II) as well as increasing expression of autophagy protein Beclin 1.	Water	80-85	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	99-102
22205228-9	2012	In addition, apical V2R was functional upon apical desmopressin (DDAVP) treatment by demonstrating increased cAMP, water transport, and benzamil-sensitive equivalent short-circuit current (I(sc)) in cilia (-) cells but not in cilia (+) cells.	Water	115-120	arginine vasopressin receptor 2	Mus musculus	20-23
21892761-4	2012	The average bromate concentration of all tap drinking water samples was 66 mug l-1 (n = 567), almost seven times greater than the current regulatory limit in the country.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	41-44
21892761-9	2012	Bromate presence in tap drinking water can be linked to pollution in natural water bodies and the practice of using hypochlorite chemicals in addition to gaseous chlorine for water disinfection.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	20-23
21892761-9	2012	Bromate presence in tap drinking water can be linked to pollution in natural water bodies and the practice of using hypochlorite chemicals in addition to gaseous chlorine for water disinfection.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	20-23
22287575-5	2012	HW was generated by immersing a magnesium stick in tap water (Mg + 2H(2)O   Mg (OH)(2) + H(2)).	Water	55-60	USO1 vesicle transport factor	Rattus norvegicus	51-54
22227637-1	2012	The aim of this study was to evaluate the response of ABC transporters, CYP1A and class alpha (alpha) GST genes, upon water and dietary exposures to benzo(a)pyrene (BaP) in Oreochromis niloticus.	Water	118-123	cytochrome P450 1A	Oreochromis niloticus	72-77
22227637-4	2012	CYP1A mRNA expression was up-regulated in water exposed animals, with maximum fold inductions of 5, 35 and 155, respectively in liver, gill and proximal intestine.	Water	42-47	cytochrome P450 1A	Oreochromis niloticus	0-5
22060896-0	2012	Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation.	Water	123-128	heme oxygenase 1	Rattus norvegicus	23-39
22326245-1	2012	A simple method with high efficiency for generating high pure hydrogen by hydrolysis in tap water of highly activated aluminum dross is established.	Water	92-97	nuclear RNA export factor 1	Homo sapiens	88-91
22356867-10	2012	The developed methodology has been tested with spiked tap water and effluent water of a wastewater treatment plant (WWTP) obtaining recoveries in the range of 91.5-114.1% for a 20 mg P L(-1) spike concentration.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
22439773-6	2012	RESULTS: 94% of families were from the poorest communes of the city, 40% lacked sewage and 11% tap-water.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
22139469-8	2012	Maximum concentrations reached in tap water were 290 (BP3), 35 (4MBC), 110 (OD-PABA), 260 (EHMC), and 170 ng/L (OC).	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
22139469-9	2012	This study constitutes the first evidence of the presence of UV filter residues in tap water in Europe.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
22015922-2	2012	This study examined the scale up of this process for treatment of water from a ClO 4- and RDX contaminated aquifer in Cape Cod Massachusetts.	Water	66-71	radixin	Homo sapiens	90-93
22131281-1	2012	Expression of the water channel aquaporin-4 (AQP4) at the blood-brain interface is dependent upon the dystrophin associated protein complex.	Water	18-23	aquaporin 4	Mus musculus	32-43
22131281-1	2012	Expression of the water channel aquaporin-4 (AQP4) at the blood-brain interface is dependent upon the dystrophin associated protein complex.	Water	18-23	aquaporin 4	Mus musculus	45-49
22225570-1	2012	Aquaporin-4, a predominant water channel in the brain, is specifically expressed in astrocyte endfeet and plays a central role in water homeostasis, neuronal activity, and cell migration in the brain.	Water	27-32	aquaporin 4	Mus musculus	0-11
22361702-0	2012	Defensive spending on tap water substitutes: the value of reducing perceived health risks.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
22361702-1	2012	We examine factors that explain consumer spending on tap water substitutes using information from a national survey undertaken with a representative set of Canadian respondents.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
22361703-2	2012	The mean volume of tap water consumed was 1.2 L/day, with a large range (0.03 to 9.0 L/day).	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
22361703-3	2012	In-home water treatment and interactions between age and gender and age and bottled water use were significantly associated with the volume of tap water consumed in multivariable analyses.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	143-146
22361703-3	2012	In-home water treatment and interactions between age and gender and age and bottled water use were significantly associated with the volume of tap water consumed in multivariable analyses.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	143-146
22250904-3	2012	Water transport through AQP4 depends on concentration gradients across the membrane, but the rate of transport is determined by the capacity of astrocytes to up- and down-regulate AQP4 numbers, their location within the membrane, and the overall permeability of the channel.	Water	0-5	aquaporin 4	Homo sapiens	24-28
22250904-6	2012	There is abundant scientific literature on AQP4 describing its structure, function, location, and role in water homeostasis and edema in the brain.	Water	106-111	aquaporin 4	Homo sapiens	43-47
24520528-5	2012	RESULTS: Volume depletion (P &lt; 0.001) and tap water (P &lt; 0.03) both affected thirst by 13 mm per L of fluid, whereas spontaneous diuresis and infusion of Ringer"s acetate did not significantly change the thirst rating (multiple regressions).	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
24520528-8	2012	Similarly, hydration with tap water decreased thirst (by 24 mm, P &lt; 0.04) in those who were thirsty (&gt; 60 mm) while the others reported no change.	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
24520528-9	2012	CONCLUSION: The change in thirst rating during volume depletion, administration of Ringer"s acetate, and ingestion of tap water were all dependent on the thirst rating obtained when the manipulation of the body fluid volume was initiated.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
22336796-14	2012	For chronic wounds, the relative risk of developing an infection when cleansed with tap water compared with normal saline was 0.16, (95% CI 0.01 to 2.96).	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
22336796-15	2012	Tap water was more effective than saline in reducing the infection rate in adults with acute wounds (RR 0.63, 95% CI 0.40 to 0.99).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
22162438-1	2012	In light of the growing interest in the use of rare earth metal triflates as water-tolerant Lewis acid catalysts, we embarked upon the development of a solid-supported gallium triflate (PS-Ga(OTf)(2) ) derivative as a means of increasing the cleanliness and cost effectiveness of using these increasingly expensive catalytic materials in synthetic processes.	Water	77-82	POU class 2 homeobox 2	Homo sapiens	186-198
22227358-6	2012	The accuracy was in a range of 102-106% and the precision of the assay was less than 6% in chlorinated and ozonated tap water, ozonated mineral water, and sea water.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
22071246-8	2012	Addition of 2.5% sodium chloride to the drinking water for 48 h induced a two- to threefold upregulation of BGT1, tonicity-responsive enhancer binding protein, and sodium-myo-inositol cotransporter 1 (slc5a3) in the renal medulla, but not in the brain and barely in the liver.	Water	49-54	nuclear factor of activated T cells 5	Mus musculus	114-158
22051943-8	2012	In the Morris water maze test, MyD88 deficiency appeared to improve spatial learning irrespective of the transgene.	Water	14-19	myeloid differentiation primary response gene 88	Mus musculus	31-36
22238356-1	2012	OBJECTIVES: We aimed to investigate anti-aquaporin-4 (AQP-4) water channel antibodies, affecting cerebrospinal fluid (CSF) secretion and absorption, in idiopathic intracranial hypertension (IIH) patients.	Water	61-66	aquaporin 4	Homo sapiens	36-52
22238356-1	2012	OBJECTIVES: We aimed to investigate anti-aquaporin-4 (AQP-4) water channel antibodies, affecting cerebrospinal fluid (CSF) secretion and absorption, in idiopathic intracranial hypertension (IIH) patients.	Water	61-66	aquaporin 4	Homo sapiens	54-59
21643824-8	2012	Ratings for taste, clarity, purity and safety were significantly higher for bottled water than tap water (P &lt; 0.001).	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
21717208-7	2012	The survey results showed high overall scores for perception of tap water quality and safety, and a preference for tap water over bottled water.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
21717208-7	2012	The survey results showed high overall scores for perception of tap water quality and safety, and a preference for tap water over bottled water.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
21717208-7	2012	The survey results showed high overall scores for perception of tap water quality and safety, and a preference for tap water over bottled water.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
22219322-4	2012	Local delivery of purified, exogenous DC or monocytes from bone marrow substantially increased the incidence and severity of EAU induced by adoptive transfer of activated, autoreactive CD4 or CD8 T cells that was limited to the manipulated eye.	Water	125-128	CD8a molecule	Homo sapiens	192-195
22383044-5	2012	Swelling-induced ROS production in NIH3T3 fibroblasts is generated by NOX4 and by increasing total ROS, by either exogenous application of H(2)O(2) or overexpressing NOX4, we demonstrate that TonEBP activity and taurine influx are regulated negatively by ROS under hypo-osmotic, low-sodium conditions, whereas the TauT mRNA level is unaffected.	Water	139-144	nuclear factor of activated T cells 5	Mus musculus	192-198
22248451-7	2012	This hydrogen-bond network is composed of Thr75, Trp79, His88, Ser112, Pro113, Thr118-B and four water molecules, and is involved in both monomer-monomer and dimer-dimer interactions, suggesting that the double protonation of His88 by acidification breaks the hydrogen-bond network and causes the destabilization of the TTR tetramer.	Water	97-102	transthyretin	Homo sapiens	320-323
21845446-2	2012	To approach this question we combined propidium iodide/SYTO9 staining ("live/dead staining" indicating membrane integrity), fluorescence-activated cell sorting (FACS) and community fingerprinting for the analysis of a set of tap water samples.	Water	229-234	nuclear RNA export factor 1	Homo sapiens	225-228
21845446-3	2012	Live/dead staining revealed that about half of the bacteria in the tap water had intact membranes.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
22248201-4	2012	Radioactive iodine was detected at levels between 13 and 15 Bq/kg in tap water from the three facilities, but was not detected by reverse osmosis membrane at any of the facilities.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
22108345-1	2012	Chafuroside A (CFA), a poorly water-soluble flavone C-glycoside, was firstly isolated from oolong tea, and it acts as a potent anti-inflammatory agent.	Water	30-35	tubulin folding cofactor A	Rattus norvegicus	15-18
22108345-2	2012	The present study was undertaken to develop a water-soluble formulation of CFA using a self-assembled micellar (SAM) system, with the aim of improved dissolution behavior and potent anti-inflammatory effects.	Water	46-51	tubulin folding cofactor A	Rattus norvegicus	75-78
22243625-11	2012	For the residential tap water in the 7 regions, the results of the mean (range) concentration values were found to be 1.0 (0.9-1.3) Bq/L.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
22243625-14	2012	The level was much lower for tap water.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
22291652-9	2011	Dogfish AQP4 expressing-oocytes, exhibited significantly increased osmotic water permeability (P(f)) compared to controls, and this was invariant with pH.	Water	75-80	aquaporin 4 L homeolog	Xenopus laevis	8-12
22291652-11	2011	Similarly AQP4 expressing-oocytes did not exhibit enhanced urea or glycerol permeability, which is also consistent with the water-selective property of AQP4 in other species.	Water	124-129	aquaporin 4 L homeolog	Xenopus laevis	152-156
22162109-0	2012	Molecular recognition at the active site of factor Xa: cation-pi interactions, stacking on planar peptide surfaces, and replacement of structural water.	Water	146-151	coagulation factor X	Homo sapiens	44-53
22116424-3	2012	Aquaporin-4 (AQP4) is a water channel located mainly at the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) interfaces and is associated with the elimination of cerebral edema via these routes.	Water	24-29	aquaporin 4	Mus musculus	0-11
22116424-3	2012	Aquaporin-4 (AQP4) is a water channel located mainly at the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) interfaces and is associated with the elimination of cerebral edema via these routes.	Water	24-29	aquaporin 4	Mus musculus	13-17
21864501-1	2012	Cytochrome b559 (Cyt b559), beta-carotene (Car), and chlorophyll (Chl) cofactors participate in the secondary electron-transfer pathways in photosystem II (PSII), which are believed to protect PSII from photodamage under conditions in which the primary electron-donation pathway leading to water oxidation is inhibited.	Water	290-295	mitochondrially encoded cytochrome b	Homo sapiens	0-12
21830197-6	2012	The structure of AM in water is completely disordered.	Water	23-28	adrenomedullin	Homo sapiens	17-19
22006254-5	2012	There was a positive linear correlation between plasma MMP-9 and the brain water content.	Water	75-80	matrix metallopeptidase 9	Rattus norvegicus	55-60
25678938-8	2012	Aquaporin-4 (AQP4) is a likely candidate for this absorption as it is the predominant water channel in the brain.	Water	86-91	aquaporin 4	Homo sapiens	0-11
25678938-8	2012	Aquaporin-4 (AQP4) is a likely candidate for this absorption as it is the predominant water channel in the brain.	Water	86-91	aquaporin 4	Homo sapiens	13-17
22894115-8	2012	The produced CnF2n+1* reacted with H2O, forming CnF2n+1OH, then CnF2n+1OH underwent HF loss and hydrolysis to form CnF2n+1COOH.	Water	35-38	NPHS1 adhesion molecule, nephrin	Homo sapiens	13-16
22123226-12	2012	In subgroup analysis, significantly lower ORs for fever onset were observed for children who gargled with green tea (OR = 0.32), functional water (OR = 0.46), or tap water (OR = 0.70).	Water	166-171	nuclear RNA export factor 1	Homo sapiens	162-165
22363840-4	2012	NMO is associated with the NMO-IgG biomarker, which targets the aquaporin-4 water channel on astrocytes.	Water	76-81	aquaporin 4	Homo sapiens	64-75
22186307-1	2012	Gelucire 50/13 (G50/13) was assessed to develop controlled release formulation of salbutamol sulphate (SBL) a highly water soluble drug by semisolid matrix filling capsule technique.	Water	117-122	G protein subunit alpha 13	Homo sapiens	0-22
21950760-4	2012	Higher protein levels of ZmPIP1;2, ZmPIP2;1/2;2, ZmPIP2;5 and ZmPIP2;6 during the day coincided with a higher water permeability of root cortex cells during the day compared with night period.	Water	110-115	aquaporin PIP2-1	Zea mays	35-47
21950760-7	2012	These data support a role of specific PIP isoforms, in particular ZmPIP1;2 and ZmPIP2;5, in regulating root water uptake and cortex cell hydraulic conductivity in maize.	Water	108-113	aquaporin PIP2-5	Zea mays	79-87
23029330-7	2012	Number of siblings, maternal education, consumption of uncooked meat, consumption of unboiled water, and livestock ownership all correlated significantly with STH infection.	Water	94-99	saitohin	Homo sapiens	159-162
22279539-11	2012	Moreover, RKIP depletion in HEK-499, compared to control cells, bestowed resistance to supra physiological levels of H(2)O(2) and Cisplatin possibly by upregulating NF-E2-related nuclear factor 2 (NRF2) responsive genes.	Water	117-122	phosphatidylethanolamine binding protein 1	Homo sapiens	10-14
21641724-8	2012	During refeeding and body weight deficit in MTX rats, alpha-MSH IgG autoantibody levels correlated negatively with food to water intake ratios.	Water	123-128	proopiomelanocortin	Rattus norvegicus	54-63
22925856-8	2012	The trace organic chemical contaminants detected in the MBR permeate were 1 to 6 orders of magnitude lower than guideline values reported in the Australian Guidelines for Water Recycling.	Water	171-176	translocator protein	Homo sapiens	56-59
22027901-0	2011	Colorimetric detection of copper ions in tap water during the synthesis of silver/dopamine nanoparticles.	Water	45-50	nuclear RNA export factor 1	Homo sapiens	41-44
22027901-2	2011	The sensor shows excellent sensitivity and selectivity toward Cu(2+) in the range of 3.2-512 ppb and can be applied for Cu(2+) detection in tap water.	Water	144-149	nuclear RNA export factor 1	Homo sapiens	140-143
21866981-1	2011	We examine the behavior of the diffusion coefficient of the ST2 model of water over a broad region of the phase diagram via molecular dynamics simulations.	Water	73-78	ST2	Homo sapiens	60-63
21866981-6	2011	Our findings thus confirm that the low-density phase of ST2 water is a well-defined metastable liquid.	Water	60-65	ST2	Homo sapiens	56-59
22037181-8	2011	Provision of a 20 mM acetate "boost" during N starvation generates sta6 cells that become so engorged with LBs-at the expense of cytoplasm and most organelles-that they float on water even when centrifuged.	Water	178-183	uncharacterized protein	Chlamydomonas reinhardtii	67-71
22017547-0	2011	NMR studies of localized water and protein backbone dynamics in mechanically strained elastin.	Water	25-30	elastin	Homo sapiens	86-93
22017547-2	2011	Using deuterium 2D T(1)-T(2) NMR, we separate four reservoirs in the elastin-water system characterized by water with distinguishable mobilities.	Water	77-82	elastin	Homo sapiens	69-76
22017547-2	2011	Using deuterium 2D T(1)-T(2) NMR, we separate four reservoirs in the elastin-water system characterized by water with distinguishable mobilities.	Water	107-112	elastin	Homo sapiens	69-76
22048438-1	2011	We tested the association of common events in drinking water distribution systems with contamination of household tap water with human enteric viruses.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	114-117
21938401-3	2011	Inpp5k transgenic mice present defects in water metabolism characterized by a reduced plasma osmolality at baseline, a delayed urinary water excretion following a water load, and an increased acute response to vasopressin.	Water	42-47	inositol polyphosphate 5-phosphatase K	Mus musculus	0-6
21938401-3	2011	Inpp5k transgenic mice present defects in water metabolism characterized by a reduced plasma osmolality at baseline, a delayed urinary water excretion following a water load, and an increased acute response to vasopressin.	Water	135-140	inositol polyphosphate 5-phosphatase K	Mus musculus	0-6
21938401-5	2011	Analysis in a mouse collecting duct mCCD cell line revealed that Inpp5k overexpression leads to increased expression of the arginine vasopressin receptor type 2 and increased cAMP response to arginine vasopressin, providing a basis for increased aquaporin-2 expression and plasma membrane localization with increased osmotically induced water transport.	Water	337-342	inositol polyphosphate 5-phosphatase K	Mus musculus	65-71
21938401-6	2011	Altogether, our results indicate that Inpp5k 5-phosphatase is important for the control of the arginine vasopressin/aquaporin-2 signalling pathway and water transport in kidney collecting ducts.	Water	151-156	inositol polyphosphate 5-phosphatase K	Mus musculus	38-44
21924826-0	2011	Thiol-functionalization of metal-organic framework by a facile coordination-based postsynthetic strategy and enhanced removal of Hg2+ from water.	Water	139-144	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	129-132
21985704-5	2011	A large negative heat capacity change of -600 cal/(mol K) upon inhibitor binding to MTAP is consistent with altered hydrophobic interactions and release of water.	Water	156-161	methylthioadenosine phosphorylase	Homo sapiens	84-88
21981012-4	2011	The disassembly of the sacrificial layers in deionized water was completed within 47 s, when in-situ monitored at the maximum absorbance of PSP (lambda = 360 nm), employing UV/visible spectrometry.	Water	55-60	microseminoprotein beta	Homo sapiens	140-143
21855884-3	2011	Surface pressure-area measurements indicate that PMPrS-g-PDEF monolayers extensively spread at the air/water interface though PMPrS homopolymer hardly spreads.	Water	103-108	SAM pointed domain containing ETS transcription factor	Homo sapiens	57-61
21855884-5	2011	This result suggests that PMPrS main chains are detached from the water surface to aggregate together and only PDEF chains spread over the water surface.	Water	139-144	SAM pointed domain containing ETS transcription factor	Homo sapiens	111-115
21962848-5	2011	The biofilm cultures were investigated under controlled turbulent flowing conditions and nutrients were provided using a synthetic medium (tap water supplemented with nitrate, phosphate and silica) to favour the biofilm growth.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
21967647-3	2011	Due to the formation of a Meisenheimer complex between DNAN and the modifier, the modified AgNPs can detect 20 mug/L (0.2 ng) and 0.1 mg/L (1 ng) DNAN in deionized water and aged tap water, respectively.	Water	164-169	nuclear RNA export factor 1	Homo sapiens	179-182
22023861-10	2011	In the final experiment, the developed method has been successfully applied to the determination of organophosphorus pesticides in wine and tap water samples and the obtained recoveries were between 83.8% and 101.3%.	Water	144-149	nuclear RNA export factor 1	Homo sapiens	140-143
21988105-0	2011	Neutron structure of human carbonic anhydrase II: a hydrogen-bonded water network "switch" is observed between pH 7.8 and 10.0.	Water	68-73	carbonic anhydrase 2	Homo sapiens	27-48
21978216-8	2011	Rheological studies of gels of NCl-3 in water and toluene confirm their viscoelastic nature and show that the hydrogel is mechanically stronger than the toluene gel.	Water	40-45	calpain 5	Homo sapiens	31-36
21904798-8	2011	In tap water, the fluorescence of bisphenol A increases linearly versus its concentration and, its determination by direct laser photo-induced fluorescence permits to obtain a low limit of detection of 17 mug L(-1).	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
21990350-0	2011	Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet.	Water	69-74	aquaporin 4	Mus musculus	30-41
21990350-0	2011	Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet.	Water	69-74	aquaporin 4	Mus musculus	43-47
21990350-1	2011	Tissue- and cell-specific deletion of the Aqp4 gene is required to differentiate between the numerous pools of aquaporin-4 (AQP4) water channels.	Water	130-135	aquaporin 4	Mus musculus	42-46
21990350-1	2011	Tissue- and cell-specific deletion of the Aqp4 gene is required to differentiate between the numerous pools of aquaporin-4 (AQP4) water channels.	Water	130-135	aquaporin 4	Mus musculus	124-128
21990350-6	2011	Compared with litter controls, glial-conditional Aqp4 knockout mice showed a 31% reduction in brain water uptake after systemic hypoosmotic stress and a delayed postnatal resorption of brain water.	Water	100-105	aquaporin 4	Mus musculus	49-53
21990350-6	2011	Compared with litter controls, glial-conditional Aqp4 knockout mice showed a 31% reduction in brain water uptake after systemic hypoosmotic stress and a delayed postnatal resorption of brain water.	Water	191-196	aquaporin 4	Mus musculus	49-53
21858362-7	2011	The efficacy of this new type of pH sensor has been tested using tap water as a typical real sample.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
22039610-8	2011	The easy removability of CS-A from nanotubes is confirmed with X-ray photoelectron spectroscopy showing almost no detectable sulphur content after washing with water and by application of washed CS-A dispersed SWNTs in field-effect transistors.	Water	160-165	chorionic somatomammotropin hormone 1	Homo sapiens	25-29
21087145-3	2011	Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects.	Water	120-125	glutathione peroxidase 1	Homo sapiens	0-24
21087145-3	2011	Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects.	Water	120-125	glutathione peroxidase 1	Homo sapiens	26-31
21509743-0	2011	Influence of amino acid specificities on the molecular and supramolecular organization of glycine-rich elastin-like polypeptides in water.	Water	132-137	elastin	Homo sapiens	103-110
22135805-0	2011	The critical main-chain length for helix formation in water: determined in a peptide series with alternating Aib and Ala residues exclusively and detected with ECD spectroscopy.	Water	54-59	ANIB1	Homo sapiens	109-112
21227735-6	2011	Most patients cleaned their lens case with hot or cold tap water (72%).	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
21190080-2	2011	The present study aimed at assessing the temporal and spatial dynamic of trophic relevant water quality parameters in the small, deep and freshwater Peri coastal lagoon, South Brazil.	Water	90-95	perilipin 1	Homo sapiens	149-153
22991622-10	2011	There was a significant difference between the mean fluoride level of tap water (0.229 +- 0.079 ppm) and bottled water (0.111 +- 0.122 ppm) (P &lt; 0.001).	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
22991622-12	2011	CONCLUSION: Our findings revealed that the mean fluoride level of both bottled and tap water samples evaluated is con-siderably lower than accepted standards.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
21604275-1	2011	alpha-Glucosylhesperidin (Hsp-G), a functional food additive, significantly enhances the solubility and bioavailability of poorly water-soluble drugs despite little surface activity.	Water	130-135	syndecan 2	Homo sapiens	26-31
22010034-1	2011	PIP2;1 is an integral membrane protein that facilitates water transport across plasma membranes.	Water	56-61	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	0-6
22010034-8	2011	Taken together, our findings demonstrate that PIP2;1 molecules are heterogeneously distributed on the plasma membrane and that clathrin and membrane raft pathways cooperate to mediate the subcellular trafficking of PIP2;1, suggesting that the dynamic partitioning and recycling pathways might be involved in the multiple modes of regulating water permeability.	Water	341-346	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	46-52
22010034-8	2011	Taken together, our findings demonstrate that PIP2;1 molecules are heterogeneously distributed on the plasma membrane and that clathrin and membrane raft pathways cooperate to mediate the subcellular trafficking of PIP2;1, suggesting that the dynamic partitioning and recycling pathways might be involved in the multiple modes of regulating water permeability.	Water	341-346	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	215-221
21923924-5	2011	Immunohistochemistry and image analysis was performed on brainstem sections for activation of the vascular endothelial growth factor (VEGF) receptor 2 and expression of the aquaporin 4 (AQP4) water channel protein.	Water	192-197	aquaporin 4	Homo sapiens	173-184
21923924-5	2011	Immunohistochemistry and image analysis was performed on brainstem sections for activation of the vascular endothelial growth factor (VEGF) receptor 2 and expression of the aquaporin 4 (AQP4) water channel protein.	Water	192-197	aquaporin 4	Homo sapiens	186-190
21815623-0	2011	Generation of counter ion radical (Br2( -)) and its reactions in water-in-oil (CTAB or CPB)/n-butanol/cyclohexane/water) microemulsion.	Water	65-70	carboxypeptidase B1	Homo sapiens	87-90
21856282-0	2011	Water transport in human aquaporin-4: molecular dynamics (MD) simulations.	Water	0-5	aquaporin 4	Homo sapiens	25-36
21881187-2	2011	The compound is an analogue of the Ser140-Val142 segment of the water channel aquaporin-4 (AQP4).	Water	64-69	aquaporin 4	Homo sapiens	91-95
21778271-7	2011	Compared with wild-type littermates, SOCS1-Tg rats/mice developed less severe EAU.	Water	78-81	suppressor of cytokine signaling 1	Rattus norvegicus	37-42
21523511-1	2011	PURPOSE: Several poorly water-soluble drugs have previously been shown to bind to intestinal (I-FABP) and liver fatty acid binding protein (L-FABP) in vitro.	Water	24-29	fatty acid binding protein 2	Rattus norvegicus	94-100
21736312-5	2011	The fractions that individually showed higher foaming properties were mixed in binary and ternary combinations, demonstrating that MP1 when mixed with low molecular weight hydrophobic compounds strengthens the air/water interface of these solutions, a characteristic that is on the basis of sparkling wines" foamability and foam stability.	Water	214-219	pitrilysin metallopeptidase 1	Homo sapiens	131-134
21632175-1	2011	A new method has been developed for the spectrophotometric determination of p-aminophenol (PAP) in water, paracetamol formulations and human urine samples with a recovery rate between 94.9 and 101%.	Water	99-104	poly(A) polymerase alpha	Homo sapiens	76-89
21632175-1	2011	A new method has been developed for the spectrophotometric determination of p-aminophenol (PAP) in water, paracetamol formulations and human urine samples with a recovery rate between 94.9 and 101%.	Water	99-104	poly(A) polymerase alpha	Homo sapiens	91-94
21632175-6	2011	The ATPS method showed a recovery that ranged between 96.4 and 103% for the determination of PAP in natural water and wastewater samples, which was in excellent agreement with the results of the standard 4-aminoantipyrine method that was performed on the same samples.	Water	108-113	poly(A) polymerase alpha	Homo sapiens	93-96
21817792-5	2011	Additionally, a comparison of the backbone conformation is made with that of the Val141-Val142 segment of the water channel aquaporin-4 (AQP4).	Water	110-115	aquaporin 4	Homo sapiens	137-141
21700315-2	2011	Iodine-131 concentrations in tap water higher than 100 BqL(-1) were reported by several local governments in Japan following the Fukushima Daiichi Nuclear Power Plant accident.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
21700315-3	2011	Some individuals in the emergency-response community recommended the boiling of tap water to remove iodine-131.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
21700315-4	2011	However, the tap water boiling tests in this study showed no iodine-131 loss from the tap water with either short-term boiling (1-10 min) or prolonged boiling (up to 30 min) resulting in up to 3-fold volume reductions.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
21336633-12	2011	Also, fly ash and sewage sludge can be deemed stable PCB reservoirs releasing PCBs at concentrations below the regulatory cutoff to runoff water.	Water	139-144	Pyruvate carboxylase	Drosophila melanogaster	53-56
21683633-4	2011	We report the experimental observation of significant sensitivity gain for nuclear spins undergoing chemical exchange with solvent (water) at exchange rates ca 1-10 s(-1) in (1)H-(15)N correlation spectra of proteins acquired with band-selective pulses (the SOFAST-HMQC sequence).	Water	132-137	carbonic anhydrase 1	Homo sapiens	157-164
21603724-3	2011	H(2)O(2) treatment induced phosphorylation of cytosolic phospholipase A(2) (cPLA(2)) via the activation of extracellular-regulated kinase 1/2 (ERK1/2), increasing the production of lysophosphatidylethanolamine (LPE) and lysophosphatidylcholine (LPC).	Water	0-5	phospholipase A2 group IVA	Homo sapiens	46-83
21608060-10	2011	Therefore, the Mg(2+)  ion-mediated network, including the P(i)  and water molecules, increases the affinity of Hsp70 for ADP, and thus the dissociation of ADP is slow.	Water	69-74	heat shock protein family A (Hsp70) member 4	Homo sapiens	112-117
22007516-7	2011	Water extract of Schisandra chinensis (100-500 microg x mL(-1)) also exhibited inhibition on the activity of CYP450 isozymes in vitro, whereas multiple administrations (1.5 g x kg(-1), qd x 7d) had significant induction of CYP2E1 and inhibition on CYP2D2, no effect on CYP2C6, CYP3A1/2, CYP1A2 or CYP2C11.	Water	0-5	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	269-275
22007516-7	2011	Water extract of Schisandra chinensis (100-500 microg x mL(-1)) also exhibited inhibition on the activity of CYP450 isozymes in vitro, whereas multiple administrations (1.5 g x kg(-1), qd x 7d) had significant induction of CYP2E1 and inhibition on CYP2D2, no effect on CYP2C6, CYP3A1/2, CYP1A2 or CYP2C11.	Water	0-5	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	287-293
21675760-3	2011	The vesicles spontaneously formed in the PFLA/PFL-Na/H(2)O system with the rigid fluorocarbon chains were determined by atomic force microscopy images.	Water	53-58	profilin 2	Homo sapiens	41-44
21682273-6	2011	A site on a protein where a diversity of organic probes is calculated to cluster, but where water specifically does not bind, identifies a potential small-molecule binding site or protein-protein interaction hot spot.	Water	92-97	alcohol dehydrogenase iron containing 1	Homo sapiens	208-211
21396661-3	2011	However, since the discovery of an NMO-specific autoantibody to aquaporin 4 (AQP4), a dominant water channel in the central nervous system densely expressed on foot processes of astrocytes, the clinical distinction between NMO and MS has become clear, and now AQP4 antibody status is critically important for neurologists in deciding on treatment strategy.	Water	95-100	aquaporin 4	Homo sapiens	64-75
21396661-3	2011	However, since the discovery of an NMO-specific autoantibody to aquaporin 4 (AQP4), a dominant water channel in the central nervous system densely expressed on foot processes of astrocytes, the clinical distinction between NMO and MS has become clear, and now AQP4 antibody status is critically important for neurologists in deciding on treatment strategy.	Water	95-100	aquaporin 4	Homo sapiens	77-81
21623633-1	2011	Thin transparent SnO(2) films have been surface modified with cationic water-soluble porphyrins for photoelectrochemical investigations.	Water	71-76	strawberry notch homolog 2	Homo sapiens	17-20
21623633-5	2011	Both steady-state and time-resolved fluorescence studies revealed quenching of porphyrin emission upon binding to SnO(2) in water suggesting electron injection from singlet excited porphyrin to SnO(2) conduction band.	Water	124-129	strawberry notch homolog 2	Homo sapiens	114-117
21623633-5	2011	Both steady-state and time-resolved fluorescence studies revealed quenching of porphyrin emission upon binding to SnO(2) in water suggesting electron injection from singlet excited porphyrin to SnO(2) conduction band.	Water	124-129	strawberry notch homolog 2	Homo sapiens	194-197
21253892-6	2011	The peptide/MHC/TCR interface was found to hold significant number of solvent molecules, more specifically the peptide has been found to have approximately seventeen hydrogen bonds with water molecules.	Water	186-191	major histocompatibility complex, class I, C	Homo sapiens	12-15
22229131-2	2011	SETTINGS AND DESIGN: In this investigation, we evaluated 3 previously untested water-soluble PARP-1 inhibitors, namely, 3-aminobenzamide (ABA), 5-aminoisoquinolinone (AIQ), and N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide HCl (PJ-34) to determine their efficacy in blocking or attenuating CT-induced hepatotoxicity in male imprinting control region (ICR) mice.	Water	79-84	poly (ADP-ribose) polymerase family, member 1	Mus musculus	93-99
22229131-10	2011	These results demonstrate the efficacy of the 3 previously untested water-soluble PARP-1 inhibitors in attenuating CT-induced hepatocellular toxicity and further characterize the role of PARP-1 activation and oxidative stress among the cascade of events in hepatocellular necrosis induced by CT treatment.	Water	68-73	poly (ADP-ribose) polymerase family, member 1	Mus musculus	82-88
20571527-5	2011	By subtracting daily food doses of perchlorate from the oral reference dose (RfD), we derive an allowances for perchlorate in tap water for several populations.	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
22121618-2	2011	The CNTF was fabricated by vacuum filtration and was transferred CNTF to polydimethylsiloxane (PDMS) by water-assisted stamping method.	Water	104-109	ciliary neurotrophic factor	Homo sapiens	4-8
22121618-2	2011	The CNTF was fabricated by vacuum filtration and was transferred CNTF to polydimethylsiloxane (PDMS) by water-assisted stamping method.	Water	104-109	ciliary neurotrophic factor	Homo sapiens	65-69
21540348-0	2011	A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated.	Water	39-44	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	80-86
21664393-3	2011	Rats were fed 4% fructose in drinking water for 8 weeks, and ADM was administered subcutaneously in pure water through an Alzet Mini-osmotic Pump at 300 ng/kg/h for the last 4 weeks.	Water	105-110	adrenomedullin	Rattus norvegicus	61-64
21689703-8	2011	High atrial stretch induced by elevating the height of outflow catheter from 5 cm H2O to 7.5 cm H2O increased atrial contractility and ANP secretion.	Water	82-85	natriuretic peptide A	Rattus norvegicus	135-138
21689703-8	2011	High atrial stretch induced by elevating the height of outflow catheter from 5 cm H2O to 7.5 cm H2O increased atrial contractility and ANP secretion.	Water	96-99	natriuretic peptide A	Rattus norvegicus	135-138
21612240-1	2011	The binding of Sr(II), Ca(II), Mg(II), Ba(II), Mn(II), Zn(II), and Cd(II) to silica/water interfaces functionalized with A(15)T(6) oligonucleotides was quantified at pH 7 and 10 mM NaCl using the Eisenthal chi((3)) technique.	Water	84-89	carbonic anhydrase 2	Homo sapiens	23-29
26596451-5	2011	The developed nonbonded force field parameters were found to be transferrable to poly(propylene oxide) (PPO), as confirmed by capturing, at least qualitatively, the miscibility of PPO in water as a function of the molecular weight.	Water	187-192	polyphenol oxidase, chloroplastic	Malus domestica	104-107
26596451-5	2011	The developed nonbonded force field parameters were found to be transferrable to poly(propylene oxide) (PPO), as confirmed by capturing, at least qualitatively, the miscibility of PPO in water as a function of the molecular weight.	Water	187-192	polyphenol oxidase, chloroplastic	Malus domestica	180-183
21640375-13	2011	Tap water iodine concentrations were low or undetectable and were not positively associated with urinary iodine concentrations.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
21552296-1	2011	Aquaporin-4 (AQP4) is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle.	Water	24-29	aquaporin 4	Mus musculus	0-11
21552296-1	2011	Aquaporin-4 (AQP4) is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle.	Water	24-29	aquaporin 4	Mus musculus	13-17
21552296-3	2011	Phenotype analysis of AQP4-null mice indicates the involvement of AQP4 in brain and spinal cord water balance, astrocyte migration, neural signal transduction and neuroinflammation.	Water	96-101	aquaporin 4	Mus musculus	22-26
21552296-3	2011	Phenotype analysis of AQP4-null mice indicates the involvement of AQP4 in brain and spinal cord water balance, astrocyte migration, neural signal transduction and neuroinflammation.	Water	96-101	aquaporin 4	Mus musculus	66-70
21552296-9	2011	Our findings suggest the potential utility of AQP4-based therapeutics, including small-molecule modulators of AQP4 water transport function for therapy of brain swelling, injury and epilepsy, as well as small-molecule or monoclonal antibody blockers of NMO-IgG binding to AQP4 for therapy of NMO.	Water	115-120	aquaporin 4	Mus musculus	46-50
21552296-9	2011	Our findings suggest the potential utility of AQP4-based therapeutics, including small-molecule modulators of AQP4 water transport function for therapy of brain swelling, injury and epilepsy, as well as small-molecule or monoclonal antibody blockers of NMO-IgG binding to AQP4 for therapy of NMO.	Water	115-120	aquaporin 4	Mus musculus	110-114
21552296-9	2011	Our findings suggest the potential utility of AQP4-based therapeutics, including small-molecule modulators of AQP4 water transport function for therapy of brain swelling, injury and epilepsy, as well as small-molecule or monoclonal antibody blockers of NMO-IgG binding to AQP4 for therapy of NMO.	Water	115-120	aquaporin 4	Mus musculus	110-114
20724552-2	2011	The mechanisms by which CFTR mutations cause lung disease in CF are not fully defined but may include altered ion and water transport across the airway epithelium and aberrant inflammatory and immune responses to pathogens within the airways.	Water	118-123	cystic fibrosis transmembrane conductance regulator	Mus musculus	24-28
21293384-0	2011	Severe combined immunodeficiency in Frisian Water Dogs caused by a RAG1 mutation.	Water	44-49	recombination activating 1	Canis lupus familiaris	67-71
21446052-1	2011	Aquaporin-4 (AQP4) is the main water channel in the brain and primarily localized to astrocytes where the channels are thought to contribute to water and K(+) homeostasis.	Water	31-36	aquaporin 4	Mus musculus	0-11
21446052-1	2011	Aquaporin-4 (AQP4) is the main water channel in the brain and primarily localized to astrocytes where the channels are thought to contribute to water and K(+) homeostasis.	Water	31-36	aquaporin 4	Mus musculus	13-17
21446052-1	2011	Aquaporin-4 (AQP4) is the main water channel in the brain and primarily localized to astrocytes where the channels are thought to contribute to water and K(+) homeostasis.	Water	144-149	aquaporin 4	Mus musculus	0-11
21446052-1	2011	Aquaporin-4 (AQP4) is the main water channel in the brain and primarily localized to astrocytes where the channels are thought to contribute to water and K(+) homeostasis.	Water	144-149	aquaporin 4	Mus musculus	13-17
21424125-2	2011	Aquaporin-4 (AQP4) is a key molecule involved in maintaining water and ion homeostasis in the central nervous system and has been recently reported to play a role in cell migration in addition to its well-known function in brain edema.	Water	61-66	aquaporin 4	Homo sapiens	0-11
21424125-2	2011	Aquaporin-4 (AQP4) is a key molecule involved in maintaining water and ion homeostasis in the central nervous system and has been recently reported to play a role in cell migration in addition to its well-known function in brain edema.	Water	61-66	aquaporin 4	Homo sapiens	13-17
21122919-4	2011	Male mice were chronically administrated with CORT drinking water (20mg/L) during adolescence.	Water	60-65	cortistatin	Mus musculus	46-50
19632743-4	2011	Water maze experience significantly increased Fos expression in the suprapyramidal blade and Fos was highest in the septal pole of the dentate gyrus whether the animal learned a platform location, swam in the absence of a platform or remained in their cage.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-49
19632743-4	2011	Water maze experience significantly increased Fos expression in the suprapyramidal blade and Fos was highest in the septal pole of the dentate gyrus whether the animal learned a platform location, swam in the absence of a platform or remained in their cage.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	93-96
21634076-0	2004	(67/68)Ga-Tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid-1,2-diaminoethane-gamma-folate Folic acid (folate) is a water-soluble B vitamin (1) that is essential for methylation and DNA synthesis.	Water	119-124	mediator complex subunit 25	Homo sapiens	58-64
21334835-3	2011	Temporal variation in tap water delta(18)O was correlated with water-supply type, and was related to geographic patterns of precipitation delta(18)O seasonality and water residence time.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
21334835-3	2011	Temporal variation in tap water delta(18)O was correlated with water-supply type, and was related to geographic patterns of precipitation delta(18)O seasonality and water residence time.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	22-25
21334835-6	2011	Incorporation of tap water delta(18)O seasonality in the analysis reduces the precision of geographic assignments, but other sources of uncertainty (e.g., spatial interpolation uncertainty) have an equal or larger effect.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
21330657-6	2011	EAU was induced in wild-type (WT) mice and in mice lacking IL-6 (IL-6KO), IL-17 (IL-17KO), and IFN-gamma (GKO) on a C57BL/6 background.	Water	0-3	interleukin 17A	Mus musculus	74-79
21330657-6	2011	EAU was induced in wild-type (WT) mice and in mice lacking IL-6 (IL-6KO), IL-17 (IL-17KO), and IFN-gamma (GKO) on a C57BL/6 background.	Water	0-3	interleukin 17A	Mus musculus	81-88
21376440-3	2011	The daily intakes through tap water consumption ranged from &lt;0.01 to 0.73 ng kg(-1) d(-1) for perfluorooctanoate (PFOA) and &lt;0.01 to 0.08 ng kg(-1) d(-1) for perfluorooctanesulfonate (PFOS).	Water	30-35	nuclear RNA export factor 1	Homo sapiens	26-29
21376440-4	2011	Tap water intake-derived exposure accounted for 8.6%-101% (for PFOA) and while &lt;10% (for PFOS) of total daily exposure, which was estimated from Korean serum concentrations using a pharmacokinetic model.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
21376440-5	2011	Our findings indicate that tap water intake could be an important contributor to PFOA exposure in Korean populations; accordingly, additional efforts are necessary to improve the removal efficiency of perfluorinated compounds (PFCs) in the water purification process.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
21376440-5	2011	Our findings indicate that tap water intake could be an important contributor to PFOA exposure in Korean populations; accordingly, additional efforts are necessary to improve the removal efficiency of perfluorinated compounds (PFCs) in the water purification process.	Water	240-245	nuclear RNA export factor 1	Homo sapiens	27-30
20856251-3	2011	RESULTS: Animals treated with ZAG showed a progressive decrease in body weight, without a decrease in food and water intake, but with a 0.4  C rise in body temperature.	Water	111-116	alpha-2-glycoprotein 1, zinc-binding	Rattus norvegicus	30-33
20084436-7	2011	Good detection limits have been obtained, i.e.: 0.35 microg.L(-1) of chlorophenol in tap water, which are always lower than the reported Predictive Non Efficient Concentration (PNEC).	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
21500270-0	2011	Spin-locking versus chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons.	Water	114-119	spindlin 1	Homo sapiens	0-4
21359299-0	2011	Asymmetric syn-selective direct aldol reaction of protected hydroxyacetone catalyzed by primary amino acid derived bifunctional organocatalyst in the presence of water.	Water	162-167	synemin	Homo sapiens	11-14
21477270-8	2011	Point mutations in the DrAqp3b amino acid sequence rendered two constructs, DrAqp3b-T85A showing higher water and ethylene glycol permeability at neutral and alkaline pH, and DrAqp3b-H53A/G54H/T85A, no longer inhibited at acidic pH but less permeable than the wild type.	Water	104-109	aquaporin 3b	Danio rerio	23-30
21477270-8	2011	Point mutations in the DrAqp3b amino acid sequence rendered two constructs, DrAqp3b-T85A showing higher water and ethylene glycol permeability at neutral and alkaline pH, and DrAqp3b-H53A/G54H/T85A, no longer inhibited at acidic pH but less permeable than the wild type.	Water	104-109	aquaporin 3b	Danio rerio	76-83
21477270-8	2011	Point mutations in the DrAqp3b amino acid sequence rendered two constructs, DrAqp3b-T85A showing higher water and ethylene glycol permeability at neutral and alkaline pH, and DrAqp3b-H53A/G54H/T85A, no longer inhibited at acidic pH but less permeable than the wild type.	Water	104-109	aquaporin 3b	Danio rerio	76-83
21435449-7	2011	In contrast, genetic knockdown of CDK5 or treatment with the CDK5 inhibitor roscovitine improved behavioral performance in the water maze test and reduced neurodegeneration, abnormal tau phosphorylation, and astrogliosis in gp120 transgenic mice.	Water	127-132	cyclin-dependent kinase 5	Mus musculus	34-38
21435449-7	2011	In contrast, genetic knockdown of CDK5 or treatment with the CDK5 inhibitor roscovitine improved behavioral performance in the water maze test and reduced neurodegeneration, abnormal tau phosphorylation, and astrogliosis in gp120 transgenic mice.	Water	127-132	cyclin-dependent kinase 5	Mus musculus	61-65
21331487-0	2011	Development of a new three-phase membrane-assisted liquid-phase microextraction method: determination of nitrite in tap water samples as model analytical application.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
21331487-4	2011	The device has been tested for the determination of nitrite in tap water samples, which is extensively carried out in routine analysis, as model analytical application.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
21331487-7	2011	The method has been applied to four tap water samples of different origins, and accurate and precise results were achieved.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
21367603-0	2011	Fluorescent water soluble polymers for isozyme-selective interactions with matrix metalloproteinase-9.	Water	12-17	matrix metallopeptidase 9	Homo sapiens	75-101
21367603-3	2011	Herein, we report the synthesis and molecular interactions of two water soluble, fluorescent polymers which demonstrate selective interactions with MMP-9 compared to MMP-7 and -10.	Water	66-71	matrix metallopeptidase 9	Homo sapiens	148-153
21247614-3	2011	Laboratory experiments were conducted with dechlorinated tap water over a pH range of 3, 7 and 9.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
21247614-11	2011	However, uptake rates in different aqueous matrixes declined in the order of deionized water&gt;Plastic Lake water&gt;dechlorinated tap water, so other parameters must affect uptake into POCIS, although this influence will be minor.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	132-135
21247614-11	2011	However, uptake rates in different aqueous matrixes declined in the order of deionized water&gt;Plastic Lake water&gt;dechlorinated tap water, so other parameters must affect uptake into POCIS, although this influence will be minor.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	132-135
21247614-11	2011	However, uptake rates in different aqueous matrixes declined in the order of deionized water&gt;Plastic Lake water&gt;dechlorinated tap water, so other parameters must affect uptake into POCIS, although this influence will be minor.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	132-135
21256669-0	2011	Irrigation of continent catheterizable ileal pouches: tap water can replace sterile solutions because it is safe, easy, and economical.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
21256669-2	2011	OBJECTIVE: Our aim was to compare the UTI rate, patient friendliness, and costs of standard sterile irrigation versus irrigation with tap water.	Water	138-143	nuclear RNA export factor 1	Homo sapiens	134-137
21256669-5	2011	INTERVENTION: Patients underwent daily pouch irrigations with NaCl 0.9% solution or tap water.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
21256669-13	2011	CONCLUSIONS: Pouch irrigation with sterile NaCl 0.9% solution and tap water had comparable rates of positive UC.	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
21256669-14	2011	Irrigation with tap water significantly lowered the incidence of nitrite-positive study days and was substantially less costly and more patient friendly than NaCl irrigation.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
21256669-15	2011	We therefore recommend the use of tap water (or bottled water) instead of sterile NaCl 0.9% solution for daily irrigation of continent catheterizable ileal pouches.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
21277814-1	2011	Spin-lattice relaxation times (T1s) of small water-soluble spin-labels in the aqueous phase as well as lipid-type spin-labels in membranes increase when the microwave frequency increases from 2 to 35 GHz (Hyde, et al., J. Phys.	Water	45-50	spindlin 1	Homo sapiens	0-4
21277814-1	2011	Spin-lattice relaxation times (T1s) of small water-soluble spin-labels in the aqueous phase as well as lipid-type spin-labels in membranes increase when the microwave frequency increases from 2 to 35 GHz (Hyde, et al., J. Phys.	Water	45-50	spindlin 1	Homo sapiens	59-63
21277814-4	2011	The T1s measured at W-band (94 GHz) for the water-soluble spin-labels CTPO and TEMPONE (Froncisz, et al., J. Magn.	Water	44-49	spindlin 1	Homo sapiens	58-62
21424546-0	2011	RrS1-like sequences of water frogs from Central Europe and around the Aegean Sea: chromosomal organization, evolution, possible function.	Water	23-28	ribosome biogenesis regulator 1 homolog	Homo sapiens	0-4
21424546-1	2011	RrS1-like sequences of water frogs (genus Pelophylax) display varied genomic organization, whereas the centromeric hybridization pattern reveals species-specific differences.	Water	23-28	ribosome biogenesis regulator 1 homolog	Homo sapiens	0-4
21551998-3	2011	Patients in the experimental group drank carbonated water and those in the control group drank tap water for two weeks.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
21374812-6	2011	The utility of the column was demonstrated for the determination of UV-absorbing anions in saliva and tap water.	Water	106-111	nuclear RNA export factor 1	Homo sapiens	102-105
21256195-10	2011	The strikingly high expression of AQP4 in the CA1 SLM and DG ML identifies these regions as potential sites of astrocytic K+ and H2O regulation.	Water	129-132	aquaporin 4	Mus musculus	34-38
21389983-9	2011	A key feature of this conformational change is a reorganization of water-mediated hydrogen-bond networks between the retinal-binding pocket and three of the most conserved GPCR sequence motifs.	Water	67-72	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	172-176
21483824-5	2011	We solved the crystal structure of its complex with the human VDR-LBD and found that this natural metabolite displays specific adaptation of the ligand-binding pocket, as the 3-epimer maintains the number of hydrogen bonds by an alternative water-mediated interaction to compensate the abolished interaction with Ser278.	Water	241-246	vitamin D receptor	Homo sapiens	62-65
21332115-5	2011	Structural characterization of the library compounds in complex with human CA II revealed a novel binding mode whereby a methyl ester interacts via a water molecule with the active site zinc.	Water	150-155	carbonic anhydrase 2	Homo sapiens	75-80
21286625-0	2011	A highly specific rhodamine-based colorimetric probe for hypochlorites: a new sensing strategy and real application in tap water.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
22235396-1	2011	New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10(-9)M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H(2)O(2)and glutamate.	Water	230-235	nerve growth factor	Mus musculus	4-23
22235396-1	2011	New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10(-9)M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H(2)O(2)and glutamate.	Water	230-235	nerve growth factor	Mus musculus	25-28
21190899-1	2011	NMO-IgG is a specific biomarker of neuromyelitis optica (NMO) that targets the aquaporin-4 (AQP4) water channel protein.	Water	98-103	aquaporin 4	Homo sapiens	79-90
21190899-1	2011	NMO-IgG is a specific biomarker of neuromyelitis optica (NMO) that targets the aquaporin-4 (AQP4) water channel protein.	Water	98-103	aquaporin 4	Homo sapiens	92-96
21586376-15	2011	With multivariate analysis, after adjusting for all significant variables, abnormal water swallowing test (P = 0.0002, OR 13) emerged as the sole independent parameter associated with laryngeal penetrations.	Water	84-89	olfactory receptor family 10 subfamily T member 2	Homo sapiens	119-124
21072593-5	2011	Additionally, it was documented that in water-restricted old rats, a situation that normally induces an increase in the number of NKCC2 in young rats is absent in old ones.	Water	40-45	solute carrier family 12 member 1	Rattus norvegicus	130-135
20878681-1	2011	The present study involves the utilization of replica exchange molecular dynamics (REMD) methodology to explore the conformational space of Neuromedin C (NMC) using implicit (REMD(implicit) ) and explicit (REMD(explicit) ) water models.	Water	223-228	gastrin releasing peptide	Homo sapiens	140-152
20878681-1	2011	The present study involves the utilization of replica exchange molecular dynamics (REMD) methodology to explore the conformational space of Neuromedin C (NMC) using implicit (REMD(implicit) ) and explicit (REMD(explicit) ) water models.	Water	223-228	gastrin releasing peptide	Homo sapiens	154-157
21283224-5	2011	We have demonstrated that Raman spectroscopy is substantially more sensitive to water perturbation compared to conventional acoustic (sonar) technique and can be used for ship wake detection and monitoring.	Water	80-85	inositol polyphosphate-5-phosphatase D	Homo sapiens	171-175
21138418-0	2011	Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking and cellular localization in the submandibular gland of rats.	Water	67-72	aquaporin 5	Rattus norvegicus	55-59
21138418-8	2011	Using the Xenopus oocyte system, we demonstrated the mutant AQP5 to have water permeability almost the same as that of the wt molecule.	Water	73-78	aquaporin 5	Rattus norvegicus	60-64
21083571-7	2011	From 24 to 120 h, Save, industrialized coconut water and tap water were the worst storage media.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
20881307-11	2011	IL-17A and IL-17F were significantly higher in the eyes of EAU-induced mice at day 7.	Water	59-62	interleukin 17A	Mus musculus	0-6
20881307-17	2011	The possibility that miRNAs can affect IL-17 suggests that miRNAs in the retina regulate the development of EAU.	Water	108-111	interleukin 17A	Mus musculus	39-44
21298782-7	2011	The method was successfully applied to analyses of lake and tap water samples, and the relative recoveries of target analytes from the spiked lake and tap water samples were 92.8-106.3 and 93.6-105.6%, respectively.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
21298782-7	2011	The method was successfully applied to analyses of lake and tap water samples, and the relative recoveries of target analytes from the spiked lake and tap water samples were 92.8-106.3 and 93.6-105.6%, respectively.	Water	155-160	nuclear RNA export factor 1	Homo sapiens	151-154
20494560-4	2011	Recently, a specific IgG against NMO, designated NMO-IgG, was discovered, and the relevant antigen was found to be aquaporin-4 (AQP4), one of the major water channel proteins in the CNS.	Water	152-157	aquaporin 4	Homo sapiens	115-126
20494560-4	2011	Recently, a specific IgG against NMO, designated NMO-IgG, was discovered, and the relevant antigen was found to be aquaporin-4 (AQP4), one of the major water channel proteins in the CNS.	Water	152-157	aquaporin 4	Homo sapiens	128-132
21187412-1	2011	Aquaporin-4 (AQP4) is a primary influx route for water during brain edema formation.	Water	49-54	aquaporin 4	Homo sapiens	0-11
21187412-1	2011	Aquaporin-4 (AQP4) is a primary influx route for water during brain edema formation.	Water	49-54	aquaporin 4	Homo sapiens	13-17
21187412-6	2011	Our results suggest that AQP4 not only serves as an influx route for water but also is critical for initiating downstream signaling events that may affect and potentially exacerbate the pathological outcome in clinical conditions associated with brain edema.	Water	69-74	aquaporin 4	Homo sapiens	25-29
20934410-1	2011	Aquaporin-4 (AQP4), the prominent water channel in the brain, is particularly concentrated in astrocytic endfeet membranes lining the capillaries and the pia.	Water	34-39	aquaporin 4	Homo sapiens	0-11
20934410-1	2011	Aquaporin-4 (AQP4), the prominent water channel in the brain, is particularly concentrated in astrocytic endfeet membranes lining the capillaries and the pia.	Water	34-39	aquaporin 4	Homo sapiens	13-17
20934410-7	2011	As the efficiency of AQP4 in regulating water and ion homeostasis in extracellular space depends on its spatial distribution in astrocytes, the different distribution of AQP4 protein in the FCD type IIB samples may modify fluid homeostasis control and the regular functioning of neuronal cells.	Water	40-45	aquaporin 4	Homo sapiens	21-25
21102557-2	2011	The presence of large, water-filled pores with uncontrolled ion permeability, as formed by Sec61 complexes in the ER membrane, would seriously interfere with the regulated release of calcium from the ER lumen into the cytosol, an essential mechanism for intracellular signalling.	Water	23-28	SEC61 translocon subunit alpha 1	Homo sapiens	91-96
21190671-2	2011	By using synchrotron x-ray diffraction at high pressure in a diamond anvil cell we determined the bulk modulus of TTR105-115 amyloid fibrils in water and in silicone oil to be 2.6 and 8.1 GPa, respectively.	Water	144-149	transthyretin	Homo sapiens	114-117
24839332-2	2011	Viscosity of water improves confinement and extends the range of the trap parameters which characterize the stability of the trap.	Water	13-18	TRAP	Homo sapiens	69-73
24839332-2	2011	Viscosity of water improves confinement and extends the range of the trap parameters which characterize the stability of the trap.	Water	13-18	TRAP	Homo sapiens	125-129
21036918-4	2011	This was also the case in human blood CD8(+) cells exposed to water-soluble tobacco smoke components in vitro, in which oxidized proteins were markedly increased.	Water	62-67	CD8a molecule	Homo sapiens	38-41
21036918-5	2011	Extracellular IL-16 protein was increased in cell-free BAL fluid from chronic smokers and in human blood CD8(+) cells exposed to water-soluble tobacco smoke components in vitro.	Water	129-134	CD8a molecule	Homo sapiens	105-108
21036918-7	2011	A marker of activation (CD69) was slightly increased, whereas other markers of key cellular functions (membrane integrity, apoptosis, and proliferation) in human blood CD8(+) cells in vitro were negatively affected by water-soluble tobacco smoke components.	Water	218-223	CD8a molecule	Homo sapiens	168-171
21666364-0	2011	Oxidation of chromium(III) by free chlorine in tap water during the chlorination process studied by an improved solid-phase spectrometry.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
21666364-1	2011	The oxidation of Cr(III) at naturally-occurring concentration levels, i.e., microg dm(-3) or lower levels, by free chlorine during the chlorination process of tap water was studied using an improved solid-phase spectrophotometric method, which can be directly applicable to the specific determination of Cr(VI) at microg dm(-3) or lower levels.	Water	163-168	nuclear RNA export factor 1	Homo sapiens	159-162
21532156-1	2011	Allylmercapto glutathione S-conjugate, S-allylmercapto-L-cysteine (SAMC), which is biotransformed from allyl sulfides and from naturally occurring water-soluble garlic derivatives, has been known to inhibit tumorigenesis.	Water	147-152	solute carrier family 25 member 26	Homo sapiens	39-65
21532156-1	2011	Allylmercapto glutathione S-conjugate, S-allylmercapto-L-cysteine (SAMC), which is biotransformed from allyl sulfides and from naturally occurring water-soluble garlic derivatives, has been known to inhibit tumorigenesis.	Water	147-152	solute carrier family 25 member 26	Homo sapiens	67-71
22178885-1	2011	Uroguanylin (UGN) has been proposed as a key regulator of salt and water intestinal transport.	Water	67-72	guanylate cyclase activator 2B	Homo sapiens	0-11
22178885-1	2011	Uroguanylin (UGN) has been proposed as a key regulator of salt and water intestinal transport.	Water	67-72	guanylate cyclase activator 2B	Homo sapiens	13-16
22178885-2	2011	Uroguanylin activates cell-surface guanylate cyclase C receptor (GC-C) and modulates cellular function via cyclic GMP (cGMP), thus increasing electrolyte and net water secretion.	Water	162-167	guanylate cyclase activator 2B	Homo sapiens	0-11
21678774-1	2011	Recent STM experiments show that by exposing h-BN/Rh(111) nanomesh to water or atomic hydrogen interesting phenomena can be observed.	Water	70-75	sulfotransferase family 1A member 3	Homo sapiens	7-10
21678774-4	2011	For example, we could determine that the frequently observed three protrusions within the pore appearing in STM images obtained after dosing small amounts of water, are most likely determined by water hexamers.	Water	158-163	sulfotransferase family 1A member 3	Homo sapiens	108-111
21678774-4	2011	For example, we could determine that the frequently observed three protrusions within the pore appearing in STM images obtained after dosing small amounts of water, are most likely determined by water hexamers.	Water	195-200	sulfotransferase family 1A member 3	Homo sapiens	108-111
20846002-5	2011	Also, both complexes can cleave pBR-322 DNA in the presence of H(2)O(2), and [Cr(PIP)(2)Cl(2)](+) exhibits more effective activity than [Cr(IP)(2)Cl(2)](+) under the same condition.	Water	63-68	translocator protein	Homo sapiens	32-35
20855239-8	2011	RESULTS: The median MnW in children"s home tap water was 34 microg/L (range, 1-2,700 microg/L).	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
22022303-6	2011	RESULTS: Simulating the replacement of SSBs with tap water at 25, 50, and 100% levels resulted in 1-, 2.3-, and 3.8-point increases, respectively, in the HEI-2005 total score.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
22022303-7	2011	Based on a mean daily intake of 2,011 kcal, 100% substitution of SSBs with tap water would result in 11% reduction in energy intake.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
22038226-9	2011	Indeed, the lowest AQP5 immunoreactivity was noticed when food water content increased.	Water	63-68	aquaporin-5	Ovis aries	19-23
20951725-0	2011	Microwave assisted synthesis of polyacrylamide grafted starch (St-g-PAM) and its applicability as flocculant for water treatment.	Water	113-118	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	68-71
22432265-5	2011	The water quality also impacted the inactivation efficiencies, and rotaviruses have a relatively higher resistant in secondary effluents than in the tap water under the same chlorine disinfection treatments.	Water	153-158	nuclear RNA export factor 1	Homo sapiens	149-152
22219644-2	2011	METHODS: EAU was induced in B10.RIII mice by subcutaneous injection of interphotoreceptor retinoid-binding protein (IRBP) 161-180 emulsified with complete Freund"s adjuvant and evaluated with clinical and histopathologic observation.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	71-114
22219644-2	2011	METHODS: EAU was induced in B10.RIII mice by subcutaneous injection of interphotoreceptor retinoid-binding protein (IRBP) 161-180 emulsified with complete Freund"s adjuvant and evaluated with clinical and histopathologic observation.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	116-120
22053184-8	2011	Thus, over-expression of endothelial ET-1 in TET-1 mice may contribute to increased glutamate-induced neurotoxicity on neuronal cells and water accumulation in inner retina leading to edema.	Water	138-143	tet methylcytosine dioxygenase 1	Mus musculus	45-50
21969862-16	2011	However, expression of LdAQP1 and LdAQP putative in a yeast gpd1Delta strain, deleted for glycerol production, conferred osmosensitive phenotype indicating water transport activity or aquaporin function.	Water	156-161	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	60-64
21090792-3	2010	In particular, the influence of the choice of solvation model, protein force field, and water potential on the stability and dynamic properties of the c-Fos-c-Jun complex were investigated.	Water	88-93	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	151-156
21090792-4	2010	Use of the AMBER polarizable force field ff02 in combination with the polarizable POL3 water potential was found to result in increased stability of the c-Fos-c-Jun complex.	Water	87-92	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	153-158
21090792-4	2010	Use of the AMBER polarizable force field ff02 in combination with the polarizable POL3 water potential was found to result in increased stability of the c-Fos-c-Jun complex.	Water	87-92	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-164
21126042-7	2010	Furthermore, in contrast to the results obtained for the SyB(GAF), the MD simulations showed a very stable Cph1 structure where an important hydrogen bond and water network in the chromophore binding pocket could be identified.	Water	159-164	fibroblast growth factor 9	Homo sapiens	61-64
21090606-3	2010	This study investigates the intake of perchlorate, nitrate, and iodide attributable to direct and indirect tap water consumption.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
21090606-8	2010	On the basis of 24 h recall, 47% of the study participants reported drinking tap water; 89% reported either direct or indirect consumption of tap water.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
21090606-8	2010	On the basis of 24 h recall, 47% of the study participants reported drinking tap water; 89% reported either direct or indirect consumption of tap water.	Water	146-151	nuclear RNA export factor 1	Homo sapiens	142-145
21090606-9	2010	For the adult population (age &gt;= 20 yrs) the median tap water consumption rate was 11.6 mL/kg-day.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
21090606-10	2010	Using individual tap water consumption data and body weight, we estimated the median perchlorate, nitrate, and iodide dose attributable to tap water as 9.11, 11300, and 43.3 ng/kg-day, respectively, for U.S. adults.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
21090606-11	2010	This perchlorate exposure dose from tap water is relatively small compared to the total perchlorate exposure dose previously characterized for the U.S. adults (median 64 ng/kg-day) and the U.S. EPA reference dose (700 ng/kg-day).	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
21111188-0	2010	A two-photon excited luminescence of water-soluble rhodamine-platinum(II) complex: fluorescent probe specific for Hg2+ detection in live cell.	Water	37-42	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	114-117
21111190-7	2010	Prior to loading the water sample it was subjected to a simple derivatization procedure with 4-AAP.	Water	21-26	serpin family F member 2	Homo sapiens	95-98
21111190-9	2010	Method 2 was able to detect the presence of 2-CP-4-AAP in unspiked real water samples and almost full spike recovery was achieved.	Water	72-77	serpin family F member 2	Homo sapiens	51-54
21054786-10	2010	In PRTFDC1, a water molecule at the position of the aspartic acid side chain position in HPRT might be responsible for the low activity observed by acting as a weak base.	Water	14-19	phosphoribosyl transferase domain containing 1	Homo sapiens	3-10
20817699-1	2010	BACKGROUND: Households in dual reticulation developments are supplied with recycled water from sewage effluent for some non-potable purposes, and conventional tap water for other uses.	Water	163-168	nuclear RNA export factor 1	Homo sapiens	159-162
21044941-3	2010	We present a typical case, where orthostatic hemodynamic response was significantly improved by ingestion of 500 ml tap water.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
20887994-2	2010	In this approach, tri-n-butylphosphate (TBP), a Lewis base, was directly used, instead of the traditional water-immiscible organic solvents, as the extractant for DLLME.	Water	106-111	TATA-box binding protein	Homo sapiens	40-43
20966958-0	2010	Catalytic enantioselective syn hydration of enones in water using a DNA-based catalyst.	Water	54-59	synemin	Homo sapiens	27-30
21921483-2	2010	A crucial role for humoral immunity in the NMO pathogenesis has been suggested by the detection of a highly specific serum autoantibody NMO immunoglobulin G that binds to aquaporin-4 (AQP4) water channels, and the pronounced deposition of immunoglobulins colocalizing with products of complement activation in a vasculocentric pattern around thickened hyalinized blood vessels in NMO lesions.	Water	190-195	aquaporin 4	Homo sapiens	184-188
20853818-6	2010	The donor chain length limit of C10 coincides with the phosphatidylcholine transition from displaying bilayer to micellar properties in water, but the detergent inhibitor lauryldimethylamine N-oxide also gradually became ineffective in a micellar assay as the selected acyl chains were shortened to C10.	Water	136-141	chromosome 12 open reading frame 57	Homo sapiens	32-35
20688912-4	2010	After increasing the membrane cholesterol content by treatment of water-soluble cholesterol (cholesterol mixed with methyl-beta-cyclodextrin), we observed an increase in DAT binding B(max) values for cocaine analogs [(3)H]WIN35428 and [(125)I]RTI-55, but similar levels of DAT proteins on the cell surface were shown by surface biotinylation assays.	Water	66-71	solute carrier family 6 member 3	Homo sapiens	170-173
20688912-4	2010	After increasing the membrane cholesterol content by treatment of water-soluble cholesterol (cholesterol mixed with methyl-beta-cyclodextrin), we observed an increase in DAT binding B(max) values for cocaine analogs [(3)H]WIN35428 and [(125)I]RTI-55, but similar levels of DAT proteins on the cell surface were shown by surface biotinylation assays.	Water	66-71	solute carrier family 6 member 3	Homo sapiens	273-276
20875589-8	2010	Tap water, sea water and mineral water samples were successfully analyzed for the existence of chlorophenols using the proposed method.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
20639120-9	2010	High doses of H(2)O(2) inhibit while low doses of H(2)O(2) activate mTORC1 both in TSC2(-/-) P53(-/-) and TSC2(+/+) P53(-/-) MEFs.	Water	14-19	TSC complex subunit 2	Homo sapiens	83-87
20639120-9	2010	High doses of H(2)O(2) inhibit while low doses of H(2)O(2) activate mTORC1 both in TSC2(-/-) P53(-/-) and TSC2(+/+) P53(-/-) MEFs.	Water	14-19	TSC complex subunit 2	Homo sapiens	106-110
20689062-5	2010	Adeno-associated virus (AAV)-mediated overexpression of human PRR in the SON of normal rats resulted in increases in plasma and urine vasopressin, and decreases in H(2)O intake and urine output without any effects on mean arterial pressure and heart rate.	Water	164-169	ATPase H+ transporting accessory protein 2	Homo sapiens	62-65
20637868-1	2010	The capability of transglycosylated materials, alpha-glycosyltransferase-treated stevia (Stevia-G) and alpha-glycosyl hesperidin (Hsp-G), to enhance the bioavailability of poorly water-soluble drugs was investigated.	Water	179-184	syndecan 2	Homo sapiens	130-135
20633688-12	2010	Expression of Runx2 was upregulated by Ox-LDL and H(2)O(2), and these effects were suppressed by NAC pretreatment.	Water	50-55	RUNX family transcription factor 2	Bos taurus	14-19
20860832-4	2010	In recent times aquaporin 4, the most abundant aquaporin within the brain itself, which has also been shown to have a role in brain water physiology and relevance to brain oedema in trauma and tumours, has become an alternative focus of attention for hydrocephalus research.	Water	132-137	aquaporin 4	Homo sapiens	16-27
20729876-5	2010	However, KOR agonists also produce several severe undesirable side effects such as dysphoria, water diuresis, salivation, emesis, and sedation in nonhuman primates, which may limit the clinical utility of KOR agonists for pain and drug abuse treatment.	Water	94-99	opioid receptor kappa 1	Homo sapiens	9-12
20840409-12	2010	Wetting surgical wounds with clean tap water does not increase, and may even reduce, wound infection rate.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
20045595-4	2010	Hot tap water scald cases for 1999-2007 were identified from hospitalisation data for all public and private hospitals in NSW.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
20045595-5	2010	To investigate hot tap water scald hospitalisations over time, negative binomial regression analysis was performed.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
20045595-6	2010	There were 845 hospitalisations for hot tap water scalds in NSW over the period of the study.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
20045595-7	2010	Hospital admission rates for hot tap water scalds decreased by an estimated 6% (3.2-8.5, 95%CI) per year since the introduction of regulations.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
20639139-6	2010	i.c.v.-Abeta resulted in significant behavioral alterations suggesting Alzheimer"s disease, where there was significant impairment in spatial cognition, evaluated by Morris water maze task, and in learning and memory performance, assessed using passive-avoidance learning task.	Water	173-178	amyloid beta precursor protein	Rattus norvegicus	7-12
20827751-3	2010	In this report, a conditional expression model (Tet-On system) was used to down-regulate podocyte VEGF in adult mice, which resulted in many kidney problems, characterized by glomerular morphological changes, proteinuria, reduced water consumption and urination, increased urine electro-conductivity, as well as high susceptibility to BSA stress.	Water	230-235	vascular endothelial growth factor A	Mus musculus	98-102
20663694-6	2010	However, the approach of such a structural water molecule to the active-site ferrous ion is prohibited in the FIH1-NODP complex, which should be attributed to the formation of hydrophobic contacts between the phenyl ring of the inhibitor and the side chains of Tyr102, Leu186, and Trp296 at the entrance of the active site.	Water	43-48	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	110-114
20600429-7	2010	Thus, we propose that the novel Y4 receptor agonist BVD-74D has suppressive effects on food intake, water intake, and weight gain in normal mice fed with normal diets and on food intake in normal mice fed with high-fat diets and in FLS-ob/ob mice.	Water	100-105	neuropeptide Y receptor Y4	Mus musculus	32-43
21179621-6	2010	DNMO is now considered to be an autoimmune, antibody-mediated disease especially since the identification of a specific serum autoantibody, named NMO-IgG and directed against the main water channel of the CNS, aquaporin-4 (AQP4).	Water	184-189	aquaporin 4	Homo sapiens	210-221
20797619-4	2010	Inhibition of the histone acetyltransferase (HAT) activity of p300 by a water-soluble, small molecule inhibitor, Hydrazinocurcumin (CTK7A), substantially reduced the xenografted oral tumor growth in mice.	Water	72-77	E1A binding protein p300	Mus musculus	62-66
20865057-6	2010	Water penetration and solvent accessibility calculations show that TM1, TM3, TM6 and TM8 line the substrate binding/unbinding pathway with TM10 and its pseudosymmetric partner, TM5, participating in the extracellular and intracellular halves of the lumen, respectively.	Water	0-5	tropomyosin 3	Homo sapiens	72-75
20865057-6	2010	Water penetration and solvent accessibility calculations show that TM1, TM3, TM6 and TM8 line the substrate binding/unbinding pathway with TM10 and its pseudosymmetric partner, TM5, participating in the extracellular and intracellular halves of the lumen, respectively.	Water	0-5	tetraspanin 16	Homo sapiens	85-88
20865057-6	2010	Water penetration and solvent accessibility calculations show that TM1, TM3, TM6 and TM8 line the substrate binding/unbinding pathway with TM10 and its pseudosymmetric partner, TM5, participating in the extracellular and intracellular halves of the lumen, respectively.	Water	0-5	tropomyosin 3	Homo sapiens	177-180
20632335-2	2010	Subjection of the syn diastereomers to NAC-gold catalysts (NAC=nitrogen acyclic carbene) in the presence of external nucleophiles such as water or anilines provided substituted and highly rigid heterocyclic cages.	Water	138-143	synemin	Homo sapiens	18-21
20547053-7	2010	UV-vis spectrophotometric determination of the GOx remains in the supernatant liquids after pH-induced CS precipitation suggested a high enzyme load in the GOx-GA-CS film, and amperometric measurements suggested a negligible decrease in the enzymatic activity of GOx after its reaction with the low-concentration GA. Also, the proposed protocol works well for the precrosslinking manner of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide/N-hydroxysulfosuccinimide activation, the water-electroreduction-triggered CS electrodeposition, the second-generation biosensing mode, a 5.0-microm-radius Pt ultramicroelectrode, and immobilization of alkaline phosphatase for phenyl phosphate biosensing.	Water	479-484	hydroxyacid oxidase 1	Homo sapiens	47-50
20572169-3	2010	The reaction mechanism has been largely debated in the literature; two modes for the nucleophilic addition of water to a Pd-coordinated alkene have been proposed: syn-inner- and anti-outer-sphere mechanisms.	Water	110-115	synemin	Homo sapiens	163-166
20666478-2	2010	In order to achieve a controlled enzyme electrode and waveguide mode, GO(x) (negatively charged) was immobilized with a water-soluble, conducting N-alkylaminated polypyrrole (positively charged) using the layer-by-layer (LbL) electrostatic self-assembly technique.	Water	120-125	hydroxyacid oxidase 1	Homo sapiens	70-75
20452023-0	2010	Simultaneous determination and assessment of 4-nonylphenol, bisphenol A and triclosan in tap water, bottled water and baby bottles.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
20452023-1	2010	This study investigated the levels of 4-nonylphenol (4-NP), bisphenol A (BPA) and triclosan (TCS) in bottled water and tap water in Guangzhou and release of these chemicals from baby bottles using gas chromatography-mass spectrometry with negative chemical ionization.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
20452023-4	2010	Five of the tap water samples from six drinking water plants were found to contain 4-NP and BPA both in June and December, while TCS was detected in the same five plants only in June.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
20452023-5	2010	The highest concentrations in tap water for 4-NP, BPA and TCS were 1987, 317 and 14.5ng/L, respectively.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
20452023-6	2010	Daily intakes of 4-NP, BPA and TCS of adults by drinking 2L of tap water were estimated to be 1410, 148 and 10 ng/day, respectively.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
20458553-3	2010	Recently, bumetanide has been shown to also inhibit water permeability via aquaporin-4 (AQP4) expressed in Xenopus laevis oocytes.	Water	52-57	aquaporin 4 L homeolog	Xenopus laevis	75-86
20458553-3	2010	Recently, bumetanide has been shown to also inhibit water permeability via aquaporin-4 (AQP4) expressed in Xenopus laevis oocytes.	Water	52-57	aquaporin 4 L homeolog	Xenopus laevis	88-92
20107809-3	2010	PATIENTS AND METHOD: For a total of 100 patients a routine examination glove was filled with 350 ml of warm tap water and after injection placed for 10 min on the eye scheduled for surgery.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
20504772-7	2010	By protein cross-linking using water-soluble and membrane-impermeable cross-linker bis(sulfosuccinimidyl) suberate and nondenaturing gels, we show that RAGE forms homodimers at the plasma membrane, a process potentiated by S100B and advanced glycation end products.	Water	31-36	advanced glycosylation end-product specific receptor	Homo sapiens	152-156
20650003-13	2010	CONCLUSION: Replacement of the RDT kit"s dedicated buffer by saline, distilled water and tap water can cause false-positive test results.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
20598552-4	2010	An X-ray crystal structure of hCA II in complex with 4-(7-methoxy-coumarin-4-yl-acetamido)-benzenesulfonamide (KI of 9.1 nM against hCA II) showed the intact inhibitor coordinated to the zinc ion from the enzyme active site by the sulfonamide moiety, and participating in a edge-to-face stacking with Phe131, in addition to other hydrophobic and hydrophilic interactions with water molecules and amino acid residues from the active site.	Water	376-381	carbonic anhydrase 2	Homo sapiens	30-36
20598552-4	2010	An X-ray crystal structure of hCA II in complex with 4-(7-methoxy-coumarin-4-yl-acetamido)-benzenesulfonamide (KI of 9.1 nM against hCA II) showed the intact inhibitor coordinated to the zinc ion from the enzyme active site by the sulfonamide moiety, and participating in a edge-to-face stacking with Phe131, in addition to other hydrophobic and hydrophilic interactions with water molecules and amino acid residues from the active site.	Water	376-381	carbonic anhydrase 2	Homo sapiens	132-138
20164461-5	2010	EAU was induced in Lewis rats by subcutaneous injection of interphotoreceptor retinoid-binding protein R16 peptide emulsified in adjuvant.	Water	0-3	ribonuclease 16-like	Rattus norvegicus	103-106
20499933-3	2010	Tap water delta(2)H and delta(18)O values were strongly correlated with the stable isotope ratios of bottled water and soda purchased in the same location.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
20499933-3	2010	Tap water delta(2)H and delta(18)O values were strongly correlated with the stable isotope ratios of bottled water and soda purchased in the same location.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	0-3
20499933-4	2010	Beer water delta(2)H and delta(18)O values were also correlated with tap water, although not as strongly.	Water	5-10	nuclear RNA export factor 1	Homo sapiens	69-72
20499933-6	2010	It was concluded that the isotopic composition of local tap water is a reasonable proxy for consumers" fluid intake in most U.S. cities.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
20685419-6	2010	Based on a signal to noise ratio of 3, the detection limits were 0.75 nM for the tap water and 12.0 nmol kg(-1) for the soil.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
20685419-7	2010	The method showed good recoveries and precision, 93.4% (RSD 1.5%, n=3) for 100 mL of tap water spiked with 2.0 nmol and 81.3% (RSD 2.6%, n=3) for 10 g of soil spiked with 0.80 nmol, suggesting that the imprinted stir bar can be successfully applied to the preconcentration of nicosulfuron in real samples.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
20386792-1	2010	H-Phosphinic acid and pyruvic acid, both plausible prebiotic chemicals, react selectively in water to build structural complexity including amide bond formation under remarkably mild conditions and oxidative coupling of P(1) compounds to condensed pyrophosphorus compounds.	Water	93-98	crystallin gamma F, pseudogene	Homo sapiens	220-224
20572856-1	2010	The water channel aquaporin 5 (AQP5) seems to play a key role in salivary fluid secretion and appears to be critical in the cell volume regulation of acinar cells.	Water	4-9	aquaporin 5	Rattus norvegicus	31-35
20455256-1	2010	Water channel aquaporin 5 (AQP5) is highly expressed at the apical membrane of alveolar type I epithelial cells and confers high osmotic water permeability.	Water	0-5	aquaporin 5	Mus musculus	14-25
20455256-1	2010	Water channel aquaporin 5 (AQP5) is highly expressed at the apical membrane of alveolar type I epithelial cells and confers high osmotic water permeability.	Water	0-5	aquaporin 5	Mus musculus	27-31
20455256-1	2010	Water channel aquaporin 5 (AQP5) is highly expressed at the apical membrane of alveolar type I epithelial cells and confers high osmotic water permeability.	Water	137-142	aquaporin 5	Mus musculus	14-25
20455256-1	2010	Water channel aquaporin 5 (AQP5) is highly expressed at the apical membrane of alveolar type I epithelial cells and confers high osmotic water permeability.	Water	137-142	aquaporin 5	Mus musculus	27-31
20546838-0	2010	Source and occurrence of particulate lead in tap water.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
20577926-12	2010	CONCLUSION: High expression of AQP4 accelerates the water absorption in colon mucosa and may be one of the crucial events in the development of STC.	Water	52-57	aquaporin 4	Homo sapiens	31-35
20531944-9	2010	Rats given 100 ppm F(-) in their drinking water exhibited increased stress-mediated phosphorylation of eIF2alpha in maturation stage ameloblasts (pH&lt;6.0) as compared to secretory stage ameloblasts (pH approximately 7.2).	Water	42-47	eukaryotic translation initiation factor 2A	Rattus norvegicus	103-112
20225272-10	2010	However, the mutant protein was less protective relative to the wild-type protein in preventing caspase-3 and caspase-9 activation and apoptosis induced by 1 mM H(2)O(2) in CHO and HeLa cells.	Water	161-166	caspase-9	Cricetulus griseus	110-119
20465833-8	2010	The results reveal that Cry4Aa toxins use polar amino acid residues on alpha-helices 3, 4, and 6 to form trimer and suggest that the proteins form trimer to reduce their non-polar interactions with surrounding water.	Water	210-215	cry4AA	Bacillus thuringiensis serovar israelensis	24-30
20306188-1	2010	Pyrroquinoline quinone-dependent alcohol dehydrogenase (PQQ-ADH) of acetic acid bacteria is a membrane-bound enzyme involved in the acetic acid fermentation by oxidizing ethanol to acetaldehyde coupling with reduction of membranous ubiquinone (Q), which is, in turn, re-oxidized by ubiquinol oxidase, reducing oxygen to water.	Water	320-325	aldo-keto reductase family 1 member A1	Homo sapiens	33-54
20842585-3	2010	In a high proportion of recognized cases of NMO, there is a highly specific autoantibody (NMO-IgG), which is directed to the common central nervous system water channel, aquaporin-4.	Water	155-160	aquaporin 4	Homo sapiens	170-181
21787604-2	2010	From the results of the study, the hazard quotient for oral ingestion of mercury in tap water in Obuasi is 7.4 and 15 respectively via both central tendency exposure (CTE) and reasonable maximum exposure (RME) parameters, respectively.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
19856254-1	2010	AIM: Insulin promotes ion transportation across epithelia, mainly kidneys, leading to water and electrolyte abnormalities, possibly causing "insulin oedema syndrome", which rarely presents as pleural effusion.	Water	86-91	LOC105613195	Ovis aries	5-12
20423460-5	2010	CD spectra showed that EA-CATH1 mainly adopts an alpha-helical conformation in a 50% trifluoroethanol/water solution, but a random coil in aqueous solution.	Water	102-107	cathelin	Equus asinus	26-31
19937457-9	2010	Balneotherapy with the thermal water from Hajduszoboszlo spa had a more pronounced physiological effect compared to that seen in the control group treated with tap water in a 3 month period.	Water	31-36	surfactant protein A2	Homo sapiens	57-60
19937457-9	2010	Balneotherapy with the thermal water from Hajduszoboszlo spa had a more pronounced physiological effect compared to that seen in the control group treated with tap water in a 3 month period.	Water	164-169	surfactant protein A2	Homo sapiens	57-60
19937457-9	2010	Balneotherapy with the thermal water from Hajduszoboszlo spa had a more pronounced physiological effect compared to that seen in the control group treated with tap water in a 3 month period.	Water	164-169	nuclear RNA export factor 1	Homo sapiens	160-163
20183853-3	2010	Four kinase systems (Src family, Abl/c-Kit, Syk/ZAP-70, and CDK2/4) were investigated, and differences in predicted water molecule locations and energetics were able to explain the experimentally observed binding selectivity profiles.	Water	116-121	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	33-36
20183853-3	2010	Four kinase systems (Src family, Abl/c-Kit, Syk/ZAP-70, and CDK2/4) were investigated, and differences in predicted water molecule locations and energetics were able to explain the experimentally observed binding selectivity profiles.	Water	116-121	spleen associated tyrosine kinase	Homo sapiens	44-47
20183853-3	2010	Four kinase systems (Src family, Abl/c-Kit, Syk/ZAP-70, and CDK2/4) were investigated, and differences in predicted water molecule locations and energetics were able to explain the experimentally observed binding selectivity profiles.	Water	116-121	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	48-54
20174984-9	2010	Recovery studies applied to the determination of mercuric ions in bottled and tap water samples were in the 92-104% range.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
20180641-0	2010	Increased blood pressure and water intake in transgenic mice expressing rat tonin in the brain.	Water	29-34	kallikrein 1-related peptidase C2	Rattus norvegicus	76-81
20618130-3	2010	Partial correlation between hydration intervals can be considered as evidence of correlation between mobility of non-water proton-containing groups with proton relaxation frequency approximately 10(8) sec(-1) with efficiency of electron transfer at the donor side of the chain.	Water	117-122	secretory blood group 1, pseudogene	Homo sapiens	201-207
20049913-1	2010	A water-soluble alpha-(1--&gt;4)-D-glucan heteropolysaccharide with 37% degree of branch extracted by base from Rhizoma Panacis Japonici, coded as RPS3, was fractionated into six fractions by the method of nonsolvent addition.	Water	2-7	ribosomal protein S3	Homo sapiens	147-151
20049913-6	2010	Transmission electron microscope further provided the evidence of the sphere shape of the RPS3 and its fractionated molecules in water.	Water	129-134	ribosomal protein S3	Homo sapiens	90-94
20138100-0	2010	Beyond water channel: aquaporin-4 in adult neurogenesis.	Water	7-12	aquaporin 4	Homo sapiens	22-33
20138100-1	2010	Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored.	Water	53-58	aquaporin 4	Homo sapiens	0-11
20138100-1	2010	Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored.	Water	53-58	aquaporin 4	Homo sapiens	13-17
19904957-1	2010	Water sorption isotherms of proteins are usually interpreted with such models as BET or GAB that imply the formation of multilayers at solid-gas interface.	Water	0-5	alpha-1-B glycoprotein	Homo sapiens	88-91
20377303-7	2010	The HET-CAM assay was sufficiently specific (few FP) for water-soluble substances, but failed to identify nearly all the severe irritants within this group.	Water	57-62	calmodulin	Oryctolagus cuniculus	8-11
20141152-0	2010	Fluorescent carrier ampholytes assay for portable, label-free detection of chemical toxins in tap water.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
20141152-8	2010	We then present the integration of the technique into a self-contained hand-held device and demonstrate detection of chemical toxins (2-nitrophenol and 2,4,6-trichlorophenol) in tap water, with no sample preparation steps.	Water	182-187	nuclear RNA export factor 1	Homo sapiens	178-181
20013023-0	2010	Differential water permeability and regulation of three aquaporin 4 isoforms.	Water	13-18	aquaporin 4 L homeolog	Xenopus laevis	56-67
20013023-1	2010	Aquaporin 4 (AQP4) is expressed in the perivascular glial endfeet and is an important pathway for water during formation and resolution of brain edema.	Water	98-103	aquaporin 4 L homeolog	Xenopus laevis	0-11
20013023-1	2010	Aquaporin 4 (AQP4) is expressed in the perivascular glial endfeet and is an important pathway for water during formation and resolution of brain edema.	Water	98-103	aquaporin 4 L homeolog	Xenopus laevis	13-17
20013023-2	2010	In this study, we examined the functional properties and relative unit water permeability of three functional isoforms of AQP4 expressed in the brain (M1, M23, Mz).	Water	71-76	aquaporin 4 L homeolog	Xenopus laevis	122-126
20013023-6	2010	Upon protein kinase C (PKC) activation, oocytes expressing the three isoforms demonstrated rapid reduction of water permeability, which correlated with AQP4 internalization.	Water	110-115	aquaporin 4 L homeolog	Xenopus laevis	152-156
20220445-13	2010	CONCLUSIONS: Hot water epilepsy is a benign reflex epilepsy.	Water	17-22	alcohol dehydrogenase iron containing 1	Homo sapiens	13-16
20061449-8	2010	Activities of the water-extractable enzymes oxalate oxidase, peroxidase, and polyphenol oxidase were highest in the outer layers, whereas chitinase activity was found only in assays of whole grains.	Water	18-23	germin-like protein 8-4	Triticum aestivum	44-59
20034631-9	2010	The proposed method was successfully applied to the quantitative analysis of the phenols in tap water, and proved to be a simple, convenient and reliable sample preconcentration and determination method for volatile analytes in water samples.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
20034631-9	2010	The proposed method was successfully applied to the quantitative analysis of the phenols in tap water, and proved to be a simple, convenient and reliable sample preconcentration and determination method for volatile analytes in water samples.	Water	228-233	nuclear RNA export factor 1	Homo sapiens	92-95
19931295-7	2010	Aryl hydrocarbon receptor (AhR) and B[alpha]P-related H(2)O(2) formation were involved in the reduced expression of HMG-CoA reductase and in the remodeling of membrane microdomains.	Water	54-59	aryl hydrocarbon receptor	Rattus norvegicus	0-25
19931295-7	2010	Aryl hydrocarbon receptor (AhR) and B[alpha]P-related H(2)O(2) formation were involved in the reduced expression of HMG-CoA reductase and in the remodeling of membrane microdomains.	Water	54-59	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	116-133
19937002-0	2010	Stripping analysis of heavy metals in tap water using the bismuth film electrode.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
19892397-1	2010	Contact activation of blood factor XII (FXII, Hageman factor) in neat-buffer solution exhibits a parabolic profile when scaled as a function of silanized-glass-particle activator surface energy (measured as advancing water adhesion tension tau(a)(o)=gamma(lv)(o)cos theta in dyne/cm, where gamma(lv)(o) is water interfacial tension in dyne/cm and theta is the advancing contact angle).	Water	217-222	coagulation factor XII	Homo sapiens	46-60
19892397-1	2010	Contact activation of blood factor XII (FXII, Hageman factor) in neat-buffer solution exhibits a parabolic profile when scaled as a function of silanized-glass-particle activator surface energy (measured as advancing water adhesion tension tau(a)(o)=gamma(lv)(o)cos theta in dyne/cm, where gamma(lv)(o) is water interfacial tension in dyne/cm and theta is the advancing contact angle).	Water	306-311	coagulation factor XII	Homo sapiens	46-60
19889792-6	2010	Furthermore, long-term 1-week administration of nicotine increased water content in hippocampal slices that could be attenuated with nicotine acetylcholine receptor (nAChR) antagonists, suggesting nicotine increase edema during OGD via nAChRs.	Water	67-72	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	133-164
19889792-6	2010	Furthermore, long-term 1-week administration of nicotine increased water content in hippocampal slices that could be attenuated with nicotine acetylcholine receptor (nAChR) antagonists, suggesting nicotine increase edema during OGD via nAChRs.	Water	67-72	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	166-171
19367471-1	2010	(1R,2R,3S,4R)-2-Amino-6,6-dimethylbicyclo[3.1.1]heptane-3-carboxylic acid 1 was reacted with three aldehydes and two isocyanides in methanol, in water, and under solvent-free conditions to prepare enantiomeric beta-lactams via U-4C-3CRs.	Water	145-150	mediator complex subunit 25	Homo sapiens	69-75
19548013-6	2010	COL25A1 mice displayed reduced anxiety-like behavior in elevated plus maze and open field tests and significantly slower swimming speed in Morris water maze.	Water	146-151	collagen, type XXV, alpha 1	Mus musculus	0-7
19937650-5	2010	Our simulations in explicit water allow the identification of events that clearly discriminate the unfolding behavior of WT and L55P-TTR.	Water	28-33	transthyretin	Homo sapiens	133-136
21994643-2	2010	The lack of CFTR activity brings a dysregulated exchange of ions and water through the airway epithelium, one of the main aspects of CF lung disease pathophysiology.	Water	69-74	cystic fibrosis transmembrane conductance regulator	Mus musculus	12-16
19906645-0	2010	Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.	Water	20-25	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	103-106
20503471-2	2010	In the in vitro study, we found the earthworm (EW) water extracts caused a marked enhancement of the nerve growth factor-mediated neurite outgrowth from PC12 cells as well as the expressions of growth associated protein 43 and synapsin I.	Water	51-56	synapsin I	Rattus norvegicus	227-237
20410571-7	2010	Good validation was obtained on applications of the two phases for the separation and determination of Ca(II) in natural water and pharmaceutical samples with no matrix interferences at pH 10.00 under dynamic conditions prior to determination by AAS.	Water	121-126	carbonic anhydrase 2	Homo sapiens	103-109
20467129-2	2010	Two types of PGA, gamma-polyglutamic acid (PGAH) and gamma-polyglutamic acid sodium salt (PGANa), were employed to prepare GOx immobilized film by the covalent attachment of GOx using water-soluble carbodiimide (EDC).	Water	184-189	hydroxyacid oxidase 1	Homo sapiens	123-126
20467129-2	2010	Two types of PGA, gamma-polyglutamic acid (PGAH) and gamma-polyglutamic acid sodium salt (PGANa), were employed to prepare GOx immobilized film by the covalent attachment of GOx using water-soluble carbodiimide (EDC).	Water	184-189	hydroxyacid oxidase 1	Homo sapiens	174-177
19545648-0	2010	2H and 13C NMR studies on the temperature-dependent water and protein dynamics in hydrated elastin, myoglobin and collagen.	Water	52-57	elastin	Homo sapiens	91-98
19545648-1	2010	(2)H NMR spin-lattice relaxation and line-shape analyses are performed to study the temperature-dependent dynamics of water in the hydration shells of myoglobin, elastin, and collagen.	Water	118-123	elastin	Homo sapiens	162-169
19864112-12	2010	CONCLUSION: Variations in the AQP4 and the KCNJ10/KCNJ9 region are likely to be associated with TLE, particularly TLE-FS, supporting the suggestion that perturbations of water and K(+) transport are involved in the etiopathogenesis of TLE.	Water	170-175	aquaporin 4	Homo sapiens	30-34
20329539-1	2010	The effect of copper ions on the water solubility enhancement of 4,4"- dibromodiphenyl ethers (BDE-15) by a commercial humic acid (HA) has been studied using batch equilibrium technique at various pHs.	Water	33-38	homeobox D13	Homo sapiens	95-98
20930427-8	2010	A defect of mitochondrial NDUFV1 may reduce complex I, which produces most of the superoxide, which is then scavenged by the mitochondrial enzyme Mn-superoxide dismutase to produce H(2)O(2).	Water	181-186	NADH:ubiquinone oxidoreductase core subunit V1	Homo sapiens	26-32
19696173-2	2010	METHODS: EAU was induced in B10RIII mice by immunization with IRBP(161-180) in complete Freund"s adjuvant and evaluated clinically and pathologically on days 0, 7, 14, 21, and 28.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	62-66
19696173-11	2010	Transfer of CD4(+)CD25(+) Treg cells obtained from EAU mice was able to suppress EAU induction by IRBP(161-180) that was not observed after transfer of cells from mice that had received CFA alone, suggesting antigen specificity of the Treg response.	Water	51-54	CD4 antigen	Mus musculus	12-15
19696173-11	2010	Transfer of CD4(+)CD25(+) Treg cells obtained from EAU mice was able to suppress EAU induction by IRBP(161-180) that was not observed after transfer of cells from mice that had received CFA alone, suggesting antigen specificity of the Treg response.	Water	51-54	retinol binding protein 3, interstitial	Mus musculus	98-102
27820507-29	2010	CONCLUSIONS: Current RCT evidence suggests the use of a surgical sterile catheterisation technique is not required, and that tap water is sufficient for cleaning genitalia.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
21576865-1	2010	Sulfur-turf microbial mats develop in sulfide-containing hot spring water dominated by chemolithoautotrophic sulfur-oxidizing bacteria.	Water	68-73	alcohol dehydrogenase iron containing 1	Homo sapiens	57-60
20128648-2	2010	METHODS: B10RIII mice were immunized with 50 microg IRBP(161-180) in complete Freund"s adjuvant (CFA) to induce EAU.	Water	112-115	retinol binding protein 3, interstitial	Mus musculus	52-56
20364683-2	2010	The data obtained made it possible for the first time to propose incorporation of drinking carbonate mineral water in the combined sanatorium-and-spa treatment of such patients.	Water	109-114	surfactant protein A2	Homo sapiens	146-149
21099055-1	2010	Geosmin and 2-methylisoborneol (2-MIB) are naturally occurring compounds responsible for musty-earthy-odors in surface water supplies.	Water	119-124	MIB E3 ubiquitin protein ligase 1	Homo sapiens	34-37
21123912-2	2010	MBR systems typically are constructed on a smaller footprint, and provide superior treated water quality.	Water	91-96	translocator protein	Homo sapiens	0-3
20057909-3	2009	METHODS: EAU was induced in B10.RIII mice by subcutaneous injection of interphotoreceptor retinoid-binding protein (IRBP) 161-180 emulsified with complete Freund"s adjuvant (CFA) and evaluated by clinical and histopathologic observation.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	71-114
19800950-4	2009	The water permeability of AQP4/V1(a)R-expressing oocytes was reduced in a vasopressin-dependent manner, as a result of V1(a)R-dependent internalization of AQP4.	Water	4-9	aquaporin 4 L homeolog	Xenopus laevis	26-30
19800950-4	2009	The water permeability of AQP4/V1(a)R-expressing oocytes was reduced in a vasopressin-dependent manner, as a result of V1(a)R-dependent internalization of AQP4.	Water	4-9	aquaporin 4 L homeolog	Xenopus laevis	155-159
20024422-0	2009	X-ray reflectometry studies on the effect of water on the surface structure of [C4mpyr][NTf2] ionic liquid.	Water	45-50	nuclear transport factor 2	Homo sapiens	88-92
19782659-0	2009	Damage to the central amygdala produces differential encephalic c-fos expression in the water deprivation-partial rehydration protocol.	Water	88-93	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-69
19924324-5	2009	Using XPS and STM we have investigated the formation of the CuCl(2) like surface species and propose that it derives from the unusual reactivity of transient copper adatoms released from the p(2 x 1)O by the exothermic formation of water.	Water	232-237	sulfotransferase family 1A member 3	Homo sapiens	14-17
19948131-1	2009	The shorter "M23" isoform of the glial cell water channel aquaporin-4 (AQP4) assembles into orthogonal arrays of particles (OAPs) in cell plasma membranes, whereas the full-length "M1" isoform does not.	Water	44-49	aquaporin 4	Homo sapiens	58-69
19948131-1	2009	The shorter "M23" isoform of the glial cell water channel aquaporin-4 (AQP4) assembles into orthogonal arrays of particles (OAPs) in cell plasma membranes, whereas the full-length "M1" isoform does not.	Water	44-49	aquaporin 4	Homo sapiens	71-75
19820158-6	2009	AlkB sequence diversity was lower in deep water (&gt;400 m) samples off the continental slope than in shallow water (&lt;100 m) samples on the continental shelf but not significantly different in response to levels of alkanes.	Water	42-47	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	0-4
19820158-6	2009	AlkB sequence diversity was lower in deep water (&gt;400 m) samples off the continental slope than in shallow water (&lt;100 m) samples on the continental shelf but not significantly different in response to levels of alkanes.	Water	110-115	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	0-4
19837845-0	2009	Temporal and spatial diversity of the tap water microbiota in a Norwegian hospital.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
19660937-4	2009	Using acidified or tap water caused considerable biogas losses and should therefore be avoided where biogas is stored before measurement.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
20055218-2	2009	In Japan, because the majority of HPC bacteria are supposed to be harmless and all tap water should maintain residual chlorine, there are few studies of the virulence of HPC bacteria.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
18998225-0	2009	Preliminary assessment of total dissolved trace metal concentrations in Sava River water.	Water	83-88	T-box transcription factor T	Homo sapiens	72-76
19707218-5	2009	Such an exacerbated condition in the GET-1 mice may be a result of a significant increase in cerebral water content and increased expression of the water channel protein, aquaporin 4 (AQP-4).	Water	102-107	activating transcription factor 7 interacting protein 2	Mus musculus	37-42
19707218-6	2009	The GET-1 mice treated with OPC-31260, a nonpeptide arginine vasopressin V(2) receptor antagonist, were alleviated from the cerebral water accumulation and neurologic deficit during the early time period after water intoxication.	Water	133-138	activating transcription factor 7 interacting protein 2	Mus musculus	4-9
19590130-2	2009	Therefore, since the margin between healthy intake and toxic intake is narrow, the selenium concentration of tap water is a parameter that must be monitored because of its potential for increased intake.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
19664809-9	2009	Tap water infusion at a flow rate of 10 L/h was infused through the arterial tubings controlled with a drip regulator filling the arterial tree and leaking into the interstitial and cisternal space.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
20016436-1	2009	A patient developed a prolonged respiratory illness after a single overnight use of tap water to humidify air supplied by a constant positive airway pressure (CPAP) device, which she had previously used for six years without difficulty.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
19514846-4	2009	Water content was also preserved in PRP-GHM-treated IVDs.	Water	0-5	major prion protein	Oryctolagus cuniculus	36-39
19845385-3	2009	Herein, we calculated the pK(a) values of these melamine derivatives in water, using a density functional theory quantum mechanical method [B3LYP/6-311++G(d,p)] in combination with the Poisson-Boltzmann continuum solvation model.	Water	72-77	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	142-145
19938104-1	2009	OBJECTIVE: The serum of most neuromyelitis optica (NMO) patients contains autoantibodies (NMO-IgGs) directed against the aquaporin-4 (AQP4) water channel located on astrocyte foot processes in the perivessel and subpial areas of the brain.	Water	140-145	aquaporin 4	Homo sapiens	121-132
19938104-1	2009	OBJECTIVE: The serum of most neuromyelitis optica (NMO) patients contains autoantibodies (NMO-IgGs) directed against the aquaporin-4 (AQP4) water channel located on astrocyte foot processes in the perivessel and subpial areas of the brain.	Water	140-145	aquaporin 4	Homo sapiens	134-138
19475327-0	2009	Episodic trihalomethane species and levels in tap water at a start of operation of advanced treatment in Osaka Prefectural water supplies.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
19475327-0	2009	Episodic trihalomethane species and levels in tap water at a start of operation of advanced treatment in Osaka Prefectural water supplies.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	46-49
19475327-1	2009	Dramatic changes in trihalomethanes of tap water caused by decreasing the chlorine dose from to break-point to zero at a pre-chlorination could be found during several years from starting the advanced treatment in Osaka Prefectural water utilities (from 1998 to 2002).	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
19874043-3	2009	In the present study, two new water-soluble polysaccharides, named LSP1 and LSP2, were isolated from the active crude polysaccharides by DEAE-cellulose 52 and AB-8 macroporous resin chromatography and tested for their hypoglycemic effects.	Water	30-35	lymphocyte specific 1	Mus musculus	67-71
19457619-2	2009	Some epidemiological studies suggest that even very low lithium levels induced by routine consumption of lithium from tap water may have anti-suicidal effects both in patients with mood disorders and in the general population.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
19457619-4	2009	If this is the case, increasing lithium levels of drinking water could potentially reduce the risk of suicide, and justify administering lithium to tap water.	Water	152-157	nuclear RNA export factor 1	Homo sapiens	148-151
19886947-5	2009	We then integrated the distribution of estimated leaching rates into an exposure model that estimated the probability distribution of OT concentrations in tap waters and the resulting potential human OT exposures via tap water consumption.	Water	159-164	nuclear RNA export factor 1	Homo sapiens	155-158
20352946-2	2009	Water-soluble cosmetic sample was extracted with water, and the extract was centrifuged, then the upper solution was cleaned up by an Oasis HLB solid phase extraction cartridge.	Water	0-5	cAMP responsive element binding protein 3 like 1	Homo sapiens	134-139
19515489-2	2009	The existence of two major elements viz., Cr6+ and Ni2+ in excess to permissible limit was observed in soil and water samples collected from the site.	Water	112-117	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	42-45
19695715-1	2009	NMO-IgG is a disease-specific autoantibody for neuromyelitis optica (NMO) that binds selectively to aquaporin-4 (AQ4), an astrocytic water channel.	Water	133-138	aquaporin 4	Homo sapiens	100-111
19695715-1	2009	NMO-IgG is a disease-specific autoantibody for neuromyelitis optica (NMO) that binds selectively to aquaporin-4 (AQ4), an astrocytic water channel.	Water	133-138	aquaporin 4	Homo sapiens	113-116
19615455-8	2009	DAW water extract, saponins fraction and akebia saponin D had the neuroprotective capacity to antagonize A beta(25-35)-induced cytotoxicity in PC 12 cells.	Water	4-9	amyloid beta precursor protein	Rattus norvegicus	105-111
19625070-0	2009	Surveying the mutagenicity of tap water to elicit the effects of purification processes on Japanese tap water.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
19625070-2	2009	Tap water samples (179) were collected at 17 sampling sites located from the northern tip (Hokkaido) to the southern tip (Kagoshima Prefecture).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
19625070-7	2009	The highest positive ratios of the Ames test and the umu test were 92% under the condition TA100-S9 and 9% under the condition NM2009-S9, respectively, which indicated that the Ames test has higher sensitivity for the test of tap water than the umu test.	Water	230-235	nuclear RNA export factor 1	Homo sapiens	226-229
19775722-2	2009	In the present study, therefore, environmental or tap water samples collected from various regions of China were assayed for PFOS and PFOA by solid phase extraction and liquid chromatography-mass spectrometry technique.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
19775722-8	2009	Many cities provided tap water with low levels of PFOS and PFOA, however, tap water in Guangzhou and Shenzhen exceeded 10ngL(-1) for both chemicals.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
19775722-8	2009	Many cities provided tap water with low levels of PFOS and PFOA, however, tap water in Guangzhou and Shenzhen exceeded 10ngL(-1) for both chemicals.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
19667009-1	2009	BACKGROUND: Antibodies against aquaporin-4 (AQP4), a water channel particularly expressed on perivascular astrocytic podocytes, are proposed as a marker for the diagnosis of neuromyelitis optica (NMO).	Water	53-58	aquaporin 4	Homo sapiens	31-42
19667009-1	2009	BACKGROUND: Antibodies against aquaporin-4 (AQP4), a water channel particularly expressed on perivascular astrocytic podocytes, are proposed as a marker for the diagnosis of neuromyelitis optica (NMO).	Water	53-58	aquaporin 4	Homo sapiens	44-48
19708669-6	2009	In methanol, the CD spectrum of somatostatin-14 keeps globally the same spectral shape as that observed in water, whereas its open analogue presents a major population of helical conformers.	Water	107-112	somatostatin	Homo sapiens	32-47
19464331-6	2009	Structure activity relationships across a wide range of sugars suggested Delta CPT was related to molar hydroxyl number, the orientation of the C(4) hydroxyl and the beta 1--&gt;4 linkage, all factors which influence sugar compatibility with water structure.	Water	242-247	choline phosphotransferase 1	Homo sapiens	79-82
19615509-8	2009	The procedure was applied to tap water, well water, and sea water; and accuracy was assessed through recovery experiment and independent analysis by graphite atomic absorption spectrometry.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
20448974-0	2009	Boiling water-catalyzed neutral and selective N-Boc deprotection.	Water	8-13	BOC cell adhesion associated, oncogene regulated	Homo sapiens	48-51
20448974-1	2009	A general protocol for removing Boc groups from various types of nitrogen is reported and a preliminary investigation of the reaction mechanism indicates that water acts as a dual acid/base catalyst at elevated temperature.	Water	159-164	BOC cell adhesion associated, oncogene regulated	Homo sapiens	32-35
19486431-2	2009	METHODS AND RESULTS: Published degenerate PCR primers were used to determine that 54% of tap water samples (7/13) were positive for a deh gene, indicating that drinking water distribution systems may harbour bacteria capable of HAA degradation.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
19486431-2	2009	METHODS AND RESULTS: Published degenerate PCR primers were used to determine that 54% of tap water samples (7/13) were positive for a deh gene, indicating that drinking water distribution systems may harbour bacteria capable of HAA degradation.	Water	169-174	nuclear RNA export factor 1	Homo sapiens	89-92
18830235-1	2009	Disinfection by-products in tap water have been found in some studies to be associated with adverse pregnancy outcomes, but little is known about how water use and consumption might change during early pregnancy.	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
18830235-5	2009	Changes were detected between early and mid-pregnancy for ingested cold tap water and showering.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
18830235-7	2009	Increases in cold tap water intake were associated with age &gt;35 years, income &lt; $40,000, and non-Hispanic white ethnicity.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
18830235-8	2009	We also found that the proportion of the total variation due to within-subject variability was 62% for hot tap water ingestion but only 35% for showering and approximately 50% for cold tap water, bottled water and bathing.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
18830235-8	2009	We also found that the proportion of the total variation due to within-subject variability was 62% for hot tap water ingestion but only 35% for showering and approximately 50% for cold tap water, bottled water and bathing.	Water	189-194	nuclear RNA export factor 1	Homo sapiens	185-188
19523167-12	2009	These findings suggest that central adiponectin plays an inhibitory role in the osmoregulation and baroregulation of AVP release, that the AMPK pathway is at least partly involved in the action of adiponectin, and further suggest a novel physiological or pathophysiological role for central adiponectin in water balance via inhibition of AVP release.	Water	306-311	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	36-47
19523167-12	2009	These findings suggest that central adiponectin plays an inhibitory role in the osmoregulation and baroregulation of AVP release, that the AMPK pathway is at least partly involved in the action of adiponectin, and further suggest a novel physiological or pathophysiological role for central adiponectin in water balance via inhibition of AVP release.	Water	306-311	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	197-208
19523167-12	2009	These findings suggest that central adiponectin plays an inhibitory role in the osmoregulation and baroregulation of AVP release, that the AMPK pathway is at least partly involved in the action of adiponectin, and further suggest a novel physiological or pathophysiological role for central adiponectin in water balance via inhibition of AVP release.	Water	306-311	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	197-208
19484338-0	2009	c-Fos expression in the supraoptic nucleus is the most intense during different durations of restraint water-immersion stress in the rat.	Water	103-108	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
19515809-11	2009	Snapin plays an important role as a linker between the water channel and the t-SNARE complex, leading to the fusion event, and the pairing with specific t-SNAREs is essential for the specificity of membrane recognition and fusion.	Water	55-60	SNAP associated protein	Canis lupus familiaris	0-6
19499332-7	2009	And these metabolites are responsible for separation of the data along PC1 and PC2 which may be used as biomarkers to indicate the source water pollution.	Water	138-143	minisatellite 6 hypermutable	Mus musculus	71-74
19545155-11	2009	This suggests that, in the docking process, biotin replaces six of the seven water molecules attached to the unliganded streptavidin binding site, and one remaining water molecule is squeezed into the gap between the Btn, Tyr43, Ser45, Trp92, and Trp79 residues in the binding pocket.	Water	165-170	butyrophilin subfamily 1 member A1	Homo sapiens	217-220
19451651-2	2009	A growing body of evidence points to a role for dystroglycan and its interaction with perivascular laminin in the targeting of the dystrophin complex and the water-permeable channel, aquaporin 4 (AQP4), at astrocyte endfeet.	Water	158-163	aquaporin 4	Homo sapiens	196-200
19708347-5	2009	At one STP in this area, an extremely high concentration of NDMA (10,000ng/L) was found in one influent water sample after ozonation.	Water	104-109	thyroid hormone receptor interactor 10	Homo sapiens	7-10
19774995-0	2009	[Membrane fouling alleviation characteristics of sludge/water pre-separation MBR].	Water	56-61	translocator protein	Homo sapiens	77-80
19774995-1	2009	A long-term operation was conducted to investigate the alleviation of membrane fouling by sludge/water pre-separation membrane bioreactor (S/W-MBR).	Water	97-102	translocator protein	Homo sapiens	143-146
19362131-6	2009	The numbers of albumin- and GFAP-positive cells strongly correlate with brain temperature, gradually increasing from approximately 38.5 degrees C and plateauing at 41-42 degrees C. Brains maintained at hyperthermia also showed larger content of brain water and Na(+), K(+) and Cl(-) as well as structural abnormalities of brain cells, all suggesting acute brain edema.	Water	251-256	glial fibrillary acidic protein	Rattus norvegicus	28-32
19757655-0	2009	[Editorial comment on the analysis of bottled and tap water in Spain and the impact of its consumption on urinary lithiasis].	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
19757664-0	2009	[Spanish bottled and tap water analysis and their relation with urinary lithiasis].	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
19757664-4	2009	RESULTS: Information about composition from tap water of most of the main Spanish cities and 85 bottled water brands was found.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
19285950-6	2009	Knockdown of PsbP modified both the donor and acceptor sides of PSII; In addition to the lower water-splitting activity, the primary quinone Q(A) in PSII was significantly reduced even when the photosystem I reaction center (P700) was noticeably oxidized, and thermoluminescence studies suggested the stabilization of the charged pair, S(2)/Q(A)(-).	Water	95-100	oxygen-evolving enhancer protein 2-2, chloroplastic	Nicotiana tabacum	13-17
19482477-4	2009	The water-soluble polymer-drug conjugate was designed to release a triple payload of the hydrophobic drug paclitaxel as a result of cleavage by the endogenous enzyme cathepsin B.	Water	4-9	cathepsin B	Mus musculus	166-177
19548636-3	2009	We used the Orru three component reaction (O-3CR) along with a rapid and efficient, recently discovered amidation reaction to dramatically improve the water solubility of our recently discovered low molecular weight p53/mdm2 antagonists.	Water	151-156	MDM2 proto-oncogene	Homo sapiens	220-224
19722439-7	2009	Reasons for giving children bottled water included: fear of contaminants in tap water; taste and/or smell of tap water; and convenience of bottled water.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	109-112
19406128-0	2009	Mechanism of aquaporin-4"s fast and highly selective water conduction and proton exclusion.	Water	53-58	aquaporin 4	Homo sapiens	13-24
19406128-6	2009	Our structure of AQP4, the predominant water channel in the brain, reveals eight water molecules in the channel.	Water	39-44	aquaporin 4	Homo sapiens	17-21
19406128-6	2009	Our structure of AQP4, the predominant water channel in the brain, reveals eight water molecules in the channel.	Water	81-86	aquaporin 4	Homo sapiens	17-21
19587904-1	2009	The integration of a selective Hg2+ receptor unit, 1,4-dioxa-7,13-dithia-10-azacyclopentadecane, into the 9-aminoacridizinium fluorophore provides a fluorescent probe which allows a selective ratiometric detection of Hg2+ in water.	Water	225-230	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	31-34
19378975-6	2009	Both simulations indicate the presence of one or two internal water molecules absent in both crystal structures and essential for the stabilization of the binding pocket at the interface between transmembrane helices III, IV, and V. The different interactions arising from the substitution of Tyr308 in beta(2)AR into Phe325 in beta(1)AR induce different conformations of the homologous Asn(6.55) inside the binding pockets of the two receptors, suggesting a possible origin of receptor specificity in agonist binding.	Water	62-67	adrenoceptor beta 2	Homo sapiens	303-312
20120163-8	2009	Good sanitation and safe tap water are major contributors to human health and well-being Major efforts and investments are needed, based on rigorous, objective assessments of risks for the environment and public health.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
19240354-3	2009	In addition, we investigated the daily volume of cold tap water consumed by those respondents who consumed no bottled water and the factors that influence this consumption.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
19240354-5	2009	The mean volume of water consumed in a day (including bottled and tap water) was 1.39 l. Among those who reported to exclusively consume tap water, the mean daily volume of tap water consumed was 1.45 l. The daily amount of cold water consumed in a day was lower for older respondents, more markedly for men than women.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	137-140
19240354-5	2009	The mean volume of water consumed in a day (including bottled and tap water) was 1.39 l. Among those who reported to exclusively consume tap water, the mean daily volume of tap water consumed was 1.45 l. The daily amount of cold water consumed in a day was lower for older respondents, more markedly for men than women.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	137-140
19240355-5	2009	Among 253 respondents who consumed water: (a) 177/253 (70%) of tap water samples contained more than 10 microg l(-1) total inorganic arsenic (ave. 66 microg l(-1), median 20 microg l(-1)); (b) As((III)) occurred as a small proportion of total arsenic in most samples (ave. 22%, median 3%); and (c) tungsten occurred in concentrations ranging from below the detection limit (3 microg l(-1)) to a maximum of 610 microg l(-1) (ave. 30 microg l(-1), median 3 microg l(-1)).	Water	35-40	nuclear RNA export factor 1	Homo sapiens	63-66
19240355-5	2009	Among 253 respondents who consumed water: (a) 177/253 (70%) of tap water samples contained more than 10 microg l(-1) total inorganic arsenic (ave. 66 microg l(-1), median 20 microg l(-1)); (b) As((III)) occurred as a small proportion of total arsenic in most samples (ave. 22%, median 3%); and (c) tungsten occurred in concentrations ranging from below the detection limit (3 microg l(-1)) to a maximum of 610 microg l(-1) (ave. 30 microg l(-1), median 3 microg l(-1)).	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
19240355-8	2009	This suggests that householders in this area were likely to be exposed to both metals simultaneously, given that 253/307 of the respondents (82%) reported consuming tap water.	Water	169-174	nuclear RNA export factor 1	Homo sapiens	165-168
19240358-7	2009	For tap water, the type of storage had a significant effect on the susceptibility to contamination (chi(2) = 12.090; p = 0.007).	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
19240359-1	2009	We examined whether the average water residence time, the time it takes water to travel from the treatment plant to the user, for a zip code was related to the proportion of emergency department (ED) visits for gastrointestinal (GI) illness among residents of that zip code.	Water	72-77	death associated protein kinase 3	Homo sapiens	132-135
19427509-9	2009	NAC administration via drinking water fully protected against DNA strand breaks in mice whole-body irradiated with 1Gy but not with 4Gy.	Water	32-37	X-linked Kx blood group	Homo sapiens	0-3
19428702-1	2009	We investigated the role of aquaporin-4 (AQP4), a water channel expressed in glial cells, in neural activity mediated morphological changes observed in brain slice preparation.	Water	50-55	aquaporin 4	Mus musculus	28-39
19428702-1	2009	We investigated the role of aquaporin-4 (AQP4), a water channel expressed in glial cells, in neural activity mediated morphological changes observed in brain slice preparation.	Water	50-55	aquaporin 4	Mus musculus	41-45
19324070-6	2009	Compared to the sham-operated rats, Abeta(25-35) injection significantly prolonged the mean escape latency in vehicle-treated rats in the Morris water maze test (p < 0.01) and increased both AD-related neuropathological signs (i.e., Abeta, amyloid precursor protein, and phosphorylated Tau immunoreactivity) and pro-inflammatory mediators (i.e., TNF-alpha and activated NF-kappaB) in the prefrontal cortex and CA1 subregion of the hippocampus.	Water	145-150	amyloid beta precursor protein	Rattus norvegicus	36-41
19374427-2	2009	In a methanol-water-0.006% acetic acid (v/v) gradient, envelopes with up to 11 SRI were apparent in both the +1 and +2 charge states with structures [M + Na(x) - (x-1)H](+) and [M + Na(x) - (x-2)H](+2).	Water	14-19	sorcin	Homo sapiens	79-82
19407386-3	2009	A joint X-ray and neutron crystallographic study has been initiated to determine the specific water network and the protonation states of the hydrophilic residues that coordinate it in human carbonic anhydrase II.	Water	94-99	carbonic anhydrase 2	Homo sapiens	191-212
19543414-0	2009	Fluoride intake through consumption of tap water and bottled water in Belgium.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
19543414-1	2009	There is a tendency to align higher levels of fluoride in natural mineral water with the existing higher levels in tap water.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
19543414-4	2009	A deterministic approach was used whereby consumption quantities of tap water and different brands of bottled water were linked with their respective fluoride concentrations.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
19151394-3	2009	Immunofluorescence histochemistry was performed to examine the localization of HMGB-1 and the receptor for advanced glycation end products (RAGEs) in eyes obtained from nontreated rats or EAU-induced rats.	Water	188-191	high mobility group box 1	Rattus norvegicus	79-85
19151394-5	2009	RESULTS: The level of HMGB-1 in aqueous humor was significantly elevated in eyes with EAU, and HMGB-1 and tumor necrosis factor (TNF)-alpha levels correlated with active ocular inflammation.	Water	86-89	high mobility group box 1	Rattus norvegicus	22-28
19151394-6	2009	HMGB-1 was expressed in the iris, ciliary body, and retina of eyes from nontreated rats and EAU-induced rats.	Water	92-95	high mobility group box 1	Rattus norvegicus	0-6
19151394-7	2009	Furthermore, HMGB-1 and RAGE were found in inflammatory cells infiltrating the anterior chamber, vitreous cavity, and subretinal space in EAU-induced rats.	Water	138-141	high mobility group box 1	Rattus norvegicus	13-19
19151394-10	2009	CONCLUSIONS: HMGB-1 was elevated in the aqueous humor of eyes with EAU.	Water	67-70	high mobility group box 1	Rattus norvegicus	13-19
19438126-10	2009	Industrial towns (Korangi, Landhi and SITE) had significantly higher concentration of chromium (micro = 82.4; SE = 8.9) in their ground and tap water as compared to the mean chromium concentration (micro = 33; SE = 2.2) in the water samples of rest of the towns of Karachi (P &lt; 0.001).	Water	144-149	nuclear RNA export factor 1	Homo sapiens	140-143
19303132-4	2009	The degradation could be described by a simple pseudo first-order rate law with rate constants of about 1.2 x 10(-3) m(2)J(-1) for geosmin and 2-MIB in ultrapure water.	Water	162-167	MIB E3 ubiquitin protein ligase 1	Homo sapiens	145-148
19303132-5	2009	In natural water used for drinking water abstraction the rate constants decreased to 2.7 x 10(-4) m(2)J(-1) for geosmin and 2.5 x 10(-4) m(2)J(-1) for 2-MIB due to the presence of NOM.	Water	11-16	MIB E3 ubiquitin protein ligase 1	Homo sapiens	153-156
19303132-5	2009	In natural water used for drinking water abstraction the rate constants decreased to 2.7 x 10(-4) m(2)J(-1) for geosmin and 2.5 x 10(-4) m(2)J(-1) for 2-MIB due to the presence of NOM.	Water	35-40	MIB E3 ubiquitin protein ligase 1	Homo sapiens	153-156
19368448-0	2009	Direct ab initio dynamics calculations for rates and the kinetic isotope effects of multiproton transfer in ClONO2 + HCl --&gt; HNO3 + Cl2 reactions with water clusters: breakdown of the rule of the geometric mean.	Water	154-159	endogenous retrovirus group W member 5	Homo sapiens	135-138
18941904-4	2009	These effects of H(2)O(2) were suppressed by pretreatment of the cells with 1 muM of LaCl(3) for 2 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2, JNK and p38 MAPK, but only the last two were associated with the ALP activity.	Water	17-22	PDZ and LIM domain 3	Rattus norvegicus	230-233
18941904-4	2009	These effects of H(2)O(2) were suppressed by pretreatment of the cells with 1 muM of LaCl(3) for 2 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2, JNK and p38 MAPK, but only the last two were associated with the ALP activity.	Water	115-120	PDZ and LIM domain 3	Rattus norvegicus	230-233
19136528-7	2009	In animals pre-treated with water, infusion of ISO induced an increase in heart-to-body weight ratio (HW/BW) by approximately 20%, an increase in ANP mRNA by approximately 350%, and a reduction in the inotropic effect of isoprenaline in left atrium by approximately 50%.	Water	28-33	natriuretic peptide A	Rattus norvegicus	146-149
19373578-10	2009	IL-17 rather than IFN-gamma plays a crucial role in the development of EAU, and that antagonism of IL-17 could be useful for the treatment of human intraocular autoimmune diseases.	Water	71-74	interleukin 17A	Homo sapiens	0-5
19669660-4	2009	The discovery of aquaporin-4, a subtype of water channel abundantly expressed in glial systems, further highlighted the concept that the dynamics of water molecules in the cerebral cortex play an important role in important physiological brain functions including consciousness and information processing.	Water	43-48	aquaporin 4	Homo sapiens	17-28
18365760-0	2009	Risk assessment of trihalomethanes from tap water in Fortaleza, Brazil.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
18365760-2	2009	The mean levels of THM compounds were obtained in Fortaleza tap water as follow: 63.9 microg L(-1) for chloroform (CHCl(3)), 40.0 microg L(-1) for bromodichloromethane (CHBrCl(2)), and 15.6 microg L(-1) for dibromochloromethane (CHBr(2)Cl).	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
18365760-4	2009	The mean CR for THMs in tap water is 3.96 x 10(-4).	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
19452923-4	2009	The dietary absorption efficiency decreased with increasing octanol-water partition coefficient of the BDE congener.	Water	68-73	homeobox D13	Homo sapiens	103-106
19114109-0	2009	Acetazolamide reversibly inhibits water conduction by aquaporin-4.	Water	34-39	aquaporin 4	Homo sapiens	54-65
19114109-3	2009	Here, we report the effect of inhibitors on water conduction by AQP4 and AQP1 reconstituted into liposomes.	Water	44-49	aquaporin 4	Homo sapiens	64-68
19114109-4	2009	Acetazolamide (AZA), an inhibitor of sulfonamide carbonic anhydrase (CA), reversibly inhibits water permeation through AQP4, but not through AQP1.	Water	94-99	aquaporin 4	Homo sapiens	119-123
19114109-6	2009	Our results thus demonstrate that AZA acts as a reversible inhibitor for AQP4-mediated water conduction and indicate that AZA is specific, at least to some degree, for AQP4.	Water	87-92	aquaporin 4	Homo sapiens	73-77
18923397-1	2009	Aquaporin-4 (AQP4), a key molecule for maintaining water homeostasis in the central nervous system, is expressed in adult neural stem cells (ANSCs) as well as astrocytes.	Water	51-56	aquaporin 4	Mus musculus	0-11
18923397-1	2009	Aquaporin-4 (AQP4), a key molecule for maintaining water homeostasis in the central nervous system, is expressed in adult neural stem cells (ANSCs) as well as astrocytes.	Water	51-56	aquaporin 4	Mus musculus	13-17
19356689-7	2009	CAA causes a loss of apparent glial fibrillary acidic protein (GFAP)-positive astrocytic end-feet and loss of water channels (aquaporin 4) localized to astrocytic end feet.	Water	110-115	nucleotriphosphatase	Mus musculus	0-3
19356689-7	2009	CAA causes a loss of apparent glial fibrillary acidic protein (GFAP)-positive astrocytic end-feet and loss of water channels (aquaporin 4) localized to astrocytic end feet.	Water	110-115	aquaporin 4	Mus musculus	126-137
19341604-2	2009	The company issued advice through mass media to boil tap water before consumption; this advice was lifted six days later.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
19368213-4	2009	Transition of chemical equilibrium of the BrO3- reductive reaction was theorized as the reason for pH dependency of the BrO3- reduction.The electrochemicaltreatment of BrO3- -contaminated tap water resulted in a rapid decrease in BrO3- concentration from 100 to 48 microg/L with a contact time of 9.2 s. Thus, electrochemical treatment allowed the rapid removal of BrO3-.	Water	192-197	nuclear RNA export factor 1	Homo sapiens	188-191
19178932-3	2009	The main hypothesis was that the difference in the alkalinity value between tap water and domestic wastewater is almost exclusively a result of the hydrolysis of urea (NH(2)CONH(2), excreted in the human urine) to ammonia (NH(3)), regardless of the question what fraction of NH(3(aq)) is transformed to NH(4)(+).	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
19178932-4	2009	Results from a field study show that the ratio between the alkalinity added to tap water when raw wastewater is formed (in meq/l units) and the TAN (total ammonia nitrogen, mole/l) concentration in the raw wastewater is almost 1:1 in purely domestic sewage and close to 1:1 in domestic wastewater streams mixed with light industry wastewaters.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
19262558-2	2009	GA3, a new GA derivative, has been shown to possess better water solubility than GA.	Water	59-64	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	0-3
19225614-1	2009	A one-step S(N)Ar(H) reaction has been used for the synthesis of photostable probe , which has good water solubility and low cytotoxicity; this probe can be used for targeted imaging of tumour cells by virtue of specific binding between integrin alpha(v)beta(3) and an arginine-glycine-aspartic acid tripeptide sequence.	Water	100-105	integrin subunit alpha V	Homo sapiens	237-261
19140664-3	2009	Herein, we describe the SAR of a new series of water-soluble 2,4,6-trisubstituted pyrimidines where R1 is an aromatic heterocycle, R2 is a short-chain alkyl amide, and the typical R3 aromatic heterocyclic substituent is replaced with an aliphatic amino substituent.	Water	47-52	sarcosine dehydrogenase	Homo sapiens	24-27
19192492-1	2009	Ab intitio molecular dynamics simulation of the electronic structure of the aqueous superoxide anion (O2(-)) has been carried out using the Car-Parrinello density functional theory at 298 and 310 K. The modeling system consists of one O2(-) solvated in 31 water molecules.	Water	256-261	immunoglobulin kappa variable 1D-39	Homo sapiens	102-107
19073186-6	2009	On the basis of present findings, it is concluded that water deprivation down regulates the mRNA expression of AVT receptor VT2 as well as POMC but stimulates adrenal function.	Water	55-60	proopiomelanocortin	Gallus gallus	139-143
19348653-5	2009	Overexpression of gpp throughout the adult stage did not extend the lifespan, but significantly enhanced resistances when they were kept on medium containing 1% H(2)O(2), or those with poor nutrients.	Water	161-166	grappa	Drosophila melanogaster	18-21
18818882-6	2009	In this work, we propose a parameterization of an empirical model for n-octanol/water, alkane/water (logP(alk)) and cyclohexane/water (logP(cyc)) systems.	Water	94-99	ALK receptor tyrosine kinase	Homo sapiens	87-90
18818882-6	2009	In this work, we propose a parameterization of an empirical model for n-octanol/water, alkane/water (logP(alk)) and cyclohexane/water (logP(cyc)) systems.	Water	94-99	ALK receptor tyrosine kinase	Homo sapiens	87-90
19212590-0	2009	A bright water-compatible sugar-rhodamine fluorescence sensor for selective detection of Hg2+ in natural water and living cells.	Water	9-14	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	89-92
19212590-0	2009	A bright water-compatible sugar-rhodamine fluorescence sensor for selective detection of Hg2+ in natural water and living cells.	Water	105-110	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	89-92
19123823-4	2009	But, the anti-syn interconversion occurs relatively faster in water solvent than in chloroform solvent.	Water	62-67	synemin	Homo sapiens	14-17
19123823-7	2009	On the basis of the CPMD calculations, the syn form of adenosine in water has a larger dipole moment than the anti form.	Water	68-73	synemin	Homo sapiens	43-46
19115843-5	2009	In the X-ray crystal structures of the CA II-chlorthalidone adduct three active site water molecules interacting with the inhibitor scaffold were observed that lack in the corresponding indapamide adduct.	Water	85-90	carbonic anhydrase 2	Homo sapiens	39-44
18178093-1	2009	The potential of antiepileptic drugs (AEDs) to inhibit the water transport properties of aquaporin 4 (AQP4) was investigated using a combination of in silico and in vitro screening methods.	Water	59-64	aquaporin 4 L homeolog	Xenopus laevis	89-100
18178093-1	2009	The potential of antiepileptic drugs (AEDs) to inhibit the water transport properties of aquaporin 4 (AQP4) was investigated using a combination of in silico and in vitro screening methods.	Water	59-64	aquaporin 4 L homeolog	Xenopus laevis	102-106
19011027-6	2009	Moreover, the advantage of catalase production by S. aureus in competition with a non-catalase-producing strain (KatA) during nasal colonization was no greater in the presence of H(2)O(2)-producing S. pneumoniae than in the presence of non-H(2)O(2)-producing S. pneumoniae.	Water	179-184	AT695_RS10915	Staphylococcus aureus	27-35
19288451-6	2009	The developed sensor was applied to tap water and the urine of a smoker.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
20131599-1	2009	Chemotaxis to water-soluble attractants is mainly controlled by ASE sensory neuron whose specification is regulated by che-1 in Caenorhabditis elegans.	Water	14-19	Transcription factor che-1	Caenorhabditis elegans	119-124
20131599-5	2009	Furthermore, we observed significant decreases of chemotaxis to water-soluble attractants in Pb exposed che-1 mutant at concentrations more than 2.5 micromol/L, and in Cu, Ag, and Cr exposed che-1 mutant at concentrations more than 50 micromol/L.	Water	64-69	Transcription factor che-1	Caenorhabditis elegans	104-109
19584117-11	2009	Consistent with the view that RACK1 negatively regulates ABA responses, rack1a mutants lose water significantly more slowly from the rosettes and are hypersensitive to high concentrations of NaCl during seed germination.	Water	92-97	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	72-78
19055388-0	2008	Spin-labeled stearic acid behavior and perturbations on the structure of a gel-phase-lipid bilayer in water: 5-, 12- and 16-SASL.	Water	102-107	spindlin 1	Homo sapiens	0-4
27873995-5	2008	The trajectory and the interaction energy clearly indicate that the adsorption of GOx onto SWCNTs plays an important role in the conformational mobility of the coenzyme, and its mobility is greatly affected by the distribution of water molecules due to it being hydrophobic.	Water	230-235	hydroxyacid oxidase 1	Homo sapiens	82-85
18805568-5	2008	In tap water, at the groundwater supplied sampling point, brominated species, bromoform and dibromoacetonitrile, were detected at the highest levels most probably due to bromide ion intrusion from seawater.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
19030623-5	2008	Observed first-order rate constants in the presence of 1-2 mM Mg(II) or Ca(II) in neutral and weakly basic solutions were 10(8)-10(11) times higher than those for background hydrolysis at the same pH while in water additions of up to 50 mM metal produced &lt;100-fold accelerations.	Water	209-214	carbonic anhydrase 2	Homo sapiens	72-78
18831960-2	2008	After incubation of OPP liposomes with MT-3 cells, a reduction of liposome entrapped, water soluble spin-probe tempocholine (ASL) was observed, indicating that ASL is released from liposomes and is reduced by oxy-redoxy systems inside the cells.	Water	86-91	argininosuccinate lyase	Homo sapiens	125-128
18831960-2	2008	After incubation of OPP liposomes with MT-3 cells, a reduction of liposome entrapped, water soluble spin-probe tempocholine (ASL) was observed, indicating that ASL is released from liposomes and is reduced by oxy-redoxy systems inside the cells.	Water	86-91	argininosuccinate lyase	Homo sapiens	160-163
18832438-10	2008	Together, these data indicate that the polyuria observed in VDR-null mice is not caused by impaired renal fluid handling or increased intestinal salt absorption but rather is the result of increased water intake induced by the increase in systemic and brain angiotensin II.	Water	199-204	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	60-63
18838247-2	2008	EAU is induced in B10.RIII mice by immunization with RBP-3 161-180 peptide and intraperitoneal pertussis toxin and is mediated by CD4(+) T cells that generate a clinically monophasic disease peaking approximately 2 weeks post-immunization.	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	53-58
18838247-2	2008	EAU is induced in B10.RIII mice by immunization with RBP-3 161-180 peptide and intraperitoneal pertussis toxin and is mediated by CD4(+) T cells that generate a clinically monophasic disease peaking approximately 2 weeks post-immunization.	Water	0-3	CD4 antigen	Mus musculus	130-133
19107388-4	2008	Here we analyzed thirty-two hospital tap water samples that were collected from different locations in three hospitals so as to evaluate the prevalence of NTM species.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
19037500-1	2008	Coumarin derivatives with non-polar substituents at the 6 or 7 position undergoes photodimerization in the presence of CB[8] in water to give the syn dimer as the major product.	Water	128-133	synemin	Homo sapiens	146-149
19087789-11	2008	In tap water Ca2+ concentrations ranged between 0-337 mg/l, Na+ between 1-332 mg/l, and Mg(2+) between 0.3-315 mg/l.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
19087789-13	2008	CONCLUSIONS: Water, even bottled water or tap water, has a great variability in the concentrations of Ca(2+), Mg(2+) and Na(+).	Water	13-18	nuclear RNA export factor 1	Homo sapiens	42-45
19087789-13	2008	CONCLUSIONS: Water, even bottled water or tap water, has a great variability in the concentrations of Ca(2+), Mg(2+) and Na(+).	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
18988737-6	2008	These results demonstrate that mouse TRPA1 channels expressed in sensory neurons cause an aversion to drinking caffeine-containing water, suggesting they mediate the perception of caffeine.	Water	131-136	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	37-42
18847252-7	2008	Over the course of 11 ns MD simulations, the open channel remained open with filled water, but the closed channel showed a much lower water density at its hydrophobic gate comprised of residues alpha4-V259 and alpha4-L263 and their homologous residues in the beta2 subunits.	Water	134-139	immunoglobulin binding protein 1	Homo sapiens	194-200
18784337-8	2008	The distension increased the number of Fos- and double-labeled Fos/CRF neurons in the parvocellular PVN, which was higher in the water-deprived than in the hydrated group (P &lt; 0.01).	Water	129-134	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-42
18784337-8	2008	The distension increased the number of Fos- and double-labeled Fos/CRF neurons in the parvocellular PVN, which was higher in the water-deprived than in the hydrated group (P &lt; 0.01).	Water	129-134	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-66
18945724-3	2008	Subsequently, aquaporin-4 (AQP4), the most abundant water channel in the CNS, was identified as its target antigen.	Water	52-57	aquaporin 4	Homo sapiens	14-25
18945724-3	2008	Subsequently, aquaporin-4 (AQP4), the most abundant water channel in the CNS, was identified as its target antigen.	Water	52-57	aquaporin 4	Homo sapiens	27-31
19232219-8	2008	DISCUSSION: Since the results obtained in the analyses of the substances used were correct and no adverse effect was observed after the re-administration of the substances, we may conclude that the outbreak would be related to the washing process performed previously to the sterilization of the instrumentation used in the surgery, mainly because the recommendation to use distilled and sterile water for this purpose was not followed and, on the contrary, tap water continued to be used.	Water	396-401	nuclear RNA export factor 1	Homo sapiens	458-461
19232219-8	2008	DISCUSSION: Since the results obtained in the analyses of the substances used were correct and no adverse effect was observed after the re-administration of the substances, we may conclude that the outbreak would be related to the washing process performed previously to the sterilization of the instrumentation used in the surgery, mainly because the recommendation to use distilled and sterile water for this purpose was not followed and, on the contrary, tap water continued to be used.	Water	462-467	nuclear RNA export factor 1	Homo sapiens	458-461
19271520-0	2008	[A flow injection on-line unequal flow complexation preconcentration procedure coupled with flame atomic absorption spectrometry for determination of lead in tap water].	Water	162-167	nuclear RNA export factor 1	Homo sapiens	158-161
19271520-1	2008	A simple, environmentally friendly, cost-effective, and sensitive method was developed for the determination of trace lead in tap water by flow injection (FI) on-line unequal flow complexation preconcentration procedure coupled with flame atomic absorption spectrometry (FAAS).	Water	130-135	nuclear RNA export factor 1	Homo sapiens	126-129
19271520-11	2008	The proposed method has been successfully applied to the determination of lead in tap water samples.	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
18779436-5	2008	Unilateral injection of Ang II (0.6, 6, and 60 pmol) into the RVLM produced a significantly greater increase in renal SNA and mean ABP of rats drinking 0.9% NaCl versus water.	Water	169-174	angiogenin	Rattus norvegicus	24-27
18755475-3	2008	For the copolymer, the limiting area per segment versus temperature shows a break point around 29 degrees C, slightly lower than the lower critical solution temperature (LCST) of h-PDEA in water (31-33 degrees C).	Water	189-194	phosphodiesterase 6A	Homo sapiens	181-185
19198125-2	2008	Aquaporin-4 (AQP4) is a predominantly expressed water channel in the mammalian brain and an important drug target for treatment of cerebral edema, bipolar disorder, and mesial temporal lobe epilepsy.	Water	48-53	aquaporin 4	Homo sapiens	0-11
19198125-2	2008	Aquaporin-4 (AQP4) is a predominantly expressed water channel in the mammalian brain and an important drug target for treatment of cerebral edema, bipolar disorder, and mesial temporal lobe epilepsy.	Water	48-53	aquaporin 4	Homo sapiens	13-17
19198125-8	2008	These findings suggest that there must be the complicated mechanism for control of water content relevant to AQP4 within the brain.	Water	83-88	aquaporin 4	Homo sapiens	109-113
19003750-3	2008	A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
18328622-6	2008	NH(4)(+) was identified as a reduction product for RDX and NG in the pyrite-water system.	Water	76-81	radixin	Homo sapiens	51-54
18678877-7	2008	The NMDGT motif on the partially unwound part of the transmembrane helix TM7 and the residues Asp-390 and Asp-394 on TM8 are also distinguished by their important role in substrate binding and close interaction with mediating water molecules and/or sodium ions.	Water	226-231	tetraspanin 16	Homo sapiens	117-120
18953970-7	2008	Studies have shown that tap water is safe to use for irrigation, that white petrolatum ointment is as effective as antibiotic ointment in postprocedure care, and that wetting the wound as early as 12 hours after repair does not increase the risk of infection.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
18853706-9	2008	However, when the patient was restudied with his VNS device turned off, a nasal CPAP pressure of 13 cm H2O resulted in effective treatment of his severe OSAHS.	Water	103-106	centromere protein J	Homo sapiens	80-84
18842119-0	2008	Impact of a silver layer on the membrane of tap water filters on the microbiological quality of filtered water.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
18842119-0	2008	Impact of a silver layer on the membrane of tap water filters on the microbiological quality of filtered water.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	44-47
18793182-1	2008	The AOX (alternative oxidase) is a non-protonmotive ubiquinol-oxygen oxidoreductase that couples the oxidation of ubiquinol with the complete reduction of water.	Water	155-160	acyl-CoA oxidase 1	Homo sapiens	4-7
18793182-1	2008	The AOX (alternative oxidase) is a non-protonmotive ubiquinol-oxygen oxidoreductase that couples the oxidation of ubiquinol with the complete reduction of water.	Water	155-160	acyl-CoA oxidase 1	Homo sapiens	9-28
18793182-1	2008	The AOX (alternative oxidase) is a non-protonmotive ubiquinol-oxygen oxidoreductase that couples the oxidation of ubiquinol with the complete reduction of water.	Water	155-160	thioredoxin reductase 1	Homo sapiens	69-83
18621138-8	2008	Taken together, these results indicated that the presence of AQPs in chick kidney is similar to that in mammals, that the chick kidney has an additional AQP9 and that AQP1, 2, 3 and 9 may play a crucial but different role in water permeability in this organ.	Water	225-230	aquaporin 1	Gallus gallus	167-183
18155958-10	2008	Mean MetHb was normal when the nitrate concentration in water was below 50mg/l as NO3-, and reached an abnormal level, when the nitrate concentration in water ranged between 50 and 90mg/l as NO3-.	Water	56-61	hemoglobin subunit gamma 2	Homo sapiens	5-10
18802082-7	2008	Surprisingly, superior protection against EAU was achieved with alpha-C-GalCer, which induces a strong IFN-gamma but only a weak IL-4 production by iNKT cells, in contrast to the ligands alpha-GalCer (both IFN-gamma and IL-4) and OCH (primarily IL-4).	Water	42-45	ochre	Mus musculus	230-233
18800868-5	2008	The WDT was performed, consisting of a baseline intraocular pressure (IOP) measurement, followed by the ingestion of 1 L of tap water within 5 min.	Water	128-133	nuclear RNA export factor 1	Homo sapiens	124-127
18712869-2	2008	The back conversion from para-hydrogen ( p-H 2) to ortho-hydrogen ( o-H 2) was followed by NMR by recording the increase in the intensity of the signal of o-H 2 at regular intervals of time.	Water	155-160	polyhomeotic homolog 2	Homo sapiens	41-46
18700754-4	2008	The computed values of the exchange coupling between the Co(II) ions across anti-syn carboxylate (1) and syn-syn carboxylate/water (2) bridges are J = -0.060 (1) and -1.90 (2) cm(-1) (with the Hamiltonian being defined as H = -Jsigma(i,j)S(i) x S(j)).	Water	125-130	synemin	Homo sapiens	105-108
18700754-4	2008	The computed values of the exchange coupling between the Co(II) ions across anti-syn carboxylate (1) and syn-syn carboxylate/water (2) bridges are J = -0.060 (1) and -1.90 (2) cm(-1) (with the Hamiltonian being defined as H = -Jsigma(i,j)S(i) x S(j)).	Water	125-130	synemin	Homo sapiens	105-108
18700754-5	2008	These values follow the different conformations of the carboxylate bridge in 1 (anti-syn) and 2 (syn-syn) with the occurrence of a double bridge in 2 (water/carboxylate).	Water	151-156	synemin	Homo sapiens	85-88
18700754-5	2008	These values follow the different conformations of the carboxylate bridge in 1 (anti-syn) and 2 (syn-syn) with the occurrence of a double bridge in 2 (water/carboxylate).	Water	151-156	synemin	Homo sapiens	97-100
18700754-5	2008	These values follow the different conformations of the carboxylate bridge in 1 (anti-syn) and 2 (syn-syn) with the occurrence of a double bridge in 2 (water/carboxylate).	Water	151-156	synemin	Homo sapiens	97-100
18714985-4	2008	Moreover, based upon our thermochemical results for single water addition, primary hydration numbers of 6, 7, and 8 are all thermally accessible at STP.	Water	59-64	thyroid hormone receptor interactor 10	Homo sapiens	148-151
18702514-6	2008	Here we show that the HPLRP2 is directly inhibited by E600, does not present interfacial activation, and acts preferentially on substrates forming monomers or small aggregates (micelles) dispersed in solution like monoglycerides, phospholipids and galactolipids, whereas classical PL displays reverse properties and a high specificity for unsoluble substrates like triglycerides and diglycerides forming oil-in-water interfaces.	Water	411-416	pancreatic lipase	Homo sapiens	23-25
18683923-1	2008	Dry water stores 175 v(STP)/v methane at 2.7 MPa and 273.2 K in a hydrate form which is close to the Department of Energy volumetric target for methane storage.	Water	4-9	thyroid hormone receptor interactor 10	Homo sapiens	23-26
18690748-5	2008	However, the pig and chicken Sdh enzymes show an alternative entrance to the water channel via the conserved SdhD (Q78) residue.	Water	77-82	succinate dehydrogenase complex subunit D	Gallus gallus	109-113
18448591-8	2008	Initially, hyponatremia leads to an influx of water into the brain, primarily through glial cells and largely via the water channel aquaporin (AQP)4.	Water	46-51	aquaporin 4	Homo sapiens	143-148
18448591-8	2008	Initially, hyponatremia leads to an influx of water into the brain, primarily through glial cells and largely via the water channel aquaporin (AQP)4.	Water	118-123	aquaporin 4	Homo sapiens	143-148
18709190-10	2008	This method was successfully applied to the determination of arsenate in mineral-, drinking- and tap-water samples.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
18647319-1	2008	Aquaporin 5 (AQP5) is one of the water channel proteins which participate in a wide array of physiological processes and are primary determinants of membrane osmotic water permeability.	Water	33-38	aquaporin 5	Mus musculus	0-11
18647319-1	2008	Aquaporin 5 (AQP5) is one of the water channel proteins which participate in a wide array of physiological processes and are primary determinants of membrane osmotic water permeability.	Water	33-38	aquaporin 5	Mus musculus	13-17
18647319-1	2008	Aquaporin 5 (AQP5) is one of the water channel proteins which participate in a wide array of physiological processes and are primary determinants of membrane osmotic water permeability.	Water	166-171	aquaporin 5	Mus musculus	0-11
18647319-1	2008	Aquaporin 5 (AQP5) is one of the water channel proteins which participate in a wide array of physiological processes and are primary determinants of membrane osmotic water permeability.	Water	166-171	aquaporin 5	Mus musculus	13-17
18647319-9	2008	AQP5-mediated water transmembrane may play some role in the function of DCs.	Water	14-19	aquaporin 5	Mus musculus	0-4
18713580-3	2008	That fact that the biomarker is an autoantibody that recognizes aquaporin 4 (AQP4), a water channel expressed on astrocyte podocytes, has substantially contributed to the hypothesis that NMO is a humorally mediated autoimmune disease.	Water	86-91	aquaporin 4	Homo sapiens	64-75
18713580-3	2008	That fact that the biomarker is an autoantibody that recognizes aquaporin 4 (AQP4), a water channel expressed on astrocyte podocytes, has substantially contributed to the hypothesis that NMO is a humorally mediated autoimmune disease.	Water	86-91	aquaporin 4	Homo sapiens	77-81
19093556-10	2008	On the other hand, it was also observed that a remarkable change appeared in the O-H-O bending vibration of water and the stretching vibration of P=O in TBP molecules shifted to lower frequency.	Water	108-113	TATA-box binding protein	Homo sapiens	153-156
19093556-12	2008	The changes in delta 31P to opposite direction of delta H+ means that TBP molecules were associated with acid protons and water molecules in microemulsion pools to form RP=O x H+ or RP=O x H3O+, and then interacted with PdCl4(2-) complex ions, which finally led to the extraction of palladium into the organic phase.	Water	122-127	TATA-box binding protein	Homo sapiens	70-73
18571348-1	2008	The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort.	Water	256-261	IGF2 antisense RNA	Homo sapiens	179-184
18665139-2	2008	Oral sodium phosphate (NaP) is one of the most commonly used bowel preparations and is associated with considerable water and electrolyte shifts.	Water	116-121	catenin beta like 1	Homo sapiens	23-26
18431594-4	2008	Driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels.	Water	43-48	aquaporin 4	Homo sapiens	144-148
18431594-4	2008	Driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels.	Water	149-154	aquaporin 4	Homo sapiens	144-148
18682426-4	2008	The role of phosphorylation in the water channel activity of wild-type and mutant ZmPIP2;1 was studied in Xenopus laevis oocytes.	Water	35-40	aquaporin PIP2-1	Zea mays	82-90
18682426-5	2008	Activation of endogenous protein kinase A increased the osmotic water permeability coefficient of ZmPIP2;1-expressing oocytes, suggesting that phosphorylation activates its channel activity.	Water	64-69	aquaporin PIP2-1	Zea mays	98-106
18549808-3	2008	From the crystal structures with various ligands, the non-nucleoside type inhibitors bind to the active site occupying the critical water-binding-position and sustain the open form of apo-ADA.	Water	132-137	adenosine deaminase	Homo sapiens	188-191
18620920-7	2008	The procedure was applied to tap water, well water, river water and sea water, and accuracy was assessed through the analysis of certified reference water or recovery experiments.	Water	33-38	nuclear RNA export factor 1	Homo sapiens	29-32
18637679-0	2008	Highly sensitive multiresponsive chemosensor for selective detection of Hg2+ in natural water and different monitoring environments.	Water	88-93	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	72-75
18656684-5	2008	The proposed method was successfully applied to the analysis of tap water and well water samples.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
18692467-0	2008	Fluorescence mapping of mitochondrial TIM23 complex reveals a water-facing, substrate-interacting helix surface.	Water	62-67	translocase of inner mitochondrial membrane 23	Homo sapiens	38-43
18675148-2	2008	Tap water probing revealed persistent colonization of all ICU water taps with a single P aeruginosa clonotype.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
18675148-2	2008	Tap water probing revealed persistent colonization of all ICU water taps with a single P aeruginosa clonotype.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	0-3
18539760-4	2008	We found that BMP-4 (from 0.3 to 10 ng/ml) in CAECs increased O(2)(*-) and H(2)O(2) generation, induced NF-kappaB activation, upregulated ICAM-1, and induced monocyte adhesiveness to ECs.	Water	75-80	bone morphogenetic protein 4	Rattus norvegicus	14-19
18572411-0	2008	Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides.	Water	20-25	aquaporin 4	Homo sapiens	8-19
18617397-2	2008	The compounds exhibit excellent physiochemical properties and a novel binding mode, whereby a bridging interaction via a water molecule with Asp 86 of CDK2, leads to selectivity for the CDK family of enzymes over other kinases.	Water	121-126	cyclin-dependent kinase 2	Mus musculus	151-155
18495865-1	2008	Freeze-fracture electron microscopy (FFEM) indicates that aquaporin-4 (AQP4) water channels can assemble in cell plasma membranes in orthogonal arrays of particles (OAPs).	Water	77-82	aquaporin 4	Homo sapiens	58-69
18495865-1	2008	Freeze-fracture electron microscopy (FFEM) indicates that aquaporin-4 (AQP4) water channels can assemble in cell plasma membranes in orthogonal arrays of particles (OAPs).	Water	77-82	aquaporin 4	Homo sapiens	71-75
18769704-0	2008	A reader responds to "Should we use saline or tap water for cleansing wounds?	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
18554810-5	2008	This stimulation by CART peptide was also restored by treatment with the water-soluble form of E(2), but not by treatment with the membrane-impermeable form of E(2) in OVX female rats, suggesting that E(2) acts through intracellular rather than extracellular mechanisms to modulate the effects of CART peptide.	Water	73-78	CART prepropeptide	Rattus norvegicus	20-24
18641458-1	2008	Aquaporin-4 (AQP4) is the major water channel expressed in fast-twitch skeletal muscle fibers.	Water	32-37	aquaporin 4	Homo sapiens	0-11
18641458-1	2008	Aquaporin-4 (AQP4) is the major water channel expressed in fast-twitch skeletal muscle fibers.	Water	32-37	aquaporin 4	Homo sapiens	13-17
18509092-1	2008	BACKGROUND: In adult patients, autoantibodies targeting the water channel aquaporin-4 (AQP4) are a biomarker for a spectrum of CNS inflammatory demyelinating disorders with predilection for optic nerves and spinal cord (neuromyelitis optica [NMO]).	Water	60-65	aquaporin 4	Homo sapiens	87-91
18523430-7	2008	Oxalate stimulates the uptake of chloride, water, and sodium by the proximal tubule through the exchange of oxalate for sulfate or chloride via the solute carrier SLC26A6.	Water	43-48	solute carrier family 26 member 6	Homo sapiens	163-170
18761943-8	2008	Identical norovirus sequences were detected in stool samples, on surfaces and in tap water.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
18761943-11	2008	Epidemiological results indicated that consuming tap water was a risk factor; however, this could not be concluded definitively on the basis of the available data.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
18425739-7	2008	Pure trimeric Hpca (triphenylisomelamine) was obtained either by recrystallization of the mixed crystals from boiling water or by trimerization of monomeric Hpca in isopropanol for 12 h under reflux conditions.	Water	118-123	hippocalcin	Homo sapiens	14-18
18167118-3	2008	Indeed, the osmotic water permeability (P(f)) of AQP4 expressed in various types of cells, including Xenopus oocytes, is not inhibited by HgCl2.	Water	20-25	aquaporin 4 L homeolog	Xenopus laevis	49-53
18351631-8	2008	The uptake of water in astrocytes is likely to reflect the strong expression of aquaporin-4 in these cells.	Water	14-19	aquaporin 4	Mus musculus	80-91
18518807-11	2008	Thus, although exposure to disinfection by-products in tap water may be a risk factor for human bladder cancer, this may not be true for canine bladder cancer at the concentrations at which dogs are exposed.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
18538069-9	2008	However, filtering a tap-water solution of 0.8 mg F/L reduced the fluoride concentration only until 8 L had been filtered.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
18375385-1	2008	Aquaporin-4 (AQP4) is a water transport protein expressed in glial cell plasma membranes, including glial cell foot processes lining the blood-brain barrier.	Water	24-29	aquaporin 4	Mus musculus	0-11
18375385-1	2008	Aquaporin-4 (AQP4) is a water transport protein expressed in glial cell plasma membranes, including glial cell foot processes lining the blood-brain barrier.	Water	24-29	aquaporin 4	Mus musculus	13-17
18375385-5	2008	However, following acute water intoxication produced by intraperitoneal water injection, AQP4-overexpressing mice had an accelerated progression of cytotoxic brain swelling, with ICP elevation of 20 +/- 2 mmHg at 10 min, often producing brain herniation and death.	Water	25-30	aquaporin 4	Mus musculus	89-93
18375385-7	2008	The deduced increase in brain water content correlated linearly with brain AQP4 protein expression.	Water	30-35	aquaporin 4	Mus musculus	75-79
18375385-8	2008	We conclude that AQP4 expression is rate-limiting for brain water accumulation, and thus, that altered AQP4 expression can be functionally significant.	Water	60-65	aquaporin 4	Mus musculus	17-21
18234816-0	2008	Osmotic water transport with glucose in GLUT2 and SGLT.	Water	8-13	solute carrier family 2 member 2	Homo sapiens	40-45
18041758-11	2008	However, the GLIDE docking calculations both with (GLIDE XP) and without (GLIDE SP and XP) the cavity water molecules were, impressively, further able to accurately reproduce the finer details of the GPb-glucosyltriazolylacetamide complex structure.	Water	102-107	glycogen phosphorylase B	Homo sapiens	200-203
18076078-6	2008	This dramatic difference in affinity between the two compounds, which differ by only one hydroxyl group, is rationalized in terms of bound water molecules and the water molecule substructure in the active site, as identified by comparison of high resolution X-ray crystal structures of several dGMII-inhibitor complexes.	Water	139-144	alpha-Mannosidase class II a	Drosophila melanogaster	294-299
18076078-6	2008	This dramatic difference in affinity between the two compounds, which differ by only one hydroxyl group, is rationalized in terms of bound water molecules and the water molecule substructure in the active site, as identified by comparison of high resolution X-ray crystal structures of several dGMII-inhibitor complexes.	Water	163-168	alpha-Mannosidase class II a	Drosophila melanogaster	294-299
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Water	173-178	solute carrier family 12 member 1	Rattus norvegicus	84-89
18280225-3	2008	In the airways, AQP3 and AQP4 facilitate water transport.	Water	41-46	aquaporin 4	Homo sapiens	25-29
18358631-5	2008	Intragastric water administration increased the number of Fos-immunoreactive cells in the infralimbic cortex and lateral part of the central nucleus of the amygdala compared with the naive group.	Water	13-18	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-61
18358631-6	2008	Ethanol administration increased the number of Fos-immunoreactive cells in the infralimbic (+57.5%) and prelimbic (+105.3%) cortices, nucleus accumbens shell region (+88.2%), medial part of the central nucleus of the amygdala (+160%), and lateral part of the bed nucleus of the stria terminalis (+198.8%) compared with the water-treated group.	Water	323-328	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	47-50
18275838-2	2008	The 5"-phosphate of the PLP cofactor is very tightly bound to the enzyme; it accepts 8 hydrogen bonds from enzyme side chains and a pair of water molecules, and is in close proximity to a helix dipole.	Water	140-145	proteolipid protein 1	Homo sapiens	24-27
18261461-1	2008	The divalent cations Mg(2+), Mn(2+), Zn(2+), Ca(2+), and Ni(2+) were found to protect against proteolysis a form of GroEL (ox-GroEL) prepared by exposing GroEL for 16h to 6mM hydrogen peroxide (H(2)O(2)).	Water	194-199	heat shock protein family D (Hsp60) member 1	Homo sapiens	116-121
18261461-1	2008	The divalent cations Mg(2+), Mn(2+), Zn(2+), Ca(2+), and Ni(2+) were found to protect against proteolysis a form of GroEL (ox-GroEL) prepared by exposing GroEL for 16h to 6mM hydrogen peroxide (H(2)O(2)).	Water	194-199	heat shock protein family D (Hsp60) member 1	Homo sapiens	123-131
18261461-1	2008	The divalent cations Mg(2+), Mn(2+), Zn(2+), Ca(2+), and Ni(2+) were found to protect against proteolysis a form of GroEL (ox-GroEL) prepared by exposing GroEL for 16h to 6mM hydrogen peroxide (H(2)O(2)).	Water	194-199	heat shock protein family D (Hsp60) member 1	Homo sapiens	126-131
21202200-1	2008	In the title coordination polymer, {[Ca(C(8)H(5)Cl(2)O(3))(2)(H(2)O)(2)] H(2)O}(n), the Ca(II) atom is eight-coordinated by six O atoms from four different (2,4-dichloro-phen-oxy)acetate ligands and two water mol-ecules, and displays a distorted square-anti-prismatic coordination geometry.	Water	62-67	carbonic anhydrase 2	Homo sapiens	88-94
21202200-1	2008	In the title coordination polymer, {[Ca(C(8)H(5)Cl(2)O(3))(2)(H(2)O)(2)] H(2)O}(n), the Ca(II) atom is eight-coordinated by six O atoms from four different (2,4-dichloro-phen-oxy)acetate ligands and two water mol-ecules, and displays a distorted square-anti-prismatic coordination geometry.	Water	73-78	carbonic anhydrase 2	Homo sapiens	88-94
21202200-1	2008	In the title coordination polymer, {[Ca(C(8)H(5)Cl(2)O(3))(2)(H(2)O)(2)] H(2)O}(n), the Ca(II) atom is eight-coordinated by six O atoms from four different (2,4-dichloro-phen-oxy)acetate ligands and two water mol-ecules, and displays a distorted square-anti-prismatic coordination geometry.	Water	203-208	carbonic anhydrase 2	Homo sapiens	88-94
18411377-3	2008	ANSWER: Lead exposure through drinking tap water while breastfeeding is not associated with any serious concerns in most available studies.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
18506099-8	2008	The level of TaVp1 mRNA was high when the embryos were treated with ABA but markedly decreased in water-imbibed mature embryos whose dormancy had been broken.	Water	98-103	B3 domain-containing protein VP1	Triticum aestivum	13-18
18328444-4	2008	We investigated suppressive effects of carbohydrate fraction 1 from the water extracts of A. iwayomogi (AIP1) on the differentiation and function of bone marrow-derived dendritic cells.	Water	72-77	membrane associated guanylate kinase, WW and PDZ domain containing 2	Homo sapiens	104-108
19385472-10	2008	Placentae washed well with running tap water to remove blood clots.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
18288871-6	2008	Adsorption of CO on the Pt/C and Pt-B resulted in growth of a sharp nu(OH) band around 3642-3645 cm(-1) which is assigned to non-hydrogen-bonded water molecules coadsorbed with CO.	Water	145-150	polypyrimidine tract binding protein 1	Homo sapiens	33-37
18307293-2	2008	Previously we have described a series of novel A 2A receptor antagonists with excellent water solubility.	Water	88-93	immunoglobulin kappa variable 2D-29	Homo sapiens	47-51
18288864-0	2008	Hot water-promoted ring-opening of epoxides and aziridines by water and other nucleopliles.	Water	4-9	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
18288864-0	2008	Hot water-promoted ring-opening of epoxides and aziridines by water and other nucleopliles.	Water	62-67	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
32907180-3	2008	Au-TAsp formed discrete, water-soluble adducts with native Cyt c, whereas unfolded apoCyt c induced nanocomposite formation at high Cyt c : Au-TAsp ratios.	Water	25-30	HtrA serine peptidase 3	Homo sapiens	3-7
18371881-8	2008	The method was successfully applied to the extraction and determination of gold in tap water and silicate ore samples.	Water	87-92	nuclear RNA export factor 1	Homo sapiens	83-86
18262500-11	2008	BDNF precursor protein was significantly decreased in the synaptic fraction of trained prenatal LAAM-treated rats compared to prenatal water-treated trained controls.	Water	135-140	brain-derived neurotrophic factor	Rattus norvegicus	0-4
18194430-8	2008	The central injection of apelin in lactating rats decreases the phasic electrical activity of vasopressinergic neurones and the systemic secretion of AVP, inducing water diuresis.	Water	164-169	apelin	Rattus norvegicus	25-31
18331950-0	2008	"An adept in medicine": the Reverend Dr William Laing, nervous complaints and the commodification of spa water.	Water	105-110	surfactant protein A2	Homo sapiens	101-104
18788518-8	2008	The OR value were 1.749 for multipara, 1.995 for those going to the nearest healthcare facilities by the most convenient traffic in less than 10 minutes, 3.011 for those drinking tap water, 5.435 for those with the education of high school, 29.149 for those with over 5 times in terms of frequency of prenatal checkup and 37.822 for those being advocated on institutional delivery.	Water	183-188	nuclear RNA export factor 1	Homo sapiens	179-182
18247480-2	2008	In contrast to the long-held conjecture in the experimental literature, the computed potentials of mean force (PMF) suggest that the proton transfer in CAII is not very sensitive to the orientation of the acceptor group (His 64) and, therefore, the number of water molecules that bridge the donor (zinc-water) and acceptor groups.	Water	259-264	carbonic anhydrase 2	Homo sapiens	152-156
18247480-2	2008	In contrast to the long-held conjecture in the experimental literature, the computed potentials of mean force (PMF) suggest that the proton transfer in CAII is not very sensitive to the orientation of the acceptor group (His 64) and, therefore, the number of water molecules that bridge the donor (zinc-water) and acceptor groups.	Water	303-308	carbonic anhydrase 2	Homo sapiens	152-156
18247481-2	2008	So far, the analysis of these arrays has been restricted to freeze fracture preparations, which have shown square arrays to contain the water channel Aquaporin-4 (AQP4).	Water	136-141	aquaporin 4	Homo sapiens	163-167
18371799-10	2008	The applicability for analysing ground, lake and tap-water samples collected in the vicinity of uranium deposits was successfully demonstrated.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
18371820-0	2008	Quantitative analysis of hydrolysis of carbaryl in tap water and river by excitation-emission matrix fluorescence coupled with second-order calibration.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
18371820-1	2008	A novel method was proposed to determine simultaneously carbaryl and its degradation product 1-naphthol in river and tap water in this paper.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
18371820-5	2008	It was also applied to investigate the hydrolysis kinetics of carbaryl in river water and tap water.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
17697431-3	2008	Tap water is a major dietary source but bioavailability of organically bound iodine may be impaired.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
17697431-6	2008	Tap water contained 2 microg/l elemental iodine in Randers and 140 microg/l iodine bound in humic substances in Skagen.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
17697431-11	2008	Bioavailability of iodine in humic substances in Skagen tap water was about 85 %.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
17560643-9	2008	Independent-samples t-test results showed that there was a significant increase in the G(Ic) mean value for groups B2 and B3 after 30 days water storage (P&lt;0.05).	Water	139-144	immunoglobulin kappa variable 5-2	Homo sapiens	115-123
18348638-1	2008	Photolytic degradation of decabromodiphenyl ether (BDE 209) has been observed in several matrices such as solvent/ water mixtures, sediments, and soil; however, no studies have investigated the degradation potential of BDE 209 in house dust.	Water	115-120	homeobox D13	Homo sapiens	51-54
18156624-3	2008	Funduscopic examination revealed that EAU was induced in IL-17(-/-) mice just like in wild-type (WT) mice at early phases of the disease.	Water	38-41	interleukin 17A	Mus musculus	57-62
17884256-4	2008	TNFR1-dependent increase in aquaporin (AQP)-4 mRNA and protein expression was observed with a concomitant increase in water content, in brain (18% increase in C57Bl6 mice treated with LPS versus those treated with saline), similar to cerebral edema observed in sepsis.	Water	118-123	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	0-5
17884256-4	2008	TNFR1-dependent increase in aquaporin (AQP)-4 mRNA and protein expression was observed with a concomitant increase in water content, in brain (18% increase in C57Bl6 mice treated with LPS versus those treated with saline), similar to cerebral edema observed in sepsis.	Water	118-123	aquaporin 4	Mus musculus	28-45
18256990-4	2008	Its target antigen, aquaporin-4, the most abundant water channel in the central nervous system, has opened up new research directions into demyelinating disorders of the central nervous system.	Water	51-56	aquaporin 4	Homo sapiens	20-31
17905578-5	2008	PMMA-MWCNT(PDDA)/GOx-NFE exhibits excellent electrocatalytic activity towards hydrogen peroxide (H(2)O(2)) with a pronounced oxidation current at +100 mV.	Water	97-102	hydroxyacid oxidase 1	Homo sapiens	17-20
17963777-0	2008	Interaction of methemoglobin with GDA/n-C5H11OH/water assemblies.	Water	48-53	hemoglobin subunit gamma 2	Homo sapiens	15-28
18190202-1	2008	We report polarized infrared absorption spectra of water isotopologues isolated in solid parahydrogen (pH2) which reveal the crystal field induced splittings of the 1 01&lt;--0 00 R(0) lines in the nu1 HDO, nu3 D2O, nu3 HDO, and nu3 H2O fundamental bands.	Water	51-56	polyhomeotic homolog 2	Homo sapiens	103-106
18190202-1	2008	We report polarized infrared absorption spectra of water isotopologues isolated in solid parahydrogen (pH2) which reveal the crystal field induced splittings of the 1 01&lt;--0 00 R(0) lines in the nu1 HDO, nu3 D2O, nu3 HDO, and nu3 H2O fundamental bands.	Water	233-236	polyhomeotic homolog 2	Homo sapiens	103-106
18190202-7	2008	The spectra are consistent with water monomers existing in solid pH2 as very slightly hindered rotors.	Water	32-37	polyhomeotic homolog 2	Homo sapiens	65-68
18182788-1	2008	An essential but frequently neglected aspect of dialysis treatment is the dialysis fluid produced by blending treated tap water with concentrated solutions containing electrolytes and buffer.	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
18629448-2	2008	EAU can be induced in mice by immunization with the retinal antigen interphotoreceptor retinoid binding protein (IRBP) in complete Freund"s adjuvant (CFA) or by IRBP-pulsed mature dendritic cells, and can be driven either by a Th17 or a Th1 effector response, depending on the model.	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	113-117
18629448-2	2008	EAU can be induced in mice by immunization with the retinal antigen interphotoreceptor retinoid binding protein (IRBP) in complete Freund"s adjuvant (CFA) or by IRBP-pulsed mature dendritic cells, and can be driven either by a Th17 or a Th1 effector response, depending on the model.	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	161-165
18068107-5	2008	We investigated suppressive effects of AIP1, a water-soluble carbohydrate fraction from A. iwayomogi on ovalbumin-induced allergic asthma in BALB/c mice and studied the possible mechanisms of its anti-allergic action.	Water	47-52	actin related protein T1	Homo sapiens	39-43
18379991-4	2008	Here, we describe the self-modification underwent by heme proteins with globin-type fold, that is, myoglobin, hemoglobin, and neuroglobin when treated with NO(2) (-) or catechols in the presence of H(2)O(2).	Water	198-203	neuroglobin	Homo sapiens	126-137
19198668-11	2008	Ang-(1-7) also contributes to the enhanced water intake during pregnancy allowing maintenance of the normal volume expanded state despite diuresis.	Water	43-48	angiogenin	Rattus norvegicus	0-8
18057180-5	2008	The assay uses the Ca(2+)-sensitive fluorescence dye, Fluo-4 NW (no wash), to measure TRPM2-dependent Ca(2+) transients induced by H(2)O(2) and N-methyl-N"-nitrosoguanidine in a 96-well plate format.	Water	131-136	transient receptor potential cation channel subfamily M member 2	Homo sapiens	86-91
18983000-25	2008	At present, the most appropriate option for securing safe water for drinking and cooking is treatment of water at the tap.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	118-121
18824804-0	2008	Investigation of formaldehyde pollution of tap water and rain water using a novel visual colorimetry.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
18824804-1	2008	The pollution of tap water and rain water with formaldehyde in Toyama Pref., Japan was investigated by means of a simple, rapid and cost-effective visual colorimetry developed by us.	Water	21-26	nuclear RNA export factor 1	Homo sapiens	17-20
18824804-10	2008	It must be concerned about the pollution of rainwater with formaldehyde, when rain water is applied for tap water and miscellaneous purpose.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	104-107
18036538-5	2007	The applications to chlorinated tap water, well water, and river water have been validated.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
18052134-4	2007	The calculated results suggest a proton-transferred hydrogen bond between HO2 and H2O in H3O3+ wherein a proton is partially transferred to H2O producing the O2...H3O+ structure.	Water	140-143	H3 clustered histone 15	Homo sapiens	89-92
18220528-10	2007	The cytotoxicity of each peptide was slightly enhanced by the progressive maintenance of Abeta(1-42) and RAGE(23-54) in water over 3 weeks prior to the assay.	Water	120-125	amyloid beta precursor protein	Rattus norvegicus	89-94
17910938-0	2007	Peri-ictal water drinking in temporal lobe epilepsy: Is it a reliable lateralizing sign?	Water	11-16	perilipin 1	Homo sapiens	0-4
17910938-1	2007	Peri-ictal water drinking has been reported to be a lateralizing sign to the right side in temporal lobe epilepsy (TLE).	Water	11-16	perilipin 1	Homo sapiens	0-4
17910938-2	2007	As peri-ictal water drinking is relatively common in our own patients with TLE, we wanted to evaluate its lateralization value for ourselves.	Water	14-19	perilipin 1	Homo sapiens	3-7
17910938-4	2007	Eight patients exhibited peri-ictal water drinking behavior.	Water	36-41	perilipin 1	Homo sapiens	25-29
17910938-6	2007	We also analyzed cases of peri-ictal water drinking in the literature and found that the reported data do not support this behavior as a laterality indicator.	Water	37-42	perilipin 1	Homo sapiens	26-30
18283821-1	2007	For the swift generation of hierarchical nanostructures of CdS, we propose herein a docile microwave-induced semi-solvothermal reaction (i.e., involving simultaneous usage of nonaqueous and aqueous solvents) between cadmium acetate and thiourea in binary solution of diethylenetriamine and deionized water.	Water	300-305	phosphatidate cytidylyltransferase 1	Solanum tuberosum	59-62
18283821-8	2007	Raman spectroscopy shows the fundamental and overtone bands pertaining to hexagonal CdS with remarkable enhancement in relative intensities of such bands in case of sample corresponding to diethylenetriamine(DETA)/deionized water(DI) volume ratio of 6:1.	Water	224-229	phosphatidate cytidylyltransferase 1	Solanum tuberosum	84-87
17878564-1	2007	The toxicological risks and lifetime cancer risks of trihalomethanes through oral ingestion, dermal absorption, and inhalation exposure from tap water in selected regions in Lebanon are estimated.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
17878567-6	2007	It is predicted that airway inflammation can occur if humidifier reservoirs are filled with tap water, sometimes even at typical drinking-water distribution-system endotoxin concentrations.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
18063890-8	2007	RESULTS: Hemin, an inducer of HO-1, ameliorated the clinical signs of EAU.	Water	70-73	heme oxygenase 1	Rattus norvegicus	30-34
18055664-10	2007	Separate models were created for visits from people living in zip codes that used Lake Michigan drinking water and those who used other water sources.	Water	105-110	death associated protein kinase 3	Homo sapiens	62-65
18055664-11	2007	RESULTS: Over the 3-year study period, there was a mean of 5.0 +/- 3.8 (SD) daily visits for diarrheal illness from people who lived in zip codes that used Lake Michigan drinking water and 1.2 +/- 1.4 (SD) from outside that area.	Water	179-184	death associated protein kinase 3	Homo sapiens	136-139
17595065-2	2007	The structures, vibrational frequencies, and binding energies of 1, 2, and 3 water molecules with mercury-halide (HgBr2, HgBrCl, HgCl2, HgBr, and HgCl) and related mercury and halogen species (Br2, BrCl, Cl2, Cl, Hg, and Br) have been computed with second order Moller-Plesset perturbation theory (MP2) and the B3LYP density functional method.	Water	77-82	endogenous retrovirus group W member 5	Homo sapiens	131-134
17662298-7	2007	Arsenic adsorption in the filter from As-spiked tap water was relatively lower than that from artificial As solution because high HCO(-)(3) concentration restrained siderite dissolution and thus suppressed production of the fresh Fe oxides on the siderite grains.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
17868175-1	2007	This paper describes the development of a new method using single-drop microextraction (SDME) and RP-HPLC for the determination of decabromodiphenyl ether (BDE-209) in water samples.	Water	168-173	homeobox D13	Homo sapiens	156-159
17868175-8	2007	The proposed method is acceptable for the analysis of BDE-209 in water samples.	Water	65-70	homeobox D13	Homo sapiens	54-57
17980649-12	2007	A recent epidemiologic study found that much of the risk for bladder cancer associated with drinking water was associated with three factors: THM levels, showering/bathing/swimming (i.e., dermal/inhalation exposure), and genotype (having the GSTT1-1 gene).	Water	101-106	glutathione S-transferase theta 1	Homo sapiens	242-249
17998108-2	2007	Unlike a meso isomer, rac-2,3-DMSA is very soluble in water, strongly acidic solutions and organic solvents.	Water	54-59	Rac family small GTPase 2	Mus musculus	22-27
17890008-2	2007	The aquaporin 4 (AQP4) water channel is abundant in mammalian brain and there is a growing body of evidence suggesting that this protein plays a major role in the control of water flow within the central nervous system.	Water	23-28	aquaporin 4	Homo sapiens	4-15
17890008-2	2007	The aquaporin 4 (AQP4) water channel is abundant in mammalian brain and there is a growing body of evidence suggesting that this protein plays a major role in the control of water flow within the central nervous system.	Water	23-28	aquaporin 4	Homo sapiens	17-21
17560539-7	2007	The fluorescence results suggest that Trp1 inserts into the membrane at the lipid/water interface.	Water	82-87	transient receptor potential cation channel subfamily C member 1	Bos taurus	38-42
17600081-2	2007	The new assay, which does not require high-performance liquid chromatography (HPLC) separation or mass spectrometric detection, is based on the release of tritium as tritiated water that occurs upon CYP2C19-mediated 4"-hydroxylation of (S)-mephenytoin labeled with tritium in the 4" position.	Water	176-181	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	199-206
17803294-2	2007	EAU could be induced in susceptible animals (i.e., Lewis rat) by immune reactions using evolutionarily conserved retinal proteins, such as interphoto-receptor retinoid binding protein (IRBP), or epitaphs of the protein.	Water	0-3	retinol binding protein 3	Rattus norvegicus	139-183
17803294-2	2007	EAU could be induced in susceptible animals (i.e., Lewis rat) by immune reactions using evolutionarily conserved retinal proteins, such as interphoto-receptor retinoid binding protein (IRBP), or epitaphs of the protein.	Water	0-3	retinol binding protein 3	Rattus norvegicus	185-189
17707431-9	2007	RESULTS: Tap water as a solvent had the greatest decrease in concentration, declining below 50% by week 2 and reaching 25% by week 4.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
17707431-14	2007	Tap water solvent alone should be avoided.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
17903461-4	2007	The system allowed the re-circulation of the acceptor solution and was applied to ammonium determination in surface and tap water, providing relative standard deviations lower than 1.5%.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
17403567-6	2007	The optimum doses for decolorization (&gt;95%) of all the three dyes were found out to be 15 mgL(-1) of Fe(2+) (0.27 mM) and 50 mgL(-1) (1.47 mM) of H(2)O(2) dose at optimum pH 3.	Water	149-154	LLGL scribble cell polarity complex component 1	Homo sapiens	93-99
17416463-7	2007	Better results were achieved in a previous stage using tap water with nitrate added as a sole pollutant as a synthetic feed (critical load of 130 gNO(3)-N/(m(3)h) and denitrification rate of 200 gNO(3)-N/(m(3)h) at a nitrate load of 250 gNO(3)-N/(m(3)h)).	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
17443336-8	2007	Auto-CPAP patients used significantly more cm H2O.	Water	46-49	centromere protein J	Homo sapiens	5-9
17728016-1	2007	This study examined tap water as a source of Pseudomonas aeruginosa in a medical intensive care setting.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
17728016-5	2007	P. aeruginosa was found in 11.4% of 484 tap water samples taken from patients" rooms and in 5.3% of 189 other tap water samples (P&lt;0.01).	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
17878557-0	2007	Opportunistic Aspergillus pathogens measured in home and hospital tap water by quantitative PCR (QPCR).	Water	70-75	nuclear RNA export factor 1	Homo sapiens	66-69
17878557-3	2007	Water samples were taken from the kitchen tap in the homes of 60 patients who were diagnosed with legionellosis.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	42-45
17878557-7	2007	None of the Aspergillus species were found in any of the hospital water samples.The development of a simple DNA extraction method along with QPCR analysis is suitable for rapid screening of tap water for opportunistic fungal pathogens.	Water	194-199	nuclear RNA export factor 1	Homo sapiens	190-193
17467970-7	2007	This experimental work represents a first attempt at construction of a new carbon nanotube-tyrosinase based biosensor able to determine the concentration of BPA, one of the most ubiquitous and hazardous endocrine disruptors which can pollute the drinking and surface water, as well as many products of the food chain.	Water	267-272	tyrosinase	Homo sapiens	91-101
17693308-8	2007	This technique was successfully applied to the analysis of copper in tap water representing the first successful copper determination in real samples using the BFE.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
17608414-3	2007	The detection limit for Hg2+ was found to be 2.0 x 10(-6) M in the mixed H2O-THF system.	Water	73-76	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	24-27
17333222-0	2007	Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVA-induced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues.	Water	25-30	tyrosinase	Homo sapiens	130-140
17393298-11	2007	Additionally, we also observed an increase in c-fos mRNA expression in both PVN and SON 6 h after water deprivation, which progressively decreased 24, 48, and 72 h after the onset of water deprivation.	Water	98-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-51
17393298-11	2007	Additionally, we also observed an increase in c-fos mRNA expression in both PVN and SON 6 h after water deprivation, which progressively decreased 24, 48, and 72 h after the onset of water deprivation.	Water	183-188	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-51
17478044-1	2007	INTRODUCTION: Tap water scalds among those &gt;or=60 years old are often attributed to physical impairments with aging.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
17478044-2	2007	This study assesses socio-economics associated with tap water scalds among seniors and the elderly.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
17478044-13	2007	CONCLUSION: These findings report that tap water scalds result in significant morbidity, mortality and health care costs for local seniors and the elderly.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
17578632-2	2007	Intercellular gap junction channels, formed by at least three different connexin protein subunits, alpha1 (connexin43 or Gja1), alpha3 (connexin46 or Gja3) and alpha8 (connexin50 or Gja8), are utilized to transport metabolites, ions and water in the lens.	Water	237-242	gap junction protein alpha 8	Homo sapiens	168-178
17931998-7	2007	During procedure the patients injected tap water (300-450 ml) through the (neo-)appendicostomy with a thin catheter.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
17449664-6	2007	The p(f) matrices from molecular dynamics simulations of five aquaporins (AQP0, AQP1, AQP4, AqpZ, and GlpF) indicated that the reduction in the water correlation across the Asn-Pro-Ala region, and the small local permeability around the ar/R region, characterize the transport efficiency of water.	Water	144-149	aquaporin 4	Homo sapiens	86-90
17345571-10	2007	The reaction paths were promoted by a hydrogen-bond circuit of H3O+(H2O)2 and were determined as completely concerted processes.	Water	68-71	H3 clustered histone 15	Homo sapiens	63-66
17575980-4	2007	Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively.	Water	121-126	transient receptor potential cation channel subfamily M member 6	Homo sapiens	66-71
17575980-4	2007	Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively.	Water	121-126	solute carrier family 30 member 4	Homo sapiens	85-92
17336361-3	2007	SOD1 converts superoxide to peroxide; GPx1 converts peroxide to water.	Water	64-69	glutathione peroxidase 1	Homo sapiens	38-42
17567170-0	2007	Temperature-induced conformational transition of a model elastin-like peptide GVG(VPGVG)(3) in water.	Water	95-100	elastin	Homo sapiens	57-64
17567170-1	2007	The conformation of a single elastin-like peptide GVG(VPGVG)3 in liquid water is studied by computer simulations in the temperature interval between 280 and 440 K. Two main conformational states of the peptide can be distinguished: a rigid conformational state, dominating at low temperatures, and a flexible conformational state, dominating at high temperatures.	Water	72-77	elastin	Homo sapiens	29-36
17537436-6	2007	Fos expression was elevated in AVP-positive magnocellular PVN neurons and AVP- and corticotropin releasing hormone (CRH)-positive parvocellular PVN neurons after water restriction.	Water	162-167	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
17891956-7	2007	4-TBP was influenced by chlorine disinfection during water treatment.	Water	53-58	TATA-box binding protein	Homo sapiens	2-5
17499836-0	2007	Superparamagnetic nanoparticles in tap water.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
17403566-8	2007	for peak 1 were about 7.8x10(-10)molL(-1) and 2.59x10(-9)molL(-1), respectively, in pure electrolyte water with the relative standard deviation of 1.8% (n=7).	Water	101-106	pseudopodium enriched atypical kinase 1	Homo sapiens	4-10
17536793-2	2007	It was found that Hg2+ is hydrated by a first solvation shell of six water molecules.	Water	69-74	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	18-21
17674810-2	2007	In this communication, effects of two water-solube fullerene derivatives, fullerol and trimalonic acid C60 (TMA C60) on polymerase chain reaction (PCR) were investigated by using PCR of beta-actin cDNA derived from HeLa cells as an experimental model.	Water	38-43	POTE ankyrin domain family member F	Homo sapiens	186-196
17593005-12	2007	The splenocytes isolated from EAU- and GSNO-treated mice had lower antigen-specific T-cell proliferation in response to IRBP protein, and their cytokine production was inhibited.	Water	30-33	retinol binding protein 3, interstitial	Mus musculus	120-124
17371871-5	2007	In addition, blockade of TTF-1 synthesis increased survival of the animals following acute water intoxication-induced brain edema.	Water	91-96	transcription termination factor 1	Rattus norvegicus	25-30
17426598-4	2007	Water avoidance stimulated fecal pellet output, which was associated with Fos expression in myenteric ganglia of proximal and distal colon including in a population of peripheral choline acetyltransferase-immunoreactive neurons.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-77
17426598-4	2007	Water avoidance stimulated fecal pellet output, which was associated with Fos expression in myenteric ganglia of proximal and distal colon including in a population of peripheral choline acetyltransferase-immunoreactive neurons.	Water	0-5	choline O-acetyltransferase	Rattus norvegicus	179-204
17402708-1	2007	A novel method for the determination of hepatotoxins; microcystins (MCs), and nodularin (Nod) in lake water and domestic chlorinated tap water has been developed using liquid chromatography hyphenated with electrospray ionization triple quadrupole mass spectrometry (LC-ESI-MS/MS).	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
17402708-12	2007	The application of this LC-ESI-MS/MS method for routine screening of hepatotoxins in lake and chlorinated tap water (average Cl2=0.23 mg/L) is achieved and this study represents the first direct method for the screening of hepatotoxins in chlorinated tap water.	Water	110-115	nuclear RNA export factor 1	Homo sapiens	106-109
17495409-3	2007	This proposed method has excellent reproducibility, and was applied to recovery tests of oxalate ion in tap water and human urine; the results were satisfactory.	Water	108-113	nuclear RNA export factor 1	Homo sapiens	104-107
16953392-1	2007	INTRODUCTION: Nelarabine is a water-soluble prodrug of the cytotoxic deoxyguanosine analog ara-G, to which it is rapidly converted in vivo by adenosine deaminase.	Water	30-35	adenosine deaminase	Homo sapiens	142-161
17473188-9	2007	NPTX2 was tightly correlated with expression of the water channel aquaporin-3 (0.74, P&lt;0.0001).	Water	52-57	neuronal pentraxin 2	Homo sapiens	0-5
17596097-1	2007	When topical therapy and tap water iontophoresis (TWI) fail, are unavailable, or are deemed unsatisfactory by patients with palmar or plantar hyperhidrosis (HH), the next logical treatment option is botulinum toxin type A (BTX-A).	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
17303660-10	2007	These results suggested that the effect of AVP on water recruitment was disturbed in V1aR(-/-) mice.	Water	50-55	arginine vasopressin receptor 1A	Mus musculus	85-89
17470515-11	2007	In a subsequent study, rats were subjected to water-avoidance stress for 60 min, causing plasma gastrin to increase in WKY rats (P &lt; 0.001) but not in SPD rats.	Water	46-51	gastrin	Rattus norvegicus	96-103
17335082-1	2007	Aquaporin-4 (AQP4), the most prominent CNS water channel, is restricted to the glia limitans and astrocytic endfeet.	Water	43-48	aquaporin 4	Homo sapiens	0-11
17335082-1	2007	Aquaporin-4 (AQP4), the most prominent CNS water channel, is restricted to the glia limitans and astrocytic endfeet.	Water	43-48	aquaporin 4	Homo sapiens	13-17
17266129-1	2007	Aquaporin-4 (AQP4) is the neuromuscular water channel expressed at the sarcolemma of mammalian fast-twitch fibers that mediates a high water transport rate, which is important during muscle activity.	Water	40-45	aquaporin 4	Homo sapiens	0-11
17266129-1	2007	Aquaporin-4 (AQP4) is the neuromuscular water channel expressed at the sarcolemma of mammalian fast-twitch fibers that mediates a high water transport rate, which is important during muscle activity.	Water	40-45	aquaporin 4	Homo sapiens	13-17
17482933-14	2007	Potential causes of P. aeruginosa contamination include the lack of adequate manual cleaning before disinfection, failure to sterilize the needle guide, and the use of a tap-water rinse after disinfection.	Water	174-179	nuclear RNA export factor 1	Homo sapiens	170-173
17407569-10	2007	We suggest that the experimental differences in binding energetics can be at least partially ascribed to the absence in the R21A Spc-SH3:P41 complex of several buried water molecules, which have been proposed previously to contribute largely to the highly negative enthalpy and entropy of binding in the Abl-SH3:P41 complex.	Water	167-172	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	304-307
17158258-2	2007	Compared with CCK-8, CCK-58 is a much stronger stimulant of pancreatic chloride and water secretion, equivalent to maximally effective secretin, but with a chloride-to-bicarbonate ratio characteristic of acinar fluid.	Water	84-89	cholecystokinin	Rattus norvegicus	21-24
17158258-10	2007	We hypothesize that supramaximal CCK-58 does not induce pancreatitis because it maintains pancreatic acinar chloride and water secretion, which are essential for exocytosis of activated zymogens.	Water	121-126	cholecystokinin	Rattus norvegicus	33-36
17079781-3	2007	Previously we demonstrated that in cultured mouse lung epithelial cells exposed to bolus administration of H(2)O(2), TNF-alpha-induced NF-kappaB activity was inhibited, whereas c-Jun-N-terminal kinase (JNK) activation was enhanced via a mechanism involving TNF receptor-1 (TNF-RI).	Water	107-112	mitogen-activated protein kinase 8	Mus musculus	177-200
17079781-3	2007	Previously we demonstrated that in cultured mouse lung epithelial cells exposed to bolus administration of H(2)O(2), TNF-alpha-induced NF-kappaB activity was inhibited, whereas c-Jun-N-terminal kinase (JNK) activation was enhanced via a mechanism involving TNF receptor-1 (TNF-RI).	Water	107-112	mitogen-activated protein kinase 8	Mus musculus	202-205
17079781-3	2007	Previously we demonstrated that in cultured mouse lung epithelial cells exposed to bolus administration of H(2)O(2), TNF-alpha-induced NF-kappaB activity was inhibited, whereas c-Jun-N-terminal kinase (JNK) activation was enhanced via a mechanism involving TNF receptor-1 (TNF-RI).	Water	107-112	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	273-279
17123683-8	2007	There were no statistical differences among these groups except isotonic saline, at 3min post-exposure (in wash solutions), showed a significantly difference (p&lt;0.05) when compared to tap water.	Water	191-196	nuclear RNA export factor 1	Homo sapiens	187-190
16969383-9	2007	The potential for in vivo magnetic resonance mapping of water permeability was showed using two diffusion weighted ASL measurements with b=0 and 50 secs/mm2 in both healthy subjects and a case of brain tumor.	Water	56-61	PNMA family member 2	Homo sapiens	153-156
17439296-4	2007	The binding sites of this autoantibody were reported to colocalize with aquaporin 4 (AQP4) water channels.	Water	91-96	aquaporin 4	Homo sapiens	72-83
17439296-4	2007	The binding sites of this autoantibody were reported to colocalize with aquaporin 4 (AQP4) water channels.	Water	91-96	aquaporin 4	Homo sapiens	85-89
17439296-9	2007	CONCLUSIONS: In the largest series reported so far to our knowledge, we quantified AQP4 antibodies in patients with NMO versus various other diseases, and showed that the aquaporin 4 water channel is a target antigen in a majority of patients with NMO.	Water	183-188	aquaporin 4	Homo sapiens	83-87
17439296-9	2007	CONCLUSIONS: In the largest series reported so far to our knowledge, we quantified AQP4 antibodies in patients with NMO versus various other diseases, and showed that the aquaporin 4 water channel is a target antigen in a majority of patients with NMO.	Water	183-188	aquaporin 4	Homo sapiens	171-182
17106661-6	2007	Our study demonstrated the superiority of arsenical ferruginous spa therapy compared to short wave therapy in the treatment of osteoarthritis of the knee, probably in relationship to the specific effects of the minerals in this water.	Water	228-233	surfactant protein A2	Homo sapiens	64-67
16938388-10	2007	It was noticed that tap water has no effect in leaching of arsenic from CalSiCo-sludge but rain water causes significant amount of leaching, which is mostly due to pH effect.	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
16987594-1	2007	TiO(2) photocatalyst (P-25) (50mgL(-1)) was tentatively introduced into pulsed high-voltage discharge process for non-thermal plasma-induced photocatalytic degradation of the representative mode organic pollutant parachlorophenol (4-CP), including other compounds phenol and methyl red in water.	Water	289-294	tubulin polymerization promoting protein	Homo sapiens	22-26
17237925-4	2007	Addition of sodium thiosulfate to tap water prevented pyrethroid degradation as a result of oxidation by free chlorine.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
17375781-6	2007	Burns by child abuse occur mostly from tap water (50%) and usually in children less than 2 years old.	Water	43-48	nuclear RNA export factor 1	Homo sapiens	39-42
18240489-8	2007	The amount of water flowing through the tap per minute was also recorded.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	40-43
17158169-2	2007	In the present paper we investigated the relation between sugar and water transport in human GLUT2 expressed in Xenopus oocytes.	Water	68-73	solute carrier family 2 member 2	Homo sapiens	93-98
17402560-9	2007	Administration of anti-IL-12 mAb at the time of IRBP immunization completely inhibited development of EAU, and antagonistic anti B7RP-1 mAb suppressed the severity of EAU even when administered after development of EAU.	Water	167-170	inducible T cell costimulator ligand	Homo sapiens	129-135
17360692-0	2007	Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex.	Water	51-56	aquaporin 5	Mus musculus	84-95
17260973-1	2007	Gamma-glutamyl transpeptidase (GGT, EC 2.3.2.2) catalyzes the transfer of the gamma-glutamyl group of glutathione and related gamma-glutamyl amides to water (hydrolysis) or to amino acids and peptides (transpeptidation) and plays a central role in glutathione metabolism.	Water	151-156	inactive glutathione hydrolase 2	Homo sapiens	0-29
17260973-1	2007	Gamma-glutamyl transpeptidase (GGT, EC 2.3.2.2) catalyzes the transfer of the gamma-glutamyl group of glutathione and related gamma-glutamyl amides to water (hydrolysis) or to amino acids and peptides (transpeptidation) and plays a central role in glutathione metabolism.	Water	151-156	inactive glutathione hydrolase 2	Homo sapiens	31-34
17240206-1	2007	The present study demonstrates that H(2)O(2) and OH(.-) cause fibril aggregation and catalytic inactivation of porcine fumarase.	Water	36-42	fumarate hydratase	Homo sapiens	119-127
17249828-1	2007	The potential energy surfaces (PESs) and associated energy barriers that characterize the spin-forbidden recombination reactions of the gas-phase ferrous deoxy-heme group with CO, NO, and H2O ligands have been calculated using density functional theory (DFT).	Water	188-191	spindlin 1	Homo sapiens	90-94
17255419-5	2007	Patients drank 800-1000 mL of tap water to establish a background for dynamic contrast-enhanced CT scans.	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
17365576-6	2007	When arsenic intake from consumption of tap water and beverages made from tap water (microg/L arsenic x L/d = microg/d) was used as a predictor variable, the correlation was markedly increased for individuals with &gt;1 microg/L arsenic (R2 = .48).	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
17365576-6	2007	When arsenic intake from consumption of tap water and beverages made from tap water (microg/L arsenic x L/d = microg/d) was used as a predictor variable, the correlation was markedly increased for individuals with &gt;1 microg/L arsenic (R2 = .48).	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
17198438-8	2007	Thus, we have determined the following equilibrium constant by the kinetic method: (SCN)2 + H2O HOSCN + SCN- + H+; Khyd = [HOSCN][SCN-][H+]/[(SCN)2] = khyd/kcomp = 19.8(+/-0.7) s-1/ 5.14(+/-0.07) x 103 M-2 s-1 = 3.9 x 10-3 M2.	Water	92-95	growth factor independent 1 transcriptional repressor	Homo sapiens	84-89
17198438-8	2007	Thus, we have determined the following equilibrium constant by the kinetic method: (SCN)2 + H2O HOSCN + SCN- + H+; Khyd = [HOSCN][SCN-][H+]/[(SCN)2] = khyd/kcomp = 19.8(+/-0.7) s-1/ 5.14(+/-0.07) x 103 M-2 s-1 = 3.9 x 10-3 M2.	Water	92-95	growth factor independent 1 transcriptional repressor	Homo sapiens	142-147
17185419-6	2007	Deprotonation of a water molecule by the highly conserved residue betaHis-265, as proposed for threonyl-tRNA synthetase, was excluded because replacement of this and neighboring residues had little effect on editing activity.	Water	19-24	threonyl-tRNA synthetase 1	Homo sapiens	95-119
16990491-0	2007	Molecular characterization of water-selective AQP (EbAQP4) in hagfish: insight into ancestral origin of AQP4.	Water	30-35	aquaporin 4	Homo sapiens	53-57
16990491-10	2007	These observations suggest that EbAQP4 is an ancestral water channel of mammalian AQP4 and plays a role in basolateral water transport in the gill pavement cells.	Water	55-60	aquaporin 4	Homo sapiens	34-38
16990491-10	2007	These observations suggest that EbAQP4 is an ancestral water channel of mammalian AQP4 and plays a role in basolateral water transport in the gill pavement cells.	Water	119-124	aquaporin 4	Homo sapiens	34-38
18273386-10	2007	They interact indirectly with copper(II) through water molecules as the result of dominant syn conformation of purine.	Water	49-54	synemin	Homo sapiens	91-94
17284903-3	2007	Since aquaporin-4 (AQP4) is a water channel with an enormous water flux capacity, we investigated in this study whether this water channel protein might play a role in myocyte swelling following myocardial infarction.	Water	30-35	aquaporin 4	Mus musculus	6-17
17284903-3	2007	Since aquaporin-4 (AQP4) is a water channel with an enormous water flux capacity, we investigated in this study whether this water channel protein might play a role in myocyte swelling following myocardial infarction.	Water	30-35	aquaporin 4	Mus musculus	19-23
19170255-0	2007	Distribution of the AQP4 water channel in normal human tissues: protein and tissue microarrays reveal expression in several new anatomical locations, including the prostate gland and seminal vesicles.	Water	25-30	aquaporin 4	Homo sapiens	20-24
19170255-2	2007	Aquaporin 4 (AQP4) is a major water channel in the central nervous system where it participates in cerebral water balance.	Water	30-35	aquaporin 4	Homo sapiens	0-11
19170255-2	2007	Aquaporin 4 (AQP4) is a major water channel in the central nervous system where it participates in cerebral water balance.	Water	30-35	aquaporin 4	Homo sapiens	13-17
19170255-2	2007	Aquaporin 4 (AQP4) is a major water channel in the central nervous system where it participates in cerebral water balance.	Water	108-113	aquaporin 4	Homo sapiens	0-11
19170255-2	2007	Aquaporin 4 (AQP4) is a major water channel in the central nervous system where it participates in cerebral water balance.	Water	108-113	aquaporin 4	Homo sapiens	13-17
16957940-1	2007	Like humans, the heart rate (HR) of anesthetized rats immersed in CO(2)-water is lower than that when immersed in tap water at the same temperature.	Water	118-123	SEC14-like lipid binding 2	Rattus norvegicus	114-117
16957940-3	2007	The animals were immersed up to the axilla in a bathtub of tap-water (CO(2) contents: 10-20 mg.l(-1)) or of CO(2)-water (965-1,400 mg.l(-1)) at 35 degrees C while recording HR, arterial blood pressure, and arterial blood gas parameters (PaCO(2), PaO(2), pH).	Water	63-68	SEC14-like lipid binding 2	Rattus norvegicus	59-62
18350978-0	2007	Chemical contamination of potable water in ship tanks.	Water	34-39	inositol polyphosphate-5-phosphatase D	Homo sapiens	43-47
17890843-0	2007	Estimation of the consumption of cold tap water for microbiological risk assessment: an overview of studies and statistical analysis of data.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
17890843-1	2007	The volume of cold tap water consumed is an essential element in quantitative microbial risk assessment.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
17890843-2	2007	This paper presents a review of tap water consumption studies.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
17954255-4	2007	The lipid phosphate phosphatase activities of DPP1-encoded and LPP1-encoded enzymes are measured by following the release of water-soluble radioactive inorganic phosphate from chloroform-soluble radioactive lipid phosphate substrate following a chloroform/methanol/water phase partition.	Water	125-130	bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase	Saccharomyces cerevisiae S288C	46-50
17954255-4	2007	The lipid phosphate phosphatase activities of DPP1-encoded and LPP1-encoded enzymes are measured by following the release of water-soluble radioactive inorganic phosphate from chloroform-soluble radioactive lipid phosphate substrate following a chloroform/methanol/water phase partition.	Water	265-270	bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase	Saccharomyces cerevisiae S288C	46-50
17704635-1	2007	The objective of this study was to investigate the potential of repetitive extragenic palindromic anchored polymerase chain reaction (rep-PCR) in differentiating fecal Escherichia coli isolates of human, domestic- and wild-animal origin that might be used as a molecular tool to identify the possible source(s) of fecal pollution of source water.	Water	340-345	replication protein	Escherichia coli	64-67
17704635-4	2007	These results suggest that rep-PCR DNA fingerprinting procedures can be used as a source tracking tool for detection of human- as well as animal-derived fecal contamination of water.	Water	176-181	replication protein	Escherichia coli	27-30
17074507-1	2007	The role of aquaporin-4 in water transport has been extensively investigated, while little information exists regarding its contribution to astrocytic functions such as the action to glutamatergic transmission.	Water	27-32	aquaporin 4	Mus musculus	12-23
17822335-6	2007	The LPL expression was increased in the heart of mice given ethanol and HF diet compared to mice on chow and ethanol (p&lt;0.001) and was also increased in epididymal fat in mice given ethanol and HF diet compared to mice on water and HF diet (p&lt;0.05).	Water	225-230	lipoprotein lipase	Mus musculus	4-7
17455864-8	2007	Other potential risk factors for bladder cancer are other urinary tract infections and drinking tap water with chlorination by-products or arsenic.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
17425085-9	2007	When flushed with tap water, nitrogen and phosphorus were retained by the vegetated mesocosms, but leached from the non-vegetated mesocosms.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
17489391-6	2007	A stepwise regression technique was employed to correlate 2-MIB and microcystins concentrations with all the corresponding water quality and meteorological parameters.	Water	123-128	MIB E3 ubiquitin protein ligase 1	Homo sapiens	60-63
17489391-7	2007	Correlations among 2-MIB concentration, microcystin concentration, water temperature and air temperature were found in the water samples collected from both reservoirs.	Water	123-128	MIB E3 ubiquitin protein ligase 1	Homo sapiens	21-24
17489396-3	2007	A case study that uses untrained citizens to monitor chlorine flavour of tap water is presented.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
17489401-2	2007	Since the reported odour thresholds of geosmin and 2-MIB are as low as 4 and 8.5 ng/L, respectively, they are not readily removed by conventional water treatment processes.	Water	146-151	MIB E3 ubiquitin protein ligase 1	Homo sapiens	53-56
17489406-7	2007	Water samples stored in the epoxy-lined pipes showed a significant increase in the leaching of organic compounds (as TOC), and this TOC was demonstrated to react with free chlorine to form trichloromethane.	Water	0-5	rhomboid 5 homolog 2	Homo sapiens	117-120
17489406-7	2007	Water samples stored in the epoxy-lined pipes showed a significant increase in the leaching of organic compounds (as TOC), and this TOC was demonstrated to react with free chlorine to form trichloromethane.	Water	0-5	rhomboid 5 homolog 2	Homo sapiens	132-135
17489417-1	2007	The most common compounds responsible for off flavours are geosmin, 2-MIB, and nonadienal which are poorly removed by conventional water treatment operations and hence result in customer complaints.	Water	131-136	MIB E3 ubiquitin protein ligase 1	Homo sapiens	70-73
17489418-6	2007	In addition, water utilities can characterise their tap water flavour, track it for changes and correlate changes to customer complaints.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	52-55
17489418-6	2007	In addition, water utilities can characterise their tap water flavour, track it for changes and correlate changes to customer complaints.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	52-55
17489422-6	2007	Therefore, dechlorinated tap water may be the best background water to use for a particular drinking water evaluation of chlorine and chloramine thresholds.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
17489422-6	2007	Therefore, dechlorinated tap water may be the best background water to use for a particular drinking water evaluation of chlorine and chloramine thresholds.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	25-28
17849979-4	2007	A pilot scale hollow fibre MBR system of 220 L was fed by adequately diluting white wine with tap water, simulating wastewaters generated in wineries.	Water	98-103	nuclear RNA export factor 1	Homo sapiens	94-97
18350712-4	2007	The Polish Committee of Standards (Polski Komitet Normalizacyjny--PKN) recommends the performance of sensitivity taste examinations with the use of method based on rinsing out the mouth with water solutions of taste substances (sip-and-spit method) at their growing concentrations.	Water	191-196	protein kinase N1	Homo sapiens	66-69
17097063-1	2006	Aquaporin-5 (AQP5) is a water-selective channel protein that is expressed in lacrimal glands, salivary glands, and distal lung.	Water	24-29	aquaporin 5	Mus musculus	0-11
17097063-1	2006	Aquaporin-5 (AQP5) is a water-selective channel protein that is expressed in lacrimal glands, salivary glands, and distal lung.	Water	24-29	aquaporin 5	Mus musculus	13-17
17097063-2	2006	Several studies using AQP5 knockout mice have revealed that AQP5 plays an important role in maintaining water homeostasis in the lung.	Water	104-109	aquaporin 5	Mus musculus	22-26
17097063-2	2006	Several studies using AQP5 knockout mice have revealed that AQP5 plays an important role in maintaining water homeostasis in the lung.	Water	104-109	aquaporin 5	Mus musculus	60-64
17081500-1	2006	Since our experimental results suggest that UT-B1 functions as active water transporter against osmotic gradient in C6 glial cells, we report here for the first time the evidence for the active water transport.	Water	70-75	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	44-49
17081500-6	2006	Taken together, these observations indicate that UT-B1 acts as an active water transporter, providing a new model on active water transport.	Water	73-78	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	49-54
17180999-4	2006	The concentration of noroviruses in tap water was estimated based on qualitative data and a most probable number (MPN) method with an assumed Poisson lognormal distribution.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
17180999-5	2006	This numerical method was evaluated using two sets of available count data of Cryptosporidium: that collected from a river and that found in tap water in Japan.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
17011626-1	2006	Yeast cytochrome c peroxidase (CCP) efficiently catalyzes the reduction of H(2)O(2) to H(2)O by ferrocytochrome c in vitro.	Water	75-80	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	6-29
17011626-1	2006	Yeast cytochrome c peroxidase (CCP) efficiently catalyzes the reduction of H(2)O(2) to H(2)O by ferrocytochrome c in vitro.	Water	75-80	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	31-34
17089035-1	2006	A water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia (MAK) has been shown to exert a potent chemopreventive effect.	Water	2-7	male germ cell-associated kinase	Rattus norvegicus	88-91
17125375-1	2006	A highly efficient photocatalytic system for hydrogen evolution with dihydronicotinamide coenzyme (NADH) as a sacrificial agent in an aqueous solution has been constructed by using water-soluble platinum clusters functionalized with methyl viologen-alkanethiol (MVA2+) and a simple electron-donor dyad, 9-mesityl-10-methylacridinium ion (Acr+-Mes), which is capable of fast photoinduced electron transfer but extremely slow back electron transfer.	Water	181-186	centrosomal protein 57	Homo sapiens	262-266
16871401-3	2006	The present study examines, by gel electrophoresis and Western blotting, the expression levels of the water channels aquaporin 1 (AQP1) and aquaporin 4 (AQP4) in the frontal cortex (area 8) homogenates of sporadic CJD cases (six men, four women; seven cases with methionine/methionine at codon 129 and PrP type 1; two cases with valine/valine at codon 129 and PrP type 2, and one case methionine/valine at codon 129 and PrP type 1) compared with age-matched controls, and cases with Alzheimer"s disease (AD, stage VI of Braak and Braak) and diffuse Lewy body disease (DLB).	Water	102-107	aquaporin 4	Homo sapiens	153-157
16788141-10	2006	Water diuresis did not change UT-A1 but decreased AQP2 and NKCC2/BSC1 abundances.	Water	0-5	solute carrier family 12 member 1	Rattus norvegicus	59-64
16788141-10	2006	Water diuresis did not change UT-A1 but decreased AQP2 and NKCC2/BSC1 abundances.	Water	0-5	solute carrier family 12 member 1	Rattus norvegicus	65-69
16950829-9	2006	Identification of the enzymes as tyrosinases was confirmed by the ability of lichen thalli or leachates derived by shaking lichens in distilled water to metabolize substrates such as L-dihydroxyphenylalanine (DOPA), tyrosine and epinephrine readily in the absence of hydrogen peroxide, the sensitivity of the enzymes to the inhibitors cyanide, azide and hexylresorcinol, activation by SDS and having typical tyrosinase molecular masses of approx.	Water	144-149	tyrosinase	Homo sapiens	33-43
17185514-5	2006	Ca(2+)/calmodulin kinase II (CaMKII) is markedly phosphorylated after the forced swimming test and the training trial of water finding test in the prefrontal cortex of saline-treated mice but not PCP-treated mice.	Water	121-126	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	29-35
16988006-2	2006	Oral administration of the MDT-1 strain (10(9) CFU/dose) alleviated the symptoms of colitis (including body weight loss, diarrhea, bloody stool, organic disorder, and mucosal damage) that are induced in mice drinking water that contains 3.0% dextran sulfate sodium.	Water	217-222	retinol dehydrogenase 11	Mus musculus	27-32
17039566-3	2006	ICOS expression was found on infiltrating CD4+ T cells in the region of the retina in EAU-induced mice.	Water	86-89	inducible T cell co-stimulator	Mus musculus	0-4
18404470-1	2006	Cytosolic 5" nucleotidase II (cN-II) catalyses both the hydrolysis of a number of nucleoside monophosphates (e.g., IMP + H2O--&gt; inosine + Pi), and the phosphate transfer from a nucleoside monophosphate donor to the 5" position of a nucleoside acceptor (e.g., IMP + guanosine --&gt; inosine + GMP).	Water	121-124	5'-nucleotidase, cytosolic II	Homo sapiens	0-28
18404470-1	2006	Cytosolic 5" nucleotidase II (cN-II) catalyses both the hydrolysis of a number of nucleoside monophosphates (e.g., IMP + H2O--&gt; inosine + Pi), and the phosphate transfer from a nucleoside monophosphate donor to the 5" position of a nucleoside acceptor (e.g., IMP + guanosine --&gt; inosine + GMP).	Water	121-124	5'-nucleotidase, cytosolic II	Homo sapiens	30-35
17042514-2	2006	Fibrils of the short peptide TTR105-115 were encapsulated inside water droplets of a water-in-perfluorocarbon oil emulsion and retained their rod morphology.	Water	65-70	transthyretin	Homo sapiens	29-32
17042514-2	2006	Fibrils of the short peptide TTR105-115 were encapsulated inside water droplets of a water-in-perfluorocarbon oil emulsion and retained their rod morphology.	Water	85-90	transthyretin	Homo sapiens	29-32
17004751-4	2006	B3LYP/6-31+G(d,p) calculations on model clusters designed to mimic both Bronsted and Lewis sites validate the assignments, showing that water adsorbed on the surface Lewis site, when interacting with CO, shows an acidity comparable to that of a classical zeolitic Bronsted site.	Water	136-141	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	2-5
17415434-0	2006	Negative chronotropic effect of cannabinoids and their water-soluble emulsion is related to activation of cardiac CB1 receptors.	Water	55-60	cannabinoid receptor 1	Rattus norvegicus	114-117
17144261-3	2006	The volumetric oxygen transfer coefficient (kLa) values for superficial air velocities between 8.4 cm min(-1) and 57.0 cm min(-1) varied from 20.8 h(-1) to 58.8 h(-1) for tap water, and 16.8 h(-1) to 53.0 h(-1) for the anaerobic pre-treated effluent.	Water	175-180	nuclear RNA export factor 1	Homo sapiens	171-174
16787644-1	2006	Atrial natriuretic peptide (ANP) is a regulator of the water and electrolyte content in the brain which also mediates cell volume homeostasis.	Water	55-60	natriuretic peptide A	Rattus norvegicus	0-26
16787644-1	2006	Atrial natriuretic peptide (ANP) is a regulator of the water and electrolyte content in the brain which also mediates cell volume homeostasis.	Water	55-60	natriuretic peptide A	Rattus norvegicus	28-31
16982516-7	2006	The concentration of iodoacetic acid in tap water samples boiled with 2 g l-1 of iodized table salt was found to be in the 1.5 microg l-1 range, whilst the concentration of chloroiodoacetic acid was estimated to be three to five times lower.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	40-43
16990176-6	2006	In children aged 1 - 13, the only significant risk factor was the consumption of at-risk tap water (i.e., filtered or unfiltered surface water or unfiltered shallow well water; OR = 6.13).	Water	93-98	nuclear RNA export factor 1	Homo sapiens	89-92
16990176-6	2006	In children aged 1 - 13, the only significant risk factor was the consumption of at-risk tap water (i.e., filtered or unfiltered surface water or unfiltered shallow well water; OR = 6.13).	Water	137-142	nuclear RNA export factor 1	Homo sapiens	89-92
16990176-6	2006	In children aged 1 - 13, the only significant risk factor was the consumption of at-risk tap water (i.e., filtered or unfiltered surface water or unfiltered shallow well water; OR = 6.13).	Water	137-142	nuclear RNA export factor 1	Homo sapiens	89-92
17225816-1	2006	OBJECTIVES: Due to increased consumption of pre-packaged drinks, tap water may no longer be the principal source of water intake and consequently fluoride intake.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
17225816-1	2006	OBJECTIVES: Due to increased consumption of pre-packaged drinks, tap water may no longer be the principal source of water intake and consequently fluoride intake.	Water	116-121	nuclear RNA export factor 1	Homo sapiens	65-68
17225816-8	2006	Tap water, fruit squashes and cordials (extremely sweet non-alcoholic fruit flavoured drink concentrates) prepared with tap water, as well as cooked rice, pasta and vegetables were important sources of fluoride in optimally and sub-optimally fluoridated areas.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
17225816-8	2006	Tap water, fruit squashes and cordials (extremely sweet non-alcoholic fruit flavoured drink concentrates) prepared with tap water, as well as cooked rice, pasta and vegetables were important sources of fluoride in optimally and sub-optimally fluoridated areas.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	0-3
17225816-8	2006	Tap water, fruit squashes and cordials (extremely sweet non-alcoholic fruit flavoured drink concentrates) prepared with tap water, as well as cooked rice, pasta and vegetables were important sources of fluoride in optimally and sub-optimally fluoridated areas.	Water	124-129	nuclear RNA export factor 1	Homo sapiens	120-123
16999495-1	2006	In this work, using quantum partial charges, computed from 6-31G(**)B3LYP density functional theory, in molecular dynamics simulations, we found that water inside (6,6) and (10,0) single-walled carbon nanotubes with similar diameters but with different chiralities has remarkably different structural and dynamical properties.	Water	150-155	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	70-73
16807956-5	2006	The structures as determined by X-ray crystallography of the hCA II-l-His/d-His adducts showed the activators to be anchored at the entrance of the active site, contributing to extended networks of hydrogen bonds with amino acid residues/water molecules present in the cavity, explaining their different potency and interaction patterns with various isozymes.	Water	238-243	carbonic anhydrase 2	Homo sapiens	61-67
16970300-9	2006	The electrode was applicable for analysis of spiked arsenic in tap water containing a significant amount of various ion elements.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
16924288-1	2006	How secondary bonds can influence the coordination environment of Ag(I): the role of coordinated water in [Ag2(mu-L)2(OH2)2](OTf)2.	Water	97-102	POU class 2 homeobox 2	Homo sapiens	125-130
16840540-4	2006	The mineralized water was designed to mimic the composition of a typical tap water.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	73-76
16837174-0	2006	Keratin-rhamnolipids and keratin-sodium dodecyl sulfate interactions at the air/water interface.	Water	80-85	keratin	Gallus gallus	0-32
17366771-4	2006	The mean total arsenic (microg/L) in tap-water was 20.3+/-3.7 in Ajo and 4.0+/-2.3 in Tucson.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
16877037-3	2006	Based on the fluorescence quenching of Tb/acac/PAM by Cr (VI), a method for the selective determination of Cr (VI), without separation of Cr (III) in water, was developed.	Water	150-155	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	47-50
16913708-1	2006	The crystal structure of the vitamin D receptor (VDR) in complex with 1 alpha,25(OH)2D3 revealed the presence of several water molecules near the A-ring linking the ligand C-2 position to the protein surface.	Water	121-126	vitamin D receptor	Homo sapiens	29-47
16913708-1	2006	The crystal structure of the vitamin D receptor (VDR) in complex with 1 alpha,25(OH)2D3 revealed the presence of several water molecules near the A-ring linking the ligand C-2 position to the protein surface.	Water	121-126	vitamin D receptor	Homo sapiens	49-52
16557501-1	2006	We have investigated the possible proton transfer pathways from the surface of the protein to the zinc-bound water molecule in the mutant His-64-Ala of human carbonic anhydrase II.	Water	109-114	carbonic anhydrase 2	Homo sapiens	158-179
16797122-1	2006	Aquaporin-4 (AQP4) is the predominant water channel of brain, which mediates transmembrane water movement at the blood-brain barrier and at the brain-cerebrospinal fluid interface.	Water	38-43	aquaporin 4	Mus musculus	0-11
16797122-1	2006	Aquaporin-4 (AQP4) is the predominant water channel of brain, which mediates transmembrane water movement at the blood-brain barrier and at the brain-cerebrospinal fluid interface.	Water	38-43	aquaporin 4	Mus musculus	13-17
16797122-1	2006	Aquaporin-4 (AQP4) is the predominant water channel of brain, which mediates transmembrane water movement at the blood-brain barrier and at the brain-cerebrospinal fluid interface.	Water	91-96	aquaporin 4	Mus musculus	0-11
16797122-1	2006	Aquaporin-4 (AQP4) is the predominant water channel of brain, which mediates transmembrane water movement at the blood-brain barrier and at the brain-cerebrospinal fluid interface.	Water	91-96	aquaporin 4	Mus musculus	13-17
16814974-1	2006	Aquaporin-1 and aquaporin-4, water channel membrane proteins reported in both experimental animals and in adult humans, have been detected in different, non-overlapping areas of the central nervous system.	Water	29-34	aquaporin 4	Homo sapiens	16-27
16814974-10	2006	These results in human fetal brain lend morphological support to the previous findings that aquaporin-1 and aquaporin-4 play different roles in the regulation of the water homeostasis of the brain.	Water	166-171	aquaporin 4	Homo sapiens	108-119
16814839-9	2006	Exposure to recreational water increased the incidence of respiratory illnesses for the whole population almost by a factor 2.	Water	25-30	transcription termination factor 2	Homo sapiens	117-125
16928296-2	2006	The expression changes of gp96 in K562 cell line was detected by immunocytochemistry under 38, 40, 42, 44, 46 and 48 degrees C for 30 minutes in water, by flow cytometry under 40, 44, 48 and 52 degrees C for 30 minutes in water, by Western blot under 40, 44, 48 and 52 degrees C for 30 minutes in water.	Water	145-150	heat shock protein 90 beta family member 1	Homo sapiens	26-30
16928296-4	2006	The peak of gp96 expression was at 30 minutes after 48 degrees C in water.	Water	68-73	heat shock protein 90 beta family member 1	Homo sapiens	12-16
16928296-7	2006	In conclusion, the expression of gp96 in K562 cell line reached peak at 30 minutes after 48 degrees C in water.	Water	105-110	heat shock protein 90 beta family member 1	Homo sapiens	33-37
16842013-5	2006	The bond dissociation energy (BDE) of the O-H bond formed upon reduction to [Fe(II)(PY5)(H2O)]2+ is estimated to be 80 kcal mol(-1), 2 kcal mol(-1) lower than that in the structurally analogous [Mn(II)(PY5)(H2O)]2+ complex, supporting the generally accepted idea that Mn(III) is the thermodynamically superior oxidant at parity of coordination sphere.	Water	89-92	homeobox D13	Homo sapiens	30-33
16842013-5	2006	The bond dissociation energy (BDE) of the O-H bond formed upon reduction to [Fe(II)(PY5)(H2O)]2+ is estimated to be 80 kcal mol(-1), 2 kcal mol(-1) lower than that in the structurally analogous [Mn(II)(PY5)(H2O)]2+ complex, supporting the generally accepted idea that Mn(III) is the thermodynamically superior oxidant at parity of coordination sphere.	Water	89-93	homeobox D13	Homo sapiens	30-33
16834346-5	2006	We have performed molecular dynamics simulations on the U1A-RNA complex, including explicit water and counterions, and analyzed the results based on the calculated positional cross-correlations of atomic fluctuations.	Water	92-97	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	56-59
16677726-2	2006	Male and female C57BL/6 mice that lack the gene for oxytocin (OT KO mice) displayed an initial and sustained enhanced intake of sucrose solution over water compared to wild type (WT) mice when the solutions were presented as a two-bottle choice [Amico JA, Vollmer RR, Cai HM, Miedlar JA, Rinaman R. Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion.	Water	150-155	oxytocin	Mus musculus	52-60
16817749-12	2006	CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that, in this rapid-evolving, dilated cardiomyopathy, activation of the renin-angiotensin system contributes to the pathophysiology of heart failure late in the disease and essentially by an activation of renal salt and water retention.	Water	272-277	renin	Canis lupus familiaris	124-129
16836953-2	2006	Diagnostic testing and long-term treatment are best initiated after disimpaction has been achieved, by large-volume tap water enemas and/or oral colonic lavage with polyethylene glycol.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
16740415-0	2006	Common RAPD pattern of Pseudomonas aeruginosa from patients and tap water in a medical intensive care unit.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
16834432-4	2006	It was found that RecA disassembly commenced from multiple sites both in deionized water and in buffer; the areas where RecA dissociated showed the appearance of "gaps" in the filamentous structure.	Water	83-88	RAD51 recombinase	Homo sapiens	18-22
16834432-7	2006	RecA hexamers and monomers were observed in deionized water and in buffer, respectively, during the disassembly process.	Water	54-59	RAD51 recombinase	Homo sapiens	0-4
16763307-2	2006	The Ca(II) cation, lying on a twofold axis, is coordinated by two water molecules and six malonate O atoms.	Water	66-71	carbonic anhydrase 2	Homo sapiens	4-10
16700706-4	2006	Those who had drunk tap water had a three-fold increased risk for illness (95% CI 2.4-4.0).	Water	24-29	nuclear RNA export factor 1	Homo sapiens	20-23
16917709-5	2006	The highest levels of salinity was evident in tap water.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
16796591-3	2006	Both patients fulfilled the clinical criteria of NMO, however, NMO-IgG, autoantibody against aquaporin-4 water channel, was absent from their sera.	Water	105-110	aquaporin 4	Homo sapiens	93-104
16609960-1	2006	alpha-Syntrophin, a member of the dystrophin-associated protein complex, is required for proper localization of the water channel aquaporin-4 at the blood-brain barrier.	Water	116-121	aquaporin 4	Homo sapiens	130-141
16899467-1	2006	Water channel aquaporin 5 (AQP5) is present in the apical membrane of the salivary gland acinar cells.	Water	0-5	aquaporin 5	Mus musculus	14-25
16899467-1	2006	Water channel aquaporin 5 (AQP5) is present in the apical membrane of the salivary gland acinar cells.	Water	0-5	aquaporin 5	Mus musculus	27-31
16768129-5	2006	Recently, AQP4 and AQP9 have been reported to involve in the brain water accumulation in the brain edema.	Water	67-72	aquaporin 4	Mus musculus	10-14
16551622-6	2006	TEA inhibition was lost upon a Tyr to Phe amino acid switch in the external water pore of AQP1/AQP2/AQP4, whereas the water permeability of AQP3 and AQP5, which lack a corresponding Tyr, was not blocked by TEA.	Water	76-81	aquaporin 4	Homo sapiens	100-104
16511868-9	2006	These results suggest that AQP4, but not AQP1 or AQP9, may play an important role in water movement associated with the pathophysiology of edema after transient cerebral ischemia in the mouse.	Water	85-90	aquaporin 4	Mus musculus	27-31
16751588-3	2006	Here, for the first time, we have expressed and purified the intracellular region of the rat ClC-3 chloride channel (C-ClC-3) as a water-soluble protein under physiological conditions, and investigated its structural characteristics and assembly behavior by means of circular dichroism (CD) spectroscopy, differential scanning calorimetry (DSC), size exclusion chromatography and analytical ultracentrifugation.	Water	131-136	chloride voltage-gated channel 3	Rattus norvegicus	93-98
16751588-3	2006	Here, for the first time, we have expressed and purified the intracellular region of the rat ClC-3 chloride channel (C-ClC-3) as a water-soluble protein under physiological conditions, and investigated its structural characteristics and assembly behavior by means of circular dichroism (CD) spectroscopy, differential scanning calorimetry (DSC), size exclusion chromatography and analytical ultracentrifugation.	Water	131-136	chloride voltage-gated channel 3	Rattus norvegicus	119-124
16627880-9	2006	The expression of AQP4, a water channel molecule, in the astrocyte end-feet was not significantly different between premature and mature infants, suggesting similar risk of brain edema in preterm and term infants in pathologic conditions.	Water	26-31	aquaporin 4	Homo sapiens	18-22
16608325-2	2006	The syn-oriented 2-OH takes over the catalytic role of the external water or amine molecule previously observed in 2-deoxy ester aminolysis.	Water	68-73	synemin	Homo sapiens	4-7
16470808-0	2006	Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels.	Water	85-90	aquaporin 4	Mus musculus	73-84
16470808-1	2006	The glial water channel aquaporin-4 (AQP4) has been hypothesized to modulate water and potassium fluxes associated with neuronal activity.	Water	10-15	aquaporin 4	Mus musculus	24-35
16470808-1	2006	The glial water channel aquaporin-4 (AQP4) has been hypothesized to modulate water and potassium fluxes associated with neuronal activity.	Water	10-15	aquaporin 4	Mus musculus	37-41
16470808-1	2006	The glial water channel aquaporin-4 (AQP4) has been hypothesized to modulate water and potassium fluxes associated with neuronal activity.	Water	77-82	aquaporin 4	Mus musculus	24-35
16470808-1	2006	The glial water channel aquaporin-4 (AQP4) has been hypothesized to modulate water and potassium fluxes associated with neuronal activity.	Water	77-82	aquaporin 4	Mus musculus	37-41
16364461-0	2006	Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice.	Water	33-38	neuropeptide Y receptor Y4	Mus musculus	71-82
16364461-5	2006	However, during the dark phase Y2 and Y4 receptor knockout mice drank significantly more (46-63%, P&lt;0.05) water than the control mice.	Water	109-114	neuropeptide Y receptor Y4	Mus musculus	38-49
16364461-9	2006	While beta-adrenoceptors and angiotensin AT1 receptors do not seem to be involved, water intake in Y2 and Y4 receptor knockout mice may be enhanced because presynaptic autoinhibition of NPY release and inhibition of orexin neurons in the central nervous system are prevented.	Water	83-88	neuropeptide Y receptor Y4	Mus musculus	106-117
16307881-5	2006	Compounds selected on the basis of SAR analysis of a novel lead compound showed acceptable early absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles and sufficient water solubility for use as infusion drugs.	Water	191-196	sarcosine dehydrogenase	Homo sapiens	35-38
16309912-2	2006	We synthesized 4-aminopiperidine derivatives of our prototype integrin alpha(v)beta3 antagonist 1 in an attempt to increase the activity and water solubility.	Water	141-146	integrin subunit alpha V	Homo sapiens	62-84
16416151-10	2006	We conclude that long-term water submersion has endocrine as well as plasma volume effects that are opposite to those seen after short-term immersion, and which increases plasma adrenomedullin.	Water	27-32	adrenomedullin	Homo sapiens	178-192
16553841-3	2006	Oocytes expressing these AQY1 alleles individually exhibited increased water permeability vs. water-injected oocytes, whereas oocytes expressing the AQY2 allele from UCD 932 did not show an increase, as expected, owing to an 11 bp deletion.	Water	71-76	Aqy1p	Saccharomyces cerevisiae S288C	25-29
16553841-3	2006	Oocytes expressing these AQY1 alleles individually exhibited increased water permeability vs. water-injected oocytes, whereas oocytes expressing the AQY2 allele from UCD 932 did not show an increase, as expected, owing to an 11 bp deletion.	Water	94-99	Aqy1p	Saccharomyces cerevisiae S288C	25-29
16521095-1	2006	Conventional diffusion tensor imaging (DTI) measures water diffusion parameters based on the assumption that the spin displacement distribution is a Gaussian function.	Water	53-58	spindlin 1	Homo sapiens	113-117
16539432-0	2006	Heats of transfer in the diffusion layer before the surface and the surface temperature for a catalytic hydrogen oxidation (H2 + (1/2)O2 --&gt; H2O) reaction.	Water	144-147	immunoglobulin kappa variable 1D-39	Homo sapiens	129-136
16315141-4	2006	The secondary structure consists of an alpha-helix for residues Arg2 to Arg20 in TFE/H2O solution and an alpha-helix for residues Arg2 to Ala17 in SDS solution.	Water	85-88	arginase 2	Homo sapiens	72-76
16570696-3	2006	Heat shock protein expression measured by immunoblot demonstrated that HSP25 was increased in the stomach, aorta and kidney of mice chronically fed acid water (8 weeks) compared to tap water fed controls.	Water	153-158	heat shock protein 1	Mus musculus	71-76
16570696-3	2006	Heat shock protein expression measured by immunoblot demonstrated that HSP25 was increased in the stomach, aorta and kidney of mice chronically fed acid water (8 weeks) compared to tap water fed controls.	Water	185-190	heat shock protein 1	Mus musculus	71-76
16570696-4	2006	HSP72 expression was also increased in the aorta of mice drinking acid water.	Water	71-76	heat shock protein 1A	Mus musculus	0-5
16410790-12	2006	Indeed, increased trans-epidermal water loss and permeability of Lucifer yellow were observed in DHCR24-/- mice.	Water	34-39	24-dehydrocholesterol reductase	Mus musculus	97-103
16432757-9	2006	The CPAP machine used for titration could produce highest pressure at 20 cm H2O.	Water	76-79	centromere protein J	Homo sapiens	4-8
16432757-12	2006	All of the untreated OSAHS patients could tolerate 17-20 cm H2O of CPAP during sleep.	Water	60-63	centromere protein J	Homo sapiens	67-71
16464697-1	2006	A previous pioneering study of freshwater bodies in Sri Lanka revealed the presence of toxic cyanobacteria in three out of four water bodies tested.	Water	36-41	sorcin	Homo sapiens	52-55
16629272-2	2006	In batch desorption tests, 3% of the adsorbed RDX (initially 71.1 mg RDX/g GAC) was desorbed by water over 11 days, compared to 92.6% desorption by 100% ethanol.	Water	96-101	radixin	Homo sapiens	46-49
16629272-3	2006	Solutions of ethanol or methanol in water also effectively desorbed RDX, although methanol was somewhat less effective than ethanol.	Water	36-41	radixin	Homo sapiens	68-71
16542568-4	2006	The secondary structure of lipoxygenase at the hexane-water interface was comparable to that of the structure of lipoxygenase in D(2)O after exposure of lipoxygenase solution to hexane.	Water	54-59	linoleate 9S-lipoxygenase-4	Glycine max	27-39
16516540-5	2006	A novel water-soluble metabolite, identified as 26-carboxy-1alpha,24(OH)2D2, was the presumed terminal degradation product of 1alpha(OH)D2 synthesized by CYP24A1 via successive 24-hydroxylation, 26-hydroxylation and further oxidation at C-26.	Water	8-13	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	154-161
16467332-6	2006	Expression of NOD2, IFN-beta, and IL-12p40 was higher with LF administration than with water or BSA administration.	Water	87-92	interleukin 12b	Mus musculus	34-42
16451748-3	2006	The water-soluble 46-kDa chitosan was the most effective at inhibiting pancreatic lipase activity (in-vitro) and plasma triacylglycerol elevation after the oral lipid tolerance test.	Water	4-9	pancreatic lipase	Mus musculus	71-88
16412116-4	2006	The level of AQP-5 expression was substantially reduced in animals with long-term anhidrosis, hence implicating water channel impairment as a possible factor in the development of this disorder.	Water	112-117	aquaporin-5	Equus caballus	13-18
16325200-1	2006	Aquaporin-4 (AQP4) is the predominant water channel in the mammalian brain and an important drug target for treatment of cerebral edema, bipolar disorder and mesial temporal lobe epilepsy.	Water	38-43	aquaporin 4	Homo sapiens	0-11
16325200-1	2006	Aquaporin-4 (AQP4) is the predominant water channel in the mammalian brain and an important drug target for treatment of cerebral edema, bipolar disorder and mesial temporal lobe epilepsy.	Water	38-43	aquaporin 4	Homo sapiens	13-17
16405352-7	2006	Calculation of the reaction path for the enzymatic hydrolysis of the substrate by dUTPase for an active-site model with 85 atoms, including several loosely bound water molecules, indicates that the method is feasible for the study of enzyme mechanisms.	Water	162-167	Deoxyuridine triphosphatase	Drosophila melanogaster	82-89
16206160-6	2006	The water channel aquaporin-4 (AQP4) also appears to be important for [K+]o buffering and is expressed in Muller cells in a very similar subcellular distribution pattern to that of Kir4.1.	Water	4-9	aquaporin 4	Homo sapiens	31-35
17090492-1	2006	The present work mainly deals with photocatalytic degradation of a herbicide, erioglaucine, in water in the presence of TiO2 nanoparticles (Degussa P-25) under ultraviolet (UV) light illumination (30 W).	Water	95-100	tubulin polymerization promoting protein	Homo sapiens	148-152
17135161-2	2006	Tyrosinase-inhibiting material was extracted with solvents methanol, acetone, ethanol, dimethyl sulphoxide in water, and with water only.	Water	110-115	tyrosinase	Homo sapiens	0-10
17135161-2	2006	Tyrosinase-inhibiting material was extracted with solvents methanol, acetone, ethanol, dimethyl sulphoxide in water, and with water only.	Water	126-131	tyrosinase	Homo sapiens	0-10
16399605-5	2006	Short- and long-term tap water alternatives are suggested for when tap water is deemed unsuitable for use.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
16399605-5	2006	Short- and long-term tap water alternatives are suggested for when tap water is deemed unsuitable for use.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	67-70
16399605-5	2006	Short- and long-term tap water alternatives are suggested for when tap water is deemed unsuitable for use.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	21-24
16399605-5	2006	Short- and long-term tap water alternatives are suggested for when tap water is deemed unsuitable for use.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
16408120-7	2006	Water restriction significantly (P&lt;0.05) increased the abundance of Na-K-2Cl cotransporter (NKCC2) and Na-Cl cotransporter (NCC) across ages.	Water	0-5	solute carrier family 12 member 1	Rattus norvegicus	95-100
16714844-0	2006	A legionellosis case due to contaminated spa water and confirmed by genomic identification in Taiwan.	Water	45-50	surfactant protein A2	Homo sapiens	41-44
16150492-6	2006	Sulfite oxidase deficiency was established by feeding rats a low molybdenum diet and adding to their drinking water 200 ppm tungsten (W).	Water	110-115	sulfite oxidase	Rattus norvegicus	0-15
16304088-5	2006	For MR colonography, the colon was filled with approximately 2000 mL of tap water.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
17176650-8	2006	Fluoridated tap water was associated with an overall improved profile of caries, concurrent with an expressively larger inequality in the distribution of dental disease.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
16548175-9	2006	And the positive correlation between GFAP-positive cell numbers and brain water content were shown by linear regression.	Water	74-79	glial fibrillary acidic protein	Rattus norvegicus	37-41
16325466-3	2005	Results indicate that human HSL, together with other lipolytic carboxylesterases, are active on short chain esters and hydrolyze water insoluble trioctanoin, vinyl laurate and olive oil, whereas the action of EST2, AFEST, protein RV1399C and non-lipolytic carboxylesterases is restricted to solutions of short chain substrates.	Water	129-134	lipase E, hormone sensitive type	Homo sapiens	28-31
18970321-9	2005	The developed method has been effectively applied to tap water and mineral water samples, with recoveries ranging from 90 to 102% for 5-ml samples passed through the two columns.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
16263905-7	2005	Water-soluble pectins were less methyl-esterified in qua1-1 than in wt.	Water	0-5	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	53-57
16405182-1	2005	A method for determining the earthy and musty odors 2-methylisoborneol (2-MIB) and geosmin in drinking water using static headspace-GC-MS is described.	Water	103-108	MIB E3 ubiquitin protein ligase 1	Homo sapiens	74-77
16376180-1	2005	A fast spin echo two-point Dixon (fast 2PD) technique was developed for efficient T2-weighted imaging with uniform water and fat separation.	Water	115-120	spindlin 1	Homo sapiens	7-11
16211562-3	2005	Aquaporin-4 (AQP4) water channel is expressed at high levels in brain astrocytes, and the bidirectional transport of water through these channels is critical for the maintenance of brain water homeostasis.	Water	19-24	aquaporin 4	Homo sapiens	0-11
16211562-3	2005	Aquaporin-4 (AQP4) water channel is expressed at high levels in brain astrocytes, and the bidirectional transport of water through these channels is critical for the maintenance of brain water homeostasis.	Water	19-24	aquaporin 4	Homo sapiens	13-17
16211562-3	2005	Aquaporin-4 (AQP4) water channel is expressed at high levels in brain astrocytes, and the bidirectional transport of water through these channels is critical for the maintenance of brain water homeostasis.	Water	117-122	aquaporin 4	Homo sapiens	0-11
16211562-3	2005	Aquaporin-4 (AQP4) water channel is expressed at high levels in brain astrocytes, and the bidirectional transport of water through these channels is critical for the maintenance of brain water homeostasis.	Water	117-122	aquaporin 4	Homo sapiens	13-17
16211562-6	2005	These increases in AQP4 levels were accompanied by a significant reduction in brain edema (assessed by percentage water content) at 3 days postinjury.	Water	114-119	aquaporin 4	Homo sapiens	19-23
16211562-7	2005	These findings suggest that the reduction of brain edema in response to SUL administration could be due, in part, to water clearance by AQP4 from the injured brain.	Water	117-122	aquaporin 4	Homo sapiens	136-140
16237719-1	2005	Aquaporin-4 (AQP4), a predominant water channel of the brain, mediates transmembrane water movement at the blood-brain barrier and brain-cerebrospinal fluid interface.	Water	34-39	aquaporin 4	Mus musculus	0-11
16237719-1	2005	Aquaporin-4 (AQP4), a predominant water channel of the brain, mediates transmembrane water movement at the blood-brain barrier and brain-cerebrospinal fluid interface.	Water	34-39	aquaporin 4	Mus musculus	13-17
16237719-1	2005	Aquaporin-4 (AQP4), a predominant water channel of the brain, mediates transmembrane water movement at the blood-brain barrier and brain-cerebrospinal fluid interface.	Water	85-90	aquaporin 4	Mus musculus	0-11
16237719-1	2005	Aquaporin-4 (AQP4), a predominant water channel of the brain, mediates transmembrane water movement at the blood-brain barrier and brain-cerebrospinal fluid interface.	Water	85-90	aquaporin 4	Mus musculus	13-17
16272281-6	2005	Surprisingly, TLR2-/-, TLR4-/-, and TLR9-/- mice were fully susceptible to EAU and had unaltered adaptive responses to interphotoreceptor retinoid-binding protein.	Water	75-78	toll-like receptor 9	Mus musculus	36-40
16092144-4	2005	Compounds 3 and 4 are isostructural and feature one-dimensional structures formed from the interconnection of [M2(cfH)2(H2O)2] dimers with bptc ligands.	Water	120-123	complement factor H	Homo sapiens	114-117
16283722-6	2005	These calculations explain how the replacement of just a few percent of beta-lactoglobulin by casein can inhibit the heat-induced thickening and flocculation behavior observed experimentally with some whey protein-stabilized oil-in-water emulsions.	Water	232-237	beta-lactoglobulin	Bos taurus	72-90
16395226-4	2005	Detachment of the RPE is likely to be a consequence of increased resistance of Bruch"s membrane to water flow due to deposition of lipids.	Water	99-104	ribulose-5-phosphate-3-epimerase	Homo sapiens	18-21
16381148-1	2005	Sales of bottled water have increased dramatically in recent years, with worldwide sales of more than dollars 35 billion, largely because of the public perception of purity and safety and public concern about the quality of tap water.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	224-227
16186376-1	2005	PURPOSE: In adult retina, aquaporin-4 (AQP4) and inwardly rectifying K(+) (Kir4.1) channels localize to astrocyte and Muller cell membranes facing vascular and vitreous compartments, optimizing clearance of extracellular K(+) and water from the synaptic layers.	Water	230-235	aquaporin 4	Mus musculus	26-37
16186376-1	2005	PURPOSE: In adult retina, aquaporin-4 (AQP4) and inwardly rectifying K(+) (Kir4.1) channels localize to astrocyte and Muller cell membranes facing vascular and vitreous compartments, optimizing clearance of extracellular K(+) and water from the synaptic layers.	Water	230-235	aquaporin 4	Mus musculus	39-43
16186376-12	2005	The transitory coexpression of AQP4 and Kir4.1 proteins by differentiating horizontal interneurons suggests that these cells mediate K(+) and water transcellular uptake until the initiation of phototransduction, when glial cells assume these functions.	Water	142-147	aquaporin 4	Mus musculus	31-35
16186821-2	2005	To understand this process, we examined interactions between Sec61alpha and all six TMs of the aquaporin-4 (AQP4) water channel at defined stages of synthesis using incorporated photo-cross-linking probes.	Water	114-119	SEC61 translocon subunit alpha 1	Homo sapiens	61-71
16186821-2	2005	To understand this process, we examined interactions between Sec61alpha and all six TMs of the aquaporin-4 (AQP4) water channel at defined stages of synthesis using incorporated photo-cross-linking probes.	Water	114-119	aquaporin 4	Homo sapiens	95-106
16186821-2	2005	To understand this process, we examined interactions between Sec61alpha and all six TMs of the aquaporin-4 (AQP4) water channel at defined stages of synthesis using incorporated photo-cross-linking probes.	Water	114-119	aquaporin 4	Homo sapiens	108-112
16131464-2	2005	First, the adsorption of 2-methylisoborneol (2-MIB) on USY in a river water/pure water mixture was clarified by a batch-type adsorption experiment.	Water	70-75	MIB E3 ubiquitin protein ligase 1	Homo sapiens	47-50
16131464-2	2005	First, the adsorption of 2-methylisoborneol (2-MIB) on USY in a river water/pure water mixture was clarified by a batch-type adsorption experiment.	Water	81-86	MIB E3 ubiquitin protein ligase 1	Homo sapiens	47-50
16131464-4	2005	The desorption rate was increased with the ratio of river water to pure water, indicating that compounds dissolved in the river water, such as natural organic matter (NOM), prevent the adsorption of 2-MIB on USY.	Water	58-63	MIB E3 ubiquitin protein ligase 1	Homo sapiens	201-204
16131464-4	2005	The desorption rate was increased with the ratio of river water to pure water, indicating that compounds dissolved in the river water, such as natural organic matter (NOM), prevent the adsorption of 2-MIB on USY.	Water	72-77	MIB E3 ubiquitin protein ligase 1	Homo sapiens	201-204
16131464-4	2005	The desorption rate was increased with the ratio of river water to pure water, indicating that compounds dissolved in the river water, such as natural organic matter (NOM), prevent the adsorption of 2-MIB on USY.	Water	72-77	MIB E3 ubiquitin protein ligase 1	Homo sapiens	201-204
16131464-9	2005	We therefore performed a trial in which 2-MIB dissolved in river water was continuously decomposed using a USY-packed column with various ozone concentrations.	Water	65-70	MIB E3 ubiquitin protein ligase 1	Homo sapiens	42-45
16201439-1	2005	When viewed from the stern, a ship"s turbulent wake appears as a narrow strip of bubble-whitened water converging toward the horizon.	Water	97-102	inositol polyphosphate-5-phosphatase D	Homo sapiens	30-34
16134088-8	2005	Among the new synthesized copolymers (P1-P23), seven diblock or triblock samples (P3, P6, P7, P11, P12, P19, and P21) with higher hydrophilic building block populations were revealed to be water soluble under ambient temperature.	Water	189-194	exosome component 6	Homo sapiens	94-97
16128692-9	2005	Both total tissue water (TTW) and extravasation of albumin, measured as the plasma-to-tissue clearance (E-alb) showed a significant increase after PAF (n = 7, P &lt; 0.05).	Water	18-23	PCNA clamp associated factor	Rattus norvegicus	147-150
16128692-11	2005	It also increases transcapillary fluid flux, and lowers P(if), indicating a role for PAF in the interstitium for generation of transcapillary transport of water and large molecules followed by formation of oedema.	Water	155-160	PCNA clamp associated factor	Rattus norvegicus	85-88
16076766-11	2005	The water extracts of adlay seeds also enhanced extracellular signal-regulated protein kinase (ERK) 1/2 phosphorylation and protein kinase C (PKC)-alpha translocation from cytosolic to particulate fractions in uteri.	Water	4-9	protein kinase C, alpha	Rattus norvegicus	124-152
15906101-6	2005	The implications of enhanced symplastic water transport via NtAQP1 for the efficiency of the AM symbiosis under drought stress conditions are further discussed.	Water	40-45	probable aquaporin TIP1-1	Nicotiana tabacum	60-66
16087714-0	2005	IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.	Water	71-76	aquaporin 4	Homo sapiens	59-70
16087714-4	2005	Here we show that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier.	Water	63-68	aquaporin 4	Homo sapiens	51-62
16122167-7	2005	The method has been used to determine heavy metal ions in tap water.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
16097805-18	2005	Similarly, decomposition of P9 led to the formation of P4-2, P6, and nucleoside products resulting from opening of the oxirane ring by dihydrogen phosphate ion, water, or chloride ion.	Water	161-166	erythrocyte membrane protein band 4.2	Homo sapiens	55-59
16152968-9	2005	Accumulation of RDX in fish that were fed oligochaetes exposed to an exceedingly high water concentration of RDX was minimal.	Water	86-91	radixin	Ictalurus punctatus	16-19
15953563-0	2005	Suppressive effect of AIF, a water extract from three herbs, on collagen-induced arthritis in mice.	Water	29-34	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	22-25
16392774-3	2005	L-NAME treatment (0.7 mg/ml in drinking water) significantly decreased the gene and protein expression of endothelial nitric oxide synthase (eNOS) and increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, vascular cell adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1) mRNA levels in the aorta, as determined by Western blotting and reverse transcription (RT)-polymerase chain reaction (PCR).	Water	40-45	nitric oxide synthase 3	Rattus norvegicus	106-139
16392774-3	2005	L-NAME treatment (0.7 mg/ml in drinking water) significantly decreased the gene and protein expression of endothelial nitric oxide synthase (eNOS) and increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, vascular cell adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1) mRNA levels in the aorta, as determined by Western blotting and reverse transcription (RT)-polymerase chain reaction (PCR).	Water	40-45	nitric oxide synthase 3	Rattus norvegicus	141-145
15976003-13	2005	In summary, these findings demonstrate that the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the HPS/aBS model.	Water	186-191	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	122-125
16095377-2	2005	All studied water models show multiple liquid-liquid phase transitions in the supercooled region: we observe two transitions of the TIP4P, TIP5P, and SPCE models and three transitions of the ST2 model.	Water	12-17	ST2	Homo sapiens	191-194
15883986-1	2005	A kinetic study was carried out on the aminolysis of p-nitrophenyl acetate (NPA) by n-decylamine (DEC), piperazine (PIP) and sarcosine (SAR) in AOT/isooctane/water (w/o) microemulsions.	Water	158-163	sarcosine dehydrogenase	Homo sapiens	136-139
15989334-3	2005	This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.	Water	100-105	5-hydroxytryptamine receptor 1D	Homo sapiens	223-229
15741609-10	2005	Oocytes expressing mouse urea transporter A3 (UT-A3) exhibited 7.5-fold faster phloretin-inhibitable urea transport compared with water-injected controls.	Water	130-135	solute carrier family 14 (urea transporter), member 2	Mus musculus	25-44
15741609-10	2005	Oocytes expressing mouse urea transporter A3 (UT-A3) exhibited 7.5-fold faster phloretin-inhibitable urea transport compared with water-injected controls.	Water	130-135	solute carrier family 14 (urea transporter), member 2	Mus musculus	46-51
15966864-4	2005	Whereas Aqy1 is a spore-specific water channel, Aqy2 is only expressed in proliferating cells and controlled by osmotic signals.	Water	33-38	Aqy1p	Saccharomyces cerevisiae S288C	8-12
21432136-1	2005	Bathing in water (balneotherapy or spa therapy) has been frequently and widely used in classical medicine as a cure for diseases.	Water	11-16	surfactant protein A2	Homo sapiens	35-38
15899256-7	2005	In a second experiment, the effect of water availability on FosB staining 8 h after injections of 6% NaCl was tested in 3 groups of rats: water ad libitum, rats that had no access to water, and rats that were given water 2 h prior to perfusion.	Water	38-43	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	60-64
15899256-8	2005	FosB staining was significantly reduced in both the SON and the PVN of rats that had ad libitum water compared to the two water-restricted groups.	Water	96-101	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-4
15899256-8	2005	FosB staining was significantly reduced in both the SON and the PVN of rats that had ad libitum water compared to the two water-restricted groups.	Water	122-127	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-4
15899256-11	2005	FosB staining was significantly increased at 24 h in the rats injected with 6% NaCl when water was restricted.	Water	89-94	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-4
16149302-0	2005	[Impact of iodination on the total mutagenic activity of chlorinated tap water].	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
16149302-1	2005	The impact of iodination on the total mutagenic activity (TMA) of chlorinated tap water was studied.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
16149302-5	2005	Iodination substantially reduced the TMA of chlorinated tap water.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
16149302-6	2005	The minimally effective dose of iodine against the TMA of chlorinated tap water was 1 mg/l, as evidenced by the tests using all the strains/variants and 0.5 mg/l, as shown by the tests using the strain TA 100 in the variant without metabolic activation.	Water	74-79	nuclear RNA export factor 1	Homo sapiens	70-73
15921925-4	2005	In the negative ion mode, the fluorobutyl methyl ether undergoes dissociative electron capture with O2-*, O2-*(H2O), O3-*, and NO2- to generate the fluorobutoxy anion, which can dissociate by CF2[doublebond]O loss to give the perfluorocarbanion when the precursor ions are internally excited.	Water	111-114	immunoglobulin kappa variable 1D-39	Homo sapiens	106-110
15914151-4	2005	We show that AP-1 is very stable at the air-water interface and suggest that AP-1 may not be substantially formed in solution as a stable equimolar association of both proteins.	Water	44-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-17
16024389-5	2005	The per-ship inoculation size from ballast water depends upon both the volume discharged and the organism density.	Water	43-48	inositol polyphosphate-5-phosphatase D	Homo sapiens	8-12
15922052-4	2005	Learning and memory assessment using a 3-day water maze protocol demonstrated that aged Pdyn knockout mice (13-17 months) perform comparatively better than similarly aged wild-type (WT) mice, based on acquisition and retention probe trial indices.	Water	45-50	prodynorphin	Mus musculus	88-92
15621250-3	2005	In this study, synthetic glucagon-like peptide-1 (GLP-1) (7-37) was conjugated to a water-soluble polymer, poly(N-vinyl-2-pyrroridone-co-acrylic acid) (5 mol% acrylic acid, M(w) 445 kDa), via poly(ethylene glycol, M(w) 3.4 kDa) spacer.	Water	84-89	glucagon	Rattus norvegicus	25-48
15621250-3	2005	In this study, synthetic glucagon-like peptide-1 (GLP-1) (7-37) was conjugated to a water-soluble polymer, poly(N-vinyl-2-pyrroridone-co-acrylic acid) (5 mol% acrylic acid, M(w) 445 kDa), via poly(ethylene glycol, M(w) 3.4 kDa) spacer.	Water	84-89	glucagon	Rattus norvegicus	50-55
15846795-5	2005	Furthermore, passive K+ uptake mechanisms and water flux mediated through aquaporin-4 channels in endfoot processes are important energy-independent mechanisms.	Water	46-51	aquaporin 4	Homo sapiens	74-85
15902435-9	2005	The incidence of EAU was 40.0% in WT mice, 59.3% in GRKO mice and 78.6% in fyn KO mice.	Water	17-20	Fyn proto-oncogene	Mus musculus	75-78
15902435-11	2005	Upon EAU induction, significant infiltration of eosinophils into the eyes was observed in GRKO and fyn KO mice compared to WT mice.	Water	5-8	Fyn proto-oncogene	Mus musculus	99-102
15914623-4	2005	METHODS: EAU was induced either by immunizing B10.RIII mice with the 161-180 peptide or by adoptive transfer of interphotoreceptor retinoid-binding protein (IRBP)-specific uveitogenic T cells.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	112-155
15914623-4	2005	METHODS: EAU was induced either by immunizing B10.RIII mice with the 161-180 peptide or by adoptive transfer of interphotoreceptor retinoid-binding protein (IRBP)-specific uveitogenic T cells.	Water	9-12	retinol binding protein 3, interstitial	Mus musculus	157-161
15866015-5	2005	by the use of disposable, terminal tap water filter systems with non-impregnated, as well as impregnated, filters with prolonged usage intervals.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
16046831-4	2005	We used tap water to wash the hands at the sink used for washing surgical instruments in the operating room and non sterilized plastic brushes.	Water	12-17	nuclear RNA export factor 1	Homo sapiens	8-11
16046831-9	2005	When using tap water for surgical hand washing, 1) the hand-rubbing method should be used; 2) a quick-alcohol-based disinfectant scrub should be used; 3) the concentration of free chloride in the water should be maintained at over 0.1 PPM; 4) the bacterial contamination of the water should be checked; and 5) the faucet should be routinely cleaned and sterilized.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
15951638-8	2005	Water storage tanks appear to promote FLA colonization, including Acanthamoeba, in domestic tap water.	Water	0-5	nuclear RNA export factor 1	Homo sapiens	92-95
16049787-5	2005	Both WT and C28A, C51A MSP aggregate upon heating, but an examination of the effects of protein concentration and pH on heat-induced aggregation showed that each MSP species exhibited greater resistance to aggregation at a pH near their pI (5.2) than do either bovine serum albumin (BSA) or carbonic anhydrase, which were used as model water soluble proteins.	Water	336-341	microseminoprotein beta	Homo sapiens	162-165
16008972-10	2005	All of the untreated OSAHS patients could tolerate 17-20 cm H2O of CPAP during NREM and REM sleep.	Water	60-63	centromere protein J	Homo sapiens	67-71
15651982-2	2005	Similar to these already known substrates of SMCT, the water-soluble B-complex vitamin nicotinic acid also exists as a monocarboxylate anion (nicotinate) under physiological conditions.	Water	55-60	solute carrier family 5 member 8	Homo sapiens	45-49
15651982-15	2005	We conclude that SMCT functions not only as a Na+-coupled transporter for short-chain fatty acids and lactate but also as a Na+-coupled transporter for the water-soluble vitamin nicotinic acid.	Water	156-161	solute carrier family 5 member 8	Homo sapiens	17-21
15876016-2	2005	Treatment of Boc-terminated pendant groups on the optically active units with 3 M HCl in dioxane yields cationic water-soluble dendrimers.	Water	113-118	BOC cell adhesion associated, oncogene regulated	Homo sapiens	13-16
15890005-6	2005	c-Abl and Arg nonreceptor protein tyrosine kinases associate with catalase in cells treated with H(2)O(2) by mechanisms involving the SH3 domains of the kinases and the Pro(293)PheAsnPro motif of catalase and activate catalase by phosphorylating it on Tyr(231) and Tyr(386).	Water	97-102	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-5
15885091-5	2005	Establishing by electrochemical methods the endogenous production H(2)O(2) in real time confirms recent reports, based in large part on the use of exogenous H(2)O(2), that tyrosinase can manifest both catalase and peroxidase activities.	Water	66-71	tyrosinase	Homo sapiens	172-182
15981579-0	2005	[Carbonic anhydrase B interactions with water and urea].	Water	40-45	carbonic anhydrase 2	Homo sapiens	1-21
15875321-15	2005	The vasodilator effects of the peroxynitrite and H(2)O(2)0 generated from the NO metabolism are what enhance the functional role of the nNOS-derived NO release in the orchidectomized rats.	Water	49-54	nitric oxide synthase 1	Rattus norvegicus	136-140
15705590-7	2005	This study is the first demonstration that PLD2 activation is implicated in Src-dependent phosphorylation of Pyk2 (Tyr(580) and Tyr(881)) by promoting the complex formation between Pyk2 and activated Src in PC12 cells exposed to H(2)O(2), thereby resulting in activation of the survival signaling pathway PI3K/Akt/p70S6K.	Water	229-234	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	76-79
16851857-2	2005	Comparison of the vacuum and solution free energy surfaces for maltose shows the principal effects of water to be an increase in the rotational freedom of the alpha(1 --&gt; 4) linkage brought about by lowering the energy barrier for syn to anti conformational changes as well as expansion of the range of low-energy phi,psi conformations.	Water	102-107	synemin	Homo sapiens	234-237
15765520-2	2005	The water channel aquaporin-4 (AQP4) has been found to be an important determinant of brain water accumulation and clearance of excess brain water.	Water	4-9	aquaporin 4	Mus musculus	31-35
15765520-2	2005	The water channel aquaporin-4 (AQP4) has been found to be an important determinant of brain water accumulation and clearance of excess brain water.	Water	92-97	aquaporin 4	Mus musculus	31-35
15765520-7	2005	Acute water intoxication (intraperitoneal water, 20% body weight) produced a gradual increase in DeltaI/Io of 12 +/- 4% in wild-type mice at 5 min, much greater than that of 2 +/- 1% in AQP4-null mice.	Water	6-11	aquaporin 4	Mus musculus	186-190
15795759-1	2005	Single crystal X-ray diffraction studies on the water soluble, synthetic tetrapeptide Tyr(1)-Aib(2)-Tyr(3)-Val(4) with a non-coded amino acid residue (Aib: [small alpha]-amino isobutyric acid) reveal that the peptide adopts an "S"-shaped molecular structure which self-assembles to form a supramolecular triple helix using various non-covalent interactions including water mediated hydrogen bonds in the solid state.	Water	48-53	ANIB1	Homo sapiens	93-96
15795759-1	2005	Single crystal X-ray diffraction studies on the water soluble, synthetic tetrapeptide Tyr(1)-Aib(2)-Tyr(3)-Val(4) with a non-coded amino acid residue (Aib: [small alpha]-amino isobutyric acid) reveal that the peptide adopts an "S"-shaped molecular structure which self-assembles to form a supramolecular triple helix using various non-covalent interactions including water mediated hydrogen bonds in the solid state.	Water	48-53	ANIB1	Homo sapiens	151-154
15699457-2	2005	We hypothesized that the metabolism of EETs by the sEH contributes to angiotensin II-induced hypertension and tested the effects of a water-soluble sEH inhibitor, 12-(3-adamantan-1-yl-ureido) dodecanoic acid (AUDA) on blood pressure.	Water	134-139	epoxide hydrolase 2, cytoplasmic	Mus musculus	148-151
15780095-7	2005	Water deprivation increased the number of HIF-1alpha-positive cells, which may be mediated by an increase in medullar workload and a decrease in local blood flow.	Water	0-5	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	42-52
15644319-5	2005	The role of O(2)(-) and related products such as H(2)O(2) in stimulating the expression of protein tyrosine kinase is suggested by the observation that addition of 50-200 microm H(2)O(2) increased the phosphorylation of c-Jun and the expression of c-Src in M1 cells, a mouse collecting duct principal cell line.	Water	49-54	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	248-253
15767727-6	2005	Pancreatic ductal cells are largely responsible for the amount of bicarbonate and water secretion in response to secretin stimulation.	Water	82-87	secretin	Homo sapiens	113-121
15746420-1	2005	We measured the angular rotation and proper motion of the Triangulum Galaxy (M33) with the Very Long Baseline Array by observing two H2O masers on opposite sides of the galaxy.	Water	133-136	chromobox 2	Homo sapiens	77-80
15732937-0	2005	Method for trace level analysis of C8, C9, C10, C11, and C13 perfluorocarbon carboxylic acids in water.	Water	97-102	RNA polymerase III subunit K	Homo sapiens	48-51
15732937-0	2005	Method for trace level analysis of C8, C9, C10, C11, and C13 perfluorocarbon carboxylic acids in water.	Water	97-102	homeobox C13	Homo sapiens	57-60
15732937-4	2005	The lower limit of quantitation (LLOQ) for C8, C9, C10, C11, and C13 was determined to be 25 ng/L in water.	Water	101-106	RNA polymerase III subunit K	Homo sapiens	56-59
15732937-4	2005	The lower limit of quantitation (LLOQ) for C8, C9, C10, C11, and C13 was determined to be 25 ng/L in water.	Water	101-106	homeobox C13	Homo sapiens	65-68
15737334-2	2005	Oocytes expressing hCAT-3 displayed less negative membrane potentials and larger voltage-dependent currents than native or water-injected oocytes did.	Water	123-128	solute carrier family 7 member 3	Homo sapiens	19-25
15756018-8	2005	Treatment of EGCG-rich GTP in drinking water to 4T1 cells bearing BALB/c mice resulted in reduction of tumor growth accompanied with increase in Bax/Bcl-2 ratio, reduction in proliferating cell nuclear antigen and activation of caspase 3 in tumors.	Water	39-44	BCL2-associated X protein	Mus musculus	145-148
15714242-6	2005	Patients performed antegrade enemas every 24 to 48 hours with tap water.	Water	66-71	nuclear RNA export factor 1	Homo sapiens	62-65
16013579-0	2005	[Determination of bromodichloromethane and dibromochloromethane in tap water using headspace gas chromatography with standard addition method].	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
15667298-4	2005	The other enzyme (NAP) is water-soluble and located in the periplasm.	Water	26-31	catenin beta like 1	Homo sapiens	18-21
15689218-7	2005	Bathing in the Dead Sea salt solution significantly improved skin barrier function compared with the tap water-treated control forearm in the subgroup with elevated basal TEWL.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
15684336-4	2005	ApoAI was also detected in water-extracted amyloid material by immunoblotting.	Water	27-32	apolipoprotein A-I	Mus musculus	0-5
15659378-0	2005	Reversible self-association of ovalbumin at air-water interfaces and the consequences for the exerted surface pressure.	Water	48-53	ovalbumin (SERPINB14)	Gallus gallus	31-40
15596131-1	2005	Aquaporin-5 (AQP5), a major water channel in lung epithelial cells, plays an important role in maintaining water homeostasis in the lungs.	Water	28-33	aquaporin 5	Mus musculus	0-11
15596131-1	2005	Aquaporin-5 (AQP5), a major water channel in lung epithelial cells, plays an important role in maintaining water homeostasis in the lungs.	Water	28-33	aquaporin 5	Mus musculus	13-17
15596131-1	2005	Aquaporin-5 (AQP5), a major water channel in lung epithelial cells, plays an important role in maintaining water homeostasis in the lungs.	Water	107-112	aquaporin 5	Mus musculus	0-11
15596131-1	2005	Aquaporin-5 (AQP5), a major water channel in lung epithelial cells, plays an important role in maintaining water homeostasis in the lungs.	Water	107-112	aquaporin 5	Mus musculus	13-17
15596131-7	2005	These findings demonstrate that LPS increases cell surface AQP5 expression by changing its subcellular distribution and increases membrane osmotic water permeability through activation of p38 MAP kinase.	Water	147-152	aquaporin 5	Mus musculus	59-63
15651975-0	2005	Throwing the baby out with the spa water?	Water	35-40	surfactant protein A2	Homo sapiens	31-34
15801046-0	2005	Throwing the baby out with the spa water?	Water	35-40	surfactant protein A2	Homo sapiens	31-34
15623296-6	2005	Tap water was analyzed, and lead emissions were clearly observed.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
16961003-6	2005	Further analysis of the data suggested that tap water concentrations primarily controlled the blood concentrations from bathing exposure, whereas tap water concentrations and ambient air concentrations resulting from water use affected the blood concentrations from showering exposure.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
16961003-6	2005	Further analysis of the data suggested that tap water concentrations primarily controlled the blood concentrations from bathing exposure, whereas tap water concentrations and ambient air concentrations resulting from water use affected the blood concentrations from showering exposure.	Water	150-155	nuclear RNA export factor 1	Homo sapiens	146-149
16961003-6	2005	Further analysis of the data suggested that tap water concentrations primarily controlled the blood concentrations from bathing exposure, whereas tap water concentrations and ambient air concentrations resulting from water use affected the blood concentrations from showering exposure.	Water	150-155	nuclear RNA export factor 1	Homo sapiens	146-149
15644082-9	2005	Even if cavitation intensity in glycerin solution was greater, the cavitation occurrence probability was less in glycerin solution than in tap water.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
15644082-10	2005	Our results suggest that tap water contains particles that cause an increase in the cavitation occurrence probability.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	25-28
16235508-17	2005	Removal of contact lenses and immediate irrigation with room temperature tap water is recommended for ocular exposures.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
15701379-3	2005	Furthermore, around 48% (123 samples) of the tap-water samples taken from 255 dwellings showed radon concentrations over the MCL.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
15637337-0	2005	Upregulation of neuronal nitric oxide synthase mRNA and protein in adrenal medulla of water-deprived rats.	Water	86-91	nitric oxide synthase 1	Rattus norvegicus	16-46
15637337-2	2005	Using an RT-PCR technique, the relative quantities of nNOS mRNA as well as the tyrosine hydroxylase and phenylethanolamine N-methyltransferase mRNA in the adrenals of water-deprived rats significantly increased from 12 hr to 4 days.	Water	167-172	nitric oxide synthase 1	Rattus norvegicus	54-58
15637337-3	2005	In situ hybridization and immunohistochemical study showed that water deprivation activated nNOS mRNA and protein expression in the adrenal medulla.	Water	64-69	nitric oxide synthase 1	Rattus norvegicus	92-96
15637337-4	2005	Four days after water deprivation, nNOS protein expression determined by Western blot significantly increased in the adrenal gland.	Water	16-21	nitric oxide synthase 1	Rattus norvegicus	35-39
15637337-5	2005	Our results are the first to demonstrate that nNOS syntheses in the adrenal medulla are markedly increased in water-deprived rats.	Water	110-115	nitric oxide synthase 1	Rattus norvegicus	46-50
15561740-2	2005	Average activity concentrations of 238U, 234U and 235U in tap water from surface water were 9.6 +/- 7.1, 12.8 +/- 9.7 and 0.41 +/- 0.31 Bq m(-3), respectively, whereas from ground water they were 4.5 +/- 6.0, 5.7 +/- 6.9 and 0.19 +/- 0.27 Bq m(-3), respectively.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
15561740-2	2005	Average activity concentrations of 238U, 234U and 235U in tap water from surface water were 9.6 +/- 7.1, 12.8 +/- 9.7 and 0.41 +/- 0.31 Bq m(-3), respectively, whereas from ground water they were 4.5 +/- 6.0, 5.7 +/- 6.9 and 0.19 +/- 0.27 Bq m(-3), respectively.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	58-61
15561740-2	2005	Average activity concentrations of 238U, 234U and 235U in tap water from surface water were 9.6 +/- 7.1, 12.8 +/- 9.7 and 0.41 +/- 0.31 Bq m(-3), respectively, whereas from ground water they were 4.5 +/- 6.0, 5.7 +/- 6.9 and 0.19 +/- 0.27 Bq m(-3), respectively.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	58-61
15730819-0	2004	[Expression of aquaporin-4 water channel in the MRI graphic-ischaemic penumbra].	Water	27-32	aquaporin 4	Homo sapiens	15-26
15517312-4	2004	The expression of aquaporin-4 (AQP-4), the predominant water channel in the brain, was studied with quantitative real time PCR analysis, light microscopic immunohistochemistry and high-resolution immunogold labeling.	Water	55-60	aquaporin 4	Homo sapiens	18-29
15517312-4	2004	The expression of aquaporin-4 (AQP-4), the predominant water channel in the brain, was studied with quantitative real time PCR analysis, light microscopic immunohistochemistry and high-resolution immunogold labeling.	Water	55-60	aquaporin 4	Homo sapiens	31-36
15558519-10	2004	Lack of uromodulin function(s) is associated with impairments in tubular function, particularly the urine-concentrating process, determining water depletion and hyperuricemia.	Water	141-146	uromodulin	Homo sapiens	8-18
15689033-5	2004	The pK2 for the ionization in water +10, +20, +30, +40, and +50 wt % dioxane has been determined at five different temperatures from 15 to 35 degrees C at intervals of 5 degrees C. The thermodynamic quantities were calculated.	Water	30-35	prokineticin 2	Homo sapiens	4-7
15567676-12	2004	In 95.2% of the departments the nebulizers were filled with tap water and were not changed on a daily basis (81.2%).	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
15582678-6	2004	O-PAL had a greater water intake than O-SHAM.	Water	20-25	leucine-rich repeat, Ig-like and transmembrane domains 1	Rattus norvegicus	2-5
15504348-3	2004	Intense SGK1 staining was observed in Purkinje cells following 48h of water deprivation.	Water	70-75	serum/glucocorticoid regulated kinase 1 L homeolog	Xenopus laevis	8-12
15197512-7	2004	If the energy cost of such water penetration is significant enough, this may be a factor in the enhanced dimerization affinity of Glu664-mutant Neu.	Water	27-32	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	144-147
15501249-2	2004	The transport pathways by which water and solutes cross the endothelium in response to VEGF, however, are not completely understood.	Water	32-37	vascular endothelial growth factor A	Bos taurus	87-91
15501249-5	2004	The sudden application of a 10-cm H2O hydrostatic pressure gradient induced water and solute fluxes that decayed to steady-state values after approximately 2 h. Subsequently, the addition of VEGF significantly increased Lp and Pe by 4.3-fold +/- 0.7-fold and 3.0-fold +/- 0.3-fold, respectively, after 110 min; however, the reflection coefficient remained approximately constant throughout the experiment (approximately 0.8).	Water	34-37	vascular endothelial growth factor A	Bos taurus	191-195
15501249-5	2004	The sudden application of a 10-cm H2O hydrostatic pressure gradient induced water and solute fluxes that decayed to steady-state values after approximately 2 h. Subsequently, the addition of VEGF significantly increased Lp and Pe by 4.3-fold +/- 0.7-fold and 3.0-fold +/- 0.3-fold, respectively, after 110 min; however, the reflection coefficient remained approximately constant throughout the experiment (approximately 0.8).	Water	76-81	vascular endothelial growth factor A	Bos taurus	191-195
15623335-5	2004	The most effective potentiation was observed with the water-soluble PP(Arg)2 and 5-MOP concentrations lower than 0.75 microM.	Water	54-59	arginase 2	Homo sapiens	71-76
15623335-11	2004	PPIX, which is barely soluble in water, has a significantly higher affinity for cell membranes and simultaneously exerts a stronger phototoxic effect than PP(Arg)2 whose solubility in water is high.	Water	184-189	arginase 2	Homo sapiens	158-163
15476806-0	2004	Thermodynamic signature of GCN4-bZIP binding to DNA indicates the role of water in discriminating between the AP-1 and ATF/CREB sites.	Water	74-79	cAMP responsive element binding protein 1	Homo sapiens	123-127
15482585-0	2004	Long-term suppression of methamphetamine-induced c-Fos expression in rat striatum by the injection of c-fos antisense oligodeoxynucleotides absorbed in water-absorbent polymer.	Water	152-157	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-54
15482585-0	2004	Long-term suppression of methamphetamine-induced c-Fos expression in rat striatum by the injection of c-fos antisense oligodeoxynucleotides absorbed in water-absorbent polymer.	Water	152-157	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	102-107
15371505-8	2004	In contrast to the slowed diffusion produced by brain edema and seizure activity, diffusion in the ECS was faster in mice lacking aquaporin-4 (AQP4), an astroglial water channel that facilitates fluid movement between cells and the ECS.	Water	164-169	aquaporin 4	Mus musculus	130-141
15371505-8	2004	In contrast to the slowed diffusion produced by brain edema and seizure activity, diffusion in the ECS was faster in mice lacking aquaporin-4 (AQP4), an astroglial water channel that facilitates fluid movement between cells and the ECS.	Water	164-169	aquaporin 4	Mus musculus	143-147
15356189-6	2004	Isolated mitochondrial alpha-ketoglutarate dehydrogenase (KGDHC) and pyruvate dehydrogenase (PDHC) complexes produced superoxide and H(2)O(2).	Water	133-138	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	Mus musculus	23-56
15333922-0	2004	Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B.	Water	0-5	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	58-89
15333922-2	2004	Detailed structural information about the structure of PTP1B, including the conformation and flexibility of active-site residues as well as the water-molecule network, is a key issue in understanding ligand binding and enzyme kinetics and in structure-based drug design.	Water	144-149	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	55-60
15333922-3	2004	A 1.95 A apo PTP1B structure has been obtained, showing four highly coordinated water molecules in the active-site pocket of the enzyme; hence, the active site is highly solvated in the apo state.	Water	80-85	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	13-18
15142833-5	2004	Fos-positive neurons were sparse in euhydrated rats but were numerous in the SFO, MnPO, and the dorsal cap of the OVLT after 48-h water deprivation.	Water	130-135	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
15300159-5	2004	Analysis of the UT-A1 promoter suggests that vasopressin increases UT-A1 indirectly following a direct effect to increase the transcription of other genes, such as the Na(+)-K(+)-2Cl- cotransporter NKCC2/BSC1 and the aquaporin (AQP) 2 water channel, that begin to increase inner medullary osmolality.	Water	235-240	solute carrier family 14 (urea transporter), member 2	Mus musculus	67-72
15380376-0	2004	Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake.	Water	87-92	cannabinoid receptor 1	Rattus norvegicus	36-39
15325157-2	2004	We investigated the mortality of a cohort of 5144 residents in Guastalla, northern Italy, who were supplied tap water with high chloroform and trihalomethane content between 1965 and 1987.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
15301762-0	2004	Aquaporin water channels AQP1 and AQP3, are expressed in equine articular chondrocytes.	Water	10-15	aquaporin 3	Equus caballus	34-38
15301762-10	2004	AQP1 and AQP3 may be involved in the transport of water and small solutes and osmotically active metabolites across the chondrocyte plasma membrane during volume regulatory behaviour.	Water	50-55	aquaporin 3	Equus caballus	9-13
15185393-0	2004	Laminin-induced aggregation of the inwardly rectifying potassium channel, Kir4.1, and the water-permeable channel, AQP4, via a dystroglycan-containing complex in astrocytes.	Water	90-95	aquaporin 4	Homo sapiens	115-119
15527074-1	2004	Treatment of human stomach cancer KATO III cells with hot-water extracts from adzuki beans led to their growth inhibition as well as apoptosis induction.	Water	58-63	alcohol dehydrogenase iron containing 1	Homo sapiens	54-57
15527074-6	2004	These results suggest that the fraction of hot-water adzuki extracts may serve as a nutrapharmaceutical or functional food available for cancer prevention.	Water	47-52	alcohol dehydrogenase iron containing 1	Homo sapiens	43-46
15275954-7	2004	In infralimbic cortex, rats, which learned the reward value of the olfactory cue and were water-reinforced the day of sacrifice, showed a higher Fos expression.	Water	90-95	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	145-148
15260473-4	2004	The possible existence of a lipid-water interface due to the formation of small aggregates of vinyl esters or TAG in solution may account for the HSL activity observed below the solubility limit of the substrate.	Water	34-39	lipase E, hormone sensitive type	Homo sapiens	146-149
15241470-7	2004	att1 has a loose cuticle membrane ultrastructure and shows increased permeability to water vapor, demonstrating the importance of the cuticle membrane in controlling water loss.	Water	85-90	cytochrome P450, family 86, subfamily A, polypeptide 2	Arabidopsis thaliana	0-4
15180924-5	2004	Complementary RNA from two amino acid transporters yielded l-DOPA uptake significantly above water-injected controls the rBAT/b(0,+)AT dimer (rBAT) and the LAT2/4F2 dimer (LAT2).	Water	93-98	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	121-125
15180924-5	2004	Complementary RNA from two amino acid transporters yielded l-DOPA uptake significantly above water-injected controls the rBAT/b(0,+)AT dimer (rBAT) and the LAT2/4F2 dimer (LAT2).	Water	93-98	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	142-146
15330391-4	2004	Participants with lead in the tap water above the detection limit of 5 microg/l (N = 142) showed significantly higher blood lead levels (median 31 microg/l) compared to those with no detectable lead in the tap water (N = 106; median blood lead 24 microg/l, p &lt; = 0.001).	Water	34-39	nuclear RNA export factor 1	Homo sapiens	30-33
15330391-5	2004	There is a close correlation between the average lead concentration in the tap water and blood lead concentrations (N = 142 value pairs, Spearman"s rho 0.43, p &lt; = 0.0001).	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
15626301-4	2004	In this work the author reviews some earlier analyses of the chemical composition of water in Kanjiza spa.	Water	85-90	surfactant protein A2	Homo sapiens	102-105
15499769-3	2004	The Yucheon water had the highest level of electrical conductivity and SO4(2-) due to inflow of mis-treated wastewater from industrial districts.	Water	12-17	muellerian-inhibiting factor	Sus scrofa	96-99
15344726-1	2004	First aid from the water tap? Better not!	Water	19-24	nuclear RNA export factor 1	Homo sapiens	25-29
15969380-1	2004	Previous work has demonstrated that semifluorinated alkanes CnF2n+1CmH2m+1 (FnHm diblocks), when used in conjunction with phospholipids, strongly stabilize fluorocarbon (FC)-in-water emulsions destined to be used as oxygen carriers.	Water	177-182	NPHS1 adhesion molecule, nephrin	Homo sapiens	60-63
15209823-0	2004	Contact allergy to 1-bromo-3-chloro-5, 5-dimethylhydantoin in spa water.	Water	66-71	surfactant protein A2	Homo sapiens	62-65
15097021-6	2004	Cumulative exposure to trihalomethanes was estimated by combining individual year-by-year average trihalomethane level and daily tap water consumption.	Water	133-138	nuclear RNA export factor 1	Homo sapiens	129-132
15165362-7	2004	The correlation of higher serum S100B levels with poor water maze performance may result from injury induced opening of the blood-brain barrier, allowing the passage of S100B into serum.	Water	55-60	S100 calcium binding protein B	Rattus norvegicus	32-37
15090668-8	2004	The total fluid intake was 18.9 l/week of which, on average, 18% was cold tap water; 30% of this tap water was consumed outside the home.	Water	78-83	nuclear RNA export factor 1	Homo sapiens	74-77
15090668-8	2004	The total fluid intake was 18.9 l/week of which, on average, 18% was cold tap water; 30% of this tap water was consumed outside the home.	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
15066755-5	2004	At neutral pH, GALA is water soluble while at acid pH, GALA binds to bilayer membranes.	Water	23-28	galactosidase alpha	Homo sapiens	15-19
15066441-0	2004	MHC-peptide binding is assisted by bound water molecules.	Water	41-46	major histocompatibility complex, class I, C	Homo sapiens	0-3
15066441-1	2004	Water plays an important role in determining the high affinity of epitopes to the class I MHC complex.	Water	0-5	major histocompatibility complex, class I, C	Homo sapiens	90-93
15066441-2	2004	To study the energy and dynamics of water interactions in the complex we performed molecular dynamics simulation of the class I MHC-HLA2 complex bound to the HIV reverse transcriptase epitope, ILKEPVHGV, and in the absence of the epitope.	Water	36-41	major histocompatibility complex, class I, C	Homo sapiens	128-131
15066441-4	2004	We studied the processes of water penetration in the interface between MHC and peptide, and identified 14 water molecules that stay bound for periods longer than 1ns in regions previously identified by crystallography.	Water	28-33	major histocompatibility complex, class I, C	Homo sapiens	71-74
15066441-4	2004	We studied the processes of water penetration in the interface between MHC and peptide, and identified 14 water molecules that stay bound for periods longer than 1ns in regions previously identified by crystallography.	Water	106-111	major histocompatibility complex, class I, C	Homo sapiens	71-74
15066441-5	2004	These water molecules in the interface perform definite "tasks" contributing to the binding energy: hydrogen bond bridges between MHC and peptide and filling empty spaces in the groove which enhance affinity without contributing to epitope specificity.	Water	6-11	major histocompatibility complex, class I, C	Homo sapiens	130-133
15066441-6	2004	We calculate the binding energy for interfacial water molecules and find that there is an overall gain in free energy resulting from the formation of water clusters at the epitope-MHC interface.	Water	48-53	major histocompatibility complex, class I, C	Homo sapiens	180-183
15066441-6	2004	We calculate the binding energy for interfacial water molecules and find that there is an overall gain in free energy resulting from the formation of water clusters at the epitope-MHC interface.	Water	150-155	major histocompatibility complex, class I, C	Homo sapiens	180-183
15066441-8	2004	We conclude that water molecules at the interface play the role of active mediators in the MHC-peptide interaction, and might be responsible for the large binding affinity of the MHC complex to a large number of epitope sequences.	Water	17-22	major histocompatibility complex, class I, C	Homo sapiens	91-94
15066441-8	2004	We conclude that water molecules at the interface play the role of active mediators in the MHC-peptide interaction, and might be responsible for the large binding affinity of the MHC complex to a large number of epitope sequences.	Water	17-22	major histocompatibility complex, class I, C	Homo sapiens	179-182
15053633-8	2004	HO3-/H2O3 may be the bactericidal trioxide recently identified in the antibody-catalyzed addition of O2(1Deltag) to H2O.	Water	5-8	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-3
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Water	226-231	nth like DNA glycosylase 1	Homo sapiens	70-75
15028527-1	2004	Previous studies using the fresh water turtle Chrysemys picta have demonstrated the differential expression of the two progesterone receptor isoforms (PRA and PRB) in the liver during the turtle seasonal cycle, correlating with ER mRNA levels and hepatic vitellogenesis.	Water	33-38	progesterone receptor	Chrysemys picta	119-140
15070970-1	2004	Autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) is a defect in free water conservation caused by mutations in the single gene that encodes both vasopressin (VP) and its binding protein, neurophysin II (NP II).	Water	83-88	neuronal pentraxin 2	Homo sapiens	201-215
15016444-3	2004	The goal of the present study is to investigate the influence of water quality and the geographic location of consumers within a distribution system on consumer perception of tap water.	Water	65-70	nuclear RNA export factor 1	Homo sapiens	175-178
15156914-4	2004	Finally, using stochastic simulations of different strategies for controlling ballast-water introductions, we find that reducing the per-ship-visit chance of causing invasion is more effective in reducing the rate of biotic homogenization than eliminating key ports that are the epicentres for global spread.	Water	86-91	inositol polyphosphate-5-phosphatase D	Homo sapiens	137-141
15043281-4	2004	The benefits of UV photooxidation on TOC reduction for LC-MS studies were highlighted using electrospray ionization MS detection by comparing HPLC-grade bottled water, freshly produced UV185/254-treated water, and freshly produced non-UV-treated water.	Water	203-208	rhomboid 5 homolog 2	Homo sapiens	37-40
15004190-4	2004	Seven days after consuming 3% dextran sulfate sodium in their drinking water, Daf1(-/-) mice suffered markedly greater weight loss (-24.7 +/- 7.5% vs -14.2% +/- 4.9%), exhibited uniformly bloody diarrhea as compared with soft stool in control mice, developed shortened colons, and had larger spleens.	Water	71-76	CD55 molecule, decay accelerating factor for complement	Mus musculus	78-82
15072421-8	2004	CONCLUSIONS: These results indicate that guanylin and uroguanylin in the nasal mucosa may participate in normal physiological processes, but also suggest that altered expression of these genes in nasal polyps may cause impaired electrolyte and water transport across the epithelial cells.	Water	244-249	guanylate cyclase activator 2B	Homo sapiens	54-65
14734638-3	2004	A selective removal of perivascular AQP4 by alpha-syntrophin deletion delays the buildup of brain edema (assessed by Diffusion-weighted MRI) following water intoxication, despite the presence of a normal complement of endothelial AQP4.	Water	151-156	aquaporin 4	Homo sapiens	36-40
15060497-11	2004	Tap water exhibited the highest incidence of leakage, sterile water the least, with the other irrigation solutions leading to intermediate leakage.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
14971482-1	2004	An automated spray-and-trap (ST) chromatographic system was constructed for fast and efficient extraction of volatile organic compounds (VOCs) in aqueous samples with the capability to be deployed in the field for unattended continuous monitoring of surface or ground water.	Water	268-273	TRAP	Homo sapiens	13-27
14576087-0	2004	Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method.	Water	26-31	aquaporin 4	Mus musculus	80-85
14576087-7	2004	Temperature dependence studies indicated an increased Arrhenius activation energy for water transport in AQP-4-deficient astrocytes (11.3 +/- 0.5 vs. 5.5 +/- 0.4 kcal/mol).	Water	86-91	aquaporin 4	Mus musculus	105-110
14576087-8	2004	Our studies establish a calcein quenching method for measurement of cell membrane water permeability and indicate that AQP-4 provides the principal route for water transport in astrocytes.	Water	158-163	aquaporin 4	Mus musculus	119-124
14986461-10	2004	The mean iodine concentration for tap drinking water was 22.8 micrograms/L (range 0.5-53.5 micrograms/L) and for mineral water 7 micrograms/L (range 0-15 micrograms/L).	Water	47-52	nuclear RNA export factor 1	Homo sapiens	34-37
14754982-3	2004	GER is common in infants, which is related to their large fluid intake (corresponding to 14 L/day in an adult) and supine body position, resulting in the gastroesophageal junction"s being constantly "under water."	Water	206-211	GER	Homo sapiens	0-3
14670634-8	2004	Our results report a heterogeneous distribution of the neuronal populations that co-localize AT(1A) receptor and Fos protein in the lamina terminalis after an acute Na(+) and water depletion.	Water	175-180	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-116
14532297-6	2004	Transiently transfected cells expressing CYP26C1 convert atRA to polar water-soluble metabolites similar to those generated by CYP26A1 and -B1.	Water	71-76	cytochrome P450 family 26 subfamily C member 1	Homo sapiens	41-48
14663545-9	2004	The analytical procedure was successfully applied to several samples of tap water and the results were in good agreement with those from AAS determination.	Water	76-81	nuclear RNA export factor 1	Homo sapiens	72-75
14695279-0	2004	Comparison of the effect of water release on the interaction of the Saccharomyces cerevisiae TATA binding protein (TBP) with "TATA Box" sequences composed of adenosine or inosine.	Water	28-33	TATA-binding protein	Saccharomyces cerevisiae S288C	93-113
14695279-0	2004	Comparison of the effect of water release on the interaction of the Saccharomyces cerevisiae TATA binding protein (TBP) with "TATA Box" sequences composed of adenosine or inosine.	Water	28-33	TATA-binding protein	Saccharomyces cerevisiae S288C	115-118
14695279-1	2004	The formation of sequence-specific complexes of TATA binding protein (TBP) with the minor groove of DNA results in the burial of large nonpolar surfaces and the exclusion of water from these interfaces.	Water	174-179	TATA-binding protein	Saccharomyces cerevisiae S288C	48-68
14695279-1	2004	The formation of sequence-specific complexes of TATA binding protein (TBP) with the minor groove of DNA results in the burial of large nonpolar surfaces and the exclusion of water from these interfaces.	Water	174-179	TATA-binding protein	Saccharomyces cerevisiae S288C	70-73
14695279-2	2004	The release of water is thus expected to provide a significant entropic driving force for formation of the transcription-preinitiated complexes mediated by the binding of TBP to specific sequences.	Water	15-20	TATA-binding protein	Saccharomyces cerevisiae S288C	171-174
14695279-8	2004	However, approximately 18 additional molecules of water are released upon TBP binding the TATAAAAG as compared with the TITIIIIG sequence resulting in an entropic advantage to the binding of the natural promoter sequence.	Water	50-55	TATA-binding protein	Saccharomyces cerevisiae S288C	74-77
15499565-1	2004	The conformational features of a peptide derived by the 10-30 sequence of the mitochondrial domain of AKAP121 [Ac-1XKKPLALPGMLALLGWWWFFSRKKX25-NH2 (X=beta-Ala)] in water and in a water/trifluoroethanol (TFE) mixture at 298 K have been determined by NMR and CD spectroscopy.	Water	164-169	A-kinase anchoring protein 1	Homo sapiens	102-109
15499565-1	2004	The conformational features of a peptide derived by the 10-30 sequence of the mitochondrial domain of AKAP121 [Ac-1XKKPLALPGMLALLGWWWFFSRKKX25-NH2 (X=beta-Ala)] in water and in a water/trifluoroethanol (TFE) mixture at 298 K have been determined by NMR and CD spectroscopy.	Water	179-184	A-kinase anchoring protein 1	Homo sapiens	102-109
15651116-6	2004	Patients with a higher O antibody titre (&gt; or = 1 in 80) by Widal test were found to have consumed both tap water and pure water.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
15281891-2	2004	Among different AQPs, AQP4 is the predominant water channel in the brain and is thought to play a significant role in the physiopathology of brain edema.	Water	46-51	aquaporin 4	Homo sapiens	22-26
15546402-9	2004	Mycobacteria were also detected in tap water and their number was increased 10(3)-10(4)-fold higher after storage.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
27820018-26	2004	CONCLUSIONS: Current RCT evidence suggests the use of a surgical sterile catheterisation technique is not required, and that tap water is sufficient for cleaning genitalia.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
15561405-11	2004	In conjuncture, the brain appears to have a distinct astrocytic perivascular system, involving several potassium channels as well as aquaporin 4, a membrane water channel, which has been localized to astrocytic endfeet and mediate water fluxes within the brain.	Water	157-162	aquaporin 4	Homo sapiens	133-144
15561405-11	2004	In conjuncture, the brain appears to have a distinct astrocytic perivascular system, involving several potassium channels as well as aquaporin 4, a membrane water channel, which has been localized to astrocytic endfeet and mediate water fluxes within the brain.	Water	231-236	aquaporin 4	Homo sapiens	133-144
15561407-1	2004	Aquaporin-4 (AQP4) is the predominant water channel in the neuropil of the central nervous system.	Water	38-43	aquaporin 4	Homo sapiens	0-11
15561407-1	2004	Aquaporin-4 (AQP4) is the predominant water channel in the neuropil of the central nervous system.	Water	38-43	aquaporin 4	Homo sapiens	13-17
15561407-6	2004	We propose that AQP4 works in concert with Kir4.1 and the electrogenic bicarbonate transporter NBC and that water flux through AQP4 contributes to the activity dependent volume changes of the extracellular space.	Water	108-113	aquaporin 4	Homo sapiens	127-131
15561407-8	2004	We conclude that AQP4-mediated water flux represents an integral element of brain volume and ion homeostasis.	Water	31-36	aquaporin 4	Homo sapiens	17-21
15561408-4	2004	Most of that efflux is through AQP4 water channels concentrated in astrocyte endfeet that surround capillaries and form the glia limitans.	Water	36-41	aquaporin 4	Homo sapiens	31-35
15561409-1	2004	Aquaporin-4 (AQP4) is the major water channel expressed in brain perivascular astrocyte processes.	Water	32-37	aquaporin 4	Mus musculus	0-11
15329882-3	2004	Thus, the reactions of H3O+(H2O)0,1,2,3 ions with HCN molecules have been studied in the presence of varying concentrations of water vapour, reactions on which SIFT-MS analysis of HCN relies.	Water	28-31	H3 clustered histone 15	Homo sapiens	23-26
15329882-3	2004	Thus, the reactions of H3O+(H2O)0,1,2,3 ions with HCN molecules have been studied in the presence of varying concentrations of water vapour, reactions on which SIFT-MS analysis of HCN relies.	Water	127-132	H3 clustered histone 15	Homo sapiens	23-26
14670455-6	2004	The changes in the vibrational characteristics (vibrational frequencies and infrared intensities) arising from the hydrogen bonding between HONO2 and H2O have been estimated by using the ab initio calculations at SCF and MP2 levels and B3LYP/6-31G(d,p) calculations.	Water	150-153	KIT ligand	Homo sapiens	213-216
14690388-6	2003	In experiments using high-performance liquid chromatography-UV spectroscopy (HPLC-UV) and HPLC tandem mass spectrometry (HPLC-MS/MS), DKN was found to rapidly react with hypochlorite in tap water, yielding the BA metabolite as the major end product.	Water	190-195	nuclear RNA export factor 1	Homo sapiens	186-189
14690388-7	2003	One milligram per liter (19 microM) of hypochlorite residue in tap water was able to completely oxidize up to 1600 microg/L (4.45 micromol/L) of DKN.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
14690388-8	2003	In tap water, the disappearance of IXF was much more rapid than in DI water.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	3-6
14690388-10	2003	As a result, the herbicide solutions prepared with tap water at 500 microg/L will no longer possess any herbicidal activity after 48 h of storage.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
14690388-11	2003	However, in agronomic settings, highly concentrated tank solutions (600-800 mg/L) may be prepared with tap water since the conversion of IXF to BA would represent &lt;5% of the herbicide; therefore, any impact on the herbicide efficacy would be negligible.	Water	107-112	nuclear RNA export factor 1	Homo sapiens	103-106
14646095-2	2003	A water-soluble chlorophyll protein (WSCP) with a chlorophyll a:b ratio of 6:1 from Brassica oleracea L. var.	Water	2-7	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	37-41
15049356-5	2003	In-water measurements are used to establish the relationship between the PAR and the spectral attenuation coefficient in the Baltic Sea via regression analysis.	Water	3-8	jumping translocation breakpoint	Homo sapiens	73-76
14680363-2	2003	To understand this variability, we studied the relationship between polymorphisms in the gene for human monomethylarsonic acid (MMA(V)) reductase/hGSTO1 and the urinary arsenic profiles of individuals chronically exposed to arsenic in their drinking water.	Water	250-255	glutathione S-transferase omega 1	Homo sapiens	128-145
14680363-2	2003	To understand this variability, we studied the relationship between polymorphisms in the gene for human monomethylarsonic acid (MMA(V)) reductase/hGSTO1 and the urinary arsenic profiles of individuals chronically exposed to arsenic in their drinking water.	Water	250-255	glutathione S-transferase omega 1	Homo sapiens	146-152
14636948-2	2003	Cerebral water content is regulated by aquaporin 4 (AQ4) present in astrocytic end feet and around blood vessels.	Water	9-14	aquaporin 4	Mus musculus	39-50
14636948-2	2003	Cerebral water content is regulated by aquaporin 4 (AQ4) present in astrocytic end feet and around blood vessels.	Water	9-14	aquaporin 4	Mus musculus	52-55
14610562-6	2003	The mean fluoride intake for 4-18-year-olds when the source of water intake is solely fluoridated tap water was estimated to be 0.26 mg F per day; compared with 0.16 mg F per day, when a combination of tap and bottled water is consumed.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
14610562-6	2003	The mean fluoride intake for 4-18-year-olds when the source of water intake is solely fluoridated tap water was estimated to be 0.26 mg F per day; compared with 0.16 mg F per day, when a combination of tap and bottled water is consumed.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
14610562-8	2003	Consumption of bottled water containing a negligible amount of fluoride in preference to fluoridated tap water might result in less than optimal fluoride ingestion in young people.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
15049550-3	2003	Table water is bottled purified water subject to the same requisites as tap water, whatever its original characteristics, during the process of purification, it can be modified to render it ideal for the needs of the consumer.	Water	6-11	nuclear RNA export factor 1	Homo sapiens	72-75
15049556-4	2003	(Local Health Unit) in collaboration with the Institute of Hygiene of the Catholic University of Rome carried out a survey to evaluate perception towards tap water quality in a sample of students.	Water	158-163	nuclear RNA export factor 1	Homo sapiens	154-157
14599843-8	2003	Primed T cells of IRBP-/- mice transferred an exacerbated form of EAU to nai;ve wild type recipients.	Water	66-69	retinol binding protein 3, interstitial	Mus musculus	18-22
14620452-6	2003	About 87% of formula fed children had tap water added to the bottle.	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
14682896-4	2003	Depending on the laser spot speed, compressional waves formed a Mach cone and multiple lateral or transverse wakes, similar to ship wakes on the water surface, due to a combination of acoustic and dispersive properties.	Water	145-150	inositol polyphosphate-5-phosphatase D	Homo sapiens	127-131
14573854-7	2003	This nanosecond dispersion may reflect intersite exchange of water molecules trapped inside the large binding cavity of BLG-A.	Water	61-66	beta-lactoglobulin	Bos taurus	120-123
14563709-6	2003	GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and on epithelial cell growth and differentiation.	Water	84-89	guanylate cyclase activator 2B	Homo sapiens	42-53
14530451-8	2003	The catalytic constant of glutaminyl-tRNA synthetase increases with increasing osmotic pressure indicating a water release of 8.4 +/- 1.4 mol/mol in the transition state, whereas little change is seen in the case of glutamyl-tRNA synthetase.	Water	109-114	glutaminyl-tRNA synthetase 1	Homo sapiens	26-52
14530451-9	2003	We propose that the significant amount of water release in the transition state, in the case of glutaminyl-tRNA synthetase, is due to additional contact of the protein with the tRNA in the transition state.	Water	42-47	glutaminyl-tRNA synthetase 1	Homo sapiens	96-122
14550556-3	2003	Photometric measurements in the isolated thylakoid membranes of hf-2 revealed that the lowered activity in the mutant was derived from a decrease in the efficiency of the electron donation from water to tyrosine Z, not from the efficiency of the electron transport from Q(A) to Q(B).	Water	194-199	complement factor H	Homo sapiens	64-68
14556666-7	2003	The odds ratios (95% confidence intervals) were 0.73 (0.55-0.96) for tap water, 0.72 (0.63-0.84) for flush toilets, 0.74 (0.66-0.83) for urban location, 1.34 (1.09-1.64) for 7 or more people in the household, 1.19 (1.00-1.41) for 4th or 5th in birth order, and 1.47 (1.17-1.85) for 6th or more in birth order.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
14684951-4	2003	They wore cotton underwear, which they had washed in cold tap water.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
14669973-5	2003	A strong linear correlation between low-melting TAG/water partition coefficients and lipid phase molarity was validated by volatile partition data of C6, C11, and C16 alkane/water systems.	Water	52-57	RNA polymerase III subunit K	Homo sapiens	154-157
14621355-2	2003	Common household bleach containing 5.25% sodium hypochlorite, diluted in a 1:10 ratio with tap water, is a safe and effective method to reduce colony-forming units per milliliter (CFU/ml) to a study-defined acceptable range of 100 CFU/ml when a standard procedure was consistently used.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
12972251-6	2003	The interactions made by human TFIIA with TBP and DNA within and upstream of the TATA box, including those involving water molecules, are described and compared to the yeast structure.	Water	117-122	TATA-box binding protein	Homo sapiens	42-45
12971755-5	2003	In Ca1 the solid state assembly is attained by a polymeric association of [(CaL1(H2O))2(mu-OH2)] dimeric units.	Water	81-84	carbonic anhydrase 1	Homo sapiens	3-6
12957366-0	2003	A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats.	Water	8-13	corticotropin releasing hormone receptor 1	Rattus norvegicus	32-36
12957366-3	2003	A novel water-soluble tricyclic CRF1 antagonist, NBI 35965 was developed that displayed a high affinity for CRF1 (Ki approximately 4 nM) while having no binding affinity to CRF2.	Water	8-13	corticotropin releasing hormone receptor 1	Rattus norvegicus	32-36
12957366-3	2003	A novel water-soluble tricyclic CRF1 antagonist, NBI 35965 was developed that displayed a high affinity for CRF1 (Ki approximately 4 nM) while having no binding affinity to CRF2.	Water	8-13	corticotropin releasing hormone receptor 1	Rattus norvegicus	108-112
12957366-13	2003	The data show that NBI 35965 is a novel water-soluble selective CRF1 antagonist with bioavailability to the brain upon peripheral administration and that CRF1 receptor signaling pathways are involved in water avoidance stress-induced hyperalgesia to colorectal distention and stimulation of colonic transit.	Water	40-45	corticotropin releasing hormone receptor 1	Rattus norvegicus	64-68
12957366-13	2003	The data show that NBI 35965 is a novel water-soluble selective CRF1 antagonist with bioavailability to the brain upon peripheral administration and that CRF1 receptor signaling pathways are involved in water avoidance stress-induced hyperalgesia to colorectal distention and stimulation of colonic transit.	Water	203-208	corticotropin releasing hormone receptor 1	Rattus norvegicus	154-158
12941322-0	2003	Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.	Water	78-83	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	27-32
12941322-1	2003	Previously, it had been reported that 6-(phosphonodifluoromethyl)-2-naphthoic acid binds to the protein-tyrosine phosphatase PTP1B with its 2-carboxyl group interacting only indirectly through a bridging water molecule.	Water	204-209	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	125-130
12738610-3	2003	Central injection of ANG II (10 ng/2 microl) into the lateral cerebroventricle (icv) of Sprague-Dawley rats increased water intake in a time-dependent manner.	Water	118-123	angiogenin	Rattus norvegicus	21-24
12959586-6	2003	A peptide-cross-linked hydrogel with a 97/3 molar ratio of NIPAAm/AAc exhibited a LCST of approximately 34.5 degrees C. Swelling was influenced by NIPAAm/AAc monomer ratio, cross-linking density, and swelling media; however, all hydrogels maintained more than 90% water even at 37 degrees C. In enzymatic degradation studies, breakdown of the peptide-cross-linked P(NIPAAm-co-AAc) hydrogels was dependent on both the concentration of collagenase and the cross-linking density.	Water	264-269	glycine-N-acyltransferase	Homo sapiens	66-69
12873729-3	2003	Water deprivation for 24 h and 2 and 4 days and salt loading for 7 days caused a significant increase in the BDNF gene transcripts in the SFO, compared with euhydrated rats.	Water	0-5	brain-derived neurotrophic factor	Rattus norvegicus	109-113
12900507-0	2003	Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities.	Water	134-139	transthyretin	Homo sapiens	55-68
12824287-0	2003	Inhibition of aquaporin-4 expression in astrocytes by RNAi determines alteration in cell morphology, growth, and water transport and induces changes in ischemia-related genes.	Water	113-118	aquaporin 4	Homo sapiens	14-25
12824287-1	2003	Recent studies indicate a key role of aquaporin (AQP) 4 in astrocyte swelling and brain edema and suggest that AQP4 inhibition may be a new therapeutic way for reducing cerebral water accumulation.	Water	178-183	aquaporin 4	Homo sapiens	49-55
12824287-1	2003	Recent studies indicate a key role of aquaporin (AQP) 4 in astrocyte swelling and brain edema and suggest that AQP4 inhibition may be a new therapeutic way for reducing cerebral water accumulation.	Water	178-183	aquaporin 4	Homo sapiens	111-115
12824287-5	2003	Water transport measurements showed that the rate of shrinkage of AQP4 knockdown astrocytes was one-half of that of controls.	Water	0-5	aquaporin 4	Homo sapiens	66-70
12824287-7	2003	Taken together, these results indicate that 1) AQP4 seems to be the major factor responsible for the fast water transport of cultured astrocytes; 2) as in skeletal muscle, AQP4 is a protein involved in cell plasticity; 3) AQP4 alteration may be a primary factor in ischemia-induced cerebral edema; and 4) RNA interference could be a new potent tool for studying AQP pathophysiology in those organs and tissues where they are expressed.	Water	106-111	aquaporin 4	Homo sapiens	47-51
12824287-7	2003	Taken together, these results indicate that 1) AQP4 seems to be the major factor responsible for the fast water transport of cultured astrocytes; 2) as in skeletal muscle, AQP4 is a protein involved in cell plasticity; 3) AQP4 alteration may be a primary factor in ischemia-induced cerebral edema; and 4) RNA interference could be a new potent tool for studying AQP pathophysiology in those organs and tissues where they are expressed.	Water	106-111	aquaporin 4	Homo sapiens	172-176
12824287-7	2003	Taken together, these results indicate that 1) AQP4 seems to be the major factor responsible for the fast water transport of cultured astrocytes; 2) as in skeletal muscle, AQP4 is a protein involved in cell plasticity; 3) AQP4 alteration may be a primary factor in ischemia-induced cerebral edema; and 4) RNA interference could be a new potent tool for studying AQP pathophysiology in those organs and tissues where they are expressed.	Water	106-111	aquaporin 4	Homo sapiens	172-176
12936882-3	2003	The city water where I live is loaded with phosphates and other minerals, so I"m worried that my tap water doesn"t meet the definition of "plain water".	Water	9-14	nuclear RNA export factor 1	Homo sapiens	97-100
12936882-3	2003	The city water where I live is loaded with phosphates and other minerals, so I"m worried that my tap water doesn"t meet the definition of "plain water".	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
12938971-5	2003	The contribution of drinking water to the total uranium intake is sometimes significant as the uranium concentration range in 29 analyzed tap and bottled "mineral" waters is 0.04-5.86 microg L(-1) and the drinking water consumption about 1 L d(-1) or more.	Water	29-34	nuclear RNA export factor 1	Homo sapiens	138-141
12846749-8	2003	The protein abundance of mTAL BSC1, NHE3, and Na+ pump increased significantly in young but remained unchanged in 7-month-old rats subjected to water deprivation.	Water	144-149	solute carrier family 12 member 1	Rattus norvegicus	30-34
12851114-5	2003	This article presents the results of nine studies, including seven dose reconstruction or simulation studies involving human volunteers, that quantitatively characterize the absorbed dose of Cr(VI) following contact with tap water via all routes of exposure.	Water	225-230	nuclear RNA export factor 1	Homo sapiens	221-224
12851114-9	2003	Based on a physiologically based pharmacokinetic model for chromium derived from published studies, coupled with the dose reconstruction studies presented in this article, the available information clearly indicates that (1) Cr(VI) ingested in tap water at concentrations below 2 mg/L is rapidly reduced to Cr(III), and (2) even trace amounts of Cr(VI) are not systemically circulated.	Water	248-253	nuclear RNA export factor 1	Homo sapiens	244-247
12851114-10	2003	This assessment indicates that exposure to Cr(VI) in tap water via all plausible routes of exposure, at concentrations well in excess of the current U.S. Environmental Protection Agency (EPA) maximum contaminant level of 100 microg/L (ppb), and perhaps those as high as several parts per million, should not pose an acute or chronic health hazard to humans.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
12842287-5	2003	The number of Fos-positive neurons following intestinal anaphylaxis decreased in animals exposed to water-avoidance stress (P &lt; 0.05), although serum levels of rat mast cell protease II were not different in stressed and unstressed animals, indicating a similar degree of mast cell degranulation.	Water	100-105	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
12730191-6	2003	RNase protection assays showed that TTF-1 and angiotensinogen mRNA levels are simultaneously increased in the subfornical organ by water deprivation.	Water	131-136	transcription termination factor 1	Rattus norvegicus	36-41
12730191-10	2003	Intracranial administration of an antisense TTF-1 oligodeoxynucleotide decreased angiotensinogen mRNA in the subfornical organ and dramatically reduced the animal"s water intake while increasing urine excretion.	Water	165-170	transcription termination factor 1	Rattus norvegicus	44-49
12763537-3	2003	In addition HPLC method depending on using RP18 column with a mobile phase consisting of acetonitrile-water (30:70, v/v, pH 3.2) with UV detection at 305 nm was developed.	Water	102-107	pre-mRNA processing factor 3	Homo sapiens	43-47
12775063-19	2003	The calibration curve displayed a similar pattern as did those for other matrixes, including PBS and tap water, although its sensitivity was a little less due to the interference with certain components in the surface water.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
12660990-2	2003	In bacterial forms of DHFR both substrate and water access to the active site are controlled by the conformation of the mobile M20 loop.	Water	46-51	dihydrofolate reductase	Gallus gallus	22-26
12660990-11	2003	These results indicated that water can serve as the Broensted acid for the protonation of N5 of dihydrofolate during the DHFR catalyzed reduction.	Water	29-34	dihydrofolate reductase	Gallus gallus	121-125
12708850-1	2003	When the primary electron-donation pathway from the water-oxidation complex in photosystem II (PS II) is inhibited, chlorophyll (Chl(Z) and Chl(D)), beta-carotene (Car) and cytochrome b(559) are alternate electron donors that are believed to function in a photoprotection mechanism.	Water	52-57	mitochondrially encoded cytochrome b	Homo sapiens	173-185
12684481-2	2003	GLP-1 is also a brain neuropeptide that has diverse central actions, including inhibition of food and water intake, gastric emptying, and stimulation of neuroendocrine responses characteristic of visceral illness.	Water	102-107	glucagon	Rattus norvegicus	0-5
12733644-9	2003	In conclusion, the topically applied water-soluble antioxidants ASC, NAC and CYSET protect against UVA-induced decomposition of SUP by scavenging radicals and ROS.	Water	37-42	X-linked Kx blood group	Homo sapiens	69-72
12601783-10	2003	These results indicate that elastin is the major regulatory component of BHV calcification, and preventive effects on calcification increased only when CEM were pretreated with first ethanol and then EDTA in water solution.	Water	208-213	elastin	Rattus norvegicus	28-35
12658103-7	2003	Startle probability and magnitude was greater in water-treated LAD1 rats than in water-treated HAD1 rats.	Water	49-54	ladinin 1	Rattus norvegicus	63-67
12745350-4	2003	An interquartile range increase in effluent water turbidity of 0.8 Nephelometric Turbidity Units was associated with a relative risk of self-reported GI illness of 1.47 (95% Confidence Interval 1.16, 1.86) at a lag of 2 days after control for daily rate of consumption of non-boiled tap water, behavioural covariates, day of the week and a seasonally-related linear trend.	Water	44-49	nuclear RNA export factor 1	Homo sapiens	283-286
12529272-1	2003	We examined the hemodynamic and tubular transport mechanisms by which platelet-activating factor (PAF) regulates salt and water excretion.	Water	122-127	PCNA clamp associated factor	Rattus norvegicus	70-96
12529272-1	2003	We examined the hemodynamic and tubular transport mechanisms by which platelet-activating factor (PAF) regulates salt and water excretion.	Water	122-127	PCNA clamp associated factor	Rattus norvegicus	98-101
12605265-3	2003	METHODS: B10.A mice were immunized with 50 micro g of interphotoreceptor retinoid binding protein (IRBP) emulsified in complete Freund"s adjuvant in order to induce EAU.	Water	165-168	retinol binding protein 3, interstitial	Mus musculus	54-97
12605265-3	2003	METHODS: B10.A mice were immunized with 50 micro g of interphotoreceptor retinoid binding protein (IRBP) emulsified in complete Freund"s adjuvant in order to induce EAU.	Water	165-168	retinol binding protein 3, interstitial	Mus musculus	99-103
12558829-0	2003	Hot-water epilepsy.	Water	4-9	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
12602823-4	2003	The rate of degradation was more in tap water as compared to rain and distilled water.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
12635833-4	2003	Arsenic safe drinking water is provided for adopted villages by constructing shallow, concrete dugwells designed to tap the water of the unconfined aquifer, 20-30 feet below ground level, that contains low levels (&lt; 0.05 mg/L) of arsenic in the target region.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	116-119
12546247-2	2003	The contaminated water was filtered through a Berkefeld Filter, type TWA 3, as used by the Norwegian army.	Water	17-22	M-phase phosphoprotein 8	Homo sapiens	69-74
12629269-11	2003	Water restriction resulted in increased signals for rBSC1 mRNA and protein and concentration of urine in sham-operated rats, but such increases were absent and urinary concentration was incomplete in CRF rats.	Water	0-5	solute carrier family 12 member 1	Rattus norvegicus	52-57
12495337-1	2002	The suitability of the system [Fe(4,4"-bipy)(H(2)O)(2)(NCX)(2)].	Water	45-50	T cell leukemia homeobox 2	Homo sapiens	55-58
12444076-3	2002	Binding of ligands to GC-C leads to accumulation of intracellular cGMP, the activation of protein kinases G and A, and phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel that regulates salt and water secretion.	Water	245-250	guanylate cyclase 2C	Rattus norvegicus	22-26
12457460-26	2002	Perinatal malnutrition also affects the responsiveness to water deprivation with alterations in both hypothalamic VP gene expression and regulation of ANP-binding sites.	Water	58-63	natriuretic peptide A	Rattus norvegicus	151-154
12433939-6	2002	In lung, AQP1 and AQP5 provide the principal route for osmotically driven water transport; however, alveolar fluid clearance in the neonatal and adult lung is not affected by AQP deletion nor is lung CO(2) transport or fluid accumulation in experimental models of lung injury.	Water	74-79	aquaporin 5	Mus musculus	18-22
12433939-7	2002	In the airways, AQP3 and AQP4 facilitate water transport; however, airway hydration, regulation of the airway surface liquid layer, and isosmolar fluid absorption are not impaired by AQP deletion.	Water	41-46	aquaporin 4	Mus musculus	25-29
12432032-1	2002	The interrelationship among water-stress-induced abscisic acid (ABA) accumulation, the generation of reactive oxygen species (ROS), and the activities of several antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and glutathione reductase (GR) was investigated in leaves of detached maize (Zea mays L.) plants exposed to -0.7 MPa water stress induced by polyethylene glycol (PEG 6000).	Water	28-33	APx1-Cytosolic Ascorbate Peroxidase	Zea mays	234-254
12432032-1	2002	The interrelationship among water-stress-induced abscisic acid (ABA) accumulation, the generation of reactive oxygen species (ROS), and the activities of several antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and glutathione reductase (GR) was investigated in leaves of detached maize (Zea mays L.) plants exposed to -0.7 MPa water stress induced by polyethylene glycol (PEG 6000).	Water	28-33	APx1-Cytosolic Ascorbate Peroxidase	Zea mays	256-259
12545634-9	2002	Enemas are done twice a week, they last on average one hour with an average of 3 litres of liquid, usually tap water.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
12473417-4	2002	This study measures the mass of Cr(6+) released from particles originating from three types of paint particles: solvent-borne epoxy, water-borne epoxy, and polyurethane.	Water	133-138	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	32-38
12473417-8	2002	The mean fractions of Cr(6+) released into the water after 1 and 24 hours for each primer averaged: 70 and 85 (solvent epoxy), 74 and 84% (water epoxy), and 94 and 95% (polyurethane).	Water	47-52	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	22-28
19003104-2	2002	When mice were supplied with water supplemented with 2% OVA ad libitum, the faecal OVA-specific immunoglobulin A (IgA) level significantly increased in those fed a nucleotide-supplemented diet (NT(+) diet) compared with those fed a nucleotide-free control diet (NT(-) diet).	Water	29-34	immunoglobulin heavy constant alpha	Mus musculus	114-117
12183447-2	2002	It has been hypothesized that in the absence of or under nonsaturating levels of L-arginine where O(2) reduction is the primary outcome of NOS activation, H(4)B promotes the generation of H(2)O(2) at the expense of O(2)(-.).	Water	188-193	H4 clustered histone 4	Homo sapiens	155-160
12361943-7	2002	Children 1 year old showed the highest rate of diarrhea during the dry season [odds ratio (OR) = 2.1 with 95% confidence interval (CI), 0.99-4.71], particularly those from households perceiving unpleasant taste of tap water (OR, 1.7; 95% CI, 0.97-2.92) and consuming vegetables washed only with water (OR, 2.2; 95% CI, 1.10-4.39).	Water	218-223	nuclear RNA export factor 1	Homo sapiens	214-217
12362104-9	2002	During exercise, the number of subjects with a phase III was higher with CHO than with tap water (n =6 v. n =1; P &lt; 0.05).	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
12405973-9	2002	Long-term potentiation (LTP) in response to high-frequency CA3 stimulation was induced reliably and maintained over 60 min in isocaloric-sucrose and water control animals.	Water	149-154	carbonic anhydrase 3	Cavia porcellus	59-62
12364542-1	2002	Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of hydrolyzing triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as well as other lipid and water soluble substrates.	Water	202-207	lipase E, hormone sensitive type	Homo sapiens	0-24
12364542-1	2002	Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of hydrolyzing triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as well as other lipid and water soluble substrates.	Water	202-207	lipase E, hormone sensitive type	Homo sapiens	26-29
12656477-1	2002	We have developed a versatile tool for the delivery of inhibitors of carbonic anhydrase II, which allows modification of a hydrophobic drug with either a water-solubilizing, photolabile cage or a hydrophobic, photolabile cage.	Water	154-159	carbonic anhydrase 2	Homo sapiens	69-90
12167608-5	2002	In water-restricted rats, endothelial NOS (eNOS) expression increased in the outer medulla, and neuronal NOS (nNOS) expression rose in both the outer medulla and the papilla.	Water	3-8	nitric oxide synthase 3	Rattus norvegicus	26-41
12167608-5	2002	In water-restricted rats, endothelial NOS (eNOS) expression increased in the outer medulla, and neuronal NOS (nNOS) expression rose in both the outer medulla and the papilla.	Water	3-8	nitric oxide synthase 1	Rattus norvegicus	96-108
12167608-5	2002	In water-restricted rats, endothelial NOS (eNOS) expression increased in the outer medulla, and neuronal NOS (nNOS) expression rose in both the outer medulla and the papilla.	Water	3-8	nitric oxide synthase 1	Rattus norvegicus	110-114
12167608-6	2002	Conversely, water loading induced a decrease in expression of nNOS in the outer medulla and papilla but did not alter eNOS expression.	Water	12-17	nitric oxide synthase 1	Rattus norvegicus	62-66
12167608-10	2002	Because nNOS is specifically expressed in principal cells of the collecting duct system, the stimulation of nNOS expression by AVP may participate in the control of water reabsorption.	Water	165-170	nitric oxide synthase 1	Rattus norvegicus	8-12
12167608-10	2002	Because nNOS is specifically expressed in principal cells of the collecting duct system, the stimulation of nNOS expression by AVP may participate in the control of water reabsorption.	Water	165-170	nitric oxide synthase 1	Rattus norvegicus	108-112
12399690-1	2002	The tap water of Kuopio, Finland, was fluoridated from 1959 to 1992.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
12440767-4	2002	The other components of the respiratory-burst oxidase are water-soluble proteins of cytosolic origin, namely p67phox, p47phox, p40phox and Rac.	Water	58-63	neutrophil cytosolic factor 1	Homo sapiens	118-125
12196423-4	2002	RESULTS: Tap water pH 6.2-6.9 was associated with a fourfold higher risk of type 1 diabetes compared with pH &gt; or =7.7 (OR 3.73, 95% CI 1.52-9.15).	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
12196423-6	2002	Higher tap water concentration of zinc was associated with lower risk of type 1 diabetes after adjustment for pH and other possible confounders, but the overall association was strictly not significant.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	7-10
12192223-5	2002	RESULTS: According to postQ, total water intake was 2.6 liters per day, whereas tap water intake was 0.6 liters per day.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
12192223-6	2002	Intraclass correlation coefficients of postQ compared with preQ were 0.85 for tap water daily intake and 0.77 for duration of showering and bathing.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
12192223-7	2002	Pearson"s correlation coefficients were 0.84 for tap water daily intake, 0.81 for frequency of showering, and 0.94 for bathing.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
12561171-6	2002	Over extracting ground water in oasis district resulted in a forming of dropping funnel of ground water there, and resulted in a fluid of ground water from desert to oasis.	Water	23-28	cAMP responsive element binding protein 3 like 1	Homo sapiens	32-37
12561171-6	2002	Over extracting ground water in oasis district resulted in a forming of dropping funnel of ground water there, and resulted in a fluid of ground water from desert to oasis.	Water	23-28	cAMP responsive element binding protein 3 like 1	Homo sapiens	166-171
12561171-6	2002	Over extracting ground water in oasis district resulted in a forming of dropping funnel of ground water there, and resulted in a fluid of ground water from desert to oasis.	Water	98-103	cAMP responsive element binding protein 3 like 1	Homo sapiens	32-37
12561171-6	2002	Over extracting ground water in oasis district resulted in a forming of dropping funnel of ground water there, and resulted in a fluid of ground water from desert to oasis.	Water	98-103	cAMP responsive element binding protein 3 like 1	Homo sapiens	32-37
12032147-0	2002	Changes in glucose transport and water permeability resulting from the T310I pathogenic mutation in Glut1 are consistent with two transport channels per monomer.	Water	33-38	solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog	Xenopus laevis	100-105
12147471-10	2002	We detected the smallest amount of diatom rbcL expression in the surface water and maximum expression at a depth that coincided with the depth of the subsurface chlorophyll maximum.	Water	73-78	rbcL	Phaeodactylum tricornutum	42-46
11966470-1	2002	We had previously shown that the cholesterol esterification activity of lecithin:cholesterol acyltransferase (LCAT) is destroyed by oxidation, but still it retains the ability to hydrolyse water-soluble substrates.	Water	189-194	lecithin-cholesterol acyltransferase	Homo sapiens	72-108
11966470-1	2002	We had previously shown that the cholesterol esterification activity of lecithin:cholesterol acyltransferase (LCAT) is destroyed by oxidation, but still it retains the ability to hydrolyse water-soluble substrates.	Water	189-194	lecithin-cholesterol acyltransferase	Homo sapiens	110-114
12180960-7	2002	Furthermore, we compare these sections with other forms of amorphous solid water and find it similar to high density amorphous water produced at very high pressures (about 1 GPa) from hexagonal ice and annealed close to its transformation temperature at 117 K.	Water	127-132	glycophorin A	Mus musculus	174-177
12107279-2	2002	For comparison, a molecular dynamics simulation of the conformers of OMP dissolved in water was also studied.	Water	86-91	olfactory marker protein	Homo sapiens	69-72
12107279-5	2002	The conformation of enzyme-bound OMP is very similar to the conformation of OMP in water.	Water	83-88	olfactory marker protein	Homo sapiens	33-36
12107279-5	2002	The conformation of enzyme-bound OMP is very similar to the conformation of OMP in water.	Water	83-88	olfactory marker protein	Homo sapiens	76-79
18968726-1	2002	A simple and sensitive method for the speciation, separation and preconcentration of Cr(VI) and Cr(III) in tap water was developed.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
18968726-12	2002	The proposed method was applied to tap water samples and chromium species have been determined with the relative error &lt;3%.	Water	39-44	nuclear RNA export factor 1	Homo sapiens	35-38
12122115-3	2002	We show here that renin expression and plasma angiotensin II production were increased severalfold in vitamin D receptor-null (VDR-null) mice, leading to hypertension, cardiac hypertrophy, and increased water intake.	Water	203-208	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	127-130
12148328-5	2002	Typically, water passes through three to six such valves before reaching the tap.	Water	11-16	nuclear RNA export factor 1	Homo sapiens	77-80
12010756-0	2002	Ribozyme compromise of adrenomedullin mRNA reveals a physiological role in the regulation of water intake.	Water	93-98	adrenomedullin	Rattus norvegicus	23-37
12099906-11	2002	Moreover, sensorimotor performance on a rotorod was impaired, and water intake was reduced in corticotropin-releasing hormone overproducing mice, while no changes were seen in nociception.	Water	66-71	corticotropin releasing hormone	Mus musculus	94-125
12120840-0	2002	Safe hot tap water and the risk of scalds and legionella infection.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
12186752-11	2002	Its low inhibitory titer and its water solubility suggest that sulfo-SADP reacts with a specific amine (the primary reactant for the succinimidyl group) on cytochrome b(558).	Water	33-38	mitochondrially encoded cytochrome b	Homo sapiens	156-168
12034763-1	2002	Aquaporin (AQP) water channels are expressed in the eye at sites of aqueous fluid production and outflow: AQP1 and AQP4 in nonpigmented ciliary epithelium, and AQP1 in trabecular meshwork endothelium.	Water	16-21	aquaporin 4	Mus musculus	115-119
12126069-7	2002	The second group [control; tap-water-treated] consisted of 15 patients, 8 males (53.3%) and 7 females (46.6%).	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
12040062-10	2002	However, HA-5-HT(1B) expression significantly reduced entrances into the central region of an open-field arena after water-restraint stress without altering overall locomotor activity, but not in the absence of stress exposure.	Water	117-122	5-hydroxytryptamine receptor 1B	Rattus norvegicus	12-19
12137754-2	2002	When treated with CT, water permeability of AQP4 was facilitated while that of AQP3 was suppressed.	Water	22-27	aquaporin 4	Homo sapiens	44-48
12044607-5	2002	Central microinjection of tonin produced a transient (10-20 min) elevation of blood pressure and heart rate and induced water and saline intake within the first 10 min after injection.	Water	120-125	kallikrein 1-related peptidase C2	Rattus norvegicus	26-31
12044607-8	2002	Our data suggest that tonin may be an alternative pathway to Ang II generation in the brain and could participate in the physiological effects exerted by Ang II such as water and saline intake and blood pressure elevation.	Water	169-174	kallikrein 1-related peptidase C2	Rattus norvegicus	22-27
12000273-1	2002	[reaction: see text] Nanometer tin-mediated allylation of aldehydes or ketones in distilled or tap water gave rise to corresponding homoallyl alcohol in high yield without any other assistance such as heat or supersonic or acidic media.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
11980488-9	2002	These results suggest that the proper organization of the hydrogen bond network within OEC for the water oxidation chemistry requires the Ca2+ ion and indicate that the role of Ca2+ is not purely structurally defined by the physical properties of the ion, such as valence and ionic radius.	Water	99-104	carbonic anhydrase 2	Homo sapiens	138-141
11980488-9	2002	These results suggest that the proper organization of the hydrogen bond network within OEC for the water oxidation chemistry requires the Ca2+ ion and indicate that the role of Ca2+ is not purely structurally defined by the physical properties of the ion, such as valence and ionic radius.	Water	99-104	carbonic anhydrase 2	Homo sapiens	177-180
11980488-10	2002	On the basis of these and other findings, we propose that Ca2+ is necessary for the formation of the hydrogen bond network that is involved in the reaction step of water oxidation.	Water	164-169	carbonic anhydrase 2	Homo sapiens	58-61
12009951-3	2002	In the present study, we have evaluated if the bombesin analogue [N(alpha)-histidinyl acetate]bombesin(7-14), radiolabeled with the novel [99mTc(OH(2))(3)(CO)(3)]+, has the potential to be used as a diagnostic radiopharmaceutical.	Water	145-151	gastrin releasing peptide	Homo sapiens	47-55
12016150-0	2002	Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice.	Water	44-49	Harvey rat sarcoma virus oncogene	Mus musculus	76-82
11827973-0	2002	Lack of the small plastid-encoded PsbJ polypeptide results in a defective water-splitting apparatus of photosystem II, reduced photosystem I levels, and hypersensitivity to light.	Water	74-79	photosystem II reaction center subunit X	Nicotiana tabacum	34-38
11827973-7	2002	Our results suggest a role of PsbJ for the stable assembly of the water-splitting complex of photosystem II and, in addition, support a control of photosystem I accumulation through photosystem II activity.	Water	66-71	photosystem II reaction center subunit X	Nicotiana tabacum	30-34
11931710-0	2002	Effect of semi-synthesized quercetin water-soluble derivatives on recombinant human phosphatidylinositol 3-kinase p110beta catalytic subunit.	Water	37-42	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	84-113
11931710-0	2002	Effect of semi-synthesized quercetin water-soluble derivatives on recombinant human phosphatidylinositol 3-kinase p110beta catalytic subunit.	Water	37-42	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	114-122
11974735-0	2002	Can tap water be used to irrigate wounds in A&amp;E?	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
11974735-1	2002	After critiquing the seven selected articles, it seems likely that tap water can be used as an irrigant and cleansing agent for soft-tissue wounds.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
11974735-2	2002	However, the current research on tap water has involved human and rat wound studies and tap water culture studies (Dire, 1990; Riyat and Quinton, 1997; Moscati, 1998).	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
11974735-2	2002	However, the current research on tap water has involved human and rat wound studies and tap water culture studies (Dire, 1990; Riyat and Quinton, 1997; Moscati, 1998).	Water	92-97	nuclear RNA export factor 1	Homo sapiens	33-36
11974735-5	2002	Two key conclusions could be drawn from the available research: The tap water tested was generally agreed to be safe from harmful bacteria and had no contaminating bacteria; Human and rat models showed a clear benefit in using tap water to cleanse soft tissue wounds, thus concluding tap water is safe for use on wounds (Towler, 2000).	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
11974735-5	2002	Two key conclusions could be drawn from the available research: The tap water tested was generally agreed to be safe from harmful bacteria and had no contaminating bacteria; Human and rat models showed a clear benefit in using tap water to cleanse soft tissue wounds, thus concluding tap water is safe for use on wounds (Towler, 2000).	Water	231-236	nuclear RNA export factor 1	Homo sapiens	68-71
11974735-5	2002	Two key conclusions could be drawn from the available research: The tap water tested was generally agreed to be safe from harmful bacteria and had no contaminating bacteria; Human and rat models showed a clear benefit in using tap water to cleanse soft tissue wounds, thus concluding tap water is safe for use on wounds (Towler, 2000).	Water	231-236	nuclear RNA export factor 1	Homo sapiens	68-71
11974735-6	2002	The financial benefits were also stated in the studies; tap water can have huge cost-saving potential for A&amp;E departments.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
12012198-1	2002	A rapid and simple method for separation and determination of tributyltin (TBT) in mineral and tap water is described.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	95-98
11919508-10	2002	Aquaporin 4 may also play a role in pathophysiologic conditions, as shown by the reduced edema formation observed after water intoxication and focal cerebral ischemia in AQP4-knockout mice.	Water	120-125	aquaporin 4	Mus musculus	0-11
11883945-2	2002	Preproapelin and APJ mRNA are found in hypothalamic regions known to be important in the regulation of food and water intake, and pituitary hormone release.	Water	112-117	apelin receptor	Rattus norvegicus	17-20
11883945-3	2002	The effects of intracerebroventricular (ICV) administration of pyroglutamylated apelin-13 on food and water intake and pituitary hormone release in rats were investigated.	Water	102-107	apelin	Rattus norvegicus	80-86
11883945-4	2002	Apelin-13 had little effect on food intake, but dose-dependently increased drinking behaviour and water intake at 1 h. Apelin-13 (10 nmol) increased water intake by up to sixfold compared to saline.	Water	98-103	apelin	Rattus norvegicus	0-6
11883945-4	2002	Apelin-13 had little effect on food intake, but dose-dependently increased drinking behaviour and water intake at 1 h. Apelin-13 (10 nmol) increased water intake by up to sixfold compared to saline.	Water	149-154	apelin	Rattus norvegicus	119-125
11883945-7	2002	These results suggest that apelin may play an important role in the hypothalamic regulation of water intake and endocrine axes.	Water	95-100	apelin	Rattus norvegicus	27-33
18968537-0	2002	Development of tyrosinase biosensor based on pH-sensitive field-effect transistors for phenols determination in water solutions.	Water	112-117	tyrosinase	Homo sapiens	15-25
11890849-2	2002	Recent investigations showed that orthogonal arrays were composed of aquaporin 4 (AQP4) molecules, a member of the water channel protein family.	Water	115-120	aquaporin 4	Homo sapiens	69-80
11890849-2	2002	Recent investigations showed that orthogonal arrays were composed of aquaporin 4 (AQP4) molecules, a member of the water channel protein family.	Water	115-120	aquaporin 4	Homo sapiens	82-86
11891887-2	2002	The substituent constant has been determined from the pK value of a fullerene-based, para-substituted benzoic acid 1 in 80% dioxane/water (v/v) by NMR spectroscopy.	Water	132-137	mediator complex subunit 25	Homo sapiens	110-116
11886195-3	2002	A strain of S. paucimobilis identical to one of the patient"s was isolated from tap water collected in the haematological unit.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
11939716-5	2002	The radioscanning of the samples prepared from the culture medium and the apical epithelial membranes subjected to SDS-PAGE and western blotting disclosed that the released, water soluble 97kDa MBP glycopeptide was labeled with proline and palmitate.	Water	174-179	myelin basic protein	Rattus norvegicus	194-197
11885352-6	2002	The electrolyte release of chlorine from the dental unit tap water by anodic oxidation without addition of any chemical disinfectant also resulted in continuously low colony numbers of the water.	Water	61-66	nuclear RNA export factor 1	Homo sapiens	57-60
11796780-1	2002	Aquaporin-4 (AQP4) is a highly conserved water channel protein.	Water	41-46	aquaporin 4	Homo sapiens	0-11
11796780-1	2002	Aquaporin-4 (AQP4) is a highly conserved water channel protein.	Water	41-46	aquaporin 4	Homo sapiens	13-17
12325458-1	2002	Deep sea water intake improves skin symptoms and mineral imbalance and decreases serum IgE levels mad IgE-inducing cytokines, IL-4, IL-13 and IL-18 in patients with atopic eczema/dermatitis syndrome (AEDS), while distilled water intake fails to do so.	Water	9-14	interleukin 18	Homo sapiens	142-147
12541622-8	2002	The method was used for the determination of trace chrysene in tap water, mineral water, rain water and river water.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
11804734-5	2001	Different deuterium ESEEM patterns for W95C and W16C (surface residue) indicate differences in the local water concentration, or accessibility, of the spin label by deuterium.	Water	105-110	spindlin 1	Homo sapiens	151-155
11748259-5	2001	In the presence of the substrates hydrogen peroxide (H(2)O(2)) and NO(2)(-), cell and vessel wall-associated MPO catalyzed nitration of ECM protein tyrosine residues, with fibronectin identified as a major target protein.	Water	53-58	myeloperoxidase	Mus musculus	109-112
11717465-1	2001	The Aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular astrocyte endfeet where it is concentrated.	Water	23-28	aquaporin 4	Mus musculus	4-15
11717465-1	2001	The Aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular astrocyte endfeet where it is concentrated.	Water	23-28	aquaporin 4	Mus musculus	17-21
11717465-1	2001	The Aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular astrocyte endfeet where it is concentrated.	Water	58-63	aquaporin 4	Mus musculus	4-15
11717465-1	2001	The Aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular astrocyte endfeet where it is concentrated.	Water	58-63	aquaporin 4	Mus musculus	17-21
11758754-11	2001	The water diffusivity was reduced proportionately to the concentration of RIM, and analysis indicated that about 150 g of water moved as a kinetic unit with each gram of mucin.	Water	4-9	solute carrier family 13 member 2	Rattus norvegicus	170-175
11758754-11	2001	The water diffusivity was reduced proportionately to the concentration of RIM, and analysis indicated that about 150 g of water moved as a kinetic unit with each gram of mucin.	Water	122-127	solute carrier family 13 member 2	Rattus norvegicus	170-175
11746601-2	2001	Xenopus oocytes injected with cRNA encoding C. albicans Aqy1p displayed a coefficient of water permeability (P(f)) that was equivalent to the P(f) for oocytes injected with the cRNA of S. cerevisiae Aqy1p.	Water	89-94	Aqy1p	Saccharomyces cerevisiae S288C	56-61
11580285-8	2001	We therefore conclude that A(24) has sufficient alpha-helical propensity, but insufficient hydrophobicity, to maintain a stable transmembrane association with phospholipid bilayers in the presence of water.	Water	200-205	immunoglobulin kappa variable 2-23 (pseudogene)	Homo sapiens	27-32
11665386-0	2001	"Captain of the ship" doctrine continues to take on water.	Water	52-57	inositol polyphosphate-5-phosphatase D	Homo sapiens	16-20
11547116-10	2001	Due to the elevated sodium content in softened tap water families should be alerted to use untreated tap water for preparing enemas.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
11547116-10	2001	Due to the elevated sodium content in softened tap water families should be alerted to use untreated tap water for preparing enemas.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	101-104
11568317-1	2001	PURPOSE: To determine whether the evolution of the core apparent diffusion coefficient (ADC) of water in ischemic stroke varies with patient age or infarct etiology.	Water	96-101	antizyme inhibitor 2	Rattus norvegicus	88-91
11686389-4	2001	A simple technique was used to detect, observe, and evaluate the concentration of free-living amoebae in dental unit and tap water samples.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	121-124
11845090-9	2001	Tap water usage for food follows a normal distribution (arithmetic mean in winter=1.55 l/j, 95% CI [0.20-2.90]; arithmetic mean in spring=1.78 l/j, [0.13-3.43]).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
11845090-11	2001	Tap water intake amounts to more than 80% of total drinking water consumption, and pure tap water (i.e not added, modified nor boiled) amounts to 42% of total drinking water.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
11603856-2	2001	After bottling, the autochthonous microflora reached 6 x 10(5) cfu ml(-1) after a 5-day incubation period in tap water unfiltered and which was non-autoclaved.	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
11603856-7	2001	All strains were able to grow in tap water samples, which were filtered and autoclaved, and a final concentration of 10(5)-10(6) cfu ml(-1) was observed.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
11603856-8	2001	Any inherent capability of Aeromonas to grow in tap water was eliminated by the presence of autochthonous microflora and "ultramicrocells" bacteria.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
11788870-2	2001	Glucose-6-phosphate dehydrogenase (G6PDH) was freeze-dried in 10% (w/v) dextrans of five molecular weights (12 kD, 42 kD, 71 kD, 512 kD and 2000 kD) to residual water content of 0.027 ( 0.004 g/g dry mass.	Water	161-166	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
11788870-2	2001	Glucose-6-phosphate dehydrogenase (G6PDH) was freeze-dried in 10% (w/v) dextrans of five molecular weights (12 kD, 42 kD, 71 kD, 512 kD and 2000 kD) to residual water content of 0.027 ( 0.004 g/g dry mass.	Water	161-166	glucose-6-phosphate dehydrogenase	Homo sapiens	35-40
11554252-5	2001	An additional parameter has been added representing the initial velocity of the water column at slug initiation and is incorporated into an analytical solution to generate the first time step before a sequential numerical solution generates the remainder of the time solution.	Water	80-85	snail family transcriptional repressor 2	Homo sapiens	96-100
11518772-1	2001	Aquaporin-4 (AQP4) is a member of the aquaporin water-channel family.	Water	48-53	aquaporin 4	Mus musculus	0-11
11518772-1	2001	Aquaporin-4 (AQP4) is a member of the aquaporin water-channel family.	Water	48-53	aquaporin 4	Mus musculus	13-17
11668730-1	2001	Despite the fact that the ADA had set the goal of less than 200 colony-forming units per milliliter of unfiltered output water from dental unit waterlines to be achieved voluntarily by the year 2000, there is much confusion and resistance within the profession with regard to waterlines.	Water	121-126	adenosine deaminase	Homo sapiens	26-29
11676192-11	2001	Actually the aquaporin-4 water channel has been found to colocalize with Kir4.1 in retinal glial cells.	Water	25-30	aquaporin 4	Homo sapiens	13-24
11487122-0	2001	Improved AOX degradation in UV oxidative waste water treatment by dialysis with nanofiltration membrane.	Water	47-52	acyl-CoA oxidase 1	Homo sapiens	9-12
11468389-3	2001	Differences in the orientation of thyroxine and the position of water molecules in the two binding sites further suggest a mechanism for the docking pathway of the hormone into the channel of TTR.	Water	64-69	transthyretin	Rattus norvegicus	192-195
11565849-0	2001	A theoretical study of the cis-syn pyrimidine dimers in the gas phase and water cluster and a tautomer-bypass mechanism for the origin of UV-induced mutations.	Water	74-79	synemin	Homo sapiens	31-34
11476237-9	2001	The method is demonstrated with deionized and tap water samples spiked with carbamate insecticides.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
11425306-11	2001	Comparison to a structure of rabbit PGI with 5PAA bound indicates that ring opening is followed by loss of the protonated water molecule and conformational changes in the substrate and the protein so that a helix containing amino acids 513-520 moves in toward the substrate to form additional hydrogen bonds with the substrate.	Water	122-127	glucose-6-phosphate isomerase	Oryctolagus cuniculus	36-39
11519974-9	2001	CONCLUSION: The comparison of these data with other surveys points to a low total water intake, especially a low tap water intake, in German children and adolescents and underlines cultural influences on food and drinking habits.	Water	117-122	nuclear RNA export factor 1	Homo sapiens	113-116
11401827-2	2001	In the principal cells of the kidney collecting duct, water reabsorption is mediated by the combined action of AQP2 in the apical membrane and both AQP3 and AQP4 in the basolateral membrane, and the expression of AQP2 and AQP3 is regulated by antidiuretic hormone and water restriction.	Water	54-59	aquaporin 4	Canis lupus familiaris	157-161
11416031-8	2001	Salt-loading (1% NaCl in drinking water) increased uroguanylin-mRNA expression by &gt;1.8-fold but had no effect on guanylin expression.	Water	34-39	guanylate cyclase activator 2a (guanylin)	Mus musculus	54-62
11339937-5	2001	The use of alpha-amylase (EC 3.2.1.1) to modify porosity and surface properties of starch resulted in materials with enhanced water sorption properties compared to the native material.	Water	126-131	alpha-amylase	Zea mays	11-24
11382287-11	2001	For example, tap water samples were analyzed directly while a short degassing of mineral water (to prevent bubble formation during the separation) and filtration of river water samples (to remove particulates and colloids) were the only operations needed in this respect.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
11427334-1	2001	To determine pharmacological specificity of intracerebroventricular (IVT) administration of adrenomedullin (AM) on water and sodium excretion, studies were performed in rats pretreated with AM (22-52), a putative AM-receptor antagonist or CGRP(8-37), a ligand that preferentially antagonizes the CGRP(1)-receptor subtype.	Water	115-120	adrenomedullin	Rattus norvegicus	92-106
11424725-1	2001	Energy consumption in sewage treatment facilities in Japan has increased due to increasing tap water consumption.	Water	95-100	nuclear RNA export factor 1	Homo sapiens	91-94
11347730-4	2001	Results show that clinically desirable uniformity and penetration of SAR can be obtained for square apertures in the range of 4-6 cm per side at 433 MHz, using 9.5-12.5 mm thick water coupling boluses, as compared to the optimum 2-4.5 cm square apertures and 5-10 mm water bolus dimensions determined previously for 915 MHz arrays.	Water	178-183	sarcosine dehydrogenase	Homo sapiens	69-72
11347730-4	2001	Results show that clinically desirable uniformity and penetration of SAR can be obtained for square apertures in the range of 4-6 cm per side at 433 MHz, using 9.5-12.5 mm thick water coupling boluses, as compared to the optimum 2-4.5 cm square apertures and 5-10 mm water bolus dimensions determined previously for 915 MHz arrays.	Water	267-272	sarcosine dehydrogenase	Homo sapiens	69-72
11429159-2	2001	Recently, chicken IFN-alpha (ChIFN-alpha) has been identified and shown to ameliorate Newcastle disease virus (NDV) infection when given to chickens at relatively high concentrations in the drinking water.	Water	199-204	interferon	Gallus gallus	18-27
11278590-4	2001	Presumably, colipase functions by anchoring and orienting PTL at the oil-water interface.	Water	73-78	pancreatic lipase	Homo sapiens	58-61
11472131-1	2001	Oxidation of the surface of cross-linked 1,4-polybutadiene provided a hydrophilic substrate that reconstructed against hot water to become more hydrophobic.	Water	123-128	alcohol dehydrogenase iron containing 1	Homo sapiens	119-122
11170215-1	2001	Multiple molecular dynamics (MD) simulations of fully solvated rat intestinal fatty acid binding protein (I-FABP) were conducted to investigate the dynamics of internal water molecules.	Water	169-174	fatty acid binding protein 2	Rattus norvegicus	106-112
11170215-2	2001	Although the long time average of the number of internal water molecules in I-FABP is 22 as shown by the X-ray crystal structure, MD simulations predict large variations in the instantaneous number of internal water molecules on the nanosecond time scale.	Water	57-62	fatty acid binding protein 2	Rattus norvegicus	76-82
11170215-5	2001	Exchange of internal water in I-FABP appears to occur almost exclusively through the interface of beta-strands EF with the rest of the protein, which has significant implications for the pathways of the fatty acid entry and exit from the binding cavity.	Water	21-26	fatty acid binding protein 2	Rattus norvegicus	30-36
11318912-1	2001	OBJECTIVES: Because of growing concern that constituents of drinking water may have adverse health effects, consumption of tap water in North America has decreased and consumption of bottled water has increased.	Water	69-74	nuclear RNA export factor 1	Homo sapiens	123-126
11318912-1	2001	OBJECTIVES: Because of growing concern that constituents of drinking water may have adverse health effects, consumption of tap water in North America has decreased and consumption of bottled water has increased.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
11318912-1	2001	OBJECTIVES: Because of growing concern that constituents of drinking water may have adverse health effects, consumption of tap water in North America has decreased and consumption of bottled water has increased.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
11318912-2	2001	Our objectives were to 1) determine whether North American tap water contains clinically important levels of calcium (Ca2+), magnesium (Mg2+), and sodium (Na+) and 2) determine whether differences in mineral content of tap water and commercially available bottled waters are clinically important.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
11207149-6	2001	Adjustment for identified risk factors for anencephaly did not substantially alter these associations, nor did control for maternal dietary nitrate, total vitamin C intake, and quantity of tap water consumed.	Water	193-198	nuclear RNA export factor 1	Homo sapiens	189-192
11327810-8	2001	NOESY spectra of 1 and 2 recorded in 95% H(2)O, 5% D(2)O indicated that the imino proton of the base opposite N14, G5, or T5, formed a weak hydrogen bond with N14.	Water	41-46	SS nuclear autoantigen 1	Homo sapiens	110-113
11327810-8	2001	NOESY spectra of 1 and 2 recorded in 95% H(2)O, 5% D(2)O indicated that the imino proton of the base opposite N14, G5, or T5, formed a weak hydrogen bond with N14.	Water	41-46	SS nuclear autoantigen 1	Homo sapiens	159-162
11327835-1	2001	Histidine 64 in human carbonic anhydrase II (HCA II) functions in the catalytic pathway of CO(2) hydration as a shuttle to transfer protons between the zinc-bound water and bulk water.	Water	163-168	carbonic anhydrase 2	Homo sapiens	22-43
11327835-1	2001	Histidine 64 in human carbonic anhydrase II (HCA II) functions in the catalytic pathway of CO(2) hydration as a shuttle to transfer protons between the zinc-bound water and bulk water.	Water	178-183	carbonic anhydrase 2	Homo sapiens	22-43
11798865-7	2001	RESULTS: The c-fos AS ODN blocked the c-fos gene expression and reduced the content of both water and sodium in brain tissue and Ca(2+) in symptosome, thus alleviating the morphological damage in neuron.	Water	92-97	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
11258813-6	2001	The ratio of DOC to TFP (C:P) influenced the fate of PO4 in the water, implying that DOC was forming complexes with phosphorus.	Water	64-69	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	20-23
11166409-2	2001	The role of molecular weight and glass transition in the mechanism of water-induced volume expansion and drug release of PDLA tablets was investigated.	Water	70-75	PDON2	Homo sapiens	121-125
11166409-6	2001	At 95% relative humidity all molecular weight grades of PDLA sorbed 1.1-1.3% w/w water, as was determined with DVS.	Water	81-86	PDON2	Homo sapiens	56-60
11166409-11	2001	It is concluded that volume expansion of compressed PDLA tablets is related to the glass transition behaviour, originates from water-induced and thermally stimulated shape memory behaviour and is therefore highly dependent on the molecular weight of PDLA.	Water	127-132	PDON2	Homo sapiens	52-56
11166409-11	2001	It is concluded that volume expansion of compressed PDLA tablets is related to the glass transition behaviour, originates from water-induced and thermally stimulated shape memory behaviour and is therefore highly dependent on the molecular weight of PDLA.	Water	127-132	PDON2	Homo sapiens	250-254
11291204-7	2001	The GAB model fitted the sorption data at all conditions and over the entire range of water activity studied.	Water	86-91	alpha-1-B glycoprotein	Homo sapiens	4-7
11234387-1	2001	The interaction between carbonic anhydrase B in the molten globule state and water molecules was studied by high-resolution NMR spectroscopy.	Water	77-82	carbonic anhydrase 2	Homo sapiens	24-44
11234387-3	2001	This is a process of complex bioexponential kinetics presented in spin diffusion spectra as a change in water signal intensity dependent on the post-excitation time of protein molecules.	Water	104-109	spindlin 1	Homo sapiens	66-70
11719004-9	2001	The coexpression of MCT2 and aquaporin 4 suggests a possible role for MCT2 in regulating transcellular water movement.	Water	103-108	aquaporin 4	Homo sapiens	29-40
11124031-2	2000	The three-dimensional crystal structure of the CAP-cAMP complex has been refined at 2.1 A resolution, thus enabling a better evaluation of the structural basis for CAP phenotypes, the interactions of cAMP with CAP and the roles played by water structure.	Water	238-243	catabolite gene activator protein	Escherichia coli	47-50
11138133-1	2000	We mapped the water and amphiphilic molecules by Ising spin variables for S=1.	Water	14-19	spindlin 1	Homo sapiens	55-59
11138133-2	2000	The zero component of spin represents the water molecules, while the remaining components (+/-1) account for the amphiphilic molecules.	Water	42-47	spindlin 1	Homo sapiens	22-26
11062334-1	2000	Guanylin (GN) and uroguanylin (UGN) are two recently identified peptides that have been shown to affect water and electrolyte transport in both the intestine and the kidney.	Water	104-109	guanylate cyclase activator 2A	Rattus norvegicus	0-8
11062334-1	2000	Guanylin (GN) and uroguanylin (UGN) are two recently identified peptides that have been shown to affect water and electrolyte transport in both the intestine and the kidney.	Water	104-109	guanylate cyclase activator 2A	Rattus norvegicus	10-12
11084289-7	2000	Upon dilution with water the alkoxyl group was substituted by water, giving the respective hydroxyl adduct of the spin trap.	Water	19-24	spindlin 1	Homo sapiens	114-118
11084289-7	2000	Upon dilution with water the alkoxyl group was substituted by water, giving the respective hydroxyl adduct of the spin trap.	Water	62-67	spindlin 1	Homo sapiens	114-118
11093645-10	2000	Application was illustrated by the analysis of water samples collected from tap water, ground water and farm water in the southern Taichung area.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	76-79
11017751-3	2000	However, the activation energies of desorption for chemisorbed water varied from approximately 80 to &gt;247 kJ/mol for fumed silica, Cab-O-Sil-M-7D, and approximately 96 to 155 kJ/mol for precipitated silica, Hi-Sil-233.	Water	63-68	neural proliferation, differentiation and control 1	Homo sapiens	134-137
11017751-6	2000	Most of the chemisorbed water with activation energies &lt;126 kJ/mol can be pumped away in a matter of days in a good vacuum environment at 500 K. We had previously measured about 0.1-0.4 wt% of water in silica-reinforced polysiloxane formulations containing approximately 21% Cab-O-Sil-M-7D and approximately 4% Hi-Sil-233.	Water	24-29	neural proliferation, differentiation and control 1	Homo sapiens	278-281
11017751-6	2000	Most of the chemisorbed water with activation energies &lt;126 kJ/mol can be pumped away in a matter of days in a good vacuum environment at 500 K. We had previously measured about 0.1-0.4 wt% of water in silica-reinforced polysiloxane formulations containing approximately 21% Cab-O-Sil-M-7D and approximately 4% Hi-Sil-233.	Water	196-201	neural proliferation, differentiation and control 1	Homo sapiens	278-281
11027658-9	2000	The presence of AQP7 in the proximal tubule brush border indicates a role of AQP7 in proximal tubule water reabsorption.	Water	101-106	aquaporin 7	Rattus norvegicus	16-20
11027658-9	2000	The presence of AQP7 in the proximal tubule brush border indicates a role of AQP7 in proximal tubule water reabsorption.	Water	101-106	aquaporin 7	Rattus norvegicus	77-81
11015219-4	2000	The second, low-occupancy form consists of a hCAII-cyanamide-water ternary complex where the catalytic zinc ion, still being bound to cyanamide, is approached by a water molecule in a five-coordinate adduct.	Water	61-66	carbonic anhydrase 2	Homo sapiens	45-50
11015219-4	2000	The second, low-occupancy form consists of a hCAII-cyanamide-water ternary complex where the catalytic zinc ion, still being bound to cyanamide, is approached by a water molecule in a five-coordinate adduct.	Water	164-169	carbonic anhydrase 2	Homo sapiens	45-50
11033414-1	2000	Oxidation of 1-O-hexadec-1"-enyl-arachidonoyl glycerophosphocholine (16:0p/20:4-GPC) by hydroxyl radical generated from Cu(II)/H(2)O(2) was found to yield major products corresponding to free carboxylic acids of 5-hydroxyeicosatetraenoic acid and several 5, 12-dihydroxyeicosatetraenoic acid.	Water	127-132	glycophorin C (Gerbich blood group)	Homo sapiens	80-83
11052716-1	2000	In 1997 this laboratory initiated a research program with the objective of examining the effect that rinsing of produce with tap water would have on pesticide residues.	Water	129-134	nuclear RNA export factor 1	Homo sapiens	125-128
11052716-8	2000	One subsample was processed unwashed, whereas the other was rinsed under tap water.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
11254039-10	2000	Assays apparently determined by the water matrix, contributed to Factor 2 and explained 20% of the variation within the data.	Water	36-41	transcription termination factor 2	Homo sapiens	65-73
10988134-6	2000	This was demonstrated by lower wet-to-dry lung weight ratios and less lung water accumulation in the KGF group.	Water	75-80	fibroblast growth factor 7	Rattus norvegicus	101-104
10974049-0	2000	Dynamic interfacial properties of human apolipoproteins A-IV and B-17 at the air/water and oil/water interface.	Water	81-86	NADH:ubiquinone oxidoreductase subunit B6	Homo sapiens	40-69
10974049-0	2000	Dynamic interfacial properties of human apolipoproteins A-IV and B-17 at the air/water and oil/water interface.	Water	95-100	NADH:ubiquinone oxidoreductase subunit B6	Homo sapiens	40-69
10946229-4	2000	Crystal structures of AAG complexed to DNA suggest that the enzyme selects substrate bases through a combination of hydrogen bonding and the steric constraints of the active site, and that the enzyme activates a water molecule for an in-line backside attack of the N-glycosylic bond.	Water	212-217	N-methylpurine DNA glycosylase	Homo sapiens	22-25
10967554-1	2000	The rapid effect of 1 alpha,25(OH(2))-vitamin D(3) [1 alpha, 25(OH(2))D(3)] on tyrosine kinase Src and its relationship to the vitamin D receptor (VDR) was investigated to further characterize the hormone signaling mechanism in chick muscle cells.	Water	31-37	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	95-98
10981483-4	2000	Sometimes the tap water showed very high aluminum content that does not permit the water treatment system to efficiently remove all the aluminum, forcing the use of water treatment systems with a double reverse-osmosis filter on line.	Water	18-23	nuclear RNA export factor 1	Homo sapiens	14-17
10924044-2	2000	We previously demonstrated that H(2)O(2) opens the large-conductance, calcium- and voltage-activated (BK(Ca)) potassium channel of coronary myocytes (2) and now report physiological and biochemical evidence that the effect of H(2)O(2) on coronary smooth muscle involves the phospholipase A(2) (PLA(2))/arachidonic acid (AA) signaling cascades.	Water	32-37	phospholipase A2 group IIA	Homo sapiens	294-299
10924044-2	2000	We previously demonstrated that H(2)O(2) opens the large-conductance, calcium- and voltage-activated (BK(Ca)) potassium channel of coronary myocytes (2) and now report physiological and biochemical evidence that the effect of H(2)O(2) on coronary smooth muscle involves the phospholipase A(2) (PLA(2))/arachidonic acid (AA) signaling cascades.	Water	226-231	phospholipase A2 group IIA	Homo sapiens	294-299
11036787-7	2000	The use of tap water instead of spring water may be helpful to improve the efficacy of drug treatment via drinking water.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
10973152-4	2000	RESULTS/CONCLUSIONS: The results of the adjusted model showed that the proportion of households without tap water was the variable that contributed the most to the increasing fluctuation of cholera incidence rates.	Water	108-113	nuclear RNA export factor 1	Homo sapiens	104-107
10896887-6	2000	At the two higher doses, ANG II stimulated more water intake with a shorter latency to drink in rats with NTS-X than in control rats.	Water	48-53	angiogenin	Rattus norvegicus	25-28
10870101-3	2000	AQY1 has been shown to encode a functional water channel but only in certain laboratory strains.	Water	43-48	Aqy1p	Saccharomyces cerevisiae S288C	0-4
11860936-9	2000	The positive detection rates (&gt; 50 pg/ml) of microcystin in well, tap-water, river and pond water were 0.00%, 0.00%, 36.23% and 17.14% respectively.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
10926225-3	2000	4H2O or Ni(ClO4)2.6H2O to give the multinuclear nickel(II) complexes [Ni(H-1-Imin)(OAc)]2 (2) (which contains a coordinated Schiff base obtained by reation of the primary amine with the acetone solvent) and [Ni3(H3-1)(H2-1)2]-ClO4.H2O.3 MeCN (3), respectively.	Water	1-4	A-kinase anchoring protein 5	Homo sapiens	218-222
11256708-6	2000	In deionized water and a sample of chlorinated tap water, systematic biases relative to strict adherence to Method 552 were precise and could be corrected for using similarly treated standards and analyte-fortified (spiked) samples.	Water	51-56	nuclear RNA export factor 1	Homo sapiens	47-50
10814534-7	2000	Induction of apoptosis by H(2)O(2) and its inhibition by antisense c-jun was confirmed by detection of internucleosomal fragmentation of DNA, TdT-mediated dUTP nick end labeling (TUNEL)-positive cells and morphological alteration of nuclei.	Water	26-32	DNA nucleotidylexotransferase	Homo sapiens	142-145
10799289-3	2000	Here we show that a polypeptide encompassing the C-terminal cluster of basic amino acids of netrin-1 (i) adopts an alpha-helical conformation in water-trifluoroethanol mixtures according to circular dichroism experiments and (ii) binds electrostatically to heparin with high affinity under physiological ionic conditions (K(D) = 15 nM for the binding to immobilized heparin according to surface plasmon resonance, K(D) = 50 nM in solution as determined with isothermal titration calorimetry).	Water	145-150	netrin 1	Homo sapiens	92-100
10781416-6	2000	Osmotically driven water permeability between the air space and capillary compartments is reduced approximately 10-fold by deletion of AQP1 or AQP5 and reduced even more by deletion of AQP1 and AQP4 or AQP1 and AQP5 together.	Water	19-24	aquaporin 5	Mus musculus	143-147
10781416-6	2000	Osmotically driven water permeability between the air space and capillary compartments is reduced approximately 10-fold by deletion of AQP1 or AQP5 and reduced even more by deletion of AQP1 and AQP4 or AQP1 and AQP5 together.	Water	19-24	aquaporin 4	Mus musculus	194-198
10781416-6	2000	Osmotically driven water permeability between the air space and capillary compartments is reduced approximately 10-fold by deletion of AQP1 or AQP5 and reduced even more by deletion of AQP1 and AQP4 or AQP1 and AQP5 together.	Water	19-24	aquaporin 5	Mus musculus	211-215
10870513-2	2000	Recent experiments indicate that water movement through AQP5 in the salivary gland is important in saliva secretion.	Water	33-38	aquaporin 5	Mus musculus	56-60
11428118-5	2000	Crystallization of 1-OTf in the presence of water affords a colorless high-spin complex, Fe(Me3tacn)(H2O)(CF3-SO3)2 (4), that exists as a pair of molecules bridged by hydrogen bonds between the coordinated water and the two bound triflate anions of the inversion-related partner.	Water	44-49	spindlin 1	Homo sapiens	75-79
11428118-5	2000	Crystallization of 1-OTf in the presence of water affords a colorless high-spin complex, Fe(Me3tacn)(H2O)(CF3-SO3)2 (4), that exists as a pair of molecules bridged by hydrogen bonds between the coordinated water and the two bound triflate anions of the inversion-related partner.	Water	101-104	spindlin 1	Homo sapiens	75-79
11428118-5	2000	Crystallization of 1-OTf in the presence of water affords a colorless high-spin complex, Fe(Me3tacn)(H2O)(CF3-SO3)2 (4), that exists as a pair of molecules bridged by hydrogen bonds between the coordinated water and the two bound triflate anions of the inversion-related partner.	Water	206-211	spindlin 1	Homo sapiens	75-79
10825806-4	2000	Fungal beta-1,3-glucans exhibit a variety of biological and immuno-pharmacological activities, and the significance of these activities is dependent on the structure, such as solubility in water, molecular weight, degree of branching, and conformation.	Water	189-194	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	7-15
10773159-1	2000	The Mn(4) complex which is involved in water oxidation in photosystem II is known to exhibit three types of EPR signals in the S(2) state, one of the five redox states of the enzyme cycle: a multiline signal (spin 1/2), signals at g5 (spin 5/2) and a signal at g=4.1 (or g=4.25).	Water	39-44	spindlin 1	Homo sapiens	209-217
10751559-3	2000	Injection of UCN into the ventromedial hypothalamic nucleus (VMH) significantly inhibited food and water intake over 3 h without sedative effect, but no significant effect was observed following injection either into the lateral hypothalamic area, or the paraventricular nucleus of the hypothalamus.	Water	99-104	urocortin	Rattus norvegicus	13-16
10751559-5	2000	Injection of anti-rat UCN rabbit gamma-globulin into the bilateral VMH in freely fed rats significantly potentiated food and water intake compared with rats that received normal rabbit gamma-globulin.	Water	125-130	urocortin	Oryctolagus cuniculus	22-25
10757164-3	2000	A major difference was observed in the initial CID product ions derived from lyso-GPC [M + H]+ with the loss of water that was very abundant for acyl lyso-GPC which have a fatty acid ester substituent at either the sn-1 or sn-2 positions.	Water	112-117	glycophorin C (Gerbich blood group)	Homo sapiens	82-85
10757164-3	2000	A major difference was observed in the initial CID product ions derived from lyso-GPC [M + H]+ with the loss of water that was very abundant for acyl lyso-GPC which have a fatty acid ester substituent at either the sn-1 or sn-2 positions.	Water	112-117	glycophorin C (Gerbich blood group)	Homo sapiens	155-158
10786005-1	2000	Water is effective in leaching out Cr6+ from a mixture of paint powders and abrasive blast media.	Water	0-5	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	35-38
10805445-3	2000	Functional analysis of LIMP 1 by expression in Xenopus laevis oocytes show that it is a water-specific aquaporin.	Water	88-93	LIMP1	Lotus japonicus	23-29
10897620-0	2000	[Does the changed Th1/Th2 activity in children with the assessment of body water in children with nephrotic syndrome: initial results].	Water	75-80	negative elongation factor complex member C/D	Homo sapiens	18-21
10722758-1	2000	Aquaporin-5 (AQP5) is a water channel protein expressed in lung, salivary gland, and lacrimal gland epithelia.	Water	24-29	aquaporin 5	Mus musculus	0-11
10716998-9	2000	Accordingly, H(2)O(2) and the glutathione-depleting drug buthionine sulfoximine increased to different extents CCR2, CCR5, and CXCR4 mRNA expression.	Water	13-18	C-C motif chemokine receptor 5	Homo sapiens	117-121
10716998-9	2000	Accordingly, H(2)O(2) and the glutathione-depleting drug buthionine sulfoximine increased to different extents CCR2, CCR5, and CXCR4 mRNA expression.	Water	13-18	C-X-C motif chemokine receptor 4	Homo sapiens	127-132
10712293-6	2000	In the central nucleus of the amygdala, naloxone administration to those rats drinking water significantly increased c-Fos-IR, an effect that was significantly enhanced by sucrose consumption, suggesting an upregulation of endogenous opioid tone in this area.	Water	87-92	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-122
10728111-0	2000	Fluoride and bacterial content of bottled water vs tap water.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
10728111-1	2000	CONTEXT: Bottled water has become a status symbol and is frequently used in place of tap water.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	85-88
10728111-1	2000	CONTEXT: Bottled water has become a status symbol and is frequently used in place of tap water.	Water	89-94	nuclear RNA export factor 1	Homo sapiens	85-88
10728111-17	2000	Recently, the Environmental Protection Agency, Washington, DC, published a final ruling that requires community water systems to regularly report to the public on the quality of local tap water; there are no similar proposals to determine the quality of bottled water through labeling.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	184-187
10795927-6	2000	Deletion of AQP1 or AQP5, water channels in lung endothelia and epithelia, resulted in a 90% decrease in airspace-capillary water permeability.	Water	26-31	aquaporin 5	Mus musculus	20-24
11272579-1	2000	This study consists of two parts: The first part comprised an experimental determination of the kinetic parameters for the exchange of water between UO2(H2O)5(2+) and bulk water, including an ab initio study at the SCF and MP2 levels of the geometry of UO2(H2O)5(2+), UO2(H2O)4(2+), and UO2(H2O)6(2+) and the thermodynamics of their reactions with water.	Water	135-140	KIT ligand	Homo sapiens	215-218
11225669-6	2000	The potential of AF4-TXRF coupling for the study of metal ion exchange equilibria with colloids was demonstrated by spiking seepage water with various heavy metals and subsequent AF4-TXRF analysis of the heavy metals bound to the colloidal fraction (Cu, Cr, Zn, Ni, Co).	Water	132-137	AF4/FMR2 family member 1	Homo sapiens	17-20
10662561-12	2000	Consumption of tap water in the hospital was commoner among affected staff members than among controls, but this did not reach significance (P = 0.1).	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
10655103-7	2000	These results implicate a key role for AQP4 in modulating brain water transport, and suggest that AQP4 inhibition may provide a new therapeutic option for reducing brain edema in a wide variety of cerebral disorders.	Water	64-69	aquaporin 4	Mus musculus	39-43
10961683-6	2000	Comparison of the effects of ethanol on Ca2+-induced structural transitions in DNA and polyphosphates in mixed solvents permits to suppose that at alcohol concentrations in solution resulting in disruption of the water spatial structure, some peculiarities are observed in the behavior of those molecules whose hydrophobic interactions are essential.	Water	213-218	carbonic anhydrase 2	Homo sapiens	40-43
10644652-6	2000	Several of the mammalian aquaporins (e.g., AQP1, AQP2, AQP4, and AQP5) appear to be highly selective for the passage of water, whereas others (recently termed aquaglyceroporins) also transport glycerol (e.g., AQP3 and AQP8) and even larger solutes (AQP9).	Water	120-125	aquaporin 4	Homo sapiens	55-59
10644654-1	2000	Physiological and pharmacological studies have demonstrated that extracellular ATP, acting through P2Y(2) purinoceptor, modulates water permeability of renal medullary collecting duct cells and the secretion of ions, mucin, and surfactant phospholipids by respiratory epithelia.	Water	130-135	purinergic receptor P2Y2	Rattus norvegicus	99-105
11790327-3	2000	The paradox was explained in part, by the presence in serum of purine nucleoside phosphorylase and adenosine deaminase, that, together with xanthine oxidase, catabolized adenosine, inosine, hypoxanthine, and xanthine to uric acid yielding trypanocidal H(2)O(2).	Water	252-257	adenosine deaminase	Homo sapiens	99-118
10614654-7	2000	These results imply that adrenal ANP may participate in the intraadrenal regulation of adrenal function on water-electrolyte homeostasis in an autocrine or paracrine manner.	Water	107-112	natriuretic peptide A	Rattus norvegicus	33-36
10694773-7	2000	RESULTS: Iodine in tap water varied from 2.1 to 30.2 microg/l; the iodine content was in general highest in the eastern part of Denmark and lowest in the western part of Denmark.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
11197480-5	2000	This mutant has been engineered with the aim of restricting water accessibility to the exposed heme edge of cytochrome b5.	Water	60-65	cytochrome b5 type A	Rattus norvegicus	108-121
10717374-9	2000	An estimated 17% of mothers lived in households with tap water lead concentrations of 10 microg/litre (the [WHO,] guideline) or above in 1993 compared with 49% in 1981.	Water	57-62	nuclear RNA export factor 1	Homo sapiens	53-56
10717374-13	2000	Nevertheless, between 63% and 76% of cases of mothers with blood lead concentrations of 10 microg/dl or above were attributable to tap water lead.	Water	135-140	nuclear RNA export factor 1	Homo sapiens	131-134
10717374-15	2000	About 15% of infants may be exposed via bottle feeds to tap water lead concentrations that exceed the WHO guideline of 10 microg/litre.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
10933910-3	2000	Infection in the presence of free cholesterol at its maximum solubility in water led to increased binding, uptake, and expression of Ad in human skin fibroblasts and alveolar macrophages, two primary human cells known to be deficient in CAR.	Water	75-80	CXADR Ig-like cell adhesion molecule	Homo sapiens	237-240
10704720-5	2000	We conclude that peptide YY decreases water and electrolyte secretion in the colonic mucosa by a complex neural mechanism involving at least two neurons connected through a nicotinic synapse, alpha-2 adrenoceptors and sigma receptors, and that this effect can occur with physiological doses of peptide YY.	Water	38-43	peptide YY	Rattus norvegicus	17-27
10916423-4	2000	The water channels aquaporin-3 (AQP3) and aquaporin-4 (AQP4), which are constitutively present in the basolateral membrane, allow the exit of water from the cell into the hypertonic interstitium.	Water	4-9	aquaporin 4	Homo sapiens	42-53
10916423-4	2000	The water channels aquaporin-3 (AQP3) and aquaporin-4 (AQP4), which are constitutively present in the basolateral membrane, allow the exit of water from the cell into the hypertonic interstitium.	Water	4-9	aquaporin 4	Homo sapiens	55-59
10916423-4	2000	The water channels aquaporin-3 (AQP3) and aquaporin-4 (AQP4), which are constitutively present in the basolateral membrane, allow the exit of water from the cell into the hypertonic interstitium.	Water	142-147	aquaporin 4	Homo sapiens	42-53
10916423-4	2000	The water channels aquaporin-3 (AQP3) and aquaporin-4 (AQP4), which are constitutively present in the basolateral membrane, allow the exit of water from the cell into the hypertonic interstitium.	Water	142-147	aquaporin 4	Homo sapiens	55-59
10669294-4	1999	Sample capacity was investigated by injecting large volumes (up to 6 ml) using a high total hardness and chloride tap water.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
10669294-10	1999	Reproducibilities in tap water were 18% (5 microg l(-1), n=12) and 21% (1 microg l(-1), n=4) respectively for 1.5 and 6 ml injection volumes with conductivity detection, and 17% at 0.5 microg l(-1) (n=9) with spectrophotometric detection.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
10656665-0	1999	Experimental evidence for the presence of a water network at the peptide-MHC interface.	Water	44-49	major histocompatibility complex, class I, C	Homo sapiens	73-76
10586940-2	1999	METHODS: EAU was induced by immunization with bovine interphotoreceptor retinal binding protein (IRBP) in Freund"s complete adjuvant (subcutaneous injection) and pertussis toxin (intraperitoneal injection) in B10RIII mouse.	Water	9-12	retinol binding protein 3	Bos taurus	53-95
10586940-2	1999	METHODS: EAU was induced by immunization with bovine interphotoreceptor retinal binding protein (IRBP) in Freund"s complete adjuvant (subcutaneous injection) and pertussis toxin (intraperitoneal injection) in B10RIII mouse.	Water	9-12	retinol binding protein 3	Bos taurus	97-101
10581548-3	1999	The structures of these complexes demonstrate that water molecules are critical to switch the active site of CK2 from an ATP- to a GTP-compatible state.	Water	51-56	Calcium-dependent protein kinase 6	Zea mays	109-112
10556361-10	1999	An uncoupled antiport mechanism, driven by a proton gradient rather than ATP, can explain low selectivity in the SMR multidrug carriers of bacteria, and a half-coupled mechanism for the ion-driven cotransport of water (the substrate in which the carrier site is immersed) can explain a recently proposed uphill flow of water.	Water	212-217	LY6/PLAUR domain containing 4	Homo sapiens	113-116
10556361-10	1999	An uncoupled antiport mechanism, driven by a proton gradient rather than ATP, can explain low selectivity in the SMR multidrug carriers of bacteria, and a half-coupled mechanism for the ion-driven cotransport of water (the substrate in which the carrier site is immersed) can explain a recently proposed uphill flow of water.	Water	319-324	LY6/PLAUR domain containing 4	Homo sapiens	113-116
10589502-3	1999	A 500 mL sample of tap water is preconcentrated by solid-phase extraction (SPE) with 300 mg combined polystyrene-divinylbenzene and methacrylate macroporous resins.	Water	23-28	nuclear RNA export factor 1	Homo sapiens	19-22
10556776-0	1999	Hypothalamic-pituitary-adrenal activity and pro-opiomelanocortin mRNA levels in the hypothalamus and pituitary of the rat are differentially modulated by acute intermittent morphine with or without water restriction stress.	Water	198-203	proopiomelanocortin	Rattus norvegicus	44-64
10556776-7	1999	(2) Morphine did not change pro-opiomelanocortin (POMC) mRNA levels in the anterior pituitary; whereas water restriction significantly increased the POMC mRNA levels.	Water	103-108	proopiomelanocortin	Rattus norvegicus	149-153
10556776-8	1999	The water restriction-induced increases of POMC mRNA in the anterior pituitary were absent in the rats which received morphine.	Water	4-9	proopiomelanocortin	Rattus norvegicus	43-47
10556776-10	1999	The morphine-induced increases in POMC mRNA in the hypothalamus were absent in the rat under the water restriction condition.	Water	97-102	proopiomelanocortin	Rattus norvegicus	34-38
28308316-9	1999	Xylem water deltaD was also strongly dependent on tree size (diameter at breast height), with smaller trees appearing to preferentially tap deeper sources of soil water than larger trees.	Water	6-11	nuclear RNA export factor 1	Homo sapiens	136-139
10574209-6	1999	The optimized procedure was applied to the analysis of HAAs in tap water and the results obtained by standard addition agreed with those of EPA method 552.2, whereas discrepancies due to matrix interferences were observed using external calibration.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
10527911-1	1999	We have recently cloned a gene, Cap43, that was significantly induced by exposure to nontoxic levels of both water-soluble and -insoluble Ni(2+) compounds.	Water	109-114	N-myc downstream regulated 1	Homo sapiens	32-37
10502060-4	1999	In vivo, IRBP-immunized mice were treated with a high dose of the antibody, and the EAU induction was examined both clinically and pathologically.	Water	84-87	retinol binding protein 3, interstitial	Mus musculus	9-13
10502060-7	1999	In vivo treatment with anti-CD4 monoclonal antibody inhibited development of EAU in a dose-dependent manner, while in vivo treatment with other monoclonal antibodies did not cause significant suppression of EAU.	Water	77-80	CD4 antigen	Mus musculus	28-31
10502060-9	1999	However, in in vivo treatment with monoclonal antibodies to these molecules, only anti-CD4 monoclonal antibody had a strong inhibitory effect on the development of EAU.	Water	164-167	CD4 antigen	Mus musculus	87-90
10582332-5	1999	The three-dimensional structure for Bacillus subtilis ferrochelatase, the only known "water-soluble" ferrochelatase, revealed that the protein contains two similar domains, each of which has a four-stranded beta-sheet flanked by alpha-helices; the active site was modeled to be in a cleft defined by the two domains.	Water	86-91	ferrochelatase	Homo sapiens	54-68
10582332-5	1999	The three-dimensional structure for Bacillus subtilis ferrochelatase, the only known "water-soluble" ferrochelatase, revealed that the protein contains two similar domains, each of which has a four-stranded beta-sheet flanked by alpha-helices; the active site was modeled to be in a cleft defined by the two domains.	Water	86-91	ferrochelatase	Homo sapiens	101-115
11534529-1	1999	Treatment of potable water samples with ascorbic acid has been investigated as a means for reducing residual halogen-based oxidants (disinfectants), i.e. HOCl, Cl2, Br2 and BrCl, prior to determination of EPA Method 551.1A and 551.1B analytes.	Water	21-26	endogenous retrovirus group W member 5	Homo sapiens	160-163
10504734-6	1999	Instead, structures of two states relevant to catalysis indicate that water, substrate and active site residues may provide an electron transfer pathway that exists only during the PHM catalytic cycle.	Water	70-75	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	181-184
10499997-1	1999	Trace metal pollutants in the surface water of the Houston Ship Channel were determined using inductively coupled plasma/mass spectrometry (ICP/MS).	Water	38-43	inositol polyphosphate-5-phosphatase D	Homo sapiens	59-63
10519171-2	1999	The aim of this study was to assess the relationships between daily tap-water consumption, As quantities thus ingested and biological arsenical impregnation.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
10497939-5	1999	The method was applied to the trace determination of several sulphonates present in tap water, seawater and water from the Ebro river.	Water	88-93	nuclear RNA export factor 1	Homo sapiens	84-87
10482794-0	1999	Transient MRI-detected water apparent diffusion coefficient reduction correlates with c-fos mRNA but not hsp70 mRNA induction during focal cerebral ischemia in rats.	Water	23-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-91
10482794-6	1999	The most significant finding of this work was that for both durations of ischemia, c-fos induction was observed in cortical and sub-cortical regions exhibiting a transient reduction in the apparent diffusion coefficient of water (ADC).	Water	223-228	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-88
10500466-1	1999	A case of thermal injury following the introduction of excessively hot tap water into the colon during irrigation of a sigmoid colostomy is described.	Water	75-80	nuclear RNA export factor 1	Homo sapiens	71-74
10433210-6	1999	Lower weight loss in CRH KO mice was associated with lower fractional loss of body water and protein.	Water	83-88	corticotropin releasing hormone	Mus musculus	21-24
10487329-13	1999	This implies that the mechanism of water-sodium excretion induced by NEP inhibitor is mediated by renal NO.	Water	35-40	membrane metallo-endopeptidase	Rattus norvegicus	69-72
10738183-12	1999	These results confirm that magnesium fortification of drinking water is capable of inhibiting atherogenesis in male LDL-receptor-deficient mice.	Water	63-68	low density lipoprotein receptor	Mus musculus	116-128
10376582-0	1999	JAMA Patient Page: water safety.	Water	19-24	F11 receptor	Homo sapiens	0-4
10362741-6	1999	Subcutaneous injections of equimolar doses of ANG I and ANG II (200 microliters; 2 x 10(-4) M) in water-sated rats similarly increased water intake by 2.4 +/- 0.5 (n = 16) and 2.	Water	135-140	angiogenin	Rattus norvegicus	46-49
10362741-6	1999	Subcutaneous injections of equimolar doses of ANG I and ANG II (200 microliters; 2 x 10(-4) M) in water-sated rats similarly increased water intake by 2.4 +/- 0.5 (n = 16) and 2.	Water	135-140	angiogenin	Rattus norvegicus	56-59
10362741-9	1999	Pretreatment with a low dose of captopril (2.3 x 10(-3) M) 10 min before the injection of ANG I caused a water intake of 2.8 +/- 0.5 ml (n = 10), whereas a high dose of captopril (4.6 x 10(-1) M) suppressed the dipsogenic response of ANG I entirely (n = 11).	Water	105-110	angiogenin	Rattus norvegicus	90-93
10417707-6	1999	Functional expression in Xenopus oocytes revealed that NtAQP1 can mediate glycerol transport in addition to water flow.	Water	108-113	probable aquaporin TIP1-1	Nicotiana tabacum	55-61
10379544-8	1999	Further, a system for 3D SAR distribution measurements in water phantom is explained.	Water	58-63	sarcosine dehydrogenase	Homo sapiens	25-28
10337604-3	1999	Thus we examined the relationship between first morning tap-water lead levels measured in homes in the 1970s and levels of lead in bone measured in the 1990s among middle-aged to elderly men who lived in those homes.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
10337604-9	1999	We conclude that ingestion of lead-contaminated tap water is an important predictor of elevated bone lead levels later in life.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
10780194-5	1999	RESULTS: The gastric emptying of this mineral water was significantly faster than that of tap water, both in dyspeptic patients and in normals.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
10225142-2	1999	The purpose of the present study was to test the effects of synthetic atrial natriuretic peptide (ANP) on renal haemodynamics and excretory capacities of salt and water in the rat during an "acute volumic stress", which was induced by brisk disturbances of the circulatory volume.	Water	163-168	natriuretic peptide A	Rattus norvegicus	70-96
10333180-6	1999	The introduction of halogen atoms increases the relative content of anti-syn and syn-anti conformations of DNPs as compared to the parent ones due to the formation of an energetically more favorable water structure around these conformations.	Water	199-204	synemin	Homo sapiens	73-76
10333180-6	1999	The introduction of halogen atoms increases the relative content of anti-syn and syn-anti conformations of DNPs as compared to the parent ones due to the formation of an energetically more favorable water structure around these conformations.	Water	199-204	synemin	Homo sapiens	81-84
10527454-11	1999	Fresh-water-soluble A beta 25-35 activated PI-PLC in SPM markedly by two- to threefold, but this effect was absent in the presence of 2 mM CaCl2.	Water	6-11	amyloid beta precursor protein	Rattus norvegicus	20-26
10022971-1	1999	Aquaporin-5 (AQP5) is a water channel protein and is considered to play an important role in water movement across the plasma membrane.	Water	24-29	aquaporin 5	Rattus norvegicus	0-11
10022971-1	1999	Aquaporin-5 (AQP5) is a water channel protein and is considered to play an important role in water movement across the plasma membrane.	Water	24-29	aquaporin 5	Rattus norvegicus	13-17
10022971-1	1999	Aquaporin-5 (AQP5) is a water channel protein and is considered to play an important role in water movement across the plasma membrane.	Water	93-98	aquaporin 5	Rattus norvegicus	0-11
10022971-1	1999	Aquaporin-5 (AQP5) is a water channel protein and is considered to play an important role in water movement across the plasma membrane.	Water	93-98	aquaporin 5	Rattus norvegicus	13-17
10022971-6	1999	These results suggest that AQP5 is one of the candidate molecules responsible for the water movement in the salivary glands.	Water	86-91	aquaporin 5	Rattus norvegicus	27-31
10067727-7	1999	These values are for milk reconstituted with aluminum-free water under laboratory conditions; formulas prepared with tap water in the University Hospital"s infant-feeding unit had even higher aluminum content.	Water	121-126	nuclear RNA export factor 1	Homo sapiens	117-120
10214678-5	1999	They were most often caused by tap water contamination associated with parasites and viruses, despite good compliance of the water treatment procedures.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
10218833-2	1999	N-(Furan-2-yl)carbonyl-Leu-L-Trp(P)-(OH)2 showed a 75-fold increase of the inhibiting activity against adamalysin II, a snake venom metalloproteinase structurally related to MMPs and TACE.	Water	37-41	ADAM metallopeptidase domain 17	Homo sapiens	183-187
9931374-0	1999	Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis.	Water	38-43	aquaporin 7	Rattus norvegicus	53-64
9931374-0	1999	Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis.	Water	38-43	aquaporin 7	Rattus norvegicus	66-70
9931374-2	1999	A strong candidate for a water efflux route, aquaporin 7 (AQP7), which is a water channel, was studied immunohistochemically in the rat testis.	Water	25-30	aquaporin 7	Rattus norvegicus	45-56
9931374-2	1999	A strong candidate for a water efflux route, aquaporin 7 (AQP7), which is a water channel, was studied immunohistochemically in the rat testis.	Water	25-30	aquaporin 7	Rattus norvegicus	58-62
9931374-2	1999	A strong candidate for a water efflux route, aquaporin 7 (AQP7), which is a water channel, was studied immunohistochemically in the rat testis.	Water	76-81	aquaporin 7	Rattus norvegicus	45-56
9931374-2	1999	A strong candidate for a water efflux route, aquaporin 7 (AQP7), which is a water channel, was studied immunohistochemically in the rat testis.	Water	76-81	aquaporin 7	Rattus norvegicus	58-62
9931374-10	1999	The present observations suggest that AQP7 contributes to the volume reduction of spermatids, since this water channel protein is localized on the plasma membrane covering the condensing cytoplasmic mass of the elongated spermatid, and since the seminiferous tubule fluid is hypertonic.	Water	105-110	aquaporin 7	Rattus norvegicus	38-42
9933751-2	1999	No information, however, is available on the plasma and urine levels of uroguanylin in nephrotic syndrome (NS), the state associated with sodium and water retention.	Water	149-154	guanylate cyclase activator 2B	Homo sapiens	72-83
10028067-0	1999	Legionnaires" disease on a cruise ship linked to the water supply system: clinical and public health implications.	Water	53-58	inositol polyphosphate-5-phosphatase D	Homo sapiens	34-38
10028067-3	1999	Legionella pneumophila serogroup 1 was isolated from the patient"s sputum and the ship"s water supply.	Water	89-94	inositol polyphosphate-5-phosphatase D	Homo sapiens	82-86
9987013-4	1999	In the A beta-(1-42)-infused rats, spontaneous alternation behaviour in a Y-maze and spatial memory in a water maze task were significantly impaired, as compared with A beta-(40-1)-infused control rats.	Water	105-110	amyloid beta precursor protein	Rattus norvegicus	7-13
11396041-6	1999	RESULTS: Increased consumption of infant formulas and decreased consumption of tap water and cow"s milk were seen in the CSFII for infants compared to the NFCS.	Water	83-88	nuclear RNA export factor 1	Homo sapiens	79-82
10465431-4	1999	The results indicate that brain slices have at least two distinct diffusing water compartments with apparent diffusion coefficients of 0.96+/-0.10x10(-3) mm2/s and 0.06+/-0.01x10(-3) mm2/s.	Water	76-81	PNMA family member 2	Homo sapiens	154-157
10022322-3	1998	Two recent examples (an EPA testing prioritization exercise for water disinfection byproducts and a regulatory action on 2,4,6-tribromophenol) illustrate issues involved in regulatory applications of SAR and commercial prediction systems.	Water	64-69	sarcosine dehydrogenase	Homo sapiens	200-203
21644686-4	1998	The analytical figures of merit are demonstrated by measurements of very low concentrations of Cr(VI) in tap water.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	105-108
9874038-0	1998	Nickel in tap water in Warsaw.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
9875338-0	1998	Select types of supporting cell in the inner ear express aquaporin-4 water channel protein.	Water	69-74	aquaporin 4	Homo sapiens	57-68
9875338-10	1998	Our findings indicate that AQP4 may facilitate osmotically driven water fluxes in the sensory epithelia of the inner ear and thus contribute to the volume and ion homeostasis at these sites.	Water	66-71	aquaporin 4	Homo sapiens	27-31
10453121-6	1998	Sixty (23%) women of the Bodija market mentioned that tap water was the source of drinking water for their children, while 91 (34%) brought water from their homes, and 45 (17%) bought it from vendors in the market.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
9871348-3	1998	Following a simple potassium citrate flotation concentrate clean-up procedure, mean recoveries were 56.7% for the tap water samples and 60.9% for river water samples.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
9799693-8	1998	The experiments are demonstrated on a 13C-labeled sample of the second PDZ domain from human phosphatase PTP1E in H2O solution.	Water	114-117	protein tyrosine phosphatase non-receptor type 13	Homo sapiens	105-110
9844138-10	1998	CONCLUSIONS: Our results demonstrate that water deprivation and salt restriction markedly enhance renal ANP mRNA, whereas water deprivation suppresses cardiac atrial ANP mRNA and plasma ANP concentrations.	Water	42-47	natriuretic peptide A	Rattus norvegicus	104-107
9844138-10	1998	CONCLUSIONS: Our results demonstrate that water deprivation and salt restriction markedly enhance renal ANP mRNA, whereas water deprivation suppresses cardiac atrial ANP mRNA and plasma ANP concentrations.	Water	122-127	natriuretic peptide A	Rattus norvegicus	166-169
9844138-10	1998	CONCLUSIONS: Our results demonstrate that water deprivation and salt restriction markedly enhance renal ANP mRNA, whereas water deprivation suppresses cardiac atrial ANP mRNA and plasma ANP concentrations.	Water	122-127	natriuretic peptide A	Rattus norvegicus	166-169
9755069-10	1998	These findings suggest a role of AQP5 in water transport to prevent dehydration or to secrete watery products in these tissues.	Water	41-46	aquaporin 5	Rattus norvegicus	33-37
9924276-5	1998	NSP-isolate ingestion induced significant increases in the number of defecations and stool weight resulting from increases in water, DM and microbial mass excretion.	Water	126-131	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	0-3
9917006-2	1998	WAP-8294A, produced by Lysobacter sp., is a complex consisting of water soluble depsipeptide antibiotics.	Water	66-71	whey acidic protein	Mus musculus	0-3
9845004-5	1998	In healthy women (21-39 y, n=6), an oral water load (OWL, 20 ml/bw) significantly suppressed the plasma levels of AVP, OXT and cortisol, and the PRL level too tended to decrease.	Water	41-46	oxytocin/neurophysin I prepropeptide	Homo sapiens	119-122
9845004-8	1998	These data suggest that alterations in AVP and OXT hypersecretion may contribute to the water retention in hyperprolactinaemia.	Water	88-93	oxytocin/neurophysin I prepropeptide	Homo sapiens	47-50
9741850-7	1998	Mutations of various residues around the active site provide further insight into the corresponding experimental results and, in fact, suggest an important role for the solvent water molecules in the CA II catalytic mechanism.	Water	177-182	carbonic anhydrase 2	Homo sapiens	200-205
9751227-0	1998	Glucagon-like peptide-1 (7-36) amide administered into the third cerebroventricle inhibits water intake in rats.	Water	91-96	glucagon	Rattus norvegicus	0-23
9751227-4	1998	We further examined whether GLP-1 injected icv in rats has a specific inhibitory effect on water intake.	Water	91-96	glucagon	Rattus norvegicus	28-33
9751227-5	1998	It was found that GLP-1 reduced water deprivation-induced drinking.	Water	32-37	glucagon	Rattus norvegicus	18-23
9751227-7	1998	Finally, when 2 microg of GLP-1 were injected into the third ventricle, it only suppressed water deprivation-induced water intake and failed to influence spontaneous food and water intakes or induce conditioned taste aversion.	Water	91-96	glucagon	Rattus norvegicus	26-31
9751227-7	1998	Finally, when 2 microg of GLP-1 were injected into the third ventricle, it only suppressed water deprivation-induced water intake and failed to influence spontaneous food and water intakes or induce conditioned taste aversion.	Water	117-122	glucagon	Rattus norvegicus	26-31
9819657-1	1998	PURPOSE: To identify the sources for the exceeding of the upper limit of the AOX (adsorbable organic halogen, X = Cl, Br, I) in hospital waste-water and to estimate the contribution of hospital waste-water to the AOX of municipal waste-water.	Water	143-148	acyl-CoA oxidase 1	Homo sapiens	77-80
9819657-2	1998	METHODS: For several hospitals with different medical directions, the expected AOX-concentration, as far as it is caused by iodine contrast media, was ascertained by the contrast media consumption and the water consumption.	Water	205-210	acyl-CoA oxidase 1	Homo sapiens	79-82
9819657-4	1998	RESULTS: The AOX-concentration of hospital waste-water varies between 0.41 mg/l and 0.94 mg/l.	Water	49-54	acyl-CoA oxidase 1	Homo sapiens	13-16
9819657-6	1998	Hospitals with a radiological department may exceed the upper limit of the AOX which has to be observed in German municipal waste-water.	Water	130-135	acyl-CoA oxidase 1	Homo sapiens	75-78
9867427-0	1998	Tap water scald burns in children.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
9785606-3	1998	Development of EAU induced by the interphotoreceptor retinoid binding protein (IRBP) was abolished almost completely by either TBI or Cy treatment, followed by SBMT, instituted one week after priming.	Water	15-18	retinol binding protein 3, interstitial	Mus musculus	34-77
9785606-3	1998	Development of EAU induced by the interphotoreceptor retinoid binding protein (IRBP) was abolished almost completely by either TBI or Cy treatment, followed by SBMT, instituted one week after priming.	Water	15-18	retinol binding protein 3, interstitial	Mus musculus	79-83
9749401-0	1998	Outbreak of nosocomial urinary tract infections due to Pseudomonas aeruginosa in a paediatric surgical unit associated with tap-water contamination.	Water	128-133	nuclear RNA export factor 1	Homo sapiens	124-127
9749401-5	1998	Multiple P. aeruginosa isolates were also found in the tap water, as the only putative source of contamination.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
9749401-9	1998	These results illustrate an unexpected risk of nosocomial infection and emphasizes the importance of checking tap water to prevent bacterial contamination through handwashing in contaminated water.	Water	114-119	nuclear RNA export factor 1	Homo sapiens	110-113
9751446-3	1998	Conformers generated from the D2O-H2O data superposed on the corresponding main-chain atoms in the crystal structure of endothelin 1 and the solution structure of BQ-123 with root mean square co-ordinate differences of 0.9A and 0.77A, respectively.	Water	34-37	endothelin-1	Oryctolagus cuniculus	120-132
9692974-5	1998	Unlike the other isozymes of this class of CA, for which Kcat/K(m) is described by the single ionization of zinc-bound water, CA VII exhibits a pH profile for Kcat/K(m) for CO2 hydration described by two ionizations at pKa 6.2 and 7.5, with a maximum approaching 8 x 10(7) M-1 s-1.	Water	119-124	carbonic anhydrase 7	Mus musculus	126-132
9682912-5	1998	Two additional OLFs with Mr around 400 eluted in a late subfraction FIV/8 which resolved after reverse-phase HPLC into a more polar OLF- (water phase) and a more apolar OLF-2 (20% acetonitrile).	Water	138-143	transmembrane O-mannosyltransferase targeting cadherins 1	Homo sapiens	15-18
9647215-4	1998	IL-12 p40-deficient mice (12KO) were resistant to EAU induced with the uveitogenic retinal Ag interphotoreceptor retinoid binding protein (IRBP).	Water	50-53	interleukin 12b	Mus musculus	0-9
9647215-4	1998	IL-12 p40-deficient mice (12KO) were resistant to EAU induced with the uveitogenic retinal Ag interphotoreceptor retinoid binding protein (IRBP).	Water	50-53	retinol binding protein 3, interstitial	Mus musculus	94-137
9647215-4	1998	IL-12 p40-deficient mice (12KO) were resistant to EAU induced with the uveitogenic retinal Ag interphotoreceptor retinoid binding protein (IRBP).	Water	50-53	retinol binding protein 3, interstitial	Mus musculus	139-143
9639628-4	1998	The source of infection was identified as contaminated tap water.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
9651449-0	1998	Tap water scald burns in children, by K. W. Feldman, R. T. Schaller, J.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
9697363-0	1998	[Late manifestation of a form of Indian childhood cirrhosis based on chronic copper poisoning caused by sour tap water].	Water	113-118	nuclear RNA export factor 1	Homo sapiens	109-112
10684014-2	1998	The results showed that the morphology of RBC elapsed 6 days in water and air seemed to retain their integrity.	Water	64-69	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	42-45
9648185-2	1998	Humidity in the form of molecular water vapor is an essential requirement for intubated patients, and can be beneficial to nonintubated patients receiving CPAP or oxygen therapy.	Water	34-39	centromere protein J	Homo sapiens	155-159
9612421-2	1998	One of those peptides, adrenomedullin (AM) also has been demonstrated to act centrally in conscious rats to inhibit water drinking and salt appetite and, in anesthetized rats, surprisingly to increase blood pressure.	Water	116-121	adrenomedullin	Rattus norvegicus	23-37
21651287-6	1998	The procedure has been applied to tap water samples (spiked at 0.10 and 0.20 mug L(-)(1) levels) with good results, similar to those obtained with a HPLC system with a conventional fluorescence detector.	Water	38-43	nuclear RNA export factor 1	Homo sapiens	34-37
9570105-0	1998	AOX-emissions from hospitals into municipal waste water.	Water	50-55	acyl-CoA oxidase 1	Homo sapiens	0-3
9679709-8	1998	When water was used as intermedium between LCAs and phantom, a maximum SAR difference of 27% was calculated.	Water	5-10	sarcosine dehydrogenase	Homo sapiens	71-74
9679709-11	1998	The average SAR differences with and without water as intermedium were 7% respectively 11%, indicating that the GBM can provide good qualitative information about the SAR distribution of dual LCA-arrays.	Water	45-50	sarcosine dehydrogenase	Homo sapiens	167-170
9588201-0	1998	Acetylcholine acts on M3 muscarinic receptors and induces the translocation of aquaporin5 water channel via cytosolic Ca2+ elevation in rat parotid glands.	Water	90-95	aquaporin 5	Rattus norvegicus	79-89
9599288-6	1998	Aldehyde dehydrogenase class 3 and transketolase are metabolic enzymes comprising extremely high proportions of the water-soluble proteins of the cornea and may have structural as well as enzymatic roles, reminiscent of lens enzyme-crystallins.	Water	116-121	transketolase	Mus musculus	35-48
9535834-7	1998	These new findings lead us to conclude that the formation of the alpha1beta1 contact produces in the beta chain a conformational constraint whereby the distal histidine at position 63 is tilted away slightly from the bound dioxygen, preventing the proton-catalyzed displacement of O-2 by a solvent water molecule.	Water	298-303	immunoglobulin kappa variable 1D-39	Homo sapiens	281-284
9637077-0	1998	Lognormal distributions for total water intake and tap water intake by pregnant and lactating women in the United States.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
9545022-1	1998	Glucagon-like peptide (7-36) amide (GLP-1) acutely inhibits food and water consumption in rats after intracerebroventricular (icv) administration.	Water	69-74	glucagon	Rattus norvegicus	36-41
9507149-7	1998	Surprisingly, in the water-finding test, the nociceptin receptor-knockout mice showed an enhanced retention of spatial attention (latent learning) compared to wild-type mice.	Water	21-26	opioid receptor-like 1	Mus musculus	45-64
9486141-8	1998	Maximum inward current was largest in ClC-2 delta NT-injected oocytes (-5.9 +/- 0.4 microA), followed by ClC-2-injected oocytes (-4.3 +/- 0.6 microA), and smallest in water-injected oocytes (-0.2 +/- 0.2 microA), whereas the order of increase in oocyte diameter was as follows: water-injected oocytes (9.0 +/- 0.2%) &gt; ClC-2-injected oocytes (5.3 +/- 0.5%) &gt; ClC-2 delta NT-injected oocytes (1.1 +/- 0.2%).	Water	167-172	chloride channel protein 2	Oryctolagus cuniculus	38-43
9486417-6	1998	We report here that all the peptides are immunogenic but only one peptide, K2, which consisted of IRBP201-216 residues, induces EAU in various mice carrying H-2Ak.	Water	128-131	retinol binding protein 3, interstitial	Mus musculus	98-102
9551332-0	1998	[Therapy of hyperhidrosis with tap water iontophoresis.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
9512087-1	1998	It has recently been reported that kappa-opioid receptor agonists inhibit antidiuretic hormone secretion and promote water excretion in humans and animals.	Water	117-122	opioid receptor kappa 1	Homo sapiens	35-56
9426298-5	1998	Accumulation of organic osmolytes and synthesis of HSP27 and HSP72 was initiated by hypertonic stress (increasing the osmolality of the medium from 290 to 600 mosmol/kg H2O by NaCl addition).	Water	169-172	heat shock protein family B (small) member 1	Canis lupus familiaris	51-56
9517519-6	1998	The fraction time esophageal pH &lt;4 was increased after both alcoholic beverages compared with tap water (0.9%; 0.2-5.8%; P &lt; 0.01 versus white wine, P &lt; 0.05 versus red wine) with a greater fraction time after white wine (13.2; 0.3-58.1 ) than after red wine (2.3; 0.7-24.4; P &lt; 0.05).	Water	101-106	nuclear RNA export factor 1	Homo sapiens	97-100
9458894-5	1998	The present study suggests that GLP-1 infusions into the PVN reduce food and water intake without producing illness or disrupting locomotor behavior.	Water	77-82	glucagon	Rattus norvegicus	32-37
9458896-2	1998	Intracerebroventricular injection of neurotensin protects rats from gastric mucosal injury caused by cold water restraint (CWR).	Water	106-111	neurotensin	Rattus norvegicus	37-48
9449102-1	1998	Water tubing (the pulling of an inner tube behind a power boat) is growing in popularity and unfortunately is becoming an increasing source of pediatric trauma.	Water	0-5	ataxin 1 like	Homo sapiens	58-62
9398305-1	1997	Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site.	Water	211-216	carbonic anhydrase 5A	Homo sapiens	131-151
9398305-1	1997	Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site.	Water	211-216	carbonic anhydrase 5A	Homo sapiens	153-157
9398308-6	1997	Metal geometry changes to trigonal bipyramidal in H119N CAII due to the addition of a second water molecule to the zinc coordination polyhedron and also in H94N CAII due to the displacement of zinc-bound hydroxide by the bidentate coordination of a Tris molecule.	Water	93-98	carbonic anhydrase 2	Homo sapiens	56-60
9476455-9	1997	In addition, certain groups of children were much likely to develop protozoal infections including children whose families lacked tap water inside dwelling (OR = 1.85, 95 per cent CI = 1.26-2.77) and disposed human excreta in septic tank very close to the dwelling (OR = 2.17, 95 per cent CI = 1.43-3.75).	Water	134-139	nuclear RNA export factor 1	Homo sapiens	130-133
9374582-4	1997	Most often tap water, either in the form of supplemental feedings or overly dilute formula, has been given in excessive amounts over relatively short periods of time.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
9463929-0	1997	Risk characterization of methyl tertiary butyl ether (MTBE) in tap water.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
9463929-10	1997	Although some individuals may be exposed to very high concentrations of MTBE in tap water immediately following a localized spill, these exposures are likely to be brief in duration due to large-scale dilution and rapid volatilization of MTBE, the institution of emergency response and remediation measures to minimize human exposures, and the low taste and odor thresholds of MTBE which ensure that its presence in tap water is readily detected at concentrations well below the threshold for human injury.	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
9374812-9	1997	These data suggest that AP-mediated long-term action of AVP augments water retention and sustains bradycardia.	Water	69-74	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	56-59
9427073-10	1997	A significantly greater rate of clinical remission was observed in subjects enjoying home tap water supplies (p &lt; 0.01).	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
9372633-1	1997	The variation in lead concentration was measured by thermal ionisation mass spectrometry isotope dilution in household tap water throughout the day when the plumbing system was not fully flushed.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
9372633-3	1997	High precision lead isotopic measurements showed that approximately 50% of the lead in these water samples derives from the tap "housing" compared with the overall household system.	Water	93-98	nuclear RNA export factor 1	Homo sapiens	124-127
9463965-4	1997	The proposed method was validated by analysing freeze-dried tap water samples with a high content in pesticides of different chemical functionalities.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
9363996-5	1997	Exposure of buccal cell cultures to various organic or water-based extracts of products related to the use of tobacco and betel quid, decreased both cell survival (measured by reduction of tetrazolium dye) and MGMT activity (measured subsequently to the exposures in cellular extracts).	Water	55-60	O-6-methylguanine-DNA methyltransferase	Homo sapiens	210-214
9386008-0	1997	Fos expression in the rat parabrachial and Kolliker-Fuse nuclei after electrical stimulation of the trigeminal ethmoidal nerve and water stimulation of the nasal mucosa.	Water	131-136	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
9299765-3	1997	Drinking water samples were taken from the first tap after the water was led into the building.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	49-52
9307034-10	1997	Because perlecan is released from transthyretin in water, the binding might be due to hydrophobic interactions.	Water	51-56	transthyretin	Homo sapiens	34-47
9370334-2	1997	Cardiolipin synthase is a unique membrane-bound enzyme in that it utilizes two phospholipids, both insoluble in water, as substrates.	Water	112-117	cardiolipin synthase	Saccharomyces cerevisiae S288C	0-20
9324135-3	1997	Under conditions of cold water restraint, pretreatment with central neurotensin is associated with maintenance of gastric mucosal blood flow and an increase in endogenous gastric mucosal PGE2 activity.	Water	25-30	neurotensin	Rattus norvegicus	68-79
9324135-4	1997	In addition, pretreatment with 6-hydroxy dopamine into the mesolimbic nuclei, which depletes them of endogenous dopamine, prior to exposure to cold water restraint, ameliorates the protective effect of central neurotensin.	Water	148-153	neurotensin	Rattus norvegicus	210-221
9324135-7	1997	Taken together, these observations support the hypothesis that centrally administered neurotensin, particularly into the nuclei of the mesolimbic dopamine system, confers protection against gastric mucosal injury produced by 2 hours of cold water restraint.	Water	241-246	neurotensin	Rattus norvegicus	86-97
9642333-3	1997	POR, POV and vanadate were administrated in drink water.	Water	50-55	cytochrome p450 oxidoreductase	Rattus norvegicus	0-3
9310837-2	1997	In these simulations, a loosely structured network of water molecules is present in the binding groove between the peptide and the MHC molecule, and may be important in completing the peptide-MHC interface.	Water	54-59	major histocompatibility complex, class I, C	Homo sapiens	131-134
9310837-2	1997	In these simulations, a loosely structured network of water molecules is present in the binding groove between the peptide and the MHC molecule, and may be important in completing the peptide-MHC interface.	Water	54-59	major histocompatibility complex, class I, C	Homo sapiens	192-195
9276712-1	1997	Aquaporin-4 (AQP4) is a mercurial-insensitive, water-selective channel that is expressed in astroglia and basolateral plasma membranes of epithelia in the kidney collecting duct, airways, stomach, and colon.	Water	47-52	aquaporin 4	Mus musculus	0-11
9276712-1	1997	Aquaporin-4 (AQP4) is a mercurial-insensitive, water-selective channel that is expressed in astroglia and basolateral plasma membranes of epithelia in the kidney collecting duct, airways, stomach, and colon.	Water	47-52	aquaporin 4	Mus musculus	13-17
9276712-5	1997	Water permeability in an AQP4-enriched brain vesicle fraction in [+/+] mice was high and mercurial insensitive, and was decreased by 14-fold in [-/-] mice.	Water	0-5	aquaporin 4	Mus musculus	25-29
9351242-2	1997	Proline accumulation in response to water stress and salinity is preceded by a rapid increase of the mRNA level of delta 1-pyrroline-5-carboxylate synthase (P5CS) controlling the rate-limiting step of glutamate-derived proline biosynthesis.	Water	36-41	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	157-161
9323392-8	1997	Restaurant water and ice samples contained more than 40 milligrams of fluoride per liter (mg/L), more than 20 times the recommended limit, and a tap water sample from a house located near the main treatment plant contained 200 mg/l of fluoride.	Water	149-154	nuclear RNA export factor 1	Homo sapiens	145-148
9446306-1	1997	Efficacy of spa treatment with moderately mineralized mineral water from the spring utilized by balneological sanatorium Uva in the Republic of Udmurtia was studied in 524 patients with chronic atrophic gastritis concomitant with chronic cholecystitis and hypokinesia of the biliary ducts.	Water	62-67	surfactant protein A2	Homo sapiens	12-15
9311665-3	1997	The aim of the present study was to investigate the mechanisms of the peptide YY effect on vasoactive intestinal peptide (VIP)-stimulated jejunal net water flux in the rat.	Water	150-155	peptide YY	Rattus norvegicus	70-80
9311665-5	1997	A small peptide YY dose (10 pmol/kg) inhibited significantly (P &lt; 0.005) the jejunal net water flux produced by 30 microg/kg per h of VIP.	Water	92-97	peptide YY	Rattus norvegicus	8-18
9311665-7	1997	These results suggest that peptide YY inhibits VIP-stimulated jejunal net water flux in vivo through a neural mechanism implicating the participation of nicotinic synapses, alpha2-adrenoceptors and sigma receptors.	Water	74-79	peptide YY	Rattus norvegicus	27-37
9252401-5	1997	The expression of AQP7 in oocytes stimulated the osmotic water permeability by 10-fold which was not inhibited by 0.3 mM mercury chloride.	Water	57-62	aquaporin 7	Rattus norvegicus	18-22
9288684-16	1997	Distension of the stomach with peptone via a barostat attached to the gastric cannula (5 cm H2O, 30 min), produced 3-fold increases in plasma gastrin in both control and denervated rats.	Water	92-95	gastrin	Rattus norvegicus	142-149
19679908-7	1997	Tap-water burns are considerable more common in Iceland compared to other countries.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
9272766-3	1997	In contrast, blockade of CB1 receptors only marginally affects regular chow intake or water drinking.	Water	86-91	cannabinoid receptor 1	Rattus norvegicus	25-28
9228799-3	1997	The lowest detectable concentrations of the pesticides are between 1-5 ng l(-1), relative recoveries range from 92-105% in tap water spiked at 100 ng l(-1) and the relative standard deviations are in the range 5-12%.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
9227628-5	1997	AM (10(-8) M) slightly increased osmotic water permeability by 24% in perfused terminal IMCD.	Water	41-46	adrenomedullin	Rattus norvegicus	0-2
9174082-1	1997	The relation between c-fos expression in the forebrain of Lister hooded rats and water and NaCl intakes was examined in response to systemic injection of angiotensin II, desoxycorticosterone, angiotensin II and desoxycorticosterone together, frusemide or low sodium diet, all treatments that induce a sodium appetite.	Water	81-86	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-26
9154891-10	1997	Extravascular lung water (measured with radiolabeled erythrocytes) was decreased in the KGF/ANTU group.	Water	19-24	fibroblast growth factor 7	Rattus norvegicus	88-91
9109536-9	1997	The addition of a water-soluble analogue of vitamin E (Trolox) inhibited effects of A beta on lipid peroxidation and fluidity in SPM.	Water	18-23	amyloid beta precursor protein	Rattus norvegicus	84-90
9170841-3	1997	The accumulation of 14C-cystine in water insoluble protein (WIP) of the lens was increased, especially in lens recognized cataract.	Water	35-40	WAS/WASL interacting protein family, member 1	Rattus norvegicus	60-63
9150766-1	1997	Chlorinated tap water often contains 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX), which is a potent directly acting bacterial mutagen.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
9100580-8	1997	In contrast, fasted subjects who received tap water did not respond to the Trier Social Stress Test with significant changes in cortisol levels (F = 6.27, P &lt; 0.001).	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
9134720-4	1997	HPC bacteria were isolated from bottled and tap water samples by enumerating them under physical and chemical conditions analogous to human physiology.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
9122260-9	1997	We conclude that guanylin and uroguanylin evolved distinctly different structures, which enables both peptides to regulate, in a pH-dependent fashion, the activity of receptors that control intestinal salt and water transport via cGMP.	Water	210-215	guanylate cyclase activator 2B	Homo sapiens	30-41
9164028-5	1997	The most likely source of infection in Sri Lanka is ingestion of the infected first intermediate host, Cyclops, in water.	Water	115-120	sorcin	Homo sapiens	39-42
9059515-9	1997	However, deletions of the proline-rich region, including the five amino acids nearest to the C-terminus, resulted in approximately an 8-fold increase in the specific activity of LCAT towards the water-soluble substrate, p-nitrophenylbutyrate.	Water	195-200	lecithin-cholesterol acyltransferase	Homo sapiens	178-182
9059515-10	1997	This suggests that the C-terminal proline-rich region may interfere with the access of this water-soluble substrate to the active site of LCAT, and may form part of a protective covering of the active site of LCAT while in solution.	Water	92-97	lecithin-cholesterol acyltransferase	Homo sapiens	138-142
9059515-10	1997	This suggests that the C-terminal proline-rich region may interfere with the access of this water-soluble substrate to the active site of LCAT, and may form part of a protective covering of the active site of LCAT while in solution.	Water	92-97	lecithin-cholesterol acyltransferase	Homo sapiens	209-213
9176054-9	1997	In the lens, the major water channel is AQP1 with detectable levels of AQP4 and AQP5 that are approximately 1000-fold lower than AQP1.	Water	23-28	aquaporin 5	Rattus norvegicus	80-84
9147958-6	1997	RESULTS: The development of EAU could be significantly prevented by adoptive transfer of CD4+ T cells, whereas CD8+ T cells could not suppress the onset.	Water	28-31	Cd4 molecule	Rattus norvegicus	89-92
9022041-6	1997	Induction of Ha-ras gene expression in mice was consistently observed after 48 hr of exposure to drinking water containing IPTG.	Water	106-111	Harvey rat sarcoma virus oncogene	Mus musculus	13-19
8978356-10	1997	CONCLUSIONS: NHE3 seems to be the Na+/H+ exchange isoform involved in the modulation of basal ileal water and sodium absorption.	Water	100-105	solute carrier family 9 member A3	Homo sapiens	13-17
8978356-11	1997	Both Na+/H+ exchange mediated through NHE3 and Na(+)-glucose cotransport contribute to basal ileal water and sodium absorption.	Water	99-104	solute carrier family 9 member A3	Homo sapiens	38-42
8989992-3	1997	Therefore, mammals have a liver enzyme bilirubin UDP-glucuronosyltransferase (B-UGT), which conjugates bilirubin with glucuronic acid, thereby making the molecule much more water soluble.	Water	173-178	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	49-76
9096270-7	1997	Each subject provided a 24-hour urine collection after ingestion of mineral water over a period of 3 days; after a suitable rest period the protocol was repeated using local tap water (Ca: 13 ppm, Mg: 1 ppm).	Water	178-183	nuclear RNA export factor 1	Homo sapiens	174-177
8987973-4	1996	Furthermore, an alternative proton transfer pathway, consisting of an active site solvent-mediated proton transfer from zinc-water to imidazole buffer, is inhibited in the A65F, A65L, and A65H CAII variants.	Water	125-130	carbonic anhydrase 2	Homo sapiens	193-197
8973206-1	1996	Aquaporin-1 (AQP1) is a member of a family of integral membrane proteins, the aquaporins, which function as molecular channels for the movement of water across the plasma membrane.	Water	147-152	aquaporin 1	Gallus gallus	13-17
19245448-1	1996	Synopsis Vichy spa water is essentially known for its therapeutic action on liver and bile duct functions.	Water	19-24	surfactant protein A2	Homo sapiens	15-18
19245448-6	1996	The results showed a statistically significant increase (p&lt;0.05) in the activity of the enzyme in the presence of Vichy spa water both in vitro and in vivo.	Water	127-132	surfactant protein A2	Homo sapiens	123-126
8994387-18	1996	Whether the release of PYY by luminal factors is coupled to water and electrolyte transfer via a local/paracrine pathway remains an open question which requires additional work with the isolated vascularly perfused colon preparation.	Water	60-65	peptide YY	Rattus norvegicus	23-26
8972606-7	1996	In FeSOD-overproducing plants under salt stress, the induction of cytosolic and chloroplastic Cu/ZnSOD was suppressed, whereas induction of a water-soluble chloroplastic ascorbate peroxidase isozyme was promoted.	Water	142-147	Fe superoxide dismutase	Arabidopsis thaliana	3-8
8944663-1	1996	Expression of Na(+)-glucose cotransporters of the SGLT-1 type by Xenopus laevis oocytes increased the osmotic water permeability (Pf) of oocytes by a factor of 1.9-2.8, in the presence and in the absence of 5 mM extracellular glucose.	Water	110-115	solute carrier family 5 (sodium/glucose cotransporter), member 1, gene 2 L homeolog	Xenopus laevis	50-56
8944663-6	1996	These findings suggest that SGLT-1 forms a pore that allows the transmembrane passage of water and that water and glucose traverse the protein through this pore.	Water	89-94	solute carrier family 5 (sodium/glucose cotransporter), member 1, gene 2 L homeolog	Xenopus laevis	28-34
8944663-7	1996	The finding that removal of extracellular Na+ abolishes the increase in Pf attributable to SGLT-1 suggests that extracellular Na+ is required to maintain patency of this transporter"s water-permeable transmembrane pore.	Water	184-189	solute carrier family 5 (sodium/glucose cotransporter), member 1, gene 2 L homeolog	Xenopus laevis	91-97
8875818-5	1996	In the LPM, the spaces between the elastin fibrils are filled with water, and in the VPM these spaces collapse when the water is removed.	Water	67-72	elastin	Homo sapiens	35-42
8892418-0	1996	Is lead in tap water still a public health problem?	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
8892418-7	1996	MAIN OUTCOME MEASURES: Mean geometric blood lead concentrations and the prevalence of raised tap water lead concentration.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
8892418-9	1996	Tap water lead remained the main correlate or raised maternal blood lead concentrations and accounted for 62% and 76% of cases of maternal blood lead concentrations above 5 and 10 micrograms/dl (0.24 and 0.48 mumol/l) respectively.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
8892418-10	1996	The geometric mean maternal blood lead concentration was 3.65 micrograms/dl (0.18 mumol/l) in a random sample of mothers and 3.16 micrograms/dl (0.15 mumol/l) in mothers whose tap water lead concentrations were consistently below 2 micrograms/l (9.7 nmol/l).	Water	180-185	nuclear RNA export factor 1	Homo sapiens	176-179
8892418-12	1996	An estimated 13% of infants were exposed via bottle feeds to tap water lead concentrations exceeding the World Health Organisation"s guideline of 10 micrograms/l (48.3 nmol/l).	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
8899886-5	1996	Water intake inhibits c-fos in the SON and PVN; whether this is a direct interaction between Ang-II and altered osmolality on magnocellular neurons or a secondary event of an action elsewhere (e.g., in the AV3V) remains uncertain.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	22-27
8905336-9	1996	These results suggest that some calmodulin antagonists and anesthetics in water-soluble bases might be a choice for the treatment of 2-chloroethylethyl sulfide-induced skin burns.	Water	74-79	calmodulin 2	Mus musculus	32-42
8798691-17	1996	The redistribution of AQP2 in CD8 cells was accompanied by an approximately 6-fold increase in osmotic water permeability coefficient (Pf), which was inhibited by 0.3 m HgCl2.	Water	103-108	CD8a molecule	Homo sapiens	30-33
8897973-6	1996	Intracerebroventricular GLP-1 profoundly inhibited angiotensin II-induced drinking behavior in rats, and water intake was suppressed by exogenous GLP-1 in rats habituated to a water restriction schedule.	Water	105-110	glucagon	Rattus norvegicus	146-151
8871546-1	1996	The so-called spine of hydration in the minor groove of AnTn tracts in DNA is thought to stabilise the structure, and kinetically bound water detected in the minor groove of such DNA species by NMR has been attributed to a narrow minor groove [Liepinsh, E., Leupin, W. and Otting, G. (1994) Nucleic Acids Res.	Water	136-141	serpin family B member 4	Homo sapiens	258-264
8823202-3	1996	It has been shown previously that the OSCP, b", d, and F6 proteins can be assembled in vitro into a water soluble complex named the "stalk".	Water	100-105	ATP synthase peripheral stalk subunit OSCP	Bos taurus	38-42
8908254-5	1996	At last follow-up examination, air conduction thresholds of patients drinking fluoridated tap water were found to be significantly better than those of patients drinking fluoride-poor water, likewise there were significant differences in bone conduction thresholds at 1, 2, and 4 kHz.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
8853437-11	1996	Furthermore, it is possible that some of the previously described changes in renal handling of divalent cations and water in the perinatal and immediate postnatal period are related, in part, to the increasing levels of expression of the CaR and resultant inhibitory effects on the actions of PTH and antidiuretic hormone on the developing nephron.	Water	116-121	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	238-241
8806217-1	1996	Contaminated tap water is one source of potentially hazardous air pollutants in residential indoor air.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
8897087-1	1996	A diastereomeric mixture of the tripeptide Boc-Ala-Ile-Aib-OMe crystallized in the space group P1 from CH3OH/H2O.	Water	109-112	ANIB1	Homo sapiens	55-58
8905967-6	1996	In experiment A), in the group given 50% calorie restricted food from 2 weeks before immunization, and in experiment B), in the group given 50% calorie restricted food from 4 weeks before immunization, the onset of EAU was significantly delayed, the clinical symptoms were lessened, and delayed hypersensitivity against IRBP was suppressed.	Water	215-218	retinol binding protein 3	Rattus norvegicus	320-324
8768930-0	1996	Salt and water homeostasis: uroguanylin is a circulating peptide hormone with natriuretic activity.	Water	9-14	guanylate cyclase activator 2B	Homo sapiens	28-39
8768930-14	1996	Moreover, uroguanylin and guanylin participate cooperatively in an intrinsic pathway for regulation of intestinal salt and water transport, thus providing another means of influencing salt and water homeostasis in addition to the renal actions of uroguanylin.	Water	123-128	guanylate cyclase activator 2B	Homo sapiens	10-21
8768930-14	1996	Moreover, uroguanylin and guanylin participate cooperatively in an intrinsic pathway for regulation of intestinal salt and water transport, thus providing another means of influencing salt and water homeostasis in addition to the renal actions of uroguanylin.	Water	193-198	guanylate cyclase activator 2B	Homo sapiens	10-21
9132576-1	1996	Health effects associated with ingestion of nitrate-contaminated water have included methemoglobinemia (i.e., blue baby syndrome) in infants and spontaneous abortions in laboratory animals and livestock; however, only one study in humans has reported an association between increased methemoglobin levels and spontaneous abortion.	Water	65-70	hemoglobin subunit gamma 2	Homo sapiens	85-98
8698224-0	1996	Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress.	Water	86-91	regenerating family member 1 alpha	Rattus norvegicus	0-3
8698224-8	1996	Levels of both Reg mRNA and its product were markedly increased in the water immersion-induced gastric lesions.	Water	71-76	regenerating family member 1 alpha	Rattus norvegicus	15-18
8698224-9	1996	CONCLUSIONS: Reg mRNA and its product are expressed in gastric enterochromaffin-like cells, and their levels are increased during the healing process of water immersion-induced gastric lesions.	Water	153-158	regenerating family member 1 alpha	Rattus norvegicus	13-16
8925642-5	1996	The results showed a significant colecystocinetic effect of the mineral water compared with tap water.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
8808762-1	1996	The effects of surfactant-associated protein A (SP-A) on lipid adsorption to the air-water interface and accumulation of dipalmitoylphosphatidylcholine (DPPC) in the surface region were investigated at 37 degrees C. Dispersions used were bovine pulmonary lipid extract surfactant with or without neutral lipid (NL).	Water	85-90	pulmonary surfactant-associated protein A	Bos taurus	48-52
8808762-11	1996	These results indicate that neutral lipid cooperates with surfactant-associated protein A to organize dipalmitoylphosphatidylcholine in the surface films and enhance formation of a DPPC-rich reservoir below the air-water interface.	Water	215-220	pulmonary surfactant-associated protein A	Bos taurus	58-89
8755678-8	1996	In contrast, drinking tap water decreased the risk.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
8928918-3	1996	The apical entries of Ca2+ and Zn2+, but not Na2+ and Cl-, were inhibited by addition of La to the water.	Water	99-104	carbonic anhydrase II	Oncorhynchus mykiss	22-25
8617373-2	1996	Water flow into the expanding vacuole is driven by ion accumulation, which in turn is energized by the vacuolar H+-ATPase (V-ATPase).	Water	0-5	V-type proton ATPase catalytic subunit A	Zea mays	103-121
8617373-2	1996	Water flow into the expanding vacuole is driven by ion accumulation, which in turn is energized by the vacuolar H+-ATPase (V-ATPase).	Water	0-5	V-type proton ATPase catalytic subunit A	Zea mays	123-131
8601457-4	1996	Expression of hAQP4 cRNA in Xenopus oocytes resulted in a significant increase in osmotic water permeability, indicating that this protein functions as a water channel.	Water	90-95	aquaporin 4	Homo sapiens	14-19
8601457-4	1996	Expression of hAQP4 cRNA in Xenopus oocytes resulted in a significant increase in osmotic water permeability, indicating that this protein functions as a water channel.	Water	154-159	aquaporin 4	Homo sapiens	14-19
8740859-4	1996	In some cases colony counts in the filtered water were 10,000 times those in tap water.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
28307187-11	1996	prionotes, there was a strong negative correlation between the percentage of water in the stem base of a plant which was derived from the tap root (ground water) and the amount of precipitation which fell at the site.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	138-141
8833348-1	1996	BACKGROUND: This study was designed to determine whether transforming growth factor-alpha (TGF-alpha), epidermal growth factor (EGF), and their common receptor (EGFR) are involved in the recovery of the gastric mucosa after exposure to water immersion and restraint stress.	Water	236-241	epidermal growth factor receptor	Rattus norvegicus	161-165
9206256-2	1996	The experimental results show that it is better to decoct together all the recipe ingredients, with water of pH2 for the first decoction, then water of pH8 for the second decoction, and to make its granularities ranging from the original herbal pieces to particles which can pass through a No.	Water	100-105	polyhomeotic homolog 2	Homo sapiens	109-112
8734306-3	1996	PGE2-stimulated net water flux was also efficiently inhibited in the jejunum and ileum; PYY (ID50 about 10 pmol/kg.h) was 30 to 90 fold more potent than NPY.	Water	20-25	peptide YY	Rattus norvegicus	88-91
8734306-5	1996	CONCLUSIONS: PYY and NPY display potent inhibitory effects of stimulated net water flux at the three studied levels of the small intestine, except in the PGE2-stimulated duodenum.	Water	77-82	peptide YY	Rattus norvegicus	13-16
8734306-6	1996	The PYY ID50s measured suggest that PYY may have a physiological action in regulating small intestinal water flux in the rat.	Water	103-108	peptide YY	Rattus norvegicus	36-39
8555225-0	1996	Selected cysteine point mutations confer mercurial sensitivity to the mercurial-insensitive water channel MIWC/AQP-4.	Water	92-97	aquaporin 4 L homeolog	Xenopus laevis	111-116
8829670-3	1996	A beta-adrenergic activating agent increased the intracellular water content.	Water	63-68	amyloid beta precursor protein	Rattus norvegicus	0-6
8834731-13	1996	Degassed 17 degrees C water produced no visualizable bubbles, while aerated tap water at 43 degrees C showed a high degree of cavitation.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
8603033-7	1996	The mVDR responds effectively to analogs of 1 alpha,25(OH)2D3 which are 6-s-cis locked [e.g. 1 alpha,25(OH)2-previtamin D3 or 1 alpha,25(OH)2-provitamin D3], but these same analogs have only 1-2% of the activity of 1 alpha,25(OH)2D3 in regulating gene transcription.	Water	55-59	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	4-8
8970135-1	1996	The spin-lattice relaxation times of water and hydrocarbon (hexane, benzene) protons in saturated model and natural core plug samples have been measured before and after their hydrophobization.	Water	37-42	spindlin 1	Homo sapiens	4-8
8848877-15	1996	Nunez quoted the large number of his patients cured with Spa water in Antwerp.	Water	61-66	surfactant protein A2	Homo sapiens	57-60
8557080-3	1995	Both the sewage plants SPA and SPB collected domestic and industrial waste, and SPA received drain water from WWA.	Water	99-104	surfactant protein A2	Homo sapiens	80-83
8557088-3	1995	In a case-control study, a strong association between having drunk unboiled tap water from these sources, and a dose-response relationship were found.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
8846844-2	1995	The natriuretic peptides, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are vasodilators with variable effects on electrolyte and water transport at sites such as the nephron.	Water	187-192	natriuretic peptide C	Rattus norvegicus	96-122
8846844-2	1995	The natriuretic peptides, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are vasodilators with variable effects on electrolyte and water transport at sites such as the nephron.	Water	187-192	natriuretic peptide C	Rattus norvegicus	124-127
8808225-2	1995	The contribution of GFR to this change in water and solute excretion has not been quantified in detail.	Water	42-47	Rap guanine nucleotide exchange factor 5	Homo sapiens	20-23
8786662-0	1995	Alterations with age of the T3-stimulated release of atrial natriuretic peptide and its effect on water and sodium metabolism in rats.	Water	98-103	natriuretic peptide A	Rattus norvegicus	53-79
8581489-3	1995	PEG/water induced c-fos in the central core of SFO and PEG/saline induced c-fos in both the central and peripheral regions.	Water	4-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-23
7577950-0	1995	The structural basis for pseudoreversion of the E165D lesion by the secondary S96P mutation in triosephosphate isomerase depends on the positions of active site water molecules.	Water	161-166	triosephosphate isomerase 1	Gallus gallus	95-120
8564432-4	1995	All primates tested to date like sucrose and prefer this sweet substance to tap water.	Water	80-85	nuclear RNA export factor 1	Homo sapiens	76-79
7639439-11	1995	Epidemiologic studies implicated tap water from a physicians" dormitory as the most likely source of the outbreak.	Water	37-42	nuclear RNA export factor 1	Homo sapiens	33-36
7634907-11	1995	With N-CPAP pressures ranging from 5 to 13 cm H2O, all five patients had clinically significant improvement in their symptoms.	Water	46-49	centromere protein J	Homo sapiens	7-11
7481879-12	1995	It is therefore suggested that the administration of ANG II enhances AVP gene transcription in the hypothalamus, especially when water intake is limited.	Water	129-134	angiogenin	Rattus norvegicus	53-56
7624773-2	1995	Those that catalyze the addition of water to alpha, beta-unsaturated thioesters give syn addition-elimination stereochemistry, whereas those that catalyze the addition of water to conjugated carboxylate substrates give anti stereochemistry.	Water	36-41	synemin	Homo sapiens	85-88
7624773-2	1995	Those that catalyze the addition of water to alpha, beta-unsaturated thioesters give syn addition-elimination stereochemistry, whereas those that catalyze the addition of water to conjugated carboxylate substrates give anti stereochemistry.	Water	171-176	synemin	Homo sapiens	85-88
11536679-4	1995	Vapor deposition of hot (300 K) water molecules onto a cold (77 K) substrate yields less porous ices than deposition of cold (77 K) water molecules onto a cold substrate.	Water	32-37	alcohol dehydrogenase iron containing 1	Homo sapiens	20-23
7659789-0	1995	Pregastric and postabsorptive inhibitory effects of water on angiotensin-induced Fos in rat brain.	Water	52-57	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	81-84
7659789-2	1995	It has been reported that the Fos-like immunoreactivity (FLI; a marker of cell activation) that is induced in PVN and SON by exogenous Ang II is prevented by allowing rats to ingest water after injection.	Water	182-187	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-33
7659789-2	1995	It has been reported that the Fos-like immunoreactivity (FLI; a marker of cell activation) that is induced in PVN and SON by exogenous Ang II is prevented by allowing rats to ingest water after injection.	Water	182-187	angiogenin	Rattus norvegicus	135-138
7659789-6	1995	In confirmation of a previous study, rats allowed to drink water after Ang II showed an almost complete absence of FLI in SON and PVN, compared with those not allowed access to water.	Water	59-64	angiogenin	Rattus norvegicus	71-74
7766631-2	1995	Two water-soluble camptothecin derivatives are in clinical trial, and their anticancer activity appears promising: topotecan and CPT-11.	Water	4-9	choline phosphotransferase 1	Homo sapiens	129-132
17020864-2	1995	Upon dilution of the phospholipid stabilised emulsions with a solution of NaT the bile salt became incorporated into the oil/water interface imparting a negative charge to the droplet surface.	Water	125-130	bromodomain containing 2	Homo sapiens	74-77
7721870-11	1995	All nine LCAT mutants retained the ability to hydrolyze the water-soluble PNPB substrate, indicating intact hydrolytic function.	Water	60-65	lecithin-cholesterol acyltransferase	Homo sapiens	9-13
7716769-3	1995	Using a water-soluble source of peroxyl radicals, the azo-initiator 2,2"-azobis(2-aminodinopropane) (AAPH), we found that both PMC and VP-16 are very efficient scavengers of peroxyl radicals as evidenced by their ability to inhibit AAPH-induced chemiluminescence of luminol and oxidation of PnA incorporated into DOPC liposomes.	Water	8-13	host cell factor C1	Homo sapiens	135-140
7704192-2	1995	Tap water samples of 400 ml are saturated with sodium chloride and extracted once with 500 microliters of toluene.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
7657332-6	1995	The correct ABO typing was performed with tissues under the following condition: the tongue and skin immersed in water for 21 days; the tongue treated with heat (100 degrees C) for 40 min; the tongue and skin treated with 0.2mol/L HCl and 0.2 mol/L NaOH for 48 h and the skin treated with 12mol/L HCl and 12mol/L NaOH for 30 min.	Water	113-118	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	12-15
7760704-1	1995	When measuring perfusion by arterial spin labeling, saturation of tissue macromolecular spins during arterial spin labeling greatly decreases tissue water magnetization, reducing the sensitivity of the technique.	Water	149-154	spindlin 1	Rattus norvegicus	37-41
7760704-1	1995	When measuring perfusion by arterial spin labeling, saturation of tissue macromolecular spins during arterial spin labeling greatly decreases tissue water magnetization, reducing the sensitivity of the technique.	Water	149-154	spindlin 1	Rattus norvegicus	88-92
7760704-6	1995	The theory and experiments are presented to estimate tissue perfusion, magnetization transfer rate constants, and spin-lattice relaxation times of water and macromolecular spins in rat brain.	Water	147-152	spindlin 1	Rattus norvegicus	114-118
7890245-6	1995	Water content was increased in brain mass in ET-1-treated rabbits (p = 0.001) suggesting an ET-1-induced edema.	Water	0-5	endothelin-1	Oryctolagus cuniculus	45-49
7890245-6	1995	Water content was increased in brain mass in ET-1-treated rabbits (p = 0.001) suggesting an ET-1-induced edema.	Water	0-5	endothelin-1	Oryctolagus cuniculus	92-96
8643347-6	1995	Hybridization with fibronectin (approximately 7.6kb) and glyceraldehyde-3-phosphate dehydrogenase (1.2kb) revealed that water from a Milli-Q PF water system performed as well as DEPC-treated, autoclaved solutions.	Water	120-125	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	57-97
22823273-5	1995	All cells expressed on their cell surface RT7.2 allotype of CD(45) antigen specific for PVG-RT(7)(b) strain, so that when EAU was induced by adoptive transfer with as little as 5X10(6) cells to PVG-RT(7)(a) recipients, antigen-specific cells of donor allotype (CD(4)(+) RT(7.2)(+)) may be tracked in the recipient (RT(7.1)(+) allotype).	Water	122-125	protein tyrosine phosphatase receptor type C	Homo sapiens	60-74
7990132-11	1994	The solution structure and preferential solvent interactions of hMDH in H2O or 2H2O solvents containing NaCl were studied by densimetry and neutron scattering.	Water	72-75	malate dehydrogenase 2	Homo sapiens	64-68
7952621-7	1994	In contrast, from baseline to 1 mo the NCPAP group experienced a decrease in the frequency of apneas and hypopneas (58.7 +/- 5.2 to 23.2 +/- 6.0/h of sleep, p &lt; 0.001), an increase in mean PtcCO2 (34.6 +/- 1.4 to 40.8 +/- 1.1 mm Hg, p &lt; 0.001), a reduction in mean VI (8.1 +/- 1.0 to 5.2 +/- 0.5 L/min, p &lt; 0.01) and an increase in mean SaO2 (91.6 +/- 1.1 to 95.0 +/- 0.5%, p &lt; 0.025) during stage 2 sleep while on 10.2 +/- 0.5 cm H2O nasal CPAP.	Water	443-446	centromere protein J	Homo sapiens	40-44
7667705-3	1994	During the spontaneous breathing period, the gas flow was high enough to raise a 5-6 cm H2O CPAP level and cause minimal airway pressure fluctuation, an indicator of reduced breathing work.	Water	88-91	centromere protein J	Homo sapiens	92-96
7999055-2	1994	The mucin glycoprotein, purified from canine tracheal mucus, was subjected to mild acid hydrolysis with aqueous acetic acid and autohydrolysis in water, in which approximately 50% drop in the relative viscosity (nr) occurred.	Water	146-151	mucin	Canis lupus familiaris	4-9
7870692-9	1994	Addition of Cd2+ or Hg2+ to the perfusates resulted in decreased jejunal water absorption.	Water	73-78	Cd2 molecule	Rattus norvegicus	12-15
17020832-4	1994	In water, two beta-turn conformations and an extended form were found to be in equilibrium, with cis/trans isomerism at Pro-3.	Water	3-8	pyrroline-5-carboxylate reductase 1	Homo sapiens	120-125
15299369-7	1994	The N atom of Au(CN)(2)(-) is within hydrogen-bonding distance of the zinc-bound H(2)O/OH(-) group which shifts by about 0.4 A away from the zinc ion in relation to its position in the native HCAI.	Water	81-86	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	192-196
7978329-2	1994	The determination of several triazines, organophosphorus pesticides, sulfur containing compounds in tap water was performed by SPE-GC using polymer-packed precolumns and flame ionization (FID), nitrogen-phosphorus (NPD) or flame photometric (FPD) detection.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
7978329-6	1994	Analyte recovery was at least 72% when 10 ml of tap-water sample were analysed.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
7812185-3	1994	For DCCD, AI, NBD-Cl and TNM there is a good correlation between the phase partition in octanol/water and the ability to cross or not the inner mitochondrial membrane.	Water	96-101	teneurin transmembrane protein 1	Homo sapiens	25-28
7919953-1	1994	The simultaneous acquisition of a 4D gradient-enhanced and sensitivity-enhanced [13C,15N]/[15N,15N]-separated NOESY is presented for the 74-residue [13C,15N]-labeled N-terminal SH3 domain of mGrb2 complexed with a peptide fragment from mSOS-2 in 90% H2O.	Water	250-253	growth factor receptor bound protein 2	Mus musculus	191-196
7749388-5	1994	In normotensive rats, we demonstrated that 1) inhibition of NEP potentiates the contribution of kinins to the renal water-sodium metabolism and overcomes the contribution of ANP to that metabolism, 2) nitric oxide participates in the action of kinins, and 3) changes in urinary cGMP excretion do not reflect the changes in plasma ANP, but the changes in nitric oxide, under these conditions.	Water	116-121	membrane metallo-endopeptidase	Rattus norvegicus	60-63
7749388-6	1994	On the other hand, it was also suggested that augmented ANP may contribute mainly to renal water-sodium handling by NEP inhibitor in DOCA-salt rats.	Water	91-96	membrane metallo-endopeptidase	Rattus norvegicus	116-119
8027057-1	1994	The catalysis of the hydration of CO2 by human carbonic anhydrase II (HCA II) includes the transfer of a proton from zinc-bound water to histidine 64 utilizing a network of intervening hydrogen-bonded water molecules, then the proton is transferred to buffer in solution.	Water	128-133	carbonic anhydrase 2	Homo sapiens	47-68
8027057-1	1994	The catalysis of the hydration of CO2 by human carbonic anhydrase II (HCA II) includes the transfer of a proton from zinc-bound water to histidine 64 utilizing a network of intervening hydrogen-bonded water molecules, then the proton is transferred to buffer in solution.	Water	201-206	carbonic anhydrase 2	Homo sapiens	47-68
7970213-2	1994	In contrast, c-fos-positive magnocellular neurons were persistently observed in the SON and PVN of the rats which were chronically stimulated by the drinking of hypertonic NaCl solution instead of water or by water deprivation.	Water	197-202	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
7970213-2	1994	In contrast, c-fos-positive magnocellular neurons were persistently observed in the SON and PVN of the rats which were chronically stimulated by the drinking of hypertonic NaCl solution instead of water or by water deprivation.	Water	209-214	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
7918925-2	1994	RESULTS: beta-lactoglobulin challenge infused into the colonic loop during 30 min reversed the net water flux into a net secretion during the period of antigen infusion.	Water	99-104	beta-lactoglobulin	Bos taurus	9-27
8004320-6	1994	N-CPAP (mc) and face mask CPAP (f-CPAP) resulted in significant dose-dependent decreases of SV-24 +/- 5 ml (21%) and 33 +/- 5 ml (28%), respectively--from baseline to 20 cm H2O (p &lt; 0.05).	Water	173-176	centromere protein J	Homo sapiens	26-30
8004320-6	1994	N-CPAP (mc) and face mask CPAP (f-CPAP) resulted in significant dose-dependent decreases of SV-24 +/- 5 ml (21%) and 33 +/- 5 ml (28%), respectively--from baseline to 20 cm H2O (p &lt; 0.05).	Water	173-176	centromere protein J	Homo sapiens	26-30
8004320-7	1994	HR were unchanged and CO significantly decreased with n-CPAP(mc) and with f-CPAP, 1.6 +/- 0.38 L/min (23%) and 2.29 +/- 0.54 L/min (31%), respectively, from baseline to 20 cm H2O (p &lt; 0.05).	Water	175-178	centromere protein J	Homo sapiens	56-60
8004320-7	1994	HR were unchanged and CO significantly decreased with n-CPAP(mc) and with f-CPAP, 1.6 +/- 0.38 L/min (23%) and 2.29 +/- 0.54 L/min (31%), respectively, from baseline to 20 cm H2O (p &lt; 0.05).	Water	175-178	centromere protein J	Homo sapiens	76-80
7765181-3	1994	Tyrosinase was first immobilized in a thin film of water formed on the inner surface of the membrane and then allowed to catalyze p-cresol oxidation in chloroform.	Water	51-56	tyrosinase	Homo sapiens	0-10
7993588-6	1994	During the accident, study subjects who experienced peculiar taste or odor in the tap water were significantly more in the exposed areas (92% vs. 34.3%).	Water	86-91	nuclear RNA export factor 1	Homo sapiens	82-85
8202947-0	1994	Lead concentration in tap-water and in blood of selected schoolchildren in southern Saxonia.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
8202947-1	1994	In a study of associations between lead in blood and in tap-water, 113 blood samples and 140 tap-water samples of schoolchildren aged 9 to 12 years were analysed.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
8202947-1	1994	In a study of associations between lead in blood and in tap-water, 113 blood samples and 140 tap-water samples of schoolchildren aged 9 to 12 years were analysed.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
8202947-2	1994	Median and maximum values of blood lead were 8.3 and 34.0 micrograms/dl and of lead in tap water 24 and 2600 micrograms/l.	Water	91-96	nuclear RNA export factor 1	Homo sapiens	87-90
8202947-4	1994	The pH values of the tap-water varied from 5.0 to 8.1.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
8202947-5	1994	Both factors involved, i.e., lead pipes and acidic tap-water, have to be amended in order to reduce lead exposure in some regions or locations in Germany.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
8069683-4	1994	These data suggest that ANF may be indirectly involved in the regulation of neuroendocrine processes, behavioral arousal, sexual behavior, water and electrolyte balance, arterial blood pressure, etc., through the modulation of central noradrenergic neurotransmission.	Water	139-144	natriuretic peptide A	Rattus norvegicus	24-27
8071886-6	1994	During the period of fixed water intake, the EGF-treated ewes experienced mild dehydration with elevated plasma osmolality, sodium, renin and arginine vasopressin (AVP) concentrations and slightly reduced plasma atrial natriuretic peptide (ANP) concentrations.	Water	27-32	EGF	Ovis aries	45-48
8071886-8	1994	When the supply of water returned to ad libitum, the EGF-treated ewes increased their water intake by 105% (5.25 +/- 0.28 vs. 2.55 +/- 0.19 l day-1) and subsequently fluid balance was restored; plasma electrolyte and hormone responses also returned to normal.	Water	19-24	EGF	Ovis aries	53-56
8071886-8	1994	When the supply of water returned to ad libitum, the EGF-treated ewes increased their water intake by 105% (5.25 +/- 0.28 vs. 2.55 +/- 0.19 l day-1) and subsequently fluid balance was restored; plasma electrolyte and hormone responses also returned to normal.	Water	86-91	EGF	Ovis aries	53-56
8203597-7	1994	Tsk was controlled with a water-perfused suit covering the entire body except for the head and arms.	Water	26-31	tsukushi, small leucine rich proteoglycan	Homo sapiens	0-3
8181470-5	1994	The relative ability to form an alpha helix, assessed by trifluoroethanol/H2O titration, was found to be Elcatonin &gt; sCT &gt; pCT &gt; eCT &gt; hCT.	Water	74-77	secretin	Homo sapiens	120-123
8181470-6	1994	In Elcatonin, sCT, pCT and eCT the four alpha-helical turns were promoted almost completely in a single step, between 0 and 35% trifluoroethanol, unlike hCT where helical structure formation has been reported to involve two steps over the whole trifluoroethanol/H2O range [Arvinte, T. &amp; Drake, A. F. (1993) J. Biol.	Water	262-265	secretin	Homo sapiens	14-17
7915340-4	1994	Hypertonicity of 490 mOsm/kg.H2O using NaCl reduced both ANP-stimulated guanylate cyclase activity (from 7.7 +/- 1.1 to 4.1 +/- 0.5 fmol/mm/5 min) and cGMP generation (from 1.35 +/- 0.18 to 0.48 +/- 0.20 fmol/mm/3 min) in IMCD.	Water	29-32	natriuretic peptide A	Rattus norvegicus	57-60
7915340-8	1994	In glomeruli, hyperosmolality of 490 mOsm/kg.H2O using NaCl also reduced ANP-stimulated cGMP generation, and hypertonicity of 690 mOsm/kg.H2O using NaCl further reduced it.	Water	45-48	natriuretic peptide A	Rattus norvegicus	73-76
8019847-0	1994	Water-avoidance stress-induced c-fos expression in the rat brain and stimulation of fecal output: role of corticotropin-releasing factor.	Water	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-36
8019847-1	1994	Immunohistochemical detection of the immediate-early gene c-fos was used to determine the pattern of neuronal activity in the rat brain after exposure to water-avoidance stress known to stimulate fecal output in rats.	Water	154-159	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-63
8019847-2	1994	Avoidance to water for 1 h by standing on a small platform increases pellet output and induces numerous Fos-positive cells in the parvocellular part of the paraventricular nucleus of the hypothalamus (PVN), locus coeruleus (LC) and, to a lesser extent, in the bed nucleus of the stria terminalis, lateral septum, dorsal raphe nucleus and A5 and A1 noradrenergic neurons.	Water	13-18	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	104-107
8019847-4	1994	reduced water-avoidance stress-induced c-fos expression mainly in the PVN and the LC (44 and 60%, respectively) and decreased by 60% the stimulated fecal output.	Water	8-13	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-44
8120893-4	1994	On the convex surface, the major groove of the left-handed conformation, water molecules bridge the guanine O-6 keto groups at GpC steps.	Water	73-78	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	108-111
8120893-6	1994	At the bottom of the minor groove, a string of water molecules connects the cytosine O-2 keto groups.	Water	47-52	immunoglobulin kappa variable 1D-39	Homo sapiens	85-88
8064179-1	1994	A water-cooled electromagnetic (EM) dipole, for intracavitary hyperthermia, embodying a metallic reflector to give directional characteristics to the SAR and then to the heating pattern in the biological tissue, is considered.	Water	2-7	sarcosine dehydrogenase	Homo sapiens	150-153
7525832-0	1994	Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel.	Water	76-81	somatostatin	Homo sapiens	0-12
7525832-8	1994	Endogenous somatostatin (eSS-25II) activated net Na+, Cl- and water fluxes across the seawater eel intestine.	Water	62-67	somatostatin	Homo sapiens	11-23
8057971-6	1994	Chlorinated tap-water and table salt ingestion must also be among the environmental factors studied for correlation to HIV infection.	Water	16-21	nuclear RNA export factor 1	Homo sapiens	12-15
8022627-5	1994	Placing the tail in 50 degrees C water before each hindpaw pinch significantly reduced Fos-like immunoreactivity in these regions.	Water	33-38	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	87-90
8012159-0	1994	Water and electrolyte studies during long-term missions onboard the space stations SALYUT and MIR.	Water	0-5	membrane associated ring-CH-type finger 8	Homo sapiens	94-97
24242053-3	1994	quinquefasciatus egg rafts than did the untreated tap water.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
8082218-6	1994	Applying CPAP with the pressure fixed to 6-12 cm H2O can significantly improve hypoventilation index and hypoxemia with lowest SaO2 more than 70% (P &lt; 0.001) and hypoventilation index less than 7 (P &lt; 0.01).	Water	49-52	centromere protein J	Homo sapiens	9-13
8283058-3	1994	EAU-susceptible B10.A mice treated with a mAb to IFN-gamma developed much more severe EAU than did the controls and had increased delayed hypersensitivity (DH) responses to IRBP.	Water	0-3	retinol binding protein 3, interstitial	Mus musculus	173-177
8070028-1	1994	Etoposide phosphate (Etopophos, BMY-40481) is a water-soluble derivative of the widely used podophyllotoxin etoposide (VP-16).	Water	48-53	host cell factor C1	Homo sapiens	119-124
8854898-1	1994	Recently, social concerns regarding tap water quality have increased, mainly because of the possible reduction in safety due to contamination of tap water by various chemicals and more frequent occurrence of the strange odors and tastes in as a result of resource water eutrophication.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
8854898-1	1994	Recently, social concerns regarding tap water quality have increased, mainly because of the possible reduction in safety due to contamination of tap water by various chemicals and more frequent occurrence of the strange odors and tastes in as a result of resource water eutrophication.	Water	149-154	nuclear RNA export factor 1	Homo sapiens	36-39
8142888-0	1994	Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors.	Water	32-37	carbonic anhydrase 2	Homo sapiens	47-68
7505336-1	1993	Two molecular dynamics simulations on bovine pancreatic trypsin inhibitor (BPTI), have been made, one in vacuum, the other in water, in order to assess the effect of the solvent water on collective motions.	Water	178-183	spleen trypsin inhibitor I	Bos taurus	75-79
7505336-8	1993	By assuming the harmonic approximation for the conformational energy surface for BPTI in vacuum to be valid for BPTI in water, and treating each mode as an independent damped oscillator with a friction coefficient of 47 cm-1, the shift to higher frequencies in the water spectrum relative to the vacuum spectrum could be almost exactly reproduced, indicating this shift is due solely to the viscous effect of the solvent.	Water	120-125	spleen trypsin inhibitor I	Bos taurus	81-85
7505336-8	1993	By assuming the harmonic approximation for the conformational energy surface for BPTI in vacuum to be valid for BPTI in water, and treating each mode as an independent damped oscillator with a friction coefficient of 47 cm-1, the shift to higher frequencies in the water spectrum relative to the vacuum spectrum could be almost exactly reproduced, indicating this shift is due solely to the viscous effect of the solvent.	Water	120-125	spleen trypsin inhibitor I	Bos taurus	112-116
7505336-8	1993	By assuming the harmonic approximation for the conformational energy surface for BPTI in vacuum to be valid for BPTI in water, and treating each mode as an independent damped oscillator with a friction coefficient of 47 cm-1, the shift to higher frequencies in the water spectrum relative to the vacuum spectrum could be almost exactly reproduced, indicating this shift is due solely to the viscous effect of the solvent.	Water	265-270	spleen trypsin inhibitor I	Bos taurus	81-85
7505336-8	1993	By assuming the harmonic approximation for the conformational energy surface for BPTI in vacuum to be valid for BPTI in water, and treating each mode as an independent damped oscillator with a friction coefficient of 47 cm-1, the shift to higher frequencies in the water spectrum relative to the vacuum spectrum could be almost exactly reproduced, indicating this shift is due solely to the viscous effect of the solvent.	Water	265-270	spleen trypsin inhibitor I	Bos taurus	112-116
8268155-2	1993	We have reported previously that Cys103 (SHII) of human pancreatic lipase (HPL), unlike the nonessential Cys181 (SHI), was buried and inaccessible to classical water-soluble sulfhydryl reagents.	Water	160-165	pancreatic lipase	Homo sapiens	56-73
8109191-2	1993	High-performance liquid chromatography gel filtration of the water-soluble GH-binding site incubated with 125I-labeled human GH ([125I]hGH) revealed a large peak of bound [125I]hGH eluting at the same position as the peak of [125I]hGH bound to the GHBP in serum.	Water	61-66	growth hormone receptor	Homo sapiens	248-252
8109191-5	1993	The binding affinities for 22,000 hGH and for 20,000 hGH of the serum GHBP were similar to the binding affinity of the water-soluble GH-binding site but lower than those of the cellular GH receptor.	Water	119-124	growth hormone receptor	Homo sapiens	70-74
8109191-6	1993	These findings show that the characteristics of the serum GHBP are comparable to those of the water-soluble GH-binding site released from IM-9 cells and support the hypothesis that in man the serum GHBP is produced by proteolytic cleavage of the cellular GH receptor.	Water	94-99	growth hormone receptor	Homo sapiens	198-202
8308130-2	1993	All Legionella strains isolated from tap water in hospitals could be detected distinctly.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
8303817-8	1993	Minimal dilution of aqueous suspension activated charcoal with tap water greatly increased flow rate through small-bore tubes.	Water	67-72	nuclear RNA export factor 1	Homo sapiens	63-66
8213753-6	1993	After adjustment for cigarette smoking, tap water and coffee consumption, and medical history factors by logistic regression, years of exposure to chlorinated surface water were significantly associated with risk for bladder cancer (p = 0.0007).	Water	167-172	nuclear RNA export factor 1	Homo sapiens	40-43
8214243-0	1993	Preventing tap water scalds: do consumers change their preset thermostats.	Water	15-20	nuclear RNA export factor 1	Homo sapiens	11-14
8395457-9	1993	With head-out water immersion and atrial natriuretic factor infusion, we noted a significant increase in 5" cyclic GMP levels, a second messenger of atrial natriuretic factor, indicating possible activation of atrial natriuretic factor receptors at the inner medullary collecting ducts.	Water	14-19	5'-nucleotidase, cytosolic II	Homo sapiens	115-118
8231819-4	1993	The animals were treated with the crude water extracts of THH (single i.p.	Water	40-45	trichohyalin	Mus musculus	58-61
8397050-2	1993	Previous studies using selective subtype antagonists indicated that opioid effects upon deprivation-induced water intake occurred through the mu2 receptor and that opioid effects upon sucrose intake occurred through kappa and mu2 receptors.	Water	108-113	adaptor related protein complex 2 subunit mu 1	Rattus norvegicus	142-145
7901358-4	1993	infusion of somatostatin (3.5 micrograms/kg stratum plus 3.5 micrograms/kg/h) on the net mucosal flux of salt and water was assessed using an in vivo steady-state perfusion technique.	Water	114-119	somatostatin	Homo sapiens	12-24
8345431-3	1993	At 6 +/- 2 days (mean +/- SD), AGA infants had had significant weight loss (94 +/- 45 gm) and body water loss (67 +/- 80 ml), whereas weight and total body water content in the SGA infants at the same age (5 +/- 1 days) did not differ from the values at birth.	Water	99-104	aspartylglucosaminidase	Homo sapiens	31-34
8345431-4	1993	Loss of weight and total body water in AGA infants was accompanied by a greater diuresis than in SGA infants at the same amount of fluid intake.	Water	30-35	aspartylglucosaminidase	Homo sapiens	39-42
8220437-7	1993	We also tested other mice of both strains for cocaine ingestion in a two-choice test, pairing tap water with 40 mg% cocaine HCl in tap water.	Water	98-103	lymphocyte antigen 6 complex, locus A	Mus musculus	131-134
8220437-7	1993	We also tested other mice of both strains for cocaine ingestion in a two-choice test, pairing tap water with 40 mg% cocaine HCl in tap water.	Water	135-140	lymphocyte antigen 6 complex, locus A	Mus musculus	131-134
24202500-3	1993	Hepatocytes preincubated with 100 - 1000 nM insulin at 15 C bound and internalized less (125)I insulin.We hypothesize that in vivo, at water temperatures of 15 C and higher, extreme physiological levels of plasma insulin may regulate the numbers of insulin receptors in the salmonid liver.	Water	135-140	insulin	Salmo salar	44-51
8389205-8	1993	The lipophilic nitroso spin trap, 2-methyl-2-nitroso propane, which traps a lipid-derived radical, inhibited the low-density lipoprotein modification as did the water-soluble nitroso analog, 2-hydroxymethyl-2-nitroso propane.	Water	161-166	spindlin 1	Homo sapiens	23-27
8504099-8	1993	On the basis of these similarities, yeast AMP deaminase is also proposed to use a Zn(2+)-activated water molecule to attack C6 of AMP with the displacement of NH3.	Water	99-104	AMP deaminase	Saccharomyces cerevisiae S288C	42-55
8333544-1	1993	Although the gastrointestinal peptide cholecystokinin (CCK) has been shown to increase bicarbonate and water secretion and potentiate the effects of secretin on pancreatic ducts, CCK receptors have not been identified on pancreatic ductal epithelium.	Water	103-108	cholecystokinin	Rattus norvegicus	38-53
8333544-1	1993	Although the gastrointestinal peptide cholecystokinin (CCK) has been shown to increase bicarbonate and water secretion and potentiate the effects of secretin on pancreatic ducts, CCK receptors have not been identified on pancreatic ductal epithelium.	Water	103-108	cholecystokinin	Rattus norvegicus	55-58
18965720-9	1993	The new sample introduction system was successfully tested in both a process analysis- and a flow injection analysis mode for the determination of total inorganic carbon in Waco tap water.	Water	182-187	nuclear RNA export factor 1	Homo sapiens	178-181
8333791-4	1993	Tap water included coffee, tea, juices, and glasses of water taken directly from the tap.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
8333791-4	1993	Tap water included coffee, tea, juices, and glasses of water taken directly from the tap.	Water	55-60	nuclear RNA export factor 1	Homo sapiens	0-3
8333791-10	1993	The tap water component was associated with increased risk in both age categories, and there was a clear dose-response relationship.	Water	8-13	nuclear RNA export factor 1	Homo sapiens	4-7
8333791-11	1993	Risks associated with tap water consumption were higher among those who never smoked cigarettes.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
8483366-3	1993	A brief tap water rinse serves to eliminate gross soil of host origin known to interfere with disinfectant efficacy.	Water	12-17	nuclear RNA export factor 1	Homo sapiens	8-11
8321918-1	1993	The aim of this study was to assess the role of arginine-vasopressin (AVP) on extracellular water distribution (VE) and on the urinary excretion of sodium in conscious rabbits with or without water deprivation.	Water	92-97	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	48-68
8321918-1	1993	The aim of this study was to assess the role of arginine-vasopressin (AVP) on extracellular water distribution (VE) and on the urinary excretion of sodium in conscious rabbits with or without water deprivation.	Water	92-97	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	70-73
8321918-9	1993	It is concluded that in adequately hydrated rabbits, pathophysiological plasma levels of AVP shift the water from the VE to the intracellular space and increase the natriuresis, but in partially hydrated rabbits, the infusion of AVP maintains plasma volume constant because of an antidiuretic effect.	Water	103-108	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	89-92
8514695-1	1993	Human hemoglobin (Hb) and Hb cross-linked between the alpha subunits with bis(3,5-dibromosalicyl)fumarate (alpha alpha Hb) were used to treat hemorrhagic shock in water-deprived swine.	Water	163-168	HGB	Sus scrofa	6-16
8479127-9	1993	In a second in vivo study the effect of dialysate from tap water on plasma aluminum using the predialysis purification procedure was evaluated.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
8362013-11	1993	According to the hydrogeologists" estimates, BARBOTAN les thermes, the first European spa with about 22,000 patients is thought to possess enough water to allow from 40,000 to 60,000 people to be treated yearly.	Water	146-151	surfactant protein A2	Homo sapiens	86-89
8457854-3	1993	We observed that increased hippocampal choline acetyltransferase activity was related to better performance on the water maze task, and that, of the individual measures, hippocampal choline acetyltransferase activity was the best predictor of behavioral performance in the spatial learning task.	Water	115-120	choline O-acetyltransferase	Rattus norvegicus	39-64
8457854-3	1993	We observed that increased hippocampal choline acetyltransferase activity was related to better performance on the water maze task, and that, of the individual measures, hippocampal choline acetyltransferase activity was the best predictor of behavioral performance in the spatial learning task.	Water	115-120	choline O-acetyltransferase	Rattus norvegicus	182-207
8431497-0	1993	Reaction of lecithin: cholesterol acyltransferase with a water soluble substrate: effects of surfactants.	Water	57-62	lecithin-cholesterol acyltransferase	Homo sapiens	12-49
8321519-4	1993	The nonfreezable water content of the polymerized vimentin is higher than that of the monomeric vimentin.	Water	17-22	vimentin	Bos taurus	50-58
7764229-2	1993	Both extensin precursor and extensin peroxidase were ionically eluted from intact water-washed tomato (hybrid of Lycopersicon esculentum Mill.	Water	82-87	extensin-3-like	Solanum lycopersicum	5-13
7764229-2	1993	Both extensin precursor and extensin peroxidase were ionically eluted from intact water-washed tomato (hybrid of Lycopersicon esculentum Mill.	Water	82-87	extensin-3-like	Solanum lycopersicum	28-36
8362459-3	1993	A field study found that BCG syringes, which had their rubber seals replaced once, could be used at least 150 times, and DPT syringes more than 200 times even when sterilized in tap water with a hardness of 88 mg calciumoxyde per liter.	Water	182-187	nuclear RNA export factor 1	Homo sapiens	178-181
1471688-1	1992	OBJECTIVE: In sheep, maternal water deprivation results in urinary natriuresis in spite of suppression of plasma atrial natriuretic factor levels.	Water	30-35	natriuretic peptides A	Ovis aries	113-138
1479295-0	1992	Continuous fluorescence assay for lecithin:cholesterol acyltransferase using a water-soluble phosphatidylcholine.	Water	79-84	lecithin-cholesterol acyltransferase	Homo sapiens	34-70
1479295-1	1992	A water-soluble fluorescent phosphatidylcholine, 1,2-bis[4-(1-pyreno-butanoyl]-sn-glycero-3-phosphocholine (DPybPC) has been used to develop a sensitive, continuous assay for pure lecithin:cholesterol acyltransferase (LCAT) in solution.	Water	2-7	lecithin-cholesterol acyltransferase	Homo sapiens	180-216
1479295-1	1992	A water-soluble fluorescent phosphatidylcholine, 1,2-bis[4-(1-pyreno-butanoyl]-sn-glycero-3-phosphocholine (DPybPC) has been used to develop a sensitive, continuous assay for pure lecithin:cholesterol acyltransferase (LCAT) in solution.	Water	2-7	lecithin-cholesterol acyltransferase	Homo sapiens	218-222
1429693-8	1992	The variation of these Kd values with FA molecular species is highly correlated with the solubility of the FA in water, suggesting that all these FA bind with a similar conformation in the I-FABP binding site.	Water	113-118	fatty acid binding protein 2	Rattus norvegicus	189-195
1416971-11	1992	Complex formation between the NADPH-cytochrome P450 reductase and cytochrome P450 LM2 monomers was not detected by recording the difference binding spectra of the reductase monomers with LM2 monomers or by treatment the mixture of the monomers of the proteins with the crosslinking reagent, water-soluble carbodiimide.	Water	291-296	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	30-61
1331121-6	1992	This PAF-stimulated elevation in 3H-water soluble phosphorylbases was seen at 5 min but not at 15 sec suggesting that the initial rise in DAG as well as the initial elevation in [Ca2+]i are due primarily to PtdIns-4,5-P2 hydrolysis.	Water	36-41	PCNA clamp associated factor	Rattus norvegicus	5-8
1433198-1	1992	The 15-residue apolar peptide, Boc-Val-Ala-Leu-Aib-Val-Ala-Leu-(Val-Ala-Leu-Aib)2-OMe has been crystallized from 2-propanol-water (form I).	Water	124-129	ANIB1	Homo sapiens	47-50
1456205-3	1992	To differentiate between aerosol generated during the free fall and at the end of the fall, the slug was dropped either onto a flat surface or into a container of water that suppressed dust generation associated with the impact at the end of the fall.	Water	163-168	snail family transcriptional repressor 2	Homo sapiens	96-100
1432622-4	1992	The values obtained could be correlated with the values for n-octanol-water partition taken from the literature by an approach based on the linear solvation relationship: log P1 = a log P2 + b; in this relationship, a and b are constants and P1 and P2 correspond to the two different organic and aqueous phase partition equilibria.	Water	70-75	crystallin gamma F, pseudogene	Homo sapiens	242-251
1441760-2	1992	Aflatoxins B1, B2, G1, and G2, are extracted by methanol/water (85 + 15) and partitioned into methylene dichloride.	Water	57-62	anthocyanin regulatory R-S protein-like	Zea mays	11-29
1279356-2	1992	A component with long T1 and T2 (T1,1 and T2,1) is associated with a large water fraction alpha 1,1 and alpha 2,1 and a component with short T1 and T2 (T1,2 and T2,2) with a small water fraction alpha 1,2 and alpha 2,2.	Water	75-80	solute carrier family 25 member 5	Homo sapiens	29-31
1279356-2	1992	A component with long T1 and T2 (T1,1 and T2,1) is associated with a large water fraction alpha 1,1 and alpha 2,1 and a component with short T1 and T2 (T1,2 and T2,2) with a small water fraction alpha 1,2 and alpha 2,2.	Water	75-80	solute carrier family 25 member 5	Homo sapiens	42-44
1279356-2	1992	A component with long T1 and T2 (T1,1 and T2,1) is associated with a large water fraction alpha 1,1 and alpha 2,1 and a component with short T1 and T2 (T1,2 and T2,2) with a small water fraction alpha 1,2 and alpha 2,2.	Water	75-80	solute carrier family 25 member 5	Homo sapiens	42-44
1279356-2	1992	A component with long T1 and T2 (T1,1 and T2,1) is associated with a large water fraction alpha 1,1 and alpha 2,1 and a component with short T1 and T2 (T1,2 and T2,2) with a small water fraction alpha 1,2 and alpha 2,2.	Water	180-185	solute carrier family 25 member 5	Homo sapiens	29-31
1449959-1	1992	MRS defines the molecular state of water, the chemical environment of cells and tissues and the qualitative and quantitative state of intermediary metabolism.	Water	35-40	MROS	Homo sapiens	0-3
1639611-5	1992	Thus, EAU induced by R16 at a dose of 0.2 nmol/rat was inhibited completely in all rats treated with the peptide at doses of 400 or 133 nmol and partially by the low dose of 5 nmol/rat.	Water	6-9	ribonuclease 16-like	Rattus norvegicus	21-24
1403728-0	1992	In vitro and in vivo release of poly(DL-lactic acid) microspheres containing neurotensin analogue prepared by novel oil-in-water solvent evaporation method.	Water	123-128	neurotensin	Rattus norvegicus	77-88
1605643-6	1992	When partial DNA sequencing of the regions downstream of the NQO3 gene was performed, sequences homologous to the mitochondrial ND-1, ND-5, and ND-2 gene products of bovine complex I were found, suggesting that the gene cluster carrying the Paracoccus NADH dehydrogenase complex contains not only structural genes encoding water-soluble subunits but also structural genes encoding hydrophobic subunits.	Water	323-328	NADH dehydrogenase subunit 1	Bos taurus	128-132
1321099-4	1992	The 3He detection limit of the system is close to 10(-16) cm3 STP corresponding to a tritium level of 0.003 TU for a 500 g water sample stored six months for 3He regrowth.	Water	123-128	thyroid hormone receptor interactor 10	Homo sapiens	62-65
1356466-7	1992	RESULTS: The infection rate in wounds cleaned with sterile saline was 10.3% compared with 5.4% in wounds cleaned with tap water (p less than 0.05).	Water	122-127	nuclear RNA export factor 1	Homo sapiens	118-121
1625612-3	1992	RESULTS: The contents of 106 aluminium cans and bottles representing 52 different beverages all had a higher aluminium content than Newcastle tap water at 1.4 mumol/L, ranging as high as 385 mumol/L.	Water	146-151	nuclear RNA export factor 1	Homo sapiens	142-145
1566827-3	1992	PRL increases the apparent maximum velocity of AIB uptake from 0.16 to 0.43 nmol.l intracellular water-1.min-1.	Water	97-102	prolactin	Mus musculus	0-3
1593773-0	1992	[Bio- and histochemical changes of tissue kallikrein in the rat stomach after water immersion-induced gastric ulcer].	Water	78-83	kallikrein 1-related peptidase C12	Rattus norvegicus	35-52
1593773-5	1992	Water-immersion stress significantly decreased total tissue kallikrein at Stage IV of ulcers compared with the control value (p less than 0.001 in both measuring methods).	Water	0-5	kallikrein 1-related peptidase C12	Rattus norvegicus	53-70
1347994-7	1992	CNP may play an important role in the regulation of water and electrolyte movements across the blood brain barrier.	Water	52-57	natriuretic peptide C	Rattus norvegicus	0-3
1312606-1	1992	The initial water proteolysis step in the proton transfer "half-reaction" of human carbonic anhydrase I is simulated using the empirical valence bond method in combination with free energy perturbation molecular dynamics calculations.	Water	12-17	carbonic anhydrase 1	Homo sapiens	83-103
1558208-2	1992	In contrast, water intakes following acute administration of ANG II were comparable in the two strains.	Water	13-18	angiogenin	Rattus norvegicus	61-64
1558208-5	1992	In two of three studies, water intake after acute peripheral administration of either ANG I or the beta-adrenergic agonist isoproterenol did not differ between strains; in one study, the response to both dipsogens was lower in F344 rats.	Water	25-30	angiogenin	Rattus norvegicus	86-89
1627273-8	1992	The SOD mimetic activity of PS-K resisted treatment by 0.7N HCl, 0.7N NaOH, boiling for 30 minutes in a double water bath, and digestion by pronase.	Water	111-116	TAO kinase 2	Homo sapiens	28-32
1302047-2	1992	An increase in GAST1 RNA levels is detectable 2 h after treatment and levels continue to increase for at least an additional 10 h. Between 12 and 24 h following treatment, the amount of GAST1 RNA begins to decline and at 48 h the level is nearly equivalent to that of water-treated control plants.	Water	268-273	protein GAST1	Solanum lycopersicum	15-20
1574621-1	1992	We fit lognormal distributions to data collected in a national survey for both total water intake and tap water intake by children and adults for these age groups in years: 0 less than age less than 1; 1 less than or equal to age less than 11; 11 less than or equal to age less than 20; 20 less than or equal to age less than 65; 65 less than or equal to age; and all people in the survey taken as a single group.	Water	106-111	nuclear RNA export factor 1	Homo sapiens	102-105
1370631-5	1992	Osmotic water permeability (Pf, in centimeters per second; n = 4) averaged 0.0012 +/- 0.00033 in lipid LUV, 0.0032 +/- 0.0015 in Glut1 LUV, and 0.006 +/- 0.0014 in ghost LUV.	Water	8-13	solute carrier family 2 member 1	Homo sapiens	129-134
1737576-0	1992	Peptide YY enhances NaCl and water absorption in the rat colon in vivo.	Water	29-34	peptide YY	Rattus norvegicus	0-10
1737576-3	1992	The effect of PYY on electrolyte and water transport in the rat colon was studied in vivo.	Water	37-42	peptide YY	Rattus norvegicus	14-17
1737576-5	1992	Intravenous administration of PYY produced a dose-dependent increase in the net absorption of sodium chloride and water, as well as a decrease in the net secretion of potassium.	Water	114-119	peptide YY	Rattus norvegicus	30-33
1737576-6	1992	PYY inhibited the reduction in net absorption of sodium chloride and water evoked by vasoactive intestinal peptide (VIP), but did not affect the VIP-evoked increase in net potassium secretion.	Water	69-74	peptide YY	Rattus norvegicus	0-3
1340096-1	1992	Atypical Mycobacteria were demonstrated in tap water.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
1577835-6	1992	All of the high-water copolymer compositions developed resulted in lysozyme uptake typical of nonionic high-water-content hydrogels and oxygen permeability levels greater than 50 (cm3-O2(STP).cm)/(s.cm2.mm Hg) x 10(-11).	Water	16-21	thyroid hormone receptor interactor 10	Homo sapiens	187-190
1401336-1	1992	Eel atrial natriuretic peptide inhibited the serosa-negative transepithelial potential difference and short-circuit current, accompanied by a decrease in NaCl and water absorption across the seawater eel intestine.	Water	163-168	natriuretic peptide A	Rattus norvegicus	4-30
1351969-3	1992	Documented effects of beta 2-adrenergic receptor activation in the human lung include smooth muscle relaxation, inhibition of acetylcholine release from cholinergic nerve terminals, stimulation of serous and mucous cell secretion, increases in ciliary beat frequency, promotion of water movement into the airway lumen by stimulation of ion secretion across the apical membrane of epithelial cells, increase in bronchial blood flow, reduction in venular permeability, and inhibition of mediator release from some, but not all, inflammatory cells.	Water	281-286	adrenoceptor beta 2	Homo sapiens	22-48
1406054-6	1992	Distention of the antral sleeve by hydrostatic pressure (3-25cm H2O) caused stepwise and significant increase in gastrin release that was reversible.	Water	64-67	gastrin	Rattus norvegicus	113-120
1752300-3	1991	A case-control study demonstrated a strong statistical association between illness and the consumption of unboiled tap water from a particular source, with evidence of a dose-response relationship.	Water	119-124	nuclear RNA export factor 1	Homo sapiens	115-118
1752966-0	1991	Water deprivation stimulates transforming growth factor-beta 2 accumulation in the juxtaglomerular apparatus of mouse kidney.	Water	0-5	hemoglobin, beta adult minor chain	Mus musculus	56-62
1836070-1	1991	Although associated primarily with the cardiovascular system, atrial natriuretic factor (ANF) has been found to increase the magnitude of duodenal contractions and may play a role in salt and water absorption across gastrointestinal epithelium.	Water	192-197	natriuretic peptide A	Rattus norvegicus	62-87
1836070-1	1991	Although associated primarily with the cardiovascular system, atrial natriuretic factor (ANF) has been found to increase the magnitude of duodenal contractions and may play a role in salt and water absorption across gastrointestinal epithelium.	Water	192-197	natriuretic peptide A	Rattus norvegicus	89-92
1657994-3	1991	When acini were incubated with [3H]choline in the presence of 1 nM CCK-octapeptide (CCK8) for 60 min, the incorporations of [3H]choline into both water-soluble choline metabolites and PC in acini were reduced by CCK8 to 74 and 41% of control, respectively.	Water	146-151	cholecystokinin	Rattus norvegicus	67-70
1838019-0	1991	Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose.	Water	64-69	natriuretic peptide A	Rattus norvegicus	0-26
1838019-1	1991	Recent evidence predicts an effect of atrial natriuretic peptide (ANP) on the blood-brain transfer of water.	Water	102-107	natriuretic peptide A	Rattus norvegicus	38-64
1939111-6	1991	The hydrogen atom at C-3 of the enzyme product is introduced from solvent water.	Water	74-79	complement C3	Homo sapiens	21-24
1802860-5	1991	These data suggest that in "metal free" water, native PRG could contain several small poly-L-proline II helices along with beta- and/or gamma-turns.	Water	40-45	proline rich protein BstNI subfamily 3	Homo sapiens	54-57
1665892-1	1991	Spin-lattice relaxation rates of water protons in hydrated immobilized lysozyme are measured as a function of magnetic field strength.	Water	33-38	spindlin 1	Homo sapiens	0-4
1792500-10	1991	Reabsorption of water and electrolytes in the bile ducts and in the gallbladder, and secretion of bicarbonate by the bile ducts, stimulated by secretin.	Water	16-21	secretin	Homo sapiens	143-151
1888740-8	1991	Surprisingly, the hydrogen bond to the -NH2 group in mMDH is the same as that found for water.	Water	88-93	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	53-57
1679605-5	1991	Inhibition of glutamine synthetase activity by pretreatment with L-methionine sulfoximine prevented both the increase in brain glutamine levels and the increase in brain water content despite elevated plasma ammonium levels (908 +/- 196 mumol/l).	Water	170-175	glutamate-ammonia ligase	Rattus norvegicus	14-34
1839321-3	1991	The plasma concentration of ANP decreased in water deprived rats, and the ANP mRNA levels in both auricles of these rats were lower than those of the control, particularly in the left auricle.	Water	45-50	natriuretic peptide A	Rattus norvegicus	28-31
1715187-4	1991	The investigation of pH-dependences of both the conductance and the cation-anion selectivity of the CT-B channel allowed us to suggest that the water pore of this channel is confined to the B-subunit of cholera toxin.	Water	144-149	phosphate cytidylyltransferase 1B, choline	Homo sapiens	100-104
1715187-5	1991	The effective diameter of the CT-B channels water pores was directly measured in BLM and is equal to 2.1 +/- 0.2 nm.	Water	44-49	phosphate cytidylyltransferase 1B, choline	Homo sapiens	30-34
1758973-2	1991	CCK immunoreactivity in water extract of cerebral cortex of LEC rats with hepatic encephalopathy (n = 7) was 41.5 +/- 2.6 (mean +/- S.E.M.	Water	24-29	cholecystokinin	Rattus norvegicus	0-3
1654867-3	1991	The objectives of this study were to assess the overall potencies of PCB-containing extracts from colonial water-bird eggs taken from the Great Lakes and to compare the potencies with the location and spatial distribution of the colonies.	Water	107-112	pyruvate carboxylase	Rattus norvegicus	69-72
1832749-1	1991	Although synthetic atrial natriuretic polypeptide (ANP) is known to influence the water and electrolyte metabolism and arginine-8-vasopressin (AVP) secretion, the physiological role of endogenous ANP in the rat brain is still unclear.	Water	82-87	natriuretic peptide A	Rattus norvegicus	19-49
1832749-1	1991	Although synthetic atrial natriuretic polypeptide (ANP) is known to influence the water and electrolyte metabolism and arginine-8-vasopressin (AVP) secretion, the physiological role of endogenous ANP in the rat brain is still unclear.	Water	82-87	natriuretic peptide A	Rattus norvegicus	51-54
1832749-4	1991	The icv administration of the h-ANP antiserum significantly increased the spontaneous water intake, urine output and urinary potassium excretion in rats given water ad libitum.	Water	86-91	natriuretic peptide A	Rattus norvegicus	32-35
1832749-4	1991	The icv administration of the h-ANP antiserum significantly increased the spontaneous water intake, urine output and urinary potassium excretion in rats given water ad libitum.	Water	159-164	natriuretic peptide A	Rattus norvegicus	32-35
2058746-1	1991	We have investigated the rapid changes in plasma prolactin and arginine vasopressin (AVP) associated with water satiation in ruminants.	Water	106-111	vasopressin-neurophysin 2-copeptin	Ovis aries	85-88
1673747-2	1991	Of 240 guests surveyed, 110 had a gastrointestinal illness that was significantly associated with the drinking of tap water from the resort"s well (relative risk = 16.1, 95% confidence interval 14.5 to 17.8) and this risk increased significantly with the number of glasses of water consumed (p less than 0.005).	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
2006162-3	1991	125I-Ang can be crosslinked efficiently to AngBP by a water-soluble carbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbo-diimide.	Water	54-59	ANG	Bos taurus	5-8
2002506-3	1991	assignment of 49 of the 51 amino acid residues of human B9(Asp) insulin in water at low pH is reported.	Water	75-80	NADH:ubiquinone oxidoreductase subunit A3	Homo sapiens	56-71
1892613-1	1991	The degradation of a new semisynthetic polyene antibiotic partricin A dimethylamino ethylamide diaspartate (SPA-S-717) at 37 degrees C in water at different pH is studied.	Water	138-143	surfactant protein A2	Homo sapiens	108-111
2059420-1	1991	Experiments were performed to measure the transfer of trichloroethylene (TCE), a volatile organic compound (VOC), from tap water in showers to indoor air.	Water	123-128	nuclear RNA export factor 1	Homo sapiens	119-122
2059420-2	1991	In these experiments, the loss of TCE from tap water in the shower is based on the difference between influent and effluent concentrations.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
1808977-3	1991	All the animals were given normal rat chow and drinking water following the injection of crude gastrin.	Water	56-61	gastrin	Rattus norvegicus	95-102
1664324-3	1991	The spin labels are regarded as models for long amino acid side chains and as probes for the dynamics of protein and water in the vicinity of the protein surface.	Water	117-122	spindlin 1	Homo sapiens	4-8
2005005-6	1991	Piglets choosing among birth fluids, sow"s milk or tap water during a 5-min test spent more time with maternal odors than with water (P less than .05).	Water	55-60	nuclear RNA export factor 1	Homo sapiens	51-54
2022688-0	1991	Tap-water scald burns.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
2022688-2	1991	Review of admissions to a regional burn center showed that tap-water burns were an injury of pediatric, elderly, and neurologically impaired patients.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
2022688-4	1991	All those surveyed realized the potential for tap-water scald burns in their homes, and few believed that they could tolerate hot-only tap water at home for as long as 30 seconds.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
2022688-5	1991	Respondents who had previous experience with tap-water burns had not lowered the settings of their water-heater thermostats.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
2291847-0	1990	An analytical method to determine Henry"s law constant for selected volatile organic compounds at concentrations and temperatures corresponding to tap water use.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
2255881-4	1990	In one case we observed "jelly-like crystals" of about 2 mm diameter which dissolved spontaneously in tap water.	Water	106-111	nuclear RNA export factor 1	Homo sapiens	102-105
2255881-6	1990	"Jelly-like crystals" developed in our laboratory when the absorbent material of the new diapers was put in contact with urine or tap water.	Water	134-139	nuclear RNA export factor 1	Homo sapiens	130-133
2221578-4	1990	Lung volumes at 10 cm H2O on deflation curves increased in a dose-dependent fashion at concentrations of SP-A between 0.5 and 5% by weight with no further improvement at 10% SP-A, although the volumes were significantly lower than for natural surfactant.	Water	22-25	pulmonary surfactant-associated protein A	Oryctolagus cuniculus	105-109
2122273-2	1990	In rats, 4 to 5 weeks after extensive unilateral or bilateral craniectomy and opening of the dura, a 50-mOsm/kg decrease in plasma osmolality was produced by systemic administration of distilled water ("water intoxication"), or a 28-mOsm/kg increase in plasma osmolality was produced by systemic administration of either 1 M NaCl or 1 M mannitol in 0.34 M NaCl.	Water	195-200	oncostatin M	Mus musculus	104-108
1703224-1	1990	The induction of experimental allergic encephalomyelitis (EAE) with purified myelin basic protein (MBP) has, heretofore, required its incorporation in a water-in-oil emulsion or adsorption on particulate adjuvants.	Water	153-158	myelin basic protein	Rattus norvegicus	77-97
1703224-1	1990	The induction of experimental allergic encephalomyelitis (EAE) with purified myelin basic protein (MBP) has, heretofore, required its incorporation in a water-in-oil emulsion or adsorption on particulate adjuvants.	Water	153-158	myelin basic protein	Rattus norvegicus	99-102
1974931-3	1990	From computer graphics analysis and MD simulations on the zinc hydroxide form of human carbonic anhydrase II we find that this interaction forces the hydroxide hydrogen atom to be in a "down" position relative to the deep water-binding pocket.	Water	222-227	carbonic anhydrase 2	Homo sapiens	87-108
2386243-4	1990	In addition, both peptides increased water intake when food was present but not when food was absent, suggesting that a neural substrate supporting a direct action of NPY and PYY on water intake is not present in the hindbrain.	Water	182-187	peptide YY	Rattus norvegicus	175-178
2395338-0	1990	Influence of storage conditions on aluminum concentrations in serum, dialysis fluid, urine, and tap water.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
2395338-6	1990	Frozen storage was superior compared with 4 degrees C, whereas storage at -80 degrees C offered no advantage compared with storage at -20 degrees C. Acidification of tap water samples was necessary to stabilize Al levels during storage.	Water	170-175	nuclear RNA export factor 1	Homo sapiens	166-169
2168528-1	1990	Increasing evidence suggests that atrial natriuretic peptide (ANP), a 28 amino acid peptide with biologically active 4-28 and 5-28 congeners, modulates salt-water homeostasis at both peripheral and central levels.	Water	157-162	natriuretic peptide A	Rattus norvegicus	34-60
2168528-1	1990	Increasing evidence suggests that atrial natriuretic peptide (ANP), a 28 amino acid peptide with biologically active 4-28 and 5-28 congeners, modulates salt-water homeostasis at both peripheral and central levels.	Water	157-162	natriuretic peptide A	Rattus norvegicus	62-65
2369399-4	1990	Rectal temperatures were higher, and their relative change from baseline (delta Tre) smaller, for 3 of the 5 subjects at minute 122 in the water than in the raft.	Water	139-144	tRNA-Glu (anticodon TTC) 3-1	Homo sapiens	80-83
2303058-1	1990	The conformation of bombesin in trifluoroethanol/water mixtures has been studied using 1H-NMR spectroscopy.	Water	49-54	gastrin releasing peptide	Homo sapiens	20-28
2301865-6	1990	Patients with malignant external otitis had a statistically significant higher incidence of aural irrigation with tap water when compared with control subjects.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
1972840-3	1990	Skin hydration was changed by soaking skin with tap water.	Water	52-57	nuclear RNA export factor 1	Homo sapiens	48-51
2165464-6	1990	Finally, [Pro7] NKB, which completely discriminates NK-2 and NK-3 binding sites, is a water-soluble NK-3 selective agonist.	Water	86-91	NK3 homeobox 1	Homo sapiens	100-104
1983007-7	1990	Intravenous infusion of atrial natriuretic factor produced hypotension, bradycardia and an increase in sodium and water excretion.	Water	114-119	natriuretic peptide A	Rattus norvegicus	24-49
2139163-0	1990	Atrial natriuretic factor in central nervous system regulatory mechanisms: effect of experimental alterations in water and salt homeostasis and blood pressure.	Water	113-118	natriuretic peptide A	Rattus norvegicus	0-25
2934736-3	1985	The recent description of ANF-like immunoreactivity in brain regions associated with the control of water intake suggested a role for these peptides in the neurogenic mechanisms of thirst.	Water	100-105	natriuretic peptide A	Rattus norvegicus	26-29
2934736-4	1985	Intracerebroventricular (third ventricle) infusion of 1.0 or 2.0 nmol of ANF in conscious, overnight-dehydrated rats significantly inhibited subsequent water intake over a 2-hr test period.	Water	152-157	natriuretic peptide A	Rattus norvegicus	73-76
2934736-5	1985	Intravenous infusion of 2.0 nmol, but not 1.0 nmol, of ANF resulted in a similar inhibitory action, suggesting that ANF released from the heart might act centrally to inhibit water intake by an action at one or more of the circumventricular organs.	Water	175-180	natriuretic peptide A	Rattus norvegicus	116-119
2934736-6	1985	Water intake induced by central infusion of angiotensin II (9.6 and 25 pmol) in normally hydrated rats was significantly inhibited by prior infusion of 2.0 nmol of ANF.	Water	0-5	natriuretic peptide A	Rattus norvegicus	164-167
2934736-8	1985	These results indicate a possible physiologic role for ANF in the hypothalamic control of water intake and reveal that the cardiac peptides can act centrally, as well as peripherally, to assist in the normalization of extracellular fluid volume.	Water	90-95	natriuretic peptide A	Rattus norvegicus	55-58
33770867-1	2021	Identifying the eco-hydrological processes associated with water-salt dynamics is important for the sustainable management of water resources and eco-environmental systems in groundwater-dependent ecosystems, especially across different land use types in salt-affected oasis-desert ecosystems.	Water	59-64	cAMP responsive element binding protein 3 like 1	Homo sapiens	269-274
33770867-11	2021	Adaptive management of water and salt migration in soil and groundwater is essential for maintaining the coexistence of oasis-desert ecosystems in arid areas.	Water	23-28	cAMP responsive element binding protein 3 like 1	Homo sapiens	120-125
33824405-7	2021	The present multifaceted experimental study, complemented by homology modelling and molecular dynamics simulations, resolves a long-standing controversy about the taste of heavy water, shows that its sweet taste is mediated by the human TAS1R2/TAS1R3 taste receptor, and opens way to future studies of the detailed mechanism of action.	Water	178-183	taste 1 receptor member 2	Homo sapiens	237-243
33794341-1	2021	Water transport in the brain is tightly controlled by blood-brain-barrier (BBB) composed of capillary endothelial cells expressing AQP1/AQP11 and glial foot processes expressing AQP4.	Water	0-5	aquaporin 4	Mus musculus	178-182
33805237-5	2021	A cut-off CV mode, which was operated to maximize Ca2+ removal efficiency per cycle, was found to lead to a specific energy consumption (SEC) of 0.061 kWh/mole removed Ca2+ for partially softening industrial water and 0.077 kWh/m3 removed Ca2+ for slightly softening tap water at a water recovery of 0.5.	Water	208-213	nuclear RNA export factor 1	Homo sapiens	267-270
33820314-4	2021	The attenuation coefficient of tap water is 0.08/m, which is close to Jerlov Type II seawater.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
33800074-8	2021	This is the first study to show that mungbean water extract increased cellular glucose uptake and improved insulin sensitivity of insulin-resistant HepG2 cells through PTP-1B inhibition and modulating the expression of genes related to glucose metabolism.	Water	46-51	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	168-174
33806644-5	2021	The samples incorporating metakaolin showed the highest compressive strength of 76.60 MPa at 90 days tap water curing and this was 17% higher than that of the control.	Water	105-110	nuclear RNA export factor 1	Homo sapiens	101-104
33236627-0	2021	Electrocatalytic Water Oxidation by a Phosphorus-Nitrogen O PN3-Pincer Cobalt Complex.	Water	17-22	sodium voltage-gated channel alpha subunit 10	Homo sapiens	60-63
26076067-6	2015	The differences in hydrophobicity of CH2 and CF2 units in water and liquid ammonia are discussed, as is the possible relevance to life forms in liquid ammonia.	Water	58-63	ATPase H+ transporting accessory protein 1	Homo sapiens	45-48
23744739-4	2013	The present study examined 1) changes in the distribution of intestinal anion transporters and the aquaporin 5 (AQP5) water channel in rat Brunner"s glands following second messenger activation and 2) anion transporter distribution in Brunner"s glands from healthy and disease-affected human tissues.	Water	118-123	aquaporin 5	Rattus norvegicus	99-110
23744739-4	2013	The present study examined 1) changes in the distribution of intestinal anion transporters and the aquaporin 5 (AQP5) water channel in rat Brunner"s glands following second messenger activation and 2) anion transporter distribution in Brunner"s glands from healthy and disease-affected human tissues.	Water	118-123	aquaporin 5	Rattus norvegicus	112-116
18438635-8	2008	Among the cathodic electrolyte tested, these can be listed in decreasing order of power density as aerated KMnO(4) solution &gt; KMnO(4) solution without aeration &gt; aerated tap water &gt; aerated tap water with NaCl.	Water	180-185	nuclear RNA export factor 1	Homo sapiens	176-179
11978492-7	2002	Some antioxidant enzymes were also analyzed in RBCs, including glucose-6-phosphate dehydrogenase (G6PD), which provides the RBC"s main reducing power, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and catalase detoxifies H2O2 by catalyzing its reduction to O2 and H2O.	Water	236-239	glucose-6-phosphate dehydrogenase	Homo sapiens	98-102
8771178-7	1995	In monoclinic H94D CAII, a fully occupied zinc ion is tetrahedrally coordinated by D94, H96, H119 and a water molecule.	Water	104-109	carbonic anhydrase 2	Homo sapiens	19-23
12228608-5	1995	Upon imbibition of water, the number of cells in G2 started to increase after 24 h, and a 55-kD [beta]-tubulin signal was detected between 24 and 48 h. Two-dimensional immunoblots revealed at least three different [beta]-tubulin isotypes.	Water	19-24	beta-tubulin	Solanum lycopersicum	97-110
12228608-5	1995	Upon imbibition of water, the number of cells in G2 started to increase after 24 h, and a 55-kD [beta]-tubulin signal was detected between 24 and 48 h. Two-dimensional immunoblots revealed at least three different [beta]-tubulin isotypes.	Water	19-24	beta-tubulin	Solanum lycopersicum	215-228
34800573-6	2022	Our main explanatory variable was the tap water lithium level (Li) from public drinking water supply systems using their own water source (n = 1 325).	Water	42-47	nuclear RNA export factor 1	Homo sapiens	38-41
34800573-6	2022	Our main explanatory variable was the tap water lithium level (Li) from public drinking water supply systems using their own water source (n = 1 325).	Water	88-93	nuclear RNA export factor 1	Homo sapiens	38-41
34800573-6	2022	Our main explanatory variable was the tap water lithium level (Li) from public drinking water supply systems using their own water source (n = 1 325).	Water	125-130	nuclear RNA export factor 1	Homo sapiens	38-41
34562756-5	2022	Total PFAS concentrations up to 242 ng L-1 (average of 168 ng L-1) were found in tap water from Grapeland Heights, which is the closest location to the Miami international airport that was sampled.	Water	85-90	nuclear RNA export factor 1	Homo sapiens	81-84
34562756-7	2022	In general, average total PFAS was higher in tap water (86.3 ng L-1) than in surface waters (46.3 ng L-1), whereas the most predominant and frequently detected PFAS were PFBA, PFBS, PFPeA, PFHxA, PFHxS, PFOA and PFOS.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	45-48
34728202-0	2022	Spatial distributions of strontium isotope ratios in human hair and tap water from South Korea.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
34728202-3	2022	In this national-scale study conducted across South Korea, we investigated the spatial distribution patterns of 87Sr/86Sr ratios in human hair and tap water samples to determine their spatial variabilities and the relationships of isotopic signatures between hair and tap water.	Water	151-156	nuclear RNA export factor 1	Homo sapiens	147-150
34728202-3	2022	In this national-scale study conducted across South Korea, we investigated the spatial distribution patterns of 87Sr/86Sr ratios in human hair and tap water samples to determine their spatial variabilities and the relationships of isotopic signatures between hair and tap water.	Water	272-277	nuclear RNA export factor 1	Homo sapiens	268-271
34728202-4	2022	The strontium isoscapes of tap water and hair showed similar spatial distribution patterns.	Water	31-36	nuclear RNA export factor 1	Homo sapiens	27-30
34728202-6	2022	The 87Sr/86Sr ratios in human hair showed a significant and strong correlation with the ratios in tap water in eastern Korea, suggesting potential use of 87Sr/86Sr ratios in provenance studies.	Water	102-107	nuclear RNA export factor 1	Homo sapiens	98-101
34728202-7	2022	However, tap water and hair samples from western Korea did not show significant correlation between them, overall reducing the predictive power of the hair 87Sr/86Sr ratios for provenance studies.	Water	13-18	nuclear RNA export factor 1	Homo sapiens	9-12
34500280-7	2022	Furthermore, the DWTP and DWDS both prevented MPs from entering the tap water, thereby reducing their risk.	Water	72-77	nuclear RNA export factor 1	Homo sapiens	68-71
34871940-4	2022	Finally, the developed method was successfully used for determining dimethyl methylphosphonate in beverages such as coffee mix, fruit juice, tap water, milk, and tea.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
34388870-9	2022	The mechanisms of As mobilization/sorption at the solid-water interface can be affected by negatively charged DOM competing for sorption sites with As on Fe (oxy)(hydr)oxides and may be further modified by other anionic ubiquitous species such as phosphate, silicic acid, or sulfur.	Water	56-61	general transcription factor IIE subunit 1	Homo sapiens	154-156
34426130-7	2022	Column studies with CFH-12, GEH 101, and GWTR-Peat showed that the breakthrough started earlier with the mining ditch water compared to a synthetic vanadium solution (investigated only with CFH-12), whereas GEH 101 proved to have the best performance in column mode.	Water	118-123	complement factor H	Homo sapiens	20-23
34370193-0	2022	Pharmaceuticals in drinking water sources and tap water in a city in the middle reaches of the Yangtze River: occurrence, spatiotemporal distribution, and risk assessment.	Water	50-55	nuclear RNA export factor 1	Homo sapiens	46-49
34370193-4	2022	Only SMX and IBF were detected quantitatively with the highest concentrations of 0.69 ng/L and 1.28 ng/L in tap water, respectively.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
34370193-7	2022	The overall discrepancy of concentrations between drinking water sources and tap water might indicate the purification effect of drinking water treatment system.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
34370193-7	2022	The overall discrepancy of concentrations between drinking water sources and tap water might indicate the purification effect of drinking water treatment system.	Water	138-143	nuclear RNA export factor 1	Homo sapiens	77-80
34370193-11	2022	This study enriches environmental monitoring data of pharmaceuticals in drinking water sources and tap water, and provides scientific information for emerging pollutants management in drinking water system.	Water	103-108	nuclear RNA export factor 1	Homo sapiens	99-102
34350580-3	2022	Tap water, ethanol solutions, and sodium chloride at different concentrations were used as densification medium.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
34970801-8	2022	Distance of Tm3+ to terminal methyl carbons is a key determinant for sustaining BIRDS-temperature sensitivity without compromising CEST-pH contrast, however water solubility was influenced by introduction of hydrophobic methyl groups and hydrophilic carboxylate.	Water	157-162	tropomyosin 3	Homo sapiens	12-15
34889936-3	2021	PDI 3 showed the formation of a nanoring architecture in the self-assembled aggregated state (90% H2O-DMSO mixture) as observed by SEM and TEM studies.	Water	98-101	peptidyl arginine deiminase 3	Homo sapiens	0-5
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	epidermal patterning factor 1	Arabidopsis thaliana	711-715
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	Putative membrane lipoprotein	Arabidopsis thaliana	720-724
34727522-1	2021	Stomata are the pores in the epidermal surface of plant leaves that regulate the exchange of water and CO2 with the environment thus controlling leaf gas exchange.1 In the model dicot plant Arabidopsis thaliana, the transcription factors SPEECHLESS (SPCH) and MUTE sequentially control formative divisions in the stomatal lineage by forming heterodimers with ICE1.2 SPCH regulates entry into the stomatal lineage and its stability or activity is regulated by a mitogen-activated protein kinase (MAPK) signaling cascade, mediated by its interaction with ICE1.3-6 This MAPK pathway is regulated by extracellular epidermal patterning factor (EPFs) peptides, which bind a transmembrane receptor complex to inhibit (EPF1 and EPF2) or promote (STOMAGEN/EPFL9) stomatal development.7-9 MUTE controls the transition to guard mother cell identity and is regulated by the HD-ZIP transcription factor HDG2, which is expressed exclusively in stomatal lineage cells.10,11 Light signals acting through phytochrome and cryptochrome photoreceptors positively regulate stomatal development in response to increased irradiance.12,13 Here we report that stomatal development is also regulated by the redox state of the photosynthetic electron transport chain (PETC).	Water	93-98	death associated protein kinase 3	Homo sapiens	865-868
34817996-9	2021	The resonance frequency measurement of RLC circuits in combination with commercial plane coils showed that the capacitor worked in the megahertz band and that it collapsed when immersed in hot water.	Water	193-198	integrin subunit alpha 9	Homo sapiens	39-42
34530242-9	2021	The TaPL3 model calculated that PAHs are transported through water for a wider range of effects and a longer persistence, even up to 10 years.	Water	61-66	nuclear RNA export factor 3	Homo sapiens	4-9
34534832-0	2021	A pilot nationwide baseline survey on the concentrations of Neonicotinoid insecticides in tap water from China: Implication for human exposure.	Water	94-99	nuclear RNA export factor 1	Homo sapiens	90-93
34534832-2	2021	However, information on the NEO concentrations in tap water based on nationwide surveys is limited in China.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
34534832-3	2021	In this study, the levels of six NEOs were measured in tap water samples collected from 38 cities in China.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
34534832-4	2021	Across all sampling locations, the overall frequency of detection for at least one NEO was 100%, indicating that NEOs are ubiquitous in tap water from China.	Water	140-145	nuclear RNA export factor 1	Homo sapiens	136-139
34534832-6	2021	Significantly positive correlations (r = 0.655-0.902, p < 0.001) among all pairs of NEOs were observed, which showed that the sources of NEOs in tap water were common or related.	Water	149-154	nuclear RNA export factor 1	Homo sapiens	145-148
34534832-8	2021	Although the estimated daily intake of NEOs were much lower than the reference dose, the potential health risk of NEOs via tap water consumption should raise more public concern considering the high detection rates of NEOs in tap water.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
34534832-8	2021	Although the estimated daily intake of NEOs were much lower than the reference dose, the potential health risk of NEOs via tap water consumption should raise more public concern considering the high detection rates of NEOs in tap water.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	226-229
34798625-3	2021	In the process of ethanol-anhydrous (EA) and water splashing, the CPB@PAN fiber presents conspicuous blue and green emission when contacting with EA and water, and maintains intense blue and green FL for more than 4 months.	Water	45-50	carboxypeptidase B1	Homo sapiens	66-69
34798625-3	2021	In the process of ethanol-anhydrous (EA) and water splashing, the CPB@PAN fiber presents conspicuous blue and green emission when contacting with EA and water, and maintains intense blue and green FL for more than 4 months.	Water	153-158	carboxypeptidase B1	Homo sapiens	66-69
34860858-7	2021	The results showed that actG could negatively regulate the water-insoluble EPS synthesis and biofilm formation.	Water	59-64	actin, gamma 1	Rattus norvegicus	24-28
34862401-0	2021	Reducing the nanoparticles generated at the wheel-rail contact by applying tap water lubricant at subway train operational velocities.	Water	79-84	nuclear RNA export factor 1	Homo sapiens	75-78
34862401-1	2021	The formation characteristics and the reduction of nanoparticles emitted from wheel-rail contacts at subway-train velocities of 73, 90, and 113 km/h under dry and water-lubricated conditions (using tap water) were studied using a twin-disk rig.	Water	202-207	nuclear RNA export factor 1	Homo sapiens	198-201
34862401-6	2021	Adding water increased the NC of particles <= 35 nm in diameter, possibly owing to the increase in water vapor and mineral crystals from tap water.	Water	7-12	nuclear RNA export factor 1	Homo sapiens	137-140
34862401-6	2021	Adding water increased the NC of particles <= 35 nm in diameter, possibly owing to the increase in water vapor and mineral crystals from tap water.	Water	99-104	nuclear RNA export factor 1	Homo sapiens	137-140
34862401-6	2021	Adding water increased the NC of particles <= 35 nm in diameter, possibly owing to the increase in water vapor and mineral crystals from tap water.	Water	141-146	nuclear RNA export factor 1	Homo sapiens	137-140
34717965-9	2021	IGF-1 induced activation of YAP/TAZ, which resulted in improved cell viability in vitro, and reduced neurological deficits, brain water content, neuronal death and apoptosis, and cerebral infarct volume in vivo.	Water	130-135	tafazzin, phospholipid-lysophospholipid transacylase	Rattus norvegicus	32-35
34415660-1	2021	BACKGROUND: Aquaporin-4 (AQP4) water channel is involved in hippocampal plasticity and is the target of neuromyelitis optica spectrum disorders (NMOSD) autoimmunity.	Water	31-36	aquaporin 4	Homo sapiens	12-23
34415660-1	2021	BACKGROUND: Aquaporin-4 (AQP4) water channel is involved in hippocampal plasticity and is the target of neuromyelitis optica spectrum disorders (NMOSD) autoimmunity.	Water	31-36	aquaporin 4	Homo sapiens	25-29
34411946-5	2021	RESULTS: Participants without tap water were more likely to have depressive symptoms than participants with tap water (odds ratio (OR): 1.30; 95% confidence interval (CI): 1.19-1.42) (hazard ratio (HR): 1.18; 95% CI: 1.09-1.28).	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
34411946-6	2021	The lack of access to tap water in residence was positively related to the prevalence and incidence of symptoms of depression in almost all subgroups.	Water	26-31	nuclear RNA export factor 1	Homo sapiens	22-25
34411946-7	2021	Changing the water source from non-tap to tap water decreased the risk of depressive symptoms (HR: 0.69; 95% CI: 0.60 - 0.79).	Water	13-18	nuclear RNA export factor 1	Homo sapiens	35-38
34411946-7	2021	Changing the water source from non-tap to tap water decreased the risk of depressive symptoms (HR: 0.69; 95% CI: 0.60 - 0.79).	Water	13-18	nuclear RNA export factor 1	Homo sapiens	42-45
34411946-7	2021	Changing the water source from non-tap to tap water decreased the risk of depressive symptoms (HR: 0.69; 95% CI: 0.60 - 0.79).	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
34411946-10	2021	Therefore, providing tap water in residence may help prevent depression.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
34432604-5	2021	The risk distribution of the amount of bilge water that a ship can produce was determined with the data obtained by the Monte Carlo method for the first time in this study.	Water	45-50	inositol polyphosphate-5-phosphatase D	Homo sapiens	58-62
34432604-7	2021	It is found that the amount of bilge water that a ship can generate will vary in 0.78-3.16 m3, and this data can apply to every ship type.	Water	37-42	inositol polyphosphate-5-phosphatase D	Homo sapiens	50-54
34432604-7	2021	It is found that the amount of bilge water that a ship can generate will vary in 0.78-3.16 m3, and this data can apply to every ship type.	Water	37-42	inositol polyphosphate-5-phosphatase D	Homo sapiens	128-132
34757365-4	2021	In the case of off-targeting, when very few CeO2-GOx@CCM nanoparticles were accidentally delivered into normal tissue, its neutral pH environment (pH = 7.4) triggered a protective reaction, in which the H2O2 generated was catalyzed by CeO2 into non-toxic H2O and O2.	Water	255-258	hydroxyacid oxidase 1	Homo sapiens	49-52
34947816-0	2021	Comparing Native Crystal Structures and AlphaFold2 Predicted Water-Soluble G Protein-Coupled Receptor QTY Variants.	Water	61-66	atypical chemokine receptor 3	Homo sapiens	75-101
34532998-6	2021	C 6 -TRZ-TFP COF displayed excellent HER activity in the electrochemical water-splitting with a very low overpotential of 200 mV and specific activity of 0.2831 mA/cm 2 together with high retention in the catalytic activity after a longer duration of electrocatalysis of the aqueous solution of 0.5M H 2 SO 4 .	Water	73-78	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	9-12
34797551-2	2022	A specific antigenic target, astrocytic water channel aquaporin-4 (AQP4) has already been identified, and it can be recognized explicitly by the autoantibody marker NMO-IgG.	Water	40-45	aquaporin 4	Homo sapiens	67-71
34748346-2	2021	To elucidate the role of adsorbed water in spin diffusion and proton conductivity, PMETAC was degassed under vacuum.	Water	34-39	spindlin 1	Homo sapiens	43-47
34734698-3	2021	Owing to the excellent moisture sensitivity of CNF and GO, the hydrophobic CNT favoring rapid desorption of water molecules, and the unique porous structure with numerous nanochannels for accelerating the water exchange rate, this CNF/GO/CNT composite film delivers excellent actuation including an ultrafast response/recovery (0.8/2 s), large deformation, and sufficient cycle stability (no detectable degradation after 1000 cycles) in response to ambient gradient humidity.	Water	108-113	NPHS1 adhesion molecule, nephrin	Homo sapiens	231-234
34734698-3	2021	Owing to the excellent moisture sensitivity of CNF and GO, the hydrophobic CNT favoring rapid desorption of water molecules, and the unique porous structure with numerous nanochannels for accelerating the water exchange rate, this CNF/GO/CNT composite film delivers excellent actuation including an ultrafast response/recovery (0.8/2 s), large deformation, and sufficient cycle stability (no detectable degradation after 1000 cycles) in response to ambient gradient humidity.	Water	205-210	NPHS1 adhesion molecule, nephrin	Homo sapiens	231-234
34789317-3	2021	However, it takes time to dissolve CO2 in tap water and because the dissolved CO2 concentration decreases over time, the actual CO2 concentration is likely lower than the stated target concentration.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
34789317-6	2021	Participants were first immersed for 15 min in a tap water bath at 40  C to raise body temperature.	Water	53-58	nuclear RNA export factor 1	Homo sapiens	49-52
34789317-10	2021	RESULTS: Immersion in 40  C tap water caused Tac to rise 0.64 +- 0.25  C in the tap water session and 0.62 +- 0.27  C in the CO2-enriched water session (P > 0.05).	Water	32-37	nuclear RNA export factor 1	Homo sapiens	28-31
34364114-8	2021	These are, in order of importance, selectivity of the ion-selective membrane to main ion followed by the membrane resistance to parallel processes, such as water ingress to the ISM, light sensitivity, change in temperature, presence of gasses in solution and pH and finally resistance of the ion-selective membrane to fouling.	Water	156-161	isthmin 1	Homo sapiens	177-180
34247071-3	2021	We estimated the health and environmental impacts of four drinking water scenarios for the Barcelona population: 1) currently observed drinking water sources; a complete shift to 2) tap water; 3) bottled water; or 4) filtered tap water.	Water	186-191	nuclear RNA export factor 1	Homo sapiens	182-185
34247071-3	2021	We estimated the health and environmental impacts of four drinking water scenarios for the Barcelona population: 1) currently observed drinking water sources; a complete shift to 2) tap water; 3) bottled water; or 4) filtered tap water.	Water	230-235	nuclear RNA export factor 1	Homo sapiens	226-229
34247071-6	2021	The scenario where the entire population consumed tap water yielded the lowest environmental impact on ecosystems and resources, while the scenario where the entire population drank bottled water yielded the highest impacts (1400 and 3500 times higher for species lost and resource use, respectively).	Water	54-59	nuclear RNA export factor 1	Homo sapiens	50-53
34247071-7	2021	Meeting drinking water needs using bottled or filtered tap water led to the lowest bladder cancer DALYs (respectively, 140 and 9 times lower than using tap water) in the Barcelona population.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
34247071-7	2021	Meeting drinking water needs using bottled or filtered tap water led to the lowest bladder cancer DALYs (respectively, 140 and 9 times lower than using tap water) in the Barcelona population.	Water	156-161	nuclear RNA export factor 1	Homo sapiens	152-155
34785232-7	2022	Combinedly, our work reveals that metformin byproducts have been disseminated to urban water cycle and contaminated tap water, increasing potential toxic risk for drinking water.	Water	120-125	nuclear RNA export factor 1	Homo sapiens	116-119
34785232-7	2022	Combinedly, our work reveals that metformin byproducts have been disseminated to urban water cycle and contaminated tap water, increasing potential toxic risk for drinking water.	Water	172-177	nuclear RNA export factor 1	Homo sapiens	116-119
34696590-4	2021	Herein, we describe a novel approach using fungal melanin for developing melanized-cationic cellulose nanofiber (melanized-C-CNF) foams that can successfully remove pollutants in water systems.	Water	179-184	NPHS1 adhesion molecule, nephrin	Homo sapiens	125-128
34748962-6	2022	Using high-throughput optimization and a series of evaluations, a stable water-dispersible 150-200nm nano-encapsulated drug (named P-4) conjugated with hepatic targeting moiety was synthesized and characterized (named P-21).	Water	73-78	KRAS proto-oncogene, GTPase	Rattus norvegicus	218-222
34694793-6	2021	The detection limits in deionized water and tap water were determined to be 1.07 and 0.75 ppb, respectively, which are lower than the US Environmental Protection Agency standard of the maximum contamination of uranium in drinking water.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
34694793-6	2021	The detection limits in deionized water and tap water were determined to be 1.07 and 0.75 ppb, respectively, which are lower than the US Environmental Protection Agency standard of the maximum contamination of uranium in drinking water.	Water	230-235	nuclear RNA export factor 1	Homo sapiens	44-47
34698322-12	2021	Among these product channels, (8OH-9MG + HN7) + has the most favorable formation probability, especially in the presence of additional water molecules.	Water	135-140	MT-RNR2 like 7 (pseudogene)	Homo sapiens	41-44
34555359-8	2021	The free energy calculations using the replica-exchange umbrella sampling simulations present an energy cost of 4.3 kcal/mol at the membrane surface for the membrane insertion of pTB from bulk water.	Water	193-198	polypyrimidine tract binding protein 1	Homo sapiens	179-182
34728716-6	2021	Furthermore, (DEMEMA)(FSI) inhibits the growth of sulfate-reducing bacteria SRB in saline water.	Water	90-95	chaperonin containing TCP1 subunit 4	Homo sapiens	76-79
34553436-4	2021	It is hypothesized that such water channels can facilitate cross-membrane transport, with important consequences including lysosomal membrane permeabilization, an emerging mechanism of cellular toxicity that involves the release of cathepsin B and generation of radical oxygen species leading to cell apoptosis.	Water	29-34	cathepsin B	Homo sapiens	232-243
34173901-6	2021	RA presence, methotrexate use, higher rheumatoid factor titer, higher NGAL, older age and higher BMI should be considered independent risk factors for greater left ventricular myocardium water content.	Water	187-192	lipocalin 2	Homo sapiens	70-74
34284015-2	2021	In this study, the leaching of PTEs including both heavy metals and metalloids (metal(loid)s) from CBs into deionized water (DW), tap water (TW), and seawater (SW) was checked during the different contact times (from 60 min to 60 days).	Water	134-139	nuclear RNA export factor 1	Homo sapiens	130-133
34606658-2	2021	AtBBX21 overexpressing (BBX21-OE) potato (Solanum tuberosum) plants, cultivated in optimal water conditions, have higher photosynthesis rate and stomatal conductance without penalty in water use efficiency (WUE) and with a higher tuber yield.	Water	185-190	salt tolerance homolog2	Arabidopsis thaliana	0-7
34850710-2	2021	In this regard, the goal of this research was to evaluate the overall physicochemical, phycological, and bacteriological properties of tap water samples taken periodically from 12 different Tanta city schools.	Water	139-144	nuclear RNA export factor 1	Homo sapiens	135-138
34850716-5	2021	In this study we evaluated households" hourly time-of-use behaviour in response to the Cape Town drought at two prominent inflection points identified by previous studies: the announcement of the Critical Water Shortages Disaster Plan in October 2017 and the introduction of Level 6B restrictions in February 2018.	Water	205-210	structural maintenance of chromosomes 2	Homo sapiens	87-91
34850732-4	2021	In order to improve the accuracy and safety of UAV offshore operations, this study designed an electric propulsion unmanned ship and its automatic control system according to the requirements of water quality sampling.	Water	195-200	inositol polyphosphate-5-phosphatase D	Homo sapiens	124-128
34850732-9	2021	The unmanned ship constructed in this study can be used as an auxiliary tool for water quality detection.	Water	81-86	inositol polyphosphate-5-phosphatase D	Homo sapiens	13-17
34949329-6	2021	When spiked concentration was 1.0 mug/L for pure water and tap water, the recoveries were 81%-106% and 75%-117%, respectively, and relative standard deviations were both less than 4%.	Water	63-68	nuclear RNA export factor 1	Homo sapiens	59-62
34949329-7	2021	When spiked concentration was 12 mug/L for pure water and tap water, the recoveries were 92%-101% and 86%-106%, respectively, and relative standard deviations were less than 4% and 2%, respectively.	Water	62-67	nuclear RNA export factor 1	Homo sapiens	58-61
34771029-9	2021	After using the system, the oxidability of water decreased from 6.26 mg O2 dm-3 to 0.4 mg O2 dm-3.	Water	43-48	immunoglobulin kappa variable 1D-39	Homo sapiens	72-79
34771029-9	2021	After using the system, the oxidability of water decreased from 6.26 mg O2 dm-3 to 0.4 mg O2 dm-3.	Water	43-48	immunoglobulin kappa variable 1D-39	Homo sapiens	90-97
34718426-1	2022	Neuromyelitis optica is an autoimmune inflammatory disorder targeting aquaporin-4 water channels in CNS astrocytes.	Water	82-87	aquaporin 4	Homo sapiens	70-81
34769944-0	2021	Influence of a Survival Swimming Training Programme on Water Safety Knowledge, Attitudes and Skills: A Randomized Controlled Trial among Young Adults in Sri Lanka.	Water	55-60	sorcin	Homo sapiens	153-156
34769944-3	2021	This study aimed to evaluate the effectiveness of an adapted educational intervention, "Swim for Safety" on improving water safety knowledge, attitudes and survival swimming skills among undergraduates (19-28 years) in Sri Lanka.	Water	118-123	sorcin	Homo sapiens	219-222
34925779-1	2021	Cyanidin-3-O-glucoside (C3G) is a kind of water-soluble pigment widely existing in many plants.	Water	42-47	Rap guanine nucleotide exchange factor 1	Homo sapiens	24-27
34714870-0	2021	Assessing tap water awareness: The development of an empirically-based framework.	Water	14-19	nuclear RNA export factor 1	Homo sapiens	10-13
34714870-3	2021	To address this gap, we conceptualise, operationalise and assess tap water awareness, hereby differentiating between cognitive awareness (head), affectional awareness (heart), and behavioural awareness (hands).	Water	69-74	nuclear RNA export factor 1	Homo sapiens	65-68
34714870-4	2021	In parallel, we also differentiate between tap water quality, quantity and system.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
34714870-7	2021	Based on the analysis of the results of the first empirical application of our tap water awareness assessment framework, we conclude that-with a score 53.5 points out of 100-tap water awareness in the Netherlands shows ample room for improvement.	Water	178-183	nuclear RNA export factor 1	Homo sapiens	174-177
34453833-7	2021	We exposed adult female mice to IAA in drinking water in vivo and found 0.5 and 10 mg/L IAA concentrations lead to significantly increased mRNA levels of kisspeptin (Kiss1) in the arcuate nucleus, while not affecting Kiss1 in the anteroventral periventricular nucleus.	Water	48-53	KiSS-1 metastasis-suppressor	Mus musculus	154-164
34453833-7	2021	We exposed adult female mice to IAA in drinking water in vivo and found 0.5 and 10 mg/L IAA concentrations lead to significantly increased mRNA levels of kisspeptin (Kiss1) in the arcuate nucleus, while not affecting Kiss1 in the anteroventral periventricular nucleus.	Water	48-53	KiSS-1 metastasis-suppressor	Mus musculus	166-171
34590101-4	2021	The Gef-PY NCs have good water-solubility, non-toxicity (correspond to 1/10 dosage of effective gefitinib (hydrochloride) (Gef HCl) (normal drug administration and slow-release) and high stability (120 days, 80% drug retention at 4 or 25  C).	Water	25-30	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	4-7
34590101-8	2021	Such excellent properties (e.g., water-solubility, non-toxicity, high stability, kidney targeting and long retention) of Gef-PY NCs create their prominent anti-fibrosis capabilities, such as decreasing approximately 40% tubulointerstitial fibrosis area and 68% expression of collagen I within 7 days.	Water	33-38	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	121-124
34669129-3	2022	Under the reclaimed water irrigation, the content of soil total salinity, chloride ions, and water soluble sodium in soil of most plants was averagely 160.3%, 83.3%, and 67.5% higher than that of tap water, respectively.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	196-199
34669129-3	2022	Under the reclaimed water irrigation, the content of soil total salinity, chloride ions, and water soluble sodium in soil of most plants was averagely 160.3%, 83.3%, and 67.5% higher than that of tap water, respectively.	Water	200-205	nuclear RNA export factor 1	Homo sapiens	196-199
34669129-6	2022	Compared with the tap water irrigation, the content of alkaline nitrogen in 5 plants increased (averagely 25.8%) after 5-year irrigation with reclaimed water.	Water	22-27	nuclear RNA export factor 1	Homo sapiens	18-21
34614460-4	2021	The heterotrophic plate counts with R2A media were high (> 100 CFU/mL) in some SWSS tank and tap water samples.	Water	97-102	nuclear RNA export factor 1	Homo sapiens	93-96
34614460-5	2021	Propidium monoazide (PMA)-qPCR revealed a one magnitude higher abundance of viable bacteria in the tank and tap water samples (average 103.63+-1.10 and 103.65+-1.25 gene copies/mL, respectively) compared with the input water samples, and Enterococcus, Acanthamoeba, and Hartmannella vermiformis were only detected in the tanks.	Water	112-117	nuclear RNA export factor 1	Homo sapiens	108-111
34614460-6	2021	In particular, the high detection frequency of Legionella in 35% tank and 21% tap water samples suggested it is a supplementary microbial safety indicator in SWSSs.	Water	82-87	nuclear RNA export factor 1	Homo sapiens	78-81
34720900-0	2021	Evaluation of the Activity of Choline Acetyltransferase From Different Synaptosomal Fractions at the Distinct Stages of Spatial Learning in the Morris Water Maze.	Water	151-156	choline O-acetyltransferase	Rattus norvegicus	30-55
34720900-2	2021	The aim of this study was to evaluate the association of the activity of membrane-bound and soluble choline acetyltransferase (ChAT) in the synaptosomal sub-fractions of the neocortex and hippocampus with performance of the spatial navigation task in the Morris water maze at different temporal stages of memory trace formation.	Water	262-267	choline O-acetyltransferase	Rattus norvegicus	100-125
34720900-2	2021	The aim of this study was to evaluate the association of the activity of membrane-bound and soluble choline acetyltransferase (ChAT) in the synaptosomal sub-fractions of the neocortex and hippocampus with performance of the spatial navigation task in the Morris water maze at different temporal stages of memory trace formation.	Water	262-267	choline O-acetyltransferase	Rattus norvegicus	127-131
34139853-6	2021	The difference between the daily volume of water consumed by the patients who received gum thickeners (928.33 (331.27) mL) and those who received starch thickeners (670.00 (288.35) mL) was statistically significant (p = 0.012).	Water	43-48	thrombopoietin	Mus musculus	119-121
34139853-6	2021	The difference between the daily volume of water consumed by the patients who received gum thickeners (928.33 (331.27) mL) and those who received starch thickeners (670.00 (288.35) mL) was statistically significant (p = 0.012).	Water	43-48	thrombopoietin	Mus musculus	181-183
34641788-0	2021	From digestion and absorption to innate immunity and health care: water and food intake may contribute to IL-22 in ILC3-dependent mucosal immunity in the jejunum.	Water	66-71	interleukin 22	Homo sapiens	106-111
34641788-1	2021	In this review, with our current studies we demonstrated medical evidence that water and food intake are useful for IL-22-related mucosal immunity-dependent maintenance of health care.	Water	79-84	interleukin 22	Homo sapiens	116-121
34641788-5	2021	IL-22 released from the ILC3 is transported through mesenteric lymph in collaboration with the albumin-mediated movement of consumed water.	Water	133-138	interleukin 22	Homo sapiens	0-5
34641788-6	2021	Thus, water intake-mediated upregulation of IL-22-dependent mucosal immunity contributes to the traditional Japanese health care practices.	Water	6-11	interleukin 22	Homo sapiens	44-49
34546269-0	2021	A facile approach to prepare silica hybrid, spin-crossover water-soluble nanoparticles as potential candidates for thermally responsive MRI agents.	Water	59-64	spindlin 1	Homo sapiens	44-48
34546269-1	2021	A reverse micelle method was used for the synthesis of water-soluble silica hybrid, spin-crossover (SCO) nanoparticles (NPs).	Water	55-60	spindlin 1	Homo sapiens	84-88
34137009-2	2021	Using high-throughput quantitative PCR, we analyzed the prevalence and diversity of ARGs and mobile genetic elements (MGEs) in water supplies.	Water	127-132	serpin family A member 2 (gene/pseudogene)	Homo sapiens	84-88
34137009-4	2021	Absolute abundance and detected number of ARGs decreased significantly (P < 0.05) in sand filter water after drinking water treatment and increased thereafter at point-of-use (household tap water).	Water	97-102	serpin family A member 2 (gene/pseudogene)	Homo sapiens	42-46
34137009-4	2021	Absolute abundance and detected number of ARGs decreased significantly (P < 0.05) in sand filter water after drinking water treatment and increased thereafter at point-of-use (household tap water).	Water	118-123	serpin family A member 2 (gene/pseudogene)	Homo sapiens	42-46
34137009-4	2021	Absolute abundance and detected number of ARGs decreased significantly (P < 0.05) in sand filter water after drinking water treatment and increased thereafter at point-of-use (household tap water).	Water	190-195	serpin family A member 2 (gene/pseudogene)	Homo sapiens	42-46
34137009-8	2021	This study suggested that although the absolute abundance of ARGs decreased after treatment of drinking water treatment plants (DWTPs), the rebounded of ARGs in the water distribution system should not be neglected.	Water	104-109	serpin family A member 2 (gene/pseudogene)	Homo sapiens	61-65
34137009-8	2021	This study suggested that although the absolute abundance of ARGs decreased after treatment of drinking water treatment plants (DWTPs), the rebounded of ARGs in the water distribution system should not be neglected.	Water	165-170	serpin family A member 2 (gene/pseudogene)	Homo sapiens	61-65
34137009-8	2021	This study suggested that although the absolute abundance of ARGs decreased after treatment of drinking water treatment plants (DWTPs), the rebounded of ARGs in the water distribution system should not be neglected.	Water	165-170	serpin family A member 2 (gene/pseudogene)	Homo sapiens	153-157
34403678-5	2021	The emerged V2O5@Ch/Cu-TMA is regarded as an excellent nanobiosorbent for removal of inorganic contaminant as Cr(VI) from all natural water samples (tap, sea and wastewater) with percentages range 92.43%-96.95% and organic contaminant as LEVO drug from tap and wastewater (91.99%-97.20%).	Water	134-139	nuclear RNA export factor 1	Homo sapiens	149-152
34242954-0	2021	Seawater contamination associated with in-water cleaning of ship hulls and the potential risk to the marine environment.	Water	42-47	inositol polyphosphate-5-phosphatase D	Homo sapiens	60-64
34242954-1	2021	In-water cleaning can clear-off foulants from ship hulls to prevent transportation of non-indigenous species and reduce hull friction and consequent fuel use.	Water	3-8	inositol polyphosphate-5-phosphatase D	Homo sapiens	46-50
34213495-4	2021	The participants drank 500 mL of purified tap water or AEW every day for 2 weeks.	Water	46-51	nuclear RNA export factor 1	Homo sapiens	42-45
34390190-3	2021	Herein, an ultralow Ru incorporated amorphous cobalt-based oxide (Ru-CoOx /NF), effectively driving the electrolysis of water at high current densities in alkaline water and seawater, is designed and constructed.	Water	120-125	neurofascin	Homo sapiens	75-77
34390190-3	2021	Herein, an ultralow Ru incorporated amorphous cobalt-based oxide (Ru-CoOx /NF), effectively driving the electrolysis of water at high current densities in alkaline water and seawater, is designed and constructed.	Water	164-169	neurofascin	Homo sapiens	75-77
34390190-6	2021	Then the electrolyzer apparatus assembled with Ru-CoOx /NF, just requires the ultra-low voltage of 2.2 and 2.62 V to support the current density of 1000 mA cm-2 in alkaline water and seawater electrolysis, respectively, for hydrogen production, better than that of the commercial Pt/C and RuO2 catalysts.	Water	173-178	neurofascin	Homo sapiens	56-58
34390190-7	2021	This work demonstrates that Ru-CoOx /NF is one of the most promising catalysts for industrial applications and provides a possibility for exploration of high-current-density water electrocatalysis by changing the crystallinity of the catalyst.	Water	174-179	neurofascin	Homo sapiens	37-39
34581980-5	2021	MiR-149-5p overexpression effectively reduced MCAO/R-induced infarct volume, neurological score, and brain water content as well as OGD/R-induced cortical neurons apoptosis and OGD/R-induced expression of TNF-alpha, IL-4, IL-6, IL-1beta, and COX-2.	Water	107-112	microRNA 149	Rattus norvegicus	0-7
34582491-1	2021	This study, based in San Bernardino County, Southern California, collected and examined tap water samples within the area to explore the feasibility of adopting non-industrial equipment and methods to reduce water hardness and total dissolved solids(TDS).	Water	92-97	nuclear RNA export factor 1	Homo sapiens	88-91
34582491-7	2021	When added to room temperature tap water, there is a continuous increase in TDS of 24.8% at the 30 mg/L mark.	Water	35-40	nuclear RNA export factor 1	Homo sapiens	31-34
34582491-11	2021	The reduction of these solids will help lower water hardness and improve the taste of tap water.	Water	90-95	nuclear RNA export factor 1	Homo sapiens	86-89
34582491-12	2021	These results will help direct residents to drink more tap water rather than bottled water with similar taste and health benefits for a cheaper price as well as a reduction on plastic usage.	Water	59-64	nuclear RNA export factor 1	Homo sapiens	55-58
34548087-9	2021	GSMTx4 was used to inhibit Piezo1, which alleviated VILI-induced pathologic changes, water content and protein leakage in the lungs, and the induction of systemic inflammatory mediators, and improved the 7-day mortality rate in the model rats.	Water	85-90	piezo-type mechanosensitive ion channel component 1	Rattus norvegicus	27-33
34521353-8	2021	Depleted SOX2 or PVT1 alleviated brain injury in MCAO rats as reflected by neuronal apoptosis and oxidative stress restriction, brain water content reduction, and neurological deficit and neuron survival improvements.	Water	134-139	Pvt1 oncogene	Rattus norvegicus	17-21
34760235-2	2021	The comparative effects of acidic electrolyzed water (ACEW) and tap water (TW) on the triglyceride configuration, typical lipid concomitants, and antioxidant properties of flaxseed were conducted during 0-5 days of germination.	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
34270995-3	2021	The NS3 enzyme requires a peptide cofactor, called NS4A, with its central part interacting with the NS3 beta-sheet and flexible, protruding terminal tails that are unstructured in water solution.	Water	180-185	KRAS proto-oncogene, GTPase	Homo sapiens	4-7
34286717-8	2021	This method was evaluated and validated using synthetic water samples, following the current standard DIN EN ISO 9562:2004 for the determination of the sum parameter adsorbable organic halides (AOX) for water quality.	Water	203-208	acyl-CoA oxidase 1	Homo sapiens	194-197
34120199-4	2021	The prevalence in open well and tap water was recorded 33% and 20%, respectively.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
34462369-2	2021	Aquaporin-4 (AQP4), the main water channel in the brain plays a key role in water homeostasis and edema formation in the central nervous system.	Water	29-34	aquaporin 4	Homo sapiens	0-11
34462369-2	2021	Aquaporin-4 (AQP4), the main water channel in the brain plays a key role in water homeostasis and edema formation in the central nervous system.	Water	29-34	aquaporin 4	Homo sapiens	13-17
34462369-2	2021	Aquaporin-4 (AQP4), the main water channel in the brain plays a key role in water homeostasis and edema formation in the central nervous system.	Water	76-81	aquaporin 4	Homo sapiens	0-11
34462369-2	2021	Aquaporin-4 (AQP4), the main water channel in the brain plays a key role in water homeostasis and edema formation in the central nervous system.	Water	76-81	aquaporin 4	Homo sapiens	13-17
34646466-8	2021	We also found a relationship between prealternate molt and generalist and water habitats for Western Palearctic species.	Water	74-79	transmembrane protein 132D	Homo sapiens	50-54
34175710-6	2021	Meanwhile, PM2.5, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1).	Water	32-37	heme oxygenase 1	Rattus norvegicus	282-298
34175710-6	2021	Meanwhile, PM2.5, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1).	Water	32-37	heme oxygenase 1	Rattus norvegicus	300-304
34483144-3	2021	EAU was induced via immunization with the interphotoreceptor retinoid-binding protein (IRBP) and oral administration of either a vehicle or betaine (100 mg/kg) for 9 consecutive days.	Water	0-3	retinol binding protein 3	Rattus norvegicus	42-85
34483144-3	2021	EAU was induced via immunization with the interphotoreceptor retinoid-binding protein (IRBP) and oral administration of either a vehicle or betaine (100 mg/kg) for 9 consecutive days.	Water	0-3	retinol binding protein 3	Rattus norvegicus	87-91
34512271-6	2021	Our results indicated that alcohol exposure (either 5% or 10% in drinking water) for 3 weeks remarkably reduced mGFP + /NG2- new myelin and mGFP + /CC1 + new oligodendrocytes in the prefrontal cortex and corpus callosum of 6-month-old NG2-CreERt; mT/mG mice as compared to controls without changing the mGFP + /NG2 + oligodendrocyte precursor cells (OPCs) density, suggesting that alcohol exposure may inhibit oligodendrocyte differentiation.	Water	74-79	chondroitin sulfate proteoglycan 4	Mus musculus	120-123
34227731-0	2021	Amorphous Fe(OH)3 Passivating CeO2 Nanorods: A Noble-Metal-Free Photocatalyst for Water Oxidation.	Water	82-87	general transcription factor IIE subunit 1	Homo sapiens	10-17
34227731-2	2021	Here, we design a CeO2 nanorods composite loading amorphous Fe(OH)3 cocatalyst, and the composites are prepared via a secondary water bath in 100  C. The as-synthesized CeO2/amorphous Fe(OH)3 composites exhibit superior light photocatalytic activities than pure CeO2, especially the sample with a loading time of 60 min.	Water	128-133	general transcription factor IIE subunit 1	Homo sapiens	184-191
34227731-6	2021	Thirdly, the maximum interface with intimate contact between CeO2 and amorphous Fe(OH)3 cocatalyst accelerates the photogenerated charge separation efficiency and thus improves the photocatalytic performance of CeO2 in photocatalytic water oxidation.	Water	234-239	general transcription factor IIE subunit 1	Homo sapiens	80-87
34259506-0	2021	Spectrally Resolved Estimation of Water Entropy in the Active Site of Human Carbonic Anhydrase II.	Water	34-39	carbonic anhydrase 2	Homo sapiens	76-97
34259506-3	2021	One example is human carbonic anhydrase II, whose active site harbors a conserved network of structural water molecules that are essential for enzymatic catalysis.	Water	104-109	carbonic anhydrase 2	Homo sapiens	21-42
34259506-5	2021	Here, we use atomistic molecular dynamics simulations to compute the absolute entropy of the individual water molecules confined in the active site of hCAII using a spectrally resolved estimation (SRE) approach.	Water	104-109	carbonic anhydrase 2	Homo sapiens	151-156
34439809-8	2021	Taken together, we conclude that a high soil water content induced non-PCD by decreasing HCAR activity when whole plants were incubated in darkness to induce senescence; thus, the investigation of the fundamental aspects of biochemistry and the regulation of leaf senescence are affected by using dark-induced leaf senescence.	Water	45-50	coenzyme F420 hydrogenase family / dehydrogenase, beta subunit family	Arabidopsis thaliana	89-93
34121459-5	2021	Predictors of fH were explored using generalized least-squares regression, including water temperature, discharge, fish size and fish origin (wild versus hatchery).	Water	85-90	fumarate hydratase, mitochondrial	Oncorhynchus tshawytscha	14-16
33714350-9	2021	In addition, the water contact angle of the coating with added CNF increased to 145.0 , which was 46% higher than that without the CNFs.	Water	17-22	NPHS1 adhesion molecule, nephrin	Homo sapiens	63-66
34077824-8	2021	RESULTS: After overexpressing miR-18a, the expression levels of RUNX1, Occludin and ZO-1 were decreased, but the Evan"s blue contents and brain water contents were significantly increased in ICH rats.	Water	144-149	microRNA 18a	Rattus norvegicus	30-37
34107416-1	2021	BACKGROUND: Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) technique used to quantify cerebral blood perfusion by labeling blood water as it flows throughout the brain.	Water	149-154	spindlin 1	Homo sapiens	21-25
34367056-3	2021	Objective: To examine the pathogenicity of autoantibodies targeting the astrocyte water channel aquaporin-4 (aquaporin-4 (AQP4)-immunoglobulin G (AQP4-IgG)) in the optic nerve.	Water	82-87	aquaporin 4	Mus musculus	109-120
34367056-3	2021	Objective: To examine the pathogenicity of autoantibodies targeting the astrocyte water channel aquaporin-4 (aquaporin-4 (AQP4)-immunoglobulin G (AQP4-IgG)) in the optic nerve.	Water	82-87	aquaporin 4	Mus musculus	122-126
34367056-3	2021	Objective: To examine the pathogenicity of autoantibodies targeting the astrocyte water channel aquaporin-4 (aquaporin-4 (AQP4)-immunoglobulin G (AQP4-IgG)) in the optic nerve.	Water	82-87	aquaporin 4	Mus musculus	146-150
34091221-0	2021	Roles and Knowledge Gaps of Point-of-Use Technologies for Mitigating Health Risks from Disinfection Byproducts in Tap Water: A Critical Review.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	114-117
34299138-6	2021	By immunizing IL-27Ralpha-/- mice and their wild-type (WT) littermates for EAU, we demonstrated that IL-27 signaling deficiency exacerbated EAU with severe ocular inflammation and impairment of visual function.	Water	75-78	interleukin 27	Mus musculus	101-106
34299138-6	2021	By immunizing IL-27Ralpha-/- mice and their wild-type (WT) littermates for EAU, we demonstrated that IL-27 signaling deficiency exacerbated EAU with severe ocular inflammation and impairment of visual function.	Water	140-143	interleukin 27	Mus musculus	101-106
34299138-12	2021	These results identified that IL-27 signaling plays a suppressive role in EAU by regulating multiple CD4+ cell subsets, including the effector Th1 and Th17 cells and the regulatory Tr1 cells.	Water	74-77	interleukin 27	Mus musculus	30-35
34299138-12	2021	These results identified that IL-27 signaling plays a suppressive role in EAU by regulating multiple CD4+ cell subsets, including the effector Th1 and Th17 cells and the regulatory Tr1 cells.	Water	74-77	CD4 antigen	Mus musculus	101-104
34251181-2	2021	It is formed from its precursor tropoelastin, a 60-72 kDa water-soluble and temperature-responsive protein that coacervates at physiological temperature, undergoing a phenomenon termed lower critical solution temperature (LCST).	Water	58-63	elastin	Homo sapiens	32-44
34359195-0	2021	Thermal Comfort Index for Lactating Water Buffaloes under Hot and Humid Climate.	Water	36-41	alcohol dehydrogenase iron containing 1	Homo sapiens	58-61
34298865-0	2021	The Receptor-Like Kinase ERECTA Confers Improved Water Use Efficiency and Drought Tolerance to Poplar via Modulating Stomatal Density.	Water	49-54	receptor-like kinase	None	4-24
34219583-5	2022	The expression of the astrocytic water channel AQP4 and astrocyte activation were evaluated with immunofluorescence.	Water	33-38	aquaporin 4	Mus musculus	47-51
34511458-1	2021	The purpose of the study is to estimate the effectiveness of complex treatment of patients with pulmonary tuberculosis in the phase of resorption and carnification at the spa stage with the use of drinking mineral water of medium mineralization and focused pulse magnetic therapy in combination with antituberculous chemotherapy.	Water	214-219	surfactant protein A2	Homo sapiens	171-174
34193268-12	2021	Compared with diabetic mice, FTVII-modified BMSCs significantly promoted the gastrointestinal motility and the ENS remodeling, including intestinal peristalsis (P < 0.05), increased feces excretion (P < 0.05) and the water content of the feces (P < 0.05), restored the spontaneous contraction of the colon (P < 0.05), and upregulated the protein expression levels of PGP9.5 (P < 0.01), GFAP (P < 0.001), and GDNF (P < 0.05), while unmodified BMSCs did not (P > 0.05).	Water	217-222	fucosyltransferase 7	Mus musculus	29-34
34188143-1	2021	We conducted a comprehensive overall tap water hardness assessment for Japan.	Water	41-46	nuclear RNA export factor 1	Homo sapiens	37-40
34188143-2	2021	Tap water was collected from 665 points throughout Japan, and its standing position was quantitatively clarified by prefecture.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
34188143-3	2021	The mean and median hardness of tap water in Japan was 48.9 +- 25.8 (1sigma SD) and 46.0 mg/L, respectively.	Water	36-41	nuclear RNA export factor 1	Homo sapiens	32-35
34188143-6	2021	The impact of the distribution system"s water pipes on tap water hardness is discussed using a unified index to evaluate variations in hardness from raw to tap water.	Water	40-45	nuclear RNA export factor 1	Homo sapiens	55-58
34188143-6	2021	The impact of the distribution system"s water pipes on tap water hardness is discussed using a unified index to evaluate variations in hardness from raw to tap water.	Water	160-165	nuclear RNA export factor 1	Homo sapiens	55-58
34188143-6	2021	The impact of the distribution system"s water pipes on tap water hardness is discussed using a unified index to evaluate variations in hardness from raw to tap water.	Water	160-165	nuclear RNA export factor 1	Homo sapiens	156-159
34188143-7	2021	A comparison of the variations in hardness showed that hardness variations from raw to purified water and from purified to tap water exhibited a 20% variation range.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
34188143-8	2021	Furthermore, tap water hardness and its fluctuations in any region of Japan were found to be caused by raw water hardness.	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
34262475-12	2021	The blood levels of cortisol, CK, and LDH were also elevated after hot water immersion.	Water	71-76	cytidine/uridine monophosphate kinase 1	Homo sapiens	30-32
34214381-16	2021	CONCLUSIONS: Administering chondroitin sulfate in a dose of 7 mg in 2 mL distilled water for 2 and 4 weeks may increase production of TGF-beta, the osteoblast numbers and the callus compressive strength in fracture healing.	Water	83-88	transforming growth factor alpha	Rattus norvegicus	134-142
34129341-0	2021	Slowdown of Water Dynamics from the Top to the Bottom of the GroEL Cavity.	Water	12-17	heat shock protein family D (Hsp60) member 1	Homo sapiens	61-66
34129341-3	2021	Herein, we report measurements of water dynamics in the equatorial and apical domains of the GroEL cavity in the apo and football states, using site-specific tryptophanyl mutagenesis as an intrinsic optical probe with femtosecond resolution combined with molecular dynamics simulations.	Water	34-39	heat shock protein family D (Hsp60) member 1	Homo sapiens	93-98
34129341-5	2021	The results suggest that the GroEL cavity provides a unique water environment that may facilitate substrate protein folding.	Water	60-65	heat shock protein family D (Hsp60) member 1	Homo sapiens	29-34
34220465-10	2021	Additionally, a single corticotropin releasing factor receptor 1 antagonist treatment significantly decreased both water and ethanol intake in socially- and individually-housed mice up to 3 h post-treatment, though the effect on water intake was longer lasting.	Water	115-120	corticotropin releasing hormone receptor 1	Mus musculus	23-64
34220465-10	2021	Additionally, a single corticotropin releasing factor receptor 1 antagonist treatment significantly decreased both water and ethanol intake in socially- and individually-housed mice up to 3 h post-treatment, though the effect on water intake was longer lasting.	Water	229-234	corticotropin releasing hormone receptor 1	Mus musculus	23-64
34085828-1	2021	The solvent effect of the TaO2+ reaction with water molecules in the gas phase is examined.	Water	46-51	TAO kinase 2	Homo sapiens	26-30
34085828-2	2021	Stoichiometric TaO2(H2O)n+ cations are generated by the laser vaporization of a tantalum metal target in the pulsed supersonic expansion of H2O/He mixed gas.	Water	20-23	TAO kinase 2	Homo sapiens	15-19
34085828-2	2021	Stoichiometric TaO2(H2O)n+ cations are generated by the laser vaporization of a tantalum metal target in the pulsed supersonic expansion of H2O/He mixed gas.	Water	140-143	TAO kinase 2	Homo sapiens	15-19
34085828-3	2021	The infrared photodissociation spectra of TaO2(H2O)n+ cations are measured using the argon-tagging technology in the 2800-3850 cm-1 region.	Water	47-50	TAO kinase 2	Homo sapiens	42-46
34085828-5	2021	In the TaO2+ reaction with one H2O molecule, both the hydrated adduct H2O-TaO2+ and dihydroxide TaO(OH)2+ are generated.	Water	31-34	TAO kinase 2	Homo sapiens	7-11
34131143-0	2021	Spin pinning effect to reconstructed oxyhydroxide layer on ferromagnetic oxides for enhanced water oxidation.	Water	93-98	spindlin 1	Homo sapiens	0-4
34100164-2	2021	This study investigated the presence and the quantity of microplastics in bottled and tap water from five regions in Saudi Arabia and estimated the dietary intake of microplastics.	Water	90-95	nuclear RNA export factor 1	Homo sapiens	86-89
34106055-7	2021	Redistribution of the water channel protein, AQP4, reflected by change from normal punctate labelling to intense diffuse staining in hippocampal sclerosis samples, indicated an altered glia-vascular interface, disrupting blood-brain barrier permeability.	Water	22-27	aquaporin 4	Homo sapiens	45-49
34485979-3	2021	Despite being waterborne, the PIL in bulk is intrinsically insoluble in water and the formed coating is stable in water.	Water	114-119	serpin family A member 2 (gene/pseudogene)	Homo sapiens	30-33
34194514-5	2021	Results: Physicochemical qualities of the water samples from tap water sources were found to be pH (6.88 +- 0.05), turbidity (5.15 +- 0.006 NTU), electrical conductivity (170.6 +- 0.1 muS/cm), residual chlorine (0.19 +- 0.003 mg/L), and fluoride (1.17 +- 0.009 mg/L).	Water	42-47	nuclear RNA export factor 1	Homo sapiens	61-64
34194514-5	2021	Results: Physicochemical qualities of the water samples from tap water sources were found to be pH (6.88 +- 0.05), turbidity (5.15 +- 0.006 NTU), electrical conductivity (170.6 +- 0.1 muS/cm), residual chlorine (0.19 +- 0.003 mg/L), and fluoride (1.17 +- 0.009 mg/L).	Water	65-70	nuclear RNA export factor 1	Homo sapiens	61-64
34194514-7	2021	Removal efficiency of the treatment plant for total coliforms up to 91.6% (15 +- 0.26 CFU/100 mL in tap water) and faecal coliforms up to 99% (1.51 +- 0.03 CFU/100 mL in tap water) was recorded.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	100-103
34194514-7	2021	Removal efficiency of the treatment plant for total coliforms up to 91.6% (15 +- 0.26 CFU/100 mL in tap water) and faecal coliforms up to 99% (1.51 +- 0.03 CFU/100 mL in tap water) was recorded.	Water	174-179	nuclear RNA export factor 1	Homo sapiens	170-173
34194514-8	2021	Parameters of pH, temperature, and faecal coliform were statistically significant different at p < 0.05 in tap water source.	Water	111-116	nuclear RNA export factor 1	Homo sapiens	107-110
34071256-8	2021	The fluoride content in tap water samples collected from public sources averaged from 0.35 to 1.11 ppm.	Water	28-33	nuclear RNA export factor 1	Homo sapiens	24-27
34163836-1	2021	In this report it is shown that nitroacetic acid 1 (O2NCH2CO2H) can be conveniently used to control the pH of a water solution over time.	Water	112-117	mediator complex subunit 25	Homo sapiens	44-50
34259433-8	2021	tap water (control group).	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
34278925-0	2021	The effects of endurance exercise combined with high-temperature head-out water immersion on serum concentration of brain-derived neurotrophic factor in healthy young men.	Water	74-79	brain derived neurotrophic factor	Homo sapiens	116-149
34278925-1	2021	OBJECTIVES: To evaluate acute changes in serum brain-derived neurotrophic factor (BDNF) concentration following combined endurance exercise and heat stress through head-out water immersion (HOI).	Water	173-178	brain derived neurotrophic factor	Homo sapiens	47-80
34278925-1	2021	OBJECTIVES: To evaluate acute changes in serum brain-derived neurotrophic factor (BDNF) concentration following combined endurance exercise and heat stress through head-out water immersion (HOI).	Water	173-178	brain derived neurotrophic factor	Homo sapiens	82-86
34792000-10	2021	Ang-(1-7) attenuated the increased urinary flow and the fractional excretion of H2O and potassium observed in GM rats but intensified the elevated excretion of sodium in these animals.	Water	80-83	angiogenin	Rattus norvegicus	0-8
35525019-5	2022	Low field nuclear magnetic resonance showed that T21 and T22 of SF3 sample were shorter than SF1 and SF2 samples (P < 0.05), implying that SF3 reduced the mobility of mobile water and free water.	Water	174-179	serine and arginine rich splicing factor 1	Homo sapiens	101-104
35525019-5	2022	Low field nuclear magnetic resonance showed that T21 and T22 of SF3 sample were shorter than SF1 and SF2 samples (P < 0.05), implying that SF3 reduced the mobility of mobile water and free water.	Water	189-194	serine and arginine rich splicing factor 1	Homo sapiens	101-104
35567878-8	2022	Remarkably, the Fe(OH)3@PDA@WPU was capable of separating various oil/water mixtures even under some severe conditions (e.g. erosion in a saturated sodium chloride solution and longtime sonication), demonstrating high potential in marine oily sewage treatment.	Water	70-75	general transcription factor IIE subunit 1	Homo sapiens	16-23
35334135-1	2022	Employing pure water, the ultimate green source of hydrogen donor to initiate chemical reactions that involve a hydrogen atom transfer (HAT) step is fascinating but challenging due to its large H-O bond dissociation energy (BDE H-O = 5.1 eV).	Water	15-20	homeobox D13	Homo sapiens	224-227
35593200-0	2022	Spin state engineering of spinel oxides by integration of Cr doping and a p-n junction for water oxidation.	Water	91-96	spindlin 1	Homo sapiens	0-4
35609007-2	2022	The reaction with (Ni(H2O)6)Cl2 and PdCl2 produced ionic metal(II) complexes (kappa3-P,P",P""((5-Ph2P-Ace-6-)2P(OH))MCl)Cl, which upon addition of Et3N gave rise to zwitterionic metal(II) complexes kappa3-P,P",P""((5-Ph2P-Ace-6-)2P(O))MCl (M = Ni, Pd).	Water	22-25	phosducin like 2	Homo sapiens	36-41
35081754-10	2022	RESULTS: Overall, 36% of adults reported using a filter for drinking tap water at home; 14% did not drink tap water at home.	Water	73-78	nuclear RNA export factor 1	Homo sapiens	69-72
35081754-13	2022	Using a water filter was associated with higher odds of drinking >3 cups/day of tap water (AOR=1.33, 95%CI=1.13-1.56) and lower odds of SSBs >=1 time/day (AOR=0.76, 95%CI=0.62-0.92).	Water	8-13	nuclear RNA export factor 1	Homo sapiens	80-83
35081754-13	2022	Using a water filter was associated with higher odds of drinking >3 cups/day of tap water (AOR=1.33, 95%CI=1.13-1.56) and lower odds of SSBs >=1 time/day (AOR=0.76, 95%CI=0.62-0.92).	Water	84-89	nuclear RNA export factor 1	Homo sapiens	80-83
35081754-14	2022	Not drinking tap water at home was associated with higher odds of drinking >3 cups/day bottled water (AOR=3.46, 95%CI=2.70-4.44).	Water	17-22	nuclear RNA export factor 1	Homo sapiens	13-16
35081754-14	2022	Not drinking tap water at home was associated with higher odds of drinking >3 cups/day bottled water (AOR=3.46, 95%CI=2.70-4.44).	Water	95-100	nuclear RNA export factor 1	Homo sapiens	13-16
35081754-15	2022	CONCLUSIONS: WFU was associated with higher tap water intake and lower SSB intake among U.S. adults.	Water	48-53	nuclear RNA export factor 1	Homo sapiens	44-47
35561596-1	2022	Recent research findings have confirmed the presence of illicit drugs in tap water from some European Union (UE) member states.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
35561596-2	2022	Contaminants in tap water come directly from drinking water sources such as rivers or lakes owing to inefficient removal at wastewater treatment and water purification plants.	Water	20-25	nuclear RNA export factor 1	Homo sapiens	16-19
35561596-2	2022	Contaminants in tap water come directly from drinking water sources such as rivers or lakes owing to inefficient removal at wastewater treatment and water purification plants.	Water	54-59	nuclear RNA export factor 1	Homo sapiens	16-19
35561596-2	2022	Contaminants in tap water come directly from drinking water sources such as rivers or lakes owing to inefficient removal at wastewater treatment and water purification plants.	Water	149-154	nuclear RNA export factor 1	Homo sapiens	16-19
35561596-3	2022	This work was aimed at setting a starting point for assessing the health risks of exposure to twelve drugs of abuse through consumption of tap water in the European population.	Water	143-148	nuclear RNA export factor 1	Homo sapiens	139-142
35561596-4	2022	For this purpose, a method using supramolecular solvents (SUPRAS) was developed to extract drugs in the opioid, amphetamine, cocaine and cannabinoid groups from tap water for their determination by liquid chromatography-tandem mass spectrometry (LC-MS/MS).	Water	165-170	nuclear RNA export factor 1	Homo sapiens	161-164
35561596-5	2022	A total of 119 tap water samples were collected from eight EU countries for analysis.	Water	19-24	nuclear RNA export factor 1	Homo sapiens	15-18
35561596-7	2022	The mean exposure to the drugs through consumption of tap water was calculated to be 0.0064-3.531 ng/kg day for adults and 0.0247-6.7580 ng/kg day for children, whereas that resulting from dermal contact was estimated to be 4-7 orders of magnitude lower.	Water	58-63	nuclear RNA export factor 1	Homo sapiens	54-57
35098472-10	2022	Barreled water drinking was associated with a 30.4% (95% CI: 11.8%, 52.0%) increase in bis(1-chloro-2-propyl) 1-hydroxy-2-propyl phosphate (BCIPHIPP) compared to tap water drinking.	Water	9-14	nuclear RNA export factor 1	Homo sapiens	162-165
35098472-10	2022	Barreled water drinking was associated with a 30.4% (95% CI: 11.8%, 52.0%) increase in bis(1-chloro-2-propyl) 1-hydroxy-2-propyl phosphate (BCIPHIPP) compared to tap water drinking.	Water	166-171	nuclear RNA export factor 1	Homo sapiens	162-165
35569778-4	2022	In a model of LPS-induced inflammation, we found that hypoxia induced by infusing nitrogen into water increased the expression of pro-inflammatory cytokines, such as il-1beta, il-6, and il-8.	Water	96-101	chemokine (C-X-C motif) ligand 8a	Danio rerio	186-190
35150953-4	2022	Moreover, the integrated water splitting device assembled by Mo,Fe-NiCoPx/NF as both anode and cathode only needs a voltage of 1.545 V to reach 10 mA cm-2.	Water	25-30	neurofascin	Homo sapiens	74-76
35582984-1	2022	We characterized the anti-E2, syn-E2, inv-SN2, and ret-SN2 reaction channels for the reaction of microsolvated HO-(H2O)n anions with CH3CH2X (X = Cl, Br, I), using the CCSD(T)/PP/t//MP2/ECP/d level method, to understand how a solvent influences the competing E2 and SN2 reactions.	Water	115-118	synemin	Homo sapiens	30-33
35616204-10	2022	Hence, it is important to establish a method for the determination of THMs in ship ballast water.	Water	91-96	inositol polyphosphate-5-phosphatase D	Homo sapiens	78-82
35616204-12	2022	At present, ship ballast water is mostly analyzed by gas chromatography (GC) using an electron capture detector (ECD) or by gas chromatography-mass spectrometry (GC-MS).	Water	25-30	inositol polyphosphate-5-phosphatase D	Homo sapiens	12-16
35616204-29	2022	The proposed method is accurate, stable, and reliable, and it can be used for monitoring the four THMs in ship ballast water.	Water	119-124	inositol polyphosphate-5-phosphatase D	Homo sapiens	106-110
35616204-30	2022	The method was applied for the detection of 36 ship ballast water samples.	Water	60-65	inositol polyphosphate-5-phosphatase D	Homo sapiens	47-51
35616204-33	2022	Based on the analysis of several ship ballast water samples (electrolytic water), it was concluded that the greater the number of bromine atoms in the THMs, the higher are the detection rate and detection value in ship ballast water.	Water	227-232	inositol polyphosphate-5-phosphatase D	Homo sapiens	214-218
35616204-35	2022	China has acceded to the International Convention on Ship Ballast Water and Sediment Control and Management.	Water	66-71	inositol polyphosphate-5-phosphatase D	Homo sapiens	53-57
35616204-36	2022	There is an urgent need to establish analysis methods with high sensitivity, good stability, and high accuracy in addition to determining standards and regulations for ship ballast water.	Water	181-186	inositol polyphosphate-5-phosphatase D	Homo sapiens	168-172
35596582-1	2022	OBJECTIVE: Astrocytes outline the perivascular space (PVS) and regulate fluids exchange through the aquaporin-4 water channel.	Water	112-117	aquaporin 4	Homo sapiens	100-111
35590444-3	2022	Herein, we design a hierarchical nanowire array of metal sulfides heterostructure on nickel foam (FeCoNiS x /NF) as a novel type of hybrid electrocatalyst for overall water splitting.	Water	167-172	neurofascin	Homo sapiens	109-111
35590444-6	2022	Moreover, the FeCoNiS x /NF-based water electrolyzer exhibits a small potential of 1.57 V for a high current density of 50 mA cm -2 .	Water	34-39	neurofascin	Homo sapiens	25-27
35615428-12	2022	Caspase-3 and MDA levels increased in the CuO NP and CuSO4 0.5 (H2O) groups compared with the control group, and there was a significant difference between the two concentrations used.	Water	64-67	caspase 3	Mus musculus	0-9
35567666-9	2022	Bio-decolorization at high dye concentrations, promising decolorization rate, and non-toxic nature of treated products suggest the potential of strain RA1 for bioremediation of dye-contaminated water and its re-use in the industries.	Water	194-199	RA1	Homo sapiens	151-154
35074388-1	2022	Around 90% of the energy requirement for urban water systems management is for heating domestic tap water.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	96-99
35074388-1	2022	Around 90% of the energy requirement for urban water systems management is for heating domestic tap water.	Water	100-105	nuclear RNA export factor 1	Homo sapiens	96-99
35537674-8	2022	CONCLUSION: On average, students had negative school water security experiences, which decreased their consumption of water from tap water sources.	Water	118-123	nuclear RNA export factor 1	Homo sapiens	129-132
35537674-8	2022	CONCLUSION: On average, students had negative school water security experiences, which decreased their consumption of water from tap water sources.	Water	133-138	nuclear RNA export factor 1	Homo sapiens	129-132
35511329-5	2022	Although the NP concentrations measured in the drinking water sources of urban areas were significantly higher than those in rural areas (P < 0.05), the tap water and urine NP concentrations measured in urban areas were unexpectedly lower than those of rural areas (P < 0.05).	Water	157-162	nuclear RNA export factor 1	Homo sapiens	153-156
35102375-1	2022	BACKGROUND: In the US, problems with the provision of safe, affordable water have resulted in an increasing number of adults who avoid their tap water, which may indicate underlying water insecurity.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	141-144
35102375-1	2022	BACKGROUND: In the US, problems with the provision of safe, affordable water have resulted in an increasing number of adults who avoid their tap water, which may indicate underlying water insecurity.	Water	145-150	nuclear RNA export factor 1	Homo sapiens	141-144
35102375-1	2022	BACKGROUND: In the US, problems with the provision of safe, affordable water have resulted in an increasing number of adults who avoid their tap water, which may indicate underlying water insecurity.	Water	182-187	nuclear RNA export factor 1	Homo sapiens	141-144
35102375-3	2022	OBJECTIVES: This article aims to demonstrate how water intake variables from dietary recall data relate to and predict a key water insecurity proxy, i.e., tap water avoidance.	Water	49-54	nuclear RNA export factor 1	Homo sapiens	155-158
35102375-3	2022	OBJECTIVES: This article aims to demonstrate how water intake variables from dietary recall data relate to and predict a key water insecurity proxy, i.e., tap water avoidance.	Water	125-130	nuclear RNA export factor 1	Homo sapiens	155-158
35102375-3	2022	OBJECTIVES: This article aims to demonstrate how water intake variables from dietary recall data relate to and predict a key water insecurity proxy, i.e., tap water avoidance.	Water	159-164	nuclear RNA export factor 1	Homo sapiens	155-158
35102375-5	2022	Second, I use multiple linear and logistic regressions to test how tap water avoidance relates to plain water intake and sugar-sweetened beverage consumption.	Water	71-76	nuclear RNA export factor 1	Homo sapiens	67-70
35102375-5	2022	Second, I use multiple linear and logistic regressions to test how tap water avoidance relates to plain water intake and sugar-sweetened beverage consumption.	Water	104-109	nuclear RNA export factor 1	Homo sapiens	67-70
35420409-1	2022	We report an electrolysis system using NiFe layered double hydroxide/CoMoO4/nickel foam (NFLDH/CMO/NF) as the anode and CMO/NF as the cathode for simultaneous phenol electro-oxidation and water electrolysis.	Water	188-193	neurofascin	Homo sapiens	99-101
35420409-1	2022	We report an electrolysis system using NiFe layered double hydroxide/CoMoO4/nickel foam (NFLDH/CMO/NF) as the anode and CMO/NF as the cathode for simultaneous phenol electro-oxidation and water electrolysis.	Water	188-193	neurofascin	Homo sapiens	124-126
35505126-2	2022	The fabricated NixSy@MnOxHy/NF shows outstanding bifunctional activity and stability for hydrogen evolution reaction and oxygen evolution reaction, as well as overall-water-splitting performance.	Water	167-172	neurofascin	Homo sapiens	28-30
35505126-10	2022	Therefore, NixSy@MnOxHy/NF exhibits exceptional bifunctional activity and stability for overall water splitting, with low overpotentials of 326 and 356 mV for OER at 100 and 500 mA cm-2, respectively, along with high stability of 150 h at 100 mA cm-2.	Water	96-101	neurofascin	Homo sapiens	24-26
35436087-0	2022	An Adaptable Water-Soluble Molecular Boat for Selective Separation of Phenanthrene from Isomeric Anthracene.	Water	13-18	ataxin 1 like	Homo sapiens	37-41
35436087-3	2022	We report here a water-soluble Pd(II) molecular boat (MB1) with unusual structural topology that was obtained by assembling a flexible tetrapyridyl donor (L) with a cis-Pd(II) acceptor.	Water	17-22	ataxin 1 like	Homo sapiens	48-52
35473943-3	2022	Glymphatic clearance, or perivascular CSF-interstitial fluid exchange, is dependent on the astroglial water channel aquaporin-4 (AQP4) as deletion of Aqp4 in mice slows perivascular exchange, impairs Abeta clearance, and promotes Abeta plaque formation.	Water	102-107	aquaporin 4	Mus musculus	129-133
35473943-3	2022	Glymphatic clearance, or perivascular CSF-interstitial fluid exchange, is dependent on the astroglial water channel aquaporin-4 (AQP4) as deletion of Aqp4 in mice slows perivascular exchange, impairs Abeta clearance, and promotes Abeta plaque formation.	Water	102-107	aquaporin 4	Mus musculus	150-154
35518345-12	2022	After treatment, GOL administration ameliorated EP and increased the expression of mucoprotein -5AC (MUC5AC), and GOL promoted water secretion of the respiratory tract by increasing the expression of aquaporin-5 (AQP5) and decreasing the levels of proinflammatory cytokines (TNF-alpha, IL-6, and IL-1beta).	Water	127-132	aquaporin 5	Rattus norvegicus	213-217
35500389-10	2022	(iii) Cell2, especially with ACN/H2O mobile phases, is the CSP that allows baseline enantioresolution for a higher number of compounds.	Water	33-36	carboxyl ester lipase pseudogene	Homo sapiens	6-11
35500389-12	2022	(v) Cell3 is the only CSP that provides marked complementary enantioselectivity to that of Cell2, almost orthogonal in MeOH/H2O mobile phases.	Water	124-127	carboxyl ester lipase pseudogene	Homo sapiens	91-96
35451117-9	2022	With increasing volume of infused water (1000-2000 mL), the median cecal insertion time increased gradually from 11.4 minutes to 23.0 minutes; P < 0.001).	Water	34-39	thrombopoietin	Mus musculus	51-53
35514996-4	2022	A combination of oral AHCC  and dual immune checkpoint blockade (DICB), including PD-1/CTLA-4 blockade, had reduced tumor growth and increased granzyme B and Ki-67 expression by tumor-infiltrating CD8+ T cells in MC38 colon cancer bearing mice compared to a combination of water and DICB.	Water	273-278	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	87-93
35514996-4	2022	A combination of oral AHCC  and dual immune checkpoint blockade (DICB), including PD-1/CTLA-4 blockade, had reduced tumor growth and increased granzyme B and Ki-67 expression by tumor-infiltrating CD8+ T cells in MC38 colon cancer bearing mice compared to a combination of water and DICB.	Water	273-278	antigen identified by monoclonal antibody Ki 67	Mus musculus	158-163
35278425-1	2022	Yfh1 is a yeast protein with the peculiar characteristic to undergo, in the absence of salt, cold denaturation at temperatures above the water freezing point.	Water	137-142	ferroxidase	Saccharomyces cerevisiae S288C	0-4
35344356-0	2022	Point-of-Use Filters for Lead Removal from Tap Water: Opportunities and Challenges.	Water	47-52	nuclear RNA export factor 1	Homo sapiens	43-46
35440593-2	2022	Mapping where wells tap fossil aquifers is relevant for water quality and quantity management.	Water	56-61	nuclear RNA export factor 1	Homo sapiens	20-23
35220763-7	2022	Our predictions suggest that if the mean sea-level were to increase by 1 m in the Batticaloa region (Sri Lanka), this would cause landward communities to be inundated with brackish water at various depths.	Water	181-186	sorcin	Homo sapiens	101-104
35454180-1	2022	Since the discovery of a specific autoantibody in patients with neuromyelitis optica spectrum disorder (NMOSD) in 2004, the water channel aquaporin-4 (AQP4) has attracted attention as a target of autoimmune diseases of the central nervous system.	Water	124-129	aquaporin 4	Homo sapiens	151-155
35404404-4	2022	Detached leaves from aha2-6 single mutant Arabidopsis thaliana plants lost as much water as bak1-4 single and aha2-6 bak1-4 double mutants, with all three mutants losing more water than the wild type (Col-0).	Water	83-88	H[+]-ATPase 2	Arabidopsis thaliana	21-25
35411658-5	2022	In the current study, we aimed to evaluate in the CeA of female rats whether chronic water avoidance stress (WAS) alters DNA methylation of the GR exon 17 promoter region, a region homologous to the human GR promoter.	Water	85-90	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	144-146
35180453-8	2022	In exposure treatments where Sr was highly elevated and water Ca was reduced, the hepatic gene expression of Ca signaling receptors beta-2 adrenergic receptor (Adrb2) and inositol-1,4,5-triphosphate receptor-2 (Itpr2) were inhibited, highlighting novel potential pathways of Sr toxicity in rainbow trout.	Water	56-61	beta-2 adrenergic receptor	Oncorhynchus mykiss	132-158
35180453-8	2022	In exposure treatments where Sr was highly elevated and water Ca was reduced, the hepatic gene expression of Ca signaling receptors beta-2 adrenergic receptor (Adrb2) and inositol-1,4,5-triphosphate receptor-2 (Itpr2) were inhibited, highlighting novel potential pathways of Sr toxicity in rainbow trout.	Water	56-61	beta-2 adrenergic receptor	Oncorhynchus mykiss	160-165
35378122-1	2022	Recently, halides (silver halides, AgX; perosvkite halides, ABX3) and oxyhalides (bismuth oxyhalides, BiOX) based nanomaterials are noticeable photocatalysts in the degradation of organic water pollutants.	Water	188-193	UDP-N-acetylglucosamine pyrophosphorylase 1	Homo sapiens	35-38
35355372-0	2022	Tap water as a natural vehicle for microorganisms shaping the human gut microbiome.	Water	4-9	nuclear RNA export factor 1	Homo sapiens	0-3
35355372-3	2022	In the current study, an exhaustive shotgun metagenomics analysis of the tap water microbiome highlighted the occurrence of a highly genetic biodiversity of the microbial communities residing in fresh water and the existence of a conserved core tap water microbiota largely represented by novel microbial species, representing microbial dark matter.	Water	77-82	nuclear RNA export factor 1	Homo sapiens	73-76
35355372-3	2022	In the current study, an exhaustive shotgun metagenomics analysis of the tap water microbiome highlighted the occurrence of a highly genetic biodiversity of the microbial communities residing in fresh water and the existence of a conserved core tap water microbiota largely represented by novel microbial species, representing microbial dark matter.	Water	201-206	nuclear RNA export factor 1	Homo sapiens	73-76
35355372-3	2022	In the current study, an exhaustive shotgun metagenomics analysis of the tap water microbiome highlighted the occurrence of a highly genetic biodiversity of the microbial communities residing in fresh water and the existence of a conserved core tap water microbiota largely represented by novel microbial species, representing microbial dark matter.	Water	249-254	nuclear RNA export factor 1	Homo sapiens	73-76
35355372-3	2022	In the current study, an exhaustive shotgun metagenomics analysis of the tap water microbiome highlighted the occurrence of a highly genetic biodiversity of the microbial communities residing in fresh water and the existence of a conserved core tap water microbiota largely represented by novel microbial species, representing microbial dark matter.	Water	249-254	nuclear RNA export factor 1	Homo sapiens	245-248
35355372-5	2022	Accordingly, investigation of the fecal microbiota content of a subject that daily consumed tap water for three years provides proof for horizontal transmission and colonization of water bacteria in the human gut.	Water	96-101	nuclear RNA export factor 1	Homo sapiens	92-95
35355372-5	2022	Accordingly, investigation of the fecal microbiota content of a subject that daily consumed tap water for three years provides proof for horizontal transmission and colonization of water bacteria in the human gut.	Water	181-186	nuclear RNA export factor 1	Homo sapiens	92-95
35434460-1	2022	A simulation-based bias analysis of haloacetic acids in tap water and hypospadias.	Water	60-65	nuclear RNA export factor 1	Homo sapiens	56-59
35434460-5	2022	In this bias analysis, we used a uniform distribution to randomly select 11%-14% of employed women that were assumed to change municipal water systems between home and work and imputed new contaminant exposures for tap water beverages consumed at work among the selected women using resampled values from the control population.	Water	219-224	nuclear RNA export factor 1	Homo sapiens	215-218
35346946-12	2022	CONCLUSIONS: Succinic acid could worsen EAU induced by IRBP in mice.	Water	40-43	retinol binding protein 3, interstitial	Mus musculus	55-59
35466232-4	2022	The results showed that family education, education expectation, books, education participation, social communication, and tap water had a positive impact on both the Chinese and math cognitive ability of children, while children"s age, gender, and family size had a negative impact on cognitive ability, and the impact of genes was attenuated by family capital.	Water	127-132	nuclear RNA export factor 1	Homo sapiens	123-126
35392081-9	2022	By contrast, soluble C3, C3(H2O), and the C3 fragments C3b, iC3b and C3d bound to CCPs 8-9 of FHR5.	Water	28-31	complement factor H related 5	Homo sapiens	94-98
35411221-0	2022	Antibiotic heliomycin and its water-soluble 4-aminomethylated derivative provoke cell death in T24 bladder cancer cells by targeting sirtuin 1 (SIRT1).	Water	30-35	sirtuin 1	Homo sapiens	133-142
35411221-0	2022	Antibiotic heliomycin and its water-soluble 4-aminomethylated derivative provoke cell death in T24 bladder cancer cells by targeting sirtuin 1 (SIRT1).	Water	30-35	sirtuin 1	Homo sapiens	144-149
35411221-10	2022	Taken together, these findings clearly show that SIRT1 is targeted and downregulated by heliomycin and its water-soluble 4-aminomethylated derivative (HD2) possibly through autophagic and/or proteasomal degradation, leading to cell death and growth suppression of T24 bladder cancer cells.	Water	107-112	sirtuin 1	Homo sapiens	49-54
35168727-3	2022	The developed flexible sensor affords rapid, accurate and stable response for the Ni (II) ions monitoring at its trace level in the biological fluids including human saliva and sweat samples in addition to tap water as an environmental sample without any preconditioning steps over pH range of 2-8 with detection limit of 2.7 x 10-6.	Water	210-215	nuclear RNA export factor 1	Homo sapiens	206-209
34982500-4	2022	In addition, by using the real pool water, PtL + -SeV 2+ achieved multiple functions, including H 2 production, antibacterial action and acid removal, which supplied a new strategy to solve various problems in real life via a single system.	Water	36-41	pancreatic lipase	Homo sapiens	43-46
35253486-8	2022	In the early stage of the disease, radiating and water-soaking lesions appeared between the main veins and side veins of Pmt leaves.	Water	49-54	putrescine N-methyltransferase	Solanum lycopersicum	121-124
35253486-24	2022	Radiating and water-soaked lesions with yellow haloes were observed between the main veins and side veins of Pmt leaves 5 days after inoculation and were similar to those caused by R. andropogonis in the field.	Water	14-19	putrescine N-methyltransferase	Solanum lycopersicum	109-112
34990747-8	2022	In parallel, hippocampal-dependent spatial learning and memory processes were affected by IL-10 overproduction as assessed by the Morris water maze test.	Water	137-142	interleukin 10	Homo sapiens	90-95
35364941-0	2022	Short-time least squares spectral analysis of pass-by noise in water from a rigid inflatable boat.	Water	63-68	ataxin 1 like	Homo sapiens	93-97
35364941-7	2022	The developed short-time least squares spectral analysis is illustrated on noise radiated from a rigid inflatable boat in shallow water.	Water	130-135	ataxin 1 like	Homo sapiens	114-118
35350003-1	2022	This study aimed to assess the heavy metal (HM) profile of the main upland tributaries of three major rivers, the Mahaweli, the Deduru and the Gin Rivers, which are commonly used for urban water supply in Sri Lanka.	Water	189-194	sorcin	Homo sapiens	205-208
35171587-0	2022	High-Field Magnetoelectric and Spin-Phonon Coupling in Multiferroic (NH4)2(FeCl5 (H2O)).	Water	82-85	spindlin 1	Homo sapiens	31-35
35129351-1	2022	Here, we report the magnetic field-induced self-assembly of a conjugated block copolymer, poly(3-hexylthiopene)-block-poly(ethylene glycol) (P3HT-b-PEG), and iron oxide nanoparticles (IONPs) at the air-water interface.	Water	202-207	striated muscle enriched protein kinase	Homo sapiens	146-151
35206375-3	2022	In addition, the daily exposure and cumulative health risk of susceptible populations due to drinking tap water were evaluated by using four different reference dose (RfDs) sources.	Water	106-111	nuclear RNA export factor 1	Homo sapiens	102-105
35206375-4	2022	The maximum concentrations of PAEs in raw water were between 1.68 and 4.84 and 0.52 and 1.24 microg/L in tap water.	Water	109-114	nuclear RNA export factor 1	Homo sapiens	105-108
35206375-5	2022	Moreover, the levels of PAEs in the tap water samples indicated the poor PAEs removal efficiency of the conventional treatment process (59.9-69.1%).	Water	40-45	nuclear RNA export factor 1	Homo sapiens	36-39
35206375-11	2022	However, we recommend a future cumulative risk assessment of vulnerable groups considering their simultaneous exposure to all chemicals that have antiandrogenic effects via tap water.	Water	177-182	nuclear RNA export factor 1	Homo sapiens	173-176
35157081-11	2022	In conclusion, size-symmetric competition for water (beta1   1) may only be assumed when size is quantified as basal area or sapwood area, and when describing a general pattern across forest types and species.	Water	46-51	immunoglobulin kappa variable 3D-20	Homo sapiens	53-62
35157264-1	2022	BACKGROUND: Studies investigating the effects of cold-water immersion (CWI) on the recovery of athletic performance, perceptual measures and creatine kinase (CK) have reported mixed results in physically active populations.	Water	54-59	cytidine/uridine monophosphate kinase 1	Homo sapiens	141-156
35157264-1	2022	BACKGROUND: Studies investigating the effects of cold-water immersion (CWI) on the recovery of athletic performance, perceptual measures and creatine kinase (CK) have reported mixed results in physically active populations.	Water	54-59	cytidine/uridine monophosphate kinase 1	Homo sapiens	158-160
35119812-5	2022	The h-NP products with grafting densities of 0.6-2.1 nm-2 can be well dispersed in water at room temperature.	Water	83-88	kallikrein related peptidase 8	Homo sapiens	4-8
35259861-0	2022	(The Safety of Bladder Irrigation with Solution G Prepared with Tap Water).	Water	68-73	nuclear RNA export factor 1	Homo sapiens	64-67
35164237-2	2022	The aim of this study was to evaluate the influence of water and wastewater treatment on reducing the concentrations of zinc (Zn), nickel (Ni), iron (Fe), manganese (Mn), copper (Cu), lead (Pb), and arsenic (As) in the Western Pomerania Voivodeship in Poland.	Water	55-60	general transcription factor IIE subunit 1	Homo sapiens	150-152
35105914-8	2022	Our system, based on the paramagnetic behavior that deoxyhemoglobin or methemoglobin containing RBCs experience when suspended in water after applying a magnetic field, uses a combination of magnets and microfluidics and has the ability to track the movement of thousands of red cells in a short period of time.	Water	130-135	hemoglobin subunit gamma 2	Homo sapiens	71-84
35207090-5	2022	The results showed that the CNF/HNTs nanoparticle system modified by two silane coupling agents enhanced the tensile strength (TS) of the starch-PVA composite membranes by increments of 60.11% and 68.35%, and, in addition, the water resistance of starch-PVA composite membrane improved.	Water	227-232	NPHS1 adhesion molecule, nephrin	Homo sapiens	28-31
35126617-8	2022	The levels of cTnI and HS cTnI in the experimental group increased with the extension of time and the deepening of poisoning degree; four hours after admission, ST2 and NT proBNP water in the control group and the experimental group increased significantly on average.	Water	179-184	troponin I3, cardiac type	Homo sapiens	14-18
35057680-1	2022	Salvianolic acid A (SA-A), a water-soluble compound extracted from traditional Chinese herb Radix Salvia miltiorrhiza, has anti-fibrotic effects on carbon tetrachloride (CCl4)-induced liver fibrosis.	Water	29-34	serum amyloid A cluster	Mus musculus	20-24
34982023-11	2022	CONCLUSION: There is a broad range in the minerals found in tap water between the different production sites in the nine distribution regions in Flanders.	Water	64-69	nuclear RNA export factor 1	Homo sapiens	60-63
35055730-0	2022	Returning Individual Tap Water Testing Results to Research Study Participants after a Wildfire Disaster.	Water	25-30	nuclear RNA export factor 1	Homo sapiens	21-24
35056831-6	2022	This work demonstrates an effective strategy to realize a fluorescent sensor NFM that has a fast and sensitive response to pH, which will benefit its application of pH sensor monitoring in the water treatment process.	Water	193-198	neurofilament medium chain	Homo sapiens	77-80
34995313-6	2022	We validate the groundwater isoscape against an independent data set of tap water values and show that the model accurately predicts tap water values in communities known to use groundwater resources.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	72-75
34995313-6	2022	We validate the groundwater isoscape against an independent data set of tap water values and show that the model accurately predicts tap water values in communities known to use groundwater resources.	Water	137-142	nuclear RNA export factor 1	Homo sapiens	133-136
35100166-8	2022	Our survey results suggest that orderly cleanliness encourages the choice of tap water filtered through water purifier, while aversive cleanliness urges the choice of bottled water.	Water	81-86	nuclear RNA export factor 1	Homo sapiens	77-80
35130549-1	2022	The relationships between the reversed-phase thin layer chromatographic retention parameters obtained on octadecyl-modified silica (RP-18) sorbent for mobile phases containing water and one of six water-miscible organic modifiers (acetone, methanol, acetonitrile, tetrahydrofurane, N,N-dimethylformamide, 1,4-dioxane) and skin permeability coefficients were studied for a group of 21 cosmetic raw materials, mainly organic sunscreens and preservatives.	Water	176-181	pre-mRNA processing factor 3	Homo sapiens	132-137
35242649-10	2022	Inhibiting delayed HIF-1alpha expression post-HI injury could restrain reactive gliosis, ameliorate hypomyelination, and improve the performance of rats in the Morris water maze test.	Water	167-172	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	19-29
35637265-7	2022	Our results in Cln1R151X mice suggest that acidified drinking water may have beneficial effects for patients with infantile Batten disease.	Water	62-67	palmitoyl-protein thioesterase 1	Mus musculus	15-19